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README.md
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# Extended-BioAgentBench
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Extension of [BioAgentBench](https://github.com/bioagent-bench/bioagent-bench) with 3 additional bioinformatics benchmark tasks covering new domains: epigenomics (ChIP-seq), bacterial genome assembly, and mobile genetic element characterization.
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## Tasks
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| # | Task ID | Domain | CLI Tools | DAG Depth | Difficulty |
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|---|---------|--------|-----------|-----------|------------|
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| 11 | chipseq-peak-calling | Epigenomics | trimmomatic, bwa, samtools, macs2, bedtools, deeptools | 2 | medium |
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| 12 | bacterial-assembly | Genome assembly + annotation | fastp, shovill, quast, busco, prokka, mlst, abricate | 2 | medium |
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| 13 | mobile-elements | Mobile genetic elements | fastp, shovill, prokka, isescan, integron_finder, amrfinder, abricate, mob_recon, plasmidfinder, quast, busco | 5 | hard |
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## Usage
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```bash
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# Install dependencies
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pip install requests click
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# List tasks
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python src/dataset.py list-tasks
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# Download a specific task
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python src/dataset.py download --task chipseq-peak-calling --reference --results
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# Download all tasks
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python src/dataset.py download --all --reference --results
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```
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## Task Format
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Each task follows the BioAgentBench format:
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```
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tasks/{task-id}/
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run_script.sh # Reference pipeline (ground truth generator)
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environment.yml # Conda environment specification
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data/ # Input data (FASTQ, BED, etc.)
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reference/ # Reference genomes (if needed)
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results/ # Ground truth output
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```
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## Evaluation
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Tasks are evaluated using GPT-5.1 as an LLM-as-Judge, scoring:
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- `steps_completed` / `steps_to_completion`
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- `completion_rate` (0-1)
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- `results_match` (full_match / partial_match / no_match)
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## Citation
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Based on BioAgentBench: https://arxiv.org/abs/2601.21800
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