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0728617 | 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 | # sc-ImmuAging – Human PBMC Single Cell Aging Clock Dataset
This repository contains a summary of tables extracted from the supplementary materials of the publication:
> **"A single-cell immune clock of human aging"**
> *Science Advances, 2022*
> DOI: [10.1126/sciadv.abn5631](https://doi.org/10.1126/sciadv.abn5631)
The extracted tables are converted into a structured `.parquet` file for easier use in computational pipelines.
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## 📦 Dataset Description
| Table | Description |
|------------|-------------------------------------------------------------------------|
| Table S1 | Summary of scRNA-seq datasets used in this study (public + in-house) |
| Table S2 | Aging scores and model performance across models and cell types |
| Table S3 | Gene-level feature importance for predictive aging models |
These tables provide high-level information to replicate or interpret the immune aging clock models developed using single-cell RNA-seq data from human PBMCs.
---
## 🔧 Usage Instructions
### Load the Parquet File in Python
```python
import pandas as pd
df = pd.read_parquet("sciadv_abn5631_summary.parquet")
print(df)
```
---
## 💡 Use Cases
- Investigating immune cell aging patterns in human PBMCs
- Benchmarking single-cell predictive aging models
- Training or validating ML models using gene-level feature importance
- Augmenting multi-omics longevity studies
---
## 📚 Citation
If you use this dataset, please cite:
> Ma, L., et al. (2022). A single-cell immune clock of human aging. *Science Advances*, 8(46), eabn5631.
> DOI: [10.1126/sciadv.abn5631](https://doi.org/10.1126/sciadv.abn5631)
---
## 🙏 Acknowledgments
This dataset is derived from the supplementary materials of the original publication.
Data conversion and formatting by **Iris Lee** for use in longevity-related research and AI health hackathons. ### 🧑💻 Team: MultiModalMillenials. Iris Lee (`@iris8090`) |