Term es nes pval sidak fdr geneset_size leading_edge Metabolism of rna 0.41275220093311576 8.34274352089459 7.258648547158943e-17 1.0964386335266225e-13 1.0964386335266828e-13 568 O94906,Q9UNX4,Q9BY77,Q9BUQ8,Q8IWA0,Q14690,Q02543,P24928,P25788,P26373,P08865,O75691,Q9UKF6,P38919,Q01780,P49790,Q96DI7,Q92499,Q15366,P62753,P62826,Q14137,Q9Y2P8,Q15365,P36578,Q9NRG9,Q10570,P83731,P62917,P62701,P18077,Q13895,P26599,P25786,Q9BVI4,O00487,Q9H0A0,Q9BVP2,O43143,Q9Y3B4,Q8WWY3,Q15269,Q13200,P84103,P62263,Q99714,Q92979,Q8IY81,P62333,Q9UBU9,Q99460,Q92900,Q8TEM1,Q53GS9,P48556,Q00839,P63173,O75643,P07814,P23396,P09651,O75832,Q9BXP5,Q8IWX8,Q13435,Q04637,Q8TEQ6,Q12996,P42285,Q9UNM6,Q9Y4W2,P18621,P62910,P62899,P46778,P46776,P14866,P08708,P17980,P62750,Q9Y2X3,Q9Y2L1,Q92797,Q8WUM0,O43809,P78406,P40429,Q9Y3I0,P62318,Q12788,P61313,P25789,P62244,P62847,P61353,P30050,P25787,P18124,Q9Y5J1,Q8IYB3,Q15393,P62316,P62280,P28066,Q9UMS4,Q9H0S4,O00232,Q9UQ35,P05388,P50914,P62081,Q9H8H0,O00541,P62888,Q9Y2R4,P62487,P15170,O00567,P32969,P62913,Q9NW13,Q9BQ52,P84098,P62829,P62424,P43686,P46781,Q02878,P46087,P39019,P62495,O43660,Q6P2E9,Q5RKV6,P46779,P49207,P62851,P22087,P09661,Q9UKX7,Q9NR30,Q15061,Q8NI36,Q13838,P46777,P35998,P62277,P62249,O14818,Q969X6,Q07020,P62241,P15880,O60832,P61247,P60842,P62269,Q15029,Q14692,P62304,Q99436,Q9H4L4,Q7Z3B4,Q13151,P52948,P51991,P12270,P52597,P30153,P60900,P11940,P07910,P61289,O43242,P28074,O75533,Q8N1F7,P22626,O00231,P31946,P49720,Q96I25,O75400,Q9NYH9,Q7L014,P35637,P20618,Q92973,Q9UHX1,P49721,Q6PGP7,P28070,Q92945,P55795,P31943,Q14103,Q9BTX1,P38159,P26368,O43390,P61978,Q7L0Y3,Q15637,P11142,P51665,P17844,P62266,P47914,Q86XP3,Q15717,Q15459,Q8IZL8,Q9H583,Q8IX12,P55265,Q9BVJ6,P56182,Q08211,P63104,P35268,P27635,Q99459,Q08J23,P26196,P19338,Q9H0D6,O75694,O43172,A5YKK6,Q9NZI8,Q9NXF1,P62195,P62906,P39023,O14744,P05387,O43290,P62191,P52272,Q16637,P30876,Q99567,Q9Y450,P46783,P57678,Q12874,P49792,Q9Y3U8,Q9UHI6,Q96FV9,P57740,P35658,Q92621,P62995,O00425,O15042,Q9HCS7,Q9BW27,Q99848,Q15008,Q07955,O75494,O14980,P82979,Q13242,O00267,Q6P2Q9,Q12769,P42766,P08621,Q8WYA6,Q09161,Q9UL46,Q5SY16,Q05519,Q9Y224,O00566,Q9NX24,Q9NRX1,Q16629,Q06323,Q8TED0,Q8WUA2,Q8N684,Q15477,Q969T7,Q13573,P46782,P83881,P23588,Q8NI27,P09012,Q2NL82,P63151,Q99575,P78346,P60866,P61927,Q13243,O60231,Q96J01,Q13601,Q9BQA1,O43447,Q9NY93,P25398,O75934,O60306,Q15427,Q9BUJ2,Q9Y2W2,Q5SRE5,Q8IY37,P78316,Q9Y3A2,Q9Y5S9,O75940,Q9BV38,Q8NFH4,O95453,Q96F86,P37198,Q7RTV0,P62861,Q9GZS3,Q6UN15,O75937,P28072,Q9Y221,Q15024,Q9Y6V7,P61513,Q9NW64,O75152,Q9NQT5,Q86U42,Q9NY12,Q9Y333,Q9BZJ0,O43395,P41223,Q9Y6M1,Q68CQ4,P62314,P33240,Q15428,P62857,O15213,Q92620,O43592,Q9NQT4,Q13868,O15091,Q92600,Q86W42,Q9H6R4,Q13247,P18074,Q9BVL2,Q96C86,Q96EE3,P51003,Q9GZL7,P09234,O00148,Q01105,Q05048,Q52LJ0,P54105,Q5VV42,P67809,P08579,P62312,Q9NXG2,P55769,P19447,P06730,P52756,Q9P2I0,O43818 Regulation of expression of slits and robos 0.5813506111941061 6.7307594949128005 1.6877974873761193e-11 2.5148183735900825e-08 1.257409202595209e-08 136 P05387,P62191,P46777,Q02543,P25788,P26373,P08865,P35998,P62277,P62249,P62861,P38919,P46783,O14818,Q9Y3U8,Q07020,P62241,P15880,P28072,P61247,P62753,P62269,P36578,P83731,Q99436,P62701,P62917,P18077,Q15008,P25786,O00487,P60900,P11940,Q13200,P61289,P62263,O43242,P28074,P62333,Q13617,P42766,O00231,Q99460,Q09161,Q9UL46,P48556,P49720,P63173,P23396,O75832,Q04637,Q9UNM6,P18621,P62910,P62899,P46778,P46776,P20618,P08708,Q06323,P17980,P62750,P49721,P28070,P46782,P83881,P40429,Q15370,P61313,P25789,P62244,P62847,P61353,P30050,P25787,P18124,P60866,P62280,P28066,P61927,O00232,P05388,P51665,P50914,P25398,P62081,P62266,P47914,P62888,P15170,O94813,P32969,P62913,P84098,P35268,P27635,P62424,P62829,P43686,P46781,Q02878,P39019,P62495,Q9Y5S9,P46779,P49207,P62851,P62195,P62906,P39023 Eukaryotic translation initiation 0.6090084269360323 6.570030710182439 5.030488574549042e-11 7.495427844359393e-08 2.4984760416926906e-08 106 Q14232,P05387,P46777,Q02543,P26373,P08865,P05198,P62277,P62249,P62861,P46783,Q9Y3U8,Q07020,P62241,O00303,P15880,P61247,O15371,P62753,P60842,P62269,Q15056,P20042,P36578,P61513,P83731,P62917,P62701,P18077,P60228,P11940,Q14152,P62263,Q9NR50,P42766,O60841,P63173,P56537,P23396,O75821,P49770,O15372,Q9Y262,Q04637,P18621,P62910,P62899,P46778,P46776,P08708,P62750,Q7L2H7,P55010,P46782,P83881,P40429,P23588,O75822,Q13144,P61313,P62244,P62847,P61353,P30050,P18124,P60866,P62280,P61927,Q9UBQ5,P05388,P55884,P50914,P25398,P62081,P62266,P47914,P62888,P32969,P62913,Q13347,P84098,P35268,P62424,P27635,P62829,P46781,Q02878,P39019,P46779,P49207,P62851,P62906,P39023 Influenza infection 0.5603682133531726 6.514815517537175 7.277904906005434e-11 1.084407787137254e-07 2.7110196147370242e-08 137 P52294,P05387,Q9UKX7,P30876,P46777,P37198,Q02543,Q99567,P24928,P26373,P08865,P46783,P62277,P62249,P62861,P49792,P27824,P49790,Q00610,Q9Y3U8,Q07020,P62241,P15880,P61247,O00410,P62753,P57740,P62826,P62269,P27797,P35658,Q92621,P36578,Q9NRG9,P61513,P83731,P62917,P62701,P07900,Q7Z3B4,Q9BW27,P18077,P52948,O14980,P12270,P62263,Q8N1F7,Q12769,P42766,Q8TEM1,P12236,Q12849,P63173,P23396,P19525,P18621,P62910,P62899,P46778,P46776,P08708,P62750,Q8WUM0,P09874,P46782,P83881,P78406,P40429,P61313,P62244,P62847,P61353,P30050,P18124,Q9BTX1,P60866,P62280,P52292,P61927,P05388,P50914,P25398,P62081,P62266,P47914,P62888,Q13217,P62487,P32969,P62913,P84098,P35268,Q5SRE5,P27635,P62424,P62829,P46781,Q02878,P39019,O75694,P46779,P49207,P62851,Q8NFH4,Q14974,P62906,P39023 Rrna processing 0.5009039290110113 6.427195364850753 1.2997972835867952e-10 1.9366977800302518e-07 3.8733959348886497e-08 187 Q15061,P05387,Q8NI36,Q9UNX4,Q8IWA0,Q14690,P46777,Q02543,P26373,P08865,O75691,P46783,P62277,P62249,P62861,Q01780,Q969X6,Q9Y3U8,Q07020,P62241,P15880,O60832,P61247,P62753,Q9Y221,P62269,Q14692,Q15024,Q9Y6V7,Q14137,Q9Y2P8,P36578,O00425,P61513,P83731,P62917,P62701,Q9H4L4,P18077,Q99848,Q9NQT5,Q13895,Q9BVI4,Q9H0A0,Q9BVP2,Q15269,P62263,Q99714,Q92979,Q8IY81,P42766,Q5SY16,P63173,O00566,Q9NX24,P23396,Q9NRX1,Q9NYH9,P42285,Q9Y4W2,P18621,P62910,P62899,P46778,P46776,P08708,Q8TED0,P62750,Q9Y2X3,Q9Y2L1,P46782,P83881,P40429,Q12788,P61313,P62244,Q2NL82,P62847,P61353,P30050,P18124,Q9Y5J1,P78346,P60866,P62280,P61927,Q7L0Y3,Q9H0S4,Q13601,P05388,Q9NY93,P50914,P25398,P62081,P62266,Q9H8H0,P47914,O00541,P62888,Q9Y2R4,Q8IZL8,Q9H583,O00567,P32969,P62913,Q9BVJ6,P56182,Q9NW13,Q9BQ52,P84098,P35268,P27635,P62424,P62829,P46781,Q02878,P46087,Q8IY37,P78316,P19338,Q9Y3A2,P39019,Q9H0D6,Q5RKV6,Q9BV38,P46779,P49207,P62851,Q9NXF1,P22087,P62906,P39023,Q9NR30 Eukaryotic translation elongation 0.6402810371595088 6.344806471643134 2.2270522544900946e-10 3.3183073239014463e-07 5.16932150294061e-08 81 P05388,P05387,P62750,P26641,P46777,Q02543,P26373,P42766,P08865,P50914,P62277,P62249,P46783,P62081,P62266,P47914,Q9Y3U8,Q07020,P62241,P46782,P83881,P62888,P15880,P63173,P40429,P61247,Q05639,P62753,P32969,P62913,P62269,P29692,P23396,P24534,P61313,P84098,P36578,P62244,P62847,P35268,P27635,P61353,P83731,P62917,P62701,P62424,P30050,P46781,P18124,Q02878,P18077,P39019,P60866,P62280,P62829,P61927,P46779,P13639,P18621,P62910,P62899,P49207,P46778,P46776,P62851,P08708,P62906,P39023,P62263 Translation 0.4452606141052947 6.331458795283256 2.4285402933949174e-10 3.6185243978117146e-07 5.16932150294061e-08 261 Q14232,P05387,Q9Y2R9,P56192,P46777,Q02543,P62906,P26373,P08865,P05198,P41252,P13798,P62277,P62249,P62861,P46783,Q92665,P54136,Q9Y3U8,P62241,Q07020,P54577,O00303,P15880,P61247,O15371,P62753,Q13155,P60842,P62269,P29692,P23381,Q9Y3B7,P24534,Q15056,P20042,P36578,Q9Y285,P61513,P83731,P62917,P62701,P26639,P18077,P82930,Q9P015,O43324,O43776,Q9UHB9,Q5JTZ9,P60228,P13639,Q9BYD6,P11940,Q14152,P62263,Q9NR50,P82650,P26641,P82933,P49411,Q9BW92,P42766,Q7Z2W9,P82673,Q15005,O60841,P04843,Q6PI48,P63173,P49406,P49588,P07814,Q12904,P56537,P23396,O75821,Q9BZE1,P43897,P49770,P49589,O15372,P62857,Q9Y5M8,Q9Y262,Q04637,P82675,O76094,P04844,Q92552,Q9Y3D9,Q9NYK5,P18621,P62910,P62899,P46778,P46776,P08708,P67812,P62750,P51398,P39656,P09001,Q7L2H7,P43307,O75616,P26640,Q9NP92,P55010,Q9NSD9,P46782,P83881,P40429,Q9H2W6,P23588,Q9NSE4,O75822,P49458,Q13144,P61313,Q8TAE8,Q9Y399,Q9BRJ2,P62244,P62847,P61011,P61353,P30050,P18124,Q6P1L8,Q15046,P49591,P60866,P62280,Q5JPH6,P61927,Q9UBQ5,Q15181,Q9H2U2,P52815,P05388,P60468,P55884,P50914,P25398,P62081,P62266,P47914,Q9P2J5,Q96RP9,P62888,P15170,Q96EY7,Q05639,P32969,P62913,Q13347,P41250,Q7Z7H8,P47897,P84098,P35268,P27635,P62424,Q15031,P62829,P46781,Q02878,P61619,Q9BYD2,P39019,P82663,P62495,P37108,P14868,Q9H9J2,P08240,P46779,P49207,P62851,Q9NP81,Q9Y2Z4,P39023 Srp dependent cotranslational protein targeting to membrane 0.5949202345405578 6.274866056746988 3.4993541019842166e-10 5.214036268459588e-07 6.517547033570603e-08 98 P05387,P46777,Q02543,P26373,P08865,P62277,P62249,P46783,Q9Y3U8,Q07020,P62241,P15880,P61247,P62753,P62269,P36578,P83731,P62917,P62701,P18077,Q9UHB9,P62263,P42766,Q15005,P04843,P63173,P23396,Q9Y5M8,O76094,P04844,P18621,P62910,P62899,P46778,P46776,P08708,P62750,P39656,P43307,P46782,P83881,P40429,P49458,P61313,P62244,P62847,P61011,P61353,P30050,P18124,P60866,P62280,P61927,P05388,P60468,P50914,P62081,P62266,P47914,P62888,P32969,P62913,P84098,P35268,P27635,P62424,P62829,P46781,Q02878,P61619,P39019,P37108,P08240,P46779,P49207,P62851,P62906,P39023 Selenoamino acid metabolism 0.5911502277635065 6.21557073042207 5.113843141919415e-10 7.619623395373699e-07 8.050693798992495e-08 97 P05388,P05387,P62750,P56192,P46777,Q02543,P26373,P50914,P08865,P23526,P41252,P00390,P62277,P62249,P46783,P62081,P62266,P47914,Q9P2J5,P54136,Q07020,P62241,P62888,P15880,P63173,P40429,P61247,P07814,P62753,P32969,Q13155,Q12904,P62269,P62913,P23396,P61313,P47897,P84098,P36578,P62244,P62847,P35268,P27635,P61353,P83731,P62917,P62701,P62424,P30050,P46781,P18124,Q02878,P18077,Q15046,P39019,P49591,P14868,P62280,P62829,P46779,P49207,P18621,P62910,P62899,P62851,P46778,P46776,P08708,P62906,P39023,P62263 Metabolism of amino acids and derivatives 0.4540694649593095 6.206924609618644 5.403150190666103e-10 8.050690560484786e-07 8.050693798992495e-08 229 P08559,P05387,P62191,P56192,P46777,P31937,Q02543,P25788,P26373,P24752,P08865,P35998,P41252,P23526,P62277,P62249,P62861,P46783,O14818,P54136,Q9Y3U8,P62241,Q07020,P15880,P28072,P61247,Q9UBQ7,P62753,Q13155,P62269,Q99707,O94925,P36578,P61513,P83731,Q99436,P62701,P62917,P18077,P17174,Q15008,P25786,O43324,O00487,O75746,O43252,P60900,Q13200,P61289,P62263,P36957,O43242,P28074,Q99714,Q96C36,P62333,P42766,O00231,Q9UJS0,Q9UDR5,Q99460,Q9UL46,P48556,P49720,P63173,P07814,P34896,P00367,Q12904,P08195,P23396,P04181,O75832,O75600,P54886,P62857,Q6NVY1,Q02252,Q9UNM6,P18621,P62910,P62899,P46778,P46776,Q02218,P20618,Q13126,P08708,Q9UBX3,Q06323,P17980,P62750,P49721,P28070,P46782,P83881,P08243,O43175,P40429,P12532,P12277,P11177,P61313,P49189,P25789,P62244,P62847,P61353,P30050,P25787,P18124,Q15046,P49591,P60866,P26440,P62280,P28066,P61927,Q9Y617,P49419,O00232,P05388,P51665,Q96RQ3,P25325,P50914,P00390,P25398,P62081,P62266,P30084,P47914,Q9P2J5,P62888,P32969,P62913,P47897,P84098,P35268,P27635,P09622,P62424,P62829,P43686,Q02878,P46781,P19623,Q9HCC0,P39019,P10515,Q92947,P14868,P00505,P46779,P49207,P62851,P62195,P32322,P62906,P39023 Response of eif2ak4 gcn2 to amino acid deficiency 0.6001338819802865 6.013604006718923 1.814434249882329e-09 2.7035033817954837e-06 2.457733667104246e-07 83 P05388,P05387,P62750,P46777,Q02543,P26373,P42766,P08865,P05198,P50914,P62277,P62249,P46783,P62081,P62266,P47914,Q9Y3U8,Q07020,P62241,P46782,P83881,P08243,P62888,P15880,P63173,P40429,P61247,P62753,P32969,P62913,P62269,P23396,P61313,P20042,P84098,P36578,P62244,P62847,P35268,P27635,P61353,P83731,P62917,P62701,P62424,P30050,P46781,P18124,Q02878,P18077,P39019,P60866,Q92616,P62280,P62829,P61927,P46779,P49207,P18621,P62910,P62899,P62851,P46778,P46776,P08708,P62906,P39023,P62263 Nonsense mediated decay nmd 0.5713823536643323 5.998863277754008 1.9870356820134494e-09 2.960678787813438e-06 2.467235973075033e-07 96 P05388,P05387,P62750,P46777,Q02543,P27635,P26373,P42766,P08865,P50914,P62277,P62249,P46783,P38919,Q92900,Q09161,P62081,P62266,P47914,Q9Y3U8,Q07020,P62241,P46782,P83881,P62888,P15170,P15880,P63173,P40429,P61247,P62753,P32969,P62913,P62269,P23396,P61313,P84098,P36578,P62244,P62847,P35268,P62424,P61353,P83731,P62917,P62701,P63151,P30050,P46781,P18124,Q02878,P18077,Q04637,P46776,P39019,P62495,P60866,P62280,P62829,P61927,P46779,P49207,P18621,P62910,P62899,P62851,P46778,P30153,P11940,P08708,P62906,P39023,P62263 Signaling by robo receptors 0.48633101324110595 5.9281240783754345 3.06414937374348e-09 4.565572153106334e-06 3.5119865910521433e-07 162 P05387,P62191,P46777,Q02543,P25788,P26373,P08865,P35998,P62277,P62249,P46783,P38919,O14818,Q01518,P60953,Q9Y3U8,Q07020,P62241,P15880,P61247,P62753,P62269,P36578,P83731,Q99436,P62701,P62917,P18077,Q15008,P25786,O00487,P60900,P11940,Q13200,P61289,P62263,O43242,P28074,P62333,Q13617,P42766,O00231,Q99460,Q09161,Q9UL46,P48556,P49720,P63173,P23396,O75832,Q04637,Q9UNM6,P18621,P62910,P62899,P46778,P46776,P20618,P08708,Q06323,P17980,P62750,P49721,P28070,P46782,P83881,P40429,Q13177,Q15370,P61313,P25789,P62244,P62847,P61353,P30050,P25787,P18124,P60866,P62280,P28066,P61927,O00232,P13861,P05388,P51665,P50914,P25398,P62081,P62266,P47914,P07737,P62888,P15170,P32969,P62913,P84098,P35268,P27635,P62424,P62829,P43686,P46781,Q02878,P39019,P62495,P46779,P49207,P62851,P62195,P62906,P39023 Processing of capped intron containing pre mrna 0.4170724609634343 5.63038240572381 1.7981050240399505e-08 2.679140620442386e-05 1.913697489977519e-06 220 O43290,O94906,P52272,Q9BY77,Q9BUQ8,P30876,Q13838,P37198,Q99567,Q9Y3C6,P24928,Q7RTV0,Q9UKF6,P38919,Q12874,P49792,Q6UN15,P49790,Q96FV9,Q86V81,O75937,Q96DI7,Q15366,P57740,Q15029,P35658,Q92621,P62304,P62995,Q15365,Q08170,Q9NRG9,Q10570,O15042,Q9NW64,Q9HCS7,Q7Z3B4,Q13151,Q9BW27,P52948,O75152,Q86U42,Q07955,O95400,Q9Y333,P26599,O75494,P51991,P12270,P82979,O43143,Q9Y3B4,Q8NFH3,P52597,Q8WWY3,Q9BZJ0,P19388,P07910,P84103,Q13242,O43395,Q8IWZ8,O75533,Q6P2Q9,P41223,Q8N1F7,P22626,Q12769,P08621,Q9BZI7,Q9UBU9,Q8WYA6,Q8TEM1,Q09161,Q53GS9,Q05519,Q00839,P62314,O75643,P33240,Q96I25,P09651,Q9BXP5,O75400,Q7L014,Q15428,Q8IWX8,Q13435,Q16629,Q12996,Q92620,P42285,P35637,P14866,Q8WUA2,Q8N684,Q9UHX1,Q92797,Q8WUM0,O43809,Q13573,P78406,Q8NI27,Q86W42,P55795,P31943,P62318,P09012,Q13247,Q14103,Q9BVL2,Q9BTX1,P38159,Q8IYB3,Q15393,P62316,P26368,O43390,P61978,Q9UMS4,Q13243,Q96EE3,O60231,P51003,Q96J01,P09234,Q15637,Q9UQ35,P11142,O00148,O43447,P17844,Q05048,O75934,O60306,Q15427,Q9BUJ2,Q86XP3,Q15717,Q9Y2W2,Q15459,P62487,Q8IX12,P67809,Q08211,Q5SRE5,P08579,Q99459,P62312,Q9Y5S9,P09661,P55769,O75940,P06730,O43660,O75694,O43172,P52756,Q8NFH4,Q9P2I0,Q9UKX7 Auf1 hnrnp d0 binds and destabilizes mrna 0.6836653852571003 5.6097628145568645 2.0260409874723148e-08 3.0187555367218638e-05 1.916723827662987e-06 43 P11142,O43242,P17980,P28074,P62191,P51665,P62333,P25788,P49721,P35998,O00231,Q99460,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,Q14103,P43686,Q99436,P25787,Q04637,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,P11940,Q13200,P61289,O00232 Host interactions of hiv factors 0.5150915360693391 5.6070344603902775 2.05822692893408e-08 3.06671113127398e-05 1.916723827662987e-06 106 P52294,P06748,P62191,P37198,P46060,Q99567,P25788,Q93034,P35998,O14818,P49792,P49790,P43487,O75475,P57740,P62826,P35658,Q92621,Q9NRG9,Q99436,Q7Z3B4,Q9BW27,P52948,Q15008,P25786,O00487,O14980,P12270,P60900,Q13200,P61289,O43242,P28074,P62333,Q8N1F7,Q12769,O00231,Q9UI12,Q99460,P63208,Q8TEM1,P12236,Q9UL46,P48556,P49720,Q10567,Q96CW1,P05141,O75832,P12235,P63010,Q9UNM6,P20618,Q06323,P17980,P49721,Q8WUM0,P28070,P78406,Q13177,Q15370,P25789,P25787,Q9BTX1,O94973,P28066,P18754,O00232,O75531,P51665,P04439,Q5SRE5,O43747,P43686,Q9BXS5,O75694,Q8NFH4,P62195,Q14974,Q9UKX7 Degradation of axin 0.6903441897688597 5.500340739271608 3.790580005863534e-08 5.6478048214291436e-05 3.216797002911811e-06 38 O43242,P17980,P28074,P62191,P51665,P62333,P25788,P49721,P35998,O00231,Q99460,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Cross presentation of soluble exogenous antigens endosomes 0.6856494794652618 5.495952844509319 3.8860634933505094e-08 5.790067086892348e-05 3.216797002911811e-06 39 O43242,P17980,P28074,P62191,P51665,P62333,P25788,P49721,P35998,O00231,Q99460,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Scf skp2 mediated degradation of p27 p21 0.6662746303816821 5.475371117316507 4.365956313335434e-08 6.505063460598375e-05 3.4238288984309455e-06 43 O43242,P17980,P28074,P62191,P51665,P62333,P25788,Q13616,P49721,P35998,O00231,Q99460,P63208,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P11802,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Stabilization of p53 0.6692696977962256 5.466013482301559 4.6026934518418116e-08 6.857778244856627e-05 3.4290066216966498e-06 42 O43242,P17980,P28074,P62191,P51665,P62333,P25788,P49721,P35998,O00231,Q99460,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P04637,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 G1 s dna damage checkpoints 0.6337312107131239 5.283664267471123 1.2662521713254742e-07 0.00018865378810999672 8.610590333455295e-06 45 O43242,P17980,P28074,P62191,P51665,P62333,P25788,P49721,P35998,O00231,Q99460,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P04637,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Negative regulation of notch4 signaling 0.6417811723177879 5.28292675222222 1.2713623311042046e-07 0.00018941505808019825 8.610590333455295e-06 43 O43242,P17980,P28074,P62191,P51665,P62333,P25788,Q13616,P49721,P35998,O00231,Q99460,P63208,O14818,Q9UL46,P48556,P28070,P49720,O75832,P63104,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Mrna splicing 0.4257948466047537 5.253006940748148 1.4963589517200594e-07 0.0002229326473125914 9.638462485598825e-06 170 O43290,O94906,P52272,Q9BUQ8,P30876,Q9Y3C6,P24928,Q7RTV0,Q9UKF6,P38919,Q12874,Q6UN15,Q86V81,O75937,Q96DI7,Q15366,Q15029,P62304,P62995,Q15365,Q08170,Q10570,O15042,Q9NW64,Q9HCS7,O95400,Q13151,Q86U42,Q07955,Q9Y333,P26599,O75494,P51991,O43143,Q9Y3B4,P52597,Q8WWY3,Q9BZJ0,P19388,P07910,P84103,Q13242,O43395,Q8IWZ8,O75533,Q6P2Q9,P41223,P22626,P08621,Q9BZI7,Q8WYA6,Q09161,Q53GS9,Q05519,Q00839,P62314,O75643,P33240,Q96I25,P09651,Q9BXP5,O75400,Q7L014,Q15428,Q8IWX8,Q13435,Q16629,Q12996,Q92620,P42285,P35637,P14866,Q8WUA2,Q8N684,Q9UHX1,Q92797,O43809,Q13573,P55795,P31943,P62318,P09012,Q13247,Q14103,P38159,Q8IYB3,Q15393,P62316,P26368,O43390,P61978,Q9UMS4,Q13243,O60231,P51003,Q15637,P09234,Q9UQ35,P11142,O43447,P17844,Q05048,O75934,O60306,Q15427,Q9BUJ2,Q86XP3,Q15717,Q9Y2W2,Q15459,P62487,Q8IX12,P67809,Q08211,P08579,Q99459,P62312,Q9Y5S9,P09661,P55769,O75940,O43660,O43172,P52756,Q9P2I0 Metabolism of polyamines 0.6404578552001099 5.240677961581973 1.599877104046918e-07 0.00023835329691187243 9.638462485598825e-06 42 O43242,P17980,P28074,P62191,P51665,P62333,P25788,P49721,P35998,O00231,Q99460,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,P19623,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Asymmetric localization of pcp proteins 0.6441664948320972 5.23869143315147 1.617191692204568e-07 0.00024093255271377938 9.638462485598825e-06 41 O43242,P17980,P28074,P62191,P51665,P62333,P25788,P49721,P35998,O00231,Q99460,O14818,Q9UL46,P48556,P28070,P49720,Q14160,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Degradation of dvl 0.6420611582971351 5.222135177141432 1.7687177598356042e-07 0.0002635042461794549 9.777219960013279e-06 41 O43242,P17980,P28074,P62191,P51665,P62333,P25788,P49721,O00231,P35998,Q99460,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13618,Q13200,P61289,O00232 Activation of the mrna upon binding of the cap binding complex and eifs and subsequent binding to 43s 0.5854730981084456 5.2218221350366685 1.7717109994554934e-07 0.0002639501213413482 9.777219960013279e-06 54 P55884,P08865,Q7L2H7,P05198,P62277,P62249,P25398,P62861,P62081,P62266,P46783,P46782,P62241,O00303,P15880,P23588,P61247,O75822,O15371,P62753,P60842,Q13347,P62269,P56537,P23396,O75821,Q15056,P20042,P62244,P62847,O15372,P46781,P62701,Q9Y262,Q04637,P39019,P60866,P62280,P60228,P62851,Q9UBQ5,P11940,P08708,Q14152,P62263 Regulation of runx3 expression and activity 0.640211260635365 5.207564346847383 1.913354967873651e-07 0.0002850492832196138 9.905552441637425e-06 41 O43242,P17980,P28074,P62191,P51665,P62333,P25788,P49721,P35998,O00231,Q99460,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Cellular response to starvation 0.4783022948480097 5.206155957308376 1.9279263141341966e-07 0.0002872197929938617 9.905552441637425e-06 106 P05388,P05387,P21283,P62750,P46777,Q02543,P26373,P42766,P08865,P05198,Q9UI12,P50914,P62277,P62249,P46783,P62081,P62266,P47914,Q9Y3U8,Q07020,P62241,P46782,P83881,P08243,P62888,P15880,P63173,P40429,P61247,P62753,P32969,P38606,P62269,P62913,P23396,Q6IAA8,P21281,P61313,P20042,P84098,P36578,P62244,P62847,P35268,P62424,P61353,P83731,P62917,P62701,P27635,P30050,P46781,P18124,Q02878,P18077,P39019,P42345,P60866,Q92616,P62280,P62829,P61927,P46779,P49207,P18621,P62910,P62899,P62851,P46778,P46776,P08708,P62906,P39023,P62263 Cytosolic trna aminoacylation 0.7643730084569365 5.131615541441036 2.8726579832997276e-07 0.00042793451088833466 1.3957880578044907e-05 23 P56192,P41252,P26640,Q9P2J5,Q9NSD9,P54136,P54577,P49588,P07814,Q13155,Q12904,P41250,P23381,P47897,P49589,P26639,Q15046,P49591,O43776,P14868,Q15181 Rrna modification in the nucleus and cytosol 0.5568919564296244 5.129573832309437 2.903988576630216e-07 0.0004326007620418224 1.3957880578044907e-05 60 Q8TED0,Q15061,Q8NI36,Q9UNX4,Q92979,Q8IWA0,Q14690,Q9Y2X3,O75691,P62081,Q9H8H0,Q68CQ4,Q969X6,Q9Y2R4,Q9H583,P15880,O00567,O60832,P62753,O00566,Q9NX24,Q9BVJ6,Q14692,Q12788,Q9H6R4,Q9Y6V7,Q9Y2P8,Q9NRX1,O00425,P46781,Q9NYH9,P46087,O15213,Q9Y5J1,Q8IY37,Q9NY12,P78316,Q9Y3A2,Q9NXG2,Q9BVI4,P55769,Q9H0A0,P22087,Q9H0S4,Q15269,Q13601,P62263 Regulation of mrna stability by proteins that bind au rich elements 0.518555677904086 4.992104555153194 5.972490708661127e-07 0.0008895055365338103 2.762888893298091e-05 71 P11142,P17980,P28074,P62191,O43242,P51665,P62333,Q9Y2L1,P25788,Q92973,P49721,O00231,P35998,Q99460,P31946,O14818,P48556,P28070,P49720,Q15717,Q92945,P35658,P63104,O75832,P25789,Q14103,P43686,Q99436,P25787,Q04637,Q15008,P25786,O00487,O14980,P28066,Q5RKV6,Q9UNM6,P62195,P60900,P20618,P11940,Q13200,P61289,O00232 Defective cftr causes cystic fibrosis 0.5936383041832647 4.9874182488068755 6.119149897898524e-07 0.0009113380927140224 2.762888893298091e-05 46 O43242,P17980,P28074,P62191,P51665,P62333,P25788,P49721,P35998,O00231,Q99460,P55072,O14818,Q9UL46,P48556,P28070,P49720,Q9BUN8,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1 0.5458558322349706 4.936082831301075 7.970726541017825e-07 0.0011869337641647205 3.493053690038665e-05 55 Q06323,P17980,P28074,P62191,P53350,P51665,O43242,P62333,P25788,P49721,P35998,O00231,Q99460,O14818,Q9UL46,P48556,P28070,P49720,P30260,O75832,Q9UJX4,P25789,P43686,Q99436,P25787,Q9UJX3,Q15008,P25786,P20618,O00487,P28066,Q9UNM6,P62195,P60900,Q9UJX2,Q13200,P61289,O00232 Hedgehog ligand biogenesis 0.5799077426144005 4.871954312122943 1.1049972539201036e-06 0.0016450921679950214 4.704131166692698e-05 46 O43242,P17980,P28074,P62191,P51665,P62333,P25788,P49721,P35998,O00231,Q99460,P55072,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P07237,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Tnfr2 non canonical nf kb pathway 0.5747773650270039 4.860382316363649 1.1715927357158762e-06 0.001744151395858564 4.849092156161515e-05 47 O43242,P17980,P28074,P62191,P51665,P62333,P61081,P25788,Q13616,P49721,P35998,O00231,Q99460,P63208,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Dectin 1 mediated noncanonical nf kb signaling 0.5708358781493982 4.826695043501563 1.388174374339357e-06 0.0020662436269624908 5.4790665994153336e-05 47 O43242,P17980,P28074,P62191,P51665,P62333,P61081,P25788,Q13616,P49721,P35998,O00231,Q99460,P63208,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 The role of gtse1 in g2 m progression after g2 checkpoint 0.5337910716640751 4.825382846670698 1.3973458441451925e-06 0.0020798808065552784 5.4790665994153336e-05 55 Q06323,P17980,P28074,P62191,P53350,P51665,O43242,P62333,P25788,P06493,P49721,P35998,O00231,Q99460,O14818,Q9UL46,P48556,P28070,P49720,Q9BUF5,P28072,O75832,P25789,P08238,P43686,Q99436,P07900,P25787,Q15008,P25786,O00487,P04637,P28066,Q9UNM6,Q15691,P62195,P60900,P20618,Q13200,P61289,O00232 Regulation of hmox1 expression and activity 0.5504743254956079 4.782641682448687 1.7300636181438733e-06 0.0025744773552598076 6.609730233425285e-05 52 Q06323,P17980,P28074,P62191,O43242,P51665,P62333,P09601,P25788,Q13616,P49721,O00231,P35998,Q99460,P63208,O14818,Q9UL46,P48556,P28070,P49720,P28072,Q8TCT9,O75832,P25789,P43686,Q99436,P25787,P67870,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13618,Q13200,P61289,O00232 Regulation of ras by gaps 0.5739101116419975 4.759060963607555 1.944956895982841e-06 0.0028937934777490864 7.244964437539808e-05 44 O43242,P17980,P28074,P62191,P51665,P62333,P25788,P49721,O00231,P35998,Q99460,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13618,Q13200,P61289,O00232 Disorders of transmembrane transporters 0.4596376943102779 4.739253427898774 2.1450708462822377e-06 0.0031910567101612413 7.795501368200058e-05 91 Q06323,O43242,P28074,P62191,P17980,P51665,P62333,Q99567,P37198,Q8N1F7,Q12769,P25788,P49721,P35998,O00231,Q99460,Q8TEM1,P55072,O14818,P49792,Q8WUM0,P49790,Q9UL46,P48556,P28070,P49720,P78406,Q9BUN8,P57740,P08195,P35658,P19367,Q92621,O75832,P25789,O94905,Q5SRE5,Q9NRG9,P43686,Q99436,P53985,P25787,Q7Z3B4,Q9BW27,Q9BTX1,P52948,P35613,Q15008,P25786,Q6P1M0,O00487,P28066,P12270,O75694,Q9UNM6,Q8NFH4,P62195,P60900,P20618,Q13200,P61289,Q9UKX7,O00232 Apc c mediated degradation of cell cycle proteins 0.5037947161359415 4.72460066993092 2.3056797655574e-06 0.003429572347131793 8.179673454004801e-05 65 Q06323,P17980,P28074,P62191,P53350,P51665,O43242,P62333,P25788,P06493,Q13616,P49721,P35998,O00231,Q99460,P63208,O14818,Q9UL46,P48556,P28070,P49720,P28072,P30260,O75832,Q9UJX4,P25789,P43686,Q99436,P25787,Q9UJX3,Q15008,P25786,P20618,O00487,P28066,Q9UNM6,P62195,P60900,Q9UJX2,Q13200,P61289,O43684,O00232 Orc1 removal from chromatin 0.5116029628816916 4.6879881136597055 2.7590403932631347e-06 0.004102537363333179 9.560395781310605e-05 59 P25205,O43242,P17980,P28074,P62191,P51665,P62333,P25788,Q13616,P49721,P35998,O00231,Q99460,P63208,O14818,Q9UL46,P48556,P28070,P49720,P33991,O75832,P25789,Q14566,P43686,Q99436,P25787,Q15008,P33992,P25786,O00487,P28066,P33993,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,P49736,O00232 Pcp ce pathway 0.512621036973218 4.645107932593078 3.398987049818558e-06 0.005051696357318588 0.00011510206145979867 56 Q06323,P17980,P28074,P62191,O43242,P51665,P62333,P25788,P49721,P35998,O00231,Q99460,O14818,Q9UL46,P07737,P48556,P28070,Q00610,P49720,Q96CW1,Q14160,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,P63010,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Regulation of runx2 expression and activity 0.5439406708303973 4.618878946845184 3.858188490024617e-06 0.005732219713621536 0.0001277489077808482 48 O43242,P17980,P28074,P62191,P51665,P62333,P25788,Q13616,P49721,P35998,O00231,Q99460,P63208,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Glucose metabolism 0.4809961500462515 4.557255906164385 5.1826265319299125e-06 0.007692394468769251 0.0001678720333168926 68 P60174,P06744,P30154,Q01813,P11498,Q9UKX7,P52789,P37198,Q8N1F7,Q12769,Q99567,A6NDG6,Q14738,Q9UJS0,Q8TEM1,P49792,P46926,Q9BRR6,Q8WUM0,P49790,P78406,P04406,P00558,P18669,P14618,P04075,P57740,P35658,P40925,P19367,Q92621,P17858,Q5SRE5,Q9NRG9,P40926,Q7Z3B4,Q9BTX1,Q9BVL2,P52948,P17174,Q9BW27,P53007,P00505,P06733,P12270,O75694,O75746,Q8NFH4,P30153,P08237,P09972,Q9UBX3,Q02978 Degradation of gli1 by the proteasome 0.5339450530820343 4.5056216932962005 6.617889885207617e-06 0.009812231372587752 0.0002098011899778902 47 O43242,P17980,P28074,P62191,P51665,P62333,P25788,Q13616,P49721,P35998,O00231,Q99460,P63208,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Trna aminoacylation 0.5508471176334746 4.476076905415015 7.602710836440707e-06 0.011264161080769403 0.00023600081554787797 41 P56192,Q9BW92,P41252,P26640,Q9P2J5,Q9NSD9,P54136,P54577,Q6PI48,Q9NSE4,P49588,P07814,Q13155,Q12904,P41250,P23381,P47897,Q9Y285,P49589,P26639,Q15046,P49591,O43776,P14868,Q15181,Q9NP81,Q9Y2Z4 Cellular responses to stimuli 0.28492919918420634 4.457500909542242 8.292068545578957e-06 0.01227922083540935 0.0002521465741411048 447 P05387,P62191,O95757,P46777,Q99567,Q02543,P34932,P25788,P26373,P35611,P08865,P35998,P39023,P25685,P62277,P62249,P05198,P30044,P46783,O14818,P49792,P62861,P49959,P49790,Q92598,Q07020,P62241,P16403,Q9Y3U8,P30041,Q9Y490,P15880,P20674,P61247,P28072,P16402,P62753,P57740,Q15022,Q9Y6G9,P62269,P38606,P30048,P27797,P30260,P35658,Q92621,P31948,Q15418,Q15024,P20042,P36578,P08238,Q9NRG9,P61513,P83731,P62917,P62701,Q99436,P07900,Q7Z3B4,Q9BW27,P18077,P52948,Q9NQT5,P11802,Q15008,P38646,P07237,P25786,Q92616,O00487,O14980,P12270,P14625,P61163,P37198,P60900,Q13200,P61289,P62263,Q9HCE1,O43242,Q96HE7,P28074,Q92878,Q8N163,P62333,Q8N1F7,Q12769,Q13617,Q15084,P20700,Q13616,P62258,Q9UI12,O00231,Q99460,P42766,Q8TEM1,P63208,Q9HCU5,Q9UL46,P48556,P49720,P63173,Q02790,P02545,P23396,O94979,O75832,Q14203,Q9Y4L1,P13073,Q99615,Q9Y5M8,Q9UJW0,Q9UJX3,P42345,P53004,P47756,Q15185,Q9UNM6,O14773,P18621,P62910,P62899,P46778,P46776,P27694,O00483,P20618,P08708,Q13561,Q06323,P17980,P21283,P62750,P09601,Q9Y2L1,P30519,P49721,P43307,P55072,Q8WUM0,P28070,P46782,P78406,P83881,P08243,Q9BUF5,P10412,P62805,P40429,O75935,P00403,Q92945,P52907,Q6IAA8,P21281,P32119,Q15370,Q8TCT9,P61313,Q9UJX4,P25789,P62244,P62847,P61353,Q86X55,P30050,P25787,P18124,Q9BTX1,Q06210,P60866,P62280,P28066,P61927,Q8N6T3,Q13618,P50454,O00232,P51812,P11142,P05388,P04179,P51665,P50914,P00390,P25398,P62081,P62266,O60884,P47914,P62888,Q13217,P32969,P62913,P07305,P84098,P62829,P62424,P35268,P43686,P46781,P31689,Q02878,P27635,Q5SRE5,P51858,P10606,P67870,Q969H8,P42704,P39019,P04637,P0DMV9,P08240,Q5RKV6,O75694,P46779,P49207,P62851,Q13451,Q8NFH4,P62195,Q9UJX2,Q14204,P62906,Q9UKX7,O95453 Fceri mediated nf kb activation 0.4917688353743563 4.429937584814176 9.426036529314175e-06 0.01394669169455442 0.0002808958885735922 55 O43242,P17980,P28074,P62191,P51665,P62333,P25788,Q13616,P49721,P35998,O00231,Q99460,P63208,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Antigen processing cross presentation 0.4770794959460152 4.423799145670462 9.698018869963576e-06 0.01434621629427218 0.00028333427678916114 63 Q06323,O43242,P17980,P28074,P62191,P51665,P60468,P62333,P25788,P49721,P35998,O75396,O00231,Q99460,O14818,Q9UL46,P48556,P28070,P49720,P30101,P10321,P04439,P27797,O75832,P25789,P43686,Q99436,P61619,P09429,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Cdt1 association with the cdc6 orc origin complex 0.5236814567458289 4.414380975703066 1.0129943022407772e-05 0.014980352740504873 0.0002890923041567407 47 O43242,P17980,P28074,P62191,P51665,P62333,P25788,P49721,P35998,O00231,Q99460,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Signaling by notch4 0.5122443762328609 4.411132236893562 1.0283149074030717e-05 0.015205186718774138 0.0002890923041567407 51 Q06323,O43242,P17980,P28074,P62191,P51665,P62333,P25788,Q13616,P49721,P35998,O00231,Q99460,P63208,O14818,Q9UL46,P48556,P28070,P49720,P63104,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Cellular response to hypoxia 0.5175869797937138 4.384147638094604 1.1644078735884023e-05 0.017200137584761053 0.000321290320675346 48 Q06323,P17980,P28074,P62191,O43242,P51665,P62333,Q13617,P25788,P49721,P35998,O00231,Q99460,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Abc family proteins mediated transport 0.4720088231901749 4.373192750828742 1.2244252620252638e-05 0.01807863292625284 0.0003317079346214167 63 O43242,P17980,P28074,P62191,P51665,P62333,P25788,P49721,O00231,P35998,Q99460,P05198,P55072,O14818,P28288,Q9UL46,P48556,P28070,P49720,O75027,Q9BUN8,O75832,P25789,P20042,Q8NE71,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 The retinoid cycle in cones daylight vision -0.9989212513484563 -4.35665445295537 1.3206551106037523e-05 0.019485545108584714 0.00035138859192852497 1 O75911 Regulation of pten stability and activity 0.5075446803938354 4.342591280797941 1.4081194976256484e-05 0.020762555665641537 0.0003665362894239259 50 Q06323,P17980,P28074,P62191,O43242,P51665,P62333,P25788,P49721,P35998,O00231,Q99460,O14818,Q9UL46,P48556,P28070,P49720,P28072,O75832,P25789,P43686,Q99436,P25787,P67870,Q15008,P19784,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Recycling of bile acids and salts -0.995325422509909 -4.339698161588158 1.4267855561467258e-05 0.021034871356315606 0.0003665362894239259 1 O95342 Infectious disease 0.2700902757318609 4.335169253630654 1.4564801378069703e-05 0.021467924193657822 0.0003678229500563618 480 P54709,P08754,P06748,P05387,P62191,O60341,Q96SB4,Q08945,P30876,P46777,P46060,Q02543,P24928,P25788,P26373,Q99567,P08865,P35998,P39023,Q9Y3E5,P62277,P62249,P35579,P46783,O14818,P49792,P60953,P27824,P49790,Q00610,Q07020,P62241,P43487,Q9Y3U8,O75475,Q9Y5B9,P15880,Q9Y2A7,P61247,O00410,P62753,P62826,P57740,Q9Y6G9,P62269,Q15022,P27797,P35658,Q92621,P36578,P08238,Q9NRG9,P83731,P62917,P62701,Q99436,P07900,Q7Z3B4,Q9BW27,P18077,P62993,P52948,Q15008,P25786,O00487,P05023,O14980,P12270,P13639,P60900,Q13200,P61289,P62263,O43242,P28074,O00267,P62333,P10644,Q8N1F7,Q12769,P42766,Q9UI12,O00231,Q99460,P63208,Q8TEM1,Q8WUM4,Q09161,P12236,Q12849,Q9UL46,P48556,P49720,P04843,Q10567,Q96CW1,Q13724,P63173,Q02790,P51149,P05141,P05556,P23396,P14314,O75832,P12956,P12235,O94776,P63010,P19525,P04844,Q15185,Q9UNM6,P18621,P62910,P62899,Q9UQB8,P46778,P46776,O60716,P20618,Q92769,P08708,Q06323,Q99873,P17980,P62750,P39656,P07437,P09601,P49721,P55072,Q8WUM0,P09874,P28070,P46782,P78406,P83881,Q9BUF5,Q99961,O15145,P62805,P40429,Q7L576,Q13177,Q15370,Q86YP4,P61313,P25789,P62244,P62847,P61353,P30050,P25787,P18124,Q9BTX1,P60866,O00159,O94973,Q9Y2Z0,P62280,P61978,P52292,P28066,P18754,P23246,P61927,P06733,Q13618,P61158,O00232,P21964,O75531,P13861,P05388,P51665,P17844,P50914,O00422,P62081,P62266,P47914,P62888,P62487,P00558,Q14839,P32969,P62913,P39748,P46977,P84098,P62829,P62424,P35268,P43686,P46781,P27635,Q02878,O43747,P59998,Q14697,P39019,P30419,Q13263,P35222,P13010,O75694,P46779,P49207,P62851,Q9NZI8,P12268,P62195,Q14974,Q14204,P62906,Q9UKX7 Cyclin a cdk2 associated events at s phase entry 0.4916084244836607 4.304775768791202 1.6715495512631406e-05 0.024598693712974636 0.0004151014718970381 53 P17980,P28074,P62191,O43242,P51665,P62333,P25788,Q13616,P49721,P35998,O00231,P63208,Q99460,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P11802,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Interactions of rev with host cellular proteins 0.5427825330882737 4.300357808316916 1.7052255718130738e-05 0.02508800895480993 0.0004165223118035457 37 P06748,Q99567,P46060,Q12769,Q8N1F7,Q8TEM1,P49792,Q8WUM0,P49790,P78406,P43487,P57740,P62826,P35658,Q92621,Q5SRE5,Q9NRG9,Q7Z3B4,Q9BTX1,Q9BW27,P52948,O14980,P12270,O75694,P18754,Q8NFH4,Q14974,Q9UKX7 Histidine catabolism -0.9856166846458311 -4.29374584460607 1.7568357764563558e-05 0.02583743330972742 0.0004176373437682212 1 Q8N4J0 Glycolysis 0.4758925135496607 4.292397871330312 1.7675385683313394e-05 0.0259927749226554 0.0004176373437682212 56 P60174,P06744,P30154,Q01813,P52789,P37198,Q8N1F7,Q12769,Q99567,A6NDG6,Q14738,Q8TEM1,P49792,Q8WUM0,Q9BRR6,P46926,P49790,P78406,P04406,P00558,P18669,P14618,P04075,P57740,P35658,P19367,Q92621,P17858,Q5SRE5,Q9NRG9,Q7Z3B4,Q9BTX1,Q9BVL2,P52948,Q9BW27,P06733,P12270,O75694,Q8NFH4,P30153,P08237,P09972,Q9UKX7 Switching of origins to a post replicative state 0.45079646154317243 4.286897599217434 1.8118576254000374e-05 0.02663576362550462 0.0004176373437682212 70 Q06323,P25205,P17980,P28074,P62191,O43242,P51665,P62333,P25788,Q13616,P49721,P35998,O00231,Q99460,P63208,O14818,Q9UL46,P48556,P28070,P49720,P33991,P30260,O75832,P25789,Q14566,P43686,Q99436,P25787,Q9UJX3,Q15008,P33992,P25786,O00487,P28066,P33993,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,P49736,O00232 Tnfr1 mediated ceramide production 0.977346278317152 4.2856681420597456 1.8219078754988516e-05 0.02678151541508973 0.0004176373437682212 1 Degradation of beta catenin by the destruction complex 0.4674202199838527 4.2416185608696635 2.2191360999901377e-05 0.0325248070564822 0.0005009867862099173 58 O43242,P17980,P28074,P62191,P51665,P62333,P25788,Q14738,Q13616,P49721,P35998,O00231,Q99460,P63208,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P30153,P35222,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Nuclear envelope breakdown 0.5020725642166728 4.219451063989823 2.4489787087356163e-05 0.035832485829060345 0.0005446236232860025 47 Q8TD19,O75531,P53350,P37198,Q8N1F7,Q12769,Q99567,P06493,P20700,Q8TEM1,P49792,Q8WUM0,Q99986,P49790,P78406,Q9Y2U8,P02545,P50402,P57740,P42167,P35658,Q92621,Q5SRE5,P14635,Q9NRG9,Q7Z3B4,Q9BTX1,Q9BVL2,P52948,Q9BW27,P12270,O75694,P42166,Q8NFH4,Q9UKX7 Adenylate cyclase activating pathway -0.9660194174757479 -4.20022119684327 2.6665434099903962e-05 0.03895306028402186 0.0005842867177773294 1 O60266 Gene and protein expression by jak stat signaling after interleukin 12 stimulation 0.6047838035622767 4.188151773921201 2.8123542110014554e-05 0.041038803137796176 0.0006073054745496112 26 P17987,P26038,P05388,P04179,P07355,P22626,P20700,P37837,P60953,Q9UL46,P23528,P78417,Q13177,P14174,P52907,O14979,P38646,P52597,P09661,Q13126 Interactions of vpr with host cellular proteins 0.527834223459831 4.173412141198905 3.0007140857879477e-05 0.04372649209251604 0.0006387234268320273 37 O75531,P52294,P37198,Q8N1F7,Q12769,Q99567,Q8TEM1,P49792,Q8WUM0,P12236,P49790,P78406,O75475,P17096,P05141,P57740,P35658,Q92621,Q5SRE5,Q9NRG9,P12235,Q7Z3B4,Q9BTX1,Q9BVL2,P52948,Q9BW27,P12270,O75694,Q8NFH4,Q9UKX7 Runx1 regulates transcription of genes involved in differentiation of hscs 0.4912798841824298 4.167997876848897 3.0728679627278765e-05 0.04475405356753594 0.0006448694738682655 49 P17980,P28074,P62191,O43242,P51665,P62333,P25788,P49721,P35998,O00231,Q99460,O14818,Q9UL46,P48556,P28070,P49720,P62805,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Flt3 signaling through src family kinases -0.9570298453793795 -4.156969647326634 3.2249681781948425e-05 0.04691653772793527 0.0006673892479875646 1 P06241 Nervous system development 0.2979302640175658 4.15015649211882 3.322480406753314e-05 0.048300343155614774 0.0006781501104195325 290 Q96P70,P05387,P62191,P60660,P46777,Q02543,P25788,P26373,P35579,P08865,P35998,P62277,P62249,P46783,P38919,O14818,Q01518,P60953,Q00610,Q9Y3U8,Q07020,P62241,Q9Y490,P15880,P61247,P62753,P62269,P50570,P35241,P36578,P08238,P83731,Q99436,P62701,P07900,P62917,P62993,P18077,Q15008,P25786,O00487,P60900,P11940,Q13200,P61289,P62263,P26038,O43242,P28074,P15311,P62333,Q13617,P42766,O00231,Q99460,Q09161,Q9UL46,P48556,P49720,Q96CW1,P63173,P05556,P23396,O75832,P35580,Q04637,Q01082,P63010,Q9UNM6,P18621,P62910,P62899,P46778,P46776,P20618,Q92769,P08708,Q06323,P17980,P62750,P49721,P28070,P46782,Q9BUF5,P83881,O15145,P40429,Q13177,Q13813,Q15370,P61313,Q16555,P25789,P62244,P46939,P62847,P61353,P30050,P25787,P18124,O95239,Q16850,P60866,O94973,P62280,P28066,P61927,P61158,O00232,P51812,P11142,P05388,P13861,P51665,P61160,P50914,P25398,P62081,P62266,P47914,P07737,P23528,P62888,P15170,P32969,P62913,P51532,P84098,P35268,P27635,P62424,P62829,P43686,P46781,Q02878,P59998,P39019,P62495,P46779,P49207,P62851,P62195,P62906,P39023 Diseases associated with surfactant metabolism -0.9548723480762511 -4.146556013865944 3.375136383532151e-05 0.04904675416380976 0.0006795882718193318 1 Q99758 Synthesis of dna 0.39184084270308006 4.1407549793412155 3.461645743496611e-05 0.05027177506481424 0.0006877136210413467 101 Q06323,P25205,O43242,P28074,P62191,P17980,P51665,P62333,Q9BRT9,P25788,Q07864,Q13616,P49721,P35998,O00231,Q99460,P63208,P35249,O14818,P49643,Q9UL46,P48556,P28070,P49720,P33991,P28340,P30260,P39748,P35250,P12004,O75832,P25789,Q14566,P43686,P40937,Q99436,P25787,Q9UJX3,Q15008,Q9Y2S7,P33992,P25786,O00487,P33993,P28066,Q9UNM6,P62195,P27694,P60900,P20618,Q13200,P61289,P49736,O00232 Transport of fatty acids 0.935634663790004 4.08578576117633 4.392789799823049e-05 0.06335787399124354 0.0008612180002284859 1 Uch proteinases 0.4509345720805201 4.076950637235705 4.563017504954914e-05 0.06573066215950599 0.0008829735171925937 58 Q06323,Q9Y5K5,P17980,P28074,P62191,O43242,P51665,O96019,P62333,P25788,P49721,P35998,O00231,Q99460,O14818,Q9UL46,P48556,P28070,P49720,Q9Y265,P51610,O75832,P25789,P43686,Q99436,O15294,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Abc transporter disorders 0.4714304186406577 4.054566491321949 5.0227362585530955e-05 0.07210866577482075 0.000959471413492854 52 P17980,P28074,P62191,O43242,P51665,P62333,P25788,P49721,P35998,O00231,Q99460,P55072,O14818,Q9UL46,P48556,P28070,P49720,Q9BUN8,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Cgmp effects -0.9336569579288216 -4.043458937188616 5.266838387507633e-05 0.07547756256635763 0.0009809486496733153 1 Q13976 Nitric oxide stimulates guanylate cyclase -0.9336569579288216 -4.043458937188616 5.266838387507633e-05 0.07547756256635763 0.0009809486496733153 1 Q13976 Dna replication pre initiation 0.4167328674932842 4.040518109400926 5.333324635570236e-05 0.07639303117873059 0.0009810683588888642 76 Q06323,P25205,P17980,P28074,P62191,O43242,P51665,P61289,P62333,P25788,P49721,P35998,O00231,Q99460,O14818,P49643,Q9UL46,P48556,P28070,P49720,P33991,P62805,O75832,P25789,Q14566,P43686,Q99436,P25787,Q15008,P33992,P25786,O00487,P28066,P33993,Q9UNM6,P62195,P27694,P60900,P20618,Q13200,Q14974,P49736,O00232 Hdl remodeling -0.9280834232290732 -4.016161548939355 5.9153714139892344e-05 0.08436882342028058 0.001072335570474539 1 P02656 Mitotic prophase 0.4214533969988081 4.013858638423233 5.973412909354714e-05 0.0851603827269629 0.001072335570474539 72 Q08379,O75531,Q8TD19,P30154,P53350,Q9NTJ3,P37198,Q8N1F7,Q12769,Q99567,Q01105,P06493,P20700,P62820,Q8TEM1,P49792,Q8WUM0,O60763,Q99986,O95347,P49790,P78406,P28482,P61019,P62805,Q9Y2U8,Q9H8Y8,P02545,P50402,P57740,P42167,Q8NC56,P35658,Q92621,Q5SRE5,P14635,Q9NRG9,P16104,Q7Z3B4,Q9BTX1,Q9BVL2,P52948,Q14980,Q9BW27,Q9H0U4,Q8NFH5,P12270,O75694,P42166,Q96EE3,Q8NFH4,Q8NFH3,P30153,Q9UKX7 Nuclear import of rev protein 0.5255157699974616 4.006942938646804 6.150971578455788e-05 0.08757765206613094 0.0010746811127189857 34 P06748,Q99567,Q8N1F7,Q12769,Q8TEM1,P49792,Q8WUM0,P49790,P78406,P57740,P62826,P35658,Q92621,Q5SRE5,Q9NRG9,Q7Z3B4,Q9BTX1,Q9BW27,P52948,P12270,O75694,P18754,Q8NFH4,Q14974,Q9UKX7 Synthesis of bile acids and bile salts via 27 hydroxycholesterol -0.9259259259259448 -4.005570745409294 6.186791303264272e-05 0.08806452465327248 0.0010746811127189857 1 O75881 Downstream signaling events of b cell receptor bcr 0.4453589444588657 4.004957720977576 6.202857429116193e-05 0.08828281597185479 0.0010746811127189857 57 O43242,P17980,P28074,P62191,P51665,P62333,P25788,Q13616,P49721,P35998,O00231,Q99460,P63208,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Rhobtb gtpase cycle 0.5410033325628429 3.9626138370658612 7.413363928909789e-05 0.10458073430923447 0.0012610798521735709 31 Q99832,Q13838,Q8N684,Q9NYL9,Q7Z6E9,P78371,P62995,P61201,Q16543,P08238,P12814,P40227,Q8WWQ0,P07900,P38159,Q9UM54,Q96T58,Q8IYB3,Q9BT78,Q13098,P08670,Q16643,Q13618,P07910 Phosphate bond hydrolysis by ntpdase proteins -0.9169363538295764 -3.9612966241877046 7.454385932614827e-05 0.10512791294063965 0.0012610798521735709 1 Q9NQZ7 Programmed cell death 0.34939170309548095 3.958803281754294 7.532624620365524e-05 0.10617058610899792 0.0012610798521735709 136 O43242,P28074,P62191,P17980,P51665,P62333,P49327,P25788,P35611,P20700,P62258,P35998,O00231,Q9UKV3,Q99460,Q8WUM4,Q14126,P49721,P31946,O14818,O60313,P48556,P28070,P49720,P16403,O00429,Q04917,P02545,P27348,P51572,Q13813,Q07021,Q07157,P07305,O75832,P63104,Q16543,Q15149,P25789,O00273,P43686,Q99436,O15294,P07900,P09429,P25787,Q14254,P15924,P25786,P30419,O75955,O00487,P04637,P35222,P28066,Q9UNM6,Q14974,P08670,P62195,P60900,P20618,Q13200,P61289,O00232 Sodium calcium exchangers 0.9047105357784967 3.9345043887376003 8.336854554436002e-05 0.11681828882815301 0.0013802125873455325 1 Ns1 mediated effects on host pathways 0.4967138700136727 3.927977029122145 8.566339064275397e-05 0.11983326629804962 0.0014026203522824715 38 P52294,Q99567,P37198,Q12769,Q8N1F7,O00505,Q8TEM1,P49792,Q8WUM0,P49790,P78406,P57740,P35658,Q92621,Q5SRE5,Q9NRG9,Q7Z3B4,Q9BTX1,Q9BVL2,P52948,Q9BW27,Q86U42,P19525,P52292,P12270,O75694,Q8NFH4,Q14974,Q9UKX7 Hedgehog on state 0.45624985840809656 3.908461538750978 9.288573078003459e-05 0.12925504790138054 0.0015043449876331852 52 O43242,P17980,P28074,P62191,P51665,P62333,P25788,P49721,P35998,O00231,Q99460,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,Q6P1J9,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13618,Q13200,P61289,O00232 Transport of mature transcript to cytoplasm 0.40240240981233305 3.881984295725577 0.00010360756977334518 0.14305648845368385 0.0016599492361536107 76 O00148,Q9BY77,Q13838,P37198,Q8N1F7,Q12769,Q99567,Q92797,Q9UBU9,Q9UKF6,Q8TEM1,Q13242,P38919,Q09161,P49792,Q8WUM0,Q6UN15,P49790,P78406,Q05519,Q96FV9,Q86V81,P57740,Q8NI27,Q86W42,P35658,Q92621,Q08170,Q5SRE5,Q13247,Q9NRG9,Q10570,Q7Z3B4,Q9BW27,Q9BTX1,O75152,Q9BVL2,Q8IYB3,Q07955,P52948,Q16629,P26368,Q9Y5S9,Q92620,P06730,P12270,O75694,P82979,Q13243,Q96EE3,Q8NFH4,Q8NFH3,Q9P2I0,Q96J01,P84103,Q9UKX7 Tcr signaling 0.4232196824935047 3.873249568937585 0.0001073937538573766 0.14787775829026165 0.0016857840047427978 63 Q06323,O43242,P17980,P28074,P62191,P51665,P62333,P25788,Q13616,P49721,O00231,P35998,Q99460,P63208,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P41240,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Activated ntrk2 signals through pi3k 0.8923049262855083 3.8730474921887876 0.00010748287278561364 0.14799091386368635 0.0016857840047427978 1 Transcriptional regulation by runx3 0.44016568607383827 3.8634839286902904 0.00011178125079425172 0.15343083455143258 0.0017212591580076273 54 Q06323,O43242,P17980,P28074,P62191,P51665,P62333,P25788,P49721,P35998,O00231,Q99460,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P04637,P35222,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Apoptosis 0.35109371087384017 3.862886395606865 0.00011205512639378412 0.15377626613600234 0.0017212591580076273 120 O43242,P28074,P62191,P17980,P51665,P62333,P49327,P25788,P35611,P20700,P62258,P35998,O00231,Q9UKV3,Q99460,P49721,Q14126,P31946,O14818,O60313,P48556,P28070,P49720,P16403,O00429,Q04917,P02545,P27348,P51572,Q13813,Q07021,Q07157,P07305,O75832,P63104,Q15149,P25789,O00273,P43686,Q99436,P09429,P25787,P15924,P25786,P30419,O00487,P04637,P35222,P28066,Q9UNM6,Q14974,P08670,P62195,P60900,P20618,Q13200,P61289,O00232 Mapk6 mapk4 signaling 0.42633590903853835 3.8573427111134273 0.00011462639370418692 0.1570124721758578 0.0017427890471351023 60 Q06323,Q9HCE1,P17980,P28074,P62191,O43242,P51665,P62333,P25788,P06493,P25685,P35998,O00231,Q99460,P49721,O14818,P60953,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,O14980,P28066,Q9UNM6,Q9NZI8,P62195,P60900,P20618,Q13200,P61289,O00232 Antiviral mechanism by ifn stimulated genes 0.4275817819390345 3.8545559263060265 0.00011593987931113325 0.1586608541185643 0.0017449537391271723 59 P52294,P21333,P37198,Q8N1F7,Q12769,Q99567,O00505,Q8TEM1,P38919,P49792,Q8WUM0,P49790,P78406,P61221,P57740,P60842,P35658,Q92621,Q5SRE5,Q9NRG9,P42224,Q7Z3B4,Q9BTX1,Q9BVL2,P52948,Q04637,O43432,Q9Y4X5,Q9BW27,O75369,Q14258,P19525,P52292,P06730,P19174,O75694,P12270,Q96EE3,Q8NFH4,Q8NFH3,Q6L8Q7,P78344,Q14974,Q9UKX7 Nuclear pore complex npc disassembly 0.5071861648198818 3.851574904645599 0.00011736062033884664 0.16044021196528713 0.0017486732430488298 34 Q8TD19,Q99567,P37198,Q12769,Q8N1F7,P06493,Q8TEM1,P49792,Q8WUM0,P49790,P78406,P57740,P35658,Q92621,Q5SRE5,P14635,Q9NRG9,Q7Z3B4,Q9BTX1,Q9BVL2,P52948,Q9BW27,P12270,O75694,Q8NFH4,Q9UKX7 Irs activation -0.8881697231211975 -3.8180091329092165 0.00013453294646215141 0.18165197569707842 0.001984693962659476 1 Q13322 Interleukin 1 signaling 0.4196446444658515 3.8034392036668097 0.0001427010270156348 0.19155263373972262 0.002084554218169582 61 O43242,P17980,P28074,P62191,P51665,P62333,P25788,Q13616,P49721,P35998,O00231,Q99460,P63208,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P09429,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Fibronectin matrix formation 0.8745055735346988 3.7840806705645518 0.00015427778092824695 0.20538028733660446 0.0022317853745931013 1 Export of viral ribonucleoproteins from nucleus 0.512149850576885 3.78018069902773 0.00015671458007826544 0.2082606327054956 0.002245237733813625 32 Q99567,Q8N1F7,Q12769,Q8TEM1,P49792,Q8WUM0,P49790,P78406,P57740,P62826,P35658,Q92621,Q5SRE5,Q9NRG9,Q7Z3B4,Q9BTX1,Q9BW27,P52948,O14980,P12270,O75694,Q8NFH4,Q9UKX7 Androgen biosynthesis 0.8692916217188051 3.7578407186081058 0.00017138591469567643 0.2253832579855862 0.002432047741871994 1 Dna replication 0.35006991627847384 3.742785895620183 0.00018199128764995187 0.2375296805807911 0.0025581794207399037 111 P40938,Q06323,P52294,P25205,O43242,P28074,P62191,P17980,P51665,P62333,Q9BRT9,P25788,Q07864,Q13616,P49721,P35998,O00231,Q99460,P63208,P35249,Q9UJX2,O14818,P49643,Q9UL46,P48556,P28070,P49720,P33991,P28340,P62805,P28072,P30260,P39748,P35250,P12004,O75832,Q9UJX4,P25789,Q14566,P43686,P40937,Q99436,P25787,Q9UJX3,Q15008,Q9Y2S7,P33992,P25786,O00487,P35251,P33993,P28066,Q9UNM6,Q14974,P62195,P27694,P60900,P20618,Q13200,P61289,P49736,O00232 Interleukin 12 family signaling 0.49562303787234674 3.6956791107739924 0.00021929981291268774 0.27876665647275145 0.003053801133083236 33 P17987,P26038,P05388,P04179,P07355,P22626,P20700,P37837,P60953,P27824,Q9UL46,P23528,P11233,P78417,Q13177,P14174,P52907,P40763,P42224,O14979,P38646,P07237,P51809,P52597,P09661,Q13126 Sumoylation of dna replication proteins 0.46030778634686614 3.673347500138991 0.00023939357173685671 0.30004492468409916 0.0033027446471103517 41 Q99567,P46060,Q12769,Q8N1F7,Q8TEM1,P49792,Q8WUM0,P49790,P78406,P57740,P35658,P12004,Q92621,Q5SRE5,Q9NRG9,Q02880,P11387,Q7Z3B4,Q9BTX1,Q9BW27,P52948,P11388,P12270,O75694,Q8NFH4,Q9UKX7 Slc transporter disorders 0.4650369239741319 3.667934109666669 0.0002445181734058721 0.3053704718375502 0.0033424961318784486 39 Q99567,Q8N1F7,Q12769,Q8TEM1,P49792,Q8WUM0,P49790,P78406,P57740,P08195,P35658,P19367,Q92621,Q5SRE5,Q9NRG9,P53985,Q7Z3B4,Q9BTX1,Q9BW27,P35613,P52948,Q6P1M0,P12270,O75694,Q8NFH4,Q9UKX7 Negative regulation of activity of tfap2 ap 2 family transcription factors -0.8577849694354722 -3.6639091323877766 0.0002483949379405992 0.3093723323884261 0.003364622341195402 1 Q96SI1 Irak4 deficiency tlr2 4 0.847716648687521 3.648382710654559 0.0002638963302747932 0.32514499864157276 0.0035143807943232865 1 Initiation of nuclear envelope ne reformation 0.6202635813082482 3.648118089032717 0.0002641682207813467 0.3254184105810891 0.0035143807943232865 19 Q86XL3,O75531,Q99986,P30153,P14635,P63151,P42166,P02545,P06493,P20700,P50402,P42167,Q14739,Q14974 Rhobtb2 gtpase cycle 0.5781795562569159 3.64107790098189 0.0002714989639782672 0.332748592620736 0.003579942091394864 21 Q99832,Q9NYL9,P62995,Q16543,P78371,Q13838,P08238,P12814,P40227,Q8WWQ0,P07900,P38159,Q9UM54,Q16643,Q8IYB3,Q13618,P07910 Biosynthesis of epa derived spms 0.8417835311039178 3.6180300544183988 0.00029685393107925506 0.3574932917328356 0.003879932958842908 1 Cellular response to chemical stress 0.3498779356639235 3.611948825359654 0.00030390454729878336 0.36420976937590865 0.003937545873697293 100 Q06323,O43242,P28074,P62191,Q96HE7,P17980,P04179,P62333,P51665,P09601,P30519,P25788,Q13616,P49721,P35998,O00231,Q99460,P63208,P00390,P30044,O14818,Q9UL46,P48556,P28070,P49720,P30041,P20674,P00403,P30048,P32119,Q8TCT9,O75832,P25789,P43686,Q86X55,Q99436,P13073,P25787,P10606,Q15008,P42704,P07237,P25786,P53004,P20618,O00487,P28066,Q9UNM6,P62195,P60900,O00483,Q13618,Q13200,P61289,O00232 Dopamine clearance from the synaptic cleft 0.8389068680330799 3.603274021679474 0.0003142339473392042 0.37392315540091425 0.004036280875305307 1 Hiv infection 0.29938265361435284 3.5729189521231874 0.00035302404882031624 0.4090942211607634 0.004495776348224552 180 P52294,P06748,P62191,Q08945,P30876,P37198,P46060,Q99567,P24928,P25788,Q93034,P35998,O14818,P49792,P49790,P43487,O75475,Q9Y5B9,P57740,P62826,P35658,Q92621,Q9NRG9,Q99436,Q7Z3B4,Q9BW27,P52948,Q15008,P25786,O00487,O14980,P12270,P60900,Q13200,P61289,O43242,P28074,O00267,P62333,Q8N1F7,Q12769,O00231,Q9UI12,Q99460,P63208,Q8TEM1,Q8WUM4,Q09161,P12236,Q9UL46,P48556,P49720,Q10567,Q96CW1,P05141,O75832,P12956,P12235,P63010,Q9UNM6,P20618,Q06323,P17980,P49721,Q8WUM0,P28070,P78406,Q13177,Q15370,P25789,P25787,Q9BTX1,O94973,P28066,P18754,O00232,O75531,P51665,P62487,P04439,P39748,Q5SRE5,O43747,P43686,Q99816,P30419,Q9BXS5,P13010,O75694,Q8NFH4,P62195,Q14974,Q9UKX7 Transcriptional regulation by runx2 0.38819009766979107 3.563067853311186 0.00036654588537010646 0.4208845864997184 0.00456952659430966 67 O43242,P17980,P28074,P62191,P51665,P62333,P25788,P06493,Q13616,P49721,P35998,O00231,Q99460,P63208,O14818,P48556,P28070,P49720,O75832,P25789,Q96PK6,P43686,Q99436,P25787,Q15008,P11802,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Acyl chain remodeling of dag and tag -0.8381877022653891 -3.562962054763152 0.00036669370058506345 0.42101216630640237 0.00456952659430966 1 Q96AD5 S phase 0.3254572320711569 3.5620177009592333 0.0003680155646423877 0.42215182365296533 0.00456952659430966 123 Q06323,Q14683,P25205,O43242,P28074,P62191,P17980,P51665,P62333,Q9BRT9,P25788,Q13616,P49721,P35998,O00231,Q9UQE7,Q99460,P63208,P35249,O14818,P49643,Q9UL46,P48556,P28070,P49720,P33991,P28340,Q9NTI5,P30260,P39748,P35250,P12004,O75832,P25789,Q14566,P43686,P40937,Q99436,P25787,Q9UJX3,Q15008,P11802,Q9Y2S7,P33992,Q29RF7,P25786,O00487,P33993,P28066,Q9UNM6,O60216,P62195,P27694,P60900,P20618,Q13200,P61289,P49736,O00232 Ampk inhibits chrebp transcriptional activation activity -0.9385572071785908 -3.556742453580671 0.0003754819408170462 0.4285470653459994 0.004623703238160333 2 Q96A54 Termination of o glycan biosynthesis -0.8360302049622607 -3.5517721479031543 0.00038264605743965063 0.4346169058352557 0.004673300209713778 1 Q11206 Cytoprotection by hmox1 0.3618544311767146 3.548668928759088 0.0003871835549609237 0.4384279575666678 0.004690272332453478 86 Q06323,O43242,P28074,P62191,P17980,P51665,P62333,P09601,P30519,P25788,Q13616,P49721,P35998,O00231,Q99460,P63208,O14818,Q9UL46,P48556,P28070,P49720,P20674,P28072,P00403,Q8TCT9,O75832,P25789,O75880,P43686,Q86X55,Q99436,P13073,P25787,P10606,P67870,Q15008,P42704,P19784,P25786,P53004,O00487,O00483,P28066,Q9UNM6,P62195,P60900,P20618,Q13618,Q13200,P61289,O00232 Regulation of glucokinase by glucokinase regulatory protein 0.49693334799554006 3.5457029390083012 0.0003915673506080797 0.4420855307986938 0.00470512380972613 30 Q99567,Q8N1F7,Q12769,Q8TEM1,P49792,Q8WUM0,P49790,P78406,P57740,P35658,Q92621,Q5SRE5,Q9NRG9,Q7Z3B4,Q9BTX1,Q9BW27,P52948,P12270,O75694,Q8NFH4,Q9UKX7 Citric acid cycle tca cycle 0.5648041792071011 3.543227591458277 0.00039526142744006343 0.44514915555571105 0.004711516215085567 21 P21912,P36957,Q96I99,O75390,P23368,Q9P2R7,P53597,Q13423,P07954,Q02218,P09622,O43837,P48735,P40926,P31040,P50213,Q99798 Mitotic g1 phase and g1 s transition 0.34241848292304566 3.519026507291357 0.00043313342920914266 0.47560424143648905 0.0051219746787430475 100 Q06323,P25205,O43242,P28074,P62191,P17980,P51665,P62333,P25788,P06493,Q13616,P49721,P35998,O00231,Q99460,P63208,O14818,P49643,Q9UL46,P48556,P28070,P49720,P33991,P31350,P12004,O75832,P04183,P25789,Q14566,P43686,Q99436,P25787,P11802,Q15008,P33992,P25786,P11388,O00487,P33993,P28066,Q9UNM6,P62195,P30153,P27694,P60900,P20618,Q13200,P61289,P49736,O00232 G2 m checkpoints 0.32852307229135275 3.5092268342846555 0.0004494114409994143 0.4881755379643843 0.005239102197126336 115 Q06323,P25205,O43242,Q92878,P62191,P28074,O96028,P17980,P62333,P51665,P25788,P06493,P62258,P35998,O00231,Q99460,P49721,P35249,P31946,O14818,P49959,Q9UL46,P48556,P28070,P49720,P33991,Q04917,P62805,P27348,P35250,O75832,P63104,P25789,Q14566,P43686,P40937,Q99436,P25787,Q15008,P33992,P25786,O00487,P04637,P33993,P28066,Q14676,Q9UNM6,P62195,P27694,P60900,P20618,Q13200,P61289,P49736,O00232 Gluconeogenesis 0.5402589199685942 3.5088370713939243 0.0004500705243168923 0.48867814627523143 0.005239102197126336 22 P60174,P06744,P11498,P04406,P00558,P00505,P18669,O75746,P40926,P04075,Q9UJS0,P17174,P06733,P40925,Q9UBX3,Q02978 Folding of actin by cct tric 0.8325832583258023 3.4980000605550843 0.0004687610261941977 0.5027277838397468 0.005414371542863225 8 P17987,Q99832,P40227,P48643,P50991,P50990,P49368 Clec7a dectin 1 signaling 0.38354983601161385 3.479937721410538 0.0005015303523325798 0.5264357479201545 0.005599867457331899 65 O43242,P17980,P28074,P62191,P51665,P62333,P61081,P25788,Q13616,P49721,P35998,O00231,Q99460,P63208,O14818,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Nr1h2 nr1h3 regulate gene expression linked to gluconeogenesis -0.8214670981661438 -3.4758367545600364 0.0005092621751425774 0.5318628267693668 0.005599867457331899 1 P28702 Nr1h2 nr1h3 regulate gene expression linked to triglyceride lipolysis in adipose -0.8214670981661438 -3.4758367545600364 0.0005092621751425774 0.5318628267693668 0.005599867457331899 1 P28702 Nr1h2 nr1h3 regulate gene expression to limit cholesterol uptake -0.8214670981661438 -3.4758367545600364 0.0005092621751425774 0.5318628267693668 0.005599867457331899 1 P28702 Cytokine signaling in immune system 0.2709261063951351 3.4741282181649673 0.0005125160635943704 0.5341281547247099 0.005599867457331899 243 P52294,P21333,P62191,Q9Y3Z3,P37198,Q99567,P25788,Q93034,P35998,P38919,O14818,P49792,P60953,P27824,P49790,P51452,P11233,P28072,P57740,P60842,Q15418,P35658,Q92621,Q9NRG9,Q99436,P07900,Q7Z3B4,Q9BW27,P62993,P52948,Q15008,O75369,P38646,P07237,P25786,O00487,P14625,P12270,P52597,P30153,Q6L8Q7,P60900,Q13200,P61289,P17987,P18031,P26038,O43242,P28074,P62333,P61081,Q8N1F7,P22626,Q12769,P20700,Q14738,Q13616,O00231,Q99460,P63208,Q8TEM1,Q9UL46,P48556,P49720,P61221,P78417,P14174,P05556,O75832,Q04637,P41240,P19525,Q9UNM6,P08670,P20618,Q13126,Q06323,P17980,P07355,P09601,P49721,Q8WUM0,P04083,P28070,P78406,Q13177,P52907,Q15370,Q16658,P25789,P09429,P25787,Q9BTX1,O43432,O14979,P52292,P28066,P46109,O00232,P51812,P11142,P05388,P04179,P51665,P37837,P40222,P23528,P10321,P04439,P55265,P63104,P51532,Q5SRE5,P43686,P42224,Q14258,P04637,O75694,Q8NFH4,P62195,P09661,Q14974,P78344,Q9UKX7 Ptk6 promotes hif1a stabilization -0.8209277238403617 -3.4730107245315947 0.000514654789790292 0.5356111469410652 0.005599867457331899 1 P00533 Erbb2 activates ptk6 signaling -0.8209277238403617 -3.4730107245315947 0.000514654789790292 0.5356111469410652 0.005599867457331899 1 P00533 Tfap2 ap 2 family regulates transcription of cell cycle factors -0.9205178924654135 -3.4727762004655918 0.0005151046908360435 0.535922507137538 0.005599867457331899 2 P01106,Q9UGL1 Interleukin 12 signaling 0.4880400896498478 3.4709371160596634 0.0005186454423569131 0.5383656623748052 0.005599867457331899 30 P17987,P26038,P05388,P04179,P07355,P22626,P20700,P37837,P60953,Q9UL46,P23528,P78417,Q13177,P14174,P52907,O14979,P38646,P07237,P52597,P09661,Q13126 Activation of ras in b cells -0.8194893923049428 -3.465469855796633 0.0005293058597897193 0.5456441273173204 0.005673854180479735 1 P01111 Apoptotic execution phase 0.4410908204745802 3.446900667453833 0.0005670570331142155 0.570509058005125 0.006035106995287018 39 P52294,P35611,P20700,Q9UKV3,Q14126,P16403,O00429,P26583,P10412,P02545,P16402,Q13177,P51572,Q13813,P07305,Q07157,Q15149,O00273,P09429,P15924,P35222,P08670,Q14974 Snrnp assembly 0.41724863494416614 3.435888700664739 0.0005906135521236422 0.5853307934242334 0.006125937935784455 48 Q9BQA1,Q16637,P37198,Q8N1F7,Q12769,Q99567,Q8TEM1,P57678,Q09161,P49792,Q8WUM0,P49790,P78406,Q9UHI6,P62314,P57740,P62318,P35658,Q92621,P62304,Q5SRE5,Q9NRG9,Q7Z3B4,Q9BTX1,Q9BVL2,P52948,Q9BW27,P62316,Q8TEQ6,P12270,O75694,Q96EE3,Q8NFH4,Q9UKX7,O14744 Transport of mature mrnas derived from intronless transcripts 0.42979711372782475 3.4356135019102454 0.0005912137531995931 0.58570168522722 0.006125937935784455 43 Q99567,P37198,Q12769,Q8N1F7,Q92797,Q9UBU9,Q9UKF6,Q8TEM1,Q09161,P49792,Q8WUM0,Q6UN15,P49790,P78406,Q86V81,P57740,P35658,Q92621,Q5SRE5,Q9NRG9,Q10570,Q7Z3B4,Q9BTX1,Q9BVL2,P52948,Q9BW27,P06730,P12270,O75694,Q96EE3,Q8NFH4,Q9P2I0,Q9UKX7 Defensins -0.813736066163267 -3.43523647760679 0.0005920369548677584 0.5862098402420124 0.006125937935784455 1 P35030 Alpha defensins -0.813736066163267 -3.43523647760679 0.0005920369548677584 0.5862098402420124 0.006125937935784455 1 P35030 Purine ribonucleoside monophosphate biosynthesis 0.7600462680936293 3.4021386322573335 0.0006686071235895152 0.6308520637760361 0.0068705145803336495 10 P22234,P30520,Q06203,P31939,P49915,P22102,P12268,O15067 Regulation of signaling by nodal -0.8022294138799154 -3.374431275192746 0.0007396838285651519 0.6679722466530338 0.007548828113438889 1 P36896 Reelin signalling pathway -0.8967811544686494 -3.3609527889692767 0.0007767410111036988 0.6858214480013112 0.00783984318114182 2 P98155,P06241 Oxidative stress induced senescence -0.45715684837034 -3.3602489505583137 0.0007787226783952939 0.6867484697670598 0.00783984318114182 41 O00257,O00716,O95819,P84243,Q9UPQ9,Q15910,P45984,P05412,Q8N4C8,Q8IW41,O14733,P49137,Q8NDV7,P45985,Q9UL18,P46734,Q8N257,O95503,Q16644,P45983,P35226,P52564,Q06587 Signaling by the b cell receptor bcr 0.37215837186670275 3.354397363219167 0.0007953805380349621 0.6944337179044993 0.00795380538034963 65 O43242,P17980,P28074,P62191,P51665,P62333,P25788,Q13616,P49721,O00231,P35998,Q99460,P63208,O14818,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,P62993,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Butyrophilin btn family interactions -0.7955771305286028 -3.3390701420953213 0.0008405933624335837 0.7143565202626889 0.008349894066840275 1 Q7KYR7 Viral messenger rna synthesis 0.4237800437102709 3.329977885501562 0.0008685288185263929 0.7260118030197955 0.008548414489049371 41 P30876,Q99567,P37198,Q12769,Q8N1F7,P24928,P19387,Q8TEM1,P49792,Q8WUM0,P49790,P78406,P62487,P57740,P35658,Q92621,Q5SRE5,Q9NRG9,Q7Z3B4,Q9BTX1,Q9BVL2,P52948,Q9BW27,P12270,O75694,Q96EE3,Q8NFH4,Q8NFH3,P19388,Q9UKX7 Beta catenin independent wnt signaling 0.3583977451868946 3.328850175765125 0.0008720530217016798 0.7274480080416079 0.008548414489049371 73 Q9HCE1,P17980,P28074,P62191,O43242,P51665,P62333,P25788,P49721,P35998,O00231,Q99460,O14818,Q9UL46,P07737,P48556,P28070,P49720,Q00610,Q14160,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,P63010,O00487,P35222,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Sumoylation of sumoylation proteins 0.4587598580171788 3.3217664332927956 0.0008944953685987578 0.7364189968165442 0.008691560438260377 32 Q99567,Q8N1F7,Q12769,Q8TEM1,P49792,Q8WUM0,P49790,P78406,P57740,P35658,Q92621,Q5SRE5,Q9NRG9,Q7Z3B4,Q9BTX1,Q9BW27,P52948,P12270,O75694,Q8NFH4,Q9UKX7 Transport of the slbp dependant mature mrna 0.43472428871060376 3.3205749484971596 0.0008983223540215413 0.7379190543717169 0.008691560438260377 36 Q99567,P37198,Q12769,Q8N1F7,Q9UBU9,Q8TEM1,Q09161,P49792,Q8WUM0,P49790,P78406,Q86V81,P57740,P35658,Q92621,Q5SRE5,Q9NRG9,Q7Z3B4,Q9BTX1,Q9BVL2,P52948,Q9BW27,P06730,P12270,O75694,Q96EE3,Q8NFH4,Q9UKX7 G alpha 12 13 signalling events -0.5290834087241946 -3.3051754437511867 0.0009491696428920449 0.7570584453876756 0.009124275921994504 24 Q9NZN5,O15085,P62879,Q9HAV0,Q8N5V2,O15013,Q6ZSZ5,P08134,Q12979,Q7Z628,P52735 Ub specific processing proteases 0.3217911454587345 3.2860812325968234 0.001015917077150874 0.7800787764018683 0.009703310544582077 102 Q06323,O43242,P28074,P62191,P17980,P51665,P62333,P45880,Q9NZL9,P25788,Q96FW1,P49721,P35998,O00231,Q9Y3E5,Q99460,P54578,Q86UV5,Q14694,O14818,Q8IXI2,Q9UL46,P48556,P28070,P49720,Q9Y277,O94826,Q93008,Q9Y265,Q14318,O60493,O75832,P25789,P21796,P43686,Q99436,P25787,Q15008,P45974,P25786,O00487,P04637,P28066,Q9UNM6,Q93009,Q92890,P62195,P60900,P20618,P14735,Q13200,P61289,O00232 Mitotic metaphase and anaphase 0.27550044354299147 3.2806406467601086 0.0010357161122547254 0.7864782817910779 0.009829407689551225 188 Q14683,P62191,P53350,Q14008,P46060,P37198,P25788,P35998,Q9UQE7,O14818,P49792,Q99986,P43034,P28072,Q9NTI5,P57740,P62826,Q99661,Q9Y6G9,P30260,Q92621,Q9P258,P14635,Q99436,Q7Z3B4,Q9BW27,P52948,Q15008,Q29RF7,P25786,O00487,O14980,P42166,Q15691,P30153,P60900,Q13200,P61289,O43242,P28074,Q9Y266,P62333,Q8N1F7,Q12769,P20700,Q14738,O00231,Q99460,Q15005,Q9UL46,P48556,P49720,P02545,O75832,Q9UJX3,Q9UNM6,P20618,O43684,Q92973,Q86XL3,Q06323,P17980,P49721,Q14739,Q8WUM0,P28070,Q9BUF5,P50402,Q9UJX4,P25789,P63151,P25787,Q9BTX1,P28066,P18754,O43264,O00232,O75531,P51665,P06493,Q8N3U4,P42167,Q5SRE5,P43686,O75694,O60216,Q8NFH4,P62195,Q14974,Q9UJX2,Q14204 Pyruvate metabolism and citric acid tca cycle 0.41813368509057064 3.2758668873145114 0.0010533819629898744 0.7920310247677982 0.009933791929461484 41 P21912,P36957,P08559,Q15120,Q96I99,P23368,P53597,O43837,P07195,O75390,P11177,Q6P587,Q9P2R7,Q04760,Q13423,P09622,P21796,P40926,P31040,P53985,P35613,Q99798,P07954,P48735,P00338,P50213,P10515,Q02218 Signaling by membrane tethered fusions of pdgfra or pdgfrb -0.782991729593687 -3.2717476915005523 0.001068849163197605 0.7967740727809823 0.010016259453864359 1 Q13439 Chylomicron remodeling -0.8771803632440487 -3.267438153347437 0.0010852557555560693 0.8016870929896689 0.010106444223615906 2 P02656,P04114 Rhobtb1 gtpase cycle 0.5271020018717681 3.261612215096206 0.0011078057609270608 0.8082466845907226 0.010252363874418151 21 Q13098,Q99832,P62995,P61201,Q7Z6E9,P78371,Q8N684,Q16643,P08670,P38159,Q9UM54,Q96T58,Q8IYB3,Q13618,P07910,Q9BT78 Postmitotic nuclear pore complex npc reformation 0.4914348856913785 3.258638289995727 0.001119483002774313 0.8115578163103737 0.010296479469961284 25 P37198,P46060,Q12769,Q8N1F7,Q8WUM0,P57740,P62826,Q92621,Q5SRE5,Q7Z3B4,Q9BTX1,Q9BVL2,P52948,Q9BW27,P18754,O75694,Q8NFH4,Q14974,Q92973 Sodium proton exchangers -0.7788565264293575 -3.249505378929946 0.0011560589187284975 0.8215638114423495 0.01056765514665928 1 Q92581 Intrinsic pathway of fibrin clot formation 0.8606365761553694 3.237520930672827 0.001205730945726291 0.8343077375727621 0.010954506763001068 2 Q07021 Tfap2a acts as a transcriptional repressor during retinoic acid induced cell differentiation 0.9165467625899282 3.2314869548121403 0.0012314794501002702 0.8405516338868375 0.011120632609996389 3 P06748,P10809 Cs ds degradation 0.857219924474017 3.221168365159216 0.0012766912301271915 0.8509517608992913 0.011418832170281668 2 P07686 Tcf dependent signaling in response to wnt 0.33762227242791165 3.220464854886214 0.0012798288405617697 0.8516478287255591 0.011418832170281668 83 O43242,P28074,P62191,P17980,P51665,P62333,P25788,Q14738,P49721,P35998,O00231,Q99460,O14818,P48556,P28070,P49720,P62805,Q9Y265,O75832,P63104,P51532,P25789,P43686,Q99436,P25787,Q15008,Q6P1J9,P25786,O00487,O14980,P35222,P28066,Q9UNM6,P62195,P30153,P60900,P20618,Q13618,Q13200,P61289,O00232 Sumoylation of rna binding proteins 0.4104763113665613 3.2020432047851424 0.0013645653014564552 0.8692660296272263 0.01210239463791738 41 Q99567,Q8N1F7,Q12769,Q9Y2X3,Q8TEM1,P49792,Q8WUM0,P49790,P78406,P57740,P35658,Q92621,Q5SRE5,Q9NRG9,Q7Z3B4,Q9BTX1,Q9BW27,P52948,P61978,P12270,O75694,Q8NFH4,P07910,Q9UKX7 Signaling by interleukins 0.28550139661659835 3.178726734453214 0.0014792347573422404 0.8898256930523831 0.013041773896094318 154 P17987,P26038,P11142,O43242,P28074,P62191,P17980,P05388,P51665,P62333,P07355,P09601,P22626,P25788,P20700,Q14738,Q13616,P35998,O00231,Q99460,P63208,P49721,P37837,O14818,P60953,P27824,P51452,P48556,P04083,P28070,P49720,P40222,P23528,P78417,P14174,P05556,P52907,Q16658,O75832,P63104,P51532,P25789,P43686,Q99436,P09429,P07900,P25787,P62993,Q15008,O14979,P38646,P07237,P25786,O00487,P09661,P04637,P28066,P14625,Q9UNM6,P62195,P08670,P52597,P30153,P46109,P60900,P20618,Q13126,Q13200,P61289,O00232 Neutrophil degranulation 0.2520547951874389 3.1579780724109257 0.0015886750727502896 0.9064265087872705 0.01392426975528196 242 P06744,P13798,P35998,Q96JM3,O00571,Q01518,P53396,P04080,P30041,P18669,P14618,P46940,Q9Y6G9,Q12905,Q9UQ80,P00387,P08238,P11279,Q99436,P07900,O60610,Q15008,O00487,P13639,Q86VP6,Q13200,O43242,P61106,Q92820,O00231,Q99460,Q5T4S7,Q13162,Q8NF37,P51149,P07686,P14923,P14174,P31949,P17858,P12956,P50395,P10619,O43681,P06280,Q96CS3,P10253,Q9BTY2,Q9UNM6,Q07065,P00491,P15586,P20618,Q14019,P16278,P17980,P42785,P39656,P07437,P07355,P30519,Q8NBS9,Q93050,P55072,P51148,P11216,P53618,O75131,Q7L576,Q96G03,P50990,Q13813,Q6IAA8,P09429,O75874,P25787,P07384,P61026,O00264,O94973,P11717,Q9P0L0,P28066,Q13510,P09960,Q7Z6Z7,P09972,O00232,P11142,P06737,Q9NP72,P51665,P61160,P18206,P36871,Q13217,Q9NZJ7,P78371,P10321,P07741,P04439,P04075,P67870,P15924,Q99536,P35573,P37108,Q9BXS5,P13010,P0DMV9,P12268,Q99829,Q14974,Q14204,Q92542 Metabolism of carbohydrates 0.2895295632339108 3.1338721774045237 0.0017251598783365463 0.9236714342654427 0.014953060321574299 135 P16278,P60174,P06744,Q01813,P06737,P11498,Q9UKX7,P52789,Q99567,Q8N1F7,Q12769,A6NDG6,Q14738,O95336,Q9UJS0,P37837,P36871,Q8TEM1,Q9UHD1,P06865,P11216,P49792,Q8WUM0,Q8TB61,P46926,P49790,P29401,P78406,P04406,P00558,P18669,Q7Z4W1,P14618,P07686,Q96G03,P04075,P57740,Q16851,P35658,P40925,P19367,Q92621,P17858,Q5SRE5,Q9NRG9,P52209,P40926,Q7Z3B4,Q9BW27,Q9BTX1,P52948,P17174,P54802,P11413,P35573,O43505,P10253,P15121,P14550,P00505,P51570,P12270,O75746,O75694,P08237,Q8NFH4,P30153,P15586,P06733,P09972,Q9UBX3,Q02978 Neurotransmitter clearance 0.8390577234310335 3.133708041036556 0.0017261250841011933 0.9237813172805434 0.014953060321574299 2 P05091 Regulation of hsf1 mediated heat shock response 0.3489400122529012 3.1243029996982266 0.0017822682189878591 0.9299081629862581 0.015350171365849201 67 P11142,O95757,Q8N163,Q9UL15,P37198,Q8N1F7,Q12769,P34932,Q99567,P25685,P62258,Q8TEM1,P49792,Q8WUM0,P49790,Q92598,P78406,P28482,Q02790,P57740,P35658,Q92621,Q99543,Q5SRE5,Q9NRG9,Q99615,Q7Z3B4,Q9BTX1,Q9BVL2,Q0VDF9,P52948,Q9BW27,P38646,P0DMV9,P12270,O75694,Q96EE3,Q8NFH4,P27694,P50454,Q9UKX7 Erythropoietin activates stat5 -0.837503120617726 -3.074772721194165 0.0021066302147043636 0.9568118833571297 0.018039534597181054 2 P51692 Abacavir metabolism 0.7382236605537537 3.0697733128230893 0.0021422129853059246 0.9590466268863536 0.018227208280135472 1 Blood group systems biosynthesis -0.8361805430678197 -3.0682710282044985 0.0021530125216804308 0.9597017422121027 0.018227208280135472 2 Q11206,Q9Y274 Rmts methylate histone arginines 0.47826340321367256 3.064254813358436 0.002182129612115169 0.9614163146033262 0.018369339672607926 23 Q99873,Q9BQA1,P61964,P51532,Q96GM5,Q8TAQ2,O96019,Q969G3,O14497,P62805,O60678,Q86U86,Q92922,P15880,Q86X55,P11802,O14744 Abacavir transmembrane transport 0.7351672060409884 3.0530380317571986 0.0022653722567409496 0.9659264454003179 0.018962947542382112 1 Interleukin 1 family signaling 0.33875268735815867 3.0380327461106096 0.002381280766685867 0.9713424854413564 0.01982183431487119 69 O43242,P17980,P28074,P62191,P51665,P62333,P25788,Q13616,P49721,P35998,O00231,Q99460,P63208,O14818,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P09429,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Aspartate and asparagine metabolism 0.8814321698452772 3.030296391113725 0.0024431385369680925 0.9738715501575679 0.020121480195879265 5 P17174,P08243,P00505,O75746 Chemokine receptors bind chemokines -0.8284481208416011 -3.030154435315646 0.0024442871915799635 0.9739163399922804 0.020121480195879265 2 Q9UK39,Q9ULM6 Activated ntrk3 signals through pi3k -0.736605537576426 -3.0186958495164826 0.0025386525534485394 0.9773456136940569 0.02061436801361652 1 P12931 Signaling by notch1 -0.48509527580954453 -3.0181699028344986 0.0025430628417835166 0.9774943718010224 0.02061436801361652 26 Q92793,Q09472,O15379,P62877,P24863,Q86YT6,P01106,Q92830,P49336,P49407,P49768,Q04727,Q9UBN7 Notch1 intracellular domain regulates transcription -0.5568549577374118 -3.012526882937691 0.0025908248761132846 0.9790441710086597 0.02061436801361652 19 Q92793,Q09472,P62877,P24863,Q92830,P01106,P49336,O15379,Q04727,Q9UBN7 Ncam1 interactions -0.7353469974829344 -3.011719426600543 0.0025977257972371604 0.9792590973510669 0.02061436801361652 1 P13591 Il 6 type cytokine receptor ligand interactions -0.8244919978421404 -3.0105835194470556 0.0026074622742493503 0.9795585946478909 0.02061436801361652 2 P29597,P23458 Fertilization -0.7349874145990797 -3.0097250675522162 0.002614842654076188 0.9797827345897386 0.02061436801361652 1 P15291 Defective b4galt1 causes b4galt1 cdg cdg 2d -0.7349874145990797 -3.0097250675522162 0.002614842654076188 0.9797827345897386 0.02061436801361652 1 P15291 Interaction with cumulus cells and the zona pellucida -0.7349874145990797 -3.0097250675522162 0.002614842654076188 0.9797827345897386 0.02061436801361652 1 P15291 Vldl clearance -0.8773381294964692 -2.9889970283001355 0.0027989485395409908 0.9846444860045573 0.02194964907324251 3 P98155,P02654,P04114 Transcriptional regulation of white adipocyte differentiation -0.44373190172519655 -2.964527632001228 0.0030314801680189074 0.989151904812078 0.023648719635330752 33 Q9Y3C7,P19838,P14672,Q92793,Q09472,Q9UHV7,Q6P2C8,Q9H944,P24863,P49336,Q96RS0,O15379,Q9BUE0,Q15528,P24468 Golgi to er retrograde transport 0.30498030610657867 2.9471593050987948 0.003207079366984722 0.991656122737811 0.024888272170871025 93 Q9P2W9,Q9NP72,Q9NZ32,P33176,Q14807,Q9H2M9,Q9Y678,P49755,P63167,O75396,Q9BVA1,P62820,Q9H0H5,Q13885,Q07866,P53618,Q9BUF5,Q12981,Q15363,P68371,P43034,Q15102,Q10472,Q10471,P53621,O75935,Q99747,Q99661,Q9Y6G9,O14579,P46459,P52907,Q96FJ2,Q6NUQ1,Q14203,Q12756,P35606,Q15042,Q9BW19,Q8TD16,P24390,Q9BVK6,O95235,P61923,Q9UBF2,Q9UJW0,Q13409,O95239,P52732,P54920,P48444,O00139,O15260,Q9Y3B3,P47755,P47756,Q9H0U4,P61163,O43264,Q92538,Q8N6T3,P18085,Q14204,Q13561,Q02241 Signaling by notch1 pest domain mutants in cancer -0.5121073560889435 -2.935999566947152 0.0033247478661924124 0.9930019784885062 0.0256677425939207 21 Q92793,Q09472,P62877,P24863,Q86YT6,Q92830,P49336,P49768,O15379,P01106,Q9UBN7 Terminal pathway of complement -0.7186263933836892 -2.9184630657667876 0.0035176154398288695 0.9947550366562817 0.026961722600580756 1 P10909 Inositol phosphate metabolism -0.5615213948856773 -2.917495483486102 0.0035285475886666084 0.9948400764616859 0.026961722600580756 18 Q14642,Q8N3E9,O43426,Q01970,P49441,Q92551,O95989,P16885,O43314 Signaling by gpcr -0.3409729298896572 -2.9099755286453632 0.0036145705632739666 0.9954628997057693 0.0273505010241486 94 Q14571,P08174,P48960,Q6ZSZ5,P49407,Q7Z628,P52735,P52429,Q9NZN5,Q96RR4,O15085,Q16566,Q3ZCW2,Q8N5V2,P16220,Q12979,O43665,Q9UK39,P01111,Q9HAV0,P62879,O15013,P00533,P08134,Q13164,P50148,O60658,P31323,P25098,Q01970,Q9Y243,P22466,P22694,P31321,O60266,Q9ULM6 Association of tric cct with target proteins during biosynthesis 0.4643553070260796 2.909839844053622 0.003616140068293472 0.9954735360106057 0.0273505010241486 22 P17987,Q99832,Q9Y2T2,P78371,P04637,P40227,P48643,O00567,P50991,P04062,P50990,P49368 Beta oxidation of octanoyl coa to hexanoyl coa 0.8528247571068837 2.9002892600973817 0.0037281843845620166 0.99617185743899 0.02792611945106159 5 P30084,P11310,P55084,Q16836 Dna strand elongation 0.40110661631746725 2.9001593432323878 0.0037297300474907757 0.996180696574278 0.02792611945106159 34 P40938,P25205,P09884,Q9BRT9,P35249,P49643,P33991,P28340,P39748,P35250,P12004,Q14566,P40937,Q9BRX5,Q9Y2S7,P33992,P35251,P33993,P27694,P49642,P49736 Signaling by alk in cancer 0.37841183007363166 2.8875189854230614 0.003882931717942073 0.9969628323883581 0.028792363369076344 41 P26038,P06748,Q9NR09,P33176,P26641,P10644,P67936,P18206,Q13616,P35579,P63208,P49792,Q07866,Q00610,P28482,P62753,P51608,Q92734,Q9HC35,O94979,Q14203,P49589,Q9P2E9,P40763,P62993,P06753,P31939,Q86WB0,P12270 Digestion 0.7049622437971904 2.885865103543042 0.0039033942285593426 0.9970543866299505 0.028792363369076344 1 Digestion and absorption 0.7049622437971904 2.885865103543042 0.0039033942285593426 0.9970543866299505 0.028792363369076344 1 Creatine metabolism 0.838719710023111 2.8760197008052124 0.0040272457531178585 0.9975525574305318 0.029559587054904485 3 P12532 Sumoylation of ubiquitinylation proteins 0.39214243978075985 2.866079917346972 0.004155893171939207 0.9979810623391236 0.030354317775438327 35 Q99567,Q8N1F7,Q12769,Q8TEM1,P49792,Q8WUM0,P49790,P78406,P57740,P35658,Q92621,Q5SRE5,Q9NRG9,Q7Z3B4,Q9BTX1,Q9BW27,P52948,P12270,O75694,Q8NFH4,Q9UKX7 Metabolism of nucleotides 0.33188582862941185 2.859716182623358 0.0042402030362374 0.9982203438427398 0.030819036702408428 62 P23921,P36639,Q9Y3Z3,Q9NRF8,P55263,P23919,P54819,Q9H773,P22102,P15531,P00390,O15067,P22234,P30520,Q06203,Q9BY32,Q9UKK9,P11172,P49902,P07741,Q16881,P31350,P00568,P30085,P30566,P17812,P04183,P49915,P00492,Q05682,P33316,P31939,P27708,P12268,P00491,O43598 Nuclear envelope ne reassembly 0.3311682423119259 2.8515786520711015 0.0043502722454946685 0.9984906039823996 0.03146556138731581 62 Q86XL3,O75531,P37198,Q8N1F7,Q12769,P46060,P06493,P20700,Q8WUX9,Q9BVA1,Q14739,Q13885,Q8WUM0,Q99986,Q9BUF5,P68371,Q9Y2U8,P02545,P50402,P57740,P62826,P42167,Q8NC56,Q92621,Q5SRE5,P14635,P63151,Q7Z3B4,Q9BTX1,Q9BVL2,P53990,P52948,Q9BW27,Q8NFH5,P18754,O75694,Q9UN37,P42166,Q96EE3,Q8NFH4,Q8NFH3,P30153,Q14974,Q92973 Trna processing in the nucleus 0.3474355911914644 2.846055688282244 0.00442644531411962 0.9986532268857261 0.03186185274414607 53 Q99567,P37198,Q12769,Q8N1F7,Q8TEM1,P49792,Q8WUM0,P49790,P78406,P33240,Q9Y3I0,Q92499,Q9Y224,P57740,P62826,P35658,Q92621,Q9BQ52,Q5SRE5,Q9NRG9,Q10570,Q99575,Q7Z3B4,Q9BTX1,Q9BVL2,P52948,Q9BW27,P78346,P12270,O75694,Q96EE3,O43592,Q8NFH4,Q9UKX7 Norepinephrine neurotransmitter release cycle -0.8449449578179948 -2.8368711068824912 0.004555799958469775 0.9988902846865152 0.03196006370546223 3 O14795,P20336 Serotonin neurotransmitter release cycle -0.8449449578179948 -2.8368711068824912 0.004555799958469775 0.9988902846865152 0.03196006370546223 3 O14795,P20336 Acetylcholine neurotransmitter release cycle -0.8449449578179948 -2.8368711068824912 0.004555799958469775 0.9988902846865152 0.03196006370546223 3 O14795,P20336 Passive transport by aquaporins 0.6961524631427495 2.836487204095518 0.0045612806086319235 0.9988993510690711 0.03196006370546223 1 Defects of contact activation system cas and kallikrein kinin system kks 0.6957928802588947 2.8344657826352258 0.00459023733756303 0.9989460383271752 0.03196006370546223 1 Gamma carboxylation transport and amino terminal cleavage of proteins 0.6957928802588947 2.8344657826352258 0.00459023733756303 0.9989460383271752 0.03196006370546223 1 Defective factor ix causes hemophilia b 0.6957928802588947 2.8344657826352258 0.00459023733756303 0.9989460383271752 0.03196006370546223 1 M phase 0.22235278230334748 2.8183727099060274 0.004826774510682252 0.9992603303578073 0.03345066986472817 277 Q14683,P62191,P53350,Q9NTJ3,P37198,P46060,Q99567,Q14008,P25788,P35998,Q9UQE7,O14818,P49792,Q99986,O95347,P49790,P43034,P28072,Q9NTI5,P57740,Q9BPX3,Q99661,Q9Y6G9,P30260,P62826,P35658,Q92621,Q9P258,P14635,Q9NRG9,Q99436,P07900,Q7Z3B4,Q9BW27,Q9BSJ2,P52948,Q15008,P19784,O00139,Q29RF7,P25786,O00487,O14980,P12270,P61163,P42166,Q15691,P30153,P60900,Q13200,Q15021,P61289,O43242,P28074,Q9Y266,P62333,Q8N1F7,Q12769,P20700,Q14738,P62258,O00231,Q99460,Q8TEM1,Q15005,O60763,Q9UL46,P48556,P49720,P28482,Q9Y2U8,P02545,Q7Z5K2,O75832,Q14203,Q9UJX3,Q9H1A4,Q9UNM6,P20618,Q13561,O43684,Q92973,O94927,Q86XL3,Q06323,P30154,P17980,P07437,P49721,Q14739,P62820,Q8WUM0,P28070,Q9BUF5,P78406,P62805,O75935,P50402,Q9HC35,Q9UJX4,P25789,P63151,P25787,Q9BVL2,Q9BTX1,P53990,P28066,P18754,O43264,Q96EE3,O00232,Q02241,Q8TD19,O75531,P51665,Q9H6D7,Q01105,P06493,P63167,Q9BVA1,Q15003,Q15154,Q8N3U4,Q2NKX8,P42167,O95684,Q6KC79,P61981,Q5SRE5,P43686,Q14980,P67870,O60566,O75694,O60216,Q8NFH4,P62195,Q14974,Q9UJX2,Q14204,Q9UKX7 Acyl chain remodeling of cl 0.825239132310645 2.8129410263053387 0.004909065349303354 0.9993460764061033 0.03386346004843518 3 P55084 Metabolism of angiotensinogen to angiotensins -0.8385066719574265 -2.8062925224315363 0.005011517437998991 0.9994390813296643 0.03441088010423271 3 Q9BYF1,Q9UBR2 Cellular response to heat stress 0.3069664141792397 2.8039323674914693 0.005048349358552695 0.9994691821530174 0.03450477313873173 79 P11142,O95757,Q8N163,Q9UL15,Q99567,P37198,Q8N1F7,P34932,Q12769,P25685,P62258,Q8TEM1,P55072,P49792,Q8WUM0,P49790,Q92598,P78406,P15927,P28482,Q02790,P57740,P35658,Q92621,Q99543,P08238,Q5SRE5,Q9NRG9,P07900,Q99615,Q7Z3B4,Q9BW27,Q0VDF9,P52948,Q9BVL2,Q9BTX1,P38646,P42345,P0DMV9,P12270,Q15185,O75694,Q96EE3,Q8NFH4,P27694,P50454,Q9UKX7 Activation of the phototransduction cascade -0.6972312117943323 -2.7975666055570025 0.005148914990748654 0.999543399776296 0.034872196982797705 1 P62873 Sensory perception of taste -0.6972312117943323 -2.7975666055570025 0.005148914990748654 0.999543399776296 0.034872196982797705 1 P62873 Activation of the tfap2 ap 2 family of transcription factors -0.8350610929493587 -2.789880430811208 0.00527275102129976 0.9996207005413394 0.0355493168404373 3 Q92793,Q09472 Pou5f1 oct4 sox2 nanog activate genes related to proliferation 0.6864437252786716 2.78174308434231 0.005406782293203349 0.9996896975972913 0.036288764039968426 1 Release of hh np from the secreting cell -0.6929162171880755 -2.7729674761055185 0.00555476721288084 0.9997514026233381 0.03654177773883246 1 P78536 Signaling by notch1 t 7 9 notch1 m1580 k2555 translocation mutant -0.6929162171880755 -2.7729674761055185 0.00555476721288084 0.9997514026233381 0.03654177773883246 1 P78536 Runx3 regulates yap1 mediated transcription -0.8314748201439401 -2.7727629795212585 0.005558258844521102 0.9997526997894371 0.03654177773883246 3 Q15561,P28347,P46937 Yap1 and wwtr1 taz stimulated gene expression -0.8314748201439401 -2.7727629795212585 0.005558258844521102 0.9997526997894371 0.03654177773883246 3 Q15561,P28347,P46937 Developmental biology 0.20969662355825452 2.772245513511669 0.005567103051486555 0.9997559552907184 0.03654177773883246 388 Q96P70,P05387,P62191,P30876,P60660,P46777,Q02543,P24928,P25788,P26373,P35579,P08865,P35998,P62277,P62249,P46783,P38919,O14818,Q01518,P60953,Q00610,P35659,Q07020,P62241,Q9Y3U8,Q9Y490,P15880,P61247,P62753,Q15022,P62269,P50570,P35241,P36578,P08238,P83731,P62917,P62701,Q99436,P07900,P18077,P62993,P11802,Q15008,P25786,O00487,P60900,P11940,Q13200,P61289,P62263,P26038,O43242,P28074,Q9Y2W1,P15311,O60271,P62333,Q13617,P42766,O00231,Q99460,Q14126,Q09161,Q14966,Q9UL46,P48556,P49720,Q96CW1,P63173,P14923,P05556,P23396,O75832,P35580,Q04637,Q01082,P63010,Q9UNM6,P18621,P62910,P62899,P46778,P46776,P20618,Q92769,P08708,Q06323,P17980,P62750,P49721,Q13573,P28070,P46782,P83881,Q9BUF5,O15145,P62805,P40429,Q13177,Q13813,Q15370,P61313,Q16555,P25789,P62244,P62847,P46939,P61353,Q86X55,P30050,P25787,P18124,P07384,O95239,Q16850,P60866,O94973,P62280,P28066,P61927,P61158,O00232,P35221,P13861,P11142,P05388,P51812,P51665,P61160,P50914,P62081,P62266,P47914,P07737,P23528,P62888,P62487,P15170,P32969,P62913,P51532,P84098,P62829,P62424,P35268,P43686,P46781,P27635,Q02878,P59998,P39019,P62495,P15924,P35222,P46779,P49207,P62851,P62195,P62906,P39023 Mitochondrial calcium ion transport 0.49695467074623345 2.767786172801406 0.005643847150830439 0.9997824653511043 0.03665734097981915 19 Q99623,O75439,Q10713,P35232,Q9Y277,Q9Y4W6,P45880,P21796,Q96TA2,Q9UJZ1,Q92667,O95202,Q9BPX6 Hydrolysis of lpc 0.6839266450916884 2.7674938439571886 0.005648911230465847 0.9997841098274646 0.03665734097981915 1 Transcriptional regulation by small rnas 0.35334719591266733 2.7669400642701203 0.00565851572171705 0.9997871946799608 0.03665734097981915 47 P30876,Q99567,Q8N1F7,P24928,Q8TEM1,P49792,Q8WUM0,P49790,P78406,P62487,P62805,O15397,P57740,P62826,P35658,Q92621,Q9NRG9,Q7Z3B4,Q9BTX1,Q9BW27,P52948,P12270,O75694,Q9UKX7 Regulation of lipid metabolism by pparalpha -0.3864774558545046 -2.764359301678221 0.005703469806041861 0.9998010579700133 0.036788614766244045 48 P08047,Q9Y3C7,P11474,Q9BUE0,Q92793,Q09472,O15379,Q9UHV7,O75192,Q6P2C8,P25208,P49336,P24863,P13196,Q99541,P28702,Q15528,O60427 Pre notch expression and processing -0.45001986626731805 -2.7460847663685035 0.006031117847896894 0.9998782540378205 0.038575158676724584 27 Q8N257,Q9UPQ9,Q9Y274,Q92793,P05412,Q11206,Q09472,Q8NDV7,Q92830,O00716,Q9UL18,P41743 Mrna decay by 3 to 5 exoribonuclease 0.5441961832497463 2.74602466687601 0.006032222799783105 0.9998784555271395 0.038575158676724584 16 Q6PGP7,Q13868,Q9GZS3,Q5RKV6,Q96C86,Q9Y2L1,Q9NQT4,Q9Y450,Q9NQT5,Q15477,Q969T7,Q15024 Interleukin 2 signaling -0.8246402877698378 -2.740041597336768 0.0061431408910854746 0.9998970750573649 0.039070930848777226 3 P23458,P51692,P29353 Defective ext2 causes exostoses 2 -0.6869830996044723 -2.739023663770474 0.006162193791585668 0.999899973471054 0.039070930848777226 1 Q93063 Runx1 regulates transcription of genes involved in differentiation of keratinocytes -0.7699601731556583 -2.7359137038340737 0.006220733715982973 0.9999083783551622 0.03927497134243488 2 P07711 Josephin domain dubs 0.8074103775265284 2.728819377804211 0.006356150775041591 0.999925214855265 0.039960610357856426 3 P55072 Ticam1 dependent activation of irf3 irf7 -0.6846458108594166 -2.725613553529977 0.006418209499096772 0.9999318604803021 0.04018122753636215 1 Q9UHD2 Condensation of prometaphase chromosomes 0.623281951405453 2.7219396521286616 0.006489999284032155 0.9999388153877307 0.04046066499250173 11 O95347,Q9BPX3,P14635,Q9NTJ3,P06493,P67870,Q15003,Q15021 Beta oxidation of lauroyl coa to decanoyl coa coa 0.8526713437668642 2.7087132519292525 0.006754468895833199 0.9999588506122526 0.04193399439496445 4 P30084,P55084,Q16836 O glycosylation of tsr domain containing proteins -0.7642510339867163 -2.706617630587745 0.006797249683112572 0.9999614085475549 0.04202448974206528 2 Q9UHI8,Q9Y2G5 Foxo mediated transcription of cell death genes -0.8706601906818817 -2.7040535434518698 0.006849925046637617 0.9999643408675617 0.04217515834500021 4 Q92793,Q09472,P25208,O43524 Cellular hexose transport -0.8160443001404026 -2.6987000172409794 0.00696108927475847 0.9999698188113364 0.042568540191595276 3 P14672,Q9NY64 Nucleotide biosynthesis 0.5538824898563905 2.6982285870547655 0.006970955574999493 0.9999702623200579 0.042568540191595276 15 P22234,P30520,Q06203,P31939,P49915,P11172,P22102,P27708,P12268,O15067 Zinc influx into cells by the slc39 gene family -0.8151328827184116 -2.694304372021294 0.007053571943335335 0.9999737294840535 0.042897233451304695 3 Q92504,Q9ULF5 Estrogen biosynthesis 0.6699029126213537 2.6876787857436963 0.007195057319965503 0.9999787550046291 0.04357588244461485 1 Apoptotic cleavage of cellular proteins 0.41333628599201394 2.686353908832828 0.007223652995852259 0.9999796474869637 0.04357588244461485 27 P51572,Q15149,P35222,P02545,P35611,P20700,P08670,Q9UKV3,Q13813,Q14126,P15924 Common pathway of fibrin clot formation -0.6774541531823218 -2.6842152366410805 0.0072700286050420004 0.9999810159276982 0.043587921429314475 1 Q9UNN8 Protein repair 0.6691837468536442 2.683566166027465 0.007284155997247854 0.9999814142304679 0.043587921429314475 1 Separation of sister chromatids 0.2533396185102931 2.6762708223995193 0.007444646112414244 0.9999853931321276 0.0443700908299889 146 Q06323,Q14683,O43242,P28074,P62191,P53350,Q9Y266,P17980,P62333,P51665,Q14008,P46060,Q12769,P25788,Q14738,P49721,P35998,O00231,Q9UQE7,Q99460,Q15005,O14818,P49792,Q8WUM0,Q9UL46,P48556,P28070,P49720,Q9BUF5,P43034,Q8N3U4,Q9NTI5,P57740,Q99661,Q9Y6G9,P30260,O75832,Q9P258,Q9UJX4,P25789,P43686,Q99436,P25787,Q9BW27,Q9UJX3,P52948,Q15008,Q29RF7,P25786,P20618,O00487,O14980,P28066,Q9UNM6,O43264,Q15691,O60216,Q8NFH4,P62195,P30153,P60900,Q9UJX2,Q14204,Q13200,P61289,O43684,O00232 Retinoid cycle disease events -0.7561589642150922 -2.6649147403429914 0.00770078438812094 0.9999900563551577 0.04555672150016251 2 P09455,P29374 Hedgehog off state 0.3043014729523759 2.6647352622522167 0.007704895179893256 0.9999901175445195 0.04555672150016251 71 Q06323,P13861,P17980,P28074,P62191,O43242,P51665,P62333,P10644,P25788,Q13616,P49721,P35998,O00231,Q99460,P63208,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Loss of function of smad2 3 in cancer -0.7543607264880646 -2.6556188106889063 0.007916304187399081 0.9999928057515056 0.046256051918527975 2 Q13485,O95405 Runx3 regulates bcl2l11 bim transcription -0.7543607264880646 -2.6556188106889063 0.007916304187399081 0.9999928057515056 0.046256051918527975 2 Q13485,O43524 Foxo mediated transcription of cell cycle genes -0.7543607264880646 -2.6556188106889063 0.007916304187399081 0.9999928057515056 0.046256051918527975 2 Q13485,O43524 Regulation of foxo transcriptional activity by acetylation -0.8159010001597207 -2.6369967728257686 0.00836436273352037 0.9999963299859375 0.04868320497244279 5 Q92793,Q9NTG7,Q09472,O43524 Unfolded protein response upr 0.32738481882021186 2.6286897718406563 0.008571451553855969 0.9999973114609054 0.04950303624177333 53 Q13868,Q9Y2L1,Q15084,P35611,P05198,P43307,Q9HCU5,P61421,Q13217,P08243,Q9Y490,P02545,Q92945,P27797,Q15024,O94979,Q14203,Q9Y4L1,P20042,P51858,Q06210,Q9Y5M8,Q969H8,Q9NQT5,P14625,Q5RKV6,P08240,O14773,Q9NQT4,Q8N6T3,O95453 Cholesterol biosynthesis 0.42565455041768324 2.628681236241274 0.008571666678105716 0.9999973123299868 0.04950303624177333 23 Q16850,P48449,Q15392,Q01581,P14324,P37268,Q9BWD1,Q14739,Q13907 Hdl clearance 0.7369178205358715 2.6245705616597568 0.008675831390573485 0.9999977018162548 0.049911153559669866 2 Q00341 Interconversion of nucleotide di and triphosphates 0.424825677934793 2.6216744764986726 0.008749896161043047 0.9999979439376881 0.05004319835759295 23 P23921,P17812,P33316,Q9NRF8,P23919,P54819,Q9H773,P00390,P15531,Q16881,P31350,P00568,P30085 Ca2 pathway -0.5221611323226375 -2.6210493862908235 0.008765956222370308 0.9999979929785874 0.05004319835759295 18 Q14571,Q9UPQ9,Q13976,P62879,Q9HAV0,Q8NDV7,Q01970,Q9UL18,P01106 Cross presentation of particulate exogenous antigens phagosomes -0.6659475008989703 -2.6175469765055834 0.008856429694489076 0.9999982481928553 0.05029002695414075 1 P06756 Abacavir transport and metabolism 0.7352994065815468 2.616261326645718 0.008889849041291642 0.9999983340304097 0.05029002695414075 2 P49902 Vitamin c ascorbate metabolism 0.7836501389580823 2.615471039382035 0.008910447728787352 0.9999983848309448 0.05029002695414075 3 P00387 Dectin 2 family -0.7965669346363604 -2.6042473333106195 0.009207628347388974 0.9999989668705477 0.05177119334947009 3 P06241,P16885 Protein methylation 0.6854902769252613 2.5997082860746272 0.009330303735894052 0.9999991409291846 0.052250387902728235 7 P11142,P15880,P13639,P55072,P38117 Resolution of abasic sites ap sites 0.3792602279555677 2.598507903055639 0.009362988973173447 0.9999991821402487 0.052250387902728235 32 P40938,P18858,P27695,Q07864,Q86W56,P35249,Q9NX46,P49005,P09874,P35244,P15927,P28340,P39748,P35250,P12004,P18887,P40937,Q9Y2S7,P41440,Q9NR33,P35251,P49916,P29372,P27694 Acyl chain remodelling of pi 0.6522833513124716 2.5863689703510895 0.009699304030669209 0.9999995068766624 0.05392523509588479 1 The citric acid tca cycle and respiratory electron transport 0.25069699821708696 2.5843324248414605 0.009756770451327945 0.9999995477237308 0.05404307796460461 133 P06576,P21912,Q96I99,P08559,Q15120,P23368,P36957,Q9UDW1,P53597,P36542,O43837,Q12931,P08574,P07195,Q16718,P38117,O14949,O43676,O75251,Q9Y6M9,O75964,O75390,O96000,P49821,Q9BQ95,O95182,P20674,Q16795,P00403,Q9H845,O43819,Q6P587,P11177,Q9H9P8,Q04760,O75489,Q9P2R7,Q13423,P13804,O75880,O95299,Q9P032,P21796,O95168,P09622,P13073,P48047,P40926,P31040,P22695,P53985,P19404,P10606,P35613,Q99798,P42704,P31930,P25705,P07954,P56134,P48735,P00338,O75306,P50213,P28331,Q16134,P10515,P56385,Q02218,O00483,O75947,P24539 Negative regulation of tcf dependent signaling by dvl interacting proteins -0.6596548004315124 -2.5808619330382263 0.00985539882556008 0.9999996101033931 0.05438720092623897 1 O14641 Cell death signalling via nrage nrif and nade -0.4406565378846739 -2.5782596111610587 0.009929936352023105 0.9999996514746343 0.05459632902034845 25 Q9NZN5,P45983,O15085,Q8N5V2,O15013,Q6ZSZ5,P49768,Q12979,Q7Z628,P52735 Nrage signals death through jnk -0.49973284333459395 -2.569474780490872 0.01018528051366907 0.9999997626863255 0.05579436751973132 19 Q9NZN5,P45983,O15085,Q8N5V2,O15013,Q6ZSZ5,Q12979,Q7Z628,P52735 Apoptosis induced dna fragmentation 0.5971843760352213 2.563766108962187 0.010354329342208368 0.9999998160090809 0.056512639999598796 11 P52294,P16403,O00273,P26583,P10412,P09429,Q14974,P07305 Rna polymerase ii transcription termination 0.30983417788312206 2.5596902573218077 0.010476549238486177 0.9999998469350925 0.05697101593191389 58 O00148,Q9BY77,Q13838,Q8N684,Q05048,Q92797,Q9UKF6,P38919,Q09161,O43809,Q6UN15,Q05519,Q96FV9,Q86V81,P33240,Q8NI27,Q86W42,P62318,P62304,Q08170,Q13247,Q10570,O75152,Q86U42,Q07955,Q8IYB3,Q16629,P26368,Q9Y5S9,Q12996,Q92620,P82979,Q13243,P51003,Q9P2I0,Q96J01,P84103,Q13242 Beta oxidation of decanoyl coa to octanoyl coa coa 0.6997271821945147 2.5574337747542453 0.010544763422697612 0.9999998618771803 0.05713344545388888 6 P30084,P11310,P55084,Q16836 Elevation of cytosolic ca2 levels -0.7344002877180584 -2.5517298345639783 0.010718960017476853 0.9999998937493234 0.057866849369712 2 Q14571,Q13586 Synthesis of 5 eicosatetraenoic acids 0.6454512765192316 2.546776229577532 0.010872312584363497 0.9999999156637169 0.05848283664513218 1 Polymerase switching 0.5309912649020093 2.5437434660065064 0.010967159715815189 0.9999999268925913 0.05867583430366592 15 P40938,P35251,P09884,P28340,P40937,P12004,P35249,Q9Y2S7,P35250,P49643 Mrna editing c to u conversion -0.6530025170801997 -2.5419059521919616 0.01102498345563685 0.9999999329918393 0.05867583430366592 1 Q9NRW3 Ras signaling downstream of nf1 loss of function variants -0.7325174731117153 -2.5418632235012386 0.011026331278541246 0.999999933127771 0.05867583430366592 2 P01111 Translesion synthesis by polh 0.5612598994692993 2.535698781522656 0.011222321678262981 0.9999999502269866 0.05950626085626991 13 P40938,P35249,P35251,P15927,P40937,Q92890,P27694,P55072,P35250,Q8TAT6,P12004 Deadenylation dependent mrna decay 0.32212917758073245 2.5273024782772975 0.01149424594944537 0.9999999669622484 0.06073200873997731 52 Q13868,Q96F86,Q9Y2L1,Q9Y450,Q15477,P38919,Q969T7,Q9GZS3,Q6PGP7,Q92600,P23588,P60842,Q15024,Q04637,Q9NQT5,P26196,P62312,Q9Y333,Q06265,P06730,Q6P2E9,Q5RKV6,A5YKK6,Q96C86,Q9NQT4,P11940,O95453 Defective lfng causes scdo3 -0.6497662711255071 -2.522889265693391 0.011639504695701408 0.9999999734592155 0.06128219786782721 1 Q04721 Synthesis of lipoxins lx 0.6407766990291199 2.5195867988587186 0.011749266814500725 0.9999999775070522 0.061642280118331276 1 Mrna splicing minor pathway 0.3394173641671055 2.5143624241215914 0.011924781816277985 0.999999982737236 0.06223380029181307 42 O94906,Q9BUQ8,P30876,O75533,Q6P2Q9,P24928,P19387,Q09161,Q15427,Q86XP3,P62487,P62314,O75643,Q96DI7,Q15029,P62318,P67809,P62304,Q13247,Q13435,Q07955,Q15393,P62316,Q16629,Q9Y333,P55769,Q9Y3B4,P19388 Sumoylation 0.25570452328514776 2.513748809720706 0.011945548243931903 0.9999999832694553 0.06223380029181307 112 P06748,P26358,Q99567,P46060,Q8N1F7,Q12769,Q9Y2X3,P17844,Q99497,Q9UQE7,Q8TEM1,P49792,Q8WUM0,P09874,P49790,Q92841,P78406,P62805,Q9UBE0,P57740,Q15022,P35658,P12004,Q92621,Q9NRG9,Q02880,P11387,Q7Z3B4,Q9BW27,Q9BTX1,P52948,Q9UBT2,P11388,Q13263,P04637,P61978,P12270,O75694,Q14676,O60216,P27694,Q14683,Q15424,P07910,Q9UKX7 Phase 2 plateau phase -0.647249190938524 -2.5080689659008764 0.01213929715951112 0.9999999875087133 0.06280400266552628 1 Q99996 Phase 3 rapid repolarisation -0.647249190938524 -2.5080689659008764 0.01213929715951112 0.9999999875087133 0.06280400266552628 1 Q99996 Pou5f1 oct4 sox2 nanog repress genes related to differentiation -0.7254090990829205 -2.504508024657632 0.012262182362444918 0.9999999896221798 0.06322024816623852 2 Q92908,Q99626 Cristae formation 0.4005245518700776 2.491784353683097 0.012710318112832741 0.9999999947222187 0.06530473789007168 25 P06576,P38646,O75964,Q9Y512,P25705,Q13505,P56134,Q5XKP0,P36542,Q16891,P48047,O75431,Q9NVH1,Q9NX63,O75947,P24539 Beta oxidation of hexanoyl coa to butanoyl coa 0.7652156214153107 2.4900367708257893 0.012772987963590277 0.9999999951985278 0.06540120984793647 5 P30084,P55084,Q16836 Post translational protein modification 0.12463186435488878 2.482061098393937 0.01306248757849926 0.9999999968983845 0.0666544742875476 642 P06748,P62191,Q14204,Q99567,P46060,P25788,Q96FW1,P35998,Q9Y3E5,Q9UQE7,P54578,Q14694,O14818,P49792,P27824,P49790,Q92841,Q16531,P15880,P57740,Q15022,Q9Y6G9,P46459,P27797,P35658,P12004,P68036,Q92621,P51610,P61201,P22314,Q9NRG9,P21796,Q99436,Q15293,Q86UP2,Q7Z3B4,Q9BW27,P52948,Q15008,Q9BT78,P07237,P25786,P11388,O75150,O00487,P12270,P14625,P61163,P13639,O75340,Q92538,Q92905,Q86VP6,P18085,P60900,Q13200,P07910,P61289,O43242,P28074,P62333,P61106,P61081,Q8N1F7,Q12769,Q13617,Q15084,P45973,Q13616,O00231,Q99460,P63208,Q8TEM1,Q86UV5,Q7L5N1,Q9HCU5,O60763,Q9UL46,P48556,P78527,P49720,Q9Y277,Q16222,P04843,Q13724,P53621,P51149,Q9BUN8,P14314,O94979,Q9NYU2,O75832,Q8WVM8,Q14203,P35606,O15294,Q9UJW0,O60725,P54920,P54727,Q8N7H5,P10619,O43681,Q01082,O15498,Q6P1J9,O43505,P47756,P04844,Q9BTY2,Q9UNM6,Q07065,P53992,Q92890,P27694,P20618,P14735,Q92769,Q13561,A0AVT1,Q06323,P16278,P61086,Q9Y5K5,P17980,P39656,P26358,P45880,O60678,Q9Y678,Q9Y2X3,P49755,Q15436,P49721,Q9Y5A7,P62820,P55072,P51148,Q8WUM0,P09874,P53618,P28070,P78406,Q9BUF5,O94826,P62805,P30101,O75935,Q14789,Q9Y265,P52907,Q13813,Q12907,O60493,Q15370,P25789,Q02880,Q9BVK6,Q9UBF2,Q06210,P25787,Q9BTX1,P61026,Q13098,P63241,Q9Y3B3,P61978,P28066,Q9Y6Y8,Q93009,Q13330,Q99627,Q8N6T3,Q13618,O00232,P11142,Q9NP72,P51153,P51665,Q13620,O96019,P34949,Q9NR45,Q9NZL9,P17844,Q99497,P06493,O75396,P38117,Q8IXI2,Q13217,Q10471,Q5JRA6,Q8N3U4,Q93008,P04439,Q9UBE0,Q14318,Q02818,Q8NB78,O43852,Q96K76,Q14166,P46977,P43686,P11387,Q14697,P48444,Q9UBT2,P45974,Q14258,Q13263,P04637,O75694,Q14676,O60216,P62195,Q14683,Q15424,Q9UKX7 Mitochondrial protein import 0.3240268871610092 2.476076432206553 0.01328351376746828 0.999999997778466 0.06755097444890014 48 P06576,Q9Y512,O75439,Q13505,Q9NS69,P08574,Q9UJS0,P12236,Q10713,O75390,O94826,O96008,P12235,P21796,Q99798,Q9NX63,P38646,P25705,Q9HAV7,O43615,O75746,Q5JRX3,P10809,O75431 Pten regulation 0.2647960236427415 2.4630524114877534 0.013775977661090621 0.9999999989441324 0.06981702964294227 95 Q06323,Q9HCE1,O43242,P28074,P62191,P17980,O60341,P51665,P62333,P25788,P49721,P35998,O00231,Q99460,O14818,Q9UL46,P48556,P28070,P49720,Q14839,Q15022,Q6IAA8,Q86YP4,O75832,P25789,P43686,O94776,Q99436,P25787,Q15008,P42345,P25786,O00487,P04637,P28066,Q9UNM6,Q93009,P62195,P60900,P20618,Q92769,Q13200,P61289,O00232 Gene silencing by rna 0.2988804268243287 2.458186259958842 0.013964072921726967 0.9999999992053401 0.07043477899348399 60 Q99598,Q15631,P30876,P37198,Q8N1F7,Q12769,Q99567,P24928,P19387,Q8TEM1,P49792,Q8WUM0,P49790,Q9Y2W6,P78406,P62487,P62805,Q9HAV4,O15397,P57740,P62826,P35658,Q92621,Q9BQ52,Q5SRE5,Q9NRG9,P16104,P07900,Q7Z3B4,Q9BTX1,Q9BVL2,P52948,Q9BW27,P62875,P12270,O75694,Q96EE3,Q8NFH4,Q8NFH3,P19388,Q9UKX7 Diseases of signal transduction by growth factor receptors and second messengers 0.2132167842287939 2.4574581190864797 0.013992412471188764 0.9999999992386527 0.07043477899348399 211 P06748,P62191,P30876,P24928,P25788,P35579,P35998,O14818,P49792,Q6UN15,Q00610,Q9Y490,P28072,P62753,P51608,P46940,Q9P2E9,Q99436,P07900,P62993,Q15008,Q6WCQ1,Q16630,P25786,P35232,O00487,P12270,P30153,O43252,P60900,P48729,Q13200,P61289,P26038,O43242,P28074,P33176,P10644,P26641,P62333,Q53H12,Q14738,Q13616,O00231,Q99460,P63208,Q09161,P31946,Q9UL46,P48556,P49720,P28482,P02545,Q13363,O94979,O75832,Q16543,Q14203,P49589,P40763,O00203,Q9NRY5,P06753,Q01082,P42345,P41240,P31939,Q9UNM6,P20618,Q92769,Q06323,P30154,P17980,Q9NR09,Q96PU8,P63000,P49721,Q7KZF4,P55072,P51114,Q13573,P62140,P28070,Q14789,Q06124,P25789,P25787,P28066,P56545,O00232,P51665,P18206,Q07866,P62487,Q7Z2W4,O94905,P43686,P42224,P30086,P35222,P62195,Q92542 C type lectin receptors clrs 0.2796684147689908 2.4517575184055618 0.014216042383977667 0.9999999994569974 0.07131953923274992 77 Q06323,O43242,P28074,P62191,P17980,P51665,P62333,P61081,P25788,Q13616,P49721,P35998,O00231,P63208,Q99460,O14818,Q9UL46,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Pyrimidine catabolism -0.7141815024013466 -2.4451670679744173 0.014478505578864542 0.9999999996348342 0.07239252789432271 2 Q8TCD5 Lagging strand synthesis 0.40829126667950505 2.443276704418005 0.014554573262716364 0.9999999996745069 0.07252947880082737 22 P40938,P27694,P09884,P15927,P35251,P18858,P28340,P40937,Q9Y2S7,P12004,P35249,P49642,P39748,P35250,P49643 Signaling by wnt 0.24193188550924455 2.436552601936026 0.014828012644053867 0.9999999997847411 0.07364579613213422 125 Q06323,Q9HCE1,P30154,O43242,P28074,P62191,P17980,P51665,P62333,P53680,P48729,P25788,Q14738,Q13616,P49721,P35998,O00231,Q99460,P63208,P56545,O14818,Q9UL46,Q00610,P48556,P28070,P49720,P07737,Q9UBQ0,Q96CW1,P62805,P28072,Q9Y265,Q96QK1,Q13363,Q14160,O60493,O75832,P63104,P51532,P25789,P43686,Q99436,P25787,P67870,Q15008,P19784,Q6P1J9,P25786,P63010,Q15291,O00487,O14980,O94973,P35222,P28066,O75436,Q9UNM6,P62195,P30153,P60900,P20618,Q13618,Q13200,P61289,O00232 Apoptotic cleavage of cell adhesion proteins 0.6543594532213001 2.429794201166112 0.01510739832021013 0.9999999998589335 0.07478413121964483 7 P35222,Q14126,P15924 Lysine catabolism 0.6529207523118266 2.421871011377528 0.01544083022537901 0.9999999999148247 0.07618157958879049 7 P36957,Q92947,P09622,Q02218,P49419 Interferon signaling 0.2706917861117907 2.412437490832508 0.015846254417634542 0.99999999995389 0.07792382535404445 84 P18031,P52294,P21333,Q9Y3Z3,Q99567,P37198,Q8N1F7,Q12769,O00505,Q8TEM1,P38919,P49792,Q8WUM0,P49790,P78406,P61221,P10321,P04439,P55265,P57740,P19474,P60842,Q06124,P35658,Q92621,Q12899,Q5SRE5,Q9NRG9,P42224,Q7Z3B4,Q9BW27,Q9BVL2,P52948,P61088,Q04637,Q9Y4X5,Q9BTX1,O43432,O75369,Q14258,Q13555,P19525,O15344,Q8NFH5,P52292,P06730,P12270,P19174,O75694,Q96EE3,Q8NFH4,Q8NFH3,P29372,Q14240,Q6L8Q7,P78344,Q14974,Q9UKX7 Nr1h3 nr1h2 regulate gene expression linked to cholesterol transport and efflux -0.5695313238934222 -2.409788993493314 0.01596174907095227 0.9999999999612875 0.07802828251823286 13 Q9Y4C1,Q9UPQ9,Q09472,Q8NDV7,P02654,Q9UL18,O15379,P28702 Irf3 mediated induction of type i ifn 0.6719221530814654 2.4095494287828654 0.015972232327557734 0.9999999999618971 0.07802828251823286 6 P49959,P13010,P12956,P78527 Nr1h2 nr1h3 regulate gene expression to control bile acid homeostasis -0.7064182731432787 -2.4038926251955495 0.01622153713161678 0.9999999999738788 0.07898722328793792 2 P28702 Ptk6 regulates proteins involved in rna processing 0.7381058530294642 2.394239226665082 0.01665488195298037 0.9999999999864515 0.08075000184042087 3 Q07666 Cell cycle checkpoints 0.2092627050571924 2.3917002639428735 0.01677053199076317 0.9999999999886294 0.08075000184042087 207 P25205,O43242,Q92878,P62191,P28074,Q9Y266,O96028,P62333,P17980,P51665,Q14008,P46060,Q12769,P25788,Q14738,P49736,P62258,P35998,O00231,Q99460,P49721,P06493,P35249,Q15005,P31946,O14818,P49792,Q8WUM0,P49959,Q9UL46,P48556,P28070,P49720,P33991,Q04917,P62805,P57740,P27348,Q99661,Q9Y6G9,P30260,P35250,O75832,Q9P258,P63104,P25789,Q14566,P43686,P40937,Q99436,P25787,Q9BW27,P52948,Q15008,P33992,P25786,O00487,O14980,P04637,P33993,P28066,Q14676,Q9UNM6,Q15691,P62195,P30153,P27694,P60900,P20618,Q14204,Q13200,P61289,O43684,O00232 Resolution of ap sites via the multiple nucleotide patch replacement pathway 0.38464726780808073 2.391507073951303 0.016779360610763128 0.9999999999887806 0.08075000184042087 26 P40938,P18858,P27695,Q07864,Q86W56,P35249,Q9NX46,P49005,P09874,P35244,P15927,P28340,P39748,P35250,P12004,P40937,Q9Y2S7,Q9NR33,P41440,P35251,P27694 Synthesis of wybutosine at g37 of trna phe -0.7040100701312922 -2.391048444055207 0.016800335953376155 0.9999999999891316 0.08075000184042087 2 O60294,Q32P41 Cell cycle mitotic 0.1872675826180448 2.3875690043427653 0.016960218504548985 0.9999999999914704 0.08125635232082955 374 P62191,P53350,Q9NTJ3,Q14008,P46060,Q99567,P37198,P25788,Q9UJX2,P35998,Q9UQE7,O14818,P49792,P49643,P49790,Q99986,O95347,P33991,P43034,P28072,Q9NTI5,P57740,P62826,Q9BPX3,Q9Y6G9,Q99661,P30260,P35658,P12004,Q92621,Q9P258,Q14566,P08238,P14635,Q9NRG9,Q99436,P07900,Q7Z3B4,Q9BW27,Q9BSJ2,P52948,P11802,Q15008,Q9Y2S7,P19784,O00139,P33992,Q29RF7,P25786,P11388,O00487,O14980,P33993,P12270,P61163,P42166,Q15691,P30153,P60900,Q13200,P61289,Q15021,P40938,P25205,O43242,P28074,Q9Y266,P09884,P62333,Q8N1F7,Q12769,Q14738,Q13616,P20700,P62258,O00231,Q99460,P63208,Q8TEM1,Q15005,O60763,Q9UL46,P48556,P49720,P28482,P28340,Q9Y2U8,P02545,Q7Z5K2,P35250,O75832,P04183,Q14203,P40937,Q9UJX3,Q9H1A4,Q9ULW0,Q9UNM6,P27694,P20618,P49642,Q13561,O43684,Q92973,Q86XL3,Q06323,O94927,P30154,P17980,P07437,Q9BRT9,Q07864,P49721,P62820,Q14739,Q8WUM0,P62140,P28070,P78406,Q9BUF5,P62805,O75935,P50402,P31350,Q9HC35,Q9UJX4,P25789,P63151,P25787,Q9BRX5,Q9BTX1,Q9BVL2,P53990,P28066,P18754,O43264,Q96EE3,P49736,O00232,Q02241,O75531,Q8TD19,P51665,Q9H6D7,Q01105,P06493,P63167,P61006,P35249,Q9BVA1,Q15003,Q15154,P15927,Q8N3U4,Q2NKX8,Q13547,P00374,P42167,P39748,O95684,Q9Y570,Q6KC79,P61981,Q5SRE5,P43686,P04818,Q14980,P67870,O60566,Q7Z460,P35251,P04637,O75694,O60216,Q8NFH4,P62195,Q14974,Q14683,Q14204,Q9UKX7 Trail signaling -0.7018521848588591 -2.3795229890441907 0.01733506169115495 0.9999999999951679 0.08278603179429768 2 Q13158,Q14790 Tnf receptor superfamily tnfsf members mediating non canonical nf kb pathway -0.625314635023385 -2.3778217001862725 0.017415244532374974 0.9999999999957211 0.08281529114388853 1 Q12933 Golgi cisternae pericentriolar stack reorganization 0.551872544770938 2.3770367353295945 0.01745234994575906 0.9999999999959552 0.08281529114388853 12 Q08379,O60763,P53350,P28482,Q9H0U4,P61019,P14635,Q9H8Y8,P06493,P62820 Chondroitin sulfate biosynthesis -0.7496402877698197 -2.3721700593201254 0.017683949313700653 0.9999999999971533 0.08346815513449345 3 Q8N6G5,Q9NRB3,Q9P2E5 Lgi adam interactions 0.6156058971592884 2.371793707334185 0.01770197115604022 0.99999999999723 0.08346815513449345 1 Scavenging of heme from plasma -0.6236965120460387 -2.368134960193136 0.017878013015987015 0.9999999999978793 0.08403230092687904 1 Q07954 Hsp90 chaperone cycle for steroid hormone receptors shr in the presence of ligand 0.3321972968123113 2.363547779600198 0.018100892422820092 0.9999999999984878 0.08481235757862245 38 P11142,Q9NZ32,P25685,P63167,Q9BVA1,Q13885,O60884,O43237,Q9BUF5,P68371,O75935,Q02790,Q9Y6G9,P52907,Q96FJ2,P31948,Q14203,P31689,P08238,P07900,P54652,Q9UJW0,Q13409,P47755,P47756,P0DMV9,Q13451,Q15185,P61163,Q14204,Q13561 Copi dependent golgi to er retrograde traffic 0.2848238048655551 2.3556479595740583 0.0184904317109309 0.9999999999991628 0.08574277565305106 65 Q9P2W9,P33176,Q14807,Q9Y678,P49755,O75396,Q9BVA1,P62820,Q9H0H5,Q13885,Q07866,P53618,Q12981,Q9BUF5,Q15363,P68371,P53621,Q99747,Q99661,O14579,P46459,Q6NUQ1,P35606,Q9BW19,P24390,Q9BVK6,O95235,P61923,Q9UBF2,O95239,P52732,P54920,P48444,O00139,O15260,Q9Y3B3,Q9H0U4,O43264,Q92538,Q8N6T3,P18085,Q02241 Olfactory signaling pathway -0.6973565905412902 -2.355461962645954 0.01849969092549264 0.9999999999991744 0.08574277565305106 2 O60266,P62873 Sumo is transferred from e1 to e2 ube2i ubc9 0.7301088878993278 2.3548607733209415 0.018529646818981504 0.9999999999992111 0.08574277565305106 3 Q9UBE0 Sumo is conjugated to e1 uba2 sae1 0.7301088878993278 2.3548607733209415 0.018529646818981504 0.9999999999992111 0.08574277565305106 3 Q9UBE0 Phospholipase c mediated cascade fgfr2 0.6121898597626685 2.351556444432455 0.018695052975757465 0.9999999999993863 0.08597416337616859 1 Phospholipase c mediated cascade fgfr4 0.6121898597626685 2.351556444432455 0.018695052975757465 0.9999999999993863 0.08597416337616859 1 Deubiquitination 0.23079036386196528 2.3407659410164614 0.01924422736623055 0.9999999999997335 0.08822738084825699 141 Q06323,Q9Y5K5,O43242,P28074,P62191,P17980,P51665,O96019,P62333,P45880,Q9NZL9,P25788,P06493,Q96FW1,P49721,P35998,O00231,Q9Y3E5,Q99460,P55072,P54578,Q86UV5,Q14694,O14818,Q8IXI2,Q9UL46,P48556,P28070,P49720,Q9Y277,O94826,Q93008,Q9Y265,Q14318,Q8NB78,O60493,P51610,O75832,P25789,P21796,P43686,Q99436,O15294,P25787,Q15008,P54727,P45974,P25786,Q14258,O00487,P04637,P28066,Q9UNM6,Q93009,Q92890,P62195,P60900,P20618,P14735,Q13200,P61289,O00232 Translesion synthesis by y family dna polymerases bypasses lesions on dna template 0.378590137771966 2.3375429545724984 0.01941097016419091 0.9999999999997932 0.08871885136394005 26 P40938,P27694,Q14258,P35251,P28340,P40937,Q07864,Q92890,P35250,P35249,P55072,Q9Y2S7,Q14694,Q8TAT6,P12004 Signaling by notch1 hd domain mutants in cancer -0.693040819996424 -2.3323001924938733 0.019684904416177762 0.9999999999998636 0.08969574183518307 2 Q86YT6,P78536 Zinc transporters -0.6775236035380084 -2.326036432035739 0.020016607208368953 0.9999999999999176 0.09065271957589587 6 Q92504,Q9ULF5,Q6NXT4 Metal ion slc transporters -0.6775236035380084 -2.326036432035739 0.020016607208368953 0.9999999999999176 0.09065271957589587 6 Q92504,Q9ULF5,Q6NXT4 Base excision repair 0.32980790166493623 2.3212995775412875 0.020270681026614668 0.999999999999944 0.09151383201883462 37 P40938,P18858,P27695,Q07864,Q9NYB0,Q86W56,P35249,Q9NX46,P49005,P09874,P35244,P15927,P28340,P62805,P39748,P35250,P12004,P18887,P16104,P40937,P41440,Q9Y2S7,Q9NR33,P35251,P49916,P29372,P27694 Sumoylation of chromatin organization proteins 0.3078456920284736 2.3202088364141087 0.020329582817606884 0.9999999999999488 0.09151383201883462 49 Q99567,Q8N1F7,Q12769,P45973,Q8TEM1,P49792,Q8WUM0,P49790,P78406,P62805,P57740,Q15022,P35658,Q92621,Q5SRE5,Q9NRG9,Q7Z3B4,Q9BTX1,Q9BW27,P52948,P12270,O75694,Q8NFH4,Q92769,Q9UKX7 Activation of the ap 1 family of transcription factors -0.6761552153721241 -2.3184403370280844 0.02042540197236109 0.9999999999999557 0.09157069615333989 6 P45984,P05412,P45983 Defects in biotin btn metabolism 0.6341091921283378 2.3177092359224094 0.020465128737625626 0.9999999999999584 0.09157069615333989 7 P11498,Q13085,Q96RQ3,P05165,Q9HCC0 Innate immune system 0.1663904699641191 2.3149210549793495 0.020617252863511126 0.9999999999999669 0.09197516995997479 440 P06744,P62191,P25788,P35579,P35998,Q96JM3,O00571,O14818,Q01518,P60953,P49959,P51452,P53396,P04080,P30041,P18669,Q9Y2A7,P14618,Q15366,P46940,Q9Y6G9,P38606,P50570,Q12905,Q9UQ80,P00387,P08238,P11279,Q99436,P07900,P62993,O60610,Q15008,P25786,O00487,P14625,P13639,P30153,Q86VP6,P60900,Q13200,P61289,O43242,P28074,P62333,P61106,P61081,Q92820,Q14738,Q13616,Q9UI12,O00231,Q99460,P63208,Q9UJV9,Q9UL46,P48556,Q13162,P78527,P49720,Q5T4S7,Q8NF37,P51149,P07686,P14923,P14174,P14314,P31949,P17858,O75832,P12956,P50395,P10619,Q9Y487,O43681,P06280,Q96CS3,P10253,Q9BTY2,Q9UNM6,Q07065,Q9UQB8,P00491,P15586,P20618,Q14019,Q06323,P16278,Q8IV08,P61086,P17980,P21283,P42785,P39656,P07437,P07355,P09601,P30519,Q8NBS9,P49721,Q93050,P55072,P51148,P11216,P53618,P28070,O75131,O94826,O15145,Q7L576,Q96G03,Q13177,P50990,P52907,Q13813,Q6IAA8,P21281,P25789,Q9H2U1,P09429,O75874,P25787,P07384,P61026,O00264,O00159,O94973,Q9Y2Z0,P11717,Q9P0L0,P28066,Q13510,P09960,Q7Z6Z7,P09972,P61158,O00232,P51812,P11142,P06737,Q9NP72,P51665,P61160,P18206,P36871,P23528,Q13217,Q9NZJ7,P78371,P10321,P07741,P04075,Q08211,P43686,P59998,P15924,O14802,P37108,Q99536,Q14258,P35222,P13010,P0DMV9,Q9NZI8,P12268,P62195,Q14974,Q14204 Death receptor signalling -0.32928449254977965 -2.306425604762367 0.021086862649842608 0.9999999999999838 0.09378932939780742 56 Q8WXG6,P19838,P78536,Q6ZSZ5,Q9Y5V3,Q13107,Q7Z628,P52735,Q9NZN5,Q96EP0,O15085,Q9Y6K9,Q8N5V2,Q12979,Q14790,P98170,O15013,O75962,P41743,P45983,Q86VP1,P49768,O15379,P51617,Q13158 Cell cycle 0.1619818332021303 2.2985278070746498 0.021531767109501887 0.9999999999999918 0.09548313390820777 454 P06748,P62191,P53350,P30876,Q9NTJ3,Q14008,P46060,Q99567,P24928,P25788,Q9UJX2,Q5H9R7,P37198,P35998,Q9UQE7,O00743,O14818,P49792,P49643,P49959,P49790,Q99986,O95347,P33991,Q13309,P43034,O60832,P28072,Q9NTI5,P57740,P62826,Q9BPX3,Q9Y6G9,Q99661,P30260,P35658,P12004,Q92621,Q16763,Q9P258,Q14566,P08238,P14635,Q9NRG9,P16104,Q99436,P07900,Q7Z3B4,Q9BW27,Q13409,P52948,Q9BSJ2,P11802,Q15008,Q9Y2S7,Q9NY12,P19784,O00139,P33992,Q29RF7,P25786,P11388,O00487,O14980,P33993,P12270,Q9UH99,P61163,P42166,Q15691,Q8NFH3,P30153,P60900,Q96CW5,P19388,Q13200,P61289,Q15021,P40938,P25205,O43242,P28074,Q92878,Q9Y266,P09884,P18858,P62333,Q8N1F7,Q12769,Q14738,Q13616,P20700,P62258,Q8WUX9,P19387,Q99460,Q8TEM1,O00231,P63208,P31946,Q15005,O60763,Q9UL46,P48556,P49720,Q96DE5,P28482,P28340,Q04917,Q9H8Y8,Q9Y2U8,P02545,P27348,Q9NX24,Q7Z5K2,P24941,P35250,O75832,P04183,O60264,Q14203,P55036,P40937,O60934,O95235,P54652,Q12888,Q9UJX3,Q96T23,P61088,P41440,Q9BTC0,P62875,Q9H0U4,Q9H1A4,Q9ULW0,Q9UNM6,P27694,P20618,P49642,O96028,Q13561,O43684,Q92973,Q08379,Q86XL3,Q06323,P17612,P17980,O94927,P30154,Q8WXH0,P07437,Q9BRT9,Q07864,Q9NYB0,P49721,Q9UQ84,P62820,Q14739,Q13885,Q8WUM0,Q00534,P50748,P62140,P28070,Q14997,P78406,P68371,Q9BUF5,P61019,P62805,O75935,Q9NWV8,P50402,Q9Y265,P31350,Q8NC56,Q9HC35,Q96FJ2,Q9UJX4,P25789,Q53HL2,P63151,P25787,Q9BRX5,Q9BTX1,Q9BVL2,P53990,Q9NR33,Q9NXR7,Q8NFH5,P28066,P18754,Q9UBD5,O43264,Q96EE3,P49736,O00232,Q8TD19,O75531,Q02241,Q9Y230,P51665,Q9H6D7,Q01105,P06493,P63167,P61006,P35249,Q9BVA1,Q15003,Q15154,P15927,P62487,Q8N3U4,Q2NKX8,Q13547,P00374,P42167,P39748,O95684,P63104,Q9Y570,Q6KC79,P61981,Q5SRE5,P43686,P04818,Q14980,P67870,O60566,O94901,Q7Z460,P35251,P04637,O75694,Q14676,Q9Y619,O60216,Q8NFH4,P62195,Q14974,Q14683,Q14204,Q9UKX7 Mitotic telophase cytokinesis 0.5238754063440468 2.2920363166809943 0.021903547636085152 0.9999999999999953 0.09676115285047757 13 Q29RF7,Q6KC79,P53350,Q8N3U4,O60216,Q9NTI5,Q9UQE7,Q7Z5K2,Q14683,Q02241 Wnt5a dependent internalization of fzd2 fzd5 and ror2 0.6087915880765765 2.2912346589393158 0.02194984541171907 0.9999999999999957 0.09676115285047757 8 Q00610,P63010,O95782,O94973,P53680,Q96CW1 Nef mediated cd4 down regulation 0.6485513766420754 2.2835483995800074 0.022398085309892846 0.9999999999999978 0.09815631503453041 6 P63010,O94973,P53680,Q96CW1,Q9UI12 Nef mediated cd8 down regulation 0.6485513766420754 2.2835483995800074 0.022398085309892846 0.9999999999999978 0.09815631503453041 6 P63010,O94973,P53680,Q96CW1,Q9UI12 Electric transmission across gap junctions -0.6836899838158805 -2.2819038553317843 0.022495017184434474 0.9999999999999981 0.0982920105712826 2 Q96RD7,P36383 Interleukin 17 signaling -0.36172479740890706 -2.2636469242371753 0.023595839328709012 0.9999999999999997 0.10137659697709091 36 Q9UKB1,P19838,O14733,Q13164,Q16644,P49137,P45984,P05412,P45983,Q9Y297,Q13404,Q9Y6K9,P45985,P52564,P18846,P16220,P51617,P46734 Fc epsilon receptor fceri signaling 0.26331729996512504 2.262668343394611 0.0236561416727743 0.9999999999999997 0.10137659697709091 78 O43242,P28074,P62191,P17980,P51665,P62333,P25788,Q13616,P49721,P35998,O00231,Q99460,P63208,O14818,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,P62993,Q15008,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Pd 1 signaling 0.6676856680453095 2.2623268190327126 0.02367721862283667 0.9999999999999997 0.10137659697709091 2 P41240 Pi 3k cascade fgfr3 0.6676856680453083 2.262326819032702 0.023677218622837337 0.9999999999999997 0.10137659697709091 2 P62993 Pi 3k cascade fgfr2 0.6676856680453083 2.262326819032702 0.023677218622837337 0.9999999999999997 0.10137659697709091 2 P62993 Pi 3k cascade fgfr4 0.6676856680453083 2.262326819032702 0.023677218622837337 0.9999999999999997 0.10137659697709091 2 P62993 Pi 3k cascade fgfr1 0.6676856680453083 2.262326819032702 0.023677218622837337 0.9999999999999997 0.10137659697709091 2 P62993 Glycosphingolipid metabolism 0.39989863958882604 2.2474765635547143 0.024609586736188405 0.9999999999999999 0.10497606590448881 21 Q9NXE4,P16278,Q9BSJ8,A0FGR8,P06280,P07602,Q9NZJ7,P10619,Q13510,P07686,P04062,P06865,O43681 Mitochondrial trna aminoacylation 0.38514579712759034 2.245255311186597 0.024751747131197988 0.9999999999999999 0.10497606590448881 22 P47897,Q5JTZ9,Q6PI48,Q9NSE4,Q9BW92,Q9H2U2,Q9NP81,P41250,P26640,Q9Y2Z4,Q15046 Runx1 and foxp3 control the development of regulatory t lymphocytes tregs -0.6026609133405366 -2.2412255157674994 0.025011470861017848 1.0 0.10497606590448881 1 Q13951 Runx1 regulates transcription of genes involved in wnt signaling -0.6026609133405366 -2.2412255157674994 0.025011470861017848 1.0 0.10497606590448881 1 Q13951 Runx1 regulates transcription of genes involved in interleukin signaling -0.6026609133405366 -2.2412255157674994 0.025011470861017848 1.0 0.10497606590448881 1 Q13951 Runx2 regulates chondrocyte maturation -0.6026609133405366 -2.2412255157674994 0.025011470861017848 1.0 0.10497606590448881 1 Q13951 Runx3 regulates immune response and cell migration -0.6026609133405366 -2.2412255157674994 0.025011470861017848 1.0 0.10497606590448881 1 Q13951 Mapk family signaling cascades 0.225716569235619 2.2401447085215827 0.025081529840267125 1.0 0.10497606590448881 132 Q96P70,Q06323,Q9HCE1,O43242,P28074,P62191,P17980,P51665,P62333,P18206,P25788,Q14738,P06493,P25685,P35998,O00231,Q99460,P49721,P31946,O14818,P60953,Q9UL46,P48556,P28070,P49720,Q9Y490,P46940,Q13813,O75608,O75832,P25789,P43686,Q99436,P30086,P25787,P62993,O60725,Q15008,Q01082,P25786,P35232,O00487,P41240,O14980,P53041,P28066,Q9UNM6,Q9NZI8,P62195,P30153,P60900,P20618,Q13618,Q13200,P61289,O00232 Pcna dependent long patch base excision repair 0.3840604356900446 2.235903265602454 0.025358108363415788 1.0 0.10583636263722555 22 P40938,P27694,P35251,P15927,P18858,P28340,P40937,Q9Y2S7,P27695,Q07864,P41440,P35249,P39748,P35250,P12004 Synthesis of bile acids and bile salts via 24 hydroxycholesterol -0.601402373247045 -2.2335748644993934 0.025511059315333373 1.0 0.10617731391018638 1 O14975 Defective chst14 causes eds musculocontractural type 0.5920532182668032 2.2314019173915454 0.025654517968530577 1.0 0.10647696872732747 1 Rrna modification in the mitochondrion -0.6580670547822277 -2.2173822348438414 0.02659698264702648 1.0 0.10994005580290346 6 Q6IN84,Q7Z6M4,Q9UI43 Gap filling dna repair synthesis and ligation in gg ner 0.3818185048442018 2.2165684534813863 0.02665259529464281 1.0 0.10994005580290346 22 P40938,P27694,P35251,P15927,P18858,P28340,P18887,P40937,Q9Y2S7,P49916,Q07864,P35249,P41440,P35250,P12004 Trp channels -0.6714920662239414 -2.215726066217947 0.026710268591040975 1.0 0.10994005580290346 2 Q8TEL6 G alpha q signalling events -0.3822639409193168 -2.214122073848675 0.026820382545496457 1.0 0.11008917353385599 30 Q14571,P52429,Q13164,P50148,P01111,P62879,Q9HAV0,Q3ZCW2,P25098,Q01970,P00533,P16220 Pexophagy -0.7296992810692846 -2.212416722616527 0.02693788447737311 1.0 0.11026771393210422 5 Q70CQ3,Q14596 Negative regulation of flt3 0.6580020869880087 2.210567001593684 0.027065835964105833 1.0 0.11048793311374709 2 Hcmv late events 0.29586013248230414 2.2078579593285435 0.02725417625522697 1.0 0.11095279404450324 50 Q99567,Q8N1F7,Q12769,Q8TEM1,P49792,Q8WUM0,P49790,P78406,P62805,P57740,P35658,Q92621,Q5SRE5,Q9NRG9,Q99816,Q9BTX1,Q7Z3B4,P52948,Q9BW27,P61978,P12270,O75694,Q8NFH4,Q9UKX7 Cd209 dc sign signaling -0.5260606469842819 -2.205119151456503 0.02744573451777743 1.0 0.11142818646182118 14 P19838,P04049,Q92793,Q09472,P06241,P01111,P22694 P75 ntr receptor mediated signalling -0.35481906920563366 -2.202107925583377 0.02765768577558614 1.0 0.11198356468919388 37 Q9NZN5,P19838,P45983,O15379,O15085,Q8N5V2,O15013,Q6ZSZ5,P49768,P41743,Q12979,Q7Z628,P52735 Class i mhc mediated antigen processing presentation 0.2083024166294929 2.1984808092057015 0.02791486065719795 1.0 0.11271854303312993 176 P62191,P25788,Q93034,P35998,O95486,O14818,P27824,P28072,P30260,P51572,P27797,P68036,P22314,Q9NZ08,Q99436,Q8TBC4,P29144,Q15008,P25786,O00487,O94874,Q9C0C9,P60900,Q13200,P61289,O43242,P28074,P62333,P61081,Q13617,Q13616,O00231,Q99460,P63208,Q9UL46,P48556,Q5T4S7,P49720,O94979,O75832,Q9UJX3,Q92990,P55786,P52888,Q9UNM6,P53992,P20618,A0AVT1,Q06323,P61086,P17980,Q15436,P49721,P28070,P30101,Q15370,Q9UJX4,P25789,P09429,P25787,P28066,Q7Z6Z7,Q13618,O00232,P60468,P51665,Q9ULT8,O75396,Q13867,P10321,P04439,Q9UIQ6,P43686,P61619,Q14669,P62195,Q9UJX2 Erythropoietin activates phosphoinositide 3 kinase pi3k -0.5949298813376598 -2.194125854608868 0.028226363034454582 1.0 0.11336194318419765 1 P07948 Cd22 mediated bcr regulation -0.5949298813376598 -2.194125854608868 0.028226363034454582 1.0 0.11336194318419765 1 P07948 Hats acetylate histones -0.32879898476562186 -2.192811879157677 0.02832093571100147 1.0 0.11343600593922631 53 Q9P2N6,Q9ULD4,O75528,O75529,Q68DK7,Q0PNE2,Q9HAF1,O75486,Q9NV56,Q9NPA8,P55201,Q01658,Q8NEM7,Q9H0E9,Q8IYH5,Q92794,Q12962,Q92993,Q96EZ8,Q9NS73,Q8N257,Q8WYH8,Q92793,Q09472,Q9UPT9,Q92830 Beta oxidation of butanoyl coa to acetyl coa 0.7392202399629271 2.188929668937682 0.028601952263728414 1.0 0.11425444738057731 4 P30084,Q16836 Rho gtpases activate rhotekin and rhophilins -0.7132760749518031 -2.187870665479278 0.028679024629045147 1.0 0.11425600721197131 3 P08134,Q9BST9 Hdr through mmej alt nhej 0.590001771516795 2.1827407899490456 0.029054904236867962 1.0 0.11544481950115536 8 P49959,Q92878,O60934,P49916,P39748,P09874 Cohesin loading onto chromatin 0.5491055964051447 2.1763130463981364 0.029531860664691045 1.0 0.11679665027312175 10 Q29RF7,Q8N3U4,O60216,Q9NTI5,Q9UQE7,Q7Z5K2,Q14683 Signaling by hedgehog 0.2489587465786293 2.175501179197567 0.029592579845933553 1.0 0.11679665027312175 87 P13861,O43242,P28074,P62191,P17980,P51665,P62333,P10644,P25788,Q13616,P49721,P35998,O00231,Q99460,P63208,P55072,O14818,P48556,P28070,P49720,O75832,P25789,P43686,Q99436,P25787,Q15008,P07237,Q6P1J9,P25786,O00487,P28066,Q9UNM6,P62195,P60900,P20618,Q13618,Q13200,P61289,O00232 Deposition of new cenpa containing nucleosomes at the centromere -0.40525739473365435 -2.1749976679502723 0.029630291143114107 1.0 0.11679665027312175 23 Q9BU64,Q8N257,Q8N0S6,Q7L2Z9,Q8NG31,Q6P0N0,O43482,Q03188,Q9NSP4,Q96BT3 Glycosaminoglycan metabolism -0.3661251719813913 -2.172971407072891 0.029782469364240116 1.0 0.11693762077655592 33 Q9Y251,Q9UL01,O94923,Q9P2E5,O60512,Q9Y274,Q8N6G5,Q11206,P51688,Q9NY97,O94766,Q9H1B5,Q9Y2C2,Q9NRB3,P34059,P15291,Q99653 Regulation of gene expression by hypoxia inducible factor -0.7101659517522808 -2.1719263263774424 0.029861220378672115 1.0 0.11693762077655592 3 Q92793,Q09472 Sumoylation of dna damage response and repair proteins 0.2700046607835974 2.1713927166175773 0.029901499003938126 1.0 0.11693762077655592 64 Q99567,P37198,Q12769,Q8N1F7,Q9UQE7,Q8TEM1,P49792,Q8WUM0,P09874,P49790,P78406,Q8N3U4,P57740,P35658,Q92621,Q5SRE5,Q9NRG9,Q7Z3B4,Q9BW27,Q9BTX1,P52948,P12270,O75694,Q14676,O60216,Q8NFH4,P27694,Q14683,Q9UKX7 Toll like receptor cascades -0.3151082774935542 -2.1698900485816788 0.03001517638984441 1.0 0.11707490267242977 61 Q9UKB1,P19838,P07711,P04114,Q8NEB9,P45984,P05412,Q9Y297,Q9Y6K9,P16220,Q14790,O14733,P49137,Q13404,P45985,Q00653,P46734,Q05193,Q13164,Q16644,P45983,O60443,Q13158,P52564,P18846,Q9H1C4,P51617,P16885 Apobec3g mediated resistance to hiv 1 infection 0.6917266187050211 2.16370238187641 0.030487198095740187 1.0 0.11860554872755322 3 O75531,O75475 Regulation of beta cell development -0.5734945127671437 -2.160652890206731 0.030722162538775244 1.0 0.11920839110097685 10 P26367,Q92793,Q09472,Q9Y243,Q92830 Rhog gtpase cycle 0.2926402779931936 2.1568110622973267 0.03102038883332936 1.0 0.12005293340691102 49 Q86XL3,P34897,P52565,O95292,Q14739,P61604,Q14126,Q13112,P60953,Q9BSJ8,Q7L576,P51149,P50402,Q13177,P42167,O95202,P05556,O75489,Q86UP2,O15498,P02786,P42166 Inhibition of replication initiation of damaged dna by rb1 e2f1 0.6044556813229389 2.1514564683290143 0.031440188248342604 1.0 0.12136238468919813 7 P49642,P30153,P49643,P09884 Chylomicron clearance -0.7052579144751788 -2.1467066540360555 0.03181664270340612 1.0 0.12249818508546542 3 Q5SW96,P04114 Met receptor activation 0.5767709457029769 2.139247257758458 0.0324156487072651 1.0 0.1244827746748067 1 Na cl dependent neurotransmitter transporters -0.5845019777058724 -2.130208141265165 0.033154433228567814 1.0 0.12699255915312607 1 Q9H2J7 Smad2 smad3 smad4 heterotrimer regulates transcription -0.5270121123200041 -2.115575099669645 0.03438096147128511 1.0 0.13129955667387727 13 O00255,P08047,O60563,Q13485,P28749,P24863,P49336,P01106 Copi mediated anterograde transport 0.25584490847748576 2.1147047583880747 0.034455118563413434 1.0 0.13129955667387727 73 Q08379,Q9NZ32,Q9Y678,P49755,P63167,Q9BVA1,P62820,Q13885,O60763,O43237,P53618,Q9BUF5,P68371,Q15363,P53621,O75935,Q14789,Q12955,Q99747,O14579,Q9Y6G9,Q13813,P46459,P52907,Q96FJ2,Q14203,P35606,P24390,Q9BVK6,P61923,Q9UBF2,Q9UJW0,P04350,Q13409,P48444,P54920,O15498,Q01082,Q9Y3B3,P47755,P47756,Q9H0U4,P61163,Q13190,Q92538,Q8N6T3,P18085,Q14204,Q13561 Plasma lipoprotein assembly -0.6025655511451006 -2.110315992855678 0.03483114695474887 1.0 0.13239390041473423 8 P02656,P02654,P04114,P22694 Fructose catabolism -0.5807263574253977 -2.1069561818790747 0.035121377963642786 1.0 0.1331573871904014 1 Q3LXA3 Ubiquinol biosynthesis -0.6367714246777915 -2.0968546782400885 0.03600644158232802 1.0 0.13616649227834707 6 Q9Y2Z9,Q5HYK3,Q9NZJ6,Q5T2R2,O75208 Synthesis of ip2 ip and ins in the cytosol -0.6180698104512432 -2.0937647185967645 0.036280944513569224 1.0 0.13685723373472947 7 P49441,O43426,Q14642 Pp2a mediated dephosphorylation of key metabolic factors 0.6775179856115082 2.0920613074218415 0.0364330318152406 1.0 0.13690015127364477 3 Q14738,P30153 Dap12 signaling -0.5628431038082139 -2.0915802523242992 0.036476080574253 1.0 0.13690015127364477 10 P13747,P06241,P01111,P52735,P16885,P29353 Dermatan sulfate biosynthesis -0.6943335753703442 -2.0903175456406515 0.036589284186986815 1.0 0.13697998351409635 3 Q9UL01,Q9Y2C2 Heme degradation 0.6823696972125337 2.0855334835976103 0.037020902057646854 1.0 0.1382484813681549 5 P30519,P09601 Mastl facilitates mitotic progression 0.6111119468947741 2.078619215409236 0.03765236340796241 1.0 0.14023419809377255 6 P14635,P06493,P30153 Activation of nima kinases nek9 nek6 nek7 0.6807867103996957 2.077657875454586 0.037740881500404555 1.0 0.14023419809377255 5 Q8TD19,P06493,P53350 Presynaptic function of kainate receptors -0.632480444661246 -2.0723660743650703 0.03823131470616126 1.0 0.141703131622339 6 Q9HAV0,Q01970,P62873,P62879 N glycan antennae elongation -0.7353840618816977 -2.066956439112513 0.03873825880601833 1.0 0.1432258203994226 4 P15291,Q11206,O60512,Q09328 Ca dependent events -0.46609555793847807 -2.0657767803715688 0.03884956154055774 1.0 0.14328179875106692 17 Q96RR4,P31323,Q16566,P25098,P16220,P31321,P22694,O60266 Rap1 signalling -0.5938939512862883 -2.0575342991214947 0.039634859150107005 1.0 0.14581713613249245 8 P04049,Q13976,Q96FS4,P22694 Protein localization 0.2207872399836311 2.0533977311716014 0.040034019175373636 1.0 0.14656824583547487 111 P06576,Q9Y512,O75439,O75521,Q13505,Q13011,Q9NS69,P09601,P08574,Q9UJS0,P12236,P28288,O00116,Q10713,O75390,O43808,O94826,Q93008,P50402,Q9Y2Q3,O96008,P21796,Q8NBU5,P12235,Q15067,O75874,Q9NX63,Q99798,O43765,P51659,O43681,P38646,P25705,P22307,Q9HAV7,O43615,O75746,Q5JRX3,P10809,P46379,O75431,P51648,P14735 Signaling by notch2 -0.6112228741776403 -2.053379811414964 0.040035755741636425 1.0 0.14656824583547487 7 Q86YT6,Q09472,P49768,P16220 Transcriptional regulation by runx1 0.22810685326462873 2.0482016536082788 0.04054024449697424 1.0 0.14805138308944024 99 Q06323,Q99873,Q9HCE1,O43242,P28074,P62191,P17980,P51665,O96019,P62333,Q86U86,P25788,P49721,P35998,O00231,Q99460,O14818,Q9UL46,P48556,P28070,P49720,Q8TAQ2,P62805,Q92922,P28072,Q07157,O75832,P51532,P25789,P43686,Q99436,P25787,P67870,Q15008,P19784,P25786,P61964,O00487,O14497,P28066,Q9UNM6,P62195,P60900,P20618,Q13200,P61289,O00232 Signaling by mapk mutants 0.6275849667325945 2.046322530333462 0.04072464843820178 1.0 0.14836118868684756 2 P28482 Transport of small molecules 0.17987379808498025 2.0384411268713176 0.041505836845839195 1.0 0.150547798647604 234 P54709,P62191,P25788,P30626,P35611,P05198,P35998,O14818,P28288,Q00610,Q10713,O75027,Q96TA2,P38606,P20042,Q8NE71,P21796,Q99436,Q15008,P07237,P02786,P25786,P35232,O00487,P05023,Q9UJZ1,Q86VP6,P60900,Q13200,P61289,O43242,P28074,P62333,P10644,Q13616,O00231,Q9UI12,Q99460,P63208,P16615,P12236,Q9UL46,P48556,Q12797,Q99623,P49720,Q9Y277,Q96CW1,Q9BUN8,P05141,P08195,O75832,Q9Y4W6,P12235,Q9Y487,P63010,Q9UNM6,P20618,Q9UBX3,Q06323,P17980,P36404,P21283,Q9HD20,P45880,P09601,P30519,P49721,Q93050,P55072,Q8TB61,P28070,Q15904,O95202,P21281,P25789,P25787,P35613,Q6P1M0,P28066,O76003,O00232,P13861,O75439,P51665,P43686,Q00341,P62195 Reduction of cytosolic ca levels 0.7073750673368839 2.0382299349251265 0.041526943116889425 1.0 0.150547798647604 4 P30626,P16615 Nr1h2 and nr1h3 mediated signaling -0.4886555983275165 -2.0290364675433574 0.042454576074804296 1.0 0.15319383901098874 15 Q9Y4C1,Q9UPQ9,Q09472,Q8NDV7,P02654,Q9UL18,O15379,P28702 Fgfr2 alternative splicing 0.3738296273541288 2.0289591291007785 0.04246245336344856 1.0 0.15319383901098874 21 P26599,P52272,Q01085,P62487,P30876,P24928,P52597,P31943,P09651 Sting mediated induction of host immune responses 0.5809764631414348 2.018152522056799 0.04357537907845144 1.0 0.15593937791986898 7 P49959,P13010,P12956,P78527 Synthesis of pyrophosphates in the cytosol -0.691390388117131 -2.016725543186332 0.04372416278137936 1.0 0.15593937791986898 5 O95989,Q92551,O43314 Neurofascin interactions 0.5566343042071117 2.0165936497135735 0.043737936264873545 1.0 0.15593937791986898 1 Telomere maintenance 0.26383275081972346 2.0162483252447982 0.043774015457854976 1.0 0.15593937791986898 56 P40938,P09884,Q9Y230,P18858,P30876,P24928,Q5H9R7,P35249,P19387,O00743,P49643,P15927,P62487,P28340,P62805,O60832,Q9Y265,Q9NX24,P24941,P39748,P35250,P12004,P16104,P40937,Q9NY12,P41440,Q9Y2S7,P62875,P35251,P27694,P49642,P19388 G protein mediated events -0.38154317678459215 -2.016082043225477 0.043791397417810796 1.0 0.15593937791986898 25 Q14571,Q96RR4,P50148,Q16566,P31323,P25098,Q01970,P16220,P31321,P22694,O60266 Collagen biosynthesis and modifying enzymes 0.49598237983769355 2.015508379506512 0.043851408958674565 1.0 0.15593937791986898 12 O60568,P07237,P23284,Q02809,O75718,P13674,O00469,Q8NBJ5,Q32P28,P50454 Fatty acids bound to gpr40 ffar1 regulate insulin secretion -0.6796779367456581 -2.0141186020494137 0.043997082937458076 1.0 0.15608488946860127 3 Q01970,P50148 Depolymerisation of the nuclear lamina 0.5088099587683451 2.0103627407697564 0.04439281092945513 1.0 0.15711469901398606 11 P14635,P42166,P02545,P20700,P06493,P50402,P42167 Biosynthesis of the n glycan precursor dolichol lipid linked oligosaccharide llo and transfer to a nascent protein -0.32980186620859314 -2.009276117583652 0.04450785921333167 1.0 0.15714860243569712 43 A2VDF0,Q9UPQ8,O14772,Q9BVK2,Q9Y274,O15305,Q11206,Q96E22,O94808,Q9H6U8,Q96F25,Q9NP73,Q9Y672,Q8TBE9 Transport of bile salts and organic acids metal ions and amine compounds -0.523500982642862 -1.999798580963637 0.04552201789448129 1.0 0.16034774589447748 12 Q9ULF5,Q8IWA5,Q92504,Q6PCB8,Q6NXT4 Diseases of base excision repair -0.563286587558443 -1.9988077658773078 0.04562915722097882 1.0 0.16034774589447748 1 P78549 Antigen processing ubiquitination proteasome degradation 0.204750141236053 1.9929840653779152 0.04626319197747564 1.0 0.16128061213637654 140 Q06323,P61086,O43242,P28074,P62191,P17980,P51665,P62333,P61081,Q13617,P25788,Q13616,P49721,P35998,O00231,Q99460,P63208,A0AVT1,O14818,Q9UL46,P48556,Q5T4S7,P28070,P49720,Q13867,P30260,P68036,Q15370,O75832,P22314,P25789,P43686,Q99436,P29144,P25787,Q9UJX3,Q15008,Q14669,Q92990,P25786,P55786,P52888,O00487,P28066,Q9UNM6,O94874,P62195,Q7Z6Z7,Q9C0C9,P60900,P20618,Q13618,Q13200,P61289,O00232 N glycan antennae elongation in the medial trans golgi -0.5833421941392839 -1.9928750076210786 0.04627513565667596 1.0 0.16128061213637654 8 O60512,Q11206,Q9BYC5,Q09328,P15291,Q10469 Transcription coupled nucleotide excision repair tc ner 0.25544769049586163 1.992501075532455 0.04631610729375879 1.0 0.16128061213637654 63 P40938,Q13620,P18858,P30876,P24928,Q07864,P35249,P19387,Q7L5N1,P23193,O60306,P15927,Q16531,P62487,P28340,P35250,P12004,Q9UNS2,P61201,P18887,P40937,P18074,Q9HCS7,P41440,Q9Y2S7,Q9BT78,P62875,Q13098,P35251,P19447,P49916,Q9UMS4,Q93009,Q92905,Q99627,P27694,P19388 Activated ntrk2 signals through cdk5 0.6176946592339427 1.9923963708320453 0.04632758523112024 1.0 0.16128061213637654 2 P63000 Iron uptake and transport 0.3516530977181421 1.9884125622151085 0.046766080584586645 1.0 0.16224881106179312 23 P02786,P21283,Q86VP6,P09601,P30519,Q13616,O76003,Q9UI12,Q93050,P38606,Q9Y487,P63208,P21281 Glucuronidation 0.6570143884892214 1.9878933861073649 0.046823482386960436 1.0 0.16224881106179312 3 Q16851,Q9NUJ1 Rab regulation of trafficking -0.2938589561651867 -1.9856879800568352 0.047067980491452444 1.0 0.16271761237184254 71 Q9ULP9,Q8WXG6,Q9Y5R8,Q8WVT3,Q8IWF6,Q86VX9,P20336,Q9UL33,Q9NZ52,Q9H082,Q9NRW1,Q9HA65,Q6ZUT9,P51159,A5PLN9,Q96QF0,Q9Y243,Q86SZ2,P26374,Q96CV9 Assembly of active lpl and lipc lipase complexes 0.5496224379719443 1.973569860719132 0.04843067360800002 1.0 0.16704098073129636 1 Fceri mediated mapk activation -0.4400249486915253 -1.963627647683946 0.04957328872510858 1.0 0.1705870674374406 18 P16885,O14733,P45983,P45984,P05412,P01111,P52735,P29353 P75ntr signals via nf kb -0.6133088746592597 -1.9621273657901792 0.049747657623437025 1.0 0.17079264944451883 6 Q04206,P19838,O14920,P41743,P51617 Er to golgi anterograde transport 0.21576847983487188 1.9590183233824237 0.050110640950971064 1.0 0.17164334486654456 106 Q08379,P49257,Q9Y678,O95487,P49755,Q15436,Q5H9R7,P63167,O75396,Q9BVA1,P62820,O95486,O00743,Q13885,Q9HCU5,O60763,P53618,Q9BUF5,P68371,Q15363,Q5JRA6,P53621,O75935,Q14789,Q12955,Q99747,Q9Y296,O14579,Q9Y6G9,Q92734,P46459,Q13813,P52907,Q12907,O94979,Q96FJ2,Q8WVM8,Q14203,P35606,Q8IUR0,P24390,Q9BVK6,P61923,Q9UBF2,Q96PC5,Q9UJW0,Q13409,P48444,P54920,O15498,Q01082,Q9Y3B3,P47755,P47756,Q9H0U4,Q9Y6Y8,P61163,Q13190,Q92538,P53992,Q8N6T3,P18085,Q14204,Q13561,O15027 Toll like receptor tlr1 tlr2 cascade -0.3280800320500929 -1.9555814788697772 0.050514476454581736 1.0 0.17262974751680454 41 Q9UKB1,P19838,P45984,P05412,Q9Y297,Q9Y6K9,P16220,O14733,P49137,Q13404,P45985,Q00653,P46734,Q13164,Q16644,P45983,P52564,P18846,P51617 Toxicity of botulinum toxin type d botd -0.5557353469974935 -1.9516048949879936 0.050985131642899084 1.0 0.17344257111397177 1 Q7L0J3 Neurotoxicity of clostridium toxins -0.5557353469974935 -1.9516048949879936 0.050985131642899084 1.0 0.17344257111397177 1 Q7L0J3 Jnk c jun kinases phosphorylation and activation mediated by activated human tak1 -0.5413592671371473 -1.9505351990422368 0.051112362262391686 1.0 0.17347931610697864 10 O14733,P45983,P45984,Q13404,Q9Y6K9,P45985,P51617 Hcmv early events 0.2525127300457144 1.9484410425985599 0.051362212900453175 1.0 0.17348000515762071 62 Q99567,Q8N1F7,Q12769,Q8TEM1,P49792,Q8WUM0,P49790,P78406,Q9BUF5,P62805,P57740,Q15022,Q9Y6G9,P05556,P35658,Q92621,P83916,Q5SRE5,Q9NRG9,Q7Z3B4,Q9BTX1,Q9BW27,P52948,Q13263,P12270,O75694,Q8NFH4,Q14204,Q9UKX7 Gap junction assembly -0.5409718797038998 -1.9479707898856682 0.05141845838506409 1.0 0.17348000515762071 10 P17302,P68366,Q9BQE3,P36383 Interleukin 1 processing -0.6669064748201595 -1.9472077795575597 0.05150982939694626 1.0 0.17348000515762071 3 Q00653,P19838,Q04206 Extension of telomeres 0.2861434007813035 1.9452012130135028 0.05175076591729466 1.0 0.17348000515762071 41 P40938,P09884,Q9Y230,P18858,Q5H9R7,P35249,O00743,P49643,P15927,P28340,O60832,Q9Y265,Q9NX24,P24941,P39748,P35250,P12004,P40937,P41440,Q9NY12,Q9Y2S7,P35251,P27694,P49642 Formation of xylulose 5 phosphate 0.6485896678499954 1.9448355671567776 0.05179477190260151 1.0 0.17348000515762071 3 Q7Z4W1 Mitochondrial fatty acid beta oxidation of saturated fatty acids 0.5493454752367217 1.9446996103147014 0.05181114247996055 1.0 0.17348000515762071 8 P30084,P11310,P55084,Q16836 Glucagon signaling in metabolic regulation -0.501546846596062 -1.9342056206974645 0.053087851603773606 1.0 0.17640379719439614 13 P31323,P62879,Q9HAV0,P22694,P31321,O60266 Vasopressin regulates renal water homeostasis via aquaporins -0.501546846596062 -1.9342056206974645 0.053087851603773606 1.0 0.17640379719439614 13 P31323,P62879,Q9HAV0,P22694,P31321,O60266 Sumoylation of dna methylation proteins -0.5563278617233554 -1.933749306823902 0.05314395829888796 1.0 0.17640379719439614 9 Q9UBC3,P35226,Q06587,O00257 Aryl hydrocarbon receptor signalling 0.6464028776978563 1.9336357967325142 0.053157922778714006 1.0 0.17640379719439614 3 P08238,Q15185 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 0.6512128399108295 1.929620317684626 0.05365389947403032 1.0 0.17710753161666742 5 P12235,P05141,P12236 Calcineurin activates nfat -0.6634214728893677 -1.9288682756348576 0.05374721711547936 1.0 0.17710753161666742 3 Q12968 Hsf1 activation 0.4019532760661033 1.928811043991953 0.05375432428718874 1.0 0.17710753161666742 18 Q92598,P08238,P0DMV9,Q02790,P07900,P25685,P62258,P27694,P55072,P50454 Tp53 regulates transcription of cell death genes -0.44898977229191034 -1.9280778455582308 0.053845444176074064 1.0 0.17710753161666742 17 Q658P3,Q07812,Q13625,Q92793,P55212,Q13315,Q92597,O14727,Q13794,Q53FA7,P42575,P24386,Q9Y255 Signaling by rho gtpases miro gtpases and rhobtb3 0.11632819738525478 1.9219158660404323 0.054616345079692596 1.0 0.17887723263054717 400 Q9BX68,P21333,P53350,O60341,Q8IXI1,Q13838,P49257,P60660,P67936,Q14008,P46060,Q96HY6,P35579,Q9H0H5,P61604,P49792,P60953,Q9BSJ8,P28288,Q00610,Q08378,Q16513,P43034,Q9Y2A7,P57740,Q99661,Q9P2R3,P51572,Q9Y6G9,P46940,Q9UH62,Q14160,P31948,Q99707,P62995,Q9P258,P61201,P08238,Q9NRG9,P16104,Q8WWQ0,Q12792,P07900,Q86UP2,Q8IWA4,Q9BW27,Q13409,P62993,P52948,Q15334,O60610,Q13492,Q9BT78,O00139,P02786,Q9NNW5,O95140,O14980,O43663,P42166,Q13190,Q15691,P11182,Q8NFH3,P30153,P07910,Q01968,Q9Y512,Q13505,Q9Y266,P33176,Q9UEY8,A4D1P6,Q12769,Q14738,P20700,Q99570,P62258,O15173,Q9NSV4,Q14126,Q8NHP6,P31946,Q15005,Q7Z6E9,P28482,Q04917,Q02952,Q9Y2U8,P51149,P14923,P27348,P05556,Q07021,O75489,Q16543,Q8WVM8,P12814,P35580,Q14254,P06753,O43396,Q01082,O15498,Q96CS3,P47756,O75976,P41240,Q07065,O15144,Q9UQB8,P08670,P51648,Q14344,O43684,Q86XL3,Q99832,P30154,P34897,P30519,Q8N684,P63000,Q14739,P55072,Q8WUM0,Q9NYL9,P62140,Q9BUF5,O15145,P62805,Q7L576,Q15904,Q5JTV8,P12277,P50402,Q15758,P35080,Q13177,O95202,Q13813,Q6IAA8,Q96N67,Q68EM7,P38159,Q92747,Q96T58,Q8IYB3,Q13098,O75955,Q96AC1,O43264,Q96EE3,Q9BXB4,Q16643,Q13618,P61158,P35221,Q9H2G2,P52565,P61160,P63167,O95292,Q9BVA1,Q16718,Q13112,Q8IXI2,Q07866,P07737,P23528,P78371,Q2NKX8,Q93008,P42167,O60664,Q92974,P63104,P61981,P40227,P59998,Q9UM54,O60566,P15924,Q14247,Q7Z460,P35222,Q8NFH4,Q14204,Q5VTR2 Keratan sulfate biosynthesis -0.6062877734432793 -1.9214196205736063 0.054678826917176515 1.0 0.17887723263054717 6 O60512,Q9Y274,Q11206,Q9NY97,P15291 Polymerase switching on the c strand of the telomere 0.3875972056324932 1.9209053886793985 0.05474363629498624 1.0 0.17887723263054717 19 P40938,P09884,P35251,P28340,P40937,P12004,P35249,Q9Y2S7,P35250,P49643 Notch4 intracellular domain regulates transcription -0.6058956649201679 -1.919140947503194 0.054966498533939756 1.0 0.17921243504501147 6 Q92793,Q92830,Q09472 Termination of translesion dna synthesis 0.34351219774668895 1.916652637505619 0.05528207604483293 1.0 0.17984780197991498 23 P27694,Q14258,P35251,P28340,P40937,Q07864,P35250,P35249,Q9Y2S7,Q14694,P12004 Maturation of sars cov 1 nucleoprotein -0.7036145053891253 -1.910332155995247 0.056090460029158296 1.0 0.18208014257831343 4 Q8IXQ6,Q9UKK3 Fcgr3a mediated il10 synthesis -0.44641433441731215 -1.9071470745376464 0.056501544799986814 1.0 0.18235231362869098 17 Q14571,P12931,P06241,P31323,P16220,P31321,P22694,P16885,O60266 Runx3 regulates notch signaling -0.6702389111520204 -1.9068388741160998 0.05654145563520485 1.0 0.18235231362869098 5 Q92793,Q92830,Q09472 Regulation of gene expression in late stage branching morphogenesis pancreatic bud precursor cells -0.6702389111520204 -1.9068388741160998 0.05654145563520485 1.0 0.18235231362869098 5 Q92793,Q92830,Q09472 Neddylation 0.20704813378031017 1.9039695322239418 0.05691415232979469 1.0 0.18313875846774136 114 Q06323,O43242,P28074,P62191,P17980,P51665,Q13620,P62333,P61081,Q13617,P25788,Q13616,P49721,P35998,O00231,Q99460,P63208,Q9Y5A7,Q7L5N1,O14818,Q9UL46,P48556,P28070,P49720,Q16531,Q15370,O75832,P61201,P25789,P43686,Q99436,P25787,Q15008,Q9BT78,P25786,O00487,P28066,Q9UNM6,Q92905,Q99627,P62195,Q86VP6,P60900,P20618,Q13618,Q13200,P61289,O00232 Dopamine neurotransmitter release cycle -0.6694643658730475 -1.9027904744701631 0.05706789065427165 1.0 0.18313875846774136 5 O14795,P20336,Q9NUP9 Dag and ip3 signaling -0.41959582647182786 -1.9021309124088797 0.05715404207214747 1.0 0.18313875846774136 19 Q14571,Q96RR4,P31323,Q16566,P25098,P16220,P31321,P22694,O60266 Receptor type tyrosine protein phosphatases -0.7016567140737613 -1.9005945810606433 0.05735513585270047 1.0 0.18338873909983627 4 Q13332,Q86W92 Signaling by wnt in cancer 0.4913427923994517 1.8982249470580235 0.057666455853452536 1.0 0.1839893345217222 11 P35222,Q14738,P30153,P48729,P56545,Q13363 Attachment and entry -0.6566704675939127 -1.8932436710671854 0.05832547224266582 1.0 0.1856943453879745 3 P07711,Q9BYF1 Myd88 independent tlr4 cascade -0.31585953369116676 -1.890729146450721 0.058660509615687806 1.0 0.1863628130647651 46 Q9UKB1,P19838,P45984,P05412,Q9Y297,Q9Y6K9,P16220,O14733,P49137,Q13404,P45985,Q00653,P46734,Q13164,Q16644,P45983,P52564,P18846,P51617,Q13158 Pi metabolism -0.3250752740863142 -1.8889117827814403 0.05890365036806822 1.0 0.18673710435834392 39 O15357,Q8TCG2,Q8NEB9,Q9Y2I7,O95248,Q12923,Q9BT40,Q08AM6,Q9HAU0,O43426,Q13613,P48426,Q9NZC3,Q13496,P78356,Q9NYA4,Q9C0I1,O95379 Pi5p regulates tp53 acetylation -0.566172281543436 -1.8866494019204525 0.059207497411366106 1.0 0.18728657694615192 8 Q09472,P48426,Q9H160,P78356,P52564 Regulation of tnfr1 signaling -0.4567435217245947 -1.8851330344679689 0.05941187903873124 1.0 0.18728657694615192 16 Q8WXG6,Q96EP0,P98170,Q9Y6K9,Q96BN8,Q86VP1,Q12933,O14920,Q13158,Q13107,Q14790 Ptk6 regulates cell cycle 0.5980938680093406 1.884820613068798 0.05945406100371131 1.0 0.18728657694615192 2 P11802 G protein activation -0.5827252148893755 -1.8833062183647642 0.05965888120278562 1.0 0.18753530167120375 7 P50148,P62873,P62879,Q9HAV0,P29992 Alk mutants bind tkis 0.5566477712297199 1.878650196040852 0.06029227238711776 1.0 0.18912733864590625 7 Q00610,P06748,P10644,Q9NR09 Signaling by nuclear receptors -0.26538233740127765 -1.8743393948590188 0.060883660966293274 1.0 0.19058120764659028 106 O60563,P52655,Q05513,P29353,Q9Y4C1,Q9UPQ9,P05412,Q15119,O75911,P16220,P14859,P01111,P62879,Q9HAV0,Q92993,Q8NDV7,P02654,Q9UL18,P52657,P00533,P28702,P29373,P01106,Q8N257,P08047,Q92793,Q09472,O43524,Q9Y243,O15379 Energy dependent regulation of mtor by lkb1 ampk -0.4546506493881316 -1.8685605273821575 0.061683981772447494 1.0 0.19268162021162843 16 Q9UHA4,O43504,Q9HB90,Q9Y478,Q9H9S4,Q0VGL1 Sealing of the nuclear envelope ne by escrt iii -0.4025390896848872 -1.8667042024120584 0.061942906571671674 1.0 0.19308562927152886 20 Q9BY43,Q9BQE3,P68366,Q9UBP0,Q5T0F9 Carnitine metabolism 0.5719003185105848 1.8603563913345267 0.06283512014466286 1.0 0.19545788938527695 6 O00763,Q13085,O43772,P23786 Cellular senescence -0.2775244357404298 -1.8590408144357267 0.06302135339694437 1.0 0.19562878450301482 83 P19838,O00257,O00716,Q9Y294,Q9UM13,Q9UPQ9,P45984,P05412,Q8N4C8,Q8IW41,O14733,P49137,Q92993,Q8NDV7,Q9UL18,P46734,Q8N257,P08047,O95503,Q13164,Q9Y6J0,P45983,Q16644,Q9NPG3,P35226,P52564,Q06587,P52926 Keratan sulfate degradation 0.6370046799124336 1.8579338907423524 0.06317840291419108 1.0 0.19570856619988503 5 P15586,P16278,P07686 Insulin receptor recycling 0.4846053700272382 1.8547938864824705 0.06362566540245362 1.0 0.1966851482358006 11 P61421,P21283,Q15904,Q9UI12,Q93050,P38606,Q9Y487,P21281 Regulation of fzd by ubiquitination -0.5400934915498125 -1.8531239083338031 0.06386460073844358 1.0 0.19701502091155473 1 P40818 Toll like receptor 9 tlr9 cascade -0.3142993249046142 -1.8370139594047161 0.06620783464780278 1.0 0.2038216397215416 44 Q9UKB1,P19838,Q8NEB9,P45984,P05412,Q9Y297,Q9Y6K9,P16220,O14733,P49137,Q13404,P45985,Q00653,P46734,Q13164,Q16644,P45983,P52564,P18846,P51617 Flt3 signaling by cbl mutants -0.5372168284789746 -1.8349114327285978 0.06651881341990151 1.0 0.20403421075456576 1 P22681 Signaling by notch3 -0.4755427981024538 -1.8346395575688599 0.06655911340443743 1.0 0.20403421075456576 14 O00308,Q92793,Q09472,Q86YT6,Q92830,P49768,P00533 Runx1 regulates transcription of genes involved in bcr signaling -0.6027692860996392 -1.8337730371311218 0.06668769170300237 1.0 0.20403421075456576 2 Q13951,Q15723 Heme signaling -0.44998445627601824 -1.8314958442285028 0.06702656742579505 1.0 0.20465078988613652 16 Q7Z5J4,Q92793,Q09472,O14867,O15379,P04114,Q9BZK7,Q9BX63,Q96RS0,P16220 Ire1alpha activates chaperones 0.29488212285515136 1.8288069020541216 0.06742854065098403 1.0 0.20545710750504337 33 Q9HCU5,Q13217,Q14203,Q9Y4L1,P08240,Q9Y490,O14773,Q15084,P35611,P02545,P51858,Q06210,P43307,Q9Y5M8,Q8N6T3,O94979 Ptk6 regulates rtks and their effectors akt1 and dok1 -0.6437552528829924 -1.8247353830730857 0.06804097103719897 1.0 0.20690009560291114 3 Q96P48,P31749 Chrebp activates metabolic gene expression 0.6293630802447353 1.8192432913762104 0.06887432081335354 1.0 0.2090076130588529 5 Q13085,Q99943,P53396,P49327 Sumo is proteolytically processed -0.5997122819636923 -1.8164348880752144 0.06930368750253546 1.0 0.20988311865605253 2 Q9P0U3,P61956 Killing mechanisms -0.6839069794297589 -1.811867924301877 0.07000660663776159 1.0 0.21048275902110125 4 P05412,P45983 Formation of fibrin clot clotting cascade 0.6225746739086989 1.8110137152397352 0.0701387286409405 1.0 0.21048275902110125 3 Q07021 Ntrk2 activates rac1 -0.5987485051169851 -1.8109628746401925 0.07014659869226847 1.0 0.21048275902110125 2 P06241 Scavenging by class f receptors 0.6276839703960552 1.8107298335762452 0.07018268238619729 1.0 0.21048275902110125 5 Q92598,P27797,Q9Y4L1 Synthesis of prostaglandins pg and thromboxanes tx 0.6596510163698402 1.8090158700181342 0.07044853787704897 1.0 0.21048275902110125 4 Q15185,P16152,Q8N8N7 Cdc6 association with the orc origin complex -0.5201246497216149 -1.8088718084927977 0.07047092106658859 1.0 0.21048275902110125 10 O43929,Q9Y5N6,Q9UJA3,O00716,Q13415 Resolution of d loop structures through synthesis dependent strand annealing sdsa -0.40879816150739207 -1.8078374815028933 0.07063179832922861 1.0 0.21048275902110125 19 Q06609,Q9H9A7,O43502,Q96B01,O43542,Q92993,Q9BX63,Q13315,Q99728,Q13472,Q9NZ71,Q14191 Resolution of d loop structures -0.40879816150739207 -1.8078374815028933 0.07063179832922861 1.0 0.21048275902110125 19 Q06609,Q9H9A7,O43502,Q96B01,O43542,Q92993,Q9BX63,Q13315,Q99728,Q13472,Q9NZ71,Q14191 Adaptive immune system 0.14093389240239626 1.8011789280449853 0.07167468253272258 1.0 0.2129841303224405 301 P62191,P25788,P35998,O14818,P60953,P27824,Q00610,Q99661,Q9Y6G9,P51572,P30260,P27797,P50570,P68036,P22314,Q99436,P29144,P62993,P52732,Q15008,P25786,O00487,P61163,O94874,P30153,Q9C0C9,P60900,Q13200,P61289,O43242,P28074,P33176,P62333,P61081,Q13617,Q14738,Q13616,O00231,Q99460,P63208,P31946,Q9UL46,P48556,Q5T4S7,P49720,Q10567,Q96CW1,P51149,P05556,O94979,O75832,Q14203,Q9UJW0,Q9UJX3,P10619,Q92990,P42345,P55786,P63010,P52888,P41240,P47756,Q9UNM6,P53992,P20618,Q13561,A0AVT1,Q06323,P61086,P17980,Q15436,P49721,P28070,Q9BUF5,O75935,P30101,Q13177,P52907,Q15370,Q9UJX4,P25789,P09429,P25787,O95239,O94973,P28066,Q7Z6Z7,Q13618,O00232,Q02241,P60468,P51665,Q9ULT8,Q14807,O75396,Q07866,Q13867,P10321,P04439,P63104,O43747,P43686,P61619,Q14669,P62195,Q14204 Tnf signaling -0.39524605172659644 -1.8006563002020959 0.07175706941064774 1.0 0.2129841303224405 20 Q8WXG6,Q96EP0,O43318,P98170,Q9Y6K9,P78536,Q86VP1,Q96BN8,Q12933,O14920,Q13158,Q13107,Q14790 A tetrasaccharide linker sequence is required for gag synthesis -0.6388613092745912 -1.7986556717530595 0.07207316504921368 1.0 0.21349704954936063 3 O94766,Q9H1B5 Tysnd1 cleaves peroxisomal proteins 0.5606487565500982 1.7971508519570654 0.07231167456824994 1.0 0.21377856171962778 6 Q15067,P22307,P51659 Phosphorylation of the apc c 0.4362764033219353 1.79117909515684 0.0732645597379955 1.0 0.21616672081111543 14 Q16763,P30260,Q9UJX4,P53350,Q9H1A4,P14635,P06493,Q9UJX3,Q9UJX2 Flt3 signaling -0.49341573816036377 -1.7882801789007903 0.073730816080122 1.0 0.21711248213316556 12 P51692,P06241,Q13322,O43524,P01111,Q9Y243 Unwinding of dna 0.4607640542976208 1.7833287263238176 0.0745328078730183 1.0 0.21904119079052717 12 P33992,P25205,Q14566,P33991,P33993,P49736 Mhc class ii antigen presentation 0.22399455762685558 1.7794866392958246 0.07516001341983758 1.0 0.22044964566054726 76 Q9NZ32,P53680,P33176,Q14807,O95487,Q15436,P63167,Q9BVA1,O95486,Q9H0H5,Q13885,P27824,Q07866,Q00610,O95782,Q9BUF5,P68371,Q10567,Q96CW1,O75935,P51149,Q99661,Q9Y6G9,P52907,P50570,O94979,Q96FJ2,Q14203,O43747,O95235,P09496,Q9UJW0,O95239,P53634,P52732,Q13409,P10619,O00139,P63010,P47755,P47756,O94973,Q9BXS5,P61163,P53992,Q14204,Q13561,Q02241 Copi independent golgi to er retrograde traffic 0.27723479578743887 1.7733945739635657 0.07616334749128884 1.0 0.22295361053442114 36 Q9NP72,Q9NZ32,Q9H2M9,P63167,Q9BVA1,Q13885,O43237,Q10472,Q15102,Q9BUF5,P68371,Q10471,P43034,O75935,Q9Y6G9,P52907,Q96FJ2,Q14203,Q15042,Q8TD16,Q9UJW0,Q13409,P47755,P47756,P61163,Q14204,Q13561 Vldl assembly -0.6331658290485277 -1.7682231462187445 0.07702360614718895 1.0 0.22455234019569797 3 P02654,P04114 Met interacts with tns proteins 0.5768746628304163 1.7673979291675757 0.07716160951690942 1.0 0.22455234019569797 2 P05556 Met activates pi3k akt signaling 0.576874662830415 1.7673979291675666 0.07716160951691098 1.0 0.22455234019569797 2 P62993 Zinc efflux and compartmentalization by the slc30 family -0.6323741007194318 -1.7639858596002886 0.07773435992799982 1.0 0.2257781604146583 3 Q8TAD4,Q8NEW0,Q6NXT4 Recycling pathway of l1 0.3074432921806398 1.7628917811381637 0.07791874349973904 1.0 0.22587340041753146 28 P51812,P26038,Q00610,P15311,Q16555,O95782,Q9BUF5,P35241,P28482,P53680,P63010,Q96CW1,O94973,O95239,Q9BVA1,Q15418,P50570 Nef mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 0.4443531345524009 1.7588138954581929 0.07860912383836993 1.0 0.2271363442188005 13 P63010,O94973,Q9BXS5,P53680,Q10567,O43747,Q96CW1,P04439,Q9UI12 Sphingolipid metabolism 0.27112701729529376 1.758336706617828 0.07869023555538224 1.0 0.2271363442188005 39 P16278,O95292,P06865,Q9BSJ8,P07602,Q9NZJ7,Q96G23,P17900,P07686,A0FGR8,P22059,P10619,O43681,Q9NXE4,P06280,O95470,Q9P0L0,Q13510,Q06136,O15269,P51648,P04062 Pka mediated phosphorylation of creb -0.5290880005003997 -1.757622641726261 0.0788117382289395 1.0 0.2271363442188005 9 P16220,P31323,P22694,P31321,O60266 Opioid signalling -0.31722471353270737 -1.753845824897647 0.07945692856061881 1.0 0.22855371342726258 36 Q96RR4,P50148,Q16566,P31323,P62879,Q9HAV0,P25098,Q01970,P16220,P31321,P22694,O60266 Gdp fucose biosynthesis -0.672010453272305 -1.7519610815359368 0.07978050023190142 1.0 0.2290422839027613 4 A2VDF0,O14772 Rho gtpases activate ktn1 0.4980061526090104 1.7453144446891726 0.08093014892473915 1.0 0.23183613868643582 9 P60953,Q07866,P61586,P33176,P63000,Q86UP2,P84095 Mitotic g2 g2 m phases 0.18530132494201965 1.7445406982439269 0.08106485117827722 1.0 0.23183613868643582 135 O43242,P28074,P62191,P17980,P51665,Q13561,P62333,P07437,Q14008,P25788,P06493,Q13616,P62258,P35998,O00231,Q99460,P63208,P49721,O14818,P48556,P28070,P49720,O75832,Q14203,P25789,P08238,P43686,Q99436,P07900,P25787,Q9BSJ2,Q15008,P25786,O00487,O14980,P04637,P28066,Q9ULW0,P61163,Q9UNM6,Q15691,P62195,P30153,P60900,P20618,Q14204,Q13200,P61289,O00232 Class b 2 secretin family receptors -0.5432867710491105 -1.7431478136273415 0.08130779848069314 1.0 0.23206679289551993 8 Q9HAV0,P48960,P08174,P62879 Chk1 chk2 cds1 mediated inactivation of cyclin b cdk1 complex 0.4418272980547694 1.741658768234032 0.08156817135597239 1.0 0.23206679289551993 13 P63104,P61981,Q04917,P06493,P62258,P27348,P31946 Tyrosine catabolism 0.5721992447401448 1.7414042068537992 0.08161275132701507 1.0 0.23206679289551993 2 P16930 Uptake and function of diphtheria toxin 0.6454398273070481 1.7401043170260801 0.08184070236996899 1.0 0.23207083200809844 4 P07900,P08238,P13639 P75ntr regulates axonogenesis 0.6087878698531441 1.7396205052005702 0.08192567626594616 1.0 0.23207083200809844 3 P52565 Chondroitin sulfate dermatan sulfate metabolism -0.4973600152282507 -1.7332315861814624 0.08305451502230521 1.0 0.23411147913559302 11 Q9UL01,Q9P2E5,Q8N6G5,O94766,Q9H1B5,Q9Y2C2,Q9NRB3 Dual incision in gg ner 0.2927498695839559 1.7327107553041894 0.08314709190911218 1.0 0.23411147913559302 31 P40938,P27694,P35251,P15927,Q13620,Q16531,P28340,P19447,P40937,P18074,Q07864,Q86WJ1,P12004,P41440,P35249,Q9Y2S7,P35250,P09874 Diseases associated with n glycosylation of proteins -0.42514491253189224 -1.7323024176984294 0.08321973174118136 1.0 0.23411147913559302 17 Q9H3H5,Q9H553,Q96AA3,Q9BVK2,Q9H6U8,Q96F25,Q9UKM7,Q9NP73,Q9Y672,P15291,Q10469 Notch2 intracellular domain regulates transcription -0.6680044843723383 -1.7317110404806717 0.08332502391627816 1.0 0.23411147913559302 4 Q09472,P16220 Wnt ligand biogenesis and trafficking 0.5489322568517501 1.7311126489060005 0.08343167477919455 1.0 0.23411147913559302 6 O60493,Q9UBQ0,O75436,Q96QK1 Transport of nucleotide sugars -0.5843691466432517 -1.728995397713351 0.08380991877424959 1.0 0.23473078754442084 2 Q9Y2D2 Clec7a inflammasome pathway -0.667026443605009 -1.7267612446594856 0.08421055137603317 1.0 0.23496951601177796 4 Q9UDY8,P19838,Q04206,Q14790 Sumoylation of immune response proteins -0.667026443605009 -1.7267612446594856 0.08421055137603317 1.0 0.23496951601177796 4 Q00653,Q04206,Q9Y6K9,Q8N2W9 Advanced glycosylation endproduct receptor signaling 0.4946396890593522 1.7246256063608114 0.08459496571313307 1.0 0.2356009325468566 9 P47755,P28482,P39656,P27361,P09429,P52907,P14314 Signaling by tgfb family members -0.307651117471322 -1.722886417412397 0.08490906705024215 1.0 0.23603453340459102 42 O00255,O60563,P08047,Q13485,P28749,P36873,Q12841,P36896,P24863,Q9NYA4,O95405,P49336,Q6ZSZ5,Q9P2M7,Q05513,P01106,Q14919 Ethanol oxidation 0.6416584334846231 1.721726248292392 0.08511912013264511 1.0 0.23617781936246035 4 P11766,P05091 Cooperation of prefoldin and tric cct in actin and tubulin folding 0.3239591842374426 1.7123373269677313 0.08683452158267824 1.0 0.24048966014533563 22 P17987,Q99832,P61758,Q9BUF5,P78371,P40227,Q9UHV9,P48643,P50991,P50990,P49368 Nuclear events stimulated by alk signaling in cancer 0.4367911802995238 1.7074383006187204 0.08774061658833077 1.0 0.24254827220150807 13 Q00610,P06748,P28482,P33176,P40763,Q13616,P62753,P51608,P63208,Q9HC35 P75ntr recruits signalling complexes -0.6627794055177116 -1.705240969350991 0.08814949196203337 1.0 0.24284601238167958 4 P51617,P41743 Telomere c strand lagging strand synthesis 0.3011851998501383 1.7051079649701555 0.08817429040167024 1.0 0.24284601238167958 28 P40938,P27694,P09884,P15927,P35251,P18858,P28340,P40937,Q9Y2S7,P12004,P41440,P35249,P49642,P39748,P35250,P49643 Met activates rap1 and rac1 0.5435509099544018 1.7007161901324193 0.08899629346169635 1.0 0.24422165247177005 6 P63000,Q96N67,P46109,P62993 Binding of tcf lef ctnnb1 to target gene promoters -0.579275407968929 -1.69981627512324 0.08916548922459255 1.0 0.24422165247177005 2 P01106 Runx3 regulates wnt signaling -0.579275407968929 -1.69981627512324 0.08916548922459255 1.0 0.24422165247177005 2 P01106 Aquaporin mediated transport -0.45693348971874964 -1.6940699791733054 0.09025198617032859 1.0 0.24674396219043962 14 P31323,P62879,Q9HAV0,P22694,P31321,O60266 G alpha i signalling events -0.2987585103885879 -1.6913322746158868 0.09077335919971574 1.0 0.24771484470252098 47 Q14571,Q96RR4,P50148,O43665,Q16566,Q9UK39,P62879,Q9HAV0,P31323,P25098,Q01970,P22466,P16220,P31321,P22694,O60266,Q9ULM6 Dap12 interactions -0.4797139066927471 -1.6902841156801929 0.09097361249980018 1.0 0.2478074636649036 12 P13747,P06241,P01111,P52735,P16885,P29353 Er quality control compartment erqc -0.5021284705195224 -1.6870938305800816 0.091585311158489 1.0 0.249018455522169 10 Q13438,Q8WU17,Q9UKM7,Q9NYU1,Q9UKV5,Q86TM6,O60858 Signaling by notch 0.20175101856388844 1.6856112846055824 0.09187069425725203 1.0 0.2493394070005565 94 Q06323,Q9HCE1,O43242,P28074,P62191,P17980,P51665,P62333,P25788,Q13616,P49721,P35998,O00231,P63208,Q99460,O14818,P16615,Q9UL46,P48556,P28070,P49720,P62805,O75832,P63104,P25789,P43686,Q99436,P25787,Q15008,P25786,O00487,P04637,P28066,Q9UNM6,P62195,P60900,P20618,Q92769,Q13200,P61289,O00232 Glucagon like peptide 1 glp1 regulates insulin secretion -0.44345249965385125 -1.6808746580232765 0.09278726328463827 1.0 0.2513691314438382 15 Q14571,P24588,P31323,P62879,Q9HAV0,P22694,P31321 Regulation of gene expression in early pancreatic precursor cells -0.5125854009349251 -1.677746099310563 0.09339667580881872 1.0 0.2525608837661341 1 O00330 Regulation of tp53 activity through acetylation -0.33476664885883195 -1.6747891307743696 0.0939756122090929 1.0 0.25311301549361526 29 Q9HAF1,Q8WYH8,Q92794,Q9ULD4,Q12873,P29590,Q9H160,P31749,Q09472,P78356,P48426,Q9Y243,P52564,P55201,Q9NPI1 Cdc42 gtpase cycle -0.27610964214429734 -1.674021989339511 0.09412627782035643 1.0 0.25311301549361526 66 Q658P3,Q5T5U3,Q6ZW31,Q13459,O75044,P52735,Q96RU3,Q9NZN5,Q9NP61,Q96P48,O15085,Q8N5V2,Q12979,Q9Y597,O15013,Q562E7,Q15836,Q5T0N5,Q8WUY9,Q9NRY4,Q9Y2X7,Q96HP0,A1A4S6 Assembly of the hiv virion -0.5482789774454804 -1.6735618057342896 0.09421675019547093 1.0 0.25311301549361526 7 Q96EY5,O60551,A5D8V6,Q9UK41,Q9NZ09 Organic anion transporters 0.5599712281963571 1.6732385130883576 0.09428035140869562 1.0 0.25311301549361526 2 Q9UBX3 Triglyceride biosynthesis 0.5007191657677001 1.669528430300755 0.09501270085911973 1.0 0.2541378413402529 1 Meiotic synapsis 0.3435354007777921 1.66839445122145 0.09523744905209774 1.0 0.2541378413402529 20 Q8WXH0,P16104,P62805,Q8N3U4,Q9UH99,P02545,P20700,P54652,O60216,Q9UQE7,O94901,Q14683,Q9BTC0 Adp signalling through p2y purinoceptor 1 -0.5153925384956818 -1.6678264665407945 0.09535018032464926 1.0 0.2541378413402529 9 P12931,P50148,P62873,P62879,Q9HAV0,P29992 Ros and rns production in phagocytes 0.4680474192221941 1.6676245471243374 0.09539028220227053 1.0 0.2541378413402529 10 P61421,P21283,Q9UI12,Q93050,P38606,Q9Y487,P21281 Synthesis of ip3 and ip4 in the cytosol -0.5312779036972213 -1.6669975432168573 0.09551489338962527 1.0 0.2541378413402529 8 Q01970,O43426,P16885,Q8N3E9 Processing of smdt1 0.4180265887636385 1.6640921097262258 0.09609402361538999 1.0 0.254903859120352 14 Q99623,O75439,Q10713,P35232,Q9Y4W6,Q96TA2,Q9UJZ1,Q9BPX6 Phosphorylation of emi1 0.6297680456709666 1.6638373110280333 0.0961449455205623 1.0 0.254903859120352 4 P06493,P53350 Stimuli sensing channels -0.3924371137454842 -1.662953544810795 0.0963217349035752 1.0 0.25491897869685093 19 Q9Y3S1,P04049,Q96BR1,Q86WC4,Q9BYP7,Q8TEL6,Q99576,P51797 G alpha s signalling events -0.4409643619912201 -1.6613105198853666 0.09665109829938823 1.0 0.25533712139377385 15 P32121,P12931,P62873,O60658,P25098,P62879,Q9HAV0,P49407,O60266 Runx2 regulates osteoblast differentiation -0.4979224696749524 -1.6584108703411502 0.09723456399571284 1.0 0.2564238944311719 10 Q9UPW6,P12931,P46937,O15379,Q9UBN7 Collagen degradation -0.6526353660730745 -1.6536695563871924 0.09819467150504657 1.0 0.25849834018112966 4 Q13443,P07858,P07711,P78536 Complement cascade -0.622150471007921 -1.6523322563446883 0.09846683711601978 1.0 0.2587576495641437 5 P60033,P15529,P08174 Rho gtpase cycle 0.13459782236532855 1.647109609805544 0.09953551824520601 1.0 0.2611054968052059 247 Q13838,P61604,P60953,Q9BSJ8,P28288,Q00610,Q16513,Q9Y2A7,P46940,P51572,Q14160,P31948,P62995,P61201,P08238,Q9NRG9,P07900,Q86UP2,P62993,O60610,Q13492,Q9BT78,P02786,Q9NNW5,P42166,P07910,Q9Y512,Q13505,Q9Y266,P20700,Q14126,P51149,P14923,P05556,Q07021,Q16543,Q8WVM8,O75489,P12814,Q14254,P06753,O15498,Q01082,Q96CS3,P41240,P47756,O75976,Q07065,Q9UQB8,P08670,P51648,Q86XL3,Q99832,P34897,P30519,Q8N684,Q14739,P55072,Q9NYL9,Q7L576,Q15904,P50402,P12277,Q15758,Q13177,O95202,Q13813,Q6IAA8,Q96N67,P38159,Q96T58,Q8IYB3,Q13098,O75955,Q16643,Q13618,Q9H2G2,P52565,O95292,Q13112,P78371,Q93008,P42167,P40227,P15924 Visual phototransduction -0.3905033580154521 -1.6456709637835334 0.0998315201810751 1.0 0.2614217312298803 19 O60551,P02656,P09455,P98164,P04114,O75911,P29374 Synthesis of dolichyl phosphate -0.6204516261150315 -1.643228331937968 0.1003357000620404 1.0 0.26228104051305295 5 Q86SQ9,Q9UPQ8,Q96E22 Nectin necl trans heterodimerization -0.609746839970022 -1.642200217160795 0.10054851771698403 1.0 0.2623770427290827 3 Q92692,P15151 Competing endogenous rnas cernas regulate pten translation -0.6494430414742633 -1.6373914042137343 0.10154871312549218 1.0 0.263672119208182 4 Q8NDV7,Q9UPQ9,Q9UL18 Regulation of pten mrna translation -0.6494430414742633 -1.6373914042137343 0.10154871312549218 1.0 0.263672119208182 4 Q8NDV7,Q9UPQ9,Q9UL18 Signaling by mst1 -0.5062927004674672 -1.637262167377966 0.10157570229899093 1.0 0.263672119208182 1 Q13043 Activated tak1 mediates p38 mapk activation -0.483382903845079 -1.6354283676589196 0.10195927969201968 1.0 0.26420752476714665 11 Q16644,P49137,Q13404,Q9Y6K9,P52564,P51617,P46734 Signaling by tgf beta receptor complex in cancer -0.607337479827449 -1.6291569453031842 0.10327979876526938 1.0 0.26716475722265864 3 Q13485,O95405 Arms mediated activation 0.5868195821578551 1.625308673189591 0.1040968043098216 1.0 0.26881150506349083 3 Branched chain amino acid catabolism 0.35018752856904284 1.6229644931779474 0.10459699537033851 1.0 0.26890539718405443 19 Q6NVY1,Q99714,P26440,Q96RQ3,P09622,Q02252,P24752,Q9HCC0,P30084 Ikba variant leads to eda id -0.5554675660147735 -1.6215980063706035 0.10488944981172921 1.0 0.26890539718405443 6 P19838,Q9Y6K9,O14920,Q00653,Q04206 Synthesis of epoxy eet and dihydroxyeicosatrienoic acids dhet -0.5037756202804841 -1.6210332109056054 0.10501051633508807 1.0 0.26890539718405443 1 P34913 Biosynthesis of maresins -0.5037756202804841 -1.6210332109056054 0.10501051633508807 1.0 0.26890539718405443 1 P34913 Transcriptional activation of mitochondrial biogenesis -0.34243004979162317 -1.6209165778615646 0.10503553098061724 1.0 0.26890539718405443 25 P11474,Q92793,O15379,Q16566,Q9H5Q4,Q9UHN1,Q9NTG7,P13196,P16220 Acyl chain remodelling of pe -0.6053956834532382 -1.618634718984063 0.10552588033781318 1.0 0.2692834076204928 3 Q9NP80,Q6P1A2,Q643R3 Glycogen metabolism 0.4237164471683481 1.618547598506592 0.1055446376176965 1.0 0.2692834076204928 13 P06737,P10253,Q96G03,P36871,Q16851,P11216 The role of nef in hiv 1 replication and disease pathogenesis 0.3865172766971284 1.616986864957288 0.10588111623986052 1.0 0.2696801080297302 16 P63010,O94973,Q9BXS5,P53680,Q10567,O43747,Q96CW1,P63000,P04439,Q13177,Q9UI12 Erythrocytes take up carbon dioxide and release oxygen -0.5028766630708472 -1.6152323707658316 0.10626038291651296 1.0 0.26972111263448145 1 Q9UHQ9 Esr mediated signaling -0.26330471277408807 -1.614961360769084 0.10631906270905978 1.0 0.26972111263448145 80 O60563,P52655,Q05513,P29353,Q9UPQ9,P05412,P16220,P14859,P01111,P62879,Q9HAV0,Q92993,Q8NDV7,Q9UL18,P52657,P00533,P01106,Q8N257,P08047,Q92793,Q09472,O43524,Q9Y243 Late endosomal microautophagy -0.3628512779050169 -1.61386773321931 0.10655611886063365 1.0 0.26972111263448145 21 Q96EY5,Q13099,Q9BY43,A5D8V6,Q99541,Q9UK41,Q9NZ09,O95613,Q9UBN7 Maturation of sars cov 1 spike protein 0.5889909563707731 1.6135673717656425 0.1066212988870534 1.0 0.26972111263448145 5 P27824,P14314,Q14697 Glutamate and glutamine metabolism 0.47550268027065046 1.6068115335245399 0.1080957174171635 1.0 0.2729874897484299 9 Q96C36,O94925,P00505,P54886,P32322,P04181 Synthesis of glycosylphosphatidylinositol gpi -0.6427415002698695 -1.6031454254577295 0.10890255103730784 1.0 0.2744612129451716 4 Q9Y2B2,Q8TEQ8,Q5H8A4,P37287 Nf kb is activated and signals survival -0.6126355092225292 -1.6012494772896266 0.10932167422904793 1.0 0.2744612129451716 5 P51617,P19838,Q04206,O14920 Regulated necrosis 0.28986633062021516 1.6010534570092494 0.10936507962502606 1.0 0.2744612129451716 28 Q16543,O75955,P04637,P09429,O15294,P07900,Q14254,Q8WUM4 Antigen presentation folding assembly and peptide loading of class i mhc 0.3111784921388191 1.6008232122121566 0.10941608086539056 1.0 0.2744612129451716 22 P27824,P51572,P30101,P10321,Q15436,P04439,P53992,O95486,P27797,O94979 Rhob gtpase cycle -0.2927918102984886 -1.5976436588797738 0.11012230419414548 1.0 0.275768459242482 46 B2RTY4,Q9NZN5,Q8WUY9,O94804,Q9NRY4,Q5T5U3,O15085,Q15836,Q9BST9,O15013,Q13459,Q12979,Q7Z628,P52735,O60245 Perk regulates gene expression 0.3589084975471849 1.5958357485315957 0.11052546962303267 1.0 0.2761885357564222 18 P20042,P08243,Q5RKV6,Q9Y2L1,Q92945,Q9NQT4,P05198,Q9NQT5,Q15024,O95453 Potassium channels -0.6110559055590087 -1.5927474417684415 0.11121686003614317 1.0 0.2761885357564222 5 Q9HAV0,P62873,P62879 Prostacyclin signalling through prostacyclin receptor -0.6110559055590087 -1.5927474417684415 0.11121686003614317 1.0 0.2761885357564222 5 Q9HAV0,P62873,P62879 Inwardly rectifying k channels -0.6110559055590087 -1.5927474417684415 0.11121686003614317 1.0 0.2761885357564222 5 Q9HAV0,P62873,P62879 Glucagon type ligand receptors -0.6110559055590087 -1.5927474417684415 0.11121686003614317 1.0 0.2761885357564222 5 Q9HAV0,P62873,P62879 Hiv transcription initiation -0.3236640906709868 -1.5890446897684412 0.11205030359314261 1.0 0.2774913631124262 30 Q9HBM6,P29084,P52655,Q12962,Q15545,Q15542,Q6P1X5,P51948,P52657,P61218,O00268,P50613 Pyruvate metabolism 0.33381456428930095 1.5887627760944651 0.11211396012998698 1.0 0.2774913631124262 20 P11177,P08559,Q04760,P09622,P21796,P00338,P53985,P07195,P10515,P35613 Adora2b mediated anti inflammatory cytokines production -0.3958096385817865 -1.5865699290389903 0.1126100825606795 1.0 0.27825708626104884 18 P16220,P31323,P62879,Q9HAV0,P22694,P31321,O60266 Dna damage bypass 0.2658499031377027 1.584399179764787 0.11310290846825644 1.0 0.2790121417511624 34 P40938,P27694,Q14258,P35251,Q13620,Q16531,P28340,P40937,Q07864,Q92890,P35250,P35249,P55072,Q9Y2S7,Q14694,Q8TAT6,P12004 Met activates ptpn11 0.5769784172662027 1.5739265962834088 0.11550442038731656 1.0 0.28446543202826724 3 Q06124,P62993 G beta gamma signalling through pi3kgamma -0.5002597916951084 -1.5676812001066518 0.11695555126706458 1.0 0.2874626986129977 9 P62873,P31749,P62879,Q9HAV0,Q9Y243 Synthesis of very long chain fatty acyl coas 0.4521999136216688 1.567031678090425 0.11710728728730846 1.0 0.2874626986129977 10 P33121,O95573,O60488,Q9P035,Q53GQ0 Fceri mediated ca 2 mobilization -0.484026639052336 -1.5630712094625456 0.11803584656519894 1.0 0.28895760896242545 10 Q14571,P16885,Q12968,P52735,P29353 Sumoylation of intracellular receptors -0.6054972467476607 -1.5627808488018418 0.11810415024034704 1.0 0.28895760896242545 5 P04150,O75928,O75925,Q8N2W9 Synthesis of pips at the plasma membrane -0.34254721245965947 -1.5607855295128756 0.11857436281654765 1.0 0.28963245999451803 23 Q8TCG2,Q9BT40,Q12923,O43426,Q13613,P48426,Q13496,P78356 Neurotransmitter receptors and postsynaptic signal transmission -0.2686175628977368 -1.5545610544828496 0.12005064518425801 1.0 0.2927585291727405 65 P24588,Q9NRD5,Q96RR4,Q9NUP9,Q9Y2X7,Q9Y478,Q16566,P01111,P62879,Q9HAV0,P68366,P31323,Q9BQE3,Q01970,P16220,P31321,P22694,O60266 Gpcr ligand binding -0.37954479908590794 -1.5471089533567133 0.12183697532905247 1.0 0.2966292373207323 19 P08174,Q9UK39,P62879,Q9HAV0,Q3ZCW2,P48960,P22466,Q9ULM6 Akt phosphorylates targets in the nucleus -0.6021705299045845 -1.5448116720981677 0.12239182318901554 1.0 0.29749399111196273 5 Q9Y243,O43524,P16220 Ngf stimulated transcription -0.5270943195613915 -1.5424376431137148 0.12296728002027768 1.0 0.2981578778601119 7 Q99963,Q09472,P18846,P16220 Fcgr activation -0.630829534154007 -1.5420346884621907 0.12306516435165693 1.0 0.2981578778601119 4 P12931,P06241 Apc c cdc20 mediated degradation of cyclin b 0.40016338894846964 1.5397172415396247 0.12362929224070318 1.0 0.29903838545235023 14 Q16763,P30260,Q9UJX4,Q9H1A4,P14635,P06493,Q9UJX3,Q9UJX2 Recycling of eif2 gdp 0.4807285516269256 1.5357148017602373 0.1246083431823708 1.0 0.3009180410725 8 Q14232,P20042,Q9NR50,P05198,Q13144 Retrograde neurotrophin signalling 0.44697422137193676 1.5338614041221577 0.12506375284700044 1.0 0.3011463885819434 10 Q00610,P63010,O95782,O94973,P53680,Q96CW1,P50570 Synthesis of pips at the early endosome membrane -0.45810248416026145 -1.53368517012928 0.12510712384712952 1.0 0.3011463885819434 12 Q8TCG2,Q8NEB9,Q9Y2I7,Q08AM6,Q13496,Q9NYA4,Q9C0I1 Interleukin 10 signaling -0.5895519401734062 -1.5324544748882811 0.12541032356325088 1.0 0.3013893259826513 3 P29597,P23458 Transferrin endocytosis and recycling 0.41060052513084566 1.5294338210474718 0.1261569334110999 1.0 0.301699771469726 13 P61421,P02786,P21283,Q15904,Q9UI12,Q93050,P38606,Q9Y487,P21281 Transport of connexons to the plasma membrane -0.4944009598548068 -1.5286586997279474 0.12634907585765132 1.0 0.301699771469726 9 P17302,P68366,Q9BQE3 Inhibition of the proteolytic activity of apc c required for the onset of anaphase by mitotic spindle checkpoint components 0.38664887732215086 1.5286572538097356 0.12634943449470404 1.0 0.301699771469726 15 Q16763,P30260,Q9UJX4,Q9H1A4,Q9UJX3,O60566,Q9UJX2,O43684 Apc cdc20 mediated degradation of nek2a 0.38664887732215086 1.5286572538097356 0.12634943449470404 1.0 0.301699771469726 15 Q16763,P30260,Q9UJX4,Q9H1A4,Q9UJX3,O60566,Q9UJX2,O43684 Slc mediated transmembrane transport -0.28861158366762535 -1.5277431043199854 0.12657633347865405 1.0 0.30175797901311124 45 Q8N697,P14672,Q9Y2D2,Q9ULF5,Q6NXT4,Q9NY64,Q8N8R3,Q8IWA5,Q92504,Q01650,P52569,Q6PCB8 P38mapk events -0.5229284198076144 -1.5164755900969724 0.1293991380470385 1.0 0.30799475349854216 7 P12931,Q16644,P49137,P01111,P11234 Activation of caspases through apoptosome mediated cleavage -0.6245733729155795 -1.5098223061595244 0.13108877167002242 1.0 0.3115187715922383 4 O14727,P55210,P98170 Transcriptional regulation by e2f6 -0.33968494539281646 -1.5028598754611644 0.1328751818521452 1.0 0.31526117987212793 22 Q06609,O14757,Q15910,Q09028,Q06587,P35226,Q969R5,O14727,O00311,Q9BYE7,Q9UBK9,Q8IWI9 Tp53 regulates transcription of genes involved in cytochrome c release -0.5050352529078247 -1.4986726616811343 0.13395857228066665 1.0 0.31720312251404575 8 Q658P3,Q07812,Q13625,Q92793,Q13315,Q13794,Q9Y255 Ksrp khsrp binds and destabilizes mrna 0.3702525836713495 1.4980531534113448 0.1341194410629858 1.0 0.31720312251404575 16 P63104,Q5RKV6,Q9Y2L1,Q92945,Q9NQT4,Q9NQT5,Q15024,O95453 Hiv life cycle 0.1676165256369268 1.4944817763713016 0.1350497415780023 1.0 0.3188971710795934 117 O75531,O00267,Q08945,P30876,Q99567,P46060,Q8N1F7,P24928,Q12769,Q8TEM1,Q8WUM4,P49792,Q8WUM0,P49790,P43487,P78406,P62487,O75475,Q9Y5B9,P57740,P62826,P35658,P39748,Q92621,P12956,Q9NRG9,Q7Z3B4,Q9BW27,Q9BTX1,P52948,P30419,O14980,P13010,P12270,P18754,O75694,Q9UKX7 Extra nuclear estrogen signaling -0.32053478448014433 -1.4855555903336015 0.1373967090747641 1.0 0.3239257856351242 28 P12931,P62873,Q05397,P08069,P31749,P01111,P62879,Q9HAV0,O43524,Q9Y243,P00533,P16220,Q05513,P29353 Alpha oxidation of phytanate 0.5635296356986582 1.483168871207589 0.13802954948138613 1.0 0.3249036788740368 5 P51648,O43808,Q9UJ83 Intra golgi and retrograde golgi to er traffic 0.15665682404201323 1.4798078754107995 0.13892452636246233 1.0 0.32649454933764804 141 Q9P2W9,Q9H0H5,Q15363,P43034,Q99661,Q9Y6G9,P46459,Q15042,Q13409,P52732,O00139,P40616,O15260,P47755,P61163,Q13190,Q92538,P18085,P33176,Q9H2M9,P53621,Q14203,P35606,P24390,O95235,Q9UJW0,P54920,O15498,P47756,Q9H0U4,P20645,Q13561,Q9Y678,P49755,P62820,Q13885,P53618,Q9BUF5,Q12981,P68371,Q15102,O75935,Q99747,O14579,P52907,Q96FJ2,Q6NUQ1,Q9BW19,Q8TD16,Q9BVK6,P61923,Q9UBF2,O95239,Q9Y3B3,P11717,Q5VIR6,O43264,O00461,Q8N6T3,Q12756,Q02241,Q9NP72,Q9NZ32,Q14807,P63167,O75396,Q9BVA1,Q07866,O43237,Q10472,Q10471,O60664,Q8IWJ2,Q16706,P04350,P48444,Q9UID3,Q8TBA6,Q14204 Shc1 events in egfr signaling -0.6171029243499944 -1.4712576165952176 0.14122146071644393 1.0 0.3313700416811046 4 P00533,P29353,P01111 N glycan trimming and elongation in the cis golgi -0.6166576722432383 -1.4689557683699552 0.14184478675327927 1.0 0.33155229018053317 4 Q5SRI9,P33908,O60476,P26572 Caspase activation via dependence receptors in the absence of ligand -0.6165906564444007 -1.4686092808093392 0.14193879612897708 1.0 0.33155229018053317 4 Q9Y5V3,O43293 Insertion of tail anchored proteins into the endoplasmic reticulum membrane 0.3899074986506532 1.4685065243305158 0.1419666853256243 1.0 0.33155229018053317 14 Q9P0L0,P09601,P50402,P46379,P51648,O43765,O43681 L1cam interactions 0.21078778325756592 1.466078326439491 0.1426269495219472 1.0 0.3322493642434182 59 Q96P70,P51812,P11142,P26038,P15311,P53680,P63000,Q96S59,Q9BVA1,Q02750,Q00610,O95782,Q9BUF5,P28482,Q96CW1,Q12955,P05556,Q13813,Q15418,P50570,Q16555,P35241,P09496,P67870,O95239,P19784,Q01082,P63010,O94973 G2 phase -0.5773285371063851 -1.465595426542281 0.1427585379607903 1.0 0.3322493642434182 3 O00716 Formation of tubulin folding intermediates by cct tric 0.36570914936339244 1.4649516027789986 0.1429341224698195 1.0 0.3322493642434182 16 P17987,Q99832,P40227,P48643,P50991,P50990 Circadian clock -0.33280811057494214 -1.4612990686985532 0.14393338534436761 1.0 0.3335472238245226 23 Q7Z5J4,P04150,Q92793,P36873,Q9Y297,Q09472,O15379,Q9UK39,Q9BZK7,Q96RS0,P49674,P16220 Estrogen stimulated signaling through prkcz -0.576414658336089 -1.4605847138130443 0.14412944381691184 1.0 0.3335472238245226 3 Q05513,P01111 Dna replication initiation 0.4680342550883579 1.4596982057463694 0.1443730352501964 1.0 0.3335472238245226 8 P09884,Q07864,P49642,Q9NR33,Q9NRF9,P49643 Runx2 regulates bone development -0.4479499673924464 -1.4593021710191063 0.14448195813547193 1.0 0.3335472238245226 12 Q9UPW6,P12931,Q13485,P46937,O15379,Q9UBN7 Synthesis of substrates in n glycan biosythesis -0.31200426602994547 -1.4588305592640582 0.14461174938969235 1.0 0.3335472238245226 30 A2VDF0,Q9UPQ8,O14772,Q9Y274,Q96E22,O15305,Q11206,O94808,Q99519,Q8TBE9,Q86SQ9 Activation of rac1 downstream of nmdars -0.5860101740341438 -1.4571680225078645 0.1450700052578271 1.0 0.3340870291099882 5 Q96RR4,Q9Y2X7 Trna processing 0.18474795199512978 1.4551843276145238 0.14561823848699484 1.0 0.334832060718553 88 Q99714,P37198,Q99567,Q8N1F7,Q12769,Q8TEM1,Q52LJ0,P49792,Q8WUM0,P49790,O15091,P78406,P33240,Q92499,Q9Y224,P07814,P57740,P62826,Q9Y3I0,P35658,Q92621,Q9BQ52,Q5SRE5,Q9NRG9,Q10570,Q99575,Q7Z3B4,Q9BW27,Q9BVL2,P52948,Q9BTX1,Q08J23,P78346,P12270,O75694,Q96EE3,O43592,Q8NFH4,Q7L0Y3,Q9UKX7 Arachidonic acid metabolism 0.4338200787216274 1.450452346207174 0.14693241880708352 1.0 0.33733328817034586 10 Q8N8N7,Q9H7Z7,P16152,Q15185,P09960,Q15165 Rho gtpases activate pkns 0.2798461865423598 1.4470249168974239 0.1478899450809219 1.0 0.33852760433756723 26 P63104,O60341,P60660,Q04917,P62805,P35580,P35579,P62258,P27348,P31946 Surfactant metabolism -0.5841353361250942 -1.4469639265304324 0.14790702713003778 1.0 0.33852760433756723 5 Q15361,Q92908,Q99758 Role of second messengers in netrin 1 signaling 0.5191282879810031 1.4441562823100877 0.148695019220614 1.0 0.33902441203781764 2 Prolonged erk activation events 0.4654247628780473 1.4440836026829424 0.14871545993176527 1.0 0.33902441203781764 8 P28482,P31946,P46109,Q02750 Fatty acyl coa biosynthesis 0.30449151858811097 1.4437593214466233 0.14880668823673338 1.0 0.33902441203781764 21 P33121,O95573,P53396,O60488,Q13085,P49327,Q9P035,P50897,Q53GQ0 Anti inflammatory response favouring leishmania parasite infection -0.31320326746583976 -1.438105300622645 0.1504041788970054 1.0 0.3421408039031116 29 Q14571,P06241,P31323,P62879,Q9HAV0,P16220,P31321,P22694,P16885,O60266 Shc1 events in erbb2 signaling -0.5239776782625896 -1.4316450099061004 0.1522454413506007 1.0 0.34580138355548024 6 P29353,P00533,P01111 Synthesis of active ubiquitin roles of e1 and e2 enzymes 0.39554383569081436 1.42744685912276 0.15345113224976314 1.0 0.3480094171265557 13 P68036,P45974,P22314,Q93008,Q93009,A0AVT1 Endosomal sorting complex required for transport escrt -0.33194314817951937 -1.4243416983891783 0.1543475822994036 1.0 0.3493642353548026 22 Q9H444,Q9UQN3,Q96EY5,Q9UK41,Q8WUX9,Q92783,O14964,Q9BRG1,A5D8V6,O75886,Q9NZ09,Q9Y3E7,O75351,Q9NZZ3,Q96FZ7,Q9H9H4,Q9BY43,O43633,Q9UN37,Q9NP79,Q86VN1 Ripk1 mediated regulated necrosis 0.37177001428696066 1.422974907410416 0.1547434294548009 1.0 0.3493642353548026 15 Q16543,O75955,O15294,P07900,Q14254,Q8WUM4 Respiratory electron transport atp synthesis by chemiosmotic coupling and heat production by uncoupling proteins 0.17422526013936598 1.4228486132251559 0.15478004539603396 1.0 0.3493642353548026 96 P06576,P21912,Q9UDW1,P36542,Q12931,P08574,Q16718,P38117,O14949,O43676,O75251,P51970,Q9Y6M9,O75964,O96000,P49821,Q9BQ95,O95182,P20674,Q16795,P00403,Q9H845,O43819,O75489,P13804,O75880,O95299,Q9P032,O95168,Q86Y39,P13073,P48047,P31040,P22695,P19404,P10606,P42704,P31930,P25705,P56134,O75306,P28331,Q16134,P56385,O00483,O75947,P24539 Rab gefs exchange gtp for gdp on rabs -0.2707802941197832 -1.4221372329656066 0.15498641581847283 1.0 0.3493642353548026 53 Q8WXG6,Q86VX9,P51159,P20336,A5PLN9,Q6ZUT9,Q96QF0,Q9Y5R8,Q9UL33,Q9Y243,Q8IWF6,Q86SZ2,P26374,Q8WVT3,Q9NRW1 Regulation of insulin secretion -0.3232626844256919 -1.4203981109543657 0.15549181246105315 1.0 0.34970094741070307 25 Q14571,P24588,P50148,P31323,P62879,Q9HAV0,Q01970,P22694,P31321 Myoclonic epilepsy of lafora 0.5148354612479649 1.420008568050469 0.1556051866666417 1.0 0.34970094741070307 2 P13807 Fructose metabolism 0.5471473322454299 1.417815830722051 0.15624454105533392 1.0 0.3506089851994692 3 P15121 Integration of provirus 0.4608914641799812 1.4169731921796025 0.1564907654189387 1.0 0.3506334443221333 8 O75531,P52294,P12956,O75475,P13010 Nade modulates death signalling 0.546620760645493 1.415058498092215 0.15705134516408803 1.0 0.35136111755929605 3 Rhod gtpase cycle 0.23313345663675553 1.4115707782865383 0.15807638163314608 1.0 0.35312415087464416 41 Q9BX68,Q9UEY8,P49257,P20700,O95292,Q14739,O15173,Q9H0H5,Q9NSV4,Q9BSJ8,Q02952,Q9Y2U8,Q5JTV8,P50402,P51149,P42167,Q9P2R3,Q68EM7,P12814,O60610,P47756,P42166,Q16643 Glutathione conjugation 0.3344106498942595 1.4076371656395312 0.15923853642022778 1.0 0.35518775339242425 18 Q96KP4,O14880,P14550,Q8WUX2,O43708,P48637,P21266,P10768,P78417,O75223,Q99735,P28161,P48507,Q9Y2Q3 Dual incision in tc ner 0.22031837018741232 1.4031070674521633 0.16058491398725128 1.0 0.3576554885515761 49 P40938,Q13620,P30876,P24928,Q07864,P35249,P19387,P23193,O60306,P15927,Q16531,P62487,P28340,P35250,P12004,P40937,P18074,Q9HCS7,P41440,Q9Y2S7,P35251,P19447,Q9UMS4,Q93009,P27694,P19388 Pka activation in glucagon signalling -0.49017604731749237 -1.402292793557856 0.16082783149598257 1.0 0.3576618939239015 8 P31321,O60266,P22694 Potential therapeutics for sars 0.21046690531973697 1.401439687408128 0.16108263130676725 1.0 0.3576946656439392 54 P21964,P54709,O60341,P07437,Q92769,O00422,Q96CW1,Q02790,Q14839,P05556,Q86YP4,P08238,O94776,P07900,P63010,P05023,O94973,Q15185,Q9NZI8,P12268,Q13618 Metabolism of fat soluble vitamins -0.43954732522799767 -1.397370342021522 0.1623022329199313 1.0 0.3598665581111572 12 P02656,P09455,P98164,P04114,Q9Y5Z9,P29374 Hiv elongation arrest and recovery 0.27058519491868893 1.3954552624937138 0.162878596608381 1.0 0.36027106420151733 27 Q15370,Q8IXH7,O00267,P35269,Q08945,P30876,P62487,Q9Y5B9,O15514,P23193,P24928,P18615,Q9H3P2,P19387,Q14241,P19388,Q8WX92,P62875 Infection with mycobacterium tuberculosis 0.35595670335106383 1.3941737952546585 0.1632651290912024 1.0 0.36027106420151733 16 P52294,P28482,P20339,P00558,P23246,P51149,Q9UI12,P06733,Q14974 Response of mtb to phagocytosis 0.35595670335106383 1.3941737952546585 0.1632651290912024 1.0 0.36027106420151733 16 P52294,P28482,P20339,P00558,P23246,P51149,Q9UI12,P06733,Q14974 Hcmv infection 0.1847386160638571 1.393555618566731 0.16345183852364142 1.0 0.36027106420151733 80 Q99567,Q8N1F7,Q12769,Q8TEM1,Q8WUM0,P49792,P49790,Q9BUF5,P78406,P62805,P57740,Q15022,Q9Y6G9,P05556,P35658,Q92621,P83916,Q5SRE5,Q9NRG9,Q7Z3B4,Q9BW27,Q9BTX1,P52948,Q99816,Q13263,P61978,P12270,O75694,Q8NFH4,Q14204,Q9UKX7 Glycogen breakdown glycogenolysis 0.4391677581216724 1.3831273743458925 0.1666258134109575 1.0 0.36672446378482526 9 Q96G03,P06737,P11216,P10253 Signaling by nodal -0.5152650846042901 -1.3786100148181288 0.16801502709259886 1.0 0.36885949380280825 6 Q13485,Q14919,O43524,P36896 Notch3 intracellular domain regulates transcription -0.5009074903188044 -1.3783637674031035 0.16809100422289047 1.0 0.36885949380280825 7 Q92793,Q92830,Q09472 Signalling to ras -0.4717916505095721 -1.3768596804841242 0.16855563496899362 1.0 0.3693351413291184 9 P12931,Q16644,P49137,P01111,P11234,P29353 Rho gtpase effectors 0.10597125515755716 1.3758978372662474 0.1688532649082073 1.0 0.3694440010473258 182 P61586,P21333,P53350,O60341,P60660,Q14008,P46060,P35579,Q9HBM1,P49792,P60953,Q16513,P43034,Q9Y2A7,P57740,Q99661,P46940,Q9Y6G9,Q9P258,P16104,Q86UP2,Q9BW27,P62993,Q13409,P52948,O60610,Q15334,O00139,O14980,O43663,Q15691,Q8NFH3,P30153,Q9Y266,P33176,Q12769,Q14738,Q99570,P62258,Q9NSV4,Q15005,P31946,Q13576,P28482,Q04917,P27348,P05556,P35580,O15144,Q9UQB8,O43684,P30154,P63000,Q13464,Q13885,Q8WUM0,P50748,P62140,Q9BUF5,P68371,O15145,Q7L576,P62805,P35080,Q13177,Q96FJ2,Q53HL2,Q92747,O43264,Q96EE3,P27361,P61158,P35221,Q8WYP5,P61160,P63167,Q9BVA1,P84095,Q07866,P07737,P23528,O43237,Q7Z406,Q2NKX8,Q16539,O75116,P63104,P61981,P59998,P04350,O60566,Q7Z460,Q14247,P35222,Q9NQS7,Q8NFH4,Q9HD26,Q13526,Q14204 Protein folding 0.2103397370100126 1.372196413781518 0.1700023015332759 1.0 0.3709413639261487 53 P17987,Q99832,P36404,Q9Y2T2,P48643,O75347,Q15477,Q9BUF5,P78371,Q9UHV9,O00567,P50990,P61758,Q15813,P40227,P50991,P67870,Q9BTW9,P49368,Q9H0D6,P04637,P04062 Abortive elongation of hiv 1 transcript in the absence of tat 0.31831244537871567 1.3714051616930907 0.170248689300051 1.0 0.3709413639261487 19 Q8IXH7,O00267,P62487,P30876,O15514,P24928,P18615,Q9H3P2,P19387,P19388,Q8WX92,Q09161,P62875 O linked glycosylation -0.43602175428223205 -1.371290256310075 0.17028449189629913 1.0 0.3709413639261487 12 Q9UHI8,Q9H5K3,Q11206,Q9NY97,Q8NAT1,Q9Y2G5,Q14118 Vldlr internalisation and degradation 0.4530055721018314 1.369876948180006 0.17072531666297275 1.0 0.37135871799683123 8 Q00610,P63010,O95782,O94973,P53680,Q96CW1 N glycan trimming in the er and calnexin calreticulin cycle 0.28420731821425876 1.3684025966534104 0.17118609191319023 1.0 0.3718181879747135 22 P27824,Q9NYU2,P62191,Q13724,P30101,Q14697,P55072,P54727,P27797,P14314 Vegfr2 mediated cell proliferation -0.455831393443948 -1.3670823143193782 0.17159950606544006 1.0 0.3719856203740656 10 Q14571,P12931,P01111,P20936,P17252,Q05513,P05771 Degradation of the extracellular matrix -0.3597588500504198 -1.3665624690618687 0.17176248779688397 1.0 0.3719856203740656 19 Q9UHI8,P14543,Q13443,Q9Y6W3,P49768,P07711 Signaling by ctnnb1 phospho site mutants 0.4359963274813363 1.3636776135381712 0.17266905275200184 1.0 0.3728650559427286 9 P35222,Q14738,P48729,P30153 Beta catenin phosphorylation cascade 0.4359963274813363 1.3636776135381712 0.17266905275200184 1.0 0.3728650559427286 9 P35222,Q14738,P48729,P30153 Aberrant regulation of mitotic exit in cancer due to rb1 defects 0.3857694159352851 1.3615706391622355 0.17333342645926897 1.0 0.3737580396878593 13 Q16763,P30260,Q9UJX4,Q13309,Q9H1A4,Q9UJX3,Q9UJX2 Sensory perception -0.27681118277341366 -1.3592216771292642 0.17407635421801437 1.0 0.3748175835041061 44 P08247,O60551,P02656,P20336,Q12929,O75911,Q9H2D6,P29374,O60266 Diseases of glycosylation -0.2786864369766805 -1.3563627501672797 0.1749837790493518 1.0 0.3762277500483899 42 Q9BVK2,Q14376,O15305,Q9Y672,Q86SQ9,Q04721,Q9H3H5,Q99519,Q9UKM7,Q9NP73,Q9UHI8,Q96AA3,O95340,Q96E22,O94766,Q96F25,Q10469,Q9H553,Q9UPQ8,Q9H6U8,Q93063,P15291,Q14118 Robo receptors bind akap5 -0.5664262754257269 -1.3502455732678125 0.1769372242159104 1.0 0.37949095006169775 5 P24588,P22694 Oncogene induced senescence -0.4228677761366639 -1.349956112254885 0.17703006101703167 1.0 0.37949095006169775 13 P08047,Q9UPQ9,Q8NDV7,O00716,Q9UL18 Recognition of dna damage by pcna containing replication complex 0.2687091729304712 1.349222308633857 0.17726557130398768 1.0 0.37949095006169775 26 P27694,P35251,Q13620,Q16531,P28340,P40937,Q07864,P35249,Q9Y2S7,P35250,P12004 Transcriptional regulation by the ap 2 tfap2 family of transcription factors -0.4225443691078883 -1.3474865836415646 0.17782357152693629 1.0 0.38013934228857255 13 Q96SI1,Q92793,Q09472,P00533,P01106,Q9UGL1 Notch3 activation and transmission of signal to the nucleus -0.49564828058008614 -1.3451793704819686 0.1785673165281756 1.0 0.38118238055441495 7 O00308,Q86YT6,P49768,P00533 Fatty acid metabolism 0.1752777148626378 1.3435336325523386 0.17909924322340665 1.0 0.3813626167247627 85 P11310,O75521,Q8N8N7,Q13085,P05165,P16152,P49327,O00763,Q9Y305,P50897,Q16836,O95864,P30084,Q4G176,P53396,O43808,O60488,P55084,Q9NZ01,P09110,Q15165,P40939,P49748,O95573,Q9NPJ3,P50416,Q9BY49,Q14914,Q9UJ83,Q15067,P05166,P42126,P23786,Q53GQ0,P22033,P51659,P42765,P33121,O43772,Q9H7Z7,O00767,P53007,P22307,Q15185,P09960,Q9P035,P51648,O00154 Rsk activation 0.5641302392516634 1.3429289019245767 0.17929499680989425 1.0 0.3813626167247627 4 P51812,P28482,Q15418 Transcriptional activity of smad2 smad3 smad4 heterotrimer -0.3571526484791373 -1.34254424793833 0.1794195935060796 1.0 0.3813626167247627 19 O00255,O60563,P08047,Q13485,P28749,P24863,P49336,P01106 Transport to the golgi and subsequent modification 0.14778552119600247 1.340265616488804 0.18015900569001309 1.0 0.382388772760854 118 Q08379,P49257,Q9Y678,O95487,P49755,Q15436,Q5H9R7,P63167,O75396,Q9BVA1,P62820,O95486,O00743,Q13885,Q9HCU5,O60763,P53618,Q9BUF5,P68371,Q15363,Q5JRA6,P53621,O75935,Q14789,Q12955,Q99747,Q9Y296,O14579,Q9Y6G9,Q92734,P46459,Q13813,P52907,Q12907,O94979,Q96FJ2,Q8WVM8,Q14203,P35606,Q8IUR0,P24390,Q9BVK6,P61923,Q9UBF2,Q96PC5,Q9UJW0,Q13409,P48444,P54920,O15498,Q01082,Q9Y3B3,P47755,P47756,Q9H0U4,Q9Y6Y8,P61163,Q13190,Q92538,P53992,Q8N6T3,P18085,Q14204,Q13561,O15027,P04066 Deadenylation of mrna 0.28073165011461976 1.3389386068329223 0.18059066002076563 1.0 0.38268966887782807 22 Q04637,Q92600,P06730,Q9HBH5,P23588,A5YKK6,Q9UIV1,Q14240,P60842,P11940,P38919,O95453 Chylomicron assembly -0.5914819482965631 -1.3382515569312687 0.18081444757717513 1.0 0.38268966887782807 4 P02656,P04114 Nuclear receptor transcription pathway -0.480059222888622 -1.3362817156125208 0.18145721054160102 1.0 0.38350531022267453 8 P04150,P11474,Q86WQ0,P10589,P28702 Positive epigenetic regulation of rrna expression 0.22350048793454638 1.3345693228264128 0.18201734398431224 1.0 0.3841442528847383 42 Q86YP4,O00159,P35659,O60264,Q9NY93,Q9BQG0,Q13185,O75533,P62805,O94776,Q9UIG0,Q14839,Q13330,O95602,Q9H9Y6,Q92769,Q9NR30 Synthesis of pi 0.49919079302282476 1.332011610678555 0.18285637323584036 1.0 0.38536916000198324 2 O14735 Glyoxylate metabolism and glycine degradation 0.3356205208038485 1.3302292748912425 0.183442741457027 1.0 0.38605887679515566 17 P11177,P36957,P08559,P00505,P09622,P30038,Q9UBQ7,P11182,P10515,Q02218,P23378 Signaling by tgf beta receptor complex -0.28020994985386993 -1.3262205560715774 0.18476665233151168 1.0 0.38829663183914304 38 O00255,O60563,P08047,Q13485,P28749,P36873,P24863,Q9NYA4,O95405,P49336,Q6ZSZ5,Q9P2M7,Q05513,P01106 Regulation of tp53 activity -0.23533007403694414 -1.322939418278907 0.18585552527538707 1.0 0.3895608320810526 101 P68400,Q9H9A7,Q9ULD4,Q12873,Q96S44,Q9H160,Q9NRG4,Q15542,Q99728,Q13315,Q9BX63,P78356,Q9NPI1,Q6P1X5,Q9HAF1,P29590,P31749,Q6R327,O60671,Q99638,P55201,P49848,Q8IW41,Q9HBM6,Q92794,Q12962,Q13362,Q92993,Q13472,Q13535,Q14191,Q8N0Z6,Q8WYH8,Q13625,Q9Y478,Q8WXE1,Q09472,P48426,Q15545,Q9Y243,P52564,Q8N9N5,O00268 Mrna editing 0.49755794070336046 1.3228324343952567 0.18589110846283785 1.0 0.3895608320810526 2 Signaling by erythropoietin -0.4777322183666433 -1.321057443119576 0.18648221148566746 1.0 0.38999998649118633 8 P29353,P16885,P01111,P51692 Synthesis of pips at the late endosome membrane -0.47766719580702743 -1.3206318290206716 0.18662415460954085 1.0 0.38999998649118633 8 Q8NEB9,Q9Y2I7,Q08AM6,Q13496,Q9NYA4 Rhoh gtpase cycle 0.2517400042821349 1.3196429061592219 0.18695427046666402 1.0 0.390142665259565 30 P52565,P55072,Q13464,Q16512,Q9UNZ2,Q9Y6M7,P51149,Q15758,P14923,Q13177,Q6IAA8,Q99707,O75116,Q8WWQ0,P02786,P41240,P11182,Q9BXB4,Q16643 Platelet adhesion to exposed collagen -0.5871071369996964 -1.3154400717962933 0.18836204561245573 1.0 0.39253069645113153 4 P06241,P17301 Collagen formation 0.3333088745578015 1.3132330631918205 0.1891044260223893 1.0 0.3929901814982262 17 O60568,P07237,P23284,Q15149,O15460,Q02809,O75718,P13674,O00469,Q8NBJ5,Q32P28,P50454 Formyl peptide receptors bind formyl peptides and many other ligands 0.5271582733813156 1.3132163967987283 0.1891100403585424 1.0 0.3929901814982262 3 Q9NRV9,P04083 Regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps 0.26093000983552916 1.3107873371130911 0.18992962188470996 1.0 0.39380725303531305 27 P07237,Q13217,Q5JRA6,P14625,Q9BTY2,Q15293,Q07065,Q15084,Q86UP2,Q02818,P14314 Cooperation of pdcl phlp1 and tric cct in g protein beta folding 0.31046683848442735 1.3104849800259688 0.1900318221022752 1.0 0.39380725303531305 19 P17987,Q99832,P40227,P48643,P50991,P50990 Antigen activates b cell receptor bcr leading to generation of second messengers -0.4759027887012398 -1.309078417618274 0.19050778916454125 1.0 0.3942452859099534 8 Q14571,P06241,Q13586,P16885,P16333 Translesion synthesis by polk 0.39998220264075085 1.3072684123656721 0.19112156816475712 1.0 0.3949669023099696 11 P40938,P27694,P35251,P15927,P40937,P35249,P35250,P12004 Creb1 phosphorylation through the activation of adenylate cyclase -0.475237807692702 -1.3047219958981748 0.1919875287936088 1.0 0.3962069500034309 8 P31321,P22694,P31323,P16220 Tp53 regulates transcription of death receptors and ligands 0.5251113023830085 1.3025196577199616 0.19273880250046993 1.0 0.3965067175905588 3 P04637 Atf4 activates genes in response to endoplasmic reticulum stress 0.3539045018955046 1.2972956271758591 0.19452948840093232 1.0 0.3965067175905588 15 P08243,Q5RKV6,Q9Y2L1,Q92945,Q9NQT4,Q9NQT5,Q15024,O95453 Processing of intronless pre mrnas 0.286651329265746 1.2966386017414304 0.19475556402031557 1.0 0.3965067175905588 21 O43809,Q6UN15,Q12996,Q10570,Q8N684,P33240,Q05048,Q92797,P51003,Q9UKF6,Q86U42,Q09161 Hdl assembly -0.5466465260819746 -1.2965904198375338 0.1947721504946709 1.0 0.3965067175905588 3 P22694 Pka mediated phosphorylation of key metabolic factors -0.5466465260819746 -1.2965904198375338 0.1947721504946709 1.0 0.3965067175905588 3 P22694 Foxo mediated transcription -0.3302775134692136 -1.295168519401128 0.1952621020384706 1.0 0.3965067175905588 21 Q92793,Q09472,O43524,Q9Y243,Q9NTG7,P25208,P31947 Tnfr1 induced proapoptotic signaling -0.5015262766093226 -1.2946261400811867 0.19544923038328 1.0 0.3965067175905588 6 Q13158,Q13107,Q14790 Activated ntrk2 signals through ras -0.5462164906986879 -1.294211892955142 0.19559223988527563 1.0 0.3965067175905588 3 P01111,P29353 Activated ntrk3 signals through ras -0.5462164906986879 -1.294211892955142 0.19559223988527563 1.0 0.3965067175905588 3 P01111,P29353 Shc1 events in erbb4 signaling -0.5462164906986879 -1.294211892955142 0.19559223988527563 1.0 0.3965067175905588 3 P01111,P29353 Shc mediated cascade fgfr4 -0.5462164906986879 -1.294211892955142 0.19559223988527563 1.0 0.3965067175905588 3 P01111,P29353 Shc mediated cascade fgfr1 -0.5462164906986879 -1.294211892955142 0.19559223988527563 1.0 0.3965067175905588 3 P01111,P29353 Shc mediated cascade fgfr3 -0.5462164906986879 -1.294211892955142 0.19559223988527563 1.0 0.3965067175905588 3 P01111,P29353 Processive synthesis on the lagging strand 0.34179237020703734 1.2922943226101544 0.19625523735140105 1.0 0.39731019518150484 16 P09884,P15927,P28340,P49643,P27694,P49642,P39748,P12004,Q9Y2S7 Interferon gamma signaling -0.3105153849060616 -1.2846591729112657 0.19891141105927668 1.0 0.4021411159814413 25 P13747,P23458,P29590,Q9Y6K5,P30511,Q9UPQ4,P17706,O75382 Nucleotide excision repair 0.17082134445483976 1.2832220062778594 0.1994143082831581 1.0 0.40229525401906796 82 P40938,Q13620,P18858,P30876,O96019,P24928,Q86WJ1,Q07864,P19387,P35249,Q7L5N1,P09874,O60306,P15927,Q16531,P62487,P28340,P19388,Q9Y265,P35250,P12004,Q9UNS2,P61201,P18887,P40937,P18074,Q9HCS7,P61088,P54727,Q9Y2S7,P41440,Q9BT78,Q13098,P35251,P19447,P49916,Q9UMS4,Q93009,Q92905,Q99627,P27694,P23193 Gpvi mediated activation cascade -0.4340400021931582 -1.282898478099437 0.1995276461208666 1.0 0.40229525401906796 11 P16885,Q05513,P06241,P52735 Estrogen dependent gene expression -0.26437799675684165 -1.2809315713194587 0.20021770236744807 1.0 0.40314104936148326 51 Q8N257,O60563,P08047,Q9UPQ9,P14859,Q92793,P05412,P52655,Q09472,Q8NDV7,Q92993,Q9UL18,P52657,P01106 Piwi interacting rna pirna biogenesis 0.38464360185168583 1.2799237675752848 0.20057194776893716 1.0 0.40330931467708014 12 Q9Y2W6,P62487,P30876,P07900,P24928,P19387,P19388 Nrif signals cell death from the nucleus -0.5787508105166508 -1.2718002873721774 0.20344408684791793 1.0 0.4085332741285684 4 P49768,P45983 Activation of kainate receptors upon glutamate binding -0.4557272619320118 -1.2679648237514887 0.20481051273572382 1.0 0.4107236392681406 9 Q92796,P62873,P62879,Q9HAV0,Q01970,Q12959 Defective intrinsic pathway for apoptosis 0.30451150674956506 1.2646468707140144 0.20599794321640585 1.0 0.4125496443446838 19 Q08379,P32119,P20810,P04179,P04637,P17655,Q00535,P02545,P20700,P62258,P07384,Q07021 Biotin transport and metabolism 0.40399119687581686 1.2625782713227205 0.20674078079867986 1.0 0.4134815615973597 10 P11498,Q13085,Q96RQ3,P05165,P05166,Q9HCC0 Sars cov infections 0.15525643538360664 1.2597153785628792 0.20777205565360957 1.0 0.4149870816673971 95 P21964,P54709,Q99873,Q13618,O60341,P39656,Q96SB4,P07437,P17844,O00422,P55072,P27824,P04843,Q96CW1,Q13724,Q02790,Q14839,P05556,P14314,Q86YP4,P46977,P08238,O94776,P07900,Q14697,P63010,P05023,O94973,P04844,Q15185,Q9NZI8,P12268,Q92769 Response to elevated platelet cytosolic ca2 0.2047512583842302 1.2576266506584493 0.20852681042737964 1.0 0.4159370114281067 49 P21333,P18206,Q9UNF1,Q08380,Q01518,P07737,P23528,Q9NZJ7,Q9Y490,P04075,Q8NBX0,O43707,O75083,P12814,Q9BWS9,O00186,Q9NTK5,Q9NUQ9,P37802 Oas antiviral response 0.5461143551910415 1.2550831025658575 0.20944859384169368 1.0 0.41721711874882833 4 P61221,Q6L8Q7 Rho gtpases activate wasps and waves 0.25737012384537955 1.251638518666004 0.2107016122687977 1.0 0.4191527400273813 26 P60953,P28482,O15145,Q7L576,P61160,Q9Y2A7,O15144,P63000,Q9UQB8,P59998,P62993,P61158 Adherens junctions interactions 0.4166685397976217 1.2457286791951547 0.21286402102395274 1.0 0.4214716387902156 9 P35222,P14923,P55196,P35221 Copii mediated vesicle transport 0.21071795545598068 1.2455368118909786 0.21293449279287668 1.0 0.4214716387902156 44 Q08379,P49257,O95487,P49755,Q15436,Q5H9R7,O75396,P62820,O95486,O00743,Q9HCU5,O60763,Q15363,Q99747,Q9Y296,Q92734,P46459,Q12907,O94979,Q8WVM8,Q8IUR0,P54920,O15498,Q9H0U4,Q9Y6Y8,Q13190,P53992,O15027 Urea cycle -0.5373765863026064 -1.2452735803190125 0.21303120365693706 1.0 0.4214716387902156 3 P00966 G protein beta gamma signalling -0.4091833235512151 -1.245061850378599 0.2131090159109481 1.0 0.4214716387902156 13 P62873,P31749,P62879,Q9HAV0,Q9Y243,Q01970,Q13153 Grb2 events in erbb2 signaling -0.53725363833472 -1.2445923841911906 0.21328162124014938 1.0 0.4214716387902156 3 P01111,P00533 Activation of nmda receptors and postsynaptic events -0.2680535333338347 -1.243646963278632 0.21362952365554255 1.0 0.42159998708179924 44 Q96RR4,Q9NUP9,Q9Y2X7,Q9Y478,Q16566,P01111,P31323,Q9BQE3,P68366,P16220,P31321,P22694 Rna polymerase ii transcribes snrna genes -0.2552192637257906 -1.2420274347948816 0.21422643994307378 1.0 0.4222187771364814 54 O94913,O60563,Q96CB8,P52655,Q15542,P61218,P29084,Q7Z7C8,Q9H0H0,P49848,Q9NVR2,Q8IXW5,Q659A1,P14859,P52657,Q9UL03,Q9Y2F5,P08047,Q6P9B9,O75909,Q8N5P1,Q9NP77,P52298,P50613 Transport of vitamins nucleosides and related molecules 0.38938113195633456 1.2396000325993715 0.2151233686039622 1.0 0.42307374877127396 11 Q6P1M0,P12235,Q8TB61,P05141,P12236 Mitochondrial translation 0.16540793931884407 1.2393170097347377 0.215228121858138 1.0 0.42307374877127396 82 P51398,P82650,Q9Y2R9,P09001,P82933,P49411,Q7Z2W9,P82673,O75616,Q9NP92,Q92665,Q96RP9,Q9H2W6,P49406,Q96EY7,Q9Y3B7,Q8TAE8,Q7Z7H8,Q9Y399,Q9BZE1,Q9BRJ2,P43897,Q9BYD2,P82675,Q6P1L8,P82930,P82663,Q9P015,Q9H9J2,Q92552,Q9Y3D9,Q9NYK5,Q9BYD6,P52815 Runx1 regulates estrogen receptor mediated transcription -0.4993706167955531 -1.2342125749306088 0.21712370283913862 1.0 0.4262375721084539 2 Q13951,Q9HCL2 Cobalamin cbl vitamin b12 transport and metabolism -0.4169245882409153 -1.229134374019752 0.21902142912229694 1.0 0.42939727551608214 12 Q9H3L0,Q9Y4U1,P35030,Q8IVH4,O14678,Q9NUN5,Q9UBK8,Q9NPF0 Intraflagellar transport -0.3051395951935722 -1.226879642341152 0.21986783110550867 1.0 0.4304488430134244 25 Q8TCX1,Q92845,Q13099,Q9Y366,Q8WYA0,Q9BQE3,Q9P2L0,P68366,Q15643,Q9Y547 Hsf1 dependent transactivation 0.2779287548678668 1.2261095432271807 0.2201574550657588 1.0 0.4304488430134244 21 P42345,P11142,Q92598,P08238,P0DMV9,Q02790,P07900,P25685,P50454 Regulation of runx1 expression and activity -0.44947691984759824 -1.2254001919760726 0.22042447464378712 1.0 0.4304488430134244 9 Q8NDV7,P29590,Q9UPQ9,Q9UL18 Thrombin signalling through proteinase activated receptors pars -0.4063540699370427 -1.223279093793746 0.2212243006441028 1.0 0.43144529837658796 13 P32121,P12931,P50148,P62873,P62879,Q9HAV0,P49407 Arachidonate production from dag 0.5095323741007367 1.2212758360160254 0.22198159926311112 1.0 0.4319488107352317 3 Q9BV23,Q8N2K0 Runx1 regulates expression of components of tight junctions 0.5092479767258087 1.2197960993701502 0.2225421804485892 1.0 0.4319488107352317 3 Metabolism of steroids 0.17447854177882705 1.2194127972814879 0.22268755515142002 1.0 0.4319488107352317 70 P48449,Q13085,Q15392,P49327,Q15436,P14324,Q9BWD1,Q14739,O95486,P38435,Q8NBQ5,Q96SU4,P37268,P62826,Q9UBM7,Q86X55,P22059,Q01581,Q15738,Q53GQ0,P22570,P51659,Q16850,P15121,O00767,P22307,P53992,P04062,Q13907,Q14974 Regulation of cholesterol biosynthesis by srebp srebf 0.2194981632819211 1.2183506749608162 0.2230907406303575 1.0 0.4319488107352317 36 Q16850,P48449,Q9UBM7,Q13085,P37268,Q01581,P49327,Q15436,P14324,P53992,P62826,Q14974,Q13907 Trif mediated programmed cell death -0.5324282996052165 -1.2178474221997349 0.22328195947534102 1.0 0.4319488107352317 3 Q13158,Q14790 Tlr3 mediated ticam1 dependent programmed cell death -0.5324282996052165 -1.2178474221997349 0.22328195947534102 1.0 0.4319488107352317 3 Q13158,Q14790 Golgi associated vesicle biogenesis 0.2075382811105461 1.2172430184966174 0.22351176716568033 1.0 0.4319488107352317 44 P11142,Q01968,Q8NBS9,P51148,Q00610,Q14677,Q10567,Q14789,P50570,Q9Y5X1,O43747,O60749,P09496,O14976,O00203,P54920,Q13492,P51809,P02786,O75976,Q9BXS5,P11717,O00443,Q9Y5X3,Q9H3P7 Formation of tc ner pre incision complex 0.21491500071370587 1.2156436241567952 0.22412070843212617 1.0 0.432564579745943 39 Q13620,P30876,P24928,P19387,Q7L5N1,P23193,O60306,Q16531,P62487,Q9UNS2,P61201,P18074,Q9HCS7,Q9BT78,P62875,Q13098,P19447,Q9UMS4,Q93009,Q92905,Q99627,P19388 Diseases of dna repair -0.3084231967132258 -1.2077035529796456 0.22716131089420655 1.0 0.43786591621263615 23 P40692,P54278,Q06609,Q9H9A7,O43502,Q96B01,Q92993,Q9BX63,Q13315,Q99728,Q13472,Q14191 Protein ubiquitination 0.2160590538733433 1.2003551694268115 0.23000143193724853 1.0 0.4427676144528428 37 P68036,P45974,P61086,Q6P1J9,O75150,P78527,P22314,O75381,Q93008,Q14527,Q93009,P04439,Q9BUN8,P55072,Q8N7H5,A0AVT1,Q9GZS3,P12004 Rac1 gtpase cycle -0.2370206325084351 -1.1972303653029737 0.2312167774104994 1.0 0.4445329010859924 81 Q9UH65,Q8WUY9,Q9UHR4,Q96P48,O15085,Q5T5U3,Q9NYB9,Q92558,O15013,Q6ZSZ5,P52735,O75044,A1A4S6,Q15836,Q8IWW6,Q9H2K8 Phosphate bond hydrolysis by nudt proteins 0.5339674705502138 1.1961155048434657 0.23165148784455702 1.0 0.4447947382582345 4 P36639 Mapk targets nuclear events mediated by map kinases -0.3620356544523109 -1.1937789099529343 0.23256446358047733 1.0 0.4459730382688691 17 Q13164,P45983,P49137,P45984,P05412,P18846,P16220 Attachment of gpi anchor to upar 0.5066570708888337 1.1927865994454885 0.2329529595783475 1.0 0.44614384289426445 5 O43292,Q92643,Q96S52,Q969N2 Peptide hormone metabolism -0.28853653660867484 -1.1911009842257292 0.2336139435477036 1.0 0.44683539908354086 30 Q9BY50,Q99626,P26367,O60282,P16870,Q9BYF1,Q9UBR2,Q86YB8,Q3ZCW2,Q6NXT4,P51159 Tgf beta receptor signaling in emt epithelial to mesenchymal transition -0.4708597726072167 -1.1879381709061219 0.23485776981760687 1.0 0.44863856029260796 7 Q05513,Q6ZSZ5,Q9P2M7 Cargo concentration in the er 0.2833779124709617 1.1849974903505833 0.23601843917825494 1.0 0.44989805250950315 20 Q9HCU5,Q15363,P49257,Q5JRA6,P49755,O95487,Q13190,Q15436,Q96PC5,P53992,O75396,O95486,Q12907 Trafficking and processing of endosomal tlr -0.5363264976624139 -1.1847381558928471 0.2361209913170681 1.0 0.44989805250950315 5 P07711,Q9H1C4 Establishment of sister chromatid cohesion 0.3912169113755237 1.1831379597157778 0.236754475821515 1.0 0.4505289514355777 10 Q29RF7,Q8N3U4,O60216,Q9NTI5,Q9UQE7,Q14683 Respiratory electron transport 0.15772296149804457 1.1821178572446116 0.23715893978473557 1.0 0.45072298505007147 82 P21912,Q9UDW1,Q12931,P08574,Q16718,P38117,O14949,O43676,O75251,P51970,Q9Y6M9,O96000,P49821,Q9BQ95,O95182,P20674,Q16795,P00403,Q9H845,O43819,O75489,P13804,O75880,O95299,Q9P032,O95168,Q86Y39,P13073,P31040,P22695,P19404,P10606,P42704,P31930,O75306,P28331,Q16134,O00483 Transmission across chemical synapses -0.23705485073751661 -1.180730594204338 0.23770976366844954 1.0 0.4511943284917068 78 O14795,Q9NRD5,Q96RR4,Q9NUP9,P20336,Q16566,P16220,P24588,P01111,P62879,Q9HAV0,P68366,Q9Y2X7,Q9Y478,P31323,Q9BQE3,Q01970,P15104,P22694,P31321,O60266 Biosynthesis of specialized proresolving mediators spms 0.5014567662967965 1.1793182853166055 0.2382714597895672 1.0 0.45165196749403624 3 P09960 Diseases of mitotic cell cycle 0.2931779397098476 1.1786009503775916 0.23855711303208493 1.0 0.45165196749403624 19 Q16763,Q9UJX4,Q96DE5,Q13309,Q9H1A4,Q9UJX2,P11802,Q9UJX3,P30260,P24941 Antimicrobial peptides -0.46692915067862506 -1.1629042825309426 0.2448683397030953 1.0 0.4621395712074066 7 P35030,Q5EBL8,Q04656,P10909,O00244 Hur elavl1 binds and stabilizes mrna 0.43307714132998054 1.1622654993065953 0.24512763615104438 1.0 0.4621395712074066 7 O14980,P35658,Q15717 Telomere c strand synthesis initiation 0.4482539106309569 1.162057331900563 0.2452121775770415 1.0 0.4621395712074066 6 P49642,P49643,P09884 Creb1 phosphorylation through the activation of camkii camkk camkiv cascasde -0.5320789604516116 -1.161303746289524 0.24551839655112673 1.0 0.4621395712074066 5 Q96RR4,Q16566,P16220 Neuronal system -0.22915140549608845 -1.1605494590016092 0.24582516912800179 1.0 0.4621395712074066 95 O14795,Q9NRD5,Q96RR4,Q13332,Q9NUP9,P20336,Q16566,Q86YM7,P16220,Q9Y2H0,P24588,P01111,P36383,Q9HAV0,P68366,P62879,Q9Y2X7,Q9Y478,P31323,Q9BQE3,Q01970,P22694,P31321,O60266 Downregulation of smad2 3 smad4 transcriptional activity 0.41757976702983124 1.1602242816336543 0.24595750333387478 1.0 0.4621395712074066 8 Q13547,Q13573,P09874,Q93008 Signaling by fgfr2 0.22623820868989164 1.157098089053431 0.24723228733282676 1.0 0.4633661737432854 32 P26599,P30153,P52272,Q01085,P62487,P30876,P24928,P52597,P62993,P31943,P09651 Signaling by fgfr 0.22623820868989164 1.157098089053431 0.24723228733282676 1.0 0.4633661737432854 32 P26599,P30153,P52272,Q01085,P62487,P30876,P24928,P52597,P62993,P31943,P09651 Erk mapk targets 0.37608068499073827 1.1555650165661806 0.24785912431649737 1.0 0.46395740606982544 11 P51452,P51812,P28482,Q14738,P30153,Q15418 Caspase mediated cleavage of cytoskeletal proteins 0.4012917481901146 1.152930600370054 0.24893887087092037 1.0 0.4653938740246817 9 P08670,Q13813,P35611,Q15149 Laminin interactions -0.46514337017790386 -1.1515240069827195 0.24951672462578278 1.0 0.46588962367470715 7 P23229,P14543,P06756,P17301 Endogenous sterols -0.5552931995736983 -1.1489347536649637 0.2505828857510781 1.0 0.4672947431403084 4 P10109,O75881 Repression of wnt target genes -0.4643622789292202 -1.1465451181054147 0.2515696699680672 1.0 0.468168233500511 7 Q08117,P01106,Q04727 Ecm proteoglycans -0.4378931981212454 -1.1462790672578076 0.2516797013650398 1.0 0.468168233500511 9 Q13332,P17301,P06756,P13591,Q14118 Diseases of immune system -0.45081310044302564 -1.1440291383490433 0.25261155303726146 1.0 0.4693157282113711 8 P19838,Q9Y6K9,Q9H1C4,Q00653,Q04206 Prolactin receptor signaling -0.47689817032719717 -1.1432437741680361 0.2529373922405638 1.0 0.4693358834849814 6 P62877,Q9Y297,P51692 Displacement of dna glycosylase by apex1 0.5207306242005109 1.1322056201804456 0.2575479978375368 1.0 0.4767099779847578 4 Akt phosphorylates targets in the cytosol -0.4489648964896388 -1.1318258093408504 0.25770767470552314 1.0 0.4767099779847578 8 Q96B36,P49840,P31749,P49841,O15111,Q9Y243,P49815,P31751 Biological oxidations 0.16744632958846603 1.131334612993527 0.25791428114057524 1.0 0.4767099779847578 66 P21964,P30837,Q9NZL9,P23526,Q8TB61,O43169,O00170,P21266,P78417,P11766,Q16851,Q9Y2Q3,P07099,Q99707,Q9NUJ1,O14880,P00387,P31153,P08238,O95861,O75223,P05091,P22570,Q96KP4,Q16850,P14550,Q5VT66,P48637,Q15185,P10768,O43488,O60701,O43252,P16435 Tristetraprolin ttp zfp36 binds and destabilizes mrna 0.3187717484565746 1.1302742345490548 0.2583606878693967 1.0 0.4767099779847578 16 Q5RKV6,Q9Y2L1,Q9NQT4,Q9NQT5,P31946,Q15024,Q92973 2 ltr circle formation 0.42740004052173447 1.129917040884888 0.2585111826924056 1.0 0.4767099779847578 7 O75531,O75475,P13010,P12956 Sulfide oxidation to sulfate -0.5508869171291769 -1.1258173045762345 0.2602428579811269 1.0 0.4793100845387875 4 Q9Y6N5,O95571 Rho gtpases activate paks 0.32864774703491906 1.1235790201975873 0.26119166049088305 1.0 0.4801000544535064 15 P60953,Q14247,P21333,P60660,P35580,P63000,P35579,Q13177 Apex1 independent resolution of ap sites via the single nucleotide replacement pathway 0.49062730440994334 1.1232856317002295 0.261316204135432 1.0 0.4801000544535064 3 P49916 Camk iv mediated phosphorylation of creb -0.47334648365330484 -1.12135276689813 0.2621377329644148 1.0 0.4810162833952932 6 Q96RR4,Q16566,P16220 Pentose phosphate pathway 0.36977772386986685 1.1161633191680305 0.26435223249277007 1.0 0.48427430210557854 11 P29401,P52209,O95336,P37837,P11413 Formation of the beta catenin tcf transactivating complex -0.32259478879489883 -1.1156703271520765 0.26456327645230937 1.0 0.48427430210557854 20 O00255,Q8N257,Q92793,Q09472,Q92993,P01106,Q8WVC0,Q04727 Synthesis of bile acids and bile salts via 7alpha hydroxycholesterol -0.47158971474537753 -1.1105214887783776 0.26677437349528255 1.0 0.48772247424290915 6 O95342,O75881 Attenuation phase 0.31568357641412603 1.1089921386598551 0.26743357333941065 1.0 0.4883284611222081 16 P11142,Q92598,P08238,P0DMV9,Q02790,P07900,P25685,P50454 Amino acid transport across the plasma membrane -0.41905484717134095 -1.107308916018308 0.26816039079450005 1.0 0.48866616966568227 10 Q01650,P52569,Q8N8R3 Synthesis of diphthamide eef2 -0.47102592344041405 -1.1070450589359087 0.268274447507737 1.0 0.48866616966568227 6 Q9BTV6,Q7L8W6 Nicotinate metabolism -0.444324782882236 -1.1011691711304152 0.2708230364911617 1.0 0.4926294397494731 8 Q8IXQ6,Q9UKK3,Q6IA69 Disassembly of the destruction complex and recruitment of axin to the membrane 0.37776169562634665 1.1005064893396352 0.2711115037547436 1.0 0.4926294397494731 10 P35222,Q14738,P48729,P30153 Scavenging by class b receptors -0.4760863547509167 -1.0969474345025685 0.2726643713803796 1.0 0.49484764111664503 2 P04114 Dna double strand break repair 0.12847273207178497 1.0917504098742647 0.2749428213250651 1.0 0.4983756736914197 92 Q5UIP0,Q9UIG0,P35249,P09874,P49959,P78527,P28340,P62805,P39748,P12004,O60264,P12956,P40937,Q9Y2S7,P04637,P53041,P49916,Q14676,P27694 Metabolism of folate and pterines 0.3654744666890831 1.0894458107285925 0.27595733902295105 1.0 0.4996068470767887 11 P13995,P34897,Q6UB35,Q9H2D1,P00374,P11586 Traf3 dependent irf activation pathway -0.45527804649854653 -1.0885949004392053 0.2763325665912344 1.0 0.49967903424871263 7 Q9UHD2,Q92793,Q09472,Q9BRV8,Q9C037 Constitutive signaling by akt1 e17k in cancer -0.39797466876145887 -1.0868501509490698 0.277103039728253 1.0 0.5004648838728448 12 Q9Y243,O43524,P16220,Q6R327 Phenylalanine metabolism 0.4825539568345577 1.0817291099524053 0.2793729143017949 1.0 0.503665904641669 3 P09417,P61457 Resolution of sister chromatid cohesion 0.10544066675281501 1.0809887976419312 0.27970209676488444 1.0 0.503665904641669 99 P30154,P53350,Q9Y266,Q14008,P46060,Q12769,Q14738,P06493,P63167,Q9UQE7,Q9BVA1,Q15005,P49792,Q8WUM0,Q9BUF5,P43034,Q8N3U4,Q2NKX8,Q9NTI5,P57740,Q99661,Q9Y6G9,Q7Z5K2,Q9P258,P14635,Q9BW27,P52948,O60566,O00139,Q29RF7,O14980,O43264,Q15691,Q96EE3,O60216,Q8NFH4,P30153,Q14683,Q14204,O43684 Conversion from apc c cdc20 to apc c cdh1 in late anaphase 0.35359094169431227 1.0805675819547742 0.2798895094250349 1.0 0.503665904641669 12 Q16763,P30260,Q9UJX4,Q9H1A4,Q9UJX3,Q9UJX2 Interleukin 15 signaling -0.5167039280059363 -1.0763990279091413 0.2817488369376413 1.0 0.5064002014922624 5 P23458,P29353,P51692 Plasma lipoprotein remodeling -0.5410597264726271 -1.0742442767174636 0.2827132125799978 1.0 0.506668032559355 4 P02656,P04114 Sema3a plexin repulsion signaling by inhibiting integrin adhesion -0.4529744170629564 -1.0738894877231924 0.28287221541700047 1.0 0.506668032559355 7 P51805,P06241 Interaction between l1 and ankyrins 0.5085438564722112 1.0737873772453725 0.2829179886505928 1.0 0.506668032559355 4 Q01082,Q13813 Phenylalanine and tyrosine metabolism 0.4827275998560826 1.0724558044753953 0.28351535450106535 1.0 0.5066982270817822 5 P09417,P16930,P61457,O43708 Activated notch1 transmits signal to the nucleus -0.45271509649204483 -1.0722339150358626 0.2836149807961117 1.0 0.5066982270817822 7 P32121,P78536,Q86YT6,P49768,P49407 Immunoregulatory interactions between a lymphoid and a non lymphoid cell -0.39569269096075826 -1.0696543997103507 0.2847748990327066 1.0 0.5079290280861454 12 P13747,Q9BZM4,P15151,P30511,P60033 Wnt5a dependent internalization of fzd4 0.3516869120726406 1.068605344721294 0.2852475391935063 1.0 0.5079290280861454 12 Q00610,P63010,O95782,O94973,P53680,Q96CW1 Muscle contraction 0.1959991722692936 1.0684300348113656 0.28532657483765345 1.0 0.5079290280861454 40 P54709,Q12797,Q9NYL9,P04083,P05023,P06753,P60660,P07355,Q9Y490,P18206,P30626,P08670,Q13177,P08133,P16615 Crmps in sema3a signaling -0.40413267758868093 -1.0649111771216921 0.2869161265659448 1.0 0.5101491987867037 11 P51805,Q9UIW2,P06241,Q14194,O14531 Formation of atp by chemiosmotic coupling 0.3299415865125126 1.0626469218459096 0.287942099791767 1.0 0.5113632046361536 14 P06576,O75964,P25705,P56134,P36542,P48047,O75947,P24539 Sumoylation of transcription cofactors -0.28935043892734325 -1.0555174143287138 0.29118874930555494 1.0 0.5156898042357488 25 Q8N2W9,Q92793,Q09472,O00257,Q9H160,P35226,P52739,Q06587 Processive synthesis on the c strand of the telomere 0.30776402006476433 1.05502708770749 0.2914129363289968 1.0 0.5156898042357488 16 P27694,P39748,Q9Y2S7,P12004 Ldl remodeling -0.4689704737780834 -1.0550189577713054 0.29141665447416143 1.0 0.5156898042357488 2 P04114 Notch hlh transcription pathway -0.4026670825236848 -1.0541768505408518 0.29180195654998187 1.0 0.5157590928344875 11 Q92793,Q92830,Q9UBN7,O15379 Bicarbonate transporters -0.4686207516633814 -1.052959343184835 0.2923596261562895 1.0 0.5161325153707007 2 Q9Y6M7,P04920 Rrna processing in the mitochondrion -0.41090913031334964 -1.0493491715262602 0.2940174426810698 1.0 0.5184449581003479 10 Q6IN84,Q7Z6M4,Q9UI43 Sensory processing of sound 0.2375229648377389 1.038027195481713 0.29925739412468877 1.0 0.5264463556116881 24 Q00013,P20020,P26038,Q01082,P15311,O00159,P35241,P47755,P47756,O14936,Q12792,P35579,P56545,P52907,Q13813 Clathrin mediated endocytosis 0.11490472965981378 1.037288144430635 0.29960158932147096 1.0 0.5264463556116881 90 P11142,Q9NVZ3,P53680,P61160,Q7L5N1,P51148,Q00610,Q14C86,O95782,Q99961,O15145,Q96CW1,Q14108,P50570,Q9Y5X1,Q9UNS2,P61020,P61201,Q9UNF0,O14976,P62993,Q92747,P59998,Q13492,Q9BT78,P51809,P02786,Q13098,P63010,Q14247,O94973,P11717,P20339,O15144,Q92905,Q8N6T3,Q99627,P61158 Ddx58 ifih1 mediated induction of interferon alpha beta -0.27008020394178694 -1.0372591308391488 0.2996151070863835 1.0 0.5264463556116881 32 Q9UHD2,P19838,Q92793,Q9UII4,Q09472,Q9BRV8,Q9Y6K9,Q86VP1,Q96G74,Q9H1Y0,Q13158,Q00653,Q04206,Q9C037,Q14790 Oncogenic mapk signaling 0.1868901042411515 1.0342543653676073 0.30101726465812595 1.0 0.5282870722504213 43 Q96PU8,Q53H12,P18206,Q7KZF4,Q99956,P51114,P31946,P62140,P28482,Q7Z2W4,Q9Y490,P02545,P46940,P30086,O00203,Q9NRY5,Q6WCQ1,Q13555,P35232,P41240,O43252 Ion homeostasis 0.314871896663778 1.0318054466835043 0.3021632672093255 1.0 0.5295242439325151 15 P20020,P54709,Q12797,P17612,Q13555,P05023,P30626,O43865,P16615 Nod1 2 signaling pathway -0.3723193368174518 -1.0305462400303316 0.30275365760335404 1.0 0.5295242439325151 14 Q13685,O43318,Q13404,Q96J02,Q9Y6K9,O15111,Q15750,P52564,Q16539,Q14790,O14920,P42575,P51617,P61088 Dna damage recognition in gg ner 0.22706416755338682 1.0304722771199328 0.30278835961778716 1.0 0.5295242439325151 27 Q13098,P61201,Q13620,Q16531,Q9BT78,Q9Y265,Q92905,Q99627,Q7L5N1,P54727,P09874 Role of lat2 ntal lab on calcium mobilization -0.5075729449342451 -1.0259616097358568 0.3049096801255482 1.0 0.5321440498977624 5 P06241,P29353 Processing of capped intronless pre mrna 0.23279887633225171 1.0257426019149707 0.3050129277079874 1.0 0.5321440498977624 25 O43809,P62304,Q6UN15,Q12996,Q10570,Q8N684,P33240,Q05048,Q92797,P51003,Q9UKF6,Q86U42,P62318,Q09161 Signaling by braf and raf1 fusions 0.19987261058058625 1.0250113605153435 0.3053578272903268 1.0 0.5321440498977624 35 Q13555,P41240,Q96PU8,P28482,O43252,Q7Z2W4,Q53H12,Q9Y490,O00203,P18206,P02545,P30086,Q7KZF4,P46940,P51114,Q6WCQ1,P31946,Q9NRY5 Epigenetic regulation of gene expression 0.14873768119147315 1.022977130070708 0.30631865913583867 1.0 0.5331948622808407 68 Q9NY93,Q13185,P26358,O75533,Q92769,P17480,Q9UIG0,Q9GZS1,O00422,P35659,Q9BQG0,Q8WXI9,P62805,Q13547,O15160,Q14839,Q15022,O43159,Q86YP4,O60264,P16104,P18074,O94776,O95983,Q96T88,Q15393,O00159,Q96ST3,P19447,Q13330,O95602,Q9H9Y6,P19388,Q9NR30 Factors involved in megakaryocyte development and platelet production 0.1462782089188759 1.0167640772958277 0.30926567490037793 1.0 0.5370041172404154 69 P13861,P17612,O60341,P33176,P10644,Q14807,P45973,P63000,Q9BVA1,Q9H0H5,Q13885,P60953,Q07866,Q9BUF5,P68371,Q13547,Q99661,P52907,P24941,Q96N67,Q9BW19,Q00535,O95235,Q8IWA4,O95239,P52732,Q9H4M9,O00139,P47755,P47756,O95140,P04637,Q96ST3,P20339,Q92667,Q92769,Q02241 Regulation of gene expression in beta cells -0.5057701495167418 -1.016006064675005 0.30962649856579594 1.0 0.5370041172404154 5 Q9Y243,P31749,P26367 Synthesis of pe -0.45621851289007814 -1.015707798965026 0.3097685530574399 1.0 0.5370041172404154 6 Q9HBU6,Q99447,Q9Y6K0,Q9C0D9 Rhof gtpase cycle -0.2656079542559059 -1.0153297133065597 0.30994868511862905 1.0 0.5370041172404154 33 Q658P3,Q8WUY9,Q9UHR4,Q5T5U3,Q13613,Q6ZW31,O75044,Q15836,Q8IWW6 Defects in cobalamin b12 metabolism -0.405920823726687 -1.0138162087198406 0.3106704595459493 1.0 0.5376294828379378 10 Q9H3L0,Q9Y4U1,Q8IVH4,O14678,Q9NUN5,Q9UBK8,Q9NPF0 Tetrahydrobiopterin bh4 synthesis recycling salvage and regulation 0.4953981599935005 1.011349344833136 0.3118492564862576 1.0 0.5390433783811182 4 P07900,P00374 Suppression of phagosomal maturation 0.3914913040712936 1.0095723014231266 0.3127002456281498 1.0 0.5392157820370715 8 P52294,P20339,P51149,Q9UI12,Q14974 Pi3k akt activation -0.46106815320986555 -1.0085133155995314 0.3132080985655783 1.0 0.5392157820370715 2 P61586,O00459 Serine biosynthesis -0.5044003736936526 -1.0084428034885509 0.31324193300261616 1.0 0.5392157820370715 5 Q9GZT4,Q9NRX5 Mitotic spindle checkpoint 0.09502449867703837 1.0081206293988076 0.3133965551973852 1.0 0.5392157820370715 90 P30154,P53350,Q9Y266,Q14008,P46060,Q12769,Q14738,P63167,Q15005,P49792,Q8WUM0,P43034,Q2NKX8,P57740,Q99661,Q9Y6G9,P30260,Q16763,Q9P258,Q9UJX4,Q9BW27,Q13409,P52948,Q9UJX3,O60566,O00139,Q7Z460,O14980,Q9H1A4,O43264,Q15691,Q96EE3,Q8NFH3,Q8NFH4,P30153,Q9UJX2,Q14204,O43684 Tfap2 ap 2 family regulates transcription of growth factors and their receptors -0.49400910038796886 -1.0046763946811383 0.3150526982026305 1.0 0.5411846587416206 3 P00533,P25490 Uptake and function of anthrax toxins -0.4420657164162211 -1.0042309556518374 0.3152673045555212 1.0 0.5411846587416206 7 O14733,P45985,P52564,P46734 Molecules associated with elastic fibres 0.46603604278881744 0.9974438123933954 0.31854913405526597 1.0 0.5455611606233866 3 Elastic fibre formation 0.46603604278881744 0.9974438123933954 0.31854913405526597 1.0 0.5455611606233866 3 Tight junction interactions -0.5019599878001397 -0.994970779613376 0.31975047621802055 1.0 0.5469899076519524 5 Q8TEW0,Q8NI35,P41743,Q8N3R9 Signaling by insulin receptor 0.23751160894707044 0.9908826728113453 0.32174287408975966 1.0 0.5494257759815945 22 P61421,P21283,Q9Y5K8,P28482,P36543,Q15904,Q99570,Q9UI12,P62993,Q93050,Q06124,P27361,Q9Y487,P21281,P38606 Homologous dna pairing and strand exchange -0.2662098445762651 -0.9905366575952056 0.3219118808268 1.0 0.5494257759815945 32 Q06609,Q9H9A7,O43502,Q8WXE1,Q96B01,O43542,O60671,Q13535,Q9BX63,Q13315,Q99728,Q99638,Q92993,Q13472,Q14191 Global genome nucleotide excision repair gg ner 0.15031972492129853 0.9891028937967744 0.32261280193846886 1.0 0.549992076531257 62 P40938,Q13620,O96019,P18858,Q07864,Q86WJ1,P35249,Q7L5N1,P09874,P15927,Q16531,P28340,Q9Y265,P35250,P12004,Q9UNS2,P61201,P18887,P40937,P18074,P61088,P54727,P41440,Q9Y2S7,Q9BT78,Q13098,P35251,P19447,P49916,Q92905,Q99627,P27694 Activation of puma and translocation to mitochondria 0.43736365382035697 0.9879249664930564 0.3231893971045503 1.0 0.5503453733551771 2 Regulation of tp53 activity through methylation -0.414238609486997 -0.9840954282994101 0.3250685945510603 1.0 0.5529134770331962 9 Q9NRG4,Q8N0Z6,Q09472 Traf6 mediated irf7 activation in tlr7 8 or 9 signaling -0.4897114915826428 -0.9808721106588171 0.3266558122459502 1.0 0.5549796582057763 3 P51617,Q13404 Molybdenum cofactor biosynthesis -0.45024293683643 -0.978858286411056 0.3276500054332345 1.0 0.5560347472614117 6 Q9NZB8,Q9Y697,O96007,Q9NQX3,O95396,Q96EN8 Wax and plasmalogen biosynthesis 0.46350269063521105 0.9773930132048096 0.3283746206243334 1.0 0.5566304718205424 5 Q8WVX9,O00116,Q6IAN0 Activation of anterior hox genes in hindbrain development during early embryogenesis -0.2597426446408756 -0.9758567389280858 0.329135462865614 1.0 0.5572861814429146 34 Q8N257,P84243,O15550,P26367,Q15910,Q92793,P05412,O75928,Q09472,Q6ZW49,O15379,P61218,P25490,Q9ULM6 Meiosis 0.1897000645663574 0.9738376414046453 0.33013716006206173 1.0 0.5583477508427604 36 Q8WXH0,Q92878,P20700,Q9UQE7,P49959,P15927,Q8N3U4,P62805,P02545,P24941,P16104,O60934,P54652,O94901,P11802,Q9BTC0,Q9UH99,O60216,P27694,Q14683 Runx1 regulates transcription of genes involved in differentiation of myeloid cells -0.5211368951250233 -0.969757530217454 0.3321673666893097 1.0 0.5611444176497409 4 Q13951,P17931,Q92793,P05771 Interleukin 20 family signaling -0.4485479369017118 -0.9684100814544798 0.33283960654817735 1.0 0.5616432771877511 6 P23458,P29597,P51692 The canonical retinoid cycle in rods twilight vision -0.48712730304707774 -0.9665695335056673 0.33375927109365944 1.0 0.5619551357148023 3 P09455,P29374 G2 m dna replication checkpoint 0.48570655262567797 0.9657835625053853 0.3341524953127122 1.0 0.5619551357148023 4 P06493 Traf6 mediated irf7 activation -0.42379878053572395 -0.9653846519406817 0.33435218599005045 1.0 0.5619551357148023 8 Q9UHD2,Q92793,Q09472,Q9BRV8,Q9C037 Phospholipid metabolism -0.2205075081423833 -0.9650235352791837 0.33453302374431515 1.0 0.5619551357148023 89 Q8TCG2,O15357,O95248,P68400,P78356,O95379,O15120,Q8NEB9,Q99447,Q9Y2I7,Q12923,P49585,Q9NRZ5,Q08AM6,O43426,Q13496,Q96AD5,Q643R3,Q32NB8,Q9HAU0,Q8IWA5,Q9NZC3,Q9HBU6,O94830,Q9BT40,Q9Y6K0,Q13613,P48426,Q9NYA4,Q9C0D9,Q9C0I1,Q8WWI5,Q7L5N7 Polb dependent long patch base excision repair 0.383277528591879 0.9631745567803446 0.3354599312243691 1.0 0.5628775873021509 8 P27695,P09874 Purine catabolism 0.3545664990350869 0.9615879314914433 0.3362566361587356 1.0 0.5635797388937187 10 P36639,Q9BY32,Q9UKK9,P00491,O43598 Ret signaling -0.38122423609757167 -0.9604374145153536 0.33683511538079824 1.0 0.5637411089254397 12 Q13164,Q13322,P29353,P22694 B wich complex positively regulates rrna expression 0.21770276493967672 0.9595694489683433 0.33727195117692155 1.0 0.5637411089254397 27 O00159,P35659,O60264,Q9NY93,Q9BQG0,O75533,P62805,Q9UIG0,O95602,Q9H9Y6,Q9NR30 Cargo trafficking to the periciliary membrane 0.21443821617894362 0.9591405082100609 0.33748796588019614 1.0 0.5637411089254397 28 P17987,Q9UPT5,Q10713,P78371,O00471,P48643,P50991,Q92538,P61006,P18085,P50990,P36405,P49368 Transcriptional regulation of pluripotent stem cells -0.5170928567626317 -0.948583192555514 0.342832642602966 1.0 0.5720275895614998 4 Q92908,Q99626,Q13485 Phase ii conjugation of compounds 0.17646391806563985 0.9475659421013385 0.3433504713501685 1.0 0.5722507855836142 42 P21964,Q9NZL9,P23526,Q8TB61,P21266,P78417,Q16851,Q9Y2Q3,Q99707,Q9NUJ1,O14880,P31153,O95861,O75223,Q96KP4,P14550,P48637,P10768,O43252 Dcc mediated attractive signaling -0.40819303348309327 -0.942601371827534 0.34588483789211355 1.0 0.5747448803005731 9 P12931,Q05397,P06241,O00401,O75962,P16333 Trans golgi network vesicle budding 0.14905364633465548 0.9422012181652822 0.3460896303724066 1.0 0.5747448803005731 56 P11142,Q01968,P55327,Q8NBS9,P51148,Q00610,Q14677,Q10567,Q14789,P50570,Q9Y5X1,O43747,O60749,P09496,O14976,O00203,P54920,Q13492,P51809,P02786,O75976,Q9BXS5,P11717,O00161,O00443,Q9Y5X3,Q92538,P15586,Q9H3P7 Detoxification of reactive oxygen species 0.311023433473494 0.942165730861935 0.3461077959557335 1.0 0.5747448803005731 14 P32119,P07237,Q96HE7,P30041,P00390,P30048,P30044 Sensory processing of sound by outer hair cells of the cochlea 0.2803595671451168 0.9416148433710521 0.3463898674563186 1.0 0.5747448803005731 17 Q01082,Q00013,P26038,O00159,P15311,P35241,Q14651,O14936,Q12792,P35579,Q13813 Translation of replicase and assembly of the replication transcription complex -0.3956419953178665 -0.9405555655345996 0.34693266186636906 1.0 0.5750051904125583 10 Q8NEB9,Q9H444,Q9UQN3,Q96FZ7,Q9BY43,O43633,Q99570,Q8WUX9,Q14457,Q9Y3E7 Inla mediated entry of listeria monocytogenes into host cells 0.45406538418442605 0.9371411068065657 0.34868597895443343 1.0 0.5772690096023397 3 P35222 Propionyl coa catabolism -0.49088818444970694 -0.9339120817416127 0.3503492461249187 1.0 0.5789903376276646 5 Q96PE7,Q8IVH4 Mitochondrial fatty acid beta oxidation of unsaturated fatty acids 0.4545159297546809 0.9336143206512486 0.35050287553030435 1.0 0.5789903376276646 5 P40939,P11310,P55084 Caspase activation via extrinsic apoptotic signalling pathway -0.40617327928146335 -0.9287420850879708 0.35302276483237893 1.0 0.5825071091918546 9 Q13158,O43293 G2 m dna damage checkpoint 0.15028206027098387 0.9267817694556462 0.35403985220489465 1.0 0.5829629419324693 54 P40938,Q92878,P06493,Q9UQ84,P62258,P35249,P31946,P49959,Q04917,P62805,P27348,P35250,P63104,P61981,P14635,P40937,O60934,P04637,Q14676,P27694,O96028 Regulation of tp53 activity through association with co factors -0.4417768403127703 -0.9267015386894136 0.35408151842207025 1.0 0.5829629419324693 6 Q9Y243,Q8N9N5,P31749,Q13625 Hiv transcription elongation 0.1898228794685881 0.9251339206251962 0.35489625056598273 1.0 0.5836593966261746 34 O00267,P35269,Q08945,P30876,P24928,P19387,P23193,Q09161,P62487,Q9Y5B9,O15514,Q8WX92,Q15370,Q8IXH7,P18074,Q14241,P62875,P19447,P18615,Q9H3P2,P19388 Egfr interacts with phospholipase c gamma -0.44611308982274417 -0.9207858868749363 0.3571622247508712 1.0 0.5867383846513761 2 P00533 Bbsome mediated cargo targeting to cilium 0.33730801006437894 0.9192760877390149 0.3579511819105301 1.0 0.5873868513730064 11 P17987,P48643,P50991,P50990,P49368 Lrr flii interacting protein 1 lrrfip1 activates type i ifn production -0.5112224600724843 -0.9178812380423949 0.3586810451685569 1.0 0.5879370267339382 4 Q92793,Q09472,Q32MZ4 Smooth muscle contraction 0.27633997385391934 0.9154379237305544 0.35996177699780385 1.0 0.5893879645348656 17 P08133,P04083,P60660,P07355,Q9Y490,P06753 Maturation of protein 3a -0.44480668348993213 -0.9131467304793115 0.3611653758763629 1.0 0.5907095609832939 2 Q11206 Chromatin modifying enzymes -0.20565356764013873 -0.9085935446578342 0.3635647153135688 1.0 0.5939818265539666 132 P19838,Q9P2N6,Q9ULD4,O75529,Q9NRG4,Q68DK7,P29374,Q0PNE2,Q8NFD5,Q9Y4C1,Q9HAF1,O75486,Q9H5I1,Q4LE39,Q9BTC8,P55201,Q01658,Q8NEM7,O15550,Q8IYH5,Q92794,Q12962,Q92993,Q00653,Q96EZ8,Q9NS73,Q8N257,P41229,Q8WYH8,Q92793,Q09472,Q9UMN6,Q8TEK3,Q92830,Q9H7L9,Q8NHM5,O15379,Q9UGL1 Translocation of slc2a4 glut4 to the plasma membrane 0.14906984069024626 0.9054078837664841 0.3652493406608919 1.0 0.5949909221673872 53 P51153,O00471,P61106,P63000,P35579,P62258,P61006,Q9BVA1,Q13885,P31946,Q9BUF5,P68371,Q04917,P11233,O60343,Q9UIQ6,Q8TAG9,P27348,P54619,P31751,P63104,P61981,Q96KP1,O00186,P04350,P61026,Q9UPT5,O00159,O00161 Ephrin signaling -0.38235951939185076 -0.9052454937099521 0.3653353453344166 1.0 0.5949909221673872 11 P12931,Q9Y2X7,O43639,P06241,Q13153,P98172 Acetylcholine regulates insulin secretion -0.48566543015274344 -0.9051605626082555 0.36538033139809345 1.0 0.5949909221673872 5 Q01970,P17252,P50148,P29992 Miscellaneous transport and binding events -0.3737944873108018 -0.9042903015280821 0.3658414880742171 1.0 0.5950915035268378 12 Q8N8Q9,Q6P9F7,Q9HD23,Q6NSJ5 Activated ntrk2 signals through fyn -0.47461642508065205 -0.8974829898726746 0.3694612461269633 1.0 0.6000271351267503 3 P12931,P06241 Ptk6 regulates rho gtpases ras gtpase and map kinases -0.4015558778263177 -0.8970707834584305 0.3696811476821187 1.0 0.6000271351267503 9 Q9NRY4,P20936,P01111,P49023 Irf3 mediated activation of type 1 ifn 0.42009232207733305 0.8944232827143082 0.3710954598260696 1.0 0.6016672852457494 2 Runx1 regulates genes involved in megakaryocyte differentiation and platelet function -0.2897312782224589 -0.8860197298914095 0.37560689554085935 1.0 0.6083198634303049 21 Q8N257,Q9UPQ9,Q09472,Q8NDV7,Q9UL18,Q9UMN6 Trna modification in the nucleus and cytosol -0.26473024889276975 -0.8847335534963522 0.37630035431693676 1.0 0.6087812463976502 29 Q9H3H1,Q9NWX6,Q9NXH9,Q96BT7,Q96S44,O60294,Q96EY9,Q8TEA1,Q32P41,Q9BXR0,Q9Y3C4 Cd28 dependent pi3k akt signaling -0.4221969553854758 -0.8775103519479086 0.3802094985968578 1.0 0.6144383437194341 7 O00459,P06241,P31749,Q6R327,Q9Y243 Transcriptional regulation of granulopoiesis -0.3528664818262399 -0.8743097593186128 0.3819495859667237 1.0 0.6165816718206049 14 Q8N257,Q09472,P29590,P16220,P01106 Constitutive signaling by overexpressed erbb2 0.3948696616621651 0.8722286156530261 0.38308367152359724 1.0 0.6177431499677055 6 P07900,P62993 Reproduction 0.17240727330733208 0.8665719717071967 0.38617657615782064 1.0 0.6219918309855033 37 Q8WXH0,Q92878,P20700,Q9UQE7,P49959,P15927,Q8N3U4,P62805,P02545,P24941,P16104,O60934,P54652,O94901,P11802,Q9BTC0,Q9UH99,O60216,P27694,Q14683 Cell junction organization 0.204447440250971 0.8658848492425506 0.3865533124111249 1.0 0.6219918309855033 27 Q14315,Q15149,P21333,P35222,P12814,P55196,P14923,O60716,P05556,P35221 Phase i functionalization of compounds 0.21971071680026705 0.863050227646611 0.3881098517004111 1.0 0.62316458584395 22 Q16850,P00387,O43169,P08238,P30837,P05091,P11766,P16435,P07099 Glutamate neurotransmitter release cycle -0.4314187867662569 -0.8630342892318085 0.3881186145390507 1.0 0.62316458584395 6 O14795,P20336 Creb phosphorylation -0.47770075216112773 -0.8614038399653355 0.3890156618827263 1.0 0.6239325470454922 5 P16220,P18846,P49137 Runx3 regulates cdkn1a transcription 0.4136350852259539 0.8599660415543573 0.38980776191148325 1.0 0.6245307153205485 2 Formation of rna pol ii elongation complex 0.15590637406120125 0.8579176683437879 0.39093792728325716 1.0 0.6256686483910345 45 O00267,Q6PD62,Q08945,P30876,P24928,P19387,P23193,Q09161,Q9GZS3,P62487,Q9Y5B9,Q15370,Q8IXH7,P18074,Q8N7H5,Q14241,P62875,Q6P1J9,P19447,P18615,Q7KZ85,P19388 Nicotinamide salvaging -0.4765859374130028 -0.8552894320184421 0.39239093656441115 1.0 0.6273202741212153 5 Q8IXQ6,Q9UKK3 Metabolism of nitric oxide nos3 activation and regulation 0.3493963457003389 0.8527782683942094 0.3937822773951609 1.0 0.6288698749397533 9 P07900,Q9Y314,P50570,O75608 Thromboxane signalling through tp receptor -0.3945381529220832 -0.8489888369095954 0.3958875039238332 1.0 0.6294622917332404 9 Q9HAV0,P50148,P62879 Ldl clearance 0.275730832720221 0.8484425472744428 0.3961915559371736 1.0 0.6294622917332404 16 Q00610,P63010,O95782,O94973,P53680,Q96CW1,P09496,P61916,P38571,O15118 Signaling by fgfr2 iiia tm 0.305399966379847 0.8484346648499309 0.3961959441416878 1.0 0.6294622917332404 13 P62487,P30876,P24928,P19387,O15514,P19388,Q09161,P62875 Fgfr2 mutant receptor activation 0.305399966379847 0.8484346648499309 0.3961959441416878 1.0 0.6294622917332404 13 P62487,P30876,P24928,P19387,O15514,P19388,Q09161,P62875 Endosomal vacuolar pathway -0.4176054374879187 -0.8483096886380862 0.396265523252201 1.0 0.6294622917332404 7 P30511,P13747,P07711 Pink1 prkn mediated mitophagy 0.3149735768061149 0.8470229094976576 0.3969823521210418 1.0 0.6299293979343475 12 O96008,Q15388,O94826,P21796,Q8N4H5,Q9NS69,Q8IWA4 Rho gtpases activate rocks 0.30500686765986296 0.8461441280822535 0.3974723460512444 1.0 0.6300359527833554 13 O75116,P62140,P61586,P23528,Q16512,Q7Z406,P60660,P35580,P35579,Q13464 Dna damage reversal 0.3888311756485604 0.8408299267630921 0.4004432190732454 1.0 0.634070559425224 6 Q6P6C2,Q8N3C0,Q9C0B1 Hyaluronan metabolism 0.3876695603623387 0.8348329670209101 0.4038117612599359 1.0 0.6380482760098676 6 P06865,P07686 Hyaluronan uptake and degradation 0.38766956036233857 0.8348329670209094 0.40381176125993634 1.0 0.6380482760098676 6 P06865,P07686 Processing and activation of sumo 0.4566956944401199 0.8324642900320977 0.40514692658720164 1.0 0.6394797887870025 4 Q9UBE0 Interleukin 23 signaling -0.4620336341882693 -0.8283622759402558 0.40746536396442634 1.0 0.6424586161978786 3 P29597 Bh3 only proteins associate with and inactivate anti apoptotic bcl 2 members -0.42942360877000885 -0.8236075432780291 0.4101625884731175 1.0 0.6459770678324108 2 Q13794 Activation of gene expression by srebf srebp 0.1978926527538902 0.8229016075418368 0.41056394848140476 1.0 0.6459770678324108 27 Q16850,P48449,Q9UBM7,Q13085,Q01581,P49327,P14324,P37268,Q13907 G1 s specific transcription 0.280817711189413 0.819038530861633 0.4127644305331153 1.0 0.6487542209855927 15 P04183,P09884,Q13547,P04818,P00374,P06493,P31350,P12004 Regulation of pten gene transcription -0.24016662785293125 -0.8172094717939689 0.41380873055392886 1.0 0.6497102302690769 39 Q9UHA4,O95503,O43504,Q9HB90,P05412,O00257,P35226,O15379,Q0VGL1 Fcgamma receptor fcgr dependent phagocytosis 0.12991331119551225 0.8160001151947874 0.41450006982826615 1.0 0.6501106358359122 52 Q8IV08,P61160,P63000,P35579,P60953,P23528,P28482,O15145,Q7L576,Q9Y2A7,P08238,P07900,P59998,P62993,O43865,O00159,O15144,Q9UQB8,P61158 Clec7a dectin 1 induces nfat activation -0.49084551842814933 -0.8117845930241099 0.41691524418776416 1.0 0.6532110555623224 4 Q14571,Q12968 Estrogen dependent nuclear events downstream of esr membrane signaling -0.37692376617937806 -0.8073125887614786 0.41948641300625167 1.0 0.656549112793398 10 Q05397,P31749,O43524,Q9Y243,P00533,P16220 Pi3k akt signaling in cancer -0.27272212110872596 -0.8058159524353572 0.42034897849346 1.0 0.6572087911387778 22 P06241,O43524,Q6R327,Q9Y243,P00533,P16220 Condensation of prophase chromosomes 0.278203232950648 0.8037758879301777 0.42152641753624476 1.0 0.6583588701561893 15 O95347,P53350,P14635,P62805,Q9NTJ3,Q01105,P06493 Other interleukin signaling -0.4100080477879225 -0.8001094177697469 0.42364740513421095 1.0 0.6609786739790307 7 P23458,P29597 Heparan sulfate heparin hs gag metabolism -0.3677154115514455 -0.7979546194244508 0.4248968253769889 1.0 0.6618906522971859 11 Q9Y251,O94923,P51688,O94766,Q9H1B5 Regulation of mecp2 expression and activity -0.2901483813412013 -0.7975694730722526 0.4251203719787966 1.0 0.6618906522971859 20 Q9UPQ9,O15379,Q16566,Q8NDV7,Q9UL18,P16220 Grb2 sos provides linkage to mapk signaling for integrins 0.4480554555729429 0.7938609069410419 0.4272764102840432 1.0 0.6629670999344762 4 Q9Y490 Signaling by erbb2 -0.27159005490454635 -0.7937910369621503 0.4273170914356974 1.0 0.6629670999344762 22 Q9Y316,P06241,P01111,Q9Y243,P00533,P29353 Glutathione synthesis and recycling 0.3658116772760961 0.7935487654459877 0.4274581692701189 1.0 0.6629670999344762 7 Q96KP4,Q8WUX2,P48637,O75223,P48507 Early phase of hiv life cycle 0.3149852510005226 0.7922819477230824 0.4281962952732936 1.0 0.6629670999344762 11 O75531,P52294,P12956,O75475,P13010,P39748 Hdms demethylate histones -0.33429145689197065 -0.791901132124788 0.42841832680472924 1.0 0.6629670999344762 15 Q9Y4C1,P41229,O15550,Q8NHM5,Q9UGL1 Negative regulation of met activity -0.35079999336373957 -0.7917929376366055 0.4284814209643628 1.0 0.6629670999344762 13 Q99963,P17706,O75886,Q96JA1 Erks are inactivated 0.35139875847978996 0.789860330303965 0.4296093409855073 1.0 0.6636349773485892 8 P51452,P28482,Q14738,P30153 Notch2 activation and transmission of signal to the nucleus -0.48640201983223136 -0.7887811973571596 0.43023990089228414 1.0 0.6636349773485892 4 Q86YT6,P49768 Retrograde transport at the trans golgi network -0.23927477900014824 -0.788765197862988 0.43024925377096457 1.0 0.6636349773485892 37 Q13439,Q96CN9,Q147X3,Q14746,P82094,Q9UP83,Q8N1B4,Q9NRW1,Q8N2H4,Q9Y2V7,Q9H9E3,O14662,Q9UIL1,Q96MW5,Q15836,Q7Z6M1,O94955,O43752,Q8WTW3 Regulated proteolysis of p75ntr -0.463911092939608 -0.7859941310749067 0.43187092546301176 1.0 0.6654474446120864 5 P19838,Q04206,P49768,P78536 Ikk complex recruitment mediated by rip1 -0.4074874010079082 -0.7841566094740995 0.43294822193112514 1.0 0.6664182341708434 7 Q13546,Q6SZW1,Q13404,Q9Y6K9,O15111,O14920,P61088 Shc related events triggered by igf1r -0.4852827823187416 -0.782996347007967 0.43362925720330403 1.0 0.6667777019947606 4 P08069,P01111,P29353 Mecp2 regulates transcription factors -0.422104480616878 -0.7813381519708632 0.4346036366101349 1.0 0.6671211873728207 2 P16220 Activation of the pre replicative complex 0.1808134746026958 0.7802633880610862 0.4352358582350242 1.0 0.6671211873728207 30 P33992,P25205,P09884,P33991,P15927,Q14566,P33993,Q9Y619,Q07864,P27694,P49642,P24941,Q9NR33,P49736,P49643 Signaling by alk -0.3652659132673974 -0.7800496120184568 0.4353616736033543 1.0 0.6671211873728207 11 Q09472,P01106,P29353,O15379 Mrna decay by 5 to 3 exoribonuclease 0.28365471256082786 0.7795707686973903 0.43564356732466747 1.0 0.6671211873728207 14 Q8IZH2,Q9Y333,Q86TB9,Q8IZD4,Q9Y4Y9,Q96F86,Q6P2E9,Q9Y4Z0,Q9NPI6,Q9UK45,P62310,P26196,P62312 Cell cell communication 0.13719998273861506 0.7770035248776667 0.43715669070363705 1.0 0.6682708954187597 45 Q14315,O43707,Q01082,Q15149,P21333,P35222,P12814,P55196,P14923,O60716,P62993,P46940,P05556,Q13813,P35221 Eph ephrin signaling 0.1279395963949484 0.776671848835607 0.43735239972383066 1.0 0.6682708954187597 48 P53680,P60660,P61160,P63000,P35579,Q92542,P60953,P23528,Q00610,O95782,O15145,Q96CW1,Q13177,P35580,P59998,Q92747,P63010,O94973,O15144,P61158 Signaling by bmp -0.4524426511864968 -0.7760154531394058 0.4377398616971204 1.0 0.6682708954187597 3 Q13485,Q12841 Signaling by vegf -0.22096984702785183 -0.7748228402578792 0.4384443509491369 1.0 0.6685697484050789 56 Q14571,P12931,Q16644,P49137,Q8WUW1,O43639,P06241,Q6R327,P01111,Q9NYB9,Q9Y243,Q92558,P20936,P49023,Q05513,P22694,P52735,P16333 Transport and synthesis of paps 0.42059421924003687 0.7734159307711831 0.43927626483020177 1.0 0.6685697484050789 3 Q8TB61 Irak1 recruits ikk complex -0.41672520688403414 -0.7731780806756049 0.4394169965162402 1.0 0.6685697484050789 6 P51617,Q13404,Q9Y6K9 Signaling by egfr -0.2676606214973735 -0.7726484905983245 0.43973043854830696 1.0 0.6685697484050789 23 P12931,Q99963,P01111,O75886,P00533,P49023,Q96JA1,P29353 Negative regulation of nmda receptor mediated neuronal transmission -0.3640129682996992 -0.7708976639066086 0.4407675919285605 1.0 0.6693707099185648 11 Q92796,Q13555,Q14168,P49593,Q13557,Q14012,Q16566,P35609,Q12959,Q15334,P07196 Gaba b receptor activation -0.38301050258391145 -0.7702430531063901 0.4411557296241817 1.0 0.6693707099185648 9 Q9HAV0,O60266,P62879 Trna processing in the mitochondrion 0.4194505732732578 0.7682855539050006 0.4423175551982199 1.0 0.6698684425357557 5 Q7L0Y3,Q9BQ52,Q99714 Cytosolic sulfonation of small molecules -0.38268464676250746 -0.7680229237362932 0.44247356596439036 1.0 0.6698684425357557 9 P50225,P0DMN0 Methylation 0.31041944222513895 0.7674189017092743 0.4428324938910868 1.0 0.6698684425357557 11 P21964,P31153,P78417,Q9NZL9,P23526 Cardiac conduction 0.2518443234738359 0.76540908890067 0.4440279824760065 1.0 0.6706095468568278 17 P20020,P54709,Q12797,P17612,Q13555,P05023,P30626,O43865,P16615 Erbb2 regulates cell motility -0.4818118745947228 -0.7650822552653282 0.44422256560247586 1.0 0.6706095468568278 4 P00533,Q9Y316 Complex i biogenesis 0.12774068338637734 0.7579928921337746 0.4484552378890623 1.0 0.6763140733347195 46 Q16718,O43676,O75251,P51970,Q9Y6M9,O96000,P49821,Q9BQ95,O95182,Q16795,Q9H845,O75489,O95299,Q9P032,O95168,Q86Y39,P19404,O75306,P28331 Vitamin b1 thiamin metabolism -0.41771171229729065 -0.7560968234148373 0.4495911463903459 1.0 0.6773415653403593 2 Q9BU02 Glycerophospholipid catabolism -0.4483812949640078 -0.7539580414797761 0.450874416805525 1.0 0.6785887687275073 3 Q8N9F7,Q8IY17,Q9NZC3 Other semaphorin interactions 0.3925933827754725 0.7500943959578231 0.45319785445356975 1.0 0.6813973795517849 2 Chaperone mediated autophagy 0.3069920716328011 0.7490375432348585 0.45383457744507627 1.0 0.6814551855408009 11 P11142,P07900,Q99497,P08670,O60664 Signaling by met -0.24634055568282023 -0.7485126360023788 0.4541510062026948 1.0 0.6814551855408009 32 Q99963,P01111,P17301,O75886,Q9NZ52,Q96JA1,P17706,P29353 Signaling by fgfr2 in disease 0.25715732605827135 0.7402920923855032 0.45912277808603497 1.0 0.6882222729861087 16 P62487,P30876,P19174,P24928,P62993,P19387,P19388,Q09161 Activation of ampk downstream of nmdars -0.34387526902773125 -0.7380178155489487 0.46050362311891213 1.0 0.6895983903991749 13 P68366,Q96RR4,Q9BQE3,Q9Y478 Signaling by ntrk3 trkc -0.3885303753507252 -0.7330789530414734 0.463510276152475 1.0 0.6934039271758913 8 P12931,P29353,Q13332,P01111 Erythropoietin activates phospholipase c gamma plcg -0.44372882877600806 -0.7287815758993053 0.46613528333666787 1.0 0.6958008074621528 3 P16885 Cytochrome p450 arranged by substrate type -0.45327041067408474 -0.7282154488545546 0.4664817103350407 1.0 0.6958008074621528 5 P10109,O75881 Rhoc gtpase cycle -0.22049779432989913 -0.7281636290401862 0.4665134272850273 1.0 0.6958008074621528 54 Q9NZN5,Q8WUY9,O94804,Q9NRY4,Q8N392,Q5T5U3,O15085,Q15836,Q9BST9,P08134,O15013,Q13459,Q12979,Q8N5G2,P52735 Defective ripk1 mediated regulated necrosis -0.4742229361929865 -0.7260614374878807 0.4678011079157911 1.0 0.6970236507945287 4 Q13158,Q12933,Q14790 Tp53 regulates transcription of dna repair genes 0.09956407632713202 0.7210288428633859 0.4708917690911467 1.0 0.6999989030665478 47 O00267,Q08945,P30876,P24928,P19387,P23193,P62487,Q9Y5B9,P43246,Q15370,Q8IXH7,P18074,Q9NVI1,Q14241,P62875,P04637,P19447,Q14676,Q9BXW9,P18615,P19388 Sars cov 1 infection -0.2549271346356329 -0.7208140541673295 0.47102392726801323 1.0 0.6999989030665478 27 Q8NEB9,P07711,Q11206,Q9BY43,Q9BYF1,Q8IXQ6,Q9UKK3,Q14457,P26572 Activation of bad and translocation to mitochondria 0.30156542317528745 0.720456636133212 0.4712438897631366 1.0 0.6999989030665478 11 Q04917,P62258,P31946,P27348 Sirt1 negatively regulates rrna expression -0.3972715478770457 -0.7197529584223672 0.4716771132072577 1.0 0.6999989030665478 7 Q8N257,Q15573 Nucleotide catabolism 0.2819643906442792 0.7179647725408104 0.4727790079381706 1.0 0.7007445111064341 13 P36639,Q9BY32,Q9UKK9,P49902,P00491,O43598 Coenzyme a biosynthesis -0.45122507250763955 -0.7171600250414694 0.47327536189704933 1.0 0.7007445111064341 5 P16260,Q9H999 Ticam1 rip1 mediated ikk complex recruitment -0.4074140723411953 -0.7166494600182656 0.47359041790884504 1.0 0.7007445111064341 6 Q13546,Q13404,Q9Y6K9,O15111,O14920,P61088 Diseases of carbohydrate metabolism 0.2717956911063563 0.7147494664196329 0.4747638656820725 1.0 0.7017838887562381 14 P37837,P15586,Q7Z4W1,P10253 Parasite infection 0.13522948190080614 0.7120940814508797 0.4764065190326765 1.0 0.7035140865794727 39 P60953,O00159,P28482,O15145,Q7L576,P61160,Q9Y2A7,O15144,P63000,P35579,Q9UQB8,P59998,P62993,P61158 Formation of apoptosome -0.38489845363893443 -0.709376289132763 0.4780909977447356 1.0 0.7051117828851345 8 Q9NQS1,Q96GX9,P98170,O14727,Q9BZF9 Trafficking of glur2 containing ampa receptors 0.3220212796809585 0.708130760814728 0.47886405870417215 1.0 0.7051117828851345 9 P63010,O94973,P53680,Q96CW1,P46459 Mitophagy 0.23189845391237404 0.7080597763823399 0.4789081371005075 1.0 0.7051117828851345 18 O96008,Q15388,O94826,P21796,Q8N4H5,Q9NS69,Q8IWA4,P67870,Q96HS1,P19784 Sema4d induced cell migration and growth cone collapse -0.36259997074226596 -0.705920876804223 0.48023734389873596 1.0 0.7063708217266699 10 P08134,Q9NZN5,O15085 Rhoa gtpase cycle -0.20790667754692302 -0.7017316185432684 0.4828465507249049 1.0 0.7090469885298493 81 O94804,Q5T5U3,Q6ZSZ5,Q13459,Q7Z628,P52735,Q96NT0,Q9NZN5,Q96P48,O15085,Q8IWB9,Q9BST9,Q8N5V2,Q12979,O15013,Q8N5G2,Q15836,B2RTY4,Q8WUY9,Q9NRY4,Q8N392,A1A4S6 Activation of noxa and translocation to mitochondria -0.40813776935092766 -0.7014719737348362 0.48300851903207853 1.0 0.7090469885298493 2 Q13794 Ras processing -0.37248136992655384 -0.6987227580111726 0.48472530858134766 1.0 0.7106325276257209 9 Q96GS6,Q7Z5G4,P01111 Signaling by retinoic acid -0.2973016158539676 -0.6982154428771299 0.485042470198227 1.0 0.7106325276257209 18 P29373,Q15119,O75911 G beta gamma signalling through cdc42 -0.382959768848706 -0.6967504388655986 0.4859589872154475 1.0 0.7108467622925582 8 Q9HAV0,Q13153,P62873,P62879 Vxpx cargo targeting to cilium 0.2873768856014256 0.6964567194392 0.486142852869877 1.0 0.7108467622925582 12 Q9UPT5,O00471,Q92538,P61006,P18085 Map3k8 tpl2 dependent mapk1 3 activation -0.3610259552595835 -0.6948305241612022 0.4871615165667902 1.0 0.7112535577964866 10 Q9UKB1,P19838,Q9Y297,Q9Y6K9,P45985 Butyrate response factor 1 brf1 binds and destabilizes mrna 0.24866234459800848 0.6944887395969874 0.4873757600739683 1.0 0.7112535577964866 16 Q13868,Q5RKV6,Q9Y2L1,Q9NQT4,Q9NQT5,P31946,Q15024 Glycogen synthesis 0.34578829360067603 0.6932683640634131 0.48814115259192037 1.0 0.7116735003541697 7 P36871,Q16851,Q96G03 E2f enabled inhibition of pre replication complex formation -0.36068450709085564 -0.6924263547148725 0.488669619937939 1.0 0.7117475402810647 10 O43929,Q9Y5N6,Q9UJA3,Q13415 Diseases of metabolism -0.20663422232737197 -0.6882382025568952 0.4913027902486764 1.0 0.7148839428423124 83 Q9BVK2,Q14376,O15305,P34059,Q9Y672,Q86SQ9,O75881,Q9H3L0,Q9H3H5,Q99519,P51688,Q8IVH4,Q9UKM7,Q9NP73,P10109,P51580,P49247,Q9UBK8,Q99758,O95340,Q9UHI8,Q9Y4U1,Q96E22,O43826,O94766,Q96F25,Q9NPF0,Q10469,Q9UPQ8,Q9H6U8,Q93063,P15291,Q14118,Q9NUN5,Q03154 Sensing of dna double strand breaks 0.3580233277262522 0.687348991600693 0.49186283299712596 1.0 0.7150006060153343 6 P49959,P52292,Q92878 Integration of energy metabolism -0.2309392306411836 -0.6865635587477172 0.4923577990314363 1.0 0.7150225346557895 38 P24588,P50148,P31323,P62879,Q9HAV0,Q01970,Q96A54,P22694,P31321,O60266 Ercc6 csb and ehmt2 g9a positively regulate rrna expression 0.21836551924343897 0.6856706609366434 0.4929208118671189 1.0 0.7151431447731326 19 Q86YP4,Q13185,P16104,P62805,O94776,Q13547,Q92769,Q14839,Q13330,O95983 Dna double strand break response 0.14942041746937934 0.6842838430215374 0.49379594744367195 1.0 0.715715916041898 33 P49959,O60264,P04637,P53041,P62805,Q9UIG0 Myogenesis 0.3301811392204094 0.682477103254444 0.49493731611000547 1.0 0.7162320036968598 8 P60953,P35222,P35221 Senescence associated secretory phenotype sasp 0.1573332667703323 0.6821985704089288 0.49511339852870173 1.0 0.7162320036968598 31 Q00534,P51812,Q16763,P30260,Q9UJX4,Q96DE5,P28482,Q9H1A4,P16104,P62805,P40763,P11802,Q9UJX3,Q9UJX2,Q15418,P24941 Signaling by fgfr in disease 0.1647435201302777 0.6800201354810741 0.49649171149342264 1.0 0.7174370138344417 29 O95684,Q16630,O94905,O95429,P62487,P35269,P30876,Q9UBW7,O15514,P19174,P40763,P24928,P42224,P62993,P19387,P19388,Q09161,P62875 Telomere extension by telomerase 0.2554612047689736 0.6793606206808896 0.496909394816875 1.0 0.7174370138344417 15 Q9Y230,O00743,O60832,Q5H9R7,Q9Y265,Q9NX24,P24941,Q9NY12 Chl1 interactions 0.42083642888761197 0.6765428699136983 0.49869603729957457 1.0 0.7184362644861467 4 P05556 Ticam1 traf6 dependent induction of tak1 complex 0.3772702751303573 0.672949676700934 0.5009793067130321 1.0 0.7184362644861467 2 Q15750 Irak2 mediated activation of tak1 complex 0.3772702751303573 0.672949676700934 0.5009793067130321 1.0 0.7184362644861467 2 Q15750 Alpha protein kinase 1 signaling pathway 0.3772702751303573 0.672949676700934 0.5009793067130321 1.0 0.7184362644861467 2 Q15750 Plasma lipoprotein assembly remodeling and clearance -0.25062734924187985 -0.6718464990914165 0.5016814230100706 1.0 0.7184362644861467 27 Q6UWW8,P02656,P04114,P02654,P22694,P98155 Nef mediated downregulation of mhc class i complex cell surface expression 0.34129053574894697 0.6716177596461691 0.5018270691792399 1.0 0.7184362644861467 7 Q10567,O43747,P04439 Reactions specific to the complex n glycan synthesis pathway -0.463508746602071 -0.6713723766100367 0.5019833377657474 1.0 0.7184362644861467 4 Q9BYC5,Q10469 Formation of the early elongation complex 0.17755749668369872 0.6710472084887401 0.5021904559765613 1.0 0.7184362644861467 25 Q8IXH7,O00267,P62487,P30876,O15514,P19447,P18074,P24928,P18615,Q9H3P2,P19387,P19388,Q8WX92,Q09161,P62875 Pkmts methylate histone lysines -0.24434238695686425 -0.6708123613041893 0.502340071717783 1.0 0.7184362644861467 30 Q6VMQ6,P19838,Q9H5I1,Q15910,Q09028,Q8WTS6,Q9BYW2,Q9UMN6,Q9NRG4,Q8TEK3,Q9BZ95,Q00653,Q04206 Rab geranylgeranylation -0.22917358661355486 -0.6706818727690738 0.5024232131507147 1.0 0.7184362644861467 39 P51159,O95755,P20336,Q12974,O14966,O95716,P26374,Q9H082,Q9NRW1 Costimulation by the cd28 family 0.1840518340494089 0.6688335190133686 0.5036016822991789 1.0 0.7194309747131128 23 P60953,P42345,P30154,P41240,P30153,P63000,Q14738,Q13177,P62993 Gaba receptor activation -0.3569922539290313 -0.6664686830088962 0.5051115744103032 1.0 0.7208967872330955 10 Q9HAV0,O60266,P62879 Signaling by activin -0.4394173403379634 -0.6537196720294527 0.5132924269089381 1.0 0.7318714986548495 5 Q13485,Q14919,P36896 G alpha z signalling events -0.3403433302629391 -0.6526003403761897 0.5140139660805025 1.0 0.7318888199642335 12 P62873,P62879,Q9HAV0,P17252,O60266,P05771 Activation of smo -0.4390922861294488 -0.6519833860279315 0.5144118901998314 1.0 0.7318888199642335 5 P32121,P49407,P25098 Autophagy -0.20168716919044796 -0.6513683531008444 0.5148087343858694 1.0 0.7318888199642335 93 P12931,Q96EY5,Q8TDY2,Q96B49,Q9UK41,O75143,Q70CQ3,Q0VGL1,Q8IVP5,Q9HB90,Q14596,A5D8V6,Q9NZ09,Q9Y484,Q14457,Q9UBN7,O43504,Q13099,Q9BY43,Q13404,P68366,Q9H1Y0,Q9UHA4,Q676U5,Q9Y478,Q9BQE3,Q99541,O95613 Rho gtpases activate cit 0.2685984923978363 0.6499787353413959 0.5157059575005909 1.0 0.7318888199642335 13 P62140,P61586,O43663,P60660,Q7Z406,P35580,P63000,P35579,Q15334 Linoleic acid la metabolism -0.459184134644688 -0.6494520035905874 0.5160462600309725 1.0 0.7318888199642335 4 P33897,O60427 Cytochrome c mediated apoptotic response -0.35442786092621953 -0.6484863987721065 0.5166704050681523 1.0 0.7318888199642335 10 Q9NQS1,Q96GX9,P98170,O14727,Q9BZF9,P55210 Interleukin receptor shc signaling -0.43841623988087813 -0.6483741601607966 0.5167429789277675 1.0 0.7318888199642335 5 O15357,P23458,P29353,O00459 Keratan sulfate keratin metabolism -0.3469874670238426 -0.6471647589108208 0.5175253167594023 1.0 0.7319466106060635 11 O60512,Q9Y274,Q11206,Q9NY97,P34059,P15291 Tbc rabgaps -0.24643501041459281 -0.6467924797852277 0.5177662601199939 1.0 0.7319466106060635 28 Q9ULP9,Q9HA65,Q9NZ52,Q96CV9,Q9H082,Q9NRW1 Mapk1 erk2 activation -0.437790982269086 -0.6450383813928732 0.5189023133643849 1.0 0.7328572956520696 5 P23458,P29597 Ras activation upon ca2 influx through nmda receptor -0.36388188692833695 -0.6407231371604104 0.5217025789944167 1.0 0.7354180158010226 9 Q92796,Q13555,Q14168,Q13557,P01111,P35609,Q12959,Q15334,P07196 Long term potentiation -0.36388188692833695 -0.6407231371604104 0.5217025789944167 1.0 0.7354180158010226 9 P12931,Q92796,Q13555,Q14168,Q13557,P35609,Q12959,Q15334,P07196 Regulation of signaling by cbl 0.3209373296649336 0.6382525413660962 0.523309300036717 1.0 0.736985687197267 8 P46109 Nostrin mediated enos trafficking 0.36978192446121216 0.6363150279439944 0.524571111872679 1.0 0.7380651149105683 2 Regulation of tp53 expression and degradation 0.22708848955413777 0.634624137427806 0.525673581858126 1.0 0.7389185254420827 17 P42345,Q93009,P04637,P30153 Ptk6 expression 0.3683933323236822 0.6296066104486108 0.5289519975116088 1.0 0.7424975363182162 2 Anchoring of the basal body to the plasma membrane -0.21106477813276436 -0.6292026948705731 0.529216364812044 1.0 0.7424975363182162 58 O75665,Q9BYV8,Q6NUS6,Q9UPN4,Q9P209,Q8NHV4,Q9NXR1,Q9UPM9,Q96QF0,P31323,P68366,Q99871,Q66GS9,P49674 Metabolic disorders of biological oxidation enzymes -0.3618230060602945 -0.6269051289797307 0.5307214250313443 1.0 0.7439086766667009 9 Q03154,P10109,O75881 Downregulation of erbb2 erbb3 signaling -0.4544572146455087 -0.625606583467752 0.5315730195411392 1.0 0.7444020668386254 4 Q9Y243,P31749 Cell extracellular matrix interactions 0.2911875929295898 0.622072054589239 0.5338944895243367 1.0 0.7469509759542363 10 Q14315,P05556,P12814,P21333 Abc transporters in lipid homeostasis -0.43285785366752705 -0.618800550486218 0.5360477595305531 1.0 0.7492600015952383 5 P33897,Q99758 Kinesins 0.13838760357484087 0.6176798992465552 0.5367863646151503 1.0 0.749589206444774 31 Q07866,Q9BUF5,P68371,Q9BW19,P33176,Q99661,Q14807,Q12756,O95235,O95239,Q9BVA1,P52732,Q9H0H5,Q13885,O00139,Q02241 Rac3 gtpase cycle -0.20989535255616412 -0.6147975995493132 0.5386883947657028 1.0 0.751540925281739 59 Q9UH65,Q8WUY9,Q9UHR4,Q5T5U3,Q9NYB9,Q15836,Q6ZW31,Q92558,O75044,P52735,Q9H2K8 Binding and uptake of ligands by scavenger receptors 0.27995711504269305 0.613781937252709 0.5393594348333115 1.0 0.7517732066432499 11 Q92598,Q9Y4L1,P14625,P07900,P27797 Fasl cd95l signaling -0.4219796396382034 -0.6126807891438969 0.54008742745506 1.0 0.751834300739097 3 Q13158 Transport of inorganic cations anions and amino acids oligopeptides -0.27129964819633495 -0.612189420556054 0.5404124403299146 1.0 0.751834300739097 20 Q8N697,Q9Y666,Q9UPY5,Q92581,Q8N8R3,Q9H2H9,Q01650,P52569 Mtor signalling -0.24861556196141307 -0.6062297359549562 0.5443622094317493 1.0 0.7563493917317301 25 Q9UHA4,O43504,Q9HB90,Q9Y478,Q9H9S4,Q0VGL1 The activation of arylsulfatases 0.3838363397527775 0.6057615802603817 0.5446730854551318 1.0 0.7563493917317301 3 Nef and signal transduction -0.42041590679721863 -0.6044534083010357 0.5455422366115716 1.0 0.7568509614071152 3 P06241 Runx2 regulates genes involved in cell migration -0.4486418420579192 -0.5964485990171086 0.5508755823404341 1.0 0.7631457633078204 4 Q13951,Q9Y243,P31749,P31751 Mecp2 regulates neuronal receptors and channels 0.2986281389712073 0.5961067422264705 0.5511039203484662 1.0 0.7631457633078204 9 P18031,Q96ST3,Q13451,Q13547,P51608,Q92769 Gap junction trafficking and regulation -0.2778125933253848 -0.5951345496483654 0.5517535357874477 1.0 0.7633359037356519 19 P17302,P68366,Q9BQE3,P36383 Egfr transactivation by gastrin -0.4478458964107094 -0.5924740619972088 0.5535331847149463 1.0 0.7650876115262245 4 P00533,P01111 Vegfr2 mediated vascular permeability 0.23679292208326433 0.5903350159124516 0.5549660681953805 1.0 0.7661110320813498 15 P42345,P35222,P07900,P14923,O60716,P35221 Regulation of commissural axon pathfinding by slit and robo -0.4176284795371065 -0.5898339844878611 0.5553019561395018 1.0 0.7661110320813498 3 P12931,Q9Y6N7 Rora activates gene expression -0.375284410015873 -0.5830611633424795 0.5598521267442158 1.0 0.7716740692404084 7 Q92793,Q09472,Q96RS0,Q9BZK7 Defects in vitamin and cofactor metabolism 0.2150716836586613 0.5803974781842809 0.561646605355119 1.0 0.7734320166165687 17 Q99707,Q96EY8,P11498,Q13085,Q96RQ3,P05165,P05166,Q9HCC0 Traf6 mediated induction of tak1 complex within tlr4 complex 0.37733812949643303 0.577895306468607 0.5633348042925639 1.0 0.7746754666128667 3 Q15750,Q6SZW1 Assembly and cell surface presentation of nmda receptors -0.2840682437032853 -0.5775182706305485 0.5635893998713741 1.0 0.7746754666128667 18 Q92796,Q13555,Q9NUP9,Q14168,P68371,Q13557,O14936,Q9BQE3,P68366,Q13509,P35609,Q12959,P04350,Q9BVA1,Q15334,P07196,Q13885 Netrin 1 signaling -0.26762407603017824 -0.5762066605574806 0.5644755037359261 1.0 0.7751783415359723 20 P12931,P45983,Q92859,Q05397,P06241,O00401,Q13153,O75962,P16333,Q9Y6N7 Metabolism of porphyrins 0.2524570446334491 0.5753320607214095 0.565066742478316 1.0 0.7752757332345219 13 P53004,P36551,P06132,P22830,P09601,P30519 Unblocking of nmda receptors glutamate binding and activation -0.36381638163815594 -0.5733277668047391 0.5664227882552324 1.0 0.7764213012882211 8 Q92796,Q13555,Q14168,Q13557,P35609,Q12959,Q15334,P07196 Tp53 regulates transcription of genes involved in g1 cell cycle arrest 0.3759479415914424 0.5720140711718026 0.5673124418312518 1.0 0.7768162014390282 3 P04637 Maturation of sars cov 2 spike protein 0.21291343981451838 0.5713630270964921 0.5677535861524172 1.0 0.7768162014390282 17 P27824,P46977,P39656,P04843,Q13724,Q14697,P14314 Platelet homeostasis -0.2586726794727022 -0.5689756940914493 0.5693726348978443 1.0 0.778316721098888 21 Q14571,P62873,Q13976,P04114,P62879,Q9HAV0,Q13362,Q13586,Q99487 Diseases of mismatch repair mmr -0.42259846805856943 -0.5647391088559293 0.5722512291231843 1.0 0.7815346758877585 5 P40692,P54278 Organelle biogenesis and maintenance -0.18749212044822366 -0.5630590952135429 0.5733946441046962 1.0 0.7823791389340635 159 O75665,Q9P209,Q99766,Q8WYA0,Q66GS9,Q6NUS6,P11474,Q16566,P30049,Q9NXR1,P16220,Q9UBN7,Q13099,Q3SYG4,Q8NHV4,Q9P2L0,Q9H5Q4,P68366,Q9UHN1,Q9NTG7,Q7Z494,P49674,P13196,Q8TCX1,Q9BYV8,Q9Y478,Q9UPN4,Q92793,Q9UPM9,Q96QF0,Q9BQE3,P31323,Q99871,P03928,O15379,Q96RK4 Pi3k events in erbb2 signaling -0.3816898220270178 -0.5541952127791818 0.5794452542252286 1.0 0.7894620327392045 2 P00533 Gastrin creb signalling pathway via pkc and mapk -0.34082876090134334 -0.553902933020053 0.579645277729322 1.0 0.7894620327392045 10 Q13164,P00533,P01111,P16220 Trafficking of ampa receptors 0.2272046153075309 0.5499186126249664 0.5823751974263327 1.0 0.7909592804861076 15 Q13555,P63010,O95782,O94973,P53680,Q96CW1,Q9UM54,P46459 Sars cov 2 infection -0.21845503266584604 -0.5489240641289193 0.5830575630207482 1.0 0.7909592804861076 42 Q9BY43,Q9BYF1,Q9BYC5,Q9UKM7,Q8IXQ6,Q9UKK3,Q09328,P07711 Negative regulation of mapk pathway 0.18770756038423927 0.548271692585879 0.5835053613932835 1.0 0.7909592804861076 19 P53041,Q14738,P30086,P30153 Dna damage telomere stress induced senescence 0.13830548222619687 0.5480434732144627 0.5836620526888943 1.0 0.7909592804861076 26 P49959,Q92878,P16403,P04637,P10412,P62805,P20700,P16402,P17096,P07305 Mismatch repair 0.21681170125953653 0.5476588328576704 0.5839261841557228 1.0 0.7909592804861076 16 P15927,P28340,P52701,P20585,P43246,Q9UQ84,P27694,Q9Y2S7,P12004 Runx3 regulates p14 arf -0.43881018882307476 -0.547653756923776 0.5839296701575292 1.0 0.7909592804861076 4 Q09472 Apoptotic factor mediated response -0.3043282324023307 -0.5451892181453856 0.5856233861558429 1.0 0.7925330112372442 15 Q9NQS1,Q07812,Q96GX9,P98170,O60443,O14727,Q16611,Q9BZF9,P55210 Tp53 regulates transcription of cell cycle genes 0.1352270790284518 0.5414880448540174 0.5881712356965241 1.0 0.7952587488092748 26 Q99873,P06748,P04637,P14635,Q86X55,A5YKK6,P06493,P12004 Adrenaline noradrenaline inhibits insulin secretion -0.36811278899570743 -0.5392548772135468 0.5897109992784808 1.0 0.7966177596780928 7 Q9HAV0,P62873,P62879 Response of eif2ak1 hri to heme deficiency 0.36497255725753236 0.5376321331830335 0.5908310415506475 1.0 0.7974078368754209 5 P08243,P05198 Sos mediated signalling -0.37792806422085373 -0.5337922294489403 0.5934852905070618 1.0 0.7978737963658807 2 P01111 Signaling by fgfr3 fusions in cancer -0.37792806422085373 -0.5337922294489403 0.5934852905070618 1.0 0.7978737963658807 2 P01111 Inhibition of dna recombination at telomere 0.2032729920055946 0.533734974381558 0.5935249080889831 1.0 0.7978737963658807 17 P62487,P30876,P16104,P62805,P24928,P19387,P19388,P62875 Scavenging by class a receptors -0.376670966519417 -0.5337023979748359 0.5935474498387614 1.0 0.7978737963658807 6 P02794,P02792,P04114 Signaling by leptin -0.4067237050144451 -0.5332598476257459 0.5938537182347394 1.0 0.7978737963658807 3 P51692 Free fatty acids regulate insulin secretion 0.3631876159178897 0.5308043563661763 0.5955543609296083 1.0 0.7994378358424472 5 O60488 Nucleotide salvage 0.25112162148603934 0.5298538340597182 0.5962132767417816 1.0 0.7996019643071598 12 P07741,P00491,P04183,P00492 Basigin interactions 0.26993055533749183 0.5286744529912129 0.597031302152411 1.0 0.7999789929919895 10 P08195,P54709,P05556 Platelet calcium homeostasis 0.32175044588565754 0.5259429981189582 0.5989278125495079 1.0 0.8017991380941301 6 P30626,P16615 Acyl chain remodelling of pc -0.41488748775399975 -0.5246190601865837 0.5998480340212309 1.0 0.8023102070840521 5 Q7L5N7,Q643R3 Interferon alpha beta signaling -0.3016577310431506 -0.5234925450647553 0.6006315375380418 1.0 0.8026376600284146 15 Q9Y6K5,P13747,P29597 Signaling by kit in disease -0.33621232175423627 -0.5221554515069785 0.6015621004429947 1.0 0.8031608688710234 10 P12931,P06241,P01111,P51692 Integrin signaling 0.2808739019770524 0.5200747824670039 0.6030114538477309 1.0 0.8036556943051154 9 P18031,Q9Y490,P62993 Platelet aggregation plug formation 0.2808739019770524 0.5200747824670039 0.6030114538477309 1.0 0.8036556943051154 9 P18031,Q9Y490,P62993 Rhot1 gtpase cycle -0.40354847241602565 -0.5169889886453519 0.6051638455423101 1.0 0.8050963398137605 3 Q96H55 Ion transport by p type atpases 0.19855513378582218 0.5169757492591848 0.6051730876452428 1.0 0.8050963398137605 17 P54709,P05023,Q9HD20,P30626,P16615 Interleukin 21 signaling -0.43144732589461654 -0.5115761076701147 0.6089477104841674 1.0 0.8086738757766573 4 P23458,P51692 Interleukin 9 signaling -0.43144732589461654 -0.5115761076701147 0.6089477104841674 1.0 0.8086738757766573 4 P23458,P51692 Post translational modification synthesis of gpi anchored proteins -0.3208430913349082 -0.5085515312884109 0.6110666100007436 1.0 0.8105465950215269 12 Q9Y2B2,Q92643,Q8TEQ8,Q6YHK3,O43292,Q5H8A4,Q9ULX3,Q969N2,Q96S52,P37287,Q9H490,O60762 Ephb mediated forward signaling 0.13041878438593296 0.5072378383117857 0.611987948593578 1.0 0.8105465950215269 24 P60953,P23528,P61158 Ncam signaling for neurite out growth -0.3137845437296273 -0.5072350870537508 0.6119898787914213 1.0 0.8105465950215269 13 P12931,P18433,Q05397,P06241,P01111,P16220,P13591 Aggrephagy 0.12913297158364798 0.5051907122889312 0.6134248930309967 1.0 0.8116215831878338 24 Q96FJ2,O43237,Q9BUF5,P68371,P07900,Q99497,P63167,P08670,Q13409,Q9BVA1,Q9Y6G9,P55072,Q14204,Q13885,P61088 Fbxw7 mutants and notch1 in cancer -0.4011034018830951 -0.5045271961814388 0.6138909558742878 1.0 0.8116215831878338 3 P62877 Regulation of tlr by endogenous ligand -0.400846682890365 -0.5032222814037857 0.6148080010460037 1.0 0.8121134056370084 3 P04114,O60443 Tp53 regulates transcription of caspase activators and caspases -0.410464401564255 -0.5018299917828237 0.6157871141914215 1.0 0.8126862711649406 5 P42575,Q13315,P55212,O14727 Rhoq gtpase cycle -0.21524303886770385 -0.49757198802286107 0.6187857516061486 1.0 0.8159210353036827 41 Q96RU3,Q658P3,O00308,Q9NRY4,Q8WUY9,Q9Y2X7,Q5T5U3,P17302,Q6ZW31,Q15642,O75044,Q15836 Mrna capping 0.13772155875283906 0.49520009371700674 0.6204588844793646 1.0 0.8174038354325847 22 O43148,O00267,P62487,P30876,O15514,P19447,P18074,P24928,P19387,P19388,Q09161,P62875 Tryptophan catabolism -0.39878815488487296 -0.49278332699690025 0.6221656927861423 1.0 0.8189264087025235 3 Q01650 Interleukin 3 interleukin 5 and gm csf signaling -0.2901047703375144 -0.49200778565463826 0.6227138396375564 1.0 0.8189264087025235 16 P23458,P06241,P29353,P51692 Met receptor recycling 0.29945237499520616 0.4896680973350838 0.6243687804669189 1.0 0.8203787327122656 7 P46109 Metalloprotease dubs -0.32459767755411745 -0.48741332465805826 0.6259654527373113 1.0 0.8214694541332194 11 Q99728,Q09472,Q96RL1,Q96FJ0 Cyclin a b1 b2 associated events during g2 m transition 0.1996081643490396 0.48693902321139565 0.6263015435539177 1.0 0.8214694541332194 16 P30154,Q9Y570,P53350,O14980,P14635,P63151,P06493,P30153 Tgf beta receptor signaling activates smads 0.2087007069759647 0.4830498776555214 0.6290603215839607 1.0 0.824362250800441 15 Q9Y5K5,O14980,Q9Y3F4,P61081,Q9UNE7,P62136 Downregulation of tgf beta receptor signaling 0.24751608683686513 0.47942360256557176 0.6316373057871458 1.0 0.8266274766752388 11 Q9Y5K5,O14980,Q9Y3F4,Q9UNE7,P62136 Suppression of apoptosis 0.309699478135705 0.47828517483395494 0.6324472466608675 1.0 0.8266274766752388 6 P49840,P28482,P27361,P23246,P14373 Recruitment of mitotic centrosome proteins and complexes -0.20134035543635057 -0.476458169197508 0.6337480018959192 1.0 0.8266274766752388 58 O75665,Q96RT7,Q9BYV8,Q9UPN4,Q96RT8,Q9P209,Q8NHV4,Q9NXR1,Q9UGJ1,P31323,Q99871,P68366,Q66GS9,P49674,O95613,Q9Y5B8 Signaling by flt3 itd and tkd mutants -0.4241444880020673 -0.47623582643933204 0.6339063784674666 1.0 0.8266274766752388 4 P01111,P51692 Stat5 activation downstream of flt3 itd mutants -0.39544768939764297 -0.47593934908270846 0.6341175878119449 1.0 0.8266274766752388 3 P51692 Stat5 activation -0.39544768939764297 -0.47593934908270846 0.6341175878119449 1.0 0.8266274766752388 3 P51692 Enos activation 0.3084631440303994 0.4735876368576746 0.6357939933673897 1.0 0.8280883305222122 6 P07900,O75608 Regulation of pyruvate dehydrogenase pdh complex 0.24560214865440458 0.4726019023841992 0.6364972249844618 1.0 0.8282802316391688 11 P11177,P08559,P10515 Inactivation of csf3 g csf signaling -0.3376804336431322 -0.46755987479928734 0.6400993649403195 1.0 0.8319048141509857 9 P23458,P29597,P51692 Interleukin 37 signaling -0.35612064487956985 -0.4671407104907391 0.6403992092826716 1.0 0.8319048141509857 7 Q9UHD2,Q12923,Q9H3S7,P43378,P17706 Alpha linolenic omega3 and linoleic omega6 acid metabolism 0.26647878325237595 0.4650291414983103 0.6419105878491647 1.0 0.8331417908495256 9 Q15067,P33121,P51659 Metabolism of steroid hormones 0.2784710088928297 0.46052493098675357 0.6451394807359585 1.0 0.8366038523033752 8 P22570,P15121,Q53GQ0 Signaling by csf3 g csf -0.31393085763448414 -0.4583814800065339 0.6466783947932324 1.0 0.8378702680364489 12 P23458,P29597,P29353,P51692 Tp53 regulates transcription of genes involved in g2 cell cycle arrest 0.21966248917657483 0.452982792277934 0.6505611324688658 1.0 0.8417019930774192 13 Q99873,P04637,Q86X55,P06493,P12004 Degradation of cysteine and homocysteine -0.33538007771873657 -0.45269890550287784 0.6507655678021389 1.0 0.8417019930774192 9 Q9Y6N5,Q96SZ5,O95571,Q99757 Maturation of sars cov 2 nucleoprotein -0.34447318620291667 -0.4518361482238962 0.651387026257932 1.0 0.8417750816342747 8 Q8IXQ6,Q9UKK3 Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 0.21809568492448717 0.44820205508263256 0.6540073797065995 1.0 0.8435814623656017 13 P04637,P06748 Assembly of the orc complex at the origin of replication -0.29911023457651303 -0.4476723342506287 0.6543896908958546 1.0 0.8435814623656017 14 Q8N257,O43929,Q9Y5N6,Q13415 Dna methylation -0.3528136526741183 -0.44754260122584577 0.65448333590244 1.0 0.8435814623656017 7 Q9UBC3,Q8N257 Met promotes cell motility 0.2278343273470057 0.44658331546321073 0.6551759444565524 1.0 0.8437443018498384 12 P05556,Q96N67,P46109,P62993 Amyloid fiber formation -0.3054898792098025 -0.4450424545211619 0.6562890738448419 1.0 0.84444794475718 13 Q9NZ52,Q8N257,Q92673 Cilium assembly -0.18713658753517556 -0.44104351732545843 0.6591814928929953 1.0 0.846663009952636 106 O75665,Q9P209,Q8WYA0,Q66GS9,Q6NUS6,Q9NXR1,Q9UBN7,Q13099,Q3SYG4,Q8NHV4,Q9P2L0,P68366,Q7Z494,P49674,Q8TCX1,Q9BYV8,Q9UPN4,Q9UPM9,Q96QF0,Q9BQE3,Q99871,Q96RK4 Ra biosynthesis pathway -0.36042181751361957 -0.44041060457446696 0.6596397457133345 1.0 0.846663009952636 6 O75911 Ovarian tumor domain proteases 0.19381614658536359 0.4403063095705928 0.6597152715134298 1.0 0.846663009952636 15 P04637,P55072,P06493,Q96FW1 Interleukin 2 family signaling -0.3412306698856322 -0.431892259876566 0.6658197205568848 1.0 0.8533062604585895 8 P23458,P29353,P51692 Formation of senescence associated heterochromatin foci sahf 0.20145304251256824 0.43137341606962676 0.6661968762467525 1.0 0.8533062604585895 14 P16403,P04637,P10412,P20700,P16402,P07305 Beta oxidation of very long chain fatty acids -0.3319716277572559 -0.43080560612563973 0.6666097229354351 1.0 0.8533062604585895 9 P33897,Q9NUI1,O95822 Aberrant regulation of mitotic g1 s transition in cancer due to rb1 defects -0.39627491240786 -0.42998409776459556 0.6672072089490506 1.0 0.8533379753940646 5 O00716 P130cas linkage to mapk signaling for integrins 0.35443024435095943 0.4291313745449638 0.6678276209123977 1.0 0.8533989323837672 4 Metabolism of ingested semet sec mesec into h2se 0.3386681690416038 0.42639476538349175 0.6698202150810308 1.0 0.8552117570443324 3 Ionotropic activity of kainate receptors -0.3845323741007028 -0.4217912408554393 0.6731773996518493 1.0 0.8580276522508601 3 Q15334,Q92796,Q12959 Nrcam interactions -0.3845323741007028 -0.4217912408554393 0.6731773996518493 1.0 0.8580276522508601 3 Q15334,Q92796,Q12959 Downregulation of erbb4 signaling -0.38219424460430007 -0.4103834281362469 0.6815247008404097 1.0 0.8679246190189833 3 P12931,P46934,Q96J02 Microrna mirna biogenesis 0.15204957498734403 0.40921309231871716 0.6823832872292812 1.0 0.8682759162866175 17 P62487,P30876,P24928,P62826 Mucopolysaccharidoses 0.2898854519777091 0.40760081114564867 0.6835667686980433 1.0 0.8690396632765227 6 P15586,P16278 Formation of the cornified envelope 0.23332568728642805 0.40149291772166146 0.6880572514053374 1.0 0.8732583514428898 10 Q14126,P14923,P15924 Keratinization 0.23332568728642805 0.40149291772166146 0.6880572514053374 1.0 0.8732583514428898 10 Q14126,P14923,P15924 Synthesis secretion and inactivation of glucagon like peptide 1 glp 1 -0.3267799121901492 -0.39776920993608794 0.6908003154408051 1.0 0.8752486989853738 9 Q9BY50,Q99626,P26367,P62873,Q3ZCW2 Incretin synthesis secretion and inactivation -0.3267799121901492 -0.39776920993608794 0.6908003154408051 1.0 0.8752486989853738 9 Q9BY50,Q99626,P26367,P62873,Q3ZCW2 Leishmania infection -0.19239921785280054 -0.396219085847082 0.6919434125846415 1.0 0.8759521535693423 73 Q14571,P19838,P45983,P05412,P06241,P31323,P62879,Q9HAV0,Q9NYB9,Q92558,Q00653,P16220,Q13459,P52735,P31321,P22694,P16885,O60266 Signal attenuation -0.38907486413066433 -0.3943614832307345 0.6933141763287156 1.0 0.87621499049801 5 Q13322,P29353 Bmal1 clock npas2 activates circadian gene expression -0.34371152032600544 -0.3943438899010947 0.6933271636222509 1.0 0.87621499049801 7 Q92793,Q96RS0,Q9UK39,Q9BZK7 Ketone body metabolism 0.2852258412812811 0.39246409680678096 0.6947153343906209 1.0 0.8766519704489769 6 P55809,P35914,P35610,P24752,Q9BUT1 Atf6 atf6 alpha activates chaperones -0.37828790813585733 -0.39148603912451396 0.6954380060877119 1.0 0.8766519704489769 3 P25208 Atf6 atf6 alpha activates chaperone genes -0.37828790813585733 -0.39148603912451396 0.6954380060877119 1.0 0.8766519704489769 3 P25208 Signaling by erbb4 -0.28496991405074046 -0.389834541478484 0.6966589000670398 1.0 0.8774411643309802 15 P01111,P46937,P49768,P00533,P29353 Proton coupled monocarboxylate transport -0.37778044136930833 -0.38904637922832086 0.6972418379650205 1.0 0.8774411643309802 3 Q6PCB8 Regulation of plk1 activity at g2 m transition -0.1947752325263406 -0.3852103035318405 0.7000816101708995 1.0 0.8802368434228667 62 Q9UKB1,O75665,Q9BYV8,Q9UPN4,Q9P209,Q9Y297,Q9NXR1,Q8NHV4,P31323,Q99871,P68366,Q66GS9,P49674,Q96CV9 Notch4 activation and transmission of signal to the nucleus 0.32644990023442194 0.3844500688339687 0.7006448968453154 1.0 0.8802368434228667 3 P63104 Cell cell junction organization 0.17717767292888537 0.3803940292662596 0.7036529460741439 1.0 0.883271179149515 14 P35222,P14923,P55196,P35221 Negative feedback regulation of mapk pathway -0.38578273327993823 -0.37828236511814006 0.7052208444159453 1.0 0.8844941567169685 5 P04049 Eph ephrin mediated repulsion of cells -0.24673782856277804 -0.37437308898389593 0.7081267615423585 1.0 0.8873918206039649 20 Q05193,P29317,P06241,P49768,P98172,P52735 Purine salvage 0.2371646308881319 0.3733250581887017 0.7089065286477381 1.0 0.8876224602396049 9 P07741,P00491,P00492 Methionine salvage pathway 0.2787837261500195 0.37251267375916813 0.7095111776008858 1.0 0.8876336310875902 6 P17174 Platelet sensitization by ldl 0.2500169372136791 0.369718050028122 0.7115925813307586 1.0 0.8894907266634483 8 P30154,Q14738,P30153 Signaling by pdgfra transmembrane juxtamembrane and kinase domain mutants 0.3140333080094154 0.36657020863087786 0.7139396336009272 1.0 0.890987509985905 5 P42224,P62993 Rho gtpases activate nadph oxidases -0.3070965417867343 -0.36650810693477487 0.7139859643779669 1.0 0.890987509985905 11 Q8NEB9,P28482,P27361,Q13526,P63000,Q16539,P17252,Q99570,Q05655,Q05513,P05771 Small interfering rna sirna biogenesis -0.34658988662947543 -0.3636314704350366 0.7161332232872524 1.0 0.8929192491196704 6 Q99598,Q15631,Q9UPY3,Q9UL18,O75569,Q15633 Pre notch processing in the endoplasmic reticulum -0.3721223021582576 -0.3620925292378756 0.7172828862135683 1.0 0.8936049334934922 3 Q8NBL1,Q9H488,Q04721 Map2k and mapk activation -0.24510258279449104 -0.3588472447789067 0.7197093670757855 1.0 0.8955762437876007 20 P27448,P12931,Q9UHA4,P32121,P04049,P01111,P10398,P49407,Q9BRX9 Rna polymerase i transcription termination -0.2523448773448714 -0.358368793181102 0.7200673423205004 1.0 0.8955762437876007 19 P17480,P32780,P51948,Q9GZS1,Q92759,Q15573,P61218,O15160,Q3B726,P18074,Q15361,O15446,P62875,P19447,O95602,Q9H9Y6,P19388,P50613,P52434 Cd28 dependent vav1 pathway 0.259103268112473 0.35595588894294966 0.7218735998958357 1.0 0.8970739481607967 7 P60953,Q13177,P62993 Hs gag degradation -0.3807641493593544 -0.3540406800295318 0.723308396833922 1.0 0.8981079260687865 5 Q9Y251,P51688 Uptake and actions of bacterial toxins 0.18765206563081535 0.3516372534322997 0.7251103230924769 1.0 0.8983204506558572 12 P07900,Q8WUM4,P13639 Sulfur amino acid metabolism -0.25878823396766637 -0.35157159294167195 0.7251595722960453 1.0 0.8983204506558572 18 Q96GX9,Q99757,Q9Y6N5,O95571,Q9UHY7,Q96SZ5,Q9UBK8 Regulation of bach1 activity -0.3443376101722552 -0.3514000345604271 0.725288256469125 1.0 0.8983204506558572 6 P62877,Q9BX63,O14867 Synaptic adhesion like molecules 0.22687563654838203 0.3479384412166135 0.7278864149259157 1.0 0.9001363410529314 9 Q14254,Q15334,O95197,O75955 Regulation of kit signaling -0.3355775123995334 -0.34783698581370254 0.7279626113884445 1.0 0.9001363410529314 7 P12931,P07947,P06241,P07948,P17252 Trafficking of myristoylated proteins to the cilium -0.3963364625523903 -0.3465798726653442 0.7289069690393923 1.0 0.9003338149574673 4 Q7Z494 Interleukin 4 and interleukin 13 signaling -0.2509865142111376 -0.3460158338698299 0.7293308152038007 1.0 0.9003338149574673 19 P37275,P14859,P23458,O43524,P29597,P01106 Hs gag biosynthesis -0.36816546762588376 -0.34352451069629714 0.7312039045939276 1.0 0.9014969416068465 3 O94923,Q93063,Q7LGA3 Carboxyterminal post translational modifications of tubulin -0.30361652687350915 -0.3430377002344059 0.7315700983318698 1.0 0.9014969416068465 11 Q9UPW5,P68366,Q14679,Q9BQE3 Gap junction degradation 0.23889845632275764 0.34113351280624415 0.7330030731896746 1.0 0.9014969416068465 8 Q9UM54,Q00610,Q96CW1,P50570 Cation coupled chloride cotransporters -0.3404064017263146 -0.340768301387566 0.7332780155005618 1.0 0.9014969416068465 2 P55011,Q9Y666 Acyl chain remodelling of ps -0.3674255341394902 -0.34007900111136696 0.7337970350184988 1.0 0.9014969416068465 3 Q643R3 Purinergic signaling in leishmaniasis infection 0.25302906024969735 0.33993800550997744 0.7339032148785938 1.0 0.9014969416068465 7 Q9Y2Z0,P09601 Rhobtb3 atpase cycle 0.2668788713422996 0.33869524335047174 0.7348393243571296 1.0 0.9016904730831665 6 Q13618 Growth hormone receptor signaling 0.23690395665252195 0.33642224671915966 0.7365524757020905 1.0 0.9016904730831665 8 P18031,P28482,P42224 Effects of pip2 hydrolysis -0.341397819759628 -0.33555983781699167 0.7372028143033529 1.0 0.9016904730831665 6 Q14571,P52429 Signaling by hippo 0.19101889418013449 0.33447170269121834 0.73802364053832 1.0 0.9016904730831665 11 Q07157,P62258,P31946 Disinhibition of snare formation 0.32146069436949665 0.3343306780880075 0.7381300432364091 1.0 0.9016904730831665 4 O00186,P17252,Q12846 Signaling by erbb2 in cancer -0.32482190448279913 -0.3333263032170381 0.7388879864657014 1.0 0.9016904730831665 8 P29353,P00533,P01111 Signaling by erbb2 ecd mutants -0.32482190448279913 -0.3333263032170381 0.7388879864657014 1.0 0.9016904730831665 8 P29353,P00533,P01111 Interleukin 7 signaling -0.37641445489092623 -0.33330765867788725 0.7389020588151318 1.0 0.9016904730831665 5 P23458,P51692 Pecam1 interactions -0.33279337652986984 -0.3321671270167715 0.7397630646789926 1.0 0.9020024274727487 7 P07947,P12931,P06241,P19174,P07948,P06756,Q06124 G0 and early g1 0.1889193904298448 0.33127196982721346 0.7404390619383863 1.0 0.9020884728439865 11 P12004 Smac xiap regulated apoptotic response -0.37491672369563817 -0.3262310052411957 0.7442495846812993 1.0 0.9047384768726733 5 O14727,P55210,P98170 Miro gtpase cycle 0.26203343939205526 0.32608442350990063 0.7443604817414422 1.0 0.9047384768726733 6 Q8IXI1,Q8IWA4,Q8IXI2,O95140 Cd163 mediating an anti inflammatory response 0.3071942446043345 0.32500006503948875 0.7451810224689677 1.0 0.9047384768726733 3 P35579,Q16539 Tp53 regulates transcription of several additional cell death genes whose specific roles in p53 dependent apoptosis remain uncertain -0.3312892950246498 -0.3237578859549149 0.7461213424028337 1.0 0.9047384768726733 7 Q13625,Q92597,P53611,Q53FA7,P24386 Vitamin b2 riboflavin metabolism -0.3638524741262869 -0.3235632883767924 0.7462686855620002 1.0 0.9047384768726733 3 Q969G6,P22413 Phase 0 rapid depolarisation -0.3634892086330783 -0.3218957145166612 0.7475316998673176 1.0 0.9047384768726733 3 Q13557,Q13555,Q9HD47 Flt3 signaling in disease 0.19690366310695695 0.3214107920749165 0.7478991057539701 1.0 0.9047384768726733 10 Q01082,P62993 Signaling by scf kit -0.26925006253329853 -0.3208449184504949 0.7483279174392661 1.0 0.9047384768726733 16 P06241,Q13322,P01111,P51692 Synthesis secretion and inactivation of glucose dependent insulinotropic polypeptide gip -0.37371039914090975 -0.32055510255734365 0.7485475663180874 1.0 0.9047384768726733 5 Q9BY50,P26367 Listeria monocytogenes entry into host cells 0.15907682317475946 0.3181200015255462 0.7503939121071896 1.0 0.9047384768726733 12 P35222,O60716,P62993 Mecp2 regulates transcription of neuronal ligands 0.3147639768484763 0.31777468065560405 0.7506558578593854 1.0 0.9047384768726733 4 Q96ST3,P51608 Constitutive signaling by ligand responsive egfr cancer variants -0.3220589590526227 -0.31716935978879485 0.7511150979137557 1.0 0.9047384768726733 8 P29353,P00533,P01111 Signaling by egfr in cancer -0.3220589590526227 -0.31716935978879485 0.7511150979137557 1.0 0.9047384768726733 8 P29353,P00533,P01111 Constitutive signaling by egfrviii -0.32205895905262266 -0.3171693597887943 0.7511150979137562 1.0 0.9047384768726733 8 P29353,P00533,P01111 Diseases associated with glycosaminoglycan metabolism 0.22646264626463625 0.3138075677371322 0.7536671963028108 1.0 0.9059607557095094 8 O95340,Q96L58,Q93063,P07686,P15291,P06865,Q8NCH0 Signaling by pdgf -0.2812415498414052 -0.3123128113994185 0.7548028045761104 1.0 0.9059607557095094 14 P12931,P51692,O43639,P01111,P20936,P16333 Downstream signal transduction -0.2812415498414051 -0.31231281139941736 0.7548028045761113 1.0 0.9059607557095094 14 P12931,P51692,O43639,P01111,P20936,P16333 Cell surface interactions at the vascular wall -0.2138864032110884 -0.3108678558260513 0.7559010818931662 1.0 0.9059607557095094 30 P12931,Q9BX67,Q9NRD5,Q9UPY5,P06241,P04114,P01111,P23229,Q01650,P29353 Tak1 activates nfkb by phosphorylation and activation of ikks complex -0.2870928790713244 -0.31075916251218644 0.7559837171485773 1.0 0.9059607557095094 13 P19838,O43318,Q13404,Q9Y6K9,O14920,P51617,Q00653,Q04206 Activated pkn1 stimulates transcription of ar androgen receptor regulated genes klk2 and klk3 0.2555551942029257 0.31027522792989776 0.7563516674620423 1.0 0.9059607557095094 6 P62805 Intra golgi traffic -0.2153431742305572 -0.30896307969152514 0.757349611820767 1.0 0.9059607557095094 29 Q9UP83,P33908,O14653,Q9Y2V7,O95755,Q9H082,Q9H9E3,P39880,O14662,O43752,Q15643,O60476,Q14746,Q8WTW3,Q96MW5,Q14964 Downregulation of erbb2 signaling 0.1881328830131155 0.30873195228198264 0.7575254359739982 1.0 0.9059607557095094 10 P07900,Q93034,Q16543 Dscam interactions -0.3709890954759716 -0.3078309501200586 0.7582109695973929 1.0 0.9059607557095094 5 P45983 Spry regulation of fgf signaling 0.22121211629276422 0.30371668514412925 0.7613437452192056 1.0 0.9059607557095094 8 P28482,P62993,P30153 Negative regulation of fgfr1 signaling 0.22121211629276422 0.30371668514412925 0.7613437452192056 1.0 0.9059607557095094 8 P28482,P62993,P30153 Negative regulation of fgfr4 signaling 0.22121211629276422 0.30371668514412925 0.7613437452192056 1.0 0.9059607557095094 8 P28482,P62993,P30153 Negative regulation of fgfr3 signaling 0.22121211629276422 0.30371668514412925 0.7613437452192056 1.0 0.9059607557095094 8 P28482,P62993,P30153 Negative regulation of fgfr2 signaling 0.22121211629276422 0.30371668514412925 0.7613437452192056 1.0 0.9059607557095094 8 P28482,P62993,P30153 Netrin mediated repulsion signals -0.3324941557273932 -0.30308087617029433 0.7618282277548931 1.0 0.9059607557095094 2 Q06124,P12931 Erythropoietin activates ras -0.3698451838565946 -0.3025160035187648 0.7622587355788899 1.0 0.9059607557095094 5 P29353,P01111 Recruitment of numa to mitotic centrosomes -0.18942464569017886 -0.30224369054893074 0.7624663004427683 1.0 0.9059607557095094 63 O75665,Q96RT7,Q9BYV8,Q9UPN4,Q96RT8,Q9P209,Q8NHV4,Q9NXR1,Q9UGJ1,P31323,Q9BQE3,P68366,Q99871,Q66GS9,P49674,O95613,Q9Y5B8 Diseases associated with o glycosylation of proteins -0.3857293274042403 -0.29959947190546177 0.7644826870396588 1.0 0.9076328316247743 4 Q9UHI8,Q14118,Q04721 Sialic acid metabolism -0.3106867739355566 -0.2981502796676798 0.7655884679546785 1.0 0.9082219882583367 9 Q11206,Q8TBE9,Q99519,Q9Y274 Synthesis of ketone bodies 0.28517452320978215 0.2945082851281911 0.7683695333872245 1.0 0.9107960260516821 5 P35610,P24752,P35914,Q9BUT1 Heme biosynthesis -0.317257692561146 -0.2894346863110694 0.7722487544778807 1.0 0.9134260751468158 8 P13196,Q9Y5Y0 The nlrp3 inflammasome 0.21274873957546286 0.2892011926176912 0.7724274192516698 1.0 0.9134260751468158 8 Q9Y2Z0,P09601 Inflammasomes 0.21274873957546286 0.2892011926176912 0.7724274192516698 1.0 0.9134260751468158 8 Q9Y2Z0,P09601 Cytosolic iron sulfur cluster assembly -0.2946597670250014 -0.2836916690318352 0.7766466796995037 1.0 0.917409945785178 11 O76071,Q9BX63,Q9NZ71,P53384,Q9Y3D0 Calnexin calreticulin cycle -0.2712284233132258 -0.2831944888930497 0.7770277527388554 1.0 0.917409945785178 15 Q9UKM7,Q9NYU1,Q86TM6,Q8WU17 Choline catabolism -0.35465553015522727 -0.2820313242730233 0.7779194915332024 1.0 0.9177355838356861 3 Q8WWI5,Q8NE62 Interleukin 6 signaling -0.3307472796938045 -0.27944694480919247 0.7799018486241007 1.0 0.9186195687351068 6 P23458,P29597 Interleukin 6 family signaling -0.3307472796938045 -0.27944694480919247 0.7799018486241007 1.0 0.9186195687351068 6 P23458,P29597 Regulation of localization of foxo transcription factors -0.2988765462166477 -0.27588915004489084 0.7826332076390945 1.0 0.9201748279290377 10 P31947,Q9Y243,O43524 Slbp dependent processing of replication dependent histone pre mrnas -0.3300027424653268 -0.27560387065977543 0.7828523364148119 1.0 0.9201748279290377 6 P62306,Q14493 Signaling by pdgfr in disease 0.1807706157724223 0.2753140719202632 0.7830749542375972 1.0 0.9201748279290377 9 Q6UN15,Q13439,O43815,O00459,Q8TAF3,P40763,P42224,P62993 Nuclear events kinase and transcription factor activation -0.2424949567495743 -0.2697173215294837 0.7873777336058239 1.0 0.9242545416643991 19 Q13164,P49137,Q99963,Q09472,P18846,P16220 Synthesis of pa -0.26275237352894176 -0.26918486294001076 0.7877874281300583 1.0 0.9242545416643991 16 O15120,Q643R3,Q9NRZ5 Transcriptional regulation by tp53 -0.16920832601059393 -0.262141049261617 0.7932127002688973 1.0 0.9298874298982353 222 Q658P3,O60563,Q9H9A7,Q9ULD4,Q96S44,Q9H160,Q9NRG4,Q15542,P78356,P51948,Q0VGL1,Q6P1X5,P40692,Q9UPQ9,P54278,Q9HB90,P28749,P05412,P29590,Q6R327,O60671,P00395,Q99638,Q13794,P55201,P31947,Q8IW41,Q5RI15,O43504,Q9P0S2,Q92794,Q92993,Q8NDV7,O14727,Q9UL18,Q9UHA4,Q8N0Z6,Q9Y478,Q92793,Q09472,Q15545,Q9Y243,P52564,Q53FA7,Q8N9N5,O00268,P50613,Q9ULM6 Rhoj gtpase cycle -0.19735083373125753 -0.26054980959174107 0.7944396990978837 1.0 0.9305936726854142 42 Q5T0N5,Q96RU3,Q658P3,O00308,Q9NRY4,Q8WUY9,Q9Y2X7,Q5T5U3,P17302,Q6ZW31,Q15836 Hdr through single strand annealing ssa -0.21084397074614097 -0.2578132900586048 0.796551007155617 1.0 0.9323338575505651 29 Q92889,Q06609,Q9H9A7,Q8WXE1,O60671,Q13535,Q9BX63,Q99728,Q13315,Q99638,Q92993,Q13472,Q14191 Trna modification in the mitochondrion 0.14968511715527635 0.2561982749182823 0.7977977406060415 1.0 0.9330601518861866 9 O75648,Q99714,O15091,Q9Y606,Q7L0Y3 Synthesis of pips at the er membrane -0.35931434233338566 -0.2545756666168922 0.7990508553028222 1.0 0.9331477053138869 5 Q8TCG2,O95248 Signal regulatory protein family interactions 0.2635840230298607 0.25326758312647846 0.8000614445425989 1.0 0.9331477053138869 5 Q05397,Q06124,Q08722,P62993 Sumoylation of transcription factors 0.1821782178217896 0.2530628327107102 0.800219659419237 1.0 0.9331477053138869 8 P61956,O75928,P04637,P42771,O75925,Q13330,Q12888 Beta oxidation of pristanoyl coa 0.2257736131175674 0.25285832331840535 0.8003776962356695 1.0 0.9331477053138869 6 P51659 Metabolism of vitamins and cofactors -0.1816347457535457 -0.2512415628075342 0.8016273523701083 1.0 0.933873928875263 86 Q5HYK3,P16260,P98164,P04114,O96007,P29374,Q9H3L0,Q9Y2Z9,P02656,P31749,P22413,Q9H999,Q15274,P35030,Q8IVH4,Q8IXQ6,Q6IA69,Q9BU02,Q9UBK8,Q05932,Q9Y4U1,Q9NZJ6,Q9UKK3,Q9Y5Z9,P42898,Q969G6,Q9NPF0,P09455,Q5EBL8,Q9NVS9,Q9NUN5,Q96EN8 Galactose catabolism 0.2800006368938013 0.24715011244561827 0.8047920522592229 1.0 0.9368282483330017 4 P51570 Mitochondrial biogenesis -0.19063154709195287 -0.24568178130994958 0.8059285764251527 1.0 0.9374188749988115 53 Q9Y478,P11474,Q92793,O15379,Q99766,Q16566,P30049,Q9H5Q4,Q9UHN1,Q9NTG7,P03928,P13196,P16220 Syndecan interactions 0.1602122812797168 0.23975501587824977 0.8105201820179635 1.0 0.9420242365107376 8 P05556 Triglyceride catabolism -0.28732291395542614 -0.23636519360932978 0.8131493025214394 1.0 0.9429387109627602 11 Q8WTS1,P41247,P22694 Loss of mecp2 binding ability to the ncor smrt complex -0.3703588877676083 -0.23447212820233382 0.8146184686157174 1.0 0.9429387109627602 4 Q9BZK7,O15379 Met activates ptk2 signaling -0.314605414935225 -0.23339871703042106 0.8154518093294707 1.0 0.9429387109627602 7 Q05397,P12931,P17301 Stat3 nuclear events downstream of alk signaling -0.32101961287718456 -0.23012786030761428 0.8179924164082799 1.0 0.9429387109627602 6 Q09472,O15379 Adenylate cyclase inhibitory pathway -0.3692923566806332 -0.23009459953543768 0.818018261268445 1.0 0.9429387109627602 4 O60266 Irs mediated signalling 0.1807055435565133 0.22946169144826278 0.8185100921118411 1.0 0.9429387109627602 7 Q8NEB9,O00459,Q99570,P62993,Q06124,P31751 Release of apoptotic factors from the mitochondria -0.36913113869400577 -0.22943456978304586 0.8185311698682964 1.0 0.9429387109627602 4 Q07812,Q9NR28,Q16611,O60443 Activated ntrk2 signals through frs2 and frs3 0.2668054178215522 0.22895854630745918 0.8189011355609475 1.0 0.9429387109627602 3 P62993 Frs mediated fgfr4 signaling 0.2668054178215522 0.22895854630745918 0.8189011355609475 1.0 0.9429387109627602 3 P62993 Frs mediated fgfr3 signaling 0.2668054178215522 0.22895854630745918 0.8189011355609475 1.0 0.9429387109627602 3 P62993 Frs mediated fgfr2 signaling 0.2668054178215522 0.22895854630745918 0.8189011355609475 1.0 0.9429387109627602 3 P62993 Frs mediated fgfr1 signaling 0.2668054178215522 0.22895854630745918 0.8189011355609475 1.0 0.9429387109627602 3 P62993 Lipophagy -0.32027672410851893 -0.22644397974206337 0.8208561252394011 1.0 0.944459943325643 6 Q99541,Q9Y478 Budding and maturation of hiv virion -0.23740204436050116 -0.22484050769370312 0.8221033521844494 1.0 0.9451651194095907 19 O75351,Q9H444,Q9UQN3,Q96EY5,Q9NZZ3,Q96FZ7,Q9H9H4,Q9BY43,A5D8V6,Q9UN37,O43633,Q96PU5,Q9UK41,Q9NZ09,Q9NP79,Q8WUX9,Q9Y3E7 Tie2 signaling -0.35131536555386866 -0.21944005888156767 0.8263072678944647 1.0 0.9492658667407498 5 P29353,P01111 Mtorc1 mediated signalling -0.2558236685932193 -0.21525103350519442 0.8295716043329688 1.0 0.9522285203937368 16 Q9UHA4,Q0VGL1,O43504,Q9HB90 Prevention of phagosomal lysosomal fusion 0.23489767550359936 0.2144908167424151 0.8301643275110497 1.0 0.9522285203937368 5 P51149,P20339,Q9H267 Nf kb activation through fadd rip 1 pathway mediated by caspase 8 and 10 -0.29582791633658534 -0.21076347719819263 0.8330718393087435 1.0 0.9548284927461753 9 Q13158,Q9Y6K9,Q9C037,Q14790 Nr1h2 nr1h3 regulate gene expression linked to lipogenesis 0.2544519086168645 0.20748097114456485 0.8356342521664089 1.0 0.9570292357632201 3 P49327 Glycogen storage diseases 0.22688017272399522 0.20661462649876938 0.8363108364487195 1.0 0.9570684687469985 5 Q04446,P46976,P13807,P10253 Mitochondrial iron sulfur cluster biogenesis -0.31563793413712093 -0.20372154473250098 0.8385711049920166 1.0 0.9589186081643167 6 Q9Y697,Q9H1K1,Q86U28,Q86SX6,P10109,P22570 Type i hemidesmosome assembly 0.24928057553957916 0.19955016611091878 0.8418324054475976 1.0 0.961909727083528 3 Q03001,Q15149 Vitamin b5 pantothenate metabolism -0.2859998083587918 -0.1971380039532527 0.8437195440833829 1.0 0.9633272955434793 10 P22413,Q5EBL8,P16260,Q9H999 Peroxisomal lipid metabolism -0.2275142356886533 -0.19589356082086087 0.8446934773480979 1.0 0.9635403444202584 20 A8MXV4,O95822,P43155,P33897,Q9NUI1 Pyrimidine salvage 0.238711998560899 0.19524713158505766 0.845199483327032 1.0 0.9635403444202584 4 Q08623,P04183,Q9BZX2 Triglyceride metabolism -0.27486887990377895 -0.18992832363564052 0.8493652973679118 1.0 0.967549153729502 12 Q8WTS1,P41247,P22694 Activation of irf3 irf7 mediated by tbk1 ikk epsilon -0.33255395683451927 -0.18871154368823934 0.8503189035987087 1.0 0.9678954670451306 3 Q9UHD2,Q06124,Q6SZW1 Semaphorin interactions -0.19818390686547258 -0.18296432420730252 0.854826011206324 1.0 0.9716357243059881 33 P51805,Q9NZN5,P06241,O15085,Q14194,P08134 Regulation of pten localization -0.35745662610980394 -0.1828585376056064 0.8549090164866782 1.0 0.9716357243059881 4 P29590 Negative regulation of the pi3k akt network -0.2093038230710257 -0.18192620890913108 0.8556406359753312 1.0 0.9717260271366185 25 P12931,P06241,P31749,O60346,P48426,P78356,Q13362,Q9Y243,P00533,P51617 Rnd1 gtpase cycle -0.2065862981709934 -0.17982184588756184 0.8572924326359737 1.0 0.9728604147963448 27 Q8WUY9,P29317,Q9UIW2,Q3V6T2,Q12923,Q9NRY4,Q9UJF2,Q99569,Q9ULK5 Dissolution of fibrin clot -0.3557793330666979 -0.17637221542929127 0.8600015313530414 1.0 0.974408601695574 4 P50452 Activation of ppargc1a pgc 1alpha by phosphorylation -0.35563950350782136 -0.17583389065212227 0.8604244435334092 1.0 0.974408601695574 4 P54619,P54646,Q16539,Q9Y478 Signaling by mras complex mutants -0.30974582539740053 -0.17558676104249185 0.8606186039136747 1.0 0.974408601695574 6 P04049,P36873,P10398 Synthesis of leukotrienes lt and eoxins ex 0.20489296636086257 0.17379363719210714 0.8620276450829343 1.0 0.9751392103783707 4 P33527,P09960,Q14914 O linked glycosylation of mucins -0.30278908180917496 -0.17310002552925577 0.8625728048850285 1.0 0.9751392103783707 7 Q11206,Q9NY97 Regulation of ifng signaling -0.3026071031327151 -0.17219826005466707 0.8632816657254989 1.0 0.975200668636083 7 P23458,P15260,P17706 Foxo mediated transcription of oxidative stress metabolic and neuronal genes -0.2956850380322163 -0.17099461541667074 0.8642279995162694 1.0 0.9755300903630616 8 P04150,Q9NTG7,Q13485,O43524 Sema3a pak dependent axon repulsion -0.2765525363724951 -0.16933765453075383 0.865531059604441 1.0 0.9762613768437676 11 P51805,P06241 Receptor mediated mitophagy -0.3015011506598545 -0.166736292454751 0.8675775479955241 1.0 0.9778294602975272 7 P12931,Q9H1Y0,Q8IVP5,P68400 Loss of function of mecp2 in rett syndrome -0.2862801584443621 -0.1574581167462766 0.8748838140764319 1.0 0.9853188835781432 9 P17612,O75376,Q96ST3,Q16566,Q13547,Q9BZK7,P17252,P51608,O15379 Class a 1 rhodopsin like receptors -0.2736316621125456 -0.15171992801112477 0.8794078388507636 1.0 0.9880886438138899 11 Q3ZCW2,P22466,Q9UK39,Q9ULM6 Peptide ligand binding receptors -0.2736316621125456 -0.15171992801112477 0.8794078388507636 1.0 0.9880886438138899 11 Q3ZCW2,P22466,Q9UK39,Q9ULM6 Regulation of ifna signaling -0.33488094982223154 -0.15113410096550994 0.8798699327728763 1.0 0.9880886438138899 5 P23458,P29597 Sema4d in semaphorin signaling -0.26376063102557307 -0.15097463474675146 0.8799957250610952 1.0 0.9880886438138899 13 P08134,Q9NZN5,O15085 Transcriptional regulation by mecp2 -0.20362610851808552 -0.14832787748036305 0.8820840156482148 1.0 0.9896288442299421 27 Q9UPQ9,O15379,Q16566,Q8NDV7,Q9UL18,P16220,P51617,Q7Z2K8 Synthesis of pips at the golgi membrane -0.2681760270534225 -0.14755268946645939 0.8826957946185188 1.0 0.9896288442299421 12 Q8TCG2,Q9Y2I7 Egfr downregulation -0.2630362884247503 -0.14625878199642842 0.88371710308768 1.0 0.9896415337633304 13 Q99963,P00533,O75886 Prc2 methylates histones and dna -0.2675359310704989 -0.14357127848996531 0.8858390220876624 1.0 0.9896415337633304 12 Q9UBC3,Q8N257 Diseases associated with glycosylation precursor biosynthesis -0.25742440005721856 -0.14284826064696962 0.8864100214014794 1.0 0.9896415337633304 14 Q9UPQ8,Q96E22,Q14376,O15305,Q99519,Q86SQ9 Mitochondrial fatty acid beta oxidation -0.20306799723562727 -0.1424287397940368 0.886741362715072 1.0 0.9896415337633304 27 Q86TX2,Q6JQN1,Q9BR61,Q16698,Q9BV79,Q8IVH4,Q96CM8,Q96PE7,P07108,O14561 Interleukin 35 signalling -0.3326674584774029 -0.1423656968386783 0.8867911563164026 1.0 0.9896415337633304 5 P23458,P29597 Interleukin 27 signaling -0.3326674584774029 -0.1423656968386783 0.8867911563164026 1.0 0.9896415337633304 5 P23458,P29597 Pregnenolone biosynthesis -0.302350577326457 -0.14149880709125442 0.8874759023650982 1.0 0.9896415337633304 6 P10109 Formation of incision complex in gg ner -0.20412740121870498 -0.140809263724213 0.8880206245916595 1.0 0.9896415337633304 26 P23025,P62877,Q01831,Q15819,P51948,P50613 Meiotic recombination -0.22102279492746663 -0.13815723079657283 0.8901161557559323 1.0 0.9908493004127394 20 Q8N257,P40692,Q06609,O43502,Q9BWT6 Zbp1 dai mediated induction of type i ifns -0.2756549320546857 -0.1370366030712281 0.8910018629511873 1.0 0.9908493004127394 10 Q9UHD2,P19838,Q9Y6K9,Q00653,Q04206 Signaling by ntrk2 trkb -0.28235615954236837 -0.13628233338018714 0.8915980894959152 1.0 0.9908493004127394 9 P12931,P06241,P29353,P01111 Acyl chain remodelling of pg -0.31884211862939227 -0.1360719898937883 0.8917643703714655 1.0 0.9908493004127394 3 Q643R3 Neurotransmitter release cycle -0.26959322532195085 -0.12779016866790813 0.8983150305385224 1.0 0.9970232982191591 11 O14795,P20336,Q9NUP9 Runx1 interacts with co factors whose precise effect on runx1 targets is not known -0.20396480475214102 -0.12735522268572472 0.8986592547035777 1.0 0.9970232982191591 25 O95503,Q09472,O00257,P35226,Q06587,Q8NFD5 Mapk3 erk1 activation -0.29860904628031887 -0.12480069355911377 0.9006813383053385 1.0 0.9985232098771982 6 P23458,P29597 Caspase activation via death receptors in the presence of ligand -0.32739955064283605 -0.12193662555197253 0.9029492090469731 1.0 0.9995500159583878 5 Q13158 Regulation by c flip -0.32739955064283605 -0.12193662555197253 0.9029492090469731 1.0 0.9995500159583878 5 Q13158 Synthesis of udp n acetyl glucosamine -0.29751524626104825 -0.11999135000233728 0.904490000148201 1.0 1.0 6 O94808 Creb1 phosphorylation through nmda receptor mediated activation of ras signaling -0.2539196251576887 -0.11932652675914104 0.9050166683246665 1.0 1.0 14 P51812,Q92796,Q13555,Q14168,P28482,Q13557,P01111,P27361,P07196,P35609,Q12959,P16220,Q15334,Q15418 Amino acids regulate mtorc1 -0.20495794419010568 -0.11629869993272371 0.9074158159254546 1.0 1.0 23 Q9UHA4,O43504,O75348,Q9HB90,Q9P0V3,Q9Y664,Q0VGL1 Gp1b ix v activation signalling -0.3394244583270212 -0.11604488341235508 0.9076169702399588 1.0 1.0 4 P04049 Polo like kinase mediated events -0.2778177889809124 -0.112363236585972 0.9105354036401883 1.0 1.0 9 P30307,Q09028,P53350,Q5TKA1,Q09472,P14635,Q99640,P49454,O95067 Tnfr1 induced nfkappab signaling pathway -0.2622908035491558 -0.11144589904748375 0.9112627645496802 1.0 1.0 12 Q96EP0,O43318,P98170,Q9Y6K9,Q12933,O14920,Q13107 Gaba synthesis release reuptake and degradation -0.3374606926186834 -0.1091742491861196 0.9130642843774426 1.0 1.0 4 P20336 P75ntr negatively regulates cell cycle via sc1 -0.3111976402908814 -0.1086687857766698 0.9134652005419266 1.0 1.0 3 O15379 Rna polymerase iii transcription initiation from type 3 promoter -0.2598248033657881 -0.09666225525780595 0.9229946153568482 1.0 1.0 12 P62875,Q9BUI4,P14859,P61218,Q9NVU0,O15160,O75575,Q9NW08,P19388,Q9H1D9,P52434 Downstream signaling of activated fgfr3 -0.31969016897514335 -0.09319502882963687 0.9257486236222445 1.0 1.0 5 P29353,P01111 Downstream signaling of activated fgfr4 -0.31969016897514335 -0.09319502882963687 0.9257486236222445 1.0 1.0 5 P29353,P01111 Downstream signaling of activated fgfr1 -0.31969016897514335 -0.09319502882963687 0.9257486236222445 1.0 1.0 5 P29353,P01111 Downstream signaling of activated fgfr2 -0.31969016897514335 -0.09319502882963687 0.9257486236222445 1.0 1.0 5 P29353,P01111 Non integrin membrane ecm interactions -0.2588874646715161 -0.0910987946708697 0.9274140903753361 1.0 1.0 12 P11532,P17301,P23229,P17252,P06756,Q14118 Rnd3 gtpase cycle -0.1967623249507392 -0.08874523600594711 0.9292843812041784 1.0 1.0 28 Q8WUY9,P29317,Q9NRY4,Q3V6T2,Q12923,Q9UJF2,Q5T5U3,Q99569,Q9ULK5 Pre notch processing in golgi -0.27903640582968825 -0.0878986875896298 0.929957199720175 1.0 1.0 8 P15291,Q11206,Q9Y274 Fanconi anemia pathway -0.24663332447714 -0.0718366493202586 0.9427319062111563 1.0 1.0 14 O15360,Q92889,Q8WXE1,Q13535,Q9NPD8,O15287,Q8TAF3,O94782 Sema4d mediated inhibition of cell attachment and migration -0.32577801762906655 -0.07005792198477491 0.9441475577633625 1.0 1.0 4 Q9NWH9,P63000,Q9NRY4,P61586 Dex h box helicases activate type i ifn and inflammatory cytokines production -0.3130333461264687 -0.06953053509006808 0.9445673279737363 1.0 1.0 5 Q00653,P19838 Regulation of cytoskeletal remodeling and cell spreading by ipp complex components -0.32110158983124004 -0.0552712262225341 0.9559223852617365 1.0 1.0 4 Q9NVD7,P49023 Translation of sars cov 2 structural proteins -0.19542476911870002 -0.05239420775042051 0.958214589325457 1.0 1.0 26 Q11206,Q9BYC5,Q9UKM7,Q8IXQ6,Q9UKK3,Q09328,Q10469 Adp signalling through p2y purinoceptor 12 -0.2705988789183977 -0.04905490588713792 0.9608755400010105 1.0 1.0 8 Q9HAV0,P62879 Nucleotide binding domain leucine rich repeat containing receptor nlr signaling pathways -0.19839091180626084 -0.04603096305974036 0.9632855711052735 1.0 1.0 22 P19838,O43318,O15111,Q15750,P42575,Q13685,Q9Y6K9,Q16539,Q14790,P05067,Q13404,Q96J02,O14920,P61088,Q00653,Q96RD7,P52564,P51617,Q04206 Nuclear signaling by erbb4 -0.2688954195617664 -0.04150198320840607 0.9668957118462609 1.0 1.0 8 P12931,P49768,P78536,P46937 Rhov gtpase cycle -0.192129651068222 -0.04049427714676371 0.9676990694764185 1.0 1.0 28 B2RTY4,Q8IW35,Q8WUY9,P29317,Q9Y2X7,O43639,Q7Z6J0,P16333,Q8IWW6 Egr2 and sox10 mediated initiation of schwann cell myelination -0.24986115904425094 -0.03918704825152515 0.9687412597038916 1.0 1.0 12 P28347,Q86SK9,P46937 Synthesis of bile acids and bile salts -0.24833542096990383 -0.03072429841108616 0.9754894129778715 1.0 1.0 12 O95342,O75881 Bile acid and bile salt metabolism -0.24833542096990383 -0.03072429841108616 0.9754894129778715 1.0 1.0 12 O95342,O75881 Tp53 regulates metabolic genes -0.17274704935445612 -0.03000729415984826 0.976061235893249 1.0 1.0 59 Q9UHA4,Q5RI15,O43504,Q9UPQ9,Q9P0S2,Q9HB90,Q9Y478,Q8NDV7,Q9Y243,P00395,Q9UL18,P31947,Q0VGL1 Signalling to erks -0.22441295068912376 -0.026235166102986766 0.9790697670344026 1.0 1.0 17 P12931,Q16644,P49137,P01111,P11234,P29353 Regulation of tp53 activity through phosphorylation -0.17162053936675778 -0.012040930815593948 0.9903929593496572 1.0 1.0 58 P68400,Q9H9A7,Q96S44,Q15542,Q9BX63,Q13315,Q99728,Q6P1X5,O60671,Q99638,P49848,Q8IW41,Q9HBM6,Q12962,Q13535,Q92993,Q13472,Q14191,Q9Y478,Q8WXE1,Q15545,O00268 Class i peroxisomal membrane protein import -0.22699246890991534 -0.008128118158079397 0.993514771422547 1.0 1.0 16 Q92968,Q9Y6I8 Synthesis of pc -0.2506116287919003 -0.005993707083715508 0.9952177422893349 1.0 1.0 10 Q9Y6K0,P68400,P49585,Q8IWA5,Q8WWI5 Noncanonical activation of notch3 -0.2755395683453145 -0.0011248959590767127 0.9991024630710323 1.0 1.0 3 Q92542,P49768,P67809 Aflatoxin activation and detoxification -0.26701224713529853 -0.00027005140516456227 0.999784530155815 1.0 1.0 6 Q9UJ14,P10620,Q03154 Membrane trafficking -0.09958901187447027 0.0 1.0 1.0 1.0 405 Q8WXG6,P08174,Q96CN9,Q99963,P04114,Q9BTE1,Q0JRZ9,Q9Y5R8,Q9Y3Q3,Q8IWF6,Q147X3,O00189,O95208,Q8NI22,P14672,Q86VX9,O95755,P20336,O43426,Q9NY64,Q9UL33,Q9NZ52,P17302,Q86TI0,O00399,P31947,Q9NRW1,Q9HA65,Q9BY43,Q6ZUT9,P36383,Q9Y6B7,P68366,Q2PPJ7,Q15836,Q9UPM8,Q5T0N5,P51159,O94955,P02794,A5PLN9,Q96QF0,Q9UBR2,P25098,Q9BQE3,Q16890,Q86SZ2,P49418,P39880,Q8WVT3,Q96CV9 Assembly of collagen fibrils and other multimeric structures -0.2911186712871134 0.0 1.0 1.0 1.0 5 P23229,P07858,P07711 Wnt mediated activation of dvl -0.2770187946374188 0.0 1.0 1.0 1.0 5 P49674 Role of phospholipids in phagocytosis -0.2136778027333641 0.0 1.0 1.0 1.0 7 Q14571,P16885 Generation of second messenger molecules -0.2401440144014356 0.0 1.0 1.0 1.0 8 Q16512,P50552,Q8N8S7,P19174,Q13153,Q13177,P16885,P16333 Intracellular signaling by second messengers -0.15417964833170528 0.0 1.0 1.0 1.0 141 O00257,P78356,Q0VGL1,Q96RR4,Q9UPQ9,Q9HB90,P05412,P29590,Q16566,O60346,Q6R327,P16220,O43504,P06241,Q8NDV7,Q9UL18,P00533,Q9UHA4,O95503,O00308,P31323,O43524,P25098,Q9Y243,P35226,O15379,P31321,P22694,O60266,Q92995 Vitamin d calciferol metabolism -0.2551304425142009 0.0 1.0 1.0 1.0 6 P98164,Q8N2W9 Hemostasis -0.09364780289409265 0.0 1.0 1.0 1.0 200 Q14571,P62328,Q9ULD4,P04114,P08962,P49407,Q8WZ42,Q99487,Q05513,O43572,P52735,P29353,P52429,Q8TDN4,Q9NRD5,Q9BX67,Q9BX10,P50452,Q6YHK3,Q92908,P04049,Q13976,P06241,P01111,P17301,P23229,Q9HAV0,P68366,P62879,Q02224,Q92845,P50148,Q9UPY5,O43502,P31323,Q8NI77,Q9BQE3,Q96HP0,P22694,Q01650,P31321,P16885,O60245 Intrinsic pathway for apoptosis -0.16417481314443022 0.0 1.0 1.0 1.0 35 Q9NQS1,P45983,Q96GX9,P98170,Q13625,O60443,P31749,Q9Y243,O14727,Q13794,P31947,Q9BZF9,Q14790 Recognition and association of dna glycosylase with site containing an affected purine -0.2635189468934542 0.0 1.0 1.0 1.0 6 Q8N257 Raf independent mapk1 3 activation -0.20212342014077217 0.0 1.0 1.0 1.0 9 P29597 E2f mediated regulation of dna replication -0.15701108082136 0.0 1.0 1.0 1.0 17 O43929,Q9Y5N6,Q9UJA3,Q13415 Activation of bh3 only proteins -0.19064720415218858 0.0 1.0 1.0 1.0 17 P31947,Q9Y243,Q13794,P45983 Transcription of e2f targets under negative control by dream complex -0.2529532927841706 0.0 1.0 1.0 1.0 8 Q99741,Q09028,P28749,Q5TKA1,P01106 Transcription of e2f targets under negative control by p107 rbl1 and p130 rbl2 in complex with hdac1 -0.2503758747728748 0.0 1.0 1.0 1.0 6 P28749,Q5TKA1,P20248,Q09028 Extracellular matrix organization -0.1453878113624061 0.0 1.0 1.0 1.0 50 Q9UHI8,Q9BX67,P14543,P11532,Q13332,Q13443,Q8IVL6,P17301,Q9Y6W3,P23229,P49768,O15484,P13591,P07711 Synthesis of pg -0.25683759421284147 0.0 1.0 1.0 1.0 5 Q32NB8 Glycerophospholipid biosynthesis -0.12053816482054049 0.0 1.0 1.0 1.0 51 Q32NB8,Q99447,P68400,Q9NRZ5,P49585,Q9Y6K0,Q8IWA5,Q9C0D9,Q9HBU6,Q96AD5,Q7L5N7,O94830,O15120,Q643R3,Q8WWI5 Gamma carboxylation hypusine formation and arylsulfatase activation -0.17547781998634682 0.0 1.0 1.0 1.0 15 Q9BTV6,Q7L8W6 Sphingolipid de novo biosynthesis -0.2143451634622715 0.0 1.0 1.0 1.0 18 Q6ZMG9,Q9HA82,O94806 Signaling by ntrks -0.15826213456310406 0.0 1.0 1.0 1.0 51 Q05193,Q13164,Q16644,Q13332,Q99963,P06241,Q09472,P01111,P18846,P16220,P29353 Transcription of the hiv genome -0.16543541326341735 0.0 1.0 1.0 1.0 50 O60563,O60942,P52655,Q15542,P51948,Q92759,Q6P1X5,P61218,P29084,P49848,Q9HBM6,Q12962,P52657,Q9Y5B0,Q15545,O75909,P52298,O00268,P50613 Signaling by flt3 fusion proteins -0.24796902854327643 0.0 1.0 1.0 1.0 8 P01111,P51692,Q15643 Activation of atr in response to replication stress -0.15475903745986885 0.0 1.0 1.0 1.0 34 Q8WXE1,O43929,Q9Y5N6,Q9UJA3,O60671,Q99638,O00311,Q13415 Darpp 32 events -0.2252133377321217 0.0 1.0 1.0 1.0 13 P31321,P22694 Gab1 signalosome -0.25892767969379704 0.0 1.0 1.0 1.0 6 P12931,P00533,P49023 Rnd2 gtpase cycle -0.14870225412981608 0.0 1.0 1.0 1.0 27 Q96RU3,Q8WUY9,P29317,Q9NRY4,Q12923,Q99569,Q9ULK5 Rip mediated nfkb activation via zbp1 -0.23902495055207157 0.0 1.0 1.0 1.0 9 Q00653,P19838,Q04206,Q9Y6K9 Cytosolic sensors of pathogen associated dna -0.16226668393660057 0.0 1.0 1.0 1.0 34 Q9UHD2,P19838,Q32MZ4,Q92793,Q09472,Q9Y6K9,Q9NVU0,O75575,Q9BRZ2,Q00653,P61218,Q04206,Q9H1D9,Q13049 Signaling by cytosolic fgfr1 fusion mutants -0.20648903235463503 0.0 1.0 1.0 1.0 12 P39880,P51692 Fgfr1 mutant receptor activation -0.17931910583603372 0.0 1.0 1.0 1.0 14 O95684,O15164,Q16630,O94905,Q32MZ4,P11274,P51692,Q9UBW7,Q92614,P40763,P42224,O95429,P39880 Translation of sars cov 1 structural proteins -0.23882959042500657 0.0 1.0 1.0 1.0 11 Q11206,Q8IXQ6,Q9UKK3 Metabolism of water soluble vitamins and cofactors -0.13762012258739903 0.0 1.0 1.0 1.0 64 P16260,O96007,Q9H3L0,Q9H999,P22413,Q15274,P35030,Q8IVH4,Q8IXQ6,Q6IA69,Q9BU02,Q9UBK8,Q05932,Q9Y4U1,Q9UKK3,P42898,Q969G6,Q9NPF0,Q5EBL8,Q9NVS9,Q9NUN5,Q96EN8 Integrin cell surface interactions -0.2246474627636436 0.0 1.0 1.0 1.0 8 P23229,Q9BX67,P17301 Synthesis secretion and deacylation of ghrelin -0.2949011485502155 0.0 1.0 1.0 1.0 4 Q9BY50 Signaling by type 1 insulin like growth factor 1 receptor igf1r -0.18978535486212503 0.0 1.0 1.0 1.0 10 Q8NEB9,P08069,P01111,P29353 Rna polymerase i transcription -0.12366104717734311 0.0 1.0 1.0 1.0 40 Q8N257,Q15361,Q92830,P51948,Q9NYV6,Q15573 Rna polymerase ii transcription -0.12605926410703056 0.0 1.0 1.0 1.0 520 O94913,Q658P3,Q06609,Q92989,O00257,P46937,Q9UHV7,Q9UPQ9,Q9HB90,Q7Z7C8,Q16566,P25208,Q13794,P16220,Q9UBN7,Q15561,Q92993,O14727,Q9UHA4,Q8N257,Q8N0Z6,Q9Y243,Q53FA7,Q9ULD4,Q9ULM6,Q9H160,Q9NRG4,Q15542,Q96SI1,P54278,P11474,P62877,P31947,Q9H7S9,Q5RI15,Q8IXW5,O43504,Q92794,P28347,Q9UL18,P52657,P01106,Q14493,P62306,P08047,Q92793,P35226,Q92830,P52564,O15379,O00268,Q9UPW6,O60563,Q9Y3C7,P52655,P78356,Q9BYE7,O60671,P00395,Q99638,P55201,Q8IW41,P14859,P24863,Q8NDV7,Q9NTG7,O95503,Q09472,Q15545,Q8N5P1,Q9UMN6,Q8N9N5,Q6I9Y2,P07711,P19838,Q9H9A7,Q96S44,P49336,P51948,Q0VGL1,Q6P1X5,Q8NFD5,Q9UM13,P40692,Q03111,P28749,P05412,P29590,Q6R327,Q6P2C8,Q9P0S2,Q8WVC0,Q86U70,P00533,Q9UL03,P28702,Q9Y478,O43524,P50613,Q9H0L4,Q9UGL1 Rna polymerase iii chain elongation -0.2422499768444343 0.0 1.0 1.0 1.0 11 P62875,Q9BUI4,P61218,Q9NVU0,O15160,O75575,Q9NW08,P19388,Q9H1D9,P52434 Rna polymerase i promoter escape -0.169783261909016 0.0 1.0 1.0 1.0 24 Q8N257,P51948,Q9NYV6,Q15573,P50613 Rna polymerase i transcription initiation -0.16186606542609813 0.0 1.0 1.0 1.0 34 Q12873,Q92769,P17480,P32780,P51948,Q9GZS1,Q92759,Q15573,P61218,Q16576,Q8WXI9,Q13547,O15160,Q9BTC8,Q3B726,Q86YP4,Q96KQ7,Q09028,P18074,Q15361,Q9NYV6,O15446,O95983,P62875,P19447,Q92830,Q13330,O95602,Q9H9Y6,P19388,P50613,P52434 Cyclin d associated events in g1 -0.19308161198240195 0.0 1.0 1.0 1.0 17 P28749,O00716,P50613,P51948 Chromosome maintenance -0.11540917112523855 0.0 1.0 1.0 1.0 75 Q9BU64,Q8N257,Q8N0S6,Q7L2Z9,Q6P0N0,O43482,Q9NZ71,Q03188,Q96JA1,Q9NSP4,P0CG13,O15084,Q96BT3 Mitotic prometaphase -0.0924546981884575 0.0 1.0 1.0 1.0 153 O75665,Q9P209,Q9UGJ1,P42677,Q66GS9,Q7L2Z9,Q8NG31,Q9NXR1,P30622,Q9NSP4,O95229,Q96BT3,Q9H081,Q96FF9,Q8NHV4,P68366,Q02224,P49674,Q9BU64,Q8N0S6,Q96RT7,Q9BYV8,Q9UPN4,Q96RT8,P31323,Q9BQE3,Q9H410,Q99871,Q03188,Q9Y5B8,O95613 Protein protein interactions at synapses -0.15522408278757208 0.0 1.0 1.0 1.0 22 Q9Y2H0,Q86YM7,Q13332,Q9NUP9 Neurexins and neuroligins -0.20299588114837455 0.0 1.0 1.0 1.0 13 Q9Y2H0,Q86YM7,Q9NUP9 Peroxisomal protein import -0.1373656085297041 0.0 1.0 1.0 1.0 36 Q92968,A8MXV4,O95822,P43155,Q9NUI1,Q6FIF0,Q13608 Processing of dna double strand break ends -0.1353700094678561 0.0 1.0 1.0 1.0 48 Q8N257,Q96RL1,Q8N2W9,Q9H9A7,Q8WXE1,O60671,Q13535,Q9BX63,Q99728,Q99638,Q92993,Q15819 Nonhomologous end joining nhej -0.17209716274132716 0.0 1.0 1.0 1.0 29 Q8N257,Q96RL1,Q8N2W9,Q6ZW49,Q92993,Q99728,Q15819,Q9NUW8,P49917 Homology directed repair -0.1179732774595336 0.0 1.0 1.0 1.0 70 Q8N257,Q96RL1,Q06609,Q8N2W9,Q9H9A7,O43502,Q8WXE1,Q96B01,O43542,O60671,Q13535,Q9BX63,Q99728,Q99638,Q92993,Q9NZ71,Q15819 Signaling by moderate kinase activity braf mutants -0.14623006588733892 0.0 1.0 1.0 1.0 22 P27448,P12931,P32121,P04049,P01111,P10398,P49407,Q6UWU4 Dna repair -0.11615028660274782 0.0 1.0 1.0 1.0 186 P50613,Q96RL1,Q06609,Q9H9A7,Q96B01,Q6ZW49,Q99728,Q9BX63,P51948,P61218,P40692,P54278,Q6P4R8,Q92560,P62877,O60671,Q9H9F9,Q9NPD8,Q99638,Q9NS91,O15287,P16455,P49917,P25490,Q8N2W9,Q99504,Q92993,Q9H981,Q01831,Q13535,Q9ULG1,Q9UBZ9,Q96EZ8,Q9NUW8,Q8NFA0,Q8N257,P45983,O43502,Q8WXE1,Q09472,O43542,Q9NZ71,Q15819,Q96NB3,Q96JA1,O94782,P23025 Base excision repair ap site formation -0.2500031545066064 0.0 1.0 1.0 1.0 8 Q8N257 Rna polymerase iii transcription termination -0.15256099968080045 0.0 1.0 1.0 1.0 12 P62875,Q9BUI4,P61218,Q9NVU0,O15160,O75575,Q9NW08,P19388,Q9H1D9,P52434 Metabolism of cofactors -0.199209921533085 0.0 1.0 1.0 1.0 11 Q9Y2Z9,Q5HYK3,Q9NZJ6,Q5T2R2,P31749,O75208 Rac2 gtpase cycle -0.16682775204560849 0.0 1.0 1.0 1.0 57 Q9UH65,Q8WUY9,Q9UHR4,Q5T5U3,Q9NYB9,Q15836,Q6ZW31,P52735,Q9H2K8 Plasma lipoprotein clearance -0.2006749587556069 0.0 1.0 1.0 1.0 20 Q6UWW8,P98155,P02654,P04114 Rhou gtpase cycle -0.16673379606283473 0.0 1.0 1.0 1.0 30 P12931,O00308,P29317,Q8WUY9,Q9Y2X7,O43639,O75886,O75044,P16333 Inlb mediated entry of listeria monocytogenes into host cell -0.2264811180672776 0.0 1.0 1.0 1.0 9 Q99963 E3 ubiquitin ligases ubiquitinate target proteins -0.18480319033762815 0.0 1.0 1.0 1.0 26 Q92968,P49459,Q149N8,Q9BTA9,Q8WVC0,Q8N2K1,Q9NS91,Q15819 Cargo recognition for clathrin mediated endocytosis -0.13627653185465688 0.0 1.0 1.0 1.0 57 Q99963,P52594,P04114,Q9NY64,O75886,Q15836,P25098,P49407,P00533,Q0JRZ9,O95208 Aurka activation by tpx2 -0.16386425389707895 0.0 1.0 1.0 1.0 54 O75665,Q9BYV8,Q9UPN4,Q9P209,Q8NHV4,Q9NXR1,P31323,Q99871,P68366,Q66GS9,P49674 Transcriptional regulation by ventx -0.19019918187965346 0.0 1.0 1.0 1.0 22 Q9UM13,P19838,Q9UPQ9,Q8NDV7,Q9UL18 Met activates ras signaling -0.24482168546965957 0.0 1.0 1.0 1.0 6 P29353,P01111 Signaling by ptk6 -0.1892163415452033 0.0 1.0 1.0 1.0 22 P04150,Q9NRY4,Q96P48,P31749,P01111,P20936,P00533,P49023 Rna polymerase iii transcription initiation from type 1 promoter -0.17871956717763973 0.0 1.0 1.0 1.0 18 Q9Y5Q8,Q969F1,Q9UKN8,Q9BUI4,Q12789,P52434,P19388,Q9NVU0,O15160,Q9Y5Q9,O75575,Q92994,Q9NW08,O14802,P61218,Q8WUA4,Q9H1D9,P62875 Platelet activation signaling and aggregation -0.13167114433470903 0.0 1.0 1.0 1.0 93 P62328,P04049,P06241,Q9HAV0,P68366,P08962,Q05513,P52735,Q9BX10 Insulin receptor signalling cascade -0.22709426308700142 0.0 1.0 1.0 1.0 11 Q13322,P01111,P29353 Rna polymerase iii transcription -0.20022469161432133 0.0 1.0 1.0 1.0 20 Q969F1,P14859,O75575,Q92994,Q9H1D9 Hdr through homologous recombination hrr -0.16938963098666074 0.0 1.0 1.0 1.0 44 Q06609,Q9H9A7,O43502,Q8WXE1,Q96B01,Q15054,O43542,O60671,Q13535,Q9BX63,Q13315,Q99728,Q99638,Q92993,Q13472,Q9NZ71,Q14191 Raf activation -0.1910035039566241 0.0 1.0 1.0 1.0 21 P27448,P12931,P04049,P36873,Q13557,P01111,Q13362,P10398,Q6UWU4 Rho gtpases activate formins -0.1268099520788344 0.0 1.0 1.0 1.0 101 Q9BU64,Q8N0S6,Q9H081,Q9NXR1,Q9BQE3,Q9H410,Q8N9R8,P68366,Q03188,P08134,O75044,O95229,Q96BT3 Signaling by fgfr1 in disease -0.19243495482551415 0.0 1.0 1.0 1.0 16 O95684,O15164,Q16630,O94905,Q32MZ4,P11274,P51692,Q9UBW7,Q92614,P19174,P01111,P40763,P42224,O95429,P39880 Epha mediated growth cone collapse -0.19134790642885946 0.0 1.0 1.0 1.0 14 P12931,P29317,Q8N5V2,P06241 Signal amplification -0.23306421791784615 0.0 1.0 1.0 1.0 14 P12931,Q13685,P50148,Q9UBI6,P63096,P62873,P62879,Q9HAV0,P04899,Q16539,P29992,P63218,Q14344 Regulation of glycolysis by fructose 2 6 bisphosphate metabolism -0.25173841575090894 0.0 1.0 1.0 1.0 6 P22694 Striated muscle contraction -0.18537485595638997 0.0 1.0 1.0 1.0 9 P35609,P11532,Q8WZ42 Post chaperonin tubulin folding pathway -0.20927269669935986 0.0 1.0 1.0 1.0 14 P68366,Q9BQE3 Ctla4 inhibitory signaling -0.210410412902181 0.0 1.0 1.0 1.0 13 P12931,P06241,P31749,Q13362,Q9Y243 Cd28 co stimulation -0.1779964572079052 0.0 1.0 1.0 1.0 16 P12931,P06241,P31749,Q6R327,Q9Y243,Q13153 Deactivation of the beta catenin transactivating complex -0.17360735532720215 0.0 1.0 1.0 1.0 16 O00255,P25054,P63104,P98170,Q15291,P35222,O14980,Q9Y297,P31749,Q13547,Q9HCK8,Q9UBL3,Q04726,Q04727,Q13363,P31751 Diseases of programmed cell death -0.16967079865799461 0.0 1.0 1.0 1.0 39 Q8N257,P05412,O43524,Q9UBC3,Q13158 Nephrin family interactions -0.19101302310860163 0.0 1.0 1.0 1.0 14 O43639,Q96J84,P06241,O00401,P35609,P16333 Hdacs deacetylate histones -0.1801794586978482 0.0 1.0 1.0 1.0 24 Q8N257,Q4LE39,Q12873,O15379,Q9BZK7,Q9H7L9,Q9BTC8,O75446,P29374 Regulation of innate immune responses to cytosolic dna -0.21080359416224825 0.0 1.0 1.0 1.0 6 Q9UHD2,Q9BRZ2,Q13049 Insulin processing -0.21456140938869891 0.0 1.0 1.0 1.0 18 O60282,P16870,Q86YB8,Q6NXT4,P51159 The phototransduction cascade -0.2253981011660902 0.0 1.0 1.0 1.0 8 O60551 Selective autophagy -0.13399433797584911 0.0 1.0 1.0 1.0 52 O95613,Q13099,Q9Y478,Q14596,Q9BQE3,Q96B49,Q9H1Y0,P68366,Q99541,Q70CQ3,Q8IVP5,Q9UBN7 Signaling by receptor tyrosine kinases -0.12936286456664078 0.0 1.0 1.0 1.0 187 Q99963,P46937,O43251,Q92558,P20936,Q05513,P52735,P29353,Q13332,Q6R327,O75886,Q9NZ52,P16220,Q9BUB5,P51692,P06241,Q13322,O43639,P01111,P17301,Q9NYB9,P00533,P01106,Q05193,Q13164,Q16644,Q9Y316,Q09472,Q9Y243,P49768,P18846,O15379,Q96JA1,P22694,P17706 Constitutive signaling by aberrant pi3k in cancer -0.2134820927473606 0.0 1.0 1.0 1.0 10 P12931,O43815,O00459,P06241,Q9NWH9,P63000,P00533,Q06124,P84095 Activation of rac1 -0.24018725243067868 0.0 1.0 1.0 1.0 9 O96013,Q16512,O94813,O43639,P63000,Q13153,Q13177,P16333,Q9Y6N7 Role of abl in robo slit signaling -0.21691445779699822 0.0 1.0 1.0 1.0 6 P40123,Q9Y6N7 Signaling by fgfr4 in disease -0.236834881831755 0.0 1.0 1.0 1.0 3 P01111 Signaling by fgfr4 -0.2204843134271467 0.0 1.0 1.0 1.0 11 Q9BUB5,P12931,P29353,P01111 Signaling by fgfr3 -0.2204843134271467 0.0 1.0 1.0 1.0 11 Q9BUB5,P12931,P29353,P01111 Signaling by fgfr1 -0.2204843134271467 0.0 1.0 1.0 1.0 11 Q9BUB5,P12931,P29353,P01111 Traf6 mediated nf kb activation -0.22667616294648174 0.0 1.0 1.0 1.0 12 P19838,Q9Y6K9,Q12933,O14920,Q00653,Q04206,Q9C037 Negative regulators of ddx58 ifih1 signaling -0.20180186719875062 0.0 1.0 1.0 1.0 13 Q9UHD2,Q9UII4,Q86VP1,Q96G74,Q9H1Y0,Q9C037 Vesicle mediated transport -0.09488722256130953 0.0 1.0 1.0 1.0 413 Q8WXG6,P08174,Q96CN9,Q99963,P04114,Q9BTE1,Q0JRZ9,Q9Y5R8,Q9Y3Q3,Q8IWF6,Q147X3,O00189,O95208,Q8NI22,P14672,Q86VX9,O95755,P20336,O43426,Q9NY64,Q9UL33,Q9NZ52,P17302,Q86TI0,O00399,P31947,Q9NRW1,Q9HA65,Q9BY43,Q6ZUT9,P36383,Q9Y6B7,P68366,Q2PPJ7,Q15836,Q9UPM8,Q5T0N5,P51159,O94955,P02794,A5PLN9,Q96QF0,Q9UBR2,P25098,Q9BQE3,Q16890,Q86SZ2,P49418,P39880,Q8WVT3,Q96CV9 Rho gtpases activate iqgaps -0.16737190963548562 0.0 1.0 1.0 1.0 17 P68366,Q9BQE3 Pyroptosis -0.17386815139916018 0.0 1.0 1.0 1.0 13 Q9BY43 Metabolism of lipids -0.1357392851223085 0.0 1.0 1.0 1.0 320 P36873,Q96CM8,P33897,Q9UHV7,O15120,O75881,Q8N5B7,P49585,Q99519,Q5K4L6,Q5SGD2,P25208,Q96AD5,P10109,Q9NZD2,Q32NB8,P43155,Q9HA82,Q13613,Q99541,Q96RS0,Q9C0I1,O14561,O95248,Q6ZMG9,P98164,Q99447,Q12923,P11474,Q9H944,Q96PE7,Q643R3,O60427,Q8WTS1,Q8IWA5,P08047,P41247,Q92793,Q8N4T8,P48426,Q12770,Q9NYA4,Q9C0D9,Q9NUI1,O15379,P22694,Q15528,Q8WWI5,Q8TCG2,O15357,Q9Y3C7,P68400,P78356,P07108,Q86TX2,Q86SK9,Q9Y2I7,O75182,O94806,Q08AM6,O95749,Q6JQN1,P49137,Q96K12,Q9HAU0,O95822,Q9NZC3,Q9BZK7,P24863,Q9HBU6,P13196,Q9BUE0,Q9BT40,Q9Y6K0,Q8TCT0,Q09472,Q9BXW6,Q7L5N7,Q9BR61,Q86V21,O75192,P49336,O95379,O95342,Q8NEB9,Q9NRZ5,O43426,Q13496,Q8IVH4,P56937,Q6P2C8,Q9H1P3,Q8N2W9,Q16698,P28702,O94830,Q06520,A8MXV4,Q9BV79 Negative epigenetic regulation of rrna expression -0.16565463788243978 0.0 1.0 1.0 1.0 40 Q8N257,Q4LE39,Q15361,Q9H7L9,P51948,Q9UBC3,Q15573,P50613 Synthesis of gdp mannose -0.29667507437599394 0.0 1.0 1.0 1.0 4 O15305 Asparagine n linked glycosylation -0.1116788031560556 0.0 1.0 1.0 1.0 188 A2VDF0,P08174,Q9BVK2,Q5SRI9,O15305,Q8WU17,Q9BTE1,Q9Y5R8,Q9Y3Q3,Q9Y672,Q8TBE9,Q8NI22,O15084,O14772,O60512,Q11206,Q9UL33,Q9UKM7,Q9NP73,Q09328,O00399,Q86TM6,Q9Y274,O94808,Q96E22,Q9BYC5,P68366,Q9NYU1,Q96F25,Q10469,Q9UPQ8,Q9H6U8,Q9UPN7,Q9UBR2,Q9BQE3,Q86SZ2 Signal transduction by l1 -0.18961064678012202 0.0 1.0 1.0 1.0 16 Q16512,O14786,P68400,P28482,P27361,P63000,Q13153,P00533,P67870,P06756,P13591,P36507,P52735,P19784,Q02750 Lysosome vesicle biogenesis -0.1576998172883326 0.0 1.0 1.0 1.0 24 Q9UBR2,Q9Y6B7,P49407,O00115,O00189,Q9UPM8 Inactivation of cdc42 and rac1 -0.2780710413382917 0.0 1.0 1.0 1.0 5 O75044,Q9Y6N7 Ion channel transport -0.11721402090940879 0.0 1.0 1.0 1.0 46 Q9NTM9,Q9Y3S1,O75348,P04049,Q96BR1,Q9NQ11,Q86WC4,Q9BYP7,Q5EBL8,Q04656,Q8TEL6,Q99576,P51797