{"signature": {"size": 3216, "values": [["P42566", 5.6782294668488875], ["Q9Y6E2", 5.070865592408463], ["Q8TDB6", 4.985329119564522], ["B2RBV5", 3.9017047268379406], ["Q9Y3D8", 3.5789989179374713], ["Q96DE0", 3.3403238824336476], ["Q9NQT8", 3.3403238824336476], ["P08134", 3.182814480030893], ["P47755", 3.104544005085612], ["Q9NWV8", 3.104544005085612], ["Q53EL6", 3.0265972675657657], ["Q6UWP2", 3.0265972675657657], ["Q96B36", 3.0265972675657657], ["Q9NRY5", 3.0265972675657657], ["Q9UKG1", 3.0265972675657657], ["P40222", 2.9489749647108976], ["Q5W0B1", 2.9489749647108976], ["Q9BYN0", 2.9489749647108976], ["O94903", 2.8716777997035905], ["Q2VPK5", 2.8716777997035905], ["O60294", 2.794706481758439], ["P35244", 2.794706481758439], ["Q05639", 2.794706481758439], ["Q96EA4", 2.794706481758439], ["Q6UVJ0", 2.718061726212978], ["Q9H910", 2.718061726212978], ["O00233", 2.641744254620556], ["P09132", 2.641744254620556], ["P42575", 2.641744254620556], ["Q9BYD3", 2.641744254620556], ["O43488", 2.565754794845238], ["P62942", 2.565754794845238], ["Q9H4H8", 2.565754794845238], ["P04080", 2.4900940811588], ["P16333", 2.4900940811588], ["Q2TAA2", 2.4900940811588], ["Q96EN8", 2.4900940811588], ["Q9H6Z4", 2.4900940811588], ["A6NDG6", 2.4147628543398456], ["O76071", 2.339761861775142], ["P57081", 2.339761861775142], ["P78417", 2.339761861775142], ["Q99805", 2.339761861775142], ["P10412", 2.265091857563218], ["Q96G46", 2.265091857563218], ["Q9H2D1", 2.265091857563218], ["Q9UBI1", 2.265091857563218], ["P60174", 2.190753602620293], ["P62847", 2.190753602620293], ["Q00688", 2.190753602620293], ["Q99504", 2.190753602620293], ["Q9H0U4", 2.190753602620293], ["Q9NUQ3", 2.190753602620293], ["P30086", 2.116747864788611], ["P57076", 2.116747864788611], ["Q13190", 2.116747864788611], ["Q14147", 2.116747864788611], ["Q6AI08", 2.116747864788611], ["Q7L266", 2.116747864788611], ["Q96FW1", 2.116747864788611], ["Q9BPZ3", 2.116747864788611], ["Q9UJC3", 2.116747864788611], ["Q9UL46", 2.116747864788611], ["O76003", 2.043075418947249], ["P23634", 2.043075418947249], ["P46109", 2.043075418947249], ["P49760", 2.043075418947249], ["Q15366", 2.043075418947249], ["Q15404", 2.043075418947249], ["Q15906", 2.043075418947249], ["Q5VUJ6", 2.043075418947249], ["Q92530", 2.043075418947249], ["Q93074", 2.043075418947249], ["Q96GA3", 2.043075418947249], ["Q96IU4", 2.043075418947249], ["Q9NVZ3", 2.043075418947249], ["Q9Y315", 2.043075418947249], ["Q9Y4P1", 2.043075418947249], ["O14727", 1.9697370471254692], ["P30043", 1.9697370471254692], ["Q12800", 1.9697370471254692], ["Q13126", 1.9697370471254692], ["Q9BTY7", 1.9697370471254692], ["O76075", 1.8967335386186992], ["P05388", 1.8967335386186992], ["P33908", 1.8967335386186992], ["P42766", 1.8967335386186992], ["P50542", 1.8967335386186992], ["P52788", 1.8967335386186992], ["Q01658", 1.8967335386186992], ["Q14149", 1.8967335386186992], ["Q8WVJ2", 1.8967335386186992], ["Q969T9", 1.8967335386186992], ["Q99497", 1.8967335386186992], ["Q9NS86", 1.8967335386186992], ["Q9NVQ4", 1.8967335386186992], ["Q9NXR7", 1.8967335386186992], ["Q9P016", 1.8967335386186992], ["O95376", 1.824065690107215], ["P41227", 1.824065690107215], ["P49593", 1.824065690107215], ["P51858", 1.824065690107215], ["P52294", 1.824065690107215], ["P61088", 1.824065690107215], ["P62081", 1.824065690107215], ["Q15365", 1.824065690107215], ["Q96GG9", 1.824065690107215], ["Q99961", 1.824065690107215], ["Q9BQ61", 1.824065690107215], ["Q9BU89", 1.824065690107215], ["Q9H4A6", 1.824065690107215], ["Q9NVG8", 1.824065690107215], ["Q9Y2Z2", 1.824065690107215], ["O43670", 1.7517343057776045], ["P04075", 1.7517343057776045], ["P25787", 1.7517343057776045], ["Q06124", 1.7517343057776045], ["Q13614", 1.7517343057776045], ["Q96CP2", 1.7517343057776045], ["Q9BRX5", 1.7517343057776045], ["Q9NZL4", 1.7517343057776045], ["Q9UBP6", 1.7517343057776045], ["Q9UQ13", 1.7517343057776045], ["A6NDU8", 1.6797401974471151], ["O00442", 1.6797401974471151], ["O14981", 1.6797401974471151], ["O43598", 1.6797401974471151], ["O75935", 1.6797401974471151], ["O95340", 1.6797401974471151], ["P13797", 1.6797401974471151], ["P39748", 1.6797401974471151], ["P49643", 1.6797401974471151], ["P54578", 1.6797401974471151], ["P62910", 1.6797401974471151], ["Q14353", 1.6797401974471151], ["Q15833", 1.6797401974471151], ["Q6SZW1", 1.6797401974471151], ["Q86TI2", 1.6797401974471151], ["Q96BT7", 1.6797401974471151], ["Q96KB5", 1.6797401974471151], ["Q96RU2", 1.6797401974471151], ["Q99439", 1.6797401974471151], ["Q9BQA1", 1.6797401974471151], ["Q9BUF5", 1.6797401974471151], ["Q9BV20", 1.6797401974471151], ["Q9H7D7", 1.6797401974471151], ["Q9NWZ8", 1.6797401974471151], ["Q9NXF7", 1.6797401974471151], ["P00568", 1.6080841846909468], ["P15170", 1.6080841846909468], ["P47914", 1.6080841846909468], ["P61289", 1.6080841846909468], ["P62314", 1.6080841846909468], ["P84098", 1.6080841846909468], ["Q13144", 1.6080841846909468], ["Q13243", 1.6080841846909468], ["Q14CX7", 1.6080841846909468], ["Q15437", 1.6080841846909468], ["Q16555", 1.6080841846909468], ["Q5TFE4", 1.6080841846909468], ["Q7Z6M1", 1.6080841846909468], ["Q8NC51", 1.6080841846909468], ["Q8WVB6", 1.6080841846909468], ["Q9C0B1", 1.6080841846909468], ["Q9H944", 1.6080841846909468], ["Q9NWY4", 1.6080841846909468], ["Q9UJU6", 1.6080841846909468], ["Q9Y6W5", 1.6080841846909468], ["O14530", 1.5367670949726053], ["O43237", 1.5367670949726053], ["O43708", 1.5367670949726053], ["O95861", 1.5367670949726053], ["P24534", 1.5367670949726053], ["P27695", 1.5367670949726053], ["P28161", 1.5367670949726053], ["P49903", 1.5367670949726053], ["P57737", 1.5367670949726053], ["P58546", 1.5367670949726053], ["P61758", 1.5367670949726053], ["P62333", 1.5367670949726053], ["P62841", 1.5367670949726053], ["P63208", 1.5367670949726053], ["Q14160", 1.5367670949726053], ["Q5T6V5", 1.5367670949726053], ["Q6GQQ9", 1.5367670949726053], ["Q7L1Q6", 1.5367670949726053], ["Q8IZD4", 1.5367670949726053], ["Q8WUX2", 1.5367670949726053], ["Q92796", 1.5367670949726053], ["Q92888", 1.5367670949726053], ["Q96BN8", 1.5367670949726053], ["Q96JB2", 1.5367670949726053], ["Q9H2H8", 1.5367670949726053], ["Q9P253", 1.5367670949726053], ["Q9UJY4", 1.5367670949726053], ["O00764", 1.4657897637774124], ["O43324", 1.4657897637774124], ["O75175", 1.4657897637774124], ["O75794", 1.4657897637774124], ["O95394", 1.4657897637774124], ["O95801", 1.4657897637774124], ["P12931", 1.4657897637774124], ["P55735", 1.4657897637774124], ["P78346", 1.4657897637774124], ["Q14999", 1.4657897637774124], ["Q5TDH0", 1.4657897637774124], ["Q86W50", 1.4657897637774124], ["Q8NBF2", 1.4657897637774124], ["Q99426", 1.4657897637774124], ["Q99986", 1.4657897637774124], ["Q9BZG1", 1.4657897637774124], ["Q9HAS0", 1.4657897637774124], ["Q9NPF4", 1.4657897637774124], ["Q9UBE0", 1.4657897637774124], ["Q9UMY4", 1.4657897637774124], ["Q9Y3Z3", 1.4657897637774124], ["Q9Y617", 1.4657897637774124], ["O15498", 1.3951530347492413], ["O60493", 1.3951530347492413], ["P07948", 1.3951530347492413], ["P10644", 1.3951530347492413], ["P15531", 1.3951530347492413], ["P19623", 1.3951530347492413], ["P21266", 1.3951530347492413], ["P25789", 1.3951530347492413], ["P28074", 1.3951530347492413], ["P46778", 1.3951530347492413], ["P49720", 1.3951530347492413], ["P49915", 1.3951530347492413], ["P52565", 1.3951530347492413], ["P55210", 1.3951530347492413], ["P61970", 1.3951530347492413], ["P63172", 1.3951530347492413], ["Q00536", 1.3951530347492413], ["Q08379", 1.3951530347492413], ["Q13596", 1.3951530347492413], ["Q13885", 1.3951530347492413], ["Q15633", 1.3951530347492413], ["Q8IZ83", 1.3951530347492413], ["Q8NB46", 1.3951530347492413], ["Q96GX5", 1.3951530347492413], ["Q99816", 1.3951530347492413], ["Q9BWJ5", 1.3951530347492413], ["Q9H299", 1.3951530347492413], ["Q9NY33", 1.3951530347492413], ["Q9Y2T2", 1.3951530347492413], ["A3KN83", 1.324857759830634], ["O00154", 1.324857759830634], ["O14929", 1.324857759830634], ["O43252", 1.324857759830634], ["O75648", 1.324857759830634], ["P09429", 1.324857759830634], ["P12004", 1.324857759830634], ["P12268", 1.324857759830634], ["P25325", 1.324857759830634], ["P43490", 1.324857759830634], ["P51452", 1.324857759830634], ["P53999", 1.324857759830634], ["Q06323", 1.324857759830634], ["Q13951", 1.324857759830634], ["Q14181", 1.324857759830634], ["Q15417", 1.324857759830634], ["Q16630", 1.324857759830634], ["Q6P1R4", 1.324857759830634], ["Q6PD74", 1.324857759830634], ["Q6ZRI6", 1.324857759830634], ["Q86UE8", 1.324857759830634], ["Q8NCW5", 1.324857759830634], ["Q8WUX9", 1.324857759830634], ["Q96DE5", 1.324857759830634], ["Q96FJ2", 1.324857759830634], ["Q9BRT9", 1.324857759830634], ["Q9BWH6", 1.324857759830634], ["Q9BWT6", 1.324857759830634], ["Q9GZN8", 1.324857759830634], ["Q9H0C8", 1.324857759830634], ["Q9P287", 1.324857759830634], ["Q9UI30", 1.324857759830634], ["Q9Y312", 1.324857759830634], ["Q9Y383", 1.324857759830634], ["Q9Y3C4", 1.324857759830634], ["Q9Y547", 1.324857759830634], ["Q9Y613", 1.324857759830634], ["O00161", 1.254904799406343], ["O14579", 1.254904799406343], ["O14772", 1.254904799406343], ["O15347", 1.254904799406343], ["O60678", 1.254904799406343], ["O60888", 1.254904799406343], ["O75155", 1.254904799406343], ["O94992", 1.254904799406343], ["O95336", 1.254904799406343], ["P40937", 1.254904799406343], ["P46782", 1.254904799406343], ["P48643", 1.254904799406343], ["P52594", 1.254904799406343], ["P52907", 1.254904799406343], ["P55036", 1.254904799406343], ["P62195", 1.254904799406343], ["P62424", 1.254904799406343], ["P62899", 1.254904799406343], ["P63244", 1.254904799406343], ["P68371", 1.254904799406343], ["P78559", 1.254904799406343], ["Q02750", 1.254904799406343], ["Q13418", 1.254904799406343], ["Q2NKX8", 1.254904799406343], ["Q2NL82", 1.254904799406343], ["Q5T447", 1.254904799406343], ["Q7Z7L1", 1.254904799406343], ["Q96A49", 1.254904799406343], ["Q96FZ2", 1.254904799406343], ["Q96G23", 1.254904799406343], ["Q9BSD7", 1.254904799406343], ["Q9BTE7", 1.254904799406343], ["Q9H074", 1.254904799406343], ["Q9H8M7", 1.254904799406343], ["Q9P258", 1.254904799406343], ["Q9UBV8", 1.254904799406343], ["Q9Y224", 1.254904799406343], ["Q9Y3T6", 1.254904799406343], ["O00299", 1.1852950224504775], ["O15355", 1.1852950224504775], ["O43684", 1.1852950224504775], ["O60524", 1.1852950224504775], ["O60547", 1.1852950224504775], ["P07741", 1.1852950224504775], ["P08397", 1.1852950224504775], ["P13798", 1.1852950224504775], ["P35249", 1.1852950224504775], ["P50336", 1.1852950224504775], ["P52888", 1.1852950224504775], ["P85037", 1.1852950224504775], ["Q08J23", 1.1852950224504775], ["Q13232", 1.1852950224504775], ["Q13325", 1.1852950224504775], ["Q15181", 1.1852950224504775], ["Q16637", 1.1852950224504775], ["Q6NZY4", 1.1852950224504775], ["Q7KZI7", 1.1852950224504775], ["Q86WB0", 1.1852950224504775], ["Q8N0X7", 1.1852950224504775], ["Q8NFG4", 1.1852950224504775], ["Q8TBC4", 1.1852950224504775], ["Q96MG7", 1.1852950224504775], ["Q9BZX2", 1.1852950224504775], ["Q9H0R4", 1.1852950224504775], ["Q9H773", 1.1852950224504775], ["Q9H974", 1.1852950224504775], ["Q9NR50", 1.1852950224504775], ["Q9NXG2", 1.1852950224504775], ["Q9UHD1", 1.1852950224504775], ["Q9UN37", 1.1852950224504775], ["Q9Y680", 1.1852950224504775], ["Q9Y696", 1.1852950224504775], ["O00213", 1.1160293066773117], ["O00273", 1.1160293066773117], ["O14757", 1.1160293066773117], ["O95865", 1.1160293066773117], ["P06730", 1.1160293066773117], ["P09972", 1.1160293066773117], ["P12277", 1.1160293066773117], ["P18615", 1.1160293066773117], ["P18669", 1.1160293066773117], ["P19784", 1.1160293066773117], ["P20585", 1.1160293066773117], ["P23919", 1.1160293066773117], ["P26641", 1.1160293066773117], ["P32119", 1.1160293066773117], ["P35250", 1.1160293066773117], ["P35998", 1.1160293066773117], ["P36543", 1.1160293066773117], ["P37837", 1.1160293066773117], ["P43686", 1.1160293066773117], ["P45974", 1.1160293066773117], ["P49773", 1.1160293066773117], ["P50990", 1.1160293066773117], ["P62070", 1.1160293066773117], ["P78362", 1.1160293066773117], ["P83731", 1.1160293066773117], ["Q06546", 1.1160293066773117], ["Q13309", 1.1160293066773117], ["Q14202", 1.1160293066773117], ["Q16186", 1.1160293066773117], ["Q5SW79", 1.1160293066773117], ["Q8N6T3", 1.1160293066773117], ["Q96C23", 1.1160293066773117], ["Q96M27", 1.1160293066773117], ["Q96SB4", 1.1160293066773117], ["Q9BY32", 1.1160293066773117], ["Q9H0B6", 1.1160293066773117], ["Q9H3P2", 1.1160293066773117], ["Q9HC38", 1.1160293066773117], ["Q9NPQ8", 1.1160293066773117], ["Q9NW82", 1.1160293066773117], ["Q9UBQ5", 1.1160293066773117], ["Q9Y697", 1.1160293066773117], ["O00192", 1.0471085386959165], ["O75575", 1.0471085386959165], ["O95433", 1.0471085386959165], ["P00338", 1.0471085386959165], ["P04350", 1.0471085386959165], ["P07437", 1.0471085386959165], ["P14174", 1.0471085386959165], ["P14324", 1.0471085386959165], ["P15880", 1.0471085386959165], ["P17655", 1.0471085386959165], ["P25788", 1.0471085386959165], ["P36915", 1.0471085386959165], ["P40763", 1.0471085386959165], ["P46926", 1.0471085386959165], ["P48147", 1.0471085386959165], ["P50914", 1.0471085386959165], ["P52209", 1.0471085386959165], ["P55212", 1.0471085386959165], ["P62330", 1.0471085386959165], ["P62753", 1.0471085386959165], ["Q13685", 1.0471085386959165], ["Q14232", 1.0471085386959165], ["Q15555", 1.0471085386959165], ["Q5PRF9", 1.0471085386959165], ["Q69YN2", 1.0471085386959165], ["Q7Z4G4", 1.0471085386959165], ["Q86UK7", 1.0471085386959165], ["Q86WJ1", 1.0471085386959165], ["Q8IV48", 1.0471085386959165], ["Q8N1G4", 1.0471085386959165], ["Q8TD19", 1.0471085386959165], ["Q8TF05", 1.0471085386959165], ["Q96C86", 1.0471085386959165], ["Q96EK7", 1.0471085386959165], ["Q99873", 1.0471085386959165], ["Q9BQC3", 1.0471085386959165], ["Q9BUI4", 1.0471085386959165], ["Q9BW83", 1.0471085386959165], ["Q9C0C9", 1.0471085386959165], ["Q9H3K6", 1.0471085386959165], ["Q9NP79", 1.0471085386959165], ["Q9NUQ8", 1.0471085386959165], ["Q9NWV4", 1.0471085386959165], ["Q9UDW1", 1.0471085386959165], ["Q9UID3", 1.0471085386959165], ["Q9UKS6", 1.0471085386959165], ["Q9UNS2", 1.0471085386959165], ["Q9Y265", 1.0471085386959165], ["Q9Y570", 1.0471085386959165], ["Q9Y5N5", 1.0471085386959165], ["O60256", 0.9785336141687129], ["O60828", 0.9785336141687129], ["O75718", 0.9785336141687129], ["O75822", 0.9785336141687129], ["O94782", 0.9785336141687129], ["O95456", 0.9785336141687129], ["O95747", 0.9785336141687129], ["P00492", 0.9785336141687129], ["P13489", 0.9785336141687129], ["P18621", 0.9785336141687129], ["P26373", 0.9785336141687129], ["P28072", 0.9785336141687129], ["P30046", 0.9785336141687129], ["P30419", 0.9785336141687129], ["P31146", 0.9785336141687129], ["P34932", 0.9785336141687129], ["P43246", 0.9785336141687129], ["P46779", 0.9785336141687129], ["P47756", 0.9785336141687129], ["P49368", 0.9785336141687129], ["P60520", 0.9785336141687129], ["P60866", 0.9785336141687129], ["P61927", 0.9785336141687129], ["P62249", 0.9785336141687129], ["P62266", 0.9785336141687129], ["P63241", 0.9785336141687129], ["P68402", 0.9785336141687129], ["P84085", 0.9785336141687129], ["Q07866", 0.9785336141687129], ["Q14527", 0.9785336141687129], ["Q15370", 0.9785336141687129], ["Q3B7T1", 0.9785336141687129], ["Q7Z2K8", 0.9785336141687129], ["Q7Z6J8", 0.9785336141687129], ["Q8IZ69", 0.9785336141687129], ["Q8TBB5", 0.9785336141687129], ["Q92597", 0.9785336141687129], ["Q969T7", 0.9785336141687129], ["Q96D46", 0.9785336141687129], ["Q96EB1", 0.9785336141687129], ["Q96EY8", 0.9785336141687129], ["Q96RS6", 0.9785336141687129], ["Q9BTE3", 0.9785336141687129], ["Q9BUP3", 0.9785336141687129], ["Q9BWD1", 0.9785336141687129], ["Q9H6S0", 0.9785336141687129], ["Q9HB71", 0.9785336141687129], ["Q9HC35", 0.9785336141687129], ["Q9NPE3", 0.9785336141687129], ["Q9NQ88", 0.9785336141687129], ["Q9NWS0", 0.9785336141687129], ["Q9P2N6", 0.9785336141687129], ["Q9UBQ7", 0.9785336141687129], ["Q9UNF1", 0.9785336141687129], ["Q9Y3F4", 0.9785336141687129], ["Q9Y3I0", 0.9785336141687129], ["Q9Y5K5", 0.9785336141687129], ["Q9Y5X1", 0.9785336141687129], ["Q9Y6I3", 0.9785336141687129], ["O43175", 0.9103054379741008], ["O43809", 0.9103054379741008], ["O60346", 0.9103054379741008], ["O75608", 0.9103054379741008], ["O95817", 0.9103054379741008], ["P06493", 0.9103054379741008], ["P08237", 0.9103054379741008], ["P23396", 0.9103054379741008], ["P28066", 0.9103054379741008], ["P28070", 0.9103054379741008], ["P28482", 0.9103054379741008], ["P30085", 0.9103054379741008], ["P31150", 0.9103054379741008], ["P31350", 0.9103054379741008], ["P36871", 0.9103054379741008], ["P42224", 0.9103054379741008], ["P46821", 0.9103054379741008], ["P48637", 0.9103054379741008], ["P49591", 0.9103054379741008], ["P49770", 0.9103054379741008], ["P51665", 0.9103054379741008], ["P60900", 0.9103054379741008], ["P63151", 0.9103054379741008], ["P63220", 0.9103054379741008], ["P78371", 0.9103054379741008], ["Q00535", 0.9103054379741008], ["Q12765", 0.9103054379741008], ["Q13451", 0.9103054379741008], ["Q13526", 0.9103054379741008], ["Q13546", 0.9103054379741008], ["Q14331", 0.9103054379741008], ["Q15645", 0.9103054379741008], ["Q15691", 0.9103054379741008], ["Q4KMP7", 0.9103054379741008], ["Q52LJ0", 0.9103054379741008], ["Q6IA86", 0.9103054379741008], ["Q6NXE6", 0.9103054379741008], ["Q71SY5", 0.9103054379741008], ["Q8IWR0", 0.9103054379741008], ["Q92945", 0.9103054379741008], ["Q96CX2", 0.9103054379741008], ["Q96DY7", 0.9103054379741008], ["Q99627", 0.9103054379741008], ["Q99956", 0.9103054379741008], ["Q9BRJ7", 0.9103054379741008], ["Q9BT78", 0.9103054379741008], ["Q9BTT0", 0.9103054379741008], ["Q9H4A4", 0.9103054379741008], ["Q9H4M9", 0.9103054379741008], ["Q9H814", 0.9103054379741008], ["Q9H993", 0.9103054379741008], ["Q9HB07", 0.9103054379741008], ["Q9HD26", 0.9103054379741008], ["Q9NRF8", 0.9103054379741008], ["Q9NX46", 0.9103054379741008], ["Q9UNN5", 0.9103054379741008], ["Q9UPT9", 0.9103054379741008], ["Q9Y230", 0.9103054379741008], ["Q9Y2Z0", 0.9103054379741008], ["Q9Y3U8", 0.9103054379741008], ["Q9Y6M7", 0.9103054379741008], ["O00151", 0.8424249243732836], ["O00232", 0.8424249243732836], ["O43719", 0.8424249243732836], ["O43929", 0.8424249243732836], ["O60826", 0.8424249243732836], ["O75083", 0.8424249243732836], ["O75436", 0.8424249243732836], ["O75446", 0.8424249243732836], ["O75874", 0.8424249243732836], ["O94842", 0.8424249243732836], ["O95400", 0.8424249243732836], ["O95487", 0.8424249243732836], ["O95551", 0.8424249243732836], ["O95983", 0.8424249243732836], ["P05198", 0.8424249243732836], ["P13591", 0.8424249243732836], ["P14735", 0.8424249243732836], ["P15104", 0.8424249243732836], ["P18085", 0.8424249243732836], ["P22102", 0.8424249243732836], ["P22681", 0.8424249243732836], ["P23526", 0.8424249243732836], ["P24941", 0.8424249243732836], ["P25786", 0.8424249243732836], ["P27694", 0.8424249243732836], ["P30041", 0.8424249243732836], ["P30520", 0.8424249243732836], ["P34949", 0.8424249243732836], ["P35237", 0.8424249243732836], ["P40855", 0.8424249243732836], ["P41240", 0.8424249243732836], ["P41250", 0.8424249243732836], ["P50395", 0.8424249243732836], ["P51570", 0.8424249243732836], ["P62244", 0.8424249243732836], ["P62854", 0.8424249243732836], ["P62877", 0.8424249243732836], ["P62913", 0.8424249243732836], ["P62917", 0.8424249243732836], ["Q01081", 0.8424249243732836], ["Q07864", 0.8424249243732836], ["Q13561", 0.8424249243732836], ["Q16204", 0.8424249243732836], ["Q16222", 0.8424249243732836], ["Q6PKG0", 0.8424249243732836], ["Q7Z2T5", 0.8424249243732836], ["Q8IX90", 0.8424249243732836], ["Q8IY67", 0.8424249243732836], ["Q8N0Z6", 0.8424249243732836], ["Q8N6R0", 0.8424249243732836], ["Q8WX92", 0.8424249243732836], ["Q92759", 0.8424249243732836], ["Q93100", 0.8424249243732836], ["Q96CN7", 0.8424249243732836], ["Q96CS2", 0.8424249243732836], ["Q96IJ6", 0.8424249243732836], ["Q96KC8", 0.8424249243732836], ["Q96MX6", 0.8424249243732836], ["Q99700", 0.8424249243732836], ["Q9BRF8", 0.8424249243732836], ["Q9BW61", 0.8424249243732836], ["Q9C0D3", 0.8424249243732836], ["Q9H6T3", 0.8424249243732836], ["Q9NQW7", 0.8424249243732836], ["Q9NR45", 0.8424249243732836], ["Q9NTK5", 0.8424249243732836], ["Q9NUQ9", 0.8424249243732836], ["Q9NVM6", 0.8424249243732836], ["Q9NZ08", 0.8424249243732836], ["Q9UHB9", 0.8424249243732836], ["Q9UIV1", 0.8424249243732836], ["Q9ULC4", 0.8424249243732836], ["Q9Y294", 0.8424249243732836], ["Q9Y3C8", 0.8424249243732836], ["Q9Y520", 0.8424249243732836], ["O14531", 0.7748929971814376], ["O15258", 0.7748929971814376], ["O43399", 0.7748929971814376], ["O43583", 0.7748929971814376], ["O60343", 0.7748929971814376], ["O60664", 0.7748929971814376], ["O60684", 0.7748929971814376], ["O60701", 0.7748929971814376], ["O75223", 0.7748929971814376], ["O75832", 0.7748929971814376], ["O96013", 0.7748929971814376], ["P04183", 0.7748929971814376], ["P04406", 0.7748929971814376], ["P05455", 0.7748929971814376], ["P08865", 0.7748929971814376], ["P11142", 0.7748929971814376], ["P11172", 0.7748929971814376], ["P13984", 0.7748929971814376], ["P15121", 0.7748929971814376], ["P17858", 0.7748929971814376], ["P17987", 0.7748929971814376], ["P26583", 0.7748929971814376], ["P29218", 0.7748929971814376], ["P30153", 0.7748929971814376], ["P31153", 0.7748929971814376], ["P31939", 0.7748929971814376], ["P35270", 0.7748929971814376], ["P37198", 0.7748929971814376], ["P41091", 0.7748929971814376], ["P41214", 0.7748929971814376], ["P42574", 0.7748929971814376], ["P43121", 0.7748929971814376], ["P49006", 0.7748929971814376], ["P53680", 0.7748929971814376], ["P55072", 0.7748929971814376], ["P59998", 0.7748929971814376], ["P61081", 0.7748929971814376], ["P62277", 0.7748929971814376], ["P62861", 0.7748929971814376], ["P62888", 0.7748929971814376], ["Q02790", 0.7748929971814376], ["Q06203", 0.7748929971814376], ["Q15003", 0.7748929971814376], ["Q15650", 0.7748929971814376], ["Q16658", 0.7748929971814376], ["Q5VW32", 0.7748929971814376], ["Q6IBS0", 0.7748929971814376], ["Q86UY6", 0.7748929971814376], ["Q86WR0", 0.7748929971814376], ["Q8TCD5", 0.7748929971814376], ["Q8WU90", 0.7748929971814376], ["Q8WUB8", 0.7748929971814376], ["Q92600", 0.7748929971814376], ["Q96A35", 0.7748929971814376], ["Q96DG6", 0.7748929971814376], ["Q96PZ0", 0.7748929971814376], ["Q96T60", 0.7748929971814376], ["Q99622", 0.7748929971814376], ["Q9BQ67", 0.7748929971814376], ["Q9H2P9", 0.7748929971814376], ["Q9H6D7", 0.7748929971814376], ["Q9H9A6", 0.7748929971814376], ["Q9HCG8", 0.7748929971814376], ["Q9NQR4", 0.7748929971814376], ["Q9NVD7", 0.7748929971814376], ["Q9NWU1", 0.7748929971814376], ["Q9NX74", 0.7748929971814376], ["Q9NYY8", 0.7748929971814376], ["Q9NZL9", 0.7748929971814376], ["Q9UHY1", 0.7748929971814376], ["Q9UL15", 0.7748929971814376], ["Q9UNM6", 0.7748929971814376], ["O14908", 0.7077105899433705], ["O94888", 0.7077105899433705], ["P00390", 0.7077105899433705], ["P00491", 0.7077105899433705], ["P07195", 0.7077105899433705], ["P07305", 0.7077105899433705], ["P07737", 0.7077105899433705], ["P08708", 0.7077105899433705], ["P10398", 0.7077105899433705], ["P11766", 0.7077105899433705], ["P13051", 0.7077105899433705], ["P13639", 0.7077105899433705], ["P14635", 0.7077105899433705], ["P20839", 0.7077105899433705], ["P26639", 0.7077105899433705], ["P28340", 0.7077105899433705], ["P31323", 0.7077105899433705], ["P33991", 0.7077105899433705], ["P34896", 0.7077105899433705], ["P40227", 0.7077105899433705], ["P40616", 0.7077105899433705], ["P48047", 0.7077105899433705], ["P49247", 0.7077105899433705], ["P49642", 0.7077105899433705], ["P49721", 0.7077105899433705], ["P49902", 0.7077105899433705], ["P52597", 0.7077105899433705], ["P55010", 0.7077105899433705], ["P55039", 0.7077105899433705], ["P55263", 0.7077105899433705], ["P60660", 0.7077105899433705], ["P61201", 0.7077105899433705], ["P68036", 0.7077105899433705], ["Q06210", 0.7077105899433705], ["Q08209", 0.7077105899433705], ["Q0VDF9", 0.7077105899433705], ["Q13155", 0.7077105899433705], ["Q13347", 0.7077105899433705], ["Q13503", 0.7077105899433705], ["Q13572", 0.7077105899433705], ["Q14651", 0.7077105899433705], ["Q15014", 0.7077105899433705], ["Q15102", 0.7077105899433705], ["Q15813", 0.7077105899433705], ["Q16718", 0.7077105899433705], ["Q3ZCW2", 0.7077105899433705], ["Q5F1R6", 0.7077105899433705], ["Q7L2J0", 0.7077105899433705], ["Q7L5N1", 0.7077105899433705], ["Q7Z2Z2", 0.7077105899433705], ["Q8NB14", 0.7077105899433705], ["Q8NCA5", 0.7077105899433705], ["Q92905", 0.7077105899433705], ["Q969U7", 0.7077105899433705], ["Q96EK6", 0.7077105899433705], ["Q96GD0", 0.7077105899433705], ["Q96J02", 0.7077105899433705], ["Q96KP4", 0.7077105899433705], ["Q96S66", 0.7077105899433705], ["Q99615", 0.7077105899433705], ["Q99735", 0.7077105899433705], ["Q99832", 0.7077105899433705], ["Q9BPU6", 0.7077105899433705], ["Q9BUR4", 0.7077105899433705], ["Q9BY44", 0.7077105899433705], ["Q9H4L7", 0.7077105899433705], ["Q9HAV4", 0.7077105899433705], ["Q9NT62", 0.7077105899433705], ["Q9NUL3", 0.7077105899433705], ["Q9NVE7", 0.7077105899433705], ["Q9UQB8", 0.7077105899433705], ["Q9Y263", 0.7077105899433705], ["Q9Y3P9", 0.7077105899433705], ["O00203", 0.6408786461138315], ["O14745", 0.6408786461138315], ["O15027", 0.6408786461138315], ["O15145", 0.6408786461138315], ["O75534", 0.6408786461138315], ["O75818", 0.6408786461138315], ["P00558", 0.6408786461138315], ["P10768", 0.6408786461138315], ["P13693", 0.6408786461138315], ["P14550", 0.6408786461138315], ["P17980", 0.6408786461138315], ["P22234", 0.6408786461138315], ["P27635", 0.6408786461138315], ["P31689", 0.6408786461138315], ["P37802", 0.6408786461138315], ["P42771", 0.6408786461138315], ["P46781", 0.6408786461138315], ["P48507", 0.6408786461138315], ["P49005", 0.6408786461138315], ["P49321", 0.6408786461138315], ["P50579", 0.6408786461138315], ["P51003", 0.6408786461138315], ["P52701", 0.6408786461138315], ["P60981", 0.6408786461138315], ["P60983", 0.6408786461138315], ["P61160", 0.6408786461138315], ["P61353", 0.6408786461138315], ["P62191", 0.6408786461138315], ["P62269", 0.6408786461138315], ["P62273", 0.6408786461138315], ["P62701", 0.6408786461138315], ["P62750", 0.6408786461138315], ["P62820", 0.6408786461138315], ["Q06787", 0.6408786461138315], ["Q09028", 0.6408786461138315], ["Q12955", 0.6408786461138315], ["Q13148", 0.6408786461138315], ["Q13283", 0.6408786461138315], ["Q14240", 0.6408786461138315], ["Q14241", 0.6408786461138315], ["Q14258", 0.6408786461138315], ["Q14694", 0.6408786461138315], ["Q15126", 0.6408786461138315], ["Q15185", 0.6408786461138315], ["Q15257", 0.6408786461138315], ["Q15369", 0.6408786461138315], ["Q5TC12", 0.6408786461138315], ["Q5XKP0", 0.6408786461138315], ["Q6FI81", 0.6408786461138315], ["Q7L2H7", 0.6408786461138315], ["Q7Z4W1", 0.6408786461138315], ["Q86UV5", 0.6408786461138315], ["Q86Y56", 0.6408786461138315], ["Q8IUR0", 0.6408786461138315], ["Q8IVW6", 0.6408786461138315], ["Q8IWS0", 0.6408786461138315], ["Q8IXH7", 0.6408786461138315], ["Q8IYS1", 0.6408786461138315], ["Q8N7H5", 0.6408786461138315], ["Q8TD30", 0.6408786461138315], ["Q8WWM7", 0.6408786461138315], ["Q92547", 0.6408786461138315], ["Q92551", 0.6408786461138315], ["Q96AE4", 0.6408786461138315], ["Q96G03", 0.6408786461138315], ["Q96JJ3", 0.6408786461138315], ["Q96NB2", 0.6408786461138315], ["Q96P11", 0.6408786461138315], ["Q99436", 0.6408786461138315], ["Q9BU23", 0.6408786461138315], ["Q9H269", 0.6408786461138315], ["Q9NR09", 0.6408786461138315], ["Q9NRR5", 0.6408786461138315], ["Q9NZC9", 0.6408786461138315], ["Q9UI12", 0.6408786461138315], ["Q9UII4", 0.6408786461138315], ["Q9UNE7", 0.6408786461138315], ["Q9UQ80", 0.6408786461138315], ["Q9Y217", 0.6408786461138315], ["Q9Y285", 0.6408786461138315], ["Q9Y295", 0.6408786461138315], ["Q9Y371", 0.6408786461138315], ["Q9Y5Y2", 0.6408786461138315], ["O00139", 0.5743981192426235], ["O43765", 0.5743981192426235], ["O60502", 0.5743981192426235], ["O76094", 0.5743981192426235], ["O94855", 0.5743981192426235], ["P00966", 0.5743981192426235], ["P04818", 0.5743981192426235], ["P06132", 0.5743981192426235], ["P08238", 0.5743981192426235], ["P09104", 0.5743981192426235], ["P11216", 0.5743981192426235], ["P11413", 0.5743981192426235], ["P11586", 0.5743981192426235], ["P13010", 0.5743981192426235], ["P21359", 0.5743981192426235], ["P22314", 0.5743981192426235], ["P23381", 0.5743981192426235], ["P25685", 0.5743981192426235], ["P26196", 0.5743981192426235], ["P29966", 0.5743981192426235], ["P30566", 0.5743981192426235], ["P30626", 0.5743981192426235], ["P42126", 0.5743981192426235], ["P46063", 0.5743981192426235], ["P46777", 0.5743981192426235], ["P50991", 0.5743981192426235], ["P53618", 0.5743981192426235], ["P54136", 0.5743981192426235], ["P60891", 0.5743981192426235], ["P61247", 0.5743981192426235], ["P61923", 0.5743981192426235], ["P62263", 0.5743981192426235], ["P62280", 0.5743981192426235], ["P62851", 0.5743981192426235], ["P63000", 0.5743981192426235], ["Q02878", 0.5743981192426235], ["Q13098", 0.5743981192426235], ["Q13200", 0.5743981192426235], ["Q13363", 0.5743981192426235], ["Q13547", 0.5743981192426235], ["Q14195", 0.5743981192426235], ["Q14247", 0.5743981192426235], ["Q15008", 0.5743981192426235], ["Q15477", 0.5743981192426235], ["Q15631", 0.5743981192426235], ["Q16513", 0.5743981192426235], ["Q16881", 0.5743981192426235], ["Q2TAA5", 0.5743981192426235], ["Q6P2E9", 0.5743981192426235], ["Q6PIY7", 0.5743981192426235], ["Q7Z4Q2", 0.5743981192426235], ["Q7Z5K2", 0.5743981192426235], ["Q8IXT5", 0.5743981192426235], ["Q8N8S7", 0.5743981192426235], ["Q8NEM2", 0.5743981192426235], ["Q8TEQ6", 0.5743981192426235], ["Q8WUM4", 0.5743981192426235], ["Q8WXX5", 0.5743981192426235], ["Q8WY36", 0.5743981192426235], ["Q92598", 0.5743981192426235], ["Q96AY3", 0.5743981192426235], ["Q96CW5", 0.5743981192426235], ["Q96NC0", 0.5743981192426235], ["Q99661", 0.5743981192426235], ["Q9BRA2", 0.5743981192426235], ["Q9BV44", 0.5743981192426235], ["Q9BXJ9", 0.5743981192426235], ["Q9GZT3", 0.5743981192426235], ["Q9H2J4", 0.5743981192426235], ["Q9H7E9", 0.5743981192426235], ["Q9NSD9", 0.5743981192426235], ["Q9NUQ6", 0.5743981192426235], ["Q9NZ32", 0.5743981192426235], ["Q9UBB4", 0.5743981192426235], ["Q9UBB6", 0.5743981192426235], ["Q9UBT2", 0.5743981192426235], ["Q9UER7", 0.5743981192426235], ["Q9UET6", 0.5743981192426235], ["Q9UHI6", 0.5743981192426235], ["Q9Y237", 0.5743981192426235], ["Q9Y2V2", 0.5743981192426235], ["Q9Y4X5", 0.5743981192426235], ["Q9Y530", 0.5743981192426235], ["Q9Y5K6", 0.5743981192426235], ["O00303", 0.50826997316469], ["O00743", 0.50826997316469], ["O14976", 0.50826997316469], ["O15372", 0.50826997316469], ["O43242", 0.50826997316469], ["O43865", 0.50826997316469], ["O75340", 0.50826997316469], ["O75521", 0.50826997316469], ["O95295", 0.50826997316469], ["O95486", 0.50826997316469], ["O95793", 0.50826997316469], ["P08243", 0.50826997316469], ["P09960", 0.50826997316469], ["P14618", 0.50826997316469], ["P23588", 0.50826997316469], ["P26640", 0.50826997316469], ["P27348", 0.50826997316469], ["P27816", 0.50826997316469], ["P31930", 0.50826997316469], ["P32969", 0.50826997316469], ["P46776", 0.50826997316469], ["P48506", 0.50826997316469], ["P49821", 0.50826997316469], ["P52739", 0.50826997316469], ["P54105", 0.50826997316469], ["P54652", 0.50826997316469], ["P55209", 0.50826997316469], ["P61011", 0.50826997316469], ["P62241", 0.50826997316469], ["P62826", 0.50826997316469], ["Q01844", 0.50826997316469], ["Q02952", 0.50826997316469], ["Q13177", 0.50826997316469], ["Q13492", 0.50826997316469], ["Q14197", 0.50826997316469], ["Q14558", 0.50826997316469], ["Q15054", 0.50826997316469], ["Q16643", 0.50826997316469], ["Q3MHD2", 0.50826997316469], ["Q5H9R7", 0.50826997316469], ["Q6L8Q7", 0.50826997316469], ["Q8IV08", 0.50826997316469], ["Q8N1G2", 0.50826997316469], ["Q8WW59", 0.50826997316469], ["Q92820", 0.50826997316469], ["Q92974", 0.50826997316469], ["Q96F86", 0.50826997316469], ["Q96J01", 0.50826997316469], ["Q96P16", 0.50826997316469], ["Q96S44", 0.50826997316469], ["Q99829", 0.50826997316469], ["Q9BT73", 0.50826997316469], ["Q9BVI4", 0.50826997316469], ["Q9BWS9", 0.50826997316469], ["Q9BZH6", 0.50826997316469], ["Q9GZZ1", 0.50826997316469], ["Q9H2G2", 0.50826997316469], ["Q9NRN7", 0.50826997316469], ["Q9NVI1", 0.50826997316469], ["Q9NX24", 0.50826997316469], ["Q9P000", 0.50826997316469], ["Q9P2T1", 0.50826997316469], ["Q9UGN5", 0.50826997316469], ["Q9UHV9", 0.50826997316469], ["Q9UNS1", 0.50826997316469], ["Q9Y314", 0.50826997316469], ["Q9Y4B6", 0.50826997316469], ["Q9Y5X3", 0.50826997316469], ["A0AVT1", 0.4424951821953541], ["O00178", 0.4424951821953541], ["O00487", 0.4424951821953541], ["O14617", 0.4424951821953541], ["O43148", 0.4424951821953541], ["O43396", 0.4424951821953541], ["O43674", 0.4424951821953541], ["O43709", 0.4424951821953541], ["O60610", 0.4424951821953541], ["O75940", 0.4424951821953541], ["O95816", 0.4424951821953541], ["P06737", 0.4424951821953541], ["P06753", 0.4424951821953541], ["P09110", 0.4424951821953541], ["P11908", 0.4424951821953541], ["P15311", 0.4424951821953541], ["P18124", 0.4424951821953541], ["P18887", 0.4424951821953541], ["P20618", 0.4424951821953541], ["P23528", 0.4424951821953541], ["P30050", 0.4424951821953541], ["P41567", 0.4424951821953541], ["P48444", 0.4424951821953541], ["P48739", 0.4424951821953541], ["P49589", 0.4424951821953541], ["P53990", 0.4424951821953541], ["P56192", 0.4424951821953541], ["P56377", 0.4424951821953541], ["P83881", 0.4424951821953541], ["Q00534", 0.4424951821953541], ["Q01804", 0.4424951821953541], ["Q01813", 0.4424951821953541], ["Q08257", 0.4424951821953541], ["Q12948", 0.4424951821953541], ["Q13310", 0.4424951821953541], ["Q13616", 0.4424951821953541], ["Q14974", 0.4424951821953541], ["Q15274", 0.4424951821953541], ["Q15386", 0.4424951821953541], ["Q15642", 0.4424951821953541], ["Q16537", 0.4424951821953541], ["Q16543", 0.4424951821953541], ["Q5JSZ5", 0.4424951821953541], ["Q6IQ49", 0.4424951821953541], ["Q6YP21", 0.4424951821953541], ["Q8IWZ3", 0.4424951821953541], ["Q8IYB3", 0.4424951821953541], ["Q8IYB5", 0.4424951821953541], ["Q8WUH2", 0.4424951821953541], ["Q8WWH5", 0.4424951821953541], ["Q92692", 0.4424951821953541], ["Q96CU9", 0.4424951821953541], ["Q96DV4", 0.4424951821953541], ["Q96L58", 0.4424951821953541], ["Q99471", 0.4424951821953541], ["Q9GZS3", 0.4424951821953541], ["Q9H8Y8", 0.4424951821953541], ["Q9NQW6", 0.4424951821953541], ["Q9NWX6", 0.4424951821953541], ["Q9NZB2", 0.4424951821953541], ["Q9UBQ0", 0.4424951821953541], ["Q9UHD8", 0.4424951821953541], ["Q9ULX3", 0.4424951821953541], ["Q9UN86", 0.4424951821953541], ["Q9Y262", 0.4424951821953541], ["Q9Y6A4", 0.4424951821953541], ["O00231", 0.37707473133088987], ["O00425", 0.37707473133088987], ["O00471", 0.37707473133088987], ["O00625", 0.37707473133088987], ["O14646", 0.37707473133088987], ["O14802", 0.37707473133088987], ["O43432", 0.37707473133088987], ["O60830", 0.37707473133088987], ["O75947", 0.37707473133088987], ["O94927", 0.37707473133088987], ["O95372", 0.37707473133088987], ["P09874", 0.37707473133088987], ["P11274", 0.37707473133088987], ["P14868", 0.37707473133088987], ["P16383", 0.37707473133088987], ["P18074", 0.37707473133088987], ["P18858", 0.37707473133088987], ["P26038", 0.37707473133088987], ["P29144", 0.37707473133088987], ["P31937", 0.37707473133088987], ["P36405", 0.37707473133088987], ["P46060", 0.37707473133088987], ["P46199", 0.37707473133088987], ["P49588", 0.37707473133088987], ["P49755", 0.37707473133088987], ["P50750", 0.37707473133088987], ["P51114", 0.37707473133088987], ["P51553", 0.37707473133088987], ["P53041", 0.37707473133088987], ["P53396", 0.37707473133088987], ["P53582", 0.37707473133088987], ["P60228", 0.37707473133088987], ["P61020", 0.37707473133088987], ["P61163", 0.37707473133088987], ["P61981", 0.37707473133088987], ["P62829", 0.37707473133088987], ["P62906", 0.37707473133088987], ["P63096", 0.37707473133088987], ["P78345", 0.37707473133088987], ["Q04726", 0.37707473133088987], ["Q07020", 0.37707473133088987], ["Q08752", 0.37707473133088987], ["Q13257", 0.37707473133088987], ["Q13404", 0.37707473133088987], ["Q14126", 0.37707473133088987], ["Q14444", 0.37707473133088987], ["Q6P6C2", 0.37707473133088987], ["Q7LBC6", 0.37707473133088987], ["Q7Z392", 0.37707473133088987], ["Q86YR5", 0.37707473133088987], ["Q8IYS2", 0.37707473133088987], ["Q8NEZ5", 0.37707473133088987], ["Q8TEX9", 0.37707473133088987], ["Q8WVV9", 0.37707473133088987], ["Q92544", 0.37707473133088987], ["Q96ER3", 0.37707473133088987], ["Q96P70", 0.37707473133088987], ["Q96S59", 0.37707473133088987], ["Q9BTT6", 0.37707473133088987], ["Q9BUJ2", 0.37707473133088987], ["Q9GZP4", 0.37707473133088987], ["Q9GZZ9", 0.37707473133088987], ["Q9H8H2", 0.37707473133088987], ["Q9NP64", 0.37707473133088987], ["Q9NPH2", 0.37707473133088987], ["Q9NRK6", 0.37707473133088987], ["Q9NRZ9", 0.37707473133088987], ["Q9NTX5", 0.37707473133088987], ["Q9UBD5", 0.37707473133088987], ["Q9UFC0", 0.37707473133088987], ["Q9UNP9", 0.37707473133088987], ["Q9UPY3", 0.37707473133088987], ["Q9Y223", 0.37707473133088987], ["Q9Y4B4", 0.37707473133088987], ["Q9Y5B9", 0.37707473133088987], ["O00410", 0.31200961645461656], ["O14936", 0.31200961645461656], ["O14965", 0.31200961645461656], ["O15143", 0.31200961645461656], ["O43819", 0.31200961645461656], ["O60231", 0.31200961645461656], ["O75381", 0.31200961645461656], ["O75489", 0.31200961645461656], ["O75792", 0.31200961645461656], ["O95352", 0.31200961645461656], ["O95757", 0.31200961645461656], ["P16152", 0.31200961645461656], ["P22061", 0.31200961645461656], ["P24666", 0.31200961645461656], ["P33316", 0.31200961645461656], ["P35606", 0.31200961645461656], ["P36507", 0.31200961645461656], ["P37108", 0.31200961645461656], ["P40925", 0.31200961645461656], ["P41252", 0.31200961645461656], ["P46939", 0.31200961645461656], ["P48163", 0.31200961645461656], ["P49366", 0.31200961645461656], ["P49736", 0.31200961645461656], ["P54920", 0.31200961645461656], ["P61221", 0.31200961645461656], ["P61313", 0.31200961645461656], ["Q01518", 0.31200961645461656], ["Q13618", 0.31200961645461656], ["Q14141", 0.31200961645461656], ["Q14166", 0.31200961645461656], ["Q15018", 0.31200961645461656], ["Q15286", 0.31200961645461656], ["Q15750", 0.31200961645461656], ["Q16531", 0.31200961645461656], ["Q5VTL8", 0.31200961645461656], ["Q5VTR2", 0.31200961645461656], ["Q6P4Q7", 0.31200961645461656], ["Q7L014", 0.31200961645461656], ["Q86X55", 0.31200961645461656], ["Q86XP3", 0.31200961645461656], ["Q8TCG1", 0.31200961645461656], ["Q969V3", 0.31200961645461656], ["Q96D71", 0.31200961645461656], ["Q96FX7", 0.31200961645461656], ["Q96T51", 0.31200961645461656], ["Q99460", 0.31200961645461656], ["Q9BRX8", 0.31200961645461656], ["Q9BXS5", 0.31200961645461656], ["Q9H0W9", 0.31200961645461656], ["Q9HAD4", 0.31200961645461656], ["Q9NQX3", 0.31200961645461656], ["Q9NV88", 0.31200961645461656], ["Q9NZN8", 0.31200961645461656], ["Q9UBB9", 0.31200961645461656], ["Q9UDY2", 0.31200961645461656], ["Q9UGV2", 0.31200961645461656], ["Q9UNH7", 0.31200961645461656], ["Q9Y2L1", 0.31200961645461656], ["Q9Y2W6", 0.31200961645461656], ["Q9Y2Z4", 0.31200961645461656], ["Q9Y3A5", 0.31200961645461656], ["O15111", 0.2473008445487121], ["O15126", 0.2473008445487121], ["O15344", 0.2473008445487121], ["O15382", 0.2473008445487121], ["O43264", 0.2473008445487121], ["O43505", 0.2473008445487121], ["O75150", 0.2473008445487121], ["O75475", 0.2473008445487121], ["O95163", 0.2473008445487121], ["O95373", 0.2473008445487121], ["P00403", 0.2473008445487121], ["P06744", 0.2473008445487121], ["P07900", 0.2473008445487121], ["P07947", 0.2473008445487121], ["P0DMV9", 0.2473008445487121], ["P10809", 0.2473008445487121], ["P11802", 0.2473008445487121], ["P15927", 0.2473008445487121], ["P17174", 0.2473008445487121], ["P20338", 0.2473008445487121], ["P22059", 0.2473008445487121], ["P23921", 0.2473008445487121], ["P25398", 0.2473008445487121], ["P30048", 0.2473008445487121], ["P31948", 0.2473008445487121], ["P32321", 0.2473008445487121], ["P33176", 0.2473008445487121], ["P33993", 0.2473008445487121], ["P35613", 0.2473008445487121], ["P36404", 0.2473008445487121], ["P36578", 0.2473008445487121], ["P38606", 0.2473008445487121], ["P46940", 0.2473008445487121], ["P48556", 0.2473008445487121], ["P49841", 0.2473008445487121], ["P51148", 0.2473008445487121], ["P51149", 0.2473008445487121], ["P54577", 0.2473008445487121], ["P60510", 0.2473008445487121], ["P60842", 0.2473008445487121], ["P62136", 0.2473008445487121], ["P62993", 0.2473008445487121], ["Q01581", 0.2473008445487121], ["Q04637", 0.2473008445487121], ["Q04917", 0.2473008445487121], ["Q08945", 0.2473008445487121], ["Q12893", 0.2473008445487121], ["Q13395", 0.2473008445487121], ["Q13485", 0.2473008445487121], ["Q13505", 0.2473008445487121], ["Q13557", 0.2473008445487121], ["Q13617", 0.2473008445487121], ["Q13895", 0.2473008445487121], ["Q14C86", 0.2473008445487121], ["Q15120", 0.2473008445487121], ["Q15363", 0.2473008445487121], ["Q4G0F5", 0.2473008445487121], ["Q53FT3", 0.2473008445487121], ["Q6IAN0", 0.2473008445487121], ["Q6UXN9", 0.2473008445487121], ["Q7Z4V5", 0.2473008445487121], ["Q7Z6Z7", 0.2473008445487121], ["Q8IW35", 0.2473008445487121], ["Q8TED1", 0.2473008445487121], ["Q92538", 0.2473008445487121], ["Q92614", 0.2473008445487121], ["Q92917", 0.2473008445487121], ["Q92930", 0.2473008445487121], ["Q92990", 0.2473008445487121], ["Q96BW9", 0.2473008445487121], ["Q96KC2", 0.2473008445487121], ["Q96SY0", 0.2473008445487121], ["Q99707", 0.2473008445487121], ["Q9BPW8", 0.2473008445487121], ["Q9BQ52", 0.2473008445487121], ["Q9BR61", 0.2473008445487121], ["Q9BRJ2", 0.2473008445487121], ["Q9BTE6", 0.2473008445487121], ["Q9BUB5", 0.2473008445487121], ["Q9BVG4", 0.2473008445487121], ["Q9NR31", 0.2473008445487121], ["Q9NRV9", 0.2473008445487121], ["Q9NXV2", 0.2473008445487121], ["Q9NYL9", 0.2473008445487121], ["Q9NYV4", 0.2473008445487121], ["Q9NZI8", 0.2473008445487121], ["Q9UBF2", 0.2473008445487121], ["Q9UFW8", 0.2473008445487121], ["Q9UG63", 0.2473008445487121], ["Q9UHD2", 0.2473008445487121], ["Q9UKA9", 0.2473008445487121], ["Q9UPT8", 0.2473008445487121], ["Q9Y3A6", 0.2473008445487121], ["Q9Y3C6", 0.2473008445487121], ["Q9Y490", 0.2473008445487121], ["Q9Y496", 0.2473008445487121], ["Q9Y606", 0.2473008445487121], ["Q9Y6G9", 0.2473008445487121], ["O00429", 0.18294943391196353], ["O00469", 0.18294943391196353], ["O14744", 0.18294943391196353], ["O43414", 0.18294943391196353], ["O60763", 0.18294943391196353], ["O60884", 0.18294943391196353], ["O75122", 0.18294943391196353], ["O75821", 0.18294943391196353], ["O94826", 0.18294943391196353], ["O95251", 0.18294943391196353], ["P10155", 0.18294943391196353], ["P11171", 0.18294943391196353], ["P17812", 0.18294943391196353], ["P19525", 0.18294943391196353], ["P22695", 0.18294943391196353], ["P23284", 0.18294943391196353], ["P26358", 0.18294943391196353], ["P33981", 0.18294943391196353], ["P35914", 0.18294943391196353], ["P43034", 0.18294943391196353], ["P45954", 0.18294943391196353], ["P51970", 0.18294943391196353], ["P52292", 0.18294943391196353], ["P53992", 0.18294943391196353], ["P54277", 0.18294943391196353], ["P55060", 0.18294943391196353], ["P61457", 0.18294943391196353], ["P62495", 0.18294943391196353], ["P62805", 0.18294943391196353], ["Q04760", 0.18294943391196353], ["Q13185", 0.18294943391196353], ["Q14318", 0.18294943391196353], ["Q15334", 0.18294943391196353], ["Q15345", 0.18294943391196353], ["Q53EP0", 0.18294943391196353], ["Q5GLZ8", 0.18294943391196353], ["Q5T280", 0.18294943391196353], ["Q5T653", 0.18294943391196353], ["Q6P4I2", 0.18294943391196353], ["Q6PI48", 0.18294943391196353], ["Q86U28", 0.18294943391196353], ["Q8IWV7", 0.18294943391196353], ["Q8IX18", 0.18294943391196353], ["Q8N9N2", 0.18294943391196353], ["Q8TAT6", 0.18294943391196353], ["Q8WVY7", 0.18294943391196353], ["Q8WXF1", 0.18294943391196353], ["Q8WYA6", 0.18294943391196353], ["Q92747", 0.18294943391196353], ["Q969H8", 0.18294943391196353], ["Q96EY7", 0.18294943391196353], ["Q96HQ2", 0.18294943391196353], ["Q96SK2", 0.18294943391196353], ["Q99536", 0.18294943391196353], ["Q99543", 0.18294943391196353], ["Q99570", 0.18294943391196353], ["Q9BR76", 0.18294943391196353], ["Q9H488", 0.18294943391196353], ["Q9HCE1", 0.18294943391196353], ["Q9NVA2", 0.18294943391196353], ["Q9NX14", 0.18294943391196353], ["Q9P015", 0.18294943391196353], ["Q9Y276", 0.18294943391196353], ["Q9Y281", 0.18294943391196353], ["Q9Y2L5", 0.18294943391196353], ["Q9Y3I1", 0.18294943391196353], ["Q9Y5Q8", 0.18294943391196353], ["Q9Y6Y8", 0.18294943391196353], ["O00629", 0.11895641438366357], ["O15294", 0.11895641438366357], ["O15371", 0.11895641438366357], ["O43808", 0.11895641438366357], ["O60566", 0.11895641438366357], ["O75153", 0.11895641438366357], ["O75390", 0.11895641438366357], ["O95881", 0.11895641438366357], ["P05166", 0.11895641438366357], ["P06733", 0.11895641438366357], ["P06865", 0.11895641438366357], ["P13807", 0.11895641438366357], ["P17612", 0.11895641438366357], ["P19447", 0.11895641438366357], ["P25440", 0.11895641438366357], ["P30044", 0.11895641438366357], ["P33992", 0.11895641438366357], ["P35241", 0.11895641438366357], ["P39023", 0.11895641438366357], ["P47897", 0.11895641438366357], ["P47985", 0.11895641438366357], ["P49189", 0.11895641438366357], ["P49257", 0.11895641438366357], ["P49914", 0.11895641438366357], ["P50570", 0.11895641438366357], ["P52758", 0.11895641438366357], ["P54098", 0.11895641438366357], ["P56545", 0.11895641438366357], ["P61019", 0.11895641438366357], ["P62857", 0.11895641438366357], ["P67870", 0.11895641438366357], ["P80404", 0.11895641438366357], ["P82663", 0.11895641438366357], ["Q01433", 0.11895641438366357], ["Q07666", 0.11895641438366357], ["Q07960", 0.11895641438366357], ["Q08380", 0.11895641438366357], ["Q12904", 0.11895641438366357], ["Q13131", 0.11895641438366357], ["Q13555", 0.11895641438366357], ["Q14203", 0.11895641438366357], ["Q15059", 0.11895641438366357], ["Q15436", 0.11895641438366357], ["Q5TA45", 0.11895641438366357], ["Q6DKI1", 0.11895641438366357], ["Q6IN85", 0.11895641438366357], ["Q6PJG6", 0.11895641438366357], ["Q6Y7W6", 0.11895641438366357], ["Q6YHU6", 0.11895641438366357], ["Q71RC2", 0.11895641438366357], ["Q8N163", 0.11895641438366357], ["Q8N6H7", 0.11895641438366357], ["Q8N983", 0.11895641438366357], ["Q8NB90", 0.11895641438366357], ["Q8TC07", 0.11895641438366357], ["Q92616", 0.11895641438366357], ["Q92688", 0.11895641438366357], ["Q93009", 0.11895641438366357], ["Q96CS3", 0.11895641438366357], ["Q96GM8", 0.11895641438366357], ["Q96I24", 0.11895641438366357], ["Q96JB5", 0.11895641438366357], ["Q96K76", 0.11895641438366357], ["Q96QK1", 0.11895641438366357], ["Q96RT1", 0.11895641438366357], ["Q9BVQ7", 0.11895641438366357], ["Q9BXS6", 0.11895641438366357], ["Q9BYT8", 0.11895641438366357], ["Q9H019", 0.11895641438366357], ["Q9H2U2", 0.11895641438366357], ["Q9H977", 0.11895641438366357], ["Q9HC36", 0.11895641438366357], ["Q9NP92", 0.11895641438366357], ["Q9NTJ4", 0.11895641438366357], ["Q9NVX0", 0.11895641438366357], ["Q9NVX2", 0.11895641438366357], ["Q9NYB0", 0.11895641438366357], ["Q9P2J5", 0.11895641438366357], ["Q9UNY4", 0.11895641438366357], ["Q9Y3D0", 0.11895641438366357], ["Q9Y4U1", 0.11895641438366357], ["Q9Y6X9", 0.11895641438366357], ["O00505", 0.05532282757387995], ["O15514", 0.05532282757387995], ["O43447", 0.05532282757387995], ["O43678", 0.05532282757387995], ["O75306", 0.05532282757387995], ["O75439", 0.05532282757387995], ["O75934", 0.05532282757387995], ["O95071", 0.05532282757387995], ["P07814", 0.05532282757387995], ["P09884", 0.05532282757387995], ["P13861", 0.05532282757387995], ["P16402", 0.05532282757387995], ["P19174", 0.05532282757387995], ["P19404", 0.05532282757387995], ["P21333", 0.05532282757387995], ["P21912", 0.05532282757387995], ["P25205", 0.05532282757387995], ["P27708", 0.05532282757387995], ["P29692", 0.05532282757387995], ["P30405", 0.05532282757387995], ["P32121", 0.05532282757387995], ["P35268", 0.05532282757387995], ["P38646", 0.05532282757387995], ["P40938", 0.05532282757387995], ["P49327", 0.05532282757387995], ["P50851", 0.05532282757387995], ["P51610", 0.05532282757387995], ["P54619", 0.05532282757387995], ["P61006", 0.05532282757387995], ["P61106", 0.05532282757387995], ["P61421", 0.05532282757387995], ["P62879", 0.05532282757387995], ["Q03426", 0.05532282757387995], ["Q13564", 0.05532282757387995], ["Q15024", 0.05532282757387995], ["Q32P28", 0.05532282757387995], ["Q3ZCQ8", 0.05532282757387995], ["Q4G0J3", 0.05532282757387995], ["Q5JRX3", 0.05532282757387995], ["Q5SWX8", 0.05532282757387995], ["Q658Y4", 0.05532282757387995], ["Q7L592", 0.05532282757387995], ["Q7Z460", 0.05532282757387995], ["Q7Z7E8", 0.05532282757387995], ["Q8ND04", 0.05532282757387995], ["Q8NDT2", 0.05532282757387995], ["Q8NEC7", 0.05532282757387995], ["Q8NFW8", 0.05532282757387995], ["Q8NHH9", 0.05532282757387995], ["Q8TBX8", 0.05532282757387995], ["Q8WUK0", 0.05532282757387995], ["Q8WX93", 0.05532282757387995], ["Q92973", 0.05532282757387995], ["Q93034", 0.05532282757387995], ["Q96EP5", 0.05532282757387995], ["Q96FV9", 0.05532282757387995], ["Q96N67", 0.05532282757387995], ["Q96TA1", 0.05532282757387995], ["Q9BTW9", 0.05532282757387995], ["Q9BUK6", 0.05532282757387995], ["Q9BZZ5", 0.05532282757387995], ["Q9H0R6", 0.05532282757387995], ["Q9NP72", 0.05532282757387995], ["Q9NS91", 0.05532282757387995], ["Q9NUB1", 0.05532282757387995], ["Q9NUP9", 0.05532282757387995], ["Q9UHN1", 0.05532282757387995], ["Q9Y266", 0.05532282757387995], ["Q9Y320", 0.05532282757387995], ["Q9Y3D3", 0.05532282757387995], ["Q9Y3D9", 0.05532282757387995], ["O00170", -0.007950272899659088], ["O00411", -0.007950272899659088], ["O14828", -0.007950272899659088], ["O15067", -0.007950272899659088], ["O43301", -0.007950272899659088], ["O43747", -0.007950272899659088], ["O43847", -0.007950272899659088], ["O60568", -0.007950272899659088], ["O75347", -0.007950272899659088], ["O75600", -0.007950272899659088], ["O75717", -0.007950272899659088], ["O75880", -0.007950272899659088], ["O75925", -0.007950272899659088], ["P07602", -0.007950272899659088], ["P09496", -0.007950272899659088], ["P11940", -0.007950272899659088], ["P18754", -0.007950272899659088], ["P20042", -0.007950272899659088], ["P20674", -0.007950272899659088], ["P21281", -0.007950272899659088], ["P22830", -0.007950272899659088], ["P26368", -0.007950272899659088], ["P30154", -0.007950272899659088], ["P35573", -0.007950272899659088], ["P35579", -0.007950272899659088], ["P42694", -0.007950272899659088], ["P46379", -0.007950272899659088], ["P49207", -0.007950272899659088], ["P51116", -0.007950272899659088], ["P52306", -0.007950272899659088], ["P53634", -0.007950272899659088], ["P55786", -0.007950272899659088], ["P58107", -0.007950272899659088], ["P61158", -0.007950272899659088], ["P61513", -0.007950272899659088], ["P62258", -0.007950272899659088], ["P62304", -0.007950272899659088], ["P82930", -0.007950272899659088], ["P82933", -0.007950272899659088], ["Q00341", -0.007950272899659088], ["Q05519", -0.007950272899659088], ["Q12768", -0.007950272899659088], ["Q12872", -0.007950272899659088], ["Q13084", -0.007950272899659088], ["Q13907", -0.007950272899659088], ["Q14019", -0.007950272899659088], ["Q14152", -0.007950272899659088], ["Q14566", -0.007950272899659088], ["Q14738", -0.007950272899659088], ["Q15042", -0.007950272899659088], ["Q15046", -0.007950272899659088], ["Q4VCS5", -0.007950272899659088], ["Q5T8P6", -0.007950272899659088], ["Q5VTB9", -0.007950272899659088], ["Q6RFH5", -0.007950272899659088], ["Q76FK4", -0.007950272899659088], ["Q86SX6", -0.007950272899659088], ["Q86VN1", -0.007950272899659088], ["Q86W56", -0.007950272899659088], ["Q86WX3", -0.007950272899659088], ["Q8IU81", -0.007950272899659088], ["Q8IWX8", -0.007950272899659088], ["Q8N684", -0.007950272899659088], ["Q92900", -0.007950272899659088], ["Q96AC1", -0.007950272899659088], ["Q96JI7", -0.007950272899659088], ["Q96T76", -0.007950272899659088], ["Q9BQ69", -0.007950272899659088], ["Q9BXB4", -0.007950272899659088], ["Q9BXP5", -0.007950272899659088], ["Q9BXW7", -0.007950272899659088], ["Q9H0G5", -0.007950272899659088], ["Q9H3P7", -0.007950272899659088], ["Q9HCK8", -0.007950272899659088], ["Q9NW08", -0.007950272899659088], ["Q9UBF8", -0.007950272899659088], ["Q9UGP4", -0.007950272899659088], ["Q9UJ70", -0.007950272899659088], ["Q9UKD2", -0.007950272899659088], ["Q9UKF6", -0.007950272899659088], ["Q9UKJ3", -0.007950272899659088], ["Q9UQN3", -0.007950272899659088], ["Q9Y5A9", -0.007950272899659088], ["A6NHR9", -0.07086182116781163], ["O14786", -0.07086182116781163], ["O14818", -0.07086182116781163], ["O15047", -0.07086182116781163], ["O15085", -0.07086182116781163], ["O15155", -0.07086182116781163], ["O15400", -0.07086182116781163], ["O15446", -0.07086182116781163], ["O43172", -0.07086182116781163], ["O43776", -0.07086182116781163], ["O60271", -0.07086182116781163], ["O75165", -0.07086182116781163], ["O94979", -0.07086182116781163], ["O95202", -0.07086182116781163], ["O95239", -0.07086182116781163], ["O95347", -0.07086182116781163], ["P04181", -0.07086182116781163], ["P07954", -0.07086182116781163], ["P12956", -0.07086182116781163], ["P16278", -0.07086182116781163], ["P16403", -0.07086182116781163], ["P20336", -0.07086182116781163], ["P29401", -0.07086182116781163], ["P30084", -0.07086182116781163], ["P31949", -0.07086182116781163], ["P33121", -0.07086182116781163], ["P36551", -0.07086182116781163], ["P40429", -0.07086182116781163], ["P40818", -0.07086182116781163], ["P40939", -0.07086182116781163], ["P48634", -0.07086182116781163], ["P49711", -0.07086182116781163], ["P54802", -0.07086182116781163], ["P55196", -0.07086182116781163], ["P60953", -0.07086182116781163], ["P61978", -0.07086182116781163], ["P62487", -0.07086182116781163], ["P82675", -0.07086182116781163], ["Q02218", -0.07086182116781163], ["Q02543", -0.07086182116781163], ["Q12792", -0.07086182116781163], ["Q12907", -0.07086182116781163], ["Q13045", -0.07086182116781163], ["Q13228", -0.07086182116781163], ["Q13263", -0.07086182116781163], ["Q13308", -0.07086182116781163], ["Q13740", -0.07086182116781163], ["Q13867", -0.07086182116781163], ["Q14139", -0.07086182116781163], ["Q14204", -0.07086182116781163], ["Q14677", -0.07086182116781163], ["Q15019", -0.07086182116781163], ["Q15648", -0.07086182116781163], ["Q15785", -0.07086182116781163], ["Q15904", -0.07086182116781163], ["Q16795", -0.07086182116781163], ["Q5VV42", -0.07086182116781163], ["Q659A1", -0.07086182116781163], ["Q6P1N9", -0.07086182116781163], ["Q7Z406", -0.07086182116781163], ["Q86UE4", -0.07086182116781163], ["Q86W42", -0.07086182116781163], ["Q8IUF8", -0.07086182116781163], ["Q8IXI2", -0.07086182116781163], ["Q8NFF5", -0.07086182116781163], ["Q8NHQ9", -0.07086182116781163], ["Q8WUA4", -0.07086182116781163], ["Q92506", -0.07086182116781163], ["Q92769", -0.07086182116781163], ["Q96BP3", -0.07086182116781163], ["Q96C36", -0.07086182116781163], ["Q96EK5", -0.07086182116781163], ["Q96HY6", -0.07086182116781163], ["Q96SZ6", -0.07086182116781163], ["Q9BQ75", -0.07086182116781163], ["Q9BTD8", -0.07086182116781163], ["Q9BXI6", -0.07086182116781163], ["Q9BXP2", -0.07086182116781163], ["Q9BYD6", -0.07086182116781163], ["Q9H267", -0.07086182116781163], ["Q9HCN8", -0.07086182116781163], ["Q9HD33", -0.07086182116781163], ["Q9NXV6", -0.07086182116781163], ["Q9NZB8", -0.07086182116781163], ["Q9P2R3", -0.07086182116781163], ["Q9UIA9", -0.07086182116781163], ["Q9ULT8", -0.07086182116781163], ["Q9Y2Q9", -0.07086182116781163], ["Q9Y3B3", -0.07086182116781163], ["Q9Y678", -0.07086182116781163], ["O15144", -0.13341073885915933], ["O43707", -0.13341073885915933], ["O60762", -0.13341073885915933], ["O75127", -0.13341073885915933], ["O75414", -0.13341073885915933], ["O75448", -0.13341073885915933], ["O94776", -0.13341073885915933], ["O94804", -0.13341073885915933], ["O94966", -0.13341073885915933], ["P01111", -0.13341073885915933], ["P04083", -0.13341073885915933], ["P08574", -0.13341073885915933], ["P10515", -0.13341073885915933], ["P13674", -0.13341073885915933], ["P35080", -0.13341073885915933], ["P35232", -0.13341073885915933], ["P35611", -0.13341073885915933], ["P42166", -0.13341073885915933], ["P49458", -0.13341073885915933], ["P50454", -0.13341073885915933], ["P50747", -0.13341073885915933], ["P51809", -0.13341073885915933], ["P53004", -0.13341073885915933], ["P53621", -0.13341073885915933], ["P56182", -0.13341073885915933], ["P61225", -0.13341073885915933], ["P78347", -0.13341073885915933], ["Q05086", -0.13341073885915933], ["Q07820", -0.13341073885915933], ["Q12756", -0.13341073885915933], ["Q12933", -0.13341073885915933], ["Q14008", -0.13341073885915933], ["Q14671", -0.13341073885915933], ["Q15393", -0.13341073885915933], ["Q16851", -0.13341073885915933], ["Q4G176", -0.13341073885915933], ["Q5VT52", -0.13341073885915933], ["Q5VYK3", -0.13341073885915933], ["Q6P2P2", -0.13341073885915933], ["Q7KZF4", -0.13341073885915933], ["Q7L2E3", -0.13341073885915933], ["Q7Z4H8", -0.13341073885915933], ["Q8NFH3", -0.13341073885915933], ["Q92499", -0.13341073885915933], ["Q92890", -0.13341073885915933], ["Q96F07", -0.13341073885915933], ["Q96I99", -0.13341073885915933], ["Q96S52", -0.13341073885915933], ["Q99714", -0.13341073885915933], ["Q9BVK6", -0.13341073885915933], ["Q9BW91", -0.13341073885915933], ["Q9BY42", -0.13341073885915933], ["Q9H223", -0.13341073885915933], ["Q9H9Q2", -0.13341073885915933], ["Q9HBH5", -0.13341073885915933], ["Q9HCC0", -0.13341073885915933], ["Q9NQ29", -0.13341073885915933], ["Q9NQ48", -0.13341073885915933], ["Q9NQG5", -0.13341073885915933], ["Q9NTJ3", -0.13341073885915933], ["Q9NV70", -0.13341073885915933], ["Q9NVJ2", -0.13341073885915933], ["Q9NYK5", -0.13341073885915933], ["Q9NZJ0", -0.13341073885915933], ["Q9UBW8", -0.13341073885915933], ["Q9UJX4", -0.13341073885915933], ["Q9UNW1", -0.13341073885915933], ["Q9UPN6", -0.13341073885915933], ["Q9Y277", -0.13341073885915933], ["Q9Y399", -0.13341073885915933], ["Q9Y450", -0.13341073885915933], ["Q9Y4W6", -0.13341073885915933], ["Q9Y5L0", -0.13341073885915933], ["Q9Y673", -0.13341073885915933], ["A4D1P6", -0.19559593484172347], ["O00571", -0.19559593484172347], ["O14967", -0.19559593484172347], ["O43395", -0.19559593484172347], ["O43592", -0.19559593484172347], ["O43913", -0.19559593484172347], ["O75369", -0.19559593484172347], ["O75376", -0.19559593484172347], ["O95292", -0.19559593484172347], ["O95563", -0.19559593484172347], ["O95864", -0.19559593484172347], ["P04899", -0.19559593484172347], ["P09001", -0.19559593484172347], ["P09661", -0.19559593484172347], ["P11279", -0.19559593484172347], ["P11717", -0.19559593484172347], ["P12955", -0.19559593484172347], ["P14923", -0.19559593484172347], ["P24468", -0.19559593484172347], ["P43487", -0.19559593484172347], ["P46459", -0.19559593484172347], ["P48735", -0.19559593484172347], ["P49916", -0.19559593484172347], ["P50748", -0.19559593484172347], ["P51153", -0.19559593484172347], ["P52272", -0.19559593484172347], ["P52732", -0.19559593484172347], ["P53350", -0.19559593484172347], ["P53597", -0.19559593484172347], ["P54886", -0.19559593484172347], ["P55809", -0.19559593484172347], ["P62873", -0.19559593484172347], ["P78537", -0.19559593484172347], ["Q00610", -0.19559593484172347], ["Q08378", -0.19559593484172347], ["Q12923", -0.19559593484172347], ["Q13464", -0.19559593484172347], ["Q13642", -0.19559593484172347], ["Q14249", -0.19559593484172347], ["Q14679", -0.19559593484172347], ["Q14789", -0.19559593484172347], ["Q15021", -0.19559593484172347], ["Q15154", -0.19559593484172347], ["Q5T200", -0.19559593484172347], ["Q5T440", -0.19559593484172347], ["Q66K74", -0.19559593484172347], ["Q68CQ4", -0.19559593484172347], ["Q6DKK2", -0.19559593484172347], ["Q6PGP7", -0.19559593484172347], ["Q6VMQ6", -0.19559593484172347], ["Q7Z2W4", -0.19559593484172347], ["Q7Z3T8", -0.19559593484172347], ["Q7Z434", -0.19559593484172347], ["Q86U38", -0.19559593484172347], ["Q8N8N7", -0.19559593484172347], ["Q8N9N7", -0.19559593484172347], ["Q8NBN7", -0.19559593484172347], ["Q8TAF3", -0.19559593484172347], ["Q8TAG9", -0.19559593484172347], ["Q8WUA2", -0.19559593484172347], ["Q92667", -0.19559593484172347], ["Q969Y2", -0.19559593484172347], ["Q96AB3", -0.19559593484172347], ["Q96AX1", -0.19559593484172347], ["Q96HC4", -0.19559593484172347], ["Q9BRG1", -0.19559593484172347], ["Q9BV86", -0.19559593484172347], ["Q9BZJ0", -0.19559593484172347], ["Q9H0V9", -0.19559593484172347], ["Q9H2M9", -0.19559593484172347], ["Q9H3U1", -0.19559593484172347], ["Q9P265", -0.19559593484172347], ["Q9P2W9", -0.19559593484172347], ["Q9UI10", -0.19559593484172347], ["Q9UI26", -0.19559593484172347], ["Q9Y6C9", -0.19559593484172347], ["A1L0T0", -0.25741630495703344], ["O14980", -0.25741630495703344], ["O15397", -0.25741630495703344], ["O43815", -0.25741630495703344], ["O60749", -0.25741630495703344], ["O75396", -0.25741630495703344], ["O75592", -0.25741630495703344], ["O94874", -0.25741630495703344], ["O94905", -0.25741630495703344], ["O95319", -0.25741630495703344], ["P04439", -0.25741630495703344], ["P10586", -0.25741630495703344], ["P10619", -0.25741630495703344], ["P11177", -0.25741630495703344], ["P12235", -0.25741630495703344], ["P13804", -0.25741630495703344], ["P15924", -0.25741630495703344], ["P16930", -0.25741630495703344], ["P22570", -0.25741630495703344], ["P31040", -0.25741630495703344], ["P32322", -0.25741630495703344], ["P35659", -0.25741630495703344], ["P42785", -0.25741630495703344], ["P50213", -0.25741630495703344], ["P55884", -0.25741630495703344], ["P57678", -0.25741630495703344], ["P78527", -0.25741630495703344], ["Q00577", -0.25741630495703344], ["Q02809", -0.25741630495703344], ["Q05397", -0.25741630495703344], ["Q07065", -0.25741630495703344], ["Q0VDG4", -0.25741630495703344], ["Q10567", -0.25741630495703344], ["Q12905", -0.25741630495703344], ["Q14103", -0.25741630495703344], ["Q14674", -0.25741630495703344], ["Q14807", -0.25741630495703344], ["Q15291", -0.25741630495703344], ["Q15637", -0.25741630495703344], ["Q15758", -0.25741630495703344], ["Q29RF7", -0.25741630495703344], ["Q53GS7", -0.25741630495703344], ["Q6GMV3", -0.25741630495703344], ["Q6P587", -0.25741630495703344], ["Q86VP6", -0.25741630495703344], ["Q86XI2", -0.25741630495703344], ["Q86YS7", -0.25741630495703344], ["Q8IWA4", -0.25741630495703344], ["Q8NE86", -0.25741630495703344], ["Q8NF37", -0.25741630495703344], ["Q8NFC6", -0.25741630495703344], ["Q8TB36", -0.25741630495703344], ["Q8WVM0", -0.25741630495703344], ["Q92643", -0.25741630495703344], ["Q93008", -0.25741630495703344], ["Q96B26", -0.25741630495703344], ["Q96EB6", -0.25741630495703344], ["Q96GW9", -0.25741630495703344], ["Q96SU4", -0.25741630495703344], ["Q96T88", -0.25741630495703344], ["Q96TC7", -0.25741630495703344], ["Q99575", -0.25741630495703344], ["Q99747", -0.25741630495703344], ["Q9BRZ2", -0.25741630495703344], ["Q9H2U1", -0.25741630495703344], ["Q9H9J2", -0.25741630495703344], ["Q9HDC9", -0.25741630495703344], ["Q9NQC3", -0.25741630495703344], ["Q9NR12", -0.25741630495703344], ["Q9NXK8", -0.25741630495703344], ["Q9P0L0", -0.25741630495703344], ["Q9UHB6", -0.25741630495703344], ["Q9ULV4", -0.25741630495703344], ["Q9UNQ2", -0.25741630495703344], ["Q9UQ84", -0.25741630495703344], ["Q9Y3B7", -0.25741630495703344], ["Q9Y5S9", -0.25741630495703344], ["Q9Y6M1", -0.25741630495703344], ["O14974", -0.31887073174617964], ["O60216", -0.31887073174617964], ["O60841", -0.31887073174617964], ["O75494", -0.31887073174617964], ["O95182", -0.31887073174617964], ["O95453", -0.31887073174617964], ["O95905", -0.31887073174617964], ["P04844", -0.31887073174617964], ["P05026", -0.31887073174617964], ["P05091", -0.31887073174617964], ["P06400", -0.31887073174617964], ["P07384", -0.31887073174617964], ["P08195", -0.31887073174617964], ["P08754", -0.31887073174617964], ["P18206", -0.31887073174617964], ["P20339", -0.31887073174617964], ["P21283", -0.31887073174617964], ["P23193", -0.31887073174617964], ["P36542", -0.31887073174617964], ["P52298", -0.31887073174617964], ["P52789", -0.31887073174617964], ["P54646", -0.31887073174617964], ["P54727", -0.31887073174617964], ["P56537", -0.31887073174617964], ["P61586", -0.31887073174617964], ["P62380", -0.31887073174617964], ["P78344", -0.31887073174617964], ["P84095", -0.31887073174617964], ["Q00796", -0.31887073174617964], ["Q05655", -0.31887073174617964], ["Q10471", -0.31887073174617964], ["Q13601", -0.31887073174617964], ["Q13724", -0.31887073174617964], ["Q13868", -0.31887073174617964], ["Q14165", -0.31887073174617964], ["Q14554", -0.31887073174617964], ["Q14964", -0.31887073174617964], ["Q16836", -0.31887073174617964], ["Q16891", -0.31887073174617964], ["Q53H96", -0.31887073174617964], ["Q5JRA6", -0.31887073174617964], ["Q5RKV6", -0.31887073174617964], ["Q5T3I0", -0.31887073174617964], ["Q5T4S7", -0.31887073174617964], ["Q5TAX3", -0.31887073174617964], ["Q7Z3U7", -0.31887073174617964], ["Q86Y37", -0.31887073174617964], ["Q86YN1", -0.31887073174617964], ["Q8N3C0", -0.31887073174617964], ["Q8NBT2", -0.31887073174617964], ["Q8NCM8", -0.31887073174617964], ["Q8WVM8", -0.31887073174617964], ["Q8WWY3", -0.31887073174617964], ["Q92620", -0.31887073174617964], ["Q96AG4", -0.31887073174617964], ["Q96CW1", -0.31887073174617964], ["Q96EL3", -0.31887073174617964], ["Q96EY4", -0.31887073174617964], ["Q96KP1", -0.31887073174617964], ["Q96L92", -0.31887073174617964], ["Q96QC0", -0.31887073174617964], ["Q96RR1", -0.31887073174617964], ["Q96S55", -0.31887073174617964], ["Q99598", -0.31887073174617964], ["Q9BTU6", -0.31887073174617964], ["Q9BW92", -0.31887073174617964], ["Q9BX68", -0.31887073174617964], ["Q9H9B4", -0.31887073174617964], ["Q9HBK9", -0.31887073174617964], ["Q9NQP4", -0.31887073174617964], ["Q9NR33", -0.31887073174617964], ["Q9NRX2", -0.31887073174617964], ["Q9NUQ7", -0.31887073174617964], ["Q9NYF8", -0.31887073174617964], ["Q9P031", -0.31887073174617964], ["Q9UHX1", -0.31887073174617964], ["Q9UJ83", -0.31887073174617964], ["Q9UJC5", -0.31887073174617964], ["Q9UJW0", -0.31887073174617964], ["Q9UK45", -0.31887073174617964], ["Q9UM54", -0.31887073174617964], ["Q9UQR0", -0.31887073174617964], ["Q9Y221", -0.31887073174617964], ["Q9Y2J2", -0.31887073174617964], ["Q9Y3A2", -0.31887073174617964], ["Q9Y6A5", -0.31887073174617964], ["O14776", -0.3799580841675913], ["O15381", -0.3799580841675913], ["O43772", -0.3799580841675913], ["O60573", -0.3799580841675913], ["O75746", -0.3799580841675913], ["O94813", -0.3799580841675913], ["O95299", -0.3799580841675913], ["P19387", -0.3799580841675913], ["P21964", -0.3799580841675913], ["P27448", -0.3799580841675913], ["P30040", -0.3799580841675913], ["P35221", -0.3799580841675913], ["P35251", -0.3799580841675913], ["P35610", -0.3799580841675913], ["P36873", -0.3799580841675913], ["P42167", -0.3799580841675913], ["P50995", -0.3799580841675913], ["P51649", -0.3799580841675913], ["P55795", -0.3799580841675913], ["P61009", -0.3799580841675913], ["P61086", -0.3799580841675913], ["P63010", -0.3799580841675913], ["P82673", -0.3799580841675913], ["P83876", -0.3799580841675913], ["Q02252", -0.3799580841675913], ["Q05D32", -0.3799580841675913], ["Q07955", -0.3799580841675913], ["Q12899", -0.3799580841675913], ["Q12996", -0.3799580841675913], ["Q13573", -0.3799580841675913], ["Q13619", -0.3799580841675913], ["Q15005", -0.3799580841675913], ["Q27J81", -0.3799580841675913], ["Q68CP9", -0.3799580841675913], ["Q6DKJ4", -0.3799580841675913], ["Q6UB35", -0.3799580841675913], ["Q7L0Y3", -0.3799580841675913], ["Q8N3Z3", -0.3799580841675913], ["Q8N442", -0.3799580841675913], ["Q8NBJ5", -0.3799580841675913], ["Q8NBJ7", -0.3799580841675913], ["Q8NE71", -0.3799580841675913], ["Q8TEM1", -0.3799580841675913], ["Q8WWK9", -0.3799580841675913], ["Q8WXI9", -0.3799580841675913], ["Q8WZA0", -0.3799580841675913], ["Q92575", -0.3799580841675913], ["Q96DT7", -0.3799580841675913], ["Q96EE3", -0.3799580841675913], ["Q96HE7", -0.3799580841675913], ["Q96IX5", -0.3799580841675913], ["Q99459", -0.3799580841675913], ["Q99733", -0.3799580841675913], ["Q9BQ95", -0.3799580841675913], ["Q9BRT2", -0.3799580841675913], ["Q9BUR5", -0.3799580841675913], ["Q9BYD2", -0.3799580841675913], ["Q9GZR2", -0.3799580841675913], ["Q9H0F7", -0.3799580841675913], ["Q9H0H5", -0.3799580841675913], ["Q9H270", -0.3799580841675913], ["Q9H2W6", -0.3799580841675913], ["Q9HAU5", -0.3799580841675913], ["Q9HCM4", -0.3799580841675913], ["Q9NNW5", -0.3799580841675913], ["Q9NUJ1", -0.3799580841675913], ["Q9UBK9", -0.3799580841675913], ["Q9UBU8", -0.3799580841675913], ["Q9UGI8", -0.3799580841675913], ["Q9UH99", -0.3799580841675913], ["Q9UI43", -0.3799580841675913], ["Q9ULC3", -0.3799580841675913], ["Q9UMS4", -0.3799580841675913], ["Q9UPN3", -0.3799580841675913], ["Q9Y2Q3", -0.3799580841675913], ["Q9Y2R5", -0.3799580841675913], ["O00291", -0.44067721730618226], ["O14654", -0.44067721730618226], ["O43156", -0.44067721730618226], ["O43663", -0.44067721730618226], ["O43681", -0.44067721730618226], ["O43823", -0.44067721730618226], ["O60488", -0.44067721730618226], ["O75380", -0.44067721730618226], ["O75616", -0.44067721730618226], ["O95714", -0.44067721730618226], ["P00367", -0.44067721730618226], ["P04792", -0.44067721730618226], ["P07858", -0.44067721730618226], ["P09543", -0.44067721730618226], ["P12814", -0.44067721730618226], ["P14854", -0.44067721730618226], ["P17480", -0.44067721730618226], ["P26599", -0.44067721730618226], ["P27824", -0.44067721730618226], ["P38117", -0.44067721730618226], ["P39656", -0.44067721730618226], ["P45880", -0.44067721730618226], ["P49411", -0.44067721730618226], ["P51572", -0.44067721730618226], ["P51659", -0.44067721730618226], ["P53007", -0.44067721730618226], ["P55011", -0.44067721730618226], ["P61026", -0.44067721730618226], ["P63167", -0.44067721730618226], ["P78406", -0.44067721730618226], ["Q02487", -0.44067721730618226], ["Q02978", -0.44067721730618226], ["Q12789", -0.44067721730618226], ["Q14254", -0.44067721730618226], ["Q15020", -0.44067721730618226], ["Q3YEC7", -0.44067721730618226], ["Q53H12", -0.44067721730618226], ["Q5PSV4", -0.44067721730618226], ["Q6P087", -0.44067721730618226], ["Q6PD62", -0.44067721730618226], ["Q6W2J9", -0.44067721730618226], ["Q6WCQ1", -0.44067721730618226], ["Q86VI3", -0.44067721730618226], ["Q86Y82", -0.44067721730618226], ["Q8IVL6", -0.44067721730618226], ["Q8IXI1", -0.44067721730618226], ["Q8WXA9", -0.44067721730618226], ["Q92576", -0.44067721730618226], ["Q92665", -0.44067721730618226], ["Q92947", -0.44067721730618226], ["Q92979", -0.44067721730618226], ["Q96A33", -0.44067721730618226], ["Q96BQ5", -0.44067721730618226], ["Q96CP7", -0.44067721730618226], ["Q96DH6", -0.44067721730618226], ["Q96ME1", -0.44067721730618226], ["Q9BPX6", -0.44067721730618226], ["Q9BSH4", -0.44067721730618226], ["Q9BVS4", -0.44067721730618226], ["Q9BYC9", -0.44067721730618226], ["Q9BZE1", -0.44067721730618226], ["Q9H0A8", -0.44067721730618226], ["Q9H845", -0.44067721730618226], ["Q9H9L3", -0.44067721730618226], ["Q9HAV7", -0.44067721730618226], ["Q9HD45", -0.44067721730618226], ["Q9NVN8", -0.44067721730618226], ["Q9NVS2", -0.44067721730618226], ["Q9P0K7", -0.44067721730618226], ["Q9P0M6", -0.44067721730618226], ["Q9P2R7", -0.44067721730618226], ["Q9UGP8", -0.44067721730618226], ["Q9UHQ9", -0.44067721730618226], ["Q9UJZ1", -0.44067721730618226], ["Q9UM00", -0.44067721730618226], ["Q9Y679", -0.44067721730618226], ["Q9Y6M9", -0.44067721730618226], ["O00186", -0.5010269720735259], ["O00567", -0.5010269720735259], ["O15091", -0.5010269720735259], ["O43143", -0.5010269720735259], ["O60783", -0.5010269720735259], ["O94822", -0.5010269720735259], ["O95168", -0.5010269720735259], ["P06280", -0.5010269720735259], ["P16435", -0.5010269720735259], ["P19022", -0.5010269720735259], ["P21399", -0.5010269720735259], ["P23378", -0.5010269720735259], ["P24539", -0.5010269720735259], ["P26885", -0.5010269720735259], ["P28331", -0.5010269720735259], ["P34897", -0.5010269720735259], ["P35580", -0.5010269720735259], ["P45877", -0.5010269720735259], ["P49848", -0.5010269720735259], ["P53367", -0.5010269720735259], ["P55769", -0.5010269720735259], ["P56134", -0.5010269720735259], ["P61916", -0.5010269720735259], ["P62140", -0.5010269720735259], ["P78316", -0.5010269720735259], ["P78540", -0.5010269720735259], ["P82912", -0.5010269720735259], ["Q01780", -0.5010269720735259], ["Q04323", -0.5010269720735259], ["Q04446", -0.5010269720735259], ["Q08722", -0.5010269720735259], ["Q12888", -0.5010269720735259], ["Q13112", -0.5010269720735259], ["Q14315", -0.5010269720735259], ["Q14562", -0.5010269720735259], ["Q14839", -0.5010269720735259], ["Q15048", -0.5010269720735259], ["Q15738", -0.5010269720735259], ["Q16822", -0.5010269720735259], ["Q5JTV8", -0.5010269720735259], ["Q5JTZ9", -0.5010269720735259], ["Q6PCB5", -0.5010269720735259], ["Q6UXV4", -0.5010269720735259], ["Q7Z7K6", -0.5010269720735259], ["Q86UP2", -0.5010269720735259], ["Q86X10", -0.5010269720735259], ["Q8IY18", -0.5010269720735259], ["Q8NFH4", -0.5010269720735259], ["Q8WUY1", -0.5010269720735259], ["Q92615", -0.5010269720735259], ["Q969N2", -0.5010269720735259], ["Q9BUQ8", -0.5010269720735259], ["Q9H078", -0.5010269720735259], ["Q9H3K2", -0.5010269720735259], ["Q9H3N1", -0.5010269720735259], ["Q9H857", -0.5010269720735259], ["Q9HC21", -0.5010269720735259], ["Q9HCD5", -0.5010269720735259], ["Q9NPD3", -0.5010269720735259], ["Q9NRX1", -0.5010269720735259], ["Q9NVH1", -0.5010269720735259], ["Q9NVI7", -0.5010269720735259], ["Q9NVV4", -0.5010269720735259], ["Q9UJV9", -0.5010269720735259], ["Q9UJX3", -0.5010269720735259], ["Q9UKL0", -0.5010269720735259], ["Q9Y6V7", -0.5010269720735259], ["A5YKK6", -0.5610061748986982], ["O14787", -0.5610061748986982], ["O15269", -0.5610061748986982], ["O43402", -0.5610061748986982], ["O60220", -0.5610061748986982], ["O60244", -0.5610061748986982], ["O75116", -0.5610061748986982], ["O75976", -0.5610061748986982], ["P10321", -0.5610061748986982], ["P18031", -0.5610061748986982], ["P23368", -0.5610061748986982], ["P40926", -0.5610061748986982], ["P42695", -0.5610061748986982], ["P43304", -0.5610061748986982], ["P49748", -0.5610061748986982], ["P51398", -0.5610061748986982], ["P53985", -0.5610061748986982], ["P62699", -0.5610061748986982], ["Q01082", -0.5610061748986982], ["Q12849", -0.5610061748986982], ["Q12906", -0.5610061748986982], ["Q13057", -0.5610061748986982], ["Q13330", -0.5610061748986982], ["Q13428", -0.5610061748986982], ["Q13823", -0.5610061748986982], ["Q15050", -0.5610061748986982], ["Q15149", -0.5610061748986982], ["Q15418", -0.5610061748986982], ["Q3SXM5", -0.5610061748986982], ["Q4G0N4", -0.5610061748986982], ["Q4KMQ2", -0.5610061748986982], ["Q53HL2", -0.5610061748986982], ["Q5VT66", -0.5610061748986982], ["Q5VZL5", -0.5610061748986982], ["Q5W111", -0.5610061748986982], ["Q6NVY1", -0.5610061748986982], ["Q6P996", -0.5610061748986982], ["Q6YN16", -0.5610061748986982], ["Q7Z2W9", -0.5610061748986982], ["Q8NBS9", -0.5610061748986982], ["Q8WUW1", -0.5610061748986982], ["Q92604", -0.5610061748986982], ["Q96GM5", -0.5610061748986982], ["Q96QE5", -0.5610061748986982], ["Q96SI9", -0.5610061748986982], ["Q96TA2", -0.5610061748986982], ["Q9BSJ2", -0.5610061748986982], ["Q9BVJ6", -0.5610061748986982], ["Q9BYG3", -0.5610061748986982], ["Q9GZS1", -0.5610061748986982], ["Q9GZT8", -0.5610061748986982], ["Q9H2H9", -0.5610061748986982], ["Q9HCS7", -0.5610061748986982], ["Q9NQZ2", -0.5610061748986982], ["Q9NRF9", -0.5610061748986982], ["Q9NRG9", -0.5610061748986982], ["Q9NWT1", -0.5610061748986982], ["Q9NZJ7", -0.5610061748986982], ["Q9UBL3", -0.5610061748986982], ["Q9UIC8", -0.5610061748986982], ["Q9UKK9", -0.5610061748986982], ["Q9UKX7", -0.5610061748986982], ["Q9ULE6", -0.5610061748986982], ["Q9Y2H6", -0.5610061748986982], ["Q9Y2R4", -0.5610061748986982], ["Q9Y2U8", -0.5610061748986982], ["Q9Y305", -0.5610061748986982], ["Q9Y394", -0.5610061748986982], ["Q9Y4C2", -0.5610061748986982], ["Q9Y4R8", -0.5610061748986982], ["Q9Y5M8", -0.5610061748986982], ["O14880", -0.6206136374094026], ["O15228", -0.6206136374094026], ["O43159", -0.6206136374094026], ["O60341", -0.6206136374094026], ["O60725", -0.6206136374094026], ["O75367", -0.6206136374094026], ["O76031", -0.6206136374094026], ["O94901", -0.6206136374094026], ["O96019", -0.6206136374094026], ["P00387", -0.6206136374094026], ["P10606", -0.6206136374094026], ["P11233", -0.6206136374094026], ["P12236", -0.6206136374094026], ["P15586", -0.6206136374094026], ["P24752", -0.6206136374094026], ["P29372", -0.6206136374094026], ["P30876", -0.6206136374094026], ["P31943", -0.6206136374094026], ["P39687", -0.6206136374094026], ["P42285", -0.6206136374094026], ["P42345", -0.6206136374094026], ["P43307", -0.6206136374094026], ["P49419", -0.6206136374094026], ["P53701", -0.6206136374094026], ["P54709", -0.6206136374094026], ["P57772", -0.6206136374094026], ["P63104", -0.6206136374094026], ["Q00325", -0.6206136374094026], ["Q00765", -0.6206136374094026], ["Q01085", -0.6206136374094026], ["Q01968", -0.6206136374094026], ["Q08170", -0.6206136374094026], ["Q08554", -0.6206136374094026], ["Q09161", -0.6206136374094026], ["Q12797", -0.6206136374094026], ["Q14697", -0.6206136374094026], ["Q14997", -0.6206136374094026], ["Q15022", -0.6206136374094026], ["Q4J6C6", -0.6206136374094026], ["Q5JTH9", -0.6206136374094026], ["Q5T9A4", -0.6206136374094026], ["Q69YH5", -0.6206136374094026], ["Q6P1J9", -0.6206136374094026], ["Q7L576", -0.6206136374094026], ["Q7Z3K3", -0.6206136374094026], ["Q7Z5G4", -0.6206136374094026], ["Q8IYB8", -0.6206136374094026], ["Q8N5L8", -0.6206136374094026], ["Q8NHP6", -0.6206136374094026], ["Q92552", -0.6206136374094026], ["Q92841", -0.6206136374094026], ["Q92878", -0.6206136374094026], ["Q96BK5", -0.6206136374094026], ["Q96DB5", -0.6206136374094026], ["Q96L91", -0.6206136374094026], ["Q99728", -0.6206136374094026], ["Q99797", -0.6206136374094026], ["Q9BQP7", -0.6206136374094026], ["Q9BTV4", -0.6206136374094026], ["Q9BYD1", -0.6206136374094026], ["Q9BYI3", -0.6206136374094026], ["Q9H1I8", -0.6206136374094026], ["Q9H4I3", -0.6206136374094026], ["Q9H4L4", -0.6206136374094026], ["Q9H501", -0.6206136374094026], ["Q9HCU5", -0.6206136374094026], ["Q9NPJ3", -0.6206136374094026], ["Q9NTJ5", -0.6206136374094026], ["Q9NV06", -0.6206136374094026], ["Q9NY93", -0.6206136374094026], ["Q9UBX3", -0.6206136374094026], ["Q9UNK0", -0.6206136374094026], ["Q9UPU5", -0.6206136374094026], ["Q9Y3B2", -0.6206136374094026], ["Q9Y3B9", -0.6206136374094026], ["A0FGR8", -0.6798481561029839], ["O00443", -0.6798481561029839], ["O43491", -0.6798481561029839], ["O75431", -0.6798481561029839], ["O75955", -0.6798481561029839], ["O95067", -0.6798481561029839], ["O95140", -0.6798481561029839], ["O95478", -0.6798481561029839], ["P00505", -0.6798481561029839], ["P04632", -0.6798481561029839], ["P04843", -0.6798481561029839], ["P05141", -0.6798481561029839], ["P05771", -0.6798481561029839], ["P08240", -0.6798481561029839], ["P09601", -0.6798481561029839], ["P18077", -0.6798481561029839], ["P19367", -0.6798481561029839], ["P22392", -0.6798481561029839], ["P38919", -0.6798481561029839], ["P42765", -0.6798481561029839], ["P43243", -0.6798481561029839], ["P51608", -0.6798481561029839], ["P56282", -0.6798481561029839], ["P62312", -0.6798481561029839], ["P62318", -0.6798481561029839], ["P84103", -0.6798481561029839], ["Q06265", -0.6798481561029839], ["Q13111", -0.6798481561029839], ["Q14145", -0.6798481561029839], ["Q14498", -0.6798481561029839], ["Q15061", -0.6798481561029839], ["Q4VC31", -0.6798481561029839], ["Q53GS9", -0.6798481561029839], ["Q6P1M0", -0.6798481561029839], ["Q6UW68", -0.6798481561029839], ["Q7L5D6", -0.6798481561029839], ["Q86V48", -0.6798481561029839], ["Q8IXK0", -0.6798481561029839], ["Q8IY95", -0.6798481561029839], ["Q8IZL8", -0.6798481561029839], ["Q8NFH5", -0.6798481561029839], ["Q969Z0", -0.6798481561029839], ["Q96BR5", -0.6798481561029839], ["Q96M89", -0.6798481561029839], ["Q9BPX3", -0.6798481561029839], ["Q9H0S4", -0.6798481561029839], ["Q9H160", -0.6798481561029839], ["Q9H871", -0.6798481561029839], ["Q9NP81", -0.6798481561029839], ["Q9NVH0", -0.6798481561029839], ["Q9UJS0", -0.6798481561029839], ["Q9ULW0", -0.6798481561029839], ["Q9UMY1", -0.6798481561029839], ["Q9UPP1", -0.6798481561029839], ["Q9Y5J9", -0.6798481561029839], ["O00267", -0.7387085120069009], ["O00541", -0.7387085120069009], ["O14657", -0.7387085120069009], ["O14773", -0.7387085120069009], ["O43615", -0.7387085120069009], ["O60306", -0.7387085120069009], ["O60832", -0.7387085120069009], ["O60934", -0.7387085120069009], ["O75131", -0.7387085120069009], ["O75323", -0.7387085120069009], ["O75477", -0.7387085120069009], ["O94761", -0.7387085120069009], ["O95104", -0.7387085120069009], ["O95363", -0.7387085120069009], ["P07686", -0.7387085120069009], ["P08621", -0.7387085120069009], ["P10253", -0.7387085120069009], ["P11498", -0.7387085120069009], ["P14625", -0.7387085120069009], ["P18433", -0.7387085120069009], ["P42696", -0.7387085120069009], ["P43897", -0.7387085120069009], ["P45973", -0.7387085120069009], ["P46100", -0.7387085120069009], ["P49756", -0.7387085120069009], ["P51571", -0.7387085120069009], ["Q10713", -0.7387085120069009], ["Q13242", -0.7387085120069009], ["Q13620", -0.7387085120069009], ["Q14344", -0.7387085120069009], ["Q14667", -0.7387085120069009], ["Q15047", -0.7387085120069009], ["Q15067", -0.7387085120069009], ["Q15233", -0.7387085120069009], ["Q15397", -0.7387085120069009], ["Q15398", -0.7387085120069009], ["Q16539", -0.7387085120069009], ["Q1ED39", -0.7387085120069009], ["Q53GQ0", -0.7387085120069009], ["Q5JVF3", -0.7387085120069009], ["Q6P3X3", -0.7387085120069009], ["Q6P4A7", -0.7387085120069009], ["Q7Z6I8", -0.7387085120069009], ["Q86SF2", -0.7387085120069009], ["Q8IXM2", -0.7387085120069009], ["Q8N2K0", -0.7387085120069009], ["Q8N8R3", -0.7387085120069009], ["Q8NAV1", -0.7387085120069009], ["Q8NBU5", -0.7387085120069009], ["Q8TDW0", -0.7387085120069009], ["Q96RP9", -0.7387085120069009], ["Q99442", -0.7387085120069009], ["Q9BVP2", -0.7387085120069009], ["Q9H0D6", -0.7387085120069009], ["Q9NQH7", -0.7387085120069009], ["Q9NSE4", -0.7387085120069009], ["Q9Y2P8", -0.7387085120069009], ["Q9Y2X0", -0.7387085120069009], ["Q9Y333", -0.7387085120069009], ["Q9Y512", -0.7387085120069009], ["A4D1E9", -0.7971934703282234], ["O00116", -0.7971934703282234], ["O00264", -0.7971934703282234], ["O43795", -0.7971934703282234], ["O95155", -0.7971934703282234], ["P09497", -0.7971934703282234], ["P16949", -0.7971934703282234], ["P18583", -0.7971934703282234], ["P20073", -0.7971934703282234], ["P22033", -0.7971934703282234], ["P30038", -0.7971934703282234], ["P30101", -0.7971934703282234], ["P35222", -0.7971934703282234], ["P42704", -0.7971934703282234], ["P50402", -0.7971934703282234], ["P52948", -0.7971934703282234], ["P57740", -0.7971934703282234], ["P61964", -0.7971934703282234], ["Q12874", -0.7971934703282234], ["Q13813", -0.7971934703282234], ["Q13838", -0.7971934703282234], ["Q14157", -0.7971934703282234], ["Q14966", -0.7971934703282234], ["Q14978", -0.7971934703282234], ["Q15031", -0.7971934703282234], ["Q15717", -0.7971934703282234], ["Q16134", -0.7971934703282234], ["Q5SNT2", -0.7971934703282234], ["Q6NUK1", -0.7971934703282234], ["Q6P1L8", -0.7971934703282234], ["Q6ZRS2", -0.7971934703282234], ["Q709C8", -0.7971934703282234], ["Q8IUH3", -0.7971934703282234], ["Q8IVS2", -0.7971934703282234], ["Q8N653", -0.7971934703282234], ["Q8TAQ2", -0.7971934703282234], ["Q8TCS8", -0.7971934703282234], ["Q8WVX9", -0.7971934703282234], ["Q92674", -0.7971934703282234], ["Q96DI7", -0.7971934703282234], ["Q96HS1", -0.7971934703282234], ["Q99729", -0.7971934703282234], ["Q9BZE4", -0.7971934703282234], ["Q9H2P0", -0.7971934703282234], ["Q9H7B2", -0.7971934703282234], ["Q9NQT5", -0.7971934703282234], ["Q9NSV4", -0.7971934703282234], ["Q9NYU2", -0.7971934703282234], ["Q9P2D1", -0.7971934703282234], ["Q9UHB7", -0.7971934703282234], ["Q9UQE7", -0.7971934703282234], ["Q9Y2A7", -0.7971934703282234], ["O14979", -0.855301780091687], ["O15484", -0.855301780091687], ["O43169", -0.855301780091687], ["O43290", -0.855301780091687], ["O60264", -0.855301780091687], ["O75251", -0.855301780091687], ["O94832", -0.855301780091687], ["O95573", -0.855301780091687], ["O95782", -0.855301780091687], ["O95785", -0.855301780091687], ["O96008", -0.855301780091687], ["P02786", -0.855301780091687], ["P05556", -0.855301780091687], ["P08133", -0.855301780091687], ["P09622", -0.855301780091687], ["P16219", -0.855301780091687], ["P36957", -0.855301780091687], ["P54132", -0.855301780091687], ["P55199", -0.855301780091687], ["P67936", -0.855301780091687], ["Q05048", -0.855301780091687], ["Q12788", -0.855301780091687], ["Q12824", -0.855301780091687], ["Q12931", -0.855301780091687], ["Q13042", -0.855301780091687], ["Q13409", -0.855301780091687], ["Q13435", -0.855301780091687], ["Q13610", -0.855301780091687], ["Q14669", -0.855301780091687], ["Q14696", -0.855301780091687], ["Q15029", -0.855301780091687], ["Q3KQU3", -0.855301780091687], ["Q5J8M3", -0.855301780091687], ["Q5VWN6", -0.855301780091687], ["Q6UWP7", -0.855301780091687], ["Q86VM9", -0.855301780091687], ["Q86VX2", -0.855301780091687], ["Q86XL3", -0.855301780091687], ["Q86Y39", -0.855301780091687], ["Q8IX12", -0.855301780091687], ["Q8N5M1", -0.855301780091687], ["Q8TB61", -0.855301780091687], ["Q8TC12", -0.855301780091687], ["Q92696", -0.855301780091687], ["Q969X5", -0.855301780091687], ["Q96FZ7", -0.855301780091687], ["Q96RQ3", -0.855301780091687], ["Q99798", -0.855301780091687], ["Q9BS26", -0.855301780091687], ["Q9BSC4", -0.855301780091687], ["Q9BTY2", -0.855301780091687], ["Q9BVS5", -0.855301780091687], ["Q9H307", -0.855301780091687], ["Q9HB40", -0.855301780091687], ["Q9NRW3", -0.855301780091687], ["Q9NX20", -0.855301780091687], ["Q9P1Y5", -0.855301780091687], ["Q9UBU9", -0.855301780091687], ["Q9UDR5", -0.855301780091687], ["Q9UH62", -0.855301780091687], ["Q9ULI0", -0.855301780091687], ["Q9ULV3", -0.855301780091687], ["Q9Y2B0", -0.855301780091687], ["Q9Y3B4", -0.855301780091687], ["Q9Y4A5", -0.855301780091687], ["O00148", -0.9130321737658023], ["O43660", -0.9130321737658023], ["O43683", -0.9130321737658023], ["O60508", -0.9130321737658023], ["O60716", -0.9130321737658023], ["O76021", -0.9130321737658023], ["O94973", -0.9130321737658023], ["O95197", -0.9130321737658023], ["O96028", -0.9130321737658023], ["P11310", -0.9130321737658023], ["P12270", -0.9130321737658023], ["P14866", -0.9130321737658023], ["P19388", -0.9130321737658023], ["P20020", -0.9130321737658023], ["P22307", -0.9130321737658023], ["P26440", -0.9130321737658023], ["P29375", -0.9130321737658023], ["P30536", -0.9130321737658023], ["P46087", -0.9130321737658023], ["P49406", -0.9130321737658023], ["P49959", -0.9130321737658023], ["P51648", -0.9130321737658023], ["P55145", -0.9130321737658023], ["P57088", -0.9130321737658023], ["P60468", -0.9130321737658023], ["P60604", -0.9130321737658023], ["P82914", -0.9130321737658023], ["Q01469", -0.9130321737658023], ["Q10570", -0.9130321737658023], ["Q13085", -0.9130321737658023], ["Q13206", -0.9130321737658023], ["Q5HYI8", -0.9130321737658023], ["Q6P158", -0.9130321737658023], ["Q6PJT7", -0.9130321737658023], ["Q7Z5J4", -0.9130321737658023], ["Q86YH6", -0.9130321737658023], ["Q8IWI9", -0.9130321737658023], ["Q8N5N7", -0.9130321737658023], ["Q8NBX0", -0.9130321737658023], ["Q96I25", -0.9130321737658023], ["Q96PV6", -0.9130321737658023], ["Q96ST3", -0.9130321737658023], ["Q9BRP4", -0.9130321737658023], ["Q9BRR6", -0.9130321737658023], ["Q9BSJ8", -0.9130321737658023], ["Q9BTC0", -0.9130321737658023], ["Q9BV38", -0.9130321737658023], ["Q9BW27", -0.9130321737658023], ["Q9BWH2", -0.9130321737658023], ["Q9NPJ6", -0.9130321737658023], ["Q9ULG1", -0.9130321737658023], ["Q9ULU4", -0.9130321737658023], ["Q9Y4C8", -0.9130321737658023], ["Q9Y4Z0", -0.9130321737658023], ["Q9Y5J1", -0.9130321737658023], ["O14734", -0.9703846246802348], ["O15213", -0.9703846246802348], ["O43837", -0.9703846246802348], ["O75683", -0.9703846246802348], ["O75694", -0.9703846246802348], ["O95831", -0.9703846246802348], ["P08670", -0.9703846246802348], ["P09651", -0.9703846246802348], ["P12532", -0.9703846246802348], ["P13995", -0.9703846246802348], ["P14373", -0.9703846246802348], ["P17844", -0.9703846246802348], ["P20290", -0.9703846246802348], ["P20810", -0.9703846246802348], ["P24928", -0.9703846246802348], ["P25705", -0.9703846246802348], ["P31946", -0.9703846246802348], ["P46783", -0.9703846246802348], ["P49792", -0.9703846246802348], ["Q06330", -0.9703846246802348], ["Q09666", -0.9703846246802348], ["Q12830", -0.9703846246802348], ["Q13123", -0.9703846246802348], ["Q14683", -0.9703846246802348], ["Q5SSJ5", -0.9703846246802348], ["Q68DK7", -0.9703846246802348], ["Q6IAA8", -0.9703846246802348], ["Q6NSI4", -0.9703846246802348], ["Q86YP4", -0.9703846246802348], ["Q8IXB1", -0.9703846246802348], ["Q8IY37", -0.9703846246802348], ["Q92625", -0.9703846246802348], ["Q92879", -0.9703846246802348], ["Q92922", -0.9703846246802348], ["Q969G3", -0.9703846246802348], ["Q969Z3", -0.9703846246802348], ["Q96C01", -0.9703846246802348], ["Q96EL2", -0.9703846246802348], ["Q96GC9", -0.9703846246802348], ["Q96JM7", -0.9703846246802348], ["Q96KR1", -0.9703846246802348], ["Q96ME7", -0.9703846246802348], ["Q9BY77", -0.9703846246802348], ["Q9BYB4", -0.9703846246802348], ["Q9BZF1", -0.9703846246802348], ["Q9GZR7", -0.9703846246802348], ["Q9H6F5", -0.9703846246802348], ["Q9H6R4", -0.9703846246802348], ["Q9H8H0", -0.9703846246802348], ["Q9NQ55", -0.9703846246802348], ["Q9NTI5", -0.9703846246802348], ["Q9NVU7", -0.9703846246802348], ["Q9NX58", -0.9703846246802348], ["Q9NX63", -0.9703846246802348], ["Q9UEY8", -0.9703846246802348], ["Q9UG56", -0.9703846246802348], ["Q9UKV3", -0.9703846246802348], ["Q9UP83", -0.9703846246802348], ["Q9Y2R9", -0.9703846246802348], ["Q9Y4W2", -0.9703846246802348], ["L0R6Q1", -1.0273640713432115], ["O00159", -1.0273640713432115], ["O00763", -1.0273640713432115], ["O94906", -1.0273640713432115], ["O94925", -1.0273640713432115], ["O95232", -1.0273640713432115], ["P07099", -1.0273640713432115], ["P14314", -1.0273640713432115], ["P21127", -1.0273640713432115], ["P30519", -1.0273640713432115], ["P37268", -1.0273640713432115], ["P49790", -1.0273640713432115], ["P54819", -1.0273640713432115], ["P55265", -1.0273640713432115], ["P61604", -1.0273640713432115], ["Q12981", -1.0273640713432115], ["Q13162", -1.0273640713432115], ["Q13247", -1.0273640713432115], ["Q13427", -1.0273640713432115], ["Q13510", -1.0273640713432115], ["Q14684", -1.0273640713432115], ["Q16740", -1.0273640713432115], ["Q4LE39", -1.0273640713432115], ["Q6NUM9", -1.0273640713432115], ["Q6UX53", -1.0273640713432115], ["Q7KZ85", -1.0273640713432115], ["Q86U86", -1.0273640713432115], ["Q8N1F7", -1.0273640713432115], ["Q8TB37", -1.0273640713432115], ["Q8WUM0", -1.0273640713432115], ["Q92541", -1.0273640713432115], ["Q92797", -1.0273640713432115], ["Q96A26", -1.0273640713432115], ["Q96EY1", -1.0273640713432115], ["Q96PK6", -1.0273640713432115], ["Q99567", -1.0273640713432115], ["Q99614", -1.0273640713432115], ["Q9BTX1", -1.0273640713432115], ["Q9BVL2", -1.0273640713432115], ["Q9BWF3", -1.0273640713432115], ["Q9H0A0", -1.0273640713432115], ["Q9H1K1", -1.0273640713432115], ["Q9H9Y2", -1.0273640713432115], ["Q9NY12", -1.0273640713432115], ["Q9P2E9", -1.0273640713432115], ["Q9UFN0", -1.0273640713432115], ["Q9Y2S7", -1.0273640713432115], ["Q9Y624", -1.0273640713432115], ["O15042", -1.083976561221463], ["O75845", -1.083976561221463], ["O75879", -1.083976561221463], ["O75964", -1.083976561221463], ["O94887", -1.083976561221463], ["O95059", -1.083976561221463], ["P05165", -1.083976561221463], ["P09234", -1.083976561221463], ["P16615", -1.083976561221463], ["P21796", -1.083976561221463], ["P22087", -1.083976561221463], ["P23786", -1.083976561221463], ["P30825", -1.083976561221463], ["P35658", -1.083976561221463], ["P39019", -1.083976561221463], ["P42356", -1.083976561221463], ["P49815", -1.083976561221463], ["P55084", -1.083976561221463], ["P63173", -1.083976561221463], ["Q13322", -1.083976561221463], ["Q15075", -1.083976561221463], ["Q15125", -1.083976561221463], ["Q16181", -1.083976561221463], ["Q16850", -1.083976561221463], ["Q2TAY7", -1.083976561221463], ["Q66K14", -1.083976561221463], ["Q69YQ0", -1.083976561221463], ["Q6ZXV5", -1.083976561221463], ["Q8IX01", -1.083976561221463], ["Q8N5K1", -1.083976561221463], ["Q8N8A6", -1.083976561221463], ["Q8N9T8", -1.083976561221463], ["Q8NBQ5", -1.083976561221463], ["Q8NE01", -1.083976561221463], ["Q8NI36", -1.083976561221463], ["Q8TAA5", -1.083976561221463], ["Q96I59", -1.083976561221463], ["Q96KM6", -1.083976561221463], ["Q96P48", -1.083976561221463], ["Q96QE3", -1.083976561221463], ["Q99623", -1.083976561221463], ["Q99640", -1.083976561221463], ["Q99808", -1.083976561221463], ["Q99848", -1.083976561221463], ["Q9BQ39", -1.083976561221463], ["Q9BXF3", -1.083976561221463], ["Q9GZL7", -1.083976561221463], ["Q9H9Y6", -1.083976561221463], ["Q9NR30", -1.083976561221463], ["Q9NU22", -1.083976561221463], ["Q9NXF1", -1.083976561221463], ["Q9P035", -1.083976561221463], ["Q9UJX2", -1.083976561221463], ["Q9Y487", -1.083976561221463], ["Q9Y5A7", -1.083976561221463], ["O60506", -1.1402279861545381], ["O75319", -1.1402279861545381], ["O75400", -1.1402279861545381], ["O75533", -1.1402279861545381], ["O75643", -1.1402279861545381], ["O75844", -1.1402279861545381], ["O94830", -1.1402279861545381], ["O94915", -1.1402279861545381], ["P32929", -1.1402279861545381], ["P33240", -1.1402279861545381], ["P50897", -1.1402279861545381], ["Q02040", -1.1402279861545381], ["Q03252", -1.1402279861545381], ["Q13423", -1.1402279861545381], ["Q6NUQ4", -1.1402279861545381], ["Q70HW3", -1.1402279861545381], ["Q75QN2", -1.1402279861545381], ["Q7Z7H8", -1.1402279861545381], ["Q86UL3", -1.1402279861545381], ["Q8IZH2", -1.1402279861545381], ["Q8N3X1", -1.1402279861545381], ["Q8N5W9", -1.1402279861545381], ["Q8TDN6", -1.1402279861545381], ["Q8WWQ0", -1.1402279861545381], ["Q8WYP5", -1.1402279861545381], ["Q92522", -1.1402279861545381], ["Q969X6", -1.1402279861545381], ["Q96CD2", -1.1402279861545381], ["Q96GQ7", -1.1402279861545381], ["Q96JM3", -1.1402279861545381], ["Q96N66", -1.1402279861545381], ["Q96T23", -1.1402279861545381], ["Q9H1E5", -1.1402279861545381], ["Q9H2Y7", -1.1402279861545381], ["Q9NQS7", -1.1402279861545381], ["Q9NW13", -1.1402279861545381], ["Q9P032", -1.1402279861545381], ["Q9P2I0", -1.1402279861545381], ["Q9Y2X3", -1.1402279861545381], ["O14925", -1.1961240878131856], ["O15260", -1.1961240878131856], ["O15550", -1.1961240878131856], ["O60870", -1.1961240878131856], ["O75152", -1.1961240878131856], ["O75503", -1.1961240878131856], ["O94762", -1.1961240878131856], ["O96000", -1.1961240878131856], ["O96005", -1.1961240878131856], ["P04062", -1.1961240878131856], ["P05023", -1.1961240878131856], ["P09471", -1.1961240878131856], ["P13073", -1.1961240878131856], ["P21953", -1.1961240878131856], ["P22626", -1.1961240878131856], ["P27797", -1.1961240878131856], ["P38432", -1.1961240878131856], ["P51532", -1.1961240878131856], ["P62875", -1.1961240878131856], ["Q14137", -1.1961240878131856], ["Q14676", -1.1961240878131856], ["Q5QJE6", -1.1961240878131856], ["Q68EM7", -1.1961240878131856], ["Q6P2Q9", -1.1961240878131856], ["Q7Z6E9", -1.1961240878131856], ["Q8IWA0", -1.1961240878131856], ["Q8N3U4", -1.1961240878131856], ["Q8N766", -1.1961240878131856], ["Q8NCN5", -1.1961240878131856], ["Q92621", -1.1961240878131856], ["Q96CB9", -1.1961240878131856], ["Q96T58", -1.1961240878131856], ["Q9BZL1", -1.1961240878131856], ["Q9H1A4", -1.1961240878131856], ["Q9NRL2", -1.1961240878131856], ["Q9NVP1", -1.1961240878131856], ["Q9UBW7", -1.1961240878131856], ["Q9UIG0", -1.1961240878131856], ["Q9UQ35", -1.1961240878131856], ["Q9Y2X9", -1.1961240878131856], ["O00422", -1.2516704629162527], ["O00483", -1.2516704629162527], ["O43149", -1.2516704629162527], ["O43818", -1.2516704629162527], ["O60313", -1.2516704629162527], ["O75928", -1.2516704629162527], ["O95819", -1.2516704629162527], ["P07355", -1.2516704629162527], ["P11182", -1.2516704629162527], ["P28288", -1.2516704629162527], ["P48449", -1.2516704629162527], ["P78310", -1.2516704629162527], ["P82650", -1.2516704629162527], ["P82979", -1.2516704629162527], ["Q14739", -1.2516704629162527], ["Q15392", -1.2516704629162527], ["Q16629", -1.2516704629162527], ["Q5C9Z4", -1.2516704629162527], ["Q709F0", -1.2516704629162527], ["Q8N2G8", -1.2516704629162527], ["Q8N5C6", -1.2516704629162527], ["Q92896", -1.2516704629162527], ["Q96L73", -1.2516704629162527], ["Q9BU76", -1.2516704629162527], ["Q9H7N4", -1.2516704629162527], ["Q9NUL7", -1.2516704629162527], ["Q9NWU5", -1.2516704629162527], ["Q9UNF0", -1.2516704629162527], ["Q9UNX4", -1.2516704629162527], ["Q9Y2Q5", -1.2516704629162527], ["Q9Y3E5", -1.2516704629162527], ["O15270", -1.3068725682190063], ["O75531", -1.3068725682190063], ["O95985", -1.3068725682190063], ["P02545", -1.3068725682190063], ["P28370", -1.3068725682190063], ["P31483", -1.3068725682190063], ["P31942", -1.3068725682190063], ["P36776", -1.3068725682190063], ["P62316", -1.3068725682190063], ["Q07157", -1.3068725682190063], ["Q14151", -1.3068725682190063], ["Q32NB8", -1.3068725682190063], ["Q5SRE5", -1.3068725682190063], ["Q68E01", -1.3068725682190063], ["Q7RTV0", -1.3068725682190063], ["Q8N5F7", -1.3068725682190063], ["Q8TDD1", -1.3068725682190063], ["Q8WVC6", -1.3068725682190063], ["Q93050", -1.3068725682190063], ["Q96MF7", -1.3068725682190063], ["Q9H9T3", -1.3068725682190063], ["Q9HD20", -1.3068725682190063], ["Q9NQT4", -1.3068725682190063], ["Q9NWH9", -1.3068725682190063], ["Q9UHG3", -1.3068725682190063], ["Q9UK61", -1.3068725682190063], ["Q9UKN8", -1.3068725682190063], ["Q9UL25", -1.3068725682190063], ["Q9UPN9", -1.3068725682190063], ["Q9Y2K7", -1.3068725682190063], ["Q9Y4L1", -1.3068725682190063], ["O43390", -1.3617357252849012], ["O60645", -1.3617357252849012], ["O95235", -1.3617357252849012], ["O95602", -1.3617357252849012], ["O95674", -1.3617357252849012], ["P07237", -1.3617357252849012], ["P11387", -1.3617357252849012], ["P28838", -1.3617357252849012], ["P30260", -1.3617357252849012], ["P41223", -1.3617357252849012], ["P49590", -1.3617357252849012], ["P61803", -1.3617357252849012], ["P78549", -1.3617357252849012], ["Q13523", -1.3617357252849012], ["Q15041", -1.3617357252849012], ["Q15269", -1.3617357252849012], ["Q15910", -1.3617357252849012], ["Q53T59", -1.3617357252849012], ["Q567V2", -1.3617357252849012], ["Q5JPH6", -1.3617357252849012], ["Q5UIP0", -1.3617357252849012], ["Q7Z3B4", -1.3617357252849012], ["Q8NHU6", -1.3617357252849012], ["Q8TAE8", -1.3617357252849012], ["Q8WXH0", -1.3617357252849012], ["Q99590", -1.3617357252849012], ["Q9BZG8", -1.3617357252849012], ["Q9NXE4", -1.3617357252849012], ["Q9P275", -1.3617357252849012], ["Q9Y3T9", -1.3617357252849012], ["Q9Y4P3", -1.3617357252849012], ["Q9Y5Q9", -1.3617357252849012], ["O15235", -1.4162651250521006], ["O75915", -1.4162651250521006], ["P04637", -1.4162651250521006], ["P09417", -1.4162651250521006], ["P30837", -1.4162651250521006], ["Q04837", -1.4162651250521006], ["Q07021", -1.4162651250521006], ["Q12846", -1.4162651250521006], ["Q13151", -1.4162651250521006], ["Q14980", -1.4162651250521006], ["Q15428", -1.4162651250521006], ["Q1KMD3", -1.4162651250521006], ["Q53EZ4", -1.4162651250521006], ["Q8IY81", -1.4162651250521006], ["Q8IZ81", -1.4162651250521006], ["Q8N201", -1.4162651250521006], ["Q8TF46", -1.4162651250521006], ["Q99943", -1.4162651250521006], ["Q9BZE9", -1.4162651250521006], ["Q9NV31", -1.4162651250521006], ["P11388", -1.4704658322054096], ["P13667", -1.4704658322054096], ["P23246", -1.4704658322054096], ["P46977", -1.4704658322054096], ["P51991", -1.4704658322054096], ["Q00059", -1.4704658322054096], ["Q00839", -1.4704658322054096], ["Q01970", -1.4704658322054096], ["Q02880", -1.4704658322054096], ["Q08211", -1.4704658322054096], ["Q14690", -1.4704658322054096], ["Q15375", -1.4704658322054096], ["Q69YN4", -1.4704658322054096], ["Q6GYQ0", -1.4704658322054096], ["Q7L5Y9", -1.4704658322054096], ["Q8TED0", -1.4704658322054096], ["Q9BQG0", -1.4704658322054096], ["Q9UBM7", -1.4704658322054096], ["Q9Y6N1", -1.4704658322054096], ["O75027", -1.5243427893635577], ["O95470", -1.5243427893635577], ["P11474", -1.5243427893635577], ["P30414", -1.5243427893635577], ["P38398", -1.5243427893635577], ["P46013", -1.5243427893635577], ["P48651", -1.5243427893635577], ["P82921", -1.5243427893635577], ["Q15084", -1.5243427893635577], ["Q15459", -1.5243427893635577], ["Q5BKZ1", -1.5243427893635577], ["Q5JTJ3", -1.5243427893635577], ["Q5SY16", -1.5243427893635577], ["Q8NFQ8", -1.5243427893635577], ["Q9H583", -1.5243427893635577], ["Q9UKM9", -1.5243427893635577], ["Q9Y2I1", -1.5243427893635577], ["O00767", -1.5779008210912606], ["O15226", -1.5779008210912606], ["P08559", -1.5779008210912606], ["Q14692", -1.5779008210912606], ["Q5ST30", -1.5779008210912606], ["Q5VUA4", -1.5779008210912606], ["Q8NCE2", -1.5779008210912606], ["Q8NI60", -1.5779008210912606], ["Q92785", -1.5779008210912606], ["Q9BXY0", -1.5779008210912606], ["Q9NVT9", -1.5779008210912606], ["Q9NY61", -1.5779008210912606], ["Q9Y3Y2", -1.5779008210912606], ["Q9Y5L4", -1.5779008210912606], ["O14497", -1.6311446377448497], ["P05387", -1.6311446377448497], ["P15289", -1.6311446377448497], ["P61619", -1.6311446377448497], ["P62995", -1.6311446377448497], ["Q15287", -1.6311446377448497], ["Q15424", -1.6311446377448497], ["Q16625", -1.6311446377448497], ["Q8NI27", -1.6311446377448497], ["Q8WTT2", -1.6311446377448497], ["Q9UGU0", -1.6311446377448497], ["O60831", -1.6840788391598114], ["P98175", -1.6840788391598114], ["Q49A26", -1.6840788391598114], ["Q86U42", -1.6840788391598114], ["Q8N122", -1.6840788391598114], ["Q8WTV0", -1.6840788391598114], ["Q96HW7", -1.6840788391598114], ["Q9UBC3", -1.6840788391598114], ["Q9ULK4", -1.6840788391598114], ["Q9Y4F1", -1.6840788391598114], ["P0DP25", -1.7367079181880423], ["Q14257", -1.7367079181880423], ["Q15293", -1.7367079181880423], ["Q8WWC4", -1.7367079181880423], ["Q9H3H5", -1.7367079181880423], ["Q9HC52", -1.7367079181880423], ["Q9NW64", -1.7367079181880423], ["Q9P2N5", -1.7367079181880423], ["Q9P2S5", -1.7367079181880423], ["Q9UJX5", -1.7367079181880423], ["O00401", -1.7890362640922026], ["O60318", -1.7890362640922026], ["P04179", -1.7890362640922026], ["P07910", -1.7890362640922026], ["P42858", -1.7890362640922026], ["Q13769", -1.7890362640922026], ["Q14156", -1.7890362640922026], ["Q15427", -1.7890362640922026], ["Q16512", -1.7890362640922026], ["Q5ZPR3", -1.7890362640922026], ["Q8NF91", -1.7890362640922026], ["Q8TCJ2", -1.7890362640922026], ["Q96FK6", -1.7890362640922026], ["Q96KA5", -1.7890362640922026], ["Q9NYH9", -1.7890362640922026], ["Q9Y3A4", -1.7890362640922026], ["Q6KC79", -1.8410681658041226], ["Q8N4T8", -1.8410681658041226], ["Q8ND82", -1.8410681658041226], ["Q92804", -1.8410681658041226], ["Q9Y4G8", -1.8410681658041226], ["P35637", -1.8928078150538117], ["O75352", -1.9442593093752722], ["O75691", -1.9442593093752722], ["Q8NB78", -1.9442593093752722], ["P06576", -1.9954266549949233], ["Q9BUN8", -1.9954266549949233], ["Q9C0E2", -1.9954266549949233], ["Q9H5V9", -1.9954266549949233], ["Q9UIF9", -1.9954266549949233], ["Q9Y483", -1.9954266549949233], ["O60613", -2.0463137696082323], ["P08174", -2.0463137696082323], ["P83916", -2.0463137696082323], ["Q02241", -2.0463137696082323], ["Q5T2R2", -2.0463137696082323], ["Q8NC56", -2.0463137696082323], ["Q8TCT9", -2.0463137696082323], ["Q9Y2W1", -2.0463137696082323], ["P09012", -2.0969244850496724], ["P84090", -2.0969244850496724], ["Q96MU7", -2.0969244850496724], ["Q9BSY4", -2.0969244850496724], ["Q9NZW5", -2.0969244850496724], ["O60287", -2.1472625498610114], ["P25098", -2.1472625498610114], ["Q13217", -2.1472625498610114], ["Q6PL18", -2.1472625498610114], ["Q9UJX6", -2.1472625498610114], ["Q9UN81", -2.1472625498610114], ["Q96QD8", -2.1973316317625677], ["Q05932", -2.2471353200318753], ["Q8N9F7", -2.2471353200318753], ["Q96HP4", -2.2471353200318753], ["Q9P2K5", -2.2471353200318753], ["P06748", -2.296677127793886], ["Q14146", -2.296677127793886], ["Q8NCG7", -2.296677127793886], ["Q9UHA3", -2.296677127793886], ["Q504U0", -2.345960494226739], ["Q7L3T8", -2.345960494226739], ["Q9NVR2", -2.345960494226739], ["Q9NZ01", -2.345960494226739], ["Q9NS69", -2.394988786686789], ["O00566", -2.4437653027565207], ["Q14168", -2.4437653027565207], ["Q9BT22", -2.4437653027565207], ["O95218", -2.4922932722186384], ["Q12769", -2.4922932722186384], ["Q15554", -2.4922932722186384], ["Q86SZ2", -2.4922932722186384], ["Q03701", -2.540575858959624], ["P38159", -2.588616162805734], ["O14735", -2.6839820113835446], ["P49750", -2.6839820113835446], ["Q15006", -2.6839820113835446], ["P19338", -2.7313134511020545], ["O15160", -2.8252876664018762], ["P24390", -2.8252876664018762], ["Q8IY17", -2.918362092043995], ["P50416", -2.964568596366209], ["Q13011", -2.964568596366209], ["P17900", -3.0563331697334584], ["Q9H3G5", -3.0563331697334584], ["Q86UT6", -3.1923964436136347], ["Q96C90", -3.1923964436136347], ["P52815", -3.2373382577199403], ["O94919", -3.459056292121288], ["P36639", -3.459056292121288], ["Q96SB8", -3.718821715136778], ["P81605", -3.9721245827300535], ["Q15208", -3.9721245827300535], ["P20700", -5.1167979239050645], ["O75530", -5.228530238599762], ["Q9UMX5", -5.412259974534268]]}, "terms": {"Signaling by robo receptors": {"direction": "up", "overlap": {"value": 92, "mean": 53.89563106796116, "std": 20.749810628210746, "bin": {"bin_50": 3, "bin_100": 7, "bin_250": 21, "bin_500": 43}}, "setsize": {"value": 142, "mean": 136.44174757281553, "std": 4.420166149665581, "bin": {"bin_50": 197, "bin_100": 197, "bin_250": 197, "bin_500": 197}}, "score": {"value": 6.591208370197045, "mean": -0.5803891128880495, "std": 1.9093246617268536, "bin": {"bin_50": 3.345921111609144, "bin_100": 3.96733409610984, "bin_250": 5.136463756507809, "bin_500": 5.856885971171685}}, "pval": {"value": 4.3626108105827056e-11, "mean": 0.4434346526843001, "std": 0.3809851422615608, "bin": {"bin_50": 0.068526741281428, "bin_100": 0.003005976731853, "bin_250": 1.2051030039965853e-08, "bin_500": 3.6613963410436e-17}}, "signature_idxs": {"edge": [565, 513, 26, 514, 515, 34, 529, 527, 526, 48, 62, 71, 604, 605, 603, 86, 84, 568, 602, 104, 115, 601, 590, 681, 680, 133, 713, 151, 149, 150, 679, 153, 651, 652, 180, 656, 179, 201, 224, 225, 226, 227, 721, 720, 738, 258, 832, 300, 855, 297, 797, 298, 299, 293, 803, 799, 818, 817, 815, 814, 813, 816, 379, 923, 912, 370, 373, 905, 904, 903, 902, 901, 907, 407, 899, 405, 894, 416, 412, 477, 958, 457, 458, 986, 456, 468, 471, 469, 470, 982, 464, 974], "full": [1088, 568, 26, 1024, 1628, 1629, 958, 1329, 651, 2036, 652, 3091, 84, 720, 721, 656, 1559, 201, 1483, 149, 405, 34, 1403, 797, 2412, 1038, 456, 1040, 513, 1247, 590, 115, 407, 224, 457, 799, 514, 515, 458, 225, 1042, 973, 1731, 1494, 370, 1255, 2415, 2806, 1409, 1654, 86, 373, 974, 894, 226, 464, 803, 293, 2701, 150, 1258, 1571, 227, 738, 412, 526, 1964, 297, 468, 527, 1661, 899, 151, 1189, 813, 1578, 1969, 469, 104, 814, 298, 982, 601, 470, 901, 471, 815, 816, 679, 902, 179, 299, 1350, 817, 818, 416, 1123, 180, 48, 903, 602, 1420, 680, 603, 681, 300, 1124, 133, 604, 605, 904, 2810, 529, 379, 1050, 153, 1190, 1666, 905, 1268, 258, 1128, 2355, 986, 907, 1276, 2358, 912, 3095, 832, 477, 3129, 1515, 923, 71, 855, 1209, 2093, 62, 713, 565, 1943]}}, "Processing of capped intron containing pre mrna": {"direction": "dw", "overlap": {"value": 95, "mean": 61.44660194174757, "std": 22.544983363510543, "bin": {}}, "setsize": {"value": 179, "mean": 182.83009708737865, "std": 8.980305689776722, "bin": {}}, "score": {"value": -6.504378606809445, "mean": -0.6525536485470969, "std": 1.3401481761909957, "bin": {}}, "pval": {"value": 7.801518568046405e-11, "mean": 0.5600064525169441, "std": 0.3579178268520561, "bin": {}}, "signature_idxs": {"edge": [2532, 2528, 2527, 3088, 2603, 3098, 3094, 3095, 2621, 2627, 3104, 3117, 2594, 3128, 2567, 2590, 3126, 3124, 2584, 2668, 3142, 2676, 3160, 2682, 2657, 2629, 2630, 2632, 2639, 2640, 2641, 3189, 3193, 2726, 2688, 2691, 2695, 2698, 2702, 2779, 2771, 2773, 2781, 2782, 2775, 2747, 2755, 2761, 2792, 2799, 2805, 2884, 2355, 2850, 2849, 2851, 2856, 2339, 2909, 2338, 2915, 2341, 2353, 2924, 2904, 2437, 2890, 2429, 2900, 2942, 2939, 2422, 2421, 2420, 2415, 2971, 2499, 2965, 2969, 2510, 3009, 2457, 2988, 2467, 2997, 2479, 3030, 3028, 2551, 3049, 3044, 2537, 3046, 3068, 2530], "full": [2629, 2792, 1474, 2187, 1635, 2567, 2988, 1794, 1475, 2630, 507, 1168, 2457, 2632, 448, 2890, 2849, 1948, 2850, 2851, 2688, 1479, 1031, 2747, 290, 577, 359, 3124, 2467, 3160, 2799, 2691, 1804, 657, 2639, 659, 2640, 1102, 2695, 2038, 2641, 2900, 2698, 1565, 2124, 2338, 2339, 2856, 3142, 2805, 669, 3193, 2415, 2997, 2341, 2755, 2702, 808, 3044, 1816, 1964, 740, 2527, 202, 2204, 2049, 2528, 1662, 1580, 2420, 152, 2965, 2421, 1663, 2904, 3094, 2136, 2939, 2054, 2422, 3046, 606, 2584, 1584, 2057, 2353, 3049, 2355, 2657, 3189, 2530, 2059, 3028, 2479, 155, 2761, 2590, 2060, 3126, 2532, 1901, 2594, 3095, 105, 67, 1750, 3128, 3030, 3068, 1905, 2537, 2942, 1908, 2429, 2969, 2909, 1201, 2971, 3009, 3104, 1688, 1203, 1605, 2603, 1068, 2771, 1606, 2499, 1759, 2231, 2437, 3098, 2073, 1850, 2773, 1997, 1370, 1998, 2915, 2775, 1291, 1696, 2551, 2079, 1528, 2668, 1001, 2082, 2779, 2781, 1147, 2235, 2782, 2676, 242, 1613, 2726, 1858, 192, 704, 2303, 2306, 3117, 2884, 1217, 2621, 2020, 2024, 1623, 2312, 2103, 1158, 2924, 2510, 2627, 1318, 3088, 2682, 1943]}}, "Regulation of expression of slits and robos": {"direction": "up", "overlap": {"value": 81, "mean": 48.00728155339806, "std": 20.419566225634124, "bin": {"bin_50": 2, "bin_100": 6, "bin_250": 19, "bin_500": 41}}, "setsize": {"value": 125, "mean": 122.56796116504854, "std": 3.037427168561756, "bin": {"bin_50": 155, "bin_100": 155, "bin_250": 155, "bin_500": 155}}, "score": {"value": 6.4871685447950265, "mean": -0.5194973845089386, "std": 1.9506179546475584, "bin": {"bin_50": 2.7795855931024893, "bin_100": 4.307425849751028, "bin_250": 5.986000513742615, "bin_500": 7.542400859917847}}, "pval": {"value": 8.746447804663624e-11, "mean": 0.4369419093856738, "std": 0.3864092465775431, "bin": {"bin_50": 0.1706177828799348, "bin_100": 0.0039291120395458, "bin_250": 6.12570665694535e-09, "bin_500": 1.1425287824847006e-19}}, "signature_idxs": {"edge": [565, 513, 26, 514, 515, 529, 527, 526, 48, 62, 71, 604, 605, 603, 86, 84, 568, 602, 104, 115, 601, 590, 681, 680, 133, 713, 151, 149, 150, 679, 153, 651, 180, 656, 179, 224, 225, 226, 227, 721, 738, 258, 832, 300, 855, 297, 797, 298, 299, 293, 803, 799, 818, 817, 815, 814, 813, 816, 379, 912, 370, 373, 905, 903, 902, 901, 907, 407, 899, 405, 416, 412, 477, 456, 457, 458, 468, 471, 469, 470, 464], "full": [1088, 568, 26, 1024, 1629, 958, 651, 2036, 3091, 84, 721, 656, 1559, 149, 405, 797, 2412, 1038, 456, 1040, 513, 1247, 590, 115, 407, 224, 457, 799, 514, 515, 458, 225, 1042, 973, 1494, 370, 1255, 2415, 2806, 1409, 1654, 86, 373, 974, 894, 226, 464, 803, 293, 2701, 150, 1258, 1571, 227, 738, 412, 526, 1964, 297, 468, 527, 899, 151, 1189, 813, 1578, 469, 104, 814, 298, 982, 601, 470, 901, 471, 815, 816, 679, 902, 179, 299, 1350, 817, 818, 416, 1123, 180, 48, 903, 602, 1420, 680, 603, 681, 300, 1124, 133, 604, 605, 2810, 529, 379, 1050, 153, 1666, 905, 1268, 258, 1128, 2355, 907, 1276, 2358, 912, 3095, 832, 477, 71, 855, 1209, 2093, 62, 713, 565, 1943]}}, "Metabolism of amino acids and derivatives": {"direction": "up", "overlap": {"value": 102, "mean": 65.06796116504854, "std": 24.87493460436243, "bin": {"bin_50": 2, "bin_100": 9, "bin_250": 28, "bin_500": 52}}, "setsize": {"value": 195, "mean": 189.54368932038835, "std": 6.400131520234074, "bin": {"bin_50": 281, "bin_100": 281, "bin_250": 281, "bin_500": 281}}, "score": {"value": 5.914008761345611, "mean": -0.7041043859287429, "std": 1.444416727789915, "bin": {"bin_50": 1.5050713032868146, "bin_100": 3.6121323529411766, "bin_250": 4.8771110312612285, "bin_500": 4.820999862925177}}, "pval": {"value": 3.338801132385652e-09, "mean": 0.4762547421245938, "std": 0.3613418136098282, "bin": {"bin_50": 0.3929194268036308, "bin_100": 0.0015981716153825, "bin_250": 1.8746043647044412e-10, "bin_500": 3.079823209805618e-17}}, "signature_idxs": {"edge": [565, 513, 26, 506, 514, 515, 529, 527, 526, 48, 58, 524, 62, 71, 604, 81, 88, 605, 86, 84, 584, 568, 602, 104, 115, 601, 590, 588, 144, 128, 134, 681, 680, 133, 713, 151, 150, 679, 153, 651, 180, 656, 170, 179, 216, 196, 716, 222, 750, 224, 225, 226, 227, 721, 732, 254, 738, 249, 846, 258, 300, 855, 297, 797, 298, 299, 293, 803, 799, 818, 817, 815, 814, 813, 816, 379, 916, 912, 361, 370, 373, 875, 905, 903, 902, 901, 907, 899, 407, 405, 897, 416, 412, 499, 456, 457, 458, 468, 471, 469, 470, 464], "full": [1088, 568, 26, 1024, 1629, 1228, 506, 958, 249, 196, 170, 1553, 2035, 651, 2748, 128, 2117, 716, 2405, 875, 1643, 3091, 84, 1481, 1957, 965, 3078, 721, 656, 3023, 2578, 1729, 1880, 2934, 361, 2692, 1101, 584, 405, 1884, 1243, 797, 2412, 1038, 456, 222, 1040, 2899, 2195, 513, 588, 2336, 254, 1247, 590, 115, 407, 224, 457, 2644, 799, 514, 515, 458, 225, 2522, 1042, 1650, 1107, 1887, 2855, 973, 732, 1494, 2044, 370, 1255, 2580, 2806, 1409, 1654, 1182, 86, 373, 1343, 974, 894, 226, 464, 803, 293, 2701, 1410, 150, 1258, 1412, 1571, 2344, 524, 227, 738, 412, 526, 1416, 88, 897, 1820, 297, 1048, 2347, 468, 527, 899, 151, 1189, 813, 1349, 1578, 469, 104, 814, 298, 982, 601, 470, 901, 471, 815, 816, 679, 902, 179, 299, 817, 818, 416, 1123, 180, 48, 903, 602, 1420, 680, 681, 300, 1124, 133, 604, 605, 2810, 529, 2209, 379, 1050, 153, 1665, 2055, 1666, 905, 258, 1128, 1428, 81, 750, 907, 134, 2358, 912, 1594, 916, 1984, 2286, 1066, 58, 846, 71, 2156, 1697, 2610, 855, 1209, 1297, 1765, 144, 2302, 1772, 1468, 499, 2392, 2622, 2447, 62, 713, 565, 216]}}, "Eukaryotic translation initiation": {"direction": "up", "overlap": {"value": 74, "mean": 45.19417475728155, "std": 15.071066765335097, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 29}}, "setsize": {"value": 101, "mean": 100.27669902912622, "std": 1.8144888222625024, "bin": {"bin_50": 116, "bin_100": 116, "bin_250": 116, "bin_500": 116}}, "score": {"value": 5.828203309875358, "mean": -0.7708270245582552, "std": 2.0151499677382354, "bin": {"bin_50": 1.817391304347826, "bin_100": 2.7610619469026547, "bin_250": 3.9012208657047727, "bin_500": 6.830845771144278}}, "pval": {"value": 5.602729636229896e-09, "mean": 0.3856475380014496, "std": 0.3857325415106563, "bin": {"bin_50": 0.4299325182794405, "bin_100": 0.1030183046019041, "bin_250": 0.0005146269697812, "bin_500": 1.4630326691932784e-13}}, "signature_idxs": {"edge": [974, 741, 681, 680, 133, 565, 513, 1086, 836, 150, 679, 153, 154, 1038, 905, 903, 529, 300, 901, 405, 899, 525, 48, 180, 902, 894, 1050, 656, 418, 416, 412, 1042, 299, 293, 803, 670, 799, 349, 604, 1128, 751, 818, 825, 605, 86, 815, 581, 84, 817, 813, 954, 816, 450, 379, 456, 457, 957, 464, 968, 602, 468, 104, 471, 226, 1124, 395, 469, 470, 721, 982, 601, 973, 1123, 359], "full": [954, 1393, 957, 1947, 1330, 450, 581, 3091, 84, 359, 721, 656, 1559, 405, 2412, 1038, 456, 1561, 513, 968, 1247, 457, 799, 1042, 973, 1494, 1255, 2806, 1409, 1654, 670, 86, 974, 894, 226, 464, 803, 293, 2701, 150, 1571, 525, 412, 741, 1891, 1968, 1119, 1264, 468, 899, 1189, 813, 1578, 469, 104, 982, 601, 470, 901, 471, 815, 816, 679, 902, 299, 817, 818, 416, 1123, 180, 48, 903, 602, 1420, 680, 681, 300, 1124, 133, 604, 605, 2810, 529, 379, 1050, 153, 1666, 905, 1268, 1128, 154, 751, 1590, 418, 825, 836, 349, 395, 1864, 1086, 565]}}, "Nervous system development": {"direction": "up", "overlap": {"value": 112, "mean": 72.11893203883496, "std": 29.786749038405222, "bin": {"bin_50": 4, "bin_100": 8, "bin_250": 28, "bin_500": 54}}, "setsize": {"value": 221, "mean": 210.9927184466019, "std": 11.960998326208504, "bin": {"bin_50": 443, "bin_100": 443, "bin_250": 443, "bin_500": 443}}, "score": {"value": 5.821269488766753, "mean": -0.4831722305170725, "std": 1.4364728531430393, "bin": {"bin_50": 1.965679574791192, "bin_100": 1.952658835417456, "bin_250": 2.923592552026287, "bin_500": 2.9104773153616343}}, "pval": {"value": 5.840231253307979e-09, "mean": 0.5473670515892652, "std": 0.3670615320407082, "bin": {"bin_50": 0.162664879506444, "bin_100": 0.0658003669541885, "bin_250": 3.295045288200425e-06, "bin_500": 3.177617345312542e-10}}, "signature_idxs": {"edge": [7, 565, 513, 26, 514, 515, 34, 516, 531, 529, 527, 526, 48, 62, 71, 604, 605, 603, 86, 582, 84, 568, 602, 104, 115, 116, 601, 590, 143, 681, 680, 133, 158, 713, 151, 149, 150, 679, 153, 677, 651, 657, 652, 188, 180, 642, 656, 179, 675, 201, 236, 776, 219, 224, 225, 226, 227, 721, 720, 744, 738, 258, 304, 832, 302, 300, 855, 297, 797, 298, 299, 293, 803, 799, 790, 818, 822, 817, 815, 814, 813, 812, 816, 379, 923, 364, 912, 370, 373, 878, 910, 905, 904, 903, 401, 901, 907, 899, 407, 405, 902, 416, 412, 477, 456, 457, 458, 468, 471, 469, 470, 464], "full": [1088, 568, 26, 3121, 1024, 642, 1628, 1629, 1631, 1166, 1717, 790, 958, 2257, 1329, 651, 2036, 2796, 2635, 1641, 1098, 2572, 652, 1726, 401, 3091, 84, 2576, 720, 1237, 1238, 219, 7, 878, 721, 656, 1558, 2517, 657, 1559, 201, 582, 1483, 149, 1037, 405, 34, 1403, 797, 2412, 1038, 2471, 456, 1485, 364, 1040, 513, 1041, 1247, 590, 115, 407, 224, 1105, 457, 799, 514, 515, 458, 225, 516, 1042, 973, 1731, 1408, 1494, 1568, 2200, 370, 1179, 1255, 2415, 2806, 1409, 1654, 86, 373, 974, 894, 226, 464, 803, 293, 2701, 1183, 150, 1258, 1571, 227, 738, 1259, 1415, 412, 2903, 526, 1964, 675, 297, 677, 744, 468, 527, 1661, 1577, 812, 899, 151, 1189, 813, 1578, 1969, 469, 104, 814, 298, 982, 601, 470, 901, 471, 815, 816, 679, 902, 179, 299, 1350, 817, 818, 416, 1123, 180, 48, 903, 602, 1420, 680, 603, 681, 300, 1124, 133, 604, 605, 1266, 904, 2052, 2810, 529, 1421, 302, 379, 1050, 153, 531, 1824, 2269, 1190, 1666, 304, 905, 1268, 1896, 116, 258, 1128, 2355, 822, 986, 907, 2811, 1827, 1276, 1673, 2531, 236, 910, 2358, 912, 3095, 1355, 832, 477, 3051, 2278, 3129, 2488, 158, 2815, 1686, 1515, 923, 71, 1371, 1695, 188, 2000, 1144, 1145, 855, 1209, 776, 143, 2093, 1935, 2980, 62, 713, 565, 1319, 1943]}}, "Mitotic g1 phase and g1 s transition": {"direction": "up", "overlap": {"value": 53, "mean": 22.104368932038835, "std": 11.678595487596883, "bin": {"bin_50": 2, "bin_100": 4, "bin_250": 14, "bin_500": 24}}, "setsize": {"value": 79, "mean": 76.02184466019418, "std": 5.354610434747646, "bin": {"bin_50": 143, "bin_100": 143, "bin_250": 143, "bin_500": 143}}, "score": {"value": 5.642539027953381, "mean": 0.5927262006732629, "std": 1.3736272695770486, "bin": {"bin_50": 3.019767617323072, "bin_100": 3.0164331692540705, "bin_250": 4.553965414430531, "bin_500": 4.075736623763429}}, "pval": {"value": 1.6756053699709077e-08, "mean": 0.5705780900762646, "std": 0.3846948779804449, "bin": {"bin_50": 0.150329772144836, "bin_100": 0.0502965454501162, "bin_250": 9.57968471898827e-06, "bin_500": 9.532633491856932e-08}}, "signature_idxs": {"edge": [370, 373, 912, 738, 737, 252, 131, 21, 258, 713, 260, 26, 876, 151, 511, 514, 515, 519, 651, 528, 181, 653, 909, 527, 526, 407, 62, 855, 179, 297, 797, 298, 802, 607, 71, 665, 201, 821, 814, 381, 458, 570, 568, 219, 731, 224, 225, 726, 227, 115, 591, 590, 589], "full": [1088, 568, 26, 1024, 1629, 958, 1796, 570, 651, 653, 876, 1955, 511, 219, 1482, 3040, 1241, 252, 201, 726, 1242, 797, 1040, 589, 1489, 590, 115, 407, 224, 591, 514, 515, 458, 225, 665, 1566, 519, 731, 1407, 1252, 21, 370, 802, 373, 1258, 737, 131, 227, 738, 1186, 526, 297, 2419, 527, 151, 814, 298, 179, 528, 181, 1051, 258, 607, 821, 907, 381, 909, 1057, 260, 1591, 912, 71, 855, 1209, 2015, 2305, 1156, 62, 713]}}, "Metabolism of lipids": {"direction": "dw", "overlap": {"value": 82, "mean": 47.21601941747573, "std": 16.76057659641467, "bin": {}}, "setsize": {"value": 176, "mean": 182.9902912621359, "std": 20.451455734561765, "bin": {}}, "score": {"value": -5.4174011154060215, "mean": 0.7669400545274999, "std": 1.5920609507025254, "bin": {}}, "pval": {"value": 6.047157406993877e-08, "mean": 0.4573741022352977, "std": 0.4091924181498379, "bin": {}}, "signature_idxs": {"edge": [3061, 3060, 3082, 3076, 2598, 3092, 3109, 2571, 2579, 3138, 2670, 2678, 2673, 3159, 2658, 2656, 3173, 2638, 3183, 2643, 2650, 2646, 3194, 3200, 3201, 3203, 2728, 2739, 2684, 2746, 2292, 2754, 2763, 2317, 2308, 2824, 2265, 2264, 2256, 2253, 2843, 2793, 2798, 2803, 2815, 2813, 2809, 2807, 2877, 2389, 2388, 2865, 2853, 2336, 2857, 2323, 2352, 2895, 2944, 2397, 2398, 2941, 2940, 2936, 2416, 2484, 2490, 2957, 2968, 2509, 2466, 3015, 2460, 2992, 2478, 2549, 3037, 2545, 3057, 2513, 2521, 3065], "full": [2397, 2513, 247, 2398, 2746, 3076, 2684, 3194, 2323, 2253, 2957, 2111, 2033, 1394, 2256, 2113, 647, 2460, 1798, 1722, 961, 2793, 2853, 874, 1799, 3060, 963, 578, 2571, 2992, 1801, 2895, 2798, 1399, 2191, 1401, 1557, 2466, 1035, 966, 1879, 2638, 3061, 404, 660, 3092, 1174, 2579, 1646, 1403, 3203, 364, 1244, 1960, 2521, 1245, 2643, 1885, 2803, 2336, 1650, 2646, 1652, 2044, 1341, 2045, 2754, 1656, 892, 2807, 2416, 2264, 1184, 2936, 3065, 1045, 1497, 2265, 3201, 2857, 2650, 2131, 2132, 1117, 1346, 1966, 2809, 1821, 1502, 1265, 2207, 983, 1421, 2656, 1267, 2352, 1505, 2478, 1826, 2658, 752, 2763, 117, 1588, 2940, 1058, 2484, 2813, 829, 830, 2941, 1433, 1679, 2221, 1982, 2815, 916, 2968, 1752, 2490, 2143, 1283, 2598, 2944, 543, 2865, 1202, 995, 2545, 3200, 3138, 1845, 3173, 2071, 2824, 3082, 1916, 1522, 1523, 2549, 1694, 2292, 72, 430, 312, 2877, 2670, 1925, 1208, 1378, 1004, 3037, 1300, 2673, 2009, 491, 2728, 164, 2388, 2678, 2389, 3015, 3183, 2308, 2843, 1937, 1619, 3057, 2739, 2021, 3109, 865, 3159, 2509, 2317, 1472]}}, "Selenoamino acid metabolism": {"direction": "up", "overlap": {"value": 67, "mean": 45.359223300970875, "std": 16.116146621354947, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 11, "bin_500": 26}}, "setsize": {"value": 91, "mean": 88.94660194174757, "std": 1.9650003351851577, "bin": {"bin_50": 107, "bin_100": 107, "bin_250": 107, "bin_500": 107}}, "score": {"value": 5.204373788940948, "mean": -1.2269036973447986, "std": 2.2110932203759184, "bin": {"bin_50": 1.9734669811320755, "bin_100": 3.002704326923077, "bin_250": 4.763185654008439, "bin_500": 6.540123456790123}}, "pval": {"value": 1.946518611202556e-07, "mean": 0.3270935993226454, "std": 0.3833177831487697, "bin": {"bin_50": 0.4043878907472013, "bin_100": 0.0857236814467353, "bin_250": 5.578263610647233e-05, "bin_500": 5.547847057241464e-12}}, "signature_idxs": {"edge": [974, 973, 128, 681, 249, 680, 133, 565, 513, 150, 679, 153, 1038, 905, 903, 529, 300, 902, 901, 899, 48, 524, 180, 405, 1048, 1050, 656, 897, 894, 416, 1042, 299, 293, 803, 412, 799, 604, 1128, 196, 818, 605, 86, 817, 84, 815, 813, 816, 379, 456, 457, 464, 1101, 602, 716, 104, 750, 468, 226, 1124, 471, 916, 469, 721, 470, 601, 982, 588], "full": [249, 196, 128, 716, 3091, 84, 1481, 721, 656, 1101, 405, 2412, 1038, 456, 513, 588, 1247, 457, 799, 1042, 2855, 973, 1494, 1255, 2806, 1409, 1654, 1182, 86, 974, 894, 226, 464, 803, 293, 2701, 1410, 150, 1571, 524, 412, 897, 1048, 2347, 468, 899, 1189, 813, 1578, 469, 104, 982, 601, 470, 901, 471, 815, 816, 679, 902, 299, 817, 818, 416, 1123, 180, 48, 903, 602, 1420, 680, 681, 300, 1124, 133, 604, 605, 2810, 529, 379, 1050, 153, 1666, 905, 1128, 1428, 750, 1594, 916, 1468, 565]}}, "Mrna splicing": {"direction": "dw", "overlap": {"value": 68, "mean": 48.28883495145631, "std": 18.528162023337615, "bin": {}}, "setsize": {"value": 138, "mean": 142.3228155339806, "std": 7.100537640996984, "bin": {}}, "score": {"value": -5.145273707296524, "mean": -0.6040586609434766, "std": 1.2901632086040689, "bin": {}}, "pval": {"value": 2.671310389051108e-07, "mean": 0.555878613477235, "std": 0.3655002719916655, "bin": {}}, "signature_idxs": {"edge": [2792, 2422, 2603, 2799, 2421, 2420, 2415, 3094, 3095, 2971, 2627, 2499, 2691, 3104, 2965, 2695, 3117, 2698, 2594, 2884, 2510, 3128, 2567, 2355, 2850, 2849, 2851, 2590, 2457, 3124, 2856, 2988, 2584, 2339, 2467, 2668, 3142, 2909, 2997, 2338, 2479, 2341, 2775, 2353, 3030, 2924, 2747, 3028, 2551, 3160, 2682, 2657, 2904, 3049, 2761, 2630, 2429, 2632, 2900, 3044, 2537, 2640, 2641, 3046, 3068, 3193, 2530, 2942], "full": [2792, 1474, 2187, 1635, 2567, 2988, 1794, 1475, 2630, 507, 1168, 2457, 2632, 448, 2849, 1948, 2850, 2851, 1479, 1031, 2747, 290, 577, 3124, 2467, 3160, 2799, 2691, 1804, 657, 659, 2640, 1102, 2695, 2038, 2641, 2900, 2698, 1565, 2124, 2338, 2339, 2856, 3142, 3193, 2415, 2997, 2341, 808, 3044, 1816, 1964, 740, 2204, 2049, 1662, 1580, 2420, 152, 2965, 2421, 1663, 2904, 3094, 2054, 2422, 3046, 606, 2584, 1584, 2057, 2353, 3049, 2355, 2657, 2530, 2059, 3028, 2479, 155, 2761, 2590, 2060, 1901, 2594, 3095, 105, 67, 1750, 3128, 3030, 3068, 1905, 2537, 2942, 2429, 2909, 1201, 2971, 3104, 1203, 1605, 2603, 1068, 1606, 2499, 1850, 1997, 1370, 1998, 2775, 1291, 1696, 2551, 2668, 2082, 1147, 2235, 242, 1613, 1858, 192, 704, 2303, 3117, 2884, 1217, 2020, 2024, 1623, 2103, 1158, 2924, 2510, 2627, 1318, 2682, 1943]}}, "Neddylation": {"direction": "up", "overlap": {"value": 47, "mean": 21.652912621359224, "std": 10.995736873021038, "bin": {"bin_50": 2, "bin_100": 4, "bin_250": 14, "bin_500": 26}}, "setsize": {"value": 85, "mean": 72.70145631067962, "std": 5.895588099944547, "bin": {"bin_50": 185, "bin_100": 185, "bin_250": 185, "bin_500": 185}}, "score": {"value": 5.142253317548198, "mean": 0.2249049893089814, "std": 1.324302453446783, "bin": {"bin_50": 2.3169398907103824, "bin_100": 2.306717068915382, "bin_250": 3.42075273654221, "bin_500": 3.304738300820808}}, "pval": {"value": 2.71462752552772e-07, "mean": 0.5831751905762216, "std": 0.3688918753546149, "bin": {"bin_50": 0.2230224621726305, "bin_100": 0.1053824969029053, "bin_250": 0.0001658939845036, "bin_500": 1.0305927743868874e-06}}, "signature_idxs": {"edge": [548, 147, 551, 745, 715, 370, 373, 738, 678, 713, 258, 26, 832, 151, 443, 514, 515, 651, 181, 314, 46, 527, 526, 407, 62, 855, 179, 297, 298, 343, 71, 766, 204, 762, 627, 477, 603, 106, 381, 571, 458, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 958, 571, 651, 715, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 678, 745, 151, 2529, 814, 298, 179, 603, 181, 258, 906, 907, 381, 1506, 1057, 1276, 1191, 2061, 2480, 2425, 2358, 204, 912, 1904, 1356, 832, 477, 1197, 762, 1911, 2600, 1139, 343, 71, 766, 1526, 106, 2162, 855, 1209, 548, 551, 314, 627, 2168, 1770, 2390, 147, 1936, 1780, 1014, 46, 1781, 62, 713, 443, 1388, 2846]}}, "Signaling by interleukins": {"direction": "up", "overlap": {"value": 52, "mean": 26.51456310679612, "std": 12.507367985924851, "bin": {"bin_50": 4, "bin_100": 9, "bin_250": 21, "bin_500": 36}}, "setsize": {"value": 108, "mean": 106.8131067961165, "std": 6.646155400677433, "bin": {"bin_50": 248, "bin_100": 248, "bin_250": 248, "bin_500": 248}}, "score": {"value": 5.093467783547898, "mean": 0.2659215907627361, "std": 1.0797762015608217, "bin": {"bin_50": 3.607650273224044, "bin_100": 4.124686192468619, "bin_250": 3.961672068155796, "bin_500": 3.4866454300416563}}, "pval": {"value": 3.515728148756648e-07, "mean": 0.6379218100870152, "std": 0.3618033258723105, "bin": {"bin_50": 0.0307995556084358, "bin_100": 0.0006635705963155, "bin_250": 6.336254741556989e-07, "bin_500": 3.462608225721226e-09}}, "signature_idxs": {"edge": [587, 135, 370, 372, 686, 373, 10, 15, 251, 256, 258, 713, 26, 304, 436, 151, 514, 515, 516, 651, 41, 521, 657, 181, 403, 527, 526, 407, 409, 62, 179, 296, 297, 298, 672, 71, 665, 65, 81, 603, 84, 458, 103, 568, 219, 224, 225, 227, 115, 116, 590, 141], "full": [1544, 1088, 568, 26, 1024, 1629, 2564, 1225, 958, 651, 1727, 3123, 3022, 84, 2576, 2993, 2933, 1237, 1238, 219, 2690, 251, 2411, 1804, 657, 2333, 403, 2470, 1403, 797, 662, 1040, 3213, 2900, 587, 1041, 590, 115, 407, 224, 1105, 2125, 514, 515, 458, 225, 516, 665, 1566, 370, 372, 1495, 15, 409, 521, 672, 373, 65, 1258, 227, 738, 256, 2903, 526, 1738, 740, 296, 297, 527, 1661, 103, 151, 814, 298, 179, 603, 1266, 2348, 181, 41, 304, 116, 258, 1745, 3027, 1826, 81, 986, 907, 1131, 1057, 1592, 2358, 912, 2278, 1196, 135, 2488, 686, 10, 71, 855, 141, 1209, 436, 1314, 62, 713]}}, "Eukaryotic translation elongation": {"direction": "up", "overlap": {"value": 58, "mean": 40.33980582524272, "std": 13.865899638243102, "bin": {"bin_50": 2, "bin_100": 4, "bin_250": 11, "bin_500": 26}}, "setsize": {"value": 77, "mean": 76.70873786407768, "std": 1.3501604935966776, "bin": {"bin_50": 89, "bin_100": 89, "bin_250": 89, "bin_500": 89}}, "score": {"value": 5.078750816994674, "mean": -1.170264854227122, "std": 2.213815111182405, "bin": {"bin_50": 4.9205184641721695, "bin_100": 4.959504643962848, "bin_250": 5.873093151574165, "bin_500": 8.424468657519505}}, "pval": {"value": 3.799246207700961e-07, "mean": 0.3173586097479524, "std": 0.3781772268307828, "bin": {"bin_50": 0.0680396063598938, "bin_100": 0.0108822951588252, "bin_250": 9.66419870753046e-06, "bin_500": 4.9785773006614655e-14}}, "signature_idxs": {"edge": [974, 367, 681, 680, 133, 565, 22, 513, 150, 679, 153, 1038, 905, 903, 529, 300, 902, 901, 405, 48, 899, 180, 894, 1050, 656, 416, 172, 412, 1042, 299, 293, 803, 799, 604, 818, 605, 86, 817, 84, 815, 813, 816, 379, 456, 457, 464, 602, 468, 104, 471, 226, 469, 725, 470, 982, 721, 601, 973], "full": [3091, 84, 721, 656, 725, 405, 2412, 1038, 456, 513, 172, 1247, 457, 367, 799, 1491, 1042, 973, 1494, 1255, 2806, 1409, 1654, 86, 974, 894, 226, 464, 803, 293, 2701, 150, 1571, 412, 468, 899, 1189, 813, 1578, 469, 104, 982, 601, 470, 901, 471, 815, 816, 679, 902, 299, 817, 818, 416, 1123, 180, 48, 903, 602, 1420, 680, 681, 300, 1124, 133, 604, 605, 2810, 529, 379, 1050, 153, 1666, 905, 22, 1128, 565]}}, "Dna replication pre initiation": {"direction": "up", "overlap": {"value": 39, "mean": 16.987864077669904, "std": 9.845276246498855, "bin": {"bin_50": 2, "bin_100": 4, "bin_250": 12, "bin_500": 20}}, "setsize": {"value": 63, "mean": 61.73300970873787, "std": 3.587542857888571, "bin": {"bin_50": 92, "bin_100": 92, "bin_250": 92, "bin_500": 92}}, "score": {"value": 5.01754477196167, "mean": 0.4288945668380205, "std": 1.230696609236802, "bin": {"bin_50": 4.755082742316785, "bin_100": 4.7889952153110045, "bin_250": 6.272033898305085, "bin_500": 5.593909809390981}}, "pval": {"value": 5.233600750511256e-07, "mean": 0.5957541730468855, "std": 0.3684137615844171, "bin": {"bin_50": 0.0720814043883259, "bin_100": 0.0121831039178989, "bin_250": 2.1262294697935726e-06, "bin_500": 1.2822688490157492e-08}}, "signature_idxs": {"edge": [370, 373, 738, 737, 131, 21, 258, 713, 260, 26, 151, 514, 515, 651, 648, 407, 526, 527, 62, 855, 179, 297, 797, 298, 607, 71, 814, 102, 458, 570, 568, 731, 224, 225, 227, 115, 591, 590, 589], "full": [1088, 568, 26, 1024, 1629, 958, 1796, 570, 648, 651, 1482, 1242, 797, 1040, 589, 1489, 590, 115, 407, 224, 591, 514, 515, 458, 225, 731, 1407, 1252, 21, 370, 373, 1258, 737, 131, 227, 738, 1186, 526, 102, 297, 2419, 527, 151, 814, 298, 179, 1351, 258, 607, 907, 260, 1591, 1058, 2358, 912, 71, 855, 1209, 2015, 2305, 1156, 62, 713]}}, "Response of eif2ak4 gcn2 to amino acid deficiency": {"direction": "up", "overlap": {"value": 57, "mean": 39.550970873786405, "std": 13.761485019110056, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 23}}, "setsize": {"value": 77, "mean": 76.03155339805825, "std": 1.5173669435319213, "bin": {"bin_50": 94, "bin_100": 94, "bin_250": 94, "bin_500": 94}}, "score": {"value": 4.970626968756986, "mean": -1.127048342201767, "std": 2.220942857496925, "bin": {"bin_50": 2.252240143369176, "bin_100": 3.4361263736263736, "bin_250": 4.369529904011814, "bin_500": 6.565485544848036}}, "pval": {"value": 6.673674073174395e-07, "mean": 0.3185079045659907, "std": 0.3803423215749384, "bin": {"bin_50": 0.3654998372428625, "bin_100": 0.0632302441478985, "bin_250": 0.000452953691518, "bin_500": 8.156854023844305e-11}}, "signature_idxs": {"edge": [974, 681, 680, 133, 565, 513, 150, 679, 153, 1038, 905, 903, 529, 300, 902, 901, 405, 48, 899, 180, 894, 1050, 656, 416, 412, 1042, 299, 293, 803, 670, 799, 604, 818, 605, 86, 817, 581, 84, 815, 813, 965, 816, 379, 456, 457, 464, 602, 468, 104, 471, 226, 469, 470, 982, 721, 601, 973], "full": [581, 3091, 84, 965, 721, 656, 405, 2412, 1038, 456, 1561, 513, 1247, 457, 799, 1042, 973, 1494, 1255, 2806, 1409, 1654, 670, 86, 974, 894, 226, 464, 803, 293, 2701, 150, 1571, 412, 468, 899, 1189, 813, 1578, 469, 104, 982, 601, 470, 901, 471, 815, 816, 679, 902, 299, 817, 818, 416, 1123, 180, 48, 903, 602, 1420, 680, 681, 300, 1124, 133, 604, 605, 2810, 529, 379, 1050, 153, 1666, 905, 1128, 1446, 565]}}, "Hedgehog off state": {"direction": "up", "overlap": {"value": 37, "mean": 15.740291262135925, "std": 8.054006294440956, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 13, "bin_500": 22}}, "setsize": {"value": 53, "mean": 51.0752427184466, "std": 2.7424510136822824, "bin": {"bin_50": 96, "bin_100": 96, "bin_250": 96, "bin_500": 96}}, "score": {"value": 4.922598703484469, "mean": 0.6256619133963464, "std": 1.3127807939810612, "bin": {"bin_50": 2.204385964912281, "bin_100": 3.361559139784946, "bin_250": 6.574980774160472, "bin_500": 6.010901657960481}}, "pval": {"value": 8.540246525081624e-07, "mean": 0.5308625548821857, "std": 0.3772173866259285, "bin": {"bin_50": 0.3716405295483306, "bin_100": 0.0664874170634557, "bin_250": 5.114228768736508e-07, "bin_500": 8.201574904517287e-10}}, "signature_idxs": {"edge": [730, 143, 370, 373, 738, 258, 713, 26, 151, 514, 515, 651, 181, 302, 401, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 236, 603, 770, 814, 458, 568, 220, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 958, 651, 401, 220, 1483, 1403, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 730, 370, 373, 1258, 227, 738, 1259, 526, 297, 527, 151, 814, 298, 179, 603, 181, 302, 258, 907, 1057, 236, 2358, 912, 1995, 71, 770, 855, 1209, 143, 62, 713, 1320]}}, "Mitotic g2 g2 m phases": {"direction": "up", "overlap": {"value": 51, "mean": 25.512135922330096, "std": 11.374146646790262, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 13, "bin_500": 24}}, "setsize": {"value": 91, "mean": 89.70388349514563, "std": 7.343161700072858, "bin": {"bin_50": 186, "bin_100": 186, "bin_250": 186, "bin_500": 186}}, "score": {"value": 4.883610314577864, "mean": 0.5564324413272281, "std": 1.2377579618165189, "bin": {"bin_50": 1.1218468468468468, "bin_100": 1.692964480874317, "bin_250": 3.1256917968269584, "bin_500": 2.980465697765276}}, "pval": {"value": 1.0416083163035978e-06, "mean": 0.5721896286221594, "std": 0.3831596446417351, "bin": {"bin_50": 0.5951682859746134, "bin_100": 0.2702149669975119, "bin_250": 0.0006084096570213, "bin_500": 1.2033223556180458e-05}}, "signature_idxs": {"edge": [730, 143, 370, 373, 912, 127, 738, 258, 538, 713, 445, 26, 878, 151, 511, 514, 515, 702, 651, 528, 181, 302, 401, 527, 526, 407, 402, 62, 621, 855, 179, 297, 797, 298, 608, 71, 665, 821, 236, 603, 814, 931, 458, 568, 224, 225, 726, 227, 115, 590, 589], "full": [1088, 568, 26, 1024, 1629, 1165, 1945, 1868, 958, 651, 127, 1097, 2402, 401, 3022, 511, 402, 1237, 878, 726, 1403, 797, 1040, 2752, 589, 590, 115, 407, 224, 514, 515, 458, 225, 665, 1566, 730, 370, 1342, 373, 1258, 227, 738, 526, 1818, 297, 527, 1501, 1121, 151, 1122, 2207, 814, 298, 1579, 179, 603, 528, 2135, 181, 302, 258, 821, 907, 2589, 608, 1057, 236, 1748, 1431, 1676, 2358, 912, 1833, 538, 1515, 71, 621, 931, 2162, 855, 1209, 2833, 2297, 143, 702, 1465, 2310, 62, 2448, 713, 445]}}, "Dna replication": {"direction": "up", "overlap": {"value": 50, "mean": 24.50242718446602, "std": 12.317305449092803, "bin": {"bin_50": 2, "bin_100": 4, "bin_250": 15, "bin_500": 30}}, "setsize": {"value": 90, "mean": 88.36650485436893, "std": 5.805851117746023, "bin": {"bin_50": 137, "bin_100": 137, "bin_250": 137, "bin_500": 137}}, "score": {"value": 4.8684129652595445, "mean": 0.2923135263536031, "std": 1.1877285197942282, "bin": {"bin_50": 3.155870764381403, "bin_100": 3.154412346656114, "bin_250": 5.185041863083093, "bin_500": 5.745866283249461}}, "pval": {"value": 1.1249804927615514e-06, "mean": 0.6312906600612657, "std": 0.3655243748981305, "bin": {"bin_50": 0.1403881914917208, "bin_100": 0.044160808858811, "bin_250": 1.1152633426561252e-06, "bin_500": 2.29469131658009e-12}}, "signature_idxs": {"edge": [369, 370, 373, 738, 737, 130, 131, 252, 21, 258, 713, 260, 26, 151, 514, 515, 651, 181, 648, 527, 526, 407, 62, 855, 179, 292, 297, 797, 298, 607, 71, 329, 603, 381, 102, 458, 570, 568, 731, 729, 225, 224, 119, 227, 115, 269, 271, 591, 590, 589], "full": [1088, 568, 26, 1024, 1629, 958, 1796, 570, 648, 651, 1482, 252, 1242, 797, 1104, 1040, 589, 1489, 590, 115, 407, 224, 591, 514, 515, 458, 225, 729, 2996, 731, 1407, 1252, 21, 329, 369, 2043, 370, 130, 292, 1496, 373, 1258, 805, 737, 131, 227, 738, 1186, 526, 102, 297, 2419, 527, 151, 814, 298, 179, 1351, 603, 181, 258, 607, 2588, 907, 381, 1057, 260, 1591, 1058, 2358, 912, 990, 71, 269, 855, 1209, 271, 119, 2919, 2015, 2305, 1156, 2844, 2248, 1782, 3120, 3169, 62, 713, 2790]}}, "Deubiquitination": {"direction": "up", "overlap": {"value": 49, "mean": 21.274271844660195, "std": 11.64961844468234, "bin": {"bin_50": 2, "bin_100": 6, "bin_250": 16, "bin_500": 28}}, "setsize": {"value": 93, "mean": 90.48543689320388, "std": 9.030277095459189, "bin": {"bin_50": 221, "bin_100": 221, "bin_250": 221, "bin_500": 221}}, "score": {"value": 4.837514531829301, "mean": 0.4172727973060445, "std": 1.0784969503501256, "bin": {"bin_50": 1.929078014184397, "bin_100": 2.9653413353338336, "bin_250": 3.27771236333053, "bin_500": 2.93396538419138}}, "pval": {"value": 1.3147277564407034e-06, "mean": 0.5987827475213043, "std": 0.3703499256790007, "bin": {"bin_50": 0.2873388595440179, "bin_100": 0.0204567166081377, "bin_250": 9.644335321857968e-05, "bin_500": 3.2623082008633428e-06}}, "signature_idxs": {"edge": [132, 370, 9, 373, 738, 562, 258, 713, 26, 710, 535, 838, 151, 511, 514, 515, 444, 651, 527, 526, 184, 407, 62, 676, 59, 179, 855, 828, 797, 298, 297, 71, 827, 96, 503, 332, 383, 381, 458, 218, 568, 583, 224, 225, 227, 115, 374, 590, 140], "full": [1088, 568, 26, 1024, 1629, 1392, 958, 218, 651, 1331, 1725, 2330, 3022, 511, 583, 797, 1040, 2801, 590, 115, 407, 224, 514, 515, 458, 225, 1493, 370, 3063, 1655, 373, 2128, 374, 1258, 227, 738, 1499, 526, 132, 1967, 297, 676, 527, 151, 1969, 814, 298, 179, 332, 258, 1747, 907, 381, 1273, 535, 2425, 827, 1354, 828, 2358, 912, 1194, 1196, 383, 184, 1843, 838, 1690, 3145, 1848, 71, 1761, 1921, 1448, 59, 1453, 140, 855, 1209, 2377, 9, 96, 710, 62, 2679, 713, 562, 2394, 444, 1785, 2956, 2628, 503]}}, "Interleukin 1 family signaling": {"direction": "up", "overlap": {"value": 30, "mean": 14.592233009708735, "std": 8.12336542865419, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 12, "bin_500": 22}}, "setsize": {"value": 51, "mean": 49.06310679611651, "std": 3.453701835311694, "bin": {"bin_50": 95, "bin_100": 95, "bin_250": 95, "bin_500": 95}}, "score": {"value": 4.713463543834794, "mean": 0.4308069558259447, "std": 1.3196847762251946, "bin": {"bin_50": 2.2280585106382977, "bin_100": 3.3984375, "bin_250": 6.0434960179701855, "bin_500": 6.0938759065269945}}, "pval": {"value": 2.435413134049824e-06, "mean": 0.5378127516815151, "std": 0.3781683305809454, "bin": {"bin_50": 0.3685774959165274, "bin_100": 0.0648492807338132, "bin_250": 3.002797345103773e-06, "bin_500": 6.61801865594436e-10}}, "signature_idxs": {"edge": [370, 373, 251, 258, 713, 26, 304, 151, 514, 515, 181, 407, 526, 409, 527, 62, 179, 297, 298, 71, 603, 458, 103, 568, 224, 225, 227, 115, 116, 590], "full": [1088, 568, 26, 1024, 1629, 1225, 958, 651, 251, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 409, 373, 1258, 227, 738, 526, 297, 527, 103, 151, 814, 298, 179, 603, 181, 304, 116, 258, 1826, 907, 1131, 1057, 2358, 912, 1196, 71, 855, 1209, 1314, 62, 713]}}, "Ub specific processing proteases": {"direction": "up", "overlap": {"value": 42, "mean": 17.070388349514563, "std": 9.734454714417684, "bin": {"bin_50": 1, "bin_100": 4, "bin_250": 13, "bin_500": 24}}, "setsize": {"value": 74, "mean": 72.1116504854369, "std": 6.256038651254875, "bin": {"bin_50": 151, "bin_100": 151, "bin_250": 151, "bin_500": 151}}, "score": {"value": 4.70932241110936, "mean": 0.5586830572298067, "std": 1.0924507106168106, "bin": {"bin_50": 1.3884722222222223, "bin_100": 2.849982098102399, "bin_250": 3.9324699352451433, "bin_500": 3.815807834147314}}, "pval": {"value": 2.4854165745491485e-06, "mean": 0.5701992170768696, "std": 0.3735968680377643, "bin": {"bin_50": 0.5194592783315142, "bin_100": 0.0591714782529967, "bin_250": 7.751567049096112e-05, "bin_500": 2.737884102579831e-07}}, "signature_idxs": {"edge": [132, 370, 373, 738, 562, 258, 713, 710, 26, 535, 838, 151, 514, 515, 444, 651, 407, 526, 527, 62, 59, 179, 855, 828, 797, 297, 298, 71, 814, 383, 381, 458, 218, 568, 583, 224, 225, 227, 115, 374, 590, 140], "full": [1088, 568, 26, 1024, 1629, 958, 218, 651, 1331, 1725, 3022, 583, 797, 1040, 2801, 590, 115, 407, 224, 514, 515, 458, 225, 1493, 370, 1655, 373, 2128, 374, 1258, 227, 738, 526, 132, 297, 527, 151, 814, 298, 179, 258, 1747, 907, 381, 1273, 535, 2425, 1354, 828, 2358, 912, 1196, 383, 838, 1690, 1848, 71, 1761, 1921, 1448, 59, 1453, 140, 855, 1209, 710, 62, 713, 562, 2394, 444, 1785, 2956, 2628]}}, "Synthesis of dna": {"direction": "up", "overlap": {"value": 48, "mean": 23.16990291262136, "std": 11.716110681669798, "bin": {"bin_50": 2, "bin_100": 4, "bin_250": 14, "bin_500": 29}}, "setsize": {"value": 86, "mean": 82.84708737864078, "std": 5.49919819946737, "bin": {"bin_50": 117, "bin_100": 117, "bin_250": 117, "bin_500": 117}}, "score": {"value": 4.708300256189888, "mean": 0.4375997809997383, "std": 1.2425112242470815, "bin": {"bin_50": 3.712118408880666, "bin_100": 3.720167675826735, "bin_250": 5.718612563272758, "bin_500": 6.75251986819151}}, "pval": {"value": 2.4979097321686794e-06, "mean": 0.6204468538632794, "std": 0.3782848222763735, "bin": {"bin_50": 0.1084777994315797, "bin_100": 0.0269419431031802, "bin_250": 8.696145807003083e-07, "bin_500": 1.8581629193190466e-13}}, "signature_idxs": {"edge": [369, 370, 373, 738, 737, 130, 131, 252, 21, 258, 713, 260, 26, 151, 514, 515, 651, 181, 527, 526, 407, 62, 855, 179, 292, 297, 797, 298, 607, 71, 329, 603, 381, 458, 570, 568, 731, 729, 225, 224, 119, 227, 115, 269, 271, 591, 590, 589], "full": [1088, 568, 26, 1024, 1629, 958, 1796, 570, 651, 1482, 252, 1242, 797, 1104, 1040, 589, 1489, 590, 115, 407, 224, 591, 514, 515, 458, 225, 729, 2996, 731, 1407, 1252, 21, 329, 369, 2043, 370, 130, 292, 1496, 373, 1258, 805, 737, 131, 227, 738, 1186, 526, 297, 2419, 527, 151, 814, 298, 179, 603, 181, 258, 607, 2588, 907, 381, 1057, 260, 1591, 2358, 912, 990, 71, 269, 855, 1209, 271, 119, 2919, 2015, 2305, 1156, 2844, 2248, 1782, 3120, 3169, 62, 713, 2790]}}, "Orc1 removal from chromatin": {"direction": "up", "overlap": {"value": 34, "mean": 14.364077669902912, "std": 8.355189705990739, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 18}}, "setsize": {"value": 52, "mean": 49.74757281553398, "std": 2.308567607855075, "bin": {"bin_50": 65, "bin_100": 65, "bin_250": 65, "bin_500": 65}}, "score": {"value": 4.686916536838483, "mean": 0.6917566411101944, "std": 1.2721915859610031, "bin": {"bin_50": 3.2822265625, "bin_100": 5.057963709677419, "bin_250": 7.557677616501146, "bin_500": 7.700265957446809}}, "pval": {"value": 2.773520080490144e-06, "mean": 0.5422658696614091, "std": 0.3803308697876651, "bin": {"bin_50": 0.2695684389372801, "bin_100": 0.0251363642152908, "bin_250": 3.3403257767839543e-06, "bin_500": 1.0845890202300055e-09}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 26, 151, 514, 515, 651, 181, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 603, 814, 381, 458, 570, 568, 731, 224, 225, 227, 115, 590, 589], "full": [1088, 568, 26, 1024, 1629, 958, 1796, 570, 651, 797, 1040, 589, 1489, 590, 115, 407, 224, 514, 515, 458, 225, 731, 1407, 1252, 370, 373, 1258, 227, 738, 1186, 526, 297, 527, 151, 814, 298, 179, 603, 181, 258, 907, 381, 1057, 1591, 2358, 912, 71, 855, 1209, 1156, 62, 713]}}, "Cellular response to starvation": {"direction": "up", "overlap": {"value": 57, "mean": 41.6747572815534, "std": 14.200404878998892, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 26}}, "setsize": {"value": 90, "mean": 88.34466019417475, "std": 2.6553930524825846, "bin": {"bin_50": 139, "bin_100": 139, "bin_250": 139, "bin_500": 139}}, "score": {"value": 4.625366931839361, "mean": -1.0303047421198284, "std": 2.028552953689577, "bin": {"bin_50": 1.511020531400966, "bin_100": 2.2888327205882355, "bin_250": 3.1981629861246823, "bin_500": 4.672453877306134}}, "pval": {"value": 3.739358158227901e-06, "mean": 0.3510932752390905, "std": 0.3779284314527495, "bin": {"bin_50": 0.4904368630106878, "bin_100": 0.1526361156980193, "bin_250": 0.0020669790309363, "bin_500": 2.609562208705709e-09}}, "signature_idxs": {"edge": [974, 371, 681, 680, 133, 565, 513, 150, 679, 153, 905, 903, 529, 300, 902, 861, 901, 48, 405, 180, 899, 894, 656, 416, 412, 299, 293, 803, 670, 342, 799, 604, 818, 202, 605, 86, 817, 581, 84, 815, 813, 965, 816, 379, 456, 457, 464, 602, 468, 104, 471, 226, 469, 470, 982, 721, 601], "full": [581, 3091, 84, 965, 721, 656, 405, 2412, 1038, 456, 1561, 1563, 1961, 513, 1247, 457, 799, 1042, 973, 1494, 371, 1255, 1256, 2806, 1409, 1654, 670, 2342, 86, 974, 894, 226, 464, 803, 293, 2701, 150, 1571, 412, 202, 468, 899, 1189, 813, 1503, 1578, 469, 104, 982, 601, 470, 901, 471, 815, 816, 679, 902, 299, 817, 818, 416, 1123, 180, 48, 903, 602, 1420, 680, 681, 300, 1124, 133, 604, 605, 2810, 529, 379, 1050, 153, 1666, 905, 1128, 2710, 3105, 342, 1446, 2079, 861, 2955, 565]}}, "Transcriptional regulation by runx2": {"direction": "up", "overlap": {"value": 38, "mean": 16.021844660194176, "std": 8.286848189022676, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 11, "bin_500": 20}}, "setsize": {"value": 56, "mean": 51.64320388349515, "std": 3.0091087328640205, "bin": {"bin_50": 100, "bin_100": 100, "bin_250": 100, "bin_500": 100}}, "score": {"value": 4.623440864051999, "mean": 0.5147340657969439, "std": 1.321202711135219, "bin": {"bin_50": 2.114478114478114, "bin_100": 3.2216494845360826, "bin_250": 5.141468733703125, "bin_500": 5.0303347280334725}}, "pval": {"value": 3.7742637541970936e-06, "mean": 0.5490234274922848, "std": 0.3758826947187164, "bin": {"bin_50": 0.3837477700868037, "bin_100": 0.0732279741082547, "bin_250": 2.961562075578077e-05, "bin_500": 5.713070455458839e-08}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 259, 26, 151, 511, 514, 515, 516, 651, 521, 181, 863, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 201, 603, 814, 381, 458, 568, 224, 225, 726, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 958, 651, 1955, 511, 1238, 3061, 1241, 201, 726, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 516, 370, 521, 373, 1258, 227, 738, 1259, 526, 297, 527, 151, 814, 298, 179, 603, 181, 258, 907, 381, 1273, 1057, 259, 2358, 912, 71, 2778, 855, 1209, 62, 863, 713]}}, "Clec7a dectin 1 signaling": {"direction": "up", "overlap": {"value": 41, "mean": 14.883495145631068, "std": 8.39359553685929, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 12, "bin_500": 20}}, "setsize": {"value": 50, "mean": 47.679611650485434, "std": 3.2641435107686965, "bin": {"bin_50": 85, "bin_100": 85, "bin_250": 85, "bin_500": 85}}, "score": {"value": 4.590391996555505, "mean": 0.3802624296591366, "std": 1.369019650621671, "bin": {"bin_50": 2.4957837301587302, "bin_100": 3.816692073170732, "bin_250": 6.878337589969816, "bin_500": 6.200836820083682}}, "pval": {"value": 4.424143380310497e-06, "mean": 0.5314258409805565, "std": 0.3735312556615013, "bin": {"bin_50": 0.3371313972628795, "bin_100": 0.049541392930243, "bin_250": 8.964213844581752e-07, "bin_500": 2.9684396842626283e-09}}, "signature_idxs": {"edge": [748, 590, 370, 373, 738, 678, 713, 258, 26, 1057, 151, 514, 515, 651, 181, 1024, 907, 407, 526, 1040, 527, 62, 855, 179, 297, 797, 298, 343, 71, 201, 814, 959, 958, 458, 103, 568, 224, 225, 227, 115, 912], "full": [1088, 568, 26, 1024, 1629, 1225, 958, 959, 651, 201, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 678, 103, 151, 814, 298, 179, 181, 1974, 258, 748, 907, 1131, 1057, 2358, 912, 1196, 343, 71, 855, 1209, 62, 713]}}, "Nonsense mediated decay nmd": {"direction": "up", "overlap": {"value": 53, "mean": 42.101941747572816, "std": 15.03730946151162, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 24}}, "setsize": {"value": 86, "mean": 85.76941747572816, "std": 2.536670214507658, "bin": {"bin_50": 110, "bin_100": 110, "bin_250": 110, "bin_500": 110}}, "score": {"value": 4.558967524940328, "mean": -1.1457400111181046, "std": 2.1258465434199816, "bin": {"bin_50": 1.918577981651376, "bin_100": 2.917640186915888, "bin_250": 4.137815126050421, "bin_500": 5.659110980276715}}, "pval": {"value": 5.140571880835054e-06, "mean": 0.3421409039593034, "std": 0.3829653082446096, "bin": {"bin_50": 0.4130249240673272, "bin_100": 0.0913401304990165, "bin_250": 0.0003359769202791, "bin_500": 4.0941566300645046e-10}}, "signature_idxs": {"edge": [974, 681, 680, 133, 565, 513, 149, 150, 679, 153, 528, 905, 903, 529, 300, 902, 901, 405, 48, 899, 180, 894, 656, 416, 412, 299, 293, 803, 799, 665, 604, 818, 605, 86, 817, 84, 815, 813, 816, 379, 456, 457, 464, 602, 468, 104, 471, 226, 469, 470, 982, 721, 601], "full": [3091, 84, 721, 656, 1559, 149, 405, 2412, 1038, 456, 513, 1247, 457, 799, 1042, 665, 973, 1494, 1255, 2415, 2806, 1409, 1654, 86, 974, 894, 226, 464, 803, 293, 2701, 150, 1571, 412, 1964, 468, 899, 1189, 813, 1578, 469, 104, 982, 601, 470, 901, 471, 815, 816, 679, 902, 299, 1350, 817, 818, 416, 1123, 180, 48, 903, 602, 1420, 680, 681, 300, 1124, 133, 604, 605, 528, 2810, 529, 379, 1050, 153, 1666, 905, 1268, 1128, 2355, 3095, 1517, 1607, 2093, 565, 1943]}}, "C type lectin receptors clrs": {"direction": "up", "overlap": {"value": 42, "mean": 15.640776699029129, "std": 8.889127611188893, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 13, "bin_500": 21}}, "setsize": {"value": 55, "mean": 51.34708737864078, "std": 4.137023959900662, "bin": {"bin_50": 100, "bin_100": 100, "bin_250": 100, "bin_500": 100}}, "score": {"value": 4.542635108342664, "mean": 0.3190386727488686, "std": 1.350649221433646, "bin": {"bin_50": 2.114478114478114, "bin_100": 3.2216494845360826, "bin_250": 6.270139398385913, "bin_500": 5.360480853435236}}, "pval": {"value": 5.555536734425104e-06, "mean": 0.5456940089786598, "std": 0.371203640545422, "bin": {"bin_50": 0.3837477700868037, "bin_100": 0.0732279741082547, "bin_250": 8.263831209352142e-07, "bin_500": 1.0672471884432022e-08}}, "signature_idxs": {"edge": [748, 370, 373, 912, 738, 678, 713, 258, 26, 1057, 151, 514, 515, 651, 181, 1024, 907, 407, 526, 527, 62, 855, 179, 297, 797, 298, 343, 71, 201, 814, 959, 958, 458, 103, 986, 219, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 1225, 958, 959, 651, 1726, 219, 201, 1403, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 678, 103, 151, 814, 298, 179, 181, 1974, 258, 748, 986, 907, 1131, 1057, 2358, 912, 1196, 3129, 343, 71, 855, 1209, 62, 713]}}, "Synthesis of wybutosine at g37 of trna phe": {"direction": "up", "overlap": {"value": 0, "mean": 0.46, "std": 0.5553377350765928, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.1, "std": 0.3, "bin": {"bin_50": 6, "bin_100": 6, "bin_250": 6, "bin_500": 6}}, "score": {"value": 4.541544528562504, "mean": 0.3987740190618498, "std": 1.8240097286044312, "bin": {"bin_50": 42.25833333333333, "bin_100": 20.59591836734694, "bin_250": 8.051012145748988, "bin_500": 3.900603621730382}}, "pval": {"value": 5.584358754529006e-06, "mean": 0.2747509178980614, "std": 0.2998006386214638, "bin": {"bin_50": 0.028497516818446, "bin_100": 0.0568757538574934, "bin_250": 0.1373795195898598, "bin_500": 0.2595746201812825}}, "signature_idxs": {"edge": [], "full": [20]}}, "Signaling by the b cell receptor bcr": {"direction": "up", "overlap": {"value": 39, "mean": 14.0873786407767, "std": 7.669263829832862, "bin": {"bin_50": 3, "bin_100": 5, "bin_250": 13, "bin_500": 20}}, "setsize": {"value": 49, "mean": 45.66747572815534, "std": 3.2521255837555954, "bin": {"bin_50": 91, "bin_100": 91, "bin_250": 91, "bin_500": 91}}, "score": {"value": 4.538625704276514, "mean": 0.5600618981864348, "std": 1.3165243686049508, "bin": {"bin_50": 7.454792490118577, "bin_100": 6.191860465116279, "bin_250": 7.0, "bin_500": 5.673286581413165}}, "pval": {"value": 5.662203829137624e-06, "mean": 0.5194725240755018, "std": 0.3716278052198193, "bin": {"bin_50": 0.0094231818265578, "bin_100": 0.0018751862862679, "bin_250": 2.706366172303128e-07, "bin_500": 1.0504025209620209e-08}}, "signature_idxs": {"edge": [748, 370, 373, 912, 738, 258, 713, 26, 1057, 31, 151, 514, 515, 34, 651, 181, 1024, 907, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 814, 959, 958, 458, 219, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 1225, 958, 959, 651, 1726, 2409, 219, 34, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 31, 1266, 181, 258, 748, 907, 1057, 2358, 912, 71, 855, 1209, 62, 713]}}, "Degradation of beta catenin by the destruction complex": {"direction": "up", "overlap": {"value": 39, "mean": 14.8252427184466, "std": 8.029589918636947, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 17}}, "setsize": {"value": 51, "mean": 48.63834951456311, "std": 2.025992551710678, "bin": {"bin_50": 77, "bin_100": 77, "bin_250": 77, "bin_500": 77}}, "score": {"value": 4.536486725344862, "mean": 0.4830095996380346, "std": 1.2813542829769398, "bin": {"bin_50": 2.760690789473684, "bin_100": 4.2326858108108105, "bin_250": 6.196538316819265, "bin_500": 5.677269577269577}}, "pval": {"value": 5.719908799939333e-06, "mean": 0.5534777326316677, "std": 0.3757731368449524, "bin": {"bin_50": 0.310874529382391, "bin_100": 0.0387578340752644, "bin_250": 1.584797137057646e-05, "bin_500": 1.2555708447636384e-07}}, "signature_idxs": {"edge": [590, 1062, 370, 373, 738, 908, 258, 713, 26, 1057, 151, 514, 515, 651, 909, 181, 1024, 907, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 665, 603, 814, 958, 458, 568, 224, 225, 227, 115, 912], "full": [1088, 568, 26, 1024, 1629, 958, 651, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 665, 1566, 2524, 370, 373, 1258, 227, 738, 1259, 526, 297, 1418, 527, 151, 814, 298, 179, 603, 181, 1127, 258, 907, 908, 909, 1057, 1592, 2358, 912, 1062, 71, 855, 1209, 62, 713]}}, "Synthesis of pi": {"direction": "dw", "overlap": {"value": 1, "mean": 0.8140703517587939, "std": 0.5978210141002709, "bin": {}}, "setsize": {"value": 1, "mean": 1.542713567839196, "std": 0.4981722103072856, "bin": {}}, "score": {"value": -4.532176218707694, "mean": -0.4878710126392968, "std": 1.6020354896392677, "bin": {}}, "pval": {"value": 5.8379116580908885e-06, "mean": 0.3497253296072469, "std": 0.328268621407454, "bin": {}}, "signature_idxs": {"edge": [3194], "full": [3194]}}, "Regulation of runx3 expression and activity": {"direction": "up", "overlap": {"value": 31, "mean": 11.46359223300971, "std": 6.642474003130895, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 18}}, "setsize": {"value": 40, "mean": 36.730582524271846, "std": 1.4202887203012589, "bin": {"bin_50": 52, "bin_100": 52, "bin_250": 52, "bin_500": 52}}, "score": {"value": 4.529062070006709, "mean": 0.6696914114866416, "std": 1.288769965462232, "bin": {"bin_50": 4.124183006535947, "bin_100": 6.408163265306122, "bin_250": 9.90996398559424, "bin_500": 10.658823529411764}}, "pval": {"value": 5.924609414398319e-06, "mean": 0.4949350431730664, "std": 0.3632605735082652, "bin": {"bin_50": 0.2220822570468345, "bin_100": 0.0139156518076104, "bin_250": 3.896719595610786e-07, "bin_500": 1.6811943862141228e-11}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 259, 26, 151, 514, 515, 651, 407, 527, 526, 62, 855, 179, 297, 797, 298, 802, 71, 201, 814, 458, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 958, 651, 201, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 802, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 258, 907, 259, 912, 71, 855, 1209, 62, 713]}}, "Cyclin a cdk2 associated events at s phase entry": {"direction": "up", "overlap": {"value": 37, "mean": 13.196601941747574, "std": 7.221373891468615, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 18}}, "setsize": {"value": 44, "mean": 42.85679611650485, "std": 2.098630488986879, "bin": {"bin_50": 79, "bin_100": 79, "bin_250": 79, "bin_500": 79}}, "score": {"value": 4.513770603934913, "mean": 0.6136168472607347, "std": 1.3159566032429193, "bin": {"bin_50": 2.689369658119658, "bin_100": 4.120476973684211, "bin_250": 6.015710632078918, "bin_500": 5.92438524590164}}, "pval": {"value": 6.368510022669582e-06, "mean": 0.5150313285959647, "std": 0.3694066609952225, "bin": {"bin_50": 0.3175327074700926, "bin_100": 0.0413282647695778, "bin_250": 1.994495517635176e-05, "bin_500": 3.1670740297736504e-08}}, "signature_idxs": {"edge": [590, 370, 373, 738, 258, 713, 26, 1057, 151, 514, 515, 651, 181, 1024, 907, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 821, 814, 381, 958, 458, 568, 224, 225, 227, 115, 912, 589], "full": [1088, 568, 26, 1024, 1629, 958, 651, 1955, 1241, 797, 1040, 589, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 181, 258, 821, 907, 381, 1057, 912, 71, 855, 1209, 62, 713]}}, "Interleukin 1 signaling": {"direction": "up", "overlap": {"value": 33, "mean": 13.79368932038835, "std": 7.891168652335007, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 11, "bin_500": 20}}, "setsize": {"value": 47, "mean": 46.30582524271845, "std": 2.7901813019255988, "bin": {"bin_50": 82, "bin_100": 82, "bin_250": 82, "bin_500": 82}}, "score": {"value": 4.509125834041746, "mean": 0.5021606336105483, "std": 1.3195993763744758, "bin": {"bin_50": 2.588991769547325, "bin_100": 3.9628164556962022, "bin_250": 6.456706483627503, "bin_500": 6.502901876096639}}, "pval": {"value": 6.509529203890807e-06, "mean": 0.5332552544880472, "std": 0.3779352216468381, "bin": {"bin_50": 0.3274019772455256, "bin_100": 0.0453414776018772, "bin_250": 4.305195554458758e-06, "bin_500": 1.505587266235451e-09}}, "signature_idxs": {"edge": [370, 373, 738, 251, 258, 713, 26, 304, 151, 514, 515, 651, 181, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 603, 814, 458, 103, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 1225, 958, 651, 251, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 103, 151, 814, 298, 179, 603, 181, 304, 258, 907, 1131, 1057, 2358, 912, 1196, 71, 855, 1209, 62, 713]}}, "Signaling by hedgehog": {"direction": "up", "overlap": {"value": 38, "mean": 16.28640776699029, "std": 8.199307909979849, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 13, "bin_500": 22}}, "setsize": {"value": 59, "mean": 57.470873786407765, "std": 3.6419383260123857, "bin": {"bin_50": 122, "bin_100": 122, "bin_250": 122, "bin_500": 122}}, "score": {"value": 4.498839856435595, "mean": 0.6189752673658386, "std": 1.1996921179618314, "bin": {"bin_50": 1.7262396694214877, "bin_100": 2.6202731092436973, "bin_250": 4.993441342963108, "bin_500": 4.436050420168067}}, "pval": {"value": 6.832530087264033e-06, "mean": 0.5630638540633491, "std": 0.3729858641615031, "bin": {"bin_50": 0.4463627535095094, "bin_100": 0.1152579533053658, "bin_250": 7.940156790201186e-06, "bin_500": 8.814633006188767e-08}}, "signature_idxs": {"edge": [730, 143, 370, 373, 738, 258, 713, 26, 151, 514, 515, 651, 181, 302, 401, 407, 526, 527, 62, 676, 855, 179, 297, 797, 298, 71, 236, 603, 770, 814, 458, 568, 220, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 958, 651, 401, 2993, 220, 1483, 1403, 797, 1040, 3166, 590, 115, 407, 224, 514, 515, 458, 225, 730, 1493, 370, 373, 1258, 227, 738, 1259, 526, 297, 676, 527, 151, 814, 298, 179, 603, 181, 302, 258, 907, 1057, 1191, 236, 2358, 912, 2364, 1995, 71, 770, 855, 1209, 143, 62, 713, 1320]}}, "Scf skp2 mediated degradation of p27 p21": {"direction": "up", "overlap": {"value": 36, "mean": 12.78883495145631, "std": 7.12520288261254, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 18}}, "setsize": {"value": 42, "mean": 40.70873786407767, "std": 1.2647657441579598, "bin": {"bin_50": 54, "bin_100": 54, "bin_250": 54, "bin_500": 54}}, "score": {"value": 4.492233128453622, "mean": 0.5921499036968256, "std": 1.3047123749289669, "bin": {"bin_50": 3.967767295597484, "bin_100": 6.1556372549019605, "bin_250": 9.457601222307105, "bin_500": 10.064583333333331}}, "pval": {"value": 7.048020945088496e-06, "mean": 0.5162943652980111, "std": 0.3686628673319737, "bin": {"bin_50": 0.2295798469686227, "bin_100": 0.0154029461510805, "bin_250": 5.647844429312538e-07, "bin_500": 3.4856423783748357e-11}}, "signature_idxs": {"edge": [590, 370, 373, 738, 258, 713, 26, 1057, 151, 514, 515, 651, 181, 1024, 907, 407, 527, 526, 62, 855, 179, 297, 797, 298, 71, 814, 381, 958, 458, 568, 224, 225, 227, 115, 912, 589], "full": [1088, 568, 26, 1024, 1629, 958, 651, 1241, 797, 1040, 589, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 181, 258, 907, 381, 1057, 912, 71, 855, 1209, 62, 713]}}, "Tfap2 ap 2 family regulates transcription of growth factors and their receptors": {"direction": "dw", "overlap": {"value": 1, "mean": 0.6620879120879121, "std": 0.5775964150209826, "bin": {}}, "setsize": {"value": 1, "mean": 1.2252747252747254, "std": 0.4432877681654935, "bin": {}}, "score": {"value": -4.491053777687475, "mean": -0.3891588308190017, "std": 1.6442001135724735, "bin": {}}, "pval": {"value": 7.087165211139279e-06, "mean": 0.3456257043794477, "std": 0.3159594029704098, "bin": {}}, "signature_idxs": {"edge": [3168], "full": [3168]}}, "Fc epsilon receptor fceri signaling": {"direction": "up", "overlap": {"value": 41, "mean": 16.155339805825243, "std": 8.909749521452186, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 12, "bin_500": 19}}, "setsize": {"value": 54, "mean": 52.529126213592235, "std": 4.003836293074435, "bin": {"bin_50": 108, "bin_100": 108, "bin_250": 108, "bin_500": 108}}, "score": {"value": 4.462561353659202, "mean": 0.3577248991718689, "std": 1.3201566724870089, "bin": {"bin_50": 1.954828660436137, "bin_100": 2.973809523809524, "bin_250": 5.218220338983051, "bin_500": 4.282587788229223}}, "pval": {"value": 8.09857294714611e-06, "mean": 0.5588293080975716, "std": 0.369825714615891, "bin": {"bin_50": 0.4072806445693771, "bin_100": 0.087578872676897, "bin_250": 1.158307428973248e-05, "bin_500": 9.952905187294492e-07}}, "signature_idxs": {"edge": [748, 370, 373, 912, 738, 258, 713, 26, 1057, 151, 514, 515, 516, 651, 181, 1024, 904, 907, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 814, 959, 958, 458, 103, 986, 219, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 1225, 958, 959, 651, 1726, 219, 797, 1485, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 516, 370, 373, 1258, 227, 738, 526, 297, 527, 103, 151, 814, 298, 179, 1266, 904, 181, 258, 748, 986, 907, 1131, 1057, 2358, 912, 1196, 3129, 71, 855, 1209, 62, 713]}}, "The role of gtse1 in g2 m progression after g2 checkpoint": {"direction": "up", "overlap": {"value": 37, "mean": 14.79611650485437, "std": 7.820323564061835, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 11, "bin_500": 20}}, "setsize": {"value": 50, "mean": 48.84466019417476, "std": 1.8499922936255029, "bin": {"bin_50": 67, "bin_100": 67, "bin_250": 67, "bin_500": 67}}, "score": {"value": 4.461800555869139, "mean": 0.6226477470486884, "std": 1.3076695437390702, "bin": {"bin_50": 3.1821338383838382, "bin_100": 4.89892578125, "bin_250": 8.198613622664256, "bin_500": 8.591649603845811}}, "pval": {"value": 8.127385252132413e-06, "mean": 0.5168095546238419, "std": 0.3722860732713196, "bin": {"bin_50": 0.2766173679843171, "bin_100": 0.0271898890726632, "bin_250": 5.450864364298083e-07, "bin_500": 2.7898241426443718e-11}}, "signature_idxs": {"edge": [143, 370, 373, 912, 738, 258, 538, 713, 26, 878, 151, 511, 514, 515, 651, 302, 401, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 236, 814, 458, 568, 224, 225, 726, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 958, 651, 2402, 401, 3022, 511, 1237, 878, 726, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 1818, 297, 527, 151, 814, 298, 179, 302, 258, 907, 236, 2358, 912, 538, 71, 855, 1209, 143, 62, 713]}}, "Cellular response to hypoxia": {"direction": "up", "overlap": {"value": 31, "mean": 12.067961165048544, "std": 6.981963081004602, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 17}}, "setsize": {"value": 43, "mean": 40.00485436893204, "std": 1.736242938617286, "bin": {"bin_50": 59, "bin_100": 59, "bin_250": 59, "bin_500": 59}}, "score": {"value": 4.449745083920603, "mean": 0.522970313217548, "std": 1.3015320227429066, "bin": {"bin_50": 3.623922413793104, "bin_100": 5.603236607142857, "bin_250": 7.454560669456067, "bin_500": 8.125532125532125}}, "pval": {"value": 8.597227183937406e-06, "mean": 0.5163863933875538, "std": 0.3618367398400983, "bin": {"bin_50": 0.2480154974279715, "bin_100": 0.0195000915431133, "bin_250": 1.120343948585762e-05, "bin_500": 1.6107763180436515e-09}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 26, 832, 151, 514, 515, 651, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 477, 603, 814, 458, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 958, 651, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 603, 258, 907, 1276, 2358, 912, 832, 477, 71, 855, 1209, 1620, 62, 713]}}, "Pexophagy": {"direction": "up", "overlap": {"value": 0, "mean": 0.5465116279069767, "std": 0.6408021271374351, "bin": {"bin_50": 0, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.6395348837209305, "std": 0.6805058087627689, "bin": {"bin_50": 9, "bin_100": 9, "bin_250": 9, "bin_500": 9}}, "score": {"value": 4.430113789899704, "mean": 0.7512790228278386, "std": 1.4487933985882169, "bin": {"bin_50": 0.0, "bin_100": 12.868622448979592, "bin_250": 5.030364372469635, "bin_500": 2.437122736418511}}, "pval": {"value": 9.418337850508609e-06, "mean": 0.3399067924311594, "std": 0.3098057284899315, "bin": {"bin_50": 1.0, "bin_100": 0.0841007109914387, "bin_250": 0.1988473022417859, "bin_500": 0.3629223192764827}}, "signature_idxs": {"edge": [], "full": [87]}}, "N glycan trimming and elongation in the cis golgi": {"direction": "up", "overlap": {"value": 0, "mean": 0.547244094488189, "std": 0.6667971124988309, "bin": {"bin_50": 0, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.4606299212598426, "std": 0.6673083174970781, "bin": {"bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 4.427040855477475, "mean": 0.7089622202775997, "std": 1.8589944520404704, "bin": {"bin_50": 0.0, "bin_100": 34.333333333333336, "bin_250": 13.421052631578949, "bin_500": 6.502347417840376}}, "pval": {"value": 9.553464288769575e-06, "mean": 0.2822931901772597, "std": 0.3222709048987781, "bin": {"bin_50": 1.0, "bin_100": 0.0382822948212792, "bin_250": 0.0938138368307335, "bin_500": 0.1815422125939431}}, "signature_idxs": {"edge": [], "full": [85]}}, "Degradation of gli1 by the proteasome": {"direction": "up", "overlap": {"value": 36, "mean": 12.514563106796116, "std": 7.125251251124314, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 17}}, "setsize": {"value": 43, "mean": 40.61407766990291, "std": 1.5545410691631658, "bin": {"bin_50": 53, "bin_100": 53, "bin_250": 53, "bin_500": 53}}, "score": {"value": 4.425693011846819, "mean": 0.5405675752115602, "std": 1.272200728765061, "bin": {"bin_50": 4.044471153846154, "bin_100": 6.279375, "bin_250": 9.678522571819425, "bin_500": 9.485677985677986}}, "pval": {"value": 9.61331566950996e-06, "mean": 0.5324758124461996, "std": 0.3678115987415289, "bin": {"bin_50": 0.225839943305071, "bin_100": 0.0146485330026984, "bin_250": 4.701360390161145e-07, "bin_500": 2.46454873445979e-10}}, "signature_idxs": {"edge": [590, 370, 373, 738, 258, 713, 26, 1057, 151, 514, 515, 651, 181, 1024, 907, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 770, 603, 814, 958, 458, 568, 224, 225, 227, 115, 912], "full": [1088, 568, 26, 1024, 1629, 958, 651, 1403, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 603, 181, 258, 907, 1057, 2358, 912, 71, 770, 855, 1209, 62, 713]}}, "Diseases of signal transduction by growth factor receptors and second messengers": {"direction": "up", "overlap": {"value": 52, "mean": 38.23543689320388, "std": 15.041864122024071, "bin": {"bin_50": 4, "bin_100": 7, "bin_250": 19, "bin_500": 35}}, "setsize": {"value": 149, "mean": 143.25485436893203, "std": 11.50835917079556, "bin": {"bin_50": 333, "bin_100": 333, "bin_250": 333, "bin_500": 333}}, "score": {"value": 4.42466151106445, "mean": 0.0760803095091799, "std": 0.9951358349988204, "bin": {"bin_50": 2.6526173590003377, "bin_100": 2.2805081355028007, "bin_250": 2.545629015659333, "bin_500": 2.384507225999102}}, "pval": {"value": 9.65936153352054e-06, "mean": 0.6705657643193705, "std": 0.3506422537450402, "bin": {"bin_50": 0.0751636281055282, "bin_100": 0.0429961144842739, "bin_250": 0.0004911386673349, "bin_500": 1.454115633831355e-05}}, "signature_idxs": {"edge": [587, 367, 370, 13, 373, 12, 249, 258, 713, 26, 262, 304, 31, 151, 514, 515, 516, 651, 659, 521, 181, 527, 526, 407, 409, 62, 676, 179, 416, 297, 53, 298, 667, 71, 494, 340, 201, 603, 475, 597, 458, 568, 219, 220, 224, 122, 225, 227, 115, 116, 549, 590], "full": [787, 1088, 568, 26, 2107, 1024, 1629, 1225, 1474, 958, 249, 1870, 1798, 651, 1875, 1639, 1172, 1726, 2960, 3176, 1034, 1237, 1238, 219, 722, 220, 1100, 2639, 201, 659, 797, 1959, 1485, 2038, 2641, 1040, 884, 587, 2698, 590, 115, 407, 224, 1105, 367, 2040, 514, 515, 458, 225, 516, 53, 665, 1566, 2338, 667, 2700, 1493, 1251, 2524, 1732, 1568, 370, 1179, 2045, 409, 597, 521, 2342, 373, 1257, 1258, 1046, 227, 738, 2702, 2808, 1259, 1114, 2418, 526, 1964, 297, 676, 1418, 527, 151, 2207, 814, 298, 179, 1663, 416, 2904, 603, 31, 1266, 904, 181, 2583, 1972, 1824, 2269, 304, 116, 258, 2703, 475, 2355, 907, 908, 1273, 909, 1430, 1275, 2060, 1057, 1431, 1592, 1831, 2358, 912, 1062, 1063, 262, 2143, 2148, 1756, 1841, 340, 1848, 71, 1290, 1695, 12, 1455, 855, 1209, 549, 494, 858, 13, 2980, 2788, 2922, 62, 713, 122, 1319]}}, "Tnfr2 non canonical nf kb pathway": {"direction": "up", "overlap": {"value": 36, "mean": 12.75242718446602, "std": 7.499311873418453, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 18}}, "setsize": {"value": 44, "mean": 41.54126213592233, "std": 1.6207832096977548, "bin": {"bin_50": 58, "bin_100": 58, "bin_250": 58, "bin_500": 58}}, "score": {"value": 4.415752777869133, "mean": 0.4835600067503021, "std": 1.329411623900184, "bin": {"bin_50": 3.687865497076024, "bin_100": 5.7056818181818185, "bin_250": 8.665966386554622, "bin_500": 9.054375}}, "pval": {"value": 1.0065907483980396e-05, "mean": 0.5236768662797463, "std": 0.3708129323396963, "bin": {"bin_50": 0.2443632781182481, "bin_100": 0.0186371594327644, "bin_250": 1.1306042612128208e-06, "bin_500": 1.3482575775431775e-10}}, "signature_idxs": {"edge": [590, 370, 373, 738, 678, 713, 258, 26, 1057, 151, 514, 515, 651, 181, 1024, 907, 407, 526, 527, 62, 855, 179, 297, 797, 298, 343, 71, 814, 958, 458, 568, 224, 225, 227, 115, 912], "full": [1088, 568, 26, 1024, 1629, 1225, 958, 651, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 678, 151, 814, 298, 179, 181, 258, 1747, 907, 1057, 2358, 912, 343, 71, 855, 1209, 62, 713]}}, "Dectin 1 mediated noncanonical nf kb signaling": {"direction": "up", "overlap": {"value": 36, "mean": 12.844660194174756, "std": 7.477483717709433, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 18}}, "setsize": {"value": 43, "mean": 41.46116504854369, "std": 1.5951828582954857, "bin": {"bin_50": 53, "bin_100": 53, "bin_250": 53, "bin_500": 53}}, "score": {"value": 4.403077000843676, "mean": 0.4840649810639716, "std": 1.3371619060105078, "bin": {"bin_50": 4.044471153846154, "bin_100": 6.279375, "bin_250": 9.678522571819425, "bin_500": 10.353214285714284}}, "pval": {"value": 1.0672626447494338e-05, "mean": 0.5219757714388732, "std": 0.3706757674751831, "bin": {"bin_50": 0.225839943305071, "bin_100": 0.0146485330026984, "bin_250": 4.701360390161145e-07, "bin_500": 2.432249144149152e-11}}, "signature_idxs": {"edge": [590, 370, 373, 738, 678, 713, 258, 26, 1057, 151, 514, 515, 651, 181, 1024, 907, 407, 526, 527, 62, 855, 179, 297, 797, 298, 343, 71, 814, 958, 458, 568, 224, 225, 227, 115, 912], "full": [1088, 568, 26, 1024, 1629, 1225, 958, 651, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 678, 151, 814, 298, 179, 181, 258, 907, 1057, 2358, 912, 343, 71, 855, 1209, 62, 713]}}, "S phase": {"direction": "up", "overlap": {"value": 52, "mean": 25.58252427184466, "std": 12.311904628033766, "bin": {"bin_50": 2, "bin_100": 4, "bin_250": 14, "bin_500": 29}}, "setsize": {"value": 97, "mean": 94.497572815534, "std": 6.6662819095148595, "bin": {"bin_50": 158, "bin_100": 158, "bin_250": 158, "bin_500": 158}}, "score": {"value": 4.395421700809822, "mean": 0.3936025929765626, "std": 1.1799446716032989, "bin": {"bin_50": 2.7253136933988, "bin_100": 2.718523581681477, "bin_250": 4.073361823361823, "bin_500": 4.586717574916117}}, "pval": {"value": 1.105579110727284e-05, "mean": 0.6471527110395977, "std": 0.3778079902664983, "bin": {"bin_50": 0.1757629685498992, "bin_100": 0.0675797720929864, "bin_250": 2.985734600302532e-05, "bin_500": 4.949765947670492e-10}}, "signature_idxs": {"edge": [369, 370, 373, 738, 737, 130, 131, 252, 21, 258, 713, 260, 26, 151, 514, 515, 651, 181, 527, 526, 407, 62, 855, 179, 292, 297, 797, 298, 805, 607, 71, 329, 821, 603, 814, 381, 458, 570, 568, 731, 729, 225, 224, 119, 227, 921, 115, 269, 271, 591, 590, 589], "full": [1088, 568, 26, 1024, 1629, 958, 1796, 570, 1946, 651, 1955, 1482, 1241, 252, 1242, 797, 1104, 1040, 589, 1489, 590, 115, 407, 224, 591, 514, 515, 458, 225, 729, 2996, 731, 1407, 1252, 21, 329, 369, 2043, 370, 130, 292, 1496, 373, 1258, 805, 737, 131, 227, 738, 1186, 1259, 526, 297, 2419, 527, 151, 814, 298, 179, 603, 181, 258, 607, 821, 2588, 907, 381, 1057, 260, 1591, 2707, 2358, 912, 990, 1907, 921, 2912, 71, 269, 855, 1209, 271, 119, 2919, 2015, 2305, 2734, 1156, 2844, 2248, 1782, 3120, 3169, 62, 713, 2562, 2790]}}, "Scavenging by class b receptors": {"direction": "dw", "overlap": {"value": 1, "mean": 0.145679012345679, "std": 0.366514912271715, "bin": {}}, "setsize": {"value": 1, "mean": 1.0419753086419754, "std": 0.2005327457209575, "bin": {}}, "score": {"value": -4.389709276363188, "mean": 2.082821567211886, "std": 1.8633299667806096, "bin": {}}, "pval": {"value": 1.1350230099349544e-05, "mean": 0.0465602836219474, "std": 0.1224919585458108, "bin": {}}, "signature_idxs": {"edge": [3106], "full": [3106]}}, "Sumoylation": {"direction": "dw", "overlap": {"value": 50, "mean": 27.97087378640777, "std": 10.455134206471588, "bin": {}}, "setsize": {"value": 81, "mean": 75.44902912621359, "std": 6.947432579432031, "bin": {}}, "score": {"value": -4.38602553276, "mean": -0.8502599577556972, "std": 1.023857262091053, "bin": {}}, "pval": {"value": 1.1544057652912444e-05, "mean": 0.4911906171274051, "std": 0.3427115261701629, "bin": {}}, "signature_idxs": {"edge": [2528, 2527, 2931, 2282, 3210, 2273, 2976, 3096, 2805, 2372, 3108, 2688, 3116, 2694, 2695, 2969, 2881, 2885, 2707, 3009, 2702, 2779, 2359, 2771, 2773, 3124, 2994, 2581, 2781, 2782, 2474, 2912, 2915, 2670, 2676, 2906, 3022, 2437, 2755, 2434, 2306, 2312, 2562, 3048, 3176, 2639, 2443, 3040, 3189, 3063], "full": [1165, 1946, 2688, 1556, 2931, 2116, 3022, 3176, 3124, 1099, 2994, 3040, 252, 2639, 2694, 2695, 1339, 591, 2805, 669, 3063, 802, 2474, 1109, 2755, 2702, 977, 2527, 2581, 202, 2528, 1662, 1351, 2136, 3048, 3189, 2215, 1671, 2273, 908, 909, 2906, 2707, 2359, 3096, 2282, 2969, 3009, 2434, 2230, 2771, 2912, 1759, 2231, 2437, 2073, 2773, 2915, 1695, 2372, 2079, 2976, 344, 3210, 2670, 93, 2779, 2781, 2782, 2676, 2443, 3116, 2881, 2306, 3108, 213, 945, 946, 2312, 2562, 2885]}}, "Runx1 regulates transcription of genes involved in differentiation of hscs": {"direction": "up", "overlap": {"value": 30, "mean": 11.74514563106796, "std": 6.5789160679611225, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 17}}, "setsize": {"value": 41, "mean": 40.9247572815534, "std": 1.5190277579548277, "bin": {"bin_50": 68, "bin_100": 68, "bin_250": 68, "bin_500": 68}}, "score": {"value": 4.377132567127614, "mean": 0.4838158037368226, "std": 1.1933646193238052, "bin": {"bin_50": 3.1343283582089554, "bin_100": 4.823076923076923, "bin_250": 6.311680022693426, "bin_500": 6.685377685377685}}, "pval": {"value": 1.202508410935721e-05, "mean": 0.5501011058260618, "std": 0.3604187581137549, "bin": {"bin_50": 0.2801168002074996, "bin_100": 0.028249351231176, "bin_250": 3.631703063430464e-05, "bin_500": 1.7323342402295213e-08}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 259, 26, 151, 514, 515, 651, 407, 527, 526, 62, 855, 179, 297, 797, 298, 71, 770, 814, 458, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 958, 651, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 1351, 258, 907, 259, 2358, 912, 71, 770, 855, 1209, 62, 713]}}, "Fceri mediated nf kb activation": {"direction": "up", "overlap": {"value": 40, "mean": 13.599514563106796, "std": 7.591659945968655, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 12, "bin_500": 19}}, "setsize": {"value": 45, "mean": 43.58252427184466, "std": 2.4879291964009105, "bin": {"bin_50": 68, "bin_100": 68, "bin_250": 68, "bin_500": 68}}, "score": {"value": 4.370599348176136, "mean": 0.43538002101356, "std": 1.318650463428372, "bin": {"bin_50": 3.1343283582089554, "bin_100": 4.823076923076923, "bin_250": 8.9818401937046, "bin_500": 7.810958203740786}}, "pval": {"value": 1.2390596256128816e-05, "mean": 0.532490131621357, "std": 0.3690692407606546, "bin": {"bin_50": 0.2801168002074996, "bin_100": 0.028249351231176, "bin_250": 7.156751783587934e-08, "bin_500": 3.1337055939385987e-10}}, "signature_idxs": {"edge": [590, 370, 373, 738, 1196, 713, 258, 26, 1057, 151, 514, 515, 651, 181, 1024, 907, 407, 526, 1040, 527, 62, 855, 179, 297, 797, 298, 71, 1131, 115, 814, 958, 458, 103, 219, 568, 224, 225, 227, 1088, 912], "full": [1088, 568, 26, 1024, 1629, 1225, 958, 651, 219, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 103, 151, 814, 298, 179, 181, 258, 907, 1131, 1057, 2358, 912, 1196, 71, 855, 1209, 62, 713]}}, "Regulation of runx2 expression and activity": {"direction": "up", "overlap": {"value": 34, "mean": 13.184466019417476, "std": 7.623733474716015, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 19}}, "setsize": {"value": 47, "mean": 42.609223300970875, "std": 1.80350585730159, "bin": {"bin_50": 61, "bin_100": 61, "bin_250": 61, "bin_500": 61}}, "score": {"value": 4.351899042973503, "mean": 0.5014097272359687, "std": 1.3084091861848088, "bin": {"bin_50": 3.502430555555556, "bin_100": 5.408943965517241, "bin_250": 8.153732081067721, "bin_500": 9.11939556615966}}, "pval": {"value": 1.349634096681207e-05, "mean": 0.5334388394290158, "std": 0.3700608446837968, "bin": {"bin_50": 0.2552681350600493, "bin_100": 0.0212914346042941, "bin_250": 1.8326621852745568e-06, "bin_500": 3.8226369433188623e-11}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 259, 26, 151, 514, 515, 651, 521, 181, 863, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 603, 814, 381, 458, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 958, 651, 3061, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 521, 373, 1258, 227, 738, 1259, 526, 297, 527, 151, 814, 298, 179, 603, 181, 258, 907, 381, 1057, 259, 2358, 912, 71, 855, 1209, 62, 863, 713]}}, "Downstream signaling events of b cell receptor bcr": {"direction": "up", "overlap": {"value": 31, "mean": 13.109223300970871, "std": 7.35013455914348, "bin": {"bin_50": 2, "bin_100": 4, "bin_250": 11, "bin_500": 18}}, "setsize": {"value": 45, "mean": 42.81310679611651, "std": 2.784583610128895, "bin": {"bin_50": 71, "bin_100": 71, "bin_250": 71, "bin_500": 71}}, "score": {"value": 4.344884754362289, "mean": 0.5337893000107979, "std": 1.330630298725885, "bin": {"bin_50": 6.215232809127351, "bin_100": 6.303220738413197, "bin_250": 7.648945147679325, "bin_500": 6.824292452830188}}, "pval": {"value": 1.3934880149557571e-05, "mean": 0.5120527765027618, "std": 0.3688632335833426, "bin": {"bin_50": 0.0455724387921432, "bin_100": 0.0049422249763305, "bin_250": 9.967483917140871e-07, "bin_500": 5.147047039159139e-09}}, "signature_idxs": {"edge": [748, 370, 373, 738, 258, 713, 26, 31, 151, 514, 515, 651, 181, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 814, 458, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 1225, 958, 651, 1726, 2409, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 31, 181, 258, 748, 907, 1057, 2358, 912, 71, 855, 1209, 62, 713]}}, "Negative regulation of notch4 signaling": {"direction": "up", "overlap": {"value": 35, "mean": 12.218446601941748, "std": 7.300807876201572, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 17}}, "setsize": {"value": 42, "mean": 39.786407766990294, "std": 1.1247479582770583, "bin": {"bin_50": 49, "bin_100": 49, "bin_250": 49, "bin_500": 49}}, "score": {"value": 4.336255712408102, "mean": 0.5856668642754154, "std": 1.3003786017754655, "bin": {"bin_50": 4.383246527777778, "bin_100": 6.828125, "bin_250": 10.675500969618616, "bin_500": 10.675805613305611}}, "pval": {"value": 1.4493033119844512e-05, "mean": 0.5088435203982538, "std": 0.3684988575140048, "bin": {"bin_50": 0.2107016729382093, "bin_100": 0.0118453859760714, "bin_250": 2.158263767840273e-07, "bin_500": 5.948662443240233e-11}}, "signature_idxs": {"edge": [590, 370, 373, 738, 258, 713, 26, 1057, 151, 514, 515, 651, 181, 1024, 907, 407, 527, 526, 62, 855, 179, 297, 797, 298, 71, 603, 814, 958, 458, 568, 224, 225, 227, 115, 912], "full": [1088, 568, 26, 1024, 1629, 958, 651, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 603, 2348, 181, 258, 907, 1057, 912, 71, 855, 1209, 62, 713, 2030]}}, "Regulation of ras by gaps": {"direction": "up", "overlap": {"value": 31, "mean": 11.558252427184469, "std": 6.637200606991292, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 16}}, "setsize": {"value": 42, "mean": 38.29611650485437, "std": 1.5039380235434, "bin": {"bin_50": 57, "bin_100": 57, "bin_250": 57, "bin_500": 57}}, "score": {"value": 4.333499742545485, "mean": 0.5949031665539309, "std": 1.2829290056167597, "bin": {"bin_50": 3.754092261904762, "bin_100": 5.811921296296297, "bin_250": 7.76673640167364, "bin_500": 7.818641837870661}}, "pval": {"value": 1.467574523950077e-05, "mean": 0.5179046122727133, "std": 0.3733028763215757, "bin": {"bin_50": 0.2406936845278361, "bin_100": 0.0177960185678587, "bin_250": 8.368334725673228e-06, "bin_500": 7.455582709825399e-09}}, "signature_idxs": {"edge": [590, 370, 373, 738, 884, 713, 258, 26, 151, 514, 515, 651, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 603, 814, 458, 568, 224, 225, 227, 115, 912], "full": [1088, 568, 26, 1024, 1629, 958, 651, 1726, 797, 1040, 884, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 603, 258, 907, 1191, 2358, 912, 71, 855, 1209, 62, 713]}}, "Asymmetric localization of pcp proteins": {"direction": "up", "overlap": {"value": 29, "mean": 11.28883495145631, "std": 6.482730726459962, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 17}}, "setsize": {"value": 39, "mean": 37.80825242718446, "std": 1.1863421199640956, "bin": {"bin_50": 54, "bin_100": 54, "bin_250": 54, "bin_500": 54}}, "score": {"value": 4.333108277529643, "mean": 0.5764639774033125, "std": 1.2423982841678427, "bin": {"bin_50": 3.967767295597484, "bin_100": 6.1556372549019605, "bin_250": 9.457601222307105, "bin_500": 9.228353093217958}}, "pval": {"value": 1.4701875612921356e-05, "mean": 0.5188050170985335, "std": 0.3682278814782295, "bin": {"bin_50": 0.2295798469686227, "bin_100": 0.0154029461510805, "bin_250": 5.647844429312538e-07, "bin_500": 3.436757827628648e-10}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 26, 151, 514, 515, 651, 407, 527, 526, 182, 62, 855, 179, 297, 797, 298, 71, 814, 458, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 958, 651, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 258, 907, 182, 2358, 912, 71, 855, 1209, 62, 713]}}, "Metabolism of polyamines": {"direction": "up", "overlap": {"value": 30, "mean": 11.783980582524272, "std": 6.813709458301494, "bin": {"bin_50": 1, "bin_100": 4, "bin_250": 11, "bin_500": 18}}, "setsize": {"value": 41, "mean": 38.49271844660194, "std": 1.1915745430318114, "bin": {"bin_50": 48, "bin_100": 48, "bin_250": 48, "bin_500": 48}}, "score": {"value": 4.329780294033426, "mean": 0.5956280690899458, "std": 1.300721756016792, "bin": {"bin_50": 4.476950354609929, "bin_100": 9.620095693779904, "bin_250": 12.432546470521157, "bin_500": 12.085}}, "pval": {"value": 1.4925818077715649e-05, "mean": 0.5058612771265996, "std": 0.3709861514268986, "bin": {"bin_50": 0.2068720246529641, "bin_100": 0.0011728813459743, "bin_250": 1.4416500865542312e-08, "bin_500": 3.456729593045576e-12}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 26, 151, 514, 515, 651, 407, 527, 526, 62, 855, 179, 297, 298, 797, 71, 88, 814, 458, 568, 222, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 958, 651, 797, 222, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 88, 297, 527, 151, 814, 298, 179, 258, 907, 2358, 912, 71, 855, 1209, 2302, 62, 713]}}, "Fatty acids bound to gpr40 ffar1 regulate insulin secretion": {"direction": "dw", "overlap": {"value": 1, "mean": 0.4787878787878787, "std": 0.5115381296002229, "bin": {}}, "setsize": {"value": 1, "mean": 1.1272727272727272, "std": 0.3332782323604246, "bin": {}}, "score": {"value": -4.313697307841285, "mean": 0.2278263586118671, "std": 1.7364421116045183, "bin": {}}, "pval": {"value": 1.6054672417720184e-05, "mean": 0.324086744635414, "std": 0.3092661622243456, "bin": {}}, "signature_idxs": {"edge": [3047], "full": [3047]}}, "Tcr signaling": {"direction": "up", "overlap": {"value": 39, "mean": 14.79368932038835, "std": 8.50292119881085, "bin": {"bin_50": 2, "bin_100": 4, "bin_250": 12, "bin_500": 19}}, "setsize": {"value": 49, "mean": 47.728155339805824, "std": 3.2417009042427978, "bin": {"bin_50": 85, "bin_100": 85, "bin_250": 85, "bin_500": 85}}, "score": {"value": 4.304070372845822, "mean": 0.3776708616120087, "std": 1.3249802424411328, "bin": {"bin_50": 5.159702640348629, "bin_100": 5.206497725795972, "bin_250": 6.878337589969816, "bin_500": 5.7888277345479855}}, "pval": {"value": 1.6768835942260196e-05, "mean": 0.5474588628929388, "std": 0.3685330173213761, "bin": {"bin_50": 0.0627750690965546, "bin_100": 0.0092927708056161, "bin_250": 8.964213844581752e-07, "bin_500": 1.831050287115552e-08}}, "signature_idxs": {"edge": [370, 373, 912, 738, 258, 713, 26, 1057, 151, 514, 515, 34, 651, 181, 1024, 907, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 115, 814, 958, 458, 103, 986, 923, 568, 224, 225, 227, 597, 590], "full": [1088, 568, 26, 1024, 1629, 1225, 958, 651, 34, 797, 1485, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 597, 373, 1258, 227, 738, 526, 297, 527, 103, 151, 814, 298, 179, 181, 258, 986, 907, 1131, 1057, 2358, 912, 3129, 923, 71, 855, 1209, 62, 713]}}, "Transport of mature transcript to cytoplasm": {"direction": "dw", "overlap": {"value": 39, "mean": 22.179611650485437, "std": 9.223322687761865, "bin": {}}, "setsize": {"value": 63, "mean": 63.12378640776699, "std": 3.3978458671491603, "bin": {}}, "score": {"value": -4.294720435192036, "mean": -0.6291260216114811, "std": 1.0645020276827344, "bin": {}}, "pval": {"value": 1.749136103423865e-05, "mean": 0.5624135506222746, "std": 0.342276085943197, "bin": {}}, "signature_idxs": {"edge": [2939, 2532, 2528, 2527, 3088, 2422, 2415, 2805, 3098, 3095, 2621, 2688, 2969, 2884, 3009, 2702, 2355, 2779, 2771, 3126, 2773, 2781, 2782, 2479, 2915, 2775, 2353, 2676, 2437, 2890, 2629, 2755, 2761, 2657, 2632, 2639, 3189, 2942, 2726], "full": [2629, 2632, 2890, 2688, 359, 2639, 1565, 2805, 669, 2415, 2755, 2702, 1964, 2527, 202, 2528, 2136, 2939, 2422, 606, 1584, 2057, 2353, 2355, 2657, 3189, 2479, 155, 2761, 3126, 2532, 3095, 2942, 1908, 2969, 3009, 1688, 1068, 2771, 1759, 2231, 2437, 3098, 2073, 2773, 1998, 2915, 2775, 2079, 1528, 1001, 2779, 2781, 2782, 2676, 2726, 2306, 2884, 2621, 1623, 2312, 3088, 1943]}}, "Degradation of dvl": {"direction": "up", "overlap": {"value": 29, "mean": 11.50728155339806, "std": 6.536116642578212, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 16}}, "setsize": {"value": 40, "mean": 37.79611650485437, "std": 1.2295647923796569, "bin": {"bin_50": 50, "bin_100": 50, "bin_250": 50, "bin_500": 50}}, "score": {"value": 4.287859041556951, "mean": 0.5954952616194853, "std": 1.2774118860610646, "bin": {"bin_50": 4.293367346938775, "bin_100": 6.68218085106383, "bin_250": 9.099193795285233, "bin_500": 9.435196485233098}}, "pval": {"value": 1.804035098262879e-05, "mean": 0.5106657090472662, "std": 0.3695881914917919, "bin": {"bin_50": 0.2145132052152406, "bin_100": 0.0125141686162342, "bin_250": 2.703368912472048e-06, "bin_500": 8.713926420505281e-10}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 26, 151, 514, 515, 651, 407, 526, 527, 62, 855, 179, 297, 298, 797, 71, 603, 814, 458, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 958, 651, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 603, 258, 907, 1191, 2358, 912, 71, 855, 1209, 62, 713]}}, "Activation of puma and translocation to mitochondria": {"direction": "dw", "overlap": {"value": 1, "mean": 0.7330097087378641, "std": 0.5228540700295993, "bin": {}}, "setsize": {"value": 1, "mean": 1.162621359223301, "std": 0.3690198541375071, "bin": {}}, "score": {"value": -4.287169231275237, "mean": -0.5561171861577721, "std": 1.5129787438401543, "bin": {}}, "pval": {"value": 1.809644292327661e-05, "mean": 0.3650727293334069, "std": 0.3122295059792732, "bin": {}}, "signature_idxs": {"edge": [3022], "full": [3022]}}, "Tp53 regulates transcription of genes involved in cytochrome c release": {"direction": "dw", "overlap": {"value": 1, "mean": 0.9320388349514565, "std": 0.7537883084963756, "bin": {}}, "setsize": {"value": 1, "mean": 2.116504854368932, "std": 0.9532873207988516, "bin": {}}, "score": {"value": -4.287169231275237, "mean": -0.1942301728903818, "std": 1.2021375713505351, "bin": {}}, "pval": {"value": 1.809644292327661e-05, "mean": 0.5263106932419677, "std": 0.3330559901269016, "bin": {}}, "signature_idxs": {"edge": [3022], "full": [3022]}}, "Regulation of tp53 activity through association with co factors": {"direction": "dw", "overlap": {"value": 1, "mean": 0.7475728155339806, "std": 0.7135096709387623, "bin": {}}, "setsize": {"value": 1, "mean": 2.2184466019417477, "std": 0.7826079841513152, "bin": {}}, "score": {"value": -4.287169231275237, "mean": 0.2392790369531503, "std": 1.1623199725678313, "bin": {}}, "pval": {"value": 1.809644292327661e-05, "mean": 0.526300735902535, "std": 0.3292675693275012, "bin": {}}, "signature_idxs": {"edge": [3022], "full": [3022]}}, "Activation of noxa and translocation to mitochondria": {"direction": "dw", "overlap": {"value": 1, "mean": 0.6650485436893204, "std": 0.5161863022343619, "bin": {}}, "setsize": {"value": 1, "mean": 1.0631067961165048, "std": 0.2431549473081202, "bin": {}}, "score": {"value": -4.287169231275237, "mean": -0.4921286550255417, "std": 1.5360699960252742, "bin": {}}, "pval": {"value": 1.809644292327661e-05, "mean": 0.3500305338995561, "std": 0.3039436373636187, "bin": {}}, "signature_idxs": {"edge": [3022], "full": [3022]}}, "Antigen processing ubiquitination proteasome degradation": {"direction": "up", "overlap": {"value": 45, "mean": 25.228155339805824, "std": 12.844717984151089, "bin": {"bin_50": 2, "bin_100": 5, "bin_250": 14, "bin_500": 28}}, "setsize": {"value": 102, "mean": 89.88592233009709, "std": 7.994482069951932, "bin": {"bin_50": 250, "bin_100": 250, "bin_250": 250, "bin_500": 250}}, "score": {"value": 4.283107552713648, "mean": 0.3040503636743611, "std": 1.4235342488403817, "bin": {"bin_50": 1.6985243651338366, "bin_100": 2.1389491966999565, "bin_250": 2.4621179197450385, "bin_500": 2.542917385470577}}, "pval": {"value": 1.8430102735500498e-05, "mean": 0.5349081840989588, "std": 0.383588489924638, "bin": {"bin_50": 0.3389463545940903, "bin_100": 0.0958446637688343, "bin_250": 0.0031748985194405, "bin_500": 3.386896740291646e-05}}, "signature_idxs": {"edge": [2, 746, 370, 373, 738, 678, 713, 258, 435, 26, 832, 151, 308, 514, 515, 651, 181, 863, 862, 527, 526, 407, 62, 855, 179, 297, 298, 343, 71, 480, 204, 477, 603, 770, 331, 381, 458, 103, 98, 568, 224, 225, 227, 115, 590], "full": [1022, 1088, 568, 26, 1024, 1629, 958, 651, 2189, 1874, 1172, 98, 2116, 797, 1040, 885, 590, 115, 407, 224, 514, 515, 458, 225, 1106, 2996, 370, 373, 1258, 227, 738, 526, 331, 297, 1575, 2654, 527, 678, 2051, 103, 151, 814, 298, 179, 603, 181, 746, 1744, 258, 2588, 907, 381, 1131, 1057, 1276, 1191, 1674, 1675, 2425, 2592, 2358, 204, 912, 1356, 832, 477, 1060, 1358, 308, 1988, 1597, 2910, 480, 1286, 1516, 1364, 1139, 343, 2, 71, 1293, 1526, 770, 2162, 855, 1209, 435, 1149, 2919, 1936, 862, 2844, 2248, 1782, 3120, 3169, 62, 1713, 863, 713, 1388, 1020]}}, "Cdt1 association with the cdc6 orc origin complex": {"direction": "up", "overlap": {"value": 29, "mean": 11.8373786407767, "std": 6.7665841522618235, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 16}}, "setsize": {"value": 41, "mean": 39.713592233009706, "std": 1.8864642297262784, "bin": {"bin_50": 54, "bin_100": 54, "bin_250": 54, "bin_500": 54}}, "score": {"value": 4.268939288063926, "mean": 0.7088745358379469, "std": 1.2345641700762902, "bin": {"bin_50": 3.967767295597484, "bin_100": 6.1556372549019605, "bin_250": 8.287029288702929, "bin_500": 8.438523695129941}}, "pval": {"value": 1.9640471314197328e-05, "mean": 0.5132999135100862, "std": 0.3668156388656303, "bin": {"bin_50": 0.2295798469686227, "bin_100": 0.0154029461510805, "bin_250": 5.271384236680569e-06, "bin_500": 3.112815609126704e-09}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 26, 151, 514, 515, 651, 407, 526, 527, 62, 855, 179, 297, 298, 797, 71, 814, 458, 570, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 958, 1796, 570, 651, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 258, 907, 2358, 912, 71, 855, 1209, 1156, 62, 713]}}, "Cross presentation of soluble exogenous antigens endosomes": {"direction": "up", "overlap": {"value": 28, "mean": 11.097087378640778, "std": 6.457500437861876, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 16}}, "setsize": {"value": 38, "mean": 36.91019417475728, "std": 1.2421375880066114, "bin": {"bin_50": 41, "bin_100": 41, "bin_250": 41, "bin_500": 41}}, "score": {"value": 4.267041025891438, "mean": 0.6471378136535638, "std": 1.2717860238430438, "bin": {"bin_50": 5.2640625, "bin_100": 8.272203947368421, "bin_250": 11.668933054393303, "bin_500": 12.843817427385892}}, "pval": {"value": 1.9808274305699317e-05, "mean": 0.507052502601231, "std": 0.3672755762882163, "bin": {"bin_50": 0.1795501084992132, "bin_100": 0.0072464589525271, "bin_250": 4.576115118035804e-07, "bin_500": 2.746850764962888e-11}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 26, 151, 514, 515, 651, 407, 527, 526, 62, 855, 179, 297, 298, 797, 71, 814, 458, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 958, 651, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 258, 907, 2358, 912, 71, 855, 1209, 62, 713]}}, "Degradation of axin": {"direction": "up", "overlap": {"value": 28, "mean": 11.135922330097088, "std": 6.515923056292238, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 16}}, "setsize": {"value": 38, "mean": 36.5, "std": 1.1005294401076644, "bin": {"bin_50": 48, "bin_100": 48, "bin_250": 48, "bin_500": 48}}, "score": {"value": 4.267041025891438, "mean": 0.6371703324335989, "std": 1.2875505119575097, "bin": {"bin_50": 4.476950354609929, "bin_100": 6.980555555555555, "bin_250": 9.567750241390408, "bin_500": 10.026970954356846}}, "pval": {"value": 1.9808274305699317e-05, "mean": 0.5044883973483546, "std": 0.3689236351245595, "bin": {"bin_50": 0.2068720246529641, "bin_100": 0.0111977735740575, "bin_250": 1.8880465635327943e-06, "bin_500": 4.3704554544344234e-10}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 26, 151, 514, 515, 651, 407, 527, 526, 62, 855, 179, 297, 298, 797, 71, 814, 458, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 958, 651, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 258, 907, 2358, 912, 71, 855, 1209, 62, 713]}}, "Auf1 hnrnp d0 binds and destabilizes mrna": {"direction": "up", "overlap": {"value": 29, "mean": 12.29126213592233, "std": 6.997407381130411, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 16}}, "setsize": {"value": 43, "mean": 41.32281553398058, "std": 1.1321274049849332, "bin": {"bin_50": 48, "bin_100": 48, "bin_250": 48, "bin_500": 48}}, "score": {"value": 4.262683472077982, "mean": 0.5322843325278358, "std": 1.2756329236795467, "bin": {"bin_50": 4.476950354609929, "bin_100": 6.980555555555555, "bin_250": 9.567750241390408, "bin_500": 10.026970954356846}}, "pval": {"value": 2.0198653535752346e-05, "mean": 0.5313716896545542, "std": 0.3681225669284069, "bin": {"bin_50": 0.2068720246529641, "bin_100": 0.0111977735740575, "bin_250": 1.8880465635327943e-06, "bin_500": 4.3704554544344234e-10}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 26, 151, 514, 515, 651, 657, 407, 527, 526, 62, 855, 179, 297, 797, 298, 71, 814, 458, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 958, 651, 2118, 657, 1559, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 1268, 258, 907, 1901, 2358, 912, 71, 855, 1209, 62, 713]}}, "Diseases of base excision repair": {"direction": "dw", "overlap": {"value": 1, "mean": 0.4455445544554455, "std": 0.4970257583370746, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -4.258991671792344, "mean": 0.1724457009053418, "std": 1.741038608021514, "bin": {}}, "pval": {"value": 2.053511201838276e-05, "mean": 0.2842889429599091, "std": 0.2793668788004896, "bin": {}}, "signature_idxs": {"edge": [3000], "full": [3000]}}, "Ldl remodeling": {"direction": "dw", "overlap": {"value": 1, "mean": 0.3762135922330097, "std": 0.484434644975093, "bin": {}}, "setsize": {"value": 1, "mean": 1.0412621359223302, "std": 0.1988958824648143, "bin": {}}, "score": {"value": -4.249578684277943, "mean": 0.4524564840845338, "std": 1.7492235868086068, "bin": {}}, "pval": {"value": 2.1417296792947127e-05, "mean": 0.2588466426630615, "std": 0.2637058180320269, "bin": {}}, "signature_idxs": {"edge": [2993], "full": [2993]}}, "Chylomicron assembly": {"direction": "dw", "overlap": {"value": 1, "mean": 0.5849514563106796, "std": 0.5912523713064913, "bin": {}}, "setsize": {"value": 1, "mean": 1.6504854368932038, "std": 0.556667230154355, "bin": {}}, "score": {"value": -4.249578684277943, "mean": 0.4536199301800213, "std": 1.4329848057763246, "bin": {}}, "pval": {"value": 2.1417296792947127e-05, "mean": 0.4246042979641416, "std": 0.338971958034201, "bin": {}}, "signature_idxs": {"edge": [2993], "full": [2993]}}, "Vldl assembly": {"direction": "dw", "overlap": {"value": 1, "mean": 0.3859223300970874, "std": 0.4868123716890544, "bin": {}}, "setsize": {"value": 1, "mean": 1.055825242718447, "std": 0.2295839388848294, "bin": {}}, "score": {"value": -4.249578684277943, "mean": 0.4444296262971679, "std": 1.732992762683887, "bin": {}}, "pval": {"value": 2.1417296792947127e-05, "mean": 0.2612696954788275, "std": 0.2638395369031528, "bin": {}}, "signature_idxs": {"edge": [2993], "full": [2993]}}, "Activated ntrk3 signals through pi3k": {"direction": "up", "overlap": {"value": 0, "mean": 0.5, "std": 0.5, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 4.242223159045616, "mean": 0.017931794920508, "std": 1.9369544641551677, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 13.421052631578949, "bin_500": 6.502347417840376}}, "pval": {"value": 2.213164607667295e-05, "mean": 0.2329965499633163, "std": 0.268643918034951, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0938138368307335, "bin_500": 0.1815422125939431}}, "signature_idxs": {"edge": [], "full": [201]}}, "Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s": {"direction": "up", "overlap": {"value": 37, "mean": 21.27912621359223, "std": 8.810973476604579, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 3, "bin_500": 12}}, "setsize": {"value": 52, "mean": 50.43446601941748, "std": 1.4474874301684992, "bin": {"bin_50": 59, "bin_100": 59, "bin_250": 59, "bin_500": 59}}, "score": {"value": 4.240183082647362, "mean": -0.6423341772855271, "std": 1.4039245476891489, "bin": {"bin_50": 3.623922413793104, "bin_100": 1.766185784658691, "bin_250": 2.1629737609329447, "bin_500": 5.070133963750985}}, "pval": {"value": 2.2333755136605404e-05, "mean": 0.4501870221883518, "std": 0.3707470696386276, "bin": {"bin_50": 0.2480154974279715, "bin_100": 0.4386006499544391, "bin_250": 0.1728856135395864, "bin_500": 2.2100791839153253e-05}}, "signature_idxs": {"edge": [680, 513, 836, 679, 903, 529, 901, 405, 899, 902, 48, 180, 656, 416, 293, 803, 670, 751, 825, 817, 815, 581, 954, 450, 816, 957, 968, 468, 602, 104, 471, 982, 470, 395, 721, 601, 359], "full": [954, 1393, 957, 1330, 450, 581, 359, 721, 656, 1559, 405, 1561, 513, 968, 1247, 2806, 670, 803, 293, 2701, 1891, 1968, 1119, 1264, 468, 899, 104, 982, 601, 470, 901, 471, 815, 816, 679, 902, 817, 416, 180, 48, 903, 602, 1420, 680, 529, 1268, 751, 1590, 825, 836, 395, 1086]}}, "Regulation of pten stability and activity": {"direction": "up", "overlap": {"value": 30, "mean": 12.611650485436892, "std": 7.056269001912706, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 17}}, "setsize": {"value": 42, "mean": 41.82281553398058, "std": 2.1755846965350556, "bin": {"bin_50": 63, "bin_100": 63, "bin_250": 63, "bin_500": 63}}, "score": {"value": 4.226781047905291, "mean": 0.6486618107800725, "std": 1.2659780846667748, "bin": {"bin_50": 3.38877688172043, "bin_100": 5.227604166666667, "bin_250": 6.899581589958159, "bin_500": 7.415890807195155}}, "pval": {"value": 2.3705813285923583e-05, "mean": 0.5229501310802542, "std": 0.3745012259374719, "bin": {"bin_50": 0.2624522374738631, "bin_100": 0.0231701844530087, "bin_250": 1.938820972149405e-05, "bin_500": 4.9010078689633335e-09}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 26, 151, 514, 515, 651, 863, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 814, 458, 568, 224, 225, 227, 115, 364, 590], "full": [1088, 568, 26, 1024, 1629, 958, 651, 2694, 797, 364, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 1421, 258, 907, 2358, 912, 71, 855, 1209, 62, 863, 713]}}, "Assembly of the hiv virion": {"direction": "up", "overlap": {"value": 0, "mean": 0.9344660194174758, "std": 0.8023487706827959, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 2.1529126213592233, "std": 0.8580946731527521, "bin": {"bin_50": 15, "bin_100": 15, "bin_250": 15, "bin_500": 15}}, "score": {"value": 4.224938931184695, "mean": 0.3047134577144255, "std": 1.310058918536931, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 2.872758820127242, "bin_500": 1.3917792469100316}}, "pval": {"value": 2.3900558199230204e-05, "mean": 0.4409087176021088, "std": 0.3022297606678077, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.3090006421698555, "bin_500": 0.5284199673110125}}, "signature_idxs": {"edge": [], "full": [241]}}, "Cd22 mediated bcr regulation": {"direction": "up", "overlap": {"value": 0, "mean": 0.5263157894736842, "std": 0.4993069989739546, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 2, "bin_100": 2, "bin_250": 2, "bin_500": 2}}, "score": {"value": 4.206043961436274, "mean": -0.0903878459510875, "std": 1.8723737158182567, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 40.27125506072875, "bin_500": 19.51106639839034}}, "pval": {"value": 2.598797026198696e-05, "mean": 0.2653007829531221, "std": 0.2847568281551553, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0480572346493884, "bin_500": 0.095304315936589}}, "signature_idxs": {"edge": [], "full": [219]}}, "Dectin 2 family": {"direction": "up", "overlap": {"value": 0, "mean": 0.5309278350515464, "std": 0.4990425523129508, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0360824742268042, "std": 0.1864953867538716, "bin": {"bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 4.206043961436274, "mean": -0.1856771861692833, "std": 1.8062742038775033, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 13.421052631578949, "bin_500": 6.502347417840376}}, "pval": {"value": 2.598797026198696e-05, "mean": 0.2926987335480353, "std": 0.305466755235511, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0938138368307335, "bin_500": 0.1815422125939431}}, "signature_idxs": {"edge": [], "full": [219]}}, "Erythropoietin activates phosphoinositide 3 kinase pi3k": {"direction": "up", "overlap": {"value": 0, "mean": 0.5263157894736842, "std": 0.4993069989739546, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 8, "bin_100": 8, "bin_250": 8, "bin_500": 8}}, "score": {"value": 4.206043961436274, "mean": -0.0903878459510875, "std": 1.8723737158182567, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 5.749566223250434, "bin_500": 2.785570566254671}}, "pval": {"value": 2.598797026198696e-05, "mean": 0.2653007829531221, "std": 0.2847568281551553, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1788587842302525, "bin_500": 0.3301808657155594}}, "signature_idxs": {"edge": [], "full": [219]}}, "Erythropoietin activates stat5": {"direction": "up", "overlap": {"value": 0, "mean": 0.5321637426900585, "std": 0.4989644212327846, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.04093567251462, "std": 0.1981412204221919, "bin": {"bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 4.206043961436274, "mean": -0.064901478255002, "std": 1.8520317050534485, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 13.421052631578949, "bin_500": 6.502347417840376}}, "pval": {"value": 2.598797026198696e-05, "mean": 0.2781306412743365, "std": 0.2981708210891899, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0938138368307335, "bin_500": 0.1815422125939431}}, "signature_idxs": {"edge": [], "full": [219]}}, "G1 s dna damage checkpoints": {"direction": "up", "overlap": {"value": 31, "mean": 12.276699029126211, "std": 7.080750657966309, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 17}}, "setsize": {"value": 42, "mean": 40.3252427184466, "std": 1.8659034848764728, "bin": {"bin_50": 61, "bin_100": 61, "bin_250": 61, "bin_500": 61}}, "score": {"value": 4.18802707080649, "mean": 0.5620621733571898, "std": 1.2552712987328345, "bin": {"bin_50": 3.502430555555556, "bin_100": 5.408943965517241, "bin_250": 7.166398455101384, "bin_500": 7.754583254583254}}, "pval": {"value": 2.813899588427482e-05, "mean": 0.5261130346169095, "std": 0.3710523646543767, "bin": {"bin_50": 0.2552681350600493, "bin_100": 0.0212914346042941, "bin_250": 1.4820531230257533e-05, "bin_500": 2.844826964209396e-09}}, "signature_idxs": {"edge": [370, 589, 373, 738, 258, 713, 26, 151, 514, 515, 651, 407, 527, 526, 62, 855, 179, 297, 797, 298, 802, 71, 814, 458, 568, 224, 225, 227, 115, 590, 357], "full": [1088, 568, 26, 1024, 357, 1629, 958, 651, 3022, 797, 1040, 589, 590, 115, 407, 224, 514, 515, 458, 225, 370, 802, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 258, 907, 2358, 912, 71, 855, 1209, 62, 713]}}, "Srp dependent cotranslational protein targeting to membrane": {"direction": "up", "overlap": {"value": 54, "mean": 36.76699029126213, "std": 17.22196829379636, "bin": {"bin_50": 2, "bin_100": 4, "bin_250": 10, "bin_500": 24}}, "setsize": {"value": 89, "mean": 90.33495145631068, "std": 2.057296214960333, "bin": {"bin_50": 108, "bin_100": 108, "bin_250": 108, "bin_500": 108}}, "score": {"value": 4.172069233629862, "mean": -0.5167678337360311, "std": 1.7319679229133378, "bin": {"bin_50": 4.030911280610197, "bin_100": 4.045748987854251, "bin_250": 4.223117818555994, "bin_500": 5.795057263411694}}, "pval": {"value": 3.018458841408389e-05, "mean": 0.4521019696915908, "std": 0.3837080047653741, "bin": {"bin_50": 0.0948632313276182, "bin_100": 0.0207919883966976, "bin_250": 0.0002894285059084, "bin_500": 2.735490798471197e-10}}, "signature_idxs": {"edge": [974, 681, 680, 133, 565, 513, 27, 873, 150, 679, 153, 905, 903, 529, 300, 902, 901, 405, 48, 899, 180, 894, 656, 416, 412, 299, 293, 803, 799, 604, 636, 818, 605, 86, 817, 84, 815, 813, 816, 379, 456, 457, 464, 602, 468, 104, 471, 226, 469, 470, 982, 981, 721, 601], "full": [873, 2407, 1952, 3091, 84, 2410, 721, 656, 27, 405, 2412, 1038, 456, 513, 1247, 457, 799, 1042, 973, 1494, 1255, 1180, 2806, 1409, 2127, 1654, 86, 2343, 974, 894, 226, 464, 803, 293, 2701, 150, 1571, 1735, 412, 2477, 2653, 468, 2050, 981, 899, 1189, 813, 1578, 3093, 469, 104, 982, 601, 470, 901, 471, 815, 816, 679, 902, 299, 817, 818, 416, 1123, 180, 48, 903, 602, 1420, 680, 681, 300, 1124, 133, 604, 605, 2810, 529, 379, 1050, 153, 1666, 905, 1128, 2062, 636, 565, 2321]}}, "Met receptor activation": {"direction": "dw", "overlap": {"value": 1, "mean": 0.7168674698795181, "std": 0.4505202553804394, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -4.164395942268312, "mean": -0.9219299017623342, "std": 1.841688628241337, "bin": {}}, "pval": {"value": 3.1217796168991896e-05, "mean": 0.2314921223213593, "std": 0.2692096463129164, "bin": {}}, "signature_idxs": {"edge": [2980], "full": [2980]}}, "Regulation of tlr by endogenous ligand": {"direction": "up", "overlap": {"value": 0, "mean": 0.3713592233009709, "std": 0.507664648395439, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.2354368932038835, "std": 0.4242715669502102, "bin": {"bin_50": 3, "bin_100": 3, "bin_250": 3, "bin_500": 3}}, "score": {"value": 4.147523069781924, "mean": 0.7184981365294011, "std": 1.5524015172237715, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 9.754527162977867}}, "pval": {"value": 3.3609161293135514e-05, "mean": 0.3286185173125904, "std": 0.3086949554304918, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.1395007501750084}}, "signature_idxs": {"edge": [], "full": [251]}}, "Irak4 deficiency tlr2 4": {"direction": "up", "overlap": {"value": 0, "mean": 0.3422330097087379, "std": 0.4744571390277913, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 4.147523069781924, "mean": 0.609545248047655, "std": 1.6565339651030313, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 6.502347417840376}}, "pval": {"value": 3.3609161293135514e-05, "mean": 0.3053722889112167, "std": 0.2977526711488896, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.1815422125939431}}, "signature_idxs": {"edge": [], "full": [251]}}, "Runx2 regulates chondrocyte maturation": {"direction": "up", "overlap": {"value": 0, "mean": 0.4601226993865031, "std": 0.4984072640880956, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 3, "bin_100": 3, "bin_250": 3, "bin_500": 3}}, "score": {"value": 4.139584324461803, "mean": 0.1732448527546716, "std": 1.788366377799902, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 9.754527162977867}}, "pval": {"value": 3.4793569217317355e-05, "mean": 0.2460835663283863, "std": 0.2527409036223455, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.1395007501750084}}, "signature_idxs": {"edge": [], "full": [259]}}, "Runx1 regulates transcription of genes involved in wnt signaling": {"direction": "up", "overlap": {"value": 0, "mean": 0.4601226993865031, "std": 0.4984072640880956, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 3, "bin_100": 3, "bin_250": 3, "bin_500": 3}}, "score": {"value": 4.139584324461803, "mean": 0.1732448527546716, "std": 1.788366377799902, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 9.754527162977867}}, "pval": {"value": 3.4793569217317355e-05, "mean": 0.2460835663283863, "std": 0.2527409036223455, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.1395007501750084}}, "signature_idxs": {"edge": [], "full": [259]}}, "Runx1 regulates transcription of genes involved in interleukin signaling": {"direction": "up", "overlap": {"value": 0, "mean": 0.4601226993865031, "std": 0.4984072640880956, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 4.139584324461803, "mean": 0.1732448527546716, "std": 1.788366377799902, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 6.502347417840376}}, "pval": {"value": 3.4793569217317355e-05, "mean": 0.2460835663283863, "std": 0.2527409036223455, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.1815422125939431}}, "signature_idxs": {"edge": [], "full": [259]}}, "Runx1 regulates transcription of genes involved in bcr signaling": {"direction": "up", "overlap": {"value": 0, "mean": 0.6203208556149733, "std": 0.6032123487573721, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.1764705882352942, "std": 0.3812200410828152, "bin": {"bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 4.139584324461803, "mean": -0.0607428349658002, "std": 1.8214332905131796, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 6.502347417840376}}, "pval": {"value": 3.4793569217317355e-05, "mean": 0.2798420771747998, "std": 0.2970040743955078, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.1815422125939431}}, "signature_idxs": {"edge": [], "full": [259]}}, "Runx2 regulates genes involved in cell migration": {"direction": "up", "overlap": {"value": 0, "mean": 0.4720670391061452, "std": 0.586678631564853, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.6340782122905029, "std": 0.6952838852106926, "bin": {"bin_50": 5, "bin_100": 5, "bin_250": 5, "bin_500": 5}}, "score": {"value": 4.139584324461803, "mean": 1.0202612189411668, "std": 1.4141525202568348, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 4.8762575452716295}}, "pval": {"value": 3.4793569217317355e-05, "mean": 0.3350810536365994, "std": 0.3189479641011906, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.2215335762210877}}, "signature_idxs": {"edge": [], "full": [259]}}, "Runx1 regulates estrogen receptor mediated transcription": {"direction": "up", "overlap": {"value": 0, "mean": 0.2949852507374631, "std": 0.4812148923753463, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.2536873156342183, "std": 0.4351207436109232, "bin": {"bin_50": 5, "bin_100": 5, "bin_250": 5, "bin_500": 5}}, "score": {"value": 4.139584324461803, "mean": 1.1732058398887657, "std": 1.8086643698442468, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 4.8762575452716295}}, "pval": {"value": 3.4793569217317355e-05, "mean": 0.2207623739349291, "std": 0.280217744978931, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.2215335762210877}}, "signature_idxs": {"edge": [], "full": [259]}}, "Runx3 regulates immune response and cell migration": {"direction": "up", "overlap": {"value": 0, "mean": 0.4601226993865031, "std": 0.4984072640880956, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 4.139584324461803, "mean": 0.1732448527546716, "std": 1.788366377799902, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 6.502347417840376}}, "pval": {"value": 3.4793569217317355e-05, "mean": 0.2460835663283863, "std": 0.2527409036223455, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.1815422125939431}}, "signature_idxs": {"edge": [], "full": [259]}}, "Runx1 and foxp3 control the development of regulatory t lymphocytes tregs": {"direction": "up", "overlap": {"value": 0, "mean": 0.4601226993865031, "std": 0.4984072640880956, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 3, "bin_100": 3, "bin_250": 3, "bin_500": 3}}, "score": {"value": 4.139584324461803, "mean": 0.1732448527546716, "std": 1.788366377799902, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 9.754527162977867}}, "pval": {"value": 3.4793569217317355e-05, "mean": 0.2460835663283863, "std": 0.2527409036223455, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.1395007501750084}}, "signature_idxs": {"edge": [], "full": [259]}}, "Runx1 regulates transcription of genes involved in differentiation of keratinocytes": {"direction": "up", "overlap": {"value": 0, "mean": 0.4545454545454545, "std": 0.4979295977319691, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 4.139584324461803, "mean": 0.2245429409825668, "std": 1.8230637284381137, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 6.502347417840376}}, "pval": {"value": 3.4793569217317355e-05, "mean": 0.2439729517853924, "std": 0.2583716515239901, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.1815422125939431}}, "signature_idxs": {"edge": [], "full": [259]}}, "Signaling by notch4": {"direction": "up", "overlap": {"value": 35, "mean": 12.74271844660194, "std": 7.095179574371064, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 17}}, "setsize": {"value": 44, "mean": 42.689320388349515, "std": 1.5202779907622044, "bin": {"bin_50": 71, "bin_100": 71, "bin_250": 71, "bin_500": 71}}, "score": {"value": 4.133635521690538, "mean": 0.5846962923720355, "std": 1.22282479858509, "bin": {"bin_50": 2.999107142857143, "bin_100": 4.608915441176471, "bin_250": 6.81016668962667, "bin_500": 6.312004312004312}}, "pval": {"value": 3.570695845533933e-05, "mean": 0.527528574888472, "std": 0.3678962187540617, "bin": {"bin_50": 0.290515894493261, "bin_100": 0.0315581274962669, "bin_250": 7.58069668538433e-06, "bin_500": 3.4826271570672084e-08}}, "signature_idxs": {"edge": [590, 370, 373, 738, 258, 713, 26, 1057, 151, 514, 515, 651, 181, 1024, 907, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 603, 814, 958, 458, 568, 224, 225, 227, 115, 912], "full": [1088, 568, 26, 1024, 1629, 958, 651, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 603, 2348, 181, 258, 2703, 907, 2060, 1057, 912, 71, 855, 1209, 62, 713, 2030]}}, "G2 m checkpoints": {"direction": "up", "overlap": {"value": 41, "mean": 20.961165048543688, "std": 11.249096904504546, "bin": {"bin_50": 3, "bin_100": 6, "bin_250": 13, "bin_500": 24}}, "setsize": {"value": 83, "mean": 83.21601941747574, "std": 6.6438113169442845, "bin": {"bin_50": 134, "bin_100": 134, "bin_250": 134, "bin_500": 134}}, "score": {"value": 4.12130991447133, "mean": 0.2497590522742128, "std": 1.0983784482763044, "bin": {"bin_50": 4.98639230003319, "bin_100": 5.024697580645161, "bin_250": 4.492737823105328, "bin_500": 4.413348676639816}}, "pval": {"value": 3.767242353425182e-05, "mean": 0.6198120617040068, "std": 0.3587806160447286, "bin": {"bin_50": 0.0263546681411107, "bin_100": 0.0019001939744845, "bin_250": 2.2069270229140197e-05, "bin_500": 2.6117887880750817e-08}}, "signature_idxs": {"edge": [357, 369, 370, 9, 373, 738, 848, 21, 258, 713, 26, 151, 511, 514, 515, 651, 527, 526, 407, 62, 855, 179, 292, 297, 298, 71, 329, 96, 458, 103, 570, 568, 731, 224, 225, 726, 227, 115, 591, 590, 589], "full": [1088, 568, 26, 1024, 357, 1629, 958, 1796, 570, 2459, 651, 2402, 2116, 2637, 3022, 511, 726, 1242, 797, 1040, 589, 1489, 590, 115, 407, 224, 970, 591, 514, 515, 458, 225, 2700, 731, 1407, 1252, 21, 329, 369, 370, 3063, 292, 1496, 373, 1258, 227, 738, 1186, 2649, 526, 2581, 297, 527, 103, 151, 1122, 814, 298, 1579, 179, 1351, 2348, 1269, 258, 2215, 907, 1591, 2906, 2358, 912, 71, 848, 2373, 855, 1209, 2833, 2377, 9, 96, 1156, 62, 713, 1941]}}, "Tnfr1 mediated ceramide production": {"direction": "up", "overlap": {"value": 0, "mean": 0.720873786407767, "std": 0.4485696941144109, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 3, "bin_100": 3, "bin_250": 3, "bin_500": 3}}, "score": {"value": 4.10297162309979, "mean": -1.0208892096662905, "std": 1.827171007388144, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 9.754527162977867}}, "pval": {"value": 4.0787729247870885e-05, "mean": 0.2297852023292357, "std": 0.2821514571367339, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.1395007501750084}}, "signature_idxs": {"edge": [], "full": [301]}}, "Adaptive immune system": {"direction": "up", "overlap": {"value": 82, "mean": 46.463592233009706, "std": 20.006579857169463, "bin": {"bin_50": 5, "bin_100": 8, "bin_250": 25, "bin_500": 48}}, "setsize": {"value": 199, "mean": 186.4004854368932, "std": 16.487632898609263, "bin": {"bin_50": 504, "bin_100": 504, "bin_250": 504, "bin_500": 504}}, "score": {"value": 4.087128082633592, "mean": 0.1339433536175087, "std": 1.0633527271457623, "bin": {"bin_50": 2.1971215157587904, "bin_100": 1.7017015242821694, "bin_250": 2.216173455536104, "bin_500": 2.16187134502924}}, "pval": {"value": 4.367460273857482e-05, "mean": 0.6962113214501324, "std": 0.3569087738025599, "bin": {"bin_50": 0.0930288768577385, "bin_100": 0.1160830456463026, "bin_250": 0.0005491326949492, "bin_500": 5.9316137000778e-06}}, "signature_idxs": {"edge": [2, 8, 26, 31, 514, 515, 34, 527, 526, 62, 608, 71, 635, 603, 578, 103, 98, 568, 115, 597, 116, 590, 143, 127, 678, 713, 151, 651, 181, 179, 675, 169, 665, 204, 201, 202, 236, 770, 219, 224, 225, 227, 270, 748, 746, 738, 251, 258, 832, 308, 302, 863, 283, 862, 855, 296, 297, 797, 298, 343, 814, 331, 381, 923, 390, 933, 912, 942, 370, 373, 885, 435, 870, 874, 904, 401, 407, 480, 477, 475, 458, 465], "full": [1022, 870, 283, 1088, 568, 26, 1024, 1629, 1225, 169, 958, 1549, 959, 1872, 651, 127, 2189, 874, 1874, 2635, 1639, 2990, 1641, 1172, 98, 963, 578, 2116, 2572, 1726, 401, 1877, 2576, 2409, 2119, 1238, 219, 251, 1558, 2259, 1879, 201, 34, 1403, 797, 1485, 1040, 885, 590, 115, 407, 224, 2901, 2125, 514, 515, 458, 225, 1106, 2523, 665, 1566, 2996, 2700, 1251, 370, 597, 2342, 373, 8, 465, 1258, 227, 738, 1415, 1261, 2130, 526, 1817, 331, 296, 1574, 675, 1346, 297, 202, 1575, 1049, 2653, 2654, 527, 1661, 678, 2051, 103, 1121, 151, 3093, 814, 298, 179, 603, 31, 1266, 904, 2052, 2348, 2135, 181, 746, 302, 2937, 1824, 3155, 1744, 116, 258, 475, 748, 1899, 3027, 2588, 986, 907, 381, 1131, 2589, 608, 1057, 1276, 1191, 1674, 236, 1675, 2425, 1431, 1676, 2592, 1592, 1903, 2358, 204, 912, 1356, 832, 477, 1060, 1433, 3129, 1062, 1358, 308, 1988, 1597, 2910, 480, 1286, 1516, 1364, 923, 1139, 343, 2, 71, 1072, 1293, 1526, 2000, 270, 770, 2162, 855, 1209, 933, 143, 1211, 435, 1149, 390, 2090, 2919, 1936, 635, 942, 862, 2023, 2844, 2248, 1782, 3120, 3169, 62, 1713, 863, 713, 1388, 1320, 1020, 1322]}}, "Vitamin d calciferol metabolism": {"direction": "dw", "overlap": {"value": 1, "mean": 1.2160194174757282, "std": 0.815169098909629, "bin": {}}, "setsize": {"value": 1, "mean": 3.1601941747572817, "std": 0.9129956885685208, "bin": {}}, "score": {"value": -4.084763104233147, "mean": 0.7445815680804749, "std": 1.3106248902727975, "bin": {}}, "pval": {"value": 4.412180727042525e-05, "mean": 0.3219454249036758, "std": 0.2921839998108322, "bin": {}}, "signature_idxs": {"edge": [2895], "full": [2895]}}, "Hedgehog ligand biogenesis": {"direction": "up", "overlap": {"value": 29, "mean": 11.735436893203884, "std": 6.1754608769009325, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 16}}, "setsize": {"value": 40, "mean": 40.279126213592235, "std": 1.552402214168598, "bin": {"bin_50": 53, "bin_100": 53, "bin_250": 53, "bin_500": 53}}, "score": {"value": 4.0757961886310845, "mean": 0.705289766689403, "std": 1.168348102852658, "bin": {"bin_50": 4.044471153846154, "bin_100": 6.279375, "bin_250": 8.476226702168125, "bin_500": 8.667489065829315}}, "pval": {"value": 4.585717114191645e-05, "mean": 0.5138056150617029, "std": 0.3656259469969254, "bin": {"bin_50": 0.225839943305071, "bin_100": 0.0146485330026984, "bin_250": 4.486950937692581e-06, "bin_500": 2.292329734647898e-09}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 26, 151, 514, 515, 651, 407, 526, 527, 62, 676, 855, 179, 297, 797, 298, 71, 814, 458, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 958, 651, 2993, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 676, 527, 151, 814, 298, 179, 258, 907, 2358, 912, 71, 855, 1209, 62, 713]}}, "Tcf dependent signaling in response to wnt": {"direction": "up", "overlap": {"value": 35, "mean": 17.473300970873787, "std": 8.980116427159441, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 18}}, "setsize": {"value": 62, "mean": 61.62378640776699, "std": 3.846157738891713, "bin": {"bin_50": 142, "bin_100": 142, "bin_250": 142, "bin_500": 142}}, "score": {"value": 4.062141757864678, "mean": 0.1854387909065221, "std": 1.1264976241944151, "bin": {"bin_50": 1.4784278959810877, "bin_100": 2.238758992805755, "bin_250": 2.7789662440620377, "bin_500": 2.8953629032258066}}, "pval": {"value": 4.862453332843408e-05, "mean": 0.5928765054134378, "std": 0.36413626392076, "bin": {"bin_50": 0.4978494903048275, "bin_100": 0.1595974921362929, "bin_250": 0.0077903827628128, "bin_500": 0.0001841429516671}}, "signature_idxs": {"edge": [370, 373, 912, 738, 908, 258, 713, 26, 151, 514, 515, 444, 651, 909, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 665, 603, 814, 458, 568, 224, 225, 227, 115, 364, 590], "full": [1088, 568, 26, 1024, 1629, 1868, 958, 651, 797, 364, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 665, 1566, 2524, 370, 1655, 373, 1258, 227, 738, 1259, 2903, 526, 297, 527, 151, 814, 298, 179, 1351, 603, 2348, 1421, 1127, 258, 907, 908, 909, 1191, 1592, 2358, 912, 1904, 1062, 2364, 71, 855, 1209, 1617, 2309, 62, 713, 444, 2628]}}, "Stabilization of p53": {"direction": "up", "overlap": {"value": 29, "mean": 11.759708737864075, "std": 6.862945949053685, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 16}}, "setsize": {"value": 40, "mean": 38.849514563106794, "std": 1.536505541452464, "bin": {"bin_50": 51, "bin_100": 51, "bin_250": 51, "bin_500": 51}}, "score": {"value": 4.061232917499659, "mean": 0.5626554032387434, "std": 1.2546862993954295, "bin": {"bin_50": 4.207083333333333, "bin_100": 6.542317708333333, "bin_250": 8.881649731022115, "bin_500": 9.164671013633669}}, "pval": {"value": 4.881424054303807e-05, "mean": 0.5211156380328503, "std": 0.3691198814060923, "bin": {"bin_50": 0.2183067054048652, "bin_100": 0.0132042256106822, "bin_250": 3.2137617365813383e-06, "bin_500": 1.2133218209048239e-09}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 26, 151, 514, 515, 651, 407, 527, 526, 62, 855, 179, 297, 298, 797, 802, 71, 814, 458, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 958, 651, 3022, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 802, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 258, 907, 2358, 912, 71, 855, 1209, 62, 713]}}, "Pcp ce pathway": {"direction": "up", "overlap": {"value": 33, "mean": 13.383495145631068, "std": 7.677259284018882, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 17}}, "setsize": {"value": 52, "mean": 48.61407766990291, "std": 2.3137612538026593, "bin": {"bin_50": 78, "bin_100": 78, "bin_250": 78, "bin_500": 78}}, "score": {"value": 4.047971561014899, "mean": 0.2861400551198787, "std": 1.2152839684208736, "bin": {"bin_50": 2.7245670995670994, "bin_100": 4.175833333333333, "bin_250": 6.104794859120118, "bin_500": 5.583620190177567}}, "pval": {"value": 5.166342181328609e-05, "mean": 0.573085795011315, "std": 0.370148963517148, "bin": {"bin_50": 0.314211533829163, "bin_100": 0.0400324838097305, "bin_250": 1.7795351218322907e-05, "bin_500": 1.5341558315899181e-07}}, "signature_idxs": {"edge": [370, 373, 912, 738, 258, 713, 26, 151, 514, 515, 651, 904, 407, 526, 527, 182, 62, 855, 179, 675, 297, 797, 298, 71, 814, 458, 568, 224, 225, 227, 115, 720, 590], "full": [1088, 568, 26, 1024, 1629, 958, 651, 2635, 2572, 2409, 720, 1558, 2517, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 1493, 370, 373, 1258, 227, 738, 526, 675, 297, 527, 151, 1969, 814, 298, 179, 904, 2052, 1824, 258, 907, 182, 2358, 912, 71, 2000, 855, 1209, 62, 713]}}, "Developmental biology": {"direction": "up", "overlap": {"value": 122, "mean": 83.72815533980582, "std": 32.55971188976957, "bin": {"bin_50": 4, "bin_100": 9, "bin_250": 30, "bin_500": 59}}, "setsize": {"value": 275, "mean": 256.43203883495147, "std": 18.326402586582073, "bin": {"bin_50": 665, "bin_100": 665, "bin_250": 665, "bin_500": 665}}, "score": {"value": 4.020509983606973, "mean": -0.5814417711887411, "std": 1.2607699755195518, "bin": {"bin_50": 1.275642965204236, "bin_100": 1.4391768292682927, "bin_250": 2.018276385176624, "bin_500": 2.016388882624025}}, "pval": {"value": 5.807228804455278e-05, "mean": 0.5435048152949694, "std": 0.3604361411334405, "bin": {"bin_50": 0.3980470284424519, "bin_100": 0.1961512630539462, "bin_250": 0.0007497180054252, "bin_500": 4.6930719524429575e-06}}, "signature_idxs": {"edge": [543, 7, 565, 513, 26, 514, 515, 34, 516, 531, 529, 527, 526, 48, 62, 72, 71, 604, 605, 603, 86, 582, 84, 568, 602, 104, 115, 116, 601, 590, 589, 143, 694, 681, 680, 133, 158, 713, 164, 151, 149, 150, 679, 153, 677, 651, 657, 652, 188, 180, 642, 656, 179, 675, 201, 236, 776, 219, 752, 224, 225, 226, 227, 721, 720, 744, 738, 258, 259, 304, 832, 302, 300, 855, 297, 797, 298, 299, 293, 803, 799, 790, 818, 821, 822, 817, 815, 814, 813, 812, 816, 379, 923, 364, 912, 370, 373, 430, 878, 910, 905, 401, 904, 902, 903, 901, 907, 899, 407, 409, 405, 416, 412, 477, 456, 457, 458, 468, 471, 469, 470, 464], "full": [1088, 568, 26, 3121, 1024, 642, 1628, 1629, 1631, 1166, 1717, 790, 1474, 2888, 958, 2256, 1637, 2257, 1329, 1798, 1722, 3214, 651, 2931, 2036, 2796, 2635, 1641, 1098, 2572, 652, 1726, 401, 2406, 3091, 84, 2576, 1956, 720, 1237, 1238, 219, 7, 878, 721, 656, 1558, 2517, 657, 1241, 1559, 201, 582, 1483, 1808, 149, 1037, 405, 1883, 34, 1403, 797, 2412, 1038, 2471, 456, 2193, 1485, 2038, 2641, 364, 1040, 513, 1041, 1809, 2698, 589, 1247, 590, 115, 407, 224, 1105, 457, 799, 514, 515, 458, 225, 516, 1042, 2338, 973, 1731, 2042, 2524, 1408, 1494, 1568, 2200, 1888, 370, 1179, 1255, 2415, 2806, 1409, 1654, 409, 86, 373, 974, 894, 226, 464, 803, 293, 2701, 1183, 150, 1258, 1571, 1658, 227, 738, 1259, 1415, 412, 2903, 526, 1964, 675, 297, 677, 744, 468, 527, 1661, 1577, 812, 899, 151, 1189, 813, 1578, 1969, 469, 2529, 104, 814, 298, 982, 601, 470, 901, 471, 815, 816, 679, 902, 179, 299, 1663, 1350, 817, 818, 416, 1351, 1123, 180, 48, 903, 602, 1420, 680, 2904, 603, 681, 300, 1124, 133, 604, 605, 1266, 904, 2052, 2810, 529, 1421, 302, 379, 1050, 153, 531, 1824, 2269, 1190, 2137, 1666, 304, 905, 1268, 1896, 116, 258, 2703, 1128, 2354, 821, 2355, 822, 986, 907, 2811, 1827, 1273, 752, 2060, 1276, 1673, 2531, 236, 259, 1132, 910, 2534, 2358, 912, 2359, 3095, 1904, 1355, 832, 477, 3051, 2278, 1679, 3004, 3129, 2488, 158, 2815, 543, 1686, 1515, 1202, 923, 71, 694, 1371, 1695, 188, 72, 2000, 430, 1144, 1145, 855, 1209, 776, 143, 164, 2093, 2678, 1935, 2980, 2309, 62, 3109, 713, 3159, 2509, 565, 1319, 1943]}}, "Transcriptional regulation by runx3": {"direction": "up", "overlap": {"value": 31, "mean": 12.155339805825244, "std": 7.051829317928235, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 18}}, "setsize": {"value": 46, "mean": 41.550970873786405, "std": 1.9320556056256075, "bin": {"bin_50": 86, "bin_100": 86, "bin_250": 86, "bin_500": 86}}, "score": {"value": 4.013331558935817, "mean": 0.5220991170779611, "std": 1.205315041796802, "bin": {"bin_50": 2.4661764705882354, "bin_100": 3.7703313253012047, "bin_250": 5.457762052189297, "bin_500": 5.310661764705882}}, "pval": {"value": 5.986772807808904e-05, "mean": 0.5409180415581131, "std": 0.3587760476843317, "bin": {"bin_50": 0.3403437958043751, "bin_100": 0.0509823499368979, "bin_250": 4.223330024200185e-05, "bin_500": 1.276282098297127e-07}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 259, 26, 151, 514, 515, 651, 407, 526, 527, 62, 855, 179, 297, 797, 298, 802, 71, 201, 814, 458, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 958, 651, 3022, 201, 797, 1040, 1405, 590, 115, 407, 224, 514, 515, 458, 225, 2524, 370, 802, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 258, 2703, 907, 1273, 2060, 259, 912, 71, 855, 1209, 62, 713]}}, "Acyl chain remodelling of pi": {"direction": "dw", "overlap": {"value": 1, "mean": 0.1635883905013192, "std": 0.3699016477315384, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -3.9898335943434393, "mean": 1.5966786808763922, "std": 1.7707366493054983, "bin": {}}, "pval": {"value": 6.611966626701715e-05, "mean": 0.1201254867919686, "std": 0.1985684847757012, "bin": {}}, "signature_idxs": {"edge": [2877], "full": [2877]}}, "Irs activation": {"direction": "dw", "overlap": {"value": 1, "mean": 0.7142857142857143, "std": 0.4517539514526256, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -3.98012035977634, "mean": -1.0603781131440078, "std": 2.128613521192923, "bin": {}}, "pval": {"value": 6.888038487407044e-05, "mean": 0.1829435172886329, "std": 0.2230807590839303, "bin": {}}, "signature_idxs": {"edge": [2811], "full": [2811]}}, "Signaling by notch": {"direction": "up", "overlap": {"value": 34, "mean": 14.941747572815531, "std": 7.402538586762891, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 17}}, "setsize": {"value": 58, "mean": 58.85679611650485, "std": 3.488034668926816, "bin": {"bin_50": 152, "bin_100": 152, "bin_250": 152, "bin_500": 152}}, "score": {"value": 3.9737142844021647, "mean": 0.4411392402814988, "std": 0.978025139431841, "bin": {"bin_50": 1.3791390728476822, "bin_100": 2.0864093959731544, "bin_250": 2.901526807906261, "bin_500": 2.503595903595904}}, "pval": {"value": 7.076043865605897e-05, "mean": 0.620198315051001, "std": 0.3518651286473304, "bin": {"bin_50": 0.5218033794142342, "bin_100": 0.183470933964733, "bin_250": 0.0039565209563014, "bin_500": 0.00118057337267}}, "signature_idxs": {"edge": [590, 370, 373, 738, 258, 713, 26, 151, 514, 515, 651, 521, 909, 181, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 603, 770, 814, 458, 568, 224, 225, 227, 115, 912], "full": [1088, 568, 26, 1024, 1629, 958, 1798, 651, 3022, 2800, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 1493, 370, 521, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 1351, 603, 2348, 181, 1127, 258, 2703, 907, 909, 2060, 1057, 912, 1280, 2487, 71, 1695, 770, 855, 1209, 1380, 1381, 62, 713, 2030]}}, "Uch proteinases": {"direction": "up", "overlap": {"value": 32, "mean": 12.934466019417476, "std": 7.345038379241775, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 19}}, "setsize": {"value": 48, "mean": 45.69174757281554, "std": 2.489712786954197, "bin": {"bin_50": 79, "bin_100": 79, "bin_250": 79, "bin_500": 79}}, "score": {"value": 3.960299897452599, "mean": 0.4676332859413379, "std": 1.2496925486564852, "bin": {"bin_50": 2.689369658119658, "bin_100": 4.120476973684211, "bin_250": 5.313927077106993, "bin_500": 6.371677105080028}}, "pval": {"value": 7.485569605569786e-05, "mean": 0.5268776688735902, "std": 0.3629400025319104, "bin": {"bin_50": 0.3175327074700926, "bin_100": 0.0413282647695778, "bin_250": 0.0001202222452146, "bin_500": 5.001639240319527e-09}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 26, 151, 514, 515, 444, 651, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 503, 332, 814, 383, 458, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 1392, 958, 651, 2330, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 1499, 526, 297, 527, 151, 814, 298, 179, 332, 258, 907, 2358, 912, 383, 3145, 71, 855, 1209, 2377, 62, 2679, 713, 444, 503]}}, "Regulation of hmox1 expression and activity": {"direction": "up", "overlap": {"value": 32, "mean": 12.524271844660197, "std": 7.335701580194855, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 19}}, "setsize": {"value": 49, "mean": 45.58009708737864, "std": 2.006274620945924, "bin": {"bin_50": 58, "bin_100": 58, "bin_250": 58, "bin_500": 58}}, "score": {"value": 3.9589418401794463, "mean": 0.7171016159839839, "std": 1.1938232298543638, "bin": {"bin_50": 3.687865497076024, "bin_100": 5.7056818181818185, "bin_250": 8.665966386554622, "bin_500": 9.82393876130828}}, "pval": {"value": 7.528256490596519e-05, "mean": 0.514573723238038, "std": 0.3651188593292154, "bin": {"bin_50": 0.2443632781182481, "bin_100": 0.0186371594327644, "bin_250": 1.1306042612128208e-06, "bin_500": 1.3984185607466986e-11}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 26, 151, 514, 515, 651, 181, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 603, 814, 381, 458, 568, 224, 225, 227, 115, 364, 590], "full": [1088, 568, 26, 1024, 1629, 958, 651, 2411, 797, 364, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 603, 181, 1421, 1974, 258, 907, 381, 1057, 1191, 2425, 2358, 912, 3158, 71, 855, 1209, 62, 713]}}, "Metabolism of nucleotides": {"direction": "up", "overlap": {"value": 34, "mean": 13.689320388349516, "std": 8.929637710188212, "bin": {"bin_50": 2, "bin_100": 3, "bin_250": 8, "bin_500": 16}}, "setsize": {"value": 48, "mean": 45.83252427184466, "std": 3.5415166567437466, "bin": {"bin_50": 82, "bin_100": 82, "bin_250": 82, "bin_500": 82}}, "score": {"value": 3.943435665646644, "mean": -1.1184294987896846, "std": 1.2782778290942398, "bin": {"bin_50": 5.354787234042553, "bin_100": 3.9628164556962022, "bin_250": 4.447747747747748, "bin_500": 4.844461209606438}}, "pval": {"value": 8.0322545989997e-05, "mean": 0.354071171489312, "std": 0.3409376828853995, "bin": {"bin_50": 0.0589240460435226, "bin_100": 0.0453414776018772, "bin_250": 0.0008257473825444, "bin_500": 1.7293800949522905e-06}}, "signature_idxs": {"edge": [4, 5, 691, 559, 253, 743, 366, 683, 739, 126, 876, 148, 517, 519, 653, 658, 347, 667, 215, 345, 798, 326, 334, 83, 454, 221, 389, 716, 586, 727, 228, 916, 593, 717], "full": [1547, 126, 83, 716, 717, 454, 148, 653, 876, 326, 658, 253, 221, 1335, 727, 586, 798, 2414, 366, 1246, 1490, 517, 593, 890, 519, 667, 1250, 1177, 3209, 739, 228, 2756, 743, 1424, 683, 334, 916, 691, 5, 1767, 389, 345, 347, 559, 1015, 2311, 4, 215]}}, "Estrogen biosynthesis": {"direction": "dw", "overlap": {"value": 1, "mean": 0.3772609819121447, "std": 0.4847010763747376, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -3.910182842065708, "mean": 0.4853706155859429, "std": 1.7208386185715674, "bin": {}}, "pval": {"value": 9.222628304517144e-05, "mean": 0.2595981981172538, "std": 0.264674537828635, "bin": {}}, "signature_idxs": {"edge": [2824], "full": [2824]}}, "Mapk6 mapk4 signaling": {"direction": "up", "overlap": {"value": 34, "mean": 14.218446601941748, "std": 8.12289402218768, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 16}}, "setsize": {"value": 50, "mean": 48.50728155339806, "std": 1.923903139365317, "bin": {"bin_50": 77, "bin_100": 77, "bin_250": 77, "bin_500": 77}}, "score": {"value": 3.902876788126083, "mean": 0.436374163749397, "std": 1.248358570542089, "bin": {"bin_50": 2.760690789473684, "bin_100": 4.2326858108108105, "bin_250": 5.47132660595619, "bin_500": 5.244269097340317}}, "pval": {"value": 9.50560980976789e-05, "mean": 0.5681669850793678, "std": 0.3688600113322806, "bin": {"bin_50": 0.310874529382391, "bin_100": 0.0387578340752644, "bin_250": 9.829791565332542e-05, "bin_500": 7.104121636929753e-07}}, "signature_idxs": {"edge": [370, 373, 912, 738, 887, 258, 713, 26, 151, 511, 514, 515, 651, 904, 907, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 814, 958, 458, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 1868, 958, 651, 2118, 511, 1403, 797, 1040, 887, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 527, 1661, 151, 814, 298, 179, 904, 258, 986, 907, 2358, 912, 2814, 3129, 71, 855, 1209, 1381, 1310, 62, 713]}}, "Trna modification in the nucleus and cytosol": {"direction": "up", "overlap": {"value": 11, "mean": 4.87378640776699, "std": 3.1712593181757023, "bin": {"bin_50": 3, "bin_100": 3, "bin_250": 6, "bin_500": 12}}, "setsize": {"value": 22, "mean": 13.529126213592232, "std": 4.057430701403474, "bin": {"bin_50": 43, "bin_100": 43, "bin_250": 43, "bin_500": 43}}, "score": {"value": 3.891214493973876, "mean": -0.0554847500599003, "std": 0.8643514445161745, "bin": {"bin_50": 16.478804347826088, "bin_100": 7.85703125, "bin_250": 6.641277641277641, "bin_500": 7.699721226602947}}, "pval": {"value": 9.9743708174449e-05, "mean": 0.5913114818461254, "std": 0.2902092345526449, "bin": {"bin_50": 0.0011246053885867, "bin_100": 0.0082729445560879, "bin_250": 0.0005586365620505, "bin_500": 6.187717333388505e-07}}, "signature_idxs": {"edge": [277, 280, 40, 212, 348, 250, 19, 20, 121, 138, 333], "full": [20, 250, 1481, 40, 333, 19, 1683, 1439, 422, 138, 1207, 697, 1003, 348, 212, 1080, 708, 121, 947, 277, 280, 1321]}}, "Hedgehog on state": {"direction": "up", "overlap": {"value": 30, "mean": 12.5752427184466, "std": 6.636298293339077, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 16}}, "setsize": {"value": 45, "mean": 41.80339805825243, "std": 1.8972867972618663, "bin": {"bin_50": 70, "bin_100": 70, "bin_250": 70, "bin_500": 70}}, "score": {"value": 3.8896839305870015, "mean": 0.5567751925024539, "std": 1.2545866277969462, "bin": {"bin_50": 3.042874396135266, "bin_100": 4.678171641791045, "bin_250": 6.103505041498045, "bin_500": 5.928384816351621}}, "pval": {"value": 0.0001003748678882, "mean": 0.5304257926517765, "std": 0.3643204702561447, "bin": {"bin_50": 0.2870659866655126, "bin_100": 0.0304335118961749, "bin_250": 4.59421185602895e-05, "bin_500": 1.7701110891200142e-07}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 26, 151, 514, 515, 651, 407, 527, 526, 62, 855, 179, 297, 298, 797, 71, 603, 770, 814, 458, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 958, 651, 797, 1040, 3166, 590, 115, 407, 224, 514, 515, 458, 225, 1493, 370, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 603, 258, 907, 1191, 2358, 912, 2364, 71, 770, 855, 1209, 62, 713, 1320]}}, "Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members": {"direction": "up", "overlap": {"value": 0, "mean": 0.6326530612244898, "std": 0.5028034691736702, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.066326530612245, "std": 0.2488520081276979, "bin": {"bin_50": 8, "bin_100": 8, "bin_250": 8, "bin_500": 8}}, "score": {"value": 3.886502739048271, "mean": -0.4607763282070212, "std": 1.7977208649057792, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 2.785570566254671}}, "pval": {"value": 0.0001016987796542, "mean": 0.2835086619905253, "std": 0.2950873384884681, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.3301808657155594}}, "signature_idxs": {"edge": [], "full": [409]}}, "Pou5f1 oct4 sox2 nanog activate genes related to proliferation": {"direction": "up", "overlap": {"value": 0, "mean": 0.6122448979591837, "std": 0.4872382198495233, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 8, "bin_100": 8, "bin_250": 8, "bin_500": 8}}, "score": {"value": 3.886502739048271, "mean": -0.4661242943249048, "std": 1.8204886831846292, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 2.785570566254671}}, "pval": {"value": 0.0001016987796542, "mean": 0.2678588956140034, "std": 0.2838577067199989, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.3301808657155594}}, "signature_idxs": {"edge": [], "full": [409]}}, "Interleukin 10 signaling": {"direction": "up", "overlap": {"value": 0, "mean": 0.6020408163265306, "std": 0.5098978672917954, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 1, "mean": 1.0841836734693877, "std": 0.3122578195272192, "bin": {"bin_50": 6, "bin_100": 6, "bin_250": 6, "bin_500": 6}}, "score": {"value": 3.886502739048271, "mean": -0.3734849670651251, "std": 1.784914580598323, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 3.900603621730382}}, "pval": {"value": 0.0001016987796542, "mean": 0.2923994758532343, "std": 0.2973137888719234, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.2595746201812825}}, "signature_idxs": {"edge": [], "full": [409]}}, "Class i mhc mediated antigen processing presentation": {"direction": "up", "overlap": {"value": 50, "mean": 28.725728155339805, "std": 13.331837148395683, "bin": {"bin_50": 2, "bin_100": 5, "bin_250": 15, "bin_500": 31}}, "setsize": {"value": 123, "mean": 112.89320388349516, "std": 9.797624658989111, "bin": {"bin_50": 295, "bin_100": 295, "bin_250": 295, "bin_500": 295}}, "score": {"value": 3.8840984917446377, "mean": 0.3223458068895866, "std": 1.204887601525433, "bin": {"bin_50": 1.431123375208772, "bin_100": 1.7987894350696991, "bin_250": 2.2228694052728386, "bin_500": 2.3721205632340534}}, "pval": {"value": 0.000102710268923, "mean": 0.6041405327539132, "std": 0.3771461993229535, "bin": {"bin_50": 0.4166947181988512, "bin_100": 0.1588739960757451, "bin_250": 0.0056387008268779, "bin_500": 4.517022194904624e-05}}, "signature_idxs": {"edge": [2, 746, 370, 373, 738, 251, 678, 713, 258, 435, 26, 832, 151, 308, 514, 515, 651, 181, 863, 283, 527, 526, 862, 407, 62, 855, 179, 297, 298, 343, 71, 480, 204, 635, 202, 477, 603, 770, 331, 578, 381, 458, 103, 98, 568, 224, 225, 227, 115, 590], "full": [1022, 283, 1088, 568, 26, 1024, 1629, 1225, 958, 1872, 651, 2189, 874, 1874, 1639, 1172, 98, 963, 578, 2116, 1877, 251, 2259, 797, 1040, 885, 590, 115, 407, 224, 2901, 2125, 514, 515, 458, 225, 1106, 2523, 2996, 370, 373, 1258, 227, 738, 2130, 526, 331, 1346, 297, 202, 1575, 2653, 2654, 527, 678, 2051, 103, 151, 3093, 814, 298, 179, 603, 181, 746, 1744, 258, 3027, 2588, 907, 381, 1131, 1057, 1276, 1191, 1674, 1675, 2425, 2592, 2358, 204, 912, 1356, 832, 477, 1060, 1433, 1358, 308, 1988, 1597, 2910, 480, 1286, 1516, 1364, 1139, 343, 2, 71, 1293, 1526, 770, 2162, 855, 1209, 435, 1149, 2919, 1936, 635, 862, 2844, 2248, 1782, 3120, 3169, 62, 1713, 863, 713, 1388, 1020]}}, "Epigenetic regulation of gene expression": {"direction": "dw", "overlap": {"value": 20, "mean": 19.41747572815534, "std": 7.137381793821183, "bin": {}}, "setsize": {"value": 46, "mean": 42.99514563106796, "std": 4.250639669526318, "bin": {}}, "score": {"value": -3.878364872486032, "mean": -1.2342556202270925, "std": 1.1738716287747466, "bin": {}}, "pval": {"value": 0.0001051609119988, "mean": 0.3568884878092889, "std": 0.3574577146020241, "bin": {}}, "signature_idxs": {"edge": [2926, 3214, 2712, 3108, 2568, 2850, 3004, 2991, 3151, 3150, 2670, 2923, 2745, 2766, 2904, 3056, 2641, 2839, 2840, 3198], "full": [2745, 2926, 3198, 1634, 2324, 2568, 574, 3214, 2850, 1723, 2991, 580, 2123, 1103, 2641, 1404, 1339, 1888, 1259, 1351, 2904, 821, 1353, 2273, 909, 2219, 2359, 1750, 3004, 2766, 2712, 2075, 618, 1695, 1923, 2670, 1926, 3056, 2300, 2839, 2840, 2391, 3108, 3150, 2923, 3151]}}, "Mitochondrial protein import": {"direction": "dw", "overlap": {"value": 20, "mean": 13.468446601941748, "std": 6.078090089851624, "bin": {}}, "setsize": {"value": 35, "mean": 34.5873786407767, "std": 2.2108812815475147, "bin": {}}, "score": {"value": -3.856417827006807, "mean": 1.6025718162972953, "std": 1.8878681708577505, "bin": {}}, "pval": {"value": 0.0001150607521718, "mean": 0.1874419874946837, "std": 0.2901223460226844, "bin": {}}, "signature_idxs": {"edge": [3089, 2801, 2737, 2611, 2699, 2511, 2574, 2456, 2334, 2478, 3146, 3163, 2827, 2886, 2447, 3184, 2451, 3070, 2255, 2400], "full": [2886, 2456, 2255, 1095, 1397, 2400, 1478, 2035, 1331, 2574, 3146, 1728, 1240, 1881, 2334, 2801, 2699, 1495, 1115, 2478, 1274, 1509, 1511, 3070, 2827, 2611, 3163, 2171, 3184, 2737, 2447, 1385, 2511, 2451, 3089]}}, "Tight junction interactions": {"direction": "dw", "overlap": {"value": 1, "mean": 0.7774798927613941, "std": 0.6801096566275604, "bin": {}}, "setsize": {"value": 1, "mean": 1.7024128686327078, "std": 0.7211248073089954, "bin": {}}, "score": {"value": -3.854473335997943, "mean": -0.1063160338286054, "std": 1.5494026024745255, "bin": {}}, "pval": {"value": 0.0001159790220426, "mean": 0.4125569176533025, "std": 0.343800832536018, "bin": {}}, "signature_idxs": {"edge": [2791], "full": [2791]}}, "Signaling by wnt": {"direction": "up", "overlap": {"value": 49, "mean": 23.74757281553398, "std": 11.754956357347504, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 12, "bin_500": 21}}, "setsize": {"value": 90, "mean": 85.60194174757281, "std": 6.374006384893641, "bin": {"bin_50": 213, "bin_100": 213, "bin_250": 213, "bin_500": 213}}, "score": {"value": 3.8259418305721575, "mean": -0.0326762892388985, "std": 0.9981199007700812, "bin": {"bin_50": 0.976316823899371, "bin_100": 1.471279761904762, "bin_250": 2.465722236276246, "bin_500": 2.1797038784067087}}, "pval": {"value": 0.0001302730516183, "mean": 0.6250505086159451, "std": 0.3457491940719926, "bin": {"bin_50": 0.6454652793630864, "bin_100": 0.3420135665639399, "bin_250": 0.0058463148787909, "bin_500": 0.0016959390070549}}, "signature_idxs": {"edge": [748, 1062, 370, 373, 912, 738, 908, 1082, 713, 258, 26, 1057, 151, 514, 515, 444, 651, 181, 909, 1024, 904, 907, 527, 526, 407, 182, 62, 855, 179, 675, 297, 797, 298, 71, 665, 603, 814, 573, 958, 458, 218, 568, 224, 225, 227, 115, 720, 364, 590], "full": [1088, 568, 26, 1024, 1629, 1868, 958, 218, 573, 651, 2635, 2572, 2409, 720, 2897, 1558, 2517, 797, 364, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 665, 1566, 1493, 2524, 370, 1655, 373, 1258, 227, 738, 1259, 2903, 526, 675, 297, 1418, 527, 151, 1969, 814, 298, 179, 1351, 1822, 603, 1504, 904, 2052, 2348, 181, 1421, 1824, 3047, 1127, 258, 748, 907, 908, 909, 1057, 1191, 182, 1592, 2358, 912, 1904, 1062, 2364, 71, 2000, 1454, 855, 1209, 1381, 1617, 2309, 1082, 62, 713, 444, 1317, 2628]}}, "Defective cftr causes cystic fibrosis": {"direction": "up", "overlap": {"value": 29, "mean": 11.91019417475728, "std": 6.270921717387096, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 16}}, "setsize": {"value": 42, "mean": 41.73300970873787, "std": 1.5205957155019303, "bin": {"bin_50": 54, "bin_100": 54, "bin_250": 54, "bin_500": 54}}, "score": {"value": 3.824620740114949, "mean": 0.7347522269055131, "std": 1.1156147917216153, "bin": {"bin_50": 3.967767295597484, "bin_100": 6.1556372549019605, "bin_250": 8.287029288702929, "bin_500": 8.438523695129941}}, "pval": {"value": 0.0001309735480279, "mean": 0.5083451081080875, "std": 0.3576346657028889, "bin": {"bin_50": 0.2295798469686227, "bin_100": 0.0154029461510805, "bin_250": 5.271384236680569e-06, "bin_500": 3.112815609126704e-09}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 26, 151, 514, 515, 651, 407, 526, 527, 62, 676, 855, 179, 297, 797, 298, 71, 814, 458, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 958, 2462, 651, 1875, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 676, 527, 151, 814, 298, 179, 258, 907, 2358, 912, 71, 855, 1209, 3147, 62, 713]}}, "Abc transporter disorders": {"direction": "up", "overlap": {"value": 29, "mean": 11.927184466019416, "std": 6.253118743036628, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 16}}, "setsize": {"value": 42, "mean": 42.31310679611651, "std": 1.9845331695932795, "bin": {"bin_50": 61, "bin_100": 61, "bin_250": 61, "bin_500": 61}}, "score": {"value": 3.824620740114949, "mean": 0.7277639006737601, "std": 1.1074811893524887, "bin": {"bin_50": 3.502430555555556, "bin_100": 5.408943965517241, "bin_250": 7.166398455101384, "bin_500": 7.120700783771323}}, "pval": {"value": 0.0001309735480279, "mean": 0.5118740464528959, "std": 0.3608608076542074, "bin": {"bin_50": 0.2552681350600493, "bin_100": 0.0212914346042941, "bin_250": 1.4820531230257533e-05, "bin_500": 2.1775668041885444e-08}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 26, 151, 514, 515, 651, 407, 527, 526, 62, 676, 855, 179, 297, 797, 298, 71, 814, 458, 568, 224, 225, 227, 115, 590], "full": [1088, 568, 26, 1024, 1629, 958, 2462, 651, 1875, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 526, 297, 676, 527, 151, 814, 298, 179, 258, 907, 2358, 912, 71, 855, 1209, 3147, 62, 713]}}, "Signaling by notch2": {"direction": "dw", "overlap": {"value": 1, "mean": 0.6155717761557178, "std": 0.7337208785180127, "bin": {}}, "setsize": {"value": 1, "mean": 1.9221411192214113, "std": 0.900808660515144, "bin": {}}, "score": {"value": -3.8182301938991454, "mean": 0.5322610754482243, "std": 1.4308991541544014, "bin": {}}, "pval": {"value": 0.0001344124785163, "mean": 0.4179363696503314, "std": 0.3466125562354748, "bin": {}}, "signature_idxs": {"edge": [2703], "full": [2703]}}, "Notch2 intracellular domain regulates transcription": {"direction": "dw", "overlap": {"value": 1, "mean": 0.7327935222672065, "std": 0.5981224756088709, "bin": {}}, "setsize": {"value": 1, "mean": 1.3927125506072875, "std": 0.5357913765209582, "bin": {}}, "score": {"value": -3.8182301938991454, "mean": -0.2242632171291911, "std": 1.701260200708369, "bin": {}}, "pval": {"value": 0.0001344124785163, "mean": 0.3564344380866314, "std": 0.3392929677600036, "bin": {}}, "signature_idxs": {"edge": [2703], "full": [2703]}}, "Arms mediated activation": {"direction": "dw", "overlap": {"value": 1, "mean": 0.7985436893203883, "std": 0.7700068184882701, "bin": {}}, "setsize": {"value": 1, "mean": 1.9393203883495145, "std": 0.7198351512145825, "bin": {}}, "score": {"value": -3.816579091919908, "mean": 0.2381707813782572, "std": 1.2106151575304591, "bin": {}}, "pval": {"value": 0.0001353147131157, "mean": 0.4926946648975806, "std": 0.3206630480098111, "bin": {}}, "signature_idxs": {"edge": [2700], "full": [2700]}}, "Sumoylation of dna damage response and repair proteins": {"direction": "dw", "overlap": {"value": 27, "mean": 14.361650485436892, "std": 7.290290470205936, "bin": {}}, "setsize": {"value": 46, "mean": 43.529126213592235, "std": 4.579039011148904, "bin": {}}, "score": {"value": -3.798328545573349, "mean": -0.4301449231131675, "std": 0.865716172169565, "bin": {}}, "pval": {"value": 0.0001456751453214, "mean": 0.6345117133747565, "std": 0.328082977476346, "bin": {}}, "signature_idxs": {"edge": [2528, 2527, 2931, 3210, 2976, 2805, 2688, 3116, 2969, 3009, 2707, 2702, 2779, 2771, 2773, 2581, 2781, 2782, 2912, 2915, 2906, 2676, 2755, 2562, 2639, 3189, 3063], "full": [1946, 2688, 1556, 2931, 2116, 1099, 2639, 591, 2805, 669, 3063, 802, 2755, 2702, 2527, 2581, 202, 2528, 2136, 3189, 2906, 2707, 2969, 3009, 2434, 2230, 2771, 2912, 1759, 2231, 2437, 2073, 2773, 2915, 2079, 2976, 344, 3210, 2779, 2781, 2782, 2676, 3116, 2306, 2312, 2562]}}, "Synthesis of pe": {"direction": "dw", "overlap": {"value": 1, "mean": 0.7901234567901234, "std": 0.7522156471518984, "bin": {}}, "setsize": {"value": 1, "mean": 2.237037037037037, "std": 0.7653683764793772, "bin": {}}, "score": {"value": -3.75858683987653, "mean": 1.1136905237616417, "std": 1.291303912107451, "bin": {}}, "pval": {"value": 0.0001708757329783, "mean": 0.2852934551021182, "std": 0.2805694594942842, "bin": {}}, "signature_idxs": {"edge": [2739], "full": [2739]}}, "Acyl chain remodelling of ps": {"direction": "dw", "overlap": {"value": 1, "mean": 0.6599496221662469, "std": 0.6003634478400364, "bin": {}}, "setsize": {"value": 1, "mean": 1.3727959697732997, "std": 0.4835484822580718, "bin": {}}, "score": {"value": -3.7419443882589607, "mean": -0.1904732999744472, "std": 1.778072970684161, "bin": {}}, "pval": {"value": 0.0001826019295161, "mean": 0.3190142198116437, "std": 0.3114329884235925, "bin": {}}, "signature_idxs": {"edge": [2728], "full": [2728]}}, "Bicarbonate transporters": {"direction": "up", "overlap": {"value": 0, "mean": 0.4613003095975232, "std": 0.5789556463705147, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.3746130030959751, "std": 0.4840228310807147, "bin": {"bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 3.72631283982667, "mean": 0.8949671679778185, "std": 1.6187147700815585, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0001943012253664, "mean": 0.2945438675971197, "std": 0.2999119980296623, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [566]}}, "Programmed cell death": {"direction": "up", "overlap": {"value": 49, "mean": 24.810679611650485, "std": 12.51748611988162, "bin": {"bin_50": 3, "bin_100": 7, "bin_250": 16, "bin_500": 30}}, "setsize": {"value": 101, "mean": 99.90533980582524, "std": 5.728761589606555, "bin": {"bin_50": 179, "bin_100": 179, "bin_250": 179, "bin_500": 179}}, "score": {"value": 3.722296402440407, "mean": 0.0752454735319569, "std": 1.018486798771118, "bin": {"bin_50": 3.6947875494071143, "bin_100": 4.390482810920122, "bin_250": 4.140046541146605, "bin_500": 4.108156943727414}}, "pval": {"value": 0.0001974190808147, "mean": 0.6272894434318409, "std": 0.3435170341557741, "bin": {"bin_50": 0.0544520008537155, "bin_100": 0.0017508455960622, "bin_250": 7.184080596972841e-06, "bin_500": 2.40487618057277e-09}}, "signature_idxs": {"edge": [370, 14, 373, 738, 251, 166, 713, 258, 26, 535, 151, 514, 515, 516, 414, 651, 43, 863, 527, 526, 407, 409, 62, 855, 179, 297, 797, 672, 298, 802, 71, 663, 78, 460, 83, 814, 719, 230, 102, 458, 568, 224, 225, 356, 227, 115, 268, 270, 590], "full": [1088, 568, 26, 356, 1323, 1024, 78, 1629, 1392, 958, 2930, 651, 2401, 83, 2960, 3022, 719, 1237, 2690, 251, 43, 1883, 1484, 1647, 797, 1040, 3213, 590, 115, 407, 224, 663, 970, 514, 515, 458, 225, 516, 460, 2700, 2524, 1733, 370, 409, 672, 802, 373, 1258, 1497, 227, 738, 2130, 526, 102, 297, 230, 414, 527, 151, 1122, 814, 298, 1579, 179, 2348, 2135, 1269, 1896, 1974, 258, 3026, 2966, 1747, 986, 907, 1827, 535, 2531, 1132, 2140, 1058, 2358, 912, 2277, 1063, 3097, 926, 268, 71, 270, 2609, 855, 1209, 1218, 166, 14, 2740, 62, 863, 713, 1625]}}, "Tlr3 mediated ticam1 dependent programmed cell death": {"direction": "up", "overlap": {"value": 0, "mean": 0.5299684542586751, "std": 0.5862926877627839, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.220820189274448, "std": 0.4147995097432553, "bin": {"bin_50": 5, "bin_100": 5, "bin_250": 5, "bin_500": 5}}, "score": {"value": 3.7146353417893017, "mean": 0.3586090996538792, "std": 1.7599225140297752, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0002034969338455, "mean": 0.3092838847598061, "std": 0.3085027505714975, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [535]}}, "Trp channels": {"direction": "up", "overlap": {"value": 0, "mean": 0.3614864864864865, "std": 0.4874123134789462, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.0405405405405406, "std": 0.1972232367476543, "bin": {"bin_50": 7, "bin_100": 7, "bin_250": 7, "bin_500": 7}}, "score": {"value": 3.7146353417893017, "mean": 0.585961102555105, "std": 1.7405862257273172, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0002034969338455, "mean": 0.2741100668073691, "std": 0.2866619510130199, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [535]}}, "Trif mediated programmed cell death": {"direction": "up", "overlap": {"value": 0, "mean": 0.5299684542586751, "std": 0.5862926877627839, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.220820189274448, "std": 0.4147995097432553, "bin": {"bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 3.7146353417893017, "mean": 0.3586090996538792, "std": 1.7599225140297752, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0002034969338455, "mean": 0.3092838847598061, "std": 0.3085027505714975, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [535]}}, "Beta catenin independent wnt signaling": {"direction": "up", "overlap": {"value": 34, "mean": 14.62864077669903, "std": 7.928102596073744, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 17}}, "setsize": {"value": 59, "mean": 53.63106796116505, "std": 3.656329241145158, "bin": {"bin_50": 117, "bin_100": 117, "bin_250": 117, "bin_500": 117}}, "score": {"value": 3.693028428180324, "mean": 0.2467758551278147, "std": 1.1545689159912884, "bin": {"bin_50": 1.801544540229885, "bin_100": 2.7365679824561404, "bin_250": 3.864368177177413, "bin_500": 3.392224532224532}}, "pval": {"value": 0.0002215992398437, "mean": 0.5921017130101743, "std": 0.3649233327912332, "bin": {"bin_50": 0.4327036796546861, "bin_100": 0.1050203141162522, "bin_250": 0.0005509327657825, "bin_500": 4.991808396626626e-05}}, "signature_idxs": {"edge": [748, 370, 373, 912, 738, 258, 713, 26, 151, 514, 515, 651, 904, 407, 526, 527, 182, 62, 855, 179, 675, 297, 797, 298, 71, 814, 458, 568, 224, 225, 227, 115, 720, 590], "full": [1088, 568, 26, 1024, 1629, 958, 651, 2635, 2572, 2409, 720, 2897, 1558, 2517, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 1493, 2524, 370, 373, 1258, 227, 738, 526, 675, 297, 527, 151, 1969, 814, 298, 179, 1822, 1504, 904, 2052, 1824, 3047, 258, 748, 907, 182, 2358, 912, 71, 2000, 855, 1209, 1381, 62, 713]}}, "Phase ii conjugation of compounds": {"direction": "up", "overlap": {"value": 21, "mean": 8.016990291262136, "std": 4.678208381431926, "bin": {"bin_50": 1, "bin_100": 2, "bin_250": 8, "bin_500": 11}}, "setsize": {"value": 32, "mean": 27.771844660194176, "std": 2.844067833218331, "bin": {"bin_50": 53, "bin_100": 53, "bin_250": 53, "bin_500": 53}}, "score": {"value": 3.665663030480012, "mean": -0.0394450036762533, "std": 0.9498421516045116, "bin": {"bin_50": 4.044471153846154, "bin_100": 4.061451384677582, "bin_250": 7.335555555555556, "bin_500": 5.192920700107559}}, "pval": {"value": 0.0002466985897788, "mean": 0.5856344148145399, "std": 0.3223517668002427, "bin": {"bin_50": 0.225839943305071, "bin_100": 0.0935352604171004, "bin_250": 3.763906323444222e-05, "bin_500": 3.9795614260859775e-05}}, "signature_idxs": {"edge": [277, 128, 249, 710, 446, 41, 650, 649, 187, 523, 170, 171, 174, 804, 74, 666, 796, 771, 223, 774, 588], "full": [2322, 249, 170, 649, 650, 128, 171, 794, 796, 223, 2039, 588, 174, 666, 975, 804, 523, 41, 1751, 2605, 187, 74, 771, 1297, 774, 2302, 2013, 2096, 710, 277, 2105, 446]}}, "Intra golgi and retrograde golgi to er traffic": {"direction": "up", "overlap": {"value": 23, "mean": 23.762135922330096, "std": 8.961715947260837, "bin": {"bin_50": 2, "bin_100": 5, "bin_250": 12, "bin_500": 24}}, "setsize": {"value": 79, "mean": 91.83252427184466, "std": 10.213669235838784, "bin": {"bin_50": 181, "bin_100": 181, "bin_250": 181, "bin_500": 181}}, "score": {"value": 3.643237009172036, "mean": 0.7836914286379623, "std": 1.1120768516172963, "bin": {"bin_50": 2.369665993105908, "bin_100": 2.998367988394584, "bin_250": 2.942232474175108, "bin_500": 3.0769975006046923}}, "pval": {"value": 0.0002692307196547, "mean": 0.5449079285432085, "std": 0.4008074869702365, "bin": {"bin_50": 0.2159364989363957, "bin_100": 0.0313052352005881, "bin_250": 0.001546651585699, "bin_500": 7.517818918205982e-06}}, "signature_idxs": {"edge": [143, 6, 8, 127, 160, 441, 191, 302, 401, 51, 284, 296, 55, 169, 236, 475, 85, 474, 385, 217, 390, 473, 270], "full": [870, 284, 2887, 217, 169, 1229, 647, 1872, 127, 2990, 1641, 401, 1806, 585, 3199, 1251, 85, 1178, 734, 1342, 1811, 8, 465, 1044, 1112, 1817, 296, 896, 1740, 1187, 1121, 900, 819, 2135, 302, 473, 474, 3155, 475, 1975, 1746, 2759, 55, 2589, 608, 236, 1431, 1676, 1903, 1981, 1593, 756, 1280, 160, 1442, 385, 1289, 270, 191, 933, 1929, 143, 1766, 390, 2090, 51, 1860, 1535, 6, 942, 1863, 1311, 441, 2023, 2741, 1715, 1320, 1716, 1322]}}, "Apoptosis": {"direction": "up", "overlap": {"value": 45, "mean": 22.723300970873787, "std": 11.01526481781096, "bin": {"bin_50": 3, "bin_100": 7, "bin_250": 16, "bin_500": 29}}, "setsize": {"value": 91, "mean": 88.14805825242719, "std": 5.029516867347871, "bin": {"bin_50": 159, "bin_100": 159, "bin_250": 159, "bin_500": 159}}, "score": {"value": 3.6403286383020887, "mean": 0.0393529046833614, "std": 1.0330743537895812, "bin": {"bin_50": 4.176839464882943, "bin_100": 4.978189359267734, "bin_250": 4.728719556305763, "bin_500": 4.550959488272921}}, "pval": {"value": 0.0002722902770593, "mean": 0.6051308661069602, "std": 0.3410297528233371, "bin": {"bin_50": 0.0406766799821728, "bin_100": 0.0008804816866067, "bin_250": 1.5217934553876163e-06, "bin_500": 5.782920648147106e-10}}, "signature_idxs": {"edge": [370, 14, 373, 738, 251, 166, 713, 258, 26, 535, 151, 514, 515, 516, 414, 651, 43, 527, 526, 407, 409, 62, 855, 179, 297, 797, 672, 298, 71, 663, 78, 460, 83, 719, 230, 102, 458, 568, 224, 225, 356, 227, 115, 270, 590], "full": [1088, 568, 26, 356, 1323, 1024, 78, 1629, 958, 2930, 651, 83, 2960, 3022, 719, 2690, 251, 43, 1883, 1484, 1647, 797, 1040, 3213, 590, 115, 407, 224, 663, 970, 514, 515, 458, 225, 516, 460, 2700, 2524, 1733, 370, 409, 672, 802, 373, 1258, 1497, 227, 738, 2130, 526, 102, 297, 230, 414, 527, 151, 1122, 814, 298, 1579, 179, 2348, 2135, 1269, 1896, 1974, 258, 3026, 2966, 1747, 986, 907, 1827, 535, 2531, 1132, 1058, 2358, 912, 2277, 3097, 71, 270, 855, 1209, 1218, 166, 14, 2740, 62, 713]}}, "Cytokine signaling in immune system": {"direction": "up", "overlap": {"value": 64, "mean": 40.29368932038835, "std": 16.66208005117109, "bin": {"bin_50": 4, "bin_100": 9, "bin_250": 24, "bin_500": 43}}, "setsize": {"value": 181, "mean": 173.29854368932038, "std": 10.373402219489734, "bin": {"bin_50": 392, "bin_100": 392, "bin_250": 392, "bin_500": 392}}, "score": {"value": 3.610989576104144, "mean": -0.0419239880059683, "std": 0.7729691766579994, "bin": {"bin_50": 2.2357388316151203, "bin_100": 2.5362924281984336, "bin_250": 2.7892080745341614, "bin_500": 2.5316099373405963}}, "pval": {"value": 0.0003050309230383, "mean": 0.7354133819481531, "std": 0.321411905304117, "bin": {"bin_50": 0.118325202454078, "bin_100": 0.0137441166385772, "bin_250": 2.9105795326388583e-05, "bin_500": 4.686120638402441e-07}}, "signature_idxs": {"edge": [587, 359, 135, 370, 372, 686, 373, 10, 15, 251, 256, 678, 713, 258, 26, 304, 436, 151, 514, 515, 516, 651, 41, 521, 657, 181, 403, 534, 527, 526, 407, 409, 62, 179, 296, 297, 298, 672, 669, 343, 71, 215, 665, 65, 81, 115, 202, 477, 603, 582, 84, 335, 102, 458, 103, 568, 219, 224, 225, 227, 597, 116, 590, 141], "full": [1544, 1088, 568, 26, 1024, 1473, 1391, 1629, 2564, 1225, 1227, 958, 1094, 2034, 1797, 2688, 651, 1556, 1726, 1727, 3123, 1877, 3022, 84, 2576, 359, 2993, 2933, 1237, 1238, 219, 2690, 251, 2411, 1804, 2259, 657, 2333, 2639, 582, 403, 2470, 1403, 797, 662, 2260, 1485, 1336, 1040, 3213, 1487, 2900, 587, 1041, 590, 115, 407, 224, 1105, 2125, 514, 515, 458, 225, 516, 2337, 665, 1566, 2805, 370, 669, 372, 1495, 2415, 15, 409, 597, 521, 672, 373, 65, 1258, 227, 738, 2755, 2702, 256, 2903, 526, 1738, 1345, 102, 740, 296, 2527, 297, 2757, 202, 2528, 1264, 527, 1661, 678, 103, 1188, 151, 814, 298, 179, 603, 1266, 2348, 181, 1971, 2136, 41, 304, 1268, 1974, 116, 258, 1745, 3189, 3027, 2058, 1826, 1747, 81, 986, 907, 2811, 335, 1131, 534, 1430, 1275, 1057, 825, 827, 1592, 1058, 2358, 912, 832, 477, 2278, 1196, 135, 2488, 686, 10, 2969, 994, 3009, 2771, 1759, 2231, 2437, 343, 2073, 2773, 71, 2915, 1526, 2079, 855, 141, 1209, 2779, 2781, 2782, 2676, 436, 2306, 1314, 862, 2312, 62, 713, 215, 951]}}, "Abc family proteins mediated transport": {"direction": "up", "overlap": {"value": 32, "mean": 13.317961165048544, "std": 6.603791770344115, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 16}}, "setsize": {"value": 50, "mean": 51.41990291262136, "std": 3.017890343683211, "bin": {"bin_50": 75, "bin_100": 75, "bin_250": 75, "bin_500": 75}}, "score": {"value": 3.606270318335693, "mean": 0.8313343047168666, "std": 1.0258838915302482, "bin": {"bin_50": 2.8358671171171173, "bin_100": 4.351128472222222, "bin_250": 5.638265500190187, "bin_500": 5.423166186089036}}, "pval": {"value": 0.0003106295510477, "mean": 0.503384351224866, "std": 0.3681223740303289, "bin": {"bin_50": 0.3041527321586795, "bin_100": 0.0362722641095339, "bin_250": 7.982976277783394e-05, "bin_500": 4.864632258771835e-07}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 26, 151, 514, 515, 651, 407, 526, 527, 62, 676, 855, 179, 297, 797, 298, 670, 71, 581, 814, 458, 568, 224, 225, 227, 115, 596, 590], "full": [1088, 568, 26, 1024, 1629, 958, 3059, 2462, 651, 1875, 581, 797, 1561, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 2935, 370, 596, 670, 373, 1258, 227, 738, 526, 297, 676, 527, 151, 814, 298, 179, 258, 907, 2358, 912, 2072, 71, 855, 1209, 3147, 1153, 62, 713]}}, "Ncam1 interactions": {"direction": "up", "overlap": {"value": 0, "mean": 0.5384615384615384, "std": 0.4985185152621431, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 15, "bin_100": 15, "bin_250": 15, "bin_500": 15}}, "score": {"value": 3.602045768485033, "mean": -0.173262563988805, "std": 2.260372283959645, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0003157227593777, "mean": 0.1652926438656835, "std": 0.2353838936133575, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [582]}}, "Mapk family signaling cascades": {"direction": "up", "overlap": {"value": 47, "mean": 23.104368932038835, "std": 11.41393630950696, "bin": {"bin_50": 1, "bin_100": 4, "bin_250": 14, "bin_500": 22}}, "setsize": {"value": 98, "mean": 88.2864077669903, "std": 5.588694353030067, "bin": {"bin_50": 212, "bin_100": 212, "bin_250": 212, "bin_500": 212}}, "score": {"value": 3.6001099382725075, "mean": 0.366998662581797, "std": 1.1675181672079205, "bin": {"bin_50": 0.981042654028436, "bin_100": 2.0018218623481783, "bin_250": 2.946127946127946, "bin_500": 2.312870411322424}}, "pval": {"value": 0.000318082664054, "mean": 0.5880023171217027, "std": 0.3704838978698669, "bin": {"bin_50": 0.6437166934391536, "bin_100": 0.150847502981947, "bin_250": 0.0006670230644471, "bin_500": 0.0006735040930602}}, "signature_idxs": {"edge": [722, 370, 373, 912, 738, 887, 258, 713, 884, 26, 304, 509, 151, 511, 514, 515, 516, 651, 904, 188, 527, 526, 407, 62, 855, 179, 297, 53, 797, 298, 71, 665, 201, 115, 603, 582, 814, 458, 568, 224, 122, 225, 227, 597, 116, 549, 590], "full": [1088, 568, 26, 1024, 1629, 1868, 958, 2326, 509, 651, 1726, 2118, 511, 722, 201, 582, 1403, 797, 1959, 2471, 1040, 884, 887, 590, 115, 407, 224, 2040, 514, 515, 458, 225, 516, 53, 665, 1566, 2700, 1493, 1732, 370, 1254, 1179, 2045, 597, 373, 1257, 1258, 227, 738, 526, 1116, 297, 527, 1661, 151, 2207, 814, 298, 179, 603, 1266, 904, 2269, 304, 1896, 116, 258, 986, 907, 1430, 1275, 1191, 2531, 3186, 1592, 2358, 912, 1355, 2814, 3129, 1062, 2367, 71, 188, 1144, 1145, 855, 1209, 549, 1381, 2980, 1310, 62, 713, 122, 2955, 1319, 3141]}}, "Fibronectin matrix formation": {"direction": "dw", "overlap": {"value": 1, "mean": 0.529126213592233, "std": 0.499150942783623, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -3.5974496533804774, "mean": -0.1146519617710351, "std": 1.704512419173626, "bin": {}}, "pval": {"value": 0.0003213526728029, "mean": 0.3012076934077555, "std": 0.2775106508101645, "bin": {}}, "signature_idxs": {"edge": [2576], "full": [2576]}}, "Other semaphorin interactions": {"direction": "dw", "overlap": {"value": 1, "mean": 0.6116504854368932, "std": 0.5257082085701313, "bin": {}}, "setsize": {"value": 1, "mean": 1.1553398058252426, "std": 0.3622283127413132, "bin": {}}, "score": {"value": -3.5974496533804774, "mean": -0.1654587534278987, "std": 1.6126413754189133, "bin": {}}, "pval": {"value": 0.0003213526728029, "mean": 0.3514860627515478, "std": 0.307244835737527, "bin": {}}, "signature_idxs": {"edge": [2576], "full": [2576]}}, "Molecules associated with elastic fibres": {"direction": "dw", "overlap": {"value": 1, "mean": 0.7961165048543689, "std": 0.7221760980008313, "bin": {}}, "setsize": {"value": 1, "mean": 1.7014563106796117, "std": 0.7443625118597235, "bin": {}}, "score": {"value": -3.5974496533804774, "mean": -0.0733900437759364, "std": 1.459988220117193, "bin": {}}, "pval": {"value": 0.0003213526728029, "mean": 0.4001895907250182, "std": 0.3210945228191504, "bin": {}}, "signature_idxs": {"edge": [2576], "full": [2576]}}, "Elastic fibre formation": {"direction": "dw", "overlap": {"value": 1, "mean": 0.7961165048543689, "std": 0.7221760980008313, "bin": {}}, "setsize": {"value": 1, "mean": 1.7014563106796117, "std": 0.7443625118597235, "bin": {}}, "score": {"value": -3.5974496533804774, "mean": -0.0733900437759364, "std": 1.459988220117193, "bin": {}}, "pval": {"value": 0.0003213526728029, "mean": 0.4001895907250182, "std": 0.3210945228191504, "bin": {}}, "signature_idxs": {"edge": [2576], "full": [2576]}}, "Laminin interactions": {"direction": "dw", "overlap": {"value": 1, "mean": 1.1820388349514563, "std": 1.0535965765247446, "bin": {}}, "setsize": {"value": 1, "mean": 2.4514563106796117, "std": 1.2809556564230908, "bin": {}}, "score": {"value": -3.5974496533804774, "mean": -0.1747267989791531, "std": 1.3052071677595742, "bin": {}}, "pval": {"value": 0.0003213526728029, "mean": 0.4408051094089246, "std": 0.3169431262072641, "bin": {}}, "signature_idxs": {"edge": [2576], "full": [2576]}}, "Sumoylation of rna binding proteins": {"direction": "dw", "overlap": {"value": 20, "mean": 11.080097087378642, "std": 5.683897540659047, "bin": {}}, "setsize": {"value": 32, "mean": 31.83252427184466, "std": 2.2627439388728945, "bin": {}}, "score": {"value": -3.570006012516594, "mean": -0.1919874870556263, "std": 0.9298229348189392, "bin": {}}, "pval": {"value": 0.0003569730342651, "mean": 0.649712190416739, "std": 0.3254358140988572, "bin": {}}, "signature_idxs": {"edge": [2528, 2527, 2805, 2688, 3116, 2969, 2885, 3009, 2702, 2779, 2771, 2773, 3124, 2781, 2782, 2915, 2676, 2755, 2639, 3189], "full": [2688, 3124, 2639, 2805, 669, 2755, 2702, 2527, 202, 2528, 1662, 2136, 3189, 2969, 3009, 2434, 2771, 1759, 2231, 2437, 2073, 2773, 2915, 2079, 2779, 2781, 2782, 2676, 3116, 2306, 2312, 2885]}}, "Switching of origins to a post replicative state": {"direction": "up", "overlap": {"value": 35, "mean": 16.810679611650485, "std": 8.560355820358037, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 19}}, "setsize": {"value": 61, "mean": 58.20873786407767, "std": 3.2791073494099976, "bin": {"bin_50": 85, "bin_100": 85, "bin_250": 85, "bin_500": 85}}, "score": {"value": 3.561864163607088, "mean": 0.6859740885709421, "std": 1.198149892515979, "bin": {"bin_50": 2.4957837301587302, "bin_100": 3.816692073170732, "bin_250": 5.53109243697479, "bin_500": 5.7888277345479855}}, "pval": {"value": 0.0003682308999124, "mean": 0.5709255515574044, "std": 0.3860301174542495, "bin": {"bin_50": 0.3371313972628795, "bin_100": 0.049541392930243, "bin_250": 3.812521632033891e-05, "bin_500": 1.831050287115552e-08}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 26, 151, 514, 515, 651, 181, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 603, 814, 381, 458, 570, 568, 731, 224, 225, 227, 115, 269, 590, 589], "full": [1088, 568, 26, 1024, 1629, 958, 1796, 570, 651, 797, 1040, 589, 1489, 590, 115, 407, 224, 514, 515, 458, 225, 2996, 731, 1407, 1252, 370, 373, 1258, 227, 738, 1186, 526, 297, 527, 151, 814, 298, 179, 603, 181, 258, 2588, 907, 381, 1057, 1591, 2358, 912, 71, 269, 855, 1209, 2919, 1156, 2844, 2248, 1782, 3120, 3169, 62, 713]}}, "Mrna editing c to u conversion": {"direction": "dw", "overlap": {"value": 1, "mean": 0.4416666666666666, "std": 0.4965855638479861, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -3.553273480389538, "mean": 0.1586649226440553, "std": 1.786072532928957, "bin": {}}, "pval": {"value": 0.0003804687066946, "mean": 0.2553997816693278, "std": 0.2599718312779485, "bin": {}}, "signature_idxs": {"edge": [2618], "full": [2618]}}, "G2 phase": {"direction": "up", "overlap": {"value": 0, "mean": 0.5313351498637602, "std": 0.6028760447030124, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.2833787465940054, "std": 0.4506386940474773, "bin": {"bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 3.549442631614069, "mean": 0.4672760223164462, "std": 1.4243863373160457, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0003860475719525, "mean": 0.411031358235222, "std": 0.333046937030608, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [589]}}, "Apc c mediated degradation of cell cycle proteins": {"direction": "up", "overlap": {"value": 35, "mean": 16.58009708737864, "std": 8.225929403640711, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 20}}, "setsize": {"value": 59, "mean": 56.25970873786408, "std": 3.549651687085986, "bin": {"bin_50": 81, "bin_100": 81, "bin_250": 81, "bin_500": 81}}, "score": {"value": 3.5451426189008712, "mean": 0.4894986081915347, "std": 1.2134956516570392, "bin": {"bin_50": 2.6216145833333333, "bin_100": 4.014022435897436, "bin_250": 5.845070422535211, "bin_500": 6.610192742986487}}, "pval": {"value": 0.0003924007066546, "mean": 0.5846445085026403, "std": 0.3755323963670207, "bin": {"bin_50": 0.3241278561278478, "bin_100": 0.0439828576930944, "bin_250": 2.492026322250596e-05, "bin_500": 1.1915868350270991e-09}}, "signature_idxs": {"edge": [370, 373, 738, 258, 713, 26, 151, 511, 514, 515, 651, 181, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 323, 814, 381, 458, 568, 224, 225, 726, 227, 115, 269, 590, 589], "full": [1088, 568, 26, 1024, 1629, 1165, 958, 323, 1395, 651, 1955, 511, 726, 797, 1040, 589, 590, 115, 407, 224, 514, 515, 458, 225, 2996, 370, 373, 1258, 227, 738, 526, 1818, 297, 527, 151, 814, 298, 179, 181, 258, 2588, 907, 1130, 381, 1057, 2358, 912, 71, 269, 855, 1209, 2919, 2844, 2248, 1782, 3120, 3169, 62, 713]}}, "Flt3 signaling by cbl mutants": {"direction": "up", "overlap": {"value": 0, "mean": 0.6977777777777778, "std": 0.4592210258876262, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 3.5443346587332702, "mean": -0.8321082659771959, "std": 1.9285436337924715, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0003936052923818, "mean": 0.2244718462282036, "std": 0.2759965777234864, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [587]}}, "Pyrimidine catabolism": {"direction": "up", "overlap": {"value": 0, "mean": 0.44, "std": 0.4963869458396343, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.048, "std": 0.2137662274541982, "bin": {"bin_50": 6, "bin_100": 6, "bin_250": 6, "bin_500": 6}}, "score": {"value": 3.535814531253827, "mean": 0.2112752431633968, "std": 1.8468877359045452, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0004065199903626, "mean": 0.2584251584854782, "std": 0.2796699117492229, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [691]}}, "Sumoylation of chromatin organization proteins": {"direction": "dw", "overlap": {"value": 25, "mean": 11.148058252427184, "std": 6.207568283684575, "bin": {}}, "setsize": {"value": 36, "mean": 34.599514563106794, "std": 2.8747815041129403, "bin": {}}, "score": {"value": -3.5310106910765726, "mean": -0.387582479755537, "std": 0.8509909414976633, "bin": {}}, "pval": {"value": 0.0004139750150831, "mean": 0.6402143361070456, "std": 0.3129766703279643, "bin": {}}, "signature_idxs": {"edge": [2528, 2527, 2931, 2805, 2688, 3116, 2969, 3009, 2702, 2359, 2779, 2771, 2773, 2781, 2474, 2782, 2915, 2676, 2437, 2755, 2434, 2306, 2312, 2639, 3189], "full": [2688, 1556, 2931, 2639, 2805, 669, 2474, 2755, 2702, 2527, 202, 2528, 1351, 2136, 3189, 909, 2359, 2969, 3009, 2434, 2771, 1759, 2231, 2437, 2073, 2773, 2915, 1695, 2079, 2779, 2781, 2782, 2676, 3116, 2306, 2312]}}, "Transport of nucleotide sugars": {"direction": "dw", "overlap": {"value": 1, "mean": 0.1941747572815534, "std": 0.3955640541255021, "bin": {}}, "setsize": {"value": 1, "mean": 1.0145631067961165, "std": 0.1197957541675055, "bin": {}}, "score": {"value": -3.527681469365644, "mean": 1.506134463478804, "std": 1.9432557538988255, "bin": {}}, "pval": {"value": 0.0004192162958851, "mean": 0.116432399816558, "std": 0.1948415235748172, "bin": {}}, "signature_idxs": {"edge": [2605], "full": [2605]}}, "The canonical retinoid cycle in rods twilight vision": {"direction": "dw", "overlap": {"value": 1, "mean": 0.5456790123456791, "std": 0.5268235543906071, "bin": {}}, "setsize": {"value": 1, "mean": 1.1530864197530863, "std": 0.360070781708636, "bin": {}}, "score": {"value": -3.525972567382261, "mean": -0.0351673417829888, "std": 1.7773554679808734, "bin": {}}, "pval": {"value": 0.0004219306715214, "mean": 0.2836298087208782, "std": 0.2745654176063696, "bin": {}}, "signature_idxs": {"edge": [2606], "full": [2606]}}, "Copi independent golgi to er retrograde traffic": {"direction": "up", "overlap": {"value": 11, "mean": 8.053398058252426, "std": 3.9403394347399954, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 5, "bin_500": 11}}, "setsize": {"value": 26, "mean": 27.12135922330097, "std": 2.2597856451930913, "bin": {"bin_50": 45, "bin_100": 45, "bin_250": 45, "bin_500": 45}}, "score": {"value": 3.503372870770467, "mean": 0.302798844042666, "std": 0.8982376608905671, "bin": {"bin_50": 4.783617424242424, "bin_100": 2.331400742115028, "bin_250": 5.096707818930041, "bin_500": 6.420099045778476}}, "pval": {"value": 0.0004594058884168, "mean": 0.6258770271233919, "std": 0.3350370934950194, "bin": {"bin_50": 0.1952735388158895, "bin_100": 0.3559802976275766, "bin_250": 0.0045172618985585, "bin_500": 7.556788765224261e-06}}, "signature_idxs": {"edge": [143, 8, 302, 401, 127, 473, 236, 465, 270, 296, 169], "full": [169, 127, 401, 1342, 8, 465, 296, 1121, 2135, 302, 473, 1975, 2589, 608, 236, 1431, 1676, 1593, 756, 270, 143, 1860, 1535, 942, 2023, 1322]}}, "Runx3 regulates wnt signaling": {"direction": "dw", "overlap": {"value": 1, "mean": 0.5558252427184466, "std": 0.5160436202527668, "bin": {}}, "setsize": {"value": 1, "mean": 1.016990291262136, "std": 0.1292347525434382, "bin": {}}, "score": {"value": -3.476262941423508, "mean": -0.1758704449268936, "std": 1.492672453709892, "bin": {}}, "pval": {"value": 0.0005084535134627, "mean": 0.3648754910929673, "std": 0.2929594667005114, "bin": {}}, "signature_idxs": {"edge": [2524], "full": [2524]}}, "Binding of tcf lef ctnnb1 to target gene promoters": {"direction": "dw", "overlap": {"value": 1, "mean": 0.5558252427184466, "std": 0.5160436202527668, "bin": {}}, "setsize": {"value": 1, "mean": 1.016990291262136, "std": 0.1292347525434382, "bin": {}}, "score": {"value": -3.476262941423508, "mean": -0.1758704449268936, "std": 1.492672453709892, "bin": {}}, "pval": {"value": 0.0005084535134627, "mean": 0.3648754910929673, "std": 0.2929594667005114, "bin": {}}, "signature_idxs": {"edge": [2524], "full": [2524]}}, "Lrr flii interacting protein 1 lrrfip1 activates type i ifn production": {"direction": "dw", "overlap": {"value": 1, "mean": 0.6577669902912622, "std": 0.6437623514340921, "bin": {}}, "setsize": {"value": 1, "mean": 1.2572815533980584, "std": 0.5322788417623588, "bin": {}}, "score": {"value": -3.476262941423508, "mean": -0.1499363091283954, "std": 1.4208326152525113, "bin": {}}, "pval": {"value": 0.0005084535134627, "mean": 0.4149717057630105, "std": 0.313009049991205, "bin": {}}, "signature_idxs": {"edge": [2524], "full": [2524]}}, "Sumoylation of ubiquitinylation proteins": {"direction": "dw", "overlap": {"value": 19, "mean": 9.449029126213592, "std": 5.461233548653461, "bin": {}}, "setsize": {"value": 30, "mean": 27.453883495145632, "std": 1.7873094890722168, "bin": {}}, "score": {"value": -3.4686612467277445, "mean": -0.1572884084685554, "std": 0.9014772608467888, "bin": {}}, "pval": {"value": 0.0005230585328344, "mean": 0.6545901700997189, "std": 0.3239621676727282, "bin": {}}, "signature_idxs": {"edge": [2528, 2527, 2931, 2805, 2688, 2694, 2969, 3009, 2702, 2779, 2771, 2773, 2781, 2782, 2915, 2676, 2755, 2639, 3189], "full": [2688, 1556, 2931, 2639, 2694, 2805, 669, 2755, 2702, 2527, 202, 2528, 2136, 3189, 2969, 3009, 2771, 1759, 2231, 2437, 2073, 2773, 2915, 2079, 2779, 2781, 2782, 2676, 2306, 2312]}}, "Er quality control compartment erqc": {"direction": "dw", "overlap": {"value": 1, "mean": 1.0606796116504855, "std": 0.95210932118493, "bin": {}}, "setsize": {"value": 1, "mean": 2.9635922330097086, "std": 1.2251945392339945, "bin": {}}, "score": {"value": -3.460775944988306, "mean": 0.5833647682671571, "std": 1.1415139733942834, "bin": {}}, "pval": {"value": 0.0005386208970388, "mean": 0.4456356260955993, "std": 0.3344847203664676, "bin": {}}, "signature_idxs": {"edge": [2559], "full": [2559]}}, "Attachment and entry": {"direction": "up", "overlap": {"value": 0, "mean": 0.7888349514563107, "std": 0.4368594916874587, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.046116504854369, "std": 0.2703996790431137, "bin": {"bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 3.453582973196617, "mean": -0.8106089343366657, "std": 1.3719991493195605, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0005531920979384, "mean": 0.3300673788846759, "std": 0.286268988264632, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [676]}}, "Sumoylation of dna replication proteins": {"direction": "dw", "overlap": {"value": 21, "mean": 11.87864077669903, "std": 6.042714468888302, "bin": {}}, "setsize": {"value": 35, "mean": 34.529126213592235, "std": 2.1056157491572995, "bin": {}}, "score": {"value": -3.426768104512789, "mean": -0.4394927336061675, "std": 0.8592766121011057, "bin": {}}, "pval": {"value": 0.0006108104522892, "mean": 0.6339198960271976, "std": 0.3172919285231038, "bin": {}}, "signature_idxs": {"edge": [2528, 2527, 2805, 2688, 2969, 2881, 3009, 2702, 2779, 2771, 2994, 2773, 2781, 2782, 2915, 2676, 2755, 3048, 2639, 3040, 3189], "full": [1165, 2688, 2994, 3040, 252, 2639, 2805, 669, 1109, 2755, 2702, 2527, 202, 2528, 2136, 3048, 3189, 2282, 2969, 3009, 2771, 1759, 2231, 2437, 2073, 2773, 2915, 2079, 2779, 2781, 2782, 2676, 2881, 2306, 2312]}}, "Transport of mature mrnas derived from intronless transcripts": {"direction": "dw", "overlap": {"value": 21, "mean": 12.485436893203884, "std": 6.764935404179153, "bin": {}}, "setsize": {"value": 35, "mean": 36.21116504854369, "std": 1.6521746780936135, "bin": {}}, "score": {"value": -3.4245012728702253, "mean": -0.3550698997053867, "std": 0.8812161356906153, "bin": {}}, "pval": {"value": 0.0006159289594118, "mean": 0.6571229286016341, "std": 0.3228743985516816, "bin": {}}, "signature_idxs": {"edge": [2528, 2527, 2805, 2621, 2688, 2969, 2884, 3009, 2702, 2779, 2771, 2773, 2781, 2782, 2915, 2775, 2676, 2657, 2755, 2639, 3189], "full": [2688, 359, 2639, 2805, 669, 2755, 2702, 1964, 2527, 202, 2528, 2136, 2355, 2657, 3189, 2969, 3009, 2771, 1759, 2231, 2437, 2073, 2773, 2915, 2775, 2079, 2779, 2781, 2782, 2676, 2306, 2884, 2621, 1623, 2312]}}, "Fatty acid metabolism": {"direction": "dw", "overlap": {"value": 23, "mean": 12.601941747572816, "std": 6.622394788478767, "bin": {}}, "setsize": {"value": 53, "mean": 56.89320388349515, "std": 4.797678689021568, "bin": {}}, "score": {"value": -3.402040564954585, "mean": -0.6410370109047604, "std": 1.3258270224785833, "bin": {}}, "pval": {"value": 0.0006688470929181, "mean": 0.354277511640737, "std": 0.3264233172937892, "bin": {}}, "signature_idxs": {"edge": [3201, 2798, 3076, 2416, 2803, 2484, 2490, 2809, 2684, 2571, 2579, 2857, 3138, 2746, 2545, 2658, 2638, 3183, 2944, 2643, 2521, 2650, 2843], "full": [247, 2746, 3076, 2684, 2033, 1394, 2113, 961, 2571, 1801, 2798, 1399, 1035, 966, 2638, 1174, 2579, 2521, 2643, 2803, 1650, 1652, 1656, 892, 2416, 1497, 2265, 3201, 2857, 2650, 2131, 2132, 1117, 1966, 2809, 2658, 2484, 830, 1982, 1752, 2490, 2944, 2545, 3138, 1845, 1694, 1300, 2388, 3183, 2843, 2021, 2317, 1472]}}, "Rrna modification in the nucleus and cytosol": {"direction": "dw", "overlap": {"value": 39, "mean": 28.45631067961165, "std": 9.286985045927665, "bin": {}}, "setsize": {"value": 56, "mean": 54.34466019417476, "std": 2.651734298048095, "bin": {}}, "score": {"value": -3.3971016292548524, "mean": -1.5049432386646604, "std": 1.3675746480917093, "bin": {}}, "pval": {"value": 0.000681036687647, "mean": 0.3185351385207093, "std": 0.3550565174366032, "bin": {}}, "signature_idxs": {"edge": [2929, 2731, 2732, 3079, 2802, 2714, 2243, 2685, 2873, 2250, 2390, 2508, 2885, 3135, 2185, 3136, 2458, 3003, 2585, 2208, 2784, 2204, 2787, 3144, 3039, 2298, 2911, 2304, 2683, 3055, 2315, 2427, 3050, 2442, 2826, 3185, 3073, 2647, 2954], "full": [1089, 3185, 2185, 2685, 1029, 2929, 2458, 3144, 405, 2802, 2647, 803, 2204, 104, 901, 416, 2208, 2585, 1976, 3050, 3079, 2427, 3003, 1837, 2911, 2714, 2826, 3055, 2157, 2873, 1006, 2298, 2784, 2442, 3073, 2731, 2732, 495, 2304, 2243, 2390, 3039, 1013, 350, 2787, 3135, 277, 1940, 2954, 2508, 2315, 2885, 2029, 3136, 2683, 2250]}}, "Antigen processing cross presentation": {"direction": "up", "overlap": {"value": 30, "mean": 13.364077669902912, "std": 6.483621701094183, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 18}}, "setsize": {"value": 49, "mean": 51.03883495145631, "std": 2.525298521609755, "bin": {"bin_50": 77, "bin_100": 77, "bin_250": 77, "bin_500": 77}}, "score": {"value": 3.3938112598307324, "mean": 0.6606344305939695, "std": 1.0422529083240153, "bin": {"bin_50": 2.760690789473684, "bin_100": 4.2326858108108105, "bin_250": 5.47132660595619, "bin_500": 6.126483050847457}}, "pval": {"value": 0.0006892717940809, "mean": 0.5456453275819227, "std": 0.3659829171921698, "bin": {"bin_50": 0.310874529382391, "bin_100": 0.0387578340752644, "bin_250": 9.829791565332542e-05, "bin_500": 2.0605428416112048e-08}}, "signature_idxs": {"edge": [370, 373, 738, 251, 258, 713, 26, 151, 514, 515, 651, 283, 407, 526, 527, 62, 855, 179, 297, 797, 298, 71, 814, 458, 568, 224, 225, 227, 115, 590], "full": [283, 1088, 568, 26, 1024, 1629, 1225, 958, 1872, 651, 1877, 251, 2259, 797, 1040, 590, 115, 407, 224, 2901, 514, 515, 458, 225, 2523, 370, 373, 1258, 227, 738, 526, 297, 2653, 527, 151, 3093, 814, 298, 179, 258, 3027, 907, 2358, 912, 71, 855, 1209, 62, 713]}}, "Transcriptional regulation by small rnas": {"direction": "dw", "overlap": {"value": 20, "mean": 11.655339805825244, "std": 6.260730255420205, "bin": {}}, "setsize": {"value": 37, "mean": 37.407766990291265, "std": 1.997264601261948, "bin": {}}, "score": {"value": -3.3929546515126363, "mean": -0.3972224310921288, "std": 0.7366690231446658, "bin": {}}, "pval": {"value": 0.0006914308386671, "mean": 0.6649673755290503, "std": 0.2975390166504904, "bin": {}}, "signature_idxs": {"edge": [2528, 2527, 2805, 2688, 2969, 2698, 3009, 2702, 2779, 2771, 2773, 2781, 2782, 2915, 2676, 2904, 2755, 2639, 2641, 3189], "full": [1869, 1474, 2688, 2639, 2038, 2641, 2698, 2338, 2805, 669, 2755, 2702, 2527, 202, 2528, 1663, 1351, 983, 2904, 2136, 3189, 2969, 3009, 2771, 1759, 2231, 2437, 2073, 2773, 2915, 2079, 2779, 2781, 2782, 2676, 2306, 2312]}}, "Viral messenger rna synthesis": {"direction": "dw", "overlap": {"value": 20, "mean": 11.220873786407768, "std": 6.355736741539839, "bin": {}}, "setsize": {"value": 35, "mean": 34.41747572815534, "std": 2.2908609982905, "bin": {}}, "score": {"value": -3.3909984347929103, "mean": -0.2632815055090717, "std": 0.7751584621286535, "bin": {}}, "pval": {"value": 0.0006963849882732, "mean": 0.7082888325200691, "std": 0.3017066758535532, "bin": {}}, "signature_idxs": {"edge": [2528, 2527, 2805, 2688, 2969, 2698, 3009, 2702, 2779, 2771, 2773, 2781, 2782, 2915, 2676, 2904, 2755, 2639, 2641, 3189], "full": [1474, 2688, 2639, 659, 2038, 2641, 2698, 2338, 2805, 669, 2755, 2702, 2527, 202, 2528, 1663, 2904, 2136, 3189, 2969, 3009, 2771, 1759, 2231, 2437, 2073, 2773, 2915, 2079, 2779, 2781, 2782, 2676, 2306, 2312]}}, "Cytoprotection by hmox1": {"direction": "up", "overlap": {"value": 29, "mean": 15.264563106796116, "std": 6.884300879212943, "bin": {"bin_50": 1, "bin_100": 4, "bin_250": 11, "bin_500": 21}}, "setsize": {"value": 68, "mean": 64.83495145631068, "std": 3.5957015529431366, "bin": {"bin_50": 110, "bin_100": 110, "bin_250": 110, "bin_500": 110}}, "score": {"value": 3.3850631938809506, "mean": 0.939000341067099, "std": 1.0482386655891682, "bin": {"bin_50": 1.918577981651376, "bin_100": 3.968619662363456, "bin_250": 4.617440225035161, "bin_500": 4.753232987068052}}, "pval": {"value": 0.0007116186950901, "mean": 0.4699320360831873, "std": 0.3835416044430508, "bin": {"bin_50": 0.4130249240673272, "bin_100": 0.0220749431150344, "bin_250": 7.19882924399478e-05, "bin_500": 6.232758314862519e-08}}, "signature_idxs": {"edge": [370, 373, 258, 713, 26, 151, 514, 515, 181, 407, 526, 409, 527, 62, 179, 297, 298, 71, 79, 603, 381, 458, 568, 224, 225, 227, 115, 364, 590], "full": [1088, 568, 26, 2927, 1024, 1629, 958, 1167, 1798, 651, 1555, 1235, 2411, 2332, 2898, 2122, 797, 364, 1040, 1562, 590, 115, 407, 224, 514, 515, 458, 225, 79, 2753, 370, 409, 2525, 373, 1258, 227, 738, 526, 1739, 297, 527, 151, 814, 298, 179, 603, 181, 1421, 1974, 258, 907, 381, 1057, 1191, 2425, 2358, 912, 1679, 1202, 3158, 71, 2670, 855, 1209, 2164, 62, 713, 3058]}}, "Cilium assembly": {"direction": "up", "overlap": {"value": 21, "mean": 17.691747572815533, "std": 8.208427462797529, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 3, "bin_500": 12}}, "setsize": {"value": 55, "mean": 60.07281553398058, "std": 7.176657065505861, "bin": {"bin_50": 183, "bin_100": 183, "bin_250": 183, "bin_500": 183}}, "score": {"value": 3.3814938657444, "mean": 0.7163847705434252, "std": 1.1196611241046792, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.6644897959183673, "bin_500": 1.375640747960436}}, "pval": {"value": 0.0007209284246978, "mean": 0.5030560453085753, "std": 0.3669144822823486, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.8268643709953708, "bin_500": 0.1841895794805187}}, "signature_idxs": {"edge": [143, 127, 538, 434, 511, 702, 302, 401, 530, 402, 621, 294, 608, 665, 662, 236, 585, 376, 466, 270, 281], "full": [1090, 2989, 127, 1097, 401, 511, 402, 1237, 1403, 662, 585, 665, 730, 1108, 1342, 294, 466, 376, 895, 1818, 1501, 1121, 1122, 1579, 2135, 302, 530, 2478, 2589, 608, 236, 1748, 1431, 1676, 1678, 1833, 538, 1515, 1287, 1995, 1849, 1289, 1525, 621, 270, 2003, 143, 434, 2089, 702, 1774, 1777, 1465, 1320, 281]}}, "Dna strand elongation": {"direction": "up", "overlap": {"value": 14, "mean": 8.29126213592233, "std": 4.847441659269622, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 4, "bin_500": 10}}, "setsize": {"value": 27, "mean": 27.77912621359223, "std": 2.424040439438107, "bin": {"bin_50": 35, "bin_100": 35, "bin_250": 35, "bin_500": 35}}, "score": {"value": 3.377719181895367, "mean": -0.0601217410983142, "std": 0.8611698692996907, "bin": {"bin_50": 6.196691176470588, "bin_100": 3.020108043217287, "bin_250": 5.244315177154944, "bin_500": 7.928688524590164}}, "pval": {"value": 0.0007308967900725, "mean": 0.6295538041103502, "std": 0.3086752803551498, "bin": {"bin_50": 0.1553991536419083, "bin_100": 0.2897038292296705, "bin_250": 0.0098961463934591, "bin_500": 4.291398133266999e-06}}, "signature_idxs": {"edge": [369, 737, 731, 252, 130, 131, 329, 21, 729, 119, 260, 292, 271, 591], "full": [1482, 252, 1242, 1104, 1489, 591, 729, 731, 1407, 1252, 21, 329, 369, 2043, 130, 292, 1496, 805, 737, 131, 1186, 260, 1591, 990, 271, 119, 2790]}}, "Protein localization": {"direction": "dw", "overlap": {"value": 32, "mean": 25.97087378640777, "std": 10.717199959161563, "bin": {}}, "setsize": {"value": 67, "mean": 74.18203883495146, "std": 6.26233677332747, "bin": {}}, "score": {"value": -3.3555688545962465, "mean": 1.5594110758345356, "std": 2.0947329132902324, "bin": {}}, "pval": {"value": 0.000792019377537, "mean": 0.2555609300308859, "std": 0.3569924888492793, "bin": {}}, "signature_idxs": {"edge": [3202, 3089, 2411, 2935, 2801, 2737, 2611, 2484, 2684, 2500, 2699, 2511, 2574, 2456, 2334, 2323, 2478, 3146, 3163, 2432, 2827, 2886, 2447, 2513, 2643, 3184, 2653, 2650, 2451, 3070, 2526, 2400], "full": [2513, 2684, 2886, 2323, 2456, 2111, 871, 1394, 2255, 1095, 1169, 1397, 2400, 1478, 961, 2035, 575, 1331, 2574, 3146, 1728, 1035, 2411, 1240, 1881, 2334, 583, 2801, 2643, 2699, 2935, 1341, 1495, 596, 1570, 2526, 87, 1115, 2650, 2131, 2653, 2478, 3202, 55, 1274, 2484, 1509, 1511, 3070, 2432, 2500, 2827, 1918, 1921, 2611, 3163, 2171, 3184, 2737, 1937, 2021, 2447, 1385, 2105, 2511, 2451, 3089]}}, "Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand": {"direction": "up", "overlap": {"value": 18, "mean": 10.99514563106796, "std": 6.479989791445523, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 5, "bin_500": 10}}, "setsize": {"value": 31, "mean": 30.575242718446603, "std": 1.8065868396091345, "bin": {"bin_50": 47, "bin_100": 47, "bin_250": 47, "bin_500": 47}}, "score": {"value": 3.339984742133975, "mean": 0.1584518755541417, "std": 1.0359782039154073, "bin": {"bin_50": 4.574728260869565, "bin_100": 2.229591836734694, "bin_250": 4.853027630805409, "bin_500": 5.350575985821887}}, "pval": {"value": 0.0008378299284967, "mean": 0.6126046167689052, "std": 0.3387863879536805, "bin": {"bin_50": 0.2030241760545403, "bin_100": 0.3684815592825167, "bin_250": 0.00545325875553, "bin_500": 7.132919056420002e-05}}, "signature_idxs": {"edge": [143, 608, 800, 8, 942, 657, 533, 302, 401, 682, 127, 887, 236, 465, 270, 830, 296, 169], "full": [169, 1328, 127, 401, 1237, 878, 1239, 657, 887, 800, 1249, 8, 465, 296, 979, 1121, 2135, 302, 682, 2589, 533, 608, 236, 1431, 1676, 830, 270, 143, 942, 2023, 1322]}}, "Androgen biosynthesis": {"direction": "dw", "overlap": {"value": 1, "mean": 0.2645631067961165, "std": 0.4411002939451562, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -3.335843219440104, "mean": 1.1075298957431323, "std": 1.8933465515216856, "bin": {}}, "pval": {"value": 0.0008504110805271, "mean": 0.1756421194716174, "std": 0.2437268050599615, "bin": {}}, "signature_idxs": {"edge": [2490], "full": [2490]}}, "Mecp2 regulates transcription factors": {"direction": "dw", "overlap": {"value": 1, "mean": 0.7543859649122807, "std": 0.4419421268812122, "bin": {}}, "setsize": {"value": 1, "mean": 1.0651629072681703, "std": 0.2468130928142392, "bin": {}}, "score": {"value": -3.304318110998802, "mean": -0.9821656353327018, "std": 1.662506185432635, "bin": {}}, "pval": {"value": 0.0009520773343094, "mean": 0.2451761292150782, "std": 0.2750147578827311, "bin": {}}, "signature_idxs": {"edge": [2418], "full": [2418]}}, "Abacavir metabolism": {"direction": "up", "overlap": {"value": 0, "mean": 0.5753086419753086, "std": 0.4942960736682366, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 3.302476037001332, "mean": -0.3627051307349936, "std": 1.9097090413989584, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0009583527600067, "mean": 0.2417491216568803, "std": 0.2661711942359496, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [739]}}, "Abacavir transport and metabolism": {"direction": "up", "overlap": {"value": 0, "mean": 0.5266990291262136, "std": 0.6622745278154915, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.966019417475728, "std": 0.1811792000633157, "bin": {"bin_50": 6, "bin_100": 6, "bin_250": 6, "bin_500": 6}}, "score": {"value": 3.302476037001332, "mean": 0.5905762185229235, "std": 1.420406344678547, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0009583527600067, "mean": 0.399026364279542, "std": 0.3173841993437442, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [739]}}, "Nuclear import of rev protein": {"direction": "dw", "overlap": {"value": 18, "mean": 10.604368932038836, "std": 5.891105714846815, "bin": {}}, "setsize": {"value": 31, "mean": 30.50728155339806, "std": 1.1564279570110754, "bin": {}}, "score": {"value": -3.300600424005083, "mean": -0.2662730785997009, "std": 0.8169660660518107, "bin": {}}, "pval": {"value": 0.0009647817893612, "mean": 0.6871544752103023, "std": 0.308961068837417, "bin": {}}, "signature_idxs": {"edge": [2688, 2528, 2527, 2781, 2782, 2969, 3176, 2915, 2639, 3009, 2805, 2702, 3189, 2676, 2779, 2771, 2773, 2755], "full": [2688, 3176, 2639, 1560, 2805, 669, 2755, 2702, 2527, 202, 2528, 983, 2136, 3189, 1058, 2969, 3009, 2771, 1759, 2231, 2437, 2073, 2773, 2915, 2079, 2779, 2781, 2782, 2676, 2306, 2312]}}, "Infectious disease": {"direction": "up", "overlap": {"value": 146, "mean": 93.33495145631068, "std": 35.34489487789831, "bin": {"bin_50": 5, "bin_100": 9, "bin_250": 34, "bin_500": 72}}, "setsize": {"value": 349, "mean": 341.3398058252427, "std": 20.86156562558634, "bin": {"bin_50": 619, "bin_100": 619, "bin_250": 619, "bin_500": 619}}, "score": {"value": 3.3001249194299827, "mean": -0.4428814065868994, "std": 0.8677237015289705, "bin": {"bin_50": 1.764324844536571, "bin_100": 1.5552459016393445, "bin_250": 2.54287083632878, "bin_500": 2.827509848855473}}, "pval": {"value": 0.000966418008802, "mean": 0.6180619101849218, "std": 0.3379145639376117, "bin": {"bin_50": 0.1745931703479176, "bin_100": 0.1462452764497185, "bin_250": 6.283864460628401e-06, "bin_500": 2.4332908978241464e-12}}, "signature_idxs": {"edge": [0, 564, 565, 513, 26, 535, 31, 514, 515, 34, 516, 529, 527, 526, 48, 62, 618, 617, 71, 604, 605, 603, 86, 84, 580, 574, 107, 102, 568, 602, 104, 115, 601, 590, 143, 587, 682, 681, 130, 680, 133, 167, 713, 151, 150, 679, 153, 677, 651, 659, 181, 180, 676, 179, 656, 675, 169, 669, 201, 202, 236, 784, 241, 219, 220, 224, 225, 226, 227, 727, 725, 268, 721, 270, 730, 253, 738, 258, 843, 304, 832, 852, 302, 300, 861, 855, 830, 297, 298, 299, 293, 797, 803, 799, 793, 352, 790, 818, 826, 821, 817, 815, 814, 813, 812, 816, 379, 926, 378, 388, 391, 916, 362, 946, 912, 370, 373, 431, 883, 437, 878, 909, 905, 401, 904, 903, 405, 902, 407, 402, 901, 907, 899, 416, 412, 477, 460, 456, 457, 458, 461, 468, 471, 469, 470, 464], "full": [2745, 1088, 568, 26, 2452, 3121, 1163, 2926, 1024, 1473, 1391, 1629, 1868, 1166, 1717, 790, 1474, 1026, 169, 958, 1549, 959, 2325, 2633, 2257, 1798, 574, 1232, 3214, 2958, 2688, 651, 1723, 2635, 2572, 580, 793, 401, 1877, 2407, 1952, 1802, 2896, 1953, 2408, 3091, 84, 2576, 1955, 1400, 3176, 402, 1237, 1238, 219, 878, 721, 1958, 656, 1558, 2411, 1099, 220, 1881, 2334, 253, 2639, 201, 1645, 883, 725, 1483, 659, 2751, 2694, 405, 34, 1403, 2695, 797, 1103, 2412, 1038, 362, 456, 1560, 1104, 1485, 2038, 2641, 1404, 1336, 1960, 1040, 727, 2039, 587, 1962, 3042, 513, 2698, 1247, 590, 115, 407, 224, 457, 799, 2901, 2125, 514, 515, 458, 225, 516, 1042, 460, 2338, 461, 730, 973, 2524, 1494, 1568, 2805, 370, 1179, 1255, 669, 2806, 1409, 2127, 130, 1654, 0, 86, 1810, 373, 1109, 974, 894, 226, 464, 803, 293, 2701, 3043, 150, 1258, 1571, 227, 738, 2755, 2702, 1259, 2202, 1113, 412, 1261, 526, 1345, 102, 1964, 2527, 675, 2346, 297, 676, 2582, 202, 1049, 2528, 677, 468, 527, 1661, 1577, 812, 899, 151, 1189, 813, 1578, 2999, 469, 1662, 104, 814, 298, 982, 601, 470, 901, 471, 815, 816, 679, 902, 179, 299, 1663, 817, 818, 416, 1351, 983, 1123, 180, 48, 903, 602, 1420, 680, 1822, 2904, 603, 1504, 681, 300, 1124, 133, 604, 605, 31, 1266, 904, 2052, 1125, 2135, 2810, 181, 529, 302, 378, 2136, 379, 1050, 3154, 153, 1824, 1666, 304, 682, 905, 1896, 258, 1128, 1270, 821, 2355, 1899, 3189, 2270, 986, 907, 3167, 1671, 2273, 2589, 1827, 535, 909, 1191, 1977, 236, 2425, 1676, 826, 2357, 2219, 1058, 2358, 912, 2359, 830, 832, 477, 3004, 2488, 916, 2766, 2969, 2365, 3009, 3104, 1601, 2712, 843, 2771, 1759, 2231, 2437, 2073, 2773, 926, 2291, 268, 617, 2075, 71, 2915, 1371, 618, 1695, 3140, 1526, 2000, 2079, 1762, 270, 2609, 852, 388, 855, 1209, 2779, 1378, 241, 431, 107, 1856, 2781, 143, 2782, 2676, 1211, 1706, 391, 437, 2306, 2980, 1310, 946, 1314, 861, 2249, 2312, 62, 352, 713, 784, 1625, 2563, 564, 2956, 565, 1162, 1322, 167]}}, "Interactions of rev with host cellular proteins": {"direction": "dw", "overlap": {"value": 18, "mean": 11.58495145631068, "std": 6.180148829983814, "bin": {}}, "setsize": {"value": 34, "mean": 33.50728155339806, "std": 1.1564279570110754, "bin": {}}, "score": {"value": -3.28297221938443, "mean": -0.3478389893094789, "std": 0.7452203314494521, "bin": {}}, "pval": {"value": 0.0010271878775109, "mean": 0.6970029102376685, "std": 0.2988264925058257, "bin": {}}, "signature_idxs": {"edge": [2688, 2528, 2527, 2781, 2782, 2969, 3176, 2915, 2639, 3009, 2805, 2702, 3189, 2676, 2779, 2771, 2773, 2755], "full": [1868, 2688, 3176, 2639, 1560, 2805, 669, 1810, 1109, 2755, 2702, 2527, 202, 2528, 983, 2136, 3189, 1058, 2969, 3009, 2771, 1759, 2231, 2437, 2073, 2773, 2915, 2079, 2779, 2781, 2782, 2676, 2306, 2312]}}, "Slc transporter disorders": {"direction": "dw", "overlap": {"value": 25, "mean": 10.072815533980584, "std": 5.627130779592072, "bin": {}}, "setsize": {"value": 32, "mean": 32.68689320388349, "std": 1.491569531804079, "bin": {}}, "score": {"value": -3.253525172557179, "mean": 0.1121793221691444, "std": 1.0244067182438623, "bin": {}}, "pval": {"value": 0.0011398262606814, "mean": 0.6146102245245559, "std": 0.3378443700099887, "bin": {}}, "signature_idxs": {"edge": [2528, 2527, 2231, 2805, 2413, 2688, 2969, 3009, 2702, 2779, 2771, 2773, 2781, 2782, 2915, 2676, 2437, 2755, 2430, 2306, 2312, 2639, 2267, 3189, 2136], "full": [2688, 1957, 2639, 2413, 1253, 2805, 669, 2755, 2702, 2527, 2267, 202, 2528, 2136, 3189, 2969, 2430, 3009, 2771, 1759, 2231, 2437, 2073, 2773, 2915, 2079, 2779, 2781, 2782, 2676, 2306, 2312]}}, "Transport of fatty acids": {"direction": "dw", "overlap": {"value": 1, "mean": 0.7087378640776699, "std": 0.4543440371571879, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -3.237374981812265, "mean": -0.7802911654939544, "std": 1.5584792786376886, "bin": {}}, "pval": {"value": 0.0012063478325581, "mean": 0.2863158124703265, "std": 0.273955430751647, "bin": {}}, "signature_idxs": {"edge": [2430], "full": [2430]}}, "Ptk6 expression": {"direction": "dw", "overlap": {"value": 1, "mean": 0.6966019417475728, "std": 0.5001825946166008, "bin": {}}, "setsize": {"value": 1, "mean": 1.174757281553398, "std": 0.3797593634098631, "bin": {}}, "score": {"value": -3.2302972934424923, "mean": -0.6428326828928079, "std": 1.9102667799251256, "bin": {}}, "pval": {"value": 0.0012366155870329, "mean": 0.2745964442724905, "std": 0.3102580330201498, "bin": {}}, "signature_idxs": {"edge": [2436], "full": [2436]}}, "Assembly of active lpl and lipc lipase complexes": {"direction": "up", "overlap": {"value": 0, "mean": 0.2733118971061093, "std": 0.4456596279744991, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 7, "bin_100": 7, "bin_250": 7, "bin_500": 7}}, "score": {"value": 3.2285542687692907, "mean": 1.00371785033471, "std": 1.903647207670957, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0012441764974173, "mean": 0.1775133460681621, "std": 0.233581779283167, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [856]}}, "Cd28 dependent pi3k akt signaling": {"direction": "dw", "overlap": {"value": 1, "mean": 0.8786407766990292, "std": 0.8124218242226036, "bin": {}}, "setsize": {"value": 1, "mean": 2.4271844660194173, "std": 0.8824276063991847, "bin": {}}, "score": {"value": -3.224985124020052, "mean": 0.6359011875985089, "std": 1.098963887517207, "bin": {}}, "pval": {"value": 0.0012597921469463, "mean": 0.4652144063244838, "std": 0.3226112748806718, "bin": {}}, "signature_idxs": {"edge": [2342], "full": [2342]}}, "B wich complex positively regulates rrna expression": {"direction": "dw", "overlap": {"value": 11, "mean": 9.730582524271844, "std": 3.736819769638691, "bin": {}}, "setsize": {"value": 17, "mean": 18.453883495145632, "std": 1.5611513880240862, "bin": {}}, "score": {"value": -3.2244387641260253, "mean": -1.1408645811192228, "std": 0.9816943120747184, "bin": {}}, "pval": {"value": 0.0012621984777718, "mean": 0.3454270386246533, "std": 0.3276222351285552, "bin": {}}, "signature_idxs": {"edge": [2991, 3056, 2568, 2641, 2923, 2745, 2850, 2839, 2840, 2904, 3198], "full": [2745, 3198, 1634, 2568, 2850, 2991, 2641, 1888, 1259, 1351, 2904, 3056, 2300, 2839, 2840, 2391, 2923]}}, "Choline catabolism": {"direction": "dw", "overlap": {"value": 1, "mean": 0.9101941747572816, "std": 0.4613119336850514, "bin": {}}, "setsize": {"value": 1, "mean": 1.296116504854369, "std": 0.516414511406939, "bin": {}}, "score": {"value": -3.219669604734147, "mean": -1.6165996630332595, "std": 1.7944375627524491, "bin": {}}, "pval": {"value": 0.0012833841749984, "mean": 0.146782453012119, "std": 0.2300685534210116, "bin": {}}, "signature_idxs": {"edge": [2344], "full": [2344]}}, "Notch4 activation and transmission of signal to the nucleus": {"direction": "dw", "overlap": {"value": 1, "mean": 0.6893203883495146, "std": 0.7244566254826263, "bin": {}}, "setsize": {"value": 1, "mean": 2.0485436893203883, "std": 0.2915855809258487, "bin": {}}, "score": {"value": -3.2143507317116, "mean": 0.3182846738998617, "std": 1.1377609786448692, "bin": {}}, "pval": {"value": 0.0013073987077545, "mean": 0.5141497653797525, "std": 0.3324019692791219, "bin": {}}, "signature_idxs": {"edge": [2348], "full": [2348]}}, "Rna polymerase ii transcription termination": {"direction": "dw", "overlap": {"value": 24, "mean": 17.20873786407767, "std": 7.0779379202652954, "bin": {}}, "setsize": {"value": 43, "mean": 44.70145631067961, "std": 3.184564992246008, "bin": {}}, "score": {"value": -3.2065086293245977, "mean": -0.86103981823213, "std": 1.0646102763598504, "bin": {}}, "pval": {"value": 0.0013435627518307, "mean": 0.4512938122200936, "std": 0.3419500531624954, "bin": {}}, "signature_idxs": {"edge": [2939, 2532, 3088, 2422, 2421, 2415, 3098, 3095, 3104, 2884, 2355, 3126, 2856, 2584, 2479, 2775, 2353, 2657, 2890, 2629, 2761, 2632, 2942, 2726], "full": [2629, 507, 2632, 2890, 290, 1565, 2856, 2415, 808, 1964, 1580, 2421, 2939, 2422, 606, 2584, 1584, 2057, 2353, 2355, 2657, 2059, 2479, 155, 2761, 3126, 2532, 3095, 2942, 3104, 1688, 1068, 1606, 3098, 1998, 2775, 1528, 1001, 2726, 2884, 1623, 3088, 1943]}}, "Phospholipid metabolism": {"direction": "dw", "overlap": {"value": 24, "mean": 12.859223300970871, "std": 6.241466981115118, "bin": {}}, "setsize": {"value": 44, "mean": 45.932038834951456, "std": 7.362344677079641, "bin": {}}, "score": {"value": -3.206487872067814, "mean": 1.017004520648936, "std": 1.3242274243570669, "bin": {}}, "pval": {"value": 0.0013436596871865, "mean": 0.3949296504793965, "std": 0.3709328103546776, "bin": {}}, "signature_idxs": {"edge": [3200, 2728, 3082, 2598, 2739, 2809, 2807, 2877, 2389, 2968, 2865, 2853, 2460, 2992, 2323, 2478, 3037, 2352, 2292, 3173, 2264, 3194, 2398, 3065], "full": [2398, 3194, 2323, 2460, 2853, 2992, 364, 1244, 1960, 1656, 2807, 2264, 3065, 1045, 2809, 1502, 1421, 2352, 2478, 1826, 117, 2968, 2143, 2598, 2865, 995, 3200, 3173, 3082, 1916, 1522, 1523, 2292, 2877, 1208, 1378, 1004, 3037, 2009, 2728, 2389, 1619, 2739, 865]}}, "Nuclear envelope breakdown": {"direction": "dw", "overlap": {"value": 28, "mean": 12.973300970873789, "std": 5.8489701837492225, "bin": {}}, "setsize": {"value": 42, "mean": 40.713592233009706, "std": 1.9284557202056891, "bin": {}}, "score": {"value": -3.1900019099867327, "mean": -0.1024410164721968, "std": 0.8745911279660593, "bin": {}}, "pval": {"value": 0.0014227185344939, "mean": 0.6694745338002839, "std": 0.3250750231346003, "bin": {}}, "signature_idxs": {"edge": [2528, 2527, 2409, 3213, 2805, 2688, 2958, 2960, 2969, 3009, 2702, 2779, 2771, 2773, 2781, 2782, 2915, 3157, 2676, 2437, 2755, 2316, 2306, 2312, 2639, 3189, 2526, 2402], "full": [2958, 2688, 2402, 2960, 2409, 511, 2639, 726, 3213, 2805, 669, 1734, 2046, 2755, 2702, 2526, 2527, 1818, 202, 2528, 2136, 3189, 2969, 3009, 2771, 3157, 1759, 2231, 2437, 427, 2073, 2773, 2915, 2079, 2779, 209, 2781, 2782, 2676, 2306, 2312, 2316]}}, "Sumoylation of sumoylation proteins": {"direction": "dw", "overlap": {"value": 17, "mean": 9.364077669902912, "std": 5.357461983681149, "bin": {}}, "setsize": {"value": 27, "mean": 26.98543689320388, "std": 1.422694542261493, "bin": {}}, "score": {"value": -3.161336398750006, "mean": -0.1342035149990308, "std": 0.8750751469170204, "bin": {}}, "pval": {"value": 0.0015704701149925, "mean": 0.667173865212816, "std": 0.3180062055057211, "bin": {}}, "signature_idxs": {"edge": [2688, 2528, 2527, 2781, 2782, 2969, 2639, 2915, 3009, 2805, 2702, 3189, 2676, 2779, 2771, 2773, 2755], "full": [2688, 2639, 2805, 669, 2755, 2702, 2527, 202, 2528, 2136, 3189, 2969, 3009, 2771, 1759, 2231, 2437, 2073, 2773, 2915, 2079, 2779, 2781, 2782, 2676, 2306, 2312]}}, "Regulation of glucokinase by glucokinase regulatory protein": {"direction": "dw", "overlap": {"value": 17, "mean": 9.191747572815531, "std": 5.165666138527258, "bin": {}}, "setsize": {"value": 27, "mean": 26.50728155339806, "std": 1.1564279570110754, "bin": {}}, "score": {"value": -3.161336398750006, "mean": -0.1342835103477938, "std": 0.9005781973200726, "bin": {}}, "pval": {"value": 0.0015704701149925, "mean": 0.6587239091779541, "std": 0.3228729436852376, "bin": {}}, "signature_idxs": {"edge": [2688, 2528, 2527, 2781, 2782, 2969, 2639, 2915, 3009, 2805, 2702, 3189, 2676, 2779, 2771, 2773, 2755], "full": [2688, 2639, 2805, 669, 2755, 2702, 2527, 202, 2528, 2136, 3189, 2969, 3009, 2771, 1759, 2231, 2437, 2073, 2773, 2915, 2079, 2779, 2781, 2782, 2676, 2306, 2312]}}, "Cellular response to chemical stress": {"direction": "up", "overlap": {"value": 38, "mean": 16.92233009708738, "std": 7.443234134196828, "bin": {"bin_50": 1, "bin_100": 4, "bin_250": 11, "bin_500": 22}}, "setsize": {"value": 78, "mean": 74.85436893203884, "std": 3.8890130701767585, "bin": {"bin_50": 133, "bin_100": 133, "bin_250": 133, "bin_500": 133}}, "score": {"value": 3.1403175767452223, "mean": 0.6393995551476427, "std": 0.935566980068825, "bin": {"bin_50": 1.5806502525252526, "bin_100": 3.2535291717666257, "bin_250": 3.738189112540638, "bin_500": 3.991861609508669}}, "pval": {"value": 0.0016876477729099, "mean": 0.564482392286313, "std": 0.3664371412566685, "bin": {"bin_50": 0.4752886178187883, "bin_100": 0.0403194900332572, "bin_250": 0.0003899955689035, "bin_500": 4.251031732343522e-07}}, "signature_idxs": {"edge": [592, 368, 370, 373, 738, 258, 713, 26, 151, 514, 515, 651, 181, 527, 526, 407, 409, 62, 855, 179, 297, 797, 298, 71, 79, 603, 814, 381, 458, 568, 716, 224, 225, 227, 916, 115, 364, 590], "full": [1088, 568, 26, 2927, 1024, 1629, 958, 1167, 1798, 651, 1555, 716, 1235, 3123, 2993, 2411, 2332, 2898, 2122, 797, 364, 1040, 1562, 590, 115, 407, 224, 514, 515, 458, 225, 592, 79, 1406, 1248, 2753, 368, 370, 409, 2525, 373, 1258, 227, 738, 526, 1739, 297, 527, 151, 814, 298, 179, 603, 181, 1421, 1974, 258, 907, 381, 1057, 1191, 2425, 2358, 912, 1679, 916, 1202, 3158, 1288, 71, 2080, 2670, 855, 1209, 2164, 62, 713, 3058]}}, "Organic anion transporters": {"direction": "dw", "overlap": {"value": 1, "mean": 0.4975728155339806, "std": 0.6479946152530336, "bin": {}}, "setsize": {"value": 1, "mean": 1.7766990291262137, "std": 0.4164584580490722, "bin": {}}, "score": {"value": -3.1359528321873937, "mean": 0.943754548157031, "std": 1.5400721032625413, "bin": {}}, "pval": {"value": 0.0017129675130953, "mean": 0.331266775835891, "std": 0.3230557458235638, "bin": {}}, "signature_idxs": {"edge": [2392], "full": [2392]}}, "Sulfide oxidation to sulfate": {"direction": "dw", "overlap": {"value": 1, "mean": 0.4271844660194174, "std": 0.6438950307561643, "bin": {}}, "setsize": {"value": 1, "mean": 1.6092233009708738, "std": 0.5995243896840202, "bin": {}}, "score": {"value": -3.1359528321873937, "mean": 1.0753216452919132, "std": 1.6878822142119727, "bin": {}}, "pval": {"value": 0.0017129675130953, "mean": 0.2683631361280069, "std": 0.3033865409383088, "bin": {}}, "signature_idxs": {"edge": [2392], "full": [2392]}}, "Signaling by egfr": {"direction": "up", "overlap": {"value": 7, "mean": 4.422330097087379, "std": 2.6660917193683447, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 4, "bin_500": 5}}, "setsize": {"value": 12, "mean": 11.62864077669903, "std": 2.2706346354395395, "bin": {"bin_50": 40, "bin_100": 40, "bin_250": 40, "bin_500": 40}}, "score": {"value": 3.133794839384912, "mean": -0.2535841102110117, "std": 0.8499472618691678, "bin": {"bin_50": 5.39957264957265, "bin_100": 2.631606488749346, "bin_250": 4.5136612021857925, "bin_500": 2.800057954216169}}, "pval": {"value": 0.0017256146035813, "mean": 0.5656759659278947, "std": 0.3034374152532696, "bin": {"bin_50": 0.1755724648168266, "bin_100": 0.3236452024265956, "bin_250": 0.0157211013123339, "bin_500": 0.0438404511308739}}, "signature_idxs": {"edge": [0, 116, 107, 201, 597, 417, 505], "full": [1726, 201, 1485, 587, 597, 0, 1661, 1266, 116, 417, 107, 505]}}, "Passive transport by aquaporins": {"direction": "dw", "overlap": {"value": 1, "mean": 0.2065491183879093, "std": 0.4048290751429382, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -3.119826829400872, "mean": 1.147839889154478, "std": 1.6711168772637148, "bin": {}}, "pval": {"value": 0.0018095738897283, "mean": 0.2042509716132917, "std": 0.2414556156488147, "bin": {}}, "signature_idxs": {"edge": [2378], "full": [2378]}}, "Copi mediated anterograde transport": {"direction": "up", "overlap": {"value": 17, "mean": 14.364077669902912, "std": 6.303679837135847, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 10, "bin_500": 18}}, "setsize": {"value": 55, "mean": 53.29368932038835, "std": 4.572358803691129, "bin": {"bin_50": 89, "bin_100": 89, "bin_250": 89, "bin_500": 89}}, "score": {"value": 3.09049051046426, "mean": 0.4832864212749729, "std": 1.0202251873333663, "bin": {"bin_50": 2.3813920454545454, "bin_100": 3.637718023255814, "bin_250": 5.248909690458462, "bin_500": 5.084683098591549}}, "pval": {"value": 0.0019982618992877, "mean": 0.5898511157237575, "std": 0.3614704266753352, "bin": {"bin_50": 0.3498897642406863, "bin_100": 0.0554265344441834, "bin_250": 5.690052743100154e-05, "bin_500": 2.212256050346297e-07}}, "signature_idxs": {"edge": [143, 385, 8, 302, 191, 401, 127, 217, 51, 236, 296, 284, 270, 234, 55, 169, 474], "full": [284, 1632, 217, 169, 1327, 127, 401, 3153, 585, 3199, 1178, 1811, 8, 465, 1044, 1112, 296, 896, 1740, 1187, 1121, 900, 819, 2135, 302, 474, 2269, 234, 1271, 822, 55, 2589, 608, 2531, 236, 1431, 1676, 1831, 1280, 1442, 385, 1289, 270, 191, 1929, 143, 1766, 51, 942, 1311, 2023, 2741, 1715, 1716, 1322]}}, "Type i hemidesmosome assembly": {"direction": "dw", "overlap": {"value": 1, "mean": 1.0533980582524272, "std": 0.7153403065471614, "bin": {}}, "setsize": {"value": 1, "mean": 1.9684466019417477, "std": 0.5586691142236899, "bin": {}}, "score": {"value": -3.078475661133096, "mean": -0.4227793589046735, "std": 1.2510560366299253, "bin": {}}, "pval": {"value": 0.0020806252456213, "mean": 0.4705305472874796, "std": 0.3340176219073861, "bin": {}}, "signature_idxs": {"edge": [2277], "full": [2277]}}, "Creb phosphorylation": {"direction": "dw", "overlap": {"value": 1, "mean": 1.354368932038835, "std": 0.7278478315080003, "bin": {}}, "setsize": {"value": 1, "mean": 2.128640776699029, "std": 0.4931128556774282, "bin": {}}, "score": {"value": -3.0766731920576262, "mean": -0.4842077312291235, "std": 1.543626946766034, "bin": {}}, "pval": {"value": 0.0020932466020155, "mean": 0.3449276266108409, "std": 0.309545585176919, "bin": {}}, "signature_idxs": {"edge": [2278], "full": [2278]}}, "Meiotic synapsis": {"direction": "dw", "overlap": {"value": 10, "mean": 6.155339805825243, "std": 2.925473263690994, "bin": {}}, "setsize": {"value": 16, "mean": 15.49757281553398, "std": 1.8308292810495423, "bin": {}}, "score": {"value": -3.0614227634953752, "mean": -0.5443126206257733, "std": 0.9431609251180718, "bin": {}}, "pval": {"value": 0.0022028781708955, "mean": 0.4889366647353366, "std": 0.3148843297999692, "bin": {}}, "signature_idxs": {"edge": [2960, 2562, 2912, 3012, 3213, 2707, 3190, 3131, 2674, 3063], "full": [1946, 2329, 2960, 3213, 3063, 979, 1351, 2707, 3190, 2912, 3131, 3012, 2674, 1467, 2100, 2562]}}, "Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1": {"direction": "up", "overlap": {"value": 25, "mean": 14.026699029126211, "std": 7.183906351200202, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 18}}, "setsize": {"value": 51, "mean": 48.65533980582524, "std": 2.917580729254371, "bin": {"bin_50": 68, "bin_100": 68, "bin_250": 68, "bin_500": 68}}, "score": {"value": 3.059585193677905, "mean": 0.5636343266746052, "std": 1.1799230201059223, "bin": {"bin_50": 3.1343283582089554, "bin_100": 4.823076923076923, "bin_250": 6.311680022693426, "bin_500": 7.236}}, "pval": {"value": 0.0022164373907676, "mean": 0.5641920682636952, "std": 0.3753446211108022, "bin": {"bin_50": 0.2801168002074996, "bin_100": 0.028249351231176, "bin_250": 3.631703063430464e-05, "bin_500": 2.418729520374481e-09}}, "signature_idxs": {"edge": [370, 373, 258, 713, 26, 151, 514, 515, 407, 526, 527, 62, 179, 297, 298, 71, 381, 458, 568, 224, 225, 227, 115, 269, 590], "full": [1088, 568, 26, 1024, 1629, 1165, 958, 651, 1955, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 2996, 370, 373, 1258, 227, 738, 526, 1818, 297, 527, 151, 814, 298, 179, 258, 2588, 907, 381, 2358, 912, 71, 269, 855, 1209, 2919, 2844, 2248, 1782, 3120, 3169, 62, 713]}}, "Export of viral ribonucleoproteins from nucleus": {"direction": "dw", "overlap": {"value": 17, "mean": 9.808252427184469, "std": 5.676953053805842, "bin": {}}, "setsize": {"value": 29, "mean": 28.50728155339806, "std": 1.1564279570110754, "bin": {}}, "score": {"value": -3.059548761502806, "mean": -0.1738412669472448, "std": 0.8082327013713511, "bin": {}}, "pval": {"value": 0.0022167069912577, "mean": 0.6926358413753296, "std": 0.3093153100062942, "bin": {}}, "signature_idxs": {"edge": [2688, 2528, 2527, 2781, 2782, 2969, 2639, 2915, 3009, 2805, 2702, 3189, 2676, 2779, 2771, 2773, 2755], "full": [1868, 2688, 2639, 2805, 669, 2755, 2702, 2527, 202, 2528, 983, 2136, 3189, 2969, 3009, 2771, 1759, 2231, 2437, 2073, 2773, 2915, 2079, 2779, 2781, 2782, 2676, 2306, 2312]}}, "Transcriptional activation of mitochondrial biogenesis": {"direction": "dw", "overlap": {"value": 5, "mean": 3.75, "std": 2.038018502731447, "bin": {}}, "setsize": {"value": 16, "mean": 12.432038834951456, "std": 1.8754268688059847, "bin": {}}, "score": {"value": -3.0296103992805614, "mean": -0.1281260555520316, "std": 1.067682850482272, "bin": {}}, "pval": {"value": 0.0024486939109364, "mean": 0.4644247929939951, "std": 0.2998511345858375, "bin": {}}, "signature_idxs": {"edge": [3123, 3061, 3146, 3045, 3025], "full": [1545, 1798, 2117, 3123, 3146, 3061, 1812, 1499, 3045, 3025, 380, 1679, 1202, 1919, 2006, 1539]}}, "Sodium calcium exchangers": {"direction": "up", "overlap": {"value": 0, "mean": 0.6286407766990292, "std": 0.4831682425100708, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 3, "bin_100": 3, "bin_250": 3, "bin_500": 3}}, "score": {"value": 3.024616590672419, "mean": -0.5011899121923299, "std": 1.7645396006214291, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.002489484982362, "mean": 0.2612889577560998, "std": 0.271510210139216, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [891]}}, "Activation of rac1 downstream of nmdars": {"direction": "up", "overlap": {"value": 0, "mean": 0.9035532994923858, "std": 0.7612690203015221, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 2.1472081218274113, "std": 0.782845792838863, "bin": {"bin_50": 6, "bin_100": 6, "bin_250": 6, "bin_500": 6}}, "score": {"value": 3.017371868014429, "mean": 0.0479962093040415, "std": 1.0170954679482525, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0025497680899935, "mean": 0.5611091206099722, "std": 0.317875858326098, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [904]}}, "Killing mechanisms": {"direction": "up", "overlap": {"value": 0, "mean": 0.7284263959390863, "std": 0.5517430257011441, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.3071065989847717, "std": 0.4932027865256404, "bin": {"bin_50": 9, "bin_100": 9, "bin_250": 9, "bin_500": 9}}, "score": {"value": 3.017371868014429, "mean": -0.3381049271791174, "std": 1.3248125101507615, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0025497680899935, "mean": 0.4383245844544942, "std": 0.3255786072604015, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [904]}}, "Ntrk2 activates rac1": {"direction": "up", "overlap": {"value": 0, "mean": 0.6692307692307692, "std": 0.4704901133345547, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.017948717948718, "std": 0.1327650611897396, "bin": {"bin_50": 3, "bin_100": 3, "bin_250": 3, "bin_500": 3}}, "score": {"value": 3.017371868014429, "mean": -0.3894074564532417, "std": 1.445876939044526, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0025497680899935, "mean": 0.3614500557456397, "std": 0.2938578480159364, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [904]}}, "Intraflagellar transport": {"direction": "up", "overlap": {"value": 6, "mean": 4.337378640776699, "std": 2.588297210303363, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 2, "bin_500": 7}}, "setsize": {"value": 11, "mean": 11.78640776699029, "std": 1.9366194419276843, "bin": {"bin_50": 48, "bin_100": 48, "bin_250": 48, "bin_500": 48}}, "score": {"value": 3.0173424730155647, "mean": 0.4184039855108218, "std": 0.985149141751126, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 1.7500883704489218, "bin_500": 3.357955392181213}}, "pval": {"value": 0.0025500153811299, "mean": 0.5246655449830855, "std": 0.3282353201076422, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.3264636262265684, "bin_500": 0.0082199413511063}}, "signature_idxs": {"edge": [143, 302, 434, 270, 236, 281], "full": [401, 2135, 302, 236, 1995, 1525, 270, 143, 434, 1320, 281]}}, "Ns1 mediated effects on host pathways": {"direction": "dw", "overlap": {"value": 18, "mean": 10.939320388349516, "std": 5.8925415688028675, "bin": {}}, "setsize": {"value": 34, "mean": 32.98300970873787, "std": 1.4917906975653903, "bin": {}}, "score": {"value": -2.9978293637997284, "mean": -0.1810967911548925, "std": 0.8146032678639678, "bin": {}}, "pval": {"value": 0.0027190986895797, "mean": 0.688491122847481, "std": 0.3113724872920873, "bin": {}}, "signature_idxs": {"edge": [2688, 2528, 2527, 2781, 3104, 2782, 2969, 2639, 2915, 3009, 2805, 2702, 3189, 2676, 2779, 2771, 2773, 2755], "full": [1473, 1391, 2688, 2639, 1336, 2805, 669, 2755, 2702, 1345, 102, 2527, 202, 2528, 2136, 3189, 1058, 2969, 3009, 3104, 2771, 1759, 2231, 2437, 2073, 2773, 2915, 2079, 2779, 2781, 2782, 2676, 2306, 2312]}}, "Negative epigenetic regulation of rrna expression": {"direction": "dw", "overlap": {"value": 11, "mean": 10.021844660194176, "std": 3.995386720185007, "bin": {}}, "setsize": {"value": 25, "mean": 23.725728155339805, "std": 2.969099468568849, "bin": {}}, "score": {"value": -2.9871288468391657, "mean": -1.089822822238336, "std": 0.9351033783141092, "bin": {}}, "pval": {"value": 0.0028161100737607, "mean": 0.3700014384633002, "std": 0.3241716408405726, "bin": {}}, "signature_idxs": {"edge": [2926, 2991, 2766, 2568, 3150, 2641, 2670, 2839, 2904, 3198, 3108], "full": [2926, 3198, 1634, 2324, 2568, 574, 2991, 2123, 1103, 2641, 1404, 1339, 1351, 2904, 909, 1750, 2766, 618, 1695, 1923, 2670, 2300, 2839, 3108, 3150]}}, "Activation of atr in response to replication stress": {"direction": "up", "overlap": {"value": 8, "mean": 5.179611650485437, "std": 3.862537503467055, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 5}}, "setsize": {"value": 18, "mean": 19.679611650485437, "std": 3.0152157572513594, "bin": {"bin_50": 38, "bin_100": 38, "bin_250": 38, "bin_500": 38}}, "score": {"value": 2.954608865442198, "mean": 0.1285647335300941, "std": 0.7447824953405174, "bin": {"bin_50": 5.692567567567568, "bin_100": 2.7744070601213457, "bin_250": 1.084473137104716, "bin_500": 2.970373102218944}}, "pval": {"value": 0.0031306567777558, "mean": 0.6575195684392049, "std": 0.2942694440452609, "bin": {"bin_50": 0.1675604235637086, "bin_100": 0.3102657432506607, "bin_250": 0.6083683872182535, "bin_500": 0.0361785711536894}}, "signature_idxs": {"edge": [357, 369, 570, 329, 21, 292, 591, 589], "full": [357, 1796, 570, 1242, 589, 1489, 591, 731, 1407, 1252, 21, 329, 369, 292, 1496, 1186, 1591, 1156]}}, "Transport of the slbp dependant mature mrna": {"direction": "dw", "overlap": {"value": 24, "mean": 10.322815533980584, "std": 5.796731907776354, "bin": {}}, "setsize": {"value": 31, "mean": 30.57281553398058, "std": 1.4217583926734303, "bin": {}}, "score": {"value": -2.9393980718627084, "mean": -0.2113838159701244, "std": 0.8670118169659932, "bin": {}}, "pval": {"value": 0.0032885041497889, "mean": 0.6750134343387901, "std": 0.3193959539823727, "bin": {}}, "signature_idxs": {"edge": [2528, 2527, 2231, 2805, 2621, 2688, 2969, 3009, 2702, 2355, 2779, 2771, 2773, 2781, 2782, 2915, 2676, 2437, 2755, 2306, 2312, 2639, 3189, 2136], "full": [2688, 359, 2639, 2805, 669, 2755, 2702, 1964, 2527, 202, 2528, 2136, 2355, 3189, 2969, 3009, 2771, 1759, 2231, 2437, 2073, 2773, 2915, 2079, 2779, 2781, 2782, 2676, 2306, 2621, 2312]}}, "Regulation of mrna stability by proteins that bind au rich elements": {"direction": "up", "overlap": {"value": 25, "mean": 17.303398058252426, "std": 8.19973289328142, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 9, "bin_500": 16}}, "setsize": {"value": 65, "mean": 62.189320388349515, "std": 2.9201480419101515, "bin": {"bin_50": 79, "bin_100": 79, "bin_250": 79, "bin_500": 79}}, "score": {"value": 2.9340358461451723, "mean": 0.3637537395774206, "std": 1.0954480785949263, "bin": {"bin_50": 2.689369658119658, "bin_100": 4.120476973684211, "bin_250": 5.313927077106993, "bin_500": 5.076730553908977}}, "pval": {"value": 0.0033458556468251, "mean": 0.6066390862029128, "std": 0.3602041660944462, "bin": {"bin_50": 0.3175327074700926, "bin_100": 0.0413282647695778, "bin_250": 0.0001202222452146, "bin_500": 1.023640450539033e-06}}, "signature_idxs": {"edge": [370, 373, 258, 713, 26, 151, 514, 515, 651, 407, 526, 527, 62, 179, 297, 298, 71, 458, 568, 224, 225, 227, 115, 545, 590], "full": [1088, 568, 26, 1024, 1629, 1868, 958, 651, 1950, 2118, 657, 1559, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 2700, 2805, 370, 2340, 373, 1258, 227, 738, 526, 297, 527, 151, 814, 298, 179, 2348, 1268, 1974, 2423, 258, 907, 1978, 1901, 2358, 912, 1507, 2537, 2488, 1986, 2866, 71, 545, 1525, 1922, 855, 1209, 2242, 2979, 2557, 62, 713, 1221, 2395]}}, "Glycerophospholipid catabolism": {"direction": "dw", "overlap": {"value": 2, "mean": 0.7599009900990099, "std": 0.6669540561157993, "bin": {}}, "setsize": {"value": 2, "mean": 1.7103960396039604, "std": 0.6769111862303069, "bin": {}}, "score": {"value": -2.9308251256098874, "mean": 0.0045978866199124, "std": 1.5361079594669371, "bin": {}}, "pval": {"value": 0.0033806302835364, "mean": 0.3663711899279772, "std": 0.314282651294633, "bin": {}}, "signature_idxs": {"edge": [3200, 3173], "full": [3200, 3173]}}, "Biosynthesis of specialized proresolving mediators spms": {"direction": "up", "overlap": {"value": 0, "mean": 0.9393203883495146, "std": 0.7966602157087129, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 2.5266990291262137, "std": 0.6659293649669392, "bin": {"bin_50": 6, "bin_100": 6, "bin_250": 6, "bin_500": 6}}, "score": {"value": 2.9262945194796157, "mean": 0.0633435563327127, "std": 1.4388897822683393, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.003430260250465, "mean": 0.3820783904611275, "std": 0.3174124716680312, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [966]}}, "Synthesis of leukotrienes lt and eoxins ex": {"direction": "up", "overlap": {"value": 0, "mean": 0.8252427184466019, "std": 0.6259312978526037, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 2.3810679611650487, "std": 0.5599330969421105, "bin": {"bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 2.9262945194796157, "mean": 0.138392279920101, "std": 1.3402955178470497, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.003430260250465, "mean": 0.4384029819702935, "std": 0.3206075565380266, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [966]}}, "Biosynthesis of epa derived spms": {"direction": "up", "overlap": {"value": 0, "mean": 0.3228155339805825, "std": 0.4675528472819023, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 3, "bin_100": 3, "bin_250": 3, "bin_500": 3}}, "score": {"value": 2.9262945194796157, "mean": 0.7066921230298423, "std": 1.831151181231286, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.003430260250465, "mean": 0.2366513075315446, "std": 0.280493854485681, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [966]}}, "Glycerophospholipid biosynthesis": {"direction": "dw", "overlap": {"value": 16, "mean": 9.439320388349516, "std": 4.809346434845489, "bin": {}}, "setsize": {"value": 25, "mean": 29.58009708737864, "std": 4.094857299253986, "bin": {}}, "score": {"value": -2.9131639410613666, "mean": 1.1800609247564997, "std": 1.3402414818469337, "bin": {}}, "pval": {"value": 0.0035778671024577, "mean": 0.3081196451067344, "std": 0.3224557628717913, "bin": {}}, "signature_idxs": {"edge": [2877, 2992, 3194, 2323, 2728, 2968, 2598, 3037, 2739, 2264, 2865, 2292, 2460, 2853, 2809, 3065], "full": [3194, 2323, 2460, 2853, 2992, 364, 1656, 2264, 3065, 1045, 2809, 1421, 2968, 2143, 2598, 2865, 995, 1916, 1523, 2292, 2877, 1004, 3037, 2728, 2739]}}, "Positive epigenetic regulation of rrna expression": {"direction": "dw", "overlap": {"value": 12, "mean": 14.16747572815534, "std": 5.601543687797506, "bin": {}}, "setsize": {"value": 27, "mean": 28.83495145631068, "std": 2.4449158159654645, "bin": {}}, "score": {"value": -2.907254087851672, "mean": -1.162471689203394, "std": 1.0574615836436132, "bin": {}}, "pval": {"value": 0.003646168999116, "mean": 0.3493309276909624, "std": 0.3383903298109247, "bin": {}}, "signature_idxs": {"edge": [2991, 3056, 2904, 2568, 2641, 2923, 2745, 2850, 2839, 2840, 2712, 3198], "full": [2745, 3198, 1634, 2568, 2850, 1723, 2991, 580, 2641, 1888, 1259, 1351, 2904, 821, 1353, 2273, 909, 2219, 2712, 2075, 1695, 3056, 2300, 2839, 2840, 2391, 2923]}}, "Protein folding": {"direction": "up", "overlap": {"value": 17, "mean": 10.774271844660197, "std": 6.173464842299678, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 5, "bin_500": 12}}, "setsize": {"value": 33, "mean": 35.78883495145631, "std": 2.9323392037362743, "bin": {"bin_50": 79, "bin_100": 79, "bin_250": 79, "bin_500": 79}}, "score": {"value": 2.903610168155915, "mean": 0.0501110689574452, "std": 0.7842910734427948, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 2.7455233010788564, "bin_500": 3.549290584116455}}, "pval": {"value": 0.0036888716098619, "mean": 0.6887797998333367, "std": 0.3079182125246192, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0430672573908121, "bin_500": 0.0004157189388758}}, "signature_idxs": {"edge": [143, 178, 777, 662, 775, 302, 208, 401, 364, 530, 409, 757, 376, 466, 294, 236, 245], "full": [2185, 1552, 2895, 401, 3022, 662, 364, 1254, 733, 409, 294, 466, 376, 895, 178, 1822, 1504, 1421, 302, 530, 236, 913, 757, 208, 1076, 775, 1531, 143, 777, 2505, 2014, 1017, 245]}}, "Cell cycle checkpoints": {"direction": "up", "overlap": {"value": 44, "mean": 35.737864077669904, "std": 14.89377348564558, "bin": {"bin_50": 4, "bin_100": 7, "bin_250": 16, "bin_500": 32}}, "setsize": {"value": 140, "mean": 139.23300970873785, "std": 13.286392691301824, "bin": {"bin_50": 257, "bin_100": 257, "bin_250": 257, "bin_500": 257}}, "score": {"value": 2.9003675221503067, "mean": 0.0395895335097635, "std": 0.9326100500655764, "bin": {"bin_50": 3.476152832674572, "bin_100": 2.9969130434782607, "bin_250": 2.77779367577622, "bin_500": 2.8911397234144016}}, "pval": {"value": 0.0037272535566774, "mean": 0.683101356311267, "std": 0.3317969957493373, "bin": {"bin_50": 0.034459684655003, "bin_100": 0.0124058411342335, "bin_250": 0.000536170702476, "bin_500": 9.526385085306732e-07}}, "signature_idxs": {"edge": [357, 369, 370, 9, 373, 21, 258, 538, 23, 713, 26, 306, 151, 511, 514, 515, 317, 527, 526, 407, 62, 179, 292, 169, 297, 298, 71, 329, 96, 323, 202, 458, 570, 103, 568, 224, 225, 227, 115, 269, 270, 591, 590, 589], "full": [870, 1088, 568, 26, 1024, 357, 1629, 1868, 169, 958, 1229, 2631, 323, 1796, 570, 1395, 2459, 1329, 651, 2402, 2116, 2637, 3022, 511, 726, 1242, 797, 1040, 589, 1489, 590, 115, 407, 224, 970, 591, 514, 515, 458, 225, 665, 1566, 2996, 2700, 731, 1407, 1252, 21, 329, 369, 370, 2045, 3063, 292, 1496, 802, 1342, 373, 1109, 1258, 227, 738, 1186, 2702, 2649, 1814, 526, 2527, 1818, 2581, 297, 202, 2528, 527, 103, 151, 1122, 814, 298, 1579, 179, 1351, 2348, 2135, 1269, 258, 3189, 2215, 2588, 907, 1130, 2589, 1748, 1676, 1591, 2906, 1592, 2358, 2062, 912, 538, 1062, 306, 2282, 1515, 1994, 1759, 2231, 2773, 2871, 71, 848, 2550, 2373, 269, 23, 2079, 270, 855, 1209, 2833, 933, 2377, 2676, 2919, 2881, 9, 96, 317, 1156, 2844, 2248, 1782, 3120, 3169, 62, 713, 1941, 1540, 1322]}}, "Cooperation of prefoldin and tric cct in actin and tubulin folding": {"direction": "up", "overlap": {"value": 14, "mean": 7.783980582524272, "std": 4.193665551388727, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 3, "bin_500": 8}}, "setsize": {"value": 16, "mean": 16.844660194174757, "std": 1.2695636552860448, "bin": {"bin_50": 28, "bin_100": 28, "bin_250": 28, "bin_500": 28}}, "score": {"value": 2.8950204237952093, "mean": 0.1576028180557599, "std": 1.1333901377691142, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 4.860244897959183, "bin_500": 7.900408163265306}}, "pval": {"value": 0.0037913386387418, "mean": 0.5228289011450986, "std": 0.3494472368572205, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.029757296929711, "bin_500": 3.998190987032918e-05}}, "signature_idxs": {"edge": [143, 178, 733, 775, 662, 302, 401, 530, 1017, 376, 466, 895, 294, 236], "full": [401, 662, 733, 294, 466, 376, 895, 178, 302, 530, 236, 1076, 775, 143, 2014, 1017]}}, "Separation of sister chromatids": {"direction": "up", "overlap": {"value": 32, "mean": 27.25728155339806, "std": 10.904342253831215, "bin": {"bin_50": 2, "bin_100": 4, "bin_250": 14, "bin_500": 28}}, "setsize": {"value": 106, "mean": 104.59466019417476, "std": 7.99139528936842, "bin": {"bin_50": 179, "bin_100": 179, "bin_250": 179, "bin_500": 179}}, "score": {"value": 2.892824947276667, "mean": 0.1913519656937572, "std": 0.9289444053822858, "bin": {"bin_50": 2.3969227070561367, "bin_100": 2.387248120300752, "bin_250": 3.5473193473193474, "bin_500": 3.7666056080033816}}, "pval": {"value": 0.0038179402095834, "mean": 0.6759734454858931, "std": 0.343574417926859, "bin": {"bin_50": 0.2124021777965604, "bin_100": 0.0962742426925034, "bin_250": 0.0001169534299547, "bin_500": 3.923139768359664e-08}}, "signature_idxs": {"edge": [143, 370, 373, 258, 538, 23, 26, 306, 151, 514, 515, 317, 302, 401, 527, 407, 62, 179, 169, 297, 298, 71, 323, 202, 236, 458, 224, 225, 227, 115, 269, 270], "full": [870, 1088, 568, 26, 1024, 1629, 1868, 169, 958, 1229, 2631, 323, 1946, 1395, 1329, 651, 401, 797, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 665, 1566, 2996, 370, 2045, 1342, 373, 1109, 1258, 227, 738, 2702, 1814, 526, 2527, 1818, 297, 202, 2528, 527, 151, 814, 298, 179, 2135, 302, 258, 3189, 2588, 907, 1130, 2589, 236, 1748, 1676, 1902, 2707, 1592, 2358, 2062, 912, 538, 1062, 1907, 306, 2282, 1515, 921, 2912, 1994, 1759, 2231, 2773, 2871, 71, 2550, 269, 23, 2079, 270, 855, 1209, 933, 143, 2676, 2919, 2881, 2734, 317, 2844, 2248, 1782, 3120, 3169, 62, 713, 2562, 1540, 1322]}}, "Vitamin b1 thiamin metabolism": {"direction": "dw", "overlap": {"value": 1, "mean": 0.3830409356725146, "std": 0.5320753734224442, "bin": {}}, "setsize": {"value": 1, "mean": 1.1169590643274854, "std": 0.321371500913078, "bin": {}}, "score": {"value": -2.881564550827464, "mean": 0.8276438058867299, "std": 1.856316597453883, "bin": {}}, "pval": {"value": 0.0039570617237578, "mean": 0.2237516804359743, "std": 0.2773217050898789, "bin": {}}, "signature_idxs": {"edge": [2240], "full": [2240]}}, "Interactions of vpr with host cellular proteins": {"direction": "dw", "overlap": {"value": 23, "mean": 10.941747572815531, "std": 5.4248175535845045, "bin": {}}, "setsize": {"value": 33, "mean": 33.44174757281554, "std": 1.1901720746801605, "bin": {}}, "score": {"value": -2.87905617634711, "mean": -0.2027749306543701, "std": 0.9115358979979576, "bin": {}}, "pval": {"value": 0.0039886727777658, "mean": 0.6500206570215948, "std": 0.3218663131177026, "bin": {}}, "signature_idxs": {"edge": [2528, 2527, 2408, 2805, 2688, 2958, 2969, 3009, 2702, 2779, 2771, 2334, 2773, 2781, 2782, 2915, 2676, 2437, 2755, 2306, 2312, 2639, 3189], "full": [1232, 2958, 2688, 2408, 1881, 2334, 2639, 2805, 669, 2755, 2702, 102, 2527, 202, 2528, 2136, 3189, 2969, 3009, 2771, 1759, 2231, 2437, 2073, 2773, 2915, 2079, 2779, 2781, 2782, 2676, 2306, 2312]}}, "Metabolism of steroids": {"direction": "dw", "overlap": {"value": 16, "mean": 11.16019417475728, "std": 4.702670999060317, "bin": {}}, "setsize": {"value": 39, "mean": 45.26699029126213, "std": 5.049423467032678, "bin": {}}, "score": {"value": -2.8748798871132992, "mean": 0.7621248609364072, "std": 1.2014135082145578, "bin": {}}, "pval": {"value": 0.0040418122386995, "mean": 0.3994790342082778, "std": 0.3371477938402821, "bin": {}}, "signature_idxs": {"edge": [3057, 2941, 2793, 2754, 2936, 2824, 3076, 2643, 2746, 2815, 2813, 2646, 2895, 2684, 2940, 2658], "full": [2746, 3076, 2684, 2793, 874, 963, 578, 2895, 404, 660, 1245, 2643, 1885, 2646, 2754, 2936, 1497, 2131, 1346, 983, 1267, 1505, 2658, 1588, 2940, 1058, 2813, 829, 2941, 1433, 1679, 2221, 2815, 2490, 1202, 2824, 1925, 491, 3057]}}, "Nucleotide biosynthesis": {"direction": "up", "overlap": {"value": 10, "mean": 7.033980582524272, "std": 3.266304981570562, "bin": {"bin_50": 0, "bin_100": 1, "bin_250": 2, "bin_500": 3}}, "setsize": {"value": 13, "mean": 12.769417475728156, "std": 0.7899469384204496, "bin": {"bin_50": 16, "bin_100": 16, "bin_250": 16, "bin_500": 16}}, "score": {"value": 2.8688195741999567, "mean": -0.6291215161387768, "std": 1.0604622489349396, "bin": {"bin_50": 0.0, "bin_100": 6.858503401360545, "bin_250": 5.768873403019745, "bin_500": 4.515151515151516}}, "pval": {"value": 0.0041200674960779, "mean": 0.435297047649795, "std": 0.333509206773144, "bin": {"bin_50": 1.0, "bin_100": 0.144637307685789, "bin_250": 0.0565188023636715, "bin_500": 0.0403506671570748}}, "signature_idxs": {"edge": [83, 667, 798, 253, 683, 586, 727, 228, 658, 593], "full": [1547, 83, 658, 253, 727, 586, 798, 1490, 593, 890, 667, 228, 683]}}, "Cytosolic trna aminoacylation": {"direction": "up", "overlap": {"value": 15, "mean": 14.300970873786408, "std": 4.932722030504012, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 2}}, "setsize": {"value": 23, "mean": 22.966019417475728, "std": 0.1811792000633157, "bin": {"bin_50": 24, "bin_100": 24, "bin_250": 24, "bin_500": 24}}, "score": {"value": 2.8663047543629183, "mean": -0.9200929801404824, "std": 1.2586096712426873, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 1.7470515754268614, "bin_500": 1.7734604105571847}}, "pval": {"value": 0.0041529424343313, "mean": 0.376538997117691, "std": 0.3534678527412684, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.4465871194719102, "bin_500": 0.3288847005661894}}, "signature_idxs": {"edge": [336, 969, 1111, 940, 1101, 866, 750, 196, 728, 897, 886, 524, 598, 1048, 1046], "full": [196, 1636, 1481, 1101, 886, 728, 969, 598, 1182, 1410, 1111, 1046, 524, 897, 1262, 1048, 1428, 750, 1594, 336, 940, 1468, 866]}}, "Cellular senescence": {"direction": "dw", "overlap": {"value": 11, "mean": 11.769417475728156, "std": 5.193604791339696, "bin": {}}, "setsize": {"value": 40, "mean": 40.18446601941748, "std": 5.935736060417647, "bin": {}}, "score": {"value": -2.856246098918984, "mean": -1.044134989742243, "std": 0.9968500929720716, "bin": {}}, "pval": {"value": 0.0042868271625047, "mean": 0.4026848380410546, "std": 0.3412217486607166, "bin": {}}, "signature_idxs": {"edge": [3169, 3116, 3120, 2996, 3213, 3214, 2919, 3190, 3004, 3022, 2932], "full": [2459, 3214, 2932, 3022, 1955, 719, 43, 1241, 1484, 1647, 3213, 589, 516, 2996, 409, 802, 2649, 1351, 1051, 821, 2588, 2359, 2278, 3190, 3004, 2488, 2434, 2373, 269, 2376, 2919, 3116, 1381, 1467, 2844, 2248, 1782, 3120, 3169, 639]}}, "Nectin necl trans heterodimerization": {"direction": "up", "overlap": {"value": 0, "mean": 0.5, "std": 0.5826069809991493, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.2642276422764227, "std": 0.4409210760821777, "bin": {"bin_50": 5, "bin_100": 5, "bin_250": 5, "bin_500": 5}}, "score": {"value": 2.8453450636748183, "mean": 0.3760315930650637, "std": 1.9368844499415276, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0044363335701542, "mean": 0.2774912495232864, "std": 0.3099952849665136, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1072]}}, "Cation coupled chloride cotransporters": {"direction": "dw", "overlap": {"value": 1, "mean": 0.4583333333333333, "std": 0.5286907308520633, "bin": {}}, "setsize": {"value": 1, "mean": 1.1666666666666667, "std": 0.3726779962499649, "bin": {}}, "score": {"value": -2.839036418015385, "mean": 0.4255621037314159, "std": 1.7047407116629996, "bin": {}}, "pval": {"value": 0.0045249992224341, "mean": 0.2956702977720128, "std": 0.2943850983896511, "bin": {}}, "signature_idxs": {"edge": [2133], "full": [2133]}}, "Postmitotic nuclear pore complex npc reformation": {"direction": "dw", "overlap": {"value": 13, "mean": 7.111650485436893, "std": 4.22856217319751, "bin": {}}, "setsize": {"value": 24, "mean": 22.59223300970874, "std": 1.1590663568117587, "bin": {}}, "score": {"value": -2.838281718970705, "mean": -0.1117781677326562, "std": 0.7215604680560269, "bin": {}}, "pval": {"value": 0.0045357130501253, "mean": 0.7061293342745426, "std": 0.2932294171855308, "bin": {}}, "signature_idxs": {"edge": [2688, 2528, 2527, 2871, 2781, 2782, 2969, 2915, 3009, 3189, 2676, 2771, 2773], "full": [2688, 1560, 669, 1109, 2527, 202, 2528, 983, 3189, 1058, 2969, 3009, 2771, 1759, 2231, 2437, 2773, 2871, 2915, 1525, 2079, 2781, 2782, 2676]}}, "Formation of tubulin folding intermediates by cct tric": {"direction": "up", "overlap": {"value": 10, "mean": 7.048543689320389, "std": 3.5400034029293583, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 2, "bin_500": 7}}, "setsize": {"value": 12, "mean": 12.572815533980584, "std": 1.010641839197911, "bin": {"bin_50": 21, "bin_100": 21, "bin_250": 21, "bin_500": 21}}, "score": {"value": 2.8372510149950543, "mean": -0.0299622497364015, "std": 1.1515695451851629, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 4.248609328198545, "bin_500": 9.861507128309572}}, "pval": {"value": 0.0045503822097032, "mean": 0.5033513771330486, "std": 0.3427470685828869, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0914454637274335, "bin_500": 4.0623087816283454e-05}}, "signature_idxs": {"edge": [143, 662, 775, 302, 401, 530, 376, 466, 294, 236], "full": [401, 662, 733, 294, 466, 376, 895, 302, 530, 236, 775, 143]}}, "A tetrasaccharide linker sequence is required for gag synthesis": {"direction": "up", "overlap": {"value": 0, "mean": 0.3973063973063973, "std": 0.5095645632967707, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.1313131313131313, "std": 0.3377424948949593, "bin": {"bin_50": 16, "bin_100": 16, "bin_250": 16, "bin_500": 16}}, "score": {"value": 2.836098375090617, "mean": 0.45713081522496, "std": 2.020892606866953, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0045668376729499, "mean": 0.2157135109124441, "std": 0.2748256479080779, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1075]}}, "Myd88 independent tlr4 cascade": {"direction": "up", "overlap": {"value": 8, "mean": 6.41747572815534, "std": 3.983641968951216, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 4, "bin_500": 7}}, "setsize": {"value": 19, "mean": 20.936893203883496, "std": 3.8334118821876553, "bin": {"bin_50": 78, "bin_100": 78, "bin_250": 78, "bin_500": 78}}, "score": {"value": 2.830820634211898, "mean": -0.3726029532975656, "std": 0.934011354832054, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 2.187416925121843, "bin_500": 1.933077077536502}}, "pval": {"value": 0.0046428749603499, "mean": 0.5410969666537427, "std": 0.3105743856640078, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1217442040930612, "bin_500": 0.085830205841584}}, "signature_idxs": {"edge": [136, 181, 103, 251, 256, 116, 304, 535], "full": [1225, 251, 516, 665, 1566, 256, 103, 181, 304, 116, 1131, 535, 1057, 1592, 2278, 1196, 2488, 136, 1314]}}, "Biological oxidations": {"direction": "up", "overlap": {"value": 25, "mean": 9.58980582524272, "std": 4.863095917627343, "bin": {"bin_50": 2, "bin_100": 3, "bin_250": 9, "bin_500": 12}}, "setsize": {"value": 49, "mean": 42.907766990291265, "std": 3.5143586004975274, "bin": {"bin_50": 94, "bin_100": 94, "bin_250": 94, "bin_500": 94}}, "score": {"value": 2.829548769079381, "mean": 0.5797258374932459, "std": 1.0031637620757048, "bin": {"bin_50": 4.650786308973173, "bin_100": 3.4361263736263736, "bin_250": 4.369529904011814, "bin_500": 2.8955133995784403}}, "pval": {"value": 0.0046613695105981, "mean": 0.4965502516733612, "std": 0.3373734498260092, "bin": {"bin_50": 0.0748187401998431, "bin_100": 0.0632302441478985, "bin_250": 0.000452953691518, "bin_500": 0.0019984236571286}}, "signature_idxs": {"edge": [277, 128, 249, 696, 710, 30, 446, 41, 650, 649, 187, 523, 170, 830, 171, 174, 804, 74, 666, 796, 771, 223, 774, 723, 588], "full": [1544, 2322, 2566, 249, 30, 170, 649, 650, 128, 171, 2331, 1954, 2750, 878, 794, 723, 796, 2192, 223, 2039, 1885, 588, 174, 3024, 666, 975, 804, 523, 41, 830, 2815, 1751, 2283, 2605, 187, 2719, 696, 74, 771, 1297, 774, 2302, 2013, 1537, 2096, 710, 277, 2105, 446]}}, "Mitochondrial translation": {"direction": "dw", "overlap": {"value": 32, "mean": 18.78640776699029, "std": 9.671196837047138, "bin": {}}, "setsize": {"value": 60, "mean": 54.44417475728155, "std": 5.612424674482629, "bin": {}}, "score": {"value": -2.8284302385409745, "mean": -0.5144488569198282, "std": 1.1580697551554602, "bin": {}}, "pval": {"value": 0.0046776894769808, "mean": 0.5469432198403718, "std": 0.3552289835032928, "bin": {}}, "signature_idxs": {"edge": [2266, 2087, 2721, 2106, 2129, 3207, 2742, 2938, 2092, 2371, 2619, 2502, 3011, 2188, 2381, 2053, 2864, 2210, 2155, 2666, 2166, 2473, 2167, 2541, 2174, 2289, 3020, 2655, 2115, 2648, 2952, 3066], "full": [3020, 2188, 2115, 1803, 2473, 1110, 2648, 2129, 2266, 3207, 2938, 1423, 2053, 1664, 2210, 2655, 3066, 1581, 1582, 1587, 988, 1360, 2541, 2289, 2864, 2666, 1443, 3011, 2371, 2155, 695, 1074, 2721, 2001, 1373, 2502, 1301, 2166, 2381, 2087, 29, 1705, 2167, 2092, 1932, 1708, 1463, 2016, 2174, 2952, 2619, 1779, 1384, 1714, 2106, 2742, 1786, 1942, 1542, 1543]}}, "Hdl clearance": {"direction": "dw", "overlap": {"value": 1, "mean": 0.1771844660194174, "std": 0.4239937659271693, "bin": {}}, "setsize": {"value": 2, "mean": 1.983009708737864, "std": 0.1292347525434382, "bin": {}}, "score": {"value": -2.816598982639128, "mean": 1.042770631722054, "std": 1.2384177151091718, "bin": {}}, "pval": {"value": 0.0048535084721408, "mean": 0.3170315338825873, "std": 0.276563564365398, "bin": {}}, "signature_idxs": {"edge": [3106], "full": [1583, 3106]}}, "Diseases of programmed cell death": {"direction": "dw", "overlap": {"value": 8, "mean": 8.101941747572816, "std": 3.596694290852278, "bin": {}}, "setsize": {"value": 28, "mean": 24.87621359223301, "std": 3.0706435290560345, "bin": {}}, "score": {"value": -2.800606419117588, "mean": -0.8084545584439394, "std": 0.8786913827745173, "bin": {}}, "pval": {"value": 0.0051006686449146, "mean": 0.4577746245997103, "std": 0.3202893327029611, "bin": {}}, "signature_idxs": {"edge": [3123, 2960, 3213, 3214, 3026, 3004, 3022, 3108], "full": [1634, 3214, 2960, 3123, 2406, 3022, 1956, 1482, 406, 3213, 2697, 1339, 368, 802, 737, 131, 1579, 1351, 531, 3026, 234, 821, 1747, 535, 260, 2359, 3004, 3108]}}, "Transport to the golgi and subsequent modification": {"direction": "up", "overlap": {"value": 22, "mean": 20.604368932038835, "std": 8.044251420264837, "bin": {"bin_50": 1, "bin_100": 4, "bin_250": 12, "bin_500": 20}}, "setsize": {"value": 77, "mean": 77.1626213592233, "std": 7.0373663516482345, "bin": {"bin_50": 148, "bin_100": 148, "bin_250": 148, "bin_500": 148}}, "score": {"value": 2.793232538751667, "mean": 0.4958457957496105, "std": 0.9638132242129624, "bin": {"bin_50": 1.417233560090703, "bin_100": 2.910233918128655, "bin_250": 3.668494516450648, "bin_500": 3.128268828451883}}, "pval": {"value": 0.0052184163418644, "mean": 0.6299790557050085, "std": 0.3700222187340509, "bin": {"bin_50": 0.5123592328378659, "bin_100": 0.0557509171156544, "bin_250": 0.0002568042655887, "bin_500": 3.260046772646197e-05}}, "signature_idxs": {"edge": [143, 8, 127, 191, 302, 401, 51, 284, 296, 55, 169, 608, 202, 234, 236, 85, 474, 578, 385, 217, 465, 270], "full": [955, 284, 789, 1632, 217, 169, 1327, 1872, 127, 874, 1639, 963, 578, 401, 3153, 585, 3199, 85, 1178, 1811, 8, 465, 1044, 1413, 1112, 296, 896, 1740, 1574, 1346, 1187, 202, 1121, 900, 819, 2135, 302, 474, 2269, 234, 1271, 1668, 822, 55, 2589, 608, 2531, 236, 1431, 1676, 1831, 1280, 1433, 993, 1985, 3191, 840, 1442, 385, 1996, 1289, 270, 191, 1929, 143, 1766, 51, 1859, 2387, 942, 1311, 2023, 2741, 1715, 1716, 1322, 1390]}}, "Lagging strand synthesis": {"direction": "up", "overlap": {"value": 11, "mean": 6.747572815533981, "std": 3.864120358841132, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 3, "bin_500": 8}}, "setsize": {"value": 19, "mean": 18.26941747572815, "std": 1.9315310719801264, "bin": {"bin_50": 23, "bin_100": 23, "bin_250": 23, "bin_500": 23}}, "score": {"value": 2.7833542832577924, "mean": -0.3375114835647878, "std": 0.9753035628226046, "bin": {"bin_50": 9.588068181818182, "bin_100": 4.6730055658627085, "bin_250": 6.078367346938776, "bin_500": 10.539319727891156}}, "pval": {"value": 0.0053800023120458, "mean": 0.5165119199723712, "std": 0.3252888828987217, "bin": {"bin_50": 0.1049896535105009, "bin_100": 0.2012104780589677, "bin_250": 0.0175758241055335, "bin_500": 7.832237274035295e-06}}, "signature_idxs": {"edge": [369, 737, 252, 130, 131, 329, 21, 729, 260, 292, 591], "full": [1482, 252, 1242, 1104, 591, 729, 21, 329, 369, 2043, 130, 292, 1496, 805, 737, 131, 260, 990, 2790]}}, "Collagen degradation": {"direction": "dw", "overlap": {"value": 1, "mean": 0.4153846153846154, "std": 0.5789196222223624, "bin": {}}, "setsize": {"value": 1, "mean": 1.2153846153846153, "std": 0.5498430832279061, "bin": {}}, "score": {"value": -2.779514702106378, "mean": 0.8505958227969029, "std": 2.1355588602584445, "bin": {}}, "pval": {"value": 0.0054440189124611, "mean": 0.1570025369283389, "std": 0.2547803024332081, "bin": {}}, "signature_idxs": {"edge": [2119], "full": [2119]}}, "Synthesis of substrates in n glycan biosythesis": {"direction": "up", "overlap": {"value": 8, "mean": 4.101941747572815, "std": 2.554131645515961, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 3}}, "setsize": {"value": 17, "mean": 15.29126213592233, "std": 2.6342813465607953, "bin": {"bin_50": 44, "bin_100": 44, "bin_250": 44, "bin_500": 44}}, "score": {"value": 2.7794301439498468, "mean": -0.0934295860101241, "std": 0.9880430361156176, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.9325863854627624, "bin_500": 1.4274944567627494}}, "pval": {"value": 0.0054454364407521, "mean": 0.4651486832142111, "std": 0.2693319722460128, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.6623596340642164, "bin_500": 0.3646272656082709}}, "signature_idxs": {"edge": [610, 622, 285, 199, 594, 631, 325, 768], "full": [285, 325, 1719, 199, 1879, 1646, 594, 747, 610, 1992, 1520, 768, 622, 631, 1621, 1160, 1790]}}, "Sphingolipid metabolism": {"direction": "dw", "overlap": {"value": 14, "mean": 11.00242718446602, "std": 4.192861933829232, "bin": {}}, "setsize": {"value": 24, "mean": 26.135922330097088, "std": 2.1968580551223003, "bin": {}}, "score": {"value": -2.7611114062116373, "mean": 1.1708540815039898, "std": 2.1941615995620167, "bin": {}}, "pval": {"value": 0.0057605022764266, "mean": 0.1757583754913391, "std": 0.2567064655985949, "bin": {}}, "signature_idxs": {"edge": [2957, 2763, 3060, 2895, 3203, 2308, 2466, 2673, 2650, 3015, 2397, 3092, 2191, 2253], "full": [2397, 2253, 2957, 2111, 1799, 3060, 2895, 2191, 1401, 1557, 2466, 1879, 3092, 1646, 3203, 1245, 2650, 2763, 2071, 312, 2673, 3015, 2308, 1937]}}, "Signaling by met": {"direction": "up", "overlap": {"value": 6, "mean": 5.317961165048544, "std": 2.716967133820142, "bin": {"bin_50": 1, "bin_100": 2, "bin_250": 5, "bin_500": 7}}, "setsize": {"value": 20, "mean": 18.281553398058257, "std": 2.703530506320385, "bin": {"bin_50": 64, "bin_100": 64, "bin_250": 64, "bin_500": 64}}, "score": {"value": 2.759643431392168, "mean": -0.4703384123541668, "std": 0.8034068590391176, "bin": {"bin_50": 3.3346560846560847, "bin_100": 3.3372131692716995, "bin_250": 3.448768919578713, "bin_500": 2.411369564440633}}, "pval": {"value": 0.0057864479935012, "mean": 0.552784959510498, "std": 0.3092945349320341, "bin": {"bin_50": 0.2660187864050092, "bin_100": 0.1279708837725801, "bin_250": 0.019457743384681, "bin_500": 0.0357291772744991}}, "signature_idxs": {"edge": [0, 107, 65, 409, 201, 116], "full": [1726, 2576, 201, 2260, 1244, 587, 409, 1655, 0, 65, 415, 1266, 904, 1896, 116, 1529, 1144, 1145, 107, 2980]}}, "Erythrocytes take up carbon dioxide and release oxygen": {"direction": "dw", "overlap": {"value": 1, "mean": 0.562015503875969, "std": 0.4961391712806092, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -2.743978574598154, "mean": -0.3120372013286817, "std": 1.8841401004840383, "bin": {}}, "pval": {"value": 0.0060699499456728, "mean": 0.2785498739329328, "std": 0.2937418053497576, "bin": {}}, "signature_idxs": {"edge": [2179], "full": [2179]}}, "Apoptosis induced dna fragmentation": {"direction": "up", "overlap": {"value": 7, "mean": 4.461165048543689, "std": 1.815774087232708, "bin": {"bin_50": 1, "bin_100": 2, "bin_250": 3, "bin_500": 5}}, "setsize": {"value": 11, "mean": 9.480582524271844, "std": 0.7956871918457745, "bin": {"bin_50": 11, "bin_100": 11, "bin_250": 11, "bin_500": 11}}, "score": {"value": 2.7438051883699743, "mean": -1.2396777487494677, "std": 1.1955398659006715, "bin": {"bin_50": 21.11875, "bin_100": 23.11111111111111, "bin_250": 15.214285714285714, "bin_500": 16.382691007437458}}, "pval": {"value": 0.006073156698888, "mean": 0.2413940671270342, "std": 0.28131040332984, "bin": {"bin_50": 0.0516364610584135, "bin_100": 0.0048484802924912, "bin_250": 0.0020298329670106, "bin_500": 9.8492817269125e-05}}, "signature_idxs": {"edge": [83, 663, 102, 43, 251, 356, 672], "full": [356, 83, 719, 251, 43, 1484, 1647, 663, 672, 102, 1058]}}, "Netrin mediated repulsion signals": {"direction": "up", "overlap": {"value": 1, "mean": 0.7253886010362695, "std": 0.5778537915681172, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 2, "bin_500": 2}}, "setsize": {"value": 2, "mean": 1.16580310880829, "std": 0.3719038019673857, "bin": {"bin_50": 5, "bin_100": 5, "bin_250": 5, "bin_500": 5}}, "score": {"value": 2.7152660740308185, "mean": -0.5932902009523442, "std": 1.7615398909628912, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 26.951219512195124, "bin_500": 13.030913978494624}}, "pval": {"value": 0.0066222541924343, "mean": 0.302641604270374, "std": 0.3133627859466923, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0056136137273067, "bin_500": 0.0215767580713982}}, "signature_idxs": {"edge": [116], "full": [201, 116]}}, "Fatty acyl coa biosynthesis": {"direction": "dw", "overlap": {"value": 8, "mean": 3.8640776699029127, "std": 2.5949859931504444, "bin": {}}, "setsize": {"value": 16, "mean": 15.514563106796116, "std": 1.4820222190196806, "bin": {}}, "score": {"value": -2.70532324110387, "mean": -0.1829808486879168, "std": 1.0812172032678584, "bin": {}}, "pval": {"value": 0.0068237953229819, "mean": 0.4222853765507983, "std": 0.2668945966653873, "bin": {}}, "signature_idxs": {"edge": [2857, 3138, 2571, 3183, 3076, 2490, 2843, 2658], "full": [3076, 2113, 2571, 1652, 1497, 2857, 2132, 1117, 2658, 1752, 2490, 3138, 1694, 3183, 2843, 1472]}}, "Gene silencing by rna": {"direction": "dw", "overlap": {"value": 20, "mean": 12.29611650485437, "std": 6.459333915134231, "bin": {}}, "setsize": {"value": 45, "mean": 45.92718446601942, "std": 2.8970253969267006, "bin": {}}, "score": {"value": -2.6996153603201725, "mean": -0.2332815004983215, "std": 0.5773915169279245, "bin": {}}, "pval": {"value": 0.0069419683801195, "mean": 0.7546919563629539, "std": 0.2741122000409035, "bin": {}}, "signature_idxs": {"edge": [2528, 2527, 2805, 2688, 2969, 2698, 3009, 2702, 2779, 2771, 2773, 2781, 2782, 2915, 2676, 2904, 2755, 2639, 2641, 3189], "full": [1869, 1474, 2688, 1237, 2639, 2038, 2641, 2698, 2338, 2805, 669, 2755, 2702, 2527, 202, 2528, 1663, 1351, 983, 2904, 2136, 3189, 914, 237, 2969, 3009, 2771, 1759, 2231, 2437, 2073, 2773, 2915, 2079, 2779, 2008, 1299, 2781, 2782, 2676, 780, 2306, 2312, 1159, 1222]}}, "Translesion synthesis by polh": {"direction": "up", "overlap": {"value": 6, "mean": 4.825242718446602, "std": 3.2558451826997414, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 5}}, "setsize": {"value": 12, "mean": 12.28883495145631, "std": 0.862695933530379, "bin": {"bin_50": 20, "bin_100": 20, "bin_250": 20, "bin_500": 20}}, "score": {"value": 2.6791893161145968, "mean": -0.2513791687876471, "std": 0.8859670011372885, "bin": {"bin_50": 11.105263157894736, "bin_100": 5.412459720730397, "bin_250": 2.11570424035798, "bin_500": 6.546991210277215}}, "pval": {"value": 0.0073800654781641, "mean": 0.5310257300609939, "std": 0.2967113716359582, "bin": {"bin_50": 0.0919337377678228, "bin_100": 0.1774332758731671, "bin_250": 0.3891747515056749, "bin_500": 0.0022923961599421}}, "signature_idxs": {"edge": [369, 252, 329, 21, 292, 591], "full": [252, 1242, 591, 21, 329, 369, 2043, 292, 1496, 676, 1367, 1761]}}, "Activation of gene expression by srebf srebp": {"direction": "dw", "overlap": {"value": 8, "mean": 4.5, "std": 1.9933140672944107, "bin": {}}, "setsize": {"value": 16, "mean": 17.614077669902912, "std": 2.3210927861941943, "bin": {}}, "score": {"value": -2.678697465751348, "mean": -0.4104789735438113, "std": 1.1966557776449334, "bin": {}}, "pval": {"value": 0.0073909138433465, "mean": 0.3678488977621815, "std": 0.274390460759911, "bin": {}}, "signature_idxs": {"edge": [3057, 2793, 2936, 3076, 2746, 2815, 2754, 2658], "full": [2746, 3076, 2793, 404, 2754, 2936, 1497, 1267, 1505, 2658, 1588, 829, 1679, 2815, 1202, 3057]}}, "Nr1h2 nr1h3 regulate gene expression linked to lipogenesis": {"direction": "dw", "overlap": {"value": 1, "mean": 0.8009708737864077, "std": 0.7167882987124449, "bin": {}}, "setsize": {"value": 2, "mean": 2.0024271844660193, "std": 0.3784151057644417, "bin": {}}, "score": {"value": -2.676112597635159, "mean": 0.2826761163451425, "std": 1.14092145231576, "bin": {}}, "pval": {"value": 0.0074481617616086, "mean": 0.5399083455965387, "std": 0.3216625820548595, "bin": {}}, "signature_idxs": {"edge": [3076], "full": [3076, 1497]}}, "Signaling by pdgf": {"direction": "up", "overlap": {"value": 5, "mean": 2.9101941747572817, "std": 1.6748258744923243, "bin": {"bin_50": 1, "bin_100": 2, "bin_250": 4, "bin_500": 5}}, "setsize": {"value": 9, "mean": 7.143203883495145, "std": 1.3693515676089445, "bin": {"bin_50": 35, "bin_100": 35, "bin_250": 35, "bin_500": 35}}, "score": {"value": 2.674907484069605, "mean": -0.3386949984053652, "std": 0.9460471493059344, "bin": {"bin_50": 6.196691176470588, "bin_100": 6.288034989065917, "bin_250": 5.244315177154944, "bin_500": 3.2684246112238}}, "pval": {"value": 0.0074749874813035, "mean": 0.4848571763301018, "std": 0.3004197647866201, "bin": {"bin_50": 0.1553991536419083, "bin_100": 0.045127039841821, "bin_250": 0.0098961463934591, "bin_500": 0.0263404288632578}}, "signature_idxs": {"edge": [34, 65, 409, 201, 116], "full": [1726, 201, 34, 1485, 409, 521, 65, 1266, 116]}}, "Downstream signal transduction": {"direction": "up", "overlap": {"value": 5, "mean": 2.9101941747572817, "std": 1.6748258744923243, "bin": {"bin_50": 1, "bin_100": 2, "bin_250": 4, "bin_500": 5}}, "setsize": {"value": 9, "mean": 7.143203883495145, "std": 1.3693515676089445, "bin": {"bin_50": 23, "bin_100": 23, "bin_250": 23, "bin_500": 23}}, "score": {"value": 2.674907484069605, "mean": -0.3386949984053652, "std": 0.9460471493059344, "bin": {"bin_50": 9.588068181818182, "bin_100": 9.892979872361316, "bin_250": 8.566867989646246, "bin_500": 5.454135677259409}}, "pval": {"value": 0.0074749874813035, "mean": 0.4848571763301018, "std": 0.3004197647866201, "bin": {"bin_50": 0.1049896535105009, "bin_100": 0.0206800818926893, "bin_250": 0.0021013452038761, "bin_500": 0.0044081397545113}}, "signature_idxs": {"edge": [34, 65, 409, 201, 116], "full": [1726, 201, 34, 1485, 409, 521, 65, 1266, 116]}}, "Golgi to er retrograde transport": {"direction": "up", "overlap": {"value": 17, "mean": 16.92233009708738, "std": 7.275693434924061, "bin": {"bin_50": 2, "bin_100": 3, "bin_250": 7, "bin_500": 18}}, "setsize": {"value": 68, "mean": 70.53883495145631, "std": 5.280109829133333, "bin": {"bin_50": 115, "bin_100": 115, "bin_250": 115, "bin_500": 115}}, "score": {"value": 2.666851788779587, "mean": 0.4559805501598206, "std": 0.9044409230983104, "bin": {"bin_50": 3.778572773488985, "bin_100": 2.7859933035714284, "bin_250": 2.6463808206546795, "bin_500": 3.7117268041237113}}, "pval": {"value": 0.0076565428784562, "mean": 0.6345143601474961, "std": 0.3556018909943214, "bin": {"bin_50": 0.1054077938723316, "bin_100": 0.1010318943027543, "bin_250": 0.0220112051509324, "bin_500": 1.063231760116795e-05}}, "signature_idxs": {"edge": [475, 143, 385, 6, 8, 302, 401, 127, 51, 473, 390, 236, 284, 270, 296, 169, 474], "full": [870, 284, 2887, 169, 1229, 1872, 127, 2990, 1641, 401, 585, 3199, 1251, 1178, 1342, 1811, 8, 465, 1044, 1112, 1817, 296, 896, 1740, 1187, 1121, 900, 819, 2135, 302, 473, 474, 3155, 475, 1975, 1746, 2759, 2589, 608, 236, 1431, 1676, 1903, 1593, 756, 1280, 1442, 385, 1289, 270, 933, 1929, 143, 1766, 390, 2090, 51, 1860, 1535, 6, 942, 1863, 1311, 2023, 1715, 1320, 1716, 1322]}}, "Glutathione conjugation": {"direction": "up", "overlap": {"value": 11, "mean": 4.902912621359223, "std": 2.89631356958045, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 5, "bin_500": 5}}, "setsize": {"value": 15, "mean": 13.932038834951456, "std": 1.468187813190985, "bin": {"bin_50": 21, "bin_100": 21, "bin_250": 21, "bin_500": 21}}, "score": {"value": 2.661497942502391, "mean": -0.4087279314114328, "std": 0.9463599771739029, "bin": {"bin_50": 10.548958333333331, "bin_100": 5.141326530612245, "bin_250": 12.772633744855968, "bin_500": 6.137170385395538}}, "pval": {"value": 0.0077793816364346, "mean": 0.4907677597801696, "std": 0.309389844445752, "bin": {"bin_50": 0.0963063052639835, "bin_100": 0.1854358412925483, "bin_250": 0.000120929284521, "bin_500": 0.0028896459807526}}, "signature_idxs": {"edge": [804, 771, 796, 223, 774, 41, 650, 187, 523, 170, 174], "full": [2322, 170, 650, 794, 796, 223, 174, 975, 804, 523, 41, 187, 771, 774, 2105]}}, "Digestion and absorption": {"direction": "up", "overlap": {"value": 0, "mean": 0.3442211055276382, "std": 0.475113603296063, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "score": {"value": 2.647199609300847, "mean": 0.6962697927632293, "std": 1.93348504508116, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0081161430415983, "mean": 0.2228430358983308, "std": 0.2739052325555903, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1091]}}, "Digestion": {"direction": "up", "overlap": {"value": 0, "mean": 0.3442211055276382, "std": 0.475113603296063, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "score": {"value": 2.647199609300847, "mean": 0.6962697927632293, "std": 1.93348504508116, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0081161430415983, "mean": 0.2228430358983308, "std": 0.2739052325555903, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1091]}}, "Mrna splicing minor pathway": {"direction": "dw", "overlap": {"value": 19, "mean": 13.5873786407767, "std": 5.472316554100434, "bin": {}}, "setsize": {"value": 33, "mean": 32.04126213592233, "std": 2.337068605999584, "bin": {}}, "score": {"value": -2.6445878501564657, "mean": -0.9003267276000921, "std": 1.0294126267209205, "bin": {}}, "pval": {"value": 0.0081790472339999, "mean": 0.4356302072478651, "std": 0.3422370166243823, "bin": {}}, "signature_idxs": {"edge": [2421, 2627, 2965, 2698, 2594, 2510, 3128, 2355, 2850, 2851, 2590, 2909, 2338, 2747, 2551, 2904, 2761, 2641, 2942], "full": [1474, 2850, 2851, 2747, 659, 2038, 2641, 2698, 2338, 1964, 2204, 1580, 152, 2965, 2421, 1663, 2904, 2054, 2057, 2355, 2761, 2590, 2594, 1750, 3128, 2942, 2909, 1203, 2551, 2235, 242, 2510, 2627]}}, "Hcmv late events": {"direction": "dw", "overlap": {"value": 18, "mean": 10.37135922330097, "std": 5.492311934470012, "bin": {}}, "setsize": {"value": 36, "mean": 35.987864077669904, "std": 2.6961584143216353, "bin": {}}, "score": {"value": -2.6422759330723564, "mean": -0.2604077894188442, "std": 0.7074004247624673, "bin": {}}, "pval": {"value": 0.0082350934291421, "mean": 0.6891915910802267, "std": 0.3052328571555278, "bin": {}}, "signature_idxs": {"edge": [2688, 2528, 2527, 2609, 2781, 2782, 2969, 2639, 2915, 3009, 2805, 2702, 3189, 2676, 2779, 2771, 2773, 2755], "full": [2688, 2639, 2805, 669, 2755, 2702, 2527, 202, 2528, 1662, 1351, 2136, 3189, 2969, 3009, 1601, 2771, 1759, 2231, 2437, 2073, 2773, 268, 2915, 2079, 2609, 2779, 241, 1856, 2781, 2782, 2676, 2306, 2312, 352, 1625]}}, "Dopamine clearance from the synaptic cleft": {"direction": "dw", "overlap": {"value": 1, "mean": 0.2087378640776699, "std": 0.4064066537077882, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -2.640284768474697, "mean": 1.372670814021126, "std": 1.8450353888024225, "bin": {}}, "pval": {"value": 0.0082836390339009, "mean": 0.1400459461927921, "std": 0.2133773995485727, "bin": {}}, "signature_idxs": {"edge": [2039], "full": [2039]}}, "Nicotinamide salvaging": {"direction": "up", "overlap": {"value": 1, "mean": 0.7402912621359223, "std": 0.6918582776345288, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 2}}, "setsize": {"value": 2, "mean": 2.70873786407767, "std": 0.5809444597079318, "bin": {"bin_50": 11, "bin_100": 11, "bin_250": 11, "bin_500": 11}}, "score": {"value": 2.6344799365893805, "mean": 0.2117882492922595, "std": 1.1156750226294163, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 4.340949820788531}}, "pval": {"value": 0.0084266283773191, "mean": 0.5121616586188191, "std": 0.3144655340508403, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.0978216105640502}}, "signature_idxs": {"edge": [267], "full": [255, 267]}}, "Aggrephagy": {"direction": "up", "overlap": {"value": 7, "mean": 5.053398058252427, "std": 3.0019513244173344, "bin": {"bin_50": 0, "bin_100": 1, "bin_250": 5, "bin_500": 8}}, "setsize": {"value": 16, "mean": 15.303398058252426, "std": 1.710245569943332, "bin": {"bin_50": 34, "bin_100": 34, "bin_250": 34, "bin_500": 34}}, "score": {"value": 2.634307583241992, "mean": 0.0176530269767163, "std": 0.9388436016613388, "bin": {"bin_50": 0.0, "bin_100": 3.111935683364255, "bin_250": 7.037746558819356, "bin_500": 6.073469387755102}}, "pval": {"value": 0.0084309074662844, "mean": 0.5860415978812633, "std": 0.3189258517008108, "bin": {"bin_50": 1.0, "bin_100": 0.2827159209662828, "bin_250": 0.0012777259352904, "bin_500": 0.0001802592260071}}, "signature_idxs": {"edge": [143, 103, 302, 93, 270, 236, 169], "full": [169, 401, 1237, 2690, 676, 103, 2135, 302, 1131, 2589, 236, 1676, 270, 93, 143, 1322]}}, "Trafficking of myristoylated proteins to the cilium": {"direction": "up", "overlap": {"value": 0, "mean": 0.3941605839416058, "std": 0.6943392689755551, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 2.43065693430657, "std": 0.6919307635710404, "bin": {"bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 2.6339572187665543, "mean": 0.6471167566325017, "std": 1.3513332069819417, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0084396121034897, "mean": 0.3743256906428743, "std": 0.3016612229286328, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1108]}}, "Activation of anterior hox genes in hindbrain development during early embryogenesis": {"direction": "dw", "overlap": {"value": 11, "mean": 6.827669902912621, "std": 3.240656682787627, "bin": {}}, "setsize": {"value": 20, "mean": 16.41990291262136, "std": 2.80358508181264, "bin": {}}, "score": {"value": -2.6221863650870216, "mean": -0.892377787715027, "std": 0.8379740259056878, "bin": {}}, "pval": {"value": 0.0087367641065898, "mean": 0.4115975474101978, "std": 0.3057839423539609, "bin": {}}, "signature_idxs": {"edge": [2529, 2931, 2338, 2698, 2309, 3214, 2641, 2359, 3004, 2904, 2888], "full": [1474, 2888, 1798, 3214, 2931, 2038, 2641, 2698, 2338, 1658, 2529, 1663, 1351, 2904, 821, 2359, 1904, 3004, 694, 2309]}}, "Nostrin mediated enos trafficking": {"direction": "dw", "overlap": {"value": 1, "mean": 0.3155339805825243, "std": 0.4999528679831163, "bin": {}}, "setsize": {"value": 2, "mean": 1.2014563106796117, "std": 0.4010881020012579, "bin": {}}, "score": {"value": -2.61286060092703, "mean": 0.750117766400549, "std": 1.2988343278454215, "bin": {}}, "pval": {"value": 0.0089787916287953, "mean": 0.3774178172893334, "std": 0.3063366300251974, "bin": {}}, "signature_idxs": {"edge": [3121], "full": [3121, 1415]}}, "Hcmv early events": {"direction": "dw", "overlap": {"value": 22, "mean": 12.46359223300971, "std": 5.833959396627051, "bin": {}}, "setsize": {"value": 47, "mean": 44.35436893203884, "std": 3.0514448813454176, "bin": {}}, "score": {"value": -2.6116080461844007, "mean": -0.2344123619104917, "std": 0.7325989596008913, "bin": {}}, "pval": {"value": 0.0090117506657554, "mean": 0.6821756516237598, "std": 0.2957065288821427, "bin": {}}, "signature_idxs": {"edge": [2528, 2527, 3214, 2805, 2688, 2969, 3009, 2576, 2702, 2779, 3004, 2771, 2589, 2773, 2781, 2782, 2915, 3154, 2676, 2755, 2639, 3189], "full": [169, 1798, 3214, 2688, 401, 2576, 2639, 2805, 669, 2755, 2702, 2527, 202, 2528, 1351, 2135, 302, 2136, 3154, 821, 3189, 1671, 2589, 236, 1676, 2359, 3004, 2969, 3009, 2771, 1759, 2231, 2437, 2073, 2773, 2915, 2079, 270, 2779, 2781, 143, 2782, 2676, 2306, 946, 2312, 1322]}}, "Sumoylation of intracellular receptors": {"direction": "dw", "overlap": {"value": 1, "mean": 0.7258064516129032, "std": 0.7812181315040216, "bin": {}}, "setsize": {"value": 2, "mean": 1.8225806451612905, "std": 1.00039014241682, "bin": {}}, "score": {"value": -2.6089792750152268, "mean": 0.0517796146968343, "std": 1.5747530127345972, "bin": {}}, "pval": {"value": 0.0090812742199164, "mean": 0.393752808894898, "std": 0.3416935301894471, "bin": {}}, "signature_idxs": {"edge": [2931], "full": [1556, 2931]}}, "Rho gtpases activate rhotekin and rhophilins": {"direction": "up", "overlap": {"value": 0, "mean": 0.6755852842809364, "std": 0.5092186045385584, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 2, "mean": 1.1137123745819395, "std": 0.3174616046845294, "bin": {"bin_50": 8, "bin_100": 8, "bin_250": 8, "bin_500": 8}}, "score": {"value": 2.6002583215955783, "mean": -0.5620035126973434, "std": 1.9382686621416747, "bin": {"bin_50": 30.178571428571427, "bin_100": 14.708454810495628, "bin_250": 5.749566223250434, "bin_500": 2.785570566254671}}, "pval": {"value": 0.0093153608550373, "mean": 0.2389590227011943, "std": 0.2820787596668198, "bin": {"bin_50": 0.0378187125466048, "bin_100": 0.075113296023457, "bin_250": 0.1788587842302525, "bin_500": 0.3301808657155594}}, "signature_idxs": {"edge": [], "full": [7, 1969]}}, "Glycosphingolipid metabolism": {"direction": "dw", "overlap": {"value": 11, "mean": 7.514563106796117, "std": 2.3948329397108954, "bin": {}}, "setsize": {"value": 16, "mean": 15.521844660194176, "std": 1.2175929202976112, "bin": {}}, "score": {"value": -2.590468002450929, "mean": 0.6340330218232789, "std": 2.2116324239586063, "bin": {}}, "pval": {"value": 0.0095845531344593, "mean": 0.1371235236408302, "std": 0.2290247571497847, "bin": {}}, "signature_idxs": {"edge": [2763, 2895, 3203, 2308, 2111, 2466, 2673, 2397, 3015, 3092, 2191], "full": [2397, 2111, 2895, 2191, 1401, 1557, 2466, 1879, 3092, 1646, 3203, 2763, 2071, 2673, 3015, 2308]}}, "Tp53 regulates transcription of death receptors and ligands": {"direction": "dw", "overlap": {"value": 1, "mean": 1.1820388349514563, "std": 0.6814944446607741, "bin": {}}, "setsize": {"value": 2, "mean": 2.162621359223301, "std": 0.3690198541375071, "bin": {}}, "score": {"value": -2.589520963405233, "mean": -0.2269906787668598, "std": 0.854017276045707, "bin": {}}, "pval": {"value": 0.0096109570805771, "mean": 0.6513550888123131, "std": 0.3187719167666935, "bin": {}}, "signature_idxs": {"edge": [3022], "full": [3022, 1497]}}, "Ticam1 traf6 dependent induction of tak1 complex": {"direction": "up", "overlap": {"value": 0, "mean": 0.9411764705882352, "std": 0.6389870877176598, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.3689839572192513, "std": 0.4825295809938215, "bin": {"bin_50": 10, "bin_100": 10, "bin_250": 10, "bin_500": 10}}, "score": {"value": 2.584599487610184, "mean": -0.7505963350349926, "std": 1.5918130026823043, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0097492173349422, "mean": 0.3262468297984152, "std": 0.3087659449687511, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1196]}}, "Irak2 mediated activation of tak1 complex": {"direction": "up", "overlap": {"value": 0, "mean": 0.9411764705882352, "std": 0.6389870877176598, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.3689839572192513, "std": 0.4825295809938215, "bin": {"bin_50": 9, "bin_100": 9, "bin_250": 9, "bin_500": 9}}, "score": {"value": 2.584599487610184, "mean": -0.7505963350349926, "std": 1.5918130026823043, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0097492173349422, "mean": 0.3262468297984152, "std": 0.3087659449687511, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1196]}}, "Alpha protein kinase 1 signaling pathway": {"direction": "up", "overlap": {"value": 0, "mean": 0.9411764705882352, "std": 0.6389870877176598, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.3689839572192513, "std": 0.4825295809938215, "bin": {"bin_50": 9, "bin_100": 9, "bin_250": 9, "bin_500": 9}}, "score": {"value": 2.584599487610184, "mean": -0.7505963350349926, "std": 1.5918130026823043, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0097492173349422, "mean": 0.3262468297984152, "std": 0.3087659449687511, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1196]}}, "Regulation of pten gene transcription": {"direction": "dw", "overlap": {"value": 15, "mean": 9.148058252427184, "std": 4.437256337246238, "bin": {}}, "setsize": {"value": 22, "mean": 20.48543689320388, "std": 3.1441549335262615, "bin": {}}, "score": {"value": -2.582864909209221, "mean": -0.6827660637042481, "std": 0.7493113652393069, "bin": {}}, "pval": {"value": 0.0097983681283295, "mean": 0.507538318820083, "std": 0.3061236134367467, "bin": {}}, "signature_idxs": {"edge": [2955, 2434, 3105, 2249, 3116, 2219, 2325, 3214, 2273, 2710, 2342, 2359, 3004, 3022, 2712], "full": [2325, 3214, 1723, 580, 3022, 516, 2342, 821, 2273, 909, 2219, 2359, 3004, 2710, 2712, 2434, 3105, 2075, 1695, 3116, 2249, 2955]}}, "Signaling by tgf beta receptor complex in cancer": {"direction": "up", "overlap": {"value": 0, "mean": 0.3025477707006369, "std": 0.4928080264186791, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 2, "mean": 1.1210191082802548, "std": 0.3261494806240027, "bin": {"bin_50": 8, "bin_100": 8, "bin_250": 8, "bin_500": 8}}, "score": {"value": 2.5817089532447097, "mean": 1.0713765416485823, "std": 1.9560115823637287, "bin": {"bin_50": 30.178571428571427, "bin_100": 14.708454810495628, "bin_250": 5.749566223250434, "bin_500": 2.785570566254671}}, "pval": {"value": 0.0098312456443618, "mean": 0.1610371989586262, "std": 0.2386021436068951, "bin": {"bin_50": 0.0378187125466048, "bin_100": 0.075113296023457, "bin_250": 0.1788587842302525, "bin_500": 0.3301808657155594}}, "signature_idxs": {"edge": [], "full": [31, 1273]}}, "Nuclear pore complex npc disassembly": {"direction": "dw", "overlap": {"value": 23, "mean": 9.718446601941748, "std": 5.013898112844297, "bin": {}}, "setsize": {"value": 31, "mean": 30.0, "std": 1.3528108098986498, "bin": {}}, "score": {"value": -2.563514658235376, "mean": -0.1179329919240803, "std": 0.739873404050116, "bin": {}}, "pval": {"value": 0.010361832543039, "mean": 0.7197112388354925, "std": 0.2993847671619166, "bin": {}}, "signature_idxs": {"edge": [2528, 2527, 2231, 2805, 2688, 2969, 3009, 2702, 2779, 2771, 2773, 2781, 2782, 2915, 2676, 2437, 2755, 2306, 2312, 2639, 3189, 2136, 2402], "full": [2688, 2402, 511, 2639, 726, 2805, 669, 2755, 2702, 2527, 202, 2528, 2136, 3189, 2969, 3009, 2771, 1759, 2231, 2437, 427, 2073, 2773, 2915, 2079, 2779, 2781, 2782, 2676, 2306, 2312]}}, "Transcriptional regulation by runx1": {"direction": "up", "overlap": {"value": 28, "mean": 17.660194174757283, "std": 8.588831535590984, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 11, "bin_500": 21}}, "setsize": {"value": 69, "mean": 67.73058252427184, "std": 5.0191610185934845, "bin": {"bin_50": 149, "bin_100": 149, "bin_250": 149, "bin_500": 149}}, "score": {"value": 2.5512304597809927, "mean": 0.0956433719082077, "std": 0.9164516867594036, "bin": {"bin_50": 1.407516891891892, "bin_100": 2.12992294520548, "bin_250": 3.299394606494221, "bin_500": 3.291568396226415}}, "pval": {"value": 0.0107343319013133, "mean": 0.6467498474297692, "std": 0.3343217460909707, "bin": {"bin_50": 0.5147372580778585, "bin_100": 0.176207393407033, "bin_250": 0.0010143202771897, "bin_500": 1.0795459519771903e-05}}, "signature_idxs": {"edge": [370, 373, 431, 258, 713, 259, 26, 151, 514, 515, 407, 526, 527, 62, 179, 297, 298, 71, 201, 458, 568, 364, 224, 225, 227, 115, 116, 590], "full": [1088, 568, 26, 1024, 3090, 1629, 1630, 958, 651, 2330, 2409, 201, 797, 364, 1040, 590, 115, 407, 224, 514, 515, 458, 225, 370, 373, 1258, 227, 738, 2903, 526, 297, 527, 151, 2529, 814, 298, 179, 1351, 1421, 1051, 116, 258, 2966, 2586, 907, 909, 259, 2358, 912, 1904, 3097, 2064, 2770, 2434, 2547, 71, 2717, 2718, 2293, 770, 2670, 855, 1209, 431, 3116, 1381, 2309, 62, 713]}}, "Pi3k akt activation": {"direction": "dw", "overlap": {"value": 1, "mean": 0.6477272727272727, "std": 0.5547270567026784, "bin": {}}, "setsize": {"value": 1, "mean": 1.2102272727272727, "std": 0.4074699578237954, "bin": {}}, "score": {"value": -2.546860921552504, "mean": -0.2810100148084062, "std": 1.955178569515339, "bin": {}}, "pval": {"value": 0.010869674410205, "mean": 0.2798521039865994, "std": 0.3200976711376496, "bin": {}}, "signature_idxs": {"edge": [1969], "full": [1969]}}, "Er to golgi anterograde transport": {"direction": "up", "overlap": {"value": 21, "mean": 19.152912621359224, "std": 7.637631429097237, "bin": {"bin_50": 1, "bin_100": 3, "bin_250": 11, "bin_500": 19}}, "setsize": {"value": 76, "mean": 74.15776699029126, "std": 6.107600140782552, "bin": {"bin_50": 129, "bin_100": 129, "bin_250": 129, "bin_500": 129}}, "score": {"value": 2.544829350363898, "mean": 0.4357486981835305, "std": 0.9360192475456132, "bin": {"bin_50": 1.6306966145833333, "bin_100": 2.4729662698412698, "bin_250": 3.8664807265965817, "bin_500": 3.457430252419814}}, "pval": {"value": 0.0109331154278993, "mean": 0.6456866134420882, "std": 0.3613336360589621, "bin": {"bin_50": 0.4649456287210195, "bin_100": 0.1301941969243742, "bin_250": 0.0002994424933449, "bin_500": 1.4945847310814127e-05}}, "signature_idxs": {"edge": [143, 8, 127, 302, 191, 401, 51, 284, 296, 55, 169, 608, 202, 234, 236, 474, 578, 385, 217, 465, 270], "full": [955, 284, 789, 1632, 217, 169, 1327, 1872, 127, 874, 1639, 963, 578, 401, 3153, 585, 3199, 1178, 1811, 8, 465, 1044, 1413, 1112, 296, 896, 1740, 1574, 1346, 1187, 202, 1121, 900, 819, 2135, 302, 474, 2269, 234, 1271, 1668, 822, 55, 2589, 608, 2531, 236, 1431, 1676, 1831, 1280, 1433, 993, 1985, 3191, 840, 1442, 385, 1996, 1289, 270, 191, 1929, 143, 1766, 51, 1859, 2387, 942, 1311, 2023, 2741, 1715, 1716, 1322, 1390]}}, "Anchoring of the basal body to the plasma membrane": {"direction": "up", "overlap": {"value": 10, "mean": 10.25, "std": 4.597184131808032, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 4}}, "setsize": {"value": 30, "mean": 32.03398058252427, "std": 4.443147956867209, "bin": {"bin_50": 95, "bin_100": 95, "bin_250": 95, "bin_500": 95}}, "score": {"value": 2.542798995976617, "mean": 0.6177589631738116, "std": 0.9752582334781768, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.4244120940649496, "bin_500": 0.8548293811451706}}, "pval": {"value": 0.0109968469915819, "mean": 0.4929072994149106, "std": 0.3486333170600847, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.9046558347203958, "bin_500": 0.6886064916318076}}, "signature_idxs": {"edge": [511, 702, 608, 621, 665, 302, 401, 127, 402, 538], "full": [127, 1097, 401, 511, 402, 1237, 1403, 665, 730, 1342, 1818, 1501, 1121, 1122, 1579, 2135, 302, 2589, 608, 1748, 1431, 1676, 1678, 1833, 538, 1515, 1287, 621, 702, 1465]}}, "Gdp fucose biosynthesis": {"direction": "up", "overlap": {"value": 1, "mean": 0.7492447129909365, "std": 0.6507892284556193, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 2}}, "setsize": {"value": 2, "mean": 1.4531722054380665, "std": 0.6410531581812613, "bin": {"bin_50": 6, "bin_100": 6, "bin_250": 6, "bin_500": 6}}, "score": {"value": 2.538175583637688, "mean": -0.1945775493560761, "std": 1.5861354758716264, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 9.772177419354838}}, "pval": {"value": 0.0111432062075411, "mean": 0.3770312018649642, "std": 0.325496682515789, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.0313283564047791}}, "signature_idxs": {"edge": [285], "full": [285, 325]}}, "Prc2 methylates histones and dna": {"direction": "dw", "overlap": {"value": 4, "mean": 2.837378640776699, "std": 1.4632258956428108, "bin": {}}, "setsize": {"value": 8, "mean": 5.762135922330097, "std": 1.3516345016998177, "bin": {}}, "score": {"value": -2.538058157093594, "mean": -0.9701380845220736, "std": 0.9407741030308838, "bin": {}}, "pval": {"value": 0.0111469458986175, "mean": 0.336816503305555, "std": 0.291766863324607, "bin": {}}, "signature_idxs": {"edge": [3004, 3151, 3214, 3108], "full": [3214, 1339, 1351, 821, 2359, 3004, 3108, 3151]}}, "Activation of nmda receptors and postsynaptic events": {"direction": "up", "overlap": {"value": 8, "mean": 6.531553398058253, "std": 3.686958716509548, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 6, "bin_500": 8}}, "setsize": {"value": 25, "mean": 22.640776699029125, "std": 3.4007548246413095, "bin": {"bin_50": 68, "bin_100": 68, "bin_250": 68, "bin_500": 68}}, "score": {"value": 2.530545840676027, "mean": 0.202717901626862, "std": 0.9825513888915872, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 3.953345774460144, "bin_500": 2.6225850340136057}}, "pval": {"value": 0.0113885202331847, "mean": 0.5678584679324417, "std": 0.3302803464124077, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0060584295805293, "bin_500": 0.0172408232976174}}, "signature_idxs": {"edge": [143, 302, 401, 188, 100, 220, 201, 236], "full": [1164, 1726, 401, 220, 201, 1483, 1403, 516, 730, 100, 1345, 1500, 1966, 904, 302, 1429, 1430, 1275, 236, 3186, 1355, 2278, 188, 143, 1538]}}, "Cooperation of pdcl phlp1 and tric cct in g protein beta folding": {"direction": "up", "overlap": {"value": 8, "mean": 6.334951456310679, "std": 3.1421719264100174, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 4}}, "setsize": {"value": 12, "mean": 12.04126213592233, "std": 1.4093124259045722, "bin": {"bin_50": 27, "bin_100": 27, "bin_250": 27, "bin_500": 27}}, "score": {"value": 2.528092362486804, "mean": -0.3771213038586288, "std": 0.7983609431504407, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 3.406090477028692}}, "pval": {"value": 0.0114684177207977, "mean": 0.5715949221250719, "std": 0.3041883117429877, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.0404595824929281}}, "signature_idxs": {"edge": [733, 662, 775, 364, 530, 376, 466, 294], "full": [662, 364, 733, 294, 466, 376, 895, 1822, 1504, 1421, 530, 775]}}, "Erythropoietin activates phospholipase c gamma plcg": {"direction": "up", "overlap": {"value": 0, "mean": 0.8151041666666666, "std": 0.64119110319465, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 2, "mean": 1.4348958333333333, "std": 0.4957433282280648, "bin": {"bin_50": 5, "bin_100": 5, "bin_250": 5, "bin_500": 5}}, "score": {"value": 2.519888194388325, "mean": -0.3462586408565656, "std": 1.574271747165371, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 10.064777327935223, "bin_500": 4.8762575452716295}}, "pval": {"value": 0.0117392115774772, "mean": 0.4075057548715118, "std": 0.3507997346928889, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1158638926054548, "bin_500": 0.2215335762210877}}, "signature_idxs": {"edge": [], "full": [219, 1485]}}, "Protein repair": {"direction": "up", "overlap": {"value": 0, "mean": 0.4599483204134367, "std": 0.4983932814176925, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 5, "bin_100": 5, "bin_250": 5, "bin_500": 5}}, "score": {"value": 2.519645843003356, "mean": 0.0584904466420277, "std": 1.745135752885273, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0117472963667055, "mean": 0.2830905333953791, "std": 0.2795664038079568, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1175]}}, "Antimicrobial peptides": {"direction": "dw", "overlap": {"value": 2, "mean": 1.1310679611650485, "std": 0.7421471246353926, "bin": {}}, "setsize": {"value": 2, "mean": 2.470873786407767, "std": 0.7013345209553864, "bin": {}}, "score": {"value": -2.51124920614056, "mean": -0.8331527803686477, "std": 1.3237154315007764, "bin": {}}, "pval": {"value": 0.0120304735253982, "mean": 0.3358159971999788, "std": 0.3004912337621939, "bin": {}}, "signature_idxs": {"edge": [3211, 2876], "full": [3211, 2876]}}, "Membrane trafficking": {"direction": "up", "overlap": {"value": 87, "mean": 58.74029126213592, "std": 20.641367360645177, "bin": {"bin_50": 3, "bin_100": 7, "bin_250": 21, "bin_500": 42}}, "setsize": {"value": 234, "mean": 242.25485436893203, "std": 25.09710463183197, "bin": {"bin_50": 532, "bin_100": 532, "bin_250": 532, "bin_500": 532}}, "score": {"value": 2.502396164657616, "mean": 0.106669218097389, "std": 0.815267726548191, "bin": {"bin_50": 1.1857483356620366, "bin_100": 1.387246376811594, "bin_250": 1.7084665982740932, "bin_500": 1.7308270676691728}}, "pval": {"value": 0.0123355804430742, "mean": 0.776311264496784, "std": 0.3198694723134335, "bin": {"bin_50": 0.47473609540979, "bin_100": 0.2582842425912988, "bin_250": 0.0195101462829468, "bin_500": 0.001348316785662}}, "signature_idxs": {"edge": [0, 539, 6, 551, 8, 518, 51, 55, 75, 608, 85, 578, 111, 107, 585, 599, 143, 587, 127, 160, 677, 194, 657, 191, 647, 646, 675, 169, 766, 762, 201, 202, 756, 234, 786, 236, 241, 217, 268, 270, 745, 734, 840, 302, 283, 284, 295, 296, 787, 352, 790, 789, 819, 822, 812, 385, 390, 933, 942, 911, 437, 441, 442, 443, 870, 874, 900, 906, 904, 401, 415, 896, 993, 504, 1021, 505, 987, 962, 475, 474, 963, 956, 955, 473, 467, 465, 548], "full": [870, 2745, 283, 2184, 787, 2107, 3121, 2398, 1090, 955, 284, 2454, 956, 789, 1717, 790, 1632, 2887, 217, 169, 1229, 1549, 646, 2989, 647, 1871, 1327, 1872, 127, 2258, 874, 2635, 1639, 2990, 1641, 962, 963, 578, 2572, 2575, 401, 3153, 1558, 2517, 657, 2333, 1806, 201, 2335, 585, 1648, 1244, 1960, 587, 3199, 3166, 970, 518, 2700, 1493, 1251, 85, 1568, 1178, 734, 0, 1342, 1811, 8, 465, 1044, 1413, 1112, 2808, 599, 1415, 1260, 1261, 1815, 1738, 295, 1817, 296, 896, 1740, 1574, 675, 1346, 1500, 1966, 1187, 202, 1049, 677, 467, 1501, 1120, 2134, 1502, 1577, 812, 1121, 745, 900, 1122, 1579, 415, 819, 1266, 904, 2052, 2348, 2135, 302, 473, 1823, 474, 1824, 2269, 2352, 3155, 1269, 2966, 475, 234, 1975, 1899, 1746, 3027, 1271, 1668, 822, 2759, 906, 55, 2589, 987, 608, 2531, 236, 1431, 1676, 911, 1749, 1677, 1831, 1903, 1981, 1278, 1593, 756, 1195, 1280, 1433, 1061, 539, 993, 1985, 762, 1136, 160, 3191, 1601, 2229, 1913, 840, 1442, 385, 2290, 1849, 1445, 268, 1996, 1289, 1371, 766, 1292, 2000, 1206, 270, 2609, 191, 2003, 548, 933, 1929, 241, 107, 1856, 551, 143, 1766, 1703, 1211, 3038, 390, 2090, 51, 1859, 1860, 1616, 1770, 2387, 1535, 437, 6, 1777, 111, 75, 942, 1863, 1311, 1781, 441, 2023, 194, 442, 2984, 2025, 352, 2953, 443, 2741, 1625, 1387, 1715, 786, 1320, 504, 1021, 1716, 1322, 505, 1390]}}, "Purine ribonucleoside monophosphate biosynthesis": {"direction": "up", "overlap": {"value": 8, "mean": 5.609223300970874, "std": 2.4976129144695394, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 2}}, "setsize": {"value": 10, "mean": 9.57766990291262, "std": 0.4988203635714793, "bin": {"bin_50": 11, "bin_100": 11, "bin_250": 11, "bin_500": 11}}, "score": {"value": 2.489969474374715, "mean": -0.5956690698419117, "std": 1.0719792910136363, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 4.023481781376519, "bin_500": 4.340949820788531}}, "pval": {"value": 0.0127754067317251, "mean": 0.4049019913941552, "std": 0.3162446040890186, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.2373820829012167, "bin_500": 0.0978216105640502}}, "signature_idxs": {"edge": [667, 798, 253, 683, 586, 727, 228, 593], "full": [1547, 253, 727, 586, 798, 593, 890, 667, 228, 683]}}, "Interconversion of nucleotide di and triphosphates": {"direction": "up", "overlap": {"value": 8, "mean": 5.497572815533981, "std": 3.6513721229998217, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 3, "bin_500": 6}}, "setsize": {"value": 18, "mean": 17.694174757281555, "std": 1.854845412275771, "bin": {"bin_50": 26, "bin_100": 26, "bin_250": 26, "bin_500": 26}}, "score": {"value": 2.4775252593509305, "mean": -0.1681971791529782, "std": 1.091743890900105, "bin": {"bin_50": 8.435, "bin_100": 4.111020408163266, "bin_250": 5.28393966282165, "bin_500": 5.901219512195122}}, "pval": {"value": 0.0132297044024081, "mean": 0.4897251001051131, "std": 0.3245015655397826, "bin": {"bin_50": 0.1178616319260966, "bin_100": 0.2243071172363204, "bin_250": 0.0244664942800011, "bin_500": 0.0013134629127741}}, "signature_idxs": {"edge": [347, 148, 4, 517, 559, 366, 221, 334], "full": [716, 148, 876, 221, 1335, 2414, 366, 1246, 517, 519, 1250, 1177, 2756, 334, 916, 347, 559, 4]}}, "Ampk inhibits chrebp transcriptional activation activity": {"direction": "dw", "overlap": {"value": 1, "mean": 0.2387387387387387, "std": 0.4263127412641745, "bin": {}}, "setsize": {"value": 1, "mean": 1.0045045045045045, "std": 0.0669642736365698, "bin": {}}, "score": {"value": -2.471797017045436, "mean": 0.9167308967271652, "std": 1.6646421672251737, "bin": {}}, "pval": {"value": 0.0134435824086138, "mean": 0.2439015980607041, "std": 0.265434986271383, "bin": {}}, "signature_idxs": {"edge": [1966], "full": [1966]}}, "Mitotic telophase cytokinesis": {"direction": "dw", "overlap": {"value": 7, "mean": 5.779126213592233, "std": 3.174114235222936, "bin": {}}, "setsize": {"value": 11, "mean": 11.990291262135925, "std": 1.09938328370353, "bin": {}}, "score": {"value": -2.4615211380681123, "mean": -0.3391211269248221, "std": 0.8334900936976168, "bin": {}}, "pval": {"value": 0.0138349245016335, "mean": 0.5655724867640047, "std": 0.3166450314450013, "bin": {}}, "signature_idxs": {"edge": [3137, 2990, 2562, 2912, 2734, 2707, 3155], "full": [1946, 2990, 1818, 3155, 2707, 1907, 3137, 921, 2912, 2734, 2562]}}, "Resolution of ap sites via the multiple nucleotide patch replacement pathway": {"direction": "up", "overlap": {"value": 13, "mean": 7.691747572815534, "std": 4.105363512205524, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 3, "bin_500": 7}}, "setsize": {"value": 24, "mean": 21.0995145631068, "std": 2.424050160748896, "bin": {"bin_50": 28, "bin_100": 28, "bin_250": 28, "bin_500": 28}}, "score": {"value": 2.454763445774223, "mean": -0.3466659118659361, "std": 1.0608179313016342, "bin": {"bin_50": 7.808641975308642, "bin_100": 3.805744520030234, "bin_250": 4.860244897959183, "bin_500": 6.569585879158181}}, "pval": {"value": 0.0140977323662463, "mean": 0.4922744727209283, "std": 0.3301803369974565, "bin": {"bin_50": 0.1263420182810564, "bin_100": 0.239336332644921, "bin_250": 0.029757296929711, "bin_500": 0.0003070198717132}}, "signature_idxs": {"edge": [607, 369, 990, 560, 252, 130, 329, 729, 21, 173, 292, 591, 805], "full": [1099, 252, 1242, 1104, 591, 173, 729, 21, 329, 369, 2043, 130, 292, 1496, 805, 2419, 607, 990, 1602, 2015, 2305, 560, 1016, 2790]}}, "Global genome nucleotide excision repair gg ner": {"direction": "up", "overlap": {"value": 26, "mean": 11.189320388349516, "std": 5.564980876830327, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 2, "bin_500": 9}}, "setsize": {"value": 45, "mean": 40.220873786407765, "std": 4.663663630644719, "bin": {"bin_50": 87, "bin_100": 87, "bin_250": 87, "bin_500": 87}}, "score": {"value": 2.4525825403922217, "mean": -0.0293185639996807, "std": 0.8290459263699445, "bin": {"bin_50": 2.437257751937985, "bin_100": 1.1878262933080208, "bin_250": 0.94337637494022, "bin_500": 2.2699386503067487}}, "pval": {"value": 0.0141834835118908, "mean": 0.6573141735030886, "std": 0.3081143430091423, "bin": {"bin_50": 0.343540942585206, "bin_100": 0.5736475606118113, "bin_250": 0.6292234985975467, "bin_500": 0.02573018430516}}, "signature_idxs": {"edge": [369, 745, 551, 252, 21, 424, 443, 444, 906, 1039, 292, 618, 805, 607, 990, 766, 762, 1016, 329, 603, 1104, 1103, 103, 729, 591, 548], "full": [1556, 2330, 1099, 252, 1242, 1103, 1104, 1039, 1404, 591, 729, 21, 329, 369, 2043, 292, 1496, 805, 1813, 1967, 2419, 103, 745, 603, 607, 906, 2061, 2480, 990, 1197, 762, 424, 618, 766, 548, 551, 1770, 2015, 2305, 1781, 1016, 2679, 443, 444, 2790]}}, "Ptk6 regulates proteins involved in rna processing": {"direction": "dw", "overlap": {"value": 1, "mean": 1.1383495145631068, "std": 0.6986708561391486, "bin": {}}, "setsize": {"value": 2, "mean": 2.3907766990291264, "std": 0.4879244516572478, "bin": {}}, "score": {"value": -2.452211117889498, "mean": 0.6718565754956202, "std": 0.9773328389973504, "bin": {}}, "pval": {"value": 0.0141981332697711, "mean": 0.4615860446789395, "std": 0.3019299313975543, "bin": {}}, "signature_idxs": {"edge": [3042], "full": [3042, 1425]}}, "The citric acid tca cycle and respiratory electron transport": {"direction": "dw", "overlap": {"value": 37, "mean": 27.99757281553398, "std": 12.60942373482268, "bin": {}}, "setsize": {"value": 85, "mean": 94.17961165048544, "std": 7.020896123249261, "bin": {}}, "score": {"value": -2.4458648310744, "mean": 0.4883573568636233, "std": 1.7895370613076145, "bin": {}}, "pval": {"value": 0.0144505165035822, "mean": 0.4259472248586306, "std": 0.38969273744301, "bin": {}}, "signature_idxs": {"edge": [2927, 2602, 3078, 2801, 2611, 2795, 2686, 2578, 2883, 2569, 2190, 2196, 2699, 2587, 2580, 2198, 2772, 2332, 2860, 2205, 2164, 2183, 2914, 3146, 2177, 2169, 3058, 2893, 2122, 2898, 2538, 2114, 2267, 2262, 2261, 2126, 2525], "full": [2927, 1028, 1476, 170, 1167, 2686, 2569, 1477, 2114, 1397, 1170, 1555, 1096, 2795, 2190, 1949, 2037, 1800, 2893, 400, 1235, 3146, 718, 1644, 3078, 1728, 2578, 1729, 2332, 1880, 2898, 1882, 2122, 1486, 1562, 2801, 1488, 1337, 2261, 2196, 2699, 2198, 1886, 972, 1253, 1963, 2580, 2126, 2262, 2525, 1411, 735, 1184, 1812, 976, 1890, 1115, 1344, 1819, 2267, 2205, 1665, 1352, 2587, 2860, 1279, 2538, 758, 1682, 1910, 1514, 2602, 2914, 2772, 1763, 2611, 2084, 2164, 2169, 1383, 2883, 2177, 440, 2183, 3058]}}, "Activation of the pre replicative complex": {"direction": "up", "overlap": {"value": 8, "mean": 5.689320388349515, "std": 4.264391114445643, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 2, "bin_500": 3}}, "setsize": {"value": 21, "mean": 20.37864077669903, "std": 3.0060343997875663, "bin": {"bin_50": 33, "bin_100": 33, "bin_250": 33, "bin_500": 33}}, "score": {"value": 2.434690920970455, "mean": 0.257943935461773, "std": 0.8125565328981424, "bin": {"bin_50": 6.585286458333333, "bin_100": 3.209502551020408, "bin_250": 2.600839234198794, "bin_500": 1.953131313131313}}, "pval": {"value": 0.0149045147126316, "mean": 0.622644435072912, "std": 0.3151513491599574, "bin": {"bin_50": 0.1471951297158956, "bin_100": 0.2756599666896902, "bin_250": 0.1911341037783432, "bin_500": 0.2168926648719501}}, "signature_idxs": {"edge": [607, 570, 731, 131, 21, 260, 591, 589], "full": [1796, 570, 1482, 1242, 589, 1489, 591, 731, 1407, 1252, 21, 737, 131, 1186, 2419, 607, 260, 1591, 2015, 2305, 1156]}}, "Notch3 activation and transmission of signal to the nucleus": {"direction": "dw", "overlap": {"value": 1, "mean": 0.9053398058252428, "std": 0.8466212866321063, "bin": {}}, "setsize": {"value": 1, "mean": 3.0097087378640777, "std": 0.7567835056273816, "bin": {}}, "score": {"value": -2.4330593423832143, "mean": 0.4688775257688064, "std": 0.9929684234958204, "bin": {}}, "pval": {"value": 0.0149718469006372, "mean": 0.5171165781834446, "std": 0.3174443949635189, "bin": {}}, "signature_idxs": {"edge": [2030], "full": [2030]}}, "Post chaperonin tubulin folding pathway": {"direction": "up", "overlap": {"value": 4, "mean": 4.631067961165049, "std": 2.528441291450786, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 3, "bin_500": 5}}, "setsize": {"value": 9, "mean": 9.669902912621358, "std": 1.207889513967516, "bin": {"bin_50": 18, "bin_100": 18, "bin_250": 18, "bin_500": 18}}, "score": {"value": 2.428564425873851, "mean": 0.1824952152215168, "std": 1.0855078483623932, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 8.108571428571429, "bin_500": 7.555780933062881}}, "pval": {"value": 0.0151587316184458, "mean": 0.5047249093477747, "std": 0.3264088774408823, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0088528623379573, "bin_500": 0.0013736729067174}}, "signature_idxs": {"edge": [143, 208, 236, 302], "full": [1552, 401, 1254, 302, 236, 757, 208, 1531, 143]}}, "Mitotic prophase": {"direction": "dw", "overlap": {"value": 31, "mean": 16.02912621359223, "std": 6.700900259296581, "bin": {}}, "setsize": {"value": 60, "mean": 59.02427184466019, "std": 3.548470640609209, "bin": {}}, "score": {"value": -2.426762478008265, "mean": -0.2058533657804895, "std": 0.7017004743356385, "bin": {}}, "pval": {"value": 0.0152342259743936, "mean": 0.7117944115225756, "std": 0.3033960676867108, "bin": {}}, "signature_idxs": {"edge": [2528, 2527, 2409, 3213, 2805, 2688, 2958, 2960, 2969, 3009, 2702, 2779, 2771, 2773, 2781, 2782, 2915, 3157, 2676, 3029, 2437, 2755, 2316, 2306, 2312, 2639, 2263, 2450, 3189, 2526, 2402], "full": [1327, 2958, 2688, 2402, 1642, 2960, 2409, 1955, 511, 2639, 726, 3213, 516, 665, 1566, 2805, 669, 1734, 2046, 2263, 2755, 2702, 2526, 2527, 1818, 202, 2528, 1419, 1351, 819, 2136, 234, 3189, 3029, 2969, 3009, 1912, 2771, 3157, 1759, 2231, 2437, 427, 2073, 2773, 2915, 2079, 240, 2779, 209, 2781, 2782, 2676, 51, 1078, 2306, 1776, 2312, 2450, 2316]}}, "Ticam1 dependent activation of irf3 irf7": {"direction": "up", "overlap": {"value": 0, "mean": 0.5051546391752577, "std": 0.4999734289889543, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 10, "bin_100": 10, "bin_250": 10, "bin_500": 10}}, "score": {"value": 2.421345781921061, "mean": -0.0123684241620878, "std": 1.9712664516697769, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0154631606552602, "mean": 0.1979586034997871, "std": 0.2389432871756055, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1314]}}, "Cholesterol biosynthesis": {"direction": "dw", "overlap": {"value": 8, "mean": 5.878640776699029, "std": 2.503362805703168, "bin": {}}, "setsize": {"value": 15, "mean": 16.75, "std": 1.8986773628384943, "bin": {}}, "score": {"value": -2.42090564260954, "mean": 1.3996798653689082, "std": 1.0886216368414, "bin": {}}, "pval": {"value": 0.0154818953122433, "mean": 0.2350718901934974, "std": 0.270950573691616, "bin": {}}, "signature_idxs": {"edge": [3057, 2793, 2936, 2815, 2813, 2941, 2754, 2940], "full": [2793, 404, 2754, 2936, 1267, 1505, 1588, 2940, 2813, 829, 2941, 2221, 2815, 491, 3057]}}, "Rna polymerase ii transcribes snrna genes": {"direction": "dw", "overlap": {"value": 12, "mean": 8.79611650485437, "std": 4.490246654199837, "bin": {}}, "setsize": {"value": 28, "mean": 25.689320388349515, "std": 5.686432714264379, "bin": {}}, "score": {"value": -2.4180609098001686, "mean": -0.5762784826700958, "std": 0.7365854930202712, "bin": {}}, "pval": {"value": 0.0156034646824918, "mean": 0.5625281359422962, "std": 0.3011196320058045, "bin": {}}, "signature_idxs": {"edge": [3107, 2863, 2582, 2338, 2698, 3035, 3182, 2641, 2452, 2355, 2904, 2970], "full": [2452, 1474, 659, 2038, 2641, 2698, 2338, 2202, 1113, 1964, 2582, 1663, 2904, 2355, 1434, 1753, 1684, 2970, 2863, 3035, 3107, 1002, 1296, 1613, 555, 1775, 1215, 3182]}}, "Signaling by leptin": {"direction": "up", "overlap": {"value": 1, "mean": 1.1067961165048543, "std": 0.6670121956239872, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 2}}, "setsize": {"value": 2, "mean": 1.9053398058252424, "std": 0.3459482972032474, "bin": {"bin_50": 8, "bin_100": 8, "bin_250": 8, "bin_500": 8}}, "score": {"value": 2.417706100981268, "mean": -0.4140975730223527, "std": 1.236539784791401, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 5.749566223250434, "bin_500": 6.513440860215054}}, "pval": {"value": 0.0156186861604807, "mean": 0.5209274456260546, "std": 0.3400760802849544, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1788587842302525, "bin_500": 0.0548161530025184}}, "signature_idxs": {"edge": [116], "full": [409, 116]}}, "Synthesis of dolichyl phosphate": {"direction": "dw", "overlap": {"value": 1, "mean": 0.525, "std": 0.6186342484322488, "bin": {}}, "setsize": {"value": 1, "mean": 1.6694444444444445, "std": 0.6865046105066692, "bin": {}}, "score": {"value": -2.417518061036211, "mean": 0.5233899375810995, "std": 1.746200203954798, "bin": {}}, "pval": {"value": 0.0156267584647871, "mean": 0.3479783848098225, "std": 0.339940279844701, "bin": {}}, "signature_idxs": {"edge": [1992], "full": [1992]}}, "Regulation of plk1 activity at g2 m transition": {"direction": "up", "overlap": {"value": 12, "mean": 10.817961165048544, "std": 5.051517864598315, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 2, "bin_500": 5}}, "setsize": {"value": 35, "mean": 36.351941747572816, "std": 4.566118480415196, "bin": {"bin_50": 87, "bin_100": 87, "bin_250": 87, "bin_500": 87}}, "score": {"value": 2.4152129297226805, "mean": 0.4236275579912321, "std": 0.8709022927963019, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.94337637494022, "bin_500": 1.1893335971899273}}, "pval": {"value": 0.0157260133895236, "mean": 0.5790160572388595, "std": 0.3353187527061693, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.6292234985975467, "bin_500": 0.4211059834024279}}, "signature_idxs": {"edge": [511, 702, 608, 621, 665, 181, 302, 401, 127, 402, 726, 538], "full": [1165, 1945, 127, 1097, 2402, 401, 511, 402, 1237, 726, 1403, 665, 730, 1342, 1818, 1501, 1121, 1122, 2207, 1579, 2135, 181, 302, 2589, 608, 1057, 1748, 1431, 1676, 1833, 538, 1515, 621, 702, 1465]}}, "Extension of telomeres": {"direction": "up", "overlap": {"value": 21, "mean": 10.99514563106796, "std": 5.459024391673725, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 4, "bin_500": 11}}, "setsize": {"value": 33, "mean": 29.817961165048544, "std": 3.3737087020456933, "bin": {"bin_50": 52, "bin_100": 52, "bin_250": 52, "bin_500": 52}}, "score": {"value": 2.413374748694919, "mean": -0.5527105605552829, "std": 0.9287603373429604, "bin": {"bin_50": 4.124183006535947, "bin_100": 2.0100040016006404, "bin_250": 3.3811475409836067, "bin_500": 5.320128211549056}}, "pval": {"value": 0.0158055592523282, "mean": 0.5213069266798682, "std": 0.3370195569162178, "bin": {"bin_50": 0.2220822570468345, "bin_100": 0.3986935444378103, "bin_250": 0.0372180748890915, "bin_500": 3.29646854280017e-05}}, "signature_idxs": {"edge": [369, 737, 252, 130, 563, 131, 21, 260, 162, 444, 292, 805, 993, 990, 495, 1013, 329, 777, 729, 591, 589], "full": [955, 2458, 1482, 252, 1242, 1104, 589, 591, 729, 21, 329, 369, 2043, 130, 292, 1496, 805, 737, 131, 2581, 260, 990, 3190, 993, 162, 777, 495, 1013, 2787, 1467, 563, 444, 2790]}}, "Loss of function of smad2 3 in cancer": {"direction": "up", "overlap": {"value": 0, "mean": 0.6, "std": 0.4898979485566356, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 7, "bin_100": 7, "bin_250": 7, "bin_500": 7}}, "score": {"value": 2.39223569344215, "mean": -0.6240157174744254, "std": 2.190078590375012, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0167460846236542, "mean": 0.1580065570839669, "std": 0.223313100566275, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1273]}}, "Foxo mediated transcription of cell cycle genes": {"direction": "up", "overlap": {"value": 0, "mean": 0.5882352941176471, "std": 0.4921529567847503, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 13, "bin_100": 13, "bin_250": 13, "bin_500": 13}}, "score": {"value": 2.39223569344215, "mean": -0.6188741661583208, "std": 2.225552916494695, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0167460846236542, "mean": 0.1324942503581624, "std": 0.1938608603682174, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1273]}}, "Runx3 regulates bcl2l11 bim transcription": {"direction": "up", "overlap": {"value": 0, "mean": 0.5882352941176471, "std": 0.4921529567847503, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 5, "bin_100": 5, "bin_250": 5, "bin_500": 5}}, "score": {"value": 2.39223569344215, "mean": -0.6188741661583208, "std": 2.225552916494695, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0167460846236542, "mean": 0.1324942503581624, "std": 0.1938608603682174, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1273]}}, "Toll like receptor cascades": {"direction": "up", "overlap": {"value": 8, "mean": 7.165048543689321, "std": 4.038881627810941, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 4, "bin_500": 7}}, "setsize": {"value": 25, "mean": 27.33009708737864, "std": 4.339675504656963, "bin": {"bin_50": 103, "bin_100": 103, "bin_250": 103, "bin_500": 103}}, "score": {"value": 2.389394491873049, "mean": -0.2468232617077198, "std": 0.9129292880958944, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 1.6308991554893195, "bin_500": 1.425958927359131}}, "pval": {"value": 0.0168761704141038, "mean": 0.5651419273555431, "std": 0.3127827796055167, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.2416602845663173, "bin_500": 0.2379124225625916}}, "signature_idxs": {"edge": [136, 181, 103, 251, 256, 116, 304, 535], "full": [1225, 2119, 251, 2470, 516, 665, 1566, 1415, 256, 103, 181, 304, 116, 1131, 535, 1057, 1592, 2812, 2278, 1196, 2488, 136, 1378, 2084, 1314]}}, "Hcmv infection": {"direction": "dw", "overlap": {"value": 23, "mean": 14.00485436893204, "std": 6.684279174719419, "bin": {}}, "setsize": {"value": 55, "mean": 52.817961165048544, "std": 4.338623972998164, "bin": {}}, "score": {"value": -2.387985707004351, "mean": -0.2385386853821961, "std": 0.6896725732682144, "bin": {}}, "pval": {"value": 0.01694100062145, "mean": 0.6894872485949345, "std": 0.2915139648437624, "bin": {}}, "signature_idxs": {"edge": [2528, 2527, 2609, 3214, 2805, 2688, 2969, 3009, 2576, 2702, 2779, 3004, 2771, 2589, 2773, 2781, 2782, 2915, 3154, 2676, 2755, 2639, 3189], "full": [169, 1798, 3214, 2688, 401, 2576, 2639, 2805, 669, 2755, 2702, 2527, 202, 2528, 1662, 1351, 2135, 302, 2136, 3154, 821, 3189, 1671, 2589, 236, 1676, 2359, 3004, 2969, 3009, 1601, 2771, 1759, 2231, 2437, 2073, 2773, 268, 2915, 2079, 270, 2609, 2779, 241, 1856, 2781, 143, 2782, 2676, 2306, 946, 2312, 352, 1625, 1322]}}, "Translesion synthesis by polk": {"direction": "up", "overlap": {"value": 5, "mean": 3.3470873786407767, "std": 2.505995967371352, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 5}}, "setsize": {"value": 9, "mean": 9.37135922330097, "std": 0.8007612258729394, "bin": {"bin_50": 17, "bin_100": 17, "bin_250": 17, "bin_500": 17}}, "score": {"value": 2.382411296513427, "mean": -0.1131345586034362, "std": 0.8969053891262133, "bin": {"bin_50": 13.19140625, "bin_100": 6.4292091836734695, "bin_250": 2.513157894736842, "bin_500": 8.186274509803921}}, "pval": {"value": 0.0171996751491008, "mean": 0.5425768181247159, "std": 0.2964293686004159, "bin": {"bin_50": 0.0786913117950012, "bin_100": 0.152955667850895, "bin_250": 0.3422564852890665, "bin_500": 0.0010331595236533}}, "signature_idxs": {"edge": [369, 252, 329, 21, 292], "full": [252, 1242, 591, 21, 329, 369, 2043, 292, 1496]}}, "Oxidative stress induced senescence": {"direction": "dw", "overlap": {"value": 5, "mean": 4.968446601941747, "std": 2.8010876033626215, "bin": {}}, "setsize": {"value": 15, "mean": 14.237864077669904, "std": 3.073014917073174, "bin": {}}, "score": {"value": -2.374105105168792, "mean": -0.5849219068611028, "std": 0.7802215620558174, "bin": {}}, "pval": {"value": 0.0175915421340528, "mean": 0.5170208901361618, "std": 0.2952989662346496, "bin": {}}, "signature_idxs": {"edge": [3116, 3214, 3004, 3022, 2932], "full": [3214, 2932, 3022, 1241, 516, 802, 1351, 1051, 821, 2359, 3004, 2488, 2434, 3116, 1381]}}, "E2f mediated regulation of dna replication": {"direction": "up", "overlap": {"value": 6, "mean": 3.487864077669903, "std": 2.582117047607358, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 2}}, "setsize": {"value": 12, "mean": 10.79368932038835, "std": 1.751187940927259, "bin": {"bin_50": 23, "bin_100": 23, "bin_250": 23, "bin_500": 23}}, "score": {"value": 2.373310881664053, "mean": 0.3292996576377281, "std": 0.8173260414536428, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 1.826647037173353, "bin_500": 1.8581029185867897}}, "pval": {"value": 0.0176294185581826, "mean": 0.5802031533266916, "std": 0.3067170139452786, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.4327587673805496, "bin_500": 0.3106281566010752}}, "signature_idxs": {"edge": [511, 665, 570, 131, 726, 260], "full": [1796, 570, 1955, 511, 1482, 726, 665, 1566, 737, 131, 260, 1156]}}, "Plasma lipoprotein assembly": {"direction": "dw", "overlap": {"value": 1, "mean": 1.0728155339805825, "std": 0.8387107738003564, "bin": {}}, "setsize": {"value": 2, "mean": 2.7888349514563107, "std": 0.8134617396566306, "bin": {}}, "score": {"value": -2.370691894472304, "mean": 0.0649519673394093, "std": 0.9231145665716884, "bin": {}}, "pval": {"value": 0.0177548247032897, "mean": 0.5997601989146661, "std": 0.3134852938250059, "bin": {}}, "signature_idxs": {"edge": [2993], "full": [2993, 1403]}}, "Diseases associated with o glycosylation of proteins": {"direction": "up", "overlap": {"value": 0, "mean": 0.4174757281553398, "std": 0.5956846732906611, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.5218446601941749, "std": 0.6129734113760651, "bin": {"bin_50": 17, "bin_100": 17, "bin_250": 17, "bin_500": 17}}, "score": {"value": 2.3571849736282, "mean": 0.9800294130852574, "std": 1.742276704521334, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0184140718864076, "mean": 0.2589966371269667, "std": 0.3065542429149289, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1230]}}, "Keratan sulfate biosynthesis": {"direction": "up", "overlap": {"value": 0, "mean": 0.4101941747572815, "std": 0.5946304728058994, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.3349514563106797, "std": 0.6266273939490626, "bin": {"bin_50": 11, "bin_100": 11, "bin_250": 11, "bin_500": 11}}, "score": {"value": 2.3571849736282, "mean": 1.163530760409998, "std": 1.912288808565062, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0184140718864076, "mean": 0.164014848011524, "std": 0.2357523358731849, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1230]}}, "Ikba variant leads to eda id": {"direction": "up", "overlap": {"value": 0, "mean": 1.0119760479041915, "std": 0.9122455281435552, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.9251497005988023, "std": 0.8943079191399557, "bin": {"bin_50": 7, "bin_100": 7, "bin_250": 7, "bin_500": 7}}, "score": {"value": 2.3474257476733613, "mean": -0.034370125046371, "std": 1.487549407163387, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0189036405626827, "mean": 0.4134161329669835, "std": 0.3339549062421026, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1225]}}, "Signaling by retinoic acid": {"direction": "dw", "overlap": {"value": 5, "mean": 4.072815533980583, "std": 2.3841179262697216, "bin": {}}, "setsize": {"value": 10, "mean": 11.016990291262136, "std": 1.7452300234803426, "bin": {}}, "score": {"value": -2.345977927783298, "mean": -0.2882740817181056, "std": 0.9570522508702892, "bin": {}}, "pval": {"value": 0.0189772312482767, "mean": 0.5264212530274255, "std": 0.3131242928465726, "bin": {}}, "signature_idxs": {"edge": [2656, 3201, 2578, 2606, 3078], "full": [3078, 2578, 1729, 1880, 3201, 2656, 1279, 1847, 2606, 1771]}}, "Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins": {"direction": "dw", "overlap": {"value": 29, "mean": 20.8373786407767, "std": 8.974357262450994, "bin": {}}, "setsize": {"value": 54, "mean": 62.38106796116505, "std": 5.887120286458052, "bin": {}}, "score": {"value": -2.339629542601775, "mean": 0.8350130317954786, "std": 1.9056004199022172, "bin": {}}, "pval": {"value": 0.0193028760661324, "mean": 0.3584533980641267, "std": 0.3784220720284639, "bin": {}}, "signature_idxs": {"edge": [2927, 2602, 2795, 2037, 2883, 2190, 2569, 2196, 2699, 2587, 2198, 2772, 2332, 2205, 1963, 2164, 2183, 3146, 1949, 2169, 3058, 2893, 2122, 2898, 2538, 2114, 2084, 2126, 2525], "full": [2927, 1028, 1476, 1167, 2569, 1477, 2114, 1170, 1555, 1096, 2795, 2190, 1949, 2037, 2893, 1235, 3146, 1728, 2332, 2898, 1882, 2122, 1486, 1562, 1488, 1337, 2196, 2699, 2198, 1886, 972, 1963, 2126, 2525, 1411, 735, 976, 1344, 2205, 2587, 2538, 758, 1682, 1514, 2602, 2772, 2084, 2164, 2169, 1383, 2883, 440, 2183, 3058]}}, "Activated ntrk2 signals through pi3k": {"direction": "up", "overlap": {"value": 0, "mean": 0.2014563106796116, "std": 0.4010881020012578, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 2.325920461664343, "mean": 1.0248941359596035, "std": 1.5157915361494838, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0200227942405732, "mean": 0.2458096848240638, "std": 0.2648669890573265, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1266]}}, "Interleukin receptor shc signaling": {"direction": "up", "overlap": {"value": 0, "mean": 0.5558252427184466, "std": 0.6567720774309016, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.6553398058252426, "std": 0.7806181463156259, "bin": {"bin_50": 14, "bin_100": 14, "bin_250": 14, "bin_500": 14}}, "score": {"value": 2.325920461664343, "mean": 0.6706475064944829, "std": 1.408494994471721, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0200227942405732, "mean": 0.3789084845876241, "std": 0.3239467923462047, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1266]}}, "Pi3k events in erbb2 signaling": {"direction": "up", "overlap": {"value": 0, "mean": 0.2354368932038835, "std": 0.4411002939451561, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.0728155339805825, "std": 0.2598334697295657, "bin": {"bin_50": 7, "bin_100": 7, "bin_250": 7, "bin_500": 7}}, "score": {"value": 2.325920461664343, "mean": 0.9857971141244752, "std": 1.4826600611123562, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0200227942405732, "mean": 0.2744629376730266, "std": 0.283329174404153, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1266]}}, "Receptor type tyrosine protein phosphatases": {"direction": "dw", "overlap": {"value": 1, "mean": 0.6411042944785276, "std": 0.648285143404869, "bin": {}}, "setsize": {"value": 1, "mean": 1.5153374233128831, "std": 0.5686689681598266, "bin": {}}, "score": {"value": -2.325680373543644, "mean": 0.3042352868991591, "std": 1.6737579336320874, "bin": {}}, "pval": {"value": 0.0200356082734924, "mean": 0.3493660439768286, "std": 0.3220322061569732, "bin": {}}, "signature_idxs": {"edge": [1878], "full": [1878]}}, "Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps": {"direction": "dw", "overlap": {"value": 7, "mean": 6.014563106796117, "std": 2.8591161566949044, "bin": {}}, "setsize": {"value": 11, "mean": 17.274271844660195, "std": 2.4465188670593117, "bin": {}}, "score": {"value": -2.324339471564456, "mean": 0.870961683103299, "std": 1.2657234914365352, "bin": {}}, "pval": {"value": 0.0201073068714214, "mean": 0.329566970411291, "std": 0.3108311955329007, "bin": {}}, "signature_idxs": {"edge": [2993, 2470, 3113, 2614, 2751, 3067, 3167], "full": [2993, 2751, 2470, 2193, 1897, 3167, 3067, 3113, 1985, 2228, 2614]}}, "Rhobtb1 gtpase cycle": {"direction": "dw", "overlap": {"value": 6, "mean": 5.861650485436893, "std": 2.859626086321029, "bin": {}}, "setsize": {"value": 21, "mean": 19.43446601941747, "std": 1.113934885196155, "bin": {}}, "score": {"value": -2.3238109152868365, "mean": 0.163982964274048, "std": 0.8011021456972237, "bin": {}}, "pval": {"value": 0.0201356304672311, "mean": 0.628568970983439, "std": 0.3110709843635175, "bin": {}}, "signature_idxs": {"edge": [2917, 2910, 3212, 3094, 3193, 3124], "full": [1027, 2257, 3124, 2690, 3193, 745, 3094, 530, 906, 1827, 1191, 3212, 991, 1199, 2910, 1068, 1606, 2917, 775, 551, 2025]}}, "Recruitment of numa to mitotic centrosomes": {"direction": "up", "overlap": {"value": 12, "mean": 11.883495145631068, "std": 5.3811987888681685, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 3, "bin_500": 6}}, "setsize": {"value": 32, "mean": 35.75485436893204, "std": 4.283134766195611, "bin": {"bin_50": 90, "bin_100": 90, "bin_250": 90, "bin_500": 90}}, "score": {"value": 2.3152838224819217, "mean": 0.624756920034884, "std": 1.0244661495687433, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 1.3878958479943702, "bin_500": 1.395760743321719}}, "pval": {"value": 0.020597404507946, "mean": 0.5097170288431273, "std": 0.3603491445972374, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.3751740895203853, "bin_500": 0.2762651675790059}}, "signature_idxs": {"edge": [143, 702, 511, 608, 621, 665, 302, 401, 127, 402, 538, 236], "full": [127, 1097, 401, 511, 402, 1237, 1403, 665, 730, 1342, 1818, 1121, 1122, 1579, 2135, 302, 2589, 608, 236, 1748, 1431, 1676, 3029, 1833, 538, 1515, 621, 931, 2297, 143, 702, 1465]}}, "Nrcam interactions": {"direction": "up", "overlap": {"value": 0, "mean": 0.7265625, "std": 0.6889928158264182, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 2, "mean": 1.6536458333333333, "std": 0.7124906721489801, "bin": {"bin_50": 7, "bin_100": 7, "bin_250": 7, "bin_500": 7}}, "score": {"value": 2.306812434773074, "mean": 0.0284285526839588, "std": 1.4501015572803737, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 6.708502024291498, "bin_500": 3.250167672702884}}, "pval": {"value": 0.0210652787346381, "mean": 0.4420255768724557, "std": 0.3500992635501144, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1583736196074974, "bin_500": 0.295760276625992}}, "signature_idxs": {"edge": [], "full": [1355, 188]}}, "Ionotropic activity of kainate receptors": {"direction": "up", "overlap": {"value": 0, "mean": 0.7265625, "std": 0.6889928158264182, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 2, "mean": 1.6536458333333333, "std": 0.7124906721489801, "bin": {"bin_50": 3, "bin_100": 3, "bin_250": 3, "bin_500": 3}}, "score": {"value": 2.306812434773074, "mean": 0.0284285526839588, "std": 1.4501015572803737, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 20.1336032388664, "bin_500": 9.754527162977867}}, "pval": {"value": 0.0210652787346381, "mean": 0.4420255768724557, "std": 0.3500992635501144, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0712161326093482, "bin_500": 0.1395007501750084}}, "signature_idxs": {"edge": [], "full": [1355, 188]}}, "Stat5 activation": {"direction": "up", "overlap": {"value": 0, "mean": 0.7645631067961165, "std": 0.6077225936822666, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 2, "mean": 1.953883495145631, "std": 0.2792317234102489, "bin": {"bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 2.3017276529563224, "mean": 0.0920223272459151, "std": 1.139410126933314, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 13.421052631578949, "bin_500": 6.502347417840376}}, "pval": {"value": 0.0213505357188341, "mean": 0.5867331333762598, "std": 0.3453959203236477, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0938138368307335, "bin_500": 0.1815422125939431}}, "signature_idxs": {"edge": [], "full": [1266, 116]}}, "Pi 3k cascade fgfr3": {"direction": "up", "overlap": {"value": 0, "mean": 0.7548543689320388, "std": 0.6038715932395639, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 2, "mean": 1.9368932038834952, "std": 0.2431549473081202, "bin": {"bin_50": 8, "bin_100": 8, "bin_250": 8, "bin_500": 8}}, "score": {"value": 2.3017276529563224, "mean": 0.0871952603345622, "std": 1.138928574229828, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 5.749566223250434, "bin_500": 2.785570566254671}}, "pval": {"value": 0.0213505357188341, "mean": 0.5877000432803414, "std": 0.3451651831028046, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1788587842302525, "bin_500": 0.3301808657155594}}, "signature_idxs": {"edge": [], "full": [1266, 116]}}, "Pi 3k cascade fgfr2": {"direction": "up", "overlap": {"value": 0, "mean": 0.7548543689320388, "std": 0.6038715932395639, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 2, "mean": 1.9368932038834952, "std": 0.2431549473081202, "bin": {"bin_50": 8, "bin_100": 8, "bin_250": 8, "bin_500": 8}}, "score": {"value": 2.3017276529563224, "mean": 0.0871952603345622, "std": 1.138928574229828, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 5.749566223250434, "bin_500": 2.785570566254671}}, "pval": {"value": 0.0213505357188341, "mean": 0.5877000432803414, "std": 0.3451651831028046, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1788587842302525, "bin_500": 0.3301808657155594}}, "signature_idxs": {"edge": [], "full": [1266, 116]}}, "Pi 3k cascade fgfr4": {"direction": "up", "overlap": {"value": 0, "mean": 0.7548543689320388, "std": 0.6038715932395639, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 2, "mean": 1.9368932038834952, "std": 0.2431549473081202, "bin": {"bin_50": 8, "bin_100": 8, "bin_250": 8, "bin_500": 8}}, "score": {"value": 2.3017276529563224, "mean": 0.0871952603345622, "std": 1.138928574229828, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 5.749566223250434, "bin_500": 2.785570566254671}}, "pval": {"value": 0.0213505357188341, "mean": 0.5877000432803414, "std": 0.3451651831028046, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1788587842302525, "bin_500": 0.3301808657155594}}, "signature_idxs": {"edge": [], "full": [1266, 116]}}, "Stat5 activation downstream of flt3 itd mutants": {"direction": "up", "overlap": {"value": 0, "mean": 0.7645631067961165, "std": 0.6077225936822666, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 2, "mean": 1.953883495145631, "std": 0.2792317234102489, "bin": {"bin_50": 6, "bin_100": 6, "bin_250": 6, "bin_500": 6}}, "score": {"value": 2.3017276529563224, "mean": 0.0920223272459151, "std": 1.139410126933314, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 8.051012145748988, "bin_500": 3.900603621730382}}, "pval": {"value": 0.0213505357188341, "mean": 0.5867331333762598, "std": 0.3453959203236477, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1373795195898598, "bin_500": 0.2595746201812825}}, "signature_idxs": {"edge": [], "full": [1266, 116]}}, "Pi 3k cascade fgfr1": {"direction": "up", "overlap": {"value": 0, "mean": 0.7548543689320388, "std": 0.6038715932395639, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 2, "mean": 1.9368932038834952, "std": 0.2431549473081202, "bin": {"bin_50": 8, "bin_100": 8, "bin_250": 8, "bin_500": 8}}, "score": {"value": 2.3017276529563224, "mean": 0.0871952603345622, "std": 1.138928574229828, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 5.749566223250434, "bin_500": 2.785570566254671}}, "pval": {"value": 0.0213505357188341, "mean": 0.5877000432803414, "std": 0.3451651831028046, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1788587842302525, "bin_500": 0.3301808657155594}}, "signature_idxs": {"edge": [], "full": [1266, 116]}}, "Telomere c strand lagging strand synthesis": {"direction": "up", "overlap": {"value": 8, "mean": 7.553398058252427, "std": 4.0911416388962625, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 4, "bin_500": 9}}, "setsize": {"value": 23, "mean": 20.949029126213592, "std": 2.547571474292212, "bin": {"bin_50": 37, "bin_100": 37, "bin_250": 37, "bin_500": 37}}, "score": {"value": 2.2994164941026733, "mean": -0.3937170527830363, "std": 0.9683039910705572, "bin": {"bin_50": 5.851273148148148, "bin_100": 2.8517573696145124, "bin_250": 4.92548435171386, "bin_500": 6.356266432953549}}, "pval": {"value": 0.0214813002215128, "mean": 0.5187983424775273, "std": 0.3304692703079571, "bin": {"bin_50": 0.1635258499471353, "bin_100": 0.3034780999558708, "bin_250": 0.0120207550158922, "bin_500": 5.3690164151697385e-05}}, "signature_idxs": {"edge": [252, 130, 131, 329, 21, 260, 292, 162], "full": [1482, 252, 1242, 1104, 591, 729, 21, 329, 369, 2043, 130, 292, 1496, 805, 737, 131, 2581, 260, 990, 3190, 162, 1467, 2790]}}, "Maturation of sars cov 1 nucleoprotein": {"direction": "up", "overlap": {"value": 0, "mean": 0.819718309859155, "std": 0.7010293675530229, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.6225352112676057, "std": 0.5551797534306537, "bin": {"bin_50": 9, "bin_100": 9, "bin_250": 9, "bin_500": 9}}, "score": {"value": 2.298480684241709, "mean": 0.130441766743843, "std": 1.4272108137621713, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0215344460072541, "mean": 0.4454232783656918, "std": 0.3386072412679707, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1259]}}, "Recycling of eif2 gdp": {"direction": "up", "overlap": {"value": 5, "mean": 3.313106796116505, "std": 2.004006438145489, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 3}}, "setsize": {"value": 8, "mean": 6.905339805825243, "std": 0.6955270621915002, "bin": {"bin_50": 8, "bin_100": 8, "bin_250": 8, "bin_500": 8}}, "score": {"value": 2.296690596211984, "mean": 0.1197760753571412, "std": 0.8511996602760747, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 5.749566223250434, "bin_500": 11.74909090909091}}, "pval": {"value": 0.021636426281804, "mean": 0.5850286119533992, "std": 0.3097836852205068, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1788587842302525, "bin_500": 0.0053942671417733}}, "signature_idxs": {"edge": [581, 154, 349, 525, 418], "full": [581, 1561, 670, 525, 154, 418, 349, 1864]}}, "Pecam1 interactions": {"direction": "up", "overlap": {"value": 2, "mean": 1.565432098765432, "std": 1.020186438277932, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 3, "bin_500": 3}}, "setsize": {"value": 5, "mean": 3.145679012345679, "std": 1.150850397622413, "bin": {"bin_50": 9, "bin_100": 9, "bin_250": 9, "bin_500": 9}}, "score": {"value": 2.2927839318881182, "mean": -0.3567325573133383, "std": 1.0721678654460265, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 20.289795918367343, "bin_500": 9.78989898989899}}, "pval": {"value": 0.0218604475465657, "mean": 0.5127589476355852, "std": 0.3172357645971152, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0010713621736615, "bin_500": 0.0078003581692789}}, "signature_idxs": {"edge": [116, 201], "full": [1238, 219, 201, 1485, 116]}}, "Cyclin d associated events in g1": {"direction": "up", "overlap": {"value": 9, "mean": 4.366504854368932, "std": 2.5273541207987025, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 3, "bin_500": 4}}, "setsize": {"value": 13, "mean": 10.116504854368932, "std": 1.6637247419470345, "bin": {"bin_50": 45, "bin_100": 45, "bin_250": 45, "bin_500": 45}}, "score": {"value": 2.2883966763331087, "mean": 0.1222182547646903, "std": 0.9055693104495058, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 2.888046647230321, "bin_500": 1.907178828873309}}, "pval": {"value": 0.0221144310289471, "mean": 0.5717022199186504, "std": 0.3101665598109623, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0958173315210673, "bin_500": 0.1758221500942633}}, "signature_idxs": {"edge": [802, 665, 381, 181, 528, 219, 201, 1057, 589], "full": [1955, 219, 1241, 201, 589, 665, 1566, 802, 528, 181, 1051, 381, 1057]}}, "Pkmts methylate histone lysines": {"direction": "dw", "overlap": {"value": 8, "mean": 4.837378640776699, "std": 3.2042539871103717, "bin": {}}, "setsize": {"value": 13, "mean": 14.12864077669903, "std": 3.75660649087302, "bin": {}}, "score": {"value": -2.2844971195969443, "mean": -0.3790466366518857, "std": 1.1177819871791863, "bin": {}}, "pval": {"value": 0.0223423316783586, "mean": 0.4287134426211142, "std": 0.2979041388027998, "bin": {}}, "signature_idxs": {"edge": [2529, 2637, 2309, 3214, 2483, 2948, 2359, 3004], "full": [1630, 3214, 2637, 2529, 1351, 821, 2359, 2483, 1904, 3004, 1840, 2948, 2309]}}, "Reproduction": {"direction": "dw", "overlap": {"value": 13, "mean": 8.531553398058252, "std": 4.034616536507926, "bin": {}}, "setsize": {"value": 26, "mean": 24.47087378640777, "std": 2.9265484182333807, "bin": {}}, "score": {"value": -2.2841536880852567, "mean": -0.5005338402003618, "std": 0.7833432275346869, "bin": {}}, "pval": {"value": 0.0223625002412741, "mean": 0.5625558367775192, "std": 0.313466390403865, "bin": {}}, "signature_idxs": {"edge": [2581, 2960, 2562, 2912, 3012, 3213, 2707, 2649, 3190, 3131, 2674, 2459, 3063], "full": [1946, 2459, 2329, 2960, 1241, 1242, 3213, 589, 591, 21, 3063, 2649, 2581, 979, 1351, 2707, 3190, 2912, 3131, 3012, 2373, 2674, 273, 1467, 2100, 2562]}}, "Meiosis": {"direction": "dw", "overlap": {"value": 13, "mean": 8.531553398058252, "std": 4.052624046790471, "bin": {}}, "setsize": {"value": 26, "mean": 24.313106796116504, "std": 2.9023798501264153, "bin": {}}, "score": {"value": -2.2841536880852567, "mean": -0.5122085329727866, "std": 0.7894362578314096, "bin": {}}, "pval": {"value": 0.0223625002412741, "mean": 0.5590882737524774, "std": 0.3162215463806687, "bin": {}}, "signature_idxs": {"edge": [2581, 2960, 2562, 2912, 3012, 3213, 2707, 2649, 3190, 3131, 2674, 2459, 3063], "full": [1946, 2459, 2329, 2960, 1241, 1242, 3213, 589, 591, 21, 3063, 2649, 2581, 979, 1351, 2707, 3190, 2912, 3131, 3012, 2373, 2674, 273, 1467, 2100, 2562]}}, "Darpp 32 events": {"direction": "up", "overlap": {"value": 4, "mean": 3.337378640776699, "std": 2.0539474006391516, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 10, "mean": 8.611650485436893, "std": 1.0656417885616585, "bin": {"bin_50": 20, "bin_100": 20, "bin_250": 20, "bin_500": 20}}, "score": {"value": 2.279994257548805, "mean": -0.1363675416686346, "std": 0.772534859100602, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 2.11570424035798, "bin_500": 1.0249920576088107}}, "pval": {"value": 0.0226080290593475, "mean": 0.6078568346690442, "std": 0.2862934874267145, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.3891747515056749, "bin_500": 0.6330296848923271}}, "signature_idxs": {"edge": [730, 531, 665, 220], "full": [220, 1483, 1403, 665, 1566, 730, 1265, 531, 748, 1592]}}, "Activation of ampk downstream of nmdars": {"direction": "up", "overlap": {"value": 3, "mean": 3.354368932038835, "std": 1.771033196282823, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 2, "bin_500": 4}}, "setsize": {"value": 7, "mean": 6.451456310679611, "std": 1.4598419968812493, "bin": {"bin_50": 21, "bin_100": 21, "bin_250": 21, "bin_500": 21}}, "score": {"value": 2.2772124071324917, "mean": 0.5566970459139938, "std": 1.088746190595968, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 4.248609328198545, "bin_500": 4.611097880447725}}, "pval": {"value": 0.0227735445895702, "mean": 0.4440483464816752, "std": 0.3283169353723064, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0914454637274335, "bin_500": 0.0173495207202435}}, "signature_idxs": {"edge": [143, 302, 236], "full": [401, 1500, 1966, 302, 1429, 236, 143]}}, "Mitochondrial trna aminoacylation": {"direction": "dw", "overlap": {"value": 9, "mean": 7.165048543689321, "std": 3.6592669629833474, "bin": {}}, "setsize": {"value": 19, "mean": 16.62378640776699, "std": 1.831948729782882, "bin": {}}, "score": {"value": -2.276336545096793, "mean": -0.6180611316575642, "std": 0.7621486806873613, "bin": {}}, "pval": {"value": 0.0228258744084142, "mean": 0.5231440727245715, "std": 0.3181724160645508, "bin": {}}, "signature_idxs": {"edge": [2465, 2998, 2507, 2828, 3080, 3007, 3181, 2536, 2445], "full": [2465, 969, 598, 1410, 2998, 2536, 1594, 3007, 2224, 3080, 1362, 3181, 1924, 2828, 2010, 1460, 2445, 2507, 1223]}}, "Serine biosynthesis": {"direction": "up", "overlap": {"value": 1, "mean": 1.2718446601941749, "std": 0.7199538113189287, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 2, "mean": 2.366504854368932, "std": 0.5478505372284339, "bin": {"bin_50": 7, "bin_100": 7, "bin_250": 7, "bin_500": 7}}, "score": {"value": 2.276323210068953, "mean": -0.530710826054965, "std": 1.085348282983829, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 6.708502024291498, "bin_500": 3.250167672702884}}, "pval": {"value": 0.0228266719383061, "mean": 0.5087576029149842, "std": 0.3240824847404142, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1583736196074974, "bin_500": 0.295760276625992}}, "signature_idxs": {"edge": [216], "full": [506, 216]}}, "Translesion synthesis by y family dna polymerases bypasses lesions on dna template": {"direction": "up", "overlap": {"value": 11, "mean": 7.359223300970874, "std": 4.38909586401741, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 5}}, "setsize": {"value": 22, "mean": 20.859223300970875, "std": 2.011999772877474, "bin": {"bin_50": 41, "bin_100": 41, "bin_250": 41, "bin_500": 41}}, "score": {"value": 2.264443895943514, "mean": -0.2672141946628648, "std": 0.8912159134669635, "bin": {"bin_50": 5.2640625, "bin_100": 2.565561224489796, "bin_250": 1.002834008097166, "bin_500": 2.721996844714897}}, "pval": {"value": 0.0235468267425738, "mean": 0.5561702710937696, "std": 0.3145503701499852, "bin": {"bin_50": 0.1795501084992132, "bin_100": 0.3302382631712943, "bin_250": 0.6363606533565179, "bin_500": 0.0480087672890962}}, "signature_idxs": {"edge": [607, 369, 252, 729, 329, 21, 676, 292, 591, 828, 805], "full": [252, 1242, 591, 729, 21, 329, 369, 2043, 292, 1496, 805, 676, 2419, 607, 827, 828, 990, 1367, 1761, 2015, 2305, 2790]}}, "Formation of apoptosome": {"direction": "up", "overlap": {"value": 1, "mean": 1.0097087378640777, "std": 1.0634724733504557, "bin": {"bin_50": 0, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 2, "mean": 3.228155339805826, "std": 0.9354836219504358, "bin": {"bin_50": 11, "bin_100": 11, "bin_250": 11, "bin_500": 11}}, "score": {"value": 2.263870072133178, "mean": 0.2480528982202133, "std": 1.0523011680504897, "bin": {"bin_50": 0.0, "bin_100": 10.292857142857144, "bin_250": 4.023481781376519, "bin_500": 1.9492957746478876}}, "pval": {"value": 0.0235821071464337, "mean": 0.5379221970101167, "std": 0.3235131485152152, "bin": {"bin_50": 1.0, "bin_100": 0.1018169846714528, "bin_250": 0.2373820829012167, "bin_500": 0.4236908718837023}}, "signature_idxs": {"edge": [78], "full": [78, 516]}}, "Signaling by mapk mutants": {"direction": "up", "overlap": {"value": 1, "mean": 0.7475728155339806, "std": 0.649397728473423, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 2, "mean": 1.849514563106796, "std": 0.357546598608161, "bin": {"bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 2.263870072133142, "mean": 0.1918867044816394, "std": 1.1557340681989243, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0235821071464359, "mean": 0.5683429266505162, "std": 0.345439881836336, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [549], "full": [516, 549]}}, "Intracellular signaling by second messengers": {"direction": "up", "overlap": {"value": 43, "mean": 23.20145631067961, "std": 10.291654542344736, "bin": {"bin_50": 2, "bin_100": 4, "bin_250": 13, "bin_500": 21}}, "setsize": {"value": 94, "mean": 86.0631067961165, "std": 8.129468035609259, "bin": {"bin_50": 233, "bin_100": 233, "bin_250": 233, "bin_500": 233}}, "score": {"value": 2.26281961644512, "mean": 0.1421070399989671, "std": 0.948765500839012, "bin": {"bin_50": 1.8266556138896564, "bin_100": 1.8143874971270968, "bin_250": 2.446112185686654, "bin_500": 1.969918120327519}}, "pval": {"value": 0.0236468111599605, "mean": 0.655790329270176, "std": 0.3384114915870303, "bin": {"bin_50": 0.3087764969161045, "bin_100": 0.1905585809376989, "bin_250": 0.0045469009093886, "bin_500": 0.0049510785025372}}, "signature_idxs": {"edge": [730, 370, 373, 912, 12, 738, 258, 713, 26, 508, 151, 514, 515, 516, 651, 909, 904, 863, 527, 526, 407, 62, 855, 179, 297, 797, 298, 71, 665, 201, 821, 580, 814, 458, 568, 364, 220, 224, 225, 227, 115, 116, 590], "full": [1088, 568, 26, 1024, 1629, 1225, 958, 1870, 959, 2325, 508, 3214, 651, 1723, 580, 3022, 220, 201, 1483, 2694, 1403, 797, 1485, 364, 1040, 3166, 590, 115, 407, 224, 514, 515, 458, 225, 516, 665, 1566, 730, 370, 2342, 373, 1258, 227, 738, 2808, 1259, 526, 1345, 297, 527, 151, 814, 298, 179, 1266, 904, 1421, 1972, 1974, 116, 258, 821, 907, 2273, 909, 1430, 1275, 1592, 2219, 2358, 912, 2359, 3004, 1062, 2710, 2712, 2434, 3105, 1522, 2075, 71, 1695, 1448, 12, 855, 1209, 3116, 1381, 2980, 2249, 62, 863, 713, 2955]}}, "Dna damage bypass": {"direction": "up", "overlap": {"value": 13, "mean": 8.635922330097088, "std": 4.999851538940243, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 6}}, "setsize": {"value": 30, "mean": 24.038834951456312, "std": 2.65371082956183, "bin": {"bin_50": 49, "bin_100": 49, "bin_250": 49, "bin_500": 49}}, "score": {"value": 2.257495982309627, "mean": -0.3198527593153901, "std": 0.9067730781616636, "bin": {"bin_50": 4.383246527777778, "bin_100": 2.136267006802721, "bin_250": 0.8350202429149798, "bin_500": 2.738230289279637}}, "pval": {"value": 0.0239771002551605, "mean": 0.5506696989091423, "std": 0.3196109252473654, "bin": {"bin_50": 0.2107016729382093, "bin_100": 0.3807425591652282, "bin_250": 0.7016412630610651, "bin_500": 0.0310662112019685}}, "signature_idxs": {"edge": [451, 603, 607, 369, 252, 729, 329, 21, 676, 292, 591, 828, 805], "full": [451, 252, 1242, 591, 729, 21, 329, 369, 2043, 292, 1496, 805, 676, 2419, 603, 607, 2061, 2480, 827, 828, 990, 1197, 1848, 1367, 1761, 2015, 2305, 1536, 1780, 2790]}}, "Innate immune system": {"direction": "up", "overlap": {"value": 116, "mean": 58.13106796116505, "std": 23.17655548398375, "bin": {"bin_50": 6, "bin_100": 11, "bin_250": 29, "bin_500": 56}}, "setsize": {"value": 287, "mean": 283.2621359223301, "std": 21.516966060472942, "bin": {"bin_50": 624, "bin_100": 624, "bin_250": 624, "bin_500": 624}}, "score": {"value": 2.2570840125030305, "mean": 0.0553962685980947, "std": 1.144037613250001, "bin": {"bin_50": 2.1515014675999096, "bin_100": 1.933931484502447, "bin_250": 2.081554813706304, "bin_500": 2.036517749028105}}, "pval": {"value": 0.0240028256767994, "mean": 0.7001179978548713, "std": 0.3669222261646001, "bin": {"bin_50": 0.076909770458014, "bin_100": 0.0390763228088234, "bin_250": 0.0005745343964587, "bin_500": 5.939945188067145e-06}}, "signature_idxs": {"edge": [8, 564, 26, 520, 28, 535, 514, 515, 34, 516, 33, 46, 530, 534, 527, 526, 62, 76, 71, 67, 626, 78, 575, 103, 568, 599, 115, 114, 595, 116, 590, 141, 592, 136, 705, 167, 166, 713, 678, 151, 677, 651, 657, 181, 676, 179, 661, 665, 195, 201, 770, 784, 232, 219, 224, 225, 727, 227, 725, 717, 748, 253, 738, 251, 256, 258, 304, 851, 852, 302, 864, 283, 862, 861, 855, 296, 297, 797, 298, 343, 790, 827, 326, 328, 814, 812, 376, 912, 360, 363, 942, 371, 370, 373, 433, 883, 880, 878, 398, 904, 403, 907, 407, 402, 896, 417, 998, 995, 1004, 1014, 967, 966, 959, 958, 458, 473], "full": [2745, 283, 1088, 568, 26, 2514, 3121, 1024, 1792, 195, 78, 1093, 1629, 1225, 1226, 1166, 1717, 790, 3198, 2887, 958, 2111, 959, 1030, 2460, 1638, 398, 651, 575, 1724, 1331, 2635, 1172, 2331, 717, 1726, 114, 33, 1877, 2191, 1033, 1236, 2933, 1956, 402, 1557, 2466, 326, 2119, 1237, 1238, 219, 3153, 878, 1035, 251, 2411, 966, 360, 1239, 2468, 2259, 1879, 657, 880, 1805, 1806, 253, 201, 1645, 883, 725, 328, 403, 2751, 967, 2470, 1808, 3092, 2335, 1883, 1646, 34, 1403, 661, 3203, 797, 1959, 363, 1485, 2641, 1648, 1040, 727, 1563, 1961, 2414, 1041, 590, 115, 407, 224, 514, 515, 458, 225, 516, 592, 665, 1566, 2753, 1651, 2524, 595, 1567, 1568, 370, 371, 520, 1180, 1256, 2127, 28, 1889, 373, 1257, 8, 1258, 227, 738, 2649, 599, 1415, 376, 1260, 1261, 256, 526, 296, 1117, 896, 1574, 1047, 297, 676, 677, 527, 1661, 1120, 2134, 678, 2051, 103, 1502, 1577, 812, 1742, 151, 1503, 1969, 2206, 814, 298, 179, 2268, 2904, 1266, 904, 2135, 232, 181, 1421, 302, 473, 530, 1893, 3211, 1972, 2656, 1190, 304, 1896, 1974, 116, 258, 1897, 748, 3049, 2354, 2214, 1900, 1747, 2760, 986, 907, 3167, 1131, 1827, 2763, 534, 535, 1057, 417, 2531, 1589, 1979, 1676, 827, 1592, 1058, 2358, 912, 2812, 67, 2278, 1196, 3129, 2488, 2281, 1988, 2362, 2710, 136, 2365, 1843, 2367, 1286, 3205, 1911, 995, 2945, 2290, 1916, 2370, 343, 2291, 71, 1371, 998, 2975, 1449, 1762, 851, 770, 852, 2876, 855, 141, 1209, 1376, 1378, 1004, 2084, 626, 1930, 2612, 2614, 2949, 433, 1211, 1931, 1535, 705, 1618, 942, 1310, 2308, 1014, 1937, 46, 1314, 861, 862, 166, 2247, 62, 713, 1158, 864, 784, 2563, 2955, 564, 76, 2845, 1322, 167]}}, "Interleukin 21 signaling": {"direction": "up", "overlap": {"value": 1, "mean": 1.1674757281553398, "std": 0.7163895702766538, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 2, "mean": 2.021844660194174, "std": 0.3904298044210051, "bin": {"bin_50": 5, "bin_100": 5, "bin_250": 5, "bin_500": 5}}, "score": {"value": 2.2569448178250835, "mean": -0.2431718569830326, "std": 1.0832950571167843, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 4.8762575452716295}}, "pval": {"value": 0.0240115230854893, "mean": 0.5731789221030253, "std": 0.329721028343633, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.2215335762210877}}, "signature_idxs": {"edge": [409], "full": [409, 521]}}, "Interleukin 9 signaling": {"direction": "up", "overlap": {"value": 1, "mean": 1.1674757281553398, "std": 0.7163895702766538, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 2, "mean": 2.021844660194174, "std": 0.3904298044210051, "bin": {"bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 2.2569448178250835, "mean": -0.2431718569830326, "std": 1.0832950571167843, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 6.502347417840376}}, "pval": {"value": 0.0240115230854893, "mean": 0.5731789221030253, "std": 0.329721028343633, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.1815422125939431}}, "signature_idxs": {"edge": [409], "full": [409, 521]}}, "Trna processing in the nucleus": {"direction": "dw", "overlap": {"value": 20, "mean": 12.1747572815534, "std": 6.015638494331737, "bin": {}}, "setsize": {"value": 42, "mean": 40.25970873786408, "std": 2.503982829864004, "bin": {}}, "score": {"value": -2.2532712173271454, "mean": -0.397566647401479, "std": 0.572004597726313, "bin": {}}, "pval": {"value": 0.0242420534026091, "mean": 0.6876943186001854, "std": 0.2755891489334771, "bin": {}}, "signature_idxs": {"edge": [2528, 2527, 2797, 2805, 2688, 2969, 3009, 2702, 2779, 2771, 2773, 2856, 2781, 2782, 2915, 2676, 2657, 2755, 2639, 3189], "full": [1795, 2688, 792, 290, 2797, 2639, 2856, 2805, 669, 2755, 2702, 2527, 202, 2528, 983, 1126, 203, 2136, 2657, 3189, 540, 2969, 3009, 2771, 1759, 2231, 2437, 2073, 2773, 1760, 2915, 2079, 2779, 1928, 1299, 2781, 2782, 2676, 2306, 2312, 319, 502]}}, "Pre notch processing in the endoplasmic reticulum": {"direction": "up", "overlap": {"value": 0, "mean": 0.7465940054495913, "std": 0.7408538459098984, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.5313351498637602, "std": 0.6118485987873605, "bin": {"bin_50": 5, "bin_100": 5, "bin_250": 5, "bin_500": 5}}, "score": {"value": 2.253233039316016, "mean": 0.1821082105438322, "std": 1.368628083136707, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0242444592346235, "mean": 0.4622110242649548, "std": 0.3375801102666664, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1380]}}, "Regulation of pten mrna translation": {"direction": "up", "overlap": {"value": 0, "mean": 0.2645631067961165, "std": 0.4573101530849929, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.1262135922330097, "std": 0.3320899296405257, "bin": {"bin_50": 9, "bin_100": 9, "bin_250": 9, "bin_500": 9}}, "score": {"value": 2.251261031666313, "mean": 0.9720520862996224, "std": 1.5038280568948086, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0243690093747952, "mean": 0.2773987342797716, "std": 0.2855906741345675, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1381]}}, "Competing endogenous rnas cernas regulate pten translation": {"direction": "up", "overlap": {"value": 0, "mean": 0.2645631067961165, "std": 0.4573101530849929, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.1262135922330097, "std": 0.3320899296405257, "bin": {"bin_50": 8, "bin_100": 8, "bin_250": 8, "bin_500": 8}}, "score": {"value": 2.251261031666313, "mean": 0.9720520862996224, "std": 1.5038280568948086, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0243690093747952, "mean": 0.2773987342797716, "std": 0.2855906741345675, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1381]}}, "Pcna dependent long patch base excision repair": {"direction": "up", "overlap": {"value": 10, "mean": 6.305825242718447, "std": 3.5188349032394246, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 3, "bin_500": 7}}, "setsize": {"value": 20, "mean": 18.131067961165048, "std": 1.8997459782268384, "bin": {"bin_50": 24, "bin_100": 24, "bin_250": 24, "bin_500": 24}}, "score": {"value": 2.249929161143068, "mean": -0.2629874999917882, "std": 0.968142963238218, "bin": {"bin_50": 9.170289855072465, "bin_100": 4.469387755102041, "bin_250": 5.788338192419825, "bin_500": 8.11872529052354}}, "pval": {"value": 0.0244534424697824, "mean": 0.517441963572211, "std": 0.3133577308525272, "bin": {"bin_50": 0.1093006244161378, "bin_100": 0.208984012191681, "bin_250": 0.0197332243190265, "bin_500": 0.0001063915357976}}, "signature_idxs": {"edge": [607, 369, 252, 130, 329, 729, 21, 173, 292, 591], "full": [252, 1242, 1104, 591, 173, 729, 21, 329, 369, 2043, 130, 292, 1496, 805, 2419, 607, 990, 2015, 2305, 2790]}}, "Aurka activation by tpx2": {"direction": "up", "overlap": {"value": 10, "mean": 10.276699029126211, "std": 4.914920890107843, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 4}}, "setsize": {"value": 29, "mean": 31.893203883495147, "std": 4.281168113347361, "bin": {"bin_50": 73, "bin_100": 73, "bin_250": 73, "bin_500": 73}}, "score": {"value": 2.24109061175304, "mean": 0.5790832053921023, "std": 0.9784215516709706, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.5553306342780027, "bin_500": 1.1299653816816289}}, "pval": {"value": 0.0250202062060134, "mean": 0.5039527741558584, "std": 0.3534896123548716, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.835361924407007, "bin_500": 0.4808642038976582}}, "signature_idxs": {"edge": [511, 702, 608, 621, 665, 302, 401, 127, 402, 538], "full": [1165, 127, 1097, 401, 511, 402, 1237, 1403, 665, 730, 1342, 1818, 1121, 1122, 1579, 2135, 302, 2589, 608, 1748, 1431, 1676, 1833, 538, 1515, 621, 702, 1465, 2448]}}, "Pentose phosphate pathway": {"direction": "up", "overlap": {"value": 8, "mean": 4.313106796116505, "std": 1.9450018240070384, "bin": {"bin_50": 0, "bin_100": 1, "bin_250": 1, "bin_500": 4}}, "setsize": {"value": 10, "mean": 7.456310679611651, "std": 1.1301404589148365, "bin": {"bin_50": 13, "bin_100": 13, "bin_250": 13, "bin_500": 13}}, "score": {"value": 2.239015241146065, "mean": -0.8086818382913112, "std": 1.033041632680426, "bin": {"bin_50": 0.0, "bin_100": 8.575680272108844, "bin_250": 3.3522267206477734, "bin_500": 8.717049032838506}}, "pval": {"value": 0.0251549244928928, "mean": 0.3695439371143908, "std": 0.3104960773934243, "bin": {"bin_50": 1.0, "bin_100": 0.1191939669275513, "bin_250": 0.2740704871267072, "bin_500": 0.0028246814840344}}, "signature_idxs": {"edge": [76, 851, 372, 291, 736, 881, 898, 413], "full": [291, 881, 1036, 1649, 372, 736, 413, 898, 851, 76]}}, "Regulation of foxo transcriptional activity by acetylation": {"direction": "dw", "overlap": {"value": 1, "mean": 0.6690909090909091, "std": 0.5874049949559278, "bin": {}}, "setsize": {"value": 1, "mean": 1.1781818181818182, "std": 0.4908956227108714, "bin": {}}, "score": {"value": -2.236901032868401, "mean": -0.3647086919124337, "std": 1.8913107983715771, "bin": {}}, "pval": {"value": 0.0252928090465045, "mean": 0.2693761942237749, "std": 0.2961166084857556, "bin": {}}, "signature_idxs": {"edge": [1923], "full": [1923]}}, "Acyl chain remodelling of pc": {"direction": "dw", "overlap": {"value": 1, "mean": 0.7445255474452555, "std": 0.7548306435500738, "bin": {}}, "setsize": {"value": 1, "mean": 1.8394160583941608, "std": 0.9114057747583176, "bin": {}}, "score": {"value": -2.234918774124583, "mean": 0.5434108593850304, "std": 1.60855215492092, "bin": {}}, "pval": {"value": 0.0254226817811971, "mean": 0.3347143413864514, "std": 0.309993750104757, "bin": {}}, "signature_idxs": {"edge": [1916], "full": [1916]}}, "Intra golgi traffic": {"direction": "up", "overlap": {"value": 3, "mean": 4.424757281553398, "std": 2.688824171738392, "bin": {"bin_50": 0, "bin_100": 2, "bin_250": 4, "bin_500": 4}}, "setsize": {"value": 9, "mean": 13.87135922330097, "std": 3.845367291797066, "bin": {"bin_50": 42, "bin_100": 42, "bin_250": 42, "bin_500": 42}}, "score": {"value": 2.2266853590734303, "mean": 0.7636302424906817, "std": 0.9598354803720488, "bin": {"bin_50": 0.0, "bin_100": 5.184020618556701, "bin_250": 4.275237273511648, "bin_500": 2.058384828467931}}, "pval": {"value": 0.0259683096083112, "mean": 0.4243971711811651, "std": 0.3140361333882177, "bin": {"bin_50": 1.0, "bin_100": 0.0625314301217693, "bin_250": 0.0185450998789275, "bin_500": 0.1473962800256471}}, "signature_idxs": {"edge": [191, 55, 85], "full": [217, 85, 1811, 1187, 55, 1981, 191, 1929, 2741]}}, "Selective autophagy": {"direction": "up", "overlap": {"value": 10, "mean": 7.315533980582524, "std": 3.350474746292583, "bin": {"bin_50": 0, "bin_100": 2, "bin_250": 7, "bin_500": 11}}, "setsize": {"value": 31, "mean": 31.50728155339806, "std": 3.101431769008479, "bin": {"bin_50": 67, "bin_100": 67, "bin_250": 67, "bin_500": 67}}, "score": {"value": 2.2221688857632103, "mean": 0.9304065525388932, "std": 1.074438805028982, "bin": {"bin_50": 0.0, "bin_100": 3.18223632038065, "bin_250": 4.786721991701245, "bin_500": 3.889043707832209}}, "pval": {"value": 0.026271894329465, "mean": 0.4028226131520862, "std": 0.3502038092942861, "bin": {"bin_50": 1.0, "bin_100": 0.1378217675082697, "bin_250": 0.0011609715580815, "bin_500": 0.0003614243000186}}, "signature_idxs": {"edge": [143, 302, 103, 364, 87, 201, 93, 270, 236, 169], "full": [169, 647, 1331, 2403, 2574, 401, 1237, 2690, 657, 201, 364, 2801, 87, 1500, 1966, 676, 103, 2135, 1421, 302, 1131, 2589, 236, 1676, 1914, 270, 2552, 93, 143, 3184, 1322]}}, "Olfactory signaling pathway": {"direction": "dw", "overlap": {"value": 1, "mean": 0.7956989247311828, "std": 0.4031899625645736, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -2.21706017551406, "mean": -1.3868077475591274, "std": 2.015279555764287, "bin": {}}, "pval": {"value": 0.0266189797224776, "mean": 0.1080106658510623, "std": 0.1791175368367055, "bin": {}}, "signature_idxs": {"edge": [1822], "full": [1822]}}, "Sensory perception of taste": {"direction": "dw", "overlap": {"value": 1, "mean": 0.8505747126436781, "std": 0.3565071820522027, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -2.21706017551406, "mean": -1.6819775448074494, "std": 1.707206719050078, "bin": {}}, "pval": {"value": 0.0266189797224776, "mean": 0.1135909614813741, "std": 0.1836971264080407, "bin": {}}, "signature_idxs": {"edge": [1822], "full": [1822]}}, "Activation of the phototransduction cascade": {"direction": "dw", "overlap": {"value": 1, "mean": 0.8505747126436781, "std": 0.3565071820522027, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -2.21706017551406, "mean": -1.6819775448074494, "std": 1.707206719050078, "bin": {}}, "pval": {"value": 0.0266189797224776, "mean": 0.1135909614813741, "std": 0.1836971264080407, "bin": {}}, "signature_idxs": {"edge": [1822], "full": [1822]}}, "Rhobtb2 gtpase cycle": {"direction": "dw", "overlap": {"value": 4, "mean": 6.422330097087379, "std": 3.686275570322477, "bin": {}}, "setsize": {"value": 21, "mean": 19.48543689320388, "std": 0.801867694458126, "bin": {}}, "score": {"value": -2.216548999028983, "mean": -0.1242529060034592, "std": 0.6453603740142236, "bin": {}}, "pval": {"value": 0.0266539260121996, "mean": 0.6910241740886622, "std": 0.2800414760213386, "bin": {}}, "signature_idxs": {"edge": [3193, 3212, 3124, 3094], "full": [1027, 1237, 3124, 878, 2121, 3193, 733, 3094, 530, 1667, 1191, 2532, 3212, 1063, 991, 1068, 2870, 2161, 775, 1308, 2025]}}, "Cellular responses to stimuli": {"direction": "up", "overlap": {"value": 138, "mean": 79.35922330097087, "std": 30.40123412445525, "bin": {"bin_50": 6, "bin_100": 11, "bin_250": 31, "bin_500": 67}}, "setsize": {"value": 329, "mean": 320.6504854368932, "std": 17.751225166449277, "bin": {"bin_50": 614, "bin_100": 614, "bin_250": 614, "bin_500": 614}}, "score": {"value": 2.21479049959232, "mean": -0.3721602751517567, "std": 0.7923867476625511, "bin": {"bin_50": 2.189182986536108, "bin_100": 1.9680762852404643, "bin_250": 2.294780691007106, "bin_500": 2.6006311583537287}}, "pval": {"value": 0.0267744476210725, "mean": 0.6513525581346685, "std": 0.3338654522470946, "bin": {"bin_50": 0.0723238544076558, "bin_100": 0.0353744276882809, "bin_250": 8.372175053813379e-05, "bin_500": 2.655460776672254e-10}}, "signature_idxs": {"edge": [8, 12, 565, 21, 513, 26, 510, 514, 515, 516, 43, 533, 529, 527, 526, 48, 62, 608, 71, 604, 639, 79, 605, 603, 86, 84, 581, 101, 568, 602, 104, 115, 601, 591, 590, 589, 592, 143, 127, 682, 681, 680, 133, 713, 712, 151, 150, 679, 153, 651, 657, 181, 180, 676, 179, 656, 169, 669, 670, 204, 202, 236, 773, 716, 224, 225, 226, 227, 721, 269, 270, 719, 749, 747, 738, 258, 832, 302, 300, 861, 855, 830, 296, 297, 298, 299, 293, 797, 803, 342, 802, 800, 799, 818, 821, 817, 815, 814, 813, 385, 816, 379, 381, 929, 916, 364, 912, 368, 370, 371, 942, 373, 887, 878, 905, 401, 903, 902, 405, 901, 407, 907, 409, 899, 416, 412, 477, 456, 457, 458, 468, 462, 471, 469, 470, 465, 464, 545], "full": [1088, 568, 26, 2927, 1024, 2455, 1629, 1868, 169, 958, 1548, 1167, 1328, 2459, 1798, 3214, 2688, 651, 1555, 127, 1639, 1950, 1173, 1032, 510, 2932, 716, 1235, 2960, 3123, 401, 3022, 2118, 581, 3091, 84, 1955, 2993, 719, 1237, 878, 2410, 965, 721, 656, 2411, 1239, 43, 2332, 657, 1241, 2639, 2898, 2470, 2122, 405, 1242, 1484, 1647, 797, 2412, 1038, 456, 364, 1561, 1040, 1562, 3213, 1563, 1961, 513, 589, 1247, 887, 590, 115, 407, 224, 457, 799, 591, 2901, 514, 515, 458, 225, 516, 592, 79, 1406, 1248, 1042, 2996, 2753, 800, 1249, 368, 973, 462, 21, 1494, 1733, 2805, 370, 371, 1255, 669, 1256, 1495, 2806, 1409, 1654, 409, 670, 2342, 2525, 86, 802, 2343, 373, 974, 894, 226, 464, 803, 293, 2701, 8, 465, 150, 1258, 1571, 227, 738, 2265, 2755, 2702, 1259, 2649, 1736, 412, 526, 101, 296, 2527, 1739, 979, 297, 676, 202, 2528, 468, 527, 1121, 899, 151, 1189, 813, 1503, 1578, 469, 104, 814, 298, 982, 601, 470, 1579, 901, 471, 815, 816, 679, 902, 179, 299, 817, 818, 416, 1351, 1123, 180, 48, 903, 602, 1420, 680, 603, 681, 300, 1124, 133, 604, 605, 2135, 2810, 181, 529, 1421, 302, 2136, 379, 1050, 153, 1051, 1666, 682, 905, 1974, 747, 2423, 258, 1128, 821, 749, 3189, 2588, 907, 3167, 381, 2811, 2589, 533, 1430, 1275, 608, 1057, 1276, 1191, 1978, 236, 2425, 1431, 1676, 1980, 2358, 204, 912, 2359, 1507, 3067, 830, 832, 477, 2278, 3190, 1679, 3004, 2488, 916, 1282, 1986, 2969, 2710, 3009, 2663, 1603, 1202, 2434, 3105, 1441, 2771, 385, 342, 1759, 2231, 2437, 3158, 1288, 2073, 2773, 71, 929, 1446, 2915, 2373, 545, 1372, 1922, 12, 269, 1923, 2079, 270, 2080, 2376, 2670, 855, 1209, 1377, 2779, 773, 2164, 2781, 143, 2782, 2676, 2919, 3116, 1381, 2387, 2242, 2979, 2557, 2306, 1467, 942, 1620, 861, 2023, 2844, 2248, 1782, 3120, 3169, 2312, 712, 62, 713, 639, 1221, 2955, 2395, 565, 1319, 2987, 2321, 1322, 3058]}}, "Death receptor signalling": {"direction": "up", "overlap": {"value": 5, "mean": 5.645631067961165, "std": 3.539054689729852, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 5, "bin_500": 6}}, "setsize": {"value": 22, "mean": 23.54126213592233, "std": 5.442171393384637, "bin": {"bin_50": 120, "bin_100": 120, "bin_250": 120, "bin_500": 120}}, "score": {"value": 2.2137905969195013, "mean": -0.1102863609457894, "std": 0.8141573628490125, "bin": {"bin_50": 1.7556022408963583, "bin_100": 0.855599382610187, "bin_250": 1.7593487207013776, "bin_500": 1.0252460419341036}}, "pval": {"value": 0.0268431872202883, "mean": 0.6465088441574995, "std": 0.3087559956450991, "bin": {"bin_50": 0.4409382257745535, "bin_100": 0.6920373866615517, "bin_250": 0.1680099051588612, "bin_500": 0.5361206282257731}}, "signature_idxs": {"edge": [229, 190, 189, 184, 28], "full": [1631, 1225, 672, 28, 1497, 229, 1969, 1579, 904, 301, 1747, 535, 909, 2481, 1196, 184, 1695, 189, 999, 190, 1934, 3087]}}, "Processive synthesis on the lagging strand": {"direction": "up", "overlap": {"value": 8, "mean": 5.337378640776699, "std": 2.903004958430143, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 3, "bin_500": 5}}, "setsize": {"value": 14, "mean": 12.490291262135925, "std": 1.8014026122655222, "bin": {"bin_50": 17, "bin_100": 17, "bin_250": 17, "bin_500": 17}}, "score": {"value": 2.209128422782581, "mean": -0.4682866917213784, "std": 0.9753460783472956, "bin": {"bin_50": 13.19140625, "bin_100": 6.4292091836734695, "bin_250": 8.688629737609329, "bin_500": 8.186274509803921}}, "pval": {"value": 0.0271657096748374, "mean": 0.4841203144335685, "std": 0.3256071087002858, "bin": {"bin_50": 0.0786913117950012, "bin_100": 0.152955667850895, "bin_250": 0.0075105395483816, "bin_500": 0.0010331595236533}}, "signature_idxs": {"edge": [737, 252, 130, 131, 729, 21, 260, 591], "full": [1482, 252, 1242, 1104, 591, 729, 21, 130, 805, 737, 131, 260, 990, 2790]}}, "Ubiquinol biosynthesis": {"direction": "dw", "overlap": {"value": 2, "mean": 0.7643504531722054, "std": 0.7488547859736394, "bin": {}}, "setsize": {"value": 2, "mean": 1.782477341389728, "std": 0.8661795279052236, "bin": {}}, "score": {"value": -2.2090323491638872, "mean": 0.1703193341170159, "std": 1.6639673165875473, "bin": {}}, "pval": {"value": 0.0271723909264154, "mean": 0.3322144330238493, "std": 0.3079076774660819, "bin": {}}, "signature_idxs": {"edge": [2664, 3156], "full": [3156, 2664]}}, "Lgi adam interactions": {"direction": "up", "overlap": {"value": 0, "mean": 0.5905292479108635, "std": 0.491736164292086, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {"bin_50": 5, "bin_100": 5, "bin_250": 5, "bin_500": 5}}, "score": {"value": 2.199851693734457, "mean": -0.3426612697332495, "std": 1.799502532654131, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0278174189524791, "mean": 0.2685155599480251, "std": 0.2730254682047677, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1355]}}, "Met interacts with tns proteins": {"direction": "dw", "overlap": {"value": 2, "mean": 1.0121359223300972, "std": 0.6663538674538861, "bin": {}}, "setsize": {"value": 2, "mean": 1.805825242718447, "std": 0.3955640541255022, "bin": {}}, "score": {"value": -2.175474013026584, "mean": -0.3491119361165427, "std": 1.251763787093182, "bin": {}}, "pval": {"value": 0.029594613446688, "mean": 0.4962767341249235, "std": 0.3342400492543962, "bin": {}}, "signature_idxs": {"edge": [2576, 2980], "full": [2576, 2980]}}, "Nr1h2 nr1h3 regulate gene expression to control bile acid homeostasis": {"direction": "dw", "overlap": {"value": 1, "mean": 0.6797752808988764, "std": 0.5744914263411839, "bin": {}}, "setsize": {"value": 1, "mean": 1.1348314606741574, "std": 0.3415434641251835, "bin": {}}, "score": {"value": -2.175262668577833, "mean": -0.4519646380347663, "std": 1.9945078005689256, "bin": {}}, "pval": {"value": 0.0296104383396826, "mean": 0.2751969527114593, "std": 0.3140574771322071, "bin": {}}, "signature_idxs": {"edge": [1798], "full": [1798]}}, "Synthesis of gdp mannose": {"direction": "up", "overlap": {"value": 1, "mean": 1.194174757281553, "std": 0.6691285801985545, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 2, "mean": 2.483009708737864, "std": 0.7582572442446097, "bin": {"bin_50": 5, "bin_100": 5, "bin_250": 5, "bin_500": 5}}, "score": {"value": 2.1552837712769537, "mean": -0.9088397987217202, "std": 1.1898194901024377, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0311396349590344, "mean": 0.3919435617537425, "std": 0.3169265686665075, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [622], "full": [594, 622]}}, "Regulation of pten localization": {"direction": "up", "overlap": {"value": 0, "mean": 0.6262135922330098, "std": 0.6690757521726134, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.6796116504854368, "std": 0.7269245261100925, "bin": {"bin_50": 8, "bin_100": 8, "bin_250": 8, "bin_500": 8}}, "score": {"value": 2.154155720374477, "mean": 0.4208087684335465, "std": 1.2913453027527038, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0312279620446842, "mean": 0.4440544856190916, "std": 0.3230766517067426, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1448]}}, "Pd 1 signaling": {"direction": "up", "overlap": {"value": 1, "mean": 1.1820388349514563, "std": 0.6850467480658059, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 2, "mean": 1.9344660194174756, "std": 0.2474657106985401, "bin": {"bin_50": 5, "bin_100": 5, "bin_250": 5, "bin_500": 5}}, "score": {"value": 2.1482831897687302, "mean": -0.3613106948111595, "std": 1.1339521563995252, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 10.064777327935223, "bin_500": 4.8762575452716295}}, "pval": {"value": 0.031691265484266, "mean": 0.5599444626679578, "std": 0.3374026427800802, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1158638926054548, "bin_500": 0.2215335762210877}}, "signature_idxs": {"edge": [116], "full": [597, 116]}}, "Polymerase switching": {"direction": "up", "overlap": {"value": 9, "mean": 4.618932038834951, "std": 3.0557809014573305, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 6}}, "setsize": {"value": 14, "mean": 13.230582524271844, "std": 1.227807522028966, "bin": {"bin_50": 16, "bin_100": 16, "bin_250": 16, "bin_500": 16}}, "score": {"value": 2.14501667138436, "mean": -0.2023566630751481, "std": 0.8207986835476901, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 2.6809716599190283, "bin_500": 11.814634146341463}}, "pval": {"value": 0.0319515140695982, "mean": 0.5838533722961434, "std": 0.295099891152963, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.3258327648280404, "bin_500": 6.933879980949677e-05}}, "signature_idxs": {"edge": [369, 737, 252, 729, 329, 131, 260, 292, 805], "full": [1482, 252, 729, 329, 369, 2043, 292, 1496, 805, 737, 131, 260, 990, 2790]}}, "Transcriptional regulation by ventx": {"direction": "dw", "overlap": {"value": 8, "mean": 4.825242718446602, "std": 3.0021907356016566, "bin": {}}, "setsize": {"value": 13, "mean": 13.4247572815534, "std": 2.2102296786419937, "bin": {}}, "score": {"value": -2.1440517989465087, "mean": 0.1564173965756505, "std": 0.7096790241806044, "bin": {}}, "pval": {"value": 0.0320287365914189, "mean": 0.6419411264518197, "std": 0.2885978432586358, "bin": {}}, "signature_idxs": {"edge": [3169, 3120, 2996, 2524, 2919, 3022, 2588, 2844], "full": [3022, 2996, 2524, 802, 2588, 269, 2919, 1381, 2844, 2248, 1782, 3120, 3169]}}, "Nuclear envelope ne reassembly": {"direction": "dw", "overlap": {"value": 21, "mean": 12.87621359223301, "std": 5.145147325677084, "bin": {}}, "setsize": {"value": 49, "mean": 48.432038834951456, "std": 2.769063267087378, "bin": {}}, "score": {"value": -2.143196037897795, "mean": 0.3029395053279946, "std": 0.8345402449033724, "bin": {}}, "pval": {"value": 0.0320973603077237, "mean": 0.6511236784131957, "std": 0.3415462759835261, "bin": {}}, "signature_idxs": {"edge": [2528, 2527, 2609, 3213, 2601, 2688, 2871, 2958, 2960, 2969, 3009, 2771, 2773, 2781, 2782, 2915, 3157, 2676, 3189, 2526, 2940], "full": [2958, 2688, 2402, 2960, 401, 511, 726, 1560, 3213, 665, 669, 1734, 2046, 1109, 2526, 2527, 1047, 202, 2528, 983, 528, 302, 3189, 236, 2940, 1058, 2969, 3009, 2601, 2771, 3157, 1759, 2231, 2437, 2773, 268, 2871, 2915, 1525, 2079, 2609, 209, 2781, 143, 2782, 2676, 352, 1625, 2316]}}, "Traf6 mediated induction of tak1 complex within tlr4 complex": {"direction": "up", "overlap": {"value": 0, "mean": 1.1276041666666667, "std": 0.7885036524852874, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 2, "mean": 1.9088541666666667, "std": 0.7803075913163809, "bin": {"bin_50": 11, "bin_100": 11, "bin_250": 11, "bin_500": 11}}, "score": {"value": 2.139208488560401, "mean": -0.5531731964273906, "std": 1.4201475296966142, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 4.023481781376519, "bin_500": 1.9492957746478876}}, "pval": {"value": 0.0324187870245751, "mean": 0.4146354267394658, "std": 0.3339694754795695, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.2373820829012167, "bin_500": 0.4236908718837023}}, "signature_idxs": {"edge": [], "full": [1196, 136]}}, "Mrna editing": {"direction": "dw", "overlap": {"value": 2, "mean": 0.7669902912621359, "std": 0.5652370152430625, "bin": {}}, "setsize": {"value": 2, "mean": 1.2912621359223302, "std": 0.4543440371571879, "bin": {}}, "score": {"value": -2.1389906432470185, "mean": -0.5685103039499756, "std": 1.4394536217468417, "bin": {}}, "pval": {"value": 0.0324364261667047, "mean": 0.3885454733263489, "std": 0.3248014425681872, "bin": {}}, "signature_idxs": {"edge": [2618, 2757], "full": [2757, 2618]}}, "Negative regulation of flt3": {"direction": "up", "overlap": {"value": 1, "mean": 0.9148418491484184, "std": 0.616124503012299, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 2, "mean": 1.5474452554744529, "std": 0.4977438575542283, "bin": {"bin_50": 8, "bin_100": 8, "bin_250": 8, "bin_500": 8}}, "score": {"value": 2.134267762450704, "mean": -0.4381864685898667, "std": 1.322755984486338, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0328208685833961, "mean": 0.4649612511290132, "std": 0.339104728071455, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [597], "full": [587, 597]}}, "Mitochondrial biogenesis": {"direction": "dw", "overlap": {"value": 21, "mean": 10.572815533980584, "std": 4.798567629623383, "bin": {}}, "setsize": {"value": 36, "mean": 33.521844660194176, "std": 2.9315837025395943, "bin": {}}, "score": {"value": -2.131157288871249, "mean": 0.7125383902440768, "std": 1.2191838320541302, "bin": {}}, "pval": {"value": 0.033076186369481, "mean": 0.3998427377933914, "std": 0.3355715376706868, "bin": {}}, "signature_idxs": {"edge": [3061, 2226, 2737, 2795, 2006, 2488, 2244, 2196, 2699, 2511, 3123, 1966, 2205, 1963, 3146, 3025, 1983, 2117, 3045, 2086, 2400], "full": [1545, 1798, 2400, 1096, 2795, 2117, 3123, 3146, 3061, 2196, 2699, 1963, 1495, 735, 1812, 1499, 1500, 1966, 2205, 3045, 3025, 380, 1274, 1679, 2488, 1983, 834, 2226, 1202, 1919, 2006, 2086, 2244, 2737, 1539, 2511]}}, "G protein beta gamma signalling": {"direction": "dw", "overlap": {"value": 2, "mean": 1.7718446601941749, "std": 1.246892640696441, "bin": {}}, "setsize": {"value": 6, "mean": 5.211165048543689, "std": 1.573929471884848, "bin": {}}, "score": {"value": -2.1310387805821747, "mean": 0.0136852380664441, "std": 0.9420889570977656, "bin": {}}, "pval": {"value": 0.0330859474406053, "mean": 0.5590401988123619, "std": 0.3179818542906523, "bin": {}}, "signature_idxs": {"edge": [3047, 3129], "full": [1661, 1969, 1822, 1504, 3047, 3129]}}, "Diseases associated with n glycosylation of proteins": {"direction": "dw", "overlap": {"value": 3, "mean": 2.2475728155339807, "std": 1.5924179977786468, "bin": {}}, "setsize": {"value": 6, "mean": 5.725728155339806, "std": 1.7320559095113808, "bin": {}}, "score": {"value": -2.1246355821365728, "mean": 0.3341088995719526, "std": 1.1764326310317936, "bin": {}}, "pval": {"value": 0.0336170324175739, "mean": 0.3985277581822796, "std": 0.3016026507368399, "bin": {}}, "signature_idxs": {"edge": [3143, 3187, 3115], "full": [960, 3143, 1977, 917, 3187, 3115]}}, "Tyrosine catabolism": {"direction": "up", "overlap": {"value": 0, "mean": 0.9874371859296482, "std": 0.7105401475854651, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 2, "mean": 1.7738693467336684, "std": 0.4183247314224605, "bin": {"bin_50": 2, "bin_100": 2, "bin_250": 2, "bin_500": 2}}, "score": {"value": 2.1242755373755124, "mean": -0.3991126530991996, "std": 1.392292312826279, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 40.27125506072875, "bin_500": 19.51106639839034}}, "pval": {"value": 0.0336471100357702, "mean": 0.4114004894420165, "std": 0.3270107260508794, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0480572346493884, "bin_500": 0.095304315936589}}, "signature_idxs": {"edge": [], "full": [170, 1884]}}, "Transport of connexons to the plasma membrane": {"direction": "up", "overlap": {"value": 3, "mean": 2.7063106796116503, "std": 1.3523295185638555, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 2, "bin_500": 4}}, "setsize": {"value": 4, "mean": 4.587378640776699, "std": 0.9949561742458796, "bin": {"bin_50": 14, "bin_100": 14, "bin_250": 14, "bin_500": 14}}, "score": {"value": 2.1230418306724905, "mean": 0.4995785603281155, "std": 1.150433862709782, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 6.7317073170731705, "bin_500": 7.844534412955466}}, "pval": {"value": 0.0337503467206128, "mean": 0.4095483585324659, "std": 0.3070287716914409, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0442367692127036, "bin_500": 0.0038035060050311}}, "signature_idxs": {"edge": [143, 302, 236], "full": [401, 302, 236, 143]}}, "Gap junction assembly": {"direction": "up", "overlap": {"value": 3, "mean": 2.7184466019417477, "std": 1.37358913126072, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 2, "bin_500": 4}}, "setsize": {"value": 4, "mean": 4.604368932038835, "std": 1.0102774490620512, "bin": {"bin_50": 15, "bin_100": 15, "bin_250": 15, "bin_500": 15}}, "score": {"value": 2.1230418306724905, "mean": 0.499967666973865, "std": 1.1493312724073153, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 6.213258286429018, "bin_500": 7.130658814869341}}, "pval": {"value": 0.0337503467206128, "mean": 0.4121155936503509, "std": 0.3091304616480874, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.050241067872642, "bin_500": 0.004988841333209}}, "signature_idxs": {"edge": [143, 302, 236], "full": [401, 302, 236, 143]}}, "Mhc class ii antigen presentation": {"direction": "up", "overlap": {"value": 14, "mean": 14.065533980582524, "std": 7.205585512568872, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 6, "bin_500": 13}}, "setsize": {"value": 55, "mean": 53.91990291262136, "std": 4.251886159447844, "bin": {"bin_50": 100, "bin_100": 100, "bin_250": 100, "bin_500": 100}}, "score": {"value": 2.114585602654232, "mean": 0.0378305751056327, "std": 0.7481875393236335, "bin": {"bin_50": 2.114478114478114, "bin_100": 1.0305091733663163, "bin_250": 2.5990856339018813, "bin_500": 2.961085436663112}}, "pval": {"value": 0.0344652818091657, "mean": 0.7050016235886306, "std": 0.3070805603530936, "bin": {"bin_50": 0.3837477700868037, "bin_100": 0.624878431747349, "bin_250": 0.0349265103093486, "bin_500": 0.0011124995614419}}, "signature_idxs": {"edge": [475, 143, 465, 608, 8, 302, 401, 127, 390, 236, 202, 270, 296, 169], "full": [870, 169, 1549, 127, 874, 2635, 1639, 2990, 1641, 963, 578, 2572, 401, 2119, 1558, 1879, 2125, 1251, 8, 465, 1415, 1261, 1817, 296, 1574, 675, 1346, 202, 1049, 1121, 2052, 2135, 302, 1824, 3155, 475, 1899, 2589, 608, 236, 1431, 1676, 1903, 1433, 2000, 270, 933, 143, 1211, 390, 2090, 942, 2023, 1320, 1322]}}, "Traf6 mediated irf7 activation in tlr7 8 or 9 signaling": {"direction": "up", "overlap": {"value": 0, "mean": 0.6199460916442049, "std": 0.5767564265186361, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 2, "mean": 1.2291105121293802, "std": 0.4202604970267765, "bin": {"bin_50": 10, "bin_100": 10, "bin_250": 10, "bin_500": 10}}, "score": {"value": 2.1095736232615923, "mean": -0.0086228474039033, "std": 1.6651051661096277, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 4.470985155195682, "bin_500": 2.1661077576570533}}, "pval": {"value": 0.0348950982898124, "mean": 0.3414486618405348, "std": 0.3130134606450676, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.2183511668733661, "bin_500": 0.3940663935801297}}, "signature_idxs": {"edge": [], "full": [103, 1131]}}, "Carboxyterminal post translational modifications of tubulin": {"direction": "up", "overlap": {"value": 3, "mean": 3.2111650485436893, "std": 1.6044754161745491, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 2, "bin_500": 4}}, "setsize": {"value": 6, "mean": 5.764563106796117, "std": 1.1192952677926271, "bin": {"bin_50": 25, "bin_100": 25, "bin_250": 25, "bin_500": 25}}, "score": {"value": 2.107411206796713, "mean": 0.4532219515804401, "std": 1.149295682796638, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 3.508306822198657, "bin_500": 3.731251204935416}}, "pval": {"value": 0.0350819510252715, "mean": 0.4130550911105556, "std": 0.3146953714506392, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1227655047468798, "bin_500": 0.0314674363117242}}, "signature_idxs": {"edge": [143, 302, 236], "full": [401, 302, 236, 1193, 1830, 143]}}, "Dex h box helicases activate type i ifn and inflammatory cytokines production": {"direction": "dw", "overlap": {"value": 1, "mean": 1.364077669902913, "std": 0.832280102324132, "bin": {}}, "setsize": {"value": 2, "mean": 2.3980582524271843, "std": 0.523056844545669, "bin": {}}, "score": {"value": -2.1040463573962938, "mean": -0.3393404509156783, "std": 0.9139030777692736, "bin": {}}, "pval": {"value": 0.0353744034204546, "mean": 0.5994179890713632, "std": 0.3167193898280874, "bin": {}}, "signature_idxs": {"edge": [3049], "full": [3049, 1931]}}, "Caspase activation via dependence receptors in the absence of ligand": {"direction": "up", "overlap": {"value": 0, "mean": 0.7091503267973857, "std": 0.7477949700761132, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 2, "mean": 1.5163398692810457, "std": 0.7240461398235937, "bin": {"bin_50": 7, "bin_100": 7, "bin_250": 7, "bin_500": 7}}, "score": {"value": 2.098950293302049, "mean": -0.00576997843107, "std": 1.7377048293968946, "bin": {"bin_50": 35.21180555555556, "bin_100": 17.16156462585034, "bin_250": 6.708502024291498, "bin_500": 3.250167672702884}}, "pval": {"value": 0.0358212827102115, "mean": 0.3448524870506525, "std": 0.3209204826661431, "bin": {"bin_50": 0.0331691185540615, "bin_100": 0.0660385900079411, "bin_250": 0.1583736196074974, "bin_500": 0.295760276625992}}, "signature_idxs": {"edge": [], "full": [672, 14]}}, "Runx3 regulates cdkn1a transcription": {"direction": "dw", "overlap": {"value": 1, "mean": 0.7087378640776699, "std": 0.5553109504350763, "bin": {}}, "setsize": {"value": 2, "mean": 1.1383495145631068, "std": 0.3452664570780942, "bin": {}}, "score": {"value": -2.0984464776978045, "mean": -0.4855351621994475, "std": 1.4669467149916913, "bin": {}}, "pval": {"value": 0.0358657232256507, "mean": 0.3703629972811378, "std": 0.3085607407920848, "bin": {}}, "signature_idxs": {"edge": [3022], "full": [3022, 1273]}}, "Raf independent mapk1 3 activation": {"direction": "up", "overlap": {"value": 4, "mean": 2.8737864077669903, "std": 1.7076618412575413, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 2}}, "setsize": {"value": 6, "mean": 6.053398058252427, "std": 0.9961396882178882, "bin": {"bin_50": 15, "bin_100": 15, "bin_250": 15, "bin_500": 15}}, "score": {"value": 2.0978604473355995, "mean": -0.0384579769135277, "std": 0.8641301644107567, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 2.872758820127242, "bin_500": 3.004032258064516}}, "pval": {"value": 0.0359174748759136, "mean": 0.5688702072101578, "std": 0.3009573249600672, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.3090006421698555, "bin_500": 0.1646547004840289}}, "signature_idxs": {"edge": [511, 116, 304, 549], "full": [511, 516, 1179, 304, 116, 549]}}, "Signaling by csf3 g csf": {"direction": "up", "overlap": {"value": 5, "mean": 3.0364077669902914, "std": 1.6840585248973623, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 2, "bin_500": 4}}, "setsize": {"value": 8, "mean": 7.060679611650485, "std": 0.9392764847620928, "bin": {"bin_50": 22, "bin_100": 22, "bin_250": 22, "bin_500": 22}}, "score": {"value": 2.096344816659927, "mean": -0.5148684686308064, "std": 0.8642346502701144, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 4.035772357723578, "bin_500": 4.354475933423302}}, "pval": {"value": 0.0360516138210718, "mean": 0.4954635047946266, "std": 0.307664299011297, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0990342687178565, "bin_500": 0.0204068190514482}}, "signature_idxs": {"edge": [521, 219, 409, 116, 477], "full": [219, 409, 521, 1266, 116, 832, 477, 1526]}}, "Signaling by scf kit": {"direction": "up", "overlap": {"value": 6, "mean": 3.162621359223301, "std": 2.0205884277841544, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 3, "bin_500": 5}}, "setsize": {"value": 12, "mean": 7.449029126213592, "std": 1.9718465125497413, "bin": {"bin_50": 31, "bin_100": 31, "bin_250": 31, "bin_500": 31}}, "score": {"value": 2.0900295684621315, "mean": -0.2820568683803559, "std": 0.7593000484496075, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 4.338192419825073, "bin_500": 3.7728194726166326}}, "pval": {"value": 0.0366151436638986, "mean": 0.5745805911328579, "std": 0.2853080859137487, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0387286577629364, "bin_500": 0.016158457458282}}, "signature_idxs": {"edge": [521, 219, 409, 201, 116, 357], "full": [357, 1726, 1238, 219, 201, 587, 409, 521, 1266, 904, 116, 2811]}}, "Signaling by fgfr3": {"direction": "up", "overlap": {"value": 4, "mean": 2.7524271844660193, "std": 1.7850155507845185, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 2, "bin_500": 2}}, "setsize": {"value": 9, "mean": 6.422330097087379, "std": 1.3315756079824297, "bin": {"bin_50": 27, "bin_100": 27, "bin_250": 27, "bin_500": 27}}, "score": {"value": 2.088954737488451, "mean": -0.1651967922037998, "std": 0.8968234015805969, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 3.2269918699186992, "bin_500": 1.5601612903225806}}, "pval": {"value": 0.0367117977783251, "mean": 0.5356361694616106, "std": 0.2979290780410805, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1392702662277763, "bin_500": 0.3827254031641982}}, "signature_idxs": {"edge": [587, 116, 516, 201], "full": [1726, 201, 1485, 587, 516, 665, 1266, 116, 1303]}}, "Signaling by fgfr4": {"direction": "up", "overlap": {"value": 4, "mean": 2.7524271844660193, "std": 1.7850155507845185, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 2, "bin_500": 2}}, "setsize": {"value": 9, "mean": 6.422330097087379, "std": 1.3315756079824297, "bin": {"bin_50": 26, "bin_100": 26, "bin_250": 26, "bin_500": 26}}, "score": {"value": 2.088954737488451, "mean": -0.1651967922037998, "std": 0.8968234015805969, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 3.361788617886179, "bin_500": 1.6253360215053765}}, "pval": {"value": 0.0367117977783251, "mean": 0.5356361694616106, "std": 0.2979290780410805, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1309570889500886, "bin_500": 0.3649620055651655}}, "signature_idxs": {"edge": [587, 116, 516, 201], "full": [1726, 201, 1485, 587, 516, 665, 1266, 116, 1303]}}, "Signaling by fgfr1": {"direction": "up", "overlap": {"value": 4, "mean": 2.7524271844660193, "std": 1.7850155507845185, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 2, "bin_500": 2}}, "setsize": {"value": 9, "mean": 6.422330097087379, "std": 1.3315756079824297, "bin": {"bin_50": 28, "bin_100": 28, "bin_250": 28, "bin_500": 28}}, "score": {"value": 2.088954737488451, "mean": -0.1651967922037998, "std": 0.8968234015805969, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 3.102564102564102, "bin_500": 1.5}}, "pval": {"value": 0.0367117977783251, "mean": 0.5356361694616106, "std": 0.2979290780410805, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1476943407876319, "bin_500": 0.4002722624509632}}, "signature_idxs": {"edge": [587, 116, 516, 201], "full": [1726, 201, 1485, 587, 516, 665, 1266, 116, 1303]}}, "Hsf1 activation": {"direction": "up", "overlap": {"value": 7, "mean": 6.262135922330097, "std": 3.5057820895194016, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 14, "mean": 13.847087378640778, "std": 1.0536189424360778, "bin": {"bin_50": 25, "bin_100": 25, "bin_250": 25, "bin_500": 25}}, "score": {"value": 2.084432997752724, "mean": -0.4333250288126234, "std": 0.9971080545369552, "bin": {"bin_50": 8.78732638888889, "bin_100": 4.282738095238095, "bin_250": 1.674089068825911, "bin_500": 0.8110328638497653}}, "pval": {"value": 0.0371207989220447, "mean": 0.4743355436386303, "std": 0.3169703406464311, "bin": {"bin_50": 0.1135912525516411, "bin_100": 0.2166826538338764, "bin_250": 0.4600796867443816, "bin_500": 0.714470118842069}}, "signature_idxs": {"edge": [929, 682, 887, 21, 676, 830, 591], "full": [2118, 1237, 878, 1239, 1242, 887, 591, 21, 1736, 676, 1579, 682, 830, 929]}}, "Methionine salvage pathway": {"direction": "up", "overlap": {"value": 1, "mean": 0.7839805825242718, "std": 0.8809944070503681, "bin": {"bin_50": 0, "bin_100": 1, "bin_250": 2, "bin_500": 2}}, "setsize": {"value": 3, "mean": 3.5728155339805827, "std": 0.7517221877300719, "bin": {"bin_50": 6, "bin_100": 6, "bin_250": 6, "bin_500": 6}}, "score": {"value": 2.0778642661408866, "mean": 0.7306689139041258, "std": 0.9093507287103676, "bin": {"bin_50": 0.0, "bin_100": 20.59591836734694, "bin_250": 20.211382113821134, "bin_500": 9.772177419354838}}, "pval": {"value": 0.0377218625850739, "mean": 0.4385514753045822, "std": 0.3017277391547502, "bin": {"bin_50": 1.0, "bin_100": 0.0568757538574934, "bin_250": 0.0082857576662697, "bin_500": 0.0313283564047791}}, "signature_idxs": {"edge": [81], "full": [1243, 81, 144]}}, "Factors involved in megakaryocyte development and platelet production": {"direction": "up", "overlap": {"value": 19, "mean": 12.805825242718448, "std": 6.829132700803817, "bin": {"bin_50": 2, "bin_100": 2, "bin_250": 5, "bin_500": 11}}, "setsize": {"value": 43, "mean": 44.49271844660194, "std": 4.981757535652317, "bin": {"bin_50": 117, "bin_100": 117, "bin_250": 117, "bin_500": 117}}, "score": {"value": 2.074436783539124, "mean": -0.1851230754516618, "std": 0.6447331520495331, "bin": {"bin_50": 3.712118408880666, "bin_100": 1.7896907216494846, "bin_250": 1.8070252792475012, "bin_500": 2.043934756499167}}, "pval": {"value": 0.0380387641174484, "mean": 0.703414804631471, "std": 0.2863813279221834, "bin": {"bin_50": 0.1084777994315797, "bin_100": 0.3146455165791138, "bin_250": 0.1561677996643208, "bin_500": 0.0276073850385152}}, "signature_idxs": {"edge": [730, 143, 6, 8, 554, 870, 909, 302, 401, 531, 296, 753, 236, 475, 220, 390, 465, 933, 589], "full": [870, 2325, 2403, 2990, 1641, 401, 3022, 220, 1483, 1403, 1960, 589, 730, 1251, 2474, 8, 465, 1817, 296, 1661, 904, 302, 531, 3155, 475, 1746, 909, 753, 236, 1903, 1914, 1851, 1695, 1529, 2670, 933, 143, 390, 2090, 554, 6, 2249, 1320]}}, "Folding of actin by cct tric": {"direction": "up", "overlap": {"value": 7, "mean": 5.461165048543689, "std": 2.1043059418798453, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 3}}, "setsize": {"value": 8, "mean": 8.0, "std": 0.0, "bin": {"bin_50": 10, "bin_100": 10, "bin_250": 10, "bin_500": 10}}, "score": {"value": 2.0744204094608363, "mean": -0.4692686565402915, "std": 0.968912135079772, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 8.39047619047619}}, "pval": {"value": 0.03804028346521, "mean": 0.4573595711033881, "std": 0.3098429291835972, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.0107435842434709}}, "signature_idxs": {"edge": [733, 662, 775, 530, 376, 466, 294], "full": [662, 733, 294, 466, 376, 895, 530, 775]}}, "Pyrimidine salvage": {"direction": "up", "overlap": {"value": 1, "mean": 1.367396593673966, "std": 0.9168908564891776, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 2, "mean": 2.4184914841849148, "std": 0.7513482847929452, "bin": {"bin_50": 9, "bin_100": 9, "bin_250": 9, "bin_500": 9}}, "score": {"value": 2.073786595611942, "mean": -0.2171353905575207, "std": 1.1790748869071406, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 2.437122736418511}}, "pval": {"value": 0.0380991346126133, "mean": 0.4898796128753721, "std": 0.3172797889586038, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.3629223192764827}}, "signature_idxs": {"edge": [345], "full": [653, 345]}}, "Biotin transport and metabolism": {"direction": "dw", "overlap": {"value": 5, "mean": 5.116504854368932, "std": 1.4145634399717075, "bin": {}}, "setsize": {"value": 8, "mean": 8.03640776699029, "std": 0.9533460280821764, "bin": {}}, "score": {"value": -2.0719737221528542, "mean": -2.0531807267583235, "std": 1.4870488903095456, "bin": {}}, "pval": {"value": 0.0382678918866405, "mean": 0.1038341457369441, "std": 0.2349123521752051, "bin": {}}, "signature_idxs": {"edge": [2610, 2469, 2798, 2746, 2658], "full": [2746, 2798, 1399, 2469, 1737, 2658, 2610, 1772]}}, "Signaling by erythropoietin": {"direction": "up", "overlap": {"value": 1, "mean": 1.444174757281553, "std": 0.897293691864538, "bin": {"bin_50": 0, "bin_100": 1, "bin_250": 2, "bin_500": 2}}, "setsize": {"value": 5, "mean": 3.4805825242718447, "std": 0.8077967460912242, "bin": {"bin_50": 19, "bin_100": 19, "bin_250": 19, "bin_500": 19}}, "score": {"value": 2.070600667622169, "mean": -0.351796699077687, "std": 0.9567753182552068, "bin": {"bin_50": 0.0, "bin_100": 5.713718820861678, "bin_250": 4.749402199904352, "bin_500": 2.2962523719165087}}, "pval": {"value": 0.0383961297318533, "mean": 0.5283557960675394, "std": 0.3133619735858002, "bin": {"bin_50": 1.0, "bin_100": 0.1693528922958147, "bin_250": 0.0768284795296569, "bin_500": 0.2369865842622187}}, "signature_idxs": {"edge": [65], "full": [1726, 219, 1485, 65, 1266]}}, "Formation of fibrin clot clotting cascade": {"direction": "dw", "overlap": {"value": 1, "mean": 0.6601941747572816, "std": 0.7044022193094001, "bin": {}}, "setsize": {"value": 2, "mean": 2.2475728155339807, "std": 0.4316022666096162, "bin": {}}, "score": {"value": -2.068004519706736, "mean": 0.9518044819862884, "std": 1.3349554740227287, "bin": {}}, "pval": {"value": 0.0386395980956775, "mean": 0.2831140942656386, "std": 0.2564201543424075, "bin": {}}, "signature_idxs": {"edge": [3026], "full": [1889, 3026]}}, "Intrinsic pathway of fibrin clot formation": {"direction": "dw", "overlap": {"value": 1, "mean": 0.5048543689320388, "std": 0.5973044044765835, "bin": {}}, "setsize": {"value": 2, "mean": 2.0, "std": 0.0, "bin": {}}, "score": {"value": -2.068004519706736, "mean": 0.9712627122316906, "std": 1.3782777506658228, "bin": {}}, "pval": {"value": 0.0386395980956775, "mean": 0.2813371943811893, "std": 0.2523512883589371, "bin": {}}, "signature_idxs": {"edge": [3026], "full": [1889, 3026]}}, "Wnt mediated activation of dvl": {"direction": "up", "overlap": {"value": 0, "mean": 1.2135922330097086, "std": 0.8349232327584782, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 2, "mean": 2.4684466019417477, "std": 0.6765665134697751, "bin": {"bin_50": 8, "bin_100": 8, "bin_250": 8, "bin_500": 8}}, "score": {"value": 2.0673254029593195, "mean": -0.0053813907359502, "std": 1.0013706183360802, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 2.785570566254671}}, "pval": {"value": 0.0387035021346531, "mean": 0.5994830854892614, "std": 0.3225906995117547, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.3301808657155594}}, "signature_idxs": {"edge": [], "full": [364, 1421]}}, "Hdl assembly": {"direction": "up", "overlap": {"value": 0, "mean": 0.8347578347578347, "std": 0.5808333594917269, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.3190883190883191, "std": 0.5014568754117789, "bin": {"bin_50": 6, "bin_100": 6, "bin_250": 6, "bin_500": 6}}, "score": {"value": 2.066175851214861, "mean": -0.6061655717207838, "std": 1.5289537665398396, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0388118781829744, "mean": 0.3430953982350836, "std": 0.3243752461452094, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1403]}}, "Pka mediated phosphorylation of key metabolic factors": {"direction": "up", "overlap": {"value": 0, "mean": 0.8347578347578347, "std": 0.5808333594917269, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.3190883190883191, "std": 0.5014568754117789, "bin": {"bin_50": 4, "bin_100": 4, "bin_250": 4, "bin_500": 4}}, "score": {"value": 2.066175851214861, "mean": -0.6061655717207838, "std": 1.5289537665398396, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0388118781829744, "mean": 0.3430953982350836, "std": 0.3243752461452094, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1403]}}, "Tnf receptor superfamily tnfsf members mediating non canonical nf kb pathway": {"direction": "dw", "overlap": {"value": 1, "mean": 0.7972027972027972, "std": 0.4020826996214, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -2.0649575509830824, "mean": -1.0282483236855142, "std": 1.8173413074310416, "bin": {}}, "pval": {"value": 0.0389270169262729, "mean": 0.2208651854849433, "std": 0.2613920463153887, "bin": {}}, "signature_idxs": {"edge": [1747], "full": [1747]}}, "Myoclonic epilepsy of lafora": {"direction": "up", "overlap": {"value": 0, "mean": 0.5064935064935064, "std": 0.5904736514652601, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 0}}, "setsize": {"value": 1, "mean": 1.651948051948052, "std": 0.4763525894851335, "bin": {"bin_50": 5, "bin_100": 5, "bin_250": 5, "bin_500": 5}}, "score": {"value": 2.064167871955112, "mean": 0.7509794296835115, "std": 1.2007530883412938, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.0}}, "pval": {"value": 0.0390018025527054, "mean": 0.4461372903741615, "std": 0.3353621223644697, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 1.0}}, "signature_idxs": {"edge": [], "full": [1402]}}, "Activation of irf3 irf7 mediated by tbk1 ikk epsilon": {"direction": "up", "overlap": {"value": 1, "mean": 0.9922279792746114, "std": 0.657709725289566, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 2, "bin_500": 2}}, "setsize": {"value": 3, "mean": 1.823834196891192, "std": 0.6675698822137371, "bin": {"bin_50": 11, "bin_100": 11, "bin_250": 11, "bin_500": 11}}, "score": {"value": 2.0591518524785064, "mean": -0.4505739157969205, "std": 1.3710537417328443, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 8.978319783197833, "bin_500": 4.340949820788531}}, "pval": {"value": 0.039479693864961, "mean": 0.4446326469355092, "std": 0.3422491158421791, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0280420066437826, "bin_500": 0.0978216105640502}}, "signature_idxs": {"edge": [116], "full": [116, 136, 1314]}}, "Termination of translesion dna synthesis": {"direction": "up", "overlap": {"value": 10, "mean": 5.929611650485437, "std": 3.658663988299792, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 5}}, "setsize": {"value": 19, "mean": 17.92718446601942, "std": 1.9307272222530525, "bin": {"bin_50": 34, "bin_100": 34, "bin_250": 34, "bin_500": 34}}, "score": {"value": 2.0557967211280346, "mean": -0.1741427519298506, "std": 0.873922017186718, "bin": {"bin_50": 6.38510101010101, "bin_100": 3.111935683364255, "bin_250": 1.216415163783585, "bin_500": 3.3814786318808143}}, "pval": {"value": 0.0398021142193887, "mean": 0.5705397890811215, "std": 0.308389049523953, "bin": {"bin_50": 0.151306852499084, "bin_100": 0.2827159209662828, "bin_250": 0.5676800659750835, "bin_500": 0.0234894970885714}}, "signature_idxs": {"edge": [607, 369, 252, 729, 329, 21, 292, 591, 828, 805], "full": [252, 1242, 591, 729, 21, 329, 369, 2043, 292, 1496, 805, 2419, 607, 827, 828, 990, 2015, 2305, 2790]}}, "Cargo recognition for clathrin mediated endocytosis": {"direction": "up", "overlap": {"value": 12, "mean": 8.473300970873787, "std": 4.054455271697202, "bin": {"bin_50": 1, "bin_100": 2, "bin_250": 3, "bin_500": 5}}, "setsize": {"value": 32, "mean": 32.9126213592233, "std": 4.1286514785567014, "bin": {"bin_50": 78, "bin_100": 78, "bin_250": 78, "bin_500": 78}}, "score": {"value": 2.0556443809714366, "mean": 0.0802035091430913, "std": 1.088296749159732, "bin": {"bin_50": 2.7245670995670994, "bin_100": 2.718665219750407, "bin_250": 1.6119183673469388, "bin_500": 1.337214148767679}}, "pval": {"value": 0.0398168066296451, "mean": 0.5538966462673686, "std": 0.3439390512580828, "bin": {"bin_50": 0.314211533829163, "bin_100": 0.1751944604904992, "bin_250": 0.2950347285537182, "bin_500": 0.3328829292245179}}, "signature_idxs": {"edge": [0, 587, 443, 75, 551, 107, 766, 762, 505, 295, 675, 548], "full": [2454, 2635, 2572, 2575, 1558, 2517, 1806, 587, 3166, 1493, 0, 1738, 295, 675, 745, 1266, 2052, 1824, 906, 987, 762, 766, 2000, 1206, 548, 107, 551, 1770, 75, 1781, 443, 505]}}, "Vesicle mediated transport": {"direction": "up", "overlap": {"value": 88, "mean": 58.50242718446602, "std": 21.341137946840067, "bin": {"bin_50": 3, "bin_100": 7, "bin_250": 21, "bin_500": 42}}, "setsize": {"value": 240, "mean": 249.35679611650485, "std": 25.302660695642658, "bin": {"bin_50": 546, "bin_100": 546, "bin_250": 546, "bin_500": 546}}, "score": {"value": 2.051416128700443, "mean": 0.124174647312522, "std": 0.8268707622329793, "bin": {"bin_50": 1.1534950756665865, "bin_100": 1.3492377188029363, "bin_250": 1.660440528634361, "bin_500": 1.6801900584795322}}, "pval": {"value": 0.0402264396972587, "mean": 0.774755156304532, "std": 0.3241332030593034, "bin": {"bin_50": 0.4922092415470767, "bin_100": 0.2794795873997906, "bin_250": 0.0251360321627063, "bin_500": 0.0022065466408499}}, "signature_idxs": {"edge": [0, 539, 6, 551, 8, 518, 51, 55, 75, 608, 85, 578, 111, 107, 585, 599, 143, 587, 127, 160, 677, 194, 657, 191, 647, 646, 675, 169, 766, 762, 201, 202, 756, 234, 786, 236, 241, 217, 268, 270, 745, 734, 840, 302, 283, 284, 295, 296, 787, 352, 790, 789, 819, 822, 812, 385, 929, 390, 933, 942, 911, 437, 441, 442, 443, 870, 874, 900, 906, 904, 401, 415, 896, 993, 504, 1021, 505, 987, 962, 475, 474, 963, 956, 955, 473, 467, 465, 548], "full": [870, 2745, 283, 2184, 787, 2107, 3121, 2398, 1090, 955, 284, 2454, 956, 789, 1717, 790, 1632, 2887, 217, 169, 1229, 1549, 646, 2989, 647, 1871, 1327, 1872, 127, 2258, 874, 2635, 1639, 2990, 1641, 962, 963, 578, 2572, 2575, 401, 1237, 3153, 1558, 2517, 657, 2333, 1806, 201, 2470, 2335, 585, 1648, 1244, 1960, 587, 3199, 3166, 970, 2901, 518, 2700, 1493, 1251, 85, 1568, 1178, 734, 0, 1342, 1811, 8, 465, 1044, 1413, 1112, 2808, 599, 1415, 1260, 1261, 1815, 1738, 295, 1817, 296, 896, 1740, 1574, 675, 1346, 1500, 1966, 1187, 202, 1049, 677, 467, 1501, 1120, 2134, 1502, 1577, 812, 1121, 745, 900, 1122, 1579, 415, 819, 1266, 904, 2052, 2348, 2135, 302, 473, 1823, 474, 1824, 2269, 2352, 3155, 1269, 2966, 475, 234, 1975, 1899, 1746, 3027, 1271, 1668, 822, 2759, 906, 55, 2589, 987, 608, 2531, 236, 1431, 1676, 911, 1749, 1677, 1831, 1903, 1981, 1278, 1593, 756, 1195, 1280, 1433, 1061, 539, 993, 1985, 762, 1136, 160, 3191, 1601, 2229, 1913, 840, 1442, 385, 2290, 1849, 1445, 3106, 268, 1996, 1289, 929, 1371, 766, 1292, 2000, 1206, 270, 2609, 191, 2003, 548, 933, 1929, 241, 107, 1856, 551, 143, 1766, 1703, 1211, 3038, 390, 2090, 51, 1859, 1860, 1616, 1770, 2387, 1535, 437, 6, 1777, 111, 75, 942, 1863, 1311, 1781, 441, 2023, 194, 442, 2984, 2025, 352, 2953, 443, 2741, 1625, 1387, 1715, 786, 1320, 2987, 504, 1021, 1716, 1322, 505, 1390]}}, "Egfr downregulation": {"direction": "up", "overlap": {"value": 3, "mean": 2.844660194174758, "std": 1.853924106663988, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 2, "bin_500": 2}}, "setsize": {"value": 6, "mean": 7.349514563106796, "std": 1.6082840029839056, "bin": {"bin_50": 22, "bin_100": 22, "bin_250": 22, "bin_500": 22}}, "score": {"value": 2.048421332785736, "mean": -0.0964337885581376, "std": 0.8351362965604756, "bin": {"bin_50": 10.04563492063492, "bin_100": 4.896015549076774, "bin_250": 4.035772357723578, "bin_500": 1.9512096774193548}}, "pval": {"value": 0.0405187330144183, "mean": 0.5725736728819169, "std": 0.294878199386536, "bin": {"bin_50": 0.1006582454154426, "bin_100": 0.1933613304033528, "bin_250": 0.0990342687178565, "bin_500": 0.2922703109028879}}, "signature_idxs": {"edge": [0, 505, 107], "full": [587, 0, 1661, 1266, 107, 505]}}, "Rhobtb gtpase cycle": {"direction": "dw", "overlap": {"value": 7, "mean": 8.859223300970873, "std": 3.879819255453924, "bin": {}}, "setsize": {"value": 31, "mean": 28.87378640776699, "std": 1.4692948685301523, "bin": {}}, "score": {"value": -2.0483700670903016, "mean": 0.0244963620421633, "std": 0.7472097297483927, "bin": {}}, "pval": {"value": 0.0405237522015742, "mean": 0.6760155465171244, "std": 0.3008902581889185, "bin": {}}, "signature_idxs": {"edge": [2870, 2917, 2910, 3212, 3094, 3193, 3124], "full": [1027, 2257, 1237, 3124, 878, 2690, 2121, 3193, 733, 745, 3094, 530, 1667, 906, 1827, 1191, 2532, 3212, 1063, 991, 1199, 2910, 1068, 1606, 2870, 2161, 2917, 775, 551, 1308, 2025]}}, "Tp53 regulates metabolic genes": {"direction": "dw", "overlap": {"value": 14, "mean": 9.567961165048544, "std": 4.509186170565808, "bin": {}}, "setsize": {"value": 35, "mean": 35.47572815533981, "std": 3.1224046626849615, "bin": {}}, "score": {"value": -2.044359087606833, "mean": 0.101655991626129, "std": 0.8223942836099251, "bin": {}}, "pval": {"value": 0.040918085916533, "mean": 0.675386172281155, "std": 0.3288916000544298, "bin": {}}, "signature_idxs": {"edge": [3058, 2927, 3105, 2898, 2748, 2525, 2710, 2700, 2348, 2955, 3022, 2342, 2808, 2332], "full": [2927, 1167, 1555, 2748, 716, 1235, 3022, 1236, 2332, 881, 2898, 2122, 1562, 970, 1406, 2700, 368, 2342, 2525, 2808, 1500, 1966, 1122, 1579, 2348, 1269, 1429, 916, 2710, 3105, 2164, 1381, 496, 2955, 3058]}}, "G1 s specific transcription": {"direction": "up", "overlap": {"value": 6, "mean": 2.5509708737864076, "std": 1.8824235641533549, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 0, "bin_500": 1}}, "setsize": {"value": 8, "mean": 10.196601941747574, "std": 1.373355364810755, "bin": {"bin_50": 29, "bin_100": 29, "bin_250": 29, "bin_500": 29}}, "score": {"value": 2.042982381026895, "mean": 0.5500386685258407, "std": 0.8859821752763714, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 0.0, "bin_500": 0.694883587237712}}, "pval": {"value": 0.0410541822885588, "mean": 0.4863464308926273, "std": 0.3128546874322141, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 1.0, "bin_500": 0.7664238447790522}}, "signature_idxs": {"edge": [511, 519, 653, 252, 821, 876], "full": [653, 876, 511, 1482, 252, 519, 821, 909]}}, "Glutamate neurotransmitter release cycle": {"direction": "dw", "overlap": {"value": 3, "mean": 1.366504854368932, "std": 0.9238713489409176, "bin": {}}, "setsize": {"value": 4, "mean": 2.9684466019417477, "std": 0.7250540753607216, "bin": {}}, "score": {"value": -2.0419480888505968, "mean": -0.2110058354359155, "std": 1.0131207801753597, "bin": {}}, "pval": {"value": 0.0411566809003378, "mean": 0.5458074204631114, "std": 0.3213400368381956, "bin": {}}, "signature_idxs": {"edge": [3021, 3171, 2748], "full": [3021, 2748, 1648, 3171]}}, "Complement cascade": {"direction": "dw", "overlap": {"value": 1, "mean": 0.6435643564356436, "std": 0.5599532939476324, "bin": {}}, "setsize": {"value": 2, "mean": 1.25, "std": 0.4330127018922193, "bin": {}}, "score": {"value": -2.036605133308228, "mean": -0.292855700651673, "std": 1.7218394366077725, "bin": {}}, "pval": {"value": 0.041689627967131, "mean": 0.3059721478775144, "std": 0.3121405184572855, "bin": {}}, "signature_idxs": {"edge": [3153], "full": [3153, 1004]}}, "Regulation of cholesterol biosynthesis by srebp srebf": {"direction": "dw", "overlap": {"value": 8, "mean": 5.412621359223301, "std": 2.758857918047062, "bin": {}}, "setsize": {"value": 23, "mean": 24.3495145631068, "std": 2.7499646524262342, "bin": {}}, "score": {"value": -2.035896187508748, "mean": -0.3976371188459509, "std": 1.159055262486111, "bin": {}}, "pval": {"value": 0.0417607807484303, "mean": 0.413800039800232, "std": 0.3071668375543401, "bin": {}}, "signature_idxs": {"edge": [3057, 2793, 2936, 3076, 2746, 2815, 2754, 2658], "full": [2746, 3076, 2793, 874, 963, 578, 404, 2754, 2936, 1497, 1346, 983, 1267, 1505, 2658, 1588, 1058, 829, 1433, 1679, 2815, 1202, 3057]}}, "Regulation of tnfr1 signaling": {"direction": "up", "overlap": {"value": 3, "mean": 1.8519417475728157, "std": 1.5547987465385102, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 2, "bin_500": 3}}, "setsize": {"value": 6, "mean": 5.308252427184466, "std": 2.243573314566278, "bin": {"bin_50": 31, "bin_100": 31, "bin_250": 31, "bin_500": 31}}, "score": {"value": 2.03320664378006, "mean": -0.1481549369001089, "std": 1.0080178191740088, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 2.7807681525091112, "bin_500": 2.093073593073593}}, "pval": {"value": 0.0420316501259065, "mean": 0.5006984721896415, "std": 0.2991677663727714, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1735315682069146, "bin_500": 0.1913237113672655}}, "signature_idxs": {"edge": [184, 190, 301], "full": [1225, 301, 1747, 535, 184, 190]}}, "Atf6 atf6 alpha activates chaperones": {"direction": "dw", "overlap": {"value": 2, "mean": 1.3422330097087378, "std": 0.5968061141941203, "bin": {}}, "setsize": {"value": 2, "mean": 2.016990291262136, "std": 0.1292347525434382, "bin": {}}, "score": {"value": -2.033012556566391, "mean": -0.5825450739467622, "std": 1.0487140609744774, "bin": {}}, "pval": {"value": 0.0420512544261462, "mean": 0.548532229981257, "std": 0.3265898780558095, "bin": {}}, "signature_idxs": {"edge": [2901, 2470], "full": [2470, 2901]}}, "Scavenging by class a receptors": {"direction": "dw", "overlap": {"value": 2, "mean": 1.25, "std": 0.9100970822000948, "bin": {}}, "setsize": {"value": 2, "mean": 2.9514563106796117, "std": 0.6134201552983035, "bin": {}}, "score": {"value": -2.033012556566391, "mean": -0.3034202338319282, "std": 1.081829275337707, "bin": {}}, "pval": {"value": 0.0420512544261462, "mean": 0.4956832774669065, "std": 0.320402155332595, "bin": {}}, "signature_idxs": {"edge": [2901, 2470], "full": [2470, 2901]}}, "Atf6 atf6 alpha activates chaperone genes": {"direction": "dw", "overlap": {"value": 2, "mean": 1.3422330097087378, "std": 0.5968061141941203, "bin": {}}, "setsize": {"value": 2, "mean": 2.016990291262136, "std": 0.1292347525434382, "bin": {}}, "score": {"value": -2.033012556566391, "mean": -0.5825450739467622, "std": 1.0487140609744774, "bin": {}}, "pval": {"value": 0.0420512544261462, "mean": 0.548532229981257, "std": 0.3265898780558095, "bin": {}}, "signature_idxs": {"edge": [2901, 2470], "full": [2470, 2901]}}, "Methylation": {"direction": "up", "overlap": {"value": 5, "mean": 2.325242718446602, "std": 1.8943051315400636, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 3}}, "setsize": {"value": 9, "mean": 7.114077669902913, "std": 1.1100143766174757, "bin": {"bin_50": 12, "bin_100": 12, "bin_250": 12, "bin_500": 12}}, "score": {"value": 2.0318621678958317, "mean": 0.1097524834644107, "std": 0.8767823341751322, "bin": {"bin_50": 19.196969696969692, "bin_100": 9.356215213358071, "bin_250": 3.6573426573426575, "bin_500": 6.524579124579125}}, "pval": {"value": 0.0421676114368176, "mean": 0.5591141429107, "std": 0.2958252069580291, "bin": {"bin_50": 0.0561990347849709, "bin_100": 0.1105474823156849, "bin_250": 0.2559514735144251, "bin_500": 0.0183139901045195}}, "signature_idxs": {"edge": [277, 446, 41, 710, 588], "full": [2039, 588, 666, 41, 1297, 2013, 710, 277, 446]}}, "Vitamin c ascorbate metabolism": {"direction": "up", "overlap": {"value": 0, "mean": 1.016990291262136, "std": 0.8018199383265381, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 2, "mean": 2.5800970873786406, "std": 0.4935427606534801, "bin": {"bin_50": 6, "bin_100": 6, "bin_250": 6, "bin_500": 6}}, "score": {"value": 2.028861036574743, "mean": 0.0622366900129945, "std": 1.0702757806612992, "bin": {"bin_50": 42.25833333333333, "bin_100": 20.59591836734694, "bin_250": 8.051012145748988, "bin_500": 3.900603621730382}}, "pval": {"value": 0.0424724463326209, "mean": 0.5553456924207798, "std": 0.3295304334099138, "bin": {"bin_50": 0.028497516818446, "bin_100": 0.0568757538574934, "bin_250": 0.1373795195898598, "bin_500": 0.2595746201812825}}, "signature_idxs": {"edge": [], "full": [2331, 41]}}, "Activation of ras in b cells": {"direction": "dw", "overlap": {"value": 1, "mean": 0.8387096774193549, "std": 0.3677985242255284, "bin": {}}, "setsize": {"value": 1, "mean": 1.0, "std": 0.0, "bin": {}}, "score": {"value": -2.0225276588896035, "mean": -0.9799838106972094, "std": 1.5772368931129443, "bin": {}}, "pval": {"value": 0.0431218691605108, "mean": 0.2941750314368556, "std": 0.285592433428993, "bin": {}}, "signature_idxs": {"edge": [1726], "full": [1726]}}, "Endosomal sorting complex required for transport escrt": {"direction": "up", "overlap": {"value": 3, "mean": 4.351941747572815, "std": 2.7903998245901382, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 4}}, "setsize": {"value": 8, "mean": 10.570388349514564, "std": 2.52028601487162, "bin": {"bin_50": 30, "bin_100": 30, "bin_250": 30, "bin_500": 30}}, "score": {"value": 2.0210323182998544, "mean": -0.0957602001200055, "std": 0.98051093227169, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 1.3847549909255898, "bin_500": 3.0121457489878543}}, "pval": {"value": 0.0432764196835724, "mean": 0.5322106115127874, "std": 0.3223117902032849, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.5227832512917782, "bin_500": 0.0564014374232863}}, "signature_idxs": {"edge": [268, 241, 352], "full": [1601, 268, 2609, 241, 1856, 437, 352, 1625]}}, "Role of lat2 ntal lab on calcium mobilization": {"direction": "up", "overlap": {"value": 0, "mean": 0.6577669902912622, "std": 0.7083845042776207, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 2, "mean": 1.7912621359223302, "std": 0.8273958205756888, "bin": {"bin_50": 12, "bin_100": 12, "bin_250": 12, "bin_500": 12}}, "score": {"value": 2.02015848551318, "mean": 0.56181869895938, "std": 1.3026238070481126, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 3.6573426573426575, "bin_500": 1.7719041521858423}}, "pval": {"value": 0.0433669509153866, "mean": 0.4333224703381168, "std": 0.3344681052148984, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.2559514735144251, "bin_500": 0.451869757084416}}, "signature_idxs": {"edge": [], "full": [219, 1266]}}, "Class b 2 secretin family receptors": {"direction": "dw", "overlap": {"value": 2, "mean": 1.1092233009708738, "std": 0.8448659218271451, "bin": {}}, "setsize": {"value": 4, "mean": 2.533980582524272, "std": 0.971092208439994, "bin": {}}, "score": {"value": -2.020075562745786, "mean": 0.0597326810730694, "std": 1.1366900942764722, "bin": {}}, "pval": {"value": 0.0433755502249262, "mean": 0.5149590063070746, "std": 0.3311365573447158, "bin": {}}, "signature_idxs": {"edge": [3153, 2956], "full": [3153, 1822, 1504, 2956]}}, "Translation": {"direction": "up", "overlap": {"value": 92, "mean": 77.70388349514563, "std": 26.784191186963714, "bin": {"bin_50": 4, "bin_100": 6, "bin_250": 16, "bin_500": 40}}, "setsize": {"value": 226, "mean": 217.4393203883495, "std": 8.704909201038353, "bin": {"bin_50": 289, "bin_100": 289, "bin_250": 289, "bin_500": 289}}, "score": {"value": 2.0198731009512234, "mean": -0.6292433087136844, "std": 1.1001288839819463, "bin": {"bin_50": 3.075867446393762, "bin_100": 2.2373190470762565, "bin_250": 2.4441076165214097, "bin_500": 3.3142175689658195}}, "pval": {"value": 0.0433965520995569, "mean": 0.5403058846506507, "std": 0.3388062297179274, "bin": {"bin_50": 0.0494662102872503, "bin_100": 0.061949520967179, "bin_250": 0.0018537288836564, "bin_500": 1.891442716634794e-09}}, "signature_idxs": {"edge": [565, 22, 513, 29, 27, 529, 525, 524, 48, 604, 636, 605, 86, 581, 84, 602, 104, 598, 601, 681, 680, 695, 133, 149, 150, 679, 153, 154, 180, 656, 172, 670, 196, 751, 750, 728, 226, 725, 721, 277, 741, 836, 866, 300, 299, 293, 803, 799, 349, 818, 825, 328, 817, 815, 336, 813, 816, 379, 395, 359, 367, 940, 886, 873, 446, 905, 903, 902, 405, 901, 899, 897, 894, 418, 416, 412, 988, 954, 450, 969, 456, 457, 957, 968, 468, 471, 469, 982, 470, 981, 464, 974], "full": [954, 3020, 1393, 957, 196, 1636, 2188, 1947, 2115, 1330, 450, 873, 2465, 2407, 1952, 581, 3091, 84, 359, 1481, 2410, 721, 656, 1803, 27, 1559, 725, 328, 1101, 149, 405, 2412, 1038, 456, 1561, 886, 513, 968, 172, 1247, 457, 728, 969, 367, 799, 1491, 1042, 973, 1494, 1255, 1180, 2806, 1409, 2127, 1654, 670, 598, 1182, 86, 2343, 2473, 1110, 974, 894, 226, 464, 803, 293, 2701, 1410, 150, 1571, 2648, 2129, 1735, 1111, 1046, 2998, 524, 525, 412, 2266, 2477, 3207, 897, 1262, 741, 1891, 1048, 1968, 1119, 2653, 1264, 468, 2050, 981, 899, 1189, 813, 1578, 3093, 469, 104, 982, 601, 470, 901, 471, 815, 816, 679, 902, 299, 1350, 817, 818, 416, 1123, 180, 48, 903, 602, 1420, 680, 681, 300, 1124, 133, 604, 605, 2810, 529, 2938, 1423, 2053, 1664, 2210, 2655, 3066, 1581, 1582, 379, 1050, 153, 1666, 905, 1268, 22, 1128, 1428, 1587, 154, 750, 751, 1590, 988, 418, 825, 2062, 2536, 1594, 336, 3007, 2224, 3080, 1360, 2541, 1362, 836, 3181, 2289, 2864, 2666, 1443, 3011, 2371, 2155, 695, 1074, 2721, 2001, 1373, 1924, 2828, 2502, 1301, 2010, 2166, 2381, 2087, 29, 1705, 2167, 1460, 2092, 1932, 1708, 2445, 1463, 349, 2016, 940, 2507, 2174, 2952, 2619, 1779, 1384, 1468, 395, 636, 1864, 277, 1086, 866, 1714, 2106, 2742, 1223, 1786, 1942, 1542, 1543, 565, 2321, 446]}}, "Slc mediated transmembrane transport": {"direction": "dw", "overlap": {"value": 13, "mean": 8.672330097087379, "std": 4.348519601656105, "bin": {}}, "setsize": {"value": 20, "mean": 21.910194174757283, "std": 3.146764860695784, "bin": {}}, "score": {"value": -2.019730369783104, "mean": 1.4735742044813558, "std": 1.3934177975338422, "bin": {}}, "pval": {"value": 0.0434113631276187, "mean": 0.239038892478899, "std": 0.3068823132077037, "bin": {}}, "signature_idxs": {"edge": [2498, 3171, 2430, 2804, 2408, 2133, 2605, 2392, 2302, 2267, 2862, 2834, 2334], "full": [2408, 1957, 1881, 2334, 891, 2804, 1253, 1254, 2267, 2133, 1906, 2430, 2862, 2498, 2605, 3171, 2834, 2302, 2392, 566]}}, "Cytosolic sulfonation of small molecules": {"direction": "up", "overlap": {"value": 3, "mean": 1.4174757281553398, "std": 1.1618889194158637, "bin": {"bin_50": 0, "bin_100": 1, "bin_250": 3, "bin_500": 4}}, "setsize": {"value": 5, "mean": 4.563106796116505, "std": 0.9771158561611718, "bin": {"bin_50": 14, "bin_100": 14, "bin_250": 14, "bin_500": 14}}, "score": {"value": 2.016225520007102, "mean": 0.2618118421521333, "std": 0.947384439548352, "bin": {"bin_50": 0.0, "bin_100": 7.915227629513343, "bin_250": 11.061595547309834, "bin_500": 7.844534412955466}}, "pval": {"value": 0.0437763990132022, "mean": 0.5085407170975286, "std": 0.2939581688170716, "bin": {"bin_50": 1.0, "bin_100": 0.1277572387780678, "bin_250": 0.0042425564235442, "bin_500": 0.0038035060050311}}, "signature_idxs": {"edge": [128, 74, 171], "full": [249, 128, 171, 2605, 74]}}, "Resolution of abasic sites ap sites": {"direction": "up", "overlap": {"value": 13, "mean": 9.1747572815534, "std": 4.762672792199121, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 3, "bin_500": 7}}, "setsize": {"value": 30, "mean": 25.439320388349515, "std": 3.13122506567548, "bin": {"bin_50": 41, "bin_100": 41, "bin_250": 41, "bin_500": 41}}, "score": {"value": 2.0160120696643897, "mean": -0.3343642244554319, "std": 1.09323398501863, "bin": {"bin_50": 5.2640625, "bin_100": 2.565561224489796, "bin_250": 3.1933404940923737, "bin_500": 4.052234335689469}}, "pval": {"value": 0.043798713706963, "mean": 0.4940880125362986, "std": 0.3344700719821075, "bin": {"bin_50": 0.1795501084992132, "bin_100": 0.3302382631712943, "bin_250": 0.0771340965144245, "bin_500": 0.0033654671202252}}, "signature_idxs": {"edge": [607, 369, 560, 130, 252, 329, 729, 698, 21, 173, 724, 292, 591], "full": [1099, 252, 724, 1242, 1104, 1039, 591, 173, 729, 2337, 21, 329, 369, 2043, 130, 292, 1496, 805, 1813, 2419, 3000, 607, 990, 1602, 698, 2015, 2305, 560, 1016, 2790]}}, "Calcineurin activates nfat": {"direction": "up", "overlap": {"value": 0, "mean": 0.4685714285714286, "std": 0.6350574455777, "bin": {"bin_50": 1, "bin_100": 1, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 2, "mean": 1.542857142857143, "std": 0.4981598792617911, "bin": {"bin_50": 8, "bin_100": 8, "bin_250": 8, "bin_500": 8}}, "score": {"value": 2.013169171565629, "mean": 0.7917900635445944, "std": 1.5752808291471605, "bin": {"bin_50": 30.178571428571427, "bin_100": 14.708454810495628, "bin_250": 5.749566223250434, "bin_500": 2.785570566254671}}, "pval": {"value": 0.0440968352485882, "mean": 0.3360161953597127, "std": 0.3302064236118249, "bin": {"bin_50": 0.0378187125466048, "bin_100": 0.075113296023457, "bin_250": 0.1788587842302525, "bin_500": 0.3301808657155594}}, "signature_idxs": {"edge": [], "full": [31, 748]}}, "Rora activates gene expression": {"direction": "dw", "overlap": {"value": 1, "mean": 1.046116504854369, "std": 0.8978450284790148, "bin": {}}, "setsize": {"value": 3, "mean": 3.029126213592233, "std": 0.9599384150919048, "bin": {}}, "score": {"value": -2.010441553604894, "mean": 0.2617161275186323, "std": 0.9732556058059804, "bin": {}}, "pval": {"value": 0.0443844762411675, "mean": 0.5709152717699069, "std": 0.3214947385734508, "bin": {}}, "signature_idxs": {"edge": [3201], "full": [3201, 1679, 1202]}}, "Inhibition of dna recombination at telomere": {"direction": "dw", "overlap": {"value": 6, "mean": 4.905339805825243, "std": 2.359296964369979, "bin": {}}, "setsize": {"value": 12, "mean": 11.024271844660197, "std": 1.7007688734957307, "bin": {}}, "score": {"value": -2.0095472572943627, "mean": -0.8916718361953078, "std": 0.8319258788149869, "bin": {}}, "pval": {"value": 0.044479128255326, "mean": 0.3869484380299055, "std": 0.3007151998846098, "bin": {}}, "signature_idxs": {"edge": [2475, 2338, 2698, 2641, 3190, 2904], "full": [1474, 2038, 2641, 2698, 2338, 2475, 1663, 1351, 2904, 3190, 1467, 946]}}, "Rna polymerase i transcription termination": {"direction": "dw", "overlap": {"value": 5, "mean": 4.912621359223301, "std": 2.435006812520144, "bin": {}}, "setsize": {"value": 11, "mean": 10.975728155339803, "std": 1.8286801447304963, "bin": {}}, "score": {"value": -2.007667888364564, "mean": -0.6290096027967242, "std": 0.7230108434003878, "bin": {}}, "pval": {"value": 0.0446785951392048, "mean": 0.5173277288264982, "std": 0.303345160618811, "bin": {}}, "signature_idxs": {"edge": [2991, 2641, 2839, 2904, 3198], "full": [3198, 1634, 2991, 2123, 1103, 2641, 1404, 2904, 618, 2300, 2839]}}, "Recycling pathway of l1": {"direction": "up", "overlap": {"value": 7, "mean": 6.898058252427185, "std": 4.33088884310876, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 4, "bin_500": 6}}, "setsize": {"value": 20, "mean": 21.32281553398058, "std": 1.666390738148133, "bin": {"bin_50": 41, "bin_100": 41, "bin_250": 41, "bin_500": 41}}, "score": {"value": 2.0074042238862546, "mean": -0.3135781567418741, "std": 0.965013432779371, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 4.391227292866637, "bin_500": 3.366898954703833}}, "pval": {"value": 0.0447066394426935, "mean": 0.5490472935437266, "std": 0.3357087870369806, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0170966332614883, "bin_500": 0.0138285747900004}}, "signature_idxs": {"edge": [143, 516, 302, 401, 158, 201, 236], "full": [2635, 1641, 2572, 401, 1558, 201, 1037, 1105, 516, 1408, 1415, 675, 2052, 302, 1824, 236, 2278, 158, 2000, 143]}}, "Downregulation of erbb4 signaling": {"direction": "up", "overlap": {"value": 1, "mean": 0.4772117962466488, "std": 0.6236111652602575, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 1, "bin_500": 1}}, "setsize": {"value": 2, "mean": 1.584450402144772, "std": 0.6395998504687735, "bin": {"bin_50": 7, "bin_100": 7, "bin_250": 7, "bin_500": 7}}, "score": {"value": 2.0044488454664995, "mean": 0.8023821427007874, "std": 1.370234814062003, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 6.708502024291498, "bin_500": 3.250167672702884}}, "pval": {"value": 0.0450220014154612, "mean": 0.3552479696410924, "std": 0.3210551766816724, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.1583736196074974, "bin_500": 0.295760276625992}}, "signature_idxs": {"edge": [201], "full": [201, 770]}}, "Defective intrinsic pathway for apoptosis": {"direction": "dw", "overlap": {"value": 5, "mean": 4.87378640776699, "std": 2.4001602359554775, "bin": {}}, "setsize": {"value": 15, "mean": 14.33252427184466, "std": 1.8111334317667775, "bin": {}}, "score": {"value": -1.9955066999613835, "mean": -0.5695700126738176, "std": 0.8487476667207384, "bin": {}}, "pval": {"value": 0.0459876441495574, "mean": 0.4808297871005385, "std": 0.2841082153163492, "bin": {}}, "signature_idxs": {"edge": [3123, 2960, 3213, 3026, 3022], "full": [1634, 2960, 3123, 2406, 3022, 1956, 406, 3213, 2697, 368, 802, 1579, 531, 3026, 234]}}, "Hdms demethylate histones": {"direction": "dw", "overlap": {"value": 6, "mean": 2.5679611650485437, "std": 1.9602215840781936, "bin": {}}, "setsize": {"value": 9, "mean": 7.419902912621359, "std": 1.6178290590666398, "bin": {}}, "score": {"value": -1.991296811246252, "mean": -0.1915264052286758, "std": 1.0613180099446118, "bin": {}}, "pval": {"value": 0.0464482658301168, "mean": 0.4582893386446365, "std": 0.3001188936221742, "bin": {}}, "signature_idxs": {"edge": [2325, 3145, 2450, 2645, 2888, 2986], "full": [2888, 2325, 2645, 1351, 1135, 1689, 3145, 2450, 2986]}}, "Toll like receptor tlr1 tlr2 cascade": {"direction": "up", "overlap": {"value": 6, "mean": 5.737864077669903, "std": 3.694554284371242, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 2, "bin_500": 5}}, "setsize": {"value": 16, "mean": 19.259708737864077, "std": 3.1411808911450043, "bin": {"bin_50": 70, "bin_100": 70, "bin_250": 70, "bin_500": 70}}, "score": {"value": 1.9900186020136232, "mean": -0.3090930516509614, "std": 0.8713165071805932, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 1.181252989000478, "bin_500": 1.5030425963488845}}, "pval": {"value": 0.0465888863813666, "mean": 0.5618450816217857, "std": 0.3020076906573227, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.5109892685584014, "bin_500": 0.2561486974132024}}, "signature_idxs": {"edge": [516, 181, 103, 251, 256, 304], "full": [1225, 251, 516, 665, 1566, 256, 103, 181, 304, 1131, 1057, 1592, 2278, 1196, 2488, 2084]}}, "Rna polymerase i promoter escape": {"direction": "dw", "overlap": {"value": 5, "mean": 5.643203883495145, "std": 2.6806348739363144, "bin": {}}, "setsize": {"value": 13, "mean": 14.050970873786408, "std": 1.8914277827620305, "bin": {}}, "score": {"value": -1.9804200805419705, "mean": -0.8257104975167466, "std": 0.8078359880984057, "bin": {}}, "pval": {"value": 0.0476563454202869, "mean": 0.4358461129919234, "std": 0.3088764226099317, "bin": {}}, "signature_idxs": {"edge": [2991, 2641, 2839, 2904, 3198], "full": [3198, 1634, 2991, 2123, 1103, 2641, 1404, 1351, 2904, 1353, 618, 2300, 2839]}}, "Regulation of runx1 expression and activity": {"direction": "up", "overlap": {"value": 2, "mean": 1.366504854368932, "std": 1.0470227867605617, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 2, "bin_500": 3}}, "setsize": {"value": 5, "mean": 3.4563106796116503, "std": 0.9656900448391708, "bin": {"bin_50": 17, "bin_100": 17, "bin_250": 17, "bin_500": 17}}, "score": {"value": 1.977127655244008, "mean": 0.102758814976262, "std": 0.9693161946197688, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 5.383739837398374, "bin_500": 4.1922077922077925}}, "pval": {"value": 0.0480272024778967, "mean": 0.5903388253184545, "std": 0.3177504143982604, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0630532374058985, "bin_500": 0.0472723399635447}}, "signature_idxs": {"edge": [116, 201], "full": [201, 1051, 116, 259, 1381]}}, "Arachidonate production from dag": {"direction": "dw", "overlap": {"value": 2, "mean": 0.9344660194174758, "std": 0.4756971953468445, "bin": {}}, "setsize": {"value": 2, "mean": 2.3276699029126213, "std": 0.6550116042602028, "bin": {}}, "score": {"value": -1.9689118192912587, "mean": -0.9651874960920912, "std": 1.541941784830176, "bin": {}}, "pval": {"value": 0.0489632180620795, "mean": 0.2192697266736875, "std": 0.236446283716031, "bin": {}}, "signature_idxs": {"edge": [3178, 2497], "full": [2497, 3178]}}, "Apobec3g mediated resistance to hiv 1 infection": {"direction": "dw", "overlap": {"value": 1, "mean": 1.766990291262136, "std": 0.96243908893277, "bin": {}}, "setsize": {"value": 2, "mean": 2.9563106796116503, "std": 0.2044029443827893, "bin": {}}, "score": {"value": -1.9683213810482143, "mean": -0.7016256613081497, "std": 0.9171130915870188, "bin": {}}, "pval": {"value": 0.0490310713657495, "mean": 0.4537282344975301, "std": 0.2937067499938155, "bin": {}}, "signature_idxs": {"edge": [2958], "full": [1232, 2958]}}, "Ctla4 inhibitory signaling": {"direction": "up", "overlap": {"value": 2, "mean": 2.5, "std": 1.6626975391802674, "bin": {"bin_50": 0, "bin_100": 0, "bin_250": 3, "bin_500": 3}}, "setsize": {"value": 8, "mean": 6.686893203883495, "std": 1.5459069221319763, "bin": {"bin_50": 17, "bin_100": 17, "bin_250": 17, "bin_500": 17}}, "score": {"value": 1.9603507416968005, "mean": 0.2776426982509004, "std": 0.9108905562415662, "bin": {"bin_50": 0.0, "bin_100": 0.0, "bin_250": 8.688629737609329, "bin_500": 4.1922077922077925}}, "pval": {"value": 0.0499548090332999, "mean": 0.5315314558160165, "std": 0.3127539794709458, "bin": {"bin_50": 1.0, "bin_100": 1.0, "bin_250": 0.0075105395483816, "bin_500": 0.0472723399635447}}, "signature_idxs": {"edge": [116, 201], "full": [1238, 219, 201, 665, 1566, 116, 1592, 1062]}}}}