term overlap setsize score pval edge type subtype subtype_key edge_idxs ann_idxs ann_vals sig_size Endoplasmic reticulum lumen 43 69 5.003637269468354 5.625857192924234e-07 Q8IXB1,P30533,P05067,Q9NWM8,P30040,Q32P28,O43852,Q8NBS9,Q14257,Q96HE7,Q7Z4H8,Q9Y4L1,Q13217,Q9Y680,P07237,Q15084,Q8NBJ7,P13674,Q969H8,Q9NYU2,Q9BTV4,P14625,P13667,P14314,P07942,O15460,Q02818,Q15293,Q96AY3,Q5JRA6,Q9BTY2,Q13438,P30101,P78536,Q07065,O75718,Q6P179,Q14554,O95881,P27824,Q9BS26,Q9NWW5,Q9NZ08 Localization GO Cellular component msigdb_gocc 129,132,385,8,386,12,16,402,20,411,283,416,166,39,41,419,44,47,304,306,311,184,443,324,196,194,74,203,75,342,90,91,352,226,100,99,103,108,237,118,251,252,127 1289,3617,577,194,2908,1026,16,493,99,780,237,385,41,196,3410,1054,580,443,47,324,184,1089,2667,3376,539,118,2769,386,352,132,909,979,1525,226,74,642,100,166,91,20,108,445,419,203,12,342,103,283,1418,129,3018,919,44,402,746,304,75,411,251,311,90,633,8,252,306,127,660,416,39 0.08978035873173802,-2.0288519737109936,0.71968985939333,1.824865383027324,-0.6452882514774274,0.25237072765834473,4.095354306912875,0.850660633843561,2.423291779810149,0.4506749437853009,1.6093549777202447,1.1239123190922105,3.2870083892475765,1.824865383027324,-1.0436847151728275,0.23224335926748166,0.71968985939333,0.9794004819604001,3.163027731650402,1.3008013122061457,1.8900097097013104,0.21206060116262693,-0.5323126699925248,-0.9956073764657654,0.776099228012361,2.285531889164803,-0.5772854996002308,1.1239123190922105,1.2128654372087189,2.192370287416088,0.3521891223123161,0.29246072303462184,-0.03458833609287247,1.64289728589414,2.633054429019238,0.6438120248840904,2.423291779810149,1.9706953778300438,2.483776090582276,3.8042718536546554,2.377631431346862,0.9794004819604001,1.0339137070490352,1.792091065872174,4.206660830311199,1.2481603149029503,2.3928800946790516,1.4566081122737937,0.027862332156932304,2.223543950079106,-0.6909922588809689,0.3521891223123161,3.204557850940264,1.0880399570282553,0.5091440599781275,1.3877470096535027,2.633054429019238,1.0700404706148139,1.592529825004484,1.3356969350852728,2.4988272513624805,0.6628536231131278,4.352908051790398,1.592529825004484,1.3877470096535027,2.239085653646518,0.6247218507870246,1.0519984666463416,3.314313786509081 3643 Intrinsic component of endoplasmic reticulum membrane 36 60 4.419819684740882 9.878329044532563e-06 Q9UM00,P30511,P51572,Q6Y1H2,Q8N4V1,Q86XL3,Q8TB61,Q86YN1,P27797,Q9HCU5,Q9Y282,Q9UKV5,O75298,P10321,Q92643,Q96A33,Q9Y4P3,Q969N2,O15533,Q9P035,Q5H8A4,Q99442,O95470,O75844,Q8N766,P30101,Q8TCT9,Q9NQC3,P61619,Q96S52,Q15629,Q12981,P27824,Q9BUN8,O43292,Q9NPA0 Localization GO Cellular component msigdb_gocc 259,6,397,529,274,18,410,155,539,415,162,169,546,48,187,188,193,586,329,340,207,467,209,217,349,352,364,365,363,234,112,367,118,122,373,391 1318,875,329,373,2357,546,217,780,3390,209,1139,579,48,539,118,352,6,397,625,363,829,367,2567,1332,915,112,207,833,1193,529,1418,18,155,274,349,410,1762,364,187,586,729,188,234,467,2018,122,415,391,365,1315,798,340,2077,1718,1280,169,259,162,193,2472 0.06919953703395551,0.37199154172998977,1.2832942009953483,1.1417856605713883,-0.42111741427401633,0.7573430676997512,1.659614804060893,0.4506749437853009,-1.019604048841438,1.7095549611048153,0.17152746597699287,0.71968985939333,3.135226461008061,0.776099228012361,2.285531889164803,1.2128654372087189,4.673387267370069,1.105997161876891,0.6628536231131278,1.1774078138827289,0.4114378359281686,1.1596174162013977,-0.48762464822389984,0.06919953703395551,0.3521891223123161,2.3470478270665613,1.742673161727919,0.4114378359281686,0.15117635458958095,0.7948087934495096,0.027862332156932304,3.906629108755367,2.050571853401436,1.473728476771492,1.2305331089305223,1.0700404706148139,-0.16113177748554827,1.1774078138827289,1.8575044941143102,0.71968985939333,0.5285319592869173,1.8575044941143102,1.6261440706577892,0.9244936801618757,-0.2683121372291175,2.254597454452404,1.0519984666463416,1.1239123190922105,1.1774078138827289,0.08978035873173802,0.4506749437853009,1.2657472734377568,-0.28994201948861137,-0.13988634815318823,0.11030317972784781,1.9706953778300438,1.5587706046077934,2.0027419959879986,1.8412017569470738,-0.44321720897869366 3643 Endoplasmic reticulum protein containing complex 38 68 4.282384589416514 1.849010401011597e-05 Q8IXB1,P67812,P04843,P04844,Q9UBV2,Q15005,P51571,Q8N4V1,P46977,P27797,Q9Y4L1,Q9UKV5,Q15084,P07237,P13674,P14625,Q92643,Q14697,P14314,Q969N2,O15533,Q8TCJ2,P04439,Q9UBU6,Q13438,Q9UGP8,Q8N766,Q9Y5M8,P30101,Q9H0U3,Q93063,Q8TCT9,Q14165,P61619,Q96S52,Q9BUN8,O43292,Q9NPA0 Localization GO Cellular component msigdb_gocc 129,128,384,395,143,269,400,274,152,539,416,169,419,41,47,184,187,445,324,586,329,336,579,82,91,221,349,98,352,491,359,364,486,363,234,122,373,391 1083,611,1879,329,2950,373,2357,1026,579,384,395,41,47,324,184,2667,539,352,1030,152,2264,400,2552,2611,2772,1407,363,3544,1362,128,829,1224,91,486,445,269,1332,915,419,762,833,1193,1066,129,274,349,3505,336,364,187,1817,359,586,1903,234,122,491,391,2077,660,82,143,221,169,3304,416,98,2472 0.21206060116262693,0.6818469365208409,-0.2252475557449799,1.2832942009953483,-0.6681029929832263,1.1417856605713883,-0.42111741427401633,0.25237072765834473,0.71968985939333,1.1239123190922105,1.105997161876891,3.2870083892475765,3.163027731650402,1.3008013122061457,1.8900097097013104,-0.5323126699925248,0.776099228012361,1.2128654372087189,0.25237072765834473,2.06645172244257,-0.37712313988404206,1.0880399570282553,-0.48762464822389984,-0.5099333245444402,-0.5772854996002308,0.027862332156932304,1.1774078138827289,-1.2892692909305767,0.04856032582182117,2.223543950079106,0.4114378359281686,0.13076838476814698,2.483776090582276,0.8691865207095048,0.9794004819604001,1.4908112708908634,0.06919953703395551,0.3521891223123161,1.0339137070490352,0.4897054676751104,0.4114378359281686,0.15117635458958095,0.23224335926748166,2.223543950079106,1.473728476771492,1.2305331089305223,-1.1899723271023945,1.2657472734377568,1.1774078138827289,1.8575044941143102,-0.18244015934691968,1.1951570795527422,0.71968985939333,-0.2252475557449799,1.6261440706577892,2.254597454452404,0.8691865207095048,1.1239123190922105,-0.28994201948861137,0.6247218507870246,2.5587558625495044,2.1296580535061174,1.659614804060893,1.9706953778300438,-0.900446979133231,1.0519984666463416,2.438455053388052,-0.44321720897869366 3643 Inner mitochondrial membrane protein complex 48 90 4.106641078426742 4.01454303633475e-05 Q13505,O60830,Q99595,P56378,O75438,P13073,O14949,Q9NWR8,P20674,O75380,Q9NX63,P21912,P14406,Q5XKP0,P03886,O75306,Q96CU9,O96000,Q8IYU8,Q99623,O95139,P47985,Q9Y5J7,O43676,Q9Y512,Q9Y584,Q9Y6M9,Q3ZCQ8,Q16891,P22695,O75489,Q9UDW1,O43674,Q9H4I9,O95168,P00403,O95167,O14548,P06576,Q9Y4W6,Q9Y5J6,P24539,O75964,O00217,O75251,P56556,Q86Y39,O14925 Localization GO Cellular component msigdb_gocc 519,0,2,518,768,515,137,659,651,650,544,538,28,670,277,535,413,664,786,167,548,808,433,50,575,308,183,566,700,563,696,198,321,78,470,87,341,717,92,620,751,362,110,734,366,624,497,754 734,1875,717,754,137,321,50,2358,0,366,535,650,1695,768,696,1138,110,548,341,470,806,1515,2155,664,1885,87,1000,277,953,92,1357,1583,1252,904,515,28,1056,1218,1932,3080,651,538,563,362,1517,2605,1405,881,2425,1141,2720,808,3463,3129,1258,518,931,624,519,1498,2280,700,566,1896,670,1010,497,786,1159,413,1863,2,167,1906,1966,78,1046,1278,659,2405,544,1349,198,1436,620,575,308,751,433,183 0.5091440599781275,-0.2252475557449799,0.5285319592869173,0.4897054676751104,2.1453820763492155,1.3008013122061457,3.107332731050088,-0.42111741427401633,5.89350676912575,1.1596174162013977,0.776099228012361,0.6247218507870246,-0.13988634815318823,0.4702158680735321,0.5671569209643074,0.17152746597699287,2.3623540515125967,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.6055828069993638,-0.2252475557449799,2.5138506890054337,0.2724430641772754,1.4566081122737937,0.31242405485919195,2.4535901140386045,0.04856032582182117,-0.0765234222627171,0.11030317972784781,0.3521891223123161,0.8134720365945656,3.5429255537908872,0.23224335926748166,0.13076838476814698,-0.24674747021415624,-0.7369966820229626,0.6247218507870246,0.776099228012361,0.7385400373905193,1.1774078138827289,-0.03458833609287247,-0.5099333245444402,0.027862332156932304,0.37199154172998977,-0.44321720897869366,0.17152746597699287,-0.5547632158192415,0.4310823742970927,-1.1164377040450824,-0.7601130162085916,0.11030317972784781,0.8134720365945656,0.33233340674752826,0.6628536231131278,0.8134720365945656,-0.013711595274741894,-0.37712313988404206,0.5671569209643074,0.7385400373905193,-0.2252475557449799,0.6055828069993638,0.2724430641772754,0.850660633843561,0.4506749437853009,0.17152746597699287,1.0519984666463416,-0.2038119362780547,5.347123193165582,1.9706953778300438,-0.2252475557449799,-0.24674747021415624,2.6034158117050517,0.25237072765834473,0.11030317972784781,0.6247218507870246,-0.42111741427401633,0.776099228012361,0.06919953703395551,1.824865383027324,0.027862332156932304,0.6818469365208409,0.7385400373905193,1.3704358233118867,0.5091440599781275,1.0157859516403132,1.9062125107768622 3643 Predicted secreted proteins 30 64 4.100065098918423 4.130339370123082e-05 P05067,Q8WUJ1,Q9UMX5,P22466,P14174,O94919,Q9H6E4,P80303,Q969H8,Q8NDZ4,Q9UM22,Q8NCW5,Q9Y4P3,P07942,Q02818,P02654,Q9HB40,P61916,Q9BTY2,P84157,O60888,O75718,Q6P179,P04083,Q8N128,Q08380,Q8NBM8,Q15165,Q9NZ08,Q6P1S2 Functions Protein Atlas Protein class protein_atlas_protein_class 385,10,21,406,150,31,168,43,304,438,51,317,193,196,74,202,464,466,90,94,222,99,103,484,369,245,248,121,127,124 1289,1691,493,222,99,1486,31,202,3606,484,385,2810,770,196,2093,1054,580,150,1401,1112,406,2667,1029,3224,1060,1557,3286,1525,466,2432,43,3288,94,74,653,245,1806,2561,2565,121,103,124,861,369,248,317,438,10,1071,1425,630,304,922,90,1966,1967,3614,168,843,464,127,51,21,193 0.08978035873173802,-0.13988634815318823,0.850660633843561,1.64289728589414,2.423291779810149,-0.013711595274741894,3.476322734521235,1.792091065872174,-1.8360748989715658,0.8691865207095048,1.1239123190922105,-0.5998800653389513,0.4702158680735321,1.824865383027324,-0.3116375849262432,0.23224335926748166,0.71968985939333,2.06645172244257,0.027862332156932304,0.1918220918189678,1.0700404706148139,-0.5323126699925248,0.25237072765834473,-0.829925724951396,0.23224335926748166,-0.055525473592154824,-0.900446979133231,-0.03458833609287247,0.9244936801618757,-0.44321720897869366,3.2321311079528603,-0.900446979133231,2.4535901140386045,2.633054429019238,0.6247218507870246,1.592529825004484,-0.18244015934691968,-0.48762464822389984,-0.48762464822389984,2.254597454452404,2.3928800946790516,2.239085653646518,0.3917410017874763,1.1596174162013977,1.592529825004484,1.318268819891666,0.99761495810321,4.231204838358074,0.23224335926748166,0.027862332156932304,0.6628536231131278,1.3877470096535027,0.3521891223123161,2.4988272513624805,-0.24674747021415624,-0.24674747021415624,-1.9455372097525145,1.9706953778300438,0.4114378359281686,0.9428400929877672,2.239085653646518,3.037189084386894,3.791391520603715,1.8412017569470738 3643 Protein localization 31 83 3.975941714890328 7.010129458917547e-05 Q13505,O60830,Q99595,Q9Y5J9,Q15067,P05067,Q9BTZ2,P50402,Q9UKG9,Q9NX63,P21796,P51648,Q5JRX3,Q9NR77,Q9Y3D6,O15254,P09601,Q9Y5J7,Q9Y512,Q9Y584,Q2T9J0,Q8N4H5,Q3ZCQ8,Q9NS69,Q7L5D6,Q15388,O75874,Q9BY49,O15228,P06576,P39210 Processes and pathways Reactome Pathways msigdb_reactome 519,0,2,392,387,385,139,396,403,544,278,32,35,42,173,302,175,433,575,308,309,56,566,63,585,201,457,81,465,92,505 1319,1438,754,465,302,825,1026,1484,779,0,1137,2714,1695,879,2539,1733,457,1106,806,697,385,92,1357,3591,175,2994,581,904,1401,278,2316,1517,759,1737,1448,2720,505,666,1631,396,1522,1144,32,957,2611,2772,1093,3051,1299,519,3378,387,201,309,566,35,585,1307,56,2012,2970,2,2585,139,81,1046,42,63,544,1785,2794,1434,403,1436,3029,173,575,308,751,433,392,1020,998 0.06919953703395551,0.007105158915106008,0.4897054676751104,0.9244936801618757,1.3877470096535027,0.4114378359281686,0.25237072765834473,-0.013711595274741894,0.4506749437853009,5.89350676912575,0.17152746597699287,-0.5547632158192415,-0.13988634815318823,0.37199154172998977,-0.48762464822389984,-0.16113177748554827,0.9428400929877672,0.1918220918189678,0.4310823742970927,0.5671569209643074,1.1239123190922105,2.4535901140386045,0.04856032582182117,-1.5962278705752115,1.9385192969684373,-0.6909922588809689,0.71968985939333,0.3521891223123161,0.027862332156932304,1.4566081122737937,-0.39908622494449625,-0.03458833609287247,0.4897054676751104,-0.16113177748554827,0.007105158915106008,-0.5547632158192415,0.832089227524965,0.6055828069993638,-0.09758260109774661,1.105997161876891,-0.03458833609287247,0.17152746597699287,3.476322734521235,0.31242405485919195,-0.5099333245444402,-0.5772854996002308,0.21206060116262693,-0.7139566269396745,0.08978035873173802,0.8134720365945656,-0.9956073764657654,1.1239123190922105,1.8084952079083476,1.3530858670526362,0.7385400373905193,3.4495350664729076,0.71968985939333,0.08978035873173802,2.9664513233824246,-0.2683121372291175,-0.6681029929832263,5.347123193165582,-0.48762464822389984,2.1453820763492155,2.5587558625495044,0.25237072765834473,3.2733225075135053,2.837587540785622,0.776099228012361,-0.16113177748554827,-0.5772854996002308,0.027862332156932304,1.0880399570282553,0.027862332156932304,-0.6909922588809689,1.9546235974626718,0.7385400373905193,1.3704358233118867,0.5091440599781275,1.0157859516403132,1.1239123190922105,0.2724430641772754,0.29246072303462184 3643 Thioredoxin domain [IPR013766] 18 27 3.8909922455634383 9.983512384925676e-05 Q8IXB1,Q9Y2G8,P30101,Q15084,O43396,P07237,Q9H3N1,Q13162,Q14554,Q9BS26,O95881,Q8NBS9,Q9H1E5,O43819,P13667,Q8NBF2,Q96JJ7,Q96J42 Sequence InterPro Domain interpro_domain 129,354,352,419,383,41,297,72,108,251,237,402,181,333,443,316,350,319 1876,383,333,3485,237,41,443,2547,2915,1058,352,1799,72,108,419,1231,989,129,316,402,319,350,251,181,297,354,448 -0.2252475557449799,1.1239123190922105,1.2657472734377568,-1.1653727114302805,1.6093549777202447,3.2870083892475765,0.9794004819604001,-0.48762464822389984,-0.6452882514774274,0.23224335926748166,1.2128654372087189,-0.18244015934691968,2.692012537294508,2.377631431346862,1.0339137070490352,0.13076838476814698,0.29246072303462184,2.223543950079106,1.318268819891666,1.0880399570282553,1.318268819891666,1.2305331089305223,1.592529825004484,1.9062125107768622,1.4050196301598754,1.2128654372087189,0.9794004819604001 3643 Glycoprotein metabolic process 37 78 3.8769451633867065 0.0001057761862812 O60512,Q8NCH0,P04843,P04844,Q92542,Q9H4A6,Q9H488,P46977,Q7Z4H8,Q86YN1,Q9BT22,Q9UKV5,Q8NAT1,O60476,Q9NYU2,Q9Y2G5,Q8N4A0,O60858,Q14697,P14314,Q9NQX7,O15294,Q8TCJ2,Q10472,Q9P2E5,Q6ZXV5,Q13724,Q9H0U3,Q02809,Q93063,Q14165,Q9BV10,Q9BXS4,Q96L58,O60568,Q96AA3,Q9BS26 Processes and pathways GO Biological process msigdb_gobp 253,133,384,395,531,276,674,152,283,155,161,169,46,545,306,53,180,60,445,324,592,328,336,210,608,214,356,491,613,359,486,633,371,631,493,250,251 822,2415,1438,2416,328,662,545,2909,253,493,2985,2801,60,2602,848,2805,902,384,395,324,1551,1057,1736,1627,783,1030,152,3544,1455,2864,613,2223,1189,1750,210,356,486,445,1951,214,1813,283,765,155,180,46,133,336,1375,531,359,250,1649,1042,631,3567,1165,251,161,633,371,491,1610,674,276,843,942,592,797,2143,306,608,1921,169,3518,53,2080,973 0.4114378359281686,-0.44321720897869366,0.007105158915106008,-0.44321720897869366,1.2832942009953483,0.6055828069993638,0.7573430676997512,-0.6452882514774274,1.5756684289722063,0.850660633843561,-0.6909922588809689,-0.5998800653389513,2.866397368803325,-0.5099333245444402,0.3917410017874763,-0.5998800653389513,0.3521891223123161,1.1239123190922105,1.105997161876891,1.3008013122061457,-0.055525473592154824,0.23224335926748166,-0.16113177748554827,-0.09758260109774661,0.4506749437853009,0.25237072765834473,2.06645172244257,-1.2892692909305767,0.007105158915106008,-0.6225474635721432,0.6818469365208409,-0.3552276637336356,0.15117635458958095,-0.16113177748554827,1.7095549611048153,1.1951570795527422,0.8691865207095048,0.9794004819604001,-0.24674747021415624,1.692943464578411,-0.18244015934691968,1.4566081122737937,0.4897054676751104,2.050571853401436,1.9062125107768622,3.190737263872994,2.1767380522239064,1.2657472734377568,0.04856032582182117,0.7948087934495096,1.1951570795527422,1.592529825004484,-0.09758260109774661,0.25237072765834473,0.6628536231131278,-1.390041774081608,0.17152746597699287,1.592529825004484,2.018717139797755,0.6628536231131278,1.1596174162013977,0.8691865207095048,-0.0765234222627171,0.6055828069993638,1.473728476771492,0.4114378359281686,0.33233340674752826,0.71968985939333,0.4506749437853009,-0.3116375849262432,1.3877470096535027,0.7007922534137548,-0.2252475557449799,1.9706953778300438,-1.2146610216914933,3.0230894408053492,-0.28994201948861137,0.31242405485919195 3643 Endoplasmic reticulum golgi intermediate compartment 23 60 3.7969739278331542 0.0001464731879998 P30533,P51572,Q9Y3A6,Q8N511,Q5BJH7,Q8NI22,P24390,Q9Y282,P07237,P80303,Q969H8,Q9NYU2,O15260,O95070,O15533,Q02818,Q96RQ1,Q96GC9,Q9BVK6,Q10472,P49755,P49257,Q9BS26 Localization GO Cellular component msigdb_gocc 132,397,268,13,146,22,151,162,41,43,304,306,52,67,329,74,76,208,212,210,225,238,251 512,803,52,2537,329,1179,67,41,2093,151,1057,539,132,1736,238,225,909,397,3003,979,1673,2728,43,74,829,1189,210,982,1299,3610,419,3169,815,643,146,3098,1011,787,13,22,1376,1765,304,729,208,3367,76,251,212,2398,1610,2022,306,3028,1921,162,268,1789,2471,2082 0.8134720365945656,0.4310823742970927,3.0230894408053492,-0.48762464822389984,1.2832942009953483,0.15117635458958095,2.794183911350097,3.2870083892475765,-0.3116375849262432,2.06645172244257,0.23224335926748166,0.776099228012361,2.192370287416088,-0.16113177748554827,1.6093549777202447,1.64289728589414,0.3521891223123161,1.105997161876891,-0.6909922588809689,0.29246072303462184,-0.11870343366061006,-0.5547632158192415,3.2321311079528603,2.633054429019238,0.4114378359281686,0.15117635458958095,1.7095549611048153,0.29246072303462184,0.08978035873173802,-1.8632698976234066,1.0339137070490352,-0.7833062289105431,0.4310823742970927,0.6438120248840904,2.0981172248521958,-0.7369966820229626,0.2724430641772754,0.4506749437853009,4.206660830311199,3.7655729970606435,0.04856032582182117,-0.16113177748554827,1.3877470096535027,0.5285319592869173,1.7261314689431049,-0.9716940090710073,2.6182485118089542,1.592529825004484,1.7095549611048153,-0.42111741427401633,-0.0765234222627171,-0.2683121372291175,1.3877470096535027,-0.6909922588809689,-0.2252475557449799,2.0027419959879986,1.5078566888617457,-0.16113177748554827,-0.44321720897869366,-0.28994201948861137 3643 Mitochondrial respiratory chain complex assembly 33 51 3.738642509007579 0.0001850166029713 Q7L592,O75438,Q69YU5,Q9H061,Q8N8Q8,Q96CU9,P03886,O75306,O96000,Q9NW81,O95139,P47985,O95169,O43676,Q9Y512,Q9Y6M9,O75489,Q9BSK2,O95831,O43674,Q15070,Q6DKK2,O43819,O95168,Q9Y2R0,O95167,O75880,Q8N183,O75251,O00217,P56556,Q86Y39,P0DJ07 Processes and pathways GO Biological process msigdb_gobp 774,768,145,148,285,413,277,535,664,691,548,808,806,50,575,183,696,327,195,321,200,332,333,470,86,341,718,602,366,734,624,497,756 734,321,50,2358,333,366,535,768,696,718,548,341,470,806,2155,195,664,277,953,756,2605,808,624,1188,200,1498,2280,145,332,774,497,865,602,285,1309,413,1683,1427,327,2235,148,993,1245,691,2405,1508,1349,1436,86,575,183 0.5091440599781275,1.3008013122061457,3.107332731050088,-0.42111741427401633,1.2657472734377568,1.1596174162013977,0.776099228012361,0.4702158680735321,0.5671569209643074,0.5285319592869173,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.333399306791712,1.824865383027324,0.6055828069993638,1.4566081122737937,0.31242405485919195,0.4897054676751104,-0.5099333245444402,0.4310823742970927,0.6628536231131278,0.15117635458958095,1.8084952079083476,-0.013711595274741894,-0.37712313988404206,2.113903150898959,1.2832942009953483,0.4702158680735321,0.850660633843561,0.3917410017874763,0.7007922534137548,1.4566081122737937,0.08978035873173802,1.0519984666463416,-0.11870343366061006,0.027862332156932304,1.3008013122061457,-0.3552276637336356,2.0981172248521958,0.29246072303462184,0.13076838476814698,0.5863945968863824,-0.42111741427401633,-0.013711595274741894,0.06919953703395551,0.027862332156932304,2.5288465238651407,0.7385400373905193,1.9062125107768622 3643 Primary active transmembrane transporter activity 35 67 3.659057541271288 0.0002531445013373 O75027,Q9HD20,P13073,O75438,P16615,P20674,O75380,P03886,O75306,O96000,O14678,O95139,P08183,P47985,O95169,O43676,Q9NUT2,Q9Y6M9,Q9NP58,P51797,O75489,Q9UDW1,O43674,O15533,Q15388,O95168,P00403,O95167,O14548,P06576,O75251,O00217,P56556,Q7KZN9,P28288 Functions GO Molecular function msigdb_gomf 260,136,515,768,267,651,650,277,535,664,301,548,303,808,806,50,431,183,447,191,696,198,321,329,201,470,87,341,717,92,366,734,624,378,759 734,1875,717,301,1176,329,321,50,2358,260,366,535,650,768,696,548,341,470,806,1515,2155,664,1885,87,277,953,976,1108,92,303,1357,1252,515,267,3080,1553,651,2855,3310,1624,759,2605,881,2318,1059,1588,808,3129,191,2219,624,1222,1117,829,201,1498,2280,378,136,447,2074,431,1349,198,1870,1512,183 0.5091440599781275,-0.2252475557449799,0.5285319592869173,1.3877470096535027,0.15117635458958095,1.2832942009953483,1.3008013122061457,3.107332731050088,-0.42111741427401633,1.5418361654019872,1.1596174162013977,0.776099228012361,0.6247218507870246,0.4702158680735321,0.5671569209643074,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.6055828069993638,-0.2252475557449799,2.5138506890054337,1.4566081122737937,0.31242405485919195,0.29246072303462184,0.1918220918189678,2.4535901140386045,1.3877470096535027,0.04856032582182117,0.11030317972784781,0.8134720365945656,1.5078566888617457,-0.7369966820229626,-0.055525473592154824,0.6247218507870246,-0.6225474635721432,-0.9241144775154201,-0.09758260109774661,0.4897054676751104,-0.5099333245444402,0.37199154172998977,-0.39908622494449625,0.23224335926748166,-0.0765234222627171,0.4310823742970927,-0.7601130162085916,1.8412017569470738,-0.3552276637336356,0.6628536231131278,0.13076838476814698,0.1918220918189678,0.4114378359281686,1.8084952079083476,-0.013711595274741894,-0.37712313988404206,1.1417856605713883,2.1610753620574217,0.9794004819604001,-0.28994201948861137,1.0157859516403132,0.06919953703395551,1.824865383027324,-0.2038119362780547,-0.013711595274741894,1.9062125107768622 3643 Active transmembrane transporter activity 45 90 3.624913688060172 0.0002890579742305 O75027,Q9HD20,P13073,O75438,P16615,Q9UBX3,P20674,O75380,P53985,P03886,O75306,O96000,O95139,O14678,P08183,P47985,O95169,O43676,P55011,Q9NUT2,Q9Y6M9,Q9Y6M7,P51797,O75489,Q9NP58,Q9UDW1,O43674,P04920,Q15388,O15533,P12235,Q02978,P41440,O95168,P00403,O95167,O14548,P06576,O75251,O00217,P56556,Q7KZN9,P28288,Q01650,O00400 Functions GO Molecular function msigdb_gomf 260,136,515,768,267,144,651,650,409,277,535,664,548,301,303,808,806,50,678,431,183,846,191,696,447,198,321,450,201,329,581,79,213,470,87,341,717,92,366,734,624,378,759,376,123 734,123,1875,717,301,1176,329,321,50,2358,260,366,535,650,768,696,548,341,470,806,1515,1028,2155,664,1885,87,277,953,450,976,1108,1581,92,303,1400,1357,1252,581,904,515,267,3080,1553,651,2855,3310,1624,759,2605,881,2318,1059,1588,213,808,3129,1942,191,2219,1491,409,678,624,1222,1117,2222,376,79,829,1893,201,1301,1498,2280,378,1159,3514,3566,136,447,2074,431,1349,144,198,1870,1512,1287,846,183 0.5091440599781275,2.239085653646518,-0.2252475557449799,0.5285319592869173,1.3877470096535027,0.15117635458958095,1.2832942009953483,1.3008013122061457,3.107332731050088,-0.42111741427401633,1.5418361654019872,1.1596174162013977,0.776099228012361,0.6247218507870246,0.4702158680735321,0.5671569209643074,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,0.25237072765834473,-0.333399306791712,0.6055828069993638,-0.2252475557449799,2.5138506890054337,1.4566081122737937,0.31242405485919195,0.9611422765478006,0.29246072303462184,0.1918220918189678,-0.0765234222627171,2.4535901140386045,1.3877470096535027,0.027862332156932304,0.04856032582182117,0.11030317972784781,0.71968985939333,0.3521891223123161,0.8134720365945656,1.5078566888617457,-0.7369966820229626,-0.055525473592154824,0.6247218507870246,-0.6225474635721432,-0.9241144775154201,-0.09758260109774661,0.4897054676751104,-0.5099333245444402,0.37199154172998977,-0.39908622494449625,0.23224335926748166,-0.0765234222627171,1.692943464578411,0.4310823742970927,-0.7601130162085916,-0.24674747021415624,1.8412017569470738,-0.3552276637336356,-0.013711595274741894,1.0700404706148139,0.5863945968863824,0.6628536231131278,0.13076838476814698,0.1918220918189678,-0.3552276637336356,1.1417856605713883,2.5885562139486704,0.4114378359281686,-0.2252475557449799,1.8084952079083476,0.08978035873173802,-0.013711595274741894,-0.37712313988404206,1.1417856605713883,0.17152746597699287,-1.2146610216914933,-1.390041774081608,2.1610753620574217,0.9794004819604001,-0.28994201948861137,1.0157859516403132,0.06919953703395551,2.1296580535061174,1.824865383027324,-0.2038119362780547,-0.013711595274741894,0.11030317972784781,0.4114378359281686,1.9062125107768622 3643 Endoplasmic reticulum golgi intermediate compartment membrane 15 34 3.6193933358754937 0.0002952944980283 Q9Y282,O95070,P49755,O15533,Q9Y3A6,Q8N511,Q96RQ1,P49257,Q96GC9,Q5BJH7,Q9BVK6,O15260,Q10472,Q8NI22,P24390 Localization GO Cellular component msigdb_gocc 162,67,225,329,268,13,76,238,208,146,212,52,210,22,151 512,52,2537,329,1179,67,151,1057,539,238,225,397,979,2728,829,1189,210,982,1299,3169,815,643,146,13,22,729,208,76,212,2398,1610,162,268,1789 0.8134720365945656,3.0230894408053492,-0.48762464822389984,1.2832942009953483,0.15117635458958095,2.794183911350097,2.06645172244257,0.23224335926748166,0.776099228012361,1.6093549777202447,1.64289728589414,1.105997161876891,0.29246072303462184,-0.5547632158192415,0.4114378359281686,0.15117635458958095,1.7095549611048153,0.29246072303462184,0.08978035873173802,-0.7833062289105431,0.4310823742970927,0.6438120248840904,2.0981172248521958,4.206660830311199,3.7655729970606435,0.5285319592869173,1.7261314689431049,2.6182485118089542,1.7095549611048153,-0.42111741427401633,-0.0765234222627171,2.0027419959879986,1.5078566888617457,-0.16113177748554827 3643 Membrane lipid metabolic process 28 44 3.619056885531929 0.000295678642747 O60512,P27544,P17900,Q6Y1H2,Q16739,Q8NBX0,P04066,P06280,Q96G23,Q92643,P04062,Q969N2,Q9P035,Q9H2C2,Q5H8A4,O95470,Q06136,Q99735,Q9NZJ7,P07602,Q8NCC3,Q96S52,O15269,P50897,Q16880,Q9NWW5,O43292,Q9NRA0 Processes and pathways GO Biological process msigdb_gobp 253,5,516,529,282,33,426,549,55,187,449,586,340,337,207,209,347,618,492,231,358,234,611,244,246,252,373,257 611,1879,373,253,2801,209,449,426,549,1356,231,3508,1886,516,2488,5,2259,244,3049,347,3358,282,246,1896,207,529,33,358,187,586,55,234,618,1165,337,257,252,1130,798,3210,492,340,1785,649 0.6818469365208409,-0.2252475557449799,1.1417856605713883,1.5756684289722063,-0.5998800653389513,1.7095549611048153,0.9611422765478006,1.0157859516403132,0.7573430676997512,0.04856032582182117,1.6261440706577892,-1.2146610216914933,-0.2252475557449799,0.8134720365945656,-0.465386116003162,4.73149126850177,-0.37712313988404206,1.592529825004484,-0.7139566269396745,1.2305331089305223,-0.9716940090710073,1.4566081122737937,1.592529825004484,-0.2252475557449799,1.742673161727919,0.7948087934495096,3.476322734521235,1.1951570795527422,1.8575044941143102,0.71968985939333,2.980646976640566,1.6261440706577892,0.6818469365208409,0.17152746597699287,1.2657472734377568,1.5756684289722063,1.592529825004484,0.1918220918189678,0.4506749437853009,-0.8065769270037231,0.8691865207095048,1.2657472734377568,-0.16113177748554827,0.6438120248840904 3643 Glycoprotein biosynthetic process 32 68 3.5997069010157627 0.0003185760652848 O60512,Q8NCH0,P04843,P04844,Q92542,Q9H4A6,Q9H488,P46977,Q7Z4H8,Q86YN1,Q9BT22,Q8NAT1,O60476,Q9NYU2,Q9Y2G5,Q8N4A0,Q9NQX7,O15294,Q8TCJ2,Q10472,Q6ZXV5,Q9P2E5,Q13724,Q9H0U3,Q02809,Q93063,Q14165,Q9BV10,Q9BXS4,Q96L58,O60568,Q96AA3 Processes and pathways GO Biological process msigdb_gobp 253,133,384,395,531,276,674,152,283,155,161,46,545,306,53,180,592,328,336,210,214,608,356,491,613,359,486,633,371,631,493,250 822,1438,2416,328,662,545,2909,253,493,2985,2801,2602,848,2805,902,384,395,1551,1057,1736,1627,783,1030,152,3544,2864,613,2223,1189,1750,210,356,486,1951,214,1813,283,765,155,180,46,133,336,1375,531,359,250,1649,1042,631,1165,161,633,371,491,674,276,843,942,592,2143,306,608,1921,3518,53,2080,973 0.4114378359281686,0.007105158915106008,-0.44321720897869366,1.2832942009953483,0.6055828069993638,0.7573430676997512,-0.6452882514774274,1.5756684289722063,0.850660633843561,-0.6909922588809689,-0.5998800653389513,-0.5099333245444402,0.3917410017874763,-0.5998800653389513,0.3521891223123161,1.1239123190922105,1.105997161876891,-0.055525473592154824,0.23224335926748166,-0.16113177748554827,-0.09758260109774661,0.4506749437853009,0.25237072765834473,2.06645172244257,-1.2892692909305767,-0.6225474635721432,0.6818469365208409,-0.3552276637336356,0.15117635458958095,-0.16113177748554827,1.7095549611048153,1.1951570795527422,0.8691865207095048,-0.24674747021415624,1.692943464578411,-0.18244015934691968,1.4566081122737937,0.4897054676751104,2.050571853401436,1.9062125107768622,3.190737263872994,2.1767380522239064,1.2657472734377568,0.04856032582182117,0.7948087934495096,1.1951570795527422,1.592529825004484,-0.09758260109774661,0.25237072765834473,0.6628536231131278,0.17152746597699287,2.018717139797755,0.6628536231131278,1.1596174162013977,0.8691865207095048,0.6055828069993638,1.473728476771492,0.4114378359281686,0.33233340674752826,0.71968985939333,-0.3116375849262432,1.3877470096535027,0.7007922534137548,-0.2252475557449799,-1.2146610216914933,3.0230894408053492,-0.28994201948861137,0.31242405485919195 3643 Endopeptidase activity 28 70 3.594983290955096 0.0003244123972327 P67812,P49721,P60900,Q9BYT8,Q92542,O14773,Q96RU2,Q5JRX3,P28070,Q16740,P28072,Q2T9J0,Q92643,P22695,P52888,Q4J6C6,Q92905,O43847,O75844,P30101,P78536,Q6P179,Q8TCT9,P28074,Q9BXS4,Q9NZ08,Q99436,O43292 Functions GO Molecular function msigdb_gomf 128,131,262,141,531,25,288,35,170,428,54,309,187,563,325,459,77,578,217,352,226,103,364,243,371,127,381,373 25,2246,373,578,879,217,2989,2092,3159,2853,1401,3336,1219,563,3264,170,54,243,3474,352,1519,1628,955,2493,2263,2163,131,1803,325,979,3004,262,128,226,1093,913,3398,2441,428,309,459,35,723,1193,103,2448,1307,3017,1762,364,531,187,77,2970,1533,655,288,841,381,1466,866,1905,371,141,795,127,1248,1133,2412,620 3.661517338984293,-0.37712313988404206,1.1417856605713883,0.71968985939333,0.37199154172998977,1.659614804060893,-0.6909922588809689,-0.3116375849262432,-0.7833062289105431,-0.6225474635721432,0.027862332156932304,-0.947863266551478,0.13076838476814698,0.7385400373905193,-0.8768601169890071,1.9546235974626718,2.980646976640566,1.592529825004484,-1.1408614189622066,1.2128654372087189,-0.03458833609287247,-0.09758260109774661,0.31242405485919195,-0.465386116003162,-0.37712313988404206,-0.333399306791712,2.2079722071857653,-0.18244015934691968,1.3008013122061457,0.29246072303462184,-0.6909922588809689,1.5418361654019872,2.223543950079106,1.64289728589414,0.21206060116262693,0.3521891223123161,-1.019604048841438,-0.44321720897869366,1.0157859516403132,1.3530858670526362,0.9428400929877672,3.4495350664729076,0.5285319592869173,0.15117635458958095,2.3928800946790516,-0.44321720897869366,0.08978035873173802,-0.6909922588809689,-0.16113177748554827,1.1774078138827289,0.7948087934495096,1.8575044941143102,2.6034158117050517,-0.6681029929832263,-0.03458833609287247,0.6247218507870246,1.4394499815716364,0.4114378359281686,1.1417856605713883,0.007105158915106008,0.3917410017874763,-0.2252475557449799,1.1596174162013977,2.1296580535061174,0.4506749437853009,2.239085653646518,0.13076838476814698,0.1918220918189678,-0.42111741427401633,0.6818469365208409 3643 Intrinsic component of organelle membrane 84 149 3.5832584439573525 0.000339334566064 Q13505,O60830,Q99595,P30511,Q6Y1H2,Q86XL3,Q9NX63,P27797,O75298,P10321,Q9Y5Z9,Q9Y512,O95070,Q5T9L3,Q969N2,P12235,Q9H4I9,P04439,Q9Y2R0,Q9Y4W6,Q9HC21,Q15629,P27824,P57088,Q9BUN8,Q8IVP5,Q9NWR8,Q5BJH7,Q86YN1,Q5XKP0,Q9UG56,Q9Y282,O43505,Q9UH99,Q9UKV5,Q9Y3D6,Q92643,Q96A33,Q16891,O96008,Q9Y4P3,Q15070,Q15388,P50416,Q6P4A7,Q5H8A4,Q969X5,O95470,O75844,O75880,Q9GZY8,P57105,Q96S52,O60499,P0DJ07,O14925,Q9UM00,O94901,Q9NZ01,Q8N4V1,Q8N8Q8,Q14739,O76024,Q9BTV4,O15533,Q9P035,O43819,Q8N2H4,Q8N766,P30101,Q8TCT9,Q9NQC3,P61619,Q12981,Q5SNT2,O43292,Q9NPA0,P51572,Q8TB61,Q9HCU5,Q9NP58,Q9H3K2,Q99442,Q9BUB7 Localization GO Cellular component msigdb_gocc 519,0,2,6,529,18,544,539,546,48,576,575,67,69,586,581,78,579,86,620,619,112,118,625,122,645,659,146,155,670,159,162,662,164,169,173,187,188,700,697,193,200,201,709,725,207,729,209,217,718,220,232,234,242,756,754,259,769,798,274,285,281,780,311,329,340,333,348,349,352,364,365,363,367,377,373,391,397,410,415,447,468,467,490 1318,1395,875,754,2416,803,329,373,2357,662,1086,779,333,242,0,546,1695,217,718,780,3390,1106,769,67,999,209,1580,697,1139,579,756,48,581,3555,1553,3126,539,118,352,6,2720,955,1184,709,2722,397,625,232,1260,363,1117,2222,829,1750,367,519,2567,281,1332,915,200,1367,201,112,2625,3382,700,1896,146,207,833,377,69,670,1193,725,1010,529,989,863,1418,18,1565,155,645,1233,1760,1643,348,274,349,285,1461,1159,410,1762,364,1199,187,586,729,188,3633,2884,2583,234,467,2,1906,2018,311,490,122,1966,1469,220,468,78,1313,1101,619,415,447,391,365,2074,1278,659,544,1315,798,340,2077,1718,1280,159,2898,164,169,259,162,86,926,173,193,620,575,576,2472 0.06919953703395551,0.027862332156932304,0.37199154172998977,0.4897054676751104,-0.44321720897869366,0.4310823742970927,1.2832942009953483,1.1417856605713883,-0.42111741427401633,0.6055828069993638,0.21206060116262693,0.4506749437853009,1.2657472734377568,1.592529825004484,5.89350676912575,0.7573430676997512,-0.13988634815318823,1.659614804060893,0.5285319592869173,0.4506749437853009,-1.019604048841438,0.1918220918189678,0.4702158680735321,2.794183911350097,0.2724430641772754,1.7095549611048153,-0.0765234222627171,0.5671569209643074,0.17152746597699287,0.71968985939333,0.4897054676751104,3.135226461008061,0.71968985939333,-1.3394678563793248,-0.055525473592154824,-0.7601130162085916,0.776099228012361,2.285531889164803,1.2128654372087189,4.673387267370069,-0.5547632158192415,0.31242405485919195,0.15117635458958095,0.5478694768628188,-0.5547632158192415,1.105997161876891,0.6628536231131278,1.6261440706577892,0.11030317972784781,1.1774078138827289,0.1918220918189678,-0.3552276637336356,0.4114378359281686,-0.16113177748554827,1.1596174162013977,0.8134720365945656,-0.48762464822389984,1.4566081122737937,0.06919953703395551,0.3521891223123161,1.8084952079083476,0.04856032582182117,1.8084952079083476,2.3470478270665613,-0.5099333245444402,-0.9956073764657654,0.5671569209643074,-0.2252475557449799,2.0981172248521958,1.742673161727919,0.4114378359281686,1.1417856605713883,2.7651210132024806,0.6055828069993638,0.15117635458958095,0.5285319592869173,0.2724430641772754,0.7948087934495096,0.29246072303462184,0.3917410017874763,0.027862332156932304,3.906629108755367,-0.055525473592154824,2.050571853401436,0.6438120248840904,0.13076838476814698,-0.16113177748554827,-0.09758260109774661,1.2305331089305223,1.473728476771492,1.2305331089305223,1.4566081122737937,0.007105158915106008,0.17152746597699287,1.0700404706148139,-0.16113177748554827,1.1774078138827289,0.15117635458958095,1.8575044941143102,0.71968985939333,0.5285319592869173,1.8575044941143102,-3.0906760096205748,-0.6225474635721432,-0.48762464822389984,1.6261440706577892,0.9244936801618757,5.347123193165582,-0.2252475557449799,-0.2683121372291175,1.3356969350852728,0.8691865207095048,2.254597454452404,-0.24674747021415624,0.007105158915106008,1.659614804060893,0.9244936801618757,2.6034158117050517,0.08978035873173802,0.21206060116262693,0.6818469365208409,1.0519984666463416,0.9794004819604001,1.1239123190922105,1.1774078138827289,-0.28994201948861137,0.11030317972784781,0.6247218507870246,0.776099228012361,0.08978035873173802,0.4506749437853009,1.2657472734377568,-0.28994201948861137,-0.13988634815318823,0.11030317972784781,2.034660375542446,-0.6225474635721432,1.9867347928109564,1.9706953778300438,1.5587706046077934,2.0027419959879986,2.5288465238651407,0.3521891223123161,1.9546235974626718,1.8412017569470738,0.6818469365208409,0.7385400373905193,0.7385400373905193,-0.44321720897869366 3643 Membrane lipid biosynthetic process 18 28 3.5435514834619446 0.0003947762234464 O60512,Q8NBX0,P27544,P04062,Q969N2,Q96S52,O15269,Q9P035,Q5H8A4,Q6Y1H2,Q06136,O95470,Q16739,Q16880,Q96G23,Q92643,O43292,Q9NRA0 Processes and pathways GO Biological process msigdb_gobp 253,33,5,449,586,234,611,340,207,529,347,209,282,246,55,187,373,257 611,1879,373,253,2801,209,449,2488,5,3049,347,3358,282,246,1896,207,529,33,187,586,55,234,1165,257,1130,340,1785,649 0.6818469365208409,-0.2252475557449799,1.1417856605713883,1.5756684289722063,-0.5998800653389513,1.7095549611048153,0.9611422765478006,-0.465386116003162,4.73149126850177,-0.7139566269396745,1.2305331089305223,-0.9716940090710073,1.4566081122737937,1.592529825004484,-0.2252475557449799,1.742673161727919,0.7948087934495096,3.476322734521235,1.8575044941143102,0.71968985939333,2.980646976640566,1.6261440706577892,0.17152746597699287,1.5756684289722063,0.1918220918189678,1.2657472734377568,-0.16113177748554827,0.6438120248840904 3643 Respirasome 31 54 3.4965036696951186 0.000471398010051 O75438,P13073,O14949,P20674,O75380,P21912,P14406,Q96CU9,P03886,O75306,O96000,O95139,P47985,O43676,Q9Y6M9,P22695,O75489,Q9UDW1,O43674,Q9Y241,Q6DKK2,O95168,P00403,O95167,O14548,O75251,O00217,Q13423,P56556,Q7KZN9,Q86Y39 Localization GO Cellular component msigdb_gocc 768,515,137,651,650,538,28,413,277,535,664,548,808,50,183,563,696,198,321,593,332,470,87,341,717,366,734,114,624,378,497 734,1875,717,137,321,50,2358,366,535,650,768,696,548,341,470,806,1515,2155,664,1885,87,277,953,1357,1583,1252,515,28,1056,1218,3080,651,538,563,2605,1405,881,808,3129,624,114,1498,2280,332,378,497,413,2890,2405,1349,198,593,1436,183 0.5091440599781275,-0.2252475557449799,0.5285319592869173,2.1453820763492155,1.3008013122061457,3.107332731050088,-0.42111741427401633,1.1596174162013977,0.776099228012361,0.6247218507870246,0.4702158680735321,0.5671569209643074,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.6055828069993638,-0.2252475557449799,2.5138506890054337,1.4566081122737937,0.31242405485919195,0.04856032582182117,-0.0765234222627171,0.11030317972784781,0.8134720365945656,3.5429255537908872,0.23224335926748166,0.13076838476814698,-0.7369966820229626,0.6247218507870246,0.776099228012361,0.7385400373905193,-0.5099333245444402,0.027862332156932304,0.37199154172998977,0.4310823742970927,-0.7601130162085916,0.6628536231131278,2.331712628995581,-0.013711595274741894,-0.37712313988404206,1.2832942009953483,1.1417856605713883,0.850660633843561,1.0519984666463416,-0.6225474635721432,-0.42111741427401633,0.06919953703395551,1.824865383027324,0.71968985939333,0.027862332156932304,1.9062125107768622 3643 er 36 100 3.490579081855833 0.0004819749458573 Q96N66,Q9UM00,P04843,Q9BVG9,O96005,P51572,P04844,Q8N4V1,P46977,Q14739,Q969Q5,Q15392,Q99640,O15173,Q9Y6K0,Q9H6H4,Q6NUK4,Q9P2W9,Q96A33,Q9BRK0,Q8TCJ2,Q96GC9,O95470,Q06136,Q8N766,Q9Y5M8,Q07065,P49755,Q9NQC3,P48449,Q12981,O00264,O60499,P27824,Q9NPA0,O00400 Localization OpenCell Localization opencell_localization 389,259,384,390,9,397,395,274,152,281,287,160,289,37,296,312,186,58,188,189,336,208,209,347,349,98,100,225,365,107,367,236,242,118,391,123 236,123,875,3262,37,611,1879,2357,242,2602,1179,805,1883,2035,209,513,9,3373,1621,384,395,2210,3040,3354,3083,118,1030,152,107,3564,225,2105,3285,397,2552,2772,2496,2728,1453,3544,2433,1007,681,347,100,2378,367,1299,281,1332,915,3169,160,1152,1558,1095,1120,833,2060,186,3504,2967,1459,520,274,349,1461,557,837,3102,336,3468,1647,728,287,421,188,208,389,289,189,2018,390,1607,312,1825,391,365,995,1244,2077,1785,58,259,1689,1285,502,98,873,296 1.6093549777202447,2.239085653646518,0.37199154172998977,-0.8768601169890071,3.314313786509081,0.6818469365208409,-0.2252475557449799,-0.42111741427401633,1.592529825004484,-0.5099333245444402,0.15117635458958095,0.4310823742970927,-0.2252475557449799,-0.28994201948861137,1.7095549611048153,0.8134720365945656,4.243451171065863,-0.9956073764657654,-0.09758260109774661,1.1239123190922105,1.105997161876891,-0.3552276637336356,-0.7139566269396745,-0.9716940090710073,-0.7369966820229626,2.285531889164803,0.25237072765834473,2.06645172244257,2.377631431346862,-1.390041774081608,1.64289728589414,-0.3116375849262432,-0.900446979133231,1.105997161876891,-0.48762464822389984,-0.5772854996002308,-0.465386116003162,-0.5547632158192415,0.007105158915106008,-1.2892692909305767,-0.44321720897869366,0.2724430641772754,0.5863945968863824,1.2305331089305223,2.423291779810149,-0.42111741427401633,1.1596174162013977,0.08978035873173802,1.4566081122737937,0.06919953703395551,0.3521891223123161,-0.7833062289105431,2.018717139797755,0.17152746597699287,-0.055525473592154824,0.21206060116262693,0.1918220918189678,0.4114378359281686,-0.28994201948861137,1.8575044941143102,-1.1899723271023945,-0.6681029929832263,0.007105158915106008,0.8134720365945656,1.473728476771492,1.2305331089305223,0.007105158915106008,0.7573430676997512,0.4114378359281686,-0.7369966820229626,1.2657472734377568,-1.1164377040450824,-0.09758260109774661,0.5285319592869173,1.4394499815716364,1.0339137070490352,1.8575044941143102,1.7261314689431049,1.1239123190922105,1.4394499815716364,1.8575044941143102,-0.2683121372291175,1.1239123190922105,-0.0765234222627171,1.3356969350852728,-0.18244015934691968,1.1239123190922105,1.1774078138827289,0.29246072303462184,0.13076838476814698,-0.28994201948861137,-0.16113177748554827,2.9094252815894692,1.5587706046077934,-0.11870343366061006,0.11030317972784781,0.850660633843561,2.438455053388052,0.3917410017874763,1.4222538872246275 3643 Glycosylation 30 59 3.4743136604422955 0.0005121619555648 O60512,P04843,P04844,Q9H488,P46977,Q7Z4H8,Q86YN1,Q9BT22,Q8NAT1,O60476,Q9NYU2,Q9Y2V7,Q9Y2G5,Q8N4A0,P04062,O15294,Q8TCJ2,Q10472,Q6ZXV5,O75503,Q13724,Q9H0U3,Q02809,Q93063,Q14165,Q9BV10,Q9BXS4,Q96L58,O60568,Q96AA3 Processes and pathways GO Biological process msigdb_gobp 253,384,395,674,152,283,155,161,46,545,306,574,53,180,449,328,336,210,214,479,356,491,613,359,486,633,371,631,493,250 822,2416,328,662,545,2909,253,493,2801,2602,848,479,2805,902,449,384,395,1551,1057,1736,1030,152,3544,2864,613,2223,1189,1750,210,356,486,1951,214,283,765,155,180,46,336,359,250,1042,631,1770,161,633,371,491,674,843,942,1383,306,1921,2145,53,574,2080,973 0.4114378359281686,-0.44321720897869366,1.2832942009953483,0.6055828069993638,0.7573430676997512,-0.6452882514774274,1.5756684289722063,0.850660633843561,-0.5998800653389513,-0.5099333245444402,0.3917410017874763,0.8876671508686171,-0.5998800653389513,0.3521891223123161,0.9611422765478006,1.1239123190922105,1.105997161876891,-0.055525473592154824,0.23224335926748166,-0.16113177748554827,0.25237072765834473,2.06645172244257,-1.2892692909305767,-0.6225474635721432,0.6818469365208409,-0.3552276637336356,0.15117635458958095,-0.16113177748554827,1.7095549611048153,1.1951570795527422,0.8691865207095048,-0.24674747021415624,1.692943464578411,1.4566081122737937,0.4897054676751104,2.050571853401436,1.9062125107768622,3.190737263872994,1.2657472734377568,1.1951570795527422,1.592529825004484,0.25237072765834473,0.6628536231131278,-0.16113177748554827,2.018717139797755,0.6628536231131278,1.1596174162013977,0.8691865207095048,0.6055828069993638,0.4114378359281686,0.33233340674752826,0.04856032582182117,1.3877470096535027,-0.2252475557449799,-0.3116375849262432,3.0230894408053492,0.7385400373905193,-0.28994201948861137,0.31242405485919195 3643 Ire1alpha activates chaperones 10 26 3.469890055639832 0.0005206714472889 Q9Y4L1,Q9Y5M8,O95070,Q13217,Q9NWM8,Q14554,P43307,Q969H8,O14773,Q9HCU5 Processes and pathways Reactome Pathways msigdb_reactome 416,98,67,166,8,108,14,304,25,415 512,25,780,1696,67,826,2210,907,14,1183,2044,1557,1222,2223,166,1494,108,419,1198,304,415,8,660,3071,416,98 0.8134720365945656,3.661517338984293,0.4506749437853009,-0.13988634815318823,2.794183911350097,0.4114378359281686,-0.3552276637336356,0.3521891223123161,4.1449986542955966,0.15117635458958095,-0.28994201948861137,-0.055525473592154824,0.13076838476814698,-0.3552276637336356,1.9706953778300438,-0.013711595274741894,2.377631431346862,1.0339137070490352,0.15117635458958095,1.3877470096535027,1.0519984666463416,4.352908051790398,0.6247218507870246,-0.7139566269396745,1.0519984666463416,2.438455053388052 3643 Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 33 75 3.437080551735712 0.0005880206989172 Q7L592,O75438,P13073,O14949,P20674,O75380,Q8N8Q8,P21912,P03886,O75306,O96000,O95139,P47985,O43676,Q9Y6M9,P22695,O75489,Q9UDW1,O43674,O43819,O95168,P00403,O95167,O75880,O14548,P06576,Q8N183,P24539,O75964,O00217,O75251,P56556,Q86Y39 Processes and pathways Reactome Pathways msigdb_reactome 774,768,515,137,651,650,285,538,277,535,664,548,808,50,183,563,696,198,321,333,470,87,341,718,717,92,602,362,110,734,366,624,497 734,1875,717,137,321,50,2358,333,366,535,650,768,696,718,1138,110,548,341,470,806,1515,2155,664,1885,87,1000,277,953,92,1357,1583,1252,515,3334,1056,1218,1932,3080,651,538,563,362,1517,2605,1405,881,1141,2607,1521,808,3463,3129,1258,931,624,1146,2625,1498,2280,774,497,865,602,285,1309,1683,1535,2235,993,1017,2405,1508,1349,198,183 0.5091440599781275,-0.2252475557449799,0.5285319592869173,2.1453820763492155,1.3008013122061457,3.107332731050088,-0.42111741427401633,1.2657472734377568,1.1596174162013977,0.776099228012361,0.6247218507870246,0.4702158680735321,0.5671569209643074,0.5285319592869173,0.17152746597699287,2.3623540515125967,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.6055828069993638,-0.2252475557449799,2.5138506890054337,0.2724430641772754,1.4566081122737937,0.31242405485919195,2.4535901140386045,0.04856032582182117,-0.0765234222627171,0.11030317972784781,0.8134720365945656,-0.947863266551478,0.23224335926748166,0.13076838476814698,-0.24674747021415624,-0.7369966820229626,0.6247218507870246,0.776099228012361,0.7385400373905193,1.1774078138827289,-0.03458833609287247,-0.5099333245444402,0.027862332156932304,0.37199154172998977,0.17152746597699287,-0.5099333245444402,-0.03458833609287247,0.4310823742970927,-1.1164377040450824,-0.7601130162085916,0.11030317972784781,0.33233340674752826,0.6628536231131278,0.17152746597699287,-0.5099333245444402,-0.013711595274741894,-0.37712313988404206,0.4702158680735321,0.850660633843561,0.3917410017874763,0.7007922534137548,1.4566081122737937,0.08978035873173802,-0.11870343366061006,-0.03458833609287247,-0.3552276637336356,0.29246072303462184,0.2724430641772754,-0.42111741427401633,-0.013711595274741894,0.06919953703395551,1.824865383027324,1.9062125107768622 3643 Electron transport chain oxphos system in mitochondria 31 60 3.4267033512723 0.000610956114279 O75438,P13073,O14949,P20674,O75380,P21912,P14406,P03886,O75306,O96000,O95139,P47985,O43676,Q9Y6M9,P22695,O75489,Q9UDW1,O43674,P12235,O95168,P00403,O95167,O75880,O14548,P06576,P24539,O75964,O00217,O75251,P56556,Q7KZN9 Processes and pathways WikiPathways msigdb_wp 768,515,137,651,650,538,28,277,535,664,548,808,50,183,563,696,198,321,581,470,87,341,718,717,92,362,110,734,366,624,378 734,1875,717,137,321,50,2358,366,535,650,768,696,718,1138,110,548,341,470,806,1515,2155,664,1885,87,1000,277,953,1581,92,1583,1252,581,904,515,28,1056,1218,1932,3080,651,538,563,362,1517,2605,1405,881,1141,808,3463,3129,1258,931,624,1498,2280,378,198,1105,183 0.5091440599781275,-0.2252475557449799,0.5285319592869173,2.1453820763492155,1.3008013122061457,3.107332731050088,-0.42111741427401633,1.1596174162013977,0.776099228012361,0.6247218507870246,0.4702158680735321,0.5671569209643074,0.5285319592869173,0.17152746597699287,2.3623540515125967,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.6055828069993638,-0.2252475557449799,2.5138506890054337,0.2724430641772754,1.4566081122737937,0.31242405485919195,-0.0765234222627171,2.4535901140386045,-0.0765234222627171,0.11030317972784781,0.71968985939333,0.3521891223123161,0.8134720365945656,3.5429255537908872,0.23224335926748166,0.13076838476814698,-0.24674747021415624,-0.7369966820229626,0.6247218507870246,0.776099228012361,0.7385400373905193,1.1774078138827289,-0.03458833609287247,-0.5099333245444402,0.027862332156932304,0.37199154172998977,0.17152746597699287,0.4310823742970927,-1.1164377040450824,-0.7601130162085916,0.11030317972784781,0.33233340674752826,0.6628536231131278,-0.013711595274741894,-0.37712313988404206,1.1417856605713883,1.824865383027324,0.21206060116262693,1.9062125107768622 3643 Tetrapyrrole binding 14 23 3.4248767578782666 0.0006150783652592 Q6UW02,Q96EY8,O15173,Q9NPF0,Q8WUJ1,P53701,Q9NRV9,O43169,P09601,O00264,Q7KZN9,P30519,Q9H7Z7,Q9NP58 Functions GO Molecular function msigdb_gomf 34,414,37,524,10,517,658,174,175,236,378,93,158,447 236,37,174,1885,1357,175,665,93,517,1095,34,378,10,2181,414,966,2702,158,447,524,658,1277,1174 1.6093549777202447,3.314313786509081,1.9385192969684373,-0.2252475557449799,0.04856032582182117,1.9385192969684373,0.6055828069993638,2.4535901140386045,0.8134720365945656,0.21206060116262693,3.4629394454457536,1.1417856605713883,4.231204838358074,-0.333399306791712,1.0519984666463416,0.31242405485919195,-0.5323126699925248,2.034660375542446,0.9794004819604001,0.8134720365945656,0.6247218507870246,0.11030317972784781,0.17152746597699287 3643 Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 12 20 3.3951980792687486 0.0006857896551337 P14314,P07942,P05067,Q07065,Q13217,P07237,Q02818,Q15293,O43852,Q5JRA6,P14625,Q9BTY2 Processes and pathways Reactome Pathways msigdb_reactome 324,196,385,100,166,41,74,203,16,342,184,90 2908,16,780,385,41,196,580,324,184,1089,74,642,100,166,419,203,342,1418,3018,90 -0.6452882514774274,4.095354306912875,0.4506749437853009,1.1239123190922105,3.2870083892475765,1.824865383027324,0.71968985939333,1.3008013122061457,1.8900097097013104,0.21206060116262693,2.633054429019238,0.6438120248840904,2.423291779810149,1.9706953778300438,1.0339137070490352,1.792091065872174,1.2481603149029503,0.027862332156932304,-0.6909922588809689,2.4988272513624805 3643 Response to endoplasmic reticulum stress 35 96 3.393634136514431 0.0006897177112683 Q8IXB1,Q9UM00,P30040,P51572,P16615,Q9UBV2,Q7Z2K6,Q96HE7,Q4ZIN3,Q9Y4L1,Q9UKV5,Q13217,P07237,Q9H3N1,Q9NYU2,P14625,P13667,Q96A33,O60858,Q9Y4P3,O75477,O95831,Q92905,Q8TCJ2,Q9UBU6,O94905,P41440,Q6ZXV5,Q13438,P30101,Q8TCT9,O95881,P27824,Q9BUN8,Q9BS26 Processes and pathways GO Biological process msigdb_gobp 129,259,386,397,267,143,147,411,27,416,169,166,41,297,306,184,443,188,60,193,322,195,77,336,82,334,213,214,91,352,364,237,118,122,251 1084,1052,3617,469,755,1484,847,60,322,1213,780,1214,334,2990,707,2035,195,237,1734,1355,41,1054,443,184,3608,267,1402,2258,539,118,386,352,2260,1736,213,1631,1742,397,3004,2552,1525,625,2772,739,3089,3356,1224,2501,1999,166,91,1227,2278,3169,3382,27,3098,1193,214,585,147,129,836,3505,336,364,1764,1817,77,188,1903,2067,411,890,3323,3567,251,122,3178,2839,297,1914,1315,306,82,143,169,259,799,2651,3304,2080,1689,416,193,2472 0.21206060116262693,0.23224335926748166,-2.0288519737109936,0.9061027846832771,0.4897054676751104,-0.013711595274741894,0.3917410017874763,2.866397368803325,1.3008013122061457,0.13076838476814698,0.4506749437853009,0.13076838476814698,1.2657472734377568,-0.6909922588809689,0.5478694768628188,-0.28994201948861137,1.824865383027324,1.6093549777202447,-0.16113177748554827,0.04856032582182117,3.2870083892475765,0.23224335926748166,0.9794004819604001,1.8900097097013104,-1.8632698976234066,1.5078566888617457,0.027862332156932304,-0.37712313988404206,0.776099228012361,2.285531889164803,1.1239123190922105,1.2128654372087189,-0.37712313988404206,-0.16113177748554827,1.692943464578411,-0.09758260109774661,-0.16113177748554827,1.105997161876891,-0.6909922588809689,-0.48762464822389984,-0.03458833609287247,0.6628536231131278,-0.5772854996002308,0.5091440599781275,-0.7369966820229626,-0.9716940090710073,0.13076838476814698,-0.465386116003162,-0.2683121372291175,1.9706953778300438,2.483776090582276,0.13076838476814698,-0.37712313988404206,-0.7833062289105431,-0.9956073764657654,3.569421755662869,-0.7369966820229626,0.15117635458958095,1.692943464578411,0.71968985939333,2.0981172248521958,2.223543950079106,0.4114378359281686,-1.1899723271023945,1.2657472734377568,1.1774078138827289,-0.16113177748554827,-0.18244015934691968,2.6034158117050517,1.8575044941143102,-0.2252475557449799,-0.28994201948861137,1.0700404706148139,0.37199154172998977,-0.9241144775154201,-1.390041774081608,1.592529825004484,2.254597454452404,-0.7833062289105431,-0.5998800653389513,1.4050196301598754,-0.2252475557449799,0.08978035873173802,1.3877470096535027,2.5587558625495044,2.1296580535061174,1.9706953778300438,1.5587706046077934,0.4506749437853009,-0.5099333245444402,-0.900446979133231,-0.28994201948861137,-0.11870343366061006,1.0519984666463416,1.8412017569470738,-0.44321720897869366 3643 Hexosyltransferase activity 24 42 3.3632404596370327 0.0007703323303325 O60512,P04843,P04844,Q16739,Q9H488,P46977,Q7Z4H8,Q9BT22,Q8NAT1,Q9NYU2,Q9Y2G5,Q8N4A0,P04062,O15294,Q8TCJ2,Q10472,Q6ZXV5,Q9P2E5,Q02809,Q93063,Q9BV10,Q96L58,Q16880,O60568 Functions GO Molecular function msigdb_gomf 253,384,395,282,674,152,283,161,46,306,53,180,449,328,336,210,214,608,613,359,633,631,246,493 822,328,662,253,493,2801,2602,2805,449,384,395,1325,1356,3508,2364,954,1551,1057,2216,1671,152,613,1750,210,831,282,246,214,283,765,180,46,919,336,359,631,161,633,674,306,608,53 0.4114378359281686,1.2832942009953483,0.6055828069993638,1.5756684289722063,0.850660633843561,-0.5998800653389513,-0.5099333245444402,-0.5998800653389513,0.9611422765478006,1.1239123190922105,1.105997161876891,0.06919953703395551,0.04856032582182117,-1.2146610216914933,-0.42111741427401633,0.31242405485919195,-0.055525473592154824,0.23224335926748166,-0.3552276637336356,-0.11870343366061006,2.06645172244257,0.6818469365208409,-0.16113177748554827,1.7095549611048153,0.4114378359281686,1.4566081122737937,1.592529825004484,1.692943464578411,1.4566081122737937,0.4897054676751104,1.9062125107768622,3.190737263872994,0.3521891223123161,1.2657472734377568,1.1951570795527422,0.6628536231131278,2.018717139797755,0.6628536231131278,0.6055828069993638,1.3877470096535027,0.7007922534137548,3.0230894408053492 3643 Oxidative phosphorylation 33 70 3.360688142498729 0.0007774855772664 O75438,P13073,O14949,P20674,O75380,P14406,P03886,O75306,O96000,O95139,O75323,P47985,O95169,O43676,Q9Y6M9,P22695,O75489,Q9BSK2,Q9UDW1,O43674,Q9H3K2,O95168,Q9UJZ1,P00403,O95167,O14548,P06576,P24539,O75964,O00217,O75251,P56556,Q7KZN9 Processes and pathways GO Biological process msigdb_gobp 768,515,137,651,650,28,277,535,664,548,547,808,806,50,183,563,696,327,198,321,468,470,609,87,341,717,92,362,110,734,366,624,378 734,1875,717,137,321,50,2358,366,535,547,650,768,696,1138,110,548,341,470,806,1515,2155,664,1885,87,1000,277,953,1251,92,1357,2363,1252,515,28,1056,1218,1932,3080,651,563,362,1517,1294,2605,2818,1405,881,827,1141,1668,808,3463,3129,2552,1258,931,624,1498,2280,2125,378,1684,3567,2072,1427,327,468,198,609,183 0.5091440599781275,-0.2252475557449799,0.5285319592869173,2.1453820763492155,1.3008013122061457,3.107332731050088,-0.42111741427401633,1.1596174162013977,0.776099228012361,0.7573430676997512,0.6247218507870246,0.4702158680735321,0.5671569209643074,0.17152746597699287,2.3623540515125967,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.6055828069993638,-0.2252475557449799,2.5138506890054337,0.2724430641772754,1.4566081122737937,0.31242405485919195,0.11030317972784781,2.4535901140386045,0.04856032582182117,-0.42111741427401633,0.11030317972784781,0.8134720365945656,3.5429255537908872,0.23224335926748166,0.13076838476814698,-0.24674747021415624,-0.7369966820229626,0.6247218507870246,0.7385400373905193,1.1774078138827289,-0.03458833609287247,0.08978035873173802,-0.5099333245444402,-0.5998800653389513,0.027862332156932304,0.37199154172998977,0.4114378359281686,0.17152746597699287,-0.11870343366061006,0.4310823742970927,-1.1164377040450824,-0.7601130162085916,-0.48762464822389984,0.11030317972784781,0.33233340674752826,0.6628536231131278,-0.013711595274741894,-0.37712313988404206,-0.3116375849262432,1.1417856605713883,-0.11870343366061006,-1.390041774081608,-0.28994201948861137,0.027862332156932304,1.3008013122061457,0.9244936801618757,1.824865383027324,0.7007922534137548,1.9062125107768622 3643 EF-Hand 1, calcium-binding site [IPR018247] 9 41 3.3382736426137463 0.0008430068441285 Q9Y680,Q9NWM8,Q9BRK5,Q02818,P80303,Q96AY3,O43852,Q14257,Q8NI22 Sequence InterPro Binding site interpro_binding_site 39,8,105,74,43,75,16,20,22 778,16,2602,1733,1028,2092,3159,1930,977,3605,324,3336,1292,2160,2161,1520,1630,1182,43,74,3574,1300,20,3093,203,1269,1760,1643,22,75,1501,1906,105,1776,1912,8,692,1721,971,1831,39 0.4506749437853009,4.095354306912875,-0.5099333245444402,-0.16113177748554827,0.25237072765834473,-0.3116375849262432,-0.7833062289105431,-0.24674747021415624,0.29246072303462184,-1.808991775160554,1.3008013122061457,-0.947863266551478,0.08978035873173802,-0.333399306791712,-0.333399306791712,-0.03458833609287247,-0.09758260109774661,0.15117635458958095,3.2321311079528603,2.633054429019238,-1.4409977440294737,0.08978035873173802,3.8042718536546554,-0.7369966820229626,1.792091065872174,0.11030317972784781,-0.16113177748554827,-0.09758260109774661,3.7655729970606435,2.633054429019238,-0.013711595274741894,-0.2252475557449799,2.3928800946790516,-0.16113177748554827,-0.2252475557449799,4.352908051790398,0.5863945968863824,-0.13988634815318823,0.31242405485919195,-0.18244015934691968,3.314313786509081 3643 N glycan trimming in the er and calnexin calreticulin cycle 12 17 3.335894053560103 0.0008502555997771 P14314,P30101,Q13724,Q9UKV5,Q14165,Q9UBV2,Q9NYU2,P27824,Q9BUN8,Q13438,O60858,Q14697 Processes and pathways Reactome Pathways msigdb_reactome 324,352,356,169,486,143,306,118,122,91,60,445 60,324,539,118,352,1524,2552,2429,1224,91,356,486,445,122,306,143,169 2.866397368803325,1.3008013122061457,0.776099228012361,2.285531889164803,1.2128654372087189,-0.03458833609287247,-0.48762464822389984,-0.44321720897869366,0.13076838476814698,2.483776090582276,1.1951570795527422,0.8691865207095048,0.9794004819604001,2.254597454452404,1.3877470096535027,2.1296580535061174,1.9706953778300438 3643 Glycosyltransferase 13 25 3.327811484447357 0.0008753107590664 O60512,Q9BT22,P04843,Q93063,Q8TCJ2,Q8NAT1,Q8N128,Q9NYU2,Q10472,Q16739,Q9Y2G5,Q8N4A0,P46977 Drugs and Diseases Pharos Drug Target Ontology pharos_dto 253,161,384,359,336,46,369,306,210,282,53,180,152 253,2801,2805,384,395,1551,2216,1030,1671,152,3544,1750,210,282,765,369,180,46,336,359,161,633,306,608,53 1.5756684289722063,-0.5998800653389513,-0.5998800653389513,1.1239123190922105,1.105997161876891,-0.055525473592154824,-0.3552276637336356,0.25237072765834473,-0.11870343366061006,2.06645172244257,-1.2892692909305767,-0.16113177748554827,1.7095549611048153,1.4566081122737937,0.4897054676751104,1.1596174162013977,1.9062125107768622,3.190737263872994,1.2657472734377568,1.1951570795527422,2.018717139797755,0.6628536231131278,1.3877470096535027,0.7007922534137548,3.0230894408053492 3643 Mitochondrial protein import 15 38 3.3177081320351727 0.0009075926864696 Q13505,Q9Y5J9,Q99595,O60830,Q5JRX3,Q15388,Q9Y5J7,Q9Y512,Q9Y584,Q9NX63,Q8N4H5,Q3ZCQ8,P06576,P21796,Q9NS69 Processes and pathways Reactome Pathways msigdb_reactome 519,392,2,0,35,201,433,575,308,544,56,566,92,278,63 754,825,0,2714,1695,879,1733,1106,806,697,92,1357,2994,581,904,278,1517,2720,1144,1093,519,201,566,35,56,2,2585,1046,63,544,1434,1436,575,308,751,433,392,1020 0.4897054676751104,0.4114378359281686,5.89350676912575,-0.5547632158192415,-0.13988634815318823,0.37199154172998977,-0.16113177748554827,0.1918220918189678,0.4310823742970927,0.5671569209643074,2.4535901140386045,0.04856032582182117,-0.6909922588809689,0.71968985939333,0.3521891223123161,1.4566081122737937,-0.03458833609287247,-0.5547632158192415,0.17152746597699287,0.21206060116262693,0.8134720365945656,1.8084952079083476,0.7385400373905193,3.4495350664729076,2.9664513233824246,5.347123193165582,-0.48762464822389984,0.25237072765834473,2.837587540785622,0.776099228012361,0.027862332156932304,0.027862332156932304,0.7385400373905193,1.3704358233118867,0.5091440599781275,1.0157859516403132,1.1239123190922105,0.2724430641772754 3643 protein modifying enzyme 16 29 3.309188751200195 0.000935667349065 Q9UMR5,Q12797,O75718,O15460,Q02809,O15294,Q6PK18,P13674,O60476,Q92791,Q15418,P50897,O60568,Q86X55,Q86YN1,O60725 Functions Panther Protein class panther_protein_class 66,481,99,194,613,328,271,47,545,113,495,244,493,568,155,62 822,1577,328,194,545,493,1441,62,99,47,1057,1736,244,1003,855,613,481,1458,495,3099,271,568,155,919,113,3207,674,66,3149 0.4114378359281686,-0.0765234222627171,1.2832942009953483,1.824865383027324,0.7573430676997512,0.850660633843561,0.007105158915106008,2.837587540785622,2.423291779810149,3.163027731650402,0.23224335926748166,-0.16113177748554827,1.592529825004484,0.2724430641772754,0.3917410017874763,0.6818469365208409,0.8876671508686171,0.007105158915106008,0.850660633843561,-0.7369966820229626,1.4908112708908634,0.7385400373905193,2.050571853401436,0.3521891223123161,2.3470478270665613,-0.8065769270037231,0.6055828069993638,2.808677111591547,-0.7601130162085916 3643 Steroid binding 13 24 3.2867163572761653 0.0010136287486988 O75477,O15173,P45880,P04062,P30536,O95772,O00264,P61916,P38435,O94905,Q9H4L5,Q14108,P21796 Functions GO Molecular function msigdb_gomf 322,37,261,449,106,394,236,466,80,334,345,444,278 236,2416,37,322,334,394,449,976,3079,278,2488,2316,106,783,80,261,466,444,555,1963,1774,1607,1470,345 1.6093549777202447,-0.44321720897869366,3.314313786509081,1.3008013122061457,1.2657472734377568,1.105997161876891,0.9611422765478006,0.29246072303462184,-0.7369966820229626,1.4566081122737937,-0.465386116003162,-0.39908622494449625,2.377631431346862,0.4506749437853009,2.5587558625495044,1.5418361654019872,0.9244936801618757,0.9794004819604001,0.7573430676997512,-0.24674747021415624,-0.16113177748554827,-0.0765234222627171,0.007105158915106008,1.2481603149029503 3643 Intrinsic component of mitochondrial membrane 30 55 3.284747719890864 0.001020737237064 Q13505,O60830,Q99595,Q8IVP5,Q9NWR8,Q9NX63,Q8N8Q8,Q5XKP0,Q9UG56,Q9Y3D6,Q9Y512,Q16891,Q9NP58,O96008,Q15070,Q15388,P50416,P12235,Q9H4I9,Q6P4A7,Q9H3K2,O43819,Q9Y2R0,O75880,Q9GZY8,Q9Y4W6,Q9HC21,P57105,Q9BUB7,P0DJ07 Localization GO Cellular component msigdb_gocc 519,0,2,645,659,544,285,670,159,173,575,700,447,697,200,201,709,581,78,725,468,333,86,718,220,620,619,232,490,756 754,333,0,1695,718,1106,999,1580,697,756,581,2720,1184,709,232,2222,519,200,201,2625,3382,700,1896,670,725,1010,645,1760,1643,285,1159,3633,2583,2,1906,490,1966,1469,220,468,78,1313,1101,619,447,2074,1278,659,544,159,2898,86,173,620,575 0.4897054676751104,1.2657472734377568,5.89350676912575,-0.13988634815318823,0.5285319592869173,0.1918220918189678,0.2724430641772754,-0.0765234222627171,0.5671569209643074,0.4897054676751104,0.71968985939333,-0.5547632158192415,0.15117635458958095,0.5478694768628188,1.6261440706577892,-0.3552276637336356,0.8134720365945656,1.8084952079083476,1.8084952079083476,-0.5099333245444402,-0.9956073764657654,0.5671569209643074,-0.2252475557449799,0.6055828069993638,0.5285319592869173,0.2724430641772754,0.6438120248840904,-0.16113177748554827,-0.09758260109774661,1.4566081122737937,0.17152746597699287,-3.0906760096205748,-0.48762464822389984,5.347123193165582,-0.2252475557449799,0.8691865207095048,-0.24674747021415624,0.007105158915106008,1.659614804060893,0.9244936801618757,2.6034158117050517,0.08978035873173802,0.21206060116262693,0.6818469365208409,0.9794004819604001,-0.28994201948861137,0.11030317972784781,0.6247218507870246,0.776099228012361,2.034660375542446,-0.6225474635721432,2.5288465238651407,1.9546235974626718,0.6818469365208409,0.7385400373905193 3643 Peptidyl proline modification 9 37 3.2729558755857986 0.0010642909081033 O75718,Q9Y680,Q9NWM8,P07237,Q13162,Q96AY3,Q32P28,P13674,Q9BV86 Processes and pathways GO Biological process msigdb_gobp 99,39,8,41,72,75,12,47,126 733,194,3348,99,41,47,2667,757,2818,906,1740,1032,1362,2680,2111,3050,72,1190,1595,2685,3136,2567,1894,12,2123,2781,1763,75,3292,411,126,1346,8,3241,1131,1576,39 0.5091440599781275,1.824865383027324,-0.9716940090710073,2.423291779810149,3.2870083892475765,3.163027731650402,-0.5323126699925248,0.4897054676751104,-0.5998800653389513,0.3521891223123161,-0.16113177748554827,0.25237072765834473,0.04856032582182117,-0.5323126699925248,-0.3116375849262432,-0.7139566269396745,2.692012537294508,0.15117635458958095,-0.0765234222627171,-0.5323126699925248,-0.7601130162085916,-0.48762464822389984,-0.2252475557449799,4.206660830311199,-0.3116375849262432,-0.5772854996002308,-0.16113177748554827,2.633054429019238,-0.900446979133231,1.0700404706148139,2.239085653646518,0.06919953703395551,4.352908051790398,-0.829925724951396,0.1918220918189678,-0.055525473592154824,3.314313786509081 3643 Electron transport chain 36 75 3.2689307710563265 0.0010795471121367 O75438,P13073,O14949,P20674,O75380,P30038,P21912,P03886,O75306,O96000,O95139,P47985,O43676,Q9Y6M9,O75489,Q9UDW1,O43674,P16435,O15460,P04062,Q9H3K2,O43819,O95168,P00403,O95167,Q13630,O14548,Q12797,Q14554,P23378,O00217,O75251,P48163,P56556,Q7KZN9,P23368 Processes and pathways GO Biological process msigdb_gobp 768,515,137,651,650,407,538,277,535,664,548,808,50,183,696,198,321,71,194,449,468,333,470,87,341,475,717,481,108,735,734,366,760,624,378,119 734,1875,717,137,194,1880,3121,321,50,2358,333,1693,366,535,650,768,696,1733,548,341,470,806,1515,2155,664,2255,1885,87,277,953,449,2662,1087,1251,1357,1838,2363,1252,3124,515,3334,1056,3220,1218,71,3080,651,538,119,735,2605,407,1405,2607,1182,808,760,3129,624,481,475,108,1118,2625,1498,2280,2741,378,3567,3403,468,1349,198,1434,183 0.5091440599781275,-0.2252475557449799,0.5285319592869173,2.1453820763492155,1.824865383027324,-0.2252475557449799,-0.7601130162085916,1.3008013122061457,3.107332731050088,-0.42111741427401633,1.2657472734377568,-0.13988634815318823,1.1596174162013977,0.776099228012361,0.6247218507870246,0.4702158680735321,0.5671569209643074,-0.16113177748554827,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.6055828069993638,-0.37712313988404206,-0.2252475557449799,2.5138506890054337,1.4566081122737937,0.31242405485919195,0.9611422765478006,-0.5323126699925248,0.21206060116262693,0.11030317972784781,0.04856032582182117,-0.2038119362780547,-0.42111741427401633,0.11030317972784781,-0.7601130162085916,0.8134720365945656,-0.947863266551478,0.23224335926748166,-0.829925724951396,0.13076838476814698,2.7213338218562386,-0.7369966820229626,0.6247218507870246,0.776099228012361,2.2700794880847806,0.5091440599781275,-0.5099333245444402,1.0700404706148139,0.027862332156932304,-0.5099333245444402,0.15117635458958095,0.4310823742970927,0.4897054676751104,-0.7601130162085916,0.6628536231131278,0.8876671508686171,0.9061027846832771,2.377631431346862,0.1918220918189678,-0.5099333245444402,-0.013711595274741894,-0.37712313988404206,-0.5547632158192415,1.1417856605713883,-1.390041774081608,-1.019604048841438,0.9244936801618757,0.06919953703395551,1.824865383027324,0.027862332156932304,1.9062125107768622 3643 Protein transmembrane transport 14 31 3.247920345950453 0.0011625180995991 O60830,Q07820,Q99595,O95831,P49755,Q15388,P31751,P61619,O75298,Q15629,Q99442,Q9Y584,Q9UGP8,Q9NS69 Processes and pathways GO Biological process msigdb_gobp 0,553,2,195,225,201,550,363,546,112,467,308,221,63 695,754,825,0,546,1137,1106,195,697,2994,1217,550,225,1522,2611,2772,2496,363,553,3378,201,112,566,1307,1373,467,2,1046,63,221,308 0.5671569209643074,0.4897054676751104,0.4114378359281686,5.89350676912575,0.7573430676997512,0.17152746597699287,0.1918220918189678,1.824865383027324,0.5671569209643074,-0.6909922588809689,0.13076838476814698,0.7573430676997512,1.64289728589414,-0.03458833609287247,-0.5099333245444402,-0.5772854996002308,-0.465386116003162,1.1774078138827289,0.7573430676997512,-0.9956073764657654,1.8084952079083476,2.3470478270665613,0.7385400373905193,0.08978035873173802,0.04856032582182117,0.9244936801618757,5.347123193165582,0.25237072765834473,2.837587540785622,1.659614804060893,1.3704358233118867 3643 Oxidative phosphorylation 32 69 3.242521496726713 0.0011847701000411 O75438,P13073,O14949,P20674,O75380,P21912,P14406,P03886,O75306,O96000,Q15904,O95139,P47985,O43676,Q9Y6M9,P22695,O75489,Q9UDW1,O43674,O95168,P00403,O95167,O14548,P06576,P24539,O75964,O00217,Q9Y487,O75251,P56556,Q7KZN9,Q86Y39 Processes and pathways KEGG Pathways msigdb_kegg 768,515,137,651,650,538,28,277,535,664,815,548,808,50,183,563,696,198,321,470,87,341,717,92,362,110,734,502,366,624,378,497 734,1875,717,137,321,50,2358,366,535,650,768,696,1138,110,548,341,470,806,1515,2155,664,1885,87,1000,277,953,92,1357,1583,1252,515,28,1056,1218,1932,3080,651,2855,3310,538,563,362,1517,2605,1405,881,1141,1059,1588,808,3463,3129,1258,931,624,1222,3584,815,1498,2280,378,497,1162,2840,198,1870,502,1512,183 0.5091440599781275,-0.2252475557449799,0.5285319592869173,2.1453820763492155,1.3008013122061457,3.107332731050088,-0.42111741427401633,1.1596174162013977,0.776099228012361,0.6247218507870246,0.4702158680735321,0.5671569209643074,0.17152746597699287,2.3623540515125967,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.6055828069993638,-0.2252475557449799,2.5138506890054337,0.2724430641772754,1.4566081122737937,0.31242405485919195,2.4535901140386045,0.04856032582182117,-0.0765234222627171,0.11030317972784781,0.8134720365945656,3.5429255537908872,0.23224335926748166,0.13076838476814698,-0.24674747021415624,-0.7369966820229626,0.6247218507870246,-0.6225474635721432,-0.9241144775154201,0.776099228012361,0.7385400373905193,1.1774078138827289,-0.03458833609287247,-0.5099333245444402,0.027862332156932304,0.37199154172998977,0.17152746597699287,0.23224335926748166,-0.0765234222627171,0.4310823742970927,-1.1164377040450824,-0.7601130162085916,0.11030317972784781,0.33233340674752826,0.6628536231131278,0.13076838476814698,-1.5181631738777326,0.4310823742970927,-0.013711595274741894,-0.37712313988404206,1.1417856605713883,0.850660633843561,0.17152746597699287,-0.5998800653389513,1.824865383027324,-0.2038119362780547,0.850660633843561,-0.013711595274741894,1.9062125107768622 3643 Protein localization to mitochondrion 19 66 3.2358740041986995 0.0012127090030478 O60830,Q9Y5J9,Q99595,P55786,P51572,Q9Y6C9,O00165,Q8N8Q8,Q5JRX3,Q9Y3D6,Q9Y584,Q8N4H5,Q9NS69,O95831,Q15070,Q15388,Q9GZY8,P30536,P49257 Processes and pathways GO Biological process msigdb_gobp 0,392,2,138,397,266,382,285,35,173,308,56,63,195,200,201,220,106,238 382,733,2982,1249,753,754,825,0,879,1106,999,3331,849,3507,195,697,2361,1930,2994,2094,2486,2487,3188,106,1587,2770,3312,238,2044,397,1257,138,2776,1093,200,201,2624,566,1896,35,1680,56,285,965,2746,2,866,2526,220,795,1046,63,945,1349,3212,1105,1436,3541,173,575,308,751,433,392,1020,266 1.1239123190922105,0.5091440599781275,-0.6909922588809689,0.11030317972784781,0.4897054676751104,0.4897054676751104,0.4114378359281686,5.89350676912575,0.37199154172998977,0.1918220918189678,0.2724430641772754,-0.947863266551478,0.3917410017874763,-1.2146610216914933,1.824865383027324,0.5671569209643074,-0.42111741427401633,-0.24674747021415624,-0.6909922588809689,-0.3116375849262432,-0.465386116003162,-0.465386116003162,-0.8065769270037231,2.377631431346862,-0.0765234222627171,-0.5772854996002308,-0.9241144775154201,1.6093549777202447,-0.28994201948861137,1.105997161876891,0.11030317972784781,2.1453820763492155,-0.5772854996002308,0.21206060116262693,1.8084952079083476,1.8084952079083476,-0.5099333245444402,0.7385400373905193,-0.2252475557449799,3.4495350664729076,-0.11870343366061006,2.9664513233824246,1.4566081122737937,0.31242405485919195,-0.5547632158192415,5.347123193165582,0.3917410017874763,-0.465386116003162,1.659614804060893,0.4506749437853009,0.25237072765834473,2.837587540785622,0.33233340674752826,0.06919953703395551,-0.8065769270037231,0.21206060116262693,0.027862332156932304,-1.2643087218937006,1.9546235974626718,0.7385400373905193,1.3704358233118867,0.5091440599781275,1.0157859516403132,1.1239123190922105,0.2724430641772754,1.5248649233353988 3643 Anion transmembrane transport 23 50 3.223023850737184 0.0012684499141539 P45880,P30825,Q9Y277,Q9UBX3,Q8TB61,P53985,Q9H2D1,O43808,P21796,Q9Y619,Q14728,P08183,Q86VD7,P55011,O60831,P51797,P04920,P12235,Q02978,Q9UHG3,P41440,Q9HC21,Q01650 Processes and pathways GO Biological process msigdb_gobp 261,771,661,144,410,409,286,779,278,694,814,303,177,678,434,191,450,581,79,84,213,619,376 1176,779,434,1733,1883,1580,450,1581,1445,303,1400,581,904,278,771,2318,213,261,1942,191,2219,1491,409,678,2222,376,79,1638,814,915,1301,960,177,1233,410,2180,2583,1014,286,1313,619,1103,144,84,1434,661,2030,694,1287,846 0.15117635458958095,0.4506749437853009,0.99761495810321,-0.16113177748554827,-0.2252475557449799,-0.0765234222627171,0.9611422765478006,-0.0765234222627171,0.007105158915106008,1.3877470096535027,0.027862332156932304,0.71968985939333,0.3521891223123161,1.4566081122737937,0.4702158680735321,-0.39908622494449625,1.692943464578411,1.5418361654019872,-0.24674747021415624,1.8412017569470738,-0.3552276637336356,-0.013711595274741894,1.0700404706148139,0.5863945968863824,-0.3552276637336356,1.1417856605713883,2.5885562139486704,-0.09758260109774661,0.4310823742970927,0.3521891223123161,0.08978035873173802,0.31242405485919195,1.9223823204371768,0.13076838476814698,1.0700404706148139,-0.333399306791712,-0.48762464822389984,0.2724430641772754,1.4566081122737937,0.08978035873173802,0.6818469365208409,0.21206060116262693,2.1296580535061174,2.5587558625495044,0.027862332156932304,0.6247218507870246,-0.2683121372291175,0.5863945968863824,0.11030317972784781,0.4114378359281686 3643 Protein transporter activity 9 18 3.221634937680246 0.0012746142647015 O60830,Q99595,P49755,Q9HD20,Q15388,P61619,Q9Y584,Q9UGP8,Q9NS69 Functions GO Molecular function msigdb_gomf 0,2,225,136,201,363,308,221,63 695,754,0,1106,697,225,2611,363,553,201,2012,2,136,63,221,308,751,392 0.5671569209643074,0.4897054676751104,5.89350676912575,0.1918220918189678,0.5671569209643074,1.64289728589414,-0.5099333245444402,1.1774078138827289,0.7573430676997512,1.8084952079083476,-0.2683121372291175,5.347123193165582,2.1610753620574217,2.837587540785622,1.659614804060893,1.3704358233118867,0.5091440599781275,1.1239123190922105 3643 Primary mitochondrial disease 54 110 3.22042055298272 0.0012800266622314 Q8NFF5,P13073,O14949,P39210,Q9UBX3,P20674,O75380,Q07021,Q5XKP0,Q96CU9,P03886,O75306,P47985,O95169,O43676,Q9Y584,Q9Y6M9,Q5JTZ9,P22695,Q8NI60,O75489,Q86YH6,Q5JPH6,O95831,P08559,Q6DKK2,P12235,Q6P4A7,Q8IUX1,Q99797,O43819,Q9NWS8,Q7LG56,Q9Y2R0,P00403,Q96RR1,Q5ST30,O75880,Q8N183,P82650,O60313,Q70HW3,Q9BUB7,Q9H3H1,O75251,O00217,Q9H9J2,P56556,Q7KZN9,Q86Y39,P0DJ07,Q9H0R6,Q5T2R2,Q9BW92 Drugs and Diseases Protein Atlas Disease involvement protein_atlas_disease_involvement 388,515,137,505,144,651,650,653,670,413,277,535,808,806,50,308,183,567,563,446,696,197,834,195,451,332,581,725,865,866,333,607,864,86,87,603,722,718,602,473,847,357,490,634,366,734,372,624,378,497,756,510,644,648 734,1875,137,50,2358,333,847,366,535,650,696,1323,718,806,2155,195,1885,87,1000,277,953,451,1357,1582,756,581,515,1056,3080,651,563,1517,2605,1405,505,1521,1939,808,2322,3129,1328,2045,1221,624,473,1747,1188,653,2280,1896,834,567,722,644,2509,670,332,725,357,378,2390,864,497,197,865,602,2062,388,446,1309,1961,1861,413,1163,1683,1863,1240,603,866,2234,1014,1427,2235,490,648,510,634,993,372,1017,607,2405,1652,1508,1349,3302,144,1389,897,1436,1788,86,1284,1923,2755,1018,1437,308,1925,183 0.5091440599781275,-0.2252475557449799,2.1453820763492155,3.107332731050088,-0.42111741427401633,1.2657472734377568,0.3917410017874763,1.1596174162013977,0.776099228012361,0.6247218507870246,0.5671569209643074,0.06919953703395551,0.5285319592869173,0.4310823742970927,-0.333399306791712,1.824865383027324,-0.2252475557449799,2.5138506890054337,0.2724430641772754,1.4566081122737937,0.31242405485919195,0.9611422765478006,0.04856032582182117,-0.0765234222627171,0.4897054676751104,0.71968985939333,0.8134720365945656,0.23224335926748166,-0.7369966820229626,0.6247218507870246,0.7385400373905193,-0.03458833609287247,-0.5099333245444402,0.027862332156932304,0.832089227524965,-0.03458833609287247,-0.24674747021415624,0.4310823742970927,-0.39908622494449625,-0.7601130162085916,0.06919953703395551,-0.28994201948861137,0.13076838476814698,0.6628536231131278,0.9061027846832771,-0.16113177748554827,0.15117635458958095,0.6247218507870246,-0.37712313988404206,-0.2252475557449799,0.4114378359281686,0.7385400373905193,0.5285319592869173,0.6438120248840904,-0.465386116003162,0.6055828069993638,1.2832942009953483,0.5285319592869173,1.1951570795527422,1.1417856605713883,-0.42111741427401633,0.3917410017874763,0.850660633843561,1.824865383027324,0.3917410017874763,0.7007922534137548,-0.28994201948861137,1.1239123190922105,0.9794004819604001,0.08978035873173802,-0.24674747021415624,-0.2038119362780547,1.0519984666463416,0.17152746597699287,-0.11870343366061006,-0.2038119362780547,0.13076838476814698,0.7007922534137548,0.3917410017874763,-0.3552276637336356,0.2724430641772754,0.027862332156932304,-0.3552276637336356,0.8691865207095048,0.6438120248840904,0.832089227524965,0.6628536231131278,0.29246072303462184,1.1596174162013977,0.2724430641772754,0.7007922534137548,-0.42111741427401633,-0.09758260109774661,-0.013711595274741894,0.06919953703395551,-0.900446979133231,2.1296580535061174,0.04856032582182117,0.37199154172998977,0.027862332156932304,-0.16113177748554827,2.5288465238651407,0.11030317972784781,-0.2252475557449799,-0.5547632158192415,0.2724430641772754,0.027862332156932304,1.3704358233118867,-0.2252475557449799,1.9062125107768622 3643 Metalloprotease 11 28 3.213182869519471 0.0013127267870896 Q9UIQ6,P78536,Q5JRX3,Q9NQW7,Q6P179,P55786,Q9BYT8,Q92905,Q7Z2K6,O75844,Q9NZ08 Functions Protein Atlas Molecular function protein_atlas_molecular_function 230,226,35,38,103,138,141,77,147,217,127 900,578,879,217,3530,1442,1663,2483,1401,955,325,138,226,35,103,147,77,938,841,866,141,3614,591,38,2024,127,230,620 0.3521891223123161,0.71968985939333,0.37199154172998977,1.659614804060893,-1.2643087218937006,0.007105158915106008,-0.11870343366061006,-0.465386116003162,0.027862332156932304,0.31242405485919195,1.3008013122061457,2.1453820763492155,1.64289728589414,3.4495350664729076,2.3928800946790516,2.0981172248521958,2.6034158117050517,0.33233340674752826,0.4114378359281686,0.3917410017874763,2.1296580535061174,-1.9455372097525145,0.71968985939333,3.314313786509081,-0.2683121372291175,2.239085653646518,1.64289728589414,0.6818469365208409 3643 Sphingolipid metabolic process 19 34 3.209870975897377 0.0013279456511117 O60512,P27544,P17900,Q6Y1H2,Q16739,P06280,Q96G23,P04062,Q9P035,Q9H2C2,O95470,Q06136,Q9NZJ7,Q8NCC3,P07602,P50897,Q16880,Q9NWW5,Q9NRA0 Processes and pathways GO Biological process msigdb_gobp 253,5,516,529,282,549,55,449,340,337,209,347,492,358,231,244,246,252,257 611,1879,253,209,449,549,1356,231,3508,1886,516,2488,5,2259,244,3049,347,3358,282,246,1896,529,358,55,1165,337,257,252,1130,798,3210,492,340,1785 0.6818469365208409,-0.2252475557449799,1.5756684289722063,1.7095549611048153,0.9611422765478006,0.7573430676997512,0.04856032582182117,1.6261440706577892,-1.2146610216914933,-0.2252475557449799,0.8134720365945656,-0.465386116003162,4.73149126850177,-0.37712313988404206,1.592529825004484,-0.7139566269396745,1.2305331089305223,-0.9716940090710073,1.4566081122737937,1.592529825004484,-0.2252475557449799,0.7948087934495096,1.1951570795527422,2.980646976640566,0.17152746597699287,1.2657472734377568,1.5756684289722063,1.592529825004484,0.1918220918189678,0.4506749437853009,-0.8065769270037231,0.8691865207095048,1.2657472734377568,-0.16113177748554827 3643 Mitochondrial carrier domain superfamily [IPR023395] 13 24 3.193375542883229 0.0014061993897747 Q9BSK2,O43772,Q9HC21,Q70HW3,Q9NZJ7,Q9Y6C9,Q9Y619,P12235,Q02978,Q9UBX3,Q86VD7,Q9H2D1,Q96H78 Sequence InterPro Superfamily interpro_homologous_superfamily 327,663,619,357,492,266,694,581,79,144,177,286,216 663,779,1733,1581,581,904,1491,2222,79,701,1269,357,177,2179,216,1014,327,286,619,492,144,1434,694,266 0.6055828069993638,0.4506749437853009,-0.16113177748554827,-0.0765234222627171,0.71968985939333,0.3521891223123161,-0.013711595274741894,-0.3552276637336356,2.5885562139486704,0.5671569209643074,0.11030317972784781,1.1951570795527422,1.9223823204371768,-0.333399306791712,1.6762968043598454,0.2724430641772754,1.3008013122061457,1.4566081122737937,0.6818469365208409,0.8691865207095048,2.1296580535061174,0.027862332156932304,0.5863945968863824,1.5248649233353988 3643 SLC25 family of mitochondrial transporters 13 24 3.193375542883229 0.0014061993897747 Q9BSK2,O43772,Q9HC21,Q70HW3,Q9NZJ7,Q9Y6C9,Q9Y619,P12235,Q02978,Q9UBX3,Q86VD7,Q9H2D1,Q96H78 Drugs and Diseases Pharos Drug Target Ontology pharos_dto 327,663,619,357,492,266,694,581,79,144,177,286,216 663,779,1733,1581,581,904,1491,2222,79,701,1269,357,177,2179,216,1014,327,286,619,492,144,1434,694,266 0.6055828069993638,0.4506749437853009,-0.16113177748554827,-0.0765234222627171,0.71968985939333,0.3521891223123161,-0.013711595274741894,-0.3552276637336356,2.5885562139486704,0.5671569209643074,0.11030317972784781,1.1951570795527422,1.9223823204371768,-0.333399306791712,1.6762968043598454,0.2724430641772754,1.3008013122061457,1.4566081122737937,0.6818469365208409,0.8691865207095048,2.1296580535061174,0.027862332156932304,0.5863945968863824,1.5248649233353988 3643 Mitochondrial substrate/solute carrier [IPR018108] 13 24 3.193375542883229 0.0014061993897747 Q9BSK2,O43772,Q9HC21,Q70HW3,Q9NZJ7,Q9Y6C9,Q9Y619,P12235,Q02978,Q9UBX3,Q86VD7,Q9H2D1,Q96H78 Sequence InterPro Repeat interpro_repeat 327,663,619,357,492,266,694,581,79,144,177,286,216 663,779,1733,1581,581,904,1491,2222,79,701,1269,357,177,2179,216,1014,327,286,619,492,144,1434,694,266 0.6055828069993638,0.4506749437853009,-0.16113177748554827,-0.0765234222627171,0.71968985939333,0.3521891223123161,-0.013711595274741894,-0.3552276637336356,2.5885562139486704,0.5671569209643074,0.11030317972784781,1.1951570795527422,1.9223823204371768,-0.333399306791712,1.6762968043598454,0.2724430641772754,1.3008013122061457,1.4566081122737937,0.6818469365208409,0.8691865207095048,2.1296580535061174,0.027862332156932304,0.5863945968863824,1.5248649233353988 3643 Thioredoxin, conserved site [IPR017937] 11 12 3.1655348489659887 0.0015479811773118 Q8IXB1,P30101,Q15084,O43396,P07237,Q9H3N1,Q14554,O95881,Q8NBS9,Q9H1E5,Q96JJ7 Sequence InterPro Conserved site interpro_conserved_site 129,352,419,383,41,297,108,237,402,181,350 383,237,41,443,352,108,419,129,402,350,181,297 1.1239123190922105,1.6093549777202447,3.2870083892475765,0.9794004819604001,1.2128654372087189,2.377631431346862,1.0339137070490352,2.223543950079106,1.0880399570282553,1.2305331089305223,1.9062125107768622,1.4050196301598754 3643 Nadh dehydrogenase complex assembly 22 36 3.1613798168878757 0.0015702360149254 Q7L592,O75438,Q9H061,Q96CU9,P03886,O75306,O96000,Q9NW81,O95139,O95169,O43676,Q9Y6M9,O75489,O43674,Q15070,O95168,O95167,Q8N183,O75251,O00217,P56556,Q86Y39 Processes and pathways GO Biological process msigdb_gobp 774,768,148,413,277,535,664,691,548,806,50,183,696,321,200,470,341,602,366,734,624,497 734,321,50,2358,366,535,768,696,548,341,470,806,2155,664,277,953,2605,624,200,1498,2280,774,497,865,602,1309,413,2235,148,993,691,2405,1508,1349,1436,183 0.5091440599781275,1.3008013122061457,3.107332731050088,-0.42111741427401633,1.1596174162013977,0.776099228012361,0.4702158680735321,0.5671569209643074,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.333399306791712,0.6055828069993638,1.4566081122737937,0.31242405485919195,-0.5099333245444402,0.6628536231131278,1.8084952079083476,-0.013711595274741894,-0.37712313988404206,0.4702158680735321,0.850660633843561,0.3917410017874763,0.7007922534137548,0.08978035873173802,1.0519984666463416,-0.3552276637336356,2.0981172248521958,0.29246072303462184,0.5863945968863824,-0.42111741427401633,-0.013711595274741894,0.06919953703395551,0.027862332156932304,1.9062125107768622 3643 Sphingolipid metabolism 14 29 3.13619783518909 0.0017115370547953 P51648,P27544,Q9NZJ7,P04062,P17900,P07602,P06280,Q8NBJ7,O95470,Q16739,Q16880,Q96G23,Q06136,Q9NRA0 Processes and pathways Reactome Pathways msigdb_reactome 32,5,492,449,516,231,549,44,209,282,246,55,347,257 1318,611,1879,1026,2035,209,449,549,1356,231,3508,2663,1886,516,2488,5,32,347,3358,282,246,44,55,2018,257,1130,3210,492,1785 0.06919953703395551,0.6818469365208409,-0.2252475557449799,0.25237072765834473,-0.28994201948861137,1.7095549611048153,0.9611422765478006,0.7573430676997512,0.04856032582182117,1.6261440706577892,-1.2146610216914933,-0.5323126699925248,-0.2252475557449799,0.8134720365945656,-0.465386116003162,4.73149126850177,3.476322734521235,1.2305331089305223,-0.9716940090710073,1.4566081122737937,1.592529825004484,3.204557850940264,2.980646976640566,-0.2683121372291175,1.5756684289722063,0.1918220918189678,-0.8065769270037231,0.8691865207095048,-0.16113177748554827 3643 Respiratory electron transport 31 64 3.1281250548100843 0.0017592531204302 Q7L592,O75438,P13073,O14949,P20674,O75380,Q8N8Q8,P21912,P03886,O75306,O96000,O95139,P47985,O95169,O43676,Q9Y6M9,P22695,O75489,Q9UDW1,O43674,O43819,O95168,P00403,O95167,O75880,O14548,Q8N183,O75251,O00217,P56556,Q86Y39 Processes and pathways Reactome Pathways msigdb_reactome 774,768,515,137,651,650,285,538,277,535,664,548,808,806,50,183,563,696,198,321,333,470,87,341,718,717,602,366,734,624,497 734,1875,717,137,321,50,2358,333,366,535,650,768,696,718,548,341,470,806,1515,2155,664,1885,87,277,953,1357,1583,1252,515,3334,1056,1218,3080,651,538,563,2605,1405,881,2607,1521,808,3129,624,1146,2625,1498,2280,774,497,865,602,285,1309,1683,1535,2235,993,1017,2405,1508,1349,198,183 0.5091440599781275,-0.2252475557449799,0.5285319592869173,2.1453820763492155,1.3008013122061457,3.107332731050088,-0.42111741427401633,1.2657472734377568,1.1596174162013977,0.776099228012361,0.6247218507870246,0.4702158680735321,0.5671569209643074,0.5285319592869173,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.6055828069993638,-0.2252475557449799,2.5138506890054337,1.4566081122737937,0.31242405485919195,0.04856032582182117,-0.0765234222627171,0.11030317972784781,0.8134720365945656,-0.947863266551478,0.23224335926748166,0.13076838476814698,-0.7369966820229626,0.6247218507870246,0.776099228012361,0.7385400373905193,-0.5099333245444402,0.027862332156932304,0.37199154172998977,-0.5099333245444402,-0.03458833609287247,0.4310823742970927,-0.7601130162085916,0.6628536231131278,0.17152746597699287,-0.5099333245444402,-0.013711595274741894,-0.37712313988404206,0.4702158680735321,0.850660633843561,0.3917410017874763,0.7007922534137548,1.4566081122737937,0.08978035873173802,-0.11870343366061006,-0.03458833609287247,-0.3552276637336356,0.29246072303462184,0.2724430641772754,-0.42111741427401633,-0.013711595274741894,0.06919953703395551,1.824865383027324,1.9062125107768622 3643 Calcium-binding protein 6 22 3.126246282313744 0.0017705320771321 Q9BRK5,Q02818,P80303,P43307,O43852,Q14257 Drugs and Diseases Pharos Drug Target Ontology pharos_dto 105,74,43,14,16,20 16,1930,539,2161,1520,14,2676,1452,43,74,20,203,3383,2833,786,2129,3021,1906,792,105,1965,3242 4.095354306912875,-0.24674747021415624,0.776099228012361,-0.333399306791712,-0.03458833609287247,4.1449986542955966,-0.5323126699925248,0.007105158915106008,3.2321311079528603,2.633054429019238,3.8042718536546554,1.792091065872174,-0.9956073764657654,-0.5998800653389513,0.4506749437853009,-0.3116375849262432,-0.6909922588809689,-0.2252475557449799,0.4506749437853009,2.3928800946790516,-0.24674747021415624,-0.829925724951396 3643 glycosyltransferase 16 31 3.1204603261619326 0.0018056861975648 O60512,Q9BT22,P04843,Q9H0U3,Q93063,P04844,Q8NAT1,Q8TCJ2,Q9BV10,Q9NYU2,Q10472,Q16739,Q9Y2G5,Q8N4A0,P46977,Q9P2E5 Functions Panther Protein class panther_protein_class 253,161,384,491,359,395,46,336,633,306,210,282,53,180,152,608 253,2801,2805,2951,384,395,1325,2364,1551,1030,1671,152,3544,1750,210,282,917,861,765,180,46,1422,336,359,631,161,633,491,306,608,53 1.5756684289722063,-0.5998800653389513,-0.5998800653389513,-0.6681029929832263,1.1239123190922105,1.105997161876891,0.06919953703395551,-0.42111741427401633,-0.055525473592154824,0.25237072765834473,-0.11870343366061006,2.06645172244257,-1.2892692909305767,-0.16113177748554827,1.7095549611048153,1.4566081122737937,0.3521891223123161,0.3917410017874763,0.4897054676751104,1.9062125107768622,3.190737263872994,0.027862332156932304,1.2657472734377568,1.1951570795527422,0.6628536231131278,2.018717139797755,0.6628536231131278,0.8691865207095048,1.3877470096535027,0.7007922534137548,3.0230894408053492 3643 Abnormal muscle fiber morphology 28 75 3.111209482621724 0.0018632271058514 P23786,P05067,Q99720,P50402,Q96RL7,P51114,P22626,Q9H2D1,O75648,P03886,P07196,P35637,Q9BUK6,O14979,P61978,O43676,Q9BTV4,Q8NI60,P51797,O95831,P12235,P11047,P00403,Q96RR1,Q13049,Q9Y4W6,Q70HW3,Q02809 Drugs and Diseases Human Phenotype Ontology msigdb_hp 255,385,656,396,532,408,527,286,536,277,291,418,45,425,679,50,311,446,191,195,581,580,87,603,598,620,357,613 1875,2905,425,50,2312,847,1290,2602,536,195,697,1885,87,1000,826,277,953,3533,385,1984,291,2991,1110,580,581,954,3246,527,255,1405,418,2492,1002,1671,396,1255,408,191,1491,2045,1221,2552,679,613,2223,598,2004,3055,3092,1119,834,1810,357,864,1756,1067,1564,2743,446,1961,1603,532,603,656,1906,311,45,286,843,1382,1436,2410,620,1479,973 -0.2252475557449799,-0.6452882514774274,1.0157859516403132,3.107332731050088,-0.39908622494449625,0.3917410017874763,0.08978035873173802,-0.5099333245444402,0.776099228012361,1.824865383027324,0.5671569209643074,-0.2252475557449799,2.5138506890054337,0.2724430641772754,0.4114378359281686,1.4566081122737937,0.31242405485919195,-1.2643087218937006,1.1239123190922105,-0.2683121372291175,1.4222538872246275,-0.6909922588809689,0.1918220918189678,0.71968985939333,0.71968985939333,0.31242405485919195,-0.8533532449353657,0.7948087934495096,1.5756684289722063,0.027862332156932304,1.0339137070490352,-0.465386116003162,0.2724430641772754,-0.11870343366061006,1.105997161876891,0.11030317972784781,1.0700404706148139,1.8412017569470738,-0.013711595274741894,-0.28994201948861137,0.13076838476814698,-0.48762464822389984,0.5863945968863824,0.6818469365208409,-0.3552276637336356,0.7007922534137548,-0.2683121372291175,-0.7139566269396745,-0.7369966820229626,0.1918220918189678,0.4114378359281686,-0.18244015934691968,1.1951570795527422,0.3917410017874763,-0.16113177748554827,0.23224335926748166,-0.055525473592154824,-0.5547632158192415,0.9794004819604001,-0.24674747021415624,-0.0765234222627171,0.7948087934495096,0.7007922534137548,0.6247218507870246,-0.2252475557449799,1.3356969350852728,3.204557850940264,1.4566081122737937,0.4114378359281686,0.04856032582182117,0.027862332156932304,-0.42111741427401633,0.6818469365208409,0.007105158915106008,0.31242405485919195 3643 Anion transport 42 84 3.109779119751306 0.001872272949932 Q15041,P45880,P0CG08,P30825,P11166,Q9Y277,O14745,Q9UBX3,Q9H2D1,Q8TB61,P53985,P14174,O43865,O43808,P21796,Q9C0H2,Q9Y619,Q14728,P08183,Q86VD7,P55011,Q6KCM7,O60831,Q9Y6M7,P51797,Q08722,P04920,P12235,Q02978,Q7L0J3,Q9UHG3,P41440,Q96S66,Q9HC21,Q9NZJ7,P07602,P30536,P04083,Q15042,P28288,Q01650,O00400 Processes and pathways GO Biological process msigdb_gobp 915,261,638,771,514,661,876,144,286,410,409,150,404,779,278,689,694,814,303,177,678,701,434,846,191,830,450,581,79,863,84,213,219,619,492,231,106,484,741,759,376,123 3216,123,876,2905,1176,1026,779,404,434,1733,1883,1580,484,450,1581,1445,231,303,1400,638,2852,514,581,904,150,278,759,106,771,2318,213,261,1942,191,2219,1491,409,1061,678,1187,2222,376,79,830,1638,814,915,741,1893,1301,1527,960,701,3439,1269,3504,863,177,1233,410,2180,2583,3566,219,1127,1014,689,2644,286,2141,1313,619,1103,3210,492,144,84,1434,661,2030,694,1287,3305,846 -0.829925724951396,2.239085653646518,0.37199154172998977,-0.6452882514774274,0.15117635458958095,0.25237072765834473,0.4506749437853009,1.0700404706148139,0.99761495810321,-0.16113177748554827,-0.2252475557449799,-0.0765234222627171,0.8691865207095048,0.9611422765478006,-0.0765234222627171,0.007105158915106008,1.6261440706577892,1.3877470096535027,0.027862332156932304,0.6438120248840904,-0.6225474635721432,0.8134720365945656,0.71968985939333,0.3521891223123161,2.06645172244257,1.4566081122737937,0.4897054676751104,2.377631431346862,0.4702158680735321,-0.39908622494449625,1.692943464578411,1.5418361654019872,-0.24674747021415624,1.8412017569470738,-0.3552276637336356,-0.013711595274741894,1.0700404706148139,0.23224335926748166,0.5863945968863824,0.15117635458958095,-0.3552276637336356,1.1417856605713883,2.5885562139486704,0.4114378359281686,-0.09758260109774661,0.4310823742970927,0.3521891223123161,0.5091440599781275,-0.2252475557449799,0.08978035873173802,-0.03458833609287247,0.31242405485919195,0.5671569209643074,-1.0678500734626066,0.11030317972784781,-1.1899723271023945,0.3917410017874763,1.9223823204371768,0.13076838476814698,1.0700404706148139,-0.333399306791712,-0.48762464822389984,-1.390041774081608,1.659614804060893,0.1918220918189678,0.2724430641772754,0.5863945968863824,-0.5099333245444402,1.4566081122737937,-0.3116375849262432,0.08978035873173802,0.6818469365208409,0.21206060116262693,-0.8065769270037231,0.8691865207095048,2.1296580535061174,2.5587558625495044,0.027862332156932304,0.6247218507870246,-0.2683121372291175,0.5863945968863824,0.11030317972784781,-0.900446979133231,0.4114378359281686 3643 Parkinsons disease 32 64 3.105576727806018 0.0018990834373342 P45880,O75438,P13073,O14949,Q9Y277,P20674,O75380,P21912,P14406,P21796,P03886,O75306,O96000,O95139,P47985,O43676,Q9Y6M9,P22695,O75489,Q9UDW1,O43674,P12235,O95168,P00403,O95167,O14548,P06576,P60604,P24539,O75251,O00217,P56556 Processes and pathways KEGG Pathways msigdb_kegg 261,768,515,137,661,651,650,538,28,278,277,535,664,548,808,50,183,563,696,198,321,581,470,87,341,717,92,739,362,366,734,624 734,1875,717,137,321,50,2358,366,535,650,768,696,1138,548,341,470,806,1515,2155,664,1885,87,1000,277,953,1581,92,1357,1583,1252,581,904,515,28,1056,1218,1932,3080,651,278,538,3246,563,362,1517,2605,1405,881,1141,261,808,3463,3129,624,739,2776,3050,1498,2280,3567,198,661,2080,183 0.5091440599781275,-0.2252475557449799,0.5285319592869173,2.1453820763492155,1.3008013122061457,3.107332731050088,-0.42111741427401633,1.1596174162013977,0.776099228012361,0.6247218507870246,0.4702158680735321,0.5671569209643074,0.17152746597699287,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.6055828069993638,-0.2252475557449799,2.5138506890054337,0.2724430641772754,1.4566081122737937,0.31242405485919195,-0.0765234222627171,2.4535901140386045,0.04856032582182117,-0.0765234222627171,0.11030317972784781,0.71968985939333,0.3521891223123161,0.8134720365945656,3.5429255537908872,0.23224335926748166,0.13076838476814698,-0.24674747021415624,-0.7369966820229626,0.6247218507870246,1.4566081122737937,0.776099228012361,-0.8533532449353657,0.7385400373905193,1.1774078138827289,-0.03458833609287247,-0.5099333245444402,0.027862332156932304,0.37199154172998977,0.17152746597699287,1.5418361654019872,0.4310823742970927,-1.1164377040450824,-0.7601130162085916,0.6628536231131278,0.5091440599781275,-0.5772854996002308,-0.7139566269396745,-0.013711595274741894,-0.37712313988404206,-1.390041774081608,1.824865383027324,0.6247218507870246,-0.28994201948861137,1.9062125107768622 3643 Electron transfer activity 32 61 3.102317852293815 0.0019201167091993 O75438,P13073,P20674,O75380,P30038,P21912,P14406,P03886,O75306,O96000,O95139,P47985,O43676,Q9Y6M9,O75489,Q9UDW1,O43674,P16435,O15460,O95168,P00403,O95167,Q13630,O14548,Q12797,P23378,O00217,O75251,P48163,P56556,Q7KZN9,P23368 Functions GO Molecular function msigdb_gomf 768,515,651,650,407,538,28,277,535,664,548,808,50,183,696,198,321,71,194,470,87,341,475,717,481,735,734,366,760,624,378,119 734,1875,717,194,1880,3121,321,50,2358,1693,366,535,650,768,696,548,341,470,806,1515,2155,664,2255,1885,87,277,953,1087,1357,1838,1252,3124,515,3334,28,3220,71,3080,651,538,119,735,2605,407,1405,881,2607,808,760,3129,624,481,475,2625,1498,2280,2741,378,1349,198,183 0.5091440599781275,-0.2252475557449799,0.5285319592869173,1.824865383027324,-0.2252475557449799,-0.7601130162085916,1.3008013122061457,3.107332731050088,-0.42111741427401633,-0.13988634815318823,1.1596174162013977,0.776099228012361,0.6247218507870246,0.4702158680735321,0.5671569209643074,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.6055828069993638,-0.37712313988404206,-0.2252475557449799,2.5138506890054337,1.4566081122737937,0.31242405485919195,0.21206060116262693,0.04856032582182117,-0.2038119362780547,0.11030317972784781,-0.7601130162085916,0.8134720365945656,-0.947863266551478,3.5429255537908872,-0.829925724951396,2.7213338218562386,-0.7369966820229626,0.6247218507870246,0.776099228012361,2.2700794880847806,0.5091440599781275,-0.5099333245444402,1.0700404706148139,0.027862332156932304,0.37199154172998977,-0.5099333245444402,0.4310823742970927,0.4897054676751104,-0.7601130162085916,0.6628536231131278,0.8876671508686171,0.9061027846832771,-0.5099333245444402,-0.013711595274741894,-0.37712313988404206,-0.5547632158192415,1.1417856605713883,0.06919953703395551,1.824865383027324,1.9062125107768622 3643 chaperone 24 80 3.078718994169223 0.0020789267228089 Q8IXB1,P30533,Q9NWM8,Q8NBS9,P27797,Q9Y680,O95456,P07237,Q15084,O15260,Q99543,P13667,Q9UHV9,O14657,O14967,Q9Y2R0,P78318,Q96JJ7,Q9Y2G8,Q96KC8,P30101,Q14554,P27824,Q7KZN9 Functions Panther Protein class panther_protein_class 129,132,8,402,539,39,165,41,419,52,571,443,456,577,469,86,88,350,354,228,352,108,118,378 733,3617,577,469,52,3348,1578,1694,1324,2806,165,2807,1836,41,443,2667,1404,539,118,352,2818,906,132,1587,1740,1631,3190,1454,1362,88,2680,2111,3050,1190,1595,2685,3136,1494,2567,108,1332,419,2506,2388,1369,2225,1528,2781,378,2127,129,602,2062,402,1763,920,3365,3292,1040,1683,350,228,2642,1713,571,2453,1427,3444,1343,1346,1245,1278,8,660,456,3241,354,86,1576,39 0.5091440599781275,-2.0288519737109936,0.71968985939333,0.9061027846832771,3.0230894408053492,-0.9716940090710073,-0.0765234222627171,-0.13988634815318823,0.06919953703395551,-0.5998800653389513,1.9706953778300438,-0.5998800653389513,-0.2038119362780547,3.2870083892475765,0.9794004819604001,-0.5323126699925248,0.027862332156932304,0.776099228012361,2.285531889164803,1.2128654372087189,-0.5998800653389513,0.3521891223123161,2.192370287416088,-0.0765234222627171,-0.16113177748554827,-0.09758260109774661,-0.8065769270037231,0.007105158915106008,0.04856032582182117,2.5138506890054337,-0.5323126699925248,-0.3116375849262432,-0.7139566269396745,0.15117635458958095,-0.0765234222627171,-0.5323126699925248,-0.7601130162085916,-0.013711595274741894,-0.48762464822389984,2.377631431346862,0.06919953703395551,1.0339137070490352,-0.465386116003162,-0.42111741427401633,0.04856032582182117,-0.3552276637336356,-0.03458833609287247,-0.5772854996002308,1.1417856605713883,-0.3116375849262432,2.223543950079106,0.7007922534137548,-0.28994201948861137,1.0880399570282553,-0.16113177748554827,0.3521891223123161,-0.9716940090710073,-0.900446979133231,0.25237072765834473,-0.11870343366061006,1.2305331089305223,1.64289728589414,-0.5099333245444402,-0.13988634815318823,0.7385400373905193,-0.44321720897869366,0.027862332156932304,-1.0678500734626066,0.06919953703395551,0.06919953703395551,0.13076838476814698,0.11030317972784781,4.352908051790398,0.6247218507870246,0.9611422765478006,-0.829925724951396,1.2128654372087189,2.5288465238651407,-0.055525473592154824,3.314313786509081 3643 Atpase coupled transmembrane transporter activity 10 29 3.0658168155737155 0.0021707626512552 O75027,Q9HD20,O15533,Q15388,P16615,O14678,Q9NUT2,P08183,P06576,P51797 Functions GO Molecular function msigdb_gomf 260,136,329,201,267,301,431,303,92,191 301,1176,329,260,976,1108,92,303,267,1553,2855,3310,1624,759,2318,1059,1588,191,2219,1222,1117,829,201,136,447,2074,431,1870,1512 1.3877470096535027,0.15117635458958095,1.2832942009953483,1.5418361654019872,0.29246072303462184,0.1918220918189678,2.4535901140386045,1.3877470096535027,1.5078566888617457,-0.055525473592154824,-0.6225474635721432,-0.9241144775154201,-0.09758260109774661,0.4897054676751104,-0.39908622494449625,0.23224335926748166,-0.0765234222627171,1.8412017569470738,-0.3552276637336356,0.13076838476814698,0.1918220918189678,0.4114378359281686,1.8084952079083476,2.1610753620574217,0.9794004819604001,-0.28994201948861137,1.0157859516403132,-0.2038119362780547,-0.013711595274741894 3643 EF-hand domain [IPR002048] 9 50 3.0639109287991397 0.0021846394365034 Q9Y680,Q9NWM8,Q9BRK5,Q02818,P80303,Q96AY3,O43852,Q14257,Q8NI22 Sequence InterPro Domain interpro_domain 39,8,105,74,43,75,16,20,22 778,16,2986,2602,1733,1028,2092,3159,1930,977,3605,324,3336,1292,2160,2161,1520,1630,1182,2676,43,74,3574,1300,20,3093,203,1096,701,1269,1760,1643,786,557,22,75,3021,1501,1906,105,1965,1776,1912,8,692,1721,971,1434,1831,39 0.4506749437853009,4.095354306912875,-0.6909922588809689,-0.5099333245444402,-0.16113177748554827,0.25237072765834473,-0.3116375849262432,-0.7833062289105431,-0.24674747021415624,0.29246072303462184,-1.808991775160554,1.3008013122061457,-0.947863266551478,0.08978035873173802,-0.333399306791712,-0.333399306791712,-0.03458833609287247,-0.09758260109774661,0.15117635458958095,-0.5323126699925248,3.2321311079528603,2.633054429019238,-1.4409977440294737,0.08978035873173802,3.8042718536546554,-0.7369966820229626,1.792091065872174,0.21206060116262693,0.5671569209643074,0.11030317972784781,-0.16113177748554827,-0.09758260109774661,0.4506749437853009,0.7573430676997512,3.7655729970606435,2.633054429019238,-0.6909922588809689,-0.013711595274741894,-0.2252475557449799,2.3928800946790516,-0.24674747021415624,-0.16113177748554827,-0.2252475557449799,4.352908051790398,0.5863945968863824,-0.13988634815318823,0.31242405485919195,0.027862332156932304,-0.18244015934691968,3.314313786509081 3643 Lysosomal lumen 21 37 3.0298992624863743 0.002446353199893 P17900,Q8NBS9,O14773,P08236,P10253,Q9BWS9,P04066,P34059,P06280,Q9UM22,P54802,Q14108,Q8IV08,Q9UMR5,P04062,P61916,P38435,Q9NZJ7,P07602,Q8NHP8,P50897 Localization GO Cellular component msigdb_gocc 516,402,25,157,537,40,426,551,549,51,436,444,65,66,449,466,80,492,231,233,244 1289,2415,25,1026,449,426,549,1356,231,3508,2361,157,537,2663,3509,880,3555,582,1886,516,551,80,3628,1671,244,436,466,3358,444,65,402,233,1466,40,492,51,66 0.08978035873173802,-0.44321720897869366,3.661517338984293,0.25237072765834473,0.9611422765478006,1.0157859516403132,0.7573430676997512,0.04856032582182117,1.6261440706577892,-1.2146610216914933,-0.42111741427401633,2.034660375542446,0.776099228012361,-0.5323126699925248,-1.2146610216914933,0.37199154172998977,-1.3394678563793248,0.71968985939333,-0.2252475557449799,0.8134720365945656,0.7573430676997512,2.5587558625495044,-2.314556559776012,-0.11870343366061006,1.592529825004484,0.99761495810321,0.9244936801618757,-0.9716940090710073,0.9794004819604001,2.808677111591547,1.0880399570282553,1.6261440706577892,0.007105158915106008,3.3006721207392853,0.8691865207095048,3.037189084386894,2.808677111591547 3643 Endoplasmic reticulum organization 23 50 3.020968641646446 0.0025196745353537 Q8NFQ8,Q8N4V1,Q00765,Q9H6H4,Q9P2W9,Q6NUK4,Q96A33,Q9BRK0,Q7L5D6,O14976,O14657,Q5JRA6,Q8N766,Q8N5M9,O95197,Q9NQC3,P61619,Q15629,Q12981,Q15042,P49257,P57088,Q9NPA0 Processes and pathways GO Biological process msigdb_gobp 647,274,681,312,58,186,188,189,585,320,577,342,349,353,223,365,363,112,367,741,238,625,391 1318,1249,577,320,755,2357,1026,1484,1696,223,2035,1631,238,1522,625,1453,363,681,982,367,1332,915,741,3169,112,833,342,2060,186,585,274,353,349,647,837,188,189,2018,2022,2401,3527,312,1825,391,365,2592,1130,2077,1785,58 0.06919953703395551,0.11030317972784781,0.71968985939333,1.3008013122061457,0.4897054676751104,-0.42111741427401633,0.25237072765834473,-0.013711595274741894,-0.13988634815318823,1.64289728589414,-0.28994201948861137,-0.09758260109774661,1.6093549777202447,-0.03458833609287247,0.6628536231131278,0.007105158915106008,1.1774078138827289,0.5863945968863824,0.29246072303462184,1.1596174162013977,0.06919953703395551,0.3521891223123161,0.5091440599781275,-0.7833062289105431,2.3470478270665613,0.4114378359281686,1.2481603149029503,-0.28994201948861137,1.8575044941143102,0.71968985939333,1.473728476771492,1.2128654372087189,1.2305331089305223,0.6438120248840904,0.4114378359281686,1.8575044941143102,1.8575044941143102,-0.2683121372291175,-0.2683121372291175,-0.42111741427401633,-1.239439561156638,1.3356969350852728,-0.18244015934691968,1.1239123190922105,1.1774078138827289,-0.48762464822389984,0.1918220918189678,-0.28994201948861137,-0.16113177748554827,2.9094252815894692 3643 Protein hydroxylation 10 17 3.0112937281350587 0.0026013707887742 Q12797,O75718,O15460,Q13162,P07237,Q96AY3,Q32P28,P13674,Q92791,Q96HE7 Processes and pathways GO Biological process msigdb_gobp 481,99,194,72,41,75,12,47,113,411 822,194,493,99,41,47,613,481,72,12,3099,113,75,411,1911,1777,3472 0.4114378359281686,1.824865383027324,0.850660633843561,2.423291779810149,3.2870083892475765,3.163027731650402,0.6818469365208409,0.8876671508686171,2.692012537294508,4.206660830311199,-0.7369966820229626,2.3470478270665613,2.633054429019238,1.0700404706148139,-0.2252475557449799,-0.16113177748554827,-1.1164377040450824 3643 Glycosyltransferase activity 25 56 3.0061612050911166 0.0026456869595983 O60512,P04843,P04844,Q16739,Q9H488,P46977,Q7Z4H8,Q9UGN5,Q9BT22,Q8NAT1,Q9NYU2,Q9Y2G5,Q8N4A0,P04062,O15294,Q8TCJ2,Q10472,Q6ZXV5,Q9P2E5,Q02809,Q93063,Q9BV10,Q96L58,Q16880,O60568 Functions GO Molecular function msigdb_gomf 253,384,395,282,674,152,283,30,161,46,306,53,180,449,328,336,210,214,608,613,359,633,631,246,493 822,328,662,253,493,2801,2602,2805,3280,2951,449,384,395,1325,1356,3508,2256,2851,3352,2364,954,1551,1057,2216,1060,1671,152,613,1009,1750,210,831,282,246,917,214,2126,283,765,180,46,919,336,359,2067,631,161,633,2345,674,1915,306,608,30,997,53 0.4114378359281686,1.2832942009953483,0.6055828069993638,1.5756684289722063,0.850660633843561,-0.5998800653389513,-0.5099333245444402,-0.5998800653389513,-0.900446979133231,-0.6681029929832263,0.9611422765478006,1.1239123190922105,1.105997161876891,0.06919953703395551,0.04856032582182117,-1.2146610216914933,-0.37712313988404206,-0.6225474635721432,-0.9716940090710073,-0.42111741427401633,0.31242405485919195,-0.055525473592154824,0.23224335926748166,-0.3552276637336356,0.23224335926748166,-0.11870343366061006,2.06645172244257,0.6818469365208409,0.2724430641772754,-0.16113177748554827,1.7095549611048153,0.4114378359281686,1.4566081122737937,1.592529825004484,0.3521891223123161,1.692943464578411,-0.3116375849262432,1.4566081122737937,0.4897054676751104,1.9062125107768622,3.190737263872994,0.3521891223123161,1.2657472734377568,1.1951570795527422,-0.28994201948861137,0.6628536231131278,2.018717139797755,0.6628536231131278,-0.39908622494449625,0.6055828069993638,-0.2252475557449799,1.3877470096535027,0.7007922534137548,3.489685011935334,0.29246072303462184,3.0230894408053492 3643 Glycosyltransferase 20 41 2.9944291465609285 0.0027495890882223 O60512,Q16739,Q9H488,P46977,Q7Z4H8,Q9UGN5,Q9BT22,Q8NAT1,Q9NYU2,Q9Y2G5,Q8N4A0,P04062,O15294,Q8TCJ2,Q10472,Q93063,Q9BV10,Q96L58,Q16880,O60568 Functions Protein Atlas Molecular function protein_atlas_molecular_function 253,282,674,152,283,30,161,46,306,53,180,449,328,336,210,359,633,631,246,493 328,662,253,493,2801,3280,2951,449,1325,2256,2851,3352,2364,954,1551,1057,2216,1060,152,1009,1750,210,831,282,246,917,283,765,180,46,919,336,359,631,161,633,2345,674,306,30,53 1.2832942009953483,0.6055828069993638,1.5756684289722063,0.850660633843561,-0.5998800653389513,-0.900446979133231,-0.6681029929832263,0.9611422765478006,0.06919953703395551,-0.37712313988404206,-0.6225474635721432,-0.9716940090710073,-0.42111741427401633,0.31242405485919195,-0.055525473592154824,0.23224335926748166,-0.3552276637336356,0.23224335926748166,2.06645172244257,0.2724430641772754,-0.16113177748554827,1.7095549611048153,0.4114378359281686,1.4566081122737937,1.592529825004484,0.3521891223123161,1.4566081122737937,0.4897054676751104,1.9062125107768622,3.190737263872994,0.3521891223123161,1.2657472734377568,1.1951570795527422,0.6628536231131278,2.018717139797755,0.6628536231131278,-0.39908622494449625,0.6055828069993638,1.3877470096535027,3.489685011935334,3.0230894408053492 3643 Signaling 6 21 2.985925142823494 0.0028272184133604 O15173,Q8WUJ1,Q7Z4V5,Q96GC9,O00264,Q96PC5 Drugs and Diseases Pharos Drug Target Ontology pharos_dto 37,10,239,208,236,154 236,823,37,2207,1112,1739,1060,1557,553,1636,3382,342,239,1567,10,208,1239,154,1467,1921,750 1.6093549777202447,0.4114378359281686,3.314313786509081,-0.3552276637336356,0.1918220918189678,-0.16113177748554827,0.23224335926748166,-0.055525473592154824,0.7573430676997512,-0.09758260109774661,-0.9956073764657654,1.2481603149029503,1.6093549777202447,-0.055525473592154824,4.231204838358074,1.7261314689431049,0.13076838476814698,2.06645172244257,0.007105158915106008,-0.2252475557449799,0.5091440599781275 3643 EF-hand domain pair [IPR011992] 9 55 2.982492350463783 0.0028591179318466 Q9Y680,Q9NWM8,Q9BRK5,Q02818,P80303,Q96AY3,O43852,Q14257,Q8NI22 Sequence InterPro Superfamily interpro_homologous_superfamily 39,8,105,74,43,75,16,20,22 778,16,2986,2602,1733,1028,2092,3159,1930,977,3605,324,3336,1292,2160,2161,1520,1630,1182,1556,2676,1452,43,74,3574,1300,20,3093,203,1096,701,1269,2833,1760,1643,786,2129,557,22,75,3021,1501,1906,105,1965,1776,1912,430,8,692,1721,971,1434,1831,39 0.4506749437853009,4.095354306912875,-0.6909922588809689,-0.5099333245444402,-0.16113177748554827,0.25237072765834473,-0.3116375849262432,-0.7833062289105431,-0.24674747021415624,0.29246072303462184,-1.808991775160554,1.3008013122061457,-0.947863266551478,0.08978035873173802,-0.333399306791712,-0.333399306791712,-0.03458833609287247,-0.09758260109774661,0.15117635458958095,-0.055525473592154824,-0.5323126699925248,0.007105158915106008,3.2321311079528603,2.633054429019238,-1.4409977440294737,0.08978035873173802,3.8042718536546554,-0.7369966820229626,1.792091065872174,0.21206060116262693,0.5671569209643074,0.11030317972784781,-0.5998800653389513,-0.16113177748554827,-0.09758260109774661,0.4506749437853009,-0.3116375849262432,0.7573430676997512,3.7655729970606435,2.633054429019238,-0.6909922588809689,-0.013711595274741894,-0.2252475557449799,2.3928800946790516,-0.24674747021415624,-0.16113177748554827,-0.2252475557449799,1.0157859516403132,4.352908051790398,0.5863945968863824,-0.13988634815318823,0.31242405485919195,0.027862332156932304,-0.18244015934691968,3.314313786509081 3643 Mitochondrial transport 30 95 2.982379791237577 0.0028601694402747 O60830,P23786,Q99595,Q9Y5J9,Q96EK5,P45880,P55786,O00165,P51572,Q9UBX3,Q8N8Q8,Q5JRX3,Q14849,Q9Y3D6,Q9Y5J7,Q9Y512,Q9Y584,Q8N4H5,Q3ZCQ8,Q9NS69,O95831,Q15070,Q15388,P12235,P06576,Q9GZY8,P30536,P24539,O75964,P49257 Processes and pathways GO Biological process msigdb_gobp 0,255,2,392,521,261,138,382,397,144,285,35,555,173,433,575,308,56,566,63,195,200,201,581,92,220,106,362,110,238 382,733,753,754,825,663,0,2419,1695,879,1138,110,1106,999,3331,849,3507,195,697,1000,1734,1581,92,2361,2604,2994,581,1932,2487,255,362,1517,2818,3188,106,3312,1141,2998,261,3463,2820,238,2044,1742,709,397,1257,138,1258,931,2776,1093,555,200,201,2624,3382,566,1896,35,1269,1680,1760,1643,56,285,965,521,3107,2746,2,866,2072,2526,220,795,1046,2074,63,1349,3212,144,1105,1434,609,1436,3541,173,575,308,751,433,392,1020,1174 1.1239123190922105,0.5091440599781275,0.4897054676751104,0.4897054676751104,0.4114378359281686,0.6055828069993638,5.89350676912575,-0.44321720897869366,-0.13988634815318823,0.37199154172998977,0.17152746597699287,2.3623540515125967,0.1918220918189678,0.2724430641772754,-0.947863266551478,0.3917410017874763,-1.2146610216914933,1.824865383027324,0.5671569209643074,0.2724430641772754,-0.16113177748554827,-0.0765234222627171,2.4535901140386045,-0.42111741427401633,-0.5099333245444402,-0.6909922588809689,0.71968985939333,-0.24674747021415624,-0.465386116003162,1.5756684289722063,1.1774078138827289,-0.03458833609287247,-0.5998800653389513,-0.8065769270037231,2.377631431346862,-0.9241144775154201,0.17152746597699287,-0.6909922588809689,1.5418361654019872,-1.1164377040450824,-0.5998800653389513,1.6093549777202447,-0.28994201948861137,-0.16113177748554827,0.5478694768628188,1.105997161876891,0.11030317972784781,2.1453820763492155,0.11030317972784781,0.33233340674752826,-0.5772854996002308,0.21206060116262693,0.7573430676997512,1.8084952079083476,1.8084952079083476,-0.5099333245444402,-0.9956073764657654,0.7385400373905193,-0.2252475557449799,3.4495350664729076,0.11030317972784781,-0.11870343366061006,-0.16113177748554827,-0.09758260109774661,2.9664513233824246,1.4566081122737937,0.31242405485919195,0.8134720365945656,-0.7369966820229626,-0.5547632158192415,5.347123193165582,0.3917410017874763,-0.28994201948861137,-0.465386116003162,1.659614804060893,0.4506749437853009,0.25237072765834473,-0.28994201948861137,2.837587540785622,0.06919953703395551,-0.8065769270037231,2.1296580535061174,0.21206060116262693,0.027862332156932304,0.7007922534137548,0.027862332156932304,-1.2643087218937006,1.9546235974626718,0.7385400373905193,1.3704358233118867,0.5091440599781275,1.0157859516403132,1.1239123190922105,0.2724430641772754,0.17152746597699287 3643 Copii coated er to golgi transport vesicle 18 41 2.9821707968085445 0.0028621227657525 Q9Y282,Q3ZAQ7,O95070,P05067,P30511,P49755,Q15437,O14653,Q9Y3A6,Q96RQ1,P04439,P10321,Q969X5,Q5BJH7,Q969M3,Q9BVK6,P49257,Q8NI22 Localization GO Cellular component msigdb_gocc 162,643,67,385,6,225,617,512,268,76,579,48,729,146,728,212,238,22 512,755,1834,2602,1179,1696,67,1619,3332,1139,579,385,48,6,238,225,979,2372,1034,1189,982,1299,3169,1707,617,643,146,3098,22,728,729,76,212,2022,995,971,162,268,1789,873,2082 0.8134720365945656,0.4897054676751104,-0.2038119362780547,-0.5099333245444402,0.15117635458958095,-0.13988634815318823,2.794183911350097,-0.09758260109774661,-0.947863266551478,0.17152746597699287,0.71968985939333,1.1239123190922105,3.135226461008061,4.673387267370069,1.6093549777202447,1.64289728589414,0.29246072303462184,-0.42111741427401633,0.25237072765834473,0.15117635458958095,0.29246072303462184,0.08978035873173802,-0.7833062289105431,-0.13988634815318823,0.6818469365208409,0.6438120248840904,2.0981172248521958,-0.7369966820229626,3.7655729970606435,0.5285319592869173,0.5285319592869173,2.6182485118089542,1.7095549611048153,-0.2683121372291175,0.29246072303462184,0.31242405485919195,2.0027419959879986,1.5078566888617457,-0.16113177748554827,0.3917410017874763,-0.28994201948861137 3643 Protein disulfide isomerase activity 9 11 2.980397049895112 0.002878749838477 P30101,Q15084,P30040,P07237,Q14554,Q92643,Q8NBS9,Q9BS26,Q96JJ7 Functions GO Molecular function msigdb_gomf 352,419,386,41,108,187,402,251,350 41,443,386,352,108,419,989,402,187,350,251 3.2870083892475765,0.9794004819604001,1.1239123190922105,1.2128654372087189,2.377631431346862,1.0339137070490352,0.29246072303462184,1.0880399570282553,1.8575044941143102,1.2305331089305223,1.592529825004484 3643 Nonalcoholic fatty liver disease 28 59 2.9773696010365147 0.0029073329004567 O75438,P13073,O14949,P20674,O75380,P54619,P21912,P14406,O75306,O96000,P31751,O95139,P47985,O43676,Q9Y6M9,P22695,O75489,Q9UDW1,O43674,Q96GC9,O95168,P00403,O95167,O14548,O75251,O00217,P56556,Q86Y39 Processes and pathways WikiPathways msigdb_wp 768,515,137,651,650,540,538,28,535,664,550,548,808,50,183,563,696,198,321,208,470,87,341,717,366,734,624,497 734,1875,717,2906,137,321,50,2358,366,535,650,768,696,548,341,470,806,1515,2155,664,1885,87,1355,1357,1583,1252,515,28,1056,1218,3080,651,538,563,2605,1405,2770,550,881,808,2550,3129,2044,1742,540,1062,624,2108,1998,3382,1498,2280,497,208,1342,2405,1349,198,183 0.5091440599781275,-0.2252475557449799,0.5285319592869173,-0.6452882514774274,2.1453820763492155,1.3008013122061457,3.107332731050088,-0.42111741427401633,1.1596174162013977,0.776099228012361,0.6247218507870246,0.4702158680735321,0.5671569209643074,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.6055828069993638,-0.2252475557449799,2.5138506890054337,0.04856032582182117,0.04856032582182117,-0.0765234222627171,0.11030317972784781,0.8134720365945656,3.5429255537908872,0.23224335926748166,0.13076838476814698,-0.7369966820229626,0.6247218507870246,0.776099228012361,0.7385400373905193,-0.5099333245444402,0.027862332156932304,-0.5772854996002308,0.7573430676997512,0.37199154172998977,0.4310823742970927,-0.48762464822389984,-0.7601130162085916,-0.28994201948861137,-0.16113177748554827,0.776099228012361,0.23224335926748166,0.6628536231131278,-0.3116375849262432,-0.2683121372291175,-0.9956073764657654,-0.013711595274741894,-0.37712313988404206,0.850660633843561,1.7261314689431049,0.06919953703395551,-0.42111741427401633,0.06919953703395551,1.824865383027324,1.9062125107768622 3643 Electron transport 31 57 2.976798263413812 0.0029127560389337 O43396,O75438,O14949,Q86YB8,O75380,Q96HE7,P21912,Q96CU9,P03886,O75306,O96000,Q9H3N1,O95139,O43169,P47985,O43676,Q9H1E5,Q9Y6M9,P22695,O75489,Q9UDW1,O43674,Q9Y241,Q6DKK2,O95168,P00403,O95167,O75251,O00217,P56556,Q86Y39 Processes and pathways Protein Atlas Biological process protein_atlas_biological_process 383,768,137,530,650,411,538,413,277,535,664,297,548,174,808,50,181,183,563,696,198,321,593,332,470,87,341,366,734,624,497 734,1875,137,174,383,321,50,2358,366,535,650,768,696,548,341,470,806,1515,2155,1180,664,1885,87,277,953,1357,3334,1056,3080,538,3081,563,2605,1405,881,3431,2607,808,3129,624,2625,1498,2280,2056,332,497,530,413,411,2890,181,297,2405,1349,198,593,183 0.5091440599781275,-0.2252475557449799,2.1453820763492155,1.9385192969684373,1.1239123190922105,1.3008013122061457,3.107332731050088,-0.42111741427401633,1.1596174162013977,0.776099228012361,0.6247218507870246,0.4702158680735321,0.5671569209643074,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.15117635458958095,0.6055828069993638,-0.2252475557449799,2.5138506890054337,1.4566081122737937,0.31242405485919195,0.04856032582182117,-0.947863266551478,0.23224335926748166,-0.7369966820229626,0.776099228012361,-0.7369966820229626,0.7385400373905193,-0.5099333245444402,0.027862332156932304,0.37199154172998977,-1.0678500734626066,-0.5099333245444402,0.4310823742970927,-0.7601130162085916,0.6628536231131278,-0.5099333245444402,-0.013711595274741894,-0.37712313988404206,-0.28994201948861137,1.2832942009953483,0.850660633843561,0.7948087934495096,1.0519984666463416,1.0700404706148139,-0.6225474635721432,1.9062125107768622,1.4050196301598754,-0.42111741427401633,0.06919953703395551,1.824865383027324,0.71968985939333,1.9062125107768622 3643 Oxidoreduction driven active transmembrane transporter activity 22 38 2.9758642337366794 0.0029216417393902 O75438,P13073,P20674,O75380,P03886,O75306,O96000,O95139,P47985,O43676,Q9Y6M9,O75489,Q9UDW1,O43674,O95168,P00403,O95167,O14548,O75251,O00217,P56556,Q7KZN9 Functions GO Molecular function msigdb_gomf 768,515,651,650,277,535,664,548,808,50,183,696,198,321,470,87,341,717,366,734,624,378 734,1875,717,321,50,2358,366,535,650,768,696,548,341,470,806,1515,2155,664,1885,87,277,953,1357,1252,515,3080,651,2605,881,808,3129,624,1498,2280,378,1349,198,183 0.5091440599781275,-0.2252475557449799,0.5285319592869173,1.3008013122061457,3.107332731050088,-0.42111741427401633,1.1596174162013977,0.776099228012361,0.6247218507870246,0.4702158680735321,0.5671569209643074,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.6055828069993638,-0.2252475557449799,2.5138506890054337,1.4566081122737937,0.31242405485919195,0.04856032582182117,0.11030317972784781,0.8134720365945656,-0.7369966820229626,0.6247218507870246,-0.5099333245444402,0.37199154172998977,0.4310823742970927,-0.7601130162085916,0.6628536231131278,-0.013711595274741894,-0.37712313988404206,1.1417856605713883,0.06919953703395551,1.824865383027324,1.9062125107768622 3643 Mitochondrial transmembrane transport 23 57 2.971642189578078 0.0029621167628175 P23786,O60830,Q99595,O75027,Q9NWR8,Q9H2D1,P21796,O43772,Q9Y619,Q9NUT2,Q3ZCQ8,O96008,Q9BSK2,O95831,Q15388,P50416,P12235,Q9H4I9,Q9UJZ1,P06576,Q9Y4W6,P24539,O75964 Processes and pathways GO Biological process msigdb_gobp 255,0,2,260,659,286,278,663,694,431,566,697,327,195,201,709,581,78,609,92,620,362,110 754,825,663,0,260,879,1733,1138,110,1106,1028,1580,195,697,1000,1581,92,2994,581,904,1932,278,255,362,1517,1141,3463,709,1491,1258,931,2222,201,566,725,786,1159,1961,965,3633,2583,2,1906,2072,1014,327,286,78,1313,1046,1314,431,659,1434,609,620,694 0.4897054676751104,0.4114378359281686,0.6055828069993638,5.89350676912575,1.5418361654019872,0.37199154172998977,-0.16113177748554827,0.17152746597699287,2.3623540515125967,0.1918220918189678,0.25237072765834473,-0.0765234222627171,1.824865383027324,0.5671569209643074,0.2724430641772754,-0.0765234222627171,2.4535901140386045,-0.6909922588809689,0.71968985939333,0.3521891223123161,-0.24674747021415624,1.4566081122737937,1.5756684289722063,1.1774078138827289,-0.03458833609287247,0.17152746597699287,-1.1164377040450824,0.5478694768628188,-0.013711595274741894,0.11030317972784781,0.33233340674752826,-0.3552276637336356,1.8084952079083476,0.7385400373905193,0.5285319592869173,0.4506749437853009,0.17152746597699287,-0.24674747021415624,0.31242405485919195,-3.0906760096205748,-0.48762464822389984,5.347123193165582,-0.2252475557449799,-0.28994201948861137,0.2724430641772754,1.3008013122061457,1.4566081122737937,2.6034158117050517,0.08978035873173802,0.25237072765834473,0.08978035873173802,1.0157859516403132,0.6247218507870246,0.027862332156932304,0.7007922534137548,0.6818469365208409,0.5863945968863824 3643 Intracellular protein transmembrane transport 10 26 2.9685090633443147 0.0029924827705101 O60830,Q99595,O95831,Q15388,P31751,P61619,O75298,Q15629,Q99442,Q9UGP8 Processes and pathways GO Biological process msigdb_gobp 0,2,195,201,550,363,546,112,467,221 754,825,0,546,1137,1106,195,697,2994,1217,550,1522,2611,2772,2496,363,3378,201,112,566,1307,1373,467,2,1046,221 0.4897054676751104,0.4114378359281686,5.89350676912575,0.7573430676997512,0.17152746597699287,0.1918220918189678,1.824865383027324,0.5671569209643074,-0.6909922588809689,0.13076838476814698,0.7573430676997512,-0.03458833609287247,-0.5099333245444402,-0.5772854996002308,-0.465386116003162,1.1774078138827289,-0.9956073764657654,1.8084952079083476,2.3470478270665613,0.7385400373905193,0.08978035873173802,0.04856032582182117,0.9244936801618757,5.347123193165582,0.25237072765834473,1.659614804060893 3643 Cytochrome complex assembly 11 16 2.9562503330397005 0.0031140423168534 Q9BSK2,Q15070,Q6DKK2,P53701,Q69YU5,O43819,Q7KZN9,Q8N8Q8,Q9Y2R0,O75880,P0DJ07 Processes and pathways GO Biological process msigdb_gobp 327,200,332,517,145,333,378,285,86,718,756 333,718,756,808,517,200,145,332,378,285,1683,1427,327,1245,1436,86 1.2657472734377568,0.5285319592869173,0.4897054676751104,0.4310823742970927,0.8134720365945656,1.8084952079083476,2.113903150898959,1.2832942009953483,1.1417856605713883,1.4566081122737937,-0.11870343366061006,0.027862332156932304,1.3008013122061457,0.13076838476814698,0.027862332156932304,2.5288465238651407 3643 Respiratory chain 24 42 2.9560577776070227 0.0031159871366712 O75438,O14949,O75380,Q96CU9,P03886,O75306,O96000,O95139,P47985,O43676,Q9Y6M9,P22695,O75489,Q9UDW1,O43674,Q9Y241,Q6DKK2,O95168,P00403,O95167,O75251,O00217,P56556,Q86Y39 Processes and pathways Protein Atlas Biological process protein_atlas_biological_process 768,137,650,413,277,535,664,548,808,50,183,563,696,198,321,593,332,470,87,341,366,734,624,497 734,1875,137,321,50,2358,366,535,650,768,696,548,341,470,806,1515,2155,664,1885,87,277,953,1357,1056,3080,563,2605,881,808,3129,624,1498,2280,332,497,413,2890,2405,1349,198,593,183 0.5091440599781275,-0.2252475557449799,2.1453820763492155,1.3008013122061457,3.107332731050088,-0.42111741427401633,1.1596174162013977,0.776099228012361,0.6247218507870246,0.4702158680735321,0.5671569209643074,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.6055828069993638,-0.2252475557449799,2.5138506890054337,1.4566081122737937,0.31242405485919195,0.04856032582182117,0.23224335926748166,-0.7369966820229626,0.7385400373905193,-0.5099333245444402,0.37199154172998977,0.4310823742970927,-0.7601130162085916,0.6628536231131278,-0.013711595274741894,-0.37712313988404206,1.2832942009953483,0.850660633843561,1.0519984666463416,-0.6225474635721432,-0.42111741427401633,0.06919953703395551,1.824865383027324,0.71968985939333,1.9062125107768622 3643 Antigen presentation folding assembly and peptide loading of class i mhc 9 19 2.954271301281648 0.0031340835068129 P30101,P30511,Q6P179,O15533,P51572,P10321,P27824,P27797,Q9NZ08 Processes and pathways Reactome Pathways msigdb_reactome 352,6,103,329,397,48,118,539,127 329,1696,1619,3332,1139,579,48,539,118,352,6,397,2372,1034,829,1707,103,127,873 1.2832942009953483,-0.13988634815318823,-0.09758260109774661,-0.947863266551478,0.17152746597699287,0.71968985939333,3.135226461008061,0.776099228012361,2.285531889164803,1.2128654372087189,4.673387267370069,1.105997161876891,-0.42111741427401633,0.25237072765834473,0.4114378359281686,-0.13988634815318823,2.3928800946790516,2.239085653646518,0.3917410017874763 3643 Sphingolipid biosynthetic process 11 20 2.9483877205034346 0.0031943615347913 O60512,P27544,P04062,Q9P035,Q6Y1H2,O95470,Q16739,Q16880,Q96G23,Q06136,Q9NRA0 Processes and pathways GO Biological process msigdb_gobp 253,5,449,340,529,209,282,246,55,347,257 611,1879,253,209,449,2488,5,3049,347,3358,282,246,1896,529,55,1165,257,1130,340,1785 0.6818469365208409,-0.2252475557449799,1.5756684289722063,1.7095549611048153,0.9611422765478006,-0.465386116003162,4.73149126850177,-0.7139566269396745,1.2305331089305223,-0.9716940090710073,1.4566081122737937,1.592529825004484,-0.2252475557449799,0.7948087934495096,2.980646976640566,0.17152746597699287,1.5756684289722063,0.1918220918189678,1.2657472734377568,-0.16113177748554827 3643 Protein targeting to mitochondrion 16 51 2.9358999388633373 0.0033258158283058 O60830,Q9Y5J9,Q99595,Q5JRX3,O95831,P55786,P51572,O00165,Q9Y3D6,Q15388,P30536,P49257,Q9Y584,Q8N4H5,Q9GZY8,Q9NS69 Processes and pathways GO Biological process msigdb_gobp 0,392,2,35,195,138,397,382,173,201,106,238,308,56,220,63 382,733,753,754,825,0,879,1106,999,3331,849,3507,195,697,2361,2994,2487,106,3312,238,2044,397,138,2776,1093,201,2624,566,1896,35,1680,56,2746,2,866,2526,220,795,1046,63,1349,3212,1105,3541,173,575,308,751,433,392,1020 1.1239123190922105,0.5091440599781275,0.4897054676751104,0.4897054676751104,0.4114378359281686,5.89350676912575,0.37199154172998977,0.1918220918189678,0.2724430641772754,-0.947863266551478,0.3917410017874763,-1.2146610216914933,1.824865383027324,0.5671569209643074,-0.42111741427401633,-0.6909922588809689,-0.465386116003162,2.377631431346862,-0.9241144775154201,1.6093549777202447,-0.28994201948861137,1.105997161876891,2.1453820763492155,-0.5772854996002308,0.21206060116262693,1.8084952079083476,-0.5099333245444402,0.7385400373905193,-0.2252475557449799,3.4495350664729076,-0.11870343366061006,2.9664513233824246,-0.5547632158192415,5.347123193165582,0.3917410017874763,-0.465386116003162,1.659614804060893,0.4506749437853009,0.25237072765834473,2.837587540785622,0.06919953703395551,-0.8065769270037231,0.21206060116262693,-1.2643087218937006,1.9546235974626718,0.7385400373905193,1.3704358233118867,0.5091440599781275,1.0157859516403132,1.1239123190922105,0.2724430641772754 3643 Udp glycosyltransferase activity 13 24 2.9243515183742863 0.0034517471080237 O60512,Q93063,O15294,O60568,Q8NAT1,Q9NYU2,Q10472,Q96L58,Q16739,Q8N4A0,Q9P2E5,Q16880,Q7Z4H8 Functions GO Molecular function msigdb_gomf 253,359,328,493,46,306,210,631,282,180,608,246,283 328,662,253,493,2805,1356,3508,954,1551,1057,1671,1750,210,282,246,283,765,180,46,919,359,631,306,608 1.2832942009953483,0.6055828069993638,1.5756684289722063,0.850660633843561,-0.5998800653389513,0.04856032582182117,-1.2146610216914933,0.31242405485919195,-0.055525473592154824,0.23224335926748166,-0.11870343366061006,-0.16113177748554827,1.7095549611048153,1.4566081122737937,1.592529825004484,1.4566081122737937,0.4897054676751104,1.9062125107768622,3.190737263872994,0.3521891223123161,1.1951570795527422,0.6628536231131278,1.3877470096535027,0.7007922534137548 3643 Intrinsic component of mitochondrial inner membrane 20 36 2.9126310233654795 0.0035839780990025 Q13505,O60830,Q99595,Q9NWR8,Q9NX63,Q8N8Q8,Q5XKP0,Q9UG56,Q9Y512,Q16891,Q15070,Q6P4A7,Q9H4I9,Q9H3K2,O43819,Q9Y2R0,O75880,Q9Y4W6,Q9HC21,P0DJ07 Localization GO Cellular component msigdb_gocc 519,0,2,659,544,285,670,159,575,700,200,725,78,468,333,86,718,620,619,756 754,333,0,1695,718,1580,756,2720,1184,2222,519,200,2625,700,1896,670,725,1010,285,1159,3633,2583,2,1966,468,78,1313,1101,619,1278,659,544,159,86,620,575 0.4897054676751104,1.2657472734377568,5.89350676912575,-0.13988634815318823,0.5285319592869173,-0.0765234222627171,0.4897054676751104,-0.5547632158192415,0.15117635458958095,-0.3552276637336356,0.8134720365945656,1.8084952079083476,-0.5099333245444402,0.5671569209643074,-0.2252475557449799,0.6055828069993638,0.5285319592869173,0.2724430641772754,1.4566081122737937,0.17152746597699287,-3.0906760096205748,-0.48762464822389984,5.347123193165582,-0.24674747021415624,0.9244936801618757,2.6034158117050517,0.08978035873173802,0.21206060116262693,0.6818469365208409,0.11030317972784781,0.6247218507870246,0.776099228012361,2.034660375542446,2.5288465238651407,0.6818469365208409,0.7385400373905193 3643 Antigen processing and presentation of peptide antigen 8 16 2.9104068275777077 0.0036095857109101 Q9UIQ6,P30101,P30511,Q6P179,O15533,P10321,P27797,Q9NZ08 Processes and pathways GO Biological process msigdb_gobp 230,352,6,103,329,48,539,127 2906,329,1139,579,48,1401,539,352,6,1255,829,103,1466,127,230,873 -0.6452882514774274,1.2832942009953483,0.17152746597699287,0.71968985939333,3.135226461008061,0.027862332156932304,0.776099228012361,1.2128654372087189,4.673387267370069,0.11030317972784781,0.4114378359281686,2.3928800946790516,0.007105158915106008,2.239085653646518,1.64289728589414,0.3917410017874763 3643 Nucleobase containing compound transmembrane transporter activity 10 18 2.8960627655604507 0.0037787681289678 Q9BSK2,Q9HC21,P51991,P12235,Q86VD7,P41440,Q8TB61,Q6KCM7,Q9H2D1,O00400 Functions GO Molecular function msigdb_gomf 327,619,738,581,177,213,410,701,286,123 1395,123,1176,779,1581,581,904,213,738,701,1269,177,1233,410,1127,327,286,619 0.027862332156932304,2.239085653646518,0.15117635458958095,0.4506749437853009,-0.0765234222627171,0.71968985939333,0.3521891223123161,1.692943464578411,0.5091440599781275,0.5671569209643074,0.11030317972784781,1.9223823204371768,0.13076838476814698,1.0700404706148139,0.1918220918189678,1.3008013122061457,1.4566081122737937,0.6818469365208409 3643 Liposaccharide metabolic process 14 22 2.893087526062845 0.0038147497596567 O60512,Q8NBX0,P04062,P17900,P04066,Q969N2,Q96S52,P06280,Q5H8A4,Q16739,Q16880,Q92643,Q9NWW5,O43292 Processes and pathways GO Biological process msigdb_gobp 253,33,449,516,426,586,234,549,207,282,246,187,252,373 373,253,2801,449,426,549,1356,3508,1886,516,3049,282,246,207,33,187,586,234,1165,252,3210,649 1.1417856605713883,1.5756684289722063,-0.5998800653389513,0.9611422765478006,1.0157859516403132,0.7573430676997512,0.04856032582182117,-1.2146610216914933,-0.2252475557449799,0.8134720365945656,-0.7139566269396745,1.4566081122737937,1.592529825004484,1.742673161727919,3.476322734521235,1.8575044941143102,0.71968985939333,1.6261440706577892,0.17152746597699287,1.592529825004484,-0.8065769270037231,0.6438120248840904 3643 Oxidoreductase activity acting on paired donors with incorporation or reduction of molecular oxygen 13 32 2.886688696970993 0.0038931921785896 Q6UW02,Q12797,O15460,P16435,P07237,Q15800,Q32P28,Q6PK18,P09601,P13674,O60568,P30519,P61457 Functions GO Molecular function msigdb_gomf 34,481,194,71,41,487,12,271,175,47,493,93,597 822,875,194,1178,493,706,805,1180,41,175,47,71,93,597,613,481,813,487,1095,12,3099,1956,271,34,2631,1530,936,3296,3274,3472,1172,1391 0.4114378359281686,0.37199154172998977,1.824865383027324,0.15117635458958095,0.850660633843561,0.5478694768628188,0.4310823742970927,0.15117635458958095,3.2870083892475765,1.9385192969684373,3.163027731650402,2.7213338218562386,2.4535901140386045,0.7007922534137548,0.6818469365208409,0.8876671508686171,0.4310823742970927,0.8691865207095048,0.21206060116262693,4.206660830311199,-0.7369966820229626,-0.24674747021415624,1.4908112708908634,3.4629394454457536,-0.5099333245444402,-0.03458833609287247,0.33233340674752826,-0.900446979133231,-0.8768601169890071,-1.1164377040450824,0.17152746597699287,0.04856032582182117 3643 Macromolecule transmembrane transporter activity 12 15 2.88185828463083 0.0039533749481666 O60830,O00189,Q99595,Q07820,P49755,P51991,Q15388,P61619,O96008,Q9Y584,Q9UGP8,Q9NS69 Functions GO Molecular function msigdb_gomf 0,695,2,553,225,738,201,363,697,308,221,63 695,754,0,1106,697,225,738,2611,363,553,201,2,63,221,308 0.5671569209643074,0.4897054676751104,5.89350676912575,0.1918220918189678,0.5671569209643074,1.64289728589414,0.5091440599781275,-0.5099333245444402,1.1774078138827289,0.7573430676997512,1.8084952079083476,5.347123193165582,2.837587540785622,1.659614804060893,1.3704358233118867 3643 Protein insertion into membrane 13 32 2.8792605336665384 0.0039860888716021 Q9Y5J9,Q15070,P61619,Q15629,Q9Y5J7,Q8N4V1,Q9Y512,Q9Y584,Q8N8Q8,Q96A33,Q8N766,Q9NPA0,Q9NS69 Processes and pathways GO Biological process msigdb_gobp 392,200,363,112,433,274,575,308,285,188,349,391,63 753,2357,1026,1484,1106,2361,3188,3312,1631,363,1332,200,112,1896,833,585,274,349,285,965,188,391,63,2077,1349,1436,575,308,751,433,392,1020 0.4897054676751104,-0.42111741427401633,0.25237072765834473,-0.013711595274741894,0.1918220918189678,-0.42111741427401633,-0.8065769270037231,-0.9241144775154201,-0.09758260109774661,1.1774078138827289,0.06919953703395551,1.8084952079083476,2.3470478270665613,-0.2252475557449799,0.4114378359281686,0.71968985939333,1.473728476771492,1.2305331089305223,1.4566081122737937,0.31242405485919195,1.8575044941143102,1.1239123190922105,2.837587540785622,-0.28994201948861137,0.06919953703395551,0.027862332156932304,0.7385400373905193,1.3704358233118867,0.5091440599781275,1.0157859516403132,1.1239123190922105,0.2724430641772754 3643 Protein exit from endoplasmic reticulum 9 26 2.876417622635329 0.004022171662199 Q8TCT9,P51572,Q9UBV2,P49257,Q9BVK6,O15260,P14625,Q9BUN8,Q13438 Processes and pathways GO Biological process msigdb_gobp 364,397,143,238,212,52,184,122,91 755,52,184,238,397,2552,1034,2772,739,91,1420,836,3505,364,1815,1817,1903,122,212,415,995,1078,143,2080,2472,873 0.4897054676751104,3.0230894408053492,1.8900097097013104,1.6093549777202447,1.105997161876891,-0.48762464822389984,0.25237072765834473,-0.5772854996002308,0.5091440599781275,2.483776090582276,0.027862332156932304,0.4114378359281686,-1.1899723271023945,1.1774078138827289,-0.18244015934691968,-0.18244015934691968,-0.2252475557449799,2.254597454452404,1.7095549611048153,1.0519984666463416,0.29246072303462184,0.23224335926748166,2.1296580535061174,-0.28994201948861137,-0.44321720897869366,0.3917410017874763 3643 Ceramide metabolic process 12 22 2.8722316753084045 0.0040758404272027 O60512,P27544,Q8NCC3,P04062,P17900,P06280,O95470,Q16739,Q16880,Q96G23,Q9NWW5,Q9NRA0 Processes and pathways GO Biological process msigdb_gobp 253,5,358,449,516,549,209,282,246,55,252,257 611,1879,253,209,449,549,1356,3508,516,5,2259,3049,3358,282,246,1896,358,55,1165,257,252,1130 0.6818469365208409,-0.2252475557449799,1.5756684289722063,1.7095549611048153,0.9611422765478006,0.7573430676997512,0.04856032582182117,-1.2146610216914933,0.8134720365945656,4.73149126850177,-0.37712313988404206,-0.7139566269396745,-0.9716940090710073,1.4566081122737937,1.592529825004484,-0.2252475557449799,1.1951570795527422,2.980646976640566,0.17152746597699287,1.5756684289722063,1.592529825004484,0.1918220918189678 3643 Wormian bones 6 18 2.869849756776987 0.0041066687707094 O75718,O95831,P07237,Q96AY3,Q32P28,O75844 Drugs and Diseases Human Phenotype Ontology msigdb_hp 99,195,41,75,12,217 822,99,217,195,826,41,3449,2667,1033,2559,263,2505,12,1334,1461,75,2789,502 0.4114378359281686,2.423291779810149,1.659614804060893,1.824865383027324,0.4114378359281686,3.2870083892475765,-1.092100830903645,-0.5323126699925248,0.25237072765834473,-0.48762464822389984,1.5418361654019872,-0.465386116003162,4.206660830311199,0.06919953703395551,0.007105158915106008,2.633054429019238,-0.5772854996002308,0.850660633843561 3643 Outer membrane 40 101 2.868863000882416 0.0041195018815411 Q13505,Q8IVP5,Q9HCL2,P45880,O00165,Q99720,Q9Y277,Q9Y6C9,P50402,Q96RL7,Q8N2A8,Q9NX63,Q5XKP0,P21796,Q07820,Q8WY22,Q99623,Q9Y3D6,Q9BUK6,O75323,O43169,P09601,Q9BVC6,Q9Y512,Q8N4H5,Q16891,Q9NS69,O96008,Q9NP58,Q8IWB1,Q15388,Q8WWV3,Q9GZY8,Q9NZ45,Q9UKU0,Q9NZJ7,P57105,P30536,O00264,Q96TC7 Localization GO Cellular component msigdb_gocc 519,645,3,261,382,656,661,266,396,532,19,544,670,278,553,36,167,173,45,547,174,175,305,575,56,700,63,697,447,68,201,460,220,229,96,492,232,106,236,380 382,236,1249,3640,174,847,3152,547,1695,1106,999,2480,697,1621,3486,2604,175,2852,2486,278,106,1887,2958,2720,1091,1521,261,396,709,1257,2675,232,3414,553,2618,519,1118,201,2624,3382,700,1896,1852,670,763,1854,1010,1155,645,68,1760,1643,963,19,56,1645,3141,2012,460,1603,36,2063,3455,2066,1041,532,380,1772,167,656,45,1966,305,1469,1568,2345,220,1915,3,447,2461,1973,1047,63,894,1472,1278,945,544,1130,229,492,3346,1280,2898,96,661,3541,173,575,266 1.1239123190922105,1.6093549777202447,0.11030317972784781,-4.459844000520055,1.9385192969684373,0.3917410017874763,-0.7833062289105431,0.7573430676997512,-0.13988634815318823,0.1918220918189678,0.2724430641772754,-0.465386116003162,0.5671569209643074,-0.09758260109774661,-1.1653727114302805,-0.5099333245444402,1.9385192969684373,-0.6225474635721432,-0.465386116003162,1.4566081122737937,2.377631431346862,-0.2252475557449799,-0.6681029929832263,-0.5547632158192415,0.21206060116262693,-0.03458833609287247,1.5418361654019872,1.105997161876891,0.5478694768628188,0.11030317972784781,-0.5323126699925248,1.6261440706577892,-1.0436847151728275,0.7573430676997512,-0.5099333245444402,0.8134720365945656,0.1918220918189678,1.8084952079083476,-0.5099333245444402,-0.9956073764657654,0.5671569209643074,-0.2252475557449799,-0.2038119362780547,0.6055828069993638,0.4897054676751104,-0.2038119362780547,0.2724430641772754,0.17152746597699287,0.6438120248840904,2.794183911350097,-0.16113177748554827,-0.09758260109774661,0.31242405485919195,3.906629108755367,2.9664513233824246,-0.09758260109774661,-0.7601130162085916,-0.2683121372291175,0.9428400929877672,-0.0765234222627171,3.355107227105292,-0.28994201948861137,-1.092100830903645,-0.28994201948861137,0.25237072765834473,0.7948087934495096,1.1417856605713883,-0.16113177748554827,1.9706953778300438,0.6247218507870246,3.204557850940264,-0.24674747021415624,1.3877470096535027,0.007105158915106008,-0.055525473592154824,-0.39908622494449625,1.659614804060893,-0.2252475557449799,5.227283322630259,0.9794004819604001,-0.44321720897869366,-0.24674747021415624,0.25237072765834473,2.837587540785622,0.37199154172998977,0.007105158915106008,0.11030317972784781,0.33233340674752826,0.776099228012361,0.1918220918189678,1.64289728589414,0.8691865207095048,-0.947863266551478,0.11030317972784781,-0.6225474635721432,2.4535901140386045,0.6247218507870246,-1.2643087218937006,1.9546235974626718,0.7385400373905193,1.5248649233353988 3643 Muscle abnormality related to mitochondrial dysfunction 22 42 2.856891309142215 0.0042781230764026 Q9UBX3,O75380,Q96CU9,P03886,O75648,O75306,O96000,Q9BUK6,O43676,Q9Y6M9,O75489,P12235,Q8IUX1,Q7LG56,Q9Y2R0,P00403,Q96RR1,Q8N183,O75251,O00217,P56556,Q86Y39 Drugs and Diseases Human Phenotype Ontology msigdb_hp 144,650,413,277,536,535,664,45,50,183,696,581,865,864,86,87,603,602,366,734,624,497 734,1875,50,847,366,535,650,696,536,664,1885,87,1000,277,953,581,3080,2605,1521,3129,2045,1221,624,1896,864,497,865,602,1309,1961,413,603,2235,45,1017,2405,1508,144,86,1923,1925,183 0.5091440599781275,-0.2252475557449799,3.107332731050088,0.3917410017874763,1.1596174162013977,0.776099228012361,0.6247218507870246,0.5671569209643074,0.776099228012361,0.6055828069993638,-0.2252475557449799,2.5138506890054337,0.2724430641772754,1.4566081122737937,0.31242405485919195,0.71968985939333,-0.7369966820229626,-0.5099333245444402,-0.03458833609287247,-0.7601130162085916,-0.28994201948861137,0.13076838476814698,0.6628536231131278,-0.2252475557449799,0.3917410017874763,0.850660633843561,0.3917410017874763,0.7007922534137548,0.08978035873173802,-0.24674747021415624,1.0519984666463416,0.7007922534137548,-0.3552276637336356,3.204557850940264,0.2724430641772754,-0.42111741427401633,-0.013711595274741894,2.1296580535061174,2.5288465238651407,-0.2252475557449799,-0.2252475557449799,1.9062125107768622 3643 Calnexin calreticulin cycle 9 10 2.8517228478661063 0.0043482995029737 P14314,P30101,Q9UKV5,Q9UBV2,Q9NYU2,P27824,Q13438,O60858,Q14697 Processes and pathways Reactome Pathways msigdb_reactome 324,352,169,143,306,118,91,60,445 60,324,539,118,352,91,445,306,143,169 2.866397368803325,1.3008013122061457,0.776099228012361,2.285531889164803,1.2128654372087189,2.483776090582276,0.9794004819604001,1.3877470096535027,2.1296580535061174,1.9706953778300438 3643 Protein transmembrane transporter activity 7 14 2.8499630615947567 0.0043724306746355 O60830,Q99595,P49755,Q15388,Q9Y584,Q9UGP8,Q9NS69 Functions GO Molecular function msigdb_gomf 0,2,225,201,308,221,63 695,754,0,1106,697,225,2611,363,553,201,2,63,221,308 0.5671569209643074,0.4897054676751104,5.89350676912575,0.1918220918189678,0.5671569209643074,1.64289728589414,-0.5099333245444402,1.1774078138827289,0.7573430676997512,1.8084952079083476,5.347123193165582,2.837587540785622,1.659614804060893,1.3704358233118867 3643 Organic anion transport 31 56 2.840658986046121 0.0045020425802539 Q15041,P30825,P11166,Q9UBX3,Q8TB61,P53985,Q9H2D1,P14174,O43808,Q9Y619,Q14728,Q86VD7,P55011,Q6KCM7,O60831,Q9Y6M7,P04920,Q08722,P12235,Q02978,Q7L0J3,P41440,Q9HC21,Q9NZJ7,P07602,P04083,Q15042,Q01650,P28288,O14745,O00400 Processes and pathways GO Biological process msigdb_gobp 915,771,514,144,410,409,286,150,779,694,814,177,678,701,434,846,450,830,581,79,863,213,619,492,231,484,741,376,759,876,123 123,876,2905,1176,779,434,1733,1883,1580,484,450,1581,1445,231,1400,2852,514,581,904,150,759,771,2318,213,1491,409,678,1187,376,79,830,814,915,741,1301,701,1269,3504,863,177,1233,410,2180,2583,3566,1127,1014,286,1313,619,3210,492,144,1434,694,846 2.239085653646518,0.37199154172998977,-0.6452882514774274,0.15117635458958095,0.4506749437853009,0.99761495810321,-0.16113177748554827,-0.2252475557449799,-0.0765234222627171,0.8691865207095048,0.9611422765478006,-0.0765234222627171,0.007105158915106008,1.6261440706577892,0.027862332156932304,-0.6225474635721432,0.8134720365945656,0.71968985939333,0.3521891223123161,2.06645172244257,0.4897054676751104,0.4702158680735321,-0.39908622494449625,1.692943464578411,-0.013711595274741894,1.0700404706148139,0.5863945968863824,0.15117635458958095,1.1417856605713883,2.5885562139486704,0.4114378359281686,0.4310823742970927,0.3521891223123161,0.5091440599781275,0.08978035873173802,0.5671569209643074,0.11030317972784781,-1.1899723271023945,0.3917410017874763,1.9223823204371768,0.13076838476814698,1.0700404706148139,-0.333399306791712,-0.48762464822389984,-1.390041774081608,0.1918220918189678,0.2724430641772754,1.4566081122737937,0.08978035873173802,0.6818469365208409,-0.8065769270037231,0.8691865207095048,2.1296580535061174,0.027862332156932304,0.5863945968863824,0.4114378359281686 3643 SLC superfamily of solute carriers 24 55 2.8349877881237213 0.0045827437410652 P11166,Q9Y6C9,Q9UBX3,Q8TB61,P53985,Q9H2D1,O43772,Q9Y619,Q8NEW0,Q86VD7,P55011,Q9BSK2,P04920,P12235,Q02978,P41440,Q96H78,Q9HC21,Q70HW3,Q9NZJ7,Q9H0U3,Q8N1S5,Q01650,O00400 Drugs and Diseases Pharos Drug Target Ontology pharos_dto 514,266,144,410,409,286,663,694,49,177,678,327,450,581,79,213,216,619,357,492,491,247,376,123 123,663,779,1733,1028,1580,450,1581,1400,514,581,904,771,213,1491,409,678,2222,376,79,1893,1301,701,3439,3513,1269,3504,357,863,177,1601,247,49,410,2179,216,2583,3566,1127,1014,327,491,286,941,1313,942,619,492,144,1434,2899,694,1287,266,846 2.239085653646518,0.6055828069993638,0.4506749437853009,-0.16113177748554827,0.25237072765834473,-0.0765234222627171,0.9611422765478006,-0.0765234222627171,0.027862332156932304,0.8134720365945656,0.71968985939333,0.3521891223123161,0.4702158680735321,1.692943464578411,-0.013711595274741894,1.0700404706148139,0.5863945968863824,-0.3552276637336356,1.1417856605713883,2.5885562139486704,-0.2252475557449799,0.08978035873173802,0.5671569209643074,-1.0678500734626066,-1.2146610216914933,0.11030317972784781,-1.1899723271023945,1.1951570795527422,0.3917410017874763,1.9223823204371768,-0.0765234222627171,1.592529825004484,3.12129119884825,1.0700404706148139,-0.333399306791712,1.6762968043598454,-0.48762464822389984,-1.390041774081608,0.1918220918189678,0.2724430641772754,1.3008013122061457,0.8691865207095048,1.4566081122737937,0.33233340674752826,0.08978035873173802,0.33233340674752826,0.6818469365208409,0.8691865207095048,2.1296580535061174,0.027862332156932304,-0.6225474635721432,0.5863945968863824,0.11030317972784781,1.5248649233353988,0.4114378359281686 3643 Mitochondrial complex iv assembly 9 16 2.834488473955311 0.0045899113640572 Q9Y241,P13073,Q8N8Q8,O43819,P20674,Q9Y2R0,Q7KZN9,P00403,P14406 Processes and pathways WikiPathways msigdb_wp 593,515,285,333,651,86,378,87,28 1875,333,1885,87,1583,756,1252,515,28,1218,651,378,285,1683,593,86 -0.2252475557449799,1.2657472734377568,-0.2252475557449799,2.5138506890054337,-0.0765234222627171,0.4897054676751104,0.11030317972784781,0.8134720365945656,3.5429255537908872,0.13076838476814698,0.6247218507870246,1.1417856605713883,1.4566081122737937,-0.11870343366061006,0.71968985939333,2.5288465238651407 3643 Atp synthesis coupled electron transport 24 44 2.833268413326006 0.0046074679895462 O75438,P13073,O14949,P20674,O75380,P03886,O75306,O96000,O95139,P47985,O43676,Q9Y6M9,O75489,Q9UDW1,O43674,Q9H3K2,O95168,P00403,O95167,O14548,O75251,O00217,P56556,Q7KZN9 Processes and pathways GO Biological process msigdb_gobp 768,515,137,651,650,277,535,664,548,808,50,183,696,198,321,468,470,87,341,717,366,734,624,378 734,1875,717,137,321,50,2358,366,535,650,768,696,548,341,470,806,1515,2155,664,1885,87,277,953,1251,1357,2363,1252,515,1056,1218,3080,651,2605,1405,808,3129,624,1498,2280,378,3567,468,198,183 0.5091440599781275,-0.2252475557449799,0.5285319592869173,2.1453820763492155,1.3008013122061457,3.107332731050088,-0.42111741427401633,1.1596174162013977,0.776099228012361,0.6247218507870246,0.4702158680735321,0.5671569209643074,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.6055828069993638,-0.2252475557449799,2.5138506890054337,1.4566081122737937,0.31242405485919195,0.11030317972784781,0.04856032582182117,-0.42111741427401633,0.11030317972784781,0.8134720365945656,0.23224335926748166,0.13076838476814698,-0.7369966820229626,0.6247218507870246,-0.5099333245444402,0.027862332156932304,0.4310823742970927,-0.7601130162085916,0.6628536231131278,-0.013711595274741894,-0.37712313988404206,1.1417856605713883,-1.390041774081608,0.9244936801618757,1.824865383027324,1.9062125107768622 3643 Cytochrome complex 10 19 2.8241154305725 0.0047411306520459 Q9UDW1,P13073,O14949,P47985,P20674,Q7KZN9,P00403,O14548,P14406,P22695 Localization GO Cellular component msigdb_gocc 198,515,137,808,651,378,87,717,28,563 1875,717,137,1885,87,1357,1583,1252,515,28,1056,1218,651,563,881,808,378,198,1436 -0.2252475557449799,0.5285319592869173,2.1453820763492155,-0.2252475557449799,2.5138506890054337,0.04856032582182117,-0.0765234222627171,0.11030317972784781,0.8134720365945656,3.5429255537908872,0.23224335926748166,0.13076838476814698,0.6247218507870246,0.7385400373905193,0.37199154172998977,0.4310823742970927,1.1417856605713883,1.824865383027324,0.027862332156932304 3643 Sarcoplasm 8 20 2.805511224007324 0.0050236831723855 Q12797,O00165,P16615,O43852,Q9BVC6,Q13555,P14625,P27797 Localization GO Cellular component msigdb_gocc 481,382,267,16,305,153,184,539 382,16,546,184,267,539,3311,2160,2216,1257,1525,1362,481,1365,153,1118,2287,1603,305,2592 1.1239123190922105,4.095354306912875,0.7573430676997512,1.8900097097013104,1.5078566888617457,0.776099228012361,-0.9241144775154201,-0.333399306791712,-0.3552276637336356,0.11030317972784781,-0.03458833609287247,0.04856032582182117,0.8876671508686171,0.04856032582182117,2.06645172244257,0.1918220918189678,-0.37712313988404206,-0.0765234222627171,1.3877470096535027,-0.48762464822389984 3643 External encapsulating structure organization 11 28 2.802657842247823 0.0050683408432827 O75718,P07942,P05067,Q13162,Q96AY3,P13674,Q92791,Q96HE7,P41440,O60568,P39210 Processes and pathways GO Biological process msigdb_gobp 99,196,385,72,75,47,113,411,213,493,505 493,2803,1290,99,1213,385,1445,196,580,47,1551,1840,505,213,909,72,3291,762,2340,2577,919,113,75,411,3143,1777,3066,2592 0.850660633843561,-0.5998800653389513,0.08978035873173802,2.423291779810149,0.13076838476814698,1.1239123190922105,0.007105158915106008,1.824865383027324,0.71968985939333,3.163027731650402,-0.055525473592154824,-0.2038119362780547,0.832089227524965,1.692943464578411,0.3521891223123161,2.692012537294508,-0.900446979133231,0.4897054676751104,-0.39908622494449625,-0.48762464822389984,0.3521891223123161,2.3470478270665613,2.633054429019238,1.0700404706148139,-0.7601130162085916,-0.16113177748554827,-0.7139566269396745,-0.48762464822389984 3643 Protein folding in endoplasmic reticulum 8 10 2.80251282465419 0.0050706200363175 Q8IXB1,P30101,Q13217,P07237,Q86YB8,Q96HE7,P27824,P14625 Processes and pathways GO Biological process msigdb_gobp 129,352,166,41,530,411,118,184 41,184,539,118,352,166,530,129,411,1785 3.2870083892475765,1.8900097097013104,0.776099228012361,2.285531889164803,1.2128654372087189,1.9706953778300438,0.7948087934495096,2.223543950079106,1.0700404706148139,-0.16113177748554827 3643 Carbohydrate derivative transport 13 23 2.79140815903877 0.0052479248445798 Q9HC21,Q8WTV0,Q9NZJ7,P07602,P12235,Q86VD7,P61916,P41440,Q8TB61,Q6KCM7,Q96AA3,O43808,O00400 Processes and pathways GO Biological process msigdb_gobp 619,420,492,231,581,177,466,213,410,701,250,779,123 1395,123,1176,779,1581,231,581,904,213,466,830,701,1269,177,1233,410,2180,420,250,1127,619,3210,492 0.027862332156932304,2.239085653646518,0.15117635458958095,0.4506749437853009,-0.0765234222627171,1.6261440706577892,0.71968985939333,0.3521891223123161,1.692943464578411,0.9244936801618757,0.4114378359281686,0.5671569209643074,0.11030317972784781,1.9223823204371768,0.13076838476814698,1.0700404706148139,-0.333399306791712,1.0339137070490352,1.592529825004484,0.1918220918189678,0.6818469365208409,-0.8065769270037231,0.8691865207095048 3643 Abnormal activity of mitochondrial respiratory chain 27 58 2.781312547922361 0.005413958651999 P13073,Q9UBX3,P20674,O75380,P30084,P21912,Q96CU9,P03886,O75648,O75306,O96000,O43676,Q9Y584,Q9Y6M9,Q3ZCQ8,O75489,P08559,Q9Y2R0,Q8N183,Q96EY7,Q70HW3,O75251,O00217,P56556,Q7KZN9,Q86Y39,Q9H0R6 Drugs and Diseases Human Phenotype Ontology msigdb_hp 515,144,651,650,528,538,413,277,536,535,664,50,308,183,566,696,451,86,602,747,357,366,734,624,378,497,510 734,1875,50,2358,366,535,650,696,536,2155,664,277,451,756,515,3080,651,538,2605,528,1405,1521,1939,3129,1328,2045,624,1892,3201,2280,566,834,2509,357,378,497,865,602,1309,1861,413,747,1240,2235,510,993,1017,2405,1508,1349,3302,144,897,86,1437,308,2536,183 0.5091440599781275,-0.2252475557449799,3.107332731050088,-0.42111741427401633,1.1596174162013977,0.776099228012361,0.6247218507870246,0.5671569209643074,0.776099228012361,-0.333399306791712,0.6055828069993638,1.4566081122737937,0.9611422765478006,0.4897054676751104,0.8134720365945656,-0.7369966820229626,0.6247218507870246,0.776099228012361,-0.5099333245444402,0.7948087934495096,0.027862332156932304,-0.03458833609287247,-0.24674747021415624,-0.7601130162085916,0.06919953703395551,-0.28994201948861137,0.6628536231131278,-0.2252475557449799,-0.8065769270037231,-0.37712313988404206,0.7385400373905193,0.4114378359281686,-0.465386116003162,1.1951570795527422,1.1417856605713883,0.850660633843561,0.3917410017874763,0.7007922534137548,0.08978035873173802,-0.2038119362780547,1.0519984666463416,0.5091440599781275,0.13076838476814698,-0.3552276637336356,0.832089227524965,0.29246072303462184,0.2724430641772754,-0.42111741427401633,-0.013711595274741894,0.06919953703395551,-0.900446979133231,2.1296580535061174,0.37199154172998977,2.5288465238651407,0.027862332156932304,1.3704358233118867,-0.465386116003162,1.9062125107768622 3643 oxidoreductase 24 50 2.7790396945763063 0.0054519862350057 Q15067,O43396,O14949,Q86YB8,O75380,Q96HE7,O75306,O43169,O15254,O43676,Q9Y6M9,Q9Y320,Q9BUP3,O95831,O43674,P16435,Q9Y6N5,O95168,P00403,Q13630,Q8N0U8,P56556,Q86Y39,P23368 Functions Panther Protein class panther_protein_class 387,383,137,530,650,411,535,174,302,50,183,448,590,195,321,71,205,470,87,475,498,624,497,119 734,1875,137,302,174,383,321,50,2358,535,650,470,806,1515,195,664,87,953,2662,2363,3334,71,3081,119,2915,3431,2607,760,3129,624,1749,475,387,2625,1498,2280,2927,1231,497,530,498,1158,411,3258,590,2347,2405,448,183,205 0.5091440599781275,-0.2252475557449799,2.1453820763492155,1.3877470096535027,1.9385192969684373,1.1239123190922105,1.3008013122061457,3.107332731050088,-0.42111741427401633,0.776099228012361,0.6247218507870246,0.9061027846832771,0.4310823742970927,-0.03458833609287247,1.824865383027324,0.6055828069993638,2.5138506890054337,0.31242405485919195,-0.5323126699925248,-0.42111741427401633,-0.947863266551478,2.7213338218562386,-0.7369966820229626,2.2700794880847806,-0.6452882514774274,-1.0678500734626066,-0.5099333245444402,0.4897054676751104,-0.7601130162085916,0.6628536231131278,-0.16113177748554827,0.9061027846832771,1.1239123190922105,-0.5099333245444402,-0.013711595274741894,-0.37712313988404206,-0.6452882514774274,0.13076838476814698,0.850660633843561,0.7948087934495096,0.850660633843561,0.17152746597699287,1.0700404706148139,-0.8533532449353657,0.71968985939333,-0.39908622494449625,-0.42111741427401633,0.9794004819604001,1.9062125107768622,1.7756527899161132 3643 Oxidoreductase activity acting on a sulfur group of donors 16 30 2.771540645554765 0.0055791706451919 Q8IXB1,Q9Y320,P30101,Q15084,O43396,P07237,Q9H3N1,Q14554,Q9Y6N5,O95881,O43819,Q9UHG3,Q96HE7,Q8NBM8,P13667,Q96JJ7 Functions GO Molecular function msigdb_gomf 129,448,352,419,383,41,297,108,205,237,333,84,411,248,443,350 383,333,3485,237,2255,3351,41,2363,443,1058,352,3431,3417,3599,108,419,2056,1231,989,3440,530,129,248,411,350,1606,297,84,448,205 1.1239123190922105,1.2657472734377568,-1.1653727114302805,1.6093549777202447,-0.37712313988404206,-0.9716940090710073,3.2870083892475765,-0.42111741427401633,0.9794004819604001,0.23224335926748166,1.2128654372087189,-1.0678500734626066,-1.0436847151728275,-1.7284029204584987,2.377631431346862,1.0339137070490352,-0.28994201948861137,0.13076838476814698,0.29246072303462184,-1.0678500734626066,0.7948087934495096,2.223543950079106,1.592529825004484,1.0700404706148139,1.2305331089305223,-0.0765234222627171,1.4050196301598754,2.5587558625495044,0.9794004819604001,1.7756527899161132 3643 Protein n linked glycosylation 11 23 2.7701678264193275 0.0056027415767876 Q9BT22,Q13724,P04843,Q9H0U3,Q93063,P04844,Q8TCJ2,Q9NYU2,P46977,Q96AA3,Q86YN1 Processes and pathways GO Biological process msigdb_gobp 161,356,384,491,359,395,336,306,152,250,155 2602,848,902,384,395,1551,1057,1030,152,3544,2223,356,486,155,336,359,250,161,633,491,942,306,2080 -0.5099333245444402,0.3917410017874763,0.3521891223123161,1.1239123190922105,1.105997161876891,-0.055525473592154824,0.23224335926748166,0.25237072765834473,2.06645172244257,-1.2892692909305767,-0.3552276637336356,1.1951570795527422,0.8691865207095048,2.050571853401436,1.2657472734377568,1.1951570795527422,1.592529825004484,2.018717139797755,0.6628536231131278,0.8691865207095048,0.33233340674752826,1.3877470096535027,-0.28994201948861137 3643 Peptide hormone metabolism 6 18 2.759761239337521 0.00578436191523 O00471,P67812,Q15005,Q8NEW0,Q96HE7,O75787 Processes and pathways Reactome Pathways msigdb_reactome 351,128,269,49,411,254 351,1618,254,3128,1181,1627,1407,128,269,530,2577,49,838,1766,411,1768,1539,1476 1.2128654372087189,-0.09758260109774661,1.5756684289722063,-0.7601130162085916,0.15117635458958095,-0.09758260109774661,0.027862332156932304,2.223543950079106,1.4908112708908634,0.7948087934495096,-0.48762464822389984,3.12129119884825,0.4114378359281686,-0.16113177748554827,1.0700404706148139,-0.16113177748554827,-0.03458833609287247,0.007105158915106008 3643 Protein o linked glycosylation 13 18 2.7569565415868165 0.0058342104940807 O43505,Q02809,O15294,Q9H488,Q8NAT1,Q86SF2,Q10472,Q9Y2G5,Q6ZXV5,Q8N4A0,O60568,Q7Z4H8,Q9H9S5 Processes and pathways GO Biological process msigdb_gobp 662,613,328,674,46,765,210,53,214,180,493,283,843 822,328,662,2909,493,2801,902,613,1750,210,214,283,765,180,46,674,843,53 0.4114378359281686,1.2832942009953483,0.6055828069993638,-0.6452882514774274,0.850660633843561,-0.5998800653389513,0.3521891223123161,0.6818469365208409,-0.16113177748554827,1.7095549611048153,1.692943464578411,1.4566081122737937,0.4897054676751104,1.9062125107768622,3.190737263872994,0.6055828069993638,0.4114378359281686,3.0230894408053492 3643 Type i collagen synthesis in the context of osteogenesis imperfecta 6 13 2.754417916297087 0.005879663654531 O75718,O15460,P07237,Q96AY3,Q32P28,P13674 Processes and pathways WikiPathways msigdb_wp 99,194,41,75,12,47 822,194,99,41,47,2667,909,613,12,342,919,75,2592 0.4114378359281686,1.824865383027324,2.423291779810149,3.2870083892475765,3.163027731650402,-0.5323126699925248,0.3521891223123161,0.6818469365208409,4.206660830311199,1.2481603149029503,0.3521891223123161,2.633054429019238,-0.48762464822389984 3643 Protease 27 89 2.753910838419612 0.0058887808533096 P67812,P55786,Q9BYT8,Q15005,Q7Z2K6,O14773,Q96RU2,Q5JRX3,Q9NQW7,Q16740,Q9H8M7,Q9UPT9,P28072,Q2T9J0,Q92643,P52888,Q4J6C6,Q92905,Q9H3G5,O75844,Q9UIQ6,P78536,Q6P179,Q8TCT9,P28074,Q99436,Q9NZ08 Functions Protein Atlas Molecular function protein_atlas_molecular_function 128,138,141,269,147,25,288,35,38,428,430,307,54,309,187,325,459,77,344,217,230,226,103,364,243,381,127 899,900,25,2246,578,879,217,3530,2989,2990,1442,3159,1663,2663,2483,1401,3336,54,243,3430,3474,1519,1628,3587,955,2493,2263,2551,1803,325,2326,854,979,3004,138,1407,128,226,3288,1330,3398,2441,269,428,309,459,35,723,103,147,1563,2448,1307,3017,1762,364,187,77,2970,1533,731,3256,655,938,288,841,381,3567,1466,866,141,795,344,3614,3324,430,464,591,38,869,2024,127,230,307,1248,1133,2412,620,3243 0.3521891223123161,0.3521891223123161,3.661517338984293,-0.37712313988404206,0.71968985939333,0.37199154172998977,1.659614804060893,-1.2643087218937006,-0.6909922588809689,-0.6909922588809689,0.007105158915106008,-0.7833062289105431,-0.11870343366061006,-0.5323126699925248,-0.465386116003162,0.027862332156932304,-0.947863266551478,2.980646976640566,1.592529825004484,-1.0678500734626066,-1.1408614189622066,-0.03458833609287247,-0.09758260109774661,-1.5701048558026782,0.31242405485919195,-0.465386116003162,-0.37712313988404206,-0.48762464822389984,-0.18244015934691968,1.3008013122061457,-0.39908622494449625,0.3917410017874763,0.29246072303462184,-0.6909922588809689,2.1453820763492155,0.027862332156932304,2.223543950079106,1.64289728589414,-0.900446979133231,0.06919953703395551,-1.019604048841438,-0.44321720897869366,1.4908112708908634,1.0157859516403132,1.3530858670526362,0.9428400929877672,3.4495350664729076,0.5285319592869173,2.3928800946790516,2.0981172248521958,-0.055525473592154824,-0.44321720897869366,0.08978035873173802,-0.6909922588809689,-0.16113177748554827,1.1774078138827289,1.8575044941143102,2.6034158117050517,-0.6681029929832263,-0.03458833609287247,0.5285319592869173,-0.8533532449353657,0.6247218507870246,0.33233340674752826,1.4394499815716364,0.4114378359281686,1.1417856605713883,-1.390041774081608,0.007105158915106008,0.3917410017874763,2.1296580535061174,0.4506749437853009,1.2481603149029503,-1.9455372097525145,-0.9241144775154201,1.0157859516403132,0.9428400929877672,0.71968985939333,3.314313786509081,0.3917410017874763,-0.2683121372291175,2.239085653646518,1.64289728589414,1.3877470096535027,0.13076838476814698,0.1918220918189678,-0.42111741427401633,0.6818469365208409,-0.829925724951396 3643 Chaperone J-domain superfamily [IPR036869] 7 20 2.7443543979829346 0.0060630043819309 Q8IXB1,Q9Y2G8,Q96KC8,O14976,Q13217,Q99543,Q9UGP8 Sequence InterPro Superfamily interpro_homologous_superfamily 129,354,228,320,166,571,221 320,1578,1694,1290,1324,1404,1587,166,2225,129,920,1040,228,571,2453,1278,1315,660,221,354 1.3008013122061457,-0.0765234222627171,-0.13988634815318823,0.08978035873173802,0.06919953703395551,0.027862332156932304,-0.0765234222627171,1.9706953778300438,-0.3552276637336356,2.223543950079106,0.3521891223123161,0.25237072765834473,1.64289728589414,0.7385400373905193,-0.44321720897869366,0.11030317972784781,0.08978035873173802,0.6247218507870246,1.659614804060893,1.2128654372087189 3643 DnaJ domain [IPR001623] 7 20 2.7443543979829346 0.0060630043819309 Q8IXB1,Q9Y2G8,Q96KC8,O14976,Q13217,Q99543,Q9UGP8 Sequence InterPro Domain interpro_domain 129,354,228,320,166,571,221 320,1578,1694,1290,1324,1404,1587,166,2225,129,920,1040,228,571,2453,1278,1315,660,221,354 1.3008013122061457,-0.0765234222627171,-0.13988634815318823,0.08978035873173802,0.06919953703395551,0.027862332156932304,-0.0765234222627171,1.9706953778300438,-0.3552276637336356,2.223543950079106,0.3521891223123161,0.25237072765834473,1.64289728589414,0.7385400373905193,-0.44321720897869366,0.11030317972784781,0.08978035873173802,0.6247218507870246,1.659614804060893,1.2128654372087189 3643 Nadh dehydrogenase activity 16 28 2.742209696906572 0.0061027367894668 O75489,O96000,O95831,O43674,O75438,O95139,O75251,O00217,O43676,O75380,Q9Y6M9,O95168,P56556,O95167,P03886,O75306 Functions GO Molecular function msigdb_gomf 696,664,195,321,768,548,366,734,50,650,183,470,624,341,277,535 734,1875,321,50,2358,366,535,650,768,696,548,341,470,806,1515,2155,195,664,277,953,3080,2605,3129,624,1498,2280,1349,183 0.5091440599781275,-0.2252475557449799,1.3008013122061457,3.107332731050088,-0.42111741427401633,1.1596174162013977,0.776099228012361,0.6247218507870246,0.4702158680735321,0.5671569209643074,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,1.824865383027324,0.6055828069993638,1.4566081122737937,0.31242405485919195,-0.7369966820229626,-0.5099333245444402,-0.7601130162085916,0.6628536231131278,-0.013711595274741894,-0.37712313988404206,0.06919953703395551,1.9062125107768622 3643 Antigen processing and presentation of peptide antigen via mhc class i 8 14 2.734611152906899 0.0062454005281198 Q9UIQ6,P30101,P30511,Q6P179,O15533,P10321,P27797,Q9NZ08 Processes and pathways GO Biological process msigdb_gobp 230,352,6,103,329,48,539,127 2906,329,1139,579,48,1401,539,352,6,829,103,127,230,873 -0.6452882514774274,1.2832942009953483,0.17152746597699287,0.71968985939333,3.135226461008061,0.027862332156932304,0.776099228012361,1.2128654372087189,4.673387267370069,0.4114378359281686,2.3928800946790516,2.239085653646518,1.64289728589414,0.3917410017874763 3643 metalloprotease 12 27 2.731492527117404 0.0063048170789281 Q9UIQ6,Q9NQH7,Q5JRX3,P52888,Q6P179,P55786,Q9BYT8,O43847,Q7Z2K6,O75844,Q9NZ08,P22695 Functions Panther Protein class panther_protein_class 230,591,35,325,103,138,141,578,147,217,127,563 578,879,217,1442,3606,2483,1401,563,3430,881,955,325,854,138,1093,35,103,147,938,841,866,141,591,2024,127,230,620 0.71968985939333,0.37199154172998977,1.659614804060893,0.007105158915106008,-1.8360748989715658,-0.465386116003162,0.027862332156932304,0.7385400373905193,-1.0678500734626066,0.37199154172998977,0.31242405485919195,1.3008013122061457,0.3917410017874763,2.1453820763492155,0.21206060116262693,3.4495350664729076,2.3928800946790516,2.0981172248521958,0.33233340674752826,0.4114378359281686,0.3917410017874763,2.1296580535061174,0.71968985939333,-0.2683121372291175,2.239085653646518,1.64289728589414,0.6818469365208409 3643 Nucleotide transport 11 18 2.731080925912951 0.0063126968593005 Q9BSK2,Q9HC21,Q08722,P12235,Q86VD7,P41440,Q8TB61,Q6KCM7,Q9H2D1,O43808,O00400 Processes and pathways GO Biological process msigdb_gobp 327,619,830,581,177,213,410,701,286,779,123 123,1176,779,1581,581,904,213,830,701,1269,177,1233,410,2180,1127,327,286,619 2.239085653646518,0.15117635458958095,0.4506749437853009,-0.0765234222627171,0.71968985939333,0.3521891223123161,1.692943464578411,0.4114378359281686,0.5671569209643074,0.11030317972784781,1.9223823204371768,0.13076838476814698,1.0700404706148139,-0.333399306791712,0.1918220918189678,1.3008013122061457,1.4566081122737937,0.6818469365208409 3643 Ubiquitin dependent erad pathway 14 41 2.730570321363603 0.0063224842983971 Q8IXB1,O75477,Q9UKV5,P51572,Q8TCJ2,Q9UBV2,Q9UBU6,Q96A33,O94905,P27824,P14625,Q9BUN8,Q13438,O60858 Processes and pathways GO Biological process msigdb_gobp 129,322,169,397,336,143,82,188,334,118,184,122,91,60 469,1484,60,322,780,334,2990,707,184,539,118,1736,1631,397,3004,2552,2772,739,3089,91,1227,2278,3098,1193,129,3505,336,1764,1817,188,1903,122,1315,82,143,169,799,2651,3304,2080,2472 0.9061027846832771,-0.013711595274741894,2.866397368803325,1.3008013122061457,0.4506749437853009,1.2657472734377568,-0.6909922588809689,0.5478694768628188,1.8900097097013104,0.776099228012361,2.285531889164803,-0.16113177748554827,-0.09758260109774661,1.105997161876891,-0.6909922588809689,-0.48762464822389984,-0.5772854996002308,0.5091440599781275,-0.7369966820229626,2.483776090582276,0.13076838476814698,-0.37712313988404206,-0.7369966820229626,0.15117635458958095,2.223543950079106,-1.1899723271023945,1.2657472734377568,-0.16113177748554827,-0.18244015934691968,1.8575044941143102,-0.2252475557449799,2.254597454452404,0.08978035873173802,2.5587558625495044,2.1296580535061174,1.9706953778300438,0.4506749437853009,-0.5099333245444402,-0.900446979133231,-0.28994201948861137,-0.44321720897869366 3643 Erad pathway 16 49 2.730048994225764 0.0063324913605111 Q8IXB1,O75477,Q9UKV5,Q8TCT9,Q13438,Q8TCJ2,Q9UBV2,Q9UBU6,Q9NYU2,Q96A33,O94905,P27824,P14625,Q9BUN8,Q4ZIN3,O60858 Processes and pathways GO Biological process msigdb_gobp 129,322,169,364,91,336,143,82,306,188,334,118,184,122,27,60 3617,469,1484,60,322,780,334,2990,707,184,539,118,1736,1631,397,3004,2552,2772,739,3089,1224,91,1227,2278,27,3098,1193,585,129,836,3505,336,364,1764,1817,188,1903,122,3178,1315,306,82,143,169,799,2651,3304,2080,2472 -2.0288519737109936,0.9061027846832771,-0.013711595274741894,2.866397368803325,1.3008013122061457,0.4506749437853009,1.2657472734377568,-0.6909922588809689,0.5478694768628188,1.8900097097013104,0.776099228012361,2.285531889164803,-0.16113177748554827,-0.09758260109774661,1.105997161876891,-0.6909922588809689,-0.48762464822389984,-0.5772854996002308,0.5091440599781275,-0.7369966820229626,0.13076838476814698,2.483776090582276,0.13076838476814698,-0.37712313988404206,3.569421755662869,-0.7369966820229626,0.15117635458958095,0.71968985939333,2.223543950079106,0.4114378359281686,-1.1899723271023945,1.2657472734377568,1.1774078138827289,-0.16113177748554827,-0.18244015934691968,1.8575044941143102,-0.2252475557449799,2.254597454452404,-0.7833062289105431,0.08978035873173802,1.3877470096535027,2.5587558625495044,2.1296580535061174,1.9706953778300438,0.4506749437853009,-0.5099333245444402,-0.900446979133231,-0.28994201948861137,-0.44321720897869366 3643 Tetrapyrrole metabolic process 11 24 2.714523639873911 0.0066371163161009 O75027,Q9NPF0,P30536,O14678,P09601,O00264,P30519,Q7KZN9,P22830,Q96EY8,Q9NP58 Processes and pathways GO Biological process msigdb_gobp 260,524,106,301,175,236,93,378,564,414,447 236,301,260,1697,1985,175,564,93,106,2318,652,1184,2220,2509,378,414,966,447,524,2074,1277,970,3302,1105 1.6093549777202447,1.3877470096535027,1.5418361654019872,-0.13988634815318823,-0.2683121372291175,1.9385192969684373,0.7385400373905193,2.4535901140386045,2.377631431346862,-0.39908622494449625,0.6247218507870246,0.15117635458958095,-0.3552276637336356,-0.465386116003162,1.1417856605713883,1.0519984666463416,0.31242405485919195,0.9794004819604001,0.8134720365945656,-0.28994201948861137,0.11030317972784781,0.31242405485919195,-0.900446979133231,0.21206060116262693 3643 Vacuolar lumen 24 69 2.712582844347303 0.0066761091265017 P17900,Q8NBS9,O14773,P08236,P10253,Q9H7Z7,Q13217,Q9BWS9,P04066,P34059,P06280,Q9UM22,P54802,Q14108,Q8IV08,Q9UMR5,P04062,P61916,P38435,Q9BTY2,Q9NZJ7,P07602,Q8NHP8,P50897 Localization GO Cellular component msigdb_gocc 516,402,25,157,537,158,166,40,426,551,549,51,436,444,65,66,449,466,80,90,492,231,233,244 2948,1289,2415,25,1026,1621,449,426,549,1356,770,2952,231,3508,2361,157,537,2663,3509,880,2364,3555,582,1886,516,2544,2769,2547,551,80,3628,1671,1254,244,2609,2674,979,1673,436,2552,2773,466,3134,1594,3196,3049,166,3358,444,3055,65,402,233,1236,1903,1650,1772,1466,1685,90,40,3457,158,2979,492,51,66,2752,1174 -0.6681029929832263,0.08978035873173802,-0.44321720897869366,3.661517338984293,0.25237072765834473,-0.09758260109774661,0.9611422765478006,1.0157859516403132,0.7573430676997512,0.04856032582182117,0.4702158680735321,-0.6681029929832263,1.6261440706577892,-1.2146610216914933,-0.42111741427401633,2.034660375542446,0.776099228012361,-0.5323126699925248,-1.2146610216914933,0.37199154172998977,-0.42111741427401633,-1.3394678563793248,0.71968985939333,-0.2252475557449799,0.8134720365945656,-0.48762464822389984,-0.5772854996002308,-0.48762464822389984,0.7573430676997512,2.5587558625495044,-2.314556559776012,-0.11870343366061006,0.11030317972784781,1.592529825004484,-0.5099333245444402,-0.5323126699925248,0.29246072303462184,-0.11870343366061006,0.99761495810321,-0.48762464822389984,-0.5772854996002308,0.9244936801618757,-0.7601130162085916,-0.0765234222627171,-0.8065769270037231,-0.7139566269396745,1.9706953778300438,-0.9716940090710073,0.9794004819604001,-0.7139566269396745,2.808677111591547,1.0880399570282553,1.6261440706577892,0.13076838476814698,-0.2252475557449799,-0.09758260109774661,-0.16113177748554827,0.007105158915106008,-0.11870343366061006,2.4988272513624805,3.3006721207392853,-1.092100830903645,2.034660375542446,-0.6681029929832263,0.8691865207095048,3.037189084386894,2.808677111591547,-0.5547632158192415,0.17152746597699287 3643 N glycan biosynthesis 11 20 2.7088693477927785 0.0067512920023444 O60512,Q9BT22,Q13724,P04843,P04844,Q8TCJ2,O60476,P46977,Q96AA3,Q86YN1,Q14697 Processes and pathways KEGG Pathways msigdb_kegg 253,161,356,384,395,336,545,152,250,155,445 545,253,2801,2602,384,395,1551,1057,1736,1030,152,3544,356,445,1951,155,336,250,161,633 0.7573430676997512,1.5756684289722063,-0.5998800653389513,-0.5099333245444402,1.1239123190922105,1.105997161876891,-0.055525473592154824,0.23224335926748166,-0.16113177748554827,0.25237072765834473,2.06645172244257,-1.2892692909305767,1.1951570795527422,0.9794004819604001,-0.24674747021415624,2.050571853401436,1.2657472734377568,1.592529825004484,2.018717139797755,0.6628536231131278 3643 Abnormal mitochondria in muscle tissue 14 27 2.7052977735765653 0.0068243185501144 O75489,O96000,Q9Y4W6,O75251,O43676,O75380,Q9Y6M9,P56556,P00403,Q86Y39,Q8N183,Q96CU9,P03886,O75306 Drugs and Diseases Human Phenotype Ontology msigdb_hp 696,664,620,366,50,650,183,624,87,497,602,413,277,535 734,50,366,535,650,696,664,1885,87,277,953,3080,2605,1405,3129,624,497,865,602,1309,413,2235,1017,2405,1508,620,183 0.5091440599781275,3.107332731050088,1.1596174162013977,0.776099228012361,0.6247218507870246,0.5671569209643074,0.6055828069993638,-0.2252475557449799,2.5138506890054337,1.4566081122737937,0.31242405485919195,-0.7369966820229626,-0.5099333245444402,0.027862332156932304,-0.7601130162085916,0.6628536231131278,0.850660633843561,0.3917410017874763,0.7007922534137548,0.08978035873173802,1.0519984666463416,-0.3552276637336356,0.2724430641772754,-0.42111741427401633,-0.013711595274741894,0.6818469365208409,1.9062125107768622 3643 Cardiac muscle contraction 12 23 2.7006461454261483 0.0069204924685646 Q9UDW1,P13073,P16615,O14949,P67936,P47985,P20674,P00403,O14548,P14406,P22695,P31930 Processes and pathways KEGG Pathways msigdb_kegg 198,515,267,137,980,808,651,87,717,28,563,881 717,137,1885,87,976,1108,1984,1357,1446,1583,1252,515,28,1056,1218,267,651,563,881,808,2107,980,198 0.5285319592869173,2.1453820763492155,-0.2252475557449799,2.5138506890054337,0.29246072303462184,0.1918220918189678,-0.2683121372291175,0.04856032582182117,0.007105158915106008,-0.0765234222627171,0.11030317972784781,0.8134720365945656,3.5429255537908872,0.23224335926748166,0.13076838476814698,1.5078566888617457,0.6247218507870246,0.7385400373905193,0.37199154172998977,0.4310823742970927,-0.3116375849262432,0.29246072303462184,1.824865383027324 3643 Organic acid transmembrane transport 16 35 2.6937753113284617 0.0070647772395473 P23786,O43772,P11166,P31751,Q9Y619,O14678,P50416,P08183,Q9UBX3,Q02978,P41440,Q9H2D1,P53985,O60831,P28288,Q01650 Processes and pathways GO Biological process msigdb_gobp 255,663,514,550,694,301,709,303,144,79,213,286,409,434,759,376 301,663,434,1733,1883,1580,1445,303,1400,514,255,759,771,2770,550,1887,2318,213,709,1491,409,376,79,915,1301,1233,2180,2583,3566,1014,286,1313,144,1434,694 1.3877470096535027,0.6055828069993638,0.99761495810321,-0.16113177748554827,-0.2252475557449799,-0.0765234222627171,0.007105158915106008,1.3877470096535027,0.027862332156932304,0.8134720365945656,1.5756684289722063,0.4897054676751104,0.4702158680735321,-0.5772854996002308,0.7573430676997512,-0.2252475557449799,-0.39908622494449625,1.692943464578411,0.5478694768628188,-0.013711595274741894,1.0700404706148139,1.1417856605713883,2.5885562139486704,0.3521891223123161,0.08978035873173802,0.13076838476814698,-0.333399306791712,-0.48762464822389984,-1.390041774081608,0.2724430641772754,1.4566081122737937,0.08978035873173802,2.1296580535061174,0.027862332156932304,0.5863945968863824 3643 Metalloendopeptidase activity 8 15 2.6931508638837807 0.0070780233534231 P78536,P52888,Q5JRX3,Q9BYT8,Q92905,O43847,O75844,P22695 Functions GO Molecular function msigdb_gomf 226,325,35,141,77,578,217,563 578,879,217,1401,563,955,325,226,1093,35,77,841,866,141,620 0.71968985939333,0.37199154172998977,1.659614804060893,0.027862332156932304,0.7385400373905193,0.31242405485919195,1.3008013122061457,1.64289728589414,0.21206060116262693,3.4495350664729076,2.6034158117050517,0.4114378359281686,0.3917410017874763,2.1296580535061174,0.6818469365208409 3643 Horizontal nystagmus 7 24 2.692842605183704 0.0070845705197339 O95831,P04062,P07602,Q9NSE4,Q9H061,O94905,O14773 Drugs and Diseases Human Phenotype Ontology msigdb_hp 195,449,231,182,148,334,25 2982,1249,25,1353,847,334,195,1000,449,231,756,1586,1800,1522,1328,1033,2428,2830,1199,1163,148,182,492,2651 -0.6909922588809689,0.11030317972784781,3.661517338984293,0.04856032582182117,0.3917410017874763,1.2657472734377568,1.824865383027324,0.2724430641772754,0.9611422765478006,1.6261440706577892,0.4897054676751104,-0.0765234222627171,-0.18244015934691968,-0.03458833609287247,0.06919953703395551,0.25237072765834473,-0.44321720897869366,-0.5998800653389513,0.15117635458958095,0.17152746597699287,2.0981172248521958,1.9062125107768622,0.8691865207095048,-0.5099333245444402 3643 Nuclear inner membrane 9 24 2.6917472636826365 0.0071078787008425 Q9UH99,O75844,Q8N6S5,P50402,Q9H1E5,Q9BTV4,Q8IXM6,Q14739,Q5SNT2 Localization GO Cellular component msigdb_gocc 164,217,104,396,181,311,89,281,377 217,3390,769,1586,1521,1002,396,3414,485,959,1409,814,281,1810,377,89,104,1461,2067,656,311,181,164,926 1.659614804060893,-1.019604048841438,0.4702158680735321,-0.0765234222627171,-0.03458833609287247,0.2724430641772754,1.105997161876891,-1.0436847151728275,0.8691865207095048,0.31242405485919195,0.027862332156932304,0.4310823742970927,1.4566081122737937,-0.18244015934691968,1.1417856605713883,2.4988272513624805,2.3928800946790516,0.007105158915106008,-0.28994201948861137,0.6247218507870246,1.3356969350852728,1.9062125107768622,1.9867347928109564,0.3521891223123161 3643 Decreased activity of mitochondrial complex i 20 37 2.688401270870946 0.0071795063032438 Q9UBX3,O75380,Q96CU9,O75648,P03886,O75306,O96000,O43676,Q9Y584,Q9Y6M9,O75489,Q5JPH6,Q8N183,Q96EY7,Q70HW3,O75251,O00217,P56556,Q86Y39,Q9H0R6 Drugs and Diseases Human Phenotype Ontology msigdb_hp 144,650,413,536,277,535,664,50,308,183,696,834,602,747,357,366,734,624,497,510 734,50,366,535,650,696,536,664,277,3080,2605,1939,3129,1328,2045,624,834,2509,357,497,865,602,1309,1861,413,747,1240,2235,510,993,1017,2405,1508,144,1437,308,183 0.5091440599781275,3.107332731050088,1.1596174162013977,0.776099228012361,0.6247218507870246,0.5671569209643074,0.776099228012361,0.6055828069993638,1.4566081122737937,-0.7369966820229626,-0.5099333245444402,-0.24674747021415624,-0.7601130162085916,0.06919953703395551,-0.28994201948861137,0.6628536231131278,0.4114378359281686,-0.465386116003162,1.1951570795527422,0.850660633843561,0.3917410017874763,0.7007922534137548,0.08978035873173802,-0.2038119362780547,1.0519984666463416,0.5091440599781275,0.13076838476814698,-0.3552276637336356,0.832089227524965,0.29246072303462184,0.2724430641772754,-0.42111741427401633,-0.013711595274741894,2.1296580535061174,0.027862332156932304,1.3704358233118867,1.9062125107768622 3643 Cholesterol binding 9 16 2.6861358772462127 0.007228368674276 O75477,P45880,P30536,O95772,P61916,O94905,Q9H4L5,Q14108,P21796 Functions GO Molecular function msigdb_gomf 322,261,106,394,466,334,345,444,278 2416,322,334,394,3079,278,2316,106,783,261,466,444,555,1607,1470,345 -0.44321720897869366,1.3008013122061457,1.2657472734377568,1.105997161876891,-0.7369966820229626,1.4566081122737937,-0.39908622494449625,2.377631431346862,0.4506749437853009,1.5418361654019872,0.9244936801618757,0.9794004819604001,0.7573430676997512,-0.0765234222627171,0.007105158915106008,1.2481603149029503 3643 Lumenal side of endoplasmic reticulum membrane 7 10 2.682321964920524 0.0073113056305433 P30511,O15533,P51572,Q8TCT9,P10321,P27824,P27797 Localization GO Cellular component msigdb_gocc 6,329,397,364,48,118,539 329,1139,579,48,539,118,6,397,1762,364 1.2832942009953483,0.17152746597699287,0.71968985939333,3.135226461008061,0.776099228012361,2.285531889164803,4.673387267370069,1.105997161876891,-0.16113177748554827,1.1774078138827289 3643 Mitochondrial myopathy 19 35 2.6782064262479683 0.0074017585909982 O75380,Q96CU9,P03886,O75306,O96000,Q9BUK6,O43676,Q9Y6M9,O75489,P12235,Q8IUX1,Q7LG56,P00403,Q96RR1,Q8N183,O75251,O00217,P56556,Q86Y39 Drugs and Diseases Human Phenotype Ontology msigdb_hp 650,413,277,535,664,45,50,183,696,581,865,864,87,603,602,366,734,624,497 734,50,847,366,535,650,696,664,1885,87,1000,277,953,581,3080,2605,3129,1221,624,1896,864,497,865,602,1309,413,603,2235,45,1017,2405,1508,1923,1925,183 0.5091440599781275,3.107332731050088,0.3917410017874763,1.1596174162013977,0.776099228012361,0.6247218507870246,0.5671569209643074,0.6055828069993638,-0.2252475557449799,2.5138506890054337,0.2724430641772754,1.4566081122737937,0.31242405485919195,0.71968985939333,-0.7369966820229626,-0.5099333245444402,-0.7601130162085916,0.13076838476814698,0.6628536231131278,-0.2252475557449799,0.3917410017874763,0.850660633843561,0.3917410017874763,0.7007922534137548,0.08978035873173802,1.0519984666463416,0.7007922534137548,-0.3552276637336356,3.204557850940264,0.2724430641772754,-0.42111741427401633,-0.013711595274741894,-0.2252475557449799,-0.2252475557449799,1.9062125107768622 3643 Glycolipid binding 7 11 2.674916983353904 0.0074747756897282 P07602,Q9UM22,P50897,O14773,Q92643,Q9NWW5,O43292 Functions GO Molecular function msigdb_gomf 231,51,244,25,187,252,373 25,373,231,244,958,1525,187,252,3210,492,51 3.661517338984293,1.1417856605713883,1.6261440706577892,1.592529825004484,0.31242405485919195,-0.03458833609287247,1.8575044941143102,1.592529825004484,-0.8065769270037231,0.8691865207095048,3.037189084386894 3643 Sterol binding 9 19 2.6744461243357085 0.0074852802210838 O75477,P45880,P30536,O95772,P61916,O94905,Q9H4L5,Q14108,P21796 Functions GO Molecular function msigdb_gomf 322,261,106,394,466,334,345,444,278 2416,322,334,394,3079,278,2488,2316,106,783,261,466,444,555,1963,1774,1607,1470,345 -0.44321720897869366,1.3008013122061457,1.2657472734377568,1.105997161876891,-0.7369966820229626,1.4566081122737937,-0.465386116003162,-0.39908622494449625,2.377631431346862,0.4506749437853009,1.5418361654019872,0.9244936801618757,0.9794004819604001,0.7573430676997512,-0.24674747021415624,-0.16113177748554827,-0.0765234222627171,0.007105158915106008,1.2481603149029503 3643 Glycolipid biosynthetic process 9 12 2.673920703655737 0.0074970176112758 O60512,Q8NBX0,Q969N2,Q96S52,Q5H8A4,Q16739,Q16880,Q92643,O43292 Processes and pathways GO Biological process msigdb_gobp 253,33,586,234,207,282,246,187,373 373,253,2801,282,246,207,33,187,586,234,1165,649 1.1417856605713883,1.5756684289722063,-0.5998800653389513,1.4566081122737937,1.592529825004484,1.742673161727919,3.476322734521235,1.8575044941143102,0.71968985939333,1.6261440706577892,0.17152746597699287,0.6438120248840904 3643 Endoplasmic reticulum 88 220 2.67260815446513 0.0075264108363177 Q6UW68,P27544,Q86Y07,O96005,Q8WUJ1,O95674,P43307,O43852,Q86XL3,Q14257,Q96AG4,Q4ZIN3,P27797,P51648,Q8NF37,Q9Y680,P07237,P13674,O15260,Q96G23,Q9P2W9,Q8IV08,Q70UQ0,Q5T9L3,Q13162,P37268,Q86UE4,Q13438,P84157,Q92791,P27824,Q9BUN8,P30533,Q96PC5,Q9BT22,Q9UKV5,Q13217,O43169,P14625,Q96A33,Q9BRK0,Q96KA5,O15460,Q15293,Q96GC9,O95470,Q96S66,Q9UGP8,Q96KC8,O95197,P49257,O00264,Q9NWW5,Q9UM00,Q14696,Q9H3N1,Q9H6H4,P14314,O75477,Q8TCJ2,Q9P035,O94905,Q9H3G5,P30101,Q13724,Q8TCT9,Q9NQC3,P61619,Q12981,O43292,P04843,P51572,P04844,P50402,P51571,Q8NBS9,Q9HCU5,Q96A57,Q15084,O60831,P13667,Q14697,Q99442,O14967,Q12797,Q6PIU2,Q15800,Q8N0U8 Localization Protein Atlas Subcellular protein_atlas_subcellular_location_all 1,5,520,9,10,513,14,16,18,20,542,27,539,32,557,39,41,47,52,55,58,65,70,69,72,73,85,91,94,113,118,122,132,154,161,169,166,174,184,188,189,192,194,203,208,209,219,221,228,223,238,236,252,259,263,297,312,324,322,336,340,334,344,352,356,364,365,363,367,373,384,397,395,396,400,402,415,422,419,434,443,445,467,469,481,488,487,498 236,875,824,469,755,52,611,194,174,2950,373,2357,16,621,434,848,322,805,1883,3390,1214,334,223,2035,209,513,9,1621,384,395,2420,3594,1445,41,2991,2992,638,2852,580,443,47,324,184,1447,1402,2666,2485,1623,3563,782,2667,2099,2546,5,758,539,118,2955,352,132,3488,1937,783,772,908,73,1030,2860,14,1590,2548,1940,2103,1670,1632,3564,2821,238,396,909,3047,400,397,32,1525,2772,1997,2047,2328,1063,363,3544,2110,3005,2822,2962,1115,2373,2775,3396,2165,2374,1455,2919,1456,2329,2823,1297,2920,1408,1745,2921,641,2050,1846,94,681,829,3049,2923,481,367,2617,72,166,2114,91,356,20,2567,263,445,555,915,1893,419,203,2870,1152,487,1095,3170,27,3234,1120,69,2060,2930,488,1529,1,70,85,1418,18,520,65,3235,498,1645,402,557,837,2634,336,364,1338,10,1764,113,728,188,422,542,1818,1903,654,55,208,890,192,228,154,219,467,618,1468,1605,189,2018,161,122,633,1775,1610,344,297,312,415,365,995,2023,252,1828,1315,798,340,1785,3613,1718,58,1280,660,1080,221,169,259,2411,39,873 1.6093549777202447,0.37199154172998977,0.4114378359281686,0.9061027846832771,0.4897054676751104,3.0230894408053492,0.6818469365208409,1.824865383027324,1.9385192969684373,-0.6681029929832263,1.1417856605713883,-0.42111741427401633,4.095354306912875,0.6628536231131278,0.99761495810321,0.3917410017874763,1.3008013122061457,0.4310823742970927,-0.2252475557449799,-1.019604048841438,0.13076838476814698,1.2657472734377568,1.64289728589414,-0.28994201948861137,1.7095549611048153,0.8134720365945656,4.243451171065863,-0.09758260109774661,1.1239123190922105,1.105997161876891,-0.44321720897869366,-1.6752169966089951,0.007105158915106008,3.2870083892475765,-0.6909922588809689,-0.6909922588809689,0.6438120248840904,-0.6225474635721432,0.71968985939333,0.9794004819604001,3.163027731650402,1.3008013122061457,1.8900097097013104,0.007105158915106008,0.027862332156932304,-0.5323126699925248,-0.465386116003162,-0.09758260109774661,-1.390041774081608,0.4506749437853009,-0.5323126699925248,-0.3116375849262432,-0.48762464822389984,4.73149126850177,0.4897054676751104,0.776099228012361,2.285531889164803,-0.6681029929832263,1.2128654372087189,2.192370287416088,-1.1653727114302805,-0.24674747021415624,0.4506749437853009,0.4702158680735321,0.3521891223123161,2.647833677324652,0.25237072765834473,-0.6225474635721432,4.1449986542955966,-0.0765234222627171,-0.48762464822389984,-0.24674747021415624,-0.3116375849262432,-0.11870343366061006,-0.09758260109774661,-1.390041774081608,-0.5998800653389513,1.6093549777202447,1.105997161876891,0.3521891223123161,-0.7139566269396745,1.0880399570282553,1.105997161876891,3.476322734521235,-0.03458833609287247,-0.5772854996002308,-0.2683121372291175,-0.28994201948861137,-0.39908622494449625,0.23224335926748166,1.1774078138827289,-1.2892692909305767,-0.3116375849262432,-0.6909922588809689,-0.5998800653389513,-0.6681029929832263,0.1918220918189678,-0.42111741427401633,-0.5772854996002308,-1.019604048841438,-0.333399306791712,-0.42111741427401633,0.007105158915106008,-0.6452882514774274,0.007105158915106008,-0.39908622494449625,-0.5998800653389513,0.08978035873173802,-0.6452882514774274,0.027862332156932304,-0.16113177748554827,-0.6452882514774274,0.6438120248840904,-0.28994201948861137,-0.2038119362780547,2.4535901140386045,0.5863945968863824,0.4114378359281686,-0.7139566269396745,-0.6452882514774274,0.8876671508686171,1.1596174162013977,-0.5099333245444402,2.692012537294508,1.9706953778300438,-0.3116375849262432,2.483776090582276,1.1951570795527422,3.8042718536546554,-0.48762464822389984,1.5418361654019872,0.9794004819604001,0.7573430676997512,0.3521891223123161,-0.2252475557449799,1.0339137070490352,1.792091065872174,-0.6225474635721432,0.17152746597699287,0.8691865207095048,0.21206060116262693,-0.7833062289105431,3.569421755662869,-0.829925724951396,0.1918220918189678,2.7651210132024806,-0.28994201948861137,-0.6452882514774274,0.8691865207095048,-0.03458833609287247,5.873073786689076,2.7651210132024806,2.5288465238651407,0.027862332156932304,3.906629108755367,0.8134720365945656,2.808677111591547,-0.829925724951396,0.850660633843561,-0.09758260109774661,1.0880399570282553,0.7573430676997512,0.4114378359281686,-0.5099333245444402,1.2657472734377568,1.1774078138827289,0.06919953703395551,4.231204838358074,-0.16113177748554827,2.3470478270665613,0.5285319592869173,1.8575044941143102,1.0339137070490352,0.776099228012361,-0.18244015934691968,-0.2252475557449799,0.6247218507870246,2.980646976640566,1.7261314689431049,0.37199154172998977,1.8412017569470738,1.64289728589414,2.06645172244257,1.659614804060893,0.9244936801618757,0.6818469365208409,0.007105158915106008,-0.0765234222627171,1.8575044941143102,-0.2683121372291175,2.018717139797755,2.254597454452404,0.6628536231131278,-0.16113177748554827,-0.0765234222627171,1.2481603149029503,1.4050196301598754,1.3356969350852728,1.0519984666463416,1.1774078138827289,0.29246072303462184,-0.2683121372291175,1.592529825004484,-0.18244015934691968,0.08978035873173802,0.4506749437853009,1.2657472734377568,-0.16113177748554827,-1.890577869245987,-0.13988634815318823,2.9094252815894692,0.11030317972784781,0.6247218507870246,0.23224335926748166,1.659614804060893,1.9706953778300438,1.5587706046077934,-0.42111741427401633,3.314313786509081,0.3917410017874763 3643 Nuclear membrane 17 70 2.6677481351653496 0.0076361478485729 Q6UW68,P67812,Q9UH99,Q8N6S5,Q9BTZ2,Q9H8M7,P50402,Q9BVC6,Q9BTX1,Q9H1E5,O15260,Q96SK2,Q96G23,Q8IXM6,Q14739,Q5SNT2,O94919 Localization Protein Atlas Subcellular protein_atlas_subcellular_location_all 1,128,164,104,139,430,396,305,178,181,52,310,55,89,281,377,31 2083,1083,2948,3617,3262,2356,52,2247,562,2987,3530,769,31,470,3078,851,2036,3522,1586,1800,3314,3191,1032,396,1258,1259,128,959,814,281,3359,1810,377,1,3420,89,2175,104,1461,2178,2578,1603,1201,55,939,310,2521,1905,2700,2019,178,139,305,1773,2702,2525,181,430,2404,1130,1315,164,2646,2795,2466,926,1437,2980,2149,1021 -0.3116375849262432,0.21206060116262693,-0.6681029929832263,-2.0288519737109936,-0.8768601169890071,-0.42111741427401633,3.0230894408053492,-0.37712313988404206,0.7385400373905193,-0.6909922588809689,-1.2643087218937006,0.4702158680735321,3.476322734521235,0.9061027846832771,-0.7369966820229626,0.3917410017874763,-0.28994201948861137,-1.239439561156638,-0.0765234222627171,-0.18244015934691968,-0.9241144775154201,-0.8065769270037231,0.25237072765834473,1.105997161876891,0.11030317972784781,0.11030317972784781,2.223543950079106,0.31242405485919195,0.4310823742970927,1.4566081122737937,-0.9716940090710073,-0.18244015934691968,1.1417856605713883,5.873073786689076,-1.0436847151728275,2.4988272513624805,-0.333399306791712,2.3928800946790516,0.007105158915106008,-0.333399306791712,-0.48762464822389984,-0.0765234222627171,0.15117635458958095,2.980646976640566,0.33233340674752826,1.3530858670526362,-0.465386116003162,-0.2252475557449799,-0.5323126699925248,-0.2683121372291175,1.9223823204371768,2.1453820763492155,1.3877470096535027,-0.16113177748554827,-0.5323126699925248,-0.465386116003162,1.9062125107768622,1.0157859516403132,-0.42111741427401633,0.1918220918189678,0.08978035873173802,1.9867347928109564,-0.5099333245444402,-0.5772854996002308,-0.44321720897869366,0.3521891223123161,0.027862332156932304,-0.6681029929832263,-0.3116375849262432,0.2724430641772754 3643 Alzheimers disease 30 69 2.665147713991433 0.0076954512582128 P05067,O75438,P13073,O14949,P16615,Q92542,P20674,O75380,P21912,P14406,O75306,O96000,O95139,P47985,O43676,Q9Y6M9,P22695,O75489,Q9UDW1,O43674,O95168,P00403,O95167,O14548,P06576,P78536,P24539,O75251,O00217,P56556 Processes and pathways KEGG Pathways msigdb_kegg 385,768,515,137,267,531,651,650,538,28,535,664,548,808,50,183,563,696,198,321,470,87,341,717,92,226,362,366,734,624 1482,734,1875,717,137,321,50,2358,366,535,650,768,696,1138,548,341,470,806,1515,2155,664,1885,87,1000,3078,385,92,3159,1357,1583,1930,1252,515,28,1401,1056,1218,267,3336,1932,3080,651,538,563,362,1517,3376,2605,2769,1405,881,1141,808,3463,2550,3129,1742,624,226,3464,3315,2686,1498,2280,531,3258,198,1921,183 -0.013711595274741894,0.5091440599781275,-0.2252475557449799,0.5285319592869173,2.1453820763492155,1.3008013122061457,3.107332731050088,-0.42111741427401633,1.1596174162013977,0.776099228012361,0.6247218507870246,0.4702158680735321,0.5671569209643074,0.17152746597699287,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.6055828069993638,-0.2252475557449799,2.5138506890054337,0.2724430641772754,-0.7369966820229626,1.1239123190922105,2.4535901140386045,-0.7833062289105431,0.04856032582182117,-0.0765234222627171,-0.24674747021415624,0.11030317972784781,0.8134720365945656,3.5429255537908872,0.027862332156932304,0.23224335926748166,0.13076838476814698,1.5078566888617457,-0.947863266551478,-0.24674747021415624,-0.7369966820229626,0.6247218507870246,0.776099228012361,0.7385400373905193,1.1774078138827289,-0.03458833609287247,-0.9956073764657654,-0.5099333245444402,-0.5772854996002308,0.027862332156932304,0.37199154172998977,0.17152746597699287,0.4310823742970927,-1.1164377040450824,-0.48762464822389984,-0.7601130162085916,-0.16113177748554827,0.6628536231131278,1.64289728589414,-1.1164377040450824,-0.9241144775154201,-0.5323126699925248,-0.013711595274741894,-0.37712313988404206,0.7948087934495096,-0.8533532449353657,1.824865383027324,-0.2252475557449799,1.9062125107768622 3643 Platyspondyly 14 36 2.663547489043681 0.0077321497154816 P48735,O95831,Q02809,P04066,P34059,P00813,Q32P28,O75874,Q96AY3,Q5JRA6,Q7RTS9,O60568,Q14739,P08236 Drugs and Diseases Human Phenotype Ontology msigdb_hp 97,195,613,426,551,11,12,457,75,342,343,493,281,157 822,2415,493,3427,457,2805,195,11,426,157,1886,3449,2667,2546,2606,551,97,909,1329,2375,613,281,2826,12,342,1269,1066,343,2175,1375,75,890,631,1383,869,1788 0.4114378359281686,-0.44321720897869366,0.850660633843561,-1.0678500734626066,0.9428400929877672,-0.5998800653389513,1.824865383027324,4.206660830311199,1.0157859516403132,2.034660375542446,-0.2252475557449799,-1.092100830903645,-0.5323126699925248,-0.48762464822389984,-0.5099333245444402,0.7573430676997512,2.438455053388052,0.3521891223123161,0.06919953703395551,-0.42111741427401633,0.6818469365208409,1.4566081122737937,-0.5998800653389513,4.206660830311199,1.2481603149029503,0.11030317972784781,0.23224335926748166,1.2481603149029503,-0.333399306791712,0.04856032582182117,2.633054429019238,0.37199154172998977,0.6628536231131278,0.04856032582182117,0.3917410017874763,-0.16113177748554827 3643 Impaired proprioception 19 48 2.6630359588211747 0.0077439138326445 Q9H6K4,O00165,Q96RL7,O14773,P07196,Q13217,Q9NR77,O75298,P54802,Q9BRK0,Q8IV08,O43819,O94905,P41440,Q96RR1,Q00796,Q02809,Q15120,O00400 Drugs and Diseases Human Phenotype Ontology msigdb_hp 264,382,532,25,291,166,42,546,436,189,65,333,334,213,603,474,613,494,123 382,123,25,2203,1353,333,546,334,999,1000,2810,291,2994,2158,2486,1586,2215,2492,213,1221,436,1033,2552,474,613,627,1226,166,3378,494,3204,724,2226,1304,65,963,1199,532,603,189,868,264,42,3446,2651,2081,694,873 1.1239123190922105,2.239085653646518,3.661517338984293,-0.3552276637336356,0.04856032582182117,1.2657472734377568,0.7573430676997512,1.2657472734377568,0.2724430641772754,0.2724430641772754,-0.5998800653389513,1.4222538872246275,-0.6909922588809689,-0.333399306791712,-0.465386116003162,-0.0765234222627171,-0.3552276637336356,-0.465386116003162,1.692943464578411,0.13076838476814698,0.99761495810321,0.25237072765834473,-0.48762464822389984,0.9061027846832771,0.6818469365208409,0.6628536231131278,0.13076838476814698,1.9706953778300438,-0.9956073764657654,0.850660633843561,-0.8065769270037231,0.5285319592869173,-0.3552276637336356,0.08978035873173802,2.808677111591547,0.31242405485919195,0.15117635458958095,0.7948087934495096,0.7007922534137548,1.8575044941143102,0.3917410017874763,1.5418361654019872,3.2733225075135053,-1.0678500734626066,-0.5099333245444402,-0.28994201948861137,0.5863945968863824,0.3917410017874763 3643 Organophosphate ester transmembrane transporter activity 9 16 2.658672663423513 0.0078449141353582 Q9BSK2,Q9HC21,P12235,Q86VD7,P41440,Q8TB61,Q6KCM7,Q9H2D1,O00400 Functions GO Molecular function msigdb_gomf 327,619,581,177,213,410,701,286,123 123,1176,779,1581,581,904,213,701,1269,177,1233,410,1127,327,286,619 2.239085653646518,0.15117635458958095,0.4506749437853009,-0.0765234222627171,0.71968985939333,0.3521891223123161,1.692943464578411,0.5671569209643074,0.11030317972784781,1.9223823204371768,0.13076838476814698,1.0700404706148139,0.1918220918189678,1.3008013122061457,1.4566081122737937,0.6818469365208409 3643 Nucleotide transmembrane transporter activity 9 16 2.658672663423513 0.0078449141353582 Q9BSK2,Q9HC21,P12235,Q86VD7,P41440,Q8TB61,Q6KCM7,Q9H2D1,O00400 Functions GO Molecular function msigdb_gomf 327,619,581,177,213,410,701,286,123 123,1176,779,1581,581,904,213,701,1269,177,1233,410,1127,327,286,619 2.239085653646518,0.15117635458958095,0.4506749437853009,-0.0765234222627171,0.71968985939333,0.3521891223123161,1.692943464578411,0.5671569209643074,0.11030317972784781,1.9223823204371768,0.13076838476814698,1.0700404706148139,0.1918220918189678,1.3008013122061457,1.4566081122737937,0.6818469365208409 3643 Nadh dehydrogenase complex 17 30 2.652977754514985 0.0079785128897922 O75489,O96000,O43674,O75438,O95139,O75251,O00217,O43676,O75380,Q9Y6M9,O95168,P56556,Q86Y39,O95167,Q96CU9,P03886,O75306 Localization GO Cellular component msigdb_gocc 696,664,321,768,548,366,734,50,650,183,470,624,497,341,413,277,535 734,1875,321,50,2358,366,535,650,768,696,548,341,470,806,1515,2155,664,277,953,3080,2605,3129,624,1498,2280,497,413,2405,1349,183 0.5091440599781275,-0.2252475557449799,1.3008013122061457,3.107332731050088,-0.42111741427401633,1.1596174162013977,0.776099228012361,0.6247218507870246,0.4702158680735321,0.5671569209643074,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.6055828069993638,1.4566081122737937,0.31242405485919195,-0.7369966820229626,-0.5099333245444402,-0.7601130162085916,0.6628536231131278,-0.013711595274741894,-0.37712313988404206,0.850660633843561,1.0519984666463416,-0.42111741427401633,0.06919953703395551,1.9062125107768622 3643 Abnormal circulating lipid concentration 36 79 2.647596606536699 0.0081066193777386 P23786,Q8N511,P50402,P16219,Q8NI22,Q4G0N4,Q14739,O43707,O75648,P40855,Q15392,O43772,Q92734,P28070,P31751,P06280,Q15904,O75845,Q9BTV4,P40939,P22830,Q9Y4P3,Q969N2,P37268,P02545,P50416,Q9NVI7,P61916,O95470,O75844,O75880,Q9NZJ7,P07602,Q15800,Q9BV10,P49257 Drugs and Diseases Human Phenotype Ontology msigdb_hp 255,13,396,526,22,149,281,778,536,666,160,663,819,170,550,549,815,805,311,698,564,193,586,73,826,709,339,466,209,217,718,492,231,487,633,238 2203,778,2205,663,1137,1695,536,217,805,718,209,3632,826,549,1325,231,2363,3615,526,564,255,170,2212,550,1737,3225,2216,1448,73,3628,666,698,1672,238,1183,396,709,1522,3251,957,2863,2675,1259,466,3048,2375,959,1750,1457,3378,2004,281,984,160,1152,487,2778,815,885,149,13,2131,22,1603,819,586,311,633,993,1277,339,492,1280,2648,1434,1616,193,1479,873 -0.3552276637336356,0.4506749437853009,-0.3552276637336356,0.6055828069993638,0.17152746597699287,-0.13988634815318823,0.776099228012361,1.659614804060893,0.4310823742970927,0.5285319592869173,1.7095549611048153,-2.863473284482365,0.4114378359281686,0.7573430676997512,0.06919953703395551,1.6261440706577892,-0.42111741427401633,-1.9731908618321436,0.7948087934495096,0.7385400373905193,1.5756684289722063,1.9546235974626718,-0.3552276637336356,0.7573430676997512,-0.16113177748554827,-0.829925724951396,-0.3552276637336356,0.007105158915106008,2.647833677324652,-2.314556559776012,0.6055828069993638,0.5671569209643074,-0.11870343366061006,1.6093549777202447,0.15117635458958095,1.105997161876891,0.5478694768628188,-0.03458833609287247,-0.8533532449353657,0.31242405485919195,-0.6225474635721432,-0.5323126699925248,0.11030317972784781,0.9244936801618757,-0.7139566269396745,-0.42111741427401633,0.31242405485919195,-0.16113177748554827,0.007105158915106008,-0.9956073764657654,-0.2683121372291175,1.4566081122737937,0.29246072303462184,2.018717139797755,0.17152746597699287,0.8691865207095048,-0.5772854996002308,0.4310823742970927,0.37199154172998977,2.08230013063339,4.206660830311199,-0.3116375849262432,3.7655729970606435,-0.0765234222627171,0.4310823742970927,0.71968985939333,1.3356969350852728,0.6628536231131278,0.29246072303462184,0.11030317972784781,1.2657472734377568,0.8691865207095048,0.11030317972784781,-0.5099333245444402,0.027862332156932304,-0.0765234222627171,1.8412017569470738,0.007105158915106008,0.3917410017874763 3643 Disulfide oxidoreductase activity 13 24 2.6325210774012566 0.0084753764017446 Q8IXB1,Q9Y320,P30101,Q15084,O43396,P07237,Q9H3N1,Q14554,O95881,O43819,Q96HE7,P13667,Q96JJ7 Functions GO Molecular function msigdb_gomf 129,448,352,419,383,41,297,108,237,333,411,443,350 383,333,3485,237,2255,3351,41,443,352,3431,3417,108,419,2056,1231,989,3440,530,129,411,350,1606,297,448 1.1239123190922105,1.2657472734377568,-1.1653727114302805,1.6093549777202447,-0.37712313988404206,-0.9716940090710073,3.2870083892475765,0.9794004819604001,1.2128654372087189,-1.0678500734626066,-1.0436847151728275,2.377631431346862,1.0339137070490352,-0.28994201948861137,0.13076838476814698,0.29246072303462184,-1.0678500734626066,0.7948087934495096,2.223543950079106,1.0700404706148139,1.2305331089305223,-0.0765234222627171,1.4050196301598754,0.9794004819604001 3643 Increased csf lactate 29 60 2.629049683871669 0.0085623850176133 P13073,P30084,O75380,P30038,Q96CU9,P03886,O75306,O96000,O95169,O43676,Q9Y6M9,Q8NCW5,Q8NI60,O75489,O95831,P08559,Q8IUX1,O43819,Q9NWS8,P00403,Q8N183,Q9HC21,O75251,O00217,P56556,Q7KZN9,Q86Y39,P0DJ07,P39210 Drugs and Diseases Human Phenotype Ontology msigdb_hp 515,528,650,407,413,277,535,664,806,50,183,317,446,696,195,451,865,333,607,87,602,619,366,734,624,378,497,756,505 734,1084,1875,50,2358,333,366,535,650,696,806,2155,195,664,1885,87,1000,277,953,451,756,515,3080,2605,407,528,1405,1519,505,3510,1521,3129,2673,2045,624,1747,2280,859,2226,378,2390,497,865,602,317,446,1309,1961,413,1683,1240,3258,2235,619,1017,607,2405,1508,1349,183 0.5091440599781275,0.21206060116262693,-0.2252475557449799,3.107332731050088,-0.42111741427401633,1.2657472734377568,1.1596174162013977,0.776099228012361,0.6247218507870246,0.5671569209643074,0.4310823742970927,-0.333399306791712,1.824865383027324,0.6055828069993638,-0.2252475557449799,2.5138506890054337,0.2724430641772754,1.4566081122737937,0.31242405485919195,0.9611422765478006,0.4897054676751104,0.8134720365945656,-0.7369966820229626,-0.5099333245444402,1.0700404706148139,0.7948087934495096,0.027862332156932304,-0.03458833609287247,0.832089227524965,-1.2146610216914933,-0.03458833609287247,-0.7601130162085916,-0.5323126699925248,-0.28994201948861137,0.6628536231131278,-0.16113177748554827,-0.37712313988404206,0.3917410017874763,-0.3552276637336356,1.1417856605713883,-0.42111741427401633,0.850660633843561,0.3917410017874763,0.7007922534137548,1.318268819891666,0.9794004819604001,0.08978035873173802,-0.24674747021415624,1.0519984666463416,-0.11870343366061006,0.13076838476814698,-0.8533532449353657,-0.3552276637336356,0.6818469365208409,0.2724430641772754,0.7007922534137548,-0.42111741427401633,-0.013711595274741894,0.06919953703395551,1.9062125107768622 3643 Translocase 13 28 2.622455896398867 0.0087298565969227 O75489,Q9HD20,Q9NP58,P16615,O75251,P08183,P47985,O00217,Q13423,P00403,P06576,P03886,O75306 Functions Protein Atlas Molecular function protein_atlas_molecular_function 696,136,447,267,366,303,808,734,114,87,92,277,535 734,1176,366,535,696,1885,87,277,953,976,92,303,1357,267,3080,1553,1624,2605,2318,1588,808,3129,1117,829,114,2012,136,447 0.5091440599781275,0.15117635458958095,1.1596174162013977,0.776099228012361,0.5671569209643074,-0.2252475557449799,2.5138506890054337,1.4566081122737937,0.31242405485919195,0.29246072303462184,2.4535901140386045,1.3877470096535027,0.04856032582182117,1.5078566888617457,-0.7369966820229626,-0.055525473592154824,-0.09758260109774661,-0.5099333245444402,-0.39908622494449625,-0.0765234222627171,0.4310823742970927,-0.7601130162085916,0.1918220918189678,0.4114378359281686,2.331712628995581,-0.2683121372291175,2.1610753620574217,0.9794004819604001 3643 Disproportionate short limb short stature 8 22 2.616542433208388 0.0088825323143271 Q15392,Q9Y366,O75718,Q14696,Q32P28,O15228,Q7RTS9,Q14739 Drugs and Diseases Human Phenotype Ontology msigdb_hp 160,525,99,263,12,465,343,281 1319,465,3427,99,2805,1216,2667,1091,1941,263,281,160,12,1231,1813,343,1234,1375,2133,633,1280,525 0.06919953703395551,0.9244936801618757,-1.0678500734626066,2.423291779810149,-0.5998800653389513,0.13076838476814698,-0.5323126699925248,0.21206060116262693,-0.24674747021415624,1.5418361654019872,1.4566081122737937,2.018717139797755,4.206660830311199,0.13076838476814698,-0.18244015934691968,1.2481603149029503,0.13076838476814698,0.04856032582182117,-0.3116375849262432,0.6628536231131278,0.11030317972784781,0.8134720365945656 3643 Post translational protein modification 6 13 2.6001380712969184 0.0093186258842603 O75718,Q32P28,Q92905,P46977,Q9HA64,O60725 Processes and pathways GO Biological process msigdb_gobp 99,12,77,152,185,62 62,99,2479,2667,152,3339,12,1901,336,77,3404,1777,185 2.837587540785622,2.423291779810149,-0.465386116003162,-0.5323126699925248,2.06645172244257,-0.947863266551478,4.206660830311199,-0.2252475557449799,1.2657472734377568,2.6034158117050517,-1.019604048841438,-0.16113177748554827,1.8900097097013104 3643 Vitamin transport 8 10 2.5971033152885186 0.0094013641672365 Q8WTV0,Q9NPF0,P04062,P11166,O14678,P38435,P41440,Q9H2D1 Processes and pathways GO Biological process msigdb_gobp 420,524,449,514,301,80,213,286 301,449,514,2318,80,213,420,286,619,524 1.3877470096535027,0.9611422765478006,0.8134720365945656,-0.39908622494449625,2.5587558625495044,1.692943464578411,1.0339137070490352,1.4566081122737937,0.6818469365208409,0.8134720365945656 3643 Lumenal side of membrane 7 12 2.5898506647122503 0.0096017574854077 P30511,O15533,P51572,Q8TCT9,P10321,P27824,P27797 Localization GO Cellular component msigdb_gocc 6,329,397,364,48,118,539 329,1139,579,48,2663,880,539,118,6,397,1762,364 1.2832942009953483,0.17152746597699287,0.71968985939333,3.135226461008061,-0.5323126699925248,0.37199154172998977,0.776099228012361,2.285531889164803,4.673387267370069,1.105997161876891,-0.16113177748554827,1.1774078138827289 3643 transporter 22 66 2.5880586075260688 0.0096518557245921 O60830,Q99595,Q15012,Q9H2D1,P53985,Q8N8Q8,Q99567,Q8NFH4,O43772,Q9NR77,Q567V2,Q9Y584,Q15070,Q7Z3B4,P41440,Q9UJZ1,P61619,Q9HD45,Q8TEM1,Q92973,Q01650,P39210 Functions Panther Protein class panther_protein_class 0,2,398,286,409,285,673,541,663,42,171,308,200,509,213,609,363,120,249,125,376,505 1210,3371,3408,3571,2356,1792,825,1026,663,974,2910,0,2987,2089,2162,1800,505,213,1633,3191,2268,3002,2326,1491,409,1061,3192,1034,1259,363,981,376,2436,3359,398,200,171,3439,509,886,285,541,249,1857,1815,125,1126,2299,673,2,1165,1127,1606,923,286,941,2457,120,42,1277,3115,3458,609,308,1479,694 0.13076838476814698,-0.9956073764657654,-1.0436847151728275,-1.4409977440294737,-0.42111741427401633,-0.18244015934691968,0.4114378359281686,0.25237072765834473,0.6055828069993638,0.29246072303462184,-0.6452882514774274,5.89350676912575,-0.6909922588809689,-0.3116375849262432,-0.333399306791712,-0.18244015934691968,0.832089227524965,1.692943464578411,-0.09758260109774661,-0.8065769270037231,-0.37712313988404206,-0.6909922588809689,-0.39908622494449625,-0.013711595274741894,1.0700404706148139,0.23224335926748166,-0.8065769270037231,0.25237072765834473,0.11030317972784781,1.1774078138827289,0.29246072303462184,1.1417856605713883,-0.44321720897869366,-0.9716940090710073,1.105997161876891,1.8084952079083476,1.9546235974626718,-1.0678500734626066,0.832089227524965,0.37199154172998977,1.4566081122737937,0.776099228012361,1.592529825004484,-0.2038119362780547,-0.18244015934691968,2.239085653646518,0.1918220918189678,-0.37712313988404206,0.6055828069993638,5.347123193165582,0.17152746597699287,0.1918220918189678,-0.0765234222627171,0.3521891223123161,1.4566081122737937,0.33233340674752826,-0.44321720897869366,2.2700794880847806,3.2733225075135053,0.11030317972784781,-0.7369966820229626,-1.092100830903645,0.7007922534137548,1.3704358233118867,0.007105158915106008,0.5863945968863824 3643 Lipid transporter activity 11 28 2.582992986823695 0.0097947314012645 P17900,P11166,P30536,O14678,P08183,Q9H2C2,Q96GC9,Q9Y3B1,P61916,Q9H4L5,Q96AA3 Functions GO Molecular function msigdb_gomf 516,514,106,301,303,337,208,441,466,345,250 1727,301,2416,1176,303,514,516,2488,759,106,2318,1633,466,981,555,960,3504,250,208,1963,1774,1607,1470,337,345,1078,3210,441 -0.16113177748554827,1.3877470096535027,-0.44321720897869366,0.15117635458958095,1.3877470096535027,0.8134720365945656,0.8134720365945656,-0.465386116003162,0.4897054676751104,2.377631431346862,-0.39908622494449625,-0.09758260109774661,0.9244936801618757,0.29246072303462184,0.7573430676997512,0.31242405485919195,-1.1899723271023945,1.592529825004484,1.7261314689431049,-0.24674747021415624,-0.16113177748554827,-0.0765234222627171,0.007105158915106008,1.2657472734377568,1.2481603149029503,0.23224335926748166,-0.8065769270037231,0.99761495810321 3643 Organic acid transport 28 53 2.5824542508190675 0.0098100367710609 P23786,P30825,P11166,Q9UBX3,Q9UKG9,Q9H2D1,P53985,P14174,O43808,O43772,P31751,Q9Y3D6,O14678,Q9Y619,P08183,P55011,O60831,P50416,Q6P4A7,Q02978,Q7L0J3,P41440,Q96H78,P04083,Q15042,Q01650,P28288,O14745 Processes and pathways GO Biological process msigdb_gobp 255,771,514,144,403,286,409,150,779,663,550,173,301,694,303,678,434,709,725,79,863,213,216,484,741,376,759,876 301,876,2905,1176,663,779,434,1733,1883,1580,2480,3185,484,1445,3039,303,1400,514,150,255,759,771,2770,550,1887,2318,213,709,1491,409,678,1187,376,79,915,741,1301,3504,725,863,1233,2180,216,2583,3566,1014,286,1313,144,1434,403,173,694 1.3877470096535027,0.37199154172998977,-0.6452882514774274,0.15117635458958095,0.6055828069993638,0.4506749437853009,0.99761495810321,-0.16113177748554827,-0.2252475557449799,-0.0765234222627171,-0.465386116003162,-0.8065769270037231,0.8691865207095048,0.007105158915106008,-0.7139566269396745,1.3877470096535027,0.027862332156932304,0.8134720365945656,2.06645172244257,1.5756684289722063,0.4897054676751104,0.4702158680735321,-0.5772854996002308,0.7573430676997512,-0.2252475557449799,-0.39908622494449625,1.692943464578411,0.5478694768628188,-0.013711595274741894,1.0700404706148139,0.5863945968863824,0.15117635458958095,1.1417856605713883,2.5885562139486704,0.3521891223123161,0.5091440599781275,0.08978035873173802,-1.1899723271023945,0.5285319592869173,0.3917410017874763,0.13076838476814698,-0.333399306791712,1.6762968043598454,-0.48762464822389984,-1.390041774081608,0.2724430641772754,1.4566081122737937,0.08978035873173802,2.1296580535061174,0.027862332156932304,1.0880399570282553,1.9546235974626718,0.5863945968863824 3643 Peptidyl proline hydroxylation 6 7 2.581720033979095 0.0098309300218166 O75718,O15460,Q13162,P07237,Q32P28,P13674 Processes and pathways GO Biological process msigdb_gobp 99,194,72,41,12,47 194,99,41,47,72,12,411 1.824865383027324,2.423291779810149,3.2870083892475765,3.163027731650402,2.692012537294508,4.206660830311199,1.0700404706148139 3643 Sphingolipid metabolism overview 6 10 2.581261909046848 0.009843986739987 P27544,O95470,Q16739,Q16880,Q96G23,Q9NRA0 Processes and pathways WikiPathways msigdb_wp 5,209,282,246,55,257 611,1879,209,5,347,3358,282,246,55,257 0.6818469365208409,-0.2252475557449799,1.7095549611048153,4.73149126850177,1.2305331089305223,-0.9716940090710073,1.4566081122737937,1.592529825004484,2.980646976640566,1.5756684289722063 3643 Sphingolipid metabolism integrated pathway 6 10 2.581261909046848 0.009843986739987 P27544,O95470,Q16739,Q16880,Q96G23,Q9NRA0 Processes and pathways WikiPathways msigdb_wp 5,209,282,246,55,257 611,1879,209,5,347,3358,282,246,55,257 0.6818469365208409,-0.2252475557449799,1.7095549611048153,4.73149126850177,1.2305331089305223,-0.9716940090710073,1.4566081122737937,1.592529825004484,2.980646976640566,1.5756684289722063 3643 O acyltransferase activity 10 14 2.5800121404799627 0.0098796841792028 P23786,Q96N66,Q9HCL2,Q8NF37,Q8NCC3,P50416,Q92604,Q9UKG9,O15228,P35610 Functions GO Molecular function msigdb_gomf 255,389,3,557,358,709,461,403,465,783 465,255,2547,783,709,1459,358,557,461,389,1468,3,894,403 0.9244936801618757,1.5756684289722063,-0.48762464822389984,0.4506749437853009,0.5478694768628188,0.007105158915106008,1.1951570795527422,0.7573430676997512,0.9428400929877672,1.1239123190922105,0.007105158915106008,5.227283322630259,0.37199154172998977,1.0880399570282553 3643 primary active transporter 6 26 2.574448022264304 0.0100400170791976 O60888,Q15388,P16615,Q8N4H5,Q9BUN8,Q9NS69 Functions Panther Protein class panther_protein_class 222,201,267,56,122,63 222,1137,1106,697,976,1108,3040,2036,267,1553,1624,2107,2611,1117,201,1301,1193,725,56,2583,122,1313,1046,63,751,433 1.64289728589414,0.17152746597699287,0.1918220918189678,0.5671569209643074,0.29246072303462184,0.1918220918189678,-0.7139566269396745,-0.28994201948861137,1.5078566888617457,-0.055525473592154824,-0.09758260109774661,-0.3116375849262432,-0.5099333245444402,0.1918220918189678,1.8084952079083476,0.08978035873173802,0.15117635458958095,0.5285319592869173,2.9664513233824246,-0.48762464822389984,2.254597454452404,0.08978035873173802,0.25237072765834473,2.837587540785622,0.5091440599781275,1.0157859516403132 3643 Unfolded protein response upr 13 44 2.572089850553801 0.0101086653085333 Q9Y4L1,Q9Y5M8,O95070,Q13217,Q9NWM8,Q15084,O14653,Q14554,P43307,Q969H8,P14625,O14773,Q9HCU5 Processes and pathways Reactome Pathways msigdb_reactome 416,98,67,166,8,419,512,108,14,304,184,25,415 512,25,780,1696,67,3077,826,1355,2210,2812,184,1623,539,907,2491,14,1183,2044,1557,1222,2223,2865,166,2621,1494,108,3270,419,2738,1198,991,304,2696,415,2842,3386,2403,8,660,2468,2653,3071,416,98 0.8134720365945656,3.661517338984293,0.4506749437853009,-0.13988634815318823,2.794183911350097,-0.7369966820229626,0.4114378359281686,0.04856032582182117,-0.3552276637336356,-0.5998800653389513,1.8900097097013104,-0.09758260109774661,0.776099228012361,0.3521891223123161,-0.465386116003162,4.1449986542955966,0.15117635458958095,-0.28994201948861137,-0.055525473592154824,0.13076838476814698,-0.3552276637336356,-0.6225474635721432,1.9706953778300438,-0.5099333245444402,-0.013711595274741894,2.377631431346862,-0.8768601169890071,1.0339137070490352,-0.5547632158192415,0.15117635458958095,0.29246072303462184,1.3877470096535027,-0.5323126699925248,1.0519984666463416,-0.5998800653389513,-0.9956073764657654,-0.42111741427401633,4.352908051790398,0.6247218507870246,-0.44321720897869366,-0.5099333245444402,-0.7139566269396745,1.0519984666463416,2.438455053388052 3643 Mitochondrial complex i assembly model oxphos system 19 36 2.567619877217405 0.010239937639122 Q7L592,O75438,O75380,Q96CU9,P03886,O75306,O96000,Q9NW81,O95139,O95169,O43676,Q9Y6M9,O75489,O43674,O95168,O95167,Q8N183,Q9BUB7,P56556 Processes and pathways WikiPathways msigdb_wp 774,768,650,413,277,535,664,691,548,806,50,183,696,321,470,341,602,490,624 321,50,2358,535,650,768,696,548,341,470,806,1515,2155,664,277,953,3080,2605,3129,624,1498,774,865,602,1309,413,1535,2235,490,993,1017,691,2405,1508,1349,183 1.3008013122061457,3.107332731050088,-0.42111741427401633,0.776099228012361,0.6247218507870246,0.4702158680735321,0.5671569209643074,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.6055828069993638,1.4566081122737937,0.31242405485919195,-0.7369966820229626,-0.5099333245444402,-0.7601130162085916,0.6628536231131278,-0.013711595274741894,0.4702158680735321,0.3917410017874763,0.7007922534137548,0.08978035873173802,1.0519984666463416,-0.03458833609287247,-0.3552276637336356,0.8691865207095048,0.29246072303462184,0.2724430641772754,0.5863945968863824,-0.42111741427401633,-0.013711595274741894,0.06919953703395551,1.9062125107768622 3643 Microbody membrane 9 31 2.560373309659293 0.0104559778978776 P51648,Q9UKU0,Q15067,Q9BTZ2,Q9NR77,Q9Y3D6,O14678,Q9BY49,O15228 Localization GO Cellular component msigdb_gocc 32,96,387,139,42,173,301,81,465 1319,301,465,779,3152,1137,2480,1516,2852,2912,759,1887,505,666,1522,32,957,3378,387,988,1155,2012,1199,2884,1904,139,81,42,96,173,998 0.06919953703395551,1.3877470096535027,0.9244936801618757,0.4506749437853009,-0.7833062289105431,0.17152746597699287,-0.465386116003162,-0.03458833609287247,-0.6225474635721432,-0.6452882514774274,0.4897054676751104,-0.2252475557449799,0.832089227524965,0.6055828069993638,-0.03458833609287247,3.476322734521235,0.31242405485919195,-0.9956073764657654,1.1239123190922105,0.29246072303462184,0.17152746597699287,-0.2683121372291175,0.15117635458958095,-0.6225474635721432,-0.2252475557449799,2.1453820763492155,2.5587558625495044,3.2733225075135053,2.4535901140386045,1.9546235974626718,0.29246072303462184 3643 Abnormal csf protein level 7 16 2.5602477827126124 0.0104597556685055 Q9NZJ7,P07602,Q9NR77,P00403,P30038,Q16625,P03886 Drugs and Diseases Human Phenotype Ontology msigdb_hp 492,231,42,87,407,600,277 1545,1026,1885,87,277,953,231,1586,407,1032,1221,678,600,864,42,492 -0.055525473592154824,0.25237072765834473,-0.2252475557449799,2.5138506890054337,1.4566081122737937,0.31242405485919195,1.6261440706577892,-0.0765234222627171,1.0700404706148139,0.25237072765834473,0.13076838476814698,0.5863945968863824,0.7007922534137548,0.3917410017874763,3.2733225075135053,0.8691865207095048 3643 Oxidative phosphorylation 20 38 2.5464111926338253 0.0108836900815905 O75438,O75380,P03886,O75306,O96000,Q15904,O95139,Q9Y6M9,O75489,O43674,O95168,O95167,P06576,P24539,O75964,O00217,O75251,P56556,Q86Y39,O75787 Processes and pathways WikiPathways msigdb_wp 768,650,277,535,664,815,548,183,696,321,470,341,92,362,110,734,366,624,497,254 734,1875,321,2358,366,535,650,768,696,254,1138,110,548,341,470,806,1515,2155,664,1000,277,953,92,1932,3080,362,1517,2605,3463,3129,1258,931,624,815,1498,2280,497,183 0.5091440599781275,-0.2252475557449799,1.3008013122061457,-0.42111741427401633,1.1596174162013977,0.776099228012361,0.6247218507870246,0.4702158680735321,0.5671569209643074,1.5756684289722063,0.17152746597699287,2.3623540515125967,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.6055828069993638,0.2724430641772754,1.4566081122737937,0.31242405485919195,2.4535901140386045,-0.24674747021415624,-0.7369966820229626,1.1774078138827289,-0.03458833609287247,-0.5099333245444402,-1.1164377040450824,-0.7601130162085916,0.11030317972784781,0.33233340674752826,0.6628536231131278,0.4310823742970927,-0.013711595274741894,-0.37712313988404206,0.850660633843561,1.9062125107768622 3643 Respiratory electron transport chain 27 56 2.545827936603759 0.0109018910091207 O75438,P13073,O14949,P20674,O75380,P21912,P03886,O75306,O96000,O95139,P47985,O43676,Q9Y6M9,O75489,Q9UDW1,O43674,P04062,Q9H3K2,O43819,O95168,P00403,O95167,O14548,O75251,O00217,P56556,Q7KZN9 Processes and pathways GO Biological process msigdb_gobp 768,515,137,651,650,538,277,535,664,548,808,50,183,696,198,321,449,468,333,470,87,341,717,366,734,624,378 734,1875,717,137,321,50,2358,333,366,535,650,768,696,1733,548,341,470,806,1515,2155,664,1885,87,277,953,449,2662,1251,1357,2363,1252,515,3334,1056,1218,3080,651,538,2605,1405,2607,1182,808,3129,624,1118,2625,1498,2280,378,3567,3403,468,198,1434,183 0.5091440599781275,-0.2252475557449799,0.5285319592869173,2.1453820763492155,1.3008013122061457,3.107332731050088,-0.42111741427401633,1.2657472734377568,1.1596174162013977,0.776099228012361,0.6247218507870246,0.4702158680735321,0.5671569209643074,-0.16113177748554827,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.6055828069993638,-0.2252475557449799,2.5138506890054337,1.4566081122737937,0.31242405485919195,0.9611422765478006,-0.5323126699925248,0.11030317972784781,0.04856032582182117,-0.42111741427401633,0.11030317972784781,0.8134720365945656,-0.947863266551478,0.23224335926748166,0.13076838476814698,-0.7369966820229626,0.6247218507870246,0.776099228012361,-0.5099333245444402,0.027862332156932304,-0.5099333245444402,0.15117635458958095,0.4310823742970927,-0.7601130162085916,0.6628536231131278,0.1918220918189678,-0.5099333245444402,-0.013711595274741894,-0.37712313988404206,1.1417856605713883,-1.390041774081608,-1.019604048841438,0.9244936801618757,1.824865383027324,0.027862332156932304,1.9062125107768622 3643 Fad binding 6 11 2.5421713159102017 0.0110166161672702 Q15392,Q15067,O95831,Q9Y6N5,O15254,Q96HE7 Functions GO Molecular function msigdb_gomf 160,387,195,205,302,411 1319,302,195,1621,813,387,160,530,936,411,205 0.06919953703395551,1.3877470096535027,1.824865383027324,-0.09758260109774661,0.4310823742970927,1.1239123190922105,2.018717139797755,0.7948087934495096,0.33233340674752826,1.0700404706148139,1.7756527899161132 3643 Abnormal csf metabolite level 30 68 2.5258292966213336 0.0115425551135186 P13073,P11166,P30084,O75380,P30038,Q96CU9,P03886,O75306,O96000,O95169,O43676,Q9Y6M9,Q8NCW5,Q8NI60,O75489,O95831,P08559,Q8IUX1,O43819,Q9NWS8,P00403,Q8N183,Q9HC21,O75251,O00217,P56556,Q7KZN9,Q86Y39,P0DJ07,P39210 Drugs and Diseases Human Phenotype Ontology msigdb_hp 515,514,528,650,407,413,277,535,664,806,50,183,317,446,696,195,451,865,333,607,87,602,619,366,734,624,378,497,756,505 734,1084,1875,50,2358,333,366,535,650,696,2154,806,2155,195,664,1885,87,1000,277,953,451,756,514,515,3080,2605,407,528,1405,1519,505,3510,1521,3129,2673,2045,2428,624,1747,1092,3201,2280,859,2226,378,2390,497,865,602,317,446,1309,1961,1273,413,1683,1240,3258,2235,619,1017,2792,607,2405,1508,1349,1542,183 0.5091440599781275,0.21206060116262693,-0.2252475557449799,3.107332731050088,-0.42111741427401633,1.2657472734377568,1.1596174162013977,0.776099228012361,0.6247218507870246,0.5671569209643074,-0.333399306791712,0.4310823742970927,-0.333399306791712,1.824865383027324,0.6055828069993638,-0.2252475557449799,2.5138506890054337,0.2724430641772754,1.4566081122737937,0.31242405485919195,0.9611422765478006,0.4897054676751104,0.8134720365945656,0.8134720365945656,-0.7369966820229626,-0.5099333245444402,1.0700404706148139,0.7948087934495096,0.027862332156932304,-0.03458833609287247,0.832089227524965,-1.2146610216914933,-0.03458833609287247,-0.7601130162085916,-0.5323126699925248,-0.28994201948861137,-0.44321720897869366,0.6628536231131278,-0.16113177748554827,0.21206060116262693,-0.8065769270037231,-0.37712313988404206,0.3917410017874763,-0.3552276637336356,1.1417856605713883,-0.42111741427401633,0.850660633843561,0.3917410017874763,0.7007922534137548,1.318268819891666,0.9794004819604001,0.08978035873173802,-0.24674747021415624,0.11030317972784781,1.0519984666463416,-0.11870343366061006,0.13076838476814698,-0.8533532449353657,-0.3552276637336356,0.6818469365208409,0.2724430641772754,-0.5772854996002308,0.7007922534137548,-0.42111741427401633,-0.013711595274741894,0.06919953703395551,-0.03458833609287247,1.9062125107768622 3643 Metallopeptidase activity 18 44 2.524954290963526 0.0115713338648901 Q9UIQ6,Q969V3,Q9NQH7,Q5JRX3,P52888,P78536,Q9NQW7,Q9Y4W6,Q6P179,P55786,Q9BYT8,Q92905,O43847,Q7Z2K6,O75844,Q9NZ08,P22695,Q7L5N1 Functions GO Molecular function msigdb_gomf 230,421,591,35,325,226,38,620,103,138,141,77,578,147,217,127,563,227 899,900,1439,578,879,217,3530,1442,3606,1663,2483,1401,563,3430,652,955,2551,2324,325,854,138,226,1093,35,103,2281,227,147,77,421,2580,938,841,866,1905,141,3614,1431,591,38,2024,127,230,620 0.3521891223123161,0.3521891223123161,0.007105158915106008,0.71968985939333,0.37199154172998977,1.659614804060893,-1.2643087218937006,0.007105158915106008,-1.8360748989715658,-0.11870343366061006,-0.465386116003162,0.027862332156932304,0.7385400373905193,-1.0678500734626066,0.6247218507870246,0.31242405485919195,-0.48762464822389984,-0.39908622494449625,1.3008013122061457,0.3917410017874763,2.1453820763492155,1.64289728589414,0.21206060116262693,3.4495350664729076,2.3928800946790516,-0.37712313988404206,1.64289728589414,2.0981172248521958,2.6034158117050517,1.0339137070490352,-0.48762464822389984,0.33233340674752826,0.4114378359281686,0.3917410017874763,-0.2252475557449799,2.1296580535061174,-1.9455372097525145,0.027862332156932304,0.71968985939333,3.314313786509081,-0.2683121372291175,2.239085653646518,1.64289728589414,0.6818469365208409 3643 Anion transmembrane transporter activity 26 57 2.5226577686154967 0.0116471690694086 P45880,P0CG08,P30825,P11166,Q9Y277,Q9UBX3,Q8TB61,P53985,Q9H2D1,O43808,P21796,Q9C0H2,Q9Y619,Q14728,Q86VD7,P55011,Q6KCM7,P51797,P04920,P12235,Q02978,P41440,Q96S66,Q9HC21,Q01650,O00400 Functions GO Molecular function msigdb_gomf 261,638,771,514,661,144,410,409,286,779,278,689,694,814,177,678,701,191,450,581,79,213,219,619,376,123 3216,123,876,1176,1026,779,1733,1580,450,1581,1400,638,514,581,904,278,771,2318,213,261,1942,191,2219,1491,409,678,376,79,814,1893,1301,960,701,3439,1269,3504,177,1233,410,2180,2583,3566,219,1127,1014,689,286,2141,1313,619,144,1434,661,694,1287,3305,846 -0.829925724951396,2.239085653646518,0.37199154172998977,0.15117635458958095,0.25237072765834473,0.4506749437853009,-0.16113177748554827,-0.0765234222627171,0.9611422765478006,-0.0765234222627171,0.027862332156932304,0.6438120248840904,0.8134720365945656,0.71968985939333,0.3521891223123161,1.4566081122737937,0.4702158680735321,-0.39908622494449625,1.692943464578411,1.5418361654019872,-0.24674747021415624,1.8412017569470738,-0.3552276637336356,-0.013711595274741894,1.0700404706148139,0.5863945968863824,1.1417856605713883,2.5885562139486704,0.4310823742970927,-0.2252475557449799,0.08978035873173802,0.31242405485919195,0.5671569209643074,-1.0678500734626066,0.11030317972784781,-1.1899723271023945,1.9223823204371768,0.13076838476814698,1.0700404706148139,-0.333399306791712,-0.48762464822389984,-1.390041774081608,1.659614804060893,0.1918220918189678,0.2724430641772754,0.5863945968863824,1.4566081122737937,-0.3116375849262432,0.08978035873173802,0.6818469365208409,2.1296580535061174,0.027862332156932304,0.6247218507870246,0.5863945968863824,0.11030317972784781,-0.900446979133231,0.4114378359281686 3643 Organelle membrane contact site 11 20 2.5203427359261994 0.0117240614792366 Q9Y320,Q96N66,Q14849,Q15388,P51572,Q96S66,O95772,P27824,Q96TC7,O43865,Q5XKP0 Localization GO Cellular component msigdb_gocc 448,389,555,201,397,219,394,118,380,404,670 1318,1727,404,3152,394,697,118,397,555,201,670,1463,2634,389,219,380,2300,3404,1244,448 0.06919953703395551,-0.16113177748554827,1.0700404706148139,-0.7833062289105431,1.105997161876891,0.5671569209643074,2.285531889164803,1.105997161876891,0.7573430676997512,1.8084952079083476,0.6055828069993638,0.007105158915106008,-0.5099333245444402,1.1239123190922105,1.659614804060893,1.1417856605713883,-0.37712313988404206,-1.019604048841438,0.13076838476814698,0.9794004819604001 3643 Cation transmembrane transporter activity 34 85 2.5188583501349773 0.0117736010642504 Q9UM00,P07355,Q9HD20,P13073,P30825,P16615,Q96RD7,Q8N4V1,P20674,O43808,O43772,Q9Y619,P47985,Q8NEW0,Q86VD7,P55011,Q9UDW1,P12235,P00403,O14548,P06576,Q9HC21,Q70HW3,Q9H0U3,P61619,P24539,O75964,Q9Y487,Q13423,Q7KZN9,Q8N1S5,P06756,Q01650,O00400 Functions GO Molecular function msigdb_gomf 259,770,136,515,771,267,399,274,651,779,663,694,808,49,177,678,198,581,87,717,92,619,357,491,363,362,110,502,114,378,247,622,376,123 123,717,663,779,1138,110,1028,1885,87,1000,976,1108,1581,92,622,770,3079,1400,1357,1252,581,515,267,1932,1553,651,2855,3310,1624,362,1517,771,881,1141,1059,1588,808,3463,1942,678,1258,931,1222,363,1117,2222,3464,376,114,1893,1301,960,962,357,378,177,934,247,274,1159,49,2640,1162,3633,3514,2583,3566,399,1127,491,1313,942,619,136,1314,2592,198,1870,2899,259,502,1512,694,1287,846 2.239085653646518,0.5285319592869173,0.6055828069993638,0.4506749437853009,0.17152746597699287,2.3623540515125967,0.25237072765834473,-0.2252475557449799,2.5138506890054337,0.2724430641772754,0.29246072303462184,0.1918220918189678,-0.0765234222627171,2.4535901140386045,0.6628536231131278,0.4702158680735321,-0.7369966820229626,0.027862332156932304,0.04856032582182117,0.11030317972784781,0.71968985939333,0.8134720365945656,1.5078566888617457,-0.24674747021415624,-0.055525473592154824,0.6247218507870246,-0.6225474635721432,-0.9241144775154201,-0.09758260109774661,1.1774078138827289,-0.03458833609287247,0.4702158680735321,0.37199154172998977,0.17152746597699287,0.23224335926748166,-0.0765234222627171,0.4310823742970927,-1.1164377040450824,-0.24674747021415624,0.5863945968863824,0.11030317972784781,0.33233340674752826,0.13076838476814698,1.1774078138827289,0.1918220918189678,-0.3552276637336356,-1.1164377040450824,1.1417856605713883,2.331712628995581,-0.2252475557449799,0.08978035873173802,0.31242405485919195,0.31242405485919195,1.1951570795527422,1.1417856605713883,1.9223823204371768,0.33233340674752826,1.592529825004484,1.473728476771492,0.17152746597699287,3.12129119884825,-0.5099333245444402,0.17152746597699287,-3.0906760096205748,-1.2146610216914933,-0.48762464822389984,-1.390041774081608,1.105997161876891,0.1918220918189678,0.8691865207095048,0.08978035873173802,0.33233340674752826,0.6818469365208409,2.1610753620574217,0.08978035873173802,-0.48762464822389984,1.824865383027324,-0.2038119362780547,-0.6225474635721432,1.5587706046077934,0.850660633843561,-0.013711595274741894,0.5863945968863824,0.11030317972784781,0.4114378359281686 3643 Limb ataxia 9 26 2.518566948452858 0.011783348016318 Q8IV08,P07196,P04062,Q9NR77,Q9BUK6,O75298,P41440,O14773,Q14108 Drugs and Diseases Human Phenotype Ontology msigdb_hp 65,291,449,42,45,546,213,25,444 3278,2415,25,1353,546,449,2808,291,3159,2954,2158,1405,2215,213,1221,1093,1226,444,724,65,45,2839,42,1246,2651,620 -0.900446979133231,-0.44321720897869366,3.661517338984293,0.04856032582182117,0.7573430676997512,0.9611422765478006,-0.5998800653389513,1.4222538872246275,-0.7833062289105431,-0.6681029929832263,-0.333399306791712,0.027862332156932304,-0.3552276637336356,1.692943464578411,0.13076838476814698,0.21206060116262693,0.13076838476814698,0.9794004819604001,0.5285319592869173,2.808677111591547,3.204557850940264,-0.5998800653389513,3.2733225075135053,0.13076838476814698,-0.5099333245444402,0.6818469365208409 3643 Organic anion transmembrane transporter activity 19 37 2.5182863199600853 0.0117927413853082 O14745,P30825,P11166,Q9UBX3,Q8TB61,P53985,Q9H2D1,O43808,Q9Y619,Q14728,Q86VD7,Q6KCM7,Q9Y6M7,P12235,Q02978,P41440,Q9HC21,Q01650,O00400 Functions GO Molecular function msigdb_gomf 876,771,514,144,410,409,286,779,694,814,177,701,846,581,79,213,619,376,123 123,876,1176,779,1733,1580,1581,1400,514,581,904,771,2318,213,1491,409,376,79,814,1301,701,1269,3504,177,1233,410,2583,3566,1127,1014,286,1313,619,144,1434,694,846 2.239085653646518,0.37199154172998977,0.15117635458958095,0.4506749437853009,-0.16113177748554827,-0.0765234222627171,-0.0765234222627171,0.027862332156932304,0.8134720365945656,0.71968985939333,0.3521891223123161,0.4702158680735321,-0.39908622494449625,1.692943464578411,-0.013711595274741894,1.0700404706148139,1.1417856605713883,2.5885562139486704,0.4310823742970927,0.08978035873173802,0.5671569209643074,0.11030317972784781,-1.1899723271023945,1.9223823204371768,0.13076838476814698,1.0700404706148139,-0.48762464822389984,-1.390041774081608,0.1918220918189678,0.2724430641772754,1.4566081122737937,0.08978035873173802,0.6818469365208409,2.1296580535061174,0.027862332156932304,0.5863945968863824,0.4114378359281686 3643 Abnormal brainstem mri signal intensity 13 25 2.5154549358287994 0.011887887381496 O75489,O96000,O95831,O75251,O43676,O75380,Q9Y6M9,P56556,Q86Y39,Q8N183,Q96CU9,P03886,O75306 Drugs and Diseases Human Phenotype Ontology msigdb_hp 696,664,195,366,50,650,183,624,497,602,413,277,535 734,50,366,535,650,696,195,664,277,3080,2605,1032,3129,624,497,865,602,1309,1861,413,2235,1017,2405,1508,183 0.5091440599781275,3.107332731050088,1.1596174162013977,0.776099228012361,0.6247218507870246,0.5671569209643074,1.824865383027324,0.6055828069993638,1.4566081122737937,-0.7369966820229626,-0.5099333245444402,0.25237072765834473,-0.7601130162085916,0.6628536231131278,0.850660633843561,0.3917410017874763,0.7007922534137548,0.08978035873173802,-0.2038119362780547,1.0519984666463416,-0.3552276637336356,0.2724430641772754,-0.42111741427401633,-0.013711595274741894,1.9062125107768622 3643 Thioredoxin-like superfamily [IPR036249] 22 55 2.513862909967058 0.0119416843474882 Q8IXB1,O43396,P30040,Q8NBS9,Q9H7Z7,Q15084,P07237,Q9H3N1,Q9H1E5,O15217,P13667,Q8NBF2,Q96J42,Q9Y320,Q13162,O43819,Q96JJ7,Q9Y2G8,P30101,Q14554,O95881,Q9BS26 Sequence InterPro Superfamily interpro_homologous_superfamily 129,383,386,402,158,419,41,297,181,179,443,316,319,448,72,333,350,354,352,108,237,251 3216,1876,179,383,2358,2655,333,718,3485,237,41,443,3080,3595,3083,3311,386,2547,2915,1058,352,1799,3431,3417,1892,72,108,419,2056,1231,989,3440,129,1068,316,402,746,1764,1903,319,350,1606,251,491,181,3575,968,297,158,1170,3304,354,3029,448,3305 -0.829925724951396,-0.2252475557449799,1.9062125107768622,1.1239123190922105,-0.42111741427401633,-0.5323126699925248,1.2657472734377568,0.5285319592869173,-1.1653727114302805,1.6093549777202447,3.2870083892475765,0.9794004819604001,-0.7369966820229626,-1.6752169966089951,-0.7369966820229626,-0.9241144775154201,1.1239123190922105,-0.48762464822389984,-0.6452882514774274,0.23224335926748166,1.2128654372087189,-0.18244015934691968,-1.0678500734626066,-1.0436847151728275,-0.2252475557449799,2.692012537294508,2.377631431346862,1.0339137070490352,-0.28994201948861137,0.13076838476814698,0.29246072303462184,-1.0678500734626066,2.223543950079106,0.23224335926748166,1.318268819891666,1.0880399570282553,0.5091440599781275,-0.16113177748554827,-0.2252475557449799,1.318268819891666,1.2305331089305223,-0.0765234222627171,1.592529825004484,0.8691865207095048,1.9062125107768622,-1.4409977440294737,0.31242405485919195,1.4050196301598754,2.034660375542446,0.17152746597699287,-0.900446979133231,1.2128654372087189,-0.6909922588809689,0.9794004819604001,-0.900446979133231 3643 Er to golgi transport vesicle membrane 8 27 2.5094734386835182 0.0120911308464575 P30511,P49755,Q15437,O14653,P04439,P10321,P49257,Q8NI22 Localization GO Cellular component msigdb_gocc 6,225,617,512,579,48,238,22 512,755,1834,2602,1179,1696,1619,3332,1139,579,48,6,238,225,2372,1034,1299,3169,1707,617,643,22,995,971,1789,873,2082 0.8134720365945656,0.4897054676751104,-0.2038119362780547,-0.5099333245444402,0.15117635458958095,-0.13988634815318823,-0.09758260109774661,-0.947863266551478,0.17152746597699287,0.71968985939333,3.135226461008061,4.673387267370069,1.6093549777202447,1.64289728589414,-0.42111741427401633,0.25237072765834473,0.08978035873173802,-0.7833062289105431,-0.13988634815318823,0.6818469365208409,0.6438120248840904,3.7655729970606435,0.29246072303462184,0.31242405485919195,-0.16113177748554827,0.3917410017874763,-0.28994201948861137 3643 Disproportionate short stature 9 27 2.5074943390668296 0.0121590529207618 Q15392,Q9Y366,O75718,Q14696,P34059,Q32P28,O15228,Q7RTS9,Q14739 Drugs and Diseases Human Phenotype Ontology msigdb_hp 160,525,99,263,551,12,465,343,281 1319,465,3427,99,2805,1216,1886,2667,551,1091,1941,263,281,2826,160,12,1231,1813,343,1234,1375,2133,890,633,1280,2645,525 0.06919953703395551,0.9244936801618757,-1.0678500734626066,2.423291779810149,-0.5998800653389513,0.13076838476814698,-0.2252475557449799,-0.5323126699925248,0.7573430676997512,0.21206060116262693,-0.24674747021415624,1.5418361654019872,1.4566081122737937,-0.5998800653389513,2.018717139797755,4.206660830311199,0.13076838476814698,-0.18244015934691968,1.2481603149029503,0.13076838476814698,0.04856032582182117,-0.3116375849262432,0.37199154172998977,0.6628536231131278,0.11030317972784781,-0.5099333245444402,0.8134720365945656 3643 Dioxygenase activity 7 21 2.507021231231285 0.0121753398229929 Q12797,O15460,P16435,P07237,Q32P28,Q6PK18,P13674 Functions GO Molecular function msigdb_gomf 481,194,71,41,12,271,47 822,2414,194,493,41,47,71,613,481,12,3099,1956,271,2631,1530,2135,1909,3274,3472,1172,1391 0.4114378359281686,-0.44321720897869366,1.824865383027324,0.850660633843561,3.2870083892475765,3.163027731650402,2.7213338218562386,0.6818469365208409,0.8876671508686171,4.206660830311199,-0.7369966820229626,-0.24674747021415624,1.4908112708908634,-0.5099333245444402,-0.03458833609287247,-0.3116375849262432,-0.2252475557449799,-0.8768601169890071,-1.1164377040450824,0.17152746597699287,0.04856032582182117 3643 Aerobic respiration 40 98 2.504383063587017 0.0122665146129874 O75438,P13073,O14949,P20674,O75380,Q96I99,P21912,P14406,P03886,O75306,O96000,O95139,O75323,P47985,O43676,Q9Y6M9,P22695,O75489,Q9BSK2,Q9UDW1,O43674,Q15070,P08559,O75874,Q9H3K2,O95168,P00403,Q9UJZ1,O95167,P36404,O14548,P06576,P48735,P24539,O75964,O00217,O75251,Q13423,P56556,Q7KZN9 Processes and pathways GO Biological process msigdb_gobp 768,515,137,651,650,791,538,28,277,535,664,548,547,808,50,183,563,696,327,198,321,200,451,457,468,470,87,609,341,218,717,92,97,362,110,734,366,114,624,378 734,1875,717,137,321,50,2358,1693,366,535,547,650,2714,768,696,457,1138,110,548,341,470,806,1515,2155,664,1885,87,1000,277,953,1251,92,1837,451,1357,2363,2813,1252,1664,515,28,1401,1056,1218,1932,3080,651,1989,538,563,362,1517,1294,2605,2818,2957,1405,881,827,218,1141,2426,3189,3510,1668,808,3463,97,3129,3087,1144,2045,2552,1258,931,624,2331,114,200,2386,1498,2280,2125,378,3469,791,1684,3567,2585,2072,1427,327,468,2594,3302,198,609,183 0.5091440599781275,-0.2252475557449799,0.5285319592869173,2.1453820763492155,1.3008013122061457,3.107332731050088,-0.42111741427401633,-0.13988634815318823,1.1596174162013977,0.776099228012361,0.7573430676997512,0.6247218507870246,-0.5547632158192415,0.4702158680735321,0.5671569209643074,0.9428400929877672,0.17152746597699287,2.3623540515125967,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.6055828069993638,-0.2252475557449799,2.5138506890054337,0.2724430641772754,1.4566081122737937,0.31242405485919195,0.11030317972784781,2.4535901140386045,-0.2038119362780547,0.9611422765478006,0.04856032582182117,-0.42111741427401633,-0.5998800653389513,0.11030317972784781,-0.11870343366061006,0.8134720365945656,3.5429255537908872,0.027862332156932304,0.23224335926748166,0.13076838476814698,-0.24674747021415624,-0.7369966820229626,0.6247218507870246,-0.2683121372291175,0.776099228012361,0.7385400373905193,1.1774078138827289,-0.03458833609287247,0.08978035873173802,-0.5099333245444402,-0.5998800653389513,-0.6681029929832263,0.027862332156932304,0.37199154172998977,0.4114378359281686,1.659614804060893,0.17152746597699287,-0.44321720897869366,-0.8065769270037231,-1.2146610216914933,-0.11870343366061006,0.4310823742970927,-1.1164377040450824,2.438455053388052,-0.7601130162085916,-0.7369966820229626,0.17152746597699287,-0.28994201948861137,-0.48762464822389984,0.11030317972784781,0.33233340674752826,0.6628536231131278,-0.39908622494449625,2.331712628995581,1.8084952079083476,-0.42111741427401633,-0.013711595274741894,-0.37712313988404206,-0.3116375849262432,1.1417856605713883,-1.1164377040450824,0.4506749437853009,-0.11870343366061006,-1.390041774081608,-0.48762464822389984,-0.28994201948861137,0.027862332156932304,1.3008013122061457,0.9244936801618757,-0.48762464822389984,-0.900446979133231,1.824865383027324,0.7007922534137548,1.9062125107768622 3643 Extracellular matrix organization 14 34 2.5031860652820184 0.0123080818663658 P78536,O75718,P07942,P05067,O15460,Q02809,P07237,Q32P28,P11047,P13674,O14936,Q92542,O60568,P35613 Processes and pathways Reactome Pathways msigdb_reactome 226,99,196,385,194,613,41,12,580,47,206,531,493,279 822,206,194,2246,493,99,2092,385,1445,622,41,3159,196,580,977,47,1839,3336,3563,2667,279,909,1450,226,613,3574,830,1118,12,919,531,1967,2310,3032 0.4114378359281686,1.742673161727919,1.824865383027324,-0.37712313988404206,0.850660633843561,2.423291779810149,-0.3116375849262432,1.1239123190922105,0.007105158915106008,0.6628536231131278,3.2870083892475765,-0.7833062289105431,1.824865383027324,0.71968985939333,0.29246072303462184,3.163027731650402,-0.2038119362780547,-0.947863266551478,-1.390041774081608,-0.5323126699925248,1.4566081122737937,0.3521891223123161,0.007105158915106008,1.64289728589414,0.6818469365208409,-1.4409977440294737,0.4114378359281686,0.1918220918189678,4.206660830311199,0.3521891223123161,0.7948087934495096,-0.24674747021415624,-0.37712313988404206,-0.6909922588809689 3643 Slc mediated transmembrane transport 11 27 2.4960667592856427 0.0125578964949935 Q70HW3,P04920,P11166,Q9UBX3,Q8NEW0,Q8TB61,P53985,Q01650,P36404,P35613,O00400 Processes and pathways Reactome Pathways msigdb_reactome 357,450,514,144,49,410,409,376,218,279,123 123,450,1581,1400,514,581,904,2160,771,279,218,409,678,376,1893,1301,987,3504,357,49,410,3566,1127,144,2899,1287,846 2.239085653646518,0.9611422765478006,-0.0765234222627171,0.027862332156932304,0.8134720365945656,0.71968985939333,0.3521891223123161,-0.333399306791712,0.4702158680735321,1.4566081122737937,1.659614804060893,1.0700404706148139,0.5863945968863824,1.1417856605713883,-0.2252475557449799,0.08978035873173802,0.29246072303462184,-1.1899723271023945,1.1951570795527422,3.12129119884825,1.0700404706148139,-1.390041774081608,0.1918220918189678,2.1296580535061174,-0.6225474635721432,0.11030317972784781,0.4114378359281686 3643 Abnormal glycosylation 9 23 2.492648972278265 0.0126794128854268 Q9BT22,Q9H0U3,Q8TCJ2,Q8N511,P51571,Q9Y487,P46977,Q96AA3,O75787 Drugs and Diseases Human Phenotype Ontology msigdb_hp 161,491,336,13,400,502,152,250,254 2801,2602,254,2718,3266,1059,3249,1588,1030,152,400,1225,1750,815,13,336,250,1770,161,491,2145,574,502 -0.5998800653389513,-0.5099333245444402,1.5756684289722063,-0.5547632158192415,-0.8768601169890071,0.23224335926748166,-0.8533532449353657,-0.0765234222627171,0.25237072765834473,2.06645172244257,1.0880399570282553,0.13076838476814698,-0.16113177748554827,0.4310823742970927,4.206660830311199,1.2657472734377568,1.592529825004484,-0.16113177748554827,2.018717139797755,0.8691865207095048,-0.3116375849262432,0.7385400373905193,0.850660633843561 3643 Outer mitochondrial membrane protein complex 8 15 2.4895798700181397 0.0127894178541758 Q13505,Q15388,Q9Y512,Q9NX63,Q8N4H5,Q5XKP0,Q16891,Q9NS69 Localization GO Cellular component msigdb_gocc 519,201,575,544,56,670,700,63 1695,1106,697,2720,519,201,700,670,1010,56,1966,63,1278,544,575 -0.13988634815318823,0.1918220918189678,0.5671569209643074,-0.5547632158192415,0.8134720365945656,1.8084952079083476,0.5671569209643074,0.6055828069993638,0.2724430641772754,2.9664513233824246,-0.24674747021415624,2.837587540785622,0.11030317972784781,0.776099228012361,0.7385400373905193 3643 Complex i biogenesis 19 37 2.481862444983909 0.0130697717462082 Q7L592,O75438,O75380,P03886,O75306,O96000,O95139,O95169,O43676,Q9Y6M9,O75489,O43674,O95168,O95167,Q8N183,O75251,O00217,P56556,Q86Y39 Processes and pathways Reactome Pathways msigdb_reactome 774,768,650,277,535,664,548,806,50,183,696,321,470,341,602,366,734,624,497 734,321,50,2358,366,535,650,768,696,548,341,470,806,1515,2155,664,277,953,3080,2605,3129,624,1498,2280,774,497,865,602,1309,1535,2235,993,1017,2405,1508,1349,183 0.5091440599781275,1.3008013122061457,3.107332731050088,-0.42111741427401633,1.1596174162013977,0.776099228012361,0.6247218507870246,0.4702158680735321,0.5671569209643074,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,0.6055828069993638,1.4566081122737937,0.31242405485919195,-0.7369966820229626,-0.5099333245444402,-0.7601130162085916,0.6628536231131278,-0.013711595274741894,-0.37712313988404206,0.4702158680735321,0.850660633843561,0.3917410017874763,0.7007922534137548,0.08978035873173802,-0.03458833609287247,-0.3552276637336356,0.29246072303462184,0.2724430641772754,-0.42111741427401633,-0.013711595274741894,0.06919953703395551,1.9062125107768622 3643 Antigen processing and presentation 9 27 2.472412904582856 0.0134204410452696 Q9UIQ6,P30101,P30511,P04062,Q6P179,O15533,P10321,P27797,Q9NZ08 Processes and pathways GO Biological process msigdb_gobp 230,352,6,449,103,329,48,539,127 2982,3408,2906,329,1139,449,579,48,1401,1585,539,352,6,1255,1260,1453,829,2682,1367,103,1466,1100,3404,3579,127,230,873 -0.6909922588809689,-1.0436847151728275,-0.6452882514774274,1.2832942009953483,0.17152746597699287,0.9611422765478006,0.71968985939333,3.135226461008061,0.027862332156932304,-0.0765234222627171,0.776099228012361,1.2128654372087189,4.673387267370069,0.11030317972784781,0.11030317972784781,0.007105158915106008,0.4114378359281686,-0.5323126699925248,0.04856032582182117,2.3928800946790516,0.007105158915106008,0.21206060116262693,-1.019604048841438,-1.4666211442411048,2.239085653646518,1.64289728589414,0.3917410017874763 3643 Protein insertion into er membrane 6 14 2.466372776245847 0.0136489205325753 P61619,Q15629,Q8N4V1,Q96A33,Q8N766,Q9NPA0 Processes and pathways GO Biological process msigdb_gobp 363,112,274,188,349,391 2357,1026,1484,1631,363,1332,112,833,585,274,349,188,391,2077 -0.42111741427401633,0.25237072765834473,-0.013711595274741894,-0.09758260109774661,1.1774078138827289,0.06919953703395551,2.3470478270665613,0.4114378359281686,0.71968985939333,1.473728476771492,1.2305331089305223,1.8575044941143102,1.1239123190922105,-0.28994201948861137 3643 Intrinsic component of golgi membrane 8 13 2.4595833595198853 0.0139098390621719 Q9Y282,O95070,O43505,Q969X5,Q9Y5Z9,Q5BJH7,Q8TB61,Q8N2H4 Localization GO Cellular component msigdb_gocc 162,67,662,729,576,146,410,348 1395,803,662,67,1117,1750,146,989,348,410,729,162,576 0.027862332156932304,0.4310823742970927,0.6055828069993638,2.794183911350097,0.1918220918189678,-0.16113177748554827,2.0981172248521958,0.29246072303462184,1.2305331089305223,1.0700404706148139,0.5285319592869173,2.0027419959879986,0.7385400373905193 3643 Alcohol binding 9 18 2.4493545193348365 0.0143112509864504 O75477,P45880,P30536,O95772,P61916,O94905,Q9H4L5,Q14108,P21796 Functions GO Molecular function msigdb_gomf 322,261,106,394,466,334,345,444,278 3262,2416,2801,322,334,394,3079,278,2316,106,783,261,466,444,555,1607,1470,345 -0.8768601169890071,-0.44321720897869366,-0.5998800653389513,1.3008013122061457,1.2657472734377568,1.105997161876891,-0.7369966820229626,1.4566081122737937,-0.39908622494449625,2.377631431346862,0.4506749437853009,1.5418361654019872,0.9244936801618757,0.9794004819604001,0.7573430676997512,-0.0765234222627171,0.007105158915106008,1.2481603149029503 3643 Translation of sars cov 2 structural proteins 8 18 2.4472316335877142 0.0143958287791539 P14314,Q13724,P04843,P04844,Q10472,P27824,P46977,Q14697 Processes and pathways Reactome Pathways msigdb_reactome 324,356,384,395,210,118,152,445 384,395,324,1057,118,1030,152,956,2044,1742,3544,210,356,445,1951,2070,3207,491 1.1239123190922105,1.105997161876891,1.3008013122061457,0.23224335926748166,2.285531889164803,0.25237072765834473,2.06645172244257,0.31242405485919195,-0.28994201948861137,-0.16113177748554827,-1.2892692909305767,1.7095549611048153,1.1951570795527422,0.9794004819604001,-0.24674747021415624,-0.28994201948861137,-0.8065769270037231,0.8691865207095048 3643 Clumsiness 8 18 2.446132125661709 0.0144398072760336 O75503,Q15067,Q9NZJ7,P07602,O00165,Q9NR77,O43819,O14773 Drugs and Diseases Human Phenotype Ontology msigdb_hp 479,387,492,231,382,42,333,25 382,2415,25,2203,1026,333,479,1984,231,1405,3358,387,2830,2226,603,42,492,2463 1.1239123190922105,-0.44321720897869366,3.661517338984293,-0.3552276637336356,0.25237072765834473,1.2657472734377568,0.8876671508686171,-0.2683121372291175,1.6261440706577892,0.027862332156932304,-0.9716940090710073,1.1239123190922105,-0.5998800653389513,-0.3552276637336356,0.7007922534137548,3.2733225075135053,0.8691865207095048,-0.44321720897869366 3643 Areflexia of lower limbs 15 23 2.441811711125514 0.0146137663005563 Q15041,Q15067,O75477,O60313,P07196,Q9H6K4,Q13217,Q9NR77,Q16637,P12235,Q96RL7,Q7LG56,Q15120,Q96RR1,O75787 Drugs and Diseases Human Phenotype Ontology msigdb_hp 915,387,322,847,291,264,166,42,742,581,532,864,494,603,254 847,322,254,999,902,291,581,2370,1255,1221,1033,2552,3569,166,915,387,494,742,864,532,603,264,42 0.3917410017874763,1.3008013122061457,1.5756684289722063,0.2724430641772754,0.3521891223123161,1.4222538872246275,0.71968985939333,-0.42111741427401633,0.11030317972784781,0.13076838476814698,0.25237072765834473,-0.48762464822389984,-1.4154715764183334,1.9706953778300438,0.3521891223123161,1.1239123190922105,0.850660633843561,0.5091440599781275,0.3917410017874763,0.7948087934495096,0.7007922534137548,1.5418361654019872,3.2733225075135053 3643 The citric acid tca cycle and respiratory electron transport 46 110 2.438544962752453 0.0147465240560447 Q7L592,O75438,P13073,O14949,P20674,O75380,Q96I99,Q8N8Q8,P53985,P21912,P35613,P21796,P03886,O75306,O96000,O95139,P47985,O43676,Q9Y6M9,P22695,O75489,Q9UDW1,Q8NCN5,O43674,P08559,O43819,Q15118,O95168,P00403,O95167,O75880,Q8N183,P06576,O14548,P48735,P24539,O75964,Q9P0J1,O00217,P48163,O75251,Q13423,P56556,Q86Y39,Q15120,P23368 Processes and pathways Reactome Pathways msigdb_reactome 774,768,515,137,651,650,791,285,409,538,279,278,277,535,664,548,808,50,183,563,696,198,713,321,451,333,599,470,87,341,718,602,92,717,97,362,110,241,734,760,366,114,624,497,494,119 734,1084,1875,717,137,321,50,2358,2655,333,1693,366,535,650,2714,768,696,718,1138,110,548,341,470,806,1515,2155,1580,664,3391,1885,87,1000,277,953,92,3534,1837,451,1357,2363,1583,2813,1252,1664,515,3334,1056,1218,1932,3080,651,278,538,563,119,362,1517,2605,1405,881,279,1141,2426,2607,3510,1521,808,3463,760,97,3129,3087,1144,2045,409,1258,931,624,2331,1634,1146,114,599,494,2625,1498,2280,2692,774,497,865,602,285,713,1309,1683,791,2585,1535,2235,993,1101,1017,2405,1508,1349,241,3302,198,183 0.5091440599781275,0.21206060116262693,-0.2252475557449799,0.5285319592869173,2.1453820763492155,1.3008013122061457,3.107332731050088,-0.42111741427401633,-0.5323126699925248,1.2657472734377568,-0.13988634815318823,1.1596174162013977,0.776099228012361,0.6247218507870246,-0.5547632158192415,0.4702158680735321,0.5671569209643074,0.5285319592869173,0.17152746597699287,2.3623540515125967,0.7573430676997512,1.2481603149029503,0.9061027846832771,0.4310823742970927,-0.03458833609287247,-0.333399306791712,-0.0765234222627171,0.6055828069993638,-1.019604048841438,-0.2252475557449799,2.5138506890054337,0.2724430641772754,1.4566081122737937,0.31242405485919195,2.4535901140386045,-1.2643087218937006,-0.2038119362780547,0.9611422765478006,0.04856032582182117,-0.42111741427401633,-0.0765234222627171,-0.5998800653389513,0.11030317972784781,-0.11870343366061006,0.8134720365945656,-0.947863266551478,0.23224335926748166,0.13076838476814698,-0.24674747021415624,-0.7369966820229626,0.6247218507870246,1.4566081122737937,0.776099228012361,0.7385400373905193,2.2700794880847806,1.1774078138827289,-0.03458833609287247,-0.5099333245444402,0.027862332156932304,0.37199154172998977,1.4566081122737937,0.17152746597699287,-0.44321720897869366,-0.5099333245444402,-1.2146610216914933,-0.03458833609287247,0.4310823742970927,-1.1164377040450824,0.4897054676751104,2.438455053388052,-0.7601130162085916,-0.7369966820229626,0.17152746597699287,-0.28994201948861137,1.0700404706148139,0.11030317972784781,0.33233340674752826,0.6628536231131278,-0.39908622494449625,-0.09758260109774661,0.17152746597699287,2.331712628995581,0.7007922534137548,0.850660633843561,-0.5099333245444402,-0.013711595274741894,-0.37712313988404206,-0.5323126699925248,0.4702158680735321,0.850660633843561,0.3917410017874763,0.7007922534137548,1.4566081122737937,0.5478694768628188,0.08978035873173802,-0.11870343366061006,0.4506749437853009,-0.48762464822389984,-0.03458833609287247,-0.3552276637336356,0.29246072303462184,0.21206060116262693,0.2724430641772754,-0.42111741427401633,-0.013711595274741894,0.06919953703395551,1.6093549777202447,-0.900446979133231,1.824865383027324,1.9062125107768622 3643 Calcium ion binding 23 93 2.4340134947202685 0.0149324383653299 Q9NPF0,Q9NWM8,P16615,O43852,Q14257,Q8NI22,P27797,Q8NF37,Q9Y680,P80303,Q9UM22,P14625,Q96A33,P14314,Q02818,Q96AY3,Q15293,O14967,Q12797,Q9BRK5,P04083,Q9Y4G8,P27824 Functions GO Molecular function msigdb_gomf 524,8,267,16,20,22,539,557,39,43,51,184,188,324,74,75,203,469,481,105,484,503,118 1318,469,1026,778,16,2206,545,2986,2602,706,1733,1486,1028,3632,484,3428,2092,770,3159,3079,1930,3374,977,2717,3605,324,184,267,3336,1089,1292,978,539,118,3248,2160,2161,1736,1520,1630,1182,1490,3001,1004,2676,1452,640,980,43,74,3574,2559,3315,481,1300,2622,20,3492,3093,203,1096,701,1269,1373,1760,1643,786,557,22,1375,188,75,3021,1501,1905,1906,792,105,2018,1965,1776,1912,524,8,692,1721,971,1921,1434,51,1831,503,39 0.06919953703395551,0.9061027846832771,0.25237072765834473,0.4506749437853009,4.095354306912875,-0.3552276637336356,0.7573430676997512,-0.6909922588809689,-0.5099333245444402,0.5478694768628188,-0.16113177748554827,-0.013711595274741894,0.25237072765834473,-2.863473284482365,0.8691865207095048,-1.0678500734626066,-0.3116375849262432,0.4702158680735321,-0.7833062289105431,-0.7369966820229626,-0.24674747021415624,-0.9956073764657654,0.29246072303462184,-0.5547632158192415,-1.808991775160554,1.3008013122061457,1.8900097097013104,1.5078566888617457,-0.947863266551478,0.21206060116262693,0.08978035873173802,0.29246072303462184,0.776099228012361,2.285531889164803,-0.8533532449353657,-0.333399306791712,-0.333399306791712,-0.16113177748554827,-0.03458833609287247,-0.09758260109774661,0.15117635458958095,-0.013711595274741894,-0.6909922588809689,0.2724430641772754,-0.5323126699925248,0.007105158915106008,0.6438120248840904,0.29246072303462184,3.2321311079528603,2.633054429019238,-1.4409977440294737,-0.48762464822389984,-0.9241144775154201,0.8876671508686171,0.08978035873173802,-0.5099333245444402,3.8042718536546554,-1.1653727114302805,-0.7369966820229626,1.792091065872174,0.21206060116262693,0.5671569209643074,0.11030317972784781,0.04856032582182117,-0.16113177748554827,-0.09758260109774661,0.4506749437853009,0.7573430676997512,3.7655729970606435,0.04856032582182117,1.8575044941143102,2.633054429019238,-0.6909922588809689,-0.013711595274741894,-0.2252475557449799,-0.2252475557449799,0.4506749437853009,2.3928800946790516,-0.2683121372291175,-0.24674747021415624,-0.16113177748554827,-0.2252475557449799,0.8134720365945656,4.352908051790398,0.5863945968863824,-0.13988634815318823,0.31242405485919195,-0.2252475557449799,0.027862332156932304,3.037189084386894,-0.18244015934691968,0.850660633843561,3.314313786509081 3643 Transition metal ion transport 6 18 2.4330625869559346 0.0149717127377329 O75027,O15173,Q9HD20,Q8NEW0,Q8N4V1,Q8N1S5 Processes and pathways GO Biological process msigdb_gobp 260,37,136,49,274,247 37,260,3606,1255,1117,2557,2111,2378,1893,1527,247,274,49,1313,942,136,447,2899 3.314313786509081,1.5418361654019872,-1.8360748989715658,0.11030317972784781,0.1918220918189678,-0.48762464822389984,-0.3116375849262432,-0.42111741427401633,-0.2252475557449799,-0.03458833609287247,1.592529825004484,1.473728476771492,3.12129119884825,0.08978035873173802,0.33233340674752826,2.1610753620574217,0.9794004819604001,-0.6225474635721432 3643 Mitochondrial calcium ion transport 12 19 2.42040360246804 0.0155032891810629 Q8IYU8,Q9Y4W6,P45880,Q99623,Q9UJZ1,Q9Y277,Q9NWR8,Q9H300,Q9H4I9,O75439,Q96TA2,P21796 Processes and pathways Reactome Pathways msigdb_reactome 786,620,261,167,609,661,659,795,78,879,841,278 879,1028,278,2425,261,1093,786,1159,965,2063,841,167,1906,795,78,659,609,661,620 0.37199154172998977,0.25237072765834473,1.4566081122737937,-0.44321720897869366,1.5418361654019872,0.21206060116262693,0.4506749437853009,0.17152746597699287,0.31242405485919195,-0.28994201948861137,0.4114378359281686,1.9706953778300438,-0.2252475557449799,0.4506749437853009,2.6034158117050517,0.6247218507870246,0.7007922534137548,0.6247218507870246,0.6818469365208409 3643 Calcium ion import 8 17 2.417374887171213 0.0156329071892431 Q9Y4W6,P14373,P16615,O14936,Q9H4I9,O75844,P21796,Q9NRA0 Processes and pathways GO Biological process msigdb_gobp 620,639,267,206,78,217,278,257 206,217,639,267,1112,278,1624,1627,3464,786,1159,965,1906,78,257,659,620 1.742673161727919,1.659614804060893,0.6438120248840904,1.5078566888617457,0.1918220918189678,1.4566081122737937,-0.09758260109774661,-0.09758260109774661,-1.1164377040450824,0.4506749437853009,0.17152746597699287,0.31242405485919195,-0.2252475557449799,2.6034158117050517,1.5756684289722063,0.6247218507870246,0.6818469365208409 3643 Inorganic anion transport 13 32 2.415507083595775 0.0157133168472789 P45880,Q9C0H2,P04920,P0CG08,P30536,Q9Y277,P08183,Q9UBX3,Q02978,Q9UHG3,Q96S66,P21796,P51797 Processes and pathways GO Biological process msigdb_gobp 261,689,450,638,106,661,303,144,79,84,219,278,191 3216,1176,1026,450,303,638,278,106,2318,261,1942,191,2219,1061,678,2222,79,1893,960,3439,1233,2180,219,689,2644,2141,144,84,661,1287,3305,846 -0.829925724951396,0.15117635458958095,0.25237072765834473,0.9611422765478006,1.3877470096535027,0.6438120248840904,1.4566081122737937,2.377631431346862,-0.39908622494449625,1.5418361654019872,-0.24674747021415624,1.8412017569470738,-0.3552276637336356,0.23224335926748166,0.5863945968863824,-0.3552276637336356,2.5885562139486704,-0.2252475557449799,0.31242405485919195,-1.0678500734626066,0.13076838476814698,-0.333399306791712,1.659614804060893,0.5863945968863824,-0.5099333245444402,-0.3116375849262432,2.1296580535061174,2.5587558625495044,0.6247218507870246,0.11030317972784781,-0.900446979133231,0.4114378359281686 3643