term overlap setsize score pval edge type subtype subtype_key edge_idxs ann_idxs ann_vals sig_size Organelle inner membrane 84 224 5.138735543050792 2.765933358979813e-07 Q567V2,O60830,Q96CU9,Q99720,Q13505,O76031,O43772,Q9UDW1,P14406,O43676,Q9H2D1,Q99595,O95831,Q70HW3,O95202,O95168,O75844,Q13423,Q96DV4,Q9BRJ2,Q9BSK2,Q9BYC9,Q14739,Q9Y619,Q9H2W6,Q7KZN9,O75306,Q9BQT8,Q9UBX3,Q9UDX5,O75964,Q5SNT2,Q9Y6C9,Q9H061,Q9Y2R0,P53701,Q6UXV4,Q9P032,P49748,Q10713,P15954,O43819,O75027,O95299,P12236,P23786,P82914,Q16134,Q9P0M9,Q92552,Q96EY7,P22570,P82933,Q9UH99,P00403,Q8NC56,O75746,Q14728,Q96BW9,O94901,P17152,Q69YU5,Q8NBN7,Q15070,O14925,P53007,Q6P1L8,Q14197,P50402,Q5T9A4,P82930,O14949,Q9BTV4,Q9NYK5,P13073,Q96A35,Q9Y6M9,Q16795,P22695,Q9H1E5,Q9UJS0,Q6P4A7,Q5T653,O75600 Localization GO Cellular component msigdb_gocc 2,8,9,13,15,508,26,42,44,46,50,56,58,64,555,554,68,77,621,622,623,625,91,92,627,95,97,109,110,111,106,118,128,126,138,135,141,687,148,661,648,640,641,642,647,650,659,663,185,723,724,700,712,225,699,221,243,246,264,258,299,305,335,330,321,325,353,351,348,372,368,362,402,409,388,431,438,426,417,499,502,488,486,473 3175,1790,321,362,853,46,26,640,1461,8,641,1975,1068,97,998,1069,1887,1888,473,243,68,2335,1223,106,508,258,554,1379,555,642,859,58,800,699,1074,2488,2734,1159,1544,1633,1988,2178,2618,1161,647,2970,388,44,2868,648,299,1637,2561,2082,2562,1315,700,417,2870,2263,650,1163,2682,2625,745,1083,2829,2089,2000,1556,2831,1084,870,702,940,808,2354,1087,148,2091,2633,348,943,751,2635,325,135,1248,1477,1170,1562,2360,1484,2014,752,2100,1407,659,368,712,1655,952,2905,661,1661,1568,1013,2792,77,15,351,246,91,330,663,2379,426,1330,1499,1414,2,2453,118,486,372,1841,305,1672,2517,353,488,1264,2208,141,64,95,1422,2212,1109,2798,2914,2215,1681,335,221,1949,1683,2980,2460,723,1200,431,264,9,621,724,1686,1039,974,56,3008,13,2309,907,109,622,1353,623,836,402,1206,1958,625,976,1522,1696,1124,126,499,50,2051,627,1437,1699,1358,1865,1962,2401,2919,841,1866,3068,1612,776,912,1529,2149,409,983,687,1288,185,110,42,111,225,502,1706,780,1451,138,1531,923,2891,1140,1297,1788,1535,1455,2725,1142,92,128,438 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3193 Endoplasmic reticulum 109 464 4.918472834151591 8.722201884802582e-07 Q9H6V9,Q14108,P30519,P80303,Q99720,P43307,Q9BQE5,Q9UQB8,P24390,Q5BJF2,O60725,Q03518,Q06136,P09601,P30536,Q02818,Q9HD20,Q9BZF3,Q96G23,O75844,Q15392,P13674,Q8TDW0,Q16880,Q15629,P35610,Q7L0J3,P10619,Q14739,Q9Y680,Q12959,Q9UMX5,Q13555,P42858,O75845,Q16850,O75503,Q9UKR5,P48449,Q9NZ08,O43731,Q9BRK5,Q15800,O95864,Q14257,P62266,Q99797,Q9UBV2,Q9BRR6,Q9Y282,Q9BUN8,Q9H488,Q8TCJ2,P06493,P04035,Q9H2M9,P04439,O15460,Q96HY6,Q8NC56,Q92643,Q2TAA5,O95487,Q9BV10,P46776,Q32P28,Q86UE4,Q7Z2K6,P84157,Q9H3N1,P04062,Q96LJ7,Q9HBH5,Q92604,P57088,Q86XL3,Q86YN1,Q8TBX8,Q9Y3E0,Q10471,O43852,O14653,Q9Y3A6,Q08AM6,Q02878,P50402,Q6ZXV5,Q15042,P35613,Q9BTV4,Q9UM00,Q9Y4P3,O75718,Q13190,Q9NUQ7,Q53GQ0,P61009,P46977,Q96A57,Q5J8M3,Q9P2W9,Q96RL7,O15258,Q99442,Q8TED0,P42345,A0FGR8,O00767,Q13557 Localization GO Cellular component msigdb_gocc 1,6,7,12,13,16,19,21,22,23,29,30,31,35,53,55,59,62,65,68,75,80,81,86,85,84,88,90,91,101,103,112,108,107,105,115,116,127,121,133,139,147,150,153,157,162,166,168,175,186,184,191,199,195,194,209,202,201,223,221,222,217,213,235,227,248,251,250,245,270,259,288,292,286,278,283,309,310,316,328,322,319,361,350,349,348,373,371,366,402,410,411,385,393,434,427,423,419,459,454,467,462,441,496,494,477,470,471,480 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3193 Transporter activity 44 161 4.749820422597441 2.0359736274677687e-06 Q96ES6,O60830,P04062,Q8NBU5,Q99808,Q9Y6M7,O43772,Q03518,Q8IXU6,P21796,Q99797,Q9NS69,Q9UDW1,P51798,O43676,Q9H2D1,Q6N075,Q8WTV0,P30536,Q99595,Q9HD20,Q9BZF3,Q15388,Q70HW3,P45880,Q9Y487,Q9C0H2,Q13423,O14925,Q8TDW0,P53007,Q7L0J3,Q9HC07,Q9Y619,Q7KZN9,O75306,P53985,Q9BQT8,Q9UBX3,O75964,Q93050,O75746,P08183,Q14728 Functions GO Molecular function msigdb_gomf 5,8,259,263,289,25,26,30,36,37,166,41,42,170,46,50,172,51,53,56,59,62,304,64,69,73,76,77,321,81,325,88,89,92,95,97,102,109,110,106,252,243,120,246 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3193 Organelle subcompartment 93 357 4.618209881565709 3.8706465734783535e-06 Q9NQC3,Q14108,P30519,Q99720,P43307,Q9BQE5,P24390,Q5BJF2,O60725,Q03518,Q06136,P09601,Q9HD20,Q9BZF3,Q96G23,Q969E2,O75844,Q15392,Q8TDW0,Q15629,P35610,Q9HC07,Q14739,Q16706,O00461,Q12959,Q13555,O75845,Q16850,Q9UKR5,P48449,Q9NZ08,Q12893,O43731,Q15800,O95864,Q9UBV2,Q9BRR6,Q9Y282,Q9BUN8,Q8TCJ2,P06493,P04035,Q9H2M9,P04439,Q96HY6,Q92643,Q2TAA5,O00443,O95487,O15126,Q9BV10,Q86UE4,Q7Z2K6,Q9H3N1,P04062,Q9HBH5,Q92604,P57088,Q86XL3,Q86YN1,Q10471,Q9UID3,Q96L58,Q8WWQ0,O43852,P56377,O14653,P53367,Q9Y3A6,P50402,Q15042,P35613,Q9UM00,Q9Y4P3,O14828,Q13190,Q53GQ0,P61009,P46977,P20645,Q96A57,Q5J8M3,Q8IWJ2,Q9P2W9,Q96RL7,Q99442,P42345,A0FGR8,O00767,Q13557,Q15437,Q9BWS9 Localization GO Cellular component msigdb_gocc 537,6,7,13,16,19,22,23,29,30,31,35,59,62,65,67,68,75,81,85,84,89,91,98,100,103,108,105,115,127,121,133,136,139,150,153,168,175,186,184,199,195,194,209,202,223,222,217,211,213,212,235,251,250,270,259,292,286,278,283,309,328,339,337,336,322,327,319,326,361,348,371,366,410,411,384,393,427,423,419,416,459,454,456,467,462,496,477,470,471,480,483,535 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3193 Nuclear outer membrane endoplasmic reticulum membrane network 75 285 4.548141223487254 5.412181376174274e-06 Q9NQC3,Q9H3N1,Q9NZ08,Q14108,P30519,Q9UM00,Q9Y4P3,O43731,Q99720,P43307,Q9BQE5,P24390,Q5BJF2,Q15800,O95864,Q9HBH5,Q13190,Q92604,O60725,Q03518,Q06136,P57088,P09601,Q86XL3,Q9UBV2,Q86YN1,Q53GQ0,P61009,Q9BRR6,P46977,Q9Y282,Q9BUN8,Q5J8M3,Q9HD20,Q9BZF3,Q10471,Q96G23,Q8TCJ2,O75844,Q9P2W9,P06493,P04035,Q96RL7,Q9H2M9,Q15392,O43852,O14653,P04439,Q8TDW0,Q9Y3A6,Q15629,P35610,Q96HY6,Q99442,Q92643,Q14739,Q2TAA5,O95487,Q12959,Q9BV10,P50402,P35613,P42345,A0FGR8,Q13555,O00767,O75845,Q13557,Q16850,Q86UE4,Q7Z2K6,Q15042,Q15437,Q9UKR5,P48449 Localization GO Cellular component msigdb_gocc 537,270,133,6,7,410,411,139,13,16,19,22,23,150,153,292,393,286,29,30,31,278,35,283,168,309,427,423,175,419,186,184,454,59,62,328,65,199,68,467,195,194,462,209,75,322,319,202,81,361,85,84,223,496,222,91,217,213,103,235,348,366,477,470,108,471,105,480,115,251,250,371,483,127,121 470,1061,1877,1219,2925,2164,471,2990,319,928,1972,2548,2330,3131,851,996,2332,2671,139,322,2607,1716,2672,29,1067,796,1540,68,105,507,856,1226,2612,2171,2554,1979,2775,1889,799,1228,213,698,859,153,2733,645,2968,194,202,860,1157,195,2995,931,1382,1898,35,1077,2259,935,1805,1637,2622,1388,2624,22,1164,2495,937,2827,1639,7,2998,1998,2087,1472,84,366,1237,868,939,477,870,16,419,1906,121,2902,2270,874,3115,1090,1242,348,2006,2435,601,3085,1560,2274,2437,1649,2570,2094,278,2750,1822,708,423,812,948,1093,1401,2874,562,2359,2360,1173,2197,2098,1916,1008,1744,1096,30,3125,31,607,328,1922,567,103,1012,393,108,480,1102,6,882,1573,1259,2282,91,1260,818,2283,371,2286,1931,3088,885,75,2701,483,85,758,150,1936,3164,115,217,427,23,454,1667,1026,2290,666,889,1029,1187,668,2382,250,1266,251,892,1505,283,309,2299,893,1193,2649,615,824,2126,1948,1680,1111,1112,1426,670,1113,970,1114,199,2128,1513,2708,81,1848,671,1849,826,827,286,222,2523,2219,2390,1117,1769,971,65,2302,902,223,1687,1203,462,2395,771,496,772,13,1040,19,175,2138,1859,624,1122,184,1958,235,2529,2885,2918,1605,62,3066,1356,209,270,2887,1609,292,842,59,583,685,537,1613,2597,846,1131,133,3014,1965,916,1446,467,2470,984,631,2058,168,918,127,2989,410,2478,186,1625,1058,361,547,1967,411,2406,1215,3168,2326,925 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3193 Transmembrane transport 35 211 4.452613043577018 8.483155280680776e-06 Q9UHG3,Q96ES6,O60830,Q9Y6M7,O43772,Q03518,Q8IXU6,P21796,Q99797,Q9NS69,Q9UDW1,P51798,Q9H2D1,Q8WTV0,Q99595,O95831,Q9HD20,Q70HW3,O75844,P45880,Q9C0H2,Q13423,Q8TDW0,Q15629,Q7L0J3,Q9HC07,Q9Y619,Q7KZN9,P53985,Q12959,Q9BQT8,Q9UBX3,P42858,O75964,P08183 Processes and pathways GO Biological process msigdb_gobp 4,5,8,25,26,30,36,37,166,41,42,170,50,51,56,58,59,64,68,69,76,77,81,85,88,89,92,95,102,103,109,110,107,106,120 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3193 Transporters 85 359 4.430086343413247 9.419536635801862e-06 Q14108,Q99720,P24390,Q5BJF2,Q9Y6M7,O43772,Q03518,Q8IXU6,O60637,Q9H2D1,Q8WTV0,Q5VW38,Q9HD20,Q70HW3,Q9NR77,Q969E2,O75844,P45880,Q9C0H2,P07602,Q8TDW0,Q15629,Q9HC07,Q9Y619,O95782,P53985,Q12959,Q9BQT8,Q9UBX3,Q13555,Q9Y6C9,Q9H061,P08183,Q9BTX1,Q9BRK5,Q92544,P81605,Q9NZJ7,Q9UBV2,P51798,Q8NE00,P46934,Q6N075,Q9BUN8,P14635,Q8TCJ2,P06493,P04035,P04439,O14786,Q9UH99,O15126,Q93050,O75746,Q9H3N1,O94901,Q99808,P57088,Q6UW68,O60443,Q15070,P53007,Q8TAD4,Q9Y4P1,Q6ZXV5,P35613,O60831,Q9UM00,P13073,O14828,Q13190,P46977,P20645,O60784,Q8TEX9,Q96A57,Q5J8M3,Q96RL7,P57105,O15258,Q99442,Q8IYB3,Q9UJS0,Q6P4A7,A0FGR8 Functions Protein Atlas Protein class protein_atlas_protein_class 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3193 Transport 102 483 4.325108389081527 1.524568817368177e-05 Q96ES6,O60830,Q96CU9,A6NIH7,Q99720,Q13432,Q13505,Q9BQE5,P24390,Q9Y6M7,O43772,Q03518,Q8IXU6,P21796,Q9NS69,Q9UDW1,O43676,Q9H2D1,Q99595,Q9HD20,Q9BZF3,Q70HW3,Q969E2,P45880,Q9Y487,Q9C0H2,Q8TDW0,Q15629,O43169,Q7L0J3,Q9Y619,O43396,O95782,O75306,O00461,P53985,Q9BQT8,Q9UBX3,O75964,Q9Y6C9,P08183,Q9BTX1,Q12893,O43731,O95864,Q9NZJ7,P51798,Q6N075,Q9Y282,Q9BUN8,Q96FZ7,P46379,P63167,O95487,O15126,Q96AX1,Q8N4H5,Q93050,O75746,Q14728,Q9H3N1,Q99808,Q9Y3E0,Q15388,Q13769,Q9UID3,P56377,O14653,O14925,P53007,Q9Y3A6,Q9BTX7,Q8TAD4,Q9Y4P1,Q9BY77,P31751,O60831,O14949,Q9UM00,O14828,Q13190,Q9Y6M9,Q15286,Q16795,P22695,P20645,O60784,Q8TEX9,Q8IWJ2,Q9Y277,Q9H269,Q9P2W9,Q96RL7,A0AVF1,Q99442,Q7Z3U7,Q9H1E5,Q9UJS0,Q6P4A7,A0FGR8,O15504,P22626 Processes and pathways Protein Atlas Biological process protein_atlas_biological_process 5,8,9,11,13,14,15,19,22,25,26,30,36,37,41,42,46,50,56,59,62,64,67,69,73,76,81,85,87,88,92,93,94,97,100,102,109,110,106,128,120,132,136,139,153,167,170,172,186,184,189,197,198,213,212,233,231,252,243,246,270,289,316,304,302,339,327,319,321,325,361,357,354,382,380,365,363,362,410,384,393,438,425,426,417,416,413,457,456,469,464,467,462,439,496,489,499,502,488,470,472,476 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3193 Mitochondrial envelope 105 305 4.03847434033794 5.37999771710318e-05 Q567V2,Q9NVH0,Q9NZ45,O60830,Q96CU9,Q13505,O76031,O43772,Q13057,P09601,Q16611,P21796,Q9NS69,Q8IWA4,Q9UDW1,P14406,O43676,Q9H2D1,P30536,Q99595,O95831,Q70HW3,O95202,O95168,P45880,Q13423,Q96DV4,Q9BRJ2,Q9BSK2,O43169,Q9BYC9,Q9H2W6,Q9Y619,Q9NQG6,Q7KZN9,O75306,Q9BQT8,Q9UBX3,Q9UDX5,O75964,P78537,Q9Y6C9,Q9H061,Q96AY3,Q9GZY8,Q9Y2R0,P53701,Q6UXV4,Q9H078,Q9P032,P49748,Q10713,P15954,Q9HCL2,O43819,O75027,O95299,P00387,P12236,O00165,P23786,Q9NZJ7,P82914,Q16134,Q9P0M9,Q92552,Q96EY7,Q02218,P22570,P82933,O15228,O14786,O95573,Q8N4H5,O75746,Q96BW9,Q8NBU5,Q9BUK6,P17152,Q69YU5,Q15388,Q8NBN7,Q5VT66,Q15070,O14925,P53007,Q6P1L8,Q14197,Q5T9A4,P82930,O14949,Q9NYK5,P13073,Q96A35,Q9Y6M9,Q16795,P22695,Q9Y277,Q96RL7,P57105,Q9UJS0,Q6P4A7,Q5T653,P42345,O75600 Localization GO Cellular component msigdb_gocc 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3193 Ion transmembrane transporter activity 25 99 3.7343738567386704 0.0001881827810787 Q96ES6,Q9Y6M7,O43772,P21796,Q9UDW1,P51798,Q9H2D1,Q6N075,Q9HD20,Q70HW3,P45880,Q9Y487,Q9C0H2,Q13423,Q8TDW0,Q9HC07,Q9Y619,Q7KZN9,P53985,Q9BQT8,Q9UBX3,O75964,Q93050,O75746,Q14728 Functions GO Molecular function msigdb_gomf 5,25,26,37,42,170,50,172,59,64,69,73,76,77,81,89,92,95,102,109,110,106,252,243,246 2950,2991,694,26,638,243,1223,106,555,699,2255,3167,1074,2488,2677,2929,1464,1159,3111,2178,2778,1161,647,388,1805,2181,2082,2182,2739,37,1163,2682,1083,1811,2000,2745,2630,1733,69,808,2354,3171,170,325,102,877,1170,1562,1479,2874,2959,1655,1657,952,77,246,1929,884,1580,172,2517,1187,488,667,64,95,1683,354,970,81,2711,252,5,1039,771,289,109,2529,1043,76,3066,50,1698,1358,1865,89,841,59,845,110,42,2854,502,410,469,73,92,2407,25 -0.9519864382224174,-1.0421318380239888,0.41618190889414125,3.481516904512842,0.4540235095844826,0.9638462735845957,0.10581674080916348,1.6044026869650967,0.529103559661836,0.41618190889414125,-0.3856868930458746,-2.1841159131798,0.1847155783283068,-0.5133061398194652,-0.6427799465527326,-0.9072118013025617,-0.014168302611951702,0.1453758906367192,-1.3638313793686463,-0.34356283749264765,-0.7301162059779877,0.1453758906367192,0.4540235095844826,0.7134182805889118,-0.17716618352898394,-0.34356283749264765,-0.30164793499149467,-0.34356283749264765,-0.6863465232630938,2.8902828388919057,0.1453758906367192,-0.6427799465527326,0.1847155783283068,-0.17716618352898394,-0.25994298419798034,-0.6863465232630938,-0.5994172002524207,-0.13609598281271182,2.1365684786427637,0.33988043265628903,-0.4280193129695504,-2.3344564924882825,1.2061148609413,0.8217925949426864,1.6688607961699844,0.30141428148632216,0.1453758906367192,-0.05459618476215373,-0.014168302611951702,-0.8182620339173361,-0.9519864382224174,-0.09523903258909394,-0.09523903258909394,0.26273353937402294,1.9836200003720745,0.9638462735845957,-0.21844879395768765,0.30141428148632216,-0.05459618476215373,1.2061148609413,-0.5133061398194652,0.1453758906367192,0.603398739242378,0.4540235095844826,2.2867598270374043,1.7645826062622836,-0.09523903258909394,0.7858464474140958,0.26273353937402294,1.9216366583397482,-0.6427799465527326,0.9638462735845957,5.917318571154168,0.22383486656935098,0.3781352496108558,0.8931610038007228,1.6044026869650967,-0.5133061398194652,0.22383486656935098,2.0144370273869896,-1.178830334389834,2.579393242759746,-0.09523903258909394,0.06603905308700285,-0.17716618352898394,1.8277698868878607,0.33988043265628903,2.4343271247364595,0.33988043265628903,1.6044026869650967,2.834566999031995,-0.7740882787487618,0.603398739242378,0.7134182805889118,0.640258997817798,2.106203804691737,1.7962380654131864,-0.4280193129695504,3.5592823972272063 3193 Mitochondrial protein containing complex 43 145 3.7038598554522415 0.0002123435988041 Q567V2,O60830,Q96CU9,Q9NYK5,Q6UXV4,Q13505,P13073,O76031,P53597,P15954,O95299,Q96A35,P12236,P21796,Q9Y6M9,Q9NS69,Q8IWA4,Q9UDW1,P14406,Q96RQ3,O43676,Q16795,P22695,Q9P0M9,O00330,Q99595,Q15388,O95168,O14925,Q96DV4,Q9BRJ2,Q9BYC9,Q9H2W6,Q6P1L8,Q14197,O75306,Q5T653,Q8N4H5,P21953,O75964,P54098,P82930,O14949 Localization GO Cellular component msigdb_gocc 2,8,9,409,141,15,388,508,511,648,642,431,647,37,438,41,574,42,44,578,46,426,417,185,412,56,304,554,321,621,622,625,627,353,351,97,486,231,595,106,114,368,362 3175,412,1369,1790,321,362,1883,46,1537,8,1068,97,998,1069,1888,1223,106,508,1309,554,1379,642,800,699,1074,2488,1897,1159,1544,1804,1988,1990,2178,1992,1161,647,388,44,2868,648,2561,2082,37,1315,595,417,1163,2682,2625,1165,745,1083,2089,2000,2831,1084,808,2354,1087,2091,1243,943,944,751,2635,511,114,1477,1170,1562,2014,2100,1407,659,368,712,1568,2792,15,351,304,2379,426,1330,1499,1414,2,486,1841,353,141,1334,1422,2212,574,1340,1109,231,2215,1681,1683,2128,723,431,9,621,2393,1686,578,56,3008,2397,2309,622,1958,625,976,1522,1124,627,1962,2919,2655,1612,41,776,1529,2149,409,983,1288,185,42,780,1451,1531,923,2891,1140,1297,1535,1455,2725,1142,438 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3193 Mitochondria 115 404 3.697443286937773 0.0002177818533517 Q9NUJ1,Q9NVH0,Q9NZ45,O60830,Q96CU9,Q13505,Q8WVV9,Q8TC07,O76031,P53597,O43772,Q9NS69,Q8IWA4,Q96RQ3,Q9H2D1,Q16740,Q9H019,Q99595,O95831,Q8TAE8,Q70HW3,O95168,O95202,P28070,P45880,Q13423,P13674,Q16880,Q969Z0,Q96DV4,Q9BYC9,Q9H2W6,Q9H7Z7,Q9NQG6,Q7KZN9,O75306,Q9UBX3,Q9UDX5,P21953,O75964,P36957,P54098,P60903,Q9Y6C9,Q96AY3,Q15120,Q9GZY8,Q9Y2R0,P53701,Q6UXV4,Q9P032,P23378,P49748,Q5JTZ9,Q10713,Q9HCL2,O43819,O75027,O95299,Q5JRX3,P12236,O00165,P21399,Q99797,P23786,Q14168,Q9NXF1,P30837,Q8N4H5,O75648,Q8NBU5,Q9GZT3,Q9NUL7,Q8N3Z3,P83111,Q7LGA3,Q6DKI1,P17152,Q69YU5,Q15388,Q8NBN7,Q5VT66,Q15070,O14734,O14925,Q96SZ6,Q6P1L8,Q14197,P11498,P05165,Q5T9A4,Q8NCM8,P82930,O14949,Q96SY0,Q9BXW7,Q9NSE4,Q9NYK5,P13073,Q9HBK9,Q9Y2X7,Q9Y6M9,Q16795,P22695,O00330,Q96C01,Q9Y277,Q9BZ95,Q3SXM5,P57105,Q8TD30,Q9UJS0,Q6P4A7,Q5T653,O75600 Localization Protein Atlas Subcellular protein_atlas_subcellular_location_all 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3193 Intrinsic component of organelle membrane 42 124 3.639277597545671 0.0002734039483105 Q9BTV4,Q9UM00,Q9GZY8,Q9Y2R0,O60830,Q9Y4P3,Q6UXV4,O94901,Q13505,Q6ZRP7,Q96K12,P57088,Q03518,Q86XL3,Q15286,Q86YN1,Q9Y282,Q9BUN8,Q99595,P17152,O43505,Q5J8M3,P42892,Q15388,Q10471,O75844,Q15070,P57105,O15258,O14925,P04439,Q9UH99,Q15629,Q99442,Q8NC56,Q7L0J3,Q92643,Q14739,O15126,Q6P4A7,A0FGR8,Q5SNT2 Localization GO Cellular component msigdb_gocc 402,410,137,138,8,411,141,258,15,396,287,278,30,283,425,309,186,184,56,299,178,454,188,304,328,68,330,446,441,321,202,225,85,496,221,88,222,91,212,488,470,118 470,636,471,321,2481,212,441,178,638,640,592,8,1069,68,2335,856,1309,258,2821,799,800,2968,202,1077,1161,2418,299,2181,2081,2495,937,1639,2831,188,2633,749,1004,2435,2095,278,446,1912,2874,2959,1655,30,328,1012,15,1573,91,2283,330,1931,425,304,85,663,571,3164,1330,1414,454,118,1841,488,141,396,88,1505,283,2961,309,574,968,1845,764,1680,221,1683,970,1513,768,222,2219,2653,1117,287,1039,2395,496,56,2309,1859,402,184,1958,1435,137,1437,2887,1865,2401,841,842,685,537,3068,776,2149,1131,3014,1965,1446,631,1705,225,410,186,138,411,1535,1455,925 0.603398739242378,0.4540235095844826,0.603398739242378,0.8217925949426864,-0.5133061398194652,1.033866168077631,0.640258997817798,1.1719772075302926,0.4540235095844826,0.4540235095844826,0.49166307589473773,5.710127312386168,0.1847155783283068,2.1365684786427637,-0.4280193129695504,0.30141428148632216,0.06603905308700285,0.9285879028743135,-0.7740882787487618,0.33988043265628903,0.33988043265628903,-0.996960006644522,1.0686319460690494,0.1847155783283068,0.1453758906367192,-0.47055931834629494,0.8575633322997649,-0.34356283749264765,-0.30164793499149467,-0.5133061398194652,0.26273353937402294,-0.09523903258909394,-0.7740882787487618,1.1376854683380586,-0.5994172002524207,0.3781352496108558,0.22383486656935098,-0.47055931834629494,-0.30164793499149467,0.8931610038007228,0.640258997817798,-0.21844879395768765,-0.8182620339173361,-0.9519864382224174,-0.09523903258909394,3.455451002526678,0.8217925949426864,0.22383486656935098,4.446515041621976,-0.05459618476215373,1.7962380654131864,-0.3856868930458746,0.8217925949426864,-0.21844879395768765,0.6769313036646232,0.8575633322997649,1.8591793954863818,0.4540235095844826,0.529103559661836,-2.134368980481475,0.06603905308700285,0.026043738945028046,0.640258997817798,1.5394161307024605,-0.17716618352898394,0.603398739242378,1.4078086405789536,0.7134182805889118,1.8277698868878607,-0.014168302611951702,0.8931610038007228,-0.9519864382224174,0.8575633322997649,0.529103559661836,0.26273353937402294,-0.17716618352898394,0.3781352496108558,-0.09523903258909394,1.033866168077631,-0.09523903258909394,0.26273353937402294,-0.014168302611951702,0.3781352496108558,1.033866168077631,-0.34356283749264765,-0.5994172002524207,0.1847155783283068,0.8931610038007228,0.22383486656935098,-0.4280193129695504,0.603398739242378,2.4926471507031023,-0.3856868930458746,-0.17716618352898394,0.7134182805889118,1.1719772075302926,-0.21844879395768765,0.026043738945028046,1.4409187687914826,0.026043738945028046,-0.8182620339173361,-0.17716618352898394,-0.4280193129695504,0.33988043265628903,0.33988043265628903,0.4540235095844826,0.566347842731351,-1.178830334389834,0.3781352496108558,-0.30164793499149467,0.1847155783283068,-1.0421318380239888,-0.21844879395768765,0.026043738945028046,0.49166307589473773,-0.09523903258909394,1.033866168077631,0.7134182805889118,1.1719772075302926,1.4409187687914826,0.7134182805889118,-0.014168302611951702,0.026043738945028046,0.30141428148632216 3193 Amide binding 26 100 3.583524342977951 0.0003389891555392 Q9NZ08,O43731,O00154,P55786,P49748,P24390,Q03518,Q9UIQ6,P45877,P21796,Q9NZJ7,Q9NQX7,Q8WTV0,P49327,P42892,Q15388,P45880,Q15392,P07602,P04439,P35610,P11498,P05165,Q9Y680,Q5SW96,P50747 Functions GO Molecular function msigdb_gomf 133,139,256,18,148,22,30,32,277,37,167,45,51,54,188,304,69,75,79,202,84,344,342,101,229,244 256,1969,1219,1970,1144,787,2329,2166,1973,139,2411,1306,1309,1311,2968,202,342,79,1896,2777,1077,344,2079,2623,37,1080,1729,22,1164,2495,1165,346,84,1731,2429,2690,1084,1733,188,277,69,3079,54,148,1241,1242,244,1560,2505,1561,18,2439,2874,2834,2098,2791,2101,1827,3004,30,2277,2199,1490,2699,1257,2201,2577,2373,2450,304,75,229,3089,1843,457,51,2461,2389,672,1202,578,835,3008,1040,2886,2468,977,3135,628,1699,45,540,133,167,1290,1213,32,2602,3054,101 0.9285879028743135,-0.25994298419798034,0.10581674080916348,-0.25994298419798034,0.1453758906367192,0.33988043265628903,-0.4280193129695504,-0.34356283749264765,-0.25994298419798034,1.4078086405789536,-0.47055931834629494,0.06603905308700285,0.06603905308700285,0.06603905308700285,-0.996960006644522,1.0686319460690494,0.7858464474140958,1.9216366583397482,-0.21844879395768765,-0.7301162059779877,0.1847155783283068,0.7858464474140958,-0.30164793499149467,-0.5994172002524207,2.8902828388919057,0.1847155783283068,-0.13609598281271182,4.0375706796337205,0.1453758906367192,-0.5133061398194652,0.1453758906367192,0.7858464474140958,1.8591793954863818,-0.13609598281271182,-0.47055931834629494,-0.6427799465527326,0.1847155783283068,-0.13609598281271182,1.1376854683380586,0.8931610038007228,2.1365684786427637,-1.2247886777807828,2.4926471507031023,1.3411620038373298,0.10581674080916348,0.10581674080916348,0.9638462735845957,-0.05459618476215373,-0.5133061398194652,-0.05459618476215373,4.232113451896606,-0.47055931834629494,-0.8182620339173361,-0.7740882787487618,-0.30164793499149467,-0.7301162059779877,-0.30164793499149467,-0.17716618352898394,-1.0421318380239888,3.455451002526678,-0.3856868930458746,-0.34356283749264765,-0.014168302611951702,-0.6427799465527326,0.10581674080916348,-0.34356283749264765,-0.5562590173955732,-0.4280193129695504,-0.47055931834629494,0.8575633322997649,2.045139224212076,0.9989383120950578,-1.270942049462474,-0.17716618352898394,0.640258997817798,2.5505745310028187,-0.47055931834629494,-0.4280193129695504,0.4540235095844826,0.1453758906367192,0.529103559661836,0.33988043265628903,-1.0421318380239888,0.22383486656935098,-0.8182620339173361,-0.47055931834629494,0.26273353937402294,-1.5046126429246862,0.49166307589473773,-0.09523903258909394,2.6652800068985742,0.566347842731351,1.4738889842432312,1.2401003260948613,0.10581674080916348,0.1453758906367192,3.1906830265014583,-0.5562590173955732,-1.1330676522557266,1.7008953568023113 3193 Ion transport 31 200 3.5197002998595512 0.0004320346807356 Q9UHG3,Q96ES6,Q9Y6M7,O43772,P21796,Q9NZJ7,Q9UDW1,P51798,Q9H2D1,P46934,P30536,Q9HD20,Q70HW3,O75844,P45880,Q9C0H2,Q13423,P07602,Q8TDW0,Q7L0J3,Q9HC07,Q9Y619,Q7KZN9,P53985,Q12959,Q9BQT8,Q9UBX3,Q13555,P42858,O75964,P08183 Processes and pathways GO Biological process msigdb_gobp 4,5,25,26,37,167,42,170,50,169,53,59,64,68,69,76,77,79,81,88,89,92,95,102,103,109,110,108,107,106,120 689,2950,2925,1790,2991,2547,1882,589,694,997,26,638,2607,2673,363,641,2333,1068,1376,1887,243,68,507,1223,106,856,555,999,800,699,1890,2928,1632,2255,3167,3057,1074,1893,2073,2488,2677,2617,79,2929,120,1464,1159,3111,2178,2778,1991,261,1161,647,388,1726,2680,1805,2491,1467,2181,2082,2182,2739,2346,37,1163,596,2682,936,3096,743,1165,53,2998,1083,2088,1811,805,2000,2745,2630,1733,107,69,2003,169,2434,808,2354,1091,3171,170,3085,325,102,2873,1169,877,1170,1562,878,1479,2874,2754,2098,1743,3150,2959,1655,1657,1745,3004,952,3038,1253,2199,3061,1921,2367,103,77,1830,108,480,3040,246,1929,883,371,884,2879,1580,1757,571,426,172,2517,1187,488,667,64,95,88,893,1109,3065,3128,766,1683,354,970,81,2460,2711,5,2302,902,1039,771,2047,3008,289,3047,2309,109,1603,2529,1043,76,2809,3066,582,50,1698,1358,1865,89,841,59,1700,1441,845,167,110,42,1618,4,2854,502,1706,410,2241,2477,469,3017,1535,92,2407,25 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3193 Ion transmembrane transport 25 154 3.3654679605091524 0.0007641394103197 Q9UHG3,Q96ES6,Q9Y6M7,O43772,P21796,Q9UDW1,P51798,Q9H2D1,Q9HD20,Q70HW3,O75844,P45880,Q9C0H2,Q13423,Q8TDW0,Q9HC07,Q9Y619,Q7KZN9,P53985,Q12959,Q9BQT8,Q9UBX3,P42858,O75964,P08183 Processes and pathways GO Biological process msigdb_gobp 4,5,25,26,37,42,170,50,59,64,68,69,76,77,81,89,92,95,102,103,109,110,107,106,120 2950,1790,2991,997,26,638,2607,2673,363,641,2333,1068,1376,1887,243,68,507,1223,106,555,999,699,2255,3167,3057,1074,1893,2488,2677,2617,2929,120,1464,1159,3111,2178,261,1161,647,388,1805,2491,1467,2181,2082,2182,2739,2346,37,1163,2682,936,3096,1165,2998,1083,1811,2000,2745,2630,1733,107,69,169,2434,808,2354,1091,3171,170,325,102,1169,877,1170,1562,1479,2874,2754,2098,1743,2959,1655,1657,952,3038,1253,1921,2367,103,77,1830,480,3040,246,1929,883,884,2879,1580,571,488,667,64,95,893,1109,3065,3128,1683,354,970,81,2460,2711,5,2302,902,1039,2047,3008,3047,2309,109,1603,2529,1043,76,3066,582,50,1698,1358,1865,89,841,59,1700,1441,845,110,42,1618,4,2854,502,1706,410,469,3017,1535,92,2407,25 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3193 Transporter 37 182 3.3458810807211914 0.0008202156470134 Q96ES6,O43731,Q92544,Q9BQE5,Q99808,P24390,Q9Y6M7,O43772,Q9HD45,Q03518,Q8IXU6,Q9NZJ7,Q9H2D1,Q6N075,Q15388,Q96FZ7,Q70HW3,Q15070,Q9Y487,P56377,O14653,P53007,Q9Y3A6,Q7L0J3,Q9HC07,Q9BTX7,Q8TAD4,Q9Y619,O95487,Q93050,P53985,Q9BQT8,Q96AX1,Q9UBX3,Q9Y6C9,O75746,P08183 Drugs and Diseases Pharos Drug Target Ontology pharos_dto 5,139,146,19,289,22,25,26,156,30,36,167,50,172,304,189,64,330,73,327,319,325,361,88,89,357,354,92,213,252,102,109,233,110,128,243,120 689,1879,1301,1065,1144,787,2990,927,319,341,139,3155,26,638,592,1375,2411,2169,2552,641,1629,243,1223,1979,555,1981,1889,1228,213,1073,800,2255,3167,1074,2488,120,1464,2777,2778,2737,1161,647,2418,1805,2780,2181,2182,2739,22,1163,2682,743,1235,1811,1472,2000,2351,2630,1733,1906,2270,874,1090,2435,3085,1560,2505,325,2274,2437,1398,102,1649,2873,1169,2009,877,2094,1170,327,1562,1911,1479,2874,2359,2791,2959,1655,1745,1410,952,30,2698,1748,1255,1749,567,393,2577,1015,3025,2373,884,330,2841,2879,3088,304,1580,172,2517,1187,64,88,2456,2961,36,1342,764,969,354,1343,970,1848,457,617,671,146,2389,252,830,233,1855,5,189,1039,1688,903,1518,906,289,19,109,3009,623,357,2918,1043,3066,3120,50,1698,2051,1358,1865,89,841,156,3068,167,2402,916,3156,467,2470,2238,110,2854,985,2240,502,2061,2664,781,361,547,73,2406,92,2326,128,25 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3193 Mitochondrion organization 35 189 3.3438025042097936 0.0008263854428147 Q9GZY8,Q9Y2R0,O60830,Q96CU9,O95429,Q6UXV4,P04062,Q13505,P55786,Q9GZT3,Q5JRX3,P21796,Q99797,Q9BUK6,Q9NS69,P14406,O43676,P30536,Q99595,P17152,O95831,Q69YU5,Q15388,O75153,P45880,Q15070,O14925,Q16706,O75306,Q5T9A4,Q8N4H5,Q9UDX5,P42858,Q9Y6C9,Q9H061 Processes and pathways GO Biological process msigdb_gobp 137,138,8,9,140,141,259,15,18,290,158,37,166,313,41,44,46,53,56,299,58,305,304,60,69,330,321,98,97,372,231,111,107,128,126 1709,637,3056,1301,3175,2925,2606,321,1971,2671,853,46,640,1461,8,60,1628,1068,97,1376,1069,1887,1888,1541,2335,1309,2821,554,555,642,2927,140,2863,58,800,2175,1890,259,3073,1891,1074,2415,1633,1545,2618,2620,1161,44,299,475,37,3096,2625,2085,1165,2497,53,2743,2089,2427,1642,2831,2500,107,69,808,2934,1396,874,3144,1818,657,2435,751,1648,876,18,1822,2507,1250,2639,1657,2641,661,15,3160,2280,1259,330,1755,304,2377,1413,571,98,2379,426,1330,3165,1499,1414,158,372,2582,1841,305,1672,141,2844,1266,2122,1504,574,968,1845,1340,1194,2798,1506,231,1947,2126,2761,1683,3159,2799,2128,2460,2521,2653,769,9,1275,1688,462,974,1280,2047,905,56,3008,2397,166,1353,1603,623,1206,313,1958,1435,290,137,581,126,1437,1960,1699,2919,1528,629,41,1211,1778,776,912,2657,914,1529,2149,687,1288,543,3091,111,1705,2661,1706,780,138,1787,3082,1059,382,1535,1455,2725,1142,128,438 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3193 Tdark 95 333 3.209410902310802 0.0013300726195508 Q9Y3B3,Q96ES6,O60830,Q96CN7,Q969T7,Q86YQ8,Q86U38,Q7L8L6,Q5TFE4,Q8IXU6,Q9BWJ5,Q8IYS2,P14406,Q5VW38,Q9HD20,Q9NR77,Q969E2,Q8TDW0,Q5JSZ5,Q15629,O75964,Q5SNT2,Q9UKR5,Q96DM3,O43731,Q9Y2W6,O94915,Q9HD45,Q9Y305,Q8N128,Q5C9Z4,Q8NE00,Q6N075,Q9P0M9,Q9BV19,Q9H9Y2,Q9Y6J9,Q8IXT5,Q9NXF1,Q8NC56,Q7Z4H3,O15126,Q9H1I8,Q9BQ61,Q8N4H5,Q9BWH6,Q7Z2K6,P84157,Q9NVE7,Q96LJ7,Q9NU22,Q8N3Z3,Q8IZD4,Q86YN1,Q96SK2,Q6UW68,Q9Y3E0,Q6DKI1,P17152,Q69YU5,Q9NX00,Q8NBN7,Q8N8A6,Q9NUD5,Q9BTX7,Q6P1L8,Q14997,Q6ZXV5,P82930,Q8WUJ1,Q96SI9,Q96SY0,Q9BXW7,Q9NYK5,Q8NC54,Q15345,O94919,Q8NCA5,Q8WVC6,Q96A35,Q9P2K5,P61009,Q5J8M3,Q96C01,Q3SXM5,O15213,A0AVF1,Q96P11,Q9BSC4,Q9H1E5,Q5VTL8,Q5T653,Q14690,Q9BVQ7,Q96F63 Drugs and Diseases Pharos IDG Category pharos_protein_category 547,5,8,528,28,523,522,520,519,36,579,575,44,52,59,66,67,81,82,85,106,118,127,123,139,143,152,156,160,159,164,173,172,185,190,192,193,207,224,221,219,212,236,234,231,254,250,245,273,288,293,285,284,309,312,307,316,306,299,305,338,335,334,359,357,353,352,373,368,399,400,401,403,409,397,395,386,428,430,431,435,423,454,460,453,440,439,495,498,499,487,486,481,533,529 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3193 Oxidoreductase activity 34 222 3.098905560743671 0.0019423692390321 Q9UHG3,Q9H3N1,P30519,Q96CU9,P11413,P23378,P49748,Q96K12,Q15800,Q96LJ7,O95864,Q8NBX0,Q06136,P09601,Q9UDW1,P14406,O43676,P49327,O95831,P04035,Q15392,Q13423,P13674,O15460,O43169,Q14739,O43396,Q7KZN9,P30837,O75306,Q8NB78,O75845,Q32P28,Q16850 Functions GO Molecular function msigdb_gomf 4,270,7,9,261,144,148,287,150,288,153,27,31,35,42,44,46,54,58,194,75,77,80,201,87,91,93,95,214,97,104,105,248,115 1218,3175,412,2164,1790,1880,471,928,201,87,3072,93,505,46,640,1537,1794,2672,1068,97,998,1888,2774,105,1154,2611,2336,554,1379,642,58,153,2994,1380,1311,645,2487,699,2864,194,3073,2616,1984,2734,861,1897,1159,3076,2930,35,1804,1990,2178,1992,1724,261,2417,2866,2867,388,2077,80,1727,2078,44,932,2420,3183,935,2561,2082,2423,1315,595,700,1081,144,2783,2265,3096,2625,1003,2626,2268,2085,1639,7,214,745,1553,1083,2628,2685,2744,1556,2352,2499,2187,1084,1644,940,1394,808,2501,1396,2632,2935,54,3100,148,2091,1243,2633,944,601,1820,1245,751,2504,2273,1248,1477,1319,2097,1743,2363,714,1827,1096,31,2448,1922,954,2369,1014,77,1570,2282,91,2027,819,2286,75,758,150,663,2379,426,759,115,248,453,1759,427,2978,331,1762,2911,666,2584,2292,1502,614,2208,2293,396,95,2294,3126,1585,1677,1424,2649,3065,1947,3187,104,335,721,27,1114,1766,768,3119,2461,1036,9,1771,902,287,288,2047,905,2397,1040,3009,1123,1773,3180,1695,2140,270,628,1699,2401,292,2146,2718,1285,1779,1131,1288,631,1783,42,4,1530,688,848,1625,1058,438 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3193 Envelope 160 466 3.0703642111382963 0.0021379787971314 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Localization GO Cellular component msigdb_gocc 537,2,539,542,8,9,12,13,15,508,23,26,515,35,37,571,41,42,574,44,46,580,50,53,56,58,62,64,554,555,68,69,564,77,617,621,622,87,623,625,91,92,627,629,95,631,97,589,109,110,111,106,604,118,128,126,672,132,666,137,138,135,141,684,687,148,661,151,648,640,641,642,645,647,637,650,167,659,663,655,726,185,723,724,189,727,714,700,712,692,200,225,698,699,221,702,769,771,231,776,780,251,762,761,749,243,246,745,266,264,751,258,263,752,826,827,822,825,823,278,820,846,836,838,313,299,305,304,335,331,330,321,325,353,351,348,372,368,362,402,409,396,388,431,438,426,417,469,462,446,449,499,502,488,486,477,485,472,473,479 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3193 Abnormal bone structure 43 174 3.0003920131752406 0.002696323419796 Q14108,Q9NSE4,O96028,Q9Y4P3,P10644,P04062,O75718,Q9H9Y6,Q12756,P16278,Q9NZJ7,Q86XL3,Q9H1A4,P51798,Q13126,Q96RR1,O95831,Q96L58,Q8WWQ0,O75844,Q9Y487,Q15392,Q9BUR4,P07602,Q96HY6,Q8NC56,Q9HC07,Q14739,Q9Y619,Q08AM6,P05165,P06400,P22681,Q9BV10,O75845,P40818,P54098,Q32P28,Q8NCM8,Q15042,Q07864,Q96HA7,O15360 Drugs and Diseases Human Phenotype Ontology msigdb_hp 6,407,134,411,260,259,385,291,392,33,167,283,176,170,48,183,58,337,336,68,73,75,78,79,223,221,89,91,92,350,342,343,345,235,105,226,114,248,375,371,369,125,119 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3193 Endoplasmic reticulum 60 193 2.9813401610254844 0.0028698981852979 Q8WUJ1,Q9NQC3,Q6UWP7,Q9H3N1,Q9UM00,O43731,Q96CN7,P43307,O75915,Q15800,Q5BJF2,P18621,Q03518,O96005,P00387,Q14257,P62266,P62841,Q86XL3,Q6UW68,Q9BUN8,Q15293,Q96A57,P27635,P35790,Q96G23,Q8TCJ2,Q9P2W9,P62753,P67809,P61803,O43852,P36578,Q9BT22,P62917,P13674,O15460,P35610,O43169,Q96HY6,O60831,Q99442,Q8TED0,Q9UBM7,Q9Y680,P46779,Q9BV10,P47914,P50402,O00767,P46776,O75845,Q16850,P62910,Q86UE4,Q14697,P84157,P51648,Q8NHP6,Q9H3G5 Localization Protein Atlas Subcellular protein_atlas_subcellular_location_all 399,537,668,270,410,139,528,16,507,150,23,389,30,644,645,157,162,279,283,307,184,570,459,557,61,65,199,467,563,564,562,322,560,624,203,80,201,84,87,223,363,496,494,631,101,599,235,347,348,471,227,105,115,117,251,608,245,601,670,404 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3193 Abnormality of bone mineral density 37 132 2.953278321579428 0.0031441834153631 Q14108,Q9NSE4,O96028,Q9Y4P3,P10644,P04062,O75718,Q9H9Y6,Q12756,P16278,Q9NZJ7,Q9H1A4,P51798,Q13126,Q96RR1,O95831,Q96L58,Q8WWQ0,O75844,Q9Y487,Q15392,Q9BUR4,P07602,Q96HY6,Q8NC56,Q9HC07,Q14739,P05165,P22681,O75845,P40818,P54098,Q32P28,Q15042,Q07864,Q96HA7,O15360 Drugs and Diseases Human Phenotype Ontology msigdb_hp 6,407,134,411,260,259,385,291,392,33,167,176,170,48,183,58,337,336,68,73,75,78,79,223,221,89,91,342,345,105,226,114,248,371,369,125,119 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3193 Abnormal cellular phenotype 28 186 2.910538909754932 0.0036080603870165 Q14108,Q9GZY8,Q9Y2R0,Q96CU9,P49748,O43772,P09601,Q9NZJ7,P51798,O43676,Q96RR1,P49327,Q70HW3,O75844,P07602,Q92643,Q14739,O00443,Q7KZN9,O75306,Q9BV10,Q96AX1,Q9UBX3,P54098,O75503,Q96HA7,O75648,O15360 Drugs and Diseases Human Phenotype Ontology msigdb_hp 6,137,138,9,148,26,35,167,170,46,183,54,64,68,79,222,91,211,95,97,235,233,110,114,116,125,242,119 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3193 Vascular skin abnormality 26 117 2.810543353495318 0.0049457925305276 Q14108,P53701,P10644,P04062,Q8NCH0,Q5T2R2,Q06136,P16278,Q9H1A4,P51798,Q13126,P49327,Q96L58,O75844,Q7Z5L9,Q9Y487,Q08J23,Q9BUR4,Q8NC56,P10619,Q14739,O75306,P22681,P40818,Q07864,O15360 Drugs and Diseases Human Phenotype Ontology msigdb_hp 6,135,260,259,398,145,31,33,176,170,48,54,337,68,333,73,205,78,221,90,91,97,345,226,369,119 3056,2727,119,1886,2672,1067,552,97,1378,68,1227,2897,1310,699,2968,2175,259,2253,2898,1801,1313,90,260,2738,1385,1901,33,2491,863,1468,2346,1315,1316,345,2870,2495,652,653,1997,805,2350,2745,1557,868,2630,2498,226,2902,874,54,1475,601,170,1739,135,1649,1399,1248,1400,2959,1917,1096,1488,31,369,205,48,3024,6,451,1497,91,1930,1931,1755,1933,483,758,2795,1023,145,1763,2517,1187,2586,2209,333,2706,2458,1110,221,398,1509,2523,2219,899,973,337,2304,1600,2713,78,2849,2140,176,1126,2532,1529,3052,631,436,1623,3016,990,73,2406,993 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3193 Abnormal lower limb bone morphology 39 166 2.7822028089131825 0.0053991288968275 O96028,P10644,P04062,P13073,O75718,Q12756,P16278,Q03164,Q9NZJ7,Q9H1A4,P51798,Q7LGA3,O95831,O43505,Q10471,Q96L58,O75844,Q9Y487,Q08J23,Q9H2M9,Q15392,P07602,Q9UHX1,Q96HY6,Q8NC56,Q14739,Q9Y619,O00443,Q08AM6,P06400,Q9BV10,Q13555,P42858,O75845,Q32P28,Q8NCM8,Q96HA7,O75648,O15360 Drugs and Diseases Human Phenotype Ontology msigdb_hp 134,260,259,388,385,392,33,163,167,176,170,308,58,178,328,337,68,73,205,209,75,79,83,223,221,91,92,211,350,343,235,108,107,105,248,375,125,242,119 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3193 Peptidase activity 34 114 2.7777656657494534 0.0054734075796485 Q9NZ08,Q9P275,Q9UBR2,P42785,P55786,O76031,P81605,P49721,Q9HBH5,P28074,Q5JRX3,Q9UIQ6,P83111,Q9NUQ7,Q9HB40,Q99797,Q4J6C6,P61009,Q16740,P22695,Q13867,P28072,P42892,O75844,P28070,P51665,Q9H4L4,P10619,Q92643,Q9Y4E8,Q9Y4P1,P40818,Q7Z2K6,Q9H3G5 Functions GO Molecular function msigdb_gomf 133,543,544,10,18,508,149,24,292,390,158,32,280,434,38,166,573,423,49,417,569,180,188,68,558,445,358,90,222,240,382,226,250,404 926,2726,2166,1884,2671,591,1887,68,1224,508,2554,2732,1890,2617,1989,90,1385,1546,2079,1386,2262,417,2494,558,180,390,2426,2267,1639,1556,1642,226,2433,10,188,2353,2269,2190,24,2503,445,2272,810,1561,2506,2747,18,1741,423,1008,149,280,2510,661,1747,569,1020,2109,818,49,573,887,158,1940,613,890,965,669,250,1844,2125,1513,2039,222,1853,2523,898,1597,2041,2390,901,972,2462,1277,833,974,2046,1280,2047,3166,166,2713,1433,2468,404,1864,358,3067,38,292,3177,1359,2851,434,1362,133,543,544,32,2603,240,382,1535,2541 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3193 Outer membrane 27 93 2.537141710105439 0.0111761703679791 Q9NVH0,Q9NZ45,Q9GZY8,Q99720,Q6UXV4,Q13505,Q8NBU5,Q9HCL2,Q13057,P09601,Q16611,P21796,Q9NZJ7,Q9NS69,Q9BUK6,P30536,Q15388,Q9Y277,P45880,Q5VT66,Q96RL7,P57105,O43169,P42345,P50402,Q8N4H5,Q9Y6C9 Localization GO Cellular component msigdb_gocc 539,542,137,13,141,15,263,151,515,35,571,37,167,41,313,53,304,469,69,331,462,446,87,477,348,231,128 637,1219,2925,2329,87,1461,1716,1376,1069,1309,2821,698,800,645,2995,1633,35,1806,37,53,2087,2831,477,870,69,348,749,1648,1477,446,2360,515,15,3160,1755,304,2377,571,1330,1414,331,1841,666,761,141,822,574,968,1845,2588,1506,231,2126,2761,263,826,1197,897,2653,1770,1275,462,2045,905,3008,13,313,1958,2529,1435,137,1961,151,1528,629,2315,41,2597,539,776,2657,914,2149,846,542,167,984,631,1705,469,3082,1455,128 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3193 Oxidoreductase 26 167 2.4879408387953 0.0128485104601636 Q9UHG3,P30519,Q96CU9,P11413,P23378,P49748,Q96K12,Q15800,Q96LJ7,O95864,Q8NBX0,Q06136,P09601,P49327,O95831,P04035,Q15392,P13674,O15460,Q14739,P30837,O75306,Q8NB78,O75845,Q32P28,Q16850 Functions Protein Atlas Molecular function protein_atlas_molecular_function 4,7,9,261,144,148,287,150,288,153,27,31,35,54,58,194,75,80,201,91,214,97,104,105,248,115 3175,2164,1880,471,928,201,3072,505,1794,2672,1068,97,1888,105,1154,2336,58,153,2994,1380,1311,645,2487,194,3073,2616,1984,2734,1897,2930,35,1804,1992,1724,261,2866,2867,388,80,2078,932,2420,3183,935,2561,2423,1315,595,700,1081,144,2783,2265,2625,1003,2626,2268,2085,7,214,745,1553,2628,2685,2744,1556,2499,2187,1084,1644,940,1394,2501,2632,2935,54,3100,148,2091,1243,2633,601,1820,1245,2504,2273,1248,1319,1743,2363,714,1827,1096,31,2448,1922,954,2369,1014,1570,2282,91,2027,819,75,758,150,663,759,115,248,1759,427,2978,331,1762,666,2584,2292,614,2208,2293,396,2294,3126,1677,1424,2649,3065,1947,3187,104,335,721,27,1114,1766,768,3119,2461,1036,9,1771,902,287,288,905,2397,1040,1123,1773,3180,1695,2140,1699,2401,292,2718,1285,1779,1131,631,1783,4,1530,688,1058 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3193 Abnormal sternum morphology 26 106 2.4824334778605937 0.0130488429451447 Q9BTV4,O96028,Q9Y4P3,Q8NCH0,P04062,O75718,P16278,Q03164,Q9BUK6,Q7LGA3,O00330,O95831,Q96L58,Q9Y487,Q08J23,Q9H2M9,P53007,Q9UHX1,Q14739,Q9Y619,O00443,Q08AM6,P22681,Q96AX1,P50402,Q8NCM8 Drugs and Diseases Human Phenotype Ontology msigdb_hp 402,134,411,398,259,385,33,163,313,308,412,58,337,73,205,209,325,83,91,92,211,350,345,233,348,375 412,211,2164,3032,1373,1886,1718,2484,1069,385,555,58,134,2175,259,3020,1802,33,2261,2346,1315,345,1729,1232,2185,1997,2830,1473,2428,1238,1644,348,1476,1245,1739,2092,325,1248,877,513,1911,708,1172,2790,2195,1322,2099,2445,1917,1096,163,1488,1253,350,205,1014,1101,3040,1497,91,2907,483,1756,886,1762,1763,2209,308,1504,398,375,1509,826,2219,1117,233,672,1036,2221,461,2133,973,337,577,2395,402,1957,313,2766,209,2887,1126,1964,912,982,83,919,1623,2062,3137,1708,73,1368,411,849,92 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3193 Inorganic ion transmembrane transport 14 111 2.433906409858095 0.0149368566421024 Q9HC07,Q9UHG3,Q96ES6,P21796,Q12959,Q9UDW1,Q9UBX3,Q13423,P42858,O75964,P51798,Q9Y6M7,Q9HD20,Q7KZN9 Processes and pathways GO Biological process msigdb_gobp 89,4,5,37,103,42,110,77,107,106,170,25,59,95 1790,2991,997,2673,641,1068,1376,1887,1223,106,555,999,699,2255,3167,1074,1893,2488,2677,2929,1464,1159,2178,261,1161,388,1805,2491,1467,2181,2082,2182,2739,2346,37,1163,2682,936,3096,1165,2998,1083,2000,2745,2630,107,169,2434,808,2354,1091,3171,170,1169,877,1170,1562,1479,2874,2754,2098,1743,2959,1655,1657,952,3038,1253,1921,2367,103,77,480,3040,883,884,667,95,893,1109,3065,3128,1683,354,2460,2711,5,2302,902,2047,3008,3047,2309,1603,1043,3066,582,1698,1358,89,59,1441,110,42,1618,4,2854,1706,410,1535,25 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3193 Lipid metabolic process 50 269 2.392977845351125 0.0167122501866332 Q9H6V9,Q15120,Q96BW9,P11413,P04062,O00154,Q5T2R2,Q9BQE5,Q9NPH0,P49748,Q15800,Q9HCL2,Q96K12,O95864,Q9HBH5,Q8NBX0,Q92604,Q06136,P16278,P83111,Q9HB40,Q9NZJ7,Q86UY6,Q9UBV2,Q86YN1,P50897,Q8WTV0,P30536,P49327,Q9BZF3,P35790,Q96G23,O75844,P04035,Q8NCC3,Q15392,P07602,Q16880,P35610,Q92643,Q14739,Q2TAA5,O00443,P53985,Q9BV10,Q5SW96,O75845,Q16850,Q9UKR5,P48449 Processes and pathways GO Biological process msigdb_gobp 1,131,264,261,259,256,145,19,20,148,150,151,287,153,292,27,286,31,33,280,38,167,40,168,309,43,51,53,54,62,61,65,68,194,74,75,79,86,84,222,91,217,211,102,235,229,105,115,127,121 1061,1968,786,1218,256,211,2546,2329,471,320,2166,928,2481,692,851,996,2817,3154,2671,505,694,638,1716,506,1067,3018,796,1976,1306,2774,1796,68,105,1154,2336,2171,1631,799,698,859,2822,153,474,2733,645,194,259,2253,2928,2255,3057,342,1075,2898,2488,3033,931,79,3158,3076,1076,1989,1724,261,344,2866,1160,1727,2680,2972,932,2420,3095,3183,33,935,2491,1162,1386,2780,1467,595,1316,1388,1080,700,650,2349,2682,2265,743,2826,2626,2955,2185,53,2684,365,2087,3188,84,61,2427,1237,2352,561,868,3190,1084,1085,477,2500,655,1394,2090,121,2902,2270,54,148,749,43,1004,1476,601,1245,2191,1397,102,512,1477,2903,708,1402,2638,280,1656,3133,2574,3038,2278,1488,31,2448,350,661,1751,2576,1101,1832,1259,2282,91,1260,2027,1665,819,3134,131,1931,2842,2756,75,1934,962,758,150,663,1498,2288,759,115,86,572,217,2116,427,1414,229,145,1417,666,1187,668,2208,3163,892,40,1423,309,2124,1193,1506,615,3187,335,721,27,74,1111,576,310,1114,51,768,3119,286,222,2461,2219,264,65,287,2394,2395,3166,2306,3008,2397,1040,906,2713,19,624,1692,235,3191,3180,2885,2806,403,1695,1605,62,3011,3135,2887,1,628,1699,38,292,151,20,1527,405,1613,2988,2597,846,1131,167,3014,916,984,631,168,1617,1618,1784,920,1706,2322,127,1365,1620,2062,1058,784 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3193 Metabolism of lipids 38 180 2.375078360586062 0.0175452249779726 P04062,O00154,Q96K12,Q9NPH0,P49748,Q15800,Q9HCL2,O95864,O43772,Q92604,Q9Y305,Q06136,P16278,Q9NZJ7,Q8TBX8,P50897,P30536,P49327,Q9BZF3,P35790,Q96G23,P04035,Q15165,Q8NCC3,Q15392,O14734,P07602,P53007,Q16880,P35610,P10619,Q14739,O00443,Q08AM6,O95487,O75845,Q16850,P48449 Processes and pathways Reactome Pathways msigdb_reactome 259,256,287,20,148,150,151,153,26,286,160,31,33,167,310,43,53,54,62,61,65,194,71,74,75,320,79,325,86,84,90,91,211,350,213,105,115,121 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3193 Receptor 9 28 2.2924331301419363 0.0218806621031757 Q567V2,Q9NR77,Q14108,Q12959,A6NIH7,Q13432,Q8WTV0,Q9UQB8,O95782 Drugs and Diseases Pharos Drug Target Ontology pharos_dto 2,66,6,103,11,14,51,21,94 11,2548,2482,797,2730,94,1893,1230,416,654,446,350,103,14,1494,6,2,2584,51,2650,184,2052,66,1048,2813,1054,1619,21 5.130323467956688,-0.5562590173955732,-0.5133061398194652,0.33988043265628903,-0.6863465232630938,1.7645826062622836,-0.21844879395768765,0.10581674080916348,0.6769313036646232,0.4540235095844826,0.640258997817798,0.7858464474140958,1.6366970559736984,4.5169784040611045,-0.014168302611951702,5.751875548006099,7.52513443582088,-0.5562590173955732,2.5505745310028187,-0.5994172002524207,1.1719772075302926,-0.25994298419798034,2.1969681791216726,0.22383486656935098,-0.7301162059779877,0.22383486656935098,-0.05459618476215373,4.086568005797333 3193 Transport of small molecules 26 147 2.2789960302899464 0.0226673012793394 P30519,P10644,P49721,Q9Y6M7,P09601,P21796,Q99797,Q9UBV2,P51798,Q8WTV0,Q9BUN8,P28072,Q9HD20,Q70HW3,P45880,Q9Y487,Q9C0H2,Q8TDW0,P35610,O95782,P53985,Q9UBX3,Q13555,Q5SW96,Q93050,P08183 Processes and pathways Reactome Pathways msigdb_reactome 7,260,24,25,35,37,166,168,170,51,184,180,59,64,69,73,76,81,84,94,102,110,108,229,252,120 1789,2163,2545,2726,2167,2481,790,641,1887,1541,2611,2171,2730,555,94,1890,2255,3167,1074,2556,861,120,1464,2777,35,260,2778,1161,647,2419,1805,2781,2181,2344,2262,2182,2739,649,37,2083,1234,2184,2494,936,2496,558,180,390,743,7,2998,2684,1811,2089,84,701,366,3113,867,2745,3190,2630,2690,3021,69,2631,2190,24,445,3171,170,1398,102,1169,877,2010,2570,2095,1741,2937,1479,1402,2752,2637,2361,2791,2362,2938,2959,1656,1745,2015,661,1922,1828,1830,108,480,1831,352,1834,884,1580,1936,229,1187,64,2035,1109,825,1683,354,970,81,51,2460,897,252,1202,974,2046,2917,3008,166,289,2309,1122,184,76,3066,1698,1358,59,3068,845,168,110,734,2854,1706,3092,2539,1621,469,73,1535,25 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3193 Golgi apparatus 35 166 2.258946416148732 0.0238867182215472 Q12893,Q8NC54,P80303,Q8NCH0,Q6ZRP7,Q9BRK5,Q96K12,P24390,Q9HD45,P16278,P09601,Q8IXU6,Q9HB40,O60637,P50897,Q8NE00,Q5VW38,Q02818,Q10471,Q9UID3,Q969E2,P18858,P56377,O14653,P04439,Q8TDW0,P53367,Q9BTX7,Q9HC07,Q92896,Q8TAD4,Q16706,O00461,P40818,Q93050 Localization Protein Atlas Subcellular protein_atlas_subcellular_location_all 136,397,12,398,396,147,287,22,156,33,35,36,38,39,43,173,52,55,328,339,67,196,327,319,202,81,326,357,89,355,354,98,100,226,252 1061,1877,850,1301,1789,100,2990,319,1712,2330,550,441,3131,929,2168,505,2993,3155,2070,1716,592,39,2552,740,2861,2484,1797,1798,1155,1799,2733,202,3057,1894,35,2416,1230,3095,33,196,1388,22,1001,1809,1638,2683,2830,1472,867,2689,226,2003,2188,1906,1090,1091,657,43,2872,1647,876,326,2274,2437,2956,327,1008,12,514,2959,1487,55,2447,328,2698,136,393,2514,2280,2372,1179,3174,884,98,1263,2117,963,1840,52,2120,1417,889,1029,2292,396,1420,1503,3189,2035,2961,456,1588,36,3006,2760,575,1110,720,1847,2520,397,398,173,354,1593,2708,1950,81,1849,1198,355,2711,252,67,3028,287,2304,2044,2135,772,3047,2803,147,357,1773,1356,2051,3135,1864,1960,1776,1609,3049,2313,2920,38,89,1700,156,1611,465,1613,1048,3108,2532,3148,984,2058,1705,339,2536,2538,633,2855,588,2326 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3193 Abnormal joint morphology 51 263 2.2565296241685338 0.0240374821871922 Q9BTV4,Q9NZ08,Q14108,Q9NSE4,O96028,Q9Y4P3,P10644,P04062,Q8NCH0,Q8NBU5,O75718,Q12756,P16278,Q03164,P07196,Q9NZJ7,Q86XL3,Q9H1A4,P51798,Q7LGA3,P49327,O95831,P42892,Q9H488,Q96L58,Q9NR77,O75844,Q9Y487,Q9H2M9,Q15392,P07602,O15460,P53007,Q9UHX1,Q96HY6,Q14739,Q9Y619,O00443,Q08AM6,P06400,P22681,Q9BV10,Q96AX1,P50402,P42858,Q8NCM8,Q6ZXV5,Q15042,Q96HA7,Q15022,O15360 Drugs and Diseases Human Phenotype Ontology msigdb_hp 402,133,6,407,134,411,260,259,398,263,385,392,33,163,274,167,283,176,170,308,54,58,188,191,337,66,68,73,209,75,79,201,325,83,223,91,92,211,350,343,345,235,233,348,107,375,373,371,125,370,119 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3193 Protein targeting 15 114 2.2405923093446387 0.0250524953347455 Q14108,Q9GZY8,O60830,Q9NS69,Q99797,O95429,P43307,P46934,P55786,P30536,Q15629,Q99595,O95831,O60725,Q5JRX3 Processes and pathways GO Biological process msigdb_gobp 6,137,8,41,166,140,16,169,18,53,85,56,58,29,158 2249,637,3056,1301,927,2606,2547,321,549,2671,853,694,1885,29,8,797,1887,1225,1309,2821,2927,140,2863,58,800,2415,1382,2340,2618,2619,2418,475,416,936,3035,3096,53,2786,365,3122,2743,2429,2690,16,197,169,874,3115,3144,1004,2435,18,2095,446,2750,423,2439,2874,3003,2754,1483,2443,2507,1657,661,2367,6,818,304,85,2377,1413,1499,1414,158,3062,1335,2456,2295,1504,3064,456,231,1947,462,1517,496,1280,2306,56,166,137,3141,2919,629,41,1211,1288,543,3091,918,1290,1618,2661,920,1292,2476,2157,3082,3017,1455,2725,1142,1215 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3193 Dyspnea 21 101 2.2369070430946056 0.0252924161459748 P53701,P10644,P04062,P49748,Q9NZJ7,Q96RR1,O95831,Q96L58,Q8TCJ2,O75844,Q7Z5L9,Q15165,P07602,Q9UHX1,Q9Y619,O75306,Q96AX1,Q5SW96,P54098,P50747,O75648 Drugs and Diseases Human Phenotype Ontology msigdb_hp 135,260,259,148,167,183,58,337,199,68,333,71,79,83,92,97,233,229,114,244,242 2951,640,1303,1717,1067,97,1222,242,68,2337,1889,1310,58,645,2968,2175,259,1312,2898,1801,79,1803,1898,1544,556,862,260,1899,1724,1161,1727,1547,1901,2559,2182,1078,2624,650,1997,1730,1731,2687,2352,2498,702,703,3100,148,244,3132,2006,751,325,511,2437,135,114,2570,2749,2439,2197,1655,1409,1252,2368,2449,1101,1102,956,2281,1930,2285,1755,71,663,2289,229,2586,2209,333,199,3103,618,1597,2219,233,831,337,183,1280,2396,1041,1206,582,977,1529,167,501,83,3016,92 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3193 Cognitive impairment 18 164 2.2285516383321946 0.0258437518960161 P16278,O75306,Q03164,Q9NZ08,Q14108,Q9Y2R0,Q9Y487,Q9NZJ7,P50897,Q99720,P42858,P07602,P54098,Q9BQE5,O75503,P49327,O95831,Q9Y619 Drugs and Diseases Human Phenotype Ontology msigdb_hp 33,97,163,133,6,138,73,167,43,13,107,79,114,19,116,54,58,92 2925,3109,2481,3154,2671,694,640,1461,740,3019,97,797,116,856,2821,799,58,800,699,2968,259,1983,1312,1891,3057,2898,3033,274,79,3158,1987,364,2930,556,1990,260,2778,1161,2418,3095,33,2261,2780,863,1468,2562,2346,1315,1316,2624,476,651,1469,745,1392,2744,1730,2745,2630,2690,477,870,107,702,2001,1905,54,2832,420,43,2872,1476,1245,1647,114,1247,1248,2570,2095,1911,707,2874,1402,3003,1745,1487,2574,163,2198,2278,1253,2199,661,2755,515,1411,2368,1256,3024,1101,6,956,2024,1497,1180,2643,483,2378,2116,664,1761,1841,1672,1105,717,2034,2587,1420,1193,2588,2126,1594,768,2461,1201,1516,461,1688,462,183,3007,1280,2047,2396,2397,13,19,1206,2804,1129,1866,1610,2315,732,1614,1615,133,167,2237,1783,734,501,1134,502,1620,1623,2062,138,2159,73,1535,1299,92,993 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3193 Protein transporter activity 6 13 2.2228842209603576 0.0262236080316544 O60830,Q9NS69,Q8NBU5,Q99595,Q9HD20,Q15388 Functions GO Molecular function msigdb_gomf 8,41,263,56,59,304 321,8,1309,800,1090,2874,304,263,56,59,41,918,2725 0.8217925949426864,5.710127312386168,0.06603905308700285,0.33988043265628903,0.1847155783283068,-0.8182620339173361,0.8575633322997649,0.9285879028743135,2.4926471507031023,2.4343271247364595,2.834566999031995,0.30141428148632216,-0.6427799465527326 3193 Primary mitochondrial disease 21 95 2.181507223214168 0.0291459207845243 Q9BW92,Q9Y2R0,Q96CU9,P13073,Q5T2R2,Q8NFF5,Q99797,Q9Y6M9,Q16795,O43676,P22695,Q96RR1,O95831,Q70HW3,Q7KZN9,O75306,Q9BQT8,Q9UBX3,P54098,P82930,O14949 Drugs and Diseases Protein Atlas Disease involvement protein_atlas_disease_involvement 268,138,9,388,145,429,166,438,426,46,417,183,58,64,95,97,109,110,114,368,362 3175,1790,362,46,1715,640,1461,1975,1068,97,998,1888,1072,2335,642,58,699,1897,1159,1544,1161,388,2868,2561,2082,417,2682,2625,745,870,1905,808,2356,2091,2635,511,114,2014,368,2639,754,426,1414,1415,664,1024,145,1761,1841,1672,488,64,95,1334,2846,2798,429,2980,2799,2128,9,461,1686,1119,183,166,1281,109,1353,1603,1206,268,909,1357,1699,1962,3161,1866,1529,1616,687,1288,2721,110,780,1451,138,923,2159,1214,2891,1297,1788,1060,438 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3193 Pain 35 173 2.164797077328387 0.0304032287447768 Q9BTV4,Q9NZ08,Q14108,Q9Y4P3,P11413,P10644,P04062,P49748,Q15800,Q9UER7,Q9NZJ7,Q9BUK6,P51798,Q96RR1,P49327,P42892,Q70HW3,Q9NR77,O75844,Q7Z5L9,Q15165,Q13423,P07602,O15460,Q96HY6,Q14739,P06400,P22681,P50402,Q5SW96,P40818,P54098,P08397,Q07864,Q96HA7 Drugs and Diseases Human Phenotype Ontology msigdb_hp 402,133,6,411,261,260,259,148,150,436,167,313,170,183,54,188,64,66,68,333,71,77,79,201,223,91,343,345,348,229,226,114,364,369,125 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3193 Positive regulation of cell population proliferation 33 121 2.162560767254372 0.030574978528751 Q9NQC3,Q13547,Q99584,P43307,Q9HCL2,Q8NCA5,P26583,P09601,P43490,P30536,O00330,P14635,Q8WWQ0,P62753,P06493,Q00839,P04439,P33981,O14786,Q969Z0,Q96HY6,Q9BSK2,Q7Z5K2,P55209,Q12959,P09429,Q9UBL3,Q5SW96,P78362,O95684,Q15058,P31751,Q15022 Processes and pathways GO Biological process msigdb_gobp 537,129,531,16,151,428,34,35,276,53,412,179,336,563,195,565,202,324,200,620,223,623,220,215,103,593,381,229,228,113,482,365,370 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3193 Cation transmembrane transport 13 118 2.143935245875173 0.0320380756107918 Q70HW3,Q9HC07,Q96ES6,P21796,Q12959,Q9UDW1,Q13423,P42858,Q9Y6M7,O43772,Q9HD20,Q9Y619,Q7KZN9 Processes and pathways GO Biological process msigdb_gobp 64,89,5,37,103,42,77,107,25,26,59,92,95 1790,2991,997,26,2673,641,1068,1376,1887,1223,106,555,999,699,2255,3167,3057,1074,1893,2488,2677,2617,2929,1464,1159,2178,261,1161,388,1805,2491,1467,2181,2082,2182,2739,2346,37,1163,2682,936,3096,1165,2998,1083,2000,2745,2630,107,169,2434,808,2354,1091,3171,1169,877,1170,1562,1479,2874,2754,2098,1743,2959,1655,1657,3038,1253,1921,2367,103,77,480,3040,883,884,2879,1580,667,64,95,893,1109,3065,3128,1683,354,2460,2711,5,2302,902,1039,2047,3008,3047,2309,1603,1043,3066,582,1698,1358,1865,89,841,59,1441,845,42,1618,2854,1706,410,1535,92,25 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3193 Lipoprotein metabolic process 6 15 2.130176902799316 0.0331570111895571 Q9NUJ1,Q9H2M9,P50897,P04062,Q9BQE5,Q92643 Processes and pathways GO Biological process msigdb_gobp 0,209,43,259,19,222 1067,1796,1631,259,2497,43,371,615,222,2219,2395,19,209,2887,0 0.1847155783283068,-0.17716618352898394,-0.09523903258909394,0.9285879028743135,-0.5133061398194652,2.7220719005400595,0.7497224929294436,0.49166307589473773,1.033866168077631,-0.34356283749264765,-0.4280193129695504,4.232113451896606,1.0686319460690494,-0.8182620339173361,8.915885944754063 3193 Abnormality of long bone morphology 37 173 2.112512803329339 0.0346424889711463 Q15022,Q9NSE4,O96028,Q9Y4P3,P10644,O75718,Q12756,P16278,Q9H1A4,P51798,Q13126,Q7LGA3,O95831,Q96L58,Q9NR77,O75844,Q9Y487,Q08J23,Q9H2M9,Q9BUR4,Q9UHX1,Q96HY6,Q9HC07,Q14739,Q9Y619,O00443,Q08AM6,P06400,Q9BV10,Q96AX1,P42858,Q32P28,Q8NCM8,Q07864,Q96HA7,O75648,O15360 Drugs and Diseases Human Phenotype Ontology msigdb_hp 370,407,134,411,260,385,392,33,176,170,48,308,58,337,66,68,73,205,209,78,83,223,89,91,92,211,350,343,235,233,107,248,375,369,125,242,119 1218,3056,2163,211,2164,3032,2727,1882,692,119,1716,2672,552,3173,1539,2484,797,1222,1069,1462,242,385,68,1154,555,1310,2485,58,2733,2486,134,2175,1891,343,1801,861,556,260,1465,1385,33,935,864,2182,2346,476,1001,2264,1810,653,2830,2428,1642,1237,561,868,2831,2430,3097,2690,107,2090,1906,2902,2632,1244,170,1739,511,877,2570,2095,2439,1823,2099,2100,2445,1487,2574,1917,1488,369,2448,350,205,392,1175,48,1014,2839,1664,1575,91,1833,370,2907,1931,1933,758,1935,1666,1581,248,1023,2289,1667,1762,1763,889,3089,2209,1420,308,2797,1504,2214,2588,1032,375,2709,3181,1849,1951,1597,2219,233,672,1036,2221,125,223,2133,337,577,2395,530,1041,2594,1957,78,235,2849,176,209,977,1210,1608,2887,1358,1126,89,1610,1963,66,407,434,2148,982,3052,2658,631,83,919,2922,545,3137,781,1451,3016,73,411,2066,92 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3193 Cation transport 16 149 2.1109072215857547 0.0347802872485119 Q70HW3,Q9HC07,O75844,Q96ES6,P21796,Q12959,Q9UDW1,Q13423,Q13555,P42858,P30536,Q9Y6M7,O43772,Q9HD20,Q9Y619,Q7KZN9 Processes and pathways GO Biological process msigdb_gobp 64,89,68,5,37,103,42,77,108,107,53,25,26,59,92,95 689,2925,1790,2991,1882,589,997,26,638,2607,2673,641,1068,1376,1887,68,1223,106,856,555,999,699,1890,1632,2255,3167,3057,1074,1893,2073,2488,2677,2617,2929,1464,1159,2178,1991,261,1161,388,1726,1805,2491,1467,2181,2082,2182,2739,2346,37,1163,596,2682,936,3096,1165,53,2998,1083,2088,805,2000,2745,2630,107,2003,169,2434,808,2354,1091,3171,3085,1169,877,1170,1562,878,1479,2874,2754,2098,1743,3150,2959,1655,1657,1745,3004,3038,1253,2199,1921,2367,103,77,108,480,3040,883,884,2879,1580,1757,571,426,667,64,95,893,1109,3065,3128,1683,354,2460,2711,5,2302,902,1039,2047,3008,289,3047,2309,1603,1043,3066,582,1698,1358,1865,89,841,59,1441,845,42,1618,2854,1706,410,2241,2477,1535,92,25 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3193 Protease 23 85 2.108478836807423 0.0349895914643021 Q9NZ08,P42785,P55786,P81605,P28074,Q5JRX3,Q9UIQ6,P83111,Q9NUQ7,Q9HB40,Q99797,Q16740,P28072,P42892,O75844,Q9H4L4,Q92643,P10619,Q9Y4E8,Q9Y4P1,P40818,Q7Z2K6,Q9H3G5 Functions Protein Atlas Molecular function protein_atlas_molecular_function 133,10,18,149,390,158,32,280,434,38,166,49,180,188,68,358,222,90,240,382,226,250,404 926,2726,2166,2671,591,1887,68,1224,2554,2732,2617,1989,90,1385,2079,1386,180,390,2426,2267,1642,226,2433,10,188,2353,2269,2503,2272,810,1561,2506,2747,18,423,1008,149,280,2510,569,1020,2109,818,49,573,158,1940,613,965,250,1844,1513,222,898,1597,2041,901,972,2462,1277,833,974,2046,2047,3166,166,2468,404,1864,358,3067,38,1359,2851,434,1362,133,543,544,32,2603,240,382,1535,2541 0.26273353937402294,-0.6863465232630938,-0.34356283749264765,-0.6427799465527326,0.49166307589473773,-0.21844879395768765,2.1365684786427637,0.10581674080916348,-0.5562590173955732,-0.6863465232630938,-0.5994172002524207,-0.25994298419798034,1.7962380654131864,0.026043738945028046,-0.30164793499149467,0.026043738945028046,1.1719772075302926,0.7134182805889118,-0.47055931834629494,-0.3856868930458746,-0.09523903258909394,0.9989383120950578,-0.47055931834629494,5.196307926254968,1.1376854683380586,-0.4280193129695504,-0.3856868930458746,-0.5133061398194652,-0.3856868930458746,0.33988043265628903,-0.05459618476215373,-0.5133061398194652,-0.6863465232630938,4.232113451896606,0.6769313036646232,0.22383486656935098,1.3411620038373298,0.8931610038007228,-0.5133061398194652,0.529103559661836,0.22383486656935098,-0.30164793499149467,0.33988043265628903,2.579393242759746,0.529103559661836,1.2739354625372552,-0.21844879395768765,0.49166307589473773,0.26273353937402294,0.9638462735845957,-0.17716618352898394,-0.014168302611951702,1.033866168077631,0.30141428148632216,-0.05459618476215373,-0.25994298419798034,0.30141428148632216,0.26273353937402294,-0.47055931834629494,0.10581674080916348,0.33988043265628903,0.26273353937402294,-0.25994298419798034,-0.25994298419798034,-2.134368980481475,1.2401003260948613,-0.47055931834629494,0.7134182805889118,-0.17716618352898394,0.7858464474140958,-1.178830334389834,2.8902828388919057,0.06603905308700285,-0.7740882787487618,0.6769313036646232,0.06603905308700285,1.4738889842432312,0.566347842731351,0.566347842731351,3.1906830265014583,-0.5562590173955732,0.9989383120950578,0.7497224929294436,-0.014168302611951702,-0.5133061398194652 3193 Lipid localization 12 69 2.08913288278392 0.0366957630624253 Q9H6V9,P08183,Q14108,Q99720,P07602,Q9BQE5,Q8WTV0,P30536,P35610,O43772,Q9BZF3,P35790 Processes and pathways GO Biological process msigdb_gobp 1,120,6,13,79,19,51,53,84,26,62,61 470,2329,2481,3131,26,638,1375,1228,698,859,2733,2615,259,2928,2677,79,3158,1987,120,1076,2778,2680,2179,2780,1388,1080,650,743,53,365,2087,1811,84,61,2270,749,1402,1656,1488,6,2282,1260,229,1417,1187,1266,2961,2915,51,2302,13,19,1859,1958,1605,62,2140,2051,1438,1,844,167,916,1617,339,1706,2322,2476,925 0.603398739242378,-0.4280193129695504,-0.5133061398194652,-1.5046126429246862,3.481516904512842,0.4540235095844826,0.026043738945028046,0.10581674080916348,0.41618190889414125,0.30141428148632216,-0.6863465232630938,-0.5994172002524207,0.9285879028743135,-0.9072118013025617,-0.6427799465527326,1.9216366583397482,-1.9372280716759664,-0.25994298419798034,1.5067209080288002,0.1847155783283068,-0.7301162059779877,-0.6427799465527326,-0.34356283749264765,-0.7301162059779877,0.026043738945028046,0.1847155783283068,0.4540235095844826,0.3781352496108558,2.4926471507031023,0.7497224929294436,-0.30164793499149467,-0.17716618352898394,1.8591793954863818,2.405017553399409,-0.3856868930458746,0.3781352496108558,0.026043738945028046,-0.09523903258909394,-0.014168302611951702,5.751875548006099,-0.3856868930458746,0.10581674080916348,0.9989383120950578,0.026043738945028046,0.1453758906367192,0.10581674080916348,-0.9519864382224174,-0.8626367719544891,2.5505745310028187,-0.3856868930458746,4.633342017395673,4.232113451896606,-0.17716618352898394,-0.21844879395768765,-0.05459618476215373,2.405017553399409,-0.30164793499149467,-0.25994298419798034,0.026043738945028046,7.965244774706002,0.33988043265628903,1.2401003260948613,0.30141428148632216,-0.05459618476215373,0.8217925949426864,-0.09523903258909394,-0.3856868930458746,-0.47055931834629494,0.30141428148632216 3193 Recurrent respiratory infections 22 124 2.085078446294617 0.037062180384666 O96028,Q9Y4P3,P04062,Q13432,Q03518,P16278,P09601,Q9NZJ7,P51798,Q9UID3,Q7Z5L9,Q9Y487,Q9H2M9,Q9BUR4,P07602,O15460,P53007,Q9BV10,Q96AX1,Q96GM5,Q07864,Q96HA7 Drugs and Diseases Human Phenotype Ontology msigdb_hp 134,411,259,14,30,33,35,167,170,339,333,73,209,78,79,201,325,235,233,379,369,125 1301,1710,927,2727,201,1150,552,740,2333,1721,555,2337,2897,1310,1156,134,2174,2968,1890,259,2253,1801,3020,79,35,1313,862,1899,2258,1465,2417,1385,2680,2996,33,2491,863,1468,2562,2623,2346,1232,2825,2565,653,2267,1236,2830,2498,1644,1735,2090,2934,657,509,1476,170,325,511,2506,1399,1247,2008,2193,2439,1322,2099,1486,1409,2574,1096,30,2365,369,392,1748,2755,1014,14,1101,1830,2281,2907,1755,886,1935,1182,1581,1762,333,1765,2458,1948,1509,1269,1115,1597,1201,233,2221,379,125,2133,1276,1957,78,235,3066,209,977,3012,1358,1526,1126,1866,465,3052,167,1783,339,919,737,73,411 0.06603905308700285,-0.13609598281271182,0.26273353937402294,-0.6863465232630938,1.0686319460690494,0.1453758906367192,0.529103559661836,0.3781352496108558,-0.4280193129695504,-0.13609598281271182,0.529103559661836,-0.4280193129695504,-0.8626367719544891,0.06603905308700285,0.1453758906367192,1.4409187687914826,-0.34356283749264765,-0.996960006644522,-0.21844879395768765,0.9285879028743135,-0.3856868930458746,-0.17716618352898394,-1.0875012711994665,1.9216366583397482,3.109740761515161,0.06603905308700285,0.30141428148632216,-0.21844879395768765,-0.3856868930458746,-0.014168302611951702,-0.47055931834629494,0.026043738945028046,-0.6427799465527326,-1.0421318380239888,3.136801573389376,-0.5133061398194652,0.30141428148632216,-0.014168302611951702,-0.5562590173955732,-0.5994172002524207,-0.4280193129695504,0.10581674080916348,-0.7740882787487618,-0.5562590173955732,0.4540235095844826,-0.3856868930458746,0.10581674080916348,-0.7740882787487618,-0.5133061398194652,-0.09523903258909394,-0.13609598281271182,-0.30164793499149467,-0.9072118013025617,0.4540235095844826,0.566347842731351,-0.014168302611951702,1.2061148609413,0.8217925949426864,0.566347842731351,-0.5133061398194652,0.026043738945028046,0.10581674080916348,-0.25994298419798034,-0.34356283749264765,-0.47055931834629494,0.06603905308700285,-0.30164793499149467,-0.014168302611951702,0.026043738945028046,-0.5562590173955732,0.1847155783283068,3.455451002526678,-0.4280193129695504,0.7497224929294436,0.7134182805889118,-0.13609598281271182,-0.6863465232630938,0.22383486656935098,4.5169784040611045,0.1847155783283068,-0.17716618352898394,-0.3856868930458746,-0.8626367719544891,-0.13609598281271182,0.30141428148632216,-0.21844879395768765,0.1453758906367192,-0.05459618476215373,-0.13609598281271182,0.8217925949426864,-0.13609598281271182,-0.47055931834629494,-0.21844879395768765,-0.014168302611951702,0.10581674080916348,0.1847155783283068,-0.05459618476215373,0.1453758906367192,0.9989383120950578,-0.34356283749264765,0.7497224929294436,1.5067209080288002,-0.30164793499149467,0.10581674080916348,-0.21844879395768765,1.9836200003720745,0.9989383120950578,-1.178830334389834,1.0686319460690494,0.26273353937402294,-1.0421318380239888,0.06603905308700285,-0.014168302611951702,0.1847155783283068,-0.17716618352898394,0.640258997817798,-1.1330676522557266,1.2401003260948613,-0.13609598281271182,0.8217925949426864,0.30141428148632216,0.41618190889414125,2.106203804691737,0.7134182805889118 3193 Golgi apparatus 63 303 2.0733375673178567 0.0381408748138891 Q9BTV4,Q9UM00,Q14108,Q12893,Q13464,O43731,P80303,P04062,Q6ZRP7,Q8NCH0,Q9BRK5,Q92544,Q9UQB8,P24390,O14828,Q13190,P16278,P50897,Q9NQX7,P46934,Q9Y3E0,Q7LGA3,Q9Y282,Q5VW38,P20645,P49327,Q02818,Q96A57,O43505,Q8IWJ2,Q10471,Q9UID3,Q96L58,Q8WWQ0,Q969E2,Q9P2W9,Q96RL7,O43852,Q15392,P56377,O14653,P04439,P53367,Q9Y3A6,Q7Z5K2,Q9HC07,Q92896,Q8TAD4,O95782,O00443,Q08AM6,O15126,Q16706,O00461,P22681,Q12959,P42858,Q8NCM8,O75503,Q7Z460,Q15042,Q93050,P35613 Localization GO Cellular component msigdb_gocc 402,410,6,136,262,139,12,259,396,398,147,146,21,22,384,393,33,43,45,169,316,308,186,52,416,54,55,459,178,456,328,339,337,336,67,467,462,322,75,327,319,202,326,361,220,89,355,354,94,211,350,212,98,100,345,103,107,375,116,374,371,252,366 636,1301,2667,2925,211,100,2892,2990,927,319,1626,2166,384,1712,2330,2481,212,550,441,3131,789,2168,505,178,2993,139,2482,1460,2069,322,2070,592,2672,1375,2552,2861,1540,116,2250,2774,1630,2775,2337,1981,1889,1155,1631,1799,698,1073,94,2733,2968,259,202,2255,3057,2898,1894,801,1898,2777,3111,1077,2778,1230,33,1386,2180,2558,416,2346,649,1388,345,22,1001,1809,2784,2495,653,2426,2786,2629,1472,366,867,1473,2428,2689,477,107,2003,169,1906,2270,874,54,1737,1090,2746,1091,657,43,1004,1909,2435,3171,3085,1560,1647,876,326,2274,2437,2506,327,2011,1822,708,1742,812,948,1093,2359,2790,2572,813,1915,711,12,514,2444,2959,1745,2574,1917,55,2447,350,328,2698,661,1749,136,2017,567,2367,103,393,2699,262,2577,1015,2514,2023,3160,6,2280,1259,2700,608,1179,1930,3174,1665,371,2879,3088,885,75,2701,2376,98,3164,573,52,1027,1028,2032,1029,2292,2587,396,1420,308,2121,1266,374,220,2296,1504,2035,2961,1191,1945,2299,456,1679,1110,1506,764,1847,2520,398,375,1111,354,970,1593,3045,2708,1950,3181,671,1849,336,1198,2039,146,1270,355,1035,252,67,1273,3028,459,337,2303,2304,462,771,2135,772,2396,906,2137,3047,2803,147,1692,402,1958,2918,3010,535,2050,1356,3120,3135,1608,1960,628,1776,1609,1126,2313,2920,89,1700,583,45,1611,1443,1613,1049,846,1212,916,467,2470,984,1618,985,339,2321,2536,2989,2538,410,922,2061,2664,1366,633,21,3071,186,781,2855,2244,2157,2923,3082,1532,361,547,316,588,2542,2326,635 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3193 SLC superfamily of solute carriers 17 44 2.0661382223420404 0.0388154300658385 Q70HW3,Q9HC07,Q8IXU6,P53985,Q9NZJ7,Q9BQT8,Q9UBX3,Q9Y6C9,Q9H2D1,Q6N075,P53007,Q99808,Q7L0J3,Q9Y6M7,O43772,Q9Y619,O75746 Drugs and Diseases Pharos Drug Target Ontology pharos_dto 64,89,36,102,167,109,110,128,50,172,325,289,88,25,26,92,243 26,638,243,555,1074,1464,2778,1161,647,1733,325,102,877,1655,952,884,1580,172,2517,1187,64,88,36,354,970,1039,289,109,623,1043,3066,50,1698,2051,1358,1865,89,841,167,110,502,92,128,25 3.481516904512842,0.4540235095844826,0.9638462735845957,0.529103559661836,0.1847155783283068,-0.014168302611951702,-0.7301162059779877,0.1453758906367192,0.4540235095844826,-0.13609598281271182,0.8217925949426864,1.6688607961699844,0.30141428148632216,-0.09523903258909394,0.26273353937402294,0.30141428148632216,-0.05459618476215373,1.2061148609413,-0.5133061398194652,0.1453758906367192,2.2867598270374043,1.8277698868878607,2.973209044321641,0.7858464474140958,0.26273353937402294,0.22383486656935098,0.8931610038007228,1.6044026869650967,0.49166307589473773,0.22383486656935098,-1.178830334389834,2.579393242759746,-0.09523903258909394,-0.25994298419798034,0.06603905308700285,-0.17716618352898394,1.8277698868878607,0.33988043265628903,1.2401003260948613,1.6044026869650967,0.603398739242378,1.7962380654131864,1.5067209080288002,3.5592823972272063 3193 Aplasia hypoplasia involving the femoral head and neck 6 10 2.0606295302935784 0.0393383972683922 Q96L58,Q96HY6,O95831,Q96HA7,Q99575,O00443 Drugs and Diseases Human Phenotype Ontology msigdb_hp 337,223,58,125,530,211 211,1069,58,609,1849,125,223,337,530,1963 1.033866168077631,0.1847155783283068,2.4343271247364595,0.49166307589473773,-0.17716618352898394,1.5067209080288002,1.033866168077631,0.8217925949426864,0.566347842731351,-0.21844879395768765 3193 Reduced consciousness confusion 26 128 2.052687755646757 0.0401028703275165 Q9NZ08,Q96CU9,P04062,P23378,P49748,Q12756,O43772,P61313,Q9Y6M9,Q9NZJ7,O43676,P49770,Q96RR1,P49327,Q13423,P07602,P35610,Q9Y619,O75306,P05165,P42858,P40818,P54098,P31751,P08397,P50747 Drugs and Diseases Human Phenotype Ontology msigdb_hp 133,9,259,144,148,392,26,161,438,167,46,420,183,54,77,79,84,92,97,342,107,226,114,365,364,244 1877,3175,412,3032,2727,46,694,26,640,1068,97,998,1888,800,1380,699,2968,259,3057,342,1075,79,364,1897,802,1804,2778,1724,1161,1727,3095,863,804,2561,1468,2082,595,1078,144,650,2349,651,1469,2265,2625,1003,365,805,2744,84,2427,1556,1642,2352,3097,2498,226,1084,1238,1558,107,1394,2933,2901,54,148,420,1242,2091,2633,749,244,114,1477,707,2193,1823,161,1401,1005,2012,1173,710,2197,1565,1483,3150,660,392,2755,1411,77,2024,1497,663,759,2846,2798,616,2915,2799,2461,1201,9,831,1686,578,183,1280,1518,1206,1358,841,2655,1866,732,1529,133,167,687,631,1134,502,1297,2406,92,1217,438 -0.21844879395768765,-2.537457890708034,0.6769313036646232,-1.1330676522557266,-0.6863465232630938,2.6081164823979903,0.41618190889414125,3.481516904512842,0.4540235095844826,0.1847155783283068,1.7328021609675641,0.22383486656935098,-0.21844879395768765,0.33988043265628903,0.026043738945028046,0.41618190889414125,-0.996960006644522,0.9285879028743135,-1.178830334389834,0.7858464474140958,0.1847155783283068,1.9216366583397482,0.7497224929294436,-0.21844879395768765,0.33988043265628903,-0.17716618352898394,-0.7301162059779877,-0.13609598281271182,0.1453758906367192,-0.13609598281271182,-1.3172898231999288,0.30141428148632216,0.33988043265628903,-0.5562590173955732,-0.014168302611951702,-0.30164793499149467,0.49166307589473773,0.1847155783283068,1.3745569471497667,0.4540235095844826,-0.4280193129695504,0.4540235095844826,-0.014168302611951702,-0.3856868930458746,-0.5994172002524207,0.22383486656935098,0.7497224929294436,0.33988043265628903,-0.6863465232630938,1.8591793954863818,-0.47055931834629494,-0.05459618476215373,-0.09523903258909394,-0.4280193129695504,-1.3172898231999288,-0.5133061398194652,0.9989383120950578,0.1847155783283068,0.10581674080916348,-0.05459618476215373,1.6044026869650967,0.026043738945028046,-0.9072118013025617,-0.8626367719544891,2.4926471507031023,1.3411620038373298,0.6769313036646232,0.10581674080916348,-0.30164793499149467,-0.5994172002524207,0.3781352496108558,0.9638462735845957,1.5719762130717865,-0.014168302611951702,0.41618190889414125,-0.34356283749264765,-0.17716618352898394,1.2401003260948613,0.026043738945028046,0.22383486656935098,-0.25994298419798034,0.1453758906367192,0.41618190889414125,-0.34356283749264765,-0.05459618476215373,-0.014168302611951702,-1.839773156881485,0.4540235095844826,0.7134182805889118,-0.6863465232630938,0.026043738945028046,1.9836200003720745,-0.25994298419798034,-0.014168302611951702,0.4540235095844826,0.3781352496108558,-0.7740882787487618,-0.7301162059779877,0.49166307589473773,-0.8626367719544891,-0.7301162059779877,-0.47055931834629494,0.1453758906367192,5.58392652742442,0.33988043265628903,-0.09523903258909394,0.529103559661836,1.1719772075302926,0.10581674080916348,-0.014168302611951702,0.1453758906367192,0.06603905308700285,0.33988043265628903,-0.5994172002524207,-0.17716618352898394,0.41618190889414125,-0.014168302611951702,1.4738889842432312,1.2401003260948613,0.4540235095844826,0.49166307589473773,0.1847155783283068,0.603398739242378,0.10581674080916348,-0.4280193129695504,1.7962380654131864,0.1453758906367192,0.6769313036646232 3193 Lipid biosynthetic process 32 137 2.039294698456747 0.0414206244450801 Q96BW9,P11413,P04062,O00154,Q5T2R2,Q9NPH0,P49748,Q15800,Q9HCL2,O95864,Q8NBX0,Q92604,Q06136,Q86YN1,Q8WTV0,P30536,P49327,Q9BZF3,P35790,Q96G23,P04035,Q8NCC3,Q15392,Q16880,P35610,Q92643,Q14739,O00443,O75845,Q16850,Q9UKR5,P48449 Processes and pathways GO Biological process msigdb_gobp 264,261,259,256,145,20,148,150,151,153,27,286,31,309,51,53,54,62,61,65,194,74,75,86,84,222,91,211,105,115,127,121 1218,256,211,2546,2329,471,320,692,851,996,3154,506,1067,2774,105,1154,2336,2171,799,698,859,2822,153,2733,645,194,259,2928,2255,3158,1076,261,1160,2680,2972,2420,3183,935,2491,1386,1388,1080,700,2349,743,2826,53,2087,84,61,1237,561,477,2500,121,2902,54,148,2191,1397,512,2903,3133,2574,31,350,661,2576,1101,1832,1259,2282,91,1260,1931,2842,2756,75,1934,962,758,150,2288,115,86,2116,427,1414,145,668,3163,892,309,2124,721,27,74,1111,310,51,768,3119,286,222,2219,264,65,2394,2395,2306,2397,906,1692,3191,3180,2885,403,1695,62,3135,2887,628,151,20,1527,1613,2597,846,1131,3014,916,984,631,1618,1784,127,1365 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3193 Chemical homeostasis 25 182 2.034164066917727 0.0419350561721543 Q15120,P30519,P42785,P04062,Q92544,Q5BJF2,Q9HCL2,Q9Y6M7,P09601,P50897,Q8WTV0,P30536,Q96RR1,Q9HD20,Q9Y487,P35610,Q7L0J3,Q9HC07,Q93050,P53985,Q96AX1,Q5SW96,P42858,O75503,Q9Y6C9 Processes and pathways GO Biological process msigdb_gobp 131,7,10,259,146,23,151,25,35,43,51,53,183,59,73,84,88,89,252,102,233,229,107,116,128 1879,1301,412,2546,1145,927,2991,2481,788,3131,640,2673,1150,641,116,2335,2611,856,2926,555,1889,1155,1228,1722,1890,259,3073,1632,2255,3167,3057,2073,2488,1986,2176,3158,2929,1895,593,1076,35,1545,3111,2076,1726,2259,2420,1805,2491,3084,2421,2261,2179,1467,1806,2181,649,1388,2784,3096,2495,652,653,2267,7,53,2998,3188,84,2630,2498,1735,10,107,2934,1396,1086,43,1004,509,2435,3171,2693,1648,102,1169,877,1479,1402,2754,563,2098,1484,711,2837,1743,2276,2959,1657,1919,1488,2199,2755,1749,2367,2576,2577,480,3040,452,883,884,819,131,1755,2879,1936,1757,2515,571,2288,1330,23,229,1417,667,3062,88,2458,893,1109,2798,3065,824,1948,3128,766,1683,1111,354,51,2460,146,252,1117,233,902,183,1690,2045,2047,289,2309,1435,1043,3048,2850,582,977,1863,1438,89,151,59,1441,537,982,2769,3014,1617,1618,2854,1706,1707,410,1059,73,1535,2604,2407,128,25 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3193 Mitochondrial carrier domain superfamily [IPR023395] 9 21 2.031106355543621 0.0422442068889223 Q70HW3,Q9NZJ7,Q9BQT8,Q9UBX3,Q9H2D1,Q9Y6C9,O43772,Q9Y619,O75746 Sequence InterPro Superfamily interpro_homologous_superfamily 64,167,109,110,50,128,26,92,243 26,638,243,1074,1161,647,325,1655,952,2517,64,109,623,50,1358,841,167,110,502,92,128 3.481516904512842,0.4540235095844826,0.9638462735845957,0.1847155783283068,0.1453758906367192,0.4540235095844826,0.8217925949426864,-0.09523903258909394,0.26273353937402294,-0.5133061398194652,2.2867598270374043,1.6044026869650967,0.49166307589473773,2.579393242759746,0.06603905308700285,0.33988043265628903,1.2401003260948613,1.6044026869650967,0.603398739242378,1.7962380654131864,1.5067209080288002 3193 Mitochondrial substrate/solute carrier [IPR018108] 9 21 2.031106355543621 0.0422442068889223 Q70HW3,Q9NZJ7,Q9BQT8,Q9UBX3,Q9H2D1,Q9Y6C9,O43772,Q9Y619,O75746 Sequence InterPro Repeat interpro_repeat 64,167,109,110,50,128,26,92,243 26,638,243,1074,1161,647,325,1655,952,2517,64,109,623,50,1358,841,167,110,502,92,128 3.481516904512842,0.4540235095844826,0.9638462735845957,0.1847155783283068,0.1453758906367192,0.4540235095844826,0.8217925949426864,-0.09523903258909394,0.26273353937402294,-0.5133061398194652,2.2867598270374043,1.6044026869650967,0.49166307589473773,2.579393242759746,0.06603905308700285,0.33988043265628903,1.2401003260948613,1.6044026869650967,0.603398739242378,1.7962380654131864,1.5067209080288002 3193 SLC25 family of mitochondrial transporters 9 21 2.031106355543621 0.0422442068889223 Q70HW3,Q9NZJ7,Q9BQT8,Q9UBX3,Q9H2D1,Q9Y6C9,O43772,Q9Y619,O75746 Drugs and Diseases Pharos Drug Target Ontology pharos_dto 64,167,109,110,50,128,26,92,243 26,638,243,1074,1161,647,325,1655,952,2517,64,109,623,50,1358,841,167,110,502,92,128 3.481516904512842,0.4540235095844826,0.9638462735845957,0.1847155783283068,0.1453758906367192,0.4540235095844826,0.8217925949426864,-0.09523903258909394,0.26273353937402294,-0.5133061398194652,2.2867598270374043,1.6044026869650967,0.49166307589473773,2.579393242759746,0.06603905308700285,0.33988043265628903,1.2401003260948613,1.6044026869650967,0.603398739242378,1.7962380654131864,1.5067209080288002 3193 Abnormality of upper limb joint 23 114 2.0163593882271704 0.0437624089556412 Q9BTV4,O96028,Q9Y4P3,P10644,P16278,Q03164,P07196,Q9H1A4,Q7LGA3,O95831,P42892,Q96L58,Q9NR77,O75844,Q15392,Q9Y619,O00443,P22681,Q9BV10,P50402,Q15042,Q96HA7,Q15022 Drugs and Diseases Human Phenotype Ontology msigdb_hp 402,134,411,260,33,163,274,176,308,58,188,337,66,68,75,92,211,345,235,348,371,125,370 2163,211,2164,2727,3072,1886,1303,2672,1976,2484,1222,1462,68,2171,1227,555,58,134,2175,3020,274,260,1899,1465,33,935,2179,863,2346,2624,345,650,1001,557,653,2830,2428,1642,1237,1238,1644,188,2090,2902,348,1476,1248,1911,1823,2790,2195,2099,2574,1917,1096,163,1488,1175,1014,2839,1101,2279,3040,1497,1833,370,1180,371,2907,1931,1329,75,1933,1666,1762,1763,2209,1420,308,2706,1110,1509,1594,1849,826,1272,672,125,2133,337,577,3007,1600,1518,530,1041,402,235,2766,176,1129,1963,66,434,919,2922,779,1623,1452,411,2066,92,993,784 -0.34356283749264765,1.033866168077631,-0.34356283749264765,-0.6863465232630938,-1.2247886777807828,-0.21844879395768765,0.06603905308700285,-0.6427799465527326,-0.25994298419798034,-0.5133061398194652,0.10581674080916348,-0.014168302611951702,2.1365684786427637,-0.34356283749264765,0.10581674080916348,0.529103559661836,2.4343271247364595,1.4409187687914826,-0.34356283749264765,-1.0875012711994665,0.8931610038007228,0.9285879028743135,-0.21844879395768765,-0.014168302611951702,3.136801573389376,0.26273353937402294,-0.34356283749264765,0.30141428148632216,-0.4280193129695504,-0.5994172002524207,0.7858464474140958,0.4540235095844826,0.22383486656935098,0.529103559661836,0.4540235095844826,-0.7740882787487618,-0.47055931834629494,-0.09523903258909394,0.10581674080916348,0.10581674080916348,-0.09523903258909394,1.1376854683380586,-0.30164793499149467,-0.8626367719544891,0.7858464474140958,-0.014168302611951702,0.10581674080916348,-0.21844879395768765,-0.17716618352898394,-0.7301162059779877,-0.34356283749264765,-0.30164793499149467,-0.5562590173955732,-0.21844879395768765,0.1847155783283068,1.2401003260948613,-0.014168302611951702,0.1453758906367192,0.22383486656935098,-0.7740882787487618,0.1847155783283068,-0.3856868930458746,-1.1330676522557266,-0.014168302611951702,-0.17716618352898394,0.7497224929294436,0.1453758906367192,0.7497224929294436,-0.8626367719544891,-0.21844879395768765,0.06603905308700285,2.045139224212076,-0.21844879395768765,-0.09523903258909394,-0.13609598281271182,-0.13609598281271182,-0.34356283749264765,0.026043738945028046,0.8575633322997649,-0.6427799465527326,0.1847155783283068,-0.014168302611951702,-0.05459618476215373,-0.17716618352898394,0.33988043265628903,0.10581674080916348,0.4540235095844826,1.5067209080288002,-0.30164793499149467,0.8217925949426864,0.529103559661836,-1.0421318380239888,-0.05459618476215373,-0.014168302611951702,0.566347842731351,0.22383486656935098,0.7134182805889118,0.9989383120950578,-0.6863465232630938,1.2061148609413,0.1847155783283068,-0.21844879395768765,2.1969681791216726,0.6769313036646232,0.30141428148632216,-0.8626367719544891,0.3781352496108558,-0.05459618476215373,0.026043738945028046,0.7134182805889118,-0.25994298419798034,1.7962380654131864,0.26273353937402294,0.3781352496108558 3193 Hepatomegaly 23 170 2.006101173107365 0.0448454547343122 Q14108,Q96CU9,P49748,O43772,P16278,P09601,Q9NZJ7,P51798,O43676,P49327,Q9BUR4,P07602,P35610,Q96HY6,Q9HC07,Q14739,Q9Y619,O00443,O75306,Q96AX1,O75845,P54098,O75648 Drugs and Diseases Human Phenotype Ontology msigdb_hp 6,9,148,26,33,35,167,170,46,54,78,79,84,223,89,91,92,211,97,233,105,114,242 1301,3175,211,3032,927,2481,2951,46,26,1067,552,1068,97,796,998,797,1069,1888,1153,242,1378,105,2335,2821,2337,1310,1311,2175,259,2253,342,1075,1986,1801,79,3158,1544,35,1804,862,2778,1724,344,1385,1727,2680,1547,2868,2996,33,1162,2561,2082,2623,2182,1078,345,650,2349,2495,558,743,2625,652,2827,365,1236,2999,805,1393,84,2427,1556,1557,2352,3190,2690,1084,1905,2934,54,2356,148,2091,749,2872,1245,170,325,511,114,1910,1247,2749,2095,2439,1402,2790,2100,514,1567,1488,754,661,3024,1101,1830,1102,6,2281,2372,91,819,2113,1936,663,2795,2645,2289,1415,889,717,2797,2121,1585,2798,1033,2799,2709,2461,899,1117,233,900,9,831,223,2133,462,1119,2395,1280,624,1206,78,3066,1126,89,841,1866,912,982,1529,3052,167,687,1966,436,918,502,737,2476,1451,923,1214,3016,1452,1368,92,438 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3193 Abnormal upper limb bone morphology 23 101 1.9972266977342492 0.045800562099274 Q15022,O96028,Q9Y4P3,P10644,P16278,Q9H1A4,P51798,Q7LGA3,Q96L58,O75844,Q08J23,Q9H2M9,Q9UHX1,Q14739,Q08AM6,P22681,Q9BV10,P42858,Q32P28,Q8NCM8,Q96HA7,O75648,O15360 Drugs and Diseases Human Phenotype Ontology msigdb_hp 370,134,411,260,33,176,170,308,337,68,205,209,83,91,350,345,235,107,248,375,125,242,119 1218,2163,2727,692,119,1886,3173,1976,2484,1069,1462,1307,242,68,555,2486,134,2175,260,33,935,2179,2346,345,1001,2264,2830,2428,1642,561,2430,3097,107,2902,170,1739,511,2506,877,1823,2790,2099,2445,1917,1488,350,205,392,1175,1014,1664,1575,1497,91,1833,370,2907,1329,1933,1666,248,1762,1763,2517,3089,2209,1420,308,1504,1032,375,1509,1849,1951,1597,2219,672,1036,125,337,577,2395,2594,235,2849,176,209,977,1210,1126,2148,2658,631,83,919,2922,545,1623,781,411,2066 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3193 Abnormal vertebral morphology 24 107 1.9884756433646924 0.0467591101633471 Q9UM00,Q14108,Q9NSE4,O96028,Q9Y4P3,P10644,P04062,Q8NCH0,O75718,P16278,P51798,O95831,Q96L58,Q9UHX1,Q96HY6,P10619,Q14739,Q9Y619,Q9BV10,O75845,P40818,Q32P28,Q8NCM8,Q96HA7 Drugs and Diseases Human Phenotype Ontology msigdb_hp 410,6,407,134,411,260,259,398,385,33,170,58,337,83,223,90,91,92,235,105,226,248,375,125 3056,2164,3032,2727,692,2951,1886,1794,2672,1150,2484,385,105,1154,555,58,134,259,2253,861,90,260,2679,2996,33,935,864,2182,2346,1729,1001,1810,2830,1473,1642,2831,3097,226,2632,1244,170,1739,1247,1911,2439,1172,1916,2099,2014,2100,2574,1096,661,1748,1493,1014,6,960,91,1833,2907,1931,1933,2701,758,248,2289,1667,1762,2517,889,1105,2797,1108,1678,616,398,375,2709,3181,1849,672,2221,125,223,2133,337,577,530,235,3012,1126,1963,407,434,2148,631,83,919,410,1451,1708,3016,411,2066,92,993 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3193 Reduced visual acuity 14 115 1.983890270849051 0.0472680737554664 P16278,O75306,Q9NZ08,Q9NZJ7,P53701,Q96CU9,P50897,P51798,O43676,P07602,P54098,Q9UHX1,P49327,Q9H061 Drugs and Diseases Human Phenotype Ontology msigdb_hp 33,97,133,167,135,9,43,170,46,79,114,83,54,126 1877,1062,3056,1301,3175,2925,2546,1792,852,442,178,46,694,1537,1461,1068,97,998,1888,1070,1630,553,2864,2968,2414,3075,3033,79,3158,1987,1897,1804,1634,1723,1899,3095,33,2179,2780,1806,2561,2423,2346,1315,700,1001,2625,745,2742,805,867,1473,1642,1238,54,420,2091,1243,43,170,1740,135,114,2193,708,709,2790,1653,2574,1096,754,661,2755,1411,3024,2839,2024,884,482,1756,890,2209,1675,2458,1678,2798,2799,1344,896,1035,1201,9,771,974,1280,1519,2397,2224,1206,126,977,1866,732,1529,133,167,687,1618,83,1134,779,3093,1535,1299,438 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3193 Abnormality of the curvature of the vertebral column 75 315 1.97680163603153 0.0480640567066827 Q15022,Q9BTV4,Q9UM00,Q14108,Q9NSE4,Q96CU9,O96028,Q9Y4P3,P10644,Q99720,P04062,Q8NCH0,Q8NBU5,O75718,Q9UPQ9,P51532,Q12756,P55795,Q8NFF5,P16278,Q96RT7,Q9NUQ7,P07196,Q9BUK6,Q96L73,Q7LGA3,Q9NP72,Q9Y4A5,O95831,P27635,Q96GW9,O60832,Q96L58,Q9NR77,O95202,O75844,P09651,Q00839,Q9Y487,Q08J23,Q9H2M9,P56377,O14653,P38398,Q9BUR4,Q9BT22,P53007,Q9UHX1,Q14331,Q96HY6,Q9HC07,Q14739,Q2TAA5,O00443,P22681,Q9BV10,Q9BQT8,Q96AX1,P50402,Q99575,P42858,Q96GM5,P40818,Q32P28,Q8NCM8,Q6ZXV5,P22626,Q15042,Q07864,P82930,Q15437,Q96HA7,P48449,O75648,O15360 Drugs and Diseases Human Phenotype Ontology msigdb_hp 370,402,410,6,407,9,134,411,260,13,259,398,263,385,545,509,392,513,429,33,432,434,274,313,577,308,583,588,58,557,461,552,337,66,555,68,556,565,73,205,209,327,319,561,78,624,325,83,451,223,89,91,217,211,345,235,109,233,348,530,107,379,226,248,375,373,476,371,369,368,483,125,121,242,119 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3193