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b8dc22f verified
term overlap setsize score pval
Metabolism of lipids 16 508 3.718157181571816 3.149686494044042e-05
Protein localization 8 142 6.464633354964309 7.348969636463593e-05
The citric acid tca cycle and respiratory electron transport 8 160 5.688787185354691 0.0001690733465498
Fatty acid metabolism 6 117 5.741805635422657 0.000995774897974
Insertion of tail anchored proteins into the endoplasmic reticulum membrane 3 19 19.484536082474225 0.0007914120786236
Transport of small molecules 11 377 3.28574937066372 0.0011289483032464
Heme degradation 2 7 41.18775510204082 0.0019368511639724
Complex i biogenesis 4 56 8.048076923076923 0.0021648846033271
Mitochondrial protein import 4 59 7.606818181818181 0.0026232179628348
Srp dependent cotranslational protein targeting to membrane 5 108 5.106285130301482 0.0041233790686571
Iron uptake and transport 3 38 8.890427098674522 0.0060217503205503
Carnitine metabolism 2 12 20.583673469387755 0.0058956460302812
Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 5 116 4.734471313418682 0.0055802593941936
Phase i functionalization of compounds 3 39 8.642611683848797 0.006477682080963
Ion channel transport 4 82 5.351495726495727 0.0084964197325681
Mitochondrial biogenesis 4 85 5.151748971193416 0.0096196388866906
Metabolism of porphyrins 2 17 13.7156462585034 0.0117676307173903
Ikk complex recruitment mediated by rip1 2 16 14.696793002915452 0.0104494791604543
Pink1 prkn mediated mitophagy 2 17 13.7156462585034 0.0117676307173903
Pyruvate metabolism and citric acid tca cycle 3 48 6.907903780068729 0.0115064399741943
Cdt1 association with the cdc6 orc origin complex 1 54 1.9140461215932916 0.4135270958140081
Dna replication pre initiation 1 92 1.1105561105561106 0.5978216913417371
Negative regulation of met activity 0 20 0.0 1.0
Met receptor activation 0 4 0.0 1.0
Switching of origins to a post replicative state 1 85 1.203944203944204 0.5688343041108967
Signaling by met 0 64 0.0 1.0
Metabolism of fat soluble vitamins 0 29 0.0 1.0
Keratinization 0 24 0.0 1.0
Activation of the pre replicative complex 0 33 0.0 1.0
Regulation of tp53 activity through methylation 0 16 0.0 1.0
Polymerase switching 0 16 0.0 1.0
Regulation of tp53 activity through association with co factors 0 12 0.0 1.0
Processive synthesis on the lagging strand 0 17 0.0 1.0
Regulation of tp53 activity through acetylation 0 30 0.0 1.0
Regulation of tp53 expression and degradation 0 33 0.0 1.0
Dna replication initiation 0 8 0.0 1.0
Pten regulation 2 128 1.614836410754778 0.358299876386484
Rna polymerase ii transcribes snrna genes 0 73 0.0 1.0
Cdc6 association with the orc origin complex 0 12 0.0 1.0
Mitotic prometaphase 3 198 1.5703409992069786 0.3073420480660703
Assembly of the orc complex at the origin of replication 0 20 0.0 1.0
Glycerophospholipid catabolism 0 4 0.0 1.0
Cooperation of pdcl phlp1 and tric cct in g protein beta folding 0 27 0.0 1.0
Pi5p regulates tp53 acetylation 0 9 0.0 1.0
Intra golgi and retrograde golgi to er traffic 2 181 1.1306578497320716 0.5329680993593728
Retrograde transport at the trans golgi network 0 49 0.0 1.0
Intra golgi traffic 0 42 0.0 1.0
Mitotic telophase cytokinesis 0 13 0.0 1.0
Copi independent golgi to er retrograde traffic 1 45 2.307621671258035 0.3588505448912167
Regulation of tp53 activity through phosphorylation 1 82 1.248908841501434 0.5557866832475982
M phase 4 355 1.1568138651471984 0.4617529252712169
Formation of the cornified envelope 0 24 0.0 1.0
G2 phase 0 4 0.0 1.0
Copi mediated anterograde transport 2 89 2.347877081867229 0.2171594264364444
Orc1 removal from chromatin 1 65 1.5833333333333333 0.4741193373633443
Mitotic prophase 1 93 1.098375054896794 0.6018020784024207
Copi dependent golgi to er retrograde traffic 1 83 1.2335550628233556 0.5601787468810149
Fgfr2 alternative splicing 0 26 0.0 1.0
Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 0 16 0.0 1.0
Interleukin 10 signaling 0 6 0.0 1.0
Interleukin 6 family signaling 0 10 0.0 1.0
Fanconi anemia pathway 1 36 2.903607503607504 0.299132167535026
Synthesis of wybutosine at g37 of trna phe 0 6 0.0 1.0
Trna modification in the nucleus and cytosol 0 43 0.0 1.0
Dual incision in tc ner 0 67 0.0 1.0
Transcription coupled nucleotide excision repair tc ner 0 82 0.0 1.0
Formation of tc ner pre incision complex 0 53 0.0 1.0
Highly calcium permeable nicotinic acetylcholine receptors 0 2 0.0 1.0
Trna processing in the nucleus 1 60 1.7183701420989557 0.4473868461248688
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 0 2 0.0 1.0
Presynaptic nicotinic acetylcholine receptors 0 2 0.0 1.0
Inflammasomes 1 12 9.26078971533517 0.1116045715736199
Respiratory electron transport 4 101 4.295103092783505 0.0172354677097154
Deposition of new cenpa containing nucleosomes at the centromere 1 34 3.0801958983777165 0.2851312580635185
Post translational protein modification 12 1003 1.252866709476195 0.2771441510179642
Dual incision in gg ner 0 42 0.0 1.0
Global genome nucleotide excision repair gg ner 0 87 0.0 1.0
Nucleotide excision repair 0 114 0.0 1.0
Gap filling dna repair synthesis and ligation in gg ner 0 28 0.0 1.0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors 0 1 0.0 1.0
Trna processing in the mitochondrion 0 5 0.0 1.0
Erbb2 regulates cell motility 0 6 0.0 1.0
Interleukin 4 and interleukin 13 signaling 1 40 2.6047656047656047 0.3263246311566628
Tp53 regulates transcription of genes involved in g2 cell cycle arrest 0 18 0.0 1.0
Tp53 regulates transcription of death receptors and ligands 0 10 0.0 1.0
Tp53 regulates transcription of caspase activators and caspases 0 8 0.0 1.0
Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain 0 11 0.0 1.0
Tp53 regulates transcription of genes involved in cytochrome c release 0 16 0.0 1.0
Antimicrobial peptides 0 7 0.0 1.0
Oncogenic mapk signaling 0 66 0.0 1.0
Ras signaling downstream of nf1 loss of function variants 0 5 0.0 1.0
Signaling by braf and raf1 fusions 0 53 0.0 1.0
Signaling by moderate kinase activity braf mutants 0 36 0.0 1.0
Neutrophil degranulation 4 319 1.2937830687830687 0.3821215451684728
Choline catabolism 0 4 0.0 1.0
Tp53 regulates transcription of dna repair genes 0 61 0.0 1.0
Protein protein interactions at synapses 0 46 0.0 1.0
Neurexins and neuroligins 0 28 0.0 1.0
Rrna modification in the mitochondrion 0 6 0.0 1.0
Tp53 regulates transcription of cell cycle genes 0 43 0.0 1.0
Rrna modification in the nucleus and cytosol 0 63 0.0 1.0
Il 6 type cytokine receptor ligand interactions 0 6 0.0 1.0
Gdp fucose biosynthesis 0 6 0.0 1.0
Trna modification in the mitochondrion 0 9 0.0 1.0
Tp53 regulates transcription of genes involved in g1 cell cycle arrest 0 13 0.0 1.0
Lagging strand synthesis 0 23 0.0 1.0
Cyclin d associated events in g1 0 45 0.0 1.0
G1 s specific transcription 0 29 0.0 1.0
Irs activation 0 4 0.0 1.0
Purine catabolism 0 14 0.0 1.0
Purine salvage 0 12 0.0 1.0
Ketone body metabolism 1 7 16.986531986531986 0.0666860823201616
Rna polymerase iii transcription 0 44 0.0 1.0
Rna polymerase iii transcription termination 0 24 0.0 1.0
Dna damage reversal 0 8 0.0 1.0
Resolution of abasic sites ap sites 0 41 0.0 1.0
Base excision repair ap site formation 0 23 0.0 1.0
Signal attenuation 0 9 0.0 1.0
Dna repair 2 291 0.6925358378645576 0.7838504087115428
Death receptor signalling 1 120 0.8468720821661998 0.6956974355499302
Chromosome maintenance 1 100 1.0199979593918989 0.6285936102034135
Base excision repair 0 55 0.0 1.0
Rna polymerase i transcription 0 63 0.0 1.0
Rna polymerase i transcription termination 0 32 0.0 1.0
Rna polymerase ii transcription 5 969 0.4985804760864817 0.9669975066471672
Rna polymerase ii transcription termination 0 66 0.0 1.0
Purine ribonucleoside monophosphate biosynthesis 0 11 0.0 1.0
Rna polymerase iii chain elongation 0 19 0.0 1.0
Dna damage bypass 1 49 2.114478114478114 0.3837477700803094
Insulin receptor signalling cascade 0 31 0.0 1.0
Signaling by insulin receptor 1 45 2.307621671258035 0.3588505448912167
Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 0 14 0.0 1.0
Beta oxidation of lauroyl coa to decanoyl coa coa 0 4 0.0 1.0
Mitochondrial fatty acid beta oxidation 1 33 3.176767676767677 0.2780273254227372
Mitochondrial fatty acid beta oxidation of unsaturated fatty acids 1 5 25.484848484848484 0.0480955538847994
Mitochondrial fatty acid beta oxidation of saturated fatty acids 0 9 0.0 1.0
Synthesis of ketone bodies 0 6 0.0 1.0
Rna polymerase iii transcription initiation from type 3 promoter 0 30 0.0 1.0
Rna polymerase iii transcription initiation from type 1 promoter 0 31 0.0 1.0
Platelet aggregation plug formation 0 20 0.0 1.0
Response to elevated platelet cytosolic ca2 1 71 1.446753246753247 0.5045129832066302
Platelet activation signaling and aggregation 1 152 0.6652618904274533 0.7789574534058219
Tnf signaling 1 39 2.6735778841042 0.3196260593385788
Platelet adhesion to exposed collagen 0 7 0.0 1.0
Synthesis of very long chain fatty acyl coas 1 17 6.363636363636363 0.1543818096433915
Dissolution of fibrin clot 0 7 0.0 1.0
Trail signaling 0 6 0.0 1.0
Fasl cd95l signaling 0 5 0.0 1.0
Apoptotic execution phase 0 47 0.0 1.0
Triglyceride biosynthesis 0 7 0.0 1.0
Fatty acyl coa biosynthesis 1 29 3.632034632034632 0.2489059409173845
Mrna editing 0 4 0.0 1.0
Processing of capped intronless pre mrna 0 29 0.0 1.0
Rna polymerase i promoter escape 0 42 0.0 1.0
Rna polymerase i transcription initiation 0 49 0.0 1.0
Pyrimidine catabolism 0 6 0.0 1.0
Pyrimidine salvage 0 9 0.0 1.0
Galactose catabolism 0 5 0.0 1.0
Fructose catabolism 0 3 0.0 1.0
Glucose metabolism 1 80 1.28078250863061 0.5468718822386345
Pyruvate metabolism 1 26 4.069090909090909 0.2263045436956677
Gluconeogenesis 0 25 0.0 1.0
Glycogen breakdown glycogenolysis 0 13 0.0 1.0
Glycolysis 1 66 1.5588189588189587 0.4793101444108065
Cyclin a cdk2 associated events at s phase entry 1 79 1.2973322973322974 0.5423482911753763
Cell cycle checkpoints 5 257 2.0559732664995822 0.1080209369470052
Mitotic spindle checkpoint 3 111 2.860252004581901 0.095403296278499
G1 s dna damage checkpoints 1 61 1.6895622895622897 0.4528388306838392
Stabilization of p53 1 51 2.029494949494949 0.3958350013250431
G2 m checkpoints 2 134 1.5405071119356837 0.3794730020368597
G2 m dna replication checkpoint 0 5 0.0 1.0
G2 m dna damage checkpoint 1 66 1.5588189588189587 0.4793101444108065
Dna replication 1 137 0.7397504456327986 0.743192575047898
Cell cycle mitotic 4 498 0.809885290148448 0.7266252704800125
Cyclin a b1 b2 associated events during g2 m transition 0 24 0.0 1.0
S phase 1 158 0.6394518432734994 0.7918406993472096
Synthesis of dna 1 117 0.869035179380007 0.6864562302095232
Formation of incision complex in gg ner 0 42 0.0 1.0
Urea cycle 0 6 0.0 1.0
Dna strand elongation 0 35 0.0 1.0
Branched chain amino acid catabolism 0 22 0.0 1.0
Propionyl coa catabolism 0 5 0.0 1.0
Transport of nucleotide sugars 0 4 0.0 1.0
Translation 5 289 1.8183839881393624 0.1541180378169463
Recycling of eif2 gdp 0 8 0.0 1.0
Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s 1 59 1.748171368861024 0.4418810858922499
Eukaryotic translation initiation 3 116 2.732323693093696 0.1053672202985524
Rrna processing 4 202 2.082912457912458 0.1367399977272872
Trna processing 1 109 0.934156378600823 0.6604325757838254
Processing of capped intron containing pre mrna 4 239 1.748404255319149 0.207348157536694
Transport of mature transcript to cytoplasm 1 81 1.2646464646464646 0.5513512032975088
Mrna editing c to u conversion 0 2 0.0 1.0
Mrna splicing 3 188 1.656896071329061 0.2805131699769362
Mrna splicing minor pathway 1 52 1.989502871855813 0.4017902994798545
Mrna capping 0 29 0.0 1.0
Citric acid cycle tca cycle 2 21 10.823845327604726 0.0177148463510605
Metabolism of carbohydrates 1 201 0.4997979797979798 0.8647837066853694
Ethanol oxidation 1 5 25.484848484848484 0.0480955538847994
Pentose phosphate pathway 0 13 0.0 1.0
Metabolism of amino acids and derivatives 5 281 1.8726163234172388 0.1418938445724651
Creatine metabolism 0 6 0.0 1.0
Tryptophan catabolism 0 6 0.0 1.0
Lysine catabolism 0 11 0.0 1.0
Histidine catabolism 0 3 0.0 1.0
Dna damage recognition in gg ner 0 37 0.0 1.0
Resolution of d loop structures through synthesis dependent strand annealing sdsa 1 26 4.069090909090909 0.2263045436956677
Processing of dna double strand break ends 1 66 1.5588189588189587 0.4793101444108065
Piwi interacting rna pirna biogenesis 0 16 0.0 1.0
Metabolic disorders of biological oxidation enzymes 0 13 0.0 1.0
Ion homeostasis 1 31 3.3892255892255894 0.2636091346473535
Physiological factors 0 6 0.0 1.0
Transcriptional regulation by small rnas 1 57 1.810966810966811 0.4307061333231872
Phase 2 plateau phase 0 3 0.0 1.0
Phase 0 rapid depolarisation 0 6 0.0 1.0
Cardiac conduction 1 43 2.417989417989418 0.3460310778663031
Phase 3 rapid repolarisation 0 1 0.0 1.0
Ikba variant leads to eda id 0 7 0.0 1.0
Phase 4 resting membrane potential 0 2 0.0 1.0
Organic cation transport 0 3 0.0 1.0
Aflatoxin activation and detoxification 0 6 0.0 1.0
Diseases of mismatch repair mmr 0 5 0.0 1.0
Negative regulation of tcf dependent signaling by dvl interacting proteins 0 5 0.0 1.0
Mitochondrial translation 0 93 0.0 1.0
Ra biosynthesis pathway 0 9 0.0 1.0
Release of hh np from the secreting cell 0 2 0.0 1.0
Signaling by retinoic acid 0 26 0.0 1.0
Mismatch repair 1 17 6.363636363636363 0.1543818096433915
Organic cation anion zwitterion transport 0 3 0.0 1.0
Synthesis of diphthamide eef2 0 8 0.0 1.0
Irak4 deficiency tlr2 4 0 4 0.0 1.0
Clec7a dectin 1 induces nfat activation 0 10 0.0 1.0
Rho gtpases activate pkns 0 40 0.0 1.0
Trafficking of myristoylated proteins to the cilium 0 4 0.0 1.0
Cd209 dc sign signaling 0 18 0.0 1.0
C type lectin receptors clrs 1 100 1.0199979593918989 0.6285936102034135
Dectin 2 family 0 4 0.0 1.0
Pyroptosis 0 16 0.0 1.0
Intraflagellar transport 1 48 2.1596819256393727 0.3776146865857887
Bbsome mediated cargo targeting to cilium 0 18 0.0 1.0
Cargo trafficking to the periciliary membrane 0 43 0.0 1.0
Dectin 1 mediated noncanonical nf kb signaling 1 53 1.951048951048951 0.4076874771235006
Vxpx cargo targeting to cilium 0 18 0.0 1.0
Disorders of transmembrane transporters 2 115 1.8029618927216904 0.3116411944565507
Slc transporter disorders 1 54 1.9140461215932916 0.4135270958140081
Abc transporter disorders 1 61 1.6895622895622897 0.4528388306838392
Cilium assembly 1 183 0.5502275502275502 0.837983208313382
Activation of anterior hox genes in hindbrain development during early embryogenesis 1 60 1.7183701420989557 0.4473868461248688
Hedgehog off state 1 96 1.063370547581074 0.6135107249346667
Degradation of gli1 by the proteasome 1 53 1.951048951048951 0.4076874771235006
Diseases associated with glycosylation precursor biosynthesis 0 16 0.0 1.0
Clec7a dectin 1 signaling 1 85 1.203944203944204 0.5688343041108967
Anchoring of the basal body to the plasma membrane 0 95 0.0 1.0
Signaling by hedgehog 1 122 0.8327072376659154 0.7017079055797242
Hedgehog ligand biogenesis 1 53 1.951048951048951 0.4076874771235006
Tnfr1 induced nfkappab signaling pathway 1 28 3.7669285447063214 0.2414457297612108
Wnt5a dependent internalization of fzd2 fzd5 and ror2 0 12 0.0 1.0
Interleukin 3 interleukin 5 and gm csf signaling 0 31 0.0 1.0
Wnt5a dependent internalization of fzd4 0 13 0.0 1.0
Defective c1galt1c1 causes tnps 0 2 0.0 1.0
Defective lfng causes scdo3 0 3 0.0 1.0
Defective galnt3 causes hftc 0 1 0.0 1.0
Gpcr ligand binding 1 46 2.2561167227833896 0.3651666660190783
Presynaptic function of kainate receptors 0 13 0.0 1.0
Interconversion of nucleotide di and triphosphates 0 26 0.0 1.0
O linked glycosylation 0 35 0.0 1.0
Signaling by ctnnb1 phospho site mutants 0 15 0.0 1.0
Sumoylation of immune response proteins 0 10 0.0 1.0
Sumoylation of dna methylation proteins 0 16 0.0 1.0
Repression of wnt target genes 0 13 0.0 1.0
Regulation of fzd by ubiquitination 0 9 0.0 1.0
Disassembly of the destruction complex and recruitment of axin to the membrane 0 24 0.0 1.0
Degradation of dvl 1 50 2.0711193568336426 0.3898210156705143
Degradation of axin 1 48 2.1596819256393727 0.3776146865857887
Sumoylation of dna replication proteins 1 46 2.2561167227833896 0.3651666660190783
Asymmetric localization of pcp proteins 1 54 1.9140461215932916 0.4135270958140081
Signaling by wnt in cancer 0 25 0.0 1.0
O glycosylation of tsr domain containing proteins 0 5 0.0 1.0
Mitophagy 2 24 9.34508348794063 0.0228441699597423
Uptake and function of anthrax toxins 0 10 0.0 1.0
Regulation of tnfr1 signaling 1 31 3.3892255892255894 0.2636091346473535
Programmed cell death 3 179 1.7432052483598874 0.2565819819765139
Tnfr1 induced proapoptotic signaling 1 13 8.488215488215488 0.1203280145079081
Caspase activation via extrinsic apoptotic signalling pathway 1 18 5.98871063576946 0.1626892876910785
Signaling by rnf43 mutants 0 4 0.0 1.0
Signaling by lrp5 mutants 0 2 0.0 1.0
Uptake and actions of bacterial toxins 0 23 0.0 1.0
Uptake and function of diphtheria toxin 0 5 0.0 1.0
Dna methylation 0 14 0.0 1.0
N glycan trimming in the er and calnexin calreticulin cycle 0 32 0.0 1.0
Diseases of immune system 0 15 0.0 1.0
Myogenesis 0 22 0.0 1.0
Toxicity of botulinum toxin type d botd 0 3 0.0 1.0
Negative epigenetic regulation of rrna expression 0 61 0.0 1.0
B wich complex positively regulates rrna expression 0 45 0.0 1.0
Positive epigenetic regulation of rrna expression 0 60 0.0 1.0
Miscellaneous transport and binding events 0 17 0.0 1.0
Vegfr2 mediated cell proliferation 0 15 0.0 1.0
Vegfr2 mediated vascular permeability 0 22 0.0 1.0
Regulated necrosis 1 42 2.477211135747721 0.339526513295544
Ripk1 mediated regulated necrosis 1 26 4.069090909090909 0.2263045436956677
Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3 0 14 0.0 1.0
Rho gtpases activate cit 0 18 0.0 1.0
Rho gtpases activate ktn1 0 11 0.0 1.0
Rho gtpases activate iqgaps 0 26 0.0 1.0
Defective cftr causes cystic fibrosis 1 54 1.9140461215932916 0.4135270958140081
Protein repair 0 5 0.0 1.0
Tnf receptor superfamily tnfsf members mediating non canonical nf kb pathway 0 5 0.0 1.0
Negative regulation of mapk pathway 0 36 0.0 1.0
Negative feedback regulation of mapk pathway 0 6 0.0 1.0
Constitutive signaling by akt1 e17k in cancer 0 25 0.0 1.0
Map2k and mapk activation 0 31 0.0 1.0
Raf activation 0 33 0.0 1.0
Tnfs bind their physiological receptors 0 1 0.0 1.0
Lgi adam interactions 0 5 0.0 1.0
Diseases of metabolism 1 131 0.7743589743589744 0.7273327797177289
Tnfr2 non canonical nf kb pathway 1 58 1.7790182527024632 0.4363210249842685
Rho gtpases activate rhotekin and rhophilins 0 8 0.0 1.0
Rho gtpases activate formins 3 133 2.370975416336241 0.1420367484612055
Rho gtpases activate wasps and waves 1 33 3.176767676767677 0.2780273254227372
Infectious disease 10 619 1.7308885239919722 0.0813380268353445
Diseases of signal transduction by growth factor receptors and second messengers 1 333 0.2970670561032006 0.9644569591737788
Diseases of carbohydrate metabolism 0 23 0.0 1.0
Formation of xylulose 5 phosphate 0 5 0.0 1.0
Metallothioneins bind metals 0 2 0.0 1.0
Rho gtpases activate nadph oxidases 0 13 0.0 1.0
Mapk family signaling cascades 3 212 1.4630789720317663 0.3450558105562775
Surfactant metabolism 0 8 0.0 1.0
Map3k8 tpl2 dependent mapk1 3 activation 0 14 0.0 1.0
Dna double strand break response 0 49 0.0 1.0
Homologous dna pairing and strand exchange 1 41 2.5393939393939395 0.3329579057594876
Nonhomologous end joining nhej 0 41 0.0 1.0
Beta oxidation of decanoyl coa to octanoyl coa coa 0 6 0.0 1.0
Sensing of dna double strand breaks 0 6 0.0 1.0
Homology directed repair 1 106 0.9611351611351612 0.6501318995178187
Resolution of d loop structures 1 32 3.2795698924731185 0.27085351108605
Dna double strand break repair 1 137 0.7397504456327986 0.743192575047898
Cd22 mediated bcr regulation 0 2 0.0 1.0
Metalloprotease dubs 0 20 0.0 1.0
Ovarian tumor domain proteases 1 34 3.0801958983777165 0.2851312580635185
Ub specific processing proteases 4 151 2.820011337868481 0.0609578144277862
Josephin domain dubs 0 9 0.0 1.0
Uch proteinases 2 79 2.6554465942221044 0.181453052630302
Deubiquitination 5 221 2.4074074074074074 0.065964466588521
Diseases associated with surfactant metabolism 0 1 0.0 1.0
Mapk6 mapk4 signaling 1 77 1.331738437001595 0.5331665625078387
Regulation of tlr by endogenous ligand 0 3 0.0 1.0
Hdr through homologous recombination hrr 1 66 1.5588189588189587 0.4793101444108065
Hdr through mmej alt nhej 0 11 0.0 1.0
Hdr through single strand annealing ssa 1 35 2.989304812834225 0.2921659829416722
Clec7a inflammasome pathway 0 4 0.0 1.0
Cargo concentration in the er 0 23 0.0 1.0
Response to metal ions 0 5 0.0 1.0
Regulation of ras by gaps 1 57 1.810966810966811 0.4307061333231872
Pi 3k cascade fgfr1 0 8 0.0 1.0
Shc mediated cascade fgfr1 0 8 0.0 1.0
Downstream signaling of activated fgfr1 0 15 0.0 1.0
Phospholipase c mediated cascade fgfr4 0 3 0.0 1.0
Phospholipase c mediated cascade fgfr2 0 3 0.0 1.0
Vesicle mediated transport 4 546 0.7344710947109471 0.7905096711741383
Fructose metabolism 0 5 0.0 1.0
Pcna dependent long patch base excision repair 0 24 0.0 1.0
Apex1 independent resolution of ap sites via the single nucleotide replacement pathway 0 7 0.0 1.0
Frs mediated fgfr1 signaling 0 9 0.0 1.0
Constitutive signaling by egfrviii 0 14 0.0 1.0
Activation of smo 0 11 0.0 1.0
Tp53 regulates transcription of cell death genes 0 34 0.0 1.0
Regulation of tp53 activity 1 146 0.6932079414838036 0.7652853062466158
Hedgehog on state 1 70 1.4678670765627286 0.4995709622922107
Ligand receptor interactions 0 2 0.0 1.0
Tp53 regulates metabolic genes 0 84 0.0 1.0
Rho gtpases activate paks 0 19 0.0 1.0
Rho gtpases activate rocks 0 19 0.0 1.0
Tnfr1 mediated ceramide production 0 3 0.0 1.0
Gli proteins bind promoters of hh responsive genes to promote transcription 0 2 0.0 1.0
Pi 3k cascade fgfr2 0 8 0.0 1.0
Downstream signaling of activated fgfr2 0 14 0.0 1.0
Frs mediated fgfr2 signaling 0 9 0.0 1.0
Termination of translesion dna synthesis 0 34 0.0 1.0
Translesion synthesis by polk 0 17 0.0 1.0
Signaling by fgfr1 in disease 0 29 0.0 1.0
Signaling by fgfr4 in disease 0 11 0.0 1.0
Signaling by fgfr2 in disease 0 28 0.0 1.0
Signaling by fgfr4 0 26 0.0 1.0
Signaling by fgfr3 0 27 0.0 1.0
Signaling by fgfr2 0 51 0.0 1.0
Signaling by fgfr1 0 28 0.0 1.0
Negative regulation of fgfr4 signaling 0 17 0.0 1.0
Negative regulation of fgfr3 signaling 0 17 0.0 1.0
Negative regulation of fgfr2 signaling 0 17 0.0 1.0
Negative regulation of fgfr1 signaling 0 17 0.0 1.0
Pi 3k cascade fgfr4 0 8 0.0 1.0
Shc mediated cascade fgfr4 0 8 0.0 1.0
Downstream signaling of activated fgfr4 0 14 0.0 1.0
Frs mediated fgfr4 signaling 0 9 0.0 1.0
Pi 3k cascade fgfr3 0 8 0.0 1.0
Downstream signaling of activated fgfr3 0 14 0.0 1.0
Frs mediated fgfr3 signaling 0 9 0.0 1.0
Shc mediated cascade fgfr3 0 8 0.0 1.0
Fgfrl1 modulation of fgfr1 signaling 0 2 0.0 1.0
Beta oxidation of octanoyl coa to hexanoyl coa 0 5 0.0 1.0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0 8 0.0 1.0
Beta oxidation of butanoyl coa to acetyl coa 0 5 0.0 1.0
Foxo mediated transcription of oxidative stress metabolic and neuronal genes 0 18 0.0 1.0
Foxo mediated transcription of cell death genes 0 12 0.0 1.0
Regulation of localization of foxo transcription factors 0 13 0.0 1.0
Foxo mediated transcription 0 47 0.0 1.0
Chaperone mediated autophagy 0 16 0.0 1.0
Lipophagy 0 8 0.0 1.0
Autophagy 3 130 2.4277132884162675 0.1352776549759777
Hcmv late events 1 62 1.661698956780924 0.4582375595260778
Assembly and cell surface presentation of nmda receptors 0 28 0.0 1.0
Late endosomal microautophagy 0 29 0.0 1.0
Hcmv early events 3 79 4.077590884427564 0.0423756480977277
Flt3 signaling 0 27 0.0 1.0
Diseases of base excision repair 0 4 0.0 1.0
Negative regulation of notch4 signaling 1 49 2.114478114478114 0.3837477700803094
Class i peroxisomal membrane protein import 1 19 5.6554433221099885 0.1709159600444602
Activated ntrk3 signals through pi3k 0 4 0.0 1.0
Transport to the golgi and subsequent modification 3 148 2.122502666192677 0.1774035227613552
Molybdenum cofactor biosynthesis 0 7 0.0 1.0
Traf6 mediated induction of tak1 complex within tlr4 complex 1 11 10.187878787878788 0.1027954944442906
Irak2 mediated activation of tak1 complex 0 9 0.0 1.0
Hcmv infection 3 102 3.1230865354576696 0.0785306043043279
Irak1 recruits ikk complex 0 12 0.0 1.0
Postmitotic nuclear pore complex npc reformation 1 27 3.912198912198912 0.2339121686337894
Negative regulation of nmda receptor mediated neuronal transmission 0 14 0.0 1.0
Amino acids regulate mtorc1 1 45 2.307621671258035 0.3588505448912167
Response of mtb to phagocytosis 0 20 0.0 1.0
Suppression of phagosomal maturation 0 11 0.0 1.0
Modulation by mtb of host immune system 0 4 0.0 1.0
Prevention of phagosomal lysosomal fusion 0 8 0.0 1.0
Infection with mycobacterium tuberculosis 0 21 0.0 1.0
Suppression of apoptosis 0 6 0.0 1.0
Estrogen dependent nuclear events downstream of esr membrane signaling 0 15 0.0 1.0
Estrogen stimulated signaling through prkcz 0 6 0.0 1.0
Transcriptional regulation of granulopoiesis 0 34 0.0 1.0
Regulation of glycolysis by fructose 2 6 bisphosphate metabolism 0 11 0.0 1.0
Response of eif2ak4 gcn2 to amino acid deficiency 3 94 3.400362524073864 0.0647665856554279
Nr1h2 nr1h3 regulate gene expression linked to gluconeogenesis 0 4 0.0 1.0
Nr1h2 nr1h3 regulate gene expression to control bile acid homeostasis 0 6 0.0 1.0
Long term potentiation 0 11 0.0 1.0
Egr2 and sox10 mediated initiation of schwann cell myelination 0 20 0.0 1.0
Activation of ampk downstream of nmdars 0 21 0.0 1.0
Activation of rac1 downstream of nmdars 0 6 0.0 1.0
Foxo mediated transcription of cell cycle genes 0 13 0.0 1.0
Regulation of foxo transcriptional activity by acetylation 0 10 0.0 1.0
Constitutive signaling by overexpressed erbb2 0 11 0.0 1.0
Activation of irf3 irf7 mediated by tbk1 ikk epsilon 1 11 10.187878787878788 0.1027954944442906
Ion transport by p type atpases 2 31 7.0844475721323015 0.0368247433715485
Negative regulators of ddx58 ifih1 signaling 0 29 0.0 1.0
Nr1h2 nr1h3 regulate gene expression to limit cholesterol uptake 0 3 0.0 1.0
Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux 1 26 4.069090909090909 0.2263045436956677
Nr1h2 nr1h3 regulate gene expression linked to lipogenesis 0 7 0.0 1.0
Activated ntrk2 signals through frs2 and frs3 0 7 0.0 1.0
Activated ntrk2 signals through pi3k 0 4 0.0 1.0
Erythropoietin activates ras 0 11 0.0 1.0
Erythropoietin activates stat5 0 4 0.0 1.0
Erythropoietin activates phospholipase c gamma plcg 0 5 0.0 1.0
Erythropoietin activates phosphoinositide 3 kinase pi3k 0 8 0.0 1.0
Nr1h2 nr1h3 regulate gene expression linked to triglyceride lipolysis in adipose 0 3 0.0 1.0
Activated ntrk2 signals through ras 0 6 0.0 1.0
Mecp2 regulates transcription factors 0 4 0.0 1.0
Mecp2 regulates transcription of neuronal ligands 0 4 0.0 1.0
Mecp2 regulates neuronal receptors and channels 0 12 0.0 1.0
Regulation of mecp2 expression and activity 0 30 0.0 1.0
Loss of mecp2 binding ability to the ncor smrt complex 0 7 0.0 1.0
Interleukin 21 signaling 0 5 0.0 1.0
Interleukin 27 signaling 0 8 0.0 1.0
Interleukin 23 signaling 0 5 0.0 1.0
Interleukin 1 signaling 1 82 1.248908841501434 0.5557866832475982
Nr1h2 and nr1h3 mediated signaling 1 31 3.3892255892255894 0.2636091346473535
Ngf stimulated transcription 0 22 0.0 1.0
Activated ntrk2 signals through fyn 0 4 0.0 1.0
Ntrk2 activates rac1 0 3 0.0 1.0
Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10 1 13 8.488215488215488 0.1203280145079081
Traf6 mediated nf kb activation 0 22 0.0 1.0
Traf6 mediated irf7 activation 0 15 0.0 1.0
Nonsense mediated decay nmd 3 110 2.8872723769149244 0.0934596512163871
Traf3 dependent irf activation pathway 0 13 0.0 1.0
Transferrin endocytosis and recycling 1 18 5.98871063576946 0.1626892876910785
Endosomal sorting complex required for transport escrt 0 30 0.0 1.0
O linked glycosylation of mucins 0 22 0.0 1.0
Interferon signaling 1 128 0.7928895251729897 0.7190430615096002
Regulation of ifna signaling 0 8 0.0 1.0
Regulation of signaling by cbl 0 18 0.0 1.0
Interleukin receptor shc signaling 0 14 0.0 1.0
Meiotic recombination 0 31 0.0 1.0
Interferon alpha beta signaling 0 31 0.0 1.0
Rhof gtpase cycle 0 42 0.0 1.0
Activated ntrk3 signals through ras 0 6 0.0 1.0
Signaling by ntrk3 trkc 0 15 0.0 1.0
Blood group systems biosynthesis 0 5 0.0 1.0
Tysnd1 cleaves peroxisomal proteins 0 7 0.0 1.0
Peroxisomal protein import 0 51 0.0 1.0
Activated ntrk2 signals through cdk5 0 3 0.0 1.0
Stat5 activation 0 4 0.0 1.0
Interleukin 12 signaling 1 38 2.746109746109746 0.3128615540599918
Alpha protein kinase 1 signaling pathway 0 9 0.0 1.0
Aggrephagy 1 34 3.0801958983777165 0.2851312580635185
Regulation of bach1 activity 0 10 0.0 1.0
Heme signaling 1 36 2.903607503607504 0.299132167535026
Regulation of hmox1 expression and activity 2 58 3.6588921282798834 0.1106573079891401
Cytoprotection by hmox1 3 110 2.8872723769149244 0.0934596512163871
Rhobtb gtpase cycle 0 33 0.0 1.0
Flt3 signaling by cbl mutants 0 4 0.0 1.0
Flt3 signaling through src family kinases 0 2 0.0 1.0
Negative regulation of flt3 0 8 0.0 1.0
Rhobtb3 atpase cycle 0 9 0.0 1.0
Sensory perception 1 84 1.218571254715833 0.5645278149470376
Inactivation of csf3 g csf signaling 0 17 0.0 1.0
Signaling by flt3 fusion proteins 0 16 0.0 1.0
Stat5 activation downstream of flt3 itd mutants 0 6 0.0 1.0
Stat3 nuclear events downstream of alk signaling 0 6 0.0 1.0
Alk mutants bind tkis 0 12 0.0 1.0
Signaling by alk in cancer 0 52 0.0 1.0
Rnd1 gtpase cycle 0 36 0.0 1.0
Rnd2 gtpase cycle 0 40 0.0 1.0
Rnd3 gtpase cycle 0 39 0.0 1.0
Translation of sars cov 2 structural proteins 0 41 0.0 1.0
Signaling by flt3 itd and tkd mutants 0 12 0.0 1.0
Maturation of sars cov 2 nucleoprotein 0 13 0.0 1.0
Cellular response to starvation 4 139 3.074382716049383 0.0475904817832995
Miro gtpase cycle 0 8 0.0 1.0
Antigen activates b cell receptor bcr leading to generation of second messengers 0 20 0.0 1.0
Factors involved in megakaryocyte development and platelet production 0 117 0.0 1.0
Kinesins 0 47 0.0 1.0
Antigen presentation folding assembly and peptide loading of class i mhc 2 24 9.34508348794063 0.0228441699597423
Class i mhc mediated antigen processing presentation 6 295 2.166016343959361 0.0696786022050868
Antigen processing ubiquitination proteasome degradation 3 250 1.233231770942026 0.4458029496368113
Growth hormone receptor signaling 0 15 0.0 1.0
Gaba b receptor activation 0 16 0.0 1.0
Gaba receptor activation 0 18 0.0 1.0
Cellular response to chemical stress 3 133 2.370975416336241 0.1420367484612055
Serine biosynthesis 0 7 0.0 1.0
Termination of o glycan biosynthesis 0 4 0.0 1.0
Reactions specific to the complex n glycan synthesis pathway 0 6 0.0 1.0
N glycan antennae elongation 0 8 0.0 1.0
N glycan antennae elongation in the medial trans golgi 0 15 0.0 1.0
Traf6 mediated irf7 activation in tlr7 8 or 9 signaling 0 10 0.0 1.0
Defective intrinsic pathway for apoptosis 0 24 0.0 1.0
Nuclear events stimulated by alk signaling in cancer 0 17 0.0 1.0
Sensory perception of taste 0 4 0.0 1.0
Signaling by rho gtpases miro gtpases and rhobtb3 6 593 1.0339990575954183 0.5290177338622842
Amyloid fiber formation 0 41 0.0 1.0
Attachment and entry 0 4 0.0 1.0
Maturation of sars cov 2 spike protein 0 24 0.0 1.0
Sars cov 2 infection 0 62 0.0 1.0
Pexophagy 0 9 0.0 1.0
Killing mechanisms 0 9 0.0 1.0
Parasite infection 1 50 2.0711193568336426 0.3898210156705143
Fcgr3a mediated il10 synthesis 0 23 0.0 1.0
Selective autophagy 3 67 4.847938144329897 0.0279020879533615
Anti inflammatory response favouring leishmania parasite infection 0 46 0.0 1.0
Cd163 mediating an anti inflammatory response 0 5 0.0 1.0
Sensory processing of sound by outer hair cells of the cochlea 1 25 4.239057239057239 0.2186221342412543
Defective factor viii causes hemophilia a 0 3 0.0 1.0
Signaling by erbb2 ecd mutants 0 15 0.0 1.0
Purinergic signaling in leishmaniasis infection 1 12 9.26078971533517 0.1116045715736199
Signaling by mras complex mutants 0 8 0.0 1.0
Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects 0 17 0.0 1.0
Sensory processing of sound 1 40 2.6047656047656047 0.3263246311566628
Leishmania infection 2 110 1.8873771730914588 0.2934964278814309
Signaling by mapk mutants 0 4 0.0 1.0
Defects of contact activation system cas and kallikrein kinin system kks 0 5 0.0 1.0
Response of eif2ak1 hri to heme deficiency 0 10 0.0 1.0
Ras processing 1 19 5.6554433221099885 0.1709159600444602
N glycan trimming and elongation in the cis golgi 0 4 0.0 1.0
Adora2b mediated anti inflammatory cytokines production 0 30 0.0 1.0
Defective factor ix causes hemophilia b 0 3 0.0 1.0
Sealing of the nuclear envelope ne by escrt iii 0 26 0.0 1.0
Signaling by kit in disease 0 18 0.0 1.0
Defective ripk1 mediated regulated necrosis 1 6 20.385858585858585 0.0574361921538736
Transcriptional regulation of testis differentiation 0 4 0.0 1.0
Aberrant regulation of mitotic exit in cancer due to rb1 defects 0 20 0.0 1.0
Translation of sars cov 1 structural proteins 0 22 0.0 1.0
Maturation of sars cov 1 spike protein 0 5 0.0 1.0
Maturation of protein 3a 0 5 0.0 1.0
Maturation of sars cov 1 nucleoprotein 0 9 0.0 1.0
Flt3 signaling in disease 0 22 0.0 1.0
Sars cov infections 1 128 0.7928895251729897 0.7190430615096002
Translation of replicase and assembly of the replication transcription complex 0 13 0.0 1.0
Potential therapeutics for sars 1 68 1.5119855269109 0.4895400608205746
Sars cov 1 infection 0 42 0.0 1.0
Diseases of dna repair 1 33 3.176767676767677 0.2780273254227372
Diseases of mitotic cell cycle 0 38 0.0 1.0
Nervous system development 4 443 0.9165717539863326 0.6373196186268695
Signaling by csf3 g csf 0 22 0.0 1.0
Signaling by membrane tethered fusions of pdgfra or pdgfrb 0 3 0.0 1.0
Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants 0 11 0.0 1.0
Defective f9 activation 0 1 0.0 1.0
Signaling by pdgfr in disease 0 17 0.0 1.0
Inhibition of dna recombination at telomere 0 28 0.0 1.0
Diseases of programmed cell death 2 53 4.019607843137255 0.0951370618475993
Beta oxidation of hexanoyl coa to butanoyl coa 0 5 0.0 1.0
Interleukin 2 signaling 0 5 0.0 1.0
Biosynthesis of epa derived spms 0 3 0.0 1.0
Gaba synthesis release reuptake and degradation 0 12 0.0 1.0
Transcriptional regulation by runx1 1 149 0.678951678951679 0.7722229142029041
Transcriptional regulation by runx2 2 100 2.082049146189088 0.2570757650662602
Transcriptional regulation by runx3 1 86 1.1896613190730838 0.5730986271016891
Runx1 and foxp3 control the development of regulatory t lymphocytes tregs 0 3 0.0 1.0
Protein methylation 0 16 0.0 1.0
Inla mediated entry of listeria monocytogenes into host cells 0 9 0.0 1.0
Listeria monocytogenes entry into host cells 0 21 0.0 1.0
Rab gefs exchange gtp for gdp on rabs 0 79 0.0 1.0
Runx1 regulates estrogen receptor mediated transcription 0 5 0.0 1.0
Met promotes cell motility 0 29 0.0 1.0
Met activates rap1 and rac1 0 11 0.0 1.0
Met interacts with tns proteins 0 4 0.0 1.0
Inlb mediated entry of listeria monocytogenes into host cell 0 15 0.0 1.0
Creb3 factors activate genes 0 3 0.0 1.0
Met activates ptk2 signaling 0 19 0.0 1.0
Rab geranylgeranylation 0 54 0.0 1.0
Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation 0 5 0.0 1.0
Rrna processing in the mitochondrion 0 10 0.0 1.0
Tfap2 ap 2 family regulates transcription of cell cycle factors 0 5 0.0 1.0
Met receptor recycling 0 10 0.0 1.0
Tfap2 ap 2 family regulates transcription of growth factors and their receptors 0 7 0.0 1.0
Regulation of runx1 expression and activity 0 17 0.0 1.0
Digestion 0 1 0.0 1.0
Regulation of pten mrna translation 0 9 0.0 1.0
Regulation of runx3 expression and activity 1 52 1.989502871855813 0.4017902994798545
Runx3 regulates notch signaling 0 11 0.0 1.0
Runx3 regulates cdkn1a transcription 0 7 0.0 1.0
Runx2 regulates genes involved in cell migration 0 5 0.0 1.0
Runx2 regulates bone development 0 26 0.0 1.0
Runx2 regulates chondrocyte maturation 0 3 0.0 1.0
Runx2 regulates osteoblast differentiation 0 20 0.0 1.0
Regulation of runx2 expression and activity 2 61 3.471809062608094 0.1202677732034906
Receptor mediated mitophagy 0 10 0.0 1.0
Runx1 regulates transcription of genes involved in wnt signaling 0 3 0.0 1.0
Runx1 regulates transcription of genes involved in differentiation of myeloid cells 0 5 0.0 1.0
Runx1 regulates transcription of genes involved in bcr signaling 0 4 0.0 1.0
Runx1 interacts with co factors whose precise effect on runx1 targets is not known 0 36 0.0 1.0
Runx1 regulates transcription of genes involved in differentiation of keratinocytes 0 4 0.0 1.0
Runx1 regulates transcription of genes involved in differentiation of hscs 1 68 1.5119855269109 0.4895400608205746
Esr mediated signaling 0 136 0.0 1.0
Aryl hydrocarbon receptor signalling 0 7 0.0 1.0
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function 0 39 0.0 1.0
Runx1 regulates expression of components of tight junctions 0 4 0.0 1.0
Runx1 regulates transcription of genes involved in interleukin signaling 0 4 0.0 1.0
Activation of the tfap2 ap 2 family of transcription factors 0 8 0.0 1.0
Negative regulation of activity of tfap2 ap 2 family transcription factors 0 7 0.0 1.0
E3 ubiquitin ligases ubiquitinate target proteins 0 40 0.0 1.0
Synaptic adhesion like molecules 0 11 0.0 1.0
Ptk6 expression 0 2 0.0 1.0
Ptk6 regulates rho gtpases ras gtpase and map kinases 0 13 0.0 1.0
Ptk6 regulates cell cycle 0 5 0.0 1.0
Ptk6 regulates rtks and their effectors akt1 and dok1 0 7 0.0 1.0
Ptk6 regulates proteins involved in rna processing 0 3 0.0 1.0
Wax and plasmalogen biosynthesis 0 5 0.0 1.0
Signaling by ptk6 0 36 0.0 1.0
Erbb2 activates ptk6 signaling 0 3 0.0 1.0
Phosphate bond hydrolysis by ntpdase proteins 0 4 0.0 1.0
Gastrin creb signalling pathway via pkc and mapk 0 14 0.0 1.0
Advanced glycosylation endproduct receptor signaling 0 9 0.0 1.0
Regulation of ifng signaling 0 10 0.0 1.0
Interferon gamma signaling 0 51 0.0 1.0
The nlrp3 inflammasome 1 10 11.320987654320987 0.0938999510605359
Sumoylation of rna binding proteins 1 47 2.206851119894598 0.3714211816154574
Transport of fatty acids 0 3 0.0 1.0
Processing of intronless pre mrnas 0 21 0.0 1.0
Slbp dependent processing of replication dependent histone pre mrnas 0 10 0.0 1.0
Insulin receptor recycling 1 15 7.274170274170274 0.1375212864755611
Transport of organic anions 0 3 0.0 1.0
Butyrophilin btn family interactions 0 5 0.0 1.0
Signaling by fgfr2 iiia tm 0 18 0.0 1.0
Met activates ras signaling 0 11 0.0 1.0
Synthesis of active ubiquitin roles of e1 and e2 enzymes 0 26 0.0 1.0
Vldlr internalisation and degradation 0 9 0.0 1.0
Vldl assembly 0 3 0.0 1.0
Reelin signalling pathway 0 3 0.0 1.0
Met activates ptpn11 0 5 0.0 1.0
Transcriptional regulation by the ap 2 tfap2 family of transcription factors 0 27 0.0 1.0
Downregulation of erbb2 signaling 0 18 0.0 1.0
Ptk6 promotes hif1a stabilization 0 2 0.0 1.0
Clathrin mediated endocytosis 0 119 0.0 1.0
Cargo recognition for clathrin mediated endocytosis 0 78 0.0 1.0
Golgi to er retrograde transport 2 115 1.8029618927216904 0.3116411944565507
Interleukin 20 family signaling 0 11 0.0 1.0
Aurka activation by tpx2 0 73 0.0 1.0
Tbc rabgaps 0 39 0.0 1.0
Transcriptional regulation by ventx 0 37 0.0 1.0
Ret signaling 0 26 0.0 1.0
Signaling by fgfr3 fusions in cancer 0 10 0.0 1.0
Signaling by mst1 0 3 0.0 1.0
The role of gtse1 in g2 m progression after g2 checkpoint 1 67 1.5350474441383533 0.4844502219581325
Protein ubiquitination 0 58 0.0 1.0
Met activates pi3k akt signaling 0 6 0.0 1.0
Regulation of pten gene transcription 1 56 1.844077134986226 0.4250358756773005
Biosynthesis of maresins 0 1 0.0 1.0
Collagen chain trimerization 0 13 0.0 1.0
Regulation of pten localization 0 8 0.0 1.0
Rac1 gtpase cycle 1 152 0.6652618904274533 0.7789574534058219
Cdc42 gtpase cycle 1 134 0.7566643882433356 0.7353802816028594
Rhoc gtpase cycle 0 75 0.0 1.0
Rhob gtpase cycle 0 69 0.0 1.0
Rho gtpase cycle 3 387 0.7822164948453608 0.7374225393675994
Signaling by notch3 0 35 0.0 1.0
Robo receptors bind akap5 0 8 0.0 1.0
Regulation of expression of slits and robos 4 155 2.744205298013245 0.0658139566612362
Calnexin calreticulin cycle 0 23 0.0 1.0
Rac2 gtpase cycle 1 81 1.2646464646464646 0.5513512032975088
Er quality control compartment erqc 0 18 0.0 1.0
Interleukin 37 signaling 0 12 0.0 1.0
Rab regulation of trafficking 0 107 0.0 1.0
Signaling by tgfb family members 0 79 0.0 1.0
Signaling by receptor tyrosine kinases 2 344 0.5820503640052512 0.856163678469903
Signaling by nuclear receptors 1 178 0.5660560406323119 0.8296473015952495
Intracellular signaling by second messengers 2 233 0.8715434225638308 0.6706326039375146
Signaling by erythropoietin 0 19 0.0 1.0
Signaling by ntrk2 trkb 0 18 0.0 1.0
Loss of function of mecp2 in rett syndrome 0 12 0.0 1.0
Extra nuclear estrogen signaling 0 47 0.0 1.0
Transcriptional regulation by mecp2 0 45 0.0 1.0
Rhod gtpase cycle 0 50 0.0 1.0
Rhoh gtpase cycle 0 32 0.0 1.0
Biosynthesis of specialized proresolving mediators spms 0 6 0.0 1.0
Estrogen dependent gene expression 0 90 0.0 1.0
Noncanonical activation of notch3 0 8 0.0 1.0
Interleukin 36 pathway 0 1 0.0 1.0
Ticam1 traf6 dependent induction of tak1 complex 0 10 0.0 1.0
Ticam1 dependent activation of irf3 irf7 0 10 0.0 1.0
Tlr3 mediated ticam1 dependent programmed cell death 1 5 25.484848484848484 0.0480955538847994
Notch4 activation and transmission of signal to the nucleus 0 8 0.0 1.0
Notch4 intracellular domain regulates transcription 0 15 0.0 1.0
Rhoq gtpase cycle 0 59 0.0 1.0
Signaling by notch4 1 71 1.446753246753247 0.5045129832066302
Notch3 activation and transmission of signal to the nucleus 0 18 0.0 1.0
Rhot1 gtpase cycle 0 5 0.0 1.0
Rhov gtpase cycle 0 35 0.0 1.0
Rac3 gtpase cycle 1 83 1.2335550628233556 0.5601787468810149
Rhobtb1 gtpase cycle 0 22 0.0 1.0
Rhou gtpase cycle 0 39 0.0 1.0
Rhobtb2 gtpase cycle 0 22 0.0 1.0
Rhoj gtpase cycle 0 55 0.0 1.0
Rhog gtpase cycle 0 71 0.0 1.0
Notch3 intracellular domain regulates transcription 0 18 0.0 1.0
Interleukin 9 signaling 0 4 0.0 1.0
Interleukin 35 signalling 0 9 0.0 1.0
Oas antiviral response 0 6 0.0 1.0
Tyrosine catabolism 0 2 0.0 1.0
Metabolism of steroids 3 103 3.091546391752577 0.080334798270157
Nucleotide salvage 0 20 0.0 1.0
Nucleotide biosynthesis 0 16 0.0 1.0
Nucleotide catabolism 0 22 0.0 1.0
Carboxyterminal post translational modifications of tubulin 0 25 0.0 1.0
Cellular responses to stimuli 10 614 1.7461368653421634 0.0780020594765064
Metabolism of rna 10 647 1.6499215070643642 0.1016472334986816
Transcriptional regulation by e2f6 1 34 3.0801958983777165 0.2851312580635185
Phenylalanine and tyrosine metabolism 0 6 0.0 1.0
Runx3 regulates bcl2l11 bim transcription 0 5 0.0 1.0
Runx3 regulates yap1 mediated transcription 0 6 0.0 1.0
Neddylation 1 185 0.544137022397892 0.8412033375239305
Runx3 regulates wnt signaling 0 8 0.0 1.0
Gene and protein expression by jak stat signaling after interleukin 12 stimulation 1 33 3.176767676767677 0.2780273254227372
Processing of smdt1 0 16 0.0 1.0
Cristae formation 2 27 8.221224489795919 0.0285062952815799
Runx3 regulates immune response and cell migration 0 4 0.0 1.0
Mitochondrial calcium ion transport 2 21 10.823845327604726 0.0177148463510605
Regulation of pten stability and activity 1 63 1.634734441186054 0.4635835476922714
Runx3 regulates p14 arf 0 11 0.0 1.0
Aspartate and asparagine metabolism 0 7 0.0 1.0
Digestion and absorption 0 1 0.0 1.0
Chylomicron assembly 0 5 0.0 1.0
Interleukin 15 signaling 0 8 0.0 1.0
Glycogen metabolism 0 20 0.0 1.0
Rhoa gtpase cycle 1 134 0.7566643882433356 0.7353802816028594
Triglyceride metabolism 0 20 0.0 1.0
Metabolism of cofactors 1 15 7.274170274170274 0.1375212864755611
G beta gamma signalling through cdc42 0 14 0.0 1.0
Lipid particle organization 0 1 0.0 1.0
Glutamate and glutamine metabolism 0 14 0.0 1.0
Phenylalanine metabolism 0 4 0.0 1.0
Hdl remodeling 0 3 0.0 1.0
Vldl clearance 0 4 0.0 1.0
Plasma lipoprotein clearance 1 23 4.62534435261708 0.2030300441679912
Ldl remodeling 0 2 0.0 1.0
Ldl clearance 0 17 0.0 1.0
Chylomicron clearance 0 4 0.0 1.0
Hdl clearance 1 2 101.96969696969695 0.0195202957776364
Chylomicron remodeling 0 4 0.0 1.0
Plasma lipoprotein remodeling 0 12 0.0 1.0
Plasma lipoprotein assembly 0 12 0.0 1.0
Hdl assembly 0 6 0.0 1.0
Assembly of active lpl and lipc lipase complexes 0 7 0.0 1.0
Competing endogenous rnas cernas regulate pten translation 0 8 0.0 1.0
Thrombin signalling through proteinase activated receptors pars 0 21 0.0 1.0
Interleukin 6 signaling 0 8 0.0 1.0
Mitotic g1 phase and g1 s transition 1 143 0.708066581306018 0.7581385700495896
Gab1 signalosome 0 10 0.0 1.0
Darpp 32 events 0 20 0.0 1.0
Apc cdc20 mediated degradation of nek2a 0 25 0.0 1.0
Chondroitin sulfate dermatan sulfate metabolism 0 32 0.0 1.0
Signaling by egfr 0 40 0.0 1.0
Retrograde neurotrophin signalling 0 12 0.0 1.0
Interactions of rev with host cellular proteins 1 37 2.822671156004489 0.3060304729743218
Unwinding of dna 0 12 0.0 1.0
Phosphorylation of emi1 0 6 0.0 1.0
Shc1 events in egfr signaling 0 7 0.0 1.0
Phosphorylation of the apc c 0 20 0.0 1.0
Activation of atr in response to replication stress 0 38 0.0 1.0
Interactions of vpr with host cellular proteins 1 37 2.822671156004489 0.3060304729743218
Assembly of the hiv virion 0 15 0.0 1.0
Plasma lipoprotein assembly remodeling and clearance 1 40 2.6047656047656047 0.3263246311566628
Activation of c3 and c5 0 1 0.0 1.0
Telomere c strand synthesis initiation 0 13 0.0 1.0
Telomere c strand lagging strand synthesis 0 37 0.0 1.0
Processive synthesis on the c strand of the telomere 0 21 0.0 1.0
Polymerase switching on the c strand of the telomere 0 28 0.0 1.0
Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0 20 0.0 1.0
Glutathione synthesis and recycling 0 8 0.0 1.0
Apobec3g mediated resistance to hiv 1 infection 0 4 0.0 1.0
Extension of telomeres 0 52 0.0 1.0
Ngf independant trka activation 0 1 0.0 1.0
Activation of trka receptors 0 1 0.0 1.0
Signaling by pdgf 0 35 0.0 1.0
Downstream signal transduction 0 23 0.0 1.0
Regulation of beta cell development 0 22 0.0 1.0
Synthesis of ip3 and ip4 in the cytosol 0 20 0.0 1.0
Synthesis of ip2 ip and ins in the cytosol 0 12 0.0 1.0
Synthesis of pyrophosphates in the cytosol 1 10 11.320987654320987 0.0938999510605359
Organelle biogenesis and maintenance 5 268 1.9677806684010408 0.1230036620674163
Nuclear import of rev protein 1 34 3.0801958983777165 0.2851312580635185
Fgfr2 mutant receptor activation 0 18 0.0 1.0
Signaling by cytosolic fgfr1 fusion mutants 0 18 0.0 1.0
Cytosolic sensors of pathogen associated dna 1 56 1.844077134986226 0.4250358756773005
Sting mediated induction of host immune responses 0 10 0.0 1.0
Egfr downregulation 0 22 0.0 1.0
Nef mediated cd8 down regulation 0 6 0.0 1.0
Acetylcholine binding and downstream events 0 2 0.0 1.0
Norepinephrine neurotransmitter release cycle 0 12 0.0 1.0
Serotonin neurotransmitter release cycle 0 14 0.0 1.0
Rip mediated nfkb activation via zbp1 1 16 6.788552188552188 0.1459927402947744
Fgfr1 mutant receptor activation 0 22 0.0 1.0
Transport and synthesis of paps 0 4 0.0 1.0
Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 1 68 1.5119855269109 0.4895400608205746
Apc c mediated degradation of cell cycle proteins 1 81 1.2646464646464646 0.5513512032975088
Nef mediated cd4 down regulation 0 7 0.0 1.0
Hiv elongation arrest and recovery 0 32 0.0 1.0
Abortive elongation of hiv 1 transcript in the absence of tat 0 23 0.0 1.0
Transcription of the hiv genome 0 67 0.0 1.0
Hiv transcription elongation 0 42 0.0 1.0
Hiv transcription initiation 0 45 0.0 1.0
Signalling to ras 0 16 0.0 1.0
Terminal pathway of complement 0 1 0.0 1.0
Initial triggering of complement 0 1 0.0 1.0
The fatty acid cycling model 0 1 0.0 1.0
Complement cascade 0 10 0.0 1.0
The activation of arylsulfatases 1 8 14.558441558441558 0.0758460972151271
Mtorc1 mediated signalling 0 23 0.0 1.0
Mitochondrial uncoupling 0 1 0.0 1.0
Myd88 independent tlr4 cascade 2 78 2.690655209452202 0.1779321056766125
Glycosphingolipid metabolism 2 33 6.62606978275181 0.0412914524019695
Sphingolipid de novo biosynthesis 1 29 3.632034632034632 0.2489059409173845
Synthesis of pips at the late endosome membrane 0 10 0.0 1.0
Synthesis of pips at the early endosome membrane 1 16 6.788552188552188 0.1459927402947744
Synthesis of pips at the golgi membrane 1 15 7.274170274170274 0.1375212864755611
Signaling by ntrks 0 102 0.0 1.0
Trafficking and processing of endosomal tlr 0 8 0.0 1.0
Toll like receptor 9 tlr9 cascade 0 75 0.0 1.0
Toll like receptor tlr1 tlr2 cascade 0 70 0.0 1.0
Apc c cdc20 mediated degradation of cyclin b 0 23 0.0 1.0
Alternative complement activation 0 1 0.0 1.0
Telomere extension by telomerase 0 21 0.0 1.0
P38mapk events 0 13 0.0 1.0
Arms mediated activation 0 5 0.0 1.0
Signaling by tgf beta receptor complex 0 67 0.0 1.0
Regulation of glucokinase by glucokinase regulatory protein 1 31 3.3892255892255894 0.2636091346473535
Adenylate cyclase inhibitory pathway 0 6 0.0 1.0
Adenylate cyclase activating pathway 0 3 0.0 1.0
Prolonged erk activation events 0 12 0.0 1.0
Ddx58 ifih1 mediated induction of interferon alpha beta 1 57 1.810966810966811 0.4307061333231872
Ticam1 rip1 mediated ikk complex recruitment 1 16 6.788552188552188 0.1459927402947744
Toll like receptor cascades 2 103 2.019599919175591 0.2680066972469274
Neurotoxicity of clostridium toxins 0 8 0.0 1.0
Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 1 42 2.477211135747721 0.339526513295544
Nod1 2 signaling pathway 0 30 0.0 1.0
Viral messenger rna synthesis 1 44 2.361522198731501 0.3524722176470324
Ns1 mediated effects on host pathways 1 40 2.6047656047656047 0.3263246311566628
Export of viral ribonucleoproteins from nucleus 1 32 3.2795698924731185 0.27085351108605
Influenza infection 4 150 2.8396118721461185 0.05977481033742
Innate immune system 9 624 1.5246850710265345 0.1579036891945946
Scf skp2 mediated degradation of p27 p21 1 54 1.9140461215932916 0.4135270958140081
Signalling to erks 0 30 0.0 1.0
Signalling to p38 via rit and rin 0 3 0.0 1.0
Cellular hexose transport 0 6 0.0 1.0
Signaling by bmp 0 15 0.0 1.0
Trans golgi network vesicle budding 0 69 0.0 1.0
Membrane trafficking 3 532 0.5593319431722955 0.8999155647784952
Er to golgi anterograde transport 3 129 2.447226313205695 0.1330503697063572
Creb phosphorylation 0 7 0.0 1.0
Negative regulation of the pi3k akt network 0 62 0.0 1.0
Vitamin b5 pantothenate metabolism 0 13 0.0 1.0
Immunoregulatory interactions between a lymphoid and a non lymphoid cell 0 26 0.0 1.0
Erk mapk targets 0 20 0.0 1.0
Signaling by alk 0 19 0.0 1.0
Nuclear events kinase and transcription factor activation 0 42 0.0 1.0
Akt phosphorylates targets in the cytosol 0 14 0.0 1.0
Pi3k akt activation 0 7 0.0 1.0
Signaling by notch2 0 22 0.0 1.0
Signaling by notch1 0 56 0.0 1.0
Nicotinamide salvaging 0 11 0.0 1.0
A tetrasaccharide linker sequence is required for gag synthesis 0 16 0.0 1.0
Metabolism of vitamins and cofactors 2 134 1.5405071119356837 0.3794730020368597
Metabolism of water soluble vitamins and cofactors 1 91 1.1230078563411896 0.5938019181425528
Vitamin b2 riboflavin metabolism 0 4 0.0 1.0
Akt phosphorylates targets in the nucleus 0 9 0.0 1.0
Tcf dependent signaling in response to wnt 1 142 0.7131599684791174 0.7557087787032648
Wnt mediated activation of dvl 0 8 0.0 1.0
Formation of the beta catenin tcf transactivating complex 0 38 0.0 1.0
Yap1 and wwtr1 taz stimulated gene expression 0 10 0.0 1.0
Role of phospholipids in phagocytosis 0 16 0.0 1.0
Fcgr activation 0 5 0.0 1.0
Fcgamma receptor fcgr dependent phagocytosis 1 72 1.426234172713046 0.5094066821340305
Signaling by hippo 0 21 0.0 1.0
Cell surface interactions at the vascular wall 0 70 0.0 1.0
Erks are inactivated 0 11 0.0 1.0
Calcineurin activates nfat 0 8 0.0 1.0
Generation of second messenger molecules 0 11 0.0 1.0
Cs ds degradation 0 7 0.0 1.0
Hs gag degradation 0 17 0.0 1.0
Tcr signaling 1 85 1.203944203944204 0.5688343041108967
Hs gag biosynthesis 0 17 0.0 1.0
Dermatan sulfate biosynthesis 0 6 0.0 1.0
Chondroitin sulfate biosynthesis 0 12 0.0 1.0
Keratan sulfate degradation 0 6 0.0 1.0
Keratan sulfate biosynthesis 0 11 0.0 1.0
Metabolism of angiotensinogen to angiotensins 0 8 0.0 1.0
Assembly of collagen fibrils and other multimeric structures 0 28 0.0 1.0
Metabolism of nitric oxide nos3 activation and regulation 0 10 0.0 1.0
G protein activation 0 13 0.0 1.0
Vitamin c ascorbate metabolism 0 6 0.0 1.0
Synthesis of pips at the plasma membrane 1 47 2.206851119894598 0.3714211816154574
Vitamin b1 thiamin metabolism 0 5 0.0 1.0
Vitamin d calciferol metabolism 0 8 0.0 1.0
Androgen biosynthesis 0 2 0.0 1.0
Synthesis of bile acids and bile salts 0 20 0.0 1.0
Snrnp assembly 2 53 4.019607843137255 0.0951370618475993
Cholesterol biosynthesis 2 24 9.34508348794063 0.0228441699597423
Pre notch expression and processing 1 50 2.0711193568336426 0.3898210156705143
Pre notch processing in golgi 0 13 0.0 1.0
Pre notch processing in the endoplasmic reticulum 1 5 25.484848484848484 0.0480955538847994
Gap junction degradation 0 12 0.0 1.0
Transport of connexons to the plasma membrane 0 14 0.0 1.0
Estrogen biosynthesis 0 2 0.0 1.0
Gap junction assembly 0 15 0.0 1.0
Fgfr2c ligand binding and activation 0 2 0.0 1.0
Fgfr1c ligand binding and activation 0 2 0.0 1.0
Fgfr3b ligand binding and activation 0 1 0.0 1.0
Fgfr1b ligand binding and activation 0 2 0.0 1.0
Fgfr1 ligand binding and activation 0 2 0.0 1.0
Fgfr2 ligand binding and activation 0 2 0.0 1.0
Fgfr3 ligand binding and activation 0 3 0.0 1.0
Signaling by fgfr 0 57 0.0 1.0
Heme biosynthesis 0 12 0.0 1.0
Fgfr2b ligand binding and activation 0 2 0.0 1.0
Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol 0 13 0.0 1.0
P75ntr signals via nf kb 0 14 0.0 1.0
Nrage signals death through jnk 0 47 0.0 1.0
Coenzyme a biosynthesis 0 8 0.0 1.0
Biotin transport and metabolism 0 11 0.0 1.0
Metabolism of folate and pterines 1 15 7.274170274170274 0.1375212864755611
Cobalamin cbl vitamin b12 transport and metabolism 0 13 0.0 1.0
Pi3k events in erbb2 signaling 0 7 0.0 1.0
Grb2 events in erbb2 signaling 0 7 0.0 1.0
Beta catenin phosphorylation cascade 0 16 0.0 1.0
Pregnenolone biosynthesis 1 8 14.558441558441558 0.0758460972151271
Metabolism of steroid hormones 1 12 9.26078971533517 0.1116045715736199
Signaling by wnt 1 213 0.4709357728225652 0.8801615941747158
Rho gtpase effectors 4 246 1.6966253443526171 0.22177281745075
Degradation of beta catenin by the destruction complex 1 77 1.331738437001595 0.5331665625078387
Vegf ligand receptor interactions 0 2 0.0 1.0
Signaling by vegf 1 87 1.1757105943152455 0.5773211926082669
Bile acid and bile salt metabolism 0 22 0.0 1.0
Synthesis of bile acids and bile salts via 27 hydroxycholesterol 0 7 0.0 1.0
Synthesis of bile acids and bile salts via 24 hydroxycholesterol 0 5 0.0 1.0
P75 ntr receptor mediated signalling 0 81 0.0 1.0
P75ntr regulates axonogenesis 0 5 0.0 1.0
Regulated proteolysis of p75ntr 0 11 0.0 1.0
P75ntr negatively regulates cell cycle via sc1 0 5 0.0 1.0
Nicotinate metabolism 0 18 0.0 1.0
Enos activation 0 7 0.0 1.0
Regulation of cholesterol biosynthesis by srebp srebf 1 55 1.878413767302656 0.4193097117028734
Collagen biosynthesis and modifying enzymes 0 30 0.0 1.0
Shc1 events in erbb2 signaling 0 13 0.0 1.0
Erythrocytes take up oxygen and release carbon dioxide 0 1 0.0 1.0
Methionine salvage pathway 1 6 20.385858585858585 0.0574361921538736
Erythrocytes take up carbon dioxide and release oxygen 0 4 0.0 1.0
Cross presentation of soluble exogenous antigens endosomes 1 41 2.5393939393939395 0.3329579057594876
Endosomal vacuolar pathway 0 10 0.0 1.0
Antigen processing cross presentation 2 77 2.726802721088436 0.1744223041589415
Cross presentation of particulate exogenous antigens phagosomes 0 3 0.0 1.0
Signaling by erbb4 0 36 0.0 1.0
Pi3k events in erbb4 signaling 0 2 0.0 1.0
Constitutive signaling by ligand responsive egfr cancer variants 0 17 0.0 1.0
Regulation of gene expression by hypoxia inducible factor 0 5 0.0 1.0
Signaling by erbb2 in cancer 0 17 0.0 1.0
Signaling by erbb2 0 37 0.0 1.0
Signaling by fgfr in disease 0 48 0.0 1.0
Ros and rns production in phagocytes 1 16 6.788552188552188 0.1459927402947744
Meiotic synapsis 0 31 0.0 1.0
Fertilization 0 3 0.0 1.0
Signaling by nodal 0 12 0.0 1.0
Prolactin receptor signaling 0 9 0.0 1.0
Cellular response to hypoxia 1 59 1.748171368861024 0.4418810858922499
Antiviral mechanism by ifn stimulated genes 1 73 1.4062850729517395 0.5142525268330266
Shc1 events in erbb4 signaling 0 6 0.0 1.0
Downregulation of erbb4 signaling 0 7 0.0 1.0
Elevation of cytosolic ca2 levels 0 6 0.0 1.0
Abc transporters in lipid homeostasis 0 7 0.0 1.0
Bmal1 clock npas2 activates circadian gene expression 0 20 0.0 1.0
Rora activates gene expression 0 17 0.0 1.0
Mitochondrial iron sulfur cluster biogenesis 0 12 0.0 1.0
Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1 0 16 0.0 1.0
Transcription of e2f targets under negative control by dream complex 0 19 0.0 1.0
Downregulation of erbb2 erbb3 signaling 0 10 0.0 1.0
Grb7 events in erbb2 signaling 0 2 0.0 1.0
Nuclear signaling by erbb4 0 18 0.0 1.0
Acrosome reaction and sperm oocyte membrane binding 0 1 0.0 1.0
Tandem pore domain potassium channels 0 2 0.0 1.0
Voltage gated potassium channels 0 2 0.0 1.0
Potassium channels 0 15 0.0 1.0
Inwardly rectifying k channels 0 12 0.0 1.0
Spry regulation of fgf signaling 0 14 0.0 1.0
Adaptive immune system 7 504 1.4537331515977585 0.2247945442074981
Cytokine signaling in immune system 4 392 1.0425257731958764 0.5397867020054197
Developmental biology 6 665 0.9140541762179965 0.6426960877113572
Interleukin 7 signaling 0 13 0.0 1.0
Sperm motility and taxes 0 1 0.0 1.0
Activation of ras in b cells 0 3 0.0 1.0
Downstream signaling events of b cell receptor bcr 1 71 1.446753246753247 0.5045129832066302
Gpvi mediated activation cascade 0 21 0.0 1.0
Smac xiap regulated apoptotic response 0 8 0.0 1.0
Apoptotic cleavage of cellular proteins 0 35 0.0 1.0
Cytochrome c mediated apoptotic response 0 13 0.0 1.0
Activation of caspases through apoptosome mediated cleavage 0 6 0.0 1.0
Formation of apoptosome 0 11 0.0 1.0
Release of apoptotic factors from the mitochondria 0 6 0.0 1.0
Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members 0 8 0.0 1.0
Activation of noxa and translocation to mitochondria 0 5 0.0 1.0
Activation of bad and translocation to mitochondria 0 16 0.0 1.0
Apoptotic factor mediated response 0 20 0.0 1.0
Resolution of ap sites via the multiple nucleotide patch replacement pathway 0 28 0.0 1.0
Displacement of dna glycosylase by apex1 0 8 0.0 1.0
Recognition and association of dna glycosylase with site containing an affected purine 0 16 0.0 1.0
Translesion synthesis by polh 0 20 0.0 1.0
Recognition of dna damage by pcna containing replication complex 1 30 3.506443747823058 0.2562935091164666
Translesion synthesis by y family dna polymerases bypasses lesions on dna template 0 41 0.0 1.0
Mapk3 erk1 activation 0 8 0.0 1.0
Intrinsic pathway for apoptosis 1 53 1.951048951048951 0.4076874771235006
Hemostasis 3 361 0.8412716696423429 0.6930079334563264
Apoptosis 3 159 1.97065820777161 0.2047370877292106
Polb dependent long patch base excision repair 0 9 0.0 1.0
Opioid signalling 0 63 0.0 1.0
Pka mediated phosphorylation of creb 0 13 0.0 1.0
Camk iv mediated phosphorylation of creb 0 8 0.0 1.0
Disinhibition of snare formation 0 4 0.0 1.0
Effects of pip2 hydrolysis 0 17 0.0 1.0
Activation of bh3 only proteins 1 29 3.632034632034632 0.2489059409173845
E2f mediated regulation of dna replication 0 23 0.0 1.0
E2f enabled inhibition of pre replication complex formation 0 10 0.0 1.0
Inhibition of replication initiation of damaged dna by rb1 e2f1 0 13 0.0 1.0
Formation of the early elongation complex 0 33 0.0 1.0
Sos mediated signalling 0 7 0.0 1.0
Mapk1 erk2 activation 0 7 0.0 1.0
Raf independent mapk1 3 activation 0 15 0.0 1.0
Irs mediated signalling 0 26 0.0 1.0
Formation of rna pol ii elongation complex 0 58 0.0 1.0
Neuronal system 0 177 0.0 1.0
Transmission across chemical synapses 0 139 0.0 1.0
Neurotransmitter receptors and postsynaptic signal transmission 0 105 0.0 1.0
Neurotransmitter clearance 0 3 0.0 1.0
Neurotransmitter release cycle 0 30 0.0 1.0
Presynaptic depolarization and calcium channel opening 0 4 0.0 1.0
Electric transmission across gap junctions 0 2 0.0 1.0
G protein mediated events 0 40 0.0 1.0
Ca dependent events 0 26 0.0 1.0
Activation of puma and translocation to mitochondria 0 8 0.0 1.0
Apoptosis induced dna fragmentation 0 11 0.0 1.0
Caspase activation via death receptors in the presence of ligand 1 11 10.187878787878788 0.1027954944442906
Extrinsic pathway of fibrin clot formation 0 1 0.0 1.0
Golgi cisternae pericentriolar stack reorganization 0 14 0.0 1.0
Early phase of hiv life cycle 0 13 0.0 1.0
Integration of provirus 0 9 0.0 1.0
Budding and maturation of hiv virion 0 27 0.0 1.0
Hiv life cycle 1 144 0.7030444303171576 0.7605444332681799
Sulfur amino acid metabolism 1 22 4.846079846079846 0.1951188871774342
Degradation of cysteine and homocysteine 0 12 0.0 1.0
Sulfide oxidation to sulfate 0 5 0.0 1.0
Irf3 mediated activation of type 1 ifn 0 3 0.0 1.0
Synthesis of glycosylphosphatidylinositol gpi 0 12 0.0 1.0
Zbp1 dai mediated induction of type i ifns 1 18 5.98871063576946 0.1626892876910785
Removal of aminoterminal propeptides from gamma carboxylated proteins 0 4 0.0 1.0
Recycling of bile acids and salts 0 6 0.0 1.0
Activation of matrix metalloproteinases 0 6 0.0 1.0
Transport of mature mrnas derived from intronless transcripts 1 43 2.417989417989418 0.3460310778663031
Transport of the slbp dependant mature mrna 1 36 2.903607503607504 0.299132167535026
Metabolism of nucleotides 0 82 0.0 1.0
Gap junction trafficking and regulation 0 28 0.0 1.0
Telomere maintenance 0 74 0.0 1.0
Signaling by notch 2 152 1.3531972789115647 0.441114647154086
Gamma carboxylation transport and amino terminal cleavage of proteins 0 5 0.0 1.0
Attachment of gpi anchor to upar 0 7 0.0 1.0
Hiv infection 2 213 0.9560885965760711 0.6219100721739275
Host interactions of hiv factors 2 116 1.786967418546366 0.315260036101858
The role of nef in hiv 1 replication and disease pathogenesis 0 20 0.0 1.0
Nef and signal transduction 0 4 0.0 1.0
Nef mediated downregulation of mhc class i complex cell surface expression 0 9 0.0 1.0
Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 0 16 0.0 1.0
2 ltr circle formation 0 7 0.0 1.0
Pka activation in glucagon signalling 0 12 0.0 1.0
Signaling by egfr in cancer 0 17 0.0 1.0
Cell cycle 5 613 0.8213296398891967 0.7261911338415823
Gamma carboxylation hypusine formation and arylsulfatase activation 2 29 7.610733182161754 0.0325598174288622
Heparan sulfate heparin hs gag metabolism 0 32 0.0 1.0
Keratan sulfate keratin metabolism 0 17 0.0 1.0
Pp2a mediated dephosphorylation of key metabolic factors 0 6 0.0 1.0
Chrebp activates metabolic gene expression 0 8 0.0 1.0
Integration of energy metabolism 0 71 0.0 1.0
Ampk inhibits chrebp transcriptional activation activity 0 7 0.0 1.0
Triglyceride catabolism 0 13 0.0 1.0
Glucagon signaling in metabolic regulation 0 21 0.0 1.0
Pka mediated phosphorylation of key metabolic factors 0 4 0.0 1.0
Formation of atp by chemiosmotic coupling 1 14 7.834498834498834 0.1289666473793992
Post translational modification synthesis of gpi anchored proteins 0 32 0.0 1.0
Glycosaminoglycan metabolism 0 70 0.0 1.0
Eukaryotic translation elongation 3 89 3.5998561496044115 0.0567924573004668
Mtor signalling 0 39 0.0 1.0
Polo like kinase mediated events 0 16 0.0 1.0
Elastic fibre formation 0 23 0.0 1.0
Acyl chain remodelling of ps 0 9 0.0 1.0
Acyl chain remodeling of cl 0 5 0.0 1.0
Acyl chain remodelling of pc 0 9 0.0 1.0
Reversible hydration of carbon dioxide 0 2 0.0 1.0
Collagen formation 0 44 0.0 1.0
Extracellular matrix organization 0 131 0.0 1.0
Degradation of the extracellular matrix 0 56 0.0 1.0
Reproduction 0 57 0.0 1.0
Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation 0 7 0.0 1.0
Acyl chain remodelling of pe 0 8 0.0 1.0
Alpha defensins 0 1 0.0 1.0
Translocation of slc2a4 glut4 to the plasma membrane 0 66 0.0 1.0
Collagen degradation 0 21 0.0 1.0
Regulation of signaling by nodal 0 3 0.0 1.0
Regulation of kit signaling 0 12 0.0 1.0
Signaling by scf kit 0 31 0.0 1.0
Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components 0 21 0.0 1.0
Formation of fibrin clot clotting cascade 1 9 12.737373737373735 0.0849171013653387
Common pathway of fibrin clot formation 0 5 0.0 1.0
Intrinsic pathway of fibrin clot formation 1 7 16.986531986531986 0.0666860823201616
Defensins 0 1 0.0 1.0
Acyl chain remodeling of dag and tag 0 2 0.0 1.0
Acyl chain remodelling of pi 0 4 0.0 1.0
Acyl chain remodelling of pg 0 7 0.0 1.0
Glutathione conjugation 0 21 0.0 1.0
Glucuronidation 1 4 33.98316498316498 0.0386632862857637
Cytosolic sulfonation of small molecules 0 14 0.0 1.0
Methylation 0 12 0.0 1.0
Phase ii conjugation of compounds 1 53 1.951048951048951 0.4076874771235006
G0 and early g1 0 26 0.0 1.0
Signaling by activin 0 9 0.0 1.0
Cell cell communication 1 79 1.2973322973322974 0.5423482911753763
Meiosis 0 54 0.0 1.0
Dag and ip3 signaling 0 30 0.0 1.0
Phospholipid metabolism 1 156 0.6478331704138156 0.7876311026335139
Pi metabolism 1 71 1.446753246753247 0.5045129832066302
Inositol phosphate metabolism 1 40 2.6047656047656047 0.3263246311566628
Synthesis of pips at the er membrane 0 5 0.0 1.0
Synthesis of pi 0 5 0.0 1.0
Synthesis of pe 0 12 0.0 1.0
Glycerophospholipid biosynthesis 0 86 0.0 1.0
Synthesis of pc 0 22 0.0 1.0
Synthesis of pa 0 25 0.0 1.0
Synthesis of pg 0 8 0.0 1.0
Hydrolysis of lpc 0 3 0.0 1.0
Fibronectin matrix formation 0 3 0.0 1.0
Sumoylation of chromatin organization proteins 1 58 1.7790182527024632 0.4363210249842685
Nostrin mediated enos trafficking 0 3 0.0 1.0
Copii mediated vesicle transport 1 55 1.878413767302656 0.4193097117028734
Sema4d in semaphorin signaling 0 23 0.0 1.0
Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip 0 9 0.0 1.0
Incretin synthesis secretion and inactivation 0 14 0.0 1.0
Free fatty acids regulate insulin secretion 0 8 0.0 1.0
Circadian clock 0 55 0.0 1.0
Regulation of lipid metabolism by pparalpha 3 95 3.3630658897355445 0.0664204872480981
Adrenaline noradrenaline inhibits insulin secretion 0 16 0.0 1.0
Acetylcholine regulates insulin secretion 0 8 0.0 1.0
Crmps in sema3a signaling 0 12 0.0 1.0
Sialic acid metabolism 0 16 0.0 1.0
Sema3a plexin repulsion signaling by inhibiting integrin adhesion 0 10 0.0 1.0
Trafficking of ampa receptors 0 20 0.0 1.0
G protein beta gamma signalling 0 22 0.0 1.0
Muscle contraction 1 83 1.2335550628233556 0.5601787468810149
Eph ephrin mediated repulsion of cells 0 43 0.0 1.0
Ephrin signaling 0 17 0.0 1.0
Epha mediated growth cone collapse 0 23 0.0 1.0
Ephb mediated forward signaling 0 40 0.0 1.0
Prostacyclin signalling through prostacyclin receptor 0 12 0.0 1.0
Signal amplification 0 22 0.0 1.0
Sema3a pak dependent axon repulsion 0 13 0.0 1.0
Rap1 signalling 0 13 0.0 1.0
Sumoylation of sumoylation proteins 1 35 2.989304812834225 0.2921659829416722
Pcp ce pathway 1 78 1.3143119506755871 0.5377799970023095
Caspase activation via dependence receptors in the absence of ligand 0 7 0.0 1.0
Netrin mediated repulsion signals 0 5 0.0 1.0
Dcc mediated attractive signaling 0 13 0.0 1.0
G alpha z signalling events 0 28 0.0 1.0
G alpha i signalling events 1 88 1.1620805758736794 0.5815024054643041
Adp signalling through p2y purinoceptor 1 0 17 0.0 1.0
G alpha s signalling events 0 37 0.0 1.0
Cgmp effects 0 7 0.0 1.0
Platelet calcium homeostasis 1 13 8.488215488215488 0.1203280145079081
Ca2 pathway 0 45 0.0 1.0
Reduction of cytosolic ca levels 1 7 16.986531986531986 0.0666860823201616
Nucleotide like purinergic receptors 0 1 0.0 1.0
P2y receptors 0 1 0.0 1.0
Trafficking of glur2 containing ampa receptors 0 11 0.0 1.0
Other semaphorin interactions 0 7 0.0 1.0
Sema4d induced cell migration and growth cone collapse 0 18 0.0 1.0
Sema4d mediated inhibition of cell attachment and migration 0 8 0.0 1.0
G alpha 12 13 signalling events 0 57 0.0 1.0
G alpha q signalling events 0 66 0.0 1.0
Sumoylation of intracellular receptors 0 18 0.0 1.0
Platelet homeostasis 1 51 2.029494949494949 0.3958350013250431
G beta gamma signalling through pi3kgamma 0 15 0.0 1.0
Adp signalling through p2y purinoceptor 12 0 13 0.0 1.0
Nitric oxide stimulates guanylate cyclase 0 11 0.0 1.0
Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 0 12 0.0 1.0
Olfactory signaling pathway 0 2 0.0 1.0
Glucagon like peptide 1 glp1 regulates insulin secretion 0 27 0.0 1.0
Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0 56 0.0 1.0
Transcriptional regulation of white adipocyte differentiation 1 68 1.5119855269109 0.4895400608205746
Atf6 atf6 alpha activates chaperone genes 0 6 0.0 1.0
Unfolded protein response upr 1 75 1.368004368004368 0.523802502209471
Ire1alpha activates chaperones 1 44 2.361522198731501 0.3524722176470324
Perk regulates gene expression 0 26 0.0 1.0
Abc family proteins mediated transport 1 75 1.368004368004368 0.523802502209471
Atf6 atf6 alpha activates chaperones 0 8 0.0 1.0
Energy dependent regulation of mtor by lkb1 ampk 0 27 0.0 1.0
Recruitment of numa to mitotic centrosomes 0 90 0.0 1.0
Recruitment of mitotic centrosome proteins and complexes 0 82 0.0 1.0
Chemokine receptors bind chemokines 0 3 0.0 1.0
Mitochondrial trna aminoacylation 0 23 0.0 1.0
Trna aminoacylation 0 43 0.0 1.0
Cytosolic trna aminoacylation 0 24 0.0 1.0
Dopamine clearance from the synaptic cleft 0 2 0.0 1.0
Myoclonic epilepsy of lafora 0 5 0.0 1.0
Atf4 activates genes in response to endoplasmic reticulum stress 0 22 0.0 1.0
Nuclear receptor transcription pathway 1 29 3.632034632034632 0.2489059409173845
Beta catenin independent wnt signaling 1 117 0.869035179380007 0.6864562302095232
Costimulation by the cd28 family 0 39 0.0 1.0
Protein folding 0 79 0.0 1.0
Signal regulatory protein family interactions 0 9 0.0 1.0
Peroxisomal lipid metabolism 1 24 4.423803249890207 0.2108642126213972
Diseases associated with o glycosylation of proteins 0 17 0.0 1.0
Striated muscle contraction 0 16 0.0 1.0
Association of tric cct with target proteins during biosynthesis 0 36 0.0 1.0
Folding of actin by cct tric 0 10 0.0 1.0
Beta oxidation of very long chain fatty acids 0 9 0.0 1.0
Post chaperonin tubulin folding pathway 0 18 0.0 1.0
Formation of tubulin folding intermediates by cct tric 0 21 0.0 1.0
Cooperation of prefoldin and tric cct in actin and tubulin folding 0 28 0.0 1.0
Pd 1 signaling 0 5 0.0 1.0
Sumoylation of transcription cofactors 1 41 2.5393939393939395 0.3329579057594876
Beta oxidation of pristanoyl coa 0 7 0.0 1.0
Glyoxylate metabolism and glycine degradation 0 22 0.0 1.0
Alpha oxidation of phytanate 1 6 20.385858585858585 0.0574361921538736
Ctla4 inhibitory signaling 0 17 0.0 1.0
Cd28 dependent vav1 pathway 0 7 0.0 1.0
Cd28 dependent pi3k akt signaling 0 15 0.0 1.0
Cd28 co stimulation 0 24 0.0 1.0
Receptor type tyrosine protein phosphatases 0 11 0.0 1.0
Role of second messengers in netrin 1 signaling 0 3 0.0 1.0
Adherens junctions interactions 0 18 0.0 1.0
Ncam1 interactions 0 15 0.0 1.0
Lysosphingolipid and lpa receptors 0 3 0.0 1.0
Regulation of cytoskeletal remodeling and cell spreading by ipp complex components 1 7 16.986531986531986 0.0666860823201616
Cell extracellular matrix interactions 1 16 6.788552188552188 0.1459927402947744
Synthesis of substrates in n glycan biosythesis 0 44 0.0 1.0
Synthesis of udp n acetyl glucosamine 0 8 0.0 1.0
Synthesis of gdp mannose 0 5 0.0 1.0
Asparagine n linked glycosylation 4 245 1.7038381742738589 0.2196953406871454
Synthesis of dolichyl phosphate 0 5 0.0 1.0
Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 1 59 1.748171368861024 0.4418810858922499
Type i hemidesmosome assembly 0 9 0.0 1.0
Interleukin 1 family signaling 1 95 1.0747904577691811 0.6096462186358106
Tak1 activates nfkb by phosphorylation and activation of ikks complex 0 25 0.0 1.0
Smooth muscle contraction 0 28 0.0 1.0
Signal transduction by l1 0 20 0.0 1.0
Interaction between l1 and ankyrins 0 12 0.0 1.0
Formyl peptide receptors bind formyl peptides and many other ligands 0 3 0.0 1.0
Rsk activation 0 7 0.0 1.0
Ras activation upon ca2 influx through nmda receptor 0 13 0.0 1.0
Activation of nmda receptors and postsynaptic events 0 68 0.0 1.0
Creb1 phosphorylation through nmda receptor mediated activation of ras signaling 0 21 0.0 1.0
Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde 0 7 0.0 1.0
Aquaporin mediated transport 0 26 0.0 1.0
Cell junction organization 1 54 1.9140461215932916 0.4135270958140081
Nrcam interactions 0 7 0.0 1.0
Chl1 interactions 0 7 0.0 1.0
Mitotic g2 g2 m phases 1 186 0.5411411411411411 0.8427895593060013
Transcriptional regulation of pluripotent stem cells 0 16 0.0 1.0
Interleukin 2 family signaling 0 21 0.0 1.0
Signaling by the b cell receptor bcr 1 91 1.1230078563411896 0.5938019181425528
Ionotropic activity of kainate receptors 0 3 0.0 1.0
Ksrp khsrp binds and destabilizes mrna 0 17 0.0 1.0
Regulation of mrna stability by proteins that bind au rich elements 1 79 1.2973322973322974 0.5423482911753763
Hur elavl1 binds and stabilizes mrna 0 7 0.0 1.0
Tristetraprolin ttp zfp36 binds and destabilizes mrna 0 17 0.0 1.0
Auf1 hnrnp d0 binds and destabilizes mrna 1 48 2.1596819256393727 0.3776146865857887
Butyrate response factor 1 brf1 binds and destabilizes mrna 0 17 0.0 1.0
Activation of the ap 1 family of transcription factors 0 8 0.0 1.0
Jnk c jun kinases phosphorylation and activation mediated by activated human tak1 0 18 0.0 1.0
Activated tak1 mediates p38 mapk activation 0 20 0.0 1.0
Mapk targets nuclear events mediated by map kinases 0 27 0.0 1.0
Other interleukin signaling 0 12 0.0 1.0
Signaling by interleukins 3 248 1.2435514411950348 0.4406224335053858
Interleukin 1 processing 0 3 0.0 1.0
Interleukin 17 signaling 0 57 0.0 1.0
Interleukin 12 family signaling 1 43 2.417989417989418 0.3460310778663031
Neurofascin interactions 0 6 0.0 1.0
Creb1 phosphorylation through the activation of adenylate cyclase 0 9 0.0 1.0
Diseases of glycosylation 1 76 1.3496296296296295 0.5285075461630524
Na cl dependent neurotransmitter transporters 0 4 0.0 1.0
Depolymerisation of the nuclear lamina 0 16 0.0 1.0
Multifunctional anion exchangers 0 3 0.0 1.0
Ercc6 csb and ehmt2 g9a positively regulate rrna expression 0 27 0.0 1.0
Sirt1 negatively regulates rrna expression 0 18 0.0 1.0
Small interfering rna sirna biogenesis 0 9 0.0 1.0
Cation coupled chloride cotransporters 0 4 0.0 1.0
Arachidonate production from dag 0 4 0.0 1.0
Sodium proton exchangers 0 4 0.0 1.0
Sodium calcium exchangers 0 3 0.0 1.0
Metal ion slc transporters 0 15 0.0 1.0
Sodium coupled phosphate cotransporters 0 2 0.0 1.0
Slc mediated transmembrane transport 1 101 1.0096969696969698 0.6322723581240091
Transport of inorganic cations anions and amino acids oligopeptides 1 44 2.361522198731501 0.3524722176470324
Bicarbonate transporters 0 4 0.0 1.0
Transport of bile salts and organic acids metal ions and amine compounds 0 32 0.0 1.0
Regulation of insulin secretion 0 48 0.0 1.0
Synthesis secretion and deacylation of ghrelin 0 5 0.0 1.0
Cell cell junction organization 0 31 0.0 1.0
Nectin necl trans heterodimerization 0 5 0.0 1.0
Glucagon type ligand receptors 0 13 0.0 1.0
Tight junction interactions 0 11 0.0 1.0
Transport of vitamins nucleosides and related molecules 0 21 0.0 1.0
Sphingolipid metabolism 3 62 5.261401362921545 0.0228098510804851
Activation of rac1 0 12 0.0 1.0
Regulation of commissural axon pathfinding by slit and robo 0 7 0.0 1.0
Binding of tcf lef ctnnb1 to target gene promoters 0 7 0.0 1.0
Unblocking of nmda receptors glutamate binding and activation 0 9 0.0 1.0
Recycling pathway of l1 0 41 0.0 1.0
Zinc efflux and compartmentalization by the slc30 family 0 5 0.0 1.0
Zinc transporters 0 12 0.0 1.0
Fatty acids bound to gpr40 ffar1 regulate insulin secretion 0 6 0.0 1.0
Proton coupled monocarboxylate transport 0 4 0.0 1.0
Golgi associated vesicle biogenesis 0 55 0.0 1.0
Lysosome vesicle biogenesis 0 32 0.0 1.0
Platelet sensitization by ldl 0 15 0.0 1.0
Passive transport by aquaporins 0 1 0.0 1.0
Vasopressin regulates renal water homeostasis via aquaporins 0 25 0.0 1.0
Gp1b ix v activation signalling 0 7 0.0 1.0
Mrna decay by 5 to 3 exoribonuclease 0 15 0.0 1.0
Mrna decay by 3 to 5 exoribonuclease 1 16 6.788552188552188 0.1459927402947744
Deadenylation of mrna 0 26 0.0 1.0
Deadenylation dependent mrna decay 1 57 1.810966810966811 0.4307061333231872
Thromboxane signalling through tp receptor 0 15 0.0 1.0
Role of abl in robo slit signaling 0 9 0.0 1.0
Organic anion transporters 0 3 0.0 1.0
Inactivation of cdc42 and rac1 0 8 0.0 1.0
Zinc influx into cells by the slc39 gene family 0 7 0.0 1.0
Microrna mirna biogenesis 0 24 0.0 1.0
Diseases associated with n glycosylation of proteins 1 18 5.98871063576946 0.1626892876910785
Deactivation of the beta catenin transactivating complex 0 36 0.0 1.0
Crosslinking of collagen fibrils 0 10 0.0 1.0
Constitutive signaling by aberrant pi3k in cancer 0 32 0.0 1.0
Pi3k akt signaling in cancer 0 58 0.0 1.0
Anchoring fibril formation 0 8 0.0 1.0
Mucopolysaccharidoses 0 9 0.0 1.0
Notch2 intracellular domain regulates transcription 0 7 0.0 1.0
Visual phototransduction 0 40 0.0 1.0
The retinoid cycle in cones daylight vision 0 1 0.0 1.0
Egfr transactivation by gastrin 0 7 0.0 1.0
Condensation of prophase chromosomes 0 23 0.0 1.0
Smad2 smad3 smad4 heterotrimer regulates transcription 0 29 0.0 1.0
Transcriptional activity of smad2 smad3 smad4 heterotrimer 0 41 0.0 1.0
Tgf beta receptor signaling in emt epithelial to mesenchymal transition 0 14 0.0 1.0
Tgf beta receptor signaling activates smads 0 28 0.0 1.0
Downregulation of tgf beta receptor signaling 0 22 0.0 1.0
Binding and uptake of ligands by scavenger receptors 1 17 6.363636363636363 0.1543818096433915
Dap12 interactions 0 21 0.0 1.0
Scavenging of heme from plasma 0 2 0.0 1.0
Synthesis of prostaglandins pg and thromboxanes tx 1 8 14.558441558441558 0.0758460972151271
Abacavir metabolism 0 4 0.0 1.0
Downregulation of smad2 3 smad4 transcriptional activity 0 23 0.0 1.0
Abacavir transport and metabolism 0 6 0.0 1.0
Phosphate bond hydrolysis by nudt proteins 0 6 0.0 1.0
Metabolism of ingested semet sec mesec into h2se 0 4 0.0 1.0
Cellular senescence 1 131 0.7743589743589744 0.7273327797177289
Senescence associated secretory phenotype sasp 0 54 0.0 1.0
Oxidative stress induced senescence 1 69 1.4896019013666073 0.4945801471111566
Mitotic metaphase and anaphase 4 225 1.8618024132730016 0.1794134798201282
Interaction with cumulus cells and the zona pellucida 0 1 0.0 1.0
The phototransduction cascade 0 12 0.0 1.0
Condensation of prometaphase chromosomes 0 11 0.0 1.0
Resolution of sister chromatid cohesion 3 120 2.6378535553793285 0.113622012200689
Activation of the phototransduction cascade 0 2 0.0 1.0
Signaling by type 1 insulin like growth factor 1 receptor igf1r 0 29 0.0 1.0
Cohesin loading onto chromatin 0 10 0.0 1.0
Separation of sister chromatids 4 179 2.362142857142857 0.098986142870204
Mastl facilitates mitotic progression 0 10 0.0 1.0
Fc epsilon receptor fceri signaling 1 108 0.9429812140092514 0.6570328218304677
The canonical retinoid cycle in rods twilight vision 0 4 0.0 1.0
Retinoid cycle disease events 0 2 0.0 1.0
Shc related events triggered by igf1r 0 7 0.0 1.0
Activation of gene expression by srebf srebp 1 42 2.477211135747721 0.339526513295544
Dap12 signaling 0 19 0.0 1.0
Selenoamino acid metabolism 3 107 2.971451229183188 0.0877302870164678
Establishment of sister chromatid cohesion 0 11 0.0 1.0
Abacavir transmembrane transport 0 2 0.0 1.0
Hyaluronan uptake and degradation 0 8 0.0 1.0
Integrin cell surface interactions 0 37 0.0 1.0
Miscellaneous substrates 0 2 0.0 1.0
Cytochrome p450 arranged by substrate type 0 15 0.0 1.0
Biological oxidations 4 94 4.632407407407407 0.0135552020851603
Gene silencing by rna 1 75 1.368004368004368 0.523802502209471
Tie2 signaling 0 12 0.0 1.0
Basigin interactions 0 16 0.0 1.0
Pecam1 interactions 0 9 0.0 1.0
Regulation of gene expression in early pancreatic precursor cells 0 3 0.0 1.0
Regulation of gene expression in beta cells 0 12 0.0 1.0
Endogenous sterols 0 12 0.0 1.0
Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells 0 10 0.0 1.0
Metabolism of amine derived hormones 0 1 0.0 1.0
Nf kb is activated and signals survival 0 11 0.0 1.0
P75ntr recruits signalling complexes 0 11 0.0 1.0
Nrif signals cell death from the nucleus 0 14 0.0 1.0
Nade modulates death signalling 0 5 0.0 1.0
Cell death signalling via nrage nrif and nade 0 63 0.0 1.0
Linoleic acid la metabolism 0 7 0.0 1.0
Alpha linolenic omega3 and linoleic omega6 acid metabolism 0 12 0.0 1.0
Regulation of pyruvate dehydrogenase pdh complex 0 16 0.0 1.0
Glutamate neurotransmitter release cycle 0 17 0.0 1.0
Eicosanoids 0 1 0.0 1.0
Xenobiotics 0 4 0.0 1.0
Cyp2e1 reactions 0 1 0.0 1.0
Activation of ppargc1a pgc 1alpha by phosphorylation 0 8 0.0 1.0
Transcriptional activation of mitochondrial biogenesis 2 51 4.184506455643482 0.0891217330395956
Hyaluronan biosynthesis and export 0 1 0.0 1.0
Hyaluronan metabolism 0 9 0.0 1.0
Synthesis of 16 20 hydroxyeicosatetraenoic acids hete 0 1 0.0 1.0
Ubiquinol biosynthesis 1 7 16.986531986531986 0.0666860823201616
Synthesis of 15 eicosatetraenoic acid derivatives 0 3 0.0 1.0
Arachidonic acid metabolism 1 18 5.98871063576946 0.1626892876910785
Synthesis of 12 eicosatetraenoic acid derivatives 0 2 0.0 1.0
Synthesis of lipoxins lx 0 1 0.0 1.0
Synthesis of leukotrienes lt and eoxins ex 0 4 0.0 1.0
Synthesis of 5 eicosatetraenoic acids 0 3 0.0 1.0
Synthesis of epoxy eet and dihydroxyeicosatrienoic acids dhet 0 1 0.0 1.0
Mhc class ii antigen presentation 2 100 2.082049146189088 0.2570757650662602
Molecules associated with elastic fibres 0 18 0.0 1.0
Egfr interacts with phospholipase c gamma 0 2 0.0 1.0
Dopamine neurotransmitter release cycle 0 18 0.0 1.0
Prc2 methylates histones and dna 1 23 4.62534435261708 0.2030300441679912
Activated notch1 transmits signal to the nucleus 0 21 0.0 1.0
Notch1 intracellular domain regulates transcription 0 39 0.0 1.0
Epigenetic regulation of gene expression 1 102 0.9995999599959996 0.6359150291554319
Formation of senescence associated heterochromatin foci sahf 0 15 0.0 1.0
Oncogene induced senescence 0 30 0.0 1.0
Dna damage telomere stress induced senescence 0 38 0.0 1.0
Trif mediated programmed cell death 1 4 33.98316498316498 0.0386632862857637
Metabolism of polyamines 1 48 2.1596819256393727 0.3776146865857887
Notch hlh transcription pathway 0 21 0.0 1.0
Hsf1 dependent transactivation 0 30 0.0 1.0
Attenuation phase 0 22 0.0 1.0
Cellular response to heat stress 1 93 1.098375054896794 0.6018020784024207
Hsf1 activation 0 25 0.0 1.0
Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand 1 47 2.206851119894598 0.3714211816154574
Regulation of hsf1 mediated heat shock response 1 76 1.3496296296296295 0.5285075461630524
Regulation by c flip 1 10 11.320987654320987 0.0938999510605359
Apoptotic cleavage of cell adhesion proteins 0 9 0.0 1.0
Defects in biotin btn metabolism 0 8 0.0 1.0
Signaling by tgf beta receptor complex in cancer 0 8 0.0 1.0
Loss of function of smad2 3 in cancer 0 7 0.0 1.0
Nuclear pore complex npc disassembly 1 36 2.903607503607504 0.299132167535026
Detoxification of reactive oxygen species 0 24 0.0 1.0
Defects in vitamin and cofactor metabolism 0 18 0.0 1.0
Defects in cobalamin b12 metabolism 0 10 0.0 1.0
Trp channels 1 7 16.986531986531986 0.0666860823201616
Irf3 mediated induction of type i ifn 0 8 0.0 1.0
Chromatin modifying enzymes 3 210 1.477513820409383 0.3396691353657701
Glycogen synthesis 0 11 0.0 1.0
Amino acid transport across the plasma membrane 0 17 0.0 1.0
Integrin signaling 0 18 0.0 1.0
Grb2 sos provides linkage to mapk signaling for integrins 0 9 0.0 1.0
Signaling by robo receptors 4 197 2.137953367875648 0.1280796806821381
Dscam interactions 0 9 0.0 1.0
Peptide ligand binding receptors 1 17 6.363636363636363 0.1543818096433915
Ncam signaling for neurite out growth 0 34 0.0 1.0
L1cam interactions 0 91 0.0 1.0
Semaphorin interactions 0 48 0.0 1.0
Nephrin family interactions 0 17 0.0 1.0
Netrin 1 signaling 0 33 0.0 1.0
Class b 2 secretin family receptors 0 25 0.0 1.0
Class a 1 rhodopsin like receptors 1 21 5.088888888888889 0.1871299927573601
Signaling by gpcr 1 204 0.4922625267452853 0.8688021526968412
P130cas linkage to mapk signaling for integrins 0 9 0.0 1.0
Transcriptional regulation by tp53 1 333 0.2970670561032006 0.9644569591737788
Defective b4galt1 causes b4galt1 cdg cdg 2d 0 1 0.0 1.0
Defective ext2 causes exostoses 2 0 11 0.0 1.0
Defective chst6 causes mcdc1 0 1 0.0 1.0
Defective chsy1 causes tpbs 0 4 0.0 1.0
Defective chst14 causes eds musculocontractural type 0 4 0.0 1.0
Defective chst3 causes sedcjd 0 4 0.0 1.0
Defective b4galt7 causes eds progeroid type 0 13 0.0 1.0
Diseases associated with glycosaminoglycan metabolism 0 26 0.0 1.0
Wnt ligand biogenesis and trafficking 0 9 0.0 1.0
Negative regulation of tcf dependent signaling by wnt ligand antagonists 0 5 0.0 1.0
Sumoylation of ubiquitinylation proteins 1 39 2.6735778841042 0.3196260593385788
Glycogen storage diseases 0 10 0.0 1.0
Peptide hormone metabolism 0 43 0.0 1.0
Notch2 activation and transmission of signal to the nucleus 0 16 0.0 1.0
Pou5f1 oct4 sox2 nanog activate genes related to proliferation 0 8 0.0 1.0
Pou5f1 oct4 sox2 nanog repress genes related to differentiation 0 6 0.0 1.0
Fceri mediated nf kb activation 1 68 1.5119855269109 0.4895400608205746
Fceri mediated ca 2 mobilization 0 20 0.0 1.0
Fceri mediated mapk activation 0 24 0.0 1.0
Role of lat2 ntal lab on calcium mobilization 0 12 0.0 1.0
Signaling by notch1 hd domain mutants in cancer 0 9 0.0 1.0
Nuclear envelope breakdown 1 54 1.9140461215932916 0.4135270958140081
Eph ephrin signaling 0 80 0.0 1.0
Signaling by notch1 t 7 9 notch1 m1580 k2555 translocation mutant 0 4 0.0 1.0
Insulin processing 0 21 0.0 1.0
Caspase mediated cleavage of cytoskeletal proteins 0 12 0.0 1.0
Acetylcholine neurotransmitter release cycle 0 11 0.0 1.0
Fbxw7 mutants and notch1 in cancer 0 5 0.0 1.0
Signaling by notch1 pest domain mutants in cancer 0 45 0.0 1.0
Signaling by leptin 0 8 0.0 1.0
Regulation of plk1 activity at g2 m transition 0 87 0.0 1.0
Cytosolic iron sulfur cluster assembly 0 13 0.0 1.0
Stimuli sensing channels 1 38 2.746109746109746 0.3128615540599918
Activation of nima kinases nek9 nek6 nek7 0 7 0.0 1.0
Sumoylation 2 155 1.326263838868881 0.4510721126516604
Initiation of nuclear envelope ne reformation 0 20 0.0 1.0
Processing and activation of sumo 0 10 0.0 1.0
Rmts methylate histone arginines 0 36 0.0 1.0
Hats acetylate histones 1 90 1.135739416638293 0.5897423730476636
Hdms demethylate histones 1 25 4.239057239057239 0.2186221342412543
Pkmts methylate histone lysines 1 46 2.2561167227833896 0.3651666660190783
Hdacs deacetylate histones 0 40 0.0 1.0
Regulation of innate immune responses to cytosolic dna 0 11 0.0 1.0
Lrr flii interacting protein 1 lrrfip1 activates type i ifn production 0 5 0.0 1.0
Dex h box helicases activate type i ifn and inflammatory cytokines production 0 7 0.0 1.0
Sumoylation of dna damage response and repair proteins 1 76 1.3496296296296295 0.5285075461630524
Sumo is proteolytically processed 0 6 0.0 1.0
Sumo is transferred from e1 to e2 ube2i ubc9 0 7 0.0 1.0
Sumo is conjugated to e1 uba2 sae1 0 5 0.0 1.0
Scavenging by class f receptors 0 5 0.0 1.0
Scavenging by class a receptors 0 10 0.0 1.0
Scavenging by class b receptors 1 2 101.96969696969695 0.0195202957776364
Ecm proteoglycans 0 37 0.0 1.0
Non integrin membrane ecm interactions 0 37 0.0 1.0
Syndecan interactions 0 20 0.0 1.0
Laminin interactions 0 23 0.0 1.0
Nuclear envelope ne reassembly 1 71 1.446753246753247 0.5045129832066302
Sumoylation of transcription factors 0 18 0.0 1.0
Activation of kainate receptors upon glutamate binding 0 16 0.0 1.0