File size: 8,866 Bytes
6bcfe0e
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
smiles,score
COc1ccc([C@@H](C)NC(=O)Cc2cccc3ccccc23)cc1,0.5
O=[N+]([O-])c1c(Nc2ccc(F)c(F)c2)ncnc1Oc1cccc2cccnc12,0.5
CSc1ccc(/C=c2\sc3ncnn3c2=O)cc1,0.5
COc1ccc(F)cc1C(=O)Nc1nccs1,0.5
CCOCCCNC(=O)N[C@@H]1CCC[C@@H](CC)C1,0.5
C[C@H]1CCC[C@](C#N)([C@]2(O)CCCCC2(C)C)C1,0.5
C[C@H]1[C@@H](NC(=O)[C@@H](C)Sc2ncn[nH]2)CCC[C@@H]1C,0.5
Cc1c([C@H](C)[NH2+]Cc2cccn2C)cnn1C,0.5
C[C@@H]([C@@H](O)c1ccc2ncnn2c1)[N+](=O)[O-],0.5
Cc1c(C(=O)N2CCCC2)oc2c1-c1nn(CC(=O)N3C[C@H](C)C[C@H](C)C3)cc1CC2,0.5
C=C[C@](C)(O)CC[C@H]1C(C)=CC(=O)[C@H]2C(C)(C)CCC[C@]12C,0.5
CC(C)(C)OC(=O)N1CC[C@H]2CC(=O)[C@H]2C1,0.5
CC(C)CCc1noc(C[NH+](C)[C@H]2CCC[C@@H]2S(C)(=O)=O)n1,0.5
Cc1cc(C)c(C)c(S(=O)(=O)/N=C(\[O-])c2cc(C3CC3)n(C(C)(C)C)n2)c1C,0.5
C[NH+](C)CCSc1ccc(NC(=O)C2CC2)nn1,0.5
CC[C@@H](NC(=O)c1ccc(Br)o1)C(=O)N1CCOCC1,0.5
C=CCOc1ccc(CNc2ccc(OC)cc2)cc1,0.5
CC1=C(CNC(=O)c2cc(-c3ccccc3)nc3c2CNN3C(C)C)CN=N1,0.4928571428571429
C[C@H](CNC(=O)[C@H]1CC[NH2+][C@@H]1C)C[NH+]1CCCC1,0.4928571428571429
CN(Cc1ccno1)Cc1c(C(=O)N2CC[NH+](C3CCCCC3)CC2)nc2ccccn12,0.4928571428571429
N#Cc1ccc(-c2ccc(O[C@@H](C(=O)N3CCCC3)c3ccccc3)cc2)cc1,0.4857142857142857
Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N2C,0.4857142857142857
O=C(N[C@H]1CCS(=O)(=O)C1)C1CC[NH2+]CC1,0.4857142857142857
Cc1cccc(C2=CCN(C(=O)Nc3ccc(C(N)=O)c(Cl)c3)CC2)c1,0.4857142857142857
CCC[NH2+][C@]1(C(=O)OCC)CC[C@H](n2cc(Cl)c(C)n2)C1,0.4857142857142857
Cc1cc(C)cc(NC(=O)CC(C)C)c1,0.4857142857142857
C=CCn1c(SCC(=O)Nc2cc(C)on2)nnc1[C@H]1COc2ccccc2O1,0.4857142857142857
CNC(=O)Cc1nc(C[NH+](C)C2CCC(c3ccccc3)CC2)cs1,0.4857142857142857
c1csc([C@@H]2CN(Cc3cnc(C4CCC4)s3)CCO2)c1,0.4857142857142857
CC(C)CN(CCC#N)C(=O)NC[C@@H]1CC[C@H](C(=O)[O-])O1,0.4857142857142857
Cc1oc(-c2ccccc2)nc1CCNC(=O)c1ccc([S@@](C)=O)cc1,0.4857142857142857
CC(=O)C1=C([O-])C(=O)N(CCC2=c3ccccc3=[NH+][C@H]2C)[C@H]1c1ccccc1F,0.4857142857142857
NC(=O)[C@H](Nc1cccc(Oc2ccccc2)c1)c1ccc(F)cc1,0.4857142857142857
Cc1ccccc1OCC(=O)O[C@@H](C)c1nccs1,0.4857142857142857
CCCCOc1ccccc1C[C@@H]([NH3+])C(=O)[O-],0.4785714285714286
Cc1ccccc1N1C(=O)C[C@H]([NH+](C2CCCCC2)C2CCCCC2)C1=O,0.4785714285714286
Cc1c(F)cc(N)cc1S(=O)(=O)N[C@@H](C)C1CC1,0.4785714285714286
C/C=C/C[C@]1(C(=O)[O-])CCN(C(=O)OC(C)(C)C)C1,0.4785714285714286
CC(=O)NCCC(=O)N1CCC[C@@H](C)C1,0.4785714285714286
Cc1ccc(NC(=S)NC(C)C)cc1C,0.4785714285714286
C=CCO[C@H](C)C(=O)Nc1ccc(F)cc1Br,0.4785714285714286
Cc1nn(C)c(C)c1CN[C@H]1CCC[NH2+]C1,0.4785714285714286
COCCNC(=O)/C(C#N)=C/c1cccc(O)c1,0.4785714285714286
CCN(CC)C(=O)c1ccccc1OC(C)=O,0.4785714285714286
N#C/C(C(=O)NC1CCCC1)=C(/[O-])Cc1cnn(-c2ccccc2)c1,0.4785714285714286
N#CC1=C(SCC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2,0.4714285714285714
C[C@H](Cc1cccs1)N(C)C[C@@H]1CCCC[C@@H]1[NH3+],0.4714285714285714
Cc1ccc([C@]2([NH3+])CC[C@@H]2C)cc1,0.4714285714285714
Cc1ccc([N+](=O)[O-])cc1C(=O)Nc1ccc(C(=O)NC(C)C)cc1,0.4714285714285714
COC1CC[NH+](CCNc2nccn(C)c2=O)CC1,0.4642857142857143
CCCN(CC)c1cc[nH+]c(C(=O)[O-])c1,0.4642857142857143
Cc1cc2n(C[C@H](O)CO[C@H](c3ccccc3)c3ccccc3C)c(=O)c3ccccc3n2n1,0.4642857142857143
COCCn1nnnc1[C@@H](C(C)C)N1CCSCC1,0.4642857142857143
C[C@@H]1CCC[C@](O)(c2ccc(Cl)s2)CC1,0.4642857142857143
CC(C)c1nsc(NC[C@H](C2CC2)[NH+](C)C)n1,0.4642857142857143
C[C@@H]1CCC[C@H](C)N1C(=O)[C@@H]1COCCO1,0.4642857142857143
C[C@@H]1C[C@@H]1C(=O)Nc1ccc(F)cc1C(=O)NC1CCC(O)CC1,0.4642857142857143
Cn1c(=O)c(=O)n(CC(=O)N2CCC3(CC2)OCCO3)c2cccnc21,0.4642857142857143
Cc1cc(N2CC[C@H](C)[C@H](O)C2)nc(C)[nH+]1,0.4642857142857143
O=c1n(CCO)c2ccccc2n1CCO,0.4571428571428572
O=C(CCCO)Nc1ccc(F)cc1F,0.4571428571428572
CCn1c(CC2CC[NH2+]CC2)nn(CCO)c1=O,0.4571428571428572
C[C@H]1C(=O)N(c2ccc3c(c2)CCC3)CCN1C(=O)c1ccc(Cl)c(Cl)c1,0.4571428571428572
CS(=O)(=O)[C@H]1O[C@H]1c1ccc(Cl)cc1Cl,0.4571428571428572
COc1ccc(/C=C2/SC(=O)N(CC(=O)Nc3ccc(F)cc3)C2=O)cc1OC,0.4571428571428572
CCOC(=O)c1sc(NC(=O)c2ccc(-n3c(C)nc4ccccc4c3=O)cc2)cc1C,0.4571428571428572
O=Cc1ccc(OCc2ccn(-c3cccc(F)c3)n2)cc1,0.4571428571428572
Clc1ccccc1Cn1ccnc1,0.4571428571428572
COc1ccccc1Nc1nn(CN(C)OC)c(=S)s1,0.4571428571428572
CC[NH+]1CCN(C2(CNC(=O)c3ccccc3Br)CCCCC2)CC1,0.4571428571428572
CCc1nn(C)cc1CNC(=O)C1(CC)CCC1,0.4571428571428572
Cc1cc2nc(C)c(CCC(=O)NC[C@@H](c3ccccc3)N3CCOCC3)c(C)n2n1,0.4571428571428572
COc1ccc2c(c1)N(C(=O)CCSc1ccccn1)C[C@@H](C)O2,0.45
Cc1cc(C)c2nc(N3CCN(C(=O)[C@@H]4CCCCN4S(C)(=O)=O)CC3)sc2c1,0.45
Cc1cc(Cl)ccc1OCC(=O)N/N=C/c1ccccn1,0.45
C[C@H](CSc1ccc(C(=O)N(C)C)cn1)C(=O)[O-],0.45
O=C(C[C@@H]1C[NH2+]CCO1)N[C@H]1C=CS(=O)(=O)C1,0.45
CC(C)[NH+]1CCC(N2CC[NH+](Cc3c(F)ccc(F)c3F)C[C@@H]2CCO)CC1,0.45
Cc1ccc(C)c2nc3sc(C(=O)Nc4ccc5c(c4)OCO5)c(N)c3cc12,0.45
COCCN1[C@H](C)CN(C(=O)C[NH+](C)C2CC2)C[C@@H]1C,0.45
C/[NH+]=C(/NCc1noc(C(C)(C)C)n1)N[C@@H](C)c1ccc(F)cc1F,0.45
C[C@H]1CCCN(c2ccc(C(=O)Nc3ccc(N4CCOCC4)cc3)cc2[N+](=O)[O-])C1,0.4428571428571429
Cc1cc(N(C)C)ccc1NC(=O)c1ccc(CN2CC[NH+](C)CC2)cc1,0.4428571428571429
O=C(NCc1ccc([N+]2=CCCC2)cc1)NC1(c2ccc(Cl)cc2)CC1,0.4428571428571429
O=C(NCCNS(=O)(=O)c1cccc(Cl)c1F)c1cccnc1,0.4428571428571429
Cc1c(C(=O)N(C)[C@@H]2CCN(c3ccccc3Cl)C2=O)cnn1C,0.4428571428571429
C[C@@H](CCO)SCc1ccccc1OC(F)F,0.4428571428571429
O=C(C[NH+]1CCC(C(=O)c2ccc(Cl)cc2)CC1)NC[C@H]1COCCO1,0.4428571428571429
CC[n+]1c(N)n(CCOc2ccc(Cl)cc2Cl)c2ccccc21,0.4428571428571429
O=C(Nc1ccc(-c2nc3ccccc3o2)cc1)[C@H]1CCCN1S(=O)(=O)c1ccc(F)cc1,0.43571428571428567
CCC[NH2+]C1CCC(O)(Cc2nc(C)cs2)CC1,0.43571428571428567
Cc1nnsc1C(=O)Nc1nnc(-c2ccc(Br)cc2)o1,0.43571428571428567
CCCCn1nc(C)c(C[NH2+]C[C@@H](C)O)c1Cl,0.43571428571428567
c1cc(CN2CC[NH+](Cc3ccc4c(c3)OCCO4)CC2)no1,0.42857142857142855
Oc1ccc(C2[NH+](Cc3ccccc3)CC[NH+]2Cc2ccccc2)c(O)c1,0.42857142857142855
C[C@@H](Nc1ccc2c(c1)CCC2)C(=O)N1CCCC1,0.42857142857142855
Cc1nccn1CC(=O)N1CCCC[C@@H]1CCNC(=O)c1ccccc1,0.42857142857142855
Cc1noc(C)c1CCCNC(=O)N[C@H]1CC(=O)N(C2CC2)C1,0.42857142857142855
CN(C)c1ccc([C@H](CNC(=O)C(=O)Nc2ccccc2C#N)N2CC[NH+](C)CC2)cc1,0.42142857142857143
CCc1ncc(CN(C)C(=O)Nc2c(C)ccc([N+](=O)[O-])c2C)s1,0.42142857142857143
CC#CCC(=O)C1([NH+](CC)CC)CCCC1,0.42142857142857143
CC1(C)C(=O)NCC[NH+]1Cc1ccc(OCC(F)F)cc1,0.42142857142857143
O=S(=O)(/N=C(\[O-])c1ccsc1)N1CCCC1,0.42142857142857143
C/C(=C1/SC(=O)N(c2ccc(Cl)cc2)C1=O)c1ccc(Br)cc1,0.42142857142857143
COc1cc(C)c([C@@H](C)NC(=O)CSC2CCCC2)cc1OC,0.42142857142857143
CC(C)Oc1ccc(-c2nc(C(=O)O[C@@H](C)[C@@H]3CCOC3)cs2)cc1,0.42142857142857143
COCCCNC(=O)[C@H]1CN(C(=O)c2cccs2)CC12CCCCC2,0.42142857142857143
CCOc1ncnc(S(=O)(=O)CC)c1N,0.41428571428571426
CCOc1cccc(NC(=O)NCc2ccc(N3CCSCC3)cc2)c1,0.41428571428571426
C[C@@H](Nc1ccc(COC(C)(C)C)cc1)c1ccc(C#N)cc1,0.41428571428571426
CC(=O)Nc1ccc(O[C@H](C)c2nc(C(C)(C)C)no2)cc1,0.41428571428571426
O[C@H]1CCN(c2ccnc(N3CCc4[nH]c5ccc(Cl)cc5c4C3)n2)C1,0.41428571428571426
COc1ccc(N2C(=O)CS[C@H]2c2ccc(Cl)cc2)cc1Cl,0.41428571428571426
C=CCN(Cc1cccc([N+](=O)[O-])c1)C(=O)Nc1cc(OC)ccc1Cl,0.40714285714285714
CC(=O)N[C@@H](C(=O)NC1COC1)C(C)C,0.40714285714285714
C#CCN(C[C@H]1CCCO1)C(=O)N[C@@H](C)c1cccc([N+](=O)[O-])c1,0.40714285714285714
CCCS(=O)(=O)c1ccccc1C(=O)Nc1nnc(CC)s1,0.40714285714285714
CC(=O)c1ccc(S(=O)(=O)N2CCCC[C@H]2C)cc1,0.39999999999999997
O=C(NCCCc1nc(-c2ccc(Br)o2)no1)C1CC1,0.39999999999999997
CC[C@@H](C)[C@@H]([NH3+])c1ccc(Cl)s1,0.39999999999999997
CC(=O)N[C@H](C)C(=O)Nc1ccc(Sc2nncs2)c(Cl)c1,0.39999999999999997
COc1ccc(C(=O)OCc2nc3ccccc3s2)cn1,0.39999999999999997
CC[NH+](CC)[C@](C)(CC)[C@H](O)c1cscc1Br,0.39285714285714285
C[C@@H](Sc1nc(/C=C/c2cccs2)n[nH]1)C(=O)N1CCOCC1,0.39285714285714285
COCCCN1C(=O)c2ccc(C(=O)Nc3nc(-c4ccc(C)cc4)cs3)cc2C1=O,0.39285714285714285
ClC(Cl)(Cl)c1nonc1C(Cl)(Cl)Cl,0.39285714285714285
C[NH+](C)Cc1cc(NC(=O)CCCC(=O)N2CCCCCC2)[nH]n1,0.39285714285714285
COc1ccc(OC)c(/C=C2\Oc3cc(OC(=O)c4ccncc4)cc(C)c3C2=O)c1,0.38571428571428573
CCOC(=O)c1sc(/C=C/c2nc3c(s2)CCC3)nc1C,0.38571428571428573
CN(C)S(=O)(=O)c1ccc(C(=O)N(C(=O)N2CCCCC2)c2ccccc2)cc1,0.38571428571428573
C[C@@H]1[C@H](C(=O)[O-])CCN1S(=O)(=O)c1ccc(F)c(Cl)c1,0.38571428571428573
CC(C)[C@@H](C)CC(=O)NNC(=S)NC1CCCCC1,0.38571428571428573
Cc1ccc(C(F)(F)F)cc1/C=C/C(=O)[O-],0.38571428571428573
COCc1ccc(C(=O)N(C)Cc2ccc(Cl)s2)cc1,0.37857142857142856
O=C([C@H]1CCCN1S(=O)(=O)N1CCCCC1)N1CCSCC1,0.37857142857142856
CCCCCN1C(=O)/C(=C/c2ccc(O)c(OCC)c2)SC1=S,0.37857142857142856
CCc1cccc(CC)c1NC(=O)NC1CC1,0.37857142857142856
COCC[C@H](C)C(=O)N[C@@H](C)COC,0.37142857142857144
CC[C@H](C)C[C@@H](C)NC(=O)N1CCN(CC(=O)NC2CC2)CC1,0.36428571428571427
CC[C@@H](C)CNc1nc2ccc(Cl)cc2s1,0.36428571428571427
CCC(CC)[S@](=O)CCC(=O)[O-],0.35714285714285715
CCNC(=O)c1cccc(NC(=O)NCCCSC)c1,0.35000000000000003
CCc1noc(C)c1C[NH+](C[C@@H]1CCCCO1)C(C)C,0.34285714285714286
C=CCN(CC(=O)[O-])C(=O)[C@@H](C[NH3+])C(C)C,0.2785714285714286
CCO[C@H]1C(=O)O[C@H]([C@@H](O)CO)C1=O,0.0
CCOC(=O)[C@H](F)[C@@]1(O)CCC[NH+](C(C)C)CC1,0.0
Cc1cccc(COc2ccc(Br)cc2/C=C2\SC(=S)NC2=O)c1,0.0
c1ccc2c(c1)CC[C@H]([C@H]1CCCc3cccnc31)N2,0.0
Cc1cc(=O)[nH]c(SCC(=O)N2C[C@]3(C)C[C@H]2CC(C)(C)C3)n1,0.0
CC[S@](=O)[C@H]1CCCC[C@@H]1NC(=O)NC[C@H](O)c1ccco1,0.0