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b8dc22f verified
Term overlap geneset_size odds pval fdr leading_edge
Eukaryotic translation elongation 14 89 7.875897435897436 2.646100314389994e-08 2.8755814313353884e-05 P05388,P42766,P46778,P46782,P62081,P62753,P62841,P62847,P62854,P62857,P62899,P62910,P84098,Q05639
Regulation of expression of slits and robos 18 155 5.604506505871152 3.6678334583359545e-08 2.8755814313353884e-05 P05388,P25787,P25789,P42766,P46778,P46782,P49720,P55036,P62081,P62753,P62841,P62847,P62854,P62857,P62899,P62910,P84098,Q9UL46
Signaling by robo receptors 19 197 4.553996369167362 3.0190569109122716e-07 0.00011834703090776106 P05388,P12931,P25787,P25789,P42766,P46778,P46782,P49720,P55036,P62081,P62753,P62841,P62847,P62854,P62857,P62899,P62910,P84098,Q9UL46
Selenoamino acid metabolism 14 107 6.3399503722084365 2.855682053752552e-07 0.00011834703090776106 P05388,P42766,P46778,P46782,P62081,P62753,P62841,P62847,P62854,P62857,P62899,P62910,P84098,Q13155
Response of eif2ak4 gcn2 to amino acid deficiency 13 94 6.738691883372734 3.985090034290397e-07 0.00012497242347534685 P05388,P42766,P46778,P46782,P62081,P62753,P62841,P62847,P62854,P62857,P62899,P62910,P84098
Srp dependent cotranslational protein targeting to membrane 13 108 5.737469204927212 2.013680729582773e-06 0.0005262418973309646 P05388,P42766,P46778,P46782,P62081,P62753,P62841,P62847,P62854,P62857,P62899,P62910,P84098
Nonsense mediated decay nmd 13 110 5.618030269796008 2.483250269116208e-06 0.0005562480602820306 P05388,P42766,P46778,P46782,P62081,P62753,P62841,P62847,P62854,P62857,P62899,P62910,P84098
Influenza infection 15 150 4.679542203147354 3.5204989980277733e-06 0.0006900178036134436 P05388,P42766,P46778,P46782,P52294,P55735,P62081,P62753,P62841,P62847,P62854,P62857,P62899,P62910,P84098
Eukaryotic translation initiation 13 116 5.287543895889279 4.527463939874227e-06 0.0007887848286358653 P05388,P42766,P46778,P46782,P62081,P62753,P62841,P62847,P62854,P62857,P62899,P62910,P84098
Infectious disease 34 619 2.54287083632878 6.283864460628401e-06 0.0009814105883892837 O15145,P04350,P05388,P07437,P12931,P25787,P25789,P39748,P42766,P46778,P46782,P49720,P52294,P55036,P55735,P62081,P62753,P62841,P62847,P62854,P62857,P62899,P62910,P62942,P63096,P63208,P84098,Q96FJ2,Q96SB4,Q99816,Q99873,Q9UL46,Q9Y2Z0,Q9Y6W5
Cellular response to starvation 14 139 4.701606837606837 6.884895709363598e-06 0.0009814105883892837 P05388,P42766,P46778,P46782,P55735,P62081,P62753,P62841,P62847,P62854,P62857,P62899,P62910,P84098
Rrna processing 17 202 3.883725283725284 8.332468493316926e-06 0.001088775883126745 O43709,P05388,P42766,P46778,P46782,P62081,P62753,P62841,P62847,P62854,P62857,P62899,P62910,P84098,Q96GA3,Q9NXG2,Q9UI30
Metabolism of rna 34 647 2.419463036087268 1.6107214803149247e-05 0.0018516264252330106 O43592,O43709,O75940,P05388,P25787,P25789,P42766,P46778,P46782,P49720,P55036,P55735,P62081,P62314,P62753,P62841,P62847,P62854,P62857,P62899,P62910,P84098,Q15365,Q15366,Q16637,Q2VPK5,Q96GA3,Q9BQA1,Q9NWZ8,Q9NXG2,Q9UBP6,Q9UI30,Q9UIV1,Q9UL46
Metabolism of amino acids and derivatives 20 281 3.2556967130469854 1.6532378796723308e-05 0.0018516264252330106 P05388,P19623,P25787,P25789,P42766,P46778,P46782,P49720,P55036,P62081,P62753,P62841,P62847,P62854,P62857,P62899,P62910,P84098,Q13155,Q9UL46
Regulation of runx2 expression and activity 8 61 6.223270440251572 0.00010576011995781506 0.011055457872923601 P11474,P25787,P25789,P49720,P55036,P63208,Q13951,Q9UL46
Synthesis of dna 11 117 4.309449884563331 0.0001261549526333197 0.011635939160532077 O43929,P25787,P25789,P35244,P35250,P39748,P49643,P49720,P55036,P63208,Q9UL46
Dna replication 12 137 3.9957966101694917 0.00012388572053079102 0.011635939160532077 O43929,P25787,P25789,P35244,P35250,P39748,P49643,P49720,P52294,P55036,P63208,Q9UL46
Mitotic g1 phase and g1 s transition 12 143 3.8104541337818607 0.00018614566140855314 0.01621535539381174 O43929,P12931,P25787,P25789,P30154,P35244,P49643,P49720,P55036,P63208,Q00534,Q9UL46
Translation 18 289 2.7945772501203274 0.00024134010034714026 0.019071870760573543 P05388,P42766,P46778,P46782,P62081,P62753,P62841,P62847,P62854,P62857,P62899,P62910,P82663,P84098,Q05639,Q13155,Q9BYD3,Q9UI30
Regulation of runx3 expression and activity 7 52 6.391977869986169 0.0002432636576603768 0.019071870760573543 P12931,P25787,P25789,P49720,P55036,Q13951,Q9UL46
Dna replication pre initiation 9 92 4.47572717648838 0.00038585091535480126 0.028810201679825162 O43929,P25787,P25789,P35244,P49643,P49720,P52294,P55036,Q9UL46
Regulation of hmox1 expression and activity 7 58 5.636563339028558 0.00048306921312023845 0.030067457860056712 P19784,P25787,P25789,P49720,P55036,P63208,Q9UL46
Cellular responses to stimuli 29 614 2.119400538578621 0.0004420899806440187 0.030067457860056712 O75935,P04350,P05388,P19784,P25787,P25789,P35244,P42766,P46778,P46782,P47755,P49720,P51858,P55036,P55735,P62081,P62753,P62841,P62847,P62854,P62857,P62899,P62910,P63208,P84098,Q00534,Q96B36,Q96FJ2,Q9UL46
Resolution of ap sites via the multiple nucleotide patch replacement pathway 5 28 8.87904813025586 0.0005082133901369885 0.030067457860056712 P27695,P35244,P35250,P39748,Q9UGN5
Cell cycle checkpoints 16 257 2.77779367577622 0.0005361707024760887 0.030067457860056712 O43929,P25787,P25789,P30154,P35244,P35250,P49720,P50748,P55036,P55735,Q92674,Q96EA4,Q96FJ2,Q9NXR7,Q9P258,Q9UL46
Nervous system development 23 443 2.318984126984127 0.0004903629293187722 0.030067457860056712 O15145,P04350,P05388,P08134,P12931,P19784,P25787,P25789,P42766,P46778,P46782,P49720,P55036,P62081,P62753,P62841,P62847,P62854,P62857,P62899,P62910,P84098,Q9UL46
Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s 7 59 5.52760932014044 0.0005369188903581555 0.030067457860056712 P46782,P62081,P62753,P62841,P62847,P62854,P62857
Separation of sister chromatids 13 179 3.259830812612151 0.00042207540158761776 0.030067457860056712 P04350,P25787,P25789,P30154,P49720,P50748,P55036,P55735,Q92674,Q96EA4,Q96FJ2,Q9P258,Q9UL46
Transcriptional regulation by runx2 9 100 4.078946158444066 0.0007140347701930095 0.038012307455808 P11474,P12931,P25787,P25789,P49720,P55036,P63208,Q13951,Q9UL46
Tp53 regulates transcription of caspase activators and caspases 3 8 24.350204081632654 0.0007272762906085714 0.038012307455808 O14727,P42575,P55212
Transcriptional regulation by runx1 11 149 3.2993946064942214 0.0010143202771897577 0.04799702538003767 P12931,P19784,P25787,P25789,P49720,P55036,Q00534,Q13951,Q99873,Q9UBL3,Q9UL46
Cell cycle mitotic 24 498 2.141500904159132 0.0010601892946036876 0.04799702538003767 O43929,O75935,P04350,P07437,P12931,P19784,P25787,P25789,P30154,P35244,P35250,P39748,P49643,P49720,P50748,P55036,P55735,P63208,Q00534,Q92674,Q96EA4,Q96FJ2,Q9P258,Q9UL46
Orc1 removal from chromatin 7 65 4.9527829446272715 0.0009684100309974315 0.04799702538003767 O43929,P25787,P25789,P49720,P55036,P63208,Q9UL46
Polb dependent long patch base excision repair 3 9 20.289795918367346 0.0010713621736615552 0.04799702538003767 P27695,P39748,Q9UGN5
Metabolism of polyamines 6 48 5.847697756788666 0.0010161722880491753 0.04799702538003767 P19623,P25787,P25789,P49720,P55036,Q9UL46
Negative regulation of notch4 signaling 6 49 5.711128195271958 0.0011347755104788061 0.04808994595758833 P25787,P25789,P49720,P55036,P63208,Q9UL46
Gene and protein expression by jak stat signaling after interleukin 12 stimulation 5 33 7.2898295120517345 0.0011115841037105713 0.04808994595758833 P05388,P14174,P78417,Q53EL6,Q9UL46
Rho gtpases activate formins 10 133 3.356220536995286 0.0014860248784806418 0.06131807919625385 P04350,P08134,P12931,P30154,P50748,P55735,Q92674,Q96EA4,Q96FJ2,Q9P258
S phase 11 158 3.094549212089899 0.0016327046062844124 0.06410782759835809 O43929,P25787,P25789,P35244,P35250,P39748,P49643,P49720,P55036,P63208,Q9UL46
Downstream signaling events of b cell receptor bcr 7 71 4.485736514522822 0.001635403765264237 0.06410782759835809 P25787,P25789,P49720,P55036,P62942,P63208,Q9UL46
Degradation of gli1 by the proteasome 6 53 5.222964656233515 0.0017183337360303884 0.0641511261451345 P25787,P25789,P49720,P55036,P63208,Q9UL46
Dectin 1 mediated noncanonical nf kb signaling 6 53 5.222964656233515 0.0017183337360303884 0.0641511261451345 P25787,P25789,P49720,P55036,P63208,Q9UL46
Scf skp2 mediated degradation of p27 p21 6 54 5.113636363636363 0.0018945002996002451 0.06751310158575419 P25787,P25789,P49720,P55036,P63208,Q9UL46
Cdt1 association with the cdc6 orc origin complex 6 54 5.113636363636363 0.0018945002996002451 0.06751310158575419 O43929,P25787,P25789,P49720,P55036,Q9UL46
Lagging strand synthesis 4 23 8.566867989646246 0.0021013452038761192 0.07260112160726195 P35244,P35250,P39748,P49643
Interleukin 12 signaling 5 38 6.182192293303404 0.002129879843070185 0.07260112160726195 P05388,P14174,P78417,Q53EL6,Q9UL46
Innate immune system 27 624 1.9136178630710112 0.0025221026459414566 0.08070728467012661 O00161,O00764,O14727,O15145,P04080,P07437,P09972,P12931,P14174,P25787,P25789,P30154,P42575,P47755,P49720,P55036,P61225,P63172,P63208,Q15366,Q6SZW1,Q9P000,Q9UBI1,Q9UL46,Q9Y2Z0,Q9Y315,Q9Y6W5
Regulation of ras by gaps 6 57 4.811375789985416 0.0025056010914147166 0.08070728467012661 P21359,P25787,P25789,P49720,P55036,Q9UL46
Pcna dependent long patch base excision repair 4 24 8.137704918032787 0.0024740226177806532 0.08070728467012661 P27695,P35244,P35250,P39748
Degradation of beta catenin by the destruction complex 7 77 4.098755186721991 0.0026150594624073827 0.08200826474109552 P25787,P25789,P30154,P49720,P55036,P63208,Q9UL46
Tnfr2 non canonical nf kb pathway 6 58 4.718372536554355 0.002738970154292758 0.08420990592021656 P25787,P25789,P49720,P55036,P63208,Q9UL46
Resolution of abasic sites ap sites 5 41 5.665294924554184 0.0029974307870657747 0.08703650877998398 P27695,P35244,P35250,P39748,Q9UGN5
Cross presentation of soluble exogenous antigens endosomes 5 41 5.665294924554184 0.0029974307870657747 0.08703650877998398 P25787,P25789,P49720,P55036,Q9UL46
Signaling by interleukins 14 248 2.4836730221345604 0.002952486268776042 0.08703650877998398 P05388,P14174,P25787,P25789,P30154,P40222,P46109,P49720,P55036,P63208,P78417,Q07820,Q53EL6,Q9UL46
Transport to the golgi and subsequent modification 10 148 2.9868469126781148 0.0032689790940695273 0.09319562217274581 O15027,O15155,O75935,P04350,P33908,P47755,P55735,P84085,Q96FJ2,Q96JB2
Mitotic metaphase and anaphase 13 225 2.5405058209554396 0.0033826539396570243 0.09471431031039669 P04350,P25787,P25789,P30154,P49720,P50748,P55036,P55735,Q92674,Q96EA4,Q96FJ2,Q9P258,Q9UL46
Interleukin 12 family signaling 5 43 5.366038553173056 0.0037016693244557508 0.10089893781640008 P05388,P14174,P78417,Q53EL6,Q9UL46
Metabolism of nucleotides 7 82 3.8235684647302906 0.0037322311182086763 0.10089893781640008 O43598,O76075,P32321,P49915,Q96DE0,Q9H773,Q9Y3D8
Er to golgi anterograde transport 9 129 3.084100418410042 0.004190831809866437 0.10952040463117621 O15027,O15155,O75935,P04350,P47755,P55735,P84085,Q96FJ2,Q96JB2
Regulation of pten stability and activity 6 63 4.30230535015224 0.004157885227663474 0.10952040463117621 P19784,P25787,P25789,P49720,P55036,Q9UL46
Switching of origins to a post replicative state 7 85 3.675390999042451 0.0045575961472511025 0.11526307675628594 O43929,P25787,P25789,P49720,P55036,P63208,Q9UL46
Clec7a dectin 1 signaling 7 85 3.675390999042451 0.0045575961472511025 0.11526307675628594 P12931,P25787,P25789,P49720,P55036,P63208,Q9UL46
Transcriptional regulation by runx3 7 86 3.6284993959766796 0.004861205181450997 0.1209899956272248 P12931,P25787,P25789,P49720,P55036,Q13951,Q9UL46
Selective autophagy 6 67 4.0185611705730935 0.00563573417688316 0.12995339984342347 P04350,P12931,P19784,Q8IWA4,Q96FJ2,Q99497
Apoptosis 10 159 2.7632395239975183 0.005430882665337735 0.12995339984342347 O14727,O76075,P25787,P25789,P49720,P52294,P55036,P55212,Q96FJ2,Q9UL46
The role of gtse1 in g2 m progression after g2 checkpoint 6 67 4.0185611705730935 0.00563573417688316 0.12995339984342347 P04350,P25787,P25789,P49720,P55036,Q9UL46
G2 m checkpoints 9 134 2.9592301255230127 0.00537501283119236 0.12995339984342347 O43929,P25787,P25789,P35244,P35250,P49720,P55036,Q9NXR7,Q9UL46
Neddylation 11 185 2.607158446093409 0.005511680492572273 0.12995339984342347 P25787,P25789,P49720,P55036,P63208,Q96GG9,Q9BW61,Q9NXF7,Q9P000,Q9UBI1,Q9UL46
Fceri mediated nf kb activation 6 68 3.953345774460144 0.006058429580529335 0.13013174770232872 P25787,P25789,P49720,P55036,P63208,Q9UL46
Copi mediated anterograde transport 7 89 3.494686772593867 0.005863782483627969 0.13013174770232872 O15155,O75935,P04350,P47755,P84085,Q96FJ2,Q96JB2
Auf1 hnrnp d0 binds and destabilizes mrna 5 48 4.739688008421859 0.005969199042531204 0.13013174770232872 P25787,P25789,P49720,P55036,Q9UL46
Degradation of axin 5 48 4.739688008421859 0.005969199042531204 0.13013174770232872 P25787,P25789,P49720,P55036,Q9UL46
Runx1 regulates transcription of genes involved in differentiation of hscs 6 68 3.953345774460144 0.006058429580529335 0.13013174770232872 P25787,P25789,P49720,P55036,Q13951,Q9UL46
Signaling by the b cell receptor bcr 7 91 3.4107883817427385 0.006613158048954163 0.14012745703729904 P25787,P25789,P49720,P55036,P62942,P63208,Q9UL46
Regulation of runx1 expression and activity 3 17 8.688629737609329 0.007510539548381692 0.14361617087637185 P12931,Q00534,Q13951
Signaling by notch4 6 71 3.7697393515575333 0.007465079221721309 0.14361617087637185 P25787,P25789,P49720,P55036,P63208,Q9UL46
Processive synthesis on the lagging strand 3 17 8.688629737609329 0.007510539548381692 0.14361617087637185 P35244,P39748,P49643
Degradation of dvl 5 50 4.528120713305898 0.007102438578776749 0.14361617087637185 P25787,P25789,P49720,P55036,Q9UL46
Asparagine n linked glycosylation 13 245 2.3167278063096113 0.006879147584651534 0.14361617087637185 O15027,O15155,O60547,O75935,P04350,P33908,P47755,P55735,P84085,Q86YN1,Q96EK6,Q96FJ2,Q96JB2
Diseases of signal transduction by growth factor receptors and second messengers 16 333 2.0952898944849343 0.007345493896563287 0.14361617087637185 P12931,P21359,P25787,P25789,P30086,P30154,P49720,P55036,P62753,P62942,P63208,Q86WB0,Q96B36,Q99956,Q9NRY5,Q9UL46
Nuclear events stimulated by alk signaling in cancer 3 17 8.688629737609329 0.007510539548381692 0.14361617087637185 P62753,P63208,Q86WB0
Host interactions of hiv factors 8 116 3.037037037037037 0.00727806256813064 0.14361617087637185 P25787,P25789,P49720,P52294,P55036,P55735,P63208,Q9UL46
Cell cycle 25 613 1.7845703303743021 0.0076407932168108044 0.1441418242077159 O43929,O75935,P04350,P07437,P12931,P19784,P25787,P25789,P30154,P35244,P35250,P39748,P49643,P49720,P50748,P55036,P55735,P63208,Q00534,Q92674,Q96EA4,Q96FJ2,Q9NXR7,Q9P258,Q9UL46
Stabilization of p53 5 51 4.429235999284309 0.007721883439699066 0.1441418242077159 P25787,P25789,P49720,P55036,Q9UL46
Hedgehog ligand biogenesis 5 53 4.243827160493828 0.009071656592741978 0.15982424199347664 P25787,P25789,P49720,P55036,Q9UL46
Mitotic prometaphase 11 198 2.4226855299081658 0.00902404818998548 0.15982424199347664 O75935,P04350,P07437,P19784,P30154,P50748,P55735,Q92674,Q96EA4,Q96FJ2,Q9P258
Hedgehog off state 7 96 3.2175392792204764 0.008796622568215947 0.15982424199347664 P04350,P25787,P25789,P49720,P55036,P63208,Q9UL46
Resolution of sister chromatid cohesion 8 120 2.927380952380952 0.008865043822244687 0.15982424199347664 P04350,P30154,P50748,P55735,Q92674,Q96EA4,Q96FJ2,Q9P258
Snrnp assembly 5 53 4.243827160493828 0.009071656592741978 0.15982424199347664 P55735,P62314,Q16637,Q9BQA1,Q9NWZ8
Asymmetric localization of pcp proteins 5 54 4.156798521877887 0.009804019480028514 0.16866475592330307 P25787,P25789,P49720,P55036,Q9UL46
Defective cftr causes cystic fibrosis 5 54 4.156798521877887 0.009804019480028514 0.16866475592330307 P25787,P25789,P49720,P55036,Q9UL46
Dna strand elongation 4 35 5.244315177154944 0.009896146393459109 0.16866475592330307 P35244,P35250,P39748,P49643
Membrane trafficking 22 532 1.8014575741801144 0.01037471446424415 0.17491991698854653 O00161,O00471,O15027,O15145,O15155,O60645,O75935,P04350,P12931,P33908,P47755,P52594,P55735,P62330,P84085,Q13492,Q15642,Q96FJ2,Q96JB2,Q99816,Q9BZE9,Q9NVG8
Base excision repair 5 55 4.073251028806585 0.010576020370686329 0.17641702065144857 P27695,P35244,P35250,P39748,Q9UGN5
C type lectin receptors clrs 7 100 3.0779012180431 0.010892237016375785 0.17855708848948082 P12931,P25787,P25789,P49720,P55036,P63208,Q9UL46
Developmental biology 26 665 1.7061709596920864 0.01104594233640283 0.17855708848948082 O15145,P04350,P05388,P08134,P12931,P19784,P24468,P25787,P25789,P42766,P46778,P46782,P49720,P55036,P62081,P62753,P62841,P62847,P62854,P62857,P62899,P62910,P84098,Q13951,Q9UBL3,Q9UL46
Antigen processing cross presentation 6 77 3.4490746129670584 0.010961681065377378 0.17855708848948082 O00161,P25787,P25789,P49720,P55036,Q9UL46
Programmed cell death 10 179 2.431256526279151 0.012071052663454146 0.19118596541713237 O14727,O76075,P25787,P25789,P49720,P52294,P55036,P55212,Q96FJ2,Q9UL46
Telomere c strand lagging strand synthesis 4 37 4.92548435171386 0.012020755015892202 0.19118596541713237 P35244,P35250,P39748,P49643
Cyclin a cdk2 associated events at s phase entry 6 79 3.353900147175365 0.012348666654089319 0.19170999320407972 P25787,P25789,P49720,P55036,P63208,Q9UL46
Uch proteinases 6 79 3.353900147175365 0.012348666654089319 0.19170999320407972 P25787,P25789,P49720,P55036,P85037,Q9UL46
M phase 16 355 1.9548367409215746 0.013045617976136868 0.20054440182924127 O75935,P04350,P07437,P19784,P25787,P25789,P30154,P49720,P50748,P55036,P55735,Q92674,Q96EA4,Q96FJ2,Q9P258,Q9UL46
Vesicle mediated transport 22 546 1.7507262041478078 0.013719853534945557 0.20826672798530865 O00161,O00471,O15027,O15145,O15155,O60645,O75935,P04350,P12931,P33908,P47755,P52594,P55735,P62330,P84085,Q13492,Q15642,Q96FJ2,Q96JB2,Q99816,Q9BZE9,Q9NVG8
Autophagy 8 130 2.6846994535519126 0.013953529609069181 0.20826672798530865 P04350,P12931,P19784,Q8IWA4,Q96FJ2,Q99497,Q99816,Q9Y4P1
Apc c mediated degradation of cell cycle proteins 6 81 3.263801652892562 0.013854686140062408 0.20826672798530865 P25787,P25789,P49720,P55036,P63208,Q9UL46
Cellular response to hypoxia 5 59 3.770004572473708 0.014079255845945611 0.20826672798530865 P25787,P25789,P49720,P55036,Q9UL46
Interleukin 1 signaling 6 82 3.2205306655067423 0.014653827326174238 0.21474019857421686 P25787,P25789,P49720,P55036,P63208,Q9UL46
Cytokine signaling in immune system 17 392 1.8786839826839827 0.015132637943309787 0.21970348421397914 P05388,P14174,P25787,P25789,P30154,P40222,P46109,P49720,P52294,P55036,P55735,P63208,P78417,Q07820,Q13325,Q53EL6,Q9UL46
Mitotic g2 g2 m phases 10 186 2.3328877005347595 0.015456951607588414 0.22235321211650122 O75935,P04350,P07437,P25787,P25789,P30154,P49720,P55036,P63208,Q9UL46
Abc transporter disorders 5 61 3.634626690182246 0.016092475953857065 0.22732434500583673 P25787,P25789,P49720,P55036,Q9UL46
G1 s dna damage checkpoints 5 61 3.634626690182246 0.016092475953857065 0.22732434500583673 P25787,P25789,P49720,P55036,Q9UL46
E2f mediated regulation of dna replication 3 23 6.078367346938776 0.01757582410553357 0.23903980863673643 O43929,P30154,P49643
Rho gtpase effectors 12 246 2.1108213820078228 0.01709677941693948 0.23903980863673643 O15145,P04350,P08134,P12931,P30154,P50748,P55735,Q92674,Q96EA4,Q96FJ2,Q9P258,Q9Y6W5
Mtorc1 mediated signalling 3 23 6.078367346938776 0.01757582410553357 0.23903980863673643 P62753,P62942,Q96B36
Tcr signaling 6 85 3.0972905115597866 0.01724268269283395 0.23903980863673643 P25787,P25789,P49720,P55036,P63208,Q9UL46
Cytoprotection by hmox1 7 110 2.77625589171333 0.01768406747567693 0.23903980863673643 P19784,P25787,P25789,P49720,P55036,P63208,Q9UL46
Rrna modification in the nucleus and cytosol 5 63 3.5085852135660565 0.01828891673172541 0.24510274731064483 O43709,P62081,P62753,Q9NXG2,Q9UI30
Mitotic spindle checkpoint 7 111 2.7492818384934568 0.018496909270331974 0.24578943843966555 P30154,P50748,P55735,Q92674,Q96EA4,Q96FJ2,Q9P258
Mitophagy 3 24 5.788338192419825 0.01973322431902656 0.2600142498507029 P12931,P19784,Q8IWA4
Oncogenic mapk signaling 5 66 3.3350199015044186 0.021940129979780967 0.28431507279583934 P12931,P21359,P30086,Q99956,Q9NRY5
Translocation of slc2a4 glut4 to the plasma membrane 5 66 3.3350199015044186 0.021940129979780967 0.28431507279583934 O00161,O00471,O60645,P04350,Q9BZE9
Tcf dependent signaling in response to wnt 8 142 2.4412935323383085 0.022542870668430352 0.28973132137785895 P19784,P25787,P25789,P30154,P49720,P55036,Q9UBL3,Q9UL46
Cyclin d associated events in g1 4 45 3.9612155137944822 0.023337681715212607 0.2904244835670902 P12931,P30154,P63208,Q00534
Met receptor recycling 2 10 10.101626016260163 0.023312520520495414 0.2904244835670902 P46109,P62330
Copi independent golgi to er retrograde traffic 4 45 3.9612155137944822 0.023337681715212607 0.2904244835670902 O75935,P04350,P47755,Q96FJ2
Receptor mediated mitophagy 2 10 10.101626016260163 0.023312520520495414 0.2904244835670902 P12931,P19784
Interconversion of nucleotide di and triphosphates 3 26 5.28393966282165 0.024466494280001184 0.30159264596522317 P32321,Q9H773,Q9Y3D8
Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 5 68 3.228493043307858 0.024619807833895765 0.30159264596522317 P25787,P25789,P49720,P55036,Q9UL46
Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand 4 47 3.7762104460541366 0.026913414377945487 0.32713359491952343 O75935,P04350,P47755,Q96FJ2
Interleukin 1 family signaling 6 95 2.7464945677407373 0.028105003735856067 0.33134320193851363 P25787,P25789,P49720,P55036,P63208,Q9UL46
Hedgehog on state 5 70 3.12852168407724 0.027501484207333754 0.33134320193851363 P25787,P25789,P49720,P55036,Q9UL46
Hdr through mmej alt nhej 2 11 8.978319783197833 0.028042006643782647 0.33134320193851363 P39748,Q9UGN5
Apoptosis induced dna fragmentation 2 11 8.978319783197833 0.028042006643782647 0.33134320193851363 O76075,P52294
Post translational protein modification 34 1003 1.472208558780128 0.028785849970277232 0.33683740860742317 O15027,O15155,O60547,O60678,O75935,P04350,P25787,P25789,P33908,P47755,P49720,P54578,P55036,P55735,P63208,P84085,P85037,Q14527,Q86YN1,Q96EK6,Q96FJ2,Q96FW1,Q96GG9,Q96JB2,Q96RU2,Q99497,Q9BW61,Q9BZG1,Q9H2P9,Q9NXF7,Q9NXR7,Q9P000,Q9UBI1,Q9UL46
Signaling by hedgehog 7 122 2.4835287750315715 0.029228942971082632 0.3394887598419079 P04350,P25787,P25789,P49720,P55036,P63208,Q9UL46
Ub specific processing proteases 8 151 2.2855477855477857 0.03105513535636682 0.35804744293222923 P25787,P25789,P49720,P54578,P55036,Q96FW1,Q96RU2,Q9UL46
Methylation 2 12 8.079674796747968 0.03311878610765894 0.3790529680059067 P78417,Q9UI30
Mapk family signaling cascades 10 212 2.0272069223729097 0.034349263587287474 0.39028728481787506 P12931,P21359,P25787,P25789,P30086,P30154,P49720,P55036,Q99956,Q9UL46
Recognition of dna damage by pcna containing replication complex 3 30 4.499319727891156 0.03560143363730739 0.39327380253402866 O94782,P35244,P35250
Hiv infection 10 213 2.017013702032537 0.03530256605067876 0.39327380253402866 P25787,P25789,P39748,P49720,P52294,P55036,P55735,P63208,Q99816,Q9UL46
Abc family proteins mediated transport 5 75 2.903586125808348 0.03561535711723984 0.39327380253402866 P25787,P25789,P49720,P55036,Q9UL46
Signaling by wnt 10 213 2.017013702032537 0.03530256605067876 0.39327380253402866 P19784,P25787,P25789,P30154,P49720,P55036,P63208,Q01970,Q9UBL3,Q9UL46
Extension of telomeres 4 52 3.3811475409836067 0.037218074889091554 0.40809749249017874 P35244,P35250,P39748,P49643
Early phase of hiv life cycle 2 13 7.344419807834442 0.03852331024249581 0.41372979767283175 P39748,P52294
Inhibition of replication initiation of damaged dna by rb1 e2f1 2 13 7.344419807834442 0.03852331024249581 0.41372979767283175 P30154,P49643
Maturation of sars cov 2 nucleoprotein 2 13 7.344419807834442 0.03852331024249581 0.41372979767283175 Q96SB4,Q99873
Mapk6 mapk4 signaling 5 77 2.8223593964334706 0.039233142510192984 0.4184868534420585 P25787,P25789,P49720,P55036,Q9UL46
Phase ii conjugation of compounds 4 53 3.311809969889595 0.03951574168909833 0.41865326330071745 P21266,P78417,Q96IU4,Q9UI30
Pcp ce pathway 5 78 2.783415074130447 0.04112304278698969 0.4327579267785223 P25787,P25789,P49720,P55036,Q9UL46
Deubiquitination 10 221 1.9389461945915807 0.04360063610511719 0.4497749829791037 P25787,P25789,P49720,P54578,P55036,P85037,Q96FW1,Q96RU2,Q9NXR7,Q9UL46
Regulation of mrna stability by proteins that bind au rich elements 5 79 2.7455233010788564 0.043067257390812186 0.4497749829791037 P25787,P25789,P49720,P55036,Q9UL46
Cellular response to chemical stress 7 133 2.26417704011065 0.04354200015602218 0.4497749829791037 P19784,P25787,P25789,P49720,P55036,P63208,Q9UL46
Purine catabolism 2 14 6.7317073170731705 0.044236769212703655 0.45335460212757733 O43598,Q96DE0
Activation of the pre replicative complex 3 33 4.048163265306123 0.04538691275312831 0.46212129348639736 O43929,P35244,P49643
Neutrophil degranulation 13 319 1.743095536086775 0.04790565357658834 0.48152823121697447 O00161,O00764,O14727,P04080,P07437,P09972,P14174,P25787,P61225,P63172,Q9P000,Q9UBI1,Q9Y315
Fc epsilon receptor fceri signaling 6 108 2.3932912007778318 0.047907145452709195 0.48152823121697447 P25787,P25789,P49720,P55036,P63208,Q9UL46
Tp53 regulates transcription of cell death genes 3 34 3.917182356813693 0.04891478926556611 0.48543284536966874 O14727,P42575,P55212
Aggrephagy 3 34 3.917182356813693 0.04891478926556611 0.48543284536966874 P04350,Q96FJ2,Q99497
Dna double strand break repair 7 137 2.19361634216406 0.04970139898125554 0.49013706668307355 O95551,P35244,P35250,P39748,Q99504,Q9NXR7,Q9UGN5
Nucleotide biosynthesis 2 16 5.768873403019745 0.05651880236367153 0.5436900742713924 O76075,P49915
Polymerase switching 2 16 5.768873403019745 0.05651880236367153 0.5436900742713924 P35250,P49643
Rmts methylate histone arginines 3 36 3.679035250463822 0.056358935217858286 0.5436900742713924 O60678,Q99873,Q9BQA1
Negative regulation of mapk pathway 3 36 3.679035250463822 0.056358935217858286 0.5436900742713924 P30086,P30154,Q99956
Disorders of transmembrane transporters 6 115 2.238001364773675 0.06142562901229055 0.5872889408004365 P25787,P25789,P49720,P55036,P55735,Q9UL46
G alpha i signalling events 5 88 2.4455848083692797 0.0630291690616586 0.5920208158829277 P12931,P30154,P63096,Q01970,Q9NRV9
Translesion synthesis by polk 2 17 5.383739837398374 0.06305323740589855 0.5920208158829277 P35244,P35250
Ctla4 inhibitory signaling 2 17 5.383739837398374 0.06305323740589855 0.5920208158829277 P12931,P30154
Activation of atr in response to replication stress 3 38 3.468104956268222 0.06430713389124804 0.600199916318315 O43929,P35244,P35250
Beta catenin independent wnt signaling 6 117 2.1972302881393793 0.06566403868623759 0.6081897148724942 P25787,P25789,P49720,P55036,Q01970,Q9UL46
Adaptive immune system 18 504 1.5236714975845411 0.06593893592367603 0.6081897148724942 O00161,O75935,P04350,P12931,P25787,P25789,P30154,P47755,P49720,P55036,P55735,P62942,P63208,Q15386,Q7Z6J8,Q8TDB6,Q96FJ2,Q9UL46
Mtor signalling 3 39 3.3714285714285714 0.06846461064235947 0.6241424970187188 P62753,P62942,Q96B36
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function 3 39 3.3714285714285714 0.06846461064235947 0.6241424970187188 Q13951,Q99873,Q9UBL3
Runx1 and foxp3 control the development of regulatory t lymphocytes tregs 1 3 20.133603238866396 0.07121613260934825 0.6273421119744835 Q13951
Formyl peptide receptors bind formyl peptides and many other ligands 1 3 20.133603238866396 0.07121613260934825 0.6273421119744835 Q9NRV9
Post chaperonin tubulin folding pathway 2 18 5.046747967479675 0.0698282842903305 0.6273421119744835 P04350,Q99426
Runx1 regulates transcription of genes involved in wnt signaling 1 3 20.133603238866396 0.07121613260934825 0.6273421119744835 Q13951
Runx2 regulates chondrocyte maturation 1 3 20.133603238866396 0.07121613260934825 0.6273421119744835 Q13951
Vxpx cargo targeting to cilium 2 18 5.046747967479675 0.0698282842903305 0.6273421119744835 O00471,O60645
Sensory processing of sound 3 40 3.2799779371207944 0.07274111139895809 0.6371958808579122 P23634,P47755,Q14651
Glycolysis 4 66 2.613960867265997 0.07652881635181466 0.6666510224424743 A6NDG6,P09972,P30154,P55735
Signaling by notch 7 152 1.9636857919587924 0.07754299417009727 0.6717536732525554 P25787,P25789,P49720,P55036,P63208,Q9H488,Q9UL46
Cilium assembly 8 183 1.8615238095238096 0.07825905992899473 0.6742319009267238 O00471,O60645,O75935,P04350,P07437,Q8IW35,Q96FJ2,Q9Y547
Dual incision in gg ner 3 42 3.1111459968602824 0.08164094241174515 0.6995245776044612 P35244,P35250,Q9UGN5
Assembly of the orc complex at the origin of replication 2 20 4.485094850948509 0.08403896417099337 0.7084575044092344 O43929,P52294
Runx2 regulates osteoblast differentiation 2 20 4.485094850948509 0.08403896417099337 0.7084575044092344 P12931,Q13951
Translesion synthesis by polh 2 20 4.485094850948509 0.08403896417099337 0.7084575044092344 P35244,P35250
Trna modification in the nucleus and cytosol 3 43 3.033061224489796 0.0862589503665335 0.7232836052124306 Q2VPK5,Q9UBP6,Q9UI30
Processive synthesis on the c strand of the telomere 2 21 4.248609328198545 0.09144546372743352 0.7318412743810456 P35244,P39748
Runx1 regulates transcription of genes involved in interleukin signaling 1 4 13.421052631578947 0.09381383683073352 0.7318412743810456 Q13951
Activated ntrk2 signals through fyn 1 4 13.421052631578947 0.09381383683073352 0.7318412743810456 P12931
Synthesis of substrates in n glycan biosythesis 3 44 2.9587854654056747 0.09098535486842217 0.7318412743810456 O60547,Q86YN1,Q96EK6
Runx1 regulates transcription of genes involved in differentiation of keratinocytes 1 4 13.421052631578947 0.09381383683073352 0.7318412743810456 Q13951
Activated ntrk3 signals through pi3k 1 4 13.421052631578947 0.09381383683073352 0.7318412743810456 P12931
Insulin processing 2 21 4.248609328198545 0.09144546372743352 0.7318412743810456 O00471,O60645
Pten regulation 6 128 1.9968838910716704 0.09195361218745295 0.7318412743810456 P19784,P25787,P25789,P49720,P55036,Q9UL46
Runx1 regulates transcription of genes involved in bcr signaling 1 4 13.421052631578947 0.09381383683073352 0.7318412743810456 Q13951
Runx1 regulates expression of components of tight junctions 1 4 13.421052631578947 0.09381383683073352 0.7318412743810456 Q13951
N glycan trimming and elongation in the cis golgi 1 4 13.421052631578947 0.09381383683073352 0.7318412743810456 P33908
Signaling by mapk mutants 1 4 13.421052631578947 0.09381383683073352 0.7318412743810456 Q99956
Runx3 regulates immune response and cell migration 1 4 13.421052631578947 0.09381383683073352 0.7318412743810456 Q13951
Glutathione conjugation 2 21 4.248609328198545 0.09144546372743352 0.7318412743810456 P21266,P78417
Chromosome maintenance 5 100 2.1340697422568766 0.09648173552664858 0.7452382330334235 P35244,P35250,P39748,P49643,Q92674
Mhc class ii antigen presentation 5 100 2.1340697422568766 0.09648173552664858 0.7452382330334235 O75935,P04350,P47755,P55735,Q96FJ2
Signal amplification 2 22 4.035772357723578 0.09903426871785652 0.7574913821931659 P12931,P63096
Nucleotide catabolism 2 22 4.035772357723578 0.09903426871785652 0.7574913821931659 O43598,Q96DE0
Telomere maintenance 4 74 2.3133489461358314 0.10558869401174853 0.79365148169805 P35244,P35250,P39748,P49643
Apoptotic execution phase 3 47 2.7562152133580704 0.10578645387429365 0.79365148169805 O76075,P52294,P55212
Extra nuclear estrogen signaling 3 47 2.7562152133580704 0.10578645387429365 0.79365148169805 P12931,P63096,Q99873
Class i mhc mediated antigen processing presentation 11 295 1.5793664943245973 0.10560039368039786 0.79365148169805 O00161,P25787,P25789,P49720,P55036,P55735,P63208,Q15386,Q7Z6J8,Q8TDB6,Q9UL46
Downstream signal transduction 2 23 3.843205574912892 0.10679221582361295 0.7973818781496433 P12931,P46109
Nade modulates death signalling 1 5 10.064777327935223 0.11586389260545485 0.8058050497461382 P42575
Runx1 regulates transcription of genes involved in differentiation of myeloid cells 1 5 10.064777327935223 0.11586389260545485 0.8058050497461382 Q13951
Homology directed repair 5 106 2.0060709774681174 0.11600356277278351 0.8058050497461382 P35244,P35250,P39748,Q9NXR7,Q9UGN5
Runx2 regulates genes involved in cell migration 1 5 10.064777327935223 0.11586389260545485 0.8058050497461382 Q13951
Dna damage bypass 3 49 2.6358473824312334 0.11614281967004289 0.8058050497461382 O94782,P35244,P35250
Netrin mediated repulsion signals 1 5 10.064777327935223 0.11586389260545485 0.8058050497461382 P12931
Runx1 regulates estrogen receptor mediated transcription 1 5 10.064777327935223 0.11586389260545485 0.8058050497461382 Q13951
Pre notch processing in the endoplasmic reticulum 1 5 10.064777327935223 0.11586389260545485 0.8058050497461382 Q9H488
Fcgr activation 1 5 10.064777327935223 0.11586389260545485 0.8058050497461382 P12931
Intraflagellar transport 3 48 2.6946938775510203 0.11091772187118938 0.8058050497461382 P04350,Q96FJ2,Q9Y547
Fbxw7 mutants and notch1 in cancer 1 5 10.064777327935223 0.11586389260545485 0.8058050497461382 P63208
Synthesis of dolichyl phosphate 1 5 10.064777327935223 0.11586389260545485 0.8058050497461382 Q86YN1
Intracellular signaling by second messengers 9 233 1.6347130902570233 0.11526909388213238 0.8058050497461382 P12931,P19784,P25787,P25789,P30154,P49720,P55036,Q96B36,Q9UL46
Synthesis of pips at the er membrane 1 5 10.064777327935223 0.11586389260545485 0.8058050497461382 Q13614
Cholesterol biosynthesis 2 24 3.6681448632668143 0.1147066696002357 0.8058050497461382 Q03426,Q15392
Ras signaling downstream of nf1 loss of function variants 1 5 10.064777327935223 0.11586389260545485 0.8058050497461382 P21359
Parasite infection 3 50 2.5795049934867564 0.12145873319412429 0.8389748618871669 O15145,P12931,Q9Y6W5
Sensory processing of sound by outer hair cells of the cochlea 2 25 3.508306822198657 0.12276550474687985 0.8442820677329281 P23634,Q14651
Trna processing 5 109 1.9476100031655588 0.12641862258185002 0.861845218297134 O43592,P55735,Q2VPK5,Q9UBP6,Q9UI30
Protein folding 4 79 2.158032786885246 0.12594030791982394 0.861845218297134 P04350,P19784,P61758,Q99426
Leishmania infection 5 110 1.9288653733098178 0.12998325067828345 0.8799511360727755 O15145,P12931,P63096,Q9Y2Z0,Q9Y6W5
Glucose metabolism 4 80 2.1294219154443486 0.13019685176586984 0.8799511360727755 A6NDG6,P09972,P30154,P55735
Runx2 regulates bone development 2 26 3.361788617886179 0.1309570889500886 0.8812906243508108 P12931,Q13951
Signaling by alk in cancer 3 52 2.4737192836318203 0.1323508586296182 0.886863873210433 P62753,P63208,Q86WB0
Gdp fucose biosynthesis 1 6 8.051012145748988 0.13737951958985986 0.8936366699570208 O60547
Activation of caspases through apoptosome mediated cleavage 1 6 8.051012145748988 0.13737951958985986 0.8936366699570208 O14727
Signaling by braf and raf1 fusions 3 53 2.424 0.13792096564387693 0.8936366699570208 P12931,P30086,Q9NRY5
Vitamin c ascorbate metabolism 1 6 8.051012145748988 0.13737951958985986 0.8936366699570208 P78417
Pp2a mediated dephosphorylation of key metabolic factors 1 6 8.051012145748988 0.13737951958985986 0.8936366699570208 P30154
Adenylate cyclase inhibitory pathway 1 6 8.051012145748988 0.13737951958985986 0.8936366699570208 P63096
Phosphate bond hydrolysis by nudt proteins 1 6 8.051012145748988 0.13737951958985986 0.8936366699570208 Q96DE0
Fatty acids bound to gpr40 ffar1 regulate insulin secretion 1 6 8.051012145748988 0.13737951958985986 0.8936366699570208 Q01970
Gap junction trafficking and regulation 2 28 3.1025641025641026 0.1476943407876319 0.9414013266463693 P04350,P12931
Gap filling dna repair synthesis and ligation in gg ner 2 28 3.1025641025641026 0.1476943407876319 0.9414013266463693 P35244,P35250
Cooperation of prefoldin and tric cct in actin and tubulin folding 2 28 3.1025641025641026 0.1476943407876319 0.9414013266463693 P04350,P61758
Polymerase switching on the c strand of the telomere 2 28 3.1025641025641026 0.1476943407876319 0.9414013266463693 P35250,P49643
Golgi to er retrograde transport 5 115 1.8402543958099513 0.14847355637013598 0.9425365845683127 O75935,P04350,P47755,P84085,Q96FJ2
Copii mediated vesicle transport 3 55 2.330298273155416 0.1492939653041362 0.9439231354713127 O15027,O15155,P55735
Reduction of cytosolic ca levels 1 7 6.708502024291498 0.15837361960749743 0.9514553085998313 P23634
Gp1b ix v activation signalling 1 7 6.708502024291498 0.15837361960749743 0.9514553085998313 P12931
Ubiquinol biosynthesis 1 7 6.708502024291498 0.15837361960749743 0.9514553085998313 Q5T2R2
Met promotes cell motility 2 29 2.987353206865402 0.15621906140453523 0.9514553085998313 P12931,P46109
Nuclear receptor transcription pathway 2 29 2.987353206865402 0.15621906140453523 0.9514553085998313 P11474,Q9UHY1
Molybdenum cofactor biosynthesis 1 7 6.708502024291498 0.15837361960749743 0.9514553085998313 Q96EN8
Regulation of commissural axon pathfinding by slit and robo 1 7 6.708502024291498 0.15837361960749743 0.9514553085998313 P12931
Antigen processing ubiquitination proteasome degradation 9 250 1.5167450823799025 0.1561261896895651 0.9514553085998313 P25787,P25789,P49720,P55036,P63208,Q15386,Q7Z6J8,Q8TDB6,Q9UL46
Downregulation of erbb4 signaling 1 7 6.708502024291498 0.15837361960749743 0.9514553085998313 P12931
Late endosomal microautophagy 2 29 2.987353206865402 0.15621906140453523 0.9514553085998313 Q99497,Q99816
Ketone body metabolism 1 7 6.708502024291498 0.15837361960749743 0.9514553085998313 P55809
Intra golgi and retrograde golgi to er traffic 7 181 1.6315638861067392 0.1524051912460338 0.9514553085998313 O75935,P04350,P33908,P47755,P84085,Q96FJ2,Q96JB2
Regulation of cytoskeletal remodeling and cell spreading by ipp complex components 1 7 6.708502024291498 0.15837361960749743 0.9514553085998313 Q15404
Regulation of plk1 activity at g2 m transition 4 87 1.9484495358483114 0.16157573586647628 0.9669876100711252 O75935,P04350,P07437,P63208
Clathrin mediated endocytosis 5 119 1.7749620965995234 0.16402347191883548 0.9779041975997492 O15145,P52594,P62330,Q13492,Q15642
Signalling to erks 2 30 2.8803716608594656 0.16483460624335294 0.9790176613241569 P12931,P46109
Rna polymerase iii transcription termination 0 24 0.0 1.0 1.0
Purine salvage 0 12 0.0 1.0 1.0
Purine ribonucleoside monophosphate biosynthesis 1 11 4.0234817813765185 0.2373820829012167 1.0 P49915
Rna polymerase iii chain elongation 0 19 0.0 1.0 1.0
Dna replication initiation 1 8 5.749566223250434 0.17885878423025256 1.0 P49643
Trafficking of myristoylated proteins to the cilium 0 4 0.0 1.0 1.0
Rna polymerase i promoter escape 0 42 0.0 1.0 1.0
Anchoring of the basal body to the plasma membrane 4 95 1.775716087191497 0.20039143670692988 1.0 O75935,P04350,P07437,Q8IW35
Rna polymerase i transcription initiation 0 49 0.0 1.0 1.0
Activation of anterior hox genes in hindbrain development during early embryogenesis 1 60 0.6785836821519248 0.7727677095034151 1.0 Q9UBL3
Pyrimidine catabolism 0 6 0.0 1.0 1.0
Mismatch repair 1 17 2.513157894736842 0.3422564852890665 1.0 P35244
Cdc6 association with the orc origin complex 1 12 3.6573426573426575 0.25595147351442515 1.0 O43929
Slc transporter disorders 1 54 0.7558628065082882 0.7363690750519482 1.0 P55735
Rna polymerase ii transcription termination 0 66 0.0 1.0 1.0
Rna polymerase i transcription termination 0 32 0.0 1.0 1.0
Mitotic prophase 2 93 0.8806396855177343 0.6653107346416252 1.0 P30154,P55735
Dna damage reversal 1 8 5.749566223250434 0.17885878423025256 1.0 Q6P6C2
Dectin 2 family 0 4 0.0 1.0 1.0
Release of hh np from the secreting cell 0 2 0.0 1.0 1.0
Rna polymerase iii transcription 0 44 0.0 1.0 1.0
Base excision repair ap site formation 0 23 0.0 1.0 1.0
Dna repair 10 291 1.4454678668620473 0.1720935215719347 1.0 O94782,O95551,P27695,P35244,P35250,P39748,Q6P6C2,Q99504,Q9NXR7,Q9UGN5
Cd209 dc sign signaling 0 18 0.0 1.0 1.0
Rna polymerase ii transcription 22 969 0.9252413303305268 0.6666716912752139 1.0 O14727,P11474,P12931,P19784,P25787,P25789,P30154,P35244,P35250,P42575,P49720,P55036,P55212,P63208,Q00534,Q13951,Q8N0Z6,Q99873,Q9UBL3,Q9UHY1,Q9UIV1,Q9UL46
Pyroptosis 0 16 0.0 1.0 1.0
Mitotic telophase cytokinesis 0 13 0.0 1.0 1.0
Death receptor signalling 1 120 0.33439934678324773 0.948823365315595 1.0 P42575
Bbsome mediated cargo targeting to cilium 0 18 0.0 1.0 1.0
Cargo trafficking to the periciliary membrane 2 43 1.9645052548086457 0.2813288077075832 1.0 O00471,O60645
G2 phase 0 4 0.0 1.0 1.0
Rna polymerase i transcription 0 63 0.0 1.0 1.0
Signaling by retinoic acid 0 26 0.0 1.0 1.0
Pyrimidine salvage 0 9 0.0 1.0 1.0
Pyruvate metabolism 0 26 0.0 1.0 1.0
Mitochondrial translation 2 93 0.8806396855177343 0.6653107346416252 1.0 P82663,Q9BYD3
Recycling of eif2 gdp 0 8 0.0 1.0 1.0
Transcriptional regulation by small rnas 1 57 0.7151532677848468 0.755241359516926 1.0 P55735
Tryptophan catabolism 0 6 0.0 1.0 1.0
Phase 2 plateau phase 0 3 0.0 1.0 1.0
Phase 0 rapid depolarisation 0 6 0.0 1.0 1.0
G2 m dna damage checkpoint 3 66 1.9212827988338192 0.21638336859425822 1.0 P35244,P35250,Q9NXR7
G2 m dna replication checkpoint 0 5 0.0 1.0 1.0
Cardiac conduction 1 43 0.9548872180451128 0.6539058419658339 1.0 P23634
Lysine catabolism 0 11 0.0 1.0 1.0
Phase 3 rapid repolarisation 0 1 0.0 1.0 1.0
Phase 4 resting membrane potential 0 2 0.0 1.0 1.0
Metabolism of lipids 7 508 0.5476929957512361 0.9673823902077467 1.0 O43772,P11474,P19784,P55809,Q03426,Q13614,Q15392
Organic cation anion zwitterion transport 0 3 0.0 1.0 1.0
Organic cation transport 0 3 0.0 1.0 1.0
Propionyl coa catabolism 0 5 0.0 1.0 1.0
Glycogen breakdown glycogenolysis 0 13 0.0 1.0 1.0
Histidine catabolism 0 3 0.0 1.0 1.0
Branched chain amino acid catabolism 0 22 0.0 1.0 1.0
Aflatoxin activation and detoxification 0 6 0.0 1.0 1.0
Urea cycle 0 6 0.0 1.0 1.0
Galactose catabolism 0 5 0.0 1.0 1.0
Fructose catabolism 0 3 0.0 1.0 1.0
Creatine metabolism 0 6 0.0 1.0 1.0
Transport of nucleotide sugars 0 4 0.0 1.0 1.0
Cyclin a b1 b2 associated events during g2 m transition 1 24 1.7470515754268614 0.44658711947191027 1.0 P30154
Physiological factors 0 6 0.0 1.0 1.0
Ra biosynthesis pathway 0 9 0.0 1.0 1.0
Diseases associated with glycosylation precursor biosynthesis 0 16 0.0 1.0 1.0
Clec7a dectin 1 induces nfat activation 0 10 0.0 1.0 1.0
Negative regulation of tcf dependent signaling by dvl interacting proteins 0 5 0.0 1.0 1.0
Processing of capped intron containing pre mrna 5 239 0.854173261580669 0.6953915681465679 1.0 O75940,P55735,P62314,Q15365,Q15366
Transport of mature transcript to cytoplasm 1 81 0.4993927125506073 0.8650033356775808 1.0 P55735
Mrna editing c to u conversion 0 2 0.0 1.0 1.0
Irak4 deficiency tlr2 4 0 4 0.0 1.0 1.0
Mrna splicing 4 188 0.8699215965787598 0.6754179103257936 1.0 O75940,P62314,Q15365,Q15366
Mrna splicing minor pathway 1 52 0.7856632531555132 0.7229893066875739 1.0 P62314
Mrna capping 0 29 0.0 1.0 1.0
Ikba variant leads to eda id 0 7 0.0 1.0 1.0
Pyruvate metabolism and citric acid tca cycle 0 48 0.0 1.0 1.0
Piwi interacting rna pirna biogenesis 0 16 0.0 1.0 1.0
Citric acid cycle tca cycle 0 21 0.0 1.0 1.0
G1 s specific transcription 0 29 0.0 1.0 1.0
Metabolism of carbohydrates 5 201 1.0237675317040396 0.5433416511109587 1.0 A6NDG6,P09972,P30154,P55735,Q9Y315
Metabolic disorders of biological oxidation enzymes 0 13 0.0 1.0 1.0
Ethanol oxidation 0 5 0.0 1.0 1.0
Pentose phosphate pathway 1 13 3.3522267206477734 0.2740704871267072 1.0 Q9Y315
Ion homeostasis 1 31 1.3384615384615384 0.534424974066877 1.0 P23634
Diseases of mismatch repair mmr 0 5 0.0 1.0 1.0
Gluconeogenesis 1 25 1.674089068825911 0.46007968674438166 1.0 P09972
Frs mediated fgfr4 signaling 0 9 0.0 1.0 1.0
Cooperation of pdcl phlp1 and tric cct in g protein beta folding 1 27 1.5450015571473061 0.48608975697343193 1.0 P19784
Diseases of metabolism 0 131 0.0 1.0 1.0
Tnfs bind their physiological receptors 0 1 0.0 1.0 1.0
Raf activation 2 33 2.600839234198794 0.1911341037783432 1.0 P12931,P30154
Map2k and mapk activation 2 31 2.7807681525091112 0.17353156820691468 1.0 P12931,P30086
Constitutive signaling by akt1 e17k in cancer 1 25 1.674089068825911 0.46007968674438166 1.0 Q96B36
Negative feedback regulation of mapk pathway 0 6 0.0 1.0 1.0
Tnf receptor superfamily tnfsf members mediating non canonical nf kb pathway 0 5 0.0 1.0 1.0
Protein repair 0 5 0.0 1.0 1.0
Lgi adam interactions 0 5 0.0 1.0 1.0
Surfactant metabolism 0 8 0.0 1.0 1.0
Map3k8 tpl2 dependent mapk1 3 activation 1 14 3.094051697290564 0.2917500038862815 1.0 P63208
Hdr through single strand annealing ssa 2 35 2.442719881744272 0.20895917602195896 1.0 P35244,P35250
Phospholipase c mediated cascade fgfr2 0 3 0.0 1.0 1.0
Hdr through homologous recombination hrr 2 66 1.255589430894309 0.47980986419599986 1.0 P35244,P35250
Phospholipase c mediated cascade fgfr4 0 3 0.0 1.0 1.0
Regulation of tlr by endogenous ligand 0 3 0.0 1.0 1.0
Fructose metabolism 0 5 0.0 1.0 1.0
Josephin domain dubs 0 9 0.0 1.0 1.0
Ovarian tumor domain proteases 1 34 1.216415163783585 0.5676800659750835 1.0 Q96FW1
Metalloprotease dubs 1 20 2.1157042403579798 0.3891747515056749 1.0 Q9NXR7
Cd22 mediated bcr regulation 0 2 0.0 1.0 1.0
Resolution of d loop structures 0 32 0.0 1.0 1.0
Sensing of dna double strand breaks 0 6 0.0 1.0 1.0
Resolution of d loop structures through synthesis dependent strand annealing sdsa 0 26 0.0 1.0 1.0
Nonhomologous end joining nhej 2 41 2.0656660412757972 0.26317889352468227 1.0 O95551,Q9NXR7
Apex1 independent resolution of ap sites via the single nucleotide replacement pathway 0 7 0.0 1.0 1.0
Homologous dna pairing and strand exchange 2 41 2.0656660412757972 0.26317889352468227 1.0 P35244,P35250
Dna double strand break response 2 49 1.7126794672202041 0.3354134477865137 1.0 Q99504,Q9NXR7
Processing of dna double strand break ends 3 66 1.9212827988338192 0.21638336859425822 1.0 P35244,P35250,Q9NXR7
Cargo concentration in the er 0 23 0.0 1.0 1.0
Diseases associated with surfactant metabolism 0 1 0.0 1.0 1.0
Rho gtpases activate nadph oxidases 0 13 0.0 1.0 1.0
Downstream signaling of activated fgfr1 0 15 0.0 1.0 1.0
Rho gtpases activate rhotekin and rhophilins 1 8 5.749566223250434 0.17885878423025256 1.0 P08134
Downstream signaling of activated fgfr4 0 14 0.0 1.0 1.0
Shc mediated cascade fgfr4 0 8 0.0 1.0 1.0
Pi 3k cascade fgfr4 0 8 0.0 1.0 1.0
Negative regulation of fgfr1 signaling 1 17 2.513157894736842 0.3422564852890665 1.0 P12931
Negative regulation of fgfr2 signaling 1 17 2.513157894736842 0.3422564852890665 1.0 P12931
Negative regulation of fgfr3 signaling 1 17 2.513157894736842 0.3422564852890665 1.0 P12931
Negative regulation of fgfr4 signaling 1 17 2.513157894736842 0.3422564852890665 1.0 P12931
Signaling by fgfr1 1 28 1.4876293297345928 0.4986229205358068 1.0 P12931
Downstream signaling of activated fgfr3 0 14 0.0 1.0 1.0
Frs mediated fgfr3 signaling 0 9 0.0 1.0 1.0
Signaling by fgfr2 1 51 0.8014574898785425 0.7160479454809648 1.0 P12931
Signaling by fgfr3 1 27 1.5450015571473061 0.48608975697343193 1.0 P12931
Signaling by fgfr4 1 26 1.6069635627530365 0.47324459065334146 1.0 P12931
Signaling by fgfr2 in disease 0 28 0.0 1.0 1.0
Signaling by fgfr4 in disease 0 11 0.0 1.0 1.0
Signaling by fgfr1 in disease 0 29 0.0 1.0 1.0
Termination of translesion dna synthesis 2 34 2.519308943089431 0.20002281093894894 1.0 P35244,P35250
Shc mediated cascade fgfr1 0 8 0.0 1.0 1.0
Pi 3k cascade fgfr1 0 8 0.0 1.0 1.0
Rho gtpases activate wasps and waves 2 33 2.600839234198794 0.1911341037783432 1.0 O15145,Q9Y6W5
Frs mediated fgfr1 signaling 0 9 0.0 1.0 1.0
Pi 3k cascade fgfr2 0 8 0.0 1.0 1.0
Diseases of carbohydrate metabolism 0 23 0.0 1.0 1.0
Dna damage recognition in gg ner 1 37 1.114709851551957 0.5985687060361295 1.0 Q9UGN5
Formation of xylulose 5 phosphate 0 5 0.0 1.0 1.0
Clec7a inflammasome pathway 0 4 0.0 1.0 1.0
Downstream signaling of activated fgfr2 0 14 0.0 1.0 1.0
Response to metal ions 0 5 0.0 1.0 1.0
Fgfrl1 modulation of fgfr1 signaling 0 2 0.0 1.0 1.0
Frs mediated fgfr2 signaling 0 9 0.0 1.0 1.0
Shc mediated cascade fgfr3 0 8 0.0 1.0 1.0
Metallothioneins bind metals 0 2 0.0 1.0 1.0
Formation of incision complex in gg ner 2 42 2.013821138211382 0.27225579108735287 1.0 P35244,Q9UGN5
Nucleotide excision repair 3 114 1.0851627137341424 0.5273610384469327 1.0 P35244,P35250,Q9UGN5
Global genome nucleotide excision repair gg ner 3 87 1.4379008746355686 0.3552020223242721 1.0 P35244,P35250,Q9UGN5
Ligand receptor interactions 0 2 0.0 1.0 1.0
Tp53 regulates transcription of death receptors and ligands 0 10 0.0 1.0 1.0
Fgfr2 alternative splicing 0 26 0.0 1.0 1.0
Tp53 regulates transcription of genes involved in g2 cell cycle arrest 1 18 2.3650869254584426 0.3582816735878424 1.0 Q99873
Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 1 16 2.6809716599190283 0.3258327648280404 1.0 Q9UIV1
Pi 3k cascade fgfr3 0 8 0.0 1.0 1.0
Regulation of tp53 activity through phosphorylation 3 82 1.5296822526478946 0.3217703689336544 1.0 P19784,P35244,P35250
Regulation of tp53 activity through acetylation 0 30 0.0 1.0 1.0
Regulation of tp53 activity through association with co factors 0 12 0.0 1.0 1.0
Tp53 regulates metabolic genes 0 84 0.0 1.0 1.0
Regulation of tp53 activity through methylation 1 16 2.6809716599190283 0.3258327648280404 1.0 Q8N0Z6
Keratinization 0 24 0.0 1.0 1.0
Regulation of tp53 expression and degradation 1 33 1.2545546558704452 0.5568666172945154 1.0 P30154
Metabolism of fat soluble vitamins 0 29 0.0 1.0 1.0
Signaling by met 3 64 1.984677149548344 0.20371222353826346 1.0 P12931,P46109,P62330
Met receptor activation 0 4 0.0 1.0 1.0
Negative regulation of met activity 0 20 0.0 1.0 1.0
Rho gtpases activate pkns 1 40 1.028651510432887 0.6272586592143582 1.0 P08134
Pi5p regulates tp53 acetylation 0 9 0.0 1.0 1.0
Retrograde transport at the trans golgi network 1 49 0.8350202429149798 0.7016412630610651 1.0 Q96JB2
Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3 0 14 0.0 1.0 1.0
Rho gtpases activate cit 1 18 2.3650869254584426 0.3582816735878424 1.0 P08134
Intra golgi traffic 2 42 2.013821138211382 0.27225579108735287 1.0 P33908,Q96JB2
Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain 0 11 0.0 1.0 1.0
Rho gtpases activate ktn1 0 11 0.0 1.0 1.0
Rho gtpases activate iqgaps 1 26 1.6069635627530365 0.47324459065334146 1.0 P04350
Formation of the cornified envelope 0 24 0.0 1.0 1.0
Tnfr1 mediated ceramide production 0 3 0.0 1.0 1.0
Rho gtpases activate rocks 1 19 2.233468286099865 0.373917962138579 1.0 P08134
Rho gtpases activate paks 0 19 0.0 1.0 1.0
Rna polymerase ii transcribes snrna genes 0 73 0.0 1.0 1.0
Copi dependent golgi to er retrograde traffic 2 83 0.9903643480879253 0.6035333818702558 1.0 P04350,P84085
Glycerophospholipid catabolism 0 4 0.0 1.0 1.0
Tp53 regulates transcription of genes involved in cytochrome c release 0 16 0.0 1.0 1.0
Signaling by moderate kinase activity braf mutants 2 36 2.3706360593017695 0.21793566077271245 1.0 P12931,P30086
Constitutive signaling by egfrviii 0 14 0.0 1.0 1.0
Deposition of new cenpa containing nucleosomes at the centromere 1 34 1.216415163783585 0.5676800659750835 1.0 Q92674
Gli proteins bind promoters of hh responsive genes to promote transcription 0 2 0.0 1.0 1.0
Respiratory electron transport 1 101 0.39870445344129557 0.9178698620696751 1.0 Q9UDW1
Inflammasomes 1 12 3.6573426573426575 0.25595147351442515 1.0 Q9Y2Z0
Presynaptic nicotinic acetylcholine receptors 0 2 0.0 1.0 1.0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors 0 1 0.0 1.0 1.0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 0 2 0.0 1.0 1.0
Highly calcium permeable nicotinic acetylcholine receptors 0 2 0.0 1.0 1.0
Formation of tc ner pre incision complex 0 53 0.0 1.0 1.0
Transcription coupled nucleotide excision repair tc ner 2 82 1.0028455284552846 0.5969051653450472 1.0 P35244,P35250
Dual incision in tc ner 2 67 1.2361475922451532 0.48771846009601133 1.0 P35244,P35250
Synthesis of wybutosine at g37 of trna phe 0 6 0.0 1.0 1.0
Fanconi anemia pathway 2 36 2.3706360593017695 0.21793566077271245 1.0 O94782,P35244
Interleukin 6 family signaling 0 10 0.0 1.0 1.0
Activation of smo 0 11 0.0 1.0 1.0
Interleukin 10 signaling 0 6 0.0 1.0 1.0
Regulation of tp53 activity 5 146 1.4311356273531215 0.2825268363638501 1.0 P19784,P30154,P35244,P35250,Q8N0Z6
Complex i biogenesis 0 56 0.0 1.0 1.0
Choline catabolism 0 4 0.0 1.0 1.0
Tp53 regulates transcription of dna repair genes 0 61 0.0 1.0 1.0
Protein protein interactions at synapses 1 46 0.8909581646423752 0.6786551558910596 1.0 O95197
Neurexins and neuroligins 0 28 0.0 1.0 1.0
Antimicrobial peptides 0 7 0.0 1.0 1.0
Rrna modification in the mitochondrion 0 6 0.0 1.0 1.0
Il 6 type cytokine receptor ligand interactions 0 6 0.0 1.0 1.0
Trna modification in the mitochondrion 0 9 0.0 1.0 1.0
Interleukin 4 and interleukin 13 signaling 1 40 1.028651510432887 0.6272586592143582 1.0 Q07820
Erbb2 regulates cell motility 0 6 0.0 1.0 1.0
Trna processing in the mitochondrion 0 5 0.0 1.0 1.0
Trna processing in the nucleus 2 60 1.386319035604149 0.43085078339507943 1.0 O43592,P55735
Tp53 regulates transcription of cell cycle genes 2 43 1.9645052548086457 0.2813288077075832 1.0 Q99873,Q9UIV1
Tp53 regulates transcription of genes involved in g1 cell cycle arrest 0 13 0.0 1.0 1.0
Interleukin 6 signaling 0 8 0.0 1.0 1.0
Signal attenuation 0 9 0.0 1.0 1.0
Hcmv infection 4 102 1.6477082636333222 0.23639268355602783 1.0 P04350,P55735,Q96FJ2,Q99816
Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0 19 0.0 1.0 1.0
Protein localization 0 142 0.0 1.0 1.0
Flt3 signaling 0 27 0.0 1.0 1.0
Diseases of base excision repair 0 4 0.0 1.0 1.0
Class i peroxisomal membrane protein import 0 19 0.0 1.0 1.0
Traf6 mediated induction of tak1 complex within tlr4 complex 1 11 4.0234817813765185 0.2373820829012167 1.0 Q6SZW1
Irak2 mediated activation of tak1 complex 0 9 0.0 1.0 1.0
Hcmv early events 3 79 1.590547798066595 0.30170950832348975 1.0 P04350,P55735,Q96FJ2
Ikk complex recruitment mediated by rip1 1 16 2.6809716599190283 0.3258327648280404 1.0 Q6SZW1
Activation of irf3 irf7 mediated by tbk1 ikk epsilon 1 11 4.0234817813765185 0.2373820829012167 1.0 Q6SZW1
Ion transport by p type atpases 1 31 1.3384615384615384 0.534424974066877 1.0 P23634
Negative regulators of ddx58 ifih1 signaling 1 29 1.434355118565645 0.510851629797044 1.0 Q15366
Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10 0 13 0.0 1.0 1.0
Traf6 mediated nf kb activation 0 22 0.0 1.0 1.0
Traf6 mediated irf7 activation 0 15 0.0 1.0 1.0
Traf3 dependent irf activation pathway 0 13 0.0 1.0 1.0
Transferrin endocytosis and recycling 0 18 0.0 1.0 1.0
Irak1 recruits ikk complex 0 12 0.0 1.0 1.0
Iron uptake and transport 2 38 2.238482384823848 0.23598050315708816 1.0 O76003,P63208
Assembly and cell surface presentation of nmda receptors 1 28 1.4876293297345928 0.4986229205358068 1.0 P04350
Lipophagy 0 8 0.0 1.0 1.0
Regulation of glycolysis by fructose 2 6 bisphosphate metabolism 1 11 4.0234817813765185 0.2373820829012167 1.0 P30154
Constitutive signaling by overexpressed erbb2 0 11 0.0 1.0 1.0
Nr1h2 nr1h3 regulate gene expression linked to gluconeogenesis 0 4 0.0 1.0 1.0
Nr1h2 nr1h3 regulate gene expression to control bile acid homeostasis 0 6 0.0 1.0 1.0
Long term potentiation 1 11 4.0234817813765185 0.2373820829012167 1.0 P12931
Egr2 and sox10 mediated initiation of schwann cell myelination 0 20 0.0 1.0 1.0
Activation of ampk downstream of nmdars 1 21 2.0097165991902832 0.4040612158985918 1.0 P04350
Activation of rac1 downstream of nmdars 0 6 0.0 1.0 1.0
Hcmv late events 2 62 1.3398373983739837 0.447448107055433 1.0 P55735,Q99816
Foxo mediated transcription of cell cycle genes 0 13 0.0 1.0 1.0
Negative regulation of nmda receptor mediated neuronal transmission 0 14 0.0 1.0 1.0
Transcriptional regulation of granulopoiesis 1 34 1.216415163783585 0.5676800659750835 1.0 Q13951
Postmitotic nuclear pore complex npc reformation 1 27 1.5450015571473061 0.48608975697343193 1.0 P55735
Foxo mediated transcription of oxidative stress metabolic and neuronal genes 0 18 0.0 1.0 1.0
Foxo mediated transcription of cell death genes 0 12 0.0 1.0 1.0
Regulation of localization of foxo transcription factors 0 13 0.0 1.0 1.0
Foxo mediated transcription 0 47 0.0 1.0 1.0
Chaperone mediated autophagy 1 16 2.6809716599190283 0.3258327648280404 1.0 Q99497
Regulation of foxo transcriptional activity by acetylation 0 10 0.0 1.0 1.0
Estrogen stimulated signaling through prkcz 0 6 0.0 1.0 1.0
Endosomal sorting complex required for transport escrt 1 30 1.3847549909255898 0.5227832512917782 1.0 Q99816
Interferon signaling 3 128 0.9622530612244898 0.6061807665031014 1.0 P52294,P55735,Q13325
Erythropoietin activates phospholipase c gamma plcg 0 5 0.0 1.0 1.0
Erythropoietin activates phosphoinositide 3 kinase pi3k 0 8 0.0 1.0 1.0
Activated ntrk2 signals through ras 0 6 0.0 1.0 1.0
Nr1h2 and nr1h3 mediated signaling 0 31 0.0 1.0 1.0
Mecp2 regulates transcription factors 0 4 0.0 1.0 1.0
Mecp2 regulates transcription of neuronal ligands 0 4 0.0 1.0 1.0
Mecp2 regulates neuronal receptors and channels 0 12 0.0 1.0 1.0
Regulation of mecp2 expression and activity 0 30 0.0 1.0 1.0
Erythropoietin activates stat5 0 4 0.0 1.0 1.0
Loss of mecp2 binding ability to the ncor smrt complex 0 7 0.0 1.0 1.0
Interleukin 27 signaling 0 8 0.0 1.0 1.0
Interleukin 23 signaling 0 5 0.0 1.0 1.0
Interleukin 2 signaling 0 5 0.0 1.0 1.0
Biosynthesis of maresins 0 1 0.0 1.0 1.0
Biosynthesis of epa derived spms 0 3 0.0 1.0 1.0
Biosynthesis of specialized proresolving mediators spms 0 6 0.0 1.0 1.0
Estrogen dependent gene expression 2 90 0.9109386548410938 0.6476315526587827 1.0 Q13951,Q99873
Noncanonical activation of notch3 0 8 0.0 1.0 1.0
Interleukin 21 signaling 0 5 0.0 1.0 1.0
O linked glycosylation of mucins 0 22 0.0 1.0 1.0
Erythropoietin activates ras 1 11 4.0234817813765185 0.2373820829012167 1.0 P46109
Activated ntrk2 signals through frs2 and frs3 0 7 0.0 1.0 1.0
Regulation of ifna signaling 0 8 0.0 1.0 1.0
Regulation of signaling by cbl 1 18 2.3650869254584426 0.3582816735878424 1.0 P46109
Interleukin receptor shc signaling 0 14 0.0 1.0 1.0
Meiotic recombination 1 31 1.3384615384615384 0.534424974066877 1.0 P35244
Interferon alpha beta signaling 1 31 1.3384615384615384 0.534424974066877 1.0 Q13325
Rhof gtpase cycle 1 42 0.9782758961192851 0.6452412597701435 1.0 O00161
Activated ntrk3 signals through ras 0 6 0.0 1.0 1.0
Signaling by ntrk3 trkc 1 15 2.8727588201272414 0.30900064216985557 1.0 P12931
Activated ntrk2 signals through pi3k 0 4 0.0 1.0 1.0
Blood group systems biosynthesis 0 5 0.0 1.0 1.0
Peroxisomal protein import 0 51 0.0 1.0 1.0
Activated ntrk2 signals through cdk5 0 3 0.0 1.0 1.0
Ntrk2 activates rac1 0 3 0.0 1.0 1.0
Ngf stimulated transcription 0 22 0.0 1.0 1.0
Nr1h2 nr1h3 regulate gene expression linked to triglyceride lipolysis in adipose 0 3 0.0 1.0 1.0
Nr1h2 nr1h3 regulate gene expression to limit cholesterol uptake 0 3 0.0 1.0 1.0
Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux 0 26 0.0 1.0 1.0
Nr1h2 nr1h3 regulate gene expression linked to lipogenesis 0 7 0.0 1.0 1.0
Tysnd1 cleaves peroxisomal proteins 0 7 0.0 1.0 1.0
Interleukin 36 pathway 0 1 0.0 1.0 1.0
Estrogen dependent nuclear events downstream of esr membrane signaling 0 15 0.0 1.0 1.0
Infection with mycobacterium tuberculosis 1 21 2.0097165991902832 0.4040612158985918 1.0 P52294
Flt3 signaling by cbl mutants 0 4 0.0 1.0 1.0
Flt3 signaling through src family kinases 0 2 0.0 1.0 1.0
Negative regulation of flt3 0 8 0.0 1.0 1.0
Rhobtb3 atpase cycle 0 9 0.0 1.0 1.0
Inactivation of csf3 g csf signaling 0 17 0.0 1.0 1.0
Signaling by flt3 itd and tkd mutants 0 12 0.0 1.0 1.0
Signaling by flt3 fusion proteins 0 16 0.0 1.0 1.0
Stat5 activation downstream of flt3 itd mutants 0 6 0.0 1.0 1.0
Rhobtb gtpase cycle 1 33 1.2545546558704452 0.5568666172945154 1.0 Q15208
Stat3 nuclear events downstream of alk signaling 0 6 0.0 1.0 1.0
Rnd1 gtpase cycle 0 36 0.0 1.0 1.0
Rnd2 gtpase cycle 0 40 0.0 1.0 1.0
Rnd3 gtpase cycle 1 39 1.0558278286810143 0.6179297811879729 1.0 Q13492
Translation of sars cov 2 structural proteins 2 41 2.0656660412757972 0.26317889352468227 1.0 Q96SB4,Q99873
Attachment and entry 0 4 0.0 1.0 1.0
Maturation of sars cov 2 spike protein 0 24 0.0 1.0 1.0
Sars cov 2 infection 2 62 1.3398373983739837 0.447448107055433 1.0 Q96SB4,Q99873
Defective ripk1 mediated regulated necrosis 0 6 0.0 1.0 1.0
Alk mutants bind tkis 0 12 0.0 1.0 1.0
Transcriptional regulation of testis differentiation 0 4 0.0 1.0 1.0
Heme signaling 0 36 0.0 1.0 1.0
Sensory perception 3 84 1.491609977324263 0.335153532230544 1.0 P23634,P47755,Q14651
Antigen activates b cell receptor bcr leading to generation of second messengers 0 20 0.0 1.0 1.0
Factors involved in megakaryocyte development and platelet production 3 117 1.056283566058002 0.5449777526272358 1.0 P04350,P47755,Q8IWA4
Kinesins 1 47 0.871501496215455 0.6865067343299582 1.0 P04350
Antigen presentation folding assembly and peptide loading of class i mhc 1 24 1.7470515754268614 0.44658711947191027 1.0 P55735
Growth hormone receptor signaling 0 15 0.0 1.0 1.0
Gaba b receptor activation 1 16 2.6809716599190283 0.3258327648280404 1.0 P63096
Gaba receptor activation 1 18 2.3650869254584426 0.3582816735878424 1.0 P63096
Serine biosynthesis 0 7 0.0 1.0 1.0
Regulation of bach1 activity 1 10 4.470985155195682 0.21835116687336614 1.0 P63208
Amyloid fiber formation 0 41 0.0 1.0 1.0
Reactions specific to the complex n glycan synthesis pathway 0 6 0.0 1.0 1.0
N glycan antennae elongation 0 8 0.0 1.0 1.0
N glycan antennae elongation in the medial trans golgi 0 15 0.0 1.0 1.0
Traf6 mediated irf7 activation in tlr7 8 or 9 signaling 0 10 0.0 1.0 1.0
Defective intrinsic pathway for apoptosis 0 24 0.0 1.0 1.0
Sensory perception of taste 0 4 0.0 1.0 1.0
Signaling by rho gtpases miro gtpases and rhobtb3 18 593 1.2757202268431003 0.19572246624427586 1.0 O00161,O15145,P04350,P08134,P12931,P30154,P50748,P55735,Q13492,Q15208,Q15642,Q8IW35,Q8IWA4,Q92674,Q96EA4,Q96FJ2,Q9P258,Q9Y6W5
Miro gtpase cycle 1 8 5.749566223250434 0.17885878423025256 1.0 Q8IWA4
Termination of o glycan biosynthesis 0 4 0.0 1.0 1.0
Suppression of apoptosis 0 6 0.0 1.0 1.0
Aberrant regulation of mitotic exit in cancer due to rb1 defects 0 20 0.0 1.0 1.0
Maturation of sars cov 1 spike protein 0 5 0.0 1.0 1.0
Anti inflammatory response favouring leishmania parasite infection 2 46 1.8300073909830008 0.30847420249713686 1.0 P12931,P63096
Cd163 mediating an anti inflammatory response 0 5 0.0 1.0 1.0
Defective factor viii causes hemophilia a 0 3 0.0 1.0 1.0
Purinergic signaling in leishmaniasis infection 1 12 3.6573426573426575 0.25595147351442515 1.0 Q9Y2Z0
Adora2b mediated anti inflammatory cytokines production 1 30 1.3847549909255898 0.5227832512917782 1.0 P63096
Signaling by mras complex mutants 0 8 0.0 1.0 1.0
Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects 1 17 2.513157894736842 0.3422564852890665 1.0 Q00534
Defects of contact activation system cas and kallikrein kinin system kks 0 5 0.0 1.0 1.0
Fcgr3a mediated il10 synthesis 1 23 1.826647037173353 0.43275876738054964 1.0 P12931
Response of eif2ak1 hri to heme deficiency 0 10 0.0 1.0 1.0
Diseases of programmed cell death 1 53 0.7704764870756774 0.7297616501401488 1.0 P49643
Alpha protein kinase 1 signaling pathway 0 9 0.0 1.0 1.0
Stat5 activation 0 4 0.0 1.0 1.0
Amino acids regulate mtorc1 1 45 0.9112992270887008 0.6706077438596076 1.0 P55735
Response of mtb to phagocytosis 1 20 2.1157042403579798 0.3891747515056749 1.0 P52294
Suppression of phagosomal maturation 1 11 4.0234817813765185 0.2373820829012167 1.0 P52294
Modulation by mtb of host immune system 0 4 0.0 1.0 1.0
Prevention of phagosomal lysosomal fusion 0 8 0.0 1.0 1.0
Ras processing 0 19 0.0 1.0 1.0
Translation of sars cov 1 structural proteins 0 22 0.0 1.0 1.0
Killing mechanisms 0 9 0.0 1.0 1.0
Signaling by erbb2 ecd mutants 0 15 0.0 1.0 1.0
Maturation of protein 3a 0 5 0.0 1.0 1.0
Maturation of sars cov 1 nucleoprotein 0 9 0.0 1.0 1.0
Flt3 signaling in disease 0 22 0.0 1.0 1.0
Sars cov infections 4 128 1.298783712321523 0.37857979676578396 1.0 P07437,P62942,Q96SB4,Q99873
Translation of replicase and assembly of the replication transcription complex 0 13 0.0 1.0 1.0
Potential therapeutics for sars 2 68 1.2172949002217295 0.4955518992738811 1.0 P07437,P62942
Sars cov 1 infection 0 42 0.0 1.0 1.0
Diseases of dna repair 0 33 0.0 1.0 1.0
Pexophagy 0 9 0.0 1.0 1.0
Diseases of mitotic cell cycle 1 38 1.084473137104716 0.6083683872182535 1.0 Q00534
Signaling by membrane tethered fusions of pdgfra or pdgfrb 0 3 0.0 1.0 1.0
Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants 0 11 0.0 1.0 1.0
Defective f9 activation 0 1 0.0 1.0 1.0
Signaling by pdgfr in disease 0 17 0.0 1.0 1.0
Inhibition of dna recombination at telomere 0 28 0.0 1.0 1.0
Signaling by kit in disease 1 18 2.3650869254584426 0.3582816735878424 1.0 P12931
Sealing of the nuclear envelope ne by escrt iii 1 26 1.6069635627530365 0.47324459065334146 1.0 P04350
Defective factor ix causes hemophilia b 0 3 0.0 1.0 1.0
Signaling by csf3 g csf 0 22 0.0 1.0 1.0
Irs activation 0 4 0.0 1.0 1.0
Ticam1 traf6 dependent induction of tak1 complex 0 10 0.0 1.0 1.0
Tlr3 mediated ticam1 dependent programmed cell death 0 5 0.0 1.0 1.0
Downregulation of erbb2 signaling 0 18 0.0 1.0 1.0
Ptk6 promotes hif1a stabilization 0 2 0.0 1.0 1.0
Cargo recognition for clathrin mediated endocytosis 2 78 1.0560547710740265 0.5695689628304602 1.0 P52594,Q13492
Interleukin 20 family signaling 0 11 0.0 1.0 1.0
Tbc rabgaps 2 39 2.177763128982641 0.2450354162713742 1.0 P62330,Q9NVG8
Transcriptional regulation by ventx 0 37 0.0 1.0 1.0
Ret signaling 1 26 1.6069635627530365 0.47324459065334146 1.0 P12931
Signaling by fgfr3 fusions in cancer 0 10 0.0 1.0 1.0
Transcriptional regulation by the ap 2 tfap2 family of transcription factors 0 27 0.0 1.0 1.0
Signaling by mst1 0 3 0.0 1.0 1.0
Met activates pi3k akt signaling 0 6 0.0 1.0 1.0
Met activates ras signaling 0 11 0.0 1.0 1.0
Signaling by fgfr2 iiia tm 0 18 0.0 1.0 1.0
Butyrophilin btn family interactions 0 5 0.0 1.0 1.0
Phosphate bond hydrolysis by ntpdase proteins 0 4 0.0 1.0 1.0
Synaptic adhesion like molecules 1 11 4.0234817813765185 0.2373820829012167 1.0 O95197
Ptk6 expression 0 2 0.0 1.0 1.0
Ptk6 regulates rho gtpases ras gtpase and map kinases 0 13 0.0 1.0 1.0
Protein ubiquitination 1 58 0.702535691455359 0.7612281573002204 1.0 Q14527
Ptk6 regulates cell cycle 0 5 0.0 1.0 1.0
Met activates ptpn11 0 5 0.0 1.0 1.0
Vldl assembly 0 3 0.0 1.0 1.0
Inla mediated entry of listeria monocytogenes into host cells 1 9 5.030364372469635 0.1988473022417859 1.0 P12931
Listeria monocytogenes entry into host cells 1 21 2.0097165991902832 0.4040612158985918 1.0 P12931
Rab gefs exchange gtp for gdp on rabs 0 79 0.0 1.0 1.0
Met activates rap1 and rac1 1 11 4.0234817813765185 0.2373820829012167 1.0 P46109
Met interacts with tns proteins 0 4 0.0 1.0 1.0
Inlb mediated entry of listeria monocytogenes into host cell 0 15 0.0 1.0 1.0
Creb3 factors activate genes 0 3 0.0 1.0 1.0
Met activates ptk2 signaling 1 19 2.233468286099865 0.373917962138579 1.0 P12931
Reelin signalling pathway 0 3 0.0 1.0 1.0
Rab geranylgeranylation 1 54 0.7558628065082882 0.7363690750519482 1.0 Q9BZG1
Rrna processing in the mitochondrion 0 10 0.0 1.0 1.0
Tfap2 ap 2 family regulates transcription of cell cycle factors 0 5 0.0 1.0 1.0
Tfap2 ap 2 family regulates transcription of growth factors and their receptors 0 7 0.0 1.0 1.0
Activation of the tfap2 ap 2 family of transcription factors 0 8 0.0 1.0 1.0
Negative regulation of activity of tfap2 ap 2 family transcription factors 0 7 0.0 1.0 1.0
E3 ubiquitin ligases ubiquitinate target proteins 1 40 1.028651510432887 0.6272586592143582 1.0 Q14527
Synthesis of active ubiquitin roles of e1 and e2 enzymes 0 26 0.0 1.0 1.0
Vldlr internalisation and degradation 0 9 0.0 1.0 1.0
Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation 0 5 0.0 1.0 1.0
Protein methylation 1 16 2.6809716599190283 0.3258327648280404 1.0 O60678
Ptk6 regulates rtks and their effectors akt1 and dok1 0 7 0.0 1.0 1.0
Wax and plasmalogen biosynthesis 0 5 0.0 1.0 1.0
Rna polymerase iii transcription initiation from type 3 promoter 0 30 0.0 1.0 1.0
Rna polymerase iii transcription initiation from type 1 promoter 0 31 0.0 1.0 1.0
Platelet aggregation plug formation 1 20 2.1157042403579798 0.3891747515056749 1.0 P12931
Response to elevated platelet cytosolic ca2 1 71 0.5713128976286871 0.8269899568539123 1.0 Q9NUQ9
Platelet activation signaling and aggregation 3 152 0.8052869469935625 0.7197649747672648 1.0 P12931,P63096,Q9NUQ9
Tnf signaling 0 39 0.0 1.0 1.0
Platelet adhesion to exposed collagen 0 7 0.0 1.0 1.0
Synthesis of very long chain fatty acyl coas 0 17 0.0 1.0 1.0
Synthesis of ketone bodies 0 6 0.0 1.0 1.0
Dissolution of fibrin clot 0 7 0.0 1.0 1.0
Fasl cd95l signaling 0 5 0.0 1.0 1.0
Triglyceride biosynthesis 0 7 0.0 1.0 1.0
Fatty acyl coa biosynthesis 0 29 0.0 1.0 1.0
Mrna editing 0 4 0.0 1.0 1.0
Processing of capped intronless pre mrna 0 29 0.0 1.0 1.0
Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 0 14 0.0 1.0 1.0
Signaling by insulin receptor 0 45 0.0 1.0 1.0
Insulin receptor signalling cascade 0 31 0.0 1.0 1.0
Trail signaling 0 6 0.0 1.0 1.0
Ptk6 regulates proteins involved in rna processing 0 3 0.0 1.0 1.0
Mitochondrial fatty acid beta oxidation of saturated fatty acids 0 9 0.0 1.0 1.0
Mitochondrial fatty acid beta oxidation 0 33 0.0 1.0 1.0
Signaling by ptk6 0 36 0.0 1.0 1.0
Erbb2 activates ptk6 signaling 0 3 0.0 1.0 1.0
Gastrin creb signalling pathway via pkc and mapk 0 14 0.0 1.0 1.0
Transport of organic anions 0 3 0.0 1.0 1.0
Advanced glycosylation endproduct receptor signaling 1 9 5.030364372469635 0.1988473022417859 1.0 P47755
Regulation of ifng signaling 0 10 0.0 1.0 1.0
Interferon gamma signaling 0 51 0.0 1.0 1.0
The nlrp3 inflammasome 1 10 4.470985155195682 0.21835116687336614 1.0 Q9Y2Z0
Mitochondrial fatty acid beta oxidation of unsaturated fatty acids 0 5 0.0 1.0 1.0
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0 8 0.0 1.0 1.0
Processing of intronless pre mrnas 0 21 0.0 1.0 1.0
Slbp dependent processing of replication dependent histone pre mrnas 0 10 0.0 1.0 1.0
Insulin receptor recycling 0 15 0.0 1.0 1.0
Beta oxidation of butanoyl coa to acetyl coa 0 5 0.0 1.0 1.0
Beta oxidation of hexanoyl coa to butanoyl coa 0 5 0.0 1.0 1.0
Beta oxidation of octanoyl coa to hexanoyl coa 0 5 0.0 1.0 1.0
Beta oxidation of decanoyl coa to octanoyl coa coa 0 6 0.0 1.0 1.0
Beta oxidation of lauroyl coa to decanoyl coa coa 0 4 0.0 1.0 1.0
Transport of fatty acids 0 3 0.0 1.0 1.0
Ticam1 dependent activation of irf3 irf7 0 10 0.0 1.0 1.0
Gaba synthesis release reuptake and degradation 0 12 0.0 1.0 1.0
Aryl hydrocarbon receptor signalling 0 7 0.0 1.0 1.0
Robo receptors bind akap5 0 8 0.0 1.0 1.0
Calnexin calreticulin cycle 0 23 0.0 1.0 1.0
Er quality control compartment erqc 0 18 0.0 1.0 1.0
Interleukin 37 signaling 0 12 0.0 1.0 1.0
Rab regulation of trafficking 2 107 0.762137049941928 0.7385266448910669 1.0 P62330,Q9NVG8
Signaling by tgfb family members 1 79 0.5123014637184677 0.858133021762938 1.0 P62942
Signaling by receptor tyrosine kinases 5 344 0.5832331840198114 0.9255324738131055 1.0 P12931,P30154,P46109,P62330,Q9Y6W5
Signaling by nuclear receptors 4 178 0.9208592425098926 0.633125287854137 1.0 P12931,P63096,Q13951,Q99873
Signaling by notch3 0 35 0.0 1.0 1.0
Signaling by erythropoietin 1 19 2.233468286099865 0.373917962138579 1.0 P46109
Loss of function of mecp2 in rett syndrome 0 12 0.0 1.0 1.0
Transcriptional regulation by mecp2 0 45 0.0 1.0 1.0
Interleukin 9 signaling 0 4 0.0 1.0 1.0
Interleukin 35 signalling 0 9 0.0 1.0 1.0
Oas antiviral response 0 6 0.0 1.0 1.0
Interleukin 15 signaling 0 8 0.0 1.0 1.0
Glycogen metabolism 0 20 0.0 1.0 1.0
Rhoa gtpase cycle 1 134 0.29877324891175305 0.9639047124976288 1.0 O00161
Signaling by ntrk2 trkb 1 18 2.3650869254584426 0.3582816735878424 1.0 P12931
Triglyceride metabolism 0 20 0.0 1.0 1.0
Rho gtpase cycle 8 387 0.8416007036059806 0.7303203362047571 1.0 O00161,P08134,P12931,Q13492,Q15208,Q15642,Q8IW35,Q9Y6W5
Rhoc gtpase cycle 1 75 0.5402122770543824 0.8433303264525713 1.0 P08134
Notch4 activation and transmission of signal to the nucleus 0 8 0.0 1.0 1.0
Notch4 intracellular domain regulates transcription 0 15 0.0 1.0 1.0
Notch3 intracellular domain regulates transcription 0 18 0.0 1.0 1.0
Notch3 activation and transmission of signal to the nucleus 0 18 0.0 1.0 1.0
Rhot1 gtpase cycle 0 5 0.0 1.0 1.0
Rhov gtpase cycle 1 35 1.1805191712312455 0.5782306803788487 1.0 Q8IW35
Rac3 gtpase cycle 2 83 0.9903643480879253 0.6035333818702558 1.0 O00161,Q9Y6W5
Rhobtb1 gtpase cycle 1 22 1.913823019086177 0.4185863086244521 1.0 Q15208
Rhob gtpase cycle 1 69 0.5882352941176471 0.8181940718302647 1.0 O00161
Rhou gtpase cycle 1 39 1.0558278286810143 0.6179297811879729 1.0 P12931
Rhoj gtpase cycle 1 55 0.7417903733693207 0.7428155815810851 1.0 O00161
Rhog gtpase cycle 0 71 0.0 1.0 1.0
Rhoh gtpase cycle 0 32 0.0 1.0 1.0
Rhoq gtpase cycle 2 59 1.410783055198973 0.42245382457760716 1.0 O00161,Q15642
Rhod gtpase cycle 0 50 0.0 1.0 1.0
Rac2 gtpase cycle 1 81 0.4993927125506073 0.8650033356775808 1.0 Q9Y6W5
Rac1 gtpase cycle 2 152 0.5310569105691056 0.8883827652021872 1.0 O00161,Q9Y6W5
Cdc42 gtpase cycle 1 134 0.29877324891175305 0.9639047124976288 1.0 O00161
Rhobtb2 gtpase cycle 1 22 1.913823019086177 0.4185863086244521 1.0 Q15208
Digestion 0 1 0.0 1.0 1.0
Metabolism of cofactors 1 15 2.8727588201272414 0.30900064216985557 1.0 Q5T2R2
G beta gamma signalling through cdc42 0 14 0.0 1.0 1.0
Carboxyterminal post translational modifications of tubulin 1 25 1.674089068825911 0.46007968674438166 1.0 P04350
Transcriptional regulation by e2f6 1 34 1.216415163783585 0.5676800659750835 1.0 O14727
Runx3 regulates bcl2l11 bim transcription 0 5 0.0 1.0 1.0
Runx3 regulates p14 arf 1 11 4.0234817813765185 0.2373820829012167 1.0 Q13951
Runx3 regulates yap1 mediated transcription 0 6 0.0 1.0 1.0
Runx3 regulates wnt signaling 0 8 0.0 1.0 1.0
Processing of smdt1 0 16 0.0 1.0 1.0
Cristae formation 0 27 0.0 1.0 1.0
Nucleotide salvage 0 20 0.0 1.0 1.0
Mitochondrial calcium ion transport 0 21 0.0 1.0 1.0
Competing endogenous rnas cernas regulate pten translation 0 8 0.0 1.0 1.0
Collagen chain trimerization 0 13 0.0 1.0 1.0
Regulation of pten gene transcription 0 56 0.0 1.0 1.0
Regulation of pten mrna translation 0 9 0.0 1.0 1.0
Runx3 regulates notch signaling 0 11 0.0 1.0 1.0
Runx3 regulates cdkn1a transcription 0 7 0.0 1.0 1.0
Runx1 interacts with co factors whose precise effect on runx1 targets is not known 2 36 2.3706360593017695 0.21793566077271245 1.0 P19784,Q13951
Esr mediated signaling 4 136 1.2190760059612518 0.42267663007615675 1.0 P12931,P63096,Q13951,Q99873
Regulation of pten localization 0 8 0.0 1.0 1.0
Fatty acid metabolism 1 117 0.3431523104844339 0.9448514329328714 1.0 O43772
Metabolism of steroids 2 103 0.7926426789020365 0.7191221907733483 1.0 Q03426,Q15392
Phenylalanine and tyrosine metabolism 0 6 0.0 1.0 1.0
Lipid particle organization 0 1 0.0 1.0 1.0
Glutamate and glutamine metabolism 0 14 0.0 1.0 1.0
Phenylalanine metabolism 0 4 0.0 1.0 1.0
Hdl remodeling 0 3 0.0 1.0 1.0
Vldl clearance 0 4 0.0 1.0 1.0
Plasma lipoprotein clearance 0 23 0.0 1.0 1.0
Ldl remodeling 0 2 0.0 1.0 1.0
Ldl clearance 0 17 0.0 1.0 1.0
Tyrosine catabolism 0 2 0.0 1.0 1.0
Chylomicron clearance 0 4 0.0 1.0 1.0
Chylomicron remodeling 0 4 0.0 1.0 1.0
Plasma lipoprotein remodeling 0 12 0.0 1.0 1.0
Plasma lipoprotein assembly 0 12 0.0 1.0 1.0
Hdl assembly 0 6 0.0 1.0 1.0
Assembly of active lpl and lipc lipase complexes 0 7 0.0 1.0 1.0
Chylomicron assembly 0 5 0.0 1.0 1.0
Digestion and absorption 0 1 0.0 1.0 1.0
Aspartate and asparagine metabolism 0 7 0.0 1.0 1.0
Hdl clearance 0 2 0.0 1.0 1.0
Aurka activation by tpx2 3 73 1.727930029154519 0.26185347416192173 1.0 O75935,P04350,P07437
Activation of kainate receptors upon glutamate binding 1 16 2.6809716599190283 0.3258327648280404 1.0 Q01970
Tnfr1 induced nfkappab signaling pathway 0 28 0.0 1.0 1.0
Activation of trka receptors 0 1 0.0 1.0 1.0
Signaling by pdgf 2 35 2.442719881744272 0.20895917602195896 1.0 P12931,P46109
Regulation of beta cell development 0 22 0.0 1.0 1.0
Synthesis of ip3 and ip4 in the cytosol 1 20 2.1157042403579798 0.3891747515056749 1.0 Q01970
Synthesis of ip2 ip and ins in the cytosol 0 12 0.0 1.0 1.0
Synthesis of pyrophosphates in the cytosol 1 10 4.470985155195682 0.21835116687336614 1.0 Q92551
Organelle biogenesis and maintenance 9 268 1.4087171451188187 0.20602712559827868 1.0 O00471,O60645,O75935,P04350,P07437,P11474,Q8IW35,Q96FJ2,Q9Y547
Fgfr2 mutant receptor activation 0 18 0.0 1.0 1.0
Ngf independant trka activation 0 1 0.0 1.0 1.0
Fgfr1 mutant receptor activation 0 22 0.0 1.0 1.0
Cytosolic sensors of pathogen associated dna 0 56 0.0 1.0 1.0
Sting mediated induction of host immune responses 0 10 0.0 1.0 1.0
Egfr downregulation 0 22 0.0 1.0 1.0
Nef mediated cd8 down regulation 0 6 0.0 1.0 1.0
Acetylcholine binding and downstream events 0 2 0.0 1.0 1.0
Norepinephrine neurotransmitter release cycle 0 12 0.0 1.0 1.0
Serotonin neurotransmitter release cycle 0 14 0.0 1.0 1.0
Rip mediated nfkb activation via zbp1 0 16 0.0 1.0 1.0
Signaling by cytosolic fgfr1 fusion mutants 0 18 0.0 1.0 1.0
Signalling to p38 via rit and rin 0 3 0.0 1.0 1.0
Cellular hexose transport 0 6 0.0 1.0 1.0
Metabolism of porphyrins 0 17 0.0 1.0 1.0
Estrogen biosynthesis 0 2 0.0 1.0 1.0
Androgen biosynthesis 0 2 0.0 1.0 1.0
Synthesis of bile acids and bile salts 0 20 0.0 1.0 1.0
Pre notch expression and processing 1 50 0.8178963893249608 0.7089333658266467 1.0 Q9H488
Pre notch processing in golgi 0 13 0.0 1.0 1.0
Gap junction degradation 0 12 0.0 1.0 1.0
Transport of connexons to the plasma membrane 1 14 3.094051697290564 0.2917500038862815 1.0 P04350
Gap junction assembly 1 15 2.8727588201272414 0.30900064216985557 1.0 P04350
Fgfr2b ligand binding and activation 0 2 0.0 1.0 1.0
Fgfr2c ligand binding and activation 0 2 0.0 1.0 1.0
Fgfr1c ligand binding and activation 0 2 0.0 1.0 1.0
Fgfr3b ligand binding and activation 0 1 0.0 1.0 1.0
Fgfr1b ligand binding and activation 0 2 0.0 1.0 1.0
Fgfr1 ligand binding and activation 0 2 0.0 1.0 1.0
Fgfr2 ligand binding and activation 0 2 0.0 1.0 1.0
Fgfr3 ligand binding and activation 0 3 0.0 1.0 1.0
Signaling by fgfr 1 57 0.7151532677848468 0.755241359516926 1.0 P12931
Heme degradation 0 7 0.0 1.0 1.0
Heme biosynthesis 0 12 0.0 1.0 1.0
Nuclear import of rev protein 1 34 1.216415163783585 0.5676800659750835 1.0 P55735
Apobec3g mediated resistance to hiv 1 infection 0 4 0.0 1.0 1.0
Shc1 events in egfr signaling 0 7 0.0 1.0 1.0
Gab1 signalosome 1 10 4.470985155195682 0.21835116687336614 1.0 P12931
Regulation of glucokinase by glucokinase regulatory protein 1 31 1.3384615384615384 0.534424974066877 1.0 P55735
Adenylate cyclase activating pathway 0 3 0.0 1.0 1.0
Prolonged erk activation events 1 12 3.6573426573426575 0.25595147351442515 1.0 P46109
Ddx58 ifih1 mediated induction of interferon alpha beta 1 57 0.7151532677848468 0.755241359516926 1.0 Q15366
Ticam1 rip1 mediated ikk complex recruitment 0 16 0.0 1.0 1.0
Toll like receptor cascades 3 103 1.205877551020408 0.4597705717809929 1.0 P30154,P63208,Q6SZW1
Neurotoxicity of clostridium toxins 0 8 0.0 1.0 1.0
Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 2 42 2.013821138211382 0.27225579108735287 1.0 P42575,Q9Y2Z0
Nod1 2 signaling pathway 1 30 1.3847549909255898 0.5227832512917782 1.0 P42575
Viral messenger rna synthesis 1 44 0.9325863854627624 0.6623596340642164 1.0 P55735
Ns1 mediated effects on host pathways 2 40 2.120239623448866 0.25410353757262955 1.0 P52294,P55735
Export of viral ribonucleoproteins from nucleus 1 32 1.2951547603500064 0.5457838138498524 1.0 P55735
Toll like receptor tlr1 tlr2 cascade 2 70 1.1812529890004781 0.5109892685584014 1.0 P30154,P63208
Toll like receptor 9 tlr9 cascade 2 75 1.0997883951442253 0.5482061693138647 1.0 P30154,P63208
Trafficking and processing of endosomal tlr 0 8 0.0 1.0 1.0
The fatty acid cycling model 0 1 0.0 1.0 1.0
Nef mediated cd4 down regulation 0 7 0.0 1.0 1.0
Hiv elongation arrest and recovery 0 32 0.0 1.0 1.0
Abortive elongation of hiv 1 transcript in the absence of tat 0 23 0.0 1.0 1.0
Signaling by tgf beta receptor complex 1 67 0.6061832903938167 0.8089528954045491 1.0 P62942
Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol 0 13 0.0 1.0 1.0
Arms mediated activation 0 5 0.0 1.0 1.0
Telomere extension by telomerase 0 21 0.0 1.0 1.0
Darpp 32 events 1 20 2.1157042403579798 0.3891747515056749 1.0 P30154
Apc cdc20 mediated degradation of nek2a 0 25 0.0 1.0 1.0
Chondroitin sulfate dermatan sulfate metabolism 0 32 0.0 1.0 1.0
Signaling by egfr 1 40 1.028651510432887 0.6272586592143582 1.0 P12931
Retrograde neurotrophin signalling 0 12 0.0 1.0 1.0
Interactions of rev with host cellular proteins 1 37 1.114709851551957 0.5985687060361295 1.0 P55735
Unwinding of dna 0 12 0.0 1.0 1.0
Phosphorylation of emi1 0 6 0.0 1.0 1.0
Phosphorylation of the apc c 0 20 0.0 1.0 1.0
Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0 20 0.0 1.0 1.0
Interactions of vpr with host cellular proteins 2 37 2.30267131242741 0.22694506266550968 1.0 P52294,P55735
Assembly of the hiv virion 1 15 2.8727588201272414 0.30900064216985557 1.0 Q99816
Plasma lipoprotein assembly remodeling and clearance 0 40 0.0 1.0 1.0
Activation of c3 and c5 0 1 0.0 1.0 1.0
Telomere c strand synthesis initiation 1 13 3.3522267206477734 0.2740704871267072 1.0 P49643
Glutathione synthesis and recycling 0 8 0.0 1.0 1.0
Transport and synthesis of paps 0 4 0.0 1.0 1.0
Apc c cdc20 mediated degradation of cyclin b 0 23 0.0 1.0 1.0
Alternative complement activation 0 1 0.0 1.0 1.0
P38mapk events 1 13 3.3522267206477734 0.2740704871267072 1.0 P12931
Transcription of the hiv genome 0 67 0.0 1.0 1.0
P75ntr signals via nf kb 0 14 0.0 1.0 1.0
P75ntr negatively regulates cell cycle via sc1 0 5 0.0 1.0 1.0
Microrna mirna biogenesis 1 24 1.7470515754268614 0.44658711947191027 1.0 Q9UPY3
Nostrin mediated enos trafficking 0 3 0.0 1.0 1.0
Enos activation 0 7 0.0 1.0 1.0
Yap1 and wwtr1 taz stimulated gene expression 0 10 0.0 1.0 1.0
Role of phospholipids in phagocytosis 0 16 0.0 1.0 1.0
Fcgamma receptor fcgr dependent phagocytosis 3 72 1.7531499556344277 0.25527235559725436 1.0 O15145,P12931,Q9Y6W5
Signaling by hippo 0 21 0.0 1.0 1.0
Cell surface interactions at the vascular wall 2 70 1.1812529890004781 0.5109892685584014 1.0 P12931,P14174
Regulation of pyruvate dehydrogenase pdh complex 0 16 0.0 1.0 1.0
Erks are inactivated 1 11 4.0234817813765185 0.2373820829012167 1.0 P30154
Generation of second messenger molecules 0 11 0.0 1.0 1.0
Cs ds degradation 0 7 0.0 1.0 1.0
Hs gag degradation 0 17 0.0 1.0 1.0
Hs gag biosynthesis 0 17 0.0 1.0 1.0
Dermatan sulfate biosynthesis 0 6 0.0 1.0 1.0
Chondroitin sulfate biosynthesis 0 12 0.0 1.0 1.0
Keratan sulfate degradation 0 6 0.0 1.0 1.0
Keratan sulfate biosynthesis 0 11 0.0 1.0 1.0
Calcineurin activates nfat 1 8 5.749566223250434 0.17885878423025256 1.0 P62942
Alpha linolenic omega3 and linoleic omega6 acid metabolism 0 12 0.0 1.0 1.0
Linoleic acid la metabolism 0 7 0.0 1.0 1.0
Cell death signalling via nrage nrif and nade 1 63 0.6455530886770275 0.7890437536081039 1.0 P42575
Xenobiotics 0 4 0.0 1.0 1.0
Eicosanoids 0 1 0.0 1.0 1.0
Endogenous sterols 0 12 0.0 1.0 1.0
Miscellaneous substrates 0 2 0.0 1.0 1.0
Phase i functionalization of compounds 0 39 0.0 1.0 1.0
Cytochrome p450 arranged by substrate type 0 15 0.0 1.0 1.0
Biological oxidations 4 94 1.7956284153005464 0.19539020832021228 1.0 P21266,P78417,Q96IU4,Q9UI30
Gene silencing by rna 2 75 1.0997883951442253 0.5482061693138647 1.0 P55735,Q9UPY3
Tie2 signaling 0 12 0.0 1.0 1.0
Basigin interactions 0 16 0.0 1.0 1.0
Pecam1 interactions 1 9 5.030364372469635 0.1988473022417859 1.0 P12931
Regulation of gene expression in early pancreatic precursor cells 0 3 0.0 1.0 1.0
Regulation of gene expression in beta cells 0 12 0.0 1.0 1.0
Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells 0 10 0.0 1.0 1.0
Glutamate neurotransmitter release cycle 0 17 0.0 1.0 1.0
Metabolism of amine derived hormones 0 1 0.0 1.0 1.0
Nf kb is activated and signals survival 0 11 0.0 1.0 1.0
P75ntr recruits signalling complexes 0 11 0.0 1.0 1.0
Nrif signals cell death from the nucleus 0 14 0.0 1.0 1.0
Metabolism of angiotensinogen to angiotensins 0 8 0.0 1.0 1.0
Assembly of collagen fibrils and other multimeric structures 0 28 0.0 1.0 1.0
Metabolism of nitric oxide nos3 activation and regulation 0 10 0.0 1.0 1.0
G protein activation 0 13 0.0 1.0 1.0
Nicotinate metabolism 0 18 0.0 1.0 1.0
Vitamin d calciferol metabolism 0 8 0.0 1.0 1.0
Coenzyme a biosynthesis 0 8 0.0 1.0 1.0
Biotin transport and metabolism 0 11 0.0 1.0 1.0
Metabolism of folate and pterines 0 15 0.0 1.0 1.0
Cobalamin cbl vitamin b12 transport and metabolism 0 13 0.0 1.0 1.0
Pi3k events in erbb2 signaling 0 7 0.0 1.0 1.0
Grb2 events in erbb2 signaling 0 7 0.0 1.0 1.0
Beta catenin phosphorylation cascade 1 16 2.6809716599190283 0.3258327648280404 1.0 P30154
Pregnenolone biosynthesis 0 8 0.0 1.0 1.0
Metabolism of steroid hormones 0 12 0.0 1.0 1.0
Vegf ligand receptor interactions 0 2 0.0 1.0 1.0
Signaling by vegf 2 87 0.94337637494022 0.6292234985975467 1.0 P12931,Q9Y6W5
Bile acid and bile salt metabolism 0 22 0.0 1.0 1.0
Synthesis of bile acids and bile salts via 27 hydroxycholesterol 0 7 0.0 1.0 1.0
Synthesis of bile acids and bile salts via 24 hydroxycholesterol 0 5 0.0 1.0 1.0
P75 ntr receptor mediated signalling 1 81 0.4993927125506073 0.8650033356775808 1.0 P42575
P75ntr regulates axonogenesis 0 5 0.0 1.0 1.0
Regulated proteolysis of p75ntr 0 11 0.0 1.0 1.0
Vitamin b1 thiamin metabolism 0 5 0.0 1.0 1.0
Nrage signals death through jnk 0 47 0.0 1.0 1.0
Vitamin b2 riboflavin metabolism 0 4 0.0 1.0 1.0
Metabolism of vitamins and cofactors 4 134 1.2380832282471628 0.41170754353552386 1.0 O00764,P78417,Q5T2R2,Q96EN8
Formation of the beta catenin tcf transactivating complex 1 38 1.084473137104716 0.6083683872182535 1.0 Q9UBL3
Wnt mediated activation of dvl 1 8 5.749566223250434 0.17885878423025256 1.0 P19784
Signaling by alk 1 19 2.233468286099865 0.373917962138579 1.0 P12931
Signaling by bmp 0 15 0.0 1.0 1.0
Carnitine metabolism 1 12 3.6573426573426575 0.25595147351442515 1.0 O43772
Trans golgi network vesicle budding 2 69 1.199004975124378 0.5033091484792607 1.0 O00161,Q13492
Creb phosphorylation 0 7 0.0 1.0 1.0
Negative regulation of the pi3k akt network 2 62 1.3398373983739837 0.447448107055433 1.0 P12931,P30154
Vitamin b5 pantothenate metabolism 0 13 0.0 1.0 1.0
Immunoregulatory interactions between a lymphoid and a non lymphoid cell 0 26 0.0 1.0 1.0
Erk mapk targets 1 20 2.1157042403579798 0.3891747515056749 1.0 P30154
Nuclear events kinase and transcription factor activation 1 42 0.9782758961192851 0.6452412597701435 1.0 P30154
Akt phosphorylates targets in the nucleus 0 9 0.0 1.0 1.0
Akt phosphorylates targets in the cytosol 1 14 3.094051697290564 0.2917500038862815 1.0 Q96B36
Pi3k akt activation 0 7 0.0 1.0 1.0
Signaling by notch2 0 22 0.0 1.0 1.0
Signaling by notch1 1 56 0.7282296650717703 0.74910507331705 1.0 P63208
Nicotinamide salvaging 0 11 0.0 1.0 1.0
A tetrasaccharide linker sequence is required for gag synthesis 0 16 0.0 1.0 1.0
Metabolism of water soluble vitamins and cofactors 3 91 1.3719851576994435 0.38180624229540333 1.0 O00764,P78417,Q96EN8
Cyp2e1 reactions 0 1 0.0 1.0 1.0
Hiv transcription elongation 0 42 0.0 1.0 1.0
Signalling to ras 1 16 2.6809716599190283 0.3258327648280404 1.0 P12931
Inwardly rectifying k channels 0 12 0.0 1.0 1.0
Spry regulation of fgf signaling 1 14 3.094051697290564 0.2917500038862815 1.0 P12931
Mitochondrial protein import 0 59 0.0 1.0 1.0
Interleukin 7 signaling 0 13 0.0 1.0 1.0
Nuclear signaling by erbb4 1 18 2.3650869254584426 0.3582816735878424 1.0 P12931
Shc1 events in erbb4 signaling 0 6 0.0 1.0 1.0
Pi3k events in erbb4 signaling 0 2 0.0 1.0 1.0
Shc1 events in erbb2 signaling 0 13 0.0 1.0 1.0
Potassium channels 0 15 0.0 1.0 1.0
Erythrocytes take up oxygen and release carbon dioxide 0 1 0.0 1.0 1.0
Erythrocytes take up carbon dioxide and release oxygen 0 4 0.0 1.0 1.0
Endosomal vacuolar pathway 0 10 0.0 1.0 1.0
Cross presentation of particulate exogenous antigens phagosomes 0 3 0.0 1.0 1.0
Signaling by erbb4 1 36 1.1466743782533255 0.5885248237912099 1.0 P12931
Constitutive signaling by ligand responsive egfr cancer variants 0 17 0.0 1.0 1.0
Regulation of gene expression by hypoxia inducible factor 0 5 0.0 1.0 1.0
Signaling by erbb2 in cancer 0 17 0.0 1.0 1.0
Signaling by erbb2 1 37 1.114709851551957 0.5985687060361295 1.0 P12931
Methionine salvage pathway 0 6 0.0 1.0 1.0
Voltage gated potassium channels 0 2 0.0 1.0 1.0
Tandem pore domain potassium channels 0 2 0.0 1.0 1.0
Sperm motility and taxes 0 1 0.0 1.0 1.0
Signaling by scf kit 1 31 1.3384615384615384 0.534424974066877 1.0 P12931
The citric acid tca cycle and respiratory electron transport 1 160 0.24925521350546176 0.9811504634225037 1.0 Q9UDW1
Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components 0 21 0.0 1.0 1.0
Formation of fibrin clot clotting cascade 0 9 0.0 1.0 1.0
Common pathway of fibrin clot formation 0 5 0.0 1.0 1.0
Intrinsic pathway of fibrin clot formation 0 7 0.0 1.0 1.0
Extrinsic pathway of fibrin clot formation 0 1 0.0 1.0 1.0
Caspase activation via death receptors in the presence of ligand 0 11 0.0 1.0 1.0
Activation of puma and translocation to mitochondria 0 8 0.0 1.0 1.0
Elevation of cytosolic ca2 levels 0 6 0.0 1.0 1.0
Abc transporters in lipid homeostasis 0 7 0.0 1.0 1.0
Bmal1 clock npas2 activates circadian gene expression 0 20 0.0 1.0 1.0
Rora activates gene expression 0 17 0.0 1.0 1.0
Mitochondrial iron sulfur cluster biogenesis 0 12 0.0 1.0 1.0
Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1 0 16 0.0 1.0 1.0
Transcription of e2f targets under negative control by dream complex 0 19 0.0 1.0 1.0
Downregulation of erbb2 erbb3 signaling 0 10 0.0 1.0 1.0
Grb7 events in erbb2 signaling 0 2 0.0 1.0 1.0
Acrosome reaction and sperm oocyte membrane binding 0 1 0.0 1.0 1.0
Signaling by fgfr in disease 0 48 0.0 1.0 1.0
Ros and rns production in phagocytes 0 16 0.0 1.0 1.0
Meiotic synapsis 0 31 0.0 1.0 1.0
Fertilization 0 3 0.0 1.0 1.0
Ca dependent events 0 26 0.0 1.0 1.0
Camk iv mediated phosphorylation of creb 0 8 0.0 1.0 1.0
Pka mediated phosphorylation of creb 0 13 0.0 1.0 1.0
Opioid signalling 3 63 2.0179591836734696 0.19744384534818976 1.0 P30154,P63096,Q01970
Apoptotic factor mediated response 1 20 2.1157042403579798 0.3891747515056749 1.0 O14727
Smac xiap regulated apoptotic response 1 8 5.749566223250434 0.17885878423025256 1.0 O14727
Apoptotic cleavage of cellular proteins 1 35 1.1805191712312455 0.5782306803788487 1.0 P55212
Cytochrome c mediated apoptotic response 1 13 3.3522267206477734 0.2740704871267072 1.0 O14727
Formation of apoptosome 1 11 4.0234817813765185 0.2373820829012167 1.0 O14727
Release of apoptotic factors from the mitochondria 0 6 0.0 1.0 1.0
Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members 0 8 0.0 1.0 1.0
Activation of noxa and translocation to mitochondria 0 5 0.0 1.0 1.0
Activation of bad and translocation to mitochondria 0 16 0.0 1.0 1.0
Displacement of dna glycosylase by apex1 1 8 5.749566223250434 0.17885878423025256 1.0 P27695
Recognition and association of dna glycosylase with site containing an affected purine 0 16 0.0 1.0 1.0
Translesion synthesis by y family dna polymerases bypasses lesions on dna template 2 41 2.0656660412757972 0.26317889352468227 1.0 P35244,P35250
Mapk3 erk1 activation 0 8 0.0 1.0 1.0
Intrinsic pathway for apoptosis 2 53 1.577714012434242 0.37082744740103835 1.0 O14727,Q96FJ2
Hemostasis 9 361 1.0265785469760365 0.5182790213087032 1.0 P04350,P12931,P14174,P23634,P30154,P47755,P63096,Q8IWA4,Q9NUQ9
G protein mediated events 2 40 2.120239623448866 0.25410353757262955 1.0 P63096,Q01970
Regulation of kit signaling 1 12 3.6573426573426575 0.25595147351442515 1.0 P12931
Electric transmission across gap junctions 0 2 0.0 1.0 1.0
Neurotransmitter release cycle 0 30 0.0 1.0 1.0
Signaling by nodal 0 12 0.0 1.0 1.0
Prolactin receptor signaling 1 9 5.030364372469635 0.1988473022417859 1.0 P63208
Antiviral mechanism by ifn stimulated genes 2 73 1.1309973663116912 0.5335587935482642 1.0 P52294,P55735
Activation of ras in b cells 0 3 0.0 1.0 1.0
Gpvi mediated activation cascade 0 21 0.0 1.0 1.0
Disinhibition of snare formation 0 4 0.0 1.0 1.0
Effects of pip2 hydrolysis 0 17 0.0 1.0 1.0
Activation of bh3 only proteins 1 29 1.434355118565645 0.510851629797044 1.0 Q96FJ2
E2f enabled inhibition of pre replication complex formation 1 10 4.470985155195682 0.21835116687336614 1.0 O43929
Formation of the early elongation complex 0 33 0.0 1.0 1.0
Sos mediated signalling 0 7 0.0 1.0 1.0
Mapk1 erk2 activation 0 7 0.0 1.0 1.0
Raf independent mapk1 3 activation 1 15 2.8727588201272414 0.30900064216985557 1.0 Q99956
Irs mediated signalling 0 26 0.0 1.0 1.0
Formation of rna pol ii elongation complex 0 58 0.0 1.0 1.0
Neuronal system 5 177 1.1694899033400326 0.4317704814819689 1.0 O95197,P04350,P12931,P63096,Q01970
Transmission across chemical synapses 4 139 1.1916211293260475 0.43903584243069105 1.0 P04350,P12931,P63096,Q01970
Neurotransmitter receptors and postsynaptic signal transmission 4 105 1.5982795000811556 0.2522746634689108 1.0 P04350,P12931,P63096,Q01970
Neurotransmitter clearance 0 3 0.0 1.0 1.0
Presynaptic depolarization and calcium channel opening 0 4 0.0 1.0 1.0
Hiv transcription initiation 0 45 0.0 1.0 1.0
Regulation of signaling by nodal 0 3 0.0 1.0 1.0
Defensins 0 1 0.0 1.0 1.0
Heparan sulfate heparin hs gag metabolism 0 32 0.0 1.0 1.0
Keratan sulfate keratin metabolism 0 17 0.0 1.0 1.0
Chrebp activates metabolic gene expression 0 8 0.0 1.0 1.0
Integration of energy metabolism 3 71 1.7791116446578632 0.24871536728792598 1.0 P30154,P63096,Q01970
Ampk inhibits chrebp transcriptional activation activity 0 7 0.0 1.0 1.0
Triglyceride catabolism 0 13 0.0 1.0 1.0
Glucagon signaling in metabolic regulation 0 21 0.0 1.0 1.0
Pka mediated phosphorylation of key metabolic factors 0 4 0.0 1.0 1.0
Gamma carboxylation hypusine formation and arylsulfatase activation 1 29 1.434355118565645 0.510851629797044 1.0 Q9H2P9
Formation of atp by chemiosmotic coupling 0 14 0.0 1.0 1.0
Post translational modification synthesis of gpi anchored proteins 0 32 0.0 1.0 1.0
Glycosaminoglycan metabolism 0 70 0.0 1.0 1.0
Attachment of gpi anchor to upar 0 7 0.0 1.0 1.0
Synthesis of glycosylphosphatidylinositol gpi 0 12 0.0 1.0 1.0
Golgi cisternae pericentriolar stack reorganization 0 14 0.0 1.0 1.0
Integration of provirus 1 9 5.030364372469635 0.1988473022417859 1.0 P52294
Budding and maturation of hiv virion 1 27 1.5450015571473061 0.48608975697343193 1.0 Q99816
Hiv life cycle 4 144 1.1484777517564402 0.46599279188887915 1.0 P39748,P52294,P55735,Q99816
Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 1 116 0.34617144868861116 0.9434603787570304 1.0 Q9UDW1
Signaling by egfr in cancer 0 17 0.0 1.0 1.0
Pka activation in glucagon signalling 0 12 0.0 1.0 1.0
2 ltr circle formation 0 7 0.0 1.0 1.0
Terminal pathway of complement 0 1 0.0 1.0 1.0
Initial triggering of complement 0 1 0.0 1.0 1.0
Complement cascade 0 10 0.0 1.0 1.0
Signaling by ntrks 3 102 1.2181818181818183 0.45341784496631077 1.0 P12931,P30154,P46109
The activation of arylsulfatases 0 8 0.0 1.0 1.0
Mitochondrial uncoupling 0 1 0.0 1.0 1.0
Myd88 independent tlr4 cascade 3 78 1.6119183673469388 0.2950347285537182 1.0 P30154,P63208,Q6SZW1
Glycosphingolipid metabolism 0 33 0.0 1.0 1.0
Sphingolipid de novo biosynthesis 0 29 0.0 1.0 1.0
Synthesis of pips at the late endosome membrane 1 10 4.470985155195682 0.21835116687336614 1.0 Q13614
Synthesis of pips at the early endosome membrane 1 16 2.6809716599190283 0.3258327648280404 1.0 Q13614
Synthesis of pips at the golgi membrane 0 15 0.0 1.0 1.0
Synthesis of pips at the plasma membrane 1 47 0.871501496215455 0.6865067343299582 1.0 Q13614
Regulation of cholesterol biosynthesis by srebp srebf 1 55 0.7417903733693207 0.7428155815810851 1.0 Q03426
Collagen biosynthesis and modifying enzymes 0 30 0.0 1.0 1.0
The role of nef in hiv 1 replication and disease pathogenesis 0 20 0.0 1.0 1.0
Nef and signal transduction 0 4 0.0 1.0 1.0
Nef mediated downregulation of mhc class i complex cell surface expression 0 9 0.0 1.0 1.0
Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 0 16 0.0 1.0 1.0
Sulfur amino acid metabolism 0 22 0.0 1.0 1.0
Degradation of cysteine and homocysteine 0 12 0.0 1.0 1.0
Sulfide oxidation to sulfate 0 5 0.0 1.0 1.0
Irf3 mediated activation of type 1 ifn 0 3 0.0 1.0 1.0
Glycerophospholipid biosynthesis 1 86 0.46977851869492737 0.8807637117797447 1.0 P19784
Synthesis of pc 1 22 1.913823019086177 0.4185863086244521 1.0 P19784
Synthesis of pa 0 25 0.0 1.0 1.0
Synthesis of pg 0 8 0.0 1.0 1.0
Hydrolysis of lpc 0 3 0.0 1.0 1.0
Acyl chain remodelling of pg 0 7 0.0 1.0 1.0
Acyl chain remodelling of pi 0 4 0.0 1.0 1.0
Acyl chain remodeling of dag and tag 0 2 0.0 1.0 1.0
Acyl chain remodelling of pe 0 8 0.0 1.0 1.0
Acyl chain remodelling of ps 0 9 0.0 1.0 1.0
Acyl chain remodeling of cl 0 5 0.0 1.0 1.0
Acyl chain remodelling of pc 0 9 0.0 1.0 1.0
Reversible hydration of carbon dioxide 0 2 0.0 1.0 1.0
Collagen formation 0 44 0.0 1.0 1.0
Extracellular matrix organization 0 131 0.0 1.0 1.0
Degradation of the extracellular matrix 0 56 0.0 1.0 1.0
Reproduction 1 57 0.7151532677848468 0.755241359516926 1.0 P35244
Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation 0 7 0.0 1.0 1.0
Alpha defensins 0 1 0.0 1.0 1.0
Synthesis of pe 0 12 0.0 1.0 1.0
Collagen degradation 0 21 0.0 1.0 1.0
Synthesis of pi 0 5 0.0 1.0 1.0
Pi metabolism 1 71 0.5713128976286871 0.8269899568539123 1.0 Q13614
Zbp1 dai mediated induction of type i ifns 0 18 0.0 1.0 1.0
Gamma carboxylation transport and amino terminal cleavage of proteins 0 5 0.0 1.0 1.0
Removal of aminoterminal propeptides from gamma carboxylated proteins 0 4 0.0 1.0 1.0
Recycling of bile acids and salts 0 6 0.0 1.0 1.0
Activation of matrix metalloproteinases 0 6 0.0 1.0 1.0
Transport of mature mrnas derived from intronless transcripts 1 43 0.9548872180451128 0.6539058419658339 1.0 P55735
Transport of the slbp dependant mature mrna 1 36 1.1466743782533255 0.5885248237912099 1.0 P55735
Mitochondrial biogenesis 1 85 0.47541931752458066 0.8777655773752524 1.0 P11474
Polo like kinase mediated events 0 16 0.0 1.0 1.0
Fibronectin matrix formation 0 3 0.0 1.0 1.0
Elastic fibre formation 0 23 0.0 1.0 1.0
Glucuronidation 0 4 0.0 1.0 1.0
Cytosolic sulfonation of small molecules 1 14 3.094051697290564 0.2917500038862815 1.0 Q96IU4
G0 and early g1 0 26 0.0 1.0 1.0
Signaling by activin 0 9 0.0 1.0 1.0
Cell cell communication 2 79 1.042234188575652 0.5765263512781815 1.0 P12931,Q15404
Meiosis 1 54 0.7558628065082882 0.7363690750519482 1.0 P35244
Dag and ip3 signaling 0 30 0.0 1.0 1.0
Phospholipid metabolism 2 156 0.5170520536374195 0.8968635215689711 1.0 P19784,Q13614
Inositol phosphate metabolism 2 40 2.120239623448866 0.25410353757262955 1.0 Q01970,Q92551
Synthesis of diphthamide eef2 1 8 5.749566223250434 0.17885878423025256 1.0 Q9H2P9
Epigenetic regulation of gene expression 0 102 0.0 1.0 1.0
Activated notch1 transmits signal to the nucleus 0 21 0.0 1.0 1.0
Bicarbonate transporters 0 4 0.0 1.0 1.0
Transport of bile salts and organic acids metal ions and amine compounds 0 32 0.0 1.0 1.0
Regulation of insulin secretion 2 48 1.7500883704489218 0.3264636262265684 1.0 P63096,Q01970
Synthesis secretion and deacylation of ghrelin 0 5 0.0 1.0 1.0
Cell cell junction organization 0 31 0.0 1.0 1.0
Nectin necl trans heterodimerization 0 5 0.0 1.0 1.0
Glucagon type ligand receptors 0 13 0.0 1.0 1.0
Tight junction interactions 0 11 0.0 1.0 1.0
Transport of inorganic cations anions and amino acids oligopeptides 0 44 0.0 1.0 1.0
Lysosphingolipid and lpa receptors 0 3 0.0 1.0 1.0
Adherens junctions interactions 0 18 0.0 1.0 1.0
Role of second messengers in netrin 1 signaling 0 3 0.0 1.0 1.0
Caspase activation via dependence receptors in the absence of ligand 0 7 0.0 1.0 1.0
Dcc mediated attractive signaling 1 13 3.3522267206477734 0.2740704871267072 1.0 P12931
G alpha z signalling events 1 28 1.4876293297345928 0.4986229205358068 1.0 P63096
Adp signalling through p2y purinoceptor 1 1 17 2.513157894736842 0.3422564852890665 1.0 P12931
G alpha s signalling events 2 37 2.30267131242741 0.22694506266550968 1.0 P12931,P63096
Cgmp effects 0 7 0.0 1.0 1.0
Ncam1 interactions 0 15 0.0 1.0 1.0
Transport of vitamins nucleosides and related molecules 0 21 0.0 1.0 1.0
Slc mediated transmembrane transport 0 101 0.0 1.0 1.0
Metal ion slc transporters 0 15 0.0 1.0 1.0
Mrna decay by 5 to 3 exoribonuclease 0 15 0.0 1.0 1.0
Mrna decay by 3 to 5 exoribonuclease 0 16 0.0 1.0 1.0
Deadenylation of mrna 1 26 1.6069635627530365 0.47324459065334146 1.0 Q9UIV1
Deadenylation dependent mrna decay 1 57 0.7151532677848468 0.755241359516926 1.0 Q9UIV1
Thromboxane signalling through tp receptor 0 15 0.0 1.0 1.0
Role of abl in robo slit signaling 0 9 0.0 1.0 1.0
Organic anion transporters 0 3 0.0 1.0 1.0
Inactivation of cdc42 and rac1 0 8 0.0 1.0 1.0
Activation of rac1 0 12 0.0 1.0 1.0
Sphingolipid metabolism 0 62 0.0 1.0 1.0
Sodium coupled phosphate cotransporters 0 2 0.0 1.0 1.0
Multifunctional anion exchangers 0 3 0.0 1.0 1.0
Ercc6 csb and ehmt2 g9a positively regulate rrna expression 0 27 0.0 1.0 1.0
Sirt1 negatively regulates rrna expression 0 18 0.0 1.0 1.0
Small interfering rna sirna biogenesis 1 9 5.030364372469635 0.1988473022417859 1.0 Q9UPY3
Cation coupled chloride cotransporters 0 4 0.0 1.0 1.0
Arachidonate production from dag 0 4 0.0 1.0 1.0
Sodium proton exchangers 0 4 0.0 1.0 1.0
Sodium calcium exchangers 0 3 0.0 1.0 1.0
Platelet calcium homeostasis 1 13 3.3522267206477734 0.2740704871267072 1.0 P23634
Platelet homeostasis 2 51 1.6424423427907748 0.3532043826100663 1.0 P23634,P30154
Nucleotide like purinergic receptors 0 1 0.0 1.0 1.0
P2y receptors 0 1 0.0 1.0 1.0
Muscle contraction 1 83 0.48711365656166683 0.8715422116736027 1.0 P23634
Eph ephrin mediated repulsion of cells 1 43 0.9548872180451128 0.6539058419658339 1.0 P12931
Ephrin signaling 1 17 2.513157894736842 0.3422564852890665 1.0 P12931
Epha mediated growth cone collapse 1 23 1.826647037173353 0.43275876738054964 1.0 P12931
Ephb mediated forward signaling 2 40 2.120239623448866 0.25410353757262955 1.0 O15145,P12931
Prostacyclin signalling through prostacyclin receptor 0 12 0.0 1.0 1.0
Rap1 signalling 0 13 0.0 1.0 1.0
G beta gamma signalling through pi3kgamma 0 15 0.0 1.0 1.0
Adp signalling through p2y purinoceptor 12 1 13 3.3522267206477734 0.2740704871267072 1.0 P63096
Nitric oxide stimulates guanylate cyclase 0 11 0.0 1.0 1.0
Signal regulatory protein family interactions 1 9 5.030364372469635 0.1988473022417859 1.0 P12931
Peroxisomal lipid metabolism 0 24 0.0 1.0 1.0
Diseases associated with o glycosylation of proteins 0 17 0.0 1.0 1.0
Striated muscle contraction 0 16 0.0 1.0 1.0
Association of tric cct with target proteins during biosynthesis 0 36 0.0 1.0 1.0
Folding of actin by cct tric 0 10 0.0 1.0 1.0
Beta oxidation of very long chain fatty acids 0 9 0.0 1.0 1.0
Formation of tubulin folding intermediates by cct tric 1 21 2.0097165991902832 0.4040612158985918 1.0 P04350
Pd 1 signaling 0 5 0.0 1.0 1.0
G protein beta gamma signalling 1 22 1.913823019086177 0.4185863086244521 1.0 Q01970
Vasopressin regulates renal water homeostasis via aquaporins 0 25 0.0 1.0 1.0
Trafficking of ampa receptors 0 20 0.0 1.0 1.0
Sema3a plexin repulsion signaling by inhibiting integrin adhesion 0 10 0.0 1.0 1.0
Trafficking of glur2 containing ampa receptors 0 11 0.0 1.0 1.0
Other semaphorin interactions 0 7 0.0 1.0 1.0
Sema4d induced cell migration and growth cone collapse 1 18 2.3650869254584426 0.3582816735878424 1.0 P08134
Sema4d mediated inhibition of cell attachment and migration 0 8 0.0 1.0 1.0
G alpha 12 13 signalling events 1 57 0.7151532677848468 0.755241359516926 1.0 P08134
G alpha q signalling events 1 66 0.6155714730613516 0.8041583515872358 1.0 Q01970
Sumoylation of intracellular receptors 0 18 0.0 1.0 1.0
Ca2 pathway 1 45 0.9112992270887008 0.6706077438596076 1.0 Q01970
Sumoylation of sumoylation proteins 1 35 1.1805191712312455 0.5782306803788487 1.0 P55735
Sialic acid metabolism 0 16 0.0 1.0 1.0
Sema4d in semaphorin signaling 1 23 1.826647037173353 0.43275876738054964 1.0 P08134
Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip 0 9 0.0 1.0 1.0
Incretin synthesis secretion and inactivation 0 14 0.0 1.0 1.0
Free fatty acids regulate insulin secretion 1 8 5.749566223250434 0.17885878423025256 1.0 Q01970
Circadian clock 1 55 0.7417903733693207 0.7428155815810851 1.0 P63208
Regulation of lipid metabolism by pparalpha 1 95 0.4244120940649496 0.9046558347203958 1.0 P11474
Adrenaline noradrenaline inhibits insulin secretion 1 16 2.6809716599190283 0.3258327648280404 1.0 P63096
Acetylcholine regulates insulin secretion 1 8 5.749566223250434 0.17885878423025256 1.0 Q01970
Crmps in sema3a signaling 0 12 0.0 1.0 1.0
Sema3a pak dependent axon repulsion 0 13 0.0 1.0 1.0
Sumoylation of transcription cofactors 1 41 1.002834008097166 0.6363606533565179 1.0 Q99497
Passive transport by aquaporins 0 1 0.0 1.0 1.0
Lysosome vesicle biogenesis 0 32 0.0 1.0 1.0
O linked glycosylation 0 35 0.0 1.0 1.0
Wnt5a dependent internalization of fzd2 fzd5 and ror2 0 12 0.0 1.0 1.0
Interleukin 3 interleukin 5 and gm csf signaling 1 31 1.3384615384615384 0.534424974066877 1.0 P46109
Wnt5a dependent internalization of fzd4 0 13 0.0 1.0 1.0
Defective c1galt1c1 causes tnps 0 2 0.0 1.0 1.0
Defective lfng causes scdo3 0 3 0.0 1.0 1.0
Defective galnt3 causes hftc 0 1 0.0 1.0 1.0
Gpcr ligand binding 1 46 0.8909581646423752 0.6786551558910596 1.0 Q9NRV9
O glycosylation of tsr domain containing proteins 0 5 0.0 1.0 1.0
Presynaptic function of kainate receptors 1 13 3.3522267206477734 0.2740704871267072 1.0 Q01970
Signaling by wnt in cancer 1 25 1.674089068825911 0.46007968674438166 1.0 P30154
Sumoylation of immune response proteins 0 10 0.0 1.0 1.0
Sumoylation of dna methylation proteins 0 16 0.0 1.0 1.0
Repression of wnt target genes 0 13 0.0 1.0 1.0
Regulation of fzd by ubiquitination 0 9 0.0 1.0 1.0
Disassembly of the destruction complex and recruitment of axin to the membrane 1 24 1.7470515754268614 0.44658711947191027 1.0 P30154
Sumoylation of dna replication proteins 1 46 0.8909581646423752 0.6786551558910596 1.0 P55735
Sumoylation of rna binding proteins 1 47 0.871501496215455 0.6865067343299582 1.0 P55735
Signaling by ctnnb1 phospho site mutants 1 15 2.8727588201272414 0.30900064216985557 1.0 P30154
Pink1 prkn mediated mitophagy 1 17 2.513157894736842 0.3422564852890665 1.0 Q8IWA4
Uptake and function of anthrax toxins 0 10 0.0 1.0 1.0
Ripk1 mediated regulated necrosis 0 26 0.0 1.0 1.0
Regulation of tnfr1 signaling 0 31 0.0 1.0 1.0
Tnfr1 induced proapoptotic signaling 0 13 0.0 1.0 1.0
Caspase activation via extrinsic apoptotic signalling pathway 0 18 0.0 1.0 1.0
Signaling by rnf43 mutants 0 4 0.0 1.0 1.0
Signaling by lrp5 mutants 0 2 0.0 1.0 1.0
Uptake and actions of bacterial toxins 0 23 0.0 1.0 1.0
Uptake and function of diphtheria toxin 0 5 0.0 1.0 1.0
Dna methylation 0 14 0.0 1.0 1.0
N glycan trimming in the er and calnexin calreticulin cycle 0 32 0.0 1.0 1.0
Diseases of immune system 0 15 0.0 1.0 1.0
Myogenesis 0 22 0.0 1.0 1.0
Toxicity of botulinum toxin type d botd 0 3 0.0 1.0 1.0
Negative epigenetic regulation of rrna expression 0 61 0.0 1.0 1.0
B wich complex positively regulates rrna expression 0 45 0.0 1.0 1.0
Positive epigenetic regulation of rrna expression 0 60 0.0 1.0 1.0
Miscellaneous transport and binding events 0 17 0.0 1.0 1.0
Vegfr2 mediated cell proliferation 1 15 2.8727588201272414 0.30900064216985557 1.0 P12931
Vegfr2 mediated vascular permeability 0 22 0.0 1.0 1.0
Regulated necrosis 0 42 0.0 1.0 1.0
Thrombin signalling through proteinase activated receptors pars 1 21 2.0097165991902832 0.4040612158985918 1.0 P12931
Sumoylation of chromatin organization proteins 1 58 0.702535691455359 0.7612281573002204 1.0 P55735
Transcriptional regulation of pluripotent stem cells 0 16 0.0 1.0 1.0
Interleukin 2 family signaling 0 21 0.0 1.0 1.0
Smooth muscle contraction 0 28 0.0 1.0 1.0
Signal transduction by l1 1 20 2.1157042403579798 0.3891747515056749 1.0 P19784
Interaction between l1 and ankyrins 0 12 0.0 1.0 1.0
Rsk activation 0 7 0.0 1.0 1.0
Ras activation upon ca2 influx through nmda receptor 0 13 0.0 1.0 1.0
Activation of nmda receptors and postsynaptic events 2 68 1.2172949002217295 0.4955518992738811 1.0 P04350,P12931
Creb1 phosphorylation through nmda receptor mediated activation of ras signaling 0 21 0.0 1.0 1.0
Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde 0 7 0.0 1.0 1.0
Creb1 phosphorylation through the activation of adenylate cyclase 0 9 0.0 1.0 1.0
Na cl dependent neurotransmitter transporters 0 4 0.0 1.0 1.0
Zinc influx into cells by the slc39 gene family 0 7 0.0 1.0 1.0
Depolymerisation of the nuclear lamina 0 16 0.0 1.0 1.0
Binding of tcf lef ctnnb1 to target gene promoters 0 7 0.0 1.0 1.0
Unblocking of nmda receptors glutamate binding and activation 0 9 0.0 1.0 1.0
Recycling pathway of l1 2 41 2.0656660412757972 0.26317889352468227 1.0 P04350,P12931
Zinc efflux and compartmentalization by the slc30 family 0 5 0.0 1.0 1.0
Zinc transporters 0 12 0.0 1.0 1.0
Proton coupled monocarboxylate transport 0 4 0.0 1.0 1.0
Golgi associated vesicle biogenesis 1 55 0.7417903733693207 0.7428155815810851 1.0 Q13492
Aquaporin mediated transport 0 26 0.0 1.0 1.0
Platelet sensitization by ldl 1 15 2.8727588201272414 0.30900064216985557 1.0 P30154
Tak1 activates nfkb by phosphorylation and activation of ikks complex 0 25 0.0 1.0 1.0
Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 3 59 2.1629737609329447 0.17288561353958642 1.0 O60547,Q86YN1,Q96EK6
Ionotropic activity of kainate receptors 0 3 0.0 1.0 1.0
Ksrp khsrp binds and destabilizes mrna 0 17 0.0 1.0 1.0
Hur elavl1 binds and stabilizes mrna 0 7 0.0 1.0 1.0
Tristetraprolin ttp zfp36 binds and destabilizes mrna 0 17 0.0 1.0 1.0
Butyrate response factor 1 brf1 binds and destabilizes mrna 0 17 0.0 1.0 1.0
Activation of the ap 1 family of transcription factors 0 8 0.0 1.0 1.0
Jnk c jun kinases phosphorylation and activation mediated by activated human tak1 0 18 0.0 1.0 1.0
Activated tak1 mediates p38 mapk activation 0 20 0.0 1.0 1.0
Mapk targets nuclear events mediated by map kinases 1 27 1.5450015571473061 0.48608975697343193 1.0 P30154
Other interleukin signaling 1 12 3.6573426573426575 0.25595147351442515 1.0 P40222
Interleukin 1 processing 0 3 0.0 1.0 1.0
Interleukin 17 signaling 2 57 1.462379896526238 0.40547304755941205 1.0 P30154,P63208
Neurofascin interactions 0 6 0.0 1.0 1.0
Chl1 interactions 0 7 0.0 1.0 1.0
Nrcam interactions 0 7 0.0 1.0 1.0
Cell junction organization 1 54 0.7558628065082882 0.7363690750519482 1.0 Q15404
Cell extracellular matrix interactions 1 16 2.6809716599190283 0.3258327648280404 1.0 Q15404
Synthesis of udp n acetyl glucosamine 1 8 5.749566223250434 0.17885878423025256 1.0 Q96EK6
Synthesis of gdp mannose 0 5 0.0 1.0 1.0
Type i hemidesmosome assembly 0 9 0.0 1.0 1.0
Notch1 intracellular domain regulates transcription 1 39 1.0558278286810143 0.6179297811879729 1.0 P63208
Beta oxidation of pristanoyl coa 0 7 0.0 1.0 1.0
Alpha oxidation of phytanate 0 6 0.0 1.0 1.0
Signaling by leptin 0 8 0.0 1.0 1.0
Cytosolic iron sulfur cluster assembly 1 13 3.3522267206477734 0.2740704871267072 1.0 O76071
Trif mediated programmed cell death 0 4 0.0 1.0 1.0
Dna damage telomere stress induced senescence 0 38 0.0 1.0 1.0
Oncogene induced senescence 1 30 1.3847549909255898 0.5227832512917782 1.0 Q00534
Formation of senescence associated heterochromatin foci sahf 0 15 0.0 1.0 1.0
Cellular senescence 1 131 0.3057614450327001 0.961099181377999 1.0 Q00534
Senescence associated secretory phenotype sasp 1 54 0.7558628065082882 0.7363690750519482 1.0 Q00534
Signaling by notch1 pest domain mutants in cancer 1 45 0.9112992270887008 0.6706077438596076 1.0 P63208
Oxidative stress induced senescence 1 69 0.5882352941176471 0.8181940718302647 1.0 Q00534
The phototransduction cascade 0 12 0.0 1.0 1.0
Condensation of prometaphase chromosomes 1 11 4.0234817813765185 0.2373820829012167 1.0 P19784
Activation of the phototransduction cascade 0 2 0.0 1.0 1.0
Cohesin loading onto chromatin 0 10 0.0 1.0 1.0
Establishment of sister chromatid cohesion 0 11 0.0 1.0 1.0
Mastl facilitates mitotic progression 1 10 4.470985155195682 0.21835116687336614 1.0 P30154
The canonical retinoid cycle in rods twilight vision 0 4 0.0 1.0 1.0
Retinoid cycle disease events 0 2 0.0 1.0 1.0
Interaction with cumulus cells and the zona pellucida 0 1 0.0 1.0 1.0
Acetylcholine neurotransmitter release cycle 0 11 0.0 1.0 1.0
Caspase mediated cleavage of cytoskeletal proteins 1 12 3.6573426573426575 0.25595147351442515 1.0 P55212
Signaling by notch1 t 7 9 notch1 m1580 k2555 translocation mutant 0 4 0.0 1.0 1.0
Ecm proteoglycans 0 37 0.0 1.0 1.0
Non integrin membrane ecm interactions 0 37 0.0 1.0 1.0
Syndecan interactions 0 20 0.0 1.0 1.0
Laminin interactions 0 23 0.0 1.0 1.0
Nuclear envelope ne reassembly 2 71 1.1640155531990102 0.5185914106235352 1.0 P04350,P55735
Initiation of nuclear envelope ne reformation 0 20 0.0 1.0 1.0
Sumoylation 2 155 0.520484616610872 0.8948011782396341 1.0 P55735,Q99497
Activation of nima kinases nek9 nek6 nek7 0 7 0.0 1.0 1.0
Nuclear envelope breakdown 1 54 0.7558628065082882 0.7363690750519482 1.0 P55735
Peptide hormone metabolism 2 43 1.9645052548086457 0.2813288077075832 1.0 O00471,O60645
Notch2 activation and transmission of signal to the nucleus 0 16 0.0 1.0 1.0
Pou5f1 oct4 sox2 nanog activate genes related to proliferation 0 8 0.0 1.0 1.0
Pou5f1 oct4 sox2 nanog repress genes related to differentiation 0 6 0.0 1.0 1.0
Fceri mediated ca 2 mobilization 0 20 0.0 1.0 1.0
Fceri mediated mapk activation 0 24 0.0 1.0 1.0
Role of lat2 ntal lab on calcium mobilization 0 12 0.0 1.0 1.0
Signaling by notch1 hd domain mutants in cancer 0 9 0.0 1.0 1.0
Eph ephrin signaling 2 80 1.0287679799874923 0.583401595674496 1.0 O15145,P12931
Stimuli sensing channels 0 38 0.0 1.0 1.0
Shc related events triggered by igf1r 0 7 0.0 1.0 1.0
Activation of gene expression by srebf srebp 1 42 0.9782758961192851 0.6452412597701435 1.0 Q03426
Dap12 signaling 0 19 0.0 1.0 1.0
Metabolism of ingested semet sec mesec into h2se 0 4 0.0 1.0 1.0
Abacavir transmembrane transport 0 2 0.0 1.0 1.0
Hyaluronan uptake and degradation 0 8 0.0 1.0 1.0
Integrin cell surface interactions 0 37 0.0 1.0 1.0
Activation of ppargc1a pgc 1alpha by phosphorylation 0 8 0.0 1.0 1.0
Transcriptional activation of mitochondrial biogenesis 1 51 0.8014574898785425 0.7160479454809648 1.0 P11474
Hyaluronan biosynthesis and export 0 1 0.0 1.0 1.0
Hyaluronan metabolism 0 9 0.0 1.0 1.0
Synthesis of 16 20 hydroxyeicosatetraenoic acids hete 0 1 0.0 1.0 1.0
Synthesis of 15 eicosatetraenoic acid derivatives 0 3 0.0 1.0 1.0
Arachidonic acid metabolism 0 18 0.0 1.0 1.0
Synthesis of 12 eicosatetraenoic acid derivatives 0 2 0.0 1.0 1.0
Synthesis of lipoxins lx 0 1 0.0 1.0 1.0
Synthesis of leukotrienes lt and eoxins ex 0 4 0.0 1.0 1.0
Synthesis of 5 eicosatetraenoic acids 0 3 0.0 1.0 1.0
Synthesis of epoxy eet and dihydroxyeicosatrienoic acids dhet 0 1 0.0 1.0 1.0
Molecules associated with elastic fibres 0 18 0.0 1.0 1.0
Egfr interacts with phospholipase c gamma 0 2 0.0 1.0 1.0
Dopamine neurotransmitter release cycle 0 18 0.0 1.0 1.0
Prc2 methylates histones and dna 0 23 0.0 1.0 1.0
Abacavir transport and metabolism 0 6 0.0 1.0 1.0
Scavenging by class b receptors 0 2 0.0 1.0 1.0
Abacavir metabolism 0 4 0.0 1.0 1.0
Scavenging of heme from plasma 0 2 0.0 1.0 1.0
Signaling by type 1 insulin like growth factor 1 receptor igf1r 0 29 0.0 1.0 1.0
Condensation of prophase chromosomes 0 23 0.0 1.0 1.0
Crosslinking of collagen fibrils 0 10 0.0 1.0 1.0
Constitutive signaling by aberrant pi3k in cancer 1 32 1.2951547603500064 0.5457838138498524 1.0 P12931
Pi3k akt signaling in cancer 2 58 1.4361207897793264 0.4139938852214621 1.0 P12931,Q96B36
Anchoring fibril formation 0 8 0.0 1.0 1.0
Mucopolysaccharidoses 0 9 0.0 1.0 1.0
Notch2 intracellular domain regulates transcription 0 7 0.0 1.0 1.0
Visual phototransduction 0 40 0.0 1.0 1.0
The retinoid cycle in cones daylight vision 0 1 0.0 1.0 1.0
Egfr transactivation by gastrin 0 7 0.0 1.0 1.0
Smad2 smad3 smad4 heterotrimer regulates transcription 0 29 0.0 1.0 1.0
Downregulation of smad2 3 smad4 transcriptional activity 0 23 0.0 1.0 1.0
Transcriptional activity of smad2 smad3 smad4 heterotrimer 0 41 0.0 1.0 1.0
Tgf beta receptor signaling in emt epithelial to mesenchymal transition 1 14 3.094051697290564 0.2917500038862815 1.0 P62942
Tgf beta receptor signaling activates smads 1 28 1.4876293297345928 0.4986229205358068 1.0 P62942
Downregulation of tgf beta receptor signaling 0 22 0.0 1.0 1.0
Binding and uptake of ligands by scavenger receptors 0 17 0.0 1.0 1.0
Dap12 interactions 0 21 0.0 1.0 1.0
Synthesis of prostaglandins pg and thromboxanes tx 0 8 0.0 1.0 1.0
Glyoxylate metabolism and glycine degradation 0 22 0.0 1.0 1.0
Scavenging by class a receptors 0 10 0.0 1.0 1.0
Sumo is conjugated to e1 uba2 sae1 0 5 0.0 1.0 1.0
Cytosolic trna aminoacylation 1 24 1.7470515754268614 0.44658711947191027 1.0 Q13155
Dopamine clearance from the synaptic cleft 0 2 0.0 1.0 1.0
Myoclonic epilepsy of lafora 0 5 0.0 1.0 1.0
Diseases of glycosylation 0 76 0.0 1.0 1.0
Diseases associated with n glycosylation of proteins 0 18 0.0 1.0 1.0
Negative regulation of tcf dependent signaling by wnt ligand antagonists 0 5 0.0 1.0 1.0
Deactivation of the beta catenin transactivating complex 1 36 1.1466743782533255 0.5885248237912099 1.0 Q9UBL3
Dscam interactions 0 9 0.0 1.0 1.0
Trna aminoacylation 1 43 0.9548872180451128 0.6539058419658339 1.0 Q13155
Peptide ligand binding receptors 1 17 2.513157894736842 0.3422564852890665 1.0 Q9NRV9
L1cam interactions 3 91 1.3719851576994435 0.38180624229540333 1.0 P04350,P12931,P19784
Semaphorin interactions 1 48 0.8528727711258506 0.6941672260159233 1.0 P08134
Nephrin family interactions 0 17 0.0 1.0 1.0
Netrin 1 signaling 1 33 1.2545546558704452 0.5568666172945154 1.0 P12931
Class b 2 secretin family receptors 0 25 0.0 1.0 1.0
Class a 1 rhodopsin like receptors 1 21 2.0097165991902832 0.4040612158985918 1.0 Q9NRV9
Signaling by gpcr 6 204 1.2208865514650638 0.37715246071732444 1.0 P08134,P12931,P30154,P63096,Q01970,Q9NRV9
P130cas linkage to mapk signaling for integrins 1 9 5.030364372469635 0.1988473022417859 1.0 P12931
Ncam signaling for neurite out growth 1 34 1.216415163783585 0.5676800659750835 1.0 P12931
Mitochondrial trna aminoacylation 0 23 0.0 1.0 1.0
Chemokine receptors bind chemokines 0 3 0.0 1.0 1.0
Recruitment of mitotic centrosome proteins and complexes 3 82 1.5296822526478946 0.3217703689336544 1.0 O75935,P04350,P07437
Cd28 dependent vav1 pathway 0 7 0.0 1.0 1.0
Cd28 dependent pi3k akt signaling 0 15 0.0 1.0 1.0
Cd28 co stimulation 1 24 1.7470515754268614 0.44658711947191027 1.0 P12931
Receptor type tyrosine protein phosphatases 0 11 0.0 1.0 1.0
Costimulation by the cd28 family 2 39 2.177763128982641 0.2450354162713742 1.0 P12931,P30154
Transport of small molecules 8 377 0.8653116531165311 0.703231988944655 1.0 O76003,P23634,P25787,P25789,P49720,P55036,P63208,Q9UL46
Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 0 12 0.0 1.0 1.0
Olfactory signaling pathway 0 2 0.0 1.0 1.0
Glucagon like peptide 1 glp1 regulates insulin secretion 0 27 0.0 1.0 1.0
Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0 56 0.0 1.0 1.0
Transcriptional regulation of white adipocyte differentiation 1 68 0.5970753519850142 0.8136305222078131 1.0 P24468
Atf6 atf6 alpha activates chaperone genes 0 6 0.0 1.0 1.0
Unfolded protein response upr 1 75 0.5402122770543824 0.8433303264525713 1.0 P51858
Ire1alpha activates chaperones 1 44 0.9325863854627624 0.6623596340642164 1.0 P51858
Perk regulates gene expression 0 26 0.0 1.0 1.0
Atf6 atf6 alpha activates chaperones 0 8 0.0 1.0 1.0
Atf4 activates genes in response to endoplasmic reticulum stress 0 22 0.0 1.0 1.0
Energy dependent regulation of mtor by lkb1 ampk 0 27 0.0 1.0 1.0
Recruitment of numa to mitotic centrosomes 3 90 1.3878958479943702 0.37517408952038533 1.0 O75935,P04350,P07437
Transcriptional regulation by tp53 10 333 1.2520488071389546 0.29243386867795595 1.0 O14727,P19784,P30154,P35244,P35250,P42575,P55212,Q8N0Z6,Q99873,Q9UIV1
Defective b4galt1 causes b4galt1 cdg cdg 2d 0 1 0.0 1.0 1.0
Defective ext2 causes exostoses 2 0 11 0.0 1.0 1.0
Defective chst6 causes mcdc1 0 1 0.0 1.0 1.0
Defects in cobalamin b12 metabolism 0 10 0.0 1.0 1.0
Trp channels 0 7 0.0 1.0 1.0
Irf3 mediated induction of type i ifn 0 8 0.0 1.0 1.0
Chromatin modifying enzymes 7 210 1.3943339533552725 0.2506518562870811 1.0 O14929,O60678,Q8IUF8,Q96EB1,Q99873,Q9BQA1,Q9UBL3
Wnt ligand biogenesis and trafficking 0 9 0.0 1.0 1.0
Sumoylation of ubiquitinylation proteins 1 39 1.0558278286810143 0.6179297811879729 1.0 P55735
Sumoylation of transcription factors 0 18 0.0 1.0 1.0
Glycogen storage diseases 0 10 0.0 1.0 1.0
Processing and activation of sumo 0 10 0.0 1.0 1.0
Hats acetylate histones 2 90 0.9109386548410938 0.6476315526587827 1.0 O14929,Q96EB1
Hdms demethylate histones 1 25 1.674089068825911 0.46007968674438166 1.0 Q8IUF8
Pkmts methylate histone lysines 1 46 0.8909581646423752 0.6786551558910596 1.0 Q9UBL3
Hdacs deacetylate histones 0 40 0.0 1.0 1.0
Regulation of innate immune responses to cytosolic dna 0 11 0.0 1.0 1.0
Lrr flii interacting protein 1 lrrfip1 activates type i ifn production 0 5 0.0 1.0 1.0
Dex h box helicases activate type i ifn and inflammatory cytokines production 0 7 0.0 1.0 1.0
Sumoylation of dna damage response and repair proteins 1 76 0.5329554655870445 0.8471692829873618 1.0 P55735
Sumo is proteolytically processed 0 6 0.0 1.0 1.0
Sumo is transferred from e1 to e2 ube2i ubc9 0 7 0.0 1.0 1.0
Defects in vitamin and cofactor metabolism 0 18 0.0 1.0 1.0
Scavenging by class f receptors 0 5 0.0 1.0 1.0
Detoxification of reactive oxygen species 0 24 0.0 1.0 1.0
Loss of function of smad2 3 in cancer 0 7 0.0 1.0 1.0
Defective chsy1 causes tpbs 0 4 0.0 1.0 1.0
Defective chst14 causes eds musculocontractural type 0 4 0.0 1.0 1.0
Defective chst3 causes sedcjd 0 4 0.0 1.0 1.0
Defective b4galt7 causes eds progeroid type 0 13 0.0 1.0 1.0
Diseases associated with glycosaminoglycan metabolism 0 26 0.0 1.0 1.0
Grb2 sos provides linkage to mapk signaling for integrins 1 9 5.030364372469635 0.1988473022417859 1.0 P12931
Integrin signaling 1 18 2.3650869254584426 0.3582816735878424 1.0 P12931
Amino acid transport across the plasma membrane 0 17 0.0 1.0 1.0
Apoptotic cleavage of cell adhesion proteins 0 9 0.0 1.0 1.0
Notch hlh transcription pathway 0 21 0.0 1.0 1.0
Hsf1 dependent transactivation 1 30 1.3847549909255898 0.5227832512917782 1.0 Q96B36
Attenuation phase 0 22 0.0 1.0 1.0
Cellular response to heat stress 3 93 1.3412244897959185 0.39502282815301776 1.0 P35244,P55735,Q96B36
Hsf1 activation 1 25 1.674089068825911 0.46007968674438166 1.0 P35244
Regulation of hsf1 mediated heat shock response 2 76 1.084816523840914 0.5554085867446563 1.0 P35244,P55735
Regulation by c flip 0 10 0.0 1.0 1.0
Defects in biotin btn metabolism 0 8 0.0 1.0 1.0
Glycogen synthesis 0 11 0.0 1.0 1.0
Signaling by tgf beta receptor complex in cancer 1 8 5.749566223250434 0.17885878423025256 1.0 P62942
Nuclear pore complex npc disassembly 1 36 1.1466743782533255 0.5885248237912099 1.0 P55735
Ion channel transport 1 82 0.49317738791423 0.8683131896331404 1.0 P23634