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{"value": 1.3074541405089235e-06, "mean": 0.3510932752390905, "std": 0.3779284314527495, "bin": {"bin_50": 0.0046881619119119, "bin_100": 0.0004192854247962, "bin_250": 2.482842730275082e-12, "bin_500": 1.3773383160073333e-21}}, "signature_idxs": {"edge": [482, 241, 126, 125, 6, 245, 497, 501, 500, 498, 502, 143, 297, 493, 26, 394, 35, 397, 37, 398, 159, 277, 276, 319, 183, 184, 554, 69, 557, 312, 441, 202, 624, 86, 226, 98, 357, 250, 251, 108, 107, 105, 257, 345, 249, 114, 354], "full": [482, 2062, 2285, 1372, 345, 1981, 716, 241, 790, 1076, 719, 1008, 2491, 1467, 312, 105, 663, 723, 159, 1994, 864, 2295, 797, 1649, 202, 245, 1284, 609, 114, 125, 86, 493, 35, 1289, 69, 394, 2299, 729, 354, 1483, 554, 497, 249, 498, 617, 2152, 319, 1021, 276, 126, 734, 2435, 183, 500, 397, 2306, 501, 277, 250, 809, 357, 107, 108, 1832, 98, 502, 2855, 2498, 398, 26, 557, 37, 441, 184, 2437, 2705, 143, 872, 226, 873, 1203, 251, 624, 1109, 257, 973, 2038, 6, 297]}}, "Nonsense mediated decay nmd": 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202, 91, 86, 249, 226, 98, 617, 716, 357, 250, 251, 108, 107, 105, 530, 719, 114, 354, 734], "full": [2062, 2285, 1372, 1981, 716, 657, 2141, 241, 790, 1076, 719, 312, 105, 663, 723, 159, 794, 1994, 864, 797, 1742, 202, 245, 1284, 114, 125, 86, 493, 35, 1289, 69, 394, 2299, 729, 354, 554, 497, 249, 498, 617, 319, 1021, 276, 126, 734, 2435, 183, 500, 397, 2306, 501, 277, 250, 736, 809, 357, 107, 108, 1832, 98, 502, 2855, 2498, 398, 26, 557, 37, 441, 184, 1093, 2437, 2705, 143, 872, 226, 873, 1203, 91, 251, 2226, 2102, 1511, 417, 530, 297, 590]}}, "Signaling by robo receptors": {"direction": "up", "overlap": {"value": 89, "mean": 53.89563106796116, "std": 20.749810628210746, "bin": {"bin_50": 5, "bin_100": 11, "bin_250": 34, "bin_500": 61}}, "setsize": {"value": 137, "mean": 136.44174757281553, "std": 4.420166149665581, "bin": {"bin_50": 197, "bin_100": 197, "bin_250": 197, "bin_500": 197}}, "score": {"value": 4.682544283312828, "mean": -0.5803891128880495, "std": 1.9093246617268536, "bin": {"bin_50": 5.760416666666667, "bin_100": 6.585115379968587, "bin_250": 9.447341513292434, "bin_500": 9.79084407735697}}, "pval": {"value": 2.8333595183394067e-06, "mean": 0.4434346526843001, "std": 0.3809851422615608, "bin": {"bin_50": 0.0026787056516881, "bin_100": 3.349748569136237e-06, "bin_250": 9.723078599544061e-20, "bin_500": 4.332900143680664e-33}}, "signature_idxs": {"edge": [488, 474, 473, 11, 497, 14, 501, 500, 498, 502, 493, 26, 35, 37, 590, 549, 64, 554, 69, 557, 560, 77, 91, 86, 98, 617, 112, 108, 107, 106, 105, 601, 114, 611, 130, 126, 125, 143, 698, 657, 159, 663, 183, 184, 197, 774, 202, 201, 225, 226, 222, 716, 250, 251, 719, 249, 734, 241, 736, 243, 245, 729, 723, 822, 297, 817, 263, 273, 277, 275, 276, 328, 795, 321, 790, 319, 797, 809, 312, 357, 354, 417, 394, 397, 398, 441, 444, 530, 486], "full": [473, 1358, 474, 1797, 850, 197, 2055, 927, 263, 2278, 1980, 2062, 2285, 1372, 14, 1981, 716, 657, 1644, 2141, 241, 601, 1007, 790, 1076, 719, 486, 312, 105, 933, 1277, 1078, 488, 663, 723, 549, 201, 106, 243, 159, 1994, 77, 864, 795, 797, 1742, 202, 245, 1284, 114, 1907, 125, 86, 493, 35, 1289, 69, 394, 2299, 222, 729, 273, 11, 354, 275, 611, 554, 870, 225, 497, 249, 807, 498, 617, 319, 64, 1021, 276, 321, 1576, 126, 734, 2435, 183, 500, 397, 2306, 501, 277, 1830, 250, 736, 809, 357, 107, 108, 1832, 98, 502, 2855, 2498, 398, 26, 557, 37, 441, 184, 2437, 2705, 143, 872, 226, 1393, 873, 1203, 91, 560, 251, 2226, 444, 1027, 817, 1033, 130, 822, 1924, 328, 2836, 2180, 112, 975, 417, 530, 774, 698, 297, 590]}}, "Eukaryotic translation elongation": {"direction": "up", "overlap": {"value": 44, "mean": 40.33980582524272, "std": 13.865899638243102, "bin": {"bin_50": 3, "bin_100": 6, "bin_250": 21, "bin_500": 39}}, "setsize": {"value": 78, "mean": 76.70873786407768, "std": 1.3501604935966776, "bin": {"bin_50": 89, "bin_100": 89, "bin_250": 89, "bin_500": 89}}, "score": {"value": 4.660350933937813, "mean": -1.170264854227122, "std": 2.213815111182405, "bin": {"bin_50": 7.466600692726373, "bin_100": 7.700333247885157, "bin_250": 13.321217569997431, "bin_500": 16.35795652173913}}, "pval": {"value": 3.1567070766236327e-06, "mean": 0.3173586097479524, "std": 0.3781772268307828, "bin": {"bin_50": 0.0093752195011205, "bin_100": 0.0002305907491292, "bin_250": 1.931896399290418e-15, "bin_500": 5.120748959725622e-28}}, "signature_idxs": {"edge": [241, 126, 125, 245, 497, 501, 500, 498, 502, 143, 297, 390, 493, 26, 394, 35, 397, 37, 398, 159, 277, 276, 319, 547, 183, 184, 554, 69, 312, 441, 202, 86, 226, 98, 357, 250, 251, 108, 107, 105, 350, 249, 114, 354], "full": [2062, 2285, 1372, 1981, 716, 1273, 241, 790, 1076, 719, 312, 547, 105, 663, 350, 723, 390, 159, 1994, 864, 797, 202, 245, 1284, 114, 125, 86, 493, 35, 1289, 69, 394, 2299, 729, 354, 554, 497, 249, 498, 617, 319, 1021, 276, 126, 734, 2435, 183, 500, 397, 2306, 501, 277, 250, 809, 357, 107, 108, 1832, 98, 502, 2855, 2498, 398, 26, 557, 37, 441, 184, 2437, 2705, 143, 872, 226, 873, 1203, 1837, 251, 297]}}, "Response of eif2ak4 gcn2 to amino acid deficiency": {"direction": "up", "overlap": {"value": 44, "mean": 39.550970873786405, "std": 13.761485019110056, "bin": {"bin_50": 3, "bin_100": 6, "bin_250": 21, "bin_500": 40}}, "setsize": {"value": 77, "mean": 76.03155339805825, "std": 1.5173669435319213, "bin": {"bin_50": 94, "bin_100": 94, "bin_250": 94, "bin_500": 94}}, "score": {"value": 4.644717015879893, "mean": -1.127048342201767, "std": 2.220942857496925, "bin": {"bin_50": 7.052840776245032, "bin_100": 7.259187620889748, "bin_250": 12.402524376383322, "bin_500": 15.562010812555474}}, "pval": {"value": 3.405429137348648e-06, "mean": 0.3185079045659907, "std": 0.3803423215749384, "bin": {"bin_50": 0.010878638830109, "bin_100": 0.0003106175344779, "bin_250": 6.331346572660848e-15, "bin_500": 4.2122205807354805e-28}}, "signature_idxs": {"edge": [482, 241, 126, 125, 245, 497, 501, 500, 498, 502, 143, 297, 493, 26, 394, 35, 397, 37, 398, 159, 277, 276, 319, 183, 184, 554, 69, 312, 441, 202, 86, 226, 98, 357, 250, 251, 108, 107, 105, 257, 345, 249, 114, 354], "full": [482, 2062, 2285, 1372, 345, 1981, 716, 241, 790, 1076, 719, 1008, 312, 105, 663, 723, 159, 1994, 864, 797, 202, 245, 1284, 114, 125, 86, 493, 35, 1289, 69, 394, 2299, 729, 354, 554, 497, 249, 498, 617, 319, 1021, 276, 126, 734, 2435, 183, 500, 397, 2306, 501, 277, 250, 809, 357, 107, 108, 1832, 98, 502, 2855, 2498, 398, 26, 557, 37, 441, 184, 2437, 2705, 143, 872, 226, 873, 1203, 251, 257, 297]}}, "Srp dependent cotranslational protein targeting to membrane": {"direction": "up", "overlap": {"value": 46, "mean": 36.76699029126213, "std": 17.22196829379636, "bin": {"bin_50": 3, "bin_100": 6, "bin_250": 24, "bin_500": 41}}, "setsize": {"value": 91, "mean": 90.33495145631068, "std": 2.057296214960333, "bin": {"bin_50": 108, "bin_100": 108, "bin_250": 108, "bin_500": 108}}, "score": {"value": 4.449147599452447, "mean": -0.5167678337360311, "std": 1.7319679229133378, "bin": {"bin_50": 6.103951367781155, "bin_100": 6.254067584480601, "bin_250": 12.467762326169408, "bin_500": 12.866779638923289}}, "pval": {"value": 8.621175694223382e-06, "mean": 0.4521019696915908, "std": 0.3837080047653741, "bin": {"bin_50": 0.0157967173614079, "bin_100": 0.0006538796788392, "bin_250": 7.679881322617265e-17, "bin_500": 1.9961966511128148e-26}}, "signature_idxs": {"edge": [241, 126, 125, 245, 497, 501, 500, 498, 502, 143, 297, 493, 26, 394, 35, 397, 37, 398, 159, 277, 160, 276, 179, 319, 183, 184, 554, 555, 69, 312, 441, 202, 86, 226, 98, 357, 250, 251, 108, 107, 344, 105, 249, 114, 354, 239], "full": [344, 1002, 179, 2062, 2285, 1372, 1807, 1981, 716, 239, 241, 790, 1076, 719, 312, 105, 663, 723, 159, 1994, 864, 797, 160, 202, 245, 2543, 1284, 114, 2544, 125, 86, 493, 35, 1289, 69, 394, 2299, 729, 354, 2221, 2912, 554, 555, 806, 497, 249, 498, 617, 319, 2305, 1021, 276, 126, 734, 2435, 183, 500, 397, 2306, 501, 277, 250, 809, 357, 107, 108, 1832, 98, 502, 2855, 2498, 398, 26, 557, 37, 441, 184, 2437, 2705, 1298, 143, 872, 226, 873, 1203, 251, 2441, 2231, 1625, 297, 1061]}}, "Selenoamino acid metabolism": {"direction": "up", "overlap": {"value": 57, "mean": 45.359223300970875, "std": 16.116146621354947, "bin": {"bin_50": 3, "bin_100": 7, "bin_250": 22, "bin_500": 38}}, "setsize": {"value": 90, "mean": 88.94660194174757, "std": 1.9650003351851577, "bin": {"bin_50": 107, "bin_100": 107, "bin_250": 107, "bin_500": 107}}, "score": {"value": 4.407654083739957, "mean": -1.2269036973447986, "std": 2.2110932203759184, "bin": {"bin_50": 6.163256955810147, "bin_100": 7.523870967741935, "bin_250": 11.194117647058825, "bin_500": 11.501901977427773}}, "pval": {"value": 1.044962586904674e-05, "mean": 0.3270935993226454, "std": 0.3833177831487697, "bin": {"bin_50": 0.0154102901166228, "bin_100": 8.26937266766137e-05, "bin_250": 8.958713046433112e-15, "bin_500": 2.4448602444917682e-23}}, "signature_idxs": {"edge": [241, 126, 125, 245, 729, 723, 497, 501, 500, 820, 498, 502, 143, 297, 493, 26, 394, 35, 397, 37, 398, 159, 277, 815, 276, 790, 663, 319, 183, 184, 797, 554, 69, 809, 557, 312, 441, 202, 620, 86, 249, 82, 226, 98, 617, 716, 357, 250, 251, 354, 108, 107, 105, 719, 114, 610, 734], "full": [1969, 82, 1268, 2062, 2285, 1372, 1070, 1981, 716, 1812, 241, 790, 1076, 719, 312, 1558, 105, 663, 723, 159, 1994, 864, 797, 202, 245, 1284, 1475, 114, 125, 86, 493, 35, 1289, 69, 394, 1015, 2299, 729, 610, 354, 1197, 2222, 805, 554, 497, 249, 498, 617, 319, 1021, 276, 126, 734, 2435, 183, 500, 397, 2306, 501, 277, 250, 809, 357, 107, 108, 1832, 98, 502, 2855, 2498, 398, 26, 557, 37, 441, 184, 2437, 2705, 143, 872, 226, 873, 1203, 251, 815, 620, 820, 2924, 1146, 297]}}, "Mitotic g2 g2 m phases": {"direction": "up", "overlap": {"value": 48, "mean": 25.512135922330096, "std": 11.374146646790262, "bin": {"bin_50": 1, "bin_100": 2, "bin_250": 15, "bin_500": 28}}, "setsize": {"value": 83, "mean": 89.70388349514563, "std": 7.343161700072858, "bin": {"bin_50": 186, "bin_100": 186, "bin_250": 186, "bin_500": 186}}, "score": {"value": 4.375181362811546, "mean": 0.5564324413272281, "std": 1.2377579618165189, "bin": {"bin_50": 1.098841698841699, "bin_100": 1.0993788819875776, "bin_250": 3.648749533407988, "bin_500": 3.589077911258029}}, "pval": {"value": 1.2133155709692645e-05, "mean": 0.5721896286221594, "std": 0.3831596446417351, "bin": {"bin_50": 0.6025890703102443, "bin_100": 0.547752308120729, "bin_250": 5.153637214446024e-05, "bin_500": 9.496302423056428e-08}}, "signature_idxs": {"edge": [130, 488, 238, 243, 474, 473, 487, 11, 733, 283, 171, 698, 271, 263, 273, 157, 654, 275, 795, 56, 321, 549, 794, 807, 811, 560, 743, 197, 774, 201, 440, 622, 373, 510, 763, 222, 522, 223, 112, 714, 710, 106, 601, 248, 598, 486, 237, 611], "full": [473, 1358, 474, 850, 1256, 1359, 197, 263, 710, 157, 1977, 714, 2768, 598, 654, 237, 238, 857, 601, 1007, 486, 487, 933, 1277, 1078, 488, 549, 201, 106, 243, 794, 1648, 795, 271, 1907, 222, 273, 11, 223, 275, 1195, 611, 870, 948, 248, 807, 1750, 733, 321, 1576, 440, 1830, 1093, 811, 1022, 560, 2310, 1027, 1396, 1398, 1304, 510, 743, 283, 622, 1033, 130, 1209, 56, 2180, 522, 112, 975, 763, 1338, 900, 373, 171, 1705, 774, 2824, 698, 1544]}}, "Cilium assembly": {"direction": "up", "overlap": {"value": 30, "mean": 17.691747572815533, "std": 8.208427462797529, "bin": {"bin_50": 1, "bin_100": 2, "bin_250": 9, "bin_500": 16}}, "setsize": {"value": 50, "mean": 60.07281553398058, "std": 7.176657065505861, "bin": {"bin_50": 183, "bin_100": 183, "bin_250": 183, "bin_500": 183}}, "score": {"value": 4.101932040795207, "mean": 0.7163847705434252, "std": 1.1196611241046792, "bin": {"bin_50": 1.1172908723929131, "bin_100": 1.1179388882624872, "bin_250": 2.0972957504650163, "bin_500": 1.8903807292247805}}, "pval": {"value": 4.09714622087165e-05, "mean": 0.5030560453085753, "std": 0.3669144822823486, "bin": {"bin_50": 0.5965750836212735, "bin_100": 0.5389205405950839, "bin_250": 0.0362613229238399, "bin_500": 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[473, 1358, 474, 850, 197, 263, 1007, 486, 933, 1277, 1078, 488, 549, 201, 106, 243, 795, 1907, 222, 273, 11, 275, 611, 870, 807, 321, 1576, 1830, 560, 1027, 1033, 130, 2180, 112, 975, 774, 698]}}, "Degradation of axin": {"direction": "up", "overlap": {"value": 28, "mean": 11.135922330097088, "std": 6.515923056292238, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 8, "bin_500": 16}}, "setsize": {"value": 37, "mean": 36.5, "std": 1.1005294401076644, "bin": {"bin_50": 48, "bin_100": 48, "bin_250": 48, "bin_500": 48}}, "score": {"value": 3.5823558435547413, "mean": 0.6371703324335989, "std": 1.2875505119575097, "bin": {"bin_50": 4.385149804602692, "bin_100": 2.1596819256393727, "bin_250": 8.186776859504132, "bin_500": 10.005175983436851}}, "pval": {"value": 0.000340509527666, "mean": 0.5044883973483546, "std": 0.3689236351245595, "bin": {"bin_50": 0.2106238865633207, "bin_100": 0.3776146865857887, "bin_250": 1.886212722215113e-05, "bin_500": 4.501330204995498e-10}}, "signature_idxs": {"edge": [130, 488, 850, 243, 474, 473, 11, 870, 698, 263, 273, 275, 795, 321, 549, 975, 933, 807, 560, 774, 197, 201, 222, 1033, 112, 106, 486, 611], "full": [473, 1358, 474, 850, 197, 263, 1007, 486, 933, 1277, 1078, 488, 549, 201, 106, 243, 795, 1907, 222, 273, 11, 275, 611, 870, 807, 321, 1576, 1830, 560, 1027, 1033, 130, 2180, 112, 975, 774, 698]}}, "Regulation of runx3 expression and activity": {"direction": "up", "overlap": {"value": 26, "mean": 11.46359223300971, "std": 6.642474003130895, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 8, "bin_500": 16}}, "setsize": {"value": 36, "mean": 36.730582524271846, "std": 1.4202887203012589, "bin": {"bin_50": 52, "bin_100": 52, "bin_250": 52, "bin_500": 52}}, "score": {"value": 3.564633473376776, "mean": 0.6696914114866416, "std": 1.288769965462232, "bin": {"bin_50": 4.039615846338536, "bin_100": 1.989502871855813, "bin_250": 7.439519158527423, "bin_500": 8.889809063722106}}, "pval": {"value": 0.0003643649991882, "mean": 0.4949350431730664, "std": 0.3632605735082652, "bin": {"bin_50": 0.2260688267312995, "bin_100": 0.4017902994798545, "bin_250": 3.456376130332665e-05, "bin_500": 1.7241956968386135e-09}}, "signature_idxs": {"edge": [130, 488, 850, 243, 474, 473, 11, 870, 698, 263, 273, 275, 795, 321, 549, 975, 807, 560, 774, 197, 201, 222, 112, 106, 486, 611], "full": [473, 1358, 474, 850, 197, 263, 1007, 486, 933, 1277, 1078, 488, 549, 201, 106, 243, 795, 1907, 222, 273, 11, 275, 611, 870, 807, 321, 1576, 1830, 560, 1027, 130, 2180, 112, 975, 774, 698]}}, "Recruitment of mitotic centrosome proteins and complexes": {"direction": "up", "overlap": {"value": 18, "mean": 10.75485436893204, "std": 4.776113780352103, "bin": {"bin_50": 0, "bin_100": 1, "bin_250": 4, "bin_500": 8}}, "setsize": {"value": 25, "mean": 32.21116504854369, "std": 4.3238525164960775, "bin": {"bin_50": 82, "bin_100": 82, "bin_250": 82, "bin_500": 82}}, "score": {"value": 3.5496740302001744, "mean": 0.6690475765725821, "std": 1.0085704741220791, "bin": {"bin_50": 0.0, "bin_100": 1.248908841501434, "bin_250": 2.0571190327287887, "bin_500": 2.11878681125117}}, "pval": {"value": 0.0003857084283973, "mean": 0.4763419930316802, "std": 0.3559421309914655, "bin": {"bin_50": 1.0, "bin_100": 0.5557866832475982, "bin_250": 0.1417970181156078, "bin_500": 0.0467519249513273}}, "signature_idxs": {"edge": [763, 522, 598, 157, 743, 654, 714, 710, 56, 237, 440, 601, 622, 283, 248, 271, 373, 794], "full": [710, 157, 714, 598, 654, 237, 601, 794, 271, 1195, 248, 1750, 440, 811, 1396, 1398, 743, 283, 622, 1209, 56, 522, 763, 373, 1705]}}, "Tcr signaling": {"direction": "up", "overlap": {"value": 32, "mean": 14.79368932038835, "std": 8.50292119881085, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 8, "bin_500": 18}}, "setsize": {"value": 46, "mean": 47.728155339805824, "std": 3.2417009042427978, "bin": {"bin_50": 85, "bin_100": 85, "bin_250": 85, "bin_500": 85}}, "score": {"value": 3.528991696230747, "mean": 0.3776708616120087, "std": 1.3249802424411328, "bin": {"bin_50": 2.444606413994169, "bin_100": 1.203944203944204, "bin_250": 4.236986154341526, "bin_500": 5.3787197070779165}}, "pval": {"value": 0.0004171462194615, "mean": 0.5474588628929388, "std": 0.3685330173213761, "bin": {"bin_50": 0.3426841548479852, "bin_100": 0.5688343041108967, "bin_250": 0.001103107189202, "bin_500": 1.0885978827747786e-07}}, "signature_idxs": {"edge": [130, 488, 850, 243, 474, 473, 11, 870, 1022, 698, 263, 273, 275, 328, 795, 321, 549, 975, 933, 807, 560, 774, 197, 444, 201, 222, 1033, 112, 1027, 106, 486, 611], "full": [473, 1358, 474, 850, 2271, 197, 263, 1007, 2067, 486, 933, 1277, 1078, 488, 549, 201, 106, 243, 795, 1561, 1907, 222, 273, 11, 275, 611, 870, 807, 321, 1576, 1830, 1022, 2003, 560, 444, 1027, 1304, 1033, 130, 1924, 328, 2180, 112, 975, 774, 698]}}, "Degradation of beta catenin by the destruction complex": {"direction": "up", "overlap": {"value": 33, "mean": 14.8252427184466, "std": 8.029589918636947, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 8, "bin_500": 17}}, "setsize": {"value": 49, "mean": 48.63834951456311, "std": 2.025992551710678, "bin": {"bin_50": 77, "bin_100": 77, "bin_250": 77, "bin_500": 77}}, "score": {"value": 3.5209281607828147, "mean": 0.4830095996380346, "std": 1.2813542829769398, "bin": {"bin_50": 2.704081632653061, "bin_100": 1.331738437001595, "bin_250": 4.732063720206012, "bin_500": 5.664903181189488}}, "pval": {"value": 0.0004300391060525, "mean": 0.5534777326316677, "std": 0.3757731368449524, "bin": {"bin_50": 0.3161039234082394, "bin_100": 0.5331665625078387, "bin_250": 0.000570524605763, "bin_500": 1.2923579759637288e-07}}, "signature_idxs": {"edge": [130, 488, 850, 243, 474, 473, 11, 870, 1022, 282, 698, 958, 263, 273, 275, 795, 321, 549, 975, 933, 794, 807, 560, 774, 197, 201, 222, 1033, 112, 1027, 106, 486, 611], "full": [473, 1358, 474, 850, 197, 263, 1007, 486, 2542, 933, 1277, 1078, 488, 549, 201, 106, 243, 794, 1648, 1905, 795, 1907, 222, 1188, 273, 11, 1747, 275, 611, 1573, 870, 807, 321, 1576, 1830, 1022, 560, 1027, 282, 1095, 1304, 958, 1033, 130, 2180, 112, 975, 774, 698]}}, "S phase": {"direction": "up", "overlap": {"value": 52, "mean": 25.58252427184466, "std": 12.311904628033766, "bin": {"bin_50": 3, "bin_100": 3, "bin_250": 14, "bin_500": 29}}, "setsize": {"value": 94, "mean": 94.497572815534, "std": 6.6662819095148595, "bin": {"bin_50": 158, "bin_100": 158, "bin_250": 158, "bin_500": 158}}, "score": {"value": 3.513021042177254, "mean": 0.3936025929765626, "std": 1.1799446716032989, "bin": {"bin_50": 4.114344543582704, "bin_100": 1.9835716661124043, "bin_250": 4.038017890772128, "bin_500": 4.576480290285337}}, "pval": {"value": 0.0004430423883903, "mean": 0.6471527110395977, "std": 0.3778079902664983, "bin": {"bin_50": 0.0421277892223037, "bin_100": 0.2022112376683019, "bin_250": 3.2630298728536805e-05, "bin_500": 5.188292183519667e-10}}, "signature_idxs": {"edge": [130, 488, 243, 850, 124, 474, 473, 487, 11, 151, 881, 17, 819, 870, 140, 698, 965, 395, 569, 263, 273, 957, 392, 275, 813, 42, 795, 321, 549, 667, 975, 933, 932, 548, 446, 807, 431, 432, 560, 435, 197, 774, 201, 222, 641, 223, 112, 106, 594, 863, 486, 611], "full": [473, 1358, 474, 850, 197, 1454, 594, 263, 1984, 140, 930, 1007, 2066, 486, 487, 932, 933, 1277, 1078, 488, 548, 549, 201, 106, 243, 1181, 1472, 1993, 124, 863, 392, 42, 1741, 1906, 431, 795, 432, 1474, 1560, 1907, 222, 1086, 435, 1384, 273, 11, 667, 1747, 223, 1292, 275, 611, 395, 870, 807, 321, 1576, 1830, 1022, 560, 813, 2310, 1027, 446, 1304, 957, 819, 1033, 130, 569, 881, 965, 1414, 2180, 2890, 112, 975, 2023, 17, 1132, 1341, 2865, 1436, 1441, 2719, 1706, 2263, 1877, 774, 698, 151, 641, 1791, 2917]}}, "Asymmetric localization of pcp proteins": {"direction": "up", "overlap": {"value": 28, "mean": 11.28883495145631, "std": 6.482730726459962, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 8, "bin_500": 16}}, "setsize": {"value": 38, "mean": 37.80825242718446, "std": 1.1863421199640956, "bin": {"bin_50": 54, "bin_100": 54, "bin_250": 54, "bin_500": 54}}, "score": {"value": 3.5044816863788983, "mean": 0.5764639774033125, "std": 1.2423982841678427, "bin": {"bin_50": 3.8864073931459377, "bin_100": 1.9140461215932916, "bin_250": 7.1146245059288535, "bin_500": 8.42018088700011}}, "pval": {"value": 0.0004574970331159, "mean": 0.5188050170985335, "std": 0.3682278814782295, "bin": {"bin_50": 0.2336798458054532, "bin_100": 0.4135270958140081, "bin_250": 4.580951341181433e-05, "bin_500": 3.204187515072865e-09}}, "signature_idxs": {"edge": [130, 488, 850, 243, 474, 473, 11, 870, 698, 263, 273, 275, 795, 321, 549, 975, 933, 807, 560, 774, 197, 201, 222, 1033, 112, 106, 486, 611], "full": [473, 1358, 474, 850, 197, 263, 1007, 486, 933, 1277, 1078, 488, 549, 201, 106, 243, 795, 1907, 222, 273, 11, 275, 611, 870, 807, 321, 1576, 1830, 560, 1027, 2084, 1033, 130, 2180, 112, 975, 774, 698]}}, "Regulation of pten stability and activity": {"direction": "up", "overlap": {"value": 31, "mean": 12.611650485436892, "std": 7.056269001912706, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 9, "bin_500": 17}}, "setsize": {"value": 42, "mean": 41.82281553398058, "std": 2.1755846965350556, "bin": {"bin_50": 63, "bin_100": 63, "bin_250": 63, "bin_500": 63}}, "score": {"value": 3.4820694808277755, "mean": 0.6486618107800725, "std": 1.2659780846667748, "bin": {"bin_50": 3.3192890059249507, "bin_100": 1.634734441186054, "bin_250": 6.840940525587828, "bin_500": 7.399738408803897}}, "pval": {"value": 0.0004975545735377, "mean": 0.5229501310802542, "std": 0.3745012259374719, "bin": {"bin_50": 0.2670314735990955, "bin_100": 0.4635835476922714, "bin_250": 2.0666171992443645e-05, "bin_500": 5.051369526150515e-09}}, "signature_idxs": {"edge": [130, 242, 488, 850, 243, 474, 473, 11, 1023, 870, 698, 263, 273, 275, 795, 321, 549, 975, 933, 807, 560, 774, 197, 201, 222, 1033, 112, 1027, 106, 486, 611], "full": [473, 1358, 474, 850, 197, 263, 2361, 1007, 242, 486, 933, 1277, 1078, 488, 549, 201, 106, 243, 1993, 795, 1907, 222, 273, 11, 275, 611, 870, 807, 321, 1576, 1830, 1023, 560, 1027, 1033, 130, 2180, 112, 975, 774, 1151, 698]}}, "Mitotic g1 phase and g1 s transition": {"direction": "up", "overlap": {"value": 47, "mean": 22.104368932038835, "std": 11.678595487596883, "bin": {"bin_50": 2, "bin_100": 2, "bin_250": 12, "bin_500": 26}}, "setsize": {"value": 75, "mean": 76.02184466019418, "std": 5.354610434747646, "bin": {"bin_50": 143, "bin_100": 143, "bin_250": 143, "bin_500": 143}}, "score": {"value": 3.46304609193967, "mean": 0.5927262006732629, "std": 1.3736272695770486, "bin": {"bin_50": 2.956560283687943, "bin_100": 1.4408742220292372, "bin_250": 3.7776637372506254, "bin_500": 4.50082217524078}}, "pval": {"value": 0.0005340968954885, "mean": 0.5705780900762646, "std": 0.3846948779804449, "bin": {"bin_50": 0.1552273103013288, "bin_100": 0.4106784084854392, "bin_250": 0.0002005801300952, "bin_500": 5.104417491457732e-09}}, "signature_idxs": {"edge": [130, 488, 850, 243, 124, 474, 473, 487, 11, 870, 140, 698, 395, 263, 957, 392, 273, 275, 813, 795, 42, 321, 549, 786, 975, 667, 933, 932, 794, 548, 446, 807, 560, 435, 774, 197, 201, 222, 359, 223, 112, 106, 863, 598, 486, 857, 611], "full": [473, 1358, 474, 850, 197, 1454, 263, 1371, 786, 1269, 598, 1984, 2140, 140, 930, 857, 1007, 486, 487, 932, 933, 1277, 1078, 488, 548, 549, 201, 106, 243, 794, 1648, 1380, 1993, 124, 863, 392, 42, 795, 1907, 222, 435, 1384, 273, 11, 667, 223, 275, 611, 395, 870, 807, 321, 1576, 1830, 1093, 1022, 359, 560, 813, 2310, 1027, 446, 1095, 1304, 957, 130, 2180, 112, 975, 2023, 2865, 1441, 774, 698, 2917]}}, "Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s": {"direction": "up", "overlap": {"value": 29, "mean": 21.27912621359223, "std": 8.810973476604579, "bin": {"bin_50": 0, "bin_100": 4, "bin_250": 12, "bin_500": 22}}, "setsize": {"value": 51, "mean": 50.43446601941748, "std": 1.4474874301684992, "bin": {"bin_50": 59, "bin_100": 59, "bin_250": 59, "bin_500": 59}}, "score": {"value": 3.442672760966771, "mean": -0.6423341772855271, "std": 1.4039245476891489, "bin": {"bin_50": 0.0, "bin_100": 7.606818181818181, "bin_250": 10.61934561058466, "bin_500": 12.041475437701854}}, "pval": {"value": 0.0005759958319053, "mean": 0.4501870221883518, "std": 0.3707470696386276, "bin": {"bin_50": 1.0, "bin_100": 0.0026232179628348, "bin_250": 1.4616144482065361e-08, "bin_500": 1.5625488955315936e-14}}, "signature_idxs": {"edge": [482, 241, 405, 126, 478, 497, 501, 500, 145, 502, 394, 657, 397, 645, 277, 276, 51, 183, 554, 69, 312, 202, 91, 98, 111, 107, 105, 614, 483], "full": [645, 1063, 478, 649, 51, 482, 483, 1981, 716, 657, 241, 1008, 312, 2069, 105, 202, 1289, 69, 394, 804, 2635, 614, 1018, 554, 497, 276, 126, 734, 2435, 183, 500, 397, 2306, 501, 277, 809, 107, 1832, 98, 502, 2855, 2498, 2705, 91, 2158, 111, 1096, 405, 145, 1354, 1153]}}, "Fceri mediated nf kb activation": {"direction": "up", "overlap": {"value": 30, "mean": 13.599514563106796, "std": 7.591659945968655, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 8, "bin_500": 16}}, "setsize": {"value": 41, "mean": 43.58252427184466, "std": 2.4879291964009105, "bin": {"bin_50": 68, "bin_100": 68, "bin_250": 68, "bin_500": 68}}, "score": {"value": 3.4375259718910187, "mean": 0.43538002101356, "std": 1.318650463428372, "bin": {"bin_50": 3.070057873895827, "bin_100": 1.5119855269109, "bin_250": 5.446831955922865, "bin_500": 6.144290492116579}}, "pval": {"value": 0.0005870544174508, "mean": 0.532490131621357, "std": 0.3690692407606546, "bin": {"bin_50": 0.2849410889163232, "bin_100": 0.4895400608205746, "bin_250": 0.0002422075599845, "bin_500": 1.1806063176514389e-07}}, "signature_idxs": {"edge": [130, 488, 850, 243, 474, 473, 11, 870, 1022, 698, 263, 273, 275, 795, 321, 549, 975, 933, 807, 560, 774, 197, 201, 222, 1033, 112, 1027, 106, 486, 611], "full": [473, 1358, 474, 850, 2271, 197, 263, 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"Er to golgi anterograde transport": {"direction": "up", "overlap": {"value": 31, "mean": 19.152912621359224, "std": 7.637631429097237, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 13, "bin_500": 22}}, "setsize": {"value": 68, "mean": 74.15776699029126, "std": 6.107600140782552, "bin": {"bin_50": 129, "bin_100": 129, "bin_250": 129, "bin_500": 129}}, "score": {"value": 3.345550237773909, "mean": 0.4357486981835305, "std": 0.9360192475456132, "bin": {"bin_50": 1.5972576530612246, "bin_100": 2.447226313205695, "bin_250": 4.648261312381784, "bin_500": 4.133701679108133}}, "pval": {"value": 0.0008211948129457, "mean": 0.6456866134420882, "std": 0.3613336360589621, "bin": {"bin_50": 0.4717478376334574, "bin_100": 0.1330503697063572, "bin_250": 1.5944428933097853e-05, "bin_500": 2.5400293181433384e-07}}, "signature_idxs": {"edge": [1, 476, 699, 496, 382, 300, 283, 169, 700, 164, 155, 162, 326, 190, 54, 180, 754, 425, 556, 210, 433, 316, 204, 622, 90, 510, 219, 618, 714, 597, 248], "full": 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"std": 0.9638132242129624, "bin": {"bin_50": 1.3881715951686795, "bin_100": 2.122502666192677, "bin_250": 3.986341615877481, "bin_500": 3.5034108681907425}}, "pval": {"value": 0.0018030744177681, "mean": 0.6299790557050085, "std": 0.3700222187340509, "bin": {"bin_50": 0.5194717620066895, "bin_100": 0.1774035227613552, "bin_250": 6.839179017988141e-05, "bin_500": 2.8283774344130704e-06}}, "signature_idxs": {"edge": [1, 476, 699, 496, 382, 300, 283, 169, 700, 164, 155, 162, 326, 190, 54, 180, 754, 425, 556, 210, 433, 316, 204, 622, 90, 510, 219, 618, 714, 597, 248], "full": [476, 780, 155, 1452, 924, 382, 425, 1973, 710, 928, 597, 2847, 714, 180, 219, 1182, 1744, 2366, 1187, 433, 316, 162, 1294, 1569, 943, 164, 1570, 496, 1483, 248, 556, 54, 811, 90, 204, 2878, 618, 2749, 2773, 1396, 1398, 326, 510, 283, 622, 2672, 1, 1101, 1587, 960, 2006, 754, 169, 190, 1329, 1120, 2520, 1338, 900, 210, 2466, 1145, 1534, 1149, 913, 1446, 699, 300, 700, 919]}}, "Scavenging by class b receptors": {"direction": "dw", "overlap": {"value": 1, "mean": 0.145679012345679, "std": 0.366514912271715, "bin": {}}, "setsize": {"value": 1, "mean": 1.0419753086419754, "std": 0.2005327457209575, "bin": {}}, "score": {"value": -3.118802488078969, "mean": 2.082821567211886, "std": 1.8633299667806096, "bin": {}}, "pval": {"value": 0.0018158764259745, "mean": 0.0465602836219474, "std": 0.1224919585458108, "bin": {}}, "signature_idxs": {"edge": [2852], "full": [2852]}}, "Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1": {"direction": "up", "overlap": {"value": 22, "mean": 14.026699029126211, "std": 7.183906351200202, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 8, "bin_500": 18}}, "setsize": {"value": 49, "mean": 48.65533980582524, "std": 2.917580729254371, "bin": {"bin_50": 68, "bin_100": 68, "bin_250": 68, "bin_500": 68}}, "score": {"value": 3.111800506462467, "mean": 0.5636343266746052, "std": 1.1799230201059223, "bin": {"bin_50": 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1.96894420790723e-09}}, "signature_idxs": {"edge": [130, 488, 243, 850, 124, 474, 473, 487, 11, 17, 870, 698, 395, 569, 263, 273, 957, 392, 275, 813, 42, 795, 321, 549, 667, 975, 933, 932, 548, 446, 807, 431, 432, 560, 435, 197, 774, 201, 222, 641, 112, 106, 707, 863, 486, 611], "full": [473, 1358, 474, 850, 197, 1454, 707, 263, 1984, 930, 2215, 1007, 2066, 486, 487, 932, 933, 1277, 1078, 488, 548, 549, 201, 106, 243, 1181, 1472, 124, 863, 392, 42, 1741, 1906, 431, 795, 432, 1474, 1560, 1907, 222, 1086, 435, 1384, 273, 11, 667, 1292, 275, 1654, 611, 395, 870, 807, 321, 1576, 1830, 2550, 1022, 560, 813, 1027, 446, 1304, 957, 1583, 1033, 130, 569, 2180, 2890, 112, 975, 2023, 17, 1132, 1341, 2865, 1441, 2719, 1706, 2263, 1877, 774, 698, 641, 1791, 2917]}}, "Er quality control compartment erqc": {"direction": "up", "overlap": {"value": 0, "mean": 1.0606796116504855, "std": 0.95210932118493, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 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2, "mean": 3.4174757281553396, "std": 2.235087678151022, "bin": {}}, "setsize": {"value": 12, "mean": 12.29126213592233, "std": 1.9577134867833192, "bin": {}}, "score": {"value": -1.9649688764153672, "mean": 0.3504356398232429, "std": 0.8232177003646645, "bin": {}}, "pval": {"value": 0.0494178399173284, "mean": 0.5841793314671695, "std": 0.3100303898066223, "bin": {}}, "signature_idxs": {"edge": [2848, 2928], "full": [1162, 2135, 2209, 2928, 2848, 1471, 1382, 2004, 740, 954, 566, 1207]}}, "Translesion synthesis by polh": {"direction": "up", "overlap": {"value": 3, "mean": 4.825242718446602, "std": 3.2558451826997414, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 2}}, "setsize": {"value": 11, "mean": 12.28883495145631, "std": 0.862695933530379, "bin": {"bin_50": 20, "bin_100": 20, "bin_250": 20, "bin_500": 20}}, "score": {"value": 1.962487388110367, "mean": -0.2513791687876471, "std": 0.8859670011372885, "bin": {"bin_50": 10.877551020408164, "bin_100": 5.35725677830941, 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