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0	Diagnosis, Clinical Features, and Therapeutic Implications of Agitated Depression	Agitated "unipolar" depression is a clinical entity characterized by excitement together with depressed mood during the same episode. The clinical picture of agitated "unipolar" depression is characterized by a depressed and anxious mood with inner, psychic agitation, whereas motor agitation may or may not be present. ...	10.1016/j.psc.2019.10.011	121	Depression	우울증 질병의 이해
1	Clarifying the role of sleep in depression: A narrative review	It has been established that 4.4 to 20% of the general population suffers from a major depressive disorder (MDD), which is frequently associated with a dysregulation of normal sleep-wake mechanisms. Disturbances of circadian rhythms are a cardinal feature of psychiatric dysfunctions, including MDD, which tends to indic...	10.1016/j.psychres.2020.113239	269	Depression	우울증 질병의 이해
2	Psychotic Depression: Diagnosis, Differential Diagnosis, and Treatment	Psychotic depression was initially considered to be at one end of a continuum of severity of major depression. Subsequent experience demonstrated that psychosis is an independent trait that may accompany mood disorders of varying severity. While much has been learned about the impact of severe mood congruent delusions ...	10.1159/000511348	163	Depression	우울증 질병의 이해
3	Machine learning in the prediction of depression treatment outcomes: a systematic review and meta-analysis	Background: Multiple treatments are effective for major depressive disorder (MDD), but the outcomes of each treatment vary broadly among individuals. Accurate prediction of outcomes is needed to help select a treatment that is likely to work for a given person. We aim to examine the performance of machine learning meth...	10.1017/S0033291721003871	347	Depression	우울증 질병의 이해
4	[Clinical features of depression in adolescents with schizotypal disorder]	Objective: To study the clinical features of depressive disorders in adolescents with schizotypal disorder (STD). Material and methods: Were examined 87 adolescents with STD (F21), taken for outpatient or inpatient observation in 2018-2020. Of these, 26 patients were selected (12 males, 14 females, mean age 12.7±2.9 ye...	10.17116/jnevro202112105212	459	Depression	우울증 질병의 이해
5	The Italian version of the Depression Anxiety Stress Scales-21: Factor structure and psychometric properties on community and clinical samples	Objective: The Depression Anxiety Stress Scales-21 (DASS-21) is the short version of a self-report measure that was originally developed to provide maximum differentiation between depressive and anxious symptoms. Despite encouraging evidence, the factor structure and other features of the DASS-21 are yet to be firmly e...	10.1016/j.comppsych.2015.04.005	233	Depression	우울증 질병의 이해
6	Analysis of Automated Clinical Depression Diagnosis in a Chinese Corpus	Depression clinical interview corpora are essential for advancing automated depression diagnosis. While previous studies have used written speech material in controlled settings, these materials do not accurately represent spontaneous conversational speech. Additionally, self-reported measures of depression are subject...	10.1109/TBCAS.2023.3291554	241	Depression	우울증 질병의 이해
7	Pharmacological treatment for psychotic depression	Background: Evidence is limited regarding the most effective pharmacological treatment for psychotic depression: monotherapy with an antidepressant, monotherapy with an antipsychotic, another treatment (e.g. mifepristone), or combination of an antidepressant plus an antipsychotic. This is an update of a review first pu...	10.1002/14651858.CD004044.pub5	1,331	Depression	우울증 질병의 이해
8	A Machine Learning Analysis of Big Metabolomics Data for Classifying Depression: Model Development and Validation	Background: Many metabolomics studies of depression have been performed, but these have been limited by their scale. A comprehensive in silico analysis of global metabolite levels in large populations could provide robust insights into the pathological mechanisms underlying depression and candidate clinical biomarkers....	10.1016/j.biopsych.2023.12.015	345	Depression	우울증 질병의 이해
9	Post-Psychotic Depression: An Updated Review of the Term and Clinical Implications	Background: Post-psychotic depression (PPD) is an important and frequent clinical phenomenon featuring controversial complexity in its nosological and aetiopathogenic cataloguing. Objectives: The main objective of this research was to review the published literature on PPD. The second objective was to indicate its clin...	10.1159/000520985	420	Depression	우울증 질병의 이해
10	Comparison on the clinical features in patients with or without treatment-resistant depression: A National Survey on Symptomatology of Depression report	Patients with treatment-resistant depression (TRD) have fewer treatment options and worse prognoses than those without TRD. Although the etiology or pathophysiology of TRD remains unclear, certain clinical variables have been found to be related to its severity and prognosis. Therefore, 1151 patients with recurrent dep...	10.1016/j.psychres.2022.114972	254	Depression	우울증 질병의 이해
11	Cingulate dynamics track depression recovery with deep brain stimulation	Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) can provide long-term symptom relief for treatment-resistant depression (TRD) 1 . However, achieving stable recovery is unpredictable 2 , typically requiring trial-and-error stimulation adjustments due to individual recovery trajectories and subjective sym...	10.1038/s41586-023-06541-3	294	Depression	우울증 질병의 이해
12	Hyperthyroidism and depression: a clinical case of atypical thyrotoxicosis manifestation	The relationship between psychiatric symptoms and thyroid function has been well known and studied since antiquity. The common view is that clinical hypothyroidism is associated with depressive symptoms, whereas the psychiatric manifestations of hyperthyroidism are agitation, emotional lability, hyperexcitability, occa...	10.1097/YIC.0000000000000438	224	Depression	우울증 질병의 이해
13	[Clinical features of depressive episode with onset in adolescence and the risk of bipolar depression]	Aim: To study clinical features of depressive episode with the onset in late adolescence associated with the risk of bipolar affective disorder (BAD). Material and methods: Forty patients with BAD (ICD-10 F31), who experienced depressive state at the age of 15-18 years corresponding to the diagnostic criteria of 'Depre...	10.17116/jnevro20191191222	293	Depression	우울증 질병의 이해
14	Ketamine Treatment in Depression: A Systematic Review of Clinical Characteristics Predicting Symptom Improvement	Ketamine has been shown to be efficacious for the treatment of depression, specifically among individuals who do not respond to first-line treatments. There is still, however, a lack of clarity surrounding the clinical features and response periods across samples that respond to ketamine. This paper systematically revi...	10.2174/1568026620666200423094423	211	Depression	우울증 질병의 이해
15	Comparison of Functional and Structural Neural Network Features in Older Adults With Depression With vs Without Apathy and Association With Response to Escitalopram: Secondary Analysis of a Nonrandomized Clinical Trial	Importance: Apathy is prevalent among individuals with late-life depression and is associated with poor response to pharmacotherapy, including chronicity and disability. Elucidating brain networks associated with apathy and poor treatment outcomes can inform intervention development. Objectives: To assess the brain net...	10.1001/jamanetworkopen.2022.24142	772	Depression	우울증 질병의 이해
16	Clinical features of depression in Asia: results of a large prospective, cross-sectional study	Introduction: The objective of this study was to investigate the clinical features of depression in Asian patients. Methods: It was a cross-sectional, observational study of depression in China, Korea, Malaysia, Singapore, Taiwan, and Thailand. Participants were drug-free outpatients with depressed mood and/or anhedoni...	10.1111/appy.12104	443	Depression	우울증 질병의 이해
17	A Study of Individualized Diagnosis and Treatment for Depression with Atypical Features (iDoT-AFD): study protocol for a randomized clinical trial and prognosis study	Background: Major depressive disorder (MDD) with atypical features, namely depression with atypical features (AFD), is one of the most common clinical specifiers of MDD, closely associated with bipolar disorder (BD). However, there is still a lack of clinical guidelines for the diagnosis, treatment, and prognosis of AF...	10.1186/s13063-023-07317-w	499	Depression	우울증 질병의 이해
18	Clinical features of emergency department patients with depression who had attempted to commit suicide by poisoning	Background: Many patients present to the emergency department (ED) complaining of intentional poisoning. Of those, some have major depressive disorder (MDD) in their medical history. The aim of this study was to investigate the prevalence of MDD patients who were treated for poisoning in the ED. Materials and methods: ...	10.4103/1119-3077.164329	340	Depression	우울증 질병의 이해
19	Effects of Lactobacillus plantarum PS128 on Depressive Symptoms and Sleep Quality in Self-Reported Insomniacs: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial	Recent animal studies have supported that Lactobacillus plantarum PS128 (PS128) can reduce the severity of anxiety and depression. However, previous studies did not focus on the sleep quality and mood of humans. This study determines whether PS128 reduces the severity of anxiety and depressive symptoms, regulates auton...	10.3390/nu13082820	310	Depression	우울증 질병의 이해
20	Response of depression to electroconvulsive therapy: a meta-analysis of clinical predictors	Objective: Roughly one-third of individuals with depression do not respond to electroconvulsive therapy (ECT). Reliable predictors of ECT response would be useful for patient selection, but have not been demonstrated definitively. We used meta-analysis to measure effect sizes for a series of clinical predictors of ECT ...	10.4088/JCP.14r09528	427	Depression	우울증 질병의 이해
21	[Clinical and psychopatological features of endogenous depressions in young women]	Objective: To study the features of psychopatological structure of endogenous depression in young women and to identify correlations between various clinical types of depression and their nosological affilation. Material and methods: The results of clinical/psychopathological examination of 107 female patients, aged 16...	10.17116/jnevro202112105227	445	Depression	우울증 질병의 이해
22	The genealogy of major depression: symptoms and signs of melancholia from 1880 to 1900	How deep are the historical roots of our concept of major depression (MD)? I showed previously that psychiatric textbooks published in 1900-1960 commonly described 18 characteristic depressive symptoms/signs that substantially but incompletely overlapped with the current DSM (Diagnostic and Statistical Manual of Mental...	10.1038/mp.2017.148	373	Depression	우울증 질병의 이해
23	Factor analyses differentiate clinical phenotypes of idiopathic and interferon-alpha-induced depression	The discovery that prolonged administration of interferon-alpha (a pro-inflammatory cytokine) readily precipitates depressive symptoms has played a key role in development of the inflammation theory of major depressive disorder (MDD). However, it remains unclear whether the clinical phenotype of patients with inflammat...	10.1016/j.bbi.2019.04.035	407	Depression	우울증 질병의 이해
24	CLINICAL, GENEALOGICAL AND PATHOPSYCHOLOGICAL RISK MARKERS OF RECURRENT DEPRESSION	The goal was to determine clinical and genealogical and pathophysiological markers of the risk recurrent depression development risk. Clinical and psychopathological, genealogical, psychometric (Montgomery-Asberg Depression Rating Scale - MADRS), "Psychological Autobiography" method (Burlachuk L.F., Korzhova E.Yu., 199...	null	500	Depression	우울증 질병의 이해
25	Clinical and course characteristics of depression and all-cause mortality: A prospective population-based study	Background: Given the large heterogeneity of depressive disorders (DD), studying depression characteristics according to clinical manifestations and course is a more promising approach than studying depression as a whole. The purpose of this study was to determine the association between clinical and course characteris...	10.1016/j.jad.2015.09.010	381	Depression	우울증 질병의 이해
26	Mixed Features in Depression: The Unmet Needs of Diagnostic and Statistical Manual of Mental Disorders Fifth Edition	The Diagnostic and Statistical Manual of Mental Disorders Fifth Edition introduced the specifier "with mixed features" including 3 or more nonoverlapping typical manic symptoms during a major depressive episode in bipolar disorder type I or II or unipolar major depressive disorder. Excluding overlapping excitatory symp...	10.1016/j.psc.2019.10.006	138	Depression	우울증 질병의 이해
27	Distinguishing burnout from clinical depression: A theoretical differentiation template	Background: Burnout and clinical depression have been variably viewed as synonymous or as distinctly differing entities - but with few distinguishing features provided. Failure to differentiate the two conditions can lead to compromised clinical management. We sought to enhance the differentiation of burnout and clinic...	10.1016/j.jad.2020.12.022	272	Depression	우울증 질병의 이해
28	Investigation of early and lifetime clinical features and comorbidities for the risk of developing treatment-resistant depression in a 13-year nationwide cohort study	Background: To investigate the risk of treatment-resistant depression (TRD) in patients with depression by examining their clinical features, early prescription patterns, and early and lifetime comorbidities. Methods: In total, 31,422 depressive inpatients were followed-up from diagnostic onset for more than 10-years. ...	10.1186/s12888-020-02935-z	349	Depression	우울증 질병의 이해
29	Detecting subtle signs of depression with automated speech analysis in a non-clinical sample	Background: Automated speech analysis has gained increasing attention to help diagnosing depression. Most previous studies, however, focused on comparing speech in patients with major depressive disorder to that in healthy volunteers. An alternative may be to associate speech with depressive symptoms in a non-clinical ...	10.1186/s12888-022-04475-0	446	Depression	우울증 질병의 이해
30	The use of antidepressants in bipolar disorder patients with depression	Introduction: The proportion of time that bipolar patients experience depressive symptoms and clinical states, with associated psychosocial impairment and elevated risk of suicide, is significantly greater than the time spent in manic/hypomanic forms of bipolar disorders. Yet, manic states and symptoms have been the fo...	10.1517/14656566.2016.1104299	288	Depression	우울증 질병의 이해
31	Structural and functional features of treatment-resistant depression: A systematic review and exploratory coordinate-based meta-analysis of neuroimaging studies	Objectives: A third of people suffering from major depressive disorder do not experience a significant improvement in their symptoms even after adequate treatment with two different antidepressant medications. This common condition, termed treatment-resistant depression (TRD), severely affects the quality of life of mi...	10.1111/pcn.13530	363	Depression	우울증 질병의 이해
32	Incidence of melancholic depression by age of onset and gender in the Lundby population, 1947-1997	Whether melancholic depression is a distinct syndrome or not has long been debated. There are few studies providing information about the epidemiology of melancholic depression. In this study, we investigate the incidence rates, overall as well as by gender and age of onset of melancholic depression according to Taylor...	10.1007/s00406-022-01506-5	359	Depression	우울증 질병의 이해
33	[Clinical characteristics of depression in patients with episodic consumption of and dependence on alcohol]	Aim: To study clinical and psychopathological features of depression in patients with consumption of and dependence on alcohol. Material and methods: Eighty-nine depressed patients were examined. The first group included patients with depressive disorders complicated by alcoholism. The second group included patients, w...	10.17116/jnevro20171173111-15	229	Depression	우울증 질병의 이해
34	Treatment-resistant depression with anhedonia: Integrating clinical and preclinical approaches to investigate distinct phenotypes	In our clinical work with treatment-resistant depressed (TRD) patients, certain patterns have emerged in terms of patients' presentations of anhedonia. Multiple studies have investigated anhedonia either as a state or a trait variable in depression, but anhedonia is a multifaceted construct and, as we better understand...	10.1016/j.neubiorev.2022.104578	221	Depression	우울증 질병의 이해
35	Bilateral Habenula deep brain stimulation for treatment-resistant depression: clinical findings and electrophysiological features	Deep brain stimulation (DBS) of structures in the brain's reward system is a promising therapeutic option for patients with treatment-resistant depression (TRD). Recently, DBS of the habenula (HB) in the brain's anti-reward system has also been reported to alleviate depressive symptoms in patients with TRD or bipolar d...	10.1038/s41398-022-01818-z	415	Depression	우울증 질병의 이해
36	Clinical Characteristics of Melancholic and Nonmelancholic Depressions	This study aimed to compare clinical-demographic features of melancholic and nonmelancholic depressions. We included 141 depressed inpatients classified as melancholic and nonmelancholic by the Sydney Melancholia Prototype Index (SMPI) and Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) crite...	10.1097/NMD.0000000000001616	223	Depression	우울증 질병의 이해
37	Multilingual markers of depression in remotely collected speech samples: A preliminary analysis	Background: Speech contains neuromuscular, physiological and cognitive components, and so is a potential biomarker of mental disorders. Previous studies indicate that speaking rate and pausing are associated with major depressive disorder (MDD). However, results are inconclusive as many studies are small and underpower...	10.1016/j.jad.2023.08.097	340	Depression	우울증 질병의 이해
38	A Novel Mouse Model of Depression: Advantages in Immune Research and Clinical Translation	The role of neuroimmune mechanisms in major depressive disorder (MDD) has been gradually highlighted, but existing classical animal models of MDD have limitations in immune inflammation research due to physical injury, high mortality rates, and immune tolerance. This study developed a novel mouse model of depression ca...	10.7150/ijbs.104950	266	Depression	우울증 질병의 이해
39	Biased cognitive control of emotional information in remitted depression: A meta-analytic review	Cognitive theories of depression posit that maladaptive information processing increases the risk for depression recurrence. There is increasing theoretical and empirical support for the cognitive control of emotional information as a vulnerability factor for depression recurrence. In this investigation, findings from ...	10.1037/abn0000848	279	Depression	우울증 질병의 이해
40	Prediction of depression treatment outcome from multimodal data: a CAN-BIND-1 report	Background: Prediction of treatment outcomes is a key step in improving the treatment of major depressive disorder (MDD). The Canadian Biomarker Integration Network in Depression (CAN-BIND) aims to predict antidepressant treatment outcomes through analyses of clinical assessment, neuroimaging, and blood biomarkers. Met...	10.1017/S0033291722002124	362	Depression	우울증 질병의 이해
41	Epidemiology of depression in India	Depressive disorders constitute one of the major mental health problems. The cross and intracultural differences in etiology, clinical features and course and outcome vary maximally in depressives than in any other mental illness, and epidemiological studies have been a major strategy to delineate the same. In this rep...	10.1159/000285129	97	Depression	우울증 질병의 이해
42	Prediction of anxious depression using multimodal neuroimaging and machine learning	Anxious depression is a common subtype of major depressive disorder (MDD) associated with adverse outcomes and severely impaired social function. It is important to clarify the underlying neurobiology of anxious depression to refine the diagnosis and stratify patients for therapy. Here we explored associations between ...	10.1016/j.neuroimage.2023.120499	410	Depression	우울증 질병의 이해
43	AUTISM AND DEPRESSION (REVIEW)	The present paper aims to summarize and review available research on the manifestations of comorbid depression in persons with ASD (Autism spectrum Disorder) and its impact on the course of autism;as well as to review the pharmacological treatment of comorbid depression with ASD. The existence of a comorbid depression ...	null	224	Depression	우울증 질병의 이해
44	Subthreshold depression in adolescence: Gender differences in prevalence, clinical features, and associated factors	Background: Subthreshold depression (SD) is an important mental health problem in adolescence given its high prevalence, comorbidity, and functional impairment. However, currently little is known about gender differences of SD in adolescence. The aim of this study was to examine gender differences in prevalence, clinic...	10.1016/j.jad.2020.03.111	379	Depression	우울증 질병의 이해
45	Animal models of depression: navigating through the clinical fog	Animal models of human disease have proven of considerable value in elucidating basic pathophysiological mechanisms and in developing novel treatments. However, modelling human mental disorders in experimental animals is fraught with difficulties. Depression models generally lack both clinical and scientific credibilit...	10.1016/j.neubiorev.2005.03.005	223	Depression	우울증 질병의 이해
46	Discriminating subclinical depression from major depression using multi-scale brain functional features: A radiomics analysis	Background: The diagnosis of subclinical depression (SD) currently relies exclusively on subjective clinical scores and structured interviews, which shares great similarities with major depression (MD) and increases the risk of misdiagnosis of SD and MD. This study aimed to develop a method of disease classification fo...	10.1016/j.jad.2021.10.122	355	Depression	우울증 질병의 이해
47	Critical analysis of the impact of glottal features in the classification of clinical depression in speech	The motivation for this work is in an attempt to rectify the current lack of objective tools for clinical analysis of emotional disorders. This study involves the examination of a large breadth of objectively measurable features for use in discriminating depressed speech. Analysis is based on features related to prosod...	10.1109/TBME.2007.900562	178	Depression	우울증 질병의 이해
48	Evaluating the role of orexins in the pathophysiology and treatment of depression: A comprehensive review	Orexins are neuropeptides that are postulated to play a central role in the regulation of the sleep-wake cycle, appetite, affect, and reward circuitry. The objectives of the current review are to comprehensively evaluate (1) the potential role of orexins in the pathophysiology of major depressive disorders (MDD) and (2...	10.1016/j.pnpbp.2018.12.008	311	Depression	우울증 질병의 이해
49	Data-driven biological subtypes of depression: systematic review of biological approaches to depression subtyping	Research into major depressive disorder (MDD) is complicated by population heterogeneity, which has motivated the search for more homogeneous subtypes through data-driven computational methods to identify patterns in data. In addition, data on biological differences could play an important role in identifying clinicall...	10.1038/s41380-019-0385-5	388	Depression	우울증 질병의 이해
50	Gender differences in clinical features of depressed outpatients: preliminary evidence for subtyping of depression?	Background: Gender differences in depression are usually associated with prevalence, severity, and sometimes with specific syndromes or subtypes. However, a lack of differentiation exists between these factors. Aims: To disentangle depression severity and the specific items endorsed by men and women and thus explore th...	10.1300/j013v46n04_02	414	Depression	우울증 질병의 이해
51	Associated symptoms of depression: patterns of change during pregnancy	Little is known about the natural course of depressive symptoms and associated features throughout pregnancy. We examined the course of some psychological and somatic symptoms in each month of pregnancy in a normative sample. A consecutive, unselected sample of women (N = 374) were interviewed retrospectively at 6 week...	10.1007/s00737-016-0685-6	426	Depression	우울증 질병의 이해
52	Psychometric properties of the PHQ-9 depression scale in people with multiple sclerosis: A systematic review	Background: Depression affects approximately 25% of people with MS (pwMS) at any given time. It is however under recognised in clinical practice, in part due to a lack of uptake for brief assessment tools and uncertainty about their psychometric properties. The 9-item Patient Health Questionnaire (PHQ-9) is an attracti...	10.1371/journal.pone.0197943	468	Depression	우울증 질병의 이해
53	Effect of severity of depression on augmentation of antidepressant medication in young adults with depression	Background: Antipsychotics (AP) have been used to augment antidepressant (AD) medication in treatment-resistant depression. In this study we examined factors (including severity of depression and initial antidepressant) affecting AP augmentation, as well as which APs were initiated as augmentation in young adults. Meth...	10.1111/acps.13633	442	Depression	우울증 질병의 이해
54	Epilepsy coexisting with depression	Depression episodes in epilepsy is the most common commorbidity, affecting between 11% and 62% of patients with epilepsy. Although researchers have documented a strong association between epilepsy and psychiatric comorbidities, the nature of this relationship is poorly understood. The manifestation of depression in epi...	10.1016/j.pharep.2016.06.011	276	Depression	우울증 질병의 이해
55	Prevalence and clinical features of atypical depression in depressed outpatients: a 467-case study	The prevalence of DSM-IV atypical depression and differences between atypical versus non-atypical depression were investigated in 467 unipolar and bipolar depressed outpatients in private practice. Consecutive outpatients presenting for treatment of a major depressive episode were assessed with the Comprehensive Assess...	10.1016/s0165-1781(99)00035-9	218	Depression	우울증 질병의 이해
56	Clinical features of situational and nonsituational major depression	Clinical lore has long supported the subtype of situational or reactive depression. To date, however, there has been limited empirical research support for this subtype of major depression. We examined demographic, clinical and personality features of situational and nonsituational depression in 89 outpatients with uni...	10.1159/000284813	112	Depression	우울증 질병의 이해
57	Speech Features as Predictors of Momentary Depression Severity in Patients With Depressive Disorder Undergoing Sleep Deprivation Therapy: Ambulatory Assessment Pilot Study	Background: The use of mobile devices to continuously monitor objectively extracted parameters of depressive symptomatology is seen as an important step in the understanding and prevention of upcoming depressive episodes. Speech features such as pitch variability, speech pauses, and speech rate are promising indicators...	10.2196/49222	553	Depression	우울증 질병의 이해
58	EEG-based deep learning model for the automatic detection of clinical depression	Clinical depression is a neurological disorder that can be identified by analyzing the Electroencephalography (EEG) signals. However, the major drawback in using EEG to accurately identify depression is the complexity and variation that exist in the EEG of a depressed individual. There are several strategies for automa...	10.1007/s13246-020-00938-4	252	Depression	우울증 질병의 이해
59	A study on classification features of depressive symptoms in adolescents	Although extensive literature has addressed depression among adolescents, few studies have emphasized the classification features of depressive symptoms in adolescents. To gain insight into the hierarchy and heterogeneity of depression in adolescents based on symptoms, 5086 adolescents completed the Chinese version of ...	10.1080/09638237.2019.1677865	266	Depression	우울증 질병의 이해
60	The specific phenotype of depression in recent onset schizophrenia spectrum disorders: A symptom profile and network comparison to recent onset major depressive disorder without psychotic features	The specific phenotype of depression in recent-onset schizophrenia spectrum disorders (SSD) and its relation to non-psychotic depression is unknown. Symptom profile and network analysis are complementary statistical techniques that may provide important insights into the presentation and relative importance of individu...	10.1016/j.schres.2021.11.048	300	Depression	우울증 질병의 이해
61	Early antidepressant treatment response prediction in major depression using clinical and TPH2 DNA methylation features based on machine learning approaches	Objective: To identify DNA methylation and clinical features, and to construct machine learning classifiers to assign the patients with major depressive disorder (MDD) into responders and non-responders after a 2-week treatment into responders and non-responders. Method: Han Chinese patients (291 in total) with MDD com...	10.1186/s12888-023-04791-z	445	Depression	우울증 질병의 이해
62	Discriminating melancholic and non-melancholic depression by prototypic clinical features	Background: Melancholia is positioned as either a more severe expression of clinical depression or as a separate entity. Support for the latter view emerges from differential causal factors and treatment responsiveness but has not been convincingly demonstrated in terms of differential clinical features. We pursue its ...	10.1016/j.jad.2012.06.042	698	Depression	우울증 질병의 이해
63	Atypical depression among psychiatric inpatients: clinical features and personality traits	Objective: This study investigates the frequency and characteristics of Atypical Depression (AD) among depressed inpatients. Method: Twenty-one depressed inpatients received DSM-IV diagnoses, were rated on the Hamilton Depression Rating Scale (HAMD), and assessed for AD using the Atypical Depressive Disorder Scale. AD ...	10.1016/0165-0327(96)00022-5	300	Depression	우울증 질병의 이해
64	Diagnosis of peripartum depression disorder: A state-of-the-art approach from the COST Action Riseup-PPD	Background: Peripartum depression (PPD) is a major depression disorder (MDD) episode with onset during pregnancy or within four weeks after childbirth, as defined in DSM-5. However, research suggests that PPD may be a distinct diagnosis. The goal of this study was to summarize the similarities and differences between P...	10.1016/j.comppsych.2024.152456	359	Depression	우울증 질병의 이해
65	Are symptom features of depression during pregnancy, the postpartum period and outside the peripartum period distinct? Results from a nationally representative sample using item response theory (IRT)	Background: Whether there are systematic differences in depression symptom expression during pregnancy, the postpartum period and outside these periods (i.e., outside the peripartum period) remains debated. The aim of this study was to use methods based on item response theory (IRT) to examine, after equating for depre...	10.1002/da.22334	349	Depression	우울증 질병의 이해
66	Neuroimmune nexus of depression and dementia: Shared mechanisms and therapeutic targets	Dysfunctional immune activity is a physiological component of both Alzheimer's disease (AD) and major depressive disorder (MDD). The extent to which altered immune activity influences the development of their respective cognitive symptoms and neuropathologies remains under investigation. It is evident, however, that im...	10.1111/bph.14569	277	Depression	우울증 질병의 이해
67	A single case series of imagery rescripting of intrusive autobiographical memories in depression	Background and objectives: Intrusive memories are a common feature of depression, thought to be related to the onset and maintenance of the disorder. Intrusive memories have been successfully targeted in posttraumatic stress disorder through imagery rescripting. Yet there is limited evidence for the effectiveness of th...	10.1016/j.jbtep.2023.101854	282	Depression	우울증 질병의 이해
68	Psychomotor retardation in depression: A critical measure of the forced swim test	DSM-5 lists 9 different symptoms for major depressive disorder and dictates that either "depressed mood" or "loss of interest or pleasure" should be present for diagnosis. Both are relatively high-level symptoms of the complex affecto-cognitive disease. However, the single most common behavioral paradigm and the gold s...	10.1016/j.bbr.2019.112047	286	Depression	우울증 질병의 이해
69	Well-being therapy in depression: New insights into the role of psychological well-being in the clinical process	A specific psychotherapeutic strategy for increasing psychological well-being and resilience, well-being therapy (WBT), has been developed and validated in a number of randomized controlled trials. The findings indicate that flourishing and resilience can be promoted by specific interventions leading to a positive eval...	10.1002/da.22629	284	Depression	우울증 질병의 이해
70	Apathy in Neurodegenerative Diseases: Recommendations on the Design of Clinical Trials	Apathy is a common feature of neurodegenerative disorders but is difficult to study in a clinical trial setting due to practical and conceptual barriers. Principal challenges include a paucity of data regarding apathy in these disorders, an absence of established diagnostic criteria, the presence of confounding factors...	10.1177/0891988715573534	211	Depression	우울증 질병의 이해
71	Role of depression in heart failure--choosing the right antidepressive treatment	Major depression is a common feature of heart failure patients and possibly stems from their common biochemical background. Depression and heart failure co-morbidity has several clinical implications on the prognosis of these patients. Furthermore antidepressive drugs have known cardiovascular side effects, while their...	10.1016/j.ijcard.2009.05.022	189	Depression	우울증 질병의 이해
72	Cultural differences in the development and characteristics of depression	Depression is a highly prevalent mental illness with increasing burden for the patients, their families and society as well. In spite of its increasing importance, we still do not have complete understanding either of the phenomenology or the etiopathological background of depression, and cross-country, cross-ethnic an...	null	152	Depression	우울증 질병의 이해
73	Changes of cortical thickness in the first episode, drug-naive depression patients with and without melancholic features	Melancholic depression (MD) is a more severe type of major depressive disorder (MDD) with a core feature of anhedonia. However, its pathophysiology remains unclear. The current study aims to investigate whether there is a significant difference in cortical thickness (CT) that can be used to differentiate MD patients fr...	10.1016/j.pscychresns.2023.111683	271	Depression	우울증 질병의 이해
74	Predicting Depression Onset in Young People Based on Clinical, Cognitive, Environmental, and Neurobiological Data	Background: Adolescent onset of depression is associated with long-lasting negative consequences. Identifying adolescents at risk for developing depression would enable the monitoring of risk factors and the development of early intervention strategies. Using machine learning to combine several risk factors from multip...	10.1016/j.bpsc.2021.03.005	380	Depression	우울증 질병의 이해
75	Sociodemographic and clinical features of patients with depressive disorder in Khartoum, Sudan	Background: It's known worldwide that depression is becoming a major health problem and its prevalence is increasing. The main objective of this study is to find out the prevalence of depression among patients attending a general psychiatric clinic, and study their sociodemographic and clinical features. Methods: Files...	null	318	Depression	우울증 질병의 이해
76	Noise Robust Recognition of Depression Status and Treatment Response from Speech via Unsupervised Feature Aggregation	In the presented work, we utilise a noisy dataset of clinical interviews with depression patients conducted over the telephone for the purpose of depression classification and automated detection of treatment response. Compared to most previous studies dealing with depression recognition from speech, our data set does ...	10.1109/EMBC40787.2023.10340985	190	Depression	우울증 질병의 이해
77	The impact of depression on the outcome of addictions treatment	The objectives of this study were to examine the prevalence and presentation of depression among patients with substance use disorders, and to explore the relationship between depression and the outcome of addictions treatment. Seventy-five patients were consecutively recruited upon entering addictions treatment, and w...	10.1016/s0740-5472(97)00183-9	211	Depression	우울증 질병의 이해
78	Depression and anxiety have distinct and overlapping language patterns: Results from a clinical interview	Depression has been associated with heightened first-person singular pronoun use ( I-usage ; e.g., "I," "my") and negative emotion words. However, past research has relied on nonclinical samples and nonspecific depression measures, raising the question of whether these features are unique to depression vis-à-vis freque...	10.1037/abn0000850	344	Depression	우울증 질병의 이해
79	A smartphone- and wearable-based biomarker for the estimation of unipolar depression severity	Drug development for mood disorders can greatly benefit from the development of robust, reliable, and objective biomarkers. The incorporation of smartphones and wearable devices in clinical trials provide a unique opportunity to monitor behavior in a non-invasive manner. The objective of this study is to identify the c...	10.1038/s41598-023-46075-2	348	Depression	우울증 질병의 이해
80	Prediction of electroconvulsive therapy response and remission in late-life depression: a review	Electroconvulsive therapy is an effective and well-tolerated antidepressant treatment for the elderly population. The place of electroconvulsive therapy in the treatment sequence for depression in the elderly is currently not well established. This review aims to identify the factors that contribute to a positive respo...	10.57187/s.3684	342	Depression	우울증 질병의 이해
81	Depression with atypical features in a sample of primary care outpatients: prevalence, specific characteristics and consequences	Background: In the context of the current debate on the clinical relevance of atypical depression, the present study investigated the prevalence and specific characteristics of the disorder in depressed primary care outpatients and compared patients with atypical and with the prototypical form of depression ("non-atypi...	10.1016/j.jad.2004.07.003	302	Depression	우울증 질병의 이해
82	Changes of anhedonia and cognitive symptoms in first episode of depression and recurrent depression, an analysis of data from NSSD	Background: Anhedonia and cognitive impairment are core features of major depressive disorder (MDD), and are essential to the treatment and prognosis. Here, we aimed to investigate anhedonia and its cognitive correlates between first episode of depression (FED) and recurrent depression (RD), which was part of the Natio...	10.1016/j.jad.2022.10.015	358	Depression	우울증 질병의 이해
83	Which mixed depression model? A comparison between DSM-5-defined mixed features and Koukopoulos' criteria	Background: The criteria of the Diagnostic and Statistical Manual of Mental Disorders 5th edition "with mixed features specifier" (DSM-5 MFS) are considered controversial since they include only typical manic symptoms. By contrast, Koukopoulos developed an alternative model of mixed depression (MxD) focusing primarily ...	10.1111/bdi.13166	440	Depression	우울증 질병의 이해
84	Age or age of onset: which is the best criterion to classify late-life depression?	In late-life depression (LLD), several differences between patients whose first episode is reported after age 65 (late-onset depression, LOD) and those with early-onset depression (EOD) might reflect the effects of brain ageing. To test this hypothesis, we analysed the impact of current age and age at illness onset on ...	10.1097/YIC.0000000000000472	428	Depression	우울증 질병의 이해
85	[Depression and schizophrenia]	Affective disorders in schizophrenia overlap with positive symptoms and are co-morbid with negative changes. At schizophrenia onset, depression may emerge in the form of psychogenic disorders (posttraumatic stress disorder, juvenile asthenic failure, etc.). Depression, developing during the disease, determines clinical...	null	162	Depression	우울증 질병의 이해
86	An empirical analysis of structural neuroimaging profiles in a staging model of depression	We examine structural brain characteristics across three diagnostic categories: at risk for serious mental illness; first-presenting episode and recurrent major depressive disorder (MDD). We investigate whether the three diagnostic groups display a stepwise pattern of brain changes in the cortico-limbic regions. Integr...	10.1016/j.jad.2024.01.246	333	Depression	우울증 질병의 이해
87	Differences in cognitive functions of atypical and non-atypical depression based on propensity score matching	Background: Clinical and etiological heterogeneity have hindered our understanding of depression, thus driving the studies of major depressive disorder (MDD) subtypes. Atypical depression (AD) is a subtype of MDD with atypical features. Cognitive impairment is one of the factors that contribute to the suffering of pati...	10.1016/j.jad.2023.01.071	352	Depression	우울증 질병의 이해
88	Emission of 22 kHz vocalizations in rats as an evolutionary equivalent of human crying: Relationship to depression	There is no clear relationship between crying and depression based on human neuropsychiatric observations. This situation originates from lack of suitable animal models of human crying. In the present article, an attempt will be made to answer the question whether emission of rat aversive vocalizations (22 kHz calls) m...	10.1016/j.bbr.2019.01.033	250	Depression	우울증 질병의 이해
89	The high prevalence of "soft" bipolar (II) features in atypical depression	Seventy-two percent of 86 major depressive patients with atypical features as defined by the DSM-IV and evaluated systematically were found to meet our criteria for bipolar II and related "soft" bipolar disorders; nearly 60% had antecedent cyclothymic or hyperthymic temperaments. The family history for bipolar disorder...	10.1016/s0010-440x(98)90080-3	309	Depression	우울증 질병의 이해
90	Ketamine for psychotic depression: An overview of the glutamatergic system and ketamine's mechanisms associated with antidepressant and psychotomimetic effects	Approximately 0.35-1% of the general population is afflicted with psychotic depression at some time in their life. Psychotic depression is a subtype of major depressive disorder characterized by mood congruent hallucinations and/or delusions. Patients with psychotic depression often represent the most severe cases, wit...	10.1016/j.psychres.2021.114231	300	Depression	우울증 질병의 이해
91	The Neurobiology of Motivational Deficits in Depression--An Update on Candidate Pathomechanisms	Anhedonia has long been recognized as a central feature of major depression, yet its neurobiological underpinnings remain poorly understood. While clinical definitions of anhedonia have historically emphasized reductions in pleasure and positive emotionality, there has been growing evidence that motivation may be subst...	10.1007/7854_2015_400	143	Depression	우울증 질병의 이해
92	The role of temperament and character in the anxiety-depression spectrum among Korean adults	Background: Temperament and character are useful in risk assessment and therapy of individuals in the anxiety-depression spectrum but understudied in South Korea. Objective: The study aimed to identify the temperament and character features associated with anxiety and/or depression in individuals with clinical disorder...	10.1016/j.jad.2024.05.052	377	Depression	우울증 질병의 이해
93	Machine learning based approaches for clinical and non-clinical depression recognition and depression relapse prediction using audiovisual and EEG modalities: A comprehensive review	Mental disorders are rapidly increasing each year and have become a major challenge affecting the social and financial well-being of individuals. There is a need for phenotypic characterization of psychiatric disorders with biomarkers to provide a rich signature for Major Depressive Disorder, improving the understandin...	10.1016/j.compbiomed.2023.106741	220	Depression	우울증 질병의 이해
94	Structuro-functional surrogates of response to subcallosal cingulate deep brain stimulation for depression	Subcallosal cingulate deep brain stimulation produces long-term clinical improvement in approximately half of patients with severe treatment-resistant depression. We hypothesized that both structural and functional brain attributes may be important in determining responsiveness to this therapy. In a treatment-resistant...	10.1093/brain/awab284	548	Depression	우울증 질병의 이해
95	Genetic heterogeneity and subtypes of major depression	Major depression (MD) is a heterogeneous disorder; however, the extent to which genetic factors distinguish MD patient subgroups (genetic heterogeneity) remains uncertain. This study sought evidence for genetic heterogeneity in MD. Using UK Biobank cohort, the authors defined 16 MD subtypes within eight comparison grou...	10.1038/s41380-021-01413-6	350	Depression	우울증 질병의 이해
96	Psychopathology of Mixed States	Mixed states are frequent clinical pictures in psychiatric practice but are not well described in nosologic systems. Debate exists as to defining mixed states. We review factor and cluster analytical studies and prominent clinical/conceptual models of mixed states. While mania involves standard manic symptoms and depre...	10.1016/j.psc.2019.10.003	104	Depression	우울증 질병의 이해
97	Overlapping and segregated changes of functional hubs in melancholic depression and non-melancholic depression	Background: Previous research found associations between neuropsychiatric disorders and patterns of highly connected "hub" nodes, which are crucial in coordinating brain functions. Melancholic depression is considered a relatively distinct and homogenous subtype of major depressive disorder (MDD), which responds better...	10.1016/j.jpsychires.2022.07.043	358	Depression	우울증 질병의 이해
98	The utility of a classificatory decision tree approach to assist clinical differentiation of melancholic and non-melancholic depression	Background: Studies suggest that differentiating melancholic from non-melancholic depressive disorders is advanced by use of illness course as well as symptom variables but, in practice, potentially differentiating variables are generally positioned as having equal value. Judging that differentiating features are more ...	10.1016/j.jad.2015.03.057	402	Depression	우울증 질병의 이해
99	The endocrinology of melancholic and atypical depression: relation to neurocircuitry and somatic consequences	The cardinal clinical manifestations of major depression with melancholic features include sustained anxiety and dread for the future as well as evidence of physiological hyperarousal (e.g., sustained hyperactivity of the two principal effectors of the stress response, the corticotropin-releasing-hormone, or CRH, syste...	10.1046/j.1525-1381.1999.09423.x	360	Depression	우울증 질병의 이해

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