#!/usr/bin/env python
"""Batch download misfolding target PDB structures for offline use.

Downloads all conformations from the misfolding knowledge base.
Stores PDB files in data/misfolding_targets/.
Generates a target_manifest.json for the pipeline.

Usage:
  python fetch_targets.py                # download all targets
  python fetch_targets.py --dry-run      # check what would be downloaded
  python fetch_targets.py --max 3        # max 3 conformations per target
"""

import sys
import os
import io
import json
import time
import argparse
from pathlib import Path

if sys.platform == 'win32':
    sys.stdout = io.TextIOWrapper(sys.stdout.buffer, encoding='utf-8')

PROJECT_DIR = Path(__file__).parent.parent
sys.path.insert(0, str(PROJECT_DIR))

from misfolding_knowledge_base import MISFOLDING_TARGETS
from misfolding_data_loader import prepare_misfolding_target, DATA_DIR


def main():
    parser = argparse.ArgumentParser(
        description='Download misfolding disease target PDB structures'
    )
    parser.add_argument('--dry-run', action='store_true',
                        help='Check what would be downloaded without downloading')
    parser.add_argument('--max', type=int, default=3, dest='max_confs',
                        help='Max conformations per target (default: 3)')
    parser.add_argument('--force', action='store_true',
                        help='Force re-download even if cached')
    args = parser.parse_args()

    total = 0
    success = 0
    failed = []

    print('=' * 70)
    print('Misfolding Disease Target PDB Downloader')
    print(f'Targets: {len(MISFOLDING_TARGETS)}')
    print(f'Max conformations/target: {args.max_confs}')
    print(f'Output dir: {DATA_DIR}')
    if args.dry_run:
        print('MODE: DRY RUN (no downloads)')
    print('=' * 70)

    manifest = {}

    for disease_key, target in sorted(MISFOLDING_TARGETS.items()):
        print(f'\n{"─" * 60}')
        print(f'[{disease_key}]')
        print(f'  Disease: {target["disease_cn"]}')
        print(f'  Protein: {target["protein"]} ({target["gene"]})')

        confs = target.get('conformations', {})
        conf_keys = list(confs.keys())[:args.max_confs]

        if not confs:
            print(f'  ⚠ No conformations defined — skipping')
            continue

        manifest[disease_key] = {
            'disease_cn': target['disease_cn'],
            'protein': target['protein'],
            'gene': target['gene'],
            'idp_flag': target.get('idp_flag', False),
            'conformations': {},
        }

        for conf_key in conf_keys:
            conf = confs[conf_key]
            total += 1
            pdb_id = conf['pdb_id']
            print(f'  [{conf_key}] PDB: {pdb_id} ({conf.get("type", "?")})')

            if args.dry_run:
                print(f'    → Would download from RCSB')
                manifest[disease_key]['conformations'][conf_key] = {
                    'pdb_id': pdb_id, 'status': 'dry_run'
                }
                success += 1
                continue

            if args.force:
                # Clear cache entry
                import misfolding_data_loader
                cache = misfolding_data_loader._load_cache()
                cache_key = f'{disease_key}_{conf_key}'
                if cache_key in cache:
                    del cache[cache_key]
                    misfolding_data_loader._save_cache(cache)
                print(f'    (forced re-download)')

            result = prepare_misfolding_target(disease_key, target, conf_key)

            if result['success']:
                print(f'    ✓ Downloaded → {result["pdb_path"]}')
                print(f'      Chain: {result["chain_id"]} | Resolution: {result["resolution"]}')
                if result['idp_warning']:
                    print(f'      ⚠ IDP warning: {result["idp_warning"][:80]}...')
                success += 1
                manifest[disease_key]['conformations'][conf_key] = {
                    'pdb_id': pdb_id,
                    'pdb_path': result['pdb_path'],
                    'chain_id': result['chain_id'],
                    'resolution': result['resolution'],
                    'status': 'ready',
                }
            else:
                print(f'    ✗ Failed: {result["error"]}')
                failed.append(f'{disease_key}/{conf_key}')
                manifest[disease_key]['conformations'][conf_key] = {
                    'pdb_id': pdb_id, 'status': 'failed',
                    'error': result['error'],
                }

            if not args.dry_run:
                time.sleep(0.4)

    # Save manifest
    manifest_path = DATA_DIR / 'target_manifest.json'
    with open(manifest_path, 'w', encoding='utf-8') as f:
        json.dump(manifest, f, indent=2, ensure_ascii=False)

    # Summary
    print(f'\n{"=" * 70}')
    print(f'SUMMARY')
    print(f'  Total conformations: {total}')
    print(f'  Success: {success}/{total}')
    if failed:
        print(f'  Failed ({len(failed)}):')
        for f in failed:
            print(f'    - {f}')
    print(f'  Manifest: {manifest_path}')
    print(f'{"=" * 70}')

    return 0 if not failed else 1


if __name__ == '__main__':
    sys.exit(main())