Term overlap geneset_size odds pval fdr leading_edge Metabolism of rna 453 647 6.446912697993771 1.0642296941296079e-108 1.6687121603952253e-105 A5YKK6,O00148,O00231,O00232,O00267,O00425,O00487,O00541,O00566,O00567,O14744,O14818,O14980,O15042,O15091,O15213,O15504,O15514,O43143,O43148,O43172,O43242,O43290,O43390,O43395,O43447,O43592,O43660,O43709,O43809,O43818,O60231,O60306,O60508,O60828,O60832,O75152,O75400,O75494,O75533,O75643,O75648,O75691,O75694,O75832,O75934,O75937,O75940,O94906,O95400,O95453,P04792,P05387,P05388,P06730,P07814,P07910,P08579,P08621,P08708,P08865,P09012,P09234,P09651,P09661,P11142,P11940,P12270,P14866,P15170,P15880,P16383,P17844,P17980,P18074,P18077,P18124,P18621,P19338,P19387,P19388,P19447,P20618,P22087,P22626,P23396,P23588,P24928,P25398,P25786,P25787,P25788,P25789,P26196,P26368,P26373,P26599,P27635,P28066,P28070,P28072,P28074,P30050,P30153,P30876,P31943,P31946,P32969,P33240,P35268,P35269,P35637,P35658,P35998,P36578,P37198,P38159,P38919,P39019,P39023,P39687,P40429,P41223,P42285,P42766,P43686,P46087,P46776,P46777,P46778,P46779,P46781,P46782,P46783,P47914,P48556,P49207,P49720,P49721,P49790,P49792,P50914,P51003,P51665,P51991,P52272,P52597,P52756,P52948,P54105,P55036,P55265,P55769,P55795,P56182,P57678,P57740,P60842,P60866,P60900,P61247,P61254,P61289,P61313,P61353,P61513,P61927,P61978,P62081,P62191,P62195,P62241,P62244,P62249,P62263,P62266,P62269,P62277,P62280,P62304,P62312,P62314,P62316,P62318,P62333,P62424,P62487,P62495,P62701,P62750,P62753,P62826,P62829,P62841,P62847,P62851,P62857,P62861,P62875,P62888,P62899,P62906,P62910,P62913,P62917,P62995,P63104,P63151,P63173,P63220,P67809,P78316,P78346,P78406,P82979,P83731,P83881,P84098,P84103,Q00839,Q01081,Q01105,Q01780,Q02543,Q02878,Q04637,Q05048,Q05519,Q06265,Q06323,Q07020,Q07955,Q08170,Q08211,Q08J23,Q09161,Q10570,Q12769,Q12788,Q12874,Q12996,Q13151,Q13200,Q13242,Q13243,Q13247,Q13435,Q13573,Q13601,Q13769,Q13838,Q13868,Q13895,Q14103,Q14137,Q14240,Q14690,Q14692,Q14997,Q15007,Q15008,Q15024,Q15029,Q15061,Q15269,Q15287,Q15365,Q15366,Q15393,Q15427,Q15428,Q15459,Q15477,Q15637,Q15717,Q16539,Q16629,Q16637,Q2NL82,Q52LJ0,Q53GS9,Q5KU26,Q5RKV6,Q5SRE5,Q5SY16,Q5VV42,Q68CQ4,Q6P2E9,Q6P2Q9,Q6PGP7,Q6UN15,Q7L014,Q7L0Y3,Q7RTV0,Q7Z3B4,Q7Z4G4,Q86TB9,Q86U42,Q86V81,Q86W42,Q86XP3,Q8IWA0,Q8IWX8,Q8IWZ8,Q8IX12,Q8IY37,Q8IY81,Q8IYB3,Q8IZL8,Q8N1F7,Q8N684,Q8NFH3,Q8NFH4,Q8NFH5,Q8NI27,Q8NI36,Q8TED0,Q8TEM1,Q8TEQ6,Q8WUA2,Q8WUM0,Q8WVM0,Q8WWY3,Q8WYA6,Q92499,Q92530,Q92600,Q92620,Q92621,Q92733,Q92797,Q92900,Q92917,Q92945,Q92973,Q92979,Q969T7,Q969X6,Q969Y2,Q96B26,Q96BP3,Q96C86,Q96DI7,Q96EE3,Q96F86,Q96FV9,Q96G21,Q96GA3,Q96I25,Q96J01,Q96PZ0,Q99436,Q99459,Q99460,Q99567,Q99575,Q99714,Q99848,Q9BQ52,Q9BQA1,Q9BTX1,Q9BUJ2,Q9BUQ8,Q9BV38,Q9BVC5,Q9BVI4,Q9BVJ6,Q9BVL2,Q9BVP2,Q9BW27,Q9BXP5,Q9BY77,Q9BZI7,Q9BZJ0,Q9C0C2,Q9C0J8,Q9GZL7,Q9GZS3,Q9H074,Q9H0A0,Q9H0D6,Q9H0S4,Q9H4L4,Q9H583,Q9H6R4,Q9H814,Q9H8H0,Q9H974,Q9HAU5,Q9HBH5,Q9HCS7,Q9NPD3,Q9NPF4,Q9NQT4,Q9NQT5,Q9NQZ2,Q9NR30,Q9NRG9,Q9NRX1,Q9NV06,Q9NV31,Q9NW13,Q9NW64,Q9NX24,Q9NX74,Q9NXF1,Q9NXG2,Q9NY12,Q9NY93,Q9NYH9,Q9NZI8,Q9P013,Q9P2I0,Q9UBB9,Q9UBU9,Q9UHI6,Q9UHX1,Q9UIV1,Q9UJA5,Q9UK45,Q9UKF6,Q9UKX7,Q9UL46,Q9ULX3,Q9UMS4,Q9UNM6,Q9UNP9,Q9UNQ2,Q9UNX4,Q9UQ35,Q9Y221,Q9Y224,Q9Y2L1,Q9Y2P8,Q9Y2R4,Q9Y2W2,Q9Y2X3,Q9Y333,Q9Y3A2,Q9Y3B2,Q9Y3B4,Q9Y3C6,Q9Y3I0,Q9Y3U8,Q9Y3Y2,Q9Y450,Q9Y4W2,Q9Y4Z0,Q9Y5J1,Q9Y5S9,Q9Y606,Q9Y6M1,Q9Y6V7 Translation 215 289 7.459683305920252 5.678190929484905e-58 4.451701688716166e-55 O00303,O15371,O15372,O43324,O43776,O60841,O75616,O75821,O75822,O76094,P04843,P04844,P05198,P05387,P05388,P06730,P07814,P08240,P08708,P08865,P09001,P11940,P13639,P13798,P14868,P15170,P15880,P18077,P18124,P18621,P20042,P23381,P23396,P23588,P24534,P25398,P26373,P26639,P26640,P26641,P27635,P29692,P30050,P32969,P35268,P36578,P37108,P39019,P39023,P39656,P40429,P41250,P41252,P42766,P43307,P43897,P46776,P46777,P46778,P46779,P46781,P46782,P46783,P47897,P47914,P49207,P49406,P49411,P49458,P49588,P49589,P49591,P49770,P50914,P51398,P51571,P52815,P54136,P54577,P55010,P55884,P56192,P56537,P60228,P60468,P60842,P60866,P61009,P61011,P61247,P61254,P61313,P61353,P61513,P61619,P61927,P62081,P62241,P62244,P62249,P62263,P62266,P62269,P62277,P62280,P62424,P62495,P62701,P62750,P62753,P62829,P62841,P62847,P62851,P62857,P62861,P62888,P62899,P62906,P62910,P62913,P62917,P63173,P63220,P67812,P82650,P82663,P82673,P82675,P82912,P82914,P82930,P82933,P83731,P83881,P84098,Q02543,Q02878,Q04637,Q05639,Q07020,Q12904,Q13084,Q13144,Q13155,Q13347,Q13405,Q14152,Q14197,Q14232,Q14240,Q15005,Q15031,Q15046,Q15056,Q15070,Q15181,Q15629,Q5JPH6,Q5JTZ9,Q5ST30,Q5T160,Q6P1L8,Q6PI48,Q7L2H7,Q7Z2W9,Q7Z7H8,Q8N5N7,Q8N983,Q8TAE8,Q92552,Q92665,Q96A35,Q96DV4,Q96EL3,Q96EY7,Q96GC5,Q96GW9,Q96RP9,Q9BRJ2,Q9BW92,Q9BYC9,Q9BYD1,Q9BYD2,Q9BYD6,Q9BZE1,Q9H2U2,Q9H2W6,Q9H9J2,Q9HD33,Q9NP81,Q9NP92,Q9NQ50,Q9NR50,Q9NRX2,Q9NSD9,Q9NSE4,Q9NYK5,Q9P015,Q9P2J5,Q9UBQ5,Q9UHB9,Q9UI10,Q9Y262,Q9Y285,Q9Y2Q9,Q9Y2R5,Q9Y2R9,Q9Y2Z4,Q9Y399,Q9Y3B7,Q9Y3D3,Q9Y3D9,Q9Y3U8,Q9Y5M8 Processing of capped intron containing pre mrna 185 239 8.726530235258414 1.8273162596863113e-54 9.550772983960454e-52 O00148,O15042,O15504,O15514,O43143,O43172,O43290,O43390,O43395,O43447,O43660,O43809,O60231,O60306,O60508,O60828,O75152,O75400,O75494,O75533,O75643,O75694,O75934,O75937,O75940,O94906,O95400,P06730,P07910,P08579,P08621,P09012,P09234,P09651,P09661,P11142,P12270,P14866,P16383,P17844,P19387,P19388,P22626,P24928,P26368,P26599,P30876,P31943,P33240,P35269,P35637,P35658,P37198,P38159,P38919,P41223,P42285,P49790,P49792,P51003,P51991,P52272,P52597,P52756,P52948,P55769,P55795,P57740,P61978,P62304,P62312,P62314,P62316,P62318,P62487,P62875,P62995,P67809,P78406,P82979,P84103,Q00839,Q01081,Q05048,Q05519,Q07955,Q08170,Q08211,Q09161,Q10570,Q12769,Q12874,Q12996,Q13151,Q13242,Q13243,Q13247,Q13435,Q13573,Q13769,Q13838,Q14103,Q15007,Q15029,Q15287,Q15365,Q15366,Q15393,Q15427,Q15428,Q15459,Q15637,Q15717,Q16629,Q53GS9,Q5KU26,Q5SRE5,Q6P2Q9,Q6UN15,Q7L014,Q7RTV0,Q7Z3B4,Q86U42,Q86V81,Q86W42,Q86XP3,Q8IWX8,Q8IWZ8,Q8IX12,Q8IYB3,Q8N1F7,Q8N684,Q8NFH3,Q8NFH4,Q8NFH5,Q8NI27,Q8TEM1,Q8WUA2,Q8WUM0,Q8WWY3,Q8WYA6,Q92620,Q92621,Q92733,Q92797,Q92917,Q96BP3,Q96DI7,Q96EE3,Q96FV9,Q96I25,Q96J01,Q99459,Q99567,Q9BTX1,Q9BUJ2,Q9BUQ8,Q9BVL2,Q9BW27,Q9BXP5,Q9BY77,Q9BZI7,Q9BZJ0,Q9C0J8,Q9HCS7,Q9NRG9,Q9NW64,Q9P013,Q9P2I0,Q9UBB9,Q9UBU9,Q9UHX1,Q9UK45,Q9UKF6,Q9UKX7,Q9UMS4,Q9UNP9,Q9UQ35,Q9Y2W2,Q9Y333,Q9Y3B4,Q9Y3C6,Q9Y3Y2,Q9Y4Z0,Q9Y5S9 Rrna processing 161 202 9.935668685545917 1.415350462704678e-50 5.548173813802338e-48 O00425,O00541,O00566,O00567,O15091,O15213,O43709,O43818,O60832,O75691,P05387,P05388,P08708,P08865,P15880,P18077,P18124,P18621,P19338,P22087,P23396,P25398,P26373,P27635,P30050,P32969,P35268,P36578,P39019,P39023,P40429,P42285,P42766,P46087,P46776,P46777,P46778,P46779,P46781,P46782,P46783,P47914,P49207,P50914,P55769,P56182,P60866,P61247,P61254,P61313,P61353,P61513,P61927,P62081,P62241,P62244,P62249,P62263,P62266,P62269,P62277,P62280,P62424,P62701,P62750,P62753,P62829,P62841,P62847,P62851,P62857,P62861,P62888,P62899,P62906,P62910,P62913,P62917,P63173,P63220,P78316,P78346,P83731,P83881,P84098,Q01780,Q02543,Q02878,Q06265,Q07020,Q12788,Q13601,Q13868,Q13895,Q14137,Q14690,Q14692,Q15024,Q15061,Q15269,Q2NL82,Q5RKV6,Q5SY16,Q68CQ4,Q7L0Y3,Q8IWA0,Q8IY37,Q8IY81,Q8IZL8,Q8NI36,Q8TED0,Q8WVM0,Q92979,Q969X6,Q96B26,Q96G21,Q96GA3,Q99714,Q99848,Q9BQ52,Q9BV38,Q9BVI4,Q9BVJ6,Q9BVP2,Q9GZL7,Q9H0A0,Q9H0D6,Q9H0S4,Q9H4L4,Q9H583,Q9H6R4,Q9H8H0,Q9NPD3,Q9NQT4,Q9NQT5,Q9NQZ2,Q9NR30,Q9NRX1,Q9NV06,Q9NV31,Q9NW13,Q9NX24,Q9NXF1,Q9NXG2,Q9NY12,Q9NY93,Q9NYH9,Q9ULX3,Q9UNQ2,Q9UNX4,Q9Y221,Q9Y2L1,Q9Y2P8,Q9Y2R4,Q9Y2X3,Q9Y3A2,Q9Y3B2,Q9Y3U8,Q9Y4W2,Q9Y5J1,Q9Y6V7 Influenza infection 124 150 11.936380216714944 2.5051926469342024e-42 7.856284140785658e-40 O00410,O00505,O14980,O15504,O15514,O75694,P05387,P05388,P07900,P08708,P08865,P09496,P09874,P12236,P12270,P15880,P18077,P18124,P18621,P19387,P19388,P19525,P23396,P24928,P25398,P26373,P27635,P27797,P27824,P30050,P30876,P32969,P35268,P35269,P35658,P36578,P37198,P39019,P39023,P40429,P42766,P46776,P46777,P46778,P46779,P46781,P46782,P46783,P47914,P49207,P49790,P49792,P50914,P52292,P52294,P52948,P57740,P60866,P61247,P61254,P61313,P61353,P61513,P61927,P62081,P62241,P62244,P62249,P62263,P62266,P62269,P62277,P62280,P62424,P62487,P62701,P62750,P62753,P62826,P62829,P62841,P62847,P62851,P62857,P62861,P62875,P62888,P62899,P62906,P62910,P62913,P62917,P63173,P63220,P78406,P83731,P83881,P84098,Q00610,Q02543,Q02878,Q07020,Q12769,Q12849,Q13217,Q14974,Q5SRE5,Q7Z3B4,Q86U42,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7,Q9Y3U8 Mrna splicing 144 188 8.227783452502553 1.518887579711855e-41 3.969359541646981e-39 O15042,O15514,O43143,O43172,O43290,O43390,O43395,O43447,O43660,O43809,O60231,O60306,O60508,O60828,O75400,O75494,O75533,O75643,O75934,O75937,O75940,O94906,O95400,P07910,P08579,P08621,P09012,P09234,P09651,P09661,P11142,P14866,P16383,P17844,P19387,P19388,P22626,P24928,P26368,P26599,P30876,P31943,P33240,P35269,P35637,P38159,P38919,P41223,P42285,P51003,P51991,P52272,P52597,P52756,P55769,P55795,P61978,P62304,P62312,P62314,P62316,P62318,P62487,P62875,P62995,P67809,P84103,Q00839,Q01081,Q05048,Q05519,Q07955,Q08170,Q08211,Q09161,Q10570,Q12874,Q12996,Q13151,Q13242,Q13243,Q13247,Q13435,Q13573,Q14103,Q15029,Q15287,Q15365,Q15366,Q15393,Q15427,Q15428,Q15459,Q15637,Q15717,Q16629,Q53GS9,Q5KU26,Q6P2Q9,Q6UN15,Q7L014,Q7RTV0,Q86U42,Q86V81,Q86XP3,Q8IWX8,Q8IWZ8,Q8IX12,Q8IYB3,Q8N684,Q8WUA2,Q8WWY3,Q8WYA6,Q92620,Q92733,Q92797,Q92917,Q96BP3,Q96DI7,Q96I25,Q99459,Q9BUJ2,Q9BUQ8,Q9BXP5,Q9BZI7,Q9BZJ0,Q9C0J8,Q9HCS7,Q9NW64,Q9P013,Q9P2I0,Q9UBB9,Q9UHX1,Q9UK45,Q9UKF6,Q9UMS4,Q9UNP9,Q9UQ35,Q9Y2W2,Q9Y333,Q9Y3B4,Q9Y3C6,Q9Y4Z0,Q9Y5S9 Infectious disease 336 619 3.0938098684490614 6.480895505405898e-41 1.4517205932109214e-38 O00159,O00231,O00232,O00267,O00410,O00422,O00487,O00505,O14818,O14964,O14980,O15143,O15144,O15145,O15504,O15514,O43148,O43237,O43242,O43747,O43865,O60341,O60716,O60885,O75116,O75351,O75475,O75531,O75694,O75832,O94776,O94973,O95782,O95983,P00558,P04350,P04439,P04843,P04844,P04899,P05023,P05026,P05067,P05141,P05387,P05388,P05556,P06733,P06748,P07437,P07900,P08238,P08708,P08754,P08865,P09496,P09601,P09874,P10644,P12235,P12236,P12268,P12270,P12956,P13010,P13639,P13861,P14314,P15880,P17096,P17612,P17844,P17980,P18074,P18077,P18124,P18615,P18621,P18754,P18858,P19174,P19387,P19388,P19447,P19525,P20339,P20618,P20839,P21964,P22681,P23193,P23246,P23396,P24928,P25398,P25786,P25787,P25788,P25789,P26373,P27361,P27635,P27797,P27824,P28066,P28070,P28072,P28074,P28482,P29083,P30050,P30419,P30876,P32969,P35222,P35268,P35269,P35579,P35658,P35998,P36578,P37198,P39019,P39023,P39656,P39748,P40429,P42566,P42766,P43487,P43686,P46060,P46108,P46776,P46777,P46778,P46779,P46781,P46782,P46783,P46977,P47914,P48556,P48729,P49207,P49356,P49720,P49721,P49790,P49792,P49840,P49841,P50750,P50914,P51149,P51665,P52292,P52294,P52948,P53680,P54709,P55036,P55072,P57740,P59998,P60866,P60900,P60953,P61158,P61160,P61247,P61254,P61289,P61313,P61353,P61513,P61803,P61927,P61978,P62081,P62191,P62195,P62241,P62244,P62249,P62263,P62266,P62269,P62277,P62280,P62333,P62424,P62487,P62701,P62750,P62753,P62805,P62826,P62829,P62841,P62847,P62851,P62857,P62861,P62875,P62888,P62899,P62906,P62910,P62913,P62917,P62942,P62993,P63000,P63010,P63096,P63167,P63173,P63208,P63220,P68371,P78362,P78406,P83731,P83881,P83916,P84098,Q00403,Q00610,Q02543,Q02750,Q02790,Q02878,Q06323,Q07020,Q08945,Q09161,Q10472,Q10567,Q12769,Q12849,Q13177,Q13200,Q13217,Q13263,Q13330,Q13409,Q13464,Q13546,Q13547,Q13618,Q13724,Q13885,Q14204,Q14241,Q14697,Q14839,Q14974,Q14997,Q15008,Q15022,Q15185,Q15369,Q15370,Q16539,Q16706,Q16881,Q5SRE5,Q7L576,Q7Z3B4,Q86U42,Q86YP4,Q8IXH7,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q8WUM4,Q8WUX9,Q8WX92,Q8WXI9,Q92530,Q92621,Q92747,Q92769,Q92783,Q92804,Q93034,Q96CW1,Q96EE3,Q96F07,Q96FJ2,Q96JJ3,Q96SB4,Q99436,Q99460,Q99567,Q99570,Q99720,Q99816,Q99873,Q99961,Q9BRG1,Q9BTX1,Q9BUF5,Q9BVA1,Q9BVL2,Q9BW27,Q9BXS5,Q9H0U3,Q9H267,Q9H3P2,Q9H9H4,Q9NP79,Q9NRG9,Q9NWH9,Q9NZI8,Q9NZQ3,Q9NZZ3,Q9UBI6,Q9UI12,Q9UKL0,Q9UKX7,Q9UL46,Q9UN37,Q9UNM6,Q9UQB8,Q9UQN3,Q9Y2A7,Q9Y2Z0,Q9Y3E5,Q9Y3U8,Q9Y5B9,Q9Y6G9 Metabolism of amino acids and derivatives 188 281 5.126578006841226 9.21963286955706e-40 1.8070480424331838e-37 O00231,O00232,O00330,O00487,O14818,O15382,O43175,O43242,O43252,O43324,O43708,O75600,O75746,O75832,O94925,P00367,P00390,P00505,P04181,P05387,P05388,P07814,P08195,P08243,P08559,P08708,P08865,P09417,P09622,P10515,P11177,P11182,P12277,P12532,P14868,P15880,P16930,P17174,P17980,P18077,P18124,P18621,P19623,P20618,P23378,P23396,P23526,P24752,P25325,P25398,P25786,P25787,P25788,P25789,P26373,P26440,P27635,P28066,P28070,P28072,P28074,P30038,P30050,P30084,P31937,P32322,P32969,P34896,P35268,P35610,P35998,P36578,P36957,P39019,P39023,P40429,P41252,P42766,P43686,P45954,P46776,P46777,P46778,P46779,P46781,P46782,P46783,P47897,P47914,P48556,P49189,P49207,P49419,P49591,P49720,P49721,P50914,P51665,P52758,P52788,P54136,P54886,P55036,P56192,P57772,P60866,P60900,P61247,P61254,P61289,P61313,P61353,P61457,P61513,P61927,P62081,P62191,P62195,P62241,P62244,P62249,P62263,P62266,P62269,P62277,P62280,P62333,P62424,P62701,P62750,P62753,P62829,P62841,P62847,P62851,P62857,P62861,P62888,P62899,P62906,P62910,P62913,P62917,P63173,P63220,P78540,P83731,P83881,P84098,Q02218,Q02252,Q02543,Q02878,Q06323,Q07020,Q12904,Q13126,Q13155,Q13200,Q14997,Q15008,Q15046,Q16881,Q6NVY1,Q6YP21,Q7L266,Q92530,Q92947,Q96C36,Q96RQ3,Q99436,Q99460,Q99707,Q99714,Q9BQT8,Q9BV57,Q9HCC0,Q9NR77,Q9P2J5,Q9UBQ7,Q9UBX3,Q9UDR5,Q9UJS0,Q9UL46,Q9UNM6,Q9Y3U8,Q9Y617,Q9Y619 Eukaryotic translation initiation 100 116 15.534232365145229 1.4429487271592327e-37 2.513937337984085e-35 O00303,O15371,O15372,O60841,O75821,O75822,P05198,P05387,P05388,P06730,P08708,P08865,P11940,P15880,P18077,P18124,P18621,P20042,P23396,P23588,P25398,P26373,P27635,P30050,P32969,P35268,P36578,P39019,P39023,P40429,P42766,P46776,P46777,P46778,P46779,P46781,P46782,P46783,P47914,P49207,P49770,P50914,P55010,P55884,P56537,P60228,P60842,P60866,P61247,P61254,P61313,P61353,P61513,P61927,P62081,P62241,P62244,P62249,P62263,P62266,P62269,P62277,P62280,P62424,P62701,P62750,P62753,P62829,P62841,P62847,P62851,P62857,P62861,P62888,P62899,P62906,P62910,P62913,P62917,P63173,P63220,P83731,P83881,P84098,Q02543,Q02878,Q04637,Q07020,Q13144,Q13347,Q14152,Q14232,Q14240,Q15056,Q7L2H7,Q9NR50,Q9UBQ5,Q9UI10,Q9Y262,Q9Y3U8 Regulation of expression of slits and robos 122 155 9.237271671418013 1.7768320906545362e-37 2.786072718146313e-35 O00231,O00232,O00487,O14818,O43242,O75832,O94813,P05387,P05388,P08708,P08865,P11940,P15170,P15880,P17980,P18077,P18124,P18621,P20618,P23396,P25398,P25786,P25787,P25788,P25789,P26373,P27635,P28066,P28070,P28072,P28074,P30050,P32969,P35268,P35998,P36578,P38919,P39019,P39023,P40429,P42766,P43686,P46776,P46777,P46778,P46779,P46781,P46782,P46783,P47914,P48556,P49207,P49720,P49721,P50914,P51665,P55036,P60866,P60900,P61247,P61254,P61289,P61313,P61353,P61513,P61927,P62081,P62191,P62195,P62241,P62244,P62249,P62263,P62266,P62269,P62277,P62280,P62333,P62424,P62495,P62701,P62750,P62753,P62829,P62841,P62847,P62851,P62857,P62861,P62888,P62899,P62906,P62910,P62913,P62917,P63173,P63220,P83731,P83881,P84098,Q02543,Q02878,Q04637,Q06323,Q07020,Q09161,Q13200,Q13617,Q14997,Q15008,Q15287,Q15369,Q15370,Q92530,Q99436,Q99460,Q9BZI7,Q9HAU5,Q9UL46,Q9UNM6,Q9Y3U8,Q9Y5S9 Host interactions of hiv factors 95 116 11.216611601492513 5.164689810178104e-32 7.362030565781152e-30 O00231,O00232,O00487,O14818,O14980,O15504,O43242,O43747,O75475,O75531,O75694,O75832,O94973,O95782,P04439,P05141,P06748,P12235,P12236,P12270,P17096,P17980,P18754,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35658,P35998,P37198,P43487,P43686,P46060,P48556,P49720,P49721,P49790,P49792,P50750,P51665,P52294,P52948,P53680,P55036,P57740,P60900,P61289,P62191,P62195,P62333,P62826,P63000,P63010,P63208,P78406,Q06323,Q10567,Q12769,Q13177,Q13200,Q14974,Q14997,Q15008,Q15369,Q15370,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92530,Q92621,Q93034,Q96CW1,Q96EE3,Q99436,Q99460,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9BXS5,Q9NRG9,Q9UI12,Q9UKX7,Q9UL46,Q9UNM6 Cellular responses to stimuli 313 614 2.679433616202803 3.112927720716078e-31 4.067558888402342e-29 O00231,O00232,O00483,O00487,O14773,O14818,O14980,O15504,O43237,O43242,O43819,O60884,O60934,O75694,O75832,O75880,O75935,O76024,O94979,O95070,O95429,O95453,O95757,O95816,O95817,P00390,P00403,P02545,P04179,P04350,P04637,P04792,P05198,P05387,P05388,P07237,P07305,P07900,P08238,P08240,P08243,P08708,P08865,P09601,P09669,P0DMV9,P10412,P10606,P11142,P11802,P12270,P13073,P14625,P15880,P15927,P15954,P16104,P16402,P16403,P17096,P17980,P18077,P18124,P18621,P19784,P20042,P20618,P20674,P20700,P21281,P21283,P23396,P24941,P25398,P25685,P25786,P25787,P25788,P25789,P26373,P27361,P27635,P27694,P27797,P28066,P28070,P28072,P28074,P28482,P30041,P30044,P30048,P30050,P30260,P30519,P31689,P31948,P32119,P32969,P34932,P35244,P35268,P35611,P35658,P35998,P36543,P36578,P37198,P38606,P38646,P39019,P39023,P40429,P40763,P42345,P42704,P42766,P43307,P43686,P46776,P46777,P46778,P46779,P46781,P46782,P46783,P47755,P47756,P47914,P48556,P48723,P49207,P49720,P49721,P49748,P49790,P49792,P49840,P49841,P49959,P50454,P50914,P51665,P51812,P51858,P52907,P52948,P53004,P54652,P55036,P55072,P57740,P60866,P60900,P61163,P61247,P61254,P61289,P61313,P61353,P61421,P61513,P61927,P62081,P62191,P62195,P62241,P62244,P62249,P62258,P62263,P62266,P62269,P62277,P62280,P62333,P62424,P62701,P62750,P62753,P62805,P62829,P62841,P62847,P62851,P62857,P62861,P62888,P62899,P62906,P62910,P62913,P62917,P63167,P63173,P63208,P63220,P67870,P68371,P78406,P83731,P83881,P84098,Q00534,Q02543,Q02790,Q02878,Q06210,Q06265,Q06323,Q07020,Q0VDF9,Q12769,Q13200,Q13217,Q13309,Q13409,Q13451,Q13555,Q13561,Q13616,Q13617,Q13618,Q13868,Q13885,Q14203,Q14204,Q14997,Q15008,Q15022,Q15024,Q15084,Q15185,Q15369,Q15370,Q15418,Q15648,Q16539,Q16763,Q16881,Q5RKV6,Q5SRE5,Q6IAA8,Q7Z3B4,Q86X55,Q8N163,Q8N1F7,Q8N6T3,Q8NFH3,Q8NFH4,Q8NFH5,Q8TCT9,Q8TED1,Q8TEM1,Q8WUM0,Q92530,Q92598,Q92616,Q92621,Q92878,Q92945,Q969H8,Q96B26,Q96B36,Q96DE5,Q96EB6,Q96EE3,Q96FJ2,Q96HE7,Q96KQ7,Q96L91,Q96ST3,Q99436,Q99460,Q99543,Q99567,Q99615,Q9BTX1,Q9BUF5,Q9BVA1,Q9BVL2,Q9BW27,Q9H1A4,Q9HCE1,Q9HCU5,Q9NPD3,Q9NQT4,Q9NQT5,Q9NRG9,Q9NWM8,Q9NYB0,Q9NZ32,Q9UBS4,Q9UI12,Q9UJW0,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6,Q9UKX7,Q9UL15,Q9UL46,Q9UNM6,Q9Y2L1,Q9Y2Q5,Q9Y3B2,Q9Y3U8,Q9Y490,Q9Y4L1,Q9Y5K8,Q9Y5M8,Q9Y6G9 Srp dependent cotranslational protein targeting to membrane 89 108 11.593542070816035 1.838268201934637e-30 2.217234262025777e-28 O76094,P04843,P04844,P05387,P05388,P08240,P08708,P08865,P15880,P18077,P18124,P18621,P23396,P25398,P26373,P27635,P30050,P32969,P35268,P36578,P37108,P39019,P39023,P39656,P40429,P42766,P43307,P46776,P46777,P46778,P46779,P46781,P46782,P46783,P47914,P49207,P49458,P50914,P51571,P60468,P60866,P61009,P61011,P61247,P61254,P61313,P61353,P61513,P61619,P61927,P62081,P62241,P62244,P62249,P62263,P62266,P62269,P62277,P62280,P62424,P62701,P62750,P62753,P62829,P62841,P62847,P62851,P62857,P62861,P62888,P62899,P62906,P62910,P62913,P62917,P63173,P63220,P67812,P83731,P83881,P84098,Q02543,Q02878,Q07020,Q15005,Q15629,Q9UHB9,Q9Y3U8,Q9Y5M8 Signaling by robo receptors 135 197 5.443167319656306 2.0116836363556702e-30 2.2530856727183508e-28 O00231,O00232,O00487,O14818,O43242,O75122,O75832,O94813,P05387,P05388,P07737,P08708,P08865,P11940,P13861,P15170,P15880,P17612,P17980,P18077,P18124,P18621,P20618,P23396,P25398,P25786,P25787,P25788,P25789,P26373,P27635,P28066,P28070,P28072,P28074,P30050,P32969,P35080,P35268,P35998,P36578,P38919,P39019,P39023,P40429,P42766,P43686,P46776,P46777,P46778,P46779,P46781,P46782,P46783,P47914,P48556,P49207,P49720,P49721,P50914,P51665,P55036,P60866,P60900,P60953,P61247,P61254,P61289,P61313,P61353,P61513,P61586,P61927,P62081,P62191,P62195,P62241,P62244,P62249,P62263,P62266,P62269,P62277,P62280,P62333,P62424,P62495,P62701,P62750,P62753,P62829,P62841,P62847,P62851,P62857,P62861,P62888,P62899,P62906,P62910,P62913,P62917,P63000,P63173,P63220,P83731,P83881,P84098,Q01518,Q02543,Q02878,Q04637,Q06323,Q07020,Q09161,Q13177,Q13200,Q13617,Q14997,Q15008,Q15287,Q15369,Q15370,Q16512,Q7Z460,Q8N8S7,Q92530,Q99436,Q99460,Q9BZI7,Q9HAU5,Q9UL46,Q9UNM6,Q9Y3U8,Q9Y5S9 Selenoamino acid metabolism 88 107 11.45933014354067 5.268531171356453e-30 5.507371251124612e-28 O43252,O43324,P00390,P05387,P05388,P07814,P08708,P08865,P14868,P15880,P18077,P18124,P18621,P23396,P23526,P25398,P26373,P27635,P30050,P32969,P35268,P36578,P39019,P39023,P40429,P41252,P42766,P46776,P46777,P46778,P46779,P46781,P46782,P46783,P47897,P47914,P49207,P49591,P50914,P54136,P56192,P57772,P60866,P61247,P61254,P61313,P61353,P61513,P61927,P62081,P62241,P62244,P62249,P62263,P62266,P62269,P62277,P62280,P62424,P62701,P62750,P62753,P62829,P62841,P62847,P62851,P62857,P62861,P62888,P62899,P62906,P62910,P62913,P62917,P63173,P63220,P83731,P83881,P84098,Q02543,Q02878,Q07020,Q12904,Q13155,Q15046,Q16881,Q9P2J5,Q9Y3U8 Eukaryotic translation elongation 76 89 14.416904083570751 3.1277659000266676e-28 3.065210582026134e-26 P05387,P05388,P08708,P08865,P13639,P15880,P18077,P18124,P18621,P23396,P24534,P25398,P26373,P26641,P27635,P29692,P30050,P32969,P35268,P36578,P39019,P39023,P40429,P42766,P46776,P46777,P46778,P46779,P46781,P46782,P46783,P47914,P49207,P50914,P60866,P61247,P61254,P61313,P61353,P61513,P61927,P62081,P62241,P62244,P62249,P62263,P62266,P62269,P62277,P62280,P62424,P62701,P62750,P62753,P62829,P62841,P62847,P62851,P62857,P62861,P62888,P62899,P62906,P62910,P62913,P62917,P63173,P63220,P83731,P83881,P84098,Q02543,Q02878,Q05639,Q07020,Q9Y3U8 Cell cycle mitotic 253 498 2.6236701909679536 5.537097295979052e-25 5.107157976526561e-23 O00139,O00231,O00232,O00487,O14818,O14965,O14974,O14980,O15504,O43237,O43242,O43264,O43684,O43805,O43913,O60216,O60566,O60763,O75122,O75330,O75419,O75531,O75694,O75832,O75935,O94927,O95235,O95347,O95684,P00374,P02545,P04183,P04350,P04637,P04818,P06493,P07437,P07900,P08238,P09884,P11388,P11802,P12004,P12270,P14635,P15927,P16104,P17612,P17980,P18754,P18858,P19784,P20618,P20700,P24941,P25205,P25786,P25787,P25788,P25789,P27361,P27694,P28066,P28070,P28072,P28074,P28340,P28482,P30153,P30154,P30260,P31350,P31751,P33991,P33992,P33993,P35244,P35249,P35250,P35251,P35658,P35998,P37198,P39748,P40937,P40938,P41208,P41440,P42166,P42167,P42695,P43034,P43686,P46060,P48556,P49005,P49642,P49643,P49720,P49721,P49736,P49790,P49792,P49841,P50402,P50748,P51530,P51665,P52948,P53350,P53990,P55036,P57740,P60900,P61006,P61019,P61163,P61289,P61981,P62140,P62191,P62195,P62258,P62333,P62805,P62820,P62826,P63151,P63167,P63208,P67870,P68371,P78406,Q00534,Q01105,Q02241,Q06323,Q07864,Q08379,Q12769,Q13200,Q13257,Q13309,Q13409,Q13547,Q13561,Q13616,Q13885,Q14008,Q14181,Q14203,Q14204,Q14566,Q14683,Q14738,Q14739,Q14974,Q14980,Q14997,Q15003,Q15005,Q15008,Q15021,Q15154,Q15691,Q16763,Q29RF7,Q2NKX8,Q53HL2,Q5SRE5,Q68CZ6,Q6KC79,Q7L590,Q7Z3B4,Q7Z460,Q7Z4H7,Q7Z5K2,Q86XI2,Q86XL3,Q8IXJ6,Q8N1F7,Q8N3U4,Q8NBT2,Q8NC56,Q8NFH3,Q8NFH4,Q8NFH5,Q8TD19,Q8TEM1,Q8WUM0,Q8WUX9,Q8WVM7,Q8WYP5,Q92530,Q92621,Q92674,Q92973,Q96CS2,Q96CW5,Q96DE5,Q96EA4,Q96EE3,Q96FJ2,Q99436,Q99460,Q99567,Q99640,Q99661,Q99986,Q9BPX3,Q9BRT9,Q9BRX5,Q9BSJ2,Q9BTX1,Q9BUF5,Q9BVA1,Q9BVL2,Q9BW27,Q9BZD4,Q9H0U4,Q9H1A4,Q9H6D7,Q9H8Y8,Q9HBM1,Q9HC35,Q9NQS7,Q9NR33,Q9NRF9,Q9NRG9,Q9NTI5,Q9NTJ3,Q9P258,Q9UBD5,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6,Q9UKX7,Q9UL46,Q9ULW0,Q9UN37,Q9UNM6,Q9UQE7,Q9UQN3,Q9Y248,Q9Y266,Q9Y2S7,Q9Y2U8,Q9Y570,Q9Y619,Q9Y6G9,Q9Y6X3 Nonsense mediated decay nmd 84 110 7.974711670722675 1.6152110496327775e-24 1.4070282921245528e-22 P05387,P05388,P08708,P08865,P11940,P15170,P15880,P18077,P18124,P18621,P23396,P25398,P26373,P27635,P30050,P30153,P32969,P35268,P36578,P38919,P39019,P39023,P40429,P42766,P46776,P46777,P46778,P46779,P46781,P46782,P46783,P47914,P49207,P50914,P60866,P61247,P61254,P61313,P61353,P61513,P61927,P62081,P62241,P62244,P62249,P62263,P62266,P62269,P62277,P62280,P62424,P62495,P62701,P62750,P62753,P62829,P62841,P62847,P62851,P62857,P62861,P62888,P62899,P62906,P62910,P62913,P62917,P63151,P63173,P63220,P83731,P83881,P84098,Q02543,Q02878,Q04637,Q07020,Q09161,Q15287,Q92900,Q9BZI7,Q9HAU5,Q9Y3U8,Q9Y5S9 Response of eif2ak4 gcn2 to amino acid deficiency 75 94 9.722948956209516 3.729549380008359e-24 3.0778596988700566e-22 P05198,P05387,P05388,P08243,P08708,P08865,P15880,P18077,P18124,P18621,P20042,P23396,P25398,P26373,P27635,P30050,P32969,P35268,P36578,P39019,P39023,P40429,P42766,P46776,P46777,P46778,P46779,P46781,P46782,P46783,P47914,P49207,P50914,P60866,P61247,P61254,P61313,P61353,P61513,P61927,P62081,P62241,P62244,P62249,P62263,P62266,P62269,P62277,P62280,P62424,P62701,P62750,P62753,P62829,P62841,P62847,P62851,P62857,P62861,P62888,P62899,P62906,P62910,P62913,P62917,P63173,P63220,P83731,P83881,P84098,Q02543,Q02878,Q07020,Q92616,Q9Y3U8 Cell cycle 295 613 2.3685413329042517 3.946313326171371e-24 3.0939096477183547e-22 O00139,O00231,O00232,O00487,O00743,O14818,O14965,O14974,O14980,O15504,O15514,O43237,O43242,O43264,O43684,O43805,O43913,O60216,O60264,O60566,O60763,O60832,O60934,O75122,O75330,O75419,O75531,O75694,O75832,O75935,O94901,O94927,O95235,O95347,O95684,O96017,O96028,P00374,P02545,P04183,P04350,P04637,P04818,P06493,P06748,P07437,P07900,P08238,P09884,P11388,P11802,P12004,P12270,P14635,P15927,P16104,P17612,P17980,P18754,P18858,P19387,P19388,P19784,P20618,P20700,P24928,P24941,P25205,P25786,P25787,P25788,P25789,P27348,P27361,P27694,P28066,P28070,P28072,P28074,P28340,P28482,P30153,P30154,P30260,P30876,P31350,P31751,P31946,P33991,P33992,P33993,P35244,P35249,P35250,P35251,P35658,P35998,P37198,P38398,P39748,P40937,P40938,P41208,P41440,P42166,P42167,P42695,P43034,P43686,P46060,P48556,P49005,P49642,P49643,P49720,P49721,P49736,P49790,P49792,P49841,P49959,P50402,P50748,P51530,P51665,P52948,P53350,P53990,P54132,P54652,P55036,P57740,P60900,P61006,P61019,P61088,P61163,P61289,P61981,P62140,P62191,P62195,P62258,P62333,P62487,P62805,P62820,P62826,P62875,P63104,P63151,P63167,P63208,P67870,P68371,P78406,Q00534,Q01105,Q02241,Q04917,Q06323,Q07864,Q08379,Q12769,Q12888,Q13200,Q13257,Q13309,Q13409,Q13547,Q13561,Q13616,Q13885,Q14008,Q14181,Q14203,Q14204,Q14566,Q14676,Q14683,Q14738,Q14739,Q14974,Q14980,Q14997,Q15003,Q15005,Q15008,Q15021,Q15154,Q15691,Q16763,Q29RF7,Q2NKX8,Q53HL2,Q5H9R7,Q5SRE5,Q68CZ6,Q6KC79,Q7L590,Q7Z3B4,Q7Z460,Q7Z4H7,Q7Z5K2,Q86XI2,Q86XL3,Q8IXJ6,Q8N1F7,Q8N3U4,Q8NBT2,Q8NC56,Q8NFH3,Q8NFH4,Q8NFH5,Q8TD19,Q8TEM1,Q8WUM0,Q8WUX9,Q8WVB6,Q8WVM7,Q8WXH0,Q8WYP5,Q92530,Q92621,Q92674,Q92878,Q92973,Q96CS2,Q96CW5,Q96DE5,Q96EA4,Q96EE3,Q96FJ2,Q96T23,Q99436,Q99460,Q99567,Q99640,Q99661,Q99986,Q9BPX3,Q9BRT9,Q9BRX5,Q9BSJ2,Q9BTC0,Q9BTX1,Q9BUF5,Q9BVA1,Q9BVL2,Q9BW27,Q9BZD4,Q9H0U4,Q9H1A4,Q9H6D7,Q9H8Y8,Q9HBM1,Q9HC35,Q9NQS7,Q9NR33,Q9NRF9,Q9NRG9,Q9NTI5,Q9NTJ3,Q9NWV8,Q9NX24,Q9NXR7,Q9NY12,Q9NYB0,Q9P258,Q9UBD5,Q9UH99,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6,Q9UKX7,Q9UL46,Q9ULW0,Q9UN37,Q9UNM6,Q9UQ84,Q9UQE7,Q9UQN3,Q9Y230,Q9Y248,Q9Y265,Q9Y266,Q9Y2S7,Q9Y2U8,Q9Y3B8,Q9Y570,Q9Y619,Q9Y6G9,Q9Y6X3 Hiv infection 133 213 4.1425848198670865 4.916359227612837e-24 3.670881556617585e-22 O00231,O00232,O00267,O00487,O14818,O14980,O15504,O15514,O43148,O43242,O43747,O75351,O75475,O75531,O75694,O75832,O94973,O95782,P04439,P05141,P06748,P12235,P12236,P12270,P12956,P13010,P17096,P17980,P18074,P18615,P18754,P18858,P19387,P19388,P19447,P20618,P23193,P24928,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P29083,P30419,P30876,P35269,P35658,P35998,P37198,P39748,P43487,P43686,P46060,P48556,P49720,P49721,P49790,P49792,P50750,P51665,P52294,P52948,P53680,P55036,P57740,P60900,P61289,P62191,P62195,P62333,P62487,P62826,P62875,P63000,P63010,P63208,P78406,Q00403,Q06323,Q08945,Q09161,Q10567,Q12769,Q13177,Q13200,Q14241,Q14974,Q14997,Q15008,Q15369,Q15370,Q5SRE5,Q7Z3B4,Q8IXH7,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q8WUM4,Q8WUX9,Q8WX92,Q92530,Q92621,Q92804,Q93034,Q96CW1,Q96EE3,Q99436,Q99460,Q99567,Q99816,Q9BTX1,Q9BVL2,Q9BW27,Q9BXS5,Q9H3P2,Q9H9H4,Q9NP79,Q9NRG9,Q9NZZ3,Q9UI12,Q9UKX7,Q9UL46,Q9UN37,Q9UNM6,Q9UQN3,Q9Y5B9 M phase 192 355 2.9620333041191937 3.2917700536890523e-23 2.3461342928111065e-21 O00139,O00231,O00232,O00487,O14818,O14980,O15504,O43237,O43242,O43264,O43684,O43805,O60216,O60566,O60763,O75122,O75531,O75694,O75832,O75935,O94927,O95235,O95347,O95684,P02545,P04350,P06493,P07437,P07900,P12270,P14635,P16104,P17612,P17980,P18754,P19784,P20618,P20700,P25786,P25787,P25788,P25789,P27361,P28066,P28070,P28072,P28074,P28482,P30153,P30154,P30260,P35658,P35998,P37198,P41208,P42166,P42167,P42695,P43034,P43686,P46060,P48556,P49720,P49721,P49790,P49792,P50402,P50748,P51665,P52948,P53350,P53990,P55036,P57740,P60900,P61019,P61163,P61289,P61981,P62191,P62195,P62258,P62333,P62805,P62820,P62826,P63151,P63167,P67870,P68371,P78406,Q01105,Q02241,Q06323,Q08379,Q12769,Q13200,Q13257,Q13409,Q13561,Q13885,Q14008,Q14203,Q14204,Q14683,Q14738,Q14739,Q14974,Q14980,Q14997,Q15003,Q15005,Q15008,Q15021,Q15154,Q15691,Q16763,Q29RF7,Q2NKX8,Q53HL2,Q5SRE5,Q68CZ6,Q6KC79,Q7Z3B4,Q7Z460,Q7Z4H7,Q7Z5K2,Q86XI2,Q86XL3,Q8IXJ6,Q8N1F7,Q8N3U4,Q8NBT2,Q8NC56,Q8NFH3,Q8NFH4,Q8NFH5,Q8TD19,Q8TEM1,Q8WUM0,Q8WUX9,Q8WVM7,Q8WYP5,Q92530,Q92621,Q92674,Q92973,Q96CS2,Q96CW5,Q96DE5,Q96EA4,Q96EE3,Q96FJ2,Q99436,Q99460,Q99567,Q99661,Q99986,Q9BPX3,Q9BSJ2,Q9BTX1,Q9BUF5,Q9BVA1,Q9BVL2,Q9BW27,Q9BZD4,Q9H0U4,Q9H1A4,Q9H6D7,Q9H8Y8,Q9HBM1,Q9HC35,Q9NQS7,Q9NRG9,Q9NTI5,Q9NTJ3,Q9P258,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6,Q9UKX7,Q9UL46,Q9UN37,Q9UNM6,Q9UQE7,Q9UQN3,Q9Y266,Q9Y2U8,Q9Y6G9,Q9Y6X3 Synthesis of dna 86 117 6.847656683613436 4.2096411390125974e-23 2.869877089552936e-21 O00231,O00232,O00487,O14818,O43242,O43913,O75419,O75832,P09884,P12004,P15927,P17980,P18858,P20618,P24941,P25205,P25786,P25787,P25788,P25789,P27694,P28066,P28070,P28072,P28074,P28340,P30260,P33991,P33992,P33993,P35244,P35249,P35250,P35251,P35998,P39748,P40937,P40938,P41440,P43686,P48556,P49005,P49642,P49643,P49720,P49721,P49736,P51530,P51665,P55036,P60900,P61289,P62191,P62195,P62333,P63208,Q06323,Q07864,Q13200,Q13309,Q13616,Q14181,Q14566,Q14997,Q15008,Q16763,Q92530,Q96DE5,Q99436,Q99460,Q9BRT9,Q9BRX5,Q9H1A4,Q9NR33,Q9NRF9,Q9UBD5,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6,Q9UL46,Q9UNM6,Q9Y248,Q9Y2S7,Q9Y619 Mitotic metaphase and anaphase 136 225 3.806848582129481 1.2549823646827677e-22 8.199218115927415e-21 O00139,O00231,O00232,O00487,O14818,O14980,O43237,O43242,O43264,O43684,O60216,O60566,O75122,O75531,O75694,O75832,P02545,P04350,P06493,P14635,P17980,P18754,P20618,P20700,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P30153,P30154,P30260,P35998,P37198,P42166,P42167,P43034,P43686,P46060,P48556,P49720,P49721,P49792,P50402,P50748,P51665,P52948,P53350,P53990,P55036,P57740,P60900,P61289,P62191,P62195,P62333,P62826,P63151,P63167,P68371,Q06323,Q12769,Q13200,Q13257,Q13409,Q13885,Q14008,Q14204,Q14683,Q14738,Q14739,Q14974,Q14997,Q15005,Q15008,Q15691,Q16763,Q29RF7,Q2NKX8,Q53HL2,Q5SRE5,Q7Z3B4,Q7Z460,Q7Z5K2,Q86XL3,Q8IXJ6,Q8N1F7,Q8N3U4,Q8NBT2,Q8NC56,Q8NFH3,Q8NFH4,Q8NFH5,Q8WUM0,Q8WUX9,Q8WVM7,Q8WYP5,Q92530,Q92621,Q92674,Q92973,Q96DE5,Q96EA4,Q96EE3,Q96FJ2,Q99436,Q99460,Q99661,Q99986,Q9BTX1,Q9BUF5,Q9BVA1,Q9BVL2,Q9BW27,Q9BZD4,Q9H1A4,Q9HBM1,Q9NQS7,Q9NTI5,Q9P258,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6,Q9UL46,Q9UN37,Q9UNM6,Q9UQE7,Q9UQN3,Q9Y266,Q9Y2U8,Q9Y6G9 Transport of mature transcript to cytoplasm 65 81 9.976511786812436 2.365331219298456e-21 1.4835357407439916e-19 O00148,O15504,O60508,O75152,O75694,P06730,P12270,P26368,P35658,P37198,P38919,P49790,P49792,P52948,P57740,P78406,P82979,P84103,Q01081,Q05519,Q07955,Q08170,Q09161,Q10570,Q12769,Q13242,Q13243,Q13247,Q13769,Q13838,Q15287,Q16629,Q5SRE5,Q6UN15,Q7Z3B4,Q86V81,Q86W42,Q8IYB3,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8NI27,Q8TEM1,Q8WUM0,Q92620,Q92621,Q92797,Q96EE3,Q96FV9,Q96J01,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9BY77,Q9BZI7,Q9C0J8,Q9NRG9,Q9P2I0,Q9UBU9,Q9UKF6,Q9UKX7,Q9Y3Y2,Q9Y5S9 Neutrophil degranulation 172 319 2.9280744922082307 1.0650210790053376e-20 6.422896353386035e-19 O00161,O00231,O00232,O00264,O00487,O00560,O00571,O00584,O00754,O00764,O15126,O15260,O43242,O43681,O60610,O75131,O75165,O75874,O94973,P00387,P00491,P01889,P04066,P04075,P04080,P04439,P06280,P06737,P06744,P07355,P07384,P07437,P07602,P07686,P07741,P07900,P08236,P08238,P09110,P09429,P09960,P09972,P0DMV9,P10253,P10321,P10619,P11142,P11216,P11279,P11717,P12268,P12956,P13010,P13473,P13639,P13798,P14174,P14618,P14923,P15586,P15924,P16278,P17858,P17900,P17931,P17980,P18206,P18669,P20618,P20839,P22392,P25787,P27105,P28066,P28482,P30041,P30519,P31949,P35237,P35573,P35998,P36871,P37108,P39656,P42785,P46940,P46976,P50395,P50990,P51148,P51149,P51665,P53396,P53618,P53634,P53990,P55072,P61020,P61026,P61106,P61160,P61225,P61586,P61916,P63000,P63167,P67870,P68371,P68402,P78371,P84095,Q01518,Q07065,Q08722,Q12905,Q13162,Q13200,Q13217,Q13442,Q13464,Q13510,Q13576,Q13813,Q14019,Q14165,Q14204,Q14974,Q15008,Q16539,Q4KMQ2,Q5T4S7,Q5T9A4,Q6IAA8,Q7L576,Q7Z6Z7,Q86VP6,Q8N2G8,Q8NBS9,Q8NF37,Q8NHP6,Q92542,Q92820,Q93050,Q969Q5,Q96CS3,Q96G03,Q96JM3,Q99436,Q99439,Q99460,Q99536,Q99829,Q9BS26,Q9BTY2,Q9BU76,Q9BXS5,Q9H0U3,Q9H7Z7,Q9NP72,Q9NQR4,Q9NQX7,Q9NZ32,Q9NZJ7,Q9P0L0,Q9UJU6,Q9UNM6,Q9UNP9,Q9UQ80,Q9Y2Q5,Q9Y376,Q9Y5K8,Q9Y6G9 Rrna modification in the nucleus and cytosol 54 63 14.693669162695711 1.462659609888191e-20 8.494260252980311e-19 O00425,O00566,O00567,O15213,O43709,O43818,O60832,O75691,P15880,P22087,P46087,P46781,P55769,P62081,P62263,P62753,P78316,Q12788,Q13601,Q14690,Q14692,Q15061,Q15269,Q68CQ4,Q8IWA0,Q8IY37,Q8NI36,Q8TED0,Q92979,Q969X6,Q96G21,Q9BVI4,Q9BVJ6,Q9H0A0,Q9H0S4,Q9H583,Q9H6R4,Q9H8H0,Q9NQZ2,Q9NRX1,Q9NV06,Q9NV31,Q9NX24,Q9NXG2,Q9NY12,Q9NYH9,Q9UNQ2,Q9UNX4,Q9Y2P8,Q9Y2R4,Q9Y2X3,Q9Y3A2,Q9Y5J1,Q9Y6V7 Regulation of mrna stability by proteins that bind au rich elements 63 79 9.66293956981905 1.8183293177163342e-20 1.0182644179211471e-18 O00231,O00232,O00487,O14818,O14980,O43242,O75832,O95453,P04792,P11142,P11940,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P31946,P35658,P35998,P39687,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,P63104,Q01105,Q04637,Q06265,Q06323,Q13200,Q13868,Q14103,Q14997,Q15008,Q15024,Q15717,Q16539,Q5RKV6,Q92530,Q92945,Q92973,Q96B26,Q99436,Q99460,Q9NPD3,Q9NQT4,Q9NQT5,Q9UL46,Q9UNM6,Q9Y2L1,Q9Y3B2 Dna replication 92 137 5.046957854406131 3.721356616571508e-20 2.012099025787629e-18 O00231,O00232,O00487,O14818,O43242,O43913,O60684,O75419,O75832,P09884,P12004,P15927,P16104,P17980,P18858,P20618,P24941,P25205,P25786,P25787,P25788,P25789,P27694,P28066,P28070,P28072,P28074,P28340,P30260,P33991,P33992,P33993,P35244,P35249,P35250,P35251,P35998,P39748,P40937,P40938,P41440,P43686,P48556,P49005,P49642,P49643,P49720,P49721,P49736,P51530,P51665,P52294,P55036,P60900,P61289,P62191,P62195,P62333,P62805,P63208,Q06323,Q07864,Q13200,Q13309,Q13616,Q14181,Q14566,Q14974,Q14997,Q15008,Q16763,Q7L590,Q92530,Q96DE5,Q99436,Q99460,Q9BRT9,Q9BRX5,Q9H1A4,Q9NR33,Q9NRF9,Q9UBD5,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6,Q9UL46,Q9UNM6,Q9Y248,Q9Y2S7,Q9Y619 Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s 50 59 13.586751265201299 1.102321712994336e-18 5.761468153250397e-17 O00303,O15371,O15372,O75821,O75822,P05198,P06730,P08708,P08865,P11940,P15880,P20042,P23396,P23588,P25398,P39019,P46781,P46782,P46783,P55884,P56537,P60228,P60842,P60866,P61247,P62081,P62241,P62244,P62249,P62263,P62266,P62269,P62277,P62280,P62701,P62753,P62841,P62847,P62851,P62857,P62861,P63220,Q04637,Q13347,Q14152,Q14240,Q15056,Q7L2H7,Q9UBQ5,Q9Y262 S phase 97 158 3.923502930434044 3.888662141569188e-17 1.9669103993485442e-15 O00231,O00232,O00487,O14818,O43242,O43913,O60216,O75419,O75832,P09884,P11802,P12004,P15927,P17980,P18858,P20618,P24941,P25205,P25786,P25787,P25788,P25789,P27694,P28066,P28070,P28072,P28074,P28340,P30260,P31751,P33991,P33992,P33993,P35244,P35249,P35250,P35251,P35998,P39748,P40937,P40938,P41440,P43686,P48556,P49005,P49642,P49643,P49720,P49721,P49736,P49841,P51530,P51665,P55036,P60900,P61289,P62191,P62195,P62333,P63208,Q06323,Q07864,Q13200,Q13309,Q13616,Q14181,Q14566,Q14683,Q14997,Q15008,Q16763,Q29RF7,Q7Z5K2,Q8N3U4,Q8WVM7,Q92530,Q96DE5,Q99436,Q99460,Q9BRT9,Q9BRX5,Q9H1A4,Q9NR33,Q9NRF9,Q9NTI5,Q9UBD5,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6,Q9UL46,Q9UNM6,Q9UQE7,Q9Y248,Q9Y2S7,Q9Y619 Auf1 hnrnp d0 binds and destabilizes mrna 42 48 17.08 5.84838118932419e-17 2.8657067827688532e-15 O00231,O00232,O00487,O14818,O43242,O75832,P04792,P11142,P11940,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,Q04637,Q06323,Q13200,Q14103,Q14997,Q15008,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Innate immune system 277 624 2.016111792209998 1.3819251246343758e-16 6.566238167959701e-15 O00159,O00161,O00231,O00232,O00264,O00487,O00560,O00571,O00584,O00754,O00764,O14802,O14818,O15111,O15126,O15143,O15144,O15145,O15160,O15260,O43242,O43681,O43865,O60610,O75131,O75165,O75832,O75874,O94826,O94973,P00387,P00491,P01889,P04066,P04075,P04080,P04439,P05067,P06280,P06737,P06744,P07355,P07384,P07437,P07602,P07686,P07741,P07900,P08236,P08238,P09110,P09429,P09601,P09960,P09972,P0DMV9,P10253,P10321,P10619,P11142,P11216,P11279,P11717,P12268,P12956,P13010,P13473,P13639,P13798,P14174,P14314,P14618,P14625,P14923,P15586,P15924,P16278,P17612,P17858,P17900,P17931,P17980,P18206,P18669,P19174,P19388,P19474,P20618,P20839,P21281,P21283,P22392,P23528,P25786,P25787,P25788,P25789,P27105,P27361,P28066,P28070,P28072,P28074,P28482,P30041,P30153,P30154,P30519,P31949,P35222,P35237,P35573,P35579,P35998,P36543,P36871,P37108,P38606,P39656,P42785,P43686,P46108,P46940,P46976,P47755,P48556,P49720,P49721,P49959,P50395,P50570,P50990,P51148,P51149,P51452,P51665,P51812,P52907,P53396,P53618,P53634,P53990,P55036,P55072,P59998,P60900,P60953,P61020,P61026,P61081,P61086,P61088,P61106,P61158,P61160,P61225,P61289,P61421,P61586,P61916,P62191,P62195,P62333,P62875,P62993,P63000,P63167,P63208,P67870,P68371,P68402,P78371,P78527,P81605,P84095,Q01518,Q02750,Q06124,Q06323,Q07065,Q08209,Q08211,Q08722,Q12905,Q13162,Q13177,Q13200,Q13217,Q13442,Q13464,Q13510,Q13526,Q13546,Q13576,Q13616,Q13685,Q13813,Q14019,Q14165,Q14204,Q14258,Q14738,Q14974,Q14997,Q15008,Q15075,Q15366,Q15418,Q15750,Q16512,Q16539,Q4KMQ2,Q5T4S7,Q5T9A4,Q6IAA8,Q7L576,Q7Z434,Q7Z6Z7,Q86VP6,Q8IV08,Q8IV63,Q8N2G8,Q8NBS9,Q8NF37,Q8NHP6,Q8TBC4,Q92530,Q92542,Q92747,Q92820,Q93050,Q969Q5,Q96CS3,Q96F07,Q96G03,Q96J02,Q96JJ3,Q96JM3,Q99436,Q99439,Q99460,Q99536,Q99538,Q99570,Q99829,Q9BQ95,Q9BS26,Q9BTY2,Q9BU76,Q9BUI4,Q9BXS5,Q9H0U3,Q9H2U1,Q9H7Z7,Q9NP72,Q9NQR4,Q9NQX7,Q9NZ32,Q9NZI8,Q9NZJ7,Q9NZQ3,Q9P0L0,Q9UI12,Q9UJU6,Q9UJV9,Q9UL46,Q9UNM6,Q9UNP9,Q9UQ80,Q9UQB8,Q9Y2A7,Q9Y2Q5,Q9Y2Z0,Q9Y376,Q9Y487,Q9Y5K8,Q9Y6G9 Glucose metabolism 59 80 6.880603315311805 2.28698603388923e-16 1.0547041473936213e-14 A6NDG6,O15504,O75694,O75746,P00505,P00558,P04075,P04406,P06733,P06744,P08237,P09972,P11498,P12270,P14618,P17174,P17612,P17858,P18669,P19367,P30153,P30154,P35658,P37198,P40925,P40926,P46926,P49790,P49792,P52789,P52948,P53007,P57740,P60174,P78406,Q01813,Q02978,Q12769,Q14738,Q16822,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q99567,Q9BRR6,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UBX3,Q9UJS0,Q9UKX7 Cell cycle checkpoints 137 257 2.832772913018097 3.625328457611542e-16 1.624147149009971e-14 O00139,O00231,O00232,O00487,O14818,O14980,O43237,O43242,O43264,O43684,O43913,O60566,O60934,O75122,O75419,O75832,O96017,O96028,P04637,P06493,P14635,P15927,P16104,P17980,P20618,P24941,P25205,P25786,P25787,P25788,P25789,P27348,P27694,P28066,P28070,P28072,P28074,P30153,P30154,P30260,P31946,P33991,P33992,P33993,P35244,P35249,P35250,P35998,P38398,P40937,P40938,P43034,P43686,P46060,P48556,P49720,P49721,P49736,P49792,P49959,P50748,P51530,P51665,P52948,P53350,P54132,P55036,P57740,P60900,P61088,P61289,P61981,P62191,P62195,P62258,P62333,P62805,P63104,P63167,Q04917,Q06323,Q12769,Q12888,Q13200,Q13257,Q13409,Q14008,Q14204,Q14566,Q14676,Q14738,Q14997,Q15005,Q15008,Q15691,Q16763,Q2NKX8,Q53HL2,Q7L590,Q7Z460,Q8NBT2,Q8NFH3,Q8NFH4,Q8WUM0,Q8WYP5,Q92530,Q92674,Q92878,Q96DE5,Q96EA4,Q96EE3,Q96FJ2,Q99436,Q99460,Q99640,Q99661,Q9BW27,Q9BZD4,Q9H1A4,Q9HBM1,Q9NQS7,Q9NWV8,Q9NXR7,Q9P258,Q9UBD5,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6,Q9UL46,Q9UNM6,Q9UQ84,Q9Y266,Q9Y3B8,Q9Y619,Q9Y6G9 Cross presentation of soluble exogenous antigens endosomes 37 41 22.538071065989847 4.541732290256804e-16 1.978176730867408e-14 O00231,O00232,O00487,O14818,O43242,O75832,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,Q06323,Q13200,Q14997,Q15008,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Separation of sister chromatids 104 179 3.4229732225300094 6.671852756516317e-16 2.8274230060047528e-14 O00139,O00231,O00232,O00487,O14818,O14980,O43237,O43242,O43264,O43684,O60216,O60566,O75122,O75832,P04350,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P30153,P30154,P30260,P35998,P43034,P43686,P46060,P48556,P49720,P49721,P49792,P50748,P51665,P52948,P53350,P55036,P57740,P60900,P61289,P62191,P62195,P62333,P63167,P68371,Q06323,Q12769,Q13200,Q13257,Q13409,Q13885,Q14008,Q14204,Q14683,Q14738,Q14997,Q15005,Q15008,Q15691,Q16763,Q29RF7,Q2NKX8,Q53HL2,Q7Z460,Q7Z5K2,Q8N3U4,Q8NBT2,Q8NFH3,Q8NFH4,Q8WUM0,Q8WVM7,Q8WYP5,Q92530,Q92674,Q96DE5,Q96EA4,Q96EE3,Q96FJ2,Q99436,Q99460,Q99661,Q9BUF5,Q9BVA1,Q9BW27,Q9BZD4,Q9H1A4,Q9HBM1,Q9NQS7,Q9NTI5,Q9P258,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6,Q9UL46,Q9UNM6,Q9UQE7,Q9Y266,Q9Y6G9 Cellular response to starvation 86 139 3.99294887610539 1.2407750460577525e-15 5.119829663733042e-14 P05198,P05387,P05388,P08243,P08708,P08865,P15880,P18077,P18124,P18621,P20042,P21281,P21283,P23396,P25398,P26373,P27635,P30050,P32969,P35268,P36543,P36578,P38606,P39019,P39023,P40429,P42345,P42766,P46776,P46777,P46778,P46779,P46781,P46782,P46783,P47914,P49207,P50914,P60866,P61247,P61254,P61313,P61353,P61421,P61513,P61927,P62081,P62241,P62244,P62249,P62263,P62266,P62269,P62277,P62280,P62424,P62701,P62750,P62753,P62829,P62841,P62847,P62851,P62857,P62861,P62888,P62899,P62906,P62910,P62913,P62917,P63173,P63220,P83731,P83881,P84098,Q02543,Q02878,Q07020,Q6IAA8,Q92616,Q96EE3,Q9UI12,Q9Y2Q5,Q9Y3U8,Q9Y5K8 Disorders of transmembrane transporters 75 115 4.604902296880357 1.3213728853472817e-15 5.312596626216763e-14 O00231,O00232,O00487,O14818,O15504,O43242,O75477,O75694,O75832,O94905,P08195,P11166,P12270,P17980,P19367,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35613,P35658,P35998,P37198,P43686,P48556,P49720,P49721,P49790,P49792,P51665,P52948,P53985,P55036,P55072,P57740,P60900,P61289,P62191,P62195,P62333,P78406,Q06323,Q12769,Q13200,Q14997,Q15008,Q5SRE5,Q6P1M0,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92530,Q92621,Q96EE3,Q99436,Q99460,Q99567,Q9BTX1,Q9BUN8,Q9BVL2,Q9BW27,Q9NRG9,Q9UBV2,Q9UKX7,Q9UL46,Q9UNM6 Dna replication pre initiation 64 92 5.601873536299766 1.4110273400372871e-15 5.5312271729461656e-14 O00231,O00232,O00487,O14818,O43242,O43913,O60684,O75419,O75832,P09884,P15927,P16104,P17980,P20618,P24941,P25205,P25786,P25787,P25788,P25789,P27694,P28066,P28070,P28072,P28074,P33991,P33992,P33993,P35244,P35998,P43686,P48556,P49642,P49643,P49720,P49721,P49736,P51665,P52294,P55036,P60900,P61289,P62191,P62195,P62333,P62805,Q06323,Q07864,Q13200,Q14181,Q14566,Q14974,Q14997,Q15008,Q7L590,Q92530,Q99436,Q99460,Q9NR33,Q9NRF9,Q9UBD5,Q9UL46,Q9UNM6,Q9Y619 The citric acid tca cycle and respiratory electron transport 95 160 3.601630333767027 1.797512181906185e-15 6.8743880517778e-14 O00217,O00330,O00483,O14949,O43674,O43676,O43678,O43708,O43819,O43837,O75251,O75306,O75380,O75390,O75489,O75880,O75947,O75964,O95168,O95182,O95299,O95563,O96000,P00338,P00403,P03886,P06576,P07195,P07954,P08559,P08574,P09622,P09669,P10515,P10606,P11177,P13073,P13804,P14927,P15954,P19404,P20674,P21796,P21912,P22695,P23368,P24539,P25705,P28331,P31040,P31930,P35613,P36542,P36957,P38117,P40926,P42704,P48047,P48163,P48735,P49821,P50213,P51970,P53597,P53985,P56134,P56385,Q02218,Q04760,Q12931,Q13423,Q15118,Q15120,Q16134,Q16718,Q16795,Q6P587,Q7L592,Q86Y39,Q8N183,Q8NCN5,Q8TB37,Q96I99,Q99798,Q9BQ95,Q9BU61,Q9H845,Q9H9P8,Q9NPL8,Q9NX14,Q9P032,Q9P0J0,Q9P2R7,Q9UDW1,Q9Y6M9 Interactions of vpr with host cellular proteins 34 37 27.590038314176244 1.9759882696548863e-15 7.20546420190433e-14 O15504,O75475,O75531,O75694,P05141,P12235,P12236,P12270,P17096,P35658,P37198,P49790,P49792,P52294,P52948,P57740,P78406,Q12769,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7 Interactions of rev with host cellular proteins 34 37 27.590038314176244 1.9759882696548863e-15 7.20546420190433e-14 O14980,O15504,O75694,P06748,P12270,P18754,P35658,P37198,P43487,P46060,P49790,P49792,P52948,P57740,P62826,P78406,Q12769,Q14974,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7 Orc1 removal from chromatin 50 65 8.145252662587808 2.450024215665487e-15 8.73099538673519e-14 O00231,O00232,O00487,O14818,O43242,O43913,O75832,P17980,P20618,P24941,P25205,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P33991,P33992,P33993,P35998,P43686,P48556,P49720,P49721,P49736,P51665,P55036,P60900,P61289,P62191,P62195,P62333,P63208,Q06323,Q13200,Q13309,Q13616,Q14566,Q14997,Q15008,Q92530,Q99436,Q99460,Q9UBD5,Q9UL46,Q9UNM6,Q9Y619 G2 m checkpoints 83 134 4.001772726966345 3.560894875755398e-15 1.2407740367076588e-13 O00231,O00232,O00487,O14818,O43242,O43913,O60934,O75419,O75832,O96017,O96028,P04637,P06493,P14635,P15927,P16104,P17980,P20618,P24941,P25205,P25786,P25787,P25788,P25789,P27348,P27694,P28066,P28070,P28072,P28074,P31946,P33991,P33992,P33993,P35244,P35249,P35250,P35998,P38398,P40937,P40938,P43686,P48556,P49720,P49721,P49736,P49959,P51530,P51665,P54132,P55036,P60900,P61088,P61289,P61981,P62191,P62195,P62258,P62333,P62805,P63104,Q04917,Q06323,Q12888,Q13200,Q14566,Q14676,Q14997,Q15008,Q7L590,Q92530,Q92878,Q99436,Q99460,Q99640,Q9NWV8,Q9NXR7,Q9UBD5,Q9UL46,Q9UNM6,Q9UQ84,Q9Y3B8,Q9Y619 Nervous system development 206 443 2.1736197564071107 4.737912354942341e-15 1.615010124467302e-13 A0MZ66,O00231,O00232,O00487,O00560,O14818,O15020,O15143,O15144,O15145,O43242,O75116,O75122,O75832,O94813,O94973,O95239,O95782,P04350,P05387,P05388,P05556,P07737,P07900,P08238,P08708,P08865,P09496,P09497,P11142,P11940,P13861,P15170,P15311,P15880,P17612,P17980,P18077,P18124,P18621,P19174,P19784,P20618,P23396,P23528,P25398,P25786,P25787,P25788,P25789,P26038,P26373,P27361,P27635,P28066,P28070,P28072,P28074,P28482,P30050,P32969,P35080,P35241,P35268,P35579,P35580,P35998,P36578,P38919,P39019,P39023,P40429,P42766,P43686,P46776,P46777,P46778,P46779,P46781,P46782,P46783,P46939,P47914,P48556,P49207,P49720,P49721,P49841,P50570,P50914,P51532,P51665,P51812,P53680,P55036,P59998,P60660,P60866,P60900,P60953,P61158,P61160,P61247,P61254,P61289,P61313,P61353,P61513,P61586,P61927,P62081,P62191,P62195,P62241,P62244,P62249,P62263,P62266,P62269,P62277,P62280,P62333,P62424,P62495,P62701,P62750,P62753,P62829,P62841,P62847,P62851,P62857,P62861,P62888,P62899,P62906,P62910,P62913,P62917,P62993,P63000,P63010,P63173,P63220,P67870,P68371,P83731,P83881,P84098,Q00535,Q00610,Q01082,Q01518,Q02543,Q02750,Q02878,Q04637,Q06124,Q06323,Q07020,Q09161,Q12955,Q13177,Q13200,Q13464,Q13617,Q13813,Q13885,Q14195,Q14997,Q15008,Q15287,Q15334,Q15369,Q15370,Q15375,Q15418,Q16512,Q16539,Q16555,Q16850,Q7Z406,Q7Z460,Q8N8S7,Q92530,Q92542,Q92747,Q92769,Q96CW1,Q96P70,Q96S59,Q99436,Q99460,Q9BPU6,Q9BUF5,Q9BVA1,Q9BZI7,Q9HAU5,Q9NR12,Q9NR77,Q9NWH9,Q9UL46,Q9UNM6,Q9Y3U8,Q9Y490,Q9Y5S9 Regulation of hsf1 mediated heat shock response 55 76 6.405386124487248 9.40165407795167e-15 3.136551828559196e-13 O15504,O75694,O95429,O95757,O95816,O95817,P04792,P0DMV9,P11142,P12270,P15927,P25685,P27361,P27694,P28482,P34932,P35244,P35658,P37198,P38646,P48723,P49790,P49792,P49841,P50454,P52948,P54652,P57740,P62258,P78406,Q02790,Q0VDF9,Q12769,Q5SRE5,Q7Z3B4,Q8N163,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92598,Q92621,Q96EB6,Q96EE3,Q99543,Q99567,Q99615,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7,Q9UL15 Transport of mature mrnas derived from intronless transcripts 37 43 15.021206993795825 1.4056610720782863e-14 4.591826168789068e-13 O15504,O75694,P06730,P12270,P35658,P37198,P49790,P49792,P52948,P57740,P78406,Q09161,Q10570,Q12769,Q5SRE5,Q6UN15,Q7Z3B4,Q86V81,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92621,Q92797,Q96EE3,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9C0J8,Q9NRG9,Q9P2I0,Q9UBU9,Q9UKF6,Q9UKX7 Vesicle mediated transport 242 546 1.9973684210526317 1.7019663252395545e-14 5.446292240766574e-13 A2RRP1,O00139,O00159,O00161,O00186,O00203,O00443,O00461,O00471,O00743,O14579,O14964,O14976,O15020,O15027,O15144,O15145,O15260,O15498,O43237,O43264,O43747,O60343,O60645,O60664,O60749,O60763,O75351,O75396,O75935,O75976,O94973,O94979,O95235,O95239,O95249,O95486,O95487,O95782,P02786,P04350,P05067,P07900,P09496,P09497,P11142,P11233,P11717,P14625,P15586,P18085,P20338,P20339,P20645,P22681,P24390,P27348,P27797,P31150,P31751,P31946,P33176,P35579,P35606,P40616,P42566,P43034,P46459,P47755,P47756,P48444,P49257,P49755,P50395,P50570,P51148,P51149,P51151,P51153,P51809,P52732,P52907,P53618,P53621,P53634,P53680,P53992,P54619,P54920,P55327,P59998,P60520,P61006,P61020,P61026,P61106,P61158,P61160,P61163,P61201,P61923,P61981,P62258,P62330,P62820,P62993,P63000,P63010,P63104,P63167,P68371,P68402,P83436,P84085,Q00610,Q01082,Q01968,Q02241,Q04917,Q07157,Q07866,Q08379,Q10471,Q10472,Q10567,Q12756,Q12846,Q12907,Q12955,Q12981,Q13098,Q13190,Q13409,Q13492,Q13561,Q13813,Q13885,Q14108,Q14203,Q14204,Q14247,Q14671,Q14677,Q14789,Q14807,Q14C86,Q15042,Q15102,Q15286,Q15363,Q15436,Q16706,Q4KMP7,Q5H9R7,Q5JRA6,Q5KU26,Q5VIR6,Q5VZE5,Q6NUQ1,Q7L5N1,Q7Z392,Q86YS7,Q8IUR0,Q8IWJ2,Q8IYI6,Q8N6T3,Q8NBS9,Q8TAG9,Q8TBA6,Q8TC07,Q8TD16,Q8WTV0,Q8WUX9,Q8WVM8,Q92538,Q92572,Q92598,Q92734,Q92747,Q92783,Q92905,Q96A65,Q96CW1,Q96D71,Q96FJ2,Q96KP1,Q96PC5,Q99523,Q99627,Q99661,Q99747,Q99816,Q99961,Q9BRG1,Q9BT78,Q9BUF5,Q9BVA1,Q9BVK6,Q9BW19,Q9BXS5,Q9BZE9,Q9H0B6,Q9H0H5,Q9H0U4,Q9H2M9,Q9H3P7,Q9H9H4,Q9HCU5,Q9NP72,Q9NP79,Q9NVG8,Q9NVZ3,Q9NZ32,Q9NZZ3,Q9P2W9,Q9UBC2,Q9UBF2,Q9UBW8,Q9UID3,Q9UIQ6,Q9UJW0,Q9UJY4,Q9UKS6,Q9UL25,Q9UM54,Q9UN37,Q9UNF0,Q9UNS2,Q9UPT5,Q9UQN3,Q9Y296,Q9Y3B3,Q9Y3B8,Q9Y3P9,Q9Y496,Q9Y4L1,Q9Y5X1,Q9Y5X3,Q9Y678,Q9Y6B6,Q9Y6G9,Q9Y6Y8 Switching of origins to a post replicative state 59 85 5.553541923470324 2.1414801346296366e-14 6.71568170219854e-13 O00231,O00232,O00487,O14818,O43242,O43913,O75832,P17980,P20618,P24941,P25205,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P30260,P33991,P33992,P33993,P35998,P43686,P48556,P49720,P49721,P49736,P51665,P55036,P60900,P61289,P62191,P62195,P62333,P63208,Q06323,Q13200,Q13309,Q13616,Q14566,Q14997,Q15008,Q16763,Q92530,Q96DE5,Q99436,Q99460,Q9H1A4,Q9UBD5,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6,Q9UL46,Q9UNM6,Q9Y619 Apc c mediated degradation of cell cycle proteins 57 81 5.810051107325383 2.2885293511558342e-14 7.036105926690878e-13 O00231,O00232,O00487,O14818,O14965,O43242,O43684,O60566,O75832,P06493,P14635,P17980,P20618,P24941,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P30260,P35998,P43686,P48556,P49720,P49721,P51665,P53350,P55036,P60900,P61289,P62191,P62195,P62333,P63208,Q06323,Q13200,Q13257,Q13309,Q13616,Q14997,Q15008,Q16763,Q92530,Q96DE5,Q99436,Q99460,Q9H1A4,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6,Q9UL46,Q9UNM6 Regulation of hmox1 expression and activity 45 58 8.446529717313565 3.556715559681307e-14 1.0724865379962094e-12 O00231,O00232,O00487,O14818,O43242,O75832,P09601,P17980,P19784,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,P63208,P67870,Q06323,Q13200,Q13309,Q13616,Q13618,Q14997,Q15008,Q8TCT9,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Negative regulation of notch4 signaling 40 49 10.832580548027703 4.275411722228427e-14 1.264876524613995e-12 O00231,O00232,O00487,O14818,O43242,O75832,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,P63104,P63208,Q06323,Q13200,Q13616,Q15008,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6,Q9Y6A5 Nuclear import of rev protein 31 34 25.130136215242597 6.176658394136101e-14 1.793518585556557e-12 O15504,O75694,P06748,P12270,P18754,P35658,P37198,P49790,P49792,P52948,P57740,P62826,P78406,Q12769,Q14974,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7 Membrane trafficking 235 532 1.9822759086451505 6.59996437286874e-14 1.8815898430287607e-12 A2RRP1,O00139,O00159,O00161,O00186,O00203,O00443,O00461,O00471,O00743,O14579,O14964,O14976,O15020,O15027,O15144,O15145,O15260,O15498,O43237,O43264,O43747,O60343,O60645,O60664,O60749,O60763,O75351,O75396,O75935,O75976,O94973,O94979,O95235,O95239,O95249,O95486,O95487,O95782,P02786,P04350,P05067,P09496,P09497,P11142,P11233,P11717,P15586,P18085,P20338,P20339,P20645,P22681,P24390,P27348,P31150,P31751,P31946,P33176,P35579,P35606,P40616,P42566,P43034,P46459,P47755,P47756,P48444,P49257,P49755,P50395,P50570,P51148,P51149,P51151,P51153,P51809,P52732,P52907,P53618,P53621,P53634,P53680,P53992,P54619,P54920,P55327,P59998,P60520,P61006,P61020,P61026,P61106,P61158,P61160,P61163,P61201,P61923,P61981,P62258,P62330,P62820,P62993,P63000,P63010,P63104,P63167,P68371,P68402,P83436,P84085,Q00610,Q01082,Q01968,Q02241,Q04917,Q07157,Q07866,Q08379,Q10471,Q10472,Q10567,Q12756,Q12846,Q12907,Q12955,Q12981,Q13098,Q13190,Q13409,Q13492,Q13561,Q13813,Q13885,Q14108,Q14203,Q14204,Q14247,Q14671,Q14677,Q14789,Q14807,Q14C86,Q15042,Q15102,Q15286,Q15363,Q15436,Q16706,Q4KMP7,Q5H9R7,Q5JRA6,Q5VIR6,Q5VZE5,Q6NUQ1,Q7L5N1,Q7Z392,Q86YS7,Q8IUR0,Q8IWJ2,Q8IYI6,Q8N6T3,Q8NBS9,Q8TAG9,Q8TBA6,Q8TC07,Q8TD16,Q8WUX9,Q8WVM8,Q92538,Q92572,Q92734,Q92747,Q92783,Q92905,Q96A65,Q96CW1,Q96D71,Q96FJ2,Q96KP1,Q96PC5,Q99523,Q99627,Q99661,Q99747,Q99816,Q99961,Q9BRG1,Q9BT78,Q9BUF5,Q9BVA1,Q9BVK6,Q9BW19,Q9BXS5,Q9BZE9,Q9H0B6,Q9H0H5,Q9H0U4,Q9H2M9,Q9H3P7,Q9H9H4,Q9HCU5,Q9NP72,Q9NP79,Q9NVG8,Q9NVZ3,Q9NZ32,Q9NZZ3,Q9P2W9,Q9UBC2,Q9UBF2,Q9UBW8,Q9UID3,Q9UIQ6,Q9UJW0,Q9UJY4,Q9UKS6,Q9UL25,Q9UM54,Q9UN37,Q9UNF0,Q9UNS2,Q9UPT5,Q9UQN3,Q9Y296,Q9Y3B3,Q9Y3B8,Q9Y3P9,Q9Y496,Q9Y5X1,Q9Y5X3,Q9Y678,Q9Y6B6,Q9Y6G9,Q9Y6Y8 Dectin 1 mediated noncanonical nf kb signaling 42 53 9.30989214175655 6.861370046788045e-14 1.9211836131006524e-12 O00231,O00232,O00487,O14818,O15111,O43242,O75832,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61081,P61289,P62191,P62195,P62333,P63208,Q06323,Q13200,Q13616,Q14997,Q15008,Q8TBC4,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Cellular response to heat stress 62 93 4.896245733788396 8.614849640150835e-14 2.3698393396064053e-12 O15504,O75694,O95429,O95757,O95816,O95817,P04792,P07900,P08238,P0DMV9,P11142,P12270,P15927,P25685,P27361,P27694,P28482,P34932,P35244,P35658,P37198,P38646,P42345,P48723,P49790,P49792,P49841,P50454,P52948,P54652,P55072,P57740,P62258,P78406,Q02790,Q0VDF9,Q12769,Q13555,Q15185,Q5SRE5,Q7Z3B4,Q8N163,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92598,Q92621,Q96B36,Q96EB6,Q96EE3,Q99543,Q99567,Q99615,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7,Q9UL15 Golgi to er retrograde transport 72 115 4.10633959859828 1.1038761414720464e-13 2.984272051427877e-12 A2RRP1,O00139,O14579,O15260,O43237,O43264,O75396,O75935,O95235,O95239,P04350,P18085,P24390,P33176,P35606,P43034,P46459,P47755,P47756,P48444,P49755,P52732,P52907,P53618,P53621,P54920,P61163,P61923,P62820,P63167,P68371,P68402,P84085,Q02241,Q07866,Q10471,Q10472,Q12756,Q12981,Q13409,Q13561,Q13885,Q14203,Q14204,Q14807,Q15042,Q15102,Q15363,Q6NUQ1,Q8N6T3,Q8TD16,Q92538,Q96FJ2,Q99661,Q99747,Q9BUF5,Q9BVA1,Q9BVK6,Q9BW19,Q9H0B6,Q9H0H5,Q9H0U4,Q9H2M9,Q9NP72,Q9NZ32,Q9P2W9,Q9UBF2,Q9UJW0,Q9Y3B3,Q9Y496,Q9Y678,Q9Y6G9 Metabolism of polyamines 39 48 10.558189411897505 1.2023117670759e-13 3.1952963572457817e-12 O00231,O00232,O00487,O14818,O43242,O75832,P17980,P19623,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P52788,P55036,P60900,P61289,P62191,P62195,P62333,Q06323,Q13200,Q14997,Q15008,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 The role of gtse1 in g2 m progression after g2 checkpoint 49 67 6.646921131120927 1.402817819089563e-13 3.666030567220724e-12 O00231,O00232,O00487,O14818,O43242,O75832,P04350,P04637,P06493,P07900,P08238,P14635,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P53350,P55036,P60900,P61289,P62191,P62195,P62333,P68371,Q06323,Q13200,Q13885,Q14997,Q15008,Q15691,Q92530,Q99436,Q99460,Q9BUF5,Q9BVA1,Q9UL46,Q9UNM6 Rhobtb gtpase cycle 30 33 24.311276164753544 1.93474880642678e-13 4.9732559483232635e-12 O43396,O75116,P07900,P07910,P08238,P08670,P12814,P38159,P40227,P61201,P62995,P78371,Q12792,Q13098,Q13464,Q13618,Q13838,Q16543,Q16643,Q5VTR2,Q7Z6E9,Q8IYB3,Q8N684,Q8WWQ0,Q96DH6,Q96T58,Q99832,Q9BT78,Q9NYL9,Q9UM54 Defective cftr causes cystic fibrosis 42 54 8.532881355932203 2.2127891471086467e-13 5.5962151333328355e-12 O00231,O00232,O00487,O14818,O43242,O75477,O75832,O94905,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P55072,P60900,P61289,P62191,P62195,P62333,Q06323,Q13200,Q14997,Q15008,Q92530,Q99436,Q99460,Q9BUN8,Q9UBV2,Q9UL46,Q9UNM6 Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 49 68 6.296206878051398 3.595798517442412e-13 8.80970636773391e-12 O00231,O00232,O00487,O14818,O14965,O43242,O75832,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P30260,P35998,P43686,P48556,P49720,P49721,P51665,P53350,P55036,P60900,P61289,P62191,P62195,P62333,Q06323,Q13200,Q13309,Q14997,Q15008,Q16763,Q92530,Q96DE5,Q99436,Q99460,Q9H1A4,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6,Q9UL46,Q9UNM6 Glycolysis 48 66 6.509057971014493 3.5424660201725515e-13 8.80970636773391e-12 A6NDG6,O15504,O75694,P00558,P04075,P04406,P06733,P06744,P08237,P09972,P12270,P14618,P17612,P17858,P18669,P19367,P30153,P30154,P35658,P37198,P46926,P49790,P49792,P52789,P52948,P57740,P60174,P78406,Q01813,Q12769,Q14738,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q99567,Q9BRR6,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7 Degradation of gli1 by the proteasome 41 53 8.326894837908053 5.933454076952214e-13 1.4313316911786264e-11 O00231,O00232,O00487,O14818,O43242,O75832,P17612,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,P63208,Q06323,Q13200,Q13616,Q14997,Q15008,Q92530,Q96J02,Q99436,Q99460,Q9UL46,Q9UNM6 Export of viral ribonucleoproteins from nucleus 29 32 23.492968837889528 6.041616598235664e-13 1.4353416403081095e-11 O14980,O15504,O75694,P12270,P35658,P37198,P49790,P49792,P52948,P57740,P62826,P78406,Q12769,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7 Antiviral mechanism by ifn stimulated genes 51 73 5.66106148187073 8.467968913470063e-13 1.9817575009434417e-11 O00505,O15504,O43432,O60573,O75369,O75694,P06730,P12270,P19174,P19525,P21333,P27361,P35658,P37198,P38919,P42224,P49790,P49792,P52292,P52294,P52948,P57740,P60842,P61088,P61221,P78344,P78406,Q04637,Q12769,Q13526,Q14240,Q14258,Q14974,Q5SRE5,Q6L8Q7,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7,Q9Y4X5 Scf skp2 mediated degradation of p27 p21 41 54 7.685295727654251 1.7667858856167327e-12 4.074000395069172e-11 O00231,O00232,O00487,O14818,O43242,O75832,P11802,P17980,P20618,P24941,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,P63208,Q06323,Q13200,Q13309,Q13616,Q15008,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Transport of the slbp dependant mature mrna 31 36 15.073893954745019 2.00665419128122e-12 4.56004894482457e-11 O15504,O75694,P06730,P12270,P35658,P37198,P49790,P49792,P52948,P57740,P78406,Q09161,Q12769,Q5SRE5,Q7Z3B4,Q86V81,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UBU9,Q9UKX7 Trna aminoacylation 35 43 10.646770375380454 2.0381492300034824e-12 4.5654542752078006e-11 O43324,O43776,P07814,P14868,P23381,P26639,P26640,P41250,P41252,P47897,P49588,P49589,P49591,P54136,P54577,P56192,Q12904,Q13155,Q15031,Q15046,Q15181,Q5JPH6,Q5JTZ9,Q5ST30,Q5T160,Q6PI48,Q96GW9,Q9BW92,Q9H2U2,Q9NP81,Q9NSD9,Q9NSE4,Q9P2J5,Q9Y285,Q9Y2Z4 Stabilization of p53 39 51 7.915340331865899 4.195555782300247e-12 9.265678122037728e-11 O00231,O00232,O00487,O14818,O43242,O75832,O96017,P04637,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,Q06323,Q13200,Q14997,Q15008,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Ns1 mediated effects on host pathways 33 40 11.466277217206585 4.324851868958675e-12 9.418566292398891e-11 O00505,O15504,O75694,P12270,P19525,P35658,P37198,P49790,P49792,P52292,P52294,P52948,P57740,P78406,Q12769,Q14974,Q5SRE5,Q7Z3B4,Q86U42,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7 Hedgehog ligand biogenesis 40 53 7.4953095684803 4.6252582692433196e-12 9.800547251585845e-11 O00231,O00232,O00487,O14818,O43242,O75832,P07237,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P55072,P60900,P61289,P62191,P62195,P62333,Q06323,Q13200,Q14997,Q15008,Q92530,Q99436,Q99460,Q9UBV2,Q9UL46,Q9UNM6 Snrnp assembly 40 53 7.4953095684803 4.6252582692433196e-12 9.800547251585845e-11 O14744,O15504,O75694,P12270,P35658,P37198,P49790,P49792,P52948,P54105,P57678,P57740,P62304,P62314,P62316,P62318,P78406,Q09161,Q12769,Q16637,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8TEQ6,Q8WUM0,Q92621,Q96EE3,Q99567,Q9BQA1,Q9BTX1,Q9BVL2,Q9BW27,Q9H814,Q9NRG9,Q9UHI6,Q9UKX7 Dna strand elongation 30 35 14.582714382174206 5.940516248724489e-12 1.2419639304e-10 O75419,P09884,P12004,P15927,P18858,P25205,P27694,P28340,P33991,P33992,P33993,P35244,P35249,P35250,P35251,P39748,P40937,P40938,P41440,P49005,P49642,P49643,P49736,P51530,Q14181,Q14566,Q9BRT9,Q9BRX5,Q9Y248,Q9Y2S7 Programmed cell death 96 179 2.8440391399853557 6.424567053790581e-12 1.3254896237294253e-10 O00231,O00232,O00273,O00429,O00487,O00560,O14818,O15294,O43242,O60313,O75832,O75955,P02545,P04637,P07305,P07900,P08670,P09429,P10412,P15924,P16402,P16403,P17980,P20618,P20700,P25786,P25787,P25788,P25789,P26583,P27348,P27361,P28066,P28070,P28072,P28074,P28482,P30419,P31751,P31946,P35222,P35611,P35998,P40763,P41440,P43686,P48556,P49327,P49720,P49721,P51572,P51665,P52294,P55036,P60900,P61289,P61981,P62191,P62195,P62258,P62333,P63104,P63167,Q04917,Q06323,Q07021,Q07157,Q13177,Q13200,Q13464,Q13546,Q13813,Q14126,Q14254,Q14974,Q14997,Q15008,Q15149,Q16543,Q16625,Q8WUM4,Q8WUX9,Q92530,Q96FJ2,Q99436,Q99460,Q9NR28,Q9P289,Q9UDY2,Q9UJU6,Q9UKV3,Q9UL46,Q9UNE7,Q9UNM6,Q9UQN3,Q9Y3B8 Viral messenger rna synthesis 35 44 9.46248074249427 7.150341113275715e-12 1.4560694630670547e-10 O15504,O15514,O75694,P12270,P19387,P19388,P24928,P30876,P35269,P35658,P37198,P49790,P49792,P52948,P57740,P62487,P62875,P78406,Q12769,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7 Cytosolic trna aminoacylation 23 24 55.7995958235096 9.224215550900995e-12 1.8543038440785592e-10 O43324,O43776,P07814,P14868,P23381,P26639,P26640,P41250,P41252,P47897,P49588,P49589,P49591,P54136,P54577,P56192,Q12904,Q13155,Q15046,Q15181,Q9NSD9,Q9P2J5,Q9Y285 Degradation of axin 37 48 8.187694200892171 9.888202044346659e-12 1.9626203551310835e-10 O00231,O00232,O00487,O14818,O43242,O75832,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,Q06323,Q13200,Q14997,Q15008,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Degradation of dvl 38 50 7.709772060482961 1.1058604042025506e-11 2.167486392236999e-10 O00231,O00232,O00487,O14818,O43242,O75832,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,Q06323,Q13200,Q13618,Q14997,Q15008,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Rna polymerase ii transcription termination 46 66 5.6086897488119485 1.2870102454487538e-11 2.431363933570658e-10 O00148,O43809,O60508,O75152,P26368,P33240,P38919,P51003,P62304,P62318,P82979,P84103,Q01081,Q05048,Q05519,Q07955,Q08170,Q09161,Q10570,Q12996,Q13242,Q13243,Q13247,Q13769,Q13838,Q15287,Q16629,Q5KU26,Q6UN15,Q86U42,Q86V81,Q86W42,Q8IYB3,Q8N684,Q8NI27,Q92620,Q92797,Q96FV9,Q96J01,Q9BY77,Q9BZI7,Q9C0J8,Q9P2I0,Q9UKF6,Q9Y3Y2,Q9Y5S9 Nuclear envelope breakdown 40 54 6.958962446767325 1.2792322222572415e-11 2.431363933570658e-10 O15504,O75531,O75694,P02545,P06493,P12270,P14635,P20700,P35658,P37198,P42166,P42167,P49790,P49792,P50402,P52948,P53350,P57740,P78406,Q12769,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NC56,Q8NFH3,Q8NFH4,Q8NFH5,Q8TD19,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q99567,Q99986,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7,Q9Y2U8 Cdt1 association with the cdc6 orc origin complex 40 54 6.958962446767325 1.2792322222572415e-11 2.431363933570658e-10 O00231,O00232,O00487,O14818,O43242,O43913,O75832,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,Q06323,Q13200,Q14997,Q15008,Q92530,Q99436,Q99460,Q9UBD5,Q9UL46,Q9UNM6,Q9Y619 Tnfr2 non canonical nf kb pathway 42 58 6.396101694915254 1.3616712384670835e-11 2.541786311805223e-10 O00231,O00232,O00487,O14818,O15111,O43242,O75832,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61081,P61289,P62191,P62195,P62333,P63208,Q06323,Q13200,Q13616,Q14997,Q15008,Q8TBC4,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Signaling by rho gtpases miro gtpases and rhobtb3 248 593 1.7968394811340684 1.7217561276847135e-11 3.1761336567172127e-10 A4D1P6,O00139,O00161,O14964,O14974,O14980,O15143,O15144,O15145,O15173,O15498,O43237,O43264,O43396,O43663,O43684,O60341,O60566,O60610,O60664,O75116,O75122,O75323,O75489,O75955,O75976,O95140,O95202,O95292,P02786,P04350,P05556,P06753,P07737,P07900,P07910,P08238,P08670,P11182,P12277,P12814,P14923,P15924,P16104,P20700,P21333,P23528,P27105,P27348,P27361,P28288,P28482,P30153,P30154,P30519,P31946,P31948,P33176,P34897,P35080,P35221,P35222,P35579,P35580,P38159,P40227,P41240,P41440,P42166,P42167,P43034,P46060,P46940,P47756,P49257,P49792,P50402,P50748,P51149,P51151,P51572,P51648,P52306,P52565,P52948,P53350,P55072,P57740,P59998,P60660,P60953,P61158,P61160,P61201,P61586,P61604,P61981,P62140,P62258,P62805,P62993,P62995,P63000,P63104,P63167,P67936,P68371,P78371,P80723,P84095,Q00610,Q01082,Q01968,Q02952,Q03001,Q04917,Q07021,Q07065,Q07866,Q07960,Q08378,Q12769,Q12792,Q13098,Q13112,Q13177,Q13190,Q13257,Q13409,Q13464,Q13492,Q13505,Q13526,Q13576,Q13618,Q13813,Q13838,Q13885,Q14008,Q14126,Q14160,Q14204,Q14247,Q14254,Q14344,Q14738,Q14739,Q15005,Q15058,Q15334,Q15691,Q15758,Q15904,Q16512,Q16513,Q16539,Q16543,Q16643,Q16718,Q2NKX8,Q53HL2,Q5JTV8,Q5T2T1,Q5T8D3,Q5VTR2,Q68EM7,Q6IAA8,Q7L576,Q7Z406,Q7Z460,Q7Z6E9,Q86UP2,Q86XL3,Q8IWA4,Q8IXI1,Q8IXI2,Q8IYB3,Q8N684,Q8NBN3,Q8NBT2,Q8NFH3,Q8NFH4,Q8NHP6,Q8TAA9,Q8WUM0,Q8WVM8,Q8WWQ0,Q8WYP5,Q92674,Q92747,Q92783,Q92888,Q92974,Q93008,Q96AC1,Q96CS3,Q96DH6,Q96EA4,Q96EE3,Q96F07,Q96FJ2,Q96HY6,Q96JJ3,Q96KM6,Q96N67,Q96T58,Q99570,Q99661,Q99707,Q99832,Q9BSJ8,Q9BT78,Q9BTT6,Q9BUF5,Q9BVA1,Q9BW27,Q9BX68,Q9BXB4,Q9BZD4,Q9H0B6,Q9H0H5,Q9H2G2,Q9HBM1,Q9HD26,Q9NNW5,Q9NQS7,Q9NQW6,Q9NRG9,Q9NSV4,Q9NYL9,Q9NZQ3,Q9P0I2,Q9P258,Q9P2R3,Q9UDY2,Q9UEY8,Q9UH62,Q9UM54,Q9UNZ2,Q9UQB8,Q9Y266,Q9Y2A7,Q9Y2I1,Q9Y2U8,Q9Y3B8,Q9Y512,Q9Y6G9,Q9Y6M7 Antigen processing cross presentation 51 77 4.787461093819475 2.016941572731163e-11 3.677400448886586e-10 O00161,O00231,O00232,O00487,O14818,O15111,O43242,O75396,O75832,P01889,P04439,P09429,P10321,P17980,P20618,P25786,P25787,P25788,P25789,P27797,P28066,P28070,P28072,P28074,P30101,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60468,P60900,P61289,P61619,P62191,P62195,P62333,Q03518,Q06323,Q12846,Q13200,Q14997,Q15008,Q92530,Q99436,Q99460,Q9UIQ6,Q9UL46,Q9UNM6 Abc family proteins mediated transport 50 75 4.880353501019714 2.2054152657857274e-11 3.974817398565541e-10 O00231,O00232,O00487,O14818,O43242,O75027,O75477,O75832,O94905,P05198,P08183,P17980,P20042,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P28288,P35998,P40855,P43686,P48556,P49720,P49721,P51665,P55036,P55072,P60900,P61289,P62191,P62195,P62333,Q06323,Q13200,Q14997,Q15008,Q8NE71,Q92530,Q99436,Q99460,Q9BUN8,Q9NRK6,Q9UBV2,Q9UL46,Q9UNM6 Er to golgi anterograde transport 74 129 3.2963175275718113 2.4771366039836516e-11 4.4138070398254155e-10 O00743,O14579,O15020,O15027,O15498,O43237,O60763,O75396,O75935,O94979,O95249,O95486,O95487,P04350,P18085,P24390,P35606,P46459,P47755,P47756,P48444,P49257,P49755,P52907,P53618,P53621,P53634,P53992,P54920,P61163,P61923,P62820,P63167,P68371,P83436,P84085,Q01082,Q08379,Q12907,Q12955,Q13190,Q13409,Q13561,Q13813,Q13885,Q14203,Q14204,Q14789,Q15363,Q15436,Q5H9R7,Q5JRA6,Q8IUR0,Q8N6T3,Q8WVM8,Q92538,Q92734,Q96FJ2,Q96PC5,Q99747,Q9BUF5,Q9BVA1,Q9BVK6,Q9H0U4,Q9HCU5,Q9NZ32,Q9UBF2,Q9UJW0,Q9Y296,Q9Y3B3,Q9Y678,Q9Y6B6,Q9Y6G9,Q9Y6Y8 Nuclear pore complex npc disassembly 30 36 12.150573936529373 2.560982653564846e-11 4.5054651229995e-10 O15504,O75694,P06493,P12270,P14635,P35658,P37198,P49790,P49792,P52948,P57740,P78406,Q12769,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TD19,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7 Nuclear envelope ne reassembly 48 71 5.090500945179584 2.586045032333897e-11 4.5054651229995e-10 O75531,O75694,P02545,P04350,P06493,P14635,P18754,P20700,P30153,P37198,P42166,P42167,P46060,P50402,P52948,P53990,P57740,P62826,P63151,P68371,Q12769,Q13885,Q14739,Q14974,Q5SRE5,Q7Z3B4,Q86XL3,Q8IXJ6,Q8N1F7,Q8NC56,Q8NFH3,Q8NFH4,Q8NFH5,Q8WUM0,Q8WUX9,Q8WYP5,Q92621,Q92973,Q96EE3,Q99986,Q9BTX1,Q9BUF5,Q9BVA1,Q9BVL2,Q9BW27,Q9UN37,Q9UQN3,Q9Y2U8 Regulation of glucokinase by glucokinase regulatory protein 27 31 16.39123102866779 3.250895323724511e-11 5.601542711648388e-10 O15504,O75694,P12270,P35658,P37198,P49790,P49792,P52948,P57740,P78406,Q12769,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7 Regulation of runx2 expression and activity 43 61 5.821144644135488 3.3277400436116327e-11 5.671626509112e-10 O00231,O00232,O00487,O14818,O43242,O75832,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P42224,P43686,P48556,P49720,P49721,P49841,P51665,P55036,P60900,P61289,P62191,P62195,P62333,P63208,Q06323,Q13200,Q13309,Q13616,Q14997,Q15008,Q92530,Q99436,Q99460,Q9UL46,Q9UNE7,Q9UNM6 Mitotic prophase 58 93 4.049099230694322 3.458723675884624e-11 5.831482498695796e-10 O15504,O60763,O75531,O75694,O95347,P02545,P06493,P12270,P14635,P16104,P20700,P27361,P28482,P30153,P30154,P35658,P37198,P42166,P42167,P42695,P49790,P49792,P50402,P52948,P53350,P57740,P61019,P62805,P62820,P78406,Q01105,Q08379,Q12769,Q14980,Q5SRE5,Q7Z3B4,Q86XI2,Q8N1F7,Q8NC56,Q8NFH3,Q8NFH4,Q8NFH5,Q8TD19,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q99567,Q99986,Q9BTX1,Q9BVL2,Q9BW27,Q9H0U4,Q9H8Y8,Q9NRG9,Q9NTJ3,Q9UKX7,Q9Y2U8 Sumoylation of dna replication proteins 35 46 7.739877640114367 6.931119142614586e-11 1.1561696612361353e-09 O14965,O15504,O75694,P11387,P11388,P12004,P12270,P35658,P37198,P46060,P49790,P49792,P52948,P57740,P78406,Q02880,Q12769,Q53HL2,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9NQS7,Q9NRG9,Q9UKX7 Apoptosis 85 159 2.817290975185712 1.296253651044661e-10 2.1395007629873983e-09 O00231,O00232,O00273,O00429,O00487,O14818,O43242,O60313,O75832,P02545,P04637,P07305,P08670,P09429,P10412,P15924,P16402,P16403,P17980,P20618,P20700,P25786,P25787,P25788,P25789,P26583,P27348,P27361,P28066,P28070,P28072,P28074,P28482,P30419,P31751,P31946,P35222,P35611,P35998,P40763,P43686,P48556,P49327,P49720,P49721,P51572,P51665,P52294,P55036,P60900,P61289,P61981,P62191,P62195,P62258,P62333,P63104,P63167,Q04917,Q06323,Q07021,Q07157,Q13177,Q13200,Q13464,Q13546,Q13813,Q14126,Q14974,Q14997,Q15008,Q15149,Q16625,Q92530,Q96FJ2,Q99436,Q99460,Q9NR28,Q9P289,Q9UDY2,Q9UJU6,Q9UKV3,Q9UL46,Q9UNM6,Q9Y3B8 Abc transporter disorders 42 61 5.383942908117752 1.8639567691785918e-10 3.0444627229917003e-09 O00231,O00232,O00487,O14818,O43242,O75477,O75832,O94905,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P55072,P60900,P61289,P62191,P62195,P62333,Q06323,Q13200,Q14997,Q15008,Q92530,Q99436,Q99460,Q9BUN8,Q9UBV2,Q9UL46,Q9UNM6 Mapk6 mapk4 signaling 49 77 4.267074413863405 4.1738864901073865e-10 6.747065996379776e-09 O00231,O00232,O00487,O14818,O14980,O43242,O75832,P04792,P06493,P17612,P17980,P20618,P25685,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P60953,P61289,P62191,P62195,P62333,P63000,Q06323,Q13177,Q13200,Q14997,Q15008,Q16181,Q16512,Q92530,Q99436,Q99460,Q9HCE1,Q9NZI8,Q9UL46,Q9UNM6 Asymmetric localization of pcp proteins 38 54 5.779113067027759 5.090345485300434e-10 8.144552776480695e-09 O00231,O00232,O00487,O14818,O43242,O75832,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,Q06323,Q13200,Q14160,Q14997,Q15008,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Pyruvate metabolism and citric acid tca cycle 35 48 6.547306261543664 5.165466868183953e-10 8.181264696275191e-09 O00330,O43708,O43837,O75390,O95563,P00338,P07195,P07954,P08559,P09622,P10515,P11177,P21796,P21912,P23368,P31040,P35613,P36957,P40926,P48163,P48735,P50213,P53597,P53985,Q02218,Q04760,Q13423,Q15118,Q15120,Q6P587,Q8NCN5,Q96I99,Q99798,Q9H9P8,Q9P2R7 Cytokine signaling in immune system 171 392 1.915326390147584 6.611008189988073e-10 1.0366060841901298e-08 O00170,O00231,O00232,O00487,O00505,O14818,O14979,O15111,O15344,O15504,O43242,O43432,O60573,O75369,O75694,O75832,P01889,P04083,P04179,P04439,P04637,P05067,P05388,P05556,P06730,P07237,P07355,P07900,P08670,P09429,P09601,P09661,P10321,P11142,P11233,P12270,P14174,P14625,P17612,P17980,P17987,P18031,P19174,P19474,P19525,P20618,P20700,P21333,P22626,P22681,P23528,P25786,P25787,P25788,P25789,P26038,P27361,P27824,P28066,P28070,P28072,P28074,P28482,P29372,P30153,P30154,P31751,P35658,P35998,P37198,P37837,P38646,P38919,P40222,P40763,P41240,P42224,P43686,P46108,P46109,P48556,P49720,P49721,P49790,P49792,P51452,P51532,P51665,P51809,P51812,P52292,P52294,P52597,P52907,P52948,P55036,P55265,P57740,P60842,P60900,P60953,P61081,P61088,P61221,P61289,P62191,P62195,P62333,P62993,P63104,P63208,P78344,P78406,P78417,Q02750,Q04637,Q06124,Q06323,Q07820,Q12769,Q12846,Q12899,Q13126,Q13177,Q13200,Q13325,Q13526,Q13555,Q13616,Q14240,Q14258,Q14738,Q14974,Q14997,Q15008,Q15369,Q15370,Q15418,Q15750,Q16539,Q16658,Q53EL6,Q5SRE5,Q6L8Q7,Q7Z3B4,Q8IV63,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TBC4,Q8TEM1,Q8WUM0,Q92530,Q92621,Q93034,Q96EE3,Q99436,Q99439,Q99460,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9H3K6,Q9NRG9,Q9UKX7,Q9UL46,Q9UNM6,Q9Y3Z3,Q9Y4X5 Pcp ce pathway 49 78 4.119359790033627 8.044657504760149e-10 1.2489131650954371e-08 O00231,O00232,O00487,O14818,O43242,O75832,O94973,O95782,P07737,P09496,P09497,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P53680,P55036,P60900,P61289,P61586,P62191,P62195,P62333,P63000,P63010,Q00610,Q06323,Q13200,Q14160,Q14997,Q15008,Q92530,Q96CW1,Q99436,Q99460,Q9UL46,Q9UNM6 Hiv life cycle 77 144 2.8137989298789075 9.45933797084378e-10 1.4541413664983379e-08 O00267,O14980,O15504,O15514,O43148,O75351,O75475,O75531,O75694,P12270,P12956,P13010,P17096,P18074,P18615,P18754,P18858,P19387,P19388,P19447,P23193,P24928,P29083,P30419,P30876,P35269,P35658,P37198,P39748,P43487,P46060,P49790,P49792,P50750,P52294,P52948,P57740,P62487,P62826,P62875,P78406,Q00403,Q08945,Q09161,Q12769,Q14241,Q15369,Q15370,Q5SRE5,Q7Z3B4,Q8IXH7,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q8WUM4,Q8WUX9,Q8WX92,Q92621,Q92804,Q96EE3,Q99567,Q99816,Q9BTX1,Q9BVL2,Q9BW27,Q9H3P2,Q9H9H4,Q9NP79,Q9NRG9,Q9NZZ3,Q9UKX7,Q9UN37,Q9UQN3,Q9Y5B9 Cellular response to hypoxia 40 59 5.124090714591357 1.0453467826105678e-09 1.5913628690615247e-08 O00231,O00232,O00487,O14818,O43242,O75832,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,Q06323,Q13200,Q13617,Q14997,Q15008,Q15369,Q15370,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Degradation of beta catenin by the destruction complex 48 77 4.0339205397301345 1.7478347053470568e-09 2.622055287892064e-08 O00231,O00232,O00487,O14818,O43242,O75832,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P30153,P30154,P35222,P35998,P43686,P48556,P48729,P49720,P49721,P49841,P51665,P55036,P56545,P60900,P61289,P62191,P62195,P62333,P63208,Q06323,Q13200,Q13363,Q13547,Q13616,Q14738,Q14997,Q15008,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Mitotic g1 phase and g1 s transition 76 143 2.7763036668509304 1.7558405945705786e-09 2.622055287892064e-08 O00231,O00232,O00487,O14818,O43242,O43913,O75419,O75832,P00374,P04183,P04818,P06493,P09884,P11388,P11802,P12004,P14635,P15927,P17980,P20618,P24941,P25205,P25786,P25787,P25788,P25789,P27694,P28066,P28070,P28072,P28074,P30153,P30154,P31350,P31751,P33991,P33992,P33993,P35244,P35998,P43686,P48556,P49642,P49643,P49720,P49721,P49736,P51665,P55036,P60900,P61289,P62191,P62195,P62333,P63151,P63208,Q00534,Q06323,Q07864,Q13200,Q13309,Q13547,Q13616,Q14181,Q14566,Q15008,Q7L590,Q92530,Q99436,Q99460,Q9NR33,Q9NRF9,Q9UBD5,Q9UL46,Q9UNM6,Q9Y619 Gene silencing by rna 47 75 4.090128547174388 2.0059610678552344e-09 2.9673084475443465e-08 O15397,O15504,O15514,O75569,O75694,P07900,P12270,P16104,P19387,P19388,P24928,P30876,P35658,P37198,P49790,P49792,P52948,P57740,P62487,P62805,P62826,P62875,P78406,Q12769,Q15631,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q8WYQ5,Q92621,Q96EE3,Q99567,Q99598,Q9BQ52,Q9BTX1,Q9BVL2,Q9BW27,Q9HAV4,Q9NRG9,Q9UKX7,Q9UPY3,Q9Y2W6 Trna processing in the nucleus 40 60 4.867208672086721 2.2498747858223754e-09 3.2970127702518546e-08 O15504,O43592,O75694,P12270,P33240,P35658,P37198,P49790,P49792,P52948,P57740,P62826,P78346,P78406,Q10570,Q12769,Q52LJ0,Q5KU26,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92499,Q92621,Q96EE3,Q99567,Q99575,Q9BQ52,Q9BTX1,Q9BVC5,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7,Q9Y224,Q9Y3I0 Postmitotic nuclear pore complex npc reformation 23 27 13.944088918827887 2.5243822813018278e-09 3.665029089890061e-08 O75694,P18754,P37198,P46060,P52948,P57740,P62826,Q12769,Q14974,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8WUM0,Q8WYP5,Q92621,Q92973,Q96EE3,Q9BTX1,Q9BVL2,Q9BW27 Rhobtb2 gtpase cycle 20 22 24.2328398384926 2.5806486424310535e-09 3.6785973375744474e-08 O43396,P07900,P07910,P08238,P12814,P38159,P40227,P62995,P78371,Q12792,Q13618,Q13838,Q16543,Q16643,Q8IYB3,Q8WWQ0,Q96DH6,Q99832,Q9NYL9,Q9UM54 Rhobtb1 gtpase cycle 20 22 24.2328398384926 2.5806486424310535e-09 3.6785973375744474e-08 O43396,O75116,P07910,P08670,P38159,P61201,P62995,P78371,Q13098,Q13464,Q13618,Q16643,Q5VTR2,Q7Z6E9,Q8IYB3,Q8N684,Q96T58,Q99832,Q9BT78,Q9UM54 Copi mediated anterograde transport 53 89 3.5906392953007447 2.6830609389226565e-09 3.790125722730383e-08 O14579,O15020,O15498,O43237,O60763,O75935,O95249,P04350,P18085,P24390,P35606,P46459,P47755,P47756,P48444,P49755,P52907,P53618,P53621,P54920,P61163,P61923,P62820,P63167,P68371,P83436,P84085,Q01082,Q08379,Q12955,Q13190,Q13409,Q13561,Q13813,Q13885,Q14203,Q14204,Q14789,Q15363,Q8N6T3,Q92538,Q96FJ2,Q99747,Q9BUF5,Q9BVA1,Q9BVK6,Q9H0U4,Q9NZ32,Q9UBF2,Q9UJW0,Q9Y3B3,Q9Y678,Q9Y6G9 Mrna decay by 3 to 5 exoribonuclease 16 16 inf 2.9388252152872163e-09 4.114355301402103e-08 Q06265,Q13868,Q15024,Q15477,Q5RKV6,Q6PGP7,Q969T7,Q96B26,Q96C86,Q9GZS3,Q9NPD3,Q9NQT4,Q9NQT5,Q9Y2L1,Q9Y3B2,Q9Y450 Regulation of runx3 expression and activity 36 52 5.4712449255751014 2.9772030138144094e-09 4.131198518284065e-08 O00231,O00232,O00487,O14818,O43242,O75832,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,Q06323,Q13200,Q15008,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Regulation of pten stability and activity 41 63 4.535627368226487 4.216984600766907e-09 5.8002033807039565e-08 O00231,O00232,O00487,O14818,O43242,O75832,P17980,P19784,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P31751,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,P67870,Q06323,Q13200,Q14997,Q15008,Q92530,Q99436,Q99460,Q9UL46,Q9UNE7,Q9UNM6 G1 s dna damage checkpoints 40 61 4.634791586011098 4.689081341100675e-09 6.338344433487809e-08 O00231,O00232,O00487,O14818,O43242,O75832,O96017,P04637,P17980,P20618,P24941,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,Q06323,Q13200,Q14997,Q15008,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Cellular response to chemical stress 71 133 2.799980121699374 4.666951531451194e-09 6.338344433487809e-08 O00231,O00232,O00483,O00487,O14818,O43242,O43819,O75832,O75880,P00390,P00403,P04179,P07237,P09601,P09669,P10606,P13073,P15954,P17980,P19784,P20618,P20674,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P30041,P30044,P30048,P30519,P32119,P35998,P40763,P42704,P43686,P48556,P49720,P49721,P51665,P53004,P55036,P60900,P61289,P62191,P62195,P62333,P63208,P67870,Q06323,Q13200,Q13309,Q13616,Q13618,Q14997,Q15008,Q15648,Q16881,Q86X55,Q8TCT9,Q8TED1,Q92530,Q96HE7,Q96ST3,Q99436,Q99460,Q9UL46,Q9UNM6 Transcriptional regulation by small rnas 38 57 4.8645903859174 5.6815913942249174e-09 7.486332190037539e-08 O15397,O15504,O15514,O75694,P12270,P16104,P19387,P19388,P24928,P30876,P35658,P37198,P49790,P49792,P52948,P57740,P62487,P62805,P62826,P62875,P78406,Q12769,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7 Deadenylation dependent mrna decay 38 57 4.8645903859174 5.6815913942249174e-09 7.486332190037539e-08 A5YKK6,O95453,P06730,P11940,P23588,P26196,P38919,P60842,P62312,Q04637,Q06265,Q13868,Q14240,Q15024,Q15477,Q5RKV6,Q6P2E9,Q6PGP7,Q86TB9,Q92600,Q969T7,Q96B26,Q96C86,Q96F86,Q9C0C2,Q9GZS3,Q9H074,Q9HBH5,Q9NPD3,Q9NQT4,Q9NQT5,Q9UIV1,Q9UK45,Q9Y2L1,Q9Y333,Q9Y3B2,Q9Y450,Q9Y4Z0 Regulation of ras by gaps 38 57 4.8645903859174 5.6815913942249174e-09 7.486332190037539e-08 O00231,O00232,O00487,O14818,O43242,O75832,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,Q06323,Q13200,Q13618,Q14997,Q15008,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Sumoylation of sumoylation proteins 27 35 8.19106239460371 6.517319995450773e-09 8.515964794055676e-08 O15504,O75694,P12270,P35658,P37198,P49790,P49792,P52948,P57740,P78406,Q12769,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7 Asparagine n linked glycosylation 114 245 2.1386830337013087 6.6956136671909085e-09 8.668025365847933e-08 O00743,O14579,O15020,O15027,O15498,O43237,O60762,O60763,O75340,O75396,O75935,O94979,O95249,O95394,O95486,O95487,P04066,P04350,P04843,P04844,P10619,P14314,P16278,P18085,P24390,P27797,P27824,P30101,P34949,P35606,P39656,P46459,P46977,P47755,P47756,P48444,P49257,P49755,P52907,P53618,P53621,P53634,P53992,P54727,P54920,P55072,P61163,P61803,P61923,P62191,P62820,P63167,P68371,P83436,P84085,Q01082,Q04323,Q06210,Q08379,Q12907,Q12955,Q13190,Q13409,Q13561,Q13630,Q13724,Q13813,Q13885,Q14165,Q14203,Q14204,Q14697,Q14789,Q15363,Q15436,Q16222,Q16706,Q2TAA5,Q5H9R7,Q5JRA6,Q86YN1,Q8IUR0,Q8N6T3,Q8NFW8,Q8WVM8,Q92538,Q92734,Q96FJ2,Q96IJ6,Q96PC5,Q99747,Q9BT22,Q9BUF5,Q9BUN8,Q9BVA1,Q9BVK6,Q9H0U3,Q9H0U4,Q9HCU5,Q9NR45,Q9NYU2,Q9NZ32,Q9UBF2,Q9UBV2,Q9UJ70,Q9UJW0,Q9Y296,Q9Y3B3,Q9Y5P6,Q9Y673,Q9Y678,Q9Y6B6,Q9Y6G9,Q9Y6Y8 Mitochondrial translation 54 93 3.3767083835157354 6.7442544300602546e-09 8.668025365847933e-08 O75616,P09001,P43897,P49406,P49411,P51398,P52815,P82650,P82663,P82673,P82675,P82912,P82914,P82930,P82933,Q13084,Q13405,Q14197,Q15070,Q6P1L8,Q7Z2W9,Q7Z7H8,Q8N5N7,Q8N983,Q8TAE8,Q92552,Q92665,Q96A35,Q96DV4,Q96EL3,Q96EY7,Q96GC5,Q96RP9,Q9BRJ2,Q9BYC9,Q9BYD1,Q9BYD2,Q9BYD6,Q9BZE1,Q9H2W6,Q9H9J2,Q9HD33,Q9NP92,Q9NQ50,Q9NRX2,Q9NYK5,Q9P015,Q9Y2Q9,Q9Y2R5,Q9Y2R9,Q9Y399,Q9Y3B7,Q9Y3D3,Q9Y3D9 Cytoprotection by hmox1 61 110 3.0389781296346583 8.376164711457735e-09 1.0677907534606284e-07 O00231,O00232,O00483,O00487,O14818,O43242,O43819,O75832,O75880,P00403,P09601,P09669,P10606,P13073,P15954,P17980,P19784,P20618,P20674,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P30519,P35998,P40763,P42704,P43686,P48556,P49720,P49721,P51665,P53004,P55036,P60900,P61289,P62191,P62195,P62333,P63208,P67870,Q06323,Q13200,Q13309,Q13616,Q13618,Q14997,Q15008,Q15648,Q86X55,Q8TCT9,Q92530,Q96ST3,Q99436,Q99460,Q9UL46,Q9UNM6 Resolution of ap sites via the multiple nucleotide patch replacement pathway 23 28 11.153721791849108 1.0192368369982361e-08 1.288841419688092e-07 P09874,P12004,P15927,P18858,P27694,P27695,P28340,P35244,P35249,P35250,P35251,P39748,P40937,P40938,P41440,P49005,Q07864,Q86W56,Q9NR33,Q9NRF9,Q9NX46,Q9UGN5,Q9Y2S7 Transport to the golgi and subsequent modification 76 148 2.5816948635878676 1.302429531276359e-08 1.6337676040330648e-07 O00743,O14579,O15020,O15027,O15498,O43237,O60763,O75396,O75935,O94979,O95249,O95486,O95487,P04066,P04350,P18085,P24390,P35606,P46459,P47755,P47756,P48444,P49257,P49755,P52907,P53618,P53621,P53634,P53992,P54920,P61163,P61923,P62820,P63167,P68371,P83436,P84085,Q01082,Q08379,Q12907,Q12955,Q13190,Q13409,Q13561,Q13813,Q13885,Q14203,Q14204,Q14789,Q15363,Q15436,Q16706,Q5H9R7,Q5JRA6,Q8IUR0,Q8N6T3,Q8WVM8,Q92538,Q92734,Q96FJ2,Q96PC5,Q99747,Q9BUF5,Q9BVA1,Q9BVK6,Q9H0U4,Q9HCU5,Q9NZ32,Q9UBF2,Q9UJW0,Q9Y296,Q9Y3B3,Q9Y678,Q9Y6B6,Q9Y6G9,Q9Y6Y8 Lagging strand synthesis 20 23 16.152983400628084 1.429051993628115e-08 1.7783758142927653e-07 P09884,P12004,P15927,P18858,P27694,P28340,P35244,P35249,P35250,P35251,P39748,P40937,P40938,P41440,P49005,P49642,P49643,P51530,Q14181,Q9Y2S7 Rho gtpase effectors 113 246 2.086728631234216 1.9063461197258242e-08 2.3536619808898364e-07 O00139,O14974,O14980,O15143,O15144,O15145,O43237,O43264,O43663,O43684,O60341,O60566,O60610,O75116,O75122,P04350,P05556,P07737,P16104,P21333,P23528,P27348,P27361,P28482,P30153,P30154,P31946,P33176,P35080,P35221,P35222,P35579,P35580,P43034,P46060,P46940,P49792,P50748,P52948,P53350,P57740,P59998,P60660,P60953,P61158,P61160,P61586,P61981,P62140,P62258,P62805,P62993,P63000,P63104,P63167,P68371,P84095,Q04917,Q07866,Q12769,Q13177,Q13257,Q13409,Q13464,Q13526,Q13576,Q13885,Q14008,Q14204,Q14247,Q14738,Q15005,Q15058,Q15334,Q15691,Q16512,Q16513,Q16539,Q2NKX8,Q53HL2,Q7L576,Q7Z406,Q7Z460,Q86UP2,Q8NBT2,Q8NFH3,Q8NFH4,Q8WUM0,Q8WYP5,Q92674,Q92747,Q96EA4,Q96EE3,Q96F07,Q96FJ2,Q99570,Q99661,Q9BUF5,Q9BVA1,Q9BW27,Q9BZD4,Q9H0B6,Q9HBM1,Q9HD26,Q9NQS7,Q9NSV4,Q9NZQ3,Q9P258,Q9UQB8,Q9Y266,Q9Y2A7,Q9Y3B8,Q9Y6G9 Fceri mediated nf kb activation 42 68 3.930586701434159 2.6832125055336512e-08 3.286935319278723e-07 O00231,O00232,O00487,O14818,O15111,O43242,O75832,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61088,P61289,P62191,P62195,P62333,P63208,Q06323,Q13200,Q13616,Q14997,Q15008,Q15750,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Intra golgi and retrograde golgi to er traffic 88 181 2.3170413815575106 2.8625509933006894e-08 3.479441827515877e-07 A2RRP1,O00139,O00461,O14579,O15260,O15498,O43237,O43264,O60664,O75396,O75935,O95235,O95239,O95249,P04350,P11717,P18085,P20645,P24390,P33176,P35606,P40616,P43034,P46459,P47755,P47756,P48444,P49755,P51151,P52732,P52907,P53618,P53621,P54920,P61163,P61923,P62820,P63167,P68371,P68402,P83436,P84085,Q02241,Q07866,Q10471,Q10472,Q12756,Q12981,Q13190,Q13409,Q13561,Q13885,Q14203,Q14204,Q14807,Q15042,Q15102,Q15363,Q16706,Q5VIR6,Q5VZE5,Q6NUQ1,Q8IWJ2,Q8N6T3,Q8TBA6,Q8TD16,Q92538,Q96FJ2,Q99661,Q99747,Q9BUF5,Q9BVA1,Q9BVK6,Q9BW19,Q9H0B6,Q9H0H5,Q9H0U4,Q9H2M9,Q9NP72,Q9NZ32,Q9P2W9,Q9UBF2,Q9UID3,Q9UJW0,Q9Y3B3,Q9Y496,Q9Y678,Q9Y6G9 Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 62 116 2.801794969030464 4.1330064631098064e-08 4.985041641658598e-07 O00217,O00483,O14949,O43674,O43676,O43678,O43819,O75251,O75306,O75380,O75489,O75880,O75947,O75964,O95168,O95182,O95299,O96000,P00403,P03886,P06576,P08574,P09669,P10606,P13073,P13804,P14927,P15954,P19404,P20674,P21912,P22695,P24539,P25705,P28331,P31040,P31930,P36542,P38117,P42704,P48047,P49821,P51970,P56134,P56385,Q12931,Q16134,Q16718,Q16795,Q7L592,Q86Y39,Q8N183,Q8TB37,Q9BQ95,Q9BU61,Q9H845,Q9NPL8,Q9NX14,Q9P032,Q9P0J0,Q9UDW1,Q9Y6M9 Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand 32 47 5.181261261261262 4.262232409720498e-08 5.10166444155858e-07 O43237,O60884,O75935,P04350,P07900,P08238,P0DMV9,P11142,P25685,P31689,P31948,P47755,P47756,P52907,P54652,P61163,P63167,P68371,Q02790,Q13409,Q13451,Q13561,Q13885,Q14203,Q14204,Q15185,Q96FJ2,Q9BUF5,Q9BVA1,Q9NZ32,Q9UJW0,Q9Y6G9 Gene and protein expression by jak stat signaling after interleukin 12 stimulation 25 33 7.579204583754635 4.5569167395021564e-08 5.41306473298438e-07 O00170,O14979,P04179,P05388,P07355,P09661,P11233,P14174,P17987,P20700,P22626,P23528,P26038,P37837,P38646,P52597,P52907,P60953,P78417,Q13126,Q13177,Q53EL6,Q99439,Q9H3K6,Q9UL46 Metabolism of carbohydrates 95 201 2.1958629942490933 4.739872439530459e-08 5.587099541188912e-07 A6NDG6,O00754,O15504,O43252,O43505,O75330,O75694,O75746,O95336,P00505,P00558,P04075,P04406,P06733,P06737,P06744,P06865,P07686,P08236,P08237,P09972,P10253,P11166,P11216,P11413,P11498,P11908,P12270,P13807,P14550,P14618,P15121,P15586,P16278,P17174,P17612,P17858,P18669,P19367,P29401,P30153,P30154,P35573,P35658,P36871,P37198,P37837,P40925,P40926,P46926,P46976,P49790,P49792,P51570,P52209,P52789,P52948,P53007,P54802,P57740,P60174,P78406,Q00796,Q01813,Q02978,Q12769,Q14738,Q16822,Q16851,Q5SRE5,Q7LGA3,Q7Z3B4,Q7Z4W1,Q8N1F7,Q8NCH0,Q8NFH3,Q8NFH4,Q8NFH5,Q8TB61,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q96G03,Q96L58,Q99567,Q9BRR6,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UBX3,Q9UHD1,Q9UJS0,Q9UKX7 Interleukin 12 family signaling 30 43 5.6025035059471255 4.7746896589241974e-08 5.587099541188912e-07 O00170,O14979,P04179,P05388,P07237,P07355,P09661,P11233,P14174,P17987,P20700,P22626,P23528,P26038,P27824,P37837,P38646,P40763,P42224,P51809,P52597,P52907,P60953,P78417,Q13126,Q13177,Q53EL6,Q99439,Q9H3K6,Q9UL46 Copi dependent golgi to er retrograde traffic 48 83 3.3395962732919253 5.5171055953579904e-08 6.408015980386169e-07 A2RRP1,O00139,O14579,O15260,O43264,O75396,O95235,O95239,P04350,P18085,P24390,P33176,P35606,P46459,P48444,P49755,P52732,P53618,P53621,P54920,P61923,P62820,P68371,P84085,Q02241,Q07866,Q12756,Q12981,Q13885,Q14807,Q15363,Q6NUQ1,Q8N6T3,Q92538,Q99661,Q99747,Q9BUF5,Q9BVA1,Q9BVK6,Q9BW19,Q9H0B6,Q9H0H5,Q9H0U4,Q9P2W9,Q9UBF2,Q9Y3B3,Q9Y496,Q9Y678 Mitotic g2 g2 m phases 89 186 2.2462472167079204 6.151176327170603e-08 7.091944471326107e-07 O00231,O00232,O00487,O14818,O14965,O14974,O14980,O43242,O43805,O75330,O75832,O75935,O94927,O95684,P04350,P04637,P06493,P07437,P07900,P08238,P14635,P17612,P17980,P20618,P24941,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P30153,P30154,P35998,P41208,P43034,P43686,P48556,P49720,P49721,P51665,P53350,P55036,P60900,P61006,P61163,P61289,P61981,P62140,P62191,P62195,P62258,P62333,P63151,P63167,P63208,P68371,Q06323,Q13200,Q13409,Q13561,Q13616,Q13885,Q14008,Q14203,Q14204,Q14997,Q15008,Q15154,Q15691,Q68CZ6,Q7Z460,Q7Z4H7,Q92530,Q96CS2,Q96CW5,Q99436,Q99460,Q99640,Q9BSJ2,Q9BUF5,Q9BVA1,Q9H6D7,Q9UL46,Q9ULW0,Q9UNM6,Q9Y570 Mhc class ii antigen presentation 55 100 2.9791926758218894 6.589894926256304e-08 7.542303098080207e-07 O00139,O15020,O43237,O43747,O75935,O94973,O94979,O95235,O95239,O95486,O95487,O95782,P04350,P09496,P10619,P27824,P33176,P47755,P47756,P50570,P51149,P52732,P52907,P53634,P53680,P53992,P61163,P63010,P63167,P68371,Q00610,Q02241,Q07866,Q10567,Q13409,Q13561,Q13885,Q14203,Q14204,Q14807,Q15436,Q96CW1,Q96FJ2,Q99538,Q99661,Q9BUF5,Q9BVA1,Q9BXS5,Q9H0B6,Q9H0H5,Q9NZ32,Q9UJW0,Q9Y496,Q9Y6B6,Q9Y6G9 Hedgehog on state 42 70 3.648813559322034 8.827088305020447e-08 1.0029619175559465e-06 O00231,O00232,O00487,O14818,O43242,O75832,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P48729,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,Q06323,Q13200,Q13618,Q14997,Q15008,Q6P1J9,Q92530,Q96J02,Q99436,Q99460,Q9UL46,Q9UNM6,Q9Y496 Runx1 regulates transcription of genes involved in differentiation of hscs 41 68 3.6931234860750277 1.036084105443266e-07 1.1687625016798858e-06 O00231,O00232,O00487,O14818,O43242,O75832,P16104,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,P62805,Q03164,Q06323,Q13200,Q14997,Q15008,Q92530,Q96J02,Q99436,Q99460,Q9UL46,Q9UNM6 Post translational protein modification 367 1003 1.4438191075172206 1.1266244917748905e-07 1.2618194307878773e-06 A0AVT1,O00231,O00232,O00487,O00743,O14579,O14818,O14964,O14965,O15020,O15027,O15294,O15498,O15504,O43237,O43242,O43292,O43505,O43681,O43852,O60216,O60493,O60678,O60725,O60762,O60763,O60826,O60870,O75150,O75340,O75381,O75396,O75694,O75832,O75935,O76024,O94826,O94888,O94966,O94979,O95249,O95394,O95486,O95487,O95630,O96019,P04066,P04350,P04439,P04637,P04843,P04844,P05067,P06493,P06748,P07237,P07910,P09874,P10619,P11142,P11387,P11388,P12004,P12270,P13639,P14314,P14625,P14735,P15880,P16278,P17844,P17980,P18085,P19022,P20338,P20339,P20618,P21796,P22314,P24390,P25786,P25787,P25788,P25789,P26358,P27694,P27797,P27824,P28066,P28070,P28072,P28074,P30101,P34949,P35606,P35658,P35998,P37198,P38117,P38398,P38435,P39656,P41208,P43686,P45880,P45973,P45974,P46060,P46459,P46977,P47755,P47756,P48444,P48556,P49257,P49366,P49720,P49721,P49755,P49790,P49792,P50542,P51148,P51149,P51151,P51153,P51610,P51665,P51784,P52907,P52948,P53618,P53621,P53634,P53992,P54132,P54578,P54727,P54920,P55036,P55072,P57740,P60900,P61006,P61019,P61020,P61026,P61081,P61086,P61088,P61106,P61163,P61201,P61289,P61586,P61803,P61923,P61962,P61964,P61978,P62191,P62195,P62333,P62805,P62820,P63167,P63208,P63241,P68036,P68371,P78406,P78527,P83436,P84085,Q01082,Q02818,Q02880,Q04323,Q06210,Q06323,Q07065,Q08379,Q10471,Q10472,Q12769,Q12888,Q12907,Q12955,Q13098,Q13190,Q13200,Q13217,Q13263,Q13309,Q13330,Q13363,Q13409,Q13546,Q13547,Q13561,Q13564,Q13616,Q13617,Q13618,Q13620,Q13630,Q13724,Q13813,Q13885,Q14165,Q14166,Q14203,Q14204,Q14258,Q14318,Q14527,Q14676,Q14683,Q14694,Q14697,Q14789,Q14997,Q15008,Q15018,Q15022,Q15084,Q15286,Q15291,Q15293,Q15363,Q15369,Q15370,Q15388,Q15424,Q15436,Q15750,Q16186,Q16222,Q16531,Q16706,Q16763,Q2TAA5,Q53HL2,Q5H9R7,Q5JRA6,Q5SRE5,Q5VTR2,Q6P1J9,Q6PD62,Q7L5N1,Q7Z3B4,Q7Z434,Q86UP2,Q86UV5,Q86VP6,Q86YN1,Q8IUR0,Q8IXI2,Q8IY18,Q8N1F7,Q8N3U4,Q8N6T3,Q8N7H5,Q8NB78,Q8NFH3,Q8NFH4,Q8NFH5,Q8NFW8,Q8TBC4,Q8TEM1,Q8WUM0,Q8WVM7,Q8WVM8,Q92530,Q92538,Q92621,Q92643,Q92696,Q92734,Q92769,Q92783,Q92841,Q92890,Q92905,Q93008,Q93009,Q93034,Q969N2,Q969Q5,Q96EE3,Q96FJ2,Q96FW1,Q96IJ6,Q96K76,Q96MG7,Q96PC5,Q96RU2,Q96S52,Q96SB8,Q96ST3,Q99436,Q99460,Q99497,Q99567,Q99627,Q99747,Q9BQC3,Q9BT22,Q9BT78,Q9BTE7,Q9BTX1,Q9BTY2,Q9BU89,Q9BUF5,Q9BUN8,Q9BVA1,Q9BVK6,Q9BVL2,Q9BW27,Q9BW61,Q9GZS3,Q9H0U3,Q9H0U4,Q9H2P9,Q9H490,Q9HA64,Q9HCU5,Q9NP72,Q9NQS7,Q9NR45,Q9NRG9,Q9NV06,Q9NWV8,Q9NXR7,Q9NYU2,Q9NZ32,Q9NZL9,Q9UBE0,Q9UBF2,Q9UBT2,Q9UBV2,Q9UBW8,Q9UJ70,Q9UJW0,Q9UKX7,Q9UL25,Q9UL46,Q9ULX3,Q9UNM6,Q9UNS2,Q9UPU5,Q9UQE7,Q9Y265,Q9Y277,Q9Y296,Q9Y2X3,Q9Y3B3,Q9Y3E5,Q9Y4A5,Q9Y5A7,Q9Y5K5,Q9Y5P6,Q9Y673,Q9Y678,Q9Y6B6,Q9Y6G9,Q9Y6Y8 Mitotic telophase cytokinesis 13 13 inf 1.1746243515166018e-07 1.3062489242397388e-06 O60216,O95235,P53350,Q02241,Q14683,Q29RF7,Q6KC79,Q7Z5K2,Q8N3U4,Q8WVM7,Q9NTI5,Q9UQE7,Q9Y6X3 Interleukin 12 signaling 27 38 5.954652767131688 1.243755652926566e-07 1.3733865237949686e-06 O00170,O14979,P04179,P05388,P07237,P07355,P09661,P11233,P14174,P17987,P20700,P22626,P23528,P26038,P37837,P38646,P51809,P52597,P52907,P60953,P78417,Q13126,Q13177,Q53EL6,Q99439,Q9H3K6,Q9UL46 Citric acid cycle tca cycle 18 21 14.527908540685944 1.2645100558319888e-07 1.3865396975836073e-06 O43837,O75390,P07954,P09622,P21912,P23368,P31040,P36957,P40926,P48735,P50213,P53597,Q02218,Q13423,Q6P587,Q96I99,Q99798,Q9P2R7 Protein localization 71 142 2.4419719274221157 1.5460101244920747e-07 1.6657391679667768e-06 O00116,O14734,O14925,O15228,O15254,O43615,O43681,O43765,O43808,O60830,O75381,O75390,O75431,O75439,O75521,O75746,O75874,O94826,O96008,P05067,P06576,P08574,P09110,P09601,P10809,P12235,P12236,P14735,P21796,P22307,P25705,P28288,P34913,P35914,P38646,P40855,P46379,P50402,P50542,P51648,P51659,P60468,Q10713,Q13011,Q13190,Q13505,Q15067,Q15388,Q3ZCQ8,Q5JRX3,Q5T8D3,Q7L5D6,Q8N4H5,Q8NBU5,Q8TB36,Q93008,Q99595,Q99798,Q9BY49,Q9HAV7,Q9NR77,Q9NS69,Q9NX63,Q9P0L0,Q9UJ83,Q9UJS0,Q9Y276,Q9Y2Q3,Q9Y512,Q9Y5J9,Q9Y5L4 Signaling by notch4 42 71 3.5225014611338397 1.551007133438453e-07 1.6657391679667768e-06 O00231,O00232,O00487,O14818,O43242,O75832,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,P63104,P63208,Q06323,Q13200,Q13573,Q13616,Q15008,Q92530,Q92542,Q99436,Q99460,Q9UL46,Q9UNM6,Q9Y6A5 Downstream signaling events of b cell receptor bcr 42 71 3.5225014611338397 1.551007133438453e-07 1.6657391679667768e-06 O00231,O00232,O00487,O14818,O15111,O43242,O75832,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,P62942,P63208,Q06323,Q08209,Q13200,Q13616,Q14997,Q15008,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Resolution of abasic sites ap sites 28 41 5.225474929928371 2.738157488684437e-07 2.9207013212633996e-06 P09874,P12004,P13051,P15927,P18858,P18887,P27694,P27695,P28340,P29372,P35244,P35249,P35250,P35251,P39748,P40937,P40938,P41440,P49005,P49916,Q07864,Q86W56,Q96T60,Q9NR33,Q9NRF9,Q9NX46,Q9UGN5,Q9Y2S7 Hedgehog off state 52 96 2.8781694495980212 2.882699343483795e-07 3.0541030882314804e-06 O00231,O00232,O00487,O14818,O43242,O75832,P04350,P10644,P13861,P17612,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P48729,P49720,P49721,P49841,P51665,P55036,P60900,P61289,P62191,P62195,P62333,P63208,P68371,Q06323,Q13200,Q13616,Q13885,Q14997,Q15008,Q8NCM8,Q92530,Q96J02,Q99436,Q99460,Q9BUF5,Q9BVA1,Q9UL46,Q9UNM6,Q9Y496 Sumoylation of ubiquitinylation proteins 27 39 5.457672849915683 2.911658097257315e-07 3.0640804674493086e-06 O15504,O75694,P12270,P35658,P37198,P49790,P49792,P52948,P57740,P78406,Q12769,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7 Signaling by alk in cancer 33 52 4.217374290745451 3.3509837492823853e-07 3.502895012583187e-06 O43815,O94979,P06748,P06753,P10644,P12270,P18206,P19174,P26038,P26641,P27361,P28482,P31939,P33176,P35579,P40763,P49589,P49792,P51608,P62753,P62993,P63208,P67936,Q00610,Q07866,Q13616,Q14203,Q86WB0,Q8IWJ2,Q92734,Q9HC35,Q9NR09,Q9P2E9 Initiation of nuclear envelope ne reformation 17 20 13.716190476190476 3.7210983089912974e-07 3.864027912912817e-06 O75531,P02545,P06493,P14635,P20700,P30153,P42166,P42167,P50402,P63151,Q14739,Q14974,Q86XL3,Q8IXJ6,Q8NC56,Q99986,Q9Y2U8 Pcna dependent long patch base excision repair 19 24 9.201547258661284 6.159934168181507e-07 6.3544584050714494e-06 P12004,P15927,P18858,P27694,P27695,P28340,P35244,P35249,P35250,P35251,P39748,P40937,P40938,P41440,P49005,Q07864,Q9NR33,Q9NRF9,Q9Y2S7 Interferon signaling 64 128 2.4385245901639343 6.25902960526667e-07 6.4144826281425745e-06 O00505,O15344,O15504,O43432,O60573,O75369,O75694,P01889,P04439,P06730,P10321,P12270,P18031,P19174,P19474,P19525,P21333,P27361,P29372,P35658,P37198,P38919,P42224,P49790,P49792,P52292,P52294,P52948,P55265,P57740,P60842,P61088,P61221,P78344,P78406,Q04637,Q06124,Q12769,Q12899,Q13325,Q13526,Q13555,Q14240,Q14258,Q14974,Q5SRE5,Q6L8Q7,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7,Q9Y3Z3,Q9Y4X5 Uch proteinases 44 79 3.057142857142857 8.410725619955021e-07 8.534027087391658e-06 O00231,O00232,O00487,O14818,O15294,O43242,O75832,O96019,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51610,P51665,P55036,P60900,P61289,P62191,P62195,P62333,Q06323,Q13200,Q14997,Q15008,Q16186,Q8NB78,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6,Q9Y265,Q9Y5K5 Respiratory electron transport 53 101 2.6884711353067936 8.436059939704765e-07 8.534027087391658e-06 O00217,O00483,O14949,O43674,O43676,O43678,O43819,O75251,O75306,O75380,O75489,O75880,O95168,O95182,O95299,O96000,P00403,P03886,P08574,P09669,P10606,P13073,P13804,P14927,P15954,P19404,P20674,P21912,P22695,P28331,P31040,P31930,P38117,P42704,P49821,P51970,Q12931,Q16134,Q16718,Q16795,Q7L592,Q86Y39,Q8N183,Q8TB37,Q9BQ95,Q9BU61,Q9H845,Q9NPL8,Q9NX14,Q9P032,Q9P0J0,Q9UDW1,Q9Y6M9 Mitotic prometaphase 90 198 2.037675166551803 9.299114415655671e-07 9.346802181889802e-06 O00139,O14980,O43237,O43264,O43684,O43805,O60216,O60566,O75122,O75935,O94927,O95347,O95684,P04350,P06493,P07437,P07900,P14635,P17612,P19784,P30153,P30154,P41208,P43034,P46060,P49792,P50748,P52948,P53350,P57740,P61163,P61981,P62258,P63167,P67870,P68371,Q12769,Q13257,Q13409,Q13561,Q13885,Q14008,Q14203,Q14204,Q14683,Q14738,Q14980,Q15003,Q15005,Q15021,Q15154,Q15691,Q29RF7,Q2NKX8,Q53HL2,Q68CZ6,Q7Z460,Q7Z4H7,Q7Z5K2,Q8N3U4,Q8NBT2,Q8NFH3,Q8NFH4,Q8TD19,Q8WUM0,Q8WVM7,Q8WYP5,Q92674,Q96CS2,Q96CW5,Q96EA4,Q96EE3,Q96FJ2,Q99661,Q9BPX3,Q9BSJ2,Q9BUF5,Q9BVA1,Q9BW27,Q9BZD4,Q9H6D7,Q9HBM1,Q9HC35,Q9NQS7,Q9NTI5,Q9NTJ3,Q9P258,Q9UQE7,Q9Y266,Q9Y6G9 Sumoylation of rna binding proteins 30 47 4.281884259443142 9.596454889044655e-07 9.58423010574651e-06 O15504,O75694,P07910,P12270,P35658,P37198,P49790,P49792,P52948,P57740,P61978,P78406,Q12769,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7,Q9Y2X3 Copi independent golgi to er retrograde traffic 29 45 4.39697941275734 1.0866338369135947e-06 1.0783809216965295e-05 O43237,O75935,P04350,P43034,P47755,P47756,P52907,P61163,P63167,P68371,P68402,Q10471,Q10472,Q13409,Q13561,Q13885,Q14203,Q14204,Q15042,Q15102,Q8TD16,Q96FJ2,Q9BUF5,Q9BVA1,Q9H2M9,Q9NP72,Q9NZ32,Q9UJW0,Q9Y6G9 Interleukin 1 signaling 45 82 2.95779491741487 1.1082074174815767e-06 1.0928737299440959e-05 O00231,O00232,O00487,O14818,O15111,O43242,O75832,P05067,P09429,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61088,P61289,P62191,P62195,P62333,P63208,Q02750,Q06323,Q13200,Q13616,Q14997,Q15008,Q15750,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Diseases of signal transduction by growth factor receptors and second messengers 138 333 1.737987170502938 1.143342376792344e-06 1.120475529256497e-05 O00203,O00231,O00232,O00487,O14818,O15111,O15164,O15514,O43242,O43252,O43815,O75832,O94905,O94979,O95429,O95684,P02545,P06748,P06753,P07900,P10644,P12270,P17980,P18206,P19174,P19387,P19388,P20618,P22681,P24928,P25786,P25787,P25788,P25789,P26038,P26641,P27361,P28066,P28070,P28072,P28074,P28482,P30086,P30153,P30154,P30876,P31751,P31939,P31946,P33176,P35222,P35232,P35269,P35579,P35998,P40763,P41240,P42224,P42345,P43686,P46940,P48556,P48729,P49589,P49720,P49721,P49792,P49840,P49841,P51114,P51608,P51665,P55036,P55072,P56545,P60900,P61289,P62140,P62191,P62195,P62333,P62487,P62753,P62875,P62942,P62993,P63000,P63208,P67936,P84095,Q00610,Q01082,Q02750,Q06124,Q06323,Q07866,Q09161,Q13200,Q13363,Q13547,Q13555,Q13573,Q13616,Q14203,Q14738,Q14789,Q14997,Q15008,Q16543,Q16630,Q53H12,Q6UN15,Q6WCQ1,Q7KZF4,Q7Z2W4,Q86WB0,Q8IWJ2,Q92530,Q92542,Q92614,Q92734,Q92769,Q96B36,Q96PU8,Q99436,Q99460,Q99956,Q9HC35,Q9NR09,Q9NRY5,Q9NWH9,Q9P2E9,Q9UBV2,Q9UBW7,Q9UL46,Q9UNM6,Q9UQ13,Q9Y490 Slc transporter disorders 33 54 3.8146574614976103 1.1811792868925703e-06 1.150365914191025e-05 O15504,O75694,P08195,P11166,P12270,P19367,P35613,P35658,P37198,P49790,P49792,P52948,P53985,P57740,P78406,Q12769,Q5SRE5,Q6P1M0,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7 Resolution of sister chromatid cohesion 60 120 2.43656207366985 1.3923940973182865e-06 1.347699965799428e-05 O00139,O14980,O43237,O43264,O43684,O60216,O60566,O75122,P04350,P06493,P14635,P30153,P30154,P43034,P46060,P49792,P50748,P52948,P53350,P57740,P63167,P68371,Q12769,Q13257,Q13409,Q13885,Q14008,Q14204,Q14683,Q14738,Q15005,Q15691,Q29RF7,Q2NKX8,Q53HL2,Q7Z460,Q7Z5K2,Q8N3U4,Q8NBT2,Q8NFH3,Q8NFH4,Q8WUM0,Q8WVM7,Q8WYP5,Q92674,Q96EA4,Q96EE3,Q96FJ2,Q99661,Q9BUF5,Q9BVA1,Q9BW27,Q9BZD4,Q9HBM1,Q9NQS7,Q9NTI5,Q9P258,Q9UQE7,Q9Y266,Q9Y6G9 Tcr signaling 46 85 2.8686441415565653 1.4312454686222305e-06 1.3684103017071082e-05 O00231,O00232,O00487,O14818,O15111,O43242,O75832,P17980,P19174,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P41240,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61088,P61289,P62191,P62195,P62333,P63208,Q06323,Q13177,Q13200,Q13616,Q14997,Q15008,Q16512,Q8N8S7,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Clec7a dectin 1 signaling 46 85 2.8686441415565653 1.4312454686222305e-06 1.3684103017071082e-05 O00231,O00232,O00487,O14818,O15111,O43242,O43865,O75832,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61081,P61088,P61289,P62191,P62195,P62333,P63208,Q06323,Q08209,Q13200,Q13616,Q14997,Q15008,Q15750,Q8TBC4,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Translocation of slc2a4 glut4 to the plasma membrane 38 66 3.296837218299642 1.5474610178054861e-06 1.470556894496365e-05 O00159,O00161,O00186,O00471,O60343,O60645,P04350,P11233,P20338,P27348,P31751,P31946,P35579,P51153,P54619,P61006,P61026,P61106,P61981,P62258,P63000,P63104,P68371,Q04917,Q12846,Q13885,Q86YS7,Q8IYI6,Q8TAG9,Q96A65,Q96KP1,Q9BUF5,Q9BVA1,Q9BZE9,Q9UIQ6,Q9UPT5,Q9Y3B8,Q9Y496 Gluconeogenesis 19 25 7.66689090705236 1.8576764020084133e-06 1.754720842379031e-05 O75746,P00505,P00558,P04075,P04406,P06733,P06744,P09972,P11498,P17174,P18669,P40925,P40926,P53007,P60174,Q02978,Q16822,Q9UBX3,Q9UJS0 Polymerase switching 14 16 16.928811282740092 2.1808621268983303e-06 2.047659769447055e-05 P09884,P12004,P28340,P35249,P35250,P35251,P40937,P40938,P41440,P49005,P49642,P49643,Q14181,Q9Y2S7 Hcmv early events 43 79 2.9032817150823256 2.5583240473278973e-06 2.387769110839371e-05 O15504,O43237,O75694,P04350,P05556,P12270,P35658,P37198,P49790,P49792,P52948,P57740,P62805,P63167,P68371,P78406,P83916,Q12769,Q13263,Q13409,Q13885,Q14204,Q15022,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92621,Q96EE3,Q96FJ2,Q99567,Q9BTX1,Q9BUF5,Q9BVA1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7,Q9Y6G9 Trna processing 55 109 2.479539464558191 2.640264668791787e-06 2.4496656808671728e-05 O15091,O15504,O43592,O75648,O75694,P07814,P12270,P33240,P35658,P37198,P49790,P49792,P52948,P57740,P62826,P78346,P78406,Q08J23,Q10570,Q12769,Q52LJ0,Q5KU26,Q5SRE5,Q5VV42,Q7L0Y3,Q7Z3B4,Q7Z4G4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92499,Q92621,Q969Y2,Q96EE3,Q96PZ0,Q99567,Q99575,Q99714,Q9BQ52,Q9BTX1,Q9BVC5,Q9BVL2,Q9BW27,Q9H974,Q9NPF4,Q9NRG9,Q9NX74,Q9UJA5,Q9UKX7,Q9Y224,Q9Y3I0,Q9Y606 Metabolism of nucleotides 44 82 2.814611154752553 3.2667890518443834e-06 2.9955118323344988e-05 O15067,O43598,P00390,P00491,P00492,P00568,P00813,P04183,P04818,P07741,P11172,P12268,P15531,P17812,P20839,P22102,P22234,P22392,P23919,P23921,P27144,P27708,P30085,P30520,P30566,P31350,P31939,P33316,P36639,P49902,P49915,P54819,P55263,Q05682,Q06203,Q16881,Q9BW91,Q9BY32,Q9BZX2,Q9H0P0,Q9H773,Q9NRF8,Q9UKK9,Q9Y3Z3 Transcription coupled nucleotide excision repair tc ner 44 82 2.814611154752553 3.2667890518443834e-06 2.9955118323344988e-05 O15514,O60306,P12004,P15927,P18074,P18858,P18887,P19387,P19388,P19447,P23193,P24928,P27694,P28340,P30876,P35244,P35249,P35250,P35251,P40937,P40938,P41440,P49005,P49916,P61201,P62487,P62875,Q07864,Q13098,Q13620,Q16531,Q7L5N1,Q92905,Q93009,Q99627,Q9BT78,Q9HCS7,Q9NR33,Q9NRF9,Q9UBW8,Q9UMS4,Q9UNP9,Q9UNS2,Q9Y2S7 Unfolded protein response upr 41 75 2.9299140869495885 3.763189930693566e-06 3.430628960074135e-05 O14773,O76024,O94979,O95070,O95453,P02545,P05198,P08240,P08243,P14625,P20042,P27797,P35611,P43307,P49748,P49840,P51858,P61421,Q06210,Q06265,Q13217,Q13868,Q14203,Q15024,Q15084,Q5RKV6,Q8N6T3,Q92945,Q969H8,Q96B26,Q9HCU5,Q9NPD3,Q9NQT4,Q9NQT5,Q9NWM8,Q9UBS4,Q9Y2L1,Q9Y3B2,Q9Y490,Q9Y4L1,Q9Y5M8 Transcriptional regulation by runx2 51 100 2.5321458062993982 4.058164136505078e-06 3.678151078635816e-05 O00231,O00232,O00487,O14818,O43242,O75832,P06493,P11802,P14635,P17931,P17980,P20618,P25786,P25787,P25788,P25789,P27361,P28066,P28070,P28072,P28074,P28482,P31751,P35998,P42224,P43686,P48556,P49720,P49721,P49841,P51665,P55036,P60900,P61289,P62191,P62195,P62333,P63208,Q06323,Q13200,Q13309,Q13616,Q14997,Q15008,Q92530,Q96PK6,Q99436,Q99460,Q9UL46,Q9UNE7,Q9UNM6 Rhoh gtpase cycle 22 32 5.328888888888889 4.517248699676479e-06 4.0707160695935164e-05 O75116,O75323,P02786,P11182,P14923,P27105,P41240,P51149,P52565,P55072,Q13177,Q13464,Q15758,Q16512,Q16643,Q6IAA8,Q8TAA9,Q8WWQ0,Q99707,Q9BXB4,Q9UNZ2,Q9Y6M7 Cohesin loading onto chromatin 10 10 inf 4.684855679779537e-06 4.197630689082465e-05 O60216,Q14683,Q29RF7,Q6KC79,Q7Z5K2,Q8N3U4,Q8WVM7,Q9NTI5,Q9UQE7,Q9Y6X3 Extension of telomeres 31 52 3.581045657033499 5.220897739404881e-06 4.6250664719699734e-05 O00743,O60832,P09884,P12004,P15927,P18858,P24941,P27694,P28340,P35244,P35249,P35250,P35251,P39748,P40937,P40938,P41440,P49005,P49642,P49643,P51530,P54132,Q14181,Q5H9R7,Q8WVB6,Q9NX24,Q9NY12,Q9NYB0,Q9Y230,Q9Y265,Q9Y2S7 Mrna splicing minor pathway 31 52 3.581045657033499 5.220897739404881e-06 4.6250664719699734e-05 O15514,O75533,O75643,O94906,P19387,P19388,P24928,P30876,P35269,P55769,P62304,P62314,P62316,P62318,P62487,P62875,P67809,Q07955,Q09161,Q13247,Q13435,Q15029,Q15393,Q15427,Q16629,Q6P2Q9,Q86XP3,Q96DI7,Q9BUQ8,Q9Y333,Q9Y3B4 Sumoylation of dna damage response and repair proteins 41 76 2.8458052960255604 5.870725778091185e-06 5.1715157415994264e-05 O15504,O60216,O75694,P09874,P12270,P27694,P35658,P37198,P38398,P41208,P49790,P49792,P52948,P54132,P57740,P78406,Q12769,Q14676,Q14683,Q5SRE5,Q7Z3B4,Q8IY18,Q8N1F7,Q8N3U4,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q8WVM7,Q92621,Q96EE3,Q96MG7,Q96SB8,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7,Q9UQE7 Developmental biology 246 665 1.450675923495577 6.77548994686373e-06 5.93517778585605e-05 A0MZ66,O00231,O00232,O00330,O00487,O00560,O14818,O15020,O15143,O15144,O15145,O15514,O43242,O60244,O60271,O75116,O75122,O75448,O75832,O94813,O94973,O95239,O95782,P04350,P05387,P05388,P05556,P07384,P07737,P07900,P08238,P08708,P08865,P09496,P09497,P11142,P11802,P11940,P13861,P14923,P15170,P15311,P15880,P15924,P16104,P17612,P17980,P18077,P18124,P18621,P19022,P19174,P19387,P19388,P19784,P20618,P23396,P23528,P24928,P24941,P25398,P25786,P25787,P25788,P25789,P26038,P26373,P27361,P27635,P28066,P28070,P28072,P28074,P28482,P30050,P30876,P31751,P32969,P35080,P35221,P35222,P35241,P35268,P35579,P35580,P35659,P35998,P36578,P38919,P39019,P39023,P40429,P40763,P42766,P43686,P46776,P46777,P46778,P46779,P46781,P46782,P46783,P46939,P47914,P48556,P49207,P49720,P49721,P49841,P50570,P50914,P51532,P51665,P51812,P53680,P55036,P59998,P60660,P60866,P60900,P60953,P61158,P61160,P61247,P61254,P61289,P61313,P61353,P61513,P61586,P61927,P61964,P62081,P62191,P62195,P62241,P62244,P62249,P62263,P62266,P62269,P62277,P62280,P62333,P62424,P62487,P62495,P62701,P62750,P62753,P62805,P62829,P62841,P62847,P62851,P62857,P62861,P62875,P62888,P62899,P62906,P62910,P62913,P62917,P62993,P63000,P63010,P63173,P63220,P67870,P68371,P83731,P83881,P84098,Q00535,Q00610,Q01082,Q01518,Q02543,Q02750,Q02878,Q03164,Q04637,Q06124,Q06323,Q07020,Q09161,Q12955,Q13177,Q13200,Q13464,Q13573,Q13617,Q13813,Q13885,Q14126,Q14195,Q14574,Q14966,Q14997,Q15008,Q15022,Q15287,Q15291,Q15334,Q15369,Q15370,Q15375,Q15418,Q15648,Q16512,Q16539,Q16555,Q16850,Q7Z406,Q7Z460,Q86X55,Q8N8S7,Q92530,Q92542,Q92600,Q92747,Q92769,Q96CW1,Q96P70,Q96S59,Q99436,Q99460,Q9BPU6,Q9BUF5,Q9BVA1,Q9BZI7,Q9HAU5,Q9NPJ6,Q9NR12,Q9NR77,Q9NWH9,Q9UBL3,Q9UL46,Q9ULK4,Q9UNM6,Q9Y2W1,Q9Y2X0,Q9Y3U8,Q9Y490,Q9Y5S9 Telomere maintenance 40 74 2.857484457197513 7.135199690905889e-06 6.215551730744686e-05 O00743,O15514,O60832,P09884,P12004,P15927,P16104,P18858,P19387,P19388,P24928,P24941,P27694,P28340,P30876,P35244,P35249,P35250,P35251,P39748,P40937,P40938,P41440,P49005,P49642,P49643,P51530,P54132,P62487,P62805,P62875,Q14181,Q5H9R7,Q8WVB6,Q9NX24,Q9NY12,Q9NYB0,Q9Y230,Q9Y265,Q9Y2S7 Hcmv late events 35 62 3.1462693671012913 7.336716960121349e-06 6.355785742248771e-05 O15504,O75694,P12270,P35658,P37198,P49790,P49792,P52948,P57740,P61978,P62805,P78406,Q12769,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q8WUX9,Q92621,Q96EE3,Q99567,Q99816,Q9BRG1,Q9BTX1,Q9BVL2,Q9BW27,Q9H9H4,Q9NRG9,Q9UKX7,Q9UN37,Q9UQN3 Cyclin a cdk2 associated events at s phase entry 42 79 2.75780119102153 7.407596807876741e-06 6.381929557555346e-05 O00231,O00232,O00487,O14818,O43242,O75832,P11802,P17980,P20618,P24941,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P31751,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,P63208,Q06323,Q13200,Q13309,Q13616,Q15008,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Processive synthesis on the lagging strand 14 17 11.284307141258115 8.995624461165932e-06 7.665836497341404e-05 P09884,P12004,P15927,P18858,P27694,P28340,P35244,P39748,P49005,P49642,P49643,P51530,Q14181,Q9Y2S7 Ksrp khsrp binds and destabilizes mrna 14 17 11.284307141258115 8.995624461165932e-06 7.665836497341404e-05 O95453,P63104,Q06265,Q13868,Q15024,Q16539,Q5RKV6,Q92945,Q96B26,Q9NPD3,Q9NQT4,Q9NQT5,Q9Y2L1,Q9Y3B2 Sumoylation 71 155 2.0602859425180546 9.199641219017778e-06 7.79731753049723e-05 O14965,O15504,O60216,O75694,P04637,P06748,P07910,P09874,P11387,P11388,P12004,P12270,P17844,P26358,P27694,P35658,P37198,P38398,P41208,P45973,P46060,P49790,P49792,P52948,P54132,P57740,P61978,P62805,P78406,Q02880,Q12769,Q12888,Q13263,Q13330,Q13363,Q13547,Q14676,Q14683,Q15022,Q15424,Q53HL2,Q5SRE5,Q7Z3B4,Q8IY18,Q8N1F7,Q8N3U4,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q8WVM7,Q92621,Q92769,Q92841,Q96EE3,Q96MG7,Q96SB8,Q96ST3,Q99497,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9NQS7,Q9NRG9,Q9UBE0,Q9UBT2,Q9UKX7,Q9UQE7,Q9Y2X3 Activation of the pre replicative complex 22 33 4.843771043771044 9.796100031117377e-06 8.258217660640885e-05 O43913,O75419,P09884,P15927,P24941,P25205,P27694,P33991,P33992,P33993,P35244,P49642,P49643,P49736,Q07864,Q14181,Q14566,Q7L590,Q9NR33,Q9NRF9,Q9UBD5,Q9Y619 Mitochondrial calcium ion transport 16 21 7.740860215053764 1.2025055077223563e-05 0.0001008304083480564 O75439,O95202,P21796,P35232,P45880,Q10713,Q8IYU8,Q8NE86,Q8WWC4,Q92667,Q96TA2,Q99623,Q9BPX6,Q9UJZ1,Q9Y277,Q9Y4W6 Cristae formation 19 27 5.748570467541204 1.221398829119576e-05 0.00010186985979039869 O75431,O75947,O75964,P06576,P24539,P25705,P36542,P38646,P48047,P56134,P56385,Q13505,Q16891,Q5XKP0,Q6UXV4,Q9BUR5,Q9NVH1,Q9NX63,Q9Y512 Rho gtpase cycle 152 387 1.5871860952951753 1.2630859491283835e-05 0.000104789352816577 A4D1P6,O00161,O14964,O15173,O15498,O43396,O60610,O75116,O75323,O75489,O75955,O75976,O95202,O95292,P02786,P05556,P06753,P07900,P07910,P08238,P08670,P11182,P12277,P12814,P14923,P15924,P20700,P27105,P28288,P30519,P31948,P34897,P38159,P40227,P41240,P41440,P42166,P42167,P46940,P47756,P49257,P50402,P51149,P51572,P51648,P52565,P55072,P60953,P61201,P61586,P61604,P62993,P62995,P63000,P63167,P67936,P78371,P80723,P84095,Q00610,Q01082,Q01968,Q02952,Q03001,Q07021,Q07065,Q07960,Q08378,Q12792,Q13098,Q13112,Q13177,Q13190,Q13464,Q13492,Q13505,Q13576,Q13618,Q13813,Q13838,Q14126,Q14160,Q14254,Q14344,Q14739,Q15058,Q15758,Q15904,Q16512,Q16513,Q16543,Q16643,Q16718,Q5JTV8,Q5T2T1,Q5T8D3,Q5VTR2,Q68EM7,Q6IAA8,Q7L576,Q7Z6E9,Q86UP2,Q86XL3,Q8IYB3,Q8N684,Q8NBN3,Q8NHP6,Q8TAA9,Q8WVM8,Q8WWQ0,Q92783,Q92888,Q92974,Q93008,Q96AC1,Q96CS3,Q96DH6,Q96F07,Q96HY6,Q96JJ3,Q96KM6,Q96N67,Q96T58,Q99707,Q99832,Q9BSJ8,Q9BT78,Q9BTT6,Q9BX68,Q9BXB4,Q9H0H5,Q9H2G2,Q9HD26,Q9NNW5,Q9NQW6,Q9NRG9,Q9NSV4,Q9NYL9,Q9P0I2,Q9P2R3,Q9UDY2,Q9UEY8,Q9UH62,Q9UM54,Q9UNZ2,Q9UQB8,Q9Y266,Q9Y2A7,Q9Y2I1,Q9Y2U8,Q9Y512,Q9Y6M7 Signaling by interleukins 104 248 1.7655432440751 1.2855292262731196e-05 0.0001055345459055629 O00170,O00231,O00232,O00487,O14818,O14979,O15111,O43242,O75832,P04083,P04179,P04637,P05067,P05388,P05556,P07237,P07355,P07900,P08670,P09429,P09601,P09661,P11142,P11233,P14174,P14625,P17612,P17980,P17987,P20618,P20700,P22626,P22681,P23528,P25786,P25787,P25788,P25789,P26038,P27361,P27824,P28066,P28070,P28072,P28074,P28482,P30153,P30154,P35998,P37837,P38646,P40222,P40763,P42224,P43686,P46108,P46109,P48556,P49720,P49721,P51452,P51532,P51665,P51809,P51812,P52597,P52907,P55036,P60900,P60953,P61088,P61289,P62191,P62195,P62333,P62993,P63104,P63208,P78417,Q02750,Q06124,Q06323,Q07820,Q12846,Q13126,Q13177,Q13200,Q13616,Q14738,Q14997,Q15008,Q15418,Q15750,Q16539,Q16658,Q53EL6,Q8IV63,Q92530,Q99436,Q99439,Q99460,Q9H3K6,Q9UL46,Q9UNM6 Potential therapeutics for sars 37 68 2.897232683805469 1.2794618546924023e-05 0.0001055345459055629 O00422,O60341,O60885,O75116,O94776,O94973,O95782,O95983,P05023,P05026,P05556,P07437,P07900,P08238,P12268,P20839,P21964,P49356,P53680,P54709,P62942,P63010,Q02790,Q13330,Q13464,Q13546,Q13547,Q13618,Q14839,Q15185,Q86YP4,Q8WXI9,Q92769,Q96CW1,Q99720,Q9NZI8,Q9UKL0 Mitotic spindle checkpoint 54 111 2.304575257067106 1.2945045390111307e-05 0.00010571787068590901 O00139,O14980,O43237,O43264,O43684,O60566,O75122,P30153,P30154,P30260,P43034,P46060,P49792,P50748,P52948,P53350,P57740,P63167,Q12769,Q13257,Q13409,Q14008,Q14204,Q14738,Q15005,Q15691,Q16763,Q2NKX8,Q53HL2,Q7Z460,Q8NBT2,Q8NFH3,Q8NFH4,Q8WUM0,Q8WYP5,Q92674,Q96DE5,Q96EA4,Q96EE3,Q96FJ2,Q99661,Q9BW27,Q9BZD4,Q9H1A4,Q9HBM1,Q9NQS7,Q9P258,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6,Q9Y266,Q9Y6G9 Ub specific processing proteases 69 151 2.0502574201246633 1.3534460182862492e-05 0.0001099587231436704 O00231,O00232,O00487,O14818,O14964,O43242,O60493,O75832,O94826,O94966,P04637,P14735,P17980,P20618,P21796,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P45880,P45974,P48556,P49720,P49721,P51665,P51784,P54578,P55036,P60900,P61289,P62191,P62195,P62333,Q06323,Q13200,Q13309,Q13546,Q14318,Q14694,Q14997,Q15008,Q15388,Q15750,Q16186,Q86UV5,Q8IXI2,Q92530,Q92890,Q93008,Q93009,Q96FW1,Q96K76,Q96RU2,Q99436,Q99460,Q9NZL9,Q9UL46,Q9UNM6,Q9UPU5,Q9Y265,Q9Y277,Q9Y3E5,Q9Y4A5 Apoptotic execution phase 28 47 3.5723417856381845 1.5173153521675294e-05 0.0001226366222782828 O00273,O00429,P02545,P07305,P08670,P09429,P10412,P15924,P16402,P16403,P20700,P26583,P35222,P35611,P51572,P52294,Q07157,Q13177,Q13464,Q13813,Q14126,Q14974,Q15149,Q16625,Q9P289,Q9UDY2,Q9UJU6,Q9UKV3 Advanced glycosylation endproduct receptor signaling 9 9 inf 1.5998868525406347e-05 0.00012864731204019052 P05067,P09429,P14314,P17931,P27361,P28482,P39656,P47755,P52907 Fatty acid metabolism 56 117 2.2334837182293295 1.656327326720304e-05 0.0001325061861376243 O00154,O00763,O00767,O14734,O15254,O43772,O43808,O60488,O75521,O95573,O95864,P05165,P05166,P09110,P09960,P11310,P16152,P22033,P22307,P23786,P30084,P33121,P34913,P40939,P42126,P42765,P49327,P49748,P50416,P50897,P51648,P51659,P53007,P53396,P55084,Q13085,Q14914,Q15067,Q15165,Q15185,Q16836,Q4G176,Q53GQ0,Q5T8D3,Q709F0,Q8IVS2,Q8N8N7,Q9BY49,Q9H7Z7,Q9NPJ3,Q9NZ01,Q9P035,Q9UJ83,Q9UMR5,Q9Y305,Q9Y6X9 Mitochondrial protein import 33 59 3.0789247926794396 1.735512707881176e-05 0.00013813623989632914 O14925,O43615,O60830,O75390,O75431,O75439,O75746,O94826,O96008,P06576,P08574,P10809,P12235,P12236,P21796,P25705,P38646,Q10713,Q13505,Q15388,Q3ZCQ8,Q5JRX3,Q8N4H5,Q99595,Q99798,Q9HAV7,Q9NS69,Q9NX63,Q9UJS0,Q9Y276,Q9Y512,Q9Y5J9,Q9Y5L4 Pten regulation 60 128 2.147500200625953 1.8787551126424803e-05 0.00014803457369966878 O00231,O00232,O00487,O14818,O43242,O60341,O75832,O94776,O95983,P04637,P17980,P19784,P20618,P25786,P25787,P25788,P25789,P27361,P28066,P28070,P28072,P28074,P28482,P31751,P35998,P42345,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,P67870,Q06323,Q13200,Q13330,Q13547,Q14839,Q14997,Q15008,Q15022,Q6IAA8,Q86YP4,Q8WXI9,Q92530,Q92769,Q93009,Q99436,Q99460,Q9HCE1,Q9UKL0,Q9UL46,Q9UNE7,Q9UNM6,Q9Y2Q5 Sars cov infections 60 128 2.147500200625953 1.8787551126424803e-05 0.00014803457369966878 O00422,O60341,O60885,O75116,O94776,O94973,O95782,O95983,P04843,P04844,P05023,P05026,P05556,P07437,P07900,P08238,P12268,P14314,P17844,P20839,P21964,P27824,P39656,P46977,P48729,P49356,P49840,P49841,P53680,P54709,P55072,P61803,P62942,P63010,P78362,Q02790,Q10472,Q13330,Q13464,Q13546,Q13547,Q13618,Q13724,Q14697,Q14839,Q15185,Q16706,Q86YP4,Q8WUX9,Q8WXI9,Q92769,Q96CW1,Q96SB4,Q99570,Q99720,Q99873,Q9H0U3,Q9NZI8,Q9UKL0,Q9UQN3 Trans golgi network vesicle budding 37 69 2.8063028764805416 1.9844307123214944e-05 0.00015557936784600516 O00161,O00203,O00443,O14964,O14976,O43747,O60749,O75976,P02786,P05067,P09496,P09497,P11142,P11717,P15586,P20645,P50570,P51148,P51809,P54920,P55327,Q00610,Q01968,Q10567,Q12846,Q13492,Q14671,Q14677,Q14789,Q8NBS9,Q92538,Q92572,Q99523,Q9BXS5,Q9H3P7,Q9Y5X1,Q9Y5X3 Hcmv infection 50 102 2.337499346336872 2.0643547786486465e-05 0.00016104021357816307 O15504,O43237,O75694,P04350,P05556,P12270,P35658,P37198,P49790,P49792,P52948,P57740,P61978,P62805,P63167,P68371,P78406,P83916,Q12769,Q13263,Q13409,Q13885,Q14204,Q15022,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q8WUX9,Q92621,Q96EE3,Q96FJ2,Q99567,Q99816,Q9BRG1,Q9BTX1,Q9BUF5,Q9BVA1,Q9BVL2,Q9BW27,Q9H9H4,Q9NRG9,Q9UKX7,Q9UN37,Q9UQN3,Q9Y6G9 C type lectin receptors clrs 49 100 2.3351988433837687 2.522596323351822e-05 0.00019536554639861285 O00231,O00232,O00487,O14818,O15111,O43242,O43865,O75832,P17612,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61081,P61088,P61289,P62191,P62195,P62333,P63208,Q06323,Q08209,Q13177,Q13200,Q13616,Q14997,Q15008,Q15750,Q16512,Q8TBC4,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Base excision repair 31 55 3.132106270404143 2.529286091767756e-05 0.00019536554639861285 P09874,P12004,P13051,P15927,P16104,P18858,P18887,P27694,P27695,P28340,P29372,P35244,P35249,P35250,P35251,P39748,P40937,P40938,P41440,P49005,P49916,P62805,Q07864,Q86W56,Q96T60,Q9NR33,Q9NRF9,Q9NX46,Q9NYB0,Q9UGN5,Q9Y2S7 Nucleotide biosynthesis 13 16 10.474767819178695 2.5468636737079262e-05 0.00019575893335166804 O15067,P11172,P12268,P20839,P22102,P22234,P27708,P30520,P30566,P31939,P49915,Q05682,Q06203 Interleukin 1 family signaling 47 95 2.3792586304470853 2.6777003782820023e-05 0.0002048114240559112 O00231,O00232,O00487,O14818,O15111,O43242,O75832,P05067,P09429,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P40763,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61088,P61289,P62191,P62195,P62333,P63208,Q02750,Q06124,Q06323,Q13200,Q13616,Q14997,Q15008,Q15750,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Transport of small molecules 147 377 1.5667120042790557 2.7144223989026596e-05 0.00020661234570288207 O00231,O00232,O00487,O14818,O15118,O43242,O75027,O75439,O75477,O75832,O76003,O94905,O94973,O95202,O95782,P02786,P05023,P05026,P05141,P05198,P07237,P08183,P08195,P09496,P09601,P10644,P11166,P12235,P12236,P13861,P16615,P17612,P17980,P20020,P20042,P20618,P21281,P21283,P21399,P21796,P25786,P25787,P25788,P25789,P27105,P28066,P28070,P28072,P28074,P28288,P30519,P30626,P30825,P35232,P35610,P35611,P35613,P35998,P36404,P36543,P38571,P38606,P40855,P43686,P45880,P48556,P49720,P49721,P51665,P51790,P51798,P53680,P53985,P54709,P55011,P55036,P55072,P60900,P61289,P61421,P61916,P62191,P62195,P62333,P63010,P63208,P98194,Q00341,Q00610,Q06323,Q10713,Q12797,Q13200,Q13546,Q13555,Q13616,Q14997,Q15008,Q15758,Q15904,Q4KMQ2,Q6P1M0,Q70HW3,Q86VP6,Q8IYU8,Q8N4V1,Q8NE71,Q8NE86,Q8TB61,Q8TDW0,Q8WTV0,Q8WWC4,Q92530,Q92667,Q93050,Q96CW1,Q96TA2,Q99436,Q99460,Q99623,Q99797,Q99808,Q9BPX6,Q9BU23,Q9BUN8,Q9C0H2,Q9H0U3,Q9H4A3,Q9H936,Q9HD20,Q9NRK6,Q9UBI6,Q9UBV2,Q9UBX3,Q9UEY8,Q9UHQ9,Q9UI12,Q9UJZ1,Q9UL46,Q9UNM6,Q9UNS2,Q9Y277,Q9Y487,Q9Y4W6,Q9Y5K8,Q9Y6B6,Q9Y6M7 Gap filling dna repair synthesis and ligation in gg ner 19 28 5.109130321037486 2.7537170275835923e-05 0.00020859073909425474 P12004,P15927,P18858,P18887,P27694,P28340,P35244,P35249,P35250,P35251,P40937,P40938,P41440,P49005,P49916,Q07864,Q9NR33,Q9NRF9,Q9Y2S7 Signaling by hedgehog 57 122 2.132999606866728 3.387643674134751e-05 0.00025294406100206143 O00231,O00232,O00487,O14818,O43242,O75832,P04350,P07237,P10644,P13861,P17612,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P48729,P49720,P49721,P49841,P51665,P55036,P55072,P60900,P61289,P62191,P62195,P62333,P63208,P68371,Q06323,Q13200,Q13616,Q13618,Q13885,Q14997,Q15008,Q6P1J9,Q8NCM8,Q92530,Q96J02,Q99436,Q99460,Q9BUF5,Q9BVA1,Q9UBV2,Q9UL46,Q9UNM6,Q9Y496 Telomere c strand lagging strand synthesis 23 37 3.978492036760814 3.3771693169011636e-05 0.00025294406100206143 P09884,P12004,P15927,P18858,P27694,P28340,P35244,P35249,P35250,P35251,P39748,P40937,P40938,P41440,P49005,P49642,P49643,P51530,P54132,Q14181,Q8WVB6,Q9NYB0,Q9Y2S7 Sumoylation of chromatin organization proteins 32 58 2.9846153846153847 3.368059363673609e-05 0.00025294406100206143 O15504,O75694,P12270,P35658,P37198,P45973,P49790,P49792,P52948,P57740,P62805,P78406,Q12769,Q13547,Q15022,Q5SRE5,Q7Z3B4,Q8N1F7,Q8NFH3,Q8NFH4,Q8NFH5,Q8TEM1,Q8WUM0,Q92621,Q92769,Q96EE3,Q99567,Q9BTX1,Q9BVL2,Q9BW27,Q9NRG9,Q9UKX7 Purine ribonucleoside monophosphate biosynthesis 10 11 24.154929577464788 3.781827440908035e-05 0.0002810381719120284 O15067,P12268,P20839,P22102,P22234,P30520,P30566,P31939,P49915,Q06203 Complex i biogenesis 31 56 3.006403242147923 4.082886389249154e-05 0.0003019795216199374 O00217,O43674,O43676,O43678,O75251,O75306,O75380,O75489,O95168,O95182,O95299,O96000,P03886,P19404,P28331,P49821,P51970,Q16718,Q16795,Q7L592,Q86Y39,Q8N183,Q8TB37,Q9BQ95,Q9BU61,Q9H845,Q9NPL8,Q9NX14,Q9P032,Q9P0J0,Q9Y6M9 Fc epsilon receptor fceri signaling 51 108 2.174323090964405 6.087509965695748e-05 0.00044813218902398745 O00231,O00232,O00487,O14818,O15111,O43242,O43865,O75832,P17980,P19174,P20618,P25786,P25787,P25788,P25789,P27361,P28066,P28070,P28072,P28074,P28482,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61088,P61289,P62191,P62195,P62333,P62993,P63000,P63208,Q06323,Q08209,Q13177,Q13200,Q13616,Q14997,Q15008,Q15750,Q16512,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Transcriptional regulation by runx1 66 149 1.9352296403659752 6.839981303002437e-05 0.0005011724618274683 O00231,O00232,O00487,O14497,O14818,O15047,O43242,O75832,O96019,P16104,P17931,P17980,P19784,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51532,P51665,P55036,P60900,P61289,P61964,P62191,P62195,P62333,P62805,P67870,Q00534,Q03164,Q06124,Q06323,Q07157,Q12824,Q13200,Q13547,Q14997,Q15008,Q15291,Q16625,Q86U86,Q8TAQ2,Q92530,Q92922,Q969G3,Q96GM5,Q96J02,Q96ST3,Q99436,Q99460,Q99873,Q9HCE1,Q9HCL2,Q9UBL3,Q9UL46,Q9UNM6 Mitochondrial trna aminoacylation 16 23 5.527649769585254 7.654731594337344e-05 0.0005582613553451607 P26640,P41250,P47897,Q15031,Q15046,Q5JPH6,Q5JTZ9,Q5ST30,Q5T160,Q6PI48,Q96GW9,Q9BW92,Q9H2U2,Q9NP81,Q9NSE4,Q9Y2Z4 Copii mediated vesicle transport 30 55 2.9084402430790006 7.848347745003816e-05 0.0005697319103780549 O00743,O15027,O15498,O60763,O75396,O94979,O95486,O95487,P46459,P49257,P49755,P53634,P53992,P54920,P62820,Q08379,Q12907,Q13190,Q15363,Q15436,Q5H9R7,Q8IUR0,Q8WVM8,Q92734,Q99747,Q9H0U4,Q9HCU5,Q9Y296,Q9Y6B6,Q9Y6Y8 Processing of intronless pre mrnas 15 21 6.044675848169298 8.043704640881161e-05 0.0005785563705000762 O43809,P33240,P51003,Q05048,Q09161,Q10570,Q12996,Q5KU26,Q6UN15,Q86U42,Q8N684,Q92797,Q9C0J8,Q9P2I0,Q9UKF6 Glutathione conjugation 15 21 6.044675848169298 8.043704640881161e-05 0.0005785563705000762 O14880,O43708,O75223,P10768,P14550,P21266,P28161,P48506,P48507,P48637,P78417,Q8WUX2,Q96KP4,Q99735,Q9Y2Q3 Signaling by the b cell receptor bcr 44 91 2.2727850111146397 9.581705027394405e-05 0.0006860325791303391 O00231,O00232,O00487,O14818,O15111,O43242,O43865,O75832,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,P62942,P62993,P63208,Q06323,Q08209,Q13200,Q13616,Q14997,Q15008,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Hiv elongation arrest and recovery 20 32 4.033198743831314 9.90658798136889e-05 0.0007060695433993828 O00267,O15514,P18615,P19387,P19388,P23193,P24928,P30876,P35269,P50750,P62487,P62875,Q08945,Q14241,Q15369,Q15370,Q8IXH7,Q8WX92,Q9H3P2,Q9Y5B9 Pyruvate metabolism 17 26 4.568253968253968 0.00014908561777231445 0.0010577658310723485 O00330,O43708,O95563,P00338,P07195,P08559,P09622,P10515,P11177,P21796,P35613,P48163,P53985,Q04760,Q15118,Q15120,Q8NCN5 Nucleotide excision repair 52 114 2.0374369102479704 0.0001588123515869576 0.0011217016544520248 O15514,O60306,O96019,P09874,P12004,P15927,P18074,P18858,P18887,P19387,P19388,P19447,P23193,P24928,P27694,P28340,P30876,P35244,P35249,P35250,P35251,P40937,P40938,P41208,P41440,P49005,P49916,P54727,P61088,P61201,P62487,P62875,Q07864,Q13098,Q13620,Q16531,Q7L5N1,Q86WJ1,Q92905,Q93009,Q99627,Q9BT78,Q9HCS7,Q9NR33,Q9NRF9,Q9UBW8,Q9UGN5,Q9UMS4,Q9UNP9,Q9UNS2,Q9Y265,Q9Y2S7 Unwinding of dna 10 12 12.075788061703555 0.0001666970258168795 0.0011721118227841572 O75419,P25205,P33991,P33992,P33993,P49736,Q14566,Q9BRT9,Q9BRX5,Q9Y248 Beta catenin independent wnt signaling 53 117 2.0118450153113305 0.0001717391877631141 0.0012021743143417988 O00231,O00232,O00487,O14818,O43242,O75832,O94973,O95782,P07737,P09496,P09497,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35222,P35998,P43686,P48556,P49720,P49721,P51665,P53680,P55036,P60900,P61289,P61586,P62191,P62195,P62333,P63000,P63010,Q00610,Q06323,Q08209,Q13200,Q14160,Q14997,Q15008,Q92530,Q96CW1,Q99436,Q99460,Q9HCE1,Q9UBI6,Q9UL46,Q9UNM6 Golgi cisternae pericentriolar stack reorganization 11 14 8.857318573185731 0.00019611505543499596 0.0013667040307647716 O60763,P06493,P14635,P27361,P28482,P53350,P61019,P62820,Q08379,Q9H0U4,Q9H8Y8 Rhod gtpase cycle 27 50 2.843126328909744 0.00022149422531447544 0.001536738695987157 O15173,O60610,O95292,P12814,P20700,P42166,P42167,P47756,P49257,P50402,P51149,Q02952,Q07960,Q14739,Q16643,Q5JTV8,Q68EM7,Q8NHP6,Q8TAA9,Q9BSJ8,Q9BX68,Q9H0H5,Q9NSV4,Q9P2R3,Q9UEY8,Q9Y2U8,Q9Y6M7 Golgi associated vesicle biogenesis 29 55 2.7020691087515254 0.0002271849375427257 0.0015692774540396208 O00203,O00443,O14976,O43747,O60749,O75976,P02786,P09496,P11142,P11717,P50570,P51148,P51809,P54920,P55327,Q00610,Q01968,Q10567,Q13492,Q14671,Q14677,Q14789,Q8NBS9,Q92572,Q99523,Q9BXS5,Q9H3P7,Q9Y5X1,Q9Y5X3 Mapk family signaling cascades 86 212 1.6624280361376025 0.00027424432666815063 0.001886031158840615 O00231,O00232,O00487,O14818,O14980,O15020,O43242,O43924,O60725,O75608,O75832,P04792,P06493,P07196,P17612,P17980,P18206,P20618,P25685,P25786,P25787,P25788,P25789,P27361,P28066,P28070,P28072,P28074,P28482,P30086,P30153,P30154,P31946,P35232,P35998,P36404,P41240,P43686,P46940,P48556,P49356,P49720,P49721,P51665,P53041,P55036,P60900,P60953,P61289,P62140,P62191,P62195,P62333,P62993,P63000,Q01082,Q02750,Q06124,Q06323,Q13177,Q13200,Q13555,Q13618,Q13813,Q14168,Q14738,Q14997,Q15008,Q15334,Q16181,Q16512,Q92530,Q96P70,Q96S59,Q99436,Q99460,Q99956,Q9HCE1,Q9NWH9,Q9NZI8,Q9UL46,Q9UNM6,Q9UQ13,Q9Y2Q5,Q9Y490,Q9Y4G8 Phase ii conjugation of compounds 28 53 2.7127125506072876 0.00027795284048464465 0.00190318800820927 O14880,O43252,O43708,O60701,O75223,O95861,P10768,P14550,P21266,P21964,P23526,P28161,P31153,P48506,P48507,P48637,P78417,Q16851,Q8TB61,Q8WUX2,Q96IU4,Q96KP4,Q99707,Q99735,Q9NUJ1,Q9NX62,Q9NZL9,Q9Y2Q3 Rhog gtpase cycle 35 71 2.356742945177169 0.00030196232682290627 0.0020585953411231175 O15173,O15498,O75489,O95202,O95292,P02786,P05556,P34897,P42166,P42167,P49257,P50402,P51149,P52565,P60953,P61604,P84095,Q07960,Q13112,Q13177,Q13190,Q13576,Q14126,Q14739,Q16718,Q5T2T1,Q6IAA8,Q7L576,Q86UP2,Q86XL3,Q8TAA9,Q96JJ3,Q9BSJ8,Q9NSV4,Q9Y2U8 Rho gtpases activate formins 58 133 1.8790365825948647 0.0003044232273844347 0.0020663879677004053 O00139,O14980,O43237,O43264,O43684,O60566,O60610,O75122,P04350,P05556,P07737,P30153,P30154,P35080,P43034,P46060,P49792,P50748,P52948,P53350,P57740,P60953,P61586,P63000,P63167,P68371,Q12769,Q13257,Q13409,Q13885,Q14008,Q14204,Q14738,Q15005,Q15691,Q2NKX8,Q53HL2,Q7Z460,Q8NBT2,Q8NFH3,Q8NFH4,Q8WUM0,Q8WYP5,Q92674,Q96EA4,Q96EE3,Q96FJ2,Q99661,Q9BUF5,Q9BVA1,Q9BW27,Q9BZD4,Q9HBM1,Q9NQS7,Q9NSV4,Q9P258,Q9Y266,Q9Y6G9 G2 m dna damage checkpoint 33 66 2.423453869550524 0.0003191306201883947 0.002156882812307771 O60934,O96017,O96028,P04637,P06493,P14635,P15927,P16104,P27348,P27694,P31946,P35244,P35249,P35250,P38398,P40937,P40938,P49959,P51530,P54132,P61088,P61981,P62258,P62805,P63104,Q04917,Q12888,Q14676,Q92878,Q9NWV8,Q9NXR7,Q9UQ84,Q9Y3B8 Cargo concentration in the er 15 23 4.532247228753779 0.00038588434892665576 0.0025968526142360355 O75396,O95486,O95487,P49257,P49755,P53634,P53992,Q12907,Q13190,Q15363,Q15436,Q5JRA6,Q96PC5,Q9HCU5,Q9Y6B6 Ire1alpha activates chaperones 24 44 2.904582210242588 0.00040215369154688165 0.002694773454467993 O14773,O76024,O94979,O95070,P02545,P08240,P35611,P43307,P49748,P49840,P51858,P61421,Q06210,Q13217,Q14203,Q15084,Q8N6T3,Q969H8,Q9HCU5,Q9NWM8,Q9UBS4,Q9Y490,Q9Y4L1,Q9Y5M8 Dual incision in tc ner 33 67 2.351847802317953 0.00045358289053378014 0.0030264594568381585 O15514,O60306,P12004,P15927,P18074,P19387,P19388,P19447,P23193,P24928,P27694,P28340,P30876,P35244,P35249,P35250,P35251,P40937,P40938,P41440,P49005,P62487,P62875,Q07864,Q13620,Q16531,Q93009,Q9HCS7,Q9NR33,Q9NRF9,Q9UMS4,Q9UNP9,Q9Y2S7 Recognition of dna damage by pcna containing replication complex 18 30 3.627437794216543 0.0004569799592295969 0.003036205830813593 P12004,P15927,P27694,P28340,P35244,P35249,P35250,P35251,P40937,P40938,P41440,P49005,Q07864,Q13620,Q16531,Q9NR33,Q9NRF9,Q9Y2S7 Condensation of prometaphase chromosomes 9 11 10.864565873281931 0.0004778551778947569 0.0031482223484831044 O95347,P06493,P14635,P19784,P67870,Q15003,Q15021,Q9BPX3,Q9NTJ3 Apoptosis induced dna fragmentation 9 11 10.864565873281931 0.0004778551778947569 0.0031482223484831044 O00273,P07305,P09429,P10412,P16402,P16403,P26583,P52294,Q14974 Hiv transcription elongation 23 42 2.9294818386484907 0.000490490152560042 0.003204535663392274 O00267,O15514,P18074,P18615,P19387,P19388,P19447,P23193,P24928,P30876,P35269,P50750,P62487,P62875,Q08945,Q09161,Q14241,Q15369,Q15370,Q8IXH7,Q8WX92,Q9H3P2,Q9Y5B9 Dual incision in gg ner 23 42 2.9294818386484907 0.000490490152560042 0.003204535663392274 P09874,P12004,P15927,P18074,P19447,P27694,P28340,P35244,P35249,P35250,P35251,P40937,P40938,P41440,P49005,Q07864,Q13620,Q16531,Q86WJ1,Q9NR33,Q9NRF9,Q9UGN5,Q9Y2S7 Nuclear events stimulated by alk signaling in cancer 12 17 5.797852348993288 0.0005188021872572591 0.003347661850285524 P06748,P27361,P28482,P33176,P40763,P51608,P62753,P63208,Q00610,Q13616,Q86WB0,Q9HC35 Mismatch repair 12 17 5.797852348993288 0.0005188021872572591 0.003347661850285524 P12004,P15927,P18858,P20585,P27694,P28340,P35244,P43246,P49005,P52701,Q9UQ84,Q9Y2S7 Tristetraprolin ttp zfp36 binds and destabilizes mrna 12 17 5.797852348993288 0.0005188021872572591 0.003347661850285524 P31946,Q06265,Q13868,Q15024,Q5RKV6,Q92973,Q96B26,Q9NPD3,Q9NQT4,Q9NQT5,Q9Y2L1,Q9Y3B2 Transcriptional regulation by runx3 40 86 2.1085189112760694 0.0005384557857992875 0.0034602404595626343 O00231,O00232,O00487,O14818,O43242,O75832,P04637,P17980,P20618,P25440,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35222,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,Q06323,Q13200,Q13573,Q15008,Q92530,Q99436,Q99460,Q9UL46,Q9UNM6 Cooperation of prefoldin and tric cct in actin and tubulin folding 17 28 3.7366233766233767 0.0005420705272000696 0.0034692513740804455 O15212,P04350,P17987,P40227,P48643,P49368,P50990,P50991,P61758,P68371,P78371,Q13885,Q99471,Q99832,Q9BUF5,Q9BVA1,Q9UHV9 Clathrin mediated endocytosis 52 119 1.8840694486749925 0.0005750111250462245 0.0036651115612702442 O00443,O14964,O14976,O15144,O15145,O94973,O95782,P02786,P09496,P09497,P11142,P11717,P20339,P20645,P22681,P42566,P50570,P51148,P51809,P53680,P59998,P61020,P61158,P61160,P61201,P62330,P62993,P63010,Q00610,Q01968,Q13098,Q13492,Q14108,Q14247,Q14C86,Q7L5N1,Q8N6T3,Q92747,Q92783,Q92905,Q96CW1,Q96D71,Q99627,Q99961,Q9BT78,Q9NVZ3,Q9UBC2,Q9UBW8,Q9UKS6,Q9UNF0,Q9UNS2,Q9Y5X1 Interconversion of nucleotide di and triphosphates 16 26 3.867741935483871 0.0006398530775459182 0.004029275604787147 P00390,P00568,P04818,P15531,P17812,P22392,P23919,P23921,P27144,P30085,P31350,P33316,P54819,Q16881,Q9H773,Q9NRF8 Nef mediated cd8 down regulation 6 6 inf 0.0006362839879295582 0.004029275604787147 O94973,O95782,P53680,P63010,Q96CW1,Q9UI12 Fgfr2 alternative splicing 16 26 3.867741935483871 0.0006398530775459182 0.004029275604787147 O15514,P09651,P19387,P19388,P24928,P26599,P30876,P31483,P31943,P35269,P52272,P52597,P62487,P62875,Q01085,Q09161 Tcf dependent signaling in response to wnt 60 142 1.777359997338036 0.0006575688585925964 0.004124271881092764 O00231,O00232,O00487,O14818,O14980,O43242,O75832,P16104,P17980,P19784,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P30153,P30154,P31751,P35222,P35998,P43686,P48556,P48729,P49720,P49721,P49841,P51532,P51665,P55036,P60900,P61289,P62191,P62195,P62333,P62805,P63104,P67870,Q06323,Q13200,Q13363,Q13547,Q13618,Q14738,Q14997,Q15008,Q15291,Q6P1J9,Q92530,Q99436,Q99460,Q9HCK8,Q9UBL3,Q9UL46,Q9UNM6,Q9Y265,Q9Y4A5 Formation of rna pol ii elongation complex 29 58 2.4215322308471143 0.0007228910993129117 0.00451590933754042 O00267,O15514,P18074,P18615,P19387,P19388,P19447,P23193,P24928,P30876,P35269,P50750,P62487,P62875,Q08945,Q09161,Q14241,Q15369,Q15370,Q6P1J9,Q6PD62,Q7KZ85,Q8IXH7,Q8N7H5,Q8WX92,Q96ST2,Q9GZS3,Q9H3P2,Q9Y5B9 Antigen presentation folding assembly and peptide loading of class i mhc 15 24 4.028104355615272 0.0007505734425255502 0.004651775327589181 O94979,O95486,O95487,P01889,P04439,P10321,P27797,P27824,P30101,P51572,P53992,Q03518,Q15436,Q9NZ08,Q9Y6B6 Cholesterol biosynthesis 15 24 4.028104355615272 0.0007505734425255502 0.004651775327589181 O75845,P14324,P37268,P48449,Q01581,Q13907,Q14534,Q14739,Q15126,Q15392,Q15738,Q15800,Q16850,Q9BWD1,Q9UBM7 Branched chain amino acid catabolism 14 22 4.228676964405642 0.0008733699584858264 0.005391512184668409 O15382,P09622,P11182,P24752,P26440,P30084,P31937,P35610,P45954,Q02252,Q6NVY1,Q96RQ3,Q99714,Q9HCC0 Recycling pathway of l1 22 41 2.801169590643275 0.000935933634726177 0.0057550742715711594 A0MZ66,O94973,O95239,O95782,P04350,P09496,P15311,P26038,P28482,P35241,P50570,P51812,P53680,P63010,P68371,Q00610,Q13885,Q15418,Q16555,Q96CW1,Q9BUF5,Q9BVA1 Processing of capped intronless pre mrna 17 29 3.4247619047619047 0.0009536960604805721 0.005841388370443505 O43809,P33240,P51003,P62304,P62318,Q05048,Q09161,Q10570,Q12996,Q5KU26,Q6UN15,Q86U42,Q8N684,Q92797,Q9C0J8,Q9P2I0,Q9UKF6 Response of mtb to phagocytosis 13 20 4.486692562221263 0.0010054635915399072 0.006110724463312304 O14964,P00558,P06733,P20339,P23246,P27361,P28482,P49840,P51149,P52294,Q14974,Q9H267,Q9UI12 Translesion synthesis by polh 13 20 4.486692562221263 0.0010054635915399072 0.006110724463312304 P12004,P15927,P27694,P35244,P35249,P35250,P35251,P40937,P40938,P41440,P55072,Q8TAT6,Q92890 Biological oxidations 42 94 1.958174706649283 0.001096059568509995 0.006635603874222673 O00170,O14880,O43169,O43252,O43488,O43708,O60701,O75223,O95861,P00387,P05091,P07099,P08238,P10768,P11766,P14550,P16435,P21266,P21964,P22570,P23526,P28161,P30837,P31153,P48506,P48507,P48637,P78417,Q15185,Q16850,Q16851,Q5VT66,Q8TB61,Q8WUX2,Q96IU4,Q96KP4,Q99707,Q99735,Q9NUJ1,Q9NX62,Q9NZL9,Q9Y2Q3 Defects in biotin btn metabolism 7 8 16.89145728643216 0.0011092501353585273 0.006638565695580805 P05165,P05166,P11498,P50747,Q13085,Q96RQ3,Q9HCC0 Recycling of eif2 gdp 7 8 16.89145728643216 0.0011092501353585273 0.006638565695580805 P05198,P20042,P49770,Q13144,Q14232,Q9NR50,Q9UI10 Dna replication initiation 7 8 16.89145728643216 0.0011092501353585273 0.006638565695580805 P09884,P49642,P49643,Q07864,Q14181,Q9NR33,Q9NRF9 Chromosome maintenance 44 100 1.9051172707889126 0.001242260944390354 0.007406331409901426 O00743,O15514,O60264,O60832,P06748,P09884,P12004,P15927,P16104,P18858,P19387,P19388,P24928,P24941,P27694,P28340,P30876,P35244,P35249,P35250,P35251,P39748,P40937,P40938,P41440,P49005,P49642,P49643,P51530,P54132,P62487,P62805,P62875,Q14181,Q5H9R7,Q8WVB6,Q92674,Q96T23,Q9NX24,Q9NY12,Q9NYB0,Q9Y230,Q9Y265,Q9Y2S7 Processing of smdt1 11 16 5.312915129151292 0.0012685134835702938 0.007534201296356897 O75439,P35232,Q10713,Q8IYU8,Q8NE86,Q8WWC4,Q96TA2,Q99623,Q9BPX6,Q9UJZ1,Q9Y4W6 Deubiquitination 86 221 1.5496265708240933 0.0012872063442966205 0.007616375652290948 O00231,O00232,O00487,O14818,O14964,O15294,O43242,O60493,O75832,O94826,O94966,O95630,O96019,P04637,P06493,P14735,P17980,P20618,P21796,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P38398,P43686,P45880,P45974,P48556,P49720,P49721,P51610,P51665,P51784,P54578,P54727,P55036,P55072,P60900,P61289,P61586,P62191,P62195,P62333,Q06323,Q13200,Q13309,Q13546,Q14258,Q14318,Q14694,Q14997,Q15008,Q15018,Q15388,Q15750,Q16186,Q7Z434,Q86UV5,Q8IXI2,Q8NB78,Q92530,Q92783,Q92890,Q93008,Q93009,Q96FW1,Q96K76,Q96RU2,Q99436,Q99460,Q9NWV8,Q9NXR7,Q9NZL9,Q9UL46,Q9UNM6,Q9UPU5,Q9Y265,Q9Y277,Q9Y3E5,Q9Y4A5,Q9Y5K5 Folding of actin by cct tric 8 10 9.654155495978552 0.0013468020463368697 0.007939043641564706 P17987,P40227,P48643,P49368,P50990,P50991,P78371,Q99832 Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 10 14 6.036217303822937 0.0013691325828546147 0.008040449025902755 O96017,P06493,P14635,P27348,P31946,P61981,P62258,P63104,Q04917,Q9Y3B8 Signaling by wnt 83 213 1.552587460665838 0.0014781471468553221 0.008648263903989348 O00231,O00232,O00487,O14818,O14980,O43242,O60493,O75436,O75832,O94973,O95782,P07737,P09496,P09497,P16104,P17980,P19784,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P30153,P30154,P31751,P35222,P35998,P43686,P48556,P48729,P49720,P49721,P49841,P51532,P51665,P53680,P55036,P56545,P60900,P61289,P61586,P62191,P62195,P62333,P62805,P63000,P63010,P63104,P63208,P67870,Q00610,Q06323,Q08209,Q13200,Q13363,Q13547,Q13616,Q13618,Q14160,Q14738,Q14997,Q15008,Q15291,Q6P1J9,Q92530,Q96CW1,Q96QK1,Q99436,Q99460,Q9HCE1,Q9HCK8,Q9UBI6,Q9UBL3,Q9UBQ0,Q9UL46,Q9UNM6,Q9Y265,Q9Y3A6,Q9Y4A5 Global genome nucleotide excision repair gg ner 39 87 1.968929901794785 0.0015059961287540048 0.008778445836008474 O96019,P09874,P12004,P15927,P18074,P18858,P18887,P19447,P27694,P28340,P35244,P35249,P35250,P35251,P40937,P40938,P41208,P41440,P49005,P49916,P54727,P61088,P61201,Q07864,Q13098,Q13620,Q16531,Q7L5N1,Q86WJ1,Q92905,Q99627,Q9BT78,Q9NR33,Q9NRF9,Q9UBW8,Q9UGN5,Q9UNS2,Q9Y265,Q9Y2S7 Abortive elongation of hiv 1 transcript in the absence of tat 14 23 3.7583016192821432 0.0016316809066586962 0.009475835783854946 O00267,O15514,P18615,P19387,P19388,P24928,P30876,P35269,P62487,P62875,Q09161,Q8IXH7,Q8WX92,Q9H3P2 Infection with mycobacterium tuberculosis 13 21 3.925310506881504 0.0019328392783177434 0.011142249957361109 O14964,P00558,P06733,P20339,P23246,P27361,P28482,P49840,P51149,P52294,Q14974,Q9H267,Q9UI12 Formation of tubulin folding intermediates by cct tric 13 21 3.925310506881504 0.0019328392783177434 0.011142249957361109 P04350,P17987,P40227,P48643,P49368,P50990,P50991,P68371,P78371,Q13885,Q99832,Q9BUF5,Q9BVA1 Polymerase switching on the c strand of the telomere 16 28 3.2222222222222223 0.0019484577658638817 0.011191142039833577 P09884,P12004,P28340,P35249,P35250,P35251,P40937,P40938,P41440,P49005,P49642,P49643,Q14181,Q8WVB6,Q9NYB0,Q9Y2S7 Tp53 regulates transcription of dna repair genes 29 61 2.1935960175497806 0.001982201683025385 0.011343402332057675 O00267,O15514,P04637,P18074,P18615,P19387,P19388,P19447,P23193,P24928,P30876,P35269,P38398,P43246,P50750,P62487,P62875,Q08945,Q14241,Q14676,Q15369,Q15370,Q8IXH7,Q8WX92,Q9BXW9,Q9H3P2,Q9NVI1,Q9NYV4,Q9Y5B9 Cargo trafficking to the periciliary membrane 22 43 2.5336860670194 0.0021192585882042485 0.012083627150197314 A6NIH7,O00471,O43924,O60645,O75695,P17987,P18085,P36405,P48643,P49368,P50990,P50991,P61006,P78371,Q10713,Q8IYI6,Q8TAG9,Q92538,Q96A65,Q96KP1,Q9NQ48,Q9UPT5 Beta oxidation of octanoyl coa to hexanoyl coa 5 5 inf 0.0021708637834203987 0.012333023233344873 P11310,P30084,P40939,P55084,Q16836 Rho gtpases activate paks 12 19 4.140172579098754 0.00227217164366022 0.01286196800454594 O14974,P21333,P35579,P35580,P60660,P60953,P62140,P63000,Q13177,Q14247,Q16512,Q7Z406 Perk regulates gene expression 15 26 3.2948056310501723 0.00236487514642669 0.013338576365457015 O95453,P05198,P08243,P20042,Q06265,Q13868,Q15024,Q5RKV6,Q92945,Q96B26,Q9NPD3,Q9NQT4,Q9NQT5,Q9Y2L1,Q9Y3B2 Selective autophagy 31 67 2.084581034935645 0.00241877893984955 0.013593711031125786 O43237,O60664,O94826,O95140,O96008,P04350,P07900,P08670,P11142,P19784,P21796,P50542,P54619,P55072,P61088,P63167,P67870,P68371,Q13409,Q13885,Q14204,Q15388,Q8IWA4,Q8N4H5,Q96FJ2,Q96HS1,Q99497,Q9BUF5,Q9BVA1,Q9NS69,Q9Y6G9 Metabolism of steroids 44 103 1.8074879838097648 0.0025250269279563564 0.014140150796555595 O00763,O00767,O14734,O75845,O95486,O95487,O95772,P04062,P14324,P15121,P22059,P22307,P22570,P30536,P37268,P38435,P48449,P49327,P51659,P53992,P62826,Q01581,Q13085,Q13907,Q14534,Q14739,Q14849,Q14974,Q15126,Q15392,Q15436,Q15648,Q15738,Q15800,Q16850,Q53GQ0,Q86X55,Q8NBQ5,Q96SU4,Q99538,Q9BWD1,Q9HCL2,Q9UBM7,Q9Y6B6 Translesion synthesis by y family dna polymerases bypasses lesions on dna template 21 41 2.5389431167956915 0.0026107321596981325 0.014568071268351145 P12004,P15927,P27694,P28340,P35244,P35249,P35250,P35251,P40937,P40938,P41440,P49005,P55072,Q07864,Q14258,Q14694,Q8TAT6,Q92890,Q9NR33,Q9NRF9,Q9Y2S7 Ldl clearance 11 17 4.426814268142682 0.0026429841934404296 0.014643813481677008 O15118,O94973,O95782,P09496,P35610,P38571,P53680,P61916,P63010,Q00610,Q96CW1 Butyrate response factor 1 brf1 binds and destabilizes mrna 11 17 4.426814268142682 0.0026429841934404296 0.014643813481677008 P31946,Q06265,Q13868,Q15024,Q5RKV6,Q96B26,Q9NPD3,Q9NQT4,Q9NQT5,Q9Y2L1,Q9Y3B2 Rmts methylate histone arginines 19 36 2.701826240082309 0.0026534900963011906 0.014650255179578403 O14497,O14744,O60678,O96019,P11802,P15880,P16104,P51532,P61964,P62805,Q12824,Q86U86,Q86X55,Q8TAQ2,Q92922,Q969G3,Q96GM5,Q99873,Q9BQA1 Aurka activation by tpx2 33 73 1.9973977695167286 0.002848405971843299 0.01567123004859752 O14965,O43805,O75330,O75935,O94927,O95684,P04350,P06493,P07437,P07900,P17612,P30153,P41208,P43034,P53350,P61163,P61981,P62258,P63167,P68371,Q13409,Q13561,Q14008,Q14203,Q14204,Q15154,Q15691,Q68CZ6,Q7Z460,Q7Z4H7,Q96CS2,Q9H6D7,Q9ULW0 Defective intrinsic pathway for apoptosis 14 24 3.3820013431833447 0.002865231356560083 0.015708681003797936 O15446,P02545,P04179,P04637,P05067,P07384,P17655,P20700,P20810,P32119,P62258,Q00535,Q07021,Q08379 Insulin receptor recycling 10 15 4.828303152246814 0.003028084890345069 0.01654368330334867 P21281,P21283,P36543,P38606,P61421,Q15904,Q93050,Q9UI12,Q9Y487,Q9Y5K8 Adaptive immune system 176 504 1.3102134146341464 0.0031440088045153972 0.017117381269028273 A0AVT1,O00139,O00161,O00231,O00232,O00487,O14818,O15020,O15111,O43237,O43242,O43747,O43865,O75396,O75832,O75935,O94822,O94874,O94973,O94979,O95235,O95239,O95376,O95486,O95487,O95782,P01889,P04350,P04439,P05556,P09429,P09496,P10321,P10619,P17612,P17980,P19174,P19474,P20618,P22314,P25786,P25787,P25788,P25789,P27797,P27824,P28066,P28070,P28072,P28074,P29144,P30101,P30153,P30154,P30260,P31751,P31946,P33176,P35998,P41240,P42345,P43686,P47755,P47756,P48556,P49720,P49721,P50570,P51149,P51572,P51665,P52732,P52888,P52907,P53634,P53680,P53992,P55036,P55786,P60468,P60900,P60953,P61081,P61086,P61088,P61163,P61289,P61619,P62191,P62195,P62333,P62942,P62993,P63000,P63010,P63104,P63167,P63208,P68036,P68371,P78310,Q00610,Q02241,Q03518,Q05086,Q06124,Q06323,Q07866,Q08209,Q10567,Q12846,Q13177,Q13200,Q13309,Q13409,Q13561,Q13616,Q13617,Q13618,Q13867,Q13885,Q14139,Q14203,Q14204,Q14669,Q14738,Q14807,Q14997,Q15008,Q15369,Q15370,Q15386,Q15436,Q16512,Q16763,Q5KU26,Q5T447,Q5T4S7,Q7Z6E9,Q7Z6Z7,Q8N8S7,Q8TBC4,Q92530,Q92990,Q93034,Q96CW1,Q96FJ2,Q96J02,Q99436,Q99460,Q99538,Q99661,Q9BUF5,Q9BVA1,Q9BXS5,Q9C0C9,Q9H0B6,Q9H0H5,Q9H1A4,Q9NZ08,Q9NZ32,Q9UIQ6,Q9UJW0,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6,Q9UL46,Q9ULT8,Q9UNE7,Q9UNM6,Q9Y496,Q9Y4B6,Q9Y6B6,Q9Y6G9 Termination of translesion dna synthesis 18 34 2.71906523201076 0.0032677801977150896 0.017729686332239654 P12004,P15927,P27694,P28340,P35244,P35249,P35250,P35251,P40937,P40938,P41440,P49005,Q07864,Q14258,Q14694,Q9NR33,Q9NRF9,Q9Y2S7 Positive epigenetic regulation of rrna expression 28 60 2.1172402159244266 0.0032995101193504387 0.017840109886694787 O00159,O15160,O15446,O60264,O75533,O94776,O95602,O95983,P16104,P19388,P35659,P49841,P62805,P62875,Q13185,Q13330,Q13547,Q14839,Q86YP4,Q8WXI9,Q92769,Q96KQ7,Q9BQG0,Q9GZS1,Q9H9Y6,Q9NR30,Q9NY93,Q9UIG0 Nef mediated cd4 down regulation 6 7 14.473543201607502 0.003335277029643986 0.01797152708756622 O94973,O95782,P53680,P63010,Q96CW1,Q9UI12 Atf4 activates genes in response to endoplasmic reticulum stress 13 22 3.4886800193950243 0.0034631838513911124 0.018494988725391775 O95453,P08243,Q06265,Q13868,Q15024,Q5RKV6,Q92945,Q96B26,Q9NPD3,Q9NQT4,Q9NQT5,Q9Y2L1,Q9Y3B2 Response to elevated platelet cytosolic ca2 32 71 1.9861399861399862 0.003467810386010958 0.018494988725391775 O00186,O43707,O43852,O75083,O94919,P04075,P05067,P07602,P07737,P12814,P13473,P18206,P21333,P23528,P37802,P55145,Q01518,Q08380,Q12846,Q6UXV4,Q8NBF2,Q8NBX0,Q92520,Q96JJ7,Q9BWS9,Q9NTK5,Q9NUQ9,Q9NZJ7,Q9UHQ9,Q9UNF1,Q9Y490,Q9Y6I9 Glyoxylate metabolism and glycine degradation 13 22 3.4886800193950243 0.0034631838513911124 0.018494988725391775 O00330,P00505,P08559,P09622,P10515,P11177,P11182,P23378,P30038,P36957,Q02218,Q9NR77,Q9UBQ7 Rho gtpases activate ktn1 8 11 6.435210008936551 0.0036639936955216203 0.019279000384489597 P33176,P60953,P61586,P63000,P84095,Q07866,Q86UP2,Q9H0B6 Hdr through mmej alt nhej 8 11 6.435210008936551 0.0036639936955216203 0.019279000384489597 O60934,P09874,P18887,P39748,P49916,P49959,Q92878,Q9UGN5 Establishment of sister chromatid cohesion 8 11 6.435210008936551 0.0036639936955216203 0.019279000384489597 O60216,Q14683,Q29RF7,Q7Z5K2,Q8N3U4,Q8WVM7,Q9NTI5,Q9UQE7 Biotin transport and metabolism 8 11 6.435210008936551 0.0036639936955216203 0.019279000384489597 O00763,P05165,P05166,P11498,P50747,Q13085,Q96RQ3,Q9HCC0 Polb dependent long patch base excision repair 7 9 8.444556113902848 0.0037189542211699058 0.01943773406264804 P09874,P18858,P27695,P39748,Q86W56,Q9NX46,Q9UGN5 Vldlr internalisation and degradation 7 9 8.444556113902848 0.0037189542211699058 0.01943773406264804 O94973,O95782,P09496,P53680,P63010,Q00610,Q96CW1 The role of nef in hiv 1 replication and disease pathogenesis 12 20 3.622147651006711 0.004172233721862576 0.021662458529405692 O43747,O94973,O95782,P04439,P53680,P63000,P63010,Q10567,Q13177,Q96CW1,Q9BXS5,Q9UI12 Phosphorylation of the apc c 12 20 3.622147651006711 0.004172233721862576 0.021662458529405692 P06493,P14635,P30260,P53350,Q16763,Q96DE5,Q9H1A4,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6 Formation of tc ner pre incision complex 25 53 2.159468438538206 0.0044923963949516105 0.023247780684106024 O15514,O60306,P18074,P19387,P19388,P19447,P23193,P24928,P30876,P61201,P62487,P62875,Q13098,Q13620,Q16531,Q7L5N1,Q92905,Q93009,Q99627,Q9BT78,Q9HCS7,Q9UBW8,Q9UMS4,Q9UNP9,Q9UNS2 Rho gtpases activate pkns 20 40 2.417227456258412 0.004684287002216186 0.02416105927458875 O14974,O60341,P16104,P27348,P31946,P35579,P35580,P60660,P61586,P61981,P62140,P62258,P62805,P63000,P63104,Q04917,Q16512,Q16513,Q7Z406,Q9Y3B8 Hsf1 activation 14 25 3.0741192991025095 0.0047686729472692715 0.024515669446944978 P04792,P07900,P08238,P0DMV9,P15927,P25685,P27694,P35244,P50454,P55072,P62258,Q02790,Q15185,Q92598 Rho gtpases activate cit 11 18 3.79388508170796 0.005003424917202235 0.025554952020107834 O14974,O43663,P35579,P35580,P60660,P61586,P62140,P63000,Q15058,Q15334,Q7Z406 Transferrin endocytosis and recycling 11 18 3.79388508170796 0.005003424917202235 0.025554952020107834 P02786,P21281,P21283,P36543,P38606,P61421,Q15904,Q93050,Q9UI12,Q9Y487,Q9Y5K8 Activation of atr in response to replication stress 19 38 2.4167507568113016 0.005786496130540253 0.02945852575547765 O43913,O75419,P15927,P24941,P25205,P27694,P33991,P33992,P33993,P35244,P35249,P35250,P40937,P40938,P49736,Q14566,Q7L590,Q9UBD5,Q9Y619 Regulation of plk1 activity at g2 m transition 37 87 1.7915262267343486 0.005821929448545789 0.029542994742135266 O14965,O14974,O43805,O75935,O94927,O95684,P04350,P06493,P07437,P07900,P14635,P17612,P30153,P41208,P43034,P53350,P61006,P61163,P61981,P62140,P62258,P63167,P63208,P68371,Q13409,Q13561,Q13616,Q14008,Q14203,Q14204,Q15154,Q15691,Q68CZ6,Q7Z460,Q7Z4H7,Q96CS2,Q9H6D7 Plasma lipoprotein clearance 13 23 3.139375629405841 0.005844137679390342 0.029560025423496953 O15118,O94973,O95782,P09496,P35610,P38571,P53680,P61916,P63010,Q00341,Q00610,Q8WTV0,Q96CW1 Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 10 16 4.023027051196065 0.005960703901646173 0.03005268076456977 O43747,O94973,O95782,P04439,P53680,P63010,Q10567,Q96CW1,Q9BXS5,Q9UI12 Meiosis 25 54 2.084713457224876 0.006070127496075361 0.03040881761612194 O60216,O60934,O94901,P02545,P11802,P15927,P16104,P20700,P24941,P27694,P35244,P38398,P49959,P54132,P54652,P62805,Q14683,Q8N3U4,Q8WVM7,Q8WXH0,Q92878,Q9BTC0,Q9NYB0,Q9UH99,Q9UQE7 Rho gtpases activate wasps and waves 17 33 2.567142857142857 0.006063046158730817 0.03040881761612194 O15143,O15144,O15145,P27361,P28482,P59998,P60953,P61158,P61160,P62993,P63000,Q7L576,Q92747,Q96F07,Q9NZQ3,Q9UQB8,Q9Y2A7 Protein folding 34 79 1.8286079182630908 0.006434027510100157 0.03212915648355747 O00567,O15212,O75347,P04062,P04350,P04637,P17987,P19784,P36404,P40227,P40763,P48643,P49368,P50990,P50991,P51784,P61758,P61962,P67870,P68371,P78371,Q13885,Q15477,Q15813,Q99426,Q99471,Q99832,Q9BTW9,Q9BUF5,Q9BVA1,Q9H0D6,Q9UBI6,Q9UHV9,Q9Y2T2 Dna damage bypass 23 49 2.1386895354561237 0.006780581134131209 0.03375222608989757 P12004,P15927,P27694,P28340,P35244,P35249,P35250,P35251,P40937,P40938,P41440,P49005,P55072,Q07864,Q13620,Q14258,Q14694,Q16531,Q8TAT6,Q92890,Q9NR33,Q9NRF9,Q9Y2S7 Formation of atp by chemiosmotic coupling 9 14 4.344016091183373 0.007031704622795455 0.0348914963561496 O75947,O75964,P06576,P24539,P25705,P36542,P48047,P56134,P56385 Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components 12 21 3.21923937360179 0.007158092980064326 0.03529525092056875 O43684,O60566,P30260,Q13257,Q16763,Q96DE5,Q9H1A4,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6 Processive synthesis on the c strand of the telomere 12 21 3.21923937360179 0.007158092980064326 0.03529525092056875 P12004,P15927,P18858,P27694,P28340,P35244,P39748,P49005,P51530,P54132,Q9NYB0,Q9Y2S7 Beta oxidation of lauroyl coa to decanoyl coa coa 4 4 inf 0.00740476696144675 0.03639709904560659 P30084,P40939,P55084,Q16836 L1cam interactions 38 91 1.7356574392253548 0.007503540467855903 0.03665419963230107 A0MZ66,O00560,O15020,O94973,O95239,O95782,P04350,P05556,P09496,P11142,P15311,P19784,P26038,P27361,P28482,P35241,P50570,P51812,P53680,P63000,P63010,P67870,P68371,Q00610,Q01082,Q02750,Q12955,Q13813,Q13885,Q15334,Q15418,Q16512,Q16555,Q96CW1,Q96P70,Q96S59,Q9BUF5,Q9BVA1 Meiotic synapsis 16 31 2.5767025089605733 0.007503825307377961 0.03665419963230107 O60216,O94901,P02545,P16104,P20700,P38398,P54652,P62805,Q14683,Q8N3U4,Q8WVM7,Q8WXH0,Q9BTC0,Q9NYB0,Q9UH99,Q9UQE7 Deadenylation of mrna 14 26 2.817550929035147 0.0075731037148639635 0.03687772243759843 A5YKK6,O95453,P06730,P11940,P23588,P38919,P60842,Q04637,Q14240,Q92600,Q9C0C2,Q9H074,Q9HBH5,Q9UIV1 Retrograde neurotrophin signalling 8 12 4.825737265415549 0.00816932181827279 0.03953548336744363 O94973,O95782,P09496,P50570,P53680,P63010,Q00610,Q96CW1 Wnt5a dependent internalization of fzd2 fzd5 and ror2 8 12 4.825737265415549 0.00816932181827279 0.03953548336744363 O94973,O95782,P09496,P09497,P53680,P63010,Q00610,Q96CW1 Rho gtpases activate rocks 11 19 3.319188191881919 0.008758898168252423 0.042128688122146624 O14974,O75116,P23528,P35579,P35580,P60660,P61586,P62140,Q13464,Q16512,Q7Z406 Insertion of tail anchored proteins into the endoplasmic reticulum membrane 11 19 3.319188191881919 0.008758898168252423 0.042128688122146624 O43681,O43765,P05067,P09601,P46379,P50402,P51648,P60468,Q13190,Q7L5D6,Q9P0L0 Fatty acyl coa biosynthesis 15 29 2.5876961466481117 0.009298767344934806 0.04458858469987088 O00767,O60488,O95573,P33121,P49327,P50897,P53007,P53396,Q13085,Q4G176,Q53GQ0,Q9NZ01,Q9P035,Q9UMR5,Q9Y6X9 Rhoc gtpase cycle 32 75 1.8003771213073538 0.009358908528809998 0.04474014808894536 O60610,O75116,O75955,O95292,P02786,P14923,P27105,P28288,P41440,P42166,P42167,P46940,P49257,P52565,P61586,P63167,Q07021,Q07960,Q13190,Q13464,Q14254,Q14739,Q16512,Q16513,Q5T8D3,Q8TAA9,Q92888,Q9H0H5,Q9H2G2,Q9NQW6,Q9NSV4,Q9UDY2 Beta oxidation of decanoyl coa to octanoyl coa coa 5 6 12.05724807499163 0.009843762760845986 0.04677278790608032 P11310,P30084,P40939,P55084,Q16836 Phenylalanine and tyrosine metabolism 5 6 12.05724807499163 0.009843762760845986 0.04677278790608032 O43708,P09417,P16930,P61457,Q7L266 Dna repair 104 291 1.351282089264817 0.009881646779406946 0.046810943051692123 O15514,O60264,O60306,O60934,O96017,O96019,O96028,P04637,P09874,P12004,P12956,P13010,P13051,P15927,P16104,P18074,P18858,P18887,P19387,P19388,P19447,P20585,P23193,P24928,P24941,P27694,P27695,P28340,P29372,P30876,P35244,P35249,P35250,P35251,P38398,P39748,P40937,P40938,P41208,P41440,P43246,P49005,P49916,P49959,P51530,P52292,P52701,P53041,P54132,P54727,P55072,P60510,P61088,P61201,P62487,P62805,P62875,P78527,Q04323,Q07864,Q12888,Q13098,Q13620,Q14258,Q14676,Q14694,Q16531,Q16658,Q5UIP0,Q6P6C2,Q7L5N1,Q86W56,Q86WJ1,Q8N3C0,Q8TAT6,Q92878,Q92890,Q92905,Q93009,Q96T60,Q99627,Q9BT78,Q9BXW9,Q9C0B1,Q9H1I8,Q9HCS7,Q9NR33,Q9NRF9,Q9NVI1,Q9NWV8,Q9NX46,Q9NXR7,Q9NY27,Q9NYB0,Q9UBW8,Q9UGN5,Q9UIG0,Q9UMS4,Q9UNP9,Q9UNS1,Q9UNS2,Q9UQ84,Q9Y265,Q9Y2S7 Glutathione synthesis and recycling 6 8 7.2357669122572 0.010013357712528708 0.04729200269049703 O75223,P48506,P48507,P48637,Q8WUX2,Q96KP4 Translesion synthesis by polk 10 17 3.447829836159816 0.010700303484668503 0.050384612204084724 P12004,P15927,P27694,P35244,P35249,P35250,P35251,P40937,P40938,P41440 Class i mhc mediated antigen processing presentation 105 295 1.342624833646291 0.010891248918159836 0.05113017456190007 A0AVT1,O00161,O00231,O00232,O00487,O14818,O15111,O43242,O75396,O75832,O94822,O94874,O94979,O95376,O95486,O95487,P01889,P04439,P09429,P10321,P17980,P19474,P20618,P22314,P25786,P25787,P25788,P25789,P27797,P27824,P28066,P28070,P28072,P28074,P29144,P30101,P30260,P35998,P43686,P48556,P49720,P49721,P51572,P51665,P52888,P53992,P55036,P55786,P60468,P60900,P61081,P61086,P61088,P61289,P61619,P62191,P62195,P62333,P63208,P68036,Q03518,Q05086,Q06323,Q12846,Q13200,Q13309,Q13616,Q13617,Q13618,Q13867,Q14139,Q14669,Q14997,Q15008,Q15369,Q15370,Q15386,Q15436,Q16763,Q5T447,Q5T4S7,Q7Z6E9,Q7Z6Z7,Q8TBC4,Q92530,Q92990,Q93034,Q96J02,Q99436,Q99460,Q9C0C9,Q9H1A4,Q9NZ08,Q9UIQ6,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6,Q9UL46,Q9ULT8,Q9UNE7,Q9UNM6,Q9Y4B6,Q9Y6B6 Epigenetic regulation of gene expression 41 102 1.6269172439462032 0.011974555583103872 0.05604806911733395 O00159,O00422,O15160,O15446,O43159,O60264,O75533,O94776,O95602,O95983,P16104,P17480,P18074,P19388,P19447,P26358,P35659,P49841,P62805,P62875,Q13185,Q13330,Q13547,Q14839,Q15022,Q15393,Q86YP4,Q8WXI9,Q92769,Q96EB6,Q96KQ7,Q96ST3,Q96T88,Q9BQG0,Q9GZS1,Q9H9Y6,Q9NR30,Q9NY93,Q9UHR5,Q9UIF9,Q9UIG0 Signaling by fgfr2 23 51 1.9853726603473993 0.01209490491146154 0.056442889586820526 O15514,P09651,P19174,P19387,P19388,P22681,P24928,P26599,P27361,P28482,P30153,P30876,P31483,P31943,P35269,P52272,P52597,P62487,P62875,P62993,Q01085,Q06124,Q09161 Apoptotic cleavage of cellular proteins 17 35 2.2812698412698413 0.012592515796430365 0.05859069664333178 P02545,P08670,P15924,P20700,P35222,P35611,P51572,Q07157,Q13464,Q13813,Q14126,Q15149,Q16625,Q9P289,Q9UDY2,Q9UJU6,Q9UKV3 Metabolism of lipids 172 508 1.2467240797028032 0.0132361615558935 0.06140325834213316 A0FGR8,O00116,O00154,O00443,O00763,O00767,O14734,O14735,O15228,O15254,O15269,O15270,O43681,O43772,O43808,O60244,O60488,O60664,O75131,O75448,O75521,O75845,O95292,O95470,O95486,O95487,O95573,O95674,O95772,O95864,O96017,P04062,P05165,P05166,P06280,P06865,P07602,P07686,P09110,P09960,P10619,P11310,P14324,P15121,P16152,P16278,P17612,P17900,P19784,P20338,P20339,P22033,P22059,P22307,P22570,P23786,P24752,P27544,P30084,P30536,P33121,P34913,P35610,P35790,P35914,P37268,P38435,P40939,P42126,P42356,P42765,P43304,P48163,P48449,P48651,P48739,P49327,P49748,P50416,P50897,P51648,P51659,P53007,P53396,P53992,P55084,P61106,P62136,P62140,P62826,P67870,Q01581,Q01968,Q06136,Q10713,Q13085,Q13510,Q13614,Q13907,Q14534,Q14739,Q14849,Q14914,Q14974,Q15067,Q15126,Q15165,Q15185,Q15392,Q15436,Q15648,Q15738,Q15800,Q16836,Q16850,Q16881,Q4G176,Q53GQ0,Q53H12,Q5T8D3,Q6IAN0,Q709F0,Q86X55,Q8IV08,Q8IVS2,Q8IY17,Q8N8N7,Q8N9F7,Q8NBQ5,Q8NCC3,Q8NF37,Q8TBX8,Q8WVX9,Q92604,Q96G23,Q96N66,Q96ST3,Q96SU4,Q96T51,Q99538,Q99570,Q99829,Q99943,Q9BSJ8,Q9BTU6,Q9BWD1,Q9BY49,Q9BZF1,Q9H7Z7,Q9HCL2,Q9NPH0,Q9NPJ3,Q9NPJ6,Q9NQZ5,Q9NTJ5,Q9NUQ2,Q9NXE4,Q9NZ01,Q9NZJ7,Q9P035,Q9P0L0,Q9UBF8,Q9UBM7,Q9UG56,Q9UJ83,Q9ULK4,Q9UMR5,Q9Y2W1,Q9Y2X0,Q9Y305,Q9Y6B6,Q9Y6X9 Reproduction 25 57 1.8884816312773847 0.013722556190600262 0.06347188232112451 O60216,O60934,O94901,P02545,P11802,P15927,P16104,P20700,P24941,P27694,P35244,P38398,P49959,P54132,P54652,P62805,Q14683,Q8N3U4,Q8WVM7,Q8WXH0,Q92878,Q9BTC0,Q9NYB0,Q9UH99,Q9UQE7 Iron uptake and transport 18 38 2.17404169468729 0.014118868702853372 0.06511290037080614 O76003,P02786,P09601,P21281,P21283,P21399,P30519,P36543,P38606,P61421,P63208,Q13616,Q15904,Q86VP6,Q93050,Q9UI12,Q9Y487,Q9Y5K8 Sensory processing of sound by outer hair cells of the cochlea 13 25 2.6154190444220657 0.01434365291961123 0.06595556533123287 O00159,O14936,P15311,P26038,P35241,P35579,Q00013,Q01082,Q12792,Q13813,Q14651,Q6IBS0,Q9Y2J2 Formation of the early elongation complex 16 33 2.2729285262492094 0.01560884184498565 0.07135470557707725 O00267,O15514,P18074,P18615,P19387,P19388,P19447,P24928,P30876,P35269,P62487,P62875,Q09161,Q8IXH7,Q8WX92,Q9H3P2 Mitochondrial fatty acid beta oxidation 16 33 2.2729285262492094 0.01560884184498565 0.07135470557707725 O00154,P05165,P05166,P11310,P22033,P30084,P40939,P42126,P42765,P49748,P55084,Q16836,Q709F0,Q8IVS2,Q9NPJ3,Q9Y305 Wnt5a dependent internalization of fzd4 8 13 3.860053619302949 0.01581386914400311 0.07187288932694746 O94973,O95782,P09496,P09497,P53680,P63010,Q00610,Q96CW1 Early phase of hiv life cycle 8 13 3.860053619302949 0.01581386914400311 0.07187288932694746 O75475,O75531,P12956,P13010,P17096,P18858,P39748,P52294 Regulation of cholesterol biosynthesis by srebp srebf 24 55 1.8710546908964438 0.01669516983876425 0.07565903556989116 O00763,O00767,O75845,O95486,O95487,P14324,P37268,P48449,P49327,P53992,P62826,Q01581,Q13085,Q13907,Q14534,Q14974,Q15126,Q15436,Q15648,Q16850,Q86X55,Q9HCL2,Q9UBM7,Q9Y6B6 Neddylation 68 185 1.4086662691313854 0.017042948355548027 0.07701251591210174 O00231,O00232,O00487,O14818,O43242,O60826,O75832,O94888,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61081,P61201,P61289,P61962,P61964,P62191,P62195,P62333,P63208,Q06323,Q13098,Q13200,Q13309,Q13564,Q13616,Q13617,Q13618,Q13620,Q14997,Q15008,Q15291,Q15369,Q15370,Q16531,Q7L5N1,Q86VP6,Q8TBC4,Q92530,Q92905,Q93034,Q99436,Q99460,Q99627,Q9BT78,Q9BTE7,Q9BW61,Q9NV06,Q9UBW8,Q9UL46,Q9UNM6,Q9UNS2,Q9Y5A7 Association of tric cct with target proteins during biosynthesis 17 36 2.1609022556390975 0.017457295820703007 0.07865816047948941 O00567,P04062,P04637,P17987,P40227,P40763,P48643,P49368,P50990,P50991,P51784,P61962,P78371,Q15477,Q99832,Q9H0D6,Q9Y2T2 Vxpx cargo targeting to cilium 10 18 3.016431924882629 0.0178214016945027 0.07961241554695223 O00471,O60645,P18085,P61006,Q8IYI6,Q8TAG9,Q92538,Q96A65,Q96KP1,Q9UPT5 Post chaperonin tubulin folding pathway 10 18 3.016431924882629 0.0178214016945027 0.07961241554695223 O75347,P04350,P36404,P68371,Q13885,Q15813,Q99426,Q9BTW9,Q9BUF5,Q9BVA1 Defects in vitamin and cofactor metabolism 10 18 3.016431924882629 0.0178214016945027 0.07961241554695223 P05165,P05166,P11498,P22033,P50747,Q13085,Q96EY8,Q96RQ3,Q99707,Q9HCC0 Lysine catabolism 7 11 4.221105527638191 0.019036444928572413 0.08431962047458064 P09622,P36957,P49419,Q02218,Q92947,Q9BQT8,Q9UDR5 Suppression of phagosomal maturation 7 11 4.221105527638191 0.019036444928572413 0.08431962047458064 O14964,P20339,P51149,P52294,Q14974,Q9H267,Q9UI12 Erks are inactivated 7 11 4.221105527638191 0.019036444928572413 0.08431962047458064 P27361,P28482,P30153,P30154,P51452,Q14738,Q8IV63 Recruitment of numa to mitotic centrosomes 36 90 1.6125394677492106 0.019257576444028354 0.08505881651897594 O43805,O75935,O94927,O95684,P04350,P06493,P07437,P07900,P17612,P30153,P41208,P43034,P53350,P61163,P61981,P62258,P63167,P68371,Q13409,Q13561,Q13885,Q14008,Q14203,Q14204,Q14980,Q15154,Q15691,Q68CZ6,Q7Z460,Q7Z4H7,Q96CS2,Q96CW5,Q9BSJ2,Q9BUF5,Q9BVA1,Q9H6D7 Diseases of programmed cell death 23 53 1.8524980352531717 0.020308285400649287 0.08944772895566877 O15446,P02545,P04179,P04637,P05067,P07384,P09884,P16104,P17655,P20700,P20810,P26358,P32119,P49642,P49643,P62258,P62805,Q00535,Q07021,Q08379,Q13546,Q14181,Q15022 Aggrephagy 16 34 2.1463560334528076 0.021609312711955573 0.09491149112702056 O43237,P04350,P07900,P08670,P55072,P61088,P63167,P68371,Q13409,Q13885,Q14204,Q96FJ2,Q99497,Q9BUF5,Q9BVA1,Q9Y6G9 Piwi interacting rna pirna biogenesis 9 16 3.102006608878885 0.022135401775044226 0.09614490300074612 O15514,P07900,P19387,P19388,P24928,P30876,P62487,P62875,Q9Y2W6 Regulation of pyruvate dehydrogenase pdh complex 9 16 3.102006608878885 0.022135401775044226 0.09614490300074612 O00330,O43708,P08559,P09622,P10515,P11177,Q15118,Q15120,Q8NCN5 Ros and rns production in phagocytes 9 16 3.102006608878885 0.022135401775044226 0.09614490300074612 P21281,P21283,P36543,P38606,P61421,Q93050,Q9UI12,Q9Y487,Q9Y5K8 Depolymerisation of the nuclear lamina 9 16 3.102006608878885 0.022135401775044226 0.09614490300074612 P02545,P06493,P14635,P20700,P42166,P42167,P50402,Q8NC56,Q9Y2U8 Trna modification in the mitochondrion 6 9 4.8231748158071 0.02260216469566501 0.09709642258302119 O15091,O75648,Q7L0Y3,Q969Y2,Q99714,Q9Y606 Apoptotic cleavage of cell adhesion proteins 6 9 4.8231748158071 0.02260216469566501 0.09709642258302119 P15924,P35222,Q07157,Q14126,Q16625,Q9UDY2 Mitochondrial fatty acid beta oxidation of saturated fatty acids 6 9 4.8231748158071 0.02260216469566501 0.09709642258302119 P11310,P30084,P40939,P49748,P55084,Q16836 Integration of provirus 6 9 4.8231748158071 0.02260216469566501 0.09709642258302119 O75475,O75531,P12956,P13010,P17096,P52294 Organelle biogenesis and maintenance 94 268 1.3104955458778547 0.02299999051894929 0.09853547850741118 A0AVF1,A6NIH7,O00411,O00471,O43805,O43924,O60645,O75431,O75695,O75935,O75947,O75964,O94927,O95684,P00367,P04179,P04350,P06493,P06576,P07437,P07900,P17612,P17987,P18085,P24539,P25705,P30153,P36405,P36542,P38646,P41208,P43034,P48047,P48643,P48735,P49368,P50990,P50991,P51610,P53350,P54619,P56134,P56385,P61006,P61163,P61981,P62258,P63167,P68371,P78371,Q00059,Q04837,Q10713,Q13409,Q13505,Q13561,Q13885,Q14008,Q14203,Q14204,Q15019,Q15154,Q15648,Q15691,Q16539,Q16891,Q5XKP0,Q68CZ6,Q6UXV4,Q7Z460,Q7Z4H7,Q86X55,Q8IYI6,Q8NCM8,Q8TAG9,Q8WVM0,Q92538,Q92973,Q96A65,Q96CS2,Q96FJ2,Q96KP1,Q96RR1,Q9BUF5,Q9BUR5,Q9BVA1,Q9BW83,Q9H6D7,Q9NQ48,Q9NVH1,Q9NX63,Q9UPT5,Q9Y496,Q9Y512 Semaphorin interactions 21 48 1.8788660757694753 0.0235043571375852 0.10042188553605884 O75116,P05556,P07900,P08238,P23528,P35579,P35580,P49841,P60660,P61586,P63000,Q00535,Q13177,Q13464,Q14195,Q16512,Q16555,Q7Z406,Q9BPU6,Q9NWH9,Q9Y490 Formyl peptide receptors bind formyl peptides and many other ligands 3 3 inf 0.025251518781288083 0.10759342785070575 P04083,P05067,Q9NRV9 Sensory processing of sound 18 40 1.9758513174787553 0.025502211985177155 0.10836712301560374 O00159,O14936,P15311,P20020,P26038,P35241,P35579,P47755,P47756,P52907,P56545,Q00013,Q01082,Q12792,Q13813,Q14651,Q6IBS0,Q9Y2J2 Hur elavl1 binds and stabilizes mrna 5 7 6.027787077335119 0.026114977089362945 0.1091954242029896 O14980,P35658,P39687,Q01105,Q15717 Cd28 dependent vav1 pathway 5 7 6.027787077335119 0.026114977089362945 0.1091954242029896 P60953,P62993,P63000,Q13177,Q16512 2 ltr circle formation 5 7 6.027787077335119 0.026114977089362945 0.1091954242029896 O75475,O75531,P12956,P13010,P17096 Tysnd1 cleaves peroxisomal proteins 5 7 6.027787077335119 0.026114977089362945 0.1091954242029896 O00116,P09110,P22307,P51659,Q15067 Attachment of gpi anchor to upar 5 7 6.027787077335119 0.026114977089362945 0.1091954242029896 O43292,Q92643,Q969N2,Q96S52,Q9H490 Aspartate and asparagine metabolism 5 7 6.027787077335119 0.026114977089362945 0.1091954242029896 O75746,P00505,P08243,P17174,Q9UJS0 Peroxisomal lipid metabolism 12 24 2.4134228187919464 0.02636006000020437 0.1096354750141126 O14734,O15254,O43808,O75521,P09110,P22307,P51648,P51659,Q15067,Q5T8D3,Q9BY49,Q9UJ83 Microrna mirna biogenesis 12 24 2.4134228187919464 0.02636006000020437 0.1096354750141126 O15514,O75569,P19387,P19388,P24928,P30876,P62487,P62826,P62875,Q8WYQ5,Q9HAV4,Q9UPY3 Signaling by notch 56 152 1.4122388737511353 0.027022954021121974 0.11209521668020966 O00231,O00232,O00487,O14818,O43242,O75832,P04637,P16104,P16615,P17980,P20618,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P35998,P42224,P43686,P48556,P49720,P49721,P51665,P55036,P60900,P61289,P62191,P62195,P62333,P62805,P63104,P63208,P67809,Q06323,Q13200,Q13547,Q13573,Q13616,Q15008,Q15363,Q15398,Q92530,Q92542,Q92769,Q96J02,Q99436,Q99460,Q9H488,Q9HCE1,Q9UBV2,Q9UL46,Q9UNM6,Q9Y6A5 Dna double strand break repair 51 137 1.4352735582739615 0.027731699607089252 0.11473167541930329 O60264,O60934,O96017,O96028,P04637,P09874,P12004,P12956,P13010,P15927,P16104,P18887,P24941,P27694,P28340,P35244,P35249,P35250,P35251,P38398,P39748,P40937,P40938,P41440,P49005,P49916,P49959,P51530,P52292,P53041,P54132,P60510,P61088,P62805,P78527,Q04323,Q07864,Q12888,Q14676,Q5UIP0,Q92878,Q9NR33,Q9NRF9,Q9NWV8,Q9NXR7,Q9NY27,Q9UGN5,Q9UIG0,Q9UNS1,Q9UQ84,Q9Y2S7 Wax and plasmalogen biosynthesis 4 5 9.642570281124499 0.028340379673602263 0.115123614839918 O00116,O15228,Q6IAN0,Q8WVX9 Maturation of sars cov 1 spike protein 4 5 9.642570281124499 0.028340379673602263 0.115123614839918 P14314,P27824,Q13724,Q14697 Beta oxidation of hexanoyl coa to butanoyl coa 4 5 9.642570281124499 0.028340379673602263 0.115123614839918 P30084,P40939,P55084,Q16836 Mitochondrial fatty acid beta oxidation of unsaturated fatty acids 4 5 9.642570281124499 0.028340379673602263 0.115123614839918 P11310,P40939,P42126,P55084 Uptake and function of diphtheria toxin 4 5 9.642570281124499 0.028340379673602263 0.115123614839918 P07900,P08238,P13639,Q16881 Scavenging by class f receptors 4 5 9.642570281124499 0.028340379673602263 0.115123614839918 P07900,P27797,Q92598,Q9Y4L1 Trna processing in the mitochondrion 4 5 9.642570281124499 0.028340379673602263 0.115123614839918 O15091,Q7L0Y3,Q99714,Q9BQ52 Cargo recognition for clathrin mediated endocytosis 31 78 1.5942500736525183 0.031162150482484312 0.12625904898329562 O14964,O94973,O95782,P02786,P09496,P09497,P11717,P20645,P22681,P42566,P51809,P53680,P61201,P62993,P63010,Q00610,Q13098,Q13492,Q14108,Q7L5N1,Q92783,Q92905,Q96CW1,Q96D71,Q99627,Q99961,Q9BT78,Q9NVZ3,Q9UBC2,Q9UBW8,Q9UNS2 Rac2 gtpase cycle 32 81 1.5785990071704357 0.031520588184647494 0.12738217080805997 O15173,O95292,P02786,P05556,P42166,P42167,P46940,P49257,P50402,P51149,P52565,P60953,Q07960,Q13112,Q13177,Q13505,Q14126,Q14739,Q16512,Q5T2T1,Q68EM7,Q6IAA8,Q7L576,Q86XL3,Q8TAA9,Q9BSJ8,Q9H0H5,Q9NSV4,Q9UH62,Q9Y2A7,Q9Y2U8,Q9Y512 Attenuation phase 11 22 2.412948674941295 0.032992461307994735 0.1329876075345392 P04792,P07900,P08238,P0DMV9,P11142,P25685,P50454,P54652,Q02790,Q15185,Q92598 Translation of sars cov 2 structural proteins 18 41 1.8896815882576532 0.033290055389940704 0.13350078478625838 P04843,P04844,P14314,P27824,P39656,P46977,P48729,P49840,P49841,P61803,P78362,Q10472,Q13724,Q14697,Q16706,Q96SB4,Q99873,Q9H0U3 Hsf1 dependent transactivation 14 30 2.111987911349899 0.03324008469696849 0.13350078478625838 P04792,P07900,P08238,P0DMV9,P11142,P25685,P42345,P50454,P54652,Q02790,Q13555,Q15185,Q92598,Q96B36 Alpha linolenic omega3 and linoleic omega6 acid metabolism 7 12 3.3764154103852597 0.03425041728316397 0.13630622918782007 O14734,O95864,P09110,P22307,P33121,P51659,Q15067 Mecp2 regulates neuronal receptors and channels 7 12 3.3764154103852597 0.03425041728316397 0.13630622918782007 P18031,P51608,Q13451,Q13547,Q92769,Q96ST3,Q9NWH9 Metabolism of steroid hormones 7 12 3.3764154103852597 0.03425041728316397 0.13630622918782007 O95772,P15121,P22570,P30536,Q14849,Q53GQ0,Q8NBQ5 Metabolism of porphyrins 9 17 2.713878645658733 0.034999887351576275 0.13893626168929518 P06132,P08397,P09601,P22830,P30519,P36551,P50336,P53004,Q7KZN9 Transcription of the hiv genome 27 67 1.6309274873524453 0.035471846120852885 0.1404541785795387 O00267,O15514,O43148,P18074,P18615,P19387,P19388,P19447,P23193,P24928,P29083,P30876,P35269,P50750,P62487,P62875,Q00403,Q08945,Q09161,Q14241,Q15369,Q15370,Q8IXH7,Q8WX92,Q92804,Q9H3P2,Q9Y5B9 Apc cdc20 mediated degradation of nek2a 12 25 2.227465152297367 0.03745212807449744 0.1478602124015526 O43684,O60566,P30260,Q13257,Q16763,Q96DE5,Q9H1A4,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6 Recruitment of mitotic centrosome proteins and complexes 32 82 1.5468108108108107 0.037530844729475724 0.1478602124015526 O43805,O75935,O94927,O95684,P04350,P06493,P07437,P07900,P17612,P30153,P41208,P43034,P53350,P61163,P61981,P62258,P63167,P68371,Q13409,Q13561,Q14008,Q14203,Q14204,Q15154,Q15691,Q68CZ6,Q7Z460,Q7Z4H7,Q96CS2,Q96CW5,Q9BSJ2,Q9H6D7 Parasite infection 21 50 1.7488016341879549 0.037828282840152015 0.1486585150209483 O00159,O15143,O15144,O15145,P27361,P28482,P35579,P46108,P59998,P60953,P61158,P61160,P62993,P63000,Q7L576,Q92747,Q96F07,Q96JJ3,Q9NZQ3,Q9UQB8,Q9Y2A7 Metabolism of water soluble vitamins and cofactors 35 91 1.5108217788298952 0.03805913666192636 0.14912123548772271 O00763,O00764,P00374,P00387,P05165,P05166,P11166,P11498,P11586,P13995,P22033,P34896,P34897,P41440,P43490,P49327,P50747,P78417,Q13057,Q13085,Q4G0N4,Q6UB35,Q8NCW5,Q8NFF5,Q96EY8,Q96RQ3,Q99707,Q9BQG2,Q9H2D1,Q9HC21,Q9HCC0,Q9NQX3,Q9NRN7,Q9NVE7,Q9Y697 Homology directed repair 40 106 1.46546768497988 0.03813623433072501 0.14912123548772271 O60934,O96028,P09874,P12004,P15927,P16104,P18887,P24941,P27694,P28340,P35244,P35249,P35250,P35251,P38398,P39748,P40937,P40938,P41440,P49005,P49916,P49959,P51530,P54132,P60510,P61088,P62805,Q07864,Q12888,Q14676,Q92878,Q9NR33,Q9NRF9,Q9NWV8,Q9NXR7,Q9NY27,Q9UGN5,Q9UNS1,Q9UQ84,Q9Y2S7 Intracellular signaling by second messengers 81 233 1.2909562638991845 0.04032235927647066 0.1572772620534975 O00231,O00232,O00487,O14818,O15111,O43242,O43815,O43865,O60341,O75832,O94776,O95983,P04637,P10644,P13861,P17612,P17980,P19174,P19784,P20618,P25786,P25787,P25788,P25789,P27361,P28066,P28070,P28072,P28074,P28482,P30153,P30154,P31751,P35998,P42345,P43686,P48556,P49720,P49721,P49840,P49841,P51665,P52292,P55036,P60900,P61289,P62191,P62195,P62333,P62993,P63000,P67870,P84095,Q06124,Q06323,Q13200,Q13330,Q13547,Q13555,Q14738,Q14839,Q14997,Q15008,Q15022,Q6IAA8,Q86YP4,Q8TBX8,Q8WXI9,Q92530,Q92769,Q93009,Q96B36,Q99436,Q99460,Q9HCE1,Q9NWH9,Q9UKL0,Q9UL46,Q9UNE7,Q9UNM6,Q9Y2Q5 Rnd3 gtpase cycle 17 39 1.8654545454545455 0.04078915959300289 0.15870323136930156 O43396,O75976,P12277,P15924,P38159,Q03001,Q07065,Q13464,Q13492,Q14160,Q14254,Q86UP2,Q8TAA9,Q9NNW5,Q9NYL9,Q9Y2I1,Q9Y2U8 Erk mapk targets 10 20 2.4124748490945676 0.041416878732585316 0.16034979222887352 P27361,P28482,P30153,P30154,P51452,P51812,Q14738,Q15418,Q16539,Q8IV63 Aberrant regulation of mitotic exit in cancer due to rb1 defects 10 20 2.4124748490945676 0.041416878732585316 0.16034979222887352 P30260,Q13309,Q16763,Q96DE5,Q9H1A4,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6 Met receptor recycling 6 10 3.6168787675820497 0.042624447794497575 0.1642140888004231 P20338,P46108,P46109,P62330,P62993,Q9NWH9 Sting mediated induction of host immune responses 6 10 3.6168787675820497 0.042624447794497575 0.1642140888004231 P12956,P13010,P19474,P49959,P78527,Q9UJV9 Mrna decay by 5 to 3 exoribonuclease 8 15 2.7564151666028343 0.044079179115471025 0.16816582202690647 P26196,P62312,Q6P2E9,Q86TB9,Q96F86,Q9UK45,Q9Y333,Q9Y4Z0 Formation of senescence associated heterochromatin foci sahf 8 15 2.7564151666028343 0.044079179115471025 0.16816582202690647 P04637,P07305,P10412,P16402,P16403,P17096,P20700,Q96L91 Synthesis of pips at the golgi membrane 8 15 2.7564151666028343 0.044079179115471025 0.16816582202690647 O00443,P42356,Q01968,Q10713,Q99570,Q9BTU6,Q9NTJ5,Q9UBF8 Metabolism of folate and pterines 8 15 2.7564151666028343 0.044079179115471025 0.16816582202690647 P00374,P11586,P13995,P34896,P34897,P41440,Q6UB35,Q9H2D1 Signaling by fgfr in disease 20 48 1.7246683330128822 0.04578731443419638 0.1742585170699513 O15164,O15514,O94905,O95429,O95684,P19174,P19387,P19388,P24928,P30876,P35269,P40763,P42224,P62487,P62875,P62993,Q09161,Q16630,Q92614,Q9UBW7 Apc c cdc20 mediated degradation of cyclin b 11 23 2.211562115621156 0.04686171931152261 0.1774859320784238 P06493,P14635,P30260,Q16763,Q96DE5,Q9H1A4,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6 E2f mediated regulation of dna replication 11 23 2.211562115621156 0.04686171931152261 0.1774859320784238 O43913,P06493,P09884,P14635,P30153,P30154,P49642,P49643,Q14181,Q9UBD5,Q9Y619 Signaling by fgfr 23 57 1.6336457115685614 0.04896586433346553 0.1850083741563228 O15514,P09651,P19174,P19387,P19388,P22681,P24928,P26599,P27361,P28482,P30153,P30876,P31483,P31943,P35269,P52272,P52597,P62487,P62875,P62993,Q01085,Q06124,Q09161 Factors involved in megakaryocyte development and platelet production 43 117 1.404919670433404 0.04980364869509984 0.18772144508153016 O00139,O60341,O95140,O95235,O95239,P04350,P04637,P10644,P13861,P17612,P20339,P24941,P27144,P33176,P45973,P47755,P47756,P52732,P52907,P60953,P63000,P68371,Q00535,Q02241,Q07866,Q12756,Q13547,Q13885,Q14807,Q8IWA4,Q92667,Q92769,Q96N67,Q96ST3,Q99661,Q9BUF5,Q9BVA1,Q9BW19,Q9H0B6,Q9H0H5,Q9H4M9,Q9UKL0,Q9Y496 Dna damage recognition in gg ner 16 37 1.8389656938044034 0.04998794493519239 0.18796426296974023 O96019,P09874,P41208,P54727,P61201,Q13098,Q13620,Q16531,Q7L5N1,Q92905,Q99627,Q9BT78,Q9UBW8,Q9UGN5,Q9UNS2,Q9Y265 Processing of dna double strand break ends 26 66 1.5699932569116655 0.05084918698241167 0.19074527557038637 O60934,O96028,P15927,P16104,P24941,P27694,P35244,P35249,P35250,P38398,P40937,P40938,P49959,P51530,P54132,P60510,P61088,P62805,Q12888,Q14676,Q92878,Q9NWV8,Q9NXR7,Q9NY27,Q9UNS1,Q9UQ84 Signaling by fgfr2 iiia tm 9 18 2.4120013409319476 0.05217837300980973 0.1929615303759001 O15514,P19387,P19388,P24928,P30876,P35269,P62487,P62875,Q09161 Plasma lipoprotein assembly remodeling and clearance 17 40 1.7840993788819877 0.05208820782323654 0.1929615303759001 O15118,O94973,O95782,P07237,P09496,P17612,P35610,P38571,P53680,P61916,P63010,Q00341,Q00610,Q8WTV0,Q96CW1,Q9BU23,Q9Y6B6 Fcgamma receptor fcgr dependent phagocytosis 28 72 1.537234695129432 0.05157064063285076 0.1929615303759001 O00159,O15143,O15144,O15145,O43865,P07900,P08238,P19174,P23528,P27361,P28482,P35579,P46108,P59998,P60953,P61158,P61160,P62993,P63000,Q16512,Q7L576,Q8IV08,Q92747,Q96F07,Q96JJ3,Q9NZQ3,Q9UQB8,Q9Y2A7 Tp53 regulates metabolic genes 32 84 1.486902286902287 0.0520831740434214 0.1929615303759001 O00483,O43819,O75880,O94925,P00390,P00403,P04637,P06744,P09669,P10606,P11413,P13073,P15954,P20674,P27348,P30044,P31751,P31946,P32119,P42345,P42704,P54619,P61981,P62258,P63104,Q04917,Q16881,Q6IAA8,Q9HCE1,Q9NQ88,Q9Y2Q5,Q9Y3B8 Rnd2 gtpase cycle 17 40 1.7840993788819877 0.05208820782323654 0.1929615303759001 O43396,P02786,P38159,P51648,Q03001,Q07065,Q07960,Q08378,Q14160,Q15058,Q86UP2,Q8TAA9,Q9BTT6,Q9NNW5,Q9Y266,Q9Y2I1,Q9Y2U8 Fgfr2 mutant receptor activation 9 18 2.4120013409319476 0.05217837300980973 0.1929615303759001 O15514,P19387,P19388,P24928,P30876,P35269,P62487,P62875,Q09161 Irf3 mediated induction of type i ifn 5 8 4.017966744782949 0.052951009383577295 0.19308647142662605 P12956,P13010,P49959,P78527,Q9UJV9 Miro gtpase cycle 5 8 4.017966744782949 0.052951009383577295 0.19308647142662605 O95140,P52306,Q8IWA4,Q8IXI1,Q8IXI2 Chrebp activates metabolic gene expression 5 8 4.017966744782949 0.052951009383577295 0.19308647142662605 O00763,P49327,P53396,Q13085,Q99943 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 5 8 4.017966744782949 0.052951009383577295 0.19308647142662605 P05141,P12235,P12236,P36404,Q99808 Pregnenolone biosynthesis 5 8 4.017966744782949 0.052951009383577295 0.19308647142662605 O95772,P15121,P22570,P30536,Q14849 Hyaluronan uptake and degradation 5 8 4.017966744782949 0.052951009383577295 0.19308647142662605 O75330,P06865,P07686,P08236,Q9UHD1 Mrna capping 13 29 1.9604733131923464 0.05532021236437697 0.20125775635114404 O00267,O15514,O43148,P18074,P19387,P19388,P19447,P24928,P30876,P35269,P62487,P62875,Q09161 Pentose phosphate pathway 7 13 2.813288665549972 0.0557597234463358 0.2023871443607744 O95336,P11413,P11908,P29401,P37837,P52209,Q96G03 Platelet activation signaling and aggregation 54 152 1.3327266917658827 0.057014400059201005 0.20646323162315747 O00186,O43707,O43852,O75083,O94919,P04075,P04899,P05067,P07602,P07737,P08754,P12814,P13473,P18031,P18206,P21333,P23528,P27361,P28482,P37802,P41240,P46108,P55145,P60953,P61586,P62993,P63000,P63096,P63104,P84095,Q01518,Q06124,Q08380,Q12846,Q13685,Q14344,Q16539,Q6UXV4,Q8N2K0,Q8NBF2,Q8NBX0,Q8NCG7,Q92520,Q96JJ7,Q9BV23,Q9BWS9,Q9NTK5,Q9NUQ9,Q9NZJ7,Q9UBI6,Q9UHQ9,Q9UNF1,Q9Y490,Q9Y6I9 Lysosome vesicle biogenesis 14 32 1.8768002387881502 0.05856168488815612 0.2110913147232846 O14964,O43747,P05067,P09496,P09497,P11142,P15586,P20645,P50570,P51809,Q00610,Q10567,Q8NBS9,Q9BXS5 N glycan trimming in the er and calnexin calreticulin cycle 14 32 1.8768002387881502 0.05856168488815612 0.2110913147232846 P14314,P27797,P27824,P30101,P54727,P55072,P62191,Q04323,Q13724,Q14165,Q14697,Q9BUN8,Q9NYU2,Q9UBV2 Protein ubiquitination 23 58 1.5867487850647164 0.05928894389789291 0.21322262392636715 A0AVT1,O75150,O75381,P04439,P12004,P22314,P45974,P50542,P55072,P61086,P61088,P68036,P78527,Q14527,Q16763,Q5VTR2,Q6P1J9,Q6PD62,Q8N7H5,Q93008,Q93009,Q9BUN8,Q9GZS3 Mitochondrial biogenesis 32 85 1.458643549209587 0.060733639986091464 0.21791841532766912 O00411,O75431,O75947,O75964,P00367,P04179,P06576,P24539,P25705,P36542,P38646,P48047,P48735,P51610,P54619,P56134,P56385,Q00059,Q04837,Q13505,Q15648,Q16539,Q16891,Q5XKP0,Q6UXV4,Q86X55,Q8WVM0,Q96RR1,Q9BUR5,Q9NVH1,Q9NX63,Q9Y512 Rhov gtpase cycle 15 35 1.8098757138058448 0.06127282550488851 0.21935111961567394 O43396,P06753,P46940,P60953,P67936,Q00610,Q01082,Q03001,Q13177,Q13813,Q16512,Q8TAA9,Q93008,Q96KM6,Q9NNW5 Mitophagy 11 24 2.041158103888731 0.06420927719330607 0.22881851508887258 O94826,O95140,O96008,P19784,P21796,P67870,Q15388,Q8IWA4,Q8N4H5,Q96HS1,Q9NS69 Maturation of sars cov 2 spike protein 11 24 2.041158103888731 0.06420927719330607 0.22881851508887258 P04843,P04844,P14314,P27824,P39656,P46977,P61803,Q13724,Q14697,Q16706,Q9H0U3 Suppression of apoptosis 4 6 4.820615796519411 0.06533361349859668 0.2302092268894373 P23246,P27361,P28482,P49840 Alpha oxidation of phytanate 4 6 4.820615796519411 0.06533361349859668 0.2302092268894373 O43808,P51648,Q9BY49,Q9UJ83 Sensing of dna double strand breaks 4 6 4.820615796519411 0.06533361349859668 0.2302092268894373 O60934,P49959,P52292,Q92878 Keratan sulfate degradation 4 6 4.820615796519411 0.06533361349859668 0.2302092268894373 P06865,P07686,P15586,P16278 Stat3 nuclear events downstream of alk signaling 4 6 4.820615796519411 0.06533361349859668 0.2302092268894373 P40763,Q13547,Q92769,Q96ST3 Activation of bad and translocation to mitochondria 8 16 2.4115281501340484 0.06602295645674532 0.23211658234120328 P27348,P31751,P31946,P61981,P62258,P63104,Q04917,Q9Y3B8 Kinesins 19 47 1.63788381144587 0.06819768857191774 0.23922589637755484 O00139,O95235,O95239,P04350,P33176,P52732,P68371,Q02241,Q07866,Q12756,Q13885,Q14807,Q99661,Q9BUF5,Q9BVA1,Q9BW19,Q9H0B6,Q9H0H5,Q9Y496 Ercc6 csb and ehmt2 g9a positively regulate rrna expression 12 27 1.9299328859060403 0.06861696853304769 0.24015938986566693 O94776,O95983,P16104,P62805,Q13185,Q13330,Q13547,Q14839,Q86YP4,Q8WXI9,Q92769,Q96KQ7 Signaling by braf and raf1 fusions 21 53 1.584188825311343 0.06999802186754242 0.24444743494054902 O00203,O15164,O43252,P02545,P18206,P27361,P28482,P30086,P31946,P41240,P46940,P51114,Q02750,Q13555,Q53H12,Q6WCQ1,Q7KZF4,Q7Z2W4,Q96PU8,Q9NRY5,Q9Y490 Eph ephrin signaling 30 80 1.4491559756921 0.07103054260140017 0.2453213453722367 O00560,O15143,O15144,O15145,O75116,O94973,O95782,P09496,P09497,P23528,P35579,P35580,P53680,P59998,P60660,P60953,P61158,P61160,P61586,P63000,P63010,Q00610,Q13177,Q13464,Q15375,Q16512,Q7Z406,Q92542,Q92747,Q96CW1 Trafficking of glur2 containing ampa receptors 6 11 2.8931011386470193 0.07093005123470365 0.2453213453722367 O94973,O95782,P46459,P53680,P63010,Q96CW1 Rac3 gtpase cycle 31 83 1.4399501208011847 0.07072269461999198 0.2453213453722367 O00161,O15173,O15498,P02786,P05556,P42166,P42167,P49257,P50402,P51149,P60953,Q01968,Q07960,Q13112,Q13177,Q14126,Q14739,Q15758,Q16512,Q5T2T1,Q68EM7,Q6IAA8,Q7L576,Q8TAA9,Q96AC1,Q9BSJ8,Q9H0H5,Q9NSV4,Q9UQB8,Q9Y2A7,Q9Y2U8 Synaptic adhesion like molecules 6 11 2.8931011386470193 0.07093005123470365 0.2453213453722367 O75955,O95197,P10586,P41440,Q14254,Q15334 Met activates rap1 and rac1 6 11 2.8931011386470193 0.07093005123470365 0.2453213453722367 P46108,P46109,P62993,P63000,Q96N67,Q9NWH9 Sphingolipid metabolism 24 62 1.5248971485317067 0.07135285891250662 0.2458929291754074 A0FGR8,O15269,O15270,O43681,O95292,O95470,P04062,P06280,P06865,P07602,P07686,P10619,P16278,P17900,P22059,P27544,P51648,Q06136,Q13510,Q96G23,Q9BSJ8,Q9NXE4,Q9NZJ7,Q9P0L0 Class i peroxisomal membrane protein import 9 19 2.17049949715052 0.07403714366614124 0.25458386243094183 O43808,O75381,P28288,P40855,P51648,Q5T8D3,Q8NBU5,Q8TB36,Q9NR77 Glycosphingolipid metabolism 14 33 1.7777738503410978 0.07511719991571303 0.25773253712874844 A0FGR8,O43681,P04062,P06280,P06865,P07602,P07686,P10619,P16278,P17900,Q13510,Q9BSJ8,Q9NXE4,Q9NZJ7 Trafficking of myristoylated proteins to the cilium 3 4 7.229508196721311 0.07879177424190878 0.26683693738944486 A6NIH7,O75695,P36405 Mecp2 regulates transcription of neuronal ligands 3 4 7.229508196721311 0.07879177424190878 0.26683693738944486 P51608,Q13547,Q96ST3 Phenylalanine metabolism 3 4 7.229508196721311 0.07879177424190878 0.26683693738944486 P09417,P61457,Q7L266 Apobec3g mediated resistance to hiv 1 infection 3 4 7.229508196721311 0.07879177424190878 0.26683693738944486 O75475,O75531,P17096 Arachidonate production from dag 3 4 7.229508196721311 0.07879177424190878 0.26683693738944486 Q8N2K0,Q8NCG7,Q9BV23 Glucuronidation 3 4 7.229508196721311 0.07879177424190878 0.26683693738944486 O60701,Q16851,Q9NUJ1 Rhou gtpase cycle 16 39 1.6785881252921926 0.07935247709534232 0.2681566467359844 O14964,O43396,P46940,P60953,P62993,Q00610,Q01082,Q03001,Q13177,Q13813,Q16512,Q8TAA9,Q92783,Q93008,Q9NNW5,Q9UM54 Fgfr1 mutant receptor activation 10 22 2.009836798569193 0.08031165343941797 0.2702332029892862 O15164,O94905,O95429,O95684,P40763,P42224,P62993,Q16630,Q92614,Q9UBW7 Vegfr2 mediated vascular permeability 10 22 2.009836798569193 0.08031165343941797 0.2702332029892862 O60716,P07900,P14923,P31751,P35221,P35222,P42345,P63000,Q13177,Q16512 Activation of gene expression by srebf srebp 17 42 1.6409142857142858 0.080843349473322 0.2708597691755745 O00763,O00767,O75845,P14324,P37268,P48449,P49327,Q01581,Q13085,Q13907,Q14534,Q15126,Q15648,Q16850,Q86X55,Q9HCL2,Q9UBM7 Rhof gtpase cycle 17 42 1.6409142857142858 0.080843349473322 0.2708597691755745 O00161,O60610,P12814,P20700,P42166,P42167,P47756,P51149,P80723,Q02952,Q07960,Q5JTV8,Q8TAA9,Q9BSJ8,Q9NSV4,Q9UEY8,Q9Y6M7 B wich complex positively regulates rrna expression 18 45 1.6088321004259134 0.0820025666264636 0.27415783469146043 O00159,O15160,O15446,O60264,O75533,O95602,P16104,P19388,P35659,P49841,P62805,P62875,Q9BQG0,Q9GZS1,Q9H9Y6,Q9NR30,Q9NY93,Q9UIG0 Peroxisomal protein import 20 51 1.5571137064212217 0.08351821275136845 0.27863097360456535 O00116,O14734,O15228,O15254,O75381,O75521,O75874,P09110,P14735,P22307,P34913,P35914,P50542,P51659,Q13011,Q15067,Q93008,Q9BY49,Q9UJ83,Q9Y2Q3 Purine catabolism 7 14 2.4110552763819095 0.08399602505343567 0.2789347045735225 O43598,P00491,P36639,P49902,Q9BW91,Q9BY32,Q9UKK9 Oncogenic mapk signaling 25 66 1.4720872689010005 0.08414293065259959 0.2789347045735225 O00203,O15164,O43252,P02545,P18206,P27361,P28482,P30086,P31946,P35232,P41240,P46940,P51114,P62140,Q02750,Q13555,Q53H12,Q6WCQ1,Q7KZF4,Q7Z2W4,Q96PU8,Q99956,Q9NRY5,Q9UQ13,Q9Y490 Glutamate and glutamine metabolism 7 14 2.4110552763819095 0.08399602505343567 0.2789347045735225 O94925,P00367,P00505,P04181,P32322,P54886,Q96C36 Tyrosine catabolism 2 2 inf 0.08609163292910883 0.2841930114375635 O43708,P16930 Hdl clearance 2 2 inf 0.08609163292910883 0.2841930114375635 Q00341,Q8WTV0 Hemostasis 118 361 1.17614428779665 0.08767963732896086 0.2888270406130476 O00139,O00186,O43707,O43852,O60341,O75083,O94919,O95140,O95235,O95239,P04075,P04350,P04637,P04899,P05026,P05067,P05556,P07355,P07602,P07737,P08195,P08754,P10644,P12814,P13473,P13861,P14174,P16615,P17612,P18031,P18206,P19174,P20020,P20339,P21333,P23528,P24941,P27144,P27361,P28482,P30153,P30154,P30626,P33176,P35237,P35613,P37802,P41240,P42785,P45973,P46108,P47755,P47756,P52732,P52907,P53985,P54709,P55145,P60903,P60953,P61586,P62993,P63000,P63096,P63104,P68371,P78310,P84095,Q00535,Q01518,Q02241,Q06124,Q07021,Q07866,Q08380,Q08722,Q12756,Q12846,Q13547,Q13685,Q13885,Q14344,Q14738,Q14807,Q16539,Q6UXV4,Q8IWA4,Q8N2K0,Q8NBF2,Q8NBX0,Q8NCG7,Q92520,Q92667,Q92769,Q92896,Q96JJ7,Q96N67,Q96ST3,Q99661,Q9BUF5,Q9BV23,Q9BVA1,Q9BW19,Q9BWS9,Q9H0B6,Q9H0H5,Q9H4M9,Q9NTK5,Q9NUQ9,Q9NZJ7,Q9UBI6,Q9UHQ9,Q9UKL0,Q9UNF1,Q9Y490,Q9Y496,Q9Y624,Q9Y6I9 Gap junction trafficking and regulation 12 28 1.8090604026845638 0.08908962400272766 0.292243787523592 P04350,P09496,P09497,P50570,P68371,Q00610,Q07157,Q13885,Q96CW1,Q9BUF5,Q9BVA1,Q9UM54 Smooth muscle contraction 12 28 1.8090604026845638 0.08908962400272766 0.292243787523592 P04083,P06753,P07355,P08133,P09493,P18206,P60660,P67936,Q05682,Q13177,Q16512,Q9Y490 Hyaluronan metabolism 5 9 3.013056578506863 0.09088706524472653 0.29628049543395263 O75330,P06865,P07686,P08236,Q9UHD1 Beta oxidation of very long chain fatty acids 5 9 3.013056578506863 0.09088706524472653 0.29628049543395263 O14734,O75521,P09110,P51659,Q15067 Wnt ligand biogenesis and trafficking 5 9 3.013056578506863 0.09088706524472653 0.29628049543395263 O60493,O75436,Q96QK1,Q9UBQ0,Q9Y3A6 Pink1 prkn mediated mitophagy 8 17 2.143282692880548 0.09359901788305844 0.30448809137061333 O94826,O95140,O96008,P21796,Q15388,Q8IWA4,Q8N4H5,Q9NS69 Transcriptional regulation by tp53 109 333 1.1781192706010604 0.09443394013609938 0.3065681534853081 A5YKK6,O00267,O00483,O14744,O14965,O15514,O43819,O60934,O75880,O94776,O94925,O95983,O96017,P00390,P00403,P04637,P06493,P06744,P06748,P09669,P10606,P11413,P12004,P13073,P14635,P15927,P15954,P18074,P18615,P19387,P19388,P19447,P19784,P20674,P23193,P24928,P24941,P27348,P27694,P30044,P30153,P30154,P30876,P31751,P31946,P32119,P35244,P35249,P35250,P35269,P38398,P40937,P40938,P42345,P42704,P43246,P49327,P49959,P50750,P51530,P54132,P54619,P61981,P62258,P62487,P62875,P63104,P67870,Q00535,Q04917,Q08945,Q13526,Q13547,Q14241,Q14676,Q14839,Q15369,Q15370,Q16539,Q16881,Q6IAA8,Q86X55,Q86YP4,Q8IXH7,Q8TBX8,Q8WX92,Q8WXI9,Q92600,Q92696,Q92769,Q92804,Q92878,Q93009,Q96KQ7,Q99873,Q9BXW9,Q9C0C2,Q9H3P2,Q9HCE1,Q9NQ88,Q9NVI1,Q9NYV4,Q9UIV1,Q9ULW0,Q9UQ84,Q9Y2Q5,Q9Y3B8,Q9Y3T9,Q9Y5B9 E3 ubiquitin ligases ubiquitinate target proteins 16 40 1.6084229390681004 0.09752865660708408 0.31596060652873525 O75150,O75381,P04439,P12004,P50542,P55072,P61088,P68036,P78527,Q14527,Q5VTR2,Q6P1J9,Q6PD62,Q8N7H5,Q9BUN8,Q9GZS3 Negative epigenetic regulation of rrna expression 23 61 1.4608675612912376 0.0991163071577092 0.32008822378861657 O00422,O15160,O15446,O43159,O60264,O95602,P16104,P17480,P18074,P19388,P19447,P26358,P62805,P62875,Q13547,Q15393,Q92769,Q96EB6,Q96ST3,Q9GZS1,Q9H9Y6,Q9UHR5,Q9UIF9 Rhoj gtpase cycle 21 55 1.4905854634011126 0.09961929413829394 0.32008822378861657 O00161,O75323,P02786,P14923,P27105,P42166,P42167,P51149,P60953,Q01968,Q07960,Q13112,Q13177,Q14160,Q15758,Q16512,Q5T2T1,Q6IAA8,Q8TAA9,Q9NSV4,Q9Y6M7 Rna polymerase i transcription initiation 19 49 1.528265500616661 0.09949021390888278 0.32008822378861657 O15160,O15446,O94776,O95602,O95983,P17480,P18074,P19388,P19447,P62875,Q13330,Q13547,Q14839,Q86YP4,Q8WXI9,Q92769,Q96KQ7,Q9GZS1,Q9H9Y6 Dna double strand break response 19 49 1.528265500616661 0.09949021390888278 0.32008822378861657 O60264,O60934,O96017,O96028,P04637,P16104,P38398,P49959,P52292,P53041,P61088,P62805,Q04323,Q12888,Q14676,Q92878,Q9NWV8,Q9NXR7,Q9UIG0 Trafficking of ampa receptors 9 20 1.9729070795111694 0.10072645133853766 0.32036323671161676 O94973,O95782,P46459,P53680,P63010,Q13555,Q15334,Q96CW1,Q9UM54 Conversion from apc c cdc20 to apc c cdh1 in late anaphase 9 20 1.9729070795111694 0.10072645133853766 0.32036323671161676 P30260,Q16763,Q96DE5,Q9H1A4,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6 Glycogen metabolism 9 20 1.9729070795111694 0.10072645133853766 0.32036323671161676 P06737,P10253,P11216,P13807,P35573,P36871,P46976,Q16851,Q96G03 Antigen processing ubiquitination proteasome degradation 83 250 1.2022795248279652 0.10033214446908323 0.32036323671161676 A0AVT1,O00231,O00232,O00487,O14818,O43242,O75832,O94822,O94874,O95376,P17980,P19474,P20618,P22314,P25786,P25787,P25788,P25789,P28066,P28070,P28072,P28074,P29144,P30260,P35998,P43686,P48556,P49720,P49721,P51665,P52888,P55036,P55786,P60900,P61081,P61086,P61088,P61289,P62191,P62195,P62333,P63208,P68036,Q05086,Q06323,Q13200,Q13309,Q13616,Q13617,Q13618,Q13867,Q14139,Q14669,Q14997,Q15008,Q15369,Q15370,Q15386,Q16763,Q5T447,Q5T4S7,Q7Z6E9,Q7Z6Z7,Q8TBC4,Q92530,Q92990,Q93034,Q96J02,Q99436,Q99460,Q9C0C9,Q9H1A4,Q9UIQ6,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6,Q9UL46,Q9ULT8,Q9UNE7,Q9UNM6,Q9Y4B6 Darpp 32 events 9 20 1.9729070795111694 0.10072645133853766 0.32036323671161676 P10644,P13861,P17612,P30153,P30154,P62136,Q00535,Q08209,Q14738 Cilium assembly 62 183 1.2386709164245622 0.10176956727457116 0.3230256710253595 A0AVF1,A6NIH7,O00471,O43805,O43924,O60645,O75695,O75935,O94927,O95684,P04350,P06493,P07437,P07900,P17612,P17987,P18085,P30153,P36405,P41208,P43034,P48643,P49368,P50990,P50991,P53350,P61006,P61163,P61981,P62258,P63167,P68371,P78371,Q10713,Q13409,Q13561,Q13885,Q14008,Q14203,Q14204,Q15019,Q15154,Q15691,Q68CZ6,Q7Z460,Q7Z4H7,Q8IYI6,Q8NCM8,Q8TAG9,Q92538,Q92973,Q96A65,Q96CS2,Q96FJ2,Q96KP1,Q9BUF5,Q9BVA1,Q9BW83,Q9H6D7,Q9NQ48,Q9UPT5,Q9Y496 Condensation of prophase chromosomes 10 23 1.8549760099055874 0.1060423719973359 0.3352307243786748 O95347,P06493,P14635,P16104,P42695,P53350,P62805,Q01105,Q86XI2,Q9NTJ3 Mtorc1 mediated signalling 10 23 1.8549760099055874 0.1060423719973359 0.3352307243786748 P06730,P23588,P31946,P42345,P62753,P62942,Q04637,Q6IAA8,Q96B36,Q9Y2Q5 Methylation 6 12 2.4105827193569995 0.10760968518591266 0.3367903919591039 P21964,P23526,P31153,P78417,Q99707,Q9NZL9 Gap junction degradation 6 12 2.4105827193569995 0.10760968518591266 0.3367903919591039 P09496,P09497,P50570,Q00610,Q96CW1,Q9UM54 Alk mutants bind tkis 6 12 2.4105827193569995 0.10760968518591266 0.3367903919591039 O43815,P06748,P10644,Q00610,Q9HC35,Q9NR09 Heme biosynthesis 6 12 2.4105827193569995 0.10760968518591266 0.3367903919591039 P06132,P08397,P22830,P36551,P50336,Q7KZN9 Prolonged erk activation events 6 12 2.4105827193569995 0.10760968518591266 0.3367903919591039 P27361,P28482,P31946,P46108,P46109,Q02750 Rho gtpases activate iqgaps 11 26 1.7685116851168512 0.11000232189066549 0.3421337055739683 P04350,P35221,P35222,P46940,P60953,P63000,P68371,Q13576,Q13885,Q9BUF5,Q9BVA1 Autophagy 45 130 1.2788878021517396 0.11018974573651402 0.3421337055739683 O43237,O60664,O94826,O95140,O96008,P04350,P07900,P08238,P08670,P11142,P13473,P19784,P21796,P42345,P50542,P54619,P55072,P60520,P61088,P63167,P67870,P68371,Q13409,Q13885,Q14204,Q15388,Q6IAA8,Q8IWA4,Q8N4H5,Q8WUX9,Q96FJ2,Q96HS1,Q99497,Q99570,Q99816,Q9BUF5,Q9BVA1,Q9H9H4,Q9NS69,Q9NT62,Q9UQN3,Q9Y2Q5,Q9Y4P1,Q9Y4P8,Q9Y6G9 Ripk1 mediated regulated necrosis 11 26 1.7685116851168512 0.11000232189066549 0.3421337055739683 O00560,O15294,O75955,P07900,P41440,P49327,Q13546,Q14254,Q16543,Q8WUM4,Q9UNE7 Signaling by retinoic acid 11 26 1.7685116851168512 0.11000232189066549 0.3421337055739683 O00330,P08559,P09622,P10515,P11177,P50416,Q15118,Q15120,Q8NBN7,Q8TC12,Q9HBH5 Sars cov 2 infection 23 62 1.4232107849487439 0.11548962278659436 0.3578808864216995 P04843,P04844,P14314,P17844,P27824,P39656,P46977,P48729,P49840,P49841,P55072,P61803,P78362,Q10472,Q13724,Q14697,Q16706,Q8WUX9,Q96SB4,Q99570,Q99873,Q9H0U3,Q9UQN3 Hdr through single strand annealing ssa 14 35 1.6080143272890084 0.11653376332931295 0.3604042226831612 O60934,P15927,P27694,P35244,P35249,P35250,P38398,P40937,P40938,P49959,P51530,P54132,Q92878,Q9UQ84 Activation of nima kinases nek9 nek6 nek7 4 7 3.213297634984382 0.11762512871227465 0.36093190180204826 P06493,P14635,P53350,Q8TD19 Rsk activation 4 7 3.213297634984382 0.11762512871227465 0.36093190180204826 P27361,P28482,P51812,Q15418 Dna damage telomere stress induced senescence 15 38 1.5731477559842852 0.11751489260349446 0.36093190180204826 O60934,P04637,P07305,P10412,P16104,P16402,P16403,P17096,P20700,P24941,P49959,P62805,Q92878,Q96L91,Q9NYB0 Beta oxidation of pristanoyl coa 4 7 3.213297634984382 0.11762512871227465 0.36093190180204826 O14734,O15254,P22307,P51659 Nonhomologous end joining nhej 16 41 1.5438709677419356 0.11808871472557006 0.36164668884705836 O60934,O96028,P12956,P13010,P16104,P38398,P49959,P61088,P62805,P78527,Q12888,Q14676,Q5UIP0,Q92878,Q9NWV8,Q9NXR7 Inlb mediated entry of listeria monocytogenes into host cell 7 15 2.1093802345058625 0.11892326524849411 0.36349255343009507 O14964,P22681,P42566,P62993,Q92783,Q99961,Q9NWH9 Rhoa gtpase cycle 46 134 1.2626365487872617 0.1198877157759963 0.3657275064917552 O00161,O15173,O15498,O60610,O75116,O75955,O95292,P02786,P14923,P27105,P28288,P30519,P41440,P42166,P42167,P46940,P49257,P51572,P52565,P61586,P63167,Q07021,Q07960,Q13190,Q13464,Q14254,Q14739,Q15904,Q16512,Q16513,Q5T8D3,Q86UP2,Q8NBN3,Q8TAA9,Q8WVM8,Q92888,Q92974,Q96CS3,Q96HY6,Q9H0H5,Q9H2G2,Q9NQW6,Q9NRG9,Q9NSV4,Q9P0I2,Q9UDY2 Signaling by cytosolic fgfr1 fusion mutants 8 18 1.928686327077748 0.12673553378389676 0.3843739206443909 O15164,O95684,P40763,P42224,P62993,Q16630,Q92614,Q9UBW7 Arachidonic acid metabolism 8 18 1.928686327077748 0.12673553378389676 0.3843739206443909 P09960,P16152,P34913,Q14914,Q15165,Q15185,Q8N8N7,Q9H7Z7 Tp53 regulates transcription of genes involved in g2 cell cycle arrest 8 18 1.928686327077748 0.12673553378389676 0.3843739206443909 O14965,P04637,P06493,P12004,P14635,Q86X55,Q99873,Q9Y3B8 Telomere extension by telomerase 9 21 1.8082467314783774 0.13216909253637654 0.39854064826353547 O00743,O60832,P24941,Q5H9R7,Q9NX24,Q9NY12,Q9NYB0,Q9Y230,Q9Y265 Insulin processing 9 21 1.8082467314783774 0.13216909253637654 0.39854064826353547 O00471,O60645,P33176,Q8IYI6,Q8TAG9,Q96A65,Q96HE7,Q96KP1,Q9UPT5 Listeria monocytogenes entry into host cells 9 21 1.8082467314783774 0.13216909253637654 0.39854064826353547 O14964,O60716,P22681,P35222,P42566,P62993,Q92783,Q99961,Q9NWH9 Rna polymerase i transcription 23 63 1.387436847423375 0.13343297684946662 0.4015794773511778 O15160,O15446,O94776,O95602,O95983,P16104,P17480,P18074,P19388,P19447,P27361,P62805,P62875,Q13185,Q13330,Q13547,Q14839,Q86YP4,Q8WXI9,Q92769,Q96KQ7,Q9GZS1,Q9H9Y6 Detoxification of reactive oxygen species 10 24 1.7222381910510682 0.1359231540052867 0.40750957070801064 P00390,P04179,P07237,P30041,P30044,P30048,P32119,Q16881,Q8TED1,Q96HE7 Cyclin a b1 b2 associated events during g2 m transition 10 24 1.7222381910510682 0.1359231540052867 0.40750957070801064 O14980,P06493,P14635,P24941,P30153,P30154,P53350,P63151,Q99640,Q9Y570 Senescence associated secretory phenotype sasp 20 54 1.4191275433457367 0.13741997975500375 0.4112109317859654 P11802,P16104,P24941,P27361,P28482,P30260,P40763,P51812,P62805,Q00534,Q15418,Q16763,Q96DE5,Q96KQ7,Q9H1A4,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6 Rrna processing in the mitochondrion 5 10 2.410110478741212 0.13914968269149575 0.4132323910232298 O15091,Q7L0Y3,Q8WVM0,Q99714,Q9BQ52 Metabolism of nitric oxide nos3 activation and regulation 5 10 2.410110478741212 0.13914968269149575 0.4132323910232298 O75608,P07900,P35270,P50570,Q9Y314 Cooperation of pdcl phlp1 and tric cct in g protein beta folding 11 27 1.6577490774907748 0.13845475232296928 0.4132323910232298 P17987,P19784,P40227,P48643,P49368,P50990,P50991,P67870,P78371,Q99832,Q9UBI6 E2f enabled inhibition of pre replication complex formation 5 10 2.410110478741212 0.13914968269149575 0.4132323910232298 O43913,P06493,P14635,Q9UBD5,Q9Y619 Regulation of tp53 activity through phosphorylation 29 82 1.3205573137882947 0.1404169106471797 0.416207402447595 O14965,O60934,O96017,P04637,P15927,P19784,P24941,P27694,P35244,P35249,P35250,P38398,P40937,P40938,P49959,P51530,P54132,P54619,P67870,Q00535,Q08945,Q13526,Q16539,Q92804,Q92878,Q9ULW0,Q9UQ84,Q9Y3T9,Q9Y5B9 Regulation of localization of foxo transcription factors 6 13 2.0659267055784136 0.15205250953674665 0.44117883795271623 P27348,P31751,P31946,P61981,P63104,Q9Y3B8 Synthesis of gdp mannose 3 5 3.614252258280361 0.15446886609441404 0.44117883795271623 P34949,Q96IJ6,Q9Y5P6 Sema3a pak dependent axon repulsion 6 13 2.0659267055784136 0.15205250953674665 0.44117883795271623 P07900,P08238,P23528,P63000,Q13177,Q16512 Signaling by receptor tyrosine kinases 110 344 1.1368826254322437 0.15150293186432678 0.44117883795271623 O14654,O14964,O15514,O43865,O60610,O60716,O75116,O94973,O95782,P04792,P05556,P07900,P09496,P09651,P11233,P14923,P16949,P17612,P18031,P19174,P19387,P19388,P20338,P21281,P21283,P22681,P24928,P26599,P27361,P28482,P30153,P30154,P30876,P31483,P31751,P31943,P31946,P35221,P35222,P35269,P36543,P38606,P40763,P41240,P42224,P42345,P42566,P46108,P46109,P50570,P51452,P51812,P52272,P52597,P53680,P60953,P61201,P61421,P61586,P62330,P62487,P62875,P62993,P63000,P63010,Q00535,Q00610,Q01085,Q02750,Q06124,Q09161,Q13043,Q13177,Q13464,Q13547,Q13685,Q14738,Q14839,Q15334,Q15418,Q15904,Q16512,Q16539,Q16543,Q7L576,Q8IV63,Q8WX92,Q92542,Q92769,Q92783,Q93034,Q93050,Q96CW1,Q96F07,Q96J02,Q96JJ3,Q96N67,Q96P70,Q96S59,Q96ST3,Q99570,Q99961,Q9NWH9,Q9UBC2,Q9UI12,Q9UNE7,Q9UQB8,Q9Y2A7,Q9Y487,Q9Y5K8 G2 m dna replication checkpoint 3 5 3.614252258280361 0.15446886609441404 0.44117883795271623 P06493,P14635,Q99640 P75ntr regulates axonogenesis 3 5 3.614252258280361 0.15446886609441404 0.44117883795271623 P52565,P61586,Q9NQC3 Glycogen breakdown glycogenolysis 6 13 2.0659267055784136 0.15205250953674665 0.44117883795271623 P06737,P10253,P11216,P35573,P46976,Q96G03 Propionyl coa catabolism 3 5 3.614252258280361 0.15446886609441404 0.44117883795271623 P05165,P05166,P22033 Ethanol oxidation 3 5 3.614252258280361 0.15446886609441404 0.44117883795271623 P05091,P11766,P30837 Rho gtpases activate nadph oxidases 6 13 2.0659267055784136 0.15205250953674665 0.44117883795271623 P27361,P28482,P63000,Q13526,Q16539,Q99570 Formation of xylulose 5 phosphate 3 5 3.614252258280361 0.15446886609441404 0.44117883795271623 P14550,Q00796,Q7Z4W1 Beta oxidation of butanoyl coa to acetyl coa 3 5 3.614252258280361 0.15446886609441404 0.44117883795271623 P30084,P40939,Q16836 Inhibition of replication initiation of damaged dna by rb1 e2f1 6 13 2.0659267055784136 0.15205250953674665 0.44117883795271623 P09884,P30153,P30154,P49642,P49643,Q14181 Maturation of sars cov 2 nucleoprotein 6 13 2.0659267055784136 0.15205250953674665 0.44117883795271623 P48729,P49840,P49841,P78362,Q96SB4,Q99873 Met activates ptpn11 3 5 3.614252258280361 0.15446886609441404 0.44117883795271623 P62993,Q06124,Q9NWH9 Synthesis secretion and deacylation of ghrelin 3 5 3.614252258280361 0.15446886609441404 0.44117883795271623 P61009,P67812,Q15005 Diseases of mismatch repair mmr 3 5 3.614252258280361 0.15446886609441404 0.44117883795271623 P20585,P43246,P52701 Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation 3 5 3.614252258280361 0.15446886609441404 0.44117883795271623 P06748,P10809,P46087 Cytosolic iron sulfur cluster assembly 6 13 2.0659267055784136 0.15205250953674665 0.44117883795271623 O75027,P18074,P28340,Q6FI81,Q96T76,Q9Y5Y2 Synthesis of pips at the er membrane 3 5 3.614252258280361 0.15446886609441404 0.44117883795271623 P42356,Q13614,Q9NTJ5 Diseases associated with glycosylation precursor biosynthesis 7 16 1.8747440908244928 0.16006794986564526 0.4538635540494245 O60762,P10619,P16278,P34949,P36871,P51570,Q06210 Protein methylation 7 16 1.8747440908244928 0.16006794986564526 0.4538635540494245 O60678,O60870,P11142,P13639,P15880,P38117,P55072 Cell extracellular matrix interactions 7 16 1.8747440908244928 0.16006794986564526 0.4538635540494245 P05556,P12814,P21333,Q13418,Q14315,Q15404,Q96AC1 Chaperone mediated autophagy 7 16 1.8747440908244928 0.16006794986564526 0.4538635540494245 O60664,P07900,P08238,P08670,P11142,P13473,Q99497 Nucleotide catabolism 9 22 1.6689187446813998 0.16807039652540529 0.47569382987695935 O43598,P00491,P36639,P49902,Q9BW91,Q9BY32,Q9H0P0,Q9UKK9,Q9Y3Z3 Signaling by fgfr2 in disease 11 28 1.5600173648795312 0.17039689417618217 0.48054375911556413 O15514,P19174,P19387,P19388,P24928,P30876,P35269,P62487,P62875,P62993,Q09161 Meiotic recombination 12 31 1.5227834687389614 0.17037462799243364 0.48054375911556413 O60934,P11802,P15927,P16104,P24941,P27694,P35244,P38398,P49959,P54132,P62805,Q92878 Rhoq gtpase cycle 21 59 1.3329376959733565 0.17952481770552808 0.5053768656414148 O00161,P02786,P14923,P27105,P46940,P51149,P60953,P63167,Q07960,Q13112,Q13177,Q14160,Q15758,Q16512,Q5T2T1,Q68EM7,Q6IAA8,Q8TAA9,Q9HD26,Q9NSV4,Q9Y6M7 Prevention of phagosomal lysosomal fusion 4 8 2.4096385542168677 0.18229924803912137 0.507717976776807 O14964,P20339,P51149,Q9H267 Mapk3 erk1 activation 4 8 2.4096385542168677 0.18229924803912137 0.507717976776807 P06493,P27361,Q02750,Q06124 Interleukin 6 signaling 4 8 2.4096385542168677 0.18229924803912137 0.507717976776807 P22681,P40763,P42224,Q06124 Synthesis of udp n acetyl glucosamine 4 8 2.4096385542168677 0.18229924803912137 0.507717976776807 O95394,Q06210,Q16222,Q9UJ70 Synthesis of prostaglandins pg and thromboxanes tx 4 8 2.4096385542168677 0.18229924803912137 0.507717976776807 P16152,Q15185,Q8N8N7,Q9H7Z7 Dna damage reversal 4 8 2.4096385542168677 0.18229924803912137 0.507717976776807 Q6P6C2,Q8N3C0,Q9C0B1,Q9H1I8 Glycogen synthesis 5 11 2.008146412230778 0.19599937557275937 0.5449060654221396 P13807,P36871,P46976,Q16851,Q96G03 Hdr through homologous recombination hrr 23 66 1.2900984592729523 0.19636604690817636 0.544959223985877 O60934,P12004,P15927,P27694,P28340,P35244,P35249,P35250,P35251,P38398,P40937,P40938,P41440,P49005,P49959,P51530,P54132,Q07864,Q92878,Q9NR33,Q9NRF9,Q9UQ84,Q9Y2S7 Ptk6 regulates proteins involved in rna processing 2 3 4.818060200668897 0.20777186122599708 0.5592939235956129 P23246,Q07666 Spry regulation of fgf signaling 6 14 1.8074346952444742 0.2030948729002972 0.5592939235956129 P22681,P27361,P28482,P30153,P62993,Q06124 Binding and uptake of ligands by scavenger receptors 7 17 1.6870351758793969 0.20659620225092035 0.5592939235956129 P07900,P14625,P27797,Q5KU26,Q8WTV0,Q92598,Q9Y4L1 Peptide ligand binding receptors 7 17 1.6870351758793969 0.20659620225092035 0.5592939235956129 P04083,P05067,P07602,P42892,Q9BYT8,Q9NRV9,Q9NZJ7 Activation of bh3 only proteins 11 29 1.4731447314473145 0.20551747321849864 0.5592939235956129 P04637,P27348,P31751,P31946,P61981,P62258,P63104,P63167,Q04917,Q96FJ2,Q9Y3B8 Nephrin family interactions 7 17 1.6870351758793969 0.20659620225092035 0.5592939235956129 O14936,O43707,P12814,P46940,Q01082,Q13813,Q9Y5K6 Signaling by fgfr1 in disease 11 29 1.4731447314473145 0.20551747321849864 0.5592939235956129 O15164,O94905,O95429,O95684,P19174,P40763,P42224,P62993,Q16630,Q92614,Q9UBW7 Neurotransmitter clearance 2 3 4.818060200668897 0.20777186122599708 0.5592939235956129 P05091,P21964 Negative regulation of met activity 8 20 1.606791778373548 0.20795175858178722 0.5592939235956129 O14964,P18031,P22681,P42566,P62993,Q92783,Q99961,Q9NWH9 Sema4d in semaphorin signaling 9 23 1.549494755998276 0.20794555514473378 0.5592939235956129 O75116,P35579,P35580,P60660,P61586,P63000,Q13464,Q7Z406,Q9NWH9 Synthesis of very long chain fatty acyl coas 7 17 1.6870351758793969 0.20659620225092035 0.5592939235956129 O60488,O95573,P33121,Q4G176,Q53GQ0,Q9NZ01,Q9P035 Organic anion transporters 2 3 4.818060200668897 0.20777186122599708 0.5592939235956129 Q9H936,Q9UBX3 Anchoring of the basal body to the plasma membrane 32 95 1.2253968253968255 0.20468807461090244 0.5592939235956129 O43805,O75935,O94927,O95684,P04350,P06493,P07437,P07900,P17612,P30153,P41208,P43034,P53350,P61006,P61163,P61981,P62258,P63167,P68371,Q13409,Q13561,Q14008,Q14203,Q14204,Q15019,Q15154,Q15691,Q68CZ6,Q7Z460,Q7Z4H7,Q96CS2,Q9H6D7 Sealing of the nuclear envelope ne by escrt iii 10 26 1.506539235412475 0.2070382767879614 0.5592939235956129 P04350,P53990,P68371,Q13885,Q8NC56,Q8WUX9,Q9BUF5,Q9BVA1,Q9UN37,Q9UQN3 Signal transduction by l1 8 20 1.606791778373548 0.20795175858178722 0.5592939235956129 P05556,P19784,P27361,P28482,P63000,P67870,Q02750,Q16512 Diseases of carbohydrate metabolism 9 23 1.549494755998276 0.20794555514473378 0.5592939235956129 P08236,P10253,P13807,P15586,P16278,P37837,P46976,P54802,Q7Z4W1 Activated ntrk2 signals through cdk5 2 3 4.818060200668897 0.20777186122599708 0.5592939235956129 P63000,Q00535 Assembly of the orc complex at the origin of replication 8 20 1.606791778373548 0.20795175858178722 0.5592939235956129 O43913,O60684,P16104,P52294,P62805,Q14974,Q9UBD5,Q9Y619 Signaling by insulin receptor 16 45 1.3301816833518725 0.22291758678165674 0.5985184521808865 P21281,P21283,P27361,P28482,P31751,P36543,P38606,P61421,P62993,Q06124,Q15904,Q93050,Q99570,Q9UI12,Q9Y487,Q9Y5K8 Regulated necrosis 15 42 1.3393423655432388 0.22697539446516515 0.6083716555921008 O00560,O15294,O75955,P04637,P07900,P09429,P41440,P49327,Q13546,Q14254,Q16543,Q8WUM4,Q8WUX9,Q9UNE7,Q9UQN3 Tbc rabgaps 14 39 1.349979852249832 0.2310762712564648 0.6183064732596191 P20338,P20339,P51148,P51149,P60520,P61006,P61020,P62330,Q15286,Q4KMP7,Q8TC07,Q9NVG8,Q9UJY4,Q9Y3P9 Estrogen dependent gene expression 30 90 1.2059419311276165 0.2339715136951847 0.6249869394787898 O14646,O15514,O60216,O60341,P07900,P08238,P16104,P17844,P19387,P19388,P24928,P30876,P35269,P50750,P52292,P62487,P62805,P62875,Q02790,Q13547,Q14683,Q15185,Q15648,Q86X55,Q8N3U4,Q8WVM7,Q99873,Q9HCE1,Q9HCL2,Q9UQE7 Rnd1 gtpase cycle 13 36 1.362479384678255 0.2352018840604809 0.6272050241612824 O43396,O75976,P02786,P15924,P31948,P38159,P51648,Q03001,Q14254,Q15058,Q8TAA9,Q9NNW5,Q9Y2U8 Signaling by nuclear receptors 57 178 1.1368381038196742 0.23766121103066826 0.6326872307234088 O00330,O00767,O14646,O14980,O15514,O43815,O60216,O60341,P04792,P04899,P07900,P08238,P08559,P08754,P09622,P10515,P11177,P16104,P17844,P19387,P19388,P24928,P27361,P28482,P30876,P31751,P35269,P49327,P50416,P50750,P52292,P53041,P62487,P62805,P62875,P63096,Q02790,Q08752,Q13451,Q13547,Q14683,Q15118,Q15120,Q15185,Q15648,Q86X55,Q8N3U4,Q8NB78,Q8NBN7,Q8TC12,Q8WVM7,Q99873,Q9HBH5,Q9HCE1,Q9HCL2,Q9UBI6,Q9UQE7 Regulation of tp53 activity through acetylation 11 30 1.3954165857448049 0.24340536618635167 0.6334515059732243 O94776,O95983,P04637,P31751,Q13526,Q13547,Q14839,Q86YP4,Q8TBX8,Q8WXI9,Q92769 Phosphorylation of emi1 3 6 2.409166945466711 0.24360411868740706 0.6334515059732243 P06493,P14635,P53350 Adenylate cyclase inhibitory pathway 3 6 2.409166945466711 0.24360411868740706 0.6334515059732243 P04899,P08754,P63096 Synthesis of ketone bodies 3 6 2.409166945466711 0.24360411868740706 0.6334515059732243 P24752,P35610,P35914 Vitamin c ascorbate metabolism 3 6 2.409166945466711 0.24360411868740706 0.6334515059732243 P00387,P11166,P78417 Negative feedback regulation of mapk pathway 3 6 2.409166945466711 0.24360411868740706 0.6334515059732243 P27361,P28482,Q02750 Phosphate bond hydrolysis by nudt proteins 3 6 2.409166945466711 0.24360411868740706 0.6334515059732243 P36639,Q9BW91,Q9UKK9 Aflatoxin activation and detoxification 3 6 2.409166945466711 0.24360411868740706 0.6334515059732243 O14880,O43488,Q99735 Pp2a mediated dephosphorylation of key metabolic factors 3 6 2.409166945466711 0.24360411868740706 0.6334515059732243 P30153,P30154,Q14738 Oas antiviral response 3 6 2.409166945466711 0.24360411868740706 0.6334515059732243 P21333,P61221,Q6L8Q7 Collagen biosynthesis and modifying enzymes 11 30 1.3954165857448049 0.24340536618635167 0.6334515059732243 O00469,O15460,O60568,O75718,P07237,P13674,P23284,P50454,Q02809,Q32P28,Q8NBJ5 Biosynthesis of specialized proresolving mediators spms 3 6 2.409166945466711 0.24360411868740706 0.6334515059732243 P09960,P34913,Q14914 Methionine salvage pathway 3 6 2.409166945466711 0.24360411868740706 0.6334515059732243 P17174,Q13126,Q9BV57 Endosomal sorting complex required for transport escrt 11 30 1.3954165857448049 0.24340536618635167 0.6334515059732243 O14964,O75351,Q8WUX9,Q92783,Q99816,Q9BRG1,Q9H9H4,Q9NP79,Q9NZZ3,Q9UN37,Q9UQN3 Leishmania infection 36 110 1.1734264711260651 0.24650569624726942 0.6399353174101299 O00159,O15143,O15144,O15145,O43865,P04899,P05067,P08238,P08754,P09601,P10644,P13861,P17612,P19174,P27361,P28482,P35579,P46108,P59998,P60953,P61158,P61160,P62993,P63000,P63096,Q16539,Q7L576,Q92747,Q96F07,Q96JJ3,Q9NZQ3,Q9UBI6,Q9UQB8,Q9Y2A7,Q9Y2Z0,Q9Y3E5 Mapk targets nuclear events mediated by map kinases 10 27 1.4177220183848187 0.2473815264723382 0.6411474934026881 P27361,P28482,P30153,P30154,P51452,P51812,Q14738,Q15418,Q16539,Q8IV63 Unblocking of nmda receptors glutamate binding and activation 4 9 1.9274431057563588 0.25542899428131016 0.6544324559364286 P07196,Q13555,Q14168,Q15334 Nef mediated downregulation of mhc class i complex cell surface expression 4 9 1.9274431057563588 0.25542899428131016 0.6544324559364286 O43747,P04439,Q10567,Q9BXS5 Creb1 phosphorylation through nmda receptor mediated activation of ras signaling 8 21 1.4829861827180861 0.2545872453835961 0.6544324559364286 P07196,P27361,P28482,P51812,Q13555,Q14168,Q15334,Q15418 Small interfering rna sirna biogenesis 4 9 1.9274431057563588 0.25542899428131016 0.6544324559364286 O75569,Q15631,Q99598,Q9UPY3 Mucopolysaccharidoses 4 9 1.9274431057563588 0.25542899428131016 0.6544324559364286 P08236,P15586,P16278,P54802 Rhobtb3 atpase cycle 4 9 1.9274431057563588 0.25542899428131016 0.6544324559364286 O14964,O60664,P51151,Q13618 Role of abl in robo slit signaling 4 9 1.9274431057563588 0.25542899428131016 0.6544324559364286 O75122,O94813,Q01518,Q7Z460 Purine salvage 5 12 1.721029221866182 0.2591348687049186 0.6555486256511822 P00491,P00492,P00813,P07741,P55263 Crmps in sema3a signaling 5 12 1.721029221866182 0.2591348687049186 0.6555486256511822 P49841,Q00535,Q14195,Q16555,Q9BPU6 Caspase mediated cleavage of cytoskeletal proteins 5 12 1.721029221866182 0.2591348687049186 0.6555486256511822 P08670,P35611,Q13813,Q15149,Q9UJU6 Sema4d induced cell migration and growth cone collapse 7 18 1.5334551545606823 0.2574166276436418 0.6555486256511822 O75116,P35579,P35580,P60660,P61586,Q13464,Q7Z406 Bbsome mediated cargo targeting to cilium 7 18 1.5334551545606823 0.2574166276436418 0.6555486256511822 P17987,P48643,P49368,P50990,P50991,P78371,Q9NQ48 Raf independent mapk1 3 activation 6 15 1.6063853538736326 0.25920927799982973 0.6555486256511822 P06493,P27361,P28482,Q02750,Q06124,Q99956 Signaling by ctnnb1 phospho site mutants 6 15 1.6063853538736326 0.25920927799982973 0.6555486256511822 P30153,P30154,P35222,P48729,P49841,Q14738 Carnitine metabolism 5 12 1.721029221866182 0.2591348687049186 0.6555486256511822 O00763,O43772,P23786,P50416,Q13085 Ephb mediated forward signaling 14 40 1.2978767370976907 0.26521862131496576 0.6696663417421358 O15143,O15144,O15145,O75116,P23528,P59998,P60953,P61158,P61160,P61586,P63000,Q13464,Q16512,Q92747 Transcriptional regulation by ventx 13 37 1.3055275819626273 0.2711160605530528 0.683456564223773 P04637,P30260,P35222,Q16763,Q96DE5,Q96KQ7,Q9H1A4,Q9HCE1,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6 Ion channel transport 27 82 1.1836455618580408 0.272970324196228 0.6870264339320795 P05023,P05026,P16615,P20020,P21281,P21283,P27105,P30626,P36543,P38606,P51790,P51798,P54709,P61421,P98194,Q12797,Q13546,Q13555,Q15904,Q4KMQ2,Q93050,Q9C0H2,Q9H4A3,Q9HD20,Q9UI12,Q9Y487,Q9Y5K8 Rna polymerase ii transcribes snrna genes 24 73 1.1807580174927115 0.2917659366946147 0.7273741239385106 O00267,O15514,P19387,P19388,P24928,P29083,P30876,P35269,P50750,P62487,P62875,Q00403,Q09161,Q5TA45,Q5VT52,Q68E01,Q8N201,Q96P16,Q96SY0,Q9BXP5,Q9H814,Q9NQG5,Q9NV88,Q9NVM9 Inhibition of dna recombination at telomere 10 28 1.3387733810269022 0.29015076663447503 0.7273741239385106 O15514,P16104,P19387,P19388,P24928,P30876,P62487,P62805,P62875,Q9NYB0 Synthesis of substrates in n glycan biosythesis 15 44 1.2466264348510998 0.29364019161548294 0.7273741239385106 O60762,O95394,P10619,P16278,P34949,Q06210,Q13630,Q16222,Q86YN1,Q8NFW8,Q96IJ6,Q9NR45,Q9UJ70,Q9Y5P6,Q9Y673 Digestion and absorption 1 1 inf 0.29344841113607484 0.7273741239385106 O00625 Synthesis of lipoxins lx 1 1 inf 0.29344841113607484 0.7273741239385106 Q14914 Digestion 1 1 inf 0.29344841113607484 0.7273741239385106 O00625 Assembly and cell surface presentation of nmda receptors 10 28 1.3387733810269022 0.29015076663447503 0.7273741239385106 O14936,P04350,P07196,P68371,Q13555,Q13885,Q14168,Q15334,Q9BUF5,Q9BVA1 Biosynthesis of maresins 1 1 inf 0.29344841113607484 0.7273741239385106 P34913 Passive transport by aquaporins 1 1 inf 0.29344841113607484 0.7273741239385106 Q99797 Synthesis of epoxy eet and dihydroxyeicosatrienoic acids dhet 1 1 inf 0.29344841113607484 0.7273741239385106 P34913 Homologous dna pairing and strand exchange 14 41 1.2496331119568191 0.30096815653051784 0.7443502672552871 O60934,P15927,P27694,P35244,P35249,P35250,P38398,P40937,P40938,P49959,P51530,P54132,Q92878,Q9UQ84 Sulfur amino acid metabolism 8 22 1.3768671007276905 0.3040254447272014 0.7495470083840438 P00505,P17174,P23526,P25325,Q13126,Q99707,Q9BV57,Q9UBX3 Egfr downregulation 8 22 1.3768671007276905 0.3040254447272014 0.7495470083840438 O14964,P22681,P42566,P60953,P62993,Q92783,Q99961,Q9UBC2 Rab geranylgeranylation 18 54 1.2051109616677875 0.3048542453554537 0.7504104501057322 P20338,P20339,P51148,P51149,P51151,P51153,P61006,P61019,P61020,P61026,P61106,P62820,Q15286,Q92696,Q969Q5,Q9H0U4,Q9NP72,Q9UL25 Diseases of mitotic cell cycle 13 38 1.2531319234642497 0.30868259320053604 0.7574558781509242 P11802,P24941,P30260,Q00534,Q13309,Q16763,Q96DE5,Q9H1A4,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6 Esr mediated signaling 43 136 1.1149141134045804 0.30830702553476874 0.7574558781509242 O14646,O14980,O15514,O43815,O60216,O60341,P04792,P04899,P07900,P08238,P08754,P16104,P17844,P19387,P19388,P24928,P27361,P28482,P30876,P31751,P35269,P50750,P52292,P53041,P62487,P62805,P62875,P63096,Q02790,Q08752,Q13451,Q13547,Q14683,Q15185,Q15648,Q86X55,Q8N3U4,Q8WVM7,Q99873,Q9HCE1,Q9HCL2,Q9UBI6,Q9UQE7 Striated muscle contraction 6 16 1.4455458807769592 0.31869407488173473 0.7771575574098912 P06753,P08670,P09493,P28289,P67936,Q9NYL9 Basigin interactions 6 16 1.4455458807769592 0.31869407488173473 0.7771575574098912 P05026,P05556,P08195,P35613,P53985,P54709 Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 6 16 1.4455458807769592 0.31869407488173473 0.7771575574098912 A5YKK6,P04637,P06748,Q92600,Q9C0C2,Q9UIV1 Beta catenin phosphorylation cascade 6 16 1.4455458807769592 0.31869407488173473 0.7771575574098912 P30153,P30154,P35222,P48729,P49841,Q14738 Sphingolipid de novo biosynthesis 10 29 1.2681351265487664 0.33469460528233763 0.7888728427379121 O15269,O15270,O95292,O95470,P22059,P27544,P51648,Q06136,Q96G23,Q9P0L0 Metabolic disorders of biological oxidation enzymes 5 13 1.5056913290927352 0.32606134319228136 0.7888728427379121 P22570,P23526,P48506,P48507,P48637 Nef and signal transduction 2 4 2.408695652173913 0.3367519482112816 0.7888728427379121 P63000,Q13177 Reduction of cytosolic ca levels 3 7 1.8066242890598863 0.3380883611733909 0.7888728427379121 P16615,P20020,P30626 Dissolution of fibrin clot 3 7 1.8066242890598863 0.3380883611733909 0.7888728427379121 P07355,P35237,P60903 Runx1 regulates expression of components of tight junctions 2 4 2.408695652173913 0.3367519482112816 0.7888728427379121 Q07157,Q16625 Glycerophospholipid catabolism 2 4 2.408695652173913 0.3367519482112816 0.7888728427379121 Q8IY17,Q8N9F7 The nlrp3 inflammasome 4 10 1.6059794734493529 0.3329485353303352 0.7888728427379121 P05067,P08238,P09601,Q9Y2Z0 Transport and synthesis of paps 2 4 2.408695652173913 0.3367519482112816 0.7888728427379121 O43252,Q8TB61 Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation 3 7 1.8066242890598863 0.3380883611733909 0.7888728427379121 P00374,P07900,P35270 Synthesis of leukotrienes lt and eoxins ex 2 4 2.408695652173913 0.3367519482112816 0.7888728427379121 P09960,Q14914 Signaling by mapk mutants 2 4 2.408695652173913 0.3367519482112816 0.7888728427379121 P28482,Q99956 Apex1 independent resolution of ap sites via the single nucleotide replacement pathway 3 7 1.8066242890598863 0.3380883611733909 0.7888728427379121 P18887,P49916,Q96T60 Disinhibition of snare formation 2 4 2.408695652173913 0.3367519482112816 0.7888728427379121 O00186,Q12846 Telomere c strand synthesis initiation 5 13 1.5056913290927352 0.32606134319228136 0.7888728427379121 P09884,P49642,P49643,Q14181,Q9NYB0 Aryl hydrocarbon receptor signalling 3 7 1.8066242890598863 0.3380883611733909 0.7888728427379121 O00170,P08238,Q15185 Ketone body metabolism 3 7 1.8066242890598863 0.3380883611733909 0.7888728427379121 P24752,P35610,P35914 Met interacts with tns proteins 2 4 2.408695652173913 0.3367519482112816 0.7888728427379121 P05556,Q9NWH9 Heme degradation 3 7 1.8066242890598863 0.3380883611733909 0.7888728427379121 P09601,P30519,P53004 Interleukin 9 signaling 2 4 2.408695652173913 0.3367519482112816 0.7888728427379121 P40763,P42224 Endosomal vacuolar pathway 4 10 1.6059794734493529 0.3329485353303352 0.7888728427379121 P01889,P04439,P10321,Q9UIQ6 Triglyceride catabolism 5 13 1.5056913290927352 0.32606134319228136 0.7888728427379121 O60664,P17612,P43304,P62136,P62140 Stat5 activation 2 4 2.408695652173913 0.3367519482112816 0.7888728427379121 P62993,Q06124 Proton coupled monocarboxylate transport 2 4 2.408695652173913 0.3367519482112816 0.7888728427379121 P35613,P53985 Mastl facilitates mitotic progression 4 10 1.6059794734493529 0.3329485353303352 0.7888728427379121 P06493,P14635,P30153,P30154 G1 s specific transcription 10 29 1.2681351265487664 0.33469460528233763 0.7888728427379121 O75419,P00374,P04183,P04818,P06493,P09884,P12004,P31350,Q13547,Q9Y619 Gamma carboxylation hypusine formation and arylsulfatase activation 10 29 1.2681351265487664 0.33469460528233763 0.7888728427379121 O43681,O60725,P13639,P38435,P49366,P63241,Q9BQC3,Q9BU89,Q9H2P9,Q9HA64 Enos activation 3 7 1.8066242890598863 0.3380883611733909 0.7888728427379121 O75608,P07900,P35270 Interleukin 6 family signaling 4 10 1.6059794734493529 0.3329485353303352 0.7888728427379121 P22681,P40763,P42224,Q06124 Phase i functionalization of compounds 13 39 1.2047667002349782 0.3474857541722142 0.8083941580742313 O00170,O43169,P00387,P05091,P07099,P08238,P11766,P16435,P22570,P30837,Q15185,Q16850,Q5VT66 Mtor signalling 13 39 1.2047667002349782 0.3474857541722142 0.8083941580742313 P06730,P23588,P31751,P31946,P42345,P54619,P62753,P62942,Q04637,Q6IAA8,Q96B36,Q9Y2Q5,Q9Y376 Epha mediated growth cone collapse 8 23 1.2848972296693477 0.35526805249663784 0.8252745278736714 O75116,P35579,P35580,P60660,P61586,Q13464,Q15375,Q7Z406 Signaling by ptk6 12 36 1.2046979865771812 0.35764753278441586 0.8295729754526096 P11802,P18031,P22681,P23246,P24941,P40763,P46108,P61586,P63000,Q07666,Q8IZL8,Q96JJ3 Signaling by ntrks 32 102 1.1017760617760617 0.36109555904953505 0.8363335843274313 O94973,O95782,P09496,P11233,P19174,P27361,P28482,P30153,P30154,P31946,P40763,P46108,P46109,P50570,P51452,P51812,P53680,P61586,P62993,P63000,P63010,Q00535,Q00610,Q02750,Q06124,Q14738,Q14839,Q15418,Q16539,Q8IV63,Q8WX92,Q96CW1 Rhob gtpase cycle 22 69 1.1279747832939322 0.3639639335938904 0.8417336989310031 O00161,O60610,O75116,O75955,P02786,P14923,P27105,P41440,P63167,Q07960,Q13464,Q14254,Q16512,Q16513,Q8TAA9,Q92888,Q92974,Q9H0H5,Q9H2G2,Q9NQW6,Q9NSV4,Q9UDY2 Metalloprotease dubs 7 20 1.2971781986857365 0.3669342422205733 0.8448647456708648 O00487,O95630,P38398,Q15018,Q92783,Q9NWV8,Q9NXR7 Nucleotide salvage 7 20 1.2971781986857365 0.3669342422205733 0.8448647456708648 P00491,P00492,P00813,P04183,P07741,P55263,Q9BZX2 Cell cell communication 25 79 1.1156674031631901 0.36633425124369734 0.8448647456708648 O14936,O43707,O60716,P05556,P12814,P14923,P19022,P21333,P35221,P35222,P46940,P55196,P62993,Q01082,Q03001,Q06124,Q08722,Q13418,Q13813,Q14315,Q15149,Q15404,Q96AC1,Q9Y5K6,Q9Y624 Glycerophospholipid biosynthesis 27 86 1.1027810329550976 0.37642165639374525 0.8634808858955388 O14735,O15228,O75131,O95674,O96017,P19784,P35790,P40939,P43304,P48651,P48739,P55084,P67870,Q53H12,Q8IV08,Q8NCC3,Q8NF37,Q92604,Q96N66,Q99829,Q99943,Q9BZF1,Q9HCL2,Q9NPH0,Q9NQZ5,Q9NUQ2,Q9UG56 Tp53 regulates transcription of cell cycle genes 14 43 1.1631273013593941 0.375831093557675 0.8634808858955388 A5YKK6,O14965,P04637,P06493,P06748,P12004,P14635,P24941,Q86X55,Q92600,Q99873,Q9C0C2,Q9UIV1,Q9Y3B8 Regulation of tp53 activity 45 146 1.0738727418720835 0.376671508898309 0.8634808858955388 O14744,O14965,O60934,O94776,O95983,O96017,P04637,P06493,P15927,P19784,P24941,P27694,P30153,P30154,P31751,P35244,P35249,P35250,P38398,P40937,P40938,P42345,P49959,P51530,P54132,P54619,P67870,Q00535,Q08945,Q13526,Q13547,Q14839,Q16539,Q86YP4,Q8TBX8,Q8WXI9,Q92769,Q92804,Q92878,Q93009,Q96KQ7,Q9ULW0,Q9UQ84,Q9Y3T9,Q9Y5B9 Intrinsic pathway for apoptosis 17 53 1.1377777777777778 0.380146241881672 0.8638685612615388 P04637,P27348,P27361,P28482,P30419,P31751,P31946,P40763,P61981,P62258,P63104,P63167,Q04917,Q07021,Q96FJ2,Q9NR28,Q9Y3B8 Miscellaneous transport and binding events 6 17 1.3139499482433172 0.37983836904031987 0.8638685612615388 P35611,Q8N4V1,Q8TDW0,Q9H0U3,Q9UEY8,Q9UNS2 Negative regulation of fgfr4 signaling 6 17 1.3139499482433172 0.37983836904031987 0.8638685612615388 P22681,P27361,P28482,P30153,P62993,Q06124 Negative regulation of fgfr3 signaling 6 17 1.3139499482433172 0.37983836904031987 0.8638685612615388 P22681,P27361,P28482,P30153,P62993,Q06124 Negative regulation of fgfr2 signaling 6 17 1.3139499482433172 0.37983836904031987 0.8638685612615388 P22681,P27361,P28482,P30153,P62993,Q06124 Negative regulation of fgfr1 signaling 6 17 1.3139499482433172 0.37983836904031987 0.8638685612615388 P22681,P27361,P28482,P30153,P62993,Q06124 Akt phosphorylates targets in the cytosol 5 14 1.3382063013800543 0.39437604891049405 0.8884793745569751 O15111,P31751,P49840,P49841,Q96B36 Constitutive signaling by egfrviii 5 14 1.3382063013800543 0.39437604891049405 0.8884793745569751 P07900,P19174,P22681,P62993,Q16543 Cytosolic sulfonation of small molecules 5 14 1.3382063013800543 0.39437604891049405 0.8884793745569751 O43252,O95861,Q8TB61,Q96IU4,Q9NX62 Transport of connexons to the plasma membrane 5 14 1.3382063013800543 0.39437604891049405 0.8884793745569751 P04350,P68371,Q13885,Q9BUF5,Q9BVA1 Budding and maturation of hiv virion 9 27 1.2044921220248073 0.39318119232196114 0.8884793745569751 O75351,Q8WUM4,Q8WUX9,Q99816,Q9H9H4,Q9NP79,Q9NZZ3,Q9UN37,Q9UQN3 Gastrin creb signalling pathway via pkc and mapk 5 14 1.3382063013800543 0.39437604891049405 0.8884793745569751 P27361,P28482,P51812,P62993,Q15418 Rna polymerase ii transcription 288 969 1.0202017569011808 0.4061762295489404 0.9127849542324634 A5YKK6,O00148,O00231,O00232,O00267,O00483,O00487,O14497,O14744,O14818,O14965,O15047,O15514,O43148,O43242,O43809,O43819,O60244,O60508,O60934,O75152,O75448,O75832,O75880,O94776,O94925,O95983,O96017,O96019,P00390,P00403,P04179,P04637,P06493,P06744,P06748,P09669,P09874,P10606,P10809,P11413,P11802,P12004,P13073,P14635,P15927,P15954,P16104,P17612,P17931,P17980,P18031,P18074,P18615,P19387,P19388,P19447,P19784,P20618,P20674,P23193,P24928,P24941,P25440,P25786,P25787,P25788,P25789,P26368,P27348,P27361,P27694,P28066,P28070,P28072,P28074,P28482,P29083,P30044,P30153,P30154,P30260,P30876,P31350,P31751,P31946,P32119,P33240,P35222,P35244,P35249,P35250,P35269,P35659,P35998,P38398,P38919,P40937,P40938,P42224,P42345,P42704,P42858,P43246,P43686,P45973,P46087,P48556,P49327,P49720,P49721,P49841,P49959,P50750,P51003,P51530,P51532,P51608,P51665,P54132,P54619,P55036,P60900,P61289,P61964,P61981,P62191,P62195,P62258,P62304,P62318,P62333,P62487,P62805,P62875,P63104,P63208,P67870,P82979,P84103,Q00403,Q00534,Q00535,Q01081,Q03164,Q04917,Q05048,Q05519,Q06124,Q06323,Q07157,Q07955,Q08170,Q08945,Q09161,Q10570,Q12824,Q12996,Q13185,Q13200,Q13242,Q13243,Q13247,Q13263,Q13309,Q13451,Q13526,Q13547,Q13555,Q13573,Q13616,Q13769,Q13838,Q14241,Q14676,Q14739,Q14839,Q14997,Q15008,Q15022,Q15287,Q15291,Q15369,Q15370,Q15648,Q16539,Q16625,Q16629,Q16763,Q16881,Q5KU26,Q5TA45,Q5VT52,Q68E01,Q6IAA8,Q6P1J9,Q6PD62,Q6PL18,Q6UN15,Q7KZ85,Q86U42,Q86U86,Q86V81,Q86W42,Q86X55,Q86YP4,Q8IXH7,Q8IYB3,Q8N201,Q8N684,Q8N7H5,Q8NI27,Q8TAQ2,Q8TBX8,Q8WX92,Q8WXI9,Q8WYQ5,Q92530,Q92600,Q92620,Q92696,Q92769,Q92797,Q92804,Q92878,Q92922,Q93008,Q93009,Q969G3,Q96DE5,Q96EB6,Q96FV9,Q96GM5,Q96J01,Q96J02,Q96KQ7,Q96P16,Q96PK6,Q96ST2,Q96ST3,Q96SY0,Q99436,Q99460,Q99873,Q9BXP5,Q9BXW9,Q9BY77,Q9BZI7,Q9C0C2,Q9C0J8,Q9GZS3,Q9H1A4,Q9H3P2,Q9H814,Q9HCE1,Q9HCL2,Q9NPJ6,Q9NQ88,Q9NQG5,Q9NV88,Q9NVI1,Q9NVM9,Q9NWH9,Q9NYV4,Q9P2I0,Q9UBL3,Q9UHY1,Q9UIV1,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6,Q9UKF6,Q9UL46,Q9ULK4,Q9ULW0,Q9UNE7,Q9UNM6,Q9UPN9,Q9UQ84,Q9Y2Q5,Q9Y2X0,Q9Y3B8,Q9Y3T9,Q9Y3Y2,Q9Y5B9,Q9Y5S9 Metabolism of vitamins and cofactors 41 134 1.0623371701956326 0.4063290166162369 0.9127849542324634 O00763,O00764,O75874,P00374,P00387,P05165,P05166,P07900,P11166,P11498,P11586,P13995,P22033,P34896,P34897,P35270,P41440,P43490,P49327,P50747,P78417,Q13057,Q13085,Q4G0N4,Q6NUM9,Q6UB35,Q8N0U8,Q8NCW5,Q8NFF5,Q8TC12,Q96EY8,Q96RQ3,Q99707,Q9BQG2,Q9H2D1,Q9HC21,Q9HCC0,Q9NQX3,Q9NRN7,Q9NVE7,Q9Y697 Generation of second messenger molecules 4 11 1.3763625932300632 0.41120519805018885 0.9184754281234987 P19174,Q13177,Q16512,Q8N8S7 Long term potentiation 4 11 1.3763625932300632 0.41120519805018885 0.9184754281234987 P07196,Q13555,Q14168,Q15334 Regulation of glycolysis by fructose 2 6 bisphosphate metabolism 4 11 1.3763625932300632 0.41120519805018885 0.9184754281234987 P17612,P30153,P30154,Q14738 Met activates ras signaling 4 11 1.3763625932300632 0.41120519805018885 0.9184754281234987 P62993,Q96P70,Q96S59,Q9NWH9 Diseases of metabolism 40 131 1.0591441079245958 0.4142259774431254 0.9239065898020208 O43505,O60762,O75340,O75874,P05165,P05166,P06865,P07686,P08236,P10253,P10619,P11498,P13807,P15586,P16278,P22033,P22570,P23526,P34949,P36871,P37837,P46976,P48506,P48507,P48637,P50747,P51570,P54802,Q06210,Q13085,Q13724,Q2TAA5,Q7Z4W1,Q8NCH0,Q96EY8,Q96L58,Q96RQ3,Q99707,Q9BT22,Q9HCC0 Class a 1 rhodopsin like receptors 7 21 1.204355108877722 0.42310774064366075 0.9398457610549125 P04083,P05067,P07602,P42892,Q9BYT8,Q9NRV9,Q9NZJ7 Map2k and mapk activation 10 31 1.147040976014819 0.42641872608323184 0.9398457610549125 P18206,P27361,P28482,P30086,P31946,P41240,P46940,Q02750,Q9Y2Q5,Q9Y490 Signaling by mras complex mutants 3 8 1.4450986952157912 0.4315618290558272 0.9398457610549125 P31946,P62140,Q9UQ13 Inactivation of cdc42 and rac1 3 8 1.4450986952157912 0.4315618290558272 0.9398457610549125 O94813,P60953,P63000 Ion homeostasis 10 31 1.147040976014819 0.42641872608323184 0.9398457610549125 O43865,P05023,P05026,P16615,P17612,P20020,P30626,P54709,Q12797,Q13555 Vitamin d calciferol metabolism 3 8 1.4450986952157912 0.4315618290558272 0.9398457610549125 P04062,P38435,Q99538 Interferon alpha beta signaling 10 31 1.147040976014819 0.42641872608323184 0.9398457610549125 P01889,P04439,P10321,P18031,P42224,P55265,P61221,Q06124,Q13325,Q9Y3Z3 Displacement of dna glycosylase by apex1 3 8 1.4450986952157912 0.4315618290558272 0.9398457610549125 P13051,P27695,P29372 Interleukin 27 signaling 3 8 1.4450986952157912 0.4315618290558272 0.9398457610549125 P27824,P40763,P42224 Regulation of ifna signaling 3 8 1.4450986952157912 0.4315618290558272 0.9398457610549125 P18031,P42224,Q06124 Rna polymerase iii transcription initiation from type 1 promoter 10 31 1.147040976014819 0.42641872608323184 0.9398457610549125 O14802,O15160,P19388,P62875,Q12789,Q8WUA4,Q9BUI4,Q9UKN8,Q9Y5Q8,Q9Y5Q9 Synthesis of diphthamide eef2 3 8 1.4450986952157912 0.4315618290558272 0.9398457610549125 P13639,Q9BQC3,Q9H2P9 Sema4d mediated inhibition of cell attachment and migration 3 8 1.4450986952157912 0.4315618290558272 0.9398457610549125 P61586,P63000,Q9NWH9 Lipophagy 3 8 1.4450986952157912 0.4315618290558272 0.9398457610549125 O60664,P11142,P54619 Transport of vitamins nucleosides and related molecules 7 21 1.204355108877722 0.42310774064366075 0.9398457610549125 P05141,P12235,P12236,P36404,Q6P1M0,Q8TB61,Q99808 Activation of the ap 1 family of transcription factors 3 8 1.4450986952157912 0.4315618290558272 0.9398457610549125 P27361,P28482,Q16539 Integration of energy metabolism 22 71 1.0816326530612246 0.4242336872563172 0.9398457610549125 O00763,O43865,O60488,O95573,P04899,P10644,P11166,P13861,P17612,P29401,P29966,P30153,P30154,P37837,P46940,P49327,P53396,P63096,Q13085,Q14738,Q99943,Q9UBI6 Neurexins and neuroligins 9 28 1.1409390052402208 0.4419850781713734 0.9585513175279577 O14936,O43491,P11171,Q14168,Q15334,Q96HC4,Q9HCM4,Q9UJU6,Q9Y2J2 Tgf beta receptor signaling activates smads 9 28 1.1409390052402208 0.4419850781713734 0.9585513175279577 O14980,P22681,P61081,P62136,P62140,P62942,Q9UNE7,Q9Y3F4,Q9Y5K5 Adherens junctions interactions 6 18 1.204286671131949 0.4410492397467304 0.9585513175279577 O60716,P14923,P19022,P35221,P35222,P55196 Fbxw7 mutants and notch1 in cancer 2 5 1.6055741360089186 0.458274002951101 0.9723594541641765 P63208,Q13616 Interleukin 23 signaling 2 5 1.6055741360089186 0.458274002951101 0.9723594541641765 P07237,P40763 Sumo is conjugated to e1 uba2 sae1 2 5 1.6055741360089186 0.458274002951101 0.9723594541641765 Q9UBE0,Q9UBT2 Interleukin 21 signaling 2 5 1.6055741360089186 0.458274002951101 0.9723594541641765 P40763,P42224 Cd163 mediating an anti inflammatory response 2 5 1.6055741360089186 0.458274002951101 0.9723594541641765 P35579,Q16539 Fructose metabolism 2 5 1.6055741360089186 0.458274002951101 0.9723594541641765 P15121,Q00796 Myoclonic epilepsy of lafora 2 5 1.6055741360089186 0.458274002951101 0.9723594541641765 P13807,P46976 Synthesis of pi 2 5 1.6055741360089186 0.458274002951101 0.9723594541641765 O14735,O96017 Chylomicron assembly 2 5 1.6055741360089186 0.458274002951101 0.9723594541641765 P07237,Q9Y6B6 Galactose catabolism 2 5 1.6055741360089186 0.458274002951101 0.9723594541641765 P51570,Q96G03 P75ntr negatively regulates cell cycle via sc1 2 5 1.6055741360089186 0.458274002951101 0.9723594541641765 Q13547,Q92769 Pd 1 signaling 2 5 1.6055741360089186 0.458274002951101 0.9723594541641765 P41240,Q06124 Ptk6 regulates cell cycle 2 5 1.6055741360089186 0.458274002951101 0.9723594541641765 P11802,P24941 Acyl chain remodeling of cl 2 5 1.6055741360089186 0.458274002951101 0.9723594541641765 P40939,P55084 Arms mediated activation 2 5 1.6055741360089186 0.458274002951101 0.9723594541641765 P31946,P46108 Rhot1 gtpase cycle 2 5 1.6055741360089186 0.458274002951101 0.9723594541641765 P52306,Q8IXI2 Signaling by wnt in cancer 8 25 1.1334174420438416 0.45925308668164777 0.9731200539416537 P30153,P30154,P35222,P48729,P49841,P56545,Q13363,Q14738 Platelet sensitization by ldl 5 15 1.2042182792099096 0.46195943435990494 0.9735962552461518 P30153,P30154,Q06124,Q14738,Q16539 Gap junction assembly 5 15 1.2042182792099096 0.46195943435990494 0.9735962552461518 P04350,P68371,Q13885,Q9BUF5,Q9BVA1 Rab gefs exchange gtp for gdp on rabs 24 79 1.0510659152168587 0.4619614884586333 0.9735962552461518 P20339,P31150,P31751,P50395,P51148,P51149,P51151,P51153,P61006,P61020,P61026,P61106,P62258,P62820,Q14C86,Q15042,Q15286,Q7Z392,Q8IUR0,Q9H0U4,Q9H2M9,Q9NP72,Q9UL25,Q9Y296 Growth hormone receptor signaling 5 15 1.2042182792099096 0.46195943435990494 0.9735962552461518 P18031,P27361,P28482,P40763,P42224 Nuclear events kinase and transcription factor activation 13 42 1.0796842263661723 0.46703369146383666 0.9803331033671967 P27361,P28482,P30153,P30154,P50570,P51452,P51812,Q00535,Q14738,Q14839,Q15418,Q16539,Q8IV63 Formation of incision complex in gg ner 13 42 1.0796842263661723 0.46703369146383666 0.9803331033671967 P09874,P15927,P18074,P19447,P27694,P35244,P41208,P54727,P61088,Q13620,Q16531,Q86WJ1,Q9UGN5 Rna polymerase i promoter escape 13 42 1.0796842263661723 0.46703369146383666 0.9803331033671967 O15160,O15446,O95602,P16104,P17480,P18074,P19388,P19447,P62805,P62875,Q13185,Q9GZS1,Q9H9Y6 Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein 18 59 1.0574081060245706 0.4708911927950181 0.9871088105649578 O60762,O75340,O95394,P10619,P16278,P34949,Q06210,Q13630,Q16222,Q2TAA5,Q86YN1,Q8NFW8,Q96IJ6,Q9BT22,Q9NR45,Q9UJ70,Q9Y5P6,Q9Y673 Rna polymerase i transcription termination 10 32 1.0947503201024327 0.4723010351743333 0.9887423540098192 O15160,O15446,O95602,P17480,P18074,P19388,P19447,P62875,Q9GZS1,Q9H9Y6 Signaling by csf3 g csf 7 22 1.1239084310441094 0.47867947873342515 0.9967721416387924 P40763,P42224,P62993,Q06124,Q15369,Q15370,Q93034 Signal amplification 7 22 1.1239084310441094 0.47867947873342515 0.9967721416387924 P04899,P08754,P63096,Q13685,Q14344,Q16539,Q9UBI6 Flt3 signaling in disease 7 22 1.1239084310441094 0.47867947873342515 0.9967721416387924 P22681,P62993,Q01082,Q06124,Q14789,Q92614,Q9UBW7 Translation of sars cov 1 structural proteins 7 22 1.1239084310441094 0.47867947873342515 0.9967721416387924 P14314,P27824,P49840,P49841,Q10472,Q13724,Q14697 Muscle contraction 25 83 1.0381437188382552 0.4795677841706032 0.9972974609807769 O43865,P04083,P05023,P05026,P06753,P07355,P08133,P08670,P09493,P16615,P17612,P18206,P20020,P28289,P30626,P54709,P60660,P67936,Q05682,Q12797,Q13177,Q13555,Q16512,Q9NYL9,Q9Y490 Interaction between l1 and ankyrins 4 12 1.2041499330655958 0.4872403627234796 0.9986835147064261 O15020,Q01082,Q12955,Q13813 Costimulation by the cd28 family 12 39 1.0703952274422073 0.48249239708589586 0.9986835147064261 P30153,P30154,P31751,P41240,P42345,P60953,P62993,P63000,Q06124,Q13177,Q14738,Q16512 Purinergic signaling in leishmaniasis infection 4 12 1.2041499330655958 0.4872403627234796 0.9986835147064261 P05067,P08238,P09601,Q9Y2Z0 Rab regulation of trafficking 32 107 1.0276036036036036 0.485643977921301 0.9986835147064261 P20338,P20339,P31150,P31751,P50395,P51148,P51149,P51151,P51153,P60520,P61006,P61020,P61026,P61106,P62258,P62330,P62820,Q14C86,Q15042,Q15286,Q4KMP7,Q7Z392,Q8IUR0,Q8TC07,Q9H0U4,Q9H2M9,Q9NP72,Q9NVG8,Q9UJY4,Q9UL25,Q9Y296,Q9Y3P9 Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 4 12 1.2041499330655958 0.4872403627234796 0.9986835147064261 P35222,P61009,P67812,Q15005 Regulation of pten gene transcription 17 56 1.0498168498168499 0.4840980393535641 0.9986835147064261 O60341,O94776,O95983,P04637,P27361,P28482,P42345,Q13330,Q13547,Q14839,Q15022,Q6IAA8,Q86YP4,Q8WXI9,Q92769,Q9UKL0,Q9Y2Q5 Activation of rac1 4 12 1.2041499330655958 0.4872403627234796 0.9986835147064261 O94813,P63000,Q13177,Q16512 Inflammasomes 4 12 1.2041499330655958 0.4872403627234796 0.9986835147064261 P05067,P08238,P09601,Q9Y2Z0 Loss of function of mecp2 in rett syndrome 4 12 1.2041499330655958 0.4872403627234796 0.9986835147064261 P17612,P51608,Q13547,Q96ST3 Mitochondrial iron sulfur cluster biogenesis 4 12 1.2041499330655958 0.4872403627234796 0.9986835147064261 P22570,Q86SX6,Q9H1K1,Q9Y697 Cytosolic sensors of pathogen associated dna 17 56 1.0498168498168499 0.4840980393535641 0.9986835147064261 O14802,O15111,O15160,P12956,P13010,P19388,P19474,P35222,P49959,P62875,P78527,Q08211,Q13546,Q9BUI4,Q9H2U1,Q9NZI8,Q9UJV9 Phospholipid metabolism 43 156 0.9150034359930019 0.7165863463128426 1.0 O00443,O14735,O15228,O75131,O95674,O96017,P19784,P20338,P20339,P35790,P40939,P42356,P43304,P48651,P48739,P55084,P61106,P67870,Q01968,Q10713,Q13614,Q53H12,Q8IV08,Q8IY17,Q8N9F7,Q8NCC3,Q8NF37,Q8TBX8,Q92604,Q96N66,Q96T51,Q99570,Q99829,Q99943,Q9BTU6,Q9BZF1,Q9HCL2,Q9NPH0,Q9NQZ5,Q9NTJ5,Q9NUQ2,Q9UBF8,Q9UG56 Runx2 regulates genes involved in cell migration 1 5 0.6018054162487463 0.8239879431862632 1.0 P31751 Runx2 regulates bone development 3 26 0.31336640144297206 0.9919433614038574 1.0 P27361,P28482,Q96PK6 Ldl remodeling 1 2 2.4082246740220663 0.5008051893494083 1.0 P07237 Runx1 regulates transcription of genes involved in differentiation of myeloid cells 1 5 0.6018054162487463 0.8239879431862632 1.0 P17931 Runx1 regulates transcription of genes involved in interleukin signaling 0 4 0.0 1.0 1.0 Runx1 regulates transcription of genes involved in wnt signaling 0 3 0.0 1.0 1.0 Runx1 regulates transcription of genes involved in differentiation of keratinocytes 0 4 0.0 1.0 1.0 Runx1 regulates transcription of genes involved in bcr signaling 0 4 0.0 1.0 1.0 Dag and ip3 signaling 7 30 0.7321680868108659 0.8214386241493598 1.0 O43865,P10644,P13861,P17612,P19174,P52292,Q13555 Runx2 regulates chondrocyte maturation 0 3 0.0 1.0 1.0 Runx1 interacts with co factors whose precise effect on runx1 targets is not known 11 36 1.059630996309963 0.4992096541396956 1.0 O14497,O96019,P19784,P51532,P67870,Q12824,Q86U86,Q8TAQ2,Q92922,Q969G3,Q96GM5 Synthesis of glycosylphosphatidylinositol gpi 0 12 0.0 1.0 1.0 Vldl clearance 0 4 0.0 1.0 1.0 Hdl remodeling 0 3 0.0 1.0 1.0 Runx2 regulates osteoblast differentiation 2 20 0.2670382757339279 0.9911014099285991 1.0 P27361,P28482 Chylomicron remodeling 0 4 0.0 1.0 1.0 Chylomicron clearance 0 4 0.0 1.0 1.0 Transcriptional regulation by e2f6 6 34 0.5149746435747775 0.9604315162740189 1.0 P31350,P38398,P45973,Q13185,Q15022,Q96KQ7 Runx3 regulates bcl2l11 bim transcription 0 5 0.0 1.0 1.0 Runx3 regulates p14 arf 1 11 0.24052156469408226 0.9781420785502122 1.0 P25440 Removal of aminoterminal propeptides from gamma carboxylated proteins 0 4 0.0 1.0 1.0 Runx3 regulates yap1 mediated transcription 0 6 0.0 1.0 1.0 Gamma carboxylation transport and amino terminal cleavage of proteins 1 5 0.6018054162487463 0.8239879431862632 1.0 P38435 Recycling of bile acids and salts 0 6 0.0 1.0 1.0 Carboxyterminal post translational modifications of tubulin 6 25 0.7598618112595622 0.786880197836483 1.0 P04350,P68371,Q13885,Q14166,Q9BUF5,Q9BVA1 Activation of matrix metalloproteinases 0 6 0.0 1.0 1.0 Runx3 regulates wnt signaling 1 8 0.3437455222811291 0.9379623427931464 1.0 P35222 Zbp1 dai mediated induction of type i ifns 4 18 0.6875119525721936 0.8205132217227086 1.0 O15111,Q08211,Q13546,Q9NZI8 Irf3 mediated activation of type 1 ifn 1 3 1.2039451688398528 0.6473218534129999 1.0 Q9NZI8 Sulfide oxidation to sulfate 1 5 0.6018054162487463 0.8239879431862632 1.0 Q9UBX3 Polo like kinase mediated events 3 16 0.5551895411380189 0.8908482493424653 1.0 P14635,P53350,Q99640 Runx3 regulates immune response and cell migration 0 4 0.0 1.0 1.0 Fibronectin matrix formation 1 3 1.2039451688398528 0.6473218534129999 1.0 P05556 Degradation of cysteine and homocysteine 3 12 0.8023865283818445 0.7313126477609548 1.0 P00505,P25325,Q9UBX3 Elastic fibre formation 1 23 0.10914561867420443 0.999664397240253 1.0 P05556 G0 and early g1 5 26 0.5725604604077988 0.9166742426731277 1.0 P06493,P11388,P12004,P24941,Q13547 Assembly of active lpl and lipc lipase complexes 1 7 0.401092165385044 0.9121715035098086 1.0 Q9BU23 Hdl assembly 1 6 0.4813774657305249 0.8756637428026797 1.0 P17612 Regulation of pten localization 1 8 0.3437455222811291 0.9379623427931464 1.0 Q93009 Competing endogenous rnas cernas regulate pten translation 1 8 0.3437455222811291 0.9379623427931464 1.0 Q9HCE1 Plasma lipoprotein assembly 3 12 0.8023865283818445 0.7313126477609548 1.0 P07237,P17612,Q9Y6B6 Collagen chain trimerization 0 13 0.0 1.0 1.0 Plasma lipoprotein remodeling 2 12 0.4812040133779264 0.9075099812904823 1.0 P07237,Q9BU23 Regulation of pten mrna translation 1 9 0.3007355399531929 0.9561814898792792 1.0 Q9HCE1 Runx3 regulates notch signaling 1 11 0.24052156469408226 0.9781420785502122 1.0 Q13573 Signaling by activin 2 9 0.6877209746774964 0.7922091662556401 1.0 P27361,P28482 Runx3 regulates cdkn1a transcription 1 7 0.401092165385044 0.9121715035098086 1.0 P04637 Cd28 co stimulation 7 24 0.9914080204946301 0.5842864352535018 1.0 P31751,P42345,P60953,P62993,P63000,Q13177,Q16512 Synthesis of active ubiquitin roles of e1 and e2 enzymes 8 26 1.0703008638665474 0.5102183235563419 1.0 A0AVT1,P22314,P45974,P61086,P68036,Q16763,Q93008,Q93009 Runx1 regulates genes involved in megakaryocyte differentiation and platelet function 11 39 0.9457037427517132 0.621795029403864 1.0 O15047,P16104,P61964,P62805,Q03164,Q13547,Q15291,Q96ST3,Q99873,Q9HCE1,Q9UBL3 P38mapk events 2 13 0.43739738522347216 0.9301401965681808 1.0 P11233,Q16539 Platelet aggregation plug formation 5 20 0.8022542126994755 0.7426880917621369 1.0 P18031,P41240,P46108,P62993,Q9Y490 Rna polymerase iii transcription initiation from type 3 promoter 5 30 0.4806829594911282 0.9645851332924127 1.0 O14802,O15160,P19388,P62875,Q9BUI4 Signaling by tgf beta receptor complex 19 67 0.9527693687633143 0.6161694531409745 1.0 O14980,P09874,P22681,P27361,P28482,P50750,P61081,P61586,P62136,P62140,P62942,Q13547,Q13573,Q93008,Q9UNE7,Q9UPN9,Q9Y3F4,Q9Y5K5,Q9Y624 Adenylate cyclase activating pathway 0 3 0.0 1.0 1.0 Ddx58 ifih1 mediated induction of interferon alpha beta 13 57 0.7101223717537917 0.8935610207486278 1.0 O15111,O94826,P05067,P07900,P08238,P09429,P61086,Q13526,Q13546,Q14258,Q15366,Q7Z434,Q96J02 Ticam1 rip1 mediated ikk complex recruitment 3 16 0.5551895411380189 0.8908482493424653 1.0 O15111,P61088,Q13546 Toll like receptor cascades 26 103 0.8113686717867432 0.8482366022704928 1.0 O15111,P05067,P09429,P14625,P27361,P28482,P30153,P30154,P50570,P51452,P51812,P61088,P63208,Q02750,Q06124,Q13546,Q13616,Q14738,Q15075,Q15418,Q15750,Q16539,Q8IV63,Q99538,Q99570,Q9BQ95 Neurotoxicity of clostridium toxins 0 8 0.0 1.0 1.0 Tnf signaling 5 39 0.35300025601134327 0.9958082107547567 1.0 O15111,O95429,P63244,Q13546,Q15750 Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways 10 42 0.7515928906773978 0.8308770083779342 1.0 O15111,P05067,P08238,P09601,P61088,Q13685,Q15750,Q16539,Q96J02,Q9Y2Z0 Toll like receptor tlr1 tlr2 cascade 19 70 0.8963481793659274 0.6999657020837267 1.0 O15111,P05067,P09429,P27361,P28482,P30153,P30154,P51452,P51812,P61088,P63208,Q02750,Q13616,Q14738,Q15418,Q15750,Q16539,Q8IV63,Q9BQ95 Toll like receptor 9 tlr9 cascade 21 75 0.9358988743034519 0.6438182694468256 1.0 O15111,P05067,P09429,P27361,P28482,P30153,P30154,P51452,P51812,P61088,P63208,Q02750,Q13616,Q14738,Q15075,Q15418,Q15750,Q16539,Q8IV63,Q99570,Q9BQ95 Slbp dependent processing of replication dependent histone pre mrnas 3 10 1.031926587965397 0.5996338369181741 1.0 P62304,P62318,Q09161 Trafficking and processing of endosomal tlr 2 8 0.8024526198439242 0.7316356285104274 1.0 P14625,Q99538 Transport of fatty acids 1 3 1.2039451688398528 0.6473218534129999 1.0 Q6P1M0 The fatty acid cycling model 0 1 0.0 1.0 1.0 Interferon gamma signaling 12 51 0.7398038203407331 0.8582578855024988 1.0 O15344,P01889,P04439,P10321,P18031,P19474,P29372,P42224,Q06124,Q12899,Q13555,Q14258 Regulation of ifng signaling 3 10 1.031926587965397 0.5996338369181741 1.0 P18031,P42224,Q06124 Hiv transcription initiation 13 45 0.9780547163477677 0.5829215706476896 1.0 O15514,P18074,P19387,P19388,P19447,P24928,P29083,P30876,P35269,P62487,P62875,Q00403,Q92804 Nod1 2 signaling pathway 6 30 0.601138647019424 0.9122157934436538 1.0 O15111,P61088,Q13685,Q15750,Q16539,Q96J02 Transport of organic anions 0 3 0.0 1.0 1.0 Platelet adhesion to exposed collagen 1 7 0.401092165385044 0.9121715035098086 1.0 P05556 Trail signaling 0 6 0.0 1.0 1.0 Acetylcholine binding and downstream events 0 2 0.0 1.0 1.0 Death receptor signalling 18 120 0.4214169864314253 0.9999275634054623 1.0 O15111,O95429,P49327,P52565,P61586,P62258,P63000,P63244,Q13546,Q13547,Q14344,Q15750,Q92542,Q92769,Q92888,Q92974,Q9NQC3,Q9NY61 Norepinephrine neurotransmitter release cycle 0 12 0.0 1.0 1.0 Serotonin neurotransmitter release cycle 0 14 0.0 1.0 1.0 Base excision repair ap site formation 5 23 0.6682661905293308 0.8495505493646256 1.0 P13051,P16104,P29372,P62805,Q9NYB0 Rip mediated nfkb activation via zbp1 4 16 0.8023203926818384 0.7360995100844776 1.0 O15111,Q08211,Q13546,Q9NZI8 Shc1 events in egfr signaling 1 7 0.401092165385044 0.9121715035098086 1.0 P62993 Rna polymerase iii transcription termination 6 24 0.8021879883902657 0.7499274740177471 1.0 O14802,O15160,P05455,P19388,P62875,Q9BUI4 Rna polymerase iii transcription 11 44 0.8018562003801856 0.7856499149590389 1.0 O14802,O15160,P05455,P19388,P62875,Q12789,Q8WUA4,Q9BUI4,Q9UKN8,Q9Y5Q8,Q9Y5Q9 Alternative complement activation 0 1 0.0 1.0 1.0 Gab1 signalosome 3 10 1.031926587965397 0.5996338369181741 1.0 P41240,P62993,Q06124 Irs activation 0 4 0.0 1.0 1.0 Signal attenuation 3 9 1.2040816326530612 0.5196282464541333 1.0 P27361,P28482,P62993 Insulin receptor signalling cascade 6 31 0.5770127260549229 0.9276030862003526 1.0 P27361,P28482,P31751,P62993,Q06124,Q99570 Signaling by egfr 12 40 1.0320230105465005 0.5233766293220338 1.0 O14964,P19174,P22681,P41240,P42566,P60953,P62993,Q06124,Q13685,Q92783,Q99961,Q9UBC2 Assembly of the hiv virion 2 15 0.37000257267815795 0.9606307441557929 1.0 Q99816,Q9H9H4 Activation of c3 and c5 0 1 0.0 1.0 1.0 Mrna editing 1 4 0.8025186671124485 0.7508451551458319 1.0 P55265 Triglyceride biosynthesis 1 7 0.401092165385044 0.9121715035098086 1.0 Q9HCL2 Fasl cd95l signaling 1 5 0.6018054162487463 0.8239879431862632 1.0 P49327 Chondroitin sulfate dermatan sulfate metabolism 4 32 0.34308663224325875 0.993291517373001 1.0 P06865,P07686,Q8NCH0,Q96L58 Erbb2 activates ptk6 signaling 0 3 0.0 1.0 1.0 Signalling to ras 3 16 0.5551895411380189 0.8908482493424653 1.0 P11233,P62993,Q16539 Terminal pathway of complement 0 1 0.0 1.0 1.0 Negative regulation of activity of tfap2 ap 2 family transcription factors 0 7 0.0 1.0 1.0 Activation of the tfap2 ap 2 family of transcription factors 0 8 0.0 1.0 1.0 Tfap2 ap 2 family regulates transcription of growth factors and their receptors 1 7 0.401092165385044 0.9121715035098086 1.0 Q6PL18 Tfap2 ap 2 family regulates transcription of cell cycle factors 0 5 0.0 1.0 1.0 Signaling by egfr in cancer 5 17 1.0032362459546926 0.5884307536605788 1.0 P07900,P19174,P22681,P62993,Q16543 Met activates ptk2 signaling 2 19 0.28278575644304543 0.9879599699433071 1.0 P05556,Q9NWH9 Creb3 factors activate genes 0 3 0.0 1.0 1.0 Heparan sulfate heparin hs gag metabolism 5 32 0.4449528202457563 0.9774631579137176 1.0 P08236,P16278,P54802,Q7LGA3,Q96L58 Keratan sulfate keratin metabolism 5 17 1.0032362459546926 0.5884307536605788 1.0 O43505,P06865,P07686,P15586,P16278 Pka activation in glucagon signalling 3 12 0.8023865283818445 0.7313126477609548 1.0 P10644,P13861,P17612 Met promotes cell motility 7 29 0.7655550479671083 0.7912410887123539 1.0 P05556,P46108,P46109,P62993,P63000,Q96N67,Q9NWH9 Inla mediated entry of listeria monocytogenes into host cells 2 9 0.6877209746774964 0.7922091662556401 1.0 O60716,P35222 Runx1 and foxp3 control the development of regulatory t lymphocytes tregs 0 3 0.0 1.0 1.0 Glucagon signaling in metabolic regulation 4 21 0.56595007480904 0.9043043121411438 1.0 P10644,P13861,P17612,Q9UBI6 Pka mediated phosphorylation of key metabolic factors 1 4 0.8025186671124485 0.7508451551458319 1.0 P17612 Post translational modification synthesis of gpi anchored proteins 7 32 0.6734070351758794 0.8714557404830116 1.0 O43292,O60762,Q92643,Q969N2,Q96S52,Q9H490,Q9ULX3 Gaba synthesis release reuptake and degradation 2 12 0.4812040133779264 0.9075099812904823 1.0 P11142,P51649 Runx1 regulates estrogen receptor mediated transcription 1 5 0.6018054162487463 0.8239879431862632 1.0 Q9HCL2 Regulation of runx1 expression and activity 3 17 0.515461453902404 0.9142722919386125 1.0 Q00534,Q06124,Q9HCE1 Receptor mediated mitophagy 3 10 1.031926587965397 0.5996338369181741 1.0 P19784,P67870,Q96HS1 Ampk inhibits chrebp transcriptional activation activity 0 7 0.0 1.0 1.0 Pi metabolism 17 71 0.7566137566137566 0.8728598145597574 1.0 O00443,P20338,P20339,P42356,P48739,P61106,Q01968,Q10713,Q13614,Q8IY17,Q8N9F7,Q8TBX8,Q96T51,Q99570,Q9BTU6,Q9NTJ5,Q9UBF8 Vldl assembly 1 3 1.2039451688398528 0.6473218534129999 1.0 P07237 Reelin signalling pathway 0 3 0.0 1.0 1.0 Ptk6 regulates rtks and their effectors akt1 and dok1 1 7 0.401092165385044 0.9121715035098086 1.0 P22681 Ptk6 regulates rho gtpases ras gtpase and map kinases 4 13 1.0702067529376766 0.5588754825262198 1.0 P46108,P61586,P63000,Q96JJ3 Ptk6 expression 1 2 2.4082246740220663 0.5008051893494083 1.0 Q8IZL8 Initial triggering of complement 0 1 0.0 1.0 1.0 Phosphate bond hydrolysis by ntpdase proteins 0 4 0.0 1.0 1.0 Butyrophilin btn family interactions 0 5 0.0 1.0 1.0 Complement cascade 1 10 0.2672833314759092 0.969051322224564 1.0 Q99829 Met activates pi3k akt signaling 2 6 1.2040133779264215 0.5656089450744413 1.0 P62993,Q9NWH9 The activation of arylsulfatases 1 8 0.3437455222811291 0.9379623427931464 1.0 O43681 Signaling by mst1 1 3 1.2039451688398528 0.6473218534129999 1.0 Q13043 Signaling by fgfr3 fusions in cancer 1 10 0.2672833314759092 0.969051322224564 1.0 P62993 Ret signaling 5 26 0.5725604604077988 0.9166742426731277 1.0 P17612,P19174,P62993,Q06124,Q9NR12 Mitochondrial uncoupling 0 1 0.0 1.0 1.0 Myd88 independent tlr4 cascade 20 78 0.8291177426091799 0.7998147856249199 1.0 O15111,P05067,P09429,P27361,P28482,P30153,P30154,P51452,P51812,P61088,P63208,Q02750,Q06124,Q13546,Q13616,Q14738,Q15418,Q15750,Q16539,Q8IV63 Interleukin 20 family signaling 3 11 0.9028103044496487 0.6702945765004975 1.0 P40763,P42224,Q06124 Synthesis of pips at the late endosome membrane 3 10 1.031926587965397 0.5996338369181741 1.0 O00443,Q13614,Q99570 Synthesis of pips at the early endosome membrane 4 16 0.8023203926818384 0.7360995100844776 1.0 O00443,Q13614,Q99570,Q9BTU6 Synthesis of pips at the plasma membrane 9 47 0.5689609541789439 0.9602695077490015 1.0 O00443,P20338,P20339,P61106,Q01968,Q13614,Q8TBX8,Q96T51,Q9BTU6 Ptk6 promotes hif1a stabilization 0 2 0.0 1.0 1.0 Downregulation of erbb2 signaling 5 18 0.9259354639334553 0.6451159513320872 1.0 P07900,P31751,Q16543,Q93034,Q9UNE7 Transcriptional regulation by the ap 2 tfap2 family of transcription factors 5 27 0.5464588976473811 0.9322710956586475 1.0 P06748,P10809,P35659,P46087,Q6PL18 Glycosaminoglycan metabolism 14 70 0.6000671591672263 0.9719519872873841 1.0 O43252,O43505,O75330,P06865,P07686,P08236,P15586,P16278,P54802,Q7LGA3,Q8NCH0,Q8TB61,Q96L58,Q9UHD1 Lipid particle organization 0 1 0.0 1.0 1.0 Rac1 gtpase cycle 38 152 0.8000451365380276 0.900352364140732 1.0 O00161,O15498,P02786,P05556,P42166,P42167,P46940,P50402,P51149,P52565,P60953,P63000,P63167,Q07960,Q13112,Q13177,Q13576,Q14344,Q14739,Q15758,Q16512,Q16513,Q5T2T1,Q68EM7,Q6IAA8,Q7L576,Q86UP2,Q8TAA9,Q96AC1,Q96F07,Q96N67,Q9BSJ8,Q9H0H5,Q9NSV4,Q9UQB8,Q9Y2A7,Q9Y2I1,Q9Y2U8 Inositol phosphate metabolism 5 40 0.34286670811612224 0.9967387252338186 1.0 P19174,Q01968,Q9BW91,Q9NPH2,Q9UNW1 Response of eif2ak1 hri to heme deficiency 3 10 1.031926587965397 0.5996338369181741 1.0 P05198,P08243,P20042 Defects of contact activation system cas and kallikrein kinin system kks 1 5 0.6018054162487463 0.8239879431862632 1.0 P38435 Constitutive signaling by ligand responsive egfr cancer variants 5 17 1.0032362459546926 0.5884307536605788 1.0 P07900,P19174,P22681,P62993,Q16543 Regulation of gene expression by hypoxia inducible factor 0 5 0.0 1.0 1.0 Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects 3 17 0.515461453902404 0.9142722919386125 1.0 P11802,P24941,Q00534 Adora2b mediated anti inflammatory cytokines production 8 30 0.8752132585912746 0.6920206151109443 1.0 P04899,P08754,P10644,P13861,P17612,P63096,Q9UBI6,Q9Y3E5 Defective factor viii causes hemophilia a 0 3 0.0 1.0 1.0 Signaling by erbb2 in cancer 4 17 0.7405004633920297 0.7815360505152051 1.0 P07900,P19174,P62993,Q16543 Anti inflammatory response favouring leishmania parasite infection 12 46 0.8491906829846032 0.7372175012589298 1.0 O43865,P04899,P08754,P10644,P13861,P17612,P19174,P35579,P63096,Q16539,Q9UBI6,Q9Y3E5 Signaling by erbb2 9 37 0.7732388295579714 0.8010744596285829 1.0 O60610,P07900,P19174,P31751,P61586,P62993,Q16543,Q93034,Q9UNE7 Fcgr3a mediated il10 synthesis 5 23 0.6682661905293308 0.8495505493646256 1.0 O43865,P10644,P13861,P17612,P19174 Fertilization 0 3 0.0 1.0 1.0 Killing mechanisms 1 9 0.3007355399531929 0.9561814898792792 1.0 P63000 Pexophagy 1 9 0.3007355399531929 0.9561814898792792 1.0 P50542 Signaling by erbb2 ecd mutants 4 15 0.8753803091152489 0.6838446456385155 1.0 P07900,P19174,P62993,Q16543 Defective factor ix causes hemophilia b 1 3 1.2039451688398528 0.6473218534129999 1.0 P38435 Signaling by nodal 2 12 0.4812040133779264 0.9075099812904823 1.0 P27361,P28482 Signaling by kit in disease 3 18 0.4810304449648712 0.9330241059965461 1.0 P40763,P42224,P62993 Signaling by pdgfr in disease 5 17 1.0032362459546926 0.5884307536605788 1.0 O43815,P40763,P42224,P62993,Q6UN15 Defective f9 activation 0 1 0.0 1.0 1.0 Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants 3 11 0.9028103044496487 0.6702945765004975 1.0 P40763,P42224,P62993 Signaling by membrane tethered fusions of pdgfra or pdgfrb 0 3 0.0 1.0 1.0 Prolactin receptor signaling 3 9 1.2040816326530612 0.5196282464541333 1.0 P63208,Q06124,Q13616 Ras processing 5 19 0.8596776507723947 0.6966080955472779 1.0 O43924,O60725,O75608,P36404,P49356 Diseases of dna repair 10 33 1.0470066777476452 0.5174084723579307 1.0 O60934,P20585,P38398,P43246,P49959,P51530,P52701,P54132,Q92878,Q9UQ84 N glycan trimming and elongation in the cis golgi 0 4 0.0 1.0 1.0 Cross presentation of particulate exogenous antigens phagosomes 0 3 0.0 1.0 1.0 Foxo mediated transcription of oxidative stress metabolic and neuronal genes 4 18 0.6875119525721936 0.8205132217227086 1.0 P04179,Q13547,Q92769,Q96ST3 Late endosomal microautophagy 8 29 0.917017745435976 0.6507823648111599 1.0 O60664,P08670,P11142,Q8WUX9,Q99497,Q99816,Q9H9H4,Q9UQN3 Nuclear signaling by erbb4 3 18 0.4810304449648712 0.9330241059965461 1.0 P16949,P61201,Q92542 Transcriptional regulation of granulopoiesis 7 34 0.6233513245238539 0.9092825641979646 1.0 P11802,P16104,P24941,P35659,P40763,P62805,Q03164 Negative regulation of nmda receptor mediated neuronal transmission 4 14 0.9630522088353414 0.624675255970463 1.0 P07196,Q13555,Q14168,Q15334 Regulation of foxo transcriptional activity by acetylation 1 10 0.2672833314759092 0.969051322224564 1.0 Q96EB6 Foxo mediated transcription of cell cycle genes 0 13 0.0 1.0 1.0 Activation of rac1 downstream of nmdars 1 6 0.4813774657305249 0.8756637428026797 1.0 P63000 Activation of ampk downstream of nmdars 6 21 0.9630274614869391 0.6124722534016208 1.0 P04350,P54619,P68371,Q13885,Q9BUF5,Q9BVA1 Egr2 and sox10 mediated initiation of schwann cell myelination 5 20 0.8022542126994755 0.7426880917621369 1.0 P46939,P51532,Q16850,Q92769,Q9NR77 Nr1h2 nr1h3 regulate gene expression to control bile acid homeostasis 0 6 0.0 1.0 1.0 Nr1h2 nr1h3 regulate gene expression linked to gluconeogenesis 0 4 0.0 1.0 1.0 Shc1 events in erbb4 signaling 1 6 0.4813774657305249 0.8756637428026797 1.0 P62993 Constitutive signaling by overexpressed erbb2 3 11 0.9028103044496487 0.6702945765004975 1.0 P07900,P62993,Q16543 Estrogen stimulated signaling through prkcz 1 6 0.4813774657305249 0.8756637428026797 1.0 P28482 Estrogen dependent nuclear events downstream of esr membrane signaling 4 15 0.8753803091152489 0.6838446456385155 1.0 O14980,P27361,P28482,P31751 Pi3k events in erbb4 signaling 0 2 0.0 1.0 1.0 Shc1 events in erbb2 signaling 1 13 0.2003789145213418 0.9890984267926946 1.0 P62993 Erythrocytes take up oxygen and release carbon dioxide 0 1 0.0 1.0 1.0 Modulation by mtb of host immune system 0 4 0.0 1.0 1.0 Erythrocytes take up carbon dioxide and release oxygen 1 4 0.8025186671124485 0.7508451551458319 1.0 Q9UHQ9 Amino acids regulate mtorc1 11 45 0.778163663989581 0.8112816386108553 1.0 P21281,P21283,P36543,P38606,P42345,P61421,Q6IAA8,Q96EE3,Q9UI12,Q9Y2Q5,Q9Y5K8 Alpha protein kinase 1 signaling pathway 1 9 0.3007355399531929 0.9561814898792792 1.0 Q15750 Signaling by erbb4 6 36 0.480509042196919 0.9740608669684238 1.0 P16949,P61201,P62993,Q15334,Q92542,Q96J02 Sars cov 1 infection 12 42 0.9629530201342282 0.6016972857464967 1.0 P14314,P17844,P27824,P49840,P49841,P55072,Q10472,Q13724,Q14697,Q8WUX9,Q99570,Q9UQN3 Activation of ras in b cells 0 3 0.0 1.0 1.0 Translation of replicase and assembly of the replication transcription complex 3 13 0.7220475075276012 0.7830437973449951 1.0 Q8WUX9,Q99570,Q9UQN3 Heme signaling 5 36 0.38732356339838225 0.9912317422080795 1.0 O14980,P09601,Q15648,Q86X55,Q96EB6 Regulation of bach1 activity 3 10 1.031926587965397 0.5996338369181741 1.0 P63208,Q13309,Q13616 Sensory perception 23 84 0.9071277517958798 0.6931337875578348 1.0 O00159,O14936,P15311,P20020,P26038,P30419,P35241,P35579,P47755,P47756,P49356,P50579,P52907,P56545,Q00013,Q01082,Q12792,Q13813,Q14651,Q6IBS0,Q6NUM9,Q8TC12,Q9Y2J2 Apoptotic factor mediated response 4 20 0.6014056224899599 0.8812712129159418 1.0 P27361,P28482,Q07021,Q9NR28 Smac xiap regulated apoptotic response 1 8 0.3437455222811291 0.9379623427931464 1.0 Q9NR28 Cytochrome c mediated apoptotic response 3 13 0.7220475075276012 0.7830437973449951 1.0 P27361,P28482,Q9NR28 Activation of caspases through apoptosome mediated cleavage 0 6 0.0 1.0 1.0 Sensory perception of taste 0 4 0.0 1.0 1.0 Formation of apoptosome 3 11 0.9028103044496487 0.6702945765004975 1.0 P27361,P28482,Q9NR28 Release of apoptotic factors from the mitochondria 1 6 0.4813774657305249 0.8756637428026797 1.0 Q9NR28 Traf6 mediated irf7 activation in tlr7 8 or 9 signaling 1 10 0.2672833314759092 0.969051322224564 1.0 P61088 N glycan antennae elongation in the medial trans golgi 2 15 0.37000257267815795 0.9606307441557929 1.0 P04066,Q16706 N glycan antennae elongation 0 8 0.0 1.0 1.0 Reactions specific to the complex n glycan synthesis pathway 2 6 1.2040133779264215 0.5656089450744413 1.0 P04066,Q16706 Termination of o glycan biosynthesis 0 4 0.0 1.0 1.0 Amyloid fiber formation 6 41 0.4115778394412018 0.9914840119915252 1.0 P05067,P16104,P62805,Q92542,Q93008,Q9UJY4 Serine biosynthesis 2 7 0.963076923076923 0.6566171786481523 1.0 O43175,Q9Y617 Gaba receptor activation 4 18 0.6875119525721936 0.8205132217227086 1.0 P04899,P08754,P63096,Q9UBI6 Gaba b receptor activation 4 16 0.8023203926818384 0.7360995100844776 1.0 P04899,P08754,P63096,Q9UBI6 Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members 1 8 0.3437455222811291 0.9379623427931464 1.0 P40763 Activation of noxa and translocation to mitochondria 1 5 0.6018054162487463 0.8239879431862632 1.0 P04637 Recognition and association of dna glycosylase with site containing an affected purine 4 16 0.8023203926818384 0.7360995100844776 1.0 P16104,P29372,P62805,Q9NYB0 Antigen activates b cell receptor bcr leading to generation of second messengers 2 20 0.2670382757339279 0.9911014099285991 1.0 O43865,P62993 Opioid signalling 17 63 0.8891925465838509 0.7045952903528545 1.0 O43865,P04899,P08754,P10644,P13861,P17612,P28482,P30153,P30154,P52292,P62136,P63096,Q00535,Q08209,Q13555,Q14738,Q9UBI6 Pka mediated phosphorylation of creb 3 13 0.7220475075276012 0.7830437973449951 1.0 P10644,P13861,P17612 Camk iv mediated phosphorylation of creb 2 8 0.8024526198439242 0.7316356285104274 1.0 P52292,Q13555 Flt3 signaling by cbl mutants 1 4 0.8025186671124485 0.7508451551458319 1.0 P22681 Gpvi mediated activation cascade 5 21 0.7520087043856712 0.7833805412598392 1.0 P60953,P61586,P63000,P84095,Q06124 Maturation of sars cov 1 nucleoprotein 2 9 0.6877209746774964 0.7922091662556401 1.0 P49840,P49841 Maturation of protein 3a 1 5 0.6018054162487463 0.8239879431862632 1.0 Q10472 Effects of pip2 hydrolysis 3 17 0.515461453902404 0.9142722919386125 1.0 Q8N2K0,Q8NCG7,Q9BV23 Transcriptional regulation of testis differentiation 0 4 0.0 1.0 1.0 Defective ripk1 mediated regulated necrosis 1 6 0.4813774657305249 0.8756637428026797 1.0 Q13546 Sos mediated signalling 1 7 0.401092165385044 0.9121715035098086 1.0 P62993 Mapk1 erk2 activation 2 7 0.963076923076923 0.6566171786481523 1.0 P28482,Q06124 Attachment and entry 1 4 0.8025186671124485 0.7508451551458319 1.0 P55072 Irs mediated signalling 4 26 0.4370208105147864 0.9697599170039233 1.0 P31751,P62993,Q06124,Q99570 Neuronal system 48 177 0.894211324570273 0.7686030767969322 1.0 O14936,O43491,O75915,O75955,O94925,O94973,O95197,O95782,P04350,P04899,P05091,P07196,P08754,P10586,P10644,P11142,P11171,P13861,P17612,P21964,P27361,P28482,P41440,P46459,P51649,P51812,P52292,P53680,P54619,P63000,P63010,P63096,P68371,Q13555,Q13885,Q14168,Q14254,Q15334,Q15418,Q96CW1,Q96HC4,Q9BUF5,Q9BVA1,Q9HCM4,Q9UBI6,Q9UJU6,Q9UM54,Q9Y2J2 Foxo mediated transcription of cell death genes 0 12 0.0 1.0 1.0 Transmission across chemical synapses 37 139 0.8718157990776683 0.7881227078684553 1.0 O14936,O75915,O94925,O94973,O95782,P04350,P04899,P05091,P07196,P08754,P10644,P11142,P13861,P17612,P21964,P27361,P28482,P46459,P51649,P51812,P52292,P53680,P54619,P63000,P63010,P63096,P68371,Q13555,Q13885,Q14168,Q15334,Q15418,Q96CW1,Q9BUF5,Q9BVA1,Q9UBI6,Q9UM54 Neurotransmitter release cycle 5 30 0.4806829594911282 0.9645851332924127 1.0 O14936,O75915,O94925,P11142,P51649 Presynaptic depolarization and calcium channel opening 0 4 0.0 1.0 1.0 Electric transmission across gap junctions 0 2 0.0 1.0 1.0 G protein mediated events 10 40 0.8019226469930695 0.7788895119119675 1.0 O43865,P04899,P08754,P10644,P13861,P17612,P28482,P52292,P63096,Q13555 Stat5 activation downstream of flt3 itd mutants 2 6 1.2040133779264215 0.5656089450744413 1.0 P62993,Q06124 Signaling by flt3 fusion proteins 5 16 1.0945917156161549 0.5270800523063662 1.0 P62993,Q01082,Q14789,Q92614,Q9UBW7 Signaling by flt3 itd and tkd mutants 2 12 0.4812040133779264 0.9075099812904823 1.0 P62993,Q06124 Inactivation of csf3 g csf signaling 5 17 1.0032362459546926 0.5884307536605788 1.0 P40763,P42224,Q15369,Q15370,Q93034 Ca dependent events 6 26 0.721768251841929 0.8195103866850959 1.0 P10644,P13861,P17612,P28482,P52292,Q13555 Negative regulation of flt3 2 8 0.8024526198439242 0.7316356285104274 1.0 P22681,P41240 Flt3 signaling through src family kinases 0 2 0.0 1.0 1.0 Neurotransmitter receptors and postsynaptic signal transmission 31 105 1.008744306616647 0.5209858326822338 1.0 O14936,O94973,O95782,P04350,P04899,P07196,P08754,P10644,P13861,P17612,P27361,P28482,P46459,P51812,P52292,P53680,P54619,P63000,P63010,P63096,P68371,Q13555,Q13885,Q14168,Q15334,Q15418,Q96CW1,Q9BUF5,Q9BVA1,Q9UBI6,Q9UM54 Downregulation of erbb4 signaling 1 7 0.401092165385044 0.9121715035098086 1.0 Q96J02 Foxo mediated transcription 11 47 0.7347273472734728 0.8555667342928327 1.0 P04179,P27348,P31751,P31946,P61981,P63104,Q13547,Q92769,Q96EB6,Q96ST3,Q9Y3B8 Interleukin 7 signaling 2 13 0.43739738522347216 0.9301401965681808 1.0 P40763,P51532 Extracellular matrix organization 26 131 0.5926660886876666 0.9951283128108788 1.0 O00469,O14936,O15446,O15460,O60568,O75718,P05067,P05556,P07237,P07384,P12814,P13674,P17655,P20810,P23284,P35613,P50454,Q02809,Q03001,Q08722,Q15149,Q32P28,Q8NBJ5,Q92542,Q9Y296,Q9Y624 Degradation of the extracellular matrix 6 56 0.2875016744809109 0.9997912086677236 1.0 O15446,P07384,P17655,P20810,P35613,Q92542 Alpha defensins 0 1 0.0 1.0 1.0 Notch3 activation and transmission of signal to the nucleus 3 18 0.4810304449648712 0.9330241059965461 1.0 P67809,Q92542,Q9Y6A5 Notch3 intracellular domain regulates transcription 3 18 0.4810304449648712 0.9330241059965461 1.0 P42224,Q13573,Q15398 Defensins 0 1 0.0 1.0 1.0 Notch4 intracellular domain regulates transcription 1 15 0.17170559296938434 0.9945637612889205 1.0 Q13573 Notch4 activation and transmission of signal to the nucleus 2 8 0.8024526198439242 0.7316356285104274 1.0 P63104,Q92542 Tlr3 mediated ticam1 dependent programmed cell death 1 5 0.6018054162487463 0.8239879431862632 1.0 Q13546 Ticam1 dependent activation of irf3 irf7 0 10 0.0 1.0 1.0 Ticam1 traf6 dependent induction of tak1 complex 1 10 0.2672833314759092 0.969051322224564 1.0 Q15750 Interleukin 36 pathway 0 1 0.0 1.0 1.0 Noncanonical activation of notch3 2 8 0.8024526198439242 0.7316356285104274 1.0 P67809,Q92542 Collagen degradation 0 21 0.0 1.0 1.0 Regulation of signaling by nodal 0 3 0.0 1.0 1.0 Biosynthesis of epa derived spms 1 3 1.2039451688398528 0.6473218534129999 1.0 P09960 Interleukin 2 signaling 0 5 0.0 1.0 1.0 Regulation of kit signaling 2 12 0.4812040133779264 0.9075099812904823 1.0 P22681,P62993 Signaling by scf kit 6 31 0.5770127260549229 0.9276030862003526 1.0 P22681,P40763,P42224,P62993,P63000,Q06124 Loss of mecp2 binding ability to the ncor smrt complex 1 7 0.401092165385044 0.9121715035098086 1.0 P51608 Regulation of mecp2 expression and activity 9 30 1.0319908050380728 0.537377176470804 1.0 P17612,P42858,P51608,Q13547,Q13555,Q14739,Q92769,Q96ST3,Q9HCE1 Formation of fibrin clot clotting cascade 2 9 0.6877209746774964 0.7922091662556401 1.0 P42785,Q07021 Common pathway of fibrin clot formation 0 5 0.0 1.0 1.0 Collagen formation 13 44 1.009745638826625 0.5452897721452463 1.0 O00469,O15460,O60568,O75718,P07237,P13674,P23284,P50454,Q02809,Q03001,Q15149,Q32P28,Q8NBJ5 Reversible hydration of carbon dioxide 0 2 0.0 1.0 1.0 Acyl chain remodelling of pc 1 9 0.3007355399531929 0.9561814898792792 1.0 Q8NF37 Acyl chain remodelling of ps 1 9 0.3007355399531929 0.9561814898792792 1.0 Q9BZF1 Metabolism of cofactors 4 15 0.8753803091152489 0.6838446456385155 1.0 O75874,P00374,P07900,P35270 Triglyceride metabolism 6 20 1.0319586642426561 0.5583681068930001 1.0 O60664,P17612,P43304,P62136,P62140,Q9HCL2 Synthesis of pe 2 12 0.4812040133779264 0.9075099812904823 1.0 P35790,Q9UG56 Interleukin 15 signaling 2 8 0.8024526198439242 0.7316356285104274 1.0 P40763,P62993 Interleukin 35 signalling 3 9 1.2040816326530612 0.5196282464541333 1.0 P27824,P40763,P42224 Transcriptional regulation by mecp2 13 45 0.9780547163477677 0.5829215706476896 1.0 P17612,P18031,P42858,P51608,Q13451,Q13547,Q13555,Q14739,Q8WYQ5,Q92769,Q96ST3,Q9HCE1,Q9NWH9 Signaling by ntrk2 trkb 5 18 0.9259354639334553 0.6451159513320872 1.0 P19174,P62993,P63000,Q00535,Q06124 Signaling by erythropoietin 3 19 0.45090331214452994 0.9479246404767652 1.0 P19174,P46109,P62993 Synthesis of pc 5 22 0.7076744323440792 0.8188911287130645 1.0 P19784,P35790,P67870,Q8NF37,Q9NQZ5 Synthesis of pa 7 25 0.9361995160990136 0.6329105152499283 1.0 O15228,P43304,Q8NF37,Q99943,Q9HCL2,Q9NPH0,Q9NUQ2 Synthesis of pg 2 8 0.8024526198439242 0.7316356285104274 1.0 O95674,Q8IV08 Mecp2 regulates transcription factors 1 4 0.8025186671124485 0.7508451551458319 1.0 P51608 Signaling by tgfb family members 20 79 0.8149508406140931 0.8187609460323371 1.0 O14980,P09874,P22681,P27361,P28482,P50750,P61081,P61586,P62136,P62140,P62942,Q13547,Q13573,Q7Z3T8,Q93008,Q9UNE7,Q9UPN9,Q9Y3F4,Q9Y5K5,Q9Y624 Extra nuclear estrogen signaling 12 47 0.8248130393096836 0.765806154020295 1.0 O14980,O43815,P04792,P04899,P07900,P08754,P27361,P28482,P31751,P63096,Q99873,Q9UBI6 Er quality control compartment erqc 2 18 0.30050167224080265 0.9837457247494442 1.0 Q9NYU2,Q9UBV2 Calnexin calreticulin cycle 7 23 1.0535175879396985 0.5326719776995769 1.0 P14314,P27797,P27824,P30101,Q14697,Q9NYU2,Q9UBV2 Hydrolysis of lpc 1 3 1.2039451688398528 0.6473218534129999 1.0 Q8NCC3 Robo receptors bind akap5 2 8 0.8024526198439242 0.7316356285104274 1.0 P13861,P17612 Signaling by notch3 6 35 0.4971476083793334 0.9679044861586501 1.0 P42224,P67809,Q13573,Q15398,Q92542,Q9Y6A5 Acyl chain remodelling of pg 2 7 0.963076923076923 0.6566171786481523 1.0 Q8NF37,Q92604 Acyl chain remodelling of pi 1 4 0.8025186671124485 0.7508451551458319 1.0 Q96N66 Cdc42 gtpase cycle 28 134 0.6325719960278053 0.9898866116721688 1.0 A4D1P6,O00161,O15498,P02786,P14923,P27105,P42166,P42167,P46940,P51149,P52565,P60953,P63167,Q07960,Q13177,Q13576,Q14160,Q14344,Q14739,Q16512,Q68EM7,Q6IAA8,Q86UP2,Q8TAA9,Q96N67,Q9H0H5,Q9NSV4,Q9UQB8 Acyl chain remodeling of dag and tag 0 2 0.0 1.0 1.0 Acyl chain remodelling of pe 0 8 0.0 1.0 1.0 Interleukin 37 signaling 2 12 0.4812040133779264 0.9075099812904823 1.0 P40763,Q06124 G beta gamma signalling through cdc42 3 14 0.6563155813741294 0.8262352177182655 1.0 P60953,Q16512,Q9UBI6 Nr1h2 and nr1h3 mediated signaling 5 31 0.46213077180603124 0.9716970654300356 1.0 O00767,O60341,P49327,Q8NB78,Q9HCE1 Erythropoietin activates phosphoinositide 3 kinase pi3k 0 8 0.0 1.0 1.0 Traf6 mediated irf7 activation 2 15 0.37000257267815795 0.9606307441557929 1.0 Q14258,Q7Z434 Traf6 mediated nf kb activation 5 22 0.7076744323440792 0.8188911287130645 1.0 O15111,P05067,P09429,Q14258,Q7Z434 Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10 4 13 1.0702067529376766 0.5588754825262198 1.0 O15111,Q13546,Q14258,Q7Z434 Negative regulators of ddx58 ifih1 signaling 6 29 0.6273624741547511 0.894060359590428 1.0 P61086,Q13526,Q14258,Q15366,Q7Z434,Q96J02 Ion transport by p type atpases 9 31 0.984944991314418 0.5827692698138716 1.0 P05023,P05026,P16615,P20020,P30626,P54709,P98194,Q13555,Q9HD20 Activation of irf3 irf7 mediated by tbk1 ikk epsilon 1 11 0.24052156469408226 0.9781420785502122 1.0 Q06124 Irak1 recruits ikk complex 2 12 0.4812040133779264 0.9075099812904823 1.0 O15111,P61088 Ikk complex recruitment mediated by rip1 3 16 0.5551895411380189 0.8908482493424653 1.0 O15111,P61088,Q13546 Irak2 mediated activation of tak1 complex 1 9 0.3007355399531929 0.9561814898792792 1.0 Q15750 Traf6 mediated induction of tak1 complex within tlr4 complex 1 11 0.24052156469408226 0.9781420785502122 1.0 Q15750 Molybdenum cofactor biosynthesis 2 7 0.963076923076923 0.6566171786481523 1.0 Q9NQX3,Q9Y697 Transcription of e2f targets under negative control by dream complex 3 19 0.45090331214452994 0.9479246404767652 1.0 P11388,P12004,Q13547 Activated ntrk3 signals through pi3k 0 4 0.0 1.0 1.0 Downregulation of erbb2 erbb3 signaling 1 10 0.2672833314759092 0.969051322224564 1.0 P31751 Grb7 events in erbb2 signaling 0 2 0.0 1.0 1.0 Diseases of base excision repair 0 4 0.0 1.0 1.0 Flt3 signaling 5 27 0.5464588976473811 0.9322710956586475 1.0 P22681,P31751,P41240,P62993,Q06124 Acrosome reaction and sperm oocyte membrane binding 0 1 0.0 1.0 1.0 Sperm motility and taxes 0 1 0.0 1.0 1.0 Tandem pore domain potassium channels 0 2 0.0 1.0 1.0 Voltage gated potassium channels 0 2 0.0 1.0 1.0 Potassium channels 1 15 0.17170559296938434 0.9945637612889205 1.0 Q9UBI6 Inwardly rectifying k channels 1 12 0.21862557369076926 0.9845631783003477 1.0 Q9UBI6 Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1 2 16 0.3435260391782131 0.9705996719890695 1.0 P06493,Q13547 Traf3 dependent irf activation pathway 2 13 0.43739738522347216 0.9301401965681808 1.0 Q14258,Q7Z434 Rora activates gene expression 3 17 0.515461453902404 0.9142722919386125 1.0 P50416,Q15648,Q86X55 Bmal1 clock npas2 activates circadian gene expression 3 20 0.42432054789128765 0.9596870100427658 1.0 P43490,Q15648,Q86X55 Erythropoietin activates phospholipase c gamma plcg 1 5 0.6018054162487463 0.8239879431862632 1.0 P19174 Erythropoietin activates stat5 0 4 0.0 1.0 1.0 Erythropoietin activates ras 2 11 0.5347454477889261 0.8781437590361336 1.0 P46109,P62993 Activated ntrk2 signals through pi3k 1 4 0.8025186671124485 0.7508451551458319 1.0 P62993 Activated ntrk2 signals through frs2 and frs3 2 7 0.963076923076923 0.6566171786481523 1.0 P62993,Q06124 Nr1h2 nr1h3 regulate gene expression linked to lipogenesis 2 7 0.963076923076923 0.6566171786481523 1.0 O00767,P49327 Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux 3 26 0.31336640144297206 0.9919433614038574 1.0 O60341,Q8NB78,Q9HCE1 Nr1h2 nr1h3 regulate gene expression to limit cholesterol uptake 0 3 0.0 1.0 1.0 Nr1h2 nr1h3 regulate gene expression linked to triglyceride lipolysis in adipose 0 3 0.0 1.0 1.0 Ngf stimulated transcription 3 22 0.37954957651740595 0.9761225818261173 1.0 P50570,Q00535,Q14839 Activated ntrk2 signals through fyn 1 4 0.8025186671124485 0.7508451551458319 1.0 P63000 Activated ntrk2 signals through ras 1 6 0.4813774657305249 0.8756637428026797 1.0 P62993 Ntrk2 activates rac1 1 3 1.2039451688398528 0.6473218534129999 1.0 P63000 Extrinsic pathway of fibrin clot formation 0 1 0.0 1.0 1.0 Caspase activation via death receptors in the presence of ligand 2 11 0.5347454477889261 0.8781437590361336 1.0 P49327,Q13546 Blood group systems biosynthesis 0 5 0.0 1.0 1.0 Signaling by ntrk3 trkc 3 15 0.6015389762462362 0.8618328607283439 1.0 P19174,P62993,Q8WX92 Activated ntrk3 signals through ras 1 6 0.4813774657305249 0.8756637428026797 1.0 P62993 Activation of puma and translocation to mitochondria 1 8 0.3437455222811291 0.9379623427931464 1.0 P04637 Elevation of cytosolic ca2 levels 0 6 0.0 1.0 1.0 Interleukin receptor shc signaling 1 14 0.1849394336856724 0.9923015601562292 1.0 P62993 Regulation of signaling by cbl 4 18 0.6875119525721936 0.8205132217227086 1.0 P22681,P46108,P46109,P62993 Abc transporters in lipid homeostasis 2 7 0.963076923076923 0.6566171786481523 1.0 P28288,P40855 O linked glycosylation of mucins 3 22 0.37954957651740595 0.9761225818261173 1.0 O43505,Q10471,Q10472 Intrinsic pathway of fibrin clot formation 2 7 0.963076923076923 0.6566171786481523 1.0 P42785,Q07021 Synthesis of pyrophosphates in the cytosol 1 10 0.2672833314759092 0.969051322224564 1.0 Q9BW91 Pre notch processing in golgi 3 13 0.7220475075276012 0.7830437973449951 1.0 P16615,Q15363,Q9UBV2 Rna polymerase iii chain elongation 5 19 0.8596776507723947 0.6966080955472779 1.0 O14802,O15160,P19388,P62875,Q9BUI4 Interleukin 2 family signaling 3 21 0.40069142411062786 0.9689174597054394 1.0 P40763,P42224,P62993 Transcriptional regulation of pluripotent stem cells 1 16 0.16023626434860136 0.9961613672451205 1.0 P40763 Scavenging by class a receptors 3 10 1.031926587965397 0.5996338369181741 1.0 P14625,P27797,Q5KU26 Scavenging by class b receptors 1 2 2.4082246740220663 0.5008051893494083 1.0 Q8WTV0 Ecm proteoglycans 2 37 0.1370090778786431 0.9999580704399798 1.0 P05067,P05556 Thrombin signalling through proteinase activated receptors pars 4 21 0.56595007480904 0.9043043121411438 1.0 P27361,P28482,Q14344,Q9UBI6 Non integrin membrane ecm interactions 4 37 0.2909009776479656 0.9982235301865416 1.0 O14936,P05556,P12814,Q9Y296 Syndecan interactions 4 20 0.6014056224899599 0.8812712129159418 1.0 O14936,P05556,P12814,Q9Y296 Laminin interactions 1 23 0.10914561867420443 0.999664397240253 1.0 P05556 Peptide hormone metabolism 13 43 1.0435492894707397 0.5065548172238039 1.0 O00471,O60645,P33176,P35222,P61009,P67812,Q15005,Q8IYI6,Q8TAG9,Q96A65,Q96HE7,Q96KP1,Q9UPT5 Notch2 activation and transmission of signal to the nucleus 1 16 0.16023626434860136 0.9961613672451205 1.0 Q92542 Disassembly of the destruction complex and recruitment of axin to the membrane 6 24 0.8021879883902657 0.7499274740177471 1.0 P30153,P30154,P35222,P48729,P49841,Q14738 Regulation of fzd by ubiquitination 0 9 0.0 1.0 1.0 Repression of wnt target genes 3 13 0.7220475075276012 0.7830437973449951 1.0 P56545,Q13363,Q13547 Sumoylation of dna methylation proteins 1 16 0.16023626434860136 0.9961613672451205 1.0 P26358 Sumoylation of immune response proteins 0 10 0.0 1.0 1.0 Pou5f1 oct4 sox2 nanog activate genes related to proliferation 1 8 0.3437455222811291 0.9379623427931464 1.0 P40763 Pou5f1 oct4 sox2 nanog repress genes related to differentiation 0 6 0.0 1.0 1.0 Presynaptic function of kainate receptors 1 13 0.2003789145213418 0.9890984267926946 1.0 Q9UBI6 Gpcr ligand binding 9 46 0.5844198204238432 0.952503243291925 1.0 P04083,P05067,P07602,P42892,Q9BYT8,Q9NRV9,Q9NZJ7,Q9UBI6,Q9Y3E5 Defective galnt3 causes hftc 0 1 0.0 1.0 1.0 Defective lfng causes scdo3 0 3 0.0 1.0 1.0 Defective c1galt1c1 causes tnps 0 2 0.0 1.0 1.0 Ionotropic activity of kainate receptors 1 3 1.2039451688398528 0.6473218534129999 1.0 Q15334 Fceri mediated ca 2 mobilization 4 20 0.6014056224899599 0.8812712129159418 1.0 O43865,P19174,P62993,Q08209 Sumo is transferred from e1 to e2 ube2i ubc9 2 7 0.963076923076923 0.6566171786481523 1.0 Q9UBE0,Q9UBT2 Dex h box helicases activate type i ifn and inflammatory cytokines production 2 7 0.963076923076923 0.6566171786481523 1.0 Q08211,Q9H2U1 Type i hemidesmosome assembly 2 9 0.6877209746774964 0.7922091662556401 1.0 Q03001,Q15149 Synthesis of dolichyl phosphate 1 5 0.6018054162487463 0.8239879431862632 1.0 Q86YN1 Trp channels 1 7 0.401092165385044 0.9121715035098086 1.0 Q13546 Chromatin modifying enzymes 58 210 0.9171420370968321 0.7341111273810481 1.0 O00422,O14497,O14744,O14929,O15047,O15294,O60341,O60678,O94776,O95163,O95251,O95983,O96019,O96028,P11802,P15880,P16104,P51532,P51610,P61964,P62805,Q03164,Q12824,Q13330,Q13547,Q14839,Q15022,Q15047,Q15291,Q15393,Q6IA86,Q7LBC6,Q86U86,Q86X55,Q86YP4,Q8NB78,Q8TAQ2,Q8WXI9,Q92769,Q92922,Q969G3,Q96GM5,Q96KQ7,Q96L73,Q96L91,Q99873,Q9BQA1,Q9H7B4,Q9H9T3,Q9NPF5,Q9UBL3,Q9UBU8,Q9UKL0,Q9Y230,Q9Y265,Q9Y2K7,Q9Y4A5,Q9Y6J9 Sumoylation of transcription factors 3 18 0.4810304449648712 0.9330241059965461 1.0 P04637,Q12888,Q13330 Glycogen storage diseases 3 10 1.031926587965397 0.5996338369181741 1.0 P10253,P13807,P46976 Regulation of cytoskeletal remodeling and cell spreading by ipp complex components 2 7 0.963076923076923 0.6566171786481523 1.0 P12814,Q15404 Processing and activation of sumo 2 10 0.6016722408026756 0.8403529985689939 1.0 Q9UBE0,Q9UBT2 Cell junction organization 16 54 1.0138653084323712 0.5331286709490815 1.0 O60716,P05556,P12814,P14923,P19022,P21333,P35221,P35222,P55196,Q03001,Q13418,Q14315,Q15149,Q15404,Q96AC1,Q9Y624 Nrcam interactions 1 7 0.401092165385044 0.9121715035098086 1.0 Q15334 Chl1 interactions 2 7 0.963076923076923 0.6566171786481523 1.0 P05556,P11142 Neurofascin interactions 1 6 0.4813774657305249 0.8756637428026797 1.0 O00560 Hats acetylate histones 18 90 0.5995292535305985 0.9837137935800414 1.0 O14929,O15294,O95163,O95251,O96019,P51610,P61964,P62805,Q15393,Q6IA86,Q96L91,Q9H9T3,Q9NPF5,Q9UBU8,Q9Y230,Q9Y265,Q9Y4A5,Q9Y6J9 Interleukin 17 signaling 16 57 0.9392866509310255 0.6329578989953143 1.0 O15111,P27361,P28482,P30153,P30154,P51452,P51812,P61088,P63208,Q02750,Q13616,Q14738,Q15418,Q15750,Q16539,Q8IV63 Interleukin 1 processing 0 3 0.0 1.0 1.0 Hdms demethylate histones 5 25 0.6012721794442585 0.8979888857555822 1.0 O60341,P62805,Q7LBC6,Q8NB78,Q9Y2K7 Other interleukin signaling 2 12 0.4812040133779264 0.9075099812904823 1.0 P40222,Q12846 Pkmts methylate histone lysines 12 46 0.8491906829846032 0.7372175012589298 1.0 O15047,O96028,P61964,P62805,Q03164,Q15022,Q15047,Q15291,Q96KQ7,Q96L73,Q9H7B4,Q9UBL3 Activated tak1 mediates p38 mapk activation 3 20 0.42432054789128765 0.9596870100427658 1.0 P61088,Q15750,Q16539 Jnk c jun kinases phosphorylation and activation mediated by activated human tak1 2 18 0.30050167224080265 0.9837457247494442 1.0 P61088,Q15750 Hdacs deacetylate histones 12 40 1.0320230105465005 0.5233766293220338 1.0 O00422,O60341,O94776,O95983,P62805,Q13330,Q13547,Q14839,Q86YP4,Q8WXI9,Q92769,Q9UKL0 Regulation of innate immune responses to cytosolic dna 3 11 0.9028103044496487 0.6702945765004975 1.0 P19474,Q9NZI8,Q9UJV9 Lrr flii interacting protein 1 lrrfip1 activates type i ifn production 1 5 0.6018054162487463 0.8239879431862632 1.0 P35222 Sumo is proteolytically processed 0 6 0.0 1.0 1.0 Interleukin 3 interleukin 5 and gm csf signaling 7 31 0.7015633724176438 0.8481020736427258 1.0 P17612,P22681,P46108,P46109,P62993,P63104,Q06124 Fceri mediated mapk activation 7 24 0.9914080204946301 0.5842864352535018 1.0 P19174,P27361,P28482,P62993,P63000,Q13177,Q16512 O linked glycosylation 3 35 0.22494981599197056 0.9993895721065365 1.0 O43505,Q10471,Q10472 Release of hh np from the secreting cell 0 2 0.0 1.0 1.0 Ra biosynthesis pathway 3 9 1.2040816326530612 0.5196282464541333 1.0 Q8NBN7,Q8TC12,Q9HBH5 Negative regulation of tcf dependent signaling by dvl interacting proteins 0 5 0.0 1.0 1.0 The canonical retinoid cycle in rods twilight vision 1 4 0.8025186671124485 0.7508451551458319 1.0 Q8TC12 Retinoid cycle disease events 0 2 0.0 1.0 1.0 Organic cation transport 0 3 0.0 1.0 1.0 Organic cation anion zwitterion transport 0 3 0.0 1.0 1.0 Shc related events triggered by igf1r 1 7 0.401092165385044 0.9121715035098086 1.0 P62993 Phase 4 resting membrane potential 0 2 0.0 1.0 1.0 Phase 3 rapid repolarisation 0 1 0.0 1.0 1.0 Cardiac conduction 10 43 0.7287157287157288 0.8530791174053061 1.0 O43865,P05023,P05026,P16615,P17612,P20020,P30626,P54709,Q12797,Q13555 Phase 0 rapid depolarisation 1 6 0.4813774657305249 0.8756637428026797 1.0 Q13555 Phase 2 plateau phase 0 3 0.0 1.0 1.0 Dap12 signaling 3 19 0.45090331214452994 0.9479246404767652 1.0 P19174,P62993,P63000 Physiological factors 0 6 0.0 1.0 1.0 Metabolism of ingested semet sec mesec into h2se 1 4 0.8025186671124485 0.7508451551458319 1.0 P23526 Ikba variant leads to eda id 1 7 0.401092165385044 0.9121715035098086 1.0 O15111 Irak4 deficiency tlr2 4 1 4 0.8025186671124485 0.7508451551458319 1.0 P09429 Signaling by type 1 insulin like growth factor 1 receptor igf1r 5 29 0.50078116281665 0.9558569099906208 1.0 O14654,P31751,P62993,Q06124,Q99570 Clec7a dectin 1 induces nfat activation 2 10 0.6016722408026756 0.8403529985689939 1.0 O43865,Q08209 Crosslinking of collagen fibrils 0 10 0.0 1.0 1.0 Constitutive signaling by aberrant pi3k in cancer 6 32 0.5547426451646144 0.9405601659729861 1.0 O43815,P62993,P63000,P84095,Q06124,Q9NWH9 Pi3k akt signaling in cancer 12 58 0.6266121972570762 0.9489703666753901 1.0 O15111,O43815,P31751,P42345,P49840,P49841,P62993,P63000,P84095,Q06124,Q96B36,Q9NWH9 Activation of the phototransduction cascade 0 2 0.0 1.0 1.0 The phototransduction cascade 3 12 0.8023865283818445 0.7313126477609548 1.0 P30419,P49356,P50579 Interaction with cumulus cells and the zona pellucida 0 1 0.0 1.0 1.0 Oxidative stress induced senescence 10 69 0.40610897020541326 0.9988154383810153 1.0 P04637,P11802,P16104,P27361,P28482,P62805,Q00534,Q15022,Q16539,Q9HCE1 O glycosylation of tsr domain containing proteins 0 5 0.0 1.0 1.0 Role of lat2 ntal lab on calcium mobilization 1 12 0.21862557369076926 0.9845631783003477 1.0 P62993 Signaling by notch1 hd domain mutants in cancer 0 9 0.0 1.0 1.0 Uptake and function of anthrax toxins 2 10 0.6016722408026756 0.8403529985689939 1.0 Q02750,Q8WUM4 Stimuli sensing channels 9 38 0.7464713838186505 0.8273697555402955 1.0 P27105,P30626,P51790,P51798,Q12797,Q13546,Q4KMQ2,Q9C0H2,Q9H4A3 Signaling by notch1 t 7 9 notch1 m1580 k2555 translocation mutant 0 4 0.0 1.0 1.0 Acetylcholine neurotransmitter release cycle 0 11 0.0 1.0 1.0 Vegfr2 mediated cell proliferation 2 15 0.37000257267815795 0.9606307441557929 1.0 O43865,P19174 Signaling by notch1 pest domain mutants in cancer 6 45 0.3691586377453759 0.996678906410292 1.0 P63208,Q13547,Q13573,Q13616,Q92542,Q92769 Signaling by leptin 2 8 0.8024526198439242 0.7316356285104274 1.0 P40763,Q06124 Toxicity of botulinum toxin type d botd 0 3 0.0 1.0 1.0 Tak1 activates nfkb by phosphorylation and activation of ikks complex 5 25 0.6012721794442585 0.8979888857555822 1.0 O15111,P05067,P09429,P61088,Q15750 Myogenesis 6 22 0.9027126590756865 0.6626445438959574 1.0 O60271,P19022,P35221,P35222,P60953,Q16539 Trif mediated programmed cell death 1 4 0.8025186671124485 0.7508451551458319 1.0 Q13546 Dna methylation 4 14 0.9630522088353414 0.624675255970463 1.0 P16104,P26358,P62805,Q96T88 Oncogene induced senescence 6 30 0.601138647019424 0.9122157934436538 1.0 P04637,P11802,P27361,P28482,Q00534,Q9HCE1 Uptake and actions of bacterial toxins 6 23 0.8494937157716402 0.7085172143039323 1.0 P07900,P08238,P13639,Q02750,Q16881,Q8WUM4 Signaling by lrp5 mutants 0 2 0.0 1.0 1.0 Signaling by rnf43 mutants 0 4 0.0 1.0 1.0 Caspase activation via extrinsic apoptotic signalling pathway 2 18 0.30050167224080265 0.9837457247494442 1.0 P49327,Q13546 Tnfr1 induced proapoptotic signaling 1 13 0.2003789145213418 0.9890984267926946 1.0 Q13546 Cellular senescence 35 131 0.8763809040694397 0.7750523950312892 1.0 O60934,P04637,P07305,P10412,P11802,P16104,P16402,P16403,P17096,P20700,P24941,P27361,P28482,P30260,P40763,P49959,P51812,P62805,Q00534,Q15022,Q15418,Q16539,Q16763,Q92878,Q96DE5,Q96KQ7,Q96L91,Q9H1A4,Q9HCE1,Q9NYB0,Q9UJX2,Q9UJX3,Q9UJX4,Q9UJX5,Q9UJX6 Regulation of tnfr1 signaling 3 31 0.2572288868709076 0.9980416138790038 1.0 O15111,P63244,Q13546 Tnfr1 induced nfkappab signaling pathway 4 28 0.40049085229808123 0.9814592752917354 1.0 O15111,P63244,Q13546,Q15750 Diseases of immune system 2 15 0.37000257267815795 0.9606307441557929 1.0 O15111,P09429 Aquaporin mediated transport 5 26 0.5725604604077988 0.9166742426731277 1.0 P10644,P13861,P17612,Q99797,Q9UBI6 Defects in cobalamin b12 metabolism 3 10 1.031926587965397 0.5996338369181741 1.0 P22033,Q96EY8,Q99707 Loss of function of smad2 3 in cancer 0 7 0.0 1.0 1.0 Circadian clock 10 55 0.5334972799761533 0.9798097469951248 1.0 P43490,P50416,P62136,P62140,P63208,Q13616,Q15648,Q86X55,Q96EB6,Q9BWF3 Free fatty acids regulate insulin secretion 2 8 0.8024526198439242 0.7316356285104274 1.0 O60488,O95573 Incretin synthesis secretion and inactivation 4 14 0.9630522088353414 0.624675255970463 1.0 P35222,P61009,P67812,Q15005 Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip 3 9 1.2040816326530612 0.5196282464541333 1.0 P61009,P67812,Q15005 Diseases associated with n glycosylation of proteins 4 18 0.6875119525721936 0.8205132217227086 1.0 O75340,Q13724,Q2TAA5,Q9BT22 Sialic acid metabolism 4 16 0.8023203926818384 0.7360995100844776 1.0 P10619,P16278,Q8NFW8,Q9NR45 Negative regulation of tcf dependent signaling by wnt ligand antagonists 0 5 0.0 1.0 1.0 Ca2 pathway 4 45 0.23387860384627943 0.9998083129639072 1.0 P35222,Q08209,Q9HCE1,Q9UBI6 Deactivation of the beta catenin transactivating complex 9 36 0.8019890490557604 0.771897309757236 1.0 O14980,P31751,P35222,P63104,Q13363,Q13547,Q15291,Q9HCK8,Q9UBL3 Sumoylation of intracellular receptors 0 18 0.0 1.0 1.0 G alpha q signalling events 11 66 0.47963770546796375 0.9942471392018339 1.0 P04083,P05067,P27361,P28482,P51812,P62993,Q15418,Q8N2K0,Q8NCG7,Q9BV23,Q9UBI6 G alpha 12 13 signalling events 7 57 0.33553098827470684 0.9993820666408271 1.0 O75116,P61586,Q13464,Q14344,Q92888,Q92974,Q9UBI6 Dscam interactions 3 9 1.2040816326530612 0.5196282464541333 1.0 P63000,Q16512,Q16539 Other semaphorin interactions 1 7 0.401092165385044 0.9121715035098086 1.0 P05556 Ncam signaling for neurite out growth 6 34 0.5149746435747775 0.9604315162740189 1.0 O15020,P27361,P28482,P62993,Q01082,Q13813 P2y receptors 0 1 0.0 1.0 1.0 Nucleotide like purinergic receptors 0 1 0.0 1.0 1.0 Platelet homeostasis 9 51 0.5144868540778699 0.9811721113644607 1.0 P16615,P20020,P30153,P30154,P30626,Q06124,Q14738,Q16539,Q9UBI6 Platelet calcium homeostasis 3 13 0.7220475075276012 0.7830437973449951 1.0 P16615,P20020,P30626 Cgmp effects 0 7 0.0 1.0 1.0 G alpha s signalling events 5 37 0.3751673920321393 0.993125914934019 1.0 P04899,P08754,P63096,Q9UBI6,Q9Y3E5 Adp signalling through p2y purinoceptor 1 2 17 0.32057971014492753 0.9781099893195382 1.0 Q16539,Q9UBI6 G alpha i signalling events 22 88 0.8011223344556678 0.8455379481791604 1.0 O43865,P04083,P04899,P05067,P07602,P08754,P10644,P13861,P17612,P28482,P30153,P30154,P52292,P62136,P63096,Q00535,Q08209,Q13555,Q14738,Q9NRV9,Q9NZJ7,Q9UBI6 Regulation of lipid metabolism by pparalpha 18 95 0.5602057659892226 0.9926290581272 1.0 O60244,O75448,P11310,P23786,P33121,P37268,P48163,P50416,Q01581,Q15067,Q15648,Q16881,Q86X55,Q96ST3,Q9NPJ6,Q9ULK4,Q9Y2W1,Q9Y2X0 Adrenaline noradrenaline inhibits insulin secretion 3 16 0.5551895411380189 0.8908482493424653 1.0 P04899,P63096,Q9UBI6 Acetylcholine regulates insulin secretion 1 8 0.3437455222811291 0.9379623427931464 1.0 P29966 Diseases of glycosylation 16 76 0.6401433691756272 0.9609405900706505 1.0 O43505,O60762,O75340,P06865,P07686,P10619,P16278,P34949,P36871,P51570,Q06210,Q13724,Q2TAA5,Q8NCH0,Q96L58,Q9BT22 Ctla4 inhibitory signaling 5 17 1.0032362459546926 0.5884307536605788 1.0 P30153,P30154,P31751,Q06124,Q14738 Receptor type tyrosine protein phosphatases 1 11 0.24052156469408226 0.9781420785502122 1.0 P10586 Nuclear receptor transcription pathway 2 29 0.1778025517155952 0.99945679911164 1.0 Q15648,Q9UHY1 Sumoylation of transcription cofactors 8 41 0.5825818506783654 0.9453701614550213 1.0 P06748,P17844,Q13263,Q13363,Q15424,Q92841,Q96ST3,Q99497 Olfactory signaling pathway 0 2 0.0 1.0 1.0 Glucagon like peptide 1 glp1 regulates insulin secretion 5 27 0.5464588976473811 0.9322710956586475 1.0 P10644,P13861,P17612,P46940,Q9UBI6 Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 15 56 0.8802854404089893 0.7103675739760634 1.0 O43852,O76024,P05067,P07237,P14314,P14625,P19022,Q02818,Q07065,Q13217,Q15084,Q15293,Q5JRA6,Q86UP2,Q9BTY2 Transcriptional regulation of white adipocyte differentiation 10 68 0.4131686671754666 0.9985285836115836 1.0 O60244,O75448,P11802,Q14966,Q15648,Q86X55,Q9NPJ6,Q9ULK4,Q9Y2W1,Q9Y2X0 Atf6 atf6 alpha activates chaperone genes 2 6 1.2040133779264215 0.5656089450744413 1.0 P14625,P27797 Diseases associated with o glycosylation of proteins 1 17 0.15020060180541625 0.9972895783561956 1.0 O43505 Atf6 atf6 alpha activates chaperones 2 8 0.8024526198439242 0.7316356285104274 1.0 P14625,P27797 G alpha z signalling events 4 28 0.40049085229808123 0.9814592752917354 1.0 P04899,P08754,P63096,Q9UBI6 Signal regulatory protein family interactions 3 9 1.2040816326530612 0.5196282464541333 1.0 P62993,Q06124,Q08722 Nitric oxide stimulates guanylate cyclase 0 11 0.0 1.0 1.0 Adp signalling through p2y purinoceptor 12 4 13 1.0702067529376766 0.5588754825262198 1.0 P04899,P08754,P63096,Q9UBI6 G beta gamma signalling through pi3kgamma 3 15 0.6015389762462362 0.8618328607283439 1.0 P31751,P61586,Q9UBI6 Rap1 signalling 3 13 0.7220475075276012 0.7830437973449951 1.0 P17612,P31946,P63104 Prostacyclin signalling through prostacyclin receptor 1 12 0.21862557369076926 0.9845631783003477 1.0 Q9UBI6 Chemokine receptors bind chemokines 0 3 0.0 1.0 1.0 Ephrin signaling 4 17 0.7405004633920297 0.7815360505152051 1.0 O00560,P63000,Q13177,Q16512 Eph ephrin mediated repulsion of cells 11 43 0.8270295202952029 0.7576100485909272 1.0 O94973,O95782,P09496,P09497,P53680,P63000,P63010,Q00610,Q15375,Q92542,Q96CW1 G protein beta gamma signalling 5 22 0.7076744323440792 0.8188911287130645 1.0 P31751,P60953,P61586,Q16512,Q9UBI6 Dopamine clearance from the synaptic cleft 1 2 2.4082246740220663 0.5008051893494083 1.0 P21964 Sema3a plexin repulsion signaling by inhibiting integrin adhesion 2 10 0.6016722408026756 0.8403529985689939 1.0 P63000,Q9Y490 Energy dependent regulation of mtor by lkb1 ampk 5 27 0.5464588976473811 0.9322710956586475 1.0 P42345,P54619,Q6IAA8,Q9Y2Q5,Q9Y376 Anchoring fibril formation 0 8 0.0 1.0 1.0 Dcc mediated attractive signaling 2 13 0.43739738522347216 0.9301401965681808 1.0 P60953,P63000 Caspase activation via dependence receptors in the absence of ligand 0 7 0.0 1.0 1.0 Defective chsy1 causes tpbs 0 4 0.0 1.0 1.0 Defective chst14 causes eds musculocontractural type 1 4 0.8025186671124485 0.7508451551458319 1.0 Q8NCH0 Defective chst3 causes sedcjd 0 4 0.0 1.0 1.0 Gp1b ix v activation signalling 2 7 0.963076923076923 0.6566171786481523 1.0 P21333,P63104 Vasopressin regulates renal water homeostasis via aquaporins 4 25 0.45789507235290366 0.9615928901875649 1.0 P10644,P13861,P17612,Q9UBI6 Defective b4galt7 causes eds progeroid type 0 13 0.0 1.0 1.0 Diseases associated with glycosaminoglycan metabolism 4 26 0.4370208105147864 0.9697599170039233 1.0 P06865,P07686,Q8NCH0,Q96L58 Fatty acids bound to gpr40 ffar1 regulate insulin secretion 0 6 0.0 1.0 1.0 Zinc transporters 0 12 0.0 1.0 1.0 Zinc efflux and compartmentalization by the slc30 family 0 5 0.0 1.0 1.0 Grb2 sos provides linkage to mapk signaling for integrins 2 9 0.6877209746774964 0.7922091662556401 1.0 P62993,Q9Y490 Integrin signaling 5 18 0.9259354639334553 0.6451159513320872 1.0 P18031,P41240,P46108,P62993,Q9Y490 Binding of tcf lef ctnnb1 to target gene promoters 1 7 0.401092165385044 0.9121715035098086 1.0 P35222 Amino acid transport across the plasma membrane 3 17 0.515461453902404 0.9142722919386125 1.0 P08195,P30825,Q15758 Zinc influx into cells by the slc39 gene family 0 7 0.0 1.0 1.0 Na cl dependent neurotransmitter transporters 0 4 0.0 1.0 1.0 Creb1 phosphorylation through the activation of adenylate cyclase 3 9 1.2040816326530612 0.5196282464541333 1.0 P10644,P13861,P17612 Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde 2 7 0.963076923076923 0.6566171786481523 1.0 P52292,Q13555 Notch hlh transcription pathway 3 21 0.40069142411062786 0.9689174597054394 1.0 Q13547,Q13573,Q92769 Activation of nmda receptors and postsynaptic events 20 68 1.003252579632122 0.5411079819896368 1.0 O14936,P04350,P07196,P10644,P13861,P17612,P27361,P28482,P51812,P52292,P54619,P63000,P68371,Q13555,Q13885,Q14168,Q15334,Q15418,Q9BUF5,Q9BVA1 Ras activation upon ca2 influx through nmda receptor 4 13 1.0702067529376766 0.5588754825262198 1.0 P07196,Q13555,Q14168,Q15334 Regulation by c flip 2 10 0.6016722408026756 0.8403529985689939 1.0 P49327,Q13546 Signaling by tgf beta receptor complex in cancer 1 8 0.3437455222811291 0.9379623427931464 1.0 P62942 Defective chst6 causes mcdc1 0 1 0.0 1.0 1.0 Thromboxane signalling through tp receptor 3 15 0.6015389762462362 0.8618328607283439 1.0 Q13685,Q14344,Q9UBI6 Defective ext2 causes exostoses 2 0 11 0.0 1.0 1.0 Defective b4galt1 causes b4galt1 cdg cdg 2d 0 1 0.0 1.0 1.0 Role of second messengers in netrin 1 signaling 1 3 1.2039451688398528 0.6473218534129999 1.0 P19174 Ncam1 interactions 0 15 0.0 1.0 1.0 Lysosphingolipid and lpa receptors 0 3 0.0 1.0 1.0 Tight junction interactions 1 11 0.24052156469408226 0.9781420785502122 1.0 Q9Y624 Glucagon type ligand receptors 1 13 0.2003789145213418 0.9890984267926946 1.0 Q9UBI6 Nectin necl trans heterodimerization 0 5 0.0 1.0 1.0 Cell cell junction organization 7 31 0.7015633724176438 0.8481020736427258 1.0 O60716,P14923,P19022,P35221,P35222,P55196,Q9Y624 Netrin 1 signaling 8 33 0.7698659517426274 0.7960496689507663 1.0 O94813,P15311,P19174,P60953,P63000,Q06124,Q16512,Q16539 Regulation of insulin secretion 12 48 0.8017897091722596 0.792170947596045 1.0 O43865,O60488,O95573,P04899,P10644,P11166,P13861,P17612,P29966,P46940,P63096,Q9UBI6 Transport of bile salts and organic acids metal ions and amine compounds 2 32 0.15995540691192864 0.999790784454271 1.0 P35613,P53985 Bicarbonate transporters 1 4 0.8025186671124485 0.7508451551458319 1.0 Q9Y6M7 Netrin mediated repulsion signals 1 5 0.6018054162487463 0.8239879431862632 1.0 Q06124 Transport of inorganic cations anions and amino acids oligopeptides 9 44 0.6179876442699105 0.9328378360580994 1.0 P08195,P30626,P30825,P55011,Q15758,Q70HW3,Q9H936,Q9UBX3,Q9Y6M7 Metal ion slc transporters 0 15 0.0 1.0 1.0 Sodium calcium exchangers 1 3 1.2039451688398528 0.6473218534129999 1.0 P30626 Sodium proton exchangers 0 4 0.0 1.0 1.0 Class b 2 secretin family receptors 2 25 0.20884106441762396 0.9980907494024561 1.0 Q9UBI6,Q9Y3E5 Cation coupled chloride cotransporters 1 4 0.8025186671124485 0.7508451551458319 1.0 P55011 Sirt1 negatively regulates rrna expression 4 18 0.6875119525721936 0.8205132217227086 1.0 O43159,P16104,P62805,Q96EB6 Signaling by gpcr 41 204 0.6001521788392413 0.9990649647357662 1.0 O43865,O75116,P04083,P04899,P05067,P07602,P08754,P10644,P13861,P17612,P27361,P28482,P30153,P30154,P31751,P42892,P51812,P52292,P60953,P61586,P62136,P62993,P63096,Q00535,Q08209,Q13464,Q13555,Q14344,Q14738,Q15418,Q16512,Q8N2K0,Q8NCG7,Q92888,Q92974,Q9BV23,Q9BYT8,Q9NRV9,Q9NZJ7,Q9UBI6,Q9Y3E5 Multifunctional anion exchangers 0 3 0.0 1.0 1.0 Sodium coupled phosphate cotransporters 0 2 0.0 1.0 1.0 P130cas linkage to mapk signaling for integrins 2 9 0.6877209746774964 0.7922091662556401 1.0 P46108,Q9Y490 Regulation of commissural axon pathfinding by slit and robo 1 7 0.401092165385044 0.9121715035098086 1.0 O94813 Slc mediated transmembrane transport 19 101 0.5550687898402697 0.9944865759336281 1.0 P05141,P08195,P11166,P12235,P12236,P30626,P30825,P35613,P36404,P53985,P55011,Q15758,Q6P1M0,Q70HW3,Q8TB61,Q99808,Q9H936,Q9UBX3,Q9Y6M7 Synthesis of ip2 ip and ins in the cytosol 2 12 0.4812040133779264 0.9075099812904823 1.0 Q01968,Q9NPH2 Activation of anterior hox genes in hindbrain development during early embryogenesis 14 60 0.7315385289222414 0.8803171144778819 1.0 O15514,P16104,P19387,P19388,P24928,P30876,P61964,P62487,P62805,P62875,Q15022,Q15291,Q92600,Q9UBL3 Visual phototransduction 5 40 0.34286670811612224 0.9967387252338186 1.0 P30419,P49356,P50579,Q6NUM9,Q8TC12 Tp53 regulates transcription of genes involved in g1 cell cycle arrest 2 13 0.43739738522347216 0.9301401965681808 1.0 P04637,P24941 Formation of the beta catenin tcf transactivating complex 10 38 0.8594423684966944 0.7163451728683593 1.0 P16104,P35222,P51532,P62805,Q13547,Q15291,Q6P1J9,Q9UBL3,Q9Y265,Q9Y4A5 Wnt mediated activation of dvl 2 8 0.8024526198439242 0.7316356285104274 1.0 P19784,P67870 Regulation of tp53 activity through association with co factors 2 12 0.4812040133779264 0.9075099812904823 1.0 P04637,P31751 Regulation of tp53 activity through methylation 4 16 0.8023203926818384 0.7360995100844776 1.0 O14744,O96017,P04637,Q96KQ7 Keratinization 5 24 0.6330061846950822 0.8757671481753739 1.0 P07384,P14923,P15924,Q14126,Q14574 Regulation of tp53 expression and degradation 9 33 0.9026148172980222 0.6667162820541698 1.0 O96017,P04637,P06493,P24941,P30153,P30154,P31751,P42345,Q93009 Metabolism of fat soluble vitamins 3 29 0.27709293048871503 0.9965295982974371 1.0 Q6NUM9,Q8N0U8,Q8TC12 Signaling by met 19 64 1.0167133834136861 0.5232847807123222 1.0 O14964,P05556,P18031,P20338,P22681,P40763,P42566,P46108,P46109,P62330,P62993,P63000,Q06124,Q92783,Q96N67,Q96P70,Q96S59,Q99961,Q9NWH9 Met receptor activation 1 4 0.8025186671124485 0.7508451551458319 1.0 Q9NWH9 Signaling by alk 5 19 0.8596776507723947 0.6966080955472779 1.0 P19174,P40763,Q13547,Q92769,Q96ST3 Signaling by bmp 1 15 0.17170559296938434 0.9945637612889205 1.0 Q7Z3T8 Creb phosphorylation 2 7 0.963076923076923 0.6566171786481523 1.0 P51812,Q15418 Formation of the cornified envelope 5 24 0.6330061846950822 0.8757671481753739 1.0 P07384,P14923,P15924,Q14126,Q14574 Negative regulation of the pi3k akt network 13 62 0.6372156113200568 0.948412681686518 1.0 O43815,P27361,P28482,P30153,P30154,P31751,P62993,P63000,P84095,Q06124,Q14738,Q8TBX8,Q9NWH9 Vitamin b5 pantothenate metabolism 4 13 1.0702067529376766 0.5588754825262198 1.0 P49327,Q13057,Q9NRN7,Q9NVE7 Intra golgi traffic 10 42 0.7515928906773978 0.8308770083779342 1.0 O00461,O15498,O95249,P46459,P54920,P83436,Q13190,Q16706,Q8TBA6,Q99747 Retrograde transport at the trans golgi network 13 49 0.8688970944761478 0.7176802734896238 1.0 O60664,P11717,P20645,P40616,P46459,P51151,P54920,P83436,Q5VIR6,Q5VZE5,Q8IWJ2,Q99747,Q9UID3 Immunoregulatory interactions between a lymphoid and a non lymphoid cell 6 26 0.721768251841929 0.8195103866850959 1.0 P01889,P04439,P05556,P10321,P78310,Q5KU26 Pi5p regulates tp53 acetylation 3 9 1.2040816326530612 0.5196282464541333 1.0 P04637,Q13526,Q8TBX8 Akt phosphorylates targets in the nucleus 1 9 0.3007355399531929 0.9561814898792792 1.0 P31751 Cdc6 association with the orc origin complex 3 12 0.8023865283818445 0.7313126477609548 1.0 O43913,Q9UBD5,Q9Y619 Pi3k akt activation 1 7 0.401092165385044 0.9121715035098086 1.0 P61586 G protein activation 1 13 0.2003789145213418 0.9890984267926946 1.0 Q9UBI6 Signaling by notch2 1 22 0.11435894986546942 0.9995245861479585 1.0 Q92542 Assembly of collagen fibrils and other multimeric structures 2 28 0.18466683817854387 0.9992549231781571 1.0 Q03001,Q15149 Tp53 regulates transcription of caspase activators and caspases 1 8 0.3437455222811291 0.9379623427931464 1.0 P04637 Synthesis of wybutosine at g37 of trna phe 0 6 0.0 1.0 1.0 Fanconi anemia pathway 6 36 0.480509042196919 0.9740608669684238 1.0 P15927,P27694,P35244,Q16658,Q9BXW9,Q9NVI1 Interleukin 10 signaling 1 6 0.4813774657305249 0.8756637428026797 1.0 P40763 Calcineurin activates nfat 2 8 0.8024526198439242 0.7316356285104274 1.0 P62942,Q08209 Erbb2 regulates cell motility 2 6 1.2040133779264215 0.5656089450744413 1.0 O60610,P61586 Interleukin 4 and interleukin 13 signaling 12 40 1.0320230105465005 0.5233766293220338 1.0 P04083,P04637,P05556,P07900,P08670,P09601,P11142,P14625,P40763,P42224,Q07820,Q16658 Cs ds degradation 2 7 0.963076923076923 0.6566171786481523 1.0 P06865,P07686 Gdp fucose biosynthesis 1 6 0.4813774657305249 0.8756637428026797 1.0 Q13630 Il 6 type cytokine receptor ligand interactions 0 6 0.0 1.0 1.0 Hs gag degradation 3 17 0.515461453902404 0.9142722919386125 1.0 P08236,P16278,P54802 Rrna modification in the mitochondrion 1 6 0.4813774657305249 0.8756637428026797 1.0 Q8WVM0 Protein protein interactions at synapses 14 46 1.0536433848220281 0.49088602544338256 1.0 O14936,O43491,O75955,O95197,P10586,P11171,P41440,Q14168,Q14254,Q15334,Q96HC4,Q9HCM4,Q9UJU6,Q9Y2J2 Hs gag biosynthesis 1 17 0.15020060180541625 0.9972895783561956 1.0 Q7LGA3 Choline catabolism 1 4 0.8025186671124485 0.7508451551458319 1.0 P49419 Dermatan sulfate biosynthesis 1 6 0.4813774657305249 0.8756637428026797 1.0 Q8NCH0 Chondroitin sulfate biosynthesis 0 12 0.0 1.0 1.0 Signaling by moderate kinase activity braf mutants 11 36 1.059630996309963 0.4992096541396956 1.0 P18206,P27361,P28482,P30086,P31946,P35232,P41240,P46940,Q02750,Q13555,Q9Y490 Keratan sulfate biosynthesis 1 11 0.24052156469408226 0.9781420785502122 1.0 O43505 Ras signaling downstream of nf1 loss of function variants 0 5 0.0 1.0 1.0 Metabolism of angiotensinogen to angiotensins 0 8 0.0 1.0 1.0 Antimicrobial peptides 2 7 0.963076923076923 0.6566171786481523 1.0 P81605,Q96JM3 Tp53 regulates transcription of genes involved in cytochrome c release 1 16 0.16023626434860136 0.9961613672451205 1.0 P04637 Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain 2 11 0.5347454477889261 0.8781437590361336 1.0 P04637,Q92696 Tp53 regulates transcription of death receptors and ligands 2 10 0.6016722408026756 0.8403529985689939 1.0 P04637,P49327 Signaling by notch1 7 56 0.34242641780330224 0.9992112952789172 1.0 P63208,Q13547,Q13573,Q13616,Q92542,Q92769,Q96J02 Nicotinamide salvaging 3 11 0.9028103044496487 0.6702945765004975 1.0 P43490,Q8NCW5,Q9BQG2 G2 phase 1 4 0.8025186671124485 0.7508451551458319 1.0 P24941 Tryptophan catabolism 2 6 1.2040133779264215 0.5656089450744413 1.0 P08195,Q6YP21 Creatine metabolism 2 6 1.2040133779264215 0.5656089450744413 1.0 P12277,P12532 Fgfr2b ligand binding and activation 0 2 0.0 1.0 1.0 Fgfr2c ligand binding and activation 0 2 0.0 1.0 1.0 Fgfr1c ligand binding and activation 0 2 0.0 1.0 1.0 Fgfr3b ligand binding and activation 0 1 0.0 1.0 1.0 Fgfr1b ligand binding and activation 0 2 0.0 1.0 1.0 Fgfr1 ligand binding and activation 0 2 0.0 1.0 1.0 Fgfr2 ligand binding and activation 0 2 0.0 1.0 1.0 Fgfr3 ligand binding and activation 0 3 0.0 1.0 1.0 Mrna editing c to u conversion 0 2 0.0 1.0 1.0 Cellular hexose transport 1 6 0.4813774657305249 0.8756637428026797 1.0 P11166 Signalling to p38 via rit and rin 0 3 0.0 1.0 1.0 Signalling to erks 9 30 1.0319908050380728 0.537377176470804 1.0 P11233,P27361,P28482,P31946,P46108,P46109,P62993,Q02750,Q16539 Ngf independant trka activation 0 1 0.0 1.0 1.0 Activation of trka receptors 0 1 0.0 1.0 1.0 Signaling by pdgf 7 35 0.6010050251256281 0.9243121618016044 1.0 P19174,P40763,P42224,P46108,P46109,P62993,Q06124 Downstream signal transduction 7 23 1.0535175879396985 0.5326719776995769 1.0 P19174,P40763,P42224,P46108,P46109,P62993,Q06124 Regulation of beta cell development 3 22 0.37954957651740595 0.9761225818261173 1.0 O00330,P31751,Q13573 Transport of nucleotide sugars 1 4 0.8025186671124485 0.7508451551458319 1.0 Q8TB61 Pyrimidine salvage 2 9 0.6877209746774964 0.7922091662556401 1.0 P04183,Q9BZX2 Pyrimidine catabolism 1 6 0.4813774657305249 0.8756637428026797 1.0 Q9H0P0 Synthesis of ip3 and ip4 in the cytosol 2 20 0.2670382757339279 0.9911014099285991 1.0 P19174,Q01968 Histidine catabolism 0 3 0.0 1.0 1.0 Pre notch processing in the endoplasmic reticulum 1 5 0.6018054162487463 0.8239879431862632 1.0 Q9H488 Urea cycle 2 6 1.2040133779264215 0.5656089450744413 1.0 P78540,Q9Y619 Fructose catabolism 0 3 0.0 1.0 1.0 A tetrasaccharide linker sequence is required for gag synthesis 1 16 0.16023626434860136 0.9961613672451205 1.0 Q96L58 Vitamin b2 riboflavin metabolism 1 4 0.8025186671124485 0.7508451551458319 1.0 Q8NFF5 Vitamin b1 thiamin metabolism 1 5 0.6018054162487463 0.8239879431862632 1.0 Q9HC21 Nicotinate metabolism 4 18 0.6875119525721936 0.8205132217227086 1.0 P43490,Q4G0N4,Q8NCW5,Q9BQG2 Coenzyme a biosynthesis 2 8 0.8024526198439242 0.7316356285104274 1.0 Q13057,Q9NVE7 Cobalamin cbl vitamin b12 transport and metabolism 3 13 0.7220475075276012 0.7830437973449951 1.0 P22033,Q96EY8,Q99707 Pi3k events in erbb2 signaling 1 7 0.401092165385044 0.9121715035098086 1.0 P62993 Cyclin d associated events in g1 9 45 0.600737512571237 0.9434173720287171 1.0 P11802,P24941,P30153,P30154,P63151,P63208,Q00534,Q13309,Q13616 Grb2 events in erbb2 signaling 1 7 0.401092165385044 0.9121715035098086 1.0 P62993 Vegf ligand receptor interactions 0 2 0.0 1.0 1.0 Signaling by vegf 26 87 1.0264859666382942 0.49640379765608333 1.0 O43865,O60716,O75116,P04792,P07900,P14923,P17612,P19174,P31751,P35221,P35222,P42345,P46108,P60953,P61586,P63000,Q13177,Q13464,Q13685,Q16512,Q16539,Q7L576,Q96F07,Q96JJ3,Q9UQB8,Q9Y2A7 Trna modification in the nucleus and cytosol 11 43 0.8270295202952029 0.7576100485909272 1.0 O75648,P07814,Q08J23,Q5VV42,Q7Z4G4,Q96PZ0,Q9H974,Q9NPF4,Q9NX74,Q9UJA5,Q9Y606 Bile acid and bile salt metabolism 5 22 0.7076744323440792 0.8188911287130645 1.0 O14734,P22059,P22307,P51659,Q96SU4 Synthesis of bile acids and bile salts via 24 hydroxycholesterol 0 5 0.0 1.0 1.0 P75 ntr receptor mediated signalling 12 81 0.41639918295885614 0.9993098273391525 1.0 P52565,P61586,P62258,P63000,Q13547,Q14344,Q92542,Q92769,Q92888,Q92974,Q9NQC3,Q9NY61 Regulated proteolysis of p75ntr 1 11 0.24052156469408226 0.9781420785502122 1.0 Q92542 Nrage signals death through jnk 5 47 0.2854432700432031 0.9994697994334536 1.0 P63000,Q14344,Q92888,Q92974,Q9NY61 P75ntr signals via nf kb 0 14 0.0 1.0 1.0 Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol 3 13 0.7220475075276012 0.7830437973449951 1.0 O14734,P22307,P51659 Estrogen biosynthesis 1 2 2.4082246740220663 0.5008051893494083 1.0 Q8NBQ5 Androgen biosynthesis 1 2 2.4082246740220663 0.5008051893494083 1.0 Q53GQ0 Synthesis of bile acids and bile salts 5 20 0.8022542126994755 0.7426880917621369 1.0 O14734,P22059,P22307,P51659,Q96SU4 Pre notch expression and processing 9 50 0.527108901662265 0.9772014129056082 1.0 P04637,P16104,P16615,P62805,Q13573,Q15363,Q9H488,Q9HCE1,Q9UBV2 Cd28 dependent pi3k akt signaling 2 15 0.37000257267815795 0.9606307441557929 1.0 P31751,P42345 Synthesis of bile acids and bile salts via 27 hydroxycholesterol 0 7 0.0 1.0 1.0 Cell surface interactions at the vascular wall 14 70 0.6000671591672263 0.9719519872873841 1.0 P05026,P05556,P08195,P14174,P19174,P35613,P53985,P54709,P62993,P78310,Q06124,Q08722,Q92896,Q9Y624 Signaling by hippo 6 21 0.9630274614869391 0.6124722534016208 1.0 P31946,P62258,Q07157,Q13043,Q4VCS5,Q9UDY2 Fcgr activation 0 5 0.0 1.0 1.0 Phospholipase c mediated cascade fgfr4 1 3 1.2039451688398528 0.6473218534129999 1.0 P19174 Downstream signaling of activated fgfr1 3 15 0.6015389762462362 0.8618328607283439 1.0 P19174,P62993,Q06124 Shc mediated cascade fgfr1 1 8 0.3437455222811291 0.9379623427931464 1.0 P62993 Pi 3k cascade fgfr1 2 8 0.8024526198439242 0.7316356285104274 1.0 P62993,Q06124 Frs mediated fgfr1 signaling 2 9 0.6877209746774964 0.7922091662556401 1.0 P62993,Q06124 Pi 3k cascade fgfr2 2 8 0.8024526198439242 0.7316356285104274 1.0 P62993,Q06124 Downstream signaling of activated fgfr2 3 14 0.6563155813741294 0.8262352177182655 1.0 P19174,P62993,Q06124 Frs mediated fgfr2 signaling 2 9 0.6877209746774964 0.7922091662556401 1.0 P62993,Q06124 Shc mediated cascade fgfr3 1 8 0.3437455222811291 0.9379623427931464 1.0 P62993 Frs mediated fgfr3 signaling 2 9 0.6877209746774964 0.7922091662556401 1.0 P62993,Q06124 Downstream signaling of activated fgfr3 3 14 0.6563155813741294 0.8262352177182655 1.0 P19174,P62993,Q06124 Pi 3k cascade fgfr3 2 8 0.8024526198439242 0.7316356285104274 1.0 P62993,Q06124 Frs mediated fgfr4 signaling 2 9 0.6877209746774964 0.7922091662556401 1.0 P62993,Q06124 Downstream signaling of activated fgfr4 3 14 0.6563155813741294 0.8262352177182655 1.0 P19174,P62993,Q06124 Shc mediated cascade fgfr4 1 8 0.3437455222811291 0.9379623427931464 1.0 P62993 Pi 3k cascade fgfr4 2 8 0.8024526198439242 0.7316356285104274 1.0 P62993,Q06124 Signaling by fgfr1 7 28 0.8021217197096594 0.7573372587936686 1.0 P19174,P22681,P27361,P28482,P30153,P62993,Q06124 Ubiquinol biosynthesis 0 7 0.0 1.0 1.0 Signaling by fgfr3 7 27 0.8423450586264657 0.7196284267594591 1.0 P19174,P22681,P27361,P28482,P30153,P62993,Q06124 Signaling by fgfr4 7 26 0.8868024332187252 0.6781129016609558 1.0 P19174,P22681,P27361,P28482,P30153,P62993,Q06124 Synthesis of 15 eicosatetraenoic acid derivatives 0 3 0.0 1.0 1.0 Signaling by fgfr4 in disease 2 11 0.5347454477889261 0.8781437590361336 1.0 P19174,P62993 Synthesis of 12 eicosatetraenoic acid derivatives 0 2 0.0 1.0 1.0 Phospholipase c mediated cascade fgfr2 1 3 1.2039451688398528 0.6473218534129999 1.0 P19174 Synthesis of 16 20 hydroxyeicosatetraenoic acids hete 0 1 0.0 1.0 1.0 Hyaluronan biosynthesis and export 0 1 0.0 1.0 1.0 Gli proteins bind promoters of hh responsive genes to promote transcription 0 2 0.0 1.0 1.0 The retinoid cycle in cones daylight vision 0 1 0.0 1.0 1.0 Egfr transactivation by gastrin 1 7 0.401092165385044 0.9121715035098086 1.0 P62993 Smad2 smad3 smad4 heterotrimer regulates transcription 4 29 0.3844176706827309 0.9855556537572402 1.0 P27361,P28482,P50750,Q13547 Downregulation of smad2 3 smad4 transcriptional activity 5 23 0.6682661905293308 0.8495505493646256 1.0 P09874,Q13547,Q13573,Q93008,Q9UPN9 Transcriptional activity of smad2 smad3 smad4 heterotrimer 8 41 0.5825818506783654 0.9453701614550213 1.0 P09874,P27361,P28482,P50750,Q13547,Q13573,Q93008,Q9UPN9 Tgf beta receptor signaling in emt epithelial to mesenchymal transition 3 14 0.6563155813741294 0.8262352177182655 1.0 P61586,P62942,Q9Y624 Intraflagellar transport 12 48 0.8017897091722596 0.792170947596045 1.0 A0AVF1,P04350,P63167,P68371,Q13885,Q8NCM8,Q92973,Q96FJ2,Q9BUF5,Q9BVA1,Q9BW83,Q9Y496 Pyroptosis 4 16 0.8023203926818384 0.7360995100844776 1.0 P04637,P09429,Q8WUX9,Q9UQN3 Dectin 2 family 0 4 0.0 1.0 1.0 Cd209 dc sign signaling 3 18 0.4810304449648712 0.9330241059965461 1.0 P17612,Q13177,Q16512 Downregulation of tgf beta receptor signaling 6 22 0.9027126590756865 0.6626445438959574 1.0 O14980,P62136,P62140,Q9UNE7,Q9Y3F4,Q9Y5K5 Synthesis of 5 eicosatetraenoic acids 1 3 1.2039451688398528 0.6473218534129999 1.0 Q15165 Dap12 interactions 5 21 0.7520087043856712 0.7833805412598392 1.0 P01889,P10321,P19174,P62993,P63000 Scavenging of heme from plasma 0 2 0.0 1.0 1.0 Abacavir metabolism 1 4 0.8025186671124485 0.7508451551458319 1.0 P49902 Abacavir transport and metabolism 2 6 1.2040133779264215 0.5656089450744413 1.0 P08183,P49902 Tnfr1 mediated ceramide production 1 3 1.2039451688398528 0.6473218534129999 1.0 P63244 Abacavir transmembrane transport 1 2 2.4082246740220663 0.5008051893494083 1.0 P08183 Integrin cell surface interactions 4 37 0.2909009776479656 0.9982235301865416 1.0 P05556,P35613,Q08722,Q9Y624 Activation of ppargc1a pgc 1alpha by phosphorylation 2 8 0.8024526198439242 0.7316356285104274 1.0 P54619,Q16539 Ligand receptor interactions 0 2 0.0 1.0 1.0 Transcriptional activation of mitochondrial biogenesis 12 51 0.7398038203407331 0.8582578855024988 1.0 O00411,P00367,P04179,P06576,P48735,P51610,Q00059,Q04837,Q15648,Q86X55,Q8WVM0,Q96RR1 Tp53 regulates transcription of cell death genes 3 34 0.23223863844850473 0.9991810491268043 1.0 P04637,P49327,Q92696 Activation of smo 2 11 0.5347454477889261 0.8781437590361336 1.0 P48729,Q9Y496 Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3 4 14 0.9630522088353414 0.624675255970463 1.0 O60341,P16104,P62805,Q16512 Notch2 intracellular domain regulates transcription 0 7 0.0 1.0 1.0 Fgfrl1 modulation of fgfr1 signaling 0 2 0.0 1.0 1.0 Clec7a inflammasome pathway 0 4 0.0 1.0 1.0 Regulation of gene expression in early pancreatic precursor cells 1 3 1.2039451688398528 0.6473218534129999 1.0 O00330 Ovarian tumor domain proteases 8 34 0.7401526087853165 0.8241602173122456 1.0 P04637,P06493,P55072,P61586,Q13546,Q14258,Q7Z434,Q96FW1 Cd22 mediated bcr regulation 0 2 0.0 1.0 1.0 Regulation of gene expression in beta cells 2 12 0.4812040133779264 0.9075099812904823 1.0 O00330,P31751 Resolution of d loop structures 7 32 0.6734070351758794 0.8714557404830116 1.0 O60934,P38398,P49959,P51530,P54132,Q92878,Q9UQ84 Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells 1 10 0.2672833314759092 0.969051322224564 1.0 Q13573 Glutamate neurotransmitter release cycle 2 17 0.32057971014492753 0.9781099893195382 1.0 O75915,O94925 Resolution of d loop structures through synthesis dependent strand annealing sdsa 7 26 0.8868024332187252 0.6781129016609558 1.0 O60934,P38398,P49959,P51530,P54132,Q92878,Q9UQ84 Metabolism of amine derived hormones 0 1 0.0 1.0 1.0 Nf kb is activated and signals survival 0 11 0.0 1.0 1.0 P75ntr recruits signalling complexes 0 11 0.0 1.0 1.0 Nrif signals cell death from the nucleus 1 14 0.1849394336856724 0.9923015601562292 1.0 Q92542 Nade modulates death signalling 1 5 0.6018054162487463 0.8239879431862632 1.0 P62258 Cell death signalling via nrage nrif and nade 7 63 0.29932998324958127 0.9998621399102859 1.0 P62258,P63000,Q14344,Q92542,Q92888,Q92974,Q9NY61 Linoleic acid la metabolism 2 7 0.963076923076923 0.6566171786481523 1.0 O95864,P33121 Nostrin mediated enos trafficking 1 3 1.2039451688398528 0.6473218534129999 1.0 P50570 Yap1 and wwtr1 taz stimulated gene expression 0 10 0.0 1.0 1.0 Deposition of new cenpa containing nucleosomes at the centromere 7 34 0.6233513245238539 0.9092825641979646 1.0 O60264,P06748,P16104,P62805,Q92674,Q96T23,Q9Y265 Role of phospholipids in phagocytosis 3 16 0.5551895411380189 0.8908482493424653 1.0 O43865,P19174,Q8IV08 Presynaptic nicotinic acetylcholine receptors 0 2 0.0 1.0 1.0 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors 0 1 0.0 1.0 1.0 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors 0 2 0.0 1.0 1.0 Highly calcium permeable nicotinic acetylcholine receptors 0 2 0.0 1.0 1.0 Josephin domain dubs 2 9 0.6877209746774964 0.7922091662556401 1.0 P54727,P55072 Pecam1 interactions 2 9 0.6877209746774964 0.7922091662556401 1.0 P19174,Q06124 Diseases associated with surfactant metabolism 0 1 0.0 1.0 1.0 Tie2 signaling 2 12 0.4812040133779264 0.9075099812904823 1.0 P62993,Q06124 Metallothioneins bind metals 0 2 0.0 1.0 1.0 Molecules associated with elastic fibres 1 18 0.14134560544378233 0.9980862756412443 1.0 P05556 Egfr interacts with phospholipase c gamma 1 2 2.4082246740220663 0.5008051893494083 1.0 P19174 Dopamine neurotransmitter release cycle 1 18 0.14134560544378233 0.9980862756412443 1.0 O14936 Prc2 methylates histones and dna 4 23 0.5062354681885437 0.9388080659008847 1.0 P16104,P26358,P62805,Q15022 Activated notch1 transmits signal to the nucleus 2 21 0.25294842457313854 0.9934365625959856 1.0 Q92542,Q96J02 Rho gtpases activate rhotekin and rhophilins 1 8 0.3437455222811291 0.9379623427931464 1.0 P61586 Notch1 intracellular domain regulates transcription 5 39 0.35300025601134327 0.9958082107547567 1.0 P63208,Q13547,Q13573,Q13616,Q92769 Cyp2e1 reactions 0 1 0.0 1.0 1.0 Tnfs bind their physiological receptors 0 1 0.0 1.0 1.0 Raf activation 9 33 0.9026148172980222 0.6667162820541698 1.0 P30153,P30154,P31946,P35232,P62140,Q02750,Q13555,Q14738,Q9UQ13 Response to metal ions 0 5 0.0 1.0 1.0 Constitutive signaling by akt1 e17k in cancer 6 25 0.7598618112595622 0.786880197836483 1.0 O15111,P31751,P42345,P49840,P49841,Q96B36 Negative regulation of mapk pathway 10 36 0.925811277923954 0.6433955278603966 1.0 P27361,P28482,P30086,P30153,P30154,P31946,P53041,Q02750,Q14738,Q99956 Tnf receptor superfamily tnfsf members mediating non canonical nf kb pathway 0 5 0.0 1.0 1.0 Protein repair 1 5 0.6018054162487463 0.8239879431862632 1.0 P22061 Eicosanoids 0 1 0.0 1.0 1.0 Lgi adam interactions 1 5 0.6018054162487463 0.8239879431862632 1.0 Q15334 Endogenous sterols 2 12 0.4812040133779264 0.9075099812904823 1.0 P22570,Q16850 Surfactant metabolism 1 8 0.3437455222811291 0.9379623427931464 1.0 Q07065 Map3k8 tpl2 dependent mapk1 3 activation 4 14 0.9630522088353414 0.624675255970463 1.0 O15111,P63208,Q02750,Q13616 Miscellaneous substrates 0 2 0.0 1.0 1.0 Cytochrome p450 arranged by substrate type 3 15 0.6015389762462362 0.8618328607283439 1.0 P16435,P22570,Q16850 Regulation of tlr by endogenous ligand 1 3 1.2039451688398528 0.6473218534129999 1.0 P09429 Xenobiotics 0 4 0.0 1.0 1.0 Activation of kainate receptors upon glutamate binding 2 16 0.3435260391782131 0.9705996719890695 1.0 Q15334,Q9UBI6