Is SM-102 a safe ingredient in the Moderna vaccine, despite these safety warnings?

I recently saw a post online which called into question the safety of the Moderna vaccine through an interesting argument. One of the ingredients in the Moderna COVID-19 vaccine is the ionizable amino lipid SM-102. [Source] Information about this chemical can be found on this website . As expected, the description of this chemical is the following: SM-102 is an ionizable amino lipid that has been used in combination with other lipids in the formation of lipid nanoparticles.1 Administration of luciferase mRNA in SM-102-containing lipid nanoparticles induces hepatic luciferase expression in mice. Formulations containing SM-102 have been used in the development of lipid nanoparticles for delivery of mRNA-based vaccines. However, as a standalone chemical it seems to have many safety warnings and hazards. This information is available on the accompanying safety data sheet for SM-102 . Here are some of the listed hazards: WARNING This product is not for human or veterinary use. H310 Fatal in contact with skin. H351 Suspected of causing cancer H372 Causes damage to the central nervous system, the kidneys, the liver and the respiratory system through prolonged or repeated exposure. Now, my presumption is that these hazards are supposed to be overly cautionary, and also only apply to the direct handling of the raw chemical. But many people do not see it this way, and thus are reasonably skeptical about the safety of the Moderna vaccine. So, I have a couple questions: Questions. Are all these hazards relevant to the chemical's pharmacological use as part of an mRNA vaccine? Why? How are these hazards determined in the first place? Are there examples of other chemicals with similar hazards/warnings, which are ingredients in common medical drugs? Opposite to the previous question, are there chemicals with little to no hazards/warnings, which nevertheless form key components to actually dangerous drugs?

The MSDS linked to is for a product sold as a solution of 10% SM-102 in 90% chloroform. It's listed as "SM-102" because that's the interesting/useful thing that the company is selling. It's common for chemicals to be sold packaged with solvents to make a solution. Sometimes that solvent is just water, but if the product is not water-soluble in sufficient concentrations then other solvents may be necessary. Alcohol solutions are quite common, but for more hydrophobic chemicals it may be necessary to use more "exotic" solvents. Because chloroform is quite a dangerous chemical for people to be exposed to...

In the blister shown, the likelihood of rupture is decreased because of the thickness of the epidermis on the palm of the hand, so you can leave it alone until the underlying area re-epithelializes. You'll know this is happening because of the decreased pain and the slow reabsorption of the fluid. Eventually you will just peal it off what's left of the blister, finding clean new skin underneath. But this is a great starting point for an answer about the treatment of blisters in general: is it better to leave them alone, drain the fluid, or de-roof them (take the...

Your question contains a lot of misconceptions. A cure is definitely possible A cure could be found, proved, and proved safe, more quickly than a vaccine People and firms that could be working on cures are choosing to work on vaccines None of these are correct. Most virus-caused diseases have no cure: colds, Zika, Dengue, and so on. A tiny handful have treatments that can ease the course of the disease: you've heard of Tamiflu and so on. And some can be actually cured with medication. So the first assumption, that a cure exists to be found, is not a...

To add to @BryanKrause's answer re: rare events happen all the time, the children are not out of the woods yet. The mean incubation time for a primary VZV infection (the clinical syndrome known as chicken pox) is 14 days, but often lasts up to 21 days (see Murray Medical Microbiology, Ch. 53). The father is infectious while shedding virus, usually via the lungs. This correlates with the period of time a patient is febrile. I wouldn't say the father didn't infect his children until he has been afebrile for 21 days.


Is there any proof that acupuncture is an effective pain remedy?

I have heard of acupuncture being used for pain management. Are there clear scientific proofs that indicate it is more effective than a placebo treatment for pain? If so what types of pain has it been shown to effective for?

pain treatment-options effectiveness placebo acupuncture

People could develop antibodies from natural exposure to the virus. The vaccine is trying to cause antibodies to exist in more people (and/or more strongly) than would express them naturally, therefore a good comparison group is a sample taken randomly in the same way as those getting the vaccine: a placebo group. At the same time, these trials tend to assess safety outcomes; again, to assess safety you want to know that effects are no worse than those in some comparison population. Comparing to placebo is typically a gold standard for this comparison. You're right that a placebo wouldn't be...

There is evidence that neonatal circumcision saying that the benefits of circumcision outweigh the risks. According to a study done on neonatal circumcision [1] , the lifetime benefits of being circumcised outweighed the risks 100 to 1. Some of the risks people may associate with circumcision are very unlikely. Excessive bleeding only happens 0.1% of the time, infections 0.02% of the time, and loss of penis 0.0001% of the time. The percentage of death is only 0.00001%. Overall, it shows that males who have been circumcised require half as much medical attention as males who have not been circumcised. Also,...

tl;dr Current research seems to indicate that the brain is responding to anticipation or visual stimulus of needles being inserted, not that any of the theories supporting acupuncture are correct. Steven Novella reviewed the following article : Chae Y, Lee IS, Jung WM, Park K, Park HJ, Wallraven C. Psychophysical and neurophysiological responses to acupuncture stimulation to incorporated rubber hand. Neurosci Lett. 2015 Feb 11;591C:48-52. doi: 10.1016/j.neulet.2015.02.025. I'm going to quote from Novella's review because it's easier for a lay person to read/understand, and I don't have full access to the paper. As background, he states: There have been in...

Products high in calcium and magnesium should not be taken at the same time as antibiotics of the tetracycline (tetracycline, doxicycline, etc.) class, and milk should also be avoided with the quinolone class. They have the ability to bind the antibiotic in the gut, decreasing absorption. There is no reason to avoid dairy products while taking other antibiotics (such as the penicillin class, the one you're taking. The clavulanic acid is to increase it's strength against certain bacteria.) If the antibiotic package insert (or the pharmacists's instruction sheet) states it should be taken on an empty stomach, take it with...


I've googled through internet, and all I found was "what expiration dates mean". I found nothing about the underlying mechanism of expiration. As drugs are chemicals, why do they expire? Are there chemical reactions that produce other chemicals?

Drug molecules, even when stored safely inside a tablet\capsule, inside a closed container, upon a high shelf (hopefully), are still exposed to the environment, and are thus exposed to all of the chemical processes and reactions that go about all around us (to name just a few - oxidation, hydrolysis, isomerization, polymerization, and more). Depending on the type of drug molecule and its functional groups, the molecule may undergo all kinds of chemical processes that may change its structure and\or properties. Therefore, drugs (and foodstuffs, as mentioned in the comment above) degrade and decompose over time, and are thus given...

In general, the benefit of flu shots is to the general population. Taking the cited value of 40%-60% from the CDC, we can say that it might be a coin toss for you personally to be protected from influenza by the shot. However, if many thousands of people take the flu shot, even if it only works on 40% of them, it helps protect the remaining population from the spread of the virus (AKA herd immunity). This is especially important to those within the population who cannot access the shot or cannot receive it due to a preexisting medical condition....

Your question contains a lot of misconceptions. A cure is definitely possible A cure could be found, proved, and proved safe, more quickly than a vaccine People and firms that could be working on cures are choosing to work on vaccines None of these are correct. Most virus-caused diseases have no cure: colds, Zika, Dengue, and so on. A tiny handful have treatments that can ease the course of the disease: you've heard of Tamiflu and so on. And some can be actually cured with medication. So the first assumption, that a cure exists to be found, is not a...


As of time of writing it's quite common to see headlines about so-and-so who have tested positive for Covid-19, e.g. Canadian PM Justin Trudeau's wife, Sophie, tests positive for coronavirus, officials say However, these articles don't usually say how reliable the testing is. I couldn't find any recent information on it via Google, either (there are some results, e.g. this , but they are old). How accurate are the tests? What are the odds that Sophie Trudeau's results are a false positive, or that Justin Trudeau's negative result is a false negative?

Short answer: Sophie Trudeau's positive test may still mean 3 : 1 odds of not having contracted Covid-19, but the odds could also be far more towards having Covid-19. Justin Trudeau's negative test almost certainly means he was negative when tested. Of course, should Sophie be positive, that may have changed by now. Update: I found a web page of the FDA listing tests that have this Emergency Use Approval . Each of them has manufacturer instuctions that list their test results towards the end. Some of the submitted test results use ≈100 negative samples in the clinical evaluation. But...

The only approved inhaled vaccine is the flu vaccine delivered intra-nasally. It uses a live attenuated virus. There are a whole list of people who should not receive it because it's a live virus, and it works better for children, but only is 40% effective for adults. The main issue is The intranasal LAIV, recommended for children above the age of 2 years, induces a broader immune response wherein protection is not antibody mediated and probably involves undefined multiple correlates of protection. and that's with a live virus. How well would a dead inhaled virus work? Well, we have some...

People could develop antibodies from natural exposure to the virus. The vaccine is trying to cause antibodies to exist in more people (and/or more strongly) than would express them naturally, therefore a good comparison group is a sample taken randomly in the same way as those getting the vaccine: a placebo group. At the same time, these trials tend to assess safety outcomes; again, to assess safety you want to know that effects are no worse than those in some comparison population. Comparing to placebo is typically a gold standard for this comparison. You're right that a placebo wouldn't be...

The short version is that in 2016 the polio vaccine changed. A more thorough explanation requires some background on the immunology of polio and its vaccines, which is not straightforward. Polio virus is usually harmless, it reproduces in the gut and spreads through a fecal-oral route. In ~99% of infections it only causes mild diarrhea. In the remaining 1% of cases, however, it gets into the bloodstream and from there enters nerves, causing paralysis and/or respiratory failure. There are two types of vaccine: inactivated polio vaccine (IPV) and oral polio vaccine (OPV). IPV is a shot of killed virus particles...


Do you bleed to death after your penis is cut off?

I wonder If a person without knowledge and tools cuts off somebody's penis and then doesn't call an ambulance immediately, is there a chance a person may not bleed to death within a short time? I would also like to know if you can still urinate, while the cutting is done without some tool you put into urethra? I haven't found much related to this topic.

Assuming the person is not taking anticoagulants, it's actually quite difficult to bleed to death from dismemberment of small members (hands, feet, penis, ears, nose, etc). Even large members such as arms and legs are often survivable because the body is very good at protecting itself from blood loss. For example, transected arteries will spasm and clamp off blood flow, and loss of blood will cause the body to divert blood flow away from the extremities and to the vital organs, thereby slowing the bleeding and allowing it to clot. In fact, the whole shock process can be viewed as...

Great question! I think it's answerable as an overview, but please know this is only the tip of the iceberg.* Summary : Yes, we have deficits of certain blood products in certain locations at certain times that affect patient care. However, a small percentage of blood product does expire unused (because it wasn't the right product [see background] in the right place at the right time). A little background Donated blood is not usually transfused into a patient as whole blood. Instead, it's broken down into several components which are transfused in different clinical scenarios. The issues of storage and...

Drug molecules, even when stored safely inside a tablet\capsule, inside a closed container, upon a high shelf (hopefully), are still exposed to the environment, and are thus exposed to all of the chemical processes and reactions that go about all around us (to name just a few - oxidation, hydrolysis, isomerization, polymerization, and more). Depending on the type of drug molecule and its functional groups, the molecule may undergo all kinds of chemical processes that may change its structure and\or properties. Therefore, drugs (and foodstuffs, as mentioned in the comment above) degrade and decompose over time, and are thus given...

I'm guessing the "iron" test was actually a hemoglobin test (though I'm certainly no expert in blood donation screens...). I suspect your nurse is reporting a folk tale rather than any true difference. Unfortunately, medical professionals are not always an excellent source of scientific knowledge. I looked for papers that have actually compared measurements in the two hands. Here's one: Patel, A. J., Wesley, R., Leitman, S. F., & Bryant, B. J. (2013). Capillary versus venous haemoglobin determination in the assessment of healthy blood donors. Vox sanguinis, 104(4), 317–323. https://doi.org/10.1111/vox.12006 Capillary fingerstick samples were assayed by HemoCue in 150 donors....


Why will there be vaccines first before a cure for COVID-19?

I found this link on the internet: 70 vaccines are getting ready for coronavirus: 3 very promising Why is it that there will be vaccines before a cure? Shouldn't it be the other way around? What is the reason for the vaccine first then the cure?

Your question contains a lot of misconceptions. A cure is definitely possible A cure could be found, proved, and proved safe, more quickly than a vaccine People and firms that could be working on cures are choosing to work on vaccines None of these are correct. Most virus-caused diseases have no cure: colds, Zika, Dengue, and so on. A tiny handful have treatments that can ease the course of the disease: you've heard of Tamiflu and so on. And some can be actually cured with medication. So the first assumption, that a cure exists to be found, is not a...

Overall, there has been inconsistent data on the effects of using zinc lozenges to treat the common cold. Most studies have also been done on children, which may lead to more uncertainty about its effects on adults, but some of the studies I will mention have been tested on adults. One study showed the effects of using zinc to prevent the common cold in schoolchildren. They found that between the two groups they studied (one took zinc sulfate tablets, the other placebos) that the zinc-supplemented group had less of a chance of getting the cold. They concluded that zinc supplements...

Assuming the person is not taking anticoagulants, it's actually quite difficult to bleed to death from dismemberment of small members (hands, feet, penis, ears, nose, etc). Even large members such as arms and legs are often survivable because the body is very good at protecting itself from blood loss. For example, transected arteries will spasm and clamp off blood flow, and loss of blood will cause the body to divert blood flow away from the extremities and to the vital organs, thereby slowing the bleeding and allowing it to clot. In fact, the whole shock process can be viewed as...

One of the primary purposes of corticosteroids is to suppress immune activity and inflammation: that's exactly why they are used in asthma. Of course the immune system has an actual job besides causing nuisance inflammation: fighting infection. For some infections, the harm to the infected person caused by the immune reaction itself is worse than that of the pathogen itself, so steroids can help prevent damage or ease symptoms while the immune system continues to mount a response, without being hyper active. For others, immune suppression may be detrimental. Corticosteroids mediate the immune response by suppressing a variety of cytokines...


Advantages of transition from non-vegetarian to vegetarian

Influenced by PETA, a lot of people have already changed to vegan status. I would like to know how well the transition may work? It can be either in a physical or mental way. Some have changed for religious views, some for humanitarian reasons. But I would like to know the health beneficial aspects.

In the blister shown, the likelihood of rupture is decreased because of the thickness of the epidermis on the palm of the hand, so you can leave it alone until the underlying area re-epithelializes. You'll know this is happening because of the decreased pain and the slow reabsorption of the fluid. Eventually you will just peal it off what's left of the blister, finding clean new skin underneath. But this is a great starting point for an answer about the treatment of blisters in general: is it better to leave them alone, drain the fluid, or de-roof them (take the...

This is a question that cannot be answered by a simple yes or no. As a vegetarian for health purposes (who was a vegan for 1 year) I say that the human isn't supposed to be vegetarian, but rather an opportunistic omnivore. The fact that we can eat meat doesn't mean we have to. Most of people that went from non-vegetarian to vegetarian (no meat, no fish) felt better the following weeks, however the reasons could be numerous and ambiguous: Maybe they were eating too much meat until they stopped ? Maybe the meat they were buying was bad quality...

Let's get a few things out of the way... Sex is normal ( 1 ). Sexual desire and arousal are normal ( 2 ). Asexuality is normal ( 3 ). Masturbation is normal ( 4 ),( 5 ). There is no problem whatsoever with these three things, although everyone blushes when they talk about them. Is Masturbation healthy? Downsides : Masturbation is not risk free. It is about as dangerous as chewing or walking ( 6 ). Some side effects are irritated skin and ruptured penis, but only if you really, really, really overdo it (Once or twice a day...


Why is thalidomide a current drug on the market?

Given the thalidomide birth defect disaster of the 1960s, why was it later approved by the U.S. FDA for treatment of leprosy (1996) and of multiple myeloma (2006)? Presumably, the teratogenic issues and problems with permanent nerve damage didn't go away, as the liver can convert the "good" enantiomer to the "bad." Thalidomide affects even non-pregnant women, so why approve a drug with known severe complications?

Because leprosy and multiple myeloma are conditions for which other treatment options are limited. All treatments have side effects, some more debilitating than others. The trick with pharmacology is to balance the benefit of treatment with the hazards of the side effects. Take cancer chemotherapy. The drugs we use for cancer chemotherapy are horrible poisons. We literally use derivatives of chemical weapons to treat cancer. Why do we deliberately poison cancer patients with what amounts to a weapon of mass destruction? Because if we don't, the cancer will kill them. In pharmacology there's a concept of a therapeutic window ....

It is not possible. The regulation of human body temperature (thermoregulation) is very subtle. Wikipedia article about thermoregulation contains a very nice graph about that mechanism. The labels are not described in the text in detail and the reference in the caption does not include this picture. Picture is a work by one JW Dietrich and I also searched PubMed for this guy, but he has no works on this topic. Another more pragmatic picture is here. Fever or increased body temperature is almost solely caused by to the production prostaglandin E2 (PGE2) . PGE2 acts on the hypothalamus or...


How are ratios for one person CPR arrived at?

I have not had a CPR (Cardiopulmonary resuscitation) class in 10 or more years, but I used to take them all the time ( like yearly ). For one person CPR the ratio of compression to breaths was always changing. In the US there were two major providers of approved CPR training, It was not unusual for both to have different ratios as "the correct value" at the same time, and the following year, one or both would be different. How are the ratios determined? What impact if any do minor changes in the ratio have?

Note: The following is excerpted from an article written in 2005. For lay (Non trained) people, there are more updated recommendations. The following is an example of the process, not the current recommendations. To be effective, CPR must restore adequate coronary and cerebral blood flow. Interruptions in chest compressions lower coronary perfusion pressure and decrease rates of survival from cardiac arrest. In the first minutes of VF SCA, ventilation does not appear to be as important as chest compressions, but it does appear to contribute to survival from prolonged and asphyxial arrest. Certainly the ventilation rate needed to maintain a...

People could develop antibodies from natural exposure to the virus. The vaccine is trying to cause antibodies to exist in more people (and/or more strongly) than would express them naturally, therefore a good comparison group is a sample taken randomly in the same way as those getting the vaccine: a placebo group. At the same time, these trials tend to assess safety outcomes; again, to assess safety you want to know that effects are no worse than those in some comparison population. Comparing to placebo is typically a gold standard for this comparison. You're right that a placebo wouldn't be...

I believe that those lines are craze lines. "Craze lines are merely cracks in the enamel that do not extend into the dentin." They occur because of stress in your teeth, ie: grinding your teeth, biting your nails, and even routine use of your teeth. What you've said also matches up with craze lines in that you don't experience any pain. Those craze lines aren't nearly as bad as some other teeth. Craze lines rarely lead to tooth breakdown, so you almost definitely won't have to get them replaced. There are some studies that say that craze lines may be...

The seasonal coronaviruses attach exclusively to cells with a ciliated epithelium. Coronaviruses invade the respiratory tract via the nose. After an incubation period of about 3 days, they cause the symptoms of a common cold, including nasal obstruction, sneezing, runny nose, and occasionally cough (Figs. 60-1 and 60-2). The disease resolves in a few days, during which virus is shed in nasal secretions. There is some evidence that the respiratory coronaviruses can cause disease of the lower airways but it is unlikely that this is due to direct invasion. Other manifestations of disease such as multiple sclerosis have been attributed...


We recently got some new kittens and my step son is allergic to them. He mostly suffers from a runny nose, but also had itchy eye last night after he Left a robe in the kitten room all day Put it on after getting home from school Kept scratching his eye after playing with the kittens etc. Anyway, so he's trying an antihistamine to see if this will combat the allergies. From sites like WebMD I've read that the cat allergy is an overreaction of his immune system. Is the antihistamine doing something regarding his immune's system reaction or is it doing something about the symptoms? How does it work? Will his immune system learn how to behave whilst taking antihistamines? Would the process of learning be better or worse for taking them?

A very brief review of an allergic response is in order so that the answer makes sense. Think of a linked chain of events here. An "allergen" is something a person is allergic to, e.g., cat dander or pollen. When someone is exposed to an allergen, they either become allergic or not. In a susceptible individual, something in the allergen (called an antigen, usually a protein of some kind) causes the person's immune system to produce an antibody (or Immunoglubin, in this case Immunoglobin E, or IgE) to the antigen, which then circulates throughout the entire system. The individual is...

The definition of mortality rate that you've given does not match any practical definition I'm familiar with.* When people talk about the mortality rate of a disease, what they usually mean is the case fatality rate or the death-to-case ratio , which is simply defined as N d / N i , where N d is the number of deaths attributed to the disease over a given time period and N i is the total number of new cases of the disease observed during the same time period. By this definition, the current case fatality rate of 2019-nCov according to...

Most dentists - for most procedures - aim for a painless experience. If there is reason to keep some pain sensation intact, the dentist will inform you, and ask at appropriate intervals if you can feel pain. The efficacy of lidocaine and other local anesthetics depends on how closely your nerve distribution comes to the norm (they will inject the environs of the "normal" anatomical position of the nerve), how much anesthetic is injected, whether there are local factors which alter the local tissue pH (e.g. presence of an abscess or infection), how quickly it is removed from the site,...


Are there any side effects to cracking knuckles?

I constantly crack (or pop) my knuckles. Are there any negative (or positive) side effects to it? I like to crack my knuckles, but I want to stop if it can have negative effects. What have scientific studies said about this subject?

A common medical myth is that cracking your knuckles causes arthritis, but is has been shown that cracking your knuckles, and popping your joints in general, will not raise your risk for developing arthritis. 1 It has also been shown to not cause degenerative joint disease in your hand joints in old age. 2 However, cracking your knuckles does have some risks. One study from 1990, 3 showed that, while cracking your knuckles does not increase your risk of arthritis, it does impair your hand function. It was shown to lower grip strength and cause hand inflammation in habitual knuckle...

I'm guessing the "iron" test was actually a hemoglobin test (though I'm certainly no expert in blood donation screens...). I suspect your nurse is reporting a folk tale rather than any true difference. Unfortunately, medical professionals are not always an excellent source of scientific knowledge. I looked for papers that have actually compared measurements in the two hands. Here's one: Patel, A. J., Wesley, R., Leitman, S. F., & Bryant, B. J. (2013). Capillary versus venous haemoglobin determination in the assessment of healthy blood donors. Vox sanguinis, 104(4), 317–323. https://doi.org/10.1111/vox.12006 Capillary fingerstick samples were assayed by HemoCue in 150 donors....

The MSDS linked to is for a product sold as a solution of 10% SM-102 in 90% chloroform. It's listed as "SM-102" because that's the interesting/useful thing that the company is selling. It's common for chemicals to be sold packaged with solvents to make a solution. Sometimes that solvent is just water, but if the product is not water-soluble in sufficient concentrations then other solvents may be necessary. Alcohol solutions are quite common, but for more hydrophobic chemicals it may be necessary to use more "exotic" solvents. Because chloroform is quite a dangerous chemical for people to be exposed to...

Assuming the person is not taking anticoagulants, it's actually quite difficult to bleed to death from dismemberment of small members (hands, feet, penis, ears, nose, etc). Even large members such as arms and legs are often survivable because the body is very good at protecting itself from blood loss. For example, transected arteries will spasm and clamp off blood flow, and loss of blood will cause the body to divert blood flow away from the extremities and to the vital organs, thereby slowing the bleeding and allowing it to clot. In fact, the whole shock process can be viewed as...


How many times a week is masturbating good for health?

I'm 18 years old. Every weekend I watch a pornographic film and when it finishes, I do a hand job. In addition, on weekdays, I masturbate. My question is: Is it good for your health or not?

Race and ethnicity are risk factors in many diseases. Examples include, but are not limited to, cystic fibrosis and spinal muscular atrophy. There is also an epidemiological purpose of collecting this information. It is important to know if some disease is affecting some races or some ethnicities disproportionately. This is how it was found out that race or ethnicity is a risk factor in certain diseases in the first place. RFERENCES: Sheets L, Johnson J, Todd T, Perkins T, Gu C, Rau M. Unsupported labeling of race as a risk factor for certain diseases in a widely used medical textbook....

I believe that those lines are craze lines. "Craze lines are merely cracks in the enamel that do not extend into the dentin." They occur because of stress in your teeth, ie: grinding your teeth, biting your nails, and even routine use of your teeth. What you've said also matches up with craze lines in that you don't experience any pain. Those craze lines aren't nearly as bad as some other teeth. Craze lines rarely lead to tooth breakdown, so you almost definitely won't have to get them replaced. There are some studies that say that craze lines may be...

In the blister shown, the likelihood of rupture is decreased because of the thickness of the epidermis on the palm of the hand, so you can leave it alone until the underlying area re-epithelializes. You'll know this is happening because of the decreased pain and the slow reabsorption of the fluid. Eventually you will just peal it off what's left of the blister, finding clean new skin underneath. But this is a great starting point for an answer about the treatment of blisters in general: is it better to leave them alone, drain the fluid, or de-roof them (take the...


Why do corticosteroids harm COVID-19 patients?

This Science Daily article states that steroids could do more harm than good in treating coronavirus (COVID-19), referring to this The Lancet article . Understanding the evidence for harm or benefit from corticosteroids in 2019-nCoV is of immediate clinical importance. It's unclear to me how exactly the use of corticosteroids (which is a common treatments for Asthma patients) can do harm other than the vague explanation of "steroids also impair the immune system's ability to fight viruses". How exactly does the use of steroids harm the body in case of fighting a virus such as SARS-CoV-2 (2019-nCoV) that causes COVID-19?

covid-19 asthma virus steroids corticosteroids

One of the primary purposes of corticosteroids is to suppress immune activity and inflammation: that's exactly why they are used in asthma. Of course the immune system has an actual job besides causing nuisance inflammation: fighting infection. For some infections, the harm to the infected person caused by the immune reaction itself is worse than that of the pathogen itself, so steroids can help prevent damage or ease symptoms while the immune system continues to mount a response, without being hyper active. For others, immune suppression may be detrimental. Corticosteroids mediate the immune response by suppressing a variety of cytokines...

Race and ethnicity are risk factors in many diseases. Examples include, but are not limited to, cystic fibrosis and spinal muscular atrophy. There is also an epidemiological purpose of collecting this information. It is important to know if some disease is affecting some races or some ethnicities disproportionately. This is how it was found out that race or ethnicity is a risk factor in certain diseases in the first place. RFERENCES: Sheets L, Johnson J, Todd T, Perkins T, Gu C, Rau M. Unsupported labeling of race as a risk factor for certain diseases in a widely used medical textbook....

It is likely you are not hearing the ultrasound itself (typical frequencies are upwards of 1 MHz , far beyond what the human hearing system is capable of detecting). You are probably hearing coil whine from the electronics -- switched-mode power supplies in particular tend to operate towards the upper end of the hearing range, and the intensity of this sound changes as the power consumption does (eg. when the imaging system goes from "idle" to "active").


Why does whooping cough last so long and can the duration of cough be reduced?

Whooping cough is a chronic cough resulting from an infection with the bacteria Bordetella Pertussis. The cough resulting from the infection may last several weeks, and as such whooping cough is sometimes called the 100 day cough. Why is it that the Bordetealla Pertussis infection produces a cough that lasts so long compared to other infections, and is there anything that can be done to reduce the cough's duration?

Great question! I think it's answerable as an overview, but please know this is only the tip of the iceberg.* Summary : Yes, we have deficits of certain blood products in certain locations at certain times that affect patient care. However, a small percentage of blood product does expire unused (because it wasn't the right product [see background] in the right place at the right time). A little background Donated blood is not usually transfused into a patient as whole blood. Instead, it's broken down into several components which are transfused in different clinical scenarios. The issues of storage and...

As you have noted, the "paroxysmal" stage of a clinical case of pertussis, which involves the rapid, exhausting coughing fits and the characteristic "whoop" at the end can often be extremely long. While it usually lasts 1-6 weeks, it can persist for up to 10 weeks , followed by a convalescent period. One reason for the long duration of the cough is that by the time one has reached that phase of disease, they are largely beyond the help of antibiotics, which will not shorten the clinical course of the disease in infected patients , but are intended to prevent...

Because leprosy and multiple myeloma are conditions for which other treatment options are limited. All treatments have side effects, some more debilitating than others. The trick with pharmacology is to balance the benefit of treatment with the hazards of the side effects. Take cancer chemotherapy. The drugs we use for cancer chemotherapy are horrible poisons. We literally use derivatives of chemical weapons to treat cancer. Why do we deliberately poison cancer patients with what amounts to a weapon of mass destruction? Because if we don't, the cancer will kill them. In pharmacology there's a concept of a therapeutic window ....

There is evidence that neonatal circumcision saying that the benefits of circumcision outweigh the risks. According to a study done on neonatal circumcision [1] , the lifetime benefits of being circumcised outweighed the risks 100 to 1. Some of the risks people may associate with circumcision are very unlikely. Excessive bleeding only happens 0.1% of the time, infections 0.02% of the time, and loss of penis 0.0001% of the time. The percentage of death is only 0.00001%. Overall, it shows that males who have been circumcised require half as much medical attention as males who have not been circumcised. Also,...


I have read (a long time ago, in an old book) that butter is good for burns. Is this true, and if so what is it that helps? Is salted or unsalted butter better? And how should it be applied, and kept there?

I think a missing bit of information that might help you get a better sense of this practice is: steroids are miracle drugs. OK, that was in jest - no miracles here. Truth be told, though, if there is a single class of drugs that has added more quality-adjusted life-years to human history than any other, steroids must be competing with just a few antibiotic classes for that title. To make clear what we’re talking about, the term “steroid” as a label for drugs generally refers to glucocorticoids (GCs) - drugs that act like cortisol, an endogenous steroid hormone. Commonly...

Short anwser : Never put butter, oil, etc , on a burn. This would worsen the burn. Putting butter, oil, or anything else would trap heat and make the burn deeper. It would also make further treatment harder and would make the risk of infection higher : Don’t apply burn ointments. Like butter (or mayonnaise), these ointments, usually oil-based, won’t relieve pain but instead will trap heat, slow down healing, and increase the risk of infection. What to do instead : Once it happens, a burn is actually "cooking inside", and this for a while after the exposure, so the...

Note: The following is excerpted from an article written in 2005. For lay (Non trained) people, there are more updated recommendations. The following is an example of the process, not the current recommendations. To be effective, CPR must restore adequate coronary and cerebral blood flow. Interruptions in chest compressions lower coronary perfusion pressure and decrease rates of survival from cardiac arrest. In the first minutes of VF SCA, ventilation does not appear to be as important as chest compressions, but it does appear to contribute to survival from prolonged and asphyxial arrest. Certainly the ventilation rate needed to maintain a...

This has been a controversial dispute for a long time and it can involve a lot of personal opinion, but I will try to answer this as scientifically as possible. There hasn't been any viable evidence that vaccines do cause autism. Several different theories have been proposed on why vaccines could cause autism, such as the ingredient in some vaccines thimerosal being harmful, but these have all been disproved by many different experiments. Many reliable sources such as the CDC 1 says that there is no link between autism an vaccines. A 2011 report 2 from the Institute of Medicine...


Risks of blood donation with autoimmune diseases

People with autoimmune diseases are generally either forbidden or discouraged from donating blood. Example: People who have autoimmune diseases (such as autoimmune thyroid disease, ankylosing spondylitis) are advised not to donate blood. This is because there is a small risk of causing immune system disturbance and symptomatic disease in patients who receive blood from donors with autoimmune diseases. source Is there any more information in the literature about the cases? I'm especially interested in the "causing symptomatic disease in patients who receive blood" part.

The short version is that in 2016 the polio vaccine changed. A more thorough explanation requires some background on the immunology of polio and its vaccines, which is not straightforward. Polio virus is usually harmless, it reproduces in the gut and spreads through a fecal-oral route. In ~99% of infections it only causes mild diarrhea. In the remaining 1% of cases, however, it gets into the bloodstream and from there enters nerves, causing paralysis and/or respiratory failure. There are two types of vaccine: inactivated polio vaccine (IPV) and oral polio vaccine (OPV). IPV is a shot of killed virus particles...

The World Health Organization published a report entitled Blood Donor Selection: Guidelines on Assessing Donor Suitability for Blood Donation . Based on a review of scientific studies and other literature, it contains detailed recommendations for establishing blood donation programs, including which donors to accept or reject. It mentions several autoimmune diseases. From the non-communicable section (page 49), we have 5.1.4 Thrombocytopenia Individuals with thrombocytopenia should not be accepted as blood donors because of the risk of bleeding at the venepuncture site and because chronic thrombocytopenia may be associated with serious underlying haematological or other systemic disease. A past history of...

Because leprosy and multiple myeloma are conditions for which other treatment options are limited. All treatments have side effects, some more debilitating than others. The trick with pharmacology is to balance the benefit of treatment with the hazards of the side effects. Take cancer chemotherapy. The drugs we use for cancer chemotherapy are horrible poisons. We literally use derivatives of chemical weapons to treat cancer. Why do we deliberately poison cancer patients with what amounts to a weapon of mass destruction? Because if we don't, the cancer will kill them. In pharmacology there's a concept of a therapeutic window ....


Why is BMI related to the square of height?

I'm aware that the U.S. CDC defines BMI (Body Mass Index) as mass (in kg) divided by height squared (in meters squared.) The CDC then defines what ranges are considered underweight, healthy, or overweight broadly based on BMI (with different ranges by gender.) My question is: Why the square ? As any mechanical or civil engineer (or just anyone who is vaguely familiar with those topics) will know, if you scale something up proportionally, mass will scale with the cube of the increase in a particular dimension, not the square. Because, for a given material, mass is proportional to volume. Furthermore, since material strength usually scales with the cross-sectional area (not volume,) which is proportional only to the square of a particular dimension, making something larger usually requires scaling up supporting structures more than proportionally in order to maintain the same safety margins. (See: Square-Cube Law ) So, why are these principals not applied when dealing with human anatomy? Is there some reason why it isn't believed that humans should scale proportionally (or even super-proportionally in order to maintain similar load-bearing characteristics?)

I think a missing bit of information that might help you get a better sense of this practice is: steroids are miracle drugs. OK, that was in jest - no miracles here. Truth be told, though, if there is a single class of drugs that has added more quality-adjusted life-years to human history than any other, steroids must be competing with just a few antibiotic classes for that title. To make clear what we’re talking about, the term “steroid” as a label for drugs generally refers to glucocorticoids (GCs) - drugs that act like cortisol, an endogenous steroid hormone. Commonly...

It turns out the answer to this is fairly simple, and but not terribly easy to find. In the 1800s a Belgian named Adolphe Quetelet (1796–1874) performed some statistics on the weights and heights of people in Europe and Britain (chiefly France and Britain) and published his seminal work, Sur l'homme et le développement de ses facultés, ou Essai de physique sociale (Treatise on Man and the Development of his Faculties, or Essays on Social Physics) in 1835. The relevant section for this can be found as a PDF for free (I believe) at the Wiley Publishing journal Obesity Research...


My young son keeps getting ear infections. The otolaryngologist want to perform surgery to put tubes in his ear drums. How does putting a tube in the ear drum help with the ear infections?

Ear tubes do many things to help ear infections. The most important things they do are draining the ear of fluid and ventilating the ear. Overall, this will help your child hear better. The tubes also stop fluid from building up behind the ear drum, which should help prevent the ear infections. Stuff to watch out for There is always the possibility of ear infections coming back after the 6-12 months that the tubes will be in. There is also a minor chance of hearing loss because of scarring of the ear drum. The tube can become blocked, stopping it...

I'm guessing the "iron" test was actually a hemoglobin test (though I'm certainly no expert in blood donation screens...). I suspect your nurse is reporting a folk tale rather than any true difference. Unfortunately, medical professionals are not always an excellent source of scientific knowledge. I looked for papers that have actually compared measurements in the two hands. Here's one: Patel, A. J., Wesley, R., Leitman, S. F., & Bryant, B. J. (2013). Capillary versus venous haemoglobin determination in the assessment of healthy blood donors. Vox sanguinis, 104(4), 317–323. https://doi.org/10.1111/vox.12006 Capillary fingerstick samples were assayed by HemoCue in 150 donors....

I think a missing bit of information that might help you get a better sense of this practice is: steroids are miracle drugs. OK, that was in jest - no miracles here. Truth be told, though, if there is a single class of drugs that has added more quality-adjusted life-years to human history than any other, steroids must be competing with just a few antibiotic classes for that title. To make clear what we’re talking about, the term “steroid” as a label for drugs generally refers to glucocorticoids (GCs) - drugs that act like cortisol, an endogenous steroid hormone. Commonly...


Does the usage of sunscreen cause skin cancer?

I have heard that usage of sunscreen products causes skin cancer. Is this true, and if so, what are the ingredients in it that are reason for such a medical condition. Are there any safe products or methods of application that they don't harm skin.

Assuming the person is not taking anticoagulants, it's actually quite difficult to bleed to death from dismemberment of small members (hands, feet, penis, ears, nose, etc). Even large members such as arms and legs are often survivable because the body is very good at protecting itself from blood loss. For example, transected arteries will spasm and clamp off blood flow, and loss of blood will cause the body to divert blood flow away from the extremities and to the vital organs, thereby slowing the bleeding and allowing it to clot. In fact, the whole shock process can be viewed as...

The potential health risks of sunscreen include: The absence of UVA filters combined with a longer exposure time of the sunscreen user 1995 , 2005 , 2007 , 2007 . Suppression of the skin's production of melanin, a natural broad-spectrum photoprotectant 1995 , 2004 . Skin penetration (free radical generation) by sunscreen chemicals 1996 , 1997 , 2006 , 2007 . Cytotoxic and carcinogenic effects of nanoparticles (zinc oxide (ZnO) and titanium dioxide (TiO2) toxicity) 1999 . However TGA study from 2006 ( PDF ) concluded: There is evidence from isolated cell experiments that zinc oxide and titanium dioxide can...

In general, the benefit of flu shots is to the general population. Taking the cited value of 40%-60% from the CDC, we can say that it might be a coin toss for you personally to be protected from influenza by the shot. However, if many thousands of people take the flu shot, even if it only works on 40% of them, it helps protect the remaining population from the spread of the virus (AKA herd immunity). This is especially important to those within the population who cannot access the shot or cannot receive it due to a preexisting medical condition....


What forms of prevention of STIs are there?

Other than the condom, are there any other methods of preventing contracting STIs? If so, do any of these also provide an effective form of contraception?

Most dentists - for most procedures - aim for a painless experience. If there is reason to keep some pain sensation intact, the dentist will inform you, and ask at appropriate intervals if you can feel pain. The efficacy of lidocaine and other local anesthetics depends on how closely your nerve distribution comes to the norm (they will inject the environs of the "normal" anatomical position of the nerve), how much anesthetic is injected, whether there are local factors which alter the local tissue pH (e.g. presence of an abscess or infection), how quickly it is removed from the site,...

The CDC lists two: complete abstinence, and being in a long-term mutually monogamous relationship with an uninfected partner . Sexual intercourse naturally introduces microtears (small tears in the the epithelial layer) through which diseases can transfer between partners. One might think that additional lubrication would help with this, but the jury is most definitely out on that. I think it's pretty safe to say that if there was another clinically verified way of preventing STDs, the CDC would have put it on this list . (For example, they note that there are specific things you can be vaccinated against, namely...

Products high in calcium and magnesium should not be taken at the same time as antibiotics of the tetracycline (tetracycline, doxicycline, etc.) class, and milk should also be avoided with the quinolone class. They have the ability to bind the antibiotic in the gut, decreasing absorption. There is no reason to avoid dairy products while taking other antibiotics (such as the penicillin class, the one you're taking. The clavulanic acid is to increase it's strength against certain bacteria.) If the antibiotic package insert (or the pharmacists's instruction sheet) states it should be taken on an empty stomach, take it with...

Race and ethnicity are risk factors in many diseases. Examples include, but are not limited to, cystic fibrosis and spinal muscular atrophy. There is also an epidemiological purpose of collecting this information. It is important to know if some disease is affecting some races or some ethnicities disproportionately. This is how it was found out that race or ethnicity is a risk factor in certain diseases in the first place. RFERENCES: Sheets L, Johnson J, Todd T, Perkins T, Gu C, Rau M. Unsupported labeling of race as a risk factor for certain diseases in a widely used medical textbook....


Vitamin B12 is stored over a very long time such that vegans, for example, only get any signs or symptoms of B12 deficiency after a span of years, even though they have hardly any sources of the vitamin in their diets. The dose required daily to prevent disease seems to vary dramatically, or maybe it is very hard to determine accurately. For example: This site says pregnant women need less than 3 micrograms (µg)/day (where pregnant women need more than non-pregnant women). A friend of mine got her blood values in order by ingesting 7 µg/day. My apothecary person told me 500-1000 µg per day are needed to even start absorbing meaningful quantities by ingestion. My doctor prescribed 200 µg/day for me. Another factor is that apparently your intestinal bacteria determine the rate of absorption. So what is the amount of B12 needed per day? Please note that this is not about deficient absorption, where the amount would be above what healthy people need.

obstetrics b-12-supplements absorption-absorb apothecary prenatal-vitamins

The estimated daily requirement needed to maintain body stores of B12 varies, an estimate being from 2µg to 5µg, more if stores have been depleted in any way. It is estimated that the average person stores about 1 mg (1000 µg) of B12 in their liver, and other smaller amounts elsewhere. The recommended daily allowance assumes a 50% absorption rate of ingested B12. This is a good question to discuss the limits of medical science. How is the requirement for B12 determined? Longitudinal studies are those that follow people over many years (even decades.) Humans are not subjected to longitudinal...


Do adult braces have a medical need beyond cosmetics?

While middle/upper-class American parents often have their children get braces as teenagers, an adult getting braces out of his/her own volition could be viewed as a sign of vanity, much like plastic surgery. While in most communities, braces are seen as more socially acceptable than plastic surgery, both involve modifying the body to improve outward appearance to gain the attraction and respect of others. Do adult braces have a medical needs, are are they purely to alter cosmetic appearance?

dentistry cosmetics dental-braces teeth-alignment

In the blister shown, the likelihood of rupture is decreased because of the thickness of the epidermis on the palm of the hand, so you can leave it alone until the underlying area re-epithelializes. You'll know this is happening because of the decreased pain and the slow reabsorption of the fluid. Eventually you will just peal it off what's left of the blister, finding clean new skin underneath. But this is a great starting point for an answer about the treatment of blisters in general: is it better to leave them alone, drain the fluid, or de-roof them (take the...

There are certain types of malocclusion that are have been shown to adversely affect quality of oral health and quality of life, but these are far, far fewer than the number of people sporting braces, adult or adolescent. The need for braces in the average teen, therefore, is no greater than the average adult. If you think of braces for teens as a necessity, it is no less a necessity for adults, that is, appearance is probably the only significant result for both average teens and adults. However, increased longevity has led to the need to keep healthy teeth for...


Does keeping different types of medications in one pill bottle affect their quality?

I take a number of different medications and herbal supplements. Because keeping separate containers in my pocketbook is cumbersome, I've been combining them together in the same prescription bottle. I'm wondering if this alters or diminishes their effectiveness. The combination includes: regular tablets, some of which have been cut in half; coated tablets; and capsules. The capsules are clear, made of plant-based hypromellose, and are filled with either powdered medication or ground herbs. There are no gel-caps or anything containing liquid. There's usually some fine powder in the bottom of the bottle, which I assume comes from the broken pills. Other than that, everything appears intact and not misshapen, stuck together, or otherwise compromised. Is there an overarching rule of thumb for this situation, or would it depend on the specific medications?

No, this does not alter them, or make them less effective. There are problems with a scant amount of medicine crumbling, as you've noticed. The only real concern I'd have for anyone doing this is regarding the authorities: for example, while traveling out of the country, it's good to keep your medicines in their original prescription bottles because it supports you're assertion that the medicines are all prescribed to you . In my entire life, I had only one border agent question my medications. So even there, it's rare. As long as you can tell which pill is which, this...

This has been a controversial dispute for a long time and it can involve a lot of personal opinion, but I will try to answer this as scientifically as possible. There hasn't been any viable evidence that vaccines do cause autism. Several different theories have been proposed on why vaccines could cause autism, such as the ingredient in some vaccines thimerosal being harmful, but these have all been disproved by many different experiments. Many reliable sources such as the CDC 1 says that there is no link between autism an vaccines. A 2011 report 2 from the Institute of Medicine...

Products high in calcium and magnesium should not be taken at the same time as antibiotics of the tetracycline (tetracycline, doxicycline, etc.) class, and milk should also be avoided with the quinolone class. They have the ability to bind the antibiotic in the gut, decreasing absorption. There is no reason to avoid dairy products while taking other antibiotics (such as the penicillin class, the one you're taking. The clavulanic acid is to increase it's strength against certain bacteria.) If the antibiotic package insert (or the pharmacists's instruction sheet) states it should be taken on an empty stomach, take it with...


I have been a nocturnal for some period of time and thus altering the sleep cycle seems difficult i.e. moving back to the normal 10 to 5 sleep cycle. What can be done to revert back to the normal sleep cycle? Should I need to skip a day of sleep or you recommend any health hack?

There are quite a few things you can do to "reset" your sleep schedule, as shown by this WebMD article . However, be aware that due to your own circadian rhythms, that may not be the optimal pattern for you. Some of the suggestions include: Bright lights - Use bright lights around you when you first get up. Dim lights - Conversely, use dim lights in the evening. Don't lay awake - If you tend to lay awake for a while, do something else before you go to bed. Time meals - Use your meal times to help your body...

Let's get a few things out of the way... Sex is normal ( 1 ). Sexual desire and arousal are normal ( 2 ). Asexuality is normal ( 3 ). Masturbation is normal ( 4 ),( 5 ). There is no problem whatsoever with these three things, although everyone blushes when they talk about them. Is Masturbation healthy? Downsides : Masturbation is not risk free. It is about as dangerous as chewing or walking ( 6 ). Some side effects are irritated skin and ruptured penis, but only if you really, really, really overdo it (Once or twice a day...


Can an antipyretic (I.e. Aspirin) lower normal body temperature?

Is it possible for an antipyretic medication taken when not experiencing fever to cause a person's body temperature to drop below normal? I found one article that seems to say yes, but only for large doses (in mg/kg) in mice.

The MSDS linked to is for a product sold as a solution of 10% SM-102 in 90% chloroform. It's listed as "SM-102" because that's the interesting/useful thing that the company is selling. It's common for chemicals to be sold packaged with solvents to make a solution. Sometimes that solvent is just water, but if the product is not water-soluble in sufficient concentrations then other solvents may be necessary. Alcohol solutions are quite common, but for more hydrophobic chemicals it may be necessary to use more "exotic" solvents. Because chloroform is quite a dangerous chemical for people to be exposed to...

It is not possible. The regulation of human body temperature (thermoregulation) is very subtle. Wikipedia article about thermoregulation contains a very nice graph about that mechanism. The labels are not described in the text in detail and the reference in the caption does not include this picture. Picture is a work by one JW Dietrich and I also searched PubMed for this guy, but he has no works on this topic. Another more pragmatic picture is here. Fever or increased body temperature is almost solely caused by to the production prostaglandin E2 (PGE2) . PGE2 acts on the hypothalamus or...


Laptops in the dark and miscalculating bats: how dangerous is that for rabies?

A few nights ago, during a township-wide power failure, I was using my laptop outside in the dark. Because mine was one of very few lights for many acres, a more than usual number of moths and other insects were flying around in the light it was emitting, but unfortunately I didn't think anything about this from a bat's perspective. Suddenly (and incredibly silently) something flew into my face, completely blocking my vision momentarily. I thought at first that it was a giant moth, but it was too fast for a moth, and besides, it flew away immediately. But it took a few moments to realize that it was the wing of a flying bat that had basically hit me in the face. I had no scratches, no blood, didn't feel any fluid when it hit me, and I washed myself well. About 15 years ago, I was exposed to the saliva of a known rabid animal and had completed a post-exposure prophylaxis series of 5 vaccines as well as getting a rabies immune globulin shot, so I wasn't overly concerned. * I know that any significant first exposure to a potentially rabid animal, or a possible rabies-vector (bats, raccoons, skunks, foxes, etc.) merits a visit to an emergency room and immunization. But what about this situation? Are there clear guidelines about post-exposure prevention in people who have been previously immunized? * From that night on, when using my laptop outside at night, I make sure to turn on an outdoor light brighter than my computer screen.

This event occurred in the US. In the US, enzootic (dog-to-dog) canine rabies virus has been virtually eliminated through vaccination and stray control programs, making wild animals the primary concern. It is quite true, as @EMT_Jedi stated, that rabies is usually caused by an animal's saliva, usually introduced by a bite (e.g. rabid cats, raccoons, etc.) However, this is not true of bat-related rabies. There is reason to be vaccinated after any strange contact with a bat. The most dangerous and common route of rabies exposure is from the bite of a rabid mammal. An exposure to rabies also might...

The short version is that in 2016 the polio vaccine changed. A more thorough explanation requires some background on the immunology of polio and its vaccines, which is not straightforward. Polio virus is usually harmless, it reproduces in the gut and spreads through a fecal-oral route. In ~99% of infections it only causes mild diarrhea. In the remaining 1% of cases, however, it gets into the bloodstream and from there enters nerves, causing paralysis and/or respiratory failure. There are two types of vaccine: inactivated polio vaccine (IPV) and oral polio vaccine (OPV). IPV is a shot of killed virus particles...


If a SARS-CoV-2 asymptomatic infected individual is exposed to a high viral load, could they develop COVID-19 disease?

I would add my own research if I could to respect site rules, but I can't. There are no studies on SARS-CoV-2, all I can find is for SARS-CoV-1 and some Chinese information based studies. My government is planning to do massive testing (when tests are available) and transfer and isolate every asymptomatic person in buildings such as hotels. The right is in arms saying this is like gulags and saying now they don't want to do the test. My question, I hope generically, is: if someone is infected but asymptomatic, could the exposure to a high virus load lead to COVID-19 disease? Or conversely: if your immune system is already coping well with the virus, the addition of more virus load can't worsen your diagnosis.

What your government is proposing is a lot less than what was actually done in China. There, and perhaps that is still the case, large numbers of asymptomatic infected people were housed together in halls with only social separation between them, and masks to prevent others from infecting others. Your government is proposing to house the asymptomatic infected in hotels, presumably in separate rooms. We know that people who are infected because they have virus identified using PCR swabs of their upper airways. CT scans can show pulmonary lesions present even without cough or fever. And even speaking can aerosolize...

Because leprosy and multiple myeloma are conditions for which other treatment options are limited. All treatments have side effects, some more debilitating than others. The trick with pharmacology is to balance the benefit of treatment with the hazards of the side effects. Take cancer chemotherapy. The drugs we use for cancer chemotherapy are horrible poisons. We literally use derivatives of chemical weapons to treat cancer. Why do we deliberately poison cancer patients with what amounts to a weapon of mass destruction? Because if we don't, the cancer will kill them. In pharmacology there's a concept of a therapeutic window ....

Short answer: Sophie Trudeau's positive test may still mean 3 : 1 odds of not having contracted Covid-19, but the odds could also be far more towards having Covid-19. Justin Trudeau's negative test almost certainly means he was negative when tested. Of course, should Sophie be positive, that may have changed by now. Update: I found a web page of the FDA listing tests that have this Emergency Use Approval . Each of them has manufacturer instuctions that list their test results towards the end. Some of the submitted test results use ≈100 negative samples in the clinical evaluation. But...

Ear tubes do many things to help ear infections. The most important things they do are draining the ear of fluid and ventilating the ear. Overall, this will help your child hear better. The tubes also stop fluid from building up behind the ear drum, which should help prevent the ear infections. Stuff to watch out for There is always the possibility of ear infections coming back after the 6-12 months that the tubes will be in. There is also a minor chance of hearing loss because of scarring of the ear drum. The tube can become blocked, stopping it...


A cheap and easy inactivated vaccine for COVID-19

Suppose a person with COVID-19 coughs into a bag. Let the bag sit in the sun for, say, 72 hours -- so as to make the virus inactive . Could a healthy person breathe in the inactivated virus from the bag (perhaps done multiple times) to (eventually) trigger an antibody response to the virus? Is this a known way to make inactivated vaccines ? Has it been studied, perhaps for other viruses? Are there known reasons why this would not work?

covid-19 virus vaccination infectious-diseases antibodies

The only approved inhaled vaccine is the flu vaccine delivered intra-nasally. It uses a live attenuated virus. There are a whole list of people who should not receive it because it's a live virus, and it works better for children, but only is 40% effective for adults. The main issue is The intranasal LAIV, recommended for children above the age of 2 years, induces a broader immune response wherein protection is not antibody mediated and probably involves undefined multiple correlates of protection. and that's with a live virus. How well would a dead inhaled virus work? Well, we have some...

It turns out the answer to this is fairly simple, and but not terribly easy to find. In the 1800s a Belgian named Adolphe Quetelet (1796–1874) performed some statistics on the weights and heights of people in Europe and Britain (chiefly France and Britain) and published his seminal work, Sur l'homme et le développement de ses facultés, ou Essai de physique sociale (Treatise on Man and the Development of his Faculties, or Essays on Social Physics) in 1835. The relevant section for this can be found as a PDF for free (I believe) at the Wiley Publishing journal Obesity Research...


Why use a placebo in some potential COVID-19 vaccine trials?

With potential COVID-19 vaccine trials beginning around the globe, one vaccine approach is to induce the creation of antibodies in the participants. The first phase of the trial will check whether the vaccine candidate induces the creation of antibodies to kill the coronavirus that causes COVID-19, and whether it provokes any serious adverse side effects. Either the potential vaccine or a placebo will be given to participants. Two doses of COVAX-19, or a placebo, will be injected into 40 healthy people between the ages of 18 and 65 As the aim of the trial is to check for the creation of antibodies, what is the purpose of having a placebo group? Would it be a reasonable assumption to conclude that it's biologically impossible for the antibody to be created in the participant on placebo? A standard example of the placebo effect would be in pain management - wherein participants will be given a painkiller or a sugar pill. There do exist known mechanisms for these effects, however in the case of creating an antibody - how can that be possible?

Let's get a few things out of the way... Sex is normal ( 1 ). Sexual desire and arousal are normal ( 2 ). Asexuality is normal ( 3 ). Masturbation is normal ( 4 ),( 5 ). There is no problem whatsoever with these three things, although everyone blushes when they talk about them. Is Masturbation healthy? Downsides : Masturbation is not risk free. It is about as dangerous as chewing or walking ( 6 ). Some side effects are irritated skin and ruptured penis, but only if you really, really, really overdo it (Once or twice a day...

Most dentists - for most procedures - aim for a painless experience. If there is reason to keep some pain sensation intact, the dentist will inform you, and ask at appropriate intervals if you can feel pain. The efficacy of lidocaine and other local anesthetics depends on how closely your nerve distribution comes to the norm (they will inject the environs of the "normal" anatomical position of the nerve), how much anesthetic is injected, whether there are local factors which alter the local tissue pH (e.g. presence of an abscess or infection), how quickly it is removed from the site,...

People could develop antibodies from natural exposure to the virus. The vaccine is trying to cause antibodies to exist in more people (and/or more strongly) than would express them naturally, therefore a good comparison group is a sample taken randomly in the same way as those getting the vaccine: a placebo group. At the same time, these trials tend to assess safety outcomes; again, to assess safety you want to know that effects are no worse than those in some comparison population. Comparing to placebo is typically a gold standard for this comparison. You're right that a placebo wouldn't be...


Rapid Response COVID-19 Antigen Test: What can be assumed by the control bar?

Rapid COVID-19 antigen tests include a control line similar to this: From Case Western Reserve rapid testing instruction available here . What does the control bar/strip control for? All the chemicals required to test for COVID are present in acceptable concentrations. If there is COVID on the swab this test will show it. Other Indicators that should be present when the swab is correctly done have been identified. You have correctly swabbed and if you have COVID this test will show it. Both. This test is in good standing condition and you have properly swabbed. If you have COVID this will show it. Since this test was distributed to the general public and there was little to no information about what the control bar/strip meant or did in the included documentation I was under the impression that option 3 was the most probable. *All statements above assume no false positives or false negatives which I know can happen.

Your explanation numbered 1 is correct. The control line indicates that the antibodies required to detect the SARS-CoV-2 (the virus that causes COVID-19) particles have reached that location on the test strip. Each product is slightly different, but the Rapid Response package insert notes: Anti-SARS-CoV-2 antibodies are immobilized on the test region of the nitrocellulose membrane. Anti-SARS-CoV-2 antibodies conjugated to coloured particles are immobilized on the conjugated pad. A sample is added to the extraction buffer which is optimized to release the SARS-CoV-2 antigens from specimen. During testing, the extracted antigens bind to anti-SARS-CoV-2 antibodies conjugated to coloured particles. As...

It turns out the answer to this is fairly simple, and but not terribly easy to find. In the 1800s a Belgian named Adolphe Quetelet (1796–1874) performed some statistics on the weights and heights of people in Europe and Britain (chiefly France and Britain) and published his seminal work, Sur l'homme et le développement de ses facultés, ou Essai de physique sociale (Treatise on Man and the Development of his Faculties, or Essays on Social Physics) in 1835. The relevant section for this can be found as a PDF for free (I believe) at the Wiley Publishing journal Obesity Research...

I think a missing bit of information that might help you get a better sense of this practice is: steroids are miracle drugs. OK, that was in jest - no miracles here. Truth be told, though, if there is a single class of drugs that has added more quality-adjusted life-years to human history than any other, steroids must be competing with just a few antibiotic classes for that title. To make clear what we’re talking about, the term “steroid” as a label for drugs generally refers to glucocorticoids (GCs) - drugs that act like cortisol, an endogenous steroid hormone. Commonly...

This event occurred in the US. In the US, enzootic (dog-to-dog) canine rabies virus has been virtually eliminated through vaccination and stray control programs, making wild animals the primary concern. It is quite true, as @EMT_Jedi stated, that rabies is usually caused by an animal's saliva, usually introduced by a bite (e.g. rabid cats, raccoons, etc.) However, this is not true of bat-related rabies. There is reason to be vaccinated after any strange contact with a bat. The most dangerous and common route of rabies exposure is from the bite of a rabid mammal. An exposure to rabies also might...


Dietary Factors for Calcium Oxalate Kidney Stones

Is there any evidence that diet factors play a big role in the creation of calcium oxalate kidney stones? Some doctors and other sources recommend cutting out coffee, tea, soft drinks, and dietary calcium to reduce the risk of stones. Other sources seem to recommend cutting out dietary items that increase oxalate levels. It seems that scientists have a good understanding of how kidneys function, yet there doesn't seem to be a consensus for dietary recommendations for these types of stones. The most obvious answer would seem to be water consumption. The less water one consumes, the less dilute the urine in the kidney becomes.

There is evidence that neonatal circumcision saying that the benefits of circumcision outweigh the risks. According to a study done on neonatal circumcision [1] , the lifetime benefits of being circumcised outweighed the risks 100 to 1. Some of the risks people may associate with circumcision are very unlikely. Excessive bleeding only happens 0.1% of the time, infections 0.02% of the time, and loss of penis 0.0001% of the time. The percentage of death is only 0.00001%. Overall, it shows that males who have been circumcised require half as much medical attention as males who have not been circumcised. Also,...

I'm guessing the "iron" test was actually a hemoglobin test (though I'm certainly no expert in blood donation screens...). I suspect your nurse is reporting a folk tale rather than any true difference. Unfortunately, medical professionals are not always an excellent source of scientific knowledge. I looked for papers that have actually compared measurements in the two hands. Here's one: Patel, A. J., Wesley, R., Leitman, S. F., & Bryant, B. J. (2013). Capillary versus venous haemoglobin determination in the assessment of healthy blood donors. Vox sanguinis, 104(4), 317–323. https://doi.org/10.1111/vox.12006 Capillary fingerstick samples were assayed by HemoCue in 150 donors....

Background Most kidney stones (~80%) are calcium stones, and the majority of those are primarily composed of calcium oxalate. Oxalate (C 2 O 4 2− ) is a dianion that combines with divalent cations such as magnesium and calcium. The magnesium salt is much more soluble than the calcium salt. Because these cations compete for binding to oxalate, both lower magnesium levels and higher calcium levels will tend to cause precipitation (movement out of solution into crystalline form) of calcium oxalate. When this happens in the urine in large enough quantities, it can form “stones.” Does diet matter? As introduced...


What are pros and cons of different approaches to aborting ventricular tachycardia?

Idiopathic (or spontaneous, unknown origin) ventricular tachycardia is a type of ventricular tachycardia (VT) that occurs in patients with structurally normal hearts. I would like to know what the pros and cons are of the three main corrective actions physicians seem to prefer: Verapamil : This seems like the drug of choice, but it tends to cause a drop in blood pressure (BP). If the patient already has a low BP (even if merely because of being young and fit), providers may be reluctant to give this drug fearing a significant drop in BP. Amiodarone : This is a drug with significant toxicity that stays in your system for a long time ( weeks to months ). Defibrillation : Assuming the patient returns to normal rhythm after the treatment and is not conscious when delivered, it seems to have less side effects than the drugs. I have looked around and have not found any negative long term side effects, but short term ( seconds to minutes ) there are some risks. My research so far is inconclusive on what the least harmful long term impact of the three are. I am pretty sure Amiodarone should be a last choice, but unsure about the other two. What are the pros and cons of these treatment options that a patient diagnosed with idiopathic VT should understand?

Please see the following society guidelines first: The 2006 American College of Cardiology/American Heart Association/European Society of Cardiology (ACC/AHA/ESC) guidelines: ●There is evidence and/or general agreement supporting RF ablation in patients with symptomatic idiopathic VT that is drug-refractory, or in such patients who are intolerant of drugs or do not desire long-term drug therapy. ●The weight of evidence and/or opinion supports the use of beta blockers and/or calcium channel blockers for the treatment of symptomatic idiopathic VT. ●The weight of evidence and/or opinion supports the use of class IC antiarrhythmic drugs as an alternative to or in combination with beta...

In the blister shown, the likelihood of rupture is decreased because of the thickness of the epidermis on the palm of the hand, so you can leave it alone until the underlying area re-epithelializes. You'll know this is happening because of the decreased pain and the slow reabsorption of the fluid. Eventually you will just peal it off what's left of the blister, finding clean new skin underneath. But this is a great starting point for an answer about the treatment of blisters in general: is it better to leave them alone, drain the fluid, or de-roof them (take the...


I have noticed that every time I am in the same room as an operating ultrasound machine, I can hear it. And not the machine making noises, but the actual ultrasounds (I know because it decreases in intensity after the gel is added). 'Ultrasound' refers to sound waves with a frequency too high for humans to hear (Wikipedia). Except, it seems, for me. Simply, my question is, "Is this normal?"

It is likely you are not hearing the ultrasound itself (typical frequencies are upwards of 1 MHz , far beyond what the human hearing system is capable of detecting). You are probably hearing coil whine from the electronics -- switched-mode power supplies in particular tend to operate towards the upper end of the hearing range, and the intensity of this sound changes as the power consumption does (eg. when the imaging system goes from "idle" to "active").


What do blood pressure readings indicate?

I have heard 120 by 80 is considered normal blood pressure. What do these numbers indicate? I am not a science student. Please explain in non-complicated language.

I would like to add a brief answer in common language. The heart is a pump which pushes blood into the arteries in pulsatile manner (pushes out blood with each heart beat). As the blood is pushed in the arteries, the pressure rises to a peak called systolic pressure, which is usually around 120 mm Hg. As the heart's main chamber (left ventricle) relaxes, the pressure tends to fall. But fall in pressure is arrested by closure of a valve called aortic valve. Further fall in pressure occurs by flow of blood to peripheral tissues. The lowest limit to which...

Great question! I think it's answerable as an overview, but please know this is only the tip of the iceberg.* Summary : Yes, we have deficits of certain blood products in certain locations at certain times that affect patient care. However, a small percentage of blood product does expire unused (because it wasn't the right product [see background] in the right place at the right time). A little background Donated blood is not usually transfused into a patient as whole blood. Instead, it's broken down into several components which are transfused in different clinical scenarios. The issues of storage and...

I'm guessing the "iron" test was actually a hemoglobin test (though I'm certainly no expert in blood donation screens...). I suspect your nurse is reporting a folk tale rather than any true difference. Unfortunately, medical professionals are not always an excellent source of scientific knowledge. I looked for papers that have actually compared measurements in the two hands. Here's one: Patel, A. J., Wesley, R., Leitman, S. F., & Bryant, B. J. (2013). Capillary versus venous haemoglobin determination in the assessment of healthy blood donors. Vox sanguinis, 104(4), 317–323. https://doi.org/10.1111/vox.12006 Capillary fingerstick samples were assayed by HemoCue in 150 donors....


Safety of using a luggage with the prop. 65 warning

I recently bought a luggage set from Nautica and it came with a "California 65 warning: This product contains chemicals known to the state of California to cause cancer and/or birth defects or other reproductive harm." Is it safe to use? I won't "eat" the luggage or anything similar, but is it possible to be affected just by being in contact with it? I know that many products receive this warning in California, but it doesn't specify how carcinogen it is.

Products high in calcium and magnesium should not be taken at the same time as antibiotics of the tetracycline (tetracycline, doxicycline, etc.) class, and milk should also be avoided with the quinolone class. They have the ability to bind the antibiotic in the gut, decreasing absorption. There is no reason to avoid dairy products while taking other antibiotics (such as the penicillin class, the one you're taking. The clavulanic acid is to increase it's strength against certain bacteria.) If the antibiotic package insert (or the pharmacists's instruction sheet) states it should be taken on an empty stomach, take it with...

A California Proposition 65 warning doesn't really tell you anything about the safety of the luggage. Proposition 65 requires warnings if somebody may be exposed to a substance that has a 1 in 100,000 chance of causing cancer over the course of 70 years, or has the possibility of causing birth defects or reproductive harm, as determined by the California Office of Environmental Health Hazard Assessment . However, there is nothing preventing warnings even if there is no risk whatsoever. Proposition 65 permits members of the general public to sue over missing warnings, and California has a cottage industry of...


Why is it so much harder to swallow pills than it is to swallow food?

I don't have any real trouble swallowing pills, and I do it several times a day. But when I try to swallow a pill without food or water in my mouth, it is a bit tricky. We're not talking about huge horse pills either, just regular, relatively small pills. I can swallow a whole raw oyster, which is the size of hundreds of pills combined, but a single little capsule or tablet is too much for me to consume without food or water? It feels like I am struggling to convince my tongue and throat to cooperate with me, and they don't trust my judgment in choosing what I should and shouldn't swallow. What is going on here? Is there some sort of physiological explanation for this? Note: I am fully aware that my tongue and throat don't have minds of their own, and are incapable of trusting or mistrusting me. I am merely trying to explain what it feels like.

It is not possible. The regulation of human body temperature (thermoregulation) is very subtle. Wikipedia article about thermoregulation contains a very nice graph about that mechanism. The labels are not described in the text in detail and the reference in the caption does not include this picture. Picture is a work by one JW Dietrich and I also searched PubMed for this guy, but he has no works on this topic. Another more pragmatic picture is here. Fever or increased body temperature is almost solely caused by to the production prostaglandin E2 (PGE2) . PGE2 acts on the hypothalamus or...

The human (and other animals) upper digestive tract is 'designed' to ingest relatively large (compared to most pills), soft, moist boluses. The muscles of the tongue and pharynx can propel these kinds of objects (including liquid) into the esophagus with ease, unless there is some specific pathology at work. Chewing also tends to naturally push food toward the swallowing position. The tablets and capsules you asked about, on the other hand, tend to be dry and hard and are not chewed. There is little for the tongue and throat muscles to 'grab' as they try to push the object back...


I can understand that our immune system may be weaker when we are cold (?), but since these viruses live inside a human body which internal temperature is constant over the year, why does the season make a difference? Moreover, we are never sick from the flu in summer, like it does not exist, yet the viruses reappear as soon as the cold season is back. If nobody was sick before winter, where are the viruses coming from? Do people with a constantly weakened immune system (e.g. AIDS) catch flu in summer too ?

disease-transmission influenza weather seasonal-allergies air-temperature

Your question contains a lot of misconceptions. A cure is definitely possible A cure could be found, proved, and proved safe, more quickly than a vaccine People and firms that could be working on cures are choosing to work on vaccines None of these are correct. Most virus-caused diseases have no cure: colds, Zika, Dengue, and so on. A tiny handful have treatments that can ease the course of the disease: you've heard of Tamiflu and so on. And some can be actually cured with medication. So the first assumption, that a cure exists to be found, is not a...

The IARC has concluded that cell phones are a "possible carcinogen" due to the amount of evidence going both directions. The gist of it is summarised on the website itself: Cell phones emit radiofrequency energy, a form of non-ionizing electromagnetic radiation, which can be absorbed by tissues closest to where the phone is held. The amount of radiofrequency energy a cell phone user is exposed to depends on the technology of the phone, the distance between the phone’s antenna and the user, the extent and type of use, and the user’s distance from cell phone towers. Studies thus far have...

This is a really interesting question, because it really isn't as easy as people being a bit more susceptible in the winter. There's no definitive answer yet. Influenza Seasonality: Underlying Causes and Modeling Theories says: In temperate climates, flu infections at whatever level of intensity are characterized by a flu season. In these areas, the disease is thought to exist at a low level throughout the year but exhibit a marked seasonal increase, typically during the winter months. Influenza epidemics and outbreaks occur in tropical areas as well, although the timing and impact are not as well defined The exact...

The definition of mortality rate that you've given does not match any practical definition I'm familiar with.* When people talk about the mortality rate of a disease, what they usually mean is the case fatality rate or the death-to-case ratio , which is simply defined as N d / N i , where N d is the number of deaths attributed to the disease over a given time period and N i is the total number of new cases of the disease observed during the same time period. By this definition, the current case fatality rate of 2019-nCov according to...


This study seems to indicate that some plant essential oils have antibacterial properties: In vitro antibacterial activity of some plant essential oils (BMC Complementary and Alternative Medicine) Out of 21 essential oils tested, 19 oils showed antibacterial activity against one or more strains. Cinnamon, clove, geranium, lemon, lime, orange and rosemary oils exhibited significant inhibitory effect. Cinnamon oil showed promising inhibitory activity even at low concentration, whereas aniseed, eucalyptus and camphor oils were least active against the tested bacteria. Does this mean that essential oils are a good alternative to alcohol-based disinfectant products for everyday use?

People could develop antibodies from natural exposure to the virus. The vaccine is trying to cause antibodies to exist in more people (and/or more strongly) than would express them naturally, therefore a good comparison group is a sample taken randomly in the same way as those getting the vaccine: a placebo group. At the same time, these trials tend to assess safety outcomes; again, to assess safety you want to know that effects are no worse than those in some comparison population. Comparing to placebo is typically a gold standard for this comparison. You're right that a placebo wouldn't be...

Your question contains a lot of misconceptions. A cure is definitely possible A cure could be found, proved, and proved safe, more quickly than a vaccine People and firms that could be working on cures are choosing to work on vaccines None of these are correct. Most virus-caused diseases have no cure: colds, Zika, Dengue, and so on. A tiny handful have treatments that can ease the course of the disease: you've heard of Tamiflu and so on. And some can be actually cured with medication. So the first assumption, that a cure exists to be found, is not a...

There are many essential oils and each can work differently and on different micro-organisms. They could affect the skin and mucous membranes in ways that are valuable or harmful. For example steam-distilled eucalyptus oil is used as a primary cleaning/disinfecting agent added to soaped mop and countertop cleaning solutions, however there are hundreds of species of eucalyptus and dozens are used as sources of essential oils, so products of different species differ greatly in characteristics and effects and also the products of the very same tree can vary grossly wiki . Some other studies show that tea tree oil is...


How effective was the 2014-2015 influenza vaccination?

I’m aware that the CDC released this abysmal report on the effectiveness of this year’s influenza vaccination, including data collected through Jan 30, 2015. In practical terms, this means the flu vaccine reduced a person’s risk of having to seek medical care at a doctor’s office for flu illness by 19%. However, this is missing much (possibly most) of the flu season. Are there more updated numbers on vaccine effectiveness and/or reports that include data from other (non-U.S.) locales with a similar flu season (i.e. temperate Northern Hemisphere)?

There have been no additional reports in the Morbidity and Mortality Weekly Report , which was where your original article points to regarding the efficacy of the flu vaccine. However, the most recent update on influenza activity within the United States, which was about a month later than your report, does not suggest there has been any mid-season change in the dominant circulating strains, so the early estimates are likely in the same area. The one thing that may change this is that a larger number of last season cases of influenza are typically caused by influenza B viruses, as...

I believe that those lines are craze lines. "Craze lines are merely cracks in the enamel that do not extend into the dentin." They occur because of stress in your teeth, ie: grinding your teeth, biting your nails, and even routine use of your teeth. What you've said also matches up with craze lines in that you don't experience any pain. Those craze lines aren't nearly as bad as some other teeth. Craze lines rarely lead to tooth breakdown, so you almost definitely won't have to get them replaced. There are some studies that say that craze lines may be...

The MSDS linked to is for a product sold as a solution of 10% SM-102 in 90% chloroform. It's listed as "SM-102" because that's the interesting/useful thing that the company is selling. It's common for chemicals to be sold packaged with solvents to make a solution. Sometimes that solvent is just water, but if the product is not water-soluble in sufficient concentrations then other solvents may be necessary. Alcohol solutions are quite common, but for more hydrophobic chemicals it may be necessary to use more "exotic" solvents. Because chloroform is quite a dangerous chemical for people to be exposed to...


I'm trying to link the signs and symptoms of eczema (especially atopic dermatitis) to its causes . In short, what is the mechanism of the disease? In an answer of another question about eczema , @anongoodnurse has said (bolded words added by me): Signs and symptoms: Eczema (or Atopic Dermatitis) is an incompletely understood skin disorder, in which the normal skin barrier function (permeability) is compromised, allowing the skin to dry out more than normal skin. Causes: The cause of the dryness in AD is thought by some to be (1) a deficiency of a naturally occurring fatty substance in the skin called ceramide. Others believe it's (2) an abnormal or missing protein which causes the skin barrier to be compromised, allowing allergens and irritants to cause immune responses more easily, triggering the itch/chronic inflammation (this might explain the response seen with topical steroids). If the cause is a deficiency of ceramide, what causes this cause? Ceramides are a family of waxy lipid molecules , so exactly which chemical is produced? Is it because the skin produces another kind of ceramide which has lower quality, or it does not produce enough? If the cause is an abnormal or missing protein, what causes this cause? What protein it is? Is that something related to T cells (recognising antigens) or B cells (producing antibodies)? Is it a skin problem or an immune system problem? Also, I heard from many sources that this is an immune system problem. And the source of this problem is the gut. They quote Hippocrates: "All disease begins in the gut" . Is that true? Will just eating healthy food, adding more probiotics, and applying moisturizer help the skin effectively?

dermatology immune-system digestion eczema

This has been a controversial dispute for a long time and it can involve a lot of personal opinion, but I will try to answer this as scientifically as possible. There hasn't been any viable evidence that vaccines do cause autism. Several different theories have been proposed on why vaccines could cause autism, such as the ingredient in some vaccines thimerosal being harmful, but these have all been disproved by many different experiments. Many reliable sources such as the CDC 1 says that there is no link between autism an vaccines. A 2011 report 2 from the Institute of Medicine...

This is a pretty old old-wives tale, taking many forms: don't go out into the cold while it's raining, or without a hat, with wet hair, without a warm coat or scarf, without boots, etc., "or you'll catch your death of cold." The old wive's tale was immortalized by Jane Austin in her book, Pride and Prejudice , when the heroine's sister Jane falls ill after getting a soaking in the rain. This has been studied extensively. A New York Times article describes one such uncomfortable-sounding study: In the 1950's, Chicago researchers repeated the experiment on a larger scale with...

TLDR: The pathogenesis of eczema is multifactorial, but broadly follows a process of genetic (or epigenetic, in the case of the early gut microbiome) dysregulation relating to barrier integrity proteins like filaggrin with corresponding changes in the skin microenvironment's ceramide content. Following these changes in protein structure and function and lipid quantity, the compromised barrier is predisposed to irritation and infection, which leads to an abnormal immunological response as Th2 cells work to resolve inflammatory processes in the skin (it's not clear how B cells participate in the pathogenesis of eczema at this time). Treatment options for mild-moderate eczema are...