term	overlap	setsize	score	pval
Metabolism of rna	380	568	8.34274352089459	7.258648547158942e-17
Regulation of expression of slits and robos	110	136	6.7307594949128005	1.6877974873761193e-11
Eukaryotic translation initiation	93	106	6.570030710182439	5.030488574549042e-11
Influenza infection	107	137	6.514815517537175	7.277904906005434e-11
Rrna processing	133	187	6.427195364850753	1.2997972835867952e-10
Eukaryotic translation elongation	69	81	6.344806471643134	2.2270522544900943e-10
Translation	183	261	6.331458795283256	2.428540293394917e-10
Srp dependent cotranslational protein targeting to membrane	78	98	6.274866056746988	3.4993541019842166e-10
Selenoamino acid metabolism	71	97	6.21557073042207	5.113843141919415e-10
Metabolism of amino acids and derivatives	160	229	6.206924609618644	5.403150190666102e-10
Response of eif2ak4 gcn2 to amino acid deficiency	68	83	6.013604006718923	1.814434249882329e-09
Nonsense mediated decay nmd	73	96	5.998863277754008	1.987035682013449e-09
Signaling by robo receptors	111	162	5.9281240783754345	3.06414937374348e-09
Processing of capped intron containing pre mrna	161	220	5.63038240572381	1.7981050240399505e-08
Auf1 hnrnp d0 binds and destabilizes mrna	36	43	5.6097628145568645	2.0260409874723148e-08
Host interactions of hiv factors	80	106	5.6070344603902775	2.05822692893408e-08
Degradation of axin	32	38	5.500340739271608	3.7905800058635344e-08
Cross presentation of soluble exogenous antigens endosomes	32	39	5.495952844509319	3.886063493350509e-08
Scf skp2 mediated degradation of p27 p21	35	43	5.475371117316507	4.3659563133354344e-08
Stabilization of p53	33	42	5.466013482301559	4.602693451841812e-08
G1 s dna damage checkpoints	33	45	5.283664267471123	1.2662521713254742e-07
Negative regulation of notch4 signaling	35	43	5.28292675222222	1.2713623311042046e-07
Mrna splicing	125	170	5.253006940748148	1.4963589517200594e-07
Metabolism of polyamines	33	42	5.240677961581973	1.599877104046918e-07
Asymmetric localization of pcp proteins	33	41	5.23869143315147	1.617191692204568e-07
Degradation of dvl	33	41	5.222135177141432	1.7687177598356045e-07
Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s	45	54	5.2218221350366685	1.7717109994554934e-07
Regulation of runx3 expression and activity	32	41	5.207564346847383	1.913354967873651e-07
Cellular response to starvation	74	106	5.206155957308376	1.927926314134197e-07
Cytosolic trna aminoacylation	21	23	5.131615541441036	2.872657983299728e-07
Rrna modification in the nucleus and cytosol	47	60	5.129573832309437	2.903988576630216e-07
Regulation of mrna stability by proteins that bind au rich elements	44	71	4.992104555153194	5.972490708661127e-07
Defective cftr causes cystic fibrosis	34	46	4.987418248806876	6.119149897898524e-07
Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1	38	55	4.936082831301075	7.970726541017825e-07
Hedgehog ligand biogenesis	34	46	4.871954312122943	1.1049972539201036e-06
Tnfr2 non canonical nf kb pathway	35	47	4.860382316363649	1.1715927357158762e-06
Dectin 1 mediated noncanonical nf kb signaling	35	47	4.826695043501563	1.388174374339357e-06
The role of gtse1 in g2 m progression after g2 checkpoint	41	55	4.825382846670698	1.3973458441451925e-06
Regulation of hmox1 expression and activity	40	52	4.782641682448687	1.7300636181438731e-06
Regulation of ras by gaps	33	44	4.759060963607555	1.944956895982841e-06
Disorders of transmembrane transporters	63	91	4.739253427898774	2.1450708462822377e-06
Apc c mediated degradation of cell cycle proteins	43	65	4.72460066993092	2.3056797655574e-06
Orc1 removal from chromatin	40	59	4.6879881136597055	2.7590403932631347e-06
Pcp ce pathway	38	56	4.645107932593078	3.398987049818558e-06
Regulation of runx2 expression and activity	34	48	4.618878946845184	3.858188490024617e-06
Glucose metabolism	53	68	4.557255906164385	5.1826265319299125e-06
Degradation of gli1 by the proteasome	34	47	4.5056216932962005	6.617889885207617e-06
Trna aminoacylation	27	41	4.476076905415015	7.602710836440707e-06
Cellular responses to stimuli	232	447	4.457500909542242	8.292068545578957e-06
Fceri mediated nf kb activation	34	55	4.429937584814176	9.426036529314176e-06
Antigen processing cross presentation	41	63	4.423799145670462	9.698018869963576e-06
Cdt1 association with the cdc6 orc origin complex	32	47	4.414380975703066	1.0129943022407772e-05
Signaling by notch4	36	51	4.411132236893562	1.0283149074030716e-05
Cellular response to hypoxia	34	48	4.384147638094604	1.1644078735884024e-05
Abc family proteins mediated transport	39	63	4.373192750828742	1.2244252620252638e-05
The retinoid cycle in cones daylight vision	1	1	-4.35665445295537	1.3206551106037525e-05
Regulation of pten stability and activity	36	50	4.342591280797941	1.4081194976256484e-05
Recycling of bile acids and salts	1	1	-4.339698161588158	1.4267855561467258e-05
Infectious disease	217	480	4.335169253630654	1.4564801378069704e-05
Cyclin a cdk2 associated events at s phase entry	35	53	4.304775768791202	1.6715495512631406e-05
Interactions of rev with host cellular proteins	28	37	4.300357808316916	1.7052255718130738e-05
Histidine catabolism	1	1	-4.29374584460607	1.7568357764563558e-05
Glycolysis	43	56	4.292397871330312	1.7675385683313394e-05
Switching of origins to a post replicative state	43	70	4.286897599217434	1.8118576254000374e-05
Tnfr1 mediated ceramide production	0	1	4.2856681420597456	1.821907875498852e-05
Degradation of beta catenin by the destruction complex	37	58	4.241618560869664	2.2191360999901377e-05
Nuclear envelope breakdown	35	47	4.219451063989823	2.4489787087356163e-05
Adenylate cyclase activating pathway	1	1	-4.20022119684327	2.666543409990396e-05
Gene and protein expression by jak stat signaling after interleukin 12 stimulation	20	26	4.188151773921201	2.8123542110014554e-05
Interactions of vpr with host cellular proteins	30	37	4.173412141198905	3.000714085787948e-05
Runx1 regulates transcription of genes involved in differentiation of hscs	33	49	4.167997876848897	3.0728679627278765e-05
Flt3 signaling through src family kinases	1	1	-4.156969647326634	3.2249681781948425e-05
Nervous system development	144	290	4.15015649211882	3.322480406753314e-05
Diseases associated with surfactant metabolism	1	1	-4.146556013865944	3.375136383532151e-05
Synthesis of dna	54	101	4.140754979341216	3.461645743496611e-05
Transport of fatty acids	0	1	4.08578576117633	4.392789799823049e-05
Uch proteinases	38	58	4.076950637235705	4.563017504954914e-05
Abc transporter disorders	34	52	4.054566491321949	5.022736258553096e-05
Cgmp effects	1	1	-4.043458937188616	5.266838387507633e-05
Nitric oxide stimulates guanylate cyclase	1	1	-4.043458937188616	5.266838387507633e-05
Dna replication pre initiation	43	76	4.040518109400926	5.333324635570236e-05
Hdl remodeling	1	1	-4.016161548939355	5.915371413989234e-05
Mitotic prophase	54	72	4.013858638423233	5.973412909354714e-05
Nuclear import of rev protein	25	34	4.006942938646804	6.150971578455788e-05
Synthesis of bile acids and bile salts via 27 hydroxycholesterol	1	1	-4.005570745409294	6.186791303264272e-05
Downstream signaling events of b cell receptor bcr	34	57	4.004957720977576	6.202857429116193e-05
Rhobtb gtpase cycle	24	31	3.962613837065861	7.413363928909789e-05
Phosphate bond hydrolysis by ntpdase proteins	1	1	-3.961296624187705	7.454385932614827e-05
Programmed cell death	64	136	3.958803281754294	7.532624620365524e-05
Sodium calcium exchangers	0	1	3.9345043887376	8.336854554436002e-05
Ns1 mediated effects on host pathways	29	38	3.927977029122145	8.566339064275397e-05
Hedgehog on state	34	52	3.908461538750978	9.28857307800346e-05
Transport of mature transcript to cytoplasm	56	76	3.881984295725577	0.0001036075697733
Tcr signaling	36	63	3.873249568937585	0.0001073937538573
Activated ntrk2 signals through pi3k	0	1	3.873047492188788	0.0001074828727856
Transcriptional regulation by runx3	35	54	3.8634839286902896	0.0001117812507942
Apoptosis	58	120	3.862886395606865	0.0001120551263937
Mapk6 mapk4 signaling	39	60	3.8573427111134273	0.0001146263937041
Antiviral mechanism by ifn stimulated genes	44	59	3.8545559263060265	0.0001159398793111
Nuclear pore complex npc disassembly	26	34	3.851574904645599	0.0001173606203388
Irs activation	1	1	-3.818009132909217	0.0001345329464621
Interleukin 1 signaling	35	61	3.8034392036668097	0.0001427010270156
Fibronectin matrix formation	0	1	3.784080670564552	0.0001542777809282
Export of viral ribonucleoproteins from nucleus	23	32	3.78018069902773	0.0001567145800782
Androgen biosynthesis	0	1	3.7578407186081058	0.0001713859146956
Dna replication	62	111	3.742785895620183	0.0001819912876499
Interleukin 12 family signaling	26	33	3.695679110773992	0.0002192998129126
Sumoylation of dna replication proteins	26	41	3.673347500138991	0.0002393935717368
Slc transporter disorders	26	39	3.667934109666669	0.0002445181734058
Negative regulation of activity of tfap2 ap 2 family transcription factors	1	1	-3.6639091323877766	0.0002483949379405
Irak4 deficiency tlr2 4	0	1	3.648382710654559	0.0002638963302747
Initiation of nuclear envelope ne reformation	14	19	3.648118089032717	0.0002641682207813
Rhobtb2 gtpase cycle	17	21	3.64107790098189	0.0002714989639782
Biosynthesis of epa derived spms	0	1	3.618030054418399	0.0002968539310792
Cellular response to chemical stress	55	100	3.611948825359654	0.0003039045472987
Dopamine clearance from the synaptic cleft	0	1	3.603274021679474	0.0003142339473392
Hiv infection	93	180	3.5729189521231874	0.0003530240488203
Transcriptional regulation by runx2	36	67	3.563067853311186	0.0003665458853701
Acyl chain remodeling of dag and tag	1	1	-3.562962054763152	0.000366693700585
S phase	59	123	3.5620177009592333	0.0003680155646423
Ampk inhibits chrebp transcriptional activation activity	1	2	-3.556742453580671	0.000375481940817
Termination of o glycan biosynthesis	1	1	-3.5517721479031543	0.0003826460574396
Cytoprotection by hmox1	51	86	3.548668928759088	0.0003871835549609
Regulation of glucokinase by glucokinase regulatory protein	21	30	3.545702939008301	0.000391567350608
Citric acid cycle tca cycle	17	21	3.543227591458277	0.00039526142744
Mitotic g1 phase and g1 s transition	50	100	3.519026507291357	0.0004331334292091
G2 m checkpoints	55	115	3.5092268342846555	0.0004494114409994
Gluconeogenesis	16	22	3.5088370713939243	0.0004500705243168
Folding of actin by cct tric	7	8	3.4980000605550843	0.0004687610261941
Clec7a dectin 1 signaling	34	65	3.479937721410538	0.0005015303523325
Nr1h2 nr1h3 regulate gene expression linked to gluconeogenesis	1	1	-3.4758367545600364	0.0005092621751425
Nr1h2 nr1h3 regulate gene expression linked to triglyceride lipolysis in adipose	1	1	-3.4758367545600364	0.0005092621751425
Nr1h2 nr1h3 regulate gene expression to limit cholesterol uptake	1	1	-3.4758367545600364	0.0005092621751425
Cytokine signaling in immune system	124	243	3.4741282181649678	0.0005125160635943
Ptk6 promotes hif1a stabilization	1	1	-3.4730107245315947	0.0005146547897902
Erbb2 activates ptk6 signaling	1	1	-3.4730107245315947	0.0005146547897902
Tfap2 ap 2 family regulates transcription of cell cycle factors	2	2	-3.472776200465592	0.000515104690836
Interleukin 12 signaling	21	30	3.470937116059664	0.0005186454423569
Activation of ras in b cells	1	1	-3.465469855796633	0.0005293058597897
Apoptotic execution phase	23	39	3.446900667453833	0.0005670570331142
Snrnp assembly	35	48	3.435888700664739	0.0005906135521236
Transport of mature mrnas derived from intronless transcripts	33	43	3.4356135019102454	0.0005912137531995
Defensins	1	1	-3.43523647760679	0.0005920369548677
Alpha defensins	1	1	-3.43523647760679	0.0005920369548677
Purine ribonucleoside monophosphate biosynthesis	8	10	3.402138632257333	0.0006686071235895
Regulation of signaling by nodal	1	1	-3.374431275192746	0.0007396838285651
Reelin signalling pathway	2	2	-3.3609527889692767	0.0007767410111036
Oxidative stress induced senescence	23	41	-3.3602489505583137	0.0007787226783952
Signaling by the b cell receptor bcr	34	65	3.354397363219167	0.0007953805380349
Butyrophilin btn family interactions	1	1	-3.3390701420953213	0.0008405933624335
Viral messenger rna synthesis	30	41	3.329977885501562	0.0008685288185263
Beta catenin independent wnt signaling	38	73	3.328850175765125	0.0008720530217016
Sumoylation of sumoylation proteins	21	32	3.321766433292796	0.0008944953685987
Transport of the slbp dependant mature mrna	28	36	3.32057494849716	0.0008983223540215
G alpha 12 13 signalling events	11	24	-3.3051754437511867	0.000949169642892
Ub specific processing proteases	53	102	3.2860812325968234	0.0010159170771508
Mitotic metaphase and anaphase	91	188	3.2806406467601086	0.0010357161122547
Pyruvate metabolism and citric acid tca cycle	28	41	3.275866887314512	0.0010533819629898
Signaling by membrane tethered fusions of pdgfra or pdgfrb	1	1	-3.2717476915005523	0.0010688491631976
Chylomicron remodeling	2	2	-3.267438153347437	0.001085255755556
Rhobtb1 gtpase cycle	16	21	3.261612215096206	0.001107805760927
Postmitotic nuclear pore complex npc reformation	19	25	3.258638289995727	0.0011194830027743
Sodium proton exchangers	1	1	-3.249505378929946	0.0011560589187284
Intrinsic pathway of fibrin clot formation	1	2	3.237520930672827	0.0012057309457262
Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation	2	3	3.2314869548121403	0.0012314794501002
Cs ds degradation	1	2	3.221168365159216	0.0012766912301271
Tcf dependent signaling in response to wnt	41	83	3.220464854886214	0.0012798288405617
Sumoylation of rna binding proteins	24	41	3.2020432047851424	0.0013645653014564
Signaling by interleukins	70	154	3.178726734453214	0.0014792347573422
Neutrophil degranulation	115	242	3.1579780724109257	0.0015886750727502
Metabolism of carbohydrates	72	135	3.133872177404524	0.0017251598783365
Neurotransmitter clearance	1	2	3.133708041036556	0.0017261250841011
Regulation of hsf1 mediated heat shock response	41	67	3.1243029996982266	0.0017822682189878
Erythropoietin activates stat5	1	2	-3.074772721194165	0.0021066302147043
Abacavir metabolism	0	1	3.0697733128230893	0.0021422129853059
Blood group systems biosynthesis	2	2	-3.0682710282044985	0.0021530125216804
Rmts methylate histone arginines	17	23	3.064254813358436	0.0021821296121151
Abacavir transmembrane transport	0	1	3.0530380317571986	0.0022653722567409
Interleukin 1 family signaling	34	69	3.0380327461106096	0.0023812807666858
Aspartate and asparagine metabolism	4	5	3.030296391113725	0.002443138536968
Chemokine receptors bind chemokines	2	2	-3.030154435315646	0.0024442871915799
Activated ntrk3 signals through pi3k	1	1	-3.0186958495164826	0.0025386525534485
Signaling by notch1	13	26	-3.0181699028344986	0.0025430628417835
Notch1 intracellular domain regulates transcription	10	19	-3.012526882937691	0.0025908248761132
Ncam1 interactions	1	1	-3.011719426600543	0.0025977257972371
Il 6 type cytokine receptor ligand interactions	2	2	-3.010583519447056	0.0026074622742493
Fertilization	1	1	-3.009725067552216	0.0026148426540761
Defective b4galt1 causes b4galt1 cdg cdg 2d	1	1	-3.009725067552216	0.0026148426540761
Interaction with cumulus cells and the zona pellucida	1	1	-3.009725067552216	0.0026148426540761
Vldl clearance	3	3	-2.9889970283001355	0.0027989485395409
Transcriptional regulation of white adipocyte differentiation	15	33	-2.964527632001228	0.0030314801680189
Golgi to er retrograde transport	65	93	2.9471593050987948	0.0032070793669847
Signaling by notch1 pest domain mutants in cancer	11	21	-2.935999566947152	0.0033247478661924
Terminal pathway of complement	1	1	-2.918463065766788	0.0035176154398288
Inositol phosphate metabolism	9	18	-2.917495483486102	0.0035285475886666
Signaling by gpcr	36	94	-2.9099755286453632	0.0036145705632739
Association of tric cct with target proteins during biosynthesis	12	22	2.909839844053622	0.0036161400682934
Beta oxidation of octanoyl coa to hexanoyl coa	4	5	2.9002892600973817	0.003728184384562
Dna strand elongation	21	34	2.900159343232388	0.0037297300474907
Signaling by alk in cancer	29	41	2.8875189854230614	0.003882931717942
Digestion	0	1	2.885865103543042	0.0039033942285593
Digestion and absorption	0	1	2.885865103543042	0.0039033942285593
Creatine metabolism	1	3	2.8760197008052124	0.0040272457531178
Sumoylation of ubiquitinylation proteins	21	35	2.866079917346972	0.0041558931719392
Metabolism of nucleotides	36	62	2.859716182623358	0.0042402030362374
Nuclear envelope ne reassembly	44	62	2.851578652071101	0.0043502722454946
Trna processing in the nucleus	34	53	2.846055688282244	0.0044264453141196
Norepinephrine neurotransmitter release cycle	2	3	-2.8368711068824912	0.0045557999584697
Serotonin neurotransmitter release cycle	2	3	-2.8368711068824912	0.0045557999584697
Acetylcholine neurotransmitter release cycle	2	3	-2.8368711068824912	0.0045557999584697
Passive transport by aquaporins	0	1	2.836487204095518	0.0045612806086319
Defects of contact activation system cas and kallikrein kinin system kks	0	1	2.8344657826352258	0.004590237337563
Gamma carboxylation transport and amino terminal cleavage of proteins	0	1	2.8344657826352258	0.004590237337563
Defective factor ix causes hemophilia b	0	1	2.8344657826352258	0.004590237337563
M phase	141	277	2.8183727099060274	0.0048267745106822
Acyl chain remodeling of cl	1	3	2.8129410263053387	0.0049090653493033
Metabolism of angiotensinogen to angiotensins	2	3	-2.8062925224315363	0.0050115174379989
Cellular response to heat stress	47	79	2.8039323674914693	0.0050483493585526
Activation of the phototransduction cascade	1	1	-2.7975666055570025	0.0051489149907486
Sensory perception of taste	1	1	-2.7975666055570025	0.0051489149907486
Activation of the tfap2 ap 2 family of transcription factors	2	3	-2.789880430811208	0.0052727510212997
Pou5f1 oct4 sox2 nanog activate genes related to proliferation	0	1	2.78174308434231	0.0054067822932033
Release of hh np from the secreting cell	1	1	-2.7729674761055185	0.0055547672128808
Signaling by notch1 t 7 9 notch1 m1580 k2555 translocation mutant	1	1	-2.7729674761055185	0.0055547672128808
Runx3 regulates yap1 mediated transcription	3	3	-2.7727629795212585	0.0055582588445211
Yap1 and wwtr1 taz stimulated gene expression	3	3	-2.7727629795212585	0.0055582588445211
Developmental biology	161	388	2.772245513511669	0.0055671030514865
Mitochondrial calcium ion transport	13	19	2.767786172801406	0.0056438471508304
Hydrolysis of lpc	0	1	2.767493843957189	0.0056489112304658
Transcriptional regulation by small rnas	24	47	2.7669400642701203	0.005658515721717
Regulation of lipid metabolism by pparalpha	18	48	-2.764359301678221	0.0057034698060418
Pre notch expression and processing	12	27	-2.7460847663685035	0.0060311178478968
Mrna decay by 3 to 5 exoribonuclease	12	16	2.74602466687601	0.0060322227997831
Interleukin 2 signaling	3	3	-2.740041597336768	0.0061431408910854
Defective ext2 causes exostoses 2	1	1	-2.739023663770474	0.0061621937915856
Runx1 regulates transcription of genes involved in differentiation of keratinocytes	1	2	-2.7359137038340737	0.0062207337159829
Josephin domain dubs	1	3	2.728819377804211	0.0063561507750415
Ticam1 dependent activation of irf3 irf7	1	1	-2.725613553529977	0.0064182094990967
Condensation of prometaphase chromosomes	8	11	2.7219396521286616	0.0064899992840321
Beta oxidation of lauroyl coa to decanoyl coa coa	3	4	2.7087132519292525	0.0067544688958331
O glycosylation of tsr domain containing proteins	2	2	-2.706617630587745	0.0067972496831125
Foxo mediated transcription of cell death genes	4	4	-2.7040535434518698	0.0068499250466376
Cellular hexose transport	2	3	-2.6987000172409794	0.0069610892747584
Nucleotide biosynthesis	10	15	2.698228587054765	0.0069709555749994
Zinc influx into cells by the slc39 gene family	2	3	-2.694304372021294	0.0070535719433353
Estrogen biosynthesis	0	1	2.6876787857436963	0.0071950573199655
Apoptotic cleavage of cellular proteins	11	27	2.686353908832828	0.0072236529958522
Common pathway of fibrin clot formation	1	1	-2.6842152366410805	0.007270028605042
Protein repair	0	1	2.683566166027465	0.0072841559972478
Separation of sister chromatids	67	146	2.6762708223995197	0.0074446461124142
Retinoid cycle disease events	2	2	-2.664914740342992	0.0077007843881209
Hedgehog off state	37	71	2.6647352622522167	0.0077048951798932
Loss of function of smad2 3 in cancer	2	2	-2.6556188106889063	0.007916304187399
Runx3 regulates bcl2l11 bim transcription	2	2	-2.6556188106889063	0.007916304187399
Foxo mediated transcription of cell cycle genes	2	2	-2.6556188106889063	0.007916304187399
Regulation of foxo transcriptional activity by acetylation	4	5	-2.6369967728257686	0.0083643627335203
Unfolded protein response upr	31	53	2.6286897718406563	0.0085714515538559
Cholesterol biosynthesis	9	23	2.628681236241274	0.0085716666781057
Hdl clearance	1	2	2.6245705616597568	0.0086758313905734
Interconversion of nucleotide di and triphosphates	13	23	2.6216744764986726	0.008749896161043
Ca2 pathway	9	18	-2.6210493862908235	0.0087659562223703
Cross presentation of particulate exogenous antigens phagosomes	1	1	-2.6175469765055834	0.008856429694489
Abacavir transport and metabolism	1	2	2.616261326645718	0.0088898490412916
Vitamin c ascorbate metabolism	1	3	2.615471039382035	0.0089104477287873
Dectin 2 family	2	3	-2.6042473333106195	0.0092076283473889
Protein methylation	5	7	2.5997082860746272	0.009330303735894
Resolution of abasic sites ap sites	24	32	2.598507903055639	0.0093629889731734
Acyl chain remodelling of pi	0	1	2.586368970351089	0.0096993040306692
The citric acid tca cycle and respiratory electron transport	72	133	2.5843324248414605	0.0097567704513279
Negative regulation of tcf dependent signaling by dvl interacting proteins	1	1	-2.5808619330382263	0.00985539882556
Cell death signalling via nrage nrif and nade	10	25	-2.5782596111610587	0.0099299363520231
Nrage signals death through jnk	9	19	-2.569474780490872	0.010185280513669
Apoptosis induced dna fragmentation	8	11	2.563766108962187	0.0103543293422083
Rna polymerase ii transcription termination	38	58	2.559690257321808	0.0104765492384861
Beta oxidation of decanoyl coa to octanoyl coa coa	4	6	2.5574337747542453	0.0105447634226976
Elevation of cytosolic ca2 levels	2	2	-2.5517298345639783	0.0107189600174768
Synthesis of 5 eicosatetraenoic acids	0	1	2.546776229577532	0.0108723125843634
Polymerase switching	10	15	2.5437434660065064	0.0109671597158151
Mrna editing c to u conversion	1	1	-2.5419059521919616	0.0110249834556368
Ras signaling downstream of nf1 loss of function variants	1	2	-2.5418632235012386	0.0110263312785412
Translesion synthesis by polh	11	13	2.535698781522656	0.0112223216782629
Deadenylation dependent mrna decay	27	52	2.527302478277297	0.0114942459494453
Defective lfng causes scdo3	1	1	-2.522889265693391	0.0116395046957014
Synthesis of lipoxins lx	0	1	2.5195867988587186	0.0117492668145007
Mrna splicing minor pathway	28	42	2.5143624241215914	0.0119247818162779
Sumoylation	45	112	2.513748809720706	0.0119455482439319
Phase 2 plateau phase	1	1	-2.5080689659008764	0.0121392971595111
Phase 3 rapid repolarisation	1	1	-2.5080689659008764	0.0121392971595111
Pou5f1 oct4 sox2 nanog repress genes related to differentiation	2	2	-2.504508024657632	0.0122621823624449
Cristae formation	16	25	2.491784353683097	0.0127103181128327
Beta oxidation of hexanoyl coa to butanoyl coa	3	5	2.4900367708257893	0.0127729879635902
Post translational protein modification	221	642	2.482061098393937	0.0130624875784992
Mitochondrial protein import	24	48	2.476076432206553	0.0132835137674682
Pten regulation	44	95	2.463052411487753	0.0137759776610906
Gene silencing by rna	41	60	2.458186259958842	0.0139640729217269
Diseases of signal transduction by growth factor receptors and second messengers	102	211	2.45745811908648	0.0139924124711887
C type lectin receptors clrs	36	77	2.4517575184055618	0.0142160423839776
Pyrimidine catabolism	1	2	-2.4451670679744173	0.0144785055788645
Lagging strand synthesis	15	22	2.443276704418005	0.0145545732627163
Signaling by wnt	65	125	2.436552601936026	0.0148280126440538
Apoptotic cleavage of cell adhesion proteins	3	7	2.429794201166112	0.0151073983202101
Lysine catabolism	5	7	2.421871011377528	0.015440830225379
Interferon signaling	58	84	2.412437490832508	0.0158462544176345
Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux	8	13	-2.409788993493314	0.0159617490709522
Irf3 mediated induction of type i ifn	4	6	2.4095494287828654	0.0159722323275577
Nr1h2 nr1h3 regulate gene expression to control bile acid homeostasis	1	2	-2.403892625195549	0.0162215371316167
Ptk6 regulates proteins involved in rna processing	1	3	2.394239226665082	0.0166548819529803
Cell cycle checkpoints	74	207	2.391700263942873	0.0167705319907631
Resolution of ap sites via the multiple nucleotide patch replacement pathway	21	26	2.391507073951303	0.0167793606107631
Synthesis of wybutosine at g37 of trna phe	2	2	-2.391048444055207	0.0168003359533761
Cell cycle mitotic	180	374	2.3875690043427653	0.0169602185045489
Trail signaling	2	2	-2.3795229890441907	0.0173350616911549
Tnf receptor superfamily tnfsf members mediating non canonical nf kb pathway	1	1	-2.3778217001862725	0.0174152445323749
Golgi cisternae pericentriolar stack reorganization	10	12	2.3770367353295945	0.017452349945759
Chondroitin sulfate biosynthesis	3	3	-2.3721700593201254	0.0176839493137006
Lgi adam interactions	0	1	2.371793707334185	0.0177019711560402
Scavenging of heme from plasma	1	1	-2.368134960193136	0.017878013015987
Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand	31	38	2.363547779600198	0.01810089242282
Copi dependent golgi to er retrograde traffic	42	65	2.3556479595740583	0.0184904317109309
Olfactory signaling pathway	2	2	-2.355461962645954	0.0184996909254926
Sumo is transferred from e1 to e2 ube2i ubc9	1	3	2.354860773320941	0.0185296468189815
Sumo is conjugated to e1 uba2 sae1	1	3	2.354860773320941	0.0185296468189815
Phospholipase c mediated cascade fgfr2	0	1	2.351556444432455	0.0186950529757574
Phospholipase c mediated cascade fgfr4	0	1	2.351556444432455	0.0186950529757574
Deubiquitination	62	141	2.3407659410164614	0.0192442273662305
Translesion synthesis by y family dna polymerases bypasses lesions on dna template	15	26	2.3375429545724984	0.0194109701641909
Signaling by notch1 hd domain mutants in cancer	2	2	-2.3323001924938733	0.0196849044161777
Zinc transporters	3	6	-2.326036432035739	0.0200166072083689
Metal ion slc transporters	3	6	-2.326036432035739	0.0200166072083689
Base excision repair	27	37	2.3212995775412875	0.0202706810266146
Sumoylation of chromatin organization proteins	25	49	2.3202088364141087	0.0203295828176068
Activation of the ap 1 family of transcription factors	3	6	-2.3184403370280844	0.020425401972361
Defects in biotin btn metabolism	5	7	2.3177092359224094	0.0204651287376256
Innate immune system	168	440	2.314921054979349	0.0206172528635111
Death receptor signalling	25	56	-2.306425604762367	0.0210868626498426
Cell cycle	246	454	2.2985278070746498	0.0215317671095018
Mitotic telophase cytokinesis	10	13	2.2920363166809943	0.0219035476360851
Wnt5a dependent internalization of fzd2 fzd5 and ror2	6	8	2.291234658939316	0.021949845411719
Nef mediated cd4 down regulation	5	6	2.2835483995800074	0.0223980853098928
Nef mediated cd8 down regulation	5	6	2.2835483995800074	0.0223980853098928
Electric transmission across gap junctions	2	2	-2.2819038553317843	0.0224950171844344
Interleukin 17 signaling	18	36	-2.2636469242371757	0.023595839328709
Fc epsilon receptor fceri signaling	34	78	2.262668343394611	0.0236561416727743
Pd 1 signaling	1	2	2.2623268190327126	0.0236772186228366
Pi 3k cascade fgfr3	1	2	2.262326819032702	0.0236772186228373
Pi 3k cascade fgfr2	1	2	2.262326819032702	0.0236772186228373
Pi 3k cascade fgfr4	1	2	2.262326819032702	0.0236772186228373
Pi 3k cascade fgfr1	1	2	2.262326819032702	0.0236772186228373
Glycosphingolipid metabolism	13	21	2.2474765635547143	0.0246095867361884
Mitochondrial trna aminoacylation	11	22	2.245255311186597	0.0247517471311979
Runx1 and foxp3 control the development of regulatory t lymphocytes tregs	1	1	-2.2412255157674994	0.0250114708610178
Runx1 regulates transcription of genes involved in wnt signaling	1	1	-2.2412255157674994	0.0250114708610178
Runx1 regulates transcription of genes involved in interleukin signaling	1	1	-2.2412255157674994	0.0250114708610178
Runx2 regulates chondrocyte maturation	1	1	-2.2412255157674994	0.0250114708610178
Runx3 regulates immune response and cell migration	1	1	-2.2412255157674994	0.0250114708610178
Mapk family signaling cascades	56	132	2.2401447085215827	0.0250815298402671
Pcna dependent long patch base excision repair	15	22	2.235903265602454	0.0253581083634157
Synthesis of bile acids and bile salts via 24 hydroxycholesterol	1	1	-2.2335748644993934	0.0255110593153333
Defective chst14 causes eds musculocontractural type	0	1	2.2314019173915454	0.0256545179685305
Rrna modification in the mitochondrion	3	6	-2.217382234843841	0.0265969826470264
Gap filling dna repair synthesis and ligation in gg ner	15	22	2.2165684534813863	0.0266525952946428
Trp channels	1	2	-2.215726066217947	0.0267102685910409
G alpha q signalling events	12	30	-2.214122073848675	0.0268203825454964
Pexophagy	2	5	-2.212416722616527	0.0269378844773731
Negative regulation of flt3	0	2	2.210567001593684	0.0270658359641058
Hcmv late events	24	50	2.2078579593285435	0.0272541762552269
Cd209 dc sign signaling	7	14	-2.205119151456503	0.0274457345177774
P75 ntr receptor mediated signalling	13	37	-2.202107925583377	0.0276576857755861
Class i mhc mediated antigen processing presentation	77	176	2.198480809205701	0.0279148606571979
Erythropoietin activates phosphoinositide 3 kinase pi3k	1	1	-2.194125854608868	0.0282263630344545
Cd22 mediated bcr regulation	1	1	-2.194125854608868	0.0282263630344545
Hats acetylate histones	26	53	-2.192811879157677	0.0283209357110014
Beta oxidation of butanoyl coa to acetyl coa	2	4	2.188929668937682	0.0286019522637284
Rho gtpases activate rhotekin and rhophilins	2	3	-2.187870665479278	0.0286790246290451
Hdr through mmej alt nhej	6	8	2.1827407899490456	0.0290549042368679
Cohesin loading onto chromatin	7	10	2.1763130463981364	0.029531860664691
Signaling by hedgehog	39	87	2.175501179197567	0.0295925798459335
Deposition of new cenpa containing nucleosomes at the centromere	10	23	-2.1749976679502723	0.0296302911431141
Glycosaminoglycan metabolism	17	33	-2.172971407072891	0.0297824693642401
Regulation of gene expression by hypoxia inducible factor	2	3	-2.1719263263774424	0.0298612203786721
Sumoylation of dna damage response and repair proteins	29	64	2.1713927166175773	0.0299014990039381
Toll like receptor cascades	28	61	-2.1698900485816788	0.0300151763898444
Apobec3g mediated resistance to hiv 1 infection	2	3	2.16370238187641	0.0304871980957401
Regulation of beta cell development	5	10	-2.160652890206731	0.0307221625387752
Rhog gtpase cycle	22	49	2.1568110622973267	0.0310203888333293
Inhibition of replication initiation of damaged dna by rb1 e2f1	4	7	2.1514564683290143	0.0314401882483426
Chylomicron clearance	2	3	-2.1467066540360555	0.0318166427034061
Met receptor activation	0	1	2.139247257758458	0.0324156487072651
Na cl dependent neurotransmitter transporters	1	1	-2.130208141265165	0.0331544332285678
Smad2 smad3 smad4 heterotrimer regulates transcription	8	13	-2.115575099669645	0.0343809614712851
Copi mediated anterograde transport	49	73	2.1147047583880747	0.0344551185634134
Plasma lipoprotein assembly	4	8	-2.110315992855678	0.0348311469547488
Fructose catabolism	1	1	-2.1069561818790747	0.0351213779636427
Ubiquinol biosynthesis	5	6	-2.0968546782400885	0.036006441582328
Synthesis of ip2 ip and ins in the cytosol	3	7	-2.0937647185967645	0.0362809445135692
Pp2a mediated dephosphorylation of key metabolic factors	2	3	2.092061307421841	0.0364330318152406
Dap12 signaling	6	10	-2.0915802523242992	0.036476080574253
Dermatan sulfate biosynthesis	2	3	-2.0903175456406515	0.0365892841869868
Heme degradation	2	5	2.0855334835976103	0.0370209020576468
Mastl facilitates mitotic progression	3	6	2.078619215409236	0.0376523634079624
Activation of nima kinases nek9 nek6 nek7	3	5	2.077657875454586	0.0377408815004045
Presynaptic function of kainate receptors	4	6	-2.0723660743650703	0.0382313147061612
N glycan antennae elongation	4	4	-2.066956439112513	0.0387382588060183
Ca dependent events	8	17	-2.0657767803715688	0.0388495615405577
Rap1 signalling	4	8	-2.0575342991214947	0.039634859150107
Protein localization	43	111	2.0533977311716014	0.0400340191753736
Signaling by notch2	4	7	-2.053379811414964	0.0400357557416364
Transcriptional regulation by runx1	47	99	2.0482016536082788	0.0405402444969742
Signaling by mapk mutants	1	2	2.046322530333462	0.0407246484382017
Transport of small molecules	88	234	2.0384411268713176	0.0415058368458391
Reduction of cytosolic ca levels	2	4	2.0382299349251265	0.0415269431168894
Nr1h2 and nr1h3 mediated signaling	8	15	-2.029036467543357	0.0424545760748042
Fgfr2 alternative splicing	9	21	2.0289591291007785	0.0424624533634485
Sting mediated induction of host immune responses	4	7	2.018152522056799	0.0435753790784514
Synthesis of pyrophosphates in the cytosol	3	5	-2.016725543186332	0.0437241627813793
Neurofascin interactions	0	1	2.016593649713573	0.0437379362648735
Telomere maintenance	32	56	2.0162483252447982	0.0437740154578549
G protein mediated events	11	25	-2.016082043225477	0.0437913974178107
Collagen biosynthesis and modifying enzymes	10	12	2.015508379506512	0.0438514089586745
Fatty acids bound to gpr40 ffar1 regulate insulin secretion	2	3	-2.0141186020494137	0.043997082937458
Depolymerisation of the nuclear lamina	7	11	2.0103627407697564	0.0443928109294551
Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein	14	43	-2.009276117583652	0.0445078592133316
Transport of bile salts and organic acids metal ions and amine compounds	5	12	-1.999798580963637	0.0455220178944812
Diseases of base excision repair	1	1	-1.998807765877308	0.0456291572209788
Antigen processing ubiquitination proteasome degradation	55	140	1.9929840653779152	0.0462631919774756
N glycan antennae elongation in the medial trans golgi	6	8	-1.9928750076210784	0.0462751356566759
Transcription coupled nucleotide excision repair tc ner	37	63	1.992501075532455	0.0463161072937587
Activated ntrk2 signals through cdk5	1	2	1.9923963708320451	0.0463275852311202
Iron uptake and transport	13	23	1.9884125622151083	0.0467660805845866
Glucuronidation	2	3	1.9878933861073649	0.0468234823869604
Rab regulation of trafficking	20	71	-1.9856879800568352	0.0470679804914524
Assembly of active lpl and lipc lipase complexes	0	1	1.973569860719132	0.048430673608
Fceri mediated mapk activation	8	18	-1.963627647683946	0.0495732887251085
P75ntr signals via nf kb	5	6	-1.9621273657901792	0.049747657623437
Er to golgi anterograde transport	65	106	1.959018323382424	0.050110640950971
Toll like receptor tlr1 tlr2 cascade	19	41	-1.9555814788697767	0.0505144764545817
Toxicity of botulinum toxin type d botd	1	1	-1.9516048949879936	0.050985131642899
Neurotoxicity of clostridium toxins	1	1	-1.9516048949879936	0.050985131642899
Jnk c jun kinases phosphorylation and activation mediated by activated human tak1	7	10	-1.9505351990422368	0.0511123622623916
Hcmv early events	29	62	1.94844104259856	0.0513622129004531
Gap junction assembly	4	10	-1.947970789885668	0.051418458385064
Interleukin 1 processing	3	3	-1.94720777955756	0.0515098293969462
Extension of telomeres	24	41	1.9452012130135028	0.0517507659172946
Formation of xylulose 5 phosphate	1	3	1.9448355671567776	0.0517947719026015
Mitochondrial fatty acid beta oxidation of saturated fatty acids	4	8	1.9446996103147012	0.0518111424799605
Glucagon signaling in metabolic regulation	6	13	-1.9342056206974645	0.0530878516037736
Vasopressin regulates renal water homeostasis via aquaporins	6	13	-1.9342056206974645	0.0530878516037736
Sumoylation of dna methylation proteins	4	9	-1.933749306823902	0.0531439582988879
Aryl hydrocarbon receptor signalling	2	3	1.9336357967325144	0.053157922778714
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	3	5	1.929620317684626	0.0536538994740303
Calcineurin activates nfat	1	3	-1.9288682756348576	0.0537472171154793
Hsf1 activation	10	18	1.928811043991953	0.0537543242871887
Tp53 regulates transcription of cell death genes	13	17	-1.9280778455582308	0.053845444176074
Signaling by rho gtpases miro gtpases and rhobtb3	188	400	1.9219158660404323	0.0546163450796925
Keratan sulfate biosynthesis	5	6	-1.9214196205736065	0.0546788269171765
Polymerase switching on the c strand of the telomere	10	19	1.9209053886793983	0.0547436362949862
Notch4 intracellular domain regulates transcription	3	6	-1.919140947503194	0.0549664985339397
Termination of translesion dna synthesis	11	23	1.916652637505619	0.0552820760448329
Maturation of sars cov 1 nucleoprotein	2	4	-1.910332155995247	0.0560904600291582
Fcgr3a mediated il10 synthesis	9	17	-1.9071470745376464	0.0565015447999868
Runx3 regulates notch signaling	3	5	-1.9068388741161	0.0565414556352048
Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells	3	5	-1.9068388741161	0.0565414556352048
Neddylation	48	114	1.9039695322239416	0.0569141523297946
Dopamine neurotransmitter release cycle	3	5	-1.9027904744701631	0.0570678906542716
Dag and ip3 signaling	9	19	-1.90213091240888	0.0571540420721474
Receptor type tyrosine protein phosphatases	2	4	-1.9005945810606435	0.0573551358527004
Signaling by wnt in cancer	6	11	1.8982249470580237	0.0576664558534525
Attachment and entry	2	3	-1.8932436710671852	0.0583254722426658
Myd88 independent tlr4 cascade	20	46	-1.890729146450721	0.0586605096156878
Pi metabolism	18	39	-1.8889117827814403	0.0589036503680682
Pi5p regulates tp53 acetylation	5	8	-1.8866494019204525	0.0592074974113661
Regulation of tnfr1 signaling	11	16	-1.8851330344679689	0.0594118790387312
Ptk6 regulates cell cycle	1	2	1.884820613068798	0.0594540610037113
G protein activation	5	7	-1.883306218364764	0.0596588812027856
Alk mutants bind tkis	4	7	1.878650196040852	0.0602922723871177
Signaling by nuclear receptors	30	106	-1.8743393948590188	0.0608836609662932
Energy dependent regulation of mtor by lkb1 ampk	6	16	-1.8685605273821573	0.0616839817724474
Sealing of the nuclear envelope ne by escrt iii	5	20	-1.8667042024120584	0.0619429065716716
Carnitine metabolism	4	6	1.860356391334527	0.0628351201446628
Cellular senescence	28	83	-1.8590408144357269	0.0630213533969443
Keratan sulfate degradation	3	5	1.8579338907423524	0.063178402914191
Insulin receptor recycling	8	11	1.8547938864824705	0.0636256654024536
Regulation of fzd by ubiquitination	1	1	-1.8531239083338031	0.0638646007384435
Toll like receptor 9 tlr9 cascade	20	44	-1.837013959404716	0.0662078346478027
Flt3 signaling by cbl mutants	1	1	-1.8349114327285976	0.0665188134199015
Signaling by notch3	7	14	-1.83463955756886	0.0665591134044374
Runx1 regulates transcription of genes involved in bcr signaling	2	2	-1.8337730371311216	0.0666876917030023
Heme signaling	10	16	-1.8314958442285028	0.067026567425795
Ire1alpha activates chaperones	16	33	1.8288069020541216	0.067428540650984
Ptk6 regulates rtks and their effectors akt1 and dok1	2	3	-1.8247353830730857	0.0680409710371989
Chrebp activates metabolic gene expression	4	5	1.8192432913762104	0.0688743208133535
Sumo is proteolytically processed	2	2	-1.8164348880752144	0.0693036875025354
Killing mechanisms	2	4	-1.811867924301877	0.0700066066377615
Formation of fibrin clot clotting cascade	1	3	1.8110137152397352	0.0701387286409405
Ntrk2 activates rac1	1	2	-1.8109628746401925	0.0701465986922684
Scavenging by class f receptors	3	5	1.8107298335762447	0.0701826823861972
Synthesis of prostaglandins pg and thromboxanes tx	3	4	1.8090158700181345	0.0704485378770489
Cdc6 association with the orc origin complex	5	10	-1.8088718084927975	0.0704709210665885
Resolution of d loop structures through synthesis dependent strand annealing sdsa	12	19	-1.8078374815028933	0.0706317983292286
Resolution of d loop structures	12	19	-1.8078374815028933	0.0706317983292286
Adaptive immune system	106	301	1.8011789280449853	0.0716746825327225
Tnf signaling	13	20	-1.800656300202096	0.0717570694106477
A tetrasaccharide linker sequence is required for gag synthesis	2	3	-1.7986556717530595	0.0720731650492136
Tysnd1 cleaves peroxisomal proteins	3	6	1.7971508519570654	0.0723116745682499
Phosphorylation of the apc c	9	14	1.79117909515684	0.0732645597379955
Flt3 signaling	6	12	-1.7882801789007905	0.073730816080122
Unwinding of dna	6	12	1.7833287263238176	0.0745328078730183
Mhc class ii antigen presentation	48	76	1.7794866392958246	0.0751600134198375
Copi independent golgi to er retrograde traffic	27	36	1.7733945739635657	0.0761633474912888
Vldl assembly	2	3	-1.7682231462187443	0.0770236061471889
Met interacts with tns proteins	1	2	1.7673979291675757	0.0771616095169094
Met activates pi3k akt signaling	1	2	1.7673979291675666	0.0771616095169109
Zinc efflux and compartmentalization by the slc30 family	3	3	-1.7639858596002886	0.0777343599279998
Recycling pathway of l1	17	28	1.7628917811381637	0.077918743499739
Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	9	13	1.7588138954581929	0.0786091238383699
Sphingolipid metabolism	22	39	1.758336706617828	0.0786902355553822
Pka mediated phosphorylation of creb	5	9	-1.757622641726261	0.0788117382289395
Opioid signalling	12	36	-1.753845824897647	0.0794569285606188
Gdp fucose biosynthesis	2	4	-1.7519610815359368	0.0797805002319014
Rho gtpases activate ktn1	7	9	1.7453144446891726	0.0809301489247391
Mitotic g2 g2 m phases	49	135	1.7445406982439269	0.0810648511782772
Class b 2 secretin family receptors	4	8	-1.7431478136273415	0.0813077984806931
Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex	7	13	1.741658768234032	0.0815681713559723
Tyrosine catabolism	1	2	1.7414042068537992	0.081612751327015
Uptake and function of diphtheria toxin	3	4	1.74010431702608	0.0818407023699689
P75ntr regulates axonogenesis	1	3	1.7396205052005702	0.0819256762659461
Chondroitin sulfate dermatan sulfate metabolism	7	11	-1.7332315861814624	0.0830545150223052
Dual incision in gg ner	18	31	1.7327107553041894	0.0831470919091121
Diseases associated with n glycosylation of proteins	11	17	-1.7323024176984294	0.0832197317411813
Notch2 intracellular domain regulates transcription	2	4	-1.7317110404806717	0.0833250239162781
Wnt ligand biogenesis and trafficking	4	6	1.7311126489060005	0.0834316747791945
Transport of nucleotide sugars	1	2	-1.728995397713351	0.0838099187742495
Clec7a inflammasome pathway	4	4	-1.7267612446594856	0.0842105513760331
Sumoylation of immune response proteins	4	4	-1.7267612446594856	0.0842105513760331
Advanced glycosylation endproduct receptor signaling	7	9	1.7246256063608114	0.084594965713133
Signaling by tgfb family members	17	42	-1.722886417412397	0.0849090670502421
Ethanol oxidation	2	4	1.721726248292392	0.0851191201326451
Cooperation of prefoldin and tric cct in actin and tubulin folding	11	22	1.712337326967731	0.0868345215826782
Nuclear events stimulated by alk signaling in cancer	10	13	1.7074383006187204	0.0877406165883307
P75ntr recruits signalling complexes	2	4	-1.705240969350991	0.0881494919620333
Telomere c strand lagging strand synthesis	16	28	1.7051079649701557	0.0881742904016702
Met activates rap1 and rac1	4	6	1.7007161901324193	0.0889962934616963
Binding of tcf lef ctnnb1 to target gene promoters	1	2	-1.69981627512324	0.0891654892245925
Runx3 regulates wnt signaling	1	2	-1.69981627512324	0.0891654892245925
Aquaporin mediated transport	6	14	-1.6940699791733054	0.0902519861703285
G alpha i signalling events	17	47	-1.6913322746158868	0.0907733591997157
Dap12 interactions	6	12	-1.6902841156801929	0.0909736124998001
Er quality control compartment erqc	7	10	-1.6870938305800816	0.091585311158489
Signaling by notch	41	94	1.6856112846055824	0.091870694257252
Glucagon like peptide 1 glp1 regulates insulin secretion	7	15	-1.6808746580232763	0.0927872632846382
Regulation of gene expression in early pancreatic precursor cells	1	1	-1.677746099310563	0.0933966758088187
Regulation of tp53 activity through acetylation	15	29	-1.6747891307743696	0.0939756122090929
Cdc42 gtpase cycle	23	66	-1.674021989339511	0.0941262778203564
Assembly of the hiv virion	5	7	-1.6735618057342896	0.0942167501954709
Organic anion transporters	1	2	1.6732385130883576	0.0942803514086956
Triglyceride biosynthesis	0	1	1.669528430300755	0.0950127008591197
Meiotic synapsis	13	20	1.66839445122145	0.0952374490520977
Adp signalling through p2y purinoceptor 1	6	9	-1.6678264665407945	0.0953501803246492
Ros and rns production in phagocytes	7	10	1.6676245471243374	0.0953902822022705
Synthesis of ip3 and ip4 in the cytosol	4	8	-1.6669975432168571	0.0955148933896252
Processing of smdt1	8	14	1.6640921097262258	0.0960940236153899
Phosphorylation of emi1	2	4	1.6638373110280331	0.0961449455205623
Stimuli sensing channels	8	19	-1.662953544810795	0.0963217349035752
G alpha s signalling events	9	15	-1.6613105198853666	0.0966510982993882
Runx2 regulates osteoblast differentiation	5	10	-1.6584108703411502	0.0972345639957128
Collagen degradation	4	4	-1.6536695563871924	0.0981946715050465
Complement cascade	3	5	-1.6523322563446885	0.0984668371160197
Rho gtpase cycle	85	247	1.647109609805544	0.099535518245206
Visual phototransduction	7	19	-1.6456709637835334	0.0998315201810751
Synthesis of dolichyl phosphate	3	5	-1.643228331937968	0.1003357000620404
Nectin necl trans heterodimerization	2	3	-1.642200217160795	0.100548517716984
Competing endogenous rnas cernas regulate pten translation	3	4	-1.6373914042137343	0.1015487131254921
Regulation of pten mrna translation	3	4	-1.6373914042137343	0.1015487131254921
Signaling by mst1	1	1	-1.637262167377966	0.1015757022989909
Activated tak1 mediates p38 mapk activation	7	11	-1.6354283676589196	0.1019592796920196
Signaling by tgf beta receptor complex in cancer	2	3	-1.6291569453031842	0.1032797987652693
Arms mediated activation	0	3	1.625308673189591	0.1040968043098216
Branched chain amino acid catabolism	9	19	1.6229644931779474	0.1045969953703385
Ikba variant leads to eda id	5	6	-1.6215980063706037	0.1048894498117292
Synthesis of epoxy eet and dihydroxyeicosatrienoic acids dhet	1	1	-1.6210332109056054	0.105010516335088
Biosynthesis of maresins	1	1	-1.6210332109056054	0.105010516335088
Transcriptional activation of mitochondrial biogenesis	9	25	-1.6209165778615646	0.1050355309806172
Acyl chain remodelling of pe	3	3	-1.618634718984063	0.1055258803378131
Glycogen metabolism	6	13	1.618547598506592	0.1055446376176965
The role of nef in hiv 1 replication and disease pathogenesis	11	16	1.616986864957288	0.1058811162398605
Erythrocytes take up carbon dioxide and release oxygen	1	1	-1.6152323707658316	0.1062603829165129
Esr mediated signaling	23	80	-1.614961360769084	0.1063190627090597
Late endosomal microautophagy	9	21	-1.61386773321931	0.1065561188606336
Maturation of sars cov 1 spike protein	3	5	1.6135673717656425	0.1066212988870534
Glutamate and glutamine metabolism	6	9	1.60681153352454	0.1080957174171635
Synthesis of glycosylphosphatidylinositol gpi	4	4	-1.6031454254577295	0.1089025510373078
Nf kb is activated and signals survival	4	5	-1.6012494772896266	0.1093216742290479
Regulated necrosis	8	28	1.6010534570092494	0.109365079625026
Antigen presentation folding assembly and peptide loading of class i mhc	10	22	1.6008232122121566	0.1094160808653905
Rhob gtpase cycle	15	46	-1.5976436588797738	0.1101223041941454
Perk regulates gene expression	10	18	1.5958357485315957	0.1105254696230326
Potassium channels	3	5	-1.5927474417684415	0.1112168600361431
Prostacyclin signalling through prostacyclin receptor	3	5	-1.5927474417684415	0.1112168600361431
Inwardly rectifying k channels	3	5	-1.5927474417684415	0.1112168600361431
Glucagon type ligand receptors	3	5	-1.5927474417684415	0.1112168600361431
Hiv transcription initiation	12	30	-1.5890446897684412	0.1120503035931426
Pyruvate metabolism	10	20	1.5887627760944651	0.1121139601299869
Adora2b mediated anti inflammatory cytokines production	7	18	-1.5865699290389903	0.1126100825606795
Dna damage bypass	17	34	1.584399179764787	0.1131029084682564
Met activates ptpn11	2	3	1.5739265962834088	0.1155044203873165
G beta gamma signalling through pi3kgamma	5	9	-1.5676812001066518	0.1169555512670645
Synthesis of very long chain fatty acyl coas	5	10	1.567031678090425	0.1171072872873084
Fceri mediated ca 2 mobilization	5	10	-1.5630712094625456	0.1180358465651989
Sumoylation of intracellular receptors	4	5	-1.5627808488018418	0.118104150240347
Synthesis of pips at the plasma membrane	8	23	-1.5607855295128756	0.1185743628165476
Neurotransmitter receptors and postsynaptic signal transmission	18	65	-1.5545610544828496	0.120050645184258
Gpcr ligand binding	8	19	-1.5471089533567133	0.1218369753290524
Akt phosphorylates targets in the nucleus	3	5	-1.5448116720981675	0.1223918231890155
Ngf stimulated transcription	4	7	-1.5424376431137148	0.1229672800202776
Fcgr activation	2	4	-1.5420346884621907	0.1230651643516569
Apc c cdc20 mediated degradation of cyclin b	8	14	1.5397172415396247	0.1236292922407031
Recycling of eif2 gdp	5	8	1.5357148017602371	0.1246083431823708
Retrograde neurotrophin signalling	7	10	1.5338614041221577	0.1250637528470004
Synthesis of pips at the early endosome membrane	7	12	-1.53368517012928	0.1251071238471295
Interleukin 10 signaling	2	3	-1.5324544748882811	0.1254103235632508
Transferrin endocytosis and recycling	9	13	1.5294338210474718	0.1261569334110999
Transport of connexons to the plasma membrane	3	9	-1.5286586997279474	0.1263490758576513
Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components	8	15	1.5286572538097356	0.126349434494704
Apc cdc20 mediated degradation of nek2a	8	15	1.5286572538097356	0.126349434494704
Slc mediated transmembrane transport	12	45	-1.5277431043199854	0.126576333478654
P38mapk events	5	7	-1.5164755900969724	0.1293991380470385
Activation of caspases through apoptosome mediated cleavage	3	4	-1.5098223061595244	0.1310887716700224
Transcriptional regulation by e2f6	12	22	-1.5028598754611644	0.1328751818521452
Tp53 regulates transcription of genes involved in cytochrome c release	7	8	-1.4986726616811343	0.1339585722806666
Ksrp khsrp binds and destabilizes mrna	8	16	1.4980531534113448	0.1341194410629858
Hiv life cycle	37	117	1.4944817763713016	0.1350497415780023
Extra nuclear estrogen signaling	14	28	-1.4855555903336015	0.1373967090747641
Alpha oxidation of phytanate	3	5	1.483168871207589	0.1380295494813861
Intra golgi and retrograde golgi to er traffic	79	141	1.4798078754107995	0.1389245263624623
Shc1 events in egfr signaling	3	4	-1.4712576165952176	0.1412214607164439
N glycan trimming and elongation in the cis golgi	4	4	-1.4689557683699552	0.1418447867532792
Caspase activation via dependence receptors in the absence of ligand	2	4	-1.4686092808093392	0.141938796128977
Insertion of tail anchored proteins into the endoplasmic reticulum membrane	7	14	1.4685065243305158	0.1419666853256243
L1cam interactions	29	59	1.466078326439491	0.1426269495219472
G2 phase	1	3	-1.465595426542281	0.1427585379607903
Formation of tubulin folding intermediates by cct tric	6	16	1.4649516027789986	0.1429341224698195
Circadian clock	12	23	-1.4612990686985532	0.1439333853443676
Estrogen stimulated signaling through prkcz	2	3	-1.4605847138130443	0.1441294438169118
Dna replication initiation	6	8	1.4596982057463694	0.1443730352501964
Runx2 regulates bone development	6	12	-1.4593021710191063	0.1444819581354719
Synthesis of substrates in n glycan biosythesis	11	30	-1.4588305592640582	0.1446117493896923
Activation of rac1 downstream of nmdars	2	5	-1.4571680225078645	0.1450700052578271
Trna processing	40	88	1.4551843276145238	0.1456182384869948
Arachidonic acid metabolism	6	10	1.450452346207174	0.1469324188070835
Rho gtpases activate pkns	10	26	1.447024916897424	0.1478899450809219
Surfactant metabolism	3	5	-1.4469639265304324	0.1479070271300377
Role of second messengers in netrin 1 signaling	0	2	1.4441562823100875	0.148695019220614
Prolonged erk activation events	4	8	1.4440836026829424	0.1487154599317652
Fatty acyl coa biosynthesis	9	21	1.4437593214466231	0.1488066882367333
Anti inflammatory response favouring leishmania parasite infection	10	29	-1.438105300622645	0.1504041788970054
Shc1 events in erbb2 signaling	3	6	-1.4316450099061004	0.1522454413506007
Synthesis of active ubiquitin roles of e1 and e2 enzymes	6	13	1.42744685912276	0.1534511322497631
Endosomal sorting complex required for transport escrt	21	22	-1.4243416983891783	0.1543475822994036
Ripk1 mediated regulated necrosis	6	15	1.422974907410416	0.1547434294548009
Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins	47	96	1.422848613225156	0.1547800453960339
Rab gefs exchange gtp for gdp on rabs	15	53	-1.4221372329656066	0.1549864158184728
Regulation of insulin secretion	9	25	-1.4203981109543655	0.1554918124610531
Myoclonic epilepsy of lafora	1	2	1.420008568050469	0.1556051866666417
Fructose metabolism	1	3	1.417815830722051	0.1562445410553339
Integration of provirus	5	8	1.4169731921796025	0.1564907654189387
Nade modulates death signalling	0	3	1.415058498092215	0.157051345164088
Rhod gtpase cycle	23	41	1.4115707782865383	0.158076381633146
Glutathione conjugation	14	18	1.4076371656395312	0.1592385364202277
Dual incision in tc ner	26	49	1.4031070674521633	0.1605849139872512
Pka activation in glucagon signalling	3	8	-1.402292793557856	0.1608278314959825
Potential therapeutics for sars	21	54	1.401439687408128	0.1610826313067672
Metabolism of fat soluble vitamins	6	12	-1.397370342021522	0.1623022329199313
Hiv elongation arrest and recovery	18	27	1.3954552624937138	0.162878596608381
Infection with mycobacterium tuberculosis	9	16	1.3941737952546585	0.1632651290912024
Response of mtb to phagocytosis	9	16	1.3941737952546585	0.1632651290912024
Hcmv infection	31	80	1.393555618566731	0.1634518385236414
Glycogen breakdown glycogenolysis	4	9	1.3831273743458925	0.1666258134109575
Signaling by nodal	4	6	-1.3786100148181288	0.1680150270925988
Notch3 intracellular domain regulates transcription	3	7	-1.3783637674031035	0.1680910042228904
Signalling to ras	6	9	-1.3768596804841242	0.1685556349689936
Rho gtpase effectors	99	182	1.3758978372662474	0.1688532649082073
Protein folding	22	53	1.372196413781518	0.1700023015332759
Abortive elongation of hiv 1 transcript in the absence of tat	13	19	1.371405161693091	0.170248689300051
O linked glycosylation	7	12	-1.371290256310075	0.1702844918962991
Vldlr internalisation and degradation	6	8	1.369876948180006	0.1707253166629727
N glycan trimming in the er and calnexin calreticulin cycle	10	22	1.3684025966534104	0.1711860919131902
Vegfr2 mediated cell proliferation	7	10	-1.3670823143193782	0.17159950606544
Degradation of the extracellular matrix	6	19	-1.3665624690618687	0.1717624877968839
Signaling by ctnnb1 phospho site mutants	4	9	1.3636776135381712	0.1726690527520018
Beta catenin phosphorylation cascade	4	9	1.3636776135381712	0.1726690527520018
Aberrant regulation of mitotic exit in cancer due to rb1 defects	7	13	1.3615706391622355	0.1733334264592689
Sensory perception	9	44	-1.3592216771292642	0.1740763542180143
Diseases of glycosylation	23	42	-1.3563627501672797	0.1749837790493518
Robo receptors bind akap5	2	5	-1.3502455732678125	0.1769372242159104
Oncogene induced senescence	5	13	-1.349956112254885	0.1770300610170316
Recognition of dna damage by pcna containing replication complex	11	26	1.349222308633857	0.1772655713039876
Transcriptional regulation by the ap 2 tfap2 family of transcription factors	6	13	-1.3474865836415646	0.1778235715269362
Notch3 activation and transmission of signal to the nucleus	4	7	-1.3451793704819686	0.1785673165281756
Fatty acid metabolism	48	85	1.3435336325523386	0.1790992432234066
Rsk activation	3	4	1.3429289019245767	0.1792949968098942
Transcriptional activity of smad2 smad3 smad4 heterotrimer	8	19	-1.34254424793833	0.1794195935060796
Transport to the golgi and subsequent modification	66	118	1.340265616488804	0.180159005690013
Deadenylation of mrna	12	22	1.3389386068329223	0.1805906600207656
Chylomicron assembly	2	4	-1.3382515569312687	0.1808144475771751
Nuclear receptor transcription pathway	5	8	-1.3362817156125208	0.181457210541601
Positive epigenetic regulation of rrna expression	17	42	1.3345693228264128	0.1820173439843122
Synthesis of pi	1	2	1.332011610678555	0.1828563732358403
Glyoxylate metabolism and glycine degradation	11	17	1.3302292748912423	0.183442741457027
Signaling by tgf beta receptor complex	14	38	-1.3262205560715774	0.1847666523315116
Regulation of tp53 activity	43	101	-1.322939418278907	0.185855525275387
Mrna editing	0	2	1.3228324343952569	0.1858911084628378
Signaling by erythropoietin	4	8	-1.321057443119576	0.1864822114856674
Synthesis of pips at the late endosome membrane	5	8	-1.3206318290206716	0.1866241546095408
Rhoh gtpase cycle	19	30	1.319642906159222	0.186954270466664
Platelet adhesion to exposed collagen	2	4	-1.3154400717962933	0.1883620456124557
Collagen formation	12	17	1.3132330631918203	0.1891044260223893
Formyl peptide receptors bind formyl peptides and many other ligands	2	3	1.3132163967987285	0.1891100403585424
Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps	11	27	1.3107873371130911	0.1899296218847099
Cooperation of pdcl phlp1 and tric cct in g protein beta folding	6	19	1.3104849800259688	0.1900318221022752
Antigen activates b cell receptor bcr leading to generation of second messengers	5	8	-1.309078417618274	0.1905077891645412
Translesion synthesis by polk	8	11	1.307268412365672	0.1911215681647571
Creb1 phosphorylation through the activation of adenylate cyclase	4	8	-1.3047219958981748	0.1919875287936088
Tp53 regulates transcription of death receptors and ligands	1	3	1.3025196577199616	0.1927388025004699
Atf4 activates genes in response to endoplasmic reticulum stress	8	15	1.2972956271758591	0.1945294884009323
Processing of intronless pre mrnas	12	21	1.2966386017414304	0.1947555640203155
Hdl assembly	1	3	-1.2965904198375338	0.1947721504946709
Pka mediated phosphorylation of key metabolic factors	1	3	-1.2965904198375338	0.1947721504946709
Foxo mediated transcription	7	21	-1.295168519401128	0.1952621020384706
Tnfr1 induced proapoptotic signaling	3	6	-1.2946261400811867	0.19544923038328
Activated ntrk2 signals through ras	2	3	-1.294211892955142	0.1955922398852756
Activated ntrk3 signals through ras	2	3	-1.294211892955142	0.1955922398852756
Shc1 events in erbb4 signaling	2	3	-1.294211892955142	0.1955922398852756
Shc mediated cascade fgfr4	2	3	-1.294211892955142	0.1955922398852756
Shc mediated cascade fgfr1	2	3	-1.294211892955142	0.1955922398852756
Shc mediated cascade fgfr3	2	3	-1.294211892955142	0.1955922398852756
Processive synthesis on the lagging strand	9	16	1.2922943226101544	0.196255237351401
Interferon gamma signaling	8	25	-1.2846591729112655	0.1989114110592766
Nucleotide excision repair	42	82	1.2832220062778594	0.1994143082831581
Gpvi mediated activation cascade	4	11	-1.282898478099437	0.1995276461208666
Estrogen dependent gene expression	14	51	-1.280931571319459	0.200217702367448
Piwi interacting rna pirna biogenesis	7	12	1.2799237675752848	0.2005719477689371
Nrif signals cell death from the nucleus	2	4	-1.2718002873721774	0.2034440868479179
Activation of kainate receptors upon glutamate binding	6	9	-1.267964823751489	0.2048105127357238
Defective intrinsic pathway for apoptosis	12	19	1.2646468707140144	0.2059979432164058
Biotin transport and metabolism	6	10	1.2625782713227205	0.2067407807986798
Sars cov infections	33	95	1.2597153785628792	0.2077720556536095
Response to elevated platelet cytosolic ca2	19	49	1.2576266506584493	0.2085268104273796
Oas antiviral response	2	4	1.2550831025658575	0.2094485938416936
Rho gtpases activate wasps and waves	12	26	1.251638518666004	0.2107016122687977
Adherens junctions interactions	4	9	1.2457286791951547	0.2128640210239527
Copii mediated vesicle transport	28	44	1.2455368118909786	0.2129344927928766
Urea cycle	1	3	-1.2452735803190125	0.213031203656937
G protein beta gamma signalling	7	13	-1.245061850378599	0.2131090159109481
Grb2 events in erbb2 signaling	2	3	-1.2445923841911906	0.2132816212401493
Activation of nmda receptors and postsynaptic events	12	44	-1.243646963278632	0.2136295236555425
Rna polymerase ii transcribes snrna genes	24	54	-1.2420274347948816	0.2142264399430737
Transport of vitamins nucleosides and related molecules	5	11	1.2396000325993717	0.2151233686039622
Mitochondrial translation	34	82	1.2393170097347377	0.215228121858138
Runx1 regulates estrogen receptor mediated transcription	2	2	-1.2342125749306088	0.2171237028391386
Cobalamin cbl vitamin b12 transport and metabolism	8	12	-1.229134374019752	0.2190214291222969
Intraflagellar transport	10	25	-1.226879642341152	0.2198678311055086
Hsf1 dependent transactivation	9	21	1.226109543227181	0.2201574550657588
Regulation of runx1 expression and activity	4	9	-1.2254001919760726	0.2204244746437871
Thrombin signalling through proteinase activated receptors pars	7	13	-1.223279093793746	0.2212243006441028
Arachidonate production from dag	2	3	1.2212758360160254	0.2219815992631111
Runx1 regulates expression of components of tight junctions	0	3	1.2197960993701502	0.2225421804485892
Metabolism of steroids	30	70	1.219412797281488	0.22268755515142
Regulation of cholesterol biosynthesis by srebp srebf	13	36	1.2183506749608162	0.2230907406303575
Trif mediated programmed cell death	2	3	-1.2178474221997349	0.223281959475341
Tlr3 mediated ticam1 dependent programmed cell death	2	3	-1.2178474221997349	0.223281959475341
Golgi associated vesicle biogenesis	25	44	1.2172430184966174	0.2235117671656803
Formation of tc ner pre incision complex	22	39	1.2156436241567952	0.2241207084321261
Diseases of dna repair	12	23	-1.2077035529796456	0.2271613108942065
Protein ubiquitination	18	37	1.2003551694268115	0.2300014319372485
Rac1 gtpase cycle	16	81	-1.1972303653029737	0.2312167774104994
Phosphate bond hydrolysis by nudt proteins	1	4	1.1961155048434655	0.231651487844557
Mapk targets nuclear events mediated by map kinases	7	17	-1.1937789099529343	0.2325644635804773
Attachment of gpi anchor to upar	4	5	1.1927865994454885	0.2329529595783475
Peptide hormone metabolism	11	30	-1.1911009842257292	0.2336139435477036
Tgf beta receptor signaling in emt epithelial to mesenchymal transition	3	7	-1.187938170906122	0.2348577698176068
Cargo concentration in the er	13	20	1.184997490350583	0.2360184391782549
Trafficking and processing of endosomal tlr	2	5	-1.1847381558928471	0.2361209913170681
Establishment of sister chromatid cohesion	6	10	1.1831379597157778	0.236754475821515
Respiratory electron transport	38	82	1.1821178572446116	0.2371589397847355
Transmission across chemical synapses	21	78	-1.180730594204338	0.2377097636684495
Biosynthesis of specialized proresolving mediators spms	1	3	1.1793182853166055	0.2382714597895672
Diseases of mitotic cell cycle	10	19	1.1786009503775916	0.2385571130320849
Antimicrobial peptides	5	7	-1.1629042825309426	0.2448683397030953
Hur elavl1 binds and stabilizes mrna	3	7	1.1622654993065953	0.2451276361510443
Telomere c strand synthesis initiation	3	6	1.162057331900563	0.2452121775770415
Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde	3	5	-1.161303746289524	0.2455183965511267
Neuronal system	24	95	-1.1605494590016092	0.2458251691280017
Downregulation of smad2 3 smad4 transcriptional activity	4	8	1.1602242816336543	0.2459575033338747
Signaling by fgfr2	11	32	1.157098089053431	0.2472322873328267
Signaling by fgfr	11	32	1.157098089053431	0.2472322873328267
Erk mapk targets	6	11	1.1555650165661806	0.2478591243164973
Caspase mediated cleavage of cytoskeletal proteins	4	9	1.152930600370054	0.2489388708709203
Laminin interactions	4	7	-1.1515240069827195	0.2495167246257827
Endogenous sterols	2	4	-1.1489347536649637	0.2505828857510781
Repression of wnt target genes	3	7	-1.1465451181054147	0.2515696699680672
Ecm proteoglycans	5	9	-1.1462790672578076	0.2516797013650398
Diseases of immune system	5	8	-1.1440291383490433	0.2526115530372614
Prolactin receptor signaling	3	6	-1.143243774168036	0.2529373922405638
Displacement of dna glycosylase by apex1	0	4	1.1322056201804456	0.2575479978375368
Akt phosphorylates targets in the cytosol	8	8	-1.1318258093408504	0.2577076747055231
Biological oxidations	34	66	1.131334612993527	0.2579142811405752
Tristetraprolin ttp zfp36 binds and destabilizes mrna	7	16	1.1302742345490548	0.2583606878693967
2 ltr circle formation	4	7	1.129917040884888	0.2585111826924056
Sulfide oxidation to sulfate	2	4	-1.1258173045762343	0.2602428579811269
Rho gtpases activate paks	8	15	1.1235790201975873	0.261191660490883
Apex1 independent resolution of ap sites via the single nucleotide replacement pathway	1	3	1.1232856317002295	0.261316204135432
Camk iv mediated phosphorylation of creb	3	6	-1.12135276689813	0.2621377329644148
Pentose phosphate pathway	5	11	1.1161633191680305	0.26435223249277
Formation of the beta catenin tcf transactivating complex	8	20	-1.1156703271520765	0.2645632764523093
Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol	2	6	-1.1105214887783776	0.2667743734952825
Attenuation phase	8	16	1.1089921386598551	0.2674335733394106
Amino acid transport across the plasma membrane	3	10	-1.107308916018308	0.2681603907945
Synthesis of diphthamide eef2	2	6	-1.1070450589359089	0.268274447507737
Nicotinate metabolism	3	8	-1.1011691711304152	0.2708230364911617
Disassembly of the destruction complex and recruitment of axin to the membrane	4	10	1.1005064893396352	0.2711115037547436
Scavenging by class b receptors	1	2	-1.0969474345025685	0.2726643713803796
Dna double strand break repair	19	92	1.0917504098742647	0.2749428213250651
Metabolism of folate and pterines	6	11	1.0894458107285925	0.275957339022951
Traf3 dependent irf activation pathway	5	7	-1.0885949004392053	0.2763325665912344
Constitutive signaling by akt1 e17k in cancer	4	12	-1.0868501509490698	0.277103039728253
Phenylalanine metabolism	2	3	1.0817291099524051	0.2793729143017949
Resolution of sister chromatid cohesion	40	99	1.0809887976419312	0.2797020967648844
Conversion from apc c cdc20 to apc c cdh1 in late anaphase	6	12	1.0805675819547742	0.2798895094250349
Interleukin 15 signaling	3	5	-1.076399027909141	0.2817488369376413
Plasma lipoprotein remodeling	2	4	-1.0742442767174636	0.2827132125799978
Sema3a plexin repulsion signaling by inhibiting integrin adhesion	2	7	-1.0738894877231924	0.2828722154170004
Interaction between l1 and ankyrins	2	4	1.0737873772453723	0.2829179886505928
Phenylalanine and tyrosine metabolism	4	5	1.0724558044753951	0.2835153545010653
Activated notch1 transmits signal to the nucleus	5	7	-1.0722339150358626	0.2836149807961117
Immunoregulatory interactions between a lymphoid and a non lymphoid cell	5	12	-1.0696543997103507	0.2847748990327066
Wnt5a dependent internalization of fzd4	6	12	1.068605344721294	0.2852475391935063
Muscle contraction	15	40	1.0684300348113656	0.2853265748376534
Crmps in sema3a signaling	5	11	-1.064911177121692	0.2869161265659448
Formation of atp by chemiosmotic coupling	8	14	1.0626469218459096	0.287942099791767
Sumoylation of transcription cofactors	8	25	-1.0555174143287138	0.2911887493055549
Processive synthesis on the c strand of the telomere	4	16	1.05502708770749	0.2914129363289968
Ldl remodeling	1	2	-1.0550189577713054	0.2914166544741614
Notch hlh transcription pathway	4	11	-1.0541768505408518	0.2918019565499818
Bicarbonate transporters	2	2	-1.052959343184835	0.2923596261562895
Rrna processing in the mitochondrion	3	10	-1.0493491715262602	0.2940174426810698
Sensory processing of sound	15	24	1.038027195481713	0.2992573941246887
Clathrin mediated endocytosis	38	90	1.037288144430635	0.2996015893214709
Ddx58 ifih1 mediated induction of interferon alpha beta	15	32	-1.0372591308391488	0.2996151070863835
Oncogenic mapk signaling	21	43	1.0342543653676073	0.3010172646581259
Ion homeostasis	9	15	1.0318054466835045	0.3021632672093255
Nod1 2 signaling pathway	14	14	-1.0305462400303316	0.302753657603354
Dna damage recognition in gg ner	11	27	1.0304722771199328	0.3027883596177871
Role of lat2 ntal lab on calcium mobilization	2	5	-1.0259616097358568	0.3049096801255482
Processing of capped intronless pre mrna	14	25	1.025742601914971	0.3050129277079874
Signaling by braf and raf1 fusions	18	35	1.0250113605153437	0.3053578272903268
Epigenetic regulation of gene expression	34	68	1.022977130070708	0.3063186591358386
Factors involved in megakaryocyte development and platelet production	37	69	1.0167640772958275	0.3092656749003779
Regulation of gene expression in beta cells	3	5	-1.016006064675005	0.3096264985657959
Synthesis of pe	4	6	-1.015707798965026	0.3097685530574399
Rhof gtpase cycle	9	33	-1.0153297133065595	0.309948685118629
Defects in cobalamin b12 metabolism	7	10	-1.0138162087198406	0.3106704595459493
Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation	2	4	1.011349344833136	0.3118492564862576
Suppression of phagosomal maturation	5	8	1.0095723014231266	0.3127002456281498
Pi3k akt activation	2	2	-1.0085133155995314	0.3132080985655783
Serine biosynthesis	2	5	-1.0084428034885509	0.3132419330026161
Mitotic spindle checkpoint	38	90	1.0081206293988076	0.3133965551973852
Tfap2 ap 2 family regulates transcription of growth factors and their receptors	2	3	-1.0046763946811383	0.3150526982026305
Uptake and function of anthrax toxins	4	7	-1.0042309556518374	0.3152673045555212
Molecules associated with elastic fibres	0	3	0.9974438123933954	0.3185491340552659
Elastic fibre formation	0	3	0.9974438123933954	0.3185491340552659
Tight junction interactions	4	5	-0.994970779613376	0.3197504762180205
Signaling by insulin receptor	15	22	0.9908826728113452	0.3217428740897596
Homologous dna pairing and strand exchange	15	32	-0.9905366575952056	0.3219118808268
Global genome nucleotide excision repair gg ner	32	62	0.9891028937967744	0.3226128019384688
Activation of puma and translocation to mitochondria	0	2	0.9879249664930564	0.3231893971045503
Regulation of tp53 activity through methylation	3	9	-0.98409542829941	0.3250685945510603
Traf6 mediated irf7 activation in tlr7 8 or 9 signaling	2	3	-0.9808721106588172	0.3266558122459502
Molybdenum cofactor biosynthesis	6	6	-0.978858286411056	0.3276500054332345
Wax and plasmalogen biosynthesis	3	5	0.9773930132048096	0.3283746206243334
Activation of anterior hox genes in hindbrain development during early embryogenesis	14	34	-0.9758567389280858	0.329135462865614
Meiosis	20	36	0.9738376414046452	0.3301371600620617
Runx1 regulates transcription of genes involved in differentiation of myeloid cells	4	4	-0.969757530217454	0.3321673666893097
Interleukin 20 family signaling	3	6	-0.9684100814544798	0.3328396065481773
The canonical retinoid cycle in rods twilight vision	2	3	-0.9665695335056672	0.3337592710936594
G2 m dna replication checkpoint	1	4	0.9657835625053852	0.3341524953127122
Traf6 mediated irf7 activation	5	8	-0.9653846519406816	0.3343521859900504
Phospholipid metabolism	33	89	-0.9650235352791836	0.3345330237443151
Polb dependent long patch base excision repair	2	8	0.9631745567803446	0.3354599312243691
Purine catabolism	5	10	0.9615879314914432	0.3362566361587356
Ret signaling	4	12	-0.9604374145153536	0.3368351153807982
B wich complex positively regulates rrna expression	11	27	0.9595694489683432	0.3372719511769215
Cargo trafficking to the periciliary membrane	13	28	0.9591405082100608	0.3374879658801961
Transcriptional regulation of pluripotent stem cells	3	4	-0.948583192555514	0.342832642602966
Phase ii conjugation of compounds	19	42	0.9475659421013384	0.3433504713501685
Dcc mediated attractive signaling	6	9	-0.942601371827534	0.3458848378921135
Trans golgi network vesicle budding	29	56	0.9422012181652822	0.3460896303724066
Detoxification of reactive oxygen species	7	14	0.942165730861935	0.3461077959557335
Sensory processing of sound by outer hair cells of the cochlea	11	17	0.941614843371052	0.3463898674563186
Translation of replicase and assembly of the replication transcription complex	10	10	-0.9405555655345996	0.346932661866369
Inla mediated entry of listeria monocytogenes into host cells	1	3	0.9371411068065656	0.3486859789544334
Propionyl coa catabolism	2	5	-0.9339120817416128	0.3503492461249187
Mitochondrial fatty acid beta oxidation of unsaturated fatty acids	3	5	0.9336143206512486	0.3505028755303043
Caspase activation via extrinsic apoptotic signalling pathway	2	9	-0.9287420850879708	0.3530227648323789
G2 m dna damage checkpoint	21	54	0.9267817694556462	0.3540398522048946
Regulation of tp53 activity through association with co factors	4	6	-0.9267015386894136	0.3540815184220702
Hiv transcription elongation	21	34	0.9251339206251962	0.3548962505659827
Egfr interacts with phospholipase c gamma	1	2	-0.9207858868749365	0.3571622247508712
Bbsome mediated cargo targeting to cilium	5	11	0.9192760877390148	0.3579511819105301
Lrr flii interacting protein 1 lrrfip1 activates type i ifn production	3	4	-0.9178812380423949	0.3586810451685569
Smooth muscle contraction	6	17	0.9154379237305544	0.3599617769978038
Maturation of protein 3a	1	2	-0.9131467304793116	0.3611653758763629
Chromatin modifying enzymes	38	132	-0.9085935446578342	0.3635647153135688
Translocation of slc2a4 glut4 to the plasma membrane	29	53	0.905407883766484	0.3652493406608919
Ephrin signaling	6	11	-0.905245493709952	0.3653353453344166
Acetylcholine regulates insulin secretion	4	5	-0.9051605626082556	0.3653803313980934
Miscellaneous transport and binding events	4	12	-0.904290301528082	0.3658414880742171
Activated ntrk2 signals through fyn	2	3	-0.8974829898726746	0.3694612461269633
Ptk6 regulates rho gtpases ras gtpase and map kinases	4	9	-0.8970707834584305	0.3696811476821187
Irf3 mediated activation of type 1 ifn	0	2	0.8944232827143082	0.3710954598260696
Runx1 regulates genes involved in megakaryocyte differentiation and platelet function	6	21	-0.8860197298914095	0.3756068955408593
Trna modification in the nucleus and cytosol	11	29	-0.8847335534963522	0.3763003543169367
Cd28 dependent pi3k akt signaling	5	7	-0.8775103519479086	0.3802094985968578
Transcriptional regulation of granulopoiesis	5	14	-0.8743097593186128	0.3819495859667237
Constitutive signaling by overexpressed erbb2	2	6	0.8722286156530261	0.3830836715235972
Reproduction	20	37	0.8665719717071967	0.3861765761578206
Cell junction organization	10	27	0.8658848492425506	0.3865533124111249
Phase i functionalization of compounds	9	22	0.863050227646611	0.3881098517004111
Glutamate neurotransmitter release cycle	2	6	-0.8630342892318085	0.3881186145390507
Creb phosphorylation	3	5	-0.8614038399653355	0.3890156618827263
Runx3 regulates cdkn1a transcription	0	2	0.8599660415543573	0.3898077619114832
Formation of rna pol ii elongation complex	22	45	0.8579176683437879	0.3909379272832571
Nicotinamide salvaging	2	5	-0.8552894320184421	0.3923909365644111
Metabolism of nitric oxide nos3 activation and regulation	4	9	0.8527782683942094	0.3937822773951609
Thromboxane signalling through tp receptor	3	9	-0.8489888369095954	0.3958875039238332
Ldl clearance	10	16	0.8484425472744428	0.3961915559371736
Signaling by fgfr2 iiia tm	8	13	0.8484346648499309	0.3961959441416878
Fgfr2 mutant receptor activation	8	13	0.8484346648499309	0.3961959441416878
Endosomal vacuolar pathway	3	7	-0.8483096886380862	0.396265523252201
Pink1 prkn mediated mitophagy	7	12	0.8470229094976576	0.3969823521210418
Rho gtpases activate rocks	10	13	0.8461441280822535	0.3974723460512444
Dna damage reversal	3	6	0.8408299267630921	0.4004432190732454
Hyaluronan metabolism	2	6	0.8348329670209101	0.4038117612599359
Hyaluronan uptake and degradation	2	6	0.8348329670209094	0.4038117612599363
Processing and activation of sumo	1	4	0.8324642900320977	0.4051469265872016
Interleukin 23 signaling	1	3	-0.8283622759402558	0.4074653639644263
Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members	1	2	-0.8236075432780291	0.4101625884731175
Activation of gene expression by srebf srebp	9	27	0.8229016075418368	0.4105639484814047
G1 s specific transcription	8	15	0.819038530861633	0.4127644305331153
Regulation of pten gene transcription	9	39	-0.8172094717939689	0.4138087305539288
Fcgamma receptor fcgr dependent phagocytosis	19	52	0.8160001151947874	0.4145000698282661
Clec7a dectin 1 induces nfat activation	2	4	-0.8117845930241099	0.4169152441877641
Estrogen dependent nuclear events downstream of esr membrane signaling	6	10	-0.8073125887614786	0.4194864130062516
Pi3k akt signaling in cancer	6	22	-0.8058159524353572	0.42034897849346
Condensation of prophase chromosomes	7	15	0.8037758879301777	0.4215264175362447
Other interleukin signaling	2	7	-0.8001094177697469	0.4236474051342109
Heparan sulfate heparin hs gag metabolism	5	11	-0.7979546194244508	0.4248968253769889
Regulation of mecp2 expression and activity	6	20	-0.7975694730722526	0.4251203719787966
Grb2 sos provides linkage to mapk signaling for integrins	1	4	0.7938609069410419	0.4272764102840432
Signaling by erbb2	6	22	-0.7937910369621503	0.4273170914356974
Glutathione synthesis and recycling	5	7	0.7935487654459877	0.4274581692701189
Early phase of hiv life cycle	6	11	0.7922819477230824	0.4281962952732936
Hdms demethylate histones	5	15	-0.791901132124788	0.4284183268047292
Negative regulation of met activity	4	13	-0.7917929376366055	0.4284814209643628
Erks are inactivated	4	8	0.789860330303965	0.4296093409855073
Notch2 activation and transmission of signal to the nucleus	2	4	-0.7887811973571596	0.4302399008922841
Retrograde transport at the trans golgi network	19	37	-0.788765197862988	0.4302492537709645
Regulated proteolysis of p75ntr	4	5	-0.7859941310749067	0.4318709254630117
Ikk complex recruitment mediated by rip1	7	7	-0.7841566094740995	0.4329482219311251
Shc related events triggered by igf1r	3	4	-0.782996347007967	0.433629257203304
Mecp2 regulates transcription factors	1	2	-0.7813381519708632	0.4346036366101349
Activation of the pre replicative complex	15	30	0.7802633880610862	0.4352358582350242
Signaling by alk	4	11	-0.7800496120184568	0.4353616736033543
Mrna decay by 5 to 3 exoribonuclease	13	14	0.7795707686973903	0.4356435673246674
Cell cell communication	15	45	0.7770035248776667	0.437156690703637
Eph ephrin signaling	20	48	0.776671848835607	0.4373523997238306
Signaling by bmp	2	3	-0.7760154531394058	0.4377398616971204
Signaling by vegf	18	56	-0.7748228402578792	0.4384443509491369
Transport and synthesis of paps	1	3	0.7734159307711831	0.4392762648302017
Irak1 recruits ikk complex	3	6	-0.7731780806756049	0.4394169965162402
Signaling by egfr	8	23	-0.7726484905983245	0.4397304385483069
Negative regulation of nmda receptor mediated neuronal transmission	11	11	-0.7708976639066086	0.4407675919285605
Gaba b receptor activation	3	9	-0.7702430531063901	0.4411557296241817
Trna processing in the mitochondrion	3	5	0.7682855539050006	0.4423175551982199
Cytosolic sulfonation of small molecules	2	9	-0.7680229237362932	0.4424735659643903
Methylation	5	11	0.7674189017092743	0.4428324938910868
Cardiac conduction	9	17	0.76540908890067	0.4440279824760065
Erbb2 regulates cell motility	2	4	-0.7650822552653282	0.4442225656024758
Complex i biogenesis	19	46	0.7579928921337746	0.4484552378890623
Vitamin b1 thiamin metabolism	1	2	-0.7560968234148373	0.4495911463903459
Glycerophospholipid catabolism	3	3	-0.7539580414797761	0.450874416805525
Other semaphorin interactions	0	2	0.7500943959578231	0.4531978544535697
Chaperone mediated autophagy	5	11	0.7490375432348585	0.4538345774450762
Signaling by met	8	32	-0.7485126360023788	0.4541510062026948
Signaling by fgfr2 in disease	8	16	0.7402920923855032	0.4591227780860349
Activation of ampk downstream of nmdars	4	13	-0.7380178155489487	0.4605036231189121
Signaling by ntrk3 trkc	4	8	-0.7330789530414734	0.463510276152475
Erythropoietin activates phospholipase c gamma plcg	1	3	-0.7287815758993053	0.4661352833366678
Cytochrome p450 arranged by substrate type	2	5	-0.7282154488545546	0.4664817103350407
Rhoc gtpase cycle	15	54	-0.7281636290401862	0.4665134272850273
Defective ripk1 mediated regulated necrosis	3	4	-0.7260614374878807	0.4678011079157911
Tp53 regulates transcription of dna repair genes	21	47	0.7210288428633859	0.4708917690911467
Sars cov 1 infection	9	27	-0.7208140541673295	0.4710239272680132
Activation of bad and translocation to mitochondria	4	11	0.720456636133212	0.4712438897631366
Sirt1 negatively regulates rrna expression	2	7	-0.7197529584223672	0.4716771132072577
Nucleotide catabolism	6	13	0.7179647725408104	0.4727790079381706
Coenzyme a biosynthesis	2	5	-0.7171600250414694	0.4732753618970493
Ticam1 rip1 mediated ikk complex recruitment	6	6	-0.7166494600182656	0.473590417908845
Diseases of carbohydrate metabolism	4	14	0.7147494664196329	0.4747638656820725
Parasite infection	14	39	0.7120940814508797	0.4764065190326765
Formation of apoptosome	5	8	-0.709376289132763	0.4780909977447356
Trafficking of glur2 containing ampa receptors	5	9	0.708130760814728	0.4788640587041721
Mitophagy	10	18	0.7080597763823399	0.4789081371005075
Sema4d induced cell migration and growth cone collapse	3	10	-0.705920876804223	0.4802373438987359
Rhoa gtpase cycle	22	81	-0.7017316185432684	0.4828465507249049
Activation of noxa and translocation to mitochondria	1	2	-0.7014719737348362	0.4830085190320785
Ras processing	3	9	-0.6987227580111726	0.4847253085813476
Signaling by retinoic acid	3	18	-0.6982154428771299	0.485042470198227
G beta gamma signalling through cdc42	4	8	-0.6967504388655986	0.4859589872154475
Vxpx cargo targeting to cilium	5	12	0.6964567194392	0.486142852869877
Map3k8 tpl2 dependent mapk1 3 activation	5	10	-0.6948305241612022	0.4871615165667902
Butyrate response factor 1 brf1 binds and destabilizes mrna	7	16	0.6944887395969874	0.4873757600739683
Glycogen synthesis	3	7	0.6932683640634131	0.4881411525919203
E2f enabled inhibition of pre replication complex formation	4	10	-0.6924263547148725	0.488669619937939
Diseases of metabolism	35	83	-0.6882382025568952	0.4913027902486764
Sensing of dna double strand breaks	3	6	0.687348991600693	0.4918628329971259
Integration of energy metabolism	10	38	-0.6865635587477172	0.4923577990314363
Ercc6 csb and ehmt2 g9a positively regulate rrna expression	10	19	0.6856706609366434	0.4929208118671189
Dna double strand break response	6	33	0.6842838430215374	0.4937959474436719
Myogenesis	3	8	0.682477103254444	0.4949373161100054
Senescence associated secretory phenotype sasp	16	31	0.6821985704089288	0.4951133985287017
Signaling by fgfr in disease	18	29	0.6800201354810741	0.4964917114934226
Telomere extension by telomerase	8	15	0.6793606206808896	0.496909394816875
Chl1 interactions	1	4	0.6765428699136983	0.4986960372995745
Ticam1 traf6 dependent induction of tak1 complex	1	2	0.672949676700934	0.5009793067130321
Irak2 mediated activation of tak1 complex	1	2	0.672949676700934	0.5009793067130321
Alpha protein kinase 1 signaling pathway	1	2	0.672949676700934	0.5009793067130321
Plasma lipoprotein assembly remodeling and clearance	6	27	-0.6718464990914165	0.5016814230100706
Nef mediated downregulation of mhc class i complex cell surface expression	3	7	0.6716177596461691	0.5018270691792399
Reactions specific to the complex n glycan synthesis pathway	2	4	-0.6713723766100367	0.5019833377657474
Formation of the early elongation complex	15	25	0.6710472084887401	0.5021904559765613
Pkmts methylate histone lysines	13	30	-0.6708123613041893	0.502340071717783
Rab geranylgeranylation	9	39	-0.6706818727690738	0.5024232131507147
Costimulation by the cd28 family	9	23	0.6688335190133686	0.5036016822991789
Gaba receptor activation	3	10	-0.6664686830088962	0.5051115744103032
Signaling by activin	3	5	-0.6537196720294527	0.5132924269089381
G alpha z signalling events	6	12	-0.6526003403761897	0.5140139660805025
Activation of smo	3	5	-0.6519833860279315	0.5144118901998314
Autophagy	28	93	-0.6513683531008444	0.5148087343858694
Rho gtpases activate cit	9	13	0.6499787353413959	0.5157059575005909
Linoleic acid la metabolism	2	4	-0.6494520035905874	0.5160462600309725
Cytochrome c mediated apoptotic response	6	10	-0.6484863987721065	0.5166704050681523
Interleukin receptor shc signaling	4	5	-0.6483741601607966	0.5167429789277675
Keratan sulfate keratin metabolism	6	11	-0.6471647589108208	0.5175253167594023
Tbc rabgaps	6	28	-0.6467924797852277	0.5177662601199939
Mapk1 erk2 activation	2	5	-0.6450383813928732	0.5189023133643849
Ras activation upon ca2 influx through nmda receptor	9	9	-0.6407231371604104	0.5217025789944167
Long term potentiation	9	9	-0.6407231371604104	0.5217025789944167
Regulation of signaling by cbl	1	8	0.6382525413660962	0.523309300036717
Nostrin mediated enos trafficking	0	2	0.6363150279439944	0.524571111872679
Regulation of tp53 expression and degradation	4	17	0.634624137427806	0.525673581858126
Ptk6 expression	0	2	0.6296066104486108	0.5289519975116088
Anchoring of the basal body to the plasma membrane	14	58	-0.6292026948705731	0.529216364812044
Metabolic disorders of biological oxidation enzymes	3	9	-0.6269051289797307	0.5307214250313443
Downregulation of erbb2 erbb3 signaling	2	4	-0.625606583467752	0.5315730195411392
Cell extracellular matrix interactions	4	10	0.622072054589239	0.5338944895243367
Abc transporters in lipid homeostasis	2	5	-0.618800550486218	0.5360477595305531
Kinesins	16	31	0.6176798992465552	0.5367863646151503
Rac3 gtpase cycle	11	59	-0.6147975995493132	0.5386883947657028
Binding and uptake of ligands by scavenger receptors	5	11	0.613781937252709	0.5393594348333115
Fasl cd95l signaling	1	3	-0.6126807891438969	0.54008742745506
Transport of inorganic cations anions and amino acids oligopeptides	8	20	-0.612189420556054	0.5404124403299146
Mtor signalling	6	25	-0.6062297359549562	0.5443622094317493
The activation of arylsulfatases	0	3	0.6057615802603817	0.5446730854551318
Nef and signal transduction	1	3	-0.6044534083010357	0.5455422366115716
Runx2 regulates genes involved in cell migration	4	4	-0.5964485990171086	0.5508755823404341
Mecp2 regulates neuronal receptors and channels	6	9	0.5961067422264705	0.5511039203484662
Gap junction trafficking and regulation	4	19	-0.5951345496483654	0.5517535357874477
Egfr transactivation by gastrin	2	4	-0.5924740619972088	0.5535331847149463
Vegfr2 mediated vascular permeability	6	15	0.5903350159124516	0.5549660681953805
Regulation of commissural axon pathfinding by slit and robo	2	3	-0.5898339844878611	0.5553019561395018
Rora activates gene expression	4	7	-0.5830611633424795	0.5598521267442158
Defects in vitamin and cofactor metabolism	8	17	0.5803974781842809	0.561646605355119
Traf6 mediated induction of tak1 complex within tlr4 complex	2	3	0.577895306468607	0.5633348042925639
Assembly and cell surface presentation of nmda receptors	17	18	-0.5775182706305485	0.5635893998713741
Netrin 1 signaling	10	20	-0.5762066605574806	0.5644755037359261
Metabolism of porphyrins	6	13	0.5753320607214095	0.565066742478316
Unblocking of nmda receptors glutamate binding and activation	8	8	-0.5733277668047391	0.5664227882552324
Tp53 regulates transcription of genes involved in g1 cell cycle arrest	1	3	0.5720140711718026	0.5673124418312518
Maturation of sars cov 2 spike protein	7	17	0.5713630270964921	0.5677535861524172
Platelet homeostasis	9	21	-0.5689756940914493	0.5693726348978443
Diseases of mismatch repair mmr	2	5	-0.5647391088559293	0.5722512291231843
Organelle biogenesis and maintenance	36	159	-0.5630590952135429	0.5733946441046962
Pi3k events in erbb2 signaling	1	2	-0.5541952127791818	0.5794452542252286
Gastrin creb signalling pathway via pkc and mapk	4	10	-0.553902933020053	0.579645277729322
Trafficking of ampa receptors	8	15	0.5499186126249664	0.5823751974263327
Sars cov 2 infection	8	42	-0.5489240641289193	0.5830575630207482
Negative regulation of mapk pathway	4	19	0.548271692585879	0.5835053613932835
Dna damage telomere stress induced senescence	10	26	0.5480434732144627	0.5836620526888943
Mismatch repair	9	16	0.5476588328576704	0.5839261841557228
Runx3 regulates p14 arf	1	4	-0.547653756923776	0.5839296701575292
Apoptotic factor mediated response	9	15	-0.5451892181453856	0.5856233861558429
Tp53 regulates transcription of cell cycle genes	8	26	0.5414880448540174	0.5881712356965241
Adrenaline noradrenaline inhibits insulin secretion	3	7	-0.5392548772135468	0.5897109992784808
Response of eif2ak1 hri to heme deficiency	2	5	0.5376321331830335	0.5908310415506475
Sos mediated signalling	1	2	-0.5337922294489403	0.5934852905070618
Signaling by fgfr3 fusions in cancer	1	2	-0.5337922294489403	0.5934852905070618
Inhibition of dna recombination at telomere	8	17	0.533734974381558	0.5935249080889831
Scavenging by class a receptors	3	6	-0.5337023979748359	0.5935474498387614
Signaling by leptin	1	3	-0.5332598476257459	0.5938537182347394
Free fatty acids regulate insulin secretion	1	5	0.5308043563661763	0.5955543609296083
Nucleotide salvage	4	12	0.5298538340597182	0.5962132767417816
Basigin interactions	3	10	0.5286744529912129	0.597031302152411
Platelet calcium homeostasis	2	6	0.5259429981189582	0.5989278125495079
Acyl chain remodelling of pc	2	5	-0.5246190601865837	0.5998480340212309
Interferon alpha beta signaling	3	15	-0.5234925450647553	0.6006315375380418
Signaling by kit in disease	4	10	-0.5221554515069785	0.6015621004429947
Integrin signaling	3	9	0.5200747824670039	0.6030114538477309
Platelet aggregation plug formation	3	9	0.5200747824670039	0.6030114538477309
Rhot1 gtpase cycle	1	3	-0.5169889886453519	0.6051638455423101
Ion transport by p type atpases	5	17	0.5169757492591848	0.6051730876452428
Interleukin 21 signaling	2	4	-0.5115761076701147	0.6089477104841674
Interleukin 9 signaling	2	4	-0.5115761076701147	0.6089477104841674
Post translational modification synthesis of gpi anchored proteins	12	12	-0.5085515312884109	0.6110666100007436
Ephb mediated forward signaling	3	24	0.5072378383117857	0.611987948593578
Ncam signaling for neurite out growth	7	13	-0.5072350870537508	0.6119898787914213
Aggrephagy	15	24	0.5051907122889312	0.6134248930309967
Fbxw7 mutants and notch1 in cancer	1	3	-0.5045271961814388	0.6138909558742878
Regulation of tlr by endogenous ligand	2	3	-0.5032222814037857	0.6148080010460037
Tp53 regulates transcription of caspase activators and caspases	4	5	-0.5018299917828237	0.6157871141914215
Rhoq gtpase cycle	12	41	-0.497571988022861	0.6187857516061486
Mrna capping	12	22	0.4952000937170067	0.6204588844793646
Tryptophan catabolism	1	3	-0.4927833269969002	0.6221656927861423
Interleukin 3 interleukin 5 and gm csf signaling	4	16	-0.4920077856546382	0.6227138396375564
Met receptor recycling	1	7	0.4896680973350838	0.6243687804669189
Metalloprotease dubs	4	11	-0.4874133246580582	0.6259654527373113
Cyclin a b1 b2 associated events during g2 m transition	8	16	0.4869390232113956	0.6263015435539177
Tgf beta receptor signaling activates smads	6	15	0.4830498776555214	0.6290603215839607
Downregulation of tgf beta receptor signaling	5	11	0.4794236025655717	0.6316373057871458
Suppression of apoptosis	5	6	0.4782851748339549	0.6324472466608675
Recruitment of mitotic centrosome proteins and complexes	16	58	-0.476458169197508	0.6337480018959192
Signaling by flt3 itd and tkd mutants	2	4	-0.476235826439332	0.6339063784674666
Stat5 activation downstream of flt3 itd mutants	1	3	-0.4759393490827084	0.6341175878119449
Stat5 activation	1	3	-0.4759393490827084	0.6341175878119449
Enos activation	2	6	0.4735876368576746	0.6357939933673897
Regulation of pyruvate dehydrogenase pdh complex	3	11	0.4726019023841992	0.6364972249844618
Inactivation of csf3 g csf signaling	3	9	-0.4675598747992873	0.6400993649403195
Interleukin 37 signaling	5	7	-0.4671407104907391	0.6403992092826716
Alpha linolenic omega3 and linoleic omega6 acid metabolism	3	9	0.4650291414983103	0.6419105878491647
Metabolism of steroid hormones	3	8	0.4605249309867535	0.6451394807359585
Signaling by csf3 g csf	4	12	-0.4583814800065339	0.6466783947932324
Tp53 regulates transcription of genes involved in g2 cell cycle arrest	5	13	0.452982792277934	0.6505611324688658
Degradation of cysteine and homocysteine	4	9	-0.4526989055028778	0.6507655678021389
Maturation of sars cov 2 nucleoprotein	2	8	-0.4518361482238962	0.651387026257932
Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	2	13	0.4482020550826325	0.6540073797065995
Assembly of the orc complex at the origin of replication	4	14	-0.4476723342506287	0.6543896908958546
Dna methylation	2	7	-0.4475426012258457	0.65448333590244
Met promotes cell motility	4	12	0.4465833154632107	0.6551759444565524
Amyloid fiber formation	3	13	-0.4450424545211619	0.6562890738448419
Cilium assembly	22	106	-0.4410435173254584	0.6591814928929953
Ra biosynthesis pathway	1	6	-0.4404106045744669	0.6596397457133345
Ovarian tumor domain proteases	4	15	0.4403063095705928	0.6597152715134298
Interleukin 2 family signaling	3	8	-0.431892259876566	0.6658197205568848
Formation of senescence associated heterochromatin foci sahf	6	14	0.4313734160696267	0.6661968762467525
Beta oxidation of very long chain fatty acids	3	9	-0.4308056061256397	0.6666097229354351
Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects	1	5	-0.4299840977645955	0.6672072089490506
P130cas linkage to mapk signaling for integrins	0	4	0.4291313745449638	0.6678276209123977
Metabolism of ingested semet sec mesec into h2se	0	3	0.4263947653834917	0.6698202150810308
Ionotropic activity of kainate receptors	3	3	-0.4217912408554393	0.6731773996518493
Nrcam interactions	3	3	-0.4217912408554393	0.6731773996518493
Downregulation of erbb4 signaling	3	3	-0.4103834281362469	0.6815247008404097
Microrna mirna biogenesis	4	17	0.4092130923187171	0.6823832872292812
Mucopolysaccharidoses	2	6	0.4076008111456486	0.6835667686980433
Formation of the cornified envelope	3	10	0.4014929177216614	0.6880572514053374
Keratinization	3	10	0.4014929177216614	0.6880572514053374
Synthesis secretion and inactivation of glucagon like peptide 1 glp 1	5	9	-0.3977692099360879	0.6908003154408051
Incretin synthesis secretion and inactivation	5	9	-0.3977692099360879	0.6908003154408051
Leishmania infection	18	73	-0.396219085847082	0.6919434125846415
Signal attenuation	2	5	-0.3943614832307345	0.6933141763287156
Bmal1 clock npas2 activates circadian gene expression	4	7	-0.3943438899010947	0.6933271636222509
Ketone body metabolism	5	6	0.3924640968067809	0.6947153343906209
Atf6 atf6 alpha activates chaperones	1	3	-0.3914860391245139	0.6954380060877119
Atf6 atf6 alpha activates chaperone genes	1	3	-0.3914860391245139	0.6954380060877119
Signaling by erbb4	5	15	-0.389834541478484	0.6966589000670398
Proton coupled monocarboxylate transport	1	3	-0.3890463792283208	0.6972418379650205
Regulation of plk1 activity at g2 m transition	14	62	-0.3852103035318405	0.7000816101708995
Notch4 activation and transmission of signal to the nucleus	1	3	0.3844500688339687	0.7006448968453154
Cell cell junction organization	4	14	0.3803940292662596	0.7036529460741439
Negative feedback regulation of mapk pathway	1	5	-0.37828236511814	0.7052208444159453
Eph ephrin mediated repulsion of cells	6	20	-0.3743730889838959	0.7081267615423585
Purine salvage	3	9	0.3733250581887017	0.7089065286477381
Methionine salvage pathway	1	6	0.3725126737591681	0.7095111776008858
Platelet sensitization by ldl	3	8	0.369718050028122	0.7115925813307586
Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants	2	5	0.3665702086308778	0.7139396336009272
Rho gtpases activate nadph oxidases	11	11	-0.3665081069347748	0.7139859643779669
Small interfering rna sirna biogenesis	6	6	-0.3636314704350366	0.7161332232872524
Pre notch processing in the endoplasmic reticulum	3	3	-0.3620925292378756	0.7172828862135683
Map2k and mapk activation	9	20	-0.3588472447789067	0.7197093670757855
Rna polymerase i transcription termination	19	19	-0.358368793181102	0.7200673423205004
Cd28 dependent vav1 pathway	3	7	0.3559558889429496	0.7218735998958357
Hs gag degradation	2	5	-0.3540406800295318	0.723308396833922
Uptake and actions of bacterial toxins	3	12	0.3516372534322997	0.7251103230924769
Sulfur amino acid metabolism	7	18	-0.3515715929416719	0.7251595722960453
Regulation of bach1 activity	3	6	-0.3514000345604271	0.725288256469125
Synaptic adhesion like molecules	4	9	0.3479384412166135	0.7278864149259157
Regulation of kit signaling	5	7	-0.3478369858137025	0.7279626113884445
Trafficking of myristoylated proteins to the cilium	1	4	-0.3465798726653442	0.7289069690393923
Interleukin 4 and interleukin 13 signaling	6	19	-0.3460158338698299	0.7293308152038007
Hs gag biosynthesis	3	3	-0.3435245106962971	0.7312039045939276
Carboxyterminal post translational modifications of tubulin	4	11	-0.3430377002344059	0.7315700983318698
Gap junction degradation	4	8	0.3411335128062441	0.7330030731896746
Cation coupled chloride cotransporters	2	2	-0.340768301387566	0.7332780155005618
Acyl chain remodelling of ps	1	3	-0.3400790011113669	0.7337970350184988
Purinergic signaling in leishmaniasis infection	2	7	0.3399380055099774	0.7339032148785938
Rhobtb3 atpase cycle	1	6	0.3386952433504717	0.7348393243571296
Growth hormone receptor signaling	3	8	0.3364222467191596	0.7365524757020905
Effects of pip2 hydrolysis	2	6	-0.3355598378169916	0.7372028143033529
Signaling by hippo	3	11	0.3344717026912183	0.73802364053832
Disinhibition of snare formation	3	4	0.3343306780880075	0.7381300432364091
Signaling by erbb2 in cancer	3	8	-0.3333263032170381	0.7388879864657014
Signaling by erbb2 ecd mutants	3	8	-0.3333263032170381	0.7388879864657014
Interleukin 7 signaling	2	5	-0.3333076586778872	0.7389020588151318
Pecam1 interactions	7	7	-0.3321671270167715	0.7397630646789926
G0 and early g1	1	11	0.3312719698272134	0.7404390619383863
Smac xiap regulated apoptotic response	3	5	-0.3262310052411957	0.7442495846812993
Miro gtpase cycle	4	6	0.3260844235099006	0.7443604817414422
Cd163 mediating an anti inflammatory response	2	3	0.3250000650394887	0.7451810224689677
Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain	5	7	-0.3237578859549149	0.7461213424028337
Vitamin b2 riboflavin metabolism	2	3	-0.3235632883767924	0.7462686855620002
Phase 0 rapid depolarisation	3	3	-0.3218957145166612	0.7475316998673176
Flt3 signaling in disease	2	10	0.3214107920749165	0.7478991057539701
Signaling by scf kit	4	16	-0.3208449184504949	0.7483279174392661
Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip	2	5	-0.3205551025573436	0.7485475663180874
Listeria monocytogenes entry into host cells	3	12	0.3181200015255462	0.7503939121071896
Mecp2 regulates transcription of neuronal ligands	2	4	0.317774680655604	0.7506558578593854
Constitutive signaling by ligand responsive egfr cancer variants	3	8	-0.3171693597887948	0.7511150979137557
Signaling by egfr in cancer	3	8	-0.3171693597887948	0.7511150979137557
Constitutive signaling by egfrviii	3	8	-0.3171693597887943	0.7511150979137562
Diseases associated with glycosaminoglycan metabolism	7	8	0.3138075677371322	0.7536671963028108
Signaling by pdgf	6	14	-0.3123128113994185	0.7548028045761104
Downstream signal transduction	6	14	-0.3123128113994173	0.7548028045761113
Cell surface interactions at the vascular wall	10	30	-0.3108678558260513	0.7559010818931662
Tak1 activates nfkb by phosphorylation and activation of ikks complex	8	13	-0.3107591625121864	0.7559837171485773
Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3	1	6	0.3102752279298977	0.7563516674620423
Intra golgi traffic	16	29	-0.3089630796915251	0.757349611820767
Downregulation of erbb2 signaling	3	10	0.3087319522819826	0.7575254359739982
Dscam interactions	1	5	-0.3078309501200586	0.7582109695973929
Spry regulation of fgf signaling	3	8	0.3037166851441292	0.7613437452192056
Negative regulation of fgfr1 signaling	3	8	0.3037166851441292	0.7613437452192056
Negative regulation of fgfr4 signaling	3	8	0.3037166851441292	0.7613437452192056
Negative regulation of fgfr3 signaling	3	8	0.3037166851441292	0.7613437452192056
Negative regulation of fgfr2 signaling	3	8	0.3037166851441292	0.7613437452192056
Netrin mediated repulsion signals	2	2	-0.3030808761702943	0.7618282277548931
Erythropoietin activates ras	2	5	-0.3025160035187648	0.7622587355788899
Recruitment of numa to mitotic centrosomes	17	63	-0.3022436905489307	0.7624663004427683
Diseases associated with o glycosylation of proteins	3	4	-0.2995994719054617	0.7644826870396588
Sialic acid metabolism	4	9	-0.2981502796676798	0.7655884679546785
Synthesis of ketone bodies	4	5	0.2945082851281911	0.7683695333872245
Heme biosynthesis	2	8	-0.2894346863110694	0.7722487544778807
The nlrp3 inflammasome	2	8	0.2892011926176912	0.7724274192516698
Inflammasomes	2	8	0.2892011926176912	0.7724274192516698
Cytosolic iron sulfur cluster assembly	5	11	-0.2836916690318352	0.7766466796995037
Calnexin calreticulin cycle	4	15	-0.2831944888930497	0.7770277527388554
Choline catabolism	2	3	-0.2820313242730233	0.7779194915332024
Interleukin 6 signaling	2	6	-0.2794469448091924	0.7799018486241007
Interleukin 6 family signaling	2	6	-0.2794469448091924	0.7799018486241007
Regulation of localization of foxo transcription factors	3	10	-0.2758891500448908	0.7826332076390945
Slbp dependent processing of replication dependent histone pre mrnas	2	6	-0.2756038706597754	0.7828523364148119
Signaling by pdgfr in disease	8	9	0.2753140719202632	0.7830749542375972
Nuclear events kinase and transcription factor activation	6	19	-0.2697173215294837	0.7873777336058239
Synthesis of pa	3	16	-0.2691848629400107	0.7877874281300583
Transcriptional regulation by tp53	48	222	-0.262141049261617	0.7932127002688973
Rhoj gtpase cycle	11	42	-0.260549809591741	0.7944396990978837
Hdr through single strand annealing ssa	13	29	-0.2578132900586048	0.796551007155617
Trna modification in the mitochondrion	5	9	0.2561982749182823	0.7977977406060415
Synthesis of pips at the er membrane	2	5	-0.2545756666168922	0.7990508553028222
Signal regulatory protein family interactions	4	5	0.2532675831264784	0.8000614445425989
Sumoylation of transcription factors	7	8	0.2530628327107102	0.800219659419237
Beta oxidation of pristanoyl coa	1	6	0.2528583233184053	0.8003776962356695
Metabolism of vitamins and cofactors	32	86	-0.2512415628075342	0.8016273523701083
Galactose catabolism	1	4	0.2471501124456182	0.8047920522592229
Mitochondrial biogenesis	13	53	-0.2456817813099495	0.8059285764251527
Syndecan interactions	1	8	0.2397550158782497	0.8105201820179635
Triglyceride catabolism	3	11	-0.2363651936093297	0.8131493025214394
Loss of mecp2 binding ability to the ncor smrt complex	2	4	-0.2344721282023338	0.8146184686157174
Met activates ptk2 signaling	3	7	-0.233398717030421	0.8154518093294707
Stat3 nuclear events downstream of alk signaling	2	6	-0.2301278603076142	0.8179924164082799
Adenylate cyclase inhibitory pathway	1	4	-0.2300945995354376	0.818018261268445
Irs mediated signalling	6	7	0.2294616914482627	0.8185100921118411
Release of apoptotic factors from the mitochondria	4	4	-0.2294345697830458	0.8185311698682964
Activated ntrk2 signals through frs2 and frs3	1	3	0.2289585463074591	0.8189011355609475
Frs mediated fgfr4 signaling	1	3	0.2289585463074591	0.8189011355609475
Frs mediated fgfr3 signaling	1	3	0.2289585463074591	0.8189011355609475
Frs mediated fgfr2 signaling	1	3	0.2289585463074591	0.8189011355609475
Frs mediated fgfr1 signaling	1	3	0.2289585463074591	0.8189011355609475
Lipophagy	2	6	-0.2264439797420633	0.8208561252394011
Budding and maturation of hiv virion	17	19	-0.2248405076937031	0.8221033521844494
Tie2 signaling	2	5	-0.2194400588815676	0.8263072678944647
Mtorc1 mediated signalling	4	16	-0.2152510335051944	0.8295716043329688
Prevention of phagosomal lysosomal fusion	3	5	0.2144908167424151	0.8301643275110497
Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10	4	9	-0.2107634771981926	0.8330718393087435
Nr1h2 nr1h3 regulate gene expression linked to lipogenesis	1	3	0.2074809711445648	0.8356342521664089
Glycogen storage diseases	4	5	0.2066146264987693	0.8363108364487195
Mitochondrial iron sulfur cluster biogenesis	6	6	-0.2037215447325009	0.8385711049920166
Type i hemidesmosome assembly	2	3	0.1995501661109187	0.8418324054475976
Vitamin b5 pantothenate metabolism	4	10	-0.1971380039532527	0.8437195440833829
Peroxisomal lipid metabolism	5	20	-0.1958935608208608	0.8446934773480979
Pyrimidine salvage	3	4	0.1952471315850576	0.845199483327032
Triglyceride metabolism	3	12	-0.1899283236356405	0.8493652973679118
Activation of irf3 irf7 mediated by tbk1 ikk epsilon	3	3	-0.1887115436882393	0.8503189035987087
Semaphorin interactions	6	33	-0.1829643242073025	0.854826011206324
Regulation of pten localization	1	4	-0.1828585376056064	0.8549090164866782
Negative regulation of the pi3k akt network	10	25	-0.181926208909131	0.8556406359753312
Rnd1 gtpase cycle	9	27	-0.1798218458875618	0.8572924326359737
Dissolution of fibrin clot	1	4	-0.1763722154292912	0.8600015313530414
Activation of ppargc1a pgc 1alpha by phosphorylation	4	4	-0.1758338906521222	0.8604244435334092
Signaling by mras complex mutants	3	6	-0.1755867610424918	0.8606186039136747
Synthesis of leukotrienes lt and eoxins ex	3	4	0.1737936371921071	0.8620276450829343
O linked glycosylation of mucins	2	7	-0.1731000255292557	0.8625728048850285
Regulation of ifng signaling	3	7	-0.172198260054667	0.8632816657254989
Foxo mediated transcription of oxidative stress metabolic and neuronal genes	4	8	-0.1709946154166707	0.8642279995162694
Sema3a pak dependent axon repulsion	2	11	-0.1693376545307538	0.865531059604441
Receptor mediated mitophagy	4	7	-0.166736292454751	0.8675775479955241
Loss of function of mecp2 in rett syndrome	9	9	-0.1574581167462766	0.8748838140764319
Class a 1 rhodopsin like receptors	4	11	-0.1517199280111247	0.8794078388507636
Peptide ligand binding receptors	4	11	-0.1517199280111247	0.8794078388507636
Regulation of ifna signaling	2	5	-0.1511341009655099	0.8798699327728763
Sema4d in semaphorin signaling	3	13	-0.1509746347467514	0.8799957250610952
Transcriptional regulation by mecp2	8	27	-0.148327877480363	0.8820840156482148
Synthesis of pips at the golgi membrane	2	12	-0.1475526894664593	0.8826957946185188
Egfr downregulation	3	13	-0.1462587819964284	0.88371710308768
Prc2 methylates histones and dna	2	12	-0.1435712784899653	0.8858390220876624
Diseases associated with glycosylation precursor biosynthesis	6	14	-0.1428482606469696	0.8864100214014794
Mitochondrial fatty acid beta oxidation	10	27	-0.1424287397940368	0.886741362715072
Interleukin 35 signalling	2	5	-0.1423656968386783	0.8867911563164026
Interleukin 27 signaling	2	5	-0.1423656968386783	0.8867911563164026
Pregnenolone biosynthesis	1	6	-0.1414988070912544	0.8874759023650982
Formation of incision complex in gg ner	6	26	-0.140809263724213	0.8880206245916595
Meiotic recombination	5	20	-0.1381572307965728	0.8901161557559323
Zbp1 dai mediated induction of type i ifns	5	10	-0.1370366030712281	0.8910018629511873
Signaling by ntrk2 trkb	4	9	-0.1362823333801871	0.8915980894959152
Acyl chain remodelling of pg	1	3	-0.1360719898937883	0.8917643703714655
Neurotransmitter release cycle	3	11	-0.1277901686679081	0.8983150305385224
Runx1 interacts with co factors whose precise effect on runx1 targets is not known	6	25	-0.1273552226857247	0.8986592547035777
Mapk3 erk1 activation	2	6	-0.1248006935591137	0.9006813383053385
Caspase activation via death receptors in the presence of ligand	1	5	-0.1219366255519725	0.9029492090469732
Regulation by c flip	1	5	-0.1219366255519725	0.9029492090469732
Synthesis of udp n acetyl glucosamine	1	6	-0.1199913500023372	0.904490000148201
Creb1 phosphorylation through nmda receptor mediated activation of ras signaling	14	14	-0.119326526759141	0.9050166683246664
Amino acids regulate mtorc1	7	23	-0.1162986999327237	0.9074158159254546
Gp1b ix v activation signalling	1	4	-0.116044883412355	0.9076169702399588
Polo like kinase mediated events	9	9	-0.112363236585972	0.9105354036401884
Tnfr1 induced nfkappab signaling pathway	7	12	-0.1114458990474837	0.9112627645496802
Gaba synthesis release reuptake and degradation	1	4	-0.1091742491861196	0.9130642843774426
P75ntr negatively regulates cell cycle via sc1	1	3	-0.1086687857766698	0.9134652005419266
Rna polymerase iii transcription initiation from type 3 promoter	11	12	-0.0966622552578059	0.9229946153568482
Downstream signaling of activated fgfr3	2	5	-0.0931950288296368	0.9257486236222444
Downstream signaling of activated fgfr4	2	5	-0.0931950288296368	0.9257486236222444
Downstream signaling of activated fgfr1	2	5	-0.0931950288296368	0.9257486236222444
Downstream signaling of activated fgfr2	2	5	-0.0931950288296368	0.9257486236222444
Non integrin membrane ecm interactions	6	12	-0.0910987946708697	0.927414090375336
Rnd3 gtpase cycle	9	28	-0.0887452360059471	0.9292843812041784
Pre notch processing in golgi	3	8	-0.0878986875896298	0.929957199720175
Fanconi anemia pathway	8	14	-0.0718366493202586	0.9427319062111564
Sema4d mediated inhibition of cell attachment and migration	4	4	-0.0700579219847749	0.9441475577633625
Dex h box helicases activate type i ifn and inflammatory cytokines production	2	5	-0.069530535090068	0.9445673279737364
Regulation of cytoskeletal remodeling and cell spreading by ipp complex components	2	4	-0.0552712262225341	0.9559223852617365
Translation of sars cov 2 structural proteins	7	26	-0.0523942077504205	0.958214589325457
Adp signalling through p2y purinoceptor 12	2	8	-0.0490549058871379	0.9608755400010104
Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways	19	22	-0.0460309630597403	0.9632855711052736
Nuclear signaling by erbb4	4	8	-0.041501983208406	0.9668957118462608
Rhov gtpase cycle	9	28	-0.0404942771467637	0.9676990694764184
Egr2 and sox10 mediated initiation of schwann cell myelination	3	12	-0.0391870482515251	0.9687412597038916
Synthesis of bile acids and bile salts	2	12	-0.0307242984110861	0.9754894129778716
Bile acid and bile salt metabolism	2	12	-0.0307242984110861	0.9754894129778716
Tp53 regulates metabolic genes	13	59	-0.0300072941598482	0.976061235893249
Signalling to erks	6	17	-0.0262351661029867	0.9790697670344026
Regulation of tp53 activity through phosphorylation	22	58	-0.0120409308155939	0.9903929593496572
Class i peroxisomal membrane protein import	2	16	-0.0081281181580793	0.993514771422547
Synthesis of pc	5	10	-0.0059937070837155	0.9952177422893348
Noncanonical activation of notch3	3	3	-0.0011248959590767	0.9991024630710325
Aflatoxin activation and detoxification	3	6	-0.0002700514051645	0.999784530155815
Membrane trafficking	51	405	0.0	1.0
Assembly of collagen fibrils and other multimeric structures	3	5	0.0	1.0
Wnt mediated activation of dvl	1	5	0.0	1.0
Role of phospholipids in phagocytosis	2	7	0.0	1.0
Generation of second messenger molecules	8	8	0.0	1.0
Intracellular signaling by second messengers	30	141	0.0	1.0
Vitamin d calciferol metabolism	2	6	0.0	1.0
Hemostasis	43	200	0.0	1.0
Intrinsic pathway for apoptosis	13	35	0.0	1.0
Recognition and association of dna glycosylase with site containing an affected purine	1	6	0.0	1.0
Raf independent mapk1 3 activation	1	9	0.0	1.0
E2f mediated regulation of dna replication	4	17	0.0	1.0
Activation of bh3 only proteins	4	17	0.0	1.0
Transcription of e2f targets under negative control by dream complex	5	8	0.0	1.0
Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1	4	6	0.0	1.0
Extracellular matrix organization	14	50	0.0	1.0
Synthesis of pg	1	5	0.0	1.0
Glycerophospholipid biosynthesis	15	51	0.0	1.0
Gamma carboxylation hypusine formation and arylsulfatase activation	2	15	0.0	1.0
Sphingolipid de novo biosynthesis	3	18	0.0	1.0
Signaling by ntrks	11	51	0.0	1.0
Transcription of the hiv genome	19	50	0.0	1.0
Signaling by flt3 fusion proteins	3	8	0.0	1.0
Activation of atr in response to replication stress	8	34	0.0	1.0
Darpp 32 events	2	13	0.0	1.0
Gab1 signalosome	3	6	0.0	1.0
Rnd2 gtpase cycle	7	27	0.0	1.0
Rip mediated nfkb activation via zbp1	4	9	0.0	1.0
Cytosolic sensors of pathogen associated dna	14	34	0.0	1.0
Signaling by cytosolic fgfr1 fusion mutants	2	12	0.0	1.0
Fgfr1 mutant receptor activation	13	14	0.0	1.0
Translation of sars cov 1 structural proteins	3	11	0.0	1.0
Metabolism of water soluble vitamins and cofactors	22	64	0.0	1.0
Integrin cell surface interactions	3	8	0.0	1.0
Synthesis secretion and deacylation of ghrelin	1	4	0.0	1.0
Signaling by type 1 insulin like growth factor 1 receptor igf1r	4	10	0.0	1.0
Rna polymerase i transcription	6	40	0.0	1.0
Rna polymerase ii transcription	101	520	0.0	1.0
Rna polymerase iii chain elongation	10	11	0.0	1.0
Rna polymerase i promoter escape	5	24	0.0	1.0
Rna polymerase i transcription initiation	32	34	0.0	1.0
Cyclin d associated events in g1	4	17	0.0	1.0
Chromosome maintenance	13	75	0.0	1.0
Mitotic prometaphase	31	153	0.0	1.0
Protein protein interactions at synapses	4	22	0.0	1.0
Neurexins and neuroligins	3	13	0.0	1.0
Peroxisomal protein import	7	36	0.0	1.0
Processing of dna double strand break ends	12	48	0.0	1.0
Nonhomologous end joining nhej	9	29	0.0	1.0
Homology directed repair	17	70	0.0	1.0
Signaling by moderate kinase activity braf mutants	8	22	0.0	1.0
Dna repair	47	186	0.0	1.0
Base excision repair ap site formation	1	8	0.0	1.0
Rna polymerase iii transcription termination	10	12	0.0	1.0
Metabolism of cofactors	6	11	0.0	1.0
Rac2 gtpase cycle	9	57	0.0	1.0
Plasma lipoprotein clearance	4	20	0.0	1.0
Rhou gtpase cycle	9	30	0.0	1.0
Inlb mediated entry of listeria monocytogenes into host cell	1	9	0.0	1.0
E3 ubiquitin ligases ubiquitinate target proteins	8	26	0.0	1.0
Cargo recognition for clathrin mediated endocytosis	11	57	0.0	1.0
Aurka activation by tpx2	11	54	0.0	1.0
Transcriptional regulation by ventx	5	22	0.0	1.0
Met activates ras signaling	2	6	0.0	1.0
Signaling by ptk6	8	22	0.0	1.0
Rna polymerase iii transcription initiation from type 1 promoter	18	18	0.0	1.0
Platelet activation signaling and aggregation	9	93	0.0	1.0
Insulin receptor signalling cascade	3	11	0.0	1.0
Rna polymerase iii transcription	5	20	0.0	1.0
Hdr through homologous recombination hrr	17	44	0.0	1.0
Raf activation	9	21	0.0	1.0
Rho gtpases activate formins	13	101	0.0	1.0
Signaling by fgfr1 in disease	15	16	0.0	1.0
Epha mediated growth cone collapse	4	14	0.0	1.0
Signal amplification	13	14	0.0	1.0
Regulation of glycolysis by fructose 2 6 bisphosphate metabolism	1	6	0.0	1.0
Striated muscle contraction	3	9	0.0	1.0
Post chaperonin tubulin folding pathway	2	14	0.0	1.0
Ctla4 inhibitory signaling	5	13	0.0	1.0
Cd28 co stimulation	6	16	0.0	1.0
Deactivation of the beta catenin transactivating complex	16	16	0.0	1.0
Diseases of programmed cell death	5	39	0.0	1.0
Nephrin family interactions	6	14	0.0	1.0
Hdacs deacetylate histones	9	24	0.0	1.0
Regulation of innate immune responses to cytosolic dna	3	6	0.0	1.0
Insulin processing	5	18	0.0	1.0
The phototransduction cascade	1	8	0.0	1.0
Selective autophagy	12	52	0.0	1.0
Signaling by receptor tyrosine kinases	35	187	0.0	1.0
Constitutive signaling by aberrant pi3k in cancer	9	10	0.0	1.0
Activation of rac1	9	9	0.0	1.0
Role of abl in robo slit signaling	2	6	0.0	1.0
Signaling by fgfr4 in disease	1	3	0.0	1.0
Signaling by fgfr4	4	11	0.0	1.0
Signaling by fgfr3	4	11	0.0	1.0
Signaling by fgfr1	4	11	0.0	1.0
Traf6 mediated nf kb activation	7	12	0.0	1.0
Negative regulators of ddx58 ifih1 signaling	6	13	0.0	1.0
Vesicle mediated transport	51	413	0.0	1.0
Rho gtpases activate iqgaps	2	17	0.0	1.0
Pyroptosis	1	13	0.0	1.0
Metabolism of lipids	99	320	0.0	1.0
Negative epigenetic regulation of rrna expression	8	40	0.0	1.0
Synthesis of gdp mannose	1	4	0.0	1.0
Asparagine n linked glycosylation	36	188	0.0	1.0
Signal transduction by l1	15	16	0.0	1.0
Lysosome vesicle biogenesis	6	24	0.0	1.0
Inactivation of cdc42 and rac1	2	5	0.0	1.0
Ion channel transport	13	46	0.0	1.0