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1761, 609, 1000, 2256, 2605, 263, 2734, 916, 2643, 242, 611, 1085, 2926, 2319, 2258, 1257, 1607, 1911, 83, 1835, 3000, 1172, 2492, 1535, 2493, 2430, 2693, 2260, 2198, 1472, 2261, 367, 2371, 612, 447, 1837, 3165, 919, 2128, 1259, 782, 341, 2869, 658, 2984, 412, 1175, 3071, 2738, 313, 3168, 3185, 1176, 220, 2496, 2497, 3072, 3102, 1261, 2645, 1178, 1687, 1984, 1090, 2739, 3108, 368, 266, 14, 2695, 844, 2907, 921, 2320, 413, 1005, 615, 2870, 2265, 723, 2321, 2433, 3019, 2607, 1092, 2201, 2132, 1842, 1342, 2742, 2773, 152, 1412, 2063, 2609, 2322, 1540, 2323, 2872, 3021, 2985, 2775, 1541, 2610, 1476, 2375, 2648, 267, 2205, 1917, 1766, 451, 2206, 504, 785, 2697, 1614, 2269, 2874, 3001, 1543, 369, 1986, 851, 1987, 2325, 1414, 1010, 3159, 2134, 1544, 1617, 1768, 370, 2436, 1480, 1618, 1481, 2777, 2613, 2326, 2698, 2327, 2549, 1691, 1265, 1482, 928, 662, 2927, 129, 618, 93, 33, 2209, 2072, 2137, 1013, 1268, 2074, 929, 1695, 315, 854, 2502, 2271, 2954, 1348, 3079, 3177, 508, 3002, 1485, 3042, 619, 2699, 222, 2616, 2822, 2957, 2700, 99, 1625, 666, 2651, 2273, 1350, 934, 2379, 2438, 2504, 1851, 155, 510, 3003, 1107, 268, 371, 936, 2823, 1629, 198, 1993, 3096, 456, 2824, 2747, 2213, 459, 1852, 3023, 622, 563, 564, 3024, 2275, 2782, 296, 860, 1700, 1994, 2618, 624, 2557, 2080, 2508, 1854, 157, 2929, 1275, 2214, 2653, 732, 1546, 1016, 2509, 2619, 271, 272, 2784, 2654, 2329, 1774, 1356, 2785, 3153, 2829, 2559, 2330, 2655, 1020, 2382, 2277, 1702, 2331, 1632, 1195, 2146, 2279, 374, 1196, 627, 1421, 1198, 2561, 1278, 736, 1360, 225, 1998, 940, 2219, 463, 1858, 1930, 2147, 2962, 628, 2282, 2877, 298, 1549, 1706, 1423, 2787, 514, 1491, 566, 1365, 2987, 1366, 2384, 2512, 2333, 2513, 2909, 3119, 3129, 1860, 1283, 739, 2789, 2705, 798, 184, 2622, 2445, 3141, 1637, 3132, 3004, 2087, 2446, 1709, 2088, 799, 2385, 158, 3059, 185, 3186, 2830, 3170, 1712, 202, 941, 2707, 251, 2283, 1784, 3171, 424, 1425, 2089, 1785, 3180, 1426, 86, 3005, 2152, 3029, 2285, 865, 1558, 2334, 2963, 3112, 2931, 227, 800, 1640, 1714, 1561, 2750, 2337, 1863, 2835, 228, 3097, 1029, 2624, 571, 382, 745, 1289, 2914, 1716, 1372, 2222, 1202, 2711, 2568, 3187, 2880, 2223, 805, 1717, 746, 2516, 747, 2009, 3082, 1204, 2569, 2660, 3061, 2752, 678, 383, 3006, 427, 2010, 867, 1641, 2837, 2394, 2092, 2517, 2450, 632, 1428, 2915, 324, 949, 868, 1865, 1429, 3047, 749, 1796]}}, "Phosphatase activity": {"direction": "up", "overlap": {"value": 35, "mean": 13.145631067961164, "std": 6.712772591402836, "bin": {"bin_50": 3, "bin_100": 5, "bin_250": 9, "bin_500": 15}}, "setsize": {"value": 60, "mean": 51.94174757281554, "std": 8.480503331277838, "bin": {"bin_50": 199, "bin_100": 199, "bin_250": 199, "bin_500": 199}}, "score": {"value": 3.1913123809064143, "mean": -0.2136566108287436, "std": 1.0011340610450716, "bin": {"bin_50": 3.385034013605442, "bin_100": 2.744706795255515, "bin_250": 1.9339792997137195, "bin_500": 1.6057926005941128}}, "pval": {"value": 0.0014162806201589, "mean": 0.5782522454352085, "std": 0.3419346460390784, "bin": {"bin_50": 0.0668087997235459, "bin_100": 0.0426118271714143, "bin_250": 0.054069286658579, "bin_500": 0.0628473887263958}}, "signature_idxs": {"edge": [801, 670, 262, 257, 555, 156, 20, 394, 565, 25, 33, 645, 905, 526, 848, 180, 48, 858, 53, 861, 309, 603, 198, 606, 690, 506, 834, 334, 595, 114, 946, 359, 660, 794, 795], "full": [53, 526, 1121, 3098, 2663, 257, 2715, 2353, 2297, 394, 690, 1955, 645, 1663, 359, 262, 595, 902, 25, 1150, 334, 905, 1891, 2683, 309, 834, 2483, 2538, 603, 48, 1469, 555, 1327, 606, 114, 3057, 1095, 660, 848, 180, 506, 33, 1620, 2953, 1624, 20, 156, 858, 198, 861, 794, 670, 1489, 1194, 795, 565, 2749, 2710, 801, 946]}}, "Ligase activity forming carbon carbon bonds": {"direction": "dw", "overlap": {"value": 5, "mean": 4.62378640776699, "std": 1.1519157673028364, "bin": {}}, "setsize": {"value": 7, "mean": 6.856796116504855, "std": 0.3502806464066411, "bin": {}}, "score": {"value": -2.982074444722689, "mean": -2.028273173745319, "std": 1.451790697844621, "bin": {}}, "pval": {"value": 0.0028630237117415, "mean": 0.0966053788189329, "std": 0.2179146178607854, "bin": {}}, "signature_idxs": {"edge": [3169, 3189, 3190, 3083, 3160], "full": [3083, 3160, 1577, 3190, 3189, 3169, 1358]}}, "Cysteine type peptidase activity": {"direction": "up", "overlap": {"value": 29, "mean": 12.109223300970871, "std": 6.000017182713323, "bin": {"bin_50": 2, "bin_100": 3, "bin_250": 7, "bin_500": 17}}, "setsize": {"value": 53, "mean": 44.08495145631068, "std": 7.277780171243459, "bin": {"bin_50": 141, "bin_100": 141, "bin_250": 141, "bin_500": 141}}, "score": {"value": 2.977511400928986, "mean": -0.1451192974466758, "std": 0.8950128681796422, "bin": {"bin_50": 3.1307475758523617, "bin_100": 2.279176201372998, "bin_250": 2.127268223199356, "bin_500": 2.728824357856616}}, "pval": {"value": 0.0029059883636914, "mean": 0.596001868152635, "std": 0.3160523160059556, "bin": {"bin_50": 0.142225435971089, "bin_100": 0.1539610702624851, "bin_250": 0.0563879799682196, "bin_500": 0.000500693334807}}, "signature_idxs": {"edge": [489, 5, 802, 911, 31, 729, 843, 324, 613, 735, 192, 348, 439, 337, 84, 230, 697, 497, 370, 825, 518, 246, 790, 481, 912, 357, 134, 661, 482], "full": [871, 1866, 1497, 1940, 230, 1437, 2233, 1215, 1439, 357, 2671, 2038, 481, 31, 697, 482, 825, 1670, 192, 439, 5, 337, 1075, 489, 911, 912, 1681, 2254, 497, 1911, 613, 843, 2871, 1616, 729, 2435, 370, 1345, 1689, 661, 84, 2377, 246, 790, 2786, 348, 735, 1023, 3059, 518, 802, 134, 324]}}, "Phosphoric ester hydrolase activity": {"direction": "up", "overlap": {"value": 37, "mean": 13.983009708737864, "std": 7.163296596269021, "bin": {"bin_50": 4, "bin_100": 6, "bin_250": 12, "bin_500": 18}}, "setsize": {"value": 72, "mean": 63.310679611650485, "std": 9.21904858538458, "bin": {"bin_50": 250, "bin_100": 250, "bin_250": 250, "bin_500": 250}}, "score": {"value": 2.781819264530045, "mean": 0.0419549724534753, "std": 0.8993707212934827, "bin": {"bin_50": 3.659275683665928, "bin_100": 2.6338203848895225, "bin_250": 2.0744908132744624, "bin_500": 1.5300646551724135}}, "pval": {"value": 0.0054055133850319, "mean": 0.6140737111070494, "std": 0.3266109107762958, "bin": {"bin_50": 0.0295630651540025, "bin_100": 0.0331776056462107, "bin_250": 0.0191538875457689, "bin_500": 0.0640183875781768}}, "signature_idxs": {"edge": [801, 670, 262, 560, 137, 257, 555, 156, 20, 394, 565, 25, 33, 645, 36, 526, 848, 180, 48, 858, 53, 861, 309, 603, 198, 867, 606, 690, 506, 334, 595, 114, 231, 359, 660, 794, 795], "full": [53, 526, 1121, 3098, 2663, 231, 257, 2715, 1728, 1502, 2353, 2297, 394, 1219, 690, 137, 1955, 2671, 645, 1663, 359, 262, 595, 902, 25, 1150, 334, 905, 1891, 36, 2683, 309, 834, 2483, 2538, 603, 48, 1469, 555, 1327, 997, 606, 114, 560, 2741, 3057, 1095, 660, 848, 180, 506, 33, 1620, 2953, 1624, 20, 156, 858, 198, 861, 794, 670, 1489, 1194, 795, 565, 2749, 2910, 2710, 801, 946, 867]}}, "Endopeptidase activity": {"direction": "up", "overlap": {"value": 25, "mean": 19.08495145631068, "std": 5.629332570724372, "bin": {"bin_50": 2, "bin_100": 2, "bin_250": 8, "bin_500": 16}}, "setsize": {"value": 61, "mean": 62.800970873786405, "std": 6.156865220927466, "bin": {"bin_50": 166, "bin_100": 166, "bin_250": 166, "bin_500": 166}}, "score": {"value": 2.593860118485063, "mean": 1.5604938505680932, "std": 1.27979578418692, "bin": {"bin_50": 2.646871686108166, "bin_100": 1.2619410569105691, "bin_250": 2.0654008438818567, "bin_500": 2.1129737206085752}}, "pval": {"value": 0.0094905090801162, "mean": 0.2935756148549138, "std": 0.359984229645684, "bin": {"bin_50": 0.1837128011128787, "bin_100": 0.4761179790057352, "bin_250": 0.0497215146092071, "bin_500": 0.0071598798551416}}, "signature_idxs": {"edge": [5, 408, 802, 31, 731, 398, 397, 843, 171, 192, 814, 439, 813, 230, 697, 370, 826, 250, 246, 914, 481, 111, 912, 357, 134], "full": [1566, 1940, 1431, 2017, 2714, 230, 2233, 1215, 1439, 1050, 1732, 357, 1505, 2177, 171, 1660, 1508, 813, 814, 2671, 2919, 2038, 481, 31, 697, 397, 111, 398, 826, 1670, 192, 439, 5, 1065, 2483, 911, 912, 1681, 914, 1906, 2255, 408, 843, 2871, 1915, 1616, 370, 1345, 1689, 2377, 246, 2617, 1349, 731, 2140, 2081, 250, 3059, 802, 134, 1718]}}, "U1 snrna binding": {"direction": "dw", "overlap": {"value": 3, "mean": 3.4199029126213594, "std": 1.5409907260455875, "bin": {}}, "setsize": {"value": 6, "mean": 6.813106796116505, "std": 0.3898257741936229, "bin": {}}, "score": {"value": -2.591318967130469, "mean": -0.738248159873957, "std": 0.7724819425228003, "bin": {}}, "pval": {"value": 0.0095608829807343, "mean": 0.438849854938862, "std": 0.2927899286587005, "bin": {}}, "signature_idxs": {"edge": [3144, 3196, 3032], "full": [2028, 3196, 3144, 3032, 1911, 1476]}}, "Magnesium ion binding": {"direction": "up", "overlap": {"value": 31, "mean": 21.71359223300971, "std": 10.953144235755325, "bin": {"bin_50": 2, "bin_100": 4, "bin_250": 11, "bin_500": 20}}, "setsize": {"value": 77, "mean": 72.79368932038835, "std": 6.885940296543083, "bin": {"bin_50": 180, "bin_100": 180, "bin_250": 180, "bin_500": 180}}, "score": {"value": 2.578558351285312, "mean": -0.6147406093040623, "std": 1.1504366681720746, "bin": {"bin_50": 2.435271128480704, "bin_100": 2.398936170212766, "bin_250": 2.685666491898235, "bin_500": 2.4942468619246863}}, "pval": {"value": 0.0099213541864715, "mean": 0.4604947617504717, "std": 0.3542485598642225, "bin": {"bin_50": 0.2076797773569466, "bin_100": 0.0950543074669481, "bin_250": 0.0044931757541624, "bin_500": 0.0004903569518787}}, "signature_idxs": {"edge": [127, 3, 670, 289, 149, 33, 548, 288, 647, 276, 286, 531, 458, 743, 53, 305, 67, 740, 190, 222, 506, 328, 205, 578, 580, 234, 231, 593, 591, 353, 479], "full": [1374, 1430, 53, 205, 3065, 353, 2990, 1433, 1211, 531, 231, 190, 578, 1951, 580, 2991, 305, 3052, 1135, 761, 276, 884, 1307, 328, 1955, 1739, 479, 2036, 694, 895, 818, 234, 973, 1226, 591, 647, 1229, 1884, 593, 3133, 1062, 1315, 548, 1152, 149, 1071, 127, 286, 2484, 288, 289, 67, 2541, 997, 2198, 2262, 506, 33, 1101, 1620, 1989, 222, 458, 1356, 670, 3, 1705, 1423, 1780, 2513, 1283, 740, 2386, 743, 1557, 2963, 1291]}}, "Biotin binding": {"direction": "dw", "overlap": {"value": 4, "mean": 3.987864077669903, "std": 1.1479607503907707, "bin": {}}, "setsize": {"value": 5, "mean": 4.609223300970874, "std": 0.650027914740976, "bin": {}}, "score": {"value": -2.573215637065198, "mean": -1.826379983323013, "std": 1.4166518955195957, "bin": {}}, "pval": {"value": 0.0100758408125454, "mean": 0.0933877027683096, "std": 0.1964804676103012, "bin": {}}, "signature_idxs": {"edge": [3169, 3160, 3083, 3190], "full": [3083, 3160, 3190, 2304, 3169]}}, "Phosphatase inhibitor activity": {"direction": "dw", "overlap": {"value": 3, "mean": 1.883495145631068, "std": 1.376297064299614, "bin": {}}, "setsize": {"value": 5, "mean": 6.12621359223301, "std": 1.190003766417189, "bin": {}}, "score": {"value": -2.3749203662625766, "mean": 0.0573377814368714, "std": 0.921571056188273, "bin": {}}, "pval": {"value": 0.0175527366401446, "mean": 0.5200857546723113, "std": 0.2842769695893924, "bin": {}}, "signature_idxs": {"edge": [3211, 3042, 3207], "full": [3211, 3207, 3042, 2141, 1030]}}, "Stat family protein binding": {"direction": "up", "overlap": {"value": 0, "mean": 0.6560509554140127, "std": 0.6047937564570304, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.3694267515923566, "std": 0.5675584563043431, "bin": {"bin_50": 7, "bin_100": 7, "bin_250": 7, "bin_500": 7}}, "score": {"value": 2.302400479066635, "mean": 0.1893382270508441, "std": 1.7766456883761927, "bin": {"bin_50": 35.9645390070922, "bin_100": 17.34020618556701, "bin_250": 6.708502024291498, "bin_500": 3.250167672702884}}, "pval": {"value": 0.0213125979876438, "mean": 0.3213499352899298, "std": 0.3107441830244326, "bin": {"bin_50": 0.0325017468768143, "bin_100": 0.0653907127050202, "bin_250": 0.1583736196074974, "bin_500": 0.295760276625992}}, "signature_idxs": {"edge": [], "full": [8]}}, "Protein phosphatase 2b binding": {"direction": "up", "overlap": {"value": 0, "mean": 0.35, "std": 0.5047501632220908, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0272727272727271, "std": 0.1628770260651719, "bin": {"bin_50": 6, "bin_100": 6, "bin_250": 6, "bin_500": 6}}, "score": {"value": 2.289789608201437, "mean": 0.7904185042497328, "std": 2.0127621987705138, "bin": {"bin_50": 43.16170212765957, "bin_100": 20.81030927835052, "bin_250": 8.051012145748988, "bin_500": 3.900603621730382}}, "pval": {"value": 0.0220335158570246, "mean": 0.1851654550015946, "std": 0.2359104801542577, "bin": {"bin_50": 0.0279227766388577, "bin_100": 0.0563150378970086, "bin_250": 0.1373795195898598, "bin_500": 0.2595746201812825}}, "signature_idxs": {"edge": [], "full": [16]}}, "Phosphoserine residue binding": {"direction": "dw", "overlap": {"value": 3, "mean": 2.0024271844660193, "std": 1.3191987609573812, "bin": {}}, "setsize": {"value": 6, "mean": 4.730582524271845, "std": 1.227807522028966, "bin": {}}, "score": {"value": -2.2875762325353257, "mean": -0.0950951095116307, "std": 0.8430708127846518, "bin": {}}, "pval": {"value": 0.0221622113169208, "mean": 0.570849259517103, "std": 0.2925412018461248, "bin": {}}, "signature_idxs": {"edge": [2994, 3155, 3001], "full": [3155, 1586, 2994, 713, 3001, 1863]}}, "Protein serine threonine phosphatase inhibitor activity": {"direction": "dw", "overlap": {"value": 1, "mean": 0.4344569288389513, "std": 0.5178571385383591, "bin": {}}, "setsize": {"value": 1, "mean": 1.0636704119850189, "std": 0.2441648840899868, "bin": {}}, "score": {"value": -2.28540529449358, "mean": 0.3005752109319936, "std": 1.971323516703387, "bin": {}}, "pval": {"value": 0.0222890738523751, "mean": 0.24635576282705, "std": 0.2812303798593795, "bin": {}}, "signature_idxs": {"edge": [3207], "full": [3207]}}, "Activin binding": {"direction": "up", 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"mean": 0.8174935736497821, "std": 1.2372108727630755, "bin": {}}, "pval": {"value": 0.0473561910623812, "mean": 0.2734948556707107, "std": 0.2654117957889352, "bin": {}}, "signature_idxs": {"edge": [2606, 2956, 2692, 2612], "full": [2692, 2606, 1539, 2612, 2956, 1992]}}, "Deoxyribonuclease i activity": {"direction": "up", "overlap": {"value": 0, "mean": 0.5088757396449705, "std": 0.4999212150386845, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 2, "bin_100": 2, "bin_250": 2, "bin_500": 2}}, "score": {"value": 1.9814098635734396, "mean": -0.1350973878263665, "std": 1.8321292196678003, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 40.27125506072875, "bin_500": 19.51106639839034}}, "pval": {"value": 0.0475453285180162, "mean": 0.2916211202000204, "std": 0.3028889022651563, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0480572346493884, "bin_500": 0.095304315936589}}, "signature_idxs": {"edge": 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