term	overlap	setsize	score	pval
Metabolism of rna	453	647	6.446912697993771	1.064229694129608e-108
Translation	215	289	7.459683305920252	5.678190929484905e-58
Processing of capped intron containing pre mrna	185	239	8.726530235258414	1.8273162596863116e-54
Rrna processing	161	202	9.935668685545917	1.415350462704678e-50
Influenza infection	124	150	11.936380216714944	2.5051926469342027e-42
Mrna splicing	144	188	8.227783452502553	1.518887579711855e-41
Infectious disease	336	619	3.0938098684490614	6.480895505405897e-41
Metabolism of amino acids and derivatives	188	281	5.126578006841226	9.21963286955706e-40
Eukaryotic translation initiation	100	116	15.534232365145227	1.4429487271592327e-37
Regulation of expression of slits and robos	122	155	9.237271671418013	1.7768320906545362e-37
Host interactions of hiv factors	95	116	11.216611601492511	5.164689810178104e-32
Cellular responses to stimuli	313	614	2.679433616202803	3.112927720716078e-31
Srp dependent cotranslational protein targeting to membrane	89	108	11.593542070816037	1.8382682019346372e-30
Signaling by robo receptors	135	197	5.443167319656306	2.0116836363556705e-30
Selenoamino acid metabolism	88	107	11.45933014354067	5.268531171356453e-30
Eukaryotic translation elongation	76	89	14.416904083570753	3.1277659000266676e-28
Cell cycle mitotic	253	498	2.6236701909679536	5.537097295979052e-25
Nonsense mediated decay nmd	84	110	7.974711670722675	1.6152110496327775e-24
Response of eif2ak4 gcn2 to amino acid deficiency	75	94	9.722948956209516	3.729549380008359e-24
Cell cycle	295	613	2.368541332904252	3.9463133261713715e-24
Hiv infection	133	213	4.142584819867087	4.916359227612837e-24
M phase	192	355	2.9620333041191937	3.291770053689053e-23
Synthesis of dna	86	117	6.847656683613436	4.209641139012597e-23
Mitotic metaphase and anaphase	136	225	3.806848582129481	1.2549823646827677e-22
Transport of mature transcript to cytoplasm	65	81	9.976511786812436	2.365331219298456e-21
Neutrophil degranulation	172	319	2.9280744922082307	1.0650210790053376e-20
Rrna modification in the nucleus and cytosol	54	63	14.693669162695713	1.462659609888191e-20
Regulation of mrna stability by proteins that bind au rich elements	63	79	9.66293956981905	1.8183293177163342e-20
Dna replication	92	137	5.046957854406131	3.721356616571508e-20
Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s	50	59	13.5867512652013	1.102321712994336e-18
S phase	97	158	3.923502930434044	3.8886621415691876e-17
Auf1 hnrnp d0 binds and destabilizes mrna	42	48	17.08	5.84838118932419e-17
Innate immune system	277	624	2.016111792209998	1.3819251246343758e-16
Glucose metabolism	59	80	6.880603315311805	2.28698603388923e-16
Cell cycle checkpoints	137	257	2.832772913018097	3.625328457611542e-16
Cross presentation of soluble exogenous antigens endosomes	37	41	22.538071065989847	4.541732290256804e-16
Separation of sister chromatids	104	179	3.4229732225300094	6.671852756516317e-16
Cellular response to starvation	86	139	3.99294887610539	1.2407750460577524e-15
Disorders of transmembrane transporters	75	115	4.604902296880357	1.3213728853472817e-15
Dna replication pre initiation	64	92	5.601873536299766	1.4110273400372873e-15
The citric acid tca cycle and respiratory electron transport	95	160	3.601630333767027	1.797512181906185e-15
Interactions of vpr with host cellular proteins	34	37	27.590038314176244	1.9759882696548863e-15
Interactions of rev with host cellular proteins	34	37	27.590038314176244	1.9759882696548863e-15
Orc1 removal from chromatin	50	65	8.145252662587808	2.450024215665487e-15
G2 m checkpoints	83	134	4.001772726966345	3.560894875755398e-15
Nervous system development	206	443	2.1736197564071107	4.737912354942341e-15
Regulation of hsf1 mediated heat shock response	55	76	6.405386124487248	9.40165407795167e-15
Transport of mature mrnas derived from intronless transcripts	37	43	15.021206993795824	1.4056610720782864e-14
Vesicle mediated transport	242	546	1.997368421052632	1.7019663252395542e-14
Switching of origins to a post replicative state	59	85	5.553541923470324	2.1414801346296366e-14
Apc c mediated degradation of cell cycle proteins	57	81	5.810051107325383	2.2885293511558342e-14
Regulation of hmox1 expression and activity	45	58	8.446529717313565	3.556715559681307e-14
Negative regulation of notch4 signaling	40	49	10.832580548027703	4.275411722228427e-14
Nuclear import of rev protein	31	34	25.1301362152426	6.176658394136101e-14
Membrane trafficking	235	532	1.9822759086451505	6.599964372868741e-14
Dectin 1 mediated noncanonical nf kb signaling	42	53	9.30989214175655	6.861370046788046e-14
Cellular response to heat stress	62	93	4.896245733788396	8.614849640150836e-14
Golgi to er retrograde transport	72	115	4.10633959859828	1.1038761414720465e-13
Metabolism of polyamines	39	48	10.558189411897503	1.2023117670759e-13
The role of gtse1 in g2 m progression after g2 checkpoint	49	67	6.646921131120927	1.4028178190895632e-13
Rhobtb gtpase cycle	30	33	24.311276164753544	1.93474880642678e-13
Defective cftr causes cystic fibrosis	42	54	8.532881355932203	2.212789147108647e-13
Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1	49	68	6.296206878051398	3.595798517442412e-13
Glycolysis	48	66	6.509057971014493	3.542466020172552e-13
Degradation of gli1 by the proteasome	41	53	8.326894837908053	5.933454076952214e-13
Export of viral ribonucleoproteins from nucleus	29	32	23.492968837889528	6.041616598235664e-13
Antiviral mechanism by ifn stimulated genes	51	73	5.66106148187073	8.467968913470063e-13
Scf skp2 mediated degradation of p27 p21	41	54	7.685295727654251	1.766785885616733e-12
Transport of the slbp dependant mature mrna	31	36	15.07389395474502	2.00665419128122e-12
Trna aminoacylation	35	43	10.646770375380454	2.0381492300034824e-12
Stabilization of p53	39	51	7.915340331865899	4.195555782300247e-12
Ns1 mediated effects on host pathways	33	40	11.466277217206583	4.324851868958675e-12
Hedgehog ligand biogenesis	40	53	7.4953095684803	4.62525826924332e-12
Snrnp assembly	40	53	7.4953095684803	4.62525826924332e-12
Dna strand elongation	30	35	14.582714382174206	5.940516248724489e-12
Programmed cell death	96	179	2.844039139985356	6.424567053790581e-12
Viral messenger rna synthesis	35	44	9.46248074249427	7.150341113275715e-12
Cytosolic trna aminoacylation	23	24	55.7995958235096	9.224215550900995e-12
Degradation of axin	37	48	8.187694200892171	9.88820204434666e-12
Degradation of dvl	38	50	7.709772060482961	1.1058604042025506e-11
Rna polymerase ii transcription termination	46	66	5.6086897488119485	1.2870102454487538e-11
Nuclear envelope breakdown	40	54	6.958962446767325	1.2792322222572416e-11
Cdt1 association with the cdc6 orc origin complex	40	54	6.958962446767325	1.2792322222572416e-11
Tnfr2 non canonical nf kb pathway	42	58	6.396101694915254	1.3616712384670835e-11
Signaling by rho gtpases miro gtpases and rhobtb3	248	593	1.7968394811340684	1.7217561276847135e-11
Antigen processing cross presentation	51	77	4.787461093819475	2.0169415727311628e-11
Abc family proteins mediated transport	50	75	4.880353501019714	2.2054152657857274e-11
Er to golgi anterograde transport	74	129	3.2963175275718117	2.477136603983652e-11
Nuclear pore complex npc disassembly	30	36	12.150573936529373	2.560982653564846e-11
Nuclear envelope ne reassembly	48	71	5.090500945179584	2.586045032333897e-11
Regulation of glucokinase by glucokinase regulatory protein	27	31	16.39123102866779	3.250895323724511e-11
Regulation of runx2 expression and activity	43	61	5.821144644135488	3.3277400436116327e-11
Mitotic prophase	58	93	4.049099230694322	3.458723675884624e-11
Sumoylation of dna replication proteins	35	46	7.739877640114367	6.931119142614586e-11
Apoptosis	85	159	2.817290975185712	1.296253651044661e-10
Abc transporter disorders	42	61	5.383942908117752	1.8639567691785918e-10
Mapk6 mapk4 signaling	49	77	4.267074413863405	4.173886490107386e-10
Asymmetric localization of pcp proteins	38	54	5.779113067027759	5.090345485300433e-10
Pyruvate metabolism and citric acid tca cycle	35	48	6.547306261543664	5.165466868183952e-10
Cytokine signaling in immune system	171	392	1.915326390147584	6.611008189988072e-10
Pcp ce pathway	49	78	4.119359790033627	8.044657504760148e-10
Hiv life cycle	77	144	2.8137989298789075	9.45933797084378e-10
Cellular response to hypoxia	40	59	5.124090714591357	1.0453467826105678e-09
Degradation of beta catenin by the destruction complex	48	77	4.033920539730135	1.7478347053470566e-09
Mitotic g1 phase and g1 s transition	76	143	2.7763036668509304	1.7558405945705784e-09
Gene silencing by rna	47	75	4.090128547174388	2.0059610678552344e-09
Trna processing in the nucleus	40	60	4.867208672086721	2.2498747858223754e-09
Postmitotic nuclear pore complex npc reformation	23	27	13.944088918827887	2.5243822813018278e-09
Rhobtb2 gtpase cycle	20	22	24.2328398384926	2.580648642431053e-09
Rhobtb1 gtpase cycle	20	22	24.2328398384926	2.580648642431053e-09
Copi mediated anterograde transport	53	89	3.5906392953007447	2.683060938922656e-09
Mrna decay by 3 to 5 exoribonuclease	16	16	inf	2.9388252152872163e-09
Regulation of runx3 expression and activity	36	52	5.471244925575101	2.977203013814409e-09
Regulation of pten stability and activity	41	63	4.535627368226487	4.216984600766907e-09
G1 s dna damage checkpoints	40	61	4.634791586011098	4.689081341100675e-09
Cellular response to chemical stress	71	133	2.799980121699374	4.666951531451194e-09
Transcriptional regulation by small rnas	38	57	4.8645903859174	5.681591394224917e-09
Deadenylation dependent mrna decay	38	57	4.8645903859174	5.681591394224917e-09
Regulation of ras by gaps	38	57	4.8645903859174	5.681591394224917e-09
Sumoylation of sumoylation proteins	27	35	8.19106239460371	6.517319995450773e-09
Asparagine n linked glycosylation	114	245	2.1386830337013087	6.6956136671909085e-09
Mitochondrial translation	54	93	3.3767083835157354	6.7442544300602546e-09
Cytoprotection by hmox1	61	110	3.0389781296346583	8.376164711457735e-09
Resolution of ap sites via the multiple nucleotide patch replacement pathway	23	28	11.153721791849108	1.019236836998236e-08
Transport to the golgi and subsequent modification	76	148	2.581694863587868	1.3024295312763592e-08
Lagging strand synthesis	20	23	16.152983400628084	1.4290519936281152e-08
Rho gtpase effectors	113	246	2.086728631234216	1.9063461197258242e-08
Fceri mediated nf kb activation	42	68	3.930586701434159	2.6832125055336512e-08
Intra golgi and retrograde golgi to er traffic	88	181	2.3170413815575106	2.8625509933006894e-08
Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins	62	116	2.801794969030464	4.1330064631098064e-08
Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand	32	47	5.181261261261262	4.2622324097204985e-08
Gene and protein expression by jak stat signaling after interleukin 12 stimulation	25	33	7.579204583754635	4.556916739502157e-08
Metabolism of carbohydrates	95	201	2.1958629942490933	4.7398724395304597e-08
Interleukin 12 family signaling	30	43	5.6025035059471255	4.774689658924197e-08
Copi dependent golgi to er retrograde traffic	48	83	3.3395962732919253	5.5171055953579904e-08
Mitotic g2 g2 m phases	89	186	2.2462472167079204	6.151176327170603e-08
Mhc class ii antigen presentation	55	100	2.9791926758218894	6.589894926256305e-08
Hedgehog on state	42	70	3.648813559322034	8.827088305020447e-08
Runx1 regulates transcription of genes involved in differentiation of hscs	41	68	3.693123486075028	1.036084105443266e-07
Post translational protein modification	367	1003	1.4438191075172206	1.1266244917748905e-07
Mitotic telophase cytokinesis	13	13	inf	1.1746243515166019e-07
Interleukin 12 signaling	27	38	5.954652767131688	1.243755652926566e-07
Citric acid cycle tca cycle	18	21	14.527908540685944	1.264510055831989e-07
Protein localization	71	142	2.441971927422116	1.546010124492075e-07
Signaling by notch4	42	71	3.52250146113384	1.551007133438453e-07
Downstream signaling events of b cell receptor bcr	42	71	3.52250146113384	1.551007133438453e-07
Resolution of abasic sites ap sites	28	41	5.225474929928371	2.738157488684437e-07
Hedgehog off state	52	96	2.878169449598021	2.882699343483795e-07
Sumoylation of ubiquitinylation proteins	27	39	5.457672849915683	2.911658097257315e-07
Signaling by alk in cancer	33	52	4.217374290745451	3.3509837492823853e-07
Initiation of nuclear envelope ne reformation	17	20	13.716190476190476	3.721098308991298e-07
Pcna dependent long patch base excision repair	19	24	9.201547258661284	6.159934168181507e-07
Interferon signaling	64	128	2.4385245901639343	6.25902960526667e-07
Uch proteinases	44	79	3.057142857142857	8.410725619955021e-07
Respiratory electron transport	53	101	2.6884711353067936	8.436059939704765e-07
Mitotic prometaphase	90	198	2.037675166551803	9.299114415655672e-07
Sumoylation of rna binding proteins	30	47	4.281884259443142	9.596454889044655e-07
Copi independent golgi to er retrograde traffic	29	45	4.39697941275734	1.0866338369135947e-06
Interleukin 1 signaling	45	82	2.95779491741487	1.1082074174815767e-06
Diseases of signal transduction by growth factor receptors and second messengers	138	333	1.737987170502938	1.143342376792344e-06
Slc transporter disorders	33	54	3.8146574614976094	1.1811792868925703e-06
Resolution of sister chromatid cohesion	60	120	2.43656207366985	1.3923940973182865e-06
Tcr signaling	46	85	2.8686441415565653	1.4312454686222303e-06
Clec7a dectin 1 signaling	46	85	2.8686441415565653	1.4312454686222303e-06
Translocation of slc2a4 glut4 to the plasma membrane	38	66	3.296837218299642	1.547461017805486e-06
Gluconeogenesis	19	25	7.66689090705236	1.8576764020084131e-06
Polymerase switching	14	16	16.928811282740092	2.1808621268983303e-06
Hcmv early events	43	79	2.9032817150823256	2.5583240473278973e-06
Trna processing	55	109	2.479539464558191	2.640264668791787e-06
Metabolism of nucleotides	44	82	2.814611154752553	3.2667890518443834e-06
Transcription coupled nucleotide excision repair tc ner	44	82	2.814611154752553	3.2667890518443834e-06
Unfolded protein response upr	41	75	2.9299140869495885	3.763189930693566e-06
Transcriptional regulation by runx2	51	100	2.5321458062993982	4.058164136505078e-06
Rhoh gtpase cycle	22	32	5.328888888888889	4.517248699676479e-06
Cohesin loading onto chromatin	10	10	inf	4.684855679779537e-06
Extension of telomeres	31	52	3.581045657033499	5.220897739404881e-06
Mrna splicing minor pathway	31	52	3.581045657033499	5.220897739404881e-06
Sumoylation of dna damage response and repair proteins	41	76	2.8458052960255604	5.870725778091185e-06
Developmental biology	246	665	1.450675923495577	6.77548994686373e-06
Telomere maintenance	40	74	2.857484457197513	7.135199690905889e-06
Hcmv late events	35	62	3.146269367101292	7.336716960121349e-06
Cyclin a cdk2 associated events at s phase entry	42	79	2.75780119102153	7.407596807876741e-06
Processive synthesis on the lagging strand	14	17	11.284307141258116	8.995624461165932e-06
Ksrp khsrp binds and destabilizes mrna	14	17	11.284307141258116	8.995624461165932e-06
Sumoylation	71	155	2.060285942518054	9.199641219017778e-06
Activation of the pre replicative complex	22	33	4.843771043771044	9.796100031117376e-06
Mitochondrial calcium ion transport	16	21	7.740860215053764	1.2025055077223563e-05
Cristae formation	19	27	5.748570467541204	1.221398829119576e-05
Rho gtpase cycle	152	387	1.5871860952951753	1.2630859491283837e-05
Signaling by interleukins	104	248	1.7655432440751	1.2855292262731196e-05
Potential therapeutics for sars	37	68	2.897232683805469	1.2794618546924024e-05
Mitotic spindle checkpoint	54	111	2.304575257067106	1.2945045390111307e-05
Ub specific processing proteases	69	151	2.0502574201246637	1.3534460182862492e-05
Apoptotic execution phase	28	47	3.5723417856381845	1.5173153521675294e-05
Advanced glycosylation endproduct receptor signaling	9	9	inf	1.5998868525406347e-05
Fatty acid metabolism	56	117	2.233483718229329	1.656327326720304e-05
Mitochondrial protein import	33	59	3.07892479267944	1.735512707881176e-05
Pten regulation	60	128	2.147500200625953	1.8787551126424803e-05
Sars cov infections	60	128	2.147500200625953	1.8787551126424803e-05
Trans golgi network vesicle budding	37	69	2.8063028764805416	1.9844307123214944e-05
Hcmv infection	50	102	2.337499346336872	2.0643547786486465e-05
C type lectin receptors clrs	49	100	2.3351988433837687	2.522596323351822e-05
Base excision repair	31	55	3.132106270404143	2.529286091767756e-05
Nucleotide biosynthesis	13	16	10.474767819178696	2.5468636737079265e-05
Interleukin 1 family signaling	47	95	2.3792586304470853	2.6777003782820023e-05
Transport of small molecules	147	377	1.5667120042790557	2.71442239890266e-05
Gap filling dna repair synthesis and ligation in gg ner	19	28	5.109130321037486	2.7537170275835923e-05
Signaling by hedgehog	57	122	2.132999606866728	3.387643674134751e-05
Telomere c strand lagging strand synthesis	23	37	3.978492036760814	3.377169316901164e-05
Sumoylation of chromatin organization proteins	32	58	2.9846153846153847	3.368059363673609e-05
Purine ribonucleoside monophosphate biosynthesis	10	11	24.154929577464788	3.781827440908035e-05
Complex i biogenesis	31	56	3.006403242147923	4.082886389249154e-05
Fc epsilon receptor fceri signaling	51	108	2.174323090964405	6.087509965695748e-05
Transcriptional regulation by runx1	66	149	1.9352296403659752	6.839981303002437e-05
Mitochondrial trna aminoacylation	16	23	5.527649769585254	7.654731594337344e-05
Copii mediated vesicle transport	30	55	2.9084402430790006	7.848347745003816e-05
Processing of intronless pre mrnas	15	21	6.044675848169298	8.043704640881161e-05
Glutathione conjugation	15	21	6.044675848169298	8.043704640881161e-05
Signaling by the b cell receptor bcr	44	91	2.27278501111464	9.581705027394405e-05
Hiv elongation arrest and recovery	20	32	4.033198743831314	9.90658798136889e-05
Pyruvate metabolism	17	26	4.568253968253968	0.0001490856177723
Nucleotide excision repair	52	114	2.0374369102479704	0.0001588123515869
Unwinding of dna	10	12	12.075788061703555	0.0001666970258168
Beta catenin independent wnt signaling	53	117	2.0118450153113305	0.0001717391877631
Golgi cisternae pericentriolar stack reorganization	11	14	8.857318573185731	0.0001961150554349
Rhod gtpase cycle	27	50	2.843126328909744	0.0002214942253144
Golgi associated vesicle biogenesis	29	55	2.7020691087515254	0.0002271849375427
Mapk family signaling cascades	86	212	1.6624280361376025	0.0002742443266681
Phase ii conjugation of compounds	28	53	2.712712550607288	0.0002779528404846
Rhog gtpase cycle	35	71	2.356742945177169	0.0003019623268229
Rho gtpases activate formins	58	133	1.8790365825948647	0.0003044232273844
G2 m dna damage checkpoint	33	66	2.423453869550524	0.0003191306201883
Cargo concentration in the er	15	23	4.532247228753779	0.0003858843489266
Ire1alpha activates chaperones	24	44	2.904582210242588	0.0004021536915468
Dual incision in tc ner	33	67	2.351847802317953	0.0004535828905337
Recognition of dna damage by pcna containing replication complex	18	30	3.627437794216543	0.0004569799592295
Condensation of prometaphase chromosomes	9	11	10.864565873281933	0.0004778551778947
Apoptosis induced dna fragmentation	9	11	10.864565873281933	0.0004778551778947
Hiv transcription elongation	23	42	2.9294818386484907	0.00049049015256
Dual incision in gg ner	23	42	2.9294818386484907	0.00049049015256
Nuclear events stimulated by alk signaling in cancer	12	17	5.797852348993288	0.0005188021872572
Mismatch repair	12	17	5.797852348993288	0.0005188021872572
Tristetraprolin ttp zfp36 binds and destabilizes mrna	12	17	5.797852348993288	0.0005188021872572
Transcriptional regulation by runx3	40	86	2.1085189112760694	0.0005384557857992
Cooperation of prefoldin and tric cct in actin and tubulin folding	17	28	3.7366233766233767	0.0005420705272
Clathrin mediated endocytosis	52	119	1.8840694486749925	0.0005750111250462
Interconversion of nucleotide di and triphosphates	16	26	3.867741935483871	0.0006398530775459
Nef mediated cd8 down regulation	6	6	inf	0.0006362839879295
Fgfr2 alternative splicing	16	26	3.867741935483871	0.0006398530775459
Tcf dependent signaling in response to wnt	60	142	1.777359997338036	0.0006575688585925
Formation of rna pol ii elongation complex	29	58	2.4215322308471143	0.0007228910993129
Antigen presentation folding assembly and peptide loading of class i mhc	15	24	4.028104355615272	0.0007505734425255
Cholesterol biosynthesis	15	24	4.028104355615272	0.0007505734425255
Branched chain amino acid catabolism	14	22	4.228676964405642	0.0008733699584858
Recycling pathway of l1	22	41	2.801169590643275	0.0009359336347261
Processing of capped intronless pre mrna	17	29	3.4247619047619047	0.0009536960604805
Response of mtb to phagocytosis	13	20	4.486692562221263	0.0010054635915399
Translesion synthesis by polh	13	20	4.486692562221263	0.0010054635915399
Biological oxidations	42	94	1.958174706649283	0.0010960595685099
Defects in biotin btn metabolism	7	8	16.89145728643216	0.0011092501353585
Recycling of eif2 gdp	7	8	16.89145728643216	0.0011092501353585
Dna replication initiation	7	8	16.89145728643216	0.0011092501353585
Chromosome maintenance	44	100	1.9051172707889128	0.0012422609443903
Processing of smdt1	11	16	5.312915129151292	0.0012685134835702
Deubiquitination	86	221	1.5496265708240933	0.0012872063442966
Folding of actin by cct tric	8	10	9.654155495978552	0.0013468020463368
Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex	10	14	6.036217303822937	0.0013691325828546
Signaling by wnt	83	213	1.552587460665838	0.0014781471468553
Global genome nucleotide excision repair gg ner	39	87	1.968929901794785	0.001505996128754
Abortive elongation of hiv 1 transcript in the absence of tat	14	23	3.7583016192821432	0.0016316809066586
Infection with mycobacterium tuberculosis	13	21	3.925310506881504	0.0019328392783177
Formation of tubulin folding intermediates by cct tric	13	21	3.925310506881504	0.0019328392783177
Polymerase switching on the c strand of the telomere	16	28	3.2222222222222223	0.0019484577658638
Tp53 regulates transcription of dna repair genes	29	61	2.1935960175497806	0.0019822016830253
Cargo trafficking to the periciliary membrane	22	43	2.5336860670194	0.0021192585882042
Beta oxidation of octanoyl coa to hexanoyl coa	5	5	inf	0.0021708637834203
Rho gtpases activate paks	12	19	4.140172579098754	0.0022721716436602
Perk regulates gene expression	15	26	3.2948056310501723	0.0023648751464266
Selective autophagy	31	67	2.084581034935645	0.0024187789398495
Metabolism of steroids	44	103	1.8074879838097648	0.0025250269279563
Translesion synthesis by y family dna polymerases bypasses lesions on dna template	21	41	2.5389431167956915	0.0026107321596981
Ldl clearance	11	17	4.426814268142682	0.0026429841934404
Butyrate response factor 1 brf1 binds and destabilizes mrna	11	17	4.426814268142682	0.0026429841934404
Rmts methylate histone arginines	19	36	2.701826240082309	0.0026534900963011
Aurka activation by tpx2	33	73	1.9973977695167289	0.0028484059718432
Defective intrinsic pathway for apoptosis	14	24	3.3820013431833447	0.00286523135656
Insulin receptor recycling	10	15	4.828303152246814	0.003028084890345
Adaptive immune system	176	504	1.3102134146341464	0.0031440088045153
Termination of translesion dna synthesis	18	34	2.71906523201076	0.003267780197715
Positive epigenetic regulation of rrna expression	28	60	2.1172402159244266	0.0032995101193504
Nef mediated cd4 down regulation	6	7	14.473543201607502	0.0033352770296439
Atf4 activates genes in response to endoplasmic reticulum stress	13	22	3.4886800193950243	0.0034631838513911
Response to elevated platelet cytosolic ca2	32	71	1.9861399861399864	0.0034678103860109
Glyoxylate metabolism and glycine degradation	13	22	3.4886800193950243	0.0034631838513911
Rho gtpases activate ktn1	8	11	6.435210008936551	0.0036639936955216
Hdr through mmej alt nhej	8	11	6.435210008936551	0.0036639936955216
Establishment of sister chromatid cohesion	8	11	6.435210008936551	0.0036639936955216
Biotin transport and metabolism	8	11	6.435210008936551	0.0036639936955216
Polb dependent long patch base excision repair	7	9	8.444556113902848	0.0037189542211699
Vldlr internalisation and degradation	7	9	8.444556113902848	0.0037189542211699
The role of nef in hiv 1 replication and disease pathogenesis	12	20	3.622147651006711	0.0041722337218625
Phosphorylation of the apc c	12	20	3.622147651006711	0.0041722337218625
Formation of tc ner pre incision complex	25	53	2.159468438538206	0.0044923963949516
Rho gtpases activate pkns	20	40	2.417227456258412	0.0046842870022161
Hsf1 activation	14	25	3.074119299102509	0.0047686729472692
Rho gtpases activate cit	11	18	3.79388508170796	0.0050034249172022
Transferrin endocytosis and recycling	11	18	3.79388508170796	0.0050034249172022
Activation of atr in response to replication stress	19	38	2.4167507568113016	0.0057864961305402
Regulation of plk1 activity at g2 m transition	37	87	1.7915262267343486	0.0058219294485457
Plasma lipoprotein clearance	13	23	3.139375629405841	0.0058441376793903
Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	10	16	4.023027051196065	0.0059607039016461
Meiosis	25	54	2.084713457224876	0.0060701274960753
Rho gtpases activate wasps and waves	17	33	2.567142857142857	0.0060630461587308
Protein folding	34	79	1.8286079182630908	0.0064340275101001
Dna damage bypass	23	49	2.138689535456124	0.0067805811341312
Formation of atp by chemiosmotic coupling	9	14	4.344016091183373	0.0070317046227954
Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components	12	21	3.21923937360179	0.0071580929800643
Processive synthesis on the c strand of the telomere	12	21	3.21923937360179	0.0071580929800643
Beta oxidation of lauroyl coa to decanoyl coa coa	4	4	inf	0.0074047669614467
L1cam interactions	38	91	1.7356574392253548	0.0075035404678559
Meiotic synapsis	16	31	2.5767025089605733	0.0075038253073779
Deadenylation of mrna	14	26	2.817550929035147	0.0075731037148639
Retrograde neurotrophin signalling	8	12	4.825737265415549	0.0081693218182727
Wnt5a dependent internalization of fzd2 fzd5 and ror2	8	12	4.825737265415549	0.0081693218182727
Rho gtpases activate rocks	11	19	3.319188191881919	0.0087588981682524
Insertion of tail anchored proteins into the endoplasmic reticulum membrane	11	19	3.319188191881919	0.0087588981682524
Fatty acyl coa biosynthesis	15	29	2.587696146648112	0.0092987673449348
Rhoc gtpase cycle	32	75	1.8003771213073538	0.0093589085288099
Beta oxidation of decanoyl coa to octanoyl coa coa	5	6	12.05724807499163	0.0098437627608459
Phenylalanine and tyrosine metabolism	5	6	12.05724807499163	0.0098437627608459
Dna repair	104	291	1.351282089264817	0.0098816467794069
Glutathione synthesis and recycling	6	8	7.2357669122572	0.0100133577125287
Translesion synthesis by polk	10	17	3.447829836159816	0.0107003034846685
Class i mhc mediated antigen processing presentation	105	295	1.342624833646291	0.0108912489181598
Epigenetic regulation of gene expression	41	102	1.6269172439462032	0.0119745555831038
Signaling by fgfr2	23	51	1.9853726603473996	0.0120949049114615
Apoptotic cleavage of cellular proteins	17	35	2.2812698412698413	0.0125925157964303
Metabolism of lipids	172	508	1.2467240797028032	0.0132361615558935
Reproduction	25	57	1.8884816312773849	0.0137225561906002
Iron uptake and transport	18	38	2.17404169468729	0.0141188687028533
Sensory processing of sound by outer hair cells of the cochlea	13	25	2.6154190444220657	0.0143436529196112
Formation of the early elongation complex	16	33	2.2729285262492094	0.0156088418449856
Mitochondrial fatty acid beta oxidation	16	33	2.2729285262492094	0.0156088418449856
Wnt5a dependent internalization of fzd4	8	13	3.860053619302949	0.0158138691440031
Early phase of hiv life cycle	8	13	3.860053619302949	0.0158138691440031
Regulation of cholesterol biosynthesis by srebp srebf	24	55	1.871054690896444	0.0166951698387642
Neddylation	68	185	1.4086662691313854	0.017042948355548
Association of tric cct with target proteins during biosynthesis	17	36	2.160902255639097	0.017457295820703
Vxpx cargo targeting to cilium	10	18	3.016431924882629	0.0178214016945027
Post chaperonin tubulin folding pathway	10	18	3.016431924882629	0.0178214016945027
Defects in vitamin and cofactor metabolism	10	18	3.016431924882629	0.0178214016945027
Lysine catabolism	7	11	4.221105527638191	0.0190364449285724
Suppression of phagosomal maturation	7	11	4.221105527638191	0.0190364449285724
Erks are inactivated	7	11	4.221105527638191	0.0190364449285724
Recruitment of numa to mitotic centrosomes	36	90	1.6125394677492106	0.0192575764440283
Diseases of programmed cell death	23	53	1.852498035253172	0.0203082854006492
Aggrephagy	16	34	2.146356033452808	0.0216093127119555
Piwi interacting rna pirna biogenesis	9	16	3.102006608878885	0.0221354017750442
Regulation of pyruvate dehydrogenase pdh complex	9	16	3.102006608878885	0.0221354017750442
Ros and rns production in phagocytes	9	16	3.102006608878885	0.0221354017750442
Depolymerisation of the nuclear lamina	9	16	3.102006608878885	0.0221354017750442
Trna modification in the mitochondrion	6	9	4.8231748158071	0.022602164695665
Apoptotic cleavage of cell adhesion proteins	6	9	4.8231748158071	0.022602164695665
Mitochondrial fatty acid beta oxidation of saturated fatty acids	6	9	4.8231748158071	0.022602164695665
Integration of provirus	6	9	4.8231748158071	0.022602164695665
Organelle biogenesis and maintenance	94	268	1.3104955458778549	0.0229999905189492
Semaphorin interactions	21	48	1.8788660757694755	0.0235043571375852
Formyl peptide receptors bind formyl peptides and many other ligands	3	3	inf	0.025251518781288
Sensory processing of sound	18	40	1.9758513174787555	0.0255022119851771
Hur elavl1 binds and stabilizes mrna	5	7	6.027787077335119	0.0261149770893629
Cd28 dependent vav1 pathway	5	7	6.027787077335119	0.0261149770893629
2 ltr circle formation	5	7	6.027787077335119	0.0261149770893629
Tysnd1 cleaves peroxisomal proteins	5	7	6.027787077335119	0.0261149770893629
Attachment of gpi anchor to upar	5	7	6.027787077335119	0.0261149770893629
Aspartate and asparagine metabolism	5	7	6.027787077335119	0.0261149770893629
Peroxisomal lipid metabolism	12	24	2.4134228187919464	0.0263600600002043
Microrna mirna biogenesis	12	24	2.4134228187919464	0.0263600600002043
Signaling by notch	56	152	1.412238873751135	0.0270229540211219
Dna double strand break repair	51	137	1.4352735582739615	0.0277316996070892
Wax and plasmalogen biosynthesis	4	5	9.6425702811245	0.0283403796736022
Maturation of sars cov 1 spike protein	4	5	9.6425702811245	0.0283403796736022
Beta oxidation of hexanoyl coa to butanoyl coa	4	5	9.6425702811245	0.0283403796736022
Mitochondrial fatty acid beta oxidation of unsaturated fatty acids	4	5	9.6425702811245	0.0283403796736022
Uptake and function of diphtheria toxin	4	5	9.6425702811245	0.0283403796736022
Scavenging by class f receptors	4	5	9.6425702811245	0.0283403796736022
Trna processing in the mitochondrion	4	5	9.6425702811245	0.0283403796736022
Cargo recognition for clathrin mediated endocytosis	31	78	1.5942500736525185	0.0311621504824843
Rac2 gtpase cycle	32	81	1.5785990071704357	0.0315205881846474
Attenuation phase	11	22	2.412948674941295	0.0329924613079947
Translation of sars cov 2 structural proteins	18	41	1.8896815882576528	0.0332900553899407
Hsf1 dependent transactivation	14	30	2.111987911349899	0.0332400846969684
Alpha linolenic omega3 and linoleic omega6 acid metabolism	7	12	3.37641541038526	0.0342504172831639
Mecp2 regulates neuronal receptors and channels	7	12	3.37641541038526	0.0342504172831639
Metabolism of steroid hormones	7	12	3.37641541038526	0.0342504172831639
Metabolism of porphyrins	9	17	2.713878645658733	0.0349998873515762
Transcription of the hiv genome	27	67	1.6309274873524453	0.0354718461208528
Apc cdc20 mediated degradation of nek2a	12	25	2.227465152297367	0.0374521280744974
Recruitment of mitotic centrosome proteins and complexes	32	82	1.5468108108108107	0.0375308447294757
Parasite infection	21	50	1.7488016341879549	0.037828282840152
Metabolism of water soluble vitamins and cofactors	35	91	1.5108217788298952	0.0380591366619263
Homology directed repair	40	106	1.46546768497988	0.038136234330725
Intracellular signaling by second messengers	81	233	1.2909562638991845	0.0403223592764706
Rnd3 gtpase cycle	17	39	1.8654545454545453	0.0407891595930028
Erk mapk targets	10	20	2.412474849094568	0.0414168787325853
Aberrant regulation of mitotic exit in cancer due to rb1 defects	10	20	2.412474849094568	0.0414168787325853
Met receptor recycling	6	10	3.6168787675820497	0.0426244477944975
Sting mediated induction of host immune responses	6	10	3.6168787675820497	0.0426244477944975
Mrna decay by 5 to 3 exoribonuclease	8	15	2.7564151666028343	0.044079179115471
Formation of senescence associated heterochromatin foci sahf	8	15	2.7564151666028343	0.044079179115471
Synthesis of pips at the golgi membrane	8	15	2.7564151666028343	0.044079179115471
Metabolism of folate and pterines	8	15	2.7564151666028343	0.044079179115471
Signaling by fgfr in disease	20	48	1.7246683330128822	0.0457873144341963
Apc c cdc20 mediated degradation of cyclin b	11	23	2.211562115621156	0.0468617193115226
E2f mediated regulation of dna replication	11	23	2.211562115621156	0.0468617193115226
Signaling by fgfr	23	57	1.6336457115685614	0.0489658643334655
Factors involved in megakaryocyte development and platelet production	43	117	1.404919670433404	0.0498036486950998
Dna damage recognition in gg ner	16	37	1.8389656938044037	0.0499879449351923
Processing of dna double strand break ends	26	66	1.5699932569116657	0.0508491869824116
Signaling by fgfr2 iiia tm	9	18	2.412001340931948	0.0521783730098097
Plasma lipoprotein assembly remodeling and clearance	17	40	1.7840993788819877	0.0520882078232365
Fcgamma receptor fcgr dependent phagocytosis	28	72	1.537234695129432	0.0515706406328507
Tp53 regulates metabolic genes	32	84	1.486902286902287	0.0520831740434214
Rnd2 gtpase cycle	17	40	1.7840993788819877	0.0520882078232365
Fgfr2 mutant receptor activation	9	18	2.412001340931948	0.0521783730098097
Irf3 mediated induction of type i ifn	5	8	4.017966744782949	0.0529510093835772
Miro gtpase cycle	5	8	4.017966744782949	0.0529510093835772
Chrebp activates metabolic gene expression	5	8	4.017966744782949	0.0529510093835772
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	5	8	4.017966744782949	0.0529510093835772
Pregnenolone biosynthesis	5	8	4.017966744782949	0.0529510093835772
Hyaluronan uptake and degradation	5	8	4.017966744782949	0.0529510093835772
Mrna capping	13	29	1.9604733131923464	0.0553202123643769
Pentose phosphate pathway	7	13	2.813288665549972	0.0557597234463358
Platelet activation signaling and aggregation	54	152	1.3327266917658829	0.057014400059201
Lysosome vesicle biogenesis	14	32	1.8768002387881504	0.0585616848881561
N glycan trimming in the er and calnexin calreticulin cycle	14	32	1.8768002387881504	0.0585616848881561
Protein ubiquitination	23	58	1.5867487850647164	0.0592889438978929
Mitochondrial biogenesis	32	85	1.458643549209587	0.0607336399860914
Rhov gtpase cycle	15	35	1.8098757138058448	0.0612728255048885
Mitophagy	11	24	2.041158103888731	0.064209277193306
Maturation of sars cov 2 spike protein	11	24	2.041158103888731	0.064209277193306
Suppression of apoptosis	4	6	4.820615796519411	0.0653336134985966
Alpha oxidation of phytanate	4	6	4.820615796519411	0.0653336134985966
Sensing of dna double strand breaks	4	6	4.820615796519411	0.0653336134985966
Keratan sulfate degradation	4	6	4.820615796519411	0.0653336134985966
Stat3 nuclear events downstream of alk signaling	4	6	4.820615796519411	0.0653336134985966
Activation of bad and translocation to mitochondria	8	16	2.4115281501340484	0.0660229564567453
Kinesins	19	47	1.63788381144587	0.0681976885719177
Ercc6 csb and ehmt2 g9a positively regulate rrna expression	12	27	1.9299328859060405	0.0686169685330476
Signaling by braf and raf1 fusions	21	53	1.584188825311343	0.0699980218675424
Eph ephrin signaling	30	80	1.4491559756921	0.0710305426014001
Trafficking of glur2 containing ampa receptors	6	11	2.89310113864702	0.0709300512347036
Rac3 gtpase cycle	31	83	1.439950120801185	0.0707226946199919
Synaptic adhesion like molecules	6	11	2.89310113864702	0.0709300512347036
Met activates rap1 and rac1	6	11	2.89310113864702	0.0709300512347036
Sphingolipid metabolism	24	62	1.5248971485317069	0.0713528589125066
Class i peroxisomal membrane protein import	9	19	2.17049949715052	0.0740371436661412
Glycosphingolipid metabolism	14	33	1.7777738503410978	0.075117199915713
Trafficking of myristoylated proteins to the cilium	3	4	7.229508196721311	0.0787917742419087
Mecp2 regulates transcription of neuronal ligands	3	4	7.229508196721311	0.0787917742419087
Phenylalanine metabolism	3	4	7.229508196721311	0.0787917742419087
Apobec3g mediated resistance to hiv 1 infection	3	4	7.229508196721311	0.0787917742419087
Arachidonate production from dag	3	4	7.229508196721311	0.0787917742419087
Glucuronidation	3	4	7.229508196721311	0.0787917742419087
Rhou gtpase cycle	16	39	1.6785881252921926	0.0793524770953423
Fgfr1 mutant receptor activation	10	22	2.009836798569193	0.0803116534394179
Vegfr2 mediated vascular permeability	10	22	2.009836798569193	0.0803116534394179
Activation of gene expression by srebf srebp	17	42	1.6409142857142858	0.080843349473322
Rhof gtpase cycle	17	42	1.6409142857142858	0.080843349473322
B wich complex positively regulates rrna expression	18	45	1.6088321004259134	0.0820025666264636
Peroxisomal protein import	20	51	1.5571137064212217	0.0835182127513684
Purine catabolism	7	14	2.411055276381909	0.0839960250534356
Oncogenic mapk signaling	25	66	1.4720872689010005	0.0841429306525995
Glutamate and glutamine metabolism	7	14	2.411055276381909	0.0839960250534356
Tyrosine catabolism	2	2	inf	0.0860916329291088
Hdl clearance	2	2	inf	0.0860916329291088
Hemostasis	118	361	1.17614428779665	0.0876796373289608
Gap junction trafficking and regulation	12	28	1.809060402684564	0.0890896240027276
Smooth muscle contraction	12	28	1.809060402684564	0.0890896240027276
Hyaluronan metabolism	5	9	3.013056578506863	0.0908870652447265
Beta oxidation of very long chain fatty acids	5	9	3.013056578506863	0.0908870652447265
Wnt ligand biogenesis and trafficking	5	9	3.013056578506863	0.0908870652447265
Pink1 prkn mediated mitophagy	8	17	2.143282692880548	0.0935990178830584
Transcriptional regulation by tp53	109	333	1.1781192706010604	0.0944339401360993
E3 ubiquitin ligases ubiquitinate target proteins	16	40	1.6084229390681004	0.097528656607084
Negative epigenetic regulation of rrna expression	23	61	1.4608675612912376	0.0991163071577092
Rhoj gtpase cycle	21	55	1.4905854634011126	0.0996192941382939
Rna polymerase i transcription initiation	19	49	1.528265500616661	0.0994902139088827
Dna double strand break response	19	49	1.528265500616661	0.0994902139088827
Trafficking of ampa receptors	9	20	1.9729070795111692	0.1007264513385376
Conversion from apc c cdc20 to apc c cdh1 in late anaphase	9	20	1.9729070795111692	0.1007264513385376
Glycogen metabolism	9	20	1.9729070795111692	0.1007264513385376
Antigen processing ubiquitination proteasome degradation	83	250	1.2022795248279652	0.1003321444690832
Darpp 32 events	9	20	1.9729070795111692	0.1007264513385376
Cilium assembly	62	183	1.2386709164245622	0.1017695672745711
Condensation of prophase chromosomes	10	23	1.8549760099055876	0.1060423719973359
Mtorc1 mediated signalling	10	23	1.8549760099055876	0.1060423719973359
Methylation	6	12	2.4105827193569995	0.1076096851859126
Gap junction degradation	6	12	2.4105827193569995	0.1076096851859126
Alk mutants bind tkis	6	12	2.4105827193569995	0.1076096851859126
Heme biosynthesis	6	12	2.4105827193569995	0.1076096851859126
Prolonged erk activation events	6	12	2.4105827193569995	0.1076096851859126
Rho gtpases activate iqgaps	11	26	1.7685116851168512	0.1100023218906654
Autophagy	45	130	1.2788878021517396	0.110189745736514
Ripk1 mediated regulated necrosis	11	26	1.7685116851168512	0.1100023218906654
Signaling by retinoic acid	11	26	1.7685116851168512	0.1100023218906654
Sars cov 2 infection	23	62	1.423210784948744	0.1154896227865943
Hdr through single strand annealing ssa	14	35	1.6080143272890084	0.1165337633293129
Activation of nima kinases nek9 nek6 nek7	4	7	3.213297634984382	0.1176251287122746
Rsk activation	4	7	3.213297634984382	0.1176251287122746
Dna damage telomere stress induced senescence	15	38	1.5731477559842852	0.1175148926034944
Beta oxidation of pristanoyl coa	4	7	3.213297634984382	0.1176251287122746
Nonhomologous end joining nhej	16	41	1.5438709677419356	0.11808871472557
Inlb mediated entry of listeria monocytogenes into host cell	7	15	2.1093802345058625	0.1189232652484941
Rhoa gtpase cycle	46	134	1.2626365487872615	0.1198877157759963
Signaling by cytosolic fgfr1 fusion mutants	8	18	1.928686327077748	0.1267355337838967
Arachidonic acid metabolism	8	18	1.928686327077748	0.1267355337838967
Tp53 regulates transcription of genes involved in g2 cell cycle arrest	8	18	1.928686327077748	0.1267355337838967
Telomere extension by telomerase	9	21	1.8082467314783772	0.1321690925363765
Insulin processing	9	21	1.8082467314783772	0.1321690925363765
Listeria monocytogenes entry into host cells	9	21	1.8082467314783772	0.1321690925363765
Rna polymerase i transcription	23	63	1.387436847423375	0.1334329768494666
Detoxification of reactive oxygen species	10	24	1.7222381910510682	0.1359231540052867
Cyclin a b1 b2 associated events during g2 m transition	10	24	1.7222381910510682	0.1359231540052867
Senescence associated secretory phenotype sasp	20	54	1.4191275433457369	0.1374199797550037
Rrna processing in the mitochondrion	5	10	2.410110478741212	0.1391496826914957
Metabolism of nitric oxide nos3 activation and regulation	5	10	2.410110478741212	0.1391496826914957
Cooperation of pdcl phlp1 and tric cct in g protein beta folding	11	27	1.6577490774907748	0.1384547523229692
E2f enabled inhibition of pre replication complex formation	5	10	2.410110478741212	0.1391496826914957
Regulation of tp53 activity through phosphorylation	29	82	1.3205573137882949	0.1404169106471797
Regulation of localization of foxo transcription factors	6	13	2.0659267055784136	0.1520525095367466
Synthesis of gdp mannose	3	5	3.614252258280361	0.154468866094414
Sema3a pak dependent axon repulsion	6	13	2.0659267055784136	0.1520525095367466
Signaling by receptor tyrosine kinases	110	344	1.1368826254322435	0.1515029318643267
G2 m dna replication checkpoint	3	5	3.614252258280361	0.154468866094414
P75ntr regulates axonogenesis	3	5	3.614252258280361	0.154468866094414
Glycogen breakdown glycogenolysis	6	13	2.0659267055784136	0.1520525095367466
Propionyl coa catabolism	3	5	3.614252258280361	0.154468866094414
Ethanol oxidation	3	5	3.614252258280361	0.154468866094414
Rho gtpases activate nadph oxidases	6	13	2.0659267055784136	0.1520525095367466
Formation of xylulose 5 phosphate	3	5	3.614252258280361	0.154468866094414
Beta oxidation of butanoyl coa to acetyl coa	3	5	3.614252258280361	0.154468866094414
Inhibition of replication initiation of damaged dna by rb1 e2f1	6	13	2.0659267055784136	0.1520525095367466
Maturation of sars cov 2 nucleoprotein	6	13	2.0659267055784136	0.1520525095367466
Met activates ptpn11	3	5	3.614252258280361	0.154468866094414
Synthesis secretion and deacylation of ghrelin	3	5	3.614252258280361	0.154468866094414
Diseases of mismatch repair mmr	3	5	3.614252258280361	0.154468866094414
Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation	3	5	3.614252258280361	0.154468866094414
Cytosolic iron sulfur cluster assembly	6	13	2.0659267055784136	0.1520525095367466
Synthesis of pips at the er membrane	3	5	3.614252258280361	0.154468866094414
Diseases associated with glycosylation precursor biosynthesis	7	16	1.8747440908244928	0.1600679498656452
Protein methylation	7	16	1.8747440908244928	0.1600679498656452
Cell extracellular matrix interactions	7	16	1.8747440908244928	0.1600679498656452
Chaperone mediated autophagy	7	16	1.8747440908244928	0.1600679498656452
Nucleotide catabolism	9	22	1.6689187446813998	0.1680703965254052
Signaling by fgfr2 in disease	11	28	1.5600173648795312	0.1703968941761821
Meiotic recombination	12	31	1.5227834687389614	0.1703746279924336
Rhoq gtpase cycle	21	59	1.3329376959733563	0.179524817705528
Prevention of phagosomal lysosomal fusion	4	8	2.409638554216868	0.1822992480391213
Mapk3 erk1 activation	4	8	2.409638554216868	0.1822992480391213
Interleukin 6 signaling	4	8	2.409638554216868	0.1822992480391213
Synthesis of udp n acetyl glucosamine	4	8	2.409638554216868	0.1822992480391213
Synthesis of prostaglandins pg and thromboxanes tx	4	8	2.409638554216868	0.1822992480391213
Dna damage reversal	4	8	2.409638554216868	0.1822992480391213
Glycogen synthesis	5	11	2.008146412230778	0.1959993755727593
Hdr through homologous recombination hrr	23	66	1.2900984592729523	0.1963660469081763
Ptk6 regulates proteins involved in rna processing	2	3	4.818060200668897	0.207771861225997
Spry regulation of fgf signaling	6	14	1.8074346952444744	0.2030948729002972
Binding and uptake of ligands by scavenger receptors	7	17	1.6870351758793969	0.2065962022509203
Peptide ligand binding receptors	7	17	1.6870351758793969	0.2065962022509203
Activation of bh3 only proteins	11	29	1.4731447314473145	0.2055174732184986
Nephrin family interactions	7	17	1.6870351758793969	0.2065962022509203
Signaling by fgfr1 in disease	11	29	1.4731447314473145	0.2055174732184986
Neurotransmitter clearance	2	3	4.818060200668897	0.207771861225997
Negative regulation of met activity	8	20	1.606791778373548	0.2079517585817872
Sema4d in semaphorin signaling	9	23	1.549494755998276	0.2079455551447337
Synthesis of very long chain fatty acyl coas	7	17	1.6870351758793969	0.2065962022509203
Organic anion transporters	2	3	4.818060200668897	0.207771861225997
Anchoring of the basal body to the plasma membrane	32	95	1.2253968253968257	0.2046880746109024
Sealing of the nuclear envelope ne by escrt iii	10	26	1.506539235412475	0.2070382767879614
Signal transduction by l1	8	20	1.606791778373548	0.2079517585817872
Diseases of carbohydrate metabolism	9	23	1.549494755998276	0.2079455551447337
Activated ntrk2 signals through cdk5	2	3	4.818060200668897	0.207771861225997
Assembly of the orc complex at the origin of replication	8	20	1.606791778373548	0.2079517585817872
Signaling by insulin receptor	16	45	1.3301816833518725	0.2229175867816567
Regulated necrosis	15	42	1.3393423655432388	0.2269753944651651
Tbc rabgaps	14	39	1.349979852249832	0.2310762712564648
Estrogen dependent gene expression	30	90	1.2059419311276165	0.2339715136951847
Rnd1 gtpase cycle	13	36	1.362479384678255	0.2352018840604809
Signaling by nuclear receptors	57	178	1.1368381038196742	0.2376612110306682
Regulation of tp53 activity through acetylation	11	30	1.3954165857448049	0.2434053661863516
Phosphorylation of emi1	3	6	2.409166945466711	0.243604118687407
Adenylate cyclase inhibitory pathway	3	6	2.409166945466711	0.243604118687407
Synthesis of ketone bodies	3	6	2.409166945466711	0.243604118687407
Vitamin c ascorbate metabolism	3	6	2.409166945466711	0.243604118687407
Negative feedback regulation of mapk pathway	3	6	2.409166945466711	0.243604118687407
Phosphate bond hydrolysis by nudt proteins	3	6	2.409166945466711	0.243604118687407
Aflatoxin activation and detoxification	3	6	2.409166945466711	0.243604118687407
Pp2a mediated dephosphorylation of key metabolic factors	3	6	2.409166945466711	0.243604118687407
Oas antiviral response	3	6	2.409166945466711	0.243604118687407
Collagen biosynthesis and modifying enzymes	11	30	1.3954165857448049	0.2434053661863516
Biosynthesis of specialized proresolving mediators spms	3	6	2.409166945466711	0.243604118687407
Methionine salvage pathway	3	6	2.409166945466711	0.243604118687407
Endosomal sorting complex required for transport escrt	11	30	1.3954165857448049	0.2434053661863516
Leishmania infection	36	110	1.1734264711260651	0.2465056962472694
Mapk targets nuclear events mediated by map kinases	10	27	1.4177220183848187	0.2473815264723382
Unblocking of nmda receptors glutamate binding and activation	4	9	1.9274431057563588	0.2554289942813101
Nef mediated downregulation of mhc class i complex cell surface expression	4	9	1.9274431057563588	0.2554289942813101
Creb1 phosphorylation through nmda receptor mediated activation of ras signaling	8	21	1.482986182718086	0.2545872453835961
Small interfering rna sirna biogenesis	4	9	1.9274431057563588	0.2554289942813101
Mucopolysaccharidoses	4	9	1.9274431057563588	0.2554289942813101
Rhobtb3 atpase cycle	4	9	1.9274431057563588	0.2554289942813101
Role of abl in robo slit signaling	4	9	1.9274431057563588	0.2554289942813101
Purine salvage	5	12	1.721029221866182	0.2591348687049186
Crmps in sema3a signaling	5	12	1.721029221866182	0.2591348687049186
Caspase mediated cleavage of cytoskeletal proteins	5	12	1.721029221866182	0.2591348687049186
Sema4d induced cell migration and growth cone collapse	7	18	1.5334551545606825	0.2574166276436418
Bbsome mediated cargo targeting to cilium	7	18	1.5334551545606825	0.2574166276436418
Raf independent mapk1 3 activation	6	15	1.6063853538736326	0.2592092779998297
Signaling by ctnnb1 phospho site mutants	6	15	1.6063853538736326	0.2592092779998297
Carnitine metabolism	5	12	1.721029221866182	0.2591348687049186
Ephb mediated forward signaling	14	40	1.2978767370976907	0.2652186213149657
Transcriptional regulation by ventx	13	37	1.3055275819626273	0.2711160605530528
Ion channel transport	27	82	1.1836455618580408	0.272970324196228
Rna polymerase ii transcribes snrna genes	24	73	1.1807580174927117	0.2917659366946147
Inhibition of dna recombination at telomere	10	28	1.3387733810269022	0.290150766634475
Synthesis of substrates in n glycan biosythesis	15	44	1.2466264348510998	0.2936401916154829
Digestion and absorption	1	1	inf	0.2934484111360748
Synthesis of lipoxins lx	1	1	inf	0.2934484111360748
Digestion	1	1	inf	0.2934484111360748
Assembly and cell surface presentation of nmda receptors	10	28	1.3387733810269022	0.290150766634475
Biosynthesis of maresins	1	1	inf	0.2934484111360748
Passive transport by aquaporins	1	1	inf	0.2934484111360748
Synthesis of epoxy eet and dihydroxyeicosatrienoic acids dhet	1	1	inf	0.2934484111360748
Homologous dna pairing and strand exchange	14	41	1.2496331119568191	0.3009681565305178
Sulfur amino acid metabolism	8	22	1.3768671007276905	0.3040254447272014
Egfr downregulation	8	22	1.3768671007276905	0.3040254447272014
Rab geranylgeranylation	18	54	1.2051109616677875	0.3048542453554537
Diseases of mitotic cell cycle	13	38	1.2531319234642495	0.308682593200536
Esr mediated signaling	43	136	1.1149141134045804	0.3083070255347687
Striated muscle contraction	6	16	1.4455458807769592	0.3186940748817347
Basigin interactions	6	16	1.4455458807769592	0.3186940748817347
Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	6	16	1.4455458807769592	0.3186940748817347
Beta catenin phosphorylation cascade	6	16	1.4455458807769592	0.3186940748817347
Sphingolipid de novo biosynthesis	10	29	1.2681351265487664	0.3346946052823376
Metabolic disorders of biological oxidation enzymes	5	13	1.5056913290927352	0.3260613431922813
Nef and signal transduction	2	4	2.408695652173913	0.3367519482112816
Reduction of cytosolic ca levels	3	7	1.8066242890598865	0.3380883611733909
Dissolution of fibrin clot	3	7	1.8066242890598865	0.3380883611733909
Runx1 regulates expression of components of tight junctions	2	4	2.408695652173913	0.3367519482112816
Glycerophospholipid catabolism	2	4	2.408695652173913	0.3367519482112816
The nlrp3 inflammasome	4	10	1.6059794734493529	0.3329485353303352
Transport and synthesis of paps	2	4	2.408695652173913	0.3367519482112816
Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation	3	7	1.8066242890598865	0.3380883611733909
Synthesis of leukotrienes lt and eoxins ex	2	4	2.408695652173913	0.3367519482112816
Signaling by mapk mutants	2	4	2.408695652173913	0.3367519482112816
Apex1 independent resolution of ap sites via the single nucleotide replacement pathway	3	7	1.8066242890598865	0.3380883611733909
Disinhibition of snare formation	2	4	2.408695652173913	0.3367519482112816
Telomere c strand synthesis initiation	5	13	1.5056913290927352	0.3260613431922813
Aryl hydrocarbon receptor signalling	3	7	1.8066242890598865	0.3380883611733909
Ketone body metabolism	3	7	1.8066242890598865	0.3380883611733909
Met interacts with tns proteins	2	4	2.408695652173913	0.3367519482112816
Heme degradation	3	7	1.8066242890598865	0.3380883611733909
Interleukin 9 signaling	2	4	2.408695652173913	0.3367519482112816
Endosomal vacuolar pathway	4	10	1.6059794734493529	0.3329485353303352
Triglyceride catabolism	5	13	1.5056913290927352	0.3260613431922813
Stat5 activation	2	4	2.408695652173913	0.3367519482112816
Proton coupled monocarboxylate transport	2	4	2.408695652173913	0.3367519482112816
Mastl facilitates mitotic progression	4	10	1.6059794734493529	0.3329485353303352
G1 s specific transcription	10	29	1.2681351265487664	0.3346946052823376
Gamma carboxylation hypusine formation and arylsulfatase activation	10	29	1.2681351265487664	0.3346946052823376
Enos activation	3	7	1.8066242890598865	0.3380883611733909
Interleukin 6 family signaling	4	10	1.6059794734493529	0.3329485353303352
Phase i functionalization of compounds	13	39	1.2047667002349782	0.3474857541722142
Mtor signalling	13	39	1.2047667002349782	0.3474857541722142
Epha mediated growth cone collapse	8	23	1.2848972296693475	0.3552680524966378
Signaling by ptk6	12	36	1.2046979865771812	0.3576475327844158
Signaling by ntrks	32	102	1.1017760617760617	0.361095559049535
Rhob gtpase cycle	22	69	1.1279747832939322	0.3639639335938904
Metalloprotease dubs	7	20	1.2971781986857365	0.3669342422205733
Nucleotide salvage	7	20	1.2971781986857365	0.3669342422205733
Cell cell communication	25	79	1.11566740316319	0.3663342512436973
Glycerophospholipid biosynthesis	27	86	1.1027810329550976	0.3764216563937452
Tp53 regulates transcription of cell cycle genes	14	43	1.163127301359394	0.375831093557675
Regulation of tp53 activity	45	146	1.0738727418720837	0.376671508898309
Intrinsic pathway for apoptosis	17	53	1.1377777777777778	0.380146241881672
Miscellaneous transport and binding events	6	17	1.3139499482433172	0.3798383690403198
Negative regulation of fgfr4 signaling	6	17	1.3139499482433172	0.3798383690403198
Negative regulation of fgfr3 signaling	6	17	1.3139499482433172	0.3798383690403198
Negative regulation of fgfr2 signaling	6	17	1.3139499482433172	0.3798383690403198
Negative regulation of fgfr1 signaling	6	17	1.3139499482433172	0.3798383690403198
Akt phosphorylates targets in the cytosol	5	14	1.3382063013800545	0.394376048910494
Constitutive signaling by egfrviii	5	14	1.3382063013800545	0.394376048910494
Cytosolic sulfonation of small molecules	5	14	1.3382063013800545	0.394376048910494
Transport of connexons to the plasma membrane	5	14	1.3382063013800545	0.394376048910494
Budding and maturation of hiv virion	9	27	1.2044921220248073	0.3931811923219611
Gastrin creb signalling pathway via pkc and mapk	5	14	1.3382063013800545	0.394376048910494
Rna polymerase ii transcription	288	969	1.0202017569011808	0.4061762295489404
Metabolism of vitamins and cofactors	41	134	1.0623371701956326	0.4063290166162369
Generation of second messenger molecules	4	11	1.3763625932300632	0.4112051980501888
Long term potentiation	4	11	1.3763625932300632	0.4112051980501888
Regulation of glycolysis by fructose 2 6 bisphosphate metabolism	4	11	1.3763625932300632	0.4112051980501888
Met activates ras signaling	4	11	1.3763625932300632	0.4112051980501888
Diseases of metabolism	40	131	1.0591441079245958	0.4142259774431254
Class a 1 rhodopsin like receptors	7	21	1.204355108877722	0.4231077406436607
Map2k and mapk activation	10	31	1.147040976014819	0.4264187260832318
Signaling by mras complex mutants	3	8	1.4450986952157912	0.4315618290558272
Inactivation of cdc42 and rac1	3	8	1.4450986952157912	0.4315618290558272
Ion homeostasis	10	31	1.147040976014819	0.4264187260832318
Vitamin d calciferol metabolism	3	8	1.4450986952157912	0.4315618290558272
Interferon alpha beta signaling	10	31	1.147040976014819	0.4264187260832318
Displacement of dna glycosylase by apex1	3	8	1.4450986952157912	0.4315618290558272
Interleukin 27 signaling	3	8	1.4450986952157912	0.4315618290558272
Regulation of ifna signaling	3	8	1.4450986952157912	0.4315618290558272
Rna polymerase iii transcription initiation from type 1 promoter	10	31	1.147040976014819	0.4264187260832318
Synthesis of diphthamide eef2	3	8	1.4450986952157912	0.4315618290558272
Sema4d mediated inhibition of cell attachment and migration	3	8	1.4450986952157912	0.4315618290558272
Lipophagy	3	8	1.4450986952157912	0.4315618290558272
Transport of vitamins nucleosides and related molecules	7	21	1.204355108877722	0.4231077406436607
Activation of the ap 1 family of transcription factors	3	8	1.4450986952157912	0.4315618290558272
Integration of energy metabolism	22	71	1.0816326530612246	0.4242336872563172
Neurexins and neuroligins	9	28	1.1409390052402208	0.4419850781713734
Tgf beta receptor signaling activates smads	9	28	1.1409390052402208	0.4419850781713734
Adherens junctions interactions	6	18	1.204286671131949	0.4410492397467304
Fbxw7 mutants and notch1 in cancer	2	5	1.6055741360089186	0.458274002951101
Interleukin 23 signaling	2	5	1.6055741360089186	0.458274002951101
Sumo is conjugated to e1 uba2 sae1	2	5	1.6055741360089186	0.458274002951101
Interleukin 21 signaling	2	5	1.6055741360089186	0.458274002951101
Cd163 mediating an anti inflammatory response	2	5	1.6055741360089186	0.458274002951101
Fructose metabolism	2	5	1.6055741360089186	0.458274002951101
Myoclonic epilepsy of lafora	2	5	1.6055741360089186	0.458274002951101
Synthesis of pi	2	5	1.6055741360089186	0.458274002951101
Chylomicron assembly	2	5	1.6055741360089186	0.458274002951101
Galactose catabolism	2	5	1.6055741360089186	0.458274002951101
P75ntr negatively regulates cell cycle via sc1	2	5	1.6055741360089186	0.458274002951101
Pd 1 signaling	2	5	1.6055741360089186	0.458274002951101
Ptk6 regulates cell cycle	2	5	1.6055741360089186	0.458274002951101
Acyl chain remodeling of cl	2	5	1.6055741360089186	0.458274002951101
Arms mediated activation	2	5	1.6055741360089186	0.458274002951101
Rhot1 gtpase cycle	2	5	1.6055741360089186	0.458274002951101
Signaling by wnt in cancer	8	25	1.1334174420438416	0.4592530866816477
Platelet sensitization by ldl	5	15	1.2042182792099096	0.4619594343599049
Gap junction assembly	5	15	1.2042182792099096	0.4619594343599049
Rab gefs exchange gtp for gdp on rabs	24	79	1.0510659152168589	0.4619614884586333
Growth hormone receptor signaling	5	15	1.2042182792099096	0.4619594343599049
Nuclear events kinase and transcription factor activation	13	42	1.0796842263661723	0.4670336914638366
Formation of incision complex in gg ner	13	42	1.0796842263661723	0.4670336914638366
Rna polymerase i promoter escape	13	42	1.0796842263661723	0.4670336914638366
Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein	18	59	1.0574081060245706	0.4708911927950181
Rna polymerase i transcription termination	10	32	1.094750320102433	0.4723010351743333
Signaling by csf3 g csf	7	22	1.1239084310441094	0.4786794787334251
Signal amplification	7	22	1.1239084310441094	0.4786794787334251
Flt3 signaling in disease	7	22	1.1239084310441094	0.4786794787334251
Translation of sars cov 1 structural proteins	7	22	1.1239084310441094	0.4786794787334251
Muscle contraction	25	83	1.0381437188382552	0.4795677841706032
Interaction between l1 and ankyrins	4	12	1.2041499330655958	0.4872403627234796
Costimulation by the cd28 family	12	39	1.0703952274422073	0.4824923970858958
Purinergic signaling in leishmaniasis infection	4	12	1.2041499330655958	0.4872403627234796
Rab regulation of trafficking	32	107	1.0276036036036036	0.485643977921301
Synthesis secretion and inactivation of glucagon like peptide 1 glp 1	4	12	1.2041499330655958	0.4872403627234796
Regulation of pten gene transcription	17	56	1.04981684981685	0.4840980393535641
Activation of rac1	4	12	1.2041499330655958	0.4872403627234796
Inflammasomes	4	12	1.2041499330655958	0.4872403627234796
Loss of function of mecp2 in rett syndrome	4	12	1.2041499330655958	0.4872403627234796
Mitochondrial iron sulfur cluster biogenesis	4	12	1.2041499330655958	0.4872403627234796
Cytosolic sensors of pathogen associated dna	17	56	1.04981684981685	0.4840980393535641
Phospholipid metabolism	43	156	0.915003435993002	0.7165863463128426
Runx2 regulates genes involved in cell migration	1	5	0.6018054162487463	0.8239879431862632
Runx2 regulates bone development	3	26	0.313366401442972	0.9919433614038574
Ldl remodeling	1	2	2.4082246740220663	0.5008051893494083
Runx1 regulates transcription of genes involved in differentiation of myeloid cells	1	5	0.6018054162487463	0.8239879431862632
Runx1 regulates transcription of genes involved in interleukin signaling	0	4	0.0	1.0
Runx1 regulates transcription of genes involved in wnt signaling	0	3	0.0	1.0
Runx1 regulates transcription of genes involved in differentiation of keratinocytes	0	4	0.0	1.0
Runx1 regulates transcription of genes involved in bcr signaling	0	4	0.0	1.0
Dag and ip3 signaling	7	30	0.7321680868108659	0.8214386241493598
Runx2 regulates chondrocyte maturation	0	3	0.0	1.0
Runx1 interacts with co factors whose precise effect on runx1 targets is not known	11	36	1.059630996309963	0.4992096541396956
Synthesis of glycosylphosphatidylinositol gpi	0	12	0.0	1.0
Vldl clearance	0	4	0.0	1.0
Hdl remodeling	0	3	0.0	1.0
Runx2 regulates osteoblast differentiation	2	20	0.2670382757339279	0.9911014099285992
Chylomicron remodeling	0	4	0.0	1.0
Chylomicron clearance	0	4	0.0	1.0
Transcriptional regulation by e2f6	6	34	0.5149746435747775	0.9604315162740188
Runx3 regulates bcl2l11 bim transcription	0	5	0.0	1.0
Runx3 regulates p14 arf	1	11	0.2405215646940822	0.9781420785502122
Removal of aminoterminal propeptides from gamma carboxylated proteins	0	4	0.0	1.0
Runx3 regulates yap1 mediated transcription	0	6	0.0	1.0
Gamma carboxylation transport and amino terminal cleavage of proteins	1	5	0.6018054162487463	0.8239879431862632
Recycling of bile acids and salts	0	6	0.0	1.0
Carboxyterminal post translational modifications of tubulin	6	25	0.7598618112595622	0.786880197836483
Activation of matrix metalloproteinases	0	6	0.0	1.0
Runx3 regulates wnt signaling	1	8	0.3437455222811291	0.9379623427931464
Zbp1 dai mediated induction of type i ifns	4	18	0.6875119525721936	0.8205132217227086
Irf3 mediated activation of type 1 ifn	1	3	1.2039451688398528	0.6473218534129999
Sulfide oxidation to sulfate	1	5	0.6018054162487463	0.8239879431862632
Polo like kinase mediated events	3	16	0.5551895411380189	0.8908482493424653
Runx3 regulates immune response and cell migration	0	4	0.0	1.0
Fibronectin matrix formation	1	3	1.2039451688398528	0.6473218534129999
Degradation of cysteine and homocysteine	3	12	0.8023865283818445	0.7313126477609548
Elastic fibre formation	1	23	0.1091456186742044	0.999664397240253
G0 and early g1	5	26	0.5725604604077988	0.9166742426731276
Assembly of active lpl and lipc lipase complexes	1	7	0.401092165385044	0.9121715035098086
Hdl assembly	1	6	0.4813774657305249	0.8756637428026797
Regulation of pten localization	1	8	0.3437455222811291	0.9379623427931464
Competing endogenous rnas cernas regulate pten translation	1	8	0.3437455222811291	0.9379623427931464
Plasma lipoprotein assembly	3	12	0.8023865283818445	0.7313126477609548
Collagen chain trimerization	0	13	0.0	1.0
Plasma lipoprotein remodeling	2	12	0.4812040133779264	0.9075099812904824
Regulation of pten mrna translation	1	9	0.3007355399531929	0.9561814898792792
Runx3 regulates notch signaling	1	11	0.2405215646940822	0.9781420785502122
Signaling by activin	2	9	0.6877209746774964	0.7922091662556401
Runx3 regulates cdkn1a transcription	1	7	0.401092165385044	0.9121715035098086
Cd28 co stimulation	7	24	0.99140802049463	0.5842864352535018
Synthesis of active ubiquitin roles of e1 and e2 enzymes	8	26	1.0703008638665474	0.5102183235563419
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function	11	39	0.9457037427517132	0.621795029403864
P38mapk events	2	13	0.4373973852234721	0.9301401965681808
Platelet aggregation plug formation	5	20	0.8022542126994755	0.7426880917621369
Rna polymerase iii transcription initiation from type 3 promoter	5	30	0.4806829594911282	0.9645851332924128
Signaling by tgf beta receptor complex	19	67	0.9527693687633144	0.6161694531409745
Adenylate cyclase activating pathway	0	3	0.0	1.0
Ddx58 ifih1 mediated induction of interferon alpha beta	13	57	0.7101223717537917	0.8935610207486278
Ticam1 rip1 mediated ikk complex recruitment	3	16	0.5551895411380189	0.8908482493424653
Toll like receptor cascades	26	103	0.8113686717867432	0.8482366022704928
Neurotoxicity of clostridium toxins	0	8	0.0	1.0
Tnf signaling	5	39	0.3530002560113432	0.9958082107547568
Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways	10	42	0.7515928906773978	0.8308770083779342
Toll like receptor tlr1 tlr2 cascade	19	70	0.8963481793659274	0.6999657020837267
Toll like receptor 9 tlr9 cascade	21	75	0.935898874303452	0.6438182694468256
Slbp dependent processing of replication dependent histone pre mrnas	3	10	1.031926587965397	0.5996338369181741
Trafficking and processing of endosomal tlr	2	8	0.8024526198439242	0.7316356285104274
Transport of fatty acids	1	3	1.2039451688398528	0.6473218534129999
The fatty acid cycling model	0	1	0.0	1.0
Interferon gamma signaling	12	51	0.7398038203407331	0.8582578855024988
Regulation of ifng signaling	3	10	1.031926587965397	0.5996338369181741
Hiv transcription initiation	13	45	0.9780547163477676	0.5829215706476896
Nod1 2 signaling pathway	6	30	0.601138647019424	0.9122157934436538
Transport of organic anions	0	3	0.0	1.0
Platelet adhesion to exposed collagen	1	7	0.401092165385044	0.9121715035098086
Trail signaling	0	6	0.0	1.0
Acetylcholine binding and downstream events	0	2	0.0	1.0
Death receptor signalling	18	120	0.4214169864314253	0.9999275634054624
Norepinephrine neurotransmitter release cycle	0	12	0.0	1.0
Serotonin neurotransmitter release cycle	0	14	0.0	1.0
Base excision repair ap site formation	5	23	0.6682661905293308	0.8495505493646256
Rip mediated nfkb activation via zbp1	4	16	0.8023203926818384	0.7360995100844776
Shc1 events in egfr signaling	1	7	0.401092165385044	0.9121715035098086
Rna polymerase iii transcription termination	6	24	0.8021879883902657	0.7499274740177471
Rna polymerase iii transcription	11	44	0.8018562003801856	0.7856499149590389
Alternative complement activation	0	1	0.0	1.0
Gab1 signalosome	3	10	1.031926587965397	0.5996338369181741
Irs activation	0	4	0.0	1.0
Signal attenuation	3	9	1.2040816326530612	0.5196282464541333
Insulin receptor signalling cascade	6	31	0.5770127260549229	0.9276030862003526
Signaling by egfr	12	40	1.0320230105465005	0.5233766293220338
Assembly of the hiv virion	2	15	0.3700025726781579	0.9606307441557927
Activation of c3 and c5	0	1	0.0	1.0
Mrna editing	1	4	0.8025186671124485	0.7508451551458319
Triglyceride biosynthesis	1	7	0.401092165385044	0.9121715035098086
Fasl cd95l signaling	1	5	0.6018054162487463	0.8239879431862632
Chondroitin sulfate dermatan sulfate metabolism	4	32	0.3430866322432587	0.993291517373001
Erbb2 activates ptk6 signaling	0	3	0.0	1.0
Signalling to ras	3	16	0.5551895411380189	0.8908482493424653
Terminal pathway of complement	0	1	0.0	1.0
Negative regulation of activity of tfap2 ap 2 family transcription factors	0	7	0.0	1.0
Activation of the tfap2 ap 2 family of transcription factors	0	8	0.0	1.0
Tfap2 ap 2 family regulates transcription of growth factors and their receptors	1	7	0.401092165385044	0.9121715035098086
Tfap2 ap 2 family regulates transcription of cell cycle factors	0	5	0.0	1.0
Signaling by egfr in cancer	5	17	1.0032362459546926	0.5884307536605788
Met activates ptk2 signaling	2	19	0.2827857564430454	0.9879599699433071
Creb3 factors activate genes	0	3	0.0	1.0
Heparan sulfate heparin hs gag metabolism	5	32	0.4449528202457563	0.9774631579137176
Keratan sulfate keratin metabolism	5	17	1.0032362459546926	0.5884307536605788
Pka activation in glucagon signalling	3	12	0.8023865283818445	0.7313126477609548
Met promotes cell motility	7	29	0.7655550479671083	0.7912410887123539
Inla mediated entry of listeria monocytogenes into host cells	2	9	0.6877209746774964	0.7922091662556401
Runx1 and foxp3 control the development of regulatory t lymphocytes tregs	0	3	0.0	1.0
Glucagon signaling in metabolic regulation	4	21	0.56595007480904	0.9043043121411438
Pka mediated phosphorylation of key metabolic factors	1	4	0.8025186671124485	0.7508451551458319
Post translational modification synthesis of gpi anchored proteins	7	32	0.6734070351758794	0.8714557404830116
Gaba synthesis release reuptake and degradation	2	12	0.4812040133779264	0.9075099812904824
Runx1 regulates estrogen receptor mediated transcription	1	5	0.6018054162487463	0.8239879431862632
Regulation of runx1 expression and activity	3	17	0.515461453902404	0.9142722919386124
Receptor mediated mitophagy	3	10	1.031926587965397	0.5996338369181741
Ampk inhibits chrebp transcriptional activation activity	0	7	0.0	1.0
Pi metabolism	17	71	0.7566137566137566	0.8728598145597574
Vldl assembly	1	3	1.2039451688398528	0.6473218534129999
Reelin signalling pathway	0	3	0.0	1.0
Ptk6 regulates rtks and their effectors akt1 and dok1	1	7	0.401092165385044	0.9121715035098086
Ptk6 regulates rho gtpases ras gtpase and map kinases	4	13	1.0702067529376766	0.5588754825262198
Ptk6 expression	1	2	2.4082246740220663	0.5008051893494083
Initial triggering of complement	0	1	0.0	1.0
Phosphate bond hydrolysis by ntpdase proteins	0	4	0.0	1.0
Butyrophilin btn family interactions	0	5	0.0	1.0
Complement cascade	1	10	0.2672833314759092	0.969051322224564
Met activates pi3k akt signaling	2	6	1.2040133779264215	0.5656089450744413
The activation of arylsulfatases	1	8	0.3437455222811291	0.9379623427931464
Signaling by mst1	1	3	1.2039451688398528	0.6473218534129999
Signaling by fgfr3 fusions in cancer	1	10	0.2672833314759092	0.969051322224564
Ret signaling	5	26	0.5725604604077988	0.9166742426731276
Mitochondrial uncoupling	0	1	0.0	1.0
Myd88 independent tlr4 cascade	20	78	0.8291177426091799	0.7998147856249199
Interleukin 20 family signaling	3	11	0.9028103044496488	0.6702945765004975
Synthesis of pips at the late endosome membrane	3	10	1.031926587965397	0.5996338369181741
Synthesis of pips at the early endosome membrane	4	16	0.8023203926818384	0.7360995100844776
Synthesis of pips at the plasma membrane	9	47	0.5689609541789439	0.9602695077490015
Ptk6 promotes hif1a stabilization	0	2	0.0	1.0
Downregulation of erbb2 signaling	5	18	0.9259354639334552	0.6451159513320872
Transcriptional regulation by the ap 2 tfap2 family of transcription factors	5	27	0.5464588976473811	0.9322710956586476
Glycosaminoglycan metabolism	14	70	0.6000671591672263	0.971951987287384
Lipid particle organization	0	1	0.0	1.0
Rac1 gtpase cycle	38	152	0.8000451365380276	0.900352364140732
Inositol phosphate metabolism	5	40	0.3428667081161222	0.9967387252338186
Response of eif2ak1 hri to heme deficiency	3	10	1.031926587965397	0.5996338369181741
Defects of contact activation system cas and kallikrein kinin system kks	1	5	0.6018054162487463	0.8239879431862632
Constitutive signaling by ligand responsive egfr cancer variants	5	17	1.0032362459546926	0.5884307536605788
Regulation of gene expression by hypoxia inducible factor	0	5	0.0	1.0
Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects	3	17	0.515461453902404	0.9142722919386124
Adora2b mediated anti inflammatory cytokines production	8	30	0.8752132585912746	0.6920206151109443
Defective factor viii causes hemophilia a	0	3	0.0	1.0
Signaling by erbb2 in cancer	4	17	0.7405004633920297	0.7815360505152051
Anti inflammatory response favouring leishmania parasite infection	12	46	0.8491906829846032	0.7372175012589298
Signaling by erbb2	9	37	0.7732388295579714	0.8010744596285829
Fcgr3a mediated il10 synthesis	5	23	0.6682661905293308	0.8495505493646256
Fertilization	0	3	0.0	1.0
Killing mechanisms	1	9	0.3007355399531929	0.9561814898792792
Pexophagy	1	9	0.3007355399531929	0.9561814898792792
Signaling by erbb2 ecd mutants	4	15	0.8753803091152489	0.6838446456385155
Defective factor ix causes hemophilia b	1	3	1.2039451688398528	0.6473218534129999
Signaling by nodal	2	12	0.4812040133779264	0.9075099812904824
Signaling by kit in disease	3	18	0.4810304449648712	0.933024105996546
Signaling by pdgfr in disease	5	17	1.0032362459546926	0.5884307536605788
Defective f9 activation	0	1	0.0	1.0
Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants	3	11	0.9028103044496488	0.6702945765004975
Signaling by membrane tethered fusions of pdgfra or pdgfrb	0	3	0.0	1.0
Prolactin receptor signaling	3	9	1.2040816326530612	0.5196282464541333
Ras processing	5	19	0.8596776507723947	0.6966080955472779
Diseases of dna repair	10	33	1.0470066777476452	0.5174084723579307
N glycan trimming and elongation in the cis golgi	0	4	0.0	1.0
Cross presentation of particulate exogenous antigens phagosomes	0	3	0.0	1.0
Foxo mediated transcription of oxidative stress metabolic and neuronal genes	4	18	0.6875119525721936	0.8205132217227086
Late endosomal microautophagy	8	29	0.917017745435976	0.6507823648111599
Nuclear signaling by erbb4	3	18	0.4810304449648712	0.933024105996546
Transcriptional regulation of granulopoiesis	7	34	0.6233513245238539	0.9092825641979646
Negative regulation of nmda receptor mediated neuronal transmission	4	14	0.9630522088353414	0.624675255970463
Regulation of foxo transcriptional activity by acetylation	1	10	0.2672833314759092	0.969051322224564
Foxo mediated transcription of cell cycle genes	0	13	0.0	1.0
Activation of rac1 downstream of nmdars	1	6	0.4813774657305249	0.8756637428026797
Activation of ampk downstream of nmdars	6	21	0.9630274614869392	0.6124722534016208
Egr2 and sox10 mediated initiation of schwann cell myelination	5	20	0.8022542126994755	0.7426880917621369
Nr1h2 nr1h3 regulate gene expression to control bile acid homeostasis	0	6	0.0	1.0
Nr1h2 nr1h3 regulate gene expression linked to gluconeogenesis	0	4	0.0	1.0
Shc1 events in erbb4 signaling	1	6	0.4813774657305249	0.8756637428026797
Constitutive signaling by overexpressed erbb2	3	11	0.9028103044496488	0.6702945765004975
Estrogen stimulated signaling through prkcz	1	6	0.4813774657305249	0.8756637428026797
Estrogen dependent nuclear events downstream of esr membrane signaling	4	15	0.8753803091152489	0.6838446456385155
Pi3k events in erbb4 signaling	0	2	0.0	1.0
Shc1 events in erbb2 signaling	1	13	0.2003789145213418	0.9890984267926946
Erythrocytes take up oxygen and release carbon dioxide	0	1	0.0	1.0
Modulation by mtb of host immune system	0	4	0.0	1.0
Erythrocytes take up carbon dioxide and release oxygen	1	4	0.8025186671124485	0.7508451551458319
Amino acids regulate mtorc1	11	45	0.778163663989581	0.8112816386108553
Alpha protein kinase 1 signaling pathway	1	9	0.3007355399531929	0.9561814898792792
Signaling by erbb4	6	36	0.480509042196919	0.9740608669684238
Sars cov 1 infection	12	42	0.9629530201342282	0.6016972857464967
Activation of ras in b cells	0	3	0.0	1.0
Translation of replicase and assembly of the replication transcription complex	3	13	0.7220475075276012	0.7830437973449951
Heme signaling	5	36	0.3873235633983822	0.9912317422080796
Regulation of bach1 activity	3	10	1.031926587965397	0.5996338369181741
Sensory perception	23	84	0.9071277517958798	0.6931337875578348
Apoptotic factor mediated response	4	20	0.6014056224899599	0.8812712129159418
Smac xiap regulated apoptotic response	1	8	0.3437455222811291	0.9379623427931464
Cytochrome c mediated apoptotic response	3	13	0.7220475075276012	0.7830437973449951
Activation of caspases through apoptosome mediated cleavage	0	6	0.0	1.0
Sensory perception of taste	0	4	0.0	1.0
Formation of apoptosome	3	11	0.9028103044496488	0.6702945765004975
Release of apoptotic factors from the mitochondria	1	6	0.4813774657305249	0.8756637428026797
Traf6 mediated irf7 activation in tlr7 8 or 9 signaling	1	10	0.2672833314759092	0.969051322224564
N glycan antennae elongation in the medial trans golgi	2	15	0.3700025726781579	0.9606307441557927
N glycan antennae elongation	0	8	0.0	1.0
Reactions specific to the complex n glycan synthesis pathway	2	6	1.2040133779264215	0.5656089450744413
Termination of o glycan biosynthesis	0	4	0.0	1.0
Amyloid fiber formation	6	41	0.4115778394412018	0.9914840119915252
Serine biosynthesis	2	7	0.963076923076923	0.6566171786481523
Gaba receptor activation	4	18	0.6875119525721936	0.8205132217227086
Gaba b receptor activation	4	16	0.8023203926818384	0.7360995100844776
Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members	1	8	0.3437455222811291	0.9379623427931464
Activation of noxa and translocation to mitochondria	1	5	0.6018054162487463	0.8239879431862632
Recognition and association of dna glycosylase with site containing an affected purine	4	16	0.8023203926818384	0.7360995100844776
Antigen activates b cell receptor bcr leading to generation of second messengers	2	20	0.2670382757339279	0.9911014099285992
Opioid signalling	17	63	0.8891925465838509	0.7045952903528545
Pka mediated phosphorylation of creb	3	13	0.7220475075276012	0.7830437973449951
Camk iv mediated phosphorylation of creb	2	8	0.8024526198439242	0.7316356285104274
Flt3 signaling by cbl mutants	1	4	0.8025186671124485	0.7508451551458319
Gpvi mediated activation cascade	5	21	0.7520087043856712	0.7833805412598392
Maturation of sars cov 1 nucleoprotein	2	9	0.6877209746774964	0.7922091662556401
Maturation of protein 3a	1	5	0.6018054162487463	0.8239879431862632
Effects of pip2 hydrolysis	3	17	0.515461453902404	0.9142722919386124
Transcriptional regulation of testis differentiation	0	4	0.0	1.0
Defective ripk1 mediated regulated necrosis	1	6	0.4813774657305249	0.8756637428026797
Sos mediated signalling	1	7	0.401092165385044	0.9121715035098086
Mapk1 erk2 activation	2	7	0.963076923076923	0.6566171786481523
Attachment and entry	1	4	0.8025186671124485	0.7508451551458319
Irs mediated signalling	4	26	0.4370208105147864	0.9697599170039232
Neuronal system	48	177	0.894211324570273	0.7686030767969322
Foxo mediated transcription of cell death genes	0	12	0.0	1.0
Transmission across chemical synapses	37	139	0.8718157990776683	0.7881227078684553
Neurotransmitter release cycle	5	30	0.4806829594911282	0.9645851332924128
Presynaptic depolarization and calcium channel opening	0	4	0.0	1.0
Electric transmission across gap junctions	0	2	0.0	1.0
G protein mediated events	10	40	0.8019226469930695	0.7788895119119675
Stat5 activation downstream of flt3 itd mutants	2	6	1.2040133779264215	0.5656089450744413
Signaling by flt3 fusion proteins	5	16	1.0945917156161549	0.5270800523063662
Signaling by flt3 itd and tkd mutants	2	12	0.4812040133779264	0.9075099812904824
Inactivation of csf3 g csf signaling	5	17	1.0032362459546926	0.5884307536605788
Ca dependent events	6	26	0.721768251841929	0.8195103866850959
Negative regulation of flt3	2	8	0.8024526198439242	0.7316356285104274
Flt3 signaling through src family kinases	0	2	0.0	1.0
Neurotransmitter receptors and postsynaptic signal transmission	31	105	1.008744306616647	0.5209858326822338
Downregulation of erbb4 signaling	1	7	0.401092165385044	0.9121715035098086
Foxo mediated transcription	11	47	0.7347273472734728	0.8555667342928327
Interleukin 7 signaling	2	13	0.4373973852234721	0.9301401965681808
Extracellular matrix organization	26	131	0.5926660886876666	0.9951283128108788
Degradation of the extracellular matrix	6	56	0.2875016744809109	0.9997912086677236
Alpha defensins	0	1	0.0	1.0
Notch3 activation and transmission of signal to the nucleus	3	18	0.4810304449648712	0.933024105996546
Notch3 intracellular domain regulates transcription	3	18	0.4810304449648712	0.933024105996546
Defensins	0	1	0.0	1.0
Notch4 intracellular domain regulates transcription	1	15	0.1717055929693843	0.9945637612889204
Notch4 activation and transmission of signal to the nucleus	2	8	0.8024526198439242	0.7316356285104274
Tlr3 mediated ticam1 dependent programmed cell death	1	5	0.6018054162487463	0.8239879431862632
Ticam1 dependent activation of irf3 irf7	0	10	0.0	1.0
Ticam1 traf6 dependent induction of tak1 complex	1	10	0.2672833314759092	0.969051322224564
Interleukin 36 pathway	0	1	0.0	1.0
Noncanonical activation of notch3	2	8	0.8024526198439242	0.7316356285104274
Collagen degradation	0	21	0.0	1.0
Regulation of signaling by nodal	0	3	0.0	1.0
Biosynthesis of epa derived spms	1	3	1.2039451688398528	0.6473218534129999
Interleukin 2 signaling	0	5	0.0	1.0
Regulation of kit signaling	2	12	0.4812040133779264	0.9075099812904824
Signaling by scf kit	6	31	0.5770127260549229	0.9276030862003526
Loss of mecp2 binding ability to the ncor smrt complex	1	7	0.401092165385044	0.9121715035098086
Regulation of mecp2 expression and activity	9	30	1.0319908050380728	0.537377176470804
Formation of fibrin clot clotting cascade	2	9	0.6877209746774964	0.7922091662556401
Common pathway of fibrin clot formation	0	5	0.0	1.0
Collagen formation	13	44	1.009745638826625	0.5452897721452463
Reversible hydration of carbon dioxide	0	2	0.0	1.0
Acyl chain remodelling of pc	1	9	0.3007355399531929	0.9561814898792792
Acyl chain remodelling of ps	1	9	0.3007355399531929	0.9561814898792792
Metabolism of cofactors	4	15	0.8753803091152489	0.6838446456385155
Triglyceride metabolism	6	20	1.031958664242656	0.5583681068930001
Synthesis of pe	2	12	0.4812040133779264	0.9075099812904824
Interleukin 15 signaling	2	8	0.8024526198439242	0.7316356285104274
Interleukin 35 signalling	3	9	1.2040816326530612	0.5196282464541333
Transcriptional regulation by mecp2	13	45	0.9780547163477676	0.5829215706476896
Signaling by ntrk2 trkb	5	18	0.9259354639334552	0.6451159513320872
Signaling by erythropoietin	3	19	0.4509033121445299	0.9479246404767652
Synthesis of pc	5	22	0.7076744323440792	0.8188911287130645
Synthesis of pa	7	25	0.9361995160990136	0.6329105152499283
Synthesis of pg	2	8	0.8024526198439242	0.7316356285104274
Mecp2 regulates transcription factors	1	4	0.8025186671124485	0.7508451551458319
Signaling by tgfb family members	20	79	0.8149508406140931	0.8187609460323371
Extra nuclear estrogen signaling	12	47	0.8248130393096836	0.765806154020295
Er quality control compartment erqc	2	18	0.3005016722408026	0.9837457247494442
Calnexin calreticulin cycle	7	23	1.0535175879396983	0.5326719776995769
Hydrolysis of lpc	1	3	1.2039451688398528	0.6473218534129999
Robo receptors bind akap5	2	8	0.8024526198439242	0.7316356285104274
Signaling by notch3	6	35	0.4971476083793334	0.96790448615865
Acyl chain remodelling of pg	2	7	0.963076923076923	0.6566171786481523
Acyl chain remodelling of pi	1	4	0.8025186671124485	0.7508451551458319
Cdc42 gtpase cycle	28	134	0.6325719960278053	0.9898866116721688
Acyl chain remodeling of dag and tag	0	2	0.0	1.0
Acyl chain remodelling of pe	0	8	0.0	1.0
Interleukin 37 signaling	2	12	0.4812040133779264	0.9075099812904824
G beta gamma signalling through cdc42	3	14	0.6563155813741294	0.8262352177182655
Nr1h2 and nr1h3 mediated signaling	5	31	0.4621307718060312	0.9716970654300356
Erythropoietin activates phosphoinositide 3 kinase pi3k	0	8	0.0	1.0
Traf6 mediated irf7 activation	2	15	0.3700025726781579	0.9606307441557927
Traf6 mediated nf kb activation	5	22	0.7076744323440792	0.8188911287130645
Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10	4	13	1.0702067529376766	0.5588754825262198
Negative regulators of ddx58 ifih1 signaling	6	29	0.6273624741547511	0.894060359590428
Ion transport by p type atpases	9	31	0.984944991314418	0.5827692698138716
Activation of irf3 irf7 mediated by tbk1 ikk epsilon	1	11	0.2405215646940822	0.9781420785502122
Irak1 recruits ikk complex	2	12	0.4812040133779264	0.9075099812904824
Ikk complex recruitment mediated by rip1	3	16	0.5551895411380189	0.8908482493424653
Irak2 mediated activation of tak1 complex	1	9	0.3007355399531929	0.9561814898792792
Traf6 mediated induction of tak1 complex within tlr4 complex	1	11	0.2405215646940822	0.9781420785502122
Molybdenum cofactor biosynthesis	2	7	0.963076923076923	0.6566171786481523
Transcription of e2f targets under negative control by dream complex	3	19	0.4509033121445299	0.9479246404767652
Activated ntrk3 signals through pi3k	0	4	0.0	1.0
Downregulation of erbb2 erbb3 signaling	1	10	0.2672833314759092	0.969051322224564
Grb7 events in erbb2 signaling	0	2	0.0	1.0
Diseases of base excision repair	0	4	0.0	1.0
Flt3 signaling	5	27	0.5464588976473811	0.9322710956586476
Acrosome reaction and sperm oocyte membrane binding	0	1	0.0	1.0
Sperm motility and taxes	0	1	0.0	1.0
Tandem pore domain potassium channels	0	2	0.0	1.0
Voltage gated potassium channels	0	2	0.0	1.0
Potassium channels	1	15	0.1717055929693843	0.9945637612889204
Inwardly rectifying k channels	1	12	0.2186255736907692	0.9845631783003476
Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1	2	16	0.3435260391782131	0.9705996719890696
Traf3 dependent irf activation pathway	2	13	0.4373973852234721	0.9301401965681808
Rora activates gene expression	3	17	0.515461453902404	0.9142722919386124
Bmal1 clock npas2 activates circadian gene expression	3	20	0.4243205478912876	0.9596870100427658
Erythropoietin activates phospholipase c gamma plcg	1	5	0.6018054162487463	0.8239879431862632
Erythropoietin activates stat5	0	4	0.0	1.0
Erythropoietin activates ras	2	11	0.5347454477889261	0.8781437590361336
Activated ntrk2 signals through pi3k	1	4	0.8025186671124485	0.7508451551458319
Activated ntrk2 signals through frs2 and frs3	2	7	0.963076923076923	0.6566171786481523
Nr1h2 nr1h3 regulate gene expression linked to lipogenesis	2	7	0.963076923076923	0.6566171786481523
Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux	3	26	0.313366401442972	0.9919433614038574
Nr1h2 nr1h3 regulate gene expression to limit cholesterol uptake	0	3	0.0	1.0
Nr1h2 nr1h3 regulate gene expression linked to triglyceride lipolysis in adipose	0	3	0.0	1.0
Ngf stimulated transcription	3	22	0.3795495765174059	0.9761225818261172
Activated ntrk2 signals through fyn	1	4	0.8025186671124485	0.7508451551458319
Activated ntrk2 signals through ras	1	6	0.4813774657305249	0.8756637428026797
Ntrk2 activates rac1	1	3	1.2039451688398528	0.6473218534129999
Extrinsic pathway of fibrin clot formation	0	1	0.0	1.0
Caspase activation via death receptors in the presence of ligand	2	11	0.5347454477889261	0.8781437590361336
Blood group systems biosynthesis	0	5	0.0	1.0
Signaling by ntrk3 trkc	3	15	0.6015389762462362	0.8618328607283439
Activated ntrk3 signals through ras	1	6	0.4813774657305249	0.8756637428026797
Activation of puma and translocation to mitochondria	1	8	0.3437455222811291	0.9379623427931464
Elevation of cytosolic ca2 levels	0	6	0.0	1.0
Interleukin receptor shc signaling	1	14	0.1849394336856724	0.9923015601562292
Regulation of signaling by cbl	4	18	0.6875119525721936	0.8205132217227086
Abc transporters in lipid homeostasis	2	7	0.963076923076923	0.6566171786481523
O linked glycosylation of mucins	3	22	0.3795495765174059	0.9761225818261172
Intrinsic pathway of fibrin clot formation	2	7	0.963076923076923	0.6566171786481523
Synthesis of pyrophosphates in the cytosol	1	10	0.2672833314759092	0.969051322224564
Pre notch processing in golgi	3	13	0.7220475075276012	0.7830437973449951
Rna polymerase iii chain elongation	5	19	0.8596776507723947	0.6966080955472779
Interleukin 2 family signaling	3	21	0.4006914241106278	0.9689174597054394
Transcriptional regulation of pluripotent stem cells	1	16	0.1602362643486013	0.9961613672451204
Scavenging by class a receptors	3	10	1.031926587965397	0.5996338369181741
Scavenging by class b receptors	1	2	2.4082246740220663	0.5008051893494083
Ecm proteoglycans	2	37	0.1370090778786431	0.9999580704399798
Thrombin signalling through proteinase activated receptors pars	4	21	0.56595007480904	0.9043043121411438
Non integrin membrane ecm interactions	4	37	0.2909009776479656	0.9982235301865416
Syndecan interactions	4	20	0.6014056224899599	0.8812712129159418
Laminin interactions	1	23	0.1091456186742044	0.999664397240253
Peptide hormone metabolism	13	43	1.0435492894707397	0.5065548172238039
Notch2 activation and transmission of signal to the nucleus	1	16	0.1602362643486013	0.9961613672451204
Disassembly of the destruction complex and recruitment of axin to the membrane	6	24	0.8021879883902657	0.7499274740177471
Regulation of fzd by ubiquitination	0	9	0.0	1.0
Repression of wnt target genes	3	13	0.7220475075276012	0.7830437973449951
Sumoylation of dna methylation proteins	1	16	0.1602362643486013	0.9961613672451204
Sumoylation of immune response proteins	0	10	0.0	1.0
Pou5f1 oct4 sox2 nanog activate genes related to proliferation	1	8	0.3437455222811291	0.9379623427931464
Pou5f1 oct4 sox2 nanog repress genes related to differentiation	0	6	0.0	1.0
Presynaptic function of kainate receptors	1	13	0.2003789145213418	0.9890984267926946
Gpcr ligand binding	9	46	0.5844198204238432	0.952503243291925
Defective galnt3 causes hftc	0	1	0.0	1.0
Defective lfng causes scdo3	0	3	0.0	1.0
Defective c1galt1c1 causes tnps	0	2	0.0	1.0
Ionotropic activity of kainate receptors	1	3	1.2039451688398528	0.6473218534129999
Fceri mediated ca 2 mobilization	4	20	0.6014056224899599	0.8812712129159418
Sumo is transferred from e1 to e2 ube2i ubc9	2	7	0.963076923076923	0.6566171786481523
Dex h box helicases activate type i ifn and inflammatory cytokines production	2	7	0.963076923076923	0.6566171786481523
Type i hemidesmosome assembly	2	9	0.6877209746774964	0.7922091662556401
Synthesis of dolichyl phosphate	1	5	0.6018054162487463	0.8239879431862632
Trp channels	1	7	0.401092165385044	0.9121715035098086
Chromatin modifying enzymes	58	210	0.917142037096832	0.7341111273810481
Sumoylation of transcription factors	3	18	0.4810304449648712	0.933024105996546
Glycogen storage diseases	3	10	1.031926587965397	0.5996338369181741
Regulation of cytoskeletal remodeling and cell spreading by ipp complex components	2	7	0.963076923076923	0.6566171786481523
Processing and activation of sumo	2	10	0.6016722408026756	0.8403529985689939
Cell junction organization	16	54	1.0138653084323712	0.5331286709490815
Nrcam interactions	1	7	0.401092165385044	0.9121715035098086
Chl1 interactions	2	7	0.963076923076923	0.6566171786481523
Neurofascin interactions	1	6	0.4813774657305249	0.8756637428026797
Hats acetylate histones	18	90	0.5995292535305985	0.9837137935800414
Interleukin 17 signaling	16	57	0.9392866509310256	0.6329578989953143
Interleukin 1 processing	0	3	0.0	1.0
Hdms demethylate histones	5	25	0.6012721794442585	0.8979888857555822
Other interleukin signaling	2	12	0.4812040133779264	0.9075099812904824
Pkmts methylate histone lysines	12	46	0.8491906829846032	0.7372175012589298
Activated tak1 mediates p38 mapk activation	3	20	0.4243205478912876	0.9596870100427658
Jnk c jun kinases phosphorylation and activation mediated by activated human tak1	2	18	0.3005016722408026	0.9837457247494442
Hdacs deacetylate histones	12	40	1.0320230105465005	0.5233766293220338
Regulation of innate immune responses to cytosolic dna	3	11	0.9028103044496488	0.6702945765004975
Lrr flii interacting protein 1 lrrfip1 activates type i ifn production	1	5	0.6018054162487463	0.8239879431862632
Sumo is proteolytically processed	0	6	0.0	1.0
Interleukin 3 interleukin 5 and gm csf signaling	7	31	0.7015633724176438	0.8481020736427258
Fceri mediated mapk activation	7	24	0.99140802049463	0.5842864352535018
O linked glycosylation	3	35	0.2249498159919705	0.9993895721065365
Release of hh np from the secreting cell	0	2	0.0	1.0
Ra biosynthesis pathway	3	9	1.2040816326530612	0.5196282464541333
Negative regulation of tcf dependent signaling by dvl interacting proteins	0	5	0.0	1.0
The canonical retinoid cycle in rods twilight vision	1	4	0.8025186671124485	0.7508451551458319
Retinoid cycle disease events	0	2	0.0	1.0
Organic cation transport	0	3	0.0	1.0
Organic cation anion zwitterion transport	0	3	0.0	1.0
Shc related events triggered by igf1r	1	7	0.401092165385044	0.9121715035098086
Phase 4 resting membrane potential	0	2	0.0	1.0
Phase 3 rapid repolarisation	0	1	0.0	1.0
Cardiac conduction	10	43	0.7287157287157288	0.8530791174053061
Phase 0 rapid depolarisation	1	6	0.4813774657305249	0.8756637428026797
Phase 2 plateau phase	0	3	0.0	1.0
Dap12 signaling	3	19	0.4509033121445299	0.9479246404767652
Physiological factors	0	6	0.0	1.0
Metabolism of ingested semet sec mesec into h2se	1	4	0.8025186671124485	0.7508451551458319
Ikba variant leads to eda id	1	7	0.401092165385044	0.9121715035098086
Irak4 deficiency tlr2 4	1	4	0.8025186671124485	0.7508451551458319
Signaling by type 1 insulin like growth factor 1 receptor igf1r	5	29	0.50078116281665	0.9558569099906208
Clec7a dectin 1 induces nfat activation	2	10	0.6016722408026756	0.8403529985689939
Crosslinking of collagen fibrils	0	10	0.0	1.0
Constitutive signaling by aberrant pi3k in cancer	6	32	0.5547426451646144	0.940560165972986
Pi3k akt signaling in cancer	12	58	0.6266121972570762	0.94897036667539
Activation of the phototransduction cascade	0	2	0.0	1.0
The phototransduction cascade	3	12	0.8023865283818445	0.7313126477609548
Interaction with cumulus cells and the zona pellucida	0	1	0.0	1.0
Oxidative stress induced senescence	10	69	0.4061089702054132	0.9988154383810152
O glycosylation of tsr domain containing proteins	0	5	0.0	1.0
Role of lat2 ntal lab on calcium mobilization	1	12	0.2186255736907692	0.9845631783003476
Signaling by notch1 hd domain mutants in cancer	0	9	0.0	1.0
Uptake and function of anthrax toxins	2	10	0.6016722408026756	0.8403529985689939
Stimuli sensing channels	9	38	0.7464713838186505	0.8273697555402955
Signaling by notch1 t 7 9 notch1 m1580 k2555 translocation mutant	0	4	0.0	1.0
Acetylcholine neurotransmitter release cycle	0	11	0.0	1.0
Vegfr2 mediated cell proliferation	2	15	0.3700025726781579	0.9606307441557927
Signaling by notch1 pest domain mutants in cancer	6	45	0.3691586377453759	0.996678906410292
Signaling by leptin	2	8	0.8024526198439242	0.7316356285104274
Toxicity of botulinum toxin type d botd	0	3	0.0	1.0
Tak1 activates nfkb by phosphorylation and activation of ikks complex	5	25	0.6012721794442585	0.8979888857555822
Myogenesis	6	22	0.9027126590756864	0.6626445438959574
Trif mediated programmed cell death	1	4	0.8025186671124485	0.7508451551458319
Dna methylation	4	14	0.9630522088353414	0.624675255970463
Oncogene induced senescence	6	30	0.601138647019424	0.9122157934436538
Uptake and actions of bacterial toxins	6	23	0.8494937157716402	0.7085172143039323
Signaling by lrp5 mutants	0	2	0.0	1.0
Signaling by rnf43 mutants	0	4	0.0	1.0
Caspase activation via extrinsic apoptotic signalling pathway	2	18	0.3005016722408026	0.9837457247494442
Tnfr1 induced proapoptotic signaling	1	13	0.2003789145213418	0.9890984267926946
Cellular senescence	35	131	0.8763809040694397	0.7750523950312892
Regulation of tnfr1 signaling	3	31	0.2572288868709076	0.9980416138790038
Tnfr1 induced nfkappab signaling pathway	4	28	0.4004908522980812	0.9814592752917354
Diseases of immune system	2	15	0.3700025726781579	0.9606307441557927
Aquaporin mediated transport	5	26	0.5725604604077988	0.9166742426731276
Defects in cobalamin b12 metabolism	3	10	1.031926587965397	0.5996338369181741
Loss of function of smad2 3 in cancer	0	7	0.0	1.0
Circadian clock	10	55	0.5334972799761533	0.9798097469951248
Free fatty acids regulate insulin secretion	2	8	0.8024526198439242	0.7316356285104274
Incretin synthesis secretion and inactivation	4	14	0.9630522088353414	0.624675255970463
Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip	3	9	1.2040816326530612	0.5196282464541333
Diseases associated with n glycosylation of proteins	4	18	0.6875119525721936	0.8205132217227086
Sialic acid metabolism	4	16	0.8023203926818384	0.7360995100844776
Negative regulation of tcf dependent signaling by wnt ligand antagonists	0	5	0.0	1.0
Ca2 pathway	4	45	0.2338786038462794	0.9998083129639072
Deactivation of the beta catenin transactivating complex	9	36	0.8019890490557604	0.771897309757236
Sumoylation of intracellular receptors	0	18	0.0	1.0
G alpha q signalling events	11	66	0.4796377054679637	0.994247139201834
G alpha 12 13 signalling events	7	57	0.3355309882747068	0.9993820666408272
Dscam interactions	3	9	1.2040816326530612	0.5196282464541333
Other semaphorin interactions	1	7	0.401092165385044	0.9121715035098086
Ncam signaling for neurite out growth	6	34	0.5149746435747775	0.9604315162740188
P2y receptors	0	1	0.0	1.0
Nucleotide like purinergic receptors	0	1	0.0	1.0
Platelet homeostasis	9	51	0.5144868540778699	0.9811721113644608
Platelet calcium homeostasis	3	13	0.7220475075276012	0.7830437973449951
Cgmp effects	0	7	0.0	1.0
G alpha s signalling events	5	37	0.3751673920321393	0.993125914934019
Adp signalling through p2y purinoceptor 1	2	17	0.3205797101449275	0.9781099893195382
G alpha i signalling events	22	88	0.8011223344556678	0.8455379481791604
Regulation of lipid metabolism by pparalpha	18	95	0.5602057659892226	0.9926290581272
Adrenaline noradrenaline inhibits insulin secretion	3	16	0.5551895411380189	0.8908482493424653
Acetylcholine regulates insulin secretion	1	8	0.3437455222811291	0.9379623427931464
Diseases of glycosylation	16	76	0.6401433691756272	0.9609405900706504
Ctla4 inhibitory signaling	5	17	1.0032362459546926	0.5884307536605788
Receptor type tyrosine protein phosphatases	1	11	0.2405215646940822	0.9781420785502122
Nuclear receptor transcription pathway	2	29	0.1778025517155952	0.99945679911164
Sumoylation of transcription cofactors	8	41	0.5825818506783654	0.9453701614550212
Olfactory signaling pathway	0	2	0.0	1.0
Glucagon like peptide 1 glp1 regulates insulin secretion	5	27	0.5464588976473811	0.9322710956586476
Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps	15	56	0.8802854404089893	0.7103675739760634
Transcriptional regulation of white adipocyte differentiation	10	68	0.4131686671754666	0.9985285836115836
Atf6 atf6 alpha activates chaperone genes	2	6	1.2040133779264215	0.5656089450744413
Diseases associated with o glycosylation of proteins	1	17	0.1502006018054162	0.9972895783561956
Atf6 atf6 alpha activates chaperones	2	8	0.8024526198439242	0.7316356285104274
G alpha z signalling events	4	28	0.4004908522980812	0.9814592752917354
Signal regulatory protein family interactions	3	9	1.2040816326530612	0.5196282464541333
Nitric oxide stimulates guanylate cyclase	0	11	0.0	1.0
Adp signalling through p2y purinoceptor 12	4	13	1.0702067529376766	0.5588754825262198
G beta gamma signalling through pi3kgamma	3	15	0.6015389762462362	0.8618328607283439
Rap1 signalling	3	13	0.7220475075276012	0.7830437973449951
Prostacyclin signalling through prostacyclin receptor	1	12	0.2186255736907692	0.9845631783003476
Chemokine receptors bind chemokines	0	3	0.0	1.0
Ephrin signaling	4	17	0.7405004633920297	0.7815360505152051
Eph ephrin mediated repulsion of cells	11	43	0.8270295202952029	0.7576100485909272
G protein beta gamma signalling	5	22	0.7076744323440792	0.8188911287130645
Dopamine clearance from the synaptic cleft	1	2	2.4082246740220663	0.5008051893494083
Sema3a plexin repulsion signaling by inhibiting integrin adhesion	2	10	0.6016722408026756	0.8403529985689939
Energy dependent regulation of mtor by lkb1 ampk	5	27	0.5464588976473811	0.9322710956586476
Anchoring fibril formation	0	8	0.0	1.0
Dcc mediated attractive signaling	2	13	0.4373973852234721	0.9301401965681808
Caspase activation via dependence receptors in the absence of ligand	0	7	0.0	1.0
Defective chsy1 causes tpbs	0	4	0.0	1.0
Defective chst14 causes eds musculocontractural type	1	4	0.8025186671124485	0.7508451551458319
Defective chst3 causes sedcjd	0	4	0.0	1.0
Gp1b ix v activation signalling	2	7	0.963076923076923	0.6566171786481523
Vasopressin regulates renal water homeostasis via aquaporins	4	25	0.4578950723529036	0.9615928901875648
Defective b4galt7 causes eds progeroid type	0	13	0.0	1.0
Diseases associated with glycosaminoglycan metabolism	4	26	0.4370208105147864	0.9697599170039232
Fatty acids bound to gpr40 ffar1 regulate insulin secretion	0	6	0.0	1.0
Zinc transporters	0	12	0.0	1.0
Zinc efflux and compartmentalization by the slc30 family	0	5	0.0	1.0
Grb2 sos provides linkage to mapk signaling for integrins	2	9	0.6877209746774964	0.7922091662556401
Integrin signaling	5	18	0.9259354639334552	0.6451159513320872
Binding of tcf lef ctnnb1 to target gene promoters	1	7	0.401092165385044	0.9121715035098086
Amino acid transport across the plasma membrane	3	17	0.515461453902404	0.9142722919386124
Zinc influx into cells by the slc39 gene family	0	7	0.0	1.0
Na cl dependent neurotransmitter transporters	0	4	0.0	1.0
Creb1 phosphorylation through the activation of adenylate cyclase	3	9	1.2040816326530612	0.5196282464541333
Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde	2	7	0.963076923076923	0.6566171786481523
Notch hlh transcription pathway	3	21	0.4006914241106278	0.9689174597054394
Activation of nmda receptors and postsynaptic events	20	68	1.003252579632122	0.5411079819896368
Ras activation upon ca2 influx through nmda receptor	4	13	1.0702067529376766	0.5588754825262198
Regulation by c flip	2	10	0.6016722408026756	0.8403529985689939
Signaling by tgf beta receptor complex in cancer	1	8	0.3437455222811291	0.9379623427931464
Defective chst6 causes mcdc1	0	1	0.0	1.0
Thromboxane signalling through tp receptor	3	15	0.6015389762462362	0.8618328607283439
Defective ext2 causes exostoses 2	0	11	0.0	1.0
Defective b4galt1 causes b4galt1 cdg cdg 2d	0	1	0.0	1.0
Role of second messengers in netrin 1 signaling	1	3	1.2039451688398528	0.6473218534129999
Ncam1 interactions	0	15	0.0	1.0
Lysosphingolipid and lpa receptors	0	3	0.0	1.0
Tight junction interactions	1	11	0.2405215646940822	0.9781420785502122
Glucagon type ligand receptors	1	13	0.2003789145213418	0.9890984267926946
Nectin necl trans heterodimerization	0	5	0.0	1.0
Cell cell junction organization	7	31	0.7015633724176438	0.8481020736427258
Netrin 1 signaling	8	33	0.7698659517426274	0.7960496689507663
Regulation of insulin secretion	12	48	0.8017897091722596	0.792170947596045
Transport of bile salts and organic acids metal ions and amine compounds	2	32	0.1599554069119286	0.999790784454271
Bicarbonate transporters	1	4	0.8025186671124485	0.7508451551458319
Netrin mediated repulsion signals	1	5	0.6018054162487463	0.8239879431862632
Transport of inorganic cations anions and amino acids oligopeptides	9	44	0.6179876442699105	0.9328378360580994
Metal ion slc transporters	0	15	0.0	1.0
Sodium calcium exchangers	1	3	1.2039451688398528	0.6473218534129999
Sodium proton exchangers	0	4	0.0	1.0
Class b 2 secretin family receptors	2	25	0.2088410644176239	0.998090749402456
Cation coupled chloride cotransporters	1	4	0.8025186671124485	0.7508451551458319
Sirt1 negatively regulates rrna expression	4	18	0.6875119525721936	0.8205132217227086
Signaling by gpcr	41	204	0.6001521788392413	0.9990649647357662
Multifunctional anion exchangers	0	3	0.0	1.0
Sodium coupled phosphate cotransporters	0	2	0.0	1.0
P130cas linkage to mapk signaling for integrins	2	9	0.6877209746774964	0.7922091662556401
Regulation of commissural axon pathfinding by slit and robo	1	7	0.401092165385044	0.9121715035098086
Slc mediated transmembrane transport	19	101	0.5550687898402697	0.994486575933628
Synthesis of ip2 ip and ins in the cytosol	2	12	0.4812040133779264	0.9075099812904824
Activation of anterior hox genes in hindbrain development during early embryogenesis	14	60	0.7315385289222414	0.8803171144778819
Visual phototransduction	5	40	0.3428667081161222	0.9967387252338186
Tp53 regulates transcription of genes involved in g1 cell cycle arrest	2	13	0.4373973852234721	0.9301401965681808
Formation of the beta catenin tcf transactivating complex	10	38	0.8594423684966944	0.7163451728683593
Wnt mediated activation of dvl	2	8	0.8024526198439242	0.7316356285104274
Regulation of tp53 activity through association with co factors	2	12	0.4812040133779264	0.9075099812904824
Regulation of tp53 activity through methylation	4	16	0.8023203926818384	0.7360995100844776
Keratinization	5	24	0.6330061846950822	0.8757671481753739
Regulation of tp53 expression and degradation	9	33	0.9026148172980222	0.6667162820541698
Metabolism of fat soluble vitamins	3	29	0.277092930488715	0.9965295982974371
Signaling by met	19	64	1.016713383413686	0.5232847807123222
Met receptor activation	1	4	0.8025186671124485	0.7508451551458319
Signaling by alk	5	19	0.8596776507723947	0.6966080955472779
Signaling by bmp	1	15	0.1717055929693843	0.9945637612889204
Creb phosphorylation	2	7	0.963076923076923	0.6566171786481523
Formation of the cornified envelope	5	24	0.6330061846950822	0.8757671481753739
Negative regulation of the pi3k akt network	13	62	0.6372156113200568	0.948412681686518
Vitamin b5 pantothenate metabolism	4	13	1.0702067529376766	0.5588754825262198
Intra golgi traffic	10	42	0.7515928906773978	0.8308770083779342
Retrograde transport at the trans golgi network	13	49	0.8688970944761478	0.7176802734896238
Immunoregulatory interactions between a lymphoid and a non lymphoid cell	6	26	0.721768251841929	0.8195103866850959
Pi5p regulates tp53 acetylation	3	9	1.2040816326530612	0.5196282464541333
Akt phosphorylates targets in the nucleus	1	9	0.3007355399531929	0.9561814898792792
Cdc6 association with the orc origin complex	3	12	0.8023865283818445	0.7313126477609548
Pi3k akt activation	1	7	0.401092165385044	0.9121715035098086
G protein activation	1	13	0.2003789145213418	0.9890984267926946
Signaling by notch2	1	22	0.1143589498654694	0.9995245861479584
Assembly of collagen fibrils and other multimeric structures	2	28	0.1846668381785438	0.9992549231781572
Tp53 regulates transcription of caspase activators and caspases	1	8	0.3437455222811291	0.9379623427931464
Synthesis of wybutosine at g37 of trna phe	0	6	0.0	1.0
Fanconi anemia pathway	6	36	0.480509042196919	0.9740608669684238
Interleukin 10 signaling	1	6	0.4813774657305249	0.8756637428026797
Calcineurin activates nfat	2	8	0.8024526198439242	0.7316356285104274
Erbb2 regulates cell motility	2	6	1.2040133779264215	0.5656089450744413
Interleukin 4 and interleukin 13 signaling	12	40	1.0320230105465005	0.5233766293220338
Cs ds degradation	2	7	0.963076923076923	0.6566171786481523
Gdp fucose biosynthesis	1	6	0.4813774657305249	0.8756637428026797
Il 6 type cytokine receptor ligand interactions	0	6	0.0	1.0
Hs gag degradation	3	17	0.515461453902404	0.9142722919386124
Rrna modification in the mitochondrion	1	6	0.4813774657305249	0.8756637428026797
Protein protein interactions at synapses	14	46	1.053643384822028	0.4908860254433825
Hs gag biosynthesis	1	17	0.1502006018054162	0.9972895783561956
Choline catabolism	1	4	0.8025186671124485	0.7508451551458319
Dermatan sulfate biosynthesis	1	6	0.4813774657305249	0.8756637428026797
Chondroitin sulfate biosynthesis	0	12	0.0	1.0
Signaling by moderate kinase activity braf mutants	11	36	1.059630996309963	0.4992096541396956
Keratan sulfate biosynthesis	1	11	0.2405215646940822	0.9781420785502122
Ras signaling downstream of nf1 loss of function variants	0	5	0.0	1.0
Metabolism of angiotensinogen to angiotensins	0	8	0.0	1.0
Antimicrobial peptides	2	7	0.963076923076923	0.6566171786481523
Tp53 regulates transcription of genes involved in cytochrome c release	1	16	0.1602362643486013	0.9961613672451204
Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain	2	11	0.5347454477889261	0.8781437590361336
Tp53 regulates transcription of death receptors and ligands	2	10	0.6016722408026756	0.8403529985689939
Signaling by notch1	7	56	0.3424264178033022	0.9992112952789172
Nicotinamide salvaging	3	11	0.9028103044496488	0.6702945765004975
G2 phase	1	4	0.8025186671124485	0.7508451551458319
Tryptophan catabolism	2	6	1.2040133779264215	0.5656089450744413
Creatine metabolism	2	6	1.2040133779264215	0.5656089450744413
Fgfr2b ligand binding and activation	0	2	0.0	1.0
Fgfr2c ligand binding and activation	0	2	0.0	1.0
Fgfr1c ligand binding and activation	0	2	0.0	1.0
Fgfr3b ligand binding and activation	0	1	0.0	1.0
Fgfr1b ligand binding and activation	0	2	0.0	1.0
Fgfr1 ligand binding and activation	0	2	0.0	1.0
Fgfr2 ligand binding and activation	0	2	0.0	1.0
Fgfr3 ligand binding and activation	0	3	0.0	1.0
Mrna editing c to u conversion	0	2	0.0	1.0
Cellular hexose transport	1	6	0.4813774657305249	0.8756637428026797
Signalling to p38 via rit and rin	0	3	0.0	1.0
Signalling to erks	9	30	1.0319908050380728	0.537377176470804
Ngf independant trka activation	0	1	0.0	1.0
Activation of trka receptors	0	1	0.0	1.0
Signaling by pdgf	7	35	0.6010050251256281	0.9243121618016044
Downstream signal transduction	7	23	1.0535175879396983	0.5326719776995769
Regulation of beta cell development	3	22	0.3795495765174059	0.9761225818261172
Transport of nucleotide sugars	1	4	0.8025186671124485	0.7508451551458319
Pyrimidine salvage	2	9	0.6877209746774964	0.7922091662556401
Pyrimidine catabolism	1	6	0.4813774657305249	0.8756637428026797
Synthesis of ip3 and ip4 in the cytosol	2	20	0.2670382757339279	0.9911014099285992
Histidine catabolism	0	3	0.0	1.0
Pre notch processing in the endoplasmic reticulum	1	5	0.6018054162487463	0.8239879431862632
Urea cycle	2	6	1.2040133779264215	0.5656089450744413
Fructose catabolism	0	3	0.0	1.0
A tetrasaccharide linker sequence is required for gag synthesis	1	16	0.1602362643486013	0.9961613672451204
Vitamin b2 riboflavin metabolism	1	4	0.8025186671124485	0.7508451551458319
Vitamin b1 thiamin metabolism	1	5	0.6018054162487463	0.8239879431862632
Nicotinate metabolism	4	18	0.6875119525721936	0.8205132217227086
Coenzyme a biosynthesis	2	8	0.8024526198439242	0.7316356285104274
Cobalamin cbl vitamin b12 transport and metabolism	3	13	0.7220475075276012	0.7830437973449951
Pi3k events in erbb2 signaling	1	7	0.401092165385044	0.9121715035098086
Cyclin d associated events in g1	9	45	0.600737512571237	0.9434173720287172
Grb2 events in erbb2 signaling	1	7	0.401092165385044	0.9121715035098086
Vegf ligand receptor interactions	0	2	0.0	1.0
Signaling by vegf	26	87	1.0264859666382942	0.4964037976560833
Trna modification in the nucleus and cytosol	11	43	0.8270295202952029	0.7576100485909272
Bile acid and bile salt metabolism	5	22	0.7076744323440792	0.8188911287130645
Synthesis of bile acids and bile salts via 24 hydroxycholesterol	0	5	0.0	1.0
P75 ntr receptor mediated signalling	12	81	0.4163991829588561	0.9993098273391524
Regulated proteolysis of p75ntr	1	11	0.2405215646940822	0.9781420785502122
Nrage signals death through jnk	5	47	0.2854432700432031	0.9994697994334536
P75ntr signals via nf kb	0	14	0.0	1.0
Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol	3	13	0.7220475075276012	0.7830437973449951
Estrogen biosynthesis	1	2	2.4082246740220663	0.5008051893494083
Androgen biosynthesis	1	2	2.4082246740220663	0.5008051893494083
Synthesis of bile acids and bile salts	5	20	0.8022542126994755	0.7426880917621369
Pre notch expression and processing	9	50	0.527108901662265	0.9772014129056082
Cd28 dependent pi3k akt signaling	2	15	0.3700025726781579	0.9606307441557927
Synthesis of bile acids and bile salts via 27 hydroxycholesterol	0	7	0.0	1.0
Cell surface interactions at the vascular wall	14	70	0.6000671591672263	0.971951987287384
Signaling by hippo	6	21	0.9630274614869392	0.6124722534016208
Fcgr activation	0	5	0.0	1.0
Phospholipase c mediated cascade fgfr4	1	3	1.2039451688398528	0.6473218534129999
Downstream signaling of activated fgfr1	3	15	0.6015389762462362	0.8618328607283439
Shc mediated cascade fgfr1	1	8	0.3437455222811291	0.9379623427931464
Pi 3k cascade fgfr1	2	8	0.8024526198439242	0.7316356285104274
Frs mediated fgfr1 signaling	2	9	0.6877209746774964	0.7922091662556401
Pi 3k cascade fgfr2	2	8	0.8024526198439242	0.7316356285104274
Downstream signaling of activated fgfr2	3	14	0.6563155813741294	0.8262352177182655
Frs mediated fgfr2 signaling	2	9	0.6877209746774964	0.7922091662556401
Shc mediated cascade fgfr3	1	8	0.3437455222811291	0.9379623427931464
Frs mediated fgfr3 signaling	2	9	0.6877209746774964	0.7922091662556401
Downstream signaling of activated fgfr3	3	14	0.6563155813741294	0.8262352177182655
Pi 3k cascade fgfr3	2	8	0.8024526198439242	0.7316356285104274
Frs mediated fgfr4 signaling	2	9	0.6877209746774964	0.7922091662556401
Downstream signaling of activated fgfr4	3	14	0.6563155813741294	0.8262352177182655
Shc mediated cascade fgfr4	1	8	0.3437455222811291	0.9379623427931464
Pi 3k cascade fgfr4	2	8	0.8024526198439242	0.7316356285104274
Signaling by fgfr1	7	28	0.8021217197096594	0.7573372587936686
Ubiquinol biosynthesis	0	7	0.0	1.0
Signaling by fgfr3	7	27	0.8423450586264657	0.7196284267594591
Signaling by fgfr4	7	26	0.8868024332187252	0.6781129016609558
Synthesis of 15 eicosatetraenoic acid derivatives	0	3	0.0	1.0
Signaling by fgfr4 in disease	2	11	0.5347454477889261	0.8781437590361336
Synthesis of 12 eicosatetraenoic acid derivatives	0	2	0.0	1.0
Phospholipase c mediated cascade fgfr2	1	3	1.2039451688398528	0.6473218534129999
Synthesis of 16 20 hydroxyeicosatetraenoic acids hete	0	1	0.0	1.0
Hyaluronan biosynthesis and export	0	1	0.0	1.0
Gli proteins bind promoters of hh responsive genes to promote transcription	0	2	0.0	1.0
The retinoid cycle in cones daylight vision	0	1	0.0	1.0
Egfr transactivation by gastrin	1	7	0.401092165385044	0.9121715035098086
Smad2 smad3 smad4 heterotrimer regulates transcription	4	29	0.3844176706827309	0.9855556537572402
Downregulation of smad2 3 smad4 transcriptional activity	5	23	0.6682661905293308	0.8495505493646256
Transcriptional activity of smad2 smad3 smad4 heterotrimer	8	41	0.5825818506783654	0.9453701614550212
Tgf beta receptor signaling in emt epithelial to mesenchymal transition	3	14	0.6563155813741294	0.8262352177182655
Intraflagellar transport	12	48	0.8017897091722596	0.792170947596045
Pyroptosis	4	16	0.8023203926818384	0.7360995100844776
Dectin 2 family	0	4	0.0	1.0
Cd209 dc sign signaling	3	18	0.4810304449648712	0.933024105996546
Downregulation of tgf beta receptor signaling	6	22	0.9027126590756864	0.6626445438959574
Synthesis of 5 eicosatetraenoic acids	1	3	1.2039451688398528	0.6473218534129999
Dap12 interactions	5	21	0.7520087043856712	0.7833805412598392
Scavenging of heme from plasma	0	2	0.0	1.0
Abacavir metabolism	1	4	0.8025186671124485	0.7508451551458319
Abacavir transport and metabolism	2	6	1.2040133779264215	0.5656089450744413
Tnfr1 mediated ceramide production	1	3	1.2039451688398528	0.6473218534129999
Abacavir transmembrane transport	1	2	2.4082246740220663	0.5008051893494083
Integrin cell surface interactions	4	37	0.2909009776479656	0.9982235301865416
Activation of ppargc1a pgc 1alpha by phosphorylation	2	8	0.8024526198439242	0.7316356285104274
Ligand receptor interactions	0	2	0.0	1.0
Transcriptional activation of mitochondrial biogenesis	12	51	0.7398038203407331	0.8582578855024988
Tp53 regulates transcription of cell death genes	3	34	0.2322386384485047	0.9991810491268044
Activation of smo	2	11	0.5347454477889261	0.8781437590361336
Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3	4	14	0.9630522088353414	0.624675255970463
Notch2 intracellular domain regulates transcription	0	7	0.0	1.0
Fgfrl1 modulation of fgfr1 signaling	0	2	0.0	1.0
Clec7a inflammasome pathway	0	4	0.0	1.0
Regulation of gene expression in early pancreatic precursor cells	1	3	1.2039451688398528	0.6473218534129999
Ovarian tumor domain proteases	8	34	0.7401526087853165	0.8241602173122456
Cd22 mediated bcr regulation	0	2	0.0	1.0
Regulation of gene expression in beta cells	2	12	0.4812040133779264	0.9075099812904824
Resolution of d loop structures	7	32	0.6734070351758794	0.8714557404830116
Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells	1	10	0.2672833314759092	0.969051322224564
Glutamate neurotransmitter release cycle	2	17	0.3205797101449275	0.9781099893195382
Resolution of d loop structures through synthesis dependent strand annealing sdsa	7	26	0.8868024332187252	0.6781129016609558
Metabolism of amine derived hormones	0	1	0.0	1.0
Nf kb is activated and signals survival	0	11	0.0	1.0
P75ntr recruits signalling complexes	0	11	0.0	1.0
Nrif signals cell death from the nucleus	1	14	0.1849394336856724	0.9923015601562292
Nade modulates death signalling	1	5	0.6018054162487463	0.8239879431862632
Cell death signalling via nrage nrif and nade	7	63	0.2993299832495812	0.999862139910286
Linoleic acid la metabolism	2	7	0.963076923076923	0.6566171786481523
Nostrin mediated enos trafficking	1	3	1.2039451688398528	0.6473218534129999
Yap1 and wwtr1 taz stimulated gene expression	0	10	0.0	1.0
Deposition of new cenpa containing nucleosomes at the centromere	7	34	0.6233513245238539	0.9092825641979646
Role of phospholipids in phagocytosis	3	16	0.5551895411380189	0.8908482493424653
Presynaptic nicotinic acetylcholine receptors	0	2	0.0	1.0
Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	0	1	0.0	1.0
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	0	2	0.0	1.0
Highly calcium permeable nicotinic acetylcholine receptors	0	2	0.0	1.0
Josephin domain dubs	2	9	0.6877209746774964	0.7922091662556401
Pecam1 interactions	2	9	0.6877209746774964	0.7922091662556401
Diseases associated with surfactant metabolism	0	1	0.0	1.0
Tie2 signaling	2	12	0.4812040133779264	0.9075099812904824
Metallothioneins bind metals	0	2	0.0	1.0
Molecules associated with elastic fibres	1	18	0.1413456054437823	0.9980862756412444
Egfr interacts with phospholipase c gamma	1	2	2.4082246740220663	0.5008051893494083
Dopamine neurotransmitter release cycle	1	18	0.1413456054437823	0.9980862756412444
Prc2 methylates histones and dna	4	23	0.5062354681885437	0.9388080659008848
Activated notch1 transmits signal to the nucleus	2	21	0.2529484245731385	0.9934365625959856
Rho gtpases activate rhotekin and rhophilins	1	8	0.3437455222811291	0.9379623427931464
Notch1 intracellular domain regulates transcription	5	39	0.3530002560113432	0.9958082107547568
Cyp2e1 reactions	0	1	0.0	1.0
Tnfs bind their physiological receptors	0	1	0.0	1.0
Raf activation	9	33	0.9026148172980222	0.6667162820541698
Response to metal ions	0	5	0.0	1.0
Constitutive signaling by akt1 e17k in cancer	6	25	0.7598618112595622	0.786880197836483
Negative regulation of mapk pathway	10	36	0.925811277923954	0.6433955278603966
Tnf receptor superfamily tnfsf members mediating non canonical nf kb pathway	0	5	0.0	1.0
Protein repair	1	5	0.6018054162487463	0.8239879431862632
Eicosanoids	0	1	0.0	1.0
Lgi adam interactions	1	5	0.6018054162487463	0.8239879431862632
Endogenous sterols	2	12	0.4812040133779264	0.9075099812904824
Surfactant metabolism	1	8	0.3437455222811291	0.9379623427931464
Map3k8 tpl2 dependent mapk1 3 activation	4	14	0.9630522088353414	0.624675255970463
Miscellaneous substrates	0	2	0.0	1.0
Cytochrome p450 arranged by substrate type	3	15	0.6015389762462362	0.8618328607283439
Regulation of tlr by endogenous ligand	1	3	1.2039451688398528	0.6473218534129999
Xenobiotics	0	4	0.0	1.0
Activation of kainate receptors upon glutamate binding	2	16	0.3435260391782131	0.9705996719890696