| term overlap setsize score pval |
| Metabolism of amino acids and derivatives 80 195 -4.917151256448652 8.781270195434843e-07 |
| Activation of the phototransduction cascade 1 1 -4.797359119170092 1.6077120892354912e-06 |
| Sensory perception of taste 1 1 -4.797359119170092 1.6077120892354912e-06 |
| Olfactory signaling pathway 1 1 -4.797359119170092 1.6077120892354912e-06 |
| Regulation of gene expression by hypoxia inducible factor 0 1 4.785891916380876 1.7022965308477469e-06 |
| Dermatan sulfate biosynthesis 0 1 4.74779423438097 2.05647093776129e-06 |
| Defective chst14 causes eds musculocontractural type 0 1 4.74779423438097 2.05647093776129e-06 |
| Rrna processing 47 168 -4.724256110522216 2.309592039395625e-06 |
| Hs gag biosynthesis 0 1 4.718372056048951 2.377394103802999e-06 |
| Surfactant metabolism 0 1 4.709525534337608 2.4829410811832986e-06 |
| Irs activation 1 1 -4.6887735276247255 2.748473582503408e-06 |
| Tnfr1 mediated ceramide production 1 1 -4.654741461535239 3.243874851843742e-06 |
| Sulfide oxidation to sulfate 0 1 4.6532825696113695 3.2669206695423725e-06 |
| Acetylcholine regulates insulin secretion 1 1 -4.639902467472259 3.4857365105445126e-06 |
| Transport of nucleotide sugars 0 1 4.630978265799287 3.6394207905132703e-06 |
| Signaling by tgf beta receptor complex in cancer 1 1 -4.628012639322158 3.691914897796522e-06 |
| Defective factor ix causes hemophilia b 0 1 4.623530411601316 3.772634008525344e-06 |
| Gamma carboxylation transport and amino terminal cleavage of proteins 0 1 4.623530411601316 3.772634008525344e-06 |
| Defects of contact activation system cas and kallikrein kinin system kks 0 1 4.623530411601316 3.772634008525344e-06 |
| Choline catabolism 1 1 -4.580286473272505 4.643394688308433e-06 |
| Dopamine clearance from the synaptic cleft 0 1 4.56821117110712 4.919043140150237e-06 |
| Activation of caspases through apoptosome mediated cleavage 1 1 -4.539807795390998 5.6305531059841485e-06 |
| Caspase activation via dependence receptors in the absence of ligand 1 1 -4.539807795390998 5.6305531059841485e-06 |
| Release of apoptotic factors from the mitochondria 0 1 4.52459747468673 6.051056013367528e-06 |
| Pi3k akt activation 1 1 -4.482507897538795 7.37709117437646e-06 |
| Rho gtpases activate rhotekin and rhophilins 1 1 -4.482507897538795 7.37709117437646e-06 |
| Acyl chain remodelling of pc 0 1 4.473173999429661 7.706701561582818e-06 |
| Scavenging by class b receptors 0 1 4.462547515623995 8.099096136859885e-06 |
| Ubiquinol biosynthesis 1 1 -4.456747313100548 8.321259056920383e-06 |
| Toxicity of botulinum toxin type d botd 0 1 4.433635935922611 9.26570400139326e-06 |
| Neurotoxicity of clostridium toxins 0 1 4.433635935922611 9.26570400139326e-06 |
| Nr1h2 nr1h3 regulate gene expression to control bile acid homeostasis 1 1 -4.432429905603798 9.31769986323161e-06 |
| Androgen biosynthesis 0 1 4.42601096326721 9.599164748630429e-06 |
| Maturation of protein 3a 0 1 4.412268428038484 1.022931794780746e-05 |
| Synthesis of 5 eicosatetraenoic acids 0 1 4.407682545645376 1.04482531952943e-05 |
| Na cl dependent neurotransmitter transporters 0 1 4.401564108184942 1.0747330273730428e-05 |
| Mecp2 regulates transcription factors 1 1 -4.362122976485123 1.2880643046830896e-05 |
| Urea cycle 0 1 4.34629483048553 1.3845643747067982e-05 |
| Synthesis of lipoxins lx 0 1 4.327789743365457 1.5061314275977011e-05 |
| Sodium calcium exchangers 1 1 -4.306685876691453 1.657186808401434e-05 |
| Transport of small molecules 55 159 4.284472871184235 1.8317295669811884e-05 |
| Acyl chain remodelling of pi 0 1 4.276686683395604 1.8969548795988445e-05 |
| Assembly of active lpl and lipc lipase complexes 0 1 4.256468186874762 2.076815724127989e-05 |
| Metabolism of lipids 81 197 4.224328284576831 2.3965449789553617e-05 |
| Abacavir transmembrane transport 0 1 4.193944864483233 2.741446428600192e-05 |
| Protein repair 1 1 -4.185293635114499 2.847977046616101e-05 |
| Phospholipid metabolism 24 49 4.170648355823647 3.0373424306118224e-05 |
| Triglyceride biosynthesis 0 1 4.160929047906326 3.1695555471777936e-05 |
| Runx1 regulates estrogen receptor mediated transcription 0 1 4.160929047906326 3.1695555471777936e-05 |
| Estrogen biosynthesis 0 1 4.15777775488998 3.2135843200054026e-05 |
| Maturation of sars cov 1 nucleoprotein 2 2 -4.156317244757208 3.234186551237528e-05 |
| Signaling by bmp 1 1 -4.15230599200528 3.291417573603184e-05 |
| Bicarbonate transporters 0 1 4.138844548987667 3.490593539079434e-05 |
| Met receptor activation 1 1 -4.122346472082797 3.7503255699400384e-05 |
| Hydrolysis of lpc 0 1 4.099259389455638 4.144743100287229e-05 |
| Cation coupled chloride cotransporters 0 1 4.081781104691889 4.46918797645246e-05 |
| Metabolism of angiotensinogen to angiotensins 0 1 4.080190316035941 4.499884318076575e-05 |
| Glycerophospholipid catabolism 0 1 4.062671175936742 4.851434737962457e-05 |
| Attachment and entry 1 1 -4.047766383847666 5.1708717697884765e-05 |
| Tnf receptor superfamily tnfsf members mediating non canonical nf kb pathway 1 1 -4.007819754229924 6.128186101062028e-05 |
| Aflatoxin activation and detoxification 1 2 -3.9595165966453534 7.510162543877819e-05 |
| Protein localization 40 78 3.957865263639319 7.562259247850811e-05 |
| Fibronectin matrix formation 0 1 3.9502951319496185 7.80548849801388e-05 |
| Laminin interactions 0 1 3.9502951319496185 7.80548849801388e-05 |
| Molecules associated with elastic fibres 0 1 3.9502951319496185 7.80548849801388e-05 |
| Elastic fibre formation 0 1 3.9502951319496185 7.80548849801388e-05 |
| Other semaphorin interactions 0 1 3.9502951319496185 7.80548849801388e-05 |
| Nr1h2 nr1h3 regulate gene expression linked to lipogenesis 0 2 3.948938829489613 7.849840608820102e-05 |
| Metabolism of rna 131 464 -3.9377581586599337 8.224642535958893e-05 |
| Sodium proton exchangers 0 1 3.935733494954041 8.294297665978334e-05 |
| Chylomicron assembly 0 2 3.9164872824206873 8.984855321325647e-05 |
| Metabolism of ingested semet sec mesec into h2se 1 2 -3.9009068692446505 9.583301542814836e-05 |
| Neurotransmitter clearance 0 2 3.8944987297075313 9.840200751387584e-05 |
| Acyl chain remodelling of pg 1 2 3.8834139955275 0.0001029999747561 |
| Loss of mecp2 binding ability to the ncor smrt complex 2 2 -3.8500622941038527 0.0001180877869115 |
| Sphingolipid metabolism 18 26 3.84262555079456 0.0001217251098493 |
| Netrin mediated repulsion signals 1 1 -3.836255025369778 0.0001249246856862 |
| Activation of irf3 irf7 mediated by tbk1 ikk epsilon 1 1 -3.836255025369778 0.0001249246856862 |
| Arms mediated activation 0 1 3.7969000939833406 0.0001465168036438 |
| Signaling by robo receptors 55 136 -3.789865393174275 0.0001507289417241 |
| Pka mediated phosphorylation of key metabolic factors 1 1 -3.783747537511797 0.0001544845294083 |
| Hdl assembly 1 1 -3.783747537511797 0.0001544845294083 |
| Synthesis of bile acids and bile salts via 24 hydroxycholesterol 0 1 3.778757782785693 0.0001576126383096 |
| Rrna modification in the nucleus and cytosol 21 58 -3.774867433958176 0.000160092776742 |
| Glycerophospholipid biosynthesis 20 33 3.763235412658125 0.0001677291730957 |
| Collagen degradation 0 1 3.734052633936771 0.0001884230898565 |
| Noncanonical activation of notch3 0 2 3.706169219857709 0.0002104177385948 |
| Lrr flii interacting protein 1 lrrfip1 activates type i ifn production 1 2 -3.68741604274992 0.0002265428024788 |
| Creb phosphorylation 1 2 3.682024242049157 0.000231389401897 |
| Cellular hexose transport 0 1 3.658987178881534 0.0002532140064628 |
| Plasma lipoprotein remodeling 0 2 3.649071676257128 0.000263189669706 |
| Traf6 mediated irf7 activation in tlr7 8 or 9 signaling 0 1 3.635489556162673 0.0002774532348246 |
| Proton coupled monocarboxylate transport 1 2 3.608219056486356 0.0003083061298108 |
| Passive transport by aquaporins 0 1 3.59673609309552 0.0003222351143363 |
| Digestion 0 1 3.588286548044028 0.0003328583447304 |
| Digestion and absorption 0 1 3.588286548044028 0.0003328583447304 |
| Arachidonate production from dag 1 2 3.5778993051159524 0.0003463668309728 |
| Hdl clearance 0 2 3.550701266033652 0.0003842062447625 |
| Antimicrobial peptides 1 2 -3.54664171798451 0.0003901748236527 |
| Tfap2 ap 2 family regulates transcription of growth factors and their receptors 0 1 3.4981680419169767 0.0004684658651981 |
| Regulation of expression of slits and robos 40 123 -3.497115863374457 0.0004703175161493 |
| Nectin necl trans heterodimerization 0 1 3.493036461652601 0.0004775612974787 |
| Developmental biology 75 256 -3.491472986473994 0.0004803650383755 |
| The canonical retinoid cycle in rods twilight vision 0 1 3.479336092811213 0.0005026577506705 |
| Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde 0 2 3.4765175456399 0.0005079709899549 |
| Mrna editing 1 1 -3.4750774247463965 0.0005107059254996 |
| Potassium channels 2 3 -3.466933714148436 0.0005264316920245 |
| Inwardly rectifying k channels 2 3 -3.466933714148436 0.0005264316920245 |
| Presynaptic function of kainate receptors 2 3 -3.466933714148436 0.0005264316920245 |
| Glucagon type ligand receptors 2 3 -3.466933714148436 0.0005264316920245 |
| G protein activation 2 3 -3.466933714148436 0.0005264316920245 |
| Prostacyclin signalling through prostacyclin receptor 2 3 -3.466933714148436 0.0005264316920245 |
| Scavenging by class a receptors 1 2 -3.4564025517371983 0.0005474371069578 |
| Atf6 atf6 alpha activates chaperone genes 1 2 -3.4564025517371983 0.0005474371069578 |
| Atf6 atf6 alpha activates chaperones 1 2 -3.4564025517371983 0.0005474371069578 |
| Slbp dependent processing of replication dependent histone pre mrnas 3 3 -3.444828234525424 0.000571422382418 |
| Diseases associated with o glycosylation of proteins 0 2 3.429244903142592 0.0006052631084234 |
| Calcineurin activates nfat 2 2 -3.4247204827099824 0.0006154322458333 |
| N glycan antennae elongation in the medial trans golgi 1 2 3.418367663862114 0.0006299794472957 |
| Reactions specific to the complex n glycan synthesis pathway 1 2 3.418367663862114 0.0006299794472957 |
| Chylomicron clearance 1 2 -3.3549216685525427 0.0007938746048794 |
| Competing endogenous rnas cernas regulate pten translation 0 1 3.351478816893119 0.0008038118829827 |
| Regulation of pten mrna translation 0 1 3.351478816893119 0.0008038118829827 |
| Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip 1 3 3.341925242546914 0.0008319946541917 |
| Synthesis secretion and deacylation of ghrelin 1 3 3.341925242546914 0.0008319946541917 |
| Tyrosine catabolism 2 2 -3.3394311357963664 0.0008395016234779 |
| Creatine metabolism 3 3 -3.3000396122772684 0.00096671182393 |
| Acyl chain remodelling of ps 0 1 3.297300741316312 0.0009761891320712 |
| Mitochondrial protein import 22 37 3.292639309523232 0.0009925171376778 |
| Defects in vitamin and cofactor metabolism 5 11 -3.2908418975582023 0.0009988803605054 |
| Signaling by nodal 1 1 -3.2725163330403912 0.0010659471356233 |
| Signaling by activin 1 1 -3.2725163330403912 0.0010659471356233 |
| Estrogen stimulated signaling through prkcz 1 1 -3.2725163330403912 0.0010659471356233 |
| Metabolism of vitamins and cofactors 8 50 -3.2589248518190272 0.0011183528709124 |
| Intrinsic pathway of fibrin clot formation 1 2 3.2556000612266365 0.0011315301714043 |
| Formation of fibrin clot clotting cascade 1 2 3.2556000612266365 0.0011315301714043 |
| Nervous system development 61 209 -3.250654725040521 0.0011513959726143 |
| Gp1b ix v activation signalling 1 2 -3.248555534664934 0.0011599256425531 |
| Erythropoietin activates ras 1 3 -3.225706089142362 0.0012566232851389 |
| Runx1 regulates expression of components of tight junctions 0 2 3.200343355794995 0.0013726395939519 |
| Selenoamino acid metabolism 38 91 -3.19895021897546 0.0013792898329971 |
| G2 phase 0 1 3.1913799122212367 0.0014159495897543 |
| Er quality control compartment erqc 1 3 3.1905883763249125 0.0014198340895124 |
| Organic anion transporters 0 2 3.189631895707058 0.0014245411715083 |
| Irak4 deficiency tlr2 4 0 1 3.1878248061746413 0.0014334736015917 |
| Regulation of tlr by endogenous ligand 0 1 3.1878248061746413 0.0014334736015917 |
| Alpha protein kinase 1 signaling pathway 1 1 -3.175518455256647 0.001495690072794 |
| Irak2 mediated activation of tak1 complex 1 1 -3.175518455256647 0.001495690072794 |
| Traf6 mediated induction of tak1 complex within tlr4 complex 1 1 -3.175518455256647 0.001495690072794 |
| Ticam1 traf6 dependent induction of tak1 complex 1 1 -3.175518455256647 0.001495690072794 |
| Formation of xylulose 5 phosphate 3 3 -3.174296381406463 0.0015020023419631 |
| Transport of bile salts and organic acids metal ions and amine compounds 2 3 3.161596026760167 0.0015690707420448 |
| Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells 0 1 3.139674690638848 0.0016913553868251 |
| Runx3 regulates notch signaling 0 1 3.139674690638848 0.0016913553868251 |
| Apobec3g mediated resistance to hiv 1 infection 1 2 -3.1385333759826795 0.0016979559709313 |
| Effects of pip2 hydrolysis 2 3 3.1325671949895293 0.0017328475757805 |
| Negative regulation of flt3 1 1 -3.1256892321584093 0.0017738890070202 |
| Biotin transport and metabolism 6 9 -3.1199576412430905 0.0018087704837812 |
| Integration of energy metabolism 5 24 -3.1084201561407667 0.0018809046084922 |
| Neurofascin interactions 0 1 3.103819098813351 0.0019104010053427 |
| Biosynthesis of specialized proresolving mediators spms 0 2 3.097892015308291 0.0019490243244419 |
| Synthesis of leukotrienes lt and eoxins ex 0 2 3.097892015308291 0.0019490243244419 |
| Slc mediated transmembrane transport 17 21 3.081425591023933 0.0020601195952099 |
| Metabolism of water soluble vitamins and cofactors 7 42 -3.071182532814727 0.0021321276376806 |
| Diseases of base excision repair 1 1 -3.068365491834838 0.0021523319791265 |
| Propionyl coa catabolism 1 3 -3.060437920390397 0.0022101357335553 |
| Activated ntrk2 signals through cdk5 1 2 -3.0465127273333525 0.0023151267774492 |
| Regulation of gene expression in beta cells 0 1 3.0424914548163526 0.0023462847890234 |
| Runx2 regulates genes involved in cell migration 0 1 3.0424914548163526 0.0023462847890234 |
| Akt phosphorylates targets in the nucleus 0 1 3.0424914548163526 0.0023462847890234 |
| Erbb2 regulates cell motility 1 2 -3.022838641365432 0.0025041572810993 |
| Norepinephrine neurotransmitter release cycle 0 1 3.0207331749151383 0.0025216346602547 |
| Serotonin neurotransmitter release cycle 0 1 3.0207331749151383 0.0025216346602547 |
| Receptor type tyrosine protein phosphatases 0 1 3.0207331749151383 0.0025216346602547 |
| Acetylcholine neurotransmitter release cycle 0 1 3.0207331749151383 0.0025216346602547 |
| Egfr interacts with phospholipase c gamma 0 1 3.0134671960063173 0.0025828096240334 |
| Phospholipase c mediated cascade fgfr2 0 1 3.0134671960063173 0.0025828096240334 |
| Role of second messengers in netrin 1 signaling 0 1 3.0134671960063173 0.0025828096240334 |
| Phospholipase c mediated cascade fgfr4 0 1 3.0134671960063173 0.0025828096240334 |
| Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 25 61 3.0130923555003903 0.0025860020522037 |
| Mrna splicing minor pathway 12 31 -3.0066221084870635 0.0026416793226045 |
| Defects in biotin btn metabolism 5 7 -3.00170661947263 0.002684707770914 |
| Synthesis of dolichyl phosphate 0 2 2.9980489583864616 0.0027171402028167 |
| Rho gtpase cycle 54 154 2.993580375727599 0.0027572487348919 |
| Adp signalling through p2y purinoceptor 1 2 4 -2.986680329900157 0.002820244529317 |
| Chromatin modifying enzymes 36 73 -2.98581446440834 0.0028282418111371 |
| Rac2 gtpase cycle 12 33 2.9828124971149617 0.0028561291074962 |
| P130cas linkage to mapk signaling for integrins 1 1 -2.9779831669030026 0.0029015191954224 |
| Eukaryotic translation elongation 32 77 -2.9731656156816064 0.002947453664521 |
| Pre notch processing in golgi 2 4 2.9715182251479746 0.0029633128539596 |
| Synthesis of pe 1 2 2.97074635740036 0.0029707702665739 |
| Abacavir transport and metabolism 0 2 2.969921695760228 0.0029787566652026 |
| Galactose catabolism 2 3 -2.9658249067873625 0.0030187229776363 |
| P75ntr negatively regulates cell cycle via sc1 1 2 -2.9570803599917457 0.0031056716625277 |
| Signaling by ntrk3 trkc 0 3 2.954279343152004 0.003134001831297 |
| Serine biosynthesis 1 2 -2.945066869712252 0.0032288487124683 |
| Fbxw7 mutants and notch1 in cancer 0 2 2.944583909738769 0.003233892434024 |
| Tlr3 mediated ticam1 dependent programmed cell death 1 1 -2.9397229830285214 0.0032850580177887 |
| Trif mediated programmed cell death 1 1 -2.9397229830285214 0.0032850580177887 |
| Trp channels 1 1 -2.9397229830285214 0.0032850580177887 |
| Nade modulates death signalling 1 2 -2.9366692790943363 0.0033175769971194 |
| Vitamin b1 thiamin metabolism 1 2 2.9346239801184115 0.0033395211048841 |
| Sema4d mediated inhibition of cell attachment and migration 2 3 -2.934284218398399 0.0033431792009155 |
| Ras signaling downstream of nf1 loss of function variants 1 1 -2.93241506515319 0.0033633690607739 |
| Phenylalanine metabolism 1 3 -2.9322255239031625 0.0033654225988226 |
| Mitochondrial fatty acid beta oxidation 8 18 -2.92792567573235 0.0034123160472083 |
| Runx3 regulates cdkn1a transcription 1 1 -2.926929858475652 0.0034232607552751 |
| Activation of noxa and translocation to mitochondria 1 1 -2.926929858475652 0.0034232607552751 |
| Activation of puma and translocation to mitochondria 1 1 -2.926929858475652 0.0034232607552751 |
| Tp53 regulates transcription of genes involved in cytochrome c release 1 1 -2.926929858475652 0.0034232607552751 |
| Activation of the tfap2 ap 2 family of transcription factors 1 1 -2.9251006425543884 0.0034434483798961 |
| Rrna modification in the mitochondrion 0 1 2.9220797982248583 0.0034770244387645 |
| Glycogen storage diseases 1 3 2.9136145996930995 0.0035727067734991 |
| Tgf beta receptor signaling in emt epithelial to mesenchymal transition 2 3 -2.912583187102961 0.0035845271041592 |
| Abacavir metabolism 0 1 2.9073603261535133 0.0036449307780141 |
| Gaba synthesis release reuptake and degradation 2 3 -2.9023536308377764 0.0037037019076815 |
| Met activates pi3k akt signaling 1 2 -2.8939837979327367 0.0038038778934161 |
| Signaling by tgfb family members 10 20 -2.8775186113037026 0.0040081626607113 |
| Recognition and association of dna glycosylase with site containing an affected purine 1 2 -2.863566060731898 0.0041890145361556 |
| Keratan sulfate biosynthesis 1 2 2.861889816017251 0.0042112328111163 |
| Vitamin d calciferol metabolism 1 3 2.8554393370133027 0.004297733222689 |
| Heme degradation 1 4 2.848156411286041 0.0043973306963587 |
| Robo receptors bind akap5 2 2 -2.844719762184049 0.0044450511178104 |
| Formyl peptide receptors bind formyl peptides and many other ligands 1 3 2.841074833996498 0.0044961760345905 |
| Metabolism of nucleotides 23 47 -2.8348836208853405 0.0045842382177399 |
| Signaling by mras complex mutants 2 3 -2.8254473333437278 0.0047214649109901 |
| Vitamin b2 riboflavin metabolism 0 1 2.8184710697387296 0.0048252959188175 |
| Linoleic acid la metabolism 1 2 2.7951949446580326 0.0051868427514354 |
| Nonsense mediated decay nmd 34 86 -2.7946033503888392 0.0051963428214458 |
| Runx3 regulates wnt signaling 0 1 2.7942266012006343 0.0052024010100302 |
| Binding of tcf lef ctnnb1 to target gene promoters 0 1 2.7942266012006343 0.0052024010100302 |
| Role of phospholipids in phagocytosis 1 3 2.784896695130218 0.0053544779194327 |
| Regulation of cytoskeletal remodeling and cell spreading by ipp complex components 1 3 2.7848720807213514 0.0053548843875108 |
| Rhog gtpase cycle 13 36 2.778989509640569 0.0054528286036552 |
| Fructose metabolism 2 3 -2.77828017759428 0.005464747519901 |
| Lgi adam interactions 1 1 -2.771844968363372 0.0055739576364981 |
| Regulation of fzd by ubiquitination 1 1 -2.766252225041156 0.0056704657876589 |
| Myoclonic epilepsy of lafora 0 1 2.766161216267736 0.0056720486182413 |
| Erythropoietin activates stat5 0 1 2.7642867126938007 0.0057047388717734 |
| Erythropoietin activates phosphoinositide 3 kinase pi3k 0 1 2.7642867126938007 0.0057047388717734 |
| Cd22 mediated bcr regulation 0 1 2.7642867126938007 0.0057047388717734 |
| Dectin 2 family 0 1 2.7642867126938007 0.0057047388717734 |
| Ncam1 interactions 1 1 -2.7587893948266244 0.0058015910975619 |
| Insertion of tail anchored proteins into the endoplasmic reticulum membrane 7 13 2.7569484713941 0.0058343544846386 |
| Sos mediated signalling 0 1 2.756784341407075 0.0058372836314239 |
| Grb2 events in erbb2 signaling 0 1 2.756784341407075 0.0058372836314239 |
| Activated ntrk3 signals through ras 0 1 2.756784341407075 0.0058372836314239 |
| Interleukin receptor shc signaling 0 1 2.756784341407075 0.0058372836314239 |
| Shc mediated cascade fgfr3 0 1 2.756784341407075 0.0058372836314239 |
| Pi3k events in erbb2 signaling 0 1 2.756784341407075 0.0058372836314239 |
| Shc mediated cascade fgfr1 0 1 2.756784341407075 0.0058372836314239 |
| Shc mediated cascade fgfr4 0 1 2.756784341407075 0.0058372836314239 |
| Egfr transactivation by gastrin 0 1 2.756784341407075 0.0058372836314239 |
| Activated ntrk2 signals through ras 0 1 2.756784341407075 0.0058372836314239 |
| Shc related events triggered by igf1r 0 1 2.756784341407075 0.0058372836314239 |
| Shc1 events in erbb2 signaling 0 1 2.756784341407075 0.0058372836314239 |
| Signaling by fgfr3 fusions in cancer 0 1 2.756784341407075 0.0058372836314239 |
| Shc1 events in erbb4 signaling 0 1 2.756784341407075 0.0058372836314239 |
| Activated ntrk2 signals through pi3k 0 1 2.756784341407075 0.0058372836314239 |
| Shc1 events in egfr signaling 0 1 2.756784341407075 0.0058372836314239 |
| Epigenetic regulation of gene expression 26 44 -2.7559659639216743 0.0058519086043822 |
| The activation of arylsulfatases 1 2 2.7464959323265057 0.0060235632960461 |
| Ptk6 expression 1 1 -2.745713366436528 0.0060379490954125 |
| Beta catenin independent wnt signaling 21 57 -2.740316171333909 0.0061380107184847 |
| Trna aminoacylation 21 36 -2.738009997365946 0.0061812196847661 |
| Abc transporters in lipid homeostasis 1 3 2.734857044740407 0.0062407372665729 |
| Oas antiviral response 2 3 -2.7309284652577586 0.0063156178472385 |
| Synthesis of pg 3 4 2.7302778121735405 0.0063280973636621 |
| Cristae formation 13 19 2.729512866862059 0.0063427973838237 |
| Enos activation 2 4 -2.7285714387269437 0.0063609310707493 |
| Ptk6 regulates cell cycle 1 2 2.7279473800121896 0.0063729773219469 |
| Foxo mediated transcription of oxidative stress metabolic and neuronal genes 2 4 -2.7265295101726856 0.0064004229072918 |
| Asparagine n linked glycosylation 38 127 2.7247820754141627 0.00643439413268 |
| Cs ds degradation 1 2 2.7228813507620706 0.0064715295255779 |
| Respiratory electron transport 20 52 2.7227183881397514 0.006474722362866 |
| Mitochondrial calcium ion transport 10 16 2.719284287628424 0.0065423352068092 |
| Adenylate cyclase inhibitory pathway 3 3 -2.7186506233140726 0.0065548803812376 |
| Mitochondrial iron sulfur cluster biogenesis 4 4 -2.71267131771348 0.0066743271246492 |
| Class b 2 secretin family receptors 2 4 -2.711980526663842 0.0066882521862468 |
| Notch2 intracellular domain regulates transcription 0 1 2.711623261721122 0.0066954642241974 |
| Defective lfng causes scdo3 0 1 2.711623261721122 0.0066954642241974 |
| G2 m dna replication checkpoint 1 3 2.7101264599873014 0.0067257559293509 |
| Glycosphingolipid metabolism 11 15 2.7081696394614205 0.0067655430928665 |
| Response of eif2ak4 gcn2 to amino acid deficiency 29 77 -2.70164942244249 0.0068996470086695 |
| Platelet adhesion to exposed collagen 0 2 2.6964232718729537 0.0070088542589101 |
| Vegfr2 mediated cell proliferation 0 2 2.694963426634322 0.0070396357507593 |
| Akt phosphorylates targets in the cytosol 3 4 -2.6938125091690037 0.0070639888819261 |
| Signaling by tgf beta receptor complex 9 19 -2.691896289544513 0.0071047034828941 |
| Pd 1 signaling 2 2 -2.674179327489162 0.0074912381437957 |
| Signaling by leptin 1 2 -2.6713623546981147 0.0075544048147158 |
| Interleukin 37 signaling 1 2 -2.6713623546981147 0.0075544048147158 |
| Chrebp activates metabolic gene expression 2 5 -2.666520215290749 0.0076640997027084 |
| Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members 0 1 2.6662090739853967 0.0076711969402518 |
| Transcriptional regulation of pluripotent stem cells 0 1 2.6662090739853967 0.0076711969402518 |
| Pou5f1 oct4 sox2 nanog activate genes related to proliferation 0 1 2.6662090739853967 0.0076711969402518 |
| Interleukin 10 signaling 0 1 2.6662090739853967 0.0076711969402518 |
| Rhoa gtpase cycle 16 47 2.6486111350542894 0.0080823270366576 |
| Translation 92 220 -2.63516130088699 0.0084097308715391 |
| Diseases of metabolism 11 47 -2.632966245074513 0.0084642759022317 |
| Dex h box helicases activate type i ifn and inflammatory cytokines production 2 2 -2.6318527734522865 0.0084920653686371 |
| Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s 12 51 -2.6263721687416166 0.008630040101945 |
| Pyrimidine catabolism 0 1 2.622447976653306 0.0087300594934083 |
| Eukaryotic translation initiation 38 102 -2.620344040292193 0.0087841098715655 |
| Mitochondrial fatty acid beta oxidation of unsaturated fatty acids 3 4 -2.602923487366265 0.0092432579543477 |
| Nostrin mediated enos trafficking 0 1 2.593781306727233 0.0094926847092966 |
| Tgf beta receptor signaling activates smads 7 9 -2.5873333103354343 0.009672198077713 |
| Cd28 dependent pi3k akt signaling 1 2 2.586618372796194 0.0096922872694786 |
| Regulation of beta cell development 1 2 2.5866183727961864 0.0096922872694789 |
| Metabolism of steroids 17 49 2.583476248800755 0.0097810201458394 |
| Glyoxylate metabolism and glycine degradation 10 11 -2.565461661307669 0.0103038607624421 |
| Synthesis of pyrophosphates in the cytosol 1 2 -2.564648051589085 0.010328050691279 |
| Cytosolic trna aminoacylation 17 23 -2.558230317786474 0.0105206386901763 |
| Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 9 16 2.542163290695385 0.0110168691307335 |
| Ptk6 regulates proteins involved in rna processing 0 2 2.5384177174123232 0.0111354984747864 |
| Mitochondrial translation 22 54 -2.5256024053605715 0.0115500114130826 |
| Synthesis of ip3 and ip4 in the cytosol 1 3 -2.5246892304950017 0.011580064203748 |
| Hs gag degradation 2 3 2.511852309394303 0.0120099339498662 |
| Rho gtpases activate rocks 4 10 -2.5117963425172367 0.0120118386754746 |
| Maturation of sars cov 2 nucleoprotein 5 5 -2.5091107755888453 0.0121035521065286 |
| Met activates ptpn11 2 3 -2.5047887565755245 0.0122524546664961 |
| Defective ripk1 mediated regulated necrosis 2 2 -2.49844667713219 0.0124738907177981 |
| Rsk activation 1 3 2.496902850996312 0.0125283274239627 |
| Chondroitin sulfate dermatan sulfate metabolism 1 3 2.4911978387467566 0.0127313206430166 |
| Pi5p regulates tp53 acetylation 2 2 -2.486374286495724 0.0129052156253315 |
| Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation 2 3 -2.483632274846706 0.0130050025066177 |
| Signaling by erythropoietin 1 4 -2.47809069197986 0.0132087566011969 |
| Synthesis of pa 8 10 2.476799698944052 0.0132566275417986 |
| Regulated proteolysis of p75ntr 0 1 2.474221730509427 0.0133526796038339 |
| Glucuronidation 0 3 2.466595927176829 0.0136404186765775 |
| Biosynthesis of epa derived spms 1 1 -2.4644109203081053 0.013723867232271 |
| Uch proteinases 21 48 -2.458959812266389 0.0139340214577328 |
| Erythrocytes take up carbon dioxide and release oxygen 0 1 2.4508808153332304 0.0142507130628977 |
| Signal attenuation 1 3 -2.446183405915185 0.0144377535196555 |
| Rho gtpases activate paks 3 11 -2.445795552531294 0.0144532933092307 |
| Ikba variant leads to eda id 1 1 -2.445068398781187 0.0144824673098873 |
| Sumoylation of immune response proteins 1 1 -2.445068398781187 0.0144824673098873 |
| Sphingolipid de novo biosynthesis 5 11 2.4385159845159525 0.0147477064466134 |
| G beta gamma signalling through cdc42 2 5 -2.4335598655415933 0.0149511628117373 |
| Frs mediated fgfr1 signaling 1 2 -2.432611607054496 0.0149903708923018 |
| Pi 3k cascade fgfr2 1 2 -2.432611607054496 0.0149903708923018 |
| Frs mediated fgfr2 signaling 1 2 -2.432611607054496 0.0149903708923018 |
| Frs mediated fgfr3 signaling 1 2 -2.432611607054496 0.0149903708923018 |
| Pi 3k cascade fgfr3 1 2 -2.432611607054496 0.0149903708923018 |
| Frs mediated fgfr4 signaling 1 2 -2.432611607054496 0.0149903708923018 |
| Pi 3k cascade fgfr4 1 2 -2.432611607054496 0.0149903708923018 |
| Signaling by flt3 itd and tkd mutants 1 2 -2.432611607054496 0.0149903708923018 |
| Stat5 activation downstream of flt3 itd mutants 1 2 -2.432611607054496 0.0149903708923018 |
| Tie2 signaling 1 2 -2.432611607054496 0.0149903708923018 |
| Stat5 activation 1 2 -2.432611607054496 0.0149903708923018 |
| Activated ntrk2 signals through frs2 and frs3 1 2 -2.432611607054496 0.0149903708923018 |
| Pi 3k cascade fgfr1 1 2 -2.432611607054496 0.0149903708923018 |
| Complement cascade 1 1 -2.4276236922235928 0.015198103366236 |
| Positive epigenetic regulation of rrna expression 18 28 -2.4208477193425617 0.0154843623196683 |
| P75ntr recruits signalling complexes 1 1 -2.4198594112705365 0.0155265086499545 |
| Nf kb is activated and signals survival 1 1 -2.4198594112705365 0.0155265086499545 |
| P75ntr signals via nf kb 1 1 -2.4198594112705365 0.0155265086499545 |
| Rab geranylgeranylation 13 19 2.419486037418667 0.015542457405925 |
| Thrombin signalling through proteinase activated receptors pars 2 6 -2.4154298784273416 0.0157166483752888 |
| Mapk1 erk2 activation 3 3 -2.412412607789973 0.0158473360787041 |
| Negative feedback regulation of mapk pathway 3 3 -2.412412607789973 0.0158473360787041 |
| Activation of kainate receptors upon glutamate binding 2 5 -2.412402910922839 0.0158477576172342 |
| Rac3 gtpase cycle 12 33 2.4054120171495303 0.0161542413053399 |
| Runx3 regulates p14 arf 1 2 -2.3990539422871824 0.0164374930203152 |
| Rna polymerase ii transcription termination 18 42 -2.395016686989193 0.016619608880505 |
| Telomere maintenance 20 43 -2.391329347718332 0.0167874861530852 |
| Rna polymerase ii transcribes snrna genes 5 30 -2.3823011876128657 0.0172048193389791 |
| Ra biosynthesis pathway 2 3 2.3790584457747848 0.0173569237188537 |
| Amino acid transport across the plasma membrane 3 4 2.3785491823296323 0.0173809181162543 |
| Pink1 prkn mediated mitophagy 6 10 2.3784604693144744 0.0173851008818626 |
| Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 2 4 2.377023886222556 0.017452957901263 |
| Regulation of foxo transcriptional activity by acetylation 1 1 -2.375082583932796 0.0175450242223862 |
| Metabolism of nitric oxide nos3 activation and regulation 3 6 -2.371398111324519 0.0177209318597539 |
| Ecm proteoglycans 1 3 2.3699452361552504 0.0177907201831255 |
| Copi dependent golgi to er retrograde traffic 14 46 2.36940218456106 0.0178168672309342 |
| Synthesis of very long chain fatty acyl coas 3 8 2.367216316207913 0.0179224540618641 |
| G alpha 12 13 signalling events 4 12 -2.36144885270558 0.0182036828093041 |
| Nicotinamide salvaging 0 2 2.3608545789496045 0.0182328787617249 |
| Transport and synthesis of paps 0 3 2.358178463196025 0.0183648616896263 |
| Inla mediated entry of listeria monocytogenes into host cells 1 2 2.3514865024290392 0.0186985680069673 |
| G beta gamma signalling through pi3kgamma 3 5 -2.3493919503368264 0.0188041008493848 |
| Regulation of signaling by cbl 1 4 -2.3461972117410954 0.0189660692754851 |
| Erythropoietin activates phospholipase c gamma plcg 1 2 2.323182287812986 0.0201693618728509 |
| Transport of fatty acids 0 1 2.3213364698678345 0.0202686913869669 |
| Fructose catabolism 1 1 -2.318304359076929 0.0204327856823982 |
| Role of lat2 ntal lab on calcium mobilization 1 2 2.316091721723654 0.0205532612067618 |
| Signaling by fgfr4 in disease 1 2 2.316091721723654 0.0205532612067618 |
| Ngf stimulated transcription 1 3 -2.315906189537673 0.0205633913093836 |
| Downregulation of tgf beta receptor signaling 5 7 -2.3156477747370707 0.0205775080757102 |
| Unwinding of dna 4 10 2.3106539112887483 0.0208519788768524 |
| Semaphorin interactions 7 22 -2.310255653323738 0.0208740045332573 |
| Assembly of the hiv virion 2 2 -2.30507317229958 0.0211624757030191 |
| Glycosaminoglycan metabolism 7 14 2.297925637630724 0.0215660218359063 |
| Peptide ligand binding receptors 5 7 2.2969602861810565 0.0216210353553698 |
| Class a 1 rhodopsin like receptors 5 7 2.2969602861810565 0.0216210353553698 |
| Beta oxidation of very long chain fatty acids 2 4 -2.2904252789605706 0.0219966755176956 |
| Tp53 regulates transcription of caspase activators and caspases 2 2 -2.2856854290919637 0.0222726682963916 |
| G protein beta gamma signalling 3 7 -2.28443921533272 0.022345731089673 |
| Diseases of programmed cell death 10 26 -2.2795105346840843 0.0226367344617952 |
| Thromboxane signalling through tp receptor 2 5 -2.2762233145668294 0.0228326471727084 |
| Notch4 intracellular domain regulates transcription 1 2 2.2734264304897605 0.0230004948952051 |
| Class i peroxisomal membrane protein import 6 8 2.2691065996374857 0.0232618441400056 |
| Heparan sulfate heparin hs gag metabolism 2 4 2.261781991152252 0.0237108760436648 |
| Ldl remodeling 0 1 2.259805228734657 0.0238333417553382 |
| Vldl assembly 0 1 2.259805228734657 0.0238333417553382 |
| Role of abl in robo slit signaling 1 3 -2.252051212712231 0.0243190358581406 |
| Wax and plasmalogen biosynthesis 3 4 2.237862006296568 0.0252300553472959 |
| Activation of rac1 downstream of nmdars 0 3 2.2376996583271267 0.0252406475603774 |
| Cholesterol biosynthesis 8 18 2.235851910124978 0.0253614732893558 |
| Mrna splicing 29 140 -2.2342346247570517 0.0254676393207913 |
| Interleukin 15 signaling 1 2 2.2305523176204027 0.0257107982761819 |
| Activation of anterior hox genes in hindbrain development during early embryogenesis 7 15 -2.23001032946574 0.02574675713417 |
| Rna polymerase ii transcription 84 319 -2.228332024579576 0.0258583823096947 |
| Trafficking and processing of endosomal tlr 0 2 2.216438759005518 0.0266614677008176 |
| Glucagon like peptide 1 glp1 regulates insulin secretion 2 7 -2.212009045218946 0.0269660399549751 |
| Deadenylation dependent mrna decay 14 39 -2.211943930845498 0.0269705393096071 |
| Regulation of commissural axon pathfinding by slit and robo 0 1 2.2098645897797136 0.0271145614226926 |
| Synthesis of prostaglandins pg and thromboxanes tx 1 4 2.2022354758916776 0.0276486793397752 |
| Signaling by wnt in cancer 3 7 -2.197903924869787 0.0279559531582198 |
| Fasl cd95l signaling 0 1 2.1978365754569413 0.0279607539747537 |
| Diseases associated with n glycosylation of proteins 5 7 2.1889616020077645 0.0285996310056764 |
| Pyruvate metabolism and citric acid tca cycle 22 33 -2.1858889692442465 0.0288237294629958 |
| Regulation of pten localization 1 1 -2.181785003864227 0.0291254038514101 |
| Ca2 pathway 2 6 -2.1815150629001065 0.0291453415732725 |
| Ion channel transport 11 28 2.180399606846436 0.0292278532657959 |
| Mitophagy 6 14 2.179416818888267 0.029300717818705 |
| Pyrimidine salvage 1 3 -2.1721062471557357 0.0298476498842137 |
| Eph ephrin signaling 6 32 -2.1586889346995277 0.0308743078175322 |
| Sumo is proteolytically processed 1 1 -2.153843054154124 0.0312524820227104 |
| Integrin cell surface interactions 2 4 2.146520520513435 0.0318314733830746 |
| Glucagon signaling in metabolic regulation 2 6 -2.143734308444239 0.0320541815556267 |
| Vasopressin regulates renal water homeostasis via aquaporins 2 6 -2.143734308444239 0.0320541815556267 |
| Mucopolysaccharidoses 3 4 2.1428277771388697 0.0321269299998183 |
| Chromosome maintenance 20 49 -2.141741358768188 0.0322143006053705 |
| Apex1 independent resolution of ap sites via the single nucleotide replacement pathway 1 3 -2.1409548361276145 0.0322776803554547 |
| Antigen activates b cell receptor bcr leading to generation of second messengers 0 3 2.1315795723540454 0.0330414245435437 |
| Lysine catabolism 6 6 -2.130001191133322 0.0331715150284863 |
| Irf3 mediated activation of type 1 ifn 1 1 -2.12982860325266 0.0331857663049195 |
| Maturation of sars cov 2 spike protein 8 12 2.128997842419338 0.0332544389101114 |
| Transcriptional regulation by e2f6 4 9 -2.123281974504287 0.0337302302589823 |
| Keratan sulfate degradation 2 4 2.122816157811114 0.033769260322354 |
| Uptake and function of anthrax toxins 2 3 -2.122441085932613 0.0338007150790597 |
| Transcription of e2f targets under negative control by dream complex 3 3 -2.119991006303622 0.0340068037608232 |
| Camk iv mediated phosphorylation of creb 0 3 2.1195519725246195 0.0340438463921426 |
| Regulation of pyruvate dehydrogenase pdh complex 6 7 -2.119054977756881 0.0340858209878751 |
| Cdc6 association with the orc origin complex 0 3 2.114064172564361 0.0345097866973993 |
| Translation of replicase and assembly of the replication transcription complex 1 1 -2.1137862437208046 0.0345335284185885 |
| Plasma lipoprotein assembly 0 3 2.1103151593275347 0.0348312187027646 |
| Detoxification of reactive oxygen species 4 9 -2.105419971885549 0.0352547668069387 |
| Branched chain amino acid catabolism 7 16 -2.0998458598001224 0.0357424026008994 |
| Mecp2 regulates transcription of neuronal ligands 1 3 -2.0970511649364965 0.0359890463250054 |
| Triglyceride catabolism 2 5 -2.088098697257185 0.0367889325520216 |
| The nlrp3 inflammasome 1 4 2.087896890520246 0.0368071367413598 |
| Purinergic signaling in leishmaniasis infection 1 4 2.087896890520244 0.03680713674136 |
| Inflammasomes 1 4 2.087896890520244 0.03680713674136 |
| Ire1alpha activates chaperones 5 25 2.078215797177759 0.0376894877481288 |
| Mitochondrial biogenesis 15 34 2.0717661753835506 0.0382872525398119 |
| Trafficking of myristoylated proteins to the cilium 0 3 2.069674575957704 0.0384828291434962 |
| Hats acetylate histones 11 25 -2.068954295283192 0.0385503757997811 |
| Chl1 interactions 2 3 2.067741541709513 0.0386643333515495 |
| Glutathione conjugation 8 14 -2.066124162934402 0.038816757239148 |
| Rho gtpases activate cit 3 10 -2.06564532403707 0.0388619814689819 |
| Diseases of glycosylation 9 22 2.0610387643904766 0.0392993420174285 |
| Constitutive signaling by akt1 e17k in cancer 3 5 -2.060228349866145 0.0393767158995226 |
| Beta oxidation of decanoyl coa to octanoyl coa coa 4 6 -2.059509976098157 0.0394454103374788 |
| Phenylalanine and tyrosine metabolism 2 5 -2.0586880618975902 0.0395241305824183 |
| Citric acid cycle tca cycle 13 18 -2.0565163268660043 0.0397327741897783 |
| Activated ntrk2 signals through fyn 1 1 -2.0513774458886864 0.0402302037251014 |
| Ntrk2 activates rac1 1 1 -2.0513774458886864 0.0402302037251014 |
| Killing mechanisms 1 1 -2.0513774458886864 0.0402302037251014 |
| Signaling by notch2 1 2 2.049676411895304 0.0403960183202076 |
| Notch2 activation and transmission of signal to the nucleus 1 2 2.049676411895304 0.0403960183202076 |
| Purine ribonucleoside monophosphate biosynthesis 8 10 -2.0492148948063185 0.0404411062245986 |
| Negative epigenetic regulation of rrna expression 10 25 -2.0452310513815912 0.040832084549629 |
| Adrenaline noradrenaline inhibits insulin secretion 2 5 -2.043661450166699 0.0409870040454876 |
| Notch4 activation and transmission of signal to the nucleus 1 2 -2.042279000756729 0.0411238638898883 |
| Intra golgi and retrograde golgi to er traffic 27 87 2.041653490234669 0.0411859153335052 |
| Activation of smo 1 1 -2.0372318948071 0.0416268090493829 |
| Signaling by wnt 28 90 -2.0259664012103547 0.0427682278213574 |
| Glutamate and glutamine metabolism 4 8 -2.023501805577097 0.0430214376144499 |
| Transport of inorganic cations anions and amino acids oligopeptides 9 11 2.0167486917204256 0.0437217457845173 |
| Runx2 regulates osteoblast differentiation 3 3 -2.015670146439039 0.0438344793306688 |
| Cellular response to starvation 31 89 -2.0133082857636326 0.0440822072306772 |
| Aquaporin mediated transport 2 7 -2.0113276334011623 0.0442908615495596 |
| Rna polymerase i transcription 14 22 -2.0044760323478648 0.0450190918365485 |
| Downregulation of erbb4 signaling 0 1 2.003183514213572 0.0451575945079847 |
| Arachidonic acid metabolism 3 7 2.002416273639534 0.0452399796760656 |
| Interleukin 7 signaling 1 2 1.99288270357799 0.0462742927333716 |
| Extension of telomeres 15 33 -1.9863010053400607 0.046999911088857 |
| Met activates rap1 and rac1 2 5 -1.9849498381562647 0.0471500526803194 |
| Prevention of phagosomal lysosomal fusion 3 4 1.9832700779099528 0.0473372698318954 |
| Synthesis of diphthamide eef2 4 4 -1.982606734531232 0.0474113745433317 |
| Dopamine neurotransmitter release cycle 1 3 1.9805148094122875 0.0476457109375181 |
| Interleukin 6 family signaling 2 3 -1.975952476365312 0.048160159927725 |
| Interleukin 20 family signaling 2 3 -1.975952476365312 0.048160159927725 |
| Interleukin 6 signaling 2 3 -1.975952476365312 0.048160159927725 |
| Pcp ce pathway 18 51 -1.9727383808503052 0.0485253767545539 |
| Sema4d induced cell migration and growth cone collapse 2 7 -1.9671284742800508 0.049168401311312 |
| Smad2 smad3 smad4 heterotrimer regulates transcription 2 3 -1.959675062310576 0.0500337817232767 |
| Dna repair 35 116 -1.9547723363194087 0.0506099477338439 |
| Regulation of tp53 activity 22 54 -1.952051299354432 0.0509321143891665 |
| O linked glycosylation 2 5 1.9511266068790345 0.0510419868503866 |
| O linked glycosylation of mucins 2 5 1.9511266068790345 0.0510419868503866 |
| Trna processing in the mitochondrion 2 4 -1.9489163847118505 0.0513054110392723 |
| Transport of vitamins nucleosides and related molecules 4 7 1.9473715251927288 0.0514902093004172 |
| Gastrin creb signalling pathway via pkc and mapk 1 4 1.9437833860971545 0.0519215780590875 |
| Signal amplification 6 9 -1.9434253074304968 0.0519647919691386 |
| Depolymerisation of the nuclear lamina 4 8 1.9421049910600323 0.0521243914285343 |
| Dissolution of fibrin clot 1 2 -1.9412114382951895 0.0522326362811824 |
| Mitochondrial fatty acid beta oxidation of saturated fatty acids 4 8 -1.939043020222541 0.0524960999654697 |
| Caspase activation via death receptors in the presence of ligand 2 3 -1.934910295394461 0.0530013045940607 |
| Regulation by c flip 2 3 -1.934910295394461 0.0530013045940607 |
| Endosomal vacuolar pathway 3 4 1.933058786033837 0.0532289564223633 |
| Base excision repair 17 30 -1.9323550874160096 0.053315693445374 |
| Activation of bh3 only proteins 2 11 -1.9263376039017328 0.0540622329415187 |
| Metabolic disorders of biological oxidation enzymes 2 5 -1.9259888358506725 0.0541057678616372 |
| Caspase activation via extrinsic apoptotic signalling pathway 2 4 -1.9255510392893045 0.0541604571613973 |
| Gluconeogenesis 9 20 -1.923472237056525 0.0544207699051284 |
| Assembly of collagen fibrils and other multimeric structures 1 3 1.922314285002121 0.0545662236025064 |
| Stat3 nuclear events downstream of alk signaling 1 4 -1.9218954367162373 0.0546189161423793 |
| Met receptor recycling 3 5 -1.920079704062518 0.0548478325089396 |
| Telomere c strand synthesis initiation 1 3 -1.9161764476131224 0.0553426401886416 |
| Signaling by ctnnb1 phospho site mutants 1 5 -1.911882779377352 0.0558912309433434 |
| Disassembly of the destruction complex and recruitment of axin to the membrane 1 5 -1.911882779377352 0.0558912309433434 |
| Beta catenin phosphorylation cascade 1 5 -1.911882779377352 0.0558912309433434 |
| Telomere extension by telomerase 6 11 -1.910311459763724 0.0560931231417187 |
| Tp53 regulates transcription of death receptors and ligands 1 2 -1.9100590888478104 0.0561256057448318 |
| Lipophagy 1 3 1.9095633636462084 0.0561894560242528 |
| Cytochrome p450 arranged by substrate type 1 3 1.90682143971263 0.056543714028183 |
| Phosphate bond hydrolysis by nudt proteins 1 4 -1.9038180955252508 0.0569338789801181 |
| Dna methylation 3 4 -1.8915802180606065 0.0585469336423096 |
| Repression of wnt target genes 2 4 -1.88789832851456 0.059039600993429 |
| Diseases of signal transduction by growth factor receptors and second messengers 53 144 -1.886486012064594 0.0592294916137916 |
| Pyroptosis 1 3 -1.8760970807511164 0.060641950487712 |
| Sema4d in semaphorin signaling 3 9 -1.8716029217956889 0.061261558890354 |
| Nucleotide biosynthesis 8 12 -1.8692225557058888 0.0615918574278726 |
| P75ntr regulates axonogenesis 0 3 1.864483563550062 0.0622538276454909 |
| Diseases associated with glycosaminoglycan metabolism 1 4 1.8599084933755388 0.0628984734925426 |
| Miscellaneous transport and binding events 5 7 1.858886149713424 0.0630432776995182 |
| Defective intrinsic pathway for apoptosis 7 16 -1.856977628983403 0.0633143369140505 |
| Bmal1 clock npas2 activates circadian gene expression 0 3 1.856693796209252 0.0633547306396156 |
| Gaba b receptor activation 2 6 -1.8505628383971957 0.0642324700581777 |
| Adp signalling through p2y purinoceptor 12 2 6 -1.8505628383971957 0.0642324700581777 |
| G alpha z signalling events 2 6 -1.8505628383971957 0.0642324700581777 |
| Sirt1 negatively regulates rrna expression 3 4 -1.8498257129275224 0.0643386735932152 |
| Interleukin 23 signaling 1 2 1.848518121383028 0.0645274253392345 |
| Endogenous sterols 0 2 1.846320175601326 0.0648457299581886 |
| Resolution of abasic sites ap sites 16 29 -1.8392432640195835 0.0658794138431093 |
| Gdp fucose biosynthesis 2 3 -1.8390445884354127 0.0659086280966385 |
| Mrna decay by 5 to 3 exoribonuclease 5 9 -1.8357886998071693 0.066388913374523 |
| Rmts methylate histone arginines 6 19 -1.8330914049744664 0.0667889791000215 |
| Small interfering rna sirna biogenesis 1 4 -1.8316344048528177 0.0670059073899835 |
| Post translational modification synthesis of gpi anchored proteins 3 6 1.8302774620951656 0.0672084597636717 |
| Iron uptake and transport 7 17 1.8270419460537743 0.0676934628359673 |
| Infectious disease 64 339 -1.824550776281236 0.0680688473013706 |
| Processing of smdt1 6 11 1.8230663100261688 0.0682933484048264 |
| Pkmts methylate histone lysines 6 15 -1.8091895100043736 0.0704215667617425 |
| Rnd1 gtpase cycle 7 16 1.8035919611047844 0.0712952972318274 |
| Attachment of gpi anchor to upar 3 5 1.8035355258289656 0.0713041513437935 |
| Hdacs deacetylate histones 9 13 -1.7974355070571673 0.0722665080737123 |
| Degradation of beta catenin by the destruction complex 17 49 -1.7957281816034567 0.0725377575893413 |
| Apc c cdc20 mediated degradation of cyclin b 7 13 1.7828629140123724 0.0746086213522385 |
| Signaling by mapk mutants 2 2 -1.7811117697759882 0.0748941933517111 |
| Aggrephagy 3 13 -1.7779465483987962 0.0754126341360046 |
| Activation of the ap 1 family of transcription factors 2 2 -1.770012371832422 0.0767250797696286 |
| Gap junction assembly 2 3 -1.7687774794721864 0.0769310164343775 |
| Transport of connexons to the plasma membrane 2 3 -1.7687774794721864 0.0769310164343775 |
| Cargo concentration in the er 7 15 1.7687222891030494 0.0769402307566007 |
| Interleukin 9 signaling 1 2 -1.765971384591702 0.0774006497572479 |
| Interleukin 21 signaling 1 2 -1.765971384591702 0.0774006497572479 |
| Sumoylation of intracellular receptors 2 2 -1.762607756273033 0.0779666680099278 |
| Rhod gtpase cycle 12 27 1.7603557420816065 0.078347508416243 |
| Regulation of insulin secretion 3 14 -1.758805598412037 0.0786105335742264 |
| Fatty acid metabolism 14 59 -1.7555887191988298 0.0791586598004325 |
| Scavenging by class f receptors 2 4 -1.7547140867465671 0.0793082252719514 |
| Tcf dependent signaling in response to wnt 19 63 -1.751344155688094 0.0798866460792635 |
| Mapk3 erk1 activation 2 3 -1.741376995732577 0.0816175178342102 |
| Polb dependent long patch base excision repair 5 7 -1.7399231515199995 0.0818725128489781 |
| Cooperation of pdcl phlp1 and tric cct in g protein beta folding 2 14 -1.7386329999914665 0.0820993380383274 |
| Intraflagellar transport 2 11 -1.7343747394060254 0.0828516141060791 |
| Regulation of innate immune responses to cytosolic dna 0 2 1.7292278657363631 0.0837683209520681 |
| Ercc6 csb and ehmt2 g9a positively regulate rrna expression 8 12 -1.7291278244598498 0.0837862202860448 |
| G alpha s signalling events 2 8 -1.7283417263708218 0.0839269763453944 |
| Synthesis of pips at the late endosome membrane 1 4 -1.7255138421330392 0.0844349114099465 |
| Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation 1 3 1.7187977487370552 0.0856512056106679 |
| Synaptic adhesion like molecules 2 6 1.7077897052377555 0.0876753699721182 |
| Resolution of ap sites via the multiple nucleotide patch replacement pathway 14 23 -1.704501827572774 0.0882873749210322 |
| Smac xiap regulated apoptotic response 0 2 1.702908188916869 0.088585251314857 |
| Processing of capped intronless pre mrna 4 16 -1.69644678001914 0.0898013008845572 |
| Signaling by fgfr in disease 4 19 -1.6921551893540787 0.090616387918087 |
| Keratan sulfate keratin metabolism 5 6 1.6900633911550678 0.0910158277031074 |
| Glucose metabolism 10 60 -1.6895719855977442 0.0911098692361191 |
| Interconversion of nucleotide di and triphosphates 8 19 -1.688442535325942 0.0913263111664079 |
| Protein folding 17 37 -1.6871763590855835 0.0915694457687821 |
| Formation of apoptosome 0 3 1.6850036990479105 0.0919878578287733 |
| Processing of capped intron containing pre mrna 43 180 -1.6838216656705334 0.092216138788012 |
| Beta oxidation of octanoyl coa to hexanoyl coa 3 5 -1.673146427506328 0.0942984736595231 |
| Ephb mediated forward signaling 5 15 -1.6707187604150486 0.0947772415070906 |
| Gab1 signalosome 2 3 -1.6681726297089163 0.0952814625662337 |
| Dcc mediated attractive signaling 2 2 -1.667864806279442 0.0953425674485681 |
| Nef and signal transduction 2 2 -1.6641374466822747 0.096084965218536 |
| Rna polymerase i transcription initiation 12 19 -1.6592153859900247 0.0970723983016426 |
| Notch hlh transcription pathway 2 5 -1.655273605474992 0.0978690104542905 |
| Dna double strand break repair 24 57 -1.6542291370607862 0.0980809648244562 |
| Crmps in sema3a signaling 3 6 -1.6515378747685667 0.0986287936325422 |
| Other interleukin signaling 1 3 -1.6511475533408324 0.0987084492732115 |
| Polo like kinase mediated events 0 4 1.65023406338529 0.0988950723620396 |
| Displacement of dna glycosylase by apex1 3 4 -1.648558583659486 0.0992380994917123 |
| Initiation of nuclear envelope ne reformation 5 17 1.6436342306523968 0.100251778789518 |
| Nonhomologous end joining nhej 10 18 -1.6352527400096792 0.1019960762905851 |
| Complex i biogenesis 12 30 1.6346568383545426 0.1021210053105907 |
| B wich complex positively regulates rrna expression 12 18 -1.6307282410000277 0.1029476748188285 |
| Dna damage reversal 2 5 -1.6289213150326487 0.1033296771797507 |
| Pka mediated phosphorylation of creb 2 3 -1.624411512340188 0.1042880117106452 |
| Creb1 phosphorylation through the activation of adenylate cyclase 2 3 -1.624411512340188 0.1042880117106452 |
| Pka activation in glucagon signalling 2 3 -1.624411512340188 0.1042880117106452 |
| Synthesis of pi 0 2 1.6242504746481583 0.1043223623801956 |
| Base excision repair ap site formation 3 4 -1.6222683615958151 0.1047458998973658 |
| Pi3k akt signaling in cancer 5 11 -1.6204099629512374 0.1051442411251795 |
| Loss of function of mecp2 in rett syndrome 3 5 -1.6201074008727352 0.1052092079030795 |
| Free fatty acids regulate insulin secretion 0 2 1.6167013752807669 0.105942756921427 |
| The citric acid tca cycle and respiratory electron transport 30 92 1.6133089152186189 0.1066774106188488 |
| Opioid signalling 12 20 -1.609331997312743 0.107543766087065 |
| Immunoregulatory interactions between a lymphoid and a non lymphoid cell 4 5 1.6044714200087205 0.1086101792912492 |
| Type i hemidesmosome assembly 1 2 1.6016776592709905 0.1092269078993357 |
| Extra nuclear estrogen signaling 8 12 -1.6002513176859463 0.1095428418725292 |
| Stimuli sensing channels 3 8 1.5997414777491532 0.109655946269016 |
| Constitutive signaling by egfrviii 3 4 1.593859884323619 0.110967421179335 |
| Constitutive signaling by ligand responsive egfr cancer variants 3 4 1.593859884323619 0.110967421179335 |
| Signaling by egfr in cancer 3 4 1.593859884323619 0.110967421179335 |
| Synthesis of udp n acetyl glucosamine 4 5 -1.5911564361502453 0.1115743741643344 |
| Signaling by fgfr2 iiia tm 3 8 -1.5903907733268534 0.1117467488044772 |
| Fgfr2 mutant receptor activation 3 8 -1.5903907733268534 0.1117467488044772 |
| Adora2b mediated anti inflammatory cytokines production 6 10 -1.5853970389682055 0.112876153525014 |
| Meiotic recombination 8 12 -1.5838384477097704 0.113230487449079 |
| Insulin receptor recycling 3 9 1.5807344489248285 0.1139387681877017 |
| Conversion from apc c cdc20 to apc c cdh1 in late anaphase 6 11 1.5727355783306245 0.1157800580046597 |
| Interleukin 27 signaling 0 3 1.5716626769418205 0.116028802315693 |
| Interleukin 35 signalling 0 3 1.5716626769418205 0.116028802315693 |
| Formation of atp by chemiosmotic coupling 4 9 1.5710549486875762 0.1161698858620781 |
| Sumoylation of transcription cofactors 6 14 -1.5704574031105367 0.1163087369081543 |
| Fatty acyl coa biosynthesis 6 17 1.568460219950243 0.1167737666929795 |
| P38mapk events 0 2 1.567618485204057 0.1169701954726396 |
| Gaba receptor activation 2 7 -1.5665428971992397 0.1172215741667013 |
| Snrnp assembly 7 39 -1.5540321442191434 0.1201767493765415 |
| Purine catabolism 2 8 -1.5517133482937489 0.1207308273442531 |
| Membrane trafficking 82 230 1.549879861869515 0.1211703540029565 |
| Hedgehog off state 17 50 -1.5489719143743468 0.1213884717315199 |
| Nucleotide catabolism 2 10 -1.545766254386952 0.1221610296452526 |
| Esr mediated signaling 16 42 -1.5315761181794076 0.1256270695373873 |
| Signaling by fgfr2 in disease 3 10 -1.5273863238804073 0.1266649751655726 |
| Vesicle mediated transport 84 236 1.5264864524723545 0.1268887618281189 |
| Rnd2 gtpase cycle 6 16 1.524736241150525 0.1273248984909032 |
| Epha mediated growth cone collapse 2 10 -1.5245313352101075 0.12737603535266 |
| Synthesis of gdp mannose 2 4 -1.522102015687007 0.1279835210252282 |
| Visual phototransduction 2 8 -1.5211430498919611 0.128223943223799 |
| Hdr through mmej alt nhej 3 8 -1.5152519527430537 0.1297086109017184 |
| Signaling by nuclear receptors 12 56 -1.5105654396325134 0.1308992048491377 |
| Synthesis of pc 3 6 1.506364116672086 0.1319737270067562 |
| Ret signaling 3 6 -1.5046843429295975 0.1324052503380408 |
| Intra golgi traffic 4 14 1.4986479223812093 0.133964993515117 |
| Mrna capping 4 12 -1.497542435868564 0.1342521722891434 |
| Metabolism of steroid hormones 4 7 1.4827433415396487 0.1381426145996052 |
| Regulation of runx2 expression and activity 16 44 -1.4709812348125288 0.1412961917650079 |
| Prc2 methylates histones and dna 3 5 -1.4683837329762996 0.1420000177193261 |
| Anti inflammatory response favouring leishmania parasite infection 2 16 -1.4667543012831434 0.1424429052884246 |
| Raf activation 3 11 -1.4656831943252404 0.1427346146375663 |
| Darpp 32 events 5 9 -1.4656807173900497 0.1427352897465359 |
| Inactivation of csf3 g csf signaling 2 6 -1.4632456198679356 0.1434001818844628 |
| The role of gtse1 in g2 m progression after g2 checkpoint 15 49 -1.462340217068642 0.1436480029688533 |
| Irak1 recruits ikk complex 0 2 1.4612616767123026 0.1439436426981823 |
| Homology directed repair 19 41 -1.4572787493494668 0.145039450361921 |
| Syndecan interactions 2 4 1.4555960473619034 0.1455043213575426 |
| Beta oxidation of lauroyl coa to decanoyl coa coa 2 4 -1.452373510099199 0.1463977777776595 |
| Processing of dna double strand break ends 13 27 -1.4508141116077538 0.1468316291030378 |
| Glutamate neurotransmitter release cycle 1 3 -1.4474547533504585 0.1477696001697026 |
| Downstream signaling events of b cell receptor bcr 16 43 -1.4441099580564465 0.1487080473924065 |
| Regulation of tp53 activity through acetylation 8 12 -1.4391146010941056 0.15011805578929 |
| Mitochondrial trna aminoacylation 10 17 -1.43890581135754 0.1501772107919641 |
| Pentose phosphate pathway 5 7 -1.4384044119712138 0.1503193415343755 |
| Activation of ppargc1a pgc 1alpha by phosphorylation 1 2 1.4332573714869188 0.1517842994721245 |
| Cd163 mediating an anti inflammatory response 1 2 1.433257371486918 0.1517842994721248 |
| Neurotransmitter release cycle 3 8 -1.4332541261743017 0.1517852265750492 |
| Transcriptional regulation of white adipocyte differentiation 5 17 -1.4327657149365365 0.1519248023569148 |
| Transcriptional regulation by runx1 23 72 -1.4260573706937805 0.1538517825003382 |
| Nef mediated downregulation of mhc class i complex cell surface expression 1 3 1.4199150248182204 0.1556324212224873 |
| Protein methylation 5 7 -1.4144627155963063 0.1572260871527571 |
| Pten regulation 31 65 -1.410991186604533 0.1582472127614216 |
| Intracellular signaling by second messengers 40 85 -1.409716826267052 0.1586233142931599 |
| Translesion synthesis by y family dna polymerases bypasses lesions on dna template 12 22 -1.4071078679453095 0.1593954054074782 |
| Signaling by csf3 g csf 4 8 -1.4043967941307978 0.1602007250057324 |
| Carnitine metabolism 2 5 -1.403515052939408 0.1604633064086593 |
| Fanconi anemia pathway 4 7 -1.3959709996883962 0.1627232283112711 |
| Transcriptional regulation by runx2 17 52 -1.3933494474602093 0.1635141446717432 |
| Pre notch expression and processing 2 10 1.393161016837117 0.1635711051959243 |
| Tnfr2 non canonical nf kb pathway 16 43 -1.3870639698101668 0.1654222574394688 |
| Rrna processing in the mitochondrion 2 5 -1.3868961303956002 0.165473437984263 |
| Notch3 activation and transmission of signal to the nucleus 0 3 1.3815243765504588 0.1671177880208449 |
| Influenza infection 22 125 -1.3800172638160664 0.1675813294235335 |
| Formation of rna pol ii elongation complex 7 29 -1.3791960594846238 0.1678343126940149 |
| Antigen processing ubiquitination proteasome degradation 36 99 -1.37539328665331 0.1690095491572516 |
| Transferrin endocytosis and recycling 3 10 1.3649876407887844 0.1722569345657061 |
| Signaling by hedgehog 18 56 -1.357825186798747 0.1745191608684382 |
| Metabolism of porphyrins 1 8 1.3551873741373563 0.1753578663097865 |
| Platelet homeostasis 2 12 -1.351551710803199 0.1765187669592203 |
| Clec7a dectin 1 induces nfat activation 0 2 1.351332215918103 0.176589036602486 |
| Intrinsic pathway for apoptosis 3 19 -1.3500722473620417 0.1769928094603079 |
| Triglyceride metabolism 2 6 -1.3462139034670002 0.178233542451885 |
| Dna replication initiation 2 5 -1.345250213469083 0.1785444454486793 |
| Dscam interactions 3 3 -1.3432440703263406 0.1791929557683105 |
| Stabilization of p53 15 41 -1.342784111288446 0.1793418896808947 |
| Sensing of dna double strand breaks 0 4 1.3304828592491915 0.183359230189978 |
| Metabolism of polyamines 15 40 -1.3291116874997844 0.183811124921668 |
| Degradation of the extracellular matrix 5 10 -1.3282408816114646 0.1840985428716881 |
| Rac1 gtpase cycle 12 43 1.321027841223065 0.1864920811934538 |
| Runx1 regulates transcription of genes involved in differentiation of hscs 16 42 -1.3172133047173955 0.187767135432038 |
| Golgi cisternae pericentriolar stack reorganization 4 10 1.3138946180962614 0.1888816700988242 |
| Pregnenolone biosynthesis 2 5 1.310260267646869 0.1901078037407106 |
| G1 s dna damage checkpoints 15 42 -1.3061028221728317 0.1915175933772854 |
| Metalloprotease dubs 1 5 -1.3033153223342424 0.192467132137349 |
| Synthesis of ketone bodies 2 5 -1.3032058262193986 0.1925045015921143 |
| Ketone body metabolism 2 5 -1.3032058262193986 0.1925045015921143 |
| Purine salvage 0 4 1.2982964823479268 0.1941854747079934 |
| Fgfr2 alternative splicing 3 14 -1.2966826292068143 0.1947404086048585 |
| Regulation of pten stability and activity 15 43 -1.2955900948636974 0.1951167434559546 |
| Ros and rns production in phagocytes 2 8 1.293241543503146 0.1959275314613022 |
| Sumoylation of dna methylation proteins 4 4 -1.2821659827037453 0.1997844265236845 |
| Signaling by the b cell receptor bcr 16 46 -1.277864014239126 0.2012973784218292 |
| Interleukin 4 and interleukin 13 signaling 3 12 1.2772201267757477 0.2015245432233234 |
| Rho gtpases activate pkns 4 19 -1.2712261465876022 0.2036482073183525 |
| Hedgehog on state 14 42 -1.2688790860332675 0.2044841925606904 |
| Interleukin 3 interleukin 5 and gm csf signaling 3 7 -1.2669948635406665 0.2051571265194862 |
| Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3 3 4 -1.265995553559233 0.2055146741688158 |
| Prolonged erk activation events 2 5 -1.2647834268019964 0.2059489739994517 |
| Hyaluronan metabolism 2 4 1.2548247452994623 0.2095423875102056 |
| Hyaluronan uptake and degradation 2 4 1.2548247452994623 0.2095423875102056 |
| Rora activates gene expression 1 3 1.2544285644045976 0.2096862755566195 |
| Degradation of dvl 14 39 -1.2461928577001795 0.2126936005564883 |
| C type lectin receptors clrs 17 51 -1.2449707532830134 0.2131425010514656 |
| Nrif signals cell death from the nucleus 1 2 -1.2380456499244754 0.2156991346668166 |
| Transport to the golgi and subsequent modification 21 81 1.234195068417707 0.2171302246500737 |
| Striated muscle contraction 3 6 1.233315828964375 0.2174579545150929 |
| Dectin 1 mediated noncanonical nf kb signaling 15 42 -1.2313978644085768 0.2181740953207507 |
| Signaling by alk 1 5 -1.224786987439704 0.220655489044254 |
| Phase i functionalization of compounds 4 15 1.2208381374148922 0.2221473108944467 |
| Activated notch1 transmits signal to the nucleus 2 3 1.219449401739606 0.2226736692702098 |
| Degradation of axin 14 38 -1.2155123900147968 0.2241707261236512 |
| Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 16 53 -1.2084046364886565 0.2268916572551416 |
| Dap12 signaling 2 3 1.207192261491001 0.2273581099690182 |
| Cross presentation of soluble exogenous antigens endosomes 14 39 -1.2002375650571098 0.230047089951721 |
| Met promotes cell motility 2 6 -1.1990174857151754 0.2305211465616263 |
| Signaling by pdgf 3 6 -1.197753056346626 0.2310131674909334 |
| Downstream signal transduction 3 6 -1.197753056346626 0.2310131674909334 |
| Mecp2 regulates neuronal receptors and channels 3 7 -1.196131623819547 0.2316451985426919 |
| Degradation of gli1 by the proteasome 15 42 -1.1955409305652744 0.2318757544329486 |
| Pcna dependent long patch base excision repair 6 19 -1.1953172368677971 0.2319631077487018 |
| Copi mediated anterograde transport 14 56 1.195138010044962 0.2320331134217514 |
| Erks are inactivated 4 6 -1.1929810668023837 0.232876788103524 |
| Vitamin c ascorbate metabolism 1 3 1.189675923712919 0.2341737918755435 |
| Dual incision in tc ner 8 33 -1.1886716298596394 0.2345689086959494 |
| Unfolded protein response upr 5 43 1.1853801507152424 0.235867176154741 |
| Egr2 and sox10 mediated initiation of schwann cell myelination 0 4 1.1809788841749602 0.2376111118179666 |
| The phototransduction cascade 1 5 -1.180445832692152 0.2378229421906357 |
| Pexophagy 1 2 1.1801511734183447 0.2379400946379752 |
| Budding and maturation of hiv virion 5 5 -1.1782317199623316 0.2387042401558861 |
| Regulation of glycolysis by fructose 2 6 bisphosphate metabolism 2 4 -1.1781307180614045 0.2387444975017372 |
| Nephrin family interactions 4 7 1.1777462881703091 0.2388977674179959 |
| Regulation of tp53 activity through phosphorylation 13 33 -1.1748302315204875 0.2400626426559009 |
| Rnd3 gtpase cycle 10 20 1.1729531415261498 0.2408145971720556 |
| Asymmetric localization of pcp proteins 14 39 -1.1699487094636052 0.2420216101624368 |
| Alpha oxidation of phytanate 3 5 1.1615936745541382 0.2454005526797911 |
| Organelle biogenesis and maintenance 36 89 1.159899423165267 0.2460897576232132 |
| Basigin interactions 5 7 1.1570752853408186 0.2472416030892266 |
| Deadenylation of mrna 6 15 -1.156616474322344 0.2474290884668393 |
| Diseases of immune system 1 2 1.1549755983241474 0.2481004192391007 |
| Nuclear envelope ne reassembly 15 44 1.151305177629132 0.2496067078346724 |
| Phase 0 rapid depolarisation 1 2 -1.1475596454708146 0.2511503969883095 |
| Met activates ras signaling 2 4 -1.1442845956845402 0.2525056295948924 |
| Negative regulation of fgfr4 signaling 3 4 -1.1407418239871925 0.2539773763672392 |
| Negative regulation of fgfr2 signaling 3 4 -1.1407418239871925 0.2539773763672392 |
| Negative regulation of fgfr1 signaling 3 4 -1.1407418239871925 0.2539773763672392 |
| Spry regulation of fgf signaling 3 4 -1.1407418239871925 0.2539773763672392 |
| Negative regulation of fgfr3 signaling 3 4 -1.1407418239871925 0.2539773763672392 |
| E2f enabled inhibition of pre replication complex formation 2 5 1.1340287649263914 0.25678248225414 |
| Rna polymerase i promoter escape 8 13 -1.133629544751842 0.2569499745664707 |
| Suppression of apoptosis 3 4 -1.130786885293412 0.2581448011592484 |
| Zbp1 dai mediated induction of type i ifns 4 4 -1.1296964932348463 0.2586041353916946 |
| Rip mediated nfkb activation via zbp1 4 4 -1.1296964932348463 0.2586041353916946 |
| Auf1 hnrnp d0 binds and destabilizes mrna 14 42 -1.1295502978331358 0.2586657641264147 |
| Mapk6 mapk4 signaling 15 49 -1.1248843980985426 0.2606380241453105 |
| Formation of the beta catenin tcf transactivating complex 3 11 -1.1246219103088246 0.260749285099938 |
| Constitutive signaling by overexpressed erbb2 1 4 -1.1244749549188753 0.2608115895672662 |
| Coenzyme a biosynthesis 1 3 -1.1189413866135351 0.2631651452408796 |
| Sumo is conjugated to e1 uba2 sae1 2 3 1.1178942053202356 0.2636121802119207 |
| Sumo is transferred from e1 to e2 ube2i ubc9 2 3 1.1178942053202356 0.2636121802119207 |
| Processing and activation of sumo 2 3 1.1178942053202356 0.2636121802119207 |
| Formation of the cornified envelope 3 6 -1.117881026951645 0.2636178093088639 |
| Keratinization 3 6 -1.117881026951645 0.2636178093088639 |
| Gap junction degradation 2 6 -1.115823570681654 0.2644976623023587 |
| G2 m dna damage checkpoint 19 34 -1.1145148312089392 0.2650583854073887 |
| Pre notch processing in the endoplasmic reticulum 1 2 1.1123848384334958 0.26597272065165 |
| Beta oxidation of hexanoyl coa to butanoyl coa 2 5 -1.1110637607620155 0.2665409052173966 |
| Signalling to ras 2 3 1.110894077899811 0.266613944889456 |
| Termination of translesion dna synthesis 10 19 -1.110274532207684 0.2668807441004071 |
| Phase ii conjugation of compounds 15 28 -1.1088527570712143 0.2674937069881289 |
| Inactivation of cdc42 and rac1 3 3 -1.1075611063018629 0.268051408395511 |
| Cell surface interactions at the vascular wall 8 17 1.107496398823706 0.2680793684105533 |
| Signaling by ntrk2 trkb 2 5 -1.1044504403077595 0.2693977906735791 |
| Regulation of pten gene transcription 11 20 -1.1000224502620966 0.2713223403366005 |
| Phosphorylation of the apc c 7 13 1.0950653845046292 0.2734879924345357 |
| Establishment of sister chromatid cohesion 2 7 -1.094824489042529 0.2735935355464014 |
| Regulation of tp53 activity through methylation 3 6 -1.090078757316039 0.2756784528346916 |
| Carboxyterminal post translational modifications of tubulin 3 4 -1.0889854138921613 0.2761603179425738 |
| Interleukin 1 family signaling 16 50 -1.086813158574955 0.2771193912163918 |
| Rhoj gtpase cycle 7 24 1.0856775926317197 0.2776216575796424 |
| Regulation of ras by gaps 14 41 -1.085105872726297 0.2778747665828631 |
| Hedgehog ligand biogenesis 15 41 -1.0835614495446535 0.2785592912596475 |
| Synthesis of pips at the golgi membrane 2 8 1.0818157437398586 0.2793344095078922 |
| Clec7a dectin 1 signaling 16 47 -1.0796457307364546 0.2802999689402128 |
| Foxo mediated transcription 2 11 -1.0789319212623831 0.2806180774497657 |
| Rhot1 gtpase cycle 1 2 1.07563132865023 0.2820921704746495 |
| Dna damage bypass 13 25 -1.0709258717934431 0.2842027618465568 |
| Hdr through single strand annealing ssa 5 15 -1.0688150357994235 0.2851530227992773 |
| Homologous dna pairing and strand exchange 5 15 -1.0688150357994235 0.2851530227992773 |
| Signaling by erbb2 3 12 -1.0648558055676842 0.2869411868984721 |
| Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand 2 30 -1.0648215763147575 0.2869566792825861 |
| Insulin receptor signalling cascade 3 6 -1.0633484208218504 0.2876239742580124 |
| Flt3 signaling 3 5 -1.0610107912595956 0.2886849970352974 |
| Response of eif2ak1 hri to heme deficiency 1 5 -1.060784403754218 0.2887878916131381 |
| Transcriptional activity of smad2 smad3 smad4 heterotrimer 6 8 -1.0529476199145864 0.2923649993846207 |
| Downstream signaling of activated fgfr4 1 3 -1.0508875964315307 0.2933102177736157 |
| Downstream signaling of activated fgfr3 1 3 -1.0508875964315307 0.2933102177736157 |
| Downstream signaling of activated fgfr2 1 3 -1.0508875964315307 0.2933102177736157 |
| Downstream signaling of activated fgfr1 1 3 -1.0508875964315307 0.2933102177736157 |
| Regulation of runx3 expression and activity 13 38 -1.0507571430874412 0.2933701437735925 |
| Signal regulatory protein family interactions 0 3 1.0497023322142884 0.2938549911549935 |
| Runx1 regulates genes involved in megakaryocyte differentiation and platelet function 4 12 -1.0484427555548608 0.29443466349434 |
| Diseases of carbohydrate metabolism 4 9 1.0483789412863245 0.2944640519756074 |
| Signaling by met 6 17 -1.0473454367828992 0.2949402871540976 |
| Signalling to erks 2 8 -1.0392371029033116 0.2986944786933567 |
| Class i mhc mediated antigen processing presentation 41 124 -1.0379698131264543 0.299284109120705 |
| Recycling of eif2 gdp 8 8 -1.031692781780303 0.3022160599389467 |
| Dna damage telomere stress induced senescence 8 14 -1.0278904237286646 0.3040013746803667 |
| Transcriptional regulation by tp53 25 122 -1.0239196783920037 0.3058732146989531 |
| Translesion synthesis by polh 8 13 -1.023142215825282 0.3062406092516005 |
| Deactivation of the beta catenin transactivating complex 8 10 -1.0217020035746271 0.3069219625356292 |
| Cooperation of prefoldin and tric cct in actin and tubulin folding 10 15 -1.0136352269156332 0.3107568420563051 |
| Cellular responses to stimuli 53 328 -1.0047224930531753 0.3150304941283819 |
| Sensory perception 5 26 -1.0042765890857046 0.3152453145847715 |
| Wnt ligand biogenesis and trafficking 1 6 1.0016042924439787 0.3165347470258064 |
| Estrogen dependent nuclear events downstream of esr membrane signaling 2 3 -1.001560974730666 0.3165556770856608 |
| Er to golgi anterograde transport 19 79 0.9973873504114916 0.3185765289658586 |
| Cellular response to hypoxia 16 42 -0.9875146339461804 0.3233904124732232 |
| Inhibition of replication initiation of damaged dna by rb1 e2f1 3 6 -0.9865184955913188 0.3238787437176578 |
| Cdc42 gtpase cycle 9 32 0.985753717646546 0.3242539822686554 |
| Negative regulation of notch4 signaling 14 41 -0.9847501606035683 0.3247468071816934 |
| Signaling by notch4 14 44 -0.984606606035816 0.3248173435270567 |
| Negative regulation of mapk pathway 5 10 -0.9827093795780304 0.3257504930596102 |
| Constitutive signaling by aberrant pi3k in cancer 4 6 -0.9816686168560776 0.3262631311613306 |
| Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain 3 4 -0.9810594827198426 0.3265634093821685 |
| Rho gtpase effectors 15 109 -0.9801582867746644 0.3270079913590245 |
| Mapk family signaling cascades 25 89 -0.979435153801788 0.3273650146296258 |
| Molybdenum cofactor biosynthesis 2 3 -0.9733546140026282 0.3303770876886318 |
| Dap12 interactions 3 5 0.9730431301113396 0.3305318666817205 |
| Platelet calcium homeostasis 1 4 0.9721878064187413 0.3309571256014343 |
| Reduction of cytosolic ca levels 1 4 0.9721878064187413 0.3309571256014343 |
| Signaling by gpcr 11 48 0.971586256255104 0.3312564225965748 |
| Adaptive immune system 56 191 -0.9627344925927098 0.3356807822839391 |
| Hiv transcription elongation 6 22 -0.9623968241406466 0.3358503083719748 |
| Regulation of lipid metabolism by pparalpha 6 25 -0.9612873498720652 0.3364077066877924 |
| Translesion synthesis by polk 4 10 -0.9603362345926308 0.3368860191802423 |
| Maturation of sars cov 1 spike protein 1 4 0.9568385785331032 0.3386487368433366 |
| Hcmv early events 5 43 -0.9561690363656056 0.3389868406692753 |
| Circadian clock 4 12 -0.9555780218160016 0.3392854697229484 |
| G alpha i signalling events 9 26 -0.9506604704997236 0.3417767608800321 |
| Telomere c strand lagging strand synthesis 10 22 -0.95025570307024 0.3419823410364206 |
| Signaling by insulin receptor 3 15 0.9474356569047933 0.3434168287732313 |
| Degradation of cysteine and homocysteine 0 4 0.9437568316105622 0.3452939248577862 |
| Gap junction trafficking and regulation 6 10 -0.9417228224167472 0.3463345672998024 |
| Nucleotide excision repair 13 56 -0.9386342285964112 0.3479185726710372 |
| Processive synthesis on the lagging strand 7 14 -0.9313996841121523 0.3516468542204469 |
| Processing of intronless pre mrnas 10 14 -0.927414918036959 0.3537111480582973 |
| Gpvi mediated activation cascade 2 6 -0.926636969190304 0.3541150535285093 |
| Interleukin 1 signaling 15 48 -0.9233495587745862 0.3558250690721005 |
| Transcriptional regulation by runx3 13 42 -0.9232739253888868 0.355864472552849 |
| Glycolysis 7 48 -0.9220771597398726 0.3564883297331855 |
| Downregulation of smad2 3 smad4 transcriptional activity 5 6 -0.9215953494475952 0.3567396851794238 |
| Trans golgi network vesicle budding 12 33 0.9200004390588264 0.3575725297886762 |
| Cdt1 association with the cdc6 orc origin complex 14 41 -0.9199479775727096 0.3575999453745164 |
| Apc c mediated degradation of cell cycle proteins 17 61 -0.917825163883198 0.3587104058520762 |
| Signaling by scf kit 4 8 -0.911691168487885 0.3619313143281117 |
| Transmission across chemical synapses 11 45 -0.91077346999513 0.3624147437684188 |
| Golgi to er retrograde transport 19 70 0.9085642336809197 0.3635801932094358 |
| Apoptosis induced dna fragmentation 6 10 -0.9057577436320744 0.3650640915952334 |
| Fceri mediated nf kb activation 14 44 -0.9040865864090843 0.3659494904060891 |
| Signaling by notch1 pest domain mutants in cancer 2 7 -0.903676560222521 0.3661669316615275 |
| Sumoylation 35 81 -0.903556148896362 0.3662308023782228 |
| Hdr through homologous recombination hrr 11 24 -0.902207249743494 0.3669467843935017 |
| Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1 0 2 0.9012335006036104 0.3674641824618438 |
| Grb2 sos provides linkage to mapk signaling for integrins 1 2 -0.9008478864760812 0.3676692026965868 |
| Transcription of the hiv genome 7 28 -0.8998082222097374 0.3682223179835417 |
| Runx1 interacts with co factors whose precise effect on runx1 targets is not known 3 16 -0.8994264486931319 0.3684255565544974 |
| Diseases of mismatch repair mmr 1 3 0.8979865569984247 0.3691927163510298 |
| Traf3 dependent irf activation pathway 1 2 0.8967164244170956 0.3698702541574812 |
| Folding of actin by cct tric 5 8 -0.8962064223188385 0.3701425262600581 |
| Pp2a mediated dephosphorylation of key metabolic factors 3 3 -0.8927286853199103 0.3720024848774774 |
| Formation of tubulin folding intermediates by cct tric 8 11 -0.8916547655389286 0.3725780061439674 |
| Glycogen breakdown glycogenolysis 4 6 0.8904964757023153 0.3731993599604704 |
| Raf independent mapk1 3 activation 4 6 -0.8861753231373409 0.3755230589599936 |
| Downregulation of erbb2 signaling 2 7 -0.886030577100759 0.3756010504846874 |
| Rhof gtpase cycle 7 18 0.8856913080396991 0.3757838933865807 |
| Dna double strand break response 9 22 -0.8854004956970775 0.3759406651580592 |
| Hcmv infection 7 49 -0.885398766082404 0.3759415976833986 |
| Rab gefs exchange gtp for gdp on rabs 12 22 0.8819573098856178 0.377799893419263 |
| Fcgr activation 2 2 -0.8732880739244064 0.3825060793349113 |
| Fc epsilon receptor fceri signaling 15 52 -0.8714658509789185 0.3834998438431787 |
| Negative regulation of the pi3k akt network 6 11 -0.8680379093332053 0.3853735799192428 |
| Protein protein interactions at synapses 2 14 0.8664318714117535 0.3862533723009529 |
| Slc transporter disorders 14 34 0.8642926731631613 0.3874271340683517 |
| Cyclin a cdk2 associated events at s phase entry 14 44 -0.8623442220839952 0.3884981246255581 |
| Signaling by fgfr2 3 19 -0.8612456531056404 0.3891027608892927 |
| Signaling by fgfr 3 19 -0.8612456531056404 0.3891027608892927 |
| Rna polymerase i transcription termination 4 10 -0.8611157935610523 0.3891742715091528 |
| Activation of rac1 4 4 -0.8610505851459874 0.3892101832772465 |
| Antigen processing cross presentation 17 53 -0.8571804158154369 0.3913451840808128 |
| Nicotinate metabolism 0 4 0.8496635739248035 0.3955121557163867 |
| Transcription coupled nucleotide excision repair tc ner 9 45 -0.8459298722184339 0.3975918668339562 |
| Processive synthesis on the c strand of the telomere 7 12 -0.8425853601174833 0.3994603816064639 |
| Cell death signalling via nrage nrif and nade 2 12 -0.8416065555668842 0.400008218616275 |
| Tcr signaling 15 47 -0.8390228672833638 0.4014564775561102 |
| Response to elevated platelet cytosolic ca2 12 33 0.837873999908328 0.4021014725709799 |
| Activation of nmda receptors and postsynaptic events 3 22 0.8375243109012895 0.4022979176539996 |
| Rho gtpases activate nadph oxidases 5 5 -0.835770782350468 0.4032838664299829 |
| Inlb mediated entry of listeria monocytogenes into host cell 2 5 -0.8354398916922321 0.4034700770668973 |
| Metabolism of fat soluble vitamins 1 4 -0.8304836671319036 0.4062653784901822 |
| Downregulation of erbb2 erbb3 signaling 1 2 0.8301373926668433 0.406461107787802 |
| Neddylation 35 81 -0.8277363940649012 0.4078198033860603 |
| Defects in cobalamin b12 metabolism 3 4 0.8260190574707599 0.4087932812633965 |
| Cobalamin cbl vitamin b12 transport and metabolism 3 4 0.8260190574707599 0.4087932812633965 |
| Ionotropic activity of kainate receptors 1 2 0.8244585105135429 0.4096790808653092 |
| Nrcam interactions 1 2 0.8244585105135429 0.4096790808653092 |
| Dna replication pre initiation 28 63 -0.8220990217134266 0.4110205422357855 |
| Metabolism of carbohydrates 20 97 -0.8218555960618721 0.4111590874684392 |
| Cytokine signaling in immune system 44 178 -0.820831699516886 0.4117421396627529 |
| Sema3a pak dependent axon repulsion 1 7 -0.8174973695009529 0.4136442519372361 |
| Mitotic telophase cytokinesis 6 11 -0.8171560000816976 0.4138392836983338 |
| Cell cycle 65 298 -0.8131518617766494 0.4161309950651899 |
| Nuclear receptor transcription pathway 2 3 -0.8056249428400445 0.4204591391254006 |
| Alk mutants bind tkis 5 7 -0.8032843727525922 0.4218103882544257 |
| Wnt mediated activation of dvl 2 3 0.8022724574486537 0.4223953709080656 |
| Platelet activation signaling and aggregation 8 57 -0.8013218277640846 0.4229453574979205 |
| Cargo recognition for clathrin mediated endocytosis 16 35 0.8005373463645901 0.4233995346834152 |
| Aryl hydrocarbon receptor signalling 2 3 -0.7995793697504339 0.4239545442285317 |
| Inhibition of dna recombination at telomere 5 10 -0.7966927219860056 0.4256295118476796 |
| Met activates ptk2 signaling 1 2 -0.7875418887091054 0.4309647172154349 |
| Met interacts with tns proteins 1 2 -0.7875418887091054 0.4309647172154349 |
| Condensation of prophase chromosomes 5 11 -0.7839965129329894 0.4330421564221416 |
| Gene and protein expression by jak stat signaling after interleukin 12 stimulation 3 25 -0.7837270595748679 0.4332002811760849 |
| Glycogen synthesis 1 4 -0.7829636997545144 0.4336484290046605 |
| Formation of senescence associated heterochromatin foci sahf 6 9 -0.7818945898510247 0.4342765247784872 |
| Tp53 regulates transcription of dna repair genes 6 28 -0.7761294723333202 0.4376725434577846 |
| Separation of sister chromatids 23 106 -0.7758558068897279 0.4378341286822771 |
| Copii mediated vesicle transport 8 32 0.7745617703552865 0.4385986546524414 |
| Trna modification in the mitochondrion 3 7 -0.772841944468156 0.4396159264881463 |
| Dual incision in gg ner 12 24 -0.7721702545022026 0.4400135965522329 |
| Tysnd1 cleaves peroxisomal proteins 1 5 -0.7708626663148169 0.4407883380598627 |
| Signaling by cytosolic fgfr1 fusion mutants 6 8 -0.770145890628918 0.4412133567555583 |
| Miro gtpase cycle 2 5 0.7652958816942281 0.4440953758199604 |
| Plasma lipoprotein assembly remodeling and clearance 8 20 0.7643210582216498 0.4446759392330426 |
| Signaling by notch1 2 10 -0.7630307661690976 0.4454450477224188 |
| Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 1 10 0.7623733907438701 0.4458371829263647 |
| Death receptor signalling 7 27 -0.7623605887366123 0.4458448214848809 |
| Lagging strand synthesis 9 20 -0.7611018418953636 0.4465962404195762 |
| Association of tric cct with target proteins during biosynthesis 10 18 -0.7553267961498946 0.4500529244522977 |
| Regulation of mrna stability by proteins that bind au rich elements 16 63 -0.7521607572887997 0.4519543898719627 |
| Microrna mirna biogenesis 2 11 -0.7500277381457295 0.4532379989395543 |
| Tnfr1 induced nfkappab signaling pathway 4 6 -0.7498932677121404 0.4533189895007399 |
| Notch1 intracellular domain regulates transcription 2 7 -0.748436651905371 0.4541968218450716 |
| Scf skp2 mediated degradation of p27 p21 13 42 -0.7481565413580962 0.4543657408069825 |
| Copi independent golgi to er retrograde traffic 2 27 -0.7480012958435197 0.4544593759189936 |
| Interleukin 12 signaling 3 27 -0.7427461280237453 0.4576353967105346 |
| Sumoylation of transcription factors 5 6 -0.7376928470714292 0.4607011197617203 |
| Neurotransmitter receptors and postsynaptic signal transmission 2 36 -0.7375139487223153 0.4608098638190185 |
| Rab regulation of trafficking 15 31 0.7363100665395377 0.4615420213759498 |
| Cell cycle checkpoints 31 144 -0.7335369295588139 0.4632310125114505 |
| Ion homeostasis 7 12 0.7332516286112224 0.463404971511768 |
| Cardiac conduction 7 12 0.7332516286112224 0.463404971511768 |
| Collagen formation 4 12 0.7317112187355603 0.4643448474599552 |
| Regulation of ifna signaling 2 3 -0.7296687185047127 0.4655927064963858 |
| Synthesis of substrates in n glycan biosythesis 9 20 -0.7287167428242004 0.4661749490380824 |
| Ptk6 regulates rho gtpases ras gtpase and map kinases 0 3 0.7182712896220301 0.4725900290367906 |
| Transport of mature transcript to cytoplasm 19 61 -0.7159421920026854 0.4740270445512022 |
| Diseases associated with glycosylation precursor biosynthesis 4 9 -0.7154494920731792 0.4743313398780533 |
| Gap filling dna repair synthesis and ligation in gg ner 8 19 -0.7137202068109295 0.4754002088061055 |
| Acyl chain remodeling of cl 1 3 -0.7093591168073661 0.4781016514365124 |
| Tp53 regulates transcription of cell death genes 4 6 -0.7092529729690586 0.4781675058371322 |
| Incretin synthesis secretion and inactivation 1 5 0.7082341205176498 0.4787998805658375 |
| Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 1 5 0.7082341205176498 0.4787998805658375 |
| Deubiquitination 30 99 -0.7071393752117199 0.4794798687173336 |
| Suppression of phagosomal maturation 4 7 0.7011232029647432 0.4832261311882655 |
| Synthesis of active ubiquitin roles of e1 and e2 enzymes 6 9 -0.7000709942013789 0.4838829691105819 |
| 2 ltr circle formation 1 4 -0.699699466475763 0.4841150097368378 |
| Pyruvate metabolism 10 15 -0.6979558094079592 0.4852048304719139 |
| Regulation of hmox1 expression and activity 16 49 -0.695861367985866 0.4865156527799941 |
| Map3k8 tpl2 dependent mapk1 3 activation 1 4 -0.6943258451808798 0.4874778863593956 |
| Josephin domain dubs 1 2 -0.6914398565317984 0.4892891643561281 |
| Transcriptional regulation by mecp2 10 15 -0.690339687767241 0.4899805952100031 |
| Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 4 25 0.6897582663222949 0.4903462174674922 |
| G2 m checkpoints 28 86 -0.6895727139655865 0.4904629314667059 |
| N glycan trimming in the er and calnexin calreticulin cycle 4 15 0.6879611010713692 0.4914772775370664 |
| Tnfr1 induced proapoptotic signaling 2 3 -0.6850430207914359 0.4933167740163899 |
| Neutrophil degranulation 46 171 0.6828399150240098 0.4947080045774967 |
| Golgi associated vesicle biogenesis 11 25 0.6799154404716549 0.4965580043403559 |
| Cohesin loading onto chromatin 2 8 -0.6798640071473967 0.4965905736337246 |
| P75 ntr receptor mediated signalling 4 17 -0.6763660731133035 0.4988082520414092 |
| Hiv infection 21 129 -0.6756155162923299 0.4992847875387818 |
| Signaling by erbb2 ecd mutants 1 5 -0.6739765609966308 0.5003262154505528 |
| Signaling by erbb2 in cancer 1 5 -0.6739765609966308 0.5003262154505528 |
| Collagen biosynthesis and modifying enzymes 3 9 0.6729250531715585 0.5009949726504359 |
| Traf6 mediated irf7 activation 1 3 -0.6713743464459246 0.501982083202144 |
| Regulation of tp53 activity through association with co factors 1 2 0.6678704793155775 0.504216272719407 |
| Tp53 regulates transcription of genes involved in g1 cell cycle arrest 1 2 0.6678704793155775 0.504216272719407 |
| Transcriptional regulation by the ap 2 tfap2 family of transcription factors 4 6 -0.6654998113606189 0.5057308641635099 |
| Listeria monocytogenes entry into host cells 2 7 -0.6648798328206016 0.5061273557229908 |
| Interaction between l1 and ankyrins 2 3 0.6626765516975098 0.5075377304865563 |
| Hiv life cycle 14 73 -0.6598660173340883 0.5093398135197351 |
| Abc transporter disorders 15 44 -0.6592388201140298 0.5097424221616724 |
| Factors involved in megakaryocyte development and platelet production 10 42 -0.6588396383499734 0.5099987504894032 |
| Translation of sars cov 1 structural proteins 2 7 -0.6569905843034919 0.5111869707422749 |
| Map2k and mapk activation 7 11 -0.6521586514752463 0.5142988309511007 |
| Interleukin 2 family signaling 3 3 -0.6505344802028362 0.5153470369276993 |
| Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants 3 3 -0.6505344802028362 0.5153470369276993 |
| Defective cftr causes cystic fibrosis 15 43 -0.6479998398134492 0.5169850538864929 |
| G alpha q signalling events 2 12 -0.647537968986059 0.5172838291378477 |
| Creb1 phosphorylation through nmda receptor mediated activation of ras signaling 1 8 0.6455332298610836 0.5185816912080341 |
| Mtorc1 mediated signalling 3 11 -0.6447044851818035 0.5191187091910039 |
| Regulation of kit signaling 3 3 -0.6444895097109402 0.5192580579619916 |
| Prolactin receptor signaling 0 3 0.6431782813742133 0.5201084242650056 |
| Cd209 dc sign signaling 2 4 -0.6427127647048262 0.5204104967711034 |
| Rho gtpases activate formins 7 58 -0.6423662205555956 0.5206354270246569 |
| Selective autophagy 5 31 0.6418415906129514 0.5209760421144236 |
| Signaling by receptor tyrosine kinases 13 111 -0.6384544639689004 0.5231778869732444 |
| Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux 2 5 -0.6375340572293242 0.5237770333691252 |
| Mhc class ii antigen presentation 12 52 -0.6368036159417686 0.5242527704859041 |
| Leishmania infection 9 37 -0.6338069362076041 0.5262068259688879 |
| Mitotic g2 g2 m phases 22 86 -0.6302909982784677 0.5285042114187122 |
| Muscle contraction 12 26 0.6268531021205745 0.530755531260541 |
| Oxidative stress induced senescence 7 14 -0.6258931559057909 0.5313850239450317 |
| Tp53 regulates transcription of cell cycle genes 6 15 -0.6229687352523242 0.5333050674045168 |
| Gpcr ligand binding 2 11 -0.6170943917355916 0.5371724676278162 |
| Rhoh gtpase cycle 7 22 0.6142205237102091 0.5390696128610559 |
| Apoptosis 37 90 -0.6109039825587063 0.5412631481337618 |
| Platelet sensitization by ldl 3 5 -0.6089629669714104 0.5425489858968904 |
| Mrna decay by 3 to 5 exoribonuclease 4 15 -0.6004253778291045 0.5482227789667076 |
| Srp dependent cotranslational protein targeting to membrane 24 91 -0.5999276092125901 0.5485544813306389 |
| Mitotic spindle checkpoint 2 57 -0.5909230380720355 0.5545719889782612 |
| Non integrin membrane ecm interactions 2 5 0.5903920774391479 0.5549278208486994 |
| Meiosis 5 23 -0.5896697747887528 0.5554120627707237 |
| Reproduction 5 23 -0.5896697747887528 0.5554120627707237 |
| Ethanol oxidation 0 3 0.5883100325222876 0.5563242128111532 |
| Calnexin calreticulin cycle 2 8 0.5823322348078094 0.5603429168760647 |
| Tp53 regulates transcription of genes involved in g2 cell cycle arrest 4 8 -0.5818175745667304 0.5606895649258952 |
| Hiv elongation arrest and recovery 5 19 -0.581003580924948 0.5612380401201604 |
| Orc1 removal from chromatin 14 51 -0.5809974487786923 0.5612421729925545 |
| Mitotic metaphase and anaphase 28 136 -0.5775006467498198 0.5636013018529096 |
| Signaling by interleukins 11 107 -0.5737195834644842 0.5661575740116391 |
| Resolution of sister chromatid cohesion 2 59 -0.5686388418448661 0.5696012596875486 |
| Disinhibition of snare formation 0 2 0.563766384941224 0.5729131316699421 |
| Activation of gene expression by srebf srebp 2 19 -0.5634768429232866 0.5731102244158355 |
| Antiviral mechanism by ifn stimulated genes 13 51 -0.5630737917891925 0.5733846369405102 |
| Cellular response to chemical stress 24 77 -0.5607597937041482 0.574961299099638 |
| Receptor mediated mitophagy 1 4 -0.559156804659948 0.5760547098773505 |
| Mitotic prophase 18 59 0.5575767718280845 0.5771334215864248 |
| Mtor signalling 3 15 -0.556426643477453 0.5779192291894102 |
| Interleukin 12 family signaling 3 30 -0.5563431617685002 0.5779762863806917 |
| Tight junction interactions 1 2 0.5528929526982896 0.580336713389227 |
| Hsf1 activation 5 13 -0.5523383615079761 0.5807165525319642 |
| Cell extracellular matrix interactions 3 8 -0.5521606078689583 0.5808383205132048 |
| Negative regulators of ddx58 ifih1 signaling 3 8 -0.5464389491551149 0.5847642428733038 |
| Perk regulates gene expression 12 16 -0.5449278353010751 0.5858031511510307 |
| Pi metabolism 4 17 0.5410185298476251 0.5884948108306889 |
| Myogenesis 5 6 0.538328886741687 0.5903500119094658 |
| Tryptophan catabolism 0 2 0.536662674720274 0.5915006429322449 |
| Tak1 activates nfkb by phosphorylation and activation of ikks complex 2 5 0.5314643383316277 0.5950970473632511 |
| Beta oxidation of butanoyl coa to acetyl coa 1 4 -0.5310325518528626 0.595396221975536 |
| Sema3a plexin repulsion signaling by inhibiting integrin adhesion 3 3 -0.5306020614103629 0.5956945668928955 |
| Regulation of runx1 expression and activity 1 3 -0.5289078532503086 0.5968693738865471 |
| Hdms demethylate histones 5 9 -0.5280319150479148 0.5974771848743581 |
| Activation of nima kinases nek9 nek6 nek7 2 4 -0.5270497768584992 0.5981590221067299 |
| Nuclear envelope breakdown 13 40 0.5256474966442518 0.5991331494713092 |
| Regulation of cholesterol biosynthesis by srebp srebf 5 27 0.5233571007921726 0.60072577164234 |
| Peptide hormone metabolism 6 14 0.518928358237391 0.6038107013623195 |
| S phase 24 98 -0.5181885517772888 0.6043267215079511 |
| Host interactions of hiv factors 23 94 -0.5135408217981046 0.6075730631806453 |
| Signaling by notch 17 61 -0.5126455759165924 0.6081992662534124 |
| Programmed cell death 39 99 -0.5123509211665414 0.6084054330945565 |
| Nuclear signaling by erbb4 1 4 -0.5079551732320569 0.6114847804629411 |
| Peroxisomal protein import 4 22 -0.5065258307586269 0.6124875609718419 |
| Translation of sars cov 2 structural proteins 6 18 0.5015990669667637 0.6159495758614408 |
| Mitotic g1 phase and g1 s transition 30 78 -0.4993960973785755 0.6175003679789013 |
| Dna damage recognition in gg ner 8 18 0.498688237011515 0.6179990326868432 |
| Sting mediated induction of host immune responses 1 5 0.4938815372348158 0.6213898443069876 |
| Irf3 mediated induction of type i ifn 1 5 0.4938815372348158 0.6213898443069876 |
| Trna processing in the nucleus 7 40 -0.4898932515779334 0.6242094386347568 |
| Sialic acid metabolism 0 4 0.4888885585709487 0.6249205963269602 |
| Energy dependent regulation of mtor by lkb1 ampk 4 7 0.4844542622249433 0.6280635167387907 |
| Heme biosynthesis 3 4 -0.4836487259138323 0.6286351879284091 |
| Signaling by rho gtpases miro gtpases and rhobtb3 64 247 0.4823581380797018 0.6295515536234713 |
| Rhoc gtpase cycle 10 32 0.4796694548216826 0.631462450801068 |
| Signaling by ntrks 4 31 -0.4796346657895426 0.6314871921964331 |
| Rhobtb3 atpase cycle 1 4 -0.4785705700698578 0.6322441591361487 |
| Regulation of mecp2 expression and activity 3 11 -0.4738372323769479 0.63561598178911 |
| Dna replication 22 93 -0.473182082851996 0.6360832794422417 |
| Fgfr1 mutant receptor activation 1 10 -0.4706257840905902 0.6379079914862731 |
| Ras processing 1 4 0.469579181288473 0.6386557014927843 |
| Wnt5a dependent internalization of fzd2 fzd5 and ror2 2 8 -0.4695171275112179 0.6387000452659493 |
| Signaling by hippo 1 6 -0.4690625872118177 0.639024900202225 |
| Sars cov 1 infection 4 11 -0.464645237740554 0.6421855308279916 |
| Synthesis of dna 20 87 -0.4613683059870259 0.6445343863651107 |
| Mitotic prometaphase 2 88 -0.4587849133422082 0.6463886296839629 |
| Smooth muscle contraction 1 11 -0.4539746281396596 0.6498470883324672 |
| Diseases of mitotic cell cycle 9 17 0.4533816753852425 0.650273929267656 |
| Trna processing 28 64 -0.4525510933230975 0.650872022163755 |
| Irs mediated signalling 1 4 -0.449226533676678 0.6532682485180958 |
| Oncogenic mapk signaling 5 28 -0.4469947974970719 0.6548788162343395 |
| Switching of origins to a post replicative state 14 61 -0.4446225225819266 0.6565925682933413 |
| Caspase mediated cleavage of cytoskeletal proteins 2 7 -0.4441287697725469 0.6569494872656971 |
| Runx2 regulates bone development 3 4 -0.4433195896327229 0.6575345883427741 |
| Transcriptional activation of mitochondrial biogenesis 3 14 -0.4430020726429328 0.6577642355410913 |
| Recognition of dna damage by pcna containing replication complex 9 19 -0.4426151328127013 0.6580441371421233 |
| Signaling by moderate kinase activity braf mutants 7 13 -0.4418278013341655 0.6586138190028281 |
| Rhob gtpase cycle 2 25 -0.4400822316437013 0.6598775505054562 |
| Wnt5a dependent internalization of fzd4 2 9 -0.4391102393015579 0.6605816601692438 |
| Ion transport by p type atpases 1 12 -0.4375427910838665 0.6617177500706237 |
| Synthesis of pips at the er membrane 0 3 0.4360338389876381 0.6628121782195309 |
| Interferon signaling 13 65 -0.4357042086462266 0.6630513518055836 |
| Inositol phosphate metabolism 1 8 -0.4352863957096599 0.6633545583913913 |
| Ticam1 rip1 mediated ikk complex recruitment 2 3 0.4316700678569872 0.6659812250752912 |
| Ikk complex recruitment mediated by rip1 2 3 0.4316700678569872 0.6659812250752912 |
| Regulation of tnfr1 signaling 3 7 -0.431633615971924 0.6660077223043717 |
| Signaling by fgfr4 3 5 -0.4289433636725173 0.6679644416942023 |
| Signaling by fgfr3 3 5 -0.4289433636725173 0.6679644416942023 |
| Signaling by fgfr1 3 5 -0.4289433636725173 0.6679644416942023 |
| Dag and ip3 signaling 1 8 0.4257358538898746 0.6703003331400372 |
| Gene silencing by rna 7 46 -0.4158492262612145 0.6775203350278038 |
| Cyclin a b1 b2 associated events during g2 m transition 0 10 0.4157429890720447 0.6775980804502011 |
| Alpha linolenic omega3 and linoleic omega6 acid metabolism 1 6 -0.4154078645546898 0.6778433503735786 |
| Late endosomal microautophagy 2 6 -0.4139840841814297 0.6788857629073077 |
| Post chaperonin tubulin folding pathway 5 9 -0.4133700494570799 0.6793355146543922 |
| Signaling by fgfr1 in disease 1 11 -0.4120400283504821 0.6803100842687262 |
| Signaling by pdgfr in disease 2 5 -0.408302049713999 0.6830519346559503 |
| Pecam1 interactions 2 4 -0.4068848394442339 0.6840925713275134 |
| Methionine salvage pathway 3 4 -0.4002378373125435 0.6889813483525333 |
| Tbc rabgaps 7 13 0.3990051846676843 0.6898893840263423 |
| Atf4 activates genes in response to endoplasmic reticulum stress 2 13 -0.3978025269472172 0.690775754437343 |
| Early phase of hiv life cycle 2 7 -0.3895428405543124 0.6968746260600449 |
| Gamma carboxylation hypusine formation and arylsulfatase activation 4 12 0.3875444952399457 0.6983531509731988 |
| L1cam interactions 3 39 -0.3863030214862541 0.699272263040063 |
| Sumoylation of dna damage response and repair proteins 4 49 -0.3855378813324392 0.6998389462040293 |
| Abortive elongation of hiv 1 transcript in the absence of tat 3 12 -0.3796457795578226 0.704208373425891 |
| Neurexins and neuroligins 6 9 -0.3781607550639142 0.7053111773869749 |
| Notch3 intracellular domain regulates transcription 1 3 -0.377535804769053 0.7057754612274865 |
| Rhoq gtpase cycle 1 25 -0.3767146466204285 0.7063856770033188 |
| Negative regulation of met activity 2 7 -0.3755277410650383 0.7072680191007479 |
| Ksrp khsrp binds and destabilizes mrna 10 14 -0.3753465712646542 0.7074027348277321 |
| Glutathione synthesis and recycling 6 6 -0.3732919739343336 0.7089311493216663 |
| Aberrant regulation of mitotic exit in cancer due to rb1 defects 6 12 0.3677123422059677 0.7130877366315338 |
| Sars cov 2 infection 6 22 0.3626051552252601 0.7168998587067561 |
| Formation of the early elongation complex 3 14 -0.3618390601102565 0.7174723013428943 |
| Global genome nucleotide excision repair gg ner 8 43 -0.3583749832068479 0.7200627105801263 |
| Cytochrome c mediated apoptotic response 0 4 0.3558638481812881 0.7219425307763079 |
| Metabolism of folate and pterines 2 10 0.3525441955277311 0.7244301799467663 |
| Cellular senescence 14 41 -0.3524438403283589 0.7245054286384285 |
| Ovarian tumor domain proteases 8 11 -0.3474969231997376 0.7282180295999485 |
| Polymerase switching on the c strand of the telomere 5 15 -0.3460912591342691 0.7292741321999743 |
| Anchoring of the basal body to the plasma membrane 11 26 0.3435564282793349 0.7311798973486687 |
| Signaling by kit in disease 5 5 -0.3425850549163758 0.7319106468737191 |
| Bbsome mediated cargo targeting to cilium 4 7 -0.3317118022652726 0.740106887902279 |
| Autophagy 8 45 0.3315959922429368 0.7401943462455534 |
| Beta oxidation of pristanoyl coa 0 4 0.3311640509690139 0.7405205727438224 |
| Polymerase switching 5 14 -0.3291902270912071 0.742011909317547 |
| Viral messenger rna synthesis 4 34 -0.3280480718537678 0.7428753158437851 |
| Signaling by alk in cancer 12 34 -0.3276272205871645 0.7431935378795829 |
| Generation of second messenger molecules 2 4 -0.3264336268575573 0.7440962991290516 |
| Costimulation by the cd28 family 14 14 -0.3251747528227933 0.7450488155821988 |
| Transcriptional regulation by small rnas 4 37 -0.3233176715233304 0.7464546721546479 |
| Integration of provirus 1 5 -0.3214817244630552 0.7478453596090355 |
| Transport of mature mrnas derived from intronless transcripts 4 36 -0.3095264993074734 0.7569210576552159 |
| Nucleotide salvage 0 7 0.3060115007615452 0.759595889226107 |
| Interactions of vpr with host cellular proteins 10 33 0.3052583904261766 0.7601693640351892 |
| Assembly and cell surface presentation of nmda receptors 10 10 -0.3051637380457133 0.7602414488044738 |
| Sumoylation of chromatin organization proteins 3 37 -0.3049866467962875 0.7603763224448445 |
| Activation of the pre replicative complex 3 20 0.3025600972918403 0.7622251276309882 |
| Vxpx cargo targeting to cilium 1 8 -0.3004084676341775 0.763865605562495 |
| Sumoylation of dna replication proteins 5 36 -0.2972280429600136 0.7662924135825995 |
| Transport of the slbp dependant mature mrna 4 31 -0.2954595598326798 0.7676428406560489 |
| Ctla4 inhibitory signaling 3 7 -0.2919950726199368 0.7702903913691037 |
| Erk mapk targets 1 9 0.2891666699444709 0.7724538363450519 |
| Mapk targets nuclear events mediated by map kinases 1 9 0.2891666699444709 0.7724538363450519 |
| Post translational protein modification 96 418 0.2879509220811299 0.7733843066786146 |
| Resolution of d loop structures through synthesis dependent strand annealing sdsa 2 7 -0.2866387586531 0.7743889340175312 |
| Resolution of d loop structures 2 7 -0.2866387586531 0.7743889340175312 |
| Estrogen dependent gene expression 4 29 -0.2816110350761448 0.7782417777717452 |
| Antigen presentation folding assembly and peptide loading of class i mhc 3 16 0.2714854206964976 0.7860177113989553 |
| Eph ephrin mediated repulsion of cells 1 13 -0.2714480141157351 0.7860464778036655 |
| Signaling by egfr 3 12 -0.2705319368473728 0.7867510505226929 |
| Fceri mediated mapk activation 7 7 -0.2687166590723716 0.7881477310776428 |
| Trafficking of ampa receptors 5 10 -0.2659382791781886 0.7902867437334444 |
| Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10 3 4 0.2624779020443955 0.7929530199060644 |
| Vitamin b5 pantothenate metabolism 1 6 -0.2590799274160781 0.7955735717796517 |
| Nrage signals death through jnk 1 8 -0.2583990840206476 0.7960989234467666 |
| Cd28 co stimulation 8 9 0.2573268779303456 0.7969264453000713 |
| Regulation of ifng signaling 2 4 -0.2571835906601039 0.7970370508222067 |
| Endosomal sorting complex required for transport escrt 4 6 -0.257171753787251 0.797046188058339 |
| Rho gtpases activate iqgaps 7 8 0.2559556351412693 0.797985094420667 |
| Toll like receptor tlr1 tlr2 cascade 5 18 0.2544960000284897 0.7991123939066713 |
| Sulfur amino acid metabolism 6 10 -0.2539038200573993 0.7995698635048591 |
| Butyrate response factor 1 brf1 binds and destabilizes mrna 2 12 -0.2532937090950488 0.8000412570569813 |
| Ldl clearance 1 14 -0.2518436479609092 0.8011619181958016 |
| Jnk c jun kinases phosphorylation and activation mediated by activated human tak1 2 3 0.2506963172147932 0.8020489082124092 |
| Rho gtpases activate wasps and waves 3 15 -0.2478879504339369 0.8042211031596511 |
| Rhobtb2 gtpase cycle 4 20 -0.2451315023643865 0.8063546115301528 |
| Toll like receptor 9 tlr9 cascade 5 19 0.2435287056634322 0.8075958504234237 |
| Tnf signaling 3 9 -0.2412777204174932 0.809339877406384 |
| Response of mtb to phagocytosis 3 13 -0.2407228167284724 0.8097699537068697 |
| Infection with mycobacterium tuberculosis 3 13 -0.2407228167284724 0.8097699537068697 |
| Nr1h2 and nr1h3 mediated signaling 0 7 0.2370010208424117 0.812655998300287 |
| Cytosolic sulfonation of small molecules 0 5 0.2364219860918519 0.8131052372644065 |
| Signaling by retinoic acid 3 9 -0.2358937688726038 0.8135151035459909 |
| Cytosolic sensors of pathogen associated dna 8 17 -0.2338512959148597 0.8151004250648433 |
| Recruitment of mitotic centrosome proteins and complexes 8 28 0.233105740139215 0.8156792976910539 |
| Uptake and function of diphtheria toxin 2 4 -0.2320634292990041 0.8164887487387218 |
| Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 5 7 -0.2308747179282782 0.8174121323329704 |
| Long term potentiation 5 5 -0.2300146765852892 0.818080365189398 |
| Ras activation upon ca2 influx through nmda receptor 5 5 -0.2300146765852892 0.818080365189398 |
| Unblocking of nmda receptors glutamate binding and activation 5 5 -0.2300146765852892 0.818080365189398 |
| Cell junction organization 3 19 -0.2258744060576008 0.8212991044336051 |
| Plasma lipoprotein clearance 6 16 0.2247041345643202 0.8222094479437352 |
| Signaling by type 1 insulin like growth factor 1 receptor igf1r 5 5 -0.2240500591578084 0.822718351608501 |
| Ephrin signaling 4 5 0.2199704260387476 0.8258941872018457 |
| Cd28 dependent vav1 pathway 4 5 0.21997042603872 0.8258941872018672 |
| Hsf1 dependent transactivation 15 15 -0.2147593337119311 0.8299549600706948 |
| Tristetraprolin ttp zfp36 binds and destabilizes mrna 2 13 -0.2142626814544516 0.8303422181140114 |
| Apoptotic cleavage of cell adhesion proteins 1 6 -0.2119015166638209 0.8321838673383952 |
| Hemostasis 30 122 0.2104898777299964 0.8332853511060323 |
| Regulation of bach1 activity 0 4 0.2089642301859481 0.8344761623292318 |
| Activation of ampk downstream of nmdars 4 5 0.208904422915014 0.8345228513535572 |
| Binding and uptake of ligands by scavenger receptors 2 6 -0.2081922423707047 0.835078865577388 |
| Signaling by flt3 fusion proteins 4 5 0.2049284052583628 0.8376280619724095 |
| Signaling by ptk6 3 10 0.2048008860925023 0.8377276946858596 |
| Sensory processing of sound 4 18 -0.2040462399629398 0.8383173646896795 |
| Toll like receptor cascades 6 24 0.2031068232037067 0.8390515387381743 |
| Signaling by notch3 0 6 0.2029667453690717 0.8391610245434298 |
| Cargo trafficking to the periciliary membrane 7 19 0.2027040470035955 0.8393663597956973 |
| Aspartate and asparagine metabolism 2 5 -0.2025318352324014 0.8395009731434666 |
| Ddx58 ifih1 mediated induction of interferon alpha beta 4 17 -0.2021896564356998 0.8397684591103669 |
| G protein mediated events 7 11 -0.2017950807802689 0.8400769274095143 |
| G0 and early g1 3 5 -0.1948542104710938 0.8455070817537527 |
| Egfr downregulation 1 8 -0.1940483149154765 0.8461380510011416 |
| Translocation of slc2a4 glut4 to the plasma membrane 13 31 0.193998900406534 0.8461767428963303 |
| Ncam signaling for neurite out growth 5 5 -0.193535243972335 0.8465398070803178 |
| Signaling by erbb4 1 7 -0.189820993234428 0.8494494047543659 |
| Lysosome vesicle biogenesis 4 13 0.1887400670911294 0.8502965469258845 |
| Synthesis of ip2 ip and ins in the cytosol 4 5 0.1854401389937199 0.8528838279735464 |
| Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 5 9 0.1816158972943362 0.8558841720999428 |
| Deposition of new cenpa containing nucleosomes at the centromere 1 8 -0.1787980823030925 0.8580962511202617 |
| Rap1 signalling 2 3 -0.1688494498547135 0.865915061334926 |
| Extracellular matrix organization 9 30 0.16370899031531 0.8699602397912429 |
| Methylation 4 7 -0.162835432336024 0.870648009607192 |
| Kinesins 16 16 -0.1614447242913052 0.8717431437586702 |
| Diseases of dna repair 2 11 -0.1596632777910418 0.8731463298069457 |
| Heme signaling 0 8 0.1591524817935468 0.8735487406196896 |
| Transcriptional regulation of granulopoiesis 3 7 -0.1570960793583444 0.8751691274370861 |
| Nuclear events stimulated by alk signaling in cancer 4 11 -0.1563180066580541 0.8757823635507263 |
| Interferon gamma signaling 14 14 -0.1560584616926397 0.8759869398949272 |
| Mismatch repair 5 13 -0.153789325129862 0.8777758510149218 |
| Attenuation phase 10 10 -0.153757487010133 0.8778009555829467 |
| Integrin signaling 3 4 0.1521337035714443 0.8790814819847386 |
| Platelet aggregation plug formation 3 4 0.1521337035714443 0.8790814819847386 |
| Metabolism of cofactors 2 5 0.1518308935458415 0.8793203150807083 |
| G1 s specific transcription 2 10 0.1514112727791862 0.8796512975895516 |
| Apoptotic cleavage of cellular proteins 2 18 0.1477018067236939 0.8825781057185469 |
| Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol 1 3 -0.1476711872740148 0.8826022715186341 |
| Regulation of tp53 expression and degradation 11 11 -0.1452468582013168 0.8845159706750176 |
| Signal transduction by l1 6 11 -0.1447276537514775 0.8849259044901181 |
| Cytoprotection by hmox1 10 68 0.1434747218608306 0.8859152737249456 |
| Peroxisomal lipid metabolism 5 12 0.1395166055957737 0.8890419348990541 |
| Condensation of prometaphase chromosomes 10 10 -0.1362644432439318 0.8916122318332025 |
| Insulin processing 3 8 0.1324446695112938 0.8946325846929748 |
| Netrin 1 signaling 8 8 -0.1324396240992923 0.8946365751968284 |
| Phosphorylation of emi1 0 4 0.1290641617624255 0.8973068795493473 |
| Retrograde neurotrophin signalling 8 8 -0.1277928383265142 0.8983129177811318 |
| Assembly of the orc complex at the origin of replication 5 8 -0.1267914424318328 0.8991054690229099 |
| Activated tak1 mediates p38 mapk activation 3 4 0.1258934556513211 0.8998162630934106 |
| Uptake and actions of bacterial toxins 4 8 -0.1227726796764454 0.9022871090208802 |
| Rna polymerase iii transcription initiation from type 3 promoter 3 5 -0.1200451208041102 0.9044474051403126 |
| Rna polymerase iii chain elongation 3 5 -0.1200451208041102 0.9044474051403126 |
| Vldlr internalisation and degradation 7 7 -0.118974953018515 0.9052951994101096 |
| Trafficking of glur2 containing ampa receptors 6 6 -0.1105980839588649 0.9119350669451844 |
| Nod1 2 signaling pathway 5 6 -0.1083809593177241 0.9136935044211962 |
| Oncogene induced senescence 7 7 -0.1063315993621931 0.9153192610361258 |
| Glycogen metabolism 5 9 0.1024578067832464 0.9183933018544984 |
| E3 ubiquitin ligases ubiquitinate target proteins 1 17 0.1005306605801381 0.919923042505463 |
| Mastl facilitates mitotic progression 4 5 0.0999828524892102 0.920357938953795 |
| Biological oxidations 7 44 0.0965731060750362 0.9230654148850084 |
| Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects 4 4 -0.0954041151225471 0.9239938475947598 |
| Chaperone mediated autophagy 3 7 0.0927480192090727 0.9261037475794872 |
| Ca dependent events 0 7 0.0882792907397858 0.9296546982801104 |
| Hur elavl1 binds and stabilizes mrna 3 4 0.0873655632660984 0.9303809412162658 |
| Dna strand elongation 5 30 0.0865541871440367 0.931025882534033 |
| Senescence associated secretory phenotype sasp 10 22 0.085576384282045 0.9318031721897816 |
| Fceri mediated ca 2 mobilization 0 5 0.0786855639947463 0.9372827281387712 |
| Sars cov infections 11 60 0.0730443588922667 0.941770818473926 |
| Cilium assembly 19 55 0.0684237910382139 0.9454482836986828 |
| Piwi interacting rna pirna biogenesis 3 9 0.0621048027868472 0.9504793723130248 |
| Aurka activation by tpx2 8 27 0.0592885152942774 0.95272230849153 |
| Regulation of plk1 activity at g2 m transition 9 30 0.0540174691828747 0.9569212461658472 |
| The role of nef in hiv 1 replication and disease pathogenesis 5 11 0.0510556504029265 0.9592811757234384 |
| Activation of atr in response to replication stress 3 20 0.0490653082616914 0.9608672500894336 |
| Retrograde transport at the trans golgi network 3 13 0.047827396793099 0.9618538020524252 |
| Apoptotic factor mediated response 0 6 0.0473697113768365 0.962218568730682 |
| Myd88 independent tlr4 cascade 3 19 0.0459001723330831 0.9633898168215884 |
| Hiv transcription initiation 3 14 0.0404680031942184 0.967720015887792 |
| Nuclear events kinase and transcription factor activation 1 12 0.0376748202816242 0.9699469522440702 |
| Recruitment of numa to mitotic centrosomes 8 32 0.0350238523036921 0.9720607211507228 |
| Fcgamma receptor fcgr dependent phagocytosis 3 27 0.0349159097414108 0.9721467942094332 |
| Amyloid fiber formation 0 6 0.0349147597674332 0.9721477111968042 |
| Ripk1 mediated regulated necrosis 4 12 0.0344692272036581 0.972502980893847 |
| Synthesis of pips at the early endosome membrane 0 6 0.0339596358767818 0.9729093380254844 |
| Vegfr2 mediated vascular permeability 9 10 0.0231341130908938 0.9815432946502984 |
| Negative regulation of nmda receptor mediated neuronal transmission 5 6 0.0214745825098456 0.9828670790055496 |
| Cell cell junction organization 8 9 0.0158165760074202 0.987380724349348 |
| Recycling pathway of l1 5 19 0.0141993030061648 0.9886709760518552 |
| Regulation of glucokinase by glucokinase regulatory protein 11 27 0.0119037747025905 0.990502386251801 |
| Adherens junctions interactions 6 7 0.0085659172101386 0.9931654704895464 |
| Growth hormone receptor signaling 4 5 0.0076362781446104 0.9939071907812138 |
| Apc cdc20 mediated degradation of nek2a 6 14 0.007472315846623 0.9940380100343744 |
| Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components 6 14 0.007472315846623 0.9940380100343744 |
| Traf6 mediated nf kb activation 2 6 0.000735002614963 0.999413552814174 |
| Cellular response to heat stress 18 61 0.0 1.0 |
| Regulated necrosis 6 15 0.0 1.0 |
| Regulation of hsf1 mediated heat shock response 16 52 0.0 1.0 |
| Nuclear pore complex npc disassembly 11 30 0.0 1.0 |
| Sumoylation of ubiquitinylation proteins 11 28 0.0 1.0 |
| Abc family proteins mediated transport 8 53 0.0 1.0 |
| Interleukin 17 signaling 2 15 0.0 1.0 |
| Cytosolic iron sulfur cluster assembly 2 7 0.0 1.0 |
| Sumoylation of rna binding proteins 11 34 0.0 1.0 |
| Rhobtb gtpase cycle 14 30 0.0 1.0 |
| Activation of bad and translocation to mitochondria 7 8 0.0 1.0 |
| Sumoylation of sumoylation proteins 11 28 0.0 1.0 |
| Formation of tc ner pre incision complex 12 25 0.0 1.0 |
| Potential therapeutics for sars 3 38 0.0 1.0 |
| Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 9 10 0.0 1.0 |
| Regulation of localization of foxo transcription factors 5 6 0.0 1.0 |
| Apoptotic execution phase 2 29 0.0 1.0 |
| Hcmv late events 11 34 0.0 1.0 |
| Rna polymerase iii transcription initiation from type 1 promoter 9 10 0.0 1.0 |
| Ns1 mediated effects on host pathways 10 34 0.0 1.0 |
| Export of viral ribonucleoproteins from nucleus 11 29 0.0 1.0 |
| Innate immune system 61 278 0.0 1.0 |
| Nef mediated cd4 down regulation 3 6 0.0 1.0 |
| Postmitotic nuclear pore complex npc reformation 6 23 0.0 1.0 |
| Advanced glycosylation endproduct receptor signaling 0 7 0.0 1.0 |
| Protein ubiquitination 1 25 0.0 1.0 |
| Transcriptional regulation by ventx 7 16 0.0 1.0 |
| Clathrin mediated endocytosis 19 56 0.0 1.0 |
| Synthesis of pips at the plasma membrane 4 10 0.0 1.0 |
| Cell cell communication 15 28 0.0 1.0 |
| Rhou gtpase cycle 8 17 0.0 1.0 |
| Interferon alpha beta signaling 4 9 0.0 1.0 |
| Rhobtb1 gtpase cycle 9 20 0.0 1.0 |
| Rhov gtpase cycle 0 17 0.0 1.0 |
| Meiotic synapsis 1 13 0.0 1.0 |
| Rna polymerase iii transcription 10 11 0.0 1.0 |
| E2f mediated regulation of dna replication 1 11 0.0 1.0 |
| Rna polymerase iii transcription termination 5 6 0.0 1.0 |
| Disorders of transmembrane transporters 20 78 0.0 1.0 |
| Rho gtpases activate ktn1 3 8 0.0 1.0 |
| Tp53 regulates metabolic genes 5 34 0.0 1.0 |
| Sealing of the nuclear envelope ne by escrt iii 5 6 0.0 1.0 |
| Signaling by vegf 2 25 0.0 1.0 |
| Bile acid and bile salt metabolism 2 6 0.0 1.0 |
| Parasite infection 1 20 0.0 1.0 |
| Fcgr3a mediated il10 synthesis 0 7 0.0 1.0 |
| Synthesis of bile acids and bile salts 2 6 0.0 1.0 |
| Ub specific processing proteases 7 80 0.0 1.0 |
| Sensory processing of sound by outer hair cells of the cochlea 6 13 0.0 1.0 |
| Formation of incision complex in gg ner 3 17 0.0 1.0 |
| Trna modification in the nucleus and cytosol 1 19 0.0 1.0 |
| Signaling by braf and raf1 fusions 5 23 0.0 1.0 |
| Neuronal system 9 53 0.0 1.0 |
| Nef mediated cd8 down regulation 3 6 0.0 1.0 |
| Amino acids regulate mtorc1 4 12 0.0 1.0 |
| Cyclin d associated events in g1 11 12 0.0 1.0 |
| Cell cycle mitotic 57 251 0.0 1.0 |
| Nuclear import of rev protein 10 31 0.0 1.0 |
| Interactions of rev with host cellular proteins 10 34 0.0 1.0 |
| Flt3 signaling in disease 5 6 0.0 1.0 |
| M phase 45 190 0.0 1.0 |
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