{"signature": {"size": 3193, "values": [["O60830", 4.042548479567164], ["Q9BS16", 3.8069179773746313], ["P24390", 3.7462657069794476], ["Q99595", 3.6753208773984025], ["P23786", 3.6003046943759847], ["Q567V2", 3.5925647235517952], ["Q9BQE5", 3.5925647235517952], ["P21796", 3.5491802513502524], ["Q69YU5", 3.5371028334084], ["A6NIH7", 3.4750650461264545], ["P43307", 3.4750650461264545], ["P16278", 3.418959561273887], ["P14406", 3.4056877380284694], ["Q9C0H2", 3.351325980333631], ["Q14108", 3.309160878702859], ["P45880", 3.285196134499565], ["Q9NS69", 3.2657379732892013], ["P09601", 3.250973747172662], ["P42785", 3.226034750624375], ["P50897", 3.2108682288698214], ["O60637", 3.205778316696798], ["Q8NBX0", 3.148622465340775], ["Q9UDW1", 3.143317850644801], ["O75153", 3.1219129348274657], ["P80303", 3.1219129348274657], ["Q13432", 3.105660523374089], ["Q99720", 3.0892345539041384], ["Q8N0U8", 3.083720150229578], ["O00461", 3.078186020550252], ["Q15363", 3.078186020550252], ["Q9Y3B3", 3.067058131253242], ["O75964", 3.0502155042807657], ["Q5BJF2", 3.0502155042807657], ["P43490", 3.01019588582792], ["O43676", 2.9927281115085713], ["Q15800", 2.975065555239934], ["O43731", 2.96913415144942], ["Q9UHX1", 2.9330756917337433], ["Q9H3G5", 2.926986348323763], ["O60443", 2.9208738951110123], ["Q5R3I4", 2.9208738951110123], ["Q8N4H5", 2.8899600348937455], ["Q9HB40", 2.8899600348937455], ["Q8WTV0", 2.871125247428219], ["Q9Y2R0", 2.8520707218101506], ["O00165", 2.832792341598909], ["O43169", 2.832792341598909], ["Q9H2D1", 2.813285883739657], ["Q15070", 2.800152733484291], ["Q8N511", 2.7869149799952893], ["Q70HW3", 2.760120300435202], ["Q13505", 2.746560633651398], ["O60502", 2.7397396070190534], ["O43657", 2.732890881137026], ["Q9UBX3", 2.732890881137026], ["Q02818", 2.69120665946763], ["Q8NBJ7", 2.69120665946763], ["Q9H061", 2.6699756767430465], ["P30536", 2.6556741514333573], ["Q9UHG3", 2.6556741514333573], ["Q03164", 2.648478537565285], ["Q9NR77", 2.6412527563805264], ["P46379", 2.6339966056994], ["Q15392", 2.6339966056994], ["Q15629", 2.62670988147732], ["P49721", 2.6193923777828645], ["Q9Y248", 2.6193923777828645], ["Q8NE00", 2.6120438867755347], ["Q5VW38", 2.5972531017791676], ["P30519", 2.589810382359061], ["Q9UDX5", 2.589810382359061], ["Q9Y487", 2.582335824717171], ["P07602", 2.5672903217950718], ["Q13126", 2.5597189348802236], ["Q14849", 2.536807538431712], ["Q96ES6", 2.5291039002629425], ["O15173", 2.5057902110255577], ["Q8IXH7", 2.5057902110255577], ["Q8NB78", 2.5057902110255577], ["Q8NHP8", 2.4979505993683864], ["Q8NCC3", 2.474223234824225], ["O75844", 2.4501778760429596], ["Q8NCH0", 2.4420909128633217], ["Q96A26", 2.4420909128633217], ["Q9UQB8", 2.4420909128633217], ["Q9Y282", 2.4339675988258307], ["O95197", 2.4176108705977826], ["Q9HD20", 2.4176108705977826], ["Q9Y680", 2.401105570157818], ["Q8NC54", 2.384449533896188], ["Q9HD45", 2.376064301841973], ["P42892", 2.359178009634381], ["Q86UE4", 2.359178009634381], ["Q7Z4Q2", 2.3421353798449456], ["P11117", 2.3335547149498175], ["Q9BTX1", 2.3335547149498175], ["Q9H6V9", 2.324934091671502], ["Q9H773", 2.324934091671502], ["Q9H1E5", 2.3162732124688055], ["Q06136", 2.3075717767503545], ["Q9P2W9", 2.3075717767503545], ["Q8TB61", 2.2988294808347165], ["P10253", 2.2900460179099036], ["O60499", 2.2812210779922095], ["O75503", 2.2812210779922095], ["Q8TAD4", 2.2812210779922095], ["Q9NQX7", 2.263445511133267], ["Q9NPH0", 2.254494247986381], ["Q7L0J3", 2.245500235348313], ["Q9NRY5", 2.245500235348313], ["O14949", 2.2364631467360248], ["Q03518", 2.2364631467360248], ["Q86XL3", 2.2364631467360248], ["Q9NQC3", 2.2364631467360248], ["Q8WY22", 2.2182584184461103], ["Q9UKR5", 2.2182584184461103], ["Q13510", 2.1998773817605315], ["Q8IXU6", 2.1906198942531567], ["O95684", 2.1813172981447764], ["P29083", 2.171969241928602], ["Q9BXJ9", 2.1625753703264308], ["O95628", 2.153135324237049], ["P04062", 2.153135324237049], ["Q8N2A8", 2.1436487406837603], ["O94915", 2.1052296336435044], ["O43760", 2.09550477869399], ["Q96CU9", 2.09550477869399], ["P10619", 2.0857311239846426], ["Q8NE01", 2.075908277865556], ["P08183", 2.0361169935164405], ["P51648", 2.015915696016737], ["Q7LGA3", 1.985222235335816], ["Q3SXM5", 1.9748849511122126], ["Q9NX00", 1.9748849511122126], ["Q9NZ45", 1.9748849511122126], ["Q13576", 1.9435485068003742], ["P13073", 1.9329933181047383], ["P27105", 1.9329933181047383], ["Q93050", 1.9329933181047383], ["Q9Y6J9", 1.9329933181047383], ["O60725", 1.9223825076951602], ["P51572", 1.9223825076951602], ["Q6P4A7", 1.9117156067218775], ["Q96A57", 1.9117156067218775], ["Q9Y6C9", 1.9117156067218775], ["P78417", 1.9009921408923331], ["Q9HC07", 1.9009921408923331], ["Q14739", 1.8684775279957868], ["Q96KC8", 1.8575229481079278], ["Q9UQ84", 1.8575229481079278], ["Q7KZN9", 1.8465093473865353], ["Q9Y6M7", 1.8465093473865353], ["Q15057", 1.8354362171377097], ["Q9BRR6", 1.8354362171377097], ["Q9UBV2", 1.8354362171377097], ["O95202", 1.8243030426289284], ["O95433", 1.8243030426289284], ["Q14997", 1.8243030426289284], ["Q16850", 1.8243030426289284], ["Q96G23", 1.8243030426289284], ["O96005", 1.8131093029975978], ["Q13423", 1.801854471157927], ["O43772", 1.7905380137060627], ["O94919", 1.7905380137060627], ["Q969T7", 1.7905380137060627], ["Q9BUN8", 1.7905380137060627], ["P54802", 1.7791593908234755], ["Q9BRK5", 1.7791593908234755], ["Q9NW15", 1.7791593908234755], ["P53985", 1.7677180561785404], ["O75027", 1.744645033106282], ["O95470", 1.744645033106282], ["P67812", 1.7330122185385242], ["Q8IZA0", 1.7330122185385242], ["Q9H2V7", 1.7330122185385242], ["Q9NUQ9", 1.7330122185385242], ["Q15165", 1.7213144397174807], ["Q86YN1", 1.7095511162040427], ["Q5VUD6", 1.6977216604154457], ["Q8WUJ1", 1.6977216604154457], ["Q9Y4G8", 1.6977216604154457], ["P24539", 1.6858254775131012], ["Q8N2H4", 1.6858254775131012], ["Q9Y5M8", 1.6858254775131012], ["P51798", 1.6738619652882785], ["Q16740", 1.6738619652882785], ["Q4VCS5", 1.6738619652882785], ["Q96EK5", 1.6738619652882785], ["Q9BUR4", 1.6738619652882785], ["Q6UW02", 1.661830514045592], ["Q96KA5", 1.661830514045592], ["Q9NZJ7", 1.6497305064842487], ["O60784", 1.6375613175769943], ["O75381", 1.6375613175769943], ["O95831", 1.6375613175769943], ["Q96DY7", 1.6375613175769943], ["Q8N128", 1.6253223144467295], ["Q9H6D7", 1.6253223144467295], ["P55010", 1.6130128562407051], ["Q9BV10", 1.6130128562407051], ["Q9H4I3", 1.6130128562407051], ["Q9P0J0", 1.6006322940022837], ["Q08380", 1.575655220295083], ["Q8N2K0", 1.575655220295083], ["P13473", 1.5630573692038123], ["O75306", 1.5503857345605445], ["P46977", 1.5503857345605445], ["Q8WVC6", 1.5503857345605445], ["Q9HCL2", 1.5503857345605445], ["Q9UBS8", 1.5503857345605445], ["Q9UJX3", 1.5503857345605445], ["O14925", 1.5376396248754793], ["Q9BSK2", 1.5376396248754793], ["Q9UIQ6", 1.5376396248754793], ["Q9UM00", 1.5376396248754793], ["Q9UMR5", 1.5376396248754793], ["P00403", 1.5248183397306079], ["P12236", 1.5248183397306079], ["P55786", 1.5248183397306079], ["Q7Z569", 1.5248183397306079], ["Q96GC9", 1.5248183397306079], ["Q96C01", 1.511921169632607], ["P07099", 1.4989473958627886], ["Q99733", 1.4989473958627886], ["O75845", 1.4858962903240147], ["P10644", 1.4858962903240147], ["P48449", 1.4858962903240147], ["Q8TCT9", 1.472767115384539], ["Q969E2", 1.472767115384539], ["Q07065", 1.4595591237186676], ["Q15904", 1.4595591237186676], ["Q9UJW0", 1.4595591237186676], ["O00231", 1.446271558144171], ["P04439", 1.446271558144171], ["P17900", 1.446271558144171], ["Q4J6C6", 1.446271558144171], ["Q53GQ0", 1.446271558144171], ["Q8IYS2", 1.446271558144171], ["Q9BQT8", 1.446271558144171], ["Q9Y619", 1.446271558144171], ["O75935", 1.4329036514563958], ["Q14257", 1.4329036514563958], ["Q5VZE5", 1.4329036514563958], ["Q92896", 1.4329036514563958], ["Q9UBR2", 1.4329036514563958], ["P04035", 1.419454626258951], ["Q9HCE1", 1.419454626258951], ["Q9Y277", 1.419454626258951], ["P53367", 1.4059236947909328], ["Q92674", 1.4059236947909328], ["Q9BTY2", 1.4059236947909328], ["Q9BW91", 1.4059236947909328], ["Q9Y3A3", 1.4059236947909328], ["Q9Y4P3", 1.4059236947909328], ["P19474", 1.392310058750564], ["P38435", 1.392310058750564], ["Q15043", 1.392310058750564], ["Q96SK2", 1.392310058750564], ["Q9Y2T2", 1.392310058750564], ["O15260", 1.3786129091151909], ["P22830", 1.3786129091151909], ["P53365", 1.3786129091151909], ["Q8IV08", 1.3786129091151909], ["Q9BV86", 1.3786129091151909], ["O14773", 1.3648314259575298], ["P02786", 1.3648314259575298], ["P50402", 1.3648314259575298], ["P48723", 1.3509647782580774], ["P53611", 1.3509647782580774], ["Q9BTE7", 1.3509647782580774], ["Q9NVH1", 1.3509647782580774], ["A0AVF1", 1.3370121237135937], ["P55209", 1.3370121237135937], ["Q16880", 1.3370121237135937], ["O15127", 1.3229726085415559], ["O43505", 1.3229726085415559], ["P57105", 1.3229726085415559], ["O75874", 1.3088453672804772], ["P33991", 1.3088453672804772], ["Q12959", 1.3088453672804772], ["Q15388", 1.3088453672804772], ["Q9UPN3", 1.3088453672804772], ["P57088", 1.2946295225860096], ["Q70UQ0", 1.2946295225860096], ["Q96A33", 1.2946295225860096], ["Q96RL7", 1.2946295225860096], ["Q9NX40", 1.2946295225860096], ["Q9NZ08", 1.2946295225860096], ["P35610", 1.280324185022697], ["Q9H2J7", 1.280324185022697], ["O94927", 1.2659284528512882], ["Q96L58", 1.2659284528512882], ["Q9H7E9", 1.2659284528512882], ["P06865", 1.2514414118114898], ["Q15125", 1.2514414118114898], ["Q6ZRP7", 1.2514414118114898], ["Q96CN7", 1.2514414118114898], ["Q9BPX6", 1.2514414118114898], ["P06280", 1.2368621349000533], ["P16435", 1.2368621349000533], ["P16615", 1.2368621349000533], ["Q6NUM9", 1.2221896821440608], ["Q9H3K2", 1.2221896821440608], ["O15269", 1.207423100369303], ["P84157", 1.207423100369303], ["Q14728", 1.207423100369303], ["Q15907", 1.207423100369303], ["Q8N8N7", 1.207423100369303], ["Q9Y5X1", 1.207423100369303], ["P11279", 1.1925614229636166], ["P15586", 1.1925614229636166], ["Q8WVQ1", 1.1925614229636166], ["Q9GZY8", 1.1925614229636166], ["P31751", 1.1776036696350574], ["P48735", 1.1776036696350574], ["Q92544", 1.1776036696350574], ["Q9BT22", 1.1776036696350574], ["P35613", 1.162548846164761], ["Q8NF37", 1.162548846164761], ["Q96HA7", 1.162548846164761], ["P68371", 1.1473959441543768], ["Q99808", 1.1473959441543768], ["Q9BY49", 1.1473959441543768], ["O75448", 1.1321439407679112], ["P82933", 1.1321439407679112], ["Q12893", 1.1321439407679112], ["Q2TAA5", 1.1321439407679112], ["Q6UW68", 1.1321439407679112], ["Q8IWA4", 1.1321439407679112], ["Q92542", 1.1321439407679112], ["Q969Q5", 1.1321439407679112], ["Q9UBU6", 1.1321439407679112], ["Q9Y512", 1.1321439407679112], ["P52292", 1.1167917984678513], ["Q6NUQ4", 1.1167917984678513], ["Q9BUR5", 1.1167917984678513], ["Q9NPA0", 1.1167917984678513], ["O00584", 1.1013384647454063], ["P12235", 1.1013384647454063], ["P35269", 1.1013384647454063], ["P35790", 1.1013384647454063], ["P42858", 1.1013384647454063], ["Q16625", 1.1013384647454063], ["Q92604", 1.1013384647454063], ["P42167", 1.0857828718447309], ["Q7L576", 1.0857828718447309], ["Q99538", 1.0857828718447309], ["Q9NZ01", 1.0857828718447309], ["O95249", 1.070123936480939], ["Q9NR50", 1.070123936480939], ["O00443", 1.0543605595517835], ["O15258", 1.0543605595517835], ["P00374", 1.0543605595517835], ["P21912", 1.0543605595517835], ["Q13190", 1.0543605595517835], ["Q16611", 1.0543605595517835], ["Q5T9A4", 1.0543605595517835], ["Q96DM3", 1.0543605595517835], ["Q96IX5", 1.0543605595517835], ["Q99442", 1.0543605595517835], ["O00767", 1.0384916258428032], ["P05141", 1.0384916258428032], ["Q16706", 1.0384916258428032], ["Q6DKK2", 1.0384916258428032], ["Q92820", 1.0384916258428032], ["Q99640", 1.0384916258428032], ["Q15058", 1.0225160037257737], ["Q99805", 1.0225160037257737], ["Q9H490", 1.0225160037257737], ["Q9NVI7", 1.0225160037257737], ["Q9UBM7", 1.0225160037257737], ["O00264", 1.006432544850282], ["O43852", 1.006432544850282], ["O95429", 1.006432544850282], ["O95864", 1.006432544850282], ["Q6P4Q7", 1.006432544850282], ["Q7Z4H7", 1.006432544850282], ["Q9BSH5", 1.006432544850282], ["Q9BUF5", 1.006432544850282], ["Q9UHD9", 1.006432544850282], ["P26583", 0.9902400838282385], ["P28072", 0.9902400838282385], ["P62266", 0.9902400838282385], ["Q14C86", 0.9902400838282385], ["Q6PD62", 0.9902400838282385], ["Q6UWP7", 0.9902400838282385], ["Q96PC5", 0.9902400838282385], ["Q96SY0", 0.9902400838282385], ["Q9UGN5", 0.9902400838282385], ["O00154", 0.9739374379111466], ["P04350", 0.9739374379111466], ["P49748", 0.9739374379111466], ["Q15024", 0.9739374379111466], ["Q5SNT2", 0.9739374379111466], ["Q7Z6M1", 0.9739374379111466], ["Q8TEX9", 0.9739374379111466], ["Q9Y3E0", 0.9739374379111466], ["Q9Y5L0", 0.9739374379111466], ["O60476", 0.9575234066599015], ["O95721", 0.9575234066599015], ["P04066", 0.9575234066599015], ["P07437", 0.9575234066599015], ["P60900", 0.9575234066599015], ["Q14534", 0.9575234066599015], ["Q9BVA1", 0.9575234066599015], ["Q9HC21", 0.9575234066599015], ["Q9NWM8", 0.9575234066599015], ["A1L0T0", 0.9409967716069575], ["O14737", 0.9409967716069575], ["P42345", 0.9409967716069575], ["Q8IYU8", 0.9409967716069575], ["Q99797", 0.9409967716069575], ["Q9NPJ6", 0.9409967716069575], ["O15400", 0.9243562959106226], ["O43615", 0.9243562959106226], ["O95674", 0.9243562959106226], ["P46934", 0.9243562959106226], ["P49755", 0.9243562959106226], ["P56385", 0.9243562959106226], ["P62191", 0.9243562959106226], ["Q12981", 0.9243562959106226], ["Q15067", 0.9243562959106226], ["Q5KU26", 0.9243562959106226], ["Q8WVV9", 0.9243562959106226], ["Q96RR1", 0.9243562959106226], ["Q9H3N1", 0.9243562959106226], ["Q9H4A6", 0.9243562959106226], ["Q9H7Z7", 0.9243562959106226], ["Q9UJS0", 0.9243562959106226], ["A8MXV4", 0.9076007240012801], ["O60313", 0.9076007240012801], ["Q13011", 0.9076007240012801], ["Q32P28", 0.9076007240012801], ["Q86VI3", 0.9076007240012801], ["Q96DB5", 0.9076007240012801], ["Q96P70", 0.9076007240012801], ["O15126", 0.8907287812193003], ["O75976", 0.8907287812193003], ["P05067", 0.8907287812193003], ["P06493", 0.8907287812193003], ["P55735", 0.8907287812193003], ["Q29RF7", 0.8907287812193003], ["Q99735", 0.8907287812193003], ["Q9BT78", 0.8907287812193003], ["Q9BVK6", 0.8907287812193003], ["Q9Y5P6", 0.8907287812193003], ["O43598", 0.8737391734444331], ["P30876", 0.8737391734444331], ["P47985", 0.8737391734444331], ["Q6UXV4", 0.8737391734444331], ["Q96K12", 0.8737391734444331], ["Q9H2H8", 0.8737391734444331], ["Q9H4M9", 0.8737391734444331], ["Q9UMX5", 0.8737391734444331], ["O76024", 0.8566305867164241], ["P10321", 0.8566305867164241], ["P53701", 0.8566305867164241], ["P61916", 0.8566305867164241], ["P84085", 0.8566305867164241], ["Q00013", 0.8566305867164241], ["Q9UKA9", 0.8566305867164241], ["O00625", 0.8394016868466264], ["O14828", 0.8394016868466264], ["O15111", 0.8394016868466264], ["O43149", 0.8394016868466264], ["O43592", 0.8394016868466264], ["P61421", 0.8394016868466264], ["Q07864", 0.8394016868466264], ["Q13641", 0.8394016868466264], ["Q15021", 0.8394016868466264], ["Q5T2R2", 0.8394016868466264], ["Q7Z3C6", 0.8394016868466264], ["Q8NHH9", 0.8394016868466264], ["Q96R06", 0.8394016868466264], ["Q96S66", 0.8394016868466264], ["Q9BXP2", 0.8394016868466264], ["Q9Y6Y8", 0.8394016868466264], ["O43396", 0.8220511190203319], ["O60831", 0.8220511190203319], ["P07196", 0.8220511190203319], ["P55060", 0.8220511190203319], ["P62942", 0.8220511190203319], ["Q02252", 0.8220511190203319], ["Q9BTV4", 0.8220511190203319], ["Q9NRN7", 0.8220511190203319], ["O95782", 0.8045775073895869], ["P46020", 0.8045775073895869], ["P53634", 0.8045775073895869], ["Q01105", 0.8045775073895869], ["Q10471", 0.8045775073895869], ["Q12907", 0.8045775073895869], ["Q14566", 0.8045775073895869], ["Q86UL3", 0.8045775073895869], ["Q86V85", 0.8045775073895869], ["Q9UBB4", 0.8045775073895869], ["P28074", 0.7869794546562088], ["P39023", 0.7869794546562088], ["Q10713", 0.7869794546562088], ["Q14667", 0.7869794546562088], ["Q15120", 0.7869794546562088], ["Q8N6H7", 0.7869794546562088], ["Q8NBN7", 0.7869794546562088], ["Q8WWC4", 0.7869794546562088], ["Q9BRF8", 0.7869794546562088], ["Q9H1A4", 0.7869794546562088], ["O43808", 0.7692555416447295], ["O75419", 0.7692555416447295], ["P61289", 0.7692555416447295], ["P62917", 0.7692555416447295], ["P78318", 0.7692555416447295], ["Q7L8L6", 0.7692555416447295], ["Q8N5M9", 0.7692555416447295], ["Q9Y371", 0.7692555416447295], ["Q9Y3A6", 0.7692555416447295], ["O43819", 0.7514043268649677], ["P28288", 0.7514043268649677], ["P52789", 0.7514043268649677], ["Q13724", 0.7514043268649677], ["Q8TAG9", 0.7514043268649677], ["Q92643", 0.7514043268649677], ["Q9BU89", 0.7514043268649677], ["Q9BYT8", 0.7514043268649677], ["Q9H223", 0.7514043268649677], ["Q9NR31", 0.7514043268649677], ["Q9P035", 0.7514043268649677], ["Q9UI14", 0.7514043268649677], ["O15397", 0.7334243460639536], ["O75746", 0.7334243460639536], ["O75915", 0.7334243460639536], ["P17152", 0.7334243460639536], ["P61619", 0.7334243460639536], ["P62820", 0.7334243460639536], ["Q06787", 0.7334243460639536], ["Q15005", 0.7334243460639536], ["Q16537", 0.7334243460639536], ["Q92804", 0.7334243460639536], ["Q96M89", 0.7334243460639536], ["Q9HC38", 0.7334243460639536], ["Q9Y2X7", 0.7334243460639536], ["Q9Y305", 0.7334243460639536], ["O00488", 0.7153141117668748], ["O14654", 0.7153141117668748], ["P21964", 0.7153141117668748], ["P54619", 0.7153141117668748], ["P55327", 0.7153141117668748], ["P56377", 0.7153141117668748], ["Q00765", 0.7153141117668748], ["Q14674", 0.7153141117668748], ["Q15382", 0.7153141117668748], ["Q5XKP0", 0.7153141117668748], ["Q8NBQ5", 0.7153141117668748], ["Q9NUD5", 0.7153141117668748], ["O43242", 0.6970721128067479], ["O43865", 0.6970721128067479], ["O95155", 0.6970721128067479], ["P13674", 0.6970721128067479], ["P31942", 0.6970721128067479], ["Q3ZCQ8", 0.6970721128067479], ["Q6IN85", 0.6970721128067479], ["Q6ZXV5", 0.6970721128067479], ["Q86UY6", 0.6970721128067479], ["Q96SZ6", 0.6970721128067479], ["Q99584", 0.6970721128067479], ["Q9GZS3", 0.6970721128067479], ["Q9NWT6", 0.6970721128067479], ["O95870", 0.6786968138424812], ["P08670", 0.6786968138424812], ["P09455", 0.6786968138424812], ["P11717", 0.6786968138424812], ["P18074", 0.6786968138424812], ["P28070", 0.6786968138424812], ["P61927", 0.6786968138424812], ["P78537", 0.6786968138424812], ["Q68CQ4", 0.6786968138424812], ["Q96CS2", 0.6786968138424812], ["Q96HY6", 0.6786968138424812], ["Q96RT7", 0.6786968138424812], ["Q9H2M9", 0.6786968138424812], ["O15228", 0.6601866548649779], ["O60506", 0.6601866548649779], ["P20020", 0.6601866548649779], ["P37268", 0.6601866548649779], ["P38571", 0.6601866548649779], ["P43034", 0.6601866548649779], ["P49366", 0.6601866548649779], ["Q15154", 0.6601866548649779], ["Q8N1F7", 0.6601866548649779], ["Q8TCJ2", 0.6601866548649779], ["Q96FZ7", 0.6601866548649779], ["Q96LJ7", 0.6601866548649779], ["Q9H8H2", 0.6601866548649779], ["Q9NPL8", 0.6601866548649779], ["O75150", 0.6415400506909451], ["O95168", 0.6415400506909451], ["O95260", 0.6415400506909451], ["P25787", 0.6415400506909451], ["P52732", 0.6415400506909451], ["Q12874", 0.6415400506909451], ["Q6PGP7", 0.6415400506909451], ["Q7Z5K2", 0.6415400506909451], ["Q96AY3", 0.6415400506909451], ["Q96TC7", 0.6415400506909451], ["Q9H0C8", 0.6415400506909451], ["O14964", 0.6227553904440447], ["O15498", 0.6227553904440447], ["O43847", 0.6227553904440447], ["O75648", 0.6227553904440447], ["P20585", 0.6227553904440447], ["P49770", 0.6227553904440447], ["Q12834", 0.6227553904440447], ["Q13137", 0.6227553904440447], ["Q13395", 0.6227553904440447], ["Q13885", 0.6227553904440447], ["Q16134", 0.6227553904440447], ["Q8WVX9", 0.6227553904440447], ["Q9UID3", 0.6227553904440447], ["Q9Y580", 0.6227553904440447], ["A0FGR8", 0.6038310370230041], ["O15372", 0.6038310370230041], ["O43681", 0.6038310370230041], ["O75592", 0.6038310370230041], ["P14635", 0.6038310370230041], ["P40818", 0.6038310370230041], ["Q12769", 0.6038310370230041], ["Q16204", 0.6038310370230041], ["Q5JRX3", 0.6038310370230041], ["Q7Z5L9", 0.6038310370230041], ["Q86Y82", 0.6038310370230041], ["Q8NBU5", 0.6038310370230041], ["Q96TA1", 0.6038310370230041], ["Q9BRT2", 0.6038310370230041], ["Q9BU23", 0.6038310370230041], ["O14979", 0.5847653265563068], ["P20645", 0.5847653265563068], ["P23246", 0.5847653265563068], ["P46776", 0.5847653265563068], ["P55011", 0.5847653265563068], ["P61026", 0.5847653265563068], ["Q14168", 0.5847653265563068], ["Q14203", 0.5847653265563068], ["Q92990", 0.5847653265563068], ["Q9BTU6", 0.5847653265563068], ["Q9BTW9", 0.5847653265563068], ["Q9BXK5", 0.5847653265563068], ["Q9H857", 0.5847653265563068], ["Q9NTJ5", 0.5847653265563068], ["Q9UBU9", 0.5847653265563068], ["Q9Y4E8", 0.5847653265563068], ["Q9Y5X3", 0.5847653265563068], ["Q9Y6M9", 0.5847653265563068], ["O15360", 0.5655565678430635], ["O96008", 0.5655565678430635], ["P11802", 0.5655565678430635], ["P35244", 0.5655565678430635], ["P41440", 0.5655565678430635], ["P50851", 0.5655565678430635], ["P61019", 0.5655565678430635], ["P61923", 0.5655565678430635], ["Q01085", 0.5655565678430635], ["Q13895", 0.5655565678430635], ["Q16891", 0.5655565678430635], ["Q5J8M3", 0.5655565678430635], ["Q66K14", 0.5655565678430635], ["Q6PI78", 0.5655565678430635], ["Q86TU7", 0.5655565678430635], ["Q8TBX8", 0.5655565678430635], ["Q9BXS5", 0.5655565678430635], ["Q9UQ16", 0.5655565678430635], ["O60921", 0.5462030417796385], ["P11274", 0.5462030417796385], ["P41227", 0.5462030417796385], ["P53999", 0.5462030417796385], ["P61313", 0.5462030417796385], ["Q12800", 0.5462030417796385], ["Q14789", 0.5462030417796385], ["Q7Z7E8", 0.5462030417796385], ["Q92621", 0.5462030417796385], ["Q96NB2", 0.5462030417796385], ["Q99623", 0.5462030417796385], ["Q99707", 0.5462030417796385], ["Q9NQZ5", 0.5462030417796385], ["Q9NRZ9", 0.5462030417796385], ["Q9NUQ2", 0.5462030417796385], ["Q9UH99", 0.5462030417796385], ["Q9Y5A7", 0.5462030417796385], ["O00505", 0.5267030007716262], ["O95295", 0.5267030007716262], ["P04843", 0.5267030007716262], ["P48729", 0.5267030007716262], ["P62910", 0.5267030007716262], ["Q08AM6", 0.5267030007716262], ["Q13509", 0.5267030007716262], ["Q15019", 0.5267030007716262], ["Q15437", 0.5267030007716262], ["Q8IVW6", 0.5267030007716262], ["Q8WXF1", 0.5267030007716262], ["Q96T37", 0.5267030007716262], ["Q9NVT9", 0.5267030007716262], ["Q9NX63", 0.5267030007716262], ["P31943", 0.5070546681307051], ["P55263", 0.5070546681307051], ["P61513", 0.5070546681307051], ["Q01433", 0.5070546681307051], ["Q13177", 0.5070546681307051], ["Q92541", 0.5070546681307051], ["Q9NTK5", 0.5070546681307051], ["Q9NVE7", 0.5070546681307051], ["Q9NXE4", 0.5070546681307051], ["Q9P0U4", 0.5070546681307051], ["Q9Y3Z3", 0.5070546681307051], ["Q9Y678", 0.5070546681307051], ["O75208", 0.48725623745593405], ["P05023", 0.48725623745593405], ["P61803", 0.48725623745593405], ["Q13546", 0.48725623745593405], ["Q14562", 0.48725623745593405], ["Q86YV9", 0.48725623745593405], ["Q969Z0", 0.48725623745593405], ["Q96L91", 0.48725623745593405], ["Q9NX14", 0.48725623745593405], ["Q9P253", 0.48725623745593405], ["Q9Y262", 0.48725623745593405], ["Q9Y4R8", 0.48725623745593405], ["A5YKK6", 0.46730587199900714], ["O75879", 0.46730587199900714], ["P06400", 0.46730587199900714], ["P07686", 0.46730587199900714], ["P08195", 0.46730587199900714], ["P24941", 0.46730587199900714], ["P25205", 0.46730587199900714], ["P53007", 0.46730587199900714], ["P78310", 0.46730587199900714], ["P83881", 0.46730587199900714], ["Q06323", 0.46730587199900714], ["Q14527", 0.46730587199900714], ["Q5TFE4", 0.46730587199900714], ["Q6IBS0", 0.46730587199900714], ["Q6NUQ1", 0.46730587199900714], ["Q6P1N0", 0.46730587199900714], ["Q8IXT5", 0.46730587199900714], ["Q92688", 0.46730587199900714], ["Q96CW5", 0.46730587199900714], ["Q9BW92", 0.46730587199900714], ["Q9H9Y2", 0.46730587199900714], ["Q9HCU5", 0.46730587199900714], ["Q9HDC9", 0.46730587199900714], ["Q9NUQ7", 0.46730587199900714], ["Q9Y4X5", 0.46730587199900714], ["O43707", 0.44720170401297976], ["O75937", 0.44720170401297976], ["O95456", 0.44720170401297976], ["P00390", 0.44720170401297976], ["P08574", 0.44720170401297976], ["P35241", 0.44720170401297976], ["P43246", 0.44720170401297976], ["P49593", 0.44720170401297976], ["P51571", 0.44720170401297976], ["P52565", 0.44720170401297976], ["Q01844", 0.44720170401297976], ["Q13045", 0.44720170401297976], ["Q13464", 0.44720170401297976], ["Q5T653", 0.44720170401297976], ["Q8NFF5", 0.44720170401297976], ["Q8NHQ9", 0.44720170401297976], ["Q9BWH2", 0.44720170401297976], ["Q9NR33", 0.44720170401297976], ["Q9NRF9", 0.44720170401297976], ["Q9NV56", 0.44720170401297976], ["Q9NZW5", 0.44720170401297976], ["Q9UBU8", 0.44720170401297976], ["Q9Y5Q9", 0.44720170401297976], ["O14880", 0.42694183408394704], ["O75822", 0.42694183408394704], ["O75955", 0.42694183408394704], ["P08243", 0.42694183408394704], ["P22695", 0.42694183408394704], ["P35611", 0.42694183408394704], ["P50570", 0.42694183408394704], ["Q12756", 0.42694183408394704], ["Q12899", 0.42694183408394704], ["Q13867", 0.42694183408394704], ["Q14699", 0.42694183408394704], ["Q15022", 0.42694183408394704], ["Q15286", 0.42694183408394704], ["Q6IAA8", 0.42694183408394704], ["Q8IY95", 0.42694183408394704], ["Q8TBQ9", 0.42694183408394704], ["Q96A65", 0.42694183408394704], ["Q9BV57", 0.42694183408394704], ["Q9BVG4", 0.42694183408394704], ["Q9BWH6", 0.42694183408394704], ["Q9NNW5", 0.42694183408394704], ["Q9NQG6", 0.42694183408394704], ["Q9NUJ1", 0.42694183408394704], ["Q9UJX4", 0.42694183408394704], ["Q9Y2L5", 0.42694183408394704], ["Q9Y5A9", 0.42694183408394704], ["Q9Y6M1", 0.42694183408394704], ["O14653", 0.40652433044515934], ["O15344", 0.40652433044515934], ["O43464", 0.40652433044515934], ["O60826", 0.40652433044515934], ["P09429", 0.40652433044515934], ["P27635", 0.40652433044515934], ["P35637", 0.40652433044515934], ["P39687", 0.40652433044515934], ["P47914", 0.40652433044515934], ["P49427", 0.40652433044515934], ["P49902", 0.40652433044515934], ["P55795", 0.40652433044515934], ["P62273", 0.40652433044515934], ["Q13257", 0.40652433044515934], ["Q13409", 0.40652433044515934], ["Q13561", 0.40652433044515934], ["Q15042", 0.40652433044515934], ["Q5T2T1", 0.40652433044515934], ["Q86U38", 0.40652433044515934], ["Q8IWJ2", 0.40652433044515934], ["Q8N8A6", 0.40652433044515934], ["Q96AX1", 0.40652433044515934], ["Q9BRT9", 0.40652433044515934], ["Q9BYC9", 0.40652433044515934], ["Q9H269", 0.40652433044515934], ["Q9NU22", 0.40652433044515934], ["Q9UJZ1", 0.40652433044515934], ["Q9Y5S2", 0.40652433044515934], ["P07384", 0.38594722827302785], ["P10398", 0.38594722827302785], ["P30154", 0.38594722827302785], ["P38159", 0.38594722827302785], ["P57678", 0.38594722827302785], ["P61163", 0.38594722827302785], ["P67809", 0.38594722827302785], ["P83436", 0.38594722827302785], ["Q02543", 0.38594722827302785], ["Q08722", 0.38594722827302785], ["Q13617", 0.38594722827302785], ["Q14166", 0.38594722827302785], ["Q14457", 0.38594722827302785], ["Q15375", 0.38594722827302785], ["Q16543", 0.38594722827302785], ["Q8IU60", 0.38594722827302785], ["Q8NCM8", 0.38594722827302785], ["Q8TED1", 0.38594722827302785], ["Q96KP4", 0.38594722827302785], ["Q99567", 0.38594722827302785], ["Q9H1E3", 0.38594722827302785], ["Q9H3S7", 0.38594722827302785], ["Q9NR28", 0.38594722827302785], ["Q9NRL3", 0.38594722827302785], ["Q9NV88", 0.38594722827302785], ["Q9NYV4", 0.38594722827302785], ["Q9UBD5", 0.38594722827302785], ["Q9UGP8", 0.38594722827302785], ["Q9UHY7", 0.38594722827302785], ["Q9UNK0", 0.38594722827302785], ["Q9Y450", 0.38594722827302785], ["Q9Y496", 0.38594722827302785], ["O15118", 0.36520852896444506], ["O43390", 0.36520852896444506], ["O75600", 0.36520852896444506], ["O94901", 0.36520852896444506], ["P07199", 0.36520852896444506], ["P11166", 0.36520852896444506], ["P19174", 0.36520852896444506], ["P27824", 0.36520852896444506], ["P31350", 0.36520852896444506], ["P49257", 0.36520852896444506], ["P61201", 0.36520852896444506], ["Q02878", 0.36520852896444506], ["Q02978", 0.36520852896444506], ["Q13416", 0.36520852896444506], ["Q14165", 0.36520852896444506], ["Q6NXE6", 0.36520852896444506], ["Q7L014", 0.36520852896444506], ["Q7Z2K6", 0.36520852896444506], ["Q8NE86", 0.36520852896444506], ["Q8WXH0", 0.36520852896444506], ["Q96F07", 0.36520852896444506], ["Q9H9B4", 0.36520852896444506], ["Q9NP72", 0.36520852896444506], ["Q9NTJ3", 0.36520852896444506], ["Q9NXF1", 0.36520852896444506], ["Q9UNF0", 0.36520852896444506], ["Q9Y394", 0.36520852896444506], ["O43395", 0.3443061993948582], ["P08397", 0.3443061993948582], ["P18858", 0.3443061993948582], ["P33527", 0.3443061993948582], ["P46779", 0.3443061993948582], ["P49406", 0.3443061993948582], ["P51665", 0.3443061993948582], ["P84098", 0.3443061993948582], ["Q13136", 0.3443061993948582], ["Q14574", 0.3443061993948582], ["Q14CX7", 0.3443061993948582], ["Q15014", 0.3443061993948582], ["Q15233", 0.3443061993948582], ["Q15650", 0.3443061993948582], ["Q15758", 0.3443061993948582], ["Q5VTR2", 0.3443061993948582], ["Q7Z478", 0.3443061993948582], ["Q96E39", 0.3443061993948582], ["Q9BXW7", 0.3443061993948582], ["Q9HD47", 0.3443061993948582], ["Q9NRG7", 0.3443061993948582], ["Q9NUQ8", 0.3443061993948582], ["Q9NVD7", 0.3443061993948582], ["Q9NVV4", 0.3443061993948582], ["Q9P0I2", 0.3443061993948582], ["Q9UHR6", 0.3443061993948582], ["Q9Y312", 0.3443061993948582], ["L0R6Q1", 0.32323817115644027], ["O60343", 0.32323817115644027], ["O60879", 0.32323817115644027], ["P18077", 0.32323817115644027], ["P19447", 0.32323817115644027], ["P30153", 0.32323817115644027], ["P30260", 0.32323817115644027], ["P40429", 0.32323817115644027], ["P98175", 0.32323817115644027], ["Q15738", 0.32323817115644027], ["Q16539", 0.32323817115644027], ["Q16836", 0.32323817115644027], ["Q4G176", 0.32323817115644027], ["Q86YQ8", 0.32323817115644027], ["Q8IUD2", 0.32323817115644027], ["Q8N3C0", 0.32323817115644027], ["Q8N3Z3", 0.32323817115644027], ["Q8TDW0", 0.32323817115644027], ["Q92692", 0.32323817115644027], ["Q92973", 0.32323817115644027], ["Q96TA2", 0.32323817115644027], ["Q9BQ70", 0.32323817115644027], ["Q9BZJ0", 0.32323817115644027], ["Q9H6E4", 0.32323817115644027], ["Q9UEY8", 0.32323817115644027], ["Q9Y285", 0.32323817115644027], ["Q9Y320", 0.32323817115644027], ["A3KN83", 0.30200233977580343], ["O75312", 0.30200233977580343], ["O95373", 0.30200233977580343], ["O95487", 0.30200233977580343], ["P00367", 0.30200233977580343], ["P36915", 0.30200233977580343], ["P46976", 0.30200233977580343], ["P52597", 0.30200233977580343], ["P52756", 0.30200233977580343], ["P78316", 0.30200233977580343], ["Q13217", 0.30200233977580343], ["Q13308", 0.30200233977580343], ["Q14012", 0.30200233977580343], ["Q15054", 0.30200233977580343], ["Q15418", 0.30200233977580343], ["Q6P1M0", 0.30200233977580343], ["Q8IUH3", 0.30200233977580343], ["Q8IYA6", 0.30200233977580343], ["Q8N3U4", 0.30200233977580343], ["Q8TC07", 0.30200233977580343], ["Q9BSJ2", 0.30200233977580343], ["Q9BWU0", 0.30200233977580343], ["Q9H0U4", 0.30200233977580343], ["Q9NRY4", 0.30200233977580343], ["Q9NS91", 0.30200233977580343], ["Q9ULH0", 0.30200233977580343], ["O00213", 0.28059656391052684], ["O14734", 0.28059656391052684], ["O94813", 0.28059656391052684], ["P07197", 0.28059656391052684], ["P17812", 0.28059656391052684], ["P20618", 0.28059656391052684], ["P25490", 0.28059656391052684], ["P33176", 0.28059656391052684], ["P40855", 0.28059656391052684], ["P45974", 0.28059656391052684], ["P49642", 0.28059656391052684], ["Q7Z460", 0.28059656391052684], ["Q96QK1", 0.28059656391052684], ["Q9BQ61", 0.28059656391052684], ["Q9BZ95", 0.28059656391052684], ["Q9NW68", 0.28059656391052684], ["Q9UHA3", 0.28059656391052684], ["Q9UHB9", 0.28059656391052684], ["Q9ULX3", 0.28059656391052684], ["Q9UNH7", 0.28059656391052684], ["Q9Y244", 0.28059656391052684], ["Q9Y296", 0.28059656391052684], ["O43818", 0.259018664523886], ["O60318", 0.259018664523886], ["P20338", 0.259018664523886], ["P35606", 0.259018664523886], ["P49207", 0.259018664523886], ["P51114", 0.259018664523886], ["P53990", 0.259018664523886], ["P98194", 0.259018664523886], ["Q05D32", 0.259018664523886], ["Q13151", 0.259018664523886], ["Q15018", 0.259018664523886], ["Q15436", 0.259018664523886], ["Q16851", 0.259018664523886], ["Q7Z406", 0.259018664523886], ["Q86VR2", 0.259018664523886], ["Q8NFH4", 0.259018664523886], ["Q8NFQ8", 0.259018664523886], ["Q8WUB8", 0.259018664523886], ["Q92616", 0.259018664523886], ["Q9BRJ7", 0.259018664523886], ["Q9H0B6", 0.259018664523886], ["Q9H8Y8", 0.259018664523886], ["Q9HCS7", 0.259018664523886], ["Q9NTI5", 0.259018664523886], ["Q9NVN8", 0.259018664523886], ["Q9P1Z2", 0.259018664523886], ["Q9P2J5", 0.259018664523886], ["Q9UL54", 0.259018664523886], ["Q9UNS2", 0.259018664523886], ["Q9UNY4", 0.259018664523886], ["Q9Y294", 0.259018664523886], ["Q9Y4B6", 0.259018664523886], ["Q9Y4W6", 0.259018664523886], ["Q9Y6X9", 0.259018664523886], ["A6NDU8", 0.23726642403703146], ["O00116", 0.23726642403703146], ["O14974", 0.23726642403703146], ["O43683", 0.23726642403703146], ["O60716", 0.23726642403703146], ["O75880", 0.23726642403703146], ["O94832", 0.23726642403703146], ["O95218", 0.23726642403703146], ["O95777", 0.23726642403703146], ["P04844", 0.23726642403703146], ["P05166", 0.23726642403703146], ["P09622", 0.23726642403703146], ["P22626", 0.23726642403703146], ["P35268", 0.23726642403703146], ["P36578", 0.23726642403703146], ["P42696", 0.23726642403703146], ["P49915", 0.23726642403703146], ["P52701", 0.23726642403703146], ["P59998", 0.23726642403703146], ["P61088", 0.23726642403703146], ["Q13813", 0.23726642403703146], ["Q14011", 0.23726642403703146], ["Q14344", 0.23726642403703146], ["Q6P1L8", 0.23726642403703146], ["Q6PJG6", 0.23726642403703146], ["Q86V48", 0.23726642403703146], ["Q8N163", 0.23726642403703146], ["Q8TBA6", 0.23726642403703146], ["Q96BW9", 0.23726642403703146], ["Q96CS3", 0.23726642403703146], ["Q96D71", 0.23726642403703146], ["Q96E29", 0.23726642403703146], ["Q9BRX8", 0.23726642403703146], ["Q9BVC6", 0.23726642403703146], ["Q9BYD1", 0.23726642403703146], ["Q9C0C9", 0.23726642403703146], ["Q9HD26", 0.23726642403703146], ["Q9NWS0", 0.23726642403703146], ["O00330", 0.21533758545793177], ["O15270", 0.21533758545793177], ["O60884", 0.21533758545793177], ["O75386", 0.21533758545793177], ["P07900", 0.21533758545793177], ["P11216", 0.21533758545793177], ["P12956", 0.21533758545793177], ["P18031", 0.21533758545793177], ["P33981", 0.21533758545793177], ["P41214", 0.21533758545793177], ["P48444", 0.21533758545793177], ["P48556", 0.21533758545793177], ["P52434", 0.21533758545793177], ["P61962", 0.21533758545793177], ["P61978", 0.21533758545793177], ["P62753", 0.21533758545793177], ["P78527", 0.21533758545793177], ["P82914", 0.21533758545793177], ["Q07955", 0.21533758545793177], ["Q13325", 0.21533758545793177], ["Q13547", 0.21533758545793177], ["Q14254", 0.21533758545793177], ["Q5SWX8", 0.21533758545793177], ["Q6DKJ4", 0.21533758545793177], ["Q6GQQ9", 0.21533758545793177], ["Q6P087", 0.21533758545793177], ["Q7Z7H8", 0.21533758545793177], ["Q8WVB6", 0.21533758545793177], ["Q8WZA0", 0.21533758545793177], ["Q969G3", 0.21533758545793177], ["Q9BQ95", 0.21533758545793177], ["Q9BRJ2", 0.21533758545793177], ["Q9BUK6", 0.21533758545793177], ["Q9HBH5", 0.21533758545793177], ["Q9Y2J2", 0.21533758545793177], ["Q9Y2S7", 0.21533758545793177], ["Q9Y2W6", 0.21533758545793177], ["Q9Y5Q8", 0.21533758545793177], ["A4D1P6", 0.19322985148629535], ["O00429", 0.19322985148629535], ["O14578", 0.19322985148629535], ["O14981", 0.19322985148629535], ["O43237", 0.19322985148629535], ["O75718", 0.19322985148629535], ["P15954", 0.19322985148629535], ["P27708", 0.19322985148629535], ["P28340", 0.19322985148629535], ["P46778", 0.19322985148629535], ["P53350", 0.19322985148629535], ["P54727", 0.19322985148629535], ["P82979", 0.19322985148629535], ["P83916", 0.19322985148629535], ["Q00325", 0.19322985148629535], ["Q6NUK1", 0.19322985148629535], ["Q6P3X3", 0.19322985148629535], ["Q6SZW1", 0.19322985148629535], ["Q7Z417", 0.19322985148629535], ["Q8IUR0", 0.19322985148629535], ["Q8IX18", 0.19322985148629535], ["Q8TD16", 0.19322985148629535], ["Q96KB5", 0.19322985148629535], ["Q9BWF3", 0.19322985148629535], ["Q9GZT3", 0.19322985148629535], ["Q9H078", 0.19322985148629535], ["Q9NSV4", 0.19322985148629535], ["Q9NXR7", 0.19322985148629535], ["Q9NXX6", 0.19322985148629535], ["Q9P0M9", 0.19322985148629535], ["Q9ULR0", 0.19322985148629535], ["Q9UPQ9", 0.19322985148629535], ["Q9Y2A7", 0.19322985148629535], ["Q9Y3U8", 0.19322985148629535], ["O60664", 0.17094088359372295], ["O60749", 0.17094088359372295], ["O75436", 0.17094088359372295], ["P06576", 0.17094088359372295], ["P19388", 0.17094088359372295], ["P28482", 0.17094088359372295], ["P33993", 0.17094088359372295], ["P40937", 0.17094088359372295], ["P49760", 0.17094088359372295], ["P51812", 0.17094088359372295], ["P54098", 0.17094088359372295], ["P62993", 0.17094088359372295], ["Q6IQ22", 0.17094088359372295], ["Q6P2Q9", 0.17094088359372295], ["Q8IWS0", 0.17094088359372295], ["Q8NC56", 0.17094088359372295], ["Q8WUX2", 0.17094088359372295], ["Q96DT7", 0.17094088359372295], ["Q96EA4", 0.17094088359372295], ["Q96KP1", 0.17094088359372295], ["Q96M27", 0.17094088359372295], ["Q99417", 0.17094088359372295], ["Q99729", 0.17094088359372295], ["Q9BXW9", 0.17094088359372295], ["Q9H4L4", 0.17094088359372295], ["Q9NQ48", 0.17094088359372295], ["Q9NUL7", 0.17094088359372295], ["Q9UBT7", 0.17094088359372295], ["Q9UDY2", 0.17094088359372295], ["Q9Y230", 0.17094088359372295], ["Q9Y3B2", 0.17094088359372295], ["Q9Y6G9", 0.17094088359372295], ["O14744", 0.1484683010782358], ["O60271", 0.1484683010782358], ["O60678", 0.1484683010782358], ["O60762", 0.1484683010782358], ["O60888", 0.1484683010782358], ["O96028", 0.1484683010782358], ["P18085", 0.1484683010782358], ["P34896", 0.1484683010782358], ["P51991", 0.1484683010782358], ["Q5JRA6", 0.1484683010782358], ["Q8N1G2", 0.1484683010782358], ["Q8NAN2", 0.1484683010782358], ["Q8NHP6", 0.1484683010782358], ["Q92620", 0.1484683010782358], ["Q96A35", 0.1484683010782358], ["Q96CX2", 0.1484683010782358], ["Q9BT17", 0.1484683010782358], ["Q9GZZ1", 0.1484683010782358], ["Q9H330", 0.1484683010782358], ["Q9H7B2", 0.1484683010782358], ["Q9H9E3", 0.1484683010782358], ["Q9NP64", 0.1484683010782358], ["Q9NQ88", 0.1484683010782358], ["Q9UN81", 0.1484683010782358], ["Q9Y2V2", 0.1484683010782358], ["O00267", 0.12580968009238108], ["O00410", 0.12580968009238108], ["O14929", 0.12580968009238108], ["O15164", 0.12580968009238108], ["O75113", 0.12580968009238108], ["O75165", 0.12580968009238108], ["O95486", 0.12580968009238108], ["P08238", 0.12580968009238108], ["P09669", 0.12580968009238108], ["P30837", 0.12580968009238108], ["P48507", 0.12580968009238108], ["P56134", 0.12580968009238108], ["P62826", 0.12580968009238108], ["P62841", 0.12580968009238108], ["P78559", 0.12580968009238108], ["Q00839", 0.12580968009238108], ["Q03701", 0.12580968009238108], ["Q14331", 0.12580968009238108], ["Q14691", 0.12580968009238108], ["Q15427", 0.12580968009238108], ["Q16352", 0.12580968009238108], ["Q16795", 0.12580968009238108], ["Q5C9Z4", 0.12580968009238108], ["Q5VYK3", 0.12580968009238108], ["Q7Z3U7", 0.12580968009238108], ["Q8N684", 0.12580968009238108], ["Q8WTW3", 0.12580968009238108], ["Q92538", 0.12580968009238108], ["Q96DH6", 0.12580968009238108], ["Q96EY8", 0.12580968009238108], ["Q96P11", 0.12580968009238108], ["Q99543", 0.12580968009238108], ["Q9BV19", 0.12580968009238108], ["Q9H267", 0.12580968009238108], ["Q9H488", 0.12580968009238108], ["Q9NSD9", 0.12580968009238108], ["Q9NVZ3", 0.12580968009238108], ["Q9NYY8", 0.12580968009238108], ["Q9P287", 0.12580968009238108], ["Q9UJX2", 0.12580968009238108], ["Q9UL46", 0.12580968009238108], ["Q9UQE7", 0.12580968009238108], ["Q9Y276", 0.12580968009238108], ["Q9Y5Y2", 0.12580968009238108], ["Q9Y6K9", 0.12580968009238108], ["O00139", 0.10296255264400622], ["O00483", 0.10296255264400622], ["O14757", 0.10296255264400622], ["O14786", 0.10296255264400622], ["O15067", 0.10296255264400622], ["O60524", 0.10296255264400622], ["O75818", 0.10296255264400622], ["P29372", 0.10296255264400622], ["P48739", 0.10296255264400622], ["P49736", 0.10296255264400622], ["P50748", 0.10296255264400622], ["P51116", 0.10296255264400622], ["P51532", 0.10296255264400622], ["P53004", 0.10296255264400622], ["P61106", 0.10296255264400622], ["P83111", 0.10296255264400622], ["Q07020", 0.10296255264400622], ["Q12768", 0.10296255264400622], ["Q13144", 0.10296255264400622], ["Q15555", 0.10296255264400622], ["Q15814", 0.10296255264400622], ["Q2NL82", 0.10296255264400622], ["Q6P2P2", 0.10296255264400622], ["Q7Z7K6", 0.10296255264400622], ["Q8TB37", 0.10296255264400622], ["Q8TCG1", 0.10296255264400622], ["Q8WVM8", 0.10296255264400622], ["Q92600", 0.10296255264400622], ["Q96AC1", 0.10296255264400622], ["Q96RU2", 0.10296255264400622], ["Q9NVI1", 0.10296255264400622], ["Q9P2R3", 0.10296255264400622], ["Q9UJA5", 0.10296255264400622], ["Q9UJV9", 0.10296255264400622], ["Q9ULI0", 0.10296255264400622], ["Q9UPT8", 0.10296255264400622], ["Q9Y3D3", 0.10296255264400622], ["Q9Y4A5", 0.10296255264400622], ["Q9Y547", 0.10296255264400622], ["Q9Y5L4", 0.10296255264400622], ["O00541", 0.07992440556882748], ["O14617", 0.07992440556882748], ["O43399", 0.07992440556882748], ["O60841", 0.07992440556882748], ["O75792", 0.07992440556882748], ["O95478", 0.07992440556882748], ["P16989", 0.07992440556882748], ["P21399", 0.07992440556882748], ["P23378", 0.07992440556882748], ["P33992", 0.07992440556882748], ["P42025", 0.07992440556882748], ["P42166", 0.07992440556882748], ["P48651", 0.07992440556882748], ["P49321", 0.07992440556882748], ["P51149", 0.07992440556882748], ["P55039", 0.07992440556882748], ["P62847", 0.07992440556882748], ["P85037", 0.07992440556882748], ["Q07157", 0.07992440556882748], ["Q13057", 0.07992440556882748], ["Q14241", 0.07992440556882748], ["Q2VPK5", 0.07992440556882748], ["Q53H12", 0.07992440556882748], ["Q86U90", 0.07992440556882748], ["Q86V21", 0.07992440556882748], ["Q8NCA5", 0.07992440556882748], ["Q8NE71", 0.07992440556882748], ["Q8TED0", 0.07992440556882748], ["Q8TF05", 0.07992440556882748], ["Q96DF8", 0.07992440556882748], ["Q96FW1", 0.07992440556882748], ["Q96FZ2", 0.07992440556882748], ["Q96SI9", 0.07992440556882748], ["Q99627", 0.07992440556882748], ["Q9BWS9", 0.07992440556882748], ["Q9HB71", 0.07992440556882748], ["Q9NRX1", 0.07992440556882748], ["Q9UII2", 0.07992440556882748], ["Q9UKG1", 0.07992440556882748], ["Q9Y2X0", 0.07992440556882748], ["O00203", 0.0566926794738131], ["O00471", 0.0566926794738131], ["O15504", 0.0566926794738131], ["O94826", 0.0566926794738131], ["O94874", 0.0566926794738131], ["P06737", 0.0566926794738131], ["P23193", 0.0566926794738131], ["P23396", 0.0566926794738131], ["P26368", 0.0566926794738131], ["P30414", 0.0566926794738131], ["P46940", 0.0566926794738131], ["P51659", 0.0566926794738131], ["P60866", 0.0566926794738131], ["P62263", 0.0566926794738131], ["Q01082", 0.0566926794738131], ["Q05086", 0.0566926794738131], ["Q12931", 0.0566926794738131], ["Q13630", 0.0566926794738131], ["Q14103", 0.0566926794738131], ["Q14126", 0.0566926794738131], ["Q16637", 0.0566926794738131], ["Q3B7T1", 0.0566926794738131], ["Q5JTV8", 0.0566926794738131], ["Q5VV42", 0.0566926794738131], ["Q5VW32", 0.0566926794738131], ["Q86UP2", 0.0566926794738131], ["Q8IWV7", 0.0566926794738131], ["Q8NEM2", 0.0566926794738131], ["Q8TC12", 0.0566926794738131], ["Q969V3", 0.0566926794738131], ["Q96AE4", 0.0566926794738131], ["Q96CW1", 0.0566926794738131], ["Q96GW9", 0.0566926794738131], ["Q96JJ3", 0.0566926794738131], ["Q96MW5", 0.0566926794738131], ["Q9P258", 0.0566926794738131], ["Q9UHR5", 0.0566926794738131], ["Q9Y3A2", 0.0566926794738131], ["Q9Y483", 0.0566926794738131], ["A2RRP1", 0.03326476765043723], ["A6NHR9", 0.03326476765043723], ["O60306", 0.03326476765043723], ["O75340", 0.03326476765043723], ["P11908", 0.03326476765043723], ["P22033", 0.03326476765043723], ["P35573", 0.03326476765043723], ["P35658", 0.03326476765043723], ["P51809", 0.03326476765043723], ["P54886", 0.03326476765043723], ["P62241", 0.03326476765043723], ["Q07021", 0.03326476765043723], ["Q08J23", 0.03326476765043723], ["Q12797", 0.03326476765043723], ["Q12996", 0.03326476765043723], ["Q13620", 0.03326476765043723], ["Q14152", 0.03326476765043723], ["Q14839", 0.03326476765043723], ["Q5T6V5", 0.03326476765043723], ["Q5VTL8", 0.03326476765043723], ["Q68EM7", 0.03326476765043723], ["Q6PKG0", 0.03326476765043723], ["Q7Z4V5", 0.03326476765043723], ["Q8IXI1", 0.03326476765043723], ["Q8IY67", 0.03326476765043723], ["Q8IYR2", 0.03326476765043723], ["Q92599", 0.03326476765043723], ["Q96GA3", 0.03326476765043723], ["Q96PU8", 0.03326476765043723], ["Q96RP9", 0.03326476765043723], ["Q9BZZ5", 0.03326476765043723], ["Q9H1K1", 0.03326476765043723], ["Q9H5V9", 0.03326476765043723], ["Q9H9T3", 0.03326476765043723], ["Q9HAV4", 0.03326476765043723], ["Q9HBM1", 0.03326476765043723], ["Q9HCC0", 0.03326476765043723], ["Q9NVJ2", 0.03326476765043723], ["Q9NW82", 0.03326476765043723], ["Q9NWX5", 0.03326476765043723], ["Q9UKF6", 0.03326476765043723], ["O14802", 0.009638014956759703], ["O15027", 0.009638014956759703], ["O15347", 0.009638014956759703], ["O60568", 0.009638014956759703], ["O75223", 0.009638014956759703], ["P15311", 0.009638014956759703], ["P19784", 0.009638014956759703], ["P25054", 0.009638014956759703], ["P49327", 0.009638014956759703], ["P52948", 0.009638014956759703], ["P61254", 0.009638014956759703], ["P62995", 0.009638014956759703], ["P83731", 0.009638014956759703], ["Q00577", 0.009638014956759703], ["Q12846", 0.009638014956759703], ["Q14157", 0.009638014956759703], ["Q14498", 0.009638014956759703], ["Q15008", 0.009638014956759703], ["Q15036", 0.009638014956759703], ["Q15293", 0.009638014956759703], ["Q4KMP7", 0.009638014956759703], ["Q53GS9", 0.009638014956759703], ["Q5JTZ9", 0.009638014956759703], ["Q7Z6E9", 0.009638014956759703], ["Q86XP3", 0.009638014956759703], ["Q8IYI6", 0.009638014956759703], ["Q8NFH5", 0.009638014956759703], ["Q8TAE8", 0.009638014956759703], ["Q8WUA2", 0.009638014956759703], ["Q8WYA6", 0.009638014956759703], ["Q96PK6", 0.009638014956759703], ["Q99436", 0.009638014956759703], ["Q99575", 0.009638014956759703], ["Q99741", 0.009638014956759703], ["Q9BSH4", 0.009638014956759703], ["Q9BT73", 0.009638014956759703], ["Q9BZF1", 0.009638014956759703], ["Q9H0D6", 0.009638014956759703], ["Q9H2J4", 0.009638014956759703], ["Q9H583", 0.009638014956759703], ["Q9NPH2", 0.009638014956759703], ["Q9NVM9", 0.009638014956759703], ["Q9NXV2", 0.009638014956759703], ["Q9UER7", 0.009638014956759703], ["Q9UHI6", 0.009638014956759703], ["Q9UPU5", 0.009638014956759703], ["Q9Y2R9", 0.009638014956759703], ["O14976", -0.014190283332690111], ["O15042", -0.014190283332690111], ["O15460", -0.014190283332690111], ["O75251", -0.014190283332690111], ["O75934", -0.014190283332690111], ["O95347", -0.014190283332690111], ["P08237", -0.014190283332690111], ["P20073", -0.014190283332690111], ["P22087", -0.014190283332690111], ["P35580", -0.014190283332690111], ["P36551", -0.014190283332690111], ["P42704", -0.014190283332690111], ["P46781", -0.014190283332690111], ["P49643", -0.014190283332690111], ["P51153", -0.014190283332690111], ["P53396", -0.014190283332690111], ["P61221", -0.014190283332690111], ["P62424", -0.014190283332690111], ["P63172", -0.014190283332690111], ["P78371", -0.014190283332690111], ["Q13185", -0.014190283332690111], ["Q14197", -0.014190283332690111], ["Q14692", -0.014190283332690111], ["Q15648", -0.014190283332690111], ["Q15723", -0.014190283332690111], ["Q2M2I8", -0.014190283332690111], ["Q53F19", -0.014190283332690111], ["Q5BKZ1", -0.014190283332690111], ["Q5JTH9", -0.014190283332690111], ["Q75QN2", -0.014190283332690111], ["Q8IXB1", -0.014190283332690111], ["Q8IZ69", -0.014190283332690111], ["Q8N0X7", -0.014190283332690111], ["Q8TDN6", -0.014190283332690111], ["Q969X6", -0.014190283332690111], ["Q96BQ5", -0.014190283332690111], ["Q96F63", -0.014190283332690111], ["Q96MU7", -0.014190283332690111], ["Q9BWJ5", -0.014190283332690111], ["Q9BZE1", -0.014190283332690111], ["Q9H2W6", -0.014190283332690111], ["Q9H3U1", -0.014190283332690111], ["Q9NTZ6", -0.014190283332690111], ["Q9NYU2", -0.014190283332690111], ["Q9UJC3", -0.014190283332690111], ["Q9UKK9", -0.014190283332690111], ["Q9UL63", -0.014190283332690111], ["Q9UNQ2", -0.014190283332690111], ["Q9Y266", -0.014190283332690111], ["Q9Y570", -0.014190283332690111], ["O00459", -0.03822288271037234], ["O14936", -0.03822288271037234], ["O43795", -0.03822288271037234], ["O75323", -0.03822288271037234], ["O75533", -0.03822288271037234], ["O75695", -0.03822288271037234], ["O95251", -0.03822288271037234], ["P01889", -0.03822288271037234], ["P11940", -0.03822288271037234], ["P20042", -0.03822288271037234], ["P22681", -0.03822288271037234], ["P26373", -0.03822288271037234], ["P35222", -0.03822288271037234], ["P35251", -0.03822288271037234], ["P42766", -0.03822288271037234], ["P43243", -0.03822288271037234], ["P50454", -0.03822288271037234], ["P51553", -0.03822288271037234], ["P62081", -0.03822288271037234], ["P62314", -0.03822288271037234], ["P62495", -0.03822288271037234], ["Q07866", -0.03822288271037234], ["Q14677", -0.03822288271037234], ["Q5PRF9", -0.03822288271037234], ["Q658Y4", -0.03822288271037234], ["Q6P6C2", -0.03822288271037234], ["Q86TP1", -0.03822288271037234], ["Q8N5L8", -0.03822288271037234], ["Q8ND04", -0.03822288271037234], ["Q92614", -0.03822288271037234], ["Q92974", -0.03822288271037234], ["Q96EY7", -0.03822288271037234], ["Q96S59", -0.03822288271037234], ["Q99570", -0.03822288271037234], ["Q9BUJ2", -0.03822288271037234], ["Q9BVI4", -0.03822288271037234], ["Q9BY77", -0.03822288271037234], ["Q9NRF8", -0.03822288271037234], ["Q9NVX2", -0.03822288271037234], ["Q9NYH9", -0.03822288271037234], ["O00411", -0.062462590653624604], ["O00571", -0.062462590653624604], ["O00743", -0.062462590653624604], ["O43670", -0.062462590653624604], ["O60231", -0.062462590653624604], ["O95239", -0.062462590653624604], ["O95630", -0.062462590653624604], ["O95999", -0.062462590653624604], ["P13010", -0.062462590653624604], ["P13798", -0.062462590653624604], ["P16383", -0.062462590653624604], ["P18206", -0.062462590653624604], ["P54577", -0.062462590653624604], ["P56545", -0.062462590653624604], ["P61009", -0.062462590653624604], ["P61353", -0.062462590653624604], ["P61960", -0.062462590653624604], ["Q12830", -0.062462590653624604], ["Q13596", -0.062462590653624604], ["Q15006", -0.062462590653624604], ["Q16513", -0.062462590653624604], ["Q6DKI1", -0.062462590653624604], ["Q8IYS1", -0.062462590653624604], ["Q8N183", -0.062462590653624604], ["Q8N766", -0.062462590653624604], ["Q8TF68", -0.062462590653624604], ["Q8WUM0", -0.062462590653624604], ["Q92665", -0.062462590653624604], ["Q92945", -0.062462590653624604], ["Q99598", -0.062462590653624604], ["Q9H019", -0.062462590653624604], ["Q9H2G2", -0.062462590653624604], ["Q9H814", -0.062462590653624604], ["Q9NPF5", -0.062462590653624604], ["Q9NQT5", -0.062462590653624604], ["Q9P2D3", -0.062462590653624604], ["Q9UEE9", -0.062462590653624604], ["Q9Y383", -0.062462590653624604], ["Q9Y3B4", -0.062462590653624604], ["Q9Y5B9", -0.062462590653624604], ["O14646", -0.08691226787820137], ["O14908", -0.08691226787820137], ["O14967", -0.08691226787820137], ["O43815", -0.08691226787820137], ["O75396", -0.08691226787820137], ["P18621", -0.08691226787820137], ["P19022", -0.08691226787820137], ["P26640", -0.08691226787820137], ["P31483", -0.08691226787820137], ["P33121", -0.08691226787820137], ["P46782", -0.08691226787820137], ["P48681", -0.08691226787820137], ["P49458", -0.08691226787820137], ["P51970", -0.08691226787820137], ["P53680", -0.08691226787820137], ["Q13451", -0.08691226787820137], ["Q15257", -0.08691226787820137], ["Q16222", -0.08691226787820137], ["Q5SRE5", -0.08691226787820137], ["Q5T8P6", -0.08691226787820137], ["Q5VSL9", -0.08691226787820137], ["Q86SX3", -0.08691226787820137], ["Q86TB9", -0.08691226787820137], ["Q8NBJ5", -0.08691226787820137], ["Q8WW12", -0.08691226787820137], ["Q96GX5", -0.08691226787820137], ["Q96HS1", -0.08691226787820137], ["Q9H2P0", -0.08691226787820137], ["Q9H6S0", -0.08691226787820137], ["Q9H936", -0.08691226787820137], ["Q9NWX6", -0.08691226787820137], ["Q9NYF8", -0.08691226787820137], ["Q9UBF8", -0.08691226787820137], ["Q9UJY4", -0.08691226787820137], ["Q9UK61", -0.08691226787820137], ["Q9ULT8", -0.08691226787820137], ["Q9Y4P1", -0.08691226787820137], ["O00566", -0.11157482962869282], ["O43172", -0.11157482962869282], ["O60508", -0.11157482962869282], ["O75431", -0.11157482962869282], ["O95793", -0.11157482962869282], ["O95801", -0.11157482962869282], ["P06744", -0.11157482962869282], ["P12270", -0.11157482962869282], ["P17706", -0.11157482962869282], ["P18124", -0.11157482962869282], ["P36543", -0.11157482962869282], ["P40939", -0.11157482962869282], ["P42566", -0.11157482962869282], ["P52272", -0.11157482962869282], ["P60228", -0.11157482962869282], ["P60953", -0.11157482962869282], ["P62258", -0.11157482962869282], ["P63167", -0.11157482962869282], ["Q00610", -0.11157482962869282], ["Q01804", -0.11157482962869282], ["Q02218", -0.11157482962869282], ["Q12788", -0.11157482962869282], ["Q13330", -0.11157482962869282], ["Q13573", -0.11157482962869282], ["Q14696", -0.11157482962869282], ["Q6IA86", -0.11157482962869282], ["Q7Z392", -0.11157482962869282], ["Q86WB0", -0.11157482962869282], ["Q8N2G8", -0.11157482962869282], ["Q8N9N2", -0.11157482962869282], ["Q8TAQ2", -0.11157482962869282], ["Q8WWQ0", -0.11157482962869282], ["Q92552", -0.11157482962869282], ["Q96AG4", -0.11157482962869282], ["Q96GM5", -0.11157482962869282], ["Q9H845", -0.11157482962869282], ["Q9NY61", -0.11157482962869282], ["Q9NYL9", -0.11157482962869282], ["Q9P015", -0.11157482962869282], ["Q9UIA9", -0.11157482962869282], ["Q9Y5S9", -0.11157482962869282], ["O14530", -0.13645324700708894], ["O95400", -0.13645324700708894], ["O95905", -0.13645324700708894], ["P04792", -0.13645324700708894], ["P07237", -0.13645324700708894], ["P07947", -0.13645324700708894], ["P14735", -0.13645324700708894], ["P26358", -0.13645324700708894], ["P29692", -0.13645324700708894], ["P30419", -0.13645324700708894], ["P31323", -0.13645324700708894], ["P36404", -0.13645324700708894], ["P43304", -0.13645324700708894], ["P46939", -0.13645324700708894], ["P49589", -0.13645324700708894], ["P51784", -0.13645324700708894], ["P52888", -0.13645324700708894], ["P60903", -0.13645324700708894], ["P61020", -0.13645324700708894], ["Q02809", -0.13645324700708894], ["Q13555", -0.13645324700708894], ["Q14151", -0.13645324700708894], ["Q14690", -0.13645324700708894], ["Q15637", -0.13645324700708894], ["Q15906", -0.13645324700708894], ["Q16181", -0.13645324700708894], ["Q16527", -0.13645324700708894], ["Q3LXA3", -0.13645324700708894], ["Q6P158", -0.13645324700708894], ["Q7KZ85", -0.13645324700708894], ["Q86WJ1", -0.13645324700708894], ["Q8N6T3", -0.13645324700708894], ["Q8NEJ9", -0.13645324700708894], ["Q92734", -0.13645324700708894], ["Q969H8", -0.13645324700708894], ["Q969N2", -0.13645324700708894], ["Q96GQ7", -0.13645324700708894], ["Q96I24", -0.13645324700708894], ["Q9BPZ3", -0.13645324700708894], ["Q9BSC4", -0.13645324700708894], ["Q9GZR7", -0.13645324700708894], ["Q9H0E9", -0.13645324700708894], ["Q9H1I8", -0.13645324700708894], ["Q9NT62", -0.13645324700708894], ["Q9NVP1", -0.13645324700708894], ["Q9NWT1", -0.13645324700708894], ["Q9NYZ3", -0.13645324700708894], ["Q9UHB6", -0.13645324700708894], ["Q9UHD1", -0.13645324700708894], ["Q9UJ83", -0.13645324700708894], ["Q9UKN8", -0.13645324700708894], ["Q9ULX6", -0.13645324700708894], ["Q9UNZ2", -0.13645324700708894], ["Q9Y3E5", -0.13645324700708894], ["Q9Y3T9", -0.13645324700708894], ["Q9Y5J9", -0.13645324700708894], ["O14776", -0.16155054834083413], ["O43747", -0.16155054834083413], ["O76021", -0.16155054834083413], ["O95602", -0.16155054834083413], ["P02545", -0.16155054834083413], ["P11413", -0.16155054834083413], ["P14174", -0.16155054834083413], ["P36776", -0.16155054834083413], ["P41229", -0.16155054834083413], ["P58107", -0.16155054834083413], ["P61086", -0.16155054834083413], ["P62244", -0.16155054834083413], ["P82930", -0.16155054834083413], ["Q00535", -0.16155054834083413], ["Q08945", -0.16155054834083413], ["Q12789", -0.16155054834083413], ["Q12849", -0.16155054834083413], ["Q12906", -0.16155054834083413], ["Q13310", -0.16155054834083413], ["Q13618", -0.16155054834083413], ["Q13769", -0.16155054834083413], ["Q14240", -0.16155054834083413], ["Q14697", -0.16155054834083413], ["Q15345", -0.16155054834083413], ["Q5T440", -0.16155054834083413], ["Q7L2E3", -0.16155054834083413], ["Q7Z3B4", -0.16155054834083413], ["Q8IV63", -0.16155054834083413], ["Q8IY17", -0.16155054834083413], ["Q8N6R0", -0.16155054834083413], ["Q8NBF2", -0.16155054834083413], ["Q8WUM4", -0.16155054834083413], ["Q93034", -0.16155054834083413], ["Q99471", -0.16155054834083413], ["Q9BZF3", -0.16155054834083413], ["Q9GZT8", -0.16155054834083413], ["Q9NVU7", -0.16155054834083413], ["Q9NZB2", -0.16155054834083413], ["Q9Y2Z2", -0.16155054834083413], ["Q9Y467", -0.16155054834083413], ["O00151", -0.18686982059176915], ["O00629", -0.18686982059176915], ["O43663", -0.18686982059176915], ["O43765", -0.18686982059176915], ["O75155", -0.18686982059176915], ["O75494", -0.18686982059176915], ["O95573", -0.18686982059176915], ["O95747", -0.18686982059176915], ["P13693", -0.18686982059176915], ["P13807", -0.18686982059176915], ["P47756", -0.18686982059176915], ["P47897", -0.18686982059176915], ["P49590", -0.18686982059176915], ["P49792", -0.18686982059176915], ["P49959", -0.18686982059176915], ["P63173", -0.18686982059176915], ["P81605", -0.18686982059176915], ["Q2TAA2", -0.18686982059176915], ["Q5T4S7", -0.18686982059176915], ["Q6NYC1", -0.18686982059176915], ["Q7Z434", -0.18686982059176915], ["Q7Z4H8", -0.18686982059176915], ["Q8WXX5", -0.18686982059176915], ["Q92905", -0.18686982059176915], ["Q96GD4", -0.18686982059176915], ["Q96P16", -0.18686982059176915], ["Q96T76", -0.18686982059176915], ["Q9BRP4", -0.18686982059176915], ["Q9BVQ7", -0.18686982059176915], ["Q9H3H1", -0.18686982059176915], ["Q9H3K6", -0.18686982059176915], ["Q9NVA2", -0.18686982059176915], ["Q9NY33", -0.18686982059176915], ["Q9NY93", -0.18686982059176915], ["Q9NYK5", -0.18686982059176915], ["Q9P0K7", -0.18686982059176915], ["Q9P0M6", -0.18686982059176915], ["Q9P275", -0.18686982059176915], ["Q9ULW0", -0.18686982059176915], ["O15091", -0.21241421080737602], ["O60573", -0.21241421080737602], ["O75683", -0.21241421080737602], ["O95453", -0.21241421080737602], ["P00387", -0.21241421080737602], ["P05771", -0.21241421080737602], ["P09960", -0.21241421080737602], ["P10606", -0.21241421080737602], ["P11177", -0.21241421080737602], ["P12814", -0.21241421080737602], ["P18615", -0.21241421080737602], ["P25685", -0.21241421080737602], ["P31930", -0.21241421080737602], ["P35232", -0.21241421080737602], ["P36542", -0.21241421080737602], ["P42224", -0.21241421080737602], ["P43487", -0.21241421080737602], ["P57740", -0.21241421080737602], ["P62906", -0.21241421080737602], ["P82663", -0.21241421080737602], ["P82675", -0.21241421080737602], ["Q12792", -0.21241421080737602], ["Q13283", -0.21241421080737602], ["Q13356", -0.21241421080737602], ["Q13616", -0.21241421080737602], ["Q14847", -0.21241421080737602], ["Q15003", -0.21241421080737602], ["Q15056", -0.21241421080737602], ["Q15149", -0.21241421080737602], ["Q5ST30", -0.21241421080737602], ["Q5VT66", -0.21241421080737602], ["Q6UVJ0", -0.21241421080737602], ["Q86UV5", -0.21241421080737602], ["Q86Y56", -0.21241421080737602], ["Q8N7H5", -0.21241421080737602], ["Q92575", -0.21241421080737602], ["Q92667", -0.21241421080737602], ["Q96F45", -0.21241421080737602], ["Q96QC0", -0.21241421080737602], ["Q96SB8", -0.21241421080737602], ["Q96ST3", -0.21241421080737602], ["Q99700", -0.21241421080737602], ["Q9BPW8", -0.21241421080737602], ["Q9BU76", -0.21241421080737602], ["Q9BW27", -0.21241421080737602], ["Q9BWD1", -0.21241421080737602], ["Q9HBK9", -0.21241421080737602], ["Q9UBW8", -0.21241421080737602], ["Q9UPN9", -0.21241421080737602], ["Q9Y2L1", -0.21241421080737602], ["Q9Y679", -0.21241421080737602], ["O00303", -0.23818692761586824], ["O00487", -0.23818692761586824], ["O15143", -0.23818692761586824], ["O43617", -0.23818692761586824], ["O95551", -0.23818692761586824], ["P08579", -0.23818692761586824], ["P08621", -0.23818692761586824], ["P09543", -0.23818692761586824], ["P09651", -0.23818692761586824], ["P15880", -0.23818692761586824], ["P16930", -0.23818692761586824], ["P17858", -0.23818692761586824], ["P21281", -0.23818692761586824], ["P22059", -0.23818692761586824], ["P26038", -0.23818692761586824], ["P26196", -0.23818692761586824], ["P26599", -0.23818692761586824], ["P33240", -0.23818692761586824], ["P36507", -0.23818692761586824], ["P50416", -0.23818692761586824], ["P54105", -0.23818692761586824], ["P62750", -0.23818692761586824], ["Q13868", -0.23818692761586824], ["Q14137", -0.23818692761586824], ["Q15813", -0.23818692761586824], ["Q66K74", -0.23818692761586824], ["Q69YN2", -0.23818692761586824], ["Q6UX07", -0.23818692761586824], ["Q71RC2", -0.23818692761586824], ["Q7Z4G4", -0.23818692761586824], ["Q8N442", -0.23818692761586824], ["Q8TEM1", -0.23818692761586824], ["Q93009", -0.23818692761586824], ["Q96IJ6", -0.23818692761586824], ["Q9BUQ8", -0.23818692761586824], ["Q9BYD6", -0.23818692761586824], ["Q9H0A0", -0.23818692761586824], ["Q9H2U1", -0.23818692761586824], ["Q9H6R4", -0.23818692761586824], ["Q9HC35", -0.23818692761586824], ["Q9NX74", -0.23818692761586824], ["Q9P2I0", -0.23818692761586824], ["Q9ULC4", -0.23818692761586824], ["Q9Y2Z4", -0.23818692761586824], ["Q9Y3P9", -0.23818692761586824], ["Q9Y4L1", -0.23818692761586824], ["Q9Y4W2", -0.23818692761586824], ["Q9Y5K6", -0.23818692761586824], ["Q9Y6E2", -0.23818692761586824], ["O00291", -0.26419124276665046], ["O60264", -0.26419124276665046], ["O75179", -0.26419124276665046], ["O75691", -0.26419124276665046], ["O76031", -0.26419124276665046], ["O94966", -0.26419124276665046], ["P04083", -0.26419124276665046], ["P10589", -0.26419124276665046], ["P16949", -0.26419124276665046], ["P20290", -0.26419124276665046], ["P30040", -0.26419124276665046], ["P31948", -0.26419124276665046], ["P35270", -0.26419124276665046], ["P39656", -0.26419124276665046], ["P40616", -0.26419124276665046], ["P40763", -0.26419124276665046], ["P54132", -0.26419124276665046], ["P55884", -0.26419124276665046], ["P61006", -0.26419124276665046], ["P61457", -0.26419124276665046], ["P62070", -0.26419124276665046], ["P62829", -0.26419124276665046], ["Q00688", -0.26419124276665046], ["Q01968", -0.26419124276665046], ["Q04637", -0.26419124276665046], ["Q04726", -0.26419124276665046], ["Q06210", -0.26419124276665046], ["Q10567", -0.26419124276665046], ["Q13200", -0.26419124276665046], ["Q13263", -0.26419124276665046], ["Q14204", -0.26419124276665046], ["Q14558", -0.26419124276665046], ["Q15645", -0.26419124276665046], ["Q15691", -0.26419124276665046], ["Q15785", -0.26419124276665046], ["Q15942", -0.26419124276665046], ["Q16763", -0.26419124276665046], ["Q2TAY7", -0.26419124276665046], ["Q6N075", -0.26419124276665046], ["Q86U44", -0.26419124276665046], ["Q86VM9", -0.26419124276665046], ["Q96EE3", -0.26419124276665046], ["Q96J02", -0.26419124276665046], ["Q96JB5", -0.26419124276665046], ["Q96Q89", -0.26419124276665046], ["Q9H0H5", -0.26419124276665046], ["Q9H4A4", -0.26419124276665046], ["Q9H9H4", -0.26419124276665046], ["Q9NR30", -0.26419124276665046], ["Q9NRL2", -0.26419124276665046], ["Q9UBF2", -0.26419124276665046], ["Q9ULK4", -0.26419124276665046], ["Q9Y263", -0.26419124276665046], ["Q9Y2R4", -0.26419124276665046], ["Q9Y613", -0.26419124276665046], ["O15213", -0.2904304927178063], ["O43776", -0.2904304927178063], ["O60341", -0.2904304927178063], ["O60566", -0.2904304927178063], ["O75489", -0.2904304927178063], ["P09884", -0.2904304927178063], ["P16885", -0.2904304927178063], ["P20339", -0.2904304927178063], ["P26885", -0.2904304927178063], ["P28289", -0.2904304927178063], ["P35579", -0.2904304927178063], ["P46783", -0.2904304927178063], ["P55196", -0.2904304927178063], ["P62701", -0.2904304927178063], ["Q00341", -0.2904304927178063], ["Q00534", -0.2904304927178063], ["Q04323", -0.2904304927178063], ["Q13418", -0.2904304927178063], ["Q13610", -0.2904304927178063], ["Q14258", -0.2904304927178063], ["Q5JSZ5", -0.2904304927178063], ["Q5M775", -0.2904304927178063], ["Q6NSI4", -0.2904304927178063], ["Q7L0Y3", -0.2904304927178063], ["Q7Z6Z7", -0.2904304927178063], ["Q8IUF8", -0.2904304927178063], ["Q8IX01", -0.2904304927178063], ["Q8WTT2", -0.2904304927178063], ["Q8WUX9", -0.2904304927178063], ["Q93008", -0.2904304927178063], ["Q96FV9", -0.2904304927178063], ["Q96HE7", -0.2904304927178063], ["Q96N67", -0.2904304927178063], ["Q96S52", -0.2904304927178063], ["Q9BQ39", -0.2904304927178063], ["Q9H0U3", -0.2904304927178063], ["Q9HAS0", -0.2904304927178063], ["Q9NQG5", -0.2904304927178063], ["Q9NUJ3", -0.2904304927178063], ["Q9NZI8", -0.2904304927178063], ["Q9UDR5", -0.2904304927178063], ["Q9UHY1", -0.2904304927178063], ["Q9UI12", -0.2904304927178063], ["Q9UKD2", -0.2904304927178063], ["Q9UKM9", -0.2904304927178063], ["Q9Y2Q9", -0.2904304927178063], ["O14497", -0.31690808027229783], ["O60488", -0.31690808027229783], ["O75400", -0.31690808027229783], ["O94776", -0.31690808027229783], ["P07355", -0.31690808027229783], ["P08708", -0.31690808027229783], ["P09496", -0.31690808027229783], ["P11233", -0.31690808027229783], ["P15927", -0.31690808027229783], ["P17987", -0.31690808027229783], ["P19525", -0.31690808027229783], ["P21127", -0.31690808027229783], ["P25325", -0.31690808027229783], ["P25705", -0.31690808027229783], ["P35237", -0.31690808027229783], ["P42285", -0.31690808027229783], ["P46926", -0.31690808027229783], ["P49354", -0.31690808027229783], ["P49790", -0.31690808027229783], ["P51398", -0.31690808027229783], ["P54709", -0.31690808027229783], ["P58546", -0.31690808027229783], ["P84103", -0.31690808027229783], ["Q01780", -0.31690808027229783], ["Q02790", -0.31690808027229783], ["Q03252", -0.31690808027229783], ["Q05682", -0.31690808027229783], ["Q13123", -0.31690808027229783], ["Q13162", -0.31690808027229783], ["Q16512", -0.31690808027229783], ["Q7L5N1", -0.31690808027229783], ["Q8IVS2", -0.31690808027229783], ["Q8IZ81", -0.31690808027229783], ["Q8N3X1", -0.31690808027229783], ["Q92576", -0.31690808027229783], ["Q92797", -0.31690808027229783], ["Q96A49", -0.31690808027229783], ["Q96K76", -0.31690808027229783], ["Q99536", -0.31690808027229783], ["Q99615", -0.31690808027229783], ["Q99848", -0.31690808027229783], ["Q9BS26", -0.31690808027229783], ["Q9NVH0", -0.31690808027229783], ["Q9UL15", -0.31690808027229783], ["Q9UM54", -0.31690808027229783], ["Q9Y3A5", -0.31690808027229783], ["O00178", -0.3436274762646461], ["O43252", -0.3436274762646461], ["O60287", -0.3436274762646461], ["O60832", -0.3436274762646461], ["O75821", -0.3436274762646461], ["O95163", -0.3436274762646461], ["O96017", -0.3436274762646461], ["P05387", -0.3436274762646461], ["P05455", -0.3436274762646461], ["P09661", -0.3436274762646461], ["P09874", -0.3436274762646461], ["P13984", -0.3436274762646461], ["P14923", -0.3436274762646461], ["P23368", -0.3436274762646461], ["P29218", -0.3436274762646461], ["P30520", -0.3436274762646461], ["P37837", -0.3436274762646461], ["P51148", -0.3436274762646461], ["P67870", -0.3436274762646461], ["P78344", -0.3436274762646461], ["P78549", -0.3436274762646461], ["P84243", -0.3436274762646461], ["Q06203", -0.3436274762646461], ["Q13098", -0.3436274762646461], ["Q13112", -0.3436274762646461], ["Q13564", -0.3436274762646461], ["Q14966", -0.3436274762646461], ["Q15061", -0.3436274762646461], ["Q15386", -0.3436274762646461], ["Q15435", -0.3436274762646461], ["Q16629", -0.3436274762646461], ["Q5TA45", -0.3436274762646461], ["Q5VWN6", -0.3436274762646461], ["Q6PJT7", -0.3436274762646461], ["Q7Z7L1", -0.3436274762646461], ["Q8IY81", -0.3436274762646461], ["Q8NI60", -0.3436274762646461], ["Q8TAT6", -0.3436274762646461], ["Q8TDD1", -0.3436274762646461], ["Q96EB1", -0.3436274762646461], ["Q9BQ75", -0.3436274762646461], ["Q9BTX7", -0.3436274762646461], ["Q9BV20", -0.3436274762646461], ["Q9BZE4", -0.3436274762646461], ["Q9H993", -0.3436274762646461], ["Q9NQ55", -0.3436274762646461], ["Q9NZM5", -0.3436274762646461], ["Q9P2N5", -0.3436274762646461], ["Q9UG63", -0.3436274762646461], ["Q9UNW1", -0.3436274762646461], ["Q9UPY3", -0.3436274762646461], ["Q9Y295", -0.3436274762646461], ["Q9Y2W1", -0.3436274762646461], ["Q9Y4C2", -0.3436274762646461], ["Q9Y4C8", -0.3436274762646461], ["O00170", -0.37059222129993374], ["O00754", -0.37059222129993374], ["O43432", -0.37059222129993374], ["O75347", -0.37059222129993374], ["O95394", -0.37059222129993374], ["P05412", -0.37059222129993374], ["P17480", -0.37059222129993374], ["P20674", -0.37059222129993374], ["P22061", -0.37059222129993374], ["P25440", -0.37059222129993374], ["P30566", -0.37059222129993374], ["P35080", -0.37059222129993374], ["P41240", -0.37059222129993374], ["P50991", -0.37059222129993374], ["P63218", -0.37059222129993374], ["Q02750", -0.37059222129993374], ["Q07666", -0.37059222129993374], ["Q08426", -0.37059222129993374], ["Q08752", -0.37059222129993374], ["Q13523", -0.37059222129993374], ["Q14353", -0.37059222129993374], ["Q14669", -0.37059222129993374], ["Q5SW79", -0.37059222129993374], ["Q5SY16", -0.37059222129993374], ["Q5TDH0", -0.37059222129993374], ["Q6YN16", -0.37059222129993374], ["Q86U86", -0.37059222129993374], ["Q86VP6", -0.37059222129993374], ["Q8IWZ3", -0.37059222129993374], ["Q8IX12", -0.37059222129993374], ["Q92499", -0.37059222129993374], ["Q92900", -0.37059222129993374], ["Q96HC4", -0.37059222129993374], ["Q99590", -0.37059222129993374], ["Q99832", -0.37059222129993374], ["Q9BSJ8", -0.37059222129993374], ["Q9BTE3", -0.37059222129993374], ["Q9H6U6", -0.37059222129993374], ["Q9H9Y6", -0.37059222129993374], ["Q9HAU5", -0.37059222129993374], ["Q9NPF4", -0.37059222129993374], ["Q9NPJ3", -0.37059222129993374], ["Q9NXV6", -0.37059222129993374], ["Q9P2E9", -0.37059222129993374], ["Q9UBT2", -0.37059222129993374], ["Q9UHV9", -0.37059222129993374], ["Q9UI10", -0.37059222129993374], ["Q9Y2W2", -0.37059222129993374], ["Q9Y3B8", -0.37059222129993374], ["O00217", -0.39780592754705757], ["O43290", -0.39780592754705757], ["O43809", -0.39780592754705757], ["O60763", -0.39780592754705757], ["O75643", -0.39780592754705757], ["O94906", -0.39780592754705757], ["P04637", -0.39780592754705757], ["P13861", -0.39780592754705757], ["P14618", -0.39780592754705757], ["P17980", -0.39780592754705757], ["P31689", -0.39780592754705757], ["P40938", -0.39780592754705757], ["P46734", -0.39780592754705757], ["P60520", -0.39780592754705757], ["P60983", -0.39780592754705757], ["P61158", -0.39780592754705757], ["P62857", -0.39780592754705757], ["P62899", -0.39780592754705757], ["Q02241", -0.39780592754705757], ["Q13084", -0.39780592754705757], ["Q14232", -0.39780592754705757], ["Q14738", -0.39780592754705757], ["Q15075", -0.39780592754705757], ["Q15334", -0.39780592754705757], ["Q7LBC6", -0.39780592754705757], ["Q7Z2W4", -0.39780592754705757], ["Q8IXI2", -0.39780592754705757], ["Q8IYB8", -0.39780592754705757], ["Q969T9", -0.39780592754705757], ["Q969V5", -0.39780592754705757], ["Q96GM8", -0.39780592754705757], ["Q96I25", -0.39780592754705757], ["Q96L73", -0.39780592754705757], ["Q99459", -0.39780592754705757], ["Q99747", -0.39780592754705757], ["Q9BU61", -0.39780592754705757], ["Q9BW19", -0.39780592754705757], ["Q9BZX2", -0.39780592754705757], ["Q9C0C2", -0.39780592754705757], ["Q9NRG9", -0.39780592754705757], ["Q9NWH9", -0.39780592754705757], ["Q9P032", -0.39780592754705757], ["Q9P2K5", -0.39780592754705757], ["Q9UBL3", -0.39780592754705757], ["Q9UBQ0", -0.39780592754705757], ["Q9UH62", -0.39780592754705757], ["Q9Y6A4", -0.39780592754705757], ["O14745", -0.4252722805882104], ["O60934", -0.4252722805882104], ["O75530", -0.4252722805882104], ["O95071", -0.4252722805882104], ["O95372", -0.4252722805882104], ["P07814", -0.4252722805882104], ["P11387", -0.4252722805882104], ["P14314", -0.4252722805882104], ["P35221", -0.4252722805882104], ["P41223", -0.4252722805882104], ["P42126", -0.4252722805882104], ["P46013", -0.4252722805882104], ["P51858", -0.4252722805882104], ["P62277", -0.4252722805882104], ["P63096", -0.4252722805882104], ["P78362", -0.4252722805882104], ["Q06124", -0.4252722805882104], ["Q08623", -0.4252722805882104], ["Q12802", -0.4252722805882104], ["Q13363", -0.4252722805882104], ["Q14683", -0.4252722805882104], ["Q15020", -0.4252722805882104], ["Q15459", -0.4252722805882104], ["Q16186", -0.4252722805882104], ["Q6Y7W6", -0.4252722805882104], ["Q7L266", -0.4252722805882104], ["Q7Z2W9", -0.4252722805882104], ["Q86X55", -0.4252722805882104], ["Q8IYB5", -0.4252722805882104], ["Q8N5N7", -0.4252722805882104], ["Q8NC60", -0.4252722805882104], ["Q8TBC4", -0.4252722805882104], ["Q8WWY3", -0.4252722805882104], ["Q9HB07", -0.4252722805882104], ["Q9NQH7", -0.4252722805882104], ["Q9NQS7", -0.4252722805882104], ["Q9NZN8", -0.4252722805882104], ["Q9ULC3", -0.4252722805882104], ["Q9Y2X3", -0.4252722805882104], ["O14965", -0.4529950413267082], ["O60216", -0.4529950413267082], ["O60493", -0.4529950413267082], ["O75832", -0.4529950413267082], ["O95232", -0.4529950413267082], ["O95336", -0.4529950413267082], ["P0DMV9", -0.4529950413267082], ["P11171", -0.4529950413267082], ["P14868", -0.4529950413267082], ["P15924", -0.4529950413267082], ["P16403", -0.4529950413267082], ["P18583", -0.4529950413267082], ["P31153", -0.4529950413267082], ["P57737", -0.4529950413267082], ["P62316", -0.4529950413267082], ["P62851", -0.4529950413267082], ["P63104", -0.4529950413267082], ["P63151", -0.4529950413267082], ["P84095", -0.4529950413267082], ["Q04206", -0.4529950413267082], ["Q15084", -0.4529950413267082], ["Q15404", -0.4529950413267082], ["Q15717", -0.4529950413267082], ["Q5JPH6", -0.4529950413267082], ["Q5T3I0", -0.4529950413267082], ["Q5VUA4", -0.4529950413267082], ["Q6PI48", -0.4529950413267082], ["Q7L2H7", -0.4529950413267082], ["Q92888", -0.4529950413267082], ["Q92979", -0.4529950413267082], ["Q96F86", -0.4529950413267082], ["Q9BRX5", -0.4529950413267082], ["Q9H6Z4", -0.4529950413267082], ["Q9HAV7", -0.4529950413267082], ["Q9NW64", -0.4529950413267082], ["Q9P031", -0.4529950413267082], ["Q9P0L0", -0.4529950413267082], ["Q9UJX5", -0.4529950413267082], ["Q9UKL0", -0.4529950413267082], ["Q9UN37", -0.4529950413267082], ["O14772", -0.4809780479553145], ["O14980", -0.4809780479553145], ["O43491", -0.4809780479553145], ["O43837", -0.4809780479553145], ["O60610", -0.4809780479553145], ["O75380", -0.4809780479553145], ["P52907", -0.4809780479553145], ["P53621", -0.4809780479553145], ["P54136", -0.4809780479553145], ["P55036", -0.4809780479553145], ["P61011", -0.4809780479553145], ["Q01813", -0.4809780479553145], ["Q13206", -0.4809780479553145], ["Q13557", -0.4809780479553145], ["Q14008", -0.4809780479553145], ["Q14315", -0.4809780479553145], ["Q53EL6", -0.4809780479553145], ["Q5F1R6", -0.4809780479553145], ["Q5VZL5", -0.4809780479553145], ["Q6UXN9", -0.4809780479553145], ["Q7L5D6", -0.4809780479553145], ["Q7Z3T8", -0.4809780479553145], ["Q8NFW8", -0.4809780479553145], ["Q8TD30", -0.4809780479553145], ["Q92785", -0.4809780479553145], ["Q96C23", -0.4809780479553145], ["Q96EP5", -0.4809780479553145], ["Q9BTC0", -0.4809780479553145], ["Q9BUI4", -0.4809780479553145], ["Q9BZE9", -0.4809780479553145], ["Q9H910", -0.4809780479553145], ["Q9HCM4", -0.4809780479553145], ["Q9NR09", -0.4809780479553145], ["Q9NTX5", -0.4809780479553145], ["Q9NUL3", -0.4809780479553145], ["Q9NZ32", -0.4809780479553145], ["Q9UFC0", -0.4809780479553145], ["Q9UHD8", -0.4809780479553145], ["Q9Y2Q3", -0.4809780479553145], ["Q9Y3B7", -0.4809780479553145], ["Q9Y3B9", -0.4809780479553145], ["Q9Y3C1", -0.4809780479553145], ["O14562", -0.5092252179873332], ["O43143", -0.5092252179873332], ["O43264", -0.5092252179873332], ["O60256", -0.5092252179873332], ["O75116", -0.5092252179873332], ["O75122", -0.5092252179873332], ["O75131", -0.5092252179873332], ["O75534", -0.5092252179873332], ["O76094", -0.5092252179873332], ["O94905", -0.5092252179873332], ["O95235", -0.5092252179873332], ["P05198", -0.5092252179873332], ["P08240", -0.5092252179873332], ["P20700", -0.5092252179873332], ["P26641", -0.5092252179873332], ["P49368", -0.5092252179873332], ["P49750", -0.5092252179873332], ["P50914", -0.5092252179873332], ["P52788", -0.5092252179873332], ["P53992", -0.5092252179873332], ["P60660", -0.5092252179873332], ["Q04837", -0.5092252179873332], ["Q13242", -0.5092252179873332], ["Q14807", -0.5092252179873332], ["Q15291", -0.5092252179873332], ["Q16762", -0.5092252179873332], ["Q5SW96", -0.5092252179873332], ["Q5W111", -0.5092252179873332], ["Q6KC79", -0.5092252179873332], ["Q7KZI7", -0.5092252179873332], ["Q92890", -0.5092252179873332], ["Q96BJ3", -0.5092252179873332], ["Q96BR5", -0.5092252179873332], ["Q96KM6", -0.5092252179873332], ["Q9H9A5", -0.5092252179873332], ["Q9NV31", -0.5092252179873332], ["Q9UI30", -0.5092252179873332], ["Q9UIG0", -0.5092252179873332], ["Q9UN86", -0.5092252179873332], ["Q9UNM6", -0.5092252179873332], ["Q9Y3D8", -0.5092252179873332], ["Q9Y490", -0.5092252179873332], ["O00159", -0.5377405503528547], ["O00161", -0.5377405503528547], ["O00232", -0.5377405503528547], ["O60869", -0.5377405503528547], ["O60870", -0.5377405503528547], ["O75717", -0.5377405503528547], ["O95299", -0.5377405503528547], ["P05556", -0.5377405503528547], ["P08754", -0.5377405503528547], ["P09001", -0.5377405503528547], ["P11142", -0.5377405503528547], ["P17174", -0.5377405503528547], ["P19338", -0.5377405503528547], ["P19623", -0.5377405503528547], ["P29144", -0.5377405503528547], ["P36957", -0.5377405503528547], ["P49407", -0.5377405503528547], ["P49756", -0.5377405503528547], ["Q13595", -0.5377405503528547], ["Q13823", -0.5377405503528547], ["Q14247", -0.5377405503528547], ["Q14318", -0.5377405503528547], ["Q14781", -0.5377405503528547], ["Q16822", -0.5377405503528547], ["Q1KMD3", -0.5377405503528547], ["Q3MHD2", -0.5377405503528547], ["Q53H96", -0.5377405503528547], ["Q86TV6", -0.5377405503528547], ["Q8IZD4", -0.5377405503528547], ["Q8N5K1", -0.5377405503528547], ["Q8NB90", -0.5377405503528547], ["Q8NI36", -0.5377405503528547], ["Q8TEQ6", -0.5377405503528547], ["Q8WVM0", -0.5377405503528547], ["Q92922", -0.5377405503528547], ["Q96DV4", -0.5377405503528547], ["Q96KR1", -0.5377405503528547], ["Q99996", -0.5377405503528547], ["Q9BQG0", -0.5377405503528547], ["Q9BTD8", -0.5377405503528547], ["Q9BVP2", -0.5377405503528547], ["Q9C0B1", -0.5377405503528547], ["Q9C0I1", -0.5377405503528547], ["Q9H9P8", -0.5377405503528547], ["Q9NQ29", -0.5377405503528547], ["Q9NQX3", -0.5377405503528547], ["Q9NXH9", -0.5377405503528547], ["Q9Y2K7", -0.5377405503528547], ["Q9Y606", -0.5377405503528547], ["O14818", -0.5665281275626076], ["O15294", -0.5665281275626076], ["O43660", -0.5665281275626076], ["O43823", -0.5665281275626076], ["O94788", -0.5665281275626076], ["O95707", -0.5665281275626076], ["O95757", -0.5665281275626076], ["P06748", -0.5665281275626076], ["P14324", -0.5665281275626076], ["P17655", -0.5665281275626076], ["P23919", -0.5665281275626076], ["P24666", -0.5665281275626076], ["P35659", -0.5665281275626076], ["P36405", -0.5665281275626076], ["P38919", -0.5665281275626076], ["P45877", -0.5665281275626076], ["P56589", -0.5665281275626076], ["P61981", -0.5665281275626076], ["Q01081", -0.5665281275626076], ["Q03154", -0.5665281275626076], ["Q04760", -0.5665281275626076], ["Q13428", -0.5665281275626076], ["Q14444", -0.5665281275626076], ["Q16718", -0.5665281275626076], ["Q16799", -0.5665281275626076], ["Q5RKV6", -0.5665281275626076], ["Q5W0B1", -0.5665281275626076], ["Q6UB35", -0.5665281275626076], ["Q8IZL8", -0.5665281275626076], ["Q8WXA9", -0.5665281275626076], ["Q92696", -0.5665281275626076], ["Q92878", -0.5665281275626076], ["Q92947", -0.5665281275626076], ["Q96FX7", -0.5665281275626076], ["Q96PV6", -0.5665281275626076], ["Q96RS6", -0.5665281275626076], ["Q96S44", -0.5665281275626076], ["Q96SB4", -0.5665281275626076], ["Q96T58", -0.5665281275626076], ["Q99956", -0.5665281275626076], ["Q9BV38", -0.5665281275626076], ["Q9BXY0", -0.5665281275626076], ["Q9BY44", -0.5665281275626076], ["Q9BZI7", -0.5665281275626076], ["Q9H9A6", -0.5665281275626076], ["Q9NRX2", -0.5665281275626076], ["Q9UBS4", -0.5665281275626076], ["Q9ULE6", -0.5665281275626076], ["Q9UMS4", -0.5665281275626076], ["Q9UNI6", -0.5665281275626076], ["Q9Y696", -0.5665281275626076], ["O15047", -0.5955921179420027], ["O15160", -0.5955921179420027], ["O43488", -0.5955921179420027], ["O94979", -0.5955921179420027], ["P04080", -0.5955921179420027], ["P05026", -0.5955921179420027], ["P06753", -0.5955921179420027], ["P07737", -0.5955921179420027], ["P14625", -0.5955921179420027], ["P20839", -0.5955921179420027], ["P27694", -0.5955921179420027], ["P40222", -0.5955921179420027], ["P46087", -0.5955921179420027], ["P61604", -0.5955921179420027], ["P62195", -0.5955921179420027], ["P62913", -0.5955921179420027], ["P63208", -0.5955921179420027], ["P63241", -0.5955921179420027], ["Q01518", -0.5955921179420027], ["Q04917", -0.5955921179420027], ["Q13309", -0.5955921179420027], ["Q13838", -0.5955921179420027], ["Q14684", -0.5955921179420027], ["Q15185", -0.5955921179420027], ["Q15269", -0.5955921179420027], ["Q15631", -0.5955921179420027], ["Q16630", -0.5955921179420027], ["Q16658", -0.5955921179420027], ["Q5T160", -0.5955921179420027], ["Q6W2J9", -0.5955921179420027], ["Q7Z2T5", -0.5955921179420027], ["Q7Z3K3", -0.5955921179420027], ["Q86T24", -0.5955921179420027], ["Q86U42", -0.5955921179420027], ["Q86YP4", -0.5955921179420027], ["Q92615", -0.5955921179420027], ["Q969U7", -0.5955921179420027], ["Q99460", -0.5955921179420027], ["Q9BQ52", -0.5955921179420027], ["Q9BYG3", -0.5955921179420027], ["Q9GZP4", -0.5955921179420027], ["Q9H0S4", -0.5955921179420027], ["Q9H7L9", -0.5955921179420027], ["Q9NZL9", -0.5955921179420027], ["Q9P016", -0.5955921179420027], ["Q9UBB6", -0.5955921179420027], ["Q9UNN5", -0.5955921179420027], ["Q9UPP1", -0.5955921179420027], ["Q9Y2R5", -0.5955921179420027], ["Q9Y697", -0.5955921179420027], ["O00567", -0.6249367779380635], ["O15382", -0.6249367779380635], ["O95292", -0.6249367779380635], ["O95396", -0.6249367779380635], ["P07910", -0.6249367779380635], ["P13667", -0.6249367779380635], ["P13995", -0.6249367779380635], ["P18754", -0.6249367779380635], ["P27144", -0.6249367779380635], ["P46459", -0.6249367779380635], ["P53618", -0.6249367779380635], ["P61160", -0.6249367779380635], ["P78347", -0.6249367779380635], ["Q02487", -0.6249367779380635], ["Q05048", -0.6249367779380635], ["Q08211", -0.6249367779380635], ["Q13435", -0.6249367779380635], ["Q13637", -0.6249367779380635], ["Q15050", -0.6249367779380635], ["Q15477", -0.6249367779380635], ["Q5SSJ5", -0.6249367779380635], ["Q5T6F2", -0.6249367779380635], ["Q69YH5", -0.6249367779380635], ["Q6NVY1", -0.6249367779380635], ["Q6PL18", -0.6249367779380635], ["Q8IWA0", -0.6249367779380635], ["Q8WZA9", -0.6249367779380635], ["Q96QR8", -0.6249367779380635], ["Q9BRA2", -0.6249367779380635], ["Q9BTT0", -0.6249367779380635], ["Q9BYD2", -0.6249367779380635], ["Q9H0R6", -0.6249367779380635], ["Q9H8M7", -0.6249367779380635], ["Q9HAW4", -0.6249367779380635], ["Q9NQT4", -0.6249367779380635], ["Q9NZL4", -0.6249367779380635], ["Q9UBC2", -0.6249367779380635], ["O00401", -0.6545664545020534], ["O43175", -0.6545664545020534], ["O75608", -0.6545664545020534], ["O75794", -0.6545664545020534], ["P04899", -0.6545664545020534], ["P07741", -0.6545664545020534], ["P08559", -0.6545664545020534], ["P10768", -0.6545664545020534], ["P22102", -0.6545664545020534], ["P24928", -0.6545664545020534], ["P30046", -0.6545664545020534], ["P31939", -0.6545664545020534], ["P34932", -0.6545664545020534], ["P37198", -0.6545664545020534], ["P45973", -0.6545664545020534], ["P50395", -0.6545664545020534], ["P54920", -0.6545664545020534], ["P55265", -0.6545664545020534], ["Q10570", -0.6545664545020534], ["Q12904", -0.6545664545020534], ["Q12955", -0.6545664545020534], ["Q13427", -0.6545664545020534], ["Q14019", -0.6545664545020534], ["Q49A26", -0.6545664545020534], ["Q5T447", -0.6545664545020534], ["Q5TC12", -0.6545664545020534], ["Q76FK4", -0.6545664545020534], ["Q7KZF4", -0.6545664545020534], ["Q8WU90", -0.6545664545020534], ["Q96EK7", -0.6545664545020534], ["Q96EY4", -0.6545664545020534], ["Q96KQ7", -0.6545664545020534], ["Q96T51", -0.6545664545020534], ["Q99829", -0.6545664545020534], ["Q9BXP5", -0.6545664545020534], ["Q9GZS1", -0.6545664545020534], ["Q9NV06", -0.6545664545020534], ["Q9NW13", -0.6545664545020534], ["Q9NY12", -0.6545664545020534], ["Q9UI36", -0.6545664545020534], ["Q9UKJ3", -0.6545664545020534], ["Q9Y520", -0.6545664545020534], ["A0AVT1", -0.6844855875507391], ["O75694", -0.6844855875507391], ["P00492", -0.6844855875507391], ["P04406", -0.6844855875507391], ["P07954", -0.6844855875507391], ["P18669", -0.6844855875507391], ["P38432", -0.6844855875507391], ["P42771", -0.6844855875507391], ["P52815", -0.6844855875507391], ["P62269", -0.6844855875507391], ["P84090", -0.6844855875507391], ["Q02040", -0.6844855875507391], ["Q08170", -0.6844855875507391], ["Q13042", -0.6844855875507391], ["Q14651", -0.6844855875507391], ["Q14694", -0.6844855875507391], ["Q15369", -0.6844855875507391], ["Q4G0J3", -0.6844855875507391], ["Q69YN4", -0.6844855875507391], ["Q7Z4H3", -0.6844855875507391], ["Q8NBS9", -0.6844855875507391], ["Q8TCS8", -0.6844855875507391], ["Q92747", -0.6844855875507391], ["Q92879", -0.6844855875507391], ["Q96EX3", -0.6844855875507391], ["Q99614", -0.6844855875507391], ["Q99986", -0.6844855875507391], ["Q9BVJ6", -0.6844855875507391], ["Q9NZB8", -0.6844855875507391], ["Q9Y2X9", -0.6844855875507391], ["Q9Y399", -0.6844855875507391], ["O00186", -0.7146987125093559], ["O00469", -0.7146987125093559], ["P21953", -0.7146987125093559], ["P22570", -0.7146987125093559], ["P25398", -0.7146987125093559], ["P30041", -0.7146987125093559], ["P31040", -0.7146987125093559], ["P31150", -0.7146987125093559], ["P36871", -0.7146987125093559], ["P48637", -0.7146987125093559], ["P50336", -0.7146987125093559], ["P52306", -0.7146987125093559], ["P55084", -0.7146987125093559], ["P62333", -0.7146987125093559], ["Q13155", -0.7146987125093559], ["Q13247", -0.7146987125093559], ["Q14679", -0.7146987125093559], ["Q6P2E9", -0.7146987125093559], ["Q6UX04", -0.7146987125093559], ["Q6WCQ1", -0.7146987125093559], ["Q8WW59", -0.7146987125093559], ["Q92783", -0.7146987125093559], ["Q96IU4", -0.7146987125093559], ["Q96IY1", -0.7146987125093559], ["Q99426", -0.7146987125093559], ["Q9BQ67", -0.7146987125093559], ["Q9BRX2", -0.7146987125093559], ["Q9NXG2", -0.7146987125093559], ["Q9NZZ3", -0.7146987125093559], ["Q9UGV2", -0.7146987125093559], ["Q9Y6W5", -0.7146987125093559], ["O14579", -0.7452104629394918], ["O43426", -0.7452104629394918], ["O60684", -0.7452104629394918], ["O75475", -0.7452104629394918], ["P21283", -0.7452104629394918], ["P22307", -0.7452104629394918], ["P41250", -0.7452104629394918], ["P46109", -0.7452104629394918], ["P49588", -0.7452104629394918], ["P49720", -0.7452104629394918], ["P56192", -0.7452104629394918], ["P61247", -0.7452104629394918], ["P62312", -0.7452104629394918], ["Q09666", -0.7452104629394918], ["Q0VDF9", -0.7452104629394918], ["Q15046", -0.7452104629394918], ["Q15428", -0.7452104629394918], ["Q4V328", -0.7452104629394918], ["Q6L8Q7", -0.7452104629394918], ["Q6WKZ4", -0.7452104629394918], ["Q8IY37", -0.7452104629394918], ["Q8N8S7", -0.7452104629394918], ["Q8NAV1", -0.7452104629394918], ["Q8WWM7", -0.7452104629394918], ["Q8WX93", -0.7452104629394918], ["Q9BVS4", -0.7452104629394918], ["Q9H6F5", -0.7452104629394918], ["Q9NPI1", -0.7452104629394918], ["Q9NXU5", -0.7452104629394918], ["Q9UKX7", -0.7452104629394918], ["Q9UQ80", -0.7452104629394918], ["Q9Y2B0", -0.7452104629394918], ["Q9Y3Y2", -0.7452104629394918], ["Q9Y5K5", -0.7452104629394918], ["O00425", -0.7760255732552376], ["O15355", -0.7760255732552376], ["O75947", -0.7760255732552376], ["P00491", -0.7760255732552376], ["P05091", -0.7760255732552376], ["P08865", -0.7760255732552376], ["P10155", -0.7760255732552376], ["P12004", -0.7760255732552376], ["P13639", -0.7760255732552376], ["P14866", -0.7760255732552376], ["P18887", -0.7760255732552376], ["P25786", -0.7760255732552376], ["P26639", -0.7760255732552376], ["P31949", -0.7760255732552376], ["P37108", -0.7760255732552376], ["P46821", -0.7760255732552376], ["P48506", -0.7760255732552376], ["P55081", -0.7760255732552376], ["P62888", -0.7760255732552376], ["P82650", -0.7760255732552376], ["Q13492", -0.7760255732552376], ["Q13601", -0.7760255732552376], ["Q13642", -0.7760255732552376], ["Q13685", -0.7760255732552376], ["Q14974", -0.7760255732552376], ["Q16531", -0.7760255732552376], ["Q6P587", -0.7760255732552376], ["Q8IYB3", -0.7760255732552376], ["Q8NFD5", -0.7760255732552376], ["Q8NFG4", -0.7760255732552376], ["Q92769", -0.7760255732552376], ["Q96C36", -0.7760255732552376], ["Q96CT7", -0.7760255732552376], ["Q9H6T3", -0.7760255732552376], ["Q9NQZ2", -0.7760255732552376], ["Q9NW08", -0.7760255732552376], ["Q9UNF1", -0.7760255732552376], ["Q9UNX4", -0.7760255732552376], ["Q9Y3D9", -0.7760255732552376], ["Q9Y3F4", -0.7760255732552376], ["O00233", -0.8071488815311059], ["O15514", -0.8071488815311059], ["O60293", -0.8071488815311059], ["P09132", -0.8071488815311059], ["P11388", -0.8071488815311059], ["P12277", -0.8071488815311059], ["P12955", -0.8071488815311059], ["P17844", -0.8071488815311059], ["P19387", -0.8071488815311059], ["P30101", -0.8071488815311059], ["P49903", -0.8071488815311059], ["P50747", -0.8071488815311059], ["P52294", -0.8071488815311059], ["P53041", -0.8071488815311059], ["P62304", -0.8071488815311059], ["Q00796", -0.8071488815311059], ["Q05519", -0.8071488815311059], ["Q15031", -0.8071488815311059], ["Q8N1G4", -0.8071488815311059], ["Q96G46", -0.8071488815311059], ["Q99439", -0.8071488815311059], ["Q9GZL7", -0.8071488815311059], ["Q9NUQ3", -0.8071488815311059], ["Q9UBW7", -0.8071488815311059], ["A4D1E9", -0.8385853324054076], ["O94888", -0.8385853324054076], ["O95140", -0.8385853324054076], ["P08133", -0.8385853324054076], ["P09234", -0.8385853324054076], ["P30085", -0.8385853324054076], ["P30086", -0.8385853324054076], ["P31946", -0.8385853324054076], ["P41252", -0.8385853324054076], ["P42574", -0.8385853324054076], ["P49591", -0.8385853324054076], ["P51608", -0.8385853324054076], ["P52209", -0.8385853324054076], ["P53602", -0.8385853324054076], ["P63010", -0.8385853324054076], ["Q08378", -0.8385853324054076], ["Q13347", -0.8385853324054076], ["Q13405", -0.8385853324054076], ["Q3KQU3", -0.8385853324054076], ["Q5UIP0", -0.8385853324054076], ["Q5VT52", -0.8385853324054076], ["Q6P1J9", -0.8385853324054076], ["Q86W42", -0.8385853324054076], ["Q86W56", -0.8385853324054076], ["Q8N9T8", -0.8385853324054076], ["Q92522", -0.8385853324054076], ["Q96FJ2", -0.8385853324054076], ["Q9BPU6", -0.8385853324054076], ["Q9GZR2", -0.8385853324054076], ["Q9UNE7", -0.8385853324054076], ["O15381", -0.8703399800828923], ["O94973", -0.8703399800828923], ["O96019", -0.8703399800828923], ["P14927", -0.8703399800828923], ["P33316", -0.8703399800828923], ["P40925", -0.8703399800828923], ["P46063", -0.8703399800828923], ["P53597", -0.8703399800828923], ["P60981", -0.8703399800828923], ["P61758", -0.8703399800828923], ["P62249", -0.8703399800828923], ["P78346", -0.8703399800828923], ["Q08209", -0.8703399800828923], ["Q14980", -0.8703399800828923], ["Q8N668", -0.8703399800828923], ["Q92841", -0.8703399800828923], ["Q99496", -0.8703399800828923], ["Q99661", -0.8703399800828923], ["Q9BPX3", -0.8703399800828923], ["Q9BV44", -0.8703399800828923], ["Q9NR45", -0.8703399800828923], ["Q9UBQ5", -0.8703399800828923], ["Q9Y4Z0", -0.8703399800828923], ["O43482", -0.902417991440706], ["O75152", -0.902417991440706], ["O75439", -0.902417991440706], ["P07195", -0.902417991440706], ["P09012", -0.902417991440706], ["P09417", -0.902417991440706], ["P11586", -0.902417991440706], ["P14550", -0.902417991440706], ["P19367", -0.902417991440706], ["P49916", -0.902417991440706], ["P56182", -0.902417991440706], ["P61964", -0.902417991440706], ["P62280", -0.902417991440706], ["Q15029", -0.902417991440706], ["Q7RTV0", -0.902417991440706], ["Q8N983", -0.902417991440706], ["Q8WUW1", -0.902417991440706], ["Q8WWH5", -0.902417991440706], ["Q8WX92", -0.902417991440706], ["Q96T88", -0.902417991440706], ["Q9BQC3", -0.902417991440706], ["Q9H307", -0.902417991440706], ["Q9NRK6", -0.902417991440706], ["Q9NVG8", -0.902417991440706], ["Q9Y265", -0.902417991440706], ["O94925", -0.934824649241834], ["P23381", -0.934824649241834], ["P23921", -0.934824649241834], ["P26440", -0.934824649241834], ["P28838", -0.934824649241834], ["P30307", -0.934824649241834], ["P34949", -0.934824649241834], ["P35250", -0.934824649241834], ["P39019", -0.934824649241834], ["P39748", -0.934824649241834], ["P49411", -0.934824649241834], ["P54819", -0.934824649241834], ["P61970", -0.934824649241834], ["P68402", -0.934824649241834], ["Q01581", -0.934824649241834], ["Q14676", -0.934824649241834], ["Q14978", -0.934824649241834], ["Q66PJ3", -0.934824649241834], ["Q6FI81", -0.934824649241834], ["Q7Z2Z2", -0.934824649241834], ["Q8IWX8", -0.934824649241834], ["Q8N4Q1", -0.934824649241834], ["Q8N806", -0.934824649241834], ["Q8WXI9", -0.934824649241834], ["Q96JM3", -0.934824649241834], ["Q9NP81", -0.934824649241834], ["Q9NS86", -0.934824649241834], ["Q9NWV8", -0.934824649241834], ["O00442", -0.9675653554604676], ["P06132", -0.9675653554604676], ["P11172", -0.9675653554604676], ["P15121", -0.9675653554604676], ["P29401", -0.9675653554604676], ["P46060", -0.9675653554604676], ["P46199", -0.9675653554604676], ["P50995", -0.9675653554604676], ["P51610", -0.9675653554604676], ["P60842", -0.9675653554604676], ["P68036", -0.9675653554604676], ["Q02880", -0.9675653554604676], ["Q09161", -0.9675653554604676], ["Q14376", -0.9675653554604676], ["Q14BN4", -0.9675653554604676], ["Q15417", -0.9675653554604676], ["Q8N335", -0.9675653554604676], ["Q92598", -0.9675653554604676], ["Q9H974", -0.9675653554604676], ["Q9P2S5", -0.9675653554604676], ["Q9UQR0", -0.9675653554604676], ["Q9Y232", -0.9675653554604676], ["Q9Y2Z0", -0.9675653554604676], ["O15371", -1.00064563472387], ["P16104", -1.00064563472387], ["P38606", -1.00064563472387], ["P47755", -1.00064563472387], ["P48643", -1.00064563472387], ["P49840", -1.00064563472387], ["Q00059", -1.00064563472387], ["Q05639", -1.00064563472387], ["Q12872", -1.00064563472387], ["Q13148", -1.00064563472387], ["Q13243", -1.00064563472387], ["Q14914", -1.00064563472387], ["Q15126", -1.00064563472387], ["Q15750", -1.00064563472387], ["Q6P4R8", -1.00064563472387], ["Q6UN15", -1.00064563472387], ["Q6ZRS2", -1.00064563472387], ["Q8WYP5", -1.00064563472387], ["Q96J01", -1.00064563472387], ["Q99816", -1.00064563472387], ["Q99873", -1.00064563472387], ["Q9BY42", -1.00064563472387], ["Q9UET6", -1.00064563472387], ["Q9Y3C8", -1.00064563472387], ["O15226", -1.034071137875609], ["O75083", -1.034071137875609], ["O75531", -1.034071137875609], ["O95376", -1.034071137875609], ["O95816", -1.034071137875609], ["P15289", -1.034071137875609], ["P27361", -1.034071137875609], ["P28066", -1.034071137875609], ["P30405", -1.034071137875609], ["P48163", -1.034071137875609], ["Q06265", -1.034071137875609], ["Q12888", -1.034071137875609], ["Q13442", -1.034071137875609], ["Q16643", -1.034071137875609], ["Q6YP21", -1.034071137875609], ["Q9BRK4", -1.034071137875609], ["Q9H074", -1.034071137875609], ["Q9H9Q2", -1.034071137875609], ["Q9Y624", -1.034071137875609], ["O15144", -1.0678476456651755], ["O43148", -1.0678476456651755], ["O95817", -1.0678476456651755], ["P25788", -1.0678476456651755], ["P32969", -1.0678476456651755], ["P49005", -1.0678476456651755], ["P51570", -1.0678476456651755], ["P78540", -1.0678476456651755], ["Q13907", -1.0678476456651755], ["Q15393", -1.0678476456651755], ["Q15910", -1.0678476456651755], ["Q68E01", -1.0678476456651755], ["Q9H3P2", -1.0678476456651755], ["Q9H9J2", -1.0678476456651755], ["Q9HA77", -1.0678476456651755], ["Q9NRV9", -1.0678476456651755], ["Q9UBE0", -1.0678476456651755], ["Q9UJ70", -1.0678476456651755], ["Q9UJU6", -1.0678476456651755], ["Q9Y6A5", -1.0678476456651755], ["A6NDG6", -1.101981072569348], ["O43324", -1.101981072569348], ["O75521", -1.101981072569348], ["O75940", -1.101981072569348], ["P00568", -1.101981072569348], ["P11047", -1.101981072569348], ["P22314", -1.101981072569348], ["P23284", -1.101981072569348], ["P27348", -1.101981072569348], ["P30038", -1.101981072569348], ["P40227", -1.101981072569348], ["P48147", -1.101981072569348], ["P62487", -1.101981072569348], ["Q14160", -1.101981072569348], ["Q52LJ0", -1.101981072569348], ["Q5QJE6", -1.101981072569348], ["Q6ZN17", -1.101981072569348], ["Q7L1Q6", -1.101981072569348], ["Q9NQW7", -1.101981072569348], ["Q9NSE4", -1.101981072569348], ["Q9P2R7", -1.101981072569348], ["Q9UKV3", -1.101981072569348], ["Q9UNP9", -1.101981072569348], ["Q9Y5J1", -1.101981072569348], ["A0MZ66", -1.1364774707508174], ["O00148", -1.1364774707508174], ["O43447", -1.1364774707508174], ["O60547", -1.1364774707508174], ["O94822", -1.1364774707508174], ["P07305", -1.1364774707508174], ["P17096", -1.1364774707508174], ["P21333", -1.1364774707508174], ["Q86SX6", -1.1364774707508174], ["Q8NI27", -1.1364774707508174], ["Q92597", -1.1364774707508174], ["Q96T23", -1.1364774707508174], ["Q9H1B7", -1.1364774707508174], ["Q9NWV4", -1.1364774707508174], ["Q9Y3I0", -1.1364774707508174], ["O00299", -1.1713430341599453], ["O43159", -1.1713430341599453], ["P32119", -1.1713430341599453], ["P43686", -1.1713430341599453], ["P50990", -1.1713430341599453], ["P55072", -1.1713430341599453], ["Q13111", -1.1713430341599453], ["Q13228", -1.1713430341599453], ["Q53T59", -1.1713430341599453], ["Q6ZWJ1", -1.1713430341599453], ["Q8TD19", -1.1713430341599453], ["Q92506", -1.1713430341599453], ["Q9BTT6", -1.1713430341599453], ["Q9H501", -1.1713430341599453], ["Q9UBV8", -1.1713430341599453], ["Q9UKG9", -1.1713430341599453], ["Q9UQ35", -1.1713430341599453], ["O75369", -1.2065841027857491], ["P04183", -1.2065841027857491], ["P24534", -1.2065841027857491], ["P31937", -1.2065841027857491], ["P35249", -1.2065841027857491], ["P45954", -1.2065841027857491], ["P54578", -1.2065841027857491], ["Q8WWK9", -1.2065841027857491], ["Q9BR76", -1.2065841027857491], ["Q9BSD7", -1.2065841027857491], ["Q9NVU0", -1.2065841027857491], ["Q9Y2H6", -1.2065841027857491], ["O43583", -1.2422071670625843], ["O75175", -1.2422071670625843], ["P00558", -1.2422071670625843], ["P09525", -1.2422071670625843], ["P10515", -1.2422071670625843], ["P30050", -1.2422071670625843], ["P34897", -1.2422071670625843], ["P42765", -1.2422071670625843], ["P60891", -1.2422071670625843], ["P78406", -1.2422071670625843], ["Q12905", -1.2422071670625843], ["Q15102", -1.2422071670625843], ["Q15366", -1.2422071670625843], ["Q86U28", -1.2422071670625843], ["Q86YS7", -1.2422071670625843], ["Q99714", -1.2422071670625843], ["Q99798", -1.2422071670625843], ["Q9HAD4", -1.2422071670625843], ["Q9Y221", -1.2422071670625843], ["O15305", -1.2782188724392092], ["O75367", -1.2782188724392092], ["O94903", -1.2782188724392092], ["O95983", -1.2782188724392092], ["P12268", -1.2782188724392092], ["P29353", -1.2782188724392092], ["P38398", -1.2782188724392092], ["P43897", -1.2782188724392092], ["P46777", -1.2782188724392092], ["Q86UK7", -1.2782188724392092], ["Q8IU81", -1.2782188724392092], ["Q9BVL2", -1.2782188724392092], ["Q9H9B1", -1.2782188724392092], ["Q9HD42", -1.2782188724392092], ["Q9Y333", -1.2782188724392092], ["Q9Y3C6", -1.2782188724392092], ["P16402", -1.314626024117389], ["P30048", -1.314626024117389], ["P51649", -1.314626024117389], ["P56537", -1.314626024117389], ["P61081", -1.314626024117389], ["P62330", -1.314626024117389], ["P82673", -1.314626024117389], ["Q6ZSJ8", -1.314626024117389], ["Q86V81", -1.314626024117389], ["Q96I99", -1.314626024117389], ["Q9NX58", -1.314626024117389], ["Q9ULV4", -1.314626024117389], ["O43684", -1.3514355919674153], ["P00338", -1.3514355919674153], ["P27816", -1.3514355919674153], ["P30626", -1.3514355919674153], ["Q12765", -1.3514355919674153], ["Q12824", -1.3514355919674153], ["Q15424", -1.3514355919674153], ["Q8NC51", -1.3514355919674153], ["Q9H8H0", -1.3514355919674153], ["Q9NQW6", -1.3514355919674153], ["Q9NR56", -1.3514355919674153], ["Q9UGI8", -1.3514355919674153], ["Q9UMY1", -1.3514355919674153], ["O95182", -1.3886547156284181], ["O95865", -1.3886547156284181], ["P11310", -1.3886547156284181], ["P23526", -1.3886547156284181], ["P23588", -1.3886547156284181], ["P50213", -1.3886547156284181], ["P60468", -1.3886547156284181], ["P62805", -1.3886547156284181], ["Q6NZY4", -1.3886547156284181], ["Q9H3P7", -1.3886547156284181], ["Q9Y224", -1.3886547156284181], ["O43716", -1.426290709801661], ["O43719", -1.426290709801661], ["O75390", -1.426290709801661], ["P04181", -1.426290709801661], ["P11766", -1.426290709801661], ["P20810", -1.426290709801661], ["P28331", -1.426290709801661], ["P63244", -1.426290709801661], ["Q96G03", -1.426290709801661], ["O43913", -1.4643510697454634], ["P05204", -1.4643510697454634], ["P51452", -1.4643510697454634], ["P80723", -1.4643510697454634], ["Q14195", -1.4643510697454634], ["Q7Z4W1", -1.4643510697454634], ["Q8WVJ2", -1.4643510697454634], ["Q96B26", -1.4643510697454634], ["Q96RT1", -1.4643510697454634], ["Q9UDY4", -1.4643510697454634], ["Q9UFG5", -1.4643510697454634], ["P00505", -1.5028434769808663], ["P10412", -1.5028434769808663], ["P22234", -1.5028434769808663], ["P27797", -1.5028434769808663], ["P48634", -1.5028434769808663], ["Q9BW83", -1.5028434769808663], ["Q9H2U2", -1.5028434769808663], ["Q9NQR4", -1.5028434769808663], ["P0CG08", -1.5417758052175927], ["P15170", -1.5417758052175927], ["P49848", -1.5417758052175927], ["P50579", -1.5417758052175927], ["P62136", -1.5417758052175927], ["Q6P1N9", -1.5417758052175927], ["Q99497", -1.5417758052175927], ["Q9Y2P8", -1.5417758052175927], ["P21266", -1.581156126510372], ["P35998", -1.581156126510372], ["P38117", -1.581156126510372], ["Q96HW7", -1.581156126510372], ["Q9Y314", -1.581156126510372], ["P06733", -1.6209927176562446], ["P13804", -1.6209927176562446], ["P60510", -1.6209927176562446], ["Q9NVH2", -1.6209927176562446], ["O15446", -1.661294066844009], ["P05114", -1.661294066844009], ["P12532", -1.661294066844009], ["P24752", -1.661294066844009], ["P34913", -1.661294066844009], ["P80404", -1.661294066844009], ["Q16555", -1.661294066844009], ["Q9ULU4", -1.661294066844009], ["O00273", -1.7020688805675812], ["O00422", -1.7020688805675812], ["P27695", -1.7020688805675812], ["P49454", -1.7020688805675812], ["Q15370", -1.7020688805675812], ["Q9NX24", -1.7020688805675812], ["O95861", -1.743326090815665], ["P25789", -1.743326090815665], ["P35914", -1.743326090815665], ["Q15007", -1.743326090815665], ["Q27J81", -1.743326090815665], ["O95059", -1.7850748625508288], ["P10809", -1.7850748625508288], ["P15531", -1.7850748625508288], ["P48047", -1.7850748625508288], ["Q9BY32", -1.7850748625508288], ["P09972", -1.8273246014917721], ["P63220", -1.8273246014917721], ["Q3YEC7", -1.8273246014917721], ["Q8NCW5", -1.8273246014917721], ["Q9UL25", -1.8273246014917721], ["Q9Y281", -1.8273246014917721], ["P05388", -1.8700849622133329], ["P62140", -1.8700849622133329], ["Q15397", -1.8700849622133329], ["Q9BVG9", -1.8700849622133329], ["P04075", -1.9133658565796359], ["P04179", -1.9133658565796359], ["Q96DI7", -1.9133658565796359], ["Q9Y6V7", -1.9133658565796359], ["P40926", -1.9571774625265654], ["Q15365", -1.9571774625265654], ["P19404", -2.0015302332107483], ["P23528", -2.0015302332107483], ["P49189", -2.0015302332107483], ["P49821", -2.0015302332107483], ["O76003", -2.0464349065431278], ["P30044", -2.0464349065431278], ["P38646", -2.0464349065431278], ["P51790", -2.0464349065431278], ["O15020", -2.1379443966160254], ["Q7L590", -2.1379443966160254], ["Q9Y617", -2.1379443966160254], ["Q9Y673", -2.1379443966160254], ["P13797", -2.1845722045277824], ["P55769", -2.1845722045277824], ["Q13426", -2.1845722045277824], ["O00763", -2.2317979195120636], ["P49006", -2.2317979195120636], ["P13489", -2.3280927000953655], ["P37802", -2.3280927000953655], ["Q02952", -2.47733884986653], ["Q15181", -2.47733884986653], ["Q96GD0", -2.47733884986653], ["Q9UIF9", -2.47733884986653], ["P62318", -2.528423470718114], ["P29966", -2.580200080183491], ["P60174", -2.580200080183491], ["Q01658", -2.6326837467103497], ["P30084", -2.6858899929091273], ["Q9BQA1", -2.7945346917076734], ["P05165", -2.850006622487808], ["Q14202", -2.850006622487808], ["Q99961", -2.906268128739118], ["P11498", -2.963337284449491], ["Q2NKX8", -2.963337284449491], ["P49419", -3.0799737279316677], ["P09110", -3.200072430029395], ["P16152", -3.2614718339663136], ["O94762", -3.323800219182941], ["Q9ULV3", -3.516589273664297], ["Q96RQ3", -3.5828675431855714], ["P36639", -5.736815772853109], ["Q13085", -6.149390655935942], ["Q9BV79", -7.779405564180754], ["Q9BV23", -14.388945867155861]]}, "terms": {"Sphingolipid metabolism": {"direction": "up", "overlap": {"value": 15, "mean": 11.00242718446602, "std": 4.192861933829232, "bin": {"bin_hit": 5, "bin_50": 1, "bin_100": 3, "bin_250": 12, "bin_500": 16}}, "setsize": {"value": 26, "mean": 26.135922330097088, "std": 2.1968580551223003, "bin": {"bin_hit": 62, "bin_50": 62, "bin_100": 62, "bin_250": 62, "bin_500": 62}}, "score": {"value": 3.856428309102701, "mean": 1.1708540815039898, "std": 2.1941615995620167, "bin": {"bin_hit": 7.993620414673046, "bin_50": 3.444672131147541, "bin_100": 5.373238180196253, "bin_250": 10.109617021276597, "bin_500": 6.995652173913044}}, "pval": {"value": 0.0001150558207214, "mean": 0.1757583754913391, "std": 0.2567064655985949, "bin": {"bin_hit": 0.0006485864754413, "bin_50": 0.2588687133858448, "bin_100": 0.0216384292134882, "bin_250": 2.30996546554735e-08, "bin_500": 2.6505537497549172e-08}}, "signature_idxs": {"edge": [191, 130, 99, 72, 293, 298, 11, 171, 234, 273, 116, 56, 122, 127, 159], "full": [617, 303, 1060, 619, 2496, 171, 122, 298, 293, 72, 726, 127, 2891, 11, 234, 1847, 130, 99, 116, 273, 56, 159, 2120, 707, 191, 2256]}}, "Slc mediated transmembrane transport": {"direction": "up", "overlap": {"value": 12, "mean": 8.672330097087379, "std": 4.348519601656105, "bin": {"bin_hit": 3, "bin_50": 0, "bin_100": 2, "bin_250": 7, "bin_500": 13}}, "setsize": {"value": 21, "mean": 21.910194174757283, "std": 3.146764860695784, "bin": {"bin_hit": 101, "bin_50": 101, "bin_100": 101, "bin_250": 101, "bin_500": 101}}, "score": {"value": 3.333161108373445, "mean": 1.4735742044813558, "std": 1.3934177975338422, "bin": {"bin_hit": 2.7285896501457727, "bin_50": 0.0, "bin_100": 2.1041666666666665, "bin_250": 3.057845744680851, "bin_500": 2.939864483342744}}, "pval": {"value": 0.0008586520567841, "mean": 0.239038892478899, "std": 0.3068823132077037, "bin": {"bin_hit": 0.1056736891610583, "bin_50": 1.0, "bin_100": 0.2533609509960167, "bin_250": 0.0112337149724148, "bin_500": 0.0011775943662494}}, "signature_idxs": {"edge": [256, 289, 321, 101, 169, 105, 50, 338, 54, 151, 217, 317], "full": [361, 727, 863, 338, 217, 3043, 317, 1659, 169, 636, 256, 899, 954, 50, 105, 101, 321, 289, 1599, 54, 151]}}, "Defects in vitamin and cofactor metabolism": {"direction": "dw", "overlap": {"value": 4, "mean": 4.699029126213592, "std": 1.380058753894271, "bin": {}}, "setsize": {"value": 10, "mean": 10.41747572815534, "std": 1.1149841902720006, "bin": {}}, "score": {"value": -3.195319675288702, "mean": -1.925850130170444, "std": 1.4215925503654463, "bin": {}}, "pval": {"value": 0.0013967603631268, "mean": 0.1382624821904612, "std": 0.2578001464511674, "bin": {}}, "signature_idxs": {"edge": [3178, 3188, 3181, 3190], "full": [3178, 1031, 3181, 1357, 2720, 3190, 1217, 3188, 679, 1388]}}, "Glycosaminoglycan metabolism": {"direction": "up", "overlap": {"value": 8, "mean": 6.563106796116505, "std": 2.387954817808654, "bin": {"bin_hit": 2, "bin_50": 1, "bin_100": 2, "bin_250": 5, "bin_500": 9}}, "setsize": {"value": 12, "mean": 14.388349514563108, "std": 2.3973407990867264, "bin": {"bin_hit": 70, "bin_50": 70, "bin_100": 70, "bin_250": 70, "bin_500": 70}}, "score": {"value": 3.186849391282702, "mean": 0.750167459040055, "std": 1.8682770414846892, "bin": {"bin_hit": 2.606194690265487, "bin_50": 3.042874396135266, "bin_100": 3.0729166666666665, "bin_250": 3.1417673235855053, "bin_500": 2.920220823374962}}, "pval": {"value": 0.0014383164982783, "mean": 0.1742505874253542, "std": 0.2409021330213527, "bin": {"bin_hit": 0.1867364476576967, "bin_50": 0.2870659866655126, "bin_100": 0.1454623761357323, "bin_250": 0.0270875919971298, "bin_500": 0.0065607705696853}}, "signature_idxs": {"edge": [291, 131, 101, 166, 293, 11, 82, 275], "full": [2031, 275, 293, 726, 310, 11, 166, 131, 82, 101, 291, 1696]}}, "Glycosphingolipid metabolism": {"direction": "up", "overlap": {"value": 10, "mean": 7.514563106796117, "std": 2.3948329397108954, "bin": {"bin_hit": 5, "bin_50": 1, "bin_100": 3, "bin_250": 8, "bin_500": 11}}, "setsize": {"value": 17, "mean": 15.521844660194176, "std": 1.2175929202976112, "bin": {"bin_hit": 33, "bin_50": 33, "bin_100": 33, "bin_250": 33, "bin_500": 33}}, "score": {"value": 3.160390156429067, "mean": 0.6340330218232789, "std": 2.2116324239586063, "bin": {"bin_hit": 16.319805194805195, "bin_50": 6.585286458333333, "bin_100": 10.597894736842106, "bin_250": 13.2873640167364, "bin_500": 9.977319587628866}}, "pval": {"value": 0.0015755800124779, "mean": 0.1371235236408302, "std": 0.2290247571497847, "bin": {"bin_hit": 3.085011016742901e-05, "bin_50": 0.1471951297158956, "bin_100": 0.0038117145357013, "bin_250": 8.706263055400972e-07, "bin_500": 2.3596719796488026e-07}}, "signature_idxs": {"edge": [72, 293, 11, 234, 273, 116, 56, 122, 127, 191], "full": [617, 619, 122, 298, 293, 72, 726, 127, 2891, 11, 234, 116, 273, 56, 2120, 707, 191]}}, "Biotin transport and metabolism": {"direction": "dw", "overlap": {"value": 5, "mean": 5.116504854368932, "std": 1.4145634399717075, "bin": {}}, "setsize": {"value": 8, "mean": 8.03640776699029, "std": 0.9533460280821764, "bin": {}}, "score": {"value": -2.99633310882418, "mean": -2.0531807267583235, "std": 1.4870488903095456, "bin": {}}, "pval": {"value": 0.0027324776319455, "mean": 0.1038341457369441, "std": 0.2349123521752051, "bin": {}}, "signature_idxs": {"edge": [3178, 3181, 3188, 3190, 3164], "full": [3164, 3178, 1031, 3181, 2720, 3190, 3188, 1388]}}, "Choline catabolism": {"direction": "dw", "overlap": {"value": 1, "mean": 0.9101941747572816, "std": 0.4613119336850514, "bin": {}}, "setsize": {"value": 1, "mean": 1.296116504854369, "std": 0.516414511406939, "bin": {}}, "score": {"value": -2.990997840913792, "mean": -1.6165996630332595, "std": 1.7944375627524491, "bin": {}}, "pval": {"value": 0.0027806745936032, "mean": 0.146782453012119, "std": 0.2300685534210116, "bin": {}}, "signature_idxs": {"edge": [3183], "full": [3183]}}, "Rrna modification in the nucleus and cytosol": {"direction": "dw", "overlap": {"value": 23, "mean": 28.45631067961165, "std": 9.286985045927665, "bin": {}}, "setsize": {"value": 53, "mean": 54.34466019417476, "std": 2.651734298048095, "bin": {}}, "score": {"value": -2.98215736456912, "mean": -1.5049432386646604, "std": 1.3675746480917093, "bin": {}}, "pval": {"value": 0.0028622483491889, "mean": 0.3185351385207093, "std": 0.3550565174366032, "bin": {}}, "signature_idxs": {"edge": [2690, 2669, 2337, 2338, 2600, 3099, 2485, 2468, 2375, 3122, 2456, 2631, 2519, 3146, 2655, 2494, 3162, 3048, 2567, 2569, 2948, 2703, 2706], "full": [2669, 1607, 2494, 1938, 987, 2033, 1886, 1843, 1448, 2456, 1452, 3162, 1508, 1326, 1074, 948, 1628, 2690, 1670, 1462, 2057, 2468, 573, 2519, 2655, 2375, 1300, 2249, 1474, 1525, 2600, 1870, 2485, 1432, 1872, 3048, 2703, 1309, 2567, 2337, 3122, 2631, 2569, 1529, 2338, 1487, 2706, 3099, 1936, 2219, 1350, 2948, 3146]}}, "Acetylcholine regulates insulin secretion": {"direction": "dw", "overlap": {"value": 1, "mean": 1.0, "std": 0.6848377146578521, "bin": {}}, "setsize": {"value": 1, "mean": 1.719676549865229, "std": 0.8255462313015116, "bin": {}}, "score": {"value": -2.9748403059232675, "mean": -0.8196527456401349, "std": 1.5532118962961947, "bin": {}}, "pval": {"value": 0.0029314110874398, "mean": 0.3287161998934058, "std": 0.3302672946353949, "bin": {}}, "signature_idxs": {"edge": [3173], "full": [3173]}}, "Rna polymerase ii transcription termination": {"direction": "dw", "overlap": {"value": 23, "mean": 17.20873786407767, "std": 7.0779379202652954, "bin": {}}, "setsize": {"value": 43, "mean": 44.70145631067961, "std": 3.184564992246008, "bin": {}}, "score": {"value": -2.9743452765319605, "mean": -0.86103981823213, "std": 1.0646102763598504, "bin": {}}, "pval": {"value": 0.002936144870707, "mean": 0.4512938122200936, "std": 0.3419500531624954, "bin": {}}, "signature_idxs": {"edge": [2407, 2411, 2958, 2549, 2950, 2477, 2723, 2725, 2851, 2585, 2755, 2880, 2877, 2465, 2619, 2872, 3036, 2667, 2508, 3172, 2436, 2787, 2696], "full": [2950, 2136, 1609, 2787, 1321, 1851, 2407, 2723, 3172, 1109, 2006, 2411, 2508, 2725, 1077, 2585, 2851, 2549, 1366, 2324, 2872, 2619, 1724, 2465, 2060, 422, 2877, 2477, 3036, 2755, 2696, 1213, 2958, 1176, 2019, 1968, 2880, 1526, 2436, 1875, 1392, 2667, 1647]}}, "Scavenging by class b receptors": {"direction": "up", "overlap": {"value": 0, "mean": 0.145679012345679, "std": 0.366514912271715, "bin": {"bin_hit": 1, "bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0419753086419754, "std": 0.2005327457209575, "bin": {"bin_hit": 2, "bin_50": 2, "bin_100": 2, "bin_250": 2, "bin_500": 2}}, "score": {"value": 2.957428494399593, "mean": 2.082821567211886, "std": 1.8633299667806096, "bin": {"bin_hit": 88.42105263157895, "bin_50": 211.375, "bin_100": 104.09278350515464, "bin_250": 40.4390243902439, "bin_500": 19.593939393939397}}, "pval": {"value": 0.0031021669081248, "mean": 0.0465602836219474, "std": 0.1224919585458108, "bin": {"bin_hit": 0.0224317453440025, "bin_50": 0.0095889857469295, "bin_100": 0.0191317754164375, "bin_250": 0.0478658316601909, "bin_500": 0.0949311108898137}}, "signature_idxs": {"edge": [], "full": [43]}}, "Intra golgi and retrograde golgi to er traffic": {"direction": "up", "overlap": {"value": 51, "mean": 23.762135922330096, "std": 8.961715947260837, "bin": {"bin_hit": 5, "bin_50": 5, "bin_100": 5, "bin_250": 11, "bin_500": 28}}, "setsize": {"value": 99, "mean": 91.83252427184466, "std": 10.213669235838784, "bin": {"bin_hit": 181, "bin_50": 181, "bin_100": 181, "bin_250": 181, "bin_500": 181}}, "score": {"value": 2.944350021039892, "mean": 0.7836914286379623, "std": 1.1120768516172963, "bin": {"bin_hit": 2.5581095041322315, "bin_50": 6.437887396694215, "bin_100": 3.0309139784946235, "bin_250": 2.6811814556331006, "bin_500": 3.733255125411988}}, "pval": {"value": 0.0032363375955049, "mean": 0.5449079285432085, "std": 0.4008074869702365, "bin": {"bin_hit": 0.0537894092688447, "bin_50": 0.0016900813978939, "bin_100": 0.0301417198148606, "bin_250": 0.0045446840158695, "bin_500": 4.603588714706151e-08}}, "signature_idxs": {"edge": [2, 633, 261, 394, 259, 639, 390, 398, 399, 404, 657, 531, 28, 29, 30, 778, 817, 36, 417, 420, 812, 814, 813, 798, 691, 577, 182, 444, 710, 568, 857, 320, 458, 833, 583, 596, 615, 737, 348, 612, 604, 354, 100, 103, 231, 362, 489, 500, 240, 242, 378], "full": [1352, 1233, 28, 2635, 798, 259, 604, 1101, 2304, 36, 398, 103, 1131, 1574, 240, 2312, 1535, 348, 399, 390, 568, 1169, 633, 2, 972, 990, 1897, 583, 2503, 2865, 1754, 1069, 417, 596, 2266, 261, 2504, 2267, 2547, 831, 657, 531, 1624, 320, 2824, 833, 458, 2152, 1511, 489, 778, 420, 354, 812, 691, 813, 612, 639, 1913, 2325, 814, 3004, 29, 362, 242, 737, 394, 817, 182, 500, 1679, 1048, 1118, 1214, 1215, 2759, 1347, 1927, 2780, 2168, 378, 404, 444, 2170, 1007, 1928, 961, 577, 1183, 880, 2295, 100, 1933, 615, 231, 30, 857, 710, 1162]}}, "Protein localization": {"direction": "up", "overlap": {"value": 34, "mean": 25.97087378640777, "std": 10.717199959161563, "bin": {"bin_hit": 9, "bin_50": 6, "bin_100": 9, "bin_250": 13, "bin_500": 26}}, "setsize": {"value": 73, "mean": 74.18203883495146, "std": 6.26233677332747, "bin": {"bin_hit": 142, "bin_50": 142, "bin_100": 142, "bin_250": 142, "bin_500": 142}}, "score": {"value": 2.9419204165558583, "mean": 1.5594110758345356, "std": 2.0947329132902324, "bin": {"bin_hit": 6.350688040856859, "bin_50": 10.271203830369355, "bin_100": 7.576666385063783, "bin_250": 4.229112833763996, "bin_500": 4.57050623624358}}, "pval": {"value": 0.0032618374267203, "mean": 0.2555609300308859, "std": 0.3569924888492793, "bin": {"bin_hit": 3.076170068188241e-05, "bin_50": 5.608080016760057e-05, "bin_100": 8.408639046500143e-06, "bin_250": 3.919880794337123e-05, "bin_500": 3.852921392107203e-09}}, "signature_idxs": {"edge": [0, 130, 3, 7, 266, 515, 16, 17, 277, 280, 527, 421, 428, 41, 414, 431, 51, 557, 429, 438, 61, 62, 322, 193, 332, 578, 338, 211, 217, 354, 628, 625, 497, 505], "full": [429, 1022, 966, 211, 578, 414, 619, 1747, 505, 0, 193, 3066, 1610, 2788, 2927, 527, 277, 1316, 651, 438, 1134, 752, 3184, 17, 3129, 338, 217, 1654, 7, 2640, 1997, 515, 3113, 3125, 3155, 973, 62, 266, 1507, 130, 1324, 2409, 3059, 2102, 497, 431, 354, 51, 421, 280, 557, 625, 2280, 41, 2832, 628, 1967, 3, 3009, 322, 2253, 61, 16, 698, 2256, 1697, 428, 2979, 1230, 2298, 332, 1703, 1272]}}, "Hydrolysis of lpc": {"direction": "up", "overlap": {"value": 0, "mean": 0.1913265306122449, "std": 0.3933455088038081, "bin": {"bin_hit": 1, "bin_50": 0, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_hit": 3, "bin_50": 3, "bin_100": 3, "bin_250": 3, "bin_500": 3}}, "score": {"value": 2.897608626481844, "mean": 1.606387230424858, "std": 2.1513169649816297, "bin": {"bin_hit": 44.20614035087719, "bin_50": 0.0, "bin_100": 52.04123711340206, "bin_250": 20.21747967479675, "bin_500": 9.795959595959596}}, "pval": {"value": 0.0037601949764813, "mean": 0.0721363350848721, "std": 0.1543226992102528, "bin": {"bin_hit": 0.0334598353267012, "bin_50": 1.0, "bin_100": 0.028561350265047, "bin_250": 0.0709359846499108, "bin_500": 0.1389682081054653}}, "signature_idxs": {"edge": [], "full": [80]}}, "Defective chst14 causes eds musculocontractural type": {"direction": "up", "overlap": {"value": 0, "mean": 0.1370262390670553, "std": 0.34387504834488, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_hit": 4, "bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 2.894366367039415, "mean": 1.9661432903616765, "std": 1.7638280687711525, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 34.69072164948454, "bin_250": 13.476964769647696, "bin_500": 6.52996632996633}}, "pval": {"value": 0.0037992458723126, "mean": 0.0755895511950136, "std": 0.1549979843407287, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 0.0379011901229756, "bin_250": 0.0934493577283265, "bin_500": 0.1808667432566313}}, "signature_idxs": {"edge": [], "full": [82]}}, "Dermatan sulfate biosynthesis": {"direction": "up", "overlap": {"value": 0, "mean": 0.163323782234957, "std": 0.3773324574128408, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0515759312320916, "std": 0.2211692893455921, "bin": {"bin_hit": 6, "bin_50": 6, "bin_100": 6, "bin_250": 6, "bin_500": 6}}, "score": {"value": 2.894366367039415, "mean": 1.8929413643006845, "std": 1.7870120130693752, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 20.81030927835052, "bin_250": 8.084552845528455, "bin_500": 3.917171717171717}}, "pval": {"value": 0.0037992458723126, "mean": 0.094908536871193, "std": 0.1876615326887714, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 0.0563150378970086, "bin_250": 0.1368589802283267, "bin_500": 0.2586577321272367}}, "signature_idxs": {"edge": [], "full": [82]}}, "Synthesis of epoxy eet and dihydroxyeicosatrienoic acids dhet": {"direction": "dw", "overlap": {"value": 1, "mean": 0.5447470817120622, "std": 0.4979936733315535, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -2.874139700458491, "mean": -0.3277131806520118, "std": 2.4641160378678264, "bin": {}}, "pval": {"value": 0.0040512972038242, "mean": 0.1066771380109132, "std": 0.2087100656559332, "bin": {}}, "signature_idxs": {"edge": [3113], "full": [3113]}}, "Biosynthesis of maresins": {"direction": "dw", "overlap": {"value": 1, "mean": 0.5447470817120622, "std": 0.4979936733315535, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -2.874139700458491, "mean": -0.3277131806520118, "std": 2.4641160378678264, "bin": {}}, "pval": {"value": 0.0040512972038242, "mean": 0.1066771380109132, "std": 0.2087100656559332, "bin": {}}, "signature_idxs": {"edge": [3113], "full": [3113]}}, "Trna aminoacylation": {"direction": "dw", "overlap": {"value": 23, "mean": 16.483009708737864, "std": 6.348855310777471, "bin": {}}, "setsize": {"value": 37, "mean": 35.58980582524272, "std": 1.9066039959172487, "bin": {}}, "score": {"value": -2.863749901329654, "mean": -0.9220603626179013, "std": 1.038233561860114, "bin": {}}, "pval": {"value": 0.0041865842495212, "mean": 0.449939178371201, "std": 0.3622549439462865, "bin": {}}, "signature_idxs": {"edge": [2926, 2836, 2812, 2472, 3090, 2681, 2726, 2186, 2246, 2243, 2618, 2228, 2743, 2741, 2650, 2919, 3169, 2641, 2643, 2645, 2268, 2944, 2550], "full": [2926, 1939, 2186, 2228, 2812, 2681, 1577, 2641, 2741, 1755, 2643, 1662, 1756, 2743, 2268, 1542, 2645, 2550, 2618, 2726, 2650, 3169, 2243, 1415, 1812, 2472, 2246, 1345, 742, 3090, 2919, 2836, 1223, 2944, 1013, 937, 1877]}}, "Transport of nucleotide sugars": {"direction": "up", "overlap": {"value": 0, "mean": 0.1941747572815534, "std": 0.3955640541255021, "bin": {"bin_hit": 1, "bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0145631067961165, "std": 0.1197957541675055, "bin": {"bin_hit": 4, "bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 2.863520185912165, "mean": 1.506134463478804, "std": 1.9432557538988255, "bin": {"bin_hit": 29.46783625730994, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 13.476964769647696, "bin_500": 6.52996632996633}}, "pval": {"value": 0.0041896211792857, "mean": 0.116432399816558, "std": 0.1948415235748172, "bin": {"bin_hit": 0.0443645855413871, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0934493577283265, "bin_500": 0.1808667432566313}}, "signature_idxs": {"edge": [], "full": [101]}}, "Zinc efflux and compartmentalization by the slc30 family": {"direction": "up", "overlap": {"value": 0, "mean": 0.3191489361702128, "std": 0.4751878902176554, "bin": {"bin_hit": 1, "bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.2042553191489362, "std": 0.403156401100494, "bin": {"bin_hit": 5, "bin_50": 5, "bin_100": 5, "bin_250": 5, "bin_500": 5}}, "score": {"value": 2.8570159499104317, "mean": 1.3875755066846402, "std": 1.9008983134839692, "bin": {"bin_hit": 22.098684210526315, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 10.106707317073171, "bin_500": 4.8969696969696965}}, "pval": {"value": 0.0042764434819333, "mean": 0.1397213072562257, "std": 0.2206522820416731, "bin": {"bin_hit": 0.0551473634714521, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1154193350298319, "bin_500": 0.2207303711304172}}, "signature_idxs": {"edge": [], "full": [105]}}, "Neurotoxicity of clostridium toxins": {"direction": "up", "overlap": {"value": 0, "mean": 0.2583732057416268, "std": 0.4377402109658441, "bin": {"bin_hit": 1, "bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_hit": 8, "bin_50": 8, "bin_100": 8, "bin_250": 8, "bin_500": 8}}, "score": {"value": 2.85213542304408, "mean": 1.251695468241205, "std": 2.25806897109107, "bin": {"bin_hit": 12.62406015037594, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 5.7735191637630665, "bin_500": 2.7974025974025976}}, "pval": {"value": 0.0043426595414699, "mean": 0.0890098072663544, "std": 0.1746954164622726, "bin": {"bin_hit": 0.0867773139397569, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1781979724676324, "bin_500": 0.3290745839784397}}, "signature_idxs": {"edge": [], "full": [108]}}, "Toxicity of botulinum toxin type d botd": {"direction": "up", "overlap": {"value": 0, "mean": 0.2583732057416268, "std": 0.4377402109658441, "bin": {"bin_hit": 1, "bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_hit": 3, "bin_50": 3, "bin_100": 3, "bin_250": 3, "bin_500": 3}}, "score": {"value": 2.85213542304408, "mean": 1.251695468241205, "std": 2.25806897109107, "bin": {"bin_hit": 44.20614035087719, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 20.21747967479675, "bin_500": 9.795959595959596}}, "pval": {"value": 0.0043426595414699, "mean": 0.0890098072663544, "std": 0.1746954164622726, "bin": {"bin_hit": 0.0334598353267012, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0709359846499108, "bin_500": 0.1389682081054653}}, "signature_idxs": {"edge": [], "full": [108]}}, "Abacavir transmembrane transport": {"direction": "up", "overlap": {"value": 0, "mean": 0.2246913580246913, "std": 0.4173789065749626, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_hit": 2, "bin_50": 2, "bin_100": 2, "bin_250": 2, "bin_500": 2}}, "score": {"value": 2.817915396131497, "mean": 1.372307789092464, "std": 2.217837220948615, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 40.4390243902439, "bin_500": 19.593939393939397}}, "pval": {"value": 0.0048336544546501, "mean": 0.0733970142334326, "std": 0.1515686774147872, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0478658316601909, "bin_500": 0.0949311108898137}}, "signature_idxs": {"edge": [], "full": [129]}}, "Hs gag biosynthesis": {"direction": "up", "overlap": {"value": 0, "mean": 0.4, "std": 0.57138996008548, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.4, "std": 0.5618502253053528, "bin": {"bin_hit": 17, "bin_50": 17, "bin_100": 17, "bin_250": 17, "bin_500": 17}}, "score": {"value": 2.814651209258048, "mean": 1.2336060557853104, "std": 1.725731850428788, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 2.523628048780488, "bin_500": 1.2227272727272729}}, "pval": {"value": 0.0048830199581935, "mean": 0.2094856479929745, "std": 0.2756692389329105, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.3411306657380243, "bin_500": 0.5719289219770226}}, "signature_idxs": {"edge": [], "full": [131]}}, "Defects in biotin btn metabolism": {"direction": "dw", "overlap": {"value": 4, "mean": 4.322815533980583, "std": 1.2148609872736351, "bin": {}}, "setsize": {"value": 7, "mean": 6.684466019417476, "std": 0.4647281868794612, "bin": {}}, "score": {"value": -2.80952250095425, "mean": -1.956139594978885, "std": 1.4379338792361345, "bin": {}}, "pval": {"value": 0.004961505081257, "mean": 0.1020422735751905, "std": 0.2253926888686752, "bin": {}}, "signature_idxs": {"edge": [3178, 3188, 3181, 3190], "full": [3178, 1031, 3181, 2720, 3190, 3188, 1388]}}, "Tnfr1 mediated ceramide production": {"direction": "dw", "overlap": {"value": 1, "mean": 0.720873786407767, "std": 0.4485696941144109, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -2.8004851020181896, "mean": -1.0208892096662905, "std": 1.827171007388144, "bin": {}}, "pval": {"value": 0.0051025862712679, "mean": 0.2297852023292357, "std": 0.2821514571367339, "bin": {}}, "signature_idxs": {"edge": [3071], "full": [3071]}}, "Metabolism of ingested semet sec mesec into h2se": {"direction": "dw", "overlap": {"value": 1, "mean": 0.9878640776699028, "std": 0.5765214577393092, "bin": {}}, "setsize": {"value": 1, "mean": 1.5072815533980584, "std": 0.5807973999225635, "bin": {}}, "score": {"value": -2.7955578926719618, "mean": -0.9818123235856022, "std": 1.484854477943523, "bin": {}}, "pval": {"value": 0.0051810221497694, "mean": 0.3716350600222675, "std": 0.3475831380990472, "bin": {}}, "signature_idxs": {"edge": [3056], "full": [3056]}}, "Bicarbonate transporters": {"direction": "up", "overlap": {"value": 0, "mean": 0.4613003095975232, "std": 0.5789556463705147, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.3746130030959751, "std": 0.4840228310807147, "bin": {"bin_hit": 4, "bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 2.7819603025088093, "mean": 0.8949671679778185, "std": 1.6187147700815585, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 13.476964769647696, "bin_500": 6.52996632996633}}, "pval": {"value": 0.0054031648717636, "mean": 0.2945438675971197, "std": 0.2999119980296623, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0934493577283265, "bin_500": 0.1808667432566313}}, "signature_idxs": {"edge": [], "full": [151]}}, "Sodium calcium exchangers": {"direction": "dw", "overlap": {"value": 1, "mean": 0.6286407766990292, "std": 0.4831682425100708, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -2.772536338989536, "mean": -0.5011899121923299, "std": 1.7645396006214291, "bin": {}}, "pval": {"value": 0.0055621308817985, "mean": 0.2612889577560998, "std": 0.271510210139216, "bin": {}}, "signature_idxs": {"edge": [3043], "full": [3043]}}, "Mitochondrial fatty acid beta oxidation": {"direction": "dw", "overlap": {"value": 5, "mean": 5.689320388349515, "std": 3.4445091417280915, "bin": {}}, "setsize": {"value": 16, "mean": 16.269417475728154, "std": 1.4030952781955324, "bin": {}}, "score": {"value": -2.7422130952727617, "mean": -1.068858573875635, "std": 1.1872455829449722, "bin": {}}, "pval": {"value": 0.0061026736467797, "mean": 0.2804406793294181, "std": 0.2816422091323582, "bin": {}}, "signature_idxs": {"edge": [3176, 3178, 3055, 3191, 3000], "full": [389, 3178, 1031, 3055, 1357, 3176, 1618, 2191, 3000, 391, 2616, 923, 2015, 3191, 2126, 539]}}, "Synthesis of 5 eicosatetraenoic acids": {"direction": "up", "overlap": {"value": 0, "mean": 0.1728723404255319, "std": 0.3781368724963633, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_hit": 3, "bin_50": 3, "bin_100": 3, "bin_250": 3, "bin_500": 3}}, "score": {"value": 2.740971602297092, "mean": 1.859021735804899, "std": 1.996381244471132, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 20.21747967479675, "bin_500": 9.795959595959596}}, "pval": {"value": 0.0061257801640206, "mean": 0.0562056781984062, "std": 0.1270418077334967, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0709359846499108, "bin_500": 0.1389682081054653}}, "signature_idxs": {"edge": [], "full": [176]}}, "Interleukin 2 signaling": {"direction": "dw", "overlap": {"value": 1, "mean": 0.3333333333333333, "std": 0.4714045207910317, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -2.728007948923338, "mean": 0.5801888394853281, "std": 2.111259524330796, "bin": {}}, "pval": {"value": 0.0063718072569227, "mean": 0.2005945736746948, "std": 0.2662990773909733, "bin": {}}, "signature_idxs": {"edge": [3017], "full": [3017]}}, "Triglyceride biosynthesis": {"direction": "up", "overlap": {"value": 0, "mean": 0.183206106870229, "std": 0.386835403338013, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_hit": 7, "bin_50": 7, "bin_100": 7, "bin_250": 7, "bin_500": 7}}, "score": {"value": 2.693251430153426, "mean": 1.6248584984263872, "std": 2.00259360530807, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 6.736449864498645, "bin_500": 3.263973063973064}}, "pval": {"value": 0.0070758885824881, "mean": 0.0926621161918523, "std": 0.1749397300717861, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1577810442013011, "bin_500": 0.2947426943315017}}, "signature_idxs": {"edge": [], "full": [208]}}, "Runx1 regulates estrogen receptor mediated transcription": {"direction": "up", "overlap": {"value": 0, "mean": 0.2949852507374631, "std": 0.4812148923753463, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.2536873156342183, "std": 0.4351207436109232, "bin": {"bin_hit": 5, "bin_50": 5, "bin_100": 5, "bin_250": 5, "bin_500": 5}}, "score": {"value": 2.693251430153426, "mean": 1.1732058398887657, "std": 1.8086643698442468, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 10.106707317073171, "bin_500": 4.8969696969696965}}, "pval": {"value": 0.0070758885824881, "mean": 0.2207623739349291, "std": 0.280217744978931, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1154193350298319, "bin_500": 0.2207303711304172}}, "signature_idxs": {"edge": [], "full": [208]}}, "Cytosolic trna aminoacylation": {"direction": "dw", "overlap": {"value": 12, "mean": 14.300970873786408, "std": 4.932722030504012, "bin": {}}, "setsize": {"value": 23, "mean": 22.966019417475728, "std": 0.1811792000633157, "bin": {}}, "score": {"value": -2.6647961392503743, "mean": -0.9200929801404824, "std": 1.2586096712426873, "bin": {}}, "pval": {"value": 0.007703500624105, "mean": 0.376538997117691, "std": 0.3534678527412684, "bin": {}}, "signature_idxs": {"edge": [2926, 3169, 2641, 2643, 2743, 2645, 2812, 2741, 2681, 2550, 2618, 2650], "full": [2926, 1939, 2186, 2228, 2812, 2681, 1577, 2641, 2741, 1755, 2643, 1662, 2743, 2268, 1542, 2645, 2550, 2618, 2650, 3169, 1223, 1013, 937]}}, "Mitophagy": {"direction": "up", "overlap": {"value": 4, "mean": 3.662621359223301, "std": 1.8155907654273165, "bin": {"bin_hit": 3, "bin_50": 3, "bin_100": 3, "bin_250": 3, "bin_500": 5}}, "setsize": {"value": 12, "mean": 11.783980582524272, "std": 1.3363606860118669, "bin": {"bin_hit": 24, "bin_50": 24, "bin_100": 24, "bin_250": 24, "bin_500": 24}}, "score": {"value": 2.6524922069049808, "mean": 1.3564301304992197, "std": 1.2723890100166135, "bin": {"bin_hit": 12.831632653061224, "bin_50": 31.4472049689441, "bin_100": 15.153383458646616, "bin_250": 5.812646370023419, "bin_500": 5.188659020259406}}, "pval": {"value": 0.0079899972326205, "mean": 0.1917930287367771, "std": 0.2636913304405313, "bin": {"bin_hit": 0.0023802684917652, "bin_50": 0.0001966568602221, "bin_100": 0.0015052123544451, "bin_250": 0.0195244436529747, "bin_500": 0.0052582215982291}}, "signature_idxs": {"edge": [16, 41, 280, 7], "full": [1316, 2735, 651, 1399, 7, 2048, 280, 328, 41, 1052, 1596, 16]}}, "Attachment and entry": {"direction": "dw", "overlap": {"value": 1, "mean": 0.7888349514563107, "std": 0.4368594916874587, "bin": {}}, "setsize": {"value": 1, "mean": 1.046116504854369, "std": 0.2703996790431137, "bin": {}}, "score": {"value": -2.650089354131506, "mean": -0.8106089343366657, "std": 1.3719991493195605, "bin": {}}, "pval": {"value": 0.0080470485211754, "mean": 0.3300673788846759, "std": 0.286268988264632, "bin": {}}, "signature_idxs": {"edge": [2969], "full": [2969]}}, "Androgen biosynthesis": {"direction": "up", "overlap": {"value": 0, "mean": 0.2645631067961165, "std": 0.4411002939451562, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_hit": 2, "bin_50": 2, "bin_100": 2, "bin_250": 2, "bin_500": 2}}, "score": {"value": 2.648656044587528, "mean": 1.1075298957431323, "std": 1.8933465515216856, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 40.4390243902439, "bin_500": 19.593939393939397}}, "pval": {"value": 0.0080812532097735, "mean": 0.1756421194716174, "std": 0.2437268050599615, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0478658316601909, "bin_500": 0.0949311108898137}}, "signature_idxs": {"edge": [], "full": [236]}}, "Nonhomologous end joining nhej": {"direction": "dw", "overlap": {"value": 8, "mean": 7.063106796116505, "std": 3.183833260601603, "bin": {}}, "setsize": {"value": 18, "mean": 17.038834951456312, "std": 2.4904568540111307, "bin": {}}, "score": {"value": -2.631456718759779, "mean": -0.8834282070347159, "std": 0.8466515832232618, "bin": {}}, "pval": {"value": 0.0085019695561503, "mean": 0.4198910771082438, "std": 0.3074696500188786, "bin": {}}, "signature_idxs": {"edge": [2838, 2826, 3018, 2897, 2752, 3060, 3163, 2863], "full": [2182, 1838, 1168, 1065, 1538, 2863, 3018, 1758, 1040, 3060, 1075, 2897, 3163, 2826, 2752, 2424, 2838, 1124]}}, "Metabolism of angiotensinogen to angiotensins": {"direction": "up", "overlap": {"value": 0, "mean": 0.2521739130434782, "std": 0.4342605561455225, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.065217391304348, "std": 0.2469090585130553, "bin": {"bin_hit": 8, "bin_50": 8, "bin_100": 8, "bin_250": 8, "bin_500": 8}}, "score": {"value": 2.62878473112486, "mean": 1.1064115633871696, "std": 1.7967276651499058, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 5.7735191637630665, "bin_500": 2.7974025974025976}}, "pval": {"value": 0.0085690586034279, "mean": 0.1978675139439829, "std": 0.2504782620107884, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1781979724676324, "bin_500": 0.3290745839784397}}, "signature_idxs": {"edge": [], "full": [244]}}, "Synthesis of pyrophosphates in the cytosol": {"direction": "up", "overlap": {"value": 0, "mean": 0.6115702479338843, "std": 0.6560408107280444, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.4545454545454546, "std": 0.5701481127947509, "bin": {"bin_hit": 10, "bin_50": 10, "bin_100": 10, "bin_250": 10, "bin_500": 10}}, "score": {"value": 2.622153997184551, "mean": 0.3273643246169575, "std": 1.6236552298675098, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 2.1753086419753087}}, "pval": {"value": 0.0087375939549325, "mean": 0.3535520588291638, "std": 0.3173517937990548, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.3928150466925536}}, "signature_idxs": {"edge": [], "full": [251]}}, "Copi dependent golgi to er retrograde traffic": {"direction": "up", "overlap": {"value": 21, "mean": 11.182038834951456, "std": 5.23740910141448, "bin": {"bin_hit": 4, "bin_50": 4, "bin_100": 4, "bin_250": 5, "bin_500": 14}}, "setsize": {"value": 52, "mean": 47.99029126213592, "std": 4.001201629295025, "bin": {"bin_hit": 83, "bin_50": 83, "bin_100": 83, "bin_250": 83, "bin_500": 83}}, "score": {"value": 2.620181080730132, "mean": 0.5471026826372138, "std": 0.965332014570292, "bin": {"bin_hit": 4.562435853575094, "bin_50": 11.328270042194092, "bin_100": 5.396714247239429, "bin_250": 2.614695910150456, "bin_500": 4.054182452342293}}, "pval": {"value": 0.0087883087724436, "mean": 0.5756044604671363, "std": 0.3600502859002751, "bin": {"bin_hit": 0.0142580150800809, "bin_50": 0.0006546615435026, "bin_100": 0.0082628338092705, "bin_250": 0.0506666012040158, "bin_500": 4.141795596004192e-05}}, "signature_idxs": {"edge": [2, 259, 390, 404, 657, 531, 29, 30, 36, 417, 420, 691, 444, 710, 320, 458, 596, 612, 100, 500, 378], "full": [1352, 1233, 2635, 259, 2304, 36, 1574, 2312, 1535, 390, 1169, 2, 972, 990, 2503, 1069, 417, 596, 2504, 2267, 2547, 657, 531, 320, 458, 2152, 1511, 778, 420, 691, 612, 2325, 29, 737, 500, 1679, 1215, 1927, 2780, 2168, 378, 404, 444, 2170, 1007, 1928, 961, 100, 1933, 30, 857, 710]}}, "Transport to the golgi and subsequent modification": {"direction": "up", "overlap": {"value": 33, "mean": 20.604368932038835, "std": 8.044251420264837, "bin": {"bin_hit": 4, "bin_50": 4, "bin_100": 4, "bin_250": 7, "bin_500": 25}}, "setsize": {"value": 85, "mean": 77.1626213592233, "std": 7.0373663516482345, "bin": {"bin_hit": 148, "bin_50": 148, "bin_100": 148, "bin_250": 148, "bin_500": 148}}, "score": {"value": 2.617551679850799, "mean": 0.4958457957496105, "std": 0.9638132242129624, "bin": {"bin_hit": 2.486736736736737, "bin_50": 6.174691358024691, "bin_100": 2.941489361702128, "bin_250": 2.028841607565012, "bin_500": 4.132791327913279}}, "pval": {"value": 0.0088563076414511, "mean": 0.6299790557050085, "std": 0.3700222187340509, "bin": {"bin_hit": 0.0861119593099057, "bin_50": 0.0054425252263289, "bin_100": 0.0540831694948363, "bin_250": 0.0682104000582474, "bin_500": 4.161322882163794e-08}}, "signature_idxs": {"edge": [2, 639, 390, 398, 400, 404, 657, 531, 29, 30, 36, 417, 674, 691, 444, 440, 320, 325, 458, 476, 348, 612, 604, 354, 490, 231, 362, 487, 500, 240, 244, 378, 386], "full": [1532, 2635, 798, 3157, 1394, 604, 1101, 1837, 36, 398, 2137, 1574, 240, 2447, 348, 1194, 942, 400, 390, 1169, 2, 990, 2503, 2865, 1754, 1069, 867, 417, 2266, 2504, 2267, 487, 2321, 2547, 440, 831, 657, 531, 1624, 320, 833, 458, 1327, 325, 490, 2551, 354, 812, 691, 813, 1041, 612, 639, 1913, 674, 29, 998, 362, 1172, 1116, 500, 1679, 1214, 1259, 1215, 1681, 2759, 1347, 386, 2168, 378, 404, 444, 961, 1183, 744, 2295, 1933, 244, 231, 986, 30, 710, 1162, 476]}}, "Copi mediated anterograde transport": {"direction": "up", "overlap": {"value": 24, "mean": 14.364077669902912, "std": 6.303679837135847, "bin": {"bin_hit": 4, "bin_50": 4, "bin_100": 4, "bin_250": 6, "bin_500": 16}}, "setsize": {"value": 60, "mean": 53.29368932038835, "std": 4.572358803691129, "bin": {"bin_hit": 89, "bin_50": 89, "bin_100": 89, "bin_250": 89, "bin_500": 89}}, "score": {"value": 2.6130267731891115, "mean": 0.4832864212749729, "std": 1.0202251873333663, "bin": {"bin_hit": 4.237837837837838, "bin_50": 10.52235294117647, "bin_100": 5.012765957446809, "bin_250": 2.959356096585512, "bin_500": 4.395890410958904}}, "pval": {"value": 0.0089744271609324, "mean": 0.5898511157237575, "std": 0.3614704266753352, "bin": {"bin_hit": 0.0180001337834958, "bin_50": 0.0008516763691692, "bin_100": 0.0105112684317993, "bin_250": 0.0207913960921613, "bin_500": 5.060527170582115e-06}}, "signature_idxs": {"edge": [2, 639, 390, 404, 657, 531, 29, 30, 36, 417, 674, 691, 444, 320, 325, 458, 348, 612, 604, 354, 231, 500, 240, 378], "full": [2635, 798, 3157, 604, 1101, 36, 2137, 240, 348, 390, 1169, 2, 990, 2503, 2865, 1754, 1069, 417, 2266, 2504, 2267, 2547, 831, 657, 531, 1624, 320, 833, 458, 1327, 325, 2551, 354, 812, 691, 813, 1041, 612, 639, 1913, 674, 29, 500, 1679, 1214, 1215, 2759, 1347, 2168, 378, 404, 444, 961, 1183, 2295, 1933, 231, 30, 710, 1162]}}, "Defects of contact activation system cas and kallikrein kinin system kks": {"direction": "up", "overlap": {"value": 0, "mean": 0.1561712846347607, "std": 0.3630176503839576, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_hit": 5, "bin_50": 5, "bin_100": 5, "bin_250": 5, "bin_500": 5}}, "score": {"value": 2.610541857235539, "mean": 1.5804308436774324, "std": 1.73780271313283, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 4.8969696969696965}}, "pval": {"value": 0.0090398908489153, "mean": 0.1317088711767676, "std": 0.2063748824538425, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.2207303711304172}}, "signature_idxs": {"edge": [], "full": [255]}}, "Gamma carboxylation transport and amino terminal cleavage of proteins": {"direction": "up", "overlap": {"value": 0, "mean": 0.1561712846347607, "std": 0.3630176503839576, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_hit": 5, "bin_50": 5, "bin_100": 5, "bin_250": 5, "bin_500": 5}}, "score": {"value": 2.610541857235539, "mean": 1.5804308436774324, "std": 1.73780271313283, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 4.8969696969696965}}, "pval": {"value": 0.0090398908489153, "mean": 0.1317088711767676, "std": 0.2063748824538425, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.2207303711304172}}, "signature_idxs": {"edge": [], "full": [255]}}, "Defective factor ix causes hemophilia b": {"direction": "up", "overlap": {"value": 0, "mean": 0.1561712846347607, "std": 0.3630176503839576, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_hit": 3, "bin_50": 3, "bin_100": 3, "bin_250": 3, "bin_500": 3}}, "score": {"value": 2.610541857235539, "mean": 1.5804308436774324, "std": 1.73780271313283, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 9.795959595959596}}, "pval": {"value": 0.0090398908489153, "mean": 0.1317088711767676, "std": 0.2063748824538425, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.1389682081054653}}, "signature_idxs": {"edge": [], "full": [255]}}, "Epigenetic regulation of gene expression": {"direction": "dw", "overlap": {"value": 21, "mean": 19.41747572815534, "std": 7.137381793821183, "bin": {}}, "setsize": {"value": 44, "mean": 42.99514563106796, "std": 4.250639669526318, "bin": {}}, "score": {"value": -2.6091821031101987, "mean": -1.2342556202270925, "std": 1.1738716287747466, "bin": {}}, "pval": {"value": 0.0090758929928158, "mean": 0.3568884878092889, "std": 0.3574577146020241, "bin": {}}, "signature_idxs": {"edge": [2834, 2339, 2478, 2486, 2965, 2445, 3109, 3118, 2382, 2863, 2344, 3015, 2915, 3171, 2914, 2805, 2562, 2699, 2566, 3060, 2405], "full": [2344, 3118, 2445, 3109, 2965, 1884, 2183, 1494, 1987, 1707, 3015, 2863, 2091, 569, 1135, 916, 1655, 2405, 1071, 3060, 2051, 1460, 1629, 1079, 1369, 782, 2914, 2915, 2478, 2834, 2699, 2562, 1823, 2805, 2382, 2566, 2486, 2123, 1931, 1777, 1349, 3171, 2339, 1351]}}, "Zinc influx into cells by the slc39 gene family": {"direction": "up", "overlap": {"value": 0, "mean": 0.2251082251082251, "std": 0.4378932854165123, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.1125541125541123, "std": 0.3547671211869763, "bin": {"bin_hit": 7, "bin_50": 7, "bin_100": 7, "bin_250": 7, "bin_500": 7}}, "score": {"value": 2.60888211320146, "mean": 1.4618360850098455, "std": 1.7629371554910065, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 3.263973063973064}}, "pval": {"value": 0.0090838530265275, "mean": 0.1545050932421011, "std": 0.250222037228711, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.2947426943315017}}, "signature_idxs": {"edge": [], "full": [256]}}, "G alpha q signalling events": {"direction": "dw", "overlap": {"value": 1, "mean": 2.8567961165048543, "std": 1.7477801252441654, "bin": {}}, "setsize": {"value": 11, "mean": 12.349514563106796, "std": 2.6253385833016627, "bin": {}}, "score": {"value": -2.580623153097463, "mean": -1.2201103518730343, "std": 1.1290382202140006, "bin": {}}, "pval": {"value": 0.0098622172948463, "mean": 0.2572818502952295, "std": 0.2921395940828384, "bin": {}}, "signature_idxs": {"edge": [3192], "full": [1490, 1889, 438, 2892, 1136, 1140, 1142, 2099, 953, 203, 3192]}}, "Keratan sulfate biosynthesis": {"direction": "up", "overlap": {"value": 0, "mean": 0.4101941747572815, "std": 0.5946304728058994, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.3349514563106797, "std": 0.6266273939490626, "bin": {"bin_hit": 11, "bin_50": 11, "bin_100": 11, "bin_250": 11, "bin_500": 11}}, "score": {"value": 2.5789697779375818, "mean": 1.163530760409998, "std": 1.912288808565062, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 1.9575757575757573}}, "pval": {"value": 0.0099095455945414, "mean": 0.164014848011524, "std": 0.2357523358731849, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.4223814846322101}}, "signature_idxs": {"edge": [], "full": [275]}}, "Diseases associated with o glycosylation of proteins": {"direction": "up", "overlap": {"value": 0, "mean": 0.4174757281553398, "std": 0.5956846732906611, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.5218446601941749, "std": 0.6129734113760651, "bin": {"bin_hit": 17, "bin_50": 17, "bin_100": 17, "bin_250": 17, "bin_500": 17}}, "score": {"value": 2.5789697779375818, "mean": 0.9800294130852574, "std": 1.742276704521334, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 1.2227272727272729}}, "pval": {"value": 0.0099095455945414, "mean": 0.2589966371269667, "std": 0.3065542429149289, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.5719289219770226}}, "signature_idxs": {"edge": [], "full": [275]}}, "Na cl dependent neurotransmitter transporters": {"direction": "up", "overlap": {"value": 0, "mean": 0.2486187845303867, "std": 0.4322123141570817, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_hit": 4, "bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 2.553989597766364, "mean": 1.337503383126807, "std": 1.9735796945517308, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 6.52996632996633}}, "pval": {"value": 0.0106496438091596, "mean": 0.1405513887703054, "std": 0.2250263727834427, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.1808667432566313}}, "signature_idxs": {"edge": [], "full": [289]}}, "A tetrasaccharide linker sequence is required for gag synthesis": {"direction": "up", "overlap": {"value": 0, "mean": 0.3973063973063973, "std": 0.5095645632967707, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.1313131313131313, "std": 0.3377424948949593, "bin": {"bin_hit": 16, "bin_50": 16, "bin_100": 16, "bin_250": 16, "bin_500": 16}}, "score": {"value": 2.5506552681095265, "mean": 0.45713081522496, "std": 2.020892606866953, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 1.3043771043771044}}, "pval": {"value": 0.0107520618868202, "mean": 0.2157135109124441, "std": 0.2748256479080779, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.5500037614421638}}, "signature_idxs": {"edge": [], "full": [291]}}, "Beta oxidation of decanoyl coa to octanoyl coa coa": {"direction": "dw", "overlap": {"value": 3, "mean": 2.2936893203883497, "std": 1.3666126291804346, "bin": {}}, "setsize": {"value": 6, "mean": 5.162621359223301, "std": 0.3690198541375071, "bin": {}}, "score": {"value": -2.530001423795182, "mean": -0.6449789875689896, "std": 1.2261240134609026, "bin": {}}, "pval": {"value": 0.0114062063799682, "mean": 0.3122923607106103, "std": 0.2806179059176082, "bin": {}}, "signature_idxs": {"edge": [3176, 3055, 3191], "full": [3055, 3176, 1618, 2616, 923, 3191]}}, "Akt phosphorylates targets in the nucleus": {"direction": "up", "overlap": {"value": 0, "mean": 0.3826086956521739, "std": 0.5529778468029442, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.3304347826086955, "std": 0.5756670605369666, "bin": {"bin_hit": 9, "bin_50": 9, "bin_100": 9, "bin_250": 9, "bin_500": 9}}, "score": {"value": 2.513921458586696, "mean": 1.2357286771907483, "std": 1.6064634687667751, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 2.447474747474748}}, "pval": {"value": 0.0119397020843223, "mean": 0.2179285079888427, "std": 0.2588345796932688, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.36173840478418}}, "signature_idxs": {"edge": [], "full": [313]}}, "Runx2 regulates genes involved in cell migration": {"direction": "up", "overlap": {"value": 0, "mean": 0.4720670391061452, "std": 0.586678631564853, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.6340782122905029, "std": 0.6952838852106926, "bin": {"bin_hit": 5, "bin_50": 5, "bin_100": 5, "bin_250": 5, "bin_500": 5}}, "score": {"value": 2.513921458586696, "mean": 1.0202612189411668, "std": 1.4141525202568348, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 4.8969696969696965}}, "pval": {"value": 0.0119397020843223, "mean": 0.3350810536365994, "std": 0.3189479641011906, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.2207303711304172}}, "signature_idxs": {"edge": [], "full": [313]}}, "Chrebp activates metabolic gene expression": {"direction": "dw", "overlap": {"value": 2, "mean": 2.237864077669903, "std": 0.9093491222766504, "bin": {}}, "setsize": {"value": 4, "mean": 4.800970873786408, "std": 0.439769389176325, "bin": {}}, "score": {"value": -2.505785100103522, "mean": -1.5566688432319424, "std": 1.1341902832414952, "bin": {}}, "pval": {"value": 0.0122179853457495, "mean": 0.1586667932981373, "std": 0.2412166252408147, "bin": {}}, "signature_idxs": {"edge": [3164, 3190], "full": [3164, 1401, 1455, 3190]}}, "Acyl chain remodelling of pc": {"direction": "up", "overlap": {"value": 0, "mean": 0.7445255474452555, "std": 0.7548306435500738, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.8394160583941608, "std": 0.9114057747583176, "bin": {"bin_hit": 9, "bin_50": 9, "bin_100": 9, "bin_250": 9, "bin_500": 9}}, "score": {"value": 2.505558566527261, "mean": 0.5434108593850304, "std": 1.60855215492092, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 2.447474747474748}}, "pval": {"value": 0.0122258149045728, "mean": 0.3347143413864514, "std": 0.309993750104757, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.36173840478418}}, "signature_idxs": {"edge": [], "full": [318]}}, "Tight junction interactions": {"direction": "dw", "overlap": {"value": 1, "mean": 0.7774798927613941, "std": 0.6801096566275604, "bin": {}}, "setsize": {"value": 1, "mean": 1.7024128686327078, "std": 0.7211248073089954, "bin": {}}, "score": {"value": -2.5028242054739103, "mean": -0.1063160338286054, "std": 1.5494026024745255, "bin": {}}, "pval": {"value": 0.0123206724372164, "mean": 0.4125569176533025, "std": 0.343800832536018, "bin": {}}, "signature_idxs": {"edge": [2904], "full": [2904]}}, "Maturation of sars cov 1 nucleoprotein": {"direction": "dw", "overlap": {"value": 1, "mean": 0.819718309859155, "std": 0.7010293675530229, "bin": {}}, "setsize": {"value": 1, "mean": 1.6225352112676057, "std": 0.5551797534306537, "bin": {}}, "score": {"value": -2.492718854078899, "mean": 0.130441766743843, "std": 1.4272108137621713, "bin": {}}, "pval": {"value": 0.0126769179138044, "mean": 0.4454232783656918, "std": 0.3386072412679707, "bin": {}}, "signature_idxs": {"edge": [2867], "full": [2867]}}, "Notch2 activation and transmission of signal to the nucleus": {"direction": "up", "overlap": {"value": 0, "mean": 0.4628712871287129, "std": 0.6142754512168384, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.4084158415841583, "std": 0.6441115343323198, "bin": {"bin_hit": 16, "bin_50": 16, "bin_100": 16, "bin_250": 16, "bin_500": 16}}, "score": {"value": 2.488816993176323, "mean": 0.8075260096372746, "std": 1.656919946354968, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 1.3043771043771044}}, "pval": {"value": 0.0128168921525366, "mean": 0.2938474667870283, "std": 0.3170575803742138, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.5500037614421638}}, "signature_idxs": {"edge": [], "full": [329]}}, "Signaling by notch2": {"direction": "up", "overlap": {"value": 0, "mean": 0.6155717761557178, "std": 0.7337208785180127, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.9221411192214113, "std": 0.900808660515144, "bin": {"bin_hit": 22, "bin_50": 22, "bin_100": 22, "bin_250": 22, "bin_500": 22}}, "score": {"value": 2.488816993176323, "mean": 0.5322610754482243, "std": 1.4308991541544014, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.9311207311207312}}, "pval": {"value": 0.0128168921525366, "mean": 0.4179363696503314, "std": 0.3466125562354748, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.6665596814409742}}, "signature_idxs": {"edge": [], "full": [329]}}, "Nrif signals cell death from the nucleus": {"direction": "up", "overlap": {"value": 0, "mean": 0.5594059405940595, "std": 0.5835497752229274, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.5792079207920793, "std": 0.5550518362525793, "bin": {"bin_hit": 14, "bin_50": 14, "bin_100": 14, "bin_250": 14, "bin_500": 14}}, "score": {"value": 2.488816993176323, "mean": 0.7430716785575665, "std": 1.6012152409463305, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 1.5053613053613053}}, "pval": {"value": 0.0128168921525366, "mean": 0.3300762213132749, "std": 0.3235566839962863, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.5027345059494577}}, "signature_idxs": {"edge": [], "full": [329]}}, "Synthesis of lipoxins lx": {"direction": "dw", "overlap": {"value": 1, "mean": 0.5833333333333334, "std": 0.4930066485916347, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -2.4809189724413225, "mean": -0.5057022636076103, "std": 2.471789258852145, "bin": {}}, "pval": {"value": 0.0131044158025481, "mean": 0.1181345642845522, "std": 0.2119915712060405, "bin": {}}, "signature_idxs": {"edge": [2873], "full": [2873]}}, "Alpha protein kinase 1 signaling pathway": {"direction": "dw", "overlap": {"value": 1, "mean": 0.9411764705882352, "std": 0.6389870877176598, "bin": {}}, "setsize": {"value": 1, "mean": 1.3689839572192513, "std": 0.4825295809938215, "bin": {}}, "score": {"value": -2.477545543099131, "mean": -0.7505963350349926, "std": 1.5918130026823043, "bin": {}}, "pval": {"value": 0.013228952434928, "mean": 0.3262468297984152, "std": 0.3087659449687511, "bin": {}}, "signature_idxs": {"edge": [2875], "full": [2875]}}, "Irak2 mediated activation of tak1 complex": {"direction": "dw", "overlap": {"value": 1, "mean": 0.9411764705882352, "std": 0.6389870877176598, "bin": {}}, "setsize": {"value": 1, "mean": 1.3689839572192513, "std": 0.4825295809938215, "bin": {}}, "score": {"value": -2.477545543099131, "mean": -0.7505963350349926, "std": 1.5918130026823043, "bin": {}}, "pval": {"value": 0.013228952434928, "mean": 0.3262468297984152, "std": 0.3087659449687511, "bin": {}}, "signature_idxs": {"edge": [2875], "full": [2875]}}, "Ticam1 traf6 dependent induction of tak1 complex": {"direction": "dw", "overlap": {"value": 1, "mean": 0.9411764705882352, "std": 0.6389870877176598, "bin": {}}, "setsize": {"value": 1, "mean": 1.3689839572192513, "std": 0.4825295809938215, "bin": {}}, "score": {"value": -2.477545543099131, "mean": -0.7505963350349926, "std": 1.5918130026823043, "bin": {}}, "pval": {"value": 0.013228952434928, "mean": 0.3262468297984152, "std": 0.3087659449687511, "bin": {}}, "signature_idxs": {"edge": [2875], "full": [2875]}}, "Synthesis of pe": {"direction": "up", "overlap": {"value": 0, "mean": 0.7901234567901234, "std": 0.7522156471518984, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 2.237037037037037, "std": 0.7653683764793772, "bin": {"bin_hit": 12, "bin_50": 12, "bin_100": 12, "bin_250": 12, "bin_500": 12}}, "score": {"value": 2.468699450782794, "mean": 1.1136905237616417, "std": 1.291303912107451, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 1.779430670339761}}, "pval": {"value": 0.0135605058676115, "mean": 0.2852934551021182, "std": 0.2805694594942842, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.4505109675601652}}, "signature_idxs": {"edge": [], "full": [340]}}, "Negative epigenetic regulation of rrna expression": {"direction": "dw", "overlap": {"value": 11, "mean": 10.021844660194176, "std": 3.995386720185007, "bin": {}}, "setsize": {"value": 24, "mean": 23.725728155339805, "std": 2.969099468568849, "bin": {}}, "score": {"value": -2.4589482608396547, "mean": -1.089822822238336, "std": 0.9351033783141092, "bin": {}}, "pval": {"value": 0.0139344697948331, "mean": 0.3700014384633002, "std": 0.3241716408405726, "bin": {}}, "signature_idxs": {"edge": [2965, 3171, 2914, 2445, 3109, 3118, 2699, 2566, 3060, 2486, 2863], "full": [3118, 2445, 3109, 2965, 1884, 1707, 2863, 2091, 569, 1135, 916, 1655, 1071, 3060, 2051, 1079, 2914, 2699, 1823, 2566, 2486, 2123, 1349, 3171]}}, "Rho gtpases activate iqgaps": {"direction": "up", "overlap": {"value": 7, "mean": 4.924757281553398, "std": 2.979162045691005, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 6}}, "setsize": {"value": 12, "mean": 10.973300970873789, "std": 1.3207697728641727, "bin": {"bin_hit": 26, "bin_50": 26, "bin_100": 26, "bin_250": 26, "bin_500": 26}}, "score": {"value": 2.453817788377873, "mean": 0.1392446665740701, "std": 0.9184481670839386, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 1.613658536585366, "bin_500": 5.926530612244898}}, "pval": {"value": 0.0141348583821498, "mean": 0.6096259755368159, "std": 0.3154644259160195, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.4718643991127431, "bin_500": 0.0012863968531589}}, "signature_idxs": {"edge": [612, 320, 135, 390, 433, 404, 378], "full": [390, 2189, 1502, 1323, 1622, 320, 691, 135, 612, 433, 378, 404]}}, "Mrna splicing minor pathway": {"direction": "dw", "overlap": {"value": 14, "mean": 13.5873786407767, "std": 5.472316554100434, "bin": {}}, "setsize": {"value": 33, "mean": 32.04126213592233, "std": 2.337068605999584, "bin": {}}, "score": {"value": -2.45333191838004, "mean": -0.9003267276000921, "std": 1.0294126267209205, "bin": {}}, "pval": {"value": 0.0141539669155492, "mean": 0.4356302072478651, "std": 0.3422370166243823, "bin": {}}, "signature_idxs": {"edge": [2851, 3172, 2914, 2710, 3026, 3145, 2717, 2799, 2540, 2510, 2937, 2723, 2619, 3162], "full": [2710, 1494, 2138, 2139, 2041, 2717, 1135, 2540, 447, 339, 1071, 3162, 2723, 1509, 2234, 3172, 2937, 832, 1077, 2851, 2619, 2510, 2799, 2914, 1207, 2060, 1144, 1417, 3145, 1868, 1478, 3026, 1568]}}, "Er to golgi anterograde transport": {"direction": "up", "overlap": {"value": 30, "mean": 19.152912621359224, "std": 7.637631429097237, "bin": {"bin_hit": 4, "bin_50": 4, "bin_100": 4, "bin_250": 7, "bin_500": 22}}, "setsize": {"value": 82, "mean": 74.15776699029126, "std": 6.107600140782552, "bin": {"bin_hit": 129, "bin_50": 129, "bin_100": 129, "bin_250": 129, "bin_500": 129}}, "score": {"value": 2.444582746062736, "mean": 0.4357486981835305, "std": 0.9360192475456132, "bin": {"bin_hit": 2.870198198198198, "bin_50": 7.126755555555556, "bin_100": 3.395063829787234, "bin_250": 2.3493510928961747, "bin_500": 4.16116566110651}}, "pval": {"value": 0.014501981003465, "mean": 0.6456866134420882, "std": 0.3613336360589621, "bin": {"bin_hit": 0.0578908741779334, "bin_50": 0.003337104959027, "bin_100": 0.03553181045856, "bin_250": 0.0372071493283512, "bin_500": 2.288729808751107e-07}}, "signature_idxs": {"edge": [2, 639, 390, 404, 657, 531, 29, 30, 36, 417, 674, 691, 444, 440, 320, 325, 458, 476, 348, 612, 604, 354, 490, 231, 487, 500, 240, 244, 378, 386], "full": [1532, 2635, 798, 3157, 1394, 604, 1101, 1837, 36, 2137, 1574, 240, 2447, 348, 1194, 942, 390, 1169, 2, 990, 2503, 2865, 1754, 1069, 867, 417, 2266, 2504, 2267, 487, 2321, 2547, 440, 831, 657, 531, 1624, 320, 833, 458, 1327, 325, 490, 2551, 354, 812, 691, 813, 1041, 612, 639, 1913, 674, 29, 998, 1172, 1116, 500, 1679, 1214, 1259, 1215, 1681, 2759, 1347, 386, 2168, 378, 404, 444, 961, 1183, 744, 2295, 1933, 244, 231, 986, 30, 710, 1162, 476]}}, "Recruitment of numa to mitotic centrosomes": {"direction": "up", "overlap": {"value": 24, "mean": 11.883495145631068, "std": 5.3811987888681685, "bin": {"bin_hit": 1, "bin_50": 0, "bin_100": 0, "bin_250": 3, "bin_500": 11}}, "setsize": {"value": 36, "mean": 35.75485436893204, "std": 4.283134766195611, "bin": {"bin_hit": 90, "bin_50": 90, "bin_100": 90, "bin_250": 90, "bin_500": 90}}, "score": {"value": 2.431817988238312, "mean": 0.624756920034884, "std": 1.0244661495687433, "bin": {"bin_hit": 0.9848216045732308, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 1.3937252685132844, "bin_500": 2.7621297142111443}}, "pval": {"value": 0.0150232546099517, "mean": 0.5097170288431273, "std": 0.3603491445972374, "bin": {"bin_hit": 0.6413396664902387, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.3727622753153998, "bin_500": 0.0041393793420635}}, "signature_idxs": {"edge": [639, 390, 401, 404, 917, 290, 812, 813, 959, 691, 576, 574, 439, 320, 585, 197, 583, 831, 741, 612, 240, 118, 376, 378], "full": [240, 290, 118, 390, 439, 401, 1063, 917, 1658, 583, 1107, 831, 2410, 1623, 1624, 320, 812, 691, 813, 612, 2274, 639, 1913, 2776, 585, 1916, 976, 376, 574, 741, 576, 2381, 959, 378, 404, 197]}}, "Positive epigenetic regulation of rrna expression": {"direction": "dw", "overlap": {"value": 14, "mean": 14.16747572815534, "std": 5.601543687797506, "bin": {}}, "setsize": {"value": 28, "mean": 28.83495145631068, "std": 2.4449158159654645, "bin": {}}, "score": {"value": -2.424596218496386, "mean": -1.162471689203394, "std": 1.0574615836436132, "bin": {}}, "pval": {"value": 0.015325421577466, "mean": 0.3493309276909624, "std": 0.3383903298109247, "bin": {}}, "signature_idxs": {"edge": [2834, 2344, 2445, 3109, 2562, 2339, 2699, 3015, 2566, 3060, 2478, 2382, 2405, 2863], "full": [2344, 2445, 3109, 1884, 1494, 1987, 1707, 3015, 2863, 1135, 2405, 1071, 3060, 2051, 1460, 1629, 1079, 1369, 2478, 2834, 2699, 2562, 2382, 2566, 2123, 1931, 1777, 2339]}}, "Mitochondrial protein import": {"direction": "up", "overlap": {"value": 18, "mean": 13.468446601941748, "std": 6.078090089851624, "bin": {"bin_hit": 6, "bin_50": 5, "bin_100": 6, "bin_250": 8, "bin_500": 13}}, "setsize": {"value": 35, "mean": 34.5873786407767, "std": 2.2108812815475147, "bin": {"bin_hit": 59, "bin_50": 59, "bin_100": 59, "bin_250": 59, "bin_500": 59}}, "score": {"value": 2.4228241161050983, "mean": 1.6025718162972953, "std": 1.8878681708577505, "bin": {"bin_hit": 10.41509433962264, "bin_50": 21.23947811447812, "bin_100": 12.360541427399507, "bin_250": 6.496349167281975, "bin_500": 5.648663246016743}}, "pval": {"value": 0.0154003809082319, "mean": 0.1874419874946837, "std": 0.2901223460226844, "bin": {"bin_hit": 5.001031602097819e-05, "bin_50": 8.566885380985011e-06, "bin_100": 2.0183366808761614e-05, "bin_250": 8.072563296445924e-05, "bin_500": 3.774726798150127e-06}}, "signature_idxs": {"edge": [0, 3, 7, 41, 414, 332, 625, 16, 338, 51, 557, 211, 497, 280, 217, 527, 651, 428], "full": [211, 414, 0, 3066, 1610, 2788, 527, 1316, 651, 1134, 752, 3129, 338, 217, 7, 1997, 3155, 1507, 497, 51, 280, 557, 625, 41, 2832, 3, 3009, 2253, 16, 698, 428, 1230, 332, 1703, 1272]}}, "Mitochondrial calcium ion transport": {"direction": "up", "overlap": {"value": 7, "mean": 6.502427184466019, "std": 3.410790121717641, "bin": {"bin_hit": 2, "bin_50": 2, "bin_100": 2, "bin_250": 3, "bin_500": 6}}, "setsize": {"value": 16, "mean": 16.12135922330097, "std": 1.246287729205551, "bin": {"bin_hit": 21, "bin_50": 21, "bin_100": 21, "bin_250": 21, "bin_500": 21}}, "score": {"value": 2.399756139717491, "mean": 1.0650233237312683, "std": 1.626144580445205, "bin": {"bin_hit": 9.37307871448533, "bin_50": 22.68309070548712, "bin_100": 11.051535087719298, "bin_250": 6.783469945355192, "bin_500": 7.906122448979592}}, "pval": {"value": 0.0164059973188865, "mean": 0.2089377868120644, "std": 0.28031724173526, "bin": {"bin_hit": 0.0230291928881344, "bin_50": 0.0044823878286489, "bin_100": 0.0170518298819148, "bin_250": 0.0135296171343662, "bin_500": 0.0003730251283681}}, "signature_idxs": {"edge": [297, 7, 15, 502, 247, 410, 155], "full": [2788, 155, 7, 1796, 15, 497, 410, 876, 502, 1819, 932, 678, 297, 824, 247, 1019]}}, "Integration of energy metabolism": {"direction": "dw", "overlap": {"value": 3, "mean": 5.577669902912621, "std": 2.8329350123572894, "bin": {}}, "setsize": {"value": 21, "mean": 22.546116504854368, "std": 2.3832566170959164, "bin": {}}, "score": {"value": -2.3921439689732, "mean": -1.22441944578587, "std": 1.0613259456483748, "bin": {}}, "pval": {"value": 0.0167502704817987, "mean": 0.3504280546682903, "std": 0.3338926667160993, "bin": {}}, "signature_idxs": {"edge": [3164, 3173, 3190], "full": [3164, 553, 1985, 1750, 2535, 225, 863, 2141, 2843, 3173, 917, 828, 1658, 2046, 1323, 1401, 1455, 2195, 2099, 3190, 2155]}}, "Transport of small molecules": {"direction": "up", "overlap": {"value": 57, "mean": 41.730582524271846, "std": 14.87709311863932, "bin": {"bin_hit": 11, "bin_50": 5, "bin_100": 11, "bin_250": 29, "bin_500": 49}}, "setsize": {"value": 147, "mean": 151.96601941747574, "std": 12.598305121005488, "bin": {"bin_hit": 377, "bin_50": 377, "bin_100": 377, "bin_250": 377, "bin_500": 377}}, "score": {"value": 2.385759406768935, "mean": 1.4265613612661356, "std": 1.746958952072276, "bin": {"bin_hit": 2.807508406893653, "bin_50": 2.986009286412512, "bin_100": 3.361974750329753, "bin_250": 3.670107033639144, "bin_500": 3.132182026518252}}, "pval": {"value": 0.0170438973361666, "mean": 0.380396759556163, "std": 0.4128488770716938, "bin": {"bin_hit": 0.003467938807723, "bin_50": 0.0338882845095652, "bin_100": 0.0009538253769808, "bin_250": 3.1798524403343675e-08, "bin_500": 2.1158819836286728e-10}}, "signature_idxs": {"edge": [256, 129, 381, 7, 138, 265, 137, 515, 13, 15, 17, 402, 151, 410, 154, 411, 155, 157, 288, 289, 165, 297, 168, 169, 170, 43, 300, 419, 50, 552, 54, 184, 570, 317, 65, 321, 69, 71, 582, 457, 580, 338, 87, 466, 217, 225, 101, 230, 105, 361, 485, 232, 502, 247, 497, 495, 507], "full": [232, 2346, 2709, 1835, 2393, 858, 552, 170, 2788, 2223, 3153, 2311, 2764, 155, 485, 265, 712, 2449, 361, 2313, 1652, 129, 727, 1990, 17, 225, 863, 338, 217, 2141, 300, 2143, 580, 1499, 970, 1846, 2639, 1280, 7, 2680, 595, 2908, 3124, 137, 2893, 570, 381, 495, 515, 69, 3043, 1658, 888, 1796, 288, 776, 317, 3101, 1659, 1617, 582, 2864, 973, 2967, 15, 1070, 2644, 65, 891, 3156, 184, 1584, 169, 2004, 636, 2269, 2969, 2409, 402, 507, 466, 457, 419, 2458, 2617, 2747, 2460, 2099, 994, 1952, 1625, 733, 497, 1365, 1911, 714, 1668, 2273, 1807, 157, 1410, 256, 899, 230, 2328, 954, 50, 2112, 410, 1299, 876, 105, 101, 929, 43, 502, 1819, 138, 1344, 932, 1424, 2481, 678, 411, 321, 297, 631, 165, 13, 1973, 289, 1599, 87, 2808, 168, 154, 54, 936, 1980, 824, 1228, 2341, 1015, 247, 71, 1019, 151]}}, "Rmts methylate histone arginines": {"direction": "dw", "overlap": {"value": 8, "mean": 8.03640776699029, "std": 3.5143443516644175, "bin": {}}, "setsize": {"value": 20, "mean": 19.75242718446602, "std": 1.2095369137272214, "bin": {}}, "score": {"value": -2.3844298874828924, "mean": -0.8892018486438771, "std": 0.8231477211085879, "bin": {}}, "pval": {"value": 0.0171056071806137, "mean": 0.4478409552947577, "std": 0.3310534804410087, "bin": {}}, "signature_idxs": {"edge": [3045, 3177, 2797, 3060, 2882, 2697, 2765, 2863], "full": [1984, 1163, 1165, 2765, 652, 1843, 2863, 1245, 2797, 3060, 3045, 2111, 2208, 2697, 1637, 2378, 1088, 1641, 2882, 3177]}}, "Pink1 prkn mediated mitophagy": {"direction": "up", "overlap": {"value": 4, "mean": 3.2815533980582523, "std": 1.6230588150315317, "bin": {"bin_hit": 3, "bin_50": 3, "bin_100": 3, "bin_250": 3, "bin_500": 5}}, "setsize": {"value": 9, "mean": 8.473300970873787, "std": 0.9738153254376878, "bin": {"bin_hit": 17, "bin_50": 17, "bin_100": 17, "bin_250": 17, "bin_500": 17}}, "score": {"value": 2.38023755947694, "mean": 1.395617281862234, "std": 1.3577427922485954, "bin": {"bin_hit": 19.26084183673469, "bin_50": 47.203416149068325, "bin_100": 22.74586466165413, "bin_250": 8.725117096018735, "bin_500": 8.221317040054311}}, "pval": {"value": 0.0173014801933255, "mean": 0.1554977461962819, "std": 0.2414588001366878, "bin": {"bin_hit": 0.0008469789066628, "bin_50": 6.765318543664244e-05, "bin_100": 0.0005309775927247, "bin_250": 0.0074273483269255, "bin_500": 0.0010145405611514}}, "signature_idxs": {"edge": [16, 41, 280, 7], "full": [1316, 2735, 651, 7, 280, 328, 41, 1052, 16]}}, "N glycan trimming and elongation in the cis golgi": {"direction": "up", "overlap": {"value": 0, "mean": 0.547244094488189, "std": 0.6667971124988309, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.4606299212598426, "std": 0.6673083174970781, "bin": {"bin_hit": 4, "bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 2.3710461964233662, "mean": 0.7089622202775997, "std": 1.8589944520404704, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 6.52996632996633}}, "pval": {"value": 0.0177378139077397, "mean": 0.2822931901772597, "std": 0.3222709048987781, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.1808667432566313}}, "signature_idxs": {"edge": [], "full": [398]}}, "Transport of bile salts and organic acids metal ions and amine compounds": {"direction": "up", "overlap": {"value": 4, "mean": 1.8349514563106797, "std": 1.258733277411433, "bin": {"bin_hit": 1, "bin_50": 0, "bin_100": 0, "bin_250": 2, "bin_500": 5}}, "setsize": {"value": 5, "mean": 3.995145631067961, "std": 1.3329199016551914, "bin": {"bin_hit": 32, "bin_50": 32, "bin_100": 32, "bin_250": 32, "bin_500": 32}}, "score": {"value": 2.364111264267477, "mean": 1.0286208624357371, "std": 1.161382969627279, "bin": {"bin_hit": 2.8438030560271645, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 2.699047619047619, "bin_500": 3.648261295919137}}, "pval": {"value": 0.0180733836813176, "mean": 0.2748571167414633, "std": 0.2758406238802445, "bin": {"bin_hit": 0.3047840834515223, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.181169408752189, "bin_500": 0.0181161163925661}}, "signature_idxs": {"edge": [256, 289, 169, 105], "full": [317, 169, 256, 105, 289]}}, "Vitamin b1 thiamin metabolism": {"direction": "up", "overlap": {"value": 0, "mean": 0.3830409356725146, "std": 0.5320753734224442, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.1169590643274854, "std": 0.321371500913078, "bin": {"bin_hit": 5, "bin_50": 5, "bin_100": 5, "bin_250": 5, "bin_500": 5}}, "score": {"value": 2.359214378391997, "mean": 0.8276438058867299, "std": 1.856316597453883, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 4.8969696969696965}}, "pval": {"value": 0.0183136726719275, "mean": 0.2237516804359743, "std": 0.2773217050898789, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.2207303711304172}}, "signature_idxs": {"edge": [], "full": [405]}}, "Cholesterol biosynthesis": {"direction": "up", "overlap": {"value": 9, "mean": 5.878640776699029, "std": 2.503362805703168, "bin": {"bin_hit": 2, "bin_50": 1, "bin_100": 2, "bin_250": 7, "bin_500": 10}}, "setsize": {"value": 18, "mean": 16.75, "std": 1.8986773628384943, "bin": {"bin_hit": 24, "bin_50": 24, "bin_100": 24, "bin_250": 24, "bin_500": 24}}, "score": {"value": 2.3571251547698284, "mean": 1.3996798653689082, "std": 1.0886216368414, "bin": {"bin_hit": 8.09251810136766, "bin_50": 9.170289855072465, "bin_100": 9.541666666666666, "bin_250": 17.04019607843137, "bin_500": 14.235743680188124}}, "pval": {"value": 0.018417038554944, "mean": 0.2350718901934974, "std": 0.270950573691616, "bin": {"bin_hit": 0.0296124183576188, "bin_50": 0.1093006244161378, "bin_100": 0.0219975904219434, "bin_250": 1.0946556618648063e-06, "bin_500": 7.181801758617746e-08}}, "signature_idxs": {"edge": [224, 226, 35, 294, 370, 147, 245, 63, 158], "full": [224, 245, 2401, 581, 226, 2746, 2825, 2913, 403, 147, 294, 2874, 63, 921, 35, 158, 1828, 370]}}, "Passive transport by aquaporins": {"direction": "up", "overlap": {"value": 0, "mean": 0.2065491183879093, "std": 0.4048290751429382, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_hit": 1, "bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "score": {"value": 2.352448961027142, "mean": 1.147839889154478, "std": 1.6711168772637148, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": Infinity}}, "pval": {"value": 0.0186502490596855, "mean": 0.2042509716132917, "std": 0.2414556156488147, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.0486465280492041}}, "signature_idxs": {"edge": [], "full": [411]}}, "Recruitment of mitotic centrosome proteins and complexes": {"direction": "up", "overlap": {"value": 20, "mean": 10.75485436893204, "std": 4.776113780352103, "bin": {"bin_hit": 1, "bin_50": 0, "bin_100": 0, "bin_250": 3, "bin_500": 9}}, "setsize": {"value": 32, "mean": 32.21116504854369, "std": 4.3238525164960775, "bin": {"bin_hit": 82, "bin_50": 82, "bin_100": 82, "bin_250": 82, "bin_500": 82}}, "score": {"value": 2.3473832286352687, "mean": 0.6690475765725821, "std": 1.0085704741220791, "bin": {"bin_hit": 1.0829542993285683, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 1.536107076156879, "bin_500": 2.4371466344125343}}, "pval": {"value": 0.0189057981846259, "mean": 0.4763419930316802, "std": 0.3559421309914655, "bin": {"bin_hit": 0.6069677113976195, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.3195580599455, "bin_500": 0.0177508820512533}}, "signature_idxs": {"edge": [639, 390, 401, 917, 290, 812, 813, 959, 576, 574, 439, 320, 585, 197, 583, 831, 741, 240, 118, 376], "full": [240, 290, 118, 390, 439, 401, 1063, 1995, 917, 1658, 583, 1107, 831, 2410, 1623, 1624, 320, 812, 813, 2274, 639, 1913, 585, 1916, 976, 376, 574, 741, 576, 2381, 959, 197]}}, "Ion channel transport": {"direction": "up", "overlap": {"value": 8, "mean": 9.031553398058252, "std": 4.2752930421976005, "bin": {"bin_hit": 3, "bin_50": 1, "bin_100": 3, "bin_250": 8, "bin_500": 10}}, "setsize": {"value": 26, "mean": 27.74271844660194, "std": 3.4432740668393595, "bin": {"bin_hit": 82, "bin_50": 82, "bin_100": 82, "bin_250": 82, "bin_500": 82}}, "score": {"value": 2.3464052805034834, "mean": 0.8980727715308076, "std": 1.4212023690700646, "bin": {"bin_hit": 3.3912748643761303, "bin_50": 2.588991769547325, "bin_100": 4.004930046635576, "bin_250": 4.46680990614045, "bin_500": 2.75148605395519}}, "pval": {"value": 0.0189554834858614, "mean": 0.3472480807052641, "std": 0.3452897078102002, "bin": {"bin_hit": 0.0652357572826681, "bin_50": 0.3274019772455256, "bin_100": 0.0442161560616649, "bin_250": 0.0008042937222718, "bin_500": 0.0062283989950113}}, "signature_idxs": {"edge": [230, 71, 138, 168, 137, 13, 87, 184], "full": [712, 2449, 300, 580, 1846, 2639, 137, 3043, 1617, 2864, 3156, 184, 2004, 466, 994, 1365, 714, 1668, 2273, 230, 138, 13, 87, 168, 1980, 71]}}, "Early phase of hiv life cycle": {"direction": "dw", "overlap": {"value": 6, "mean": 3.570388349514563, "std": 2.0138830879430665, "bin": {}}, "setsize": {"value": 9, "mean": 8.172330097087379, "std": 0.7286850823835631, "bin": {}}, "score": {"value": -2.3375483964825725, "mean": -0.7734676079712115, "std": 0.7892616290195563, "bin": {}}, "pval": {"value": 0.0194106875637163, "mean": 0.4167189976255093, "std": 0.2840468888898399, "bin": {}}, "signature_idxs": {"edge": [2638, 2955, 2888, 2820, 3163, 2721], "full": [2638, 2888, 1065, 1538, 2955, 887, 2820, 2721, 3163]}}, "Golgi to er retrograde transport": {"direction": "up", "overlap": {"value": 34, "mean": 16.92233009708738, "std": 7.275693434924061, "bin": {"bin_hit": 4, "bin_50": 4, "bin_100": 4, "bin_250": 7, "bin_500": 17}}, "setsize": {"value": 75, "mean": 70.53883495145631, "std": 5.280109829133333, "bin": {"bin_hit": 115, "bin_50": 115, "bin_100": 115, "bin_250": 115, "bin_500": 115}}, "score": {"value": 2.3329030513008537, "mean": 0.4559805501598206, "std": 0.9044409230983104, "bin": {"bin_hit": 3.236750263777291, "bin_50": 8.036836836836837, "bin_100": 3.828637147786084, "bin_250": 2.6576774691358023, "bin_500": 3.477355033871586}}, "pval": {"value": 0.0196532342036972, "mean": 0.6345143601474961, "std": 0.3556018909943214, "bin": {"bin_hit": 0.0408916108658733, "bin_50": 0.002200987019757, "bin_100": 0.0246695053344801, "bin_250": 0.0215851652574667, "bin_500": 3.788616181424059e-05}}, "signature_idxs": {"edge": [2, 259, 639, 390, 404, 657, 531, 29, 778, 30, 36, 417, 420, 812, 814, 813, 691, 577, 444, 710, 857, 320, 458, 583, 831, 596, 737, 612, 100, 231, 489, 500, 240, 378], "full": [1352, 1233, 2635, 259, 1101, 2304, 36, 1574, 240, 2312, 1535, 390, 1169, 2, 972, 990, 583, 2503, 2865, 1754, 1069, 417, 596, 2266, 2504, 2267, 2547, 831, 657, 531, 1624, 320, 2824, 458, 2152, 1511, 489, 778, 420, 812, 691, 813, 612, 639, 1913, 2325, 814, 3004, 29, 737, 500, 1679, 1118, 1215, 2759, 1927, 2780, 2168, 378, 404, 444, 2170, 1007, 1928, 961, 577, 880, 2295, 100, 1933, 231, 30, 857, 710, 1162]}}, "Anchoring of the basal body to the plasma membrane": {"direction": "up", "overlap": {"value": 16, "mean": 10.25, "std": 4.597184131808032, "bin": {"bin_hit": 1, "bin_50": 0, "bin_100": 0, "bin_250": 3, "bin_500": 9}}, "setsize": {"value": 30, "mean": 32.03398058252427, "std": 4.443147956867209, "bin": {"bin_hit": 95, "bin_50": 95, "bin_100": 95, "bin_250": 95, "bin_500": 95}}, "score": {"value": 2.3168565807812835, "mean": 0.6177589631738116, "std": 0.9752582334781768, "bin": {"bin_hit": 0.9319708846584548, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 1.3173111190306486, "bin_500": 2.065947184948188}}, "pval": {"value": 0.0205115456515658, "mean": 0.4929072994149106, "std": 0.3486333170600847, "bin": {"bin_hit": 0.6612910087646113, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.4056520117766984, "bin_500": 0.0411573249463058}}, "signature_idxs": {"edge": [290, 320, 585, 197, 639, 812, 813, 390, 692, 583, 240, 401, 118, 376, 574, 439], "full": [240, 290, 118, 390, 439, 401, 1063, 917, 1658, 583, 1107, 1901, 831, 2410, 1623, 1624, 320, 812, 813, 2274, 639, 1913, 692, 585, 1916, 976, 376, 574, 2381, 197]}}, "Fatty acid metabolism": {"direction": "dw", "overlap": {"value": 13, "mean": 12.601941747572816, "std": 6.622394788478767, "bin": {}}, "setsize": {"value": 59, "mean": 56.89320388349515, "std": 4.797678689021568, "bin": {}}, "score": {"value": -2.31072637457333, "mean": -0.6410370109047604, "std": 1.3258270224785833, "bin": {}}, "pval": {"value": 0.0208479734738751, "mean": 0.354277511640737, "std": 0.3264233172937892, "bin": {}}, "signature_idxs": {"edge": [3113, 3176, 3178, 3184, 3185, 3055, 2979, 3190, 3191, 2975, 3164, 3000, 2927], "full": [429, 389, 3164, 360, 966, 162, 505, 1985, 2927, 1750, 374, 3178, 1031, 3184, 1789, 3055, 3185, 1357, 2640, 4, 3176, 1579, 888, 3113, 1618, 2191, 3000, 1401, 391, 1853, 19, 130, 1324, 730, 1455, 2616, 2102, 3190, 2873, 421, 176, 2467, 923, 924, 236, 2015, 307, 2975, 3191, 322, 427, 2126, 347, 524, 1697, 2979, 215, 539, 1020]}}, "Transport of vitamins nucleosides and related molecules": {"direction": "up", "overlap": {"value": 4, "mean": 3.2985436893203883, "std": 1.766928610360549, "bin": {"bin_hit": 1, "bin_50": 0, "bin_100": 0, "bin_250": 2, "bin_500": 5}}, "setsize": {"value": 7, "mean": 7.703883495145631, "std": 0.9135891377639136, "bin": {"bin_hit": 21, "bin_50": 21, "bin_100": 21, "bin_250": 21, "bin_500": 21}}, "score": {"value": 2.308648881956975, "mean": 0.5884630304197642, "std": 1.2550983698791685, "bin": {"bin_hit": 4.412719298245614, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 4.266380236305048, "bin_500": 6.163441955193482}}, "pval": {"value": 0.0209630730841103, "mean": 0.3368828823659784, "std": 0.3076045725047946, "bin": {"bin_hit": 0.2121430514291059, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.090818300458346, "bin_500": 0.0028394369313259}}, "signature_idxs": {"edge": [321, 338, 217, 101], "full": [361, 338, 217, 1659, 954, 101, 321]}}, "Sphingolipid de novo biosynthesis": {"direction": "up", "overlap": {"value": 4, "mean": 4.08252427184466, "std": 1.939118365602947, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 4, "bin_500": 5}}, "setsize": {"value": 9, "mean": 10.614077669902912, "std": 1.3614298144224892, "bin": {"bin_hit": 29, "bin_50": 29, "bin_100": 29, "bin_250": 29, "bin_500": 29}}, "score": {"value": 2.3047469462530303, "mean": 1.3205451179619188, "std": 1.289169434780902, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 6.534320987654321, "bin_500": 4.105566870332654}}, "pval": {"value": 0.0211807499721354, "mean": 0.2079933246203462, "std": 0.261809046515659, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0049571663496986, "bin_500": 0.012033886898071}}, "signature_idxs": {"edge": [130, 99, 171, 159], "full": [303, 1060, 2496, 171, 1847, 130, 99, 159, 2256]}}, "Peptide hormone metabolism": {"direction": "up", "overlap": {"value": 4, "mean": 4.021844660194175, "std": 2.4979619838894513, "bin": {"bin_hit": 1, "bin_50": 0, "bin_100": 0, "bin_250": 3, "bin_500": 3}}, "setsize": {"value": 13, "mean": 14.021844660194176, "std": 2.4069092486442756, "bin": {"bin_hit": 43, "bin_50": 43, "bin_100": 43, "bin_250": 43, "bin_500": 43}}, "score": {"value": 2.297316315945484, "mean": 0.5560275504881529, "std": 0.8833525414026219, "bin": {"bin_hit": 2.096700083542189, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 3.045799180327869, "bin_500": 1.4695740365111565}}, "pval": {"value": 0.0216007317024198, "mean": 0.5205961274891826, "std": 0.3339695456705046, "bin": {"bin_hit": 0.3866153803858851, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0854582473740603, "bin_500": 0.3487517012854798}}, "signature_idxs": {"edge": [518, 105, 244, 172], "full": [1314, 972, 1502, 1544, 172, 533, 1418, 105, 518, 787, 1969, 1150, 244]}}, "Branched chain amino acid catabolism": {"direction": "dw", "overlap": {"value": 10, "mean": 6.08252427184466, "std": 3.186437496533361, "bin": {}}, "setsize": {"value": 14, "mean": 14.315533980582524, "std": 1.6743210350637572, "bin": {}}, "score": {"value": -2.290860366777719, "mean": -1.2246640404472435, "std": 1.1617003226674978, "bin": {}}, "pval": {"value": 0.0219714908773376, "mean": 0.2546113317180097, "std": 0.2762513209904451, "bin": {}}, "signature_idxs": {"edge": [2606, 2517, 3112, 3176, 2984, 2986, 2814, 3188, 3008, 2495], "full": [2495, 1032, 2606, 3112, 2814, 3176, 2984, 288, 2986, 482, 2517, 3188, 3008, 1388]}}, "Mecp2 regulates transcription factors": {"direction": "dw", "overlap": {"value": 1, "mean": 0.7543859649122807, "std": 0.4419421268812122, "bin": {}}, "setsize": {"value": 1, "mean": 1.0651629072681703, "std": 0.2468130928142392, "bin": {}}, "score": {"value": -2.2872163445403277, "mean": -0.9821656353327018, "std": 1.662506185432635, "bin": {}}, "pval": {"value": 0.0221831984730522, "mean": 0.2451761292150782, "std": 0.2750147578827311, "bin": {}}, "signature_idxs": {"edge": [2744], "full": [2744]}}, "Loss of mecp2 binding ability to the ncor smrt complex": {"direction": "dw", "overlap": {"value": 1, "mean": 1.075187969924812, "std": 0.689601172198382, "bin": {}}, "setsize": {"value": 1, "mean": 1.681704260651629, "std": 0.7090118809831967, "bin": {}}, "score": {"value": -2.2872163445403277, "mean": -0.809097629755611, "std": 1.4433389297374593, "bin": {}}, "pval": {"value": 0.0221831984730522, "mean": 0.3811620397087941, "std": 0.3388550575420108, "bin": {}}, "signature_idxs": {"edge": [2744], "full": [2744]}}, "Activation of caspases through apoptosome mediated cleavage": {"direction": "dw", "overlap": {"value": 1, "mean": 0.8250950570342205, "std": 0.7136751468972147, "bin": {}}, "setsize": {"value": 1, "mean": 1.726235741444867, "std": 0.8370893201906843, "bin": {}}, "score": {"value": -2.283792829653025, "mean": -0.0450006892733149, "std": 1.6275939148259246, "bin": {}}, "pval": {"value": 0.0223837092805885, "mean": 0.3588590179473497, "std": 0.3210554438575041, "bin": {}}, "signature_idxs": {"edge": [2742], "full": [2742]}}, "Gluconeogenesis": {"direction": "dw", "overlap": {"value": 8, "mean": 9.218446601941748, "std": 3.510158560654355, "bin": {}}, "setsize": {"value": 19, "mean": 19.468446601941743, "std": 0.7216987205649962, "bin": {}}, "score": {"value": -2.283579194996853, "mean": -1.235335626753432, "std": 1.0340807870828872, "bin": {}}, "pval": {"value": 0.02239627365141, "mean": 0.2983307929100476, "std": 0.3036335951310053, "bin": {}}, "signature_idxs": {"edge": [3105, 3174, 3143, 3147, 3181, 3084, 3133, 2995], "full": [527, 3084, 2995, 3143, 2576, 3105, 1613, 3133, 3181, 2355, 2578, 2768, 3147, 730, 3174, 870, 2367, 54, 428]}}, "Mitochondrial fatty acid beta oxidation of saturated fatty acids": {"direction": "dw", "overlap": {"value": 3, "mean": 2.5825242718446604, "std": 1.6415377105738755, "bin": {}}, "setsize": {"value": 7, "mean": 6.432038834951456, "std": 0.6629902241562827, "bin": {}}, "score": {"value": -2.274916212141979, "mean": -0.5688919684805643, "std": 1.176662695046664, "bin": {}}, "pval": {"value": 0.0229109566119336, "mean": 0.3517927368278176, "std": 0.2850504822779858, "bin": {}}, "signature_idxs": {"edge": [3176, 3055, 3191], "full": [3055, 3176, 1618, 391, 2616, 923, 3191]}}, "Assembly and cell surface presentation of nmda receptors": {"direction": "up", "overlap": {"value": 8, "mean": 4.021844660194175, "std": 2.466672711798564, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 6}}, "setsize": {"value": 13, "mean": 10.050970873786408, "std": 1.7830986526204615, "bin": {"bin_hit": 28, "bin_50": 28, "bin_100": 28, "bin_250": 28, "bin_500": 28}}, "score": {"value": 2.2664613333981736, "mean": 0.6119431771279947, "std": 1.029606868598912, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 5.386641929499072}}, "pval": {"value": 0.0234231520128513, "mean": 0.4638365400303644, "std": 0.3372268056856337, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.0019380906235741}}, "signature_idxs": {"edge": [612, 479, 320, 638, 390, 404, 279, 378], "full": [1491, 390, 479, 320, 279, 691, 1668, 2273, 612, 638, 2157, 378, 404]}}, "Diseases of glycosylation": {"direction": "up", "overlap": {"value": 8, "mean": 6.359223300970874, "std": 2.4657040544471793, "bin": {"bin_hit": 2, "bin_50": 1, "bin_100": 2, "bin_250": 4, "bin_500": 9}}, "setsize": {"value": 19, "mean": 19.17718446601942, "std": 2.991113672999948, "bin": {"bin_hit": 76, "bin_50": 76, "bin_100": 76, "bin_250": 76, "bin_500": 76}}, "score": {"value": 2.2571358221410867, "mean": 0.13180823173309, "std": 1.5111068586159069, "bin": {"bin_hit": 2.393446543889022, "bin_50": 2.7977777777777777, "bin_100": 2.822072072072072, "bin_250": 2.25811614083219, "bin_500": 2.657053541328266}}, "pval": {"value": 0.0239995891128643, "mean": 0.3045208720095976, "std": 0.284004628008759, "bin": {"bin_hit": 0.2113863983482243, "bin_50": 0.3075216202298709, "bin_100": 0.1656331484196294, "bin_250": 0.1123101919918835, "bin_500": 0.0111310072807516}}, "signature_idxs": {"edge": [291, 199, 293, 11, 275, 82, 316, 127], "full": [3012, 275, 1166, 1355, 293, 726, 127, 11, 2817, 2612, 2911, 1909, 517, 2852, 326, 82, 291, 316, 199]}}, "Digestion": {"direction": "up", "overlap": {"value": 0, "mean": 0.3442211055276382, "std": 0.475113603296063, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_hit": 1, "bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "score": {"value": 2.2454828509260683, "mean": 0.6962697927632293, "std": 1.93348504508116, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": Infinity}}, "pval": {"value": 0.0247371519356409, "mean": 0.2228430358983308, "std": 0.2739052325555903, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.0486465280492041}}, "signature_idxs": {"edge": [], "full": [461]}}, "Digestion and absorption": {"direction": "up", "overlap": {"value": 0, "mean": 0.3442211055276382, "std": 0.475113603296063, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_hit": 1, "bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "score": {"value": 2.2454828509260683, "mean": 0.6962697927632293, "std": 1.93348504508116, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": Infinity}}, "pval": {"value": 0.0247371519356409, "mean": 0.2228430358983308, "std": 0.2739052325555903, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.0486465280492041}}, "signature_idxs": {"edge": [], "full": [461]}}, "Rna polymerase i transcription": {"direction": "dw", "overlap": {"value": 11, "mean": 10.388349514563108, "std": 4.581480257904396, "bin": {}}, "setsize": {"value": 24, "mean": 24.262135922330096, "std": 2.8826941452265062, "bin": {}}, "score": {"value": -2.2446759116564454, "mean": -0.9309058146249278, "std": 0.8892399654699277, "bin": {}}, "pval": {"value": 0.0247889455286105, "mean": 0.4158980874230077, "std": 0.3326903930342584, "bin": {}}, "signature_idxs": {"edge": [2834, 2445, 3109, 2562, 2699, 3015, 2566, 3060, 2478, 2892, 2863], "full": [2445, 3109, 1987, 1707, 3015, 2863, 2091, 569, 1135, 916, 2892, 1071, 3060, 2051, 1460, 1629, 1079, 1369, 2478, 2834, 2699, 2562, 2566, 2123]}}, "Signaling by tgf beta receptor complex in cancer": {"direction": "up", "overlap": {"value": 0, "mean": 0.3025477707006369, "std": 0.4928080264186791, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.1210191082802548, "std": 0.3261494806240027, "bin": {"bin_hit": 8, "bin_50": 8, "bin_100": 8, "bin_250": 8, "bin_500": 8}}, "score": {"value": 2.236961177799324, "mean": 1.0713765416485823, "std": 1.9560115823637287, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 2.7974025974025976}}, "pval": {"value": 0.0252888774899084, "mean": 0.1610371989586262, "std": 0.2386021436068951, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.3290745839784397}}, "signature_idxs": {"edge": [], "full": [481]}}, "Glycerophospholipid biosynthesis": {"direction": "up", "overlap": {"value": 13, "mean": 9.439320388349516, "std": 4.809346434845489, "bin": {"bin_hit": 3, "bin_50": 0, "bin_100": 1, "bin_250": 4, "bin_500": 11}}, "setsize": {"value": 29, "mean": 29.58009708737864, "std": 4.094857299253986, "bin": {"bin_hit": 86, "bin_50": 86, "bin_100": 86, "bin_250": 86, "bin_500": 86}}, "score": {"value": 2.229733442186519, "mean": 1.1800609247564997, "std": 1.3402414818469337, "bin": {"bin_hit": 3.2265490533562824, "bin_50": 0.0, "bin_100": 1.2144329896907216, "bin_250": 1.9807286961758503, "bin_500": 2.910652920962199}}, "pval": {"value": 0.0257651443353694, "mean": 0.3081196451067344, "std": 0.3224557628717913, "bin": {"bin_hit": 0.0730345043841296, "bin_50": 1.0, "bin_100": 0.5657328567415809, "bin_250": 0.1553404749607282, "bin_500": 0.002896721501077}}, "signature_idxs": {"edge": [262, 492, 415, 682, 578, 208, 107, 80, 340, 343, 123, 385, 318], "full": [578, 2308, 415, 2036, 1399, 340, 1618, 1660, 1285, 1241, 2616, 2048, 1295, 385, 492, 262, 123, 2855, 1174, 80, 318, 343, 2564, 3142, 1429, 208, 107, 680, 682]}}, "Activation of nmda receptors and postsynaptic events": {"direction": "up", "overlap": {"value": 13, "mean": 6.531553398058253, "std": 3.686958716509548, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 8}}, "setsize": {"value": 25, "mean": 22.640776699029125, "std": 3.4007548246413095, "bin": {"bin_hit": 68, "bin_50": 68, "bin_100": 68, "bin_250": 68, "bin_500": 68}}, "score": {"value": 2.2216216370706583, "mean": 0.202717901626862, "std": 0.9825513888915872, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.5995631598107026, "bin_500": 2.633879781420765}}, "pval": {"value": 0.0263088863699474, "mean": 0.5678584679324417, "std": 0.3302803464124077, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.8123479471098708, "bin_500": 0.0168669379700177}}, "signature_idxs": {"edge": [612, 320, 479, 543, 225, 638, 390, 538, 333, 404, 691, 279, 378], "full": [1491, 390, 479, 225, 2141, 2892, 1136, 1658, 755, 1140, 333, 543, 320, 279, 691, 1668, 2273, 612, 951, 638, 2157, 953, 378, 404, 538]}}, "Sumoylation": {"direction": "dw", "overlap": {"value": 37, "mean": 27.97087378640777, "std": 10.455134206471588, "bin": {}}, "setsize": {"value": 75, "mean": 75.44902912621359, "std": 6.947432579432031, "bin": {}}, "score": {"value": -2.2042015421980183, "mean": -0.8502599577556972, "std": 1.023857262091053, "bin": {}}, "pval": {"value": 0.0275101733744742, "mean": 0.4911906171274051, "std": 0.3427115261701629, "bin": {}}, "signature_idxs": {"edge": [2400, 2544, 2545, 2826, 2676, 2216, 2200, 2201, 2219, 3098, 2574, 2713, 2187, 2850, 2580, 2844, 2716, 3002, 2454, 2239, 2220, 2221, 3023, 3018, 2366, 2778, 2779, 2897, 2664, 2498, 3163, 2921, 2173, 3046, 2699, 3060, 2140], "full": [2220, 1315, 2221, 2574, 2140, 2400, 2498, 2040, 2187, 2713, 2676, 1614, 2716, 1655, 2454, 1359, 2544, 3018, 2580, 2545, 2844, 2002, 1757, 1402, 1899, 440, 1800, 1073, 3060, 3002, 2850, 2239, 623, 2897, 1912, 1629, 2200, 3163, 1079, 2826, 2201, 2366, 782, 3046, 1588, 1730, 586, 957, 1002, 1419, 1865, 1556, 676, 2699, 2778, 1924, 1768, 1822, 1823, 2779, 3098, 845, 95, 3023, 1827, 2216, 2173, 1125, 2921, 2129, 1436, 2664, 1229, 2219, 1232]}}, "Integration of provirus": {"direction": "dw", "overlap": {"value": 5, "mean": 2.796116504854369, "std": 1.712938900179165, "bin": {}}, "setsize": {"value": 7, "mean": 6.298543689320389, "std": 0.5917702712341049, "bin": {}}, "score": {"value": -2.196832189786761, "mean": -0.7031229294436337, "std": 0.8110987775231795, "bin": {}}, "pval": {"value": 0.0280324332009875, "mean": 0.4357474252630402, "std": 0.2902197277452994, "bin": {}}, "signature_idxs": {"edge": [2638, 2955, 2888, 3163, 2721], "full": [2638, 2888, 1065, 1538, 2955, 2721, 3163]}}, "Metabolism of porphyrins": {"direction": "up", "overlap": {"value": 3, "mean": 2.766990291262136, "std": 1.3861582272503026, "bin": {"bin_hit": 2, "bin_50": 1, "bin_100": 2, "bin_250": 3, "bin_500": 4}}, "setsize": {"value": 10, "mean": 9.186893203883496, "std": 1.170645435718008, "bin": {"bin_hit": 17, "bin_50": 17, "bin_100": 17, "bin_250": 17, "bin_500": 17}}, "score": {"value": 2.188740355143026, "mean": 1.2638611374915407, "std": 1.0950295956895657, "bin": {"bin_hit": 11.877286135693216, "bin_50": 13.19140625, "bin_100": 14.004166666666666, "bin_250": 8.725117096018735, "bin_500": 6.058161350844277}}, "pval": {"value": 0.0286157170722165, "mean": 0.2204767139400954, "std": 0.2541910601955712, "bin": {"bin_hit": 0.0153567023685368, "bin_50": 0.0786913117950012, "bin_100": 0.0113213926532688, "bin_250": 0.0074273483269255, "bin_500": 0.0079370796506279}}, "signature_idxs": {"edge": [17, 69, 150], "full": [2840, 886, 17, 260, 69, 888, 1450, 2614, 1246, 150]}}, "Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane": {"direction": "up", "overlap": {"value": 3, "mean": 2.2694174757281553, "std": 1.21588860409113, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 4}}, "setsize": {"value": 5, "mean": 4.735436893203883, "std": 0.4465689624800877, "bin": {"bin_hit": 8, "bin_50": 8, "bin_100": 8, "bin_250": 8, "bin_500": 8}}, "score": {"value": 2.186417656748226, "mean": 0.3669027527063505, "std": 1.1543527848059545, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 5.7735191637630665, "bin_500": 19.70731707317073}}, "pval": {"value": 0.0287850629833763, "mean": 0.3957232167693734, "std": 0.3128036344848447, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1781979724676324, "bin_500": 0.0003311660608568}}, "signature_idxs": {"edge": [321, 338, 217], "full": [361, 338, 217, 1659, 321]}}, "Cargo concentration in the er": {"direction": "up", "overlap": {"value": 6, "mean": 4.813106796116505, "std": 2.4168749497181627, "bin": {"bin_hit": 1, "bin_50": 1, "bin_100": 1, "bin_250": 2, "bin_500": 7}}, "setsize": {"value": 16, "mean": 14.480582524271844, "std": 1.7521447745979526, "bin": {"bin_hit": 23, "bin_50": 23, "bin_100": 23, "bin_250": 23, "bin_500": 23}}, "score": {"value": 2.1834765971931303, "mean": 0.5034715777808771, "std": 1.0073939692365603, "bin": {"bin_hit": 4.010765550239235, "bin_50": 9.588068181818182, "bin_100": 4.721649484536083, "bin_250": 3.859280855199223, "bin_500": 8.664110429447852}}, "pval": {"value": 0.0290007305593329, "mean": 0.4707340910089172, "std": 0.3173017432503084, "bin": {"bin_hit": 0.2298523273424841, "bin_50": 0.1049896535105009, "bin_100": 0.1993869387044997, "bin_250": 0.1060727287920157, "bin_500": 7.666164058302006e-05}}, "signature_idxs": {"edge": [354, 490, 417, 244, 29, 386], "full": [798, 1574, 1194, 942, 867, 417, 487, 2321, 490, 354, 29, 998, 1172, 386, 744, 244]}}, "Synthesis of pa": {"direction": "up", "overlap": {"value": 7, "mean": 2.9635922330097086, "std": 1.9473992387004595, "bin": {"bin_hit": 2, "bin_50": 0, "bin_100": 0, "bin_250": 3, "bin_500": 6}}, "setsize": {"value": 11, "mean": 8.558252427184467, "std": 1.904008254033093, "bin": {"bin_hit": 25, "bin_50": 25, "bin_100": 25, "bin_250": 25, "bin_500": 25}}, "score": {"value": 2.175402030097835, "mean": 0.9129149199765416, "std": 1.1909456358572703, "bin": {"bin_hit": 7.739899961523663, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 5.547876304023845, "bin_500": 6.239097744360902}}, "pval": {"value": 0.0296000025140863, "mean": 0.2964837496518883, "std": 0.2923824193190221, "bin": {"bin_hit": 0.0319541253073341, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0217985290060267, "bin_500": 0.0010313331646429}}, "signature_idxs": {"edge": [492, 107, 578, 208, 123, 385, 318], "full": [578, 1660, 385, 492, 123, 2855, 1174, 318, 208, 107, 682]}}, "Ercc6 csb and ehmt2 g9a positively regulate rrna expression": {"direction": "dw", "overlap": {"value": 7, "mean": 6.007281553398058, "std": 2.9233650958842756, "bin": {}}, "setsize": {"value": 13, "mean": 12.45631067961165, "std": 1.421244491098621, "bin": {}}, "score": {"value": -2.1746200038103605, "mean": -0.8896070493117743, "std": 0.8959073330962924, "bin": {}}, "pval": {"value": 0.0296586040341653, "mean": 0.3866497917243187, "std": 0.3113893370014395, "bin": {}}, "signature_idxs": {"edge": [2834, 2562, 2699, 3015, 3060, 2478, 2863], "full": [1987, 3015, 2863, 3060, 2051, 1460, 1629, 1079, 1369, 2478, 2834, 2699, 2562]}}, "Cilium assembly": {"direction": "up", "overlap": {"value": 27, "mean": 17.691747572815533, "std": 8.208427462797529, "bin": {"bin_hit": 2, "bin_50": 1, "bin_100": 1, "bin_250": 4, "bin_500": 13}}, "setsize": {"value": 60, "mean": 60.07281553398058, "std": 7.176657065505861, "bin": {"bin_hit": 183, "bin_50": 183, "bin_100": 183, "bin_250": 183, "bin_500": 183}}, "score": {"value": 2.169709073383836, "mean": 0.7163847705434252, "std": 1.1196611241046792, "bin": {"bin_hit": 0.9680731433041608, "bin_50": 1.1406822344322345, "bin_100": 0.5616857369434689, "bin_250": 0.8984527668574844, "bin_500": 1.508829618804043}}, "pval": {"value": 0.0300288922601434, "mean": 0.5030560453085753, "std": 0.3669144822823486, "bin": {"bin_hit": 0.6151440919768146, "bin_50": 0.5891657340012217, "bin_100": 0.8319470589363818, "bin_250": 0.6515678928767983, "bin_500": 0.1097939825183114}}, "signature_idxs": {"edge": [787, 518, 9, 639, 390, 271, 401, 404, 290, 812, 813, 692, 691, 574, 439, 857, 320, 585, 197, 842, 583, 612, 240, 118, 497, 376, 378], "full": [271, 9, 1314, 1495, 240, 290, 118, 390, 439, 401, 1063, 1993, 1169, 917, 1658, 2406, 583, 2866, 2317, 2968, 2098, 1107, 1901, 831, 2410, 1623, 1624, 320, 1459, 497, 812, 691, 813, 612, 2274, 639, 1913, 692, 585, 1916, 976, 376, 1418, 842, 518, 1215, 931, 787, 574, 2597, 2759, 1150, 2381, 378, 404, 3089, 197, 1156, 857, 1271]}}, "Phospholipid metabolism": {"direction": "up", "overlap": {"value": 19, "mean": 12.859223300970871, "std": 6.241466981115118, "bin": {"bin_hit": 3, "bin_50": 0, "bin_100": 1, "bin_250": 4, "bin_500": 12}}, "setsize": {"value": 46, "mean": 45.932038834951456, "std": 7.362344677079641, "bin": {"bin_hit": 156, "bin_50": 156, "bin_100": 156, "bin_250": 156, "bin_500": 156}}, "score": {"value": 2.166514407483393, "mean": 1.017004520648936, "std": 1.3242274243570669, "bin": {"bin_hit": 1.738095238095238, "bin_50": 0.0, "bin_100": 0.6613235783172597, "bin_250": 1.0609703270521984, "bin_500": 1.6453168044077136}}, "pval": {"value": 0.0302719001116154, "mean": 0.3949296504793965, "std": 0.3709328103546776, "bin": {"bin_hit": 0.2576682789514687, "bin_50": 1.0, "bin_100": 0.7809139112323245, "bin_250": 0.5254118064426402, "bin_500": 0.0777917519036925}}, "signature_idxs": {"edge": [262, 665, 682, 680, 415, 318, 578, 208, 80, 340, 343, 350, 492, 107, 497, 641, 123, 385, 645], "full": [350, 1490, 578, 2636, 2308, 415, 2036, 1399, 989, 1945, 340, 1618, 1660, 1285, 1241, 2616, 1247, 2048, 1906, 690, 497, 1295, 385, 492, 262, 1732, 123, 2855, 1174, 80, 318, 665, 343, 2563, 1523, 2564, 641, 3142, 1429, 2386, 208, 107, 680, 645, 682, 1602]}}, "Heparan sulfate heparin hs gag metabolism": {"direction": "up", "overlap": {"value": 3, "mean": 2.4320388349514563, "std": 1.2648123228701085, "bin": {"bin_hit": 1, "bin_50": 1, "bin_100": 1, "bin_250": 3, "bin_500": 4}}, "setsize": {"value": 4, "mean": 4.83252427184466, "std": 1.2708877857521428, "bin": {"bin_hit": 32, "bin_50": 32, "bin_100": 32, "bin_250": 32, "bin_500": 32}}, "score": {"value": 2.163576076654026, "mean": 0.8003221575390526, "std": 1.4628061886044337, "bin": {"bin_hit": 2.8438030560271645, "bin_50": 6.798387096774194, "bin_100": 3.3478550049883604, "bin_250": 4.205765969474279, "bin_500": 2.808362369337979}}, "pval": {"value": 0.0304968992286172, "mean": 0.2230961855611341, "std": 0.2633127679646707, "bin": {"bin_hit": 0.3047840834515223, "bin_50": 0.1430638950507344, "bin_100": 0.266209970857853, "bin_250": 0.0415700360883472, "bin_500": 0.0678374957909117}}, "signature_idxs": {"edge": [11, 131, 166], "full": [11, 166, 131, 291]}}, "Transport of mature transcript to cytoplasm": {"direction": "dw", "overlap": {"value": 24, "mean": 22.179611650485437, "std": 9.223322687761865, "bin": {}}, "setsize": {"value": 62, "mean": 63.12378640776699, "std": 3.3978458671491603, "bin": {}}, "score": {"value": -2.1631502150581325, "mean": -0.6291260216114811, "std": 1.0645020276827344, "bin": {}}, "pval": {"value": 0.0305296279501245, "mean": 0.5624135506222746, "std": 0.342276085943197, "bin": {}}, "signature_idxs": {"edge": [2407, 2544, 2411, 2958, 2549, 2950, 2725, 2574, 2851, 2585, 2755, 2880, 2877, 3002, 2465, 2619, 2872, 3023, 2664, 3036, 2667, 2436, 2787, 2696], "full": [2950, 1315, 1609, 2787, 2574, 1614, 1321, 1359, 2544, 2407, 2002, 1757, 1402, 440, 1800, 3002, 1109, 2006, 2411, 2725, 1077, 2585, 2851, 2549, 623, 2324, 2872, 2619, 1724, 2465, 2060, 1588, 2877, 1730, 3036, 2755, 2696, 586, 1002, 1419, 2958, 1865, 1556, 1176, 676, 2019, 1924, 1968, 2880, 845, 95, 3023, 1827, 1526, 2436, 2173, 1875, 646, 1392, 2664, 2667, 1647]}}, "Heme degradation": {"direction": "up", "overlap": {"value": 1, "mean": 1.2936893203883495, "std": 0.7198024139502899, "bin": {"bin_hit": 2, "bin_50": 1, "bin_100": 2, "bin_250": 2, "bin_500": 2}}, "setsize": {"value": 4, "mean": 3.888349514563106, "std": 0.613093535820443, "bin": {"bin_hit": 7, "bin_50": 7, "bin_100": 7, "bin_250": 7, "bin_500": 7}}, "score": {"value": 2.154738265511408, "mean": 1.3644540792548048, "std": 1.150391861359729, "bin": {"bin_hit": 35.667256637168144, "bin_50": 35.21180555555556, "bin_100": 42.05416666666667, "bin_250": 16.235102040816326, "bin_500": 7.850202429149798}}, "pval": {"value": 0.0311823215918471, "mean": 0.1853348016647351, "std": 0.234811337893219, "bin": {"bin_hit": 0.0025522664083896, "bin_50": 0.0331691185540615, "bin_100": 0.0018609890552042, "bin_250": 0.0113265963942617, "bin_500": 0.042147958906207}}, "signature_idxs": {"edge": [17], "full": [17, 69, 888, 1246]}}, "Aurka activation by tpx2": {"direction": "up", "overlap": {"value": 12, "mean": 10.276699029126211, "std": 4.914920890107843, "bin": {"bin_hit": 1, "bin_50": 0, "bin_100": 0, "bin_250": 3, "bin_500": 9}}, "setsize": {"value": 30, "mean": 31.893203883495147, "std": 4.281168113347361, "bin": {"bin_hit": 73, "bin_50": 73, "bin_100": 73, "bin_250": 73, "bin_500": 73}}, "score": {"value": 2.1494652681090023, "mean": 0.5790832053921023, "std": 0.9784215516709706, "bin": {"bin_hit": 1.2194200779727096, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 1.735187353629977, "bin_500": 2.7824691991786445}}, "pval": {"value": 0.0315975364406053, "mean": 0.5039527741558584, "std": 0.3534896123548716, "bin": {"bin_hit": 0.5643843751416258, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.2599162900657007, "bin_500": 0.008617935758856}}, "signature_idxs": {"edge": [290, 320, 585, 197, 390, 583, 240, 401, 118, 376, 574, 439], "full": [2220, 240, 290, 118, 390, 439, 401, 1063, 917, 1658, 583, 1107, 831, 2410, 1623, 1624, 320, 812, 813, 2274, 639, 1913, 585, 1916, 976, 376, 574, 2381, 197, 1782]}}, "Rho gtpases activate pkns": {"direction": "dw", "overlap": {"value": 15, "mean": 6.701456310679611, "std": 3.8592591742852456, "bin": {}}, "setsize": {"value": 20, "mean": 19.070388349514563, "std": 1.6944789973574843, "bin": {}}, "score": {"value": -2.149313617662945, "mean": -0.6522259842150975, "std": 0.9170476614712676, "bin": {}}, "pval": {"value": 0.0316095477581941, "mean": 0.4949181272620779, "std": 0.336513671367134, "bin": {}}, "signature_idxs": {"edge": [2933, 2133, 3140, 2740, 2013, 2410, 1948, 1940, 2236, 2816, 3060, 2322, 2463, 2051, 2863], "full": [1023, 1940, 2863, 2933, 2816, 2740, 1948, 1449, 2322, 2410, 3140, 1623, 3060, 2236, 2051, 2463, 2013, 1550, 1000, 2133]}}, "Nr1h2 and nr1h3 mediated signaling": {"direction": "up", "overlap": {"value": 2, "mean": 1.7572815533980584, "std": 1.3326812116893596, "bin": {"bin_hit": 1, "bin_50": 0, "bin_100": 1, "bin_250": 2, "bin_500": 3}}, "setsize": {"value": 6, "mean": 5.883495145631068, "std": 1.0798325191407745, "bin": {"bin_hit": 31, "bin_50": 31, "bin_100": 31, "bin_250": 31, "bin_500": 31}}, "score": {"value": 2.145638902107472, "mean": 0.5602851963271924, "std": 0.9054264155985514, "bin": {"bin_hit": 2.938888888888889, "bin_50": 0.0, "bin_100": 3.45979381443299, "bin_250": 2.792399718508093, "bin_500": 2.1019994204578385}}, "pval": {"value": 0.0319017992032228, "mean": 0.4625468402768004, "std": 0.3047539501790259, "bin": {"bin_hit": 0.296828876454131, "bin_50": 1.0, "bin_100": 0.2590666885683055, "bin_250": 0.1724444479617574, "bin_500": 0.1897708582520546}}, "signature_idxs": {"edge": [78, 246], "full": [360, 1940, 1401, 78, 246, 1128]}}, "2 ltr circle formation": {"direction": "dw", "overlap": {"value": 4, "mean": 2.516990291262136, "std": 1.4370961382542755, "bin": {}}, "setsize": {"value": 6, "mean": 5.317961165048544, "std": 0.5646269654757307, "bin": {}}, "score": {"value": -2.144997224193387, "mean": -0.7460036474006798, "std": 0.8110523787380166, "bin": {}}, "pval": {"value": 0.0319530689270664, "mean": 0.4230772547046059, "std": 0.2878898717022174, "bin": {}}, "signature_idxs": {"edge": [3163, 2888, 2638, 2955], "full": [2638, 2888, 1065, 1538, 2955, 3163]}}, "Autophagy": {"direction": "up", "overlap": {"value": 18, "mean": 10.618932038834952, "std": 5.048592116085888, "bin": {"bin_hit": 3, "bin_50": 3, "bin_100": 3, "bin_250": 4, "bin_500": 12}}, "setsize": {"value": 47, "mean": 49.09466019417476, "std": 6.4120843612202885, "bin": {"bin_hit": 130, "bin_50": 130, "bin_100": 130, "bin_250": 130, "bin_500": 130}}, "score": {"value": 2.1274714330121336, "mean": 0.5991637048381673, "std": 0.9575127000026346, "bin": {"bin_hit": 2.0994094488188977, "bin_50": 5.145498117083191, "bin_100": 2.4793203481143804, "bin_250": 1.283297406754197, "bin_500": 2.0133071858803757}}, "pval": {"value": 0.0333809324346043, "mean": 0.5478738847433878, "std": 0.3634200031879806, "bin": {"bin_hit": 0.1810995559665352, "bin_50": 0.0243688794183964, "bin_100": 0.1295090696181635, "bin_250": 0.3867509927062335, "bin_500": 0.0243195599207254}}, "signature_idxs": {"edge": [548, 566, 588, 320, 543, 612, 7, 328, 41, 390, 204, 16, 471, 404, 409, 280, 378, 651], "full": [1101, 1131, 1316, 2735, 651, 390, 1063, 1195, 566, 2354, 204, 1399, 7, 409, 543, 2969, 2147, 1040, 1624, 2048, 320, 812, 691, 612, 1913, 838, 548, 280, 784, 471, 328, 41, 1966, 1052, 2759, 588, 1596, 3098, 1523, 2881, 378, 404, 1930, 16, 1691, 1606, 1162]}}, "Estrogen biosynthesis": {"direction": "up", "overlap": {"value": 0, "mean": 0.3772609819121447, "std": 0.4847010763747376, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_hit": 2, "bin_50": 2, "bin_100": 2, "bin_250": 2, "bin_500": 2}}, "score": {"value": 2.125769727469593, "mean": 0.4853706155859429, "std": 1.7208386185715674, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0335224378253722, "mean": 0.2595981981172538, "std": 0.264674537828635, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [550]}}, "Dopamine clearance from the synaptic cleft": {"direction": "up", "overlap": {"value": 0, "mean": 0.2087378640776699, "std": 0.4064066537077882, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_hit": 2, "bin_50": 2, "bin_100": 2, "bin_250": 2, "bin_500": 2}}, "score": {"value": 2.1137515440384504, "mean": 1.372670814021126, "std": 1.8450353888024225, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0345364935747876, "mean": 0.1400459461927921, "std": 0.2133773995485727, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [542]}}, "Keratan sulfate keratin metabolism": {"direction": "up", "overlap": {"value": 3, "mean": 3.1359223300970873, "std": 1.294488268568909, "bin": {"bin_hit": 1, "bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 4}}, "setsize": {"value": 5, "mean": 5.439320388349515, "std": 0.7592200419566036, "bin": {"bin_hit": 17, "bin_50": 17, "bin_100": 17, "bin_250": 17, "bin_500": 17}}, "score": {"value": 2.1122343402786994, "mean": 0.1148000450757159, "std": 1.8452752770630356, "bin": {"bin_hit": 5.5180921052631575, "bin_50": 13.19140625, "bin_100": 6.496134020618556, "bin_250": 2.523628048780488, "bin_500": 6.058161350844277}}, "pval": {"value": 0.034666354449226, "mean": 0.1857420338858874, "std": 0.2520366769461069, "bin": {"bin_hit": 0.175504593120769, "bin_50": 0.0786913117950012, "bin_100": 0.1515272625734178, "bin_250": 0.3411306657380243, "bin_500": 0.0079370796506279}}, "signature_idxs": {"edge": [293, 275, 11], "full": [275, 293, 726, 310, 11]}}, "Activation of ampk downstream of nmdars": {"direction": "up", "overlap": {"value": 6, "mean": 3.354368932038835, "std": 1.771033196282823, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 4}}, "setsize": {"value": 7, "mean": 6.451456310679611, "std": 1.4598419968812493, "bin": {"bin_hit": 21, "bin_50": 21, "bin_100": 21, "bin_250": 21, "bin_500": 21}}, "score": {"value": 2.1027498211311157, "mean": 0.5566970459139938, "std": 1.088746190595968, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 4.630798660927786}}, "pval": {"value": 0.0354876444670442, "mean": 0.4440483464816752, "std": 0.3283169353723064, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.0171177319456962}}, "signature_idxs": {"edge": [612, 320, 543, 390, 404, 378], "full": [390, 543, 320, 691, 612, 378, 404]}}, "Triglyceride catabolism": {"direction": "dw", "overlap": {"value": 2, "mean": 2.825242718446602, "std": 1.4509935294966527, "bin": {}}, "setsize": {"value": 4, "mean": 5.747572815533981, "std": 1.1339290452446105, "bin": {}}, "score": {"value": -2.0957088635262173, "mean": -0.7377640012455176, "std": 0.9450006225325472, "bin": {}}, "pval": {"value": 0.0361080251112442, "mean": 0.4259742833462081, "std": 0.3225564786765671, "bin": {}}, "signature_idxs": {"edge": [3140, 3096], "full": [1131, 1660, 3096, 3140]}}, "Signaling by tgf beta receptor complex": {"direction": "dw", "overlap": {"value": 8, "mean": 7.283980582524272, "std": 3.823082129708535, "bin": {}}, "setsize": {"value": 18, "mean": 19.645631067961165, "std": 2.909751822701447, "bin": {}}, "score": {"value": -2.09113044185081, "mean": -0.5415434619326152, "std": 0.9706726286053544, "bin": {}}, "pval": {"value": 0.0365163725125194, "mean": 0.4952747092906258, "std": 0.3226009862541514, "bin": {}}, "signature_idxs": {"edge": [3140, 2904, 2668, 3096, 2708, 2892, 2762, 3032], "full": [2261, 2040, 1500, 2892, 1136, 3032, 3096, 3140, 481, 1079, 1630, 1967, 2762, 1831, 2708, 647, 2668, 2904]}}, "Transport of connexons to the plasma membrane": {"direction": "up", "overlap": {"value": 5, "mean": 2.7063106796116503, "std": 1.3523295185638555, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 4}}, "setsize": {"value": 6, "mean": 4.587378640776699, "std": 0.9949561742458796, "bin": {"bin_hit": 14, "bin_50": 14, "bin_100": 14, "bin_250": 14, "bin_500": 14}}, "score": {"value": 2.0859163768023468, "mean": 0.4995785603281155, "std": 1.150433862709782, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 7.878048780487805}}, "pval": {"value": 0.0369861985579709, "mean": 0.4095483585324659, "std": 0.3070287716914409, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.0037486095651754}}, "signature_idxs": {"edge": [612, 320, 390, 404, 378], "full": [390, 320, 691, 612, 378, 404]}}, "Gap junction assembly": {"direction": "up", "overlap": {"value": 5, "mean": 2.7184466019417477, "std": 1.37358913126072, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 4}}, "setsize": {"value": 6, "mean": 4.604368932038835, "std": 1.0102774490620512, "bin": {"bin_hit": 15, "bin_50": 15, "bin_100": 15, "bin_250": 15, "bin_500": 15}}, "score": {"value": 2.0859163768023468, "mean": 0.499967666973865, "std": 1.1493312724073153, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 7.161123429416112}}, "pval": {"value": 0.0369861985579709, "mean": 0.4121155936503509, "std": 0.3091304616480874, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.0049176108076387}}, "signature_idxs": {"edge": [612, 320, 390, 404, 378], "full": [390, 320, 691, 612, 378, 404]}}, "Detoxification of reactive oxygen species": {"direction": "dw", "overlap": {"value": 4, "mean": 4.444174757281553, "std": 2.0560802675351155, "bin": {}}, "setsize": {"value": 9, "mean": 10.019417475728156, "std": 0.8270967180770472, "bin": {}}, "score": {"value": -2.0830966959756823, "mean": -0.6490446793765532, "std": 0.7836320322231982, "bin": {}}, "pval": {"value": 0.0372424104949735, "mean": 0.5063051671476146, "std": 0.3127465825202154, "bin": {}}, "signature_idxs": {"edge": [2966, 3154, 3029, 3144], "full": [751, 3144, 1652, 2609, 3154, 3029, 2966, 843, 1969]}}, "Retinoid cycle disease events": {"direction": "up", "overlap": {"value": 0, "mean": 0.2419354838709677, "std": 0.4282554208823145, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_hit": 2, "bin_50": 2, "bin_100": 2, "bin_250": 2, "bin_500": 2}}, "score": {"value": 2.0690421352232486, "mean": 1.3406886352746992, "std": 2.225926137907829, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0385421329334727, "mean": 0.0695157382945415, "std": 0.112629918572638, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [567]}}, "Diseases associated with n glycosylation of proteins": {"direction": "up", "overlap": {"value": 3, "mean": 2.2475728155339807, "std": 1.5924179977786468, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 3}}, "setsize": {"value": 5, "mean": 5.725728155339806, "std": 1.7320559095113808, "bin": {"bin_hit": 18, "bin_50": 18, "bin_100": 18, "bin_250": 18, "bin_500": 18}}, "score": {"value": 2.0564915799222656, "mean": 0.3341088995719526, "std": 1.1764326310317936, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 2.3749402199904357, "bin_500": 3.9290060851926976}}, "pval": {"value": 0.0397351570615531, "mean": 0.3985277581822796, "std": 0.3016026507368399, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.357118555081159, "bin_500": 0.0541965943180989}}, "signature_idxs": {"edge": [199, 316, 326], "full": [1355, 517, 326, 316, 199]}}, "Rhog gtpase cycle": {"direction": "up", "overlap": {"value": 9, "mean": 9.8373786407767, "std": 4.308521802053122, "bin": {"bin_hit": 2, "bin_50": 0, "bin_100": 1, "bin_250": 5, "bin_500": 10}}, "setsize": {"value": 34, "mean": 35.66504854368932, "std": 2.993429981792782, "bin": {"bin_hit": 71, "bin_50": 71, "bin_100": 71, "bin_250": 71, "bin_500": 71}}, "score": {"value": 2.0530854688550417, "mean": 0.6614029400837433, "std": 0.9950331841901028, "bin": {"bin_hit": 2.5681672438117227, "bin_50": 0.0, "bin_100": 1.476877761413844, "bin_250": 3.093851740545956, "bin_500": 3.251366120218579}}, "pval": {"value": 0.0400642890117994, "mean": 0.4973720188279035, "std": 0.3588671909523165, "bin": {"bin_hit": 0.1908170876358523, "bin_50": 1.0, "bin_100": 0.497470817800254, "bin_250": 0.0285848308842562, "bin_500": 0.0021618403257682}}, "signature_idxs": {"edge": [135, 265, 266, 76, 112, 345, 147, 344, 155], "full": [76, 604, 1942, 155, 2496, 265, 2351, 2999, 1284, 344, 867, 266, 1287, 757, 1622, 2457, 2238, 2054, 703, 354, 135, 1332, 147, 2416, 815, 784, 345, 1338, 112, 1346, 3081, 2120, 962, 1123]}}, "Metabolism of steroids": {"direction": "up", "overlap": {"value": 17, "mean": 11.16019417475728, "std": 4.702670999060317, "bin": {"bin_hit": 3, "bin_50": 1, "bin_100": 4, "bin_250": 12, "bin_500": 18}}, "setsize": {"value": 45, "mean": 45.26699029126213, "std": 5.049423467032678, "bin": {"bin_hit": 103, "bin_50": 103, "bin_100": 103, "bin_250": 103, "bin_500": 103}}, "score": {"value": 2.052202888353792, "mean": 0.7621248609364072, "std": 1.2014135082145578, "bin": {"bin_hit": 2.673482142857143, "bin_50": 2.051674836601307, "bin_100": 4.297872340425532, "bin_250": 5.531727846621464, "bin_500": 4.259660349495447}}, "pval": {"value": 0.0401499489022982, "mean": 0.3994790342082778, "std": 0.3371477938402821, "bin": {"bin_hit": 0.1103983243400622, "bin_50": 0.3926779415133941, "bin_100": 0.0172011735219368, "bin_250": 6.78668198438223e-06, "bin_500": 2.001607730797324e-06}}, "signature_idxs": {"edge": [224, 226, 35, 346, 122, 294, 236, 74, 360, 208, 370, 147, 245, 63, 58, 158, 255], "full": [3164, 360, 966, 224, 1194, 942, 245, 122, 2401, 2842, 1847, 2640, 2607, 58, 581, 255, 226, 1401, 1324, 2746, 2321, 1200, 2825, 3190, 2913, 403, 147, 74, 2693, 294, 2874, 63, 998, 1463, 921, 35, 158, 236, 2208, 550, 346, 1828, 1738, 208, 370]}}, "Iron uptake and transport": {"direction": "up", "overlap": {"value": 5, "mean": 4.089805825242719, "std": 2.0477771422769826, "bin": {"bin_hit": 3, "bin_50": 1, "bin_100": 3, "bin_250": 5, "bin_500": 7}}, "setsize": {"value": 17, "mean": 17.9126213592233, "std": 0.9863810102632052, "bin": {"bin_hit": 38, "bin_50": 38, "bin_100": 38, "bin_250": 38, "bin_500": 38}}, "score": {"value": 2.0487028428817844, "mean": 1.0360420001787272, "std": 1.0014322629164618, "bin": {"bin_hit": 7.688265306122449, "bin_50": 5.692567567567568, "bin_100": 9.079398496240602, "bin_250": 6.208364638116704, "bin_500": 4.464872353057589}}, "pval": {"value": 0.0404911810549768, "mean": 0.323786301352462, "std": 0.2971986354372174, "bin": {"bin_hit": 0.0088495755843915, "bin_50": 0.1675604235637086, "bin_100": 0.005693097574516, "bin_250": 0.0020925837152473, "bin_500": 0.0020949039384023}}, "signature_idxs": {"edge": [69, 230, 71, 138, 17], "full": [3153, 265, 17, 1846, 2639, 1280, 69, 1617, 2864, 466, 2460, 1807, 230, 2112, 138, 1980, 71]}}, "Selective autophagy": {"direction": "up", "overlap": {"value": 13, "mean": 7.315533980582524, "std": 3.350474746292583, "bin": {"bin_hit": 3, "bin_50": 3, "bin_100": 3, "bin_250": 3, "bin_500": 9}}, "setsize": {"value": 32, "mean": 31.50728155339806, "std": 3.101431769008479, "bin": {"bin_hit": 67, "bin_50": 67, "bin_100": 67, "bin_250": 67, "bin_500": 67}}, "score": {"value": 2.0355024655662333, "mean": 0.9304065525388932, "std": 1.074438805028982, "bin": {"bin_hit": 4.1923828125, "bin_50": 10.274796195652174, "bin_100": 4.950986842105263, "bin_250": 1.8990138319672127, "bin_500": 3.0722226155915884}}, "pval": {"value": 0.0418003407174696, "mean": 0.4028226131520862, "std": 0.3502038092942861, "bin": {"bin_hit": 0.039768691440396, "bin_50": 0.0040269256520789, "bin_100": 0.0264876267470493, "bin_250": 0.2210522410556178, "bin_500": 0.0049033414590001}}, "signature_idxs": {"edge": [566, 612, 320, 543, 7, 328, 41, 390, 16, 404, 280, 378, 651], "full": [1101, 1131, 1316, 2735, 651, 390, 1063, 566, 2354, 1399, 7, 543, 2969, 1040, 1624, 2048, 320, 812, 691, 612, 1913, 280, 328, 41, 1052, 2759, 1596, 3098, 378, 404, 16, 1162]}}, "Hdacs deacetylate histones": {"direction": "dw", "overlap": {"value": 7, "mean": 6.614077669902913, "std": 3.12430122265599, "bin": {}}, "setsize": {"value": 13, "mean": 13.390776699029129, "std": 1.938424036750778, "bin": {}}, "score": {"value": -2.0141249689556657, "mean": -0.9216890307937898, "std": 0.846316866971374, "bin": {}}, "pval": {"value": 0.0439964146393658, "mean": 0.3846533048332129, "std": 0.3089780404632911, "bin": {}}, "signature_idxs": {"edge": [2834, 2699, 3118, 3015, 3060, 2478, 2486], "full": [3118, 1940, 1987, 3015, 3060, 1629, 1079, 1369, 2478, 2834, 2699, 2486, 2258]}}, "Apoptosis induced dna fragmentation": {"direction": "dw", "overlap": {"value": 7, "mean": 4.461165048543689, "std": 1.815774087232708, "bin": {}}, "setsize": {"value": 10, "mean": 9.480582524271844, "std": 0.7956871918457745, "bin": {}}, "score": {"value": -2.010164094813019, "mean": -1.2396777487494677, "std": 1.1955398659006715, "bin": {}}, "pval": {"value": 0.0444138241812437, "mean": 0.2413940671270342, "std": 0.28131040332984, "bin": {}}, "signature_idxs": {"edge": [2721, 2742, 2954, 2693, 3117, 3085, 3028], "full": [3117, 2954, 802, 3085, 3028, 2230, 380, 2742, 2721, 2693]}}, "Cdc42 gtpase cycle": {"direction": "up", "overlap": {"value": 14, "mean": 7.257281553398058, "std": 4.162572532194031, "bin": {"bin_hit": 1, "bin_50": 0, "bin_100": 1, "bin_250": 4, "bin_500": 7}}, "setsize": {"value": 35, "mean": 31.66747572815534, "std": 5.251778287537443, "bin": {"bin_hit": 134, "bin_50": 134, "bin_100": 134, "bin_250": 134, "bin_500": 134}}, "score": {"value": 2.0094115303695443, "mean": 0.304554686177821, "std": 0.6843163757439207, "bin": {"bin_hit": 0.6561139691333597, "bin_50": 0.0, "bin_100": 0.7724207425780947, "bin_250": 1.2433048433048433, "bin_500": 1.0790299985507947}}, "pval": {"value": 0.0444935084212969, "mean": 0.6614869417695575, "std": 0.2978793385828449, "bin": {"bin_hit": 0.7834693788743143, "bin_50": 1.0, "bin_100": 0.7282146293156844, "bin_250": 0.4087353821103066, "bin_500": 0.4789376806029824}}, "signature_idxs": {"edge": [703, 604, 757, 135, 265, 137, 669, 433, 784, 538, 500, 147, 84, 344], "full": [1097, 2345, 2531, 1490, 604, 265, 669, 2042, 137, 1284, 344, 1323, 1287, 757, 1622, 1624, 703, 135, 2938, 1043, 147, 2013, 1372, 784, 1338, 433, 925, 500, 1970, 1928, 962, 1123, 84, 538, 825]}}, "Assembly of active lpl and lipc lipase complexes": {"direction": "up", "overlap": {"value": 0, "mean": 0.2733118971061093, "std": 0.4456596279744991, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_hit": 7, "bin_50": 7, "bin_100": 7, "bin_250": 7, "bin_500": 7}}, "score": {"value": 1.994868290213338, "mean": 1.00371785033471, "std": 1.903647207670957, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.046057246785768, "mean": 0.1775133460681621, "std": 0.233581779283167, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [631]}}, "Mitochondrial trna aminoacylation": {"direction": "dw", "overlap": {"value": 10, "mean": 7.165048543689321, "std": 3.6592669629833474, "bin": {}}, "setsize": {"value": 18, "mean": 16.62378640776699, "std": 1.831948729782882, "bin": {}}, "score": {"value": -1.990712720063978, "mean": -0.6180611316575642, "std": 0.7621486806873613, "bin": {}}, "pval": {"value": 0.046512479480169, "mean": 0.5231440727245715, "std": 0.3181724160645508, "bin": {}}, "signature_idxs": {"edge": [2641, 2836, 2246, 2472, 3090, 2243, 2944, 2726, 2650, 2919], "full": [1577, 2641, 1755, 1756, 2726, 2650, 2243, 1415, 1812, 2472, 2246, 1345, 742, 3090, 2919, 2836, 2944, 1877]}}, "Cooperation of pdcl phlp1 and tric cct in g protein beta folding": {"direction": "dw", "overlap": {"value": 9, "mean": 6.334951456310679, "std": 3.1421719264100174, "bin": {}}, "setsize": {"value": 11, "mean": 12.04126213592233, "std": 1.4093124259045722, "bin": {}}, "score": {"value": -1.9859930581443264, "mean": -0.3771213038586288, "std": 0.7983609431504407, "bin": {}}, "pval": {"value": 0.047034094722087, "mean": 0.5715949221250719, "std": 0.3041883117429877, "bin": {}}, "signature_idxs": {"edge": [2968, 2317, 2048, 1993, 2119, 2099, 2098, 2935, 2866], "full": [1993, 1399, 2935, 2866, 2317, 2968, 2098, 2099, 2048, 1459, 2119]}}, "Insertion of tail anchored proteins into the endoplasmic reticulum membrane": {"direction": "up", "overlap": {"value": 5, "mean": 4.016990291262136, "std": 1.9514004604865949, "bin": {"bin_hit": 2, "bin_50": 1, "bin_100": 2, "bin_250": 3, "bin_500": 6}}, "setsize": {"value": 11, "mean": 10.99757281553398, "std": 1.181365809872934, "bin": {"bin_hit": 19, "bin_50": 19, "bin_100": 19, "bin_250": 19, "bin_500": 19}}, "score": {"value": 1.975484926086129, "mean": 1.1239772251284714, "std": 1.0815649178051203, "bin": {"bin_hit": 10.47787610619469, "bin_50": 11.72337962962963, "bin_100": 12.354166666666666, "bin_250": 7.632940573770492, "bin_500": 9.124332810047097}}, "pval": {"value": 0.0482131435775778, "mean": 0.2752182956921286, "std": 0.2865915409883788, "bin": {"bin_hit": 0.0190282844735923, "bin_50": 0.0875404472016038, "bin_100": 0.014058804472369, "bin_250": 0.0102137155300364, "bin_500": 0.0002026911007435}}, "signature_idxs": {"edge": [130, 354, 266, 17, 62], "full": [619, 1747, 438, 17, 62, 266, 130, 3059, 354, 2280, 2256]}}, "Regulation of fzd by ubiquitination": {"direction": "up", "overlap": {"value": 0, "mean": 0.4954954954954955, "std": 0.4999797090274452, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_hit": 9, "bin_50": 9, "bin_100": 9, "bin_250": 9, "bin_500": 9}}, "score": {"value": 1.9723903920122967, "mean": -0.0491391957652045, "std": 1.847152354926592, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.04856505781223, "mean": 0.2655774779651678, "std": 0.2905707428993939, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [622]}}, "Metabolism of water soluble vitamins and cofactors": {"direction": "dw", "overlap": {"value": 6, "mean": 8.531553398058252, "std": 3.474103155144582, "bin": {}}, "setsize": {"value": 35, "mean": 36.74271844660194, "std": 4.348509440902812, "bin": {}}, "score": {"value": -1.969870379730733, "mean": -1.2385108719406173, "std": 1.672558535712947, "bin": {}}, "pval": {"value": 0.0488532279223501, "mean": 0.2845253733939605, "std": 0.3228771741911537, "bin": {}}, "signature_idxs": {"edge": [3136, 3178, 3181, 3188, 3190, 3164], "full": [3164, 2497, 352, 1787, 3178, 1031, 863, 3181, 2792, 2500, 1357, 888, 1170, 2999, 654, 33, 1401, 2720, 145, 1292, 3190, 2420, 3136, 762, 1217, 3188, 679, 47, 405, 1388, 2389, 484, 706, 2601, 2493]}}, "Metabolism of nucleotides": {"direction": "dw", "overlap": {"value": 20, "mean": 13.689320388349516, "std": 8.929637710188212, "bin": {}}, "setsize": {"value": 42, "mean": 45.83252427184466, "std": 3.5415166567437466, "bin": {}}, "score": {"value": -1.968220185328423, "mean": -1.1184294987896846, "std": 1.2782778290942398, "bin": {}}, "pval": {"value": 0.0490427087206239, "mean": 0.354071171489312, "std": 0.3409376828853995, "bin": {}}, "signature_idxs": {"edge": [2539, 2672, 2542, 2813, 3086, 2822, 2575, 2841, 2982, 2453, 3130, 3132, 2738, 3016, 2767, 2502, 3189, 2929, 2403, 2536], "full": [1237, 446, 751, 2672, 2575, 2929, 2982, 2536, 2841, 3016, 3130, 969, 2453, 2539, 3086, 2403, 2813, 2502, 1104, 2738, 2045, 2095, 866, 2542, 2767, 3189, 808, 1037, 2822, 700, 702, 2010, 2052, 2198, 251, 3132, 2171, 97, 1527, 1485, 2342, 709]}}, "Signaling by tgfb family members": {"direction": "dw", "overlap": {"value": 8, "mean": 7.560679611650485, "std": 4.005300798889431, "bin": {}}, "setsize": {"value": 19, "mean": 20.890776699029125, "std": 3.1415184595494696, "bin": {}}, "score": {"value": -1.9658644432076429, "mean": -0.544474279600977, "std": 0.9821118286747472, "bin": {}}, "pval": {"value": 0.0493142713142311, "mean": 0.4993154578105486, "std": 0.3262156715097325, "bin": {}}, "signature_idxs": {"edge": [3140, 2904, 2892, 2668, 2708, 3096, 2762, 3032], "full": [2261, 2040, 1500, 2892, 1136, 3032, 3096, 3140, 481, 1079, 1630, 2281, 1967, 2762, 1831, 2708, 647, 2668, 2904]}}, "Ncam signaling for neurite out growth": {"direction": "dw", "overlap": {"value": 2, "mean": 2.783980582524272, "std": 1.7748063423993672, "bin": {}}, "setsize": {"value": 6, "mean": 6.131067961165049, "std": 1.1114172816822927, "bin": {}}, "score": {"value": -1.9653344262362509, "mean": 0.0445974593882081, "std": 0.8210358492109823, "bin": {}}, "pval": {"value": 0.0493755435697913, "mean": 0.5793679502045885, "std": 0.2965960714016829, "bin": {}}, "signature_idxs": {"edge": [3157, 2892], "full": [3157, 2892, 1136, 1142, 1327, 1041]}}, "Synthesis of pips at the er membrane": {"direction": "up", "overlap": {"value": 0, "mean": 0.9635922330097088, "std": 0.8396339405445871, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 2.4927184466019416, "std": 0.8518656785667076, "bin": {"bin_hit": 5, "bin_50": 5, "bin_100": 5, "bin_250": 5, "bin_500": 5}}, "score": {"value": 1.9620080912670483, "mean": 0.1586958641203857, "std": 1.0703766948116784, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.04976154224016, "mean": 0.549865457296423, "std": 0.3329220100508978, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [645]}}, "Crmps in sema3a signaling": {"direction": "dw", "overlap": {"value": 3, "mean": 2.4563106796116503, "std": 1.4814496903477947, "bin": {}}, "setsize": {"value": 5, "mean": 4.932038834951456, "std": 1.3883155675121923, "bin": {}}, "score": {"value": -1.9616570134585691, "mean": -0.4888651658337851, "std": 0.9727295713044456, "bin": {}}, "pval": {"value": 0.049802429685487, "mean": 0.4478418486297705, "std": 0.2980485789177581, "bin": {}}, "signature_idxs": {"edge": [3077, 2760, 3115], "full": [1236, 1717, 3077, 3115, 2760]}}, "Sumoylation of transcription cofactors": {"direction": "dw", "overlap": {"value": 7, "mean": 5.114077669902913, "std": 2.6756898890411236, "bin": {}}, "setsize": {"value": 11, "mean": 11.735436893203884, "std": 2.747533148363699, "bin": {}}, "score": {"value": -1.961619097029752, "mean": -0.8398302807631189, "std": 0.840353098064034, "bin": {}}, "pval": {"value": 0.0498068472176846, "mean": 0.4162141800138964, "std": 0.300914418096352, "bin": {}}, "signature_idxs": {"edge": [2400, 3046, 2716, 2366, 2778, 2779, 3098], "full": [2400, 2716, 1912, 2200, 2366, 3046, 2778, 1823, 2779, 3098, 1436]}}}}