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"signature_idxs": {"edge": [2805, 2803, 2544, 2441, 3088, 2422, 2955, 2552, 2828, 3097, 2835, 2432, 2611, 2743, 2326, 3120, 2470, 2478, 2733, 2999, 2856, 2633, 2385, 2476, 2945, 3145, 2358, 2530, 2752, 3156, 2886, 2669, 3047, 3053, 3051, 2407, 2773, 2408, 2641, 2646, 2932, 2401, 3057, 2572, 2946, 3073], "full": [2422, 1956, 2358, 2641, 2773, 1963, 2646, 1390, 2544, 2733, 2828, 1302, 2955, 847, 1676, 2401, 2470, 1574, 1209, 2856, 2752, 2432, 2279, 2999, 2326, 2476, 2552, 1921, 2803, 3145, 2886, 756, 1924, 3097, 730, 2407, 2478, 1736, 3120, 2805, 2129, 2835, 2408, 3047, 2441, 2206, 1225, 1368, 2030, 3156, 2251, 2633, 1700, 3051, 3057, 2945, 2297, 2385, 2215, 738, 2946, 2572, 499, 3073, 2530, 3088, 3053, 2044, 2743, 2190, 2669, 2932, 1903, 2611, 1760]}}, "Transport of mature transcript to cytoplasm": {"direction": "dw", "overlap": {"value": 37, "mean": 22.179611650485437, "std": 9.223322687761865, "bin": {}}, "setsize": {"value": 62, "mean": 63.12378640776699, "std": 3.3978458671491603, 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{"value": 58, "mean": 59.20145631067961, "std": 1.9447958476066176, "bin": {}}, "score": {"value": -3.7458502464713854, "mean": -0.8147971705983226, "std": 0.8179645885680109, "bin": {}}, "pval": {"value": 0.0001797838202957, "mean": 0.5007159783220774, "std": 0.3476916341303011, "bin": {}}, "signature_idxs": {"edge": [3066, 3076, 2441, 2549, 2552, 3093, 2432, 2470, 2852, 2999, 3129, 2633, 3131, 2476, 2945, 3145, 3147, 2882, 2612, 2530, 3156, 2504, 3168, 3053, 2774, 2641, 2932, 2401, 2685, 2572, 3073], "full": [2612, 1956, 2641, 1160, 3066, 2852, 3093, 1768, 2774, 1348, 2315, 3076, 960, 1302, 2504, 997, 453, 1965, 3129, 1536, 1537, 2401, 2470, 2549, 3168, 1576, 2432, 2279, 2882, 2999, 1630, 2476, 2552, 3147, 3145, 2685, 479, 1924, 1051, 3131, 2441, 2206, 1225, 2030, 3156, 2251, 2633, 1700, 2945, 2572, 140, 499, 3073, 2530, 3053, 259, 1025, 2932]}}, "Sumoylation of dna replication proteins": {"direction": "dw", "overlap": {"value": 24, "mean": 11.87864077669903, "std": 6.042714468888302, "bin": {}}, "setsize": {"value": 35, "mean": 34.529126213592235, "std": 2.1056157491572995, "bin": {}}, "score": {"value": -3.561960620250037, "mean": -0.4394927336061675, "std": 0.8592766121011057, "bin": {}}, "pval": {"value": 0.0003680956062628, "mean": 0.6339198960271976, "std": 0.3172919285231038, "bin": {}}, "signature_idxs": {"edge": [2544, 2441, 3088, 2422, 2552, 2828, 2432, 2470, 2733, 2999, 2633, 2476, 3073, 3145, 2530, 2752, 3156, 2886, 3053, 2641, 2932, 2401, 2572, 2945], "full": [2422, 1956, 2641, 2544, 2733, 2828, 1302, 2401, 2470, 2752, 2432, 2279, 2999, 2476, 2552, 3145, 2886, 1924, 2441, 2206, 1225, 2030, 3156, 2251, 2633, 1700, 2945, 2297, 2572, 499, 3073, 2530, 3088, 3053, 2932]}}, "Cytoprotection by hmox1": {"direction": "up", "overlap": {"value": 9, "mean": 15.264563106796116, "std": 6.884300879212943, "bin": {"bin_hit": 1, "bin_50": 5, "bin_100": 7, "bin_250": 10, "bin_500": 14}}, "setsize": {"value": 63, "mean": 64.83495145631068, "std": 3.5957015529431366, "bin": {"bin_hit": 110, "bin_50": 110, "bin_100": 110, "bin_250": 110, "bin_500": 110}}, "score": {"value": 3.54060626279857, "mean": 0.939000341067099, "std": 1.0482386655891682, "bin": {"bin_hit": 13.209698558322412, "bin_50": 10.867965367965368, "bin_100": 7.464525765496639, "bin_250": 4.137815126050421, "bin_500": 2.8994565217391304}}, "pval": {"value": 0.0003992088418456, "mean": 0.4699320360831873, "std": 0.3835416044430508, "bin": {"bin_hit": 0.0831462143307864, "bin_50": 0.0001743266773579, "bin_100": 8.667021087694233e-05, "bin_250": 0.0003359769202791, "bin_500": 0.0008813713911364}}, "signature_idxs": {"edge": [6, 7, 8, 105, 20, 119, 55, 30, 95], "full": [525, 2356, 1907, 1762, 2050, 1993, 417, 1766, 913, 2360, 959, 7, 1350, 2115, 253, 1034, 1916, 1165, 95, 1166, 2467, 119, 2162, 2468, 2400, 55, 20, 105, 6, 1259, 2996, 1040, 1628, 2998, 1261, 1446, 8, 352, 924, 3068, 30, 478, 1631, 2434, 2802, 1266, 1500, 729, 1545, 1639, 1584, 1048, 167, 929, 1739, 1886, 520, 2215, 795, 2143, 2575, 1523, 1295]}}, "Transport of small molecules": {"direction": "up", "overlap": {"value": 29, "mean": 41.730582524271846, "std": 14.87709311863932, "bin": {"bin_hit": 1, "bin_50": 8, "bin_100": 14, "bin_250": 23, "bin_500": 36}}, "setsize": {"value": 147, "mean": 151.96601941747574, "std": 12.598305121005488, "bin": {"bin_hit": 377, "bin_50": 377, "bin_100": 377, "bin_250": 377, "bin_500": 377}}, "score": {"value": 3.536542107286813, "mean": 1.4265613612661356, "std": 1.746958952072276, "bin": {"bin_hit": 3.7279635258358654, "bin_50": 5.170467314429242, "bin_100": 4.46969696969697, "bin_250": 2.770395480225989, "bin_500": 2.1430398025457853}}, "pval": {"value": 0.0004054018701937, "mean": 0.380396759556163, "std": 0.4128488770716938, "bin": {"bin_hit": 0.2603033509768693, "bin_50": 0.0003870332317472, "bin_100": 1.3546346694347647e-05, "bin_250": 4.539969818620608e-05, "bin_500": 8.189843177861568e-05}}, "signature_idxs": {"edge": [6, 7, 8, 265, 262, 18, 153, 20, 152, 280, 147, 26, 30, 297, 38, 167, 55, 187, 78, 82, 208, 88, 94, 95, 102, 105, 119, 259, 260], "full": [525, 2356, 1907, 2050, 1993, 208, 417, 673, 3084, 913, 187, 2729, 2059, 262, 627, 749, 2991, 2644, 1161, 2000, 1486, 147, 2061, 1769, 7, 676, 2695, 527, 751, 2829, 1821, 1916, 2647, 1089, 95, 3009, 2649, 576, 26, 2467, 119, 2162, 2468, 577, 2400, 55, 20, 105, 752, 6, 2508, 3012, 1259, 2426, 324, 1207, 1000, 2996, 1039, 1208, 3113, 2959, 1726, 2998, 38, 1261, 1446, 8, 352, 1869, 291, 1731, 82, 2369, 1211, 3068, 2982, 2624, 30, 478, 2554, 1131, 1631, 2434, 2802, 2370, 1266, 2514, 3026, 1686, 1635, 729, 855, 2861, 1545, 265, 1692, 2656, 1584, 167, 929, 1504, 1835, 460, 1740, 1643, 88, 974, 1105, 613, 2599, 280, 638, 824, 18, 587, 1648, 793, 1846, 1373, 795, 2143, 1414, 831, 664, 1894, 619, 297, 94, 2768, 1852, 78, 483, 2873, 1290, 152, 259, 1195, 1710, 1558, 1523, 1295, 744, 260, 153, 1905, 102]}}, "Hcmv early events": {"direction": "dw", "overlap": {"value": 31, "mean": 12.46359223300971, "std": 5.833959396627051, "bin": {}}, "setsize": {"value": 47, "mean": 44.35436893203884, "std": 3.0514448813454176, "bin": {}}, "score": {"value": -3.5000710127727044, "mean": -0.2344123619104917, "std": 0.7325989596008913, "bin": {}}, "pval": {"value": 0.0004651342302368, "mean": 0.6821756516237598, "std": 0.2957065288821427, "bin": {}}, "signature_idxs": {"edge": [2803, 2441, 2552, 2333, 2432, 2313, 2487, 2329, 2470, 2999, 2633, 2476, 2945, 3145, 2530, 3156, 2498, 2669, 3053, 2911, 2408, 2641, 2513, 2414, 2932, 3181, 2401, 2570, 2572, 3073, 2279], "full": [1956, 1530, 2498, 2641, 2313, 1441, 1302, 2401, 2470, 2432, 2279, 2999, 2476, 2552, 2803, 2513, 2329, 3145, 1214, 1924, 730, 969, 3181, 2333, 1319, 2408, 2911, 2441, 2206, 1225, 2030, 3156, 2251, 2633, 1700, 2945, 2570, 2572, 499, 2414, 2487, 3073, 2530, 3053, 2669, 2932, 839]}}, "Sumoylation of chromatin organization proteins": {"direction": "dw", "overlap": {"value": 23, "mean": 11.148058252427184, "std": 6.207568283684575, "bin": {}}, "setsize": {"value": 34, "mean": 34.599514563106794, "std": 2.8747815041129403, "bin": {}}, "score": {"value": -3.490963660650209, "mean": -0.387582479755537, "std": 0.8509909414976633, "bin": {}}, "pval": {"value": 0.0004812817099839, "mean": 0.6402143361070456, "std": 0.3129766703279643, "bin": {}}, "signature_idxs": {"edge": [2803, 2441, 2552, 2835, 2432, 3120, 2470, 2999, 2856, 2633, 2476, 3073, 3145, 2530, 3156, 3053, 3051, 2408, 2641, 2932, 2401, 2572, 2945], "full": [1956, 2641, 1302, 2401, 2470, 2856, 2432, 2279, 2999, 2476, 2552, 2803, 3145, 1924, 3120, 2835, 2408, 2441, 2206, 1225, 2030, 3156, 2251, 2633, 1700, 3051, 2945, 738, 2572, 499, 3073, 2530, 3053, 2932]}}, "Glycolysis": {"direction": "dw", "overlap": {"value": 27, "mean": 15.689320388349516, "std": 6.7838029919266996, "bin": {}}, "setsize": {"value": 47, "mean": 48.25, "std": 1.7689679400191327, "bin": {}}, "score": {"value": -3.4348806272288983, "mean": -0.5958328957109971, "std": 0.6637854035560473, "bin": {}}, "pval": {"value": 0.0005928149036658, "mean": 0.5882658415056724, "std": 0.3203296862218684, "bin": {}}, "signature_idxs": {"edge": [3076, 2441, 2552, 3093, 2432, 2470, 2852, 2999, 3129, 2633, 2476, 2945, 3145, 3147, 2882, 2612, 2530, 3156, 2504, 3053, 2774, 2641, 2932, 2401, 2685, 2572, 3073], "full": [2612, 1956, 2641, 2852, 3093, 1768, 2774, 1348, 2315, 3076, 1302, 2504, 453, 1965, 3129, 1536, 1537, 2401, 2470, 1576, 2432, 2279, 2882, 2999, 2476, 2552, 3147, 3145, 2685, 1924, 1051, 2441, 2206, 1225, 2030, 3156, 2251, 2633, 1700, 2945, 2572, 140, 499, 3073, 2530, 3053, 2932]}}, "Transport of the slbp dependant mature mrna": {"direction": "dw", "overlap": {"value": 20, "mean": 10.322815533980584, "std": 5.796731907776354, "bin": {}}, "setsize": {"value": 30, "mean": 30.57281553398058, "std": 1.4217583926734303, "bin": {}}, "score": {"value": -3.431143235765781, "mean": -0.2113838159701244, "std": 0.8670118169659932, "bin": {}}, "pval": {"value": 0.0006010431477876, "mean": 0.6750134343387901, "std": 0.3193959539823727, "bin": {}}, "signature_idxs": {"edge": [2441, 2552, 2436, 2432, 2482, 2988, 2470, 2999, 2633, 2476, 3073, 3145, 2530, 3156, 3053, 2641, 2932, 2401, 2572, 2945], "full": [1956, 2641, 1302, 2401, 2470, 2432, 2279, 2999, 2476, 2552, 3145, 2436, 1924, 2441, 2206, 2482, 1225, 2030, 3156, 2251, 2633, 1700, 2945, 2572, 499, 3073, 2530, 3053, 2988, 2932]}}, "Processing of capped intron containing pre mrna": {"direction": "dw", "overlap": {"value": 72, "mean": 61.44660194174757, "std": 22.544983363510543, "bin": {}}, "setsize": {"value": 181, "mean": 182.83009708737865, "std": 8.980305689776722, "bin": {}}, "score": {"value": -3.42420683796536, "mean": -0.6525536485470969, "std": 1.3401481761909957, "bin": {}}, "pval": {"value": 0.0006165967145583, "mean": 0.5600064525169441, "std": 0.3579178268520561, "bin": {}}, "signature_idxs": {"edge": [3075, 2713, 2841, 2441, 2845, 2955, 2552, 2953, 2837, 2952, 2604, 2709, 2694, 3095, 2429, 2423, 2436, 2432, 2832, 2482, 3109, 3110, 2595, 3114, 2988, 2470, 2464, 2999, 2732, 2633, 2471, 2476, 2477, 2896, 2890, 2522, 3142, 2902, 3145, 2891, 3073, 2889, 2530, 2888, 2877, 2373, 3156, 2520, 2371, 3069, 2788, 2409, 3036, 2502, 2638, 3053, 2497, 2643, 2420, 2641, 2646, 2909, 2932, 2394, 2395, 3046, 2401, 2572, 2810, 2945, 2799, 2941], "full": [2638, 1529, 1956, 3075, 2877, 1764, 1957, 1814, 773, 2694, 2464, 842, 2055, 1248, 2952, 2423, 1625, 2497, 957, 1996, 2641, 2953, 289, 2394, 2395, 573, 2643, 2646, 1442, 2002, 1488, 2062, 2502, 2732, 1255, 1302, 919, 3095, 778, 2955, 2832, 717, 1674, 2799, 1535, 2006, 1308, 1867, 1775, 556, 678, 2401, 2470, 1725, 2471, 2011, 2429, 2432, 2279, 2168, 2073, 679, 1540, 304, 2999, 2476, 3069, 1354, 2552, 1921, 353, 1683, 1265, 1633, 3114, 2909, 2477, 149, 3145, 1358, 2371, 1873, 2199, 2941, 398, 1215, 1832, 2888, 2436, 2889, 1924, 1925, 2373, 1691, 2890, 2891, 2709, 2595, 1047, 1927, 2332, 2172, 3036, 2837, 2713, 2409, 3046, 1454, 2020, 1362, 1408, 2520, 2334, 1547, 342, 2441, 1220, 2522, 189, 562, 3142, 2206, 2788, 2896, 2482, 1411, 1182, 2810, 1981, 218, 1225, 1137, 331, 2030, 3156, 2841, 2251, 1184, 2633, 1798, 2211, 1550, 1700, 1844, 3109, 2945, 2604, 2346, 3110, 1941, 2572, 499, 1416, 2100, 3073, 2530, 2101, 2845, 1417, 1233, 1748, 1375, 1604, 3053, 2042, 2352, 2988, 135, 1756, 2932, 1075, 2902, 2420, 1809, 2110, 954, 1712, 2268, 2156, 2269, 871]}}, "Mitotic g1 phase and g1 s transition": {"direction": "up", "overlap": {"value": 35, "mean": 22.104368932038835, "std": 11.678595487596883, "bin": {"bin_hit": 0, "bin_50": 4, "bin_100": 7, "bin_250": 15, "bin_500": 23}}, "setsize": {"value": 78, "mean": 76.02184466019418, "std": 5.354610434747646, "bin": {"bin_hit": 143, "bin_50": 143, "bin_100": 143, "bin_250": 143, "bin_500": 143}}, "score": {"value": 3.4174446605514808, "mean": 0.5927262006732629, "std": 1.3736272695770486, "bin": {"bin_hit": 0.0, "bin_50": 6.4, "bin_100": 5.634615384615385, "bin_250": 4.938975321888412, "bin_500": 3.8733649789029534}}, "pval": {"value": 0.000632119436065, "mean": 0.5705780900762646, "std": 0.3846948779804449, "bin": {"bin_hit": 1.0, "bin_50": 0.0048202695093692, "bin_100": 0.0004401013842026, "bin_250": 1.928300828344853e-06, "bin_500": 3.7690068338178674e-07}}, "signature_idxs": {"edge": [632, 8, 795, 14, 800, 20, 397, 525, 529, 777, 277, 30, 293, 422, 697, 417, 301, 55, 588, 729, 72, 209, 221, 216, 215, 95, 598, 352, 478, 719, 225, 105, 718, 236, 119], "full": [525, 2356, 1907, 2050, 1993, 417, 906, 301, 913, 14, 1203, 277, 236, 777, 2733, 215, 2828, 209, 1163, 1916, 95, 422, 781, 2467, 119, 2162, 2468, 1676, 2400, 55, 20, 105, 1536, 1537, 718, 529, 719, 1627, 1038, 397, 2996, 1209, 2998, 1261, 598, 1311, 1446, 8, 1494, 352, 3068, 30, 478, 1631, 2434, 2802, 1872, 1266, 1634, 729, 225, 1545, 1639, 632, 3120, 1584, 293, 929, 216, 795, 2143, 697, 221, 588, 800, 1523, 1295, 72]}}, "Transport of mature mrnas derived from intronless transcripts": {"direction": "dw", "overlap": {"value": 22, "mean": 12.485436893203884, "std": 6.764935404179153, "bin": {}}, "setsize": {"value": 35, "mean": 36.21116504854369, "std": 1.6521746780936135, "bin": {}}, "score": {"value": -3.402839299483729, "mean": -0.3550698997053867, "std": 0.8812161356906153, "bin": {}}, "pval": {"value": 0.000666894928297, "mean": 0.6571229286016341, "std": 0.3228743985516816, "bin": {}}, "signature_idxs": {"edge": [2441, 2552, 2436, 2432, 2482, 2988, 2470, 2999, 2633, 2476, 2522, 3073, 3145, 2530, 2889, 3156, 3053, 2641, 2932, 2401, 2572, 2945], "full": [1956, 2641, 1302, 2401, 2470, 2432, 2279, 2999, 2476, 2552, 3145, 2436, 2889, 1924, 2441, 2522, 2206, 2482, 1225, 2030, 3156, 2251, 2633, 1700, 1844, 2945, 2572, 499, 3073, 2530, 3053, 2352, 2988, 1756, 2932]}}, "Epigenetic regulation of gene expression": {"direction": "dw", "overlap": {"value": 27, "mean": 19.41747572815534, "std": 7.137381793821183, "bin": {}}, "setsize": {"value": 44, "mean": 42.99514563106796, "std": 4.250639669526318, "bin": {}}, "score": {"value": -3.355698186617498, "mean": -1.2342556202270925, "std": 1.1738716287747466, "bin": {}}, "pval": {"value": 0.0007916491163464, "mean": 0.3568884878092889, "std": 0.3574577146020241, "bin": {}}, "signature_idxs": {"edge": [3067, 2803, 2718, 2427, 2581, 2741, 2585, 2586, 2875, 2589, 3120, 3016, 3149, 3160, 2498, 2499, 2911, 3051, 2407, 2408, 3046, 2906, 2566, 3180, 2450, 2452, 2459], "full": [2581, 1954, 2585, 3180, 3149, 2586, 2498, 957, 1484, 2499, 2906, 3067, 2589, 360, 717, 1772, 847, 2427, 679, 2803, 1685, 968, 2407, 3120, 633, 2408, 3046, 2911, 2718, 2566, 3051, 2741, 2215, 2450, 2452, 3016, 1377, 1517, 2263, 2265, 770, 3160, 2459, 2875]}}, "Rrna modification in the nucleus and cytosol": {"direction": "dw", "overlap": {"value": 26, "mean": 28.45631067961165, "std": 9.286985045927665, "bin": {}}, "setsize": {"value": 53, "mean": 54.34466019417476, "std": 2.651734298048095, "bin": {}}, "score": {"value": -3.2885716462906323, "mean": -1.5049432386646604, "std": 1.3675746480917093, "bin": {}}, "pval": {"value": 0.0010069715133955, "mean": 0.3185351385207093, "std": 0.3550565174366032, "bin": {}}, "signature_idxs": {"edge": [2804, 3082, 2710, 2964, 2848, 2607, 2611, 2493, 2745, 3125, 2631, 2386, 3007, 2746, 2661, 3161, 2920, 2916, 2418, 2652, 3061, 2398, 2819, 2446, 2807, 3069], "full": [2746, 1559, 3007, 2052, 1994, 2160, 1718, 1626, 2398, 2652, 850, 3069, 601, 1632, 726, 1732, 2804, 2710, 1930, 1404, 2173, 2807, 403, 2631, 2661, 2916, 1934, 2446, 2140, 1703, 2607, 2260, 1801, 1553, 2386, 3125, 2920, 2418, 2964, 2848, 3082, 1555, 2493, 2266, 706, 1196, 2819, 3161, 2745, 2611, 1079, 3061, 1200]}}, "Interactions of rev with host cellular proteins": {"direction": "dw", "overlap": {"value": 20, "mean": 11.58495145631068, "std": 6.180148829983814, "bin": {}}, "setsize": {"value": 34, "mean": 33.50728155339806, "std": 1.1564279570110754, "bin": {}}, "score": {"value": -3.264101732191343, "mean": -0.3478389893094789, "std": 0.7452203314494521, "bin": {}}, "pval": {"value": 0.0010981172828139, "mean": 0.6970029102376685, "std": 0.2988264925058257, "bin": {}}, "signature_idxs": {"edge": [2441, 2836, 2552, 2432, 2970, 2470, 2999, 2633, 2476, 3073, 3145, 2530, 2752, 3156, 3053, 2641, 2932, 2401, 2572, 2945], "full": [1624, 1956, 2641, 1963, 1302, 2970, 2401, 2470, 1309, 2752, 2432, 2279, 2999, 2476, 2552, 784, 3145, 1924, 2836, 2441, 2206, 1225, 2030, 3156, 2251, 2633, 1700, 2945, 2572, 499, 3073, 2530, 3053, 2932]}}, "Sumoylation of rna binding proteins": {"direction": "dw", "overlap": {"value": 20, "mean": 11.080097087378642, "std": 5.683897540659047, "bin": {}}, "setsize": {"value": 32, "mean": 31.83252427184466, "std": 2.2627439388728945, "bin": {}}, "score": {"value": -3.2486791926835425, "mean": -0.1919874870556263, "std": 0.9298229348189392, "bin": {}}, "pval": {"value": 0.0011594215668881, "mean": 0.649712190416739, "std": 0.3254358140988572, "bin": {}}, "signature_idxs": {"edge": [2441, 2552, 2835, 2432, 2611, 2470, 2999, 2633, 2476, 3073, 3145, 2530, 3156, 3053, 2641, 2646, 2932, 2401, 2572, 2945], "full": [1956, 2641, 2646, 1302, 2401, 2470, 2432, 2279, 2999, 2476, 2552, 1921, 3145, 1924, 2835, 2441, 2206, 1225, 2030, 3156, 2251, 2633, 1700, 2945, 738, 2572, 499, 3073, 2530, 3053, 2932, 2611]}}, "Nuclear import of rev protein": {"direction": "dw", "overlap": {"value": 19, "mean": 10.604368932038836, "std": 5.891105714846815, "bin": {}}, "setsize": {"value": 31, "mean": 30.50728155339806, "std": 1.1564279570110754, "bin": {}}, "score": {"value": -3.231740066025889, "mean": -0.2662730785997009, "std": 0.8169660660518107, "bin": {}}, "pval": {"value": 0.0012303892353402, "mean": 0.6871544752103023, "std": 0.308961068837417, "bin": {}}, "signature_idxs": {"edge": [2441, 2836, 2552, 2432, 2970, 2470, 2999, 2633, 2476, 2945, 3145, 2530, 3156, 3053, 2641, 2932, 2401, 2572, 3073], "full": [1956, 2641, 1963, 1302, 2970, 2401, 2470, 2432, 2279, 2999, 2476, 2552, 784, 3145, 1924, 2836, 2441, 2206, 1225, 2030, 3156, 2251, 2633, 1700, 2945, 2572, 499, 3073, 2530, 3053, 2932]}}, "Transcriptional regulation by small rnas": {"direction": "dw", "overlap": {"value": 23, "mean": 11.655339805825244, "std": 6.260730255420205, "bin": {}}, "setsize": {"value": 39, "mean": 37.407766990291265, "std": 1.997264601261948, "bin": {}}, "score": {"value": -3.134856272980941, "mean": -0.3972224310921288, "std": 0.7366690231446658, "bin": {}}, "pval": {"value": 0.0017193832944886, "mean": 0.6649673755290503, "std": 0.2975390166504904, "bin": {}}, "signature_idxs": {"edge": [3067, 3075, 2803, 2441, 2552, 2432, 2832, 2470, 2999, 2633, 2476, 3073, 3145, 2530, 3156, 3053, 2909, 2641, 2932, 2401, 2572, 2945, 2799], "full": [416, 1956, 3075, 2641, 1302, 3067, 2832, 717, 2799, 1308, 2401, 2470, 2432, 2279, 679, 2999, 2476, 2552, 2909, 2803, 784, 3145, 1685, 1924, 2441, 2206, 1225, 2030, 3156, 2251, 2633, 1700, 2945, 2572, 499, 3073, 2530, 3053, 2932]}}, "Dna replication pre initiation": {"direction": "up", "overlap": {"value": 31, "mean": 16.987864077669904, "std": 9.845276246498855, "bin": {"bin_hit": 0, "bin_50": 3, "bin_100": 6, "bin_250": 12, "bin_500": 19}}, "setsize": {"value": 66, "mean": 61.73300970873787, "std": 3.587542857888571, "bin": {"bin_hit": 92, "bin_50": 92, "bin_100": 92, "bin_250": 92, "bin_500": 92}}, "score": {"value": 3.120597131593491, "mean": 0.4288945668380205, "std": 1.230696609236802, "bin": {"bin_hit": 0.0, "bin_50": 7.370297997068882, "bin_100": 7.592517694641051, "bin_250": 6.272033898305085, "bin_500": 5.241416862497851}}, "pval": {"value": 0.0018048476478513, "mean": 0.5957541730468855, "std": 0.3684137615844171, "bin": {"bin_hit": 1.0, "bin_50": 0.0097083087369112, "bin_100": 0.0002475664110718, "bin_250": 2.1262294697935726e-06, "bin_500": 6.93058719663452e-08}}, "signature_idxs": {"edge": [632, 8, 795, 510, 800, 20, 397, 525, 777, 30, 293, 167, 422, 417, 697, 301, 55, 588, 729, 72, 221, 216, 712, 95, 598, 352, 478, 719, 225, 105, 119], "full": [525, 2356, 1907, 2050, 1993, 417, 906, 712, 301, 913, 777, 1163, 3067, 1916, 95, 422, 781, 2467, 119, 2162, 2468, 1676, 2400, 55, 20, 105, 719, 1627, 1038, 397, 2996, 2998, 1261, 598, 1311, 1446, 8, 1494, 352, 510, 3068, 30, 478, 1631, 2434, 2802, 2803, 1685, 729, 225, 1545, 632, 293, 2836, 167, 929, 216, 795, 2143, 697, 221, 588, 800, 1523, 1295, 72]}}, "Activation of the pre replicative complex": {"direction": "up", "overlap": {"value": 15, "mean": 5.689320388349515, "std": 4.264391114445643, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 1, "bin_250": 4, "bin_500": 8}}, "setsize": {"value": 23, "mean": 20.37864077669903, "std": 3.0060343997875663, "bin": {"bin_hit": 33, "bin_50": 33, "bin_100": 33, "bin_250": 33, "bin_500": 33}}, "score": {"value": 3.096700502335024, "mean": 0.257943935461773, "std": 0.8125565328981424, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 3.2429123711340204, "bin_250": 5.607122668174109, "bin_500": 6.3306339468302655}}, "pval": {"value": 0.0019568747385489, "mean": 0.622644435072912, "std": 0.3151513491599574, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 0.2732850813359189, "bin_250": 0.0080316637526189, "bin_500": 0.0001419239292943}}, "signature_idxs": {"edge": [598, 719, 225, 632, 588, 72, 422, 800, 697, 301, 397, 221, 777, 216, 293], "full": [906, 301, 777, 1163, 422, 781, 1676, 719, 1627, 1038, 397, 598, 1311, 1494, 225, 632, 293, 216, 697, 221, 588, 800, 72]}}, "Hemostasis": {"direction": "dw", "overlap": {"value": 38, "mean": 23.70873786407767, "std": 9.138769507748338, "bin": {}}, "setsize": {"value": 120, "mean": 121.62864077669904, "std": 12.539276356734876, "bin": {}}, "score": {"value": -3.081561000353319, "mean": -0.1302504040085788, "std": 0.8159691531438237, "bin": {}}, "pval": {"value": 0.0020591827990363, "mean": 0.6859796633498921, "std": 0.3286641842384732, "bin": {}}, "signature_idxs": {"edge": [2545, 2546, 2850, 2700, 2824, 3093, 2829, 2972, 3104, 2706, 2707, 2739, 3120, 2736, 2731, 3122, 2730, 2856, 2995, 2626, 3012, 2884, 3027, 2876, 3033, 3051, 2773, 2904, 2644, 2514, 3043, 2508, 3181, 2647, 3192, 2576, 2690, 2673], "full": [2049, 2876, 2904, 1247, 288, 1960, 2673, 275, 2730, 2824, 1252, 3093, 2313, 2773, 3122, 2644, 1720, 1441, 2114, 1864, 67, 1086, 2731, 2061, 3033, 676, 1820, 1303, 2829, 242, 1821, 2063, 2995, 779, 1771, 2647, 998, 2545, 3043, 422, 2546, 2234, 1168, 2972, 1536, 1537, 2508, 3012, 1572, 1392, 1000, 2736, 1393, 9, 2856, 2700, 1729, 2431, 962, 1730, 82, 2369, 2884, 1356, 440, 3104, 1499, 2514, 2329, 2015, 2626, 1685, 1687, 1734, 1099, 2739, 1831, 426, 535, 2706, 1360, 2707, 1402, 3181, 3120, 3027, 2333, 1975, 1051, 2376, 441, 635, 203, 233, 976, 2183, 133, 1648, 3051, 1278, 1141, 1229, 2215, 2690, 2414, 3192, 2487, 1746, 1600, 1851, 2576, 546, 1654, 284, 321, 1948, 1757, 2112, 504, 2850]}}, "Export of viral ribonucleoproteins from nucleus": {"direction": "dw", "overlap": {"value": 17, "mean": 9.808252427184469, "std": 5.676953053805842, "bin": {}}, "setsize": {"value": 29, "mean": 28.50728155339806, "std": 1.1564279570110754, "bin": {}}, "score": {"value": -3.056215833921446, "mean": -0.1738412669472448, "std": 0.8082327013713511, "bin": {}}, "pval": {"value": 0.0022414983905285, "mean": 0.6926358413753296, "std": 0.3093153100062942, "bin": {}}, "signature_idxs": {"edge": [3053, 2641, 3145, 3073, 2932, 2441, 2530, 2401, 2470, 2552, 3156, 2999, 2572, 2633, 2945, 2432, 2476], "full": [1624, 1956, 2641, 1302, 2401, 2470, 2432, 2279, 2999, 2476, 2552, 784, 3145, 1924, 2441, 2206, 1225, 2030, 3156, 2251, 2633, 1700, 2945, 2572, 499, 3073, 2530, 3053, 2932]}}, "Regulation of glucokinase by glucokinase regulatory protein": {"direction": "dw", "overlap": {"value": 17, "mean": 9.191747572815531, "std": 5.165666138527258, "bin": {}}, "setsize": {"value": 27, "mean": 26.50728155339806, "std": 1.1564279570110754, "bin": {}}, "score": {"value": -3.036101665321186, "mean": -0.1342835103477938, "std": 0.9005781973200726, "bin": {}}, "pval": {"value": 0.0023965854126304, "mean": 0.6587239091779541, "std": 0.3228729436852376, "bin": {}}, "signature_idxs": {"edge": [3053, 2641, 3145, 3073, 2932, 2441, 2530, 2401, 2470, 2552, 3156, 2999, 2572, 2633, 2945, 2432, 2476], "full": [1956, 2641, 1302, 2401, 2470, 2432, 2279, 2999, 2476, 2552, 3145, 1924, 2441, 2206, 1225, 2030, 3156, 2251, 2633, 1700, 2945, 2572, 499, 3073, 2530, 3053, 2932]}}, "Sumoylation of sumoylation proteins": {"direction": "dw", "overlap": {"value": 17, "mean": 9.364077669902912, "std": 5.357461983681149, "bin": {}}, "setsize": {"value": 27, "mean": 26.98543689320388, "std": 1.422694542261493, "bin": {}}, "score": {"value": -3.036101665321186, "mean": -0.1342035149990308, "std": 0.8750751469170204, "bin": {}}, "pval": {"value": 0.0023965854126304, "mean": 0.667173865212816, "std": 0.3180062055057211, "bin": {}}, "signature_idxs": {"edge": [3053, 2641, 3145, 3073, 2932, 2441, 2530, 2401, 2470, 2552, 3156, 2999, 2572, 2633, 2945, 2432, 2476], "full": [1956, 2641, 1302, 2401, 2470, 2432, 2279, 2999, 2476, 2552, 3145, 1924, 2441, 2206, 1225, 2030, 3156, 2251, 2633, 1700, 2945, 2572, 499, 3073, 2530, 3053, 2932]}}, "Sumoylation of ubiquitinylation proteins": {"direction": "dw", "overlap": {"value": 17, "mean": 9.449029126213592, "std": 5.461233548653461, "bin": {}}, "setsize": {"value": 27, "mean": 27.453883495145632, "std": 1.7873094890722168, "bin": {}}, "score": {"value": -3.036101665321186, "mean": -0.1572884084685554, "std": 0.9014772608467888, "bin": {}}, "pval": {"value": 0.0023965854126304, "mean": 0.6545901700997189, "std": 0.3239621676727282, "bin": {}}, "signature_idxs": {"edge": [3053, 2641, 3145, 3073, 2932, 2441, 2530, 2401, 2470, 2552, 3156, 2999, 2572, 2633, 2945, 2432, 2476], "full": [1956, 2641, 1302, 2401, 2470, 2432, 2279, 2999, 2476, 2552, 3145, 1924, 2441, 2206, 1225, 2030, 3156, 2251, 2633, 1700, 2945, 2572, 499, 3073, 2530, 3053, 2932]}}, "Snrnp assembly": {"direction": "dw", "overlap": {"value": 20, "mean": 12.012135922330096, "std": 5.78475971431821, "bin": {}}, "setsize": {"value": 40, "mean": 39.9126213592233, "std": 1.7576838031275115, "bin": {}}, "score": {"value": -3.023673328987714, "mean": -0.4366913815612099, "std": 0.6796011329628798, "bin": {}}, "pval": {"value": 0.0024972593049457, "mean": 0.6606008910068464, "std": 0.3008282149965793, "bin": {}}, "signature_idxs": {"edge": [2441, 2552, 2436, 2432, 3114, 2470, 2999, 2633, 2476, 2945, 3145, 2530, 3156, 3053, 2641, 3175, 2932, 2401, 2572, 3073], "full": [1560, 1956, 2641, 1302, 2401, 2470, 2432, 2279, 2999, 1681, 2476, 725, 2552, 353, 1265, 1633, 3114, 3145, 2436, 1924, 2083, 2441, 2206, 1225, 2030, 3156, 2251, 1277, 2633, 1700, 2945, 2572, 3175, 499, 3073, 2530, 896, 3053, 1425, 2932]}}, "Trna aminoacylation": {"direction": "dw", "overlap": {"value": 26, "mean": 16.483009708737864, "std": 6.348855310777471, "bin": {}}, "setsize": {"value": 37, "mean": 35.58980582524272, "std": 1.9066039959172487, "bin": {}}, "score": {"value": -3.0163966289639377, "mean": -0.9220603626179013, "std": 1.038233561860114, "bin": {}}, "pval": {"value": 0.0025579841954246, "mean": 0.449939178371201, "std": 0.3622549439462865, "bin": {}}, "signature_idxs": {"edge": [3080, 2838, 2979, 2437, 2699, 2703, 2704, 2314, 2869, 2320, 2472, 2257, 2466, 2474, 2475, 3013, 2264, 2174, 2248, 2616, 2226, 3151, 2510, 2929, 2175, 2579], "full": [1201, 2226, 2314, 2466, 2616, 2320, 1306, 2699, 2472, 1445, 2703, 1128, 2510, 2474, 2475, 1173, 2704, 2437, 2078, 1586, 3013, 3151, 2174, 2838, 2175, 2248, 2869, 1465, 2257, 3080, 2929, 835, 2264, 2979, 1806, 590, 2579]}}, "Positive epigenetic regulation of rrna expression": {"direction": "dw", "overlap": {"value": 18, "mean": 14.16747572815534, "std": 5.601543687797506, "bin": {}}, "setsize": {"value": 28, "mean": 28.83495145631068, "std": 2.4449158159654645, "bin": {}}, "score": {"value": -3.012825798053685, "mean": -1.162471689203394, "std": 1.0574615836436132, "bin": {}}, "pval": {"value": 0.0025882744538185, "mean": 0.3493309276909624, "std": 0.3383903298109247, "bin": {}}, "signature_idxs": {"edge": [3067, 3016, 3051, 2407, 2803, 2718, 2581, 2741, 2585, 2586, 2906, 2566, 3180, 3120, 2427, 2499, 2452, 2459], "full": [2581, 2585, 3180, 2586, 957, 1484, 2499, 2906, 3067, 717, 2427, 679, 2803, 1685, 968, 2407, 3120, 633, 2718, 2566, 3051, 2741, 2452, 3016, 1517, 2263, 2265, 2459]}}, "Sumoylation of dna damage response and repair proteins": {"direction": "dw", "overlap": {"value": 25, "mean": 14.361650485436892, "std": 7.290290470205936, "bin": {}}, "setsize": {"value": 42, "mean": 43.529126213592235, "std": 4.579039011148904, "bin": {}}, "score": {"value": -3.0097120156408748, "mean": -0.4301449231131675, "std": 0.865716172169565, "bin": {}}, "pval": {"value": 0.0026149550126897, "mean": 0.6345117133747565, "std": 0.328082977476346, "bin": {}}, "signature_idxs": {"edge": [2805, 2441, 2552, 2835, 2432, 2206, 2326, 2470, 2251, 2999, 2633, 2385, 2476, 3073, 3145, 2358, 2530, 3156, 3053, 2641, 2932, 2401, 2572, 2945, 2279], "full": [1956, 2358, 2641, 1390, 1302, 1676, 2401, 2470, 1574, 1209, 2432, 2279, 2999, 2326, 2476, 2552, 3145, 1924, 1736, 2805, 2129, 2835, 2441, 2206, 1225, 1368, 2030, 3156, 2251, 2633, 1700, 2945, 2385, 738, 2572, 499, 3073, 2530, 3053, 2044, 2932, 1903]}}, "Viral messenger rna synthesis": {"direction": "dw", "overlap": {"value": 21, "mean": 11.220873786407768, "std": 6.355736741539839, "bin": {}}, "setsize": {"value": 36, "mean": 34.41747572815534, "std": 2.2908609982905, "bin": {}}, "score": {"value": -2.998426557615038, "mean": -0.2632815055090717, "std": 0.7751584621286535, "bin": {}}, "pval": {"value": 0.0027137755416677, "mean": 0.7082888325200691, "std": 0.3017066758535532, "bin": {}}, "signature_idxs": {"edge": [3075, 2441, 2552, 2432, 2832, 2470, 2999, 2633, 2476, 2945, 3145, 2530, 3156, 3053, 2909, 2641, 2932, 2401, 2572, 3073, 2799], "full": [1956, 3075, 2641, 1302, 919, 2832, 717, 2799, 1308, 556, 2401, 2470, 2432, 2279, 679, 2999, 2476, 2552, 2909, 3145, 1924, 2441, 2206, 1225, 2030, 3156, 2251, 2633, 1700, 2945, 2572, 499, 3073, 2530, 3053, 2932]}}, "Signaling by nuclear receptors": {"direction": "dw", "overlap": {"value": 19, "mean": 14.12621359223301, "std": 6.513137748659944, "bin": {}}, "setsize": {"value": 63, "mean": 58.25970873786408, "std": 6.38247204692112, "bin": {}}, "score": {"value": -2.997333604326454, "mean": -0.3252378984098789, "std": 0.6313974904868163, "bin": {}}, "pval": {"value": 0.0027235249373847, "mean": 0.6771403650140813, "std": 0.2900273735870928, "bin": {}}, "signature_idxs": {"edge": [3067, 2936, 3075, 2803, 2955, 2972, 2832, 3104, 3120, 2853, 3122, 2858, 2762, 3023, 3033, 2904, 2909, 3042, 2799], "full": [486, 2904, 506, 1433, 1624, 3075, 993, 2358, 1960, 1670, 185, 3122, 2853, 915, 750, 2614, 3033, 2936, 3023, 3042, 919, 3067, 2955, 2832, 717, 2799, 782, 2234, 1168, 2972, 1308, 529, 556, 1577, 2324, 1579, 679, 2858, 2909, 2803, 3104, 2514, 1685, 1830, 2016, 2127, 2285, 3120, 2129, 341, 1787, 1739, 1886, 1368, 279, 2762, 1933, 1893, 2188, 298, 667, 707, 1903]}}, "Cholesterol biosynthesis": {"direction": "up", "overlap": {"value": 5, "mean": 5.878640776699029, "std": 2.503362805703168, "bin": {"bin_hit": 1, "bin_50": 1, "bin_100": 3, "bin_250": 6, "bin_500": 7}}, "setsize": {"value": 18, "mean": 16.75, "std": 1.8986773628384943, "bin": {"bin_hit": 24, "bin_50": 24, "bin_100": 24, "bin_250": 24, "bin_500": 24}}, "score": {"value": 2.9909642144987862, "mean": 1.3996798653689082, "std": 1.0886216368414, "bin": {"bin_hit": 63.13664596273292, "bin_50": 9.170289855072465, "bin_100": 15.153383458646616, "bin_250": 13.677685950413224, "bin_500": 8.136134453781512}}, "pval": {"value": 0.0027809808100185, "mean": 0.2350718901934974, "std": 0.270950573691616, "bin": {"bin_hit": 0.0186828648017803, "bin_50": 0.1093006244161378, "bin_100": 0.0015052123544451, "bin_250": 1.8157657788138e-05, "bin_500": 0.0001050542030909}}, "signature_idxs": {"edge": [99, 4, 70, 141, 93], "full": [1564, 507, 2397, 1573, 99, 2511, 2516, 1641, 1320, 175, 1879, 1834, 70, 1880, 381, 93, 4, 141]}}, "Hcmv infection": {"direction": "dw", "overlap": {"value": 31, "mean": 14.00485436893204, "std": 6.684279174719419, "bin": {}}, "setsize": {"value": 54, "mean": 52.817961165048544, "std": 4.338623972998164, "bin": {}}, "score": {"value": -2.990539045876245, "mean": -0.2385386853821961, "std": 0.6896725732682144, "bin": {}}, "pval": {"value": 0.002784855233604, "mean": 0.6894872485949345, "std": 0.2915139648437624, "bin": {}}, "signature_idxs": {"edge": [2803, 2441, 2552, 2333, 2432, 2313, 2487, 2329, 2470, 2999, 2633, 2476, 2945, 3145, 2530, 3156, 2498, 2669, 3053, 2911, 2408, 2641, 2513, 2414, 2932, 3181, 2401, 2570, 2572, 3073, 2279], "full": [1956, 1530, 2498, 2641, 2313, 1441, 1302, 2401, 2470, 2432, 2279, 2999, 2476, 2552, 1921, 2803, 2513, 2329, 3145, 1214, 1924, 730, 969, 3181, 2333, 1319, 2408, 2911, 2441, 2206, 1225, 2030, 3156, 2251, 2633, 639, 1700, 2945, 2570, 566, 2572, 739, 499, 2414, 2487, 3073, 2530, 864, 283, 3053, 2669, 2932, 1294, 839]}}, "Synthesis of 5 eicosatetraenoic acids": {"direction": "up", "overlap": {"value": 0, "mean": 0.1728723404255319, "std": 0.3781368724963633, "bin": {"bin_hit": 1, "bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_hit": 3, "bin_50": 3, "bin_100": 3, "bin_250": 3, "bin_500": 3}}, "score": {"value": 2.990104137136384, "mean": 1.859021735804899, "std": 1.996381244471132, "bin": {"bin_hit": 727.5714285714286, "bin_50": 105.67708333333331, "bin_100": 52.04123711340206, "bin_250": 20.1336032388664, "bin_500": 9.775201612903226}}, "pval": {"value": 0.0027888235158415, "mean": 0.0562056781984062, "std": 0.1270418077334967, "bin": {"bin_hit": 0.0023522483882452, "bin_50": 0.014349642966783, "bin_100": 0.028561350265047, "bin_250": 0.0712161326093482, "bin_500": 0.1392345066023947}}, "signature_idxs": {"edge": [], "full": [10]}}, "Choline catabolism": {"direction": "dw", "overlap": {"value": 1, "mean": 0.9101941747572816, "std": 0.4613119336850514, "bin": {}}, "setsize": {"value": 1, "mean": 1.296116504854369, "std": 0.516414511406939, "bin": {}}, "score": {"value": -2.9847948138598195, "mean": -1.6165996630332595, "std": 1.7944375627524491, "bin": {}}, "pval": {"value": 0.0028376860257521, "mean": 0.146782453012119, "std": 0.2300685534210116, "bin": {}}, "signature_idxs": {"edge": [3188], "full": [3188]}}, "Scavenging by class b receptors": {"direction": "up", "overlap": {"value": 0, "mean": 0.145679012345679, "std": 0.366514912271715, "bin": {"bin_hit": 0, "bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0419753086419754, "std": 0.2005327457209575, "bin": {"bin_hit": 2, "bin_50": 2, "bin_100": 2, "bin_250": 2, "bin_500": 2}}, "score": {"value": 2.9776415528470044, "mean": 2.082821567211886, "std": 1.8633299667806096, "bin": {"bin_hit": 0.0, "bin_50": 211.375, "bin_100": 104.09278350515464, "bin_250": 40.27125506072875, "bin_500": 19.552419354838708}}, "pval": {"value": 0.0029047547717597, "mean": 0.0465602836219474, "std": 0.1224919585458108, "bin": {"bin_hit": 1.0, "bin_50": 0.0095889857469295, "bin_100": 0.0191317754164375, "bin_250": 0.0480572346493884, "bin_500": 0.0951177230364287}}, "signature_idxs": {"edge": [], "full": [18]}}, "Keratan sulfate biosynthesis": {"direction": "up", "overlap": {"value": 0, "mean": 0.4101941747572815, "std": 0.5946304728058994, "bin": {"bin_hit": 0, "bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.3349514563106797, "std": 0.6266273939490626, "bin": {"bin_hit": 11, "bin_50": 11, "bin_100": 11, "bin_250": 11, "bin_500": 11}}, "score": {"value": 2.944860089680973, "mean": 1.163530760409998, "std": 1.912288808565062, "bin": {"bin_hit": 0.0, "bin_50": 21.11875, "bin_100": 10.4, "bin_250": 4.023481781376519, "bin_500": 1.9534274193548389}}, "pval": {"value": 0.0032310073112307, "mean": 0.164014848011524, "std": 0.2357523358731849, "bin": {"bin_hit": 1.0, "bin_50": 0.0516364610584135, "bin_100": 0.1008375048293403, "bin_250": 0.2373820829012167, "bin_500": 0.4230365159515766}}, "signature_idxs": {"edge": [], "full": [39]}}, "Diseases associated with o glycosylation of proteins": {"direction": "up", "overlap": {"value": 0, "mean": 0.4174757281553398, "std": 0.5956846732906611, "bin": {"bin_hit": 0, "bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.5218446601941749, "std": 0.6129734113760651, "bin": {"bin_hit": 17, "bin_50": 17, "bin_100": 17, "bin_250": 17, "bin_500": 17}}, "score": {"value": 2.944860089680973, "mean": 0.9800294130852574, "std": 1.742276704521334, "bin": {"bin_hit": 0.0, "bin_50": 13.19140625, "bin_100": 6.496134020618556, "bin_250": 2.513157894736842, "bin_500": 1.2201360887096775}}, "pval": {"value": 0.0032310073112307, "mean": 0.2589966371269667, "std": 0.3065542429149289, "bin": {"bin_hit": 1.0, "bin_50": 0.0786913117950012, "bin_100": 0.1515272625734178, "bin_250": 0.3422564852890665, "bin_500": 0.5726791496550556}}, "signature_idxs": {"edge": [], "full": [39]}}, "Interactions of vpr with host cellular proteins": {"direction": "dw", "overlap": {"value": 20, "mean": 10.941747572815531, "std": 5.4248175535845045, "bin": {}}, "setsize": {"value": 34, "mean": 33.44174757281554, "std": 1.1901720746801605, "bin": {}}, "score": {"value": -2.933992123187892, "mean": -0.2027749306543701, "std": 0.9115358979979576, "bin": {}}, "pval": {"value": 0.0033463270049702, "mean": 0.6500206570215948, "std": 0.3218663131177026, "bin": {}}, "signature_idxs": {"edge": [2441, 2552, 3091, 2432, 2470, 2999, 2633, 2796, 2476, 2615, 3073, 3145, 2530, 3156, 3053, 2641, 2932, 2401, 2572, 2945], "full": [1956, 2796, 3091, 2641, 1161, 527, 751, 1302, 2615, 2401, 2470, 2432, 2279, 510, 2999, 2476, 2552, 3145, 1924, 2441, 2206, 1225, 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"mean": 0.2583732057416268, "std": 0.4377402109658441, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_hit": 8, "bin_50": 8, "bin_100": 8, "bin_250": 8, "bin_500": 8}}, "score": {"value": 2.9229517136079446, "mean": 1.251695468241205, "std": 2.25806897109107, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 14.86156111929308, "bin_250": 5.749566223250434, "bin_500": 2.7914746543778803}}, "pval": {"value": 0.0034673028204692, "mean": 0.0890098072663544, "std": 0.1746954164622726, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 0.0743799864466655, "bin_250": 0.1788587842302525, "bin_500": 0.3296279245345712}}, "signature_idxs": {"edge": [], "full": [53]}}, "Hydrolysis of lpc": {"direction": "up", "overlap": {"value": 0, "mean": 0.1913265306122449, "std": 0.3933455088038081, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, 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0.7901234567901234, "std": 0.7522156471518984, "bin": {"bin_hit": 0, "bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 2.237037037037037, "std": 0.7653683764793772, "bin": {"bin_hit": 12, "bin_50": 12, "bin_100": 12, "bin_250": 12, "bin_500": 12}}, "score": {"value": 2.7779069099467693, "mean": 1.1136905237616417, "std": 1.291303912107451, "bin": {"bin_hit": 0.0, "bin_50": 0.0, "bin_100": 0.0, "bin_250": 3.6573426573426575, "bin_500": 1.7756598240469208}}, "pval": {"value": 0.0054710289805028, "mean": 0.2852934551021182, "std": 0.2805694594942842, "bin": {"bin_hit": 1.0, "bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.2559514735144251, "bin_500": 0.4511907478135378}}, "signature_idxs": {"edge": [], "full": [145]}}, "Ub specific processing proteases": {"direction": "up", "overlap": {"value": 22, "mean": 17.070388349514563, "std": 9.734454714417684, "bin": {"bin_hit": 0, "bin_50": 5, "bin_100": 7, "bin_250": 13, "bin_500": 23}}, "setsize": {"value": 78, 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"bin_250": 8, "bin_500": 13}}, "setsize": {"value": 50, "mean": 48.63834951456311, "std": 2.025992551710678, "bin": {"bin_hit": 77, "bin_50": 77, "bin_100": 77, "bin_250": 77, "bin_500": 77}}, "score": {"value": 2.0394105679636554, "mean": 0.4830095996380346, "std": 1.2813542829769398, "bin": {"bin_hit": 0.0, "bin_50": 8.877497062279671, "bin_100": 7.486559139784946, "bin_250": 4.772463768115942, "bin_500": 4.043614411157025}}, "pval": {"value": 0.0414090685733201, "mean": 0.5534777326316677, "std": 0.3757731368449524, "bin": {"bin_hit": 1.0, "bin_50": 0.0059462173176447, "bin_100": 0.0008465768608115, "bin_250": 0.00054101826865, "bin_500": 7.84116161102813e-05}}, "signature_idxs": {"edge": [352, 167, 8, 105, 417, 20, 338, 119, 55, 441, 30, 95], "full": [525, 2356, 1907, 2050, 1993, 417, 913, 1916, 95, 1675, 2467, 119, 2162, 2468, 2400, 55, 20, 105, 1536, 1537, 720, 2996, 2998, 1261, 338, 1446, 8, 352, 3068, 2512, 30, 478, 1631, 2434, 2802, 1266, 2016, 729, 1545, 2478, 3120, 1584, 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"bin_50": 16.31030303030303, "bin_100": 10.0, "bin_250": 7.454560669456067, "bin_500": 3.5590573770491805}}, "pval": {"value": 0.0450569000283227, "mean": 0.1874419874946837, "std": 0.2901223460226844, "bin": {"bin_hit": 1.0, "bin_50": 0.0001764406413441, "bin_100": 0.0002457945313068, "bin_250": 1.120343948585762e-05, "bin_500": 0.0020586259473287}}, "signature_idxs": {"edge": [32, 166, 169, 142, 17, 84, 24, 26], "full": [169, 711, 17, 3065, 2541, 3084, 1160, 2728, 1388, 1962, 651, 3041, 527, 751, 26, 2779, 3118, 2621, 855, 166, 205, 2560, 84, 142, 2811, 32, 2985, 2668, 24, 1291, 1025, 1198, 1476, 2393, 802]}}, "Detoxification of reactive oxygen species": {"direction": "dw", "overlap": {"value": 6, "mean": 4.444174757281553, "std": 2.0560802675351155, "bin": {}}, "setsize": {"value": 9, "mean": 10.019417475728156, "std": 0.8270967180770472, "bin": {}}, "score": {"value": -2.00153427432931, "mean": -0.6490446793765532, "std": 0.7836320322231982, "bin": {}}, "pval": {"value": 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