diff --git "a/AttentiveSkin/train.csv" "b/AttentiveSkin/train.csv"
deleted file mode 100644--- "a/AttentiveSkin/train.csv"
+++ /dev/null
@@ -1,16367 +0,0 @@
-Name,Synonym,CAS RN,GHS,Detailed Page,Evidence,OECD TG 404,Data Source,Frequency,SMILES,SMILES URL,SMILES Source,Canonical SMILES,Split,ClusterNo,MolCount,group
-"JP_CHRIP:
-p-Nitrochlorobenzene","JP_CHRIP:
-p-Chloronitrobenzene
-1-Chloro-4-nitrobenzene
-Benzene, 1-chloro-4-nitro-
-Chloronitrobenzenes
-p-Chloronitrobenzene
-PCNB
-PNCB",100-00-5,NC,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-mhlw-2013.html,"JP_CHRIP:
-【分類根拠】
-（１）、（２）より、区分に該当しない（国連分類基準の区分3）とした。なお、新たな知見に基づき、分類結果を変更した。
-
-【根拠データ】
-（１）ウサギ（n= 6）を用いた皮膚刺激性試験（OECD TG 404、GLP、閉塞、24時間適用、8日間観察）において、パッチ除去24及び72時間後の全例の平均スコアは、紅斑ではいずれも0、浮腫では2.17及び1.0であった。48時間値は欠測のため、24時間値と同じと仮定して求めた24/48/72時間の全体の平均スコアは紅斑で0.0、浮腫で1.8であった。本物質は軽微な (slightly) 刺激性を有するとの報告がある（AICIS IMAP (2016)、SIAR (2002)、CERI 有害性評価書 (2008)、REACH登録情報 (Accessed Dec. 2021)）。
-（２）ウサギ（n= 6）を用いた皮膚刺激性試験（OECD TG 404、GLP、原体500 mg、24時間閉塞、72時間観察）において、無傷皮膚では紅斑はみられず、軽微な浮腫（フルスコア４：2.17/4）、有傷皮膚では軽微な紅斑（0.17/4）と軽微な浮腫（1.67/4）がみられ、72時間後には消失した。皮膚刺激指数は0.1（最高8）と算出され、本物質は軽微な (slightly) 刺激性を有するとの報告がある（AICIS IMAP (2016)、SIAR (2002)、REACH登録情報 (Accessed Dec. 2021)）。",Provided,JP_CHRIP,1,[O-][N+](=O)c1ccc(Cl)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.586F,J-GLOBAL,O=[N+]([O-])c1ccc(Cl)cc1,Train,1,2702,training
-"US_HSDB:
-4-Acetylanisole",,100-06-1,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8319,,,US_HSDB,1,CC(=O)C1=CC=C(C=C1)OC,https://pubchem.ncbi.nlm.nih.gov/compound/7476,PubChem,COc1ccc(C(C)=O)cc1,Train,1,2702,training
-"NZ_CCID:
-4-Methoxybenzoyl chloride","NZ_CCID:
-p-anisoyl chloride",100-07-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F8EBA1DF-D76D-47F8-B71E-53EFD7A5E5E9,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,COC1=CC=C(C=C1)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7477,PubChem,COc1ccc(C(=O)Cl)cc1,Train,1,2702,training
-"EU_CLP:
-N,N'-(2,2-dimethylpropylidene)hexamethylenediamine",,1000-78-8,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C)(C)C=NCCCCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/53431421,PubChem,CC(C)(C)C=NCCCCCCN,Test,1,2702,training
-"NZ_CCID:
-4-Nitrobenzyl bromide",,100-11-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/91AAC884-2EC5-43EE-ADB5-AF4DDF1BDE4D,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1CBr)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/66011,PubChem,O=[N+]([O-])c1ccc(CBr)cc1,Train,1,2702,training
-"EU_REACH:
-butyl N-[(butylsulfanyl)methanethioyl]carbamate",,1001320-38-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6482/7/4/2/?documentUUID=b26381a5-2bfb-4410-adef-8d80c8972445,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOC(=O)NC(=S)SCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/87668466,PubChem,CCCCOC(=O)NC(=S)SCCCC,Train,1,2702,training
-"EU_REACH:
-(3R,4R)-3-aminooctan-4-ol; (3R,4S)-3-aminooctan-4-ol; (3S,4R)-3-aminooctan-4-ol; (3S,4S)-3-aminooctan-4-ol",,1001354-72-8,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10826/7/4/2/?documentUUID=b03e03fd-0315-40cd-b7a7-4675fa6b6e25,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(C(CC)N)O,https://pubchem.ncbi.nlm.nih.gov/compound/55284966,PubChem,CCCCC(O)C(N)CC,Test,1,2702,training
-"NZ_CCID:
-4-Nitrobenzyl chloride",,100-14-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1510B53F-7AAE-42B1-A0B1-7A4B8637026C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC(=CC=C1CCl)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/7482,PubChem,O=[N+]([O-])c1ccc(CCl)cc1,Train,1,2702,training
-"EU_CLP:
-isobutyl 3,4-epoxybutyrate",,100181-71-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C)COC(=O)CC1CO1,https://pubchem.ncbi.nlm.nih.gov/compound/5463767,PubChem,CC(C)COC(=O)CC1CO1,Test,1,2702,training
-"JP_CHRIP:
-Terephthaloyl dichloride
-
-NZ_CCID:
-Terephthaloyl dichloride","JP_CHRIP:
-1.4-benzenedicarbonyl dichloride
-p-phenylenedicarbonyl dichloride
-terephthalic acid dichloride
-terephthalyl dichloride
-
-NZ_CCID:
-terephthaloyl chloride",100-20-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0074e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3415792D-6F89-47E8-B3EB-6F93BCA3F575","JP_CHRIP:
-The substance was classified in Category 1 because it is described that it is a skin irritant (HSDB (2003)), and there is a description of pH < 0.5 (MSDS (Merck, 2010)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,ClC(=O)c1ccc(cc1)C(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.979D,J-GLOBAL,O=C(Cl)c1ccc(C(=O)Cl)cc1,Train,1,2702,training
-"NZ_CCID:
-Isocinchomeronic acid","NZ_CCID:
-2,5-pyridinedicarboxylic acid",100-26-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1387B5AE-673A-4BE1-B0D9-50E520E55BA7,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=NC=C1C(=O)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7493,PubChem,O=C(O)c1ccc(C(=O)O)nc1,Train,1,2702,training
-"EU_CLP:
-8,9,10-trinorborn-2-yl acrylate",,10027-06-2,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C=CC(=O)OC1CC2CCC1C2,https://pubchem.ncbi.nlm.nih.gov/compound/111992,PubChem,C=CC(=O)OC1CC2CCC1C2,Test,1,2702,training
-"NZ_CCID:
-Cyclopentylamine",,1003-03-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/25576493-C465-4795-BDD8-E97FB52607E5,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CCC(C1)N,https://pubchem.ncbi.nlm.nih.gov/compound/2906,PubChem,NC1CCCC1,Train,1,2702,training
-"NZ_CCID:
-4-Ethoxybenzaldehyde","NZ_CCID:
-Benzaldehyde, p-ethoxy-",10031-82-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2311351F-B6B9-454E-8F94-76FDBF8FFF29,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]",,NZ_CCID,1,CCOC1=CC=C(C=C1)C=O,https://pubchem.ncbi.nlm.nih.gov/compound/24834,PubChem,CCOc1ccc(C=O)cc1,Train,1,2702,training
-"EU_REACH:
-1-butoxy-4-[4-(trans-4-ethylcyclohexyl)-1-cyclohexen-1-yl]-2,3-difluorobenzene",,1003218-33-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/28033/7/4/2/?documentUUID=9293756a-8d9d-48f0-9bab-e779b47322a2,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOC1=C(C(=C(C=C1)C2=CCC(CC2)C3CCC(CC3)CC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/147298660,PubChem,CCCCOc1ccc(C2=CCC(C3CCC(CC)CC3)CC2)c(F)c1F,Train,1,2702,training
-"JP_CHRIP:
-N,N-Diethylenediamine
-
-NZ_CCID:
-2-Aminoethyldiethylamine","JP_CHRIP:
-1-Amino-2-(N,N-diethylamino)ethane
-
-NZ_CCID:
-N,N-diethylethylenediamine",100-36-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0148e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/97B2A5DA-AE60-41B7-9155-AB34A9F616E2","JP_CHRIP:
-Since a solution of the substance has a pH of 11.6 (20 degC, 10 g/L) (GESTIS (access on Oct. 2009)), the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-UN CLASS: 8; 3; Packing Group II",,"JP_CHRIP, NZ_CCID",2,CCN(CC)CCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J25.753B,J-GLOBAL,CCN(CC)CCN,Train,1,2702,training
-"AU_HCIS:
-Ethanol, 2-(diethylamino)-
-
-JP_CHRIP:
-Ethanol, 2-(diethylamino)-
-
-NZ_CCID:
-2-Diethylaminoethanol","AU_HCIS:
-2-diethylaminoethanol
-N,N-diethylethanolamine
-
-JP_CHRIP:
-2-(Diethylamino)ethanol
-2-Diethylaminoethyl alcohol
-DEAE
-N,N-Diethylethanolamine
-
-NZ_CCID:
-(2-Hydroxyethyl)diethylamine, 2-(Diethylamino)ethanol, 2-(Diethylamino)ethyl alcohol, 2-(N,N-Diethylamino)ethanol, 2-Hydroxytriethylamine, 2-N-Diethylaminoethanol, DEAE, Diethylamino ethanol, Diethylaminoethanol, Diethylethanolamine, Diethylmonoethanolamine, Ethanol, 2-(diethylamino)-, N,N-Diethyl-2-aminoethanol, N,N-Diethyl-2-hydroxyethylamine, N,N-Diethylethanolamine, N,N-Diethylmonoethanolamine, Pennad 150",100-37-8,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1878
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-2011e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EA912E8C-526D-4362-907D-514458CD8041","JP_CHRIP:
-In the rabbit test (OECD TG 404), occlusive application of the substance for 3 minutes up to 4 hours caused necrosis and resulted that the substance was corrosive (SIDS (Access on Jun. 2009)). Similarly, in other reports of rabbit tests, necrosis was observed and resulted that the substance was corrosive (SIDS (Access on Jun. 2009)). Based on these test results, the substance was classified as Category 1. As relevant information, the substance was classified as ""R34"" in the EU classification (EU Annex I (2006)).
-
-NZ_CCID:
-Skin Irritation
-R-PHRASE: R 34 Causes burns. [ECB- Annex - 1]
-Eye Irritation
-R-PHRASE: R 34 Causes burns. [ECB- Annex - 1]",Provided,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CCN(CC)CCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.982D,J-GLOBAL,CCN(CC)CCO,Train,1,2702,training
-"EU_REACH:
-[(6-chloropyridin-3-yl)methyl](2,2-difluoroethyl)amine",,1003859-14-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6647/7/4/2/?documentUUID=3cae490c-6772-46dc-924a-7eefd4d9d659,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=NC=C1CNCC(F)F)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/44604123,PubChem,FC(F)CNCc1ccc(Cl)nc1,Train,1,2702,training
-"NZ_CCID:
-2-(Diethylamino)ethanethiol",,100-38-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2DF8FD8E-7AC0-42C9-BA12-3F0E596D26B8,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCN(CC)CCS,https://pubchem.ncbi.nlm.nih.gov/compound/16032,PubChem,CCN(CC)CCS,Train,1,2702,training
-"JP_CHRIP:
-Benzyl bromide
-
-NZ_CCID:
-Benzyl bromide","JP_CHRIP:
-alpha-bromotoluene
-Bromophenylmethane",100-39-0,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2069e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4B343E20-A7AD-4FC9-9C5E-90D836220843","JP_CHRIP:
-There is a description that it is severely irritating and corrosive by contact with this substance (HSDB (Access on June 2017)). Since the description concerning corrosivity was not clear, it was classified in Category 2. Besides, in the EU CLP classification, this substance was classified as ""Skin Irrit. 2, H315"" (ECHA CL Inventory (Access on June 2017)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,"JP_CHRIP, NZ_CCID",2,BrCc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.230A,J-GLOBAL,BrCc1ccccc1,Train,1,2702,training
-"EU_REACH:
-2-[(4-methyl-2-nitrophenyl)amino]ethan-1-ol",,100418-33-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22442/7/4/2/?documentUUID=a5994755-30cf-4571-b3d8-f238c9372ba2,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)NCCO)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/10130360,PubChem,Cc1ccc(NCCO)c([N+](=O)[O-])c1,Train,1,2702,training
-"JP_CHRIP:
-Styrene
-
-KR_NCIS:
-Vinylbenzene; Styrene, Ethenylbenzene
-
-NZ_CCID:
-Benzene, ethenyl-
-
-US_HSDB:
-Styrene","JP_CHRIP:
-Ethenylbenzene
-Phenylethylene
-stylene
-Styrol
-Vinylbenzene
-
-NZ_CCID:
-Cinnamene, Phenethylene, Phenylethylene, Styrene, Styrol, Vinyl benzene",100-42-5,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2111e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9D0EF7F2-8C6E-423B-B5A2-C6D3FC4EC55B
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/171","JP_CHRIP:
-[Rationale for the Classification]
-It was classified in Category 2 from (1) - (3).
-
-[Evidence Data]
-(1) Exposure to this substance resulted in irritation of the eyes and skin in humans (JECFA FAS 19 (1984)).
-(2) This substance irritated the eye, skin, and respiratory tract, and erythema and pain occurred after an entry into the eye or contact with the skin (Environmental Risk Assessment for Chemical Substances vol. 13 (Ministry of the Environment, 2015), HSDB (Access on August 2020)).
-(3) Marked irritation with denaturation of the skin was noted when this substance was applied to the skin of rabbits for 4 weeks (20,000 mg/kg) (ATSDR (2010)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Irritating
-REFERENCE SOURCE: REPSOL QUIMICA, S.A. MADRID (215) Union Carbide Data Sheet. 12/13/63
-[IUCLID 2000]
-REMARK: EC Classification: Irritating
-
-Eye Irritation
-R-PHRASE: R 36 Irritating to eyes. [IUCLID 2000].",,"JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",4,C=Cc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.006A,J-GLOBAL,C=Cc1ccccc1,Train,1,2702,training
-"EU_CLP:
-α-chlorotoluene; benzyl chloride",,100-44-7,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC=C(C=C1)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/7503,PubChem,ClCc1ccccc1,Test,1,2702,training
-"NZ_CCID:
-Benzylamine",,100-46-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CD82B4A8-1C71-4F25-8938-3184B0632B04,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)CN,https://pubchem.ncbi.nlm.nih.gov/compound/7504,PubChem,NCc1ccccc1,Train,1,2702,training
-"NZ_CCID:
-4-Pyridinecarbonitrile","NZ_CCID:
-4-cyanopyridine",100-48-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2835D7FB-32F7-4186-91FD-67AD99353267,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CN=CC=C1C#N,https://pubchem.ncbi.nlm.nih.gov/compound/7506,PubChem,N#Cc1ccncc1,Train,1,2702,training
-"ChemSkin:
-Benzyl alcohol",,100-51-6,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,C1=CC=C(C=C1)CO,https://pubchem.ncbi.nlm.nih.gov/compound/244,PubChem,OCc1ccccc1,Test,1,2702,training
-"NZ_CCID:
-3-Pyridylmethanol","NZ_CCID:
-3-pyridylcarbinol",100-55-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F4B8ACC1-6B74-4E23-B5F9-748D3DF99811,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CN=C1)CO,https://pubchem.ncbi.nlm.nih.gov/compound/7510,PubChem,OCc1cccnc1,Train,1,2702,training
-"NZ_CCID:
-Phenyl thioxochloroformate","NZ_CCID:
-o-Phenyl chlorothioformate, phenyl chlorothionoformate",1005-56-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B4CCF7E2-9E9A-41BC-84E8-9D55BF24A78F,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 34. [Company Data]
-Eye Irritation
-R-PHRASE: R 34. [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)OC(=S)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/70498,PubChem,S=C(Cl)Oc1ccccc1,Train,1,2702,training
-"NZ_CCID:
-Cyclohexyl(methyl)amine","NZ_CCID:
-N-methylcyclohexylamine",100-60-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E393DAB0-EBE1-4010-8ED3-B2B2870B2B31,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CNC1CCCCC1,https://pubchem.ncbi.nlm.nih.gov/compound/7514,PubChem,CNC1CCCCC1,Train,1,2702,training
-"JP_CHRIP:
-N-Methylaniline","JP_CHRIP:
-Monomethylaniline
-N-Methylbenzenamine
-N-Methylphenylamine",100-61-8,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0071e.html,"JP_CHRIP:
-Based on human epidemiological findings of ""skin irritation"" (CERI Hazard Data 2001-2 (2002)). Although classified into Category 2-3 because the severity of irritation is unknown, the substance should be placed in Category 2A from the viewpoint of safety.",,JP_CHRIP,1,CNc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.591B,J-GLOBAL,CNc1ccccc1,Train,1,2702,training
-"AU_HCIS:
-phenylhydrazine
-
-JP_CHRIP:
-Phenylhydrazine
-
-KR_NCIS:
-Phenylhydrazine
-
-NZ_CCID:
-Phenylhydrazine","JP_CHRIP:
-Phenylhydrazine
-Hydrazinobenzene
-Monophenylhydrazine
-
-KR_NCIS:
-Hydrazinobenzene
-
-NZ_CCID:
-Hydrazine, phenyl-, Hydrazinobenzene, Monophenylhydrazine",100-63-0,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3496
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2004e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/79773D2B-D8D2-4BFE-A3F4-050EC72AFEE6","JP_CHRIP:
-[Rationale for the Classification]
-According to (1)-(4), many findings show irritation, and it was classified in Category 2.
-
-[Evidence Data]
-(1) There is a report that superficial erythema and bullous-papular were observed at the contact area (arm) of workers accidentally exposed to phenylhydrazine hydrochloride powder (CICAD 19 (2000), NICNAS IMAP (Accessed Jun. 2018)).
-(2) There is a report that plural burns and small blisters were observed at the contact area (hands or feet through the gloves or shoes) of workers accidentally exposed to phenylhydrazine hydrochloride powder (CICAD 19 (2000), NICNAS IMAP (Accessed Jun. 2018)).
-(3) There is information that there are plural reports of irritation in humans (DFGOT vol.11 (1998)).
-(4) There are reports that in animal test data with rabbits and rats, skin irritation occurred at high frequency, and necrosis and sloughing were observed in some animals (Fundam Appl Toxicol. 1987, 8(4), 583-94).
-
-[Reference Data, etc.]
-(5) The Ministry of Health, Labour and Welfare concluded that this substance shows irritation/corrosion (Initial Risk Assessment Report (Ministry of Health, Labour and Welfare, 2013)).
-(6) This substance was classified as ""Skin Irrit. 2"" by EU CLP.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID",4,NNc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J38.250G,J-GLOBAL,NNc1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-2-Vinylpyridine
-
-NZ_CCID:
-2-Vinylpyridine (stabilized with 4-t-butylpyrocatechol)","JP_CHRIP:
-2-Vinylpyridine
-2-Ethenylpyridine
-2-Ethylpyridine
-2-Pyridylethylene
-alpha-Vinylpyridine
-Pyridine, 2-ethenyl-
-
-NZ_CCID:
-2-vinylpyridine",100-69-6,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-meti-0008e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3A61356D-51AF-46DA-9905-7A574440768A","JP_CHRIP:
-There is a report that in a study using rabbits, as a result of the application of 0.5 ml of an undiluted solution of this substance for 1 hour, necrosis was observed (SIDS (2014)). In addition, it is described that this substance caused strong irritation to rabbits (PATTY (6th, 2012)). Moreover, there is a report that this substance caused skin burns after contact with human skin, and the site of inflammation became reddish-brown and took about a month to disappear (Initial Risk Assessment Report (NITE, CERI, NEDO,2005), PATTY (6th, 2012)). From the above, this substance was classified in Category 1.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,C=Cc1ccccn1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J38.336H,J-GLOBAL,C=Cc1ccccn1,Train,1,2702,training
-"NZ_CCID:
-2-Ethylpyridine",,100-71-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/24B1F831-FDA0-4BA2-B315-95371D76CBC1,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCC1=CC=CC=N1,https://pubchem.ncbi.nlm.nih.gov/compound/7523,PubChem,CCc1ccccn1,Train,1,2702,training
-"JP_CHRIP:
-N-Ethylmorpholine","JP_CHRIP:
-Morpholine, 4-ethyl-
-N-Ethylmorphorine",100-74-3,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2016e.html,"JP_CHRIP:
-In a skin irritation test with rabbits (equivalent to OECD TG 404), moderate to severe irritation such as erythema and edema were observed 24 hours after application on application of this substance for 1-15 minutes or 20 hours, and necrosis was observed after 8 days on application for 5 minutes or above (SIDS (2007)). Based on this newly added test information, this substance was judged to be corrosive, and it was classified in Category 1B. The category was changed by adding the test information.",Provided,JP_CHRIP,1,CCN1CCOCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.428H,J-GLOBAL,CCN1CCOCC1,Train,1,2702,training
-"JP_CHRIP:
-Methyl 3-chloro-5-(4,6-dimethoxy-2-pyrimidinylcarbamoylsulfamoyl)-1-methylpyrazole-4-carboxylate; Halosulfuron-methyl",,100784-20-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2124e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified as ""Not classified"" from (1), (2).
-
-[Evidence Data]
-(1) In a skin irritation test with rabbits according to OECD TG 404 on this substance, no skin reactions were seen, and it was judged as not a skin irritant (RAC Background Document (2017)).
-(2) In a skin irritation test with rabbits, no irritation was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014), EU EFSA (2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2008)).",Provided,JP_CHRIP,1,COC(=O)c1c(Cl)nn(C)c1S(=O)(=O)NC(=O)Nc1nc(OC)cc(OC)n1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J640.666A,J-GLOBAL,COC(=O)c1c(Cl)nn(C)c1S(=O)(=O)NC(=O)Nc1nc(OC)cc(OC)n1,Train,1,2702,training
-"EU_REACH:
-(2,2-dimethyl-1,3-dioxolan-4-yl)methanol",,100-79-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12258/7/4/2/?documentUUID=8dbc09df-a4a0-4e0f-8547-8638bbea689e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(OCC(O1)CO)C,https://pubchem.ncbi.nlm.nih.gov/compound/7528,PubChem,CC1(C)OCC(CO)O1,Train,1,2702,training
-"US_HSDB:
-3-Vinyltoluene",,100-80-1,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8450,,,US_HSDB,1,CC1=CC(=CC=C1)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/7529,PubChem,C=Cc1cccc(C)c1,Train,1,2702,training
-"EU_REACH:
-4-(2-phenylpropan-2-yl)-N-[4-(2-phenylpropan-2-yl)phenyl]aniline",,10081-67-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13882/7/4/2/?documentUUID=b12c4b0f-ec38-4481-8b65-202c331af8d8,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C1=CC=CC=C1)C2=CC=C(C=C2)NC3=CC=C(C=C3)C(C)(C)C4=CC=CC=C4,https://pubchem.ncbi.nlm.nih.gov/compound/82343,PubChem,CC(C)(c1ccccc1)c1ccc(Nc2ccc(C(C)(C)c3ccccc3)cc2)cc1,Test,1,2702,training
-"NZ_CCID:
-2-Phenylpyridine",,1008-89-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BE0F37CC-C31C-4A0F-B273-E65B86397724,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)C2=CC=CC=N2,https://pubchem.ncbi.nlm.nih.gov/compound/13887,PubChem,c1ccc(-c2ccccn2)cc1,Train,1,2702,training
-"EU_REACH:
-1-[4-({4-[(dimethylcarbamoyl)amino]phenyl}methyl)phenyl]-3,3-dimethylurea",,10097-09-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24294/7/4/2/?documentUUID=bd4a58d8-ad15-46a8-af6e-ff4a6e1c0497,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C)C(=O)NC1=CC=C(C=C1)CC2=CC=C(C=C2)NC(=O)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/305607,PubChem,CN(C)C(=O)Nc1ccc(Cc2ccc(NC(=O)N(C)C)cc2)cc1,Train,1,2702,training
-"JP_CHRIP:
-triphenyl phosphite
-
-KR_NCIS:
-Triphenyl phosphite
-
-NZ_CCID:
-Triphenyl phosphite","JP_CHRIP:
-Phosphorous acid, triphenyl ester
-Triphenoxyphosphine
-
-KR_NCIS:
-Phosphorous acid, triphenyl ester; Phenyl phosphite; Trimphenoxyphosphine
-
-NZ_CCID:
-Phosphorous acid, triphenyl ester, Tris(phenoxy)phosphine",101-02-0,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0152e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7A769EFC-8A65-4FAD-B318-FAD297074DDE","JP_CHRIP:
-Draize tests using rabbits found that the substance is moderately irritating (IUCLID (2000)). In addition, it is rated as Xi; R36/38 in the EU classification. Thus, the substance is classified into Category 2.
-
-NZ_CCID:
-Skin Irritation
-REMARK: C = 25 %: Xi, N; R36/38-50/53
-5 % = C < 25 %: Xi, N; R36/38-51/53
-REFERENCE SOURCE: [ecb classification and labelling]
-Eye Irritation
-REMARK: C = 25 %: Xi, N; R36/38-50/53
-5 % = C < 25 %: Xi, N; R36/38-51/53
-REFERENCE SOURCE: [ECB]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,O(P(Oc1ccccc1)Oc1ccccc1)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.594G,J-GLOBAL,c1ccc(OP(Oc2ccccc2)Oc2ccccc2)cc1,Train,1,2702,training
-"EU_CLP:
-anilazine (ISO); 2-chloro-N-(4,6-dichloro-1,3,5-triazin-2-yl)aniline",,101-05-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC=C(C(=C1)NC2=NC(=NC(=N2)Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7541,PubChem,Clc1nc(Cl)nc(Nc2ccccc2Cl)n1,Test,1,2702,training
-"EU_REACH:
-2,5-bis(phenylamino)benzene-1,4-dicarboxylic acid",,10109-95-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12394/7/4/2/?documentUUID=1c95dd29-c148-43c7-b224-ce6ad09e38e1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)NC2=CC(=C(C=C2C(=O)O)NC3=CC=CC=C3)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/82351,PubChem,O=C(O)c1cc(Nc2ccccc2)c(C(=O)O)cc1Nc1ccccc1,Train,1,2702,training
-"ChemSkin:
-1-(4-Chlorophenyl)-3-(3,4-dichlorophenyl) urea",,101-20-2,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,C1=CC(=CC=C1NC(=O)NC2=CC(=C(C=C2)Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7547,PubChem,O=C(Nc1ccc(Cl)cc1)Nc1ccc(Cl)c(Cl)c1,Test,1,2702,training
-"EU_REACH:
-C,C-Diphenylmethyleneimine",,1013-88-3,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30821/7/4/2/?documentUUID=8929749d-fc69-4ef4-a660-5075bbb35f17,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C(=N)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/136809,PubChem,N=C(c1ccccc1)c1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-N-({4-[2-Chloro-4-(trifluoromethyl)phenoxy]-2-fluorophenyl}carbamoyl)-2,6-difluorobenzamide; Flufenoxuron",,101463-69-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0081e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified as ""Not classified"" from (1).
-
-[Evidence Data]
-(1) It is reported that in a skin irritation test with rabbits (n = 6) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 7-day observation), no irritation changes were seen in any animal (erythema/eschar score: 0/0/0/0/0/0, edema score: 0/0/0/0/0/0) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014), ECHA RAC Opinion (2011), CLH Report (2009), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2015)).",Provided,JP_CHRIP,1,Fc1cc(Oc2ccc(cc2Cl)C(F)(F)F)ccc1NC(=O)NC(=O)c1c(F)cccc1F,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J228.145G,J-GLOBAL,O=C(NC(=O)c1c(F)cccc1F)Nc1ccc(Oc2ccc(C(F)(F)F)cc2Cl)cc1F,Train,1,2702,training
-"NZ_CCID:
-1-Propanesulphonyl chloride",,10147-36-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/80F56582-6FF9-4B82-85C7-7A4A786E29E1,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCCS(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/66279,PubChem,CCCS(=O)(=O)Cl,Train,1,2702,training
-"EU_CLP:
-3,5-dichloro-2,4-difluorobenzoyl fluoride",,101513-70-6,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=C(C(=C(C(=C1Cl)F)Cl)F)C(=O)F,https://pubchem.ncbi.nlm.nih.gov/compound/5463764,PubChem,O=C(F)c1cc(Cl)c(F)c(Cl)c1F,Test,1,2702,training
-"JP_CHRIP:
-N-Phenyl-1,4-benzenediamine","JP_CHRIP:
-4-Aminodiphenylamine
-N-(4-Aminophenyl)aniline
-N-Phenyl-p-phenylenediamine",101-54-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0025e.html,"JP_CHRIP:
-In the rabbit test (OECD TG 404) treated with 0.5g of test substance for 4 hours, the average score of erythema and edema were 0 at all observation points, i.e. not irritating (SIDS (2004)). Based on the documents, the substance was classified as ""Not classified"". As relevant information, in volunteers tests, obvious irritation was not observed for 2-hour exposure, but transient irritation was observed in 4-hour exposure in half the people. Obvious erythema was observed for 24-hour exposure, but disappeared in a week (BUA 131 (1993)).",Provided,JP_CHRIP,1,Nc1ccc(Nc2ccccc2)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.017G,J-GLOBAL,Nc1ccc(Nc2ccccc2)cc1,Train,1,2702,training
-"EU_REACH:
-(3R,3aR,6R,6aR)-6-(3-methoxy-4-{3-methoxy-4-[4-(prop-2-enoyloxy)benzoyloxy]benzoyloxy}benzoyloxy)-hexahydrofuro[3,2-b]furan-3-yl 3-methoxy-4-[4-(prop-2-enoyloxy)benzoyloxy]benzoate; (3R,3aR,6R,6aR)-6-(3-methoxy-4-{4-[4-(prop-2-enoyloxy)benzoyloxy]benzoyloxy}benzoyloxy)-hexahydrofuro[3,2-b]furan-3-yl 3-methoxy-4-[4-(prop-2-enoyloxy)benzoyloxy]benzoate; (3S,3aS,6S,6aS)-6-{3-methoxy-4-[4-(prop-2-enoyloxy)benzoyloxy]benzoyloxy}-hexahydrofuro[3,2-b]furan-3-yl 3-methoxy-4-[4-(prop-2-enoyloxy)benzoyloxy]benzoate",,1015689-48-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1763/7/4/2/?documentUUID=c3feae7f-6d7f-426a-a684-7574a6fa1859,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=C(C=CC(=C1)C(=O)O[C@@H]2CO[C@H]3[C@@H]2OC[C@H]3OC(=O)C4=CC(=C(C=C4)OC(=O)C5=CC=C(C=C5)OC(=O)C=C)OC)OC(=O)C6=CC=C(C=C6)OC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/66690863,PubChem,C=CC(=O)Oc1ccc(C(=O)Oc2ccc(C(=O)O[C@@H]3CO[C@H]4[C@@H]3OC[C@H]4OC(=O)c3ccc(OC(=O)c4ccc(OC(=O)C=C)cc4)c(OC)c3)cc2OC)cc1,Train,1,2702,training
-"AU_HCIS:
-Benzene, 1,1'-methylenebis[4-isocyanato-
-
-JP_CHRIP:
-Methylenebis(4,1-phenylene) diisocyanate [4'4-MDI]
-
-KR_NCIS:
-Diphenylmethane 4,4'-diisocyanate
-
-NZ_CCID:
-Methylene, 4,4'-diphenyl diisocyanate-","AU_HCIS:
-4,4'-methylenediphenyl diisocyanate
-diphenylmethane-4,4'-diisocyanate
-methylene bisphenyl isocyanate (MDI)
-4,4'-Methylenebis(phenyl isocyanate)
-
-JP_CHRIP:
-4,4'-MDI
-4,4'-methylenebis(phenyl isocyanate) (synonym:methylenebis(4,1-phenylene) diisocyanate)
-4,4'-methylenediphenyl diisocyanate
-4,4'-Methylenediphenyldiisocyanate
-bis(1,4-Isocyanatophenyl)methane
-Diphenylmethane-4.4'-diisocyanate
-MDI
-Methylene Diphenyl Diisocyanate
-Methylenebis(4,1-phenylene) diisocyanate
-monomeric MDI
-
-KR_NCIS:
-Diphenyl methane diisocyanate; 4,4'-Methylenediphenyldiisocyanate
-
-NZ_CCID:
-BIS(PARA-ISOCYANATOPHENYL)METHANE BIS(PARA-ISOCYANATOPHENYL)METHANE BIS(PARA-ISOCYANATOPHENYL)METHANE BIS(PARA-ISOCYANATOPHENYL)METHANE, MDI, Methylene diphenyl diisocyanate, Methylenebis(4-phenylisocyanate)",101-68-8,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=363
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0104e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/74E4A88A-4C96-4B0F-8410-B43A431B70A9","JP_CHRIP:
-There is a report that this substance was irritating to human skin (EU-RAR (2005)). In addition, there are reports that this substance was irritating to rabbit skin (EU-RAR (2005), IARC 71 (1999)), and that it was slightly irritating (EU-RAR (2005)). From the above, it was classified in Category 2. Besides, this substance was classified as ""Skin. Irrit. 2 H315"" in EU CLP classification (ECHA CL Inventory (Access on September 2015)).
-
-NZ_CCID:
-Skin Irritation
-R-PHRASE: R 38. [NIOSH ICSC]
-Eye Irritation
-R-PHRASE: R 36. [NIOSH ICSC]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID",4,O=C=Nc1ccc(Cc2ccc(cc2)N=C=O)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.231J,J-GLOBAL,O=C=Nc1ccc(Cc2ccc(N=C=O)cc2)cc1,Train,1,2702,training
-"JP_CHRIP:
-dicyclohexylamine
-
-KR_NCIS:
-Dicyclohexylamine
-
-NZ_CCID:
-Dicyclohexylamine","JP_CHRIP:
-Dodecahydrodiphenylamine
-N,N-Dicyclohexylamine
-N-Cyclohexylcyclohexanamine
-
-KR_NCIS:
-N-Cyclohexylcyclohexanamine; dodecahydrodiphenylamine
-
-NZ_CCID:
-Cyclohexanamine, N-cyclohexyl-",101-83-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0028e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F5A530CA-7137-4345-AEC4-1ABD54D8C8C2","JP_CHRIP:
-In primary skin irritation tests, the substance was topically applied onto 6 rabbits for 24 hours, and during the 21-day observation, the average scores of the Primary Dermal Irritation Index after 24-72 hours indicated that the substance was corrosive (HSDB (2003)). Other tests also reported that the substance was highly corrosive (IUCLID (2000)) or causes immediate necrosis (IUCLID (2000)). Thus, the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-REMARK: EU Classifications (Directive 67/548/EEC):
-C ?25%: C,N; R22-34-50/53
-10% ? C<25%: C,N; R34-51/53
-2.5% ? C<10%: Xi,N; R36/38-51/53
-2% ? C<2.5%: Xi,; R36/38-52/53
-0.25% ? C<2%: R52/53
-Eye Irritation
-REMARK: EU Classifications (Directive 67/548/EEC):
-C ?25%: C,N; R22-34-50/53
-10% ? C<25%: C,N; R34-51/53
-2.5% ? C<10%: Xi,N; R36/38-51/53
-2% ? C<2.5%: Xi,; R36/38-52/53
-0.25% ? C<2%: R52/53",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,C1CCC(CC1)NC1CCCCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.018E,J-GLOBAL,C1CCC(NC2CCCCC2)CC1,Train,1,2702,training
-"AU_HCIS:
-Octanal, 2-(phenylmethylene)-
-
-JP_CHRIP:
-2-Benzylideneoctanal",,101-86-0,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5438
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0071e.html","JP_CHRIP:
-In three primary skin irritation tests (OECD TG 404) in rabbits, erythema (grade 1 to 2) and edema (grade 1 to 3) were observed 24 to 72 hours after application, and desquamation was observed on day 7. A primary irritation index (PII) of the three tests was 4.0, 4.0 and 2.58, respectively (ECETOC TR66 (1995)). Therefore, the substance was classified in Category 2.",Provided,"AU_HCIS, JP_CHRIP",2,CCCCCCC(=Cc1ccccc1)C=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J208.614J,J-GLOBAL,CCCCCCC(C=O)=Cc1ccccc1,Train,1,2702,training
-"AU_HCIS:
-resorcinol diglycidyl ether
-
-JP_CHRIP:
-1,3-Bis[(2,3-epoxypropyl)oxy]benzene
-
-KR_NCIS:
-2,2'-[1,3-Phenylenebis(oxymethylene)]bis[oxirane]
-
-NZ_CCID:
-1,3-Bis(2,3-epoxypropoxy) benzene resorcinol diglycidyl ether","AU_HCIS:
-1,3-bis(2,3-epoxypropoxy)benzene
-Oxirane, 2,2'-[1,3-phenylenebis(oxymethylene)]bis-
-
-JP_CHRIP:
-1,3-Bis[(2,3-epoxypropyl)oxy]benzene
-1,3-Diglycidyloxybenzene
-Diglycidyl resorcinol ether
-m-bis(2,3-Epoxypropoxy)benzene
-
-KR_NCIS:
-1,3-Bis(2,3-epoxypropoxy)benzene; 1,3-Diglycidyloxybenzene; 2-[[3-(Oxiran-2-ylmethoxy)phenoxy]methyl]oxirane; Diglycidyl resorcinol ether; m-Bis(2,3-epoxypropoxy)benzene; Oxirane, 2,2'-[1,3-phenylenebis(oxymethylene)]bis-; Resorcinol diglycidyl ether
-
-NZ_CCID:
-diglycidyl resorcinol ether",101-90-6,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4089
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2097e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F42378C4-60FD-49B2-9E18-C394A00707E6","JP_CHRIP:
-[Rationale for the Classification]
-Based on (1)-(5), it was classified in Category 2.
-
-[Evidence Data]
-(1) In a skin irritation test (Draize method) with rabbits, the skin irritation score was 5 (maximum 8), indicating moderate irritation (PATTY (6th, 2012)).
-(2) This substance is irritating to the skin and mucous membranes (DFGOT vol.7 (1996)).
-(3) Contact with this substance causes severe skin irritation in humans (DFGOT vol.7 (1996)).
-(4) This substance is moderately to highly irritating to the skin (HSDB (Access on October 2019)).
-(5) This substance is highly irritating to the skin and mucous membranes (GESTIS (Access on October 2019)).
-
-[Reference Data, etc.]
-(6) It was classified in ""Skin Irrit. 2 (H315)"" in the EU-CLP classification (EU CLP classification (Access on October 2019)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]
-Eye Irritation
-R PHRASE: R 36 [ECB]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID",4,C(Oc1cccc(OCC2CO2)c1)C1CO1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J182.147D,J-GLOBAL,c1cc(OCC2CO2)cc(OCC2CO2)c1,Train,1,2702,training
-"EU_REACH:
-3-[(2-sulfanylacetyl)oxy]-2,2-bis({[(2-sulfanylacetyl)oxy]methyl})propyl 2-sulfanylacetate",,10193-99-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24985/7/4/2/?documentUUID=c5bb677b-60dd-4a0d-bc90-0eb46ee84a0b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(C(=O)OCC(COC(=O)CS)(COC(=O)CS)COC(=O)CS)S,https://pubchem.ncbi.nlm.nih.gov/compound/82441,PubChem,O=C(CS)OCC(COC(=O)CS)(COC(=O)CS)COC(=O)CS,Train,1,2702,training
-"EU_REACH:
-5-[(4-carboxybutanoyl)peroxy]-5-oxopentanoic acid",,10195-54-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23473/7/4/2/?documentUUID=711b4bbb-253e-41b7-8158-6e607ac38f9c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CC(=O)O)CC(=O)OOC(=O)CCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/44150802,PubChem,O=C(O)CCCC(=O)OOC(=O)CCCC(=O)O,Train,1,2702,training
-"EU_REACH:
-3-oxo-N-phenylbutanamide",,102-01-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14590/7/4/2/?documentUUID=3e2a0e7f-dbc5-4f8d-be29-1e80b325a8b5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)CC(=O)NC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/7592,PubChem,CC(=O)CC(=O)Nc1ccccc1,Train,1,2702,training
-"NZ_CCID:
-(R)-(+)-4-Benzyl-2-oxazolidinone",,102029-44-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/102C11A0-4EE5-4B33-960A-BE6348E0E190,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1[C@H](NC(=O)O1)CC2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/2734969,PubChem,O=C1N[C@H](Cc2ccccc2)CO1,Train,1,2702,training
-"EU_CLP:
-1,3-diphenylguanidine",,102-06-7,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC=C(C=C1)NC(=NC2=CC=CC=C2)N,https://pubchem.ncbi.nlm.nih.gov/compound/7594,PubChem,NC(=Nc1ccccc1)Nc1ccccc1,Test,1,2702,training
-"EU_REACH:
-1,3-diphenyl-2-thiourea",,102-08-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11688/7/4/2/?documentUUID=59cb1c86-0977-4bb0-9285-4f37622e5820,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)NC(=S)NC2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/700999,PubChem,S=C(Nc1ccccc1)Nc1ccccc1,Train,1,2702,training
-"EU_CLP:
-4-[3-(diethoxymethylsilylpropoxy)-2,2,6,6-tetramethyl]piperidine",,102089-33-8,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCO[Si](C)(CCCOC1CC(NC(C1)(C)C)(C)C)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/54207826,PubChem,CCO[Si](C)(CCCOC1CC(C)(C)NC(C)(C)C1)OCC,Test,1,2702,training
-"JP_CHRIP:
-Diphenyl carbonate",,102-09-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-0004e.html,"JP_CHRIP:
-It was classified as ""Not classified"" because there was no irritationin in the result of skin irritation test with rabbits according to OECD TG 404 (SIDS (2006)).",Provided,JP_CHRIP,1,O=C(Oc1ccccc1)Oc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.004K,J-GLOBAL,O=C(Oc1ccccc1)Oc1ccccc1,Train,1,2702,training
-"EU_CLP:
-1,3-dimethyl-1,3-bis(trimethylsilyl)urea",,10218-17-4,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CN(C(=O)N(C)[Si](C)(C)C)[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/12479153,PubChem,CN(C(=O)N(C)[Si](C)(C)C)[Si](C)(C)C,Test,1,2702,training
-"JP_CHRIP:
-2,2-Dibromo-2-cyanoacetamide (2,2-Dibromo-3-nitrilopropionamide)","JP_CHRIP:
-2,2-Dibromo-3-nitrilopropionamide
-2-Cyano-2,2-dibromoacetamide",10222-01-2,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-meti-2002e.html,"JP_CHRIP:
-[Rationale for the Classification]
-Based on (1), (2), it was classified in Category 2.
-
-[Evidence Data]
-(1) There is a report that in a skin irritation test (OECD TG404, GLP-compliant) in which 0.5 g of this substance (purity 98.2%) was applied to rabbits for 4 hours, the mean scores of 3.3 for erythema and 2.1 for edema were obtained, but they resolved after 14 days (EU CLH proposal document (2018)).
-(2) There is a report that in a skin irritation test in which 0.5 g of this substance was applied to rabbits for 4 hours, erythema and edema occurred, and detachment of the epidermis was observed after 5 days. Based on this, it is judged as moderate skin irritation (EPA Pesticide (1994)).",Provided,JP_CHRIP,1,NC(=O)C(Br)(Br)C#N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J10.480I,J-GLOBAL,N#CC(Br)(Br)C(N)=O,Train,1,2702,training
-"JP_CHRIP:
-3,4-Dichlorophenyl isocyanate",,102-36-3,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0075e.html,"JP_CHRIP:
-It was classified as ""Not classified"" because it was not irritating in a test by a 4-hour application to the rabbit skin (OECD TG404, GLP-compliant) (IUCLID (2000)), and it was not a primary irritant in another test with rabbits (Federal Hazardous Substance Act, Section 191.11) (IUCLID (2000)).",Provided,JP_CHRIP,1,Clc1ccc(cc1Cl)N=C=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J70.203J,J-GLOBAL,O=C=Nc1ccc(Cl)c(Cl)c1,Train,1,2702,training
-"NZ_CCID:
-Glyburide","NZ_CCID:
-Glibenclamide",10238-21-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/89919CF1-F327-433A-B097-938007E38E49,"NZ_CCID:
-Skin Irritation
-REMARK: Confidential information supplied by registrant
-Eye Irritation
-REMARK: Confidential information supplied by registrant",,NZ_CCID,1,COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3,https://pubchem.ncbi.nlm.nih.gov/compound/3488,PubChem,COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1,Train,1,2702,training
-"EU_REACH:
-2,5-dimethoxyaniline",,102-56-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5256/7/4/2/?documentUUID=75420e84-12e6-45f4-8403-ae3b7bea0b88,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC(=C(C=C1)OC)N,https://pubchem.ncbi.nlm.nih.gov/compound/7613,PubChem,COc1ccc(OC)c(N)c1,Train,1,2702,training
-"AU_HCIS:
-Ethanol, 2,2',2''-nitrilotris-
-
-JP_CHRIP:
-Triethanolamine","JP_CHRIP:
-2,2',2''-nitrilotriethanol
-Trihydroxytriethylamine",102-71-6,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1881
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-2023e.html","JP_CHRIP:
-It was classified in Category 2 because it is described in ACGIH (7th, 2001), SIDS (2001), IARC 77 (2000), and NTP TR 518 (2004) that skin irritation was observed after high-concentration exposure or repeated exposure in humans.",,"AU_HCIS, JP_CHRIP",2,OCCN(CCO)CCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J805B,J-GLOBAL,OCCN(CCO)CCO,Train,1,2702,training
-"JP_CHRIP:
-2-(Di-n-butylamino)ethanol","JP_CHRIP:
-2-(Di-n-butylamino)ethanol
-2-(dibutylamino)ethanol
-2-(dibutylamino)ethanol (synonym:2-(di-n-butylamino)ethanol)
-2-Di-N-butylaminoethyl alcohol
-N,N-Dibutyl-N-(2-hydroxyethyl)amine
-N,N-Dibutylethanolamine",102-81-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2013e.html,"JP_CHRIP:
-[Rationale for the Classification]
-Based on (1)-(3), it was classified in Category 1.
-
-[Evidence Data]
-(1) In an occlusive application test with rabbits for 1 minute, 5 minutes and 20 hours, necrosis was observed after 20 hours and it was judged to be corrosive (REACH registration dossier (Access on July 2019)).
-(2) It was reported to be corrosive in a test in which 0.01 mL was applied to rabbits for 24 hours (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)).
-(3) This substance produced necrosis within 24 hours when applied to the skin of rabbits. In addition, when instilled in the eyes, it produced corneal necrosis (ACGIH (7th, 2001)).",,JP_CHRIP,1,CCCCN(CCO)CCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J78.150I,J-GLOBAL,CCCCN(CCO)CCCC,Train,1,2702,training
-"JP_CHRIP:
-Tributan-1-ylamine
-
-KR_NCIS:
-Tributylamine
-
-NZ_CCID:
-1-Butanamine, N,N-dibutyl-
-
-US_HSDB:
-TRIBUTYLAMINE","JP_CHRIP:
-N,N-Dibutyl-1-butanamine
-Tri-n-butylamine
-tributylamine
-Tris-n-butylamine
-
-KR_NCIS:
-1-Butanamine, N,N-dibutyl-; N-N-Dibutyl-butanamine; N-Tributylamine; Tri-N-butylamine; Tris-N-butylamine
-
-NZ_CCID:
-Tributylamine, tri-N-butylamine, tris-N-butylamine",102-82-9,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-meti-0044e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/090AE480-8D16-4F10-9012-B831D4D64676
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/877","JP_CHRIP:
-The irritation of Amines was evaluated as Grade 1-10 in the 24 hour skin irritation test with rabbits and this substance is presumed to be stimulating, because there is a description, ""Grade 4"" (Patty (5th, 2001)), although it is not a datum of 4-hour exposure. Moreover, since there are descriptions, ""It has skin irritation"" (Patty (5th, 2001, ICSC (2005)), ""burns in the skin"" and ""stimulating"" (HSDB (2002), it was classified in Category 2, although reversibility is not unknown.
-
-NZ_CCID:
-Skin Irritation
-R-PHRASE: R 38 Irritating to skin.
-Eye Irritation
-RESULT: Irritating to skin, eyes and respiratory system.
-REFERENCE SOURCE: Fire Protection Guide to Hazardous Materials. 12 ed. Quincy, MA: National Fire Protection Association, 1997., p. 49-129. ** PEER REVIEWED ** [HSDB]",,"JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",4,CCCCN(CCCC)CCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J35.156C,J-GLOBAL,CCCCN(CCCC)CCCC,Train,1,2702,training
-"NZ_CCID:
-1,3-Propanediamine, N,N-dibutyl-","NZ_CCID:
-3-(dibutylamino)propylamine, N,N-Dibutyltrimethylenediamine",102-83-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1488968B-4C6F-4352-80AF-BAF66DCAEBC4,"NZ_CCID:
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCCCN(CCCC)CCCN,https://pubchem.ncbi.nlm.nih.gov/compound/1626,PubChem,CCCCN(CCCC)CCCN,Train,1,2702,training
-"AU_HCIS:
-1-Dodecanamine, N,N-didodecyl-
-
-NZ_CCID:
-Tridodecylamine",,102-87-4,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5199
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/94B6DA81-BA2F-465C-8B72-EFB2BCBE5883","NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,"AU_HCIS, NZ_CCID",2,CCCCCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/7624,PubChem,CCCCCCCCCCCCN(CCCCCCCCCCCC)CCCCCCCCCCCC,Train,1,2702,training
-"EU_REACH:
-2,5-bis[(4-methylphenyl)amino]benzene-1,4-dicarboxylic acid",,10291-28-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1193/7/4/2/?documentUUID=4a085628-d10d-4a1c-b919-26de70af3ca3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)NC2=CC(=C(C=C2C(=O)O)NC3=CC=C(C=C3)C)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/82524,PubChem,Cc1ccc(Nc2cc(C(=O)O)c(Nc3ccc(C)cc3)cc2C(=O)O)cc1,Train,1,2702,training
-"NZ_CCID:
-Cinnamoyl chloride",,102-92-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/74852718-6C89-4F9C-976B-70BC0574D6CA,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C(C=C1)/C=C/C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/5354261,PubChem,O=C(Cl)/C=C/c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-Benzene, (2-nitroethenyl)-",,102-96-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/ED854014-FEA5-4B91-B02F-37CF06D5D28A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)/C=C/[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/5284459,PubChem,O=[N+]([O-])/C=C/c1ccccc1,Train,1,2702,training
-"EU_REACH:
-2,2-dimethyl-3-oxopropyl dodecanoate",,102985-93-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8619/7/4/2/?documentUUID=872fe893-ed81-4b5e-85ea-acb7079ebadc,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCC(=O)OCC(C)(C)C=O,https://pubchem.ncbi.nlm.nih.gov/compound/23105499,PubChem,CCCCCCCCCCCC(=O)OCC(C)(C)C=O,Train,1,2702,training
-"EU_REACH:
-3-(hexyloxy)propane-1,2-diol",,10305-38-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32155/7/4/2/?documentUUID=ec0541ef-8a35-4062-a90f-2edc9ab632f4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCOCC(CO)O,https://pubchem.ncbi.nlm.nih.gov/compound/11229094,PubChem,CCCCCCOCC(O)CO,Train,1,2702,training
-"EU_REACH:
-2-ethylhexyl acetate",,103-09-3,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16078/7/4/2/?documentUUID=2e9f601d-5f28-48fc-8869-3a31bab883b1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/7635,PubChem,CCCCC(CC)COC(C)=O,Train,1,2702,training
-"AU_HCIS:
-2-ethylhexyl acrylate
-
-JP_CHRIP:
-2-ethylhexyl acrylate
-
-NZ_CCID:
-2-Propenoic acid, 2-ethylhexyl ester","AU_HCIS:
-2-Propenoic acid, 2-ethylhexyl ester
-
-JP_CHRIP:
-2-Ethylhexyl 2-propenoate
-2-Propenoic acid, 2-ethylhexyl ester
-Acrylic acid, 2-ethylhexyl ester
-Octyl acrylate
-
-NZ_CCID:
-2-Ethylhexyl acrylate, Acrylic acid, 2-ethylhexyl ester",103-11-7,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=2002
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2022e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/907C0526-3933-4E39-B29F-9040CF167306","JP_CHRIP:
-[Rationale for the Classification]
-It was classified in Category 2 from (1) - (5).
-
-[Evidence Data]
-(1) In a skin irritation test with rabbits (4-hour occlusive application) similar to OECD and EU test guidelines, all the animals exhibited severe erythema and edema, and the mean score at 24 and 72 hours after application for erythema and edema was 3.2/2.7, 2.7/1.2, respectively. And score 4 and superficial chemical burns were shown in 1/6 animals after 3 days after application (EURAR (2005), AICIS IMAP (2014), GESTIS (Access on April 2020)).
-(2) In a skin irritation test according to US Federal Register Guideline (1964) by 24-hour occlusive application of this substance to intact and abraded skin of rabbits, all the animals showed severe erythema and edema, and the mean score at 24 and 72 hours for erythema and edema for intact skin was 1.75/2 and 3.25/3.25, respectively. Besides, no necrotic effects were observed in intact or abraded skin (EURAR (2005)).
-(3) In an in vitro skin corrosion test using reconstituted human epidermis model (EpiDerm), viability after 3 minutes and 60 minutes of exposure was 99% and 104%, respectively, and it was judged as not corrosive (EURAR (2005), REACH registration dossier (Access on June 2020)).
-(4) This substance caused severe irritation near corrosion after application to the skin of animals, but eye irritation was less severe (SIAP (2004)).
-(5) This substance is a severe skin and eye irritant (HSDB (Access on April 2020)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Mild (500mg dose)
-REFERENCE SOURCE: H&S:2-ETHYLHEXYL ACRYLATE 103-11-7.
-[NTP]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Irritating
-REFERENCE SOURCE: (107) Carpenter D.P. und Smyth H.F.: Am. J. Ophthalmol., 29,1363-1372, (1946) zitiert im BUA-Bericht (1991) [IUCLID 2000]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CCCCC(CC)COC(=O)C=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.601C,J-GLOBAL,C=CC(=O)OCC(CC)CCCC,Train,1,2702,training
-"NZ_CCID:
-Ethyl cinnamate","NZ_CCID:
-Cinnamic acid, ethyl ester",103-36-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/13F046A8-3BF2-4F2B-8D0B-253E489F6F9F,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,CCOC(=O)/C=C/C1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/637758,PubChem,CCOC(=O)/C=C/c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-Dibenzylamine",,103-49-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9372915B-88A6-4308-B616-32752716FDD6,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)CNCC2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/7656,PubChem,c1ccc(CNCc2ccccc2)cc1,Train,1,2702,training
-"NZ_CCID:
-(4-Pyridylthio) acetic acid","NZ_CCID:
-(4-pyridylthio)acetic acid",10351-19-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EEAAD944-14BB-4F6F-9DA4-C008C19F6358,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CN=CC=C1SCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/82574,PubChem,O=C(O)CSc1ccncc1,Train,1,2702,training
-"JP_CHRIP:
-2-Phenoxyethyl isobutyrate",,103-60-6,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0061e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified as ""Not classified"" from (1).
-
-[Evidence Data]
-(1) It is reported that in a skin irritation test with rabbits (n = 8) (equivalent to OECD TG 404, semi-occlusive, 4-hour application, 72-hour observation), slight erythema in 2 animals and slight erythema and edema in 2 were observed after 24 hours, and slight erythema in 1 and slight erythema and edema in 2 persisted after 72 hours (erythema/eschar score: 0/1/0.3/0/0/0/1/1, edema score: 0/0/0/0/0/0/1/1.3) (REACH registration dossier (Accessed Oct. 2020)).",Provided,JP_CHRIP,1,CC(C)C(=O)OCCOc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J182.167I,J-GLOBAL,CC(C)C(=O)OCCOc1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-(2-Bromoethyl)benzene",,103-63-9,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0194e.html,"JP_CHRIP:
-The substance was classified as ""Not classified"" based on the document that 24-hour application of 0.5 mL of the undiluted substance to rabbit skin (OECD TG 404, GLP-compliant) did not cause erythema nor edema during the observation period, and the primary skin irritation index value (PII) was 0 (ECETOC 66 (1995)).",Provided,JP_CHRIP,1,BrCCc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J44.198H,J-GLOBAL,BrCCc1ccccc1,Train,1,2702,training
-"NZ_CCID:
-Benzyl(methyl)amine","NZ_CCID:
-N-Methylbenzylamine",103-67-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AD5973D1-4BAC-446B-B0B0-510780F27AED,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CNCC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/7669,PubChem,CNCc1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-N-Ethylaniline","JP_CHRIP:
-Anilinoethane
-N-Ethylaniline
-N-Ethylbenzenamine
-N-Ethylphenylamine",103-69-5,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0317e.html,"JP_CHRIP:
-Based on the description of the human health effects (ICSC (J) (2001)): ""Redness and pain"" (though the severity of the effects are unknown). Although the substance can be included in Category 2 or 3, it is classified as Category 2 from the viewpoint of safety.",,JP_CHRIP,1,CCNc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.603J,J-GLOBAL,CCNc1ccccc1,Train,1,2702,training
-"NZ_CCID:
-Phenyl isocyanate",,103-71-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/175F266D-2B3A-4652-8254-B55A79F093A1,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)N=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/7672,PubChem,O=C=Nc1ccccc1,Train,1,2702,training
-"NZ_CCID:
-2-(1-Piperazinyl) ethanol","NZ_CCID:
-1-(2-hydroxyethyl)piperazine",103-76-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/87D67303-FC6F-40CA-83BE-94838AB1DBFF,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 41 [Company Data]",,NZ_CCID,1,C1CN(CCN1)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/7677,PubChem,OCCN1CCNCC1,Train,1,2702,training
-"NZ_CCID:
-Phenylacetyl chloride",,103-80-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7D5F0720-8E56-45E6-89A6-FE826D59A6F2,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)CC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7679,PubChem,O=C(Cl)Cc1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-benzyldimethylamine
-
-NZ_CCID:
-Benzyldimethylamine","JP_CHRIP:
-Benzyl-N,N-dimethylamine
-Dimethylbenzylamine
-N,N-Dimethylbenzenemethanamine
-N,N-dimethylbenzylamine
-N-(Phenylmethyl)dimethylamine
-N-Benzyldimethylamine
-
-NZ_CCID:
-N,N-dimethylbenzylamine",103-83-3,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0154e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/96BB6924-95D1-488D-9E7C-2C7D0F74F932","JP_CHRIP:
-Draize tests using rabbits gave score 4 or higher in response to the test substance, indicating that it is severely irritating (ECETOC TR 66 (1995)). Thus, it was classified into Category 1. It is rated as R34 in the EU classification.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CN(C)Cc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J36.099F,J-GLOBAL,CN(C)Cc1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-Acetanilide",,103-84-4,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0010e.html,"JP_CHRIP:
-It was classified as ""Not classified"" because it was not irritating in a skin irritation test with rabbits (OECD TG404, GLP-compliant) (SIDS (2001)).",Provided,JP_CHRIP,1,CC(=O)Nc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.023A,J-GLOBAL,CC(=O)Nc1ccccc1,Train,1,2702,training
-"US_HSDB:
-ACETAMINOPHEN",,103-90-2,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/3001,,,US_HSDB,1,CC(=O)NC1=CC=C(C=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/1983,PubChem,CC(=O)Nc1ccc(O)cc1,Train,1,2702,training
-"JP_CHRIP:
-3-p-cumenyl-2-methylpropionaldehyde",,103-95-7,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0006e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified in Category 2 from (1), (2).
-
-[Evidence Data]
-(1) It is reported that in a skin irritation test with rabbits (n = 3) (semi-occlusive, 4-hour application, 7-day observation), skin irritation was observed (erythema/eschar score: 2.7/2/2, edema score: 3/3/2.7) (REACH registration dossier (Accessed May 2020)).
-(2) It is reported that in a skin irritation test with rabbits (n = 4) (semi-occlusive, 4-hour application, 7-day observation), skin irritation was seen (erythema/eschar score: 2/2/2/2.7, edema score: 2.7/2.7/2.3/3) (REACH registration dossier (Accessed May 2020)).
-
-[Reference Data, etc.]
-(3) It is reported that in a skin irritation test with rabbits (n = 4) (semi-occlusive, 4-hour application, 7-day observation), skin irritation was found (erythema/eschar score: 2/2/2/2, edema score: 2.3/2.7/2/1.7) (REACH registration dossier (Accessed May 2020)).",,JP_CHRIP,1,CC(Cc1ccc(cc1)C(C)C)C=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.429F,J-GLOBAL,CC(C=O)Cc1ccc(C(C)C)cc1,Train,1,2702,training
-"NZ_CCID:
-4'-Nitroacetanilide",,104-04-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/652C50F0-9995-4D89-903C-9A747576C9C7,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(=O)NC1=CC=C(C=C1)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/7691,PubChem,CC(=O)Nc1ccc([N+](=O)[O-])cc1,Train,1,2702,training
-"EU_CLP:
-4-chlorophenylisocyanate",,104-12-1,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC(=CC=C1N=C=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7693,PubChem,O=C=Nc1ccc(Cl)cc1,Test,1,2702,training
-"EU_CLP:
-p-toluenesulphonic acid (containing a maximum of 5 % H2SO4)",,104-15-4,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC1=CC=C(C=C1)S(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/6101,PubChem,Cc1ccc(S(=O)(=O)O)cc1,Test,1,2702,training
-"EU_REACH:
-dimethyl[2-(4-methylpiperazin-1-yl)ethyl]amine",,104-19-8,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27533/7/4/2/?documentUUID=2e89c95a-ea1b-4b0c-ad29-685dd619899e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN1CCN(CC1)CCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/66908,PubChem,CN(C)CCN1CCN(C)CC1,Train,1,2702,training
-"AU_HCIS:
-Phenol, 4-nonyl-
-
-KR_NCIS:
-Nonylphenols
-
-US_HSDB:
-4-Nonylphenol","KR_NCIS:
-4-Nonylphenol; p-Nonylphenol",104-40-5,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5470
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/5359",,,"AU_HCIS, KR_NCIS, US_HSDB",3,CCCCCCCCCC1=CC=C(C=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/1752,PubChem,CCCCCCCCCc1ccc(O)cc1,Train,1,2702,training
-"EU_CLP:
-2,2-dimethyl 3-methyl-3-butenyl propanoate",,104468-21-5,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(=C)CCOC(=O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/53428828,PubChem,C=C(C)CCOC(=O)C(C)(C)C,Test,1,2702,training
-"NZ_CCID:
-3-Phenylpropyl chloride",,104-52-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D4758525-60E5-41B7-A9C6-DB1229C1CB58,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)CCCCl,https://pubchem.ncbi.nlm.nih.gov/compound/7706,PubChem,ClCCCc1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-2-cyclohexylidene-2-phenylacetonitrile","JP_CHRIP:
-Cyclohexylidene(phenyl)acetonitrile",10461-98-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0020e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified as ""Not classified"" from (1).
-
-[Evidence Data]
-(1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 72-hour observation), no skin irritation was seen (erythema/eschar score: 0/0/0, edema score: 0/0/0) (REACH registration dossier (Accessed Aug. 2020)).",Provided,JP_CHRIP,1,N#CC(=C1CCCCC1)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.470.173E,J-GLOBAL,N#CC(=C1CCCCC1)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-1,4-Undecanolide",,104-67-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BEA5B9F3-B8DE-41FD-A15C-3B7D2755BC21,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]",,NZ_CCID,1,CCCCCCCC1CCC(=O)O1,https://pubchem.ncbi.nlm.nih.gov/compound/7714,PubChem,CCCCCCCC1CCC(=O)O1,Train,1,2702,training
-"JP_CHRIP:
-2-Cyclohexylbiphenyl",,10470-01-6,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0758e.html,"JP_CHRIP:
-Based on the statement of ""moderately irritating"" on rabbit test (ACGIH (2001), IUCLID (2000)), it was classified as Category 2.",,JP_CHRIP,1,C1CCC(CC1)c1ccccc1c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.655.576B,J-GLOBAL,c1ccc(-c2ccccc2C2CCCCC2)cc1,Train,1,2702,training
-"EU_REACH:
-2-ethylhexylamine
-
-JP_CHRIP:
-2-Ethylhexylamine
-
-NZ_CCID:
-1-Hexanamine, 2-ethyl-","NZ_CCID:
-2-Ethylhexylamine",104-75-6,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1994/7/4/2/?documentUUID=8e9eab31-ed59-447a-b936-534c742b0456
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0138e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/63C77C25-D16E-4CC0-8174-08EC7CD96CA2","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-Based on a report that the substance is corrosive solution (PATTY (5th, 2001)), the substance was classified into Category 1. As relevant information, there is a result of ""severe"" irritating in a Draize test with rabbits (24-hour application) (RTECS (1997)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Severe
-REFERENCE SOURCE: Prehled Prumyslove Toxikologie; Organicke Latky, Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 (-,436,1986).
-[RTECS]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Severe
-REFERENCE SOURCE: Prehled Prumyslove Toxikologie; Organicke Latky, Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 (-,436,1986).
-[RTECS]",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,CCCCC(CC)CN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J47.019H,J-GLOBAL,CCCCC(CC)CN,Train,1,2702,training
-"EU_REACH:
-1-({bis[(1-chloropropan-2-yl)oxy]phosphoryl}oxy)-2-[({bis[(1-chloropropan-2-yl)oxy]phosphoryl}oxy)methyl]-3-chloro-2-(chloromethyl)propane",,1047637-37-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7660/7/4/2/?documentUUID=063917c3-d1a6-4ddb-a0aa-bc09219c83e4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CCl)OP(=O)(OCC(COP(=O)(OC(C)CCl)OC(C)CCl)(CCl)CCl)OC(C)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/138395011,PubChem,CC(CCl)OP(=O)(OCC(CCl)(CCl)COP(=O)(OC(C)CCl)OC(C)CCl)OC(C)CCl,Train,1,2702,training
-"JP_CHRIP:
-3-(Diethylamino)propylamine
-
-NZ_CCID:
-3-Diethylamino-1-propylamine",,104-78-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0147e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/56A470ED-951E-44BD-85A5-D85DCCE53A67","JP_CHRIP:
-In a skin irritation test where 0.5 mL of the substance was applied to one rabbit for 4-hour, necrosis was observed 1-hour after application (ECETOC TR66 (1995)). Additionally, the substance has a pH of 11.7 (20 degC, 10 g/L water) (GESTIS (access on Oct. 2009)) and is classified into C; R34 in EU classification. Therefore, the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CCN(CC)CCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J35.461I,J-GLOBAL,CCN(CC)CCCN,Train,1,2702,training
-"EU_CLP:
-tetrahydrofuran-2,5-diyldimethanol",,104-80-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1CC(OC1CO)CO,https://pubchem.ncbi.nlm.nih.gov/compound/97792,PubChem,OCC1CCC(CO)O1,Test,1,2702,training
-"NZ_CCID:
-4-Methylbenzyl chloride",,104-82-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3D8FE309-1B27-46A2-942D-BF9501BBB3B8,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=CC=C(C=C1)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/7722,PubChem,Cc1ccc(CCl)cc1,Train,1,2702,training
-"NZ_CCID:
-4-Tolunitrile","NZ_CCID:
-p-Tolunitrile",104-85-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BA466070-0111-4BA8-BF5F-C532F3C3D133,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=CC=C(C=C1)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/7724,PubChem,Cc1ccc(C#N)cc1,Train,1,2702,training
-"NZ_CCID:
-Benzenemethanamine, 4-chloro-",,104-86-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3E66A74E-44E0-4388-B209-23CC9C4FD9C7,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC(=CC=C1CN)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/66036,PubChem,NCc1ccc(Cl)cc1,Train,1,2702,training
-"JP_CHRIP:
-p-Tolylaldehyde","JP_CHRIP:
-4-methylbenzaldehyde",104-87-0,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0035e.html,"JP_CHRIP:
-In the rabbit test, moderate irritation was reported (PATTY, 5th (2001)). And in guinea pig test, occlusive exposure of the substance for 24 hours caused moderate irritation with edema, erythema, and scattered necrosis (HSDB (2009)). Based on these documents, the substance was classified as Category 2.",,JP_CHRIP,1,Cc1ccc(C=O)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.036I,J-GLOBAL,Cc1ccc(C=O)cc1,Train,1,2702,training
-"NZ_CCID:
-Crotonoyl chloride (mixture of cis- and trans isomers)","NZ_CCID:
-crotonyl chloride",10487-71-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/46B727BC-8505-4B87-8905-84EC7B9CAF41,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C/C=C/C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/643131,PubChem,C/C=C/C(=O)Cl,Train,1,2702,training
-"JP_CHRIP:
-p-Chlorobenzaldehyde
-
-NZ_CCID:
-4-Chlorobenzaldehyde",,104-88-1,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0187e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5E881681-B578-4D46-9B3A-FCD3ECC1518D","JP_CHRIP:
-The substance was classified as Category 2 based on the documented case of ""highly irritating"" (IUCLID (2000)) resulted from the rabbit test (Federal Regulations, Title 16, Section 1500.41). As relevant information, in other rabbit test, the substance was evaluated as slightly irritating, or reversible irritating effects (IUCLID (2000)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,"JP_CHRIP, NZ_CCID",2,Clc1ccc(C=O)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J96.206F,J-GLOBAL,O=Cc1ccc(Cl)cc1,Train,1,2702,training
-"NZ_CCID:
-3-Cyclopentyl propionyl chloride",,104-97-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3B33B989-C9DF-42E6-B4DF-8E6FE2633ACD,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CCC(C1)CCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/66039,PubChem,O=C(Cl)CCC1CCCC1,Train,1,2702,training
-"NZ_CCID:
-2-Propenoic acid, 3-(1H-imidazol-4-yl)-",,104-98-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C5F16FDC-8971-46AC-8E6A-5D9CACB68712,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,C1=C(NC=N1)/C=C/C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/736715,PubChem,O=C(O)/C=C/c1cnc[nH]1,Train,1,2702,training
-"JP_CHRIP:
-1,4-Diethylbenzene
-
-NZ_CCID:
-1,4-Diethylbenzene","JP_CHRIP:
-1,4-diethylbenzene
-Benzene, 1,4-diethyl-
-m-(or p-)diethylbenzene",105-05-5,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0124e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5D57A41B-290A-4EEF-8296-D75DB39766F3","JP_CHRIP:
-Based on a result of ""moderate irritation and slight necrosis"" by application of undiluted substance to rabbits (PATTY (5th, 2001)), the substance was classified into Category 2. As relevant information, there is a report of skin injury from contact as human health effects (HSDB (2003)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CCc1ccc(CC)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J43.478G,J-GLOBAL,CCc1ccc(CC)cc1,Train,1,2702,training
-"JP_CHRIP:
-p-Divinylbenzene","JP_CHRIP:
-1,4-Diethenylbenzene
-divinylbenzene
-m-(or p-)divinylbenzene
-p-Divinylbenzene",105-06-6,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2099e.html,"JP_CHRIP:
-[Rationale for the Classification]
-Based on (1), it was classified in Category 2. Besides, since no data for each isomer were available, this substance was classified in accordance with the data on the isomeric mixture.
-
-[Evidence Data]
-(1) An isomeric mixture of this substance is moderately irritating to the eyes and skin (PATTY (6th, 2012)).
-
-[Reference Data, etc.]
-(2) It was classified as ""Skin Irrit. 2 (H315)"" in the EU-CLP classification (EU CLP classification (Access on November 2019)).",,JP_CHRIP,1,C=Cc1ccc(C=C)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J91.290E,J-GLOBAL,C=Cc1ccc(C=C)cc1,Train,1,2702,training
-"EU_REACH:
-cyclohexane-1,4-diyldimethanol",,105-08-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14211/7/4/2/?documentUUID=07fb6645-1229-4b75-9812-3f61256ee806,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC(CCC1CO)CO,https://pubchem.ncbi.nlm.nih.gov/compound/7735,PubChem,OCC1CCC(CO)CC1,Train,1,2702,training
-"EU_REACH:
-3-{[4'-(3-aminophenoxy)-[1,1'-biphenyl]-4-yl]oxy}aniline",,105112-76-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1388/7/4/2/?documentUUID=73e9bfac-1b2e-4d5b-867b-8e6706087cd1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC(=C1)OC2=CC=C(C=C2)C3=CC=C(C=C3)OC4=CC=CC(=C4)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/11810717,PubChem,Nc1cccc(Oc2ccc(-c3ccc(Oc4cccc(N)c4)cc3)cc2)c1,Train,1,2702,training
-"EU_CLP:
-2-diethylaminoethyl methacrylate",,105-16-8,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCN(CC)CCOC(=O)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/61012,PubChem,C=C(C)C(=O)OCCN(CC)CC,Test,1,2702,training
-"EU_CLP:
-3-(bis(2-ethylhexyl)aminomethyl)benzothiazole-2(3H)-thione",,105254-85-1,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCCCC(CC)CN(CC(CC)CCCC)CN1C2=CC=CC=C2SC1=S,https://pubchem.ncbi.nlm.nih.gov/compound/176005,PubChem,CCCCC(CC)CN(CC(CC)CCCC)Cn1c(=S)sc2ccccc21,Test,1,2702,training
-"EU_REACH:
-4-cyclohexylbutan-2-ol",,10528-67-3,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18777/7/4/2/?documentUUID=d1cf4598-4ae5-4bb2-a9f5-36d76858f64a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CCC1CCCCC1)O,https://pubchem.ncbi.nlm.nih.gov/compound/112065,PubChem,CC(O)CCC1CCCCC1,Train,1,2702,training
-"JP_CHRIP:
-Vinyl propionate",,105-38-4,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0016e.html,"JP_CHRIP:
-On the basis of results as ""irritating"" in two tests in which it was applied to rabbit skins, it was classified in Category 2.
-Besides, ""not irritating"" from an irritation score of 2/10 is reported in another test (IUCLID (2000)).",,JP_CHRIP,1,CCC(=O)OC=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J36.594G,J-GLOBAL,C=COC(=O)CC,Train,1,2702,training
-"NZ_CCID:
-3-Methylpentanoic acid","NZ_CCID:
-3-methylvaleric acid",105-43-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/97F0DCB2-4890-4531-8142-E30A136DF299,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCC(C)CC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7755,PubChem,CCC(C)CC(=O)O,Train,1,2702,training
-"EU_REACH:
-N,N'-ethylenebis[N-acetylacetamide]",,10543-57-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14315/7/4/2/?documentUUID=8104f264-d73d-4696-b31c-35ee1dac4b0f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)N(CCN(C(=O)C)C(=O)C)C(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/66347,PubChem,CC(=O)N(CCN(C(C)=O)C(C)=O)C(C)=O,Train,1,2702,training
-"JP_CHRIP:
-methyl acetoacetate","JP_CHRIP:
-Methyl 3-oxobutyrate
-1-Methoxybutane-1,3-dione
-Acetoacetic acid methyl ester
-Butanoic acid, 3-oxo-, methyl ester
-methyl acetoacetate",105-45-3,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0155e.html,"JP_CHRIP:
-Rabbit tests (OECD TG 404, GLP) (IUCLID, 2000) found that the substance is not irritating. Based on this description, it was classified into the ""Not classified"" category.",Provided,JP_CHRIP,1,COC(=O)CC(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J45.957G,J-GLOBAL,COC(=O)CC(C)=O,Train,1,2702,training
-"JP_CHRIP:
-sec-Butyl acetate","JP_CHRIP:
-1-Methylpropyl acetate
-Acetic acid, 1-methylpropyl ester
-Acetic acid, 2-butyl ester",105-46-4,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2090e.html,"JP_CHRIP:
-Based on a description that this substance is irritating to the skin (HSDB (Access on August 2017)), it was classified in Category 2. The category was changed from the previous classification due to the revision of the GHS classification guidance for the Japanese Government.",,JP_CHRIP,1,CCC(C)OC(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.030D,J-GLOBAL,CCC(C)OC(C)=O,Train,1,2702,training
-"JP_CHRIP:
-Ethyl butanoate
-
-US_HSDB:
-ETHYL N-BUTYRATE",,105-54-4,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0088e.html
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/406","JP_CHRIP:
-Based on a report of ""irritating to skin"" (HSDB (2002)), the substance was classified into Category 2. As relevant information, there is a report that 5% in petrolatumin produced no irritation after a 48 hr closed-patch test in 25 human subjects (HSDB (2002)).",,"JP_CHRIP, US_HSDB",2,CCCC(=O)OCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.235B,J-GLOBAL,CCCC(=O)OCC,Train,1,2702,training
-"EU_REACH:
-1,3-diethyl-2-thiourea",,105-55-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12736/7/4/2/?documentUUID=54c4520f-e443-4771-b25f-89adf4439c0b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCNC(=S)NCC,https://pubchem.ncbi.nlm.nih.gov/compound/2735009,PubChem,CCNC(=S)NCC,Train,1,2702,training
-"EU_REACH:
-ethyl 2-cyanoacetate",,105-56-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14515/7/4/2/?documentUUID=e05e38f5-d9d5-4efd-bf56-ae46a1b98cc5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CC#N,https://pubchem.ncbi.nlm.nih.gov/compound/7764,PubChem,CCOC(=O)CC#N,Train,1,2702,training
-"JP_CHRIP:
-epsilon-Caprolactam
-
-NZ_CCID:
-Caprolactam","JP_CHRIP:
-Aminocaproic lactam
-Caprolactam
-epsilon-Caprolactam
-Hexahydro-2H-azepin-2-one
-Hexano-6-lactam
-
-NZ_CCID:
-1-Aza-2-cycloheptanone, 2-Azacycloheptanone, 2-Ketohexamethylenimine, 2-Oxohexamethyleneimine, 2-Oxohexamethylenimine, 2-Perhydroazepinone, 2H-Azepin-2-one, hexahydro-, 6-Caprolactam, 6-Hexanelactam, Aminocaproic lactam, Hexahydro-2-azepinone, Hexahydro-2H-azepin-2-one, Hexanoic acid, 6-amino-, cyclic lactam, Hexanolactam",105-60-2,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2040e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B4C2EDD6-9006-41BE-A257-C46718CA20AB","JP_CHRIP:
-Based on a description that this substance is a skin irritant (DFGOT Vol. 4 (1992)), and a report that it is slightly irritating in a skin irritation test with rabbits (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)), it was classified in Category 2. Besides, this substance was classified as ""Skin Irrit. 2"" in EU CLP classification (ECHA CL Inventory (Access on June 2017)). Based on the information obtained in this investigation, the category was revised.
-
-NZ_CCID:
-Skin Irritation
-R-PHRASE: R 38 Irritating to skin. [N-Class]
-Eye Irritation
-R-PHRASE: R 36 Irritating to eyes. [N-Class]",,"JP_CHRIP, NZ_CCID",2,O=C1CCCCCN1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.605F,J-GLOBAL,O=C1CCCCCN1,Train,1,2702,training
-"KR_NCIS:
-N,N'-Bis(3-aminopropyl)-1,2-ethane diamin","KR_NCIS:
-1,3-Propanediamine, N,N''-1,2-ethanediylbis; 1,3-Propanediamine, N,N''-1,2-ethanediylbis-; 1,3-Propanediamine, N,N''-ethylenebis-; 1,3-Propanediamine, N1,N1'-1,2-ethanediylbis-; N-(2-(3-Aminopropylamino)ethyl)-1,3-propanediamine; N,N'-Bis(3-aminopropyl)-1,2-ethanediamine; N,N'-Bis(3-aminopropyl)diaminoethane; N,N'-Bis(3-aminopropyl)ethylenediamine; N,N'-Diaminopropylethylenediamine; N-[2-(3-Aminopropylamino)ethyl]propane-1,3-diamine",10563-26-5,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C(CN)CNCCNCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/25378,PubChem,NCCCNCCNCCCN,Train,1,2702,training
-"EU_REACH:
-{3-[(3-aminopropyl)amino]propyl}dimethylamine",,10563-29-8,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12651/7/4/2/?documentUUID=eefcc885-0e68-4f02-a55d-c6eade158cf9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C)CCCNCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/82728,PubChem,CN(C)CCCNCCCN,Train,1,2702,training
-"JP_CHRIP:
-Diisopropyl peroxydicarbonate","JP_CHRIP:
-Peroxydicarbonic acid, bis(1-methylethyl) ester",105-64-6,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0163e.html,"JP_CHRIP:
-The substance was classified as Category 2 based on the documented case of ""moderate irritation"" (DFGMAK-Doc 3 (1992)) resulted from the test in which the undiluted substance was applied to rabbits.",,JP_CHRIP,1,CC(C)OC(=O)OOC(=O)OC(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J9.269J,J-GLOBAL,CC(C)OC(=O)OOC(=O)OC(C)C,Train,1,2702,training
-"JP_CHRIP:
-2,4-Xylenol
-
-KR_NCIS:
-2,4-Dimethylphenol
-
-NZ_CCID:
-2,4-Xylenol","JP_CHRIP:
-2,4-Xylenol
-Phenol, 2,4-dimethyl-
-
-KR_NCIS:
-1-Hydroxy-2,4-dimethylbenzene; 2,4-Xylenol; 4,6-Dimethylphenol; 4-Hydroxy-1,3-dimethylbenzene; m-Xylenol; Phenol, 2,4-dimethyl-
-
-NZ_CCID:
-1-Hydroxy-2,4-dimethylbenzene, Phenol, 2,4-dimethyl-, m-Xylenol",105-67-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-meti-0025e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1482CCF7-1FF3-4030-A317-B48A7FF08DC5","JP_CHRIP:
-Because it is reported that in a skin irritation test with rabbits, corrosive action was observed on application of this substance (EPA Pesticide RED (1994)), and it is described in multiple pieces of literature that this substance is corrosive to the skin (Environmental Risk Assessment for Chemical Substances Vol.5 (Ministry of the Environment, 2006), EPA Pesticide Fact Sheet (1994)), the substance was classified in Category 1. In addition, this substance was classified as ""Skin. Corr. 1B H314"" in the EU CLP classification (ECHA CL Inventory (Access on October 2015)).
-
-NZ_CCID:
-Skin Irritation
-R-PHRASE: R 34 Causes burns. [N-CLASS]
-Eye Irritation
-EXPERT JUDGEMENT: Assume it will be as corrosive to eyes as it is corrosive to skin.",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,Cc1ccc(O)c(C)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.606D,J-GLOBAL,Cc1ccc(O)c(C)c1,Train,1,2702,training
-"EU_REACH:
-dodecanoyl dodecaneperoxoate
-
-JP_CHRIP:
-dilauroyl peroxide","JP_CHRIP:
-bis(1-Oxododecyl)peroxide
-didodecanoyl peroxide
-Lauroyl peroxide
-Peroxide, bis(1-oxododecyl)
-Peroxide, didodecanoyl",105-74-8,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2224/7/4/2/?documentUUID=b567389c-23c7-4a9f-9b72-98962fb7ee46
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0156e.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-Since rabbit tests found that the substance causes no irritation (DFGOT vol. 3 (1992)), it was classified into the ""Not classified"" category.",Provided,"EU_REACH, JP_CHRIP",2,CCCCCCCCCCCC(=O)OOC(=O)CCCCCCCCCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.853C,J-GLOBAL,CCCCCCCCCCCC(=O)OOC(=O)CCCCCCCCCCC,Train,1,2702,training
-"EU_REACH:
-dibutyl but-2-enedioate",,105-75-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2056/7/4/2/?documentUUID=d48e8f07-c579-49cd-8ee4-64fc4828e864,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOC(=O)/C=C/C(=O)OCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/5271570,PubChem,CCCCOC(=O)/C=C/C(=O)OCCCC,Train,1,2702,training
-"JP_CHRIP:
-1-(6-Chloro-3-pyridylmethyl)-N-nitroimidazolidin-2-ylidenamine; Imidacloprid",,105827-78-9,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2074e.html,"JP_CHRIP:
-[Rationale for the Classification]
-Based on (1), it was classified as ""Not classified.""
-
-[Evidence Data]
-(1) The mean scores at 24/48/72 hours were all 0 in a skin irritation test with rabbits according to OECD TG 404, and it was concluded to be non-irritating (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2013), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2016)).",Provided,JP_CHRIP,1,[O-][N+](=O)N=C1NCCN1Cc1ccc(Cl)nc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J452.024F,J-GLOBAL,O=[N+]([O-])N=C1NCCN1Cc1ccc(Cl)nc1,Train,1,2702,training
-"EU_CLP:
-2-chloro-5-chloromethylthiazole",,105827-91-6,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=C(SC(=N1)Cl)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/2763179,PubChem,ClCc1cnc(Cl)s1,Test,1,2702,training
-"NZ_CCID:
-1,3-Propanediamine, N-(3-aminopropyl)-N-methyl-","NZ_CCID:
-N,N-Bis(3-aminopropyl) methylamine",105-83-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EB33CDC0-B5F4-49D8-BBA7-7F0A09C8FE22,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [ECB]
-Eye Irritation
-R PHRASE: R 34 [ECB]",,NZ_CCID,1,CN(CCCN)CCCN,https://pubchem.ncbi.nlm.nih.gov/compound/7777,PubChem,CN(CCCN)CCCN,Train,1,2702,training
-"EU_REACH:
-2-phenoxyethyl methacrylate",,10595-06-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21714/7/4/2/?documentUUID=c0f6ce93-ace5-4a47-a9ea-ab8c9cf633dc,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OCCOC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/66357,PubChem,C=C(C)C(=O)OCCOc1ccccc1,Train,1,2702,training
-"EU_REACH:
-1,4-dioxacycloheptadecane-5,17-dione",,105-95-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14715/7/4/2/?documentUUID=34a46e3c-ed96-4d8f-a5d9-15902b4451fd,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CCCCCC(=O)OCCOC(=O)CCCCC1,https://pubchem.ncbi.nlm.nih.gov/compound/61014,PubChem,O=C1CCCCCCCCCCCC(=O)OCCO1,Train,1,2702,training
-"EU_REACH:
-1-oxacyclohexadecan-2-one",,106-02-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5937/7/4/2/?documentUUID=c7079faa-1c96-4f65-a564-eb79b91dcbb9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CCCCCCCOC(=O)CCCCCC1,https://pubchem.ncbi.nlm.nih.gov/compound/235414,PubChem,O=C1CCCCCCCCCCCCCCO1,Train,1,2702,training
-"EU_REACH:
-carbendazim
-
-JP_CHRIP:
-carbendazim(ISO)","JP_CHRIP:
-1H-Benzimidazol-2-ylcarbamic acid methyl ester
-1H-Benzimidazole-2-carbamic acid, methyl ester
-2-methoxycarbonylamino-benzimidazole
-Carbamic acid, 1H-benzimidazol-2-yl-, methyl ester
-Carbendazim
-Carbendazol
-Methyl (1H-benzimidazol-2-yl)carbamate
-methyl benzimidazole-2-yl-carbamate
-Methyl benzimidazole-2-ylcarbamate",10605-21-7,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27856/7/4/2/?documentUUID=48616375-3c22-4a1f-b4ca-26f7a4d9aae2
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/07-meti-0015e.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-Since EHC149 (1993) states, ""There is no skin irritation, because no irritation was observed in all of the 4 hour applications of 2.5g to rabbits in 4, 24, 48 and 72 hours,"" it was classified into ""Not classified"".",Provided,"EU_REACH, JP_CHRIP",2,COC(=O)Nc1nc2ccccc2[nH]1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.120H,J-GLOBAL,COC(=O)Nc1nc2ccccc2[nH]1,Train,1,2702,training
-"KR_NCIS:
-Bis(2-ethylhexyl)amine
-
-NZ_CCID:
-Bis(2-ethylhexyl) amine","KR_NCIS:
-1-Hexanamine, 2-ethyl-N-(2-ethylhexyl)-; 2,2'-Diethyldihexylamine; 2-Ethyl-N-(2-ethylhexyl)hexan-1-amine; Bis(2-ethylhexyl)amine; Di(2-ethylhexyl)amine; Di-(2-Ethylhexyl)-amine; Di-2-ethylhexylamine; Dihexylamine, 2,2'-diethyl-; N,N-Bis(2-ethylhexyl)amine
-
-NZ_CCID:
-bis(2-ethylhexyl)amine",106-20-7,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2044B219-353C-469E-AC08-3CB6CA325CB3","NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"KR_NCIS, NZ_CCID",2,CCCCC(CC)CNCC(CC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/7791,PubChem,CCCCC(CC)CNCC(CC)CCCC,Train,1,2702,training
-"NZ_CCID:
-6-Octenal, 3,7-dimethyl-
-
-US_HSDB:
-CITRONELLAL",,106-23-0,Cat 2,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4DB06F5E-3FE1-478F-932F-D4FC38B58688
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/594","NZ_CCID:
-Skin Irritation
-R-PHRASE: R 38. [MERCK]
-Eye Irritation
-EXPERT JUDGEMENT: Classification based on 6.3A. Eyes more sensitive.",,"NZ_CCID, US_HSDB",2,CC(CCC=C(C)C)CC=O,https://pubchem.ncbi.nlm.nih.gov/compound/7794,PubChem,CC(C)=CCCC(C)CC=O,Train,1,2702,training
-"AU_HCIS:
-2,6-Octadien-1-ol, 3,7-dimethyl-, (E)-
-
-JP_CHRIP:
-Geraniol
-
-NZ_CCID:
-Geraniol
-
-US_HSDB:
-GERANIOL","JP_CHRIP:
-3,7-dimethyl-1-hydroxy-2,6-octadiene",106-24-1,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5451
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0076e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5BE63150-66E8-4726-9E15-C5995B83D289
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/484","JP_CHRIP:
-A test in which 0.5 mL of undiluted this substance was applied to rabbits (3 or 4 animals) for 4 hours (OECD TG 404, GLP) was conducted three times, slight to moderate erythema and slight to moderate edema were observed during an observation period (1-7 days), and the primary irritation index (PII) was 3.67, 3.33, 2.92, respectively (ECETOC TR 66 (1995)). Therefore, it was classified in Category 2. Besides, it is reported that this substance was severely irritating at a 32% concentration in a human patch test (HSDB (2007)).
-
-NZ_CCID:
-Skin Irritation
-EXPERT JUDGEMENT: Variable results obtained in studies. Classification based on weight of evidence. See:
-1] (CT01DG 1979). [RTECS]
-2] BUSH BOAKE ALLEN LTD LONDON. [IUCLID 2000]
-3] Motoyoshi K, Toyoshima Y, Sato M, Yoshimura M. Pola Corp., Yokohama, Japan. Cosmet. Toiletries; VOL 94 ISS Aug 1979, P41-48, (REF 4). [TOXLINE]
-Eye Irritation
-REMARK: Classified as 6.4A based on 6.3A skin classification.",Provided,"AU_HCIS, JP_CHRIP, NZ_CCID, US_HSDB",4,CC(=CCC/C(=C/CO)/C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.240I,J-GLOBAL,CC(C)=CCC/C(C)=C/CO,Train,1,2702,training
-"JP_CHRIP:
-Butyric anhydride
-
-NZ_CCID:
-Butyric anhydride",,106-31-0,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0160e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/379EB139-75D2-4CD4-A5C4-83F2450146C8","JP_CHRIP:
-It was described in the human case that the substance caused skin irritation by contact with vapor (HSDB (2002)). And as for the information of n-butyric acid it was reported that in the guinea pig test (occlusive application with 10mg for 24 hours, non-occlusive application with 500mg for 24 hours), severe reactions were observed (PATTY, 5th (2001)). And it was also reported that in the rabbit test (OECD TG404, GLP-compliant), corrosive effects were observed (IUCLID (2000)). Based on these documents, the substance was classified as Category 1.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",Provided,"JP_CHRIP, NZ_CCID",2,CCCC(=O)OC(=O)CCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.050D,J-GLOBAL,CCCC(=O)OC(=O)CCC,Train,1,2702,training
-"NZ_CCID:
-1,4-Dibromobenzene","NZ_CCID:
-p-dibromobenzene",106-37-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/20B93CD2-A7EE-4CEA-B41E-2EE658C19541,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1Br)Br,https://pubchem.ncbi.nlm.nih.gov/compound/7804,PubChem,Brc1ccc(Br)cc1,Train,1,2702,training
-"NZ_CCID:
-4-Bromotoluene",,106-38-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/02FE3750-654C-4249-9B6E-BA9C6B42037D,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=CC=C(C=C1)Br,https://pubchem.ncbi.nlm.nih.gov/compound/7805,PubChem,Cc1ccc(Br)cc1,Train,1,2702,training
-"EU_REACH:
-2,4,8,10-tetra(tert-butyl)-6-hydoroxy-12H-dibenzo[d,g] [1,3,2]dioxaphosphocin, 6-oxide",,106396-29-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/28016/7/4/2/?documentUUID=10b98ccc-93b5-4e4a-ba2c-1bb2e1a9cfad,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1=CC2=C(C(=C1)C(C)(C)C)OP(=O)(OC3=C(C2)C=C(C=C3C(C)(C)C)C(C)(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/174427,PubChem,CC(C)(C)c1cc2c(c(C(C)(C)C)c1)OP(=O)(O)Oc1c(cc(C(C)(C)C)cc1C(C)(C)C)C2,Train,1,2702,training
-"AU_HCIS:
-p-xylene
-
-JP_CHRIP:
-p-Xylene
-
-KR_NCIS:
-p-Xylene
-
-NZ_CCID:
-Benzene, 1,4-dimethyl-
-
-US_HSDB:
-4-XYLENE","AU_HCIS:
-Benzene, 1,4-dimethyl-
-
-JP_CHRIP:
-1,4-Dimethylbenzene
-Benzene, 1,4-dimethyl-
-m-Xylene and p-Xylene
-p-Xylol
-para-Xylene
-Xylene
-Xylenes
-
-KR_NCIS:
-1,4-Dimethylbenzene; 1,4-Xylene; 4-Methyltoluene; Benzene, 1,4-dimethyl-; para-Xylene; p-Xylol; XYLENE, P-; XYLENE, PARA-
-
-NZ_CCID:
-1,4-Dimethylbenzene, p-Dimethylbenzene, p-Methyltoluene, p-Xylene, p-Xylol",106-42-3,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4713
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0084e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0FD6F3CB-5746-4FE9-AA41-6D699E6BFEFB
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/136","JP_CHRIP:
-Based on a report that this substance was irritating in a skin irritation test with rabbits exposed to 0.5 ml of this substance for 4 hours (EHC 190 (1997)), this substance was classified in Category 2. Besides, it is reported that erythema, edema, desquamation, and necrosis were observed, and this substance showed a moderate to severe irritation of the skin in tests in which xylene mixtures containing this substance were applied to rabbit skin (Hazard Assessment Report (CERI, NITE, 2008)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Irritating
-REFERENCE SOURCE: ICI Chemicals & Polymers Limited Runcorn, Cheshire (54) Jacobs G, Martens M, et al. Proposal of limit concentrations for
-Skin Irritation within the context of a new EEC directive on the classification and labelling of preparations. Regulatory Toxicology and Pharmacology 1987. 7. 370-378.[IUCLID 2000]
-REMARK: EC Classification: Irritating
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Application of approximately 0.05 to 0.5 ml of liquid xylenes (individual isomers or undefined composition) to the rabbit eye was reported to cause immediate discomfort and blepharospasm followed by slight conjunctival irritation and very slight, transient corneal necrosis (Wolf et al., 1956). Application of 0.1 ml liquid xylene [not defined) was mildly irritant to rabbit eye. The lesions were not described (Kennah et al., 1989).
-REFERENCE SOURCE: EHC[ INCHEM]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,Cc1ccc(C)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.609I,J-GLOBAL,Cc1ccc(C)cc1,Train,1,2702,training
-"AU_HCIS:
-p-cresol [1]
-
-JP_CHRIP:
-p-Cresol
-
-KR_NCIS:
-4-Methylphenol
-
-NZ_CCID:
-4-Cresol
-
-US_HSDB:
-p-CRESOL","AU_HCIS:
-o-cresol  [2]
-p-cresol  [3]
-mix-cresol [4]
-Phenol, 4-methyl-
-p-cresol
-o-cresol
-mix-cresol
-
-JP_CHRIP:
-4-Hydroxy-1-methylbenzene
-4-Methylphenol
-cresol
-p-cresol
-p-Cresol; 4-Methylphenol
-para-Hydroxytoluene
-Phenol, 4-methyl-
-
-KR_NCIS:
-1-Hydroxy-4-methylbenzene; 1-Methyl-4-hydroxybenzene; 4-Cresol; 4-Hydroxy-1-methylbenzene; 4-Hydroxytoluene; CRESOL, P-; p-Cresol; p-Hydroxytoluene
-
-NZ_CCID:
-p-Cresol",106-44-5,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1068
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2033e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9E52F8E5-0163-4C72-9E07-F0EF50369828
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1814","JP_CHRIP:
-There is a report that after occlusive application of 0.5 mL of the undiluted liquid of this substance for 4 hours to rabbits, corrosivity (2/6 animals) was observed (EHC 168 (1995), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), SIDS (2005)). In another study, there is a report that after application of the undiluted liquid of this substance to rabbits, severe erythema and edema occurred within 24 hours and did not disappear within 72 hours (SIDS (2001)). From the above results, it was classified in Category 1. Besides, this substance was classified in ""C; R34"" in EU DSD classification and in ""Skin Corr. 1B"" in EU CLP classification.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,Cc1ccc(O)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.185A,J-GLOBAL,Cc1ccc(O)cc1,Train,1,2702,training
-"JP_CHRIP:
-4-chlorophenol","JP_CHRIP:
-4-Chloro-1-hydroxybenzene
-4-Chlorophenol
-4-Hydroxychlorobenzene
-4-Monochlorophenol
-p-Chlorophenol",106-48-9,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0031e.html,"JP_CHRIP:
-Since the substance was corrosive in topical application tests using rabbits (ATSDR (1999)), it was classified into Category 1.",,JP_CHRIP,1,Oc1ccc(Cl)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.611K,J-GLOBAL,Oc1ccc(Cl)cc1,Train,1,2702,training
-"NZ_CCID:
-1-Methyl-4-piperidinol","NZ_CCID:
-4-hydroxy-1-methylpiperidine",106-52-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FD014383-5F21-422F-A418-75F5B57310FF,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CN1CCC(CC1)O,https://pubchem.ncbi.nlm.nih.gov/compound/66048,PubChem,CN1CCC(O)CC1,Train,1,2702,training
-"EU_REACH:
-N-(4-{[3-(dimethylamino)propyl]sulfamoyl}phenyl)-2-[(2-methoxy-4-nitrophenyl)diazenyl]-3-oxobutanamide",,1065519-44-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1176/7/4/2/?documentUUID=09306093-c9df-4f98-8c9b-ca7830cd14db,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC=C(C=C1)S(=O)(=O)NCCCN(C)C)N=NC2=C(C=C(C=C2)[N+](=O)[O-])OC,https://pubchem.ncbi.nlm.nih.gov/compound/91997932,PubChem,COc1cc([N+](=O)[O-])ccc1N=NC(C(C)=O)C(=O)Nc1ccc(S(=O)(=O)NCCCN(C)C)cc1,Train,1,2702,training
-"NZ_CCID:
-1,4-Dimethylpiperazine",,106-58-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/37A2C430-87EF-450C-9EBF-C93A919797BE,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CN1CCN(CC1)C,https://pubchem.ncbi.nlm.nih.gov/compound/7818,PubChem,CN1CCN(C)CC1,Train,1,2702,training
-"JP_CHRIP:
-Isobutyl acrylate
-
-NZ_CCID:
-2-Propenoic acid, 2-methylpropyl ester","JP_CHRIP:
-2-Methylpropyl acrylate
-2-Propenoic acid, 2-methylpropyl ester
-
-NZ_CCID:
-Acrylic acid, isobutyl ester, Isobutyl 2-propenoate, Isobutyl acrylate",106-63-8,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0106e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FC814950-F4B3-4AA7-A012-F18ED773210E","JP_CHRIP:
-Based on a result of ""moderate irritating"" in a rabbit skin irritation test (PATTY (5th, 2001)), the substance was classified into Category 2.
-
-NZ_CCID:
-Skin Irritation
-SPECIES:
-RESULT: Prolonged skin or eye contact may result in severe tissue damage.
-REFERENCE SOURCE: Clayton, G.D., F.E. Clayton (eds.) Pattys Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994. 3000. [HSDB]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Mild
-REFERENCE SOURCE: Prehled Prumyslove Toxikologie; Organicke Latky, Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 (-,371,1986).",,"JP_CHRIP, NZ_CCID",2,CC(C)COC(=O)C=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J33.774I,J-GLOBAL,C=CC(=O)OCC(C)C,Train,1,2702,training
-"EU_REACH:
-dimethyl succinate
-
-JP_CHRIP:
-Dimethyl succinate",,106-65-0,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15043/7/4/2/?documentUUID=c01039dd-200a-4016-9398-0745284d5d44
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0077e.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-It was classified as ""Not classified"" because the average irritation score was 0.0 in a test by a 4-hour application to the skin of six rabbits (EPA 40CFR 798.4470, GLP), and there was no irritation (USEPA/HPV (2001)).",Provided,"EU_REACH, JP_CHRIP",2,COC(=O)CCC(=O)OC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.244A,J-GLOBAL,COC(=O)CCC(=O)OC,Train,1,2702,training
-"JP_CHRIP:
-Octan-3-one; Ethyl amyl ketone","JP_CHRIP:
-3-Octanone",106-68-3,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0036e.html,"JP_CHRIP:
-The substance was classified as Category 2 based on the documented case of ""moderate irritation"" resulted from rabbit test under an occlusive condition by a wrap with the undiluted substance (PATTY, 5th (2001)).",,JP_CHRIP,1,CCCCCC(=O)CC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.245J,J-GLOBAL,CCCCCC(=O)CC,Train,1,2702,training
-"EU_REACH:
-methyl hexanoate",,106-70-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5296/7/4/2/?documentUUID=38d53c6f-1ac0-48f8-9589-f03562963f60,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCC(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/7824,PubChem,CCCCCC(=O)OC,Train,1,2702,training
-"JP_CHRIP:
-2,2'-Oxydiethyl bis(chloroformate)",,106-75-2,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0072e.html,"JP_CHRIP:
-On the basis of results as ""moderately to severely irritating"" in a test using rabbits (SIAP (2010)) and as ""irritating"" in another test using rabbits (IUCLID (2000)), it was classified in Category 2.
-Besides, it is classified in Xi; R38 in EU classification.",,JP_CHRIP,1,ClC(=O)OCCOCCOC(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J27.058J,J-GLOBAL,O=C(Cl)OCCOCCOC(=O)Cl,Train,1,2702,training
-"EU_REACH:
-ethenyl-tris(2-methoxyethoxy)silane",,1067-53-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14177/7/4/2/?documentUUID=7bb0a8d1-2375-4804-8be9-a466e98ad1af,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COCCO[Si](C=C)(OCCOC)OCCOC,https://pubchem.ncbi.nlm.nih.gov/compound/14025,PubChem,C=C[Si](OCCOC)(OCCOC)OCCOC,Train,1,2702,training
-"NZ_CCID:
-Diethyl methoxycarbonylmethanephosphonate","NZ_CCID:
-methyl diethylphosphonoacetate",1067-74-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C1CEAA26-0BBA-40D5-8200-FE29A1C739F3,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCOP(=O)(CC(=O)OC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/66113,PubChem,CCOP(=O)(CC(=O)OC)OCC,Train,1,2702,training
-"EU_REACH:
-2-{2-[(2-chloroacetyl)oxy]ethoxy}ethyl 2-chloroacetate",,106-78-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26885/7/4/2/?documentUUID=a0b4551c-c1af-4ec9-8fbf-2d07cb9d96a4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(COC(=O)CCl)OCCOC(=O)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/15376062,PubChem,O=C(CCl)OCCOCCOC(=O)CCl,Train,1,2702,training
-"EU_REACH:
-2-hydroxy-4'-hydroxyethoxy-2-methylpropiophenone",,106797-53-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1581/7/4/2/?documentUUID=fa204906-e95f-42bb-9b78-085ea461eb80,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C(=O)C1=CC=C(C=C1)OCCO)O,https://pubchem.ncbi.nlm.nih.gov/compound/86266,PubChem,CC(C)(O)C(=O)c1ccc(OCCO)cc1,Test,1,2702,training
-"NZ_CCID:
-Acetohydrazide","NZ_CCID:
-acetic hydrazide",1068-57-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BCE3236E-93BA-4CD3-B5A4-44DC82D82C04,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(=O)NN,https://pubchem.ncbi.nlm.nih.gov/compound/14039,PubChem,CC(=O)NN,Train,1,2702,training
-"JP_CHRIP:
-7-oxa-3-oxiranylbicyclo[4.1.0]heptane
-
-NZ_CCID:
-Vinyl cyclohexene dioxide","JP_CHRIP:
-1,2-epoxy-4-(oxiran-2-yl)cyclohexane
-1-Epoxyethyl-3,4-epoxycyclohexane
-3-Oxiranyl-7-oxabicyclo4.1.0
-4-oxranyl-1,2-epoxycyclohexane
-4-Vinylcyclohexene diepoxide
-4-Vinylcyclohexene dioxide
-4-Vinylcyclohexenedioxide
-7-Oxabicyclo[4.1.0]heptane, 3-oxiranyl-
-Vinyl cyclohexene diepoxide
-
-NZ_CCID:
-1,2-Epoxy-4-(epoxyethyl)cyclohexane, 1-Epoxyethyl-3,4-epoxycyclohexane, 1-Vinyl-3-cyclohexene dioxide, 3-(1,2-Epoxyethyl)-7-oxabicyclo(4.1.0)heptane, 3-(Epoxyethyl)-7-oxabicyclo(4.1.0)heptane, 4-(Epoxyethyl)-7-oxabicyclo(4.1.0)heptane, 4-Vinyl-1,2-cyclohexene diepoxide, 4-Vinyl-1-cyclohexene diepoxide, 4-Vinyl-1-cyclohexene dioxide, 4-Vinylcyclohexene diepoxide, 4-Vinylcyclohexene dioxide, 7-Oxabicyclo(4.1.0)heptane, 3-(epoxyethyl)-, 7-Oxabicyclo(4.1.0)heptane, 3-oxiranyl-, Vinyl cyclohexene diepoxide, Vinylcyclohexene dioxide",106-87-6,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0221e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B27F6DDC-3E6A-4525-ABB0-A7C8401554B9","JP_CHRIP:
-Based on the descriptions that edema and erythema were observed in the rabbit skin application test (ACGIH (7th, 2001) and NTP TR 362 (1989)) and that severe irritation was observed in Draize test on rabbits (PATTY (4th, 1994)), it was classified as Category 2 .
-
-NZ_CCID:
-Skin Irritation
-SPECIES:Rabbit
-RESULT:Severe to extreme irritation
-REFERENCE SOURCE; Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963. 1652 [HSDB]
-
-Eye Irritation
-SPECIES:Rabbit
-RESULT:Severe irritation
-REFERENCE SOURCE: http://www.osha.gov/SLTC/healthguidelines/vinylcyclohexenedioxide/recognition.html)
-[OSHA]",,"JP_CHRIP, NZ_CCID",2,C1OC1C1CCC2OC2C1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J65.676C,J-GLOBAL,C1CC2OC2CC1C1CO1,Train,1,2702,training
-"EU_CLP:
-1,2-epoxybutane",,106-88-7,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCC1CO1,https://pubchem.ncbi.nlm.nih.gov/compound/7834,PubChem,CCC1CO1,Test,1,2702,training
-"AU_HCIS:
-Oxirane, (chloromethyl)-
-
-JP_CHRIP:
-Epichlorohydrin
-
-KR_NCIS:
-Epichlorohydrin
-
-NZ_CCID:
-Oxirane, (chloromethyl)-","AU_HCIS:
-1-chloro-2,3-epoxypropane
-epichlorhydrin
-
-JP_CHRIP:
-1-Chloro-2,3-epoxypropane
-.alpha.-Epichlorohydrin
-1,2-Epoxy-3-chloropropane
-1-chloro-2,3-epoxypropane
-2-Chloropropylene oxide
-Epichlorohydrin
-gamma-Chloropropylene oxide
-
-KR_NCIS:
-1-Chloro-2,3-epoxypropane
-
-NZ_CCID:
-(Chloromethyl) ethylene oxide, 1,2-Epoxy-3-chloropropane, 1-Chloro-2,3-epoxypropane, 2,3-Epoxypropyl chloride, 2-(Chloromethyl) oxirane, 3-Chloro-1,2-epoxypropane, 3-Chloro-1,2-propylene oxide, 3-Chloropropene-1,2-oxide, 3-Chloropropylene oxide, Chloromethyloxirane, Chloropropylene oxide, Epichlorhydrin, Epichlorohydrin, Glycerol epichlorhydrin, Glycerol epichlorohydrin, Glycidyl chloride, Propane, 1-chloro-2,3-epoxy-",106-89-8,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3325
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2073e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E4B8D5F2-D32E-4D09-92E3-873F726B1F4B","JP_CHRIP:
-In a rabbit skin irritation test, in which a stock solution of the substance was applied for 2 - 24-hour, severe irritation and necrosis were observed (Hazard Assessment Report (CERI, NITE) No. 74 (2004)). In accidental cases of occupational exposure, effects such as skin ulcer, erosion and burns are reported (Hazard Assessment Report (CERI, NITE) No. 74 (2004), ACGIH (7th, 2001)). The substance is classified into C; R34 in EU classification. Based on these information, the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Highly irritating
-REFERENCE SOURCE: Shell Nederland Chemie B.V. Hoogvliet-Rotterdam (74)(74) Pallade S., Dorobantu M., Gabrielescu E. (1967), ""Etude experimentale de lintoxication par lepichlorhydrine"", Arch. Mal. Prof. Med. Trav., 28, 505-16. [IUCLID 2000]
-REMARK: EC Classification = Corrosive (causes burns).
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Corrosive
-REFERENCE SOURCE: Shell Nederland Chemie B.V. Hoogvliet-Rotterdam (76)(76) Weil C.S., Condra N., Haun C., Striegel J.A. (1963), ""Experimental carcinogenicity and acute toxicity of representative epoxides"", Am. Ind. Hyg. Ass. J., 24, 305-25. [IUCLID 2000]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID",4,ClCC1CO1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.037A,J-GLOBAL,ClCC1CO1,Train,1,2702,training
-"KR_NCIS:
-Glycidyl acrylate","KR_NCIS:
-2,3-Epoxypropyl acrylate; 2-Propenoic acid, 2-oxiranylmethyl ester; Acrylic acid, 2,3-epoxypropyl ester; Acrylic acid, glycidyl ester; Epoxypropyl acrylate; Glycidyl acrylate; Glycidyl propenate; Oxiran-2-ylmethyl prop-2-enoate",106-90-1,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C=CC(=O)OCC1CO1,https://pubchem.ncbi.nlm.nih.gov/compound/7836,PubChem,C=CC(=O)OCC1CO1,Train,1,2702,training
-"EU_CLP:
-2,3-epoxypropyl methacrylate; glycidyl methacrylate",,106-91-2,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(=C)C(=O)OCC1CO1,https://pubchem.ncbi.nlm.nih.gov/compound/7837,PubChem,C=C(C)C(=O)OCC1CO1,Test,1,2702,training
-"AU_HCIS:
-allyl glycidyl ether
-
-JP_CHRIP:
-1-Allyloxy-2,3-epoxypropane (synonym: Allyl glycidyl ether)
-
-NZ_CCID:
-Allyl 2,3-epoxypropyl ether","AU_HCIS:
-allyl 2,3-epoxypropyl ether
-prop-2-en-1-yl 2,3-epoxypropyl ether
-Oxirane, [(2-propenyloxy)methyl]-
-
-JP_CHRIP:
-Allyl glycidyl ether
-((2-Propenyloxy)methyl)oxirane
-1-(Allyloxy)-2,3-epoxypropane
-1-Allyloxy-2,3-epoxypropane
-Allyl 2,3-epoxypropyl ether
-
-NZ_CCID:
-1,2-Epoxy-3-allyloxypropane, 1-(Allyloxy)-2,3-epoxypropane, AGE, Allyl glycidyl ether, Glycidyl allyl ether, Oxirane, ((2-propenyloxy)methyl)-, Oxirane, [(2-propenyloxy)methyl]-, Propane, 1-(allyloxy)-2,3-epoxy-",106-92-3,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=129
-JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2003.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BC5C815D-35D3-406C-88CC-ABE0952F9BCF","JP_CHRIP:
-【分類根拠】
-（１）～（３）より、区分2とした。なお、（４）の知見から皮膚腐食性が示唆されるが、原典を参照し、皮膚刺激性を支持する知見と判断した。
-
-【根拠データ】
-（１）本物質の蒸気又は液体にばく露された作業者について掻痒感、腫脹及び水疱形成を含む皮膚炎の症例報告がある（ACGIH (7th, 2001)、NITE 初期リスク評価書 (2005)）。
-（２）ウサギ（n=3）を用いた皮膚刺激性試験（閉塞、24時間適用、72時間観察）において、24時間と72時間の紅斑・痂皮の平均スコアは1.33、浮腫の平均スコアは1.83であり、中等度の刺激性を示したとの報告がある（AICIS IMAP (2015)、NITE 初期リスク評価書 (2005)、ACGIH (7th, 2001)、REACH登録情報 (Accessed July 2021)）。
-（３）ウサギを用いた皮膚刺激性試験において、ウサギを用いた試験に基づくと、本物質は皮膚刺激物であるとの報告がある（SIAP (2007)）。
-
-【参考データ等】
-（４）本物質は眼、皮膚、気道に対して腐食性を示し、皮膚に付くと皮膚の乾燥、発赤、痛み、水疱を生じる（MOE 初期評価 (2020)）。
-（５）（４）の原典であるICSC (2018)では、本物質を皮膚刺激性物質としている（ICSC 2018)）。
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 41 [Company Data]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,C=CCOCC1CO1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.520B,J-GLOBAL,C=CCOCC1CO1,Train,1,2702,training
-"NZ_CCID:
-1,5-Hexadiene-3,4-diol",,1069-23-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C0AA5BE4-AB09-4DEF-93A7-32C86FB023D2,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 36 [Company Data]
-Eye Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C=CC(C(C=C)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/14042,PubChem,C=CC(O)C(O)C=C,Train,1,2702,training
-"AU_HCIS:
-Ethane, 1,2-dibromo-
-
-JP_CHRIP:
-Ethane, 1,2-dibromo-
-
-KR_NCIS:
-1,2-Dibromoethane
-
-NZ_CCID:
-1,2-Dibromoethane
-
-US_HSDB:
-Ethylene dibromide","AU_HCIS:
-1,2-dibromoethane
-
-JP_CHRIP:
-1,2-Dibromoethane
-EDB
-Ethane, 1,2-dibromo-
-Ethylene dibromide
-
-NZ_CCID:
-Bromofume, EDB, Ethane, 1,2-dibromo-, Ethylene dibromide, Glycol dibromide, Soilbrom",106-93-4,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1871
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0579e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AEE8D695-C63A-4226-962F-F2521510F191
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/536","JP_CHRIP:
-Although significant irritation accompanied by erythema and edema which progress to necrosis and eschar was observed with repetitive application on shaved rabbit abdominal, it is described that it recovered completely within seven days after the end of exposure (EHC 177 (1996)). On humans, from the results of single exposure test on skin, it is judged to have serious stimulativeness (IUCLID (2000)), and other reports indicate severe irritation (EHC 177 (1996), PATTY (5th, 2001), ATSDR (1992)). From these information, this product may result in corrosion. So it was judged to have severe irritation, it was classified as Category 2.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,BrCCBr,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.038J,J-GLOBAL,BrCCBr,Train,1,2702,training
-"EU_CLP:
-1-bromopropane; n-propyl bromide",,106-94-5,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCCBr,https://pubchem.ncbi.nlm.nih.gov/compound/7840,PubChem,CCCBr,Test,1,2702,training
-"JP_CHRIP:
-3-Bromo-1-propene
-
-KR_NCIS:
-3-Bromo-1-propene
-
-NZ_CCID:
-3-Bromo-1-propene","JP_CHRIP:
-Allyl bromide
-Allyl bromide
-3-Bromo-1-propene
-3-bromoprop-1-ene (synonym:3-bromo-1-propene or allyl bromide)
-
-NZ_CCID:
-allyl bromide",106-95-6,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0023e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/08B655B6-01A6-4606-BCD8-39F3698BA99C","JP_CHRIP:
-In a skin irritation test using mice, after application of 0.5 mL of this substance (99%) for 3 minutes or 4 hours, erythema and edema were observed after 3-minute application, and erythema did not resolve during an observation period (7 days). A 4-hour application group showed erythema and edema which did not resolve during an observation period, and one animal showed tissue destruction and was killed (ECETOC TR66 (1995)). Besides, it is written that this substance is severely irritating to skin (HSDB (Access on June 2015)). From the above results, it was judged to be classified in Category 1.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,BrCC=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.040A,J-GLOBAL,C=CCBr,Train,1,2702,training
-"JP_CHRIP:
-3-Bromo-1-propyne",,106-96-7,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/07-mhlw-0035e.html,"JP_CHRIP:
-Based on the reports that the substance is irritating to the eyes and skin (HSDB (2006)) and that coming into contact with it can irritate and burn the eyes and skin (HSFS (2000)), the substance was classified into Category 2.",,JP_CHRIP,1,BrCC#C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.054G,J-GLOBAL,C#CCBr,Train,1,2702,training
-"AU_HCIS:
-1-Decanamine, N,N-didecyl-",,1070-01-5,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5200,,,AU_HCIS,1,CCCCCCCCCCN(CCCCCCCCCC)CCCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/14049,PubChem,CCCCCCCCCCN(CCCCCCCCCC)CCCCCCCCCC,Train,1,2702,training
-"NZ_CCID:
-2-Ethylhexyl dihydrogen phosphate","NZ_CCID:
-Phosphoric acid, mono(2-ethylhexyl)ester",1070-03-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A3281E22-D4D1-4A1F-96F3-9985FD308231,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCCCC(CC)COP(=O)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/14050,PubChem,CCCCC(CC)COP(=O)(O)O,Train,1,2702,training
-"JP_CHRIP:
-Acrylaldehyde
-
-KR_NCIS:
-Acrolein
-
-NZ_CCID:
-Acrolein
-
-US_HSDB:
-ACROLEIN","JP_CHRIP:
-2-Propen-1-al
-2-Propenal
-Acrolein
-acrolein (synonym:acrylaldehyde)
-acrylaldehyde (synonym:acrolein)
-Acrylic aldehyde
-Prop-2-enal
-
-KR_NCIS:
-2-Propenal
-
-NZ_CCID:
-2-Propenal, Acraldehyde, Acrylaldehyde, Acrylic aldehyde, Allyl aldehyde, Aqualin, Ethylene aldehyde, Prop-2-en-1-al",107-02-8,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2004.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/891B07E1-8729-43BF-B83A-41008FE6788B
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/177","JP_CHRIP:
-【分類根拠】
-（１）、（２）より、区分1とした。
-
-【根拠データ】
-（１）本物質0.01～10％溶液をボランティアの皮膚に適用したパッチテストにおいて、0.01％溶液を適用した8名及び0.1％溶液を適用した10名では陽性反応はみられなかった。1％溶液を適用した48名では12.5％（6/48名）が陽性反応を示し、うち4名で水疱形成を伴う重度の浮腫、2名で紅斑と重度浮腫がみられた。10％溶液では全例（20/20名）の皮膚に水疱、壊死、炎症細胞の浸潤、乳頭状の水腫がみられたとの報告がある（NITE 初期 リスク評価書 (2007)、ECHA RAC Opinion (2012)、CLH Report (2011)、EU RAR (2001)、ATSDR (2007)、AICIS IMAP (2017)、CICAD (2002)、CEPA PSAR (2000)、REACH登録情報（Accessed Juｌｙ 2021)）。
-（２）ウサギ（n=6）を用いた皮膚刺激性試験（14日観察）において、試験期間中に死亡（原因不明）した2例を除いた4例の24/72h後の紅斑スコアの平均は1、浮腫スコアの平均は3であり、3例でみられた影響は14日以内に回復しなかったとの報告がある（ECHA RAC Opinion (2012)、CLH Reoort (2011)、AICIS IMAP (2017)）。
-
-【参考データ等】
-（３）本物質は、平成8年労働省告示第33号（平成25年厚生労働省告示第316号により改正）において、労働基準法施行規則別表第一の二第四号1の厚生労働大臣が指定する単体たる化学物質及び化合物（合金を含む。）に「アクロレイン」として指定されており、本物質にさらされる業務による、特定の症状又は障害を主たる症状又は障害とする疾病（皮膚障害、前眼部障害又は気道・肺障害）が、業務上の疾病として定められている。
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [ECB]
-Eye Irritation
-R PHRASE: R 34 [ECB]",,"JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",4,C=CC=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.045B,J-GLOBAL,C=CC=O,Train,1,2702,training
-"AU_HCIS:
-1-Propene, 3-chloro-
-
-JP_CHRIP:
-Allyl chloride
-
-KR_NCIS:
-3-Chloro-1-propene; Allyl chloride, Chlorallylene","AU_HCIS:
-3-chloropropene
-allyl chloride
-
-JP_CHRIP:
-Allyl chloride
-3-Chloro-1-propene
-3-chloropropene
-3-Chloropropylene
-Allyl chloride",107-05-1,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3679
-JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-mhlw-2015.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP:
-【分類根拠】
-（１）、（２）より、区分2とした。
-
-【根拠データ】
-（１）本物質液体の皮膚への接触で、皮膚に発赤がみられ、灼熱感、痛みを生じ、接触数時間後に強い骨痛を惹き起こす（厚労省 リスク評価書 (2015)、NITE 初期リスク評価 (2008)）。
-（２）皮膚接触が長引くと紅斑と浮腫を生じるおそれがある。極めて少量の本物質液体にばく露を受けた後にも皮膚接触部位付近に深い疼痛（骨痛型）を生じる可能性がある（SIAR (1996)、ACGIH (2011)）。
-
-【参考データ等】
-（３）マウスの尾に本物質原液を3～5時間浸漬した結果、限局性の皮膚の損傷 (発赤、腫脹、一部の例に皮膚の壊死) がみられた（厚労省 リスク評価書 (2015)、NITE 初期リス���評価書 (2008)）。
-（４）ウサギを用いた皮膚刺激性試験（原液、0.1 mL）では、軽微な刺激性がみられたとの報告がある（SIAR (1996)、AICIS IMAP (2013)）。
-（５）EUではSkin Irrit. 2に分類されている（CLP分類結果 (Accessed Jan. 2022)）。",,"AU_HCIS, JP_CHRIP, KR_NCIS",3,ClCC=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.048G,J-GLOBAL,C=CCCl,Train,1,2702,training
-"EU_CLP:
-1,2-dichloroethane; ethylene dichloride",,107-06-2,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C(CCl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11,PubChem,ClCCCl,Test,1,2702,training
-"EU_REACH:
-ethyl 6,8-dichlorooctanoate",,1070-64-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31429/7/4/2/?documentUUID=f951c697-40c9-420a-abc9-853d27afa43c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CCCCC(CCCl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/14053,PubChem,CCOC(=O)CCCCC(Cl)CCCl,Train,1,2702,training
-"NZ_CCID:
-1,4-Butanediol diacrylate",,1070-70-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A1F7A1E7-05D3-4A6B-80EA-FDE3BDD1D11A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C=CC(=O)OCCCCOC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/70613,PubChem,C=CC(=O)OCCCCOC(=O)C=C,Train,1,2702,training
-"NZ_CCID:
-3,3-Dimethylbutyric acid",,1070-83-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2844A019-798A-44CB-A2BF-E83D5F4C2D18,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CC(C)(C)CC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/14057,PubChem,CC(C)(C)CC(=O)O,Train,1,2702,training
-"NZ_CCID:
-1-Iodopropane",,107-08-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6B1697FF-C7F1-4353-8E83-E5490C2AC102,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCCI,https://pubchem.ncbi.nlm.nih.gov/compound/33643,PubChem,CCCI,Train,1,2702,training
-"JP_CHRIP:
-Propylamine
-
-NZ_CCID:
-1-Propanamine","JP_CHRIP:
-1-Aminopropane
-n-Propylamine
-Propanamine
-
-NZ_CCID:
-1-Aminopropane, Monopropylamine, Propylamine",107-10-8,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0047e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EA72A93B-D31E-4C3F-B537-DF250ECC1B3A","JP_CHRIP:
-Based on a report of grade 6 (maximum grade 8) in rabbit test (PATTY (5th, 2001)), a report of ""contact can severely irritate and burn the skin"" (HSFS (2001)), and information of pH 12.6 (20 degC, 100 g/L) (GESTIS (access on Aug. 2009)), the substance was classified into Category 1. As relevant information, another report is noted ""irritating to skin, eyes, and respiratory system in human"" (HSDB (2008)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Guinea pig
-RESULT: Severe
-REFERENCE SOURCE: [Peer Reviewed] [Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963. 2053] HSDB.
-UN CLASS: 8 PG II
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Severe. Graded 9 on a scale of 1 to 10.
-REFERENCE SOURCE: Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986. 768]**PEER REVIEWED** [HSDB]
-UN CLASS: 8 PG II",,"JP_CHRIP, NZ_CCID",2,CCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.052E,J-GLOBAL,CCCN,Train,1,2702,training
-"JP_CHRIP:
-3-Amino-1-propene; Allylamine","JP_CHRIP:
-2-Propenylamine
-3-Aminopropene
-monoallylamine",107-11-9,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2018e.html,"JP_CHRIP:
-[Rationale for the Classification]
-Based on (1), it was classified in Category 1. Besides, since new data were obtained, the category was changed.
-
-[Evidence Data]
-(1) In an in vitro skin corrosion test using an artificial skin model (EpiDerm) in accordance with OECD TG 431, after 3 or 60 minutes of exposure, the viability was 12.8% or 8.4%, respectively (REACH registration dossier (Access on July 2019)).
-
-[Reference Data, etc.]
-(2) This substance is a severe eye and skin irritant (PATTY (6th, 2012)).
-(3) This substance is a severe skin and eye irritant in humans (HSDB (Access on June 2019)).",,JP_CHRIP,1,NCC=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.053C,J-GLOBAL,C=CCN,Train,1,2702,training
-"NZ_CCID:
-Phosphorylethanolamine","NZ_CCID:
-2-Aminoethyl dihydrogen phosphate, Colamine phosphate, Ethanol, 2-amino-, phosphate, Ethanolamine O-phosphate, Ethanolamine phosphate, Mono(2-aminoethyl) phosphate, O-Phosphoethanolamine, O-Phosphorylethanolamine, Phosphoethanolamine, Phosphonoethanolamine, Phosphoric acid, 2-aminoethyl phenyl ester, Phosphoryethanolamine, Ethanol, 2-amino-, dihydrogen phosphate (ester)",1071-23-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CA18F847-CF01-40E1-82B5-58941D64F351,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Chemwatch]
-Eye Irritation
-R PHRASE: R 41 [Chemwatch]",,NZ_CCID,1,C(COP(=O)(O)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/1015,PubChem,NCCOP(=O)(O)O,Train,1,2702,training
-"JP_CHRIP:
-Ethylenediamine
-
-KR_NCIS:
-1,2-Ethanediamine; Ethylenediamine
-
-NZ_CCID:
-Ethylenediamine","JP_CHRIP:
-1,2-Diaminoehtane
-1,2-Diaminoethane
-1,2-Ethanediamine
-1,2-Ethylenediamine
-Dimethylenediamine
-Ethane-1,2-diamine
-Ethylene diamine
-
-NZ_CCID:
-1,2-Diaminoethane, 1,2-Ethanediamine, 1,2-Ethylenediamine, Dimethylenediamine, Ethylendiamine",107-15-3,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-2020e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F417F0FB-94DF-4EFF-8B2B-07BA946DB39C","JP_CHRIP:
-It is described that in a test in which undiluted this substance was applied to rabbits for 1 minute, there were severe inflammation and necrosis at the application site, and some animals had scars that reached the muscle (Initial Risk Assessment Report Ver.1.0, 55 (NITE, CERI, NEDO, 2007)), and in a test by 24-hour occlusive application of the undiluted this substance to rats, necrosis that reached the deep skin occurred and was still seen after 14 days (Initial Risk Assessment Report Ver.1.0, 55 (NITE, CERI, NEDO, 2007)). Therefore, it was classified in Category 1. Besides, pH was 11.8 (5 g/L aqueous solution) (SIDS (2001)).
-
-NZ_CCID:
-Skin Irritation
-R-PHRASE: R 34. [N-CLASS]
-UN CLASS 8, PG II.
-Eye Irritation
-SPECIES:
-RESULT: Corrosive
-REFERENCE SOURCE: Union Carbide Benelux Antwerpen (91) [IUCLID]
-REMARK: EC Classification: Risk of serious damage to eyes.
-R-PHRASE: R 34.[N-CLASS]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,NCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.057F,J-GLOBAL,NCCN,Train,1,2702,training
-"JP_CHRIP:
-N-(phosphonomethyl)glycine [glyphosate]","JP_CHRIP:
-Glycine, N-(phosphonomethyl)-
-Glyphosate
-N-(Phosphonomethyl)glycine",1071-83-6,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0095e.html,"JP_CHRIP:
-It is reported that in a test using rabbits (US EPA guidelines or OECD TG 404, GLP), slight irritation was observed and the score is 0.8. It is reported that in 4 other tests using rabbits (US EPA guidelines or OECD TG 404, GLP), no irritation was observed in any of these tests (EHC 159 (1994), JMPR (2004)).
-Therefore, this substance was classified as ""Not classified.""",Provided,JP_CHRIP,1,OC(=O)CNCP(=O)(O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.359F,J-GLOBAL,O=C(O)CNCP(=O)(O)O,Train,1,2702,training
-"AU_HCIS:
-allyl alcohol
-
-JP_CHRIP:
-Allyl alcohol
-
-KR_NCIS:
-2-Propen-1-ol
-
-NZ_CCID:
-Allyl alcohol
-
-US_HSDB:
-Allyl alcohol","AU_HCIS:
-2-Propen-1-ol
-
-JP_CHRIP:
-Allyl alcohol
-2-Propen-1-ol
-3-Hydroxypropene
-Prop-2-en-1-ol
-Propenyl alcohol
-Vinyl carbinol
-
-KR_NCIS:
-2-Propen-1-ol; 2-Propenol; 2-Propenyl alcohol; Propene-1-ol-3; Vinyl carbinol; Orvinylcarbinol; Propenyl alcohol; 3-Hydroxypropene; Propenol; 1-Propene-3-ol
-
-NZ_CCID:
-2-Propen-1-ol, 2-Propenol, 2-Propenyl alcohol, 3-Hydroxypropene, Allylic alcohol, Vinyl carbinol, Vinylcarbinol",107-18-6,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=128
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2072e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C9C39404-1EB8-4849-AD99-D388A7DBF75E
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/192","JP_CHRIP:
-There are reports of mild irritation or no irritation in skin irritation tests with rabbits (SIDS (2016), Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)), however, there is a description that skin contact with this substance resulted in corrosion and pain in the deeper-lying muscles in humans (DFGOT Vol. 15 (2001), PATTY (6th, 2012)). Based on the above, it was classified in Category 2. Besides, this substance was classified as ""Skin Irrit. 2"" in EU CLP classification (ECHA CL Inventory (Access on June 2017)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,OCC=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.059B,J-GLOBAL,C=CCO,Train,1,2702,training
-"JP_CHRIP:
-Hexanedioic acid, 1,6-dihydrazide","JP_CHRIP:
-adipic dihydrazide
-adipohydrazide
-Hexanedioic acid, dihydrazide",1071-93-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0019e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified as ""Not classified"" from (1).
-
-[Evidence Data]
-(1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 72-hour observation), no skin irritation was seen (erythema/eschar score: 0/0/0, edema score: 0/0/0) (REACH registration dossier (Accessed Aug. 2020)).",Provided,JP_CHRIP,1,NNC(=O)CCCCC(=O)NN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J36.606D,J-GLOBAL,NNC(=O)CCCCC(=O)NN,Train,1,2702,training
-"JP_CHRIP:
-2-Propyn-1-ol
-
-KR_NCIS:
-2-Propyn-1-ol
-
-NZ_CCID:
-2-Propyn-1-ol","JP_CHRIP:
-prop-2-yn-1-ol (synonym:2-Propyn-1-ol)
-
-KR_NCIS:
-Propargyl alcohol; 1-propyne-3-ol; Propynyl alcohol; Ethynlcarbinol; 2-propynl alcohol; 2-propynol; 3-propynol
-
-NZ_CCID:
-1-Hydroxy-2-propyne, 1-Propyn-3-ol, 2-Propynyl alcohol, 3-Hydroxy-1-propyne, 3-Propynol, Ethynyl carbinol, Ethynylcarbinol, Propynyl alcohol",107-19-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2005e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4FE7AA73-DB8C-45CA-AEB8-E9BA07C09AFF","JP_CHRIP:
-[Rationale for the Classification]
-Based on (1) and (2), it was classified in Category 1B.
-
-[Evidence Data]
-(1) There are reports that in two skin irritation tests with rabbits, irritation and superficial necrosis after application of this substance itself and mild irritation after application of a 10% solution were observed (PATTY (6th, 2012), ACGIH (7th, 2001)).
-(2) There is a report that in a skin irritation test (test method equivalent to OECD TG404) with rabbits, in the case of 1-minute application, slight necrosis was observed after 8 days and in the case of application for 5 or 15 minutes, severe necrosis was observed after 8 days (BUA 213 (1999), REACH registration dossier (Accessed Jul. 2018)).
-
-[Reference Data, etc.]
-(3) This substance was classified as ""Skin Irrit. 1B"" in EU CLP.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",Provided,"JP_CHRIP, KR_NCIS, NZ_CCID",3,OCC#C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J13B,J-GLOBAL,C#CCO,Train,1,2702,training
-"AU_HCIS:
-chloroacetaldehyde
-
-JP_CHRIP:
-chloroacetaldehyde","AU_HCIS:
-Acetaldehyde, chloro-
-
-JP_CHRIP:
-Chloroacetaldehyde
-2-Chloro-1-ethanal
-2-Chloroacetaldehyde
-Monochloroacetaldehyde",107-20-0,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=910
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-2006e.html","JP_CHRIP:
-In the rabbit test, application of a 55% aqueous solution of the substance to the abdominal skin caused severe corrosion (DFGMAK-Doc.12 (1999)). In another rabbit test, application of a 30% aqueous solution of the substance caused severe damage to skin (ACGIH (2001)). Based on these documents, the substance was classified as Category 1. As relevant information, the substance was classified as ""C; R34"" in the EU classification (EU-Annex I (Access on Jun. 2009)).",,"AU_HCIS, JP_CHRIP",2,ClCC=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.060F,J-GLOBAL,O=CCCl,Train,1,2702,training
-"JP_CHRIP:
-Ethylene glycol","JP_CHRIP:
-1,2-Dihydroxyethane
-1,2-Ethanediol
-ethane-1,2-diol",107-21-1,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2017e.html,"JP_CHRIP:
-Since in a patch test with 103 subjects, irritation was observed by application of 0.2 mL of the undiluted liquid of this substance (SIDS (2009)), it was classified in Category 2. In addition, there are reports that slight skin irritation was observed in skin irritation tests with rabbits and guinea pigs (CICAD 45 (2002), Initial Risk Assessment Report (NITE, CERI, NEDO, 2007), CEPA (2000)). The findings in humans were added and the category was revised.",,JP_CHRIP,1,OCCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.061D,J-GLOBAL,OCCO,Train,1,2702,training
-"AU_HCIS:
-ethandial … %
-
-JP_CHRIP:
-Glyoxal
-
-NZ_CCID:
-Glyoxal","AU_HCIS:
-glyoxal … %
-
-JP_CHRIP:
-Glyoxal
-1,2-Ethanedione
-Biformyl
-Diformyl
-Ethanedial
-Glyoxal",107-22-2,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=2334
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-2024e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2E5982EE-DB56-4A4B-9E07-284B1EC3C0C7","JP_CHRIP:
-As the results of skin irritation tests with rabbits, it is described that severe irritation (SIDS (2003)), slight irritation (SIDS (2003)), or erythema was observed (CICAD 57 (2004)), or there was no irritation (SIDS (2003)). As effects in humans, it is described that it is considered to irritate the eye, skin, and mucous membrane of humans at present (Environmental Risk Assessment for Chemical Substances vol. 3 (Ministry of the Environment, 2004)). Furthermore, this substance is classified in ""Xi; R36/38"" in EU DSD classification and ""Skin Irrit. 2 H315"" in EU CLP classification. Based on the above information, it was thought to cause reversible and severe irritation, and it was classified in Category 2.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]
-Eye Irritation
-R PHRASE: R 36 [ECB]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,O=CC=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.155A,J-GLOBAL,O=CC=O,Train,1,2702,training
-"JP_CHRIP:
-2-(1-Aziridinyl)ethanol",,1072-52-2,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0005e.html,"JP_CHRIP:
-This substance was classified in Category 2 because it is described that it was an irritant to the skin in humans (HSDB (2006)), and it is reported that there was severe irritation in a standard Draize test in which 500 microL was applied to the rabbit skin for 24 hours (RTECS (1998)).",,JP_CHRIP,1,OCCN1CC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J25.965I,J-GLOBAL,OCCN1CC1,Train,1,2702,training
-"NZ_CCID:
-1-Bromo-2-fluorobenzene",,1072-85-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9E7AF873-6295-46DD-9764-E9E81B18E9FB,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)F)Br,https://pubchem.ncbi.nlm.nih.gov/compound/61259,PubChem,Fc1ccccc1Br,Train,1,2702,training
-"JP_CHRIP:
-Chloromethyl methyl ether","JP_CHRIP:
-Bis(chloromethyl)ether; chloromethyl methyl ether (technical-grade)
-Chloromethoxymethane
-Chloromethyl methyl ether (technical-grade)
-CMME
-Dimethylchloroether",107-30-2,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2023e.html,"JP_CHRIP:
-Based on reports that application to the skin of animals resulted in erythema and necrosis (EHC 201 (1998)) and that contact with the substance can induce a risk of chemical injury or necrosis in humans (ACGIH (2001)), the substance was classified into Category 1.",,JP_CHRIP,1,COCCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.063K,J-GLOBAL,COCCl,Train,1,2702,training
-"NZ_CCID:
-1-Bromo-3-fluorobenzene",,1073-06-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/56A843CA-BAE3-4C1A-B90C-7C92DC489F2C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)Br)F,https://pubchem.ncbi.nlm.nih.gov/compound/14082,PubChem,Fc1cccc(Br)c1,Train,1,2702,training
-"JP_CHRIP:
-Methyl formate","JP_CHRIP:
-Formic acid methyl ester
-Methyl methanoate",107-31-3,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2031e.html,"JP_CHRIP:
-There is a description that the vapour of this substance was strongly irritating to humans (PATTY (6th, 2012)). In reports on animals, there are reports that in a test in which the undiluted liquid of this substance was applied occlusively to rabbits, the primary irritation score was 0.67 (SIDS (2008)), and that it was slightly irritating (SIDS (2008)). From the above, although it was equivalent to ""Not classified"" in reports on animals, there is a description that the vapour was strongly irritating to humans, therefore, it was changed to Category 2.",,JP_CHRIP,1,COC=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.064I,J-GLOBAL,COC=O,Train,1,2702,training
-"KR_NCIS:
-Performic acid",,107-32-4,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C(=O)OO,https://pubchem.ncbi.nlm.nih.gov/compound/66051,PubChem,O=COO,Train,1,2702,training
-"EU_CLP:
-2-methylpentane-2,4-diol",,107-41-5,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(CC(C)(C)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7870,PubChem,CC(O)CC(C)(C)O,Test,1,2702,training
-"JP_CHRIP:
-Hexamethyldisiloxane",,107-46-0,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-meti-2010e.html,"JP_CHRIP:
-[Rationale for the Classification]
-No irritation was observed in (4) in the reliable animal data, but irritation was observed in (1)-(3) of repeated dose studies in humans and animals, and based on the weight of evidence, it was classified in Category 2. Besides, the category was changed by using new information sources.
-
-[Evidence Data]
-(1) There is a report that when the undiluted liquid of this substance was applied occlusively to the skin of 100 subjects (finally 100 subjects out of 11 men and 97 women between 18 to 78 years of age) for 24 hours 9 times at 48 hour intervals (from the third application, semi-occlusive application), superficial skin erosion was observed in a considerable number of subjects after the second application, and no irritation was observed after semi-occlusive application (SIAR (2011), Patty (6th, 2012), NICNAS IMAP (Accessed Dec. 2018), REACH registration dossier (Accessed Dec. 2018)).
-(2) There is a report that when an undiluted solution of this substance was applied to the skin of 64 humans under a non-occlusive dressing for 48 hours, followed by removal of the patch, and then was applied to the same site in the same manner a total of 10 times, skin irritation (redness and swelling) was seen in 10/64 subjects in the first week (SIDS Dossier (2011)).
-(3) There is a report that in a 24-hour repeated application test with rabbits (CTFA guideline, GLP-compliant), this substance was applied 10 times during 14 days under 3 conditions of occluded, semi-occluded or non-occluded, skin irritation was not observed in either semi-occlusive or non-occlusive applications, but skin irritation was observed on Day 4 in occlusive applications (SIAR (2011), NICNAS IMAP (Accessed Dec. 2018), REACH registration dossier (Accessed Dec. 2018)).
-
-[Reference Data, etc.]
-(4) There is a report that in a skin irritation test (equivalent to OECD TG 404, GLP-compliant, n=12 (4 animals/2 periods)) with rabbits, after semi-occlusive application of this substance for 1, 2, 4, 8, 16 and 24 hours, no irritation was observed (SIAR (2011), NICNAS IMAP (Accessed Dec. 2018)).
-(5) There is a report that in a skin irritation test (equivalent to OECD TG 404, n=3/male and female) with rabbits, after 4-hour occlusive application of this substance, no irritation was observed (SIAR (2011), NICNAS IMAP (Accessed Dec. 2018)).",Provided,JP_CHRIP,1,C[Si](C)(C)O[Si](C)(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.247F,J-GLOBAL,C[Si](C)(C)O[Si](C)(C)C,Train,1,2702,training
-"JP_CHRIP:
-Tetraethyl pyrophosphate (TEPP)","JP_CHRIP:
-Tetraethyl pyrophosphate
-TEPP",107-49-3,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2063e.html,"JP_CHRIP:
-There is a description that irritation was caused by contact with skins (HSDB (Access on July 2014)). Therefore, it was classified in Category 2.",,JP_CHRIP,1,CCOP(=O)(OCC)OP(=O)(OCC)OCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J9.263K,J-GLOBAL,CCOP(=O)(OCC)OP(=O)(OCC)OCC,Train,1,2702,training
-"EU_REACH:
-2,2,4,4,6,6-hexamethyl-3,5-dioxa-2,4,6-trisilaheptane",,107-51-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16055/7/4/2/?documentUUID=d6ba6aac-bc83-4063-96af-881fe340ad45,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/24705,PubChem,C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C,Train,1,2702,training
-"EU_REACH:
-2,2,4,4,6,6,8,8,10,10,12,12-dodecamethyl-3,5,7,9,11-pentaoxa-2,4,6,8,10,12-hexasilatridecane",,107-52-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20234/7/4/2/?documentUUID=55ac556e-5b08-4c40-90a7-603a32452e5b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/7875,PubChem,C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C,Train,1,2702,training
-"AU_HCIS:
-Phosphoric acid, dibutyl ester
-
-JP_CHRIP:
-Di-n-butyl phosphate","JP_CHRIP:
-Di-n-butyl phosphate
-Dibutyl acid o-phosphate
-dibutyl phosphate
-Phosphoric acid dibutyl ester
-Phosphoric acid, dibutyl ester",107-66-4,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6822
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2019e.html","JP_CHRIP:
-[Rationale for the Classification]
-Based on (1), it was classified in Category 1. Besides, the category was changed due to the new data obtained.
-
-[Evidence Data]
-(1) In an in vitro skin corrosion test using an artificial human epidermis model (EST-1000) in compliance with OECD TG 431, following 3 minutes and 60 minutes of exposure, cell viabilities were 64% and 2%, respectively (REACH registration dossier (Access on July 2019)).
-
-[Reference Data, etc.]
-(2) It was highly irritating in a skin irritation test in which 0.5 mL was administered semi-occlusively to the ears of rabbits for 8 hours (ACGIH (7th, 2009), SIDS (2004)).
-(3) This substance may cause irritation of the skin in humans (HSDB (Access on June 2019)).",,"AU_HCIS, JP_CHRIP",2,CCCCOP(=O)(O)OCCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J150.769I,J-GLOBAL,CCCCOP(=O)(O)OCCCC,Train,1,2702,training
-"KR_NCIS:
-Bis(2,4,4-trimethylpentyl)phosphinodithioic acid",,107667-02-7,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CC(CC(C)(C)C)CP(=S)(CC(C)CC(C)(C)C)S,https://pubchem.ncbi.nlm.nih.gov/compound/163778,PubChem,CC(CC(C)(C)C)CP(=S)(S)CC(C)CC(C)(C)C,Train,1,2702,training
-"ChemSkin:
-Hydroxycitronellal",,107-75-5,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,CC(CCCC(C)(C)O)CC=O,https://pubchem.ncbi.nlm.nih.gov/compound/7888,PubChem,CC(CC=O)CCCC(C)(C)O,Test,1,2702,training
-"JP_CHRIP:
-2-Methylpentane","JP_CHRIP:
-2-methylpentane
-Dimethylpropylmethane
-Isohexane",107-83-5,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0055e.html,"JP_CHRIP:
-It is described that it was expected to be a skin irritant (PATTY (6th, 2012)), and that this substance may cause defatting, drying and irritation (DFGOT vol.4 (1990)). Also, this substance was classified as ""Skin. Irrit. 2 H315"" in the EU CLP classification (ECHA C&L Inventory (Access on September 2016)). Therefore, the substance was classified in Category 2.",,JP_CHRIP,1,CCCC(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J43.511B,J-GLOBAL,CCCC(C)C,Train,1,2702,training
-"NZ_CCID:
-Isopentylamine",,107-85-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E42E4204-12D3-4C54-9191-3FC8D54CE4E2,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)CCN,https://pubchem.ncbi.nlm.nih.gov/compound/7894,PubChem,CC(C)CCN,Train,1,2702,training
-"JP_CHRIP:
-3-Methyl-2-butenal","JP_CHRIP:
-3,3-Dimethylacrolein
-3-Methylcrotonaldehyde",107-86-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0036e.html,"JP_CHRIP:
-In a test by an occlusive application of undiluted this substance to the rabbit skin for 3 minutes, 1 hour, or 4 hours, edema, erythema, and necrosis were observed from 1 hour after the application, necrosis that occurred hardened with time and became leather-like, and this persisted until day 8, the end of the observation period. As a result, it was judged as corrosive (SIDS (2003)), therefore it was classified in Category 1C. Besides, it is reported that necrosis in addition to erythema and edema were also found in another test by a 20-hour occlusive application of undiluted this substance to the rabbit skin, and it was assessed to be corrosive (SIDS (2003)).",,JP_CHRIP,1,CC(=CC=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J9.338F,J-GLOBAL,CC(C)=CC=O,Train,1,2702,training
-"EU_REACH:
-butyric acid
-
-JP_CHRIP:
-butyric acid
-
-NZ_CCID:
-Butyric acid","JP_CHRIP:
-1-Propanecarboxylic acid
-Butanic acid
-Ethylacetic acid
-n-Butanoic acid",107-92-6,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13507/7/4/2/?documentUUID=93aea964-09a1-4fae-ad50-7b7cbac551aa
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0159e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B2AFBB3F-959A-4F22-A238-D2B061D4F1F1","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-In List 1 data (PATTY (5th, 2001)), the substance is documented to be a severe irritant in rabbit tests, and in List 2 data (IUCLID (2000)), it is reported to be corrosive in rabbit tests (OECD Guidelines 404). In addition, it is rated as R34 in the EU classification.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,CCCC(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.068A,J-GLOBAL,CCCC(=O)O,Train,1,2702,training
-"JP_CHRIP:
-3-Chloropropionic acid
-
-NZ_CCID:
-3-Chloropropionic acid","JP_CHRIP:
-3-Chloropropionic acid
-Propanoic acid, 3-chloro-",107-94-8,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2037e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B7EDFCF0-F122-4BE5-BAA3-19B92CC7E6C6","JP_CHRIP:
-[Rationale for the Classification]
-It was classified in Category 1 from (1), (2).
-
-[Evidence Data]
-(1) The pH of this substance (200 g/L) was 0.9 (GESTIS (Access on May 2020)).
-(2) This substance and its aqueous solutions were strong irritative/corrosive to the eye and skin (GESTIS (Access on May 2020)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,OC(=O)CCCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.069J,J-GLOBAL,O=C(O)CCCl,Train,1,2702,training
-"EU_REACH:
-β-alanine",,107-95-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2084/7/4/2/?documentUUID=d7e37368-f9ac-430c-90cc-889f6f27ce53,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CN)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/239,PubChem,NCCC(=O)O,Train,1,2702,training
-"JP_CHRIP:
-beta-Mercaptopropionic acid
-
-NZ_CCID:
-3-Mercaptopropionic acid",,107-96-0,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0161e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8C417E85-018E-4EAB-9F06-9D09571A24E0","JP_CHRIP:
-The substance was classified as Category 1 based on the documented case of ""corrosive"" (SIDS (2009)) resulted from the rabbit test in which necrosis and burns accompanied by erythema and edema were observed within 15 minutes of occlusive application of the test substance.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,OC(=O)CCS,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J38.166G,J-GLOBAL,O=C(O)CCS,Train,1,2702,training
-"NZ_CCID:
-Chlorodiphenylphosphine",,1079-66-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7C22DC71-BBFE-4D3A-B969-4C56939405CC,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)P(C2=CC=CC=C2)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/66180,PubChem,ClP(c1ccccc1)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-1,2-Ethanediamine, N,N-dimethyl-","NZ_CCID:
-N,N-dimethylethylenediamine",108-00-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/39607F72-2040-486E-B82E-2BCA0E277514,"NZ_CCID:
-Skin Irritation
-UN CLASS: PG II",,NZ_CCID,1,CN(C)CCN,https://pubchem.ncbi.nlm.nih.gov/compound/66053,PubChem,CN(C)CCN,Train,1,2702,training
-"AU_HCIS:
-Ethanol, 2-(dimethylamino)-
-
-JP_CHRIP:
-2-dimethylaminoethanol; N,N-dimethylethanolamine
-
-NZ_CCID:
-Dimethylaminoethanol
-
-US_HSDB:
-2-DIMETHYLAMINOETHANOL","AU_HCIS:
-2-dimethylaminoethanol
-N,N-dimethylethanolamine
-
-JP_CHRIP:
-2-dimethylaminoethanol
-Dimethylethanolamine
-N,N-Dimethyl-2-hydroxyethylamine
-N,N-dimethylethanolamine
-
-NZ_CCID:
-(2-Hydroxyethyl)dimethylamine, 2-(Dimethylamino) ethanol, 2-(Dimethylamino)-1-ethanol, 2-(Dimethylamino)ethanol, 2-(N,N-Dimethylamino)ethanol, 2-Dimethylaminoethanol, Bimanol, Deanol, Dimethyl(2-hydroxyethyl)amine, Dimethyl(hydroxyethyl)amine, Dimethylethanolamine, Dimethylmonoethanolamine, Ethanol, 2-(dimethylamino)-, N,N-Dimethyl-2-aminoethanol, N,N-Dimethyl-2-hydroxyethylamine, N,N-Dimethyl-N-(2-hydroxyethyl)amine, N,N-Dimethylaminoethanol, N,N-Dimethylethanolamine, N-(2-Hydroxyethyl)dimethylamine, Norcholine, Propamine A, Texacat DME",108-01-0,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1879
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0034e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/11B13060-5626-4367-8D9D-F5F7DAA55F78
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1329","JP_CHRIP:
-Since GLP tests using rabbits concluded that the substance was corrosive (IUCLID, 2000), it was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-R-PHRASE: R 34. [N-CLASS]
-Eye Irritation
-R-PHRASE: R 34. [N-CLASS]",,"AU_HCIS, JP_CHRIP, NZ_CCID, US_HSDB",4,CN(C)CCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.068G,J-GLOBAL,CN(C)CCO,Train,1,2702,training
-"EU_REACH:
-4-methylpentan-2-one
-
-JP_CHRIP:
-Methyl isobutyl ketone","JP_CHRIP:
-4-Methyl-2-pentanone
-4-Methyl-2-pentanone; Methyl isobutyl ketone
-4-methylpentan-2-one
-Hexone
-Isopropylacetone
-methylisobutyl ketone
-methylisobutyl ketone(2-methyl-4-pentanone)
-MIBK",108-10-1,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14866/7/4/2/?documentUUID=61c2bbba-4873-420b-b530-05db459b7160
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0099e.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-There is a report that in a skin irritation test with rabbits, as a result of an occlusive application with this substance for 10 hours, erythema was persistent until after 24 hours (SIDS (2011), EHC117 (1990), NTP TR 538 (2007)). In addition, there is a report that in a skin irritation test with guinea pigs, as a result of an application of this substance (5 or 10 mL), slight irritation was observed (DFGOT Vol. 13 (1999), PATTY (6th, 2012)). From the above, based on reports that recovery property was observed and slight irritation was observed, this substance was classified as ""Not classified"" (Category 3 in UN GHS classification).",Provided,"EU_REACH, JP_CHRIP",2,CC(C)CC(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.861D,J-GLOBAL,CC(=O)CC(C)C,Train,1,2702,training
-"NZ_CCID:
-Isopentanoyl chloride","NZ_CCID:
-isovaleryl chloride",108-12-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/867E4D5E-34C4-417A-A200-391425F8F73A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)CC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/66054,PubChem,CC(C)CC(=O)Cl,Train,1,2702,training
-"NZ_CCID:
-1-(Dimethylamino)-2-propanol",,108-16-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/741C2CB9-124E-45D9-BCFF-B9F7FA9CCF1B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(CN(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/37511,PubChem,CC(O)CN(C)C,Train,1,2702,training
-"KR_NCIS:
-Guazatine",,108173-90-6,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C(CCCCN=C(N)N)CCCNCCCCCCCCN=C(N)N,https://pubchem.ncbi.nlm.nih.gov/compound/3526,PubChem,NC(N)=NCCCCCCCCNCCCCCCCCN=C(N)N,Train,1,2702,training
-"NZ_CCID:
-Imidodicarbonic diamide","NZ_CCID:
-Allophanic acid anhydride, Allophanimide, Allophanimidic acid, Biuret, Carbamylurea, Diurea",108-19-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A3D2097A-4C0D-45C6-B2AC-7A230BDC06CC,,,NZ_CCID,1,C(=O)(N)NC(=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/7913,PubChem,NC(=O)NC(N)=O,Train,1,2702,training
-"EU_REACH:
-isopropenyl acetate",,108-22-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17298/7/4/2/?documentUUID=37ceb158-2d81-44c8-ab37-dc1cdb5a3eb5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)OC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/7916,PubChem,C=C(C)OC(C)=O,Train,1,2702,training
-"JP_CHRIP:
-Isopropyl chloroformate","JP_CHRIP:
-Carbonochloridic acid 1-methylethyl ester
-Chloroformic acid, isopropyl ester
-isopropyl 1-chloromethanoate
-Isopropyl chlorocarbonate
-isopropyl chloroformate
-Isopropyl chloromethanate",108-23-6,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0067e.html,"JP_CHRIP:
-Based on a report that direct dropwise application to the skin causes deep necrosis and eschar formation in a guinea pig test (PATTY (5th, 2001)) and a report of ""irritating and corrosive to the skin"" (HSDB (2003)), the substance was classified into Category 1.",,JP_CHRIP,1,CC(C)OC(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.720E,J-GLOBAL,CC(C)OC(=O)Cl,Train,1,2702,training
-"JP_CHRIP:
-Acetic anhydride
-
-NZ_CCID:
-Acetic anhydride
-
-US_HSDB:
-Acetic anhydride","JP_CHRIP:
-Acetic acid, anhydride
-Acetic oxide
-Acetyl oxide
-Ethanoic anhydride
-
-NZ_CCID:
-Acetanhydride, Acetic acid, anhydride, Acetic oxide, Acetyl acetate, Acetyl anhydride, Acetyl ether, Acetyl oxide, Ethanoic anhydride",108-24-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2021e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/54C46A7E-73BC-4DB8-A03B-0BF27040E37C
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/233","JP_CHRIP:
-[Rationale for the Classification]
-Based on (1)-(4), it was classified in Category 1.
-
-[Evidence Data]
-(1) This substance is a severe irritant to the eyes, mucous membranes and skin, and severe burns and vesiculation of the skin were reported from liquid splashes (ACGIH (7th, 2001)).
-(2) In a skin irritation test with rabbits, under occluded conditions for 24 hours, it caused severe burns and blisters (ACGIH (7th, 2011)).
-(3) This substance is corrosive to the skin, eyes and mucous membranes (SIDS (2002)).
-(4) This substance is severely irritating to the skin and eyes, and direct contact with the liquid may result in burns (OEL Documentations (Japan Society For Occupational Health (JSOH), 1990), HSDB (Access on June 2019)).
-
-[Reference Data, etc.]
-(5) It was reported that it was mildly irritative in a skin irritation test in which 0.5 mL of this substance was applied to rabbits for 24 hours (DFGOT vol.13 (1999), SIDS (2002)).
-(6) It was classified in Skin Irrit. 1B (H314) in the EU CLP Classification (EU CLP classification (Access on July 2019)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,CC(=O)OC(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.417A,J-GLOBAL,CC(=O)OC(C)=O,Train,1,2702,training
-"EU_CLP:
-succinic anhydride",,108-30-5,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1CC(=O)OC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/7922,PubChem,O=C1CCC(=O)O1,Test,1,2702,training
-"EU_REACH:
-1,4,5,8-tetrakis[(4-butylphenyl)amino]-9,10-dihydroanthracene-9,10-dione",,108313-21-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30120/7/4/2/?documentUUID=b23202ed-0739-4568-8f45-7067c52ae660,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC1=CC=C(C=C1)NC2=C3C(=C(C=C2)NC4=CC=C(C=C4)CCCC)C(=O)C5=C(C=CC(=C5C3=O)NC6=CC=C(C=C6)CCCC)NC7=CC=C(C=C7)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/15918419,PubChem,CCCCc1ccc(Nc2ccc(Nc3ccc(CCCC)cc3)c3c2C(=O)c2c(Nc4ccc(CCCC)cc4)ccc(Nc4ccc(CCCC)cc4)c2C3=O)cc1,Test,1,2702,training
-"JP_CHRIP:
-propylene carbonate","JP_CHRIP:
-2-oxo-4-methyl-1,3-dioxolane
-propylene carbonate",108-32-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0160e.html,"JP_CHRIP:
-The classification is based on descriptions that the substance was found to be a slight irritant in rabbit tests (PATTY (5th, 2001)) and it caused no irritation in other rabbit tests (OECD Guidelines 404) (IUCLID (2000)).",Provided,JP_CHRIP,1,CC1COC(=O)O1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.073C,J-GLOBAL,CC1COC(=O)O1,Train,1,2702,training
-"NZ_CCID:
-1,3-Dibromobenzene","NZ_CCID:
-m-dibromobenzene",108-36-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5670FA21-79D0-497C-BE19-8255D9DFE21D,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)Br)Br,https://pubchem.ncbi.nlm.nih.gov/compound/7927,PubChem,Brc1cccc(Br)c1,Train,1,2702,training
-"NZ_CCID:
-1-Bromo-3-chlorobenzene","NZ_CCID:
-3-bromochlorobenzene",108-37-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/619EABE3-AF39-4281-8C38-7DA3F186EB4A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)Br)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7928,PubChem,Clc1cccc(Br)c1,Train,1,2702,training
-"AU_HCIS:
-m-xylene
-
-JP_CHRIP:
-m-Xylene
-
-KR_NCIS:
-m-xylene
-
-NZ_CCID:
-Benzene, 1,3-dimethyl-
-
-US_HSDB:
-3-XYLENE","AU_HCIS:
-Benzene, 1,3-dimethyl-
-
-JP_CHRIP:
-1,3-Dimethylbenzene
-Benzene, 1,3-dimethyl-
-m-Xylene and p-Xylene
-m-Xylol
-meta-Xylene
-Xylene
-Xylenes
-
-KR_NCIS:
-1,3-Dimethylbenzene; 1,3-Xylene; Benzene, 1,3-dimethyl; Benzene, 1,3-dimethyl-; meta-Xylene; m-Xylol; XYLENE, M-
-
-NZ_CCID:
-1,3-Dimethylbenzene, 1,3-Xylene, m-Methyltoluene, m-Xylene",108-38-3,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3098
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2136e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/852DCD51-2229-41B5-BC0F-18D7DDC4B0BB
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/135","JP_CHRIP:
-It is reported that after an application to the skin of rabbits (application time unknown), irritation was observed (Hazard Assessment Report (CERI, NITE, 2008)). It is reported that in a test where this substance was applied to both hands of 13 volunteers in a 20-min immersion, they showed a feeling of burns (burning sensation) after a 10-minute application and they recovered within 10 minutes after the end of the application. It is also reported that erythema was observed at the application spot but this disappeared within a few hours (Hazard Assessment Report (CERI, NITE, 2008)). Based on the above results, this substance was classified in Category 2.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Moderate
-REFERENCE SOURCE: Prehled Prumyslove Toxikologie; Organicke Latky, Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 (-,30,1986). [RTECS]
-R-PHRASE: R 38 Irritating to skin. [IUCLID 2000]
-Eye Irritation
-SPECIES: Human
-RESULT: Moderately irritating
-REFERENCE SOURCE: Enichem S.p.A. Milan (61)(61) Hastings L, Cooper GP et.al. : Human sensory response to selected petroleum hydrocarbons. Adv Mod Environ Toxicol 1984; 6: 225-270. [IUCLID 2000]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,Cc1cccc(C)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.421J,J-GLOBAL,Cc1cccc(C)c1,Train,1,2702,training
-"AU_HCIS:
-m-cresol [1]
-
-JP_CHRIP:
-m-Cresol
-
-KR_NCIS:
-m-Cresol
-
-NZ_CCID:
-3-Cresol
-
-US_HSDB:
-m-CRESOL","AU_HCIS:
-o-cresol  [2]
-p-cresol  [3]
-mix-cresol [4]
-Phenol, 3-methyl-
-m-cresol
-o-cresol
-p-cresol
-
-JP_CHRIP:
-1-Hydroxy-3-methylbenzene
-3-Cresol
-3-Hydroxytoluene
-3-Methylphenol
-cresol
-m-cresol
-m-Cresol; 3-Methylphenol
-Phenol, 3-methyl-
-
-KR_NCIS:
-1-Hydroxy-3-methylbenzene; 1-Hydroxy-3-methylbenzol; 1-Oxy-3-methylbenzol; 3-Cresol; 3-Hydroxytoluene; 3-Hydroxytoluol; 3-Kresol; 3-Methylphenol; m-Cresylic acid; m-Hydroxytoluene; M-Hydroxytoluol; M-Kresol; M-Kresylsaeure; m-Methylphenol; M-Oxytoluol; M-Tolylalkohol; Phenol, 3-Methyl; Phenol, 3-methyl-
-
-NZ_CCID:
-1-Hydroxy-3-methylbenzene, 3-Hydroxytoluene, 3-Methyl phenol, Metacresol, m-Cresol",108-39-4,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1066
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2137e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/64AA8ADA-9DD7-4180-A4DD-37D14CC47600
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1815","JP_CHRIP:
-There is a report that when 0.5 mL of the undiluted liquid of this substance was applied to the skin of rabbits, severe erythema and edema occurred within 24 hours and this did not disappear within 72 hours (SIDS (2005)). In other tests with rabbits, there is a report that irreversible tissue destruction was observed 4 hours after application of this substance (EHC 168 (1995)), and that severe irritation and corrosion were observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)). From the above results, it was classified in Category 1. Besides, this substance was classified in ""C; R34"" in EU DSD classification and in ""Skin Corr. 1B H314"" in EU CLP classification.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Dermal application of cresols (0.5 ml of o-, m- or p-cresol or a technical mixture of all three isomers) for 4 h caused visible and irreversible tissue destruction.
-REFERENCE SOURCE: (Vernot et al., 1977). Cresols (EHC 168, 1995) [INCHEM]
-Eye Irritation
-R-PHRASE: R 34 Causes burns. [N-CLASS]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,Cc1cccc(O)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.186J,J-GLOBAL,Cc1cccc(O)c1,Train,1,2702,training
-"JP_CHRIP:
-m-Toluidine","JP_CHRIP:
-3-Aminophenylmethane
-3-Aminotoluene
-3-Methyl aminobenzene
-Benzenamine, 3-methyl-
-m-Methylaniline",108-44-1,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2041e.html,"JP_CHRIP:
-Based on a report that this substance was moderately or slightly irritating in a skin irritation test with rabbits (SIDS (2003)), it was classified in Category 2.",,JP_CHRIP,1,Cc1cccc(N)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.249B,J-GLOBAL,Cc1cccc(N)c1,Train,1,2702,training
-"EU_CLP:
-resorcinol; 1,3-benzenediol",,108-46-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC(=CC(=C1)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/5054,PubChem,Oc1cccc(O)c1,Test,1,2702,training
-"NZ_CCID:
-Pyridine, 2,6-dimethyl-","NZ_CCID:
-2,6-Lutidine",108-48-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8D22C0E8-B5C8-42DA-A1E7-D10E8BD40117,"NZ_CCID:
-Skin Irritation
-SPECIES: Guinea Pig
-RESULT: Intense irritation.
-REFERENCE SOURCE: [Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963. 2184]**PEER REVIEWED** [HSDB]
-Eye Irritation
-SPECIES: Guinea Pig
-RESULT: Intense irritation.
-REFERENCE SOURCE: [Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963. 2184]**PEER REVIEWED** [HSDB]",,NZ_CCID,1,CC1=NC(=CC=C1)C,https://pubchem.ncbi.nlm.nih.gov/compound/7937,PubChem,Cc1cccc(C)n1,Train,1,2702,training
-"NZ_CCID:
-Glutaric anhydride",,108-55-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AE44F97E-0096-4383-8E3B-1A061BA8A61C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 41 [Company Data]",,NZ_CCID,1,C1CC(=O)OC(=O)C1,https://pubchem.ncbi.nlm.nih.gov/compound/7940,PubChem,O=C1CCCC(=O)O1,Train,1,2702,training
-"JP_CHRIP:
-m-Divinylbenzene","JP_CHRIP:
-divinylbenzene
-m-(or p-)divinylbenzene
-m-Divinylbenzene",108-57-6,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2100e.html,"JP_CHRIP:
-[Rationale for the Classification]
-Based on (1), it was classified in Category 2. Besides, since no data for each isomer were available, this substance was classified in accordance with the data on the isomeric mixture.
-
-[Evidence Data]
-(1) The isomeric mixture of this substance is moderately irritating to the eyes and skin (PATTY (6th, 2012)).
-
-[Reference Data, etc.]
-(2) It was classified as ""Skin Irrit. 2 (H315)"" in the EU-CLP classification (EU CLP classification (Access on November 2019)).",,JP_CHRIP,1,C=Cc1cccc(C=C)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J43.441H,J-GLOBAL,C=Cc1cccc(C=C)c1,Train,1,2702,training
-"JP_CHRIP:
-1,3,5-Trimethylbenzene","JP_CHRIP:
-Benzene, 1,3,5-trimethyl-
-mesitylene",108-67-8,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2006.html,"JP_CHRIP:
-【分類根拠】
-（１）、（２）より、区分2とした。
-
-【根拠データ】
-（１）ウサギ（n=6）を用いた皮膚刺激性試験（OECD TG 404、4時間適用、6日観察）において、1時間後からごく軽度の発赤がみられ、144時間後には中等度から重度になった。1時間後から軽度の浮腫がみられたが、144時間後には消失したとの報告がある（NITE 初期リスク評価書 (2008)）。
-（２）本物質は実験動物で皮膚に対し刺激性を示す（NITE 初期リスク評価書 (2008)）。
-
-【参考データ等】
-（３）ウサギを用いた皮膚刺激性試験（24時間適用）において、中程度の刺激性がみられたとの報告がある（NITE 初期リスク評価書 (2008)）。",Provided,JP_CHRIP,1,Cc1cc(C)cc(C)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.424D,J-GLOBAL,Cc1cc(C)cc(C)c1,Train,1,2702,training
-"JP_CHRIP:
-3,5-xylenol; 3,5-Dimethylphenol
-
-KR_NCIS:
-3,5-Dimethylphenol
-
-NZ_CCID:
-Phenol, 3,5-dimethyl-","JP_CHRIP:
-3,5-Xylenol
-Phenol, 3,5-dimethyl-
-
-KR_NCIS:
-1,3,5-Xylenol; 1-Hydroxy-3,5-dimethylbenzene; 3,5-Xylenol; Phenol, 3,5-dimethyl-; XYLENOL
-
-NZ_CCID:
-3,5-XYLENOL",108-68-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2028e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9D1BCFDA-2209-4D23-A4E5-DA83B7A37971","JP_CHRIP:
-[Rationale for the Classification]
-Based on (1) and (2), it was classified in Category 1.
-
-[Evidence Data]
-(1) Moderate burns to the skin were reported in rabbits after administration to the skin (concentration not specified) (NICNAS IMAP (Access on August 2019)).
-(2) It was classified in ""Skin Corr. 1B (H314)"" in EU-CLP classification (EU CLP classification (Access on May 2019)).
-
-[Reference Data, etc.]
-(3) In a 24-hour occlusive skin irritation study with rabbits (Polyethylene glycol (PEG) 400 was used as vehicle), slight edema was observed in half of the animals at 24 hours after application and disappeared after 72 hours. PII was 0.25 (ACGIH (7th, 2019), (REACH registration dossier (Access on July 2019))).
-
-NZ_CCID:
-Skin Irritation
-SPECIES:
-RESULT: Corrosive
-REFERENCE SOURCE: [NTP]
-Eye Irritation
-SPECIES:
-RESULT: Corrosive
-REFERENCE SOURCE: [NTP]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,Cc1cc(C)cc(O)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.425B,J-GLOBAL,Cc1cc(C)cc(O)c1,Train,1,2702,training
-"NZ_CCID:
-Phloroglucinol",,108-73-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/909AA9DA-DD17-4ED4-A836-58C0540CD89B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=C(C=C(C=C1O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/359,PubChem,Oc1cc(O)cc(O)c1,Train,1,2702,training
-"EU_REACH:
-trichloro-1,3,5-triazine
-
-JP_CHRIP:
-2,4,6-Trichloro-1,3,5-triazine
-
-NZ_CCID:
-Cyanuric chloride","JP_CHRIP:
-2,4,6-Trichloro-1,3,5-triazine
-2,4,6-Trichloro-s-triazine
-2,4,6-trichlorotriazine
-Chlorotriazine
-Cyanuric acid trichloride
-Trichlorocyanidine
-Tricyanogen chloride",108-77-0,Cat 2,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14952/7/4/2/?documentUUID=6fca88de-dae0-47e5-80ef-0c9846e1b282
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2022e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A0EF4151-29A4-4366-B324-0450437AE005","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-[Rationale for the Classification]
-Based on (1)-(3), it was classified in Category 2.
-
-[Evidence Data]
-(1) In a skin irritation test (4-hour semi-occlusive application) with rabbits according to OECD TG 404, the mean scores at 24/48/72 hours were 0.67-1.67, and the mean score exceeded 1.5 in only 1/6 animals (SIDS (2004)).
-(2) No irritation was observed in a skin irritation test (4-hour semi-occlusive application) with rabbits according to OECD TG 404 (SIDS (2004)).
-(3) This substance produced severe skin irritation in rabbits (PATTY (6th, 2012)).
-
-[Reference Data, etc.]
-(4) In a skin irritation test (24-hour semi-occlusive application) with rabbits according to OECD TG 404, irritation was observed (SIDS (2004)).
-(5) In humans, exposure to this substance causes caustic effects to the skin, eyes and respiratory tract (SIDS (2004)).
-(6) It was classified as ""Skin Corr. 1B (H314)"" in the EU-CLP classification (EU CLP classification (Access on July 2019)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,Clc1nc(Cl)nc(Cl)n1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.080F,J-GLOBAL,Clc1nc(Cl)nc(Cl)n1,Train,1,2702,training
-"JP_CHRIP:
-Melamine","JP_CHRIP:
-1,3,5-Triazine-2,4,6-triamine
-2,4,6-Triamino-1,3,5-triazine
-2,4,6-triamino-1,3,5-triazine (melamine)
-Cyanurotriamide",108-78-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-0004e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified as ""Not classified"" from (1) - (3).
-
-[Evidence Data]
-(1) No skin reactions were observed in a skin irritation test with rabbits according to OECD TG 404 (REACH registration dossier (Access on June 2020)).
-(2) In a patch test in humans, no skin irritation or sensitization was found. And dermatitis was reported from the manufacture of melamine-formaldehyde resins or intermediate reaction products of formaldehyde and this substance, but not this substance itself (Environmental Risk Assessment for Chemical Substances vol. 8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)).
-(3) This substance produced little or no irritation or sensitization when its 1% aqueous solution was applied to the guinea pig skin under occlusion. There was a similar result also in rabbits (Patty (6th, 2012), GESTIS (Access on April 2020)).",Provided,JP_CHRIP,1,Nc1nc(N)nc(N)n1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.428G,J-GLOBAL,Nc1nc(N)nc(N)n1,Train,1,2702,training
-"JP_CHRIP:
-2,6-Dimethylheptan-4-ol",,108-82-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0037e.html,"JP_CHRIP:
-The substance was classified as ""Not classified"" based on the rabbit test (OECD TG404) in which erythema and edema were not observed at 24, 48 and 72 hours after patch removal, and the PII was 0 (ECETOC TR66 (1995)).",Provided,JP_CHRIP,1,CC(C)CC(O)CC(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J58.121F,J-GLOBAL,CC(C)CC(O)CC(C)C,Train,1,2702,training
-"JP_CHRIP:
-Diisobutyl ketone","JP_CHRIP:
-2,6-Dimethyl-4-heptanone
-2,6-dimethylheptan-4-one
-Isovalerone",108-83-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0095e.html,"JP_CHRIP:
-As for skin irritation tests (OECD TG404) with rabbits, both results of slight irritation and no irritation are reported as a result of a semi-occlusive application of this substance for 4 hours (SIDS (2004)). In addition, there is a report that in other skin irritation test with rabbits, as a result of a semi-occlusive application of 0.5 mL of this substance for 4 hours, erythema (average score 1.9) and edema (average score 0.4) were observed, but resolved within 14 days after the application (SIDS (2004)). From the above, it was classified as ""Not classified"" (Category 3 in UN GHS classification).",Provided,JP_CHRIP,1,CC(C)CC(=O)CC(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.081D,J-GLOBAL,CC(C)CC(=O)CC(C)C,Train,1,2702,training
-"JP_CHRIP:
-1,3-Dimethylbutyl acetate","JP_CHRIP:
-4-Methyl-2-pentanol, acetate
-Acetic acid, 1,3-dimethylbutyl ester
-Methyl amyl acetate; 4-Methyl-2-amyl acetate; 4-Methyl-2-pentanol, acetate; 2-Pentanol, 4-methyl-, acetate
-Methylisoamyl acetate",108-84-9,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2116e.html,"JP_CHRIP:
-Since there is a description that moderate irritation was observed in a test with rabbits (PATTY (6th, 2012)), it was classified in Category 2.",,JP_CHRIP,1,CC(C)CC(C)OC(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J48.640J,J-GLOBAL,CC(=O)OC(C)CC(C)C,Train,1,2702,training
-"JP_CHRIP:
-Bromobenzene
-
-NZ_CCID:
-Bromobenzene","JP_CHRIP:
-Benzene, bromo-
-Bromobenzene
-Phenyl bromide",108-86-1,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0072e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7EA6E6B5-63E7-4391-A3CE-151EF452E3FD","JP_CHRIP:
-Based on reports of irritating for the skin (PATTY (5th, 2001)) and irritant to skin (HSDB (2003)), and classification as Xi; R38 in EU classification (EU-Annex I (access on Aug. 2009)), the substance was classified into Category 2
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,"JP_CHRIP, NZ_CCID",2,Brc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.867C,J-GLOBAL,Brc1ccccc1,Train,1,2702,training
-"AU_HCIS:
-Toluene
-
-JP_CHRIP:
-Toluene
-
-KR_NCIS:
-Toluene
-
-NZ_CCID:
-Benzene, methyl-
-
-US_HSDB:
-TOLUENE","AU_HCIS:
-Benzene, methyl-
-
-JP_CHRIP:
-Methylbenzene
-Phenylmethane
-Toluol
-
-NZ_CCID:
-Toluol, Methylbenzene, Methylbenzol, Phenylmethane, Methacide, Toluene, Methyl benzene",108-88-3,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4513
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-2003e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/53C72B78-1E2C-4FD2-8398-0BA30C6A80A8
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/131","JP_CHRIP:
-In a test by a 4-hour semi-occlusive application of 0.5 mL of the test substance to seven rabbits (Annex V, method B2), by 72 hours after the application, all the animals showed slight to severe erythema and slight edema, on day 7, well-defined to severe erythema in all the animals and very slight to slight edema in five animals were observed, and it was assessed as moderately irritating (EU-RAR (2003)). Therefore, it was classified in Category 2. Besides, it is reported that it was slightly irritating in another skin irritation test with six rabbits (OECD TG 404), although data details are unknown (EU-RAR (2003)), and it is reported that eschar formation was seen in a test with guinea pigs given a 24-hour occlusive application of 0.5 mL of undiluted this substance, and after five days, a thick layer of scales and slight superficial fissuring of the skin were found (EU-RAR (2003)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Irritating
-REFERENCE SOURCE: Deutsche Shell Chemie GmbH Eschborn Deutsche Shell Chemie Eschborn (120)[IUCLID 2000]
-REMARK: EC Classification: Irritating
-
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Irritating
-REFERENCE SOURCE: Source: Deutsche Shell Chemie GmbH Eschborn Deutsche Shell Chemie Eschborn (123) [IUCLID 2000]
-REMARK: EC Classification: Irritating",Provided,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,Cc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.868A,J-GLOBAL,Cc1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-4-methylpyridine; 4-picoline
-
-NZ_CCID:
-4-Methylpyridine
-
-US_HSDB:
-4-METHYLPYRIDINE","JP_CHRIP:
-4-Picoline
-gamma-picoline
-p-Picoline
-
-NZ_CCID:
-4-picoline",108-89-4,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0161e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D8A74D17-6339-4DAA-B614-4ED04FD57ADA
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/5386","JP_CHRIP:
-In rabbit tests, three types of isomers were found to be moderately to severely irritating, and 4-picoline was reported to cause most severe irritation (PATTY (5th, 2001); HSDB (2002)). Based on these documents, the substance was classified into Category 2.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,Cc1ccncc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.084I,J-GLOBAL,Cc1ccncc1,Train,1,2702,training
-"AU_HCIS:
-chlorobenzene
-
-JP_CHRIP:
-Chlorobenzene
-
-US_HSDB:
-CHLOROBENZENE","AU_HCIS:
-Benzene, chloro-
-
-JP_CHRIP:
-Benzene chloride
-Chlorobenzol
-Monochlorobenzene
-Phenyl chloride",108-90-7,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=919
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0116e.html
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/55","JP_CHRIP:
-Based on the evidence of ""moderate irritation"" from rabbit skin irritation tests (CERI-NITE Hazard Assessment No.82, 2005) and human reports (CERI-NITE Hazard Assessment No.82, 2005).",,"AU_HCIS, JP_CHRIP, US_HSDB",3,Clc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.869J,J-GLOBAL,Clc1ccccc1,Train,1,2702,training
-"AU_HCIS:
-cyclohexylamine
-
-JP_CHRIP:
-Cyclohexylamine
-
-KR_NCIS:
-Cyclohexylamine
-
-NZ_CCID:
-Cyclohexanamine","AU_HCIS:
-Cyclohexanamine
-aminocyclohexane
-aminohexahydrobenzene
-hexahydroaniline
-hexahydrobenzenamine
-
-JP_CHRIP:
-Aminocyclohexane
-Aminohexahydrobenzene
-Cyclohexanamine
-Cyclohexylamine
-Hexahydroaniline
-
-KR_NCIS:
-aminocyclohexane; hexahydroaniline
-
-NZ_CCID:
-1-Aminocyclohexane, 1-Cyclohexylamine, Aminocyclohexane, Aminohexahydrobenzene, Benzenamine, hexahydro-, Cyclohexylamine, Hexahydroaniline",108-91-8,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1117
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-2009e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1D8BF38F-A57B-4567-A15D-34AFEB23507D","JP_CHRIP:
-Open application to the rabbit skin resulted in a damage level of 7 on a scale of 1 to 10 within 24 hours, necrosis was seen (DFGMAK-Doc. 22 (2006)), and it is reported that this substance was found to be corrosive after 4-hour or 24-hour semi-occlusive application of 0.5 mL to the rabbit skin (DFGMAK-Doc. 22 (2006)). Furthermore, by 24-hour occlusive application of undiluted this substance to the guinea pig skin, edema, necrosis, and persistent eschars were observed, and severe irritation was shown (ACGIH (2001)). It was classified in Category 1 based on the above findings. Besides, pH is 11.5 (100 g/L).
-
-NZ_CCID:
-Skin Irritation
-R-PHRASE: R 34. [N-CLASS]
-UN CLASS: 8, PG II
-
-Eye Irritation
-SPECIES: Rabbit
-RESULT: One drop of 50% AQ soln, applied to conjuntival sac of rabbit eye, caused complete destruction of eye.
-REFERENCE SOURCE: [American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values, 4th ed., 1980. Cincinnati, Ohio: American Conference ofGovernmmental Industrial Hygienists, Inc., 1980. 113]**QC REVIEWED**[HSDB]
-R-PHRASE: R 34. [N-CLASS]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID",4,NC1CCCCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.870C,J-GLOBAL,NC1CCCCC1,Train,1,2702,training
-"JP_CHRIP:
-Cyclohexanol","JP_CHRIP:
-Cyclohexyl alcohol
-Hexahydrophenol
-Hexalin",108-93-0,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2070e.html,"JP_CHRIP:
-Based on a description that it is slightly irritating to human skin (ACGIH (7th, 2001), PATTY (6th, 2012)), and a description that this substance is irritating to the skin in short term exposure (HSDB (Access on June 2017)), it was considered to be an irritant, therefore, it was classified in Category 2. Besides, this substance is classified as ""Skin Irrit. 2, H315"" in the EU CLP classification (ECHA CL Inventory (Access on June 2017)). The category was changed by re-evaluating the contents of the information source.",,JP_CHRIP,1,OC1CCCCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.871A,J-GLOBAL,OC1CCCCC1,Train,1,2702,training
-"JP_CHRIP:
-Cyclohexanone","JP_CHRIP:
-Cyclohexyl ketone
-Ketohexamethylene
-Pimelic ketone",108-94-1,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2033e.html,"JP_CHRIP:
-Although there is a report that in a rabbit test with 2 samples of cyclohexanone, rabbits exhibited necrosis after occlusive application of one sample, then the sample was classified as corrosive (SIDS (access on Apr. 2009)), in an evaluation for corrosiveness in rabbits, no corrosion occurred in any rabbit (SIDS (access on Apr. 2009)). Application of the undiluted substance with open contact was non-irritating to rabbit skin (SIDS (access on Apr. 2009)). Additionally, although application of a 99% solution for 24-hour under occlusive conditions caused strong skin irritation, the effects slowly resolved and disappeared during a seven day period after application (PATTY (5th, 2001)). Based on these evidences of non-corrosive, the substance was classified into Category 2.",,JP_CHRIP,1,O=C1CCCCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.872J,J-GLOBAL,O=C1CCCCC1,Train,1,2702,training
-"JP_CHRIP:
-Phenol
-
-KR_NCIS:
-Phenol
-
-NZ_CCID:
-Phenol","JP_CHRIP:
-Benzenol
-Carbolic acid
-Hydroxybenzene
-Phenic acid
-phenol, pure
-
-KR_NCIS:
-Hydroxybenzene
-
-NZ_CCID:
-(Mono)hydroxybenzene, Benzenol, Carbolic acid, Oxybenzene, Phenic acid, Phenyl alcohol, Phenyl hydrate, Phenyl hydroxide, Phenylic acid, Phenylic alcohol",108-95-2,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2007.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3817198F-CE0B-4133-87EE-5EE65B03E140","JP_CHRIP:
-【分類根拠】
-（１）～（５）より区分1とした。
-
-【根拠データ】
-（１）本物質を含有する皮膚局所薬剤投与で刺激性皮膚炎の発生がみられ、皮膚への局所ばく露では、その部位に漂白作用又は紅疹が発生し、腐食や壊死に到る場合がある（CERI 有害性評価書 (2008)、MOE 初期評価 (2002)）。
-（２）本物質はヒトが経口及び経皮ばく露すると、皮膚、眼及び粘膜に対して強い刺激性を示す（CERI 有害性評価書 (2008)）。
-（３）本物質はウサギの皮膚に腐食性を示した（EPA Pesticides RED (2009)）。
-（４）ウサギ、ラット、マウス、ブタの眼又は皮膚に本物質を適用した結果、発赤、炎症、変色、発疹、潰瘍、壊死、腐食性を認めたとする報告がみられ、眼や皮膚に対する強い刺激性ないし腐食性を示すと考える（CERI 有害性評価書 (2008)、CEPA PSAR (2000)、EHC (1994)）。
-（５）In vitro 皮膚腐食性試験（OECD TG 431）において、皮膚腐食性がみられたとの報告がある（AICIS IMAP (2014)）。
-
-【参考データ等】
-（６）本物質は、平成8年労働省告示第33号（平成25年厚生労働省告示第316号により改正）において、労働基準法施行規則別表第一の二第四号1の厚生労働大臣が指定する単体たる化学物質及び化合物（合金を含む。）に「フェノール(別名石炭酸)」として指定されており、本物質にさらされる業務による、特定の症状又は障害を主たる症状又は障害とする疾病（頭痛、めまい、嘔吐等の自覚症状、皮膚障害、前眼部障害又は気道・肺障害）が、業務上の疾病として定められている。
-
-NZ_CCID:
-Skin Irritation
-REMARK: C ? 10 % T; R23/24/25-48/20/21/22-34-68
-3 % ? C < 10 % C ; Xn ; R20/21/22-34-68
-1 % ? C < 3 % Xn ; R36/38-68
-REFERENCE SOURCE: [ECB Annex]
-NOTE: Classified as corrosive based on R34 risk phrase.
-
-Eye Irritation
-REMARK: C ? 10 % T; R23/24/25-48/20/21/22-34-68
-3 % ? C < 10 % C ; Xn ; R20/21/22-34-68
-1 % ? C < 3 % Xn ; R36/38-68
-REFERENCE SOURCE: [ECB Annex]
-NOTE: Classified as corrosive based on R34 risk phrase.",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,Oc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.873H,J-GLOBAL,Oc1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-Thiophenol
-
-NZ_CCID:
-Thiophenol","JP_CHRIP:
-benzenethiol
-benzenethiol (synonym:thiophenol)
-Mercaptobenzene
-Phenyl mercaptan
-
-NZ_CCID:
-Benzenethiol, Mercaptobenzene, Phenol, thio-, Phenylmercaptan, Phenylthiol",108-98-5,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0038e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/548768DD-A9A4-492E-A3D3-E4010AA8B267","JP_CHRIP:
-Based on the description in the report on animal skin irritation tests (CERI Hazard Data 99-2 (2000)): ""severe irritation of the skin"" (though exposure duration is unknown). Also based on the description in PATTY (4th, 2000): ""Dermal application of the substance induced inflammatory responses, with effects resolving by 24-48 hours."" The substance is thus considered a skin irritant.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,"JP_CHRIP, NZ_CCID",2,Sc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.874F,J-GLOBAL,Sc1ccccc1,Train,1,2702,training
-"NZ_CCID:
-3-Pyridinol","NZ_CCID:
-3-hydroxypyridine",109-00-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/83FF8020-B797-474F-913A-75B48FEDD8BE,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CN=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/7971,PubChem,Oc1cccnc1,Train,1,2702,training
-"NZ_CCID:
-1-Methylpiperazine",,109-01-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6ED348DF-57B5-421A-9526-51D40A328D78,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data",,NZ_CCID,1,CN1CCNCC1,https://pubchem.ncbi.nlm.nih.gov/compound/53167,PubChem,CN1CCNCC1,Train,1,2702,training
-"NZ_CCID:
-Morpholine, 4-methyl-","NZ_CCID:
-4-methylmorpholine",109-02-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/891B9007-ED91-4267-B18A-5FF4BCA0B94E,"NZ_CCID:
-Skin Irritation
-UN CLASS: Sub Risk 8; PG II
-R PHRASE: R 34 [MSDS, ABCR Gmbh and Co.]
-[Chemfinder]
-Eye Irritation
-R-PHRASE: R 34. MSDS, ABCR Gmbh and Co.
-[Chemfinder]",,NZ_CCID,1,CN1CCOCC1,https://pubchem.ncbi.nlm.nih.gov/compound/7972,PubChem,CN1CCOCC1,Train,1,2702,training
-"NZ_CCID:
-2-Bromopyridine",,109-04-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E08BE440-653C-4C19-B783-06E92B736BA2,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=NC(=C1)Br,https://pubchem.ncbi.nlm.nih.gov/compound/7973,PubChem,Brc1ccccn1,Train,1,2702,training
-"JP_CHRIP:
-2-Methylpyridine (2-Picoline)","JP_CHRIP:
-2-methylpyridine
-2-Picoline
-alpha-Picoline
-o-Picoline
-Pyridine, 2-methyl-",109-06-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2021e.html,"JP_CHRIP:
-[Rationale for the Classification]
-Based on (1) and (2), it was classified in Category 1. Besides, information for subcategorization was not obtained.
-
-[Evidence Data]
-(1) There is a report that in a skin irritation test (U.S. 49 CFR 173.240) with rabbits (n=6), after a 4-hour occlusive application of this substance, ulceration or necrosis was observed in all animals (REACH registration dossier (Accessed Sept. 2018)).
-(2) Although the animal species is unknown, this substance is moderately to severely irritating, and signs of necrosis, ulceration and regeneration are reported (PATTY (6th, 2012)).",,JP_CHRIP,1,Cc1ccccn1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.087C,J-GLOBAL,Cc1ccccn1,Train,1,2702,training
-"NZ_CCID:
-2-Chloropyridine
-
-US_HSDB:
-2-Chloropyridine",,109-09-1,Cat 2,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BA170492-C9FB-489B-A087-3C54972CB71C
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8442","NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,"NZ_CCID, US_HSDB",2,C1=CC=NC(=C1)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7977,PubChem,Clc1ccccn1,Train,1,2702,training
-"EU_REACH:
-2-(chloromethyl)-4-methylquinazoline",,109113-72-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5361/7/4/2/?documentUUID=da6ee861-4d6c-48d7-8dbb-ae69aff4d045,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=NC(=NC2=CC=CC=C12)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/241518,PubChem,Cc1nc(CCl)nc2ccccc12,Train,1,2702,training
-"EU_REACH:
-tert-butyl 2-methylpropaneperoxoate",,109-13-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11987/7/4/2/?documentUUID=3211c910-debc-4194-acf9-fb39a6a268b8,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C(=O)OOC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/61023,PubChem,CC(C)C(=O)OOC(C)(C)C,Train,1,2702,training
-"NZ_CCID:
-2-Propenoic acid, 2-methyl-, 1,2-ethanediylbis(oxy-2,1-ethanediyl) ester","NZ_CCID:
-1,2-Bis(2-(methacryloyloxy)ethoxy)ethane, Ethylenebis(oxyethylene) methacrylate, Methacrylic acid, diester with triethylene glycol, NK ester 3G, TGM 3, TGM 3 PC, TGM 3S, TGM 3pc, Tedma, Triethylene glycol dimethacrylate",109-16-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/82B3A1CC-2145-48F0-B422-F5D60AD8BA9D,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 38 Irritating to skin. [Deproco UK Ltd. MSDS for Resiment base]
-
-Eye Irritation
-R-PHRASE: R 41 Risk of serious damage to eyes.
-[Deproco UK Ltd. MSDS for Resiment base]",,NZ_CCID,1,CC(=C)C(=O)OCCOCCOCCOC(=O)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/7979,PubChem,C=C(C)C(=O)OCCOCCOCCOC(=O)C(=C)C,Train,1,2702,training
-"EU_REACH:
-docosyl 4-hydroxybenzoate",,109236-76-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17137/7/4/2/?documentUUID=80544fc4-ffef-4ee8-859c-e3003de26978,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCCCCCCCOC(=O)C1=CC=C(C=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/13923401,PubChem,CCCCCCCCCCCCCCCCCCCCCCOC(=O)c1ccc(O)cc1,Train,1,2702,training
-"AU_HCIS:
-9-Octadecenamide, N-[3-(dimethylamino)propyl]-, (Z)-",,109-28-4,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6760,,,AU_HCIS,1,CCCCCCCC/C=C\CCCCCCCC(=O)NCCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6436063,PubChem,CCCCCCCC/C=C\CCCCCCCC(=O)NCCCN(C)C,Train,1,2702,training
-"EU_REACH:
-oxacycloheptadecan-2-one",,109-29-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24078/7/4/2/?documentUUID=6c9e667b-e071-43c6-9639-68604402dd91,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CCCCCCCC(=O)OCCCCCCC1,https://pubchem.ncbi.nlm.nih.gov/compound/7984,PubChem,O=C1CCCCCCCCCCCCCCCO1,Train,1,2702,training
-"EU_REACH:
-1,3-dibutyl-2-thiourea",,109-46-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26084/7/4/2/?documentUUID=06e11ce9-90d4-4319-9d3e-083179e35202,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCNC(=S)NCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/2723622,PubChem,CCCCNC(=S)NCCCC,Train,1,2702,training
-"JP_CHRIP:
-valeric acid
-
-NZ_CCID:
-Pentanoic acid","JP_CHRIP:
-1-Butanecarboxylic acid
-n-Pentanoic acid
-Propylacetic acid
-Valeric acid
-
-NZ_CCID:
-valeric acid",109-52-4,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0092e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DF30F573-B567-4F11-8DF4-D2F4F6318CCD","JP_CHRIP:
-Since there is a description that, valeric acid is a strong skin irritant in undiluted form (PATTY (5th, 2001)), and valeric acid is rated iC; R34 by EU (EU-AnnexI (accessed August 2008)), the substance was classified into Category 1. As relevant information, it is reported that using mixed isomers of valeric acid demonstrated some tissue necrosis in a 24h rabbit skin irritation assay (PATTY (5th, 2001)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CCCCC(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.504K,J-GLOBAL,CCCCC(=O)O,Train,1,2702,training
-"JP_CHRIP:
-Isobutyl vinyl ether",,109-53-5,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0093e.html,"JP_CHRIP:
-Based on a result of ""irritation"" in a rabbit Draize test by occluded dermal application for 2-hour (IUCLID (2000)), the substance was classified into Category 2. Although there is a result of ""grade 1 irritating"" in another rabbit test (PATTY (5th, 2001)), the result was not used as the basis of classification since the test method was not clear and the test was conducted in an earlier time (1943 - 1948).",,JP_CHRIP,1,CC(C)COC=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J48.642F,J-GLOBAL,C=COCC(C)C,Train,1,2702,training
-"AU_HCIS:
-3-aminopropyldimethylamine
-
-JP_CHRIP:
-3-aminopropyldimethylamine; N,N-dimethyl-1,3-diaminopropane
-
-NZ_CCID:
-3-Dimethylaminopropylamine","AU_HCIS:
-N,N-dimethyl-1,3-diaminopropane
-1,3-Propanediamine, N,N-dimethyl-
-
-JP_CHRIP:
-1,3-Propanediamine, N,N-dimethyl-
-1-Amino-3-dimethylaminopropane
-3-aminopropyldimethylamine
-N,N,-Dimethyl-1,3-propanediamine
-N,N-Dimethyl-1,3-diaminopropane
-
-NZ_CCID:
-N,N-Dimethyltrimethylenediamine",109-55-7,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=219
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0037e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6DBCCA85-778B-4CE8-9459-D51F291EE5FA","JP_CHRIP:
-There are several reports characterizing the substance as strongly irritating to corrosive in rabbit tests (IUCLID (2000), BUA report No. 197 (1996)). In addition, the substance was documented to cause necrosis as its dermal symptom (BUA report No. 197 (1996)). As such, the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CN(C)CCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J50.732F,J-GLOBAL,CN(C)CCCN,Train,1,2702,training
-"JP_CHRIP:
-Ethylene glycol monoisopropyl ether
-
-NZ_CCID:
-Ethanol, 2-(1-methylethoxy)-","JP_CHRIP:
-2-(1-Methoxyethoxy)-ethanol
-2-(isopropoxy)ethanol
-4-Methyl-3-oxa-1-pentanol
-EGiPE
-Ethanol, 2-(1-methylethoxy)-
-Ethylene glycol monoisopropyl ether
-Isopropyl glycol
-Isopropyl oxitol
-
-NZ_CCID:
-2-isopropoxyethanol, Dowanal eipat, Ethanol, 2-isopropoxy, Ethylene glycol isopropyl ether, Ethylene glycol monoisopropyl ether, Isopropyl oxitol",109-59-1,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2018e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6FF92AD8-B71C-4F94-923B-8825D93F9741","JP_CHRIP:
-There is a report that irritation was observed in a skin irritation test (EEC test method) in which this substance was applied to rabbits for 4 hours (SIDS (2011), ECETOC TR95 (2005)). In addition, skin primary irritation score, PII, by the Draize test method was 4.8 (24-hour application) (SIDS (2011), ECETOC TR 95 (2005)). From the above results, it was classified in Category 2.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Moderate
-REFERENCE SOURCE: [Prehled Prumyslove Toxikologie; Organicke Latky, Marhold, J., Praguet, Czechoslovakia, Avicenum, 1986 (-,627,1986)] [RTECS]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Mild
-REFERENCE SOURCE: [Prehled Prumyslove Toxikologie; Organicke Latky, Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 (-,627,1986)] [RTECS]",,"JP_CHRIP, NZ_CCID",2,CC(C)OCCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J82.343K,J-GLOBAL,CC(C)OCCO,Train,1,2702,training
-"JP_CHRIP:
-Propyl chloroformate
-
-KR_NCIS:
-n-Propyl chloroformate","JP_CHRIP:
-Carbonochloridic acid, propyl ester
-Formic acid, chloro-, propyl ester
-Propyl chlorocarbonate
-
-KR_NCIS:
-Carbonochloridic acid, propyl ester; CHLOROFORMATE, PROPYL; Formic acid, chloro-, propyl ester; n-Propyl chloroformate; Propyl chlorocarbonate; Propyl chloroformate",109-61-5,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2023e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP:
-[Rationale for the Classification]
-Based on (1), it was classified in Category 1B.
-
-[Evidence Data]
-(1) In a skin corrosion test in which 0.5 mL of this substance was applied to two rabbits, it was corrosive, and persistent erythema, edema and necrosis were observed after 15-minute and 20-hour exposure (SIDS (2012), REACH registration dossier (Access on July 2019)).
-
-[Reference Data, etc.]
-(2) In a skin irritation test in which 0.5 mL of this substance was applied to rabbits under occlusive application for 24 hours, the mean scores of intact skins were 7.8 at 24 hours and 8.0 at 72 hours, and the mean scores of abraded skins were 8.0 both at 24 hours and 72 hours (SIDS Dossier (2012)).
-(3) It was classified as ""Skin Corr. 1B (H314)"" in the EU CLP classification (EU CLP classification (Access on July 2019)).",,"JP_CHRIP, KR_NCIS",2,CCCOC(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.719A,J-GLOBAL,CCCOC(=O)Cl,Train,1,2702,training
-"NZ_CCID:
-1,3-Dibromopropane",,109-64-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AE477683-DF23-4D6B-8C0C-0C566B9104E3,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C(CBr)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/8001,PubChem,BrCCCBr,Train,1,2702,training
-"JP_CHRIP:
-n-Pentane","JP_CHRIP:
-Amyl hydride
-n-Pentane",109-66-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2096e.html,"JP_CHRIP:
-Based on a primary irritation index of 0.67 in a skin irritation test with rabbits (OECD TG 404, GLP-compliant), it was judged not to be irritating (SIDS (2010), EU-RAR (2003)). In addition, it is described that this substance is not irritating as a result of 24-hour semi-occlusive application to humans (GLP-compliant) (EU-RAR (2003)). On the other hand, it is described that by skin contact with this substance, degreasing and irritation occurred (OEL Documentations (Japan Society for Occupational Health (JSOH), 1987)), and that after skin application to volunteers, there was irritation such as pain, burning sensations and blisters, but no information on the test conditions and the degree of irritation were provided. Based on the above, the test result from the study according to the test guideline was adopted, and it was classified as ""Not classified.""",Provided,JP_CHRIP,1,CCCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J15I,J-GLOBAL,CCCCC,Train,1,2702,training
-"JP_CHRIP:
-1-chlorobutane; butyl chloride","JP_CHRIP:
-1-Chlorobutane
-n-Butyl chloride
-n-Propylcarbinyl chloride",109-69-3,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0164e.html,"JP_CHRIP:
-Skin irritation tests using rabbits (Open Draize tests and standard Draize tests) found that the substance is moderately to highly irritating (SIDS (1997)). Thus, it was classified into Category 2.",,JP_CHRIP,1,CCCCCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.435J,J-GLOBAL,CCCCCl,Train,1,2702,training
-"JP_CHRIP:
-n-Butylamine
-
-KR_NCIS:
-n-Butylamine
-
-NZ_CCID:
-1-Butanamine","JP_CHRIP:
-1-Aminobutane
-Monobutylamine
-n-Butylamine
-
-KR_NCIS:
-1-Butanamine; 1-aminobutane; Monobutylamine;Butan-1-amine
-
-NZ_CCID:
-1-Aminobutane, Mono-n-butylamine, Monobutylamine, Norvalamine, n-Butylamine",109-73-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2119e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/04BD6D13-E553-4012-8A6A-1E85A90D7E82","JP_CHRIP:
-There is a description that in a skin irritation test with guinea pigs, necrosis occurred after application (OEL Documentations (Japan Society For Occupational Health, 1994)). There is a description that in a skin irritation test (equivalent to OECD TG 404) with rabbits, in exposure time of 1 minute, immediate necrosis occurred, eschar was produced, and it showed corrosivity (SIDS(2016)). Therefore, this substance was classified in Category 1. Besides, this substance was classified as ""Skin Corr.1A, H314"" in the EU CLP classification (ECHA CL Inventory (Access on August 2017)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Guinea pig
-RESULT: N-Butylamine causes skin necrosis when applied at 0.5 ml/kg.
-REFERENCE SOURCE: [Peer Reviewed] Clayton, G.D., F.E. Clayton (eds.) Pattys Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994. 1105. [HSDB]
-R-PHRASE: R 35 Causes severe burns [IUCLID 2000]
-Eye Irritation
-SPECIES:
-RESULT: 10 and 50% v/v aqueous solutions and undiluted base produce severe eye burns in animals. The immediate eyen reaction is not appreciable altered by prolonged washing or attemps at neutralization when these are commenced within 15 sec after application
-REFERENCE SOURCE: BASF AG Ludwigshafen
-(81) Fasett D.W.: unpublished data; cited in: Pattys Industrial hyiene and Toxicology, Vol. IIB, 3155, (1982). [IUCLID 2000]
-R-PHRASE: R 35 Causes severe burns [IUCLID 2000]",Provided,"JP_CHRIP, KR_NCIS, NZ_CCID",3,CCCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.436H,J-GLOBAL,CCCCN,Train,1,2702,training
-"NZ_CCID:
-1,3-Diaminopropane","NZ_CCID:
-1,3-propylenediamine",109-76-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6FA76FE5-2F11-461E-AB95-6CB542DBF178,"NZ_CCID:
-Skin Irritation
-UN #2734 UN CLASS: 8 PG II
-Eye Irritation
-R PHRASE: R 35 [Company Data]
-UN #2734 UN CLASS: 8 PG II",,NZ_CCID,1,C(CN)CN,https://pubchem.ncbi.nlm.nih.gov/compound/428,PubChem,NCCCN,Train,1,2702,training
-"JP_CHRIP:
-2-methylaminoethanol
-
-NZ_CCID:
-2-(Methylamino) ethanol
-
-US_HSDB:
-2-Methylaminoethanol","JP_CHRIP:
-(2-Hydroxyethyl)methylamine
-2-(methylamino)ethanol
-2-methylaminoethanol
-Methylethylolamine
-Monomethylethanolamine
-
-NZ_CCID:
-2-methylaminoethanol",109-83-1,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0093e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C06F2FAD-F992-4DF1-992C-0526C97B09E2
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1128","JP_CHRIP:
-The classification is based on the results of ""being corrosive"" after application to skin of rabbits for 1 - 4 hours (IUCLID (2000)). As relevant notes, its pH is 13.4 (100 mL/L) (IUCLID (2000)), and it is rated C;R34 in EU classification (EU-Annex 1 (accessed August 2008)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,CNCCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.187H,J-GLOBAL,CNCCO,Train,1,2702,training
-"NZ_CCID:
-2-Methoxyethylamine",,109-85-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0C11A983-26C0-468A-B6A0-04611D6017CE,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,COCCN,https://pubchem.ncbi.nlm.nih.gov/compound/8018,PubChem,COCCN,Train,1,2702,training
-"EU_REACH:
-Isooctadecanoic acid, 1,1'-(2,2-dimethyl-1,3-propanediyl) ester",,109884-54-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17513/7/4/2/?documentUUID=5003d932-d1e9-490c-96ee-8adab9b79cf7,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCCCCCCCCCCC(=O)OCC(C)(C)COC(=O)CCCCCCCCCCCCCCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/10282874,PubChem,CC(C)CCCCCCCCCCCCCCC(=O)OCC(C)(C)COC(=O)CCCCCCCCCCCCCCC(C)C,Train,1,2702,training
-"JP_CHRIP:
-Diethylamine
-
-NZ_CCID:
-Ethanamine, N-ethyl-
-
-US_HSDB:
-DIETHYLAMINE","JP_CHRIP:
-Diethamine
-N,N-Diethylamine
-N-Ethylethanamine
-
-NZ_CCID:
-Diethylamine, N,N-Diethylamine, n-Ethylethanamine",109-89-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2042e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5819CBE2-8F54-4733-8F2D-4C4262A0407E
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/524","JP_CHRIP:
-There are multiple reports that it was corrosive in tests with rabbits (ACGIH (7th, 2013), IUCLID (2000)). Additionally, there is a description that this substance was severely irritating, and the skin of the contact site was damaged (OEL Documentations (Japan Society For Occupational Health (JSOH), 1989)). From the above, it was classified in Category 1. Besides, this substance was classified as ""Skin"" by ACGIH, as ""C:R35"" in the EU DSD classification, and as ""H314 Skin Corr. 1A"" in the EU CLP classification.
-
-NZ_CCID:
-Skin Irritation
-R-PHRASE: R 35 Causes severe burns. [IUCLID 2000]
-[N-Class]
-Eye Irritation
-SPECIES:
-RESULT: Contact with liquid can damage eyes, possibly permanently.
-REFERENCE SOURCE: [Lewis, R.J. Saxs Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996. 1147]**PEER REVIEWED** [HSDB]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,CCNCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J807I,J-GLOBAL,CCNCC,Train,1,2702,training
-"NZ_CCID:
-Ethyl isocyanate",,109-90-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5417DA8D-2420-482C-9DAB-8C1579E8585D,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Effects Below Cut Off
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCN=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/8022,PubChem,CCN=C=O,Train,1,2702,training
-"JP_CHRIP:
-Ethyl vinyl ether","JP_CHRIP:
-ethyl vinyl ether",109-92-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0048e.html,"JP_CHRIP:
-Based on reports of grade 1 (maximum grade 10) irritation after open application to the skin of rabbits (PATTY (5th, 2001)), and not irritating in another rabbit test (OECD TG404), the substance was classified as ""Not classified"".",Provided,JP_CHRIP,1,CCOC=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.440F,J-GLOBAL,C=COCC,Train,1,2702,training
-"AU_HCIS:
-Furan, tetrahydro-
-
-JP_CHRIP:
-Tetrahydrofuran
-
-NZ_CCID:
-Furan, tetrahydro-","AU_HCIS:
-Tetrahydrofuran
-
-JP_CHRIP:
-1,4-Epoxybutane
-Diethylene oxide
-Oxacyclopentane
-Tetramethylene oxide
-
-NZ_CCID:
-Butane, 1,4-epoxy-, Cyclotetramethylene oxide, Furanidine, Oxacyclopentane, Oxolane, Tetrahydrofuran",109-99-9,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=2207
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2084e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/146554BC-B3D9-4065-82E2-F68D8691C9C3","JP_CHRIP:
-[Rationale for the Classification]
-It was classified in Category 2 from (1)-(4). Besides, knowledge in humans was prioritized although it is also reported that it was not irritating in tests in rabbits or rats (7), (8). The category was revised by using new information sources.
-
-[Evidence Data]
-(1) It is reported that this substance is irritating to the skin, eye, and mucous membranes (ACGIH (2005), NICNAS IMAP (Accessed Dec. 2018), DFGOT (2004)).
-(2) It is reported that erythema, pain, and dryness of the skin occur when this substance contacts the eye or skin (Environmental Risk Assessment for Chemical Substances Vol. 7 (Ministry of the Environment, 2009)).
-(3) It is reported that irritation was observed after occlusive or open application of this substance on six humans (NICNAS IMAP (Accessed Dec. 2018))
-(4) There are multiple reports that it was irritating in skin irritation tests in rabbits, guinea pigs, rats, or mice (SIAR (2000), Environmental Risk Assessment for Chemical Substances Vol. 7 (Ministry of the Environment, 2009), NICNAS IMAP (Accessed Dec. 2018)).
-
-[Reference Data, etc.]
-(5) In the announcement No. 33 of the Ministry of Labour (1996) (revised by the announcement No. 316 of the Ministry of Health, Labour and Welfare, 2013), this substance was designated as ""tetrahydrofuran"" in Simple chemical substances or compounds designated by the Minister of Health, Labour and Welfare based on Appended Table 1-2, (iv) 1 of the Ordinance for Enforcement of the Labor Standards Act, and a disease principally having specific symptoms and disorders (subjective symptoms such as headaches, dizziness, and vomiting or skin disorders) due to work involving exposure to this substance was designated as an occupational disease by the Minister of Health, Labour and Welfare.
-(6) In the notice No. 0811001 issued by Director of Labour Standards Bureau, the Ministry of Labour (2003), this substance was designated as ""tetrahydrofuran"" among hazardous substances for which installation of protective equipment to prevent skin disorders is mandated in Article 594 in the Industrial Safety and Health Regulations.
-(7) It is reported that in a skin irritation test with rabbits (n = 6), after 72-hour occlusive application of this substance, PII: 1.93, erythema score: 0.75, and edema score: 0.9 were obtained after 72 hours, and it was not irritating (ACGIH (2005), REACH registration dossier (Accessed Dec. 2018)).
-(8) It is reported that in an acute dermal toxicity test with rats (OECD TG402, n = 5 (males), 5 (females)), after 24-hour semi-occlusive application of this substance (purity > 99.8%), no erythema or edema was found (REACH registration dossier (Accessed Dec. 2018)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: THF was irritating to rabbits when applied topically in aq soln exceeding 20% concn.
-REFERENCE SOURCE:[Peer Reviewed] [American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I,II, III. Cincinnati, OH: ACGIH, 1991. 1517] [HSDB]
-Eye Irritation
-SPECIES:
-RESULT: Very irritating
-REFERENCE SOURCE: [NTP]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,C1CCOC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.878I,J-GLOBAL,C1CCOC1,Train,1,2702,training
-"EU_REACH:
-2-({3-[bis(cyanomethyl)amino]propyl}(cyanomethyl)amino)acetonitrile",,110057-45-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/4332/7/4/2/?documentUUID=8313cf05-f1e8-4098-8ad7-0ce8f2f0a05f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CN(CC#N)CC#N)CN(CC#N)CC#N,https://pubchem.ncbi.nlm.nih.gov/compound/314171,PubChem,N#CCN(CC#N)CCCN(CC#N)CC#N,Train,1,2702,training
-"EU_REACH:
-succinic acid",,110-15-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15265/7/4/2/?documentUUID=42f74ea6-278b-4aac-bcbc-20d60bbcf2da,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CC(=O)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/1110,PubChem,O=C(O)CCC(=O)O,Train,1,2702,training
-"JP_CHRIP:
-N,N,N',N'-tetramethylethylenediamine
-
-NZ_CCID:
-1,2-Ethanediamine, N,N,N',N'-tetramethyl-","JP_CHRIP:
-N,N,N',N'-Tetramethyl-1,2-ethanediamine
-
-NZ_CCID:
-Propamine D, Temed, Tetrameen, Tetramethyl ethylene diamine, Tetramethyldiaminoethane",110-18-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0167e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/22193BD3-92A5-4F59-817B-BD1499249582","JP_CHRIP:
-In skin irritation tests using rabbits (HSDB (2002)), 1-hour and 4-hour applications resulted in full-thickness necrosis or ulceration and ecchymoses; and the necrosis persisted for 14 days. Based on this information, the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Substance appears to be a corrosive with irreversible effects at day 14
-REFERENCE SOURCE: Union Carbide Corp; Catalyst C-271: Acute Toxicity and Irritancy Testing Using the Rat (Peroral & Inhalation Toxicity) and the Rabbit (Cutaneous & Eye Tests); 08/24/93; EPA Document No. 89-930000176; Fiche No. OTS0538306] **UNREVIEWED** [HSDB]
-
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Slight to moderate corneal opacity and iritis, and severe conjunctival irritation were common to all treated eyes, the corneal injury with hemorrhaging of the nictitating membrane developing by the 24th hour observation. A purulent ocular discharge was noted in 3/4 rabbits by 72 hours post-instillation. By Day 14, 2/4 treated rabbit eyes were free of all irritative signs. The remaining minor corneal vascularization and conjunctival irritation in 1 and 2 rabbits, respectively, persisted to Day 21
-REFERENCE SOURCE: Union Carbide Corp; Catalyst C-271: Acute Toxicity and Irritancy Testing Using the Rat (Peroral & Inhalation Toxicity) and the Rabbit (Cutaneous & Eye Tests); 08/24/93; EPA Document No. 89-930000176; Fiche No. OTS0538306] **UNREVIEWED** [HSDB]
-EXPERT JUDGEMENT: Appears to be a eye corrosive as standard test uses 0.1 ml not the 0.01 ml used in this test. Therefore the effects are expected to be enhanced so classified as an eye corrosive rather than an eye irritant",,"JP_CHRIP, NZ_CCID",2,CN(C)CCN(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.745K,J-GLOBAL,CN(C)CCN(C)C,Train,1,2702,training
-"ChemSkin:
-Isopropyl myristate
-
-EU_REACH:
-isopropyl myristate",,110-27-0,NC,"ChemSkin: https://doi.org/10.3390/toxics9110314
-EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16077/7/4/2/?documentUUID=ced703af-f120-4c1f-bea9-59e0b6a33326","ChemSkin:
-Experimental study (OECD TG 404)
-
-EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,"ChemSkin, EU_REACH",2,CCCCCCCCCCCCCC(=O)OC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/8042,PubChem,CCCCCCCCCCCCCC(=O)OC(C)C,Train,1,2702,training
-"NZ_CCID:
-Decanoic acid, methyl ester",,110-42-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7D584DA6-C6CF-4215-9900-9A7F3A23F30B,"NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Irritating
-REFERENCE SOURCE: [IUCLID]",,NZ_CCID,1,CCCCCCCCCC(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/8050,PubChem,CCCCCCCCCC(=O)OC,Train,1,2702,training
-"NZ_CCID:
-1,4-Dibromobutane",,110-52-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B4ECC492-255C-4565-A5CE-F7419051C188,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(CCBr)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/8056,PubChem,BrCCCCBr,Train,1,2702,training
-"NZ_CCID:
-1-Bromopentane",,110-53-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/95EED0D6-113C-4AF7-9853-007B6FC6858B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CCCCCBr,https://pubchem.ncbi.nlm.nih.gov/compound/8057,PubChem,CCCCCBr,Train,1,2702,training
-"AU_HCIS:
-n-hexane
-
-JP_CHRIP:
-n-Hexane","JP_CHRIP:
-Hexyl hydride
-n-Hexane",110-54-3,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=2402
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2048e.html","JP_CHRIP:
-Slight irritation of rabbit skin was observed after semi-occlusive application for 24-hour (DFGOT vol. 14 (2000)). For humans, after occlusive application to the skin for 1 to 5-hour, erythema was observed. After 5-hour, formation of blisters was observed. The application of 1.5 mL to the skin of the forearm caused a stabbing and burning sensation and transient erythema (DFGOT vol. 14 (2000)). Additionally, the substance is classified into Xi; R38 in EU classification (EU-Annex I (access on July 2005)). Based on these data, the substance was classified into Category 2.",,"AU_HCIS, JP_CHRIP",2,CCCCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.977A,J-GLOBAL,CCCCCC,Train,1,2702,training
-"EU_REACH:
-2-methyl-4,6-bis[(octylsulfanyl)methyl]phenol",,110553-27-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13350/7/4/2/?documentUUID=c5664c74-61e4-4751-a365-e08a272f853b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCSCC1=CC(=C(C(=C1)C)O)CSCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/113646,PubChem,CCCCCCCCSCc1cc(C)c(O)c(CSCCCCCCCC)c1,Train,1,2702,training
-"NZ_CCID:
-Amylamine","NZ_CCID:
-N-Pentylamine",110-58-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CCE3EABA-1E70-4D06-A6C1-73A681F66700,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/8060,PubChem,CCCCCN,Train,1,2702,training
-"NZ_CCID:
-1,4-Diaminobutane","NZ_CCID:
-putrescine",110-60-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6FB495BD-EFEE-4F4A-82C5-8BDAD63297AB,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(CCN)CN,https://pubchem.ncbi.nlm.nih.gov/compound/1045,PubChem,NCCCCN,Train,1,2702,training
-"JP_CHRIP:
-2-Butyne-1,4-diol
-
-KR_NCIS:
-2-Butyne-1,4-diol
-
-NZ_CCID:
-2-Butyne-1,4-diol","JP_CHRIP:
-1,4-Butynediol
-1,4-Dihydroxy-2-butyne
-2-Butynediol
-But-2-yne-1,4-diol
-
-KR_NCIS:
-Butynediol; But-2-yne-1,4-diol
-
-NZ_CCID:
-2-BUTYNEDIOL, BIS(HYDROXYMETHYL)ACETYLENE, BUTYNEDIOL",110-65-6,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0026e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B3754F63-18D5-46D6-8120-81E735B4679C","JP_CHRIP:
-In the rabbit test (OECD TG 404) treated 6 animals with 0.5 g for 4 hours, severe erythema and severe edema within 24 hours, and necrosis within 6 days were noted in all animals. Based on the information, the substance was classified as Category 1. The substance was classified as ""R34"" in the EU classification (EU-Annex I (Access on May 2010))
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Irritating
-REFERENCE SOURCE: BASF AG Ludwigshafen 73)BASF AG, Abteilung Toxikologie, unveroeffentlichte Untersuchung (XXIII/126), 31.12.1973. [ICULID 2000]
-R-PHRASE: R 34 Causes burns. [ECB]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Moderate
-REFERENCE SOURCE: Journal of Applied Toxicology, Vol. 12, No. 2, pages 113-115, 7 references, 1992. [toxnet]",Provided,"JP_CHRIP, KR_NCIS, NZ_CCID",3,OCC#CCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.098I,J-GLOBAL,OCC#CCO,Train,1,2702,training
-"AU_HCIS:
-Phenol, isononyl-
-
-KR_NCIS:
-Isononylphenol",,11066-49-2,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5792
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,"AU_HCIS, KR_NCIS",2,CC(C)CCCCCCC1=CC=CC=C1O,https://pubchem.ncbi.nlm.nih.gov/compound/119757,PubChem,CC(C)CCCCCCc1ccccc1O,Train,1,2702,training
-"NZ_CCID:
-Butylmethylamine","NZ_CCID:
-N-Methylbutylamine, N-butylmethylamine",110-68-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C445C8AD-F04B-4CB8-948C-F49B51562D96,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCNC,https://pubchem.ncbi.nlm.nih.gov/compound/8068,PubChem,CCCCNC,Train,1,2702,training
-"AU_HCIS:
-1,2-dimethoxyethane
-
-KR_NCIS:
-Ethylene glycol dimethyl ether","AU_HCIS:
-ethylene glycol dimethyl ether
-EGDME
-Ethane, 1,2-dimethoxy-",110-71-4,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1409
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,"AU_HCIS, KR_NCIS",2,COCCOC,https://pubchem.ncbi.nlm.nih.gov/compound/8071,PubChem,COCCOC,Train,1,2702,training
-"NZ_CCID:
-2-(Ethylamino) ethanol",,110-73-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D4C3AAF5-BE47-48D2-90B9-62EEFF41DECA,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCNCCO,https://pubchem.ncbi.nlm.nih.gov/compound/8072,PubChem,CCNCCO,Train,1,2702,training
-"JP_CHRIP:
-Cyclohexane
-
-KR_NCIS:
-Hexahydrobenzene; Cyclohexane
-
-US_HSDB:
-CYCLOHEXANE","JP_CHRIP:
-Hexahydrobenzene
-Hexamethylene
-Hexanaphthene",110-82-7,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-2027e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/60","JP_CHRIP:
-It is described that it was irritating to the skin in rabbits and humans (DFGOT vol. 13 (1999), EU-RAR (2004), ACGIH (7th, 2002), ICSC (J) (1994)). It is described that repeated administration to rabbits produced cracked skin and bleeding, but these disappeared one week after the administration (DFGOT vol. 13 (1999)), and the 1-hour application of the undiluted substance to humans produced erythema and wheal formation (EU-RAR (2004)), which are also thought to be reversible disorder. It was classified in Category 2 from the above data.",,"JP_CHRIP, KR_NCIS, US_HSDB",3,C1CCCCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.882G,J-GLOBAL,C1CCCCC1,Train,1,2702,training
-"AU_HCIS:
-piperazine
-
-JP_CHRIP:
-Piperazine
-
-NZ_CCID:
-Piperazine","AU_HCIS:
-[liquid]
-
-JP_CHRIP:
-1,4-Diazacyclohexane
-1,4-Diethylenediamine
-Antiren
-Diethyleneimine
-Hexahydropirazine",110-85-0,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3552
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-meti-0015e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7CAEF84F-55E5-4F70-833F-89CA4277EB87","JP_CHRIP:
-There is a report that in a skin irritation test (OECD TG404) with rabbits, as a result of a semi-occlusive application of this substance (50% aqueous solution) for 4 hours, severe erythema and necrosis were observed (EU-RAR (2005)). In addition, there is a report that in another skin irritation test with rats or mice, necrosis on the application site was observed after a 4 hour-application of this substance (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), DFGOT Vol. 9 (1998)). From the above, it was classified in Category 1. Besides, this substance was classified as ""Skin. Corr. 1B H314"" in EU CLP classification (ECHA CL Inventory (Access on September 2015)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Corrosive
-REFERENCE SOURCE: (BASF, 1984). Prepared by the National Chemicals Inspectorate, Sweden. Based on the EU Risk Assessment Report (RAR) on piperazine. [ECB]
-R PHRASE: R 34 [N-Class)
-Eye Irritation
-R PHRASE: R 34 [N-Class)",Provided,"AU_HCIS, JP_CHRIP, NZ_CCID",3,C1CNCCN1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.981J,J-GLOBAL,C1CNCCN1,Train,1,2702,training
-"NZ_CCID:
-2H-Pyran, 3,4-dihydro-","NZ_CCID:
-2,3-Dihydropyran, 3,4-Dihydro-2H-pyran, 5,6-Dihydro-4H-pyran",110-87-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BBB43380-2825-4740-8BE9-57CE4A592849,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 38 Irritating to Skin. [MERCK]
-Eye Irritation
-R36 - Irritating to Eyes
-[MERCK]",,NZ_CCID,1,C1CC=COC1,https://pubchem.ncbi.nlm.nih.gov/compound/8080,PubChem,C1=COCCC1,Train,1,2702,training
-"AU_HCIS:
-piperidine
-
-JP_CHRIP:
-piperidine
-
-NZ_CCID:
-Piperidine","JP_CHRIP:
-Azacyclohexane
-Hexahydropyridine
-Pentamethyleneimine
-
-NZ_CCID:
-Azacyclohexane, Cyclopentimine, Cypentil, Hexahydropyridine, Hexazane, Pentamethyleneimine, Pentamethylenimine, Perhydropyridine, Pyridine, hexahydro-",110-89-4,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3555
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0169e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/56281F0D-7408-4FB6-A95C-3022A12B8D5E","JP_CHRIP:
-In the study using 6 rabbits, necrosis was observed in all test animals (PATTY (5th, 2001)). In other animal tests, the substance was reported to have a corrosive effect (HSDB (2008)). Furthermore, in human accident cases, severe epithelial damage and chemical burns were reported with the substance in contact with skin for no longer than 3 minutes (PATTY (5th, 2001)). Based on this information on animals and humans, the substance was classified into Category 1. Its pH = 12.6 (20degC, 100 g/L) (GESTIS (accessed in November 2008)) and it is rated as R34 in the EU classification.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Human
-RESULT: In an accidental case of skin exposure, third degree burns developed after only 3 min of skin contact.
-REFERENCE SOURCE: [Peer Reviewed] [Snyder, R. (ed.). Ethyl Brownings Toxicity and Metabolism of Industrial Solvents. 2nd ed. Volume II: Nitrogen and Phosphorus Solvents. Amsterdam-New York-Oxford: Elsevier, 1990. 255] [HSDB]
-UN CLASS: 8 PG I
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Severe damage with permanent corneal injury.
-REFERENCE SOURCE: [Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963. 2197]**PEER REVIEWED** [HSDB]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,C1CCNCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.884C,J-GLOBAL,C1CCNCC1,Train,1,2702,training
-"AU_HCIS:
-morpholine
-
-EU_REACH:
-morpholine
-
-JP_CHRIP:
-Morpholine
-
-NZ_CCID:
-Morpholine","JP_CHRIP:
-Diethylene oximide
-Tetrahydro-1,4-oxazine
-tetrahydro-1,4-oxazine [synonym:morpholine]
-
-NZ_CCID:
-1-Oxa-4-azacyclohexane, 2H-1,4-Oxazine, tetrahydro-, 4H-1,4-Oxazine, tetrahydro-, Diethylene imidoxide, Diethylene oximide, Diethyleneimide oxide, Diethylenimide oxide, Drewamine, Tetrahydro-1,4-oxazine, Tetrahydro-p-oxazine, p-Isoxazine, tetrahydro-",110-91-8,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3091
-EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13364/7/4/2/?documentUUID=b5fbf61e-b34d-454d-90ce-c03f3e99c9d0
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2042e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E3D2089C-2B17-4F66-B6D3-AD8AA873BB6E","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-Based on the description that this substance is corrosive to the human skin (SIDS (2015)), and multiple test reports that necrosis occurred due to the application of this substance in skin irritation tests with rabbits (EHC 179 (1996), IARC 47 (1989), ACGIH (7th, 2001), PATTY (6th, 2012), SIDS (2015)), it was classified in Category 1. Besides, in the EU CLP classification, this substance was classified as ""Skin Corr. 1B"" (ECHA CL Inventory (Access on June 2017)).
-
-NZ_CCID:
-Skin Irritation
-UNCLASS: UN PG 1
-R PHRASE: R 34 [iuclid 2000]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Severe
-REFERENCE SOURCE: American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1-1918- (29,1363,1946) [RTECS]",Provided,"AU_HCIS, EU_REACH, JP_CHRIP, NZ_CCID",4,C1COCCN1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.453H,J-GLOBAL,C1COCCN1,Train,1,2702,training
-"EU_REACH:
-N,N,N',N'-tetramethyltrimethylenediamine",,110-95-2,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5408/7/4/2/?documentUUID=cea8a7fd-d9ff-4c30-97f6-e89ccafc62d6,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C)CCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/8084,PubChem,CN(C)CCCN(C)C,Test,1,2702,training
-"NZ_CCID:
-1-Propanamine, 2-methyl-N-(2-methylpropyl)-","NZ_CCID:
-Diisobutylamine",110-96-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E0FADC70-DC8C-43B3-B549-0A727A41A55F,"NZ_CCID:
-Skin Irritation
-REMARK: UN 2361 Class 3.0;Sub Risk 8; PG III
-Eye Irritation
-SPECIES:
-RESULT: Irritating
-REFERENCE SOURCE: Review by Thomas (1990) Ethyl Brownings Toxicity and Metabolism of Industrial Solvents.
-REMARK: UN has classified as sub-risk 8 - corrosive.
-EXPERT JUDGEMENT: This is probably a severe eye irritant, like many other secondary aliphatic amines.",,NZ_CCID,1,CC(C)CNCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/8085,PubChem,CC(C)CNCC(C)C,Train,1,2702,training
-"JP_CHRIP:
-1,1'-iminodipropan-2-ol; di-isopropanolamine","JP_CHRIP:
-1,1'-Iminodi-2-propanol
-Bis(2-propanol) amine
-diisopropanolamine
-DIPA",110-97-4,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0170e.html,"JP_CHRIP:
-There are several reports that the application of the substance to abraded or intact sites of rabbit skin caused moderate or slight hyperemia (IUCLID (2000); HSDB (2006)), or the application to abraded sites caused moderate denaturation (IUCLID (2000); HSDB (2006)). Furthermore, in Draize tests using rabbits, application of undiluted test substance to intact sites on the abdomens of rabbits caused irreversible, severe necrosis at several sites (HSDB (2006)). Thus the substance was classified into Category 1.",,JP_CHRIP,1,CC(O)CNCC(C)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.102K,J-GLOBAL,CC(O)CNCC(C)O,Train,1,2702,training
-"NZ_CCID:
-Octanoic acid, methyl ester","NZ_CCID:
-Capric acid methyl ester Capric acid methyl ester, Decanoic acid, methyl ester, Methyl caprate",111-11-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/41BFC2B7-EC00-4758-9711-32FE0E586E21,"NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Irritating
-REFERENCE SOURCE: Henkel KGaA Duesseldor [IUCLID]
-REMARK: Test Substance: Analogy! Fatty acid C6-10 methylester was tested.
-SPECIES: Human
-RESULT: Irritating
-REFERENCE SOURCE: Henkel KGaA Duesseldor [IUCLID]
-REMARK: Test Substance: Analogy! Fatty acid C6-10 methylester was tested.",,NZ_CCID,1,CCCCCCCC(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/8091,PubChem,CCCCCCCC(=O)OC,Train,1,2702,training
-"JP_CHRIP:
-heptanoic acid
-
-NZ_CCID:
-Heptanoic acid","JP_CHRIP:
-Enanthic acid
-n-Heptoic acid
-n-Heptylic acid",111-14-8,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0171e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AB329A3C-A115-48A2-9A1B-217426CCA37F","JP_CHRIP:
-Rabbits were exposed to the substance for 4 hours, and as a result, treated subjects, as a whole, were graded 5.6 on a scale of 1 to 8 of the primary irritation index, indicating that the substance is corrosive (Patty 5th, 2001). Based on these results, the substance was classified into Category 1. It is rated as R34 in the EU classification (equivalent to Category 1B or 1C) (EU-Annex 1, accessed in November 2008).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CCCCCCC(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.985B,J-GLOBAL,CCCCCCC(=O)O,Train,1,2702,training
-"EU_REACH:
-[6-(dimethylamino)hexyl]dimethylamine",,111-18-2,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11920/7/4/2/?documentUUID=abaa9300-517a-409f-854a-5cf660535b57,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C)CCCCCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/8097,PubChem,CN(C)CCCCCCN(C)C,Train,1,2702,training
-"NZ_CCID:
-Sebacoyl dichloride",,111-19-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/667545F7-4B26-4C4C-9D45-F80090947A96,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(CCCCC(=O)Cl)CCCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/66072,PubChem,O=C(Cl)CCCCCCCCC(=O)Cl,Train,1,2702,training
-"NZ_CCID:
-1,5-Dibromopentane",,111-24-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0906D2F5-F360-4873-995B-BADA27413948,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(CCBr)CCBr,https://pubchem.ncbi.nlm.nih.gov/compound/8100,PubChem,BrCCCCCBr,Train,1,2702,training
-"NZ_CCID:
-1-Bromohexane",,111-25-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E7172CCB-A5F1-4D6E-99C6-CEC61495AD39,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CCCCCCBr,https://pubchem.ncbi.nlm.nih.gov/compound/8101,PubChem,CCCCCCBr,Train,1,2702,training
-"EU_REACH:
-tetraethenylsilane",,1112-55-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24943/7/4/2/?documentUUID=5dd459b7-008e-4a43-a735-65d92c8bd0d5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=C[Si](C=C)(C=C)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/66188,PubChem,C=C[Si](C=C)(C=C)C=C,Train,1,2702,training
-"NZ_CCID:
-Hexylamine
-
-US_HSDB:
-1-Hexylamine",,111-26-2,Cat 1,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D7A42524-7B09-4069-BC4C-81B932E204B0
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8444","NZ_CCID:
-Skin Irritation
-R PHRASE: R 35 [Company Data]
-Eye Irritation
-R PHRASE: R 35 [Company Data]",,"NZ_CCID, US_HSDB",2,CCCCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/8102,PubChem,CCCCCCN,Train,1,2702,training
-"JP_CHRIP:
-Glutaraldehyde
-
-KR_NCIS:
-Glutaraldehyde
-
-NZ_CCID:
-Pentanedial, (glutaraldehyde)
-
-US_HSDB:
-Glutaraldehyde","JP_CHRIP:
-Glutaraldehyde
-1,5-pentanedial
-1,5-Pentanedial (50% solution)
-Glutaral
-glutardialdehyde
-Glutaric dialdehyde
-Pentanedial
-
-KR_NCIS:
-1,5-pentanedial; 1,3-diformylpropane; Glutaral; Glutardialdehyde; Glutaric dialdehyde
-
-NZ_CCID:
-1,5-Pentanedial, Glutaral, Glutaraldehyde, Glutardialdehyde, Glutaric acid dialdehyde, Glutaric dialdehyde, Pentanedial",111-30-8,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2008.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B4DEED8F-54FD-4CBB-A0B9-656446DBE6FB
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/949","JP_CHRIP:
-【分類根拠】
-（１）～（４）より、区分1Bとした。
-
-【根拠データ】
-（１）本物質は実験動物の皮膚に対して25％以上の水溶液で刺激性を示す。ヒトの皮膚に付着すると、発赤、水疱を生じるほか、のどや鼻粘膜への刺激症状がみられる。皮膚炎等の防止策として厚生労働省は作業環境気中濃度の最大値の目安を0.05 ppm に設定している（厚労省 リスク評価書 (2015)）。
-（２）ウサギ（n=6）を用いた皮膚刺激性試験（OECD TG 404、GLP、4時間適用、10日観察）において、適用後24/48/72h後の紅斑スコアの平均は2.8、浮腫スコアの平均は2.6であり、10日後の観察でも壊死と剥離が認められ回復性はみられなかった。並行して実施した1時間ばく露群ではばく露後に生存した5例のうち2例で壊死、4例で皮膚剥離がみられ、3分ばく露群では1例で軽度の紅斑がみられたとの報告がある（ECHA RAC Opinion (2014)、CLH Report (2013)）。
-（３）ウサギ（n=4）を用いた皮膚刺激性試験（4時間適用、8日観察）において、50％水溶液を適用した場合、8日後に壊死、紅斑及び浮腫が認められ、非可逆的な影響であった。また、ウサギ（n=2）を用いた皮膚刺激性試験（50％水溶液を1時間適用、8日観察）では8日後に紅斑及び浮腫を伴う重度の痂皮脱落が認められ、回復性はみられず、ウサギを用いた皮膚刺激性試験（50％水溶液を3分間適用、8日観察）では浮腫はみられず、8日後に痂皮がみられたとの報告がある（ECHA RAC Opinion (2014)、CLH Report (2013)）。
-（４）ウサギ（n=5）を用いた皮膚刺激性試験（OECD TG 404相当、半閉塞）において、24％溶液適用群1例について、3分間適用し24時間観察したところ腐食性はみられなかったが、1時間または4時間適用し24時間観察したところ腐食性がみられた。15％溶液適用群1例について、3分間または1時間適用し72時間観察したところ腐食性はみられなかったが、4時間適用し72時間観察したところ腐食性がみられた。4％溶液適用群3例について、4時間適用し14日間観察したところ重度の浮腫がみられた（紅斑・痂皮スコア：3.3/2.7/2.7、浮腫スコア：4/2/3）との報告がある（REACH登録情報 （Accessed July 2021)）。
-
-【参考データ等】
-（５）本物質は、平成8年労働省告示第33号（平成25年厚生労働省告示第316号により改正）において、労働基準法施行規則別表第一の二第四号1の厚生労働大臣が指定する単体たる化学物質及び化合物（合金を含む。）に「グルタルアルデヒド」として指定されており、本物質にさらされる業務による、特定の症状又は障害を主たる症状又は障害とする疾病（皮膚障害、前眼部障害又は気道障害）が、業務上の疾病として定められている。
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [IUCLID 2000] [NCLASS]
-
-Eye Irritation
-SPECIES:
-RESULT: A 0.1% solution of GA is not irritating to the eye; the threshold for conjunctival irritation is 0.2% and for corneal injury it is 1.0%. Eye injury is moderate at 2% and severe at > or =5%.
-REFERENCE SOURCE: Ballantyne B, Jordan SL. Applied Toxicology Group, Union Carbide Corporation, 39 Old Ridgebury Road, Danbury, CT 06817-0001, USA. J Appl Toxicol 2001 Mar-Apr;21(2):131-51 [MEDLINE]
-SPECIES: Rabbit
-RESULT: ...A 25% aq solution on rabbit eyes, caused severe injury, graded 9 on a scale of 10. A 1% solution quickly abolishes the b-wave of the rabbit retina in vitro.
-REFERENCE SOURCE: Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986. 462 **PEER REVIEWED** [HSDB]",Provided,"JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",4,O=CCCCC=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.454F,J-GLOBAL,O=CCCCC=O,Train,1,2702,training
-"JP_CHRIP:
-diammonium oxalate","JP_CHRIP:
-Ethanedioic acid, diammonium salt",1113-38-8,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-1244e.html,"JP_CHRIP:
-Since ICSC (J) (1995), HSFS (1987), and HSDB (2002) had description (bubble, an ulcer, serious burned) which indicates skin irritation in the human impact, it was set as Category 2.",,JP_CHRIP,1,[N+]OC(=O)C(=O)O[N+],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J558D,J-GLOBAL,[N+]OC(=O)C(=O)O[N+],Train,1,2702,training
-"JP_CHRIP:
-1-Isocyanatobutane","JP_CHRIP:
-1-Isocyanatobutane",111-36-4,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0006e.html,"JP_CHRIP:
-After occlusive application of 0.5 mL of an undiluted test substance to rabbit ears for 15 or 30 minutes, effects became more serious and the skin was perforated in 1 to 2 days. Surface skin scaling was observed at the end of observation period of 7 days.
-On the basis of the evaluation as ""highly corrosive"" (SIDS (2005)), it was classified in Category 1.",,JP_CHRIP,1,CCCCN=C=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J36.974H,J-GLOBAL,CCCCN=C=O,Train,1,2702,training
-"AU_HCIS:
-1,2-Ethanediamine, N-(2-aminoethyl)-
-
-JP_CHRIP:
-N-(2-Aminoethyl)-1,2-ethanediamine; Diethylenetriamine
-
-NZ_CCID:
-Diethylene triamine","AU_HCIS:
-diethylenetriamine
-DETA
-ancamine DETA
-3-azapentane-1.5-diamine
-2,2'-iminobis(ethanamine)
-
-JP_CHRIP:
-3-Azapentane-1,5-diamine
-Bis(2-aminoethyl)amine
-DETA
-N-(2-Aminoethyl)-1,2-ethanediamine
-
-NZ_CCID:
-1,2-Ethanediamine, N-(2-aminoethyl)-, 1,4,7-Triazaheptane, 1,5-Diamino-3-azapentane, 2-(2-Aminoethylamino)ethylamine, 3-Azapentane-1,5-diamine, Bis(2-aminoethyl)amine, Diethylenetriamine, N,N-Bis(2-aminoethyl)amine, N-(2-Aminoethyl)-1,2-ethanediamine",111-40-0,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=7
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-2028e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EB07CFC3-E1E7-4577-894F-87F4DD9E9498","JP_CHRIP:
-Strong corrosivity or corrosivity is described as health effects in humans (Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)) and the results of skin irritation tests with rabbits (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), SIDS (2002)). Furthermore, this substance is classified in ""C; R34"" in EU DSD classification and ""Skin Corr. 1B H314"" in EU CLP classification. It was classified in Category 1 based on the above information.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Highly corrosive.
-REFERENCE SOURCE: Dow Benelux N. V. Terneuzen (55)(55) Anonym.: Report of Union Carbide Corporation, 27.6.1983 [IUCLID 2000]
-REMARK: EC Classification: Highly corrosive (causes severe burns)
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Highly corrosive
-REFERENCE SOURCE: Dow Benelux N. V. Terneuzen (75)(75) Hollingworth, R.L. (1951). Report of The Dow Chemical Company, 13.8. 1951. [IUCLID 2000]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,NCCNCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.108J,J-GLOBAL,NCCNCCN,Train,1,2702,training
-"JP_CHRIP:
-N-(2-Aminoethyl)-2-aminoethanol
-
-NZ_CCID:
-2-(2-Aminoethylamino) ethanol","JP_CHRIP:
-2-(2-aminoethylamino)ethanol
-Ethanol, 2-[(2-aminoethyl)amino]-
-N-(2-aminoethyl)-2-aminoethanol
-
-NZ_CCID:
-N-aminoethylethanolamine",111-41-1,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0081e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4E713A4E-89DE-41C3-8C21-DDA1A6910DC0","JP_CHRIP:
-In a test by a semi-occlusive application of 0.5 mL of undiluted this substance to the rabbit skin, necrosis occurred in 2/2 animals after a 4-hour application and 1/4 animals after a 1-hour application, and full-thickness skin necrosis was confirmed by pathological examination (SIDS (2008)). And full-thickness skin necrosis was also observed after a 4-hour or 1-hour application in another test by an occlusive application of 0.5 mL of undiluted this substance to the rabbit skin, and it was judged as corrosive (SIDS (2008)), but only minor irritation was noted after a 3-minute application. Therefore, it was classified in Category 1B. Besides, it was classified in C: R34 in EU classification (EC-JRC (ESIS) (Access on Aug. 2012)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,NCCNCCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.188F,J-GLOBAL,NCCNCCO,Train,1,2702,training
-"AU_HCIS:
-Ethanol, 2,2'-iminobis-
-
-JP_CHRIP:
-2,2'-Iminodiethanol
-
-NZ_CCID:
-Diethanolamine","AU_HCIS:
-2,2'-iminodiethanol
-Diethanolamine
-
-JP_CHRIP:
-2,2'-Dihydroxydiethylamine
-DEA
-Diethanolamine
-
-NZ_CCID:
-2-(2-Hydroxyethylamino)ethanol, Di(2-hydroxyethyl)amine, Diolamine, Iminodiethanol, N,N-Bis(2-hydroxyethyl)amine, N,N-Diethanolamine",111-42-2,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1882
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-2013e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F56F0894-174F-425A-B120-0CC49239427C","JP_CHRIP:
-In a test in which the test substance was applied to the rabbit skin without dilution, the skin irritation index (PII) was 2.6 (/8), corresponding to slight irritation. However, because it was assessed to be moderate irritation (SIDS (2008)), the pH of a 0.1 N aqueous solution of this substance was 11 (Merck 14th, 2006), and the EU classified it in Xi; R38, it was classified in Category 2.
-
-NZ_CCID:
-Skin Irritation
-R-PHRASE: R 38 Irritating to skin. [IUCLID 2000]
-Eye Irritation
-R-PHRASE: R 41 Risk of serious damage to eyes. [IUCLID 2000]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,OCCNCCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J808G,J-GLOBAL,OCCNCCO,Train,1,2702,training
-"NZ_CCID:
-Isobutylisopropyldimethoxysilane",,111439-76-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AE0D8950-6C41-4D2B-AB06-88F8E36BD6CF,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(C)C[Si](C(C)C)(OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/86305,PubChem,CO[Si](CC(C)C)(OC)C(C)C,Train,1,2702,training
-"JP_CHRIP:
-Bis(2-chloroethyl) ether","JP_CHRIP:
-1,1'-Oxybis(2-chloro)ethane
-2,2'-dichlorodiethyl ether
-2,2'-Dichloroethyl ether
-BCEE
-Bis(2-chloroethyl)ether
-Bis(chloroethyl)ether
-Dichloroethyl ether
-Diethylene glycol dichloride
-sym-Dichloroethyl ether",111-44-4,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2115e.html,"JP_CHRIP:
-There are multiple descriptions that skin irritation was seen after an application of this substance in skin irritation tests with rabbits (ATSDR (1989), BUA 21 (1987)), therefore, it was classified in Category 2.",,JP_CHRIP,1,ClCCOCCCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.455D,J-GLOBAL,ClCCOCCCl,Train,1,2702,training
-"JP_CHRIP:
-2,2'-thiodiethanol; thiodiglycol","JP_CHRIP:
-2,2'-Thiodiethanol
-Di(2-hydroxyethyl) sulfide
-Diethanolsulfide
-Thiodiethylene glycol
-Thiodiglycol",111-48-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0039e.html,"JP_CHRIP:
-Skin irritation tests using rabbits (complied with OECD guideline 404) concluded that the substance was not an irritant, based on the observation of slight erythema (score 1) in 1 of 3 treated rabbits (SIDS (2004)). From these results, the substance was classified into ""Not classified"" (also ""Not classified"" in the United Nations classification).",Provided,JP_CHRIP,1,OCCSCCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.988G,J-GLOBAL,OCCSCCO,Train,1,2702,training
-"JP_CHRIP:
-Hexahydro-1H-azepin
-
-NZ_CCID:
-Hexamethyleneimine","JP_CHRIP:
-Hexamethylenimine",111-49-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0103e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/ED5CDB33-85DF-4F51-A46F-8D601369484F","JP_CHRIP:
-Since the undiluted substance was dermally corrosive, producing an intact scab after 14 days by occluded application to the skin for 24-hour in an acute dermal toxicity test in rabbits (HSDB (2003)), the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,C1CCCNCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J22.113I,J-GLOBAL,C1CCCNCC1,Train,1,2702,training
-"NZ_CCID:
-Adipoyl dichloride",,111-50-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7BEAA83C-BC76-4D17-9707-03DC183E614A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(CCC(=O)Cl)CC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/61034,PubChem,O=C(Cl)CCCCC(=O)Cl,Train,1,2702,training
-"EU_REACH:
-1,4-diethyl 2-acetylbutanedioate",,1115-30-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18399/7/4/2/?documentUUID=bd427c12-7b4b-4bf3-89ea-99a4ec6eea8d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CC(C(=O)C)C(=O)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/66197,PubChem,CCOC(=O)CC(C(C)=O)C(=O)OCC,Train,1,2702,training
-"NZ_CCID:
-Metformin hydrochloride
-
-US_HSDB:
-METFORMIN",,1115-70-4,Cat 2,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B616A9C3-4786-4175-874C-D4B7AD3AB68C
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/7080","NZ_CCID:
-Skin Irritation
-REMARK: Confidential information supplied by registrant.
-Eye Irritation
-REMARK: Confidential information supplied by registrant.",,"NZ_CCID, US_HSDB",2,CN(C)C(=N)N=C(N)N,https://pubchem.ncbi.nlm.nih.gov/compound/4091,PubChem,CN(C)C(=N)N=C(N)N,Train,1,2702,training
-"NZ_CCID:
-Triisobutylamine","NZ_CCID:
-1-Propanamine, 2-methyl-N,N-bis(2-methylpropyl)-",1116-40-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A4406924-5585-431C-ABD5-5B23859590CD,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CC(C)CN(CC(C)C)CC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/14222,PubChem,CC(C)CN(CC(C)C)CC(C)C,Train,1,2702,training
-"JP_CHRIP:
-n-Octane","JP_CHRIP:
-n-Octane",111-65-9,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2025e.html,"JP_CHRIP:
-There is a report that in a test with volunteers, in which this substance was applied on the forearm for 1 hour and on the thigh for 5 hours, hyperemia, inflammation and pigmentation occurred with a burning and itching sensation at the site of application (PATTY (6th, 2012)). It is also described that after the 5-hour application, blister formation was observed but this disappeared (HSDB (Access on July 2014)). Based on the above, this substance was classified in Category 2.",,JP_CHRIP,1,CCCCCCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J10.709C,J-GLOBAL,CCCCCCCC,Train,1,2702,training
-"JP_CHRIP:
-Oct-1-ene; 1-Octene
-
-NZ_CCID:
-1-Octene","JP_CHRIP:
-1-Caprylene
-1-Octene
-1-Octylene
-
-NZ_CCID:
-1-N-Octene, Caprylene, N-1-Octene",111-66-0,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0039e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0B9E4ED5-3CD6-4164-941A-8677F205FBE6","JP_CHRIP:
-In the rabbit test (OECD TG404, GLP-compliant), exposure of the substance caused well-defined erythema and slight to severe edema, but these signs recovered by day 7. However, desquamation and crust formation were noted, and the Draize PII (primary irritation index) was 3.42 on a scale of 8 (SIDS (2000)), thus the substance was classified as Category 2.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: For a 24 hr exposure the Primary Irritation Score (PIS) in rabbits is 3.42. (The 24-72 hour EU
-Skin Irritation scores for erythmia and oedema, respectively, in rabbits are: 1.9 and 1.1.)
-REFERENCE SOURCE: CP Chem MSDS
-R-PHRASE: R 38 Irritating to skin. [http://physchem.ox.ac.uk/MSDS/OC/1-octene.html]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: The mean 24-hour draize
-Eye Irritation score in rabbits is 0.3
-REFERENCE SOURCE: CP Chem MSDS
-R-PHRASE: R 36 Irritating to eyes. [http://physchem.ox.ac.uk/MSDS/OC/1-octene.html]",Provided,"JP_CHRIP, NZ_CCID",2,CCCCCCC=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.113F,J-GLOBAL,C=CCCCCCC,Train,1,2702,training
-"AU_HCIS:
-1-Octanamine, N,N-dioctyl-
-
-NZ_CCID:
-Trioctylamine",,1116-76-3,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5198
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/87857B16-1039-4117-BD85-533E84851580","NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,"AU_HCIS, NZ_CCID",2,CCCCCCCCN(CCCCCCCC)CCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/14227,PubChem,CCCCCCCCN(CCCCCCCC)CCCCCCCC,Train,1,2702,training
-"EU_REACH:
-heptylamine
-
-NZ_CCID:
-1-Heptanamine",,111-68-2,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21376/7/4/2/?documentUUID=da3261b7-0bd2-491d-a298-98121729689b
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3FDCD552-1EEB-4D8C-B7AE-6CC5FBF7A118","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",Provided,"EU_REACH, NZ_CCID",2,CCCCCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/8127,PubChem,CCCCCCCN,Train,1,2702,training
-"JP_CHRIP:
-1-Heptanol","JP_CHRIP:
-1-Heptanol
-1-Hydroxyheptane
-Heptane-1-ol
-n-Heptanol
-n-Heptyl alcohol",111-70-6,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0155e.html,"JP_CHRIP:
-The substance was classified as Category 2 based on the documented case of ""moderately irritating"" resulted from the rabbit test in which undiluted substance was applied for 24 hours (PATTY, 5th (2001)). As relevant notes, it was reported that the occlusive application of 1% of the substance in petrolatum for 48 hours caused no irritation to human skin (PATTY, 5th (2001), original literature: D. L. J. Opdyke, Food Cosmet. Toxicol.13, p 697-698 (1975)).",,JP_CHRIP,1,CCCCCCCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.457K,J-GLOBAL,CCCCCCCO,Train,1,2702,training
-"JP_CHRIP:
-Heptanal",,111-71-7,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0021e.html,"JP_CHRIP:
-On the basis of a Primary Irritation Index (PII) of 5.0 in a test (OECD TG 404, GLP compliance), in which moderate erythema and slight oedema were observed until 7 days after the application of 0.5 mL of an undiluted test substance solution to rabbit skins for 4 hours (ECETOC TR 66 (1995)), it was classified in Category 2.",Provided,JP_CHRIP,1,CCCCCCC=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.520D,J-GLOBAL,CCCCCCC=O,Train,1,2702,training
-"JP_CHRIP:
-Ethylene glycol mono-n-butyl ether, (Butyl cellosolve)","JP_CHRIP:
-2-n-butoxyethanol
-Butyl cellosolve
-Butyl oxitol
-EGBE
-Ethanol, 2-butoxy-
-Ethylene glycol mono-n-butyl ether
-Ethylene glycol mono-n-butyl ether; Butylcellosolve
-Ethylene glycol monobutyl ether
-Monobutyl glycol ether",111-76-2,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2021e.html,"JP_CHRIP:
-There were multiple reports of skin irritation test with rabbits. It was reported that, in 2 tests equivalent to OECD TG 404, it was irritating (SIDS (2006), ECETOC TR95 (2005), NICNAS (1996)), and that although severe and persistent erythema and severe edema were observed as the findings, they disappeared after 7 days (SIDS (2006)). It was reported that in other skin irritation tests by 4-hour application, it was ""mildly irritating"" or ""irritating"" (SIDS (2006), ECETOC TR95 (2005), EU-RAR (2006)). In addition, after applying to rabbits under semi-occlusive conditions for 24 hours, mild to moderate erythema (5/6 animals) and mild edema (4/6 animals) were observed immediately after application, and mild to moderate erythema (4/6 animals) and mild edema (3/6 animals) were observed 48 hours after application (EU-RAR (2006)). The primary irritation score was 1.5 in this test. Additionally, there is a result that it was irritating in a skin irritation test with guinea pigs (SIDS (2006), EU-RAR (2006)). Based on the above results, it was classified in Category 2. Besides, this substance was classified in ""R38"" by EU DSD classification, and in ""H315 Skin Irrit. 2"" in EU CLP classification.",Provided,JP_CHRIP,1,CCCCOCCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.458I,J-GLOBAL,CCCCOCCO,Train,1,2702,training
-"JP_CHRIP:
-2-(2-Methoxyethoxy)ethanol (synonym: Diethylene glycol monomethyl ether)","JP_CHRIP:
-DEGME",111-77-3,NC,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2009.html,"JP_CHRIP:
-【分類根拠】
-（１）、（２）より、区分に該当しない。
-
-【根拠データ】
-（１）ウサギ（n=6）を用いた皮膚刺激性試験（OECD TG 404 相当、閉塞、4時間適用、72時間観察）において、皮膚刺激性はみられなかった（紅斑・痂皮スコア：0/0/0/0/0/0、浮腫スコア：0/0/0/0/0/0）との報告がある（EU RAR (2000)、AICIS IMAP (2013)、REACH登録情報 (Accessed July 2021)、Government of Canada, Hazadous Substance Assessement (2020)）。
-（２）ウサギ、モルモットを用いたDraize試験において、軽度の皮膚刺激性を示したとの報告がある（Government of Canada, Hazadous Substance Assessement (2020)）。",Provided,JP_CHRIP,1,COCCOCCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.114D,J-GLOBAL,COCCOCCO,Train,1,2702,training
-"EU_REACH:
-methyl undec-10-enoate",,111-81-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10072/7/4/2/?documentUUID=37d10816-0ce5-4a40-bd98-6a2464773183,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)CCCCCCCCC=C,https://pubchem.ncbi.nlm.nih.gov/compound/8138,PubChem,C=CCCCCCCCCC(=O)OC,Train,1,2702,training
-"JP_CHRIP:
-n-Nonane","JP_CHRIP:
-2,2,5-Trimethylhexane
-n-Nonane",111-84-2,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2075e.html,"JP_CHRIP:
-There is a report that redness was observed, and moderate irritation was observed after 24 hours in a test in which 0.23 mL of this substance was applied to rabbits for 1 hour (Draize test) (SIDS (2013)). Based on the above result, this substance was classified in Category 2.",,JP_CHRIP,1,CCCCCCCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.957G,J-GLOBAL,CCCCCCCCC,Train,1,2702,training
-"EU_CLP:
-4-(4-nitrophenylazo)-2,6-di-sec-butyl-phenol",,111850-24-9,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCC(C)C1=CC(=CC(=C1O)C(C)CC)N=NC2=CC=C(C=C2)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/136029257,PubChem,CCC(C)c1cc(N=Nc2ccc([N+](=O)[O-])cc2)cc(C(C)CC)c1O,Test,1,2702,training
-"EU_REACH:
-octan-1-amine
-
-JP_CHRIP:
-1-Octanamine
-
-NZ_CCID:
-Octylamine","NZ_CCID:
-n-octylamine",111-86-4,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16566/7/4/2/?documentUUID=987529f3-c3c1-4ff0-bb68-5322adbe51d1
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0007e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/49BD61B3-14EF-4370-8306-3D0EC143C390","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-It was classified in Category 1 because it is reported that in an acute toxicity test by dermal administration to rabbits, necrosis was observed at the sites of application of this substance in the 200 mg/kg dose group during a 7-day observation period (RTECS (1997): the original article, United States Environmental Protection Agency, Office of Pesticides and Toxic Substances: 8EHQ-1085-0569), and it is also described that 1-octanamine is a severe skin irritant (PATTY (5th, 2001)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,CCCCCCCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.115B,J-GLOBAL,CCCCCCCCN,Train,1,2702,training
-"NZ_CCID:
-Allyl acetoacetate",,1118-84-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/077206FC-5A45-4C45-8ABF-FA2E6035EBA9,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CC(=O)CC(=O)OCC=C,https://pubchem.ncbi.nlm.nih.gov/compound/70701,PubChem,C=CCOC(=O)CC(C)=O,Train,1,2702,training
-"NZ_CCID:
-Octanamide, N,N-dimethyl-","NZ_CCID:
-N,N-Dimethyloctanamide",1118-92-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6E8176F7-91D3-48E3-9A49-83848B181619,"NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Severely irritating
-REFERENCE SOURCE: (Harris, 1990); (Kreuzmarm, 1990b). (Test Plan for N,N-dimethyloctanamide and N,N-dimethyldecanamide 12-16-02) [HPV]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Highly irritating
-REFERENCE SOURCE: (Kreuzmann, 1990~) Test Plan for N,N-dimethyloctanamide and N,N-dimethyldecanamide 12-16-02 [HPV]",,NZ_CCID,1,CCCCCCCC(=O)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/14240,PubChem,CCCCCCCC(=O)N(C)C,Train,1,2702,training
-"JP_CHRIP:
-Bis(2-chloroethoxy) methane","JP_CHRIP:
-Bis(2-chloroethoxy)methane
-Ethane, 1,1'-[methylenebis(oxy)]bis[2-chloro-",111-91-1,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0064e.html,"JP_CHRIP:
-Though there is no specific information, from the information that this substance is irritating to skin, it was classified in Category 2 (Result of the initial environmental risk assessment of chemicals, Vol. 6, Ministry of the Environment in Japan: Tentative hazard assessment sheet (2008); HSDB (Access on July 2015)).",,JP_CHRIP,1,ClCCOCOCCCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J47.053H,J-GLOBAL,ClCCOCOCCCl,Train,1,2702,training
-"JP_CHRIP:
-di-n-butylamine;
-
-KR_NCIS:
-Di-n-butylamine","JP_CHRIP:
-di-n-butylamine
-N-Butyl-1-butanamine
-n-Dibutylamine
-
-KR_NCIS:
-Dibutylamine; N-Butyl-1-butanamine; N-Butylbutan-1-amine",111-92-2,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0173e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP:
-The classification was based on the description that the substance is found to be corrosive in Draize tests using rabbits (IUCLID (2000)).",,"JP_CHRIP, KR_NCIS",2,CCCCNCCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.886J,J-GLOBAL,CCCCNCCCC,Train,1,2702,training
-"EU_REACH:
-1,5-dimethyl pentanedioate",,1119-40-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5377/7/4/2/?documentUUID=e021234e-30db-497e-80e1-0dcf4c27823b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)CCCC(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/14242,PubChem,COC(=O)CCCC(=O)OC,Train,1,2702,training
-"NZ_CCID:
-5-Chlorovaleric acid",,1119-46-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/42FACE71-DC2A-4576-AC67-F1EB3D13E280,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(CCCl)CC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/14244,PubChem,O=C(O)CCCCCl,Train,1,2702,training
-"NZ_CCID:
-5-Bromo-1-pentene",,1119-51-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/16FBAF55-1103-4761-8A66-D1A08431AB14,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C=CCCCBr,https://pubchem.ncbi.nlm.nih.gov/compound/70704,PubChem,C=CCCCBr,Train,1,2702,training
-"ChemSkin:
-3,3′-Dithiodipropionic acid",,1119-62-6,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,C(CSSCCC(=O)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/95116,PubChem,O=C(O)CCSSCCC(=O)O,Test,1,2702,training
-"JP_CHRIP:
-Thiacloprid",,111988-49-9,NC,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2010.html,"JP_CHRIP:
-【分類根拠】
-（１）～（３）より、区分に該当しない。
-
-【根拠データ】
-（１）ウサギを用いた皮膚刺激性試験において、皮膚刺激性はみられなかったとの報告がある（食安委 農薬評価書 (2019)）。
-（２）ウサギ（n=3）を用いた皮膚刺激性試験（OECD TG 404）において、非常に軽度の紅斑が全例でみられたが、適用後72時間以内にすべて回復した（紅斑・痂皮スコア：1/1/0、浮腫スコア：0/0/0）との報告がある（ECHA RAC Opinion (2015)、CLH Report (2013)）。
-（３）本物質はウサギに対して皮膚刺激物ではない（JMPR Report (2006)）。",Provided,JP_CHRIP,1,Clc1ccc(CN2CCSC2=NC#N)cn1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.459.101J,J-GLOBAL,N#CN=C1SCCN1Cc1ccc(Cl)nc1,Train,1,2702,training
-"EU_REACH:
-6-cyclopentylidenehexanal",,111998-18-6,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33917/7/4/2/?documentUUID=01d6e289-e897-4895-b718-1c30673c161a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CCC(=CCCCCC=O)C1,https://pubchem.ncbi.nlm.nih.gov/compound/14022233,PubChem,O=CCCCCC=C1CCCC1,Train,1,2702,training
-"NZ_CCID:
-Dioctylamine",,1120-48-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/107CAA4D-F41F-4FB7-B069-E122EE5D080C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCCCCCCCNCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/3094,PubChem,CCCCCCCCNCCCCCCCC,Train,1,2702,training
-"NZ_CCID:
-Trichlorooctadecylsilane","NZ_CCID:
-octadecyltrichlorosilane",112-04-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CB495C1C-ED21-40AF-BE7C-03ADFFD919A2,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCCCCCCCCCCCCCC[Si](Cl)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/8157,PubChem,CCCCCCCCCCCCCCCCCC[Si](Cl)(Cl)Cl,Train,1,2702,training
-"EU_REACH:
-(R)-5-(2-Aminopropyl)-2-methoxybenzenesulfonamide",,112101-81-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30158/7/4/2/?documentUUID=6427986c-cc44-4f80-96e2-adb0c20a46d7,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@H](CC1=CC(=C(C=C1)OC)S(=O)(=O)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/10060387,PubChem,COc1ccc(C[C@@H](C)N)cc1S(N)(=O)=O,Train,1,2702,training
-"NZ_CCID:
-2-Mercaptophenol",,1121-24-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8035A483-98C5-4789-B810-CFCD30FD1C29,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)O)S,https://pubchem.ncbi.nlm.nih.gov/compound/70718,PubChem,Oc1ccccc1S,Train,1,2702,training
-"NZ_CCID:
-Decanoyl chloride",,112-13-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1D2D0EAE-9D70-48EC-A7CF-137C20E661EF,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCCCCCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/66982,PubChem,CCCCCCCCCC(=O)Cl,Train,1,2702,training
-"NZ_CCID:
-Lauroyl chloride",,112-16-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/219A2202-4420-421E-B98B-AB2B24BD2676,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCCCCCCCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/8166,PubChem,CCCCCCCCCCCC(=O)Cl,Train,1,2702,training
-"AU_HCIS:
-1-Dodecanamine, N,N-dimethyl-
-
-EU_REACH:
-dodecyldimethylamine
-
-JP_CHRIP:
-N,N-Dimethyldodecan-1-ylamine
-
-NZ_CCID:
-Dimethyldodecylamine","JP_CHRIP:
-dodecyldimethylamine
-lauryldimethylamine
-N,N-dimethyldodecylamine
-
-NZ_CCID:
-1-Dodecanamine, N,N-dimethyl-, Genamin LA 302 D, N,N-dimethyl-1-dodecanamine, N,N-dimethyldodecylamine, N,N-dimethyllaurylamine, armeen dm-12d, dodecyldimethylamine, lauryldimethylamine, monolauryl dimethylamine, n-dodecyldimethylamine, n-lauryldimethylamine",112-18-5,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5000
-EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14856/7/4/2/?documentUUID=dbc54309-bb73-4af9-810d-214ad44bea6c
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-meti-2005e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7FB884CC-31F2-4F06-9F08-0082B34C0E72","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-[Rationale for the Classification]
-Based on (1)-(3), it was classified in Category 1 according to the GHS Classification Guidance for the Japanese Government. Besides, although Category 1A is suggested from the information in (2), sub-categorization was not conducted since the information in (3) was also obtained.
-
-[Evidence Data]
-(1) It is reported that this substance is severely irritating to human skins (Environmental Risk Assessment for Chemical Substances vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)).
-(2) There is a report that in a skin irritation test (OECD TG 404) with rabbits, both of the two products with different purities (the content of this substance: 95%, 70%) were corrosive after application for 4 hours or 3 minutes (SIDS (2004)).
-(3) There are reports that in the skin irritation test (OECD TG 404) with rabbits, in all of two tests showing corrosivity and one test showing irritation, in which a 3-minute or 4-hour application was followed by a 1-hour observation, the erythema scores were lower than 4, and the criteria of Category 1A were not met (NICNAS IMAP (Accessed Oct. 2018)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Corrosive
-REFERENCE SOURCE: Hoechst AG Frankfurt 80 Hoechst AG Frankfurt/Main [IUCLID 2000]
-REMARK: EC Classification: Corrosive (causes burns)
-
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Moderately irritating
-REFERENCE SOURCE: Hoechst AG Frankfurt 80 Hoechst AG Frankfurt/Main [IUCLID 2000]
-REMARK: EC Classification: Irritating.",Provided,"AU_HCIS, EU_REACH, JP_CHRIP, NZ_CCID",4,CCCCCCCCCCCCN(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J27.950A,J-GLOBAL,CCCCCCCCCCCCN(C)C,Train,1,2702,training
-"NZ_CCID:
-Nonylamine","NZ_CCID:
-n-nonylamine",112-20-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5347AC53-41F6-4BD4-A6CE-2D570D252F4E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCCCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/16215,PubChem,CCCCCCCCCN,Train,1,2702,training
-"AU_HCIS:
-3,6-diazaoctanethylenediamin
-
-JP_CHRIP:
-3,6-diazaoctanethylenediamin; triethylenetetramine
-
-NZ_CCID:
-Triethylenetetramine","AU_HCIS:
-triethylenetetramine
-1,2-Ethanediamine, N,N'-bis(2-aminoethyl)-
-trientine
-
-JP_CHRIP:
-3,6-Diazaoctane-1,8-diamine
-trientine
-Triethylenetetramine
-
-NZ_CCID:
-1,4,7,10-Tetraazadecane, 1,8-Diamino-3,6-diazaoctane, 3,6-Diazaoctane-1,8-diamine, Araldite hardener HY 951, TETA, Tecza, Trien, Trientine",112-24-3,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1203
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0042e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/914A6290-E1D7-4845-A4B9-FE061289559A","JP_CHRIP:
-In rabbit skin tests, the substance caused not only erythema and edema, but also necrosis in several tests (SIDS (1998)). Thus, the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT:
-Skin Irritation Grade 6. 6 = more necrosis from undiluted, less than edema from 10%.
-REFERENCE SOURCE: [Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963. 2046]**PEER REVIEWED** [HSDB]
-R PHRASE: R 34 [N-CLASS]
-Eye Irritation
-R-PHRASE: R 34 [N-CLASS]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,NCCNCCNCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.120I,J-GLOBAL,NCCNCCNCCN,Train,1,2702,training
-"JP_CHRIP:
-2-Hexyloxyethanol","JP_CHRIP:
-2-(Hexyloxy)ethanol
-EGHE
-Glycol monohexyl ether
-n-Hexyglycol",112-25-4,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2108e.html,"JP_CHRIP:
-In a test (Directive 84/449/EEC, B4) where the substance (stock solution) was applied to the skin of 6 rabbits for 4-hour, skin reactions developed within 1-hour after application (average erythema and edema Draize scores were 1.3 and 1.7, respectively). The effects were resolved between 2 to 7 days. 3 rabbits showed necrosis at the application site between Days 1 and 7, desquamation was found in 4 animals on Day 7 (SIDS (access on Aug. 2008)). The results indicated that the erythema, edema and necrosis which developed following application showed recovery or a trend of recovery within 7 days. Based on the data, the substance was classified into Category 2. In another rabbit test, there is a result of ""not irritating"" (SIDS (access on Aug. 2008)). In EU classification, the substance is classified into R34 (EU-Annex I (access on Aug. 2008)).",,JP_CHRIP,1,CCCCCCOCCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J92.968I,J-GLOBAL,CCCCCCOCCO,Train,1,2702,training
-"NZ_CCID:
-Methyl 4-pyridyl ketone","NZ_CCID:
-4-acetylpyridine",1122-54-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7B63218E-8A2E-4C55-8846-0109420A7CD3,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CC(=O)C1=CC=NC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/14282,PubChem,CC(=O)c1ccncc1,Train,1,2702,training
-"NZ_CCID:
-4-(Dimethylamino) pyridine","NZ_CCID:
-4-dimethylaminopyridine",1122-58-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F3F8FF71-0DFB-497C-857F-0785FC71C299,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CN(C)C1=CC=NC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/14284,PubChem,CN(C)c1ccncc1,Train,1,2702,training
-"NZ_CCID:
-Methyl 2-pyridyl ketone",,1122-62-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4A724EF9-D041-4A75-8544-B23EC1BD7FE0,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CC(=O)C1=CC=CC=N1,https://pubchem.ncbi.nlm.nih.gov/compound/14286,PubChem,CC(=O)c1ccccn1,Train,1,2702,training
-"ChemSkin:
-Triethylene glycol",,112-27-6,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,C(COCCOCCO)O,https://pubchem.ncbi.nlm.nih.gov/compound/8172,PubChem,OCCOCCOCCO,Test,1,2702,training
-"NZ_CCID:
-4-Bromobenzaldehyde",,1122-91-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BC823DFF-A330-4449-B077-9E3F77F321BC,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1C=O)Br,https://pubchem.ncbi.nlm.nih.gov/compound/70741,PubChem,O=Cc1ccc(Br)cc1,Train,1,2702,training
-"US_HSDB:
-DECALDEHYDE",,112-31-2,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/288,,,US_HSDB,1,CCCCCCCCCC=O,https://pubchem.ncbi.nlm.nih.gov/compound/8175,PubChem,CCCCCCCCCC=O,Train,1,2702,training
-"ChemSkin:
-Methyl palmitate ####",,112-39-0,Cat 2,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,CCCCCCCCCCCCCCCC(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/8181,PubChem,CCCCCCCCCCCCCCCC(=O)OC,Test,1,2702,training
-"JP_CHRIP:
-Dodec-1-ene; 1-Dodecene
-
-NZ_CCID:
-1-Dodecene","JP_CHRIP:
-1-Dodecene
-alpha-Dodecene
-alpha-Dodecylene
-Dodecene
-Dodecylene
-N-Dodec-1-ene",112-41-4,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0040e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CBF0E886-CBB2-420F-8E01-290CEECA8428","JP_CHRIP:
-In the Draize test (OECD TG 404, GLP-compliant) using rabbit, no corrosive effects were noted, and moderate to severe erythema and slight to severe edema were observed. These symptoms were cleared by day 14, and the primary irritation index was 4.67 (SIDS (2000)). Based on the document, the substance was classified as Category 2.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",Provided,"JP_CHRIP, NZ_CCID",2,CCCCCCCCCCC=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J43.534A,J-GLOBAL,C=CCCCCCCCCCC,Train,1,2702,training
-"NZ_CCID:
-1-Chlorododecane",,112-52-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/01FF6CDD-5B65-4929-BA7D-E397B0989EB2,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CCCCCCCCCCCCCl,https://pubchem.ncbi.nlm.nih.gov/compound/8192,PubChem,CCCCCCCCCCCCCl,Train,1,2702,training
-"NZ_CCID:
-Lauraldehyde","NZ_CCID:
-dodecyl aldehyde",112-54-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8F1A9464-7CC4-442F-9B72-7938B111C150,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CCCCCCCCCCCC=O,https://pubchem.ncbi.nlm.nih.gov/compound/8194,PubChem,CCCCCCCCCCCC=O,Train,1,2702,training
-"AU_HCIS:
-3,6,9-triazaundecamethylenediamine
-
-JP_CHRIP:
-3,6,9-triazaundecamethylenediamine; tetraethylenepentamine
-
-NZ_CCID:
-Tetraethylenepentamine","AU_HCIS:
-tetraethylenepentamine
-1,2-Ethanediamine, N-(2-aminoethyl)-N'-[2-[(2-aminoethyl)amino]ethyl]-
-
-JP_CHRIP:
-1,11-Diamino-3,6,9-triazaundecane
-3,6,9-Triazaundecane-1,11-diamine
-TEPA
-Tetraethylenepentamine
-Tetrene",112-57-2,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4545
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0044e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8F36AABA-11B0-4CDB-A52A-5BA52444ED0D","JP_CHRIP:
-In several rabbit tests (Draize tests, etc.), exposure to the undiluted substance for 4 hours resulted in necrosis in half or more animals and the substance was concluded to be corrosive (SIDS (accessed in June 2008)). In addition, its EU Risk Phrase is ""R34: corrosive"" and its pH is >= 11.5. From these, the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [IUCLID 2000]
-
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Severe burns.
-REFERENCE SOURCE: [Lefaux, R. Practical Toxicology of Plastics. Cleveland: CRC Press Inc., 1968. 166]**PEER REVIEWED**[HSDB]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,NCCNCCNCCNCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.129B,J-GLOBAL,NCCNCCNCCNCCN,Train,1,2702,training
-"ChemSkin:
-Methyl stearate #",,112-61-8,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,CCCCCCCCCCCCCCCCCC(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/8201,PubChem,CCCCCCCCCCCCCCCCCC(=O)OC,Test,1,2702,training
-"NZ_CCID:
-Tetradecanoyl chloride",,112-64-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9FCDB945-04F4-47A2-9B24-32ABD85A6C15,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCCCCCCCCCCCCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/66986,PubChem,CCCCCCCCCCCCCC(=O)Cl,Train,1,2702,training
-"NZ_CCID:
-Palmitoyl chloride",,112-67-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CB410A6C-0C28-4EF3-9D2C-8C11B6F17EED,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCCCCCCCCCCCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/8206,PubChem,CCCCCCCCCCCCCCCC(=O)Cl,Train,1,2702,training
-"NZ_CCID:
-1-Tridecanol",,112-70-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BC661381-5CD0-4D8B-9BB6-8E3D1E0CA568,"NZ_CCID:
-Skin Irritation
-SPECIES: Human
-RESULT: Moderate
-REFERENCE SOURCE: [U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Manual Two. Washington, DC: U.S. Government Printing Office, Oct., 1978., p. ]**PEER REVIEWED**",,NZ_CCID,1,CCCCCCCCCCCCCO,https://pubchem.ncbi.nlm.nih.gov/compound/8207,PubChem,CCCCCCCCCCCCCO,Train,1,2702,training
-"EU_REACH:
-1-[2-(2-butoxyethoxy)ethoxy]butane",,112-73-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5839/7/4/2/?documentUUID=a75bca5d-9bd3-4b29-b27a-e3e218dce05d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOCCOCCOCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/8210,PubChem,CCCCOCCOCCOCCCC,Train,1,2702,training
-"NZ_CCID:
-Oleoyl chloride",,112-77-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/11029E3A-A995-4626-9CAA-E84C7EEE9196,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCCCC/C=C\CCCCCCCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/5364783,PubChem,CCCCCCCC/C=C\CCCCCCCC(=O)Cl,Train,1,2702,training
-"NZ_CCID:
-Oleic acid",,112-80-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AD4E695B-2CE2-4F04-8737-38512EFDE3AB,"NZ_CCID:
-Skin Irritation
-SPECIES:
-RESULT: Irritating
-REFERENCE: U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office, 1984-5. **PEER REVIEWED** [HSDB]
-Eye Irritation
-SPECIES:
-RESULT: Irritating
-REFERENCE: U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office, 1984-5. **PEER REVIEWED** [HSDB]",,NZ_CCID,1,CCCCCCCC/C=C\CCCCCCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/445639,PubChem,CCCCCCCC/C=C\CCCCCCCC(=O)O,Train,1,2702,training
-"EU_REACH:
-3,3-dimethoxy-8,8,9,9-tetramethyl-2-oxa-7-thia-3,8-disiladecane",,1128026-41-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1923/7/4/2/?documentUUID=c629abdf-5a6e-4694-8773-e687fdcd930f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)[Si](C)(C)SCCC[Si](OC)(OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/89888895,PubChem,CO[Si](CCCS[Si](C)(C)C(C)(C)C)(OC)OC,Test,1,2702,training
-"ChemSkin:
-Erucamide",,112-84-5,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,CCCCCCCC/C=C\CCCCCCCCCCCC(=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/5365371,PubChem,CCCCCCCC/C=C\CCCCCCCCCCCC(N)=O,Test,1,2702,training
-"AU_HCIS:
-(Z)-octadec-9-enylamine
-
-JP_CHRIP:
-(Z)-9-Octadecen-1-amine; oleylamine
-
-NZ_CCID:
-Oleyl amine","AU_HCIS:
-9-Octadecen-1-amine, (Z)-
-
-JP_CHRIP:
-(Z)-9-Octadecene-1-amine
-(Z)-Octadec-9-en-1-ylamine",112-90-3,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4780
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0083e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4D4A053D-3B5F-44F8-A629-523C7F2A07FE","JP_CHRIP:
-It was classified in Category 1 because it is reported that necrosis was noted, and average Draize scores were 4.0 for both erythema and edema in a test by a 4-hour semi-occlusive application of 0.5 mL of the test substance to the rabbit skin (OECD TG 404), which was terminated for humane reasons (EU-RAR (2008)), and in another test with rabbits and almost the same test conditions (OECD TG 404), average Draize scores after 24, 48, and 72 hours for erythema and edema were 4.0, 3.7, and 3.7, and corrosive effects (eschar, scabbing, scarring) were observed at the application sites of all animals (EU-RAR (2008)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",Provided,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CCCCCCCC/C=C\CCCCCCCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J59.382F,J-GLOBAL,CCCCCCCC/C=C\CCCCCCCCN,Train,1,2702,training
-"NZ_CCID:
-Eicosane",,112-95-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/150239E3-D91F-4763-AEA2-9D00E5F617FD,,,NZ_CCID,1,CCCCCCCCCCCCCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/8222,PubChem,CCCCCCCCCCCCCCCCCCCC,Train,1,2702,training
-"JP_CHRIP:
-Guanidine","JP_CHRIP:
-Guanidine monohydrochloride",113-00-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0084e.html,"JP_CHRIP:
-It was classified in Category 1 because it is described that the pH of a 20% aqueous solution of this substance was 13.5 (Ullmanns (E) (6th, 2003)).",,JP_CHRIP,1,NC(=N)N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.462G,J-GLOBAL,N=C(N)N,Train,1,2702,training
-"EU_REACH:
-3-morpholin-4-ylpropane-1-sulfonic acid",,1132-61-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21270/7/4/2/?documentUUID=5edc7b1e-e258-4b3e-8b0d-bc755d6eecc9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1COCCN1CCCS(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/70807,PubChem,O=S(=O)(O)CCCN1CCOCC1,Train,1,2702,training
-"NZ_CCID:
-2,5,7,7-Tetramethyloctanal",,114119-97-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/96AD90A5-091B-4E39-B067-5C788FC8BF0D,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CC(CCC(C)C=O)CC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/19981043,PubChem,CC(C=O)CCC(C)CC(C)(C)C,Train,1,2702,training
-"EU_REACH:
-(2R)-5-cyclohexyl-2-methylpentan-1-ol; (2S)-5-cyclohexyl-2-methylpentan-1-ol",,1141487-54-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12526/7/4/2/?documentUUID=50687e9b-c1de-4dda-80ab-b6f75ef31d4c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CCCC1CCCCC1)CO,https://pubchem.ncbi.nlm.nih.gov/compound/44192644,PubChem,CC(CO)CCCC1CCCCC1,Train,1,2702,training
-"NZ_CCID:
-Anthralin",,1143-38-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E78CE5A6-93D3-4AF2-A57A-4E1CCF201D59,"NZ_CCID:
-Skin Irritation
-REMARK: Confidential information supplied by registrant.
-Eye Irritation
-REMARK: Confidential information supplied by registrant.",,NZ_CCID,1,C1C2=C(C(=CC=C2)O)C(=O)C3=C1C=CC=C3O,https://pubchem.ncbi.nlm.nih.gov/compound/2202,PubChem,O=C1c2c(O)cccc2Cc2cccc(O)c21,Train,1,2702,training
-"EU_REACH:
-4'-(bromomethyl)-[1,1'-biphenyl]-2-carbonitrile",,114772-54-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2706/7/4/2/?documentUUID=073f47ac-933f-43d6-b011-aad39b702593,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=C1)C#N)C2=CC=C(C=C2)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/1501912,PubChem,N#Cc1ccccc1-c1ccc(CBr)cc1,Train,1,2702,training
-"JP_CHRIP:
-Trichloroethylsilane
-
-NZ_CCID:
-Trichloroethylsilane",,115-21-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0091e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5E1AF554-0C60-4EA6-8917-5928949022D5","JP_CHRIP:
-Based on results that attacked region blanches and blisters after application to the skin of rabbits and that the substance is strong irritant (HSDB (2003)), the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,"JP_CHRIP, NZ_CCID",2,CC[Si](Cl)(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J36.827J,J-GLOBAL,CC[Si](Cl)(Cl)Cl,Train,1,2702,training
-"EU_REACH:
-N-(3-{1,1,1,5,5,5-hexamethyl-3-[(trimethylsilyl)oxy]trisiloxan-3-yl}propyl)prop-2-enamide",,115258-10-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1845/7/4/2/?documentUUID=859bfad8-8741-4310-bd3c-3f32866035fa,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](C)(C)O[Si](CCCNC(=O)C=C)(O[Si](C)(C)C)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/16050379,PubChem,C=CC(=O)NCCC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C,Train,1,2702,training
-"JP_CHRIP:
-2,2,2-trichloro-1,1-bis(4-chlorophenyl)ethanol; Dicofol
-
-KR_NCIS:
-dicofol","JP_CHRIP:
-1,1,-bis(4-chlorophenyl)-2,2,2-trichloroethanol (synonym:dicofol)
-1,1,-bis(p-chlorophenyl)-2,2,2-trichloroethanol (synonym:dicofol)
-4,4'-Dichloro-alpha-(trichloromethyl)benzhydrol
-Benzenemethanol, 4-chloro-alpha-(4-chlorophenyl)-alpha-(trichloromethyl)-
-Dicofol
-Kelthane
-
-KR_NCIS:
-4-Chloro-α-(4-chlorophenyl)-α-(trichloromethyl)benzenemethanol; Acarin; Kelthane",115-32-2,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2061e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP:
-[Rationale for the Classification]
-It was classified in Category 2 from (1) - (3). Because rationale data for the previous classification could not be confirmed, based on newly obtained data in (1) - (3), the classification result was changed.
-
-[Evidence Data]
-(1) In a skin irritation test with rabbits, very slight to well-defined erythema was observed in 2/6 animals at 1 hour after removal of patches. Well-defined to
-moderate to severe erythema was found after 24, 48, and 72 hours and disappeared after 7 days. Very slight to severe edema was present in all animals at 1 hour after removal of patches and persisted through 72 hours but disappeared on day 7. The primary irritation index (PII) was 4.8, and it was considered as a slight to moderate irritant (JMPR Addendum (2011)).
-(2) It was a moderate irritant in a skin irritation test with rabbits according to EPA OPP 81-5 (EPA Pesticides RED (1998)).
-(3) In humans, short-time exposure irritates the eye and skin and causes erythema. Long-term or repeated contact with the skin may cause dermatitis (Environmental Risk Assessment for Chemical Substances vol. 4, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2005)).
-
-[Reference Data, etc.]
-(4) In skin irritation tests with rabbits using emulsion (active ingredient 51%) and wettable powder (active ingredient 35%) of this substance, it was judged as a moderate to severe irritant (Agricultural Chemicals Times supplement ""Agricultural chemicals technology information"" No. 12 (Japan Crop Protection Association, 1992)).",,"JP_CHRIP, KR_NCIS",2,OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)C(Cl)(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.467H,J-GLOBAL,OC(c1ccc(Cl)cc1)(c1ccc(Cl)cc1)C(Cl)(Cl)Cl,Train,1,2702,training
-"EU_REACH:
-1-benzyl-N-phenylpiperidin-4-amine",,1155-56-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23031/7/4/2/?documentUUID=45d50916-b094-4316-8c2b-d926cce09407,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CN(CCC1NC2=CC=CC=C2)CC3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/70865,PubChem,c1ccc(CN2CCC(Nc3ccccc3)CC2)cc1,Train,1,2702,training
-"NZ_CCID:
-2-Amino-2-methyl-1,3-propanediol",,115-69-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5BF70320-7BF7-4D1C-A558-CD1A0FA96C0B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(CO)(CO)N,https://pubchem.ncbi.nlm.nih.gov/compound/1531,PubChem,CC(N)(CO)CO,Train,1,2702,training
-"EU_REACH:
-triphenyl phosphate
-
-JP_CHRIP:
-Triphenyl Phosphate","JP_CHRIP:
-Phosphoric acid, triphenyl ester
-TPP
-Triphenylphosphate",115-86-6,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15972/7/4/2/?documentUUID=abff226e-be6f-4b87-ab1f-c427d9b5e967
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-1000e.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-From description that irritation was not admitted in the test applied to the skin of the rat for 4 hours on DFGOT (2 vol. 1991) and ACGIH (7th, 2001), it was carried out the outside of Category.",Provided,"EU_REACH, JP_CHRIP",2,O=P(Oc1ccccc1)(Oc1ccccc1)Oc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.469D,J-GLOBAL,O=P(Oc1ccccc1)(Oc1ccccc1)Oc1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-Tris(2-chloroethyl) phosphate","JP_CHRIP:
-Ethanol, 2-chloro-, phosphate (3:1)
-TCEP
-Tri(beta-chloroethyl) phosphate
-Tris(2-chloroethyl) orthophosphate
-tris(2-chloroethyl)phosphate",115-96-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-meti-0012e.html,"JP_CHRIP:
-In two reports on skin irritation tests (OECD TG 404) using rabbits, it is reported that slight erythema was observed, but this resolved within 24 hours (EU-RAR (2009)). In addition, it is described that in a skin irritation test using rabbits, as the result of applying 0.5 mL of this substance for 4 hours under a semi-occlusive dressing, slight erythema was observed in all animals on Day 1 after application, but there were no signs of irritation (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), EHC 209 (1998)).
-From the above, this substance was classified as ""Not classified"" (Category 3 in UN GHS classification). Based on the added information, the category was changed according to the GHS Classification Guidance for the Japanese Government.",Provided,JP_CHRIP,1,ClCCOP(=O)(OCCCl)OCCCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.095I,J-GLOBAL,O=P(OCCCl)(OCCCl)OCCCl,Train,1,2702,training
-"EU_REACH:
-(1r,1's,4r,4'r)-4-ethenyl-4'-propyl-1,1'-bi(cyclohexane)",,116020-44-1,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7219/7/4/2/?documentUUID=c991cd07-3a4f-46c3-8daa-6f5a438e7d0a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2CCC(CC2)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/12097469,PubChem,C=CC1CCC(C2CCC(CCC)CC2)CC1,Train,1,2702,training
-"EU_REACH:
-methyl 1-(2-chloroacetyl)-2-oxo-2,3-dihydro-1H-indole-6-carboxylate",,1160293-25-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26465/7/4/2/?documentUUID=83b2bbd2-662e-42ac-9734-8761663d1e87,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=CC2=C(CC(=O)N2C(=O)CCl)C=C1,https://pubchem.ncbi.nlm.nih.gov/compound/42634136,PubChem,COC(=O)c1ccc2c(c1)N(C(=O)CCl)C(=O)C2,Train,1,2702,training
-"EU_REACH:
-hexachloropropan-2-one",,116-16-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17343/7/4/2/?documentUUID=0dc9628b-4cad-4b06-af67-d81b5e5cd83d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(=O)(C(Cl)(Cl)Cl)C(Cl)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/8303,PubChem,O=C(C(Cl)(Cl)Cl)C(Cl)(Cl)Cl,Train,1,2702,training
-"EU_CLP:
-2-(2-(2-hydroxyethoxy)ethyl)-2-aza-bicyclo[2.2.1]heptane",,116230-20-7,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1CC2CC1CN2CCOCCO,https://pubchem.ncbi.nlm.nih.gov/compound/19854916,PubChem,OCCOCCN1CC2CCC1C2,Test,1,2702,training
-"NZ_CCID:
-2-Methylbutyric acid",,116-53-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7F2DD93B-C132-4BFB-8960-83C145F6A991,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCC(C)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/8314,PubChem,CCC(C)C(=O)O,Train,1,2702,training
-"NZ_CCID:
-Methyl dichloroacetate",,116-54-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/41441F41-8F36-4226-A253-0A0A7F84814F,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,COC(=O)C(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/8315,PubChem,COC(=O)C(Cl)Cl,Train,1,2702,training
-"NZ_CCID:
-1-Naphthalenesulphonic acid, 4-amino-3-hydroxy-",,116-63-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F61F0598-41CB-4C17-84FB-296A717ABE89,,,NZ_CCID,1,C1=CC=C2C(=C1)C(=CC(=C2N)O)S(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/8316,PubChem,Nc1c(O)cc(S(=O)(=O)O)c2ccccc12,Train,1,2702,training
-"EU_REACH:
-1,4-bis(mesitylamino)anthraquinone",,116-75-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5736/7/4/2/?documentUUID=db4b62d3-46d7-4889-97ef-71a724c00b96,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C(=C1)C)NC2=C3C(=C(C=C2)NC4=C(C=C(C=C4C)C)C)C(=O)C5=CC=CC=C5C3=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/61042,PubChem,Cc1cc(C)c(Nc2ccc(Nc3c(C)cc(C)cc3C)c3c2C(=O)c2ccccc2C3=O)c(C)c1,Train,1,2702,training
-"EU_REACH:
-methyl (3E)-3-[methoxy(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate",,1168150-46-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27187/7/4/2/?documentUUID=cc2dbdf9-a473-473a-841b-57550a10a424,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CO/C(=C/1\C2=C(C=C(C=C2)C(=O)OC)NC1=O)/C3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/42634134,PubChem,COC(=O)c1ccc2c(c1)NC(=O)/C2=C(/OC)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-1,8-Dihydroxyanthraquinone",,117-10-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3C55C8D2-47C2-4275-BB5C-5D6CA0E5868C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]",,NZ_CCID,1,C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=CC=C3O,https://pubchem.ncbi.nlm.nih.gov/compound/2950,PubChem,O=C1c2cccc(O)c2C(=O)c2c(O)cccc21,Train,1,2702,training
-"EU_REACH:
-4-chloro-1,3-dihydro-2-benzofuran-1,3-dione",,117-21-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11567/7/4/2/?documentUUID=e6c0a0d5-dd5c-4032-b7e6-1a4b0a021f1e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=C(C(=C1)Cl)C(=O)OC2=O,https://pubchem.ncbi.nlm.nih.gov/compound/67014,PubChem,O=C1OC(=O)c2c(Cl)cccc21,Train,1,2702,training
-"EU_REACH:
-2-(naphthalene-2-sulfonamido)benzoic acid",,117309-52-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23982/7/4/2/?documentUUID=01d7ab5c-6f8a-47e9-a11a-2d8469c71732,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)NC3=CC=CC=C3C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/4798771,PubChem,O=C(O)c1ccccc1NS(=O)(=O)c1ccc2ccccc2c1,Train,1,2702,training
-"NZ_CCID:
-Diphenylacetic acid",,117-34-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/64782B52-6FDA-4698-A760-40D9276C2BD0,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/8333,PubChem,O=C(O)C(c1ccccc1)c1ccccc1,Train,1,2702,training
-"EU_REACH:
-methyl (2E)-3-methoxy-2-[2-({[6-(trifluoromethyl)pyridin-2-yl]oxy}methyl)phenyl]acrylate",,117428-22-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21001/7/4/2/?documentUUID=349e85bc-f90d-4892-8207-a003afb591e1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CO/C=C(\C1=CC=CC=C1COC2=CC=CC(=N2)C(F)(F)F)/C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/11285653,PubChem,CO/C=C(/C(=O)OC)c1ccccc1COc1cccc(C(F)(F)F)n1,Train,1,2702,training
-"EU_REACH:
-Methyl-2-(2-chloromethylphenyl)-3-methoxy-2-acrylate",,117428-95-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11725/7/4/2/?documentUUID=e967bddc-7d24-4f00-8e87-91e69767ed1d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CO/C=C(/C1=CC=CC=C1CCl)\C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/10130990,PubChem,CO/C=C(\C(=O)OC)c1ccccc1CCl,Train,1,2702,training
-"EU_REACH:
-methyl (3E)-1-(2-chloroacetyl)-3-[methoxy(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate",,1174335-83-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26473/7/4/2/?documentUUID=3d05fb27-909c-4bd2-ae30-cbf16acf2100,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CO/C(=C/1\C2=C(C=C(C=C2)C(=O)OC)N(C1=O)C(=O)CCl)/C3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/42634135,PubChem,COC(=O)c1ccc2c(c1)N(C(=O)CCl)C(=O)/C2=C(/OC)c1ccccc1,Test,1,2702,training
-"EU_REACH:
-2-[2-(carboxymethyl)phenoxy]-3,4-dimethylbenzoic acid",,117570-93-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2727/7/4/2/?documentUUID=edda16c9-f94b-4696-a119-5846d400d09d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(=C(C=C1)C(=O)O)OC2=CC=CC=C2CC(=O)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/14885557,PubChem,Cc1ccc(C(=O)O)c(Oc2ccccc2CC(=O)O)c1C,Train,1,2702,training
-"JP_CHRIP:
-2,3-Dichloro-1.4-naphthoquinone
-
-NZ_CCID:
-Dichlone","JP_CHRIP:
-1,4-Naphthalenedione, 2,3-dichloro-
-2,3-Dichloro-1,4-naphthoquinone (synonym:dichlone )
-
-NZ_CCID:
-1,4-Naphthalenedione, 2,3-dichloro-, 2,3-DICHLORO-1,4-NAPHTHAQUINONE, 2,3-DICHLORONAPHTHOQUINONE, DICHLORONAPHTHOQUINONE, Phygon, Sanquinon",117-80-6,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0188e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AEA934CC-1BEC-4EE4-9084-B6F41608EA4F","JP_CHRIP:
-The substance was reported to irritate skin (HSDB (2006)). In the rabbit test, acute dermal exposure of the substance caused skin irritation (HSDB (2006)). The substance was classified as ""Skin irrit 2"" by EC (Annex IV) (EC-JRC (ESIS) (Access on Oct. 2010)). Based on these documents, the substance was classified as Category 2.
-
-NZ_CCID:
-Skin Irritation
-R-PHRASE: R 36/38. [N-CLASS]
-Eye Irritation
-R-PHRASE: R 36/38. [N-CLASS]",,"JP_CHRIP, NZ_CCID",2,ClC1=C(Cl)C(=O)c2ccccc2C1=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.473B,J-GLOBAL,O=C1C(Cl)=C(Cl)C(=O)c2ccccc21,Train,1,2702,training
-"JP_CHRIP:
-Bis(2-ethylhexyl) phthalate","JP_CHRIP:
-Bis(2-ethylhexyl) phthalate
-Bis-(2-ethylhexyl)phthalate
-DEHP
-Di(2-ethylhexy)phthalate
-Di(2-ethylhexyl) phthalate
-Di(2-ethylhexyl)phthalate
-di-2-ethylhexyl phthalate
-Diethylhexyl phthalate
-dioctyl benzene-1,2-dicarboxylate
-Dioctyl phthalate
-Dioctylphthalate
-DOP; DEHP",117-81-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2081e.html,"JP_CHRIP:
-There are 2 reports of skin irritation tests (OECD TG 404) with rabbits. In one study, neither erythema nor edema was observed, and the irritation score was 0 (EU-RAR (2003)). In the other study, although slight erythema (3/3 animals) at 1 hour after application, significant erythema (1/3 animals) at 24 hours after application, and slight erythema (3/3 of the animals) at 48 hours after application were observed, they resolved 8 days after application, therefore, it was judged to be slightly irritating (EU-RAR (2003)). In addition, in another skin irritation test with rabbits (FDA recommended method, GLP-compliant), after 24-hour application of this substance, slight to moderate skin reaction was observed but this disappeared after 48 hours, therefore, it was judged to be slightly irritating (EU-RAR (2003)). Moreover, there is a report that in humans, the undiluted liquid of this substance was applied occlusively to the backs of 23 subjects for 7 days and reapplied on the 10th day, and no skin reaction was observed (EU-RAR (2003)). From the above results, it was classified as ""Not classified"" (Category 3 in UN GHS classification). The category was changed according to the revised GHS classification guidance for the Japanese government.",Provided,JP_CHRIP,1,CCCCC(CC)COC(=O)c1ccccc1C(=O)OCC(CC)CCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.909B,J-GLOBAL,CCCCC(CC)COC(=O)c1ccccc1C(=O)OCC(CC)CCCC,Train,1,2702,training
-"EU_REACH:
-N-(3,5-dichloro-4-ethyl-2-hydroxyphenyl)hexadecanamide",,117827-06-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6149/7/4/2/?documentUUID=b0b6bcec-57f4-4f69-ae45-859a4752f0f9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCC(=O)NC1=CC(=C(C(=C1O)Cl)CC)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/14344747,PubChem,CCCCCCCCCCCCCCCC(=O)Nc1cc(Cl)c(CC)c(Cl)c1O,Train,1,2702,training
-"EU_REACH:
-trans-5-butyl-2-(3',3'',4'',5''-tetrafluoro-1,1':4',1''-terphenyl-4-yl)-1,3-dioxane",,1182844-21-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29749/7/4/2/?documentUUID=681ee1e5-13fa-4a70-a8de-02f217f299fa,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC1COC(OC1)C2=CC=C(C=C2)C3=CC(=C(C=C3)C4=CC(=C(C(=C4)F)F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/132042669,PubChem,CCCCC1COC(c2ccc(-c3ccc(-c4cc(F)c(F)c(F)c4)c(F)c3)cc2)OC1,Train,1,2702,training
-"EU_REACH:
-hexaphenoxy-1,3,5,2λ⁵,4λ⁵,6λ⁵-triazatriphosphinine",,1184-10-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30500/7/4/2/?documentUUID=2b6d5add-28a9-4284-a647-9d182b19f902,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)OP2(=NP(=NP(=N2)(OC3=CC=CC=C3)OC4=CC=CC=C4)(OC5=CC=CC=C5)OC6=CC=CC=C6)OC7=CC=CC=C7,https://pubchem.ncbi.nlm.nih.gov/compound/136917,PubChem,c1ccc(OP2(Oc3ccccc3)=NP(Oc3ccccc3)(Oc3ccccc3)=NP(Oc3ccccc3)(Oc3ccccc3)=N2)cc1,Train,1,2702,training
-"EU_REACH:
-5-chloro-1,3-dihydro-2-benzofuran-1,3-dione",,118-45-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12546/7/4/2/?documentUUID=d508a43e-401a-4f86-9f4a-9acb086633a2,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=C(C=C1Cl)C(=O)OC2=O,https://pubchem.ncbi.nlm.nih.gov/compound/67044,PubChem,O=C1OC(=O)c2cc(Cl)ccc21,Train,1,2702,training
-"EU_REACH:
-4-(3,5-dichlorobenzamido)-3-hydroxybenzoic acid",,1184581-58-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27410/7/4/2/?documentUUID=6c2ec289-2390-485b-bdce-b97314f46345,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C=C1C(=O)O)O)NC(=O)C2=CC(=CC(=C2)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/60825179,PubChem,O=C(O)c1ccc(NC(=O)c2cc(Cl)cc(Cl)c2)c(O)c1,Train,1,2702,training
-"ChemSkin:
-Benzyl salicylate",,118-58-1,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,C1=CC=C(C=C1)COC(=O)C2=CC=CC=C2O,https://pubchem.ncbi.nlm.nih.gov/compound/8363,PubChem,O=C(OCc1ccccc1)c1ccccc1O,Test,1,2702,training
-"NZ_CCID:
-Ethyl salicylate",,118-61-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/035FB9DF-1828-4EE8-AB29-EF8C5CAC952A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCOC(=O)C1=CC=CC=C1O,https://pubchem.ncbi.nlm.nih.gov/compound/8365,PubChem,CCOC(=O)c1ccccc1O,Train,1,2702,training
-"EU_REACH:
-1,4-diethyl 2-(2-oxopropyl)butanedioate",,1187-74-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1510/7/4/2/?documentUUID=d1ca5732-c110-4546-8901-d12c33bd3213,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CC(CC(=O)C)C(=O)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/5463816,PubChem,CCOC(=O)CC(CC(C)=O)C(=O)OCC,Train,1,2702,training
-"ChemSkin:
-4,4′-Methylenebis(2,6-di-tert-butylphenol)",,118-82-1,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CC2=CC(=C(C(=C2)C(C)(C)C)O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/8372,PubChem,CC(C)(C)c1cc(Cc2cc(C(C)(C)C)c(O)c(C(C)(C)C)c2)cc(C(C)(C)C)c1O,Test,1,2702,training
-"NZ_CCID:
-2-Propenoic acid, 2-methyl-, 1-methyl-1,3-propanediyl ester",,1189-08-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/231D54DF-86CC-4D1C-96FA-667750422F39,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,CC(CCOC(=O)C(=C)C)OC(=O)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/70916,PubChem,C=C(C)C(=O)OCCC(C)OC(=O)C(=C)C,Train,1,2702,training
-"NZ_CCID:
-2-Chlorobenzoic acid","NZ_CCID:
-o-chlorobenzoic acid",118-91-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/99557ED5-8C2A-4BAA-96B0-CE2E2A0A5D9A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)C(=O)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/8374,PubChem,O=C(O)c1ccccc1Cl,Train,1,2702,training
-"NZ_CCID:
-Ethanone, 1-(2-hydroxyphenyl)-",,118-93-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/549B956F-38EE-47DD-92AF-BF9250263BE9,,,NZ_CCID,1,CC(=O)C1=CC=CC=C1O,https://pubchem.ncbi.nlm.nih.gov/compound/8375,PubChem,CC(=O)c1ccccc1O,Train,1,2702,training
-"JP_CHRIP:
-2,4,6-Trinitrotoluene","JP_CHRIP:
-1-Methyl-2,4,6-trinitrobenzene
-2,4,6-Trinitrotoluene
-2-Methyl-1,3,5-trinitrobenzene
-TNT",118-96-7,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2018e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified in Category 2 from (1) - (3).
-
-[Evidence Data]
-(1) Exposure to this substance may cause skin irritation in humans (ACGIH (7th, 2019), IARC 65 (1996)).
-(2) Exposure to this substance is well known to irritate the skin or eye (Patty (6th, 2012), HSDB (Access on April 2020)).
-(3) It was moderately irritating in a skin irritation test in which this substance (500 mg) was applied to rabbits for 24 hours (GESTIS (Access on April 2020)).
-
-[Reference Data, etc.]
-(4) It is reported that it was not irritating in a skin irritation test with rabbits (equivalent to OECD TG 404) in which 50% paste of this substance was applied (REACH registration dossier (Access on May 2020)).
-(6) Skin disease, hematopoietic disorder such as hemolytic anemia and aplastic anemia, or liver disease due to work involving exposure to trinitrotoluene was designated as simple chemical substances or compounds (including alloys) designated by the Minister of Health, Labour and Welfare or disease designated by the Minister of Health, Labour and Welfare based on Appended Table 1-2, (iv) 1 of the Ordinance for Enforcement of the Labor Standards Act (Notification No. 33).",Provided,JP_CHRIP,1,Cc1c(cc(cc1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.477E,J-GLOBAL,Cc1c([N+](=O)[O-])cc([N+](=O)[O-])cc1[N+](=O)[O-],Train,1,2702,training
-"EU_REACH:
-1-(3,5-dichloro-4-fluorophenyl)-2,2,2-trifluoroethanone",,1190865-44-1,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32348/7/4/2/?documentUUID=cbd17be7-29ac-45a8-ba17-20b98a1c2040,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(C=C(C(=C1Cl)F)Cl)C(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/75530023,PubChem,O=C(c1cc(Cl)c(F)c(Cl)c1)C(F)(F)F,Train,1,2702,training
-"NZ_CCID:
-1,4-Butanedithiol",,1191-08-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B3506AB2-3F69-4378-82AB-7F39C6488CCC,,,NZ_CCID,1,C(CCS)CS,https://pubchem.ncbi.nlm.nih.gov/compound/79148,PubChem,SCCCCS,Train,1,2702,training
-"EU_REACH:
-3-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzene-1-sulfonic acid",,119-17-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13434/7/4/2/?documentUUID=7af4c05a-40b5-42fd-a96d-e79f14d129dd,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=NN(C(=O)C1)C2=CC(=CC=C2)S(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/67060,PubChem,CC1=NN(c2cccc(S(=O)(=O)O)c2)C(=O)C1,Train,1,2702,training
-"JP_CHRIP:
-2,6-Dichlorobenzonitrile; Dichlobenil","JP_CHRIP:
-2,6-Dichlorobenzonitrile
-2,6-Dichlorophenylcyanide
-DBN",1194-65-6,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2041e.html,"JP_CHRIP:
-[Rationale for the Classification]
-Based on (1)-(4), it was classified as ""Not classified.""
-
-[Evidence Data]
-(1) In a skin irritation test in which this substance (85.3% formulation) was administered to rabbits according to EPA TG81-5 (corresponding to OECD TG 404), it is reported not to be a dermal irritant (EPA Pesticide (1998), REACH registration dossier (Access on August 2019)).
-(2) In a skin irritation test with rabbits, no irritation was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014)).
-(3) In a skin irritation test with rabbits (4-hour application), the scores 30-60 minutes after application and 24/48/72 hours after were all 0 and no irritation was observed (Agricultural Chemicals Times supplement Vol.10 (Japan Crop Protection Association, 1991)).
-(4) This substance was not irritating to the skin of rabbits (JMPR (2014)).",Provided,JP_CHRIP,1,Clc1cccc(Cl)c1C#N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.365K,J-GLOBAL,N#Cc1c(Cl)cccc1Cl,Train,1,2702,training
-"EU_REACH:
-2-tert-butyl-6-[(3-tert-butyl-2-hydroxy-5-methylphenyl)methyl]-4-methylphenol",,119-47-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13380/7/4/2/?documentUUID=acbbd449-9b9e-4a13-8efd-cb8530505947,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C(=C1)C(C)(C)C)O)CC2=C(C(=CC(=C2)C)C(C)(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/8398,PubChem,Cc1cc(Cc2cc(C)cc(C(C)(C)C)c2O)c(O)c(C(C)(C)C)c1,Train,1,2702,training
-"KR_NCIS:
-Dodecyl or tetradecyl N-(2,2,6,6-tetramethyl-4-piperidinyl)-β-alanine","KR_NCIS:
-4-[[2-(Lauryloxycarbonyl)ethyl]amino]-2,2,6,6-tetramethylpiperidine; N-(2,2,6,6-tetramethyl-4-piperidinyl)-b-Alanine, dodecyl ester; β-Alanine, N-(2,2,6,6-tetramethyl-4-piperidinyl)-, dodecyl ester",119530-69-7,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCCCCCCCCCCCOC(=O)CCNC1CC(NC(C1)(C)C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/3086594,PubChem,CCCCCCCCCCCCOC(=O)CCNC1CC(C)(C)NC(C)(C)C1,Train,1,2702,training
-"KR_NCIS:
-Dodecyl or tetradecyl N-(2,2,6,6-tetramethyl-4-piperidinyl)-β-alanine","KR_NCIS:
-4-[[2-(Myristyloxycarbonyl)ethyl]amino]-2,2,6,6-tetramethylpiperidine; b-Alanine, N-(2,2,6,6-tetramethyl-4-piperidinyl)-, tetradecyl ester; β-Alanine, N-(2,2,6,6-tetramethyl-4-piperidinyl)-, tetradecyl ester",119530-70-0,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCCCCCCCCCCCCCOC(=O)CCNC1CC(NC(C1)(C)C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/3086595,PubChem,CCCCCCCCCCCCCCOC(=O)CCNC1CC(C)(C)NC(C)(C)C1,Train,1,2702,training
-"EU_REACH:
-diphenylmethanone
-
-JP_CHRIP:
-Benzophenone","JP_CHRIP:
-Benzoylbenzene
-Diphenyl ketone
-Phenyl ketone",119-61-9,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13823/7/4/2/?documentUUID=5e9a31d6-89a6-44b3-a490-d1f15501ac72
-JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-mhlw-2010.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-【分類根拠】
-（１）より、区分に該当しない。なお、新たな知見に基づき、分類結果を変更した。
-
-【根拠データ】
-（１）ウサギ（n=4）を用いた皮膚刺激性試験（OECD TG 404、GLP、2～100％（原液）、半閉塞、4時間適用、72時間観察）において、濃度100％まで皮膚刺激性の徴候は認められなかったとの報告がある（AICIS IMAP (2015)、REACH登録情報 (Accessed Dec. 2021)）。",Provided,"EU_REACH, JP_CHRIP",2,O=C(c1ccccc1)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.481C,J-GLOBAL,O=C(c1ccccc1)c1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-1,2,3,4-tetrahydronaphthalene
-
-NZ_CCID:
-1,2,3,4-Tetrahydronaphthalene","JP_CHRIP:
-Naphthalene, 1,2,3,4-tetrahydro-
-Tetrahydronaphthalene
-Tetralin
-
-NZ_CCID:
-tetrahydronaphthalene",119-64-2,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0103e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3BAA247C-41BF-45F2-8AA6-DA612DC83C2C","JP_CHRIP:
-In a four-hour skin irritation study according to OECD TG 404 using rabbits, the substance caused moderate irritation with Draize scores of 3.11 for erythema and 1.56 for edema, and the effects were not completely reversible within 14 days (SIDS (accessed in August 2008)). In addition, since its EU Risk Phrase is R36/38, which indicates that its hazard potential is equivalent to Category 2, the substance was classified into Category 2.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",Provided,"JP_CHRIP, NZ_CCID",2,C1CCc2ccccc2C1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.002H,J-GLOBAL,c1ccc2c(c1)CCCC2,Train,1,2702,training
-"EU_REACH:
-1-[2-chloro-4-(4-chlorophenoxy)phenyl]ethanone",,119851-28-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2113/7/4/2/?documentUUID=3e861be4-4e9e-4d56-89b6-e094e09dbd15,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C1=C(C=C(C=C1)OC2=CC=C(C=C2)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/677479,PubChem,CC(=O)c1ccc(Oc2ccc(Cl)cc2)cc1Cl,Train,1,2702,training
-"KR_NCIS:
-3,3'-Dimethoxy-[1,1'-biphenyl]-4,4'-diamine","KR_NCIS:
-3,3'-Dimethoxybenzidine",119-90-4,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,COC1=C(C=CC(=C1)C2=CC(=C(C=C2)N)OC)N,https://pubchem.ncbi.nlm.nih.gov/compound/8411,PubChem,COc1cc(-c2ccc(N)c(OC)c2)ccc1N,Train,1,2702,training
-"EU_REACH:
-4-(4-hydroxybenzoyloxy)-3-methylphenyl 4-hydroxybenzoate",,119959-84-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33665/7/4/2/?documentUUID=026b0aab-161d-435f-bbdb-6ab724102de8,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=CC(=C1)OC(=O)C2=CC=C(C=C2)O)OC(=O)C3=CC=C(C=C3)O,https://pubchem.ncbi.nlm.nih.gov/compound/10992120,PubChem,Cc1cc(OC(=O)c2ccc(O)cc2)ccc1OC(=O)c1ccc(O)cc1,Train,1,2702,training
-"NZ_CCID:
-Anthracene
-
-US_HSDB:
-Anthracene",,120-12-7,Cat 2,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/19395CAD-5829-4D1C-9CAC-D948B5663A23
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/702",,,"NZ_CCID, US_HSDB",2,C1=CC=C2C=C3C=CC=CC3=CC2=C1,https://pubchem.ncbi.nlm.nih.gov/compound/8418,PubChem,c1ccc2cc3ccccc3cc2c1,Train,1,2702,training
-"EU_REACH:
-480-680-7",,120128-90-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13705/7/4/2/?documentUUID=1503ef99-75ae-454c-882e-2968022b13ea,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[N+](C)(CCCNC=O)CC(=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/5287757,PubChem,C[N+](C)(CCCNC=O)CC(=O)[O-],Train,1,2702,training
-"JP_CHRIP:
-3,4-Dimethoxybenzaldehyde
-
-NZ_CCID:
-3,4-Dimethoxybenzaldehyde","JP_CHRIP:
-3,4-dimethoxybenzaldehyde",120-14-9,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0085e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DC3095BA-665C-4165-A099-853732721DC4","JP_CHRIP:
-It was classified in Category 2 because it is described that it was moderately irritating in a test by a 24-hour occlusive application of 500 mg of the undiluted test substance to the rabbit skin (RTECS (1997): the original article, Food and Cosmetics Toxicology: 13, 923, 1975), and the description in the original article was confirmed.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,"JP_CHRIP, NZ_CCID",2,COc1ccc(C=O)cc1OC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J9.907D,J-GLOBAL,COc1ccc(C=O)cc1OC,Train,1,2702,training
-"NZ_CCID:
-2-(3,4-Dimethoxyphenyl) ethylamine","NZ_CCID:
-3,4-dimethoxyphenethylamine",120-20-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E54028E9-9F8B-41E3-A438-398D438E83D1,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 41 [Company Data]",,NZ_CCID,1,COC1=C(C=C(C=C1)CCN)OC,https://pubchem.ncbi.nlm.nih.gov/compound/8421,PubChem,COc1ccc(CCN)cc1OC,Train,1,2702,training
-"AU_HCIS:
-Phenol, 4-chloro-2-(phenylmethyl)-
-
-EU_REACH:
-clorofene
-
-JP_CHRIP:
-2-Benzyl-4-chlorophenol; Clorofene",,120-32-1,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5542
-EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25019/7/4/2/?documentUUID=6df80d37-8d8b-436c-9b79-fc2c6ed37386
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-0003e.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-[Rationale for the Classification]
-Based on (1), it was classified in Category 2.
-
-[Evidence Data]
-(1) In a skin irritation test with rabbits according to OECD TG 404, the average scores at 24-72 hours in 3 animals were 2.7-3.0 for erythema and 4 for edema, and on Day 14, the score was 0 in all animals. However, scar-like tissue was observed after 21 days, but apparent reversibility was reported (REACH registration dossier (Access on June 2019)).
-
-[Reference Data, etc.]
-(2) It was classified as ""Skin Irrit. 2 (H315)"" in the EU CLP classification (EU CLP classification (Access on June 2019)).",Provided,"AU_HCIS, EU_REACH, JP_CHRIP",3,Oc1ccc(Cl)cc1Cc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J39.614A,J-GLOBAL,Oc1ccc(Cl)cc1Cc1ccccc1,Train,1,2702,training
-"EU_REACH:
-3-amino-4-methoxy-N-phenylbenzamide",,120-35-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11279/7/4/2/?documentUUID=1b8e5b99-8ae3-4a31-848c-da5b45a24817,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2)N,https://pubchem.ncbi.nlm.nih.gov/compound/8426,PubChem,COc1ccc(C(=O)Nc2ccccc2)cc1N,Train,1,2702,training
-"JP_CHRIP:
-dichlorprop (ISO); 2-(2,4-dichlorophenoxy) propionic acid
-
-NZ_CCID:
-Dichlorprop","JP_CHRIP:
-2,4-DP
-2-(2,4-Dichlorophenoxy)propionic acid
-Dichloroprop
-Dichlorprop",120-36-5,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0177e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FF7EE02F-51B3-4D63-A17A-5EB2C0C2A697","JP_CHRIP:
-A Draize test using rabbits found the substance irritating (IUCLID (2000)), and another Draize test using rabbits that received a racemic mixture found the substance to be a mild to moderate irritant (HSDB (2008)). In addition to these results, since the substance is rated as R38 in the EU classification, it was classified into Category 2.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Irritating
-REFERENCE SOURCE: AH Marks and Company Ltd Bradford (27) [""Report on the Study of the Irritation to the Intact and Abraded Dorsal Skin of the White Rabbit Based on Draize of 2,4-DP (Dichlorprop)"" Study by BASF, Document No. 83/186, for the TPH Committee.(1983)]
-[IUCLID 2000]
-R-PHRASE: R 38 Irritating to skin. [IUCLID 2000] [NCLASS]
-Eye Irritation
-R-PHRASE: R 41 Risk of serious damage to eyes.[IUCLID 2000] [NCLASS]",,"JP_CHRIP, NZ_CCID",2,CC(Oc1ccc(Cl)cc1Cl)C(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.254I,J-GLOBAL,CC(Oc1ccc(Cl)cc1Cl)C(=O)O,Train,1,2702,training
-"NZ_CCID:
-Diethanolamine lauroylamide","NZ_CCID:
-Diethanollauramide, Dodecanamide, N,N-bis(2-hydroxyethyl)-, Lauramide dea, Lauric acid diethanolamide, Lauric diethanolamide, Lauroyl diethanolamide, N,N-Bis(2-hydroxyethyl)dodecanamide, N,N-Di(2-hydroxyethyl)lauramide",120-40-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0B14CF3B-320D-43D2-B144-7E287A0ACFA2,"NZ_CCID:
-Skin Irritation
-SPECIES:
-RESULT: Lauramide DEA...mild to severe skin irritant.
-REFERENCE SOURCE: TA:J Am Coll Toxicol PG:415-54 YR:1986 IP:5 VI:5
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Aqueous emulsions of 1.0, 5.0, and 25% lauramide DEA in the unwashed compared to washed eyes of rabbits (three/group) showed no to slight effects (some conjunctival irritation), disappearing within 24 hours following exposure to the 1.0% emulsion; slight to moderate effects (appreciable conjunctival irritation and superficial corneal injury with no vision loss) disappearing within a week following exposure to the 5.0% emulsion; and moderate to severe corneal and conjunctival injury with some vision impairment after exposure to the 25% emulsion.
-REFERENCE SOURCE:
-[http://www.epa.gov/dfe/pubs/garment/ctsa/docs/appc.pdf]",,NZ_CCID,1,CCCCCCCCCCCC(=O)N(CCO)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/8430,PubChem,CCCCCCCCCCCC(=O)N(CCO)CCO,Train,1,2702,training
-"EU_REACH:
-benzyl benzoate
-
-JP_CHRIP:
-benzyl benzoate","JP_CHRIP:
-Benzoic acid, phenylmethyl ester
-Benzyl benzenecarboxylate",120-51-4,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13634/7/4/2/?documentUUID=f0f6e844-bd09-4c6b-a62d-097bc9b901b2
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0178e.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-In Draize tests using rabbits, the average scores of the treated animals that received 4-hour applications of this substance for 3 days were 0 to 1.58 (ECETOC TR 66 (1995)). Based on these results, the substance was classified into the ""Not classified"" category.",Provided,"EU_REACH, JP_CHRIP",2,O=C(OCc1ccccc1)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.327I,J-GLOBAL,O=C(OCc1ccccc1)c1ccccc1,Train,1,2702,training
-"EU_REACH:
-2-[2-(benzoyloxy)ethoxy]ethyl benzoate",,120-55-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5156/7/4/2/?documentUUID=b5c20315-fe6b-4262-ad93-9eb0db0cab85,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C(=O)OCCOCCOC(=O)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/8437,PubChem,O=C(OCCOCCOC(=O)c1ccccc1)c1ccccc1,Train,1,2702,training
-"US_HSDB:
-Isosafrole",,120-58-1,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/2862,,,US_HSDB,1,C/C=C/C1=CC2=C(C=C1)OCO2,https://pubchem.ncbi.nlm.nih.gov/compound/637796,PubChem,C/C=C/c1ccc2c(c1)OCO2,Train,1,2702,training
-"JP_CHRIP:
-Dimethyl terephthalate","JP_CHRIP:
-Dimethyl 1,4-benzenedicarboxylate
-Dimethyl p-phthalate",120-61-6,NC,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-mhlw-2007.html,"JP_CHRIP:
-【分類根拠】
-（１）～（３）より、区分に該当しない（国連分類基準の区分3）。
-
-【根拠データ】
-（１）モルモットを用いた皮膚刺激性試験において、軽度の刺激性を示したとの報告がある（NITE初期リスク評価書 (2008)）。
-（２）ウサギ（n = 6）を用いた皮膚刺激性試験（OECD TG 404相当、半閉塞、4時間適用、72時間観察）において、皮膚一次刺激指数（PII）は0であった（紅斑・痂皮スコア：0/0/0/0/0/0、浮腫スコア：0/0/0/0/0/0）との報告がある（REACH登録情報 (Accessed Nov. 2021)）。
-（３）ウサギを用いた皮膚刺激性試験（4時間適用、24時間観察）において、観察期間中に刺激はみられなかったとの報告がある（産衛学会許容濃度の暫定値の提案理由書 (2020)）。",Provided,JP_CHRIP,1,COC(=O)c1ccc(cc1)C(=O)OC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.003F,J-GLOBAL,COC(=O)c1ccc(C(=O)OC)cc1,Train,1,2702,training
-"JP_CHRIP:
-2-Methoxy-5-methylaniline","JP_CHRIP:
-2-Methoxy-5-methylaniline
-1-amino-2-methoxy-5-methylbenzene
-3-Amino-para-cresol methyl ether
-4-Methyl-2-aminoanisole
-5-Methyl-ortho-anisidine
-Benzenamine, 2-methoxy-5-methyl-
-para-Cresidine",120-71-8,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-2032e.html,"JP_CHRIP:
-It is described in DFGOT vol. 4 (1992) that it was moderately irritating to rabbit skin, although exposure time is unknown, and it is described in HSDB (Access on July 2013) that there was skin irritation. Therefore, it was classified in Category 2.",,JP_CHRIP,1,COc1ccc(C)cc1N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.331G,J-GLOBAL,COc1ccc(C)cc1N,Train,1,2702,training
-"AU_HCIS:
-1,2-Benzenediol
-
-JP_CHRIP:
-Catechol; Pyrocatechol
-
-NZ_CCID:
-Pyrocatechol
-
-US_HSDB:
-CATECHOL","AU_HCIS:
-1,2-dihydroxybenzene
-pyrocatechol
-
-JP_CHRIP:
-1,2-Benzenediol
-1,2-Dihydroxybenzene
-Benzene-1,2-diol
-Brenzcatechin
-Catechol
-Pyrocatechin
-
-NZ_CCID:
-1,2-Benzenediol, 1,2-Dihydroxybenzene, 2-Hydroxyphenol, Catechol (phenol), o-Benzenediol, o-Dihydroxybenzene, o-Dioxybenzene, o-Hydroquinone, o-Hydroxyphenol, o-Phenylenediol, Oxyphenic acid, Phthalhydroquinone, Pyrocatechin, Pyrocatechine",120-80-9,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=393
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-2016e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/174FEB61-4760-4813-B63C-1DAA46E9B99A
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1436","JP_CHRIP:
-In a primary skin irritation test (US Federal Register (1961)) by 24-hour occlusive application of 0.5 g of this substance to (six) rabbits, moderate erythema and slight edema were seen in all animals after 24 hours, but the signs were diminished after 72 hours and disappeared after 14 days, and it was assessed as moderate irritation (Initial Risk Assessment Report Ver.1.0 No.145 (NITE, CERI, NEDO, 2008)). Therefore, it was classified in Category 2.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,"AU_HCIS, JP_CHRIP, NZ_CCID, US_HSDB",4,Oc1ccccc1O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.921A,J-GLOBAL,Oc1ccccc1O,Train,1,2702,training
-"EU_CLP:
-1,2,4-trichlorobenzene",,120-82-1,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC(=C(C=C1Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/13,PubChem,Clc1ccc(Cl)c(Cl)c1,Test,1,2702,training
-"JP_CHRIP:
-2,4-Dichlorophenol
-
-NZ_CCID:
-2,4-Dichlorophenol","JP_CHRIP:
-2,4-DCP
-Phenol, 2,4-dichloro-",120-83-2,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-meti-0013e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/31BDD982-C6FC-4700-A595-FEF5B93A0560","JP_CHRIP:
-It is reported that strong irreversible necrosis was observed after applying this substance (80% aqueous solution) to rabbit skin for 15 minutes (SIDS (2008)). In addition, many cases of deaths of workers exposed to this substance were reported (SIDS (2008), Environmental Risk Assessment for Chemical Substances (Ministry of the Environment) Vol. 8 (2010)). It is described that contact with only 1% of the body surface may lead to death. From the above, this substance was classified in Category 1. Besides, it is classified as ""Skin Corr. 1B H 314"" in the EU CLP classification (ECHA C&L Inventory (Access on June 2015)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,Oc1ccc(Cl)cc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.005B,J-GLOBAL,Oc1ccc(Cl)cc1Cl,Train,1,2702,training
-"EU_CLP:
-cyclopentanone",,120-92-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1CCC(=O)C1,https://pubchem.ncbi.nlm.nih.gov/compound/8452,PubChem,O=C1CCCC1,Test,1,2702,training
-"KR_NCIS:
-1-Methylpyrrolidine",,120-94-5,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CN1CCCC1,https://pubchem.ncbi.nlm.nih.gov/compound/8454,PubChem,CN1CCCC1,Train,1,2702,training
-"EU_REACH:
-2,4-bis(2-methylbutan-2-yl)phenol",,120-95-6,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17246/7/4/2/?documentUUID=6342992c-8ca5-4e1c-91c8-4f2743f2135d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)(C)C1=CC(=C(C=C1)O)C(C)(C)CC,https://pubchem.ncbi.nlm.nih.gov/compound/8455,PubChem,CCC(C)(C)c1ccc(O)c(C(C)(C)CC)c1,Test,1,2702,training
-"EU_REACH:
-2-Chloro-1-(1-chlorocyclopropyl)ethanone",,120983-72-4,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/9302/7/4/2/?documentUUID=54bc83d5-8e31-4a70-a1c0-0c26cb0fa45e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC1(C(=O)CCl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11062580,PubChem,O=C(CCl)C1(Cl)CC1,Train,1,2702,training
-"JP_CHRIP:
-2-Methyl-5-nitrobenzenesulfonic acid","JP_CHRIP:
-2-methyl-5-nitrobenzenesulfonic acid",121-03-9,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0086e.html,"JP_CHRIP:
-It is reported that it was moderately irritating in a test in which 20 mg of this substance was applied to the rabbit skin for 24 hours (IUCLID (2000), RTECS (1997)), but it was classified in Category 1 from the knowledge that the pH of an aqueous solution (100 g/L) of this substance was less than 1 (IUCLID (2000)).",,JP_CHRIP,1,Cc1ccc(cc1S(=O)(=O)O)[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J10.070F,J-GLOBAL,Cc1ccc([N+](=O)[O-])cc1S(=O)(=O)O,Train,1,2702,training
-"EU_REACH:
-1-ethoxy-2,3-difluorobenzene",,121219-07-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22555/7/4/2/?documentUUID=1ccbfe49-5d7a-476d-82ca-f6177223fe75,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=C(C(=CC=C1)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/2782928,PubChem,CCOc1cccc(F)c1F,Train,1,2702,training
-"AU_HCIS:
-triethylamine
-
-JP_CHRIP:
-Triethylamine
-
-KR_NCIS:
-Triethylamine
-
-NZ_CCID:
-Ethanamine, N,N-diethyl-
-
-US_HSDB:
-TRIETHYLAMINE","AU_HCIS:
-Ethanamine, N,N-diethyl-
-
-JP_CHRIP:
-N,N-Diethylethanamine
-
-KR_NCIS:
-N,N-Diethylethanamine
-
-NZ_CCID:
-(Diethylamino)ethane, TEA, Triethylamine, n,n-Diethylethanamine",121-44-8,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4580
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0118e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/997D38F8-A52C-4958-84D4-2B474B59B18D
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/896","JP_CHRIP:
-In a skin irritation test using rabbits under occlusive application for 3 minutes, 1 hour or 4 hours, it was found to be corrosive (DFGOT Vol.13 (1999)). Therefore, this substance was classified in Category 1.
-
-NZ_CCID:
-Skin Irritation
-R-PHRASE: R 35 Causes severe burns. [IUCLID 2000]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Strongly alkaline and when drop is applied to the rabbits eye, causes severe injury, graded 9 on a scale of 1 to 10 after 24 hr/ Most severe injuries ahve been rated 10. tests of aq soln on rabbit eyes @ pH 10 and pH 11 indicate injuriousness of triethylamine/ is rated principally to degree of alkalinity. Chronic exposure of rabbits to vapours @ concn as low as 50 ppm in air causes multiple erosions of cornea and conjunctiva in 6 weeks.
-REFERENCE SOURCE: [Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986. 944]**PEER REVIEWED** [HSDB]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,CCN(CC)CC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.485F,J-GLOBAL,CCN(CC)CC,Train,1,2702,training
-"EU_REACH:
-4-methanesulfonyl-2-(trifluoromethyl)benzaldehyde",,1215310-75-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27232/7/4/2/?documentUUID=1d540db8-6860-476c-99e4-1d4927980fc6,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CS(=O)(=O)C1=CC(=C(C=C1)C=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/51342018,PubChem,CS(=O)(=O)c1ccc(C=O)c(C(F)(F)F)c1,Train,1,2702,training
-"EU_CLP:
-sulphanilic acid; 4-aminobenzenesulphonic acid",,121-57-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC(=CC=C1N)S(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/8479,PubChem,Nc1ccc(S(=O)(=O)O)cc1,Test,1,2702,training
-"EU_REACH:
-(1r,4r)-N1,N1,N4,N4-tetrakis(2-hydroxyethyl)cyclohexane-1,4-dicarboxamide",,1215841-86-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5440/7/4/2/?documentUUID=37975966-991f-4aa2-9b8c-8b61d1d30bd8,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC(CCC1C(=O)N(CCO)CCO)C(=O)N(CCO)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/58434361,PubChem,O=C(C1CCC(C(=O)N(CCO)CCO)CC1)N(CCO)CCO,Train,1,2702,training
-"NZ_CCID:
-4-Acetamidobenzenesulphonyl chloride","NZ_CCID:
-N-acetylsulfanilyl chloride",121-60-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1ECCEC52-E782-484C-AE66-CBA9069E87F9,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(=O)NC1=CC=C(C=C1)S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/8481,PubChem,CC(=O)Nc1ccc(S(=O)(=O)Cl)cc1,Train,1,2702,training
-"EU_CLP:
-1-allyl-3-chloro-4-fluorobenzene",,121626-73-1,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C=CCC1=CC(=C(C=C1)F)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/2757597,PubChem,C=CCc1ccc(F)c(Cl)c1,Test,1,2702,training
-"EU_REACH:
-9-[(3,3'-di-tert-butyl-2'-{8,10-dioxa-9-phosphatricyclo[9.4.0.0²,⁷]pentadeca-1(11),2(7),3,5,12,14-hexaen-9-yloxy}-5,5'-dimethoxy-[1,1'-biphenyl]-2-yl)oxy]-8,10-dioxa-9-phosphatricyclo[9.4.0.0²,⁷]pentadeca-1(11),2(7),3,5,12,14-hexaene",,121627-17-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12308/7/4/2/?documentUUID=7c029f5e-a96b-45e4-9a4a-3758f6009c89,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1=CC(=CC(=C1OP2OC3=CC=CC=C3C4=CC=CC=C4O2)C5=C(C(=CC(=C5)OC)C(C)(C)C)OP6OC7=CC=CC=C7C8=CC=CC=C8O6)OC,https://pubchem.ncbi.nlm.nih.gov/compound/10865829,PubChem,COc1cc(-c2cc(OC)cc(C(C)(C)C)c2Op2oc3ccccc3c3ccccc3o2)c(Op2oc3ccccc3c3ccccc3o2)c(C(C)(C)C)c1,Train,1,2702,training
-"AU_HCIS:
-Benzenesulfonic acid, 4-dodecyl-",,121-65-3,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4887,,,AU_HCIS,1,CCCCCCCCCCCCC1=CC=C(C=C1)S(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/8485,PubChem,CCCCCCCCCCCCc1ccc(S(=O)(=O)O)cc1,Train,1,2702,training
-"ChemSkin:
-1-Chloro-3-nitrobenzene (3-chloronitrobenzene)",,121-73-3,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,C1=CC(=CC(=C1)Cl)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/8489,PubChem,O=[N+]([O-])c1cccc(Cl)c1,Test,1,2702,training
-"EU_REACH:
-2-chloro-1-methyl-4-nitrobenzene",,121-86-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1542/7/4/2/?documentUUID=efe61ba0-d389-4a51-9bb7-08d4fd5a0b37,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)[N+](=O)[O-])Cl,https://pubchem.ncbi.nlm.nih.gov/compound/8491,PubChem,Cc1ccc([N+](=O)[O-])cc1Cl,Train,1,2702,training
-"JP_CHRIP:
-Butyl (R)-2-[4-(4-cyano-2-fluorophenoxy)phenoxy]propionate; Cyhalofop-butyl",,122008-85-9,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2080e.html,"JP_CHRIP:
-[Rationale for the Classification]
-Based on (1), it was classified in Category 2. The classification was changed because new data were obtained.
-
-[Evidence Data]
-(1) In a skin sensitization test with 3 rabbits, irritation scores at 1/24/48/72 hours were all 1-2, and the reactions remained even after 7 days. Besides, mild erythema was noted in one out of 3 rabbits after 21 days (EPA Pesticide (2002)).
-
-[Reference Data, etc.]
-(2) This substance was non-irritant (EFSA (2015)).",,JP_CHRIP,1,CCCCOC(=O)[C@@H](C)Oc1ccc(Oc2ccc(cc2F)C#N)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J738.981G,J-GLOBAL,CCCCOC(=O)[C@@H](C)Oc1ccc(Oc2ccc(C#N)cc2F)cc1,Train,1,2702,training
-"NZ_CCID:
-4-Nitrobenzoyl chloride",,122-04-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1F70CA0D-4102-4E3F-A3EC-2619F1D31B9D,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1C(=O)Cl)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/8502,PubChem,O=C(Cl)c1ccc([N+](=O)[O-])cc1,Train,1,2702,training
-"EU_REACH:
-O,O-dimethyl O-3-methyl-4-nitrophenyl phosphorothioate
-
-JP_CHRIP:
-O,O-Dimethyl-O-(3-methyl-4-nitrophenyl) thiophosphate [Fenitrothion]","JP_CHRIP:
-Fenitrothion
-O,O'-dimethyl-O-(3-methyl-4-nitrophenyl) monothiophosphate
-O,O'-Dimethyl-O-(3-methyl-4-nitrophenyl)phosphorothioate
-O,O-Dimethyl O-3-methyl-4-nitrophenyl phosphorothioate
-O,O-Dimethyl O-4-nitro-m-tolyl phosphorothioate
-O,O-Dimethyl O-4-nitro-m-tolyl thiophosphate
-O,O-Dimethyl-O-(3-methyl-4-nitrophenyl) thiophosphate
-Phosphorothioic acid, O,O-dimethyl O-(3-methyl-4-nitrophenyl) ester",122-14-5,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27782/7/4/2/?documentUUID=efd959b1-f517-4b3e-b2ee-82f05036fee8
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2076e.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-Based on a report that skin irritation was not observed in a skin irritation test with rabbits (EHC 133 (1992), Risk Assessment Report (Pesticides and Veterinary Medicinal Products) (Food Safety Commission of Japan, 2014)), it was classified as ""Not classified."" The category was revised based on the information obtained in this research.",Provided,"EU_REACH, JP_CHRIP",2,COP(=S)(OC)Oc1ccc(c(C)c1)[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.492I,J-GLOBAL,COP(=S)(OC)Oc1ccc([N+](=O)[O-])c(C)c1,Train,1,2702,training
-"AU_HCIS:
-2-Propanol, 1,1',1''-nitrilotris-
-
-JP_CHRIP:
-1,1',1''-nitrilotripropan-2-ol; triisopropanolamine
-
-NZ_CCID:
-Triisopropanolamine","AU_HCIS:
-1,1',1''-nitrilotripropan-2-ol
-Triisopropanolamine
-1,1',1'-nitrilotripropan-2-ol
-
-JP_CHRIP:
-1,1',1''-Nitrilotripropan-2-ol
-Tri-2-propanolamine
-Triisopropanolamine
-Tris(2-hydroxypropyl)amine
-tris(2-hydroxypropyl)amine [synonym:triisopropanolamine]
-
-NZ_CCID:
-TIPA, Tris(2-hydroxypropyl)amine",122-20-3,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3673
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0181e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/60BF8746-F003-412B-B9A8-308C2B494B72","JP_CHRIP:
-Based on the report that treatment of rabbits with 85% aqueous solution resulted in the development of erythema, edema, and desquamation (BUA Report No. 148 (1993)), the substance was classified into Category 2.
-
-NZ_CCID:
-Skin Irritation
-SPECIES:
-RESULT: Moderate.
-REFERENCE SOURCE: [Hawley, G.G. The Condensed Chemical Dictionary. 9th ed. New York: Van Nostrand Reinhold Co., 1977. 886]**PEER REVIEWED**[HSDB]
-Eye Irritation
-SPECIES: Rabbits
-RESULT: The neat material has caused permanent eye damage in rabbits.
-REFERENCE SOURCE: Authors: BIBRA working group Source: TA:Toxicity profile. The British Industrial Biological Research Association PG:3 p YR:1987 IP: VI: [TOXLINE]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CC(O)CN(CC(C)O)CC(C)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.616A,J-GLOBAL,CC(O)CN(CC(C)O)CC(C)O,Train,1,2702,training
-"EU_REACH:
-3-hydroxy-4-{[2-methoxy-5-(phenylcarbamoyl)phenyl]diazenyl}-N-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-2-naphthamide",,12225-06-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13914/7/4/2/?documentUUID=b3d41585-a0af-42b5-bcd4-723bc1697f3c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COc1ccc(cc1N\N=C2/C(=O)C(=Cc3ccccc23)C(=O)Nc4ccc5NC(=O)Nc5c4)C(=O)Nc6ccccc6,https://cactus.nci.nih.gov/chemical/structure/12225-06-8/smiles,CACTUS,COc1ccc(C(=O)Nc2ccccc2)cc1N/N=C1\C(=O)C(C(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)=Cc2ccccc21,Train,1,2702,training
-"EU_REACH:
-N-(4-chloro-2,5-dimethoxyphenyl)-2-{[2,5-dimethoxy-4-(phenylsulfamoyl)phenyl]diazenyl}-3-oxobutanamide",,12225-18-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11078/7/4/2/?documentUUID=286f124c-4bfa-47eb-b7d5-81bc70834824,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC(=C(C=C1OC)Cl)OC)N=NC2=CC(=C(C=C2OC)S(=O)(=O)NC3=CC=CC=C3)OC,https://pubchem.ncbi.nlm.nih.gov/compound/61559,PubChem,COc1cc(NC(=O)C(N=Nc2cc(OC)c(S(=O)(=O)Nc3ccccc3)cc2OC)C(C)=O)c(OC)cc1Cl,Train,1,2702,training
-"EU_REACH:
-N-(4-acetamidophenyl)-4-[(5-carbamoyl-2-chlorophenyl)diazenyl]-3-hydroxy-2-naphthamide",,12236-64-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10624/7/4/2/?documentUUID=6892ac2e-658d-4d03-a82d-fde7d2bfdedd,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)NC1=CC=C(C=C1)NC(=O)C2=CC3=CC=CC=C3C(=C2O)N=NC4=C(C=CC(=C4)C(=O)N)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/82995,PubChem,CC(=O)Nc1ccc(NC(=O)c2cc3ccccc3c(N=Nc3cc(C(N)=O)ccc3Cl)c2O)cc1,Train,1,2702,training
-"AU_HCIS:
-Heptanal, 2-(phenylmethylene)-
-
-JP_CHRIP:
-Amylcinnamaldehyde","JP_CHRIP:
-alpha-pentylcinnamaldehyde",122-40-7,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5439
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0089e.html","JP_CHRIP:
-It was classified in Category 2 because it is described that it is a severe skin irritant in humans (HSDB (2012)), and there is a report on List 3 knowledge that it was severely irritating in a Draize test in which 100 mg was applied to the rabbit skin for 24 hours (RTECS (2011)).",,"AU_HCIS, JP_CHRIP",2,CCCCCC(=Cc1ccccc1)C=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J9.183I,J-GLOBAL,CCCCCC(C=O)=Cc1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-Triethoxymethane","JP_CHRIP:
-Ethyl orthoformate",122-51-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0105e.html,"JP_CHRIP:
-Based on a result of ""not irritating"" in a rabbit test (OECD TG404 (GLP)) (IUCLID (2000)), the substance was classified as ""Not classified"".",Provided,JP_CHRIP,1,CCOC(OCC)OCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.533F,J-GLOBAL,CCOC(OCC)OCC,Train,1,2702,training
-"JP_CHRIP:
-Triethyl phosphite","JP_CHRIP:
-Phosphorous acid, triethyl ester",122-52-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0005e.html,"JP_CHRIP:
-Based on results of ""slightly irritating"" (PDII: 1.4) in a rabbit test (OECD TG404) (SIDS (2003)) and ""mildly irritating"" (PDII: 1.7) in another rabbit Draize test (SIDS (2003)), the substance was classified as ""Not classified"" in JIS Classification (correspond to Category 3 in GHS classification).",Provided,JP_CHRIP,1,CCOP(OCC)OCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.007I,J-GLOBAL,CCOP(OCC)OCC,Train,1,2702,training
-"NZ_CCID:
-Phenoxyacetic acid",,122-59-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4BBFC051-AD4B-4B9C-9400-46EFE383D1EE,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)OCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/19188,PubChem,O=C(O)COc1ccccc1,Train,1,2702,training
-"AU_HCIS:
-Oxirane, (phenoxymethyl)-
-
-JP_CHRIP:
-2,3-Epoxypropyl phenyl ether [Phenyl glycidyl ether]
-
-KR_NCIS:
-(Phenoxymethyl)oxirane; 2,3-Epoxypropyl phenyl ether
-
-NZ_CCID:
-Phenyl glycidyl ether","AU_HCIS:
-phenyl glycidyl ether
-2,3-epoxypropyl phenyl ether
-1,2-epoxy-3- phenoxypropane
-
-JP_CHRIP:
-2,3-Epoxypropyl phenyl ether
-1,2-Epoxy-3-phenoxypropane
-2,3-Epoxypropyl phenyl ether
-PGE
-Phenoxy methyloxirane
-Phenyl glycidyl ether
-
-NZ_CCID:
-(Phenoxymethyl)oxirane, 1,2-Epoxy-3-phenoxypropane, 1-Phenoxy-2,3-epoxypropane, 2,3-Epoxy-1-phenoxypropane, 2,3-Epoxypropyl phenyl ether, 2,3-Epoxypropylphenyl ether, 3-Phenoxy-1,2-epoxypropane, 3-Phenoxy-1,2-propylene oxide, 3-Phenyloxy-1,2-epoxypropane, Glycidol phenyl ether, Glycidyl phenyl ether, Oxirane, (phenoxymethyl)-, Phenoxypropene oxide, Phenyl 2,3-epoxypropyl ether, Phenylglycidyl ether, Propane, 1,2-epoxy-3-phenoxy-",122-60-1,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3326
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2043e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/72DB0515-1FE8-4E02-AA29-119B9151D771","JP_CHRIP:
-Based on a description of skin irritation in humans (Environmental Risk Assessment for Chemical Substances Vol.3, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2004), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), and a report that slight irritation was shown in a skin irritation test with rabbits (ACGIH (7th, 2014)), it was classified in Category 2. Besides, this substance was classified as ""Skin Irrit. 2"" in the EU CLP classification (ECHA CL Inventory (Access on June 2017)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [N-CLASS]
-Eye Irritation
-SPECIES:
-RESULT: Irritant.
-REFERENCE SOURCE: [Sax, N.I. and R.J. Lewis, Sr. (eds.). Hawleys Condensed Chemical Dictionary. 11th ed. New York: Van Nostrand Reinhold Co., 1987.903]**PEER REVIEWED** [HSDB]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID",4,C(Oc1ccccc1)C1CO1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.258A,J-GLOBAL,c1ccc(OCC2CO2)cc1,Train,1,2702,training
-"EU_REACH:
-(4E)-4-methyl-5-(4-methylphenyl)pent-4-enal",,1226911-69-8,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21521/7/4/2/?documentUUID=ca997ad8-7328-4960-a663-b75c56a8a079,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)/C=C(\C)/CCC=O,https://pubchem.ncbi.nlm.nih.gov/compound/71465644,PubChem,C/C(=C\c1ccc(C)cc1)CCC=O,Train,1,2702,training
-"EU_REACH:
-4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyl methacrylate",,1228350-17-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18171/7/4/2/?documentUUID=ba69bd97-7c66-452a-888c-5fbb792423ca,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OCCCC(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/19098704,PubChem,C=C(C)C(=O)OCCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train,1,2702,training
-"EU_REACH:
-3-octyl-1-[4-({4-[(octylcarbamoyl)amino]phenyl}methyl)phenyl]urea",,122886-55-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16583/7/4/2/?documentUUID=a47fcfce-f39a-4f64-a226-911cb22f8936,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCNC(=O)NC1=CC=C(C=C1)CC2=CC=C(C=C2)NC(=O)NCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/14299396,PubChem,CCCCCCCCNC(=O)Nc1ccc(Cc2ccc(NC(=O)NCCCCCCCC)cc2)cc1,Train,1,2702,training
-"US_HSDB:
-3-Phenylpropanol",,122-97-4,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8266,,,US_HSDB,1,C1=CC=C(C=C1)CCCO,https://pubchem.ncbi.nlm.nih.gov/compound/31234,PubChem,OCCCc1ccccc1,Train,1,2702,training
-"EU_REACH:
-3-morpholin-4-ylpropan-1-amine
-
-NZ_CCID:
-4-Morpholinepropanamine","NZ_CCID:
-(3-Aminopropyl)morpholine, 1-Amino-3-morpholinopropane, 3-Morpholinopropanamine, 3-Morpholinopropylamine, 4-(3-Aminopropyl)morpholine, Morpholine, 4-(3-aminopropyl)- (8CI), Morpholine, 4-aminopropyl-, Morpholine, N-aminopropyl-, N-(3-Aminopropyl)morpholine, N-Aminopropylmorpholine, gamma-Morpholinopropylamine",123-00-2,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24742/7/4/2/?documentUUID=6d8b456b-10a7-4a35-9942-a0fe7f5ef67a
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4EAC4513-4CEC-4A78-9CB8-F5B140AB94F3","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Extremely irritating/ Corrosive
-REFERENCE SOURCE: (http://www.huntsman.com/performance_chemicals/Media/APM.pdf)
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Extremely irritating/ Corrosive
-REFERENCE SOURCE: (http://www.huntsman.com/performance_chemicals/Media/APM.pdf)",Provided,"EU_REACH, NZ_CCID",2,C1COCCN1CCCN,https://pubchem.ncbi.nlm.nih.gov/compound/61055,PubChem,NCCCN1CCOCC1,Train,1,2702,training
-"NZ_CCID:
-4-Hydroxybenzaldehyde",,123-08-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BDE7A986-274B-4083-8013-E9CEC55A308E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1C=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/126,PubChem,O=Cc1ccc(O)cc1,Train,1,2702,training
-"EU_REACH:
-4-[(3-carboxypropanoyl)peroxy]-4-oxobutanoic acid",,123-23-9,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24749/7/4/2/?documentUUID=84c9b78d-2fa5-49a9-95c5-086fa74344d0,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CC(=O)OOC(=O)CCC(=O)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/31248,PubChem,O=C(O)CCC(=O)OOC(=O)CCC(=O)O,Train,1,2702,training
-"EU_REACH:
-1,4-diethyl butanedioate",,123-25-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27981/7/4/2/?documentUUID=c266f723-64cd-466a-b644-0e18b70e9dfe,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CCC(=O)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/31249,PubChem,CCOC(=O)CCC(=O)OCC,Train,1,2702,training
-"JP_CHRIP:
-7-Methyl-3-methylene-1,6-octadiene
-
-NZ_CCID:
-1,6-Octadiene, 7-methyl-3-methylene-","JP_CHRIP:
-7-methyl-3-methylene-1,6-octadiene
-7-methyl-3-methyleneocta-1,6-diene
-
-NZ_CCID:
-Myrcene",123-35-3,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2032e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5BEFB20B-2550-4BF4-B8D5-06E50C7FD1D1","JP_CHRIP:
-[Rationale for the Classification]
-It was classified in Category 2 from (1) - (3).
-
-[Evidence Data]
-(1) This substance is an irritant in humans, and exposure to this substance induces dermatitis and conjunctivitis (NTP TR557 (2010)).
-(2) This substance is a moderate skin and eye irritant (HSDB (Access on May 2020)).
-(3) In an in-vitro skin irritation test using the human epidermis model (EPISKIN) according to ECVAM protocol version 1.8 (2009), it was judged as an irritant (REACH registration dossier (Access on June 2020)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Moderately irritating
-REFERENCE SOURCE: BUSH BOAKE ALLEN LTD LONDON (2) Opdyke, Fd. & Cosmet. Toxicol. 1976, 14, 615. [IUCLID 2000]
-REMARKS: EC Classification: Not irritating.
-
-Eye Irritation
-SPECIES:
-RESULT: Moderate irritant
-REFERENCE SOURCE: Lewis, R.J. Saxs Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996. 2365 **PEER REVIEWED** [HSDB]",,"JP_CHRIP, NZ_CCID",2,CC(=CCCC(=C)C=C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.010I,J-GLOBAL,C=CC(=C)CCC=C(C)C,Train,1,2702,training
-"JP_CHRIP:
-Propionaldehyde","JP_CHRIP:
-Methylacetaldehyde
-Propionaldehyde
-Propionic aldehyde
-Propyl aldehyde",123-38-6,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0031e.html,"JP_CHRIP:
-In 2 skin irritation tests using rabbits (OECD TG404, GLP compliance or EPA TSCA Guideline, GLP compliance) in application of 0.5 mL undiluted this substance, in the former test, slight erythema was observed but resolved within 24 hours (BUA 195 (1996)), and in the latter test, moderate to severe irritation with necrosis was found and persisted after 14 days in 4/6 animals (SIDS (2007), ACGIH (7th, 2002)). Moreover, it is reported that in other skin irritation tests using rabbits, marked erythema was observed in 1/5 animal after application of 0.01 mL undiluted this substance (SIDS (2007), ACGIH (7th, 2002)), and it is reported that slight to severe irritation was found after 24-hour occlusive application of undiluted this substance, and PII (primary irritation index) was 3.9 (ACGIH (7th, 2002)). Furthermore, it is reported that in an irritation test using guinea pigs, severe irritation was observed, but there is no description on recovery (SIDS (2007), ACGIH (7th, 2002)). Moreover, it is reported that in a report in humans, 12 Asian volunteers were patch tested with this substance for 5 minutes, and severe erythema in 5 persons and weak erythema in 7 were found (ACGIH (7th, 2002)). From the above results, the substance was judged to be Category 2. Besides, it is classified in ""Skin Irrit. 2 H315"" in EU CLP classification (ECHA CL Inventory (Access on June 2015)).",Provided,JP_CHRIP,1,CCC=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.497J,J-GLOBAL,CCC=O,Train,1,2702,training
-"JP_CHRIP:
-Diacetone alcohol","JP_CHRIP:
-2-Pentanone, 4-hydroxy-4-methyl-
-4-Hydroxy-2-keto-4-methylpentane
-4-Hydroxy-4-methyl-2-pentanone
-4-hydroxy-4-methylpentan-2-one",123-42-2,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2031e.html,"JP_CHRIP:
-Based on results of ""mild irritation"" to ""moderately irritating"" in rabbit tests (PATTY (5th, 2001), SIDS (2000)), the substance was classified into Category 2.",,JP_CHRIP,1,CC(=O)CC(C)(C)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.540I,J-GLOBAL,CC(=O)CC(C)(C)O,Train,1,2702,training
-"EU_REACH:
-1-Ethoxy-2,3-difluoro-4-[trans-4-(trans-4-propylcyclohexyl)-cyclohexyl]-benzene",,123560-48-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24097/7/4/2/?documentUUID=d78f8475-f561-4868-b086-04179e005276,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2CCC(CC2)C3=C(C(=C(C=C3)OCC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/11417199,PubChem,CCCC1CCC(C2CCC(c3ccc(OCC)c(F)c3F)CC2)CC1,Train,1,2702,training
-"EU_REACH:
-pyrrolidine-2,5-dione",,123-56-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30168/7/4/2/?documentUUID=c07eafc2-8204-49b3-85e7-7ef86ff93357,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC(=O)NC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/11439,PubChem,O=C1CCC(=O)N1,Train,1,2702,training
-"JP_CHRIP:
-propionic anhydride
-
-NZ_CCID:
-Propionic anhydride","JP_CHRIP:
-Methylacetic anhydride
-Propanoic acid anhydride
-Propanoic anhydride
-propionic anhydride",123-62-6,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0184e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F56DF2CD-F535-4A20-A1B3-6D5965DDA08A","JP_CHRIP:
-This substance is reported to cause skin corrosion or burns in humans (HSDB (2005), SITTIG vol. 2). In addition, it is rated as C; R34 in the EU classification (EU-Annex 1 (accessed in November 2008)). Thus, the substance was classified into Category 1. As additional background information, propionic anhydride, in contact with water, produces propionic acid (ICSC (J) (2005)), which is skin corrosive (ICSC (J) (2005)). (Regarding propionic acid, see NITE ID926.)
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CCC(=O)OC(=O)CC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.542E,J-GLOBAL,CCC(=O)OC(=O)CC,Train,1,2702,training
-"JP_CHRIP:
-butyraldehyde","JP_CHRIP:
-Butyraldehyde
-Butanal
-Butyl aldehyde
-n-butyraldehyde",123-72-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0106e.html,"JP_CHRIP:
-Since it is documented that in two tests using rabbits (both tests are in compliant with OECD TG 404, GLP), the substance was either not irritating or slightly irritating (IUCLID (2000)), it was classified into the ""Not classified"" category using JIS classification criteria (Category 3 in UN classification).",Provided,JP_CHRIP,1,CCCC=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.501A,J-GLOBAL,CCCC=O,Train,1,2702,training
-"AU_HCIS:
-(E)-2-butenal
-
-KR_NCIS:
-Crotonaldehyde
-
-NZ_CCID:
-Crotonaldehyde
-
-US_HSDB:
-(E)-Crotonaldehyde","AU_HCIS:
-(E)-crotonaldehyde
-2-Butenal, (E)-
-trans-2-butenal
-trans-crotonaldehyde
-
-KR_NCIS:
-(2E)-2-Butenal; (E)-2-Butenal; (E)-But-2-enal; 2-Butenal, (2E)-; 2-Butenal, (E)-; beta-Methylacrolein; Crotenaldehyde; trans-2-Butenal; trans-Crotonaldehyde
-
-NZ_CCID:
-(E)-Crotonaldehyde",123-73-9,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=688
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/78F4510A-6FE5-424B-A7B9-EA3AFD8A24C7
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/2871","NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]
-Eye Irritation
-R PHRASE: R 41 [ECB]",,"AU_HCIS, KR_NCIS, NZ_CCID, US_HSDB",4,C/C=C/C=O,https://pubchem.ncbi.nlm.nih.gov/compound/447466,PubChem,C/C=C/C=O,Train,1,2702,training
-"JP_CHRIP:
-Pyrrolidine
-
-KR_NCIS:
-Pyrrolidine
-
-NZ_CCID:
-Pyrrolidine","JP_CHRIP:
-Azacyclopentane
-Pyrrole, tetrahydro
-
-NZ_CCID:
-Tetrahydropyrrole",123-75-1,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0074e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F6002A7A-04AB-47FD-A266-AF872A32B1F5","JP_CHRIP:
-Based on a result of ""a severe skin irritant"" in a skin primary irritation test with rabbits (PATTY (5th, 2001)), a result that the tails of mice dipped into undiluted test substance showed first signs of necrosis after 54 seconds and then it is corrosive to the skin and data of pH 12.9 (100 g/L, 20 degC) (GESTIS (access on Aug. 2009)), the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-SPECIES:
-RESULT: Corrosive.
-REFERENCE SOURCE: KHB/PD
-Eye Irritation
-SPECIES:
-RESULT: Corrosive
-REFERENCE SOURCE:",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,C1CCNC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.931I,J-GLOBAL,C1CCNC1,Train,1,2702,training
-"NZ_CCID:
-Levulinic acid",,123-76-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E7430ADA-CED9-4E3D-837F-CFA015C15A7F,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(=O)CCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/11579,PubChem,CC(=O)CCC(=O)O,Train,1,2702,training
-"JP_CHRIP:
-1,4-Dioxane","JP_CHRIP:
-1,4-Diethylene dioxide
-1,4-Diethyleneoxide",123-91-1,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2090e.html,"JP_CHRIP:
-Based on results of ""moderately irritating"" in a rabbit skin irritation test (open Draize test) (Hazard Assessment Report (CERI, NITE) (2006)) and ""slightly irritating"" in a rabbit, rat and mouse skin irritation tests (EU-RAR No. 21 (2002)), the substance was classified into Category 2.",,JP_CHRIP,1,C1COCCO1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.502J,J-GLOBAL,C1COCCO1,Train,1,2702,training
-"JP_CHRIP:
-Acetic acid isopentyl (Isoamyl acetate)","JP_CHRIP:
-1-Butanol, 3-methyl-, acetate
-3-Methylbutyl acetate
-Isopentyl acetate; Isoamyl acetate",123-92-2,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2120e.html,"JP_CHRIP:
-Since there is a description that all amyl acetate compounds including this substance were irritating to the skin (ACGIH (7th, 2001)), it was classified in Category 2. Besides, there is a report that after repeated occlusive application of a 20% solution of this substance to 197 human subjects, no irritation was observed (DFGOT vol. 11 (1996)). In addition, there is a report that slight irritation was observed after application of an isomer mixture containing this substance to the ears of rabbits, and there is a description that after a 4-hour non-occlusive application of 0.5 mL of an isomer mixture to rabbits, moderate erythema and slight edema were observed, and slight desquamation was observed 7 days after application (DFGOT vol. 11 (1996)). Information in ACGIH (7th, 2001) was added and the category was changed.",,JP_CHRIP,1,CC(C)CCOC(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.012E,J-GLOBAL,CC(=O)OCCC(C)C,Train,1,2702,training
-"NZ_CCID:
-2,2'-Thiodiacetic acid","NZ_CCID:
-thiodiglycolic acid",123-93-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6941147A-FD23-46EE-AD93-86590419B342,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(C(=O)O)SCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/31277,PubChem,O=C(O)CSCC(=O)O,Train,1,2702,training
-"EU_REACH:
-1-(4-chlorophenyl)-2-cyclopropylpropan-1-ol",,123989-28-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19446/7/4/2/?documentUUID=9fe4d492-314a-4b3c-b563-52fa4a24e2ed,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C1CC1)C(C2=CC=C(C=C2)Cl)O,https://pubchem.ncbi.nlm.nih.gov/compound/19078385,PubChem,CC(C1CC1)C(O)c1ccc(Cl)cc1,Test,1,2702,training
-"ChemSkin:
-Octanoic acid (caprylic acid)
-
-EU_CLP:
-octanoic acid",,124-07-2,Cat 1,"ChemSkin: https://doi.org/10.3390/toxics9110314
-EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,Provided,"ChemSkin, EU_CLP",2,CCCCCCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/379,PubChem,CCCCCCCC(=O)O,Test,1,2702,training
-"JP_CHRIP:
-Hexamethylenediamine
-
-NZ_CCID:
-1,6-Hexanediamine","JP_CHRIP:
-1,6-Diaminohexane
-1,6-Hexanediamine
-Hexamethylenediamine
-Hexane-1,6-diamine
-HMD(A)
-
-NZ_CCID:
-1,6-Diamino-n-hexane, 1,6-Diaminohexane, 1,6-Hexamethylenediamine, 1,6-Hexylenediamine, Hexamethylene diamine, Hexamethylenediamine",124-09-4,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-2015e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F6435420-3F0B-4A95-8599-0022404C4DDB","JP_CHRIP:
-Pain reactions were observed within one minute after application of the test substance containing 85% of this substance to the skin of three rabbits, and erythema with small vesicles was seen immediately after the removal of the patch (after 15 minutes) (SIDS (Access on Oct. 2011)). Furthermore, as a result of the 24-hour application of the powders of the test substance to three rabbits, the irritation score was 8 for all three animals at all observation points (maximum 8), and it was judged as corrosive (USEPA/HPV (2003), corresponding to List 1). From the above, it was classified in Category 1. Besides, it is described that the pH of this substance (100 g/L an aqueous solution) was 12.4 (GESTIS (Access on Sept. 2011)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Corrosive
-REFERENCE SOURCE: BASF AG Ludwigshafen.
-(53) TSCATS, OTS0520783, Doc. I. D. 86-890001277, 07-24-89, Hoechst Celanese Corporationy (54) TSCATS, OTS0534489, Doc. I. D. 86-920000433, 12-03-91, Hoechst Celanese Corporation [IUCLID 2000]
-R PHRASE: R 34 [IUCLID 2000]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Severe opacity of cornea, hemorrhages on conjunctiva and iris
-REFERENCE SOURCE: BASF AG Ludwigshafen. (129) TSCATS, OTS0555377, Doc. I. D. 88-920009060, 09-10-92, E.I. Dupont de Nemours and Co [IUCLID 2000]",,"JP_CHRIP, NZ_CCID",2,NCCCCCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J10.055B,J-GLOBAL,NCCCCCCN,Train,1,2702,training
-"NZ_CCID:
-Octanal
-
-US_HSDB:
-Octylaldehyde","NZ_CCID:
-octyl aldehyde",124-13-0,Cat 2,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F9FBEFCB-FA00-4952-ABF3-F65D7D6B9661
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/5147","NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,"NZ_CCID, US_HSDB",2,CCCCCCCC=O,https://pubchem.ncbi.nlm.nih.gov/compound/454,PubChem,CCCCCCCC=O,Train,1,2702,training
-"JP_CHRIP:
-Decane",,124-18-5,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0078e.html,"JP_CHRIP:
-Based on a result of ""slightly irritating"" in a rabbit test (OECD TG404 (GLP)) (IUCLID (2000)) and ""slightly irritating"" in another rabbit test (Directive 84/449/EEC, B.4) where the maximum mean score was 1.5 for erythema at 72-hour after application (IUCLID (2000)), the substance was classified as ""Not classified"" in JIS Classification (correspond to Category 3 in GHS classification). As relevant information, there is a report of ""no irritation "" in tests with human subjects where a 30% solution was applied to skin for 24-hour (HSDB (2003)).",Provided,JP_CHRIP,1,CCCCCCCCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.505D,J-GLOBAL,CCCCCCCCCC,Train,1,2702,training
-"JP_CHRIP:
-1-Nonanal
-
-NZ_CCID:
-Nonanal
-
-US_HSDB:
-NONANAL","NZ_CCID:
-nonyl aldehyde",124-19-6,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0004e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/37252634-2278-4F0D-8A8A-CE6F04E09F6E
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/7229","JP_CHRIP:
-From a primary irritation index (PII) of 3.46/8 in a test using 4 rabbits (OECD TG404, GLP compliance) in which erythema and edema were observed in all animals throughout the 7-day observation period after administration (ECETOCTR63 (1995)), it was classified in Category 2.
-Besides, severe edema and burns were observed at application sites at a dose of 5000 mg/kg in an acute dermal toxicity test in rabbits. (HSDB (2005))
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",Provided,"JP_CHRIP, NZ_CCID, US_HSDB",3,CCCCCCCCC=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.547F,J-GLOBAL,CCCCCCCCC=O,Train,1,2702,training
-"NZ_CCID:
-Spermidine","NZ_CCID:
-1,4-Butanediamine, N-(3-aminopropyl)-",124-20-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/78FC3E9A-504D-4135-882F-9B11A27528A6,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C(CCNCCCN)CN,https://pubchem.ncbi.nlm.nih.gov/compound/1102,PubChem,NCCCCNCCCN,Train,1,2702,training
-"AU_HCIS:
-1-Dodecanamine
-
-NZ_CCID:
-Dodecylamine",,124-22-1,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4989
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/ACE84350-B2BD-4C79-8E03-49C02023B0CA","NZ_CCID:
-Skin Irritation
-R PHRASE: R 35 [Company Data]
-Eye Irritation
-R PHRASE: R 35 [Company Data]",,"AU_HCIS, NZ_CCID",2,CCCCCCCCCCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/13583,PubChem,CCCCCCCCCCCCN,Train,1,2702,training
-"JP_CHRIP:
-Methanesulfonyl chloride
-
-KR_NCIS:
-Methanesulfonyl chloride
-
-NZ_CCID:
-Methanesulphonyl chloride","JP_CHRIP:
-Mesyl chloride
-Methanesulfonic acid chloride
-Methylsulfonyl chloride",124-63-0,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0192e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C421ED1A-ED97-4CDF-BB8F-5F1D253D1A2C","JP_CHRIP:
-Based on results of corrosive in a mouse skin irritation test (anesthetized tail method) (PATTY (5th, 2001), IUCLID (2000)), the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,CS(=O)(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.507K,J-GLOBAL,CS(=O)(=O)Cl,Train,1,2702,training
-"JP_CHRIP:
-2-amino-2-methylpropanol
-
-NZ_CCID:
-2-Amino-2-methyl-1-propanol","JP_CHRIP:
-2-Amino-2-methyl-1-propanol
-2-Amino-2-methylpropanol
-2-Aminodimethylethanol
-2-Aminoisobutanol
-
-NZ_CCID:
-1,1-Dimethyl-2-hydroxyethylamine, 1-Propanol, 2-amino-2-methyl-, 2-Amino-1-hydroxy-2-methylpropane, 2-Amino-2,2-dimethylethanol, 2-Amino-2-methylpropanol, 2-Hydroxymethyl-2-propylamine, Aminomethylpropanol",124-68-5,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0187e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8F0E9FD2-6A11-4B40-B695-4551D248A5AE","JP_CHRIP:
-The substance is reported to be a severe irritant (DFGOT vol. 9 (1998)). It is unknown if irritation is reversible and is rated as R38 by the EU.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Highly irritating
-REFERENCE SOURCE: ANGUS Chemie GmbH Ibbenburen. [IUCLID]
-REMARK: EC Classification: Irritating
-Eye Irritation
-R-PHRASE: R36/38. (IUCLID)",,"JP_CHRIP, NZ_CCID",2,CC(C)(N)CO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J38.382A,J-GLOBAL,CC(C)(N)CO,Train,1,2702,training
-"KR_NCIS:
-Dichloroethenylmethylsilane
-
-NZ_CCID:
-Dichloromethylvinylsilane","KR_NCIS:
-Silane, dichloroethenylmethyl-",124-70-9,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/44F35E4F-D870-4604-8EEF-F4AC49BCA2DB","NZ_CCID:
-Skin Irritation
-UN # 2985 UN CLASS: 8 PG II
-Eye Irritation
-R PHRASE: R 35 [Company Data]
-UN # 2985 UN CLASS: 8 PG II",,"KR_NCIS, NZ_CCID",2,C[Si](C=C)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/31299,PubChem,C=C[Si](C)(Cl)Cl,Train,1,2702,training
-"EU_CLP:
-4-(3,4-dichlorophenylazo)-2,6-di-sec-butyl-phenol",,124719-26-2,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCC(C)C1=CC(=CC(=C1O)C(C)CC)N=NC2=CC(=C(C=C2)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/136029256,PubChem,CCC(C)c1cc(N=Nc2ccc(Cl)c(Cl)c2)cc(C(C)CC)c1O,Test,1,2702,training
-"EU_REACH:
-1-ethoxy-2,3-difluoro-4-{4-[(1s,4r)-4-propylcyclohexyl]cyclohex-1-en-1-yl}benzene",,124728-62-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/28115/7/4/2/?documentUUID=d9de185c-dc76-4288-9053-eea823683a25,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2CCC(=CC2)C3=C(C(=C(C=C3)OCC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/11462604,PubChem,CCCC1CCC(C2CC=C(c3ccc(OCC)c(F)c3F)CC2)CC1,Train,1,2702,training
-"EU_REACH:
-1-ethoxy-2,3-difluoro-4-[trans-4-(trans-4-pentylcyclohexyl)-cyclohexyl-benzene",,124728-81-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21421/7/4/2/?documentUUID=de581aad-b394-443c-90ed-a478f6e17bb1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCC1CCC(CC1)C2CCC(CC2)C3=C(C(=C(C=C3)OCC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/22184033,PubChem,CCCCCC1CCC(C2CCC(c3ccc(OCC)c(F)c3F)CC2)CC1,Train,1,2702,training
-"EU_REACH:
-methyl 3-(chloromethyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylate",,1247712-63-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17001/7/4/2/?documentUUID=18573f79-4aba-4ba3-85fe-2755da42eaf6,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=CC(=NN1C2=C(C=CC=N2)Cl)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/49850068,PubChem,COC(=O)c1cc(CCl)nn1-c1ncccc1Cl,Train,1,2702,training
-"EU_REACH:
-2-methyl-4-(4-{[6-(prop-2-enoyloxy)hexyl]oxy}benzoyloxy)phenyl 4-{[6-(prop-2-enoyloxy)hexyl]oxy}benzoate",,125248-71-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24921/7/4/2/?documentUUID=c888a066-b4bf-4edd-8645-38c4f1e624a6,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=CC(=C1)OC(=O)C2=CC=C(C=C2)OCCCCCCOC(=O)C=C)OC(=O)C3=CC=C(C=C3)OCCCCCCOC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/21183256,PubChem,C=CC(=O)OCCCCCCOc1ccc(C(=O)Oc2ccc(OC(=O)c3ccc(OCCCCCCOC(=O)C=C)cc3)c(C)c2)cc1,Train,1,2702,training
-"EU_REACH:
-propan-2-yl 3-cyclopentyl-1-methyl-1H-indole-6-carboxylate",,1253789-90-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5917/7/4/2/?documentUUID=aca17551-1744-4edc-b31b-7f6c39810c6b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)OC(=O)C1=CC2=C(C=C1)C(=CN2C)C3CCCC3,https://pubchem.ncbi.nlm.nih.gov/compound/66835544,PubChem,CC(C)OC(=O)c1ccc2c(C3CCCC3)cn(C)c2c1,Train,1,2702,training
-"EU_REACH:
-propan-2-yl 2-bromo-3-cyclopentyl-1-methyl-1H-indole-6-carboxylate",,1253791-42-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5718/7/4/2/?documentUUID=5cd055a9-4eb1-4578-bc02-8e352ef45e20,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)OC(=O)C1=CC2=C(C=C1)C(=C(N2C)Br)C3CCCC3,https://pubchem.ncbi.nlm.nih.gov/compound/66835853,PubChem,CC(C)OC(=O)c1ccc2c(C3CCCC3)c(Br)n(C)c2c1,Train,1,2702,training
-"EU_CLP:
-18-methylnonadecyl 2,2-dimethylpropanoate",,125496-22-2,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C)CCCCCCCCCCCCCCCCCOC(=O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/178374,PubChem,CC(C)CCCCCCCCCCCCCCCCCOC(=O)C(C)(C)C,Test,1,2702,training
-"EU_REACH:
-trans-2-[4'-[difluoro(3,4,5-trifluorophenoxy)methyl]-2,3',5'-trifluoro[1,1'-biphenyl]-4-yl]-5-butyl-1,3-dioxane",,1256753-06-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23992/7/4/2/?documentUUID=565bd2b1-61c6-4a41-8d2f-56e1ff9ca23f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC1COC(OC1)C2=CC(=C(C=C2)C3=CC(=C(C(=C3)F)C(OC4=CC(=C(C(=C4)F)F)F)(F)F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/58362062,PubChem,CCCCC1COC(c2ccc(-c3cc(F)c(C(F)(F)Oc4cc(F)c(F)c(F)c4)c(F)c3)c(F)c2)OC1,Train,1,2702,training
-"EU_REACH:
-1-methoxy-1-[(2-methylbutan-2-yl)peroxy]cyclohexane",,125768-93-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20436/7/4/2/?documentUUID=bda83525-c124-42d8-951e-0410841be1bc,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)(C)OOC1(CCCCC1)OC,https://pubchem.ncbi.nlm.nih.gov/compound/14573036,PubChem,CCC(C)(C)OOC1(OC)CCCCC1,Train,1,2702,training
-"EU_REACH:
-2-Isobutyryl-3,N-diphenylacrylamide",,125971-57-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/4803/7/4/2/?documentUUID=43c44a3a-c178-4bff-b477-2dbf0d9487c5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C(=O)C(=CC1=CC=CC=C1)C(=O)NC2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/53394866,PubChem,CC(C)C(=O)C(=Cc1ccccc1)C(=O)Nc1ccccc1,Train,1,2702,training
-"AU_HCIS:
-Phosphoric acid, tributyl ester
-
-JP_CHRIP:
-Tri-n-butyl phosphate
-
-US_HSDB:
-TRIBUTYL PHOSPHATE","AU_HCIS:
-Tributyl phosphate
-
-JP_CHRIP:
-Phosphoric acid, tributyl ester
-Tri-n-butyl phosphate",126-73-8,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3529
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2083e.html
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1678","JP_CHRIP:
-[Rationale for the Classification]
-Based on (1)-(5), it was classified in Category 2.
-
-[Evidence Data]
-(1) In a skin irritation test with rabbits according to OECD TG404, slight irritation was observed (DFGOT vol.17 (2002), Hazard Assessment Report (CERI, NITE, 2007)).
-(2) By application of this substance (0.5 mL) to the skin of rabbits for 4 and 24 hours, mild irritation was observed (ATSDR (2012)).
-(3) In skin irritation tests with rabbits by application of this substance for 4 hours, slight or marked effects were observed (DFGOT vol.17 (2002)).
-(4) Application of this substance (0,01 mL) to the skin of rabbits showed irritation, and application of this substance (500 mg) to the intact or abraded skin of rabbits produced severe irritation (ACGIH (7th, 2001), EHC 112 (1991), Hazard Assessment Report (CERI, NITE, 2007)).
-(5) This substance had irritative effects on the respiratory organs, skin and eyes (DFGOT vol.17 (2002), PATTY (6th, 2012), GESTIS (Access on September 2019)).
-
-[Reference Data, etc.]
-(6) No irritative effects were found in a skin irritation test by application of this substance to rabbits for 24 hours (DFGOT vol.17 (2002)).
-(7) The skin irritation caused by this substance might be as serious as that caused by morpholine (Category 1) (EHC 112 (1991)).
-(8) It was classified as ""Skin Irrit. 2 (H315)"" by the EU CLP classification (EU CLP classification (Access on September 2019)).",Provided,"AU_HCIS, JP_CHRIP, US_HSDB",3,CCCCOP(=O)(OCCCC)OCCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.623D,J-GLOBAL,CCCCOP(=O)(OCCCC)OCCCC,Train,1,2702,training
-"EU_REACH:
-2,4,7,9-tetramethyldec-5-yne-4,7-diol",,126-86-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14379/7/4/2/?documentUUID=8469e4bb-f4da-4b6d-b017-2ec48c67afec,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CC(C)(C#CC(C)(CC(C)C)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/31362,PubChem,CC(C)CC(C)(O)C#CC(C)(O)CC(C)C,Test,1,2702,training
-"AU_HCIS:
-1,6-Octadien-3-ol, 3,7-dimethyl-, (S)-",,126-90-9,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5348,,,AU_HCIS,1,CC(=CCC[C@@](C)(C=C)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/67179,PubChem,C=C[C@@](C)(O)CCC=C(C)C,Train,1,2702,training
-"EU_REACH:
-N'-(2-Cyano-5-methoxy-4-nitrophenyl)-N,N-dimethylimidoformamide",,1269400-04-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/34043/7/4/2/?documentUUID=4c0537ee-6ee0-4812-b7c6-4861c2b5e9f8,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C)C=NC1=CC(=C(C=C1C#N)[N+](=O)[O-])OC,https://pubchem.ncbi.nlm.nih.gov/compound/53301992,PubChem,COc1cc(N=CN(C)C)c(C#N)cc1[N+](=O)[O-],Train,1,2702,training
-"JP_CHRIP:
-2-Chloro-1,3-butadiene
-
-NZ_CCID:
-1,3-Butadiene, 2-chloro-","JP_CHRIP:
-2-Chloro-1,3-butadiene
-2-Chlorobuta-1,3-diene
-2-Chlorobutadiene
-beta-Chloroprene
-Chlorobutadiene
-
-NZ_CCID:
-2-Chloro-1,3-butadiene, 2-Chlorobutadiene, Chloroprene",126-99-8,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2007e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/67CEB265-6F61-4F99-AAAA-24B792CD6BF2","JP_CHRIP:
-Based on a report that after occlusive application to the skin of rabbits, mild to moderate erythema with edema was observed at 24-hour, and mild to moderate erythema persisted until 48-hour (SIDS (1998)), the substance was classified into Category 2. As relevant information, the substance is classified into Xi; R36/37/38 in EU classification.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Severe
-REFERENCE SOURCE: National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. (OTS0535986) [RTECS]
-Eye Irritation
-SPECIES:
-RESULT: Conjuntivitis and corneal necrosis
-REFERENCE SOURCE: IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer,1972-PRESENT. (Multivolume work).,p. V19 138 (1979) [HSDB]",,"JP_CHRIP, NZ_CCID",2,ClC(=C)C=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J384K,J-GLOBAL,C=CC(=C)Cl,Train,1,2702,training
-"NZ_CCID:
-Pyruvic acid",,127-17-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6CFC8481-1473-4106-B404-4CA959F7F838,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(=O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/1060,PubChem,CC(=O)C(=O)O,Train,1,2702,training
-"JP_CHRIP:
-Tetrachloroethylene
-
-KR_NCIS:
-Tetrachloroethylene
-
-NZ_CCID:
-Ethene, tetrachloro-, (perchloroethylene)
-
-US_HSDB:
-Tetrachloroethylene","JP_CHRIP:
-1,1,2,2-Tetrachloroethene
-1,1,2,2-Tetrachloroethylene
-Ethylene tetrachloride
-perc
-Perchloroethylene
-Perclene
-Tetrachloroethene
-Tetrachloroethylene
-Tetrachloroethylene (Perchloroethylene)
-Tetrachloroethylene; Perchloroethylene
-
-NZ_CCID:
-1,1,2,2-Tetrachloroethene, Ethylene tetrachloride, PCE, Perchlorethylene, Tetrachloroethylene, perchloroethylene",127-18-4,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2094e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5662214B-942C-44BD-8756-8BD9B83049F1
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/124","JP_CHRIP:
-There are reports that ""In persons whose thumbs were immersed in the substance, a slight, moderate or strong burning sensation persisted for approx. 10 minutes. The pain subsided within one hour. Severe erythema persisted for 1 - 2-hour post exposure in all subjects"" (Hazard Assessment Report (CERI, NITE) No. 65 (2005)) and ""Extensive skin redness and blistering were seen in two workers who had laid unconscious in the substance-soaked clothes"" (CICAD No. 68 (2006)). In a rabbit skin irritation test (4-hour application), ""marked irritation"" was observed, however, no corrosive effect was observed (CICAD No. 68 (2006)). Based on these information, the substance was classified into Category 2.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Highly irritating
-REFERENCE SOURCE: Enichem S.p.A. Milan (235) VAN BEEK, L.: Investigation of a possibility to reduce the use of rabbits in
-Skin Irritation tests; experiments with dichloromethane, trichloroethylene, tetrachloroethylene and 1,1,1-trichloroethane. TNO-CIVO Institutes report V 89-265, ZEIST, NL p 1-19 (1990) (iuclid 2000)
-Eye Irritation
-SPECIES: Human
-RESULT: Liquid perchloroethylene may cause pain, lacrimation, and burning; however, permanent injury is unlikely. High concentrations of the vapors are uncomfortable to the eyes.
-REFERENCE SOURCE: Enichem S.p.A. Milan
-(237) PATTY S INDUSTRIAL HYGIENE AND TOXICOLOGY, 3rd REVISED EDITION. Volume 2B, p 3562, A WILEY-INTERSCIENCE PUBLICATION, JOHN WILEY & SONS, NY.... (1981) (iuclid 2000)",,"JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",4,ClC(=C(Cl)Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.261A,J-GLOBAL,ClC(Cl)=C(Cl)Cl,Train,1,2702,training
-"JP_CHRIP:
-N,N-Dimethylacetamide","JP_CHRIP:
-Acetic acid dimethylamide
-Dimethylacetamide",127-19-5,NC,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2012.html,"JP_CHRIP:
-【分類根拠】
-（１）、（２）より、区分に該当しない。
-
-【根拠データ】
-（１）ウサギ（n=2）を用いた皮膚刺激性試験（OECD TG 404相当、閉塞、20時間適用、7日観察）において、全例で24時間後及び72時間後に軽度の紅斑がみられたが、7日以内に回復したとの報告がある（AICIS IMAP (2013)、REACH登録情報 (Accessed Aug. 2021)）。
-（２）ウサギ（n=2/群）を用いた皮膚刺激性試験において、最大で500 mg/kgの原液を適用したところ、皮膚刺激性はみられなかったとの報告がある（SIAR (2001)、AICIS IMAP (2013) REACH登録情報 (Accessed Aug. 2021)）。",Provided,JP_CHRIP,1,CN(C)C(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.517H,J-GLOBAL,CC(=O)N(C)C,Train,1,2702,training
-"AU_HCIS:
-3-Buten-2-one, 4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-, (E)-",,127-41-3,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5903,,,AU_HCIS,1,CC1=CCCC(C1/C=C/C(=O)C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/5282108,PubChem,CC(=O)/C=C/C1C(C)=CCCC1(C)C,Train,1,2702,training
-"AU_HCIS:
-1-Penten-3-one, 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-, [R-(E)]-",,127-42-4,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5904,,,AU_HCIS,1,CCC(=O)/C=C/[C@H]1C(=CCCC1(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/16751505,PubChem,CCC(=O)/C=C/[C@H]1C(C)=CCCC1(C)C,Train,1,2702,training
-"AU_HCIS:
-1-Penten-3-one, 1-(2,6,6-trimethyl-1-cyclohexen-1-yl)-",,127-43-5,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5905,,,AU_HCIS,1,CCC(=O)/C=C/C1=C(CCCC1(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/5375218,PubChem,CCC(=O)/C=C/C1=C(C)CCCC1(C)C,Train,1,2702,training
-"EU_REACH:
-diphenyl sulphone",,127-63-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13714/7/4/2/?documentUUID=d8363b87-1ec2-40ec-8a25-998e840933e5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)S(=O)(=O)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/31386,PubChem,O=S(=O)(c1ccccc1)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-Lysol",,12772-68-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6F8E833A-3060-4AF5-89F1-1C0970CD36C7,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(CCN)C[C@@H](CO)N,https://pubchem.ncbi.nlm.nih.gov/compound/11607920,PubChem,NCCCC[C@H](N)CO,Train,1,2702,training
-"AU_HCIS:
-Bicyclo[3.1.1]heptane, 6,6-dimethyl-2-methylene-
-
-JP_CHRIP:
-beta-Pinene
-
-NZ_CCID:
-Bicyclo[3.1.1]heptane, 6,6-dimethyl-2-methylene-","NZ_CCID:
-2(10)-Pinene, Nopinen, Nopinene, Pseudopinene",127-91-3,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5933
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0043e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5C652EE6-E358-4EC6-8A02-DFD79D955D15","JP_CHRIP:
-The substance was classified as Category 2 based on the documented case of ""moderately irritating"" resulted from rabbit test (DFGMAK-Doc. 17 (2002)). As relevant notes, erythema and edema was reported for the patch test that applied 70 - 80% olive oil preparation liquid to 28 patients with the skin disease (DFGMAK-Doc. 17 (2002)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Moderate irritant
-REFERENCE SOURCE: [http://physchem.ox.ac.uk/MSDS/PI/beta-pinene.html]
-Eye Irritation
-SPECIES:
-RESULT: Irritant
-REFERENCE SOURCE: [http://physchem.ox.ac.uk/MSDS/PI/beta-pinene.html]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CC1(C)C2CC1C(=C)CC2,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.017F,J-GLOBAL,C=C1CCC2CC1C2(C)C,Train,1,2702,training
-"KR_NCIS:
-1,3-Dihydro-1,3-dioxo-2H-isoindole-2-hexaneperoxoic acid","KR_NCIS:
-1,3-Dihydro-1,3-dioxo-2H-isoindole-2-hexaneperoxoic acid; 2H-Isoindole-2-hexaneperoxoic acid, 1,3-dihydro-1,3-dioxo-; 5-(Phthalimido)percaproic acid; 6-(Phthalimido)peroxyhexanoic acid; 6-(Phthalimidoperoxy)hexanoic acid; 6-Phthalimidohexaneperoxoic acid; Phthalimidoperhexanoic acid",128275-31-0,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C1=CC=C2C(=C1)C(=O)N(C2=O)CCCCCC(=O)OO,https://pubchem.ncbi.nlm.nih.gov/compound/9860421,PubChem,O=C(CCCCCN1C(=O)c2ccccc2C1=O)OO,Train,1,2702,training
-"EU_REACH:
-2,6-di-tert-butylphenol",,128-39-2,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14369/7/4/2/?documentUUID=f330a614-d6f5-4920-9cdd-645fa0279790,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1=C(C(=CC=C1)C(C)(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/31405,PubChem,CC(C)(C)c1cccc(C(C)(C)C)c1O,Train,1,2702,training
-"EU_REACH:
-(1s,4r)-4-(but-3-en-1-yl)-4'-(4-methylphenyl)-1,1'-bi(cyclohexane)",,129738-42-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30434/7/4/2/?documentUUID=1db48264-a8f7-4804-a695-90416161d657,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)C2CCC(CC2)C3CCC(CC3)CCC=C,https://pubchem.ncbi.nlm.nih.gov/compound/18724321,PubChem,C=CCCC1CCC(C2CCC(c3ccc(C)cc3)CC2)CC1,Train,1,2702,training
-"EU_REACH:
-2-[(benzyloxy)(4-ethoxyphenyl)methyl]-4-bromo-1-chlorobenzene",,1298086-15-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11443/7/4/2/?documentUUID=bc8a770f-791c-4f18-b19f-f2810163a6b5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=CC=C(C=C1)C(C2=C(C=CC(=C2)Br)Cl)OCC3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/67153917,PubChem,CCOc1ccc(C(OCc2ccccc2)c2cc(Br)ccc2Cl)cc1,Train,1,2702,training
-"NZ_CCID:
-5-Chloro-8-quinolinol","NZ_CCID:
-cloxyquin",130-16-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AB624CF2-CA2F-4E28-9A37-84A82A88738F,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC2=C(C=CC(=C2N=C1)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/2817,PubChem,Oc1ccc(Cl)c2cccnc12,Train,1,2702,training
-"NZ_CCID:
-1,3,5-Tributylhexahydro-1,3,5-triazine",,13036-83-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/27CDEAA1-0EE0-4796-A5A6-81548E0F9215,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCCCN1CN(CN(C1)CCCC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/83069,PubChem,CCCCN1CN(CCCC)CN(CCCC)C1,Train,1,2702,training
-"NZ_CCID:
-1,6-Hexanediol diacrylate","NZ_CCID:
-Hexanediol diacrylate",13048-33-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0644B1AF-3855-40CF-8AD9-4018878F1C53,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]
-Eye Irritation
-R PHRASE: R 36 [ECB]",,NZ_CCID,1,C=CC(=O)OCCCCCCOC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/25644,PubChem,C=CC(=O)OCCCCCCOC(=O)C=C,Train,1,2702,training
-"EU_REACH:
-5-[(2-ethylhexanoyl)peroxy]-2,5-dimethylhexan-2-yl 2-ethylhexaneperoxoate",,13052-09-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11958/7/4/2/?documentUUID=f5fab42f-11f4-4370-8c59-87c48600fb98,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)C(=O)OOC(C)(C)CCC(C)(C)OOC(=O)C(CC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/114448,PubChem,CCCCC(CC)C(=O)OOC(C)(C)CCC(C)(C)OOC(=O)C(CC)CCCC,Train,1,2702,training
-"EU_REACH:
-5-amino-4-({5-amino-3-cyano-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazol-4-yl}disulfanyl)-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile",,130755-46-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18253/7/4/2/?documentUUID=14ff8475-0c99-4ba2-86ba-0f97d4ffbdad,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(C=C(C(=C1Cl)N2C(=C(C(=N2)C#N)SSC3=C(N(N=C3C#N)C4=C(C=C(C=C4Cl)C(F)(F)F)Cl)N)N)Cl)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/11146906,PubChem,N#Cc1nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c(N)c1SSc1c(C#N)nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1N,Train,1,2702,training
-"EU_REACH:
-(2Z)-2-phenylhex-2-enenitrile",,130786-09-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30707/7/4/2/?documentUUID=2360e3ed-e8ac-41ab-aaaf-63b3f67bd5b3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC/C=C(\C#N)/C1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/5463415,PubChem,CCC/C=C(\C#N)c1ccccc1,Train,1,2702,training
-"EU_REACH:
-Methyl 1-(3-chloropyridin-2-yl)-5-hydroxy-3-(hydroxymethyl)-4,5-dihydro-1H-pyrazole-5-carboxylate",,1312304-36-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16308/7/4/2/?documentUUID=5a012298-7c10-46fb-adbe-64c52bf1408d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1(CC(=NN1C2=C(C=CC=N2)Cl)CO)O,https://pubchem.ncbi.nlm.nih.gov/compound/54577408,PubChem,COC(=O)C1(O)CC(CO)=NN1c1ncccc1Cl,Train,1,2702,training
-"EU_REACH:
-4-{[(4-benzoylphenoxy)carbonyl]oxy}butyl prop-2-enoate",,131513-00-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12627/7/4/2/?documentUUID=5e65537c-ceb5-4439-800d-d4785a38627e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CC(=O)OCCCCOC(=O)OC1=CC=C(C=C1)C(=O)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/14746151,PubChem,C=CC(=O)OCCCCOC(=O)Oc1ccc(C(=O)c2ccccc2)cc1,Train,1,2702,training
-"NZ_CCID:
-Chlorotriisopropylsilane","NZ_CCID:
-triisopropylchlorosilane",13154-24-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/30EB817D-6B8E-4B7B-82A8-47766864A1A9,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)[Si](C(C)C)(C(C)C)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/139400,PubChem,CC(C)[Si](Cl)(C(C)C)C(C)C,Train,1,2702,training
-"US_HSDB:
-Benzophenone-2",,131-55-5,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8386,,,US_HSDB,1,C1=CC(=C(C=C1O)O)C(=O)C2=C(C=C(C=C2)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/8571,PubChem,O=C(c1ccc(O)cc1O)c1ccc(O)cc1O,Train,1,2702,training
-"EU_REACH:
-triphenyl[(2E,4E,6E)-3,7,11-trimethyldodeca-2,4,6,10-tetraen-1-yl]-λ⁵-phosphane",,131560-11-7,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30300/7/4/2/?documentUUID=1d845d32-da16-42cb-8e45-41f877da34d9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=CCCC(=CC=CC(=CC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/73090499,PubChem,CC(C)=CCCC(C)=CC=CC(C)=CC[P+](c1ccccc1)(c1ccccc1)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-2,4-Dihydroxybenzophenone",,131-56-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/28089033-E31A-40C9-95E7-8C8A7706513F,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C(C=C1)C(=O)C2=C(C=C(C=C2)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/8572,PubChem,O=C(c1ccccc1)c1ccc(O)cc1O,Train,1,2702,training
-"EU_REACH:
-N-vinylformamide",,13162-05-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15886/7/4/2/?documentUUID=bb17fd9c-f5cd-473b-892a-95470e93d4c1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CNC=O,https://pubchem.ncbi.nlm.nih.gov/compound/83191,PubChem,C=CNC=O,Train,1,2702,training
-"JP_CHRIP:
-Ammonium picrate",,131-74-8,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2107e.html,"JP_CHRIP:
-[Rationale for the Classification]
-Based on (1), it was classified in Category 2.
-
-[Evidence Data]
-(1) This substance was moderately irritating to the skin, eyes and mucous membranes (HSDB (Access on October 2019)).",,JP_CHRIP,1,[N+]Oc1c(cc(cc1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J95.840I,J-GLOBAL,[N+]Oc1c([N+](=O)[O-])cc([N+](=O)[O-])cc1[N+](=O)[O-],Train,1,2702,training
-"JP_CHRIP:
-2,4-Dinitro-6-cyclohexylphenol; Dinex","JP_CHRIP:
-Phenol, 2-cyclohexyl-4,6-dinitro-",131-89-5,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2108e.html,"JP_CHRIP:
-[Rationale for the Classification]
-Based on (1) and (2), it was classified in Category 1. The category was changed since new data were obtained.
-
-[Evidence Data]
-(1) This substance had irritative to corrosive effects on the mucous membranes and skin (GESTIS (Access on October 2019)).
-(2) This substance is a skin irritant (HSDB (Access on October 2019)).",,JP_CHRIP,1,Oc1c(cc(cc1[N+](=O)[O-])[N+](=O)[O-])C1CCCCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.945I,J-GLOBAL,O=[N+]([O-])c1cc(C2CCCCC2)c(O)c([N+](=O)[O-])c1,Train,1,2702,training
-"NZ_CCID:
-Methylstyrene (mixture of 3- and 4-isomers), >26% in a non hazardous diluent",,1319-73-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4A9D40C0-2713-40E7-8339-C95F43482689,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=CC=C(C=C1)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/12161,PubChem,C=Cc1ccc(C)cc1,Train,1,2702,training
-"EU_REACH:
-dodecyl(2-hydroxy-3-sulphonatopropyl)dimethylammonium",,13197-76-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22843/7/4/2/?documentUUID=2d9f55e3-2288-4fc7-913c-a969d0eb6a54,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCC[N+](C)(C)CC(CS(=O)(=O)[O-])O,https://pubchem.ncbi.nlm.nih.gov/compound/114474,PubChem,CCCCCCCCCCCC[N+](C)(C)CC(O)CS(=O)(=O)[O-],Train,1,2702,training
-"AU_HCIS:
-Phenol, 4-methyl-2-nonyl-",,13207-27-7,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6708,,,AU_HCIS,1,CCCCCCCCCC1=C(C=CC(=C1)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/83233,PubChem,CCCCCCCCCc1cc(C)ccc1O,Train,1,2702,training
-"NZ_CCID:
-1,2-Bis(dibromomethyl)-benzene",,13209-15-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/052BCD7A-6DAD-49AF-B780-8BB05811E601,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C(C(=C1)C(Br)Br)C(Br)Br,https://pubchem.ncbi.nlm.nih.gov/compound/83234,PubChem,BrC(Br)c1ccccc1C(Br)Br,Train,1,2702,training
-"EU_CLP:
-penthachloronaphthalene",,1321-64-8,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=C(C=C(C2=C1C(=C(C=C2Cl)Cl)Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/114760,PubChem,Clc1cc(Cl)c2c(Cl)cc(Cl)c(Cl)c2c1,Test,1,2702,training
-"EU_REACH:
-1,1,1,2,2,3,4,5,5,5-decafluoro-3-methoxy-4-(trifluoromethyl)pentane",,132182-92-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27778/7/4/2/?documentUUID=3af099f4-2dfc-4acf-b646-fe27a33bc682,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(C(C(F)(F)F)(C(F)(F)F)F)(C(C(F)(F)F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/14689855,PubChem,COC(F)(C(F)(F)C(F)(F)F)C(F)(C(F)(F)F)C(F)(F)F,Train,1,2702,training
-"AU_HCIS:
-Phenol, dinonyl-",,1323-65-5,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6840,,,AU_HCIS,1,CCCCCCCCCC1=C(C(=CC=C1)O)CCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/172321,PubChem,CCCCCCCCCc1cccc(O)c1CCCCCCCCC,Train,1,2702,training
-"EU_REACH:
-[[4-[[4-(anilino)phenyl][4-(phenylimino)-2,5-cyclohexadien-1-ylidene]methyl]phenyl]amino]benzenesulphonic acid",,1324-76-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5364/7/4/2/?documentUUID=4bf44719-5090-4d63-a5f5-9ad1bcb13f63,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,O[S](=O)(=O)c1ccccc1N=C2C=CC(C=C2)=C(c3ccc(Nc4ccccc4)cc3)c5ccc(Nc6ccccc6)cc5,https://cactus.nci.nih.gov/chemical/structure/1324-76-1/smiles,CACTUS,O=S(=O)(O)c1ccccc1N=C1C=CC(=C(c2ccc(Nc3ccccc3)cc2)c2ccc(Nc3ccccc3)cc2)C=C1,Test,1,2702,training
-"EU_REACH:
-2-methoxy-4-methylphenyl methyl carbonate",,132638-45-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16996/7/4/2/?documentUUID=ef72fade-5798-4cbb-94b8-11b52259b21a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)OC(=O)OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/15636422,PubChem,COC(=O)Oc1ccc(C)cc1OC,Train,1,2702,training
-"NZ_CCID:
-Benzene, 1,4-bis[2-(2-methylphenyl)ethenyl]-",,13280-61-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C8377D83-E6E3-4E8B-80C6-D1E7044A4AC3,,,NZ_CCID,1,CC1=CC=CC=C1/C=C/C2=CC=C(C=C2)/C=C/C3=CC=CC=C3C,https://pubchem.ncbi.nlm.nih.gov/compound/5378735,PubChem,Cc1ccccc1/C=C/c1ccc(/C=C/c2ccccc2C)cc1,Train,1,2702,training
-"EU_REACH:
-2-methylbenzene-1,4-diyl bis{4-[4-(acryloyloxy)butoxy]benzoate}",,132900-75-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1861/7/4/2/?documentUUID=44f459cc-4c69-4464-a0b8-6956d992e903,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=CC(=C1)OC(=O)C2=CC=C(C=C2)OCCCCOC(=O)C=C)OC(=O)C3=CC=C(C=C3)OCCCCOC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/9917022,PubChem,C=CC(=O)OCCCCOc1ccc(C(=O)Oc2ccc(OC(=O)c3ccc(OCCCCOC(=O)C=C)cc3)c(C)c2)cc1,Train,1,2702,training
-"NZ_CCID:
-Acetic acid, (1,2-cyclohexylenedinitrilo)tetra-, trans-",,13291-61-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7D6529C6-0DA8-454E-BD7B-5FAA9A5687D7,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 36/37/38
-Eye Irritation
-R-PHRASE: R 36/37/38",,NZ_CCID,1,C1CC[C@H]([C@@H](C1)N(CC(=O)O)CC(=O)O)N(CC(=O)O)CC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/2723845,PubChem,O=C(O)CN(CC(=O)O)[C@@H]1CCCC[C@H]1N(CC(=O)O)CC(=O)O,Train,1,2702,training
-"EU_REACH:
-N-benzylprop-2-enamide",,13304-62-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29488/7/4/2/?documentUUID=9ea5bc25-7c80-47c1-aa69-9602849dea2f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CC(=O)NCC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/139428,PubChem,C=CC(=O)NCc1ccccc1,Train,1,2702,training
-"EU_REACH:
-2-[(2-hydroxyphenyl)methyl]phenol; 2-[(4-hydroxyphenyl)methyl]phenol; 4-[(4-hydroxyphenyl)methyl]phenol",,1333-16-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26309/7/4/2/?documentUUID=794c4abc-1efd-4ddb-8794-a80cc844903d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=C1)CC2=CC=CC=C2O)O,https://pubchem.ncbi.nlm.nih.gov/compound/75575,PubChem,Oc1ccccc1Cc1ccccc1O,Train,1,2702,training
-"EU_REACH:
-2-{2-[(2R,4R,6R)-4,6-dihydroxyoxan-2-yl]ethyl}-2,3-dihydro-1H-isoindole-1,3-dione",,1333481-90-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23605/7/4/2/?documentUUID=b08b59c2-50f9-4672-a89b-e517168cdbbc,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1[C@H](C[C@@H](O[C@@H]1CCN2C(=O)C3=CC=CC=C3C2=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/90262225,PubChem,O=C1c2ccccc2C(=O)N1CC[C@@H]1C[C@@H](O)C[C@H](O)O1,Train,1,2702,training
-"EU_REACH:
-2-[(1E)-2-(2,4-diamino-6-hydroxypyrimidin-5-yl)diazen-1-yl]-5-methylbenzene-1-sulfonic acid",,1333483-07-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5819/7/4/2/?documentUUID=cb160d38-b650-45c7-ae8e-b04ab65e2aff,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(=CC=C1)S(=O)(=O)O)N=NC2=C(N=C(NC2=O)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/165364080,PubChem,Cc1cccc(S(=O)(=O)O)c1N=Nc1c(N)nc(N)[nH]c1=O,Train,1,2702,training
-"EU_REACH:
-Propan-2-yl N-[(S)-(pentafluorophenoxy)(phenoxy)-phosphoryl]-L-alanine",,1334513-02-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18410/7/4/2/?documentUUID=1228c885-efe1-45b0-b456-7b0082625a2a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC1=CC=CC=C1)OC2=C(C(=C(C(=C2F)F)F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/53476763,PubChem,CC(C)OC(=O)[C@H](C)N[P@](=O)(Oc1ccccc1)Oc1c(F)c(F)c(F)c(F)c1F,Train,1,2702,training
-"KR_NCIS:
-Dimethylsulfamoyl chloride
-
-NZ_CCID:
-Dimethylsulphamoyl chloride","KR_NCIS:
-Dimethylaminosulfonyl chloride; Dimethylsulfamoyl chloride; N,N-Dimethylaminosulfonyl chloride; N,N-Dimethylsulfamyl chloride; Sulfamoyl chloride, dimethyl-; Sulfamoyl chloride, N,N-dimethyl-
-
-NZ_CCID:
-N,N-Dimethylsulfamoyl chloride, dimethylsulfamoyl chloride",13360-57-1,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/88D9317E-FE3C-4472-9A72-43E3F3DE1CEC","NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"KR_NCIS, NZ_CCID",2,CN(C)S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/83372,PubChem,CN(C)S(=O)(=O)Cl,Train,1,2702,training
-"EU_REACH:
-2-ethylhexyl 2-cyanoacetate",,13361-34-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1727/7/4/2/?documentUUID=f16a9af2-90b6-47ea-98b4-85b6a4c3981d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)CC#N,https://pubchem.ncbi.nlm.nih.gov/compound/96359,PubChem,CCCCC(CC)COC(=O)CC#N,Train,1,2702,training
-"AU_HCIS:
-2-Butanone, peroxide
-
-KR_NCIS:
-2-Butanone, peroxide
-
-NZ_CCID:
-2-Butanone, peroxide 33-40% in dimethyl phthalate + 1-10% methyl ethyl ketone","KR_NCIS:
-Ethyl methyl ketone peroxide; Methyl ethyl ketone hydroperoxide; MEKP
-
-NZ_CCID:
-2-Butanone, peroxide, Butanox LPT, Ethyl methyl ketone peroxide, Ketonox, Mepox, Methyl ethyl ketone hydroperoxide, Methyl ethyl ketone peroxide",1338-23-4,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5494
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5444433B-0981-4A1D-AE16-7F47D7AC6E5A","NZ_CCID:
-Skin Irritation
-SPECIES:
-RESULT: Corrosive to skin and mucous membrane.
-REFERENCE SOURCE: Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. II-108]**PEER REVIEWED**
-[HSDB]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Severe (graded 6 on a scale of 0 to 7)
-REFERENCE SOURCE: [QC Reviewed] Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986. 618. [HSDB]",,"AU_HCIS, KR_NCIS, NZ_CCID",3,CCC(C)(OO)OOC(C)(CC)OO,https://pubchem.ncbi.nlm.nih.gov/compound/3672772,PubChem,CCC(C)(OO)OOC(C)(CC)OO,Train,1,2702,training
-"NZ_CCID:
-Napthenic acid
-
-US_HSDB:
-NAPHTHENIC ACIDS",,1338-24-5,Cat 2,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1BC03C46-23C0-4740-BC0E-35F3C0113733
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1178","NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Sigma-Aldrich]
-Eye Irritation
-R PHRASE: R 36 [Sigma-Aldrich]",,"NZ_CCID, US_HSDB",2,CCC1CCC(C1)CCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/20849290,PubChem,CCC1CCC(CCC(=O)O)C1,Train,1,2702,training
-"EU_REACH:
-1-{[(2R,3R)-3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole",,133855-98-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33675/7/4/2/?documentUUID=527ed234-8fb4-4233-94ee-b2a9e3e614ed,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=C1)C2C(O2)(CN3C=NC=N3)C4=CC=C(C=C4)F)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/3317081,PubChem,Fc1ccc(C2(Cn3cncn3)OC2c2ccccc2Cl)cc1,Train,1,2702,training
-"NZ_CCID:
-Benzoic acid, 2-amino-, methyl ester","NZ_CCID:
-2-Aminobenzoic acid, methyl ester, 2-Carbomethoxyaniline, Methyl 2-aminobenzoate, Methyl Anthranilate, o-Aminobenzoic acid methyl ester",134-20-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/03C8D917-F78C-4367-9102-6B6563AB00A8,,,NZ_CCID,1,COC(=O)C1=CC=CC=C1N,https://pubchem.ncbi.nlm.nih.gov/compound/8635,PubChem,COC(=O)c1ccccc1N,Train,1,2702,training
-"JP_CHRIP:
-N,N-diethyl-m-toluamide; deet; diethyltoluamide
-
-NZ_CCID:
-Diethyl toluamide
-
-US_HSDB:
-DEET","JP_CHRIP:
-N,N-diethyl-m-toluamide
-
-NZ_CCID:
-DEET",134-62-3,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0192e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EA0F8381-75AA-4D0D-9192-03708E76E647
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1582","JP_CHRIP:
-Since application of this substance produced mild to moderate erythema in rabbits (HSDB, 2003), the substance was classified into Category 2.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Produced moderate erythema and oedema to skin of albino rabbits following 4hr exposure. All irritation subsided within 7 days.
-REFERENCE SOURCE: [Handbook of Pesticide Toxicology, 2nd Edition]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Slight corneal opacity and slight to moderate conjunctive irritation in the form of redness, swelling and discahrge were observed. All occular irritation cleared within 7 days.
-REFERENCE SOURCE: [Handbook of Pesticide Toxicology, 2nd Edition]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,CCN(CC)C(=O)c1cccc(C)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.598K,J-GLOBAL,CCN(CC)C(=O)c1cccc(C)c1,Train,1,2702,training
-"AU_HCIS:
-Bicyclo[4.1.0]hept-3-ene, 3,7,7-trimethyl-
-
-KR_NCIS:
-3,7,7-Trimethylbicyclo[4.1.0]hept-3-ene",,13466-78-9,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6462
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,"AU_HCIS, KR_NCIS",2,CC1=CCC2C(C1)C2(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/26049,PubChem,CC1=CCC2C(C1)C2(C)C,Train,1,2702,training
-"EU_CLP:
-4,4'-methylenebis(N,N'-dimethylcyclohexanamine",,13474-64-1,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CN(C)C1CCC(CC1)CC2CCC(CC2)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/13387427,PubChem,CN(C)C1CCC(CC2CCC(N(C)C)CC2)CC1,Test,1,2702,training
-"NZ_CCID:
-Benzil",,134-81-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5A439536-1DB5-4E44-ADEB-E7F4E03F53EE,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)C(=O)C(=O)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/8651,PubChem,O=C(C(=O)c1ccccc1)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-4-Chlorobenzhydryl chloride",,134-83-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C26566B0-FB81-4F08-A13D-1D1AC90BD2A6,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)C(C2=CC=C(C=C2)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/241584,PubChem,Clc1ccc(C(Cl)c2ccccc2)cc1,Train,1,2702,training
-"EU_REACH:
-(4-methylphenyl)(phenyl)methanone",,134-84-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21484/7/4/2/?documentUUID=38e2b668-7b0e-4819-8307-4024f124a40a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)C(=O)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/8652,PubChem,Cc1ccc(C(=O)c2ccccc2)cc1,Train,1,2702,training
-"EU_REACH:
-(3-chloropropyl)(diethoxymethyl)silane; (3-chloropropyl)diethoxymethylsilane; (4-chloro-1,1-diethoxybutyl)silane",,13501-76-3,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5347/7/4/2/?documentUUID=e0177c9a-f6ec-4003-a81e-73af77e25805,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](C)(CCCCl)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/83536,PubChem,CCO[Si](C)(CCCCl)OCC,Train,1,2702,training
-"NZ_CCID:
-2-Methoxybenzaldehyde","NZ_CCID:
-o-anisaldehyde",135-02-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B6470541-B9B1-4847-ADA7-AF59D696825E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,COC1=CC=CC=C1C=O,https://pubchem.ncbi.nlm.nih.gov/compound/8658,PubChem,COc1ccccc1C=O,Train,1,2702,training
-"EU_REACH:
-2-[(4-chloro-2-nitrophenyl)diazenyl]-N-(2-methoxyphenyl)-3-oxobutanamide",,13515-40-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11102/7/4/2/?documentUUID=e2553dc2-1a6f-4306-9442-f7629fc6d411,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC=CC=C1OC)N=NC2=C(C=C(C=C2)Cl)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/61637,PubChem,COc1ccccc1NC(=O)C(N=Nc1ccc(Cl)cc1[N+](=O)[O-])C(C)=O,Train,1,2702,training
-"EU_REACH:
-2-naphthol
-
-JP_CHRIP:
-beta Naphthol","JP_CHRIP:
-2-Hydroxynaphthalene
-2-Naphthalenol
-beta-naphthol
-Isonaphthol",135-19-3,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26470/7/4/2/?documentUUID=67f1a7e2-d562-4fc8-a780-552cdfa9d077
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-meti-0016e.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-It is described that, in a skin irritation test with rabbits (OECD TG 404), after 500 mg of this substance was applied under semi-occlusive conditions for 4 hours, the Draize score was 0 (SIDS (2006)). From the above, this substance was classified as ""Not classified.""",Provided,"EU_REACH, JP_CHRIP",2,Oc1ccc2ccccc2c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.530E,J-GLOBAL,Oc1ccc2ccccc2c1,Train,1,2702,training
-"EU_REACH:
-1-(3-bicyclo[2.2.1]heptanyl)hex-5-en-2-one",,1352216-91-1,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29495/7/4/2/?documentUUID=66437282-0aa5-465d-8abf-f1d1307c88a9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CCCC(=O)CC1CC2CCC1C2,https://pubchem.ncbi.nlm.nih.gov/compound/89406615,PubChem,C=CCCC(=O)CC1CC2CCC1C2,Train,1,2702,training
-"EU_REACH:
-1-(3-chloropyridin-2-yl)-3-{[5-(trifluoromethyl)-2H-1,2,3,4-tetrazol-2-yl]methyl}-1H-pyrazole-5-carboxylic acid",,1352319-02-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19268/7/4/2/?documentUUID=d30d6a9c-20ab-4c5e-aebb-9064afa10598,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(N=C1)N2C(=CC(=N2)CN3N=C(N=N3)C(F)(F)F)C(=O)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/67289880,PubChem,O=C(O)c1cc(Cn2nnc(C(F)(F)F)n2)nn1-c1ncccc1Cl,Train,1,2702,training
-"EU_REACH:
-ethyl 4-methyl-2-oxocyclohexane-1-carboxylate",,13537-82-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27448/7/4/2/?documentUUID=813c0797-d8f0-4008-902d-1256490bbae3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1CCC(CC1=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/98162,PubChem,CCOC(=O)C1CCC(C)CC1=O,Train,1,2702,training
-"JP_CHRIP:
-1-Chloro-3,3-dimethyl-2-butanone","JP_CHRIP:
-1-Chloro-3,3-dimethyl-2-butanone; 1-Chloro-3,3-dimethyl-2-butanone",13547-70-1,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0042e.html,"JP_CHRIP:
-On the basis of a ""highly irritating"" result in an occlusive test applied to rabbit skins for 4 hours (US-EPA-TSCA Health Effects Testing Guidelines and US-EPA-FIFRA, Pesticide Assessment Guidelines; GLP compliance) (IUCLID (2000)), it was classified in Category 2.
-Besides, details of a test which reported that an occlusive application to rabbit auricular skins for 1 to 8 hours resulted in corrosive (IUCLID (2000)) are unknown.",,JP_CHRIP,1,CC(C)(C)C(=O)CCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J241.183K,J-GLOBAL,CC(C)(C)C(=O)CCl,Train,1,2702,training
-"EU_REACH:
-3-hydroxy-N-(3-nitrophenyl)-2-naphthamide",,135-65-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18978/7/4/2/?documentUUID=213f5e70-3e96-4b39-8ebd-9bc66f1d7b42,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C=C(C(=CC2=C1)C(=O)NC3=CC(=CC=C3)[N+](=O)[O-])O,https://pubchem.ncbi.nlm.nih.gov/compound/67277,PubChem,O=C(Nc1cccc([N+](=O)[O-])c1)c1cc2ccccc2cc1O,Train,1,2702,training
-"NZ_CCID:
-2-Bromo-4'-phenylacetophenone",,135-73-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F81BA223-02A9-4A66-AF6E-3708D0692A20,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/67282,PubChem,O=C(CBr)c1ccc(-c2ccccc2)cc1,Train,1,2702,training
-"AU_HCIS:
-N-2-naphthylaniline
-
-NZ_CCID:
-N-Phenyl-2-naphthylamine","AU_HCIS:
-N-phenyl-2-naphthylamine
-
-NZ_CCID:
-2-Anilinonaphthalene, 2-Naphthalenamine, N-phenyl-, 2-Naphthylamine, N-phenyl-, 2-Naphthylphenylamine, 2-Phenylaminonaphthalene, N-(2-Naphthyl)aniline, N-2-Naphthylaniline, Neozone, Phenyl-2-naphthylamine",135-88-6,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3191
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AC618DFB-45E7-4686-89C4-2D1073F2EF8B","NZ_CCID:
-Skin Irritation
-R-PHRASE: R 38. [ECB]
-Eye Irritation
-R-PHRASE: R 36. [ECB]",,"AU_HCIS, NZ_CCID",2,C1=CC=C(C=C1)NC2=CC3=CC=CC=C3C=C2,https://pubchem.ncbi.nlm.nih.gov/compound/8679,PubChem,c1ccc(Nc2ccc3ccccc3c2)cc1,Train,1,2702,training
-"KR_NCIS:
-2-Isocyanatoethyl 2-propenoate",,13641-96-8,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C=CC(=O)OCCN=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/3014768,PubChem,C=CC(=O)OCCN=C=O,Train,1,2702,training
-"EU_REACH:
-2,6-dimethylphenyl 4-hydroxybenzene-1-sulfonate",,1364731-90-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6296/7/4/2/?documentUUID=0e0cc07b-3d6b-460f-ba72-c4fa60d156c7,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(=CC=C1)C)OS(=O)(=O)C2=CC=C(C=C2)O,https://pubchem.ncbi.nlm.nih.gov/compound/89798625,PubChem,Cc1cccc(C)c1OS(=O)(=O)c1ccc(O)cc1,Train,1,2702,training
-"NZ_CCID:
-Butyl benzoate",,136-60-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3AA04FC9-DD95-4163-937A-326B3B343335,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCCCOC(=O)C1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/8698,PubChem,CCCCOC(=O)c1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-Tris(dichloropropyl) phosphate","JP_CHRIP:
-Tris(1,3-dichloro-2-propyl) phosphate
-tris(1,3-dichloro-2-propyl)phosphate",13674-87-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0089e.html,"JP_CHRIP:
-In the rabbit test (OECD TG404, GLP-compliant) that 0.5 ml of test substance was instilled to 3 rabbits for 4 hours with semi-occlusive conditions, erythema (grade 2) was recorded in 2/3 animals after one hour and persisted for 24 hours in one animal. Erythema (grade 1) was noted in the third animal. There was no edema. All reactions disappeared within 48 hours (EU-RAR (2008)). Based on the document, the substance was classified as ""Not classified"".",Provided,JP_CHRIP,1,ClCC(CCl)OP(=O)(OC(CCl)CCl)OC(CCl)CCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J640H,J-GLOBAL,O=P(OC(CCl)CCl)(OC(CCl)CCl)OC(CCl)CCl,Train,1,2702,training
-"EU_REACH:
-1,8-bis(phenylsulfanyl)-9,10-dihydroanthracene-9,10-dione",,13676-91-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11269/7/4/2/?documentUUID=62f73577-a8ad-4bd2-bb4e-dee22c6bd943,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)SC2=CC=CC3=C2C(=O)C4=C(C3=O)C=CC=C4SC5=CC=CC=C5,https://pubchem.ncbi.nlm.nih.gov/compound/83650,PubChem,O=C1c2cccc(Sc3ccccc3)c2C(=O)c2c(Sc3ccccc3)cccc21,Train,1,2702,training
-"NZ_CCID:
-4-Hexylresorcinol",,136-77-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E718E048-6313-4F8B-9EFA-2326A11A7F92,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCCCCCC1=C(C=C(C=C1)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/3610,PubChem,CCCCCCc1ccc(O)cc1O,Train,1,2702,training
-"EU_REACH:
-4,4'-methylenebis(2,6-diethylaniline)",,13680-35-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21592/7/4/2/?documentUUID=e8334bc4-98cb-44bd-a2f7-0daf0ab3b068,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1=CC(=CC(=C1N)CC)CC2=CC(=C(C(=C2)CC)N)CC,https://pubchem.ncbi.nlm.nih.gov/compound/83656,PubChem,CCc1cc(Cc2cc(CC)c(N)c(CC)c2)cc(CC)c1N,Train,1,2702,training
-"KR_NCIS:
-Nonylphenols","KR_NCIS:
-2-Nonylphenol; o-Nonylphenol; Phenol, 2-nonyl-; Phenol, o-nonyl-",136-83-4,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCCCCCCCCC1=CC=CC=C1O,https://pubchem.ncbi.nlm.nih.gov/compound/67296,PubChem,CCCCCCCCCc1ccccc1O,Train,1,2702,training
-"EU_REACH:
-(5Z)-5-(2-methylpropylidene)imidazolidine-2,4-dione",,1369499-44-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20950/7/4/2/?documentUUID=904877a4-d525-4ba7-9aa1-d5f5e052771a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)/C=C\1/C(=O)NC(=O)N1,https://pubchem.ncbi.nlm.nih.gov/compound/13392838,PubChem,CC(C)/C=C1\NC(=O)NC1=O,Train,1,2702,training
-"EU_REACH:
-4,5-dihydro-2-undecyl-1H-imidazole-1-ethanol",,136-99-2,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26475/7/4/2/?documentUUID=74178948-b943-4a9b-9ba6-ecae27251ab3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCC1=NCCN1CCO,https://pubchem.ncbi.nlm.nih.gov/compound/8709,PubChem,CCCCCCCCCCCC1=NCCN1CCO,Train,1,2702,training
-"EU_CLP:
-2-chloro-5-sec-hexadecylhydroquinone",,137193-60-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCCCCCCCCCCCCCC(C)C1=CC(=C(C=C1O)Cl)O,https://pubchem.ncbi.nlm.nih.gov/compound/15034894,PubChem,CCCCCCCCCCCCCCC(C)c1cc(O)c(Cl)cc1O,Test,1,2702,training
-"EU_CLP:
-thiram (ISO); tetramethylthiuram disulphide",,137-26-8,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CN(C)C(=S)SSC(=S)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/5455,PubChem,CN(C)C(=S)SSC(=S)N(C)C,Test,1,2702,training
-"EU_REACH:
-N-isopropylmethacrylamide",,13749-61-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5438/7/4/2/?documentUUID=feb7e492-09bc-4da4-9e48-d35e43d2b7d8,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)NC(=O)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/83698,PubChem,C=C(C)C(=O)NC(C)C,Train,1,2702,training
-"NZ_CCID:
-Lidocaine","NZ_CCID:
-2,6-Acetoxylidide, 2-(diethylamino)-, Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-, Lignocaine",137-58-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/ADD6B89C-8D56-40B2-8877-286B6859D002,"NZ_CCID:
-Skin Irritation
-Data from related compound Lidocaine hydrochloride monohydrate (Cas no: 6108-05-0).
-R PHRASE: R 38
-[http://www.hommel-pharma.com/dateien/LIDO-HCL-e.PDF]
-Eye Irritation
-Data from related compound Lidocaine hydrochloride monohydrate (Cas no: 6108-05-0).
-R PHRASE: R 36
-[http://www.hommel-pharma.com/dateien/LIDO-HCL-e.PDF]
-Effects Below Cut Off",,NZ_CCID,1,CCN(CC)CC(=O)NC1=C(C=CC=C1C)C,https://pubchem.ncbi.nlm.nih.gov/compound/3676,PubChem,CCN(CC)CC(=O)Nc1c(C)cccc1C,Train,1,2702,training
-"EU_CLP:
-2-butyl-2-ethyl-1,5-diaminopentane",,137605-95-9,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCCCC(CC)(CCCN)CN,https://pubchem.ncbi.nlm.nih.gov/compound/4983344,PubChem,CCCCC(CC)(CN)CCCN,Test,1,2702,training
-"EU_REACH:
-2-[4,6-bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl]-5-{3-[(2-ethylhexyl)oxy]-2-hydroxypropoxy}phenol",,137658-79-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29511/7/4/2/?documentUUID=14a73c26-f93e-4e0d-8ddb-751101590bc6,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COCC(COC1=CC(=C(C=C1)C2=NC(=NC(=N2)C3=C(C=C(C=C3)C)C)C4=C(C=C(C=C4)C)C)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/135530657,PubChem,CCCCC(CC)COCC(O)COc1ccc(-c2nc(-c3ccc(C)cc3C)nc(-c3ccc(C)cc3C)n2)c(O)c1,Train,1,2702,training
-"KR_NCIS:
-(4R)-4-(1-Methylethyl)-1-cyclohexene-1-propanal",,1378867-81-2,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CC(C)[C@@H]1CCC(=CC1)CCC=O,https://pubchem.ncbi.nlm.nih.gov/compound/86680876,PubChem,CC(C)[C@H]1CC=C(CCC=O)CC1,Train,1,2702,training
-"NZ_CCID:
-Piperidine, 4-[3-(dichloromethylsilyl)propoxy]-2,2,6,6-tetramethyl-, hydrolyzed, polymd.",,137898-96-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6CDA1135-45B4-4EA8-B148-F9D2664446AD,,,NZ_CCID,1,CC1(CC(CC(N1)(C)C)OCCC[Si]C(Cl)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/53424536,PubChem,CC1(C)CC(OCCC[Si]C(Cl)Cl)CC(C)(C)N1,Train,1,2702,training
-"AU_HCIS:
-Phenol, 2,4-dinonyl-",,137-99-5,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5790,,,AU_HCIS,1,CCCCCCCCCC1=CC(=C(C=C1)O)CCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/8735,PubChem,CCCCCCCCCc1ccc(O)c(CCCCCCCCC)c1,Train,1,2702,training
-"EU_REACH:
-(7-methoxynaphthalen-1-yl)acetonitrile",,138113-08-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1437/7/4/2/?documentUUID=2e1fa2e0-e22a-4efa-81ad-c6493aa4c9cf,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC2=C(C=CC=C2CC#N)C=C1,https://pubchem.ncbi.nlm.nih.gov/compound/11264068,PubChem,COc1ccc2cccc(CC#N)c2c1,Test,1,2702,training
-"EU_REACH:
-3-(trimethoxysilyl)propylamine
-
-NZ_CCID:
-3-(Trimethoxysilyl)-propylamine","NZ_CCID:
-3-aminopropyltrimethoxysilane",13822-56-5,Cat 2,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14372/7/4/2/?documentUUID=8a198bca-5f82-4609-aaef-162e281c65af
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E206101C-DAF9-4149-B1D1-2BA0EA30D6BA","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",Provided,"EU_REACH, NZ_CCID",2,CO[Si](CCCN)(OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/83756,PubChem,CO[Si](CCCN)(OC)OC,Train,1,2702,training
-"EU_REACH:
-5-bromo-1,2,3-trifluorobenzene",,138526-69-9,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12569/7/4/2/?documentUUID=0be16503-49e9-4e6a-b97f-4c6035683622,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(C=C(C(=C1F)F)F)Br,https://pubchem.ncbi.nlm.nih.gov/compound/611409,PubChem,Fc1cc(Br)cc(F)c1F,Train,1,2702,training
-"EU_REACH:
-5-methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile",,138564-59-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32798/7/4/2/?documentUUID=8566bea1-5a59-4092-8e20-97bca0223339,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(S1)NC2=CC=CC=C2[N+](=O)[O-])C#N,https://pubchem.ncbi.nlm.nih.gov/compound/395460,PubChem,Cc1cc(C#N)c(Nc2ccccc2[N+](=O)[O-])s1,Train,1,2702,training
-"EU_REACH:
-9-[(3,3',5,5'-tetra-tert-butyl-2'-{8,10-dioxa-9-phosphatricyclo[9.4.0.0^{2,7}]pentadeca-1(11),2(7),3,5,12,14-hexaen-9-yloxy}-[1,1'-biphenyl]-2-yl)oxy]-8,10-dioxa-9-phosphatricyclo[9.4.0.0^{2,7}]pentadeca-1(11),2,4,6,12,14-hexaene",,138776-88-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17031/7/4/2/?documentUUID=c82a15b6-5fd9-4d8c-85f3-4b78ea53b406,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1=CC(=C(C(=C1)C(C)(C)C)OP2OC3=CC=CC=C3C4=CC=CC=C4O2)C5=C(C(=CC(=C5)C(C)(C)C)C(C)(C)C)OP6OC7=CC=CC=C7C8=CC=CC=C8O6,https://pubchem.ncbi.nlm.nih.gov/compound/10963933,PubChem,CC(C)(C)c1cc(-c2cc(C(C)(C)C)cc(C(C)(C)C)c2Op2oc3ccccc3c3ccccc3o2)c(Op2oc3ccccc3c3ccccc3o2)c(C(C)(C)C)c1,Test,1,2702,training
-"EU_REACH:
-2-{2-[2-(carboxymethoxy)ethoxy]ethoxy}acetic acid",,13887-98-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25085/7/4/2/?documentUUID=7fba0b6f-f04c-419f-8085-a493357cc89d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(COCC(=O)O)OCCOCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/83793,PubChem,O=C(O)COCCOCCOCC(=O)O,Train,1,2702,training
-"JP_CHRIP:
-p-Nitrosodimethylaniline",,138-89-6,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/07-mhlw-0030e.html,"JP_CHRIP:
-In light of reports that contact can irritate the skin and eyes (HSFS (2002)) and that it is highly irritating to skin (HSDB (2003)), the substance was classified into Category 2.",,JP_CHRIP,1,CN(C)c1ccc(cc1)N=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.628E,J-GLOBAL,CN(C)c1ccc(N=O)cc1,Train,1,2702,training
-"JP_CHRIP:
-nitrilotriacetic acid","JP_CHRIP:
-2,2',2''-nitrilotriacetic acid
-Aminotriacetic acid
-N,N-Bis(carboxymethyl)glycine
-Nitrilotriacetic acid and its salts
-NTA
-Tricollamic acid",139-13-9,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0167e.html,"JP_CHRIP:
-There are descriptions that it irritates human skin (HSFS (2001), SITTIG (2002)), and ""As this article is a strong acids, it is supposed to have irritation. There is no laboratory reports."" (CERI Hazard Data (2002)), So it was classified as Category 2.",,JP_CHRIP,1,OC(=O)CN(CC(=O)O)CC(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.533J,J-GLOBAL,O=C(O)CN(CC(=O)O)CC(=O)O,Train,1,2702,training
-"EU_REACH:
-3-{[bis(2,6-dimethylphenoxy)phosphoryl]oxy}phenyl bis(2,6-dimethylphenyl) phosphate",,139189-30-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33982/7/4/2/?documentUUID=acbd5ce7-2247-4889-9f5d-01969aac1969,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(=CC=C1)C)OP(=O)(OC2=CC(=CC=C2)OP(=O)(OC3=C(C=CC=C3C)C)OC4=C(C=CC=C4C)C)OC5=C(C=CC=C5C)C,https://pubchem.ncbi.nlm.nih.gov/compound/9874767,PubChem,Cc1cccc(C)c1OP(=O)(Oc1cccc(OP(=O)(Oc2c(C)cccc2C)Oc2c(C)cccc2C)c1)Oc1c(C)cccc1C,Train,1,2702,training
-"EU_REACH:
-methyl 2-[[4-(2-cyanophenyl)phenyl]methylamino]-3-nitrobenzoate",,139481-28-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18174/7/4/2/?documentUUID=361b625d-6119-4a0f-8115-c211a1de1dda,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=C(C(=CC=C1)[N+](=O)[O-])NCC2=CC=C(C=C2)C3=CC=CC=C3C#N,https://pubchem.ncbi.nlm.nih.gov/compound/15654651,PubChem,COC(=O)c1cccc([N+](=O)[O-])c1NCc1ccc(-c2ccccc2C#N)cc1,Train,1,2702,training
-"EU_REACH:
-Methyl 1-[(2’-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate",,139481-44-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18072/7/4/2/?documentUUID=70708469-5d76-4529-8f5d-2d6e1902f1b2,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C#N)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/15654674,PubChem,CCOc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2C#N)cc1,Train,1,2702,training
-"EU_REACH:
-2-ethoxy-1-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-1,3-benzodiazole-7-carboxylic acid",,139481-59-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11979/7/4/2/?documentUUID=f5b01d28-a55d-43a1-ac7e-2416f721b76b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/2541,PubChem,CCOc1nc2cccc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1,Train,1,2702,training
-"EU_REACH:
-methyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate",,139481-69-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18135/7/4/2/?documentUUID=5180bb1c-f0ea-41e5-b8fe-8e7d9d0c5e04,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/15654696,PubChem,CCOc1nc2cccc(C(=O)OC)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1,Train,1,2702,training
-"EU_REACH:
-1-[(2-tert-butylcyclohexyl)oxy]butan-2-ol",,139504-68-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11273/7/4/2/?documentUUID=182cf78a-9f8e-4399-b008-477a2b01fda6,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(COC1CCCCC1C(C)(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/164422,PubChem,CCC(O)COC1CCCCC1C(C)(C)C,Test,1,2702,training
-"JP_CHRIP:
-sec-Butylamine
-
-KR_NCIS:
-1-Methylpropylamine
-
-NZ_CCID:
-s-Butylamine","JP_CHRIP:
-1-Methyl propylamine
-1-methylpropylamine
-2-Aminobutane
-2-Butanamine
-
-KR_NCIS:
-(+)-(S)-sec-Butylamine; (+)-2-Aminobutane; (+)-2-Butylamine; (+)-sec-Butylamine; (+/-)-2-Butanamine; 1-Methylpropylamine; 2-Aminobutane; 2-Butanamine; 2-Butanamine, (2S)-; sec-Butylamine
-
-NZ_CCID:
-(RS)-sec-Butylamine, 1-Methylpropanamine, 1-Methylpropylamine, 2-AB, 2-Aminobutane, 2-Butanamine, 2-Butylamine, Butafume, Sec-butylamine, Tutane",13952-84-6,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0062e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0A694DC6-5774-458B-B162-946F4B872A60","JP_CHRIP:
-In the rabbit test, the substance was reported as a primary irritant (JMPR 320 (1975)), and the substance was classified as ""C; R35"" (EC-JRC (ESIS) (Access on Jul. 2010)). Based on these documents, the substance was classified as Category 1. As relevant notes, contact with human skin causes irritation or burns or dermatitis (HSDB (2008)).
-
-NZ_CCID:
-Skin Irritation
-UN CLASS: PG II
-
-Eye Irritation
-R PHRASE: R 35 [Company Data]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,CCC(C)N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J8.464F,J-GLOBAL,CCC(C)N,Train,1,2702,training
-"NZ_CCID:
-Diphenyl sulphide","NZ_CCID:
-phenyl sulfide",139-66-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B397C4B9-4378-4138-8D84-BBD8149143EF,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)SC2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/8766,PubChem,c1ccc(Sc2ccccc2)cc1,Train,1,2702,training
-"US_HSDB:
-SILDENAFIL",,139755-83-2,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/7305,,,US_HSDB,1,CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C,https://pubchem.ncbi.nlm.nih.gov/compound/135398744,PubChem,CCCc1nn(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(C)CC4)ccc3OCC)nc12,Train,1,2702,training
-"KR_NCIS:
-Nonylphenols","KR_NCIS:
-3-Nonylphenol; m-Nonylphenol; Phenol, 3-nonyl-; Phenol, m-nonyl-",139-84-4,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCCCCCCCCC1=CC(=CC=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/67320,PubChem,CCCCCCCCCc1cccc(O)c1,Train,1,2702,training
-"NZ_CCID:
-3,4-Dihydroxybenzaldehyde",,139-85-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9636324F-35CE-4FD6-B608-241AEE524B48,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C=C1C=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/8768,PubChem,O=Cc1ccc(O)c(O)c1,Train,1,2702,training
-"NZ_CCID:
-trans-2-Pentenoic acid",,13991-37-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2EDAA5D2-8714-429A-A47A-4DC4A9B7795B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC/C=C/C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/638122,PubChem,CC/C=C/C(=O)O,Train,1,2702,training
-"NZ_CCID:
-9-Octadecenoic acid, 12-(acetyloxy)-, butyl ester, (9Z,12R)-",,140-04-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/01F483AA-4A4D-42DB-A7EE-0C52A503BD1F,,,NZ_CCID,1,CCCCCC[C@H](C/C=C\CCCCCCCC(=O)OCCCC)OC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/5354171,PubChem,CCCCCC[C@H](C/C=C\CCCCCCCC(=O)OCCCC)OC(C)=O,Train,1,2702,training
-"NZ_CCID:
-2-Propenoic acid, 3-phenyl-, (E)-",,140-10-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CE413A80-D978-44C0-8F93-BB739B29F703,,,NZ_CCID,1,C1=CC=C(C=C1)/C=C/C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/444539,PubChem,O=C(O)/C=C/c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-Carbonic dihydrazide, 2,2'-diphenyl-",,140-22-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EFAF8912-E708-402D-B34A-80664AD9C9C0,,,NZ_CCID,1,C1=CC=C(C=C1)NNC(=O)NNC2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/8789,PubChem,O=C(NNc1ccccc1)NNc1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-2-piperazin-1-ylethylamine
-
-NZ_CCID:
-2-(1-Piperazinyl) ethylamine","JP_CHRIP:
-1-Aminoethylpiperazine
-1-Piperazineethanamine
-
-NZ_CCID:
-N-aminoethylpiperazine",140-31-8,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0194e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B7AD9C90-E8E2-428C-A8FD-E8EAB5FCC3FA","JP_CHRIP:
-In Draize tests using rabbits, the substance was reported to be corrosive and caused skin necrosis as a result of a 24-hour exposure (IUCLID, 2000). Furthermore, it is rated as R34 in the EU classification (EU-Annex 1, accessed in November 2008). Based on this information, the substance was classified into Category 1. According to HSDB (2002), it has human health effects such as strong irritations to the skin, eyes, and respiratory system.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,NCCN1CCNCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J35.446E,J-GLOBAL,NCCN1CCNCC1,Train,1,2702,training
-"EU_REACH:
-2-methylpentanedioic acid, dimethyl ester",,14035-94-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32878/7/4/2/?documentUUID=2a99981a-01e6-4203-93b2-4d1989a8a0fd,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CCC(=O)OC)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/118086,PubChem,COC(=O)CCC(C)C(=O)OC,Train,1,2702,training
-"NZ_CCID:
-4-Chlorobenzyl cyanide",,140-53-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B8C583DB-D670-4347-996E-26AE4A9173F2,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1CC#N)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/241582,PubChem,N#CCc1ccc(Cl)cc1,Train,1,2702,training
-"NZ_CCID:
-4-Fluorobenzylamine",,140-75-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DC57C65F-59A0-40FC-8433-A897C81CB60D,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1CN)F,https://pubchem.ncbi.nlm.nih.gov/compound/67326,PubChem,NCc1ccc(F)cc1,Train,1,2702,training
-"EU_REACH:
-6,6'-di-tert-butyl-4,4'-dimethoxy-[1,1'-biphenyl]-2,2'-diol",,14078-41-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11829/7/4/2/?documentUUID=aaf46a58-26b5-45cb-8113-d62ad2b4bbfb,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1=CC(=CC(=C1O)C2=C(C(=CC(=C2)OC)C(C)(C)C)O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/119234,PubChem,COc1cc(-c2cc(OC)cc(C(C)(C)C)c2O)c(O)c(C(C)(C)C)c1,Train,1,2702,training
-"JP_CHRIP:
-Pseudoionone",,141-10-6,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-0037e.html,"JP_CHRIP:
-It is reported in SIDS (2006) that in a skin irritation test with rabbits according to OECD TG 404, a skin irritation score after 72 hours was 2.9, and among erythema and edema that were observed, erythema disappeared within 15 days. Other than this, it is reported that in a sensitization test with guinea pigs according to OECD TG 406, irritation by this substance markedly occurred. Besides, it is reported that in a maximization test (concentration in petrolatum: 8%) in 108 volunteers, there was no irritation. Among the above information, based on the test according to TG 404, it was classified in Category 2.",Provided,JP_CHRIP,1,CC(=CCCC(=CC=CC(=O)C)C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.191F,J-GLOBAL,CC(=O)C=CC=C(C)CCC=C(C)C,Train,1,2702,training
-"EU_REACH:
-1,6-bis(2-butoxyethyl) hexanedioate",,141-18-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10353/7/4/2/?documentUUID=abb3b5ac-b8f9-4116-a3dd-cdc593505330,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOCCOC(=O)CCCCC(=O)OCCOCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/8837,PubChem,CCCCOCCOC(=O)CCCCC(=O)OCCOCCCC,Test,1,2702,training
-"AU_HCIS:
-n-butyl acrylate
-
-JP_CHRIP:
-n-Butyl acrylate
-
-NZ_CCID:
-2-Propenoic acid, butyl ester","AU_HCIS:
-2-Propenoic acid, butyl ester
-
-JP_CHRIP:
-2-Propenoic acid, butyl ester
-Acrylic acid n-butyl ester
-Butyl 2-propenoate
-butyl acrylate
-n-Butyl acrylate
-
-NZ_CCID:
-Acrylic acid n-butyl ester, Butyl 2-propenoate, Butyl acrylate, n-Butyl acrylate",141-32-2,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=710
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2002e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BA5475FD-ADBB-41FB-A8A8-ED7D4286F9EE","JP_CHRIP:
-There is a report that in a test in which rabbits were applied occlusively with the undiluted liquid of the test substance for 20 hours, erythema, edema and slight necrosis were observed after 24 hours, but these had almost disappeared after 8 days (SIDS (2004)). In addition, there is a report that in a test in which rabbits were applied occlusively with the undiluted liquid of the test substance, there was slight irritation (SIDS (2004), PATTY (6th, 2012), DFGOT vol. 5 (1993)). Based on the above results, it was classified in Category 2. Besides, this substance was classified as ""Xi; R36/R38"" in the EU DSD classification and as ""Skin. Irrit. 2 H315"" in the EU CLP classifications.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Irritating
-REFERENCE SOURCE: BASF AG Ludwigshafen TSCATS, Doc.I.D. 878212151, OTS 84003A, Celanese Chem Co Inc. (1972). [IUCLID 2000]
-
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Graded 3 on a scale of 1-10 (10 being the most severe).
-REFERENCE SOURCE: [Peer Reviewed] Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986. 102. [HSDB]
-R-PHRASE: R 36/37/38 Irritating to eyes, respiratory system and skin. [IUCLID 2000]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CCCCOC(=O)C=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.535F,J-GLOBAL,C=CC(=O)OCCCC,Train,1,2702,training
-"JP_CHRIP:
-2-Aminoethanol
-
-NZ_CCID:
-Ethanolamine
-
-US_HSDB:
-2-AMINOETHANOL","JP_CHRIP:
-2-aminoethanol
-2-Hydroxyethylamine
-Ethanol, 2-amino-
-
-NZ_CCID:
-1-Amino-2-hydroxyethane, 2-Amino-1-ethanol, 2-Aminoethanol, 2-Hydroxyethanamine, 2-Hydroxyethylamine, Aminoethanol, Colamine, Ethanol, 2-amino-, Ethylolamine, Glycinol, MEA, Monoethanolamine, Olamine",141-43-5,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2007e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EDA0F5DC-8E8F-4749-88D3-50FA800F82DA
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/531","JP_CHRIP:
-In a test in which the undiluted solution was applied to the skin of rabbits for 1 minute or 5 minutes and washed, bleeding and application time-dependent redness and necrosis were observed in the skin 1 day after application, and from 8 days after application, formation of desquamation was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). In addition, necrosis was observed at the site of application in the other two tests where the undiluted solution was applied to the skin of rabbits and in 1 study by application to the auricles of rabbits (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). Moreover, there is a report that redness and edema were observed in a 1.5-hour semi-occlusive dermal application test in human volunteers (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). From the above results, it was classified in Category 1A. Besides, this substance was classified as ""C; R34"" in the EU DSD classification, and as ""H314 Skin corr. 1B"" in the EU CLP classification.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rat, mouse, rabbit and dog
-RESULT: Liquid MEA is corrosive to the skin and eyes at high concentrations, and that at lower concentrations MEA is a skin and eye irritant.
-REFERENCE SOURCE: [Toxicology Unit, Health and Safety Executive, Bootle, UK]
-REMARK: C ? 25 % C; R20/21/22-34
-10 % ? C < 25 % C; R34
-5 % ? C < 10 % Xi; R36/37/38
-[ECB - Working db]
-Eye Irritation
-SPECIES: Rat, mouse, rabbit and dog
-RESULT: Liquid MEA is corrosive to the skin and eyes at high concentrations, and that at lower concentrations MEA is a skin and eye irritant.
-REFERENCE SOURCE: [Toxicology Unit, Health and Safety Executive, Bootle, UK]
-REMARK: C ? 25 % C; R20/21/22-34
-10 % ? C < 25 % C; R34
-5 % ? C < 10 % Xi; R36/37/38
-[ECB - Working db]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,NCCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.536D,J-GLOBAL,NCCO,Train,1,2702,training
-"EU_REACH:
-2,2,4,4,6,6,8,8-octamethyl-3,5,7-trioxa-2,4,6,8-tetrasilanonane",,141-62-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5665/7/4/2/?documentUUID=59495e3f-4b05-44ba-b8be-05b4d9067540,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/8852,PubChem,C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C,Train,1,2702,training
-"EU_REACH:
-4-(2-butyl-5-nitro-1-benzofuran-3-carbonyl)phenol",,141645-16-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6085/7/4/2/?documentUUID=85bef5f1-c38c-41b8-8d16-176f08e55289,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC1=C(C2=C(O1)C=CC(=C2)[N+](=O)[O-])C(=O)C3=CC=C(C=C3)O,https://pubchem.ncbi.nlm.nih.gov/compound/11473234,PubChem,CCCCc1oc2ccc([N+](=O)[O-])cc2c1C(=O)c1ccc(O)cc1,Train,1,2702,training
-"EU_CLP:
-(2-butyl-5-nitrobenzofuran-3-yl)[4-(3-dibutylaminopropoxy)phenyl]methanone",,141645-23-0,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCCCC1=C(C2=C(O1)C=CC(=C2)[N+](=O)[O-])C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/10209258,PubChem,CCCCc1oc2ccc([N+](=O)[O-])cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1,Test,1,2702,training
-"JP_CHRIP:
-Butyryl chloride
-
-NZ_CCID:
-Butyryl chloride
-
-US_HSDB:
-n-Butyryl chloride",,141-75-3,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0024e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A7341F9C-DD1D-42B9-A6CC-84C89212299D
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/6016","JP_CHRIP:
-Because there is the information that it is a strong irritant to tissue (HSDB (2003)) and it is classified in C; R34 in EU classification (EC-JRC (ESIS) (Access on Jan. 2011)), it was classified in Category 1.
-Besides, this substance is classified in class 3, subsidiary risk 8PGII in UNRTDG (UN2353).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,CCCC(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.538K,J-GLOBAL,CCCC(=O)Cl,Train,1,2702,training
-"EU_REACH:
-4-methylpent-3-en-2-one
-
-JP_CHRIP:
-Mesityloxid (Mesityl oxide)","JP_CHRIP:
-4-Methyl-3-penten-2-one
-Methyl isobutenyl ketone",141-79-7,Cat 2,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2148/7/4/2/?documentUUID=8306bf98-6d3e-4105-be56-ef004dba5895
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2112e.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-There are reports that marked irritation occurred when 0.5 mL of this substance was applied to mice (PATTY (6th, 2012)), and that mild irritation was produced in a test in which 430 mg of this substance was applied to rabbits (PATTY (6th, 2012)). In addition, there is a description that the liquid phase of this substance is an irritant (HSDB (Access on September 2014)). From the above, based on the result of ""marked irritation,"" it was classified in Category 2.",Provided,"EU_REACH, JP_CHRIP",2,CC(=CC(=O)C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.540B,J-GLOBAL,CC(=O)C=C(C)C,Train,1,2702,training
-"NZ_CCID:
-2,6-Diaminopyridine",,141-86-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A8702FD1-9040-4C01-B886-836C8584F599,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=NC(=C1)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/8861,PubChem,Nc1cccc(N)n1,Train,1,2702,training
-"AU_HCIS:
-5-Pyrimidinamine, 1,3-bis(2-ethylhexyl)hexahydro-5-methyl-
-
-NZ_CCID:
-Hexetidine","NZ_CCID:
-5-Pyrimidinamine, 1,3-bis(2-ethylhexyl)hexahydro-5-methyl-, Glypesin, Sterilate, Sterisil, oraldene",141-94-6,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5518
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/16131C01-05AF-4F3E-9687-0D4C765A80BC","NZ_CCID:
-Skin Irritation
-SPECIES:
-RESULT: Moderate
-REFERENCE SOURCE: http://www.fda.gov/ohrms/dockets/ac/98/transcpt/3425t1.rtf
-Eye Irritation
-SPECIES:
-RESULT: Corrosive
-REFERENCE SOURCE: http://www.fda.gov/ohrms/dockets/ac/98/transcpt/3425t1.rtf",,"AU_HCIS, NZ_CCID",2,CCCCC(CC)CN1CC(CN(C1)CC(CC)CCCC)(C)N,https://pubchem.ncbi.nlm.nih.gov/compound/3607,PubChem,CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1,Train,1,2702,training
-"JP_CHRIP:
-Ethyl acetoacetate","JP_CHRIP:
-1-Ethoxybutane-1,3-dione
-3-Oxobutanoic acid ethyl ester
-Acetoacetic acid ethyl ester
-Ethyl acetylacetate",141-97-9,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0061e.html,"JP_CHRIP:
-The substance was classified as ""Not classified"" based on the documented case of ""not irritating"" resulted from rabbit test (OECD TG 404, GLP-compliant) in which 0.5 mL of test substance was applied for 4 hours (EU-RAR 13 (2002), IUCLID (2000)).",Provided,JP_CHRIP,1,CCOC(=O)CC(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.493H,J-GLOBAL,CCOC(=O)CC(C)=O,Train,1,2702,training
-"AU_HCIS:
-Carbamothioic acid, ethyl-, O-(1-methylethyl) ester",,141-98-0,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5425,,,AU_HCIS,1,CCNC(=S)OC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/3032295,PubChem,CCNC(=S)OC(C)C,Train,1,2702,training
-"EU_REACH:
-2-chloro-3-isothiocyanatoprop-1-ene",,14214-31-4,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1088/7/4/2/?documentUUID=0533af7b-0f54-430d-9c04-6bfe0396e723,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=C(CN=C=S)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/26575,PubChem,C=C(Cl)CN=C=S,Test,1,2702,training
-"EU_REACH:
-bis(2-ethylhexyl) but-2-enedioate
-
-JP_CHRIP:
-Bis(2-ethylhexan-1-yl) maleate",,142-16-5,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14675/7/4/2/?documentUUID=460fe4dd-a371-4e35-975e-2a9abfca8c16
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0003e.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-[Rationale for the Classification]
-It was classified as ""Not classified"" (Category 3 in UN GHS classification) from (1).
-
-[Evidence Data]
-(1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 13-day observation), erythema and edema completely disappeared within 10 days, and slight irritation was seen (erythema/eschar score: 2/2/2, edema score: 1.3/1.3/1.3) (REACH registration dossier (Accessed May 2020)).",Provided,"EU_REACH, JP_CHRIP",2,CCCCC(CC)COC(=O)/C=C\C(=O)OCC(CC)CCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J36.805I,J-GLOBAL,CCCCC(CC)COC(=O)/C=C\C(=O)OCC(CC)CCCC,Train,1,2702,training
-"JP_CHRIP:
-Diethylene glycol bis(allyl carbonate)","JP_CHRIP:
-2,2'-oxydiethyl bis(allyl carbonate)
-diethylene glycolbis(allyl carbonate)",142-22-3,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0142e.html,"JP_CHRIP:
-In occupational exposure, a 19-year-old woman who was employed to inject diallylgycol carbonate liquid monomer into lens molds developed contact dermatitis. During work, spilled monomer occasionally splashed on her hands and arms. After 2 weeks, the patient developed blisters and edema of the back of her hands, forearms and knees, and was hospitalized (HSDB (2002)). By subsequent patch test carried out in ten volunteers with 1% solution of the substance, the irritant nature of the product was confirmed since minimal or mild edema were observed (HSDB (2002)). In addition to the conclusion that the case mentioned above showed an allergic contact dermatitis by the substance, there was the description that the substance was also skin irritant (HSDB (2002)). Based on these documents, the substance was classified as Category 2. As relevant notes, non irritating result was reported in the rabbit test (IUCLID (2000)), and severe result was also reported in the datum from the ""List 3"" information source designated in the GHS classification guidance for the Japanese government (RTECS (2010)).",,JP_CHRIP,1,C=CCOC(=O)OCCOCCOC(=O)OCC=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J56.135E,J-GLOBAL,C=CCOC(=O)OCCOCCOC(=O)OCC=C,Train,1,2702,training
-"JP_CHRIP:
-1,3-Dichloropropane","JP_CHRIP:
-Propane, 1,3-dichloro-",142-28-9,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0189e.html,"JP_CHRIP:
-It was reported that the substance was irritating to the skin (HSDB (2002)). In human cases, exposure of the substance caused severe skin irritation with marked inflammatory response in the epidermal and subcutaneous tissues (HSDB (2002)). Based on the information, the substance was classified as Category 2.",,JP_CHRIP,1,ClCCCCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.543G,J-GLOBAL,ClCCCCl,Train,1,2702,training
-"EU_REACH:
-N-(1-oxooctyl)glycine",,14246-53-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11322/7/4/2/?documentUUID=d6fae830-5174-4b16-9cdd-c04ccf1cc63d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCC(=O)NCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/84290,PubChem,CCCCCCCC(=O)NCC(=O)O,Test,1,2702,training
-"NZ_CCID:
-Hexanoyl chloride","NZ_CCID:
-caproyl chloride",142-61-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/71C35BD9-02E5-4A04-942F-5C0F5F86D3D7,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/67340,PubChem,CCCCCC(=O)Cl,Train,1,2702,training
-"JP_CHRIP:
-Hexanoic acid
-
-NZ_CCID:
-Hexanoic acid","JP_CHRIP:
-Butylacetic acid
-Capronic acid
-n-Caproic acid",142-62-1,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0075e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A8127B28-67CC-4A2F-AEC0-CA827FDB3D19","JP_CHRIP:
-Based on results that necrosis was followed by scar formation with the scars persisting for 21 days after application in a rabbit test (OECD TG404 (GLP)) (BUA 241 (2002)), the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",Provided,"JP_CHRIP, NZ_CCID",2,CCCCCC(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.546A,J-GLOBAL,CCCCCC(=O)O,Train,1,2702,training
-"JP_CHRIP:
-n-Heptane","JP_CHRIP:
-n-Heptane",142-82-5,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2088e.html,"JP_CHRIP:
-In humans, since there is a report that irritation and dermatitis were observed after 1-hour contact (DFGOT vol. 11 (1998)) and there is a description that direct skin contact caused pain, burn and pruritus (OEL Documentations (Japan Society for Occupational Health (JSOH), 1988)), this substance was classified in Category 2. Besides, this substance was classified in ""Xi; R38"" in the EU DSD classification and in ""Skin Irrit. 2 H315"" in the EU CLP classification.",,JP_CHRIP,1,CCCCCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.027C,J-GLOBAL,CCCCCCC,Train,1,2702,training
-"JP_CHRIP:
-2,4-Hexadienal",,142-83-6,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0003e.html,"JP_CHRIP:
-In a test in which 0.5 mL of the undiluted test substance was applied to the rabbit skin for 4 hours, 4 out of 4 animals showed severe edema immediately after application and severe erythema 2-3 days after application, and the skin hardened and was stained brown. Furthermore, the treated skin was pitted on day 7 in two animals, and the primary skin irritation index was 7.08 (ECETOC TR66 (1995)). Therefore, it was classified in Category 1.",,JP_CHRIP,1,C/C=C/C=C/C=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J12.975E,J-GLOBAL,C/C=C/C=C/C=O,Train,1,2702,training
-"AU_HCIS:
-dipropylamine
-
-JP_CHRIP:
-Di-n-propylamine
-
-NZ_CCID:
-1-Propanamine, N-propyl-","AU_HCIS:
-1-Propanamine, N-propyl-
-
-NZ_CCID:
-Dipropylamine, N-Propyl-1-propanamine, n-Dipropylamine",142-84-7,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1601
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2020e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B7616E4F-5F19-4536-B1BB-ECC1766C265A","JP_CHRIP:
-[Rationale for the Classification]
-Based on (1) and (2), it was classified in Category 1A. Besides, the category was changed from the previous classification by using new information sources.
-
-[Evidence Data]
-(1) In a GLP-compliant study in which rabbits were divided into 4 groups (n=3) and exposed to 0.5 mL of this substance by patch for one minute, necrosis with erythema was observed in one or more animals 1 hour after application in the group in which the skin was wiped with dry gauze, in the group in which the skin was washed with distilled water, and in the group in which the skin was swabbed with PEG 300 after washing with distilled water (NICNAS IMAP (Accessed Jul. 2018), REACH registration dossier (Accessed Sept. 2018), HSDB (2014)).
-(2) There is a report that in a Draize test with rabbits (n=3), erythema and edema were observed after a 3-minute application, and this did not resolve after 7 days (REACH registration dossier (Accessed Sept. 2018)).
-
-[Reference Data, etc.]
-(3) In a Draize test or a test similar to OECD TG404 with rabbits, aliphatic secondary amines are known to be corrosive to the skin (SIAP (2013))
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Highly corrosive
-REFERENCE SOURCE: BASF AG Ludwigshafen
-(42) BASF Aktiengesellschaft, unveroeffentlichte Untersuchung (XIX/320) 30.12.1969. [IUCLID 2000]
-REMARK: EC Classification: Highly corrosive (causes severe burns).
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Irritating
-REFERENCE SOURCE: BASF AG Ludwigshafen
-(42) BASF Aktiengesellschaft, unveroeffentlichte Untersuchung (XIX/320) 30.12.1967
-[IUCLID 2000]
-REMARK: EC Classification: Risk of serious damage to eyes.",Provided,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CCCNCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.547J,J-GLOBAL,CCCNCCC,Train,1,2702,training
-"EU_CLP:
-(2,3-dimethylbut-2-yl)-trimethoxysilane",,142877-45-0,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C)C(C)(C)[Si](OC)(OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/22035356,PubChem,CO[Si](OC)(OC)C(C)(C)C(C)C,Test,1,2702,training
-"ChemSkin:
-Isopropyl palmitate
-
-EU_REACH:
-propan-2-yl hexadecanoate",,142-91-6,NC,"ChemSkin: https://doi.org/10.3390/toxics9110314
-EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15814/7/4/2/?documentUUID=e11fe757-ca7c-4ce1-995f-656f3e4617c9","ChemSkin:
-Experimental study (OECD TG 404)
-
-EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,"ChemSkin, EU_REACH",2,CCCCCCCCCCCCCCCC(=O)OC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/8907,PubChem,CCCCCCCCCCCCCCCC(=O)OC(C)C,Train,1,2702,training
-"JP_CHRIP:
-Hexyl acetate
-
-NZ_CCID:
-Hexyl acetate","JP_CHRIP:
-Hexyl acetate
-
-NZ_CCID:
-n-Hexyl ethanoate",142-92-7,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0084e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0D3800BD-8082-4AEE-8AC1-30840D7B5361","JP_CHRIP:
-Based on a report of ""moderate irritation"" for rabbits (PATTY (5th, 2001) and a report that there appears to be some absorption from skin but direct application to skin causes only ""moderate irritation"" (HSDB (2002)), the substance was classified into Category 2.
-
-NZ_CCID:
-Skin Irritation
-REMARK: Animals tolerate relatively large doses both by mouth & by inhalation of vapor. There appears to be some absorption from skin but direct application to skin and eyes causes only moderate irritation.
-REFERENCE SOURCE:[Browning, E. Toxicity and Metabolism of Industrial Solvents. New York: American Elsevier, 1965., p. 545]**PEER REVIEWED**
-Eye Irritation
-REMARK: Animals tolerate relatively large doses both by mouth & by inhalation of vapor. There appears to be some absorption from skin but direct application to skin and eyes causes only moderate irritation.
-REFERENCE SOURCE:[Browning, E. Toxicity and Metabolism of Industrial Solvents. New York: American Elsevier, 1965., p. 545]**PEER REVIEWED**",,"JP_CHRIP, NZ_CCID",2,CCCCCCOC(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.028A,J-GLOBAL,CCCCCCOC(C)=O,Train,1,2702,training
-"ChemSkin:
-Dodecanoic acid (lauric acid)
-
-EU_REACH:
-dodecanoic acid",,143-07-7,NC,"ChemSkin: https://doi.org/10.3390/toxics9110314
-EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15262/7/4/2/?documentUUID=cf62d791-1fcf-4912-b7fd-48b66285b3f7","ChemSkin:
-Experimental study (OECD TG 404)
-
-EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,"ChemSkin, EU_REACH",2,CCCCCCCCCCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/3893,PubChem,CCCCCCCCCCCC(=O)O,Train,1,2702,training
-"NZ_CCID:
-Dihexylamine",,143-16-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F061F262-F8F5-4FFF-B9E4-67DA21994277,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCCNCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/8920,PubChem,CCCCCCNCCCCCC,Train,1,2702,training
-"EU_REACH:
-2,5,8,11,14-pentaoxapentadecane",,143-24-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14547/7/4/2/?documentUUID=e24f12fb-e08a-49c4-afd6-cf00024f2ef3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COCCOCCOCCOCCOC,https://pubchem.ncbi.nlm.nih.gov/compound/8925,PubChem,COCCOCCOCCOCCOC,Train,1,2702,training
-"EU_REACH:
-methyl 2-[(4-hydroxybenzenesulfonyl)oxy]benzoate",,1432505-97-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6300/7/4/2/?documentUUID=dbb0fb72-12c8-457a-b94e-2812666d993d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=CC=CC=C1OS(=O)(=O)C2=CC=C(C=C2)O,https://pubchem.ncbi.nlm.nih.gov/compound/102494927,PubChem,COC(=O)c1ccccc1OS(=O)(=O)c1ccc(O)cc1,Train,1,2702,training
-"AU_HCIS:
-1-Hexadecanamine
-
-NZ_CCID:
-Hexadecylamine","NZ_CCID:
-1-hexadecylamine",143-27-1,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4990
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F98A6C94-D15B-4261-8AF7-572D7B39149F","NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"AU_HCIS, NZ_CCID",2,CCCCCCCCCCCCCCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/8926,PubChem,CCCCCCCCCCCCCCCCN,Train,1,2702,training
-"NZ_CCID:
-Oleyl alcohol, >50% in a non hazardous diluent",,143-28-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B3B7E0DE-EFFF-4639-A29B-5FFACB51ADEC,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]",,NZ_CCID,1,CCCCCCCC/C=C\CCCCCCCCO,https://pubchem.ncbi.nlm.nih.gov/compound/5284499,PubChem,CCCCCCCC/C=C\CCCCCCCCO,Train,1,2702,training
-"EU_REACH:
-5,8,11,13,16,19-hexaoxatricosane",,143-29-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13599/7/4/2/?documentUUID=d149c6fd-4741-47c8-805d-16523793dd69,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOCCOCCOCOCCOCCOCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/8928,PubChem,CCCCOCCOCCOCOCCOCCOCCCC,Train,1,2702,training
-"EU_CLP:
-ethyl 2-carboxy-3-(2-thienyl)propionate",,143468-96-6,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCOC(=O)C(CC1=CC=CS1)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/14952883,PubChem,CCOC(=O)C(Cc1cccs1)C(=O)O,Test,1,2702,training
-"EU_CLP:
-1,3-dichloro-4-fluorobenzene",,1435-48-9,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC(=C(C=C1Cl)Cl)F,https://pubchem.ncbi.nlm.nih.gov/compound/123112,PubChem,Fc1ccc(Cl)cc1Cl,Test,1,2702,training
-"EU_REACH:
-4-methyl-2-[(2-nitrophenyl)diazenyl]phenol",,1435-71-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1573/7/4/2/?documentUUID=3c6e1daa-ab5e-4130-83c5-2edb261414b5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)O)N=NC2=CC=CC=C2[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/74029,PubChem,Cc1ccc(O)c(N=Nc2ccccc2[N+](=O)[O-])c1,Train,1,2702,training
-"EU_REACH:
-Glycerol, ethoxylated, esters with acrylic acid",,144086-03-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12378/7/4/2/?documentUUID=10e37b6e-9eca-4d54-8972-94b622101eb8,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(C(CO)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/753,PubChem,OCC(O)CO,Train,1,2702,training
-"EU_REACH:
-1,2,3-tris(2-ethylhexyl) 2-(acetyloxy)propane-1,2,3-tricarboxylate",,144-15-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6763/7/4/2/?documentUUID=1375e3b7-4c1d-4864-9ecc-226d90e5b336,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)CC(CC(=O)OCC(CC)CCCC)(C(=O)OCC(CC)CCCC)OC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/101632,PubChem,CCCCC(CC)COC(=O)CC(CC(=O)OCC(CC)CCCC)(OC(C)=O)C(=O)OCC(CC)CCCC,Train,1,2702,training
-"EU_REACH:
-N,N-dimethyldecanamide
-
-NZ_CCID:
-Decanamide, N,N-dimethyl-","NZ_CCID:
-Agnique AMD 10, N,N-Dimethyldecanamide",14433-76-2,Cat 2,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15021/7/4/2/?documentUUID=51d4cc19-612c-41d4-84dc-769aa11a523e
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FE31CDD9-D6FB-4F24-A9AF-3DAC827BA1F1","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: The results of a DOT corrosivity potential study performed in 6 rabbits indicate that Hallcomid M-8-10 causes moderate-severe
-
-Skin Irritation but is not corrosive (Harris, 1990). An additional
-
-Skin Irritation study performed in one rabbit indicates that the material is corrosive (Kreuzmarm, 1990b). Altogether, these results suggest that Hallcomid M-8-10 is severely irritating to the skin.
-REFERENCE SOURCE: (Test Plan for N,N-dimethyloctanamide and N,N-dimethyldecanamide 12-16-02) [HPV]
-
-Eye Irritation: Decanamide, N,N-dimethyl- (CAS number 14433-76-2) should be classified as an Eye irritant Category 2 following principles of GHS v7.0. We can ignore the flag. In this study, moderate to severe signs of eye irritation were observed in rabbits. The study was performed following OECD TG 405 with GLP compliance and is reliable (KL1). While updating the classification you can also give the Mean Draize scores which trigger the classification:
-
-Mean Draize Score (24, 48 and 72 hrs)
-
-Cornea opacity 1.0
-
-Iris lesion 0.0
-
-Redness of conjunctiva 2.6
-
-Oedema of conjunctiva 2.8
-
-SPECIES: Rabbit
-RESULT: Moderate to severe signs of irritation
-REFERENCE SOURCE: ECHA study data",Provided,"EU_REACH, NZ_CCID",2,CCCCCCCCCC(=O)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/26690,PubChem,CCCCCCCCCC(=O)N(C)C,Train,1,2702,training
-"EU_REACH:
-3-(3,5-di-tert-butyl-4-hydroxyphenyl)-N-octadecylpropanamide",,14442-94-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7426/7/4/2/?documentUUID=60d922fb-2010-4b61-8593-a1b3ad0c3146,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCCCNC(=O)CCC1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/19736307,PubChem,CCCCCCCCCCCCCCCCCCNC(=O)CCc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1,Train,1,2702,training
-"EU_REACH:
-Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, 2-ethylhexyl ester",,144429-84-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/28295/7/4/2/?documentUUID=a663392f-8ad3-48f2-a825-5d2e0506083e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)CCC1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11486113,PubChem,CCCCC(CC)COC(=O)CCc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1,Train,1,2702,training
-"NZ_CCID:
-2-Iodoacetamide","NZ_CCID:
-iodoacetamide",144-48-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/56E6D51A-73B2-4D57-A60A-D526399E4FFF,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(C(=O)N)I,https://pubchem.ncbi.nlm.nih.gov/compound/3727,PubChem,NC(=O)CI,Train,1,2702,training
-"JP_CHRIP:
-Fluoroacetic acid
-
-US_HSDB:
-Fluoroacetic acid","JP_CHRIP:
-alpha-Fluoroacetic acid
-FAA
-Monofluoroacetic acid",144-49-0,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2090e.html
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/2082","JP_CHRIP:
-[Rationale for the Classification]
-Based on (1) and (2), it was classified in Category 1.
-
-[Evidence Data]
-(1) Following contact with the skin, burning sensation, reddening, severe irritation, and painful tissue damage may occur. The extent of these symptoms is assumed to be dependent on the concentration and duration of exposure (GESTIS (Access on September 2019)).
-(2) This substance is irritating (HSDB (Access on September 2019)).",,"JP_CHRIP, US_HSDB",2,OC(=O)CF,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.550J,J-GLOBAL,O=C(O)CF,Train,1,2702,training
-"NZ_CCID:
-Trimethyl orthoacetate",,1445-45-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3FA9612D-7147-40CF-8606-69409C9029FA,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CC(OC)(OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/15050,PubChem,COC(C)(OC)OC,Train,1,2702,training
-"EU_REACH:
-2-{2,2,6,6-tetramethyl-4-[(3,5,5-trimethylhexanoyl)oxy]piperidin-1-yl}ethyl 3,5,5-trimethylhexanoate",,1445870-18-7,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11561/7/4/2/?documentUUID=670fb28b-308b-4159-8c1f-cc05d8861c6f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CC(=O)OCCN1C(CC(CC1(C)C)OC(=O)CC(C)CC(C)(C)C)(C)C)CC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/117799809,PubChem,CC(CC(=O)OCCN1C(C)(C)CC(OC(=O)CC(C)CC(C)(C)C)CC1(C)C)CC(C)(C)C,Train,1,2702,training
-"EU_REACH:
-4'-{[4-methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}-[1,1'-biphenyl]-2-carbonitrile",,144702-27-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7768/7/4/2/?documentUUID=4d85316f-51d5-4c76-bc7b-2b1e77c2b6ec,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1=NC2=C(N1CC3=CC=C(C=C3)C4=CC=CC=C4C#N)C=C(C=C2C)C5=NC6=CC=CC=C6N5C,https://pubchem.ncbi.nlm.nih.gov/compound/11961510,PubChem,CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C#N)cc1,Train,1,2702,training
-"EU_REACH:
-3-[dimethoxy(methyl)silyl]propyl methacrylate",,14513-34-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24122/7/4/2/?documentUUID=e16a510c-a069-43e6-b411-6dec002e7e82,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OCCC[Si](C)(OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/84485,PubChem,C=C(C)C(=O)OCCC[Si](C)(OC)OC,Train,1,2702,training
-"AU_HCIS:
-Methanol, (phenylmethoxy)-",,14548-60-8,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5042,,,AU_HCIS,1,C1=CC=C(C=C1)COCO,https://pubchem.ncbi.nlm.nih.gov/compound/84520,PubChem,OCOCc1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-endothal
-
-KR_NCIS:
-Endothal","KR_NCIS:
-1,2-Benzenedicarboxylic acid, hexahydro-3,6-endo-oxy-; 1,2-Cyclohexanedicarboxylic acid, 3,6-endo-epoxy-; 3,6-Endo-epoxy-1,2-cyclohexanedicarboxylic acid; 3,6-Endooxohexahydrophthalic acid; 3,6-Endooxyphthalic acid, hexahydro-; 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid; Hexahydro-3,6-endo-oxy-1,2-benzenedicarboxylic acid; Hexahydro-3,6-endooxyphthalic acid",145-73-3,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-1136e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP:
-Since severe irritation was indicated to skin of rabbits as a result of the skin irritation study using a rabbit (Agricultural Chemical Registration Data (1994)), it was set as Category 2.",,"JP_CHRIP, KR_NCIS",2,OC(=O)C1C2CCC(O2)C1C(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.834C,J-GLOBAL,O=C(O)C1C2CCC(O2)C1C(=O)O,Train,1,2702,training
-"KR_NCIS:
-3-Bromo-2-methyl-1-propene",,1458-98-6,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CC(=C)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/357785,PubChem,C=C(C)CBr,Train,1,2702,training
-"EU_REACH:
-1,3-dimethyl benzene-1,3-dicarboxylate",,1459-93-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5958/7/4/2/?documentUUID=e3b922cd-7f85-4925-9f8d-87d4a63cc448,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=CC(=CC=C1)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/15088,PubChem,COC(=O)c1cccc(C(=O)OC)c1,Train,1,2702,training
-"JP_CHRIP:
-1,3-Butadiene diepoxide",,1464-53-5,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/07-mhlw-0094e.html,"JP_CHRIP:
-Based on the reports that it causes severe skin irritation (HSDB, 2003; RTECS, accessed in October 2007) and that coming into contact with it can irritate and burn the skin (HSFS, 2000), the substance was classified into Category 2.",,JP_CHRIP,1,C1OC1C1CO1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.668D,J-GLOBAL,C1OC1C1CO1,Train,1,2702,training
-"NZ_CCID:
-(S)-(-)-1-Phenylethyl isocyanate",,14649-03-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/ED12E1A7-22AA-45C9-872D-08F73EA44534,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C[C@@H](C1=CC=CC=C1)N=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/2724173,PubChem,C[C@H](N=C=O)c1ccccc1,Train,1,2702,training
-"EU_REACH:
-4-hydroxy-2-methylpentan-2-yl 2-ethyl-2-methylheptaneperoxoate",,1467668-33-2,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5032/7/4/2/?documentUUID=a6045159-0b01-4160-b8f1-20f3525b6611,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCC(C)(CC)C(=O)OOC(C)(C)CC(C)O,https://pubchem.ncbi.nlm.nih.gov/compound/60208746,PubChem,CCCCCC(C)(CC)C(=O)OOC(C)(C)CC(C)O,Train,1,2702,training
-"NZ_CCID:
-Isopentanoic anhydride",,1468-39-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1187330D-651B-41EB-82D3-0F71BFBE1F72,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)CC(=O)OC(=O)CC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/73847,PubChem,CC(C)CC(=O)OC(=O)CC(C)C,Train,1,2702,training
-"NZ_CCID:
-Tempace","NZ_CCID:
-4-acetamido-TEMPO",14691-89-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CCC2EF1A-5FC2-4AF2-B84A-EA0A73EA0A65,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(=O)NC1CC(C)(C)N([O])C(C)(C)C1,https://cactus.nci.nih.gov/chemical/structure/14691-89-5/smiles,CACTUS,CC(=O)NC1CC(C)(C)N([O])C(C)(C)C1,Train,1,2702,training
-"EU_REACH:
-Biphenyl-4,4'-diyl tetrakis(2,6-dimethylphenyl) bis(phosphate)",,147263-99-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6661/7/4/2/?documentUUID=f95aa7b0-ce0c-428b-a7e7-288ae16d74bd,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(=CC=C1)C)OP(=O)(OC2=CC=C(C=C2)C3=CC=C(C=C3)OP(=O)(OC4=C(C=CC=C4C)C)OC5=C(C=CC=C5C)C)OC6=C(C=CC=C6C)C,https://pubchem.ncbi.nlm.nih.gov/compound/59749758,PubChem,Cc1cccc(C)c1OP(=O)(Oc1ccc(-c2ccc(OP(=O)(Oc3c(C)cccc3C)Oc3c(C)cccc3C)cc2)cc1)Oc1c(C)cccc1C,Train,1,2702,training
-"AU_HCIS:
-9-Octadecen-1-amine, N,N-dimethyl-, (Z)-",,14727-68-5,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5655,,,AU_HCIS,1,CCCCCCCC/C=C\CCCCCCCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/5357010,PubChem,CCCCCCCC/C=C\CCCCCCCCN(C)C,Train,1,2702,training
-"EU_REACH:
-2-(4,6-diphenyl-1,3,5-triazin-2-yl)-5-(hexyloxy)phenol",,147315-50-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8654/7/4/2/?documentUUID=7f392510-0fd8-4ba0-8c65-96048ecbbea1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCOC1=CC(=C(C=C1)C2=NC(=NC(=N2)C3=CC=CC=C3)C4=CC=CC=C4)O,https://pubchem.ncbi.nlm.nih.gov/compound/4992761,PubChem,CCCCCCOc1ccc(-c2nc(-c3ccccc3)nc(-c3ccccc3)n2)c(O)c1,Train,1,2702,training
-"NZ_CCID:
-3-Hydroxycinnamic acid",,14755-02-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E2F766A7-E2E2-4B13-8CAE-E059EAA08CD0,,,NZ_CCID,1,C1=CC(=CC(=C1)O)/C=C/C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/637541,PubChem,O=C(O)/C=C/c1cccc(O)c1,Train,1,2702,training
-"EU_REACH:
-4-[4-trans-(3,4-Difluorophenyl)-cyclohexyl]-cyclohexanone",,147622-85-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23736/7/4/2/?documentUUID=c680dcf7-f154-4efd-8efd-66415afbf721,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC(CCC1C2CCC(=O)CC2)C3=CC(=C(C=C3)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/11493045,PubChem,O=C1CCC(C2CCC(c3ccc(F)c(F)c3)CC2)CC1,Train,1,2702,training
-"JP_CHRIP:
-m-Xylylenediamine","JP_CHRIP:
-1,3-Benzenedimethanamine
-1,3-bis(aminomethyl)benzene
-1,3-bis-Aminomethylbenzene
-m-phenylenebis(methylamine)
-m-Xylene alpha, alpha'-diamine
-m-Xylylenediamine",1477-55-0,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2009e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified in Category 1 from (1), (2).
-
-[Evidence Data]
-(1) Undiluted this substance was corrosive to the guinea pig skin, and a 50% emulsion in acetone/dioxane was severely irritating, but a 10% emulsion produced little effect. And a topical application of a 10% aqueous solution caused severe erythema and edema (ACGIH (7th, 2019)).
-(2) This substance is corrosive to the rat and mouse skin (SIAP (2001), REACH registration dossier (Access on May 2020)).",,JP_CHRIP,1,NCc1cccc(CN)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J38.174H,J-GLOBAL,NCc1cccc(CN)c1,Train,1,2702,training
-"EU_REACH:
-4-[1,1,1,3,3,3-hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenol",,1478-61-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23236/7/4/2/?documentUUID=59817356-3052-4985-9e44-a81581bfa9d4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1C(C2=CC=C(C=C2)O)(C(F)(F)F)C(F)(F)F)O,https://pubchem.ncbi.nlm.nih.gov/compound/73864,PubChem,Oc1ccc(C(c2ccc(O)cc2)(C(F)(F)F)C(F)(F)F)cc1,Train,1,2702,training
-"NZ_CCID:
-Thiosalicylic acid",,147-93-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AA79C76F-3BA1-4C7A-8BDA-7C2976F86D0A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)C(=O)O)S,https://pubchem.ncbi.nlm.nih.gov/compound/5443,PubChem,O=C(O)c1ccccc1S,Train,1,2702,training
-"JP_CHRIP:
-dinitolmide
-
-NZ_CCID:
-Dinitro-o-toluamide","JP_CHRIP:
-2-Methyl-3,5-dinitrobenzamide
-3,5-Dinitro-2-methylbenzamide
-
-NZ_CCID:
-2-Methyl-3,5-dinitrobenzamide, 3,5-Dinitro-o-toluamide, Benzamide, 2-methyl-3,5-dinitro-, Dinitolmide, o-Toluamide, 3,5-dinitro-",148-01-6,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0969e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/02E9C280-CAC3-411A-941C-51212A8BABF0","JP_CHRIP:
-Since contact eczema was acknowledged in human occupation evidence of exposure, and from description that it was a skin test positivity (ACGIH (7th, 2001)), it was judged that it was skin irritation and it was set as Category 2.
-
-NZ_CCID:
-Skin Irritation
-SPECIES:
-RESULT: A low to moderate order of toxicity with
-Skin Irritation.
-REFERENCE SOURCE: Documentation of the threshold limit values and biological exposure indices PG:2 p YR:2001 IP: VI:7 th Ed [TOXLINE]
-
-Eye Irritation
-EXPERT JUDGEMENT: As it is a skin irritant, it is expected to cause
-Eye Irritation also.",,"JP_CHRIP, NZ_CCID",2,Cc1c(cc(cc1[N+](=O)[O-])[N+](=O)[O-])C(=O)N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.959I,J-GLOBAL,Cc1c(C(N)=O)cc([N+](=O)[O-])cc1[N+](=O)[O-],Train,1,2702,training
-"EU_REACH:
-1,12-bis({2-[4-(4,6-diphenyl-1,3,5-triazin-2-yl)-3-hydroxyphenoxy]ethyl}) dodecanedioate",,1482217-03-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7675/7/4/2/?documentUUID=d2fc4280-abde-44f8-a035-ba6bdd459e1b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C2=NC(=NC(=N2)C3=C(C=C(C=C3)OCCOC(=O)CCCCCCCCCCC(=O)OCCOC4=CC(=C(C=C4)C5=NC(=NC(=N5)C6=CC=CC=C6)C7=CC=CC=C7)O)O)C8=CC=CC=C8,https://pubchem.ncbi.nlm.nih.gov/compound/136798548,PubChem,O=C(CCCCCCCCCCC(=O)OCCOc1ccc(-c2nc(-c3ccccc3)nc(-c3ccccc3)n2)c(O)c1)OCCOc1ccc(-c2nc(-c3ccccc3)nc(-c3ccccc3)n2)c(O)c1,Train,1,2702,training
-"EU_REACH:
-3-(2,4-dichlorophenyl)-2-oxo-1-oxaspiro[4.5]dec-3-en-4-yl 2,2-dimethylbutanoate
-
-JP_CHRIP:
-3-(2,4-Dichlorophenyl)-2-oxo-1-oxaspiro[4.5]dec-3-en-4-yl 2,2-dimethylbutanoate; Spirodiclofen",,148477-71-8,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32995/7/4/2/?documentUUID=3c556745-0514-4711-a027-3853ca382768
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0053e.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-[Rationale for the Classification]
-It was classified as ""Not classified"" from (1).
-
-[Evidence Data]
-(1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 72-hour observation), no skin irritation changes were seen (erythema/eschar score: 0/0/0, edema score: 0/0/0) (ECHA RAC Opinion (2016), CLH Report (2015), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)).",Provided,"EU_REACH, JP_CHRIP",2,CCC(C)(C)C(=O)OC1=C(C(=O)OC21CCCCC2)c1ccc(Cl)cc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.571.716E,J-GLOBAL,CCC(C)(C)C(=O)OC1=C(c2ccc(Cl)cc2Cl)C(=O)OC12CCCCC2,Train,1,2702,training
-"EU_REACH:
-bis(2-ethylhexyl) carbonate",,14858-73-2,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11038/7/4/2/?documentUUID=0a90b8ef-02ad-46da-a7e9-37e7f7fbb47b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)OCC(CC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/85781,PubChem,CCCCC(CC)COC(=O)OCC(CC)CCCC,Train,1,2702,training
-"AU_HCIS:
-3-Buten-2-one, 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-
-
-US_HSDB:
-beta-Ionone",,14901-07-6,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5910
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8269",,,"AU_HCIS, US_HSDB",2,CC1=C(C(CCC1)(C)C)/C=C/C(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/638014,PubChem,CC(=O)/C=C/C1=C(C)CCCC1(C)C,Train,1,2702,training
-"EU_REACH:
-2-propylheptyl acrylate",,149021-58-9,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5532/7/4/2/?documentUUID=2abc8d05-dbd4-4dd3-b602-a3dfcfa91f9b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCC(CCC)COC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/23500968,PubChem,C=CC(=O)OCC(CCC)CCCCC,Train,1,2702,training
-"EU_CLP:
-disul (ISO); 2-(2,4-dichlorophenoxy)ethyl hydrogensulphate; 2,4-DES",,149-26-8,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC(=C(C=C1Cl)Cl)OCCOS(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/8701,PubChem,O=S(=O)(O)OCCOc1ccc(Cl)cc1Cl,Test,1,2702,training
-"EU_REACH:
-trimethoxymethane
-
-JP_CHRIP:
-Methyl orthoformate","JP_CHRIP:
-Methane, trimethoxy-",149-73-5,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14129/7/4/2/?documentUUID=532e8b32-f4c6-4afe-98b9-4174b82b785d
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0133e.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-The substance was classified as ""Not classified"" based on the documented case of ""not irritating"" (IUCLID (2000)) resulted from the rabbit test (OECD TG404, GLP-compliant) in which the score of both erythema and edema was 0.",Provided,"EU_REACH, JP_CHRIP",2,COC(OC)OC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J8.664I,J-GLOBAL,COC(OC)OC,Train,1,2702,training
-"NZ_CCID:
-Dichloromethylphenylsilane",,149-74-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FB803C7D-6313-4D30-8B48-78C1425CC6BF,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C[Si](C1=CC=CC=C1)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/9006,PubChem,C[Si](Cl)(Cl)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-Gallic acid","NZ_CCID:
-3,4,5-Trihydroxybenzoic acid, Benzoic acid, 3,4,5-trihydroxy-",149-91-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8452DAF0-3185-459E-A932-FB1A309650C1,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 38 Irritating to skin. [http://physchem.ox.ac.uk/MSDS/TR/3,4,5-trihydroxybenzoic_acid.html]
-Eye Irritation
-R-PHRASE: R 36 Irritating to eyes. [http://physchem.ox.ac.uk/MSDS/TR/3,4,5-trihydroxybenzoic_acid.html]",,NZ_CCID,1,C1=C(C=C(C(=C1O)O)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/370,PubChem,O=C(O)c1cc(O)c(O)c(O)c1,Train,1,2702,training
-"NZ_CCID:
-Diphenylphosphinic chloride",,1499-21-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1E404F52-F9D0-4766-A81A-9E7642B6AC09,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)P(=O)(C2=CC=CC=C2)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/73910,PubChem,O=P(Cl)(c1ccccc1)c1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-(2E)-2-[2-[(2,5-dimethylphenoxy)methyl]phenyl]-2-methoxyimino-N-methylacetamide (synonym: dimoxystrobin)",,149961-52-4,NC,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-mhlw-0004.html,"JP_CHRIP:
-【分類根拠】
-（１）より、区分に該当しない。
-
-【根拠データ】
-（１）ウサギ（n = 6）を用いた皮膚刺激性試験（OECD TG 404、GLP、半閉塞、4時間適用、9日観察）において、みられた影響は8日以内に回復した（紅斑・痂皮スコア：0/0/0/0.7/1/2、浮腫スコア：0/0/0/0/0/0）との報告がある（ECHA RAC Opinion (2020)、CLH Report (2019)、EFSA (2005)）。",Provided,JP_CHRIP,1,CNC(=O)/C(=N/OC)/c1ccccc1COc1cc(C)ccc1C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.077.232J,J-GLOBAL,CNC(=O)/C(=N/OC)c1ccccc1COc1cc(C)ccc1C,Train,1,2702,training
-"EU_REACH:
-13-DOCOSENAMIDE, N-[3-(DIMETHYLAMINO)PROPYL]-, (13Z)-",,149968-48-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12095/7/4/2/?documentUUID=5ed07350-0026-46f1-818e-50b4f2c93d24,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCC/C=C\CCCCCCCCCCCC(=O)NCCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/87989022,PubChem,CCCCCCCC/C=C\CCCCCCCCCCCC(=O)NCCCN(C)C,Test,1,2702,training
-"EU_REACH:
-4-amino-3,6-dichloropyridine-2-carboxylic acid",,150114-71-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16971/7/4/2/?documentUUID=f7c869cd-5b79-4f6c-b0d4-7f0b49760b7a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(C(=C(N=C1Cl)C(=O)O)Cl)N,https://pubchem.ncbi.nlm.nih.gov/compound/213012,PubChem,Nc1cc(Cl)nc(C(=O)O)c1Cl,Train,1,2702,training
-"NZ_CCID:
-4-Aminobenzoic acid","NZ_CCID:
-p-Aminobenzoic acid",150-13-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6B5664C2-583A-471F-8B20-A809B42B1F5D,"NZ_CCID:
-Skin Irritation
-REMARK: Classification based on company data.
-Eye Irritation
-REMARK: Classification based on company data.",,NZ_CCID,1,C1=CC(=CC=C1C(=O)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/978,PubChem,Nc1ccc(C(=O)O)cc1,Train,1,2702,training
-"NZ_CCID:
-3-Methoxyphenol",,150-19-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8A3A197C-E41F-4DFE-B84A-E2E3B80CBE20,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,COC1=CC=CC(=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/9007,PubChem,COc1cccc(O)c1,Train,1,2702,training
-"EU_REACH:
-1,4-dimethoxybenzene",,150-78-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2003/7/4/2/?documentUUID=501a3e97-e8ba-46c7-810c-f3a08864747d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC=C(C=C1)OC,https://pubchem.ncbi.nlm.nih.gov/compound/9016,PubChem,COc1ccc(OC)cc1,Train,1,2702,training
-"EU_CLP:
-(4aS-cis-)-6-benzyl-octahydropyrrolo[3.4-b]pyridine",,151213-39-7,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1C[C@H]2CN(C[C@H]2NC1)CC3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/10198297,PubChem,c1ccc(CN2C[C@@H]3CCCN[C@@H]3C2)cc1,Test,1,2702,training
-"EU_CLP:
-E-ethyl-4-oxo-4-phenylcrotonate",,15121-89-8,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCOC(=O)/C=C/C(=O)C1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/5369605,PubChem,CCOC(=O)/C=C/C(=O)c1ccccc1,Test,1,2702,training
-"NZ_CCID:
-2,6-Difluoropyridine",,1513-65-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FA675B53-0048-4446-A0A5-ED1017377BA9,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=NC(=C1)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/73934,PubChem,Fc1cccc(F)n1,Train,1,2702,training
-"AU_HCIS:
-ethyleneimine
-
-JP_CHRIP:
-Ethyleneimine; Aziridine (with stabilizer)","AU_HCIS:
-Aziridine
-
-JP_CHRIP:
-Azacyclopropane
-Dihydro-1H-azirine
-Ethyleneimine",151-56-4,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1998
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2083e.html","JP_CHRIP:
-[Rationale for the Classification]
-It was classified in Category 1 from (1) - (4).
-
-[Evidence Data]
-(1) This substance was corrosive, and contact with the skin caused erythema, skin burns, and blisters, and entry in the eye caused erythema, pain, and severe burns (Environmental Risk Assessment for Chemical Substances vol. 12 (Ministry of the Environment, 2014)).
-(2) In a test with rabbits, this substance caused necrosis of the skin within 1.5 hours after application and corrosion of the cornea in the eye (AICIS (formerly, NICNAS) IMAP (2014), REACH registration dossier (Access on August 2020)).
-(3) Skin disorder, disorder of the anterior part of the eye, disorder of the respiratory tract/lung, or disorder of the kidney caused by this substance was designated as occupational diseases listed in Appended Table 1-2 of the Ordinance for Enforcement of the Labor Standards Act (notification No. 33 (1996)).
-(4) This substance was strongly irritative and corrosive to the skin and mucosa (GESTIS (Access on May 2020), HSDB (Access on May 2020)).
-
-[Reference Data, etc.]
-(5) It was classified in Skin Corr. 1B (H314) in EU-CLP classification (EU CLP classification (Access on August 2020)).",,"AU_HCIS, JP_CHRIP",2,C1CN1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.966A,J-GLOBAL,C1CN1,Train,1,2702,training
-"NZ_CCID:
-1-Acetoxy-1,3-butadiene (mixture of cis and trans isomers)","NZ_CCID:
-1-acetoxy-1,3-butadiene",1515-76-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FAA0C4D8-2F42-48F5-8AE0-F3966D730D33,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(=O)O/C=C/C=C,https://pubchem.ncbi.nlm.nih.gov/compound/5363433,PubChem,C=C/C=C/OC(C)=O,Train,1,2702,training
-"EU_CLP:
-morpholine-4-carbonyl chloride",,15159-40-7,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1COCCN1C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/84810,PubChem,O=C(Cl)N1CCOCC1,Test,1,2702,training
-"NZ_CCID:
-1,1,1,5,5,5-Hexafluoroacetylacetone","NZ_CCID:
-1,1,1,5,5,5-hexafluoro-2,4-pentanedione",1522-22-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3EC4E2FD-DD90-41BE-95CE-D75AFAD0B729,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(C(=O)C(F)(F)F)C(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/73706,PubChem,O=C(CC(=O)C(F)(F)F)C(F)(F)F,Train,1,2702,training
-"EU_REACH:
-(3E,7E)-cyclododeca-3,7-dien-1-one; (4E,8Z)-cyclododeca-4,8-dien-1-one; (4Z,8E)-cyclododeca-4,8-dien-1-one",,15229-79-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20023/7/4/2/?documentUUID=4df1eab4-d575-4af1-b696-7480cc46d40e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC=CCCC=CCCC(=O)C1,https://pubchem.ncbi.nlm.nih.gov/compound/601176,PubChem,O=C1CCC=CCCC=CCCC1,Train,1,2702,training
-"JP_CHRIP:
-3-[(2-Chloro-1,3-thiazol-5-yl)methyl]-5-methyl-N-nitro-1,3,5-oxadiazinan-4-imine; Thiamethoxam",,153719-23-4,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0026e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified as ""Not classified"" from (1).
-
-[Evidence Data]
-(1) It is reported that in a skin irritation test with rabbits (n = 6) (OECD TG 404, GLP, 4-hour application, 72-hour observation), no skin reactions were seen in any animal (erythema/eschar score: 0/0/0/0/0/0, edema score: 0/0/0/0/0/0) (EU CLH report (2018), RAC Opinion (2019), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), JMPR (2010), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2018)).",Provided,JP_CHRIP,1,CN1COCN(Cc2cnc(Cl)s2)C1=N[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.067.655J,J-GLOBAL,CN1COCN(Cc2cnc(Cl)s2)C1=N[N+](=O)[O-],Train,1,2702,training
-"NZ_CCID:
-Pivalic anhydride",,1538-75-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BC8CED4D-99B1-4757-9D22-A2F58663652A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(C)(C)C(=O)OC(=O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/15234,PubChem,CC(C)(C)C(=O)OC(=O)C(C)(C)C,Train,1,2702,training
-"KR_NCIS:
-4,4'-Methylenebis[N-(1-methylpropyl)cyclohexanamine]","KR_NCIS:
-Cyclohexanamine, 4,4'-methylenebis[N-(1-methylpropyl)-; N,N'-Di-sec-butyl-4,4'-methylenebis(cyclohexylamine)",154279-60-4,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCC(C)NC1CCC(CC1)CC2CCC(CC2)NC(C)CC,https://pubchem.ncbi.nlm.nih.gov/compound/21885336,PubChem,CCC(C)NC1CCC(CC2CCC(NC(C)CC)CC2)CC1,Train,1,2702,training
-"EU_REACH:
-methyl 2-(4-bromophenyl)-2-methylpropanoate",,154825-97-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17257/7/4/2/?documentUUID=c6648981-16fc-4278-9771-2ad5e9b18bc3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C1=CC=C(C=C1)Br)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/3651431,PubChem,COC(=O)C(C)(C)c1ccc(Br)cc1,Test,1,2702,training
-"EU_REACH:
-(1r,1'r,4r,4'r)-4-ethenyl-4'-(4-methylphenyl)-1,1'-bi(cyclohexane)",,155041-85-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30138/7/4/2/?documentUUID=d45d3bd3-5011-42ca-883b-2f1941c4311c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)C2CCC(CC2)C3CCC(CC3)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/20580010,PubChem,C=CC1CCC(C2CCC(c3ccc(C)cc3)CC2)CC1,Train,1,2702,training
-"EU_REACH:
-2,2-difluoroethyl acetate",,1550-44-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33878/7/4/2/?documentUUID=bb3e61ae-a311-455b-8d91-060e5b10c2aa,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)OCC(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/137074,PubChem,CC(=O)OCC(F)F,Train,1,2702,training
-"EU_REACH:
-1-{5-[(3-chloro-2-fluorophenyl)methyl]-2,4-dimethoxyphenyl}ethan-1-one",,1551444-36-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18432/7/4/2/?documentUUID=9ba1a29e-18c3-4cd9-a28a-354d3ac2ae48,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C1=C(C=C(C(=C1)CC2=C(C(=CC=C2)Cl)F)OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/59551825,PubChem,COc1cc(OC)c(C(C)=O)cc1Cc1cccc(Cl)c1F,Train,1,2702,training
-"EU_REACH:
-2-[(2-hydroxyethyl)(octyl)amino]ethan-1-ol",,15520-05-5,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18314/7/4/2/?documentUUID=9cb243b3-ec77-4480-97aa-d32002abc7f4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCN(CCO)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/84963,PubChem,CCCCCCCCN(CCO)CCO,Train,1,2702,training
-"EU_REACH:
-2-(2H-1,2,3-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-(2,2,4,6,6-pentamethyl-3,5-dioxa-2,4,6-trisilaheptan-4-yl)propyl]phenol",,155633-54-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17628/7/4/2/?documentUUID=ad5a5a2b-88d4-4c69-a876-e30be14c6182,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C(=C1)N2N=C3C=CC=CC3=N2)O)CC(C)C[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/9848888,PubChem,Cc1cc(CC(C)C[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C)c(O)c(-n2nc3ccccc3n2)c1,Train,1,2702,training
-"KR_NCIS:
-Tris(trimethylsilyl)phosphine",,15573-38-3,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C[Si](C)(C)P([Si](C)(C)C)[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/272683,PubChem,C[Si](C)(C)P([Si](C)(C)C)[Si](C)(C)C,Train,1,2702,training
-"EU_REACH:
-2(3H)-Benzofuranone, 5,7-bis(1,1-dimethylethyl)-3-(4-hydroxy-3,5-",,155810-87-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20257/7/4/2/?documentUUID=5728f3de-40b3-4af5-b55c-d799ff7fbf8f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=CC(=C1O)C)C2C3=C(C(=CC(=C3)C(C)(C)C)C(C)(C)C)OC2=O,https://pubchem.ncbi.nlm.nih.gov/compound/11100649,PubChem,Cc1cc(C2C(=O)Oc3c2cc(C(C)(C)C)cc3C(C)(C)C)cc(C)c1O,Train,1,2702,training
-"KR_NCIS:
-Dichloro(chloromethyl)methylsilane",,1558-33-4,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C[Si](CCl)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/73788,PubChem,C[Si](Cl)(Cl)CCl,Train,1,2702,training
-"EU_REACH:
-(4E,9E)-7-ethenyl-2,4,10,12-tetramethyl-7-{[(E)-(4-methylpentan-2-ylidene)amino]oxy}-6,8-dioxa-5,9-diaza-7-silatrideca-4,9-diene; (4Z,9E)-7-ethenyl-2,4,10,12-tetramethyl-7-{[(E)-(4-methylpentan-2-ylidene)amino]oxy}-6,8-dioxa-5,9-diaza-7-silatrideca-4,9-diene; (4Z,9Z)-7-ethenyl-2,4,10,12-tetramethyl-7-{[(E)-(4-methylpentan-2-ylidene)amino]oxy}-6,8-dioxa-5,9-diaza-7-silatrideca-4,9-diene; (4Z,9Z)-7-ethenyl-2,4,10,12-tetramethyl-7-{[(Z)-(4-methylpentan-2-ylidene)amino]oxy}-6,8-dioxa-5,9-diaza-7-silatrideca-4,9-diene",,156145-64-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16578/7/4/2/?documentUUID=29de4d5f-3585-4aa3-89e0-44decacc3e32,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C/C(=N/O[Si](O/N=C(/CC(C)C)\C)(O/N=C(/CC(C)C)\C)C=C)/C)C,https://pubchem.ncbi.nlm.nih.gov/compound/15219159,PubChem,C=C[Si](O/N=C(\C)CC(C)C)(O/N=C(\C)CC(C)C)O/N=C(\C)CC(C)C,Test,1,2702,training
-"EU_CLP:
-2-ethyl-2-[[(1-oxoallyl)oxy] methyl]-1,3-propanediyl diacrylate; 2,2-bis(acryloyloxymethyl)butyl acrylate; trimethylolpropane triacrylate",,15625-89-5,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCC(COC(=O)C=C)(COC(=O)C=C)COC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/27423,PubChem,C=CC(=O)OCC(CC)(COC(=O)C=C)COC(=O)C=C,Test,1,2702,training
-"EU_REACH:
-2-[({[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}carbonyl)oxy]ethan-1-ol",,156324-78-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23541/7/4/2/?documentUUID=66308ee3-ac34-4b1c-a22d-fb6e7a9c96b2,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H]1CC[C@H]([C@@H](C1)OC(=O)OCCO)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/189860,PubChem,CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)OCCO,Train,1,2702,training
-"NZ_CCID:
-(4-Hydroxyphenyl)-acetic acid","NZ_CCID:
-4-hydroxyphenylacetic acid",156-38-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F2541CAE-4059-4ABB-9CAE-C2F2ED55BF55,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1CC(=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/127,PubChem,O=C(O)Cc1ccc(O)cc1,Train,1,2702,training
-"NZ_CCID:
-Phosphorous acid, 2-ethylhexyl diphenyl ester",,15647-08-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/17B61F18-7807-4C94-A348-05E3F645B7E4,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,CCCCC(CC)COP(OC1=CC=CC=C1)OC2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/85888,PubChem,CCCCC(CC)COP(Oc1ccccc1)Oc1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-trans-1,2-Dichloroethylene
-
-NZ_CCID:
-Ethene, 1,2-dichloro-, (1E)-","JP_CHRIP:
-Acetylene dichloride, trans-
-Dichloroetylene, trans
-Ethene, 1,2-dichloro-, (E)-
-RCRA waste number U079
-trans-1,2-Dichloroethylene
-
-NZ_CCID:
-trans-1,2-Dichloroethylene",156-60-5,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2046e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BAB82E64-0745-4347-BF90-DD46B46F9007","JP_CHRIP:
-There are reports that mild to moderate erythema was observed in a skin irritation test by 24-hour occlusive application of a 0.5 mL of undiluted liquid of this substance to rabbits (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (1996), IRIS TR (2010)). In addition, there is a report that, after application of 5,000 mg/kg of this substance to the skin of rabbits, although severe skin irritation was observed, recovery was unknown (ATSDR (1996)). Moreover, in humans, there is a description that it was irritating to the skin (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)). From the above result, it was classified in Category 2.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Moderate
-REFERENCE SOURCE: [Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- (1,11,1990)] [RTECS]
-Eye Irritation
-EYE - STANDARD DRAIZE TEST
-Rabbit
-ROUTE: Eyes; DOSE: 10 mg; REACTION: Moderate
-[Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- (1,11,1990)]
-[RTECS]",,"JP_CHRIP, NZ_CCID",2,Cl/C=C/Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.559C,J-GLOBAL,Cl/C=C/Cl,Train,1,2702,training
-"NZ_CCID:
-2,4-Diamino-6-chloropyrimidine","NZ_CCID:
-4-chloro-2,6-diaminopyrimidine",156-83-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/189530C5-D7BE-452B-AF8E-A02B61E1687F,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=C(N=C(N=C1Cl)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/67432,PubChem,Nc1cc(Cl)nc(N)n1,Train,1,2702,training
-"JP_CHRIP:
-3-Amino-1-propanol
-
-NZ_CCID:
-3-Amino-1-propanol","JP_CHRIP:
-3-amino-1-propanol",156-87-6,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0090e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8536FE88-C7C1-406F-A661-FD36BC5689B4","JP_CHRIP:
-It was classified in Category 1 because it was rated as 5 (corresponding to severe erythema and edema or slight necrosis) on a scale from 1 to 10 (10 being the most severe) in a test by a 24-hour open application of 0.01 mL of the undiluted substance to the rabbit skin (PATTY (5th, 2001)), and the pH of the substance was 11.6 (20 deg C, 10 g/L).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,NCCCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.560G,J-GLOBAL,NCCCO,Train,1,2702,training
-"JP_CHRIP:
-1-Propoxy-2-propanol
-
-US_HSDB:
-1-PROPOXY-2-PROPANOL",,1569-01-3,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0039e.html
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/6482","JP_CHRIP:
-On the basis that occlusive applications of 0.5 mL for 4 hours to rabbit skins produced mild to moderate erythema and edema in 4 out of 6 animals, but no necrosis or ulceration (PATTY (5th, 2001)), it was classified in Category 2.
-Besides, another test of an occlusive application to rabbits for 24 hours reports slightly irritant (ECETOC TR 95 (2005)), and another reports that severe irritation with persistent fissuring, desquamation, ulceration, and necrosis appeared under more rigorous conditions (PATTY (5th, 2001)).",,"JP_CHRIP, US_HSDB",2,CCCOCC(C)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J13.129F,J-GLOBAL,CCCOCC(C)O,Train,1,2702,training
-"JP_CHRIP:
-Propylene glycol monoethyl ether; 1-Ethoxy-2-propanol","JP_CHRIP:
-2-Propanol, 1-ethoxy-
-1-Ethoxy-2-propanol
-2-Propanol-1-ethoxy
-2PG1EE",1569-02-4,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2031e.html,"JP_CHRIP:
-[Rationale for the Classification]
-Based on (1), it was classified as ""Not classified.""
-
-[Evidence Data]
-(1) In a skin irritation test with rabbits equivalent or similar to OECD TG 404, slight erythema was observed at 1 and 24 hours after exposure and disappeared after 48 hours. Flaking was also noted, but it disappeared within 7 days. The mean scores for erythema and edema at 24/48/72 hours were 0-1.33 and 0, respectively (REACH registration dossier (Access on August, 2019)).
-
-[Reference Data, etc.]
-(2) This substance was slightly irritating to the skin of rabbits, producing minimal transient reddening and edema with slight flaking of the skin after 72 hours (ACGIH (7th, 2019)).
-(3) Moderate irritation was observed in skin irritation tests by 24-hour occlusive or 4-hour semi-occlusive application to rabbits (ECETOC TR64 (1995)).
-(4) This substance is slightly irritating to the skin (PATTY (6th, 2012)).",Provided,JP_CHRIP,1,CCOCC(C)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J13.130J,J-GLOBAL,CCOCC(C)O,Train,1,2702,training
-"NZ_CCID:
-Cyclohexanethiol","NZ_CCID:
-Cyclohexyl thiol, Cyclohexylthiol",1569-69-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/162CF71B-F53C-49DC-8535-648ECA3AD4A4,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1CCC(CC1)S,https://pubchem.ncbi.nlm.nih.gov/compound/15290,PubChem,SC1CCCCC1,Train,1,2702,training
-"JP_CHRIP:
-4-chloro-o-cresol; 4-chloro-2-methyl phenol
-
-NZ_CCID:
-4-Chloro-2-cresol","JP_CHRIP:
-para-Chloro-ortho-cresol
-Phenol, 4-chloro-2-methyl
-Phenol, 4-chloro-2-methyl-
-
-NZ_CCID:
-Phenol, 4-chloro-2-methyl-",1570-64-5,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0217e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/679E8707-E8D9-4012-86E4-8DC6068F8980","JP_CHRIP:
-In the rabbit tests (OECD TG404, GLP-compliant), the substance was evaluated to be highly irritating and its Primary Dermal Irritation Index value was 8 (which is the maximum score) (SIDS (accessed in December 2008)). In other two tests using rabbits, the substance was concluded to be corrosive (IUCLID (2000)). Based on these results, the substance was classified into Category 1. In other tests using unknown animal species, necrosis was detected 1 minute after the exposure (SIDS (accessed in December 2008), BUA (Report 134, 1993)). Although these results indicate a more refined classification of the substance into Category 1A, further classification was not considered due to lack of information on the species and quantity of animals tested.
-
-NZ_CCID:
-Skin Irritation
-R-PHRASE: R 35 Causes severe burns. [NCLASS]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Irritating
-REFERENCE SOURCE: BASF AG Ludwigshafen BASF AG, Abteilung Toxikologie; unveroeffentlichte Untersuchung (XXVI/647), 27.02.78
-[IUCLID 2000]
-REMARK: EC classification: Risk of serious damage to eyes.",Provided,"JP_CHRIP, NZ_CCID",2,Cc1cc(Cl)ccc1O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J33.994F,J-GLOBAL,Cc1cc(Cl)ccc1O,Train,1,2702,training
-"EU_REACH:
-4'-ethyl-2,3-difluoro-4-(4-propylphenyl)-1,1'-biphenyl",,157248-25-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21094/7/4/2/?documentUUID=26f0d263-0620-4a22-94cd-8d378aa360e1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1=CC=C(C=C1)C2=C(C(=C(C=C2)C3=CC=C(C=C3)CC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/53649556,PubChem,CCCc1ccc(-c2ccc(-c3ccc(CC)cc3)c(F)c2F)cc1,Train,1,2702,training
-"KR_NCIS:
-4-(Aminomethyl)-1,8-octanediamine",,1572-55-0,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C(CCN)CC(CCCN)CN,https://pubchem.ncbi.nlm.nih.gov/compound/94211,PubChem,NCCCCC(CN)CCCN,Train,1,2702,training
-"EU_CLP:
-2-methyl-4-(1,1-dimethylethyl)-6-(1-methyl-pentadecyl)-phenol",,157661-93-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCCCCCCCCCCCCCC(C)C1=C(C(=CC(=C1)C(C)(C)C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/18961322,PubChem,CCCCCCCCCCCCCCC(C)c1cc(C(C)(C)C)cc(C)c1O,Test,1,2702,training
-"EU_CLP:
-methyl 2-benzylidene-3-oxobutyrate",,15768-07-7,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(=O)/C(=C\C1=CC=CC=C1)/C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/641409,PubChem,COC(=O)/C(=C/c1ccccc1)C(C)=O,Test,1,2702,training
-"EU_REACH:
-4,4'-[(3,3'-dichlorobiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis[5-methyl-2-(4-methylphenyl)-2,4-dihydro-3H-pyrazol-3-one]",,15793-73-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14131/7/4/2/?documentUUID=7653d6b2-45ae-4eab-b13e-35c2aa81a938,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)N2C(=O)C(C(=N2)C)N=NC3=C(C=C(C=C3)C4=CC(=C(C=C4)N=NC5C(=NN(C5=O)C6=CC=C(C=C6)C)C)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/85908,PubChem,CC1=NN(c2ccc(C)cc2)C(=O)C1N=Nc1ccc(-c2ccc(N=NC3C(=O)N(c4ccc(C)cc4)N=C3C)c(Cl)c2)cc1Cl,Train,1,2702,training
-"EU_REACH:
-(2S)-1-isopropoxy-1-oxopropan-2-yl pivalate",,1584709-99-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21514/7/4/2/?documentUUID=d0cdecf9-d474-4b4e-aad8-951acd97d231,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H](C(=O)OC(C)C)OC(=O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/121317744,PubChem,CC(C)OC(=O)[C@H](C)OC(=O)C(C)(C)C,Train,1,2702,training
-"AU_HCIS:
-Phenol, 4-nonyl-2,6-bis(1-phenylethyl)-",,15860-96-5,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6709,,,AU_HCIS,1,CCCCCCCCCC1=CC(=C(C(=C1)C(C)C2=CC=CC=C2)O)C(C)C3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/85922,PubChem,CCCCCCCCCc1cc(C(C)c2ccccc2)c(O)c(C(C)c2ccccc2)c1,Train,1,2702,training
-"EU_CLP:
-1-bromo-2-methylpropyl propionate",,158894-67-8,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCC(=O)OC(C(C)C)Br,https://pubchem.ncbi.nlm.nih.gov/compound/19094335,PubChem,CCC(=O)OC(Br)C(C)C,Test,1,2702,training
-"EU_CLP:
-2-methoxypropanol",,1589-47-5,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(CO)OC,https://pubchem.ncbi.nlm.nih.gov/compound/14846,PubChem,COC(C)CO,Test,1,2702,training
-"EU_REACH:
-N,N',N''-tricyclohexyl-1-methylsilanetriamine",,15901-40-3,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23897/7/4/2/?documentUUID=3d597a10-33d3-40b4-bd12-48e457a6d04e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](NC1CCCCC1)(NC2CCCCC2)NC3CCCCC3,https://pubchem.ncbi.nlm.nih.gov/compound/85178,PubChem,C[Si](NC1CCCCC1)(NC1CCCCC1)NC1CCCCC1,Train,1,2702,training
-"EU_REACH:
-N-(5-chloro-2-methoxyphenyl) -2-[(2-methoxy-4-nitrophenyl) diazenyl]-3-oxobutanamide",,15993-42-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10410/7/4/2/?documentUUID=9982e4c8-d371-4ec9-8a46-071f80c35bdf,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=C(C=CC(=C1)Cl)OC)N=NC2=C(C=C(C=C2)[N+](=O)[O-])OC,https://pubchem.ncbi.nlm.nih.gov/compound/85940,PubChem,COc1cc([N+](=O)[O-])ccc1N=NC(C(C)=O)C(=O)Nc1cc(Cl)ccc1OC,Train,1,2702,training
-"EU_REACH:
-2-[2-(2-methoxyethoxy)ethoxy]acetic acid",,16024-58-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25107/7/4/2/?documentUUID=7915d090-f6b8-493c-a945-890267af5d4d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COCCOCCOCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/85241,PubChem,COCCOCCOCC(=O)O,Train,1,2702,training
-"NZ_CCID:
-Iodotrimethylsilane","NZ_CCID:
-trimethylsilyl iodide",16029-98-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D9BDB066-A838-4418-BBF8-C969AE8216B8,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C[Si](C)(C)I,https://pubchem.ncbi.nlm.nih.gov/compound/85247,PubChem,C[Si](C)(C)I,Train,1,2702,training
-"NZ_CCID:
-2-Amino-3-methylpyridine",,1603-40-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0A07DCCF-993C-46AB-9054-9332D68ACD95,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=C(N=CC=C1)N,https://pubchem.ncbi.nlm.nih.gov/compound/15347,PubChem,Cc1cccnc1N,Train,1,2702,training
-"NZ_CCID:
-2-Amino-5-methylpyridine",,1603-41-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E1D7C838-6ECC-4241-8C93-5AEC60FD20CE,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=CN=C(C=C1)N,https://pubchem.ncbi.nlm.nih.gov/compound/15348,PubChem,Cc1ccc(N)nc1,Train,1,2702,training
-"EU_REACH:
-3-[4-(2-hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid",,16052-06-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32799/7/4/2/?documentUUID=c4e99cf8-df99-4a77-adcb-9e590c1506d0,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CN(CCN1CCCS(=O)(=O)O)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/85255,PubChem,O=S(=O)(O)CCCN1CCN(CCO)CC1,Train,1,2702,training
-"EU_REACH:
-4,4,7,7-tetraethoxy-3,8-dioxa-4,7-disiladecane",,16068-37-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23679/7/4/2/?documentUUID=54b63d5d-853b-48f8-8a5b-66ab86d5b0c5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](CC[Si](OCC)(OCC)OCC)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/85266,PubChem,CCO[Si](CC[Si](OCC)(OCC)OCC)(OCC)OCC,Train,1,2702,training
-"NZ_CCID:
-Diethyl dicarbonate","NZ_CCID:
-diethyl pyrocarbonate",1609-47-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C3EE8035-EE77-4D6E-BA75-1B48BB88D654,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCOC(=O)OC(=O)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/3051,PubChem,CCOC(=O)OC(=O)OCC,Train,1,2702,training
-"EU_REACH:
-N-phenyl-N-piperidin-4-ylpropionamide",,1609-66-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20255/7/4/2/?documentUUID=214b9c45-1f8f-4bfd-9c17-f3f5d60f4e61,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(=O)N(C1CCNCC1)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/259381,PubChem,CCC(=O)N(c1ccccc1)C1CCNCC1,Train,1,2702,training
-"KR_NCIS:
-tert-Butyl isocyanate",,1609-86-5,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CC(C)(C)N=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/62412,PubChem,CC(C)(C)N=C=O,Train,1,2702,training
-"KR_NCIS:
-2-Propyn-1-ol, 1-methanesulfonate",,16156-58-4,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CS(=O)(=O)OCC#C,https://pubchem.ncbi.nlm.nih.gov/compound/305925,PubChem,C#CCOS(C)(=O)=O,Train,1,2702,training
-"EU_REACH:
-ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate",,161797-99-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18541/7/4/2/?documentUUID=467abe53-de99-4235-8031-0a59623d036f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1=C(N=C(S1)C2=CC=C(C=C2)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/135509402,PubChem,CCOC(=O)c1sc(-c2ccc(O)cc2)nc1C,Train,1,2702,training
-"EU_REACH:
-1,1,1,2,2,3,3-heptafluoro-3-[(1,2,2-trifluoroethenyl)oxy]propane",,1623-05-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23696/7/4/2/?documentUUID=d1525b16-81a4-45fa-ab8d-58c0127cb8a6,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(=C(F)F)(OC(C(C(F)(F)F)(F)F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/15388,PubChem,FC(F)=C(F)OC(F)(F)C(F)(F)C(F)(F)F,Train,1,2702,training
-"AU_HCIS:
-Phosphoric acid, monobutyl ester",,1623-15-0,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6801,,,AU_HCIS,1,CCCCOP(=O)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/15389,PubChem,CCCCOP(=O)(O)O,Train,1,2702,training
-"EU_CLP:
-1-(mercaptomethyl)cyclopropylacetic acid",,162515-68-6,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1CC1(CC(=O)O)CS,https://pubchem.ncbi.nlm.nih.gov/compound/9793825,PubChem,O=C(O)CC1(CS)CC1,Test,1,2702,training
-"JP_CHRIP:
-Methyl tert-butyl ether [MTBE]
-
-US_HSDB:
-Methyl t-butyl ether","JP_CHRIP:
-1-methoxy-1,1-dimethylethane
-2-Methoxy-2-methyl propane
-Methyl tert-butyl ether
-Methyl tertiary-butyl ether
-Methyl-1,1-dimethylethyl ether
-MTBE
-Propane, 2-methoxy-2-methyl-
-tert-butyl methyl ether
-tert-Butyl methyl ether; tert-Butyl methyl ether; Methyl tert-butyl ether",1634-04-4,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2045e.html
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/5847","JP_CHRIP:
-Based on a report that in a skin irritation test (OECD TG 404 compliant) with rabbits, moderate to severe edema and moderate erythema were observed by an application of this substance for 4 hours (EU-RAR (2002)), it was classified in Category 2. Besides, this substance is classified as ""Skin Irrit. 2"" in the EU CLP classification (ECHA CL Inventory (Access on June 2017)).",Provided,"JP_CHRIP, US_HSDB",2,COC(C)(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J27.142J,J-GLOBAL,COC(C)(C)C,Train,1,2702,training
-"EU_REACH:
-3-(trimethoxysilyl)propyl (2E,4E)-hexa-2,4-dienoate",,163802-53-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10924/7/4/2/?documentUUID=c9dbab23-fa0f-483e-975c-6e96040e747b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C/C=C/C=C/C(=O)OCCC[Si](OC)(OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/58361202,PubChem,C/C=C/C=C/C(=O)OCCC[Si](OC)(OC)OC,Train,1,2702,training
-"EU_REACH:
-diethyl phenylphosphonite",,1638-86-4,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12512/7/4/2/?documentUUID=09cb9384-150d-4ed0-92e9-a3443d0db3ab,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOP(C1=CC=CC=C1)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/74225,PubChem,CCOP(OCC)c1ccccc1,Test,1,2702,training
-"EU_REACH:
-p-Nitrobenzoic acid-2-ethylhexylester",,16397-70-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7389/7/4/2/?documentUUID=e1fd1080-6a50-4ab9-8c20-84e20962c1b5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)C1=CC=C(C=C1)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/591313,PubChem,CCCCC(CC)COC(=O)c1ccc([N+](=O)[O-])cc1,Train,1,2702,training
-"EU_REACH:
-N,N',N''-tributyl-1-methylsilanetriamine",,16411-33-9,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23686/7/4/2/?documentUUID=583023cc-f067-475d-95dc-be3ca2cd1d81,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCN[Si](C)(NCCCC)NCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/85403,PubChem,CCCCN[Si](C)(NCCCC)NCCCC,Train,1,2702,training
-"EU_REACH:
-1,1,1,2,2,3,3-heptafluoro-3-({1,1,1,2,3,3-hexafluoro-3-[(1,2,2-trifluoroethenyl)oxy]propan-2-yl}oxy)propane",,1644-11-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24699/7/4/2/?documentUUID=e315d2e3-5c18-412c-a432-fccd6c44b36c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(=C(F)F)(OC(C(C(F)(F)F)(OC(C(C(F)(F)F)(F)F)(F)F)F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/102662,PubChem,FC(F)=C(F)OC(F)(F)C(F)(OC(F)(F)C(F)(F)C(F)(F)F)C(F)(F)F,Train,1,2702,training
-"EU_REACH:
-N-[3-(diethylamino)propyl]-4-[(1E)-2-{2-oxo-1-[(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl)carbamoyl]propyl}diazen-1-yl]benzamide",,164578-14-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31229/7/4/2/?documentUUID=7033ee1c-16aa-42e8-88b8-6ab9166e6c35,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(CC)CCCNC(=O)C1=CC=C(C=C1)N=NC(C(=O)C)C(=O)NC2=CC3=C(C=C2)NC(=O)N3,https://pubchem.ncbi.nlm.nih.gov/compound/57490352,PubChem,CCN(CC)CCCNC(=O)c1ccc(N=NC(C(C)=O)C(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)cc1,Train,1,2702,training
-"EU_REACH:
-3-butoxypropylamine
-
-KR_NCIS:
-3-Butoxypropylamine",,16499-88-0,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26854/7/4/2/?documentUUID=b2bb62df-5dda-44e6-a4bf-c1b79e65f760
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,"EU_REACH, KR_NCIS",2,CCCCOCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/85461,PubChem,CCCCOCCCN,Train,1,2702,training
-"AU_HCIS:
-1,6-1Octadien-3-ol, 3,7-dimethyl-, acetate, (R)-",,16509-46-9,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6452,,,AU_HCIS,1,CC(=CCC[C@](C)(C=C)OC(=O)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/442474,PubChem,C=C[C@@](C)(CCC=C(C)C)OC(C)=O,Train,1,2702,training
-"EU_REACH:
-1-(cyclopropylmethyl)-4-methoxybenzene",,16510-27-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/9760/7/4/2/?documentUUID=4630094e-73e7-4c87-8220-1f67e6c4459c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC=C(C=C1)CC2CC2,https://pubchem.ncbi.nlm.nih.gov/compound/6422476,PubChem,COc1ccc(CC2CC2)cc1,Train,1,2702,training
-"JP_CHRIP:
-1-Methyl-2-nitro-3-[(3-tetrahydrofuryl)methyl]guanidine; Dinotefuran",,165252-70-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0033e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified as ""Not classified"" from (1).
-
-[Evidence Data]
-(1) It is reported that in a skin irritation test with rabbits (n = 6) (OECD TG 404, GLP, 4-hour application, 72-hour observation), very slight erythema was observed in 3 animals at 30 minutes after the removal of patches and one after 24 hours but fully disappeared after 48 hours (erythema/eschar score: 0/0/0/0/0/0.3, edema score: 0/0/0/0/0/0) (JMPR (2012), REACH registration dossier (Accessed Sep. 2020), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2018)).",Provided,JP_CHRIP,1,CNC(=N[N+](=O)[O-])NCC1CCOC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.067.656H,J-GLOBAL,CNC(=N[N+](=O)[O-])NCC1CCOC1,Train,1,2702,training
-"EU_CLP:
-(1-hydroxydodecylidene)diphosphonic acid",,16610-63-2,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCCCCCCCCCCC(O)(P(=O)(O)O)P(=O)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/4395717,PubChem,CCCCCCCCCCCC(O)(P(=O)(O)O)P(=O)(O)O,Test,1,2702,training
-"NZ_CCID:
-Malonyl dichloride",,1663-67-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AA6C7B98-3DE8-4579-8893-44387327F857,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(C(=O)Cl)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/74269,PubChem,O=C(Cl)CC(=O)Cl,Train,1,2702,training
-"EU_REACH:
-docosyl methacrylate",,16669-27-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20681/7/4/2/?documentUUID=dc913f52-456e-4844-96b6-92e6a9d2bedb,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCCCCCCCOC(=O)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/3034258,PubChem,C=C(C)C(=O)OCCCCCCCCCCCCCCCCCCCCCC,Train,1,2702,training
-"JP_CHRIP:
-Ethephon",,16672-87-0,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0056e.html,"JP_CHRIP:
-Because corrosive to this substance proven by spots of necrosis and edema in 4 out of 6 animals and contact erythema in 6 animals observed after an application of 0.5 mL of a water solution to rabbit skins for one to four hours was reported (JMPR 861 (1993)), and a pH about 1 of this substance was described (Sax (11th, 2004)), it was classified in Category 1.",,JP_CHRIP,1,OP(=O)(O)CCCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.864C,J-GLOBAL,O=P(O)(O)CCCl,Train,1,2702,training
-"EU_REACH:
-Phosphinic acid, P-[3-(acetyloxy)-3-cyanopropyl]-P-methyl-, butyl ester",,167004-78-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33703/7/4/2/?documentUUID=af43a141-1efb-4780-8579-e2446274c9e2,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOP(=O)(C)CCC(C#N)OC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/44145865,PubChem,CCCCOP(C)(=O)CCC(C#N)OC(C)=O,Train,1,2702,training
-"US_HSDB:
-2-(DIISOPROPYLAMINO)ETHYL METHACRYLATE",,16715-83-6,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/6090,,,US_HSDB,1,CC(C)N(CCOC(=O)C(=C)C)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/28003,PubChem,C=C(C)C(=O)OCCN(C(C)C)C(C)C,Train,1,2702,training
-"AU_HCIS:
-1-Hexadecanamine, N-hexadecyl-",,16724-63-3,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5775,,,AU_HCIS,1,CCCCCCCCCCCCCCCCNCCCCCCCCCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/85571,PubChem,CCCCCCCCCCCCCCCCNCCCCCCCCCCCCCCCC,Train,1,2702,training
-"EU_REACH:
-methyl (2E)-2-{2-[(2,5-dimethylphenoxy)methyl]phenyl}-2-(methoxyimino)acetate",,167374-38-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/3001/7/4/2/?documentUUID=57915678-b8b6-4599-b33e-1a748f35c6d5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)C)OCC2=CC=CC=C2/C(=N\OC)/C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/15346094,PubChem,CO/N=C(/C(=O)OC)c1ccccc1COc1cc(C)ccc1C,Train,1,2702,training
-"EU_CLP:
-bis-[4-(2,3-epoxipropoxi)phenyl]propane",,1675-54-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C)(C1=CC=C(C=C1)OCC2CO2)C3=CC=C(C=C3)OCC4CO4,https://pubchem.ncbi.nlm.nih.gov/compound/2286,PubChem,CC(C)(c1ccc(OCC2CO2)cc1)c1ccc(OCC2CO2)cc1,Test,1,2702,training
-"EU_CLP:
-[3-(chlorocarbonyl)-2-methylphenyl]acetate",,167678-46-8,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC1=C(C=CC=C1OC(=O)C)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7010345,PubChem,CC(=O)Oc1cccc(C(=O)Cl)c1C,Test,1,2702,training
-"JP_CHRIP:
-Ethylcyclohexane","JP_CHRIP:
-ethylcyclohexane",1678-91-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2085e.html,"JP_CHRIP:
-[Rationale for the Classification]
-Based on (1), it was classified as ""Not classified.""
-
-[Evidence Data]
-(1) In a skin irritation test with rabbits according to OECD TG 404, the mean scores at 24/48/72 hours were all 0 (REACH registration dossier (Access on October 2019)).",Provided,JP_CHRIP,1,CCC1CCCCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J43.538D,J-GLOBAL,CCC1CCCCC1,Train,1,2702,training
-"NZ_CCID:
-2-Propenoic acid, 1,2-ethanediylbis(oxy-2,1-ethanediyl) ester",,1680-21-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CF94804F-9CA8-4694-ACDF-7AC17664CF48,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,C=CC(=O)OCCOCCOCCOC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/62414,PubChem,C=CC(=O)OCCOCCOCCOC(=O)C=C,Train,1,2702,training
-"EU_REACH:
-dioctyl carbonate",,1680-31-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15695/7/4/2/?documentUUID=48a24014-6376-47af-9773-923c0d6e361a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCOC(=O)OCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/9904000,PubChem,CCCCCCCCOC(=O)OCCCCCCCC,Train,1,2702,training
-"NZ_CCID:
-2-Tetrahydrofuran carboxylic acid","NZ_CCID:
-tetrahydro-2-furoic acid",16874-33-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3D6E1095-7C05-4064-9177-91971EC9E225,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CC(OC1)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/86079,PubChem,O=C(O)C1CCCO1,Train,1,2702,training
-"NZ_CCID:
-3-Chloroacetylacetone","NZ_CCID:
-3-chloro-2,4-pentanedione",1694-29-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/67CA145C-1991-4E80-8E33-2F1995C2724F,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(=O)C(C(=O)C)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/74328,PubChem,CC(=O)C(Cl)C(C)=O,Train,1,2702,training
-"EU_REACH:
-3,3-dimethylbutyryl chloride",,1694-31-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19761/7/4/2/?documentUUID=be28c706-2489-4494-9c34-a3dddf7f9fec,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)CC(=O)OC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/15538,PubChem,CC(=O)CC(=O)OC(C)(C)C,Train,1,2702,training
-"EU_REACH:
-N-(2-ethylhexyl)-3,5,5-trimethylhexanamide",,1700656-13-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25255/7/4/2/?documentUUID=cf3d0bcb-e582-420a-a487-1dfbe0598e96,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)CNC(=O)CC(C)CC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/154734376,PubChem,CCCCC(CC)CNC(=O)CC(C)CC(C)(C)C,Train,1,2702,training
-"EU_REACH:
-3-{2,2,6,6-tetramethyl-4-[(trimethylsilyl)oxy]-3,5-dioxa-2,4,6-trisilaheptan-4-yl}propyl 2-methylprop-2-enoate",,17096-07-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23711/7/4/2/?documentUUID=fee2c1a3-d0f1-4cec-b4e5-5c8104689bf8,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OCCC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/123371,PubChem,C=C(C)C(=O)OCCC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C,Train,1,2702,training
-"NZ_CCID:
-3-Fluorobenzoyl chloride",,1711-07-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/937B3B2E-B785-480B-9E17-5A3E585C18AD,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)F)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/74376,PubChem,O=C(Cl)c1cccc(F)c1,Train,1,2702,training
-"NZ_CCID:
-3-Bromobenzoyl chloride",,1711-09-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E0E6A273-F72D-4F5E-A4B6-A3FE2D971A11,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC(=CC(=C1)Br)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/74377,PubChem,O=C(Cl)c1cccc(Br)c1,Train,1,2702,training
-"NZ_CCID:
-Dichlorodiethylsilane",,1719-53-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/180592D1-B3B7-4D90-8594-903EEA3BFF4A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC[Si](CC)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/15589,PubChem,CC[Si](Cl)(Cl)CC,Train,1,2702,training
-"NZ_CCID:
-Chloromethyldimethylchlorosilane","NZ_CCID:
-chloro(chloromethyl)dimethylsilane",1719-57-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6707F26B-1C8A-4A5C-A208-095EF77C8BA1,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C[Si](C)(CCl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/74393,PubChem,C[Si](C)(Cl)CCl,Train,1,2702,training
-"KR_NCIS:
-Chloroethenyldimethylsilane",,1719-58-0,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C[Si](C)(C=C)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/519368,PubChem,C=C[Si](C)(C)Cl,Train,1,2702,training
-"EU_REACH:
-4'-[(diphenoxyphosphoryl)oxy]-[1,1'-biphenyl]-4-yl diphenyl phosphate",,17270-01-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7393/7/4/2/?documentUUID=bc5e1914-9bf3-4efa-ac12-74a69001a9f6,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)OP(=O)(OC2=CC=CC=C2)OC3=CC=C(C=C3)C4=CC=C(C=C4)OP(=O)(OC5=CC=CC=C5)OC6=CC=CC=C6,https://pubchem.ncbi.nlm.nih.gov/compound/12039854,PubChem,O=P(Oc1ccccc1)(Oc1ccccc1)Oc1ccc(-c2ccc(OP(=O)(Oc3ccccc3)Oc3ccccc3)cc2)cc1,Train,1,2702,training
-"EU_REACH:
-(6-hydroxynaphthalen-2-yl)boronic acid",,173194-95-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7159/7/4/2/?documentUUID=c8ddcecd-5cb7-4fd8-972c-5ae9a1603e77,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,B(C1=CC2=C(C=C1)C=C(C=C2)O)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/4349738,PubChem,OB(O)c1ccc2cc(O)ccc2c1,Train,1,2702,training
-"AU_HCIS:
-1-Tetradecanamine, N-tetradecyl-",,17361-44-3,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5776,,,AU_HCIS,1,CCCCCCCCCCCCCCNCCCCCCCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/87077,PubChem,CCCCCCCCCCCCCCNCCCCCCCCCCCCCC,Train,1,2702,training
-"EU_REACH:
-(2-methylpropylidene)[(3-{[(2-methylpropylidene)amino]methyl}cyclohexyl)methyl]amine",,173904-11-5,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10659/7/4/2/?documentUUID=1a0a4d88-2e1e-49e5-b49b-f5b1940eda8e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C=NCC1CCCC(C1)CN=CC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/132472057,PubChem,CC(C)C=NCC1CCCC(CN=CC(C)C)C1,Train,1,2702,training
-"EU_REACH:
-2-methylbenzene-1,4-diyl bis{4-[3-(acryloyloxy)propoxy]benzoate}",,174063-87-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29950/7/4/2/?documentUUID=6ab5bfec-2f9e-4047-8fd2-06fa4d475b38,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=CC(=C1)OC(=O)C2=CC=C(C=C2)OCCCOC(=O)C=C)OC(=O)C3=CC=C(C=C3)OCCCOC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/20807398,PubChem,C=CC(=O)OCCCOc1ccc(C(=O)Oc2ccc(OC(=O)c3ccc(OCCCOC(=O)C=C)cc3)c(C)c2)cc1,Train,1,2702,training
-"EU_REACH:
-1-ethoxy-2,3-difluoro-4-[(1s,4r)-4-propylcyclohexyl]benzene",,174350-05-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22010/7/4/2/?documentUUID=b03e0835-e5a6-4dd7-9cde-27d5258675e0,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2=C(C(=C(C=C2)OCC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/19103501,PubChem,CCCC1CCC(c2ccc(OCC)c(F)c2F)CC1,Train,1,2702,training
-"EU_REACH:
-1-decene, dimer",,17438-89-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8881/7/4/2/?documentUUID=9cd8b6fc-263b-411c-97f9-6ec1b4470871,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCC(C)CCCCCCCCC=C,https://pubchem.ncbi.nlm.nih.gov/compound/22833390,PubChem,C=CCCCCCCCCC(C)CCCCCCCC,Train,1,2702,training
-"EU_REACH:
-prop-2-en-1-yl 2-(2-chloro-5-nitrobenzoyloxy)-2-methylpropanoate",,174489-76-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6005/7/4/2/?documentUUID=7e8d8941-f84f-424f-a6af-069713732699,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C(=O)OCC=C)OC(=O)C1=C(C=CC(=C1)[N+](=O)[O-])Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11782392,PubChem,C=CCOC(=O)C(C)(C)OC(=O)c1cc([N+](=O)[O-])ccc1Cl,Test,1,2702,training
-"NZ_CCID:
-2-Allylphenol",,1745-81-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4EBAEBCF-4296-43C2-B256-AF9086D8652C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C=CCC1=CC=CC=C1O,https://pubchem.ncbi.nlm.nih.gov/compound/15624,PubChem,C=CCc1ccccc1O,Train,1,2702,training
-"AU_HCIS:
-Phenol, 4,4'-(1-methylethylidene)bis[2-(2-propen-1-yl)-",,1745-89-7,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3454,,,AU_HCIS,1,CC(C)(C1=CC(=C(C=C1)O)CC=C)C2=CC(=C(C=C2)O)CC=C,https://pubchem.ncbi.nlm.nih.gov/compound/74457,PubChem,C=CCc1cc(C(C)(C)c2ccc(O)c(CC=C)c2)ccc1O,Train,1,2702,training
-"JP_CHRIP:
-2,3,7,8-tetrachlorodibenzo[b,e][1,4]dioxin
-
-US_HSDB:
-2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN","JP_CHRIP:
-2,3,7,8-TCDD
-2,3,7,8-Tetrachloro-1,4-dioxin
-2,3,7,8-Tetrachlorodibenzo-1,4-dioxine
-2,3,7,8-Tetrachlorodibenzo-p-dioxin
-2,3,7,8-Tetrachlorodibenzo-para-dioxin
-Dibenzo [b,e] [1,4]dioxin, 2,3,7,8-tetrachloro-
-Dibenzo[b,e][1,4]dioxin, 2,3,7,8-tetrachloro-
-Dioxin
-TCDD",1746-01-6,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0829e.html
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/4151","JP_CHRIP:
-From description that hyperkeratosis and epidermal hyperplasia were accepted in the acute dermatitis exposure tests using the mouse (ATSDR (1998)), and description that the skin was stimulated (ICSC (J) (2003)), it was set as Category 2.",,"JP_CHRIP, US_HSDB",2,Clc1cc2Oc3cc(Cl)c(Cl)cc3Oc2cc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.677C,J-GLOBAL,Clc1cc2c(cc1Cl)Oc1cc(Cl)c(Cl)cc1O2,Train,1,2702,training
-"EU_REACH:
-4-amino-N-(4-amino-6-oxo-5H-pyrimidin-2-yl)benzenesulfonamide",,174863-37-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21336/7/4/2/?documentUUID=47955e99-4209-49c5-9230-05b3ec16b723,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C(=N/C(=N\S(=O)(=O)C2=CC=C(C=C2)N)/NC1=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/154734778,PubChem,NC1=N/C(=N\S(=O)(=O)c2ccc(N)cc2)NC(=O)C1,Train,1,2702,training
-"AU_HCIS:
-1-Propanamine, N,N-dimethyl-3-(octadecyloxy)-",,17517-01-0,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3656,,,AU_HCIS,1,CCCCCCCCCCCCCCCCCCOCCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/87142,PubChem,CCCCCCCCCCCCCCCCCCOCCCN(C)C,Train,1,2702,training
-"EU_REACH:
-1-{5-[(dimethylcarbamoyl)amino]-2-methylphenyl}-3,3-dimethylurea",,17526-94-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12195/7/4/2/?documentUUID=e168413b-bde9-47e4-a819-5659befded08,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)NC(=O)N(C)C)NC(=O)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/87146,PubChem,Cc1ccc(NC(=O)N(C)C)cc1NC(=O)N(C)C,Train,1,2702,training
-"EU_REACH:
-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl prop-2-enoate",,17527-29-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15839/7/4/2/?documentUUID=c172a224-99fa-41ee-9fd0-f9c5617d6df9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CC(=O)OCCC(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/87149,PubChem,C=CC(=O)OCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train,1,2702,training
-"EU_REACH:
-3-phenyl-2-(undec-10-enamido)propanoic acid",,175357-18-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23617/7/4/2/?documentUUID=46a1e8f4-7984-45dc-828a-2221f2774f58,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CCCCCCCCCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/10308702,PubChem,C=CCCCCCCCCC(=O)N[C@@H](Cc1ccccc1)C(=O)O,Train,1,2702,training
-"JP_CHRIP:
-1,3-bis(2,3-epoxypropoxy)-2,2-dimethylpropane
-
-NZ_CCID:
-Neopentyl glycol diglycidyl ether","JP_CHRIP:
-1,3-bis(2,3-Epoxypropoxy)-2,2-dimethylpropane
-2,2'-(2,2-Dimethyl-1,3 propanediyl)bis(oxymethylene)bisoxirane
-2,2'-[(2,2-Dimethyl-1,3-propanediyl)bis(oxymethylene)]bis[oxirane]
-
-NZ_CCID:
-1,3-Bis(2,3-epoxypropoxy)-2,2-dimethylpropane, Propane, 1,3-bis(2,3-epoxypropoxy)-2,2-dimethyl-",17557-23-2,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0254e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6D390E32-66B6-44EF-BE22-40C0C998E818","JP_CHRIP:
-In Draize tests using rabbits, moderate irritation was measured and its Draize score was approximately 2.3 out of 8 (Patty (5th, 2001)). In addition, the substance was rated as R38 in the EU classification (equivalent to Category 2) (EU-Annex 1, accessed in December 2008). Based on these reports, the substance was classified into Category 2.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]
-Eye Irritation
-SPECIES:
-RESULT: Irritating
-REFERENCE SOURCE: [ICSC]",,"JP_CHRIP, NZ_CCID",2,CC(C)(COCC1CO1)COCC1CO1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J64.260F,J-GLOBAL,CC(C)(COCC1CO1)COCC1CO1,Train,1,2702,training
-"AU_HCIS:
-1,3-Diazetidine-2,4-dione, 1,3-bis[4-[(4-isocyanatophenyl)methyl]phenyl]-",,17589-24-1,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1206,,,AU_HCIS,1,C1=CC(=CC=C1CC2=CC=C(C=C2)N3C(=O)N(C3=O)C4=CC=C(C=C4)CC5=CC=C(C=C5)N=C=O)N=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/87165,PubChem,O=C=Nc1ccc(Cc2ccc(N3C(=O)N(c4ccc(Cc5ccc(N=C=O)cc5)cc4)C3=O)cc2)cc1,Train,1,2702,training
-"NZ_CCID:
-Cyclopropanecarboxylic acid",,1759-53-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9BE7C48D-3217-4B2E-BED8-C702045223CB,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CC1C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/15655,PubChem,O=C(O)C1CC1,Train,1,2702,training
-"EU_REACH:
-N-(3-(trimethoxysilyl)propyl)ethylenediamine",,1760-24-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15039/7/4/2/?documentUUID=02a7bb66-dbb2-444c-ab0d-344e7246e75d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CO[Si](CCCNCCN)(OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/15659,PubChem,CO[Si](CCCNCCN)(OC)OC,Train,1,2702,training
-"JP_CHRIP:
-4,4'-Methylenebis(cyclohexan-1-amine)
-
-NZ_CCID:
-Cyclohexanamine, 4,4'-methylenebis-","JP_CHRIP:
-Bis (4-aminocyclohexyl) methane
-
-NZ_CCID:
-Bis(4)aminocyclohexyl)methane, Bis(p–aminocyclohexyl)methane, Dicyclohexylmethane–4,4’–diamine",1761-71-3,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-0025e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E513BE0A-1513-427F-97F8-9EC909608C6F","JP_CHRIP:
-[Rationale for the Classification]
-Based on (1)-(3), it was classified in Category 1B-C.
-
-[Evidence Data]
-(1) In a skin irritation test with rabbits according to OECD TG 404, the 3-minute exposure did not result in necrosis at the 1-hour observation period, but one out of three animals exhibited necrosis at the 24-hour observation. The 2.75-hour exposure resulted in necrosis by the 1-hour post exposure observation (REACH registration dossier (Access on November 2019)).
-(2) This substance is considered to be severely irritating to corrosive to the skin and eyes (GESTIS (Access on September 2019)).
-(3) This substance is also considered to be corrosive since all of its analogues are corrosive substances (SIDS (2016)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Guinea pig
-RESULT: 10% and 5% solutions resulted in strong irritation to intact skin in young animals.
-REFERENCE SOURCE: http://yosemite.epa.gov/oppts/epatscat8.nsf/ReportSearchView/F6677772F9B9C1418525693100226A82
-REMARK: Strong irritant at 10% indicates more severe effect at higher concentration.
-
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Corrosive
-REFERENCE SOURCE: http://yosemite.epa.gov/oppts/epatscat8.nsf/ReportSearchView/03647C452583AA1985256930004CD220",Provided,"JP_CHRIP, NZ_CCID",2,NC1CCC(CC2CCC(N)CC2)CC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J47.629C,J-GLOBAL,NC1CCC(CC2CCC(N)CC2)CC1,Train,1,2702,training
-"EU_REACH:
-ethylsilanetriyl triacetate
-
-JP_CHRIP:
-Ethyltriacetoxysilane","JP_CHRIP:
-Ethyltriacetoxysilane; Ethyltriacetoxysilane",17689-77-9,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14224/7/4/2/?documentUUID=583ebd6f-e316-4a5c-9fec-774e43c3f640
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0042e.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-In a test by a 3-minute semi-occlusive application of 0.5 mL of undiluted this substance to the rabbit skin, severe lesions were observed 72 hours after the application in four out of six animals, and reversibility was slight during a 14-day observation period. And the primary dermal irritation index (PDII) was 4.28, and it was judged as corrosive (SIDS (2005)). Therefore, it was classified in Category 1.",Provided,"EU_REACH, JP_CHRIP",2,CC[Si](OC(=O)C)(OC(=O)C)OC(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J266.800I,J-GLOBAL,CC[Si](OC(C)=O)(OC(C)=O)OC(C)=O,Train,1,2702,training
-"EU_REACH:
-methyl [(2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl]carbamate",,176972-62-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6302/7/4/2/?documentUUID=fbab6cf7-3408-4a13-b48a-5c95fa1b187e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)N[C@@H](CC1=CC=CC=C1)[C@@H](CCl)O,https://pubchem.ncbi.nlm.nih.gov/compound/10945089,PubChem,COC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CCl,Train,1,2702,training
-"EU_REACH:
-2-methoxy-10H-phenothiazine",,1771-18-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18877/7/4/2/?documentUUID=d52ea796-139f-4ca5-9341-86f48d013d64,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC2=C(C=C1)SC3=CC=CC=C3N2,https://pubchem.ncbi.nlm.nih.gov/compound/74490,PubChem,COc1ccc2c(c1)Nc1ccccc1S2,Train,1,2702,training
-"EU_REACH:
-3-hydroxy-2-(3-hydroxyquinolin-2-yl)-1H-inden-1-one",,17772-51-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10225/7/4/2/?documentUUID=8c22e3cc-9c68-4c11-aa56-1a69e0807943,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C=C(C(=N2)C3=C(C4=CC=CC=C4C3=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/87299,PubChem,O=C1C(c2nc3ccccc3cc2O)=C(O)c2ccccc21,Train,1,2702,training
-"EU_REACH:
-2-hydroxy-4-(methylsulfanyl)butanenitrile",,17773-41-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10238/7/4/2/?documentUUID=214ac58e-4e8a-4cf5-ad08-a9d2d1560dbe,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CSCCC(C#N)O,https://pubchem.ncbi.nlm.nih.gov/compound/87302,PubChem,CSCCC(O)C#N,Test,1,2702,training
-"EU_REACH:
-(2,4-dichlorophenyl)methanol",,1777-82-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23988/7/4/2/?documentUUID=e7b4ba2b-332d-4986-ad52-6c3afd4e88a9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C=C1Cl)Cl)CO,https://pubchem.ncbi.nlm.nih.gov/compound/15684,PubChem,OCc1ccc(Cl)cc1Cl,Test,1,2702,training
-"EU_REACH:
-2-(2-{2-[2-(prop-2-enoyloxy)ethoxy]ethoxy}ethoxy)ethyl prop-2-enoate",,17831-71-9,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23295/7/4/2/?documentUUID=d03aaca4-aeae-4b0e-9b5f-b4d43589df0b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CC(=O)OCCOCCOCCOCCOC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/28803,PubChem,C=CC(=O)OCCOCCOCCOCCOC(=O)C=C,Train,1,2702,training
-"EU_REACH:
-9-Octadecenamide, N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl]-, (9Z)-",,178436-06-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24072/7/4/2/?documentUUID=2a18d699-2eed-4056-b1b5-be6ff166fd1b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCC[C@H]([C@H]([C@H](CO)NC(=O)CCCCCCC/C=C\CCCCCCCC)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/57378373,PubChem,CCCCCCCC/C=C\CCCCCCCC(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC,Train,1,2702,training
-"EU_REACH:
-cyclohexyldimethoxymethylsilane",,17865-32-6,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8528/7/4/2/?documentUUID=0b6466f6-6f30-40b9-b68f-444ab2380483,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CO[Si](C)(C1CCCCC1)OC,https://pubchem.ncbi.nlm.nih.gov/compound/569301,PubChem,CO[Si](C)(OC)C1CCCCC1,Train,1,2702,training
-"EU_REACH:
-Pentaerythritoltetracyanoacetic ester",,178671-69-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12629/7/4/2/?documentUUID=5a0e01a6-c304-49f2-a55d-0587150dd0c9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(C#N)C(=O)OCC(COC(=O)CC#N)(COC(=O)CC#N)COC(=O)CC#N,https://pubchem.ncbi.nlm.nih.gov/compound/6850853,PubChem,N#CCC(=O)OCC(COC(=O)CC#N)(COC(=O)CC#N)COC(=O)CC#N,Train,1,2702,training
-"NZ_CCID:
-Trimethyl(phenylthiomethyl)silane","NZ_CCID:
-(phenylthiomethyl)trimethylsilane",17873-08-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E36F9A61-DF24-4A9D-A1EC-0A848783E870,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C[Si](C)(C)CSC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/140295,PubChem,C[Si](C)(C)CSc1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-Dichloroethylsilane","JP_CHRIP:
-Ethyldichlorosilane",1789-58-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0089e.html,"JP_CHRIP:
-The substance is a severe irritant to skin (HSDB (2003)). Application of chlorosilanes to the skin of rabbits resulted in blanches and blisters in the treated area and the action was more marked the damper surface of skin (HSDB (2003)). The substance was classified into Category 1.",,JP_CHRIP,1,CC[SiH](Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J36.476B,J-GLOBAL,CC[SiH](Cl)Cl,Train,1,2702,training
-"EU_CLP:
-3-chloro-2-(isopropylthio)aniline",,179104-32-6,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C)SC1=C(C=CC=C1Cl)N,https://pubchem.ncbi.nlm.nih.gov/compound/2735747,PubChem,CC(C)Sc1c(N)cccc1Cl,Test,1,2702,training
-"EU_CLP:
-1-(3-methoxypropyl)-4-piperidinamine",,179474-79-4,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,COCCCN1CCC(CC1)N,https://pubchem.ncbi.nlm.nih.gov/compound/12088093,PubChem,COCCCN1CCC(N)CC1,Test,1,2702,training
-"EU_REACH:
-2,2,4,6,6-pentamethyl-4-octyl-3,5-dioxa-2,4,6-trisilaheptane",,17955-88-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21797/7/4/2/?documentUUID=e25caba2-0aa8-472a-845a-a45b03825cdb,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCC[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/87373,PubChem,CCCCCCCC[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C,Train,1,2702,training
-"EU_CLP:
-triethoxyisobutylsilane",,17980-47-1,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCO[Si](CC(C)C)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/87391,PubChem,CCO[Si](CC(C)C)(OCC)OCC,Test,1,2702,training
-"EU_REACH:
-5,7-Di-t-butyl-3-[3,5-dimethyl-4-[(1,3,7,9-tetra-t-butyl-5-methyl-5H-benzo[d][1,3,2]benzodioxaphosphocin-11-yl)oxy]phenyl]-3H-benzofuran-2-one",,1803088-15-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21782/7/4/2/?documentUUID=bd1483e8-618e-4800-9977-cce71a4ccf98,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1C2=C(C(=CC(=C2)C(C)(C)C)C(C)(C)C)OP(OC3=C1C=C(C=C3C(C)(C)C)C(C)(C)C)OC4=C(C=C(C=C4C)C5C6=C(C(=CC(=C6)C(C)(C)C)C(C)(C)C)OC5=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/118320794,PubChem,Cc1cc(C2C(=O)Oc3c2cc(C(C)(C)C)cc3C(C)(C)C)cc(C)c1OP1Oc2c(cc(C(C)(C)C)cc2C(C)(C)C)C(C)c2cc(C(C)(C)C)cc(C(C)(C)C)c2O1,Train,1,2702,training
-"AU_HCIS:
-Phenol, 4-octyl-",,1806-26-4,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5803,,,AU_HCIS,1,CCCCCCCCC1=CC=C(C=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/15730,PubChem,CCCCCCCCc1ccc(O)cc1,Train,1,2702,training
-"JP_CHRIP:
-3-(4-tert-Butylphenyl)propanal",,18127-01-0,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0008e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified in Category 2 from (1), (2).
-
-[Evidence Data]
-(1) It is reported that in a skin irritation test with rabbits (n = 6) (open, 72-hour application, 72-hour observation), focal hemorrhages, slight to distinct ischemia and incrustation, and very slight edema were observed, and severe skin irritation was seen (REACH registration dossier (Accessed May 2020)).
-(2) It is reported that in an in-vitro skin irritation test (OECD TG 439), cell viability, R = 19.5% (REACH registration dossier (Accessed May 2020)).",,JP_CHRIP,1,CC(C)(C)c1ccc(CCC=O)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J260.882K,J-GLOBAL,CC(C)(C)c1ccc(CCC=O)cc1,Train,1,2702,training
-"EU_REACH:
-(chloromethyl)(methoxy)dimethylsilane",,18143-33-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1316/7/4/2/?documentUUID=249cb383-0192-4cfd-a259-c958aaa66050,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CO[Si](C)(C)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/560623,PubChem,CO[Si](C)(C)CCl,Train,1,2702,training
-"EU_REACH:
-5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-(ethanesulfinyl)-1H-pyrazole-3-carbonitrile
-
-JP_CHRIP:
-5-Amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-ethylsulfinyl-1H-pyrazole-3-carbonitrile [ethiprole]","JP_CHRIP:
-Ethiprole",181587-01-9,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5874/7/4/2/?documentUUID=c6528b1b-8fee-49fc-aff8-a816b05de647
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-meti-0010e.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-It is reported that in a skin irritation test using rabbits applied 500 mg this substance, it was not irritating due to no skin reaction observed during a 72-hour observation period (Pesticide abstract (2015); Pesticide evaluation report, Food Safety Commission of Japan (2014)). From the above, the substance was classified as ""Not classified.""",Provided,"EU_REACH, JP_CHRIP",2,CCS(=O)c1c(N)n(nc1C#N)c1c(Cl)cc(cc1Cl)C(F)(F)F,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.979.586A,J-GLOBAL,CCS(=O)c1c(C#N)nn(-c2c(Cl)cc(C(F)(F)F)cc2Cl)c1N,Train,1,2702,training
-"EU_REACH:
-tert-butyl(chloro)dimethylsilane
-
-NZ_CCID:
-Silane, t-butylchlorodimethyl-","NZ_CCID:
-tert-Butyldimethylchlorosilane, tert-butyldimethylsilyl chloride",18162-48-6,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/28118/7/4/2/?documentUUID=143e28ba-806d-4c4a-bc42-d80292321842
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0E55EE36-D961-4EAA-A049-E58C4527B235","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",Provided,"EU_REACH, NZ_CCID",2,CC(C)(C)[Si](C)(C)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/28928,PubChem,CC(C)(C)[Si](C)(C)Cl,Train,1,2702,training
-"EU_REACH:
-4-{[diethoxy(methyl)silyl]methyl}morpholine",,18162-75-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20090/7/4/2/?documentUUID=22c5b67a-0a58-4d1a-94e4-15e557c12a8a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](C)(CN1CCOCC1)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/23065785,PubChem,CCO[Si](C)(CN1CCOCC1)OCC,Train,1,2702,training
-"NZ_CCID:
-2-Oxo-N-valeric acid",,1821-02-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/42E0C7E6-56A7-4E72-8EE4-980ADD411F81,,,NZ_CCID,1,CCCC(=O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/74563,PubChem,CCCC(=O)C(=O)O,Train,1,2702,training
-"EU_REACH:
-9,9-bis(methoxymethyl)-9H-fluorene",,182121-12-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26973/7/4/2/?documentUUID=fc1be520-0fcb-464c-9e77-28eae3cddf08,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COCC1(C2=CC=CC=C2C3=CC=CC=C31)COC,https://pubchem.ncbi.nlm.nih.gov/compound/11054211,PubChem,COCC1(COC)c2ccccc2-c2ccccc21,Train,1,2702,training
-"EU_CLP:
-bis(1-methylethyl)-dimethoxysilane",,18230-61-0,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C)[Si](C(C)C)(OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/87520,PubChem,CO[Si](OC)(C(C)C)C(C)C,Test,1,2702,training
-"NZ_CCID:
-2-Amino-6-methylpyridine",,1824-81-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F84584C6-C25C-41B3-9AE1-D88948AEAEAE,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=NC(=CC=C1)N,https://pubchem.ncbi.nlm.nih.gov/compound/15765,PubChem,Cc1cccc(N)n1,Train,1,2702,training
-"NZ_CCID:
-Ethoxytrimethylsilane",,1825-62-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/390FCA32-DD08-47E9-8290-6017B1E04640,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCO[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/15772,PubChem,CCO[Si](C)(C)C,Train,1,2702,training
-"NZ_CCID:
-Bis(trimethylsilyl) sulphate",,18306-29-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8D4A9ADF-9002-4B9E-8F37-5D75E4EF4D55,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C[Si](C)(C)OS(=O)(=O)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/87573,PubChem,C[Si](C)(C)OS(=O)(=O)O[Si](C)(C)C,Train,1,2702,training
-"EU_REACH:
-5-bromo-1H-pyrrolo[2,3-b]pyridine",,183208-35-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6677/7/4/2/?documentUUID=0aa0f16c-0959-4058-b1ce-9f149f5cba5f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CNC2=NC=C(C=C21)Br,https://pubchem.ncbi.nlm.nih.gov/compound/10307932,PubChem,Brc1cnc2[nH]ccc2c1,Train,1,2702,training
-"JP_CHRIP:
-2,4-Dichlorophenyl 4-nitrophenyl ether; Nitrofen","JP_CHRIP:
-2,4-Dichloro-1-(4-nitrophenoxy) benzene
-2,4-dichlorophenyl 4'-nitrophenyl ether
-2,4-dichlorophenyl 4'nitrophenyl ether
-2,4-Dichlorophenyl p-nitrophenyl ether
-2,4-Dichlorophenyl-p-nitrophenyl ether
-Niclofen
-Nitrofen (technical-grade)",1836-75-5,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/07-mhlw-0095e.html,"JP_CHRIP:
-This substance has been reported to have irritating effects on the skin and eyes of people with occupational exposure (PDS (1996)). Thus, it was classified into Category 2.",,JP_CHRIP,1,[O-][N+](=O)c1ccc(Oc2ccc(Cl)cc2Cl)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J31.991K,J-GLOBAL,O=[N+]([O-])c1ccc(Oc2ccc(Cl)cc2Cl)cc1,Train,1,2702,training
-"EU_CLP:
-2-chloro-5-methyl-pyridine",,18368-64-4,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC1=CN=C(C=C1)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/581393,PubChem,Cc1ccc(Cl)nc1,Test,1,2702,training
-"EU_REACH:
-trimethoxy(2-methylpropyl)silane",,18395-30-7,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13728/7/4/2/?documentUUID=86943322-770d-4099-b5ce-0a73a4897755,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C[Si](OC)(OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/87622,PubChem,CO[Si](CC(C)C)(OC)OC,Train,1,2702,training
-"NZ_CCID:
-Dichlorobis(1,1-dimethylethyl)silane","NZ_CCID:
-di-tert-butyldichlorosilane",18395-90-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BE5FB3CC-8FA1-4C5D-879D-B3725E8E8C8D,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)(C)[Si](C(C)(C)C)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/87624,PubChem,CC(C)(C)[Si](Cl)(Cl)C(C)(C)C,Train,1,2702,training
-"EU_REACH:
-(3E)-dec-3-en-2-one",,18402-84-1,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30007/7/4/2/?documentUUID=f53eae45-d619-4a9b-ad13-d9afac5d256d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCC/C=C/C(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/5363233,PubChem,CCCCCC/C=C/C(C)=O,Train,1,2702,training
-"EU_REACH:
-3,7-dimethyloct-6-en-3-ol",,18479-51-1,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20289/7/4/2/?documentUUID=636dac19-1abc-4196-bd6c-1ed74f485f48,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)(CCC=C(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/86749,PubChem,CCC(C)(O)CCC=C(C)C,Test,1,2702,training
-"EU_REACH:
-3-hydroxy-2-(hydroxymethyl)-2-methylpropanal",,18516-18-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19735/7/4/2/?documentUUID=fa614022-8234-44a8-9868-a3e403bf9b51,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CO)(CO)C=O,https://pubchem.ncbi.nlm.nih.gov/compound/87688,PubChem,CC(C=O)(CO)CO,Train,1,2702,training
-"NZ_CCID:
-(R)-(+)-1,1'-Binaphthyl-2,2'-diol",,18531-94-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3F011FCE-E16E-4046-ABD0-0CAC0E7BBE88,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C2C(=C1)C=CC(=C2C3=C(C=CC4=CC=CC=C43)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/11762,PubChem,Oc1ccc2ccccc2c1-c1c(O)ccc2ccccc12,Train,1,2702,training
-"EU_REACH:
-1,3-Bis(3-methacryloyloxypropyl)-1,1,3,3-tetramethyldisiloxane",,18547-93-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24123/7/4/2/?documentUUID=1183efc3-dff6-4de1-b208-0b34a25af5ee,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OCCC[Si](C)(C)O[Si](C)(C)CCCOC(=O)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/87703,PubChem,C=C(C)C(=O)OCCC[Si](C)(C)O[Si](C)(C)CCCOC(=O)C(=C)C,Train,1,2702,training
-"EU_REACH:
-(3R,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diyl bis(4-hydroxybenzoate)",,185756-31-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21447/7/4/2/?documentUUID=16367ca7-0006-4c25-aecc-9625ec38bee8,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1[C@H]([C@@H]2[C@H](O1)[C@H](CO2)OC(=O)C3=CC=C(C=C3)O)OC(=O)C4=CC=C(C=C4)O,https://pubchem.ncbi.nlm.nih.gov/compound/18664186,PubChem,O=C(O[C@H]1CO[C@H]2[C@@H]1OC[C@H]2OC(=O)c1ccc(O)cc1)c1ccc(O)cc1,Train,1,2702,training
-"JP_CHRIP:
-N-Butyl-2,6-dinitro-N-ethyl-4-trifluoromethylaniline; Benfluralin",,1861-40-1,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0058e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified in Category 2 from (1) - (3).
-
-[Evidence Data]
-(1) It is reported that in a skin irritation test with rabbits (n = 6) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 14-day observation), erythema persisted for 15 days in 3 animals (erythema/eschar score: 1/2/1.7/2/2/2, edema score: 1/1/1/1/1/1.3) (CLH Report (2019)).
-(2) It is reported that in a skin irritation test with rabbits (n = 6) (OECD TG 404, GLP, 4-hour application, 9-day observation), scaliness was observed in 5 animals after 9 days (erythema/eschar score: 0/0/0.3/0.7/0.7/0.3, edema score: 0.7/0.3/1/2/0.3/1.3) (CLH Report (2019)).
-(3) Moderate irritation was seen in a skin irritation test with rabbits (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2019), EPA Pesticides RED (2004)).",Provided,JP_CHRIP,1,CCCCN(CC)c1c(cc(cc1[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.786H,J-GLOBAL,CCCCN(CC)c1c([N+](=O)[O-])cc(C(F)(F)F)cc1[N+](=O)[O-],Train,1,2702,training
-"EU_CLP:
-6-dimethylaminohexan-1-ol",,1862-07-3,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CN(C)CCCCCCO,https://pubchem.ncbi.nlm.nih.gov/compound/74623,PubChem,CN(C)CCCCCCO,Test,1,2702,training
-"AU_HCIS:
-2-Propenoic acid, 3-phenyl-, 2-propenyl ester",,1866-31-5,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6593,,,AU_HCIS,1,C=CCOC(=O)/C=C/C1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/641423,PubChem,C=CCOC(=O)/C=C/c1ccccc1,Train,1,2702,training
-"EU_REACH:
-2-(trifluoromethyl)benzene-1-sulfonamide",,1869-24-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12574/7/4/2/?documentUUID=e3c2e575-15e8-477e-ba38-fd3f97599ae9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=C1)C(F)(F)F)S(=O)(=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/2778018,PubChem,NS(=O)(=O)c1ccccc1C(F)(F)F,Train,1,2702,training
-"EU_REACH:
-1,1,1,3,5,5,5-heptamethyltrisiloxane",,1873-88-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15810/7/4/2/?documentUUID=cb577c52-579c-4f34-bfd5-9c75fe36d75e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](O[Si](C)(C)C)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6327366,PubChem,C[Si](O[Si](C)(C)C)O[Si](C)(C)C,Train,1,2702,training
-"EU_REACH:
-5-[(2-ethylhexyl)oxy]-2-(4-{4-[(2-ethylhexyl)oxy]-2-hydroxyphenyl}-6-(4-methoxyphenyl)-1,3,5-triazin-2-yl)phenol",,187393-00-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12265/7/4/2/?documentUUID=cf8c8081-e7b9-4ef5-9fb1-63f49163a1d3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC1=CC(=C(C=C1)C2=NC(=NC(=N2)C3=CC=C(C=C3)OC)C4=C(C=C(C=C4)OCC(CC)CCCC)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/135487856,PubChem,CCCCC(CC)COc1ccc(-c2nc(-c3ccc(OC)cc3)nc(-c3ccc(OCC(CC)CCCC)cc3O)n2)c(O)c1,Train,1,2702,training
-"EU_REACH:
-trimethyl(octadecyloxy)silane",,18748-98-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23563/7/4/2/?documentUUID=78329cad-8534-42c7-ad10-e2bfa4427a35,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCCCO[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/87778,PubChem,CCCCCCCCCCCCCCCCCCO[Si](C)(C)C,Train,1,2702,training
-"EU_REACH:
-dimethyl propylphosphonate",,18755-43-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13875/7/4/2/?documentUUID=e1c6f3d3-b2a6-42fe-9e27-3e411622debc,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCP(=O)(OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/87779,PubChem,CCCP(=O)(OC)OC,Train,1,2702,training
-"EU_REACH:
-2-methyl-4-[4-({[4-(prop-2-enoyloxy)butoxy]carbonyl}oxy)benzoyloxy]phenyl 4-({[4-(prop-2-enoyloxy)butoxy]carbonyl}oxy)benzoate",,187585-64-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23898/7/4/2/?documentUUID=51944794-9b43-4fe2-94d5-4e497497d017,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=CC(=C1)OC(=O)C2=CC=C(C=C2)OC(=O)OCCCCOC(=O)C=C)OC(=O)C3=CC=C(C=C3)OC(=O)OCCCCOC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/21351348,PubChem,C=CC(=O)OCCCCOC(=O)Oc1ccc(C(=O)Oc2ccc(OC(=O)c3ccc(OC(=O)OCCCCOC(=O)C=C)cc3)c(C)c2)cc1,Train,1,2702,training
-"EU_CLP:
-3-methylaminomethylphenylamine",,18759-96-1,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CNCC1=CC(=CC=C1)N,https://pubchem.ncbi.nlm.nih.gov/compound/11643936,PubChem,CNCc1cccc(N)c1,Test,1,2702,training
-"EU_REACH:
-tetrakis(2-butoxyethyl) orthosilicate",,18765-38-3,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22946/7/4/2/?documentUUID=c4c70cfb-14cd-4ca9-90a1-bc699c81cb96,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOCCO[Si](OCCOCCCC)(OCCOCCCC)OCCOCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/87781,PubChem,CCCCOCCO[Si](OCCOCCCC)(OCCOCCCC)OCCOCCCC,Train,1,2702,training
-"NZ_CCID:
-4-Chlorophenylacetic acid",,1878-66-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/02FD0868-B586-475D-BFD3-1C2CAC73805E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1CC(=O)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/15880,PubChem,O=C(O)Cc1ccc(Cl)cc1,Train,1,2702,training
-"NZ_CCID:
-4-Bromophenylacetic acid",,1878-68-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5657FFDD-0123-46D3-AF6D-13C2DD543720,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1CC(=O)O)Br,https://pubchem.ncbi.nlm.nih.gov/compound/74654,PubChem,O=C(O)Cc1ccc(Br)cc1,Train,1,2702,training
-"EU_REACH:
-trans,trans-2,3',4',5'-Tetrafluor-4-(4'-propylbicyclohexyl-4 -yl)-biphenyl",,188289-44-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23357/7/4/2/?documentUUID=08eb0082-8954-42d1-bd86-499c14454979,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2CCC(CC2)C3=CC(=C(C=C3)C4=CC(=C(C(=C4)F)F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/15389837,PubChem,CCCC1CCC(C2CCC(c3ccc(-c4cc(F)c(F)c(F)c4)c(F)c3)CC2)CC1,Train,1,2702,training
-"NZ_CCID:
-Phenyl chloroformate",,1885-14-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6A1312A0-0743-4E01-B9AB-3AB6275024D3,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 41 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)OC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/15891,PubChem,O=C(Cl)Oc1ccccc1,Train,1,2702,training
-"EU_REACH:
-hex-3-en-1-yl cyclopropanecarboxylate",,188570-78-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/9542/7/4/2/?documentUUID=dec687cc-0187-4e71-ba19-77e80f25cff9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC/C=C\CCOC(=O)C1CC1,https://pubchem.ncbi.nlm.nih.gov/compound/44152604,PubChem,CC/C=C\CCOC(=O)C1CC1,Test,1,2702,training
-"NZ_CCID:
-Hexachloropropene",,1888-71-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C38BC956-CD30-4E79-A397-92918DD42AED,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(=C(Cl)Cl)(C(Cl)(Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/15902,PubChem,ClC(Cl)=C(Cl)C(Cl)(Cl)Cl,Train,1,2702,training
-"EU_REACH:
-1-acetylazepan-2-one",,1888-91-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25718/7/4/2/?documentUUID=8726885f-a2aa-440e-8593-dbf8b2526923,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)N1CCCCCC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/15904,PubChem,CC(=O)N1CCCCCC1=O,Train,1,2702,training
-"EU_REACH:
-(2,3-dimethyl-3-phenylbutan-2-yl)benzene",,1889-67-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13835/7/4/2/?documentUUID=4e9615b9-7ea0-464f-b3ab-fadfacb307c5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C1=CC=CC=C1)C(C)(C)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/74681,PubChem,CC(C)(c1ccccc1)C(C)(C)c1ccccc1,Train,1,2702,training
-"EU_REACH:
-N-(2-(dimethylamino)ethoxy)ethyl)-N-methyl-1,3-propanediamine",,189253-72-3,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5264/7/4/2/?documentUUID=255b8037-a3c5-471e-baa4-9d6116a6a019,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C)CCOCCN(C)CCCN,https://pubchem.ncbi.nlm.nih.gov/compound/18945537,PubChem,CN(C)CCOCCN(C)CCCN,Train,1,2702,training
-"EU_REACH:
-4-ethoxy-2,3-difluoro-4'-(trans-4-propylcyclohexyl)-1,1'-biphenyl",,189750-98-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24125/7/4/2/?documentUUID=714e318a-1eb0-4ea3-bf77-20d21dbc1c8d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2=CC=C(C=C2)C3=C(C(=C(C=C3)OCC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/18681376,PubChem,CCCC1CCC(c2ccc(-c3ccc(OCC)c(F)c3F)cc2)CC1,Train,1,2702,training
-"EU_REACH:
-methyl (2E)-2-[2-(chloromethyl)phenyl]-2-(methoxyimino)acetate",,189813-45-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/4529/7/4/2/?documentUUID=5819b56c-0567-46dd-8617-5d99228dfd26,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)/C(=N/OC)/C1=CC=CC=C1CCl,https://pubchem.ncbi.nlm.nih.gov/compound/11806789,PubChem,CO/N=C(/C(=O)OC)c1ccccc1CCl,Train,1,2702,training
-"EU_CLP:
-4,4-dimethoxybutylamine",,19060-15-2,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,COC(CCCN)OC,https://pubchem.ncbi.nlm.nih.gov/compound/5463803,PubChem,COC(CCCN)OC,Test,1,2702,training
-"NZ_CCID:
-Dicamba acid","NZ_CCID:
-3,6-dichloro-o-anisic acid, Benzoic acid, 3,6-dichloro-2-methoxy-, Dicamba",1918-00-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F9EE3853-E3A5-4A06-B2A6-B48C84640B78,"NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Moderately irritating
-REFERENCE SOURCE: [Pesticide Manual, 11th Edition]
-Eye Irritation
-R-PHRASE: R 41. [N-CLASS]",,NZ_CCID,1,COC1=C(C=CC(=C1C(=O)O)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/3030,PubChem,COc1c(Cl)ccc(Cl)c1C(=O)O,Train,1,2702,training
-"NZ_CCID:
-Propachlor","NZ_CCID:
-Acetamide, 2-chloro-N-(1-methylethyl)-N-phenyl-, Acetanilide, 2-chloro-N-isopropyl-, 2-Chloro-N-(1-methylethyl)-N-phenylacetamide",1918-16-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DE3C27B9-F767-4F39-BE02-F7B221FDAE44,"NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: For technical propachlor (94.5% pure) a slight degree of dermal irritation was observed (2.5/8.0 score) (Braun et al., 1979a); for a 20% formulation of propachlor (again 94.5% pure) there was a slight degree of dermal irritation (1.8/8.0 score) (Braun et al., 1979b); for a 65% formulation a moderate degree of dermal irritation (3.4/8.0 score) (Braun et al., 1979c); and for a 42% formulation corrosive effects were observed (Branch et al., 1982b).
-REFERENCE SOURCE: [INCHEM EHC 147]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Severe irritant.
-REFERENCE SOURCE: [REDS]",,NZ_CCID,1,CC(C)N(C1=CC=CC=C1)C(=O)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/4931,PubChem,CC(C)N(C(=O)CCl)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-Pristane
-
-US_HSDB:
-Pristane","NZ_CCID:
-Pentadecane, 2,6,10,14-tetramethyl-",1921-70-6,Cat 2,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B7F2D8B8-2BC9-403A-B4F8-B45A313B25A1
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8345","NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]",,"NZ_CCID, US_HSDB",2,CC(C)CCCC(C)CCCC(C)CCCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/15979,PubChem,CC(C)CCCC(C)CCCC(C)CCCC(C)C,Train,1,2702,training
-"NZ_CCID:
-5-Chloro-2-methylbenzoxazole",,19219-99-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F9F60FFE-4521-47AE-935A-3F9AA7695445,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=NC2=C(O1)C=CC(=C2)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/29510,PubChem,Cc1nc2cc(Cl)ccc2o1,Train,1,2702,training
-"EU_REACH:
-diethyl N-[3-(trimethoxysilyl)propyl]aspartate",,192389-48-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15828/7/4/2/?documentUUID=2861967d-94ab-4b61-ae49-910f0e371add,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C[C@@H](C(=O)OCC)NCCC[Si](OC)(OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/15390519,PubChem,CCOC(=O)C[C@H](NCCC[Si](OC)(OC)OC)C(=O)OCC,Train,1,2702,training
-"JP_CHRIP:
-2-Chloro-6-trichloromethylpyridine; Nitrapyrin","JP_CHRIP:
-2-Chloro-6-trichloromethylpyridine
-alpha,alpha,alpha,6-Tetrachloro-2-picoline
-Nitrapyrin",1929-82-4,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2052e.html,"JP_CHRIP:
-[Rationale for the Classification]
-Based on (1), it was classified as ""Not classified."" The category was changed due to new data obtained.
-
-[Evidence Data]
-(1) In a skin irritation test with rabbits according to OECD TG 404 and EPA OPPTS 870.2500, mean scores at 24/48/72 hours were all less than 2.3 (REACH registration dossier (Access on September 2019), EPA Pesticide (2005), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2007)).",Provided,JP_CHRIP,1,Clc1cccc(n1)C(Cl)(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.789B,J-GLOBAL,Clc1cccc(C(Cl)(Cl)Cl)n1,Train,1,2702,training
-"EU_REACH:
-(2Z)-4-(tert-butylperoxy)-4-oxobut-2-enoic acid",,1931-62-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26777/7/4/2/?documentUUID=64144a65-a429-49e8-91d6-6110dc0665a2,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)OOC(=O)/C=C\C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/5702664,PubChem,CC(C)(C)OOC(=O)/C=C\C(=O)O,Train,1,2702,training
-"EU_REACH:
-3-[(2-hydroxyethyl)amino]propan-1-ol",,19344-29-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17126/7/4/2/?documentUUID=47e520e7-623b-4a24-aa7f-482e679fdfdc,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CNCCO)CO,https://pubchem.ncbi.nlm.nih.gov/compound/3015059,PubChem,OCCCNCCO,Train,1,2702,training
-"NZ_CCID:
-Phenylmethanesulphonyl chloride",,1939-99-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E87D9517-685E-44FF-9405-4F58B89DDB8B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)CS(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/74740,PubChem,O=S(=O)(Cl)Cc1ccccc1,Train,1,2702,training
-"EU_REACH:
-3-amino-p-toluamide",,19406-86-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10821/7/4/2/?documentUUID=5c4aec55-a73b-4378-84cd-332a37c3b4a8,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)C(=O)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/88043,PubChem,Cc1ccc(C(N)=O)cc1N,Train,1,2702,training
-"EU_CLP:
-2-phenylethylisocyanate",,1943-82-4,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC=C(C=C1)CCN=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/160602,PubChem,O=C=NCCc1ccccc1,Test,1,2702,training
-"NZ_CCID:
-t-Butylhydroquinone
-
-US_HSDB:
-T-BUTYLHYDROQUINONE","NZ_CCID:
-t-Butyl hydroquinone",1948-33-0,Cat 2,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2CE2BB5A-9B6C-447B-8BB5-9006A26FF21F
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/838","NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit & Guinea Pig
-RESULT: Irritating.
-REFERENCE SOURCE: (Tert-butyl hydroquinone Authors: BIBRA working group Source: TA:Toxicity profile. The British Industrial Biological Research Association PG:3 p YR:89 IP: VI:) [TOXLINE]
-Eye Irritation
-SPECIES:
-RESULT: Irritating
-REFERENCE SOURCE: [NTP]",,"NZ_CCID, US_HSDB",2,CC(C)(C)C1=C(C=CC(=C1)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/16043,PubChem,CC(C)(C)c1cc(O)ccc1O,Train,1,2702,training
-"EU_CLP:
-1-methyltrimethylene diacrylate; 1,3-butylene glycol diacrylate",,19485-03-1,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(CCOC(=O)C=C)OC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/29635,PubChem,C=CC(=O)OCCC(C)OC(=O)C=C,Test,1,2702,training
-"EU_REACH:
-3-amino-4-chlorobenzamide",,19694-10-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10384/7/4/2/?documentUUID=ef08f183-ace8-4471-bf89-91fb8e6c0691,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C=C1C(=O)N)N)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/88200,PubChem,NC(=O)c1ccc(Cl)c(N)c1,Train,1,2702,training
-"NZ_CCID:
-2-Pyrazinecarbonitril","NZ_CCID:
-pyrazinecarbonitrile",19847-12-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6341C7C2-2C27-4480-8124-371EB6DCBCC8,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CN=C(C=N1)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/73172,PubChem,N#Cc1cnccn1,Train,1,2702,training
-"EU_REACH:
-3-methyl-5-phenylmethoxy-2-(4-phenylmethoxyphenyl)-1H-indole",,198479-63-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17867/7/4/2/?documentUUID=49c5c68c-87aa-4124-ad4b-eee46ab7e768,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(NC2=C1C=C(C=C2)OCC3=CC=CC=C3)C4=CC=C(C=C4)OCC5=CC=CC=C5,https://pubchem.ncbi.nlm.nih.gov/compound/3824745,PubChem,Cc1c(-c2ccc(OCc3ccccc3)cc2)[nH]c2ccc(OCc3ccccc3)cc12,Train,1,2702,training
-"EU_REACH:
-1-[4-(2-Azepan-1-yl-ethoxy)-benzyl]-5-(benzyloxy)-2(benzyloxyphenyl)-3-methyl-1H-indole",,198480-21-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17891/7/4/2/?documentUUID=78e5c0a5-62eb-4afc-a420-096f882df50e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(N(C2=C1C=C(C=C2)OCC3=CC=CC=C3)CC4=CC=C(C=C4)OCCN5CCCCCC5)C6=CC=C(C=C6)OCC7=CC=CC=C7,https://pubchem.ncbi.nlm.nih.gov/compound/9895831,PubChem,Cc1c(-c2ccc(OCc3ccccc3)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(OCc3ccccc3)cc12,Train,1,2702,training
-"EU_REACH:
-tert-butyl 2-{(2S,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-4-phenylbutyl}-2-[4-(pyridin-2-yl)benzyl]hydrazinecarboxylate",,198904-86-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20798/7/4/2/?documentUUID=79198bff-80b3-492e-9c3a-5fca6013fcdf,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)OC(=O)N[C@@H](CC1=CC=CC=C1)[C@H](CN(CC2=CC=C(C=C2)C3=CC=CC=N3)NC(=O)OC(C)(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/12084688,PubChem,CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2ccccn2)cc1)NC(=O)OC(C)(C)C,Train,1,2702,training
-"EU_REACH:
-7-ethoxy-2,2,7-trimethyl-3-(trimethylsilyl)-8-oxa-3-aza-2,7-disiladecane",,201290-01-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20966/7/4/2/?documentUUID=7fb4b700-d447-4d47-9146-29caa7c11c75,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](C)(CCCN([Si](C)(C)C)[Si](C)(C)C)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/87060207,PubChem,CCO[Si](C)(CCCN([Si](C)(C)C)[Si](C)(C)C)OCC,Train,1,2702,training
-"EU_REACH:
-2,6-dichlorobenzyl chloride",,2014-83-7,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23571/7/4/2/?documentUUID=953a3de9-4417-45b2-830f-123688766ecb,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C(=C1)Cl)CCl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/74832,PubChem,ClCc1c(Cl)cccc1Cl,Train,1,2702,training
-"AU_HCIS:
-1-Tetradecanamine",,2016-42-4,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4988,,,AU_HCIS,1,CCCCCCCCCCCCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/16217,PubChem,CCCCCCCCCCCCCCN,Train,1,2702,training
-"EU_REACH:
-2-[(2-hexyldecyl)oxy]benzamide",,202483-62-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1243/7/4/2/?documentUUID=ede46184-ffc3-4a0e-b2ea-b1ad436c78d1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCC(CCCCCC)COC1=CC=CC=C1C(=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/18740353,PubChem,CCCCCCCCC(CCCCCC)COc1ccccc1C(N)=O,Train,1,2702,training
-"NZ_CCID:
-Bromoacetaldehyde diethyl acetal",,2032-35-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/991DC4DC-7700-481E-ACA0-BD6B9595BC50,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCOC(CBr)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/74852,PubChem,CCOC(CBr)OCC,Train,1,2702,training
-"EU_REACH:
-2-(4-methylpentan-2-yl)aniline",,203448-76-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16251/7/4/2/?documentUUID=e566909c-0c98-4068-892d-4613a4b76193,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CC(C)C1=CC=CC=C1N,https://pubchem.ncbi.nlm.nih.gov/compound/11528441,PubChem,CC(C)CC(C)c1ccccc1N,Train,1,2702,training
-"NZ_CCID:
-N-(2-Aminoethyl) morpholine",,2038-03-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/96F5C05E-8D55-4786-93A4-31CF2AB2BCEE,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1COCCN1CCN,https://pubchem.ncbi.nlm.nih.gov/compound/408285,PubChem,NCCN1CCOCC1,Train,1,2702,training
-"JP_CHRIP:
-o-chlorostyrene","JP_CHRIP:
-2-Chloroethenylbenzene
-2-Chlorostyrene",2039-87-4,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0687e.html,"JP_CHRIP:
-Based on descriptions regarding rabbit test of ""irritant"" (HSDB (2002)) and that ""the substance is irritating to the eyes and the skin"" (ICSC (2002)), it was classified as Category 2.",,JP_CHRIP,1,Clc1ccccc1C=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.139C,J-GLOBAL,C=Cc1ccccc1Cl,Train,1,2702,training
-"NZ_CCID:
-2-Bromostyrene",,2039-88-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/632A1D7A-3B58-46E7-AE80-32B9DE63DEBE,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C=CC1=CC=CC=C1Br,https://pubchem.ncbi.nlm.nih.gov/compound/16264,PubChem,C=Cc1ccccc1Br,Train,1,2702,training
-"EU_CLP:
-2-chloro-6-fluoro-phenol",,2040-90-6,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC(=C(C(=C1)Cl)O)F,https://pubchem.ncbi.nlm.nih.gov/compound/2773710,PubChem,Oc1c(F)cccc1Cl,Test,1,2702,training
-"EU_REACH:
-methyl 2-({4-[2-(2-chloro-6-cyano-4-nitrophenyl)diazen-1-yl]-5-acetamido-2-methoxyphenyl}(2-methoxy-2-oxoethyl)amino)propanoate",,204277-61-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/9885/7/4/2/?documentUUID=3c059641-8d9a-4749-98a3-92e171406676,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C(=O)OC)N(CC(=O)OC)C1=C(C=C(C(=C1)NC(=O)C)N=NC2=C(C=C(C=C2Cl)[N+](=O)[O-])C#N)OC,https://pubchem.ncbi.nlm.nih.gov/compound/73555313,PubChem,COC(=O)CN(c1cc(NC(C)=O)c(N=Nc2c(Cl)cc([N+](=O)[O-])cc2C#N)cc1OC)C(C)C(=O)OC,Train,1,2702,training
-"EU_REACH:
-(Z)-N-[2-(2-hydroxyethoxy)ethyl]-9-octadecenamide",,20429-33-8,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24110/7/4/2/?documentUUID=fdfe325d-0855-439e-8f8c-ef177b069e2f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCC/C=C\CCCCCCCC(=O)NCCOCCO,https://pubchem.ncbi.nlm.nih.gov/compound/6436522,PubChem,CCCCCCCC/C=C\CCCCCCCC(=O)NCCOCCO,Train,1,2702,training
-"AU_HCIS:
-9-Octadecenamide, N-[3-(dimethylamino)propyl]-12-hydroxy-, [R-(Z)]-",,20457-75-4,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6763,,,AU_HCIS,1,CCCCCC[C@H](C/C=C\CCCCCCCC(=O)NCCCN(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/6436523,PubChem,CCCCCC[C@@H](O)C/C=C\CCCCCCCC(=O)NCCCN(C)C,Train,1,2702,training
-"EU_REACH:
-2-[4,6-bis({[1,1'-biphenyl]-4-yl})-1,3,5-triazin-2-yl]-5-[(2-ethylhexyl)oxy]phenol",,204583-39-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12741/7/4/2/?documentUUID=5f40fee0-25ac-46a1-8a30-3750d0fc4e48,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC1=CC(=C(C=C1)C2=NC(=NC(=N2)C3=CC=C(C=C3)C4=CC=CC=C4)C5=CC=C(C=C5)C6=CC=CC=C6)O,https://pubchem.ncbi.nlm.nih.gov/compound/135415896,PubChem,CCCCC(CC)COc1ccc(-c2nc(-c3ccc(-c4ccccc4)cc3)nc(-c3ccc(-c4ccccc4)cc3)n2)c(O)c1,Train,1,2702,training
-"EU_REACH:
-prop-2-en-1-yl 2-(2-chloro-5-isocyanatobenzoyloxy)-2-methylpropanoate",,204918-22-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8166/7/4/2/?documentUUID=1dc69cbc-5fb5-4ed7-b653-f61127343230,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C(=O)OCC=C)OC(=O)C1=C(C=CC(=C1)N=C=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10936216,PubChem,C=CCOC(=O)C(C)(C)OC(=O)c1cc(N=C=O)ccc1Cl,Test,1,2702,training
-"NZ_CCID:
-Amyl salicylate","NZ_CCID:
-Benzoic acid, 2-hydroxy-, pentyl ester, Salicylic acid, pentyl ester",2050-08-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7976ED49-065B-4DEE-A104-9B0FE45428A6,"NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Severe
-REFERENCE SOURCE: CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- Volume(issue)/page/year: 94(8),41,1979. [HAZARD.COM]",,NZ_CCID,1,CCCCCOC(=O)C1=CC=CC=C1O,https://pubchem.ncbi.nlm.nih.gov/compound/16299,PubChem,CCCCCOC(=O)c1ccccc1O,Train,1,2702,training
-"AU_HCIS:
-Ethanedioic acid, dibutyl ester",,2050-60-4,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5155,,,AU_HCIS,1,CCCCOC(=O)C(=O)OCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/16306,PubChem,CCCCOC(=O)C(=O)OCCCC,Train,1,2702,training
-"NZ_CCID:
-1-Pentanamine, N-pentyl-","NZ_CCID:
-Di-n-amylamine, Diamylamine",2050-92-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/463B9978-CC9A-4F54-9E97-52E09F9DEA49,"NZ_CCID:
-Skin Irritation
-SPECIES:
-RESULT: Causes severe eye and skin burns.
-REFERENCE SOURCE: National Fire Protection Guide. Fire Protection Guide on Hazardous Materials. 10 th ed. Quincy, MA: National Fire Protection Association, 1991.,p. 49-62. **PEER REVIEWED**
-[HSDB]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Severe burn.
-REFERENCE SOURCE: Snyder, R. (ed.). Ethyl Brownings Toxicity and Metabolism of Industrial Solvents. 2nd ed. Volume II: Nitrogen and Phosphorus Solvents. Amsterdam-New York-Oxford: Elsevier, 1990. 40. **PEER REVIEWED**
-[HSDB]",,NZ_CCID,1,CCCCCNCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/16316,PubChem,CCCCCNCCCCC,Train,1,2702,training
-"NZ_CCID:
-Hexanoic anhydride",,2051-49-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/15E8EB32-B7E0-44C1-93BA-1F7D29250375,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCC(=O)OC(=O)CCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/74918,PubChem,CCCCCC(=O)OC(=O)CCCCC,Train,1,2702,training
-"NZ_CCID:
-Dichlorodiphenylmethane",,2051-90-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E4347012-FB60-487B-84A6-A0EE895F0FD0,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)C(C2=CC=CC=C2)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/16327,PubChem,ClC(Cl)(c1ccccc1)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-3-Benzoylpropionic acid",,2051-95-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/31A5F82E-1368-47B0-9555-A7FC765A9F6B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)C(=O)CCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/72871,PubChem,O=C(O)CCC(=O)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-5-Bromovaleric acid",,2067-33-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6CF4BFD3-E137-4F0E-AF11-C729829E613B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(CCBr)CC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/16368,PubChem,O=C(O)CCCCBr,Train,1,2702,training
-"NZ_CCID:
-1,8-Bis(dimethylamino)-naphthalene",,20734-58-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3242C7F8-AFC8-4DCF-BE8C-CE3655358788,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CN(C)C1=CC=CC2=C1C(=CC=C2)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/88675,PubChem,CN(C)c1cccc2cccc(N(C)C)c12,Train,1,2702,training
-"EU_REACH:
-2-bromo-2-methylpropanoyl bromide",,20769-85-1,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13206/7/4/2/?documentUUID=50df84dd-6c27-484a-9eab-8ba4aeeb87f4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C(=O)Br)Br,https://pubchem.ncbi.nlm.nih.gov/compound/88685,PubChem,CC(C)(Br)C(=O)Br,Test,1,2702,training
-"AU_HCIS:
-Heptanenitrile, 2-propyl-",,208041-98-9,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=2353,,,AU_HCIS,1,CCCCCC(CCC)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/22376131,PubChem,CCCCCC(C#N)CCC,Train,1,2702,training
-"NZ_CCID:
-Pentanoic anhydride","NZ_CCID:
-valeric anhydride",2082-59-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8F8B45F8-B32D-4531-A315-7BE8AB9388CD,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCC(=O)OC(=O)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/74959,PubChem,CCCCC(=O)OC(=O)CCCC,Train,1,2702,training
-"JP_CHRIP:
-n-Octadecyl 3-(4'-hydroxy-3',5'-di-t-butylphenyl) propionate","JP_CHRIP:
-n-octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl) propionate
-n-octadecyl ester 3-(4'-hydroxy-3',5'-di-tert-butylphenyl)propionate
-Octadecyl 3,5-di-tert-butyl-4-hydroxyhydrocinnamate; Octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate
-octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate",2082-79-3,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0030e.html,"JP_CHRIP:
-It is described that in a skin irritation study (OECD TG 404) using rabbits exposed to an undiluted solution of this substance for 24 hours, no irritation was observed (SIDS (2006)). Therefore, this substance was classified as ""Not classified"" based on the description that this substance is not regarded as a skin irritant (SIDS (2006)).",Provided,JP_CHRIP,1,CCCCCCCCCCCCCCCCCCOC(=O)CCc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J21.231H,J-GLOBAL,CCCCCCCCCCCCCCCCCCOC(=O)CCc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1,Train,1,2702,training
-"NZ_CCID:
-2-Propenoic acid, 2-methyl-, 1,4-butanediyl ester","NZ_CCID:
-1,4-Butanediol dimethacrylate, 1,4-Butylene dimethacrylate, 1,4-Butylene glycol dimethacrylate, Butanediol dimethacrylate, Butylene dimethacrylate, Methacrylic acid, tetramethylene ester, Oligotetramethylene glycol dimethacrylate, Tetramethylene dimethacrylate Tetramethylene glycol dimethacrylate Tetramethylene dimethacrylate, Tetramethylene glycol dimethacrylate, Tetramethylene methacrylate, X 970",2082-81-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/41E5D5D6-9426-44E6-9611-1A382C896AF5,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,CC(=C)C(=O)OCCCCOC(=O)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/16387,PubChem,C=C(C)C(=O)OCCCCOC(=O)C(=C)C,Train,1,2702,training
-"EU_REACH:
-5-butoxy-2-[4-(4-butoxy-2-hydroxyphenyl)-6-(2,4-dibutoxyphenyl)-1,3,5-triazin-2-yl]phenol",,208343-47-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30662/7/4/2/?documentUUID=ca06e6d9-03f0-4bed-b7f5-2997854dc2c3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOC1=CC(=C(C=C1)C2=NC(=NC(=N2)C3=C(C=C(C=C3)OCCCC)OCCCC)C4=C(C=C(C=C4)OCCCC)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/135431040,PubChem,CCCCOc1ccc(-c2nc(-c3ccc(OCCCC)cc3O)nc(-c3ccc(OCCCC)cc3OCCCC)n2)c(O)c1,Train,1,2702,training
-"NZ_CCID:
-Dimethylaminotrimethylsilane","NZ_CCID:
-N,N-dimethyltrimethylsilylamine",2083-91-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6D42137E-6E23-4DFE-925C-BC45A5779053,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CN(C)[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/74965,PubChem,CN(C)[Si](C)(C)C,Train,1,2702,training
-"EU_REACH:
-1-butoxy-2,3-difluoro-4-[(1s,4r)-4-propylcyclohexyl]benzene",,208709-55-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21891/7/4/2/?documentUUID=b0549549-1480-44a3-b99f-b578b7f3441b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOC1=C(C(=C(C=C1)C2CCC(CC2)CCC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/22184028,PubChem,CCCCOc1ccc(C2CCC(CCC)CC2)c(F)c1F,Train,1,2702,training
-"KR_NCIS:
-2-Thienylacetonitrile",,20893-30-5,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C1=CSC(=C1)CC#N,https://pubchem.ncbi.nlm.nih.gov/compound/72880,PubChem,N#CCc1cccs1,Train,1,2702,training
-"US_HSDB:
-ACENAPHTHYLENE",,208-96-8,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/2661,,,US_HSDB,1,C1=CC2=C3C(=C1)C=CC3=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/9161,PubChem,C1=Cc2cccc3cccc1c23,Train,1,2702,training
-"KR_NCIS:
-3-[(Prop-1-en-2-yl)phenyl]prop-2-yl isocyanate","KR_NCIS:
-1-(1-Isocyanato-1-methylethyl)-3-isopropenylbenzene; 2-(3-(Prop-1-en-2-yl)phenyl)prop-2-yl isocyanate; 3-[(Prop-1-en-2-yl)phenyl]prop-2-yl isocyanate; 3-Isopropenyl-a,a-dimethylbenzyl isocyanate; 3-Isopropenyl-a,a'-dimethylbenzyl isocyanate; a,a-Dimethyl-m-isopropenylbenzyl isocyanate; Benzene, 1-(1-isocyanato-1-methylethyl)-3-(1-methylethenyl)-; Isocyanic acid, m-isopropenyl-a,a-dimethylbenzyl ester; m-Isopropenyl-a,a-dimethylbenzyl isocyanate; m-Isopropenylcumyl isocyanate",2094-99-7,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CC(=C)C1=CC(=CC=C1)C(C)(C)N=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/604152,PubChem,C=C(C)c1cccc(C(C)(C)N=C=O)c1,Train,1,2702,training
-"EU_REACH:
-N,N-bis[(oxiran-2-yl)methyl]aniline",,2095-06-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26718/7/4/2/?documentUUID=9579e671-848f-4614-9ed1-1bf4ac575439,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C(O1)CN(CC2CO2)C3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/16412,PubChem,c1ccc(N(CC2CO2)CC2CO2)cc1,Test,1,2702,training
-"NZ_CCID:
-7-Bromoheptanonitrile","NZ_CCID:
-7-bromoheptanenitrile",20965-27-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/52D688AB-6134-4905-ADA4-4E123BA36050,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(CCCBr)CCC#N,https://pubchem.ncbi.nlm.nih.gov/compound/88737,PubChem,N#CCCCCCCBr,Train,1,2702,training
-"ChemSkin:
-Capryl-isostearate",,209802-43-7,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,CCCCCCC(C)OC(=O)CCCCCCCCCCCCCCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/86200975,PubChem,CCCCCCC(C)OC(=O)CCCCCCCCCCCCCCC(C)C,Test,1,2702,training
-"EU_REACH:
-2-(2,4,5-trifluorophenyl)acetic acid",,209995-38-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33530/7/4/2/?documentUUID=2dd0c89a-0dcd-449a-af8e-3849f26e6852,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(C(=CC(=C1F)F)F)CC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/2777950,PubChem,O=C(O)Cc1cc(F)c(F)cc1F,Train,1,2702,training
-"JP_CHRIP:
-(E)-1-(2-Chloro-1,3-thiazol-5-ylmethyl)-3-methyl-2-nitroguanidine; Clothianidin",,210880-92-5,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0027e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified as ""Not classified"" from (1).
-
-[Evidence Data]
-(1) It is reported that in a skin irritation test with rabbits (n = 6) (OECD TG 404, GLP, 4-hour application, 72-hour observation), no skin irritation was seen (erythema/eschar score: 0/0/0/0/0/0, edema score: 0/0/0/0/0/0) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014), JMPR (2010), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2015)).",Provided,JP_CHRIP,1,CNC(=N[N+](=O)[O-])NCc1cnc(Cl)s1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.082.227K,J-GLOBAL,CNC(=N[N+](=O)[O-])NCc1cnc(Cl)s1,Train,1,2702,training
-"EU_REACH:
-3-(triethoxysilyl)propyl 2-methylprop-2-enoate",,21142-29-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25613/7/4/2/?documentUUID=ce14ffe0-9dfa-4556-94b1-8a7a4cb14b79,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](CCCOC(=O)C(=C)C)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/88798,PubChem,C=C(C)C(=O)OCCC[Si](OCC)(OCC)OCC,Train,1,2702,training
-"NZ_CCID:
-4-Benzylpyridine",,2116-65-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/41797F25-FA7F-4870-BE3F-9939D3344791,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)CC2=CC=NC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/16458,PubChem,c1ccc(Cc2ccncc2)cc1,Train,1,2702,training
-"EU_REACH:
-1,1,5,5,5-hexamethyl-3-phenyl-3-[(trimethylsilyl)oxy]trisiloxane",,2116-84-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22255/7/4/2/?documentUUID=6462f52c-eb1e-4672-ba6c-225bf2d324d1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](C)(C)O[Si](C1=CC=CC=C1)(O[Si](C)(C)C)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/62427,PubChem,C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)c1ccccc1,Train,1,2702,training
-"EU_REACH:
-2-hydroxy-N-((2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl)octadecanamide",,212070-45-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30008/7/4/2/?documentUUID=802f2d95-c389-4f91-8842-8f72c9e3434c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCC(C(=O)N[C@@H](CO)[C@@H]([C@@H](CCCCCCCCCCCCCC)O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/44625889,PubChem,CCCCCCCCCCCCCCCCC(O)C(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC,Train,1,2702,training
-"NZ_CCID:
-Butanoic acid, 3-oxo-, 2-[(2-methyl-1-oxo-2-propenyl)oxy]ethyl ester",,21282-97-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/369A91E5-46BB-4566-8127-ADF111F90CB9,,,NZ_CCID,1,CC(=C)C(=O)OCCOC(=O)CC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/88855,PubChem,C=C(C)C(=O)OCCOC(=O)CC(C)=O,Train,1,2702,training
-"EU_REACH:
-4-(naphthalen-2-yl)-1,3-thiazol-2-amine",,21331-43-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26580/7/4/2/?documentUUID=3f2eeeb8-d51b-4cca-9f29-a99125d90f6e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C=C(C=CC2=C1)C3=CSC(=N3)N,https://pubchem.ncbi.nlm.nih.gov/compound/673702,PubChem,Nc1nc(-c2ccc3ccccc3c2)cs1,Train,1,2702,training
-"EU_REACH:
-1-chloro-2-(trichloromethyl)benzene",,2136-89-2,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5219/7/4/2/?documentUUID=b92262fd-b866-4641-b785-8fbdf8a2f1b1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=C1)C(Cl)(Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/16494,PubChem,Clc1ccccc1C(Cl)(Cl)Cl,Train,1,2702,training
-"NZ_CCID:
-3'-Bromoacetophenone",,2142-63-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/04B1F61C-2F94-4BC4-BA42-1AF360777C3C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(=O)C1=CC(=CC=C1)Br,https://pubchem.ncbi.nlm.nih.gov/compound/16502,PubChem,CC(=O)c1cccc(Br)c1,Train,1,2702,training
-"EU_REACH:
-3-hydroxy-N'-(4-methylpentan-2-ylidene)naphthalene-2-carbohydrazide",,214417-91-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32159/7/4/2/?documentUUID=9317eef4-7dad-426e-998e-5f7eba95c8fe,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C/C(=N\NC(=O)C1=CC2=CC=CC=C2C=C1O)/C,https://pubchem.ncbi.nlm.nih.gov/compound/5779530,PubChem,C/C(CC(C)C)=N/NC(=O)c1cc2ccccc2cc1O,Train,1,2702,training
-"EU_REACH:
-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl 2-methylprop-2-enoate",,2144-53-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14308/7/4/2/?documentUUID=7de41c5c-9f3a-4ddc-9fc8-1f3261ed91b3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OCCC(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/75066,PubChem,C=C(C)C(=O)OCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Test,1,2702,training
-"EU_REACH:
-ethenyl dodecanoate",,2146-71-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1546/7/4/2/?documentUUID=b089207e-b8eb-4e3c-8384-f20e20d0feda,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCC(=O)OC=C,https://pubchem.ncbi.nlm.nih.gov/compound/75069,PubChem,C=COC(=O)CCCCCCCCCCC,Train,1,2702,training
-"AU_HCIS:
-1-Docosanamine, N,N-dimethyl-",,21542-96-1,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5007,,,AU_HCIS,1,CCCCCCCCCCCCCCCCCCCCCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/88942,PubChem,CCCCCCCCCCCCCCCCCCCCCCN(C)C,Train,1,2702,training
-"EU_REACH:
-dodecyl prop-2-enoate",,2156-97-0,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15805/7/4/2/?documentUUID=14bd7fe1-9e48-4f77-8c44-2e13b46e93ac,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCOC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/75084,PubChem,C=CC(=O)OCCCCCCCCCCCC,Train,1,2702,training
-"NZ_CCID:
-t-Butyldiethanolamine",,2160-93-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/947540D4-3595-4257-A95E-4868D4EED875,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 34. [Chemwatch]
-Eye Irritation
-R-PHRASE: R 34/ 41. [Chemwatch]",,NZ_CCID,1,CC(C)(C)N(CCO)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/62430,PubChem,CC(C)(C)N(CCO)CCO,Train,1,2702,training
-"NZ_CCID:
-2-Methoxybenzoyl chloride","NZ_CCID:
-o-anisoyl chloride",21615-34-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EE70EB9C-E609-4510-8733-1EC1A3FED432,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,COC1=CC=CC=C1C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/88969,PubChem,COc1ccccc1C(=O)Cl,Train,1,2702,training
-"EU_REACH:
-2,4-diisocyanato-1,3,5-tris(propan-2-yl)benzene",,2162-73-4,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10639/7/4/2/?documentUUID=9556e450-f07b-4c4d-b9ae-64cd35cd9ead,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1=CC(=C(C(=C1N=C=O)C(C)C)N=C=O)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/75099,PubChem,CC(C)c1cc(C(C)C)c(N=C=O)c(C(C)C)c1N=C=O,Train,1,2702,training
-"EU_REACH:
-N,N'-bis[2,6-bis(propan-2-yl)phenyl]methanediimine",,2162-74-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13695/7/4/2/?documentUUID=2c9cfe0f-29cb-4ba3-a9f4-f6b07cde159c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1=C(C(=CC=C1)C(C)C)N=C=NC2=C(C=CC=C2C(C)C)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/75100,PubChem,CC(C)c1cccc(C(C)C)c1N=C=Nc1c(C(C)C)cccc1C(C)C,Train,1,2702,training
-"NZ_CCID:
-1,10-Dichlorodecane",,2162-98-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2EFCC033-F1D0-464B-880F-09E2457B65FF,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C(CCCCCCl)CCCCCl,https://pubchem.ncbi.nlm.nih.gov/compound/75101,PubChem,ClCCCCCCCCCCCl,Train,1,2702,training
-"NZ_CCID:
-1,8-Dichlorooctane",,2162-99-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D59B1FA3-6658-44E7-83C1-3757FB513954,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C(CCCCCl)CCCCl,https://pubchem.ncbi.nlm.nih.gov/compound/75102,PubChem,ClCCCCCCCCCl,Train,1,2702,training
-"EU_REACH:
-tetradecyl prop-2-enoate",,21643-42-5,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5562/7/4/2/?documentUUID=18c7ce76-11da-4d07-881b-968162f0f0b3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCOC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/88984,PubChem,C=CC(=O)OCCCCCCCCCCCCCC,Train,1,2702,training
-"EU_REACH:
-2-[2-oxo-5-(2,4,4-trimethylpentan-2-yl)-2,3-dihydro-1-benzofuran-3-yl]-4-(2,4,4-trimethylpentan-2-yl)phenyl acetate",,216698-07-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6619/7/4/2/?documentUUID=c6d774d3-0dfa-451d-a287-ce84e39797cd,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)OC1=C(C=C(C=C1)C(C)(C)CC(C)(C)C)C2C3=C(C=CC(=C3)C(C)(C)CC(C)(C)C)OC2=O,https://pubchem.ncbi.nlm.nih.gov/compound/154218,PubChem,CC(=O)Oc1ccc(C(C)(C)CC(C)(C)C)cc1C1C(=O)Oc2ccc(C(C)(C)CC(C)(C)C)cc21,Train,1,2702,training
-"EU_REACH:
-2,2-bis(tert-butylperoxy)butane",,2167-23-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22574/7/4/2/?documentUUID=40188a88-67cc-44b6-9147-0b45cb8da0ca,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)(OOC(C)(C)C)OOC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/221260,PubChem,CCC(C)(OOC(C)(C)C)OOC(C)(C)C,Train,1,2702,training
-"EU_REACH:
-phenyl 2-methylprop-2-enoate",,2177-70-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17121/7/4/2/?documentUUID=b7a9a25a-72a8-422c-ae93-67f0ffaf9797,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/75121,PubChem,C=C(C)C(=O)Oc1ccccc1,Train,1,2702,training
-"EU_REACH:
-3-((C9-11-iso,C10-rich)alkyloxy)propan-1-amine",,218141-16-3,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12430/7/4/2/?documentUUID=4e6088ca-b703-4181-85fc-a9c3249544a8,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCCCOCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/120013,PubChem,CC(C)CCCCCCCOCCCN,Train,1,2702,training
-"EU_REACH:
-1,1'-propane-2,2-diylbis[3,5-dibromo-4-(2,3-dibromopropoxy)benzene]",,21850-44-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13876/7/4/2/?documentUUID=fac33602-52dc-4686-8415-d3f9989ff39e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C1=CC(=C(C(=C1)Br)OCC(CBr)Br)Br)C2=CC(=C(C(=C2)Br)OCC(CBr)Br)Br,https://pubchem.ncbi.nlm.nih.gov/compound/62753,PubChem,CC(C)(c1cc(Br)c(OCC(Br)CBr)c(Br)c1)c1cc(Br)c(OCC(Br)CBr)c(Br)c1,Train,1,2702,training
-"EU_REACH:
-(1r,4r)-4-tert-butylcyclohexan-1-ol",,21862-63-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10189/7/4/2/?documentUUID=f1d78275-c1aa-4689-b69d-9ee223eee158,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1CCC(CC1)O,https://pubchem.ncbi.nlm.nih.gov/compound/7391,PubChem,CC(C)(C)C1CCC(O)CC1,Train,1,2702,training
-"EU_REACH:
-1,1,1,3,3-pentachlorobutane",,21981-33-9,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10191/7/4/2/?documentUUID=1c7dc680-2a62-4bb6-a3db-f32e583d50d3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CC(Cl)(Cl)Cl)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/89123,PubChem,CC(Cl)(Cl)CC(Cl)(Cl)Cl,Test,1,2702,training
-"NZ_CCID:
-6-Amino-1,4-benzodioxane","NZ_CCID:
-1,4-benzodioxan-6-amine",22013-33-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6719F483-3093-45DB-9287-D539CB3C166C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C1COC2=C(O1)C=CC(=C2)N,https://pubchem.ncbi.nlm.nih.gov/compound/89148,PubChem,Nc1ccc2c(c1)OCCO2,Train,1,2702,training
-"NZ_CCID:
-Ketoprofen","NZ_CCID:
-Benzeneacetic acid, 3-benzoyl-alpha-methyl-, Propionic acid, 2-(3-benzoylphenyl)-",22071-15-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F8A3137F-8DAA-418C-9393-5F9AF19A6618,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38
-[http://www.chemicalland21.com/arokorhi/lifescience/phar/KETOPROFEN.htm]
-Eye Irritation
-R PHRASE: R 36
-[http://www.chemicalland21.com/arokorhi/lifescience/phar/KETOPROFEN.htm]",,NZ_CCID,1,CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/3825,PubChem,CC(C(=O)O)c1cccc(C(=O)c2ccccc2)c1,Train,1,2702,training
-"EU_REACH:
-1-{[3-(triethoxysilyl)propyl]sulfanyl}octan-1-one",,220727-26-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17060/7/4/2/?documentUUID=3dbbb484-738b-45d5-89c0-d369e762126c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCC(=O)SCCC[Si](OCC)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/12135713,PubChem,CCCCCCCC(=O)SCCC[Si](OCC)(OCC)OCC,Train,1,2702,training
-"AU_HCIS:
-Oxirane, pentadecyl-",,22092-38-2,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5461,,,AU_HCIS,1,CCCCCCCCCCCCCCCC1CO1,https://pubchem.ncbi.nlm.nih.gov/compound/89596,PubChem,CCCCCCCCCCCCCCCC1CO1,Train,1,2702,training
-"EU_CLP:
-5-endo-hexyl-bicyclo[2.2.1]hept-2-ene",,22094-83-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCCCCCC1CC2CC1C=C2,https://pubchem.ncbi.nlm.nih.gov/compound/21584940,PubChem,CCCCCCC1CC2C=CC1C2,Test,1,2702,training
-"EU_REACH:
-2,2'-[(2,2',5,5'-tetrachlorobiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis[N-(2,4-dimethylphenyl)-3-oxobutanamide]",,22094-93-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2023/7/4/2/?documentUUID=5bcaa16e-70fa-4f9a-99bb-4c89e7486457,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)NC(=O)C(C(=O)C)N=NC2=C(C=C(C(=C2)Cl)C3=CC(=C(C=C3Cl)N=NC(C(=O)C)C(=O)NC4=C(C=C(C=C4)C)C)Cl)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/89597,PubChem,CC(=O)C(N=Nc1cc(Cl)c(-c2cc(Cl)c(N=NC(C(C)=O)C(=O)Nc3ccc(C)cc3C)cc2Cl)cc1Cl)C(=O)Nc1ccc(C)cc1C,Train,1,2702,training
-"EU_REACH:
-oxirane",,2210-79-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14553/7/4/2/?documentUUID=cc9d19cc-c0a6-421c-a7e4-ade45e36dbdc,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=CC=C1OCC2CO2,https://pubchem.ncbi.nlm.nih.gov/compound/16640,PubChem,Cc1ccccc1OCC1CO1,Train,1,2702,training
-"NZ_CCID:
-2-(Bromomethyl)-benzonitrile",,22115-41-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E43BBD58-9746-430F-980E-8C24A96EC1AC,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)CBr)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/89599,PubChem,N#Cc1ccccc1CBr,Train,1,2702,training
-"EU_REACH:
-(2-chloro-1,1-diethoxyethyl)silane",,2212-10-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/28089/7/4/2/?documentUUID=630601cb-2d5c-4495-80f0-43579cf0e1e6,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](C)(CCl)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/16650,PubChem,CCO[Si](C)(CCl)OCC,Train,1,2702,training
-"JP_CHRIP:
-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexan-1-ol","JP_CHRIP:
-L-menthol",2216-51-5,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-0090e.html,"JP_CHRIP:
-It was classified in Category 2 because it is reported that the average scores for erythema and edema were 3.0, 2.9, respectively in a test in which undiluted this substance was applied to rabbits (according to OECD TG 404), and recovery was seen 14 days after application (SIDS (2004)).",Provided,JP_CHRIP,1,CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J9.251G,J-GLOBAL,CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O,Train,1,2702,training
-"EU_REACH:
-N-cyclopropyl-4-[(2-methoxybenzoyl)sulfamoyl]benzamide",,221667-31-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1169/7/4/2/?documentUUID=ea104b4d-7687-412c-b07c-025ce5a29854,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC=CC=C1C(=O)NS(=O)(=O)C2=CC=C(C=C2)C(=O)NC3CC3,https://pubchem.ncbi.nlm.nih.gov/compound/11707647,PubChem,COc1ccccc1C(=O)NS(=O)(=O)c1ccc(C(=O)NC2CC2)cc1,Train,1,2702,training
-"EU_REACH:
-3,3'-[methylenebis(oxymethylene)]diheptane",,22174-70-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11718/7/4/2/?documentUUID=f0974541-11af-40a6-9077-7ddca1adcfd1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COCOCC(CC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/89612,PubChem,CCCCC(CC)COCOCC(CC)CCCC,Train,1,2702,training
-"EU_REACH:
-endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate",,22235-81-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6852/7/4/2/?documentUUID=ed80495f-2664-4875-a566-f8553080019b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)N1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/20625249,PubChem,CC(C)N1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2,Train,1,2702,training
-"NZ_CCID:
-Neopentylglycol diacrylate","NZ_CCID:
-2-Propenoic acid, 2,2-dimethyl-1,3-propanediyl ester",2223-82-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/32E45EF4-7B5C-4B50-B2BD-0E1D3413A769,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]
-Eye Irritation
-R PHRASE: R 36 [ECB]",,NZ_CCID,1,CC(C)(COC(=O)C=C)COC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/16680,PubChem,C=CC(=O)OCC(C)(C)COC(=O)C=C,Train,1,2702,training
-"EU_CLP:
-1,1,3,3-tetramethylbutylperoxypivalate",,22288-41-1,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C)(C)CC(C)(C)OOC(=O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/53446567,PubChem,CC(C)(C)CC(C)(C)OOC(=O)C(C)(C)C,Test,1,2702,training
-"EU_REACH:
-1-(2,4-dichlorophenyl)ethan-1-one",,2234-16-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5283/7/4/2/?documentUUID=44e36bc1-55ee-418c-bf87-51f763d5efe4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C1=C(C=C(C=C1)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/16693,PubChem,CC(=O)c1ccc(Cl)cc1Cl,Train,1,2702,training
-"JP_CHRIP:
-2,2'-[oxybis(methylene)]bisoxirane","JP_CHRIP:
-2,2'-(Oxybis(methylene))bis-oxirane
-Bis(2,3-epoxypropyl) ether
-bis(2,3-Epoxypropyl)ether
-DGE
-Diglycidyl ether
-Oxirane, 2,2'-[oxybis(methylene)]bis-",2238-07-5,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0889e.html,"JP_CHRIP:
-It was set as Category 2 from descriptions that severe irritation which produced erythema, edema and eschar was acknowledged in the test using the rabbit (ACGIH (7th, 2001)), and that severe irritation and chemical burn were acknowledged when single time application was done in the rabbit skin (PATTY (4th, 1994)).",,JP_CHRIP,1,C(OCC1CO1)C1CO1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J53.970H,J-GLOBAL,C(OCC1CO1)C1CO1,Train,1,2702,training
-"JP_CHRIP:
-1,5-Diaminonaphthalene","JP_CHRIP:
-1,5-Diaminonaphthalene
-1,5-Naphthalenediamine
-1,5-Naphthylenediamine",2243-62-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0162e.html,"JP_CHRIP:
-On the basis that a semi-occlusive test (OECD TG 404) applied 500 mg test substance to rabbit skin for 4 hours resulted in irritation scores of 0 in all animals at all observation points and no primary irritant effects (BUA Report 115 (1995)), it was classified as ""Not classified.""",Provided,JP_CHRIP,1,Nc1cccc2c(N)cccc12,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J40.472A,J-GLOBAL,Nc1cccc2c(N)cccc12,Train,1,2702,training
-"NZ_CCID:
-2-Naphthoyl chloride",,2243-83-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/92F6303F-FC38-4399-BEBA-B45E831F2309,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C2C=C(C=CC2=C1)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/75246,PubChem,O=C(Cl)c1ccc2ccccc2c1,Train,1,2702,training
-"EU_REACH:
-4-(butan-2-yloxy)-3,5-dimethoxybenzaldehyde",,224586-49-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30811/7/4/2/?documentUUID=79976e59-e65a-445d-a3b6-a191f86a5c5a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)OC1=C(C=C(C=C1OC)C=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/23110023,PubChem,CCC(C)Oc1c(OC)cc(C=O)cc1OC,Train,1,2702,training
-"EU_REACH:
-ethyl trans-2,2,6-trimethylcyclohexanecarboxylate",,22471-55-2,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19578/7/4/2/?documentUUID=96d92425-81f1-40c9-9771-41ad62d133ad,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)[C@@H]1[C@H](CCCC1(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11735763,PubChem,CCOC(=O)[C@@H]1[C@@H](C)CCCC1(C)C,Train,1,2702,training
-"EU_REACH:
-2-{2-ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one",,224785-90-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6882/7/4/2/?documentUUID=dea19b55-a44c-4782-a77d-f928d26b2131,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1=NC(=C2N1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC)C,https://pubchem.ncbi.nlm.nih.gov/compound/135400189,PubChem,CCCc1nc(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)nn12,Train,1,2702,training
-"NZ_CCID:
-Aminoacetaldehyde dimethyl acetal",,22483-09-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FDFDB25E-8821-4188-946E-9D277017000D,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,COC(CN)OC,https://pubchem.ncbi.nlm.nih.gov/compound/89728,PubChem,COC(CN)OC,Train,1,2702,training
-"EU_REACH:
-2-[(3-sulfanylpropanoyl)oxy]ethyl 3-sulfanylpropanoate",,22504-50-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26261/7/4/2/?documentUUID=efb35323-721e-429f-8666-1fcdb9bb9aff,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CS)C(=O)OCCOC(=O)CCS,https://pubchem.ncbi.nlm.nih.gov/compound/89735,PubChem,O=C(CCS)OCCOC(=O)CCS,Train,1,2702,training
-"EU_REACH:
-6-chloro-1,3-benzoxazole",,227197-72-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11364/7/4/2/?documentUUID=971c7857-cfdf-4d77-a677-abec60100a85,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=C(C=C1Cl)OC=N2,https://pubchem.ncbi.nlm.nih.gov/compound/9350362,PubChem,Clc1ccc2ncoc2c1,Train,1,2702,training
-"NZ_CCID:
-6-Bromohexanoyl chloride","NZ_CCID:
-6-bromocaproyl chloride",22809-37-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/49143CBD-78C4-495B-A00F-443A4A04A367,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(CCC(=O)Cl)CCBr,https://pubchem.ncbi.nlm.nih.gov/compound/89848,PubChem,O=C(Cl)CCCCCBr,Train,1,2702,training
-"NZ_CCID:
-Hexaethyltriaminophosphine",,2283-11-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/480DD3BC-06BD-49D2-99C6-829D1F8C1891,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCN(CC)P(N(CC)CC)N(CC)CC,https://pubchem.ncbi.nlm.nih.gov/compound/75292,PubChem,CCN(CC)P(N(CC)CC)N(CC)CC,Train,1,2702,training
-"EU_REACH:
-propan-2-yl 2-(N-methyldodecanamido)acetate",,230309-38-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27893/7/4/2/?documentUUID=ab2f80da-094a-404c-b090-3364127aa324,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCC(=O)N(C)CC(=O)OC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/9926846,PubChem,CCCCCCCCCCCC(=O)N(C)CC(=O)OC(C)C,Train,1,2702,training
-"EU_CLP:
-benzyl 2,4-dibromobutanoate",,23085-60-1,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC=C(C=C1)COC(=O)C(CCBr)Br,https://pubchem.ncbi.nlm.nih.gov/compound/4338264,PubChem,O=C(OCc1ccccc1)C(Br)CCBr,Test,1,2702,training
-"EU_REACH:
-6-methyl-2-(4-methylcyclohex-3-en-1-yl)hept-5-en-2-ol",,23089-26-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23596/7/4/2/?documentUUID=eed7fe6e-d390-4569-8b9c-93190b918921,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC[C@H](CC1)[C@](C)(CCC=C(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/442343,PubChem,CC(C)=CCC[C@](C)(O)[C@@H]1CC=C(C)CC1,Train,1,2702,training
-"NZ_CCID:
-Propyl benzoate",,2315-68-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B3E39DFD-C858-443C-A943-18C8AFBF0EC4,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCCOC(=O)C1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/16846,PubChem,CCCOC(=O)c1ccccc1,Train,1,2702,training
-"EU_REACH:
-2-ethyl-2-{[2-ethyl-3-hydroxy-2-(hydroxymethyl)propoxy]methyl}propane-1,3-diol",,23235-61-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1913/7/4/2/?documentUUID=824a0efc-a53e-46d3-b7db-2e7cdf656a49,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(CO)(CO)COCC(CC)(CO)CO,https://pubchem.ncbi.nlm.nih.gov/compound/90038,PubChem,CCC(CO)(CO)COCC(CC)(CO)CO,Train,1,2702,training
-"EU_REACH:
-2-[2-(carboxymethoxy)ethoxy]acetic acid",,23243-68-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22578/7/4/2/?documentUUID=b0278698-75d7-4f15-81c6-a39c3805aa47,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(COCC(=O)O)OCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/90039,PubChem,O=C(O)COCCOCC(=O)O,Train,1,2702,training
-"NZ_CCID:
-6-Chloro-3,4-methylenedioxybenzyl chloride","NZ_CCID:
-6-chloropiperonyl chloride",23468-31-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/714839FB-64AA-4BA5-8CE6-3F322629C556,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1OC2=C(O1)C=C(C(=C2)CCl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/90113,PubChem,ClCc1cc2c(cc1Cl)OCO2,Train,1,2702,training
-"EU_REACH:
-3,3'-[(9,10-dioxo-9,10-dihydroanthracene-1,4-diyl)diimino]bis(N-cyclohexyl-2,4,6-trimethylbenzenesulfonamide)",,23552-74-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18069/7/4/2/?documentUUID=0dbc00e3-e68b-488f-93ed-e67fca9a3ac4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C(=C1NC2=C3C(=C(C=C2)NC4=C(C(=C(C=C4C)C)S(=O)(=O)NC5CCCCC5)C)C(=O)C6=CC=CC=C6C3=O)C)S(=O)(=O)NC7CCCCC7)C,https://pubchem.ncbi.nlm.nih.gov/compound/90157,PubChem,Cc1cc(C)c(S(=O)(=O)NC2CCCCC2)c(C)c1Nc1ccc(Nc2c(C)cc(C)c(S(=O)(=O)NC3CCCCC3)c2C)c2c1C(=O)c1ccccc1C2=O,Train,1,2702,training
-"JP_CHRIP:
-Dimethyl 4,4'-(o-phenylene)bis(3-thioallophanate) (synonym: Thiophanate-methyl)","JP_CHRIP:
-Thiophanate methyl
-Thiophanate-methyl",23564-05-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2017.html,"JP_CHRIP:
-【分類根拠】
-（１）、（２）より、区分に該当しない。
-
-【根拠データ】
-（１）ウサギ（n=6）を用いた皮膚刺激性試験（OECD TG 404相当、GLP、閉塞、4時間適用、72時間観察）において、全例で皮膚刺激性反応はみられなかった（紅斑・痂皮スコア：0/0/0/0/0/0、浮腫スコア：0/0/0/0/0/0）との報告がある（ECHA RAC Opinion (2019)、CLH Report (2018)、REACH登録情報 (Accessed Aug. 2021)）。
-（２）本物質は皮膚刺激性物質ではない（EFSA (2018)、JMPR (2017)、EPA Pesticides (2005)）。",Provided,JP_CHRIP,1,COC(=O)NC(=S)Nc1ccccc1NC(=S)NC(=O)OC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.471A,J-GLOBAL,COC(=O)NC(=S)Nc1ccccc1NC(=S)NC(=O)OC,Train,1,2702,training
-"NZ_CCID:
-2-Propenoic acid, 2-methyl-, oxydi-2,1-ethanediyl ester",,2358-84-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FD7D9D7D-0D81-4787-8CB7-CC18D020919B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,CC(=C)C(=O)OCCOCCOC(=O)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/16891,PubChem,C=C(C)C(=O)OCCOCCOC(=O)C(=C)C,Train,1,2702,training
-"NZ_CCID:
-Clotrimazole",,23593-75-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/18CCA3BB-FDD9-4418-8AD9-3E47A88C59BA,"NZ_CCID:
-Skin Irritation
-REMARK: Causes
-Skin Irritation. [Sigma-aldrich msds]
-Eye Irritation
-SPECIES:
-RESULT: Causes
-Eye Irritation.
-REFERENCE SOURCE: [Sigma-aldrich msds]",,NZ_CCID,1,C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CN=C4,https://pubchem.ncbi.nlm.nih.gov/compound/2812,PubChem,Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1,Train,1,2702,training
-"NZ_CCID:
-Methyl thioglycolate",,2365-48-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AAE91BA1-B6A9-4C96-8B14-5F7019AFC9A8,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,COC(=O)CS,https://pubchem.ncbi.nlm.nih.gov/compound/16907,PubChem,COC(=O)CS,Train,1,2702,training
-"EU_REACH:
-tert-butoxy propan-2-yl carbonate",,2372-21-6,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23536/7/4/2/?documentUUID=bbc60f32-b4eb-444a-8ee1-11ee756a001c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)OC(=O)OOC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/75406,PubChem,CC(C)OC(=O)OOC(C)(C)C,Train,1,2702,training
-"EU_REACH:
-bis(3-aminopropyl)(dodecyl)amine
-
-KR_NCIS:
-N1-(3-Aminopropyl)-N1-dodecyl-1,3-propanediamine
-
-NZ_CCID:
-1,3-Propanediamine, N-(3-aminopropyl)-N-dodecyl-",,2372-82-9,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5949/7/4/2/?documentUUID=6ea236a2-6c54-42f6-af1b-e60f792b049a
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D2A24768-7738-4823-BADF-4B2AAAA2B955","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",Provided,"EU_REACH, KR_NCIS, NZ_CCID",3,CCCCCCCCCCCCN(CCCN)CCCN,https://pubchem.ncbi.nlm.nih.gov/compound/75407,PubChem,CCCCCCCCCCCCN(CCCN)CCCN,Train,1,2702,training
-"EU_CLP:
-hydroxyphosphonoacetic acid",,23783-26-8,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,OC(C(O)=O)[P](O)(O)=O,https://cactus.nci.nih.gov/chemical/structure/23783-26-8/smiles,CACTUS,O=C(O)C(O)P(=O)(O)O,Test,1,2702,training
-"US_HSDB:
-1-Methylpyrene",,2381-21-7,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/2162,,,US_HSDB,1,CC1=C2C=CC3=CC=CC4=C3C2=C(C=C1)C=C4,https://pubchem.ncbi.nlm.nih.gov/compound/16932,PubChem,Cc1ccc2ccc3cccc4ccc1c2c34,Train,1,2702,training
-"EU_REACH:
-2-benzoyl-5-[3-(4-benzoyl-3-hydroxyphenoxy)-2-hydroxypropoxy]phenol",,23911-85-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13490/7/4/2/?documentUUID=cff04efc-ac6d-476d-bd07-3c3a37ef09cb,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C(=O)C2=C(C=C(C=C2)OCC(COC3=CC(=C(C=C3)C(=O)C4=CC=CC=C4)O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/1242235,PubChem,O=C(c1ccccc1)c1ccc(OCC(O)COc2ccc(C(=O)c3ccccc3)c(O)c2)cc1O,Train,1,2702,training
-"EU_REACH:
-ethyl (2S,3R)-2-amino-3-hydroxybutanoate",,23926-51-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31918/7/4/2/?documentUUID=023e38db-ba21-4116-80a7-027e3bbb6365,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)[C@H]([C@@H](C)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/2763097,PubChem,CCOC(=O)[C@@H](N)[C@@H](C)O,Train,1,2702,training
-"NZ_CCID:
-4-Methoxybenzylamine",,2393-23-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EC35F88A-8B6A-4F39-9F7F-CA2763E98208,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,COC1=CC=C(C=C1)CN,https://pubchem.ncbi.nlm.nih.gov/compound/75452,PubChem,COc1ccc(CN)cc1,Train,1,2702,training
-"NZ_CCID:
-Tolnaftate",,2398-96-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DEB79CB7-E573-46E9-930A-C5A9635C2BAC,"NZ_CCID:
-Skin Irritation
-REMARK: Confidential information supplied by registrant.
-Eye Irritation
-REMARK: Confidential information supplied by registrant.",,NZ_CCID,1,CC1=CC(=CC=C1)N(C)C(=S)OC2=CC3=CC=CC=C3C=C2,https://pubchem.ncbi.nlm.nih.gov/compound/5510,PubChem,Cc1cccc(N(C)C(=S)Oc2ccc3ccccc3c2)c1,Train,1,2702,training
-"EU_REACH:
-tetrahydrofuran-2-ylmethyl acrylate",,2399-48-6,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20149/7/4/2/?documentUUID=4075575d-14d7-494a-b943-18bbfa6d710f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CC(=O)OCC1CCCO1,https://pubchem.ncbi.nlm.nih.gov/compound/94232,PubChem,C=CC(=O)OCC1CCCO1,Train,1,2702,training
-"EU_REACH:
-2,2,6,6-tetramethylpiperidin-4-ol
-
-JP_CHRIP:
-2,2,6,6-Tetramethylpiperidin-4-ol
-
-NZ_CCID:
-2,2,6,6-Tetramethyl-4-piperidinol","JP_CHRIP:
-2,2,6,6-tetramethylpiperidin-4-ol
-2,2,6,6-tetramethylpiperidin-4-ol (synonym:2,2,6,6-tetramethyl-4-hydroxypiperidine)
-4-hydroxy-2,2,6,6-tetramethylpiperidine
-4-Piperidinol, 2,2,6,6-tetramethyl-",2403-88-5,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14709/7/4/2/?documentUUID=720157c5-76b2-4d73-9cd9-e14dce021d2c
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-0050e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DCEB6C1B-B5BF-471D-8012-26274E02EDA0","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-It was classified in Category 1 because it is described that a skin irritation test with rabbits (OECD TG 404) resulted in severe irritation (SIDS (2003)), and one of the animals did not recover even after 14 days (SIDS (2003)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,CC1(C)CC(O)CC(C)(C)N1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J39.108E,J-GLOBAL,CC1(C)CC(O)CC(C)(C)N1,Train,1,2702,training
-"EU_REACH:
-5-chlorothiophene-2-carboxylic acid",,24065-33-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23889/7/4/2/?documentUUID=33965c7d-da5b-4f0c-9977-99c8b79439a0,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(SC(=C1)Cl)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/95048,PubChem,O=C(O)c1ccc(Cl)s1,Train,1,2702,training
-"JP_CHRIP:
-2-tert-Butyl-p-cresol
-
-NZ_CCID:
-2-t-Butyl-4-methylphenol","JP_CHRIP:
-2-tert-butyl-4-methylphenol
-
-NZ_CCID:
-2-tert-butyl-4-methylphenol",2409-55-4,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0116e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FF61B5C2-4DB1-452B-B514-D31DA2C1FDFA","JP_CHRIP:
-It was classified in Category 2 because it was highly irritating in a test in which 2 mg was applied to the rabbit skin for 24 hours (IUCLID (2000)).
-
-NZ_CCID:
-Skin Irritation
-R-PHRASE: R 38. [Company data]
-Eye Irritation
-R-PHRASE: R 36. [Company data]",,"JP_CHRIP, NZ_CCID",2,Cc1ccc(O)c(c1)C(C)(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J48.502K,J-GLOBAL,Cc1ccc(O)c(C(C)(C)C)c1,Train,1,2702,training
-"JP_CHRIP:
-2,3,6-Trimethylphenol",,2416-94-6,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0076e.html,"JP_CHRIP:
-The substance was classified as Category 2 based on the documented case of ""irritating"" resulted from rabbit test (OECD TG 404) (IUCLID (2000)).",Provided,JP_CHRIP,1,Cc1ccc(C)c(O)c1C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J116.743J,J-GLOBAL,Cc1ccc(C)c(O)c1C,Train,1,2702,training
-"EU_REACH:
-6-methyloct-5-en-2-one",,24199-46-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12003/7/4/2/?documentUUID=32ab691d-e726-4035-9207-66ed86823bfe,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC/C(=C/CCC(=O)C)/C,https://pubchem.ncbi.nlm.nih.gov/compound/5363290,PubChem,CC/C(C)=C/CCC(C)=O,Train,1,2702,training
-"EU_REACH:
-2-hexyldecan-1-ol",,2425-77-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5585/7/4/2/?documentUUID=99c7899a-ae82-48ec-8a51-4917a873ab5b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCC(CCCCCC)CO,https://pubchem.ncbi.nlm.nih.gov/compound/95337,PubChem,CCCCCCCCC(CO)CCCCCC,Train,1,2702,training
-"JP_CHRIP:
-1,4-Butanediol diglycidyl ether
-
-NZ_CCID:
-Butanediol diglycidyl ether","JP_CHRIP:
-1,4-Butanediol diglycidyl ether
-1,4-Bis(2,3-epoxypropoxy) butane
-1,4-bis(2,3-epoxypropoxy)butane
-1,4-Bis(oxiranylmethyloxy)butane; 2,2'-[1,4-Butanediylbis(oxymethylene)]bis[oxirane]
-1,4-Butane diglycidyl ether
-
-NZ_CCID:
-(TETRAMETHYLENEBIS(OXYMETHYLENE))DIOXIRANE, 1,4-BIS(2,3-EPOXYPROPYLOXY)BUTANE, 1,4-BIS(GLYCIDYLOXY)BUTANE, 1,4-BUTANE DIGLYCIDYL ETHER, 1,4-DIGLYCIDYLOXYBUTANE, BUTANE, 1,4-BIS(2,3-EPOXYPROPOXY)-, TETRAMETHYLENE GLYCOL DIGLYCIDYL ETHER",2425-79-8,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2073e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BB4D330B-FDFC-42A0-8440-F8B086BD1175","JP_CHRIP:
-While it was reported that this substance was not irritating in a skin irritation test with rabbits (OECD TG 404 compliant) (PATTY (6th, 2012)), it was reported from other skin irritation tests with rabbits that moderate to severe irritation was observed after an occlusive application for 24 hours, and that extreme irritation was observed after five daily consecutive applications (PATTY (6th, 2012)). Because consecutive applications produced irritation of moderate or greater severity, this substance was considered to be irritating and classified in Category 2. Besides, this substance was classified as ""Skin Irrit. 2, H315"" in the EU CLP classification (ECHA CL Inventory (Access on June 2017)). By reviewing the content of the information sources, the category was changed.
-
-NZ_CCID:
-Skin Irritation
-R-PHRASE: R 36/38 Irritating to eyes and skin. [N-CLASS]
-Eye Irritation
-R-PHRASE: R 36/38 Irritating to eyes and skin. [N-CLASS]",Provided,"JP_CHRIP, NZ_CCID",2,C(CCOCC1CO1)COCC1CO1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J42.721G,J-GLOBAL,C(CCOCC1CO1)COCC1CO1,Train,1,2702,training
-"NZ_CCID:
-1,2,7,8-Diepoxyoctane",,2426-07-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F6FF0B9A-0B36-4B65-BD57-477D5BDD4F1B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1C(O1)CCCCC2CO2,https://pubchem.ncbi.nlm.nih.gov/compound/17048,PubChem,C(CCC1CO1)CC1CO1,Train,1,2702,training
-"AU_HCIS:
-butyl glycidyl ether
-
-JP_CHRIP:
-n-Butyl 2,3-epoxypropyl ether
-
-KR_NCIS:
-(Butoxymethyl)oxirane
-
-NZ_CCID:
-Butyl glycidyl ether","AU_HCIS:
-butyl 2,3-epoxypropyl ether
-Oxirane, (butoxymethyl)-
-
-JP_CHRIP:
-1-Butoxy-2,3-epoxypropane
-(Butoxymethyl)oxirane
-1-Butoxy-2,3-epoxypropane
-2,3-Epoxypropyl butyl ether
-BGE
-butyl glycidyl ether
-n-Butyl 2,3-epoxypropyl ether
-Oxirane, (butoxymethyl)-
-
-KR_NCIS:
-BGE; 1-Butoxy-2,3-epoxypropane; 2,3-Epoxypropyl butyl ether; Butyl 2,3-epoxypropyl ether; 2-(Butoxymethyl)oxirane",2426-08-6,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=716
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0100e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D43D1CD5-EF14-4987-BC43-036B0E38C16A","JP_CHRIP:
-As for effects on humans, since it is described that it is irritating to the skin (ACGIH (7th, 2001), DFGOT vol.4 (1992), PATTY (6th, 2001)), this substance was classified in Category 2.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Moderate (Draize scale 3.3)
-REFERENCE SOURCE: Clayton, G. D. and F. E. Clayton (eds.). Pattys Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982.2202]**PEER REVIEWED**
-[HSDB]
-
-Eye Irritation
-SPECIES:
-RESULT: Mild
-REFERENCE SOURCE: Sax, N.I. and R.J. Lewis, Sr. (eds.). Hawleys Condensed Chemical Dictionary. 11th ed. New York: Van Nostrand Reinhold Co., 1987.187 **PEER REVIEWED**",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID",4,CCCCOCC1CO1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J35.202K,J-GLOBAL,CCCCOCC1CO1,Train,1,2702,training
-"EU_CLP:
-2,6-dichloro-4-trifluoromethylaniline",,24279-39-8,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=C(C=C(C(=C1Cl)N)Cl)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/141094,PubChem,Nc1c(Cl)cc(C(F)(F)F)cc1Cl,Test,1,2702,training
-"JP_CHRIP:
-2,3,4-Trichloro-1-butene","JP_CHRIP:
-2,3,4-Trichlorobutene-1",2431-50-7,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0039e.html,"JP_CHRIP:
-It was classified in Category 2 because irritation was observed in a test in humans (SIDS (Access on June 2012)), and it was classified in Xi; R36/37/38 in EU classification (EC-JRC (ESIS) (Access on June 2012)).",,JP_CHRIP,1,ClCC(Cl)C(=C)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J70.087H,J-GLOBAL,C=C(Cl)C(Cl)CCl,Train,1,2702,training
-"NZ_CCID:
-2,2'-Dinitrobiphenyl",,2436-96-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AF77796A-7326-4900-BE4F-145D4337D2E0,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)C2=CC=CC=C2[N+](=O)[O-])[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/75529,PubChem,O=[N+]([O-])c1ccccc1-c1ccccc1[N+](=O)[O-],Train,1,2702,training
-"KR_NCIS:
-Dodecanenitrile",,2437-25-4,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCCCCCCCCCCC#N,https://pubchem.ncbi.nlm.nih.gov/compound/17092,PubChem,CCCCCCCCCCCC#N,Train,1,2702,training
-"EU_REACH:
-1,3-dimethoxy-1,3-dihydro-2-benzofuran",,24388-70-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24867/7/4/2/?documentUUID=cf9d737d-808c-43c0-8b68-969311731a4d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1C2=CC=CC=C2C(O1)OC,https://pubchem.ncbi.nlm.nih.gov/compound/11629690,PubChem,COC1OC(OC)c2ccccc21,Train,1,2702,training
-"JP_CHRIP:
-2-(Dimethylamino)ethyl acrylate","JP_CHRIP:
-dimethylamino ethyl acrylate
-Dimethylaminoethyl acrylate; 2-Propenoic acid, 2-(dimethylamino)ethyl ester",2439-35-2,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-2017e.html,"JP_CHRIP:
-In a test in which 0.5 mL of the undiluted test substance was applied to six rabbits for 4 hours (OECD TG 404), corrosivity was seen in all the animals, and the primary dermal irritation index (PDII) was 8 (SIDS (2003)). Therefore, it was classified in Category 1. Besides, other than the above, results of two Draize tests with rabbits were reported, PII was 8 and 7.6, and it was assessed as corrosive in both (SIDS (2003)).",Provided,JP_CHRIP,1,CN(C)CCOC(=O)C=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J38.142J,J-GLOBAL,C=CC(=O)OCCN(C)C,Train,1,2702,training
-"EU_CLP:
-2-bromo-2-nitropropanol",,24403-04-1,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(CO)([N+](=O)[O-])Br,https://pubchem.ncbi.nlm.nih.gov/compound/205966,PubChem,CC(Br)(CO)[N+](=O)[O-],Test,1,2702,training
-"EU_REACH:
-2-hexadecanamidoacetic acid",,2441-41-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21392/7/4/2/?documentUUID=419ebf10-9572-4785-8ce4-1134ed908e0e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCC(=O)NCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/151008,PubChem,CCCCCCCCCCCCCCCC(=O)NCC(=O)O,Train,1,2702,training
-"NZ_CCID:
-Di(t-butyl) carbonate","NZ_CCID:
-di-tert-butyl dicarbonate",24424-99-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4897F892-70F5-4ABF-8D96-7F7D230D2E4E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/90495,PubChem,CC(C)(C)OC(=O)OC(=O)OC(C)(C)C,Train,1,2702,training
-"NZ_CCID:
-2-Chlorophenylacetic acid",,2444-36-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8D84CFD3-E84B-482D-84A5-CDC3679B14E9,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)CC(=O)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/17124,PubChem,O=C(O)Cc1ccccc1Cl,Train,1,2702,training
-"NZ_CCID:
-Diisopropylazodicarboxylate","NZ_CCID:
-diisopropyl azodicarboxylate",2446-83-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AC483609-2559-4A8D-8925-2B9D4189831C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(C)OC(=O)N=NC(=O)OC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/75555,PubChem,CC(C)OC(=O)N=NC(=O)OC(C)C,Train,1,2702,training
-"EU_REACH:
-2-Methyl-3-methoxy benzoyl chloride",,24487-91-0,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/28358/7/4/2/?documentUUID=0a0590d9-a6e3-4429-87fa-594e250ff664,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=CC=C1OC)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/14719554,PubChem,COc1cccc(C(=O)Cl)c1C,Train,1,2702,training
-"EU_REACH:
-2,6-bis(propan-2-yl)aniline",,24544-04-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10001/7/4/2/?documentUUID=a32ab69e-3794-402c-a9d0-53e19bb3950a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1=C(C(=CC=C1)C(C)C)N,https://pubchem.ncbi.nlm.nih.gov/compound/32484,PubChem,CC(C)c1cccc(C(C)C)c1N,Train,1,2702,training
-"EU_REACH:
-2,6-diethyl-4-methylaniline",,24544-08-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10873/7/4/2/?documentUUID=b2d60ef5-18d1-486e-8449-998969542de1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1=CC(=CC(=C1N)CC)C,https://pubchem.ncbi.nlm.nih.gov/compound/90536,PubChem,CCc1cc(C)cc(CC)c1N,Train,1,2702,training
-"EU_REACH:
-2-ethyl-6-methylaniline",,24549-06-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12644/7/4/2/?documentUUID=8689db96-ca10-42cd-9e11-70da7bf74ab8,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1=CC=CC(=C1N)C,https://pubchem.ncbi.nlm.nih.gov/compound/32485,PubChem,CCc1cccc(C)c1N,Train,1,2702,training
-"NZ_CCID:
-4-(1-Pyrrolidinyl) pyridine","NZ_CCID:
-4-pyrrolidinopyridine",2456-81-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/62EDDD3C-3D58-40B5-B2BD-31EB7EB5FB7C,"NZ_CCID:
-Skin Irritation
-UN CLASS: 8; Packing Group II.
-Eye Irritation
-R PHRASE: R 35 [Company Data]",,NZ_CCID,1,C1CCN(C1)C2=CC=NC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/75567,PubChem,c1cc(N2CCCC2)ccn1,Train,1,2702,training
-"NZ_CCID:
-2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl) acetamide","NZ_CCID:
-N-methyl-N-(trimethylsilyl)trifluoroacetamide",24589-78-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/30C19FA7-C956-4FC0-BFFC-D221D774BE55,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CN(C(=O)C(F)(F)F)[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/32510,PubChem,CN(C(=O)C(F)(F)F)[Si](C)(C)C,Train,1,2702,training
-"EU_CLP:
-tridemorph (ISO); 2,6-dimethyl-4-tridecylmorpholine",,24602-86-6,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCCCCCCCCCCCCN1CC(OC(C1)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/32518,PubChem,CCCCCCCCCCCCCN1CC(C)OC(C)C1,Test,1,2702,training
-"EU_REACH:
-2-[[4-[(2-cyanoethyl)(2-phenylethyl)amino]phenyl]azo]-5-nitrobenzonitrile",,24610-00-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24978/7/4/2/?documentUUID=3d9995c1-1304-4d79-b30d-c5d909e5c228,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)CCN(CCC#N)C2=CC=C(C=C2)N=NC3=C(C=C(C=C3)[N+](=O)[O-])C#N,https://pubchem.ncbi.nlm.nih.gov/compound/90555,PubChem,N#CCCN(CCc1ccccc1)c1ccc(N=Nc2ccc([N+](=O)[O-])cc2C#N)cc1,Train,1,2702,training
-"NZ_CCID:
-2-Propenoic acid, 2-carboxyethyl ester",,24615-84-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/705E6D33-4D11-4698-BC20-4388F403E6C0,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,C=CC(=O)OCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/90558,PubChem,C=CC(=O)OCCC(=O)O,Train,1,2702,training
-"KR_NCIS:
-3-(Chlorodimethylsilyl)propyl 2-methyl-2-propenoate",,24636-31-5,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CC(=C)C(=O)OCCC[Si](C)(C)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/2759527,PubChem,C=C(C)C(=O)OCCC[Si](C)(C)Cl,Train,1,2702,training
-"EU_REACH:
-tris(2-ethylhexyl) borate",,2467-13-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17438/7/4/2/?documentUUID=603c4086-a006-45a3-8818-7f3631a456f0,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,B(OCC(CC)CCCC)(OCC(CC)CCCC)OCC(CC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/17177,PubChem,CCCCC(CC)COB(OCC(CC)CCCC)OCC(CC)CCCC,Train,1,2702,training
-"EU_REACH:
-3-[(4-{2-[2-bromo-4-nitro-6-(trifluoromethyl)phenyl]diazen-1-yl}phenyl)(2-cyanoethyl)amino]propanenitrile",,246871-16-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15680/7/4/2/?documentUUID=8e3a15ea-2c7c-4d73-a780-0744c01395ce,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1N=NC2=C(C=C(C=C2Br)[N+](=O)[O-])C(F)(F)F)N(CCC#N)CCC#N,https://pubchem.ncbi.nlm.nih.gov/compound/11340904,PubChem,N#CCCN(CCC#N)c1ccc(N=Nc2c(Br)cc([N+](=O)[O-])cc2C(F)(F)F)cc1,Train,1,2702,training
-"EU_REACH:
-3-oxo-N-[4-(3-oxobutanamido)phenyl]butanamide",,24731-73-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5230/7/4/2/?documentUUID=eb1b79d0-9054-4b85-82a1-44bdb74845dd,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)CC(=O)NC1=CC=C(C=C1)NC(=O)CC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/90595,PubChem,CC(=O)CC(=O)Nc1ccc(NC(=O)CC(C)=O)cc1,Train,1,2702,training
-"AU_HCIS:
-1,4,5,8-tetraaminoanthraquinone","AU_HCIS:
-C.I. Disperse Blue 1
-9,10-Anthracenedione, 1,4,5,8-tetraamino-",2475-45-8,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4347,,,AU_HCIS,1,C1=CC(=C2C(=C1N)C(=O)C3=C(C=CC(=C3C2=O)N)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/17190,PubChem,Nc1ccc(N)c2c1C(=O)c1c(N)ccc(N)c1C2=O,Train,1,2702,training
-"EU_REACH:
-2-fluoro-5-methanesulfonylbenzoic acid",,247569-56-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5363/7/4/2/?documentUUID=8ec05912-2f46-453d-8603-a301b6abc2ea,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CS(=O)(=O)C1=CC(=C(C=C1)F)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/22467566,PubChem,CS(=O)(=O)c1ccc(F)c(C(=O)O)c1,Train,1,2702,training
-"JP_CHRIP:
-Methyl(2-pentyl-3-oxocyclopentyl)acetate","JP_CHRIP:
-Cyclopentaneacetic acid, 3-oxo-2-pentyl-, methyl ester; Methyl dihydrojasmonate
-methyl (2-pentyl-3-oxo-cyclopentyl)acetate
-methyl 3-oxo-2-pentylcyclopentaneacetate
-methyl 3-oxo-2-pentylcyclopentylacetate",24851-98-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0068e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified as ""Not classified"" from (1) - (3).
-
-[Evidence Data]
-(1) It is reported that in a patch test in 111 persons, no skin irritation reactions were seen by a 20% solution of this substance (cis-: trans-isomer (about 10-12%: 88-90%)) (REACH registration dossier (Accessed Oct. 2020)).
-(2) It is reported that in a patch test in 100 persons, no skin irritation reactions were observed by a 20% solution of this substance (cis-: trans-isomer (about 75%: 25%)) (REACH registration dossier (Accessed Oct. 2020)).
-(3) It is reported that in a skin irritation test with rabbits (n = 3) on this substance (cis-: trans-isomer (about 30%: 70%)) (OECD TG 404, GLP, occlusive, 4-hour application, 72-hour observation), no skin irritation reactions were found in any animal (erythema/eschar score: 0/0/0, edema score: 0/0/0) (REACH registration dossier (Accessed Oct. 2020)).",Provided,JP_CHRIP,1,CCCCCC1C(CC(=O)OC)CCC1=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J87.287C,J-GLOBAL,CCCCCC1C(=O)CCC1CC(=O)OC,Train,1,2702,training
-"EU_REACH:
-dec-1-en-4-yne",,24948-66-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32054/7/4/2/?documentUUID=82493ce3-1045-4cec-9d1a-9457dcd27018,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCC#CCC=C,https://pubchem.ncbi.nlm.nih.gov/compound/4321798,PubChem,C=CCC#CCCCCC,Train,1,2702,training
-"NZ_CCID:
-2,6-Dichlorothiophenol","NZ_CCID:
-2,6-dichlorobenzenethiol",24966-39-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/08CD11E2-39CE-4FD3-95A7-A4B8F3C95EBC,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C(=C1)Cl)S)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/90671,PubChem,Sc1c(Cl)cccc1Cl,Train,1,2702,training
-"EU_CLP:
-hexyl acrylate",,2499-95-8,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCCCCCOC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/17259,PubChem,C=CC(=O)OCCCCCC,Test,1,2702,training
-"EU_REACH:
-dioctadecyl disulphide",,2500-88-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32156/7/4/2/?documentUUID=5ed54a72-427e-4cdc-bbb0-993012593d8f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCCCSSCCCCCCCCCCCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/75627,PubChem,CCCCCCCCCCCCCCCCCCSSCCCCCCCCCCCCCCCCCC,Train,1,2702,training
-"EU_REACH:
-2-methylundecane-2-thiol
-
-JP_CHRIP:
-tert-Dodecanethiol
-
-NZ_CCID:
-t-Dodecanethiol","NZ_CCID:
-Tert-dodecanethiol, tert-dodecyl mercaptan",25103-58-6,Cat 2,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13431/7/4/2/?documentUUID=687c7175-8d5c-4856-b957-a0aacc776387
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-meti-0009e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/43CE0EF8-FCDD-47AF-AF41-F9324DDD7845","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-It is reported that in a skin irritation test (OECD TG 404) using rabbits, as a result of a semi-occlusive application with an undiluted solution of this substance for 4 hours, it was irritating since well-defined or moderate erythema and slight to moderate erythema were observed (SIDS (2014)). Moreover, it is reported that in another irritation study using rabbits, irritation was observed after 4-hour application (PATTY (6th, 2012)).
-From the above, this substance was classified in Category 2.
-The information of IUCLID used in the previous classification could not be confirmed because it was not available. The classification was revised because of the updated information.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,CC(C)C(C)(C)C(C)(C)C(C)(C)S,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J76.265B,J-GLOBAL,CC(C)C(C)(C)C(C)(C)C(C)(C)S,Train,1,2702,training
-"EU_REACH:
-2-[(4-methyl-2-nitrophenyl)diazenyl]-3-oxo-N-phenylbutanamide",,2512-29-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13177/7/4/2/?documentUUID=577b01fb-5553-4f7b-bfae-c6c9f5a8175c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)N=NC(C(=O)C)C(=O)NC2=CC=CC=C2)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/221491,PubChem,CC(=O)C(N=Nc1ccc(C)cc1[N+](=O)[O-])C(=O)Nc1ccccc1,Train,1,2702,training
-"EU_CLP:
-ethylene bis(trichloroacetate)",,2514-53-6,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C(COC(=O)C(Cl)(Cl)Cl)OC(=O)C(Cl)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/17284,PubChem,O=C(OCCOC(=O)C(Cl)(Cl)Cl)C(Cl)(Cl)Cl,Test,1,2702,training
-"EU_REACH:
-2,4,4-trimethylpent-1-ene",,25167-70-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14774/7/4/2/?documentUUID=52e4d721-4981-45cd-9c05-92219da36d85,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)CC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/7868,PubChem,C=C(C)CC(C)(C)C,Train,1,2702,training
-"NZ_CCID:
-5-Chloro-2-nitrobenzoic acid",,2516-95-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/318E3A5E-D2E3-44AC-9443-196CBDEB11AF,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C=C1Cl)C(=O)O)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/17286,PubChem,O=C(O)c1cc(Cl)ccc1[N+](=O)[O-],Train,1,2702,training
-"NZ_CCID:
-2-Chloro-5-nitrobenzoic acid",,2516-96-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7D1990D1-1036-4399-9134-AFB72CB691E8,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C=C1[N+](=O)[O-])C(=O)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/17287,PubChem,O=C(O)c1cc([N+](=O)[O-])ccc1Cl,Train,1,2702,training
-"EU_REACH:
-3-methoxybutan-1-ol",,2517-43-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5155/7/4/2/?documentUUID=7331f061-6223-4a3d-b8c8-86f2874e7938,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CCO)OC,https://pubchem.ncbi.nlm.nih.gov/compound/17291,PubChem,COC(C)CCO,Train,1,2702,training
-"EU_REACH:
-unnamed [252285-60-2]",,252285-60-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11244/7/4/2/?documentUUID=54e6ef13-f4f6-40cd-a7a3-c2b3d18f377d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=CC=C(C=C1)C2=NC(=NC(=N2)C3=CC=CC=C3)C4=CC=CC=C4O,https://pubchem.ncbi.nlm.nih.gov/compound/136146573,PubChem,CCOc1ccc(-c2nc(-c3ccccc3)nc(-c3ccccc3O)n2)cc1,Train,1,2702,training
-"JP_CHRIP:
-O,O-Dimethylchlorothiophosphonate","JP_CHRIP:
-O,O-Dimethyl chlorothiophosphonate
-O,O-Dimethyl phosphorochloridothioate",2524-03-0,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0115e.html,"JP_CHRIP:
-Since ""highly irritating"" after 4-hour application and ""corrosive"" after 24-hour application were reported in a rabbit Draize test (IUCLID (2000)), the substance was classified into Category 2 based on the result after a 4-hour application.",,JP_CHRIP,1,COP(=S)(Cl)OC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J113.023D,J-GLOBAL,COP(=S)(Cl)OC,Train,1,2702,training
-"JP_CHRIP:
-Diethyl chlorothiophosphonate","JP_CHRIP:
-Diethyl chlorothiophosphate
-Diethyl phosphochloridothionate
-Phosphorochloridothioic acid O,O-diethylester",2524-04-1,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0204e.html,"JP_CHRIP:
-The substance was classified as Category 1 based on the document that the substance caused irritation after 3 minutes of application and caused corrosion after 1 hour of application in the rabbit test (OECD TG404).",Provided,JP_CHRIP,1,CCOP(=S)(Cl)OCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.649G,J-GLOBAL,CCOP(=S)(Cl)OCC,Train,1,2702,training
-"NZ_CCID:
-Diphenyl phosphorochloridate","NZ_CCID:
-diphenyl chlorophosphate",2524-64-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/91C88312-D106-496B-8FBD-71A44271F05D,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)OP(=O)(OC2=CC=CC=C2)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/75654,PubChem,O=P(Cl)(Oc1ccccc1)Oc1ccccc1,Train,1,2702,training
-"ChemSkin:
-Dipropylene glycol",,25265-71-8,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,CCC(O)OC(O)CC,https://cactus.nci.nih.gov/chemical/structure/25265-71-8/smiles,CACTUS,CCC(O)OC(O)CC,Test,1,2702,training
-"AU_HCIS:
-1,2-Benzisothiazol-3(2H)-one, 2-methyl-
-
-KR_NCIS:
-2-Methyl-1,2-benzisothiazolin-3-one","KR_NCIS:
-2-methyl-1,2-benzisothiazol-3(2H)-one; 2-methyl-1,2-benzisothiazolin-3-one; 2-Methyl-1,2-benzoisothiazolin-3-one",2527-66-4,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=422
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,"AU_HCIS, KR_NCIS",2,CN1C(=O)C2=CC=CC=C2S1,https://pubchem.ncbi.nlm.nih.gov/compound/351236,PubChem,Cn1sc2ccccc2c1=O,Train,1,2702,training
-"EU_REACH:
-heptanoyl chloride",,2528-61-2,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13180/7/4/2/?documentUUID=265eb042-f695-4789-8905-622c1ba307c9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/17313,PubChem,CCCCCCC(=O)Cl,Test,1,2702,training
-"KR_NCIS:
-2,2'-(9-Octadecenylimino)bisethanol","KR_NCIS:
-2,2'-(9-Octadecenylimino)bisethanol; Ethanol, 2,2'-(9-octadecen-1-ylimino)bis-; Ethanol, 2,2'-(9-octadecenylimino)bis-; Ethanol, 2,2'-(9-octadecenylimino)di-",25307-17-9,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCCCCCCC/C=C/CCCCCCCCN(CCO)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/6537107,PubChem,CCCCCCCC/C=C/CCCCCCCCN(CCO)CCO,Train,1,2702,training
-"JP_CHRIP:
-2-{[3-(Trimethoxysilyl)propoxy]methyl}oxirane","JP_CHRIP:
-2-(6,6-Dimethoxy-2,7-dioxa-6-silaoctan-1-yl)oxirane
-[3-(2,3-epoxypropoxy)propyl]trimethoxysilane",2530-83-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0001e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified as ""Not classified"" from (1) - (3).
-
-[Evidence Data]
-(1) It is reported that in a skin irritation test with rabbits (n = 6) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 14-day observation), slight irritation was observed in all the animals, which resolved completely after 14 days (erythema/eschar score: 1.7/1.7/1.7/1/1/1.3, edema score: 1.3/0.3/0.3/0/0/0.3) (REACH registration dossier (Accessed May 2020)).
-(2) It is reported that in a skin irritation test with rabbits (n = 6) (semi-occlusive, 24-hour application, 96-hour observation), erythema was found in all the animals 24 and 48 hours after removal of patches and persisted for 96 hours, but no edema was seen (erythema/eschar score: 1.7/2/1.7/2/2/2, edema score: 0.7/0/0/0/0/0) (SIDS (2004), REACH registration dossier (Accessed May 2020)).
-(3) It is reported that in a skin irritation test with rabbits (n = 4) (semi-occlusive, 24-hour application, 72-hour observation), skin primary irritation index (PII) = 0.06 (Non-irritant) (SIDS (2004), REACH registration dossier (Accessed May 2020)).",Provided,JP_CHRIP,1,CO[Si](CCCOCC1CO1)(OC)OC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J48.152A,J-GLOBAL,CO[Si](CCCOCC1CO1)(OC)OC,Train,1,2702,training
-"NZ_CCID:
-Dimethylbenzenesulphonic acid",,25321-41-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D77558C3-0679-4B34-A89A-E0FE4B64D89B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,Cc1cccc(c1C)[S](O)(=O)=O,https://cactus.nci.nih.gov/chemical/structure/25321-41-9/smiles,CACTUS,Cc1cccc(S(=O)(=O)O)c1C,Train,1,2702,training
-"EU_REACH:
-1,2-diethylbenzene; 1,3-diethylbenzene; 1,4-diethylbenzene",,25340-17-4,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2100/7/4/2/?documentUUID=7c184481-ca58-4933-8d9b-e6edffbd3bf5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCc1ccccc1CC,https://cactus.nci.nih.gov/chemical/structure/25340-17-4/smiles,CACTUS,CCc1ccccc1CC,Train,1,2702,training
-"EU_REACH:
-2-hexyldecanoic acid",,25354-97-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27833/7/4/2/?documentUUID=b747aa5f-c2ca-41ab-ae95-1070b493c9e3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCC(CCCCCC)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/32912,PubChem,CCCCCCCCC(CCCCCC)C(=O)O,Train,1,2702,training
-"EU_REACH:
-3,5-dimethylheptane-3-thiol",,25360-10-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12041/7/4/2/?documentUUID=7f7fdf43-9631-4818-a971-882e6c8101ca,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCC(C)(C)S,https://pubchem.ncbi.nlm.nih.gov/compound/520196,PubChem,CCCCCCC(C)(C)S,Train,1,2702,training
-"NZ_CCID:
-Diethyl cyanomethylphosphonate",,2537-48-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5A6B591F-3576-44AF-98BB-67149857C8EA,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCOP(=O)(CC#N)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/75676,PubChem,CCOP(=O)(CC#N)OCC,Train,1,2702,training
-"EU_REACH:
-tridec-1-ene",,25377-82-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2007/7/4/2/?documentUUID=8dcfd306-3eb2-423f-a177-5f141bb0b0de,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCC/C=C/C,https://pubchem.ncbi.nlm.nih.gov/compound/5364435,PubChem,C/C=C/CCCCCCCCCC,Train,1,2702,training
-"NZ_CCID:
-1,3,5-Tribenzylhexahydro-1,3,5-triazine",,2547-66-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A3572900-4F67-497D-B93C-50C407C266B1,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1N(CN(CN1CC2=CC=CC=C2)CC3=CC=CC=C3)CC4=CC=CC=C4,https://pubchem.ncbi.nlm.nih.gov/compound/75685,PubChem,c1ccc(CN2CN(Cc3ccccc3)CN(Cc3ccccc3)C2)cc1,Train,1,2702,training
-"EU_REACH:
-ethenyl 2-chloroacetate",,2549-51-1,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24817/7/4/2/?documentUUID=fecbfc2a-79d2-4b4a-aeea-dd710dd109b4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=COC(=O)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/82156,PubChem,C=COC(=O)CCl,Train,1,2702,training
-"EU_REACH:
-tetradecyl methacrylate",,2549-53-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14692/7/4/2/?documentUUID=470e6cff-3a66-430b-a8a3-0c81a71ef768,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCOC(=O)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/17351,PubChem,C=C(C)C(=O)OCCCCCCCCCCCCCC,Train,1,2702,training
-"NZ_CCID:
-Benzylacetone","NZ_CCID:
-4-Phenyl-2-butanone, Methyl 2-phenylethyl ketone, Methyl phenethyl ketone, Methyl phenylethyl ketone",2550-26-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4CDDCF49-49DB-4C94-B626-2148C4FDB0A5,"NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Severe
-REFERENCE SOURCE: MSDS - www.conncoll.edu/offices/envhealth/MSDS/chemistry/B/benzylacetone.html.
-Eye Irritation
-R-PHRASE: R 36/37/38 Irritating to eyes, respiratory system and skin. [MSDS - www.conncoll.edu/offices/envhealth/MSDS/chemistry/B/benzylacetone.html]",,NZ_CCID,1,CC(=O)CCC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/17355,PubChem,CC(=O)CCc1ccccc1,Train,1,2702,training
-"ChemSkin:
-Cyclohexadecanone",,2550-52-9,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,C1CCCCCCCC(=O)CCCCCCC1,https://pubchem.ncbi.nlm.nih.gov/compound/75695,PubChem,O=C1CCCCCCCCCCCCCCC1,Test,1,2702,training
-"EU_REACH:
-2,2,4-trimethylhexane-1,6-diamine; 2,4,4-trimethylhexane-1,6-diamine",,25513-64-8,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21905/7/4/2/?documentUUID=85f760b6-eba2-4fa7-8cd0-e1ede5b1fc0b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CCN)CC(C)(C)CN,https://cactus.nci.nih.gov/chemical/structure/25513-64-8/smiles,CACTUS,CC(CCN)CC(C)(C)CN,Test,1,2702,training
-"EU_REACH:
-(Z)-tetrahydro-6-(2-pentenyl)-2H-pyran-2-one",,25524-95-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32953/7/4/2/?documentUUID=38f6f2f2-62c8-4c31-901b-ecf74e60f618,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC/C=C\CC1CCCC(=O)O1,https://pubchem.ncbi.nlm.nih.gov/compound/5352626,PubChem,CC/C=C\CC1CCCC(=O)O1,Train,1,2702,training
-"EU_REACH:
-tris(6-methylheptyl)amine",,25549-16-0,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23061/7/4/2/?documentUUID=98f7df3e-26c0-41a4-9fb8-b04e22606d58,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCN(CCCCCC(C)C)CCCCCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/75991,PubChem,CC(C)CCCCCN(CCCCCC(C)C)CCCCCC(C)C,Train,1,2702,training
-"EU_CLP:
-2-methyl-5-phenylpentanol",,25634-93-9,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(CCCC1=CC=CC=C1)CO,https://pubchem.ncbi.nlm.nih.gov/compound/5463791,PubChem,CC(CO)CCCc1ccccc1,Test,1,2702,training
-"KR_NCIS:
-(1-Methylethyl)-1,1'-biphenyl",,25640-78-2,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CC(C)C1=CC=CC=C1C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/123382,PubChem,CC(C)c1ccccc1-c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-2,2,6,6-Tetramethylpiperidine-1-oxyl",,2564-83-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/90BE00D1-E7A7-40A6-A4AC-881E32DC208B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC1(CCCC(N1[O])(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/2724126,PubChem,CC1(C)CCCC(C)(C)N1[O],Train,1,2702,training
-"EU_REACH:
-1-(butoxymethoxy)butane",,2568-90-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11620/7/4/2/?documentUUID=30f29525-342f-49f6-b96d-3a7793580a3d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOCOCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/17379,PubChem,CCCCOCOCCCC,Test,1,2702,training
-"NZ_CCID:
-2-Chloro-3,5-dinitropyridine",,2578-45-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DE4E0B71-B0E3-44A9-AF6B-5D298682D813,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=C(C=NC(=C1[N+](=O)[O-])Cl)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/75738,PubChem,O=[N+]([O-])c1cnc(Cl)c([N+](=O)[O-])c1,Train,1,2702,training
-"EU_REACH:
-1,3-Cyclohexanedimethanamine
-
-JP_CHRIP:
-1,3-Bis(aminomethyl)cyclohexane","JP_CHRIP:
-1,3-bis(aminomethyl)cyclohexane
-1,3-Bis(aminomethyl)cyclohexane; 1,3-Bis(aminomethyl)cyclohexane
-1,3-Cyclohexanedimethanamine",2579-20-6,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15661/7/4/2/?documentUUID=49923ed2-1d3c-461a-8411-ab74f599e52a
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0118e.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-In a skin irritation test in which 0.5 mL of the test substance was applied to one rabbit for 3 minutes, Draize irritation scores after 1 hour were 4 for erythema and 0 for edema, and green-colored necrosis, loss of elasticity, and dryness were observed in the skin, and it was assessed to be corrosive (NICNAS (2001)). Therefore, it was classified in Category 1A.",Provided,"EU_REACH, JP_CHRIP",2,NCC1CCCC(CN)C1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J48.534I,J-GLOBAL,NCC1CCCC(CN)C1,Train,1,2702,training
-"NZ_CCID:
-Gemfibrozil","NZ_CCID:
-5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid",25812-30-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/91F852FD-AA6B-4B77-BE75-2B71CB78784E,"NZ_CCID:
-Skin Irritation
-REMARK: Confidential information supplied by registrant
-Eye Irritation
-REMARK: Confidential information supplied by registrant",,NZ_CCID,1,CC1=CC(=C(C=C1)C)OCCCC(C)(C)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/3463,PubChem,Cc1ccc(C)c(OCCCC(C)(C)C(=O)O)c1,Train,1,2702,training
-"AU_HCIS:
-9,12-Octadecadien-1-amine, (Z,Z)-",,25876-34-0,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5635,,,AU_HCIS,1,CCCCC/C=C\C/C=C\CCCCCCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/6438044,PubChem,CCCCC/C=C\C/C=C\CCCCCCCCN,Train,1,2702,training
-"NZ_CCID:
-1-Formylpiperidine","NZ_CCID:
-N-Formylpiperidine",2591-86-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9496F4FB-5FB1-43FC-BB9E-B0DCEF228E2A,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 36/ 37/ 38. [Company data]
-Eye Irritation
-R-PHRASE: R 36/ 37/ 38. [Company data]",,NZ_CCID,1,C1CCN(CC1)C=O,https://pubchem.ncbi.nlm.nih.gov/compound/17429,PubChem,O=CN1CCCCC1,Train,1,2702,training
-"EU_REACH:
-triethoxy[3-(oxiran-2-ylmethoxy)propyl]silane",,2602-34-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14188/7/4/2/?documentUUID=68a1dcda-b1c5-4118-87e3-cc6c74818372,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](CCCOCC1CO1)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/102856,PubChem,CCO[Si](CCCOCC1CO1)(OCC)OCC,Train,1,2702,training
-"EU_REACH:
-1,2-bis(2-ethylhexyl) 3,4,5,6-tetrabromobenzene-1,2-dicarboxylate",,26040-51-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10235/7/4/2/?documentUUID=ee2de800-138e-4b34-98fb-1848c8685d64,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)C1=C(C(=C(C(=C1Br)Br)Br)Br)C(=O)OCC(CC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/117291,PubChem,CCCCC(CC)COC(=O)c1c(Br)c(Br)c(Br)c(Br)c1C(=O)OCC(CC)CCCC,Train,1,2702,training
-"EU_REACH:
-decyl(dimethyl)amine oxide",,2605-79-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5684/7/4/2/?documentUUID=8a3114d6-812b-4505-929f-3d8a27e01539,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCC[N+](C)(C)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/62452,PubChem,CCCCCCCCCC[N+](C)(C)[O-],Train,1,2702,training
-"EU_REACH:
-1-[({[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}carbonyl)oxy]propan-2-ol",,260781-16-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23304/7/4/2/?documentUUID=2bc355a1-3854-4656-a334-8c0575fdd981,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H]1CC[C@H]([C@@H](C1)OC(=O)OCC(C)O)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/57509244,PubChem,CC(O)COC(=O)O[C@@H]1C[C@H](C)CC[C@H]1C(C)C,Train,1,2702,training
-"NZ_CCID:
-Acridine","NZ_CCID:
-10-Azaanthracene, 2,3-Benzoquinoline, Dibenzo[b,e]pyridine",260-94-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B80C2549-3639-4ADB-934D-5E86182853DA,"NZ_CCID:
-Skin Irritation
-SPECIES:
-RESULT: Powerful irritant
-REFERENCE SOURCE: International Labour Office. Encyclopedia of Occupational Health and Safety. Volumes I and II. New York: McGraw-Hill Book Co., 1971. 32]**PEER REVIEWED** [HSDB]
-Eye Irritation
-SPECIES:
-RESULT: Powerful irritant
-REFERENCE SOURCE: International Labour Office. Encyclopedia of Occupational Health and Safety. Volumes I and II. New York: McGraw-Hill Book Co., 1971. 32]**PEER REVIEWED** [HSDB]",,NZ_CCID,1,C1=CC=C2C(=C1)C=C3C=CC=CC3=N2,https://pubchem.ncbi.nlm.nih.gov/compound/9215,PubChem,c1ccc2nc3ccccc3cc2c1,Train,1,2702,training
-"KR_NCIS:
-5-Chloro-2-methyl-4-isothiazolin-3-one
-
-NZ_CCID:
-4-Isothiazolin-3-one, 5-chloro-2-methyl-","NZ_CCID:
-5-Chloro-2-methyl-4-isothiazolin-3-one",26172-55-4,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/ACA62E2C-A773-45A4-8C04-603D11A5AD62","NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Corrosive
-REFERENCE SOURCE: THOR CHEMIE GMBH Speyer [iuclid 2000]
-REMARK: EC Classification: Corrosive (causes burns)
-CUTOFFS:
-8.2B Corrosive at 0.6% and above
-6.3A Irritant at 0.06% and above [[ECB for CAS # 55965-84-9]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Highly irritating
-REFERENCE SOURCE: THOR CHEMIE GMBH Speyer [IUCLID 2000]
-REMARK: EC Classification: Irritating
-CUTOFFS:
-8.3A Corrosive at 0.6% and above
-6.4A Irritant at 0.06% and above [ECB for CAS # 55965-84-9]",,"KR_NCIS, NZ_CCID",2,CN1C(=O)C=C(S1)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/33344,PubChem,Cn1sc(Cl)cc1=O,Train,1,2702,training
-"ChemSkin:
-2-Ethylhexyl-4-aminobenzoate",,26218-04-2,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,CCCCC(CC)COC(=O)C1=CC=C(C=C1)N,https://pubchem.ncbi.nlm.nih.gov/compound/11436614,PubChem,CCCCC(CC)COC(=O)c1ccc(N)cc1,Test,1,2702,training
-"NZ_CCID:
-Sorbitan trioleate","NZ_CCID:
-Anhydrosorbitol trioleate, Emsorb 2503, Glycomul TO, Liposorb TO, Nissan nonion OP 85R, Rheodol SP 030, Span 85",26266-58-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/415A8580-2B4B-4519-B6F9-989FFE1D783D,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [sigma aldrich msds]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Mild irritation.
-REFERENCE SOURCE: [sigma aldrich msds]",,NZ_CCID,1,CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@@H](O)[C@@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC,https://cactus.nci.nih.gov/chemical/structure/26266-58-0/smiles,CACTUS,CCCCCCCC/C=C\CCCCCCCC(=O)OCC(OC(=O)CCCCCCC/C=C\CCCCCCCC)[C@H]1OC[C@@H](O)[C@@H]1OC(=O)CCCCCCC/C=C\CCCCCCCC,Train,1,2702,training
-"EU_CLP:
-styrene-4-sulfonyl chloride",,2633-67-2,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C=CC1=CC=C(C=C1)S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/9855777,PubChem,C=Cc1ccc(S(=O)(=O)Cl)cc1,Test,1,2702,training
-"AU_HCIS:
-1,2-benzisothiazol-3(2H)-one
-
-JP_CHRIP:
-1,2-Benzothiazolin-3-one
-
-KR_NCIS:
-1,2-Benzisothiazol-3(2H)-one
-
-NZ_CCID:
-1,2-Benzisothiazol-3(2H)-one
-
-US_HSDB:
-1,2-Benzisothiazoline-3-one","AU_HCIS:
-1,2-benzisothiazolin-3-one
-
-JP_CHRIP:
-1,2-benzoisothiazole-3(2H)-one
-1,2-benzothiazole-3(2H)-one
-1,2-benzothiazolin-3-one
-
-KR_NCIS:
-1,2-Benzisothiazol-3-ol; 3-Hydroxy-1,2-benzisothiazole; Benzisothiazolone; Benzocil; Proxel AB
-
-NZ_CCID:
-1,2-Benzisothiazolin-3-one, BIT",2634-33-5,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=423
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0090e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E0996264-5E87-464F-ADD7-5374D5AACE14
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8271","JP_CHRIP:
-In a skin irritation test in which 0.1 mL of preparation including 73.1% of this substance was applied to rabbits for 4 hours or 1 hour, it was assessed as an irritant in a 4-hour application. (DFGMAK-Doc. 2 (1991)).
-On the other hand, in an occlusive test applied a solution of 500 to 1000 ppm in propylene glycol to 10 human volunteers for 24 hours, mild and visible redness of the skin shown in four persons and three persons reversed in 6 persons after 72 hours.
-Furthermore, the second application after 1 to 2 weeks reported that eight persons showed slightly severe dermal reactions (erythema and papules). (DFGMAK-Doc. 2 (1991))
-From the above test results on animals and humans, it was classified in Category 2.
-Besides, it is classified in R38 in EU classification.
-
-NZ_CCID:
-Skin Irritation
-SPECIES:
-RESULT: Commercial products containing BIT appears to have corrosive properties with risk of severe skin damage. However, in humans it appear that BlT is less potent when applied on the skin.
-REFERENCE SOURCE: Nordic Chemicals Group Health effects of selected chemicals 2. 1,2-Benzisothiazolin-3(2H)-one Nord PG:9-23 YR:1993 IP: VI:29 [toxline]
-NOTE: Skin irritant at 20% and above [ECB ANNEX1]
-Eye Irritation
-R PHRASE: R 41[IUCLID 2000]
-REMARK: Eye corrosive at 10% and above [ECB - ANNEX I]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,O=c1[nH]sc2ccccc12,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J7.640F,J-GLOBAL,O=c1[nH]sc2ccccc12,Train,1,2702,training
-"EU_REACH:
-diisotridecyl adipate (DITA)",,26401-35-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16101/7/4/2/?documentUUID=54019d71-740b-4d46-b8e7-37a7daf5c268,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCCCCCCOC(=O)CCCCC(=O)OCCCCCCCCCCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/94369,PubChem,CC(C)CCCCCCCCCCOC(=O)CCCCC(=O)OCCCCCCCCCCC(C)C,Train,1,2702,training
-"EU_REACH:
-1,3-dihydroxypropan-2-yl octanoate; 2,3-dihydroxypropyl octanoate",,26402-26-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17696/7/4/2/?documentUUID=4f689890-ff0b-4d7e-82c9-ecd3f4425f29,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCC(=O)OCC(CO)O,https://pubchem.ncbi.nlm.nih.gov/compound/3033877,PubChem,CCCCCCCC(=O)OCC(O)CO,Test,1,2702,training
-"AU_HCIS:
-[(tolyloxy)methyl]oxirane
-
-JP_CHRIP:
-1,2-Epoxy-3-(tolyloxy)propane
-
-NZ_CCID:
-Cresyl glycidyl ether","AU_HCIS:
-cresyl glycidyl ether
-Oxirane, [(methylphenoxy)methyl]-
-
-JP_CHRIP:
-2-[(Tolyloxy)methyl]oxirane",26447-14-3,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4532
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2077e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5F87AAB8-89DB-4CD7-BAED-C2EB78A1897B","JP_CHRIP:
-Based on descriptions that in a skin irritation test with rabbits, the Draize score was 5.2/8, and it was moderately irritating to the skin (PATTY (6th, 2012)), and that it is moderately to severely irritating to the skin in humans (HSDB (Access on June 2017)), it was classified in Category 2. Besides, this substance was classified as ""Skin Irrit. 2, H315"" in EU CLP classification (ECHA CL Inventory (Access on June 2017)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CC1=CC=C(C=C1)OCC2CO2,https://pubchem.ncbi.nlm.nih.gov/compound/16606,PubChem,Cc1ccc(OCC2CO2)cc1,Train,1,2702,training
-"EU_REACH:
-Di-2-thienylglycolic acid methyl ester",,26447-85-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6427/7/4/2/?documentUUID=913534b9-3b74-4574-b9db-10b23a736dea,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C(C1=CC=CS1)(C2=CC=CS2)O,https://pubchem.ncbi.nlm.nih.gov/compound/11414137,PubChem,COC(=O)C(O)(c1cccs1)c1cccs1,Train,1,2702,training
-"AU_HCIS:
-m-tolylidene diisocyanate
-
-KR_NCIS:
-Toluene diisocyanate
-
-NZ_CCID:
-Toluene diisocyanate","AU_HCIS:
-toluene-diisocyanate
-Benzene, 1,3-diisocyanatomethyl-
-
-KR_NCIS:
-1,3-Diisocyantomethylbenzene; Benzene, 1,3-diisocyanatomethyl; Benzene, 1,3-diisocyanatomethyl-; Diisocyanatotoluene; Hylene tlc; Isocyanic acid, methyl-m-phenylene ester; Methyl-m-phenylene isocyanate; Methylphenylene isocyanate; m-tolylidene diisocyanate; Toluene diisocyanate; Toluene diisocyanate (mixed isomers); Tolylene isocyanate
-
-NZ_CCID:
-1,3-Diisocyanatomethylbenzene, Benzene, 1,3-diisocyanatomethyl-, Isocyanic acid, methyl-m-phenylene ester, Methyl-m-phenylene isocyanate",26471-62-5,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4528
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C362D02C-524A-475D-B8C2-2E51E70D45CE","NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit / Guinea Pig
-RESULT: Medium irritant.
-REFERENCE SOURCE: (Zapp, 1957; Duprat et al., 1976). WHO; Environmental Health Criteria 75: Toluene Diisocyanates p. 33 (1987)[INCHEM]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Immediate reaction suggestive of pain, lachrymation, swelling of the eyelids, a conjunctival reaction, and mild damage to the cornea.
-REFERENCE SOURCE: (Zapp, 1957; Grant, 1974; Duprat et al., 1976; Woolrich, 1982). . WHO; Environmental Health Criteria 75: Toluene Diisocyanates p. 33 (1987)[INCHEM]",,"AU_HCIS, KR_NCIS, NZ_CCID",3,Cc1ccc(cc1N=C=O)N=C=O,https://cactus.nci.nih.gov/chemical/structure/26471-62-5/smiles,CACTUS,Cc1ccc(N=C=O)cc1N=C=O,Train,1,2702,training
-"EU_REACH:
-N-[(triethoxysilyl)methyl]cyclohexanamine",,26495-91-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24988/7/4/2/?documentUUID=8d55de31-6807-4e86-9df4-c460580e38b9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](CNC1CCCCC1)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/11818203,PubChem,CCO[Si](CNC1CCCCC1)(OCC)OCC,Train,1,2702,training
-"AU_HCIS:
-octhilinone (ISO)
-
-JP_CHRIP:
-2-n-Octyl-4-isothiazolin-3-one
-
-KR_NCIS:
-2-Octyl-3(2H)-isothiazolone
-
-NZ_CCID:
-Octhilinone
-
-US_HSDB:
-Octhilinone","AU_HCIS:
-2-octyl-2H-isothiazol-3-one
-3(2H)-Isothiazolone, 2-octyl-
-
-KR_NCIS:
-2-N-Octyl-4-Isothiazolin-3-One; 3(2H)-Isothiazolone, 2-Octyl-; 2-Octyl-2H-Isothiazol-3-One, Octhilinone
-
-NZ_CCID:
-2-Octyl-3-isothiazolone, 3(2H)-Isothiazolone, 2-octyl-, 2-n-Octyl-4-isothiazolin-3-one",26530-20-1,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3303
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0091e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D32A6E24-D388-4BA6-9D4D-5EFFE2F1182E
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/6713","JP_CHRIP:
-From severe erythema and edema accompanied by scab formation and tissue damage, a maximal score of 8.0, and ""corrosive"" classification in a test applied 0.5 mL of a 45 to 50% solution in propylene glycol to rabbit skins for 4 hours (DFGMAK-Doc. 16 (2001)), it was classified in Category 1.
-
-NZ_CCID:
-Skin Irritation
-SPECIES:
-RESULT: This compound is corrosive to tissues.
-REFERENCE SOURCE: (Rohm and Haas Company. Shipping Authorization for Skane HG. Spring House, PA. August 22, 1985.) [NTP]
-R-PHRASE: R 34 Causes burns. [NCLASS]
-Eye Irritation
-SPECIES:
-RESULT: Severe irritation
-REFERENCE SOURCE: (Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989. Vol. III, p. 2609, #OFE000.) [NTP]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,CCCCCCCCn1sccc1=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J10.439F,J-GLOBAL,CCCCCCCCn1sccc1=O,Train,1,2702,training
-"EU_REACH:
-2-chloro-N-methyl-N-(4-nitrophenyl)acetamide",,2653-16-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27267/7/4/2/?documentUUID=4d6cd41d-40cd-4853-aa24-c3c5839b0284,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C1=CC=C(C=C1)[N+](=O)[O-])C(=O)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/11436129,PubChem,CN(C(=O)CCl)c1ccc([N+](=O)[O-])cc1,Train,1,2702,training
-"EU_REACH:
-3-oxo-N-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)butanamide",,26576-46-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1884/7/4/2/?documentUUID=31160cee-a6ea-4a0f-b8f9-0b53b9d8d8f6,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)CC(=O)NC1=CC2=C(C=C1)NC(=O)N2,https://pubchem.ncbi.nlm.nih.gov/compound/117822,PubChem,CC(=O)CC(=O)Nc1ccc2[nH]c(=O)[nH]c2c1,Train,1,2702,training
-"AU_HCIS:
-1,3,5-Triazine-2,4,6(1H,3H,5H)-trione, 1,3,5-tris(3-isocyanatomethylphenyl)-",,26603-40-7,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4546,,,AU_HCIS,1,Cc1ccc(cc1N=C=O)N2C(=O)N(c3ccc(C)c(c3)N=C=O)C(=O)N(c4ccc(C)c(c4)N=C=O)C2=O,https://cactus.nci.nih.gov/chemical/structure/26603-40-7/smiles,CACTUS,Cc1ccc(-n2c(=O)n(-c3ccc(C)c(N=C=O)c3)c(=O)n(-c3ccc(C)c(N=C=O)c3)c2=O)cc1N=C=O,Train,1,2702,training
-"NZ_CCID:
-9-Octadecenamide, N,N-dimethyl-, (9Z)-",,2664-42-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/038DB0C6-F718-40CB-94A6-D90FEC238C10,,,NZ_CCID,1,CCCCCCCC/C=C\CCCCCCCC(=O)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/5356959,PubChem,CCCCCCCC/C=C\CCCCCCCC(=O)N(C)C,Train,1,2702,training
-"EU_REACH:
-N4-Benzoylcytosine",,26661-13-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22698/7/4/2/?documentUUID=1d4071e4-464a-4526-b4c6-49e80bcfc191,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C(=O)NC2=CC=NC(=O)N2,https://pubchem.ncbi.nlm.nih.gov/compound/309343,PubChem,O=C(Nc1ccnc(=O)[nH]1)c1ccccc1,Train,1,2702,training
-"KR_NCIS:
-2-Methoxy-4-(2-sulfatoethylsulfonyl)aniline",,26672-22-0,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,COC1=C(C=CC(=C1)S(=O)(=O)CCOS(=O)(=O)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/12116239,PubChem,COc1cc(S(=O)(=O)CCOS(=O)(=O)O)ccc1N,Train,1,2702,training
-"NZ_CCID:
-2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9-bis[2,4-bis(1,1-dimethylethyl)phenoxy]-",,26741-53-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5D443BC8-C4F4-4725-B908-53C735BF19C1,,,NZ_CCID,1,CC(C)(C)C1=CC(=C(C=C1)OP2OCC3(CO2)COP(OC3)OC4=C(C=C(C=C4)C(C)(C)C)C(C)(C)C)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/93101,PubChem,CC(C)(C)c1ccc(OP2OCC3(CO2)COP(Oc2ccc(C(C)(C)C)cc2C(C)(C)C)OC3)c(C(C)(C)C)c1,Train,1,2702,training
-"AU_HCIS:
-1,3-Diazetidine-2,4-dione, 1,3-bis(3-isocyanatomethylphenyl)-",,26747-90-0,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1205,,,AU_HCIS,1,Cc1ccc(cc1N=C=O)N2C(=O)N(c3ccc(C)c(c3)N=C=O)C2=O,https://cactus.nci.nih.gov/chemical/structure/26747-90-0/smiles,CACTUS,Cc1ccc(N2C(=O)N(c3ccc(C)c(N=C=O)c3)C2=O)cc1N=C=O,Train,1,2702,training
-"EU_REACH:
-tert-butyl 2,2,3,5-tetramethylhexaneperoxoate; tert-butyl 2,2-diethylhexaneperoxoate; tert-butyl 2,2-dimethyloctaneperoxoate; tert-butyl 2,4-dimethyl-2-(propan-2-yl)pentaneperoxoate; tert-butyl 2-ethyl-2,5-dimethylhexaneperoxoate",,26748-41-4,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13656/7/4/2/?documentUUID=cda40fb2-caed-4113-ab5a-fc854fa1b883,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)CCCCCC(=O)OOC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/117856,PubChem,CC(C)(C)CCCCCC(=O)OOC(C)(C)C,Train,1,2702,training
-"EU_REACH:
-1-methyl-1-phenylethyl 2-ethyl-2,5-dimethylhexaneperoxoate",,26748-47-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24271/7/4/2/?documentUUID=f4fd5ed7-6a0e-42fb-8d5e-14c91e7b1693,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)CCCCCC(=O)OOC(C)(C)c1ccccc1,https://cactus.nci.nih.gov/chemical/structure/26748-47-0/smiles,CACTUS,CC(C)(C)CCCCCC(=O)OOC(C)(C)c1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-Diisodecyl phthalate [DIDP]","JP_CHRIP:
-1,2-benzenedicarboxylic acid, diisodecyl ester
-bis(8-Methylnonyl) phthalate
-di-''isodecyl'' phthalate
-DIDP
-diisodecyl benzene-1,2-dicarboxylate",26761-40-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0127e.html,"JP_CHRIP:
-In a skin irritation test (OECD TG 404) using rabbits, transient very slight irritation was observed. Moreover, in other rabbit skin irritation tests (4-hour application), skin irritation was transient and very slight (EU-RAR (2003), DFGOT (2015)). Also, in a human patch test, when applying 0.2 mL occlusively for 24 hours to 15 subjects, irritation was not observed in the examinations at 30 minutes and 24 hours after patch removal (EU-RAR (2003)). Based on these results, it was judged to be classified as ""Not classified"" (Category 3 in UN GHS classification).",Provided,JP_CHRIP,1,CC(C)CCCCCCCOC(=O)c1ccccc1C(=O)OCCCCCCCC(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.799K,J-GLOBAL,CC(C)CCCCCCCOC(=O)c1ccccc1C(=O)OCCCCCCCC(C)C,Train,1,2702,training
-"EU_REACH:
-(oxiran-2-yl)methyl 2,2-dimethyloctanoate",,26761-45-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1888/7/4/2/?documentUUID=afeab056-6d26-470f-8075-09180e937b0b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)(CCC(C)C)C(=O)OCC1CO1,https://cactus.nci.nih.gov/chemical/structure/26761-45-5/smiles,CACTUS,CCC(C)(CCC(C)C)C(=O)OCC1CO1,Train,1,2702,training
-"AU_HCIS:
-Methylisothiazolone
-
-KR_NCIS:
-2-Methyl-4-isothiazolin-3-one
-
-NZ_CCID:
-2-Methyl-3(2H)-isothiazolone
-
-US_HSDB:
-Methylisothiazolinone","AU_HCIS:
-Isothiazolone, 2-methyl-
-3-Methylisothiazolone
-2- Methylisothiazol-3(2H)-one
-
-KR_NCIS:
-2-Methyl-2H-isothiazol-3-one
-
-NZ_CCID:
-2-Methyl-4-isothiazolin-3-one, 2-Methyl-2H-isothiazol-3-one, 3(2H)-Isothiazolone, 2-methyl-, MIT",2682-20-4,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4839
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6F0425B2-2E68-4A2A-B6DE-CE8AFC264576
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8200","NZ_CCID:
-Skin Irritation
-REMARK: The a.i. in Kathon 886 (usually containing 13 400 mg/l) and CG (usually containing 15 000 mg/l) were corrosive when tested undiluted. Aqueous dilutions of a.i. with concentrations of 560 mg/l were nonirritating; 2 800 mg/l was slightly to moderately irritating; 5 600 -17 000 mg/l were moderately to severely irritating; and > 28 000 mg/l were corrosive. 
-
-Skin Irritation produced by methylchloroisothiazolinone and methylisothiazolinone was concentration dependent. Undiluted a.i. in Kathon CG and 886 were severely irritating to rabbit skin.
-REFERENCE SOURCE: Nordic Chemicals Group Health effects of selected chemicals 2. Kathon and 5-chloro-2-methyl-4-isotihazolin-3-one and 2-methyl-isothiazolin-3-one Nord PG:75-104 YR:1993 IP: VI:29 [toxline]
-
-Eye Irritation
-REMARK: The a.i. in Kathon 886 (usually containing 13 400 mg/l) and CG (usually containing 15 000 mg/l) were corrosive when tested undiluted. Aqueous dilutions of a.i. with concentrations of 560 mg/l were nonirritating; 2 800 mg/l was slightly to moderately irritating; 5 600 -17 000 mg/l were moderately to severely irritating; and > 28 000 mg/l were corrosive. Under occlusive patches, aqueous dilutions of a.i. containing 560 mg/l were nonirritating; 2 800 mg/l was moderately irritating, 5 600 mg/l was severely irritating; and 56 000 mg/l was corrosive.
-REFERENCE SOURCE: Nordic Chemicals Group Health effects of selected chemicals 2. Kathon and 5-chloro-2-methyl-4-isotihazolin-3-one and 2-methyl-isothiazolin-3-one Nord PG:75-104 YR:1993 IP: VI:29 [toxline]",,"AU_HCIS, KR_NCIS, NZ_CCID, US_HSDB",4,CN1C(=O)C=CS1,https://pubchem.ncbi.nlm.nih.gov/compound/39800,PubChem,Cn1sccc1=O,Train,1,2702,training
-"EU_REACH:
-3-hydroxy-N-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-2-naphthamide",,26848-40-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21197/7/4/2/?documentUUID=6d6354c0-803f-4490-9ee9-224b54fcc1d1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C=C(C(=CC2=C1)C(=O)NC3=CC4=C(C=C3)NC(=O)N4)O,https://pubchem.ncbi.nlm.nih.gov/compound/117877,PubChem,O=C(Nc1ccc2[nH]c(=O)[nH]c2c1)c1cc2ccccc2cc1O,Train,1,2702,training
-"EU_REACH:
-3-{[bis(2-methylpropoxy)(sulfanylidene)-λ⁵-phosphanyl]sulfanyl}-2-methylpropanoic acid",,268567-32-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5213/7/4/2/?documentUUID=b91d561e-f87b-4c2f-acc7-97d955ac2ab1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)COP(=S)(OCC(C)C)SCC(C)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/57357853,PubChem,CC(C)COP(=S)(OCC(C)C)SCC(C)C(=O)O,Train,1,2702,training
-"EU_REACH:
-1-octylpyrrolidin-2-one
-
-NZ_CCID:
-2-Pyrrolidinone, 1-octyl-","NZ_CCID:
-1-Octyl-2-pyrrolidinone, 1-Octyl-2-pyrrolidone, N-Octylpyrrolidinone, N-Octylpyrrolidone",2687-94-7,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16946/7/4/2/?documentUUID=4c4715ab-7fdd-4370-9dc4-978ee3aa6663
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F1A97CC4-DFD5-4184-AD2C-00627D59974F","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-NZ_CCID:
-Skin Irritation
-R-PHRASE: R 34 Causes Burns. [ECB - Annex 1]
-Eye Irritation
-R-PHRASE: R 34 Causes Burns. [ECB - Annex 1]",Provided,"EU_REACH, NZ_CCID",2,CCCCCCCCN1CCCC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/3033871,PubChem,CCCCCCCCN1CCCC1=O,Train,1,2702,training
-"NZ_CCID:
-1-Dodecyl-2-pyrrolidone","NZ_CCID:
-2-Pyrrolidinone, 1-dodecyl-",2687-96-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4656290C-E345-4B58-A5F8-3CDDBAD82F2E,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 34 [N-CLASS]
-Eye Irritation
-R-PHRASE: R 34 Causes burns.",,NZ_CCID,1,CCCCCCCCCCCCN1CCCC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/62459,PubChem,CCCCCCCCCCCCN1CCCC1=O,Train,1,2702,training
-"JP_CHRIP:
-Isooctanol","JP_CHRIP:
-Isooctanol (mixed isomers)
-Isooctyl alcohol
-Methylheptyl alcohol (mixed isomers)",26952-21-6,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0033e.html,"JP_CHRIP:
-In tests with rabbits, there are reports on moderate irritation by a 4-hour semi-occlusive application (PATTY (5th, 2001)) and moderate irritation and local necrosis by a 24-hour occlusive application (ACGIH (2001)). And it is reported that an application of the undiluted test substance for 6 to 24 hours produced erythema and edema, and intracutaneous hemorrhages (in some animals), the erythema disappeared within 2-3 days, and the skin became dry and tanned, becoming tough and rigid after 7-10 days. Then, the leathery skin was sloughed (Netherlands assessment document (2003), corresponding to List 2). From the above, an occlusive or semi-occlusive application caused moderate irritation, and local necrosis occurred 4 to 24 hours after the application, but reversibility was observed. Therefore, it was classified in Category 2.",,JP_CHRIP,1,CC(C)CCCCCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J12.469I,J-GLOBAL,CC(C)CCCCCO,Train,1,2702,training
-"JP_CHRIP:
-2-Chlorobenzylidenemalononitrile","JP_CHRIP:
-(o-Chlorobenzal)malononitrile
-2-Chlorobenzylidene malononitrile
-2-Chlorobenzylidenemalononitrile
-[(2-Chlorophenyl)methylene]propanedinitrile
-[2-(Chlorophenyl)methylene]malononitrile
-beta,beta-Dicyano-o-chlorostyrene
-CS (riot control agent)
-Propanedinitrile, [(2-chlorophenyl)methylene]-",2698-41-1,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2003e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified in Category 1 from (1) - (3).
-
-[Evidence Data]
-(1) This substance is a strong irritant, direct exposure causes irritation of the mucous membranes, and also in humans, irritation by this substance is reported (US AEGL (2014)).
-(2) This substance is used as an incapacitating agent for riot control and causes intense skin and eye irritation in humans, and direct exposure produces eye irritation, lacrimation, conjunctivitis, and skin burning (ACGIH (7th, 2019), HSDB (Access on April 2020)).
-(3) It is severely irritating to the skin and eye (GESTIS (Access on April 2020)).
-
-[Reference Data, etc.]
-(4) In a skin corrosion test by reconstructed epidermis model (Episkin) (OECD TG 431), this substance (5%) was shown to be not corrosive, and in a test similar to OECD TG 439, it was proven to be an irritant (REACH registration dossier (Access on May 2020)).",,JP_CHRIP,1,Clc1ccccc1C=C(C#N)C#N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J14.332D,J-GLOBAL,N#CC(C#N)=Cc1ccccc1Cl,Train,1,2702,training
-"EU_REACH:
-N~3~-(2-hydroxyethyl)-beta-alaninamide",,27076-30-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11896/7/4/2/?documentUUID=c639439e-c835-4bd0-b0e3-77c6391bb267,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CNCCO)C(=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/117919,PubChem,NC(=O)CCNCCO,Train,1,2702,training
-"NZ_CCID:
-Bis(trifluoroacetoxy)iodobenzene",,2712-78-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B6733301-22BC-4751-A294-37DA256AE85A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)I(OC(=O)C(F)(F)F)OC(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/102317,PubChem,O=C(OI(OC(=O)C(F)(F)F)c1ccccc1)C(F)(F)F,Train,1,2702,training
-"NZ_CCID:
-3,5-Dimethylbenzyl bromide",,27129-86-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/199AB10F-75BA-48AB-8E2C-9E035A91221E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=CC(=CC(=C1)CBr)C,https://pubchem.ncbi.nlm.nih.gov/compound/141334,PubChem,Cc1cc(C)cc(CBr)c1,Train,1,2702,training
-"EU_REACH:
-1-[2-(benzoyloxy)propoxy]propan-2-yl benzoate; 1-{[1-(benzoyloxy)propan-2-yl]oxy}propan-2-yl benzoate; 2-{[1-(benzoyloxy)propan-2-yl]oxy}propyl benzoate",,27138-31-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13387/7/4/2/?documentUUID=66d89daf-d896-4d1e-aacc-251192399dc4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(COCC(C)OC(=O)C1=CC=CC=C1)OC(=O)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/101560,PubChem,CC(COCC(C)OC(=O)c1ccccc1)OC(=O)c1ccccc1,Train,1,2702,training
-"AU_HCIS:
-3,6,9,12,15-Pentaoxaheptadecan-1-ol, 17-(nonylphenoxy)-",,27177-01-1,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6668,,,AU_HCIS,1,CCCCCCCCCC1=CC=CC=C1OCCOCCOCCOCCOCCOCCO,https://pubchem.ncbi.nlm.nih.gov/compound/168665,PubChem,CCCCCCCCCc1ccccc1OCCOCCOCCOCCOCCOCCO,Train,1,2702,training
-"AU_HCIS:
-3,6,9,12,15,18,21-Heptaoxatricosan-1-ol, 23-(nonylphenoxy)-",,27177-05-5,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6669,,,AU_HCIS,1,CCCCCCCCCC1=CC=C(C=C1)OCCOCCOCCOCCOCCOCCOCCOCCO,https://pubchem.ncbi.nlm.nih.gov/compound/72384,PubChem,CCCCCCCCCc1ccc(OCCOCCOCCOCCOCCOCCOCCOCCO)cc1,Train,1,2702,training
-"AU_HCIS:
-3,6,9,12,15,18,21,24,27-Nonaoxanonacosan-1-ol, 29-(nonylphenoxy)-",,27177-08-8,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6670,,,AU_HCIS,1,CCCCCCCCCc1cccc(OCCCOCCOCCOCCOCCOCCOCCOCCOCCOCO)c1,https://cactus.nci.nih.gov/chemical/structure/27177-08-8/smiles,CACTUS,CCCCCCCCCc1cccc(OCCCOCCOCCOCCOCCOCCOCCOCCOCCOCO)c1,Train,1,2702,training
-"NZ_CCID:
-Cyclohexanecarboxylic acid chloride","NZ_CCID:
-cyclohexanecarbonyl chloride",2719-27-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7B2530CB-DBD7-4B83-8315-C1DFBB8A1613,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CCC(CC1)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/75938,PubChem,O=C(Cl)C1CCCCC1,Train,1,2702,training
-"AU_HCIS:
-Phenol, (1,1,3,3-tetramethylbutyl)-",,27193-28-8,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5806,,,AU_HCIS,1,CC(C)(C)CC(C)(C)C1=CC=CC=C1O,https://pubchem.ncbi.nlm.nih.gov/compound/62530,PubChem,CC(C)(C)CC(C)(C)c1ccccc1O,Train,1,2702,training
-"AU_HCIS:
-1,2-Benzenediol, (1,1-dimethylethyl)-",,27213-78-1,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6587,,,AU_HCIS,1,CC(C)(C)c1cccc(O)c1O,https://cactus.nci.nih.gov/chemical/structure/27213-78-1/smiles,CACTUS,CC(C)(C)c1cccc(O)c1O,Train,1,2702,training
-"JP_CHRIP:
-2-Ethylhexyl nitrate",,27247-96-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0043e.html,"JP_CHRIP:
-On the basis of the ""not irritating"" evaluation as a result of a test applied to rabbit skins for 4 hours (OECD TG 404, GLP), in which skin reactions were not observed until 24 hours after application and minimal to slight erythema observed at 1 or 2 animals in 48 to 124 hours disappeared after 148 hours (IUCLID (2000)), it was classified as ""Not classified.""",Provided,JP_CHRIP,1,CCCCC(CC)CO[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J154.004A,J-GLOBAL,CCCCC(CC)CO[N+](=O)[O-],Train,1,2702,training
-"EU_REACH:
-octadecane-1,12-diol",,2726-73-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17479/7/4/2/?documentUUID=d944d2a6-3f6d-4237-b628-227c7febb79c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCC(CCCCCCCCCCCO)O,https://pubchem.ncbi.nlm.nih.gov/compound/95421,PubChem,CCCCCCC(O)CCCCCCCCCCCO,Train,1,2702,training
-"EU_REACH:
-2-methyldodecan-1-ol",,27458-92-0,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2154/7/4/2/?documentUUID=82621844-2fd3-4f79-9d3a-f1901c1dcc0d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCCCCCCO,https://pubchem.ncbi.nlm.nih.gov/compound/33865,PubChem,CC(C)CCCCCCCCCCO,Train,1,2702,training
-"EU_REACH:
-2-methylheptadecan-1-ol",,27458-93-1,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5497/7/4/2/?documentUUID=73283029-57dd-4bd4-a073-4f932936a0f9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCCCCCCCCCCCO,https://pubchem.ncbi.nlm.nih.gov/compound/62825,PubChem,CC(C)CCCCCCCCCCCCCCCO,Test,1,2702,training
-"EU_CLP:
-dodecyldiphenyl phosphate",,27460-02-2,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCCCCCCCCCCCOP(=O)(OC1=CC=CC=C1)OC2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/117982,PubChem,CCCCCCCCCCCCOP(=O)(Oc1ccccc1)Oc1ccccc1,Test,1,2702,training
-"EU_REACH:
-1-[bis(4-fluorophenyl)methyl]piperazine",,27469-60-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23189/7/4/2/?documentUUID=ae5825be-f25e-444e-85a1-9a76aed7c663,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CN(CCN1)C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F,https://pubchem.ncbi.nlm.nih.gov/compound/152932,PubChem,Fc1ccc(C(c2ccc(F)cc2)N2CCNCC2)cc1,Train,1,2702,training
-"KR_NCIS:
-Trimethylsilyl trifluoromethanesulfonate
-
-NZ_CCID:
-Trimethylsilyl trifluoromethanesulphonate","NZ_CCID:
-trimethylsilyl trifluoromethanesulfonate",27607-77-8,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D968ACFF-3943-4C6C-BC7D-E00A448192F2","NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"KR_NCIS, NZ_CCID",2,C[Si](C)(C)OS(=O)(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/65367,PubChem,C[Si](C)(C)OS(=O)(=O)C(F)(F)F,Train,1,2702,training
-"KR_NCIS:
-1,6-Bis(2,3-epoxypropoxy)naphthalene",,27610-48-6,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C1C(O1)COC2=CC3=C(C=C2)C(=CC=C3)OCC4CO4,https://pubchem.ncbi.nlm.nih.gov/compound/4987597,PubChem,c1cc(OCC2CO2)c2ccc(OCC3CO3)cc2c1,Train,1,2702,training
-"EU_REACH:
-2-butyloctanoic acid",,27610-92-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20154/7/4/2/?documentUUID=12e432dc-139c-49bd-b8a6-13302ed55fea,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCC(CCCC)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/33970,PubChem,CCCCCCC(CCCC)C(=O)O,Train,1,2702,training
-"EU_REACH:
-1,3,5-tris(3,5-di-tert-butyl-4-hydroxybenzyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione",,27676-62-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14358/7/4/2/?documentUUID=e5aee7f1-8861-46e7-9f5b-df7d55108d01,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)CN2C(=O)N(C(=O)N(C2=O)CC3=CC(=C(C(=C3)C(C)(C)C)O)C(C)(C)C)CC4=CC(=C(C(=C4)C(C)(C)C)O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/93115,PubChem,CC(C)(C)c1cc(Cn2c(=O)n(Cc3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)c(=O)n(Cc3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)c2=O)cc(C(C)(C)C)c1O,Train,1,2702,training
-"EU_REACH:
-3-{4-[2-(4-{3-[(2-methylprop-2-enoyl)oxy]propoxy}phenyl)propan-2-yl]phenoxy}propyl 2-methylprop-2-enoate",,27689-12-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16429/7/4/2/?documentUUID=3f6dd2cd-5941-4875-b8c4-1fc813b23b90,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OCCCOC1=CC=C(C=C1)C(C)(C)C2=CC=C(C=C2)OCCCOC(=O)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/94384,PubChem,C=C(C)C(=O)OCCCOc1ccc(C(C)(C)c2ccc(OCCCOC(=O)C(=C)C)cc2)cc1,Train,1,2702,training
-"EU_REACH:
-1-benzyl-2-methylbenzene; 1-benzyl-3-methylbenzene; 1-benzyl-4-methylbenzene",,27776-01-8,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2131/7/4/2/?documentUUID=dfd75625-8ba5-4245-8b5e-6dd00db231d4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,Cc1ccccc1Cc2ccccc2,https://cactus.nci.nih.gov/chemical/structure/27776-01-8/smiles,CACTUS,Cc1ccccc1Cc1ccccc1,Train,1,2702,training
-"AU_HCIS:
-Benzene, 1,3-bis(1-isocyanato-1-methylethyl)-",,2778-42-9,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5455,,,AU_HCIS,1,CC(C)(C1=CC(=CC=C1)C(C)(C)N=C=O)N=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/17719,PubChem,CC(C)(N=C=O)c1cccc(C(C)(C)N=C=O)c1,Train,1,2702,training
-"KR_NCIS:
-Bis(diethylamino)silane",,27804-64-4,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCN(CC)[Si]N(CC)CC,https://pubchem.ncbi.nlm.nih.gov/compound/14908161,PubChem,CCN(CC)[Si]N(CC)CC,Train,1,2702,training
-"AU_HCIS:
-Ethanol, 2-(nonylphenoxy)-",,27986-36-3,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6671,,,AU_HCIS,1,CCCCCCCCCC1=CC=CC=C1OCCO,https://pubchem.ncbi.nlm.nih.gov/compound/171092,PubChem,CCCCCCCCCc1ccccc1OCCO,Train,1,2702,training
-"EU_REACH:
-bis(1-methylcyclohexyl) phthalate",,27987-25-3,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25787/7/4/2/?documentUUID=321cb526-89c5-4b20-9cc6-27f029f163f5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(CCCCC1)OC(=O)C2=CC=CC=C2C(=O)OC3(CCCCC3)C,https://pubchem.ncbi.nlm.nih.gov/compound/3034464,PubChem,CC1(OC(=O)c2ccccc2C(=O)OC2(C)CCCCC2)CCCCC1,Train,1,2702,training
-"JP_CHRIP:
-1-Hydroxyethane-1,1-diylbis(phosphonic acid)","JP_CHRIP:
-1-Hydroxyethane-1,1-diphosphonic acid; 1-Hydroxyethylidene-1,1-diphosphonic acid
-etidronic acid",2809-21-4,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0127e.html,"JP_CHRIP:
-It was classified in Category 1 because it is described that the pH of the saturated aqueous solution was < 2 (IUCLID (2000)). Besides, it is also reported that it was moderately irritating in a test with rabbits (HERA (2004)).",,JP_CHRIP,1,CC(O)(P(=O)(O)O)P(=O)(O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J7.915D,J-GLOBAL,CC(O)(P(=O)(O)O)P(=O)(O)O,Train,1,2702,training
-"EU_REACH:
-1-[(2-chloro-4-nitrophenyl)diazenyl]-2-naphthol",,2814-77-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13624/7/4/2/?documentUUID=f431b5f6-8b29-4b7c-a566-1840127568bb,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C=CC(=C2N=NC3=C(C=C(C=C3)[N+](=O)[O-])Cl)O,https://pubchem.ncbi.nlm.nih.gov/compound/17778,PubChem,O=[N+]([O-])c1ccc(N=Nc2c(O)ccc3ccccc23)c(Cl)c1,Train,1,2702,training
-"EU_REACH:
-2-[(1-amino-4-hydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)oxy]ethyl phenyl carbonate",,28173-59-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11449/7/4/2/?documentUUID=619d5a79-082b-406d-b88e-a79457211518,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)OC(=O)OCCOC2=C(C3=C(C(=C2)O)C(=O)C4=CC=CC=C4C3=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/119885,PubChem,Nc1c(OCCOC(=O)Oc2ccccc2)cc(O)c2c1C(=O)c1ccccc1C2=O,Train,1,2702,training
-"NZ_CCID:
-3-(Bromomethyl)-benzonitrile",,28188-41-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E3E8E4A2-D699-493B-8970-3581D06D310E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)C#N)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/97249,PubChem,N#Cc1cccc(CBr)c1,Train,1,2702,training
-"EU_REACH:
-Benzene, 1,1'-oxybis[methyl-",,28299-41-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10988/7/4/2/?documentUUID=0024652e-5a33-4c5c-8b46-55cca3524868,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,Cc1ccccc1Oc2ccccc2C,https://cactus.nci.nih.gov/chemical/structure/28299-41-4/smiles,CACTUS,Cc1ccccc1Oc1ccccc1C,Train,1,2702,training
-"NZ_CCID:
-Methyl (trans-4-oxo-2-pentenoate)",,2833-24-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BB5B8D3A-6596-4A11-931D-D4612BEFD775,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,CC(=O)/C=C/C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/5363720,PubChem,COC(=O)/C=C/C(C)=O,Train,1,2702,training
-"EU_REACH:
-4-aminobenzamide",,2835-68-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11042/7/4/2/?documentUUID=3a8ba9a4-0f9b-4283-8963-e22318708054,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1C(=O)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/76079,PubChem,NC(=O)c1ccc(N)cc1,Train,1,2702,training
-"EU_REACH:
-2-amino-5-chlorophenol",,28443-50-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12346/7/4/2/?documentUUID=2f1f4314-7845-4274-b589-bc5adcf52ec3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C=C1Cl)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/91591,PubChem,Nc1ccc(Cl)cc1O,Train,1,2702,training
-"EU_REACH:
-4-(4-((((4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)AMINO)CARBONYL)AMINO)PHENOXY)-N-METHYL-2-PYRIDINECARBOXAMIDE",,284461-73-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6884/7/4/2/?documentUUID=f6b8e03a-392f-48c3-af53-f6774fda4d2e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/216239,PubChem,CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)cc2)ccn1,Train,1,2702,training
-"EU_REACH:
-4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide",,284462-37-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8171/7/4/2/?documentUUID=0bfe352c-870b-4dcc-9434-1565250ea030,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)N,https://pubchem.ncbi.nlm.nih.gov/compound/16655129,PubChem,CNC(=O)c1cc(Oc2ccc(N)cc2)ccn1,Train,1,2702,training
-"AU_HCIS:
-3-aminomethyl-3,5,5-trimethylcyclohexylamine
-
-JP_CHRIP:
-3-aminomethyl-3,5,5-trimethylcyclohexylamine
-
-NZ_CCID:
-Isophoronediamine","AU_HCIS:
-Cyclohexanemethanamine, 5-amino-1,3,3-trimethyl-
-
-JP_CHRIP:
-1-amino-3-aminomethyl-3,3,5-trimethylcyclohexane
-3-(aminomethyl)-3,5,5-trimethylcyclohexylamine
-
-NZ_CCID:
-3-Aminomethyl-3,5,5-trimethylcyclohexylamine, 5-Amino-1,3,3-trimethylcyclohexanemethylamine, Cyclohexanemethanamine, 5-amino-1,3,3,-trimethyl-, Cyclohexanemethylamine, 5-amino-1,3,3-trimethyl-, Isophorone diamine",2855-13-2,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=206
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0060e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B7F04EB2-EC22-43E1-9106-B9B04051AE81","JP_CHRIP:
-In the tests using rabbits and rats, the substance induced edemas and caused irritation and inflammation (SIDS (accessed in July 2008). In addition, its pH is 11.6 (8.5g/L, 20degC). Based on the information, the substance was classified into Category 1. Repeated exposure resulted in severe effects with incrustation and necrosis, and the substance has been classified into R34 in the EU classification (EU-Annex (accessed in July 2008)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [N-CLASS]
-Eye Irritation
-R PHRASE: R 34 [N-CLASS]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CC1(C)CC(N)CC(C)(CN)C1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J68.532A,J-GLOBAL,CC1(C)CC(N)CC(C)(CN)C1,Train,1,2702,training
-"AU_HCIS:
-Oxirane, decyl-",,2855-19-8,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5457,,,AU_HCIS,1,CCCCCCCCCCC1CO1,https://pubchem.ncbi.nlm.nih.gov/compound/17858,PubChem,CCCCCCCCCCC1CO1,Train,1,2702,training
-"NZ_CCID:
-2-Chlorobenzyl cyanide",,2856-63-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1DCB94FF-2D7A-4B96-BEAC-D7EF0FD54612,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)CC#N)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/76112,PubChem,N#CCc1ccccc1Cl,Train,1,2702,training
-"KR_NCIS:
-Bromotrimethylsilane
-
-NZ_CCID:
-Bromotrimethylsilane","NZ_CCID:
-trimethylbromosilane",2857-97-8,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5EE3FDB4-B770-4158-95E5-0FE671E9F5FE","NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"KR_NCIS, NZ_CCID",2,C[Si](C)(C)Br,https://pubchem.ncbi.nlm.nih.gov/compound/76113,PubChem,C[Si](C)(C)Br,Train,1,2702,training
-"NZ_CCID:
-Epoxycyclohexane","NZ_CCID:
-cyclohexene oxide",286-20-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5B84221A-B604-4B4C-A7B0-CC782535B958,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CCC2C(C1)O2,https://pubchem.ncbi.nlm.nih.gov/compound/9246,PubChem,C1CCC2OC2C1,Train,1,2702,training
-"JP_CHRIP:
-2-(Dimethylamino)ethyl methacrylate
-
-NZ_CCID:
-2-Propenoic acid, 2-methyl-, 2-(dimethylamino)ethyl ester, (dimethylaminoethyl methacrylate)
-
-US_HSDB:
-N,N-DIMETHYLAMINOETHYL METHACRYLATE","JP_CHRIP:
-2-dimethylaminoethyl methacrylate
-Dimethylamino-ethylmethacrylate
-dimethylaminoethyl methacrylate
-Methacrylic acid, 2-(dimethylamino)ethyl ester
-N,N-Dimethylaminoethyl methacrylate
-
-NZ_CCID:
-Dimethylaminoethylmethacrylate",2867-47-2,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/07-meti-2030e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/17929F50-404B-4284-B8CB-700FAB5633AB
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/5464","JP_CHRIP:
-It is classified as ""Category 1A-1C""in the three-ministry GHS division. Since UN GHS Document 3.2.2.4.2 says, ""For those authorities wanting more than one designation for corrosion, up to three sub-categories are provided within the corrosive category."" subdividing is not essential. It is therefore preferable to modify ""Category 1A-1C"" to ""Category 1"" from the view point of text representation as well.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Corrosive
-REFERENCE SOURCE: Atochem Paris la Defense (33) Report Consultox Laboratories Ltd. CL80 65 2030 (May 1980). [IUCLID 2000]
-REMARK: EC Classification: Corrosive (causes burns)
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Corrosive
-REFERENCE SOURCE: Atochem Paris la Defense
-(33) Report Consultox Laboratories Ltd. CL80 65 2030 (May 1980). [IUCLID 2000]
-REMARK: EC Classification: Irritating",,"JP_CHRIP, NZ_CCID, US_HSDB",3,CN(C)CCOC(=O)C(=C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J48.651E,J-GLOBAL,C=C(C)C(=O)OCCN(C)C,Train,1,2702,training
-"NZ_CCID:
-2,5-Furandione, dihydro-3-(octadecenyl)-",,28777-98-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/773A3D06-24AB-45BC-A0DB-57427ACD3B33,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,CCCCCCCCCCCCCCCC/C=C/C1CC(=O)OC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/5354626,PubChem,CCCCCCCCCCCCCCCC/C=C/C1CC(=O)OC1=O,Train,1,2702,training
-"JP_CHRIP:
-Cyclopentane","JP_CHRIP:
-Pentamethylene",287-92-3,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2044e.html,"JP_CHRIP:
-In a skin irritation test (OECD TG 404) with rabbits, no skin reaction (irritation score: 0.0) was observed, and it was determined that it was not irritating (SIDS (2010)). In addition, in a test with guinea pigs, there is a report that slight erythema was observed (Patty (2012), SIDS (2010)).
-From the above results, it was judged to be ""Not classified"" (Category 3 in UN GHS classification). Since the information described in the previous classification was absent from the Lists in the GHS classification guidance for the Japanese government, it was deleted, and test information according to any test guidelines was added, and the category was changed.",Provided,JP_CHRIP,1,C1CCCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.564J,J-GLOBAL,C1CCCC1,Train,1,2702,training
-"NZ_CCID:
-1-Octadecanethiol","NZ_CCID:
-n-octadecyl mercaptan",2885-00-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EF53F7A9-1BC2-4577-B223-3DC105C6BB3C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCCCCCCCCCCCCCCCCCS,https://pubchem.ncbi.nlm.nih.gov/compound/17905,PubChem,CCCCCCCCCCCCCCCCCCS,Train,1,2702,training
-"NZ_CCID:
-(9-Fluorenylmethyl) chloroformate",,28920-43-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4EC8D1DC-70AD-43BB-9828-8122F0EADF8B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/34367,PubChem,O=C(Cl)OCC1c2ccccc2-c2ccccc21,Train,1,2702,training
-"EU_REACH:
-1-(3-Chloro-4-hydroxyphenyl)ethanone",,2892-29-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17987/7/4/2/?documentUUID=3afdc14c-4f21-427b-a104-5a7b59735234,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C1=CC(=C(C=C1)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/1051514,PubChem,CC(=O)c1ccc(O)c(Cl)c1,Test,1,2702,training
-"EU_REACH:
-diethoxy(methyl){3-[(oxiran-2-yl)methoxy]propyl}silane",,2897-60-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17529/7/4/2/?documentUUID=bb5fc246-986c-4791-b454-b251d0cc1ef9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](C)(CCCOCC1CO1)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/62467,PubChem,CCO[Si](C)(CCCOCC1CO1)OCC,Train,1,2702,training
-"AU_HCIS:
-Phenol, 2-isononyl-4-methyl-",,28983-26-8,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6710,,,AU_HCIS,1,CC1=CC(=C(C=C1)O)CCCCCCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/120111,PubChem,Cc1ccc(O)c(CCCCCCC(C)C)c1,Train,1,2702,training
-"EU_REACH:
-α,α-Dimethyl-ethyl ester benzeneacetic acid",,2901-13-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12374/7/4/2/?documentUUID=38ea4503-bc60-4716-8d18-f21b8ff4b12d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C(C)(C)C1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/232036,PubChem,CCOC(=O)C(C)(C)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-3,5-Dichlorobenzoyl chloride",,2905-62-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F29E76C4-E04A-4C76-A6AD-6B66EA348FF8,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=C(C=C(C=C1Cl)Cl)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/76191,PubChem,O=C(Cl)c1cc(Cl)cc(Cl)c1,Train,1,2702,training
-"EU_REACH:
-3-(propan-2-yloxy)propan-1-amine",,2906-12-9,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21379/7/4/2/?documentUUID=6a0557df-4947-4c14-8d22-c9f9b4018e9a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)OCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/76194,PubChem,CC(C)OCCCN,Train,1,2702,training
-"EU_REACH:
-1-(2-hydroxy-2-methylpropoxy)-2,2,6,6-tetramethylpiperidin-4-yl octadecanoate",,290822-07-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12417/7/4/2/?documentUUID=54cbbb6a-12a6-448b-b961-6271e8cdbdf4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCCC(=O)OC1CC(N(C(C1)(C)C)OCC(C)(C)O)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/21885088,PubChem,CCCCCCCCCCCCCCCCCC(=O)OC1CC(C)(C)N(OCC(C)(C)O)C(C)(C)C1,Train,1,2702,training
-"EU_REACH:
-2,4-dichloro-1,3-dinitro-5-(trifluoromethyl)benzene",,29091-09-6,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12251/7/4/2/?documentUUID=7bbc6ef0-1cce-44cb-b0b9-480739d9b09c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(C(=C(C(=C1[N+](=O)[O-])Cl)[N+](=O)[O-])Cl)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/94398,PubChem,O=[N+]([O-])c1cc(C(F)(F)F)c(Cl)c([N+](=O)[O-])c1Cl,Test,1,2702,training
-"NZ_CCID:
-Chlorophenylacetyl chloride",,2912-62-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/830B5AA4-2870-4EE0-A1C2-F6B191269F9C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)C(C(=O)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/102902,PubChem,O=C(Cl)C(Cl)c1ccccc1,Train,1,2702,training
-"EU_REACH:
-biphenyl-4-carbonitrile",,2920-38-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20254/7/4/2/?documentUUID=fe7bbedb-9335-4fce-8d7c-4c7a24ad4b8b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C2=CC=C(C=C2)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/18021,PubChem,N#Cc1ccc(-c2ccccc2)cc1,Train,1,2702,training
-"JP_CHRIP:
-O-2-(Diethylamino)-6-methylpyrimidin-4-yl O,O-dimethyl phosphorothioate (synonym: Pirimiphos-methy)","JP_CHRIP:
-Phosphorothioic acid, O-[2-(diethylamino)-6-methyl-4-pyrimidinyl] O,O-dimethyl ester
-Pirimiphos-methyl
-Pyrimiphos-methyl",29232-93-7,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2019.html,"JP_CHRIP:
-【分類根拠】
-（１）より、ガイダンスに従い、区分2とした。なお、新たな知見に基づき、分類結果を変更した。
-
-【根拠データ】
-（１）本物質は中程度の刺激性物質である（EPA Pesticies (2006)）。
-
-【参考データ等】
-（２）ウサギを用いた皮膚刺激性試験において、軽度の刺激性がみられたとの報告がある（HSDB (Accessed Aug. 2021)）。
-（３）本物質は軽度の刺激性物質である（EFSA (2005)）。",,JP_CHRIP,1,CCN(CC)c1nc(C)cc(OP(=S)(OC)OC)n1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.487H,J-GLOBAL,CCN(CC)c1nc(C)cc(OP(=S)(OC)OC)n1,Train,1,2702,training
-"JP_CHRIP:
-Allyl chloroformate",,2937-50-0,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0138e.html,"JP_CHRIP:
-The substance was classified as Category 2 based on the documented case of ""skin irritation"" in rabbit test (HSDB (2003)). As relevant notes, contact with the undiluted substance caused irritation to human skin. The substance was fairly severe irritant and may cause pain and burns of second-degree after a few minutes of contact (HSDB (2003)).",,JP_CHRIP,1,ClC(=O)OCC=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J26.248J,J-GLOBAL,C=CCOC(=O)Cl,Train,1,2702,training
-"NZ_CCID:
-Triethoxyoctylsilane","NZ_CCID:
-octyltriethoxysilane",2943-75-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2E98C8C6-518C-424F-B104-D643220B3B43,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CCCCCCCC[Si](OCC)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/76262,PubChem,CCCCCCCC[Si](OCC)(OCC)OCC,Train,1,2702,training
-"EU_CLP:
-1,4,7,10-tetraazacyclododecane",,294-90-6,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1CNCCNCCNCCN1,https://pubchem.ncbi.nlm.nih.gov/compound/64963,PubChem,C1CNCCNCCNCCN1,Test,1,2702,training
-"NZ_CCID:
-1,4,8,11-Tetraazacyclotetradecane",,295-37-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/ECC3E2D7-D240-4F5F-813B-E7378F8A25C8,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1CNCCNCCCNCCNC1,https://pubchem.ncbi.nlm.nih.gov/compound/64964,PubChem,C1CNCCNCCCNCCNC1,Train,1,2702,training
-"EU_REACH:
-1,4-bis[(2-ethylhexyl)amino]-5,8-dihydroxy-9,10-dihydroanthracene-9,10-dione",,295800-70-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29374/7/4/2/?documentUUID=97077ee6-b7fc-4b8e-8557-b160b8eb7744,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)CNC1=C2C(=C(C=C1)NCC(CC)CCCC)C(=O)C3=C(C=CC(=C3C2=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/23062166,PubChem,CCCCC(CC)CNc1ccc(NCC(CC)CCCC)c2c1C(=O)c1c(O)ccc(O)c1C2=O,Test,1,2702,training
-"NZ_CCID:
-Isooctyl acrylate",,29590-42-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C3F73773-8AEB-43B5-A568-D863EA859C9A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]
-Eye Irritation
-R PHRASE: R 36 [ECB]",,NZ_CCID,1,CC(C)CCCCCOC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/165746,PubChem,C=CC(=O)OCCCCCC(C)C,Train,1,2702,training
-"EU_REACH:
-2-bromo-5-hydroxy-4-methoxybenzaldehyde",,2973-59-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24229/7/4/2/?documentUUID=2ca6ec2b-52ae-4003-a639-9d611275a500,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=C(C=C(C(=C1)Br)C=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/616068,PubChem,COc1cc(Br)c(C=O)cc1O,Train,1,2702,training
-"EU_REACH:
-3-ethoxy-1,1,1,2,3,4,4,5,5,6,6,6-dodecafluoro-2-(trifluoromethyl)hexane",,297730-93-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21902/7/4/2/?documentUUID=83180d8a-21f8-4490-b100-1b6ff5dd48eb,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(C(C(F)(F)F)(C(F)(F)F)F)(C(C(C(F)(F)F)(F)F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/2782436,PubChem,CCOC(F)(C(F)(F)C(F)(F)C(F)(F)F)C(F)(C(F)(F)F)C(F)(F)F,Train,1,2702,training
-"JP_CHRIP:
-Dimethyl-p-nitrophenylthiophosphate; Methylparathion","JP_CHRIP:
-Dimethyl-p-nitrophenylthiophosphate
-Methyl parathion
-Methylparathion
-O,O-Dimethyl O-4-nitrophenyl phosphorothioate
-O,O-Dimethyl-p-nitrophenylthionophosphate
-Parathion-methyl
-Phosphorothioic acid, O,O-dimethyl O-(4-nitrophenyl) ester",298-00-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2046e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified as ""Not classified"" from (1) - (6). The classification result was changed due to new data obtained.
-
-[Evidence Data]
-(1) This substance (technical grade) did not irritate the skin and eye (EHC 145 (1993)).
-(2) As a result of 4-hour or 6-hour application of this substance to the rabbit skin at up to the lethal dose (LD100), no irritation was shown (EHC 145 (1993)).
-(3) It was not irritating in a skin irritation test with rabbits according to OECD TG 404 (EHC 145 (1993)).
-(4) It was slightly irritating to the skin in rabbits (JMPR (1995)).
-(5) In a skin irritation test with rabbits according to EPA OPPTS 870.2500, the maximum score was 2, and the score after 72 hours was 0.5 (EPA Pesticides (2006)).
-(6) This substance is not irritating to the skin and eye (GESTIS (Access on May 2020)).
-
-[Reference Data, etc.]
-(7) In a skin irritation test by 1 to 24-hour semi-occlusive application of a formulation containing 80% of this substance to the rabbit skin, very minor to moderate reddening was seen at 1 hour after the application (GESTIS (Access on May 2020)).",Provided,JP_CHRIP,1,COP(=S)(OC)Oc1ccc(cc1)[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.981E,J-GLOBAL,COP(=S)(OC)Oc1ccc([N+](=O)[O-])cc1,Train,1,2702,training
-"JP_CHRIP:
-O,O-Diethyl-S-(2-ethylthioethyl) dithiophosphate [Disulfoton]","JP_CHRIP:
-Dithiodemeton
-O,O-Diethyl S-(2-ethylmercaptoethyl) dithiophosphate
-O,O-Diethyl S-2-(ethylthio)ethyl phosphorodithioate
-O,O-Diethyl-S-(2-ethylthioethyl) dithiophosphate
-Phosphorodithioic acid, O,O-diethyl S-[2-(ethylthio)ethyl] ester",298-04-4,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2075e.html,"JP_CHRIP:
-Based on the descriptions that it is severely irritating to human skin (EPA Pesticide (2006), HSDB (Access on June 2017)), it was classified in Category 2. The category was revised based on the information obtained in this research.",,JP_CHRIP,1,CCOP(=S)(OCC)SCCSCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.982C,J-GLOBAL,CCOP(=S)(OCC)SCCSCC,Train,1,2702,training
-"EU_REACH:
-O,O-diethyl sulfanylphosphonothioate",,298-06-6,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11749/7/4/2/?documentUUID=6e4adc46-cfc4-4263-bfcb-f7ecd7d659f6,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOP(=S)(OCC)S,https://pubchem.ncbi.nlm.nih.gov/compound/9274,PubChem,CCOP(=S)(S)OCC,Test,1,2702,training
-"JP_CHRIP:
-Bis(2-ethylhexyl) hydrogen phosphate
-
-NZ_CCID:
-Di(2-ethylhexyl)phosphate","JP_CHRIP:
-bis(2-ethylhexyl) hydrogen phosphate
-Bis(2-ethylhexyl)hydrogen phosphate
-Bis(2-ethylhexyl)orthophosphoric acid
-Bis(isooctyl)phosphate
-di(2-ethylhexyl) phosphate
-Di(2-ethylhexyl)phosphate
-Dioctylphosphate",298-07-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0092e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8EAD103D-96BC-4C0B-93B6-6439F764973D","JP_CHRIP:
-It was classified in Category 1 because it was corrosive in a skin irritation test in which 0.5 mL of this substance was applied to rabbits for 1-8 hours (USEPA/HPV (2001)), it was highly irritating and the primary dermal irritation index (PDII) was 6.2 in another test by a 24-hour occlusive application of 0.5 mL of undiluted this substance to rabbits (HPVIS (2009)). Besides, in tests with rabbits other than the above tests, it is also reported that PDII was 0, and it was not irritating after a 24-hour occlusive application of 0.5 mL, and PDII was 4.85, it was irritating but not corrosive after a 48-hour occlusive application (HPVIS (2009)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CCCCC(CC)COP(=O)(O)OCC(CC)CCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.641A,J-GLOBAL,CCCCC(CC)COP(=O)(O)OCC(CC)CCCC,Train,1,2702,training
-"EU_REACH:
-2-oxoacetic acid",,298-12-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14954/7/4/2/?documentUUID=b493d280-8df0-48d5-90dd-bce397a1446f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(=O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/760,PubChem,O=CC(=O)O,Train,1,2702,training
-"AU_HCIS:
-Oxetane, 3-ethyl-3-[[(2-ethylhexyl)oxy]methyl]-",,298695-60-0,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3324,,,AU_HCIS,1,CCCCC(CC)COCC1(COC1)CC,https://pubchem.ncbi.nlm.nih.gov/compound/21867834,PubChem,CCCCC(CC)COCC1(CC)COC1,Train,1,2702,training
-"EU_REACH:
-1-(2-butoxy-1-methylethoxy)propan-2-ol
-
-JP_CHRIP:
-Dipropylene glycol butyl ether","JP_CHRIP:
-Dipropylene glycol-n-butyl ether
-DPGnBE
-n-Butoxy-methylethoxy-propanol
-n-Butoxy-propoxy-propanol",29911-28-2,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14152/7/4/2/?documentUUID=d89cf177-0f95-4fe4-9134-27c9c0f7e0aa
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-0006e.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-It was classified as ""Not classified"" because there was no irritation in a skin irritation test with rabbits (SIDS (2005)).",Provided,"EU_REACH, JP_CHRIP",2,CCCCOCC(C)OCC(C)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J50.956F,J-GLOBAL,CCCCOCC(C)OCC(C)O,Train,1,2702,training
-"EU_REACH:
-dimethyl 5-({2-oxo-1-[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)carbamoyl]propyl}diazenyl)isophthalate",,29920-31-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10984/7/4/2/?documentUUID=28f34200-1e34-4186-b472-1631620184b7,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC2=C(C=C1)NC(=O)N2)N=NC3=CC(=CC(=C3)C(=O)OC)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/121754,PubChem,COC(=O)c1cc(N=NC(C(C)=O)C(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)cc(C(=O)OC)c1,Train,1,2702,training
-"EU_REACH:
-ethyl 4-oxopiperidine-1-carboxylate",,29976-53-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21330/7/4/2/?documentUUID=2aadac35-b431-48c7-ad3e-46c81adc2b8b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)N1CCC(=O)CC1,https://pubchem.ncbi.nlm.nih.gov/compound/34767,PubChem,CCOC(=O)N1CCC(=O)CC1,Train,1,2702,training
-"AU_HCIS:
-Phenol, dioctyl-",,29988-16-7,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5807,,,AU_HCIS,1,CCCCCCCCC1=C(C(=CC=C1)O)CCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/121608,PubChem,CCCCCCCCc1cccc(O)c1CCCCCCCC,Train,1,2702,training
-"NZ_CCID:
-Tetrahydrofurfuryl chloride",,3003-84-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CFD2476A-1A23-404E-897A-B160EF1A536A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1CC(OC1)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/18150,PubChem,ClCC1CCCO1,Train,1,2702,training
-"NZ_CCID:
-N,N-Dimethyldodecanamide","NZ_CCID:
-Dodecanamide, N,N-dimethyl-",3007-53-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/33B022C3-FE19-479C-86B2-1D2AF6469797,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCCCCCCCC(=O)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/18159,PubChem,CCCCCCCCCCCC(=O)N(C)C,Train,1,2702,training
-"JP_CHRIP:
-naled
-
-KR_NCIS:
-Naled
-
-US_HSDB:
-NALED","JP_CHRIP:
-1,2-Dibromo-2,2-dichloroethyl dimethyl phosphate
-Phosphoric acid, 1,2-dibromo-2,2-dichloroethyl dimethyl ester
-
-KR_NCIS:
-Dimethyl 1,2-dibromo-2,2-dichloroethyl phosphate; 1,2-Dibromo-2,2-dichloroethyl dimethyl phosphate",300-76-5,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0075e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1148","JP_CHRIP:
-Since ACGIH (2002) describes that severe skin irritations was observed on rabbits and that dermatitis was observed in human exposure case, it was classified as Category 2.",,"JP_CHRIP, KR_NCIS, US_HSDB",3,COP(=O)(OC)OC(Br)C(Cl)(Cl)Br,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.276J,J-GLOBAL,COP(=O)(OC)OC(Br)C(Cl)(Cl)Br,Train,1,2702,training
-"NZ_CCID:
-3-Hydroxybutyric acid",,300-85-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CA25911F-46FA-4837-A2A2-324125EBDB30,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(CC(=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/441,PubChem,CC(O)CC(=O)O,Train,1,2702,training
-"JP_CHRIP:
-Oleamide","JP_CHRIP:
-(9Z)-9-Octadecenamide
-cis-9-Octadecenamide
-Oleamide
-oleamide (synonym:oleic acid amide)
-oleic acid amide
-Oleylamide",301-02-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0144e.html,"JP_CHRIP:
-In the rabbit test (OECD TG404), the result of ""not irritating"" was reported (IUCLID (2000)). In other rabbit test (GLP-compliant), 4-hour application of undiluted substance caused no irritation (IUCLID (2000)). Based on these documents, the substance was classified as ""Not classified"".",Provided,JP_CHRIP,1,CCCCCCCC/C=C\CCCCCCCC(=O)N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J36.613G,J-GLOBAL,CCCCCCCC/C=C\CCCCCCCC(N)=O,Train,1,2702,training
-"AU_HCIS:
-Phenol, 2-methyl-4,6-dinonyl-",,3011-61-8,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5791,,,AU_HCIS,1,CCCCCCCCCC1=CC(=C(C(=C1)C)O)CCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/76383,PubChem,CCCCCCCCCc1cc(C)c(O)c(CCCCCCCCC)c1,Train,1,2702,training
-"NZ_CCID:
-Trichloroacetyl isocyanate",,3019-71-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1434690D-7856-4613-9A7D-3B1964E07968,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(=NC(=O)C(Cl)(Cl)Cl)=O,https://pubchem.ncbi.nlm.nih.gov/compound/76400,PubChem,O=C=NC(=O)C(Cl)(Cl)Cl,Train,1,2702,training
-"EU_REACH:
-hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate",,302776-68-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29413/7/4/2/?documentUUID=83541961-9212-4e36-b089-f60da40f54d0,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCOC(=O)C1=CC=CC=C1C(=O)C2=C(C=C(C=C2)N(CC)CC)O,https://pubchem.ncbi.nlm.nih.gov/compound/10111431,PubChem,CCCCCCOC(=O)c1ccccc1C(=O)c1ccc(N(CC)CC)cc1O,Train,1,2702,training
-"NZ_CCID:
-1,2-Ethanediamine, N-[2-(dimethylamino)ethyl]-N,N',N'-trimethyl-","NZ_CCID:
-1,1,4,7,7-Pentamethyldiethylenetriamine, Diethylenetriamine, 1,1,4,7,7-pentamethyl-, PMDT, Pentamethyldiethylenetriamine",3030-47-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1DE3FF7D-8DD3-4413-906B-A0FAE0DACC7C,,,NZ_CCID,1,CN(C)CCN(C)CCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/18196,PubChem,CN(C)CCN(C)CCN(C)C,Train,1,2702,training
-"EU_REACH:
-4-{4-[difluoro(3,4,5-trifluorophenoxy)methyl]-3,5-difluorophenyl}-3-fluoro-4'-propyl-1,1'-biphenyl",,303186-36-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24181/7/4/2/?documentUUID=da8c4a98-d7fe-45c0-80be-257d4a8c4ea3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1=CC=C(C=C1)C2=CC(=C(C=C2)C3=CC(=C(C(=C3)F)C(OC4=CC(=C(C(=C4)F)F)F)(F)F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/59856380,PubChem,CCCc1ccc(-c2ccc(-c3cc(F)c(C(F)(F)Oc4cc(F)c(F)c(F)c4)c(F)c3)c(F)c2)cc1,Train,1,2702,training
-"EU_REACH:
-{2-[2-(dimethylamino)ethoxy]ethyl}dimethylamine
-
-JP_CHRIP:
-Ethanamine, 2,2'-oxybis[N,N-dimethyl-
-
-NZ_CCID:
-Bis(2-(dimethylamino)ethyl) ether","JP_CHRIP:
-Bis(2-dimethylaminoethyl) ether
-N,N,N',N'-Tetramethyl-2,2'-oxybis(ethylamine)
-
-NZ_CCID:
-Bis(2-dimethylaminoethyl) ether, Bis(2-dimethylaminoethyl)ether",3033-62-3,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13873/7/4/2/?documentUUID=eb184b71-37c0-4bd2-b79c-433ffc676e4d
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0894e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/972B920A-FDFC-4E5E-94CD-66DD334413C9","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-From description that necrosis was accepted by the test applied to the rabbit skin (ACGIH (7th, 2001)), it was judged that there was caustic, and it was set as Category 1A-1C.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,CN(C)CCOCCN(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J12.980A,J-GLOBAL,CN(C)CCOCCN(C)C,Train,1,2702,training
-"EU_REACH:
-2-methylheptadecanoic acid",,30399-84-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13713/7/4/2/?documentUUID=c2d776d1-1afe-454e-9f6f-1e1489ddb675,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCCCCCCCCCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/21859,PubChem,CC(C)CCCCCCCCCCCCCCC(=O)O,Train,1,2702,training
-"EU_REACH:
-ethyl 2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]benzoate",,304435-84-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19791/7/4/2/?documentUUID=ca4a442b-e4ad-4b32-bd57-af081c821a9c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=C(C=C(C=C1)S(=O)(=O)N2CCN(CC2)C)C(=O)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/22052241,PubChem,CCOC(=O)c1cc(S(=O)(=O)N2CCN(C)CC2)ccc1OCC,Train,1,2702,training
-"EU_REACH:
-p-[(5-cyano-1,6-dihydro-2-hydroxy-1,4-dimethyl-6-oxo-3-pyridyl)azo]-N-(2-ethylhexyl)benzamide",,30449-81-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21061/7/4/2/?documentUUID=3ddd1ff1-26bb-49e8-8fa4-2d194fa1fff9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)CNC(=O)C1=CC=C(C=C1)N=NC2=C(C(=C(N(C2=O)C)O)C#N)C,https://pubchem.ncbi.nlm.nih.gov/compound/121713,PubChem,CCCCC(CC)CNC(=O)c1ccc(N=Nc2c(C)c(C#N)c(O)n(C)c2=O)cc1,Train,1,2702,training
-"AU_HCIS:
-Ethanol, 2-[2-(dodecyloxy)ethoxy]-",,3055-93-4,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6492,,,AU_HCIS,1,CCCCCCCCCCCCOCCOCCO,https://pubchem.ncbi.nlm.nih.gov/compound/76457,PubChem,CCCCCCCCCCCCOCCOCCO,Train,1,2702,training
-"AU_HCIS:
-Ethanol, 2-[2-[2-(dodecyloxy)ethoxy]ethoxy]-",,3055-94-5,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6493,,,AU_HCIS,1,CCCCCCCCCCCCOCCOCCOCCO,https://pubchem.ncbi.nlm.nih.gov/compound/76458,PubChem,CCCCCCCCCCCCOCCOCCOCCO,Train,1,2702,training
-"AU_HCIS:
-3,6,9,12,15-Pentaoxaheptacosan-1-ol",,3055-95-6,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6494,,,AU_HCIS,1,CCCCCCCCCCCCOCCOCCOCCOCCOCCO,https://pubchem.ncbi.nlm.nih.gov/compound/18281,PubChem,CCCCCCCCCCCCOCCOCCOCCOCCOCCO,Train,1,2702,training
-"AU_HCIS:
-3,6,9,12,15,18,21-Heptaoxatritriacontan-1-ol",,3055-97-8,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6495,,,AU_HCIS,1,CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCO,https://pubchem.ncbi.nlm.nih.gov/compound/76459,PubChem,CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCO,Train,1,2702,training
-"EU_CLP:
-cyclohexyl acrylate",,3066-71-5,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C=CC(=O)OC1CCCCC1,https://pubchem.ncbi.nlm.nih.gov/compound/18298,PubChem,C=CC(=O)OC1CCCCC1,Test,1,2702,training
-"JP_CHRIP:
-4-methyloxetan-2-one; (+/-)-4-methyloxetan-2-one","JP_CHRIP:
-.beta.-Butyrolactone
-beta-Butyrolactone",3068-88-0,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0933e.html,"JP_CHRIP:
-It was set as Category 2 from description that the moderate irritation was acknowledged by application on the skin of the rabbit (RTECS (2005)).",,JP_CHRIP,1,CC1CC(=O)O1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J10.579A,J-GLOBAL,CC1CC(=O)O1,Train,1,2702,training
-"EU_REACH:
-(2-aminoethyl)[3-(methoxydimethylsilyl)propyl]amine",,3069-33-8,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17243/7/4/2/?documentUUID=550955f7-5c32-4129-a3b9-cadf21911fe6,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CO[Si](C)(C)CCCNCCN,https://pubchem.ncbi.nlm.nih.gov/compound/76484,PubChem,CO[Si](C)(C)CCCNCCN,Test,1,2702,training
-"US_HSDB:
-Perfluorohexanoic acid",,307-24-4,Cat 1,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8299,,,US_HSDB,1,C(=O)(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)O,https://pubchem.ncbi.nlm.nih.gov/compound/67542,PubChem,O=C(O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train,1,2702,training
-"EU_REACH:
-2-{[2,6-dibromo-4-(2-{3,5-dibromo-4-[(oxiran-2-yl)methoxy]phenyl}propan-2-yl)phenoxy]methyl}oxirane",,3072-84-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19397/7/4/2/?documentUUID=32ea6293-18c8-4530-b73c-780546b19bc1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C1=CC(=C(C(=C1)Br)OCC2CO2)Br)C3=CC(=C(C(=C3)Br)OCC4CO4)Br,https://pubchem.ncbi.nlm.nih.gov/compound/62250,PubChem,CC(C)(c1cc(Br)c(OCC2CO2)c(Br)c1)c1cc(Br)c(OCC2CO2)c(Br)c1,Test,1,2702,training
-"EU_REACH:
-N1,N4-bis(5-methylhexan-2-yl)benzene-1,4-diamine",,3081-14-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13514/7/4/2/?documentUUID=5aa00b2e-0c8e-4804-b487-208329f50bb7,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCC(C)NC1=CC=C(C=C1)NC(C)CCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/18320,PubChem,CC(C)CCC(C)Nc1ccc(NC(C)CCC(C)C)cc1,Train,1,2702,training
-"EU_REACH:
-tris{2-[2-(2-methoxyethoxy)ethoxy]ethyl} borate",,30989-05-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14522/7/4/2/?documentUUID=df2fe914-a533-45e4-9f45-bc67e178576f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,B(OCCOCCOCCOC)(OCCOCCOCCOC)OCCOCCOCCOC,https://pubchem.ncbi.nlm.nih.gov/compound/14402222,PubChem,COCCOCCOCCOB(OCCOCCOCCOC)OCCOCCOCCOC,Train,1,2702,training
-"JP_CHRIP:
-Decylbenzenesulfonic acid (C10)",,31093-47-7,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0332e.html,"JP_CHRIP:
-Based on the description in the report on human epidemiological studies (CERI-NITE Hazard Assessment No.5 (2005)): ""24 hour application of 1% aqueous solution of LAS induced moderate irritation."" The substance is thus considered a moderate irritant (LAS mixtures with carbon chain lengths of 10-14; no data available on decylbenzene sulfonic acid per se).",,JP_CHRIP,1,CCCCCCCCCCC1=CC=CC=C1S(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/169254,PubChem,CCCCCCCCCCc1ccccc1S(=O)(=O)O,Train,1,2702,training
-"AU_HCIS:
-1,3-Diazetidin-2-one, 1,3-bis[4-[(4-isocyanatophenyl)methyl]phenyl]-4-[[4-[(4-isocyanatophenyl)methyl]phenyl]imino]-",,31107-36-5,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1204,,,AU_HCIS,1,C1=CC(=CC=C1CC2=CC=C(C=C2)N=C3N(C(=O)N3C4=CC=C(C=C4)CC5=CC=C(C=C5)N=C=O)C6=CC=C(C=C6)CC7=CC=C(C=C7)N=C=O)N=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/161693,PubChem,O=C=Nc1ccc(Cc2ccc(N=C3N(c4ccc(Cc5ccc(N=C=O)cc5)cc4)C(=O)N3c3ccc(Cc4ccc(N=C=O)cc4)cc3)cc2)cc1,Train,1,2702,training
-"JP_CHRIP:
-3-Methyl-4-methylthiophenol","JP_CHRIP:
-3-Methyl-4-methylthiophenol",3120-74-9,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0120e.html,"JP_CHRIP:
-It was classified in Category 2 because it is reported that it was irritating in a skin irritation test with rabbits (IUCLID (2000)).",,JP_CHRIP,1,CSc1ccc(O)cc1C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J48.511J,J-GLOBAL,CSc1ccc(O)cc1C,Train,1,2702,training
-"JP_CHRIP:
-2-Methoxyethyl acrylate
-
-NZ_CCID:
-(2-Methoxyethyl) acrylate","JP_CHRIP:
-Methoxyethyl acrylate; 2-Methoxyethyl acrylate; 2-Propenioc acid, 2-methoxyethyl ester; 2-Propenoic acid, 2-methoxyethyl ester",3121-61-7,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0111e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2D20C51F-126A-4327-A524-168C4CB3BF6B","JP_CHRIP:
-In the rabbit test (OECD TG404), 4-hour application of 0.5 mL of the substance caused necrosis of epithelium in 2 of 3 animals after 1 and 2 days after application, and individual average scores of erythema was 4 (necrosis of epithelium after 3 days), 4 (necrosis of epithelium after 3 days) and 3, and of edema was 4, 4 and 2.7 (ECETOC TR (1995)). However, reversibility was observed and only eschar remained during observation period after application (ECETOC TR (1995)). Therefore, the substance was classified as Category 2.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",Provided,"JP_CHRIP, NZ_CCID",2,COCCOC(=O)C=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J55.297F,J-GLOBAL,C=CC(=O)OCCOC,Train,1,2702,training
-"JP_CHRIP:
-o-Chlorinated diphenyl oxide","JP_CHRIP:
-Benzene, 1,1'-oxybis-, hexachloro deriv
-Benzene, 1,1'-oxybis-, hexachloro deriv.",31242-93-0,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0676e.html,"JP_CHRIP:
-It was classified as Category 2 based on descriptions that severe skin irritations was seen on rabbits (HSFS (2000)) and that rash and warmth was caused within a short time after exposure on humans (ACGIH (2001)).",,JP_CHRIP,1,C1=CC(=C(C(=C1OC2=C(C(=C(C=C2)Cl)Cl)Cl)Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/92384,PubChem,Clc1ccc(Oc2ccc(Cl)c(Cl)c2Cl)c(Cl)c1Cl,Train,1,2702,training
-"NZ_CCID:
-4-Benzylpiperidine",,31252-42-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F3DF2EBA-5970-4A4C-A6C0-FA7977A020F7,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C1CNCCC1CC2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/31738,PubChem,c1ccc(CC2CCNCC2)cc1,Train,1,2702,training
-"EU_REACH:
-tris({[1,1'-biphenyl]-4-yl})-1,3,5-triazine",,31274-51-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13874/7/4/2/?documentUUID=2ba5b8aa-d8f8-41cb-beb7-b23c988aca5c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C2=CC=C(C=C2)C3=NC(=NC(=N3)C4=CC=C(C=C4)C5=CC=CC=C5)C6=CC=C(C=C6)C7=CC=CC=C7,https://pubchem.ncbi.nlm.nih.gov/compound/11628027,PubChem,c1ccc(-c2ccc(-c3nc(-c4ccc(-c5ccccc5)cc4)nc(-c4ccc(-c5ccccc5)cc4)n3)cc2)cc1,Train,1,2702,training
-"NZ_CCID:
-3-Bromobenzaldehyde",,3132-99-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/05085F4E-7862-41F4-A476-10F02FE30F50,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)Br)C=O,https://pubchem.ncbi.nlm.nih.gov/compound/76583,PubChem,O=Cc1cccc(Br)c1,Train,1,2702,training
-"EU_REACH:
-9-Anthracenecarboxylic acid, (triethoxysilyl)methyl ester",,313482-99-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31796/7/4/2/?documentUUID=4496a07b-03dd-4025-93c6-d3acf13e19bb,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](COC(=O)C1=C2C=CC=CC2=CC3=CC=CC=C31)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/12991882,PubChem,CCO[Si](COC(=O)c1c2ccccc2cc2ccccc12)(OCC)OCC,Train,1,2702,training
-"NZ_CCID:
-N,N'-Diacetylhydrazine","NZ_CCID:
-1,2-diacetylhydrazine",3148-73-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0C36060E-5A99-4675-A6D9-F0AC921F0918,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(=O)NNC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/72884,PubChem,CC(=O)NNC(C)=O,Train,1,2702,training
-"NZ_CCID:
-Cyclohexyl isocyanate",,3173-53-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F4F233DB-0143-4268-BBD9-84D5455688A4,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CCC(CC1)N=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/18502,PubChem,O=C=NC1CCCCC1,Train,1,2702,training
-"JP_CHRIP:
-1,5-naphthylene diisocyanate
-
-NZ_CCID:
-1,5-Naphthylene diisocyanate","JP_CHRIP:
-1,5-Naphthalene diisocyanate
-Naphthalene-1,5-diyl diisocyanate
-NDI",3173-72-6,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0061e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8C7713FB-4D57-4431-AA46-C54A05BA3D83","JP_CHRIP:
-The substance was found not to be irritating in human tests (IUCLID, 2000). On the other hand, rabbit tests yielded contradictory results: the substance caused severe irritation in one test and was not irritating in another (IUCLID, 2000). Based on the EU's classification of the substance into R36, 37, and 38 (EU-Annex 1, accessed in July 2008), it was classified into Category 2 taking the higher risk rating by the EU into account.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]
-Eye Irritation
-R PHRASE: R 36 [ECB]",,"JP_CHRIP, NZ_CCID",2,O=C=Nc1cccc2c(cccc12)N=C=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J41.091H,J-GLOBAL,O=C=Nc1cccc2c(N=C=O)cccc12,Train,1,2702,training
-"EU_REACH:
-2,2'-[(3,3'-dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-methoxyphenyl)-3-oxobutyramide]",,31775-16-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17245/7/4/2/?documentUUID=52d8c8bd-3455-4f21-b26c-a893c49d854a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC=C(C=C1)OC)N=NC2=C(C=C(C=C2)C3=CC(=C(C=C3)N=NC(C(=O)C)C(=O)NC4=CC=C(C=C4)OC)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/169359,PubChem,COc1ccc(NC(=O)C(N=Nc2ccc(-c3ccc(N=NC(C(C)=O)C(=O)Nc4ccc(OC)cc4)c(Cl)c3)cc2Cl)C(C)=O)cc1,Train,1,2702,training
-"EU_REACH:
-2,2'-[(3,3'-dichlorobiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis[N-(4-ethoxyphenyl)-3-oxobutanamide]",,31775-20-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11673/7/4/2/?documentUUID=16203664-2625-4b97-8d81-727ad79db938,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=CC=C(C=C1)NC(=O)C(C(=O)C)N=NC2=C(C=C(C=C2)C3=CC(=C(C=C3)N=NC(C(=O)C)C(=O)NC4=CC=C(C=C4)OCC)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/169360,PubChem,CCOc1ccc(NC(=O)C(N=Nc2ccc(-c3ccc(N=NC(C(C)=O)C(=O)Nc4ccc(OCC)cc4)c(Cl)c3)cc2Cl)C(C)=O)cc1,Train,1,2702,training
-"EU_REACH:
-butyl 2-({2-hydroxy-3-[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)carbamoyl]-1-naphthyl}diazenyl)benzoate",,31778-10-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15921/7/4/2/?documentUUID=46ddc12b-51f5-48cf-999d-3ace11c9e9d9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOC(=O)C1=CC=CC=C1N=NC2=C(C(=CC3=CC=CC=C32)C(=O)NC4=CC5=C(C=C4)NC(=O)N5)O,https://pubchem.ncbi.nlm.nih.gov/compound/161725,PubChem,CCCCOC(=O)c1ccccc1N=Nc1c(O)c(C(=O)Nc2ccc3[nH]c(=O)[nH]c3c2)cc2ccccc12,Train,1,2702,training
-"NZ_CCID:
-3-(Dimethylamino)-1-propanol",,3179-63-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DF0B869C-AC8E-49BD-A6F1-74783CB78064,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CN(C)CCCO,https://pubchem.ncbi.nlm.nih.gov/compound/76646,PubChem,CN(C)CCCO,Train,1,2702,training
-"AU_HCIS:
-Dodecanamide, N-[3-(dimethylamino)propyl]-",,3179-80-4,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6761,,,AU_HCIS,1,CCCCCCCCCCCC(=O)NCCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/51392,PubChem,CCCCCCCCCCCC(=O)NCCCN(C)C,Train,1,2702,training
-"EU_REACH:
-methyl 2-amino-5-fluorobenzoate",,319-24-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11929/7/4/2/?documentUUID=2da207b3-c3ff-4798-bff3-cc6bab66315e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=C(C=CC(=C1)F)N,https://pubchem.ncbi.nlm.nih.gov/compound/2783401,PubChem,COC(=O)c1cc(F)ccc1N,Train,1,2702,training
-"JP_CHRIP:
-1,2-Dichloro-3-nitrobenzene","JP_CHRIP:
-2,3-dichloro-1-nitrobenzene
-2,3-Dichloronitrobenzene
-Benzene, 1,2-dichloro-3-nitro-",3209-22-1,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0394e.html,"JP_CHRIP:
-Based on the description in the report on rabbit skin irritation tests (HSDB (2005)): ""The substance induced slight delipidation of the skin surface, with sloughing in days 7-10. At 24 hours, severe erythema and edema were evident. These irritant reactions gradually subsided and there was no injury in depth. The substance is thus considered to possess a severe skin irritation potential"" (though the results are not those of 4-hour application).",,JP_CHRIP,1,[O-][N+](=O)c1cccc(Cl)c1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.176H,J-GLOBAL,O=[N+]([O-])c1cccc(Cl)c1Cl,Train,1,2702,training
-"EU_REACH:
-(2S,3R,4S,5S,6R)-5-(benzoyloxy)-6-[(benzoyloxy)methyl]-4-{[(2S)-1-(benzyloxy)-3-cyclohexyl-1-oxopropan-2-yl]oxy}-2-(ethylsulfanyl)oxan-3-yl benzoate",,322761-81-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17923/7/4/2/?documentUUID=8433ebcf-63ba-4045-b91e-216185585edc,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCS[C@H]1[C@@H]([C@H]([C@H]([C@H](O1)COC(=O)C2=CC=CC=C2)OC(=O)C3=CC=CC=C3)O[C@@H](CC4CCCCC4)C(=O)OCC5=CC=CC=C5)OC(=O)C6=CC=CC=C6,https://pubchem.ncbi.nlm.nih.gov/compound/101058569,PubChem,CCS[C@@H]1O[C@H](COC(=O)c2ccccc2)[C@H](OC(=O)c2ccccc2)[C@H](O[C@@H](CC2CCCCC2)C(=O)OCc2ccccc2)[C@H]1OC(=O)c1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-4-Isopropyl-3-methylphenol",,3228-02-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0004e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified as ""Not classified"" from (1).
-
-[Evidence Data]
-(1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 72-hour observation), no skin irritation was seen (erythema/eschar score: 0/0/0, edema score: 0/0/0) (NICNAS IMAP (2016), REACH registration dossier (Accessed May 2020)).
-
-[Reference Data, etc.]
-(2) It is reported that in a skin irritation test with rabbits (n = 8) (semi-occlusive, 4-hour application, 72-hour observation), no erythema or edema was found in either an abraded skin group (4 animals) or an intact skin group (4 animals) at either 0.1% solution or 1% solution applied (NICNAS IMAP (2016)).",Provided,JP_CHRIP,1,CC(C)c1ccc(O)cc1C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J30.641J,J-GLOBAL,Cc1cc(O)ccc1C(C)C,Train,1,2702,training
-"EU_REACH:
-4-ethoxy-2,3-difluoro-4'-[(1s,4r)-4-ethylcyclohexyl]-1,1'-biphenyl",,323178-01-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24085/7/4/2/?documentUUID=0553804d-cd01-4a81-bd79-891eae2bd53f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1CCC(CC1)C2=CC=C(C=C2)C3=C(C(=C(C=C3)OCC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/58997815,PubChem,CCOc1ccc(-c2ccc(C3CCC(CC)CC3)cc2)c(F)c1F,Train,1,2702,training
-"AU_HCIS:
-Oxirane, dodecyl-",,3234-28-4,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5458,,,AU_HCIS,1,CCCCCCCCCCCCC1CO1,https://pubchem.ncbi.nlm.nih.gov/compound/18604,PubChem,CCCCCCCCCCCCC1CO1,Train,1,2702,training
-"EU_CLP:
-9,9-bis(4-hydroxyphenyl)fluorene",,3236-71-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC=C2C(=C1)C3=CC=CC=C3C2(C4=CC=C(C=C4)O)C5=CC=C(C=C5)O,https://pubchem.ncbi.nlm.nih.gov/compound/76716,PubChem,Oc1ccc(C2(c3ccc(O)cc3)c3ccccc3-c3ccccc32)cc1,Test,1,2702,training
-"EU_REACH:
-3-amino-2,2-dimethylpropanamide",,324763-51-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19104/7/4/2/?documentUUID=95990132-6b45-42fc-9985-54305e7f9f45,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(CN)C(=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/11159315,PubChem,CC(C)(CN)C(N)=O,Train,1,2702,training
-"EU_REACH:
-2-tetradecyloctadecan-1-ol",,32582-32-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12081/7/4/2/?documentUUID=90362e6a-1883-44dd-aec3-1f175fe06d10,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCC(CCCCCCCCCCCCCC)CO,https://pubchem.ncbi.nlm.nih.gov/compound/94435,PubChem,CCCCCCCCCCCCCCCCC(CO)CCCCCCCCCCCCCC,Train,1,2702,training
-"JP_CHRIP:
-3-(Methylsulfanyl)propanal
-
-NZ_CCID:
-3-(Methylthio)-propionaldehyde
-
-US_HSDB:
-4-Thiapentanal","JP_CHRIP:
-beta-(Methylmercapto) propionaldehyde
-beta-(Methylthio) propionaldehyde
-Methional
-
-NZ_CCID:
-methional",3268-49-3,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-meti-0065e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0FF083AF-E349-4033-A542-18AE9632DF16
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8499","JP_CHRIP:
-A result of ""slight irritation"" and that of ""necrosis"" are described in SIDS (2003) for the 4-hour skin irritation test using rabbits. Since SIDS (2003) has drawn a conclusion, ""There is skin irritation,"" based on many experimental results including these, it was classified in Category 2.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,CSCCC=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J13.022B,J-GLOBAL,CSCCC=O,Train,1,2702,training
-"EU_REACH:
-4'-ethyl-3-fluoro-4-(3,4,5-trifluorophenyl)-1,1'-biphenyl",,326894-55-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30439/7/4/2/?documentUUID=edae4d50-97f9-416a-b646-61f5b03895e4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1=CC=C(C=C1)C2=CC(=C(C=C2)C3=CC(=C(C(=C3)F)F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/12010663,PubChem,CCc1ccc(-c2ccc(-c3cc(F)c(F)c(F)c3)c(F)c2)cc1,Train,1,2702,training
-"EU_REACH:
-2-(2-methylbutan-2-yl)phenol",,3279-27-4,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17108/7/4/2/?documentUUID=628910cd-0e61-4f39-b56c-78250004ffba,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)(C)C1=CC=CC=C1O,https://pubchem.ncbi.nlm.nih.gov/compound/76769,PubChem,CCC(C)(C)c1ccccc1O,Train,1,2702,training
-"NZ_CCID:
-Methyl 4-chloroacetoacetate",,32807-28-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7BD3F552-461A-49B9-A8B7-DED873FECB86,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,COC(=O)CC(=O)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/36240,PubChem,COC(=O)CC(=O)CCl,Train,1,2702,training
-"JP_CHRIP:
-2,2-Dimethylpropanoyl chloride
-
-NZ_CCID:
-Pivaloyl chloride","JP_CHRIP:
-Pivaloyl chloride",3282-30-2,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0095e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5037F815-1BC7-4009-83E5-2088A00F3727","JP_CHRIP:
-In a test semi-occlusive applied 0.5 mL of undiluted this substance to six rabbit skins for 4 hours (GLP compliance), erythema and edema were observed until 21 days after application, a maximum irritation score was 7.0/8.0, necrosis was present on the application sites in all six animals, and this substance was assessed as corrosive. (SIDS (2011))
-Therefore it was classified in Category 1.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CC(C)(C)C(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J33.810I,J-GLOBAL,CC(C)(C)C(=O)Cl,Train,1,2702,training
-"NZ_CCID:
-3,5-Bis(trifluoromethyl)-1-bromobenzene","NZ_CCID:
-3,5-bis(trifluoromethyl)bromobenzene",328-70-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5ABA9ADB-CD42-4A4B-A541-9B2DADEA2C2A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=C(C=C(C=C1C(F)(F)F)Br)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/67602,PubChem,FC(F)(F)c1cc(Br)cc(C(F)(F)F)c1,Train,1,2702,training
-"EU_REACH:
-1,2-dichloro-4-(trifluoromethyl)benzene
-
-JP_CHRIP:
-1,2-Dichloro-4-(trifluoromethyl)benzene","JP_CHRIP:
-3,4-Dichloro-alpha,alpha,alpha-trifluorotoluene
-3,4-Dichlorobenzotrifluoride
-Benzene, 1,2-dichloro-4-(trifluoromethyl)-; 3,4-Dichlorobenzotrifluoride",328-84-7,Cat 2,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27050/7/4/2/?documentUUID=b3409edd-1b59-4a6c-916f-028daeefde19
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0025e.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-Because a PII (primary irritation index) of 2.75 in a test of an occlusive application of 0.5 mL of an undiluted test substance to rabbit skins and a PII of 4.3 in another test of an occlusive application of 0.5 mL of the undiluted test substance to rabbit skin for 24 hours were both assessed as moderately irritating (US EPA/HPV (2008)), it was classified in Category 2.",Provided,"EU_REACH, JP_CHRIP",2,FC(F)(F)c1ccc(Cl)c(Cl)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J31.770E,J-GLOBAL,FC(F)(F)c1ccc(Cl)c(Cl)c1,Train,1,2702,training
-"EU_REACH:
-(acetyloxy)(methyl)(propan-2-yloxy)silyl acetate",,329039-38-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8884/7/4/2/?documentUUID=82be1ab5-8333-4dde-b45c-6a89b08f0759,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)O[Si](C)(OC(=O)C)OC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/23344072,PubChem,CC(=O)O[Si](C)(OC(C)=O)OC(C)C,Train,1,2702,training
-"NZ_CCID:
-Trimethylolpropane trimethacrylate, >10% in a non hazardous diluent",,3290-92-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6005E324-D509-4F08-9587-49A920BB0FA8,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,CCC(COC(=O)C(=C)C)(COC(=O)C(=C)C)COC(=O)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/18689,PubChem,C=C(C)C(=O)OCC(CC)(COC(=O)C(=C)C)COC(=O)C(=C)C,Train,1,2702,training
-"NZ_CCID:
-Phenylmethanesulphonyl fluoride",,329-98-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/337271B3-D0D4-4021-BEE4-CB3195DFC99E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)CS(=O)(=O)F,https://pubchem.ncbi.nlm.nih.gov/compound/4784,PubChem,O=S(=O)(F)Cc1ccccc1,Train,1,2702,training
-"EU_REACH:
-2,2-bis({[(3-sulfanylpropanoyl)oxy]methyl})butyl 3-sulfanylpropanoate",,33007-83-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25116/7/4/2/?documentUUID=11404f50-6d11-4827-a803-887712bfd13e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(COC(=O)CCS)(COC(=O)CCS)COC(=O)CCS,https://pubchem.ncbi.nlm.nih.gov/compound/118379,PubChem,CCC(COC(=O)CCS)(COC(=O)CCS)COC(=O)CCS,Train,1,2702,training
-"EU_REACH:
-3,5,5-trimethylhexanoic acid",,3302-10-1,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13645/7/4/2/?documentUUID=0cf9b507-0b37-45ce-90d2-11964e43eab5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CC(=O)O)CC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/90960,PubChem,CC(CC(=O)O)CC(C)(C)C,Train,1,2702,training
-"EU_REACH:
-3-phenyl-5-(thiophen-2-yl)-1,2,4-oxadiazole",,330459-31-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16543/7/4/2/?documentUUID=57402669-bea4-4d23-a970-8c4dbf7d712a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C2=NOC(=N2)C3=CC=CS3,https://pubchem.ncbi.nlm.nih.gov/compound/695679,PubChem,c1ccc(-c2noc(-c3cccs3)n2)cc1,Train,1,2702,training
-"JP_CHRIP:
-3-(3,4-Dichlorophenyl)-1,1-dimethylurea; Diuron","JP_CHRIP:
-N-(3,4-dichlorophenyl)-N',N'-dimethylurea",330-54-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2066e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified as ""Not classified"" from (1) - (3). The classification result was changed due to new data (1) - (3) obtained.
-
-[Evidence Data]
-(1) In a skin irritation test with rabbits according to EPA OPPTS 870.2500, all irritation reactions cleared by 72 hours (EPA Pesticides RED (2003)).
-(2) In an irritation test on the forearms of human volunteers, no irritation was seen (GESTIS (Access on May 2020)).
-(3) In a skin irritation test with rabbits according to OECD TG 404, the mean score at 24/48/72 hours after application was all 0 (REACH registration dossier (Access on September 2020)).
-
-[Reference Data, etc.]
-(4) This substance may irritate the skin and eye in humans (ACGIH (7th, 2001), HSDB (Access on May 2020)).
-(5) In a skin irritation test with rabbits by 24-hour application, it was irritating (GESTIS (Access on May 2020)).
-(6) In a skin irritation test in which 50% paste (0.05 g) of this substance was applied to the guinea pig skin, it was slightly irritating (Agricultural Chemicals Times supplement ""Agricultural chemicals technology information"" No. 8 (Japan Crop Protection Association, 1991)).",Provided,JP_CHRIP,1,CN(C)C(=O)Nc1ccc(Cl)c(Cl)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J30.227I,J-GLOBAL,CN(C)C(=O)Nc1ccc(Cl)c(Cl)c1,Train,1,2702,training
-"EU_REACH:
-2-[1-(2-hydroxy-3,5-dimethylphenyl)-2-methylpropyl]-4,6-dimethylphenol",,33145-10-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22036/7/4/2/?documentUUID=ac47212e-6b84-4f9a-81a0-7190958e241e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C(=C1)C(C2=CC(=CC(=C2O)C)C)C(C)C)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/94446,PubChem,Cc1cc(C)c(O)c(C(c2cc(C)cc(C)c2O)C(C)C)c1,Train,1,2702,training
-"NZ_CCID:
-4-Nitrocatechol",,3316-09-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9A6F33F9-0AE3-46CD-B3FA-8301C02DA9D6,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 35 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC(=C(C=C1[N+](=O)[O-])O)O,https://pubchem.ncbi.nlm.nih.gov/compound/3505109,PubChem,O=[N+]([O-])c1ccc(O)c(O)c1,Train,1,2702,training
-"EU_REACH:
-dimethyl(tetradecyl)amine oxide",,3332-27-2,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14677/7/4/2/?documentUUID=468a3b25-771d-4acb-82ed-a7a048c846f1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCC[N+](C)(C)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/18739,PubChem,CCCCCCCCCCCCCC[N+](C)(C)[O-],Train,1,2702,training
-"NZ_CCID:
-Methyl trifluoromethanesulphonate","NZ_CCID:
-Methyl triflate",333-27-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/21D47FB0-6821-49E0-9F0A-CD2893817B84,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,COS(=O)(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/9526,PubChem,COS(=O)(=O)C(F)(F)F,Train,1,2702,training
-"JP_CHRIP:
-Decanoic acid
-
-NZ_CCID:
-Decanoic acid","NZ_CCID:
-Capric acid, n-Capric acid, n-Decanoic acid",334-48-5,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-meti-0033e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A355031E-5019-42F8-84B9-ACAE11183C5B","JP_CHRIP:
-Since there is a description, ""moderately to severely irritating"" (IUCLID (2000)) in the 24-hour administration study with rabbits, it was classified in Category 2.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Decanoic Acid is a moderate to severe skin irritant when applied undiluted to intact or abraded rabbit skin for 24 hours.
-REFERENCE SOURCE: [USEPA]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Capric acid (mixed isomers) produces severe corneal burns when applied as a 5 percent solution (0.5 ml in water or propylene glycol) to rabbit eyes.
-REFERENCE SOURCE:[Clayton, G.D., F.E. Clayton (eds.) Pattys Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994. 3560]**PEER REVIEWED**",,"JP_CHRIP, NZ_CCID",2,CCCCCCCCCC(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.575E,J-GLOBAL,CCCCCCCCCC(=O)O,Train,1,2702,training
-"JP_CHRIP:
-Perfluorooctanic acid","JP_CHRIP:
-Octanoic acid, 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluoro-
-Octanoic acid, pentadecafluoro-
-Pentadecafluoro-n-octanoic acid
-Pentadecafluorooctanoic acid
-Pentadecafluorooctanoic acid; Pentadecafluoro-1-octanoic acid; Perfluorooctanoic acid
-Perfluorocaprylic acid
-Perfluorooctanoic acid",335-67-1,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0049e.html,"JP_CHRIP:
-There is no specific information, but because it is written that this substance is irritating to skin (Result of the initial environmental risk assessment of chemicals, Vol. 9, Ministry of the Environment in Japan (2011)), it was classified in Category 2.",,JP_CHRIP,1,OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J65.650J,J-GLOBAL,O=C(O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train,1,2702,training
-"NZ_CCID:
-Bis(heptafluorobutyric) anhydride","NZ_CCID:
-heptafluorobutyric anhydride",336-59-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A47FC683-37C2-496E-B473-91341AA8AB3F,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(=O)(C(C(C(F)(F)F)(F)F)(F)F)OC(=O)C(C(C(F)(F)F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/67643,PubChem,O=C(OC(=O)C(F)(F)C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)C(F)(F)F,Train,1,2702,training
-"EU_REACH:
-Methyl (2S,3R)-2-amino-3-hydroxy-butanoate",,3373-59-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32138/7/4/2/?documentUUID=d43404b4-e277-401a-8d55-8230391f98f7,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@H]([C@@H](C(=O)OC)N)O,https://pubchem.ncbi.nlm.nih.gov/compound/2734894,PubChem,COC(=O)[C@@H](N)[C@@H](C)O,Train,1,2702,training
-"NZ_CCID:
-Benzenemethanamine, N-(1,1-dimethylethyl)-","NZ_CCID:
-N-(tert-butyl)benzylamine, N-Benzyl-tert-butylamine",3378-72-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/571DAD77-804D-4A7B-932B-621A617AD99F,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)(C)NCC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/76908,PubChem,CC(C)(C)NCc1ccccc1,Train,1,2702,training
-"EU_REACH:
-5-chloro-2-(4-chlorophenoxy)phenol",,3380-30-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12528/7/4/2/?documentUUID=a5cd10ab-a44b-4ede-946e-9dcd350bfd82,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1OC2=C(C=C(C=C2)Cl)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/18807,PubChem,Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1,Train,1,2702,training
-"EU_CLP:
-triclosan; 2,4,4'-trichloro-2'-hydroxy-diphenyl-ether; 5-chloro-2-(2,4-dichlorophenoxy)phenol",,3380-34-5,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC(=C(C=C1Cl)O)OC2=C(C=C(C=C2)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/5564,PubChem,Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl,Test,1,2702,training
-"EU_REACH:
-1-chlorooctadecane",,3386-33-2,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1479/7/4/2/?documentUUID=a6f38592-620c-4740-ac44-7bef5c69b991,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCCCCl,https://pubchem.ncbi.nlm.nih.gov/compound/18815,PubChem,CCCCCCCCCCCCCCCCCCCl,Test,1,2702,training
-"EU_REACH:
-2-chloro-1,1-difluoroethane",,338-65-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12121/7/4/2/?documentUUID=eb9a6452-2954-49c6-aeae-3d37b1fa5eaa,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(C(F)F)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/2736499,PubChem,FC(F)CCl,Train,1,2702,training
-"KR_NCIS:
-6,6-Dimethylbicyclo[3.1.1]hept-2-ene-2-propanal",,33885-51-7,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CC1(C2CC=C(C1C2)CCC=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/118111,PubChem,CC1(C)C2CC=C(CCC=O)C1C2,Train,1,2702,training
-"EU_REACH:
-4-methyl-2,2,4,6,6-pentaphenyl-3,5-dioxa-2,4,6-trisilaheptane",,3390-61-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24084/7/4/2/?documentUUID=dc889756-e737-46ef-ab03-614687e1a6d5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](C1=CC=CC=C1)(C2=CC=CC=C2)O[Si](C)(C3=CC=CC=C3)O[Si](C)(C4=CC=CC=C4)C5=CC=CC=C5,https://pubchem.ncbi.nlm.nih.gov/compound/76925,PubChem,C[Si](O[Si](C)(c1ccccc1)c1ccccc1)(O[Si](C)(c1ccccc1)c1ccccc1)c1ccccc1,Train,1,2702,training
-"EU_REACH:
-1H-benzo[10,5]anthra[2,1,9-def]isoquinoline-1,3(2H)-dione",,33955-44-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7530/7/4/2/?documentUUID=a59cfc9d-3d32-4c7c-87ce-316d7ecd2a8f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=C3C(=C1)C4=C5C(=CC=C6C5=C(C=C4)C(=O)NC6=O)C3=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/11759047,PubChem,O=C1NC(=O)c2ccc3c4cccc5cccc(c6ccc1c2c63)c54,Train,1,2702,training
-"NZ_CCID:
-Methyl 3-bromopropionate",,3395-91-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CEDEBF16-F105-4058-93CB-E0E2E59E07C5,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,COC(=O)CCBr,https://pubchem.ncbi.nlm.nih.gov/compound/76934,PubChem,COC(=O)CCBr,Train,1,2702,training
-"NZ_CCID:
-Cyclopentanecarboxylic acid",,3400-45-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1467832A-FDF9-497C-B81C-8FAC92BF0B86,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1CCC(C1)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/18840,PubChem,O=C(O)C1CCCC1,Train,1,2702,training
-"NZ_CCID:
-Silicon tetraisocyanate",,3410-77-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/53D6098A-8D8A-40C1-9AF8-08314E0EC3CB,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(=N[Si](N=C=O)(N=C=O)N=C=O)=O,https://pubchem.ncbi.nlm.nih.gov/compound/76951,PubChem,O=C=N[Si](N=C=O)(N=C=O)N=C=O,Train,1,2702,training
-"EU_REACH:
-endo-8-isopropyl-8-azabicyclo[3.2.1]octan-3-ol",,3423-25-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7959/7/4/2/?documentUUID=5142dcef-74fa-494f-a5b9-a9d54ad5ddb0,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)N1C2CCC1CC(C2)O,https://pubchem.ncbi.nlm.nih.gov/compound/103007,PubChem,CC(C)N1C2CCC1CC(O)C2,Train,1,2702,training
-"EU_REACH:
-8-isopropyl-8-azabicyclo[3.2.1]octan-3-one",,3423-28-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8201/7/4/2/?documentUUID=211d17d9-07f8-4292-975b-e8e95ca8d2d4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)N1C2CCC1CC(=O)C2,https://pubchem.ncbi.nlm.nih.gov/compound/103009,PubChem,CC(C)N1C2CCC1CC(=O)C2,Train,1,2702,training
-"EU_REACH:
-2-methylbutane-2-peroxol",,3425-61-4,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5881/7/4/2/?documentUUID=2ac43cd2-557f-4351-b8b7-92e42879a792,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)(C)OO,https://pubchem.ncbi.nlm.nih.gov/compound/76962,PubChem,CCC(C)(C)OO,Train,1,2702,training
-"NZ_CCID:
-Acetochlor",,34256-82-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/79BC3D6A-42C6-4FA7-8FEC-079D0101CDF3,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R38. [NCLASS]
-Eye Irritation
-Practically non-irritating to eyes and skin (rabbits).
-[PESTICIDES MANUAL]",,NZ_CCID,1,CCC1=CC=CC(=C1N(COCC)C(=O)CCl)C,https://pubchem.ncbi.nlm.nih.gov/compound/1988,PubChem,CCOCN(C(=O)CCl)c1c(C)cccc1CC,Train,1,2702,training
-"NZ_CCID:
-2-Bromobenzyl bromide",,3433-80-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2F04F47D-878A-446A-978E-52D1DFEDF166,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)CBr)Br,https://pubchem.ncbi.nlm.nih.gov/compound/76965,PubChem,BrCc1ccccc1Br,Train,1,2702,training
-"EU_REACH:
-Octadecanamide, N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl]-",,34354-88-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24105/7/4/2/?documentUUID=07fe97f5-567e-499a-ad8a-713ddc6ebc08,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@@H]([C@@H](CCCCCCCCCCCCCC)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/9898642,PubChem,CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC,Train,1,2702,training
-"EU_REACH:
-2-methylpropanoyl 2-methylpropaneperoxoate",,3437-84-1,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11632/7/4/2/?documentUUID=19fd82bb-83ae-46ab-af44-ce1c89ab6284,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C(=O)OOC(=O)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/76969,PubChem,CC(C)C(=O)OOC(=O)C(C)C,Train,1,2702,training
-"EU_REACH:
-butyl 2-hydroxypropanoate",,34451-19-9,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24344/7/4/2/?documentUUID=fb3b09bf-41b5-419a-a127-309a33405e2f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOC(=O)[C@H](C)O,https://pubchem.ncbi.nlm.nih.gov/compound/6999977,PubChem,CCCCOC(=O)[C@H](C)O,Train,1,2702,training
-"EU_REACH:
-1,1,2,2,3,3,4,4,4-nonafluoro-N-(2-hydroxyethyl)-N-methylbutane-1-sulfonamide",,34454-97-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5299/7/4/2/?documentUUID=40bc5d99-f010-41fd-971e-0e1579669ae2,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(CCO)S(=O)(=O)C(C(C(C(F)(F)F)(F)F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/118688,PubChem,CN(CCO)S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train,1,2702,training
-"EU_REACH:
-1,1,2,2,3,3,4,4,4-nonafluoro-N,N-bis(2-hydroxyethyl)butane-1-sulfonamide",,34455-00-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27023/7/4/2/?documentUUID=7417842f-6f35-4819-96fd-cc2c220e6055,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CO)N(CCO)S(=O)(=O)C(C(C(C(F)(F)F)(F)F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/118689,PubChem,O=S(=O)(N(CCO)CCO)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train,1,2702,training
-"EU_REACH:
-N-(carboxymethyl)-N,N-dimethyl-3-{[(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)sulfonyl]amino}propan-1-aminium hydroxide",,34455-29-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17549/7/4/2/?documentUUID=24640f75-c8c1-4a68-8e83-69e4ca8f5d67,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[N+](C)(CCCNS(=O)(=O)CCC(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)CC(=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/118691,PubChem,C[N+](C)(CCCNS(=O)(=O)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)CC(=O)[O-],Train,1,2702,training
-"ChemSkin:
-4-Methylthio-benzaldehyde #",,3446-89-7,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,CSC1=CC=C(C=C1)C=O,https://pubchem.ncbi.nlm.nih.gov/compound/76985,PubChem,CSc1ccc(C=O)cc1,Test,1,2702,training
-"JP_CHRIP:
-3,5,5-Trimethyl-1-hexanol","JP_CHRIP:
-3,5,5-Trimethyl-1-hexanol
-3,5,5-trimethylhexan-1-ol
-3,5,5-Trimethylhexylalcohol
-Isononyl alcohol",3452-97-9,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0441e.html,"JP_CHRIP:
-Based on the description in the report on rabbit skin irritation tests (4-hour application) (SIDS (2003)): ""Draize scores for 24, 48, and 72 hours: Erythema = 1.83, Edema = 0.22 and PII = 2.08"" and ""moderate irritation.""",,JP_CHRIP,1,CC(CCO)CC(C)(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J142.877B,J-GLOBAL,CC(CCO)CC(C)(C)C,Train,1,2702,training
-"NZ_CCID:
-2-Fluorobenzyl chloride",,345-35-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B9A1C874-1106-49B9-AF9E-98AA441BF8CB,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)CCl)F,https://pubchem.ncbi.nlm.nih.gov/compound/9580,PubChem,Fc1ccccc1CCl,Train,1,2702,training
-"EU_REACH:
-N-(2,5-dimethoxyphenyl)acetamide",,3467-59-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5639/7/4/2/?documentUUID=b690b860-1db5-42be-bd36-4333ed4cfd8d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)NC1=C(C=CC(=C1)OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/77015,PubChem,COc1ccc(OC)c(NC(C)=O)c1,Train,1,2702,training
-"EU_REACH:
-1-butylpyrrolidin-2-one",,3470-98-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10579/7/4/2/?documentUUID=32866bf0-c291-4561-a4de-2e6444461078,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCN1CCCC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/18984,PubChem,CCCCN1CCCC1=O,Test,1,2702,training
-"NZ_CCID:
-2-Fluoroaniline",,348-54-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2B2451E2-FB4A-45AA-970C-B93048FCCDB4,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)N)F,https://pubchem.ncbi.nlm.nih.gov/compound/9584,PubChem,Nc1ccccc1F,Train,1,2702,training
-"NZ_CCID:
-1-Bromo-2,4-difluorobenzene",,348-57-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A60BD485-AEC2-4CFB-94C8-DA2392ABE2A6,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C=C1F)F)Br,https://pubchem.ncbi.nlm.nih.gov/compound/67674,PubChem,Fc1ccc(Br)c(F)c1,Train,1,2702,training
-"NZ_CCID:
-1-Bromo-3,4-difluorobenzene",,348-61-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2F57D1BD-5D56-43B5-A524-DD1F19AE6E70,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C1=CC(=C(C=C1Br)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/67675,PubChem,Fc1ccc(Br)cc1F,Train,1,2702,training
-"NZ_CCID:
-Methyl 3-pyridyl ketone","NZ_CCID:
-3-acetylpyridine",350-03-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A1A84DD3-E94A-4F86-896B-0F5E7B5CDA91,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CC(=O)C1=CN=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/9589,PubChem,CC(=O)c1cccnc1,Train,1,2702,training
-"ChemSkin:
-3-Chloro-4-fluoronitrobenzene",,350-30-1,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,C1=CC(=C(C=C1[N+](=O)[O-])Cl)F,https://pubchem.ncbi.nlm.nih.gov/compound/67688,PubChem,O=[N+]([O-])c1ccc(F)c(Cl)c1,Test,1,2702,training
-"EU_REACH:
-methyl 3,6-dichloro-4-acetamidopyridine-2-carboxylate",,350601-49-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12238/7/4/2/?documentUUID=1beab499-6cdf-46e5-88b3-746c32b11eb6,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)NC1=CC(=NC(=C1Cl)C(=O)OC)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/22677481,PubChem,COC(=O)c1nc(Cl)cc(NC(C)=O)c1Cl,Test,1,2702,training
-"NZ_CCID:
-Boron tris (trifluoroacetate)",,350-70-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/336E57B3-477A-4A8E-9B92-C9045F80ABCE,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,B(OC(=O)C(F)(F)F)(OC(=O)C(F)(F)F)OC(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/67693,PubChem,O=C(OB(OC(=O)C(F)(F)F)OC(=O)C(F)(F)F)C(F)(F)F,Train,1,2702,training
-"EU_REACH:
-1-[4-(benzyloxy)phenyl]-2-bromopropan-1-one",,35081-45-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20724/7/4/2/?documentUUID=15ce1cbc-65dc-4539-b16a-c1552b491c8f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C(=O)C1=CC=C(C=C1)OCC2=CC=CC=C2)Br,https://pubchem.ncbi.nlm.nih.gov/compound/100040,PubChem,CC(Br)C(=O)c1ccc(OCc2ccccc2)cc1,Train,1,2702,training
-"EU_REACH:
-4-(methoxycarbonyl)-3-nitrobenzoic acid",,35092-89-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5758/7/4/2/?documentUUID=e5f1c75a-329a-4e6a-bc04-e9675729425d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=C(C=C(C=C1)C(=O)O)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/98592,PubChem,COC(=O)c1ccc(C(=O)O)cc1[N+](=O)[O-],Train,1,2702,training
-"EU_REACH:
-2-ISOPROPYL-1,3-DIOXANE-5,5-DICARBOXYLIC ACID DIETHYL ESTER",,35113-48-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5703/7/4/2/?documentUUID=d929f706-4bd3-4333-881c-e7d85a5d926b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1(COC(OC1)C(C)C)C(=O)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/12502784,PubChem,CCOC(=O)C1(C(=O)OCC)COC(C(C)C)OC1,Test,1,2702,training
-"EU_REACH:
-2-hydroxy-N,N-dimethylpropanamide",,35123-06-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11068/7/4/2/?documentUUID=d8ca089a-e466-45d2-b8d3-a06af6f36f0a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C(=O)N(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/98053,PubChem,CC(O)C(=O)N(C)C,Train,1,2702,training
-"EU_REACH:
-methyl 2-[(ethoxymethanethioyl)sulfanyl]propanoate",,351491-23-1,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8998/7/4/2/?documentUUID=7c502417-df1c-4268-a302-dba9f12eec2d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=S)SC(C)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/16720359,PubChem,CCOC(=S)SC(C)C(=O)OC,Train,1,2702,training
-"NZ_CCID:
-(S)-(+)-1,1'-Binaphthalene-2,2'-diyl-phosphate",,35193-64-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9E6A9A8F-D835-4D6D-B449-3B2E992DB1CC,"NZ_CCID:
-Skin Irritation
-PHRASE: R 38 [Company Data]",,NZ_CCID,1,C1=CC=C2C(=C1)C=CC3=C2C4=C(C=CC5=CC=CC=C54)OP(=O)(O3)O,https://pubchem.ncbi.nlm.nih.gov/compound/99589,PubChem,O=P1(O)Oc2ccc3ccccc3c2-c2c(ccc3ccccc23)O1,Train,1,2702,training
-"EU_REACH:
-4,4'-[(3,3'-dichlorobiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis(5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one)",,3520-72-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15775/7/4/2/?documentUUID=4540df1b-e1da-430d-9523-8d1abfbed98c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC\1=NN(C(=O)C1=N/Nc2ccc(cc2Cl)c3ccc(N\N=C4/C(=NN(C4=O)c5ccccc5)C)c(Cl)c3)c6ccccc6,https://cactus.nci.nih.gov/chemical/structure/3520-72-7/smiles,CACTUS,CC1=NN(c2ccccc2)C(=O)/C1=N/Nc1ccc(-c2ccc(N/N=C3/C(=O)N(c4ccccc4)N=C3C)c(Cl)c2)cc1Cl,Train,1,2702,training
-"NZ_CCID:
-4-Fluorobenzyl chloride",,352-11-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FF911EC7-380A-42FE-ABD8-7CB9419BBFCF,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1CCl)F,https://pubchem.ncbi.nlm.nih.gov/compound/9602,PubChem,Fc1ccc(CCl)cc1,Train,1,2702,training
-"EU_REACH:
-(2-fluoro-3-methoxyphenyl)boronic acid",,352303-67-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30900/7/4/2/?documentUUID=8a810fc9-0288-461e-8cd4-a8b8cd0506ba,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,B(C1=C(C(=CC=C1)OC)F)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/4985744,PubChem,COc1cccc(B(O)O)c1F,Train,1,2702,training
-"JP_CHRIP:
-Pentaerythritol triacrylate
-
-NZ_CCID:
-2-Propenoic acid, 2-(hydroxymethyl)-2-[[(1-oxo-2-propenyl)oxy]methyl]-1,3-propanediyl ester","JP_CHRIP:
-Pentaerythritol triacrylate
-
-NZ_CCID:
-SR 444C, Tetramethylolmethane triacrylate, 2-Propenoic acid, 2-(hydroxymethyl)-2-(((1-oxo-2-propenyl)oxy)methyl)-1,3-propanediyl ester, Acrylic acid, triester with pentaerythritol, Aronix M 305, Gafgard 233, Kayarad PET 30, Light Acrylate PE 3A, NK Ester TMM 50T, P 300 (acrylate), Pentaerythritol triacrylate, Pentaerythrityl triacrylate, PETA, Sartomer SR 444, Setalux UV 2242, SR 444",3524-68-3,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2024e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C85C95B6-BC0D-4CB6-AE90-E005C721AF68","JP_CHRIP:
-[Rationale for the Classification]
-It is impossible to use (2) and (3) for classification judgment because the details of these tests are unknown. However, by considering (1) and (4), it seems appropriate to classify this substance as irritating to the skin, therefore it was classified in Category 2.
-
-[Evidence Data]
-(1) There is a report that this substance is irritating (GESTIS (Accessed Sept. 2018)).
-
-[Reference Data, etc.]
-(2) There is a report that, as a result of applying solutions of this substance in acetone to mice and rats, inflammation suggesting skin irritation, ulcers and epidermal degeneration, etc. were observed (GESTIS (Accessed Sept. 2018)).
-(3) There is a report that as a result of applying the undiluted liquid of this substance to rabbits for 24 hours, mild reddening (2 on a scale of 1 to 10) was observed (GESTIS (Accessed Sept. 2018)).
-(4) It is classified in Skin Irrit. 2 by EU CLP.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Low to moderate
-REFERENCE SOURCE: Carpenter, C.P., Weil, C.S., and Smyth, H.F., ""Range Finding Toxicity Data: List VIII."" Toxicology and Applied Pharmacology, Vol. 28 (1974), pp. 313-319. DePass, L.R., ""Carcinogenicity Testing of Photocurable Coatings."" Radiation Curing, Vol. 9, No. 3 (1982), pp. 18, 20, 22, 24.
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Severe to Corrosive effects. Graded 10 on a scale of 1-10 (10 being the worst).
-REFERENCE SOURCE: Carpenter, C.P., Weil, C.S., and Smyth, H.F., ""Range Finding Toxicity Data: List VIII."" Toxicology and Applied Pharmacology, Vol. 28 (1974), pp. 313-319. [ntp]",,"JP_CHRIP, NZ_CCID",2,OCC(COC(=O)C=C)(COC(=O)C=C)COC(=O)C=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J13.724C,J-GLOBAL,C=CC(=O)OCC(CO)(COC(=O)C=C)COC(=O)C=C,Train,1,2702,training
-"EU_REACH:
-2,2,2-trifluoroethyl methacrylate",,352-87-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18658/7/4/2/?documentUUID=20524d67-af6d-453a-a6bc-35f3dd754473,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OCC(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/9608,PubChem,C=C(C)C(=O)OCC(F)(F)F,Train,1,2702,training
-"NZ_CCID:
-Ethane, 1,1'-thiobis-","NZ_CCID:
-Ethyl thioether, Ethylthioethane",352-93-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/13068D85-8D76-40E4-9C5A-0155A52FF2B8,"NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Moderate
-REFERENCE SOURCE: [Prehled Prumyslove Toxikologie; Organicke Latky, Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 (-,991,1986)] [RTECS]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Mild
-REFERENCE SOURCE: [Prehled Prumyslove Toxikologie; Organicke Latky, Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 (-,991,1986)] [RTECS]",,NZ_CCID,1,CCSCC,https://pubchem.ncbi.nlm.nih.gov/compound/9609,PubChem,CCSCC,Train,1,2702,training
-"JP_CHRIP:
-carbonyl difluoride","JP_CHRIP:
-Carbon difluoride oxide
-Carbon oxyfluoride
-Carbonic difluoride
-Difluoroformaldehyde
-Fluorophosgene",353-50-4,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0910e.html,"JP_CHRIP:
-It was set as Category 2 from description that the skin was stimulated (ICSC (J)(2003), HSDB (2005), HSFS (1999), SITTIG (4th, 2002)).",,JP_CHRIP,1,FC(=O)F,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.579H,J-GLOBAL,O=C(F)F,Train,1,2702,training
-"NZ_CCID:
-2-Iodo-1,1,1-trifluoroethane",,353-83-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0506DEE3-CB58-4631-9EC0-AD6695A9B840,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(C(F)(F)F)I,https://pubchem.ncbi.nlm.nih.gov/compound/67709,PubChem,FC(F)(F)CI,Train,1,2702,training
-"EU_REACH:
-triethoxy(2,4,4-trimethylpentyl)silane",,35435-21-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16000/7/4/2/?documentUUID=9b71a814-62b8-4353-9cb5-1b0c393adc74,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](CC(C)CC(C)(C)C)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/169694,PubChem,CCO[Si](CC(C)CC(C)(C)C)(OCC)OCC,Train,1,2702,training
-"NZ_CCID:
-2,2,2-Trifluoroacetamide",,354-38-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/893D40E5-A8DE-4877-B155-D400CB4DA8A1,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,C(=O)(C(F)(F)F)N,https://pubchem.ncbi.nlm.nih.gov/compound/67717,PubChem,NC(=O)C(F)(F)F,Train,1,2702,training
-"US_HSDB:
-Perfluoro-n-hexane",,355-42-0,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/7871,,,US_HSDB,1,C(C(C(C(F)(F)F)(F)F)(F)F)(C(C(F)(F)F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/9639,PubChem,FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train,1,2702,training
-"US_HSDB:
-Perfluorohexanesulfonic acid",,355-46-4,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8274,,,US_HSDB,1,C(C(C(C(F)(F)S(=O)(=O)O)(F)F)(F)F)(C(C(F)(F)F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/67734,PubChem,O=S(=O)(O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train,1,2702,training
-"NZ_CCID:
-2,2,3,3,4,4,5,5-Octafluoro-1-pentanol",,355-80-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4D4CCBA6-2DC7-490A-909A-493A1A51AE46,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(C(C(C(C(F)F)(F)F)(F)F)(F)F)O,https://pubchem.ncbi.nlm.nih.gov/compound/9641,PubChem,OCC(F)(F)C(F)(F)C(F)(F)C(F)F,Train,1,2702,training
-"EU_REACH:
-trifluoromethanesulphonic anhydride
-
-KR_NCIS:
-Trifluoromethanesulfonic anhydride
-
-NZ_CCID:
-Trifluoromethanesulphonic anhydride","NZ_CCID:
-trifluoromethanesulfonic anhydride",358-23-6,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22478/7/4/2/?documentUUID=1774eb89-93b1-43c9-b3ca-cd9e1253c6cf
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F56F8554-69A5-484E-9820-35FCF0962A3B","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 35 [Company Data]
-Eye Irritation
-R PHRASE: R 35 [Company Data]",Provided,"EU_REACH, KR_NCIS, NZ_CCID",3,C(F)(F)(F)S(=O)(=O)OS(=O)(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/67749,PubChem,O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F,Train,1,2702,training
-"EU_REACH:
-[2-(hydroxymethoxy)ethoxy]methanol",,3586-55-8,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19636/7/4/2/?documentUUID=0aaf6190-ec1c-4179-ba54-89c7c7b397aa,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(COCO)OCO,https://pubchem.ncbi.nlm.nih.gov/compound/62511,PubChem,OCOCCOCO,Train,1,2702,training
-"EU_CLP:
-2-bromo-1-(2-furyl)-2-nitroethylene",,35950-52-8,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=COC(=C1)/C=C(\[N+](=O)[O-])/Br,https://pubchem.ncbi.nlm.nih.gov/compound/11830903,PubChem,O=[N+]([O-])/C(Br)=C\c1ccco1,Test,1,2702,training
-"EU_REACH:
-1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione",,36062-04-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7283/7/4/2/?documentUUID=457fb42d-ef90-43cc-b95b-19142f1ca459,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=C(C=CC(=C1)CCC(=O)CC(=O)CCC2=CC(=C(C=C2)O)OC)O,https://pubchem.ncbi.nlm.nih.gov/compound/124072,PubChem,COc1cc(CCC(=O)CC(=O)CCc2ccc(O)c(OC)c2)ccc1O,Train,1,2702,training
-"EU_REACH:
-ethyl 1-[2-(2,4-dichlorophenyl)acetoxy]cyclohexanecarboxylate",,361366-16-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7292/7/4/2/?documentUUID=a9b896eb-eca5-4aa1-9114-555b62324b70,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1(CCCCC1)OC(=O)CC2=C(C=C(C=C2)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/22894816,PubChem,CCOC(=O)C1(OC(=O)Cc2ccc(Cl)cc2Cl)CCCCC1,Train,1,2702,training
-"EU_REACH:
-2-{[2-(acetyloxy)ethyl]({4-[ (E)-2-(2-bromo-4,6-dinitrophenyl)diazen-1-yl]-5acetamido-2-methoxyphenyl})amino}ethyl acetate",,3618-72-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17330/7/4/2/?documentUUID=d9905401-7742-4d05-a9b2-f328c3d3a4ef,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)NC1=CC(=C(C=C1N=NC2=C(C=C(C=C2Br)[N+](=O)[O-])[N+](=O)[O-])OC)N(CCOC(=O)C)CCOC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/77172,PubChem,COc1cc(N=Nc2c(Br)cc([N+](=O)[O-])cc2[N+](=O)[O-])c(NC(C)=O)cc1N(CCOC(C)=O)CCOC(C)=O,Train,1,2702,training
-"EU_REACH:
-({5-acetamido-4-[(2-chloro-4,6-dinitrophenyl)diazenyl]-2-methoxyphenyl}imino)diethane-2,1-diyl diacetate",,3618-73-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18576/7/4/2/?documentUUID=87dfa8c7-47dd-4ec3-876f-1c47ebcb757b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)NC1=CC(=C(C=C1N=NC2=C(C=C(C=C2Cl)[N+](=O)[O-])[N+](=O)[O-])OC)N(CCOC(=O)C)CCOC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/77173,PubChem,COc1cc(N=Nc2c(Cl)cc([N+](=O)[O-])cc2[N+](=O)[O-])c(NC(C)=O)cc1N(CCOC(C)=O)CCOC(C)=O,Train,1,2702,training
-"EU_REACH:
-N-butylbenzenesulfonamide",,3622-84-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13402/7/4/2/?documentUUID=103c0bc0-a4f3-4ee8-b901-cf33a3229dc3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCNS(=O)(=O)C1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/19241,PubChem,CCCCNS(=O)(=O)c1ccccc1,Train,1,2702,training
-"EU_REACH:
-1,4-Dihydroxy-2,2,6,6-tetramethylpiperidine",,3637-10-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16531/7/4/2/?documentUUID=dc4c0dab-62e6-4ee2-bced-7df2521e2a56,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(CC(CC(N1O)(C)C)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/5395,PubChem,CC1(C)CC(O)CC(C)(C)N1O,Train,1,2702,training
-"EU_CLP:
-(S)-(-)-2-acetoxypropionylchloride; (1S)-2-chloro-1-methyl-2-oxoethyl acetate",,36394-75-9,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C[C@@H](C(=O)Cl)OC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/11094804,PubChem,CC(=O)O[C@@H](C)C(=O)Cl,Test,1,2702,training
-"EU_REACH:
-3-(-lambda5-diazynylidene)-4-oxo-3,4-dihydronaphthalene-1-sulfonyl chloride",,36451-09-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27336/7/4/2/?documentUUID=2f8dc1bf-4f81-4f1c-a7bf-b9927039c8f9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,Cl[S](=O)(=O)C1=CC(=[N+]=[N-])C(=O)c2ccccc12,https://cactus.nci.nih.gov/chemical/structure/36451-09-9/smiles,CACTUS,[N-]=[N+]=C1C=C(S(=O)(=O)Cl)c2ccccc2C1=O,Train,1,2702,training
-"NZ_CCID:
-2-Fluorophenol",,367-12-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FE4B1FB6-36A3-42BD-BB82-7B55E6A9AAAD,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)O)F,https://pubchem.ncbi.nlm.nih.gov/compound/9707,PubChem,Oc1ccccc1F,Train,1,2702,training
-"EU_REACH:
-3-chloro-4-fluoroaniline",,367-21-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24633/7/4/2/?documentUUID=08781fe6-c742-46fe-8725-65482f5918c4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C=C1N)Cl)F,https://pubchem.ncbi.nlm.nih.gov/compound/9708,PubChem,Nc1ccc(F)c(Cl)c1,Train,1,2702,training
-"NZ_CCID:
-Propanoic acid, 2,3-dichloro-, methyl ester",,3674-09-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9074786B-5072-4C50-A939-2D0D7BC2E5F9,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41[CHEMWATCH]",,NZ_CCID,1,COC(=O)C(CCl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/95429,PubChem,COC(=O)C(Cl)CCl,Train,1,2702,training
-"NZ_CCID:
-1,1,1-Trifluoro-2,4-pentanedione",,367-57-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1F9FC6B6-7181-4AC7-8C84-115F8C5437B3,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(=O)CC(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/73943,PubChem,CC(=O)CC(=O)C(F)(F)F,Train,1,2702,training
-"NZ_CCID:
-4-Amino-2,2,6,6-tetramethylpiperidine",,36768-62-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C04A6780-6DBF-4A33-B19E-C212015AA8C9,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC1(CC(CC(N1)(C)C)N)C,https://pubchem.ncbi.nlm.nih.gov/compound/37524,PubChem,CC1(C)CC(N)CC(C)(C)N1,Train,1,2702,training
-"EU_REACH:
-(Z)-hex-3-enyl acetate",,3681-71-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12829/7/4/2/?documentUUID=29322a10-8fb1-485f-b6ab-a7ad07a2973c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC/C=C\CCOC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/5363388,PubChem,CC/C=C\CCOC(C)=O,Train,1,2702,training
-"EU_CLP:
-(E)-3,7-dimethyl-2,6-octadienylhexadecanoate",,3681-73-0,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCCCCCCCCCCCCCCC(=O)OC/C=C(\C)/CCC=C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11246350,PubChem,CCCCCCCCCCCCCCCC(=O)OC/C=C(\C)CCC=C(C)C,Test,1,2702,training
-"NZ_CCID:
-3-(Trifluoromethyl)-benzonitrile","NZ_CCID:
-3-(trifluoromethyl)benzonitrile",368-77-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5F224D94-7CBE-4B45-8D74-C05C4F34470D,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)C(F)(F)F)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/67783,PubChem,N#Cc1cccc(C(F)(F)F)c1,Train,1,2702,training
-"JP_CHRIP:
-sulfotep","JP_CHRIP:
-Ethyl thiopyrophosphate
-O,O,O',O'-Tetraethyl oxybis(thiophosphonate)
-Tetraethyl dithiopyrophosphate (TEDP)
-Thiodiphosphoric acid ([(HO)2P(S)]2O), tetraethyl ester
-Thiodiphosphoric acid tetraethyl ester",3689-24-5,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0678e.html,"JP_CHRIP:
-There are results that skin irritation was not observed on rabbit (ACGIH and (2005), DFGOT vol.13 (1999), and PATTY (5th, 2001)), however, there are many descriptions on humans that it stimulates skin and causes disorder (ACGIH (2005), ICSC (J), (1999), HSDB (2005), HSFS (2000), SITTIG (2002)). Since there was no statement about the disorder and concrete description or a grade of the stimulativeness on humans, taking the larger side with danger, it was classified as Category 2.",,JP_CHRIP,1,CCOP(=S)(OCC)OP(=S)(OCC)OCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J86.052B,J-GLOBAL,CCOP(=S)(OCC)OP(=S)(OCC)OCC,Train,1,2702,training
-"NZ_CCID:
-4-Fluorophenol",,371-41-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/ED783F84-DAC1-4A28-BC76-CF74D976341A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1O)F,https://pubchem.ncbi.nlm.nih.gov/compound/9732,PubChem,Oc1ccc(F)cc1,Train,1,2702,training
-"EU_CLP:
-1-methoxy-2-propylamine",,37143-54-7,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(COC)N,https://pubchem.ncbi.nlm.nih.gov/compound/123458,PubChem,COCC(C)N,Test,1,2702,training
-"NZ_CCID:
-2-Pentanone, 4-methyl-, peroxide, ≤62%","NZ_CCID:
-Methyl isoButyl ketone peroxide",37206-20-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2F23B09F-B5C4-4C32-A3A8-63EFDF63E941,"NZ_CCID:
-Skin Irritation
-SPECIES:
-RESULT: Very severe irritant
-REFERENCE SOURCE: [PATTYS]
-Eye Irritation
-SPECIES:
-RESULT: Severe irritant
-REFERENCE SOURCE: [PATTYS]",,NZ_CCID,1,CC(=O)CC(C)(C)OO,https://pubchem.ncbi.nlm.nih.gov/compound/119804,PubChem,CC(=O)CC(C)(C)OO,Train,1,2702,training
-"EU_REACH:
-2,2',2''-Nitrilotriethanol, propoxylated",,37208-53-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14569/7/4/2/?documentUUID=8c8735d2-7058-44ed-aeec-1f1449d0ed45,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CO)OCC(C)OCC(C)OCCN(CCOCC(C)OCC(C)OCC(C)O)CCOCC(C)OCC(C)OCC(C)O,https://pubchem.ncbi.nlm.nih.gov/compound/73555758,PubChem,CC(O)COC(C)COC(C)COCCN(CCOCC(C)OCC(C)OCC(C)O)CCOC(C)COC(C)COC(C)CO,Train,1,2702,training
-"NZ_CCID:
-Cyanoacetic acid",,372-09-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1226DFFA-F378-4188-8410-540F188842D9,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(C#N)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/9740,PubChem,N#CCC(=O)O,Train,1,2702,training
-"NZ_CCID:
-3-Fluoroaniline",,372-19-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6F3681B8-D80C-4D1E-BCBA-B053D7483236,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)F)N,https://pubchem.ncbi.nlm.nih.gov/compound/9742,PubChem,Nc1cccc(F)c1,Train,1,2702,training
-"NZ_CCID:
-Cyclobutanecarboxylic acid",,3721-95-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C010E7EF-272F-4AE9-A9F6-FA7B0561D4DE,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CC(C1)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/19494,PubChem,O=C(O)C1CCC1,Train,1,2702,training
-"NZ_CCID:
-3-Fluorophenol",,372-20-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1C6901A4-C831-48CD-BADE-5AF12618E531,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)F)O,https://pubchem.ncbi.nlm.nih.gov/compound/9743,PubChem,Oc1cccc(F)c1,Train,1,2702,training
-"JP_CHRIP:
-Crotonic acid
-
-NZ_CCID:
-Crotonic acid","JP_CHRIP:
-2-Butenoic acid
-3-Methylacrylic acid
-alpha-Crotonic acid
-beta-Methylacrylic acid
-trans-2-Butenoic acid",3724-65-0,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0137e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EBF37755-6D59-4E55-9B03-7C2055C8A1B4","JP_CHRIP:
-The substance was classified as Category 2 based on the documented case of ""strong irritant"" (PATTY, 5th (2001)) resulted from the test in which 100 mg of the undiluted test substance was applied to rabbit or guinea pig.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,"JP_CHRIP, NZ_CCID",2,CC=CC(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J109.464E,J-GLOBAL,CC=CC(=O)O,Train,1,2702,training
-"NZ_CCID:
-2-(Aminomethyl) pyridine",,3731-51-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/854629E5-CDCC-43A2-835C-3C7B9FA54697,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=NC(=C1)CN,https://pubchem.ncbi.nlm.nih.gov/compound/19509,PubChem,NCc1ccccn1,Train,1,2702,training
-"NZ_CCID:
-3-(Aminomethyl) pyridine",,3731-52-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7606FA3E-BC61-4BE1-B81D-AFB7B6E55B10,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CN=C1)CN,https://pubchem.ncbi.nlm.nih.gov/compound/31018,PubChem,NCc1cccnc1,Train,1,2702,training
-"NZ_CCID:
-1,8-Diaminooctane",,373-44-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D948E290-2614-409A-A9DE-69415D4C9FF8,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(CCCCN)CCCN,https://pubchem.ncbi.nlm.nih.gov/compound/24250,PubChem,NCCCCCCCCN,Train,1,2702,training
-"NZ_CCID:
-Heptafluorobutyryl chloride",,375-16-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D9791ECB-F0B3-403A-BC26-911ABF08236C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(=O)(C(C(C(F)(F)F)(F)F)(F)F)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/67810,PubChem,O=C(Cl)C(F)(F)C(F)(F)C(F)(F)F,Train,1,2702,training
-"NZ_CCID:
-Perfluorobutyric acid","NZ_CCID:
-Butanoic acid, heptafluoro-",375-22-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/80DB4B3B-54C4-4A8E-AA90-E45D838D3CFC,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C(=O)(C(C(C(F)(F)F)(F)F)(F)F)O,https://pubchem.ncbi.nlm.nih.gov/compound/9777,PubChem,O=C(O)C(F)(F)C(F)(F)C(F)(F)F,Train,1,2702,training
-"EU_REACH:
-4,4'-bis(methoxymethyl)-1,1'-biphenyl",,3753-18-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1633/7/4/2/?documentUUID=15be8d1e-2fb8-434c-9f41-14a96d5631fd,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COCC1=CC=C(C=C1)C2=CC=C(C=C2)COC,https://pubchem.ncbi.nlm.nih.gov/compound/1519430,PubChem,COCc1ccc(-c2ccc(COC)cc2)cc1,Train,1,2702,training
-"US_HSDB:
-Perfluorobutanesulfonic acid",,375-73-5,Cat 1,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8294,,,US_HSDB,1,C(C(C(F)(F)S(=O)(=O)O)(F)F)(C(F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/67815,PubChem,O=S(=O)(O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train,1,2702,training
-"US_HSDB:
-Perfluoroheptanoic acid",,375-85-9,Cat 1,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8293,,,US_HSDB,1,C(=O)(C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)O,https://pubchem.ncbi.nlm.nih.gov/compound/67818,PubChem,O=C(O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train,1,2702,training
-"EU_REACH:
-5-cyclohexadecen-1-one",,37609-25-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19655/7/4/2/?documentUUID=96719c40-821a-4f0a-9d8c-2c9abe420638,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CCCCCC(=O)CCCC=CCCCC1,https://pubchem.ncbi.nlm.nih.gov/compound/162268,PubChem,O=C1CCCC=CCCCCCCCCCC1,Train,1,2702,training
-"EU_REACH:
-{bis[(butan-2-yl)amino](methyl)silyl}(butan-2-yl)amine",,37697-65-7,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23673/7/4/2/?documentUUID=c41b50ae-33e3-451d-bb29-d6e76d257b32,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)N[Si](C)(NC(C)CC)NC(C)CC,https://pubchem.ncbi.nlm.nih.gov/compound/169958,PubChem,CCC(C)N[Si](C)(NC(C)CC)NC(C)CC,Train,1,2702,training
-"EU_REACH:
-6-(-lambda5-diazynylidene)-5-oxo-5,6-dihydronaphthalene-2-sulfonyl chloride",,3770-97-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27752/7/4/2/?documentUUID=47012ac2-fb09-4da4-b258-97a21f657d6a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=C(C=CC(=C2[O-])[N+]#N)C(=C1)S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/107462,PubChem,N#[N+]c1ccc2c(S(=O)(=O)Cl)cccc2c1[O-],Train,1,2702,training
-"EU_REACH:
-methyl (2R)-2-amino-2-(4-hydroxyphenyl)acetate",,37763-23-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10444/7/4/2/?documentUUID=d829d5af-76dd-4278-b509-5e68cb66433a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)[C@@H](C1=CC=C(C=C1)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/11298312,PubChem,COC(=O)[C@H](N)c1ccc(O)cc1,Train,1,2702,training
-"NZ_CCID:
-Dichlormid","NZ_CCID:
-2,2-Dichloro-N,N-di-2-propenylacetamide, Acetamide, 2,2-dichloro-N,N-di-2-propenyl-, N,N-Diallyl-2,2-dichloroacetamide, N,N-Diallyldichloroacetamide",37764-25-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A53570F8-5366-46B8-BF1B-EDDE3D68BC08,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 38. [PESTICIDES MANUAL 12 ED]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Slightly irritating to eyes.
-REFERENCE SOURCE: [PESTICIDES MANUAL 12 ED]",,NZ_CCID,1,C=CCN(CC=C)C(=O)C(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/37829,PubChem,C=CCN(CC=C)C(=O)C(Cl)Cl,Train,1,2702,training
-"EU_REACH:
-(4E,9E)-4,7,10-trimethyl-7-{[(E)-(pentan-2-ylidene)amino]oxy}-6,8-dioxa-5,9-diaza-7-silatrideca-4,9-diene",,37859-55-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10483/7/4/2/?documentUUID=f9709787-7856-428f-b71b-68a0be09b8df,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC/C(=N/O[Si](O/N=C(/CCC)\C)(O/N=C(/CCC)\C)C)/C,https://pubchem.ncbi.nlm.nih.gov/compound/154734426,PubChem,CCC/C(C)=N/O[Si](C)(O/N=C(\C)CCC)O/N=C(\C)CCC,Train,1,2702,training
-"EU_REACH:
-(1S)-1-phenylpropan-1-amine",,3789-59-1,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12413/7/4/2/?documentUUID=8808eb0c-2c67-4bb0-9fae-fbace9c85f10,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC[C@@H](C1=CC=CC=C1)N,https://pubchem.ncbi.nlm.nih.gov/compound/6993773,PubChem,CC[C@H](N)c1ccccc1,Test,1,2702,training
-"EU_REACH:
-2,2-bis(chloromethyl)propane-1,3-diyl tetrakis(2-chloroethyl) bis(phosphate)",,38051-10-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13748/7/4/2/?documentUUID=648831a0-0465-4977-bfbb-069db6af8927,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CCl)OP(=O)(OCCCl)OCC(COP(=O)(OCCCl)OCCCl)(CCl)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/92310,PubChem,O=P(OCCCl)(OCCCl)OCC(CCl)(CCl)COP(=O)(OCCCl)OCCCl,Train,1,2702,training
-"NZ_CCID:
-cis, cis 1,3-Cyclooctadiene",,3806-59-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9421699B-3FD2-4683-8E52-0EBA6814D365,"NZ_CCID:
-Skin Irritation
-REMARK: Refer to classification of CAS 111-78-4.
-Eye Irritation
-REMARK: Refer to classification of CAS 111-78-4.",,NZ_CCID,1,C1C/C=C\C=C/CC1,https://pubchem.ncbi.nlm.nih.gov/compound/299882,PubChem,C1=C\CCCC\C=C/1,Train,1,2702,training
-"EU_CLP:
-benazolin (ISO); 4-chloro-2,3-dihydro-2-oxo-1,3-benzothiazol-3-ylacetic acid",,3813-05-6,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC2=C(C(=C1)Cl)N(C(=O)S2)CC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/19662,PubChem,O=C(O)Cn1c(=O)sc2cccc(Cl)c21,Test,1,2702,training
-"JP_CHRIP:
-Difluoroacetic acid",,381-73-7,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-0022e.html,"JP_CHRIP:
-[Rationale for the Classification]
-Based on (1), since this substance was a strong acid (pH <= 2), it was classified in Category 1 in accordance with the GHS Classification Guidance for the Japanese Government.
-
-[Evidence Data]
-(1) The measured pH value of this substance (1% solution) was 1.28 (24 deg C), which corresponded to a strong acid (pH <= 2) (REACH registration dossier (Access on November 2019)).",,JP_CHRIP,1,OC(=O)C(F)F,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J54.208C,J-GLOBAL,O=C(O)C(F)F,Train,1,2702,training
-"AU_HCIS:
-Silane, dichloromethyl(3,3,4,4,5,5,6,6,6-nonafluorohexyl)-",,38436-16-7,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6554,,,AU_HCIS,1,C[Si](CCC(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/2776177,PubChem,C[Si](Cl)(Cl)CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train,1,2702,training
-"EU_CLP:
-3-chloro-2,4-difluoronitrobenzene",,3847-58-3,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC(=C(C(=C1[N+](=O)[O-])F)Cl)F,https://pubchem.ncbi.nlm.nih.gov/compound/223080,PubChem,O=[N+]([O-])c1ccc(F)c(Cl)c1F,Test,1,2702,training
-"EU_REACH:
-ethyl cyano(hydroxyimino)acetate",,3849-21-6,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19974/7/4/2/?documentUUID=cae8e6d5-7340-4d92-8bfc-18cad6cf6cbf,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)/C(=N/O)/C#N,https://pubchem.ncbi.nlm.nih.gov/compound/6400537,PubChem,CCOC(=O)/C(C#N)=N/O,Train,1,2702,training
-"EU_CLP:
-2,3,4-trifluoroaniline",,3862-73-5,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC(=C(C(=C1N)F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/77468,PubChem,Nc1ccc(F)c(F)c1F,Test,1,2702,training
-"EU_REACH:
-1,3-bis(isocyanatomethyl)cyclohexane",,38661-72-2,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27064/7/4/2/?documentUUID=b1295745-8ea6-4725-934d-a56d8c18ecdc,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC(CC(C1)CN=C=O)CN=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/53172,PubChem,O=C=NCC1CCCC(CN=C=O)C1,Train,1,2702,training
-"NZ_CCID:
-Octadecanamide, N,N-dimethyl-",,3886-90-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/307264BC-968E-46BC-8B34-52A3AA0E91F0,,,NZ_CCID,1,CCCCCCCCCCCCCCCCCC(=O)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/19765,PubChem,CCCCCCCCCCCCCCCCCC(=O)N(C)C,Train,1,2702,training
-"EU_REACH:
-(1-ethoxyethoxy)cyclododecane",,389083-83-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27298/7/4/2/?documentUUID=b2d182c8-f4db-48bd-9802-7b287ba402c7,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(C)OC1CCCCCCCCCCC1,https://pubchem.ncbi.nlm.nih.gov/compound/22717736,PubChem,CCOC(C)OC1CCCCCCCCCCC1,Train,1,2702,training
-"EU_REACH:
-Ethanone, 2-​chloro-​1-​(3-​chloro-​4-​hydroxyphenyl)​-",,39066-18-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17995/7/4/2/?documentUUID=ceaec4d9-48ba-4ce8-a2a5-dbeb5c3659fd,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C=C1C(=O)CCl)Cl)O,https://pubchem.ncbi.nlm.nih.gov/compound/23191752,PubChem,O=C(CCl)c1ccc(O)c(Cl)c1,Test,1,2702,training
-"EU_REACH:
-3,5-dimethoxy-4-propoxybenzaldehyde",,39075-26-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30813/7/4/2/?documentUUID=1d1e731a-fa0c-4f1f-9bcd-112dbf2c6210,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCOC1=C(C=C(C=C1OC)C=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/4771124,PubChem,CCCOc1c(OC)cc(C=O)cc1OC,Train,1,2702,training
-"EU_REACH:
-2-butyloctan-1-ol",,3913-02-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11955/7/4/2/?documentUUID=2d336c1f-d89c-43b2-b449-e5793536114d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCC(CCCC)CO,https://pubchem.ncbi.nlm.nih.gov/compound/19800,PubChem,CCCCCCC(CO)CCCC,Train,1,2702,training
-"NZ_CCID:
-2-Fluorobenzoyl chloride",,393-52-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/92A2E229-5C95-405C-91A5-17D2D3F29D79,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)C(=O)Cl)F,https://pubchem.ncbi.nlm.nih.gov/compound/9808,PubChem,O=C(Cl)c1ccccc1F,Train,1,2702,training
-"EU_REACH:
-5-Fluoro-2-nitrobenzoic acid methyl ester",,393-85-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10865/7/4/2/?documentUUID=d10141ce-b662-4e1e-8f7a-9cb13c89214e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=C(C=CC(=C1)F)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/5152049,PubChem,COC(=O)c1cc(F)ccc1[N+](=O)[O-],Train,1,2702,training
-"NZ_CCID:
-1-Octanesulphonic acid",,3944-72-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C0AFB335-8E2D-4ED2-A082-7615B18BB3FE,,,NZ_CCID,1,CCCCCCCCS(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/49939,PubChem,CCCCCCCCS(=O)(=O)O,Train,1,2702,training
-"AU_HCIS:
-Hexadecanamide, N-[3-(dimethylamino)propyl]-",,39669-97-1,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6764,,,AU_HCIS,1,CCCCCCCCCCCCCCCC(=O)NCCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/38313,PubChem,CCCCCCCCCCCCCCCC(=O)NCCCN(C)C,Train,1,2702,training
-"EU_REACH:
-2-[2-(2-ethoxyethoxy)ethoxy]ethyl methacrylate",,39670-09-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15995/7/4/2/?documentUUID=84f3f95c-4c67-49c3-bb9f-730fc70a29d4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOCCOCCOCCOC(=O)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/162388,PubChem,C=C(C)C(=O)OCCOCCOCCOCC,Train,1,2702,training
-"NZ_CCID:
-4-Bromo-t-butylbenzene","NZ_CCID:
-1-bromo-4-tert-butylbenzene",3972-65-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7E19DCC5-4D9D-457E-96B9-4C58F20248AC,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(C)(C)C1=CC=C(C=C1)Br,https://pubchem.ncbi.nlm.nih.gov/compound/77595,PubChem,CC(C)(C)c1ccc(Br)cc1,Train,1,2702,training
-"EU_REACH:
-1,3,3,5-tetramethyl-1,1,5,5-tetraphenyltrisiloxane",,3982-82-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21455/7/4/2/?documentUUID=2057d42d-4d8f-4a0b-a821-326862b16a30,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](C)(O[Si](C)(C1=CC=CC=C1)C2=CC=CC=C2)O[Si](C)(C3=CC=CC=C3)C4=CC=CC=C4,https://pubchem.ncbi.nlm.nih.gov/compound/19882,PubChem,C[Si](C)(O[Si](C)(c1ccccc1)c1ccccc1)O[Si](C)(c1ccccc1)c1ccccc1,Train,1,2702,training
-"EU_REACH:
-2-amino-5-bromopyridin-3-ol",,39903-01-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10834/7/4/2/?documentUUID=c81c03ec-9928-4f91-9104-5d7bf9287668,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(C=NC(=C1O)N)Br,https://pubchem.ncbi.nlm.nih.gov/compound/11694041,PubChem,Nc1ncc(Br)cc1O,Train,1,2702,training
-"EU_REACH:
-3-(2-chlorophenyl)-3-oxopropanenitrile",,40018-25-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15696/7/4/2/?documentUUID=cb352bfe-b57e-45bb-94c7-0108401cf9cf,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=C1)C(=O)CC#N)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/2734201,PubChem,N#CCC(=O)c1ccccc1Cl,Train,1,2702,training
-"EU_REACH:
-(3S)-1,3,4-trihydroxybutan-2-one",,40031-31-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30699/7/4/2/?documentUUID=4eddc958-cb03-4623-8c1f-a19cc7ad4662,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(C(C(=O)CO)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/162406,PubChem,O=C(CO)C(O)CO,Train,1,2702,training
-"JP_CHRIP:
-2,3-epoxypropyl isopropyl ether","JP_CHRIP:
-(Isopropoxymethyl)oxirane
-1,2-Epoxy-3-isopropoxypropane
-IGE
-Oxirane, [(1-methylethoxy)methyl]-",4016-14-2,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0668e.html,"JP_CHRIP:
-It was classified as Category 2 based on the report that moderate skin irritation was observed on rabbits (PATTY (5th, 2001)).",,JP_CHRIP,1,CC(C)OCC1CO1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J35.468F,J-GLOBAL,CC(C)OCC1CO1,Train,1,2702,training
-"AU_HCIS:
-9-Octadecen-1-amine, N-9-octadecenyl-, (Z,Z)-",,40165-68-2,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5777,,,AU_HCIS,1,CCCCCCCC/C=C\CCCCCCCCNCCCCCCCC/C=C\CCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/11214516,PubChem,CCCCCCCC/C=C\CCCCCCCCNCCCCCCCC/C=C\CCCCCCCC,Train,1,2702,training
-"EU_CLP:
-3,7-dimethyloctanenitrile",,40188-41-8,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C)CCCC(C)CC#N,https://pubchem.ncbi.nlm.nih.gov/compound/170284,PubChem,CC(C)CCCC(C)CC#N,Test,1,2702,training
-"NZ_CCID:
-Cyclopropanecarboxylic acid chloride",,4023-34-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C96FB264-DFA8-47DF-AF07-F28A8EF37C7D,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CC1C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/77637,PubChem,O=C(Cl)C1CC1,Train,1,2702,training
-"NZ_CCID:
-4-Hydroxybenzotrifluoride",,402-45-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3B073150-63FE-4E16-9848-432A4DCFF2EC,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1C(F)(F)F)O,https://pubchem.ncbi.nlm.nih.gov/compound/67874,PubChem,Oc1ccc(C(F)(F)F)cc1,Train,1,2702,training
-"EU_CLP:
-neodecanoyl chloride",,40292-82-8,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C)(C)CCCCCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/94502,PubChem,CC(C)(C)CCCCCC(=O)Cl,Test,1,2702,training
-"NZ_CCID:
-4-Fluorobenzoyl chloride",,403-43-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/49543CF3-41D7-4AF0-A984-01B536578800,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1C(=O)Cl)F,https://pubchem.ncbi.nlm.nih.gov/compound/67879,PubChem,O=C(Cl)c1ccc(F)cc1,Train,1,2702,training
-"NZ_CCID:
-Imidodicarbonic diamide, N,N',2-tris(6-isocyanatohexyl)-, >10% in a non hazardous diluent",,4035-89-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D594939A-5F67-4BBE-A5DF-AD519C8787CB,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,C(CCCN=C=O)CCNC(=O)N(CCCCCCN=C=O)C(=O)NCCCCCCN=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/19950,PubChem,O=C=NCCCCCCNC(=O)N(CCCCCCN=C=O)C(=O)NCCCCCCN=C=O,Train,1,2702,training
-"NZ_CCID:
-Benzene, 1,4-diisothiocyanato-",,4044-65-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/24E5BE65-2528-4353-88C3-5FEC74CB0AD5,,,NZ_CCID,1,C1=CC(=CC=C1N=C=S)N=C=S,https://pubchem.ncbi.nlm.nih.gov/compound/19958,PubChem,S=C=Nc1ccc(N=C=S)cc1,Train,1,2702,training
-"NZ_CCID:
-6-Nonenamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methyl-, (6E)-
-
-US_HSDB:
-CAPSAICIN","NZ_CCID:
-(E)-capsaicin, Capsaicin",404-86-4,Cat 2,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8AFEA4CE-2DE3-4D2A-B1B1-09C9B98A2D39
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/954","NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,"NZ_CCID, US_HSDB",2,CC(C)/C=C/CCCCC(=O)NCC1=CC(=C(C=C1)O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/1548943,PubChem,COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O,Train,1,2702,training
-"EU_REACH:
-2-[(1-amino-4-hydroxy-9,10-dioxo-9,10-dihydroanthracen-2-yl)oxy]ethyl ethyl carbonate",,40530-60-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10046/7/4/2/?documentUUID=38991f8c-b90f-4718-a130-d2074deafaaa,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)OCCOC1=C(C2=C(C(=C1)O)C(=O)C3=CC=CC=C3C2=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/162415,PubChem,CCOC(=O)OCCOc1cc(O)c2c(c1N)C(=O)c1ccccc1C2=O,Train,1,2702,training
-"EU_REACH:
-1,1,2,2,3,3-hexafluoro-1-[(1,2,2-trifluoroethenyl)oxy]-3-(trifluoromethoxy)propane",,40573-09-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27489/7/4/2/?documentUUID=d761f6ea-bee3-464f-bc06-4d85acd847d9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(=C(F)F)(OC(C(C(OC(F)(F)F)(F)F)(F)F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/22613616,PubChem,FC(F)=C(F)OC(F)(F)C(F)(F)C(F)(F)OC(F)(F)F,Train,1,2702,training
-"US_HSDB:
-METHOPRENE",,40596-69-8,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/6926,,,US_HSDB,1,CC(C)OC(=O)/C=C(\C)/C=C/CC(C)CCCC(C)(C)OC,https://pubchem.ncbi.nlm.nih.gov/compound/5366546,PubChem,COC(C)(C)CCCC(C)C/C=C/C(C)=C/C(=O)OC(C)C,Train,1,2702,training
-"EU_REACH:
-tris[(4-tert-butyl-3-hydroxy-2,6-dimethylphenyl)methyl]-1,3,5-triazinane-2,4,6-trione",,40601-76-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13735/7/4/2/?documentUUID=d7ddc148-91ca-407b-8078-9a5f59de4f1b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C(=C1CN2C(=O)N(C(=O)N(C2=O)CC3=C(C(=C(C=C3C)C(C)(C)C)O)C)CC4=C(C(=C(C=C4C)C(C)(C)C)O)C)C)O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/93221,PubChem,Cc1cc(C(C)(C)C)c(O)c(C)c1Cn1c(=O)n(Cc2c(C)cc(C(C)(C)C)c(O)c2C)c(=O)n(Cc2c(C)cc(C(C)(C)C)c(O)c2C)c1=O,Train,1,2702,training
-"EU_REACH:
-N,N'-(2,5-dichloro-1,4-phenylene)bis{4-[(2,5-dichlorophenyl)diazenyl]-3-hydroxy-2-naphthamide}",,40618-31-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5670/7/4/2/?documentUUID=e82fd8bc-16fb-41e2-b860-5563b21cb592,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C=C(C(=C2N=NC3=C(C=CC(=C3)Cl)Cl)O)C(=O)NC4=CC(=C(C=C4Cl)NC(=O)C5=CC6=CC=CC=C6C(=C5O)N=NC7=C(C=CC(=C7)Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/162420,PubChem,O=C(Nc1cc(Cl)c(NC(=O)c2cc3ccccc3c(N=Nc3cc(Cl)ccc3Cl)c2O)cc1Cl)c1cc2ccccc2c(N=Nc2cc(Cl)ccc2Cl)c1O,Train,1,2702,training
-"EU_CLP:
-2-ethyl-N-methyl-N-(3-methylphenyl)butanamide",,406488-30-0,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCC(CC)C(=O)N(C)C1=CC=CC(=C1)C,https://pubchem.ncbi.nlm.nih.gov/compound/57495095,PubChem,CCC(CC)C(=O)N(C)c1cccc(C)c1,Test,1,2702,training
-"EU_CLP:
-4-propylcyclohexanone",,40649-36-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCCC1CCC(=O)CC1,https://pubchem.ncbi.nlm.nih.gov/compound/142482,PubChem,CCCC1CCC(=O)CC1,Test,1,2702,training
-"KR_NCIS:
-3,6,9,12-Tetraazatetradecane-1,14-diamine; 3,6,9,12-Tetraazatetradecamethylenediamine",,4067-16-7,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C(CNCCNCCNCCNCCN)N,https://pubchem.ncbi.nlm.nih.gov/compound/19990,PubChem,NCCNCCNCCNCCNCCN,Train,1,2702,training
-"EU_REACH:
-2-[(2-cyanoethyl){4-[(4-nitrophenyl)diazenyl]phenyl}amino]ethyl benzoate",,40690-89-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18570/7/4/2/?documentUUID=81f52c23-74bb-473c-bdc7-30a4af3fe2e3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C(=O)OCCN(CCC#N)C2=CC=C(C=C2)N=NC3=CC=C(C=C3)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/162422,PubChem,N#CCCN(CCOC(=O)c1ccccc1)c1ccc(N=Nc2ccc([N+](=O)[O-])cc2)cc1,Train,1,2702,training
-"NZ_CCID:
-Trifluoroacetic anhydride",,407-25-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2AF261F2-7517-4FDC-B1B2-ED62348315F4,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 35 [Company Data]
-Eye Irritation
-R PHRASE: R 35 [Company Data]",,NZ_CCID,1,C(=O)(C(F)(F)F)OC(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/9845,PubChem,O=C(OC(=O)C(F)(F)F)C(F)(F)F,Train,1,2702,training
-"EU_CLP:
-2,2'-oxydiethyl diacrylate; diethylene glycol diacrylate",,4074-88-8,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C=CC(=O)OCCOCCOC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/19996,PubChem,C=CC(=O)OCCOCCOC(=O)C=C,Test,1,2702,training
-"NZ_CCID:
-2,4-Dimethyl-3-pentylamine",,4083-57-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C738A72C-BFC5-498B-A2CD-2D5EC814D321,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 34. [Chemwatch]
-Eye Irritation
-R-PHRASE: R 34/ 41. [Chemwatch]",,NZ_CCID,1,CC(C)C(C(C)C)N,https://pubchem.ncbi.nlm.nih.gov/compound/77702,PubChem,CC(C)C(N)C(C)C,Train,1,2702,training
-"AU_HCIS:
-4-isocyanatosulphonyltoluene
-
-NZ_CCID:
-4-Toluenesulphonyl isocyanate","AU_HCIS:
-tosyl isocyanate
-Benzenesulfonyl isocyanate, 4-methyl-
-4-isocyanatosulfonyltoluene
-
-NZ_CCID:
-Benzenesulfonyl isocyanate, 4-methyl-, p-Toluenesulfonic acid, anhydride with isocyanic acid, p-Toluenesulphonyl isocyanate, p-toluenesulfonyl isocyanate, tosyl isocyanate",4083-64-1,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=2660
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6CFAF146-2781-492E-A0B7-6BE98CDDF198","NZ_CCID:
-Skin Irritation
-R-PHRASE: R36/37/38 Irritating to eyes, respiratory system and skin. [N-CLASS]
-Eye Irritation
-R-PHRASE: R36/37/38 Irritating to eyes, respiratory system and skin. [N-CLASS]",,"AU_HCIS, NZ_CCID",2,CC1=CC=C(C=C1)S(=O)(=O)N=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/77703,PubChem,Cc1ccc(S(=O)(=O)N=C=O)cc1,Train,1,2702,training
-"EU_REACH:
-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide",,40908-37-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24370/7/4/2/?documentUUID=4643aa0e-e333-487d-a641-f7c1f78d09d7,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)NC1CC(NC(C1)(C)C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/100241,PubChem,CC(=O)NC1CC(C)(C)NC(C)(C)C1,Train,1,2702,training
-"EU_CLP:
-3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate; isophorone di-isocyanate",,4098-71-9,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC1(CC(CC(C1)(C)CN=C=O)N=C=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/169132,PubChem,CC1(C)CC(N=C=O)CC(C)(CN=C=O)C1,Test,1,2702,training
-"NZ_CCID:
-Dichloroacetic anhydride",,4124-30-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F9F67E6A-5DE3-4BD8-A319-9BC7E89B4E69,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(C(=O)OC(=O)C(Cl)Cl)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/77772,PubChem,O=C(OC(=O)C(Cl)Cl)C(Cl)Cl,Train,1,2702,training
-"EU_REACH:
-2-(7-ethyl-1H-indol-3-yl)ethan-1-ol",,41340-36-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22803/7/4/2/?documentUUID=b9355038-11e9-48ee-92b0-12615a0760c1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1=C2C(=CC=C1)C(=CN2)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/198231,PubChem,CCc1cccc2c(CCO)c[nH]c12,Test,1,2702,training
-"EU_REACH:
-[(3aS,4S,6S)-6-methoxy-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methyl 4-methylbenzene-1-sulfonate",,4137-56-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22244/7/4/2/?documentUUID=1606047f-bf41-4301-80e4-7e5d01fe7c7e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)S(=O)(=O)OC[C@@H]2[C@@H]3[C@H]([C@@H](O2)OC)OC(O3)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11013769,PubChem,CO[C@@H]1O[C@H](COS(=O)(=O)c2ccc(C)cc2)[C@H]2OC(C)(C)O[C@@H]12,Train,1,2702,training
-"EU_REACH:
-diethyl pyridine-2,4-dicarboxylate",,41438-38-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18795/7/4/2/?documentUUID=aeabbe4e-be2a-4a36-b770-fbb08e206fc0,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1=CC(=NC=C1)C(=O)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/170509,PubChem,CCOC(=O)c1ccnc(C(=O)OCC)c1,Test,1,2702,training
-"EU_REACH:
-N-(4-acetamidophenyl)-3-hydroxy-2-naphthamide",,41506-62-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10876/7/4/2/?documentUUID=17c92dc7-6666-430d-89d5-d149c937a522,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)NC1=CC=C(C=C1)NC(=O)C2=CC3=CC=CC=C3C=C2O,https://pubchem.ncbi.nlm.nih.gov/compound/170529,PubChem,CC(=O)Nc1ccc(NC(=O)c2cc3ccccc3cc2O)cc1,Train,1,2702,training
-"EU_REACH:
-O,O,O-tris-(4-isocyanatophenyl) thiophosphate",,4151-51-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11957/7/4/2/?documentUUID=36efab26-fd4f-4c16-85e8-557c6bbff8bc,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1N=C=O)OP(=S)(OC2=CC=C(C=C2)N=C=O)OC3=CC=C(C=C3)N=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/77798,PubChem,O=C=Nc1ccc(OP(=S)(Oc2ccc(N=C=O)cc2)Oc2ccc(N=C=O)cc2)cc1,Train,1,2702,training
-"KR_NCIS:
-1,3-Benzenedimethanethiol",,41563-69-3,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C1=CC(=CC(=C1)CS)CS,https://pubchem.ncbi.nlm.nih.gov/compound/586424,PubChem,SCc1cccc(CS)c1,Train,1,2702,training
-"NZ_CCID:
-Ethoxylated bis-phenol A dimethacrylate",,41637-38-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C26D1222-5687-46A8-A2BF-63DE4BD45D37,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,CC(=C)C(=O)OCCOc1ccc(cc1)C(C)(C)c2ccc(OCCOC(=O)C(C)=C)cc2,https://cactus.nci.nih.gov/chemical/structure/41637-38-1/smiles,CACTUS,C=C(C)C(=O)OCCOc1ccc(C(C)(C)c2ccc(OCCOC(=O)C(=C)C)cc2)cc1,Train,1,2702,training
-"EU_REACH:
-N-[2-[(2,6-dicyano-4-nitrophenyl)azo]-5-(diethylamino)phenyl]acetamide",,41642-51-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21426/7/4/2/?documentUUID=d945a5b6-992d-4a2d-ade7-70af51e74abd,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(CC)C1=CC(=C(C=C1)N=NC2=C(C=C(C=C2C#N)[N+](=O)[O-])C#N)NC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/162043,PubChem,CCN(CC)c1ccc(N=Nc2c(C#N)cc([N+](=O)[O-])cc2C#N)c(NC(C)=O)c1,Train,1,2702,training
-"EU_REACH:
-1-palmitoyl-4-(palmitoyloxy)-L-proline",,41672-81-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20945/7/4/2/?documentUUID=93dc36a1-c382-4e94-b873-1a47a9f6db21,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCC(=O)N1C[C@@H](C[C@H]1C(=O)O)OC(=O)CCCCCCCCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/170556,PubChem,CCCCCCCCCCCCCCCC(=O)O[C@@H]1C[C@@H](C(=O)O)N(C(=O)CCCCCCCCCCCCCCC)C1,Train,1,2702,training
-"EU_REACH:
-1-methoxy-4-prop-1-en-1-ylbenzene",,4180-23-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13872/7/4/2/?documentUUID=0ce5decd-35bf-4334-a897-25e5cfcc1c03,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C/C=C/C1=CC=C(C=C1)OC,https://pubchem.ncbi.nlm.nih.gov/compound/637563,PubChem,C/C=C/c1ccc(OC)cc1,Train,1,2702,training
-"EU_CLP:
-1-(chlorophenylmethyl)-2-methylbenzene",,41870-52-4,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC1=CC=CC=C1C(C2=CC=CC=C2)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10798787,PubChem,Cc1ccccc1C(Cl)c1ccccc1,Test,1,2702,training
-"EU_REACH:
-4-Hydroxy-3,5-dimethylbenzonitrile",,4198-90-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25959/7/4/2/?documentUUID=43ef3744-6738-4b1a-8566-cdb7a8272fcb,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=CC(=C1O)C)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/20176,PubChem,Cc1cc(C#N)cc(C)c1O,Train,1,2702,training
-"EU_REACH:
-4-tert-butylbenzonitrile",,4210-32-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10650/7/4/2/?documentUUID=dc982657-d4a8-4cf5-8e17-ae39d2af614a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1=CC=C(C=C1)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/77883,PubChem,CC(C)(C)c1ccc(C#N)cc1,Train,1,2702,training
-"NZ_CCID:
-2-Amino-5-nitropyridine",,4214-76-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/31C52772-5DAF-45FE-81D3-09A16D8C6C0C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=NC=C1[N+](=O)[O-])N,https://pubchem.ncbi.nlm.nih.gov/compound/77888,PubChem,Nc1ccc([N+](=O)[O-])cn1,Train,1,2702,training
-"NZ_CCID:
-1,1,1-Trifluoroacetone",,421-50-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5FE92409-E429-404F-87EC-8DAAC377DDA8,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/9871,PubChem,CC(=O)C(F)(F)F,Train,1,2702,training
-"NZ_CCID:
-Trifluoromethanesulphonyl chloride","NZ_CCID:
-trifluoromethanesulfonyl chloride",421-83-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D05A8ED9-59B4-4970-B134-D6B9E05AAAB3,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(F)(F)(F)S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/79000,PubChem,O=S(=O)(Cl)C(F)(F)F,Train,1,2702,training
-"EU_CLP:
-2,3,4,5-tetrachlorobenzoylchloride",,42221-52-3,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=C(C(=C(C(=C1Cl)Cl)Cl)Cl)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/5463797,PubChem,O=C(Cl)c1cc(Cl)c(Cl)c(Cl)c1Cl,Test,1,2702,training
-"EU_REACH:
-N,N-bis(2-hydroxypropyl)benzamide",,422278-61-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/9467/7/4/2/?documentUUID=2886a6d2-d8c7-47f0-8bdd-5c9cde1d1f40,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CN(CC(C)O)C(=O)C1=CC=CC=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/11470407,PubChem,CC(O)CN(CC(C)O)C(=O)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-6-Bromohexanoic acid","NZ_CCID:
-6-bromocaproic acid",4224-70-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D735F427-0BD7-463E-BE3A-B191BB6CFAEA,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(CCC(=O)O)CCBr,https://pubchem.ncbi.nlm.nih.gov/compound/20210,PubChem,O=C(O)CCCCCBr,Train,1,2702,training
-"EU_REACH:
-N-ethyl-N-methylcarbamoyl chloride",,42252-34-6,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18957/7/4/2/?documentUUID=d41cdbc2-45d0-4945-b926-da3e2a9b635d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(C)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11240471,PubChem,CCN(C)C(=O)Cl,Train,1,2702,training
-"NZ_CCID:
-2,2,3,3,3-Pentafluoropropionic acid","NZ_CCID:
-pentafluoropropionic acid",422-64-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2A7E15AF-D076-410C-B8C4-CE6563BAE0E6,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(=O)(C(C(F)(F)F)(F)F)O,https://pubchem.ncbi.nlm.nih.gov/compound/62356,PubChem,O=C(O)C(F)(F)C(F)(F)F,Train,1,2702,training
-"EU_REACH:
-2-methylprop-1-ene, pentamer",,42278-27-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12490/7/4/2/?documentUUID=d2ab01e5-ab18-46eb-9865-a7ef85c989b7,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/8255,PubChem,C=C(C)C,Train,1,2702,training
-"NZ_CCID:
-(R)-(-)-1-(1-Naphthyl) ethyl isocyanate",,42340-98-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6EAA259E-9310-414E-867C-3C3FE0AEECAB,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C[C@H](C1=CC=CC2=CC=CC=C21)N=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/170633,PubChem,C[C@@H](N=C=O)c1cccc2ccccc12,Train,1,2702,training
-"EU_CLP:
-2-chloro-p-toluenesulfochloride",,42413-03-6,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC1=C(C=C(C=C1)S(=O)(=O)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/259744,PubChem,Cc1ccc(S(=O)(=O)Cl)cc1Cl,Test,1,2702,training
-"NZ_CCID:
-2,2',4'-Trichloroacetophenone",,4252-78-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A59FFDCD-0C49-496A-B865-40E2B27C84FB,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C=C1Cl)Cl)C(=O)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/20250,PubChem,O=C(CCl)c1ccc(Cl)cc1Cl,Train,1,2702,training
-"EU_REACH:
-methylsilanetriyl triacetate
-
-JP_CHRIP:
-Methylsilanetriyl triacetate
-
-NZ_CCID:
-Silanetriol, methyl-, triacetate, >5% in a non hazardous diluent","JP_CHRIP:
-Methyltriacetoxysilane; Methyltriacetoxysilane; Silane, methyltriacetoxy-; Triacetoxymethylsilane",4253-34-3,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14400/7/4/2/?documentUUID=a36fbd56-64f5-44ba-b560-a28039e745cc
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0032e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/66C959A3-1D52-47B4-ABDD-08A7B3C3347F","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-In a skin irritation test in which six rabbits were given a 4-hour semi-occlusive application of 0.5 mL of this substance (OECD TG 404, GLP), severe lesions were observed 72 hours after the application, and all the animals showed no noticeable recovery on day 14. The primary dermal irritation index was 4.17, and it was judged as corrosive (SIDS (2005)). Therefore, it was classified in Category 1. Besides, in the test, 3-minute exposure also caused erythema and edema, the dermal irritation index was 2.94, and irritation was found (SIDS (2005)).
-
-NZ_CCID:
-Skin Irritation
-Classification based on the pure chemical classification and mixture rules.
-Eye Irritation
-Classification based on the pure chemical classification and mixture rules.",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,CC(=O)O[Si](C)(OC(=O)C)OC(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J54.327F,J-GLOBAL,CC(=O)O[Si](C)(OC(C)=O)OC(C)=O,Train,1,2702,training
-"US_HSDB:
-3,4-Methylenedioxymethamphetamine",,42542-10-9,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/6929,,,US_HSDB,1,CC(CC1=CC2=C(C=C1)OCO2)NC,https://pubchem.ncbi.nlm.nih.gov/compound/1615,PubChem,CNC(C)Cc1ccc2c(c1)OCO2,Train,1,2702,training
-"NZ_CCID:
-Methanesulphonic acid, trifluoro-, ethyl ester",,425-75-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6D9EBE85-02BD-44AD-989E-272EDA26E2D9,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCOS(=O)(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/67924,PubChem,CCOS(=O)(=O)C(F)(F)F,Train,1,2702,training
-"EU_REACH:
-N-(4-chloro-2,5-dimethoxyphenyl)-3-hydroxy-2-naphthamide",,4273-92-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11395/7/4/2/?documentUUID=5b51b5e9-6ee5-4b69-99e8-2bd2727b08df,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC(=C(C=C1NC(=O)C2=CC3=CC=CC=C3C=C2O)OC)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/77955,PubChem,COc1cc(NC(=O)c2cc3ccccc3cc2O)c(OC)cc1Cl,Train,1,2702,training
-"EU_CLP:
-cyclohexadeca-1,9-diene",,4277-06-9,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1CC/C=C\CCCCCC/C=C\CCC1,https://pubchem.ncbi.nlm.nih.gov/compound/44148196,PubChem,C1=C\CCCCCC/C=C\CCCCCC/1,Test,1,2702,training
-"EU_REACH:
-N1,N3-bis(2,2,6,6-tetramethylpiperidin-4-yl)benzene-1,3-dicarboxamide",,42774-15-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16260/7/4/2/?documentUUID=304c1f7c-7c83-49d2-83db-38b19b863213,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(CC(CC(N1)(C)C)NC(=O)C2=CC(=CC=C2)C(=O)NC3CC(NC(C3)(C)C)(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6451919,PubChem,CC1(C)CC(NC(=O)c2cccc(C(=O)NC3CC(C)(C)NC(C)(C)C3)c2)CC(C)(C)N1,Train,1,2702,training
-"EU_REACH:
-5-methyl-1,2-oxazole-4-carboxylic acid",,42831-50-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1590/7/4/2/?documentUUID=17944925-10eb-47cc-aabd-7afa0cd6935a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=NO1)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/1425240,PubChem,Cc1oncc1C(=O)O,Train,1,2702,training
-"EU_REACH:
-(carboxymethyl)(3-dodecanamidopropyl)dimethylazanium hydroxide",,4292-10-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12545/7/4/2/?documentUUID=0f542ac3-ee5f-4779-9785-a1abda54498b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC(=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/20280,PubChem,CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC(=O)[O-],Train,1,2702,training
-"NZ_CCID:
-1-Iodododecane",,4292-19-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CD742BE9-D84A-4F3C-B01B-19580B73B02E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCCCCCCCCCCCI,https://pubchem.ncbi.nlm.nih.gov/compound/20282,PubChem,CCCCCCCCCCCCI,Train,1,2702,training
-"KR_NCIS:
-2-n-Butyl-benzo[d]isothiazol-3-one","KR_NCIS:
-1,2-Benzisothiazol-3(2H)-one, 2-butyl-; 1,2-Benzisothiazolin-3-one, 2-butyl-; 2-Butyl-1,2-benzothiazol-3(2H)-one; 2-Butyl-benzo(d)isothiazol-3-one; N-Butylbenzisothiazolin-3-one",4299-07-4,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCCCN1C(=O)C2=CC=CC=C2S1,https://pubchem.ncbi.nlm.nih.gov/compound/9837171,PubChem,CCCCn1sc2ccccc2c1=O,Train,1,2702,training
-"ChemSkin:
-2-(Formylamino)-3-thiophenecarboxylic acid",,43028-69-9,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,C1=CSC(=C1C(=O)O)NC=O,https://pubchem.ncbi.nlm.nih.gov/compound/3557280,PubChem,O=CNc1sccc1C(=O)O,Test,1,2702,training
-"EU_REACH:
-2,6-di-tert-butyl-4-nonylphenol",,4306-88-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22681/7/4/2/?documentUUID=45c12b73-3f00-4041-b503-4e00968265cd,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCC1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/78004,PubChem,CCCCCCCCCc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1,Train,1,2702,training
-"JP_CHRIP:
-Diacetyl
-
-NZ_CCID:
-2,3-Butanedione
-
-US_HSDB:
-DIACETYL","NZ_CCID:
-2,3-Butadione, 2,3-Dioxobutane, Biacetyl, Butanedione, Diacetyl, Dimethyl diketone, Dimethyl glyoxal",431-03-8,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2003e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5993AE4B-91F2-485C-9AFC-43D4A628DC05
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/297","JP_CHRIP:
-[Rationale for the Classification]
-Based on the case in humans in (1), it was classified in Category 2.
-
-[Evidence Data]
-(1) There is a description that eye, skin and nasal irritation were observed in workers exposed to butter flavoring vapours composed mainly of this substance in popcorn manufacturing facilities (EU SCOEL SUM 149 (2014)).
-
-[Reference Data, etc.]
-(2) There is a description that in a test in which this substance was applied to the skin of rabbits, moderate to severe irritation was observed (PATTY (6th, 2012)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Moderate
-REFERENCE SOURCE:[Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information see FCTOD7. (17,765,1979)]
-[RTECS]
-Eye Irritation
-SPECIES:
-RESULT: Contact with material may irritate or burn eyes.
-REFERENCE SOURCE: [U.S. Department of Transportation. 1996 North American Emergency Response Guidebook. A Guidebook for First Responders During the Initial Phase of aHazardous Materials/Dangerous Goods Incident. U.S. Department of Transportation (U.S. DOT) Research and Special Programs Administration, Office of Hazardous Materials Initiatives and Training (DHM-50), Washington, D.C. (1996).,p. G-127]
-[HSDB]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,CC(=O)C(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.586K,J-GLOBAL,CC(=O)C(C)=O,Train,1,2702,training
-"NZ_CCID:
-Methyl trifluoroacetate",,431-47-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2475B394-DDB3-4585-A0D2-C4AA3ACF02CE,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,COC(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/9893,PubChem,COC(=O)C(F)(F)F,Train,1,2702,training
-"EU_REACH:
-2,3-difluoro-1-methoxy-4-[(trans,trans)-4'-propyl[1,1'-bicyclohexyl]-4-yl]-benzene",,431947-34-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21335/7/4/2/?documentUUID=68fe7e6f-e5c0-4f64-a039-10cd065b0735,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2CCC(CC2)C3=C(C(=C(C=C3)OC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/17795588,PubChem,CCCC1CCC(C2CCC(c3ccc(OC)c(F)c3F)CC2)CC1,Train,1,2702,training
-"NZ_CCID:
-4-Aminomorpholine",,4319-49-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3DBDDBFF-AA67-4DDA-83BA-6C1BFD600F28,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1COCCN1N,https://pubchem.ncbi.nlm.nih.gov/compound/20315,PubChem,NN1CCOCC1,Train,1,2702,training
-"NZ_CCID:
-2,2,2-Trifluoroacetophenone",,434-45-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D5D218B3-C7DF-4A60-B505-1A97F9394E89,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)C(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/9905,PubChem,O=C(c1ccccc1)C(F)(F)F,Train,1,2702,training
-"EU_CLP:
-acrylic acid, 3-(trimethoxysilyl)propyl ester",,4369-14-6,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CO[Si](CCCOC(=O)C=C)(OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/151204,PubChem,C=CC(=O)OCCC[Si](OC)(OC)OC,Test,1,2702,training
-"EU_REACH:
-4-Ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl) benzenesulfonic acid",,437717-43-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6990/7/4/2/?documentUUID=475c45bd-5b29-4d78-bedc-6fc6b42678f5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1=NC(=C2N1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)O)OCC)C,https://pubchem.ncbi.nlm.nih.gov/compound/135483690,PubChem,CCCc1nc(C)c2c(=O)[nH]c(-c3cc(S(=O)(=O)O)ccc3OCC)nn12,Train,1,2702,training
-"EU_CLP:
-3-aminobenzylamine",,4403-70-7,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC(=CC(=C1)N)CN,https://pubchem.ncbi.nlm.nih.gov/compound/4628831,PubChem,NCc1cccc(N)c1,Test,1,2702,training
-"EU_REACH:
-2,5,7,10-tetraoxaundecane",,4431-83-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10866/7/4/2/?documentUUID=005e0317-db24-48d9-bf5a-e64924875489,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COCCOCOCCOC,https://pubchem.ncbi.nlm.nih.gov/compound/78164,PubChem,COCCOCOCCOC,Train,1,2702,training
-"EU_REACH:
-N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutanamide",,4433-79-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1944/7/4/2/?documentUUID=c97d07b1-aaf0-40ee-84bc-c92d937d3590,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)CC(=O)NC1=CC(=C(C=C1OC)Cl)OC,https://pubchem.ncbi.nlm.nih.gov/compound/78170,PubChem,COc1cc(NC(=O)CC(C)=O)c(OC)cc1Cl,Train,1,2702,training
-"EU_REACH:
-3-methoxybutyl acetate",,4435-53-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5167/7/4/2/?documentUUID=6739342c-cbb4-45e7-acf2-e24f71006404,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CCOC(=O)C)OC,https://pubchem.ncbi.nlm.nih.gov/compound/20498,PubChem,COC(C)CCOC(C)=O,Train,1,2702,training
-"EU_REACH:
-trimorpholinophosphine oxide",,4441-12-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23808/7/4/2/?documentUUID=11e8351c-1e8d-4775-8173-bb598591d607,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1COCCN1P(=O)(N2CCOCC2)N3CCOCC3,https://pubchem.ncbi.nlm.nih.gov/compound/78180,PubChem,O=P(N1CCOCC1)(N1CCOCC1)N1CCOCC1,Train,1,2702,training
-"EU_REACH:
-2-hydroxy-3-(prop-2-enoyloxy)propyl 2-methyl-2-propylhexanoate",,444649-70-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19415/7/4/2/?documentUUID=1543e717-cec8-4fd3-ab59-f72b49215449,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(C)(CCC)C(=O)OCC(COC(=O)C=C)O,https://pubchem.ncbi.nlm.nih.gov/compound/153372430,PubChem,C=CC(=O)OCC(O)COC(=O)C(C)(CCC)CCCC,Train,1,2702,training
-"EU_REACH:
-1,3-bis(2-ethylhexyl) 2-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]propanedioate",,444811-29-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/3781/7/4/2/?documentUUID=93ec83e0-58ad-4587-bc05-cce21dbbcb38,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)C(=CC1=CC(=C(C(=C1)OC)O)OC)C(=O)OCC(CC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/10163591,PubChem,CCCCC(CC)COC(=O)C(=Cc1cc(OC)c(O)c(OC)c1)C(=O)OCC(CC)CCCC,Train,1,2702,training
-"NZ_CCID:
-2-Fluorobenzoic acid",,445-29-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9782FFC2-7067-4083-88BD-B0216807CD41,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)C(=O)O)F,https://pubchem.ncbi.nlm.nih.gov/compound/9935,PubChem,O=C(O)c1ccccc1F,Train,1,2702,training
-"NZ_CCID:
-2-Fluorobenzaldehyde",,446-52-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1DF6F31C-B98F-4DE1-9BE8-C7A09E99E1F0,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)C=O)F,https://pubchem.ncbi.nlm.nih.gov/compound/67970,PubChem,O=Cc1ccccc1F,Train,1,2702,training
-"EU_CLP:
-2-methyl-2-azabicyclo[2.2.1]heptane",,4524-95-2,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CN1CC2CCC1C2,https://pubchem.ncbi.nlm.nih.gov/compound/20618,PubChem,CN1CC2CCC1C2,Test,1,2702,training
-"NZ_CCID:
-Dicarbonic acid, dimethyl ester","NZ_CCID:
-DMDC, Dimethyl dicarbonate, Dimethyl pryocarbonate",4525-33-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F21434E1-9F62-49FF-90F2-09B6742C8935,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 36/ 38. [MSDS http://www.sciencelab.com/page/S/PVAR/10411/SLD1258]
-Eye Irritation
-R-PHRASE: R 36/ 38. [MSDS http://www.sciencelab.com/page/S/PVAR/10411/SLD1258]",,NZ_CCID,1,COC(=O)OC(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/3086,PubChem,COC(=O)OC(=O)OC,Train,1,2702,training
-"AU_HCIS:
-Tetradecanamide, N-[3-(dimethylamino)propyl]-",,45267-19-4,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6765,,,AU_HCIS,1,CCCCCCCCCCCCCC(=O)NCCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/170759,PubChem,CCCCCCCCCCCCCC(=O)NCCCN(C)C,Train,1,2702,training
-"NZ_CCID:
-4-Methylcatechol",,452-86-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1AD70B8C-85EF-49A4-85F2-5197398D134F,,,NZ_CCID,1,CC1=CC(=C(C=C1)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/9958,PubChem,Cc1ccc(O)c(O)c1,Train,1,2702,training
-"NZ_CCID:
-2-Methylhexanoic acid",,4536-23-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/41DFFD22-9CE9-4DA5-A55E-8F6E99AB25C0,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCC(C)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/20653,PubChem,CCCCC(C)C(=O)O,Train,1,2702,training
-"AU_HCIS:
-Ethanol, 2-(dodecyloxy)-",,4536-30-5,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6496,,,AU_HCIS,1,CCCCCCCCCCCCOCCO,https://pubchem.ncbi.nlm.nih.gov/compound/24750,PubChem,CCCCCCCCCCCCOCCO,Train,1,2702,training
-"KR_NCIS:
-Pentamethylene diisocyanate; 1,5-Diisocyanatopentane;",,4538-42-5,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C(CCN=C=O)CCN=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/11948526,PubChem,O=C=NCCCCCN=C=O,Train,1,2702,training
-"NZ_CCID:
-4-Aminobenzotrifluoride",,455-14-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/40687274-03BE-4345-8E0F-AF200E7C9A2F,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1C(F)(F)F)N,https://pubchem.ncbi.nlm.nih.gov/compound/9964,PubChem,Nc1ccc(C(F)(F)F)cc1,Train,1,2702,training
-"NZ_CCID:
-3,4-Difluorobenzoic acid",,455-86-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/19CBA9F5-9C96-4DDB-949A-28E01077807B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C=C1C(=O)O)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/99166,PubChem,O=C(O)c1ccc(F)c(F)c1,Train,1,2702,training
-"NZ_CCID:
-4-Fluorobenzoic acid",,456-22-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/38611BEB-82A8-4C61-B3E8-07C1DC6ECD5A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1C(=O)O)F,https://pubchem.ncbi.nlm.nih.gov/compound/9973,PubChem,O=C(O)c1ccc(F)cc1,Train,1,2702,training
-"NZ_CCID:
-3-Fluorobenzyl bromide",,456-41-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FAABFE75-711A-47D6-84B1-2F6B03B1112C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)F)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/68007,PubChem,Fc1cccc(CBr)c1,Train,1,2702,training
-"NZ_CCID:
-3-Fluorobenzyl chloride",,456-42-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7C3F465D-985B-4935-905E-D7966B5EE684,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)F)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/9974,PubChem,Fc1cccc(CCl)c1,Train,1,2702,training
-"NZ_CCID:
-3-Fluorobenzaldehyde",,456-48-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/29FD19D6-C764-470B-95D4-C5D211E016E3,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)F)C=O,https://pubchem.ncbi.nlm.nih.gov/compound/68009,PubChem,O=Cc1cccc(F)c1,Train,1,2702,training
-"EU_REACH:
-farnesol",,4602-84-0,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23466/7/4/2/?documentUUID=4972189d-bc8c-49bf-acbf-8cdb879729b2,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=CCCC(=CCCC(=CCO)C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/3327,PubChem,CC(C)=CCCC(C)=CCCC(C)=CCO,Train,1,2702,training
-"EU_REACH:
-hydantoin",,461-72-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22662/7/4/2/?documentUUID=681bb512-22ee-4948-940e-a442478b0491,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C(=O)NC(=O)N1,https://pubchem.ncbi.nlm.nih.gov/compound/10006,PubChem,O=C1CNC(=O)N1,Train,1,2702,training
-"EU_CLP:
-1-bromo-3,5-difluorobenzene",,461-96-1,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=C(C=C(C=C1F)Br)F,https://pubchem.ncbi.nlm.nih.gov/compound/136313,PubChem,Fc1cc(F)cc(Br)c1,Test,1,2702,training
-"EU_REACH:
-fluorobenzene",,462-06-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1885/7/4/2/?documentUUID=3ba8733e-3d90-4f5c-bc9a-0aa1d627b82f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)F,https://pubchem.ncbi.nlm.nih.gov/compound/10008,PubChem,Fc1ccccc1,Train,1,2702,training
-"NZ_CCID:
-2-t-Butylamino-ethanol","NZ_CCID:
-2-(tert-butylamino)ethanol, 2-Tert-butylamino-ethanol",4620-70-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C4DF664E-1E6D-46B0-9337-E86E74814EB0,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 38. [Company data]
-Eye Irritation
-R-PHRASE: R 36. [Company data]",,NZ_CCID,1,CC(C)(C)NCCO,https://pubchem.ncbi.nlm.nih.gov/compound/78361,PubChem,CC(C)(C)NCCO,Train,1,2702,training
-"NZ_CCID:
-3-Aminopyridine","NZ_CCID:
-m-aminopyridine",462-08-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0F91F832-A423-4084-8799-C28B5077DFB1,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CN=C1)N,https://pubchem.ncbi.nlm.nih.gov/compound/10009,PubChem,Nc1cccnc1,Train,1,2702,training
-"EU_REACH:
-6,8-disulfanyloctanoic acid",,462-20-4,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11996/7/4/2/?documentUUID=6a26dfcc-045c-431f-8abb-da9992740806,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CCC(=O)O)CC(CCS)S,https://pubchem.ncbi.nlm.nih.gov/compound/421,PubChem,O=C(O)CCCCC(S)CCS,Train,1,2702,training
-"EU_REACH:
-2-(1,3-oxazolidin-3-yl)ethyl 2-methylprop-2-enoate",,46235-93-2,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23768/7/4/2/?documentUUID=8086295f-9774-44ed-9df1-93e7e3035815,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OCCN1CCOC1,https://pubchem.ncbi.nlm.nih.gov/compound/162072,PubChem,C=C(C)C(=O)OCCN1CCOC1,Train,1,2702,training
-"KR_NCIS:
-4-Chlorobutanoyl chloride
-
-NZ_CCID:
-4-Chlorobutyryl chloride",,4635-59-0,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4C089735-7A38-4504-AB9A-B2A66D62B3B0","NZ_CCID:
-Skin Irritation
-R PHRASE: R 35 [Company Data]
-Eye Irritation
-R PHRASE: R 35 [Company Data]",,"KR_NCIS, NZ_CCID",2,C(CC(=O)Cl)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/78370,PubChem,O=C(Cl)CCCCl,Train,1,2702,training
-"NZ_CCID:
-Thiophosgene","NZ_CCID:
-Carbon chlorosulfide, Carbonic dichloride, thio-, Carbonothioic dichloride, Dichlorothiocarbonyl, Thiocarbonic dichloride, Thiocarbonyl chloride, Thiocarbonyl dichloride",463-71-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/19B8EC2F-1FAA-4EF1-A964-DDFE37F784BD,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB - Annex 1]
-Eye Irritation
-R36/37/38 : Irritating to eyes, respiratory system and skin.
-[ECB - Annex 1]",,NZ_CCID,1,C(=S)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10040,PubChem,S=C(Cl)Cl,Train,1,2702,training
-"NZ_CCID:
-2,2,3-Trimethylbutane",,464-06-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AF8A3FA0-DED5-4AC6-8616-2EE3BEA04F82,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]",,NZ_CCID,1,CC(C)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/10044,PubChem,CC(C)C(C)(C)C,Train,1,2702,training
-"EU_REACH:
-Dimethyl ethenylphosphonate",,4645-32-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19763/7/4/2/?documentUUID=33b2a429-0c2a-4320-86c1-4b987ad0a965,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COP(=O)(C=C)OC,https://pubchem.ncbi.nlm.nih.gov/compound/78376,PubChem,C=CP(=O)(OC)OC,Train,1,2702,training
-"NZ_CCID:
-2,6-Dichlorobenzoyl chloride",,4659-45-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0F224BEC-9527-4E45-8C5F-35D14D1BD27B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=C(C(=C1)Cl)C(=O)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/78392,PubChem,O=C(Cl)c1c(Cl)cccc1Cl,Train,1,2702,training
-"EU_REACH:
-6-(N-methylbenzenesulfonamido)hexanoic acid",,46948-72-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11110/7/4/2/?documentUUID=c9a35ef8-5553-4b94-9a8f-9ef8585905b9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(CCCCCC(=O)O)S(=O)(=O)C1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/117892,PubChem,CN(CCCCCC(=O)O)S(=O)(=O)c1ccccc1,Train,1,2702,training
-"EU_REACH:
-10-methoxy-5H-dibenzo[b,f]azepine",,4698-11-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13198/7/4/2/?documentUUID=5871a3d5-18b5-4494-b786-90c6af1a8137,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC2=CC=CC=C2NC3=CC=CC=C31,https://pubchem.ncbi.nlm.nih.gov/compound/78424,PubChem,COC1=Cc2ccccc2Nc2ccccc21,Train,1,2702,training
-"JP_CHRIP:
-Propiolic acid",,471-25-0,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0168e.html,"JP_CHRIP:
-On the basis that a test applied an undiluted test substance to the abdominal skin of guinea pigs for 24 hours reported a moderately strong irritant (PATTY (5th, 2001)), it was classified in Category 2.
-Besides, there is the information that this substance was extremely destructive to tissues of the mucous membranes, upper respiratory tract, eyes, and skin (HSDB (2011)).",,JP_CHRIP,1,OC(=O)C#C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.941B,J-GLOBAL,C#CC(=O)O,Train,1,2702,training
-"EU_REACH:
-2,2',2''-(1,3,5-triazinane-1,3,5-triyl)triethanol",,4719-04-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15014/7/4/2/?documentUUID=e599d108-5d4e-4062-943e-3f58c2d9b30d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1N(CN(CN1CCO)CCO)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/104556,PubChem,OCCN1CN(CCO)CN(CCO)C1,Train,1,2702,training
-"EU_REACH:
-octylphosphonic acid
-
-NZ_CCID:
-Phosphonic acid, octyl-",,4724-48-5,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14433/7/4/2/?documentUUID=40a22159-5b31-4234-be9f-ef2f15e1d148
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DB6BB842-838D-4B12-9069-71CD8D9BDEFB","EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,"EU_REACH, NZ_CCID",2,CCCCCCCCP(=O)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/78452,PubChem,CCCCCCCCP(=O)(O)O,Train,1,2702,training
-"EU_REACH:
-(1r,4r)-4-(2,3-difluoro-4-propoxyphenyl)-4'-propyl-1,1'-bi(cyclohexane)",,473257-14-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21362/7/4/2/?documentUUID=caa3a662-0671-4d73-a322-39a77728d026,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2CCC(CC2)C3=C(C(=C(C=C3)OCCC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/58471750,PubChem,CCCOc1ccc(C2CCC(C3CCC(CCC)CC3)CC2)c(F)c1F,Train,1,2702,training
-"EU_REACH:
-(1'r,4'r)-4-butyl-4'-(4-ethoxy-2,3-difluorophenyl)-1,1'-bi(cyclohexane)",,473257-15-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21378/7/4/2/?documentUUID=2d784388-24b5-4a2c-b999-c1b54f43f227,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC1CCC(CC1)C2CCC(CC2)C3=C(C(=C(C=C3)OCC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/53487172,PubChem,CCCCC1CCC(C2CCC(c3ccc(OCC)c(F)c3F)CC2)CC1,Train,1,2702,training
-"NZ_CCID:
-2,3-Dicyanohydroquinone",,4733-50-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/75ABAF4A-B30F-461F-A78B-A645385CA2FF,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C(=C1O)C#N)C#N)O,https://pubchem.ncbi.nlm.nih.gov/compound/78467,PubChem,N#Cc1c(O)ccc(O)c1C#N,Train,1,2702,training
-"EU_REACH:
-(4Z)-4-{[4-(diethylamino)phenyl]methylidene}-3-ethoxy-1-phenyl-4,5-dihydro-1H-pyrazol-5-one",,474044-10-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7810/7/4/2/?documentUUID=b90d13a8-fe26-4feb-b28e-23e2f4d2a23f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(CC)C1=CC=C(C=C1)C=C2C(=NN(C2=O)C3=CC=CC=C3)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/68021382,PubChem,CCOC1=NN(c2ccccc2)C(=O)C1=Cc1ccc(N(CC)CC)cc1,Train,1,2702,training
-"EU_REACH:
-2-hydroxy-1-(4-{[4-(2-hydroxy-2-methylpropanoyl)phenyl]methyl}phenyl)-2-methylpropan-1-one",,474510-57-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5067/7/4/2/?documentUUID=3f38165e-45df-4534-a896-02b5ab2a06d3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C(=O)C1=CC=C(C=C1)CC2=CC=C(C=C2)C(=O)C(C)(C)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/22019754,PubChem,CC(C)(O)C(=O)c1ccc(Cc2ccc(C(=O)C(C)(C)O)cc2)cc1,Train,1,2702,training
-"EU_REACH:
-2-Hexyl-2 ‘-hydroxy-5 ‘methyldecananilide",,474754-93-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/3406/7/4/2/?documentUUID=83dc70bd-f9f9-463d-a197-6ca35d85e401,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCC(CCCCCC)C(=O)NC1=C(C=CC(=C1)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/58720637,PubChem,CCCCCCCCC(CCCCCC)C(=O)Nc1cc(C)ccc1O,Train,1,2702,training
-"NZ_CCID:
-Ethyl chloroglyoxylate","NZ_CCID:
-ethyl oxalyl chloride",4755-77-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6E92B85A-0462-4977-88B8-3AB706F0A894,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCOC(=O)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/20884,PubChem,CCOC(=O)C(=O)Cl,Train,1,2702,training
-"NZ_CCID:
-Methyl 2-chloroacetoacetate",,4755-81-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AE2A30C3-7106-41FE-86D8-63CFFAA38E06,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CC(=O)C(C(=O)OC)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/107332,PubChem,COC(=O)C(Cl)C(C)=O,Train,1,2702,training
-"KR_NCIS:
-13-cis-Retinoic acid
-
-NZ_CCID:
-Isotretinoin
-
-US_HSDB:
-13-cis-Retinoic acid","KR_NCIS:
-(2Z,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)nona-2,4,6,8-tetraenoic acid; 13-cis-Retinoic acid; Isotretinoin",4759-48-2,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F9CC5C64-A7C3-445B-BAA2-F48F9295B9E6
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/3929","NZ_CCID:
-Skin Irritation
-REMARK: Confidential information supplied by registrant.
-Eye Irritation
-REMARK: Confidential information supplied by registrant.",,"KR_NCIS, NZ_CCID, US_HSDB",3,CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C\C(=O)O)/C)/C,https://pubchem.ncbi.nlm.nih.gov/compound/5282379,PubChem,CC1=C(/C=C/C(C)=C/C=C/C(C)=C\C(=O)O)C(C)(C)CCC1,Train,1,2702,training
-"EU_REACH:
-2-[(1S)-1-[(1R)-3,3-dimethylcyclohexyl]ethoxy]-2-methylpropyl cyclopropanecarboxylate; 2-[(1S)-1-[(1S)-3,3-dimethylcyclohexyl]ethoxy]-2-methylpropyl cyclopropanecarboxylate",,477218-42-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31599/7/4/2/?documentUUID=ce6d6a08-e071-4b8f-910f-b1ce59b39959,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C1CCCC(C1)(C)C)OC(C)(C)COC(=O)C2CC2,https://pubchem.ncbi.nlm.nih.gov/compound/12022011,PubChem,CC(OC(C)(C)COC(=O)C1CC1)C1CCCC(C)(C)C1,Train,1,2702,training
-"EU_REACH:
-4-methyl-4'-[(3E)-pent-3-en-1-yl]-1,1'-biphenyl",,478385-88-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5831/7/4/2/?documentUUID=ca59befc-3db2-47b4-831d-d59e6063f43a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C/C=C/CCC1=CC=C(C=C1)C2=CC=C(C=C2)C,https://pubchem.ncbi.nlm.nih.gov/compound/20727466,PubChem,C/C=C/CCc1ccc(-c2ccc(C)cc2)cc1,Train,1,2702,training
-"JP_CHRIP:
-N-methyl-N,2,4,6-tetranitroaniline","JP_CHRIP:
-2,4,6-Trinitrophenylmethylnitramine
-N-Methyl-N,2,4,6-tetranitrobenzenamine
-Nitramine
-Picrylnitromethylamine",479-45-8,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0837e.html,"JP_CHRIP:
-It was set as Category 2 from description that there was skin irritation as effect of the humans (ACGIH (7th, 2001), PATTY (4th, 1994), DFGOT (vol.1, 1998)).",,JP_CHRIP,1,CN(c1c(cc(cc1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J6.159J,J-GLOBAL,CN(c1c([N+](=O)[O-])cc([N+](=O)[O-])cc1[N+](=O)[O-])[N+](=O)[O-],Train,1,2702,training
-"EU_REACH:
-2-phenoxyethyl prop-2-enoate",,48145-04-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5368/7/4/2/?documentUUID=7050ce54-3924-4cd7-ae0e-20e20365cd10,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CC(=O)OCCOC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/39485,PubChem,C=CC(=O)OCCOc1ccccc1,Train,1,2702,training
-"US_HSDB:
-Chrysophanic acid",,481-74-3,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8483,,,US_HSDB,1,CC1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=CC=C3O,https://pubchem.ncbi.nlm.nih.gov/compound/10208,PubChem,Cc1cc(O)c2c(c1)C(=O)c1cccc(O)c1C2=O,Train,1,2702,training
-"NZ_CCID:
-Ninhydrin",,485-47-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0B48A30E-760B-47DD-AA28-5B6EF48F7F57,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C2C(=C1)C(=O)C(C2=O)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/10236,PubChem,O=C1c2ccccc2C(=O)C1(O)O,Train,1,2702,training
-"EU_REACH:
-4-(4-butylphenyl)-4'-ethyl-2,3-difluoro-1,1'-biphenyl",,486406-09-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20480/7/4/2/?documentUUID=8e8f4cb8-30b4-4dc9-8158-80e6f11081c3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC1=CC=C(C=C1)C2=C(C(=C(C=C2)C3=CC=C(C=C3)CC)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/58731454,PubChem,CCCCc1ccc(-c2ccc(-c3ccc(CC)cc3)c(F)c2F)cc1,Train,1,2702,training
-"NZ_CCID:
-Bromophenylacetic acid",,4870-65-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8DF85E60-C448-45A2-8A0C-16170429680E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C(C=C1)C(C(=O)O)Br,https://pubchem.ncbi.nlm.nih.gov/compound/97919,PubChem,O=C(O)C(Br)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-1,2-Benzenediol, 3-methyl-",,488-17-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0BAE334C-54FB-451F-9E41-9F7DEDAA266D,,,NZ_CCID,1,CC1=C(C(=CC=C1)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/340,PubChem,Cc1cccc(O)c1O,Train,1,2702,training
-"NZ_CCID:
-Dichloromethyl methyl ether","NZ_CCID:
-1,1-dichlorodimethyl ether",4885-02-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/131760D0-A849-43F1-9F55-00EE27F040E0,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,COC(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/21004,PubChem,COC(Cl)Cl,Train,1,2702,training
-"NZ_CCID:
-2,5-Dimethylresorcinol",,488-87-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/39F1A456-C8C9-4C76-A2B4-E259D94E8E3A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CC1=CC(=C(C(=C1)O)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/68103,PubChem,Cc1cc(O)c(C)c(O)c1,Train,1,2702,training
-"NZ_CCID:
-3-Furancarboxylic acid","NZ_CCID:
-3-furoic acid",488-93-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/443A6641-CB08-44AA-B05F-C0049EB2CD38,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=COC=C1C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/10268,PubChem,O=C(O)c1ccoc1,Train,1,2702,training
-"EU_REACH:
-4-Hydroxyquinazoline",,491-36-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25893/7/4/2/?documentUUID=38f830ed-54c2-4a7d-b6b3-46b36c60e5f4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C(=O)NC=N2,https://pubchem.ncbi.nlm.nih.gov/compound/135408753,PubChem,O=c1[nH]cnc2ccccc12,Train,1,2702,training
-"NZ_CCID:
-2-Phenylpropionic acid",,492-37-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F74D7CC1-794C-4B23-AD71-A3476EDEF0E8,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C1=CC=CC=C1)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/10296,PubChem,CC(C(=O)O)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-cis-Decahydronaphthalene",,493-01-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FF5A5563-AF95-4606-A66A-B00B8B4C5C5E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CCC2CCCCC2C1,https://pubchem.ncbi.nlm.nih.gov/compound/7044,PubChem,C1CCC2CCCCC2C1,Train,1,2702,training
-"EU_REACH:
-3-cyclopentyl-1H-indole-6-carboxylic acid",,494799-36-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5604/7/4/2/?documentUUID=5bbde926-7cf3-47b2-8aef-ede8eb68b47d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CCC(C1)C2=CNC3=C2C=CC(=C3)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/21874473,PubChem,O=C(O)c1ccc2c(C3CCCC3)c[nH]c2c1,Train,1,2702,training
-"EU_REACH:
-methyl 3-cyclopentyl-1-methyl-1H-indole-6-carboxylate",,494799-38-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5766/7/4/2/?documentUUID=ce475ab8-7fee-441b-b323-90cf411e3820,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN1C=C(C2=C1C=C(C=C2)C(=O)OC)C3CCCC3,https://pubchem.ncbi.nlm.nih.gov/compound/59658510,PubChem,COC(=O)c1ccc2c(C3CCCC3)cn(C)c2c1,Train,1,2702,training
-"AU_HCIS:
-1,3-Benzenediamine, 4-(phenylazo)-",,495-54-5,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5298,,,AU_HCIS,1,C1=CC=C(C=C1)N=NC2=C(C=C(C=C2)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/10317,PubChem,Nc1ccc(N=Nc2ccccc2)c(N)c1,Train,1,2702,training
-"EU_REACH:
-4-amino-5-methoxy-N,2-dimethylbenzene-1-sulfonamide",,49564-57-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5755/7/4/2/?documentUUID=9da643d0-73ca-4735-9b29-b4e313343169,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1S(=O)(=O)NC)OC)N,https://pubchem.ncbi.nlm.nih.gov/compound/170791,PubChem,CNS(=O)(=O)c1cc(OC)c(N)cc1C,Train,1,2702,training
-"EU_REACH:
-2-hydroxy-4-methylbenzamide",,49667-22-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5080/7/4/2/?documentUUID=4be9aba2-5f93-45b8-ae2b-e2c0552986d1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)C(=O)N)O,https://pubchem.ncbi.nlm.nih.gov/compound/10534839,PubChem,Cc1ccc(C(N)=O)c(O)c1,Train,1,2702,training
-"EU_REACH:
-4-amino-2,5-dimethoxy-N-methylbenzene-1-sulfonamide",,49701-24-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5400/7/4/2/?documentUUID=366094a7-fa9d-4242-a60b-7ed2555b90c2,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CNS(=O)(=O)C1=C(C=C(C(=C1)OC)N)OC,https://pubchem.ncbi.nlm.nih.gov/compound/170801,PubChem,CNS(=O)(=O)c1cc(OC)c(N)cc1OC,Train,1,2702,training
-"EU_REACH:
-N-(2,2-dimethoxyethyl)prop-2-enamide",,49707-23-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33500/7/4/2/?documentUUID=5faa7fa2-6538-4589-b667-d7c67ebd3e6b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(CNC(=O)C=C)OC,https://pubchem.ncbi.nlm.nih.gov/compound/9898899,PubChem,C=CC(=O)NCC(OC)OC,Train,1,2702,training
-"EU_REACH:
-carbonohydrazide",,497-18-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13675/7/4/2/?documentUUID=2d268e7a-7b15-4d4e-9ea3-aefe926e4b2b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(=O)(NN)NN,https://pubchem.ncbi.nlm.nih.gov/compound/73948,PubChem,NNC(=O)NN,Test,1,2702,training
-"EU_CLP:
-pentaerythritol tetraacrylate",,4986-89-4,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C=CC(=O)OCC(COC(=O)C=C)(COC(=O)C=C)COC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/62556,PubChem,C=CC(=O)OCC(COC(=O)C=C)(COC(=O)C=C)COC(=O)C=C,Test,1,2702,training
-"NZ_CCID:
-2,4-Pyridinedicarboxylic acid",,499-80-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D25F447B-215E-49AD-B659-E6FA8297FBAF,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CN=C(C=C1C(=O)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/10365,PubChem,O=C(O)c1ccnc(C(=O)O)c1,Train,1,2702,training
-"NZ_CCID:
-Pyridine-3,5-dicarboxylic acid","NZ_CCID:
-3,5-pyridinedicarboxylic acid",499-81-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C5DC5110-97DF-467A-87E8-DEEB478EABCA,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=C(C=NC=C1C(=O)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/10366,PubChem,O=C(O)c1cncc(C(=O)O)c1,Train,1,2702,training
-"NZ_CCID:
-Dipicolinic acid","NZ_CCID:
-2,6-pyridinedicarboxylic acid",499-83-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F2AF65D6-458A-4006-BAF4-89FB5D83A8E3,"NZ_CCID:
-Skin Irritation
-PHRASE: R 38 [Company Data]
-Eye Irritation
-PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=NC(=C1)C(=O)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/10367,PubChem,O=C(O)c1cccc(C(=O)O)n1,Train,1,2702,training
-"EU_REACH:
-ethyl 2-(3-chloropyridin-2-yl)-5-oxopyrazolidine-3-carboxylate",,500011-88-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30952/7/4/2/?documentUUID=82c96e62-a017-4596-b366-440d6bdb9ffd,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1CC(=O)NN1C2=C(C=CC=N2)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/22280352,PubChem,CCOC(=O)C1CC(=O)NN1c1ncccc1Cl,Train,1,2702,training
-"NZ_CCID:
-3-Pyridinecarbaldehyde",,500-22-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5B71E72F-7C17-4A3B-8EAE-E1D8B740B91E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 41 [Company Data]",,NZ_CCID,1,C1=CC(=CN=C1)C=O,https://pubchem.ncbi.nlm.nih.gov/compound/10371,PubChem,O=Cc1cccnc1,Train,1,2702,training
-"NZ_CCID:
-3-Phenylpropionic acid",,501-52-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/80A37CDB-528D-4AA6-BB3B-BF75D4B59C94,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)CCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/107,PubChem,O=C(O)CCc1ccccc1,Train,1,2702,training
-"NZ_CCID:
-Benzyl chloroformate",,501-53-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/00F8CB4A-A80C-4B7B-94BB-A929908D89E9,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)COC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10387,PubChem,O=C(Cl)OCc1ccccc1,Train,1,2702,training
-"NZ_CCID:
-4-Hydroxycinnamic acid, trans",,501-98-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A8A9FA6D-FD58-4313-9098-3AB6D709785D,,,NZ_CCID,1,C1=CC(=CC=C1/C=C/C(=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/637542,PubChem,O=C(O)/C=C/c1ccc(O)cc1,Train,1,2702,training
-"NZ_CCID:
-Cyclooctanone",,502-49-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DD577267-2B9E-4731-976E-6F869523A0A6,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CCCC(=O)CCC1,https://pubchem.ncbi.nlm.nih.gov/compound/10403,PubChem,O=C1CCCCCCC1,Train,1,2702,training
-"EU_REACH:
-1,4-dioxane-2,5-dione",,502-97-6,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20813/7/4/2/?documentUUID=d50ec996-9538-4411-b376-5c016cb08619,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C(=O)OCC(=O)O1,https://pubchem.ncbi.nlm.nih.gov/compound/65432,PubChem,O=C1COC(=O)CO1,Train,1,2702,training
-"NZ_CCID:
-2,6-Dichlorobenzoic acid",,50-30-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D6BEB471-1291-4B58-A0B7-FECA410065FD,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C(=C1)Cl)C(=O)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/5758,PubChem,O=C(O)c1c(Cl)cccc1Cl,Train,1,2702,training
-"JP_CHRIP:
-Benzo[a]pyrene","JP_CHRIP:
-3,4-Benzopyrene
-B[a]P
-BaP
-Benz(a)pyrene
-Benzo(d,e,f)chrysene",50-32-8,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0941e.html,"JP_CHRIP:
-There was no concrete case report. But it was set as Category 2 from description that the irritation accompanied by erythema and burning sensations was in the skin in the humans (HSDB (2005), HSFS (1998), and SITTIG (4th, 2002)).",,JP_CHRIP,1,c1ccc2c(c1)cc1ccc3cccc4ccc2c1c34,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.297G,J-GLOBAL,c1ccc2c(c1)cc1ccc3cccc4ccc2c1c34,Train,1,2702,training
-"NZ_CCID:
-Azetidine",,503-29-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9CD60BD8-6713-4E93-94F1-199A94148232,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CNC1,https://pubchem.ncbi.nlm.nih.gov/compound/10422,PubChem,C1CNC1,Train,1,2702,training
-"NZ_CCID:
-Trichloromethyl chloroformate",,503-38-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1C73802D-5EE9-4DC6-BF9F-D2F1E8E676DD,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(=O)(OC(Cl)(Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10426,PubChem,O=C(Cl)OC(Cl)(Cl)Cl,Train,1,2702,training
-"NZ_CCID:
-Isopentanoic acid","NZ_CCID:
-isovaleric acid",503-74-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1D9021C2-46B2-4336-A55E-2A3E173B43A2,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)CC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/10430,PubChem,CC(C)CC(=O)O,Train,1,2702,training
-"NZ_CCID:
-4-Aminopyridine","NZ_CCID:
-4-AP, 4-PYRIDINAMINE, 4-PYRIDYLAMINE, Fampridine, PYRIDINE, 4-AMINO-, p-aminopyridine",504-24-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/80D5A238-5E7E-4322-A522-FE5EF0A18ECF,"NZ_CCID:
-Skin Irritation
-SPECIES:
-RESULT: Causes local irritation on contact with the skin, mucous membranes and cornea.
-REFERENCE SOURCE: International Labour Office. Encyclopedia of Occupational Health and Safety. Vols. I&II. Geneva, Switzerland: International Labour Office, 1983., p. 1810]**PEER REVIEWED** [HSDB]
-Eye Irritation
-SPECIES:
-RESULT: Causes local irritation on contact with the skin, mucous membranes and cornea.
-REFERENCE SOURCE: International Labour Office. Encyclopedia of Occupational Health and Safety. Vols. I&II. Geneva, Switzerland: International Labour Office, 1983., p. 1810]**PEER REVIEWED** [HSDB]",,NZ_CCID,1,C1=CN=CC=C1N,https://pubchem.ncbi.nlm.nih.gov/compound/1727,PubChem,Nc1ccncc1,Train,1,2702,training
-"EU_REACH:
-2-ethylhexyl 3-sulfanylpropanoate",,50448-95-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26266/7/4/2/?documentUUID=a260691f-bb5c-4b24-8447-d17d27e87ead,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)CCS,https://pubchem.ncbi.nlm.nih.gov/compound/92640,PubChem,CCCCC(CC)COC(=O)CCS,Train,1,2702,training
-"US_HSDB:
-1,3-Propanediol",,504-63-2,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8263,,,US_HSDB,1,C(CO)CO,https://pubchem.ncbi.nlm.nih.gov/compound/10442,PubChem,OCCCO,Train,1,2702,training
-"NZ_CCID:
-4-Amino-N-benzylpiperidine","NZ_CCID:
-4-amino-1-benzylpiperidine",50541-93-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/606C12ED-C8C8-4E86-A5B1-BDABB2292897,"NZ_CCID:
-Skin Irritation
-PHRASE: R 38 [Company Data]",,NZ_CCID,1,C1CN(CCC1N)CC2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/415852,PubChem,NC1CCN(Cc2ccccc2)CC1,Train,1,2702,training
-"NZ_CCID:
-1,4-Diazacycloheptane",,505-66-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/341E1177-F5E7-429E-8CE0-E9552DE03258,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 34/41[CHEMWATCH]",,NZ_CCID,1,C1CNCCNC1,https://pubchem.ncbi.nlm.nih.gov/compound/68163,PubChem,C1CNCCNC1,Train,1,2702,training
-"NZ_CCID:
-Propane, 2-bromo-2-methyl-","NZ_CCID:
-2-Bromo-2-methylpropane, 2-Bromoisobutane, Bromotrimethylmethane, Tertiarybutyl bromide, Trimethylbromomethane, t-Butyl bromide, tert-Butyl bromide",507-19-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9B7DFA90-5D62-4EDF-B207-FB5EE15388B0,"NZ_CCID:
-Skin Irritation
-SPECIES: Mouse
-RESULT: Irritating
-REFERENCE SOURCE: [KOSENKO AM; TOKSIKOL GIG PROD NEFTEKHIM NEFTEKHIM PROIZVOD VSES KONF (DOKL) 2ND: 108-10 (1972)]** [HSDB]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Irritating
-REFERENCE SOURCE: [KOSENKO AM; TOKSIKOL GIG PROD NEFTEKHIM NEFTEKHIM PROIZVOD VSES KONF (DOKL) 2ND: 108-10 (1972)]** [HSDB]",,NZ_CCID,1,CC(C)(C)Br,https://pubchem.ncbi.nlm.nih.gov/compound/10485,PubChem,CC(C)(C)Br,Train,1,2702,training
-"NZ_CCID:
-1,4-Dimethylpiperazine-2,5-dione","NZ_CCID:
-sarcosine anhydride",5076-82-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9B2BD012-587F-47DD-A362-912BDEC24E1C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CN1CC(=O)N(CC1=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/78761,PubChem,CN1CC(=O)N(C)CC1=O,Train,1,2702,training
-"NZ_CCID:
-2,5-Dichlorobenzoic acid",,50-79-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/90313C71-CB11-4104-BB9C-0ED1A82309F0,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C=C1Cl)C(=O)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/5784,PubChem,O=C(O)c1cc(Cl)ccc1Cl,Train,1,2702,training
-"NZ_CCID:
-2,4-Dichlorobenzoic acid",,50-84-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/05B5F113-6E88-4A1D-879A-CA03E543EE44,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C=C1Cl)Cl)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/5787,PubChem,O=C(O)c1ccc(Cl)cc1Cl,Train,1,2702,training
-"JP_CHRIP:
-Undecylbenzenesulfonic acid (C11)","JP_CHRIP:
-Undecylbenzenesulfonic acid",50854-94-9,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0334e.html,"JP_CHRIP:
-Based on the description in the report on human epidemiological studies (CERI-NITE Hazard Assessment No.5 (2005)): ""24 hour application of 1% aqueous solution of LAS induced moderate irritation."" The substance is thus considered a moderate irritant (LAS mixtures with carbon chain lengths of 10-14; no data available on undecylbenzenesulfonic acid per se).",,JP_CHRIP,1,CCCCCCCCCCCC1=CC=CC=C1S(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/172720,PubChem,CCCCCCCCCCCc1ccccc1S(=O)(=O)O,Train,1,2702,training
-"NZ_CCID:
-1-Chloroethyl chloroformate",,50893-53-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C6E8C92C-FFDE-49E8-A63F-ACBE63B0343A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CC(OC(=O)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/521305,PubChem,CC(Cl)OC(=O)Cl,Train,1,2702,training
-"EU_REACH:
-(3-chloropropyl)triethoxysilane",,5089-70-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14812/7/4/2/?documentUUID=4dfb4715-0a35-4f03-a770-4cbd445e39d1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](CCCCl)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/78771,PubChem,CCO[Si](CCCCl)(OCC)OCC,Train,1,2702,training
-"EU_REACH:
-N-[3-(triethoxysilyl)propyl]ethylenediamine",,5089-72-5,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24507/7/4/2/?documentUUID=79a09e06-adb6-45fb-8d65-49270784691c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](CCCNCCN)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/78772,PubChem,CCO[Si](CCCNCCN)(OCC)OCC,Train,1,2702,training
-"EU_REACH:
-2-(acryloyloxy)ethyl hydrogen succinate",,50940-49-3,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8819/7/4/2/?documentUUID=25776112-7770-40ef-89f3-d249b17c2d2c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CC(=O)OCCOC(=O)CCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/175956,PubChem,C=CC(=O)OCCOC(=O)CCC(=O)O,Test,1,2702,training
-"EU_REACH:
-α-phenyl-1H-benzimidazole-2-methanol",,50-97-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29444/7/4/2/?documentUUID=8ee2d3e2-b1f8-4831-b9f0-1473882e7221,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C(C2=NC3=CC=CC=C3N2)O,https://pubchem.ncbi.nlm.nih.gov/compound/5792,PubChem,OC(c1ccccc1)c1nc2ccccc2[nH]1,Train,1,2702,training
-"EU_REACH:
-3-(isotridecyloxy)propan-1-amine",,50977-10-1,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12334/7/4/2/?documentUUID=029eb227-f700-42be-84a4-64e5a315d443,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCCCCCCOCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/170945,PubChem,CC(C)CCCCCCCCCCOCCCN,Train,1,2702,training
-"EU_REACH:
-2,2'-[(3,3'-dichlorobiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis[N-(2,4-dimethylphenyl)-3-oxobutanamide]",,5102-83-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15893/7/4/2/?documentUUID=09de5216-3156-4fc0-9636-086e3d9ce645,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)NC(=O)C(C(=O)C)N=NC2=C(C=C(C=C2)C3=CC(=C(C=C3)N=NC(C(=O)C)C(=O)NC4=C(C=C(C=C4)C)C)Cl)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/73462,PubChem,CC(=O)C(N=Nc1ccc(-c2ccc(N=NC(C(C)=O)C(=O)Nc3ccc(C)cc3C)c(Cl)c2)cc1Cl)C(=O)Nc1ccc(C)cc1C,Train,1,2702,training
-"EU_REACH:
-2-ethylhexyl 10-ethyl-4-[[2-[(2-ethylhexyl)oxy]-2-oxoethyl]thio]-7-oxo-8-oxa-3,5-dithia-4-phosphatetradecanoate 4-oxide",,51032-53-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24335/7/4/2/?documentUUID=16cb53ff-2677-416b-be10-136e3fc85d1d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCOC(=O)CSP(SCC(=O)OCCCCCC(C)C)SCC(=O)OCCCCCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/166083,PubChem,CC(C)CCCCCOC(=O)CSP(SCC(=O)OCCCCCC(C)C)SCC(=O)OCCCCCC(C)C,Train,1,2702,training
-"EU_REACH:
-2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether
-
-JP_CHRIP:
-5-Propan-1-yl-6-(2,5,8-trioxadodecan-1-yl)-1,3-benzodioxole; Piperonyl Butoxide","JP_CHRIP:
-1,3-Benzodioxole, 5-[[2-(2-butoxyethoxy)ethoxy]methyl]-6-propyl-
-2-(2-Butoxyethoxy)ethyl 6-propylpiperonyl ether
-3,4-(Methylenedioxy)-6-propylbenzylbutyl diethyleneglycol ether
-5-2-(2-Butoxyethoxy)ethoxymethyl-6-propyl-1,3-benzodioxole
-alpha-2-(2-Butoxyethoxy)-ethoxy-4,5-methylenedioxy-2-propyltoluene
-Piperonyl butoxide",51-03-6,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10134/7/4/2/?documentUUID=0c6560f8-9e1c-4262-b23a-7d2b69f12b25
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0022e.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-[Rationale for the Classification]
-It was classified as ""Not classified"" from (1), (2).
-
-[Evidence Data]
-(1) It is reported that in a skin irritation test with rabbits (n = 6) (OECD TG 404, GLP, 72-hour observation), 4 animals showed very slight erythema but recovered within 24 hours (erythema/eschar score: 0/0/0/0/0/0, edema score: 0/0/0/0/0/0) (EU CLH report (2019), REACH registration dossier (Accessed Aug. 2020)).
-(2) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 3-day observation), no edema was seen in any animal. Very slight erythema was observed after 24 hours, and no skin reactions were found after 72 hours (erythema/eschar score: 0.7/0.3/0.3) (EU CLH report (2019), REACH registration dossier (Accessed Aug. 2020)).",Provided,"EU_REACH, JP_CHRIP",2,CCCCOCCOCCOCc1cc2OCOc2cc1CCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J25.378B,J-GLOBAL,CCCCOCCOCCOCc1cc2c(cc1CCC)OCO2,Train,1,2702,training
-"EU_REACH:
-2,3,4,9-tetrahydro-1H-carbazol-3-one",,51145-61-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17008/7/4/2/?documentUUID=56581857-0fe7-40ab-8a46-cc7bedd2d4c7,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC2=C(CC1=O)C3=CC=CC=C3N2,https://pubchem.ncbi.nlm.nih.gov/compound/10867037,PubChem,O=C1CCc2[nH]c3ccccc3c2C1,Train,1,2702,training
-"EU_REACH:
-5-[(4-bromo-2,6-difluorophenyl)difluoromethoxy]-1,2,3-trifluorobenzene",,511540-64-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26607/7/4/2/?documentUUID=779c0be3-ab5d-4e33-b9fa-bf03737cff00,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(C=C(C(=C1F)F)F)OC(C2=C(C=C(C=C2F)Br)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/21049705,PubChem,Fc1cc(OC(F)(F)c2c(F)cc(Br)cc2F)cc(F)c1F,Train,1,2702,training
-"NZ_CCID:
-Acryloyl morpholine",,5117-12-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7364CCED-F0B0-4A94-92B6-72B4FB24C366,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,C=CC(=O)N1CCOCC1,https://pubchem.ncbi.nlm.nih.gov/compound/98723,PubChem,C=CC(=O)N1CCOCC1,Train,1,2702,training
-"JP_CHRIP:
-2-chloro-2',6'-diethyl-N-(2-propoxyethyl)acetanilide [Pretilachlor]",,51218-49-6,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0147e.html,"JP_CHRIP:
-In a skin irritation test using rabbits, primary skin irritation index was 2.3 for the intact skin immediately after application and 24 hours later, and an average score of erythema was 1.5-2 (4 out of 6 animals) and a score of edema was less than 1 (4 out of 6 animals) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2007)). Based on these results, this substance was evaluated as moderately irritating (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2008), Japan crop protection association (Access on October 2016)).
-Therefore, it was classified in Category 2.",,JP_CHRIP,1,CCCOCCN(C(=O)CCl)c1c(CC)cccc1CC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.899F,J-GLOBAL,CCCOCCN(C(=O)CCl)c1c(CC)cccc1CC,Train,1,2702,training
-"EU_REACH:
-phenyl pent-4-enoate",,51231-09-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27392/7/4/2/?documentUUID=6fc57f3c-ff57-4b78-87ca-e06bc8c5650d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CCCC(=O)OC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/15255467,PubChem,C=CCCC(=O)Oc1ccccc1,Train,1,2702,training
-"EU_REACH:
-4-anilino-3-nitro-N-phenylbenzenesulfonamide",,5124-25-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10331/7/4/2/?documentUUID=b7313918-4e9d-4255-8959-8b160a27bc54,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC3=CC=CC=C3)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/21201,PubChem,O=[N+]([O-])c1cc(S(=O)(=O)Nc2ccccc2)ccc1Nc1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-Methylenebis(4,1-cyclohexylene) diisocyanate
-
-KR_NCIS:
-1,1'-Methylenebis[4-isocyanatocyclohexane]
-
-NZ_CCID:
-4,4'-Methylenedicyclohexyl diisocyanate","JP_CHRIP:
-4,4'-methylenedicyclohexyl diisocyanate (synonym:methylenebis(4,1-cyclohexylene) diisocyanate )
-Cyclohexane, 1,1'-methylenebis[4-isocyanato-
-Isocyanic acid, methylenedi-4,1-cyclohexylene ester
-methylenebis(1,4-cyclohexylene) diisocyanate
-Methylenebis(4,1-cyclohexylene) diisocyanate
-
-KR_NCIS:
-4,4'-Methylenedicyclohexyl diisocyanate
-
-NZ_CCID:
-Hydrogenated MDI, Isocyanic acid, methylenedi-4,1-cyclohexylene ester, Methylene bis(4-cyclohexylisocyanate)",5124-30-1,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2105e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8FEEFC35-9D15-490A-A4B2-100139845689","JP_CHRIP:
-In 2 skin irritation tests (OECD TG 404) with rabbits, since edema and erythema were observed, and primary irritation scores were 4.2 and 3.6, respectively, it was judged as moderate irritation (SIDS (2007)). In addition, although there are reports that severe skin irritation was observed in a skin irritation test with rabbits and that severe erythema and edema were observed in a skin irritation test with guinea pigs, there was no description of the recovery (ACGIH (7th, 2001)). Based on the results of tests according to the test guidelines as above, it was classified in Category 2. Information in SIDS (2007) was added, and the category was changed. Besides, this substance was classified in ""Xi; R38"" in the EU DSD classification, and in ""Skin Irrit. 2 H315"" in the EU CLP classification.
-
-NZ_CCID:
-Skin Irritation
-R-PHRASE: R 36/37/38 Irritating to eyes, respiratory system and skin. [IUCID 2000]
-Eye Irritation
-R-PHRASE: R 36/37/38 Irritating to eyes, respiratory system and skin. [IUCID 2000]",Provided,"JP_CHRIP, KR_NCIS, NZ_CCID",3,O=C=NC1CCC(CC2CCC(CC2)N=C=O)CC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J68.774J,J-GLOBAL,O=C=NC1CCC(CC2CCC(N=C=O)CC2)CC1,Train,1,2702,training
-"JP_CHRIP:
-Trimethyl phosphate
-
-NZ_CCID:
-Trimethyl phosphate
-
-US_HSDB:
-TRIMETHYL PHOSPHATE","JP_CHRIP:
-Phosphoric acid trimethyl ester",512-56-1,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0013e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/27770FB3-5ABB-4F99-B39B-084314D9628A
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/5090","JP_CHRIP:
-It was classified in Category 2 because it is described that it is a strong irritant to the skin (HSDB (2003)), and skin irritation rated 4 on a scale from 1 to 10 in a test with rabbits (GESTIS (Access on May 2012)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,COP(=O)(OC)OC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.617D,J-GLOBAL,COP(=O)(OC)OC,Train,1,2702,training
-"JP_CHRIP:
-2,4-Dinitrophenol
-
-NZ_CCID:
-Phenol, 2,4-dinitro- (wetted with not less than 15% water by mass)","JP_CHRIP:
-1-Hydroxy-2,4-dinitrobenzene
-Phenol, 2,4-dinitro-",51-28-5,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0412e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FEA86808-4D1C-4460-B547-BC70E17F7B49","JP_CHRIP:
-The substance is classified into Category 2 from the viewpoint of safety, based on the description in the report on guinea pig skin irritation tests (ATSDR (1995)): ""moderately irritating,"" though the results of rabbit skin irritation tests suggest the substance is ""mildly irritating"" (CERI Hazard Data 99-9 (2000)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES:
-RESULT: Severe irritant.
-REFERENCE SOURCE: Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989. Vol. II, p. 1454, #DUZ000. Information Handling Services. Material Safety Data Sheets Service. Microfiche Ed. Bimonthly Updates. December 1989/ January 1990. #5833-269, F-07. [NTP]
-Eye Irritation
-SPECIES:
-RESULT: Severe irritant.
-REFERENCE SOURCE: Sax, N.I. and Richard J. Lewis, Sr. Dangerous Properties of Industrial Materials. 7th Ed. Van Nostrand Reinhold. New York. 1989. Vol. II, p. 1454, #DUZ000. Information Handling Services. Material Safety Data Sheets Service. Microfiche Ed. Bimonthly Updates. December 1989/ January 1990. #5833-269, F-07. [NTP]",,"JP_CHRIP, NZ_CCID",2,Oc1ccc(cc1[N+](=O)[O-])[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.909G,J-GLOBAL,O=[N+]([O-])c1ccc(O)c([N+](=O)[O-])c1,Train,1,2702,training
-"EU_CLP:
-ditalimfos (ISO); O,O-diethyl phthalimidophosphonothioate",,5131-24-8,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCOP(=S)(N1C(=O)C2=CC=CC=C2C1=O)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/21207,PubChem,CCOP(=S)(OCC)N1C(=O)c2ccccc2C1=O,Test,1,2702,training
-"EU_REACH:
-isopropyl 2-bromo-2-methylpropionate",,51368-55-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13797/7/4/2/?documentUUID=fb1d7782-64fa-41e4-8904-9e42066ce885,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)OC(=O)C(C)(C)Br,https://pubchem.ncbi.nlm.nih.gov/compound/2796293,PubChem,CC(C)OC(=O)C(C)(C)Br,Train,1,2702,training
-"EU_REACH:
-dodecylphosphonic acid",,5137-70-2,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17216/7/4/2/?documentUUID=3fd7d818-6923-49ee-bd04-4e080e1e25f7,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCP(=O)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/78816,PubChem,CCCCCCCCCCCCP(=O)(O)O,Train,1,2702,training
-"NZ_CCID:
-2-Butanone, 3-hydroxy-","NZ_CCID:
-3-Hydroxy-2-butanone, Acetoin, Acetyl methyl carbinol, Dimethylketol, Methanol, acetylmethyl-",513-86-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/61AE6BD8-2B54-488F-A637-B19A65A2BEC5,"NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Moderate
-REFERENCE SOURCE: Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. (17,509,1979). [RTECS]
-Eye Irritation
-SPECIES:
-RESULT: May irritate or burn eyes.
-REFERENCE SOURCE: U.S. Department of Transportation. 1996 North American Emergency Response Guidebook. A Guidebook for First Responders During the Initial Phase of aHazardous Materials/Dangerous Goods Incident. U.S. Department of Transportation (U.S. DOT) Research and Special Programs Administration, Office of HazardousMaterials Initiatives and Training (DHM-50), Washington, D.C. (1996).,p. G-127]**QC REVIEWED** (HSDB)",,NZ_CCID,1,CC(C(=O)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/179,PubChem,CC(=O)C(C)O,Train,1,2702,training
-"NZ_CCID:
-1,1-Dichloroacetone",,513-88-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CF0401EC-E39F-401D-80D0-E26334A18D9F,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(=O)C(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10567,PubChem,CC(=O)C(Cl)Cl,Train,1,2702,training
-"EU_CLP:
-2-(1-methylpropyl)-4-tert-butylphenol",,51390-14-8,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCC(C)C1=C(C=CC(=C1)C(C)(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/526207,PubChem,CCC(C)c1cc(C(C)(C)C)ccc1O,Test,1,2702,training
-"EU_CLP:
-2-(diphosphonomethyl)succinic acid",,51395-42-7,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C(C(C(P(=O)(O)O)P(=O)(O)O)C(=O)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/189891,PubChem,O=C(O)CC(C(=O)O)C(P(=O)(O)O)P(=O)(O)O,Test,1,2702,training
-"NZ_CCID:
-(2-Chloro-1,1-dimethylethyl) benzene","NZ_CCID:
-neophyl chloride",515-40-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DB208525-6923-411B-BF0D-CB8EC8256CFA,"NZ_CCID:
-Skin Irritation
-PHRASE: R 38 [Company Data]",,NZ_CCID,1,CC(C)(CCl)C1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/68191,PubChem,CC(C)(CCl)c1ccccc1,Train,1,2702,training
-"EU_REACH:
-N-{5-[bis(2-methoxyethyl)amino]-2-[2-(2,6-dicyano-4-nitrophenyl)diazen-1-yl]phenyl}acetamide",,51553-03-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/9588/7/4/2/?documentUUID=a906ecfe-0076-485b-94fd-681143ff917a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)NC1=C(C=CC(=C1)N(CCOC)CCOC)N=NC2=C(C=C(C=C2C#N)[N+](=O)[O-])C#N,https://pubchem.ncbi.nlm.nih.gov/compound/165341294,PubChem,COCCN(CCOC)c1ccc(N=Nc2c(C#N)cc([N+](=O)[O-])cc2C#N)c(NC(C)=O)c1,Train,1,2702,training
-"EU_REACH:
-pyridin-3-yl N,N-dimethylcarbamate",,51581-32-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21055/7/4/2/?documentUUID=4b3a38a9-ca42-4dad-8b38-30cdc6f25d20,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C)C(=O)OC1=CN=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/98821,PubChem,CN(C)C(=O)Oc1cccnc1,Train,1,2702,training
-"NZ_CCID:
-2-Acetyl-gamma-butyrolactone","NZ_CCID:
-2-acetylbutyrolactone",517-23-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/069F34EE-9275-4FA6-BF9C-A2AADBD1EE9C,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 36/ 37/ 38. [Company data]
-Eye Irritation
-R-PHRASE: R 36/ 37/ 38. [Company data]",,NZ_CCID,1,CC(=O)C1CCOC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/10601,PubChem,CC(=O)C1CCOC1=O,Train,1,2702,training
-"JP_CHRIP:
-Bis(2-chloroethyl)methylamine; Nitrogen mustard","JP_CHRIP:
-2,2'-Dichloro-N-methyldiethylamine
-2-Chloro-N-(2-chloroethyl)-N-methylethanamine
-Bis(2-chloroethyl)methylamine
-Chlormethine
-Ethanamine, 2-chloro-N-(2-chloroethyl)-N-methyl-
-HN 2
-HN2
-Nitrogen mustard
-Nitrogen mustard (HN 2)",51-75-2,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/07-mhlw-0043e.html,"JP_CHRIP:
-It brings about a strong vesicant action on the skin and is corrosive (Patty 5th, 2001). As refined categorization is difficult, we determined that the substance is classified between Category 1A and 1C.",,JP_CHRIP,1,CN(CCCl)CCCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.305A,J-GLOBAL,CN(CCCl)CCCl,Train,1,2702,training
-"EU_REACH:
-triethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane",,51851-37-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24656/7/4/2/?documentUUID=686f2289-e401-4eed-bc61-4ef6306bba63,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](CCC(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/103991,PubChem,CCO[Si](CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)(OCC)OCC,Train,1,2702,training
-"EU_REACH:
-3-hydroxy-4-{[2-methoxy-5-methyl-4-(methylsulfamoyl)phenyl]diazenyl}-N-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-2-naphthamide",,51920-12-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11429/7/4/2/?documentUUID=afd9cfd5-48dc-44ab-b272-6697c39de1e2,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1S(=O)(=O)NC)OC)N=NC2=C(C(=CC3=CC=CC=C32)C(=O)NC4=CC5=C(C=C4)NC(=O)N5)O,https://pubchem.ncbi.nlm.nih.gov/compound/104012,PubChem,CNS(=O)(=O)c1cc(OC)c(N=Nc2c(O)c(C(=O)Nc3ccc4[nH]c(=O)[nH]c4c3)cc3ccccc23)cc1C,Train,1,2702,training
-"EU_REACH:
-4-[(oxiran-2-yl)methoxy]-9H-carbazole",,51997-51-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19696/7/4/2/?documentUUID=3cd8212c-f16d-42ec-b723-8e6abc036800,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C(O1)COC2=CC=CC3=C2C4=CC=CC=C4N3,https://pubchem.ncbi.nlm.nih.gov/compound/5020710,PubChem,c1ccc2c(c1)[nH]c1cccc(OCC3CO3)c12,Train,1,2702,training
-"AU_HCIS:
-α, α,α,4-tetrachlorotoluene
-
-JP_CHRIP:
-p-(Trichloromethyl)chlorobenzene (p-Chlorobenzotrichloride)","AU_HCIS:
-p-chlorobenzotrichloride
-Benzene, 1-chloro-4-(trichloromethyl)-
-
-JP_CHRIP:
-p-Chlorobenzotrichloride",5216-25-1,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4373
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2034e.html","JP_CHRIP:
-[Rationale for the Classification]
-(2) corresponds to ""Not classified"" (Category 3 in UN GHS classification). As for (1), though the information on 72 hours after patch removal is unknown, it is judged that it is severely irritating. So, Category 2 is considered appropriate. Because both (1) and (2) are highly reliable data, Category 2 with the higher hazard was adopted.
-
-[Evidence Data]
-(1) It was reported that in 4-hour semi-occlusive application in a skin irritation test (OECD TG 404, GLP-compliant, n=3) with rabbits, the erythema score was 1.0 and the edema score was 0.43 at 14-day after patch removal, but scores up to 72 hours after patch removal were not reported. In the test report, it was judged to be severely irritating (REACH registration dossier (Accessed Dec. 2018)).
-(2) It is reported that in 4-hour occlusive application of a skin irritation test (OECD TG 404, GLP-compliant, n=3) with rabbits, the erythema and edema scores were around 1 at 24, 48 and 72 hours after patch removal but that the erythema score was 1 and the edema score was 0 even after 15 days (REACH registration dossier (Accessed Dec. 2018)).
-
-[Reference Data, etc.]
-(3) It is classified in Skin Irrit. 2 in EU CLP.",Provided,"AU_HCIS, JP_CHRIP",2,Clc1ccc(cc1)C(Cl)(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J38.180B,J-GLOBAL,Clc1ccc(C(Cl)(Cl)Cl)cc1,Train,1,2702,training
-"EU_REACH:
-4-amino-2,5-dimethoxy-N-phenylbenzene-1-sulfonamide",,52298-44-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5217/7/4/2/?documentUUID=55570535-2d41-4199-a57d-ea280c78d48a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC(=C(C=C1N)OC)S(=O)(=O)NC2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/104143,PubChem,COc1cc(S(=O)(=O)Nc2ccccc2)c(OC)cc1N,Train,1,2702,training
-"NZ_CCID:
-2-Propenoic acid, 2-cyano-3,3-diphenyl-, ethyl ester",,5232-99-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E62F2092-34D5-47D6-A564-D908F88BA336,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,CCOC(=O)C(=C(C1=CC=CC=C1)C2=CC=CC=C2)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/243274,PubChem,CCOC(=O)C(C#N)=C(c1ccccc1)c1ccccc1,Train,1,2702,training
-"EU_REACH:
-1,3-bis[3-(dimethylamino)propyl]urea",,52338-87-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26695/7/4/2/?documentUUID=8fffcd74-c35c-4388-84fa-f7d60bfe6f29,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C)CCCNC(=O)NCCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/104163,PubChem,CN(C)CCCNC(=O)NCCCN(C)C,Train,1,2702,training
-"EU_REACH:
-2-hydroxy-3-{4-[2-hydroxy-3-(prop-2-enoyloxy)propoxy]butoxy}propyl prop-2-enoate",,52408-42-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26069/7/4/2/?documentUUID=8182a2ca-566b-4d23-8a0c-71749ae45957,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CC(=O)OCC(COCCCCOCC(COC(=O)C=C)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/103631,PubChem,C=CC(=O)OCC(O)COCCCCOCC(O)COC(=O)C=C,Train,1,2702,training
-"EU_CLP:
-ethyl-2-chloro-2,2-diphenylacetate",,52460-86-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCOC(=O)C(C1=CC=CC=C1)(C2=CC=CC=C2)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/240547,PubChem,CCOC(=O)C(Cl)(c1ccccc1)c1ccccc1,Test,1,2702,training
-"EU_REACH:
-4-[3,5-difluoro-4-(trifluoromethoxy)phenyl]-3-fluoro-4'-[(1s,4r)-4-propylcyclohexyl]-1,1'-biphenyl",,524709-77-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23124/7/4/2/?documentUUID=2325e4d2-01a4-40fe-bf8c-642f221c8c07,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2=CC=C(C=C2)C3=CC(=C(C=C3)C4=CC(=C(C(=C4)F)OC(F)(F)F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/20736014,PubChem,CCCC1CCC(c2ccc(-c3ccc(-c4cc(F)c(OC(F)(F)F)c(F)c4)c(F)c3)cc2)CC1,Train,1,2702,training
-"NZ_CCID:
-2-(Diphenylboryloxy) ethylamine",,524-95-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2538396E-BBBE-416C-A77D-A061295F16B1,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,B(C1=CC=CC=C1)(C2=CC=CC=C2)OCCN,https://pubchem.ncbi.nlm.nih.gov/compound/1598,PubChem,NCCOB(c1ccccc1)c1ccccc1,Train,1,2702,training
-"EU_CLP:
-bronopol (INN); 2-bromo-2-nitropropane-1,3-diol",,52-51-7,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C(C(CO)([N+](=O)[O-])Br)O,https://pubchem.ncbi.nlm.nih.gov/compound/2450,PubChem,O=[N+]([O-])C(Br)(CO)CO,Test,1,2702,training
-"NZ_CCID:
-1,6-Naphthalenedisulphonic acid",,525-37-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C7C50307-86F2-4D33-A746-AEBB3773836E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC2=C(C=CC(=C2)S(=O)(=O)O)C(=C1)S(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/10676,PubChem,O=S(=O)(O)c1ccc2c(S(=O)(=O)O)cccc2c1,Train,1,2702,training
-"EU_REACH:
-2-[N-(2-cyanoethyl)-4-[(2,6-dichloro-4-nitrophenyl)azo]anilino]ethyl acetate",,5261-31-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20199/7/4/2/?documentUUID=447e2b8f-c84b-4853-b590-8fe49d5cafa1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)OCCN(CCC#N)C1=CC=C(C=C1)N=NC2=C(C=C(C=C2Cl)[N+](=O)[O-])Cl,https://pubchem.ncbi.nlm.nih.gov/compound/78916,PubChem,CC(=O)OCCN(CCC#N)c1ccc(N=Nc2c(Cl)cc([N+](=O)[O-])cc2Cl)cc1,Train,1,2702,training
-"EU_REACH:
-D-Glucitol, propoxylated",,52625-13-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15106/7/4/2/?documentUUID=4120e57b-12a6-4dfd-8147-f8ae0debe5ff,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CO)COCC(C(C(C(COCCCO)OCCCO)OCCCO)OCCCO)OCCCO,https://pubchem.ncbi.nlm.nih.gov/compound/171178,PubChem,OCCCOCC(OCCCO)C(OCCCO)C(OCCCO)C(COCCCO)OCCCO,Train,1,2702,training
-"EU_REACH:
-N-(2-carboxyethyl)-N-octyl-β-alanine",,52663-87-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23413/7/4/2/?documentUUID=726d5f67-b460-481f-baa7-2ebfbd69caca,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCN(CCC(=O)O)CCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/104276,PubChem,CCCCCCCCN(CCC(=O)O)CCC(=O)O,Train,1,2702,training
-"EU_REACH:
-O,O,S-tris(4-aminophenyl) thiophosphate",,52664-35-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11228/7/4/2/?documentUUID=8661678d-4e9d-4b83-919d-4b8c7203d6ce,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1N)OP(=S)(OC2=CC=C(C=C2)N)OC3=CC=C(C=C3)N,https://pubchem.ncbi.nlm.nih.gov/compound/104278,PubChem,Nc1ccc(OP(=S)(Oc2ccc(N)cc2)Oc2ccc(N)cc2)cc1,Train,1,2702,training
-"EU_REACH:
-2,4-dioxo-3-oxatricyclo[7.3.1.0⁵,¹³]trideca-1(13),5,7,9,11-pentaene-8,10-dicarboxylic acid",,52671-72-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7325/7/4/2/?documentUUID=2199c64b-fd7c-45ca-a9d8-4db6a617cf49,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C2C(=CC=C3C2=C1C(=O)OC3=O)C(=O)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/132336,PubChem,O=C(O)c1ccc2c3c(ccc(C(=O)O)c13)C(=O)OC2=O,Train,1,2702,training
-"JP_CHRIP:
-2.3-xylenol; 2,3-Dimethylphenol
-
-KR_NCIS:
-2,3-Dimethylphenol
-
-NZ_CCID:
-Phenol, 2,3-dimethyl-","JP_CHRIP:
-Phenol, 2,3-dimethyl-
-2,3-Xylenol
-
-KR_NCIS:
-1,2-Dimethyl-3-hydroxybenzene; 1-Hydroxy-2,3-dimethylbenzene; 2,3-Xylenol; o-Xylenol; Phenol, 2,3-dimethyl-; XYLENOL
-
-NZ_CCID:
-1-Hydroxy-2,3-dimethylbenzene, 2,3-Xylenol, o-Xylenol",526-75-0,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2029e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C19B6F91-12D5-4EEE-9AB5-533FAA07979E","JP_CHRIP:
-[Rationale for the Classification]
-Based on (1) and (2), it was classified in Category 1. Besides, since new data were obtained, the category was changed.
-
-[Evidence Data]
-(1) This substance is potentially corrosive to the skin and eyes (NICNAS IMAP (Access on August 2019)).
-(2) It was classified in ""Skin Corr. 1B (H314)"" in EU-CLP classification (EU CLP classification (Access on June 2019)).
-
-[Reference Data, etc.]
-(3) In an in vitro skin irritation test using the Human Dermal Epithelial Model (EpiDerm) according to OECD TG 439, this substance was classified as an irritant (REACH registration dossier (Access on July 2019)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [N-CLASS]
-Eye Irritation
-SPECIES:
-RESULT: Corrosive
-REFERENCE SOURCE: Lenga, Robert E. The Sigma-Aldrich Library of Chemical Safety Data. Edition 1. Sigma-Aldrich Corporation. Milwaukee, WI. 1985. p. 790, #D. [NTP]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,Cc1cccc(O)c1C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J6.663J,J-GLOBAL,Cc1cccc(O)c1C,Train,1,2702,training
-"NZ_CCID:
-D-Gluconic acid",,526-95-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E61C2FDC-9C86-4D12-B59D-ADEAB3B92782,,,NZ_CCID,1,C([C@H]([C@H]([C@@H]([C@H](C(=O)O)O)O)O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/10690,PubChem,O=C(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO,Train,1,2702,training
-"EU_REACH:
-N-[2-[(2-bromo-4,6-dinitrophenyl)azo]-5-(diethylamino)phenyl]acetamide",,52697-38-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20204/7/4/2/?documentUUID=cce48161-d0a1-47d3-ab14-8e7eacd4065a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(CC)C1=CC(=C(C=C1)N=NC2=C(C=C(C=C2Br)[N+](=O)[O-])[N+](=O)[O-])NC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/104287,PubChem,CCN(CC)c1ccc(N=Nc2c(Br)cc([N+](=O)[O-])cc2[N+](=O)[O-])c(NC(C)=O)c1,Train,1,2702,training
-"EU_REACH:
-L-xylo-hex-2-ulosonic acid",,526-98-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2059/7/4/2/?documentUUID=707cf8b1-ec2e-4ba5-8332-4403df6dcbdc,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C([C@@H]([C@H]([C@@H](C(=O)C(=O)O)O)O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/102424,PubChem,O=C(O)C(=O)[C@@H](O)[C@H](O)[C@@H](O)CO,Train,1,2702,training
-"NZ_CCID:
-Thiophene-2-carboxylic acid chloride","NZ_CCID:
-2-thiophenecarbonyl chloride",5271-67-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5E72CDD5-8DE0-4D1B-BE66-5B57BE72E85E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CSC(=C1)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/78928,PubChem,O=C(Cl)c1cccs1,Train,1,2702,training
-"AU_HCIS:
-3,6,9,12-Tetraoxatetracosan-1-ol",,5274-68-0,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6497,,,AU_HCIS,1,CCCCCCCCCCCCOCCOCCOCCOCCO,https://pubchem.ncbi.nlm.nih.gov/compound/78933,PubChem,CCCCCCCCCCCCOCCOCCOCCOCCO,Train,1,2702,training
-"NZ_CCID:
-2-Furoyl chloride",,527-69-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4ADFAAB5-DDA5-4412-8390-E1F1113DF68B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=COC(=C1)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/68242,PubChem,O=C(Cl)c1ccco1,Train,1,2702,training
-"EU_REACH:
-N-[5-chloro-2-(methoxyacetyl)phenyl]acetamide",,52793-11-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12637/7/4/2/?documentUUID=2b1d70dd-5a10-48da-81db-02c8b1cad62b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)CC(=O)NC1=C(C=CC(=C1)Cl)OC,https://pubchem.ncbi.nlm.nih.gov/compound/98791,PubChem,COc1ccc(Cl)cc1NC(=O)CC(C)=O,Train,1,2702,training
-"EU_REACH:
-3,3'-{(2,5-dimethyl-1,4-phenylene)bis[imino(1,3-dioxobutane-2,1-diyl)diazene-2,1-diyl]}bis[4-chloro-N-(5-chloro-2-methylphenyl)benzamide]",,5280-80-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5928/7/4/2/?documentUUID=d327b0f2-c4e1-4f68-b69e-b64fc7ac7a4f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)Cl)NC(=O)C2=CC(=C(C=C2)Cl)N=NC(C(=O)C)C(=O)NC3=CC(=C(C=C3C)NC(=O)C(C(=O)C)N=NC4=C(C=CC(=C4)C(=O)NC5=C(C=CC(=C5)Cl)C)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/110639,PubChem,CC(=O)C(N=Nc1cc(C(=O)Nc2cc(Cl)ccc2C)ccc1Cl)C(=O)Nc1cc(C)c(NC(=O)C(N=Nc2cc(C(=O)Nc3cc(Cl)ccc3C)ccc2Cl)C(C)=O)cc1C,Train,1,2702,training
-"EU_REACH:
-L-cysteine",,52-90-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12475/7/4/2/?documentUUID=341aa702-5506-4ea0-a5ed-6f6ab5e45f4d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C([C@@H](C(=O)O)N)S,https://pubchem.ncbi.nlm.nih.gov/compound/5862,PubChem,N[C@@H](CS)C(=O)O,Train,1,2702,training
-"NZ_CCID:
-4-(4-Nitrophenylazo)-1-Naphthol",,5290-62-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/29968CC2-910A-4112-80F4-150242AA9A04,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C2C(=C1)C(=CC=C2O)N=NC3=CC=C(C=C3)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/79174,PubChem,O=[N+]([O-])c1ccc(N=Nc2ccc(O)c3ccccc23)cc1,Train,1,2702,training
-"NZ_CCID:
-2-Tolunitrile","NZ_CCID:
-o-Tolunitrile",529-19-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0A3A559E-511D-4D80-9AC6-A3C8EC47C343,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 38. [Company data]",,NZ_CCID,1,CC1=CC=CC=C1C#N,https://pubchem.ncbi.nlm.nih.gov/compound/10721,PubChem,Cc1ccccc1C#N,Train,1,2702,training
-"NZ_CCID:
-t-Butyl bromoacetate","NZ_CCID:
-Tert-butyl bromoacetate",5292-43-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2D4BCA0F-D764-435F-816C-0EAD5EE5D7AC,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(C)(C)OC(=O)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/79177,PubChem,CC(C)(C)OC(=O)CBr,Train,1,2702,training
-"EU_REACH:
-(2R)-2-(2-chlorophenyl)-2-hydroxyacetic acid",,52950-18-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12970/7/4/2/?documentUUID=68a4e2f5-495a-45ba-9689-fcc051eaec58,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=C1)[C@H](C(=O)O)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/2733641,PubChem,O=C(O)[C@H](O)c1ccccc1Cl,Train,1,2702,training
-"EU_REACH:
-1-butoxy-3-(prop-2-en-1-yloxy)propan-2-ol",,53146-45-5,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19633/7/4/2/?documentUUID=57d6a5cd-ae60-44a1-84ad-3f4309d56af4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOCC(COCC=C)O,https://pubchem.ncbi.nlm.nih.gov/compound/13805865,PubChem,C=CCOCC(O)COCCCC,Test,1,2702,training
-"AU_HCIS:
-1-Docosanamine, N-docosyl-",,53171-44-1,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5778,,,AU_HCIS,1,CCCCCCCCCCCCCCCCCCCCCCNCCCCCCCCCCCCCCCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/104422,PubChem,CCCCCCCCCCCCCCCCCCCCCCNCCCCCCCCCCCCCCCCCCCCCC,Train,1,2702,training
-"EU_REACH:
-Bis-4-(hydroxybenzoyl)hydrochinone",,53201-62-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1039/7/4/2/?documentUUID=a1a0d961-086d-4e19-9b20-0d4063445120,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1C(=O)OC2=CC=C(C=C2)OC(=O)C3=CC=C(C=C3)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/11035492,PubChem,O=C(Oc1ccc(OC(=O)c2ccc(O)cc2)cc1)c1ccc(O)cc1,Train,1,2702,training
-"EU_REACH:
-1-[({[(tetradecyloxy)carbonyl]peroxy}carbonyl)oxy]tetradecane",,53220-22-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5940/7/4/2/?documentUUID=2aff888a-e1f8-45b2-8f3d-52b8ed8ef41e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCOC(=O)OOC(=O)OCCCCCCCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/104447,PubChem,CCCCCCCCCCCCCCOC(=O)OOC(=O)OCCCCCCCCCCCCCC,Train,1,2702,training
-"JP_CHRIP:
-2-chloroacetophenone","JP_CHRIP:
-2-Chloro-1-phenylethanone
-2-chloro-1-phenylethanone (synonym:omega-chloroacetophenone)
-alpha-Chloroacetophenone
-Ethanone, 2-chloro-1-phenyl-
-omega-Chloroacetophenone
-Phenacyl chloride",532-27-4,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2070e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified in Category 2 from (1) - (5).
-
-[Evidence Data]
-(1) Regardless of the animal species, primary contact dermatitis was marked and persistent with this substance. In addition to producing more marked erythema, edema, and desquamation, inflammation extended beyond the original area of application (ACGIH (7th, 2001)).
-(2) This substance is irritating to the skin and can cause severe chemical burns (second and third degree) (IRIS (1991)).
-(3) This substance is irritating to the skin and respiratory tract in humans, and contact with the skin causes erythema and pain (Environmental Risk Assessment for Chemical Substances vol. 6, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2008)).
-(4) It causes moderate to severe irritation to the skin and has a potential to sensitize the skin (GESTIS (Access on May 2020)).
-(5) Primary irritant dermatitis was observed at high concentrations in range-finding studies in 7 volunteers for patch testing, and the reactions resolved within 1 week, but hyperpigmentation was seen at the application sites (HSDB (Access on May 2020)).
-
-[Reference Data, etc.]
-(6) Following application of solutions (0.5 mL) of this substance in trioctyl phosphate to the skin of rabbits (2 animals) for 30 minutes, mean primary irritation scores were 4.0 (unwashed) for a 1% solution, and 5.5 (unwashed), 5.2 (washed), or 2.9 (washed with water and soap) for a 4% solution (HSDB (Access on May 2020)).
-(7) As a result of application of a 12.5% solution of this substance in acetone or corn oil to the skin of rabbits, guinea pigs, or rats for 6 hours, depending on the species, slight to moderate erythema and slight to marked edema were observed at the end but disappeared completely between 7 and 14 days. On days 4-7, mild to marked desquamation was observed in rats and guinea pigs, Between day 1 and 7, ecchymoses and scattered necrotic areas were found in rabbits, followed by scar tissue formation. In all species, lesions extended beyond the original area of application (HSDB (Access on May 2020)).",,JP_CHRIP,1,ClCC(=O)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.629H,J-GLOBAL,O=C(CCl)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-Mandelonitrile",,532-28-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AE743D45-79CA-4A62-A524-C55607570F92,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)C(C#N)O,https://pubchem.ncbi.nlm.nih.gov/compound/10758,PubChem,N#CC(O)c1ccccc1,Train,1,2702,training
-"EU_REACH:
-1,2-bis(2-propylheptyl) benzene-1,2-dicarboxylate",,53306-54-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14145/7/4/2/?documentUUID=0feef1e5-379c-4c38-94be-be802b0bc552,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCC(CCC)COC(=O)C1=CC=CC=C1C(=O)OCC(CCC)CCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/92344,PubChem,CCCCCC(CCC)COC(=O)c1ccccc1C(=O)OCC(CCC)CCCCC,Train,1,2702,training
-"NZ_CCID:
-1H-Isoindole-1,3(2H)-dione, 2-(bromomethyl)-","NZ_CCID:
-N-(bromomethyl)phthalimide, N-Bromomethylphthalimide",5332-26-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E627C807-58FC-46D2-B6BF-9BEDB08EFA10,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 34. [Company data]
-Eye Irritation
-R-PHRASE: R 34. [Company data]",,NZ_CCID,1,C1=CC=C2C(=C1)C(=O)N(C2=O)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/79244,PubChem,O=C1c2ccccc2C(=O)N1CBr,Train,1,2702,training
-"EU_REACH:
-3-methoxypropan-1-amine
-
-JP_CHRIP:
-3-Methoxypropylamine
-
-NZ_CCID:
-3-Methoxypropylamine","JP_CHRIP:
-3-methoxypropylamine",5332-73-0,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13449/7/4/2/?documentUUID=af1c6f7c-7cdb-44f6-96f3-bd5d53771b63
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0112e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5E41F732-2FED-48F4-849D-5B1939855E55","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-In the test using 6 rabbits (OECD TG404, GLP-compliant), burns were noted in all animals tested after 1 hour of patch removal. Symptoms of severe erythema were not disappeared completely in 14 days, and the PII (primary skin irritation index) was 6.67 (maximum score was 8) (ECETOC TR 66 (1995)). Based on the document, the substance was classified as Category 1.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 35 [Company Data]
-Eye Irritation
-R PHRASE: R 35 [Company Data]",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,COCCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.072D,J-GLOBAL,COCCCN,Train,1,2702,training
-"EU_REACH:
-2-octyldodecan-1-ol",,5333-42-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5814/7/4/2/?documentUUID=58f61241-8d3f-4abf-a439-77960dc8434f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCC(CCCCCCCC)CO,https://pubchem.ncbi.nlm.nih.gov/compound/21414,PubChem,CCCCCCCCCCC(CO)CCCCCCCC,Train,1,2702,training
-"NZ_CCID:
-2-Iodophenol",,533-58-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/690201CA-6D8D-4787-A365-4C6BA337FEBD,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)O)I,https://pubchem.ncbi.nlm.nih.gov/compound/10784,PubChem,Oc1ccccc1I,Train,1,2702,training
-"NZ_CCID:
-Ethyl 2-bromobutyrate",,533-68-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CB00F0C4-4840-428F-9EED-ED34B1253174,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCC(C(=O)OCC)Br,https://pubchem.ncbi.nlm.nih.gov/compound/79039,PubChem,CCOC(=O)C(Br)CC,Train,1,2702,training
-"EU_REACH:
-2-hydroxycyclohepta-2,4,6-trien-1-one",,533-75-5,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24770/7/4/2/?documentUUID=ff2488c2-39ac-4d21-9b11-1213206d2f5f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=O)C=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/10789,PubChem,O=c1cccccc1O,Train,1,2702,training
-"NZ_CCID:
-1,3-Dichloroacetone",,534-07-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/95E9D4FC-C483-4F44-A3CD-1973170521A0,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(C(=O)CCl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10793,PubChem,O=C(CCl)CCl,Train,1,2702,training
-"EU_REACH:
-pentane-1,2-diol",,5343-92-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2101/7/4/2/?documentUUID=c1fb70bd-aec9-43bb-992f-1551c54bb5e9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC(CO)O,https://pubchem.ncbi.nlm.nih.gov/compound/93000,PubChem,CCCC(O)CO,Train,1,2702,training
-"JP_CHRIP:
-4,6-Dinitro-o-cresol
-
-KR_NCIS:
-DNOC
-
-NZ_CCID:
-4,6-Dinitro-o-cresol
-
-US_HSDB:
-4,6-Dinitro-o-cresol","JP_CHRIP:
-2,4-Dinitro-ortho-cresol
-2-Methyl-4,6-dinitrophenol
-4,6-Dinitro-o-cresol
-4,6-Dinitro-ortho-cresol
-DNOC
-Phenol, 2-methyl-4,6-dinitro-
-
-KR_NCIS:
-2-Methyl-4,6-dinitrophenol; 4,6-Dinitro-o-cresol
-
-NZ_CCID:
-Arborol, Degrassan, Dekrysil, Detal, Dillex, Dinitro, Dinitrocresol, Dinitrodendtroxal, Dinitrol, Dinitro-o-cresol, Dinoc, Dinurania, Ditrosol, 2,4-Dinitro-6-methylphenol, 2,4-Dinitro-o-cresol, 2-Methyl-4,6-dinitrophenol, 3,5-Dinitro-2-hydroxytoluene, 6-Methyl-2,4-dinitrophenol, Antinonin, Antinonnin, Effusan, Elgetol, Elipol, Extrar, Hedolit, Hedolite, Kreozan, Krezotol 50, Lipan, Nitrofan, o-Cresol, 4,6-dinitro-, Phenol, 2-methyl-4,6-dinitro-, Prokarbol, Rafex, Rafex 35, Raphatox, Sandolin, Selinon, Sinox, Winterwash",534-52-1,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2005e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CA03A1CE-6AF7-4945-A207-F80D7B59971E
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1596","JP_CHRIP:
-[Rationale for the Classification]
-It was classified in Category 2 from (1) - (4).
-
-[Evidence Data]
-(1) This substance is irritating to the human skin, and contact with the skin causes yellow staining of the skin (Environmental Risk Assessment for Chemical Substances vol. 10 (Ministry of the Environment, 2012)).
-(2) In a skin irritation test by 4-hour semi-occlusive application of this substance (0.5 g) to the rabbit skin, erythema and slight edema occurred, indicative of an irritative effect (EHC 220 (2000), GESTIS (Access on April 2020)).
-(3) This substance causes irritation through corrosion to the eye and irritation to the skin. And it has the potential to sensitize the skin (GESTIS (Access on April 2020)).
-(4) This substance causes edema in the rabbit skin and is corrosive to the rabbit eye (EHC 220 (2000)).
-
-[Reference Data, etc.]
-(5) It was classified in Skin Irrit. 2 (H315) in EU CLP classification (EU CLP classification (Access on May 2020)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]
-Eye Irritation
-R PHRASE: R 41 [ECB]",,"JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",4,Cc1cc(cc(c1O)[N+](=O)[O-])[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.289A,J-GLOBAL,Cc1cc([N+](=O)[O-])cc([N+](=O)[O-])c1O,Train,1,2702,training
-"EU_REACH:
-3-(diethylamino)propanenitrile",,5351-04-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19251/7/4/2/?documentUUID=4ac1d52a-f87d-4454-8450-006945293a81,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(CC)CCC#N,https://pubchem.ncbi.nlm.nih.gov/compound/79306,PubChem,CCN(CC)CCC#N,Train,1,2702,training
-"NZ_CCID:
-Ethyl 2-bromopropionate",,535-11-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/73734077-9C44-4F98-AA8B-3EC16D24B22A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCOC(=O)C(C)Br,https://pubchem.ncbi.nlm.nih.gov/compound/79040,PubChem,CCOC(=O)C(C)Br,Train,1,2702,training
-"NZ_CCID:
-Ethyl dichloroacetate",,535-15-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3D1332F5-28B3-4EA3-8C48-90C4E51977E5,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCOC(=O)C(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10808,PubChem,CCOC(=O)C(Cl)Cl,Train,1,2702,training
-"EU_REACH:
-propyl (2S)-2-hydroxypropanoate",,53651-69-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5435/7/4/2/?documentUUID=9c552395-e3e9-49da-842c-dac2e9279b2e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCOC(=O)[C@H](C)O,https://pubchem.ncbi.nlm.nih.gov/compound/2734942,PubChem,CCCOC(=O)[C@H](C)O,Test,1,2702,training
-"NZ_CCID:
-4-Ethylpyridine",,536-75-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/878B7A02-AF34-4723-9AA2-4D584F8C9099,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCC1=CC=NC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/10822,PubChem,CCc1ccncc1,Train,1,2702,training
-"EU_REACH:
-(2E)-1,1,4,4-tetramethoxybut-2-ene; (2Z)-1,1,4,4-tetramethoxybut-2-ene",,5370-08-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10544/7/4/2/?documentUUID=27004e75-eb3c-4116-b535-e934bed2bee8,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(/C=C\C(OC)OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/5382783,PubChem,COC(/C=C\C(OC)OC)OC,Train,1,2702,training
-"EU_REACH:
-1,4-dimethyl 2-aminobenzene-1,4-dicarboxylate",,5372-81-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10651/7/4/2/?documentUUID=1ee301bb-d209-4ea1-a89b-18c13fd3d58c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=CC(=C(C=C1)C(=O)OC)N,https://pubchem.ncbi.nlm.nih.gov/compound/79336,PubChem,COC(=O)c1ccc(C(=O)OC)c(N)c1,Train,1,2702,training
-"NZ_CCID:
-4-Piperidinol","NZ_CCID:
-4-hydroxypiperidine",5382-16-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/ACDEFCB9-173F-4580-B38E-2C1BE13B94AF,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1CNCCC1O,https://pubchem.ncbi.nlm.nih.gov/compound/79341,PubChem,OC1CCNCC1,Train,1,2702,training
-"JP_CHRIP:
-Isobutylbenzene","JP_CHRIP:
-Benzene, (2-methylpropyl)-",538-93-2,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0113e.html,"JP_CHRIP:
-Clear erythema and slight edema observed in a test applied 0.5 mL to rabbits for 4 hours (OECD TG 404) recovered in 8 days after application, and it was assessed as moderately irritating (IUCLID (2000)).
-On the basis of the assessment, it was classified in Category 2.",Provided,JP_CHRIP,1,CC(C)Cc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J43.442F,J-GLOBAL,CC(C)Cc1ccccc1,Train,1,2702,training
-"AU_HCIS:
-Citral
-
-JP_CHRIP:
-citral
-
-NZ_CCID:
-Citral","AU_HCIS:
-2,6-Octadienal, 3,7-dimethyl-
-
-JP_CHRIP:
-2,6-Octadienal,3,7-dimethyl-
-3,7-Dimethyl-2,6 octadienal
-citral
-Lemonal
-
-NZ_CCID:
-3,7-Dimethyl-2,6-octadienal, Lemsyn GB",5392-40-5,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1025
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0132e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/735AA40D-AEED-42D8-98D8-1708F2B355E6","JP_CHRIP:
-In a 24-hour exposure test, the substance was moderately to markedly irritating to skin in rabbits, and caused moderate erythema and edema (SIDS (accessed in August 2008)). The substance is rated R38 (equivalent to Category 2 or 3) in the EU classification. Although it is reported that in humans, 1 to 8% solutions (unknown solvent) produced no irritation after 48-hour application, when 1, 4, 8% in petrolatum was applied for 24 hours, 8% in petrolatum was slightly irritating (SIDS (accessed in August 2008)). Therefore, the substance was classified into Category 2.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Human
-RESULT: The irritant effects of 19 oils and 20 synthetic perfumes used in cosmetics were tested on the skin of animals and 50 male volunteers. Results showed that skin sensitivity decreased in the following order: rabbit, guinea pig, rat, man, and miniature swine. Of the 20 oils tested, 2 hydrocarbons (hexadecane and pristane) proved to be severely irritating to human skin; the rest were moderately or mildly irritating. Citral and geraniol at 32% concentration were the most irritating of the perfumes in the human patch test.
-REFERENCE SOURCE: Motoyoshi et al 1979 Comparative studies on the irritancy of oils and synthetic perfumes to the skin of rabbit, guinea pig, rat, miniature swine and man Cosmet. Toiletries; VOL 94 ISS Aug 1979, P41-48, (REF 4) [toxline]
-R-PHRASE: R 38 Irritating to skin. [iuclid 2000]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CC(=CCCC(=CC=O)C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.073B,J-GLOBAL,CC(C)=CCCC(C)=CC=O,Train,1,2702,training
-"NZ_CCID:
-Furanacrylic acid",,539-47-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/66C76231-98F7-48C3-80EB-D09D2FD06AD7,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,C1=COC(=C1)/C=C/C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/643402,PubChem,O=C(O)/C=C/c1ccco1,Train,1,2702,training
-"EU_REACH:
-3-(carbamimidoylsulfanyl)propanoic acid",,5398-29-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24619/7/4/2/?documentUUID=201e1ea2-6a6b-4371-961e-68fbd30fa720,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CSC(=N)N)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/79387,PubChem,N=C(N)SCCC(=O)O,Train,1,2702,training
-"EU_REACH:
-N-(4-fluorophenyl)-2-hydroxy-N-(propan-2-yl)acetamide",,54041-17-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5900/7/4/2/?documentUUID=7511f357-e818-4b98-9fda-81a578302a6d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)N(C1=CC=C(C=C1)F)C(=O)CO,https://pubchem.ncbi.nlm.nih.gov/compound/6452934,PubChem,CC(C)N(C(=O)CO)c1ccc(F)cc1,Train,1,2702,training
-"EU_REACH:
-453-570-1",,540734-22-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16947/7/4/2/?documentUUID=da0e002c-2336-400c-89e1-ee417b824b41,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H]1C=CCC([C@H]1C(=O)OC)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/12082923,PubChem,COC(=O)[C@H]1[C@H](C)C=CCC1(C)C,Train,1,2702,training
-"JP_CHRIP:
-Ethyl chloroformate
-
-NZ_CCID:
-Ethoxycarbonyl chloride","JP_CHRIP:
-Carbonochloridic acid ethyl ester
-Chloroformic acid ethyl ester
-Ethoxycarbonyl chloride
-Ethyl chlorocarbonate
-Ethyl chloroformate
-
-NZ_CCID:
-Carbonochloridic acid, ethyl ester, Cathyl chloride, Chloroformic acid ethyl ester, Ethyl carbonochloridate, Ethyl chlorocarbonate, Ethyl chloroformate, Formic acid, chloro-, ethyl ester",541-41-3,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0055e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C67FA5C4-4399-4235-A750-200AE8E16057","JP_CHRIP:
-Based on reports of ""a strong skin irritant"" (HSDB (2003)) and ""causes severe skin burns"" (HSDB (2003)) as human health effects, and classification as C; R34 in EU classification (EU-Annex I (2009)), the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CCOC(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J53.980E,J-GLOBAL,CCOC(=O)Cl,Train,1,2702,training
-"NZ_CCID:
-5-Bromovaleronitrile",,5414-21-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F604E00E-DC77-46D2-AEDC-87CEC3EB677B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(CCBr)CC#N,https://pubchem.ncbi.nlm.nih.gov/compound/79435,PubChem,N#CCCCCBr,Train,1,2702,training
-"NZ_CCID:
-3,3-Dimethylacrylic acid",,541-47-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2CDA4ED1-0474-4559-875D-C7372F121D38,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 36 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 38 [CHEMWATCH]",,NZ_CCID,1,CC(=CC(=O)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/10931,PubChem,CC(C)=CC(=O)O,Train,1,2702,training
-"JP_CHRIP:
-m-Dichlorobenzene","JP_CHRIP:
-1,3-Dichlorobenzene
-Benzene, 1,3-dichloro-
-m-Phenylene dichloride
-meta-Dichlorobenzene",541-73-1,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0081e.html,"JP_CHRIP:
-There are descriptions that this substance is irritating to the skin and causes erythema and pain on contact with the skin (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)). From the above, this substance was classified in Category 2. Besides, it is reported that strong irritation occurred after 24-hour occlusive application of this substance in a skin irritation test with rabbits (DFGOT vol. 1(1991)). However, it was not used for this classification as it is the result of 24-hour application.",,JP_CHRIP,1,Clc1cccc(Cl)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.641G,J-GLOBAL,Clc1cccc(Cl)c1,Train,1,2702,training
-"NZ_CCID:
-Chloroacetic anhydride",,541-88-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A7246949-7604-4AC7-88D9-8D4408C18CA4,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C(C(=O)OC(=O)CCl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10946,PubChem,O=C(CCl)OC(=O)CCl,Train,1,2702,training
-"EU_REACH:
-6-methyl-1,3,5-triazine-2,4-diamine",,542-02-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11626/7/4/2/?documentUUID=c3d477b9-6076-4e25-bdea-23dd5b389c6f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=NC(=NC(=N1)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/10949,PubChem,Cc1nc(N)nc(N)n1,Train,1,2702,training
-"EU_REACH:
-propan-2-yl 3-oxobutanoate",,542-08-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12824/7/4/2/?documentUUID=80a48004-e6ef-4a1e-8c8c-a4b8e8e11c45,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)OC(=O)CC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/68329,PubChem,CC(=O)CC(=O)OC(C)C,Train,1,2702,training
-"NZ_CCID:
-3-Chloropropionitrile",,542-76-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/913E5CFB-3BC6-42D6-8922-56368AEE6018,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(CCl)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/10963,PubChem,N#CCCCl,Train,1,2702,training
-"JP_CHRIP:
-Cyclopentadiene","JP_CHRIP:
-cyclopentadiene
-Cyclopentadiene; Cyclopentadiene
-Pentole
-Pyropentylene",542-92-7,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2025e.html,"JP_CHRIP:
-[Rationale for the Classification]
-Based on (1), it was classified in Category 2. Besides, the category was changed due to the new data obtained.
-
-[Evidence Data]
-(1) This substance caused contact dermatitis and sensitization (PATTY (6th, 2012)).",,JP_CHRIP,1,C1C=CC=C1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.603I,J-GLOBAL,C1=CCC=C1,Train,1,2702,training
-"EU_REACH:
-2-(undec-10-enamido)acetic acid",,54301-26-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8859/7/4/2/?documentUUID=6a8356e3-14f0-48d0-a659-94a462568e2c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CCCCCCCCCC(=O)NCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/10037355,PubChem,C=CCCCCCCCCC(=O)NCC(=O)O,Train,1,2702,training
-"NZ_CCID:
-Succinyl dichloride","NZ_CCID:
-succinyl chloride",543-20-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8E08612C-7F06-48FE-AEFC-8D633553FB1E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(CC(=O)Cl)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10970,PubChem,O=C(Cl)CCC(=O)Cl,Train,1,2702,training
-"NZ_CCID:
-Isobutylchlorofomate","NZ_CCID:
-Isobutyl Chloroformate",543-27-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/89500115-A486-40F5-B200-8F637AE97B15,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 34. [MSDS]
-Eye Irritation
-R-PHRASE: R 34. [MSDS]",,NZ_CCID,1,CC(C)COC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/62365,PubChem,CC(C)COC(=O)Cl,Train,1,2702,training
-"EU_REACH:
-3,5,5-trimethylhexanal
-
-JP_CHRIP:
-3,5,5-Trimethylhexanal","JP_CHRIP:
-3,5,5-trimethylhexanal
-Hexanal, 3,5,5-trimethyl-; 3,5,5-Trimethylhexanal; 3,5,5-Trimethylhexanal",5435-64-3,Cat 2,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1150/7/4/2/?documentUUID=f2b4e014-0014-49b5-b0bd-bb708d6653e7
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0040e.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-On the basis of ""irritating"" in a semi-occlusive test applied a nonyl aldehyde mixture containing 90% of this substance to rabbit skins (OECD TG404, GLP) (IUCLID (2000)) and ""moderately irritating"" in a test applied this substance for 24 hours (HSDB (2009)), it was classified in Category 2.",Provided,"EU_REACH, JP_CHRIP",2,CC(CC=O)CC(C)(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J64.760H,J-GLOBAL,CC(CC=O)CC(C)(C)C,Train,1,2702,training
-"NZ_CCID:
-Benzyl bromoacetate","NZ_CCID:
-benzyl 2-bromoacetate",5437-45-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/757C0457-2134-4158-8B69-0BAF02A47A23,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)COC(=O)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/62576,PubChem,O=C(CBr)OCc1ccccc1,Train,1,2702,training
-"EU_REACH:
-N-[4-(methoxyacetyl)phenyl]acetamide",,5437-98-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20955/7/4/2/?documentUUID=d9217ed1-7d4e-4c22-8787-e7c1dc511ab4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)CC(=O)NC1=CC=C(C=C1)OC,https://pubchem.ncbi.nlm.nih.gov/compound/21576,PubChem,COc1ccc(NC(=O)CC(C)=O)cc1,Test,1,2702,training
-"NZ_CCID:
-6-Methyl-2-heptylamine","NZ_CCID:
-1,5-dimethylhexylamine",543-82-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5EA815DC-8C0A-4FDA-B22C-FB5D1307A030,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CC(C)CCCC(C)N,https://pubchem.ncbi.nlm.nih.gov/compound/10982,PubChem,CC(C)CCCC(C)N,Train,1,2702,training
-"NZ_CCID:
-4-Ethylcyclohexanone",,5441-51-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/36F27559-7108-4E6A-A24D-33550F5AE53E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CCC1CCC(=O)CC1,https://pubchem.ncbi.nlm.nih.gov/compound/79506,PubChem,CCC1CCC(=O)CC1,Train,1,2702,training
-"NZ_CCID:
-1,3,5-Cycloheptatriene","NZ_CCID:
-cycloheptatriene",544-25-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CE94D13E-2C88-4F67-A974-E8F2847D5D91,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1C=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/11000,PubChem,C1=CC=CCC=C1,Train,1,2702,training
-"NZ_CCID:
-Butane, 1,1'-thiobis-",,544-40-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B2C606FF-DEF8-459A-B279-31D9E180C270,,,NZ_CCID,1,CCCCSCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/11002,PubChem,CCCCSCCCC,Train,1,2702,training
-"EU_REACH:
-2-ethylhexyl benzoate",,5444-75-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11596/7/4/2/?documentUUID=6dbc323d-1661-453b-a5d9-3fc4bc32aeeb,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)C1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/94310,PubChem,CCCCC(CC)COC(=O)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-Methyl 2-bromopropionate",,5445-17-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C846A67E-2927-457C-90A1-FB4FD16A3B36,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(C(=O)OC)Br,https://pubchem.ncbi.nlm.nih.gov/compound/95576,PubChem,COC(=O)C(C)Br,Train,1,2702,training
-"NZ_CCID:
-Hexadecane
-
-US_HSDB:
-n-Hexadecane","NZ_CCID:
-n-Hexadecane",544-76-3,Cat 2,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3E4A0CB9-3588-47C5-B667-9BB674112CBF
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/6854","NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]",,"NZ_CCID, US_HSDB",2,CCCCCCCCCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/11006,PubChem,CCCCCCCCCCCCCCCC,Train,1,2702,training
-"EU_REACH:
-2-butoxyethyl benzoate",,5451-76-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23065/7/4/2/?documentUUID=c75d4750-0420-4862-9801-bc08a8d830d3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOCCOC(=O)C1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/79543,PubChem,CCCCOCCOC(=O)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-Cyclooctylamine",,5452-37-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C808354F-3026-4F1B-8931-75AFF05C634D,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1CCCC(CCC1)N,https://pubchem.ncbi.nlm.nih.gov/compound/2903,PubChem,NC1CCCCCCC1,Train,1,2702,training
-"EU_REACH:
-ethane-1,2-diyl bis(3-oxobutanoate)",,5459-04-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10689/7/4/2/?documentUUID=756f3927-2d90-43fc-b167-947872cd8876,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)CC(=O)OCCOC(=O)CC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/79566,PubChem,CC(=O)CC(=O)OCCOC(=O)CC(C)=O,Train,1,2702,training
-"ChemSkin:
-2-Ethylhexyl 4-methoxycinnamate (octinoxate)",,5466-77-3,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,CCCCC(CC)COC(=O)/C=C/C1=CC=C(C=C1)OC,https://pubchem.ncbi.nlm.nih.gov/compound/5355130,PubChem,CCCCC(CC)COC(=O)/C=C/c1ccc(OC)cc1,Test,1,2702,training
-"JP_CHRIP:
-Propylene glycol monoethyl ether acetate","JP_CHRIP:
-1-Ethoxy-2-acetoxypropanol
-1-Ethoxy-2-propanol acetate
-1-Ethoxy-2-propyl acetate
-2-Propanol, 1-ethoxy-, acetate
-2PG1EEA",54839-24-6,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0046e.html,"JP_CHRIP:
-It is reported that it had a low potential of irritancy in a test with rabbits (OECD TG404, GLP) (ECETOC TR95 vol. II (2005)). And it is described that the test results showed slight erythema in two out of three animals and slight edema in one, but it could not be evidence to classify this substance as an irritant (IUCLID (2000)). Therefore, it was classified as ""Not classified"" in the Classification JIS (corresponding to Category 3 in UN GHS classification).",Provided,JP_CHRIP,1,CCOCC(C)OC(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J38.100D,J-GLOBAL,CCOCC(C)OC(C)=O,Train,1,2702,training
-"NZ_CCID:
-Cyclohexanemethanamine, 1,3,3-trimethyl-N-(2-methylpropylidene)-5-[(2-methylpropylidene)amino]-",,54914-37-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0F97A48F-694B-4C7A-B682-4A3A954ED436,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34[CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CC(C)C=NCC1(CC(CC(C1)(C)C)N=CC(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/108265,PubChem,CC(C)C=NCC1(C)CC(N=CC(C)C)CC(C)(C)C1,Train,1,2702,training
-"EU_REACH:
-2-isopropyl-9H-thioxanthen-9-one",,5495-84-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24945/7/4/2/?documentUUID=89ee4e28-abf8-4cd7-a101-f6adc4be883c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1=CC2=C(C=C1)SC3=CC=CC=C3C2=O,https://pubchem.ncbi.nlm.nih.gov/compound/79633,PubChem,CC(C)c1ccc2sc3ccccc3c(=O)c2c1,Train,1,2702,training
-"EU_CLP:
-3-methyl-5-phenylpentan-1-al",,55066-49-4,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(CCC1=CC=CC=C1)CC=O,https://pubchem.ncbi.nlm.nih.gov/compound/108313,PubChem,CC(CC=O)CCc1ccccc1,Test,1,2702,training
-"US_HSDB:
-Acitretin",,55079-83-9,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/7187,,,US_HSDB,1,CC1=CC(=C(C(=C1/C=C/C(=C/C=C/C(=C/C(=O)O)/C)/C)C)C)OC,https://pubchem.ncbi.nlm.nih.gov/compound/5284513,PubChem,COc1cc(C)c(/C=C/C(C)=C/C=C/C(C)=C/C(=O)O)c(C)c1C,Train,1,2702,training
-"NZ_CCID:
-Benzene, 1-chloro-2-(chloromethyl)-3-fluoro-",,55117-15-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B02E55D3-F4FB-4409-8FF0-B04405664011,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC(=C(C(=C1)Cl)CCl)F,https://pubchem.ncbi.nlm.nih.gov/compound/108675,PubChem,Fc1cccc(Cl)c1CCl,Train,1,2702,training
-"EU_REACH:
-1-(chloromethyl)-2-methylbenzene",,552-45-4,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21327/7/4/2/?documentUUID=bdf30469-2cbd-4ac4-8869-fc231d901b09,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=CC=C1CCl,https://pubchem.ncbi.nlm.nih.gov/compound/11093,PubChem,Cc1ccccc1CCl,Train,1,2702,training
-"NZ_CCID:
-Tropic acid",,552-63-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/37750F05-998D-4713-81C8-20DE5AA2C489,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C(C=C1)C(CO)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/10726,PubChem,O=C(O)C(CO)c1ccccc1,Train,1,2702,training
-"EU_REACH:
-4-[(1-butyl-5-cyano-2-hydroxy-4-methyl-6-oxo-1,6-dihydropyridin-3-yl)diazenyl]-N-(2-ethylhexyl)benzenesulfonamide",,55290-62-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16345/7/4/2/?documentUUID=d4eda543-8b6b-46f8-becf-ab7125503350,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)CNS(=O)(=O)C1=CC=C(C=C1)N=NC2=C(C(=C(N(C2=O)CCCC)O)C#N)C,https://pubchem.ncbi.nlm.nih.gov/compound/108330,PubChem,CCCCC(CC)CNS(=O)(=O)c1ccc(N=Nc2c(C)c(C#N)c(O)n(CCCC)c2=O)cc1,Train,1,2702,training
-"EU_REACH:
-5-[(2-hydroxyethyl)amino]-2-methylphenol",,55302-96-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21638/7/4/2/?documentUUID=72ff3e96-c526-48b3-ac07-07d1963e2433,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)NCCO)O,https://pubchem.ncbi.nlm.nih.gov/compound/134396,PubChem,Cc1ccc(NCCO)cc1O,Train,1,2702,training
-"EU_REACH:
-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one",,55314-16-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33471/7/4/2/?documentUUID=b6336d22-9280-45d2-b196-243a7cbed105,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C)/C=C/C(=O)C1=CN=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/5369165,PubChem,CN(C)/C=C/C(=O)c1cccnc1,Train,1,2702,training
-"NZ_CCID:
-Acetylsalicyloyl chloride",,5538-51-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0371D7CC-5795-4C58-B816-B371C5647974,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(=O)OC1=CC=CC=C1C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/79668,PubChem,CC(=O)Oc1ccccc1C(=O)Cl,Train,1,2702,training
-"EU_REACH:
-2,3-dihydro-1-benzofuran-2-one",,553-86-6,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2122/7/4/2/?documentUUID=3672c489-c6f8-4f1e-af9a-eae644844935,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C2=CC=CC=C2OC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/68382,PubChem,O=C1Cc2ccccc2O1,Test,1,2702,training
-"AU_HCIS:
-Ethanedioic acid, dimethyl ester
-
-EU_REACH:
-dimethyl oxalate",,553-90-2,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5156
-EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25766/7/4/2/?documentUUID=aa814c37-8c63-43d7-bb3b-18068359a978","EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,"AU_HCIS, EU_REACH",2,COC(=O)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/11120,PubChem,COC(=O)C(=O)OC,Train,1,2702,training
-"EU_REACH:
-2,4-dichloroaniline",,554-00-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1683/7/4/2/?documentUUID=9fe60766-330f-44a1-a18b-4c11617daf16,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C=C1Cl)Cl)N,https://pubchem.ncbi.nlm.nih.gov/compound/11123,PubChem,Nc1ccc(Cl)cc1Cl,Train,1,2702,training
-"NZ_CCID:
-Propanoic acid, methyl ester","NZ_CCID:
-Methyl propionate, Methyl propylate",554-12-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/539085EE-6792-4F1D-8F8F-80A58EB638F7,"NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Moderate
-REFERENCE SOURCE: (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-(20,765,1982)] [RTECS]
-Eye Irritation
-EXPERT JUDGEMENT: Assume
-Eye Irritation as it is a skin irritant. Both the ethyl and butyl ester are eye irritants.",,NZ_CCID,1,CCC(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/11124,PubChem,CCC(=O)OC,Train,1,2702,training
-"EU_REACH:
-(2S,3S,4R)-2-aminooctadecane-1,3,4-triol",,554-62-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27327/7/4/2/?documentUUID=817df8db-6f46-4e25-b78c-8acaa1820b96,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCC[C@H]([C@H]([C@H](CO)N)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/122121,PubChem,CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO,Train,1,2702,training
-"AU_HCIS:
-Phenol, 3-nitro-
-
-NZ_CCID:
-3-Nitrophenol","NZ_CCID:
-m-nitrophenol",554-84-7,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6823
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/40E8689F-90DE-410E-A986-1E6F00B30028","NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,"AU_HCIS, NZ_CCID",2,C1=CC(=CC(=C1)O)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/11137,PubChem,O=[N+]([O-])c1cccc(O)c1,Train,1,2702,training
-"EU_REACH:
-1,3-bis(octadecanoyloxy)propan-2-yl octadecanoate",,555-43-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12757/7/4/2/?documentUUID=9faef1d4-5f6a-4b66-a62f-1ce425d895f9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCCC(=O)OCC(COC(=O)CCCCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/11146,PubChem,CCCCCCCCCCCCCCCCCC(=O)OCC(COC(=O)CCCCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCCCC,Train,1,2702,training
-"AU_HCIS:
-2,3-epoxypropan-1-ol
-
-JP_CHRIP:
-2,3-Epoxy-1-propanol
-
-KR_NCIS:
-Glycidol
-
-NZ_CCID:
-Glycidol","AU_HCIS:
-glycidol
-oxiranemethanol
-2-hydroxymethyloxirane
-1-hydroxy-2,3-epoxypropane
-1,2-epoxy-3-hydroxypropane
-
-JP_CHRIP:
-2,3-Epoxy-1-propanol
-2,3-Epoxy-1-propanol
-2,3-Epoxypropan-1-ol
-3-Hydroxypropylene oxide
-Glycide
-Glycidol
-Oxirane methanol
-Oxiranemethanol
-
-KR_NCIS:
-Oxiranemethanol",556-52-5,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1853
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2074e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/514D99A8-220E-45BE-B203-4BD003444E70","JP_CHRIP:
-Based on results of ""moderately irritating"" (ACGIH (2001), PATTY (5th, 2001)) and irritation score of 4.5 (maximal value: 8.0) (PATTY (5th, 2001)) in a rabbit test, the substance was classified into Category 2. In EU classification, the substance is classified into Xi; R36/37/38 (EU-Annex I (access on May 2009)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]
-Eye Irritation
-R PHRASE: R 36 [ECB]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID",4,OCC1CO1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.660C,J-GLOBAL,OCC1CO1,Train,1,2702,training
-"EU_CLP:
-3-iodpropene; allyl iodide",,556-56-9,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C=CCI,https://pubchem.ncbi.nlm.nih.gov/compound/11166,PubChem,C=CCI,Test,1,2702,training
-"EU_CLP:
-methyl isothiocyanate",,556-61-6,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CN=C=S,https://pubchem.ncbi.nlm.nih.gov/compound/11167,PubChem,CN=C=S,Test,1,2702,training
-"EU_REACH:
-2,2'-[(3,3'-dichlorobiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutanamide]",,5567-15-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16028/7/4/2/?documentUUID=b35fe108-0379-4819-aa3d-a9f969d9755b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC(=C(C=C1OC)Cl)OC)N=NC2=C(C=C(C=C2)C3=CC(=C(C=C3)N=NC(C(=O)C)C(=O)NC4=CC(=C(C=C4OC)Cl)OC)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/21733,PubChem,COc1cc(NC(=O)C(N=Nc2ccc(-c3ccc(N=NC(C(C)=O)C(=O)Nc4cc(OC)c(Cl)cc4OC)c(Cl)c3)cc2Cl)C(C)=O)c(OC)cc1Cl,Train,1,2702,training
-"JP_CHRIP:
-3-Methyl-2-buten-1-ol","JP_CHRIP:
-3,3-Dimethylallyl alcohol
-Prenol
-Prenyl alcohol",556-82-1,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0038e.html,"JP_CHRIP:
-It was classified in Category 1 because the primary dermal irritation index (PDII) was 6.13, and it was judged as corrosive in a test by a 4-hour occlusive application of 0.5 mL of undiluted this substance to the rabbit skin (SIDS (2003)). Besides, it is reported that it was also judged as corrosive in another test by a 20-hour or 24-hour occlusive application of undiluted this substance to the rabbit skin (SIDS (2003)).",,JP_CHRIP,1,CC(=CCO)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J11.528B,J-GLOBAL,CC(C)=CCO,Train,1,2702,training
-"EU_REACH:
-2-(4-tert-butyl-3-hydroxy-2,6-dimethylphenyl)acetonitrile",,55699-10-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11381/7/4/2/?documentUUID=c41c1835-d02b-4eec-8ff2-9b01f8b03d29,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C(=C1CC#N)C)O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/108756,PubChem,Cc1cc(C(C)(C)C)c(O)c(C)c1CC#N,Train,1,2702,training
-"NZ_CCID:
-2-s-Butylaniline","NZ_CCID:
-2-Sec-butylaniline",55751-54-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5C536735-57F1-46DB-BA89-CC4FF0B7988D,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 38. [Company data]
-Eye Irritation
-R-PHRASE: R 36. [Company data]",,NZ_CCID,1,CCC(C)C1=CC=CC=C1N,https://pubchem.ncbi.nlm.nih.gov/compound/108358,PubChem,CCC(C)c1ccccc1N,Train,1,2702,training
-"NZ_CCID:
-2-(4-Methoxyphenyl)-ethylamine","NZ_CCID:
-4-methoxyphenethylamine",55-81-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D591C631-C379-45FF-AE46-18E6E5DF361C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,COC1=CC=C(C=C1)CCN,https://pubchem.ncbi.nlm.nih.gov/compound/4657,PubChem,COc1ccc(CCN)cc1,Train,1,2702,training
-"JP_CHRIP:
-carbon tetrabromide
-
-NZ_CCID:
-Carbon tetrabromide","JP_CHRIP:
-Carbon tetrabromide
-
-NZ_CCID:
-Methane, tetrabromide, Methane, tetrabromo-, Tetrabromomethane",558-13-4,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0835e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/80A5BE3E-2F92-4B29-8431-A10E30D8C2B4","JP_CHRIP:
-Since it was indicated that the effect which suggested the stimulativeness of degrees from very mild to moderate was admitted as a result of the skin irritation study in a rabbit on PATTY (4th, 1994), it was judged with Category 2.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,"JP_CHRIP, NZ_CCID",2,BrC(Br)(Br)Br,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.667K,J-GLOBAL,BrC(Br)(Br)Br,Train,1,2702,training
-"JP_CHRIP:
-Methanesulfonyl fluoride",,558-25-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0166e.html,"JP_CHRIP:
-From the information that it is extremely destructive to tissues of skin (HSDB (2007)), it was classified in Category 1.",,JP_CHRIP,1,CS(=O)(=O)F,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J6.487D,J-GLOBAL,CS(=O)(=O)F,Train,1,2702,training
-"EU_REACH:
-1-[2-(2-butoxy-1-methylethoxy)-1-methylethoxy]propan-1-ol",,55934-93-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13383/7/4/2/?documentUUID=c7095db4-c017-4906-b798-cc23a834d752,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOCCCC(C)OCCOCC(C)CO,https://cactus.nci.nih.gov/chemical/structure/55934-93-5/smiles,CACTUS,CCOCCCC(C)OCCOCC(C)CO,Train,1,2702,training
-"EU_REACH:
-(2E)-2-methyl-3-(4-methylphenyl)prop-2-en-1-ol",,56138-10-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26852/7/4/2/?documentUUID=e2e3cb19-19c4-43ca-8c58-bceb2fa3206e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)/C=C(\C)/CO,https://pubchem.ncbi.nlm.nih.gov/compound/15683411,PubChem,C/C(=C\c1ccc(C)cc1)CO,Train,1,2702,training
-"EU_REACH:
-Cyclopentyl methyl ether",,5614-37-9,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26626/7/4/2/?documentUUID=897a895f-954e-4ea5-99fd-bb9c75c7582a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1CCCC1,https://pubchem.ncbi.nlm.nih.gov/compound/138539,PubChem,COC1CCCC1,Train,1,2702,training
-"JP_CHRIP:
-3,3'-Iminodi(propylamine)
-
-KR_NCIS:
-3,3'-Iminodi(propylamine)","JP_CHRIP:
-Imino-bis(3-propylamine)",56-18-8,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0188e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP:
-Since a solution of this substance has a pH of 12 (100 g/L, 20 degC) (GESTIS (access on Sep. 2009)) and the substance is classified into C; R35 in EU classification (EU-Annex I (access on Sep. 2009)), the substance was classified into Category 1. As relevant information, there is a report of ""moderate"" irritating in an open irritation test where 470 mg of the substance was applied to the skin of rabbits (RTECS (1999)).",,"JP_CHRIP, KR_NCIS",2,NCCCNCCCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J9.891D,J-GLOBAL,NCCCNCCCN,Train,1,2702,training
-"JP_CHRIP:
-Carbon tetrachloride
-
-NZ_CCID:
-Carbon tetrachloride","JP_CHRIP:
-Carbon tetrachloride
-Carbon_tetrachloride
-methane, tetrachloro-
-Perchloromethane
-Tetra
-Tetrachlorocarbon
-
-NZ_CCID:
-Benzinoform, Carbon chloride (CCl4), Flukoids, Methane, tetrachloro-, Necatorina, Perchloromethane, R10, Tetrachloromethane, Tetrafinol, Tetraform, Tetrasol, Univerm, Vermoestricid",56-23-5,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2089e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FB458AA9-92B1-40A0-BBBB-56E074561FC2","JP_CHRIP:
-Following application of 1.5 mL of carbon tetrachloride to human forearm skin for 5 minutes, slight and transient erythema was observed after 10 - 20 minutes (Initial Risk Assessment Report (NITE, CERI, NEDO) (2005)). There are reports of ""moderately irritating"" results in skin irritation tests using rabbits and guinea pigs (Hazard Assessment Report (CERI, NITE) (2006)). Based on the data, the substance was classified into Category 2.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Human
-RESULT: Direct dermal contact with undiluted carbon tetrachloride causes a mild burning sensation with mild erythema (Stewart and Dodd 1964). Some individuals appear to be hypersensitive, developing marked swelling, itching, and blisters following dermal contact (Taylor 1925).
-REFERENCE SOURCE: [ATSDR]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Mild
-REFERENCE SOURCE: [INCHEM]",,"JP_CHRIP, NZ_CCID",2,ClC(Cl)(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.317E,J-GLOBAL,ClC(Cl)(Cl)Cl,Train,1,2702,training
-"ChemSkin:
-3,3-Dimethylpentane",,562-49-2,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,CCC(C)(C)CC,https://pubchem.ncbi.nlm.nih.gov/compound/11229,PubChem,CCC(C)(C)CC,Test,1,2702,training
-"AU_HCIS:
-N,N'-methylenedimorpholine","AU_HCIS:
-Morpholine, 4,4'-methylenebis-
-N,N'methylenebismorpholine
-[formaldehyde released from N,N'-methylenebismorpholine]
-[MBM]",5625-90-1,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5717,,,AU_HCIS,1,C1COCCN1CN2CCOCC2,https://pubchem.ncbi.nlm.nih.gov/compound/21839,PubChem,C1CN(CN2CCOCC2)CCO1,Train,1,2702,training
-"JP_CHRIP:
-3-Chloro-2-methyl-1-propene","JP_CHRIP:
-3-Chloro-2-methyl-1-propene
-1-Propene, 3-chloro-2-methyl-
-3-Chloro-2-methyl-1-propene
-3-Chloro-2-methylpropene
-gamma-Chloroisobutylene
-Methallyl chloride
-Methyl allyl chloride",563-47-3,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0113e.html,"JP_CHRIP:
-It is reported to be corrosive to rabbit skin (DFGOT vol. 4 (1992)), and it is also reported to be irritating to the skin in humans (Environmental Risk Assessment for Chemical Substances Vol. 9 (Ministry of the Environment, 2011)). Therefore, it was classified in Category 1.",,JP_CHRIP,1,CC(=C)CCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.671I,J-GLOBAL,C=C(C)CCl,Train,1,2702,training
-"EU_REACH:
-N-(2-ethylhexyl)-1-[[3-methyl-4-[(3-methylphenyl)azo]phenyl]azo]naphthalen-2-amine",,56358-10-2,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24345/7/4/2/?documentUUID=815b01ff-ca6e-420e-97a7-14b53f5cd2ab,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)CNC1=C(C2=CC=CC=C2C=C1)N=NC3=CC(=C(C=C3)N=NC4=CC=CC(=C4)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/171514,PubChem,CCCCC(CC)CNc1ccc2ccccc2c1N=Nc1ccc(N=Nc2cccc(C)c2)c(C)c1,Train,1,2702,training
-"NZ_CCID:
-2-Bromopropionyl bromide",,563-76-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9E5388E5-43E4-429F-AD7C-8867292D50D3,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 34. [Chemwatch]
-Eye Irritation
-R-PHRASE: R 34/ 41. [Chemwatch]",,NZ_CCID,1,CC(C(=O)Br)Br,https://pubchem.ncbi.nlm.nih.gov/compound/79047,PubChem,CC(Br)C(=O)Br,Train,1,2702,training
-"JP_CHRIP:
-Isopropyl methyl ketone","JP_CHRIP:
-2-Acetyl propane
-3-Methyl-2-butanone
-Methyl isopropyl ketone",563-80-4,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0103e.html,"JP_CHRIP:
-This substance was classified in Category 2 based on a description that it is irritating to human skin (HSDB (Access on August 2015)). Besides, there is a report that as a result of application of this substance (undiluted) to rabbits for 24 hours, moderate irritation was observed (PATTY (6th, 2012)), and there is another report that the application of this substance (undiluted) to guinea pigs for 24 hours resulted in moderate irritation, and after 24 hours, edema and necrosis were observed (PATTY (6th, 2012)). However, these were not adopted for the classification because they are 24-hour application tests.",,JP_CHRIP,1,CC(C)C(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J43.513I,J-GLOBAL,CC(=O)C(C)C,Train,1,2702,training
-"EU_REACH:
-4-[[5-(anilino)carbonyl-2-methoxyphenyl]azo]-3-hydroxynaphthalene-2-carboxamide",,56396-10-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24090/7/4/2/?documentUUID=5f0943af-e22c-4bbc-b5a4-c12790c8eea4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2)N=NC3=C(C(=CC4=CC=CC=C43)C(=O)N)O,https://pubchem.ncbi.nlm.nih.gov/compound/91836,PubChem,COc1ccc(C(=O)Nc2ccccc2)cc1N=Nc1c(O)c(C(N)=O)cc2ccccc12,Train,1,2702,training
-"EU_REACH:
-glycine",,56-40-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14889/7/4/2/?documentUUID=1e4cdeac-7f62-4aac-850f-4aa7ff6459c8,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(C(=O)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/750,PubChem,NCC(=O)O,Train,1,2702,training
-"EU_REACH:
-2-propenoic acid, 2-methyl-, 4-benzoylphenyl ester",,56467-43-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22095/7/4/2/?documentUUID=5ccc383c-7a8c-4d31-b272-cc012aafba0d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OC1=CC=C(C=C1)C(=O)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/11230895,PubChem,C=C(C)C(=O)Oc1ccc(C(=O)c2ccccc2)cc1,Train,1,2702,training
-"NZ_CCID:
-4-(Dimethylamino) azobenzene -4'-sulphonyl chloride",,56512-49-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BBF5E72A-AB3B-45B5-8EEF-420BD5DE88DF,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CN(C)C1=CC=C(C=C1)N=NC2=CC=C(C=C2)S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/91660,PubChem,CN(C)c1ccc(N=Nc2ccc(S(=O)(=O)Cl)cc2)cc1,Train,1,2702,training
-"NZ_CCID:
-2,3-Dimethylpentane",,565-59-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/20FF6462-2D93-46CD-B4DE-79A14302897E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CCC(C)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11260,PubChem,CCC(C)C(C)C,Train,1,2702,training
-"NZ_CCID:
-2,3,4-Trimethylpentane",,565-75-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/092521F8-56E1-472D-A657-3088291D5A5B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]",,NZ_CCID,1,CC(C)C(C)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11269,PubChem,CC(C)C(C)C(C)C,Train,1,2702,training
-"EU_REACH:
-[2-methyl-2-(2-methylpropyl)-1,3-dioxolan-4-yl]methanol",,5660-53-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/9997/7/4/2/?documentUUID=d641f04b-2087-4e8a-a386-a4d9bf2b09cd,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CC1(OCC(O1)CO)C,https://pubchem.ncbi.nlm.nih.gov/compound/21869,PubChem,CC(C)CC1(C)OCC(CO)O1,Train,1,2702,training
-"NZ_CCID:
-4-Chloro-5-isopropyl-2-methylphenol",,5665-94-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A70F7F80-80B9-4341-95A2-38995081191D,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=CC(=C(C=C1O)C(C)C)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/21874,PubChem,Cc1cc(Cl)c(C(C)C)cc1O,Train,1,2702,training
-"EU_REACH:
-4,4,13,13-tetraethoxy-3,14-dioxa-8,9-dithia-4,13-disilahexadecane",,56706-10-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14258/7/4/2/?documentUUID=eccda6cb-6f1d-45a4-8ae1-6da16abb08dc,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](CCCSSCCC[Si](OCC)(OCC)OCC)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/92506,PubChem,CCO[Si](CCCSSCCC[Si](OCC)(OCC)OCC)(OCC)OCC,Train,1,2702,training
-"NZ_CCID:
-2-(Dimethylamino)pyridine","NZ_CCID:
-2-dimethylaminopyridine",5683-33-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CC1C892D-E33E-4AF9-8E89-649C1B0DEA08,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CN(C)C1=CC=CC=N1,https://pubchem.ncbi.nlm.nih.gov/compound/21885,PubChem,CN(C)c1ccccn1,Train,1,2702,training
-"EU_REACH:
-aspartic acid",,56-84-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14876/7/4/2/?documentUUID=cab159ce-6486-43dd-b19b-6e083a2fa76d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C([C@@H](C(=O)O)N)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/5960,PubChem,N[C@@H](CC(=O)O)C(=O)O,Train,1,2702,training
-"US_HSDB:
-GLUTAMIC ACID",,56-86-0,Cat 1,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/490,,,US_HSDB,1,C(CC(=O)O)[C@@H](C(=O)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/33032,PubChem,N[C@@H](CCC(=O)O)C(=O)O,Train,1,2702,training
-"NZ_CCID:
-Linoleic diethanolamide","NZ_CCID:
-9,12-Octadecadienamide, N,N-bis(2-hydroxyethyl)-, (9Z,12Z)-, Linoleamide DEA, Linoleic acid diethanolamide, N,N-Bis(2-hydroxyethyl)-9,12-octadecadienamide",56863-02-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F23AE3CD-36C0-49C1-BE35-8FF600DCEFC2,"NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Severe irritant
-REFERENCE SOURCE: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 5(5),415,1986 [http://hazard.com/msds/tox/tf/q87/q634.html]
-Eye Irritation
-R PHRASE: R 41 [Danish EPA]",,NZ_CCID,1,CCCCC/C=C\C/C=C\CCCCCCCC(=O)N(CCO)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/9976267,PubChem,CCCCC/C=C\C/C=C\CCCCCCCC(=O)N(CCO)CCO,Train,1,2702,training
-"EU_REACH:
-cystine",,56-89-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5911/7/4/2/?documentUUID=6a3365f1-45be-43bb-ae63-b9fc3a3bdb4d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C([C@@H](C(=O)O)N)SSC[C@@H](C(=O)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/67678,PubChem,N[C@@H](CSSC[C@H](N)C(=O)O)C(=O)O,Train,1,2702,training
-"EU_REACH:
-3-bromo-5-chlorophenol",,56962-04-0,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1147/7/4/2/?documentUUID=42db6bdc-e3ec-4487-a652-0ecae33db95f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(C=C(C=C1Cl)Br)O,https://pubchem.ncbi.nlm.nih.gov/compound/22630180,PubChem,Oc1cc(Cl)cc(Br)c1,Train,1,2702,training
-"EU_REACH:
-1-(5,5-dimethylcyclohex-1-en-1-yl)pent-4-en-1-one",,56973-85-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19874/7/4/2/?documentUUID=71b6ca85-203f-43f1-b6b1-3898923bf2a0,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(CCC=C(C1)C(=O)CCC=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/92606,PubChem,C=CCCC(=O)C1=CCCC(C)(C)C1,Train,1,2702,training
-"EU_REACH:
-2-methyl-N-(4-sulfamoylphenyl) prop-2-enamide",,56992-87-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12879/7/4/2/?documentUUID=1214008c-6c66-4893-b633-b767eef300a3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)NC1=CC=C(C=C1)S(=O)(=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/350062,PubChem,C=C(C)C(=O)Nc1ccc(S(N)(=O)=O)cc1,Train,1,2702,training
-"EU_REACH:
-N-carbamimidoyl-N-methylglycine",,57-00-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12796/7/4/2/?documentUUID=a1bcc0d9-7cab-45ae-93c6-5fc97e7304aa,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(CC(=O)O)C(=N)N,https://pubchem.ncbi.nlm.nih.gov/compound/586,PubChem,CN(CC(=O)O)C(=N)N,Train,1,2702,training
-"JP_CHRIP:
-O-(2,6-dichloro-p-tolyl) O,O-dimethyl thiophosphate; Tolclofos-methyl",,57018-04-9,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0076e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified as ""Not classified"" from (1) - (3).
-
-[Evidence Data]
-(1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, occlusive, 4-hour application, 72-hour observation), all the animals showed erythema and edema after 1 hour, but all effects were fully reversible within 72 hours (erythema/eschar score: 0.7/0.3/0.7, edema score: 0.3/0/0.3) (ECHA RAC Opinion (2019), CLH Report (2018)).
-(2) It is reported that in a skin irritation test with rabbits (n = 6) (occlusive, 4-hour application, 7-day observation), no skin irritation reactions were seen in any animal (erythema/eschar score: 0/0/0/0/0/0, edema score: 0/0/0/0/0/0) (ECHA RAC Opinion (2019), CLH Report (2018), JMPR (1994)).
-(3) It is reported that in a skin irritation test with rabbits (n = 6) (semi-occlusive, 4-hour application, 72-hour observation), no skin irritation reactions were found in any animal (erythema/eschar score: 0/0/0/0/0/0, edema score: 0/0/0/0/0/0) (ECHA RAC Opinion (2019), CLH Report (2018)).",Provided,JP_CHRIP,1,COP(=S)(OC)Oc1c(Cl)cc(C)cc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.904F,J-GLOBAL,COP(=S)(OC)Oc1c(Cl)cc(C)cc1Cl,Train,1,2702,training
-"JP_CHRIP:
-Allyl isothiocyanate
-
-NZ_CCID:
-Allyl isothiocyanate","JP_CHRIP:
-2-Propenyl isothiocyanate
-3-Isothiocyanato-1-propene
-Allyl isosulfocyanate",57-06-7,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-2057e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6562E85F-DF85-4E89-A380-A7CBFF4461E2","JP_CHRIP:
-It was classified in Category 2 because it is described that in humans, this substance irritates the mucous membranes and induces eczematous or vesicular skin reactions, and the substance strongly irritates the skin and mucous membranes (IARC 73 (1999)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,"JP_CHRIP, NZ_CCID",2,C=CCN=C=S,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.165G,J-GLOBAL,C=CCN=C=S,Train,1,2702,training
-"EU_REACH:
-urea",,57-13-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16152/7/4/2/?documentUUID=46811fa1-5ff6-40b1-ad46-5b837aee2aa9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(=O)(N)N,https://pubchem.ncbi.nlm.nih.gov/compound/1176,PubChem,NC(N)=O,Train,1,2702,training
-"NZ_CCID:
-1-Bromo-2-naphthol",,573-97-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8CE338FB-CDE8-4416-B13E-9185EDA66CD3,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C1=CC=C2C(=C1)C=CC(=C2Br)O,https://pubchem.ncbi.nlm.nih.gov/compound/11316,PubChem,Oc1ccc2ccccc2c1Br,Train,1,2702,training
-"NZ_CCID:
-1,2-Dihydroxynaphthalene",,574-00-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/598E0289-A4DF-4501-B6C2-BB8E540C9767,,,NZ_CCID,1,C1=CC=C2C(=C1)C=CC(=C2O)O,https://pubchem.ncbi.nlm.nih.gov/compound/11318,PubChem,Oc1ccc2ccccc2c1O,Train,1,2702,training
-"JP_CHRIP:
-Propane-1,2-diol (Propylene glycol)","JP_CHRIP:
-1,2-Dihydroxypropane
-1,2-Propanediol
-Methyl ethylene glycol
-Propylene glycol",57-55-6,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-meti-0003e.html,"JP_CHRIP:
-[Rationale for the Classification]
-Based on (1)-(5), it was classified as ""Not classified.""
-
-[Evidence Data]
-(1) There is a report that no irritation was observed when the undiluted liquid of this substance was applied to human skin for 48 hours (SIDS (2004)).
-(2) There is a report that no irritation was observed when the undiluted liquid of this substance was applied to the skin of six people for 2 hours (SIDS (2004)).
-(3) There is a report that no irritation was observed in a skin irritation test (OECD TG404) with rabbits (SIDS (2004)).
-(4) There is a report that no irritation was observed in a skin irritation test (the modified Draize method) with rabbits (SIDS (2004)).
-(5) There is a report that this substance is non irritant in a skin irritation test (EPA OPPTS 870.2400) with rabbits (EPA Pesticide RED (2006)).",Provided,JP_CHRIP,1,CC(O)CO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.918F,J-GLOBAL,CC(O)CO,Train,1,2702,training
-"AU_HCIS:
-beta-panolide
-
-JP_CHRIP:
-propiolactone
-
-NZ_CCID:
-Propiolactone","AU_HCIS:
-1,3-propiolactone
-2-Oxetanone
-3-hydroxypropionic acid lactone
-3-propanolide
-hydracrylic acid beta-lactone
-
-JP_CHRIP:
-.beta.-Propiolactone
-1,3-Propiolactone
-2-Oxetanone
-beta-Propiolactone
-beta-Propionolactone
-hydracrylolactone (synonym:beta-propiolactone)
-Propanolide
-
-NZ_CCID:
-1,3-Propiolactone, 2-Oxetanone, 3-Hydroxypropionic acid lactone, 3-Propanolide, 3-Propiolactone, Betaprone, Propanolide",57-57-8,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3355
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0934e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2F550D76-70E1-4C8E-9BEB-605E31A23251","JP_CHRIP:
-From description that skin burns (blistering of the skin, hair loss, and scarring) was seen in humans evidence of exposure (HSDB (Access on May 2005)), and description that the skin was stimulated (ICSC (J), (1997), and SITTIG (4th, 2002)), and irritation (erythema-scarring) was accepted with mouse (ACGIH (7th, 2001)), it was set as Category 2.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]
-Eye Irritation
-R PHRASE: R 36 [ECB]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,O=C1CCO1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.327B,J-GLOBAL,O=C1CCO1,Train,1,2702,training
-"NZ_CCID:
-2,3-Dichlorophenol",,576-24-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0154F56E-46AE-41EC-8F82-386D6371BDA1,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C(=C1)Cl)Cl)O,https://pubchem.ncbi.nlm.nih.gov/compound/11334,PubChem,Oc1cccc(Cl)c1Cl,Train,1,2702,training
-"JP_CHRIP:
-2,6-Xylenol
-
-KR_NCIS:
-2,6-Xylenol
-
-NZ_CCID:
-2,6-Dimethylphenol","JP_CHRIP:
-2,6-Xylenol
-Phenol, 2,6-dimethyl-
-
-KR_NCIS:
-1-Hydroxy-2,6-dimethylbenzene; 2,6-Dimethylphenol; Phenol, 2,6-dimethyl-
-
-NZ_CCID:
-2,6-xylenol",576-26-1,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-meti-0026e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/82CFF4F4-A7AD-4E56-B85A-63A8D59D8301","JP_CHRIP:
-There are descriptions that this substance is corrosive to the skin (Environmental Risk Assessment for Chemical Substances Vol.5 (Ministry of the Environment, 2006)) and may cause chemical burns (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). There are also descriptions that topical application of this substance on the skin of rats, rabbits, and guinea pigs causes irritation and produces ulcers in the application site (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). In addition, there is a description that this substance is corrosive when applied to rabbit skin (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). From the above, this substance was classified in Category 1. In addition, this substance was classified as ""Skin. Corr. 1B H314"" in the EU CLP classification (ECHA CL Inventory (Access, October 2015)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,Cc1cccc(C)c1O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J43.458B,J-GLOBAL,Cc1cccc(C)c1O,Train,1,2702,training
-"NZ_CCID:
-Sulphaguanidine",,57-67-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7D9985C9-8E9F-4D40-9036-1758CFA24D8F,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [MSDS] [Sigma-Aldrich]
-Eye Irritation
-R PHRASE: R 36 [MSDS] [Sigma-Aldrich]",,NZ_CCID,1,C1=CC(=CC=C1N)S(=O)(=O)N=C(N)N,https://pubchem.ncbi.nlm.nih.gov/compound/5324,PubChem,NC(N)=NS(=O)(=O)c1ccc(N)cc1,Train,1,2702,training
-"NZ_CCID:
-Chloroglyoxylic acid methyl ester","NZ_CCID:
-methyl oxalyl chloride",5781-53-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/900C6E31-0BEE-4332-9FA4-BCDEE52D4DBC,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,COC(=O)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/79846,PubChem,COC(=O)C(=O)Cl,Train,1,2702,training
-"EU_REACH:
-N,N,N',N'-tetrakis(2-hydroxypropyl)hexanediamide",,57843-53-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10149/7/4/2/?documentUUID=567d1f2d-bfb7-4266-b931-059762b9bbb8,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CN(CC(C)O)C(=O)CCCCC(=O)N(CC(C)O)CC(C)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/93821,PubChem,CC(O)CN(CC(C)O)C(=O)CCCCC(=O)N(CC(C)O)CC(C)O,Test,1,2702,training
-"NZ_CCID:
-8-Aminoquinoline",,578-66-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/86C0BBFA-F620-4984-85BA-9AC421A64544,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC2=C(C(=C1)N)N=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/11359,PubChem,Nc1cccc2cccnc12,Train,1,2702,training
-"NZ_CCID:
-4,4'-Difluorobenzil",,579-39-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/282185ED-F199-45A3-9B96-A6B2865B7E10,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1C(=O)C(=O)C2=CC=C(C=C2)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/123072,PubChem,O=C(C(=O)c1ccc(F)cc1)c1ccc(F)cc1,Train,1,2702,training
-"AU_HCIS:
-Phenol, 2,4-bis(1,1,3,3-tetramethylbutyl)-",,5806-72-4,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5805,,,AU_HCIS,1,CC(C)(C)CC(C)(C)C1=CC(=C(C=C1)O)C(C)(C)CC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/79870,PubChem,CC(C)(C)CC(C)(C)c1ccc(O)c(C(C)(C)CC(C)(C)C)c1,Train,1,2702,training
-"EU_REACH:
-2-chloro-N,N-dimethyl-3-oxobutanamide",,5810-11-7,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6415/7/4/2/?documentUUID=c8ad8511-eb82-4406-ba50-722ef2173561,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)N(C)C)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/93011,PubChem,CC(=O)C(Cl)C(=O)N(C)C,Test,1,2702,training
-"JP_CHRIP:
-Bis(2-ethylhexyl) dithiophosphate",,5810-88-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0205e.html,"JP_CHRIP:
-The substance was classified as Category 1 based on the documented case that 24-hour open-application of 0.01 mL of undiluted substance to rabbit caused necrosis, and irritation index was grade 7 by grading according to 10 ranks (maximum grade was 10) (RTECS (1997), American Industrial Hygiene Association Journal vol. 23, p.95 (1962)) by confirming the original literature.",,JP_CHRIP,1,CCCCC(CC)COP(=S)(S)OCC(CC)CCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J50.421A,J-GLOBAL,CCCCC(CC)COP(=S)(S)OCC(CC)CCCC,Train,1,2702,training
-"EU_REACH:
-(4E,9E)-7-ethenyl-4,10-dimethyl-7-{[(E)-(pentan-2-ylidene)amino]oxy}-6,8-dioxa-5,9-diaza-7-silatrideca-4,9-diene; (4Z,9E)-7-ethenyl-4,10-dimethyl-7-{[(E)-(pentan-2-ylidene)amino]oxy}-6,8-dioxa-5,9-diaza-7-silatrideca-4,9-diene; (4Z,9Z)-7-ethenyl-4,10-dimethyl-7-{[(E)-(pentan-2-ylidene)amino]oxy}-6,8-dioxa-5,9-diaza-7-silatrideca-4,9-diene; (4Z,9Z)-7-ethenyl-4,10-dimethyl-7-{[(Z)-(pentan-2-ylidene)amino]oxy}-6,8-dioxa-5,9-diaza-7-silatrideca-4,9-diene",,58190-62-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11181/7/4/2/?documentUUID=8bff6b81-e83e-4fef-8655-2920d1013736,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC/C(=N/O[Si](O/N=C(/CCC)\C)(O/N=C(/CCC)\C)C=C)/C,https://pubchem.ncbi.nlm.nih.gov/compound/154734417,PubChem,C=C[Si](O/N=C(\C)CCC)(O/N=C(\C)CCC)O/N=C(\C)CCC,Train,1,2702,training
-"NZ_CCID:
-2,7-Naphthalene diol","NZ_CCID:
-2,7-dihydroxynaphthalene",582-17-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6694C227-CE2A-44AD-9A8F-7947F4696AA6,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC2=C1C=CC(=C2)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/11397,PubChem,Oc1ccc2ccc(O)cc2c1,Train,1,2702,training
-"NZ_CCID:
-N,N-Dimethylhexanamide","NZ_CCID:
-Hexanamide, N,N-dimethyl-",5830-30-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9D5BAA02-36C1-4B4E-8A53-6A8447C2D46B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCC(=O)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/22084,PubChem,CCCCCC(=O)N(C)C,Train,1,2702,training
-"NZ_CCID:
-2-Hydroxycinnamic acid",,583-17-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1445B1AD-F6F9-4FEC-951D-8C13694DB6A4,,,NZ_CCID,1,C1=CC=C(C(=C1)/C=C/C(=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/637540,PubChem,O=C(O)/C=C/c1ccccc1O,Train,1,2702,training
-"EU_REACH:
-N,N-Dibutyloleamide",,5831-80-1,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5664/7/4/2/?documentUUID=753336da-0c38-444b-ae2f-76866541c679,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCC/C=C\CCCCCCCC(=O)N(CCCC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/6436342,PubChem,CCCCCCCC/C=C\CCCCCCCC(=O)N(CCCC)CCCC,Test,1,2702,training
-"NZ_CCID:
-3,4-Dimethylhexane","NZ_CCID:
-Hexane, 3,4-dimethyl-",583-48-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4242E0DF-35A4-4B1F-86E7-E882AD4AAF5A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]",,NZ_CCID,1,CCC(C)C(C)CC,https://pubchem.ncbi.nlm.nih.gov/compound/11412,PubChem,CCC(C)C(C)CC,Train,1,2702,training
-"NZ_CCID:
-1,2-Dibromobenzene","NZ_CCID:
-o-dibromobenzene",583-53-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2E03F58C-E80B-4F78-B618-EC7082D4BBBE,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)Br)Br,https://pubchem.ncbi.nlm.nih.gov/compound/11414,PubChem,Brc1ccccc1Br,Train,1,2702,training
-"NZ_CCID:
-2,5-Dichlorophenol",,583-78-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/00A9DE3B-1317-4284-83A4-49D59DA1882E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C=C1Cl)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/66,PubChem,Oc1cc(Cl)ccc1Cl,Train,1,2702,training
-"JP_CHRIP:
-Butyric acid, 2-hydroxy-4-(methylthio)-",,583-91-5,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-1324e.html,"JP_CHRIP:
-It was set to category 2 from the description that mild irritation (slight;4 hr) is indicated in the rabbit skin or a middle degree stimulus (Moderate; 24 hr) is indicated in vitro test (IUCLID, 2000).",,JP_CHRIP,1,CSCCC(O)C(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J21.888J,J-GLOBAL,CSCCC(O)C(=O)O,Train,1,2702,training
-"NZ_CCID:
-Silane, chloro(1,1-dimethylethyl)diphenyl-","NZ_CCID:
-tert-Butyl-diphenylchlorosilane",58479-61-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/341BCC26-5DCA-49AC-BA20-8C02238CCE5A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)(C)[Si](C1=CC=CC=C1)(C2=CC=CC=C2)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/94078,PubChem,CC(C)(C)[Si](Cl)(c1ccccc1)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-2,3-Dimethylhexane",,584-94-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FEA224B6-7DEF-482A-B6E3-7C1CC2061B0C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]",,NZ_CCID,1,CCCC(C)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11447,PubChem,CCCC(C)C(C)C,Train,1,2702,training
-"EU_REACH:
-tert-butyl 2-methylprop-2-enoate",,585-07-9,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2073/7/4/2/?documentUUID=62e529c2-51b7-433f-8c96-420d77303794,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11448,PubChem,C=C(C)C(=O)OC(C)(C)C,Train,1,2702,training
-"NZ_CCID:
-4-Bromobenzoyl chloride",,586-75-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/690080AE-0D52-49FF-8415-55C3BCC1C71B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1C(=O)Cl)Br,https://pubchem.ncbi.nlm.nih.gov/compound/68515,PubChem,O=C(Cl)c1ccc(Br)cc1,Train,1,2702,training
-"NZ_CCID:
-4-Pyridylmethanol","NZ_CCID:
-4-pyridylcarbinol",586-95-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1F4909E5-164F-4B7A-829B-C235E82864EB,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CN=CC=C1CO,https://pubchem.ncbi.nlm.nih.gov/compound/11472,PubChem,OCc1ccncc1,Train,1,2702,training
-"NZ_CCID:
-2-Pyridylmethanol","NZ_CCID:
-2-pyridylcarbinol",586-98-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DFAE45C8-2565-4F0E-B965-AA9B6DBA7BC1,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=NC(=C1)CO,https://pubchem.ncbi.nlm.nih.gov/compound/11474,PubChem,OCc1ccccn1,Train,1,2702,training
-"NZ_CCID:
-3-Chlorobenzaldehyde",,587-04-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F1C78CE9-5CF0-47AC-83A5-597BDBDF2B53,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)Cl)C=O,https://pubchem.ncbi.nlm.nih.gov/compound/11477,PubChem,O=Cc1cccc(Cl)c1,Train,1,2702,training
-"NZ_CCID:
-Butane, 1,1,3-triethoxy-",,5870-82-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D93F0599-60C3-49B9-AA90-439E16DF1B13,,,NZ_CCID,1,CCOC(C)CC(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/22163,PubChem,CCOC(C)CC(OCC)OCC,Train,1,2702,training
-"AU_HCIS:
-Benzene, 1-isocyanato-2-[(4-isocyanatophenyl)methyl]-
-
-KR_NCIS:
-1-Isocyanato-2-[(4-isocyanatophenyl)methyl]benzene","AU_HCIS:
-o-(pisocyanatobenzyl) phenyl isocyanate
-diphenylmethane-2,4'- diisocyanate",5873-54-1,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=368
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,"AU_HCIS, KR_NCIS",2,C1=CC=C(C(=C1)CC2=CC=C(C=C2)N=C=O)N=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/62593,PubChem,O=C=Nc1ccc(Cc2ccccc2N=C=O)cc1,Train,1,2702,training
-"EU_REACH:
-3-cyclohexyl-1-[4-({4-[(cyclohexylcarbamoyl)amino]phenyl}methyl)phenyl]urea; 3-cyclohexyl-1-[4-({4-[(phenylcarbamoyl)amino]phenyl}methyl)phenyl]urea; 3-phenyl-1-[4-({4-[(phenylcarbamoyl)amino]phenyl}methyl)phenyl]urea",,58890-25-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/9641/7/4/2/?documentUUID=3bea48a6-e3ce-455d-9644-9e4d6f2e0acf,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CCC(CC1)NC(=O)NC2=CC=C(C=C2)CC3=CC=C(C=C3)NC(=O)NC4CCCCC4,https://pubchem.ncbi.nlm.nih.gov/compound/352756,PubChem,O=C(Nc1ccc(Cc2ccc(NC(=O)NC3CCCCC3)cc2)cc1)NC1CCCCC1,Train,1,2702,training
-"EU_CLP:
-2,3,4,6-tetrachlorophenol",,58-90-2,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=C(C(=C(C(=C1Cl)Cl)Cl)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/6028,PubChem,Oc1c(Cl)cc(Cl)c(Cl)c1Cl,Test,1,2702,training
-"NZ_CCID:
-4-Bromobenzyl bromide",,589-15-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B79CB1B1-3B2C-46C3-A7BB-D69820AE3F6D,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1CBr)Br,https://pubchem.ncbi.nlm.nih.gov/compound/68527,PubChem,BrCc1ccc(Br)cc1,Train,1,2702,training
-"NZ_CCID:
-3-Methylhexane",,589-34-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D533150A-E4E4-4FCA-961B-5915BC6CC641,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CCCC(C)CC,https://pubchem.ncbi.nlm.nih.gov/compound/11507,PubChem,CCCC(C)CC,Train,1,2702,training
-"NZ_CCID:
-2,4-Dimethylhexane",,589-43-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C4485639-8B90-47D4-9025-5D12B572EFF4,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]",,NZ_CCID,1,CCC(C)CC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11511,PubChem,CCC(C)CC(C)C,Train,1,2702,training
-"NZ_CCID:
-4-Methylheptane",,589-53-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/032B18F6-DEFD-481F-AF52-680FA3A2D239,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]",,NZ_CCID,1,CCCC(C)CCC,https://pubchem.ncbi.nlm.nih.gov/compound/11512,PubChem,CCCC(C)CCC,Train,1,2702,training
-"NZ_CCID:
-3-Methylheptane",,589-81-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DF4BC51F-7FAC-40BC-9AD3-CF9CB4D5D2BF,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CCCCC(C)CC,https://pubchem.ncbi.nlm.nih.gov/compound/11519,PubChem,CCCCC(C)CC,Train,1,2702,training
-"EU_CLP:
-1,4-dimethylcyclohexane",,589-90-2,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC1CCC(CC1)C,https://pubchem.ncbi.nlm.nih.gov/compound/11523,PubChem,CC1CCC(C)CC1,Test,1,2702,training
-"ChemSkin:
-n-Butyl propionate",,590-01-2,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,CCCCOC(=O)CC,https://pubchem.ncbi.nlm.nih.gov/compound/11529,PubChem,CCCCOC(=O)CC,Test,1,2702,training
-"NZ_CCID:
-Bromoacetonitrile",,590-17-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A23415D2-3C91-44B1-A36E-865420FDECE5,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C(C#N)Br,https://pubchem.ncbi.nlm.nih.gov/compound/11534,PubChem,N#CCBr,Train,1,2702,training
-"NZ_CCID:
-2,2-Dimethylpentane","NZ_CCID:
-Pentane, 2,2-dimethyl-",590-35-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D383B7CF-A602-46A7-9FE6-F4070BAEFB0B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]",,NZ_CCID,1,CCCC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11542,PubChem,CCCC(C)(C)C,Train,1,2702,training
-"NZ_CCID:
-2,2-Dimethylhexane",,590-73-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BADABCA0-61B9-4F9B-B451-CE9268D5C63B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]",,NZ_CCID,1,CCCCC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11551,PubChem,CCCCC(C)(C)C,Train,1,2702,training
-"JP_CHRIP:
-3-Methylbutanal
-
-NZ_CCID:
-3-Methylbutyraldehyde","JP_CHRIP:
-3-Methylbutyraldehyde
-Isopentaldehyde
-Isopentanal
-Isovaleraldehyde",590-86-3,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0020e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C18FDC0F-6E93-4CBA-AD7F-9E28523A5AB1","JP_CHRIP:
-Based on results of skin primary irritation index (PII: 2.83) after application for 4-hour in a rabbit test (OECD TG404) (SIDS (2000)) and ""strong irritating ""after application for 24-hour in another rabbit test (SIDS (2000)), the substance was classified into Category 2.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",Provided,"JP_CHRIP, NZ_CCID",2,CC(C)CC=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J6.754G,J-GLOBAL,CC(C)CC=O,Train,1,2702,training
-"NZ_CCID:
-Cyclopropyl methyl chloride",,5911-08-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7EBC1A4C-BB0F-4507-AAC9-6244A376CE9B,,,NZ_CCID,1,C1CC1CCl,https://pubchem.ncbi.nlm.nih.gov/compound/80013,PubChem,ClCC1CC1,Train,1,2702,training
-"NZ_CCID:
-3-Bromotoluene",,591-17-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D3BCAC3B-2C52-45B7-BFB8-C884B513A06A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=CC(=CC=C1)Br,https://pubchem.ncbi.nlm.nih.gov/compound/11560,PubChem,Cc1cccc(Br)c1,Train,1,2702,training
-"NZ_CCID:
-3-Bromophenol",,591-20-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CBAA1167-74F0-4A17-99FF-97D80AD5EB56,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)Br)O,https://pubchem.ncbi.nlm.nih.gov/compound/11563,PubChem,Oc1cccc(Br)c1,Train,1,2702,training
-"EU_REACH:
-1,4,6,10-Dodecatetraen-3-ol,3,7,11-trimethyl-,(4E,6E)-",,59121-99-2,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22683/7/4/2/?documentUUID=6ecbc22f-fed7-41ae-9d53-1832a75af566,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=CCC/C(=C/C=C/[C@@](C)(C=C)O)/C)C,https://pubchem.ncbi.nlm.nih.gov/compound/154734787,PubChem,C=C[C@@](C)(O)/C=C/C=C(\C)CCC=C(C)C,Test,1,2702,training
-"NZ_CCID:
-3,5-Dimethylpyridine","NZ_CCID:
-3,5-lutidine",591-22-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2D293F8F-331A-49EB-AB38-AB794D4CD43B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=CC(=CN=C1)C,https://pubchem.ncbi.nlm.nih.gov/compound/11565,PubChem,Cc1cncc(C)c1,Train,1,2702,training
-"EU_REACH:
-hexadecyl 2-ethylhexanoate",,59130-69-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11691/7/4/2/?documentUUID=8a74c534-e4f2-4471-8cf1-5ff5a65d4738,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/42956,PubChem,CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC,Train,1,2702,training
-"NZ_CCID:
-2-Methylhexane","NZ_CCID:
-Hexane, 2-methyl-",591-76-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8209E49D-7D40-4FB5-8114-E4412A2EB5F8,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]",,NZ_CCID,1,CCCCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11582,PubChem,CCCCC(C)C,Train,1,2702,training
-"NZ_CCID:
-4-Pentenoic acid",,591-80-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5E13A0D1-D98C-4867-97C0-64205419FB68,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C=CCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/61138,PubChem,C=CCCC(=O)O,Train,1,2702,training
-"NZ_CCID:
-2,5-Dimethylhexane",,592-13-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6AB48271-7624-4FA9-BE2F-ABE9DAD8B6A2,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]",,NZ_CCID,1,CC(C)CCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11592,PubChem,CC(C)CCC(C)C,Train,1,2702,training
-"EU_REACH:
-6-nonyl-1,3,5-triazine-2,4-diamine",,5921-65-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24536/7/4/2/?documentUUID=3eef8de1-f5ec-4e35-a941-5d70d474f8e5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCC1=NC(=NC(=N1)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/22209,PubChem,CCCCCCCCCc1nc(N)nc(N)n1,Train,1,2702,training
-"NZ_CCID:
-2-Methylheptane",,592-27-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/41AB5F9F-8581-4430-8DB3-EACD2D0C3DD0,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]",,NZ_CCID,1,CCCCCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11594,PubChem,CCCCCC(C)C,Train,1,2702,training
-"EU_CLP:
-1-octylazepin-2-one",,59227-88-2,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCCCCCCCN1CCCCCC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/2754067,PubChem,CCCCCCCCN1CCCCCC1=O,Test,1,2702,training
-"NZ_CCID:
-Butylchloroformate","NZ_CCID:
-butyl chloroformate",592-34-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D4496ED3-07D3-46B1-A4A1-F38C101D5260,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCOC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/61140,PubChem,CCCCOC(=O)Cl,Train,1,2702,training
-"ChemSkin:
-1,5-Hexadiene",,592-42-7,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,C=CCCC=C,https://pubchem.ncbi.nlm.nih.gov/compound/11598,PubChem,C=CCCC=C,Test,1,2702,training
-"NZ_CCID:
-2(1H)-Quinolinone",,59-31-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/17801E53-B11F-47CD-AD2B-4F0ED1F7CBDA,,,NZ_CCID,1,C1=CC=C2C(=C1)C=CC(=O)N2,https://pubchem.ncbi.nlm.nih.gov/compound/6038,PubChem,O=c1ccc2ccccc2[nH]1,Train,1,2702,training
-"NZ_CCID:
-Petroselinic acid",,593-39-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/79F1DECB-DA36-400E-8F76-DDB0EC724D46,,,NZ_CCID,1,CCCCCCCCCCC/C=C\CCCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/5281125,PubChem,CCCCCCCCCCC/C=C\CCCCC(=O)O,Train,1,2702,training
-"NZ_CCID:
-Chloroiodomethane",,593-71-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9A384553-70B5-445A-A7E5-7E019E434EE6,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(Cl)I,https://pubchem.ncbi.nlm.nih.gov/compound/11644,PubChem,ClCI,Train,1,2702,training
-"NZ_CCID:
-2-Chloro-2-methylbutane",,594-36-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D2DD5A95-C8AB-4D63-8ED2-6A5C62C591D1,"NZ_CCID:
-Skin Irritation
-REMARK: SKIN The liquid may produce skin discomfort following prolonged contact. Defatting and/or drying of the skin may lead to dermatitis. The material may accentuate any pre-existing skin condition.
-REFERENCE SOURCE: [Chemwatch]
-Eye Irritation
-REMARK: EYE: The liquid is discomforting to the eyes and is capable of causing a mild, temporary redness of the conjunctiva (similar to wind-burn), temporary impairment of vision and/ or other transient eye damage/ ulceration.
-REFERENCE SOURCE: [Chemwatch]",,NZ_CCID,1,CCC(C)(C)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/61143,PubChem,CCC(C)(C)Cl,Train,1,2702,training
-"JP_CHRIP:
-Trichloromethylsulfenyl chloride","JP_CHRIP:
-Perchloromethyl mercaptan
-Thiocarbonyl tetrachloride
-Trichlormethyl sulfur chloride
-Trichloromethanesulfenyl chloride
-Trichloromethyl sulfochloride
-Trichloromethylsulfenyl chloride",594-42-3,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2072e.html,"JP_CHRIP:
-Based on descriptions that in a skin irritation test with guinea pigs, severe irritation was observed (PATTY (6th, 2012)), and that it shows severe irritation to the rabbit skin (PATTY (6th, 2012)), it was classified in Category 2.",,JP_CHRIP,1,ClSC(Cl)(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J6.775J,J-GLOBAL,ClSC(Cl)(Cl)Cl,Train,1,2702,training
-"NZ_CCID:
-Ethanesulphonyl chloride",,594-44-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0DD79180-B65D-403B-A373-5C6C727C3B1F,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCS(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11667,PubChem,CCS(=O)(=O)Cl,Train,1,2702,training
-"NZ_CCID:
-Ethanesulphonic acid",,594-45-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0E7599B6-2B93-49D6-88E9-E84052D903CE,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCS(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/11668,PubChem,CCS(=O)(=O)O,Train,1,2702,training
-"EU_REACH:
-4-(2-{4-[(diphenoxyphosphoryl)oxy]phenyl}propan-2-yl)phenyl diphenyl phosphate; 4-{2-[4-({[4-(2-{4-[(diphenoxyphosphoryl)oxy]phenyl}propan-2-yl)phenoxy](phenoxy)phosphoryl}oxy)phenyl]propan-2-yl}phenyl diphenyl phosphate",,5945-33-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5460/7/4/2/?documentUUID=3d700bf9-86c0-414a-809b-8c7f087f41d5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C1=CC=C(C=C1)OP(=O)(OC2=CC=CC=C2)OC3=CC=CC=C3)C4=CC=C(C=C4)OP(=O)(OC5=CC=CC=C5)OC6=CC=CC=C6,https://pubchem.ncbi.nlm.nih.gov/compound/9874825,PubChem,CC(C)(c1ccc(OP(=O)(Oc2ccccc2)Oc2ccccc2)cc1)c1ccc(OP(=O)(Oc2ccccc2)Oc2ccccc2)cc1,Train,1,2702,training
-"NZ_CCID:
-2-Hydroxyisobutyric acid",,594-61-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E334708D-5CFF-4C3A-BFB8-D8F24BD70DD2,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(C)(C(=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/11671,PubChem,CC(C)(O)C(=O)O,Train,1,2702,training
-"JP_CHRIP:
-1,1-dichloro-1-nitroethane","JP_CHRIP:
-Ethane,1,1-dichloro-1-nitro-",594-72-9,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0768e.html,"JP_CHRIP:
-It was classified as Category 2 as it showed irritation in rabbit skin test (ACGIH (2001)).",,JP_CHRIP,1,CC(Cl)(Cl)[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J6.776H,J-GLOBAL,CC(Cl)(Cl)[N+](=O)[O-],Train,1,2702,training
-"EU_REACH:
-4-({5-[(4-carbamoylphenyl)carbamoyl]-2-methoxyphenyl}diazenyl)-N-(5-chloro-2,4-dimethoxyphenyl)-3-hydroxy-2-naphthamide",,59487-23-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11266/7/4/2/?documentUUID=788de4ff-551e-46e8-a237-24a5df01d85d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=C(C=C(C=C1)C(=O)NC2=CC=C(C=C2)C(=O)N)N=NC3=C(C(=CC4=CC=CC=C43)C(=O)NC5=CC(=C(C=C5OC)OC)Cl)O,https://pubchem.ncbi.nlm.nih.gov/compound/62154,PubChem,COc1cc(OC)c(NC(=O)c2cc3ccccc3c(N=Nc3cc(C(=O)Nc4ccc(C(N)=O)cc4)ccc3OC)c2O)cc1Cl,Train,1,2702,training
-"AU_HCIS:
-chlorocresol","AU_HCIS:
-4- chloro-m-cresol
-4- chloro-3-methylphenol
-Phenol, 4-chloro-3-methyl-",59-50-7,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=925,,,AU_HCIS,1,CC1=C(C=CC(=C1)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/1732,PubChem,Cc1cc(O)ccc1Cl,Train,1,2702,training
-"NZ_CCID:
-Methionine","NZ_CCID:
-Racemethionine, Acimetion, Banthionine, Dyprin, Lobamine, Pedameth, DL-methionine",59-51-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0BC7DB3F-B410-40C7-A19D-A0B7D93DEEE0,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38
-[http://ptcl.chem.ox.ac.uk/MSDS/ME/dl-methionine.html]
-Eye Irritation
-R PHRASE: R 36
-[http://ptcl.chem.ox.ac.uk/MSDS/ME/dl-methionine.html]",,NZ_CCID,1,CSCCC(C(=O)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/876,PubChem,CSCCC(N)C(=O)O,Train,1,2702,training
-"EU_REACH:
-methyl 2-amino-4-[(2,5-dichlorophenyl)carbamoyl]benzoate",,59673-82-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11487/7/4/2/?documentUUID=ba093fef-a72a-46bc-8e19-d27d391f0aad,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=C(C=C(C=C1)C(=O)NC2=C(C=CC(=C2)Cl)Cl)N,https://pubchem.ncbi.nlm.nih.gov/compound/761588,PubChem,COC(=O)c1ccc(C(=O)Nc2cc(Cl)ccc2Cl)cc1N,Train,1,2702,training
-"NZ_CCID:
-2-Chlorophenyl 2,2,2-trichloroethyl chlorophosphate",,59819-52-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F06ED442-F194-4B93-A1EA-8A3F40338B8C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C(C(=C1)OP(=O)(OCC(Cl)(Cl)Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/108842,PubChem,O=P(Cl)(OCC(Cl)(Cl)Cl)Oc1ccccc1Cl,Train,1,2702,training
-"NZ_CCID:
-Bromoacetyl bromide",,598-21-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D6F838CA-5797-4C8D-B2C6-7951DB83973A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(C(=O)Br)Br,https://pubchem.ncbi.nlm.nih.gov/compound/61147,PubChem,O=C(Br)CBr,Train,1,2702,training
-"JP_CHRIP:
-bromoacetone","JP_CHRIP:
-Acetyl methyl bromide
-Bromo-2-propanone",598-31-2,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-1335e.html,"JP_CHRIP:
-It was set to category 2 from the description that stimulus on the human skin at serious degree (Severe), redness, and hurts were seen (ICSC(J)2005; HSDB, 2003; HSFS, 2002).",,JP_CHRIP,1,CC(=O)CBr,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.305G,J-GLOBAL,CC(=O)CBr,Train,1,2702,training
-"NZ_CCID:
-3-Butene-2-ol",,598-32-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2DAEBFE3-6299-4055-B1BE-B21324933B0B,"NZ_CCID:
-Skin Irritation
-R-Phrase: R 38 [CHEMWATCH]
-Eye Irritation
-REMARK: EYE The liquid is highly discomforting to the eyes and is capable of causing a mild, temporary redness of the conjunctiva (similar to wind-burn), temporary impairment of vision and/ or other transient eye damage/ ulceration. The vapour is discomforting to the eyes if exposure is prolonged.
-REFERENCE SOURCE: Chemwatch MSDS",,NZ_CCID,1,CC(C=C)O,https://pubchem.ncbi.nlm.nih.gov/compound/11716,PubChem,C=CC(C)O,Train,1,2702,training
-"JP_CHRIP:
-N,N-Dimethylethylamine
-
-NZ_CCID:
-Ethyldimethylamine","JP_CHRIP:
-Dimethylethylamine; N,N-Dimethylethylamine
-
-NZ_CCID:
-Dimethylethylamine, Ethanamine, N,N-dimethyl-, Ethylamine, N,N-dimethyl-, Methanamine, N-ethyl-N-methyl-, N,N-Dimethylethylamine, N-Ethyldimethylamine",598-56-1,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0148e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3C666EB4-727C-48DA-9B11-7CF646ADA2ED","JP_CHRIP:
-Because a test using rabbits resulted in corrosive (IUCLID (2000)) and pH is 12 (20 degrees C, 50 g/L) (GESTIS (Access on No. 2011)), it was classified in Category 1.
-Besides, it is classified in C; R34 in EU classification (EC-JRC (ESIS) (Access on Nov. 2011)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,"JP_CHRIP, NZ_CCID",2,CCN(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J60.917J,J-GLOBAL,CCN(C)C,Train,1,2702,training
-"NZ_CCID:
-2-Bromopropionic acid",,598-72-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5B3D8315-DDEC-40B0-A955-422E1643A5F6,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C(=O)O)Br,https://pubchem.ncbi.nlm.nih.gov/compound/11729,PubChem,CC(Br)C(=O)O,Train,1,2702,training
-"EU_REACH:
-N-butyrylalanine",,59875-04-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8167/7/4/2/?documentUUID=99bd21cd-e001-42e9-a0b5-19e1e0fec0bc,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC(=O)NC(C)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/11194480,PubChem,CCCC(=O)NC(C)C(=O)O,Train,1,2702,training
-"JP_CHRIP:
-2-Chloropropionic acid
-
-NZ_CCID:
-2-Chloropropionic acid","JP_CHRIP:
-2-Chloropropanoic acid
-2-Chloropropionic acid
-alpha-Chloropropionic acid
-Propanoic acid, 2-chloro-
-
-NZ_CCID:
-2-Chloropropanoic acid, Propanoic acid, 2-chloro-, Propionic acid, 2-chloro-",598-78-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2036e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4E340BFC-B821-4A40-9471-219F3EDFC033","JP_CHRIP:
-[Rationale for the Classification]
-It was classified in Category 1 from (1) - (3).
-
-[Evidence Data]
-(1) This substance was corrosive to the eye, skin, and respiratory tract, and contact with the skin or entry into the eye caused erythema, pain, and severe burns (ACGIH (7th, 2001), Environmental Risk Assessment for Chemical Substances vol. 13 (Ministry of the Environment, 2015)).
-(2) In a skin irritation test with rabbits on this substance, there was localized
-necrosis with later formation of a scab (GESTIS (Access on May 2020)).
-(3) The pH of this substance was < 1 (20 deg C) (GESTIS (Access on May 2020)).
-
-NZ_CCID:
-Skin Irritation
-UN #2511 UN CLASS: 8 PG III
-Eye Irritation
-R PHRASE: R 35 [Company Data]
-UN #2511 UN CLASS: 8 PG III",,"JP_CHRIP, NZ_CCID",2,CC(Cl)C(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J481B,J-GLOBAL,CC(Cl)C(=O)O,Train,1,2702,training
-"AU_HCIS:
-(S)-p-Mentha-1,8-diene
-
-NZ_CCID:
-(S)-(-)-Limonene","AU_HCIS:
-Dipentene
-Limonene
-l-Limonene
-
-NZ_CCID:
-l-limonene",5989-54-8,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4813
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D3357866-8EA1-48DF-85A7-4B52AA2B5FAE","NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,"AU_HCIS, NZ_CCID",2,CC1=CC[C@H](CC1)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/439250,PubChem,C=C(C)[C@@H]1CC=C(C)CC1,Train,1,2702,training
-"NZ_CCID:
-Methyl trichloroacetate",,598-99-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7877555B-41C5-4D00-8896-3B29D3A994D6,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,COC(=O)C(Cl)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11739,PubChem,COC(=O)C(Cl)(Cl)Cl,Train,1,2702,training
-"EU_REACH:
-N-{4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-2-methylprop-2-enamide",,59941-98-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21774/7/4/2/?documentUUID=6d7bc4b0-2c57-4bca-8b61-351803224880,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=NC(=N1)NS(=O)(=O)C2=CC=C(C=C2)NC(=O)C(=C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/13787754,PubChem,C=C(C)C(=O)Nc1ccc(S(=O)(=O)Nc2nc(C)cc(C)n2)cc1,Train,1,2702,training
-"EU_REACH:
-4-(2-phenylpropan-2-yl)phenol",,599-64-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2159/7/4/2/?documentUUID=15c33855-af95-4a3d-9ad2-1de96140a629,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C1=CC=CC=C1)C2=CC=C(C=C2)O,https://pubchem.ncbi.nlm.nih.gov/compound/11742,PubChem,CC(C)(c1ccccc1)c1ccc(O)cc1,Test,1,2702,training
-"NZ_CCID:
-2,3-Pentanedione, >1% in a non hazardous diluent
-
-US_HSDB:
-2,3-Pentanedione",,600-14-6,Cat 2,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/827B57F6-2E4D-4F7B-A7C2-4E614A862FF5
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8326",,,"NZ_CCID, US_HSDB",2,CCC(=O)C(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/11747,PubChem,CCC(=O)C(C)=O,Train,1,2702,training
-"NZ_CCID:
-2-Oxobutyric acid","NZ_CCID:
-2-ketobutyric acid",600-18-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D14EEDF2-02CF-4BF1-9B08-1BF9DEA61010,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCC(=O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/58,PubChem,CCC(=O)C(=O)O,Train,1,2702,training
-"NZ_CCID:
-Dithizone",,60-10-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A7A37736-6DB6-4CB1-87F3-5479F808CADD,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)NNC(=S)N=NC2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/657262,PubChem,S=C(N=Nc1ccccc1)NNc1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-p-Dimethylaminoazobenzene","JP_CHRIP:
-Benzenamine, N,N-dimethyl-4-(phenylazo)-
-Butter yellow
-N,N-Dimethyl-4-aminoazobenzene
-N,N-Dimethyl-4-phenylazobenzenamine
-N,N-Dimethyl-p-(phenylazo)aniline
-p-Dimethylaminoazobenzene
-para-Dimethylaminoazobenzene",60-11-7,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2007e.html,"JP_CHRIP:
-Based on the description that it was irritating to human skin and causes dermatitis (IARC 8 (1975), HSDB (Access on May 2017)), it was classified in Category 2.",,JP_CHRIP,1,CN(C)c1ccc(cc1)N=Nc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.922D,J-GLOBAL,CN(C)c1ccc(N=Nc2ccccc2)cc1,Train,1,2702,training
-"US_HSDB:
-GABAPENTIN",,60142-96-3,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/7364,,,US_HSDB,1,C1CCC(CC1)(CC(=O)O)CN,https://pubchem.ncbi.nlm.nih.gov/compound/3446,PubChem,NCC1(CC(=O)O)CCCCC1,Train,1,2702,training
-"EU_REACH:
-1-{[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl]methyl}-1H-1,2,4-triazole
-
-JP_CHRIP:
-1-{[2-(2,4-Dichlorophenyl)-4-propan-1-yl-1,3-dioxolan-2-yl]methyl}-1H-1,2,4-triazole (synonym: Propiconazole)","JP_CHRIP:
-Propiconazole",60207-90-1,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32104/7/4/2/?documentUUID=032faff4-e536-4712-b00a-592550e06898
-JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2026.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-【分類根拠】
-（１）～（３）より、区分に該当しない。
-
-【根拠データ】
-（１）ウサギ（n=3）を用いた皮膚刺激性試験（OECD TG404、GLP、閉塞、4時間適用、21日観察）において、除去1時間後、全例で軽度の紅斑が認められ、1週間後まで持続したが、3週間後には消失した。また、除去1時間後に、2匹で軽度の浮腫が認められ、うち1匹で48時間後まで持続した。皮膚一次刺激指数（PII）は1.22であった（紅斑・痂皮スコア：1/1/1、浮腫スコア：0/0/0.7）との報告がある（農薬抄録 (2015)、REACH登録情報 (Accessed Sep. 2021)）。
-（２）ウサギ（n=6）を用いた皮膚刺激性試験（閉塞、24時間適用、7日観察）において、適用1日後から軽度の紅斑及び浮腫が認められたが、4日後には消失した（紅斑・痂皮スコア：1/0.7/1/0.7/1.7/1.3、浮腫スコア：0.3/0.7/1/0.3/1.3/1）との報告がある（農薬抄録 (2015)）。
-（３）本物質は皮膚刺激性物質ではない（EFSA (2017)）。
-
-【参考データ等】
-（４）本物質はウサギの皮膚に対して刺激性を有する（JMPR (2004)）。
-（５）2系統のウサギを用いた皮膚刺激性試験で、軽度の刺激性がみられた（食安委 農薬評価書 (2017)）。
-（６）本物質は皮膚刺激性物質ではない（HSDB (Accessed Sep. 2021)）。",Provided,"EU_REACH, JP_CHRIP",2,CCCC1COC(Cn2cncn2)(O1)c1ccc(Cl)cc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J18.426H,J-GLOBAL,CCCC1COC(Cn2cncn2)(c2ccc(Cl)cc2Cl)O1,Train,1,2702,training
-"JP_CHRIP:
-2-Mercaptoethanol
-
-NZ_CCID:
-Ethanol, 2-mercapto-","JP_CHRIP:
-2-Hydroxyethanethiol
-2-mercaptethanol
-Monothioethyleneglycol
-Thioglycol
-
-NZ_CCID:
-1-Ethanol-2-thiol, 1-Hydroxy-2-mercaptoethane, 1-Mercapto-2-hydroxyethane, 2-Hydroxy-1-ethanethiol, 2-Hydroxyethanethiol, 2-Hydroxyethyl mercaptan, 2-ME, 2-Mercapto-1-ethanol, 2-Mercaptoethanol, 2-Mercaptoethyl alcohol, 2-Thioethanol, Ethylene glycol, monothio-, Hydroxyethyl mercaptan, Mercaptoethanol, Monothioethylene glycol, Monothioethyleneglycol, Monothioglycol, Thioethylene glycol, Thioglycol, Thiomonoglycol",60-24-2,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0076e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1E1EC77D-D326-4DA6-B4DC-D06C63E794F1","JP_CHRIP:
-Based on results of ""corrosive"" in 20-hour application test with rabbits and ""irritation"" (application period was not clear) (IUCLID (2000)), and a report that skin contact causes redness and pain (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 7 (2009)), the substance was classified into Category 2.
-
-NZ_CCID:
-Skin Irritation
-EXPERT JUDGEMENT: Classification based on weight of evidence.
-Eye Irritation
-EXPERT JUDGEMENT: Classification based on weight of evidence.",,"JP_CHRIP, NZ_CCID",2,OCCS,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.396J,J-GLOBAL,OCCS,Train,1,2702,training
-"NZ_CCID:
-3-Nitrophthalic acid",,603-11-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A7D73185-2B18-48C0-BD17-817E0BBD4A65,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C(=C1)[N+](=O)[O-])C(=O)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/69043,PubChem,O=C(O)c1cccc([N+](=O)[O-])c1C(=O)O,Train,1,2702,training
-"JP_CHRIP:
-Triphenylphosphine","JP_CHRIP:
-Triphenylphosphorous",603-35-0,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0200e.html,"JP_CHRIP:
-In the skin irritation test in rabbits in which 50% suspension of the substance in ethanol was occlusively applied for up to 1, 5, 15 minutes and 20 hours, 20-hour exposure caused mild erythema on the back and ears of the male rabbits after 24 hours, and symptoms disappeared in 7 days (SIDS (Access on Dec. 2010)). In another rabbit test in which treatment of suspension in olive oil (10%, 20% and 50%) for 20-hour, 20% suspension on the back caused very slight erythema after 1 and 2 days of application (symptoms disappeared in 3 days), and 50% suspension on the ears caused marked erythema associated with edema over 4 days (SIDS (Access on Dec. 2010)). It was also reported that open exposure of the substance caused ""slightly irritating"" by judging from the grade 3 for irritation (mean score was unclear) and ""moderately irritating"" by judging from the Draize score of 2.63 to 8.00 after 24 and 72 hours (SIDS (Access on Dec. 2010)). In the guinea pig test, the substance resulted as ""slightly irritating"" (SIDS (Access on Dec. 2010)). Based on these documents, the substance was classified as Category 2.",,JP_CHRIP,1,c1ccc(cc1)P(c1ccccc1)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.652G,J-GLOBAL,c1ccc(P(c2ccccc2)c2ccccc2)cc1,Train,1,2702,training
-"EU_REACH:
-4-[(4-aminophenyl)(phenyl)methyl]aniline",,603-40-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23945/7/4/2/?documentUUID=a8b3514e-9b86-4940-9a85-b8c5a533edb3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C(C2=CC=C(C=C2)N)C3=CC=C(C=C3)N,https://pubchem.ncbi.nlm.nih.gov/compound/69045,PubChem,Nc1ccc(C(c2ccccc2)c2ccc(N)cc2)cc1,Train,1,2702,training
-"EU_REACH:
-4-[(4-hydroxyphenyl)(pyridin-2-yl)methyl]phenol",,603-41-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11534/7/4/2/?documentUUID=e4d6ef64-c328-476a-ae53-560fcdd05a87,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=NC(=C1)C(C2=CC=C(C=C2)O)C3=CC=C(C=C3)O,https://pubchem.ncbi.nlm.nih.gov/compound/69046,PubChem,Oc1ccc(C(c2ccc(O)cc2)c2ccccn2)cc1,Train,1,2702,training
-"EU_REACH:
-3-benzyloxane",,60466-73-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31625/7/4/2/?documentUUID=1d53a999-337c-4142-8362-7adb3b23ceed,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC(COC1)CC2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/12284886,PubChem,c1ccc(CC2CCCOC2)cc1,Train,1,2702,training
-"NZ_CCID:
-5-Dimethylaminonaphthalene-1-sulphonyl chloride","NZ_CCID:
-dansyl chloride",605-65-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C348073E-59B8-446F-8EF7-0C57A0C8DC29,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CN(C)C1=CC=CC2=C1C=CC=C2S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11801,PubChem,CN(C)c1cccc2c(S(=O)(=O)Cl)cccc12,Train,1,2702,training
-"EU_CLP:
-4-bromo-2-chlorofluorobenzene",,60811-21-4,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC(=C(C=C1Br)Cl)F,https://pubchem.ncbi.nlm.nih.gov/compound/3543065,PubChem,Fc1ccc(Br)cc1Cl,Test,1,2702,training
-"EU_REACH:
-1-chloro-2,3-dimethylbenzene",,608-23-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25181/7/4/2/?documentUUID=05117a6e-282a-4ddb-b842-78d4029a7b7d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(=CC=C1)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/32884,PubChem,Cc1cccc(Cl)c1C,Train,1,2702,training
-"AU_HCIS:
-Benzenamine, 2,3-dichloro-",,608-27-5,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5621,,,AU_HCIS,1,C1=CC(=C(C(=C1)Cl)Cl)N,https://pubchem.ncbi.nlm.nih.gov/compound/11844,PubChem,Nc1cccc(Cl)c1Cl,Train,1,2702,training
-"NZ_CCID:
-2,6-Dibromophenol",,608-33-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/63E0041F-08DC-4FE2-978A-346008C47192,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C(=C1)Br)O)Br,https://pubchem.ncbi.nlm.nih.gov/compound/11847,PubChem,Oc1c(Br)cccc1Br,Train,1,2702,training
-"NZ_CCID:
-4-Pentynoic acid",,6089-09-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F4059E50-8DD3-4264-93E3-68E07F9271CB,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C#CCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/22464,PubChem,C#CCCC(=O)O,Train,1,2702,training
-"NZ_CCID:
-Ethyl 2-chloroacetoacetate",,609-15-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9314C717-69EB-4D9F-A7C2-ED2A0CA0C571,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCOC(=O)C(C(=O)C)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11858,PubChem,CCOC(=O)C(Cl)C(C)=O,Train,1,2702,training
-"NZ_CCID:
-2-Chlorobenzoyl chloride",,609-65-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F814D8ED-809B-44E2-B356-A1A7510429EC,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)C(=O)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/69110,PubChem,O=C(Cl)c1ccccc1Cl,Train,1,2702,training
-"NZ_CCID:
-2-Iodobenzoyl chloride",,609-67-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8BD3D388-99FD-4EAC-A304-597A10F19250,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)C(=O)Cl)I,https://pubchem.ncbi.nlm.nih.gov/compound/69112,PubChem,O=C(Cl)c1ccccc1I,Train,1,2702,training
-"NZ_CCID:
-2-Propenamide, N,N'-(dithiodi-2,1-ethanediyl)bis-",,60984-57-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2580254D-DBED-4DD9-9389-3BDDCBC57F21,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 38. [Chemwatch].
-Eye Irritation
-R-PHRASE: R 36. [Chemwatch].",,NZ_CCID,1,C=CC(=O)NCCSSCCNC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/100602,PubChem,C=CC(=O)NCCSSCCNC(=O)C=C,Train,1,2702,training
-"NZ_CCID:
-2-Nitrobenzoyl chloride",,610-14-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/14D42FAC-28F8-4DD6-AD50-1F66E57B38BD,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C(C(=C1)C(=O)Cl)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/11875,PubChem,O=C(Cl)c1ccccc1[N+](=O)[O-],Train,1,2702,training
-"NZ_CCID:
-4-Nitrophthalic acid, >10% in a non hazardous diluent","NZ_CCID:
-4-nitrophthalic acid",610-27-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E9580CBE-0C0F-4F06-8375-ED5D1DE8EF97,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C=C1[N+](=O)[O-])C(=O)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/69121,PubChem,O=C(O)c1ccc([N+](=O)[O-])cc1C(=O)O,Train,1,2702,training
-"NZ_CCID:
-2,4-Dinitrobenzyl chloride",,610-57-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/702BDEBA-3ACF-48F1-BE04-6FF47D699DD2,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])CCl,https://pubchem.ncbi.nlm.nih.gov/compound/69125,PubChem,O=[N+]([O-])c1ccc(CCl)c([N+](=O)[O-])c1,Train,1,2702,training
-"NZ_CCID:
-4-Chloro-3-nitrophenol",,610-78-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1338A92E-B205-4252-9C2D-771E1AE2C618,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C=C1O)[N+](=O)[O-])Cl,https://pubchem.ncbi.nlm.nih.gov/compound/69127,PubChem,O=[N+]([O-])c1cc(O)ccc1Cl,Train,1,2702,training
-"JP_CHRIP:
-2,4-Dichloro-1-nitrobenzene","JP_CHRIP:
-2,4-Dichloronitrobenzene
-2,4-dichloronitrobenzene
-Benzene, 2,4-dichloro-1-nitro-",611-06-3,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-meti-0075e.html,"JP_CHRIP:
-Based on descriptions ""Slightly irritating"" (SIDS (1996)) in the patch test with rabbits and ""Slightly irritating"" (IUCLID (2000)) in the skin irritation/corrosion test (OECD TG 404, GLP), it was classified into ""Not classified"".",Provided,JP_CHRIP,1,[O-][N+](=O)c1ccc(Cl)cc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.081H,J-GLOBAL,O=[N+]([O-])c1ccc(Cl)cc1Cl,Train,1,2702,training
-"NZ_CCID:
-2-Chlorobenzyl bromide",,611-17-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9B351CB9-014A-42BB-8D23-CE73E7CE3D35,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 41 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 34 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C(C(=C1)CBr)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11905,PubChem,Clc1ccccc1CBr,Train,1,2702,training
-"NZ_CCID:
-2-Hydroxybenzonitrile","NZ_CCID:
-2-cyanophenol",611-20-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8FEADF14-F68B-4842-9C3B-1E1599578F31,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)C#N)O,https://pubchem.ncbi.nlm.nih.gov/compound/11907,PubChem,N#Cc1ccccc1O,Train,1,2702,training
-"EU_REACH:
-[(2R,4R)-2-(bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methyl benzoate",,61397-56-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24206/7/4/2/?documentUUID=79c23041-3e52-4153-a160-f33639e0948c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1[C@@H](O[C@@](O1)(CBr)C2=C(C=C(C=C2)Cl)Cl)COC(=O)C3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/1390983,PubChem,O=C(OC[C@H]1CO[C@](CBr)(c2ccc(Cl)cc2Cl)O1)c1ccccc1,Train,1,2702,training
-"EU_REACH:
-(Z)-hex-3-enyl (Z)-hex-3-enoate",,61444-38-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11788/7/4/2/?documentUUID=ad650677-0685-431d-9c59-61b72e4230ad,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC/C=C\CCOC(=O)C/C=C\CC,https://pubchem.ncbi.nlm.nih.gov/compound/6435882,PubChem,CC/C=C\CCOC(=O)C/C=C\CC,Train,1,2702,training
-"EU_REACH:
-2-hydroxybenzimidazole",,615-16-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1876/7/4/2/?documentUUID=81bfde42-bf03-454b-8ea8-5c5b46e58009,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)NC(=O)N2,https://pubchem.ncbi.nlm.nih.gov/compound/11985,PubChem,O=c1[nH]c2ccccc2[nH]1,Train,1,2702,training
-"NZ_CCID:
-2-Chloro-1-iodobenzene","NZ_CCID:
-1-chloro-2-iodobenzene",615-41-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6D6F7AF4-2884-4CD4-BEB2-D9A2D7D32568,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)Cl)I,https://pubchem.ncbi.nlm.nih.gov/compound/11993,PubChem,Clc1ccccc1I,Train,1,2702,training
-"JP_CHRIP:
-ethyl methylnitrosocarbamate","JP_CHRIP:
-Carbamic acid, methylnitroso-, ethyl ester
-Ethyl N-methyl-N-nitrosocarbamate
-N-Methyl-N-nitrosourethane",615-53-2,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0973e.html,"JP_CHRIP:
-There is no concrete case report. But from description that a blister is made by contact (PATTY (4th, 1994)), it was judged that there was skin irritation, and it was set as Category 2.",,JP_CHRIP,1,CCOC(=O)N(C)N=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.659D,J-GLOBAL,CCOC(=O)N(C)N=O,Train,1,2702,training
-"JP_CHRIP:
-2,4-Dibromophenol",,615-58-7,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0163e.html,"JP_CHRIP:
-A test applied undiluted this substance to rabbit skin for 24 hours reported slight hyperemia with moderate edema (CICAD 66 (2005)). And there is the information that it is irritating to the skin (HSDB (2009)).
-Therefore it was classified in Category 2.",,JP_CHRIP,1,Oc1ccc(Br)cc1Br,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J60.202G,J-GLOBAL,Oc1ccc(Br)cc1Br,Train,1,2702,training
-"EU_REACH:
-4-chloro-1,2-dimethylbenzene",,615-60-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5679/7/4/2/?documentUUID=78ba5bec-caf0-4016-9cee-584f213d4c73,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/32886,PubChem,Cc1ccc(Cl)cc1C,Test,1,2702,training
-"EU_REACH:
-2,2-bis(methylthio)propane",,6156-18-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30186/7/4/2/?documentUUID=90165d62-9c45-43f1-b9f1-556abfcefaef,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1NC(=S)NC2=CC=C(C=C2)S(=O)(=O)N)F,https://pubchem.ncbi.nlm.nih.gov/compound/730546,PubChem,NS(=O)(=O)c1ccc(NC(=S)Nc2ccc(F)cc2)cc1,Train,1,2702,training
-"NZ_CCID:
-2-Chloro-5-methylphenol","NZ_CCID:
-6-chloro-m-cresol",615-74-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5ED0679E-301F-44BE-BF0C-A1B0F3CD3B5E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CC1=CC(=C(C=C1)Cl)O,https://pubchem.ncbi.nlm.nih.gov/compound/12008,PubChem,Cc1ccc(Cl)c(O)c1,Train,1,2702,training
-"NZ_CCID:
-Ethyl 2-bromovalerate",,615-83-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D563D9FE-1033-4253-9188-7E91CBFACD7E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCCC(C(=O)OCC)Br,https://pubchem.ncbi.nlm.nih.gov/compound/79071,PubChem,CCCC(Br)C(=O)OCC,Train,1,2702,training
-"EU_REACH:
-2-methylpropyl-(R)-2-hydroxypropanoate",,61597-96-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17048/7/4/2/?documentUUID=7233fa5d-6aa9-4dea-b7ee-f3fc8c5326bc,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@H](C(=O)OCC(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/10486989,PubChem,CC(C)COC(=O)[C@@H](C)O,Train,1,2702,training
-"NZ_CCID:
-Tri(o-tolyl)-phosphine","NZ_CCID:
-tri-o-tolylphosphine",6163-58-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C81F065F-1BCC-4A8B-A67C-BD20BA03FE89,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=CC=CC=C1P(C2=CC=CC=C2C)C3=CC=CC=C3C,https://pubchem.ncbi.nlm.nih.gov/compound/80271,PubChem,Cc1ccccc1P(c1ccccc1C)c1ccccc1C,Train,1,2702,training
-"EU_REACH:
-pyrrolidin-2-one",,616-45-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14900/7/4/2/?documentUUID=5fd1a28e-c0b4-442a-a60a-c3575137ec53,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC(=O)NC1,https://pubchem.ncbi.nlm.nih.gov/compound/12025,PubChem,O=C1CCCN1,Train,1,2702,training
-"NZ_CCID:
-2-Aminopropanol","NZ_CCID:
-DL-2-Amino-1-propanol, DL-alaninol",6168-72-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B09112CF-7FE8-4FFB-A043-80DC0D4B1D19,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 34. [Company data]
-Eye Irritation
-R-PHRASE: R 34. [Company data]",,NZ_CCID,1,CC(CO)N,https://pubchem.ncbi.nlm.nih.gov/compound/5126,PubChem,CC(N)CO,Train,1,2702,training
-"EU_CLP:
-4-fluoro-3-trifluoromethylphenol",,61721-07-1,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC(=C(C=C1O)C(F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/601854,PubChem,Oc1ccc(F)c(C(F)(F)F)c1,Test,1,2702,training
-"KR_NCIS:
-Methyl 2-propynyl carbonate",,61764-71-4,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,COC(=O)OCC#C,https://pubchem.ncbi.nlm.nih.gov/compound/10898684,PubChem,C#CCOC(=O)OC,Train,1,2702,training
-"NZ_CCID:
-3-Ethylpentane",,617-78-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/57E20B29-E96B-4E45-8740-F1F766DEE40B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]",,NZ_CCID,1,CCC(CC)CC,https://pubchem.ncbi.nlm.nih.gov/compound/12048,PubChem,CCC(CC)CC,Train,1,2702,training
-"AU_HCIS:
-amines, hydrogenated tallow alkyl","AU_HCIS:
-hydrogenated tallow alkyl amines
-tallow amine (hard)",61788-45-2,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4771,,,AU_HCIS,1,CCCCCCCCCCCCCCCCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/15793,PubChem,CCCCCCCCCCCCCCCCCCN,Train,1,2702,training
-"EU_REACH:
-(11Z)-10-octyl-11-octylideneicosanedioic acid; 8-[1-(7-carboxyheptyl)-5,6-dipentyl-1,2,4a,5,6,8a-hexahydronaphthalen-2-yl]octanoic acid; 9-[2-(8-carboxyoctyl)-6-[(1E)-hept-1-en-1-yl]-5-pentylcyclohex-3-en-1-yl]nonanoic acid; 9-[6-(8-carboxyoctyl)-2-[(1E)-hept-1-en-1-yl]-3-pentylphenyl]nonanoic acid",,61788-89-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16133/7/4/2/?documentUUID=7c527504-bda8-4d2a-b7fa-0448abc85043,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCC(CCCCCCCCC(=O)O)C(CCCCCCCC(=O)O)CC/C=C\CCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/22833342,PubChem,CCCCC/C=C\CCC(CCCCCCCC(=O)O)C(CCCCCCCC)CCCCCCCCC(=O)O,Train,1,2702,training
-"AU_HCIS:
-Amines, coco alkyldimethyl
-
-NZ_CCID:
-Amines, coco alkyldimethyl",,61788-93-0,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5004
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/39138975-DCE7-4CFE-A91F-48A52CF50E69","NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,"AU_HCIS, NZ_CCID",2,CC(C)(C)OC(=O)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/312724,PubChem,CN(C)C(=O)OC(C)(C)C,Train,1,2702,training
-"NZ_CCID:
-Furfurylamine",,617-89-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CA1211EC-86E1-4672-A3AF-E48EA5F50C57,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=COC(=C1)CN,https://pubchem.ncbi.nlm.nih.gov/compound/3438,PubChem,NCc1ccco1,Train,1,2702,training
-"EU_REACH:
-2-{2-[(8Z)-heptadec-8-en-1-yl]-4,5-dihydro-1H-imidazol-1-yl}ethan-1-ol; 2-{2-[(8Z)-heptadec-8-en-1-yl]-4,5-dihydro-1H-imidazol-1-yl}ethyl (9Z)-octadec-9-enoate",,61791-39-7,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5449/7/4/2/?documentUUID=0d91ab2b-640f-4fe8-9412-0a57c858a6a8,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CN(C=N1)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/155133,PubChem,OCCN1C=NCC1,Train,1,2702,training
-"NZ_CCID:
-2-Phenyl-2-propanol","NZ_CCID:
-1-hydroxycumene, 2-phenylisopropanol, dimethylphenylcarbinol, dimethylphenylmethanol",617-94-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E34BC78D-76B2-4D23-8FB2-724359D58752,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]",,NZ_CCID,1,CC(C)(C1=CC=CC=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/12053,PubChem,CC(C)(O)c1ccccc1,Train,1,2702,training
-"EU_REACH:
-(2S)-2-hydroxy-2-(3-phenoxyphenyl)acetonitrile",,61826-76-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27665/7/4/2/?documentUUID=1c7b1d95-04dd-4866-bca7-42f0f963f5ad,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)OC2=CC=CC(=C2)[C@@H](C#N)O,https://pubchem.ncbi.nlm.nih.gov/compound/9837437,PubChem,N#C[C@@H](O)c1cccc(Oc2ccccc2)c1,Train,1,2702,training
-"NZ_CCID:
-Benzoyl bromide",,618-32-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BC116D4D-F293-4722-BBC7-39D1C3D807C9,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)C(=O)Br,https://pubchem.ncbi.nlm.nih.gov/compound/12056,PubChem,O=C(Br)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-1-Phenylethylamine","NZ_CCID:
-DL-1-Phenylethylamine",618-36-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/76BB4E2D-9E04-4051-B43B-A2E1181AFCBC,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 34. [Company data]
-Eye Irritation
-R-PHRASE: R 34. [Company data]",,NZ_CCID,1,CC(C1=CC=CC=C1)N,https://pubchem.ncbi.nlm.nih.gov/compound/7408,PubChem,CC(N)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-3-Chlorobenzoyl chloride",,618-46-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B02EB081-8F02-4776-8DEC-27C84F2E1986,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)Cl)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/69252,PubChem,O=C(Cl)c1cccc(Cl)c1,Train,1,2702,training
-"JP_CHRIP:
-2,5-Dinitrotoluene","JP_CHRIP:
-2,5-Dinitrotoluene; 2,5-Dinitrotoluene
-2,5-DNT
-2-Methyl-1,4-dinitrobenzene
-Benzene, 2-methyl-1,4-dinitro-
-Toluene, 2,5-dinitro-",619-15-8,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2013e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified in Category 2 from (1), (2). The classification result was changed due to new data obtained.
-
-[Evidence Data]
-(1) This substance was moderately irritating in a skin irritation test with rabbits (Draize test) (Risk Assessment Report (Ministry of Health, Labour and Welfare, 2009), MAK (DFG) vol.6 (1994), ACGIH (7th, 2001)).
-(2) This substance caused slight to moderate irritation in a skin irritation test with rabbits according to a modified Draize test (GESTIS (Access on April 2020)).",,JP_CHRIP,1,Cc1cc(ccc1[N+](=O)[O-])[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J7.041F,J-GLOBAL,Cc1cc([N+](=O)[O-])ccc1[N+](=O)[O-],Train,1,2702,training
-"EU_REACH:
-2-ethylhexyl 2-cyano-3,3-diphenylacrylate",,6197-30-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14858/7/4/2/?documentUUID=0ba6c8d0-e0f5-42b6-b4d7-14d3aedc2f22,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)C(=C(C1=CC=CC=C1)C2=CC=CC=C2)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/22571,PubChem,CCCCC(CC)COC(=O)C(C#N)=C(c1ccccc1)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-3-Ethylhexane","NZ_CCID:
-Hexane, 3-ethyl-",619-99-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/68F365D2-DD5B-4578-A343-77DD39A17F21,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [ECB]",,NZ_CCID,1,CCCC(CC)CC,https://pubchem.ncbi.nlm.nih.gov/compound/12096,PubChem,CCCC(CC)CC,Train,1,2702,training
-"NZ_CCID:
-3-Methylbenzyl chloride",,620-19-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9A9C74F1-5DCB-47CD-B143-FEEFBBA53230,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=CC(=CC=C1)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/12102,PubChem,Cc1cccc(CCl)c1,Train,1,2702,training
-"NZ_CCID:
-4-(Dimethylamino)-cinnamaldehyde","NZ_CCID:
-p-dimethylaminocinnamaldehyde",6203-18-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E8430C23-E28F-4140-95B2-C01B9D281E24,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CN(C)C1=CC=C(C=C1)/C=C/C=O,https://pubchem.ncbi.nlm.nih.gov/compound/5284506,PubChem,CN(C)c1ccc(/C=C/C=O)cc1,Train,1,2702,training
-"NZ_CCID:
-Tribenzylamine",,620-40-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6454335F-DBB0-4CB9-8E6A-EC063FFD42F5,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)CN(CC2=CC=CC=C2)CC3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/24321,PubChem,c1ccc(CN(Cc2ccccc2)Cc2ccccc2)cc1,Train,1,2702,training
-"US_HSDB:
-Bisphenol F",,620-92-8,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8091,,,US_HSDB,1,C1=CC(=CC=C1CC2=CC=C(C=C2)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/12111,PubChem,Oc1ccc(Cc2ccc(O)cc2)cc1,Train,1,2702,training
-"NZ_CCID:
-(3-Hydroxyphenyl)-acetic acid","NZ_CCID:
-3-hydroxyphenylacetic acid",621-37-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F1A85883-AF36-4671-B384-023E5904894D,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)O)CC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/12122,PubChem,O=C(O)Cc1cccc(O)c1,Train,1,2702,training
-"NZ_CCID:
-3-Acetamidophenol",,621-42-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B35A0AC3-6550-497D-B0C6-9C46D136A52C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(=O)NC1=CC(=CC=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/12124,PubChem,CC(=O)Nc1cccc(O)c1,Train,1,2702,training
-"JP_CHRIP:
-p-Nitrobenzoic acid","JP_CHRIP:
-p-nitrobenzoic acid
-para-Carboxynitrobenzene
-para-Nitrobenzoic acid",62-23-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-2052e.html,"JP_CHRIP:
-It was classified as ""Not classified"" because it is reported that there was no irritation in a test with rabbits (OECD TG 404) (IUCLID (2000)).",Provided,JP_CHRIP,1,OC(=O)c1ccc(cc1)[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.346I,J-GLOBAL,O=C(O)c1ccc([N+](=O)[O-])cc1,Train,1,2702,training
-"NZ_CCID:
-Benzoic acid, 4-(bromomethyl)-",,6232-88-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/000DCBF7-A211-4F62-8363-196694567F43,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC(=CC=C1CBr)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/22599,PubChem,O=C(O)c1ccc(CBr)cc1,Train,1,2702,training
-"EU_REACH:
-N-pentan-2-ylidenehydroxylamine",,623-40-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14551/7/4/2/?documentUUID=47fd4ebd-9940-43de-bf36-045ba84072e8,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC(=NO)C,https://pubchem.ncbi.nlm.nih.gov/compound/136433,PubChem,CCCC(C)=NO,Train,1,2702,training
-"NZ_CCID:
-Methyl crotonate",,623-43-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/56FD878A-768C-4DAF-9EC4-C1D2DCB43BA2,"NZ_CCID:
-Skin Irritation
-REMARK: SKIN: The liquid may produce skin discomfort following prolonged contact. Defatting and/or drying of the skin may lead to dermatitis. The material may accentuate any pre-existing skin condition. The material may cause
-Skin Irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of vesicles, scaling and thickening of the skin.
-REFERENCE SOURCE: Chemwatch MSDS
-Eye Irritation
-REMARK: EYE: The liquid is discomforting to the eyes and is capable of causing a mild, temporary redness of the conjunctiva (similar to wind-burn), temporary impairment of vision and/ or other transient eye damage/ ulceration.
-REFERENCE SOURCE: Chemwatch MSDS",,NZ_CCID,1,C/C=C/C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/638132,PubChem,C/C=C/C(=O)OC,Train,1,2702,training
-"NZ_CCID:
-Ethyl acetylenecarboxylate","NZ_CCID:
-ethyl propiolate",623-47-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D466C557-AECC-4994-9A00-F1EFE46FD5DD,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 36 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCOC(=O)C#C,https://pubchem.ncbi.nlm.nih.gov/compound/12182,PubChem,C#CC(=O)OCC,Train,1,2702,training
-"NZ_CCID:
-Ethyl iodoacetate",,623-48-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C9BE8CB2-E27A-4A3E-BCE5-D2DC7239699C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCOC(=O)CI,https://pubchem.ncbi.nlm.nih.gov/compound/12183,PubChem,CCOC(=O)CI,Train,1,2702,training
-"NZ_CCID:
-Ethyl cyanoformate",,623-49-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/837F908F-9B9B-4510-84E9-8809C49F44B3,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCOC(=O)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/69336,PubChem,CCOC(=O)C#N,Train,1,2702,training
-"NZ_CCID:
-Ethyl thioglycolate",,623-51-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D0FC63E4-4F56-47D2-A1A2-5EE964590CDD,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCOC(=O)CS,https://pubchem.ncbi.nlm.nih.gov/compound/12185,PubChem,CCOC(=O)CS,Train,1,2702,training
-"NZ_CCID:
-Ethyl crotonate","NZ_CCID:
-Ethyl trans-2-butenoate",623-70-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3F390950-9E31-46D1-BFBC-3E065CC941D1,,,NZ_CCID,1,CCOC(=O)/C=C/C,https://pubchem.ncbi.nlm.nih.gov/compound/429065,PubChem,C/C=C/C(=O)OCC,Train,1,2702,training
-"NZ_CCID:
-Ethyl 3-chloropropionate",,623-71-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8F0F7573-DAE8-4F6E-821F-7E90CFA4998A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCOC(=O)CCCl,https://pubchem.ncbi.nlm.nih.gov/compound/69341,PubChem,CCOC(=O)CCCl,Train,1,2702,training
-"NZ_CCID:
-2,5-Dibromopyridine",,624-28-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0A4C6DF6-C849-4980-8A20-EA3118695327,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=NC=C1Br)Br,https://pubchem.ncbi.nlm.nih.gov/compound/69353,PubChem,Brc1ccc(Br)nc1,Train,1,2702,training
-"NZ_CCID:
-4-Iodotoluene",,624-31-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4A01F328-400B-485D-9065-5736016E10AA,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=CC=C(C=C1)I,https://pubchem.ncbi.nlm.nih.gov/compound/12207,PubChem,Cc1ccc(I)cc1,Train,1,2702,training
-"JP_CHRIP:
-2-Methylbutyl acetate","JP_CHRIP:
-2-Methylbutyl acetate",624-41-9,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2121e.html,"JP_CHRIP:
-Although no specific data were available, since there is a description that all amyl acetate compounds, including this substance, were irritating to the skin (ACGIH (7th, 2001)), it was classified in Category 2. Besides, there is a report that no irritation was observed after repeated occlusive application of an isomer mixture of this substance to 197 test persons (DFGOT vol. 11 (1996)). In addition, there is a report that slight irritation was observed after application of an isomer mixture containing this substance to the ears of rabbits, and there is a description that after 4-hour non-occlusive application of 0.5 mL of the isomer mixture to rabbits, moderate erythema and slight edema were observed, and slight desquamation was observed 7 days after application (DFGOT vol. 11 (1996)). Information in ACGIH (7th, 2001) was added and the category was changed.",,JP_CHRIP,1,CCC(C)COC(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J95.657K,J-GLOBAL,CCC(C)COC(C)=O,Train,1,2702,training
-"EU_CLP:
-N,N-diethyl-N',N'-dimethylpropan-1,3-diyl-diamine",,62478-82-4,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCN(CC)CCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/40429057,PubChem,CCN(CC)CCCN(C)C,Test,1,2702,training
-"EU_CLP:
-methyl isocyanate",,624-83-9,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CN=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/12228,PubChem,CN=C=O,Test,1,2702,training
-"JP_CHRIP:
-ethyl methanesulphonate","JP_CHRIP:
-Ethyl methanesulfonate",62-50-0,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0958e.html,"JP_CHRIP:
-There was no concrete case report. But it was set as Category 2 from description that the skin might be stimulated by contact (HSFS (2000)), and description that the skin was stimulated (SITTIG (4th, 2002)).",,JP_CHRIP,1,CCOS(=O)(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.927E,J-GLOBAL,CCOS(C)(=O)=O,Train,1,2702,training
-"NZ_CCID:
-3-Chloropropionyl chloride",,625-36-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7E95DD00-969C-4EEB-B51D-0F6E697E088E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 35 [Company Data]
-Eye Irritation
-R PHRASE: R 35 [Company Data]",,NZ_CCID,1,C(CCl)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/69364,PubChem,O=C(Cl)CCCl,Train,1,2702,training
-"AU_HCIS:
-methoxyacetic acid
-
-JP_CHRIP:
-methoxyacetic acid
-
-NZ_CCID:
-Methoxyacetic acid","AU_HCIS:
-Acetic acid, methoxy-
-
-JP_CHRIP:
-Acetic acid, 2-methoxy-
-
-NZ_CCID:
-2-Methoxyacetic acid, Acetic acid, methoxy-, Methoxyethanoic acid",625-45-6,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=2863
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0122e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/00799901-1D93-453D-825A-2EDEB849DAFB","JP_CHRIP:
-Since it is documented that the substance was corrosive to rabbit skin (ECETOC TR95 vol. 2 (1995)), its pH value was 1.6 (100 g/L) (GESTIS (accessed in August 2008)), and it is rated R34 in the EU classification, the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,COCC(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J502I,J-GLOBAL,COCC(=O)O,Train,1,2702,training
-"NZ_CCID:
-2-Nitroethanol, >10% in a non hazardous diluent","NZ_CCID:
-2-nitroethanol",625-48-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FA6CABF9-C595-444C-90E9-A9E28518F8C9,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(CO)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/12252,PubChem,O=[N+]([O-])CCO,Train,1,2702,training
-"AU_HCIS:
-thioacetamide
-
-NZ_CCID:
-Thioacetamide","AU_HCIS:
-Ethanethioamide",62-55-5,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4485
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/52443563-9A99-440D-951C-E2CDA70FCA49","NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,"AU_HCIS, NZ_CCID",2,CC(=S)N,https://pubchem.ncbi.nlm.nih.gov/compound/2723949,PubChem,CC(N)=S,Train,1,2702,training
-"NZ_CCID:
-3,5-Dibromopyridine",,625-92-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/48DB9D0D-A45A-42C9-9290-475140D8A968,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=C(C=NC=C1Br)Br,https://pubchem.ncbi.nlm.nih.gov/compound/69369,PubChem,Brc1cncc(Br)c1,Train,1,2702,training
-"NZ_CCID:
-2,6-Dibromopyridine",,626-05-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/35A519A5-2D1A-4DA0-AB83-44E359A4CB43,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=NC(=C1)Br)Br,https://pubchem.ncbi.nlm.nih.gov/compound/12274,PubChem,Brc1cccc(Br)n1,Train,1,2702,training
-"NZ_CCID:
-1,3-Bis(bromomethyl)-benzene","NZ_CCID:
-m-xylylene dibromide",626-15-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0EC46795-7FA2-4F0D-B63E-23891A85E361,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)CBr)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/69373,PubChem,BrCc1cccc(CBr)c1,Train,1,2702,training
-"NZ_CCID:
-1,3-Bis(chloromethyl)-benzene","NZ_CCID:
-m-xylylene dichloride",626-16-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B3F3BD67-4D1E-4734-8ADB-3E31608B0FC9,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)CCl)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/12275,PubChem,ClCc1cccc(CCl)c1,Train,1,2702,training
-"NZ_CCID:
-3-Bromopyridine",,626-55-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6ECB7E72-646E-4A12-9C89-75CAA7C469F7,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CN=C1)Br,https://pubchem.ncbi.nlm.nih.gov/compound/12286,PubChem,Brc1cccnc1,Train,1,2702,training
-"NZ_CCID:
-4-Methylpiperidine",,626-58-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A66333B3-6623-4742-BD78-98CEAFD99D28,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC1CCNCC1,https://pubchem.ncbi.nlm.nih.gov/compound/69381,PubChem,CC1CCNCC1,Train,1,2702,training
-"NZ_CCID:
-3-Chloropyridine
-
-US_HSDB:
-3-Chloropyridine",,626-60-8,Cat 2,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9950FCA4-B78D-4DAA-826A-64A7467EB546
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8485","NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,"NZ_CCID, US_HSDB",2,C1=CC(=CN=C1)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/12287,PubChem,Clc1cccnc1,Train,1,2702,training
-"JP_CHRIP:
-1-Methylpiperidine
-
-NZ_CCID:
-Piperidine, 1-methyl-","JP_CHRIP:
-N-methylpiperidine
-
-NZ_CCID:
-1-Methylpiperidine, N-Methylpiperidine",626-67-5,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0205e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/930EF764-78B5-40AD-8F00-CDACF97BF175","JP_CHRIP:
-Since the substance has a pH of 12 (100 g/L, 20 degC) (GESTIS (access on Sep. 2009)), the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-UN CLASS: 8, PG II
-Eye Irritation
-UN CLASS: 8, PG II",,"JP_CHRIP, NZ_CCID",2,CN1CCCCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J39.106I,J-GLOBAL,CN1CCCCC1,Train,1,2702,training
-"NZ_CCID:
-Ethoxyacetic acid","NZ_CCID:
-Acetic acid, ethoxy-",627-03-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2FB64DD9-E0CF-41D8-A828-7A2F751FE90A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCOCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/12301,PubChem,CCOCC(=O)O,Train,1,2702,training
-"EU_REACH:
-4'-chloro-2-nitrobiphenyl",,6271-80-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5379/7/4/2/?documentUUID=cb0bc74d-024d-4c2e-bcc9-277c3ee835f6,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=C1)C2=CC=C(C=C2)Cl)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/235549,PubChem,O=[N+]([O-])c1ccccc1-c1ccc(Cl)cc1,Train,1,2702,training
-"NZ_CCID:
-3-Bromo-1-propanol",,627-18-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/34E71AC9-3647-470A-9DDD-46CFD6120453,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(CO)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/12308,PubChem,OCCCBr,Train,1,2702,training
-"NZ_CCID:
-1-Pentyne",,627-19-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/52262F8F-9CFC-455F-9CC3-647EEC02EFAD,"NZ_CCID:
-Skin Irritation
-REMARK: Irritating to skin
-SOURCE: Sigma Aldrich
-REMARK: Liquid may produce skin discomfort following prolonged contact. Defatting and/or drying of the skin may lead to dermatitis. The material may accentuate any pre-existing skin condition. Open cuts, abraded or irritated skin should not be exposed to this material.
-SOURCE: Chemwatch
-Eye Irritation
-REMARK: Irritating to eyes
-SOURCE: Sigma Aldrich
-REMARK: The vapour and liquid both produce eye discomfort. Tearing and reddening of the eyes are symptomatic of overexposure. Higher levels of vapour are generated with increased temperature and engineering controls should be introduced when any discomfort is experienced following exposure to mists or vapour.
-SOURCE: Chemwatch",,NZ_CCID,1,CCCC#C,https://pubchem.ncbi.nlm.nih.gov/compound/12309,PubChem,C#CCCC,Train,1,2702,training
-"NZ_CCID:
-2-Pentyne",,627-21-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1172E9B9-695B-408E-9DDE-E938BC85D453,"NZ_CCID:
-Skin Irritation
-REMARK: may produce skin discomfort following prolonged contact. Defatting and/or drying of the skin may lead to dermatitis. May accentuate any pre-existing skin conditions.
-REFERENCE SOURCE: [Chemwatch]
-Eye Irritation
-REMARK: The vapour and liquid both produce eye discomfort. Tearing and reddening of the eyes are symptomatic of overexposure. Higher levels of vapour are generated with increased temperature and engineering controls should be introduced when any discomfort is experienced following exposure to mists or vapour.
-REFERENCE SOURCE: [Chemwatch]",,NZ_CCID,1,CCC#CC,https://pubchem.ncbi.nlm.nih.gov/compound/12310,PubChem,CC#CCC,Train,1,2702,training
-"NZ_CCID:
-3-Buten-1-ol",,627-27-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0B81D269-799D-4FC5-928C-FB69686FD0DE,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C=CCCO,https://pubchem.ncbi.nlm.nih.gov/compound/69389,PubChem,C=CCCO,Train,1,2702,training
-"JP_CHRIP:
-Dimethyl 2,2-dichlorovinyl phosphate; Dichlorvos","JP_CHRIP:
-2,2-Dichlorovinyl dimethyl phosphate
-2,7:3,6-Dimethanonaphth[2,3-b]oxirene, 3,4,5,6,9,9-hexachloro-1a,2,2a,3,6,6a,7,7a-octahydro-, (1aalpha,2beta,2abeta,3alpha,6alpha,6abeta,7beta,7aalpha)-
-DDVP
-Dimethyl 2,2-dichlorovinyl phosphate
-Dimethyl-2,2-dichlorovinyl-phosphate
-Phosphoric acid, 2,2-dichloroethenyl dimethyl ester",62-73-7,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-2001e.html,"JP_CHRIP:
-It was classified in Category 2 because it is reported that severe irritation was seen in a test in which 5-20% aqueous solutions of this substance were applied to the rabbit skin (Initial Risk Assessment Report 86 (NITE, CERI, NEDO, 2008)).",,JP_CHRIP,1,COP(=O)(OC)OC=C(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.352C,J-GLOBAL,COP(=O)(OC)OC=C(Cl)Cl,Train,1,2702,training
-"NZ_CCID:
-Fumaryl chloride",,627-63-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F1B7B8CC-2A1D-4C9C-81A8-55192FD9ED4C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(=C/C(=O)Cl)\C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/5325504,PubChem,O=C(Cl)/C=C/C(=O)Cl,Train,1,2702,training
-"NZ_CCID:
-4-Chloro-2-nitrobenzoic acid",,6280-88-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/162D912F-7202-4FA3-ABB8-212B8701BA9D,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C=C1Cl)[N+](=O)[O-])C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/80475,PubChem,O=C(O)c1ccc(Cl)cc1[N+](=O)[O-],Train,1,2702,training
-"EU_CLP:
-3-chloropropyl chloroformiate",,628-11-5,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C(COC(=O)Cl)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/69399,PubChem,O=C(Cl)OCCCCl,Test,1,2702,training
-"NZ_CCID:
-4-Chlorobutyronitrile",,628-20-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/433BC7C6-7061-43F7-AE4C-55417B962868,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(CC#N)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/12336,PubChem,N#CCCCCl,Train,1,2702,training
-"NZ_CCID:
-2-Ethoxyethyl chloride",,628-34-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AD7F017B-DBFF-4006-A7CF-1986902611A4,"NZ_CCID:
-Skin Irritation
-R38 [MSDS]
-Eye Irritation
-R36 [MSDS]",,NZ_CCID,1,CCOCCCl,https://pubchem.ncbi.nlm.nih.gov/compound/12341,PubChem,CCOCCCl,Train,1,2702,training
-"JP_CHRIP:
-n-Pentyl acetate (n-Amyl acetate)","JP_CHRIP:
-1-Pentyl acetate
-Acetic acid, 1-pentyl ester
-Acetic acid, pentyl ester
-n-Pentyl acetate
-n-Pentyl acetate; n-Amyl acetate",628-63-7,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2122e.html,"JP_CHRIP:
-Although no specific data were available, there is a description that all amyl acetate compounds, including this substance, were irritating to the skin (ACGIH (7th, 2001)), therefore, it was classified in Category 2. In addition, there is a report that no irritation was observed after repeated application of the isomer mixture of this substance to 197 human subjects. Moreover, there is a report that slight irritation was observed after application of an isomer mixture containing this substance to the ears of rabbits, and there is a description that after a 4-hour non-occlusive application of 0.5 mL of the isomer mixture to rabbits, moderate erythema and slight edema were observed and slight desquamation was observed 7 days after application (DFGOT vol. 11 (1996)). Information in ACGIH (7th, 2001) was added and the category was changed.",,JP_CHRIP,1,CCCCCOC(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.224F,J-GLOBAL,CCCCCOC(C)=O,Train,1,2702,training
-"EU_REACH:
-1,4-dimethyl 2,5-dioxocyclohexane-1,4-dicarboxylate",,6289-46-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1907/7/4/2/?documentUUID=48d8556f-08c6-4bcd-9b18-2fe9c5c219e0,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1CC(=O)C(CC1=O)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/94866,PubChem,COC(=O)C1CC(=O)C(C(=O)OC)CC1=O,Train,1,2702,training
-"EU_REACH:
-N-cyclohexyl-N-ethylcarbamoyl chloride",,62899-75-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12832/7/4/2/?documentUUID=1644b99c-95e8-463d-aa24-63fa6bf90526,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(C1CCCCC1)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11332952,PubChem,CCN(C(=O)Cl)C1CCCCC1,Train,1,2702,training
-"NZ_CCID:
-1,6-Dibromohexane",,629-03-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/270AA223-C5EA-469E-AAB2-BAE80F98E5BB,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(CCCBr)CCBr,https://pubchem.ncbi.nlm.nih.gov/compound/12368,PubChem,BrCCCCCCBr,Train,1,2702,training
-"NZ_CCID:
-1-Octyne",,629-05-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BA11C689-B1DC-4B92-AB65-806365FC6825,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCCCCCC#C,https://pubchem.ncbi.nlm.nih.gov/compound/12370,PubChem,C#CCCCCCC,Train,1,2702,training
-"KR_NCIS:
-3-Ethoxypropylamine","KR_NCIS:
-3-Ethoxy-1-propanamine; 3-Ethoxy-1-propylamine; Propanolamine ethyl ether; 3-Ethoxypropanamine; 3-Ethoxypropylamine; 3-Ethoxypropan-1-amine",6291-85-6,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCOCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/22720,PubChem,CCOCCCN,Train,1,2702,training
-"ChemSkin:
-Di-n-propyl disulphide #, ##",,629-19-6,Cat 2,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,CCCSSCCC,https://pubchem.ncbi.nlm.nih.gov/compound/12377,PubChem,CCCSSCCC,Test,1,2702,training
-"EU_REACH:
-1-(4-methoxy-2,3,6-trimethylphenyl)but-3-en-2-one",,62924-31-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23264/7/4/2/?documentUUID=e96ae529-f440-4efc-adca-e7c34fe0d389,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C(=C1/C=C/C(=O)C)C)C)OC,https://pubchem.ncbi.nlm.nih.gov/compound/762510,PubChem,COc1cc(C)c(/C=C/C(C)=O)c(C)c1C,Train,1,2702,training
-"EU_CLP:
-flumetralin (ISO); N-(2-chloro-6-fluorobenzyl)-N-ethyl-α,α,α-trifluoro-2,6-dinitro-p-toluidine",,62924-70-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCN(CC1=C(C=CC=C1Cl)F)C2=C(C=C(C=C2[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/62210,PubChem,CCN(Cc1c(F)cccc1Cl)c1c([N+](=O)[O-])cc(C(F)(F)F)cc1[N+](=O)[O-],Test,1,2702,training
-"NZ_CCID:
-1-Iodooctane",,629-27-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EAEDD862-8DFC-4D08-A57B-DEAC86182E2D,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCCCCCCCI,https://pubchem.ncbi.nlm.nih.gov/compound/12380,PubChem,CCCCCCCCI,Train,1,2702,training
-"EU_REACH:
-1-(octadecyloxy)octadecane",,6297-03-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10944/7/4/2/?documentUUID=daa346a1-fc4a-4c5b-9219-2ba387584a39,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/80526,PubChem,CCCCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCCCC,Train,1,2702,training
-"NZ_CCID:
-1,2-Dibromotetrachloroethane",,630-25-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/934A440E-943A-4094-9C99-9D9B6B424EE1,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(C(Cl)(Cl)Br)(Cl)(Cl)Br,https://pubchem.ncbi.nlm.nih.gov/compound/69426,PubChem,ClC(Cl)(Br)C(Cl)(Cl)Br,Train,1,2702,training
-"EU_REACH:
-(4-ethylphenyl)boronic acid",,63139-21-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24116/7/4/2/?documentUUID=c1b7bee5-568b-4d8d-a8ee-e9dc4a694f8c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,B(C1=CC=C(C=C1)CC)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/2734352,PubChem,CCc1ccc(B(O)O)cc1,Train,1,2702,training
-"EU_REACH:
-2,4,6-tris(propan-2-yl)benzene-1,3-diamine",,6318-09-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11445/7/4/2/?documentUUID=7190deb7-65e4-438c-bc1a-fc1a6151839b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1=CC(=C(C(=C1N)C(C)C)N)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/231851,PubChem,CC(C)c1cc(C(C)C)c(N)c(C(C)C)c1N,Train,1,2702,training
-"EU_CLP:
-2-hydroxymethyl-9-methyl-6-(1-methylethyl)-1,4-dioxaspiro[4.5]decane",,63187-91-7,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC1CCC(C2(C1)OCC(O2)CO)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/162184,PubChem,CC1CCC(C(C)C)C2(C1)OCC(CO)O2,Test,1,2702,training
-"EU_REACH:
-2-amino-4,5-dichlorobenzene-1-sulfonic acid",,6331-96-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1565/7/4/2/?documentUUID=b93489de-5f57-4146-9310-d04819d91c5a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(C(=CC(=C1Cl)Cl)S(=O)(=O)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/235712,PubChem,Nc1cc(Cl)c(Cl)cc1S(=O)(=O)O,Train,1,2702,training
-"NZ_CCID:
-2,3-Dichlorobenzaldehyde",,6334-18-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F5C7D0AE-E629-4FDE-B400-8A6FC7967316,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C(=C1)Cl)Cl)C=O,https://pubchem.ncbi.nlm.nih.gov/compound/35745,PubChem,O=Cc1cccc(Cl)c1Cl,Train,1,2702,training
-"EU_REACH:
-N,N,N',N'-tetrakis(2-hydroxyethyl)hexanediamide",,6334-25-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19275/7/4/2/?documentUUID=2a6bf2b6-956e-4bdb-827e-4d263ee8fae6,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CCC(=O)N(CCO)CCO)CC(=O)N(CCO)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/95283,PubChem,O=C(CCCCC(=O)N(CCO)CCO)N(CCO)CCO,Train,1,2702,training
-"EU_REACH:
-1,3-diethyl 2-({4-[3-ethoxy-2-(ethoxycarbonyl)-3-oxoprop-1-en-1-yl]phenyl}methylidene)propanedioate",,6337-43-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17460/7/4/2/?documentUUID=f06124d6-3e08-4d40-8f37-6503c9044068,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C(=CC1=CC=C(C=C1)C=C(C(=O)OCC)C(=O)OCC)C(=O)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/95823,PubChem,CCOC(=O)C(=Cc1ccc(C=C(C(=O)OCC)C(=O)OCC)cc1)C(=O)OCC,Train,1,2702,training
-"NZ_CCID:
-Pyruvaldehyde 1,1-dimethyl acetal","NZ_CCID:
-pyruvic aldehyde dimethyl acetal",6342-56-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DB4AF03B-8C4A-40F1-860D-C7899F63D78C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(=O)C(OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/80650,PubChem,COC(OC)C(C)=O,Train,1,2702,training
-"AU_HCIS:
-Phenol, 4-methyl-2,6-dinonyl-",,63451-44-5,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5796,,,AU_HCIS,1,CCCCCCCCCC1=CC(=CC(=C1O)CCCCCCCCC)C,https://pubchem.ncbi.nlm.nih.gov/compound/113237,PubChem,CCCCCCCCCc1cc(C)cc(CCCCCCCCC)c1O,Train,1,2702,training
-"NZ_CCID:
-2-Amino-5-chlorobenzoic acid",,635-21-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/894ACB5F-2CEF-46E0-90A0-DD8700E72547,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C=C1Cl)C(=O)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/12476,PubChem,Nc1ccc(Cl)cc1C(=O)O,Train,1,2702,training
-"EU_REACH:
-2-[(2-methoxy-4-nitrophenyl)diazenyl]-N-(2-methoxyphenyl)-3-oxobutanamide",,6358-31-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15183/7/4/2/?documentUUID=18946fb5-4fdb-449f-a96e-2bf7720eeb3d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC=CC=C1OC)N=NC2=C(C=C(C=C2)[N+](=O)[O-])OC,https://pubchem.ncbi.nlm.nih.gov/compound/22829,PubChem,COc1cc([N+](=O)[O-])ccc1N=NC(C(C)=O)C(=O)Nc1ccccc1OC,Train,1,2702,training
-"EU_REACH:
-2,2'-[(3,3'-dichlorobiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis[N-(4-methylphenyl)-3-oxobutanamide]",,6358-37-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13809/7/4/2/?documentUUID=89a1e7e4-dffb-406c-bbe3-85f8ec6390e7,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)NC(=O)C(C(=O)C)N=NC2=C(C=C(C=C2)C3=CC(=C(C=C3)N=NC(C(=O)C)C(=O)NC4=CC=C(C=C4)C)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/110824,PubChem,CC(=O)C(N=Nc1ccc(-c2ccc(N=NC(C(C)=O)C(=O)Nc3ccc(C)cc3)c(Cl)c2)cc1Cl)C(=O)Nc1ccc(C)cc1,Train,1,2702,training
-"EU_REACH:
-4-chloro-2,5-dimethoxyaniline",,6358-64-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1982/7/4/2/?documentUUID=bb847702-328b-4ae5-9c1f-1a3262ec5af0,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC(=C(C=C1N)OC)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/22833,PubChem,COc1cc(Cl)c(OC)cc1N,Train,1,2702,training
-"EU_REACH:
-2-[2-(3,3'-dichloro-4'-{2-[2-oxo-1-(phenylcarbamoyl)propyl]diazen-1-yl}-[1,1'-biphenyl]-4-yl)diazen-1-yl]-3-oxo-N-phenylbutanamide",,6358-85-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15824/7/4/2/?documentUUID=e6862f76-d05d-4361-858b-38996f9c8858,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC=CC=C1)N=NC2=C(C=C(C=C2)C3=CC(=C(C=C3)N=NC(C(=O)C)C(=O)NC4=CC=CC=C4)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/186342,PubChem,CC(=O)C(N=Nc1ccc(-c2ccc(N=NC(C(C)=O)C(=O)Nc3ccccc3)c(Cl)c2)cc1Cl)C(=O)Nc1ccccc1,Train,1,2702,training
-"EU_REACH:
-diethyl 4,4'-[(3,3'-dichlorobiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis(5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylate)",,6358-87-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11113/7/4/2/?documentUUID=11653206-0d0c-4c50-ac7f-50e29872aec0,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1=NN(C(=O)C1N=NC2=C(C=C(C=C2)C3=CC(=C(C=C3)N=NC4C(=NN(C4=O)C5=CC=CC=C5)C(=O)OCC)Cl)Cl)C6=CC=CC=C6,https://pubchem.ncbi.nlm.nih.gov/compound/95076,PubChem,CCOC(=O)C1=NN(c2ccccc2)C(=O)C1N=Nc1ccc(-c2ccc(N=NC3C(=O)N(c4ccccc4)N=C3C(=O)OCC)c(Cl)c2)cc1Cl,Train,1,2702,training
-"NZ_CCID:
-Pyridine-3-sulphonic acid","NZ_CCID:
-3-pyridinesulfonic acid",636-73-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6644E58D-3F6F-4786-A053-901311E7AB84,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CN=C1)S(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/69468,PubChem,O=S(=O)(O)c1cccnc1,Train,1,2702,training
-"EU_REACH:
-1-(4-methoxyphenyl)-2-[(3-methoxyphenyl)sulfanyl]ethan-1-one",,63675-73-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8584/7/4/2/?documentUUID=46cf7090-9525-4489-95a3-e6b704f66fb3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC=C(C=C1)C(=O)CSC2=CC=CC(=C2)OC,https://pubchem.ncbi.nlm.nih.gov/compound/10108176,PubChem,COc1ccc(C(=O)CSc2cccc(OC)c2)cc1,Train,1,2702,training
-"NZ_CCID:
-2-Methoxy-5-nitrophenol",,636-93-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C998E1A0-8095-4ABE-B523-88946D51ACDE,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,COC1=C(C=C(C=C1)[N+](=O)[O-])O,https://pubchem.ncbi.nlm.nih.gov/compound/69471,PubChem,COc1ccc([N+](=O)[O-])cc1O,Train,1,2702,training
-"NZ_CCID:
-Sulphanilamide",,63-74-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1AAEE578-B441-4947-96E7-3487A73DCBB3,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [MSDS]
-[http://physchem.ox.ac.uk/MSDS/SU/sulfanilamide.html]
-Eye Irritation
-R PHRASE: R 36 [MSDS]
-[http://physchem.ox.ac.uk/MSDS/SU/sulfanilamide.html]",,NZ_CCID,1,C1=CC(=CC=C1N)S(=O)(=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/5333,PubChem,Nc1ccc(S(N)(=O)=O)cc1,Train,1,2702,training
-"NZ_CCID:
-Phenylacetylenecarboxylic acid","NZ_CCID:
-phenylpropiolic acid",637-44-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CCDBC174-B1BF-4B83-BE52-B048E7525E93,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)C#CC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/69475,PubChem,O=C(O)C#Cc1ccccc1,Train,1,2702,training
-"NZ_CCID:
-3-Phenylpropyl bromide","NZ_CCID:
-1-bromo-3-phenylpropane",637-59-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/771D26AD-9741-4CA0-A4DC-16A3E5C12D99,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)CCCBr,https://pubchem.ncbi.nlm.nih.gov/compound/12503,PubChem,BrCCCc1ccccc1,Train,1,2702,training
-"KR_NCIS:
-4-Mercaptophenol",,637-89-8,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C1=CC(=CC=C1O)S,https://pubchem.ncbi.nlm.nih.gov/compound/240147,PubChem,Oc1ccc(S)cc1,Train,1,2702,training
-"JP_CHRIP:
-Propane, 2-ethoxy-2-methyl-","JP_CHRIP:
-2-Ethoxy-2-methylpropane
-ETBE
-Ethyl 1,1-dimethylethyl ether",637-92-3,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0666e.html,"JP_CHRIP:
-Based on the Draize score of P.I.I.3.03 (Moderate Irritant) in test on rabbits (ACGIH (2002)), it was classified as Category 2.",,JP_CHRIP,1,CCOC(C)(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J45.669A,J-GLOBAL,CCOC(C)(C)C,Train,1,2702,training
-"NZ_CCID:
-Ethyl 4-chloroacetoacetate",,638-07-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/47ACF8C8-D7FD-41C6-BD72-8049A3E848A2,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCOC(=O)CC(=O)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/69484,PubChem,CCOC(=O)CC(=O)CCl,Train,1,2702,training
-"JP_CHRIP:
-phenylphosphine","JP_CHRIP:
-Phosphaniline",638-21-1,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0899e.html,"JP_CHRIP:
-There was no concrete case report. But it was set as Category 2 from description that the skin was stimulated (ICSC (2001), HSDB (2005), and HSFS (2001)).",,JP_CHRIP,1,Pc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.630F,J-GLOBAL,Pc1ccccc1,Train,1,2702,training
-"EU_REACH:
-pentanoyl chloride
-
-KR_NCIS:
-Pentanoyl chloride
-
-NZ_CCID:
-Pentanoyl chloride","NZ_CCID:
-valeryl chloride",638-29-9,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13405/7/4/2/?documentUUID=581a0611-c4a1-417c-ab5b-58a76304d0da
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/02DC9D69-4BF4-4DD2-8A50-1AFA33594879","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",Provided,"EU_REACH, KR_NCIS, NZ_CCID",3,CCCCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/61186,PubChem,CCCCC(=O)Cl,Train,1,2702,training
-"EU_REACH:
-3,3',5,5'-tetra-tert-butyl-[1,1'-biphenyl]-2,2'-diol",,6390-69-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8588/7/4/2/?documentUUID=847acff3-7edb-47bc-81d1-6a072c21791f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1=CC(=C(C(=C1)C(C)(C)C)O)C2=C(C(=CC(=C2)C(C)(C)C)C(C)(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/80808,PubChem,CC(C)(C)c1cc(-c2cc(C(C)(C)C)cc(C(C)(C)C)c2O)c(O)c(C(C)(C)C)c1,Train,1,2702,training
-"JP_CHRIP:
-beta-Phenylethylamine; Phenethylamine
-
-NZ_CCID:
-2-Phenylethylamine
-
-US_HSDB:
-2-Phenylethylamine","JP_CHRIP:
-2-phenylethylamine
-
-NZ_CCID:
-phenethylamine",64-04-0,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0169e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/73A60AF8-AF34-4B5A-9AEA-2FA6EDD93455
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/3526","JP_CHRIP:
-The substance was classified as Category 1 based on physicochemical property of pH = 11.5 (GESTIS (Access on Oct. 2010)). As relevant notes, there was the information that the substance caused skin irritation in the human exposure study (HSDB (2003)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,NCCc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.833J,J-GLOBAL,NCCc1ccccc1,Train,1,2702,training
-"EU_REACH:
-1,4-diamino-2,3-diphenoxyanthraquinone",,6408-72-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23201/7/4/2/?documentUUID=57e87450-461c-4dc0-ab9e-b0d3750ac9a4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)OC2=C(C3=C(C(=C2OC4=CC=CC=C4)N)C(=O)C5=CC=CC=C5C3=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/80839,PubChem,Nc1c(Oc2ccccc2)c(Oc2ccccc2)c(N)c2c1C(=O)c1ccccc1C2=O,Train,1,2702,training
-"EU_REACH:
-4-[(2,5-dichlorophenyl)azo]-3-hydroxy-N-(2-methoxyphenyl)naphthalene-2-carboxamide",,6410-38-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21751/7/4/2/?documentUUID=2ee44ede-7d8b-40aa-8170-5c2ef3ad7a4e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC=CC=C1NC(=O)C2=CC3=CC=CC=C3C(=C2O)N=NC4=C(C=CC(=C4)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/22920,PubChem,COc1ccccc1NC(=O)c1cc2ccccc2c(N=Nc2cc(Cl)ccc2Cl)c1O,Train,1,2702,training
-"NZ_CCID:
-3-Nitrophthalic anhydride",,641-70-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/216121B0-3436-4FAB-9660-E142A53EE84C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC2=C(C(=C1)[N+](=O)[O-])C(=O)OC2=O,https://pubchem.ncbi.nlm.nih.gov/compound/21631,PubChem,O=C1OC(=O)c2c1cccc2[N+](=O)[O-],Train,1,2702,training
-"JP_CHRIP:
-Ethanol","JP_CHRIP:
-Ethanol in alcoholic beverages
-Ethyl alcohol",64-17-5,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-2007e.html,"JP_CHRIP:
-It was classified as ""Not classified"" because it is assessed in SIDS (2005) that in a 4-hour exposure test with rabbits (OECD TG 404), the average scores at 1 and 24 hours after application were 1.0 for erythema, the average scores at the other time points were all 0.0 for erythema and edema, and it was not irritating.",Provided,JP_CHRIP,1,CCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.930E,J-GLOBAL,CCO,Train,1,2702,training
-"AU_HCIS:
-Formic acid … %
-
-JP_CHRIP:
-Formic acid
-
-KR_NCIS:
-Formic acid
-
-NZ_CCID:
-Formic acid with more than 85% acid by mass","AU_HCIS:
-Methanoic acid
-Hydrogen carboxylic acid
-Aminic acid
-Acidium formicum
-Myrmicyl
-
-JP_CHRIP:
-Aminic acid
-Formylic acid
-Hydrogen carboxylic acid
-Methanoic acid
-
-NZ_CCID:
-Aminic acid, Formic acid, Formylic acid, Hydrogen carboxylic acid, Methanoic acid, Myrmicyl",64-18-6,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=2182
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2029e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/578E110A-4904-4695-9750-4B088906FE43","JP_CHRIP:
-There is a report that corrosivity and strong irritation were observed in a skin irritation test with rabbits (DFGOT vol. 19 (2003), IUCLID (2000)), and there are many descriptions that it was corrosive to human skin (SIDS (2011), NTP TR19 (1992), OEL Documentations (Japan Society For Occupational Health (JSOH), 1978), Environmental Risk Assessment for Chemical Substances Vol.6, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2008)), therefore, it was classified in Category 1. Besides, this substance has pH=2.2 (at 10 g/L, 20 deg C) (IUCLID (2000)), and it was classified in ""C: R35"" in the EU DSD classification, and in ""H314 Skin Corr. 1A"" in the EU CLP classification.
-
-NZ_CCID:
-Skin Irritation
-R-PHRASE: R 35 Causes severe burns. [iuclid 2000]
-REMARK: UN class 8 PG II
-Eye Irritation
-R-PHRASE: R 35 Causes severe burns. [iuclid 2000]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID",4,OC=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.402H,J-GLOBAL,O=CO,Train,1,2702,training
-"NZ_CCID:
-Aminotri(methylenephosphonic acid)",,6419-19-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2CD6ECCB-4E14-462D-8E66-DB8287E34BBE,"NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit (New Zealand white rabbits)
-RESULT: No oedema, mild erythema. Primary irritation index (PII) = 0.4.
-REFERENCE SOURCE: HERA Human and Environmental risk Assessment on ingredients of European household cleaning products Phosphonates report http://www.heraproject.com/files/30-F-04-%20HERA%20Phosphonates%20Full%20web%20wd.pdf
-RELIABILITY (KLIMISCH SCORE):
-Eye Irritation
-SPECIES:Rabbit
-RESULT: Observations included oedema, lid closure, copious discharge, moderate redness of the conjunctivae and mild corneal cloudiness immediately after instillation. After 24hrs and rinsing of the eyes, observations included lid closure and iris congestion. Suggests
-REFERENCE SOURCE: HERA Human and Environmental risk Assessment on ingredients of European household cleaning products Phosphonates report http://www.heraproject.com/files/30-F-04-%20HERA%20Phosphonates%20Full%20web%20wd.pdf",,NZ_CCID,1,C(N(CP(=O)(O)O)CP(=O)(O)O)P(=O)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/16698,PubChem,O=P(O)(O)CN(CP(=O)(O)O)CP(=O)(O)O,Train,1,2702,training
-"JP_CHRIP:
-Acetic acid
-
-NZ_CCID:
-Acetic acid >80% aqueous solution
-
-US_HSDB:
-ACETIC ACID","JP_CHRIP:
-acetic acid, of a concentration of more than 10 per cent, by weight, of acetic acid
-Ethanoic acid
-Ethylic acid
-Glacial acetic acid
-Methanecarboxylic acid
-
-NZ_CCID:
-Ethanoic acid, Ethylic acid, Glacial acetic acid, Methane carboxylic acid, Vinegar acid",64-19-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2026e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/584EE2CE-4D24-4124-80E2-C933677851B6
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/40","JP_CHRIP:
-In tests with rabbits and guinea pigs (PATTY (5th, 2001), ACGIH (2004)), the degree of irritation depended on the application concentrations and exposure periods. Concentrations from 50 - 80% produced severe burns and eschar formation. The substance is classified into C; R35 in EU classification. Based on these data, the substance was classified into Category 1. In addition, the pH is 2.4 (1.0M) (Merck (14th, 2006)).
-
-NZ_CCID:
-Skin Irritation
-UN CLASS: 8 PG II
-Eye Irritation
-R-PHRASE: R 35 Causes severe burns. [IUCLID 2000]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,CC(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.355H,J-GLOBAL,CC(=O)O,Train,1,2702,training
-"EU_REACH:
-1,1'-(4-methyl-1,3-phenylene)bis-1H-pyrrole-2,5-dione",,6422-83-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24680/7/4/2/?documentUUID=3b7daa9c-d65e-4a35-beda-248660b53e28,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)N2C(=O)C=CC2=O)N3C(=O)C=CC3=O,https://pubchem.ncbi.nlm.nih.gov/compound/80893,PubChem,Cc1ccc(N2C(=O)C=CC2=O)cc1N1C(=O)C=CC1=O,Train,1,2702,training
-"EU_REACH:
-4-{2-[2-(morpholin-4-yl)ethoxy]ethyl}morpholine",,6425-39-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13298/7/4/2/?documentUUID=803df8c4-eddb-4170-83b5-f0ff3a63888b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1COCCN1CCOCCN2CCOCC2,https://pubchem.ncbi.nlm.nih.gov/compound/80900,PubChem,C1CN(CCOCCN2CCOCC2)CCO1,Train,1,2702,training
-"EU_REACH:
-N-(2-hydroxyethyl)-N-[2-[(1-oxooctyl)amino]ethyl]-β-alanine",,64265-45-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24845/7/4/2/?documentUUID=c87fa00f-e8b9-4df7-a23a-3e29b6594b70,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCC(=O)NCCN(CCC(=O)O)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/116569,PubChem,CCCCCCCC(=O)NCCN(CCO)CCC(=O)O,Train,1,2702,training
-"EU_REACH:
-3-(decylalkyl-(branched)oxy)-propiononitrile",,64354-92-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5608/7/4/2/?documentUUID=8fd65cbb-9be6-4908-adcf-7e8be2f5ae6a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCCCOCCC#N,https://pubchem.ncbi.nlm.nih.gov/compound/110608,PubChem,CC(C)CCCCCCCOCCC#N,Train,1,2702,training
-"AU_HCIS:
-3(2H)-Isothiazolone, 4,5-dichloro-2-octyl-
-
-JP_CHRIP:
-4,5-dichloro-2-octyl-2H-isothiazol-3-one
-
-KR_NCIS:
-4,5-Dichloro-2-N-octyl-4-isothiazolin-3-one
-
-NZ_CCID:
-3(2H)-Isothiazolone, 4,5-dichloro-2-octyl-
-
-US_HSDB:
-4,5-Dichloro-2-octyl-3-isothiazolone","JP_CHRIP:
-4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one
-
-NZ_CCID:
-4,5-Dichloro-2-octyl-2H-isothiazol-3-one, 4,5-Dichloro-2-n-octyl-3(2H)-isothiazolone, 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one, 4,5-Dichloro-2-octyl-3(2H)-isothiazolone, DCOIT",64359-81-5,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6597
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0014e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F0A9E98B-3BCA-461E-9C19-DD0A189DDDF1
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8454","JP_CHRIP:
-[Rationale for the Classification]
-It was classified in Category 1 from (1) - (4).
-
-[Evidence Data]
-(1) It is reported that in a human repeated insult patch test (HRIPT) in 34 persons, barely perceptible to moderate irritation reactions were observed in 16 during the induction phase with a 0.025% solution of this substance (ECHA RAC Opinion (2018)).
-(2) In a skin irritation test with rabbits (n = 3) (OECD TG 404, 4-hour application, 14-day observation), all the animals showed slight to severe erythema/edema throughout 14 days, and effects were irreversible. Destruction of all layers of the skin was estimated after 4-hour application of this substance (erythema/eschar score: 3.3/2/1.7, edema score: 2.7/2/2) (ECHA RAC Opinion (2018), AICIS (formerly, NICNAS IMAP) (2018)).
-(3) In a skin irritation test with a rabbit (n = 1) (OECD TG 404, 4-hour application, 14-day observation), the mean score at 24/48/72 hours was 4.0 for erythema and 3.3 for edema. Skin irritation indicative of corrosivity (concave eschar) was seen within 48 hours, and corrosive findings (ulcer /erosion) were observed after 14 days. Skin reactions were considered as corrosive (ECHA RAC Opinion (2018), AICIS (formerly, NICNAS IMAP) (2018)).
-(4) In a skin irritation test with rabbits (n = 6) (OECD TG 404, 4-hour application, 14-day observation), moderate to severe erythema/edema was seen after 1 hour. The mean score at 24/48/72 hours was 4.0 for erythema and 3.9 for edema. At 14 days, there was no edema, but slight to severe erythema, eschar, areas without hair growth, and whitened areas, and scar formation was observed in 5 of 6 animals. Skin reactions were considered as corrosive (ECHA RAC Opinion (2018), AICIS (formerly, NICNAS IMAP) (2018)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Corrosive
-REFERENCE SOURCE: Rohm and Haas product MSDS for Sea nine - 211.
-REMARK: Sea nine 211 comprises >30% 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one, >68% o-xylene and 2% impurities
-.
-Eye Irritation
-SPECIES:
-RESULT: RH-287 is considered corrosive to the skin and eyes.
-REFERENCE SOURCE: EPA Federal Register http://pmep.cce.cornell.edu/profiles/miscpesticides/alphaalkyl-metaldehyde/cas64359-81-5/cas64359-81-5_pet_998.html
-REMARK: RH-287 = 4,5-dichloro-2-n-octyl-3(2H)-isothiazolone, CASRN 64359-81- 5.",Provided,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,CCCCCCCCn1sc(Cl)c(Cl)c1=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J286.903I,J-GLOBAL,CCCCCCCCn1sc(Cl)c(Cl)c1=O,Train,1,2702,training
-"EU_REACH:
-phthalaldehyde
-
-JP_CHRIP:
-Phthalaldehyde
-
-NZ_CCID:
-Phthaldialdehyde
-
-US_HSDB:
-o-Phthalaldehyde","NZ_CCID:
-o-phthalaldehyde",643-79-8,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27723/7/4/2/?documentUUID=58a3c705-4301-4b4c-8a2e-22a9e8b28db8
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-0012e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F326FCEF-1624-4060-9893-13E826AA995E
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8456","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-[Rationale for the Classification]
-Based on (1), it was classified in Category 1.
-
-[Evidence Data]
-(1) In a skin irritation test (4 hour-semi-occlusive application) with rabbits in compliance with OECD TG 404, the mean scores for erythema and edema at 24/48/72 hours were 1.8 and 2.9, respectively. Since eschar and scars were notable 14 days post application, it was judged to be corrosive (REACH registration dossier (Access on July 2019)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",Provided,"EU_REACH, JP_CHRIP, NZ_CCID, US_HSDB",4,O=Cc1ccccc1C=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J45.641A,J-GLOBAL,O=Cc1ccccc1C=O,Train,1,2702,training
-"JP_CHRIP:
-Phenyldichlorophosphine
-
-KR_NCIS:
-Dichloro(phenyl)phosphine
-
-NZ_CCID:
-Dichlorophenylphosphine","JP_CHRIP:
-Benzenephosphonous dichloride
-dichlorophenylphosphine",644-97-3,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0107e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/225BB3F0-ED51-4763-9E3D-07BEB4468DCE","JP_CHRIP:
-It was classified in Category 1 because it is described that it is a high irritant to the skin, eye, and mucous membranes and is highly capable of causing deaths or permanent injury due to exposure of normal use in humans (HSDB (2003)), and it is also described that it is corrosive to the skin and tissue (HSDB (2003)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,ClP(Cl)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.568G,J-GLOBAL,ClP(Cl)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-3-Phenylpropionyl chloride",,645-45-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B494127C-6202-4C08-9F2F-BEDAA2285D31,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)CCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/64801,PubChem,O=C(Cl)CCc1ccccc1,Train,1,2702,training
-"NZ_CCID:
-4-Methyl pentanoic acid","NZ_CCID:
-4-methylvaleric acid",646-07-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E102356D-9F8A-4C2B-B45F-9944A448324C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)CCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/12587,PubChem,CC(C)CCC(=O)O,Train,1,2702,training
-"NZ_CCID:
-1,7-Diaminoheptane",,646-19-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/29F505D4-ECEC-4EA2-B32C-7F63D54CC61B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(CCCN)CCCN,https://pubchem.ncbi.nlm.nih.gov/compound/69533,PubChem,NCCCCCCCN,Train,1,2702,training
-"NZ_CCID:
-1,9-Diaminononane",,646-24-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F9B704EA-DB77-4DA7-A5A7-371B84963EDE,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(CCCCN)CCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/69534,PubChem,NCCCCCCCCCN,Train,1,2702,training
-"EU_REACH:
-N-(dodecylphenyl)naphthalen-1-amine",,64654-05-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29609/7/4/2/?documentUUID=7a5e635c-a4cd-4272-acfc-94d1aad845c4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCC1=CC=CC=C1NC2=CC=CC3=CC=CC=C32,https://pubchem.ncbi.nlm.nih.gov/compound/116650,PubChem,CCCCCCCCCCCCc1ccccc1Nc1cccc2ccccc12,Train,1,2702,training
-"AU_HCIS:
-diethyl sulphate
-
-JP_CHRIP:
-Diethyl sulfate
-
-KR_NCIS:
-Diethyl sulfate
-
-NZ_CCID:
-Diethyl sulphate","AU_HCIS:
-diethyl sulfate
-
-JP_CHRIP:
-Diethyl sulfate
-DES
-diethyl sulphate
-Sulfuric acid diethyl ester
-Sulfuric acid, diethyl ester
-
-KR_NCIS:
-Sulfuric acid, diethyl ester; Diethylsulfate
-
-NZ_CCID:
-Diethylsulfate, Ethyl sulfate, Sulfuric acid diethyl ester, Sulfuric acid, diethyl ester",64-67-5,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1341
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0992e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3C7A3911-6A76-4272-BD6A-100FD48BEE17","JP_CHRIP:
-From description that the necrosis arose by application on the skin of the rabbit (CERI Hazard Data (1996) and DFGOT (vol.20, 2003)), it was judged that there was caustic and it was set as Category 1A-1C.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID",4,CCOS(=O)(=O)OCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.811H,J-GLOBAL,CCOS(=O)(=O)OCC,Train,1,2702,training
-"JP_CHRIP:
-iodoacetic acid
-
-NZ_CCID:
-Iodoacetic acid
-
-US_HSDB:
-Iodoacetic acid",,64-69-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0069e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/124018A4-303E-4677-ADD2-7DFAA28A8A39
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/4008","JP_CHRIP:
-Two human cases of severe and bullous contact dermatitis have been reported (HSDB (2003)), and it is rated R35 in EU classification (EU Annex I (assessed on July, 2008)) and its pH = 1.4 (20degC, 50 g/L) (GESTIS (accessed July 2008)). Thus, the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 35 [Company Data]
-Eye Irritation
-R PHRASE: R 35 [Company Data]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,OC(=O)CI,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.405B,J-GLOBAL,O=C(O)CI,Train,1,2702,training
-"NZ_CCID:
-Tolbutamide",,64-77-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DE7B44E4-83F8-441D-9A0E-52BD41A12CDC,"NZ_CCID:
-Skin Irritation
-REMARK: Confidential information supplied by registrant
-Eye Irritation
-REMARK: Confidential information supplied by registrant",,NZ_CCID,1,CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C,https://pubchem.ncbi.nlm.nih.gov/compound/5505,PubChem,CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1,Train,1,2702,training
-"EU_REACH:
-2,2'-[(3,3'-dimethoxybiphenyl-4,4'-diyl)didiazene-2,1-diyl]bis(3-oxo-N-phenylbutanamide)",,6505-28-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16885/7/4/2/?documentUUID=6b3d00ed-6ab5-4100-b222-c2ce91c018b1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC=CC=C1)N=NC2=C(C=C(C=C2)C3=CC(=C(C=C3)N=NC(C(=O)C)C(=O)NC4=CC=CC=C4)OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/110869,PubChem,COc1cc(-c2ccc(N=NC(C(C)=O)C(=O)Nc3ccccc3)c(OC)c2)ccc1N=NC(C(C)=O)C(=O)Nc1ccccc1,Train,1,2702,training
-"EU_CLP:
-2,3,5,6-tetrafluorobenzoic acid",,652-18-6,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=C(C(=C(C(=C1F)F)C(=O)O)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/567533,PubChem,O=C(O)c1c(F)c(F)cc(F)c1F,Test,1,2702,training
-"EU_REACH:
-3-hydroxy-N-(2-methylphenyl)-4-[(2,4,5-trichlorophenyl)diazenyl]-2-naphthamide",,6535-46-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14453/7/4/2/?documentUUID=26b187c5-65c1-401b-a17e-cdd69a6c1518,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=CC=C1NC(=O)C2=CC3=CC=CC=C3C(=C2O)N=NC4=CC(=C(C=C4Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/23034,PubChem,Cc1ccccc1NC(=O)c1cc2ccccc2c(N=Nc2cc(Cl)c(Cl)cc2Cl)c1O,Train,1,2702,training
-"EU_REACH:
-(1r,1's,4r,4'r)-4'-propyl-[1,1'-bi(cyclohexane)]-4-carboxylic acid",,65355-32-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26387/7/4/2/?documentUUID=658e847d-2583-4d44-ba1c-e489d852a25c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2CCC(CC2)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/793726,PubChem,CCCC1CCC(C2CCC(C(=O)O)CC2)CC1,Train,1,2702,training
-"KR_NCIS:
-2-Amino-5-hydroxy-1,7-naphthalenedisulphonic acid",,6535-70-2,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C1=CC(=C(C2=C1C(=CC(=C2)S(=O)(=O)O)O)S(=O)(=O)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/81024,PubChem,Nc1ccc2c(O)cc(S(=O)(=O)O)cc2c1S(=O)(=O)O,Train,1,2702,training
-"EU_REACH:
-(E)-4-decenal",,65405-70-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17668/7/4/2/?documentUUID=323426b2-c9d3-4178-abad-14388c0cd2f8,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC/C=C/CCC=O,https://pubchem.ncbi.nlm.nih.gov/compound/5702654,PubChem,CCCCC/C=C/CCC=O,Test,1,2702,training
-"EU_REACH:
-2-methyl-4-(2,6,6-trimethylcyclohex-2-en-1-yl)butanal",,65405-84-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10563/7/4/2/?documentUUID=d0af65ba-5533-4852-87ac-feb2c803c3eb,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CCC=O)C1C(=CCCC1(C)C)C,https://cactus.nci.nih.gov/chemical/structure/65405-84-7/smiles,CACTUS,CC1=CCCC(C)(C)C1C(C)CCC=O,Train,1,2702,training
-"EU_REACH:
-6-sec-butylquinoline",,65442-31-1,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27814/7/4/2/?documentUUID=697d371d-e0cc-42e2-933e-3d008f1c2444,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)C1=CC2=C(C=C1)N=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/103401,PubChem,CCC(C)c1ccc2ncccc2c1,Train,1,2702,training
-"NZ_CCID:
-2,4,6-Triisopropylbenzenesulphonyl chloride",,6553-96-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/035578E0-1BC7-4B67-9513-CD7E4AE0FACA,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)C1=CC(=C(C(=C1)C(C)C)S(=O)(=O)Cl)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/81042,PubChem,CC(C)c1cc(C(C)C)c(S(=O)(=O)Cl)c(C(C)C)c1,Train,1,2702,training
-"EU_REACH:
-3,4-dichlorobenzonitrile",,6574-99-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11998/7/4/2/?documentUUID=7a6880ae-422e-4d9a-a135-e6d271501960,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C=C1C#N)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/81051,PubChem,N#Cc1ccc(Cl)c(Cl)c1,Train,1,2702,training
-"EU_CLP:
-2-chloro-3-trifluoromethylpyridine",,65753-47-1,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC(=C(N=C1)Cl)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/589833,PubChem,FC(F)(F)c1cccnc1Cl,Test,1,2702,training
-"EU_REACH:
-Dimethoxy-methyl-[3-(oxiran-2-ylmethoxy)propyl]silane",,65799-47-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25241/7/4/2/?documentUUID=119db97d-d3ac-47cb-8ea8-533f47c3dfa6,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CO[Si](C)(CCCOCC1CO1)OC,https://pubchem.ncbi.nlm.nih.gov/compound/2759249,PubChem,CO[Si](C)(CCCOCC1CO1)OC,Train,1,2702,training
-"AU_HCIS:
-Benzoic acid",,65-85-0,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=433,,,AU_HCIS,1,C1=CC=C(C=C1)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/243,PubChem,O=C(O)c1ccccc1,Train,1,2702,training
-"EU_REACH:
-2-ethyl-2-(((3,5,5-trimethylhexanoyl)oxy)methyl)propane-1,3-diyl bis(3,5,5-trimethylhexanoate)",,65870-94-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5388/7/4/2/?documentUUID=7c3a05d6-9c84-408f-bf81-cabb24589733,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(COC(=O)CC(C)CC(C)(C)C)(COC(=O)CC(C)CC(C)(C)C)COC(=O)CC(C)CC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/54263204,PubChem,CCC(COC(=O)CC(C)CC(C)(C)C)(COC(=O)CC(C)CC(C)(C)C)COC(=O)CC(C)CC(C)(C)C,Train,1,2702,training
-"EU_REACH:
-butyl 2-cyanoprop-2-enoate",,6606-65-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11564/7/4/2/?documentUUID=e025a324-6e92-4598-8805-833941225731,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOC(=O)C(=C)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/23087,PubChem,C=C(C#N)C(=O)OCCCC,Train,1,2702,training
-"EU_REACH:
-1,4,7-Trioxacyclotridecane-8,13-dione",,6607-34-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6710/7/4/2/?documentUUID=7d2d6a1d-0dc0-4826-af2f-e07cef4b5254,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CCC(=O)OCCOCCOC(=O)C1,https://pubchem.ncbi.nlm.nih.gov/compound/81082,PubChem,O=C1CCCCC(=O)OCCOCCO1,Train,1,2702,training
-"EU_REACH:
-455-890-7",,6607-41-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15687/7/4/2/?documentUUID=3f580708-c9ff-4d52-99ef-a8a440fe22f0,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3C2(C4=CC=C(C=C4)O)C5=CC=C(C=C5)O,https://pubchem.ncbi.nlm.nih.gov/compound/2832097,PubChem,O=C1c2ccccc2C(c2ccc(O)cc2)(c2ccc(O)cc2)N1c1ccccc1,Train,1,2702,training
-"EU_REACH:
-2-ethoxybenzonitrile",,6609-57-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30034/7/4/2/?documentUUID=17ee1751-4ecc-437f-9867-828f94051d63,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=CC=CC=C1C#N,https://pubchem.ncbi.nlm.nih.gov/compound/576922,PubChem,CCOc1ccccc1C#N,Train,1,2702,training
-"EU_CLP:
-3,5-dimethylbenzoyl chloride",,6613-44-1,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC1=CC(=CC(=C1)C(=O)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/81088,PubChem,Cc1cc(C)cc(C(=O)Cl)c1,Test,1,2702,training
-"AU_HCIS:
-3,6,9,12,15,18-Hexaoxaeicosan-1-ol, 20-(dinonylphenoxy)-, dihydrogen phosphate",,66172-78-9,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6690,,,AU_HCIS,1,CCCCCCCCCC1=C(C(=CC=C1)CCCCCCCCC)OCCOCCOCCOCCOCCOCCOCCOP(=O)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/105314,PubChem,CCCCCCCCCc1cccc(CCCCCCCCC)c1OCCOCCOCCOCCOCCOCCOCCOP(=O)(O)O,Train,1,2702,training
-"EU_REACH:
-N2-cyclopropyl-1,3,5-triazine-2,4,6-triamine",,66215-27-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33022/7/4/2/?documentUUID=727e271e-befd-4754-9bbf-19ae5f5ba261,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC1NC2=NC(=NC(=N2)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/47866,PubChem,Nc1nc(N)nc(NC2CC2)n1,Train,1,2702,training
-"NZ_CCID:
-6-Bromohexanonitrile",,6621-59-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/ECAB08B6-11C9-4B91-853A-C1CFA8D46F6A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(CCC#N)CCBr,https://pubchem.ncbi.nlm.nih.gov/compound/81093,PubChem,N#CCCCCCBr,Train,1,2702,training
-"JP_CHRIP:
-Hexanal
-
-NZ_CCID:
-Hexanal","JP_CHRIP:
-hexanal",66-25-1,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0083e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6BFCCC50-60CE-4765-A052-E27DC08AB677","JP_CHRIP:
-Based on reports that the substance is ""irritant"" (PATTY (5th, 2001)) and ""irritating"" for the skin (HSDB (2003)), the substance was classified into Category 2. As relevant information, there is a result of ""mild"" irritating in a standard Draize test where 500 mg was applied to the skin of rabbits for 24-hour (RTECS (2008)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CCCCCC=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.409E,J-GLOBAL,CCCCCC=O,Train,1,2702,training
-"NZ_CCID:
-2-Bromobenzaldehyde",,6630-33-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/699B1B54-964B-49A7-B34A-3C6A0E70FDD6,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)C=O)Br,https://pubchem.ncbi.nlm.nih.gov/compound/81129,PubChem,O=Cc1ccccc1Br,Train,1,2702,training
-"EU_REACH:
-N-[2-[(2-chloro-4,6-dinitrophenyl)azo]-5-(diethylamino)phenyl]acetamide",,66557-45-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20015/7/4/2/?documentUUID=013168fb-5a20-47b9-9d79-5d8515924f69,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(CC)C1=CC(=C(C=C1)N=NC2=C(C=C(C=C2Cl)[N+](=O)[O-])[N+](=O)[O-])NC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/3017688,PubChem,CCN(CC)c1ccc(N=Nc2c(Cl)cc([N+](=O)[O-])cc2[N+](=O)[O-])c(NC(C)=O)c1,Train,1,2702,training
-"EU_REACH:
-isopropyl 2-methylbutyrate",,66576-71-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23871/7/4/2/?documentUUID=3589c168-755f-4b1a-977b-e1daa2b2722b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)C(=O)OC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/522214,PubChem,CCC(C)C(=O)OC(C)C,Train,1,2702,training
-"EU_REACH:
-5-amino-6-methyl-2,3-dihydro-1H-1,3-benzodiazol-2-one",,67014-36-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10453/7/4/2/?documentUUID=d41af473-2546-49ad-a0d1-9506ddd64e80,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC2=C(C=C1N)NC(=O)N2,https://pubchem.ncbi.nlm.nih.gov/compound/352271,PubChem,Cc1cc2[nH]c(=O)[nH]c2cc1N,Train,1,2702,training
-"EU_REACH:
-2-chlorophenyl cyclopentyl ketone",,6740-85-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24360/7/4/2/?documentUUID=f7aa4481-c327-456b-9f65-a3d1681d0899,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CCC(C1)C(=O)C2=CC=CC=C2Cl,https://pubchem.ncbi.nlm.nih.gov/compound/81223,PubChem,O=C(c1ccccc1Cl)C1CCCC1,Train,1,2702,training
-"NZ_CCID:
-Pentetic acid","NZ_CCID:
-Glycine, N,N-bis[2-[bis(carboxymethyl)amino]ethyl]-",67-43-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FC15A593-76A6-43B9-A356-DA202FD4278F,"NZ_CCID:
-Skin Irritation
-REMARK: Classification based on company data.
-Eye Irritation
-REMARK: Classification based on company data.",,NZ_CCID,1,C(CN(CC(=O)O)CC(=O)O)N(CCN(CC(=O)O)CC(=O)O)CC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/3053,PubChem,O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O,Train,1,2702,training
-"JP_CHRIP:
-4-Methylideneoxetan-2-one","JP_CHRIP:
-3-butene-3-olide
-3-Buteno-beta-lactone
-4-Methylene-2-oxetanone
-Acetyl ketene
-but-3-en-3-olide
-Diketene",674-82-8,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-meti-0064e.html,"JP_CHRIP:
-Since there is a description, ""4.9 Draize units"" (IUCLID (2000)) and the study of a cited literature (Ind. Hyg. Found. Am. Chem. Toxicol. Ser. Bull. 6 (1967)) showed the rsult corresponding to ""moderate irritation"", it was classified in Category 2. In addition, there are descriptions, ""moderate""RTECS (2006) in the 24 hour Draize test with rabbits and ""mild"" in the study with rabbits. Moreover, there is a description, ""corrosive, severe heat-burns in the eyes and skin"" (HSDB (2003)).",,JP_CHRIP,1,C=C1CC(=O)O1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.226B,J-GLOBAL,C=C1CC(=O)O1,Train,1,2702,training
-"NZ_CCID:
-Fenpropimorph",,67564-91-4,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/101A2BA3-D345-4ED0-B7A8-80A80C351416,"NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: A dose of 0.5 ml of fenpropimorph (purity, > 91%) was applied to the intact dorsal skin of four white Vienna rabbits for 3 min or 4 h, and animals were observed up to day 8 after treatment. Fenpropimorph caused slight to moderate erythema and oedema after either application. The reactions intensified, and two of four rabbits had necrosis eight days after the 4-h exposure. In the 3-min test, animals had necrotic-like skin changes and/or scaling.
-REFERENCE SOURCE: 881. Fenpropimorph (Pesticide residues in food: 1994 evaluations Part II Toxicology) Joint Meeting on Pesticide Residues. [INCHEM]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: The irritancy of fenpropimorph to the eye was examined in three white Vienna rabbits in a study in which 0.1 ml of fenpropimorph (purity, > 91%) was instilled into the conjunctival sac of the right eye. Observations were made up to day 8 after instillation. Slight to distinct conjunctival redness was observed in all rabbits. Fenpropimorph was considered to be irritating to the rabbit eye, since slight irritation was still seen at the end of the study.
-REFERENCE SOURCE: 881. Fenpropimorph (Pesticide residues in food: 1994 evaluations Part II Toxicology) Joint Meeting on Pesticide Residues. [INCHEM]",,NZ_CCID,1,C[C@@H]1CN(C[C@@H](O1)C)CC(C)CC2=CC=C(C=C2)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/93365,PubChem,CC(Cc1ccc(C(C)(C)C)cc1)CN1C[C@@H](C)O[C@@H](C)C1,Train,1,2702,training
-"EU_REACH:
-2-(N-methyl-1,1,2,2,3,3,4,4,4-nonafluorobutanesulfonamido)ethyl prop-2-enoate",,67584-55-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11481/7/4/2/?documentUUID=1441e1f1-2cc3-40bd-b329-312fc9cd77e1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(CCOC(=O)C=C)S(=O)(=O)C(C(C(C(F)(F)F)(F)F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/105447,PubChem,C=CC(=O)OCCN(C)S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train,1,2702,training
-"EU_REACH:
-(S)-3,7-Dimethyloct-6-en-1-yl acetate",,67601-05-2,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25684/7/4/2/?documentUUID=06e06e11-c23e-4fa0-8bd1-ecd7ac72f012,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H](CCC=C(C)C)CCOC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/6999975,PubChem,CC(=O)OCC[C@@H](C)CCC=C(C)C,Train,1,2702,training
-"EU_REACH:
-(3Z)-hex-3-en-1-yl methyl carbonate",,67633-96-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19877/7/4/2/?documentUUID=98250679-1eb5-4a29-b57a-fb23e8e7db69,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC/C=C\CCOC(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/5365699,PubChem,CC/C=C\CCOC(=O)OC,Train,1,2702,training
-"EU_REACH:
-2-{[(2R)-3,5-dimethylhex-3-en-2-yl]oxy}-2-methylpropyl cyclopropanecarboxylate; 2-{[(2S)-3,5-dimethylhex-3-en-2-yl]oxy}-2-methylpropyl cyclopropanecarboxylate",,676532-44-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32813/7/4/2/?documentUUID=3f50d90a-da73-4ac4-a6ec-a17c86f395ca,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C=C(C)C(C)OC(C)(C)COC(=O)C1CC1,https://pubchem.ncbi.nlm.nih.gov/compound/66769843,PubChem,CC(=CC(C)C)C(C)OC(C)(C)COC(=O)C1CC1,Train,1,2702,training
-"AU_HCIS:
-chloroform
-
-JP_CHRIP:
-Chloroform
-
-KR_NCIS:
-Chloroform
-
-NZ_CCID:
-Chloroform
-
-US_HSDB:
-Chloroform","AU_HCIS:
-trichloromethane
-Methane, trichloro-
-
-JP_CHRIP:
-FLON-20
-Formyl trichloride
-Methane trichloride
-Trichloromethane
-
-KR_NCIS:
-Trichloromethane
-
-NZ_CCID:
-Methane trichloride, Methane, trichloro-, R20, Trichloromethane",67-66-3,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4753
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0086e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/74E1567E-1937-4DB8-8FBB-B0D34247847B
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/56","JP_CHRIP:
-There are reports from skin irritation tests with rabbits that as a result of a 24-hour application of an undiluted solution of this substance to abdominal skin, mild hyperemia, moderate necrosis, and eschar formation were observed (EHC 163 (1994), Hazard Assessment Report (CERI, NITE, 2008)), and that severe irritation was observed by an application of an undiluted solution of this substance (DFG Vol.14 (2000)). In addition, there is a report that as a result of an application of this substance 1-4 times to rabbit ears, slight hyperemia and epidermolysis were observed (EHC 163 (1994), Hazard Assessment Report (CERI, NITE, 2008)). There is a description that this substance is irritating to the skin (OEL Documentations (Japan Society For Occupational Health (JSOH), 2005), CICAD 58 (2004)). From the above, it was classified in Category 2. Besides, this substance was classified as ""Skin. Irrit. 2 H315"" in EU CLP classification (ECHA CL Inventory (Access on September 2015)). The category was changed because there was no information on irreversible effects.
-
-NZ_CCID:
-Skin Irritation
-R-PHRASE: R 38 Irritating to skin. [N-CLASS]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Severe
-Eye Irritation, with mydriasis and keratitis. Translucent zones in the cornea were observed in four animals and a purulent haemorrhagic discharge was also reported. The effects had disappeared 2-3 weeks after application, except for one rabbit that still showed corneal opacity after 3 weeks.
-REFERENCE SOURCE: Chloroform (EHC 163, 1994) [INCHEM]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,ClC(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.366C,J-GLOBAL,ClC(Cl)Cl,Train,1,2702,training
-"EU_REACH:
-ethyl 3,5,5-trimethylhexanoate",,67707-75-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19592/7/4/2/?documentUUID=7f762d62-bf8d-4d4a-832b-e17da61a9985,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CC(C)CC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/3017783,PubChem,CCOC(=O)CC(C)CC(C)(C)C,Train,1,2702,training
-"JP_CHRIP:
-Alcohol (C=10-16)","JP_CHRIP:
-(C10-C16) Alkyl alcohol; SDA 15-060-00
-Alcohols, C10-16",67762-41-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-0084e.html,"JP_CHRIP:
-It was classified as ""Not classified"" because it is reported that the average scores after 72 hours for erythema and edema were 0.3 and 0.2 in a skin corrosion test with rabbits according to OECD TG 404, and the symptoms disappeared within seven days (SIDS (2007)).",Provided,JP_CHRIP,1,CCCCCCCCCCCCCCO,https://pubchem.ncbi.nlm.nih.gov/compound/8209,PubChem,CCCCCCCCCCCCCCO,Train,1,2702,training
-"AU_HCIS:
-Isooctadecanamide, N-[3-(dimethylamino)propyl]-",,67799-04-6,Cat 1,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6767,,,AU_HCIS,1,CC(C)CCCCCCCCCCCCCCC(=O)NCCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/105621,PubChem,CC(C)CCCCCCCCCCCCCCC(=O)NCCCN(C)C,Train,1,2702,training
-"AU_HCIS:
-3-Buten-2-one, 3-methyl-4-(2,4,6-trimethyl-3-cyclohexen-1-yl)-",,67801-29-0,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5912,,,AU_HCIS,1,CC1CC(=CC(C1C=C(C)C(=O)C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/106819,PubChem,CC(=O)C(C)=CC1C(C)C=C(C)CC1C,Train,1,2702,training
-"AU_HCIS:
-4-Penten-3-one, 5-(2,4,6-trimethyl-3-cyclohexen-1-yl)-",,67801-30-3,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5913,,,AU_HCIS,1,CCC(=O)/C=C/C1C(CC(=CC1C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6437270,PubChem,CCC(=O)/C=C/C1C(C)C=C(C)CC1C,Train,1,2702,training
-"AU_HCIS:
-3-Buten-2-one, 3-methyl-4-(3,5,6-trimethyl-3-cyclohexen-1-yl)-",,67801-31-4,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5914,,,AU_HCIS,1,CC1C=C(CC(C1C)/C=C(\C)/C(=O)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6437271,PubChem,CC(=O)/C(C)=C/C1CC(C)=CC(C)C1C,Train,1,2702,training
-"AU_HCIS:
-4-Penten-3-one, 5-(3,5,6-trimethyl-3-cyclohexen-1-yl)-",,67801-32-5,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5915,,,AU_HCIS,1,CCC(=O)/C=C/C1CC(=CC(C1C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6437272,PubChem,CCC(=O)/C=C/C1CC(C)=CC(C)C1C,Train,1,2702,training
-"AU_HCIS:
-3-Buten-2-one, 4-(2,4,6-trimethyl-3-cyclohexen-1-yl)-",,67801-38-1,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5916,,,AU_HCIS,1,CC1CC(=CC(C1/C=C/C(=O)C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6285057,PubChem,CC(=O)/C=C/C1C(C)C=C(C)CC1C,Train,1,2702,training
-"AU_HCIS:
-3-Buten-2-one, 4-(3,5,6-trimethyl-3-cyclohexen-1-yl)-",,67801-39-2,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5917,,,AU_HCIS,1,CC1C=C(CC(C1C)/C=C/C(=O)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/5355456,PubChem,CC(=O)/C=C/C1CC(C)=CC(C)C1C,Train,1,2702,training
-"EU_REACH:
-2-tert-butylcyclohexyl ethyl carbonate",,67801-64-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20369/7/4/2/?documentUUID=59f4d925-5d6a-4663-b5d2-1a79b2c75066,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)OC1CCCCC1C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/105664,PubChem,CCOC(=O)OC1CCCCC1C(C)(C)C,Train,1,2702,training
-"EU_REACH:
-hexadecyl 3,5-di-tert-butyl-4-hydroxybenzoate",,67845-93-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5453/7/4/2/?documentUUID=d1b62fef-3a80-4920-81fc-ef26fd0aba1a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCCCOC(=O)C1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/94623,PubChem,CCCCCCCCCCCCCCCCOC(=O)c1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1,Train,1,2702,training
-"EU_REACH:
-diisotridecyl phenyl phosphite",,67874-37-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23926/7/4/2/?documentUUID=b9601a9d-8ca8-42c4-b37d-d43e0db45f11,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCCCCCCOP(OCCCCCCCCCCC(C)C)OC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/105872,PubChem,CC(C)CCCCCCCCCCOP(OCCCCCCCCCCC(C)C)Oc1ccccc1,Train,1,2702,training
-"EU_REACH:
-3,3'-[[4-[(2,6-dichloro-4-nitrophenyl)azo]phenyl]imino]bispropiononitrile",,67923-43-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21965/7/4/2/?documentUUID=4aa0185c-b47d-4145-9fbd-0d4ed220d92b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1N=NC2=C(C=C(C=C2Cl)[N+](=O)[O-])Cl)N(CCC#N)CCC#N,https://pubchem.ncbi.nlm.nih.gov/compound/106138,PubChem,N#CCCN(CCC#N)c1ccc(N=Nc2c(Cl)cc([N+](=O)[O-])cc2Cl)cc1,Train,1,2702,training
-"NZ_CCID:
-3-Cyclohexene-1-carboxaldehyde, 2,4-dimethyl-","NZ_CCID:
-Ligustral",68039-49-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BBFF29FE-73DB-4AEA-A151-5349EC686170,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 38 [http://www.thesoapkitchen.co.uk/images/MSDS/fragrances/MSDS%20Ocean%20Fragrance,%20Soap%20Kitchen.pdf]
-Eye Irritation
-R-PHRASE: R 36 [http://www.thesoapkitchen.co.uk/images/MSDS/fragrances/MSDS%20Ocean%20Fragrance,%20Soap%20Kitchen.pdf]",,NZ_CCID,1,CC1C=C(CCC1C=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/93375,PubChem,CC1=CC(C)C(C=O)CC1,Train,1,2702,training
-"EU_REACH:
-(3-chloro-2-fluorophenyl)(2,4-dimethoxyphenyl)methanone",,680610-70-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18430/7/4/2/?documentUUID=d39ccf2d-8349-4240-8fa5-5f4545f31677,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC(=C(C=C1)C(=O)C2=C(C(=CC=C2)Cl)F)OC,https://pubchem.ncbi.nlm.nih.gov/compound/64713965,PubChem,COc1ccc(C(=O)c2cccc(Cl)c2F)c(OC)c1,Train,1,2702,training
-"AU_HCIS:
-Acetic acid, mercapto-
-
-JP_CHRIP:
-Mercaptoacetic acid
-
-KR_NCIS:
-Mercaptoacetic acid
-
-NZ_CCID:
-Thioglycolic acid
-
-US_HSDB:
-MERCAPTOACETIC ACID","AU_HCIS:
-thioglycolic acid
-Mercaptoacetic acid
-Thiovanic acid
-2-Mercaptoacetate
-2-Sulfanylacetic acid
-
-JP_CHRIP:
-2-Mercaptoethanoic acid
-Ethanethiol-2-acid-1
-mercaptoacetic acid
-Thioglycolic acid
-
-KR_NCIS:
-thioglycolic acid
-
-NZ_CCID:
-2-Mercaptoacetate, 2-Thioglycolic acid, Acetic acid, mercapto-, Glycolic acid, 2-thio-, Mercaptoacetic acid, Thioglycolate, Thioglycollic acid",68-11-1,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=54
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2106e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AE50DEFC-48BD-4B2A-88BB-9F41F47E1439
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/2702","JP_CHRIP:
-Since necrosis was observed within 5 minutes after application of the undiluted liquid of this substance to the skin of rabbits, this substance was judged to be corrosive (SIDS (2010)). In humans, there are reports that by exposure to this substance at a high concentration, it caused a second-degree burn on the skin (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), and that ulcers and a permanent scar were observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). From the above results, it was classified in Category 1. Besides, this substance was classified as ""R34"" in the EU DSD classification, and as ""Skin Corr. 1B H314"" in the EU CLP classification.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,OC(=O)CS,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.856I,J-GLOBAL,O=C(O)CS,Train,1,2702,training
-"JP_CHRIP:
-N,N-Dimethylformamide","JP_CHRIP:
-Dimethylformamide
-DMF
-DMFA
-Formamide, N,N-dimethyl-
-Formyldimethylamine
-N-formyldimethylamine",68-12-2,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2079e.html,"JP_CHRIP:
-[Rationale for the Classification]
-Because there are multiple pieces of evidence that this substance is irritating from (1)-(6), it was classified in Category 2. Besides, the previous category was revised by using new information sources.
-
-[Evidence Data]
-(1) There are multiple pieces of information that exposure to this substance causes symptoms of skin irritation and eruption in humans, and it is reported that it is slightly to moderately irritating to the skin (ACGIH (2018), CICAD (2001)).
-(2) A 52-year-old man who accidentally contacted this substance (about 20% of the body surface) washed himself, dressed, and drove home, and skin inflammation and hyperemia are reported as symptoms after 45 minutes (PATTY (6th, 2012), Ministry of Health, Labour and Welfare Hazard Assessment Report (CERI, NITE, 2017)).
-(3) It is reported that 21-year-old and 28-year-old men who exposed to this substance at work developed erythematous rash in their hands and forearms (Ministry of Health, Labour and Welfare Hazard Assessment Report (CERI, NITE, 2017)).
-(4) It is reported that after this substance was applied to the skin of mice at 500 mg/kg body weight, transient irritation was observed after 2-3 hours, and slight irritation was found at 2,500 and 5,000 mg/kg body weight (EHC (1991), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Ministry of Health, Labour and Welfare Hazard Assessment Report (CERI, NITE, 2017)).
-(5) It is reported that when this substance was applied to the skin of rats at 94, 472, 944 mg/kg body weight, skin irritation was shown at 944 mg/kg body weight (PATTY (6th, 2012)).
-(6) It is reported that when this substance was applied to the skin of rabbits at 100, 200, 400 mg/kg body weight, it was irritating to the skin at 400 mg/kg body weight (PATTY (6th, 2012)).
-(7) In the notice regarding guidelines to prevent health problems, this substance was designated as a substance strongly irritating the skin, eye, and mucous membrane (the notice No. 0614001 issued by Director of Labour Standards Bureau, the Ministry of Health, Labour and Welfare, demolished by the notice No. 0331-26, March 31, 2016).
-
-[Reference Data, etc.]
-(8) In the announcement No. 33 of the Ministry of Labour (1996) (revised by the announcement No. 316 of the Ministry of Health, Labour and Welfare, 2013), this substance is designated as ""dimethylformamide"" in Simple chemical substances or compounds designated by the Minister of Health, Labour and Welfare based on Appended Table 1-2, (iv) 1 of the Ordinance for Enforcement of the Labor Standards Act, and a disease principally having specific symptoms and disorders (subjective symptoms such as headaches, dizziness, and vomiting, and skin disorders, anterior eye disorders, respiratory tract disorders, liver disorders, or gastrointestinal disorders) due to work involving exposure to this substance was designated as an occupational disease by the Minister of Health, Labour and Welfare.
-(9) In the notice No. 0811001 issued by Director of Labour Standards Bureau, the Ministry of Labour (2003), this substance is designated as ""dimethylformamide"" among hazardous substances for which installation of protective equipment to prevent eye disorders such as protective glasses is mandated in Article 593 in the Industrial Safety and Health Regulations.",,JP_CHRIP,1,CN(C)C=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.923B,J-GLOBAL,CN(C)C=O,Train,1,2702,training
-"JP_CHRIP:
-Tetramethyl silicate
-
-NZ_CCID:
-Tetramethyl orthosilicate","JP_CHRIP:
-Tetramethoxy silane
-Tetramethoxysilane
-Tetramethyl silicate
-
-NZ_CCID:
-Methyl Silicate 39, Methyl orthosilicate, Methyl silicate ((CH3)4SiO4), Methyl silicate ((MeO)4Si), Methyl silicate 28, Methyl silicate, ((MeO)4Si), Silane, tetramethoxy-, Silicic acid (H4SiO4), tetramethyl ester, Tetra-methyl orthosilicate, Tetramethoxysilane, Tetramethyl silicate",681-84-5,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0222e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8AA0571A-098F-4855-A74C-12E1ECB6A2B5","JP_CHRIP:
-It was classified as Category 2 from description that the skin is stimulated seriously (ICSC (J) (1997), HSFS (1999), and SITTIG (4th, 2002)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 41 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CO[Si](OC)(OC)OC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J36.490H,J-GLOBAL,CO[Si](OC)(OC)OC,Train,1,2702,training
-"AU_HCIS:
-Betaines, coco alkyldimethyl(3-sulfopropyl)",,68201-55-8,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=498,,,AU_HCIS,1,CCCCCCCCCCCC[N+](C)(C)CCCS(=O)(=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/84703,PubChem,CCCCCCCCCCCC[N+](C)(C)CCCS(=O)(=O)[O-],Train,1,2702,training
-"EU_REACH:
-tetrapropyl silicate",,682-01-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14206/7/4/2/?documentUUID=1d275aa8-1c8c-488f-a247-02da1d410fc5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCO[Si](OCCC)(OCCC)OCCC,https://pubchem.ncbi.nlm.nih.gov/compound/69627,PubChem,CCCO[Si](OCCC)(OCCC)OCCC,Train,1,2702,training
-"EU_REACH:
-2,2-bis[(prop-2-en-1-yloxy)methyl]butan-1-ol",,682-09-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1894/7/4/2/?documentUUID=00fd4203-7263-4323-aa29-bf5ecc24e1a7,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(CO)(COCC=C)COCC=C,https://pubchem.ncbi.nlm.nih.gov/compound/61196,PubChem,C=CCOCC(CC)(CO)COCC=C,Train,1,2702,training
-"EU_REACH:
-N-(5-chloro-2-methylphenyl)-3-hydroxy-4-{[2-methoxy-5-(phenylcarbamoyl)phenyl]diazenyl}-2-naphthamide",,68227-78-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11197/7/4/2/?documentUUID=cbdd0d1c-9c55-4445-9c87-4517d48a9540,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)Cl)NC(=O)C2=CC3=CC=CC=C3C(=C2O)N=NC4=C(C=CC(=C4)C(=O)NC5=CC=CC=C5)OC,https://pubchem.ncbi.nlm.nih.gov/compound/109852,PubChem,COc1ccc(C(=O)Nc2ccccc2)cc1N=Nc1c(O)c(C(=O)Nc2cc(Cl)ccc2C)cc2ccccc12,Train,1,2702,training
-"AU_HCIS:
-Cyclohexane, 2-heptyl-3,4-bis(9-isocyanatononyl)-1-pentyl-",,68239-06-5,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5456,,,AU_HCIS,1,CCCCCCCC1C(CCC(C1CCCCCCCCCN=C=O)CCCCCCCCCN=C=O)CCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/109248,PubChem,CCCCCCCC1C(CCCCC)CCC(CCCCCCCCCN=C=O)C1CCCCCCCCCN=C=O,Train,1,2702,training
-"EU_REACH:
-1,1,2,2,3,3,4,4,4-nonafluoro-N-methylbutane-1-sulfonamide",,68298-12-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32215/7/4/2/?documentUUID=0725645f-d96b-427e-a892-8980163cd557,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CNS(=O)(=O)C(C(C(C(F)(F)F)(F)F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/109968,PubChem,CNS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train,1,2702,training
-"NZ_CCID:
-Sulphadiazine",,68-35-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/05A40E8A-5563-411A-9D91-A513D3A69237,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [SIGMA-ALDRICH]
-Eye Irritation
-R PHRASE: R 36 [SIGMA-ALDRICH]",,NZ_CCID,1,C1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N,https://pubchem.ncbi.nlm.nih.gov/compound/5215,PubChem,Nc1ccc(S(=O)(=O)Nc2ncccn2)cc1,Train,1,2702,training
-"EU_REACH:
-N-[2-[(2,6-dicyano-p-tolyl)azo]-5-(diethylamino)phenyl]methanesulphonamide",,68385-96-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22379/7/4/2/?documentUUID=fafa7b1e-f5cb-46c9-b53d-2aa8df918f10,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(CC)C1=CC(=C(C=C1)N=NC2=C(C=C(C=C2C#N)C)C#N)NS(=O)(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/110090,PubChem,CCN(CC)c1ccc(N=Nc2c(C#N)cc(C)cc2C#N)c(NS(C)(=O)=O)c1,Train,1,2702,training
-"NZ_CCID:
-Alcohols, C6-12, ethoxylated (5 > EO < 20)",,68439-45-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0DA8FD09-F8C7-488D-980E-F894A1A2DA1C,"NZ_CCID:
-Skin Irritation
-REMARK: Alcohol ethoxylates are according to CESIO (2000) classified as Irritant or Harmful depending on the number of EO-units: EO < 5 gives Irritant (Xi) with R38 (Irritating to skin) and R41 (Risk of serious damage to eyes). EO > 5-15 gives Harmful (Xn) with R22 (Harmful if swallowed) - R38/41. EO > 15-20 gives Harmful (Xn) with R22-41
-REFERENCE SOURCE: Danish EPA 2001 Environmental and Health Assessment of Substances in Household Detergents and Cosmetic Detergent Products Environmental Project 651
-Eye Irritation
-REMARK: Alcohol ethoxylates are according to CESIO (2000) classified as Irritant or Harmful depending on the number of EO-units: EO < 5 gives Irritant (Xi) with R38 (Irritating to skin) and R41 (Risk of serious damage to eyes). EO > 5-15 gives Harmful (Xn) with R22 (Harmful if swallowed) - R38/41. EO > 15-20 gives Harmful (Xn) with R22-41
-REFERENCE SOURCE: Danish EPA 2001 Environmental and Health Assessment of Substances in Household Detergents and Cosmetic Detergent Products Environmental Project 651",,NZ_CCID,1,CCCCCCCCCOCC,https://pubchem.ncbi.nlm.nih.gov/compound/12714344,PubChem,CCCCCCCCCOCC,Train,1,2702,training
-"EU_REACH:
-(1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide",,68489-09-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17595/7/4/2/?documentUUID=54a03fc6-3619-4162-a15c-31b99d0f0339,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H]1CC[C@H]([C@@H](C1)C(=O)NC2=CC=C(C=C2)OC)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11266244,PubChem,COc1ccc(NC(=O)[C@@H]2C[C@H](C)CC[C@H]2C(C)C)cc1,Train,1,2702,training
-"NZ_CCID:
-2-Methoxybenzylamine",,6850-57-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/70B7B829-691E-4EF4-A470-FB478C57D81B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,COC1=CC=CC=C1CN,https://pubchem.ncbi.nlm.nih.gov/compound/81292,PubChem,COc1ccccc1CN,Train,1,2702,training
-"EU_REACH:
-tetramethyl 2,2'-{1,4-phenylenebis[imino(1,3-dioxobutane-2,1-diyl)diazene-2,1-diyl]}diterephthalate",,68516-73-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14162/7/4/2/?documentUUID=9cc390ad-22b8-495e-9ff8-3e2661986c83,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC=C(C=C1)NC(=O)C(C(=O)C)N=NC2=C(C=CC(=C2)C(=O)OC)C(=O)OC)N=NC3=C(C=CC(=C3)C(=O)OC)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/109448,PubChem,COC(=O)c1ccc(C(=O)OC)c(N=NC(C(C)=O)C(=O)Nc2ccc(NC(=O)C(N=Nc3cc(C(=O)OC)ccc3C(=O)OC)C(C)=O)cc2)c1,Train,1,2702,training
-"NZ_CCID:
-2,2,2-Trifluoro-N-methyl-N-(trifluoroacetyl)acetamide","NZ_CCID:
-N-Methyl-bis(trifluoroacetamide)",685-27-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4B8ADE0B-D5D4-4F60-BF11-A1FE26C6D211,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 34. [Chemwatch]
-Eye Irritation
-R-PHRASE: R 34/ 41. [Chemwatch]",,NZ_CCID,1,CN(C(=O)C(F)(F)F)C(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/69635,PubChem,CN(C(=O)C(F)(F)F)C(=O)C(F)(F)F,Train,1,2702,training
-"EU_REACH:
-11-(heptylamino)undecanoic acid",,68564-88-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32718/7/4/2/?documentUUID=522164e3-89c5-44fd-8649-065dfb77ed36,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCNCCCCCCCCCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/110593,PubChem,CCCCCCCNCCCCCCCCCCC(=O)O,Train,1,2702,training
-"NZ_CCID:
-Diethyl bromomalonate","NZ_CCID:
-Propanedioic acid, bromo-, diethyl ester",685-87-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2B1A6C59-1C41-4830-8512-7A7CC7852EA6,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCOC(=O)C(C(=O)OCC)Br,https://pubchem.ncbi.nlm.nih.gov/compound/69637,PubChem,CCOC(=O)C(Br)C(=O)OCC,Train,1,2702,training
-"NZ_CCID:
-3-Piperidinol","NZ_CCID:
-3-hydroxypiperidine",6859-99-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A21EF343-10BC-44D5-92B7-562A78C87891,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1CC(CNC1)O,https://pubchem.ncbi.nlm.nih.gov/compound/23293,PubChem,OC1CCCNC1,Train,1,2702,training
-"NZ_CCID:
-Carboxylic acids, di-, C4-6",,68603-87-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CA37DAD2-77AD-44AD-8ACE-2A1A4F5A0192,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,OC(=O)CCCC(O)=O,https://cactus.nci.nih.gov/chemical/structure/68603-87-2/smiles,CACTUS,O=C(O)CCCC(=O)O,Train,1,2702,training
-"NZ_CCID:
-Oxirane, mono[(C8-10-alkyloxy)methyl] derivs.",,68609-96-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B3459516-D40D-4A26-8E41-33877101CB78,,,NZ_CCID,1,CCCCCCCCCOCC1CO1,https://cactus.nci.nih.gov/chemical/structure/68609-96-1/smiles,CACTUS,CCCCCCCCCOCC1CO1,Train,1,2702,training
-"JP_CHRIP:
-4,4'-Methylenebis(2-methylcyclohexaneamine)
-
-NZ_CCID:
-4,4'-Methylenebis(2-methylcyclohexylamine)","JP_CHRIP:
-2,2'-dimethyl-4,4'-methylenebis(cyclohexylamine)
-2,2'-dimethyl-4,4'-methylenebis(cyclohexylamine) (synonym:4,4'-methylenebis(2-methylcyclohexanamine))
-3,3'-Dimethyl-4,4'-diaminodicyclohexylmethane
-3,3'-Dimethyl-4,4'-diaminodicyclohexylmethane; 3,3'-Dimethyl-4,4'-diaminodicyclohexylmethane
-4,4'-Diamino-3,3'-dimethyldicyclohexylmethane
-4,4'-Methylenebis(2-methylcyclohexaneamine)
-4,4'-Methylenebis-(2-methylcyclohexanamine)",6864-37-5,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0552e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EBA40DD8-8A73-4B0F-8F3B-D62F42A7DEA5","JP_CHRIP:
-Based on the description in the report on rabbit skin irritation tests (SIDS (2005)): ""Corrosive."" Although classified into Category 1A-1C, the substance should be placed in Category 1A from the viewpoint of safety if further subclassification is needed.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 35 [Company Data]
-Eye Irritation
-R PHRASE: R 35 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CC1CC(CC2CCC(N)C(C)C2)CCC1N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J39.615J,J-GLOBAL,CC1CC(CC2CCC(N)C(C)C2)CCC1N,Train,1,2702,training
-"EU_REACH:
-8-ethyl-9-methylheptadecane; 8-methyl-7-propylhexadecane",,68649-11-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13309/7/4/2/?documentUUID=6a980ede-0b74-46ea-8e13-ffa3dcdc5b75,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCC(C)C(C)CCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/530173,PubChem,CCCCCCCCC(C)C(C)CCCCCCCC,Train,1,2702,training
-"EU_REACH:
-(3S)-3,7-Dimethyl-1-octanol",,68680-98-8,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25603/7/4/2/?documentUUID=aeb112fb-24e2-4573-8076-ef8fe8311850,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H](CCCC(C)C)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/6992239,PubChem,CC(C)CCC[C@H](C)CCO,Train,1,2702,training
-"AU_HCIS:
-Amines, tri-C8-10-alkyl",,68814-95-9,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5197,,,AU_HCIS,1,CCCCCCCCCC(CCCCCCCC)N(C(CCCCCCCC)CCCCCCCCC)C(CCCCCCCC)CCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/45382229,PubChem,CCCCCCCCCC(CCCCCCCC)N(C(CCCCCCCC)CCCCCCCCC)C(CCCCCCCC)CCCCCCCCC,Train,1,2702,training
-"JP_CHRIP:
-2-Ethylhexyl methacrylate","JP_CHRIP:
-Methacrylic acid, 2-ethylhexyl ester",688-84-6,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-meti-0021e.html,"JP_CHRIP:
-There are two reports of skin irritation tests with rabbits where as a result of application of this substance (undiluted) for 24 hours, moderate irritation (PII=3.12, 4.04) was observed (SIDS (2009)). It is described in SIDS (2009) that these tests were not compliant with the current standard test (4-hour application), but they were available for judgement on primary skin irritation. Therefore, this substance was classified in Category 2.",,JP_CHRIP,1,CCCCC(CC)COC(=O)C(=C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J41.662B,J-GLOBAL,C=C(C)C(=O)OCC(CC)CCCC,Train,1,2702,training
-"EU_REACH:
-allyl (cyclohexyloxy)acetate",,68901-15-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25443/7/4/2/?documentUUID=5fd03e45-bccb-4d99-bbe2-927985fd6ad7,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CCOC(=O)COC1CCCCC1,https://pubchem.ncbi.nlm.nih.gov/compound/111727,PubChem,C=CCOC(=O)COC1CCCCC1,Train,1,2702,training
-"NZ_CCID:
-Fatty acids, C8-10",,68937-75-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/62C4B95C-FF32-47E8-AB4B-05863F23C0E1,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,CCCCCCCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/8158,PubChem,CCCCCCCCC(=O)O,Train,1,2702,training
-"NZ_CCID:
-Siloxanes and silicones, di-Me, 3-hydroxypropyl Me, ethers with polyethylene glycol mono-Me ether",,68938-54-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4C42C17C-9A75-4D14-8FB5-2BBE0ADB6877,"NZ_CCID:
-Skin Irritation
-R-PHRASE: R 38 Irritating to skin. [MSDS]
-Eye Irritation
-R-PHRASE: R 41 Risk of serious damage to eyes. [MSDS]",,NZ_CCID,1,COCCOCCC[Si](C)(O[Si](C)(C)C)O[Si](C)(C)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/54165714,PubChem,COCCOCCC[Si](C)(O[Si](C)(C)C)O[Si](C)(C)O[Si](C)(C)C,Train,1,2702,training
-"EU_REACH:
-Amines, C12-18(even numbered)-alkyldimethyl, N-oxides",,68955-55-5,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14371/7/4/2/?documentUUID=e0fbfdfd-a04c-44c3-9e76-e29d3f5d87b1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCC[N+](C)(C)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/9860272,PubChem,CCCCCCCCCCCCCCC[N+](C)(C)[O-],Train,1,2702,training
-"EU_REACH:
-(4E)-5,9-dimethyldec-4-enal; (4Z)-5,9-dimethyldec-4-enal
-
-KR_NCIS:
-5,9-Dimethyl-4-decenal; 689-65-6",,689-65-6,Cat 2,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29343/7/4/2/?documentUUID=821dbe07-d87a-4302-a608-f2c67126293f
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,"EU_REACH, KR_NCIS",2,CC(C)CCCC(=CCCC=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/53858163,PubChem,CC(=CCCC=O)CCCC(C)C,Train,1,2702,training
-"EU_CLP:
-3-(2'-phenoxyethoxy)propylamine",,6903-18-0,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC=C(C=C1)OCCOCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/18702439,PubChem,NCCCOCCOc1ccccc1,Test,1,2702,training
-"EU_CLP:
-2,2-dibromo-2-nitroethanol",,69094-18-4,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C(C([N+](=O)[O-])(Br)Br)O,https://pubchem.ncbi.nlm.nih.gov/compound/93395,PubChem,O=[N+]([O-])C(Br)(Br)CO,Test,1,2702,training
-"JP_CHRIP:
-DL-Malic acid
-
-NZ_CCID:
-Malic acid
-
-US_HSDB:
-MALIC ACID","JP_CHRIP:
-DL-malic acid
-
-NZ_CCID:
-Hydroxybutanedioic acid, Hydroxysuccinic acid, Butanedioic acid, hydroxy-, Deoxytetraric acid, pomalus acid, 2-Hydroxyethane-1,2-dicarboxylic acid",6915-15-7,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0119e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A8C4383C-99E7-466D-AEF8-22B7BB2BEC87
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1202","JP_CHRIP:
-On the basis of moderately irritating reported as a result of a test applied 20 mg or 500 mg to rabbit skin for 24 hours (PATTY (5th, 2001)), it was classified in Category 2.
-
-NZ_CCID:
-Skin Irritation
-SPECIES:
-RESULT: Irritant
-REFERENCE SOURCE: Sax, N.I. Dangerous Properties of Industrial Materials. 6th ed. New York, NY: Van Nostrand Reinhold, 1984. 1727 **PEER REVIEWED** [HSDB]
-Eye Irritation
-SPECIES:
-RESULT: Irritant
-REFERENCE SOURCE: Sax, N.I. Dangerous Properties of Industrial Materials. 6th ed. New York, NY: Van Nostrand Reinhold, 1984. 1727 **PEER REVIEWED** [HSDB]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,OC(CC(=O)O)C(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.091K,J-GLOBAL,O=C(O)CC(O)C(=O)O,Train,1,2702,training
-"NZ_CCID:
-1-Amino-4-methylpiperazine",,6928-85-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/275F82F0-85AB-4D76-927D-3482C9440AA4,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CN1CCN(CC1)N,https://pubchem.ncbi.nlm.nih.gov/compound/81349,PubChem,CN1CCN(N)CC1,Train,1,2702,training
-"NZ_CCID:
-1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane",,69304-37-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/54680F26-E1C2-45EC-AB17-4152C39EE9F1,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)[Si](C(C)C)(O[Si](C(C)C)(C(C)C)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/172404,PubChem,CC(C)[Si](Cl)(O[Si](Cl)(C(C)C)C(C)C)C(C)C,Train,1,2702,training
-"NZ_CCID:
-2-Aminooctane","NZ_CCID:
-2-octylamine",693-16-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/998D22A7-4C4D-4C5E-9724-174F0812914E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCCCCCC(C)N,https://pubchem.ncbi.nlm.nih.gov/compound/12735,PubChem,CCCCCCC(C)N,Train,1,2702,training
-"EU_REACH:
-1-chloro-2,5-dimethoxy-4-nitrobenzene",,6940-53-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1976/7/4/2/?documentUUID=2f14d586-e514-49c2-bafc-a58016022bae,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC(=C(C=C1[N+](=O)[O-])OC)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/81362,PubChem,COc1cc([N+](=O)[O-])c(OC)cc1Cl,Train,1,2702,training
-"ChemSkin:
-1-Bromo-4-chlorobutane #",,6940-78-9,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,C(CCBr)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/81364,PubChem,ClCCCCBr,Test,1,2702,training
-"NZ_CCID:
-1-Bromo-2-chlorobenzene","NZ_CCID:
-2-bromochlorobenzene",694-80-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6E5C16B1-6E3B-4204-9282-2CB6C689245E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)Cl)Br,https://pubchem.ncbi.nlm.nih.gov/compound/12754,PubChem,Clc1ccccc1Br,Train,1,2702,training
-"NZ_CCID:
-1,2-Cyclohexanediamine",,694-83-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4217BFAB-BED3-406F-A1C5-EA4F24B0C36C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1CCC(C(C1)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/4610,PubChem,NC1CCCCC1N,Train,1,2702,training
-"NZ_CCID:
-2-Amino-4-methylpyridine",,695-34-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1FC4F20F-A9D3-4475-B058-A2FF72DE5944,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=CC(=NC=C1)N,https://pubchem.ncbi.nlm.nih.gov/compound/1533,PubChem,Cc1ccnc(N)c1,Train,1,2702,training
-"EU_REACH:
-N-(4-amino-3-methoxy-9,10-dioxo-9,10-dihydroanthracen-1-yl)benzenesulfonamide",,69563-51-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15911/7/4/2/?documentUUID=79c092b4-8345-4742-9545-1376b092972b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=C(C2=C(C(=C1)NS(=O)(=O)C3=CC=CC=C3)C(=O)C4=CC=CC=C4C2=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/112289,PubChem,COc1cc(NS(=O)(=O)c2ccccc2)c2c(c1N)C(=O)c1ccccc1C2=O,Train,1,2702,training
-"EU_REACH:
-N-(2-methoxy-5-methylphenyl)acetamide",,6962-44-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5717/7/4/2/?documentUUID=e5130861-e6cc-412e-95a4-577f97b05323,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)OC)NC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/81412,PubChem,COc1ccc(C)cc1NC(C)=O,Train,1,2702,training
-"NZ_CCID:
-Cyclooctanol",,696-71-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C3D2D0D9-63EE-4877-AE86-EC547C65F235,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1CCCC(CCC1)O,https://pubchem.ncbi.nlm.nih.gov/compound/12766,PubChem,OC1CCCCCCC1,Train,1,2702,training
-"EU_REACH:
-2-((3-(4-Hydroxyphenyl)propanoylamino)benzoic acid",,697235-49-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11048/7/4/2/?documentUUID=f2e7a539-cf63-4d0f-9960-77de0e469081,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=C1)C(=O)O)NC(=O)CCC2=CC=C(C=C2)O,https://pubchem.ncbi.nlm.nih.gov/compound/10334118,PubChem,O=C(CCc1ccc(O)cc1)Nc1ccccc1C(=O)O,Train,1,2702,training
-"NZ_CCID:
-Butyldimethylsilyl trifluoromethanesulphonate, t-",,69739-34-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/24743BCA-FCE4-4CBD-81BC-1BD585C4E393,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/123564,PubChem,CC(C)(C)[Si](C)(C)OS(=O)(=O)C(F)(F)F,Train,1,2702,training
-"EU_REACH:
-1-bromo-3-chloro-2-methylpropane",,6974-77-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20108/7/4/2/?documentUUID=71ea0ac0-1cd9-4a72-9c07-14245a1f7b40,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CCl)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/95566,PubChem,CC(CCl)CBr,Train,1,2702,training
-"EU_REACH:
-2-methoxyethyl 2-methylprop-2-enoate",,6976-93-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23723/7/4/2/?documentUUID=7c0bff77-f899-49b4-98a4-92c2f06b9072,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OCCOC,https://pubchem.ncbi.nlm.nih.gov/compound/81466,PubChem,C=C(C)C(=O)OCCOC,Train,1,2702,training
-"NZ_CCID:
-2,3,5-Trimethylphenol",,697-82-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C2EB33CB-5CB9-49CB-B365-BF468E5CCD60,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=CC(=C(C(=C1)O)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/12769,PubChem,Cc1cc(C)c(C)c(O)c1,Train,1,2702,training
-"EU_REACH:
-4-[(1E)-2-(2,5-dichlorophenyl)diazen-1-yl]-3-hydroxy-N-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl)naphthalene-2-carboxamide",,6992-11-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10288/7/4/2/?documentUUID=e1ed9a77-30e4-471b-84d3-da90e6a54f7f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C=C(C(=C2N=NC3=C(C=CC(=C3)Cl)Cl)O)C(=O)NC4=CC5=C(C=C4)NC(=O)N5,https://pubchem.ncbi.nlm.nih.gov/compound/81471,PubChem,O=C(Nc1ccc2[nH]c(=O)[nH]c2c1)c1cc2ccccc2c(N=Nc2cc(Cl)ccc2Cl)c1O,Train,1,2702,training
-"NZ_CCID:
-Pentamethylbenzene",,700-12-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B14D4F9C-BC93-4B12-9D0D-FA352D2F2C37,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=CC(=C(C(=C1C)C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/12784,PubChem,Cc1cc(C)c(C)c(C)c1C,Train,1,2702,training
-"JP_CHRIP:
-2,3,5-Trimethylhydroquinone","JP_CHRIP:
-2,3,5-Trimethylbenzene-1,4-diol",700-13-0,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0108e.html,"JP_CHRIP:
-It was corrosive in a test by a 4-hour occlusive application to rabbits (IUCLID (2000)), and in a test by a 4-hour occlusive application of an 80% aqueous solution of this substance to rabbits, severe erythema and slight edema remained after eight days, necrosis was also recorded, and it was judged as corrosive (IUCLID (2000)). Therefore, it was classified in Category 1. Besides, it was classified in Xi: R37/38 in EU classification.",,JP_CHRIP,1,Cc1cc(O)c(C)c(C)c1O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J12.289K,J-GLOBAL,Cc1cc(O)c(C)c(C)c1O,Train,1,2702,training
-"EU_REACH:
-(2R,5S)-2-{4'-[difluoro(3,4,5-trifluorophenoxy)methyl]-3',5'-difluoro-[1,1'-biphenyl]-4-yl}-5-propyloxane",,700863-48-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24296/7/4/2/?documentUUID=99fa2a58-f803-4f68-98a3-d02419f7cf09,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC[C@@H]1CC[C@H](OC1)C2=CC=C(C=C2)C3=CC(=C(C(=C3)F)C(OC4=CC(=C(C(=C4)F)F)F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/165366977,PubChem,CCC[C@@H]1CC[C@@H](c2ccc(-c3cc(F)c(C(F)(F)Oc4cc(F)c(F)c(F)c4)c(F)c3)cc2)OC1,Train,1,2702,training
-"AU_HCIS:
-1-Hexen-3-one, 5-methyl-1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-",,70092-23-8,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5918,,,AU_HCIS,1,CC1=CCCC(C1/C=C/C(=O)CC(C)C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6437739,PubChem,CC1=CCCC(C)(C)C1/C=C/C(=O)CC(C)C,Train,1,2702,training
-"NZ_CCID:
-2-Bromoacetophenone",,70-11-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F990AE84-7D44-4CCF-822D-B5669CC18E55,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C(C=C1)C(=O)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/6259,PubChem,O=C(CBr)c1ccccc1,Train,1,2702,training
-"US_HSDB:
-Phenylphosphate",,701-64-4,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8430,,,US_HSDB,1,C1=CC=C(C=C1)OP(=O)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/12793,PubChem,O=P(O)(O)Oc1ccccc1,Train,1,2702,training
-"NZ_CCID:
-3-Cyclohexylpropionic acid","NZ_CCID:
-cyclohexanepropionic acid",701-97-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2B12F547-1A5D-44C0-ABFC-54D6BD09A627,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 36 [Company Data]
-Eye Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C1CCC(CC1)CCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/69702,PubChem,O=C(O)CCC1CCCCC1,Train,1,2702,training
-"NZ_CCID:
-Ethyl bromopyruvate, >10% in a non hazardous diluent",,70-23-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/98CA8F3F-9FCE-4D71-888E-2B15DC3535B4,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCOC(=O)C(=O)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/66144,PubChem,CCOC(=O)C(=O)CBr,Train,1,2702,training
-"EU_REACH:
-2-Chloro-5-chloromethylpyridine",,70258-18-3,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11962/7/4/2/?documentUUID=1b35f78f-7df5-4f11-820e-8ec9dc90d3e8,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=NC=C1CCl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/155479,PubChem,ClCc1ccc(Cl)nc1,Train,1,2702,training
-"EU_CLP:
-methyl 4-bromomethyl-3-methoxybenzoate",,70264-94-7,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,COC1=C(C=CC(=C1)C(=O)OC)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/2759828,PubChem,COC(=O)c1ccc(CBr)c(OC)c1,Test,1,2702,training
-"JP_CHRIP:
-1-Fluoro-2,4-dinitrobenzene",,70-34-8,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0132e.html,"JP_CHRIP:
-In addition to the information that this substance is a strong skin irritant (Contact Dermatitis (4th, 2006), corresponding to List 1), on the basis of a description of a powerful irritant and a vesicant (HSDB (2003)), it was classified in Category 2.",,JP_CHRIP,1,[O-][N+](=O)c1ccc(F)c(c1)[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.936D,J-GLOBAL,O=[N+]([O-])c1ccc(F)c([N+](=O)[O-])c1,Train,1,2702,training
-"EU_REACH:
-4-fluoro-N-(propan-2-yl)aniline",,70441-63-3,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5456/7/4/2/?documentUUID=ed46c017-f4c1-43d7-b8a3-aab072067dd2,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)NC1=CC=C(C=C1)F,https://pubchem.ncbi.nlm.nih.gov/compound/154403,PubChem,CC(C)Nc1ccc(F)cc1,Train,1,2702,training
-"NZ_CCID:
-Mercaptosuccinic acid","NZ_CCID:
-thiomalic acid",70-49-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/27111D5B-546F-42B5-89BC-512D8DCB048B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(C(C(=O)O)S)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/6268,PubChem,O=C(O)CC(S)C(=O)O,Train,1,2702,training
-"NZ_CCID:
-3-(Trifluoromethyl)-benzyl chloride",,705-29-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3ABE1E93-59AA-489D-A849-711D6835A8EA,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)C(F)(F)F)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/69716,PubChem,FC(F)(F)c1cccc(CCl)c1,Train,1,2702,training
-"EU_CLP:
-N-[3-[(2-acetyloxy)ethyl](phenyl-methyl)amino]-4-methoxyphenylacetamide",,70693-57-1,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(=O)NC1=CC(=C(C=C1)OC)N(CCOC(=O)C)CC2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/116812,PubChem,COc1ccc(NC(C)=O)cc1N(CCOC(C)=O)Cc1ccccc1,Test,1,2702,training
-"EU_REACH:
-2,6-bis(1,1-dimethylethyl)-4-(phenylenemethylene)cyclohexa-2,5-dien-1-one",,7078-98-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7987/7/4/2/?documentUUID=7bc25222-987c-4c4f-a58c-0df3d6f130a1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1=CC(=CC2=CC=CC=C2)C=C(C1=O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/160881,PubChem,CC(C)(C)C1=CC(=Cc2ccccc2)C=C(C(C)(C)C)C1=O,Train,1,2702,training
-"EU_REACH:
-2-hydroxynaphthalene-1-carbaldehyde",,708-06-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16591/7/4/2/?documentUUID=4939be3a-81ee-4596-bca5-81450614e306,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C=CC(=C2C=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/12819,PubChem,O=Cc1c(O)ccc2ccccc12,Train,1,2702,training
-"EU_REACH:
-2-ethylhexyl (1,1-dimethylpropylperoxy)formate",,70833-40-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11043/7/4/2/?documentUUID=c4912599-f425-481a-a13f-4f890346af16,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)OOC(C)(C)CC,https://pubchem.ncbi.nlm.nih.gov/compound/116706,PubChem,CCCCC(CC)COC(=O)OOC(C)(C)CC,Train,1,2702,training
-"EU_CLP:
-ethyl 2-cyanoacrylate",,7085-85-0,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCOC(=O)C(=C)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/81530,PubChem,C=C(C#N)C(=O)OCC,Test,1,2702,training
-"EU_REACH:
-diisotridecyl phosphonate",,70955-74-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23633/7/4/2/?documentUUID=054995e0-65c9-42f4-9cfb-ae8e6a684b77,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCCCCCCO[P+](=O)OCCCCCCCCCCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6335864,PubChem,CC(C)CCCCCCCCCCO[P+](=O)OCCCCCCCCCCC(C)C,Train,1,2702,training
-"EU_REACH:
-bis(2-methylpropyl) cyclohexane-1,2-dicarboxylate",,70969-58-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10446/7/4/2/?documentUUID=64c8dc3c-b391-4e53-ab8a-8d621ef56176,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)COC(=O)C1CCCCC1C(=O)OCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/116722,PubChem,CC(C)COC(=O)C1CCCCC1C(=O)OCC(C)C,Test,1,2702,training
-"EU_REACH:
-5-amino-2-chloro-N-(2,4-dimethylphenyl)benzene-1-sulfonamide",,71215-81-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26515/7/4/2/?documentUUID=487f71eb-3b9b-4db2-9d8a-f2f8de3ca88f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)NS(=O)(=O)C2=C(C=CC(=C2)N)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/117071,PubChem,Cc1ccc(NS(=O)(=O)c2cc(N)ccc2Cl)c(C)c1,Train,1,2702,training
-"JP_CHRIP:
-1-Butanol
-
-NZ_CCID:
-1-Butanol
-
-US_HSDB:
-N-BUTYL ALCOHOL","JP_CHRIP:
-butan-1-ol
-Butyl alcohol
-n-Butanol
-n-Butyl alcohol
-Propyl carbinol
-
-NZ_CCID:
-Butyl alcohol, Butyl hydroxide, Methylolpropane, Propyl carbinol, Propylcarbinol, n-Butan-1-ol, n-Butyl alcohol, n-butanol",71-36-3,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-2017e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E70DF4D8-1672-4F5D-ACB6-88AA9CB0D5F3
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/48","JP_CHRIP:
-It is described in SIDS (2005), EHC 65 (1987), PATTY (6th, 2012), and DFGOT vol. 19 (2003) that moderate irritation was observed in a 24-hour patch test with rabbits. It is described in ACGIH (7th, 2001), PATTY (6th, 2012) that dermatitis was found in occupational exposure. Furthermore, this substance is classified in ""Xi; R37/38-41"" in EU DSD classification and ""Skin Irrit. 2 H315"" in EU CLP classification. It was classified in Category 2 based on the above information.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Moderate
-REFERENCE SOURCE: Prehled Prumyslove Toxikologie; Organicke Latky, Marhold, J., Prague, Cechoslovakia, Avicenum, 1986 (-,193,1986).
-[RTECS]
-R-PHRASE: R 37/ 38 Irritating to respiratory system and skin. [IUCLID 2000]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Severe irritation
-REFERENCE SOURCE: IPCS INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY Health and Safety Guide No. 3 1-BUTANOL HEALTH AND SAFETY GUIDE 1987 INCHEM]. Butanols - four isomers (EHC 65, 1987). [INCHEM]
-REMARKS: In humans it causes an unusual form of keratitis.
-R-PHRASE: R 41 Risk of serious damage to eyes. [IUCLID 2000]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,CCCCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.374D,J-GLOBAL,CCCCO,Train,1,2702,training
-"JP_CHRIP:
-1-Pentanol
-
-NZ_CCID:
-1-Pentanol","JP_CHRIP:
-n-Amyl alcohol
-n-Butyl carbinol
-n-Pentyl alcohol
-pentan-1-ol
-
-NZ_CCID:
-Amyl alcohol, Butyl carbinol, n-Pentanol, n-Pentyl alcohol",71-41-0,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0045e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/665B00FF-D10F-4BA6-96EE-5C7408BAB870","JP_CHRIP:
-Based on a report that severe irritation was observed after a 24-hour closed application to rabbits (PATTY (5th, 2001)) and EU classification as Xi; R37/38 (EU-Annex I (access on May 2009)), the substance was classified into Category 2. As relevant information, there are reports ""irritating for rabbits"" (IUCLID (2000)) and ""not irritating after 4-hour closed application to rabbits"" (IUCLID (2000)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Irritating
-REFERENCE SOURCE: BASF AG Ludwigshafen (265) BASF AG, Abteilung Toxikologie, unveroeffentlichte
-Untersuchung (XXIII/46), 25.07.1973 [IUCLID 2000]
-REMARK: EC Classification: Irritating
-
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Irritating
-REFERENCE SOURCE: BASF AG Ludwigshafen
-(278) Walberg, J.: Toxicology Letters 18, 49-55 (1983). [IUCLID 2000]",,"JP_CHRIP, NZ_CCID",2,CCCCCO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.423K,J-GLOBAL,CCCCCO,Train,1,2702,training
-"NZ_CCID:
-Methanesulphonic anhydride",,7143-01-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/14255CAB-17C7-483C-8B2E-C16777DD8F20,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CS(=O)(=O)OS(=O)(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/81560,PubChem,CS(=O)(=O)OS(C)(=O)=O,Train,1,2702,training
-"NZ_CCID:
-4,9-Diazadodecamethylenediamine",,71-44-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/39A622A0-F2B9-4127-A990-6B7F19BCC5FA,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C(CCNCCCN)CNCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/1103,PubChem,NCCCNCCCCNCCCN,Train,1,2702,training
-"NZ_CCID:
-2-Bromobenzoyl chloride",,7154-66-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AD9D1A2C-9FC4-4448-9475-53FA4571D937,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C(C(=C1)C(=O)Cl)Br,https://pubchem.ncbi.nlm.nih.gov/compound/23542,PubChem,O=C(Cl)c1ccccc1Br,Train,1,2702,training
-"JP_CHRIP:
-1,1,1-Trichloroethane
-
-NZ_CCID:
-Ethane, 1,1,1-trichloro-","JP_CHRIP:
-alpha-Trichloroethane
-ethane, 1,1,1-trichloro-
-Methyl chloroform
-Methyltrichloromethane
-
-NZ_CCID:
-1,1,1-TCE, 1,1,1-Trichloroethane, Methyl chloroform, Methyltrichloromethane, R140a, alpha-trichloroethane",71-55-6,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2029.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7ECAD28D-849B-40D4-98B1-0A10E055F525","JP_CHRIP:
-【分類根拠】
-（１）～（３）より、区分2とした。
-
-【根拠データ】
-（１）本物質への経皮ばく露による局所影響は、ばく露時間の増加とともに軽度刺激から化学火傷まで増加するが、刺激性影響には回復性がみられる（SIAR (2006)）。
-（２）ウサギを用いた皮膚刺激性試験（OECD TG 404、半閉塞、4時間適用）の結果、皮膚刺激性であったとの報告がある（SIAR (2009)、EHC 136 (1990)）。
-（３）ウサギ（n=3）を用いた皮膚刺激性試験（OECD TG 404相当、半閉塞、4時間適用、16日観察）において、16日後まで紅斑は回復せず（16日後の紅斑スコアの平均：0.3）、一次刺激指数（PII���は5.2であった（紅斑・痂皮スコア：4/4/3、浮腫スコア：2/1.3/1.3）との報告がある（REACH登録情報 (Accessed August 2021)）。
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit/ Guinea pig
-RESULT: Slight to moderate skin irritant.
-REFERENCE SOURCE: [ATSDR]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Mild
-Eye Irritation
-REFERENCE SOURCE: [ATSDR]",Provided,"JP_CHRIP, NZ_CCID",2,CC(Cl)(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.376K,J-GLOBAL,CC(Cl)(Cl)Cl,Train,1,2702,training
-"EU_REACH:
-3-(oxiran-2-ylmethoxy)-N,N-bis(oxiran-2-ylmethyl)aniline",,71604-74-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15967/7/4/2/?documentUUID=2d51ec49-d096-4e16-ab84-f174ee20678a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C(O1)CN(CC2CO2)C3=CC(=CC=C3)OCC4CO4,https://pubchem.ncbi.nlm.nih.gov/compound/3018173,PubChem,c1cc(OCC2CO2)cc(N(CC2CO2)CC2CO2)c1,Test,1,2702,training
-"EU_REACH:
-isopentyl p-methoxycinnamate",,71617-10-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12224/7/4/2/?documentUUID=75fe7fe4-035b-4ad6-a247-e8fffaff4897,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCOC(=O)/C=C/C1=CC=C(C=C1)OC,https://pubchem.ncbi.nlm.nih.gov/compound/1549789,PubChem,COc1ccc(/C=C/C(=O)OCCC(C)C)cc1,Train,1,2702,training
-"NZ_CCID:
-Ethyldicyclohexylamine","NZ_CCID:
-Dicyclohexylamine, N-ethyl-",7175-49-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/394CE693-DE79-437B-8330-F3244EFEA2A6,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCN(C1CCCCC1)C2CCCCC2,https://pubchem.ncbi.nlm.nih.gov/compound/23563,PubChem,CCN(C1CCCCC1)C1CCCCC1,Train,1,2702,training
-"EU_REACH:
-6-(3-methyloctanamido)hexanoic acid",,71902-23-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11335/7/4/2/?documentUUID=82d1bb14-43b6-42f2-a56d-b2cbda67903d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCC(=O)NCCCCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/166214,PubChem,CC(C)CCCCCC(=O)NCCCCCC(=O)O,Train,1,2702,training
-"EU_REACH:
-bis(oxiran-2-ylmethyl) phthalate",,7195-45-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26593/7/4/2/?documentUUID=90a279a7-a025-46d5-99f6-a01044dd82d1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C(O1)COC(=O)C2=CC=CC=C2C(=O)OCC3CO3,https://pubchem.ncbi.nlm.nih.gov/compound/62629,PubChem,O=C(OCC1CO1)c1ccccc1C(=O)OCC1CO1,Train,1,2702,training
-"EU_CLP:
-N-(dichlorofluoromethylthio)phthalimide; N-(fluorodichloromethylthio)phthalimide",,719-96-0,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC=C2C(=C1)C(=O)N(C2=O)SC(F)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/69755,PubChem,O=C1c2ccccc2C(=O)N1SC(F)(Cl)Cl,Test,1,2702,training
-"EU_REACH:
-2-(2-phenylphenoxy)ethyl prop-2-enoate",,72009-86-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21708/7/4/2/?documentUUID=fd16dcf8-b564-4604-af40-30b88befa053,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CC(=O)OCCOC1=CC=CC=C1C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/23290047,PubChem,C=CC(=O)OCCOc1ccccc1-c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-Sulphathiazole","NZ_CCID:
-Sulfathiazole",72-14-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/554493F7-47EF-4F45-A7FA-2EF63F50A594,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Sigma-aldrich msds]
-Eye Irritation
-R PHRASE: R 36 [Sigma-aldrich msds]",,NZ_CCID,1,C1=CC(=CC=C1N)S(=O)(=O)NC2=NC=CS2,https://pubchem.ncbi.nlm.nih.gov/compound/5340,PubChem,Nc1ccc(S(=O)(=O)Nc2nccs2)cc1,Train,1,2702,training
-"NZ_CCID:
-Sulfamethoxazole",,723-46-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7763C5C6-2224-405C-BBC2-2B8E23A15462,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [sigma-aldrich msds]
-Eye Irritation
-R PHRASE: R 36 [sigma-aldrich msds]",,NZ_CCID,1,CC1=CC(=NO1)NS(=O)(=O)C2=CC=C(C=C2)N,https://pubchem.ncbi.nlm.nih.gov/compound/5329,PubChem,Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1,Train,1,2702,training
-"EU_REACH:
-β,β-carotene",,7235-40-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25238/7/4/2/?documentUUID=b3e6edfd-930a-4f78-9d8d-4bdaa0de3b64,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C2=C(CCCC2(C)C)C)\C)\C)/C)/C,https://pubchem.ncbi.nlm.nih.gov/compound/5280489,PubChem,CC1=C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)C(C)(C)CCC1,Train,1,2702,training
-"EU_REACH:
-2-dodecylhexadecan-1-ol",,72388-18-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12621/7/4/2/?documentUUID=517ae07f-4225-4c47-94a7-d201ca152e1f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCCCC(CCCCCCCCCCCC)CO,https://pubchem.ncbi.nlm.nih.gov/compound/3018340,PubChem,CCCCCCCCCCCCCCC(CO)CCCCCCCCCCCC,Train,1,2702,training
-"EU_CLP:
-2-methylpropyl 2-hydroxy-2-methylbut-3-enoate",,72531-53-4,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C)COC(=O)C(C)(C=C)O,https://pubchem.ncbi.nlm.nih.gov/compound/2827086,PubChem,C=CC(C)(O)C(=O)OCC(C)C,Test,1,2702,training
-"NZ_CCID:
-2-Pyridinol",,72762-00-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7360FA6E-7538-4604-8559-D4ED1AC0D7F6,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=O)NC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/8871,PubChem,O=c1cccc[nH]1,Train,1,2702,training
-"EU_REACH:
-unnamed [72901-31-6]",,72901-31-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26032/7/4/2/?documentUUID=00ef2988-dec3-49e5-b113-48e252c3cfa1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCC/C=C/CCCCCCCCNC(=O)CCCCCCC/C=C\CCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/6442040,PubChem,CCCCCCCC/C=C\CCCCCCCC(=O)NCCCCCCCC/C=C/CCCCCCCC,Train,1,2702,training
-"AU_HCIS:
-Ethanol, 2-[2-[2-[2-(4-nonylphenoxy)ethoxy]ethoxy]ethoxy]-
-
-JP_CHRIP:
-11-(4-Nonylphenoxy)-3,6,9-trioxaundecan-1-ol (Nonoxynol-4 (p-form))","JP_CHRIP:
-11-(4-Nonylphenoxy)-3,6,9-trioxaundecanol
-2-(2-{2-[2-(4-Nonylphenoxy)ethoxy]ethoxy}ethoxy)ethanol
-Ethanol, 2-[2-[2-[2-(4-nonylphenoxy)ethoxy]ethoxy]ethoxy]-",7311-27-5,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6657
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-meti-0007e.html","JP_CHRIP:
-[Rationale for the Classification]
-Based on (1) and (2), it was classified in Category 2. Besides, although there are data (3) and (4) which showed this substance is not irritating to the skin, the reliability of these data is compared with the reliability of data (1) and (2), resulting in the judgment above based on the weight of evidence.
-
-[Evidence Data]
-(1) There is a report that as a result of repeated occlusive applications (3 times/week for 3 weeks, induction phase) of a 10% solution of Nonoxynol-4 (p-isomer) (in mineral oil) for 48 hours to the dorsal skin of 111 humans (10 men and 101 women), very slight to moderate erythema was observed in 36/111 (32.4%) (CIR Expert Panel (2016), J. Am. Coll. Toxicol., 2, 35-60 (1983), Canada PS Assessment report (2001)).
-(2) There is a report that in a skin irritation test with rabbits, as a result of an occlusive application of nonoxynol-4 (p-isomer) for 24 hours, in the 0.5 mL application group (n = 6) well-defined to severe erythema and slight to severe edema were observed in all the animals, and the primary irritation index (PII) was 5.58 based on the average score of erythema and edema at 24, 72 hours after the start of exposure (CIR Expert Panel (2016), J. Am. Coll. Toxicol., 2, 35-60 (1983)).
-(3) There is a report that in an irritation test in which undiluted Nonoxynol-4 (p-isomer) was applied to the dorsal skin of humans (each 25 men and women) for 48 hours at the first time and then 14 times every 24 hours repeatedly, no irritation was observed (CIR Expert Panel (2016), J. Am. Coll. Toxicol., 2, 35-60 (1983)).
-(4) There is a report that in a skin irritation test with rabbits, as a result of an occlusive application of nonoxynol-4 (p-isomer) for 24 hours, in the 0.01 mL application group (n = 5), no irritation was observed (CIR Expert Panel (2016), J. Am. Coll. Toxicol., 2, 35-60 (1983)).",,"AU_HCIS, JP_CHRIP",2,CCCCCCCCCc1ccc(OCCOCCOCCOCCO)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.143F,J-GLOBAL,CCCCCCCCCc1ccc(OCCOCCOCCOCCO)cc1,Train,1,2702,training
-"AU_HCIS:
-Oxirane, tetradecyl-",,7320-37-8,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5459,,,AU_HCIS,1,CCCCCCCCCCCCCCC1CO1,https://pubchem.ncbi.nlm.nih.gov/compound/23741,PubChem,CCCCCCCCCCCCCCC1CO1,Train,1,2702,training
-"EU_REACH:
-4-isobutyl-2-methylbenzaldehyde",,73206-60-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17395/7/4/2/?documentUUID=6f8fb838-f6d9-4282-ab1d-f024ec72cf4d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=CC(=C1)CC(C)C)C=O,https://pubchem.ncbi.nlm.nih.gov/compound/12580548,PubChem,Cc1cc(CC(C)C)ccc1C=O,Test,1,2702,training
-"JP_CHRIP:
-O,O-dimethyl phthalimidomethyl S-phosphorodithioate; Phosmet","JP_CHRIP:
-O,O-Dimethyl phosphorodithioate S-ester with N-(mercaptomethyl) phthalimide
-O,O-Dimethyl S-phthalimidomethyl phosphorodithioate
-Phosmet
-Phosphorodithioic acid, S-((1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl) O,O-dimethyl ester
-Phosphorodithioic acid, S-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl] O,O-dimethyl ester",732-11-6,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2071e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified as ""Not classified"" from (1) - (4). Because new data (1) - (4) were obtained, the classification result was changed.
-
-[Evidence Data]
-(1) In a skin irritation test with rabbits similar to OECD TG 404, no irritation reactions were seen at 24 hours after application (CLH Report (2015), RAC Background Document (2016)).
-(2) In a skin irritation test with rabbits according to EPA OPPTS 870.2500, it was not irritating (EPA Pesticides RED (2006)).
-(3) This substance was not irritating in a skin irritation test with rabbits (Draize test) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012)).
-(4) This substance was not a skin irritant (HSDB (Access on May 2020)).",Provided,JP_CHRIP,1,COP(=S)(OC)SCN1C(=O)c2ccccc2C1=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.108C,J-GLOBAL,COP(=S)(OC)SCN1C(=O)c2ccccc2C1=O,Train,1,2702,training
-"EU_REACH:
-2,4,6-tri-tert-butylphenol",,732-26-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5641/7/4/2/?documentUUID=ee760c18-d3b0-4681-aeba-18b8a3bd4285,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/12902,PubChem,CC(C)(C)c1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1,Train,1,2702,training
-"NZ_CCID:
-2-Propenoic acid, 2-(2-ethoxyethoxy)ethyl ester",,7328-17-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/01534F5B-6F8A-4AC5-B11E-1E72D91C7BB9,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,CCOCCOCCOC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/81766,PubChem,C=CC(=O)OCCOCCOCC,Train,1,2702,training
-"EU_REACH:
-2-(2-butoxyethoxy)ethyl 2-methylprop-2-enoate",,7328-22-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10356/7/4/2/?documentUUID=d47dd6f7-ab21-446c-b0e3-337dbe6e7fcd,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOCCOCCOC(=O)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/81768,PubChem,C=C(C)C(=O)OCCOCCOCCCC,Train,1,2702,training
-"NZ_CCID:
-2,2-Dimethylpropylenediamine","NZ_CCID:
-2,2-dimethyl-1,3-propanediamine",7328-91-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/68E5907B-6E3E-49F3-BBB2-679D6143CC16,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(C)(CN)CN,https://pubchem.ncbi.nlm.nih.gov/compound/81770,PubChem,CC(C)(CN)CN,Train,1,2702,training
-"ChemSkin:
-Benzenethiol, 5-(1,1-dimethylethyl)-2-methyl #",,7340-90-1,Cat 2,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,CC1=C(C=C(C=C1)C(C)(C)C)S,https://pubchem.ncbi.nlm.nih.gov/compound/596868,PubChem,Cc1ccc(C(C)(C)C)cc1S,Test,1,2702,training
-"EU_REACH:
-1,1'-ethane-1,2-diylbis(4-nitrobenzene)",,736-30-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7759/7/4/2/?documentUUID=66c2c937-84ad-483f-932d-257f238d89a2,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1CCC2=CC=C(C=C2)[N+](=O)[O-])[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/69776,PubChem,O=[N+]([O-])c1ccc(CCc2ccc([N+](=O)[O-])cc2)cc1,Train,1,2702,training
-"EU_REACH:
-2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid",,7365-45-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13322/7/4/2/?documentUUID=0fe26b68-bc32-4983-a68d-dabde051132d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CN(CCN1CCO)CCS(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/23831,PubChem,O=S(=O)(O)CCN1CCN(CCO)CC1,Train,1,2702,training
-"EU_REACH:
-1,1'-(1,3-Phenylenedicarbonyl)diazepan-2-one",,7381-13-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17347/7/4/2/?documentUUID=2729ff26-969f-4c60-8e48-a3d1ab4acb86,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CCC(=O)N(CC1)C(=O)C2=CC(=CC=C2)C(=O)N3CCCCCC3=O,https://pubchem.ncbi.nlm.nih.gov/compound/81857,PubChem,O=C1CCCCCN1C(=O)c1cccc(C(=O)N2CCCCCC2=O)c1,Train,1,2702,training
-"AU_HCIS:
-Oxirane, hexadecyl-",,7390-81-0,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5460,,,AU_HCIS,1,CCCCCCCCCCCCCCCCC1CO1,https://pubchem.ncbi.nlm.nih.gov/compound/23872,PubChem,CCCCCCCCCCCCCCCCC1CO1,Train,1,2702,training
-"EU_REACH:
-2-(2H-1,2,3-benzotriazol-2-yl)-6-(2-phenylpropan-2-yl)-4-(2,4,4-trimethylpentan-2-yl)phenol",,73936-91-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15623/7/4/2/?documentUUID=c5c6043b-c3f8-4222-91e6-439ef065e527,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)CC(C)(C)C1=CC(=C(C(=C1)N2N=C3C=CC=CC3=N2)O)C(C)(C)C4=CC=CC=C4,https://pubchem.ncbi.nlm.nih.gov/compound/9803353,PubChem,CC(C)(C)CC(C)(C)c1cc(-n2nc3ccccc3n2)c(O)c(C(C)(C)c2ccccc2)c1,Train,1,2702,training
-"EU_REACH:
-2,2-bis[(decanoyloxy)methyl]butyl decanoate; 2,2-bis[(octanoyloxy)methyl]butyl decanoate; 2-[(decanoyloxy)methyl]-2-[(octanoyloxy)methyl]butyl decanoate",,73947-34-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20848/7/4/2/?documentUUID=58669a32-4bf5-4f40-9162-17e9cd99a16e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCC(=O)OCC(CC)(COC(=O)CCCCCCC)COC(=O)CCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/22833312,PubChem,CCCCCCCCCC(=O)OCC(CC)(COC(=O)CCCCCCC)COC(=O)CCCCCCC,Train,1,2702,training
-"NZ_CCID:
-1-Decanamine, N-decyl-N-methyl-",,7396-58-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C204482D-7507-48BC-B8C4-5296BA30E615,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCCCCCCCCCN(C)CCCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/81880,PubChem,CCCCCCCCCCN(C)CCCCCCCCCC,Train,1,2702,training
-"JP_CHRIP:
-Butyl hydroxyacetate",,7397-62-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0041e.html,"JP_CHRIP:
-On the basis of a ""not irritating"" result in a test using rabbits (OECD TG 404; GLP) (IUCLID (2000)), it was classified as ""Not classified.""",Provided,JP_CHRIP,1,CCCCOC(=O)CO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J39.924H,J-GLOBAL,CCCCOC(=O)CO,Train,1,2702,training
-"US_HSDB:
-P-CHLOROBENZOIC ACID",,74-11-3,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/6019,,,US_HSDB,1,C1=CC(=CC=C1C(=O)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/6318,PubChem,O=C(O)c1ccc(Cl)cc1,Train,1,2702,training
-"EU_REACH:
-4-methoxy-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)-2-nitrophenyl]benzamide",,74149-73-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6755/7/4/2/?documentUUID=44f8f04c-be6a-432c-b21e-e83917c39f81,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1CC(=O)NN=C1C2=CC(=C(C=C2)NC(=O)C3=CC=C(C=C3)OC)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/13850880,PubChem,COc1ccc(C(=O)Nc2ccc(C3=NNC(=O)CC3C)cc2[N+](=O)[O-])cc1,Train,1,2702,training
-"EU_REACH:
-N-[2-amino-4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl]-4-methoxybenzamide",,74149-74-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6756/7/4/2/?documentUUID=e1e17d46-d6ed-4b67-9c4c-0241e5daf8ca,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1CC(=O)NN=C1C2=CC(=C(C=C2)NC(=O)C3=CC=C(C=C3)OC)N,https://pubchem.ncbi.nlm.nih.gov/compound/13850881,PubChem,COc1ccc(C(=O)Nc2ccc(C3=NNC(=O)CC3C)cc2N)cc1,Train,1,2702,training
-"JP_CHRIP:
-Sulfometuron Methyl","JP_CHRIP:
-Methyl 2-(4,6-dimethyl-2-pyrimidinylaminocarbonylaminosulfonyl)benzoate",74222-97-2,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2053e.html,"JP_CHRIP:
-[Rationale for the Classification]
-Based on (1), it was classified in Category 2.
-
-[Evidence Data]
-(1) Slight irritation (irritation index 1.3-2.9 (maximum 5)) was reported in a skin irritation test with rabbits (ACGIH (7th, 2019)).
-
-[Reference Data, etc.]
-(2) No irritation was observed in a skin irritation test with rabbits compliant with EPA OPPTS 870.2500 (EPA Pesticide (2005)).
-(3) In a skin irritation test with guinea pigs on a 50% or 5% suspension in dimethyl phthalate, it was mildly irritating at 50% and not irritating at 5% (ACGIH (7th, 2019)).
-(4) This substance shows minimal eye irritation and skin irritation, but is not a dermal irritant or a dermal sensitizer (HSDB (Access on July 2019)).",,JP_CHRIP,1,COC(=O)c1ccccc1S(=O)(=O)NC(=O)Nc1nc(C)cc(C)n1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J21.691G,J-GLOBAL,COC(=O)c1ccccc1S(=O)(=O)NC(=O)Nc1nc(C)cc(C)n1,Train,1,2702,training
-"EU_REACH:
-4-amino-N-(4-carbamoylphenyl)benzamide",,74441-06-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11122/7/4/2/?documentUUID=4717829d-a4cc-4baf-8e68-8154d7f60913,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1C(=O)NC2=CC=C(C=C2)C(=O)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/3018508,PubChem,NC(=O)c1ccc(NC(=O)c2ccc(N)cc2)cc1,Train,1,2702,training
-"EU_REACH:
-3,7,11,15-tetramethylhexadecane-1,2,3-triol
-
-NZ_CCID:
-Phytantriol",,74563-64-7,Cat 2,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25084/7/4/2/?documentUUID=1eed4381-2fc8-491c-b319-35387422af09
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7B425D2E-AB4F-4F6E-A34A-21F937E41EF6","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-NZ_CCID:
-Skin Irritation
-REMARK: Confidential information supplied by registrant.",Provided,"EU_REACH, NZ_CCID",2,CC(C)CCCC(C)CCCC(C)CCCC(C)(C(CO)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/3018525,PubChem,CC(C)CCCC(C)CCCC(C)CCCC(C)(O)C(O)CO,Train,1,2702,training
-"NZ_CCID:
-9,12-Octadecadienoyl chloride, (9Z,12Z)-",,7459-33-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/26F9D34E-6562-44C4-AE0B-46698BE74678,,,NZ_CCID,1,CCCCCC=CCC=CCCCCCCCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/98987,PubChem,CCCCCC=CCC=CCCCCCCCC(=O)Cl,Train,1,2702,training
-"EU_REACH:
-(5Z)-5-(phenylmethylidene)imidazolidine-2,4-dione",,74805-60-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5652/7/4/2/?documentUUID=cf88cc61-f25a-4f24-baec-31e2e7684d66,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)/C=C\2/C(=O)NC(=O)N2,https://pubchem.ncbi.nlm.nih.gov/compound/5706042,PubChem,O=C1NC(=O)/C(=C/c2ccccc2)N1,Train,1,2702,training
-"EU_REACH:
-2-({9-azatricyclo[9.4.0.0³,⁸]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-10-yl}methyl)-2,3-dihydro-1H-isoindole-1,3-dione",,74860-00-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5205/7/4/2/?documentUUID=9d8ff5f7-9e46-4450-b4e1-58db618ae204,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C2=CC=CC=C2C(=NC3=CC=CC=C31)CN4C(=O)C5=CC=CC=C5C4=O,https://pubchem.ncbi.nlm.nih.gov/compound/11142718,PubChem,O=C1c2ccccc2C(=O)N1CC1=Nc2ccccc2Cc2ccccc21,Train,1,2702,training
-"ChemSkin:
-Diisopropyl sebacate",,7491-02-3,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,CC(C)OC(=O)CCCCCCCCC(=O)OC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/24096,PubChem,CC(C)OC(=O)CCCCCCCCC(=O)OC(C)C,Test,1,2702,training
-"ChemSkin:
-Allyl phenoxyacetate #",,7493-74-5,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
-Experimental study (OECD TG 404)",Provided,ChemSkin,1,C=CCOC(=O)COC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/24117,PubChem,C=CCOC(=O)COc1ccccc1,Test,1,2702,training
-"JP_CHRIP:
-Dibromomethane","JP_CHRIP:
-Methylene bromide
-Methylene dibromide",74-95-3,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2066e.html,"JP_CHRIP:
-Based on the description that it showed moderate to severe irritation in skin irritation tests with rabbits (SIAP (2013)) and the description that it showed mild irritation (PATTY (6th, 2012)), it was classified in Category 2. Based on the information obtained in this investigation, the category was revised.",,JP_CHRIP,1,BrCBr,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.433H,J-GLOBAL,BrCBr,Train,1,2702,training
-"JP_CHRIP:
-Chloroethane","JP_CHRIP:
-Ethyl chloride
-Chloroethane
-Ethyl_chloride
-Monochloroethane",75-00-3,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0085e.html,"JP_CHRIP:
-There is a report that edema was observed in the subcutaneous tissues as a result of an application of this substance to rats (SIDS (2007)). In addition, there is a report of skin irritation in humans exposed to the vapor of this substance (SIDS (2007), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)). From the above, it was classified in Category 2.",,JP_CHRIP,1,CCCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.386H,J-GLOBAL,CCCl,Train,1,2702,training
-"EU_REACH:
-2-ethylhexyl 2-{[1,1'-biphenyl]-4-carbonyl}benzoate",,75005-95-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31361/7/4/2/?documentUUID=070fb787-b3a5-4b50-9849-487140409031,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)C2=CC=C(C=C2)C3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/135606,PubChem,CCCCC(CC)COC(=O)c1ccccc1C(=O)c1ccc(-c2ccccc2)cc1,Train,1,2702,training
-"JP_CHRIP:
-Vinyl chloride","JP_CHRIP:
-Chloroethene
-Chloroethylene
-Chloroethylene;Chloroethene;Vinyl chloride
-VCM
-Vinyl chloride
-Vinyl chloride monomer
-Vinyl_chloride",75-01-4,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2076e.html,"JP_CHRIP:
-Erythema and second-degree burns were reported in a worker after accidental exposure to liquid vinyl chloride. He recovered without sequelae (EHC 215 (1999)). Based on the report, the substance was classified into Category 2.",,JP_CHRIP,1,ClC=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.387F,J-GLOBAL,C=CCl,Train,1,2702,training
-"NZ_CCID:
-Iodoethane","NZ_CCID:
-ethyl iodide",75-03-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7CD0B546-B0B9-450E-AC30-4B4878BD63F1,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCI,https://pubchem.ncbi.nlm.nih.gov/compound/6340,PubChem,CCI,Train,1,2702,training
-"JP_CHRIP:
-Ethanamine
-
-NZ_CCID:
-Ethanamine, anhydrous (ethylamine)","JP_CHRIP:
-Aminoethane
-Ethylamine
-
-NZ_CCID:
-1-Aminoethane, Aminoethane, Ethanamine, Ethylamine, Monoethylamine, R631",75-04-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0657e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/815E0EDF-D7A8-4AFB-AE73-7F98E7AFC76B","JP_CHRIP:
-Based on the descriptions the necrosis of skin and burn (ACGIH (2001) and PATTY (5th, 2001)), and corrosion (IUCLID (2000)) in animal experiments, it was classified as Category 1A-1C.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Guinea pig
-RESULT: Severe
-Skin Irritation with extensive necrosis and deep scarring from 0.1 mf of 70% solution held in guinea pig skin for 24 hr and prompt necrotic skin burns from 70% dropped on guinea pig skin.
-REFERENCE SOURCE: [Clayton, G.D., F.E. Clayton (eds.) Pattys Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994. 1116] [HSDB]
-Eye Irritation
-SPECIES:
-RESULT: Severe
-REFERENCE SOURCE: [Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT06817) (4/25/1958)] [Eye2]: EYE - STANDARD DRAIZE TEST [RTECS]",,"JP_CHRIP, NZ_CCID",2,CCN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.437K,J-GLOBAL,CCN,Train,1,2702,training
-"AU_HCIS:
-dichloromethane
-
-JP_CHRIP:
-Dichloromethane
-
-KR_NCIS:
-Dichloromethane
-
-NZ_CCID:
-Methane, dichloro-
-
-US_HSDB:
-DICHLOROMETHANE","AU_HCIS:
-methylene chloride
-Methane, dichloro-
-
-JP_CHRIP:
-Methylene chloride
-DCM
-Dichloromethane (Methylene chloride)
-Dichloromethane; Methylene dichloride
-methane, dichloro-
-Methylene chloride
-Methylene dichloride
-
-KR_NCIS:
-Methylene dichloride; Methylene chloride
-
-NZ_CCID:
-DCM, Dichloromethane, Metaclen, Methylene bichloride, Methylene chloride, Narkotil, R30, Solaesthin, Solmethine",75-09-2,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1282
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2064e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/67005C84-2541-4E8A-8993-53F34149048C
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/66","JP_CHRIP:
-Based on multiple results showing strong or moderate skin irritation in skin irritation tests with rabbits (DFGOT Vol. 1 (2016) (Access on May 2017), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)), it was classified in Category 2.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Moderate irritant
-REFERENCE SOURCE: Van Beek, 1990 EHC 164. 1996 [INCHEM]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Moderate to severe irritant
-REFERENCE SOURCE: Duprat et al. (1976) and Ballantyne et al. (1976) EHC 164, 1996 [INCHEM]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,ClCCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.389B,J-GLOBAL,ClCCl,Train,1,2702,training
-"NZ_CCID:
-Methylene iodide","NZ_CCID:
-Methane, diiodo-",75-11-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2ED46542-E7BC-4839-AB1F-79D6A3F6ADFE,"NZ_CCID:
-Skin Irritation
-REMARK: Classification based on company data
-Eye Irritation
-REMARK: Classification based on company data",,NZ_CCID,1,C(I)I,https://pubchem.ncbi.nlm.nih.gov/compound/6346,PubChem,ICI,Train,1,2702,training
-"EU_CLP:
-ethylene oxide;
-oxirane",,75-21-8,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1CO1,https://pubchem.ncbi.nlm.nih.gov/compound/6354,PubChem,C1CO1,Test,1,2702,training
-"AU_HCIS:
-2-aminopropane
-
-JP_CHRIP:
-Isopropylamine
-
-NZ_CCID:
-2-Propanamine
-
-US_HSDB:
-Isopropylamine","AU_HCIS:
-isopropylamine
-2-Propanamine
-
-JP_CHRIP:
-1-methylethylamine
-2-Aminopropane
-2-Propaneamine
-Isopropylamine
-
-NZ_CCID:
-1-Methylethylamine, 2-Aminopropane, 2-Propaneamine, 2-Propylamine, Isopropylamine, Monoisopropylamine, sec-Propylamine",75-31-0,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=217
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2120e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6F078C37-326C-4B79-9DE0-3BBFE4A01267
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/804","JP_CHRIP:
-Based on the description that in a skin irritation test with rabbits (equivalent to OECD TG 404), necrosis, followed by eschar, occurred within 24 hours after 3-minute application of this substance, and a description that corrosion was seen in both of other two tests with rabbits (application time: 1, 5, 15 minutes or 24 hours) (both from SIDS (2016)), this substance was classified in Category 1A. Besides, this substance is classified as ""Skin Irrit. 2, H315"" in EU CLP classification (ECHA CL Inventory (Access on August 2017)). Based on the information obtained in this investigation, the category was changed.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Corrosive
-REFERENCE SOURCE: BASF AG Ludwigshafen (70) TSCAT, OTS0542011, Doc-I.D. 88-920003765, 07-17-85, Monsanto Acgric Co. (Intl. Res. & Develop. Corp.)
-[IUCLID 2000]
-REMARK: EC Classification: Corrosive (causes burns).
-Eye Irritation
-SPECIES: Human
-RESULT: Vapour: mild corneal edema (usually clearing within 3 or 4 hours). Liquid: very severe eye burns, which may cause permanent visual impairment.
-REFERENCE SOURCE: [Peer Reviewed] Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) PublicationNo. 81-123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981. [HSDB]",Provided,"AU_HCIS, JP_CHRIP, NZ_CCID, US_HSDB",4,CC(C)N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.451F,J-GLOBAL,CC(C)N,Train,1,2702,training
-"NZ_CCID:
-2-Propanethiol","NZ_CCID:
-1-Methylethanethiol, 2-Mercaptopropane, 2-Propylmercaptan, Isopropyl mercaptan, Isopropylthiol",75-33-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C98F2556-39CC-4A78-A63A-82F75D2E0AB3,"NZ_CCID:
-Skin Irritation
-SPECIES:
-RESULT: Vapour: Irritating to eyes, nose and throat. Liquid: irritating to skin and eyes.
-REFERENCE SOURCE: U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office, 1984-5.]**PEER REVIEWED** [HSDB]
-
-Eye Irritation
-SPECIES:
-RESULT: Vapour: Irritating to eyes, nose and throat. Liquid: irritating to skin and eyes.
-REFERENCE SOURCE: U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office, 1984-5.]**PEER REVIEWED** [HSDB]",,NZ_CCID,1,CC(C)S,https://pubchem.ncbi.nlm.nih.gov/compound/6364,PubChem,CC(C)S,Train,1,2702,training
-"JP_CHRIP:
-1,1-Dichloroethane","JP_CHRIP:
-Ethane, 1,1-dichloro-
-Ethylidene chloride",75-34-3,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2045e.html,"JP_CHRIP:
-Based on a description that the vapor of this substance was irritating to the skin in humans (PATTY (6th, 2012)), it was classified in Category 2. Besides, slight edema and slight necrosis were observed in repeated exposure in rabbits, and it was reported to be moderately irritating (IUCLID (2000)).",,JP_CHRIP,1,CC(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.452D,J-GLOBAL,CC(Cl)Cl,Train,1,2702,training
-"JP_CHRIP:
-acetyl chloride
-
-NZ_CCID:
-Acetyl chloride
-
-US_HSDB:
-Acetyl chloride","JP_CHRIP:
-Acetic acid chloride
-Acetic chloride
-Ethanoyl chloride
-
-NZ_CCID:
-Acetic acid, chloride, Ethanoyl chloride",75-36-5,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0004e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3AECAFF3-C0BA-47E7-A3A4-944E864DC6F1
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/662","JP_CHRIP:
-Cases of skin burns in humans have been documented (HSDB (2003), SITTING (5th ED 2008)), and the substance is classified into R34 by the EU. In addition, it is rated UN Subsidiary Risks 8 according to UN1717. Thus the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-R-PHRASE: R 34 Irritating to eyes.
-REFERENCE SOURCE: Hoechst AG Frankfurt/Main
-Clariant GmbH Frankfurt am Main. [IUCLID 2000]
-REMARK: EC Classification: Corrosive (causes burns).
-
-Eye Irritation
-SPECIES:
-RESULT: Redness. Pain. Severe deep burns.
-REFERENCE SOURCE: ICSC 0210, Oct 1995
-[INCHEM]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,CC(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.453B,J-GLOBAL,CC(=O)Cl,Train,1,2702,training
-"NZ_CCID:
-6-Octen-1-ol, 3,7-dimethyl-, (S)-",,7540-51-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/75E3206E-D058-4D72-B9A8-5B8C1F0F4030,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]",,NZ_CCID,1,C[C@@H](CCC=C(C)C)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/7793,PubChem,CC(C)=CCC[C@H](C)CCO,Train,1,2702,training
-"NZ_CCID:
-Trimethylvinylsilane",,754-05-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7E634332-F950-4632-B98E-E1B7A51C94A9,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C[Si](C)(C)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/79102,PubChem,C=C[Si](C)(C)C,Train,1,2702,training
-"EU_CLP:
-phosgene; carbonyl chloride",,75-44-5,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C(=O)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/6371,PubChem,O=C(Cl)Cl,Test,1,2702,training
-"JP_CHRIP:
-Dichloro(methy)lsilane
-
-KR_NCIS:
-Silane, dichloromethyl-","JP_CHRIP:
-Dichloromethylsilane
-Monomethyldichlorosilane
-
-KR_NCIS:
-Dichloro(methyl)silane; Dichlorohydridomethylsilicon; Dichloromethylsilane; Methyldichlorosilane; Methylsilicon dichloride",75-54-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0046e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP:
-There is a report that skin reaction was ""severe"" in a Draize test where 2 mg was applied to rabbits for 24-hour (IUCLID (2000)) and ""highly corrosive"" was produced in an animal test (IUCLID (2000)). In addition, there is a report of ""causes severe skin burns for human"" (HSDB (2006)). The substance was classified into Category 1.",,"JP_CHRIP, KR_NCIS",2,C[SiH](Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J44.081G,J-GLOBAL,C[SiH](Cl)Cl,Train,1,2702,training
-"EU_REACH:
-2-methyloxirane",,75-56-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16091/7/4/2/?documentUUID=34c8823d-505b-4d14-ab3d-6aab8298c9f8,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1CO1,https://pubchem.ncbi.nlm.nih.gov/compound/6378,PubChem,CC1CO1,Train,1,2702,training
-"NZ_CCID:
-Cyclohexanamine, N-cyclohexyl-N-methyl-",,7560-83-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/027576ED-75F0-4AA4-9ECB-B0FFBFBBE43C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CN(C1CCCCC1)C2CCCCC2,https://pubchem.ncbi.nlm.nih.gov/compound/24210,PubChem,CN(C1CCCCC1)C1CCCCC1,Train,1,2702,training
-"EU_REACH:
-1,1,1,3,4,4,4-heptafluoro-3-(trifluoromethyl)butan-2-one",,756-12-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31606/7/4/2/?documentUUID=989d47b9-2232-4492-8361-4f8f0714d755,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(=O)(C(C(F)(F)F)(C(F)(F)F)F)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/14175377,PubChem,O=C(C(F)(F)F)C(F)(C(F)(F)F)C(F)(F)F,Train,1,2702,training
-"EU_REACH:
-1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl)pentan-3-one",,756-13-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19473/7/4/2/?documentUUID=db9c868f-5288-4658-a437-4579282d50bc,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(=O)(C(C(F)(F)F)(C(F)(F)F)F)C(C(F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/2782408,PubChem,O=C(C(F)(F)C(F)(F)F)C(F)(C(F)(F)F)C(F)(F)F,Train,1,2702,training
-"NZ_CCID:
-Bromotrichloromethane",,75-62-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/95A18184-C4A0-4950-B353-26BF2E8CF238,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(Cl)(Cl)(Cl)Br,https://pubchem.ncbi.nlm.nih.gov/compound/6383,PubChem,ClC(Cl)(Cl)Br,Train,1,2702,training
-"NZ_CCID:
-2-Propanamine, 2-methyl-","NZ_CCID:
-1,1-Dimethylethanamine, 1,1-Dimethylethylamine, 2-Amino-2-methylpropane, 2-Aminoisobutane, 2-Methyl-2-aminopropane, 2-Methyl-2-propanamine, Erbumine, Trimethylaminomethane, t-Butylamine, tert-Butylamine",75-64-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E180BC1B-115A-4245-9914-88E350ADAEC1,"NZ_CCID:
-Skin Irritation
-UN CLASS: Packing Group II
-Eye Irritation
-R PHRASE: R 35 [Company Data]",,NZ_CCID,1,CC(C)(C)N,https://pubchem.ncbi.nlm.nih.gov/compound/6385,PubChem,CC(C)(C)N,Train,1,2702,training
-"JP_CHRIP:
-tert-Butyl mercaptan","JP_CHRIP:
-Benzenemethanethiol
-tert-Butyl mercaptan",75-66-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-0024e.html,"JP_CHRIP:
-As for a 4-hour application in skin irritation tests (corresponding to OECD TG 404 and OPPTS 870.2500), it is reported that it was mildly irritating (SIDS (2012)) and that it was not irritating (ECHA registration dossier (Access on December 2017)). Also, there are descriptions that mild irritation was observed in the 24-hour application test (SIDS (2012)), and that mild irritation or mild erythema and discoloration at the application site were observed although the application time was unknown (PATTY (6th, 2012)). Therefore, this substance was considered to have mild irritancy and it was classified as ""Not Classified"" (Category 3 in UN GHS classification), to which ""mild irritation"" is considered to correspond in the GHS classification guidance for Japanese government.",Provided,JP_CHRIP,1,CC(C)(C)S,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.161K,J-GLOBAL,CC(C)(C)S,Train,1,2702,training
-"JP_CHRIP:
-methanesulphonic acid
-
-KR_NCIS:
-Methanesulfonic acid
-
-NZ_CCID:
-Methanesulphonic acid","JP_CHRIP:
-Methanesulfonic acid",75-75-2,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0138e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/69F8BEA0-B5E3-4FB8-A93E-7E368E23BB5C","JP_CHRIP:
-Since it is documented that in an irritation test with 1-h exposure to mouse skin, it was corrosive (PATTY (5th, 2001)), and in an irritation test using guinea pigs, it resulted in numerous small lesions resembling acid burns (PATTY (5th, 2001)), the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-REMARK: >1 but <4 hr: Corrosive (PGIII)
-REFERENCE SOURCE: IUCLID Data Set
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Corrosive: risk of serious damage to eyes
-REFERENCE SOURCE: IUCLID Data Set",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,CS(=O)(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.465F,J-GLOBAL,CS(=O)(=O)O,Train,1,2702,training
-"EU_REACH:
-3-[(3-sulfanylpropanoyl)oxy]-2,2-bis({[(3-sulfanylpropanoyl)oxy]methyl})propyl 3-sulfanylpropanoate",,7575-23-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10120/7/4/2/?documentUUID=433dcae7-1400-4bc4-a1cc-26a3c7fd1ed8,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CS)C(=O)OCC(COC(=O)CCS)(COC(=O)CCS)COC(=O)CCS,https://pubchem.ncbi.nlm.nih.gov/compound/82056,PubChem,O=C(CCS)OCC(COC(=O)CCS)(COC(=O)CCS)COC(=O)CCS,Train,1,2702,training
-"EU_REACH:
-tetramethylsilane",,75-76-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14468/7/4/2/?documentUUID=0aeb8566-8767-4249-b76c-989d33775d5d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6396,PubChem,C[Si](C)(C)C,Train,1,2702,training
-"JP_CHRIP:
-Chlorotrimethylsilane
-
-NZ_CCID:
-Silane, chlorotrimethyl-","JP_CHRIP:
-chlorotrimethylsilane
-Chlorotrimethylsilicane
-Trimethyl silyl chloride
-
-NZ_CCID:
-Monochlorotrimethylsilicon, Trimethylsilyl chloride",75-77-4,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0058e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0036D01A-4B62-4627-B792-16E149A31F1B","JP_CHRIP:
-There is a report of ""Necrosis, accompanied by severe erythema, moderate edema, and desquamation was observed within 1-hour after application of 0.5 mL to the skin of rabbits for 4-hour. The effects persisted through 1-week observation period. Although the skin primary irritation index was 2.2/8.0 (HSDB (2007)), the substance was classified into Category 1 based on a report of ""highly corrosive"" in another rabbit test (IUCLID (2000)) and a report of ""corrosive to the skin"" (HSDB (2007)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Highly corrosive.
-REFERENCE SOURCE: Elf Atochem UK Ltd Newbury - Berkshire RG 13 4 LW (26) [IUCLID 2000]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Highly corrosive.
-REFERENCE SOURCE: DOW Corning Europe La Hulpe
-(27) [IUCLID 2000]
-REMARK: EC Classification = Risk of serious damage to the eyes.",,"JP_CHRIP, NZ_CCID",2,C[Si](C)(C)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.466D,J-GLOBAL,C[Si](C)(C)Cl,Train,1,2702,training
-"JP_CHRIP:
-Dichloro(dimethyl)silane
-
-NZ_CCID:
-Silane, dichlorodimethyl-","JP_CHRIP:
-Chlorodimethylsilane
-
-NZ_CCID:
-Dichlorodimethyl silane, Dimethyldichlorosilane",75-78-5,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0054e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FD91E8A4-D757-4E4A-BE6C-F879266F2EA1","JP_CHRIP:
-Based on a result of ""corrosive"" in a rabbit test (IUCLID (2002)) and ""contact with liquid causes severe burns of the skin"" (HSDB (2002)), the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-Based on sub risk 8 PG II [UNTDGMR]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Corrosive. Severe damage of the cornea and lids.
-REFERENCE SOURCE: [Peer Reviewed] [Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986. 224] [HSDB]",,"JP_CHRIP, NZ_CCID",2,C[Si](C)(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.467B,J-GLOBAL,C[Si](C)(Cl)Cl,Train,1,2702,training
-"JP_CHRIP:
-Trichloro(methyl)silane
-
-NZ_CCID:
-Silane, trichloromethyl-","JP_CHRIP:
-Trichloromethylsilane
-
-NZ_CCID:
-Methyltrichlorosilane, Trichloromethylsilane, trichloro(methyl)silane",75-79-6,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0057e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A46368C7-36B8-4DA8-8F19-FA7CB121916A","JP_CHRIP:
-Based on a result of ""corrosive"" in a rabbit test (IUCLID (2000)) and ""causes severe skin burns"" as a human health effects (HSDB (2007)), the substance was classified into Category 1. As relevant information, in EU classification, the substance is classified into Xi: R36/37/38 (EU-Annex I (access on Aug. 2009)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES:
-RESULT: Corrosive
-REFERENCE SOURCE: Rhone-Poulenc Chimie Courbevoie Cedex; Registry of Toxic Effects of Chemical Substances [iuclid 2000]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Cause severe burns of cornea and eyelids.
-REFERENCE SOURCE: [Lefaux, R. Practical Toxicology of Plastics. Cleveland: CRC Press Inc., 1968. 109]**PEER REVIEWED** [HSDB]",,"JP_CHRIP, NZ_CCID",2,C[Si](Cl)(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J54.325J,J-GLOBAL,C[Si](Cl)(Cl)Cl,Train,1,2702,training
-"JP_CHRIP:
-2-Methyl-2-butanol",,75-85-4,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0141e.html,"JP_CHRIP:
-From the information that semi-occlusive application to rabbit skin (covered with a cloth) caused redness and exfoliation as a result (PATTY (5th, 2001)), it was classified in Category 2.
-Besides, it is reported that open application did not cause irritation even when applied repeatedly and occlusive application with an impermeable material caused severe necrosis (PATTY (5th, 2001)).
-But the result of semi-occlusive application shown in an OECD test guideline was used as a basis for classification.
-Besides, ""Xi; R37/38"" classification in EU classification (EC-JRC (ESIS) (Access on Nov. 2011)) corresponds to Category 2.",,JP_CHRIP,1,CCC(C)(C)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.164E,J-GLOBAL,CCC(C)(C)O,Train,1,2702,training
-"NZ_CCID:
-2,2,2-Trifluoroethanol",,75-89-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/421BE5F9-EC7D-4DEC-8134-BABB88AD4B79,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 41 [Company Data]",,NZ_CCID,1,C(C(F)(F)F)O,https://pubchem.ncbi.nlm.nih.gov/compound/6409,PubChem,OCC(F)(F)F,Train,1,2702,training
-"AU_HCIS:
-Hydroperoxide, 1,1-dimethylethyl
-
-JP_CHRIP:
-tert-Butyl hydroperoxide
-
-NZ_CCID:
-Hydroperoxide, 1,1-dimethylethyl, 70% aqueous solution
-
-US_HSDB:
-tert-Butyl hydroperoxide","AU_HCIS:
-tert-butyl hydroperoxide
-1,1-dimethylethyl hydroperoxide
-2-hydroperoxy-2-methylpropane
-Perbutyl H
-TBHP
-
-JP_CHRIP:
-tert-Butyl-hydroperoxide
-1,1-Dimethylethylhydroxiperoxide
-2-Hydroperoxy-2-methylpropane
-Hydroperoxide, 1,1-dimethylethyl
-tert-Butyl hydroperoxide
-tert-Butylhydroperoxide
-
-NZ_CCID:
-tert-Butyl hydroperoxide",75-91-2,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5493
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2058e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DB51077E-DE08-40B3-A86A-0BB623CA787F
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/837","JP_CHRIP:
-Based on reports that in skin irritation tests with rabbits, corrosivity or severe irritation with necrosis was observed in all of the three tests (EU-RAR (2006)), it was classified in Category 1.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Corrosive
-REFERENCE SOURCE: RCO Chemical Europe, Inc. Maidenhead, Berkshire (28) Test Species/Strain: Albino Rabbit-New Zealand, White. (29) W. E. Field (1981). Tertiary Butyl Hydroperoxide (70%) - Primary
-Skin Irritation Study in Rabbits. Chemicals, Drugs, and Cosmetics Research, Inc. Study No. CDC-AR-003-81 (client ARCO Chemical Company), report dated June 29, 1981. Unpublished data [IUCLID 2000]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Highly irritating
-REFERENCE SOURCE: ARCO Chemical Europe, Inc. Maidenhead, Berkshire (32) W. E. Field (1981). Tertiary Butyl Hydroperoxide (70%) - Acute
-Eye Irritation Study in Albino Rabbits. Chemicals, Drugs, and Cosmetics Research, Inc. Study No. CDC-AR-002-81 (client ARCO Chemical Company), reported dated June 5, 1981. Unpublished data [IUCLID 2000]
-REMARK: EC Classificaton = Risk of serious damage to eyes",,"AU_HCIS, JP_CHRIP, NZ_CCID, US_HSDB",4,CC(C)(C)OO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.397C,J-GLOBAL,CC(C)(C)OO,Train,1,2702,training
-"JP_CHRIP:
-Trichloro(vinyl)silane
-
-NZ_CCID:
-Trichlorovinylsilane",,75-94-5,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0019e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/40A9A9DD-3785-4F8C-8299-664C8EB71466","JP_CHRIP:
-Based on reports of ""corrosive"" in a skin primary irritation test with rabbits (IUCLID (2000)), and ""corrosive"" in another test with rabbits (IUCLID (2000)), the substance was classified into Category 1. As relevant information, in EU classification, the substance is classified into C; R34.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 35 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,"JP_CHRIP, NZ_CCID",2,Cl[Si](Cl)(Cl)C=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.505K,J-GLOBAL,C=C[Si](Cl)(Cl)Cl,Train,1,2702,training
-"JP_CHRIP:
-2,2-Dimethylpropanoic acid
-
-NZ_CCID:
-Pivalic acid","JP_CHRIP:
-2,2-Dimethylpropanoic acid
-alpha,alpha-Dimethylpropionic acid
-Neopentanoic acid
-Propanoic acid, 2,2-dimethyl-
-Trimethylacetic acid",75-98-9,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0067e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F01D3667-6D48-4BD4-9EB2-A71DC2E889C7","JP_CHRIP:
-It was assessed as ""highly irritating"" resulting from 24, 48-hour average scores of 2.8 and 2.6 for erythema and edema respectively and maximum score of 4 shown in 2 out of 4 animals throughout the 7-day observation period in a Draize test by 24-hour occlusive application of 0.5 mL of this substance to rabbits. (IUCLID (2000))
-And it was assessed as ""moderately irritating"" in another Draize test by 24-hour occlusive application of 0.5 mg of this substance to rabbits. (IUCLID (2000))
-From the above, it was classified in Category 2.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 41 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CC(C)(C)C(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.166A,J-GLOBAL,CC(C)(C)C(=O)O,Train,1,2702,training
-"JP_CHRIP:
-2,2-Dichloropropionic acid; Dalapon
-
-NZ_CCID:
-Dalapon","JP_CHRIP:
-2,2-Dichloropropionic acid
-alpha,alpha-Dichloropropionic acid
-Dalapon
-Propanoic acid, 2,2-dichloro-",75-99-0,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2038e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C5573584-4FFE-43BD-BE5F-896C0FFAFCD7","JP_CHRIP:
-[Rationale for the Classification]
-It was classified in Category 2 from (1), (2). The classification result was changed due to new data obtained.
-
-[Evidence Data]
-(1) This substance was irritating to the eye, skin, and respiratory tract (GESTIS (Access on May 2020)).
-(2) This substance was moderately irritating to the eye and skin (HSDB (Access on May 2020)).
-
-[Reference Data, etc.]
-(3) It was classified in Skin Irrit. 2 (H315) in EU-CLP classification (EU CLP classification (Access on May 2020)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES:
-RESULT: Moderate irritation..upon prolonged contact.
-REFERENCE SOURCE: [Weed Science Society of America. Herbicide Handbook. 5th ed. Champaign, Illinois: Weed Science Society of America, 1983. 137]**PEER REVIEWED** [HSDB]
-
-Eye Irritation
-R-PHRASE: R 41 Risk of serious damage to eyes.
-[NCLASS]",,"JP_CHRIP, NZ_CCID",2,CC(Cl)(Cl)C(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.399J,J-GLOBAL,CC(Cl)(Cl)C(=O)O,Train,1,2702,training
-"JP_CHRIP:
-3,4-Dichloro-1-butene","JP_CHRIP:
-3,4-dichloro-1-butene",760-23-6,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0047e.html,"JP_CHRIP:
-In the 4-hour rabbit test (OECD TG404, GLP-compliant), application of 0.5 ml of the undiluted test substance for three animals caused slightly irritating with erythema (grade 1 or 2) until 72 hours after removal of patch in all animals. And the mean scores of erythema or edema at 24, 48 and 72 hours after removal of the patch were less than 2.3 (SIDS (2001)). Based on the document, the substance was classified as ""Not classified"" in the JIS classification (corresponding to Category 3 in the UN-GHS classification).",Provided,JP_CHRIP,1,ClCC(Cl)C=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.728K,J-GLOBAL,C=CC(Cl)CCl,Train,1,2702,training
-"NZ_CCID:
-Trichloroacetyl chloride",,76-02-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9FADD646-63DF-407C-B5F3-A800A3525013,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 35 [Company Data]
-Eye Irritation
-R PHRASE: R 35 [Company Data]",,NZ_CCID,1,C(=O)(C(Cl)(Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/6420,PubChem,O=C(Cl)C(Cl)(Cl)Cl,Train,1,2702,training
-"AU_HCIS:
-TCA (ISO)
-
-JP_CHRIP:
-Trichloroacetic acid
-
-KR_NCIS:
-Trichloroacetic acid
-
-NZ_CCID:
-Trichloroacetic acid","JP_CHRIP:
-Aceto-caustin
-TCA
-Trichloroethanoic acid
-
-NZ_CCID:
-Aceto-caustin, Acetic acid, trichloro-, TCA, Trichloracetic acid, Trichloroacetate, Trichloroethanoic acid",76-03-9,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4337
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2011e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/55F75828-C966-4DF7-AE25-550132752277","JP_CHRIP:
-There is a result of corrosive to the skin of rabbits (SIDS (access on April. 2009)). In another rabbit test, there are results of ""slight irritation"" after application of 0.21 mg and ""severe irritation"" after application of 3.5 mg (BUA 167 (1995)). Additionally, it has been reported that depending upon concentration and duration of contact, the substance can produce burns (ACGIH (2001)). Based on these information and a pH of < 1 (900 g/L, 20 degC) (IUCLID (2000)), the substance was classified into Category 1. As relevant information, the substance is classified into C; R35 in EU classification.
-
-NZ_CCID:
-Skin Irritation
-SPECIES:
-RESULT: It is a corrosive organic acid which rapidly penetrates and ""fixes"" tissues. Systemic effects are presumably secondary to GI damage and to acidosis, not due to toxicity (i.e. simple salts are not hazardous).
-REFERENCE: [Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. II-103]**PEER REVIEWED** [HSDB]
-Eye Irritation
-SPECIES:
-RESULT: It is a corrosive organic acid which rapidly penetrates and ""fixes"" tissues. Systemic effects are presumably secondary to GI damage and to acidosis, not due to toxicity (i.e. simple salts are not hazardous).
-REFERENCE: [Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. II-103]**PEER REVIEWED**[HSDB]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID",4,OC(=O)C(Cl)(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.400G,J-GLOBAL,O=C(O)C(Cl)(Cl)Cl,Train,1,2702,training
-"JP_CHRIP:
-Trifluoroacetic acid
-
-NZ_CCID:
-Trifluoroacetic acid","JP_CHRIP:
-Acetic acid, trifluoro-
-Perfluoroacetic acid",76-05-1,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0142e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C6566382-DE45-45E2-805C-FDC81EB750CD","JP_CHRIP:
-From the information that this substance has a pH of 1 (10 g/L) (GESTIS (Access on Nov. 2011)), it was classified in Category 1.
-Besides, it is classified in C; R35 in EU classification (EC-JRC (ESIS) (Access on Nov. 2011)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 35 [Company Data]
-Eye Irritation
-R PHRASE: R 35 [Company Data]",,"JP_CHRIP, NZ_CCID",2,OC(=O)C(F)(F)F,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.401E,J-GLOBAL,O=C(O)C(F)(F)F,Train,1,2702,training
-"EU_CLP:
-trichloronitromethane; chloropicrin",,76-06-2,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C([N+](=O)[O-])(Cl)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/6423,PubChem,O=[N+]([O-])C(Cl)(Cl)Cl,Test,1,2702,training
-"JP_CHRIP:
-2-Ethylhexanoyl chloride","JP_CHRIP:
-2-Ethylhexanoyl chloride",760-67-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0035e.html,"JP_CHRIP:
-It was classified in Category 1 from a result as ""corrosive"" in a test using rabbits (OECD TG404, GLP compliance) (IUCLID (2000)).
-Besides, another rabbit test reports that necrosis was observed 72 hours and 7 days after application (Directive 84/449/EEC B.4, GLP compliance) (IUCLID (2000)).",Provided,JP_CHRIP,1,CCCCC(CC)C(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J150.162C,J-GLOBAL,CCCCC(CC)C(=O)Cl,Train,1,2702,training
-"EU_REACH:
-2-propynyl-butylcarbamate",,76114-73-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12315/7/4/2/?documentUUID=1045670c-9e91-4b66-b0f6-a791a27ab2ab,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCNC(=O)OCC#C,https://pubchem.ncbi.nlm.nih.gov/compound/10877354,PubChem,C#CCOC(=O)NCCCC,Train,1,2702,training
-"JP_CHRIP:
-tetrachloro-1,2-difluoroethane; 1,1,2,2-Tetrachloro-1,2-difluoroethane (synonym: CFC-112)","JP_CHRIP:
-1,2-Difluoro-1,1,2,2-tetrachloroethane
-1,2-Difluoro-1,1,2,2-tetrafluoroethane
-CFC-112
-Ethane, 1,1,2,2-tetrachloro-1,2-difluoro-
-Fluorocarbon 112",76-12-0,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0828e.html,"JP_CHRIP:
-Since erythema (erythema) was accepted with the rabbit (EHC 113 (1990)), it was set as Category 2.",,JP_CHRIP,1,FC(Cl)(Cl)C(F)(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.473G,J-GLOBAL,FC(Cl)(Cl)C(F)(Cl)Cl,Train,1,2702,training
-"EU_REACH:
-decanoyl decaneperoxoate",,762-12-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5297/7/4/2/?documentUUID=692adb48-9c50-4adc-ba00-250cabbe0b6f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCC(=O)OOC(=O)CCCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/69802,PubChem,CCCCCCCCCC(=O)OOC(=O)CCCCCCCCC,Train,1,2702,training
-"NZ_CCID:
-2-Chloropropionyl chloride",,7623-09-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F6CA10ED-7755-47ED-9907-FA0539BCF9A9,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C(=O)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/111019,PubChem,CC(Cl)C(=O)Cl,Train,1,2702,training
-"NZ_CCID:
-Dimethyl acetylenedicarboxylate",,762-42-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1D464ACD-E0FD-47CF-9100-162F5EC966AB,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,COC(=O)C#CC(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/12980,PubChem,COC(=O)C#CC(=O)OC,Train,1,2702,training
-"NZ_CCID:
-Allyltrimethylsilane",,762-72-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/665D2BFB-3508-42AC-B2BB-09FCB0533E76,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C[Si](C)(C)CC=C,https://pubchem.ncbi.nlm.nih.gov/compound/69808,PubChem,C=CC[Si](C)(C)C,Train,1,2702,training
-"EU_REACH:
-(2R,3R,4R,5S)-6-(dimethylamino)hexane-1,2,3,4,5-pentol",,76326-99-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18179/7/4/2/?documentUUID=c3191a12-02d1-4a9a-8bdf-b433b2dcdc05,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C)C[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/11564307,PubChem,CN(C)C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO,Train,1,2702,training
-"NZ_CCID:
-2-Butyne-1-ol","NZ_CCID:
-2-butyn-1-ol",764-01-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A123F203-E66C-491D-A6F4-CF3EE48F0F46,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC#CCO,https://pubchem.ncbi.nlm.nih.gov/compound/12991,PubChem,CC#CCO,Train,1,2702,training
-"JP_CHRIP:
-2-Butene, 1,4-dichloro-
-
-NZ_CCID:
-2-Butylene dichloride","JP_CHRIP:
-1,4-Dichloro-2-butene
-
-NZ_CCID:
-2-Butene, 1,4-dichloro-",764-41-0,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-2029e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8338B2DC-1229-4D51-8042-BD9984B882A8","JP_CHRIP:
-The treatment of the forearms of human volunteers for 0.5 to 1 hour with the undiluted substance caused marked erythema, edema, and development of blisters (SIDS (2006)). Liquid and vapors of the substance caused extremely corrosive to human skin (SIDS (2006)). Based on the information, the substance was classified as Category 1.
-
-NZ_CCID:
-Skin Irritation
-REMARK: Original Corr82 Classification: Corr82RD. Tox63 Classification: Tox63RD Skin absorption.
-[NZ WES 2001]
-Eye Irritation
-R-PHRASE: R 34. [ECB]",,"JP_CHRIP, NZ_CCID",2,ClCC=CCCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.024D,J-GLOBAL,ClCC=CCCl,Train,1,2702,training
-"EU_REACH:
-N-(2-hydroxyethyl)prop-2-enamide",,7646-67-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33694/7/4/2/?documentUUID=2421b2c3-50e9-41e4-8cb7-4d92c5aee492,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CC(=O)NCCO,https://pubchem.ncbi.nlm.nih.gov/compound/193628,PubChem,C=CC(=O)NCCO,Train,1,2702,training
-"NZ_CCID:
-Nonanoyl chloride",,764-85-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0C514427-0911-4AD2-ADAB-0567AF3C7B63,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCCCCCCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/69819,PubChem,CCCCCCCCC(=O)Cl,Train,1,2702,training
-"EU_REACH:
-{2-[2-(ethenyloxy)ethoxy]ethoxy}ethene",,764-99-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11118/7/4/2/?documentUUID=32175c7c-fc1f-406c-97df-777b04a22f58,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=COCCOCCOC=C,https://pubchem.ncbi.nlm.nih.gov/compound/12998,PubChem,C=COCCOCCOC=C,Train,1,2702,training
-"EU_REACH:
-3,6,9,12-tetraoxatetradeca-1,13-diene",,765-12-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10352/7/4/2/?documentUUID=b60d6f4a-929a-4b14-9ac3-b0dc6316c185,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=COCCOCCOCCOC=C,https://pubchem.ncbi.nlm.nih.gov/compound/3033992,PubChem,C=COCCOCCOCCOC=C,Train,1,2702,training
-"KR_NCIS:
-1,1‘-(1,3-Phenylenedicarbonyl)bis(methylaziridine)",,7652-64-4,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CC1CN1C(=O)C2=CC(=CC=C2)C(=O)N3CC3C,https://pubchem.ncbi.nlm.nih.gov/compound/24301,PubChem,CC1CN1C(=O)c1cccc(C(=O)N2CC2C)c1,Train,1,2702,training
-"NZ_CCID:
-Cyclopropylamine",,765-30-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/70475B82-FDF8-48BE-B608-87FF41C4A025,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CC1N,https://pubchem.ncbi.nlm.nih.gov/compound/69828,PubChem,NC1CC1,Train,1,2702,training
-"EU_REACH:
-2-ethylhexyl 2-sulfanylacetate
-
-JP_CHRIP:
-2-Ethylhexyl thioglycolate","JP_CHRIP:
-2-ethylhexyl mercaptoacetate
-2-Ethylhexyl mercaptoacetate; 2-Ethylhexyl mercaptoacetate; 2-Ethylhexyl thioglycolate
-2-ethylhexyl thioglycolate",7659-86-1,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13385/7/4/2/?documentUUID=0c3d17b1-e1c3-47f4-a848-27c7dfe0185d
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0147e.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-In the rabbit test (OECD TG404, GLP-compliant), average scores of each 3 animals at 24, 48 and 72 hours after application were 1.3, 1.7, and 1.3 for erythema, 0.0, 0.0, and 0.3 for edema, respectively, and the symptoms were all reversible within 6 days and 3 days respectively. Thus, the substance was concluded as slightly irritating (IUCLID (2000)). Because the average score of erythema or edema was less than 1.5 in at least two of three animals, the substance was classified as ""Not classified"".",Provided,"EU_REACH, JP_CHRIP",2,CCCCC(CC)COC(=O)CS,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J150.356A,J-GLOBAL,CCCCC(CC)COC(=O)CS,Train,1,2702,training
-"NZ_CCID:
-Piperidine, 1-ethyl-","NZ_CCID:
-1-Ethylpiperidine",766-09-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A64BAB75-D32E-4AAC-92C9-AB79E3063A7F,"NZ_CCID:
-Skin Irritation
-SPECIES:
-RESULT: Severe burns.
-REEFERENCE SOURCE: [MSDS]
-Eye Irritation
-SPECIES:
-RESULT: Can cause severe burns leading to permanent damage.
-REFERENCE SOURCE: [NJHS]",,NZ_CCID,1,CCN1CCCCC1,https://pubchem.ncbi.nlm.nih.gov/compound/13007,PubChem,CCN1CCCCC1,Train,1,2702,training
-"AU_HCIS:
-Oxirane, [(1,1-dimethylethoxy)methyl]-",,7665-72-7,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5437,,,AU_HCIS,1,CC(C)(C)OCC1CO1,https://pubchem.ncbi.nlm.nih.gov/compound/24314,PubChem,CC(C)(C)OCC1CO1,Train,1,2702,training
-"NZ_CCID:
-1-(Bromomethyl)-3-chlorobenzene",,766-80-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/345D64EB-32AC-4074-BF1D-FD9424CAA2A3,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC(=CC(=C1)Cl)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/69838,PubChem,Clc1cccc(CBr)c1,Train,1,2702,training
-"NZ_CCID:
-4-Hydroxybenzonitrile","NZ_CCID:
-4-cyanophenol",767-00-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E61E481A-12E6-4CB9-8704-1F97ED72D670,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1C#N)O,https://pubchem.ncbi.nlm.nih.gov/compound/13019,PubChem,N#Cc1ccc(O)cc1,Train,1,2702,training
-"NZ_CCID:
-Chlorotriphenylmethane","NZ_CCID:
-triphenylmethyl chloride",76-83-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F212F0D2-1E82-4893-B4CF-974C6438EEBD,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/6456,PubChem,ClC(c1ccccc1)(c1ccccc1)c1ccccc1,Train,1,2702,training
-"EU_CLP:
-4-phenylbut-1-ene",,768-56-9,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C=CCCC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/13033,PubChem,C=CCCc1ccccc1,Test,1,2702,training
-"NZ_CCID:
-Chlorotriphenylsilane","NZ_CCID:
-triphenylsilyl chloride",76-86-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F47F505C-8984-4379-AA6C-596F759A9939,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)[Si](C2=CC=CC=C2)(C3=CC=CC=C3)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/6458,PubChem,Cl[Si](c1ccccc1)(c1ccccc1)c1ccccc1,Train,1,2702,training
-"EU_REACH:
-bis(ethenyldimethylsilyl)amine",,7691-02-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5675/7/4/2/?documentUUID=d0eb5a4d-f291-4152-9581-3f75b0ccada4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](C)(C=C)N[Si](C)(C)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/82126,PubChem,C=C[Si](C)(C)N[Si](C)(C)C=C,Train,1,2702,training
-"NZ_CCID:
-4-Nitrophenyl chloroformate",,7693-46-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/099E9397-8468-4947-93F2-7EC65102EF98,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1[N+](=O)[O-])OC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/82129,PubChem,O=C(Cl)Oc1ccc([N+](=O)[O-])cc1,Train,1,2702,training
-"EU_REACH:
-phenyl dichlorophosphate
-
-NZ_CCID:
-Phenyl dichlorophosphate",,770-12-7,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20440/7/4/2/?documentUUID=3eea564c-d01c-4e0a-86b8-5a2fa86332d3
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A45219D1-39BA-409F-8BC2-2399D99198F3","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",Provided,"EU_REACH, NZ_CCID",2,C1=CC=C(C=C1)OP(=O)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/13038,PubChem,O=P(Cl)(Cl)Oc1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-1-Phenoxy-2-propanol","JP_CHRIP:
-1-Phenoxy-2-propanol; 1-Phenoxy-2-propanol",770-35-4,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-0010e.html,"JP_CHRIP:
-It was classified as ""Not classified"" because no irritation was observed in a skin irritation test with rabbits according to OECD TG 404 (SIDS (2006))",Provided,JP_CHRIP,1,CC(O)COc1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J47.817B,J-GLOBAL,CC(O)COc1ccccc1,Train,1,2702,training
-"EU_CLP:
-dichloro-(3-(3-chloro-4-fluorophenyl)propyl)methylsilane",,770722-36-6,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C[Si](CCCC1=CC(=C(C=C1)F)Cl)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10902186,PubChem,C[Si](Cl)(Cl)CCCc1ccc(F)c(Cl)c1,Test,1,2702,training
-"EU_CLP:
-chloro(3-(3-chloro-4-fluorophenyl)propyl)dimethylsilane",,770722-46-8,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C[Si](C)(CCCC1=CC(=C(C=C1)F)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/57509075,PubChem,C[Si](C)(Cl)CCCc1ccc(F)c(Cl)c1,Test,1,2702,training
-"EU_CLP:
-1,2,3,4-tetrahydro-1-naphthyl hydroperoxide",,771-29-9,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1CC(C2=CC=CC=C2C1)OO,https://pubchem.ncbi.nlm.nih.gov/compound/69866,PubChem,OOC1CCCc2ccccc21,Test,1,2702,training
-"EU_CLP:
-1,6-bis(3,3-bis((1-methylpentylidenimino)propyl)ureido)hexane",,771478-66-1,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCCCC(=NCCCNC(=O)NCCCCCCNC(=O)NCCCN=C(C)CCCC)C,https://pubchem.ncbi.nlm.nih.gov/compound/165341011,PubChem,CCCCC(C)=NCCCNC(=O)NCCCCCCNC(=O)NCCCN=C(C)CCCC,Test,1,2702,training
-"NZ_CCID:
-2,4,6-Trimethylbenzenesulphonyl chloride","NZ_CCID:
-2-mesitylenesulfonyl chloride",773-64-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/764121D3-2A9C-41D3-B105-3E3341407B5A,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC1=CC(=C(C(=C1)C)S(=O)(=O)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/13046,PubChem,Cc1cc(C)c(S(=O)(=O)Cl)c(C)c1,Train,1,2702,training
-"EU_CLP:
-methyl acrylamidoglycolate (containing ≥ 0,1 % acrylamide)",,77402-05-2,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,COC(=O)C(NC(=O)C=C)O,https://pubchem.ncbi.nlm.nih.gov/compound/157058,PubChem,C=CC(=O)NC(O)C(=O)OC,Test,1,2702,training
-"NZ_CCID:
-2-Bromo-4-nitrotoluene",,7745-93-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/034186FF-9449-4B71-8A52-32ACE8E33682,,,NZ_CCID,1,CC1=C(C=C(C=C1)[N+](=O)[O-])Br,https://pubchem.ncbi.nlm.nih.gov/compound/82189,PubChem,Cc1ccc([N+](=O)[O-])cc1Br,Train,1,2702,training
-"EU_REACH:
-(2-ethoxy-1-methyl-2-oxoethyl)-5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate",,77501-63-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6560/7/4/2/?documentUUID=f46e7653-b19a-43ec-9bd8-8269c371f3a5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C(C)OC(=O)C1=C(C=CC(=C1)OC2=C(C=C(C=C2)C(F)(F)F)Cl)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/62276,PubChem,CCOC(=O)C(C)OC(=O)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-],Train,1,2702,training
-"NZ_CCID:
-Diphenylsilane",,775-12-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7A2E92BB-B0D0-49BD-806A-CA66C7959BE6,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)[Si]C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/6327659,PubChem,c1ccc([Si]c2ccccc2)cc1,Train,1,2702,training
-"NZ_CCID:
-Phenol, 2,4-dimethyl-6-(1-methylcyclohexyl)-",,77-61-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2F3794A8-545F-4348-8740-A5049AD87D27,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,CC1=CC(=C(C(=C1)C2(CCCCC2)C)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/6485,PubChem,Cc1cc(C)c(O)c(C2(C)CCCCC2)c1,Train,1,2702,training
-"EU_REACH:
-2-{[2-hydroxy-5-methyl-3-(1-methylcyclohexyl)phenyl]methyl}-4-methyl-6-(1-methylcyclohexyl)phenol",,77-62-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22349/7/4/2/?documentUUID=178e25f8-8a7c-473e-b701-7683ea2399f5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C(=C1)C2(CCCCC2)C)O)CC3=C(C(=CC(=C3)C)C4(CCCCC4)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/6486,PubChem,Cc1cc(Cc2cc(C)cc(C3(C)CCCCC3)c2O)c(O)c(C2(C)CCCCC2)c1,Train,1,2702,training
-"NZ_CCID:
-Bromodiphenylmethane","NZ_CCID:
-diphenylmethyl bromide",776-74-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/58B7B1D2-6879-44BB-820A-E3BD64346A5F,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)C(C2=CC=CC=C2)Br,https://pubchem.ncbi.nlm.nih.gov/compound/236603,PubChem,BrC(c1ccccc1)c1ccccc1,Train,1,2702,training
-"EU_REACH:
-3-butyl-1-[4-({4-[(butylcarbamoyl)amino]phenyl}methyl)phenyl]urea",,77703-56-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13359/7/4/2/?documentUUID=f924baf8-521f-4986-a8ba-b7b61f3f1b7e,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCNC(=O)NC1=CC=C(C=C1)CC2=CC=C(C=C2)NC(=O)NCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/3576105,PubChem,CCCCNC(=O)Nc1ccc(Cc2ccc(NC(=O)NCCCC)cc2)cc1,Train,1,2702,training
-"EU_REACH:
-tris(2-methylnonacosyl) phosphite",,77745-66-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14205/7/4/2/?documentUUID=b6cc35a4-48f7-4316-be66-9eee5733f8a6,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CCCCCCCCCCOP(OCCCCCCCCCCC(C)C)OCCCCCCCCCCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/22630279,PubChem,CC(C)CCCCCCCCCCOP(OCCCCCCCCCCC(C)C)OCCCCCCCCCCC(C)C,Train,1,2702,training
-"NZ_CCID:
-Phosphorodichloridic acid, 4-nitrophenyl ester",,777-52-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EC33D186-2158-4A4A-9BB4-3B32CA997777,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC(=CC=C1[N+](=O)[O-])OP(=O)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/69898,PubChem,O=[N+]([O-])c1ccc(OP(=O)(Cl)Cl)cc1,Train,1,2702,training
-"AU_HCIS:
-dimethyl sulphate
-
-JP_CHRIP:
-Dimethyl sulfate
-
-KR_NCIS:
-Dimethyl sulfate
-
-NZ_CCID:
-Dimethyl sulphate","AU_HCIS:
-dimethyl sulfate
-
-JP_CHRIP:
-Dimethyl sulfate
-Dimethyl monosulfate
-dimethyl sulphate
-DMS
-Sulfuric acid dimethyl ester
-Sulfuric acid, dimethyl ester
-
-KR_NCIS:
-Sulfuric acid dimethyl ester
-
-NZ_CCID:
-Dimethyl monosulfate, Methyl sulfate, Sulfuric acid, dimethyl ester",77-78-1,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1420
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0619e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0B8B5C25-87C9-478A-AEDB-5896241CF2A2","JP_CHRIP:
-Based on descriptions that it has strong irritative and corrosive effect on human skin (CERI Hazard Data (1999)) and that necrosis was seen in rabbit skin application test (CERI Hazard Data (1999), EU-RAR (2002)), it was classified as Category 1A-1C.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID",4,COS(=O)(=O)OC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.823A,J-GLOBAL,COS(=O)(=O)OC,Train,1,2702,training
-"NZ_CCID:
-Hexahydro-1,3,5-triethyl-s-triazine",,7779-27-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2A03FCDE-A27E-4EAC-9C76-BFFF220AB917,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 35 [Company Data]
-Eye Irritation
-R PHRASE: R 41[Company Data]",,NZ_CCID,1,CCN1CN(CN(C1)CC)CC,https://pubchem.ncbi.nlm.nih.gov/compound/24512,PubChem,CCN1CN(CC)CN(CC)C1,Train,1,2702,training
-"EU_REACH:
-2,2'-[Ethylenebis(oxyphenyl-2,1-eneazo)]bis[N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxobutyramide",,77804-81-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14248/7/4/2/?documentUUID=76110feb-15db-4282-93c7-3797a77f89a0,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC2=C(C=C1)NC(=O)N2)N=NC3=CC=CC=C3OCCOC4=CC=CC=C4N=NC(C(=O)C)C(=O)NC5=CC6=C(C=C5)NC(=O)N6,https://pubchem.ncbi.nlm.nih.gov/compound/166497,PubChem,CC(=O)C(N=Nc1ccccc1OCCOc1ccccc1N=NC(C(C)=O)C(=O)Nc1ccc2[nH]c(=O)[nH]c2c1)C(=O)Nc1ccc2[nH]c(=O)[nH]c2c1,Train,1,2702,training
-"AU_HCIS:
-1-Penten-3-one, 1-(2,6,6-trimethyl-3-cyclohexen-1-yl)-",,7784-98-7,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5907,,,AU_HCIS,1,CCC(=O)/C=C/C1C(C=CCC1(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/5463913,PubChem,CCC(=O)/C=C/C1C(C)C=CCC1(C)C,Train,1,2702,training
-"EU_REACH:
-dichloro(3-chloropropyl)methylsilane",,7787-93-1,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11206/7/4/2/?documentUUID=178ecaf1-0774-4a73-a85f-6b56f501b26a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](CCCCl)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/82235,PubChem,C[Si](Cl)(Cl)CCCCl,Train,1,2702,training
-"EU_REACH:
-2-chloro-1-fluoro-4-(trifluoromethyl)benzene",,78068-85-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27506/7/4/2/?documentUUID=209cd6c1-58e0-43fa-aa20-43da89c1374b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C=C1C(F)(F)F)Cl)F,https://pubchem.ncbi.nlm.nih.gov/compound/157153,PubChem,Fc1ccc(C(F)(F)F)cc1Cl,Train,1,2702,training
-"NZ_CCID:
-Triethyl orthoacetate",,78-39-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4293C92C-F138-4D76-96B6-4F1DE3623808,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CCOC(C)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/66221,PubChem,CCOC(C)(OCC)OCC,Train,1,2702,training
-"JP_CHRIP:
-Triethyl phosphate","JP_CHRIP:
-Ethyl phosphate
-TEP
-Triethoxyphosphine oxide
-Triethyl phosphate",78-40-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0109e.html,"JP_CHRIP:
-Moderate irritation was noted in 1 of 3 tested animals in the animal experiment (OECD TG 404, GLP-compliant), but SIDS concluded that the substance was not a skin irritant in accordance with guideline (SIDS (Access on Nov. 2010)). The substance caused slight irritation to guinea pig, but caused non irritation to rabbit (BUA 37 (1989)). Based on these documents, the substance was classified as ""Not classified"".",Provided,JP_CHRIP,1,CCOP(=O)(OCC)OCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.406F,J-GLOBAL,CCOP(=O)(OCC)OCC,Train,1,2702,training
-"AU_HCIS:
-2,4,7-Decatrienoic acid, ethyl ester",,78417-28-4,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1156,,,AU_HCIS,1,CCC=CCC=CC=CC(=O)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/3018771,PubChem,CCC=CCC=CC=CC(=O)OCC,Train,1,2702,training
-"JP_CHRIP:
-Tris(2-ethylhexyl) phosphate
-
-NZ_CCID:
-Tris (2-ethylhexyl) phosphate","JP_CHRIP:
-2-Ethylhexanol, phosphate triester; Tri(2-ethylhexyl) phosphate
-Phosphoric acid tris(2-ethylhexyl) ester
-Trioctyl phosphate
-Tris(2-ethylhexyl) phosphate",78-42-2,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-meti-0020e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D999E14E-7893-4631-AA00-0A34BE81AB47","JP_CHRIP:
-It is described that in a skin irritation test (OECD TG 404) using rabbits, well-defined erythema, slight to moderate oedema, crust formation and desquamation were observed; PII (primary irritation index) was 4.2/8.0; and therefore, this substance is a moderate irritant to rabbit skin (Hazard Assessment Report (CERI, NITE, 2005), EHC 218 (2000)).
-From the above, this substance was classified in Category 2.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",Provided,"JP_CHRIP, NZ_CCID",2,CCCCC(CC)COP(=O)(OCC(CC)CCCC)OCC(CC)CCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.953D,J-GLOBAL,CCCCC(CC)COP(=O)(OCC(CC)CCCC)OCC(CC)CCCC,Train,1,2702,training
-"EU_REACH:
-1-(dioctylphosphoryl)octane",,78-50-2,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16452/7/4/2/?documentUUID=d8a0c9f2-40ed-4af2-8e7b-ce0e4ee7fe11,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCP(=O)(CCCCCCCC)CCCCCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/65577,PubChem,CCCCCCCCP(=O)(CCCCCCCC)CCCCCCCC,Train,1,2702,training
-"EU_REACH:
-6-(4-methylbenzenesulfonamido)hexanoic acid",,78521-39-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5536/7/4/2/?documentUUID=92b56796-fdb7-4e50-be01-6ce73a576bc0,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)S(=O)(=O)NCCCCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/95822,PubChem,Cc1ccc(S(=O)(=O)NCCCCCC(=O)O)cc1,Train,1,2702,training
-"NZ_CCID:
-Peroxide, (1,1,4,4-tetramethyl-1,4-butanediyl)bis[(1,1-dimethylethyl) 100%","NZ_CCID:
-(1,1,4,4-Tetramethyltetramethylene)bis(tert-butyl peroxide), 2,5-Bis(tert-butyldioxy)-2,5-dimethylhexane, 2,5-Bis(tert-butylperoxy)-2,5-dimethylhexane, 2,5-Dimethyl-2,5-bis(tert-butyldioxy)hexane, 2,5-Dimethyl-2,5-bis(tert-butylperoxy)hexane, 2,5-Dimethyl-2,5-di(tert-butylperoxy)hexane, Varox",78-63-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/54FC7CFA-0DA6-4894-AEFB-6FC73269B059,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [MSDS ALDRICH]
-Eye Irritation
-R PHRASE: R 36 [MSDS ALDRICH]",,NZ_CCID,1,CC(C)(C)OOC(C)(C)CCC(C)(C)OOC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6545,PubChem,CC(C)(C)OOC(C)(C)CCC(C)(C)OOC(C)(C)C,Train,1,2702,training
-"JP_CHRIP:
-3,7-Dimethyloctan-3-ol; Tetrahydrolinalool",,78-69-3,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2113e.html,"JP_CHRIP:
-[Rationale for the Classification]
-It was classified in Category 2 because Category 1 or 2 was estimated from (1), and the possibility of corrosion (Category 1) was considered to be low from (2). Besides, although the name of the skin model was not described in data of (1), it was judged that EpiDerm was used from test conditions, etc., and it was confirmed that it met the acceptance criteria for the current OECD TG 439, judging from test results.
-
-[Evidence Data]
-(1) In an in-vitro skin irritation test using reconstructed human epidermis model according to Draft OECD guideline, it was judged as irritating (REACH registration dossier (Access on November 2020)).
-(2) In a skin irritation test with rabbits (BASF test), after 1-minute, 5-minute, or 15-minute application to the dorsal skin, slight erythema was observed and disappeared after 6 days, and after 20-hour application to the auricle, well-defined to moderate erythema and edema were found and disappeared after 8 days (REACH registration dossier (Access on November 2020)).",,JP_CHRIP,1,CCC(C)(O)CCCC(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J354I,J-GLOBAL,CCC(C)(O)CCCC(C)C,Train,1,2702,training
-"EU_REACH:
-2-{4'-[difluoro(3,4,5-trifluorophenoxy)methyl]-3',5'-difluoro-[1,1'-biphenyl]-4-yl}-5-ethyloxane",,787582-75-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30133/7/4/2/?documentUUID=c0c81aef-3001-4edb-a95e-6502de724a6b,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1CCC(OC1)C2=CC=C(C=C2)C3=CC(=C(C(=C3)F)C(OC4=CC(=C(C(=C4)F)F)F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/58995748,PubChem,CCC1CCC(c2ccc(-c3cc(F)c(C(F)(F)Oc4cc(F)c(F)c(F)c4)c(F)c3)cc2)OC1,Train,1,2702,training
-"JP_CHRIP:
-2-Bromobutane","JP_CHRIP:
-2-Bromobutane",78-76-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2068e.html,"JP_CHRIP:
-Based on a report that erythema and edema were seen after the application of this substance in a rabbit skin irritation test (OECD TG 404-compliant) and the skin primary irritation index was 2.44 (erythema 1.78, edema 0.66) (ECETOC TR 66 (1995)), it was classified as ""Not classified"" (Category 3 in UN GHS classification).",Provided,JP_CHRIP,1,CCC(C)Br,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.481H,J-GLOBAL,CCC(C)Br,Train,1,2702,training
-"NZ_CCID:
-1-Bromo-2-methylpropane",,78-77-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/246D1FB5-A7CD-4A96-945D-B34949893569,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(C)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/6555,PubChem,CC(C)CBr,Train,1,2702,training
-"JP_CHRIP:
-Isobutylamine
-
-KR_NCIS:
-Isobutylamine","JP_CHRIP:
-1-Amino-2-methylpropane
-2-Methyl-1-propanamine
-2-Methylpropylamine
-
-KR_NCIS:
-1-Amino-2-methylpropane; 1-Propanamine, 2-methyl-; 2-Methyl-1-aminopropane; 2-Methyl-1-propanamine; 2-Methylpropan-1-amine; 2-Methylpropanamine; 2-Methylpropylamine; 3-Methyl-2-propylamine",78-81-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0008e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP:
-It was classified in Category 1 because it was judged that exposure causes irreversible damage to skin from a description as ""skin contact can result in erythema and blistering"" (PATTY (5th, 2001)), and a description as ""a powerful irritant to skin, eyes and mucous membrane"" accompanied by pain, redness, and burns to skin (HSDB (2008)).
-Besides, there is information that the substance is corrosive to the eyes, skin and respiratory tract as effects of short-time exposures (ICSC (J) (2005)).",,"JP_CHRIP, KR_NCIS",2,CC(C)CN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J46.573I,J-GLOBAL,CC(C)CN,Train,1,2702,training
-"EU_CLP:
-2-methylpropan-1-ol; iso-butanol",,78-83-1,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C)CO,https://pubchem.ncbi.nlm.nih.gov/compound/6560,PubChem,CC(C)CO,Test,1,2702,training
-"JP_CHRIP:
-Isobutyraldehyde","JP_CHRIP:
-2-Methyl-1-propanal
-2-Methylpropanal
-Isobutanal
-isobutylaldehyde",78-84-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-meti-2006e.html,"JP_CHRIP:
-[Rationale for the Classification]
-Based on (1) and (2), it was classified as ""Not classified."" Besides, because (3)-(5) are data in 1952, and the test details are unknown, and (6) is information from ICSC, these were not adopted for classification.
-
-[Evidence Data]
-(1) There is a report that in a skin irritation test with rabbits (OECD TG404, GLP, n=3), after 4-hour semi-occlusive application of this substance itself (purity 99% or more), erythema (score: 0.7-1.7) and edema (score: 0-0.3) were observed with recovery within 7 days (REACH registration dossier (Accessed Oct. 2018)).
-(2) There is a report that in a skin irritation test with rabbits (OECD TG404, GLP, n=4), in which this substance itself (purity 98%) was applied by using a patch for 4 hours, PII was is 0.13 in 72 hours (ECETOC TR66 (1995)).
-
-[Reference Data, etc.]
-(3) There is a report that in a skin irritation test with rabbits (n=6), after open application of this substance, significant erythema was observed in one animal (SIDS (2004)).
-(4) There is a description that this substance causes moderate to severe skin irritation and burns in rabbits (SIDS (2004)).
-(5) There is a description that this substance may be corrosive at extremely high concentrations (SIDS (2004)).
-(6) There is a description that this substance is corrosive to the skin, and that it causes pain, redness, blisters, and burns upon contact with the skin (Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)).",Provided,JP_CHRIP,1,CC(C)C=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.483D,J-GLOBAL,CC(C)C=O,Train,1,2702,training
-"JP_CHRIP:
-2-Methyl-2-propenal
-
-KR_NCIS:
-2-Methyl-2-propenal","JP_CHRIP:
-2-Methyl-2-propenal
-Isobutenal
-Methacrolein",78-85-3,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0065e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP:
-In rabbit test (OECD TG404), 4-hour application of 0.5 mL produced moderate erythema and oedema and skin primary irritation index was 4.11. Blanching was observed from day 3 and necrosis was observed from day 9 and persisted to the end of the observation period (ECETOC TR 66 (1995)). The substance was classified into Category 1 based on a result of irreversible symptoms in the rabbit test (ECETOC TR 66 (1995)) and a report of ""strong irritant"" for humans (HSDB (2002)).",Provided,"JP_CHRIP, KR_NCIS",2,CC(=C)C=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.484B,J-GLOBAL,C=C(C)C=O,Train,1,2702,training
-"EU_REACH:
-2-chlorobutane",,78-86-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5783/7/4/2/?documentUUID=71225670-2420-4844-9b2b-0c5e6a774cc6,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/6563,PubChem,CCC(C)Cl,Test,1,2702,training
-"JP_CHRIP:
-1,2-Dichloropropane","JP_CHRIP:
-1,2-Dichlorpropane
-dichloropropane
-propane, 1,2-dichloro-
-Propylene dichloride",78-87-5,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-2040e.html,"JP_CHRIP:
-The substance was classified into Category 2 since it was considered to be irritating based on the results of the skin irritation test using rabbits (Initial Risk Assessment Report (NITE, CERI, NEDO) No. 39 (2005)) and the report on the effect of the substance on humans (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) vol. 2 (2003)).",,JP_CHRIP,1,CC(Cl)CCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.486I,J-GLOBAL,CC(Cl)CCl,Train,1,2702,training
-"JP_CHRIP:
-2,3-Dichloropropene",,78-88-6,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0143e.html,"JP_CHRIP:
-Because in addition to the information that exposure to the skin causes severe skin irritation with a marked inflammatory response of epidermis and underlying tissues (HSDB (2003)), Xi; R37/38 in EU Classification (EC-JRC (ESIS) (Access on Nov. 2011)) was taken into consideration, it was classified in Category 2.
-Besides, List 2 data reported that 24-hour open application of 10 mg to rabbit skin caused severe irritation (RTECS (2006)).",,JP_CHRIP,1,ClCC(=C)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.223D,J-GLOBAL,C=C(Cl)CCl,Train,1,2702,training
-"JP_CHRIP:
-2-Chloro-1-propanol","JP_CHRIP:
-1-Propanol, 2-chloro-",78-89-7,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0005e.html,"JP_CHRIP:
-From the information that this substance is irritating to skin (HSDB (Access on June 2015)), it was classified in Category 2.",,JP_CHRIP,1,CC(Cl)CO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.224B,J-GLOBAL,CC(Cl)CO,Train,1,2702,training
-"JP_CHRIP:
-1,2-Propanediamine
-
-NZ_CCID:
-1,2-Diaminopropane","JP_CHRIP:
-1,2-Diaminopropane
-1,2-Propanediamine
-
-NZ_CCID:
-1,2-propylenediamine",78-90-0,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0128e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6501D508-797D-4E37-8053-90046273E16F","JP_CHRIP:
-There are results of ""corrosive"" in a rabbit test by occluded dermal application of 500 microL for 24-hour (IUCLID (2000)) and ""corrosive"" in another rabbit test by dermal application of undiluted substance for 15 min (IUCLID (2000)). The substance is classified into C; R35 in EU classification (EU-Annex I (access on Sep. 2009)). Based on these data, the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-UN #2258 UN CLASS: 8 PG II
-Eye Irritation
-R PHRASE: R 35 [Company Data]
-UN #2258 UN CLASS: 8 PG II",,"JP_CHRIP, NZ_CCID",2,CC(N)CN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.225K,J-GLOBAL,CC(N)CN,Train,1,2702,training
-"JP_CHRIP:
-2-Butanol","JP_CHRIP:
-1-Methyl propanol
-2-Butanol
-Butylene hydrate
-Methyl ethyl carbinol
-sec-Butyl alcohol",78-92-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2080e.html,"JP_CHRIP:
-There is a report that in a skin irritation test (OECD TG 404) with rabbits, the primary irritation score was 0, and it was not irritating (SIDS (2012), ECETOC JACC (2003)), and there are descriptions that it was not irritating to the skin (EHC 65 (1987), ACGIH (2002), DFGOT vol. 19 (2003)), and that it was very slightly irritating (PATTY (6th, 2012)). From the above results, it was classified as ""Not classified.""",Provided,JP_CHRIP,1,CCC(C)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.832K,J-GLOBAL,CCC(C)O,Train,1,2702,training
-"NZ_CCID:
-Triphenylsilane",,789-25-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BEEA242B-AB29-4BCA-9A29-56A3C2EAF31D,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)[Si](C2=CC=CC=C2)C3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/6327682,PubChem,c1ccc([Si](c2ccccc2)c2ccccc2)cc1,Train,1,2702,training
-"JP_CHRIP:
-Methyl ethyl ketone","JP_CHRIP:
-2-Butanone
-2-Butanone; Methyl ethyl ketone
-butanone
-MEK
-Methyl acetone
-Methyl ethyl ketone",78-93-3,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2100e.html,"JP_CHRIP:
-As a result of application of this substance to the skin of rabbits, there are reports of slight to moderate irritation (SIDS (2011), EHC 143 (1993), DFGOT vol. 12 (1999)) and of slight irritation (EHC 143 (1993), DFGOT vol. 12 (1999), PATTY (6th, 2012), ATSDR (1992)). In addition, in humans, there is a report that no irritation by exposure was seen (PATTY (6th, 2012)). From the above, based on the ""moderate irritation"" in rabbits, it was classified in Category 2.",,JP_CHRIP,1,CCC(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.960G,J-GLOBAL,CCC(C)=O,Train,1,2702,training
-"JP_CHRIP:
-Methyl vinyl ketone
-
-KR_NCIS:
-Methyl vinyl ketone
-
-NZ_CCID:
-Methyl vinyl ketone","JP_CHRIP:
-3-Buten-2-one
-3-Butene-2-one
-Methylene acetone
-
-KR_NCIS:
-1-Buten-3-one; 2-Butenone; 3-Buten-2-one; 3-Oxo-1-butene; 3-Oxobutene; Acetyl ethylene; Butenone; Methyl vinyl ketone; Methylene acetone
-
-NZ_CCID:
-1-Buten-3-one, 2-Butenone, 3-Buten-2-one, Butenone, Methylvinyl ketone, Methylvinylketone, Vinyl methyl ketone",78-94-4,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2004e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/40D0F8D4-93EA-4DF3-B988-BCCE7CE6866F","JP_CHRIP:
-[Rationale for the Classification]
-It was classified in Category 1 from (1) - (4).
-
-[Evidence Data]
-(1) This substance is a severe skin, eye, and respiratory tract irritant in humans and one of the more potent irritants of mucous membranes, particularly of the eye and respiratory tract (ACGIH (7th, 2001)).
-(2) This substance has a strong irritative effect on mucous membranes, and skin contact leads to severe necrosis (MAK (DFG) vol.9 (1998)).
-(3) This substance has strong irritative and corrosive effects on the skin and mucosa and causes severe eye and lung damage (GESTIS (Access on April 2020), HSDB (Access on April 2020)).
-(4) In a test in which this substance (0.2 mL) was applied to the rabbit skin (application time: unknown), hyperemia and edema occurred after 1 hour, edema disappeared on day 2, but deep purulent ulcers developed, and 28-30 days were required for recovery (MAK (DFG) vol.9 (1998)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,CC(=O)C=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J7H,J-GLOBAL,C=CC(C)=O,Train,1,2702,training
-"JP_CHRIP:
-2-Propanone, 1-chloro-
-
-NZ_CCID:
-Chloroacetone","JP_CHRIP:
-1-Chloro-2-propanone
-Acetonyl chloride
-Monochloroacetone
-
-NZ_CCID:
-1-Chloro-2-propanone, 1-Chloroacetone, 2-Propanone, 1-chloro-, 3-Chloro-2-propanone, Acetonyl chloride, Chloro-2-propanone, Chloromethyl methyl ketone, Chloropropanone, Monochloracetone, Monochloroacetone",78-95-5,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0699e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/78B28B2C-9C04-42F6-9710-F0EBB272887F","JP_CHRIP:
-Based on statements that moderate to severe erythemas and edemas were observed on the rabbit (BUA 226 (2000)) and that this product indicates skin corrosivenesses (ICSC (J) (1996)), it was classified as Category 1A-1C.
-
-NZ_CCID:
-Skin Irritation
-UN #1695 UN CLASS: 8 PG I
-Eye Irritation
-UN #1695 UN CLASS: 8 PG I",,"JP_CHRIP, NZ_CCID",2,CC(=O)CCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.487G,J-GLOBAL,CC(=O)CCl,Train,1,2702,training
-"AU_HCIS:
-2-Propanol, 1-amino-
-
-JP_CHRIP:
-1-aminopropan-2-ol; isopropanolamine
-
-NZ_CCID:
-Aminopropanol","AU_HCIS:
-1-aminopropan-2-ol
-isopropanolamine
-
-JP_CHRIP:
-1-aminopropan-2-ol
-2-Propanol, 1-amino-
-Isopropanolamine
-Threamine
-
-NZ_CCID:
-1-Amino-2-hydroxypropane, 1-Amino-2-propanol, 1-Aminopropan-2-ol, 1-Methyl-2-aminoethanol, 2-Amino-1-methylethanol, 2-Hydroxy-1-propylamine, 2-Hydroxypropanamine, 2-Hydroxypropylamine, 2-Propanol, 1-amino, Isopropanolamine, Monoisopropanolamine, Threamine, alpha-Aminoisopropyl alcohol",78-96-6,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3674
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0072e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EB896F26-395E-4244-BFED-E1176F9F5452","JP_CHRIP:
-Exposure time of 15 minutes and longer to undiluted application to rabbit skin led to the development of necrosis (DFGOT (1998)), and in a DOT corrosivity test, the substance was classified as corrosive to the skin (DFGOT (1998)). Thus, it was classified into Category 1. As relevant information, the pH of its high-concentration solution (10 g/L) is 11.3 (20degC) (IUCLID (2000)), and the substance is rated R24 in EU classification.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CC(O)CN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.961E,J-GLOBAL,CC(O)CN,Train,1,2702,training
-"US_HSDB:
-1,1-Dichloropropane",,78-99-9,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/5131,,,US_HSDB,1,CCC(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/6573,PubChem,CCC(Cl)Cl,Train,1,2702,training
-"JP_CHRIP:
-1,1,2-Trichloroethane","JP_CHRIP:
-Beta-trichloroethane
-ethane, 1,1,2-trichloro-
-Vinyl trichloride",79-00-5,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0124e.html,"JP_CHRIP:
-In studies using animals such as rabbits and others, irritation was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)). This substance was classified in Category 2 since skin irritation is also observed in humans (Environmental Risk Assessment for Chemical Substances Vol.2 (Ministry of the Environment, 2003)).",,JP_CHRIP,1,ClCC(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.962C,J-GLOBAL,ClCC(Cl)Cl,Train,1,2702,training
-"EU_REACH:
-4-(2-{4-[2-(3-cyanophenyl)ethenyl]phenyl}ethenyl)benzonitrile",,79026-02-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18823/7/4/2/?documentUUID=c6c46ec9-abee-4f2f-ad77-498d73cd9c9c,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC(=C1)C#N)/C=C/C2=CC=C(C=C2)/C=C/C3=CC=C(C=C3)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/19982709,PubChem,N#Cc1ccc(/C=C/c2ccc(/C=C/c3cccc(C#N)c3)cc2)cc1,Train,1,2702,training
-"NZ_CCID:
-Propionyl chloride
-
-US_HSDB:
-Propionyl chloride",,79-03-8,Cat 1,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F1182FB1-AE66-44B5-A2C3-A4A429138564
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8374","NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"NZ_CCID, US_HSDB",2,CCC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/62324,PubChem,CCC(=O)Cl,Train,1,2702,training
-"JP_CHRIP:
-Chloroacetyl chloride
-
-KR_NCIS:
-Chloroacetyl chloride
-
-NZ_CCID:
-Chloroacetyl chloride
-
-US_HSDB:
-Chloroacetyl chloride","JP_CHRIP:
-2-chloroacetyl chloride
-Chloroacetic acid chloride
-Chloroacetyl chloride
-Monochloroacetyl chloride
-
-KR_NCIS:
-2-Chloroacetyl chloride; Acetyl chloride, 2-chloro-; Acetyl chloride, chloro-; Chloroacetic Acid chloride; Chloroacetic chloride; Monochloroacetyl chloride
-
-NZ_CCID:
-Acetyl chloride, chloro-, Chloracetyl chloride, Chloroacetic acid chloride, Chloroacetic chloride, Monochloroacetyl chloride",79-04-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2037e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/304FEE4E-B4E4-48B6-A12A-480E0768125F
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/973","JP_CHRIP:
-Based on a report that it was corrosive when the undiluted liquid of this substance was applied to rabbits for 24 hours (HSDB (Access on June 2014)), and on a description that this substance was corrosive to the skin (ACGIH (7th, 2001), Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)), it was judged as Category 1. Besides, this substance was classified as ""C; R35"" in the EU DSD classification, and as ""H314 Skin Corr. 1A"" in the EU CLP classification. The category was changed by adding information.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 35 [Company Data]
-UN #1752 UN CLASS: 8 PG I
-Eye Irritation
-R PHRASE: R 35 [Company Data]
-UN #1752 UN CLASS: 8 PG I",,"JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",4,ClCC(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.490G,J-GLOBAL,O=C(Cl)CCl,Train,1,2702,training
-"JP_CHRIP:
-Bromoacetic acid
-
-NZ_CCID:
-Bromoacetic acid
-
-US_HSDB:
-Bromoacetic acid","JP_CHRIP:
-Bromoacetic acid
-
-NZ_CCID:
-Acetic acid, bromo-",79-08-3,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0027e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/21A01F8E-6D73-49DC-9FF1-77A9F4B830AF
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/7627","JP_CHRIP:
-Based on a report of ""Skin contact causes severe burns"" (HSDB (2009)) and classification as R35 in EU classification (EU-Annex I (2009)), the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-REMARK: UN1938 class 8: PGII
-Eye Irritation
-EXPERT JUDGEMENT: Classified 8.3A on the basis of the 8.2B
-Skin Irritation classification.",,"JP_CHRIP, NZ_CCID, US_HSDB",3,OC(=O)CBr,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.492C,J-GLOBAL,O=C(O)CBr,Train,1,2702,training
-"AU_HCIS:
-propionic acid … %
-
-JP_CHRIP:
-Propionic acid
-
-NZ_CCID:
-Propionic acid","JP_CHRIP:
-Ethanecarboxylic acid
-Ethylformic acid
-Methylacetic acid
-Propanoic acid
-
-NZ_CCID:
-Carboxyethane, Ethanecarboxylic acid, Ethylformic acid, Luprosil, Metacetonic acid, Methyl acetic acid, Methylacetic acid, Monoprop, Propanoic acid, Prozoin, Pseudoacetic acid",79-09-4,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3694
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2083e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/790EA423-1E34-4175-A6F2-661589F53EAA","JP_CHRIP:
-Since after application of 0.5 mL of the undiluted liquid of this substance to guinea pigs, mild to moderate edema, moderate to severe erythema and necrosis were observed at 2 hours after application, and necrosis was observed after 24 and 48 hours, it is considered to be corrosive (SIDS (2008)). In addition, there is a report that necrosis was observed after non-occlusive application of 0.01 mL of the undiluted liquid of this substance to rabbits for 24 hours (SIDS (2008), ACGIH (7th, 2001), PATTY (6th, 2012)). From the above results, it was classified in Category 1. Besides, this substance was classified as ""C; R34"" in the EU DSD classification, and as ""Skin Corr. 1B H314"" in the EU CLP classification.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Irritating
-REFERENCE SOURCE: BASF AG Ludwigshafen(86)(86) Loden M. et al.: FOA Rept E40023, Natl. Environ. Protect. Board, Sweden, (1985), zitiert in Bibra (1991) [IUCLID 2000]
-REMARK: Mild
-Skin Irritation was seen following 4 h closed contact of the skin with a 2.5 % aqueous solution, mild to moderate irritation occurred with 25 % solutions, while moderate to severe irritation and corrosion were seen at concentrations of 40 % and above.
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Corrosive
-REFERENCE SOURCE: Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986. 767 **PEER REVIEWED** [HSDB]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CCC(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.963A,J-GLOBAL,CCC(=O)O,Train,1,2702,training
-"AU_HCIS:
-acrylic acid
-
-EU_REACH:
-prop-2-enoic acid
-
-JP_CHRIP:
-Acrylic acid
-
-KR_NCIS:
-2-Propenoic acid; Acrylic acid
-
-NZ_CCID:
-Acrylic acid
-
-US_HSDB:
-Acrylic acid","AU_HCIS:
-prop-2-enoic acid
-2-Propenoic acid
-acroleic acid
-glacial acrylic acid
-ethylenecarboxylic acid
-
-JP_CHRIP:
-2-Propenoic acid
-Acroleic acid
-Ethylenecarboxylic acid
-
-NZ_CCID:
-2-Propenoic acid, Acroleic acid, Ethylenecarboxylic acid, Propenoic acid, Vinylformic acid",79-10-7,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=93
-EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15803/7/4/2/?documentUUID=a3ed58c4-466a-4606-8160-ab9d148aa4bf
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2001e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7F31379C-2C49-40F3-91B3-1606459E1E24
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1421","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-There is a report that in a skin irritation test (OECD TG compliant) in which the undiluted liquid of this substance was applied semi-occlusively to rabbits for 3 minutes, superficial necrosis, slight edema, and discoloration were observed, and on histopathological examination, deep focal necrosis and loss of epidermal adnexa in the necrosis area, and perifocal moderate epithelial hyperplasia and diffuse inflammatory reaction were observed in the application area (EU-RAR (2002)). In addition, there is a report that as a result of a 1-minute application of the undiluted liquid of this substance to rabbits, a corrosive reaction was observed (EU-RAR (2002), ECETOC JACC (1995)). Moreover, in humans, 2 workers needed hospitalisation because of skin corrosion during 1967-1992 (EU-RAR (2002)). Based on the above results, it was classified in Category 1A. Besides, it was classified as ""C, R35"" in the EU DSD classification, and ""Skin Corr. 1A, H314"" in the EU CLP classification.
-
-NZ_CCID:
-Skin Irritation
-R- PHRASE: R 35 Causes severe burns.
-[ec classification]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Concentrated ""glacial"" acrylic acid...caused injury graded 9 on a scale with the maximum of 10 (10 being the most severe).
-REFERENCE SOURCE: Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986. 51. [hsdb]",Provided,"AU_HCIS, EU_REACH, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",6,OC(=O)C=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.493A,J-GLOBAL,C=CC(=O)O,Train,1,2702,training
-"AU_HCIS:
-chloroacetic acid
-
-JP_CHRIP:
-Chloroacetic acid [monochloroacetic acid]
-
-KR_NCIS:
-Chloroacetic acid
-
-NZ_CCID:
-Chloroacetic acid
-
-US_HSDB:
-Chloroacetic acid","JP_CHRIP:
-Chloroethanoic acid
-MCA
-Monochloroacetic acid
-
-KR_NCIS:
-Chloracetic acid; alpha-Chloroacetic acid; Chloroethanoic acid; MCA; MCAA; MKhUK; Monochloroacetic acid; Monochloroethanoic acid; Acetic acid, chloro-
-
-NZ_CCID:
-Acetic acid, chloro-, Chloracetic acid, Chloroethanoic acid, Monochloracetic acid, Monochloroacetic acid, Monochloroethanoic acid",79-11-8,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=911
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0051e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9160B2E8-2CA2-496B-9884-80C5FA0A321D
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/939","JP_CHRIP:
-This substance is strongly acidic (pH <1 at 800g/L, 20 degrees C, GESTIS (Access on July 2015)). It is reported that in a skin irritation test using rabbits that 2 animals died after 24-hour occlusive application with 500 mg, and severe erythema and edema were observed, and a primary dermal irritation index was 7.66 (maximum 8) (ECETOC JACC 38 (1999)), and it is reported that after 0.5 mL of a 75% solution of this substance was applied, necrosis was observed after 30 seconds (SIDS (2009)). Besides these, corrosion is reported in an application of this substance in a test using rats or mice (EU-RAR (2005); Initial Risk Assessment, NITE (2008)). Moreover, in multiple accidental contacts in humans, it is reported that chemical burns occurred (EU-RAR (2005); Initial Risk Assessment, NITE (2008)). From the above, because necrosis was observed 30 seconds after application in rabbits, the substance was classified in Category 1A. Besides, it is classified in ""Skin. Corr. 1B H314"" in EU CLP classification (ECHA CL inventory (Access on September 2015)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,OC(=O)CCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.409K,J-GLOBAL,O=C(O)CCl,Train,1,2702,training
-"NZ_CCID:
-Triphenylsilanol",,791-31-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9DE52B0A-6072-4B96-A543-DC4F07741300,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)[Si](C2=CC=CC=C2)(C3=CC=CC=C3)O,https://pubchem.ncbi.nlm.nih.gov/compound/69925,PubChem,O[Si](c1ccccc1)(c1ccccc1)c1ccccc1,Train,1,2702,training
-"JP_CHRIP:
-Hydroxyacetic acid
-
-NZ_CCID:
-Glycolic acid
-
-US_HSDB:
-HYDROXYACETIC ACID","JP_CHRIP:
-Acetic acid, hydroxy-
-Alpha-hydroxyacetic acid
-Glycolic acid
-hydroxyacetic acid
-Hydroxyethanoic acid",79-14-1,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0051e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/08614520-C000-418C-8BBA-8D63504D958E
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/5227","JP_CHRIP:
-In skin irritation tests with rabbits on this substance of purity 99% (cosmetic grade) and a 70% aqueous solution of this substance (technical grade) (tests according to OECD TG404 or similar protocols, GLP-compliant), visible necrosis through the epidermis and into the dermis was observed after a 1-hour application, and it was judged as corrosive (NICNAS (2000)). Therefore, it was classified in Category 1B. Besides, the pH of a 70% aqueous solution of this substance was < 0.5 (NICNAS (2000)).
-
-NZ_CCID:
-Skin Irritation
-REMARK: Solutions containing 30%, 50% and 70% cosmetic grade glycolic acid at their natural pH and a 70% solution adjusted to pH 3 were assigned to Packing Group II (moderate corrosives).
-REFERENCE SOURCE: [NICNAS Priority Existing Chemical Assessment Report No. 12]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: A solution containing 64% glycolic acid (pH not reported) caused severe, irreversible effects including total blindness and was classified as corrosive.
-REFERENCE SOURCE: (DuPont, 1977). [NICNAS Priority Existing Chemical Assessment Report No. 12]",Provided,"JP_CHRIP, NZ_CCID, US_HSDB",3,OCC(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.494J,J-GLOBAL,O=C(O)CO,Train,1,2702,training
-"EU_REACH:
-N-methylacetamide",,79-16-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26228/7/4/2/?documentUUID=4f8331e4-3ec2-4692-b8d8-6d8e471fd4ba,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)NC,https://pubchem.ncbi.nlm.nih.gov/compound/6582,PubChem,CNC(C)=O,Train,1,2702,training
-"AU_HCIS:
-peracetic acid . . . %
-
-JP_CHRIP:
-Peroxyacetic acid","AU_HCIS:
-peroxyacetic acid
-acetic peroxide
-acetyl hydroperoxide
-estosteril
-
-JP_CHRIP:
-Acetyl hydroperoxide
-Ethaneperoxoic acid",79-21-0,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3414
-JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2032.html","JP_CHRIP:
-【分類根拠】
-（１）～（３）より、区分1Aとした。なお、新たな知見に基づき、分類結果を変更した。
-
-【根拠データ】
-（１）本物質0.013％～0.34％溶液は非刺激性～軽度の刺激性物質であるが、3.4％以上の濃度で45分間以上適用した場合、ウサギの皮膚に腐食性影響を示した。5％溶液を3分間適用した場合は中程度～重度の刺激性がみられ、10％～40％溶液では3分以内に腐食性影響を示した（SIAR (2008)、AICIS IMAP (2013)）。
-（２）ウサギを用いた皮膚刺激性試験（3分間適用、本物質10％溶液）において、腐食性影響がみられたとの報告がある（SIAR (2008)、AICIS IMAP (2013)）。
-（３）ウサギを用いた皮膚刺激性試験（3分間適用、本物質15％溶液）において、腐食性影響がみられたとの報告がある（SIAR (2008)、AICIS IMAP (2013)）。",,"AU_HCIS, JP_CHRIP",2,CC(=O)OO,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.833I,J-GLOBAL,CC(=O)OO,Train,1,2702,training
-"JP_CHRIP:
-methyl chloroformate
-
-NZ_CCID:
-Methyl chloroformate","JP_CHRIP:
-Carbonochloridic acid, methyl ester
-chloroformic acid methyl ester
-Methoxycarbonyl chloride
-Methyl chlorocarbonate",79-22-1,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0008e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/61ECBDB5-56E6-404E-956B-B219B79EC6DD","JP_CHRIP:
-The substance was classified into Category 1 since the substance caused damage to skin, and its contact to eyes and skin was highly irritating or corrosive in guinea pig studies (PATTY (5th 2001)). Similarly, the substance is reported to be a highly corrosive irritant according to HSDB (2002); and it is rated R34 in EU classification.
-
-NZ_CCID:
-Skin Irritation
-UN CLASS: 8, PG I.
-Eye Irritation
-UN CLASS: 8, PG I.",,"JP_CHRIP, NZ_CCID",2,COC(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.836I,J-GLOBAL,COC(=O)Cl,Train,1,2702,training
-"NZ_CCID:
-Isobutyryl chloride",,79-30-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/02A72A25-6955-4F07-8B2E-D35D8101D981,"NZ_CCID:
-Skin Irritation
-UN #2353 UN CLASS: 8; PG II
-Eye Irritation
-R PHRASE: R 35 [Company Data]
-UN #2353 UN CLASS: 8 PG II",,NZ_CCID,1,CC(C)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/62325,PubChem,CC(C)C(=O)Cl,Train,1,2702,training
-"EU_REACH:
-2-methylpropanoic acid
-
-JP_CHRIP:
-2-Methylpropionic acid
-
-NZ_CCID:
-Propanoic acid, 2-methyl-","JP_CHRIP:
-2-Methylpropanoic acid
-Dimethylacetic acid
-Propionic acid, 2-methyl-
-
-NZ_CCID:
-2-Methylpropanoic acid, 2-Methylpropionic acid, Dimethylacetic acid, I-Butyric acid, Isobutanoic acid, Isobutyric acid, Isopropylformic acid, iso-Butyric acid",79-31-2,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14591/7/4/2/?documentUUID=a09fc7c1-3520-4e26-9032-37c607c255e0
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0073e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F35B0457-9AFA-49DB-9A94-8B4CE7090AA0","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-Based on a result of ""caused some necrosis within 24-hour"" in skin irritation test (open) with rabbits (PATTY (5th, 2001)) and a report of corrosive in rabbit test (IUCLID (2000)), the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Corrosive
-REFERENCE SOURCE: BASF AG Ludwigshafen
-Hoechst AG Frankfurt/Main (29) BASF AG; Abteilung Toxikologie; Unveroeffentlichte Untersuchung (XXIII/273), 19.04.74 [iuclid 2000}
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Rated 9 on a scale of 1-10, paying particular attention to condition of cornea, most severe injuries rated 10.
-REFERENCE SOURCE: [Peer Reviewed] [Grant, W. M. Toxicology of the Eye. 2nd ed. Springfield, Illinois: Charles C. Thomas, 1974. 1166] [HSDB]",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,CC(C)C(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.840G,J-GLOBAL,CC(C)C(=O)O,Train,1,2702,training
-"EU_REACH:
-(2S)-2-hydroxypropanoic acid
-
-JP_CHRIP:
-L-Lactic acid
-
-NZ_CCID:
-(S)-2-Hydroxypropanoic acid","JP_CHRIP:
-(S)-2-Hydroxypropionic acid
-DL-lactic acid
-L-Lactic acid",79-33-4,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14252/7/4/2/?documentUUID=c84f268b-9269-4502-b486-f5ed9ee9b3ad
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0140e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A33371AB-A87C-4F02-8041-F4FA667EAEB9","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-Since a dermal irritation test (OECD TG 404) using rabbits with this substance indicated severe irritation, and it was corrosive (SIAP (2011)), it was classified in Category 1.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: rabbit
-RESULT: corrosive
-RELIABILITY (KLIMISCH SCORE): 1 (OECD 404, GLP, 1983 and 1986)
-Eye Irritation
-SPECIES: chicken eye (the Enucleated Eye Test with chicken eyes (CEET))
-RESULT:
-Cornea score: 3 (mean; 180 and 240 minutes) (max. 4)
-Remarks: corneal swelling could not be measured at 30, 75 and 120 minutes time interval due to severe to complete corneal opacity
-Opacity: 4 (mean; 30, 75, 120, 180, 240 minutes) (max. 4)
-Fluorescein: 4 (mean; 30 minutes) (max. 4)
-Remarks: Fluorescein retention was only scored at 30 minutes after treatment
-RELIABILITY (KLIMISCH SCORE): 2 (according to guideline, 1996, GLP)",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,C[C@H](O)C(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J9.134K,J-GLOBAL,C[C@H](O)C(=O)O,Train,1,2702,training
-"JP_CHRIP:
-1,1,2,2-Tetrachloroethane (Acetylene tetrachloride)
-
-NZ_CCID:
-Ethane, 1,1,2,2-tetrachloro-","JP_CHRIP:
-1,1,2,2-Tetrachloroethane
-1,1,2,2-Tetrachloroethane; Acethylene tetrachloride
-1,1-Dichloro-2-2,dichloroethane
-Acetylene tetrachloride
-sym-Tetrachloroethane
-
-NZ_CCID:
-Acetylene tetrachloride, Bonoform, R130, Tetrachloroethane",79-34-5,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2066e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5FA9BE64-30AA-4B3F-A727-09C9C0CB0666","JP_CHRIP:
-There is a report that it showed severe irritation with the primary skin irritation index of 6 (maximum value of 8) when 0.01 mL of the undiluted liquid of this substance was applied by open patch to the skin of rabbits for 24 hours (SIDS (2005)). In addition, in other tests with rabbits, there is a report that hyperemia, edema and severe blisters were observed (ATSDR (2008)), and there is a report that since erythema was observed, and the skin primary irritation score was 2.6 (maximum value of 8), it was moderately irritating (IUCLID (2000)). From the above results, it was classified in Category 2.
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Moderately irritating.
-SOURCE: Atochem Paris la Defense (55) Truhaut et al., Arch. Mal. Prof. 1974, 35, 593-608 [IUCLID 2000]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Irritating
-REFERENCE SOURCE: Atochem Paris la Defense
-(55) Truhaut et al., Arch. Mal. Prof. 1974, 35, 593-608 [IUCLID 2000]
-REMARK: EC Classification: Irritating.",,"JP_CHRIP, NZ_CCID",2,ClC(Cl)C(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J43.353E,J-GLOBAL,ClC(Cl)C(Cl)Cl,Train,1,2702,training
-"NZ_CCID:
-(9Z,12Z,15Z)-9,12,15-Octadecatrienamide",,79356-91-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E69CC93B-A4C4-427A-A9B5-AD76988983DB,,,NZ_CCID,1,CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/9882094,PubChem,CC/C=C\C/C=C\C/C=C\CCCCCCCC(N)=O,Train,1,2702,training
-"JP_CHRIP:
-dichloroacetyl chloride
-
-NZ_CCID:
-Dichloroacetyl chloride","JP_CHRIP:
-Dichloroacetyl chloride",79-36-7,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0073e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/31A12432-753D-41E2-89CE-B6E878A14A69","JP_CHRIP:
-It has been documented that in an irritation test using rabbits in which 2 mg of the substance was applied to the skin for 24 hours, the substance was severely irritating (RTECS (2007)). Also, in cases of humans, it has been documented to be a strong irritant to skin and eyes (HSDB (2003)). Thus, the substance was classified into Category 1.
-
-NZ_CCID:
-Skin Irritation
-UN # 765 UN CLASS: 8 PG II
-Eye Irritation
-R PHRASE: R 35 [Company Data]
-UN # 765 UN CLASS: 8 PG II",,"JP_CHRIP, NZ_CCID",2,ClC(Cl)C(=O)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.841E,J-GLOBAL,O=C(Cl)C(Cl)Cl,Train,1,2702,training
-"NZ_CCID:
-Oxalyl chloride",,79-37-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9B6BA50A-3539-4AC1-9EB6-24FC5DD1EE8E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(=O)(C(=O)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/65578,PubChem,O=C(Cl)C(=O)Cl,Train,1,2702,training
-"JP_CHRIP:
-Methacrylamide","JP_CHRIP:
-2-Methylprop-2-enamide",79-39-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0071e.html,"JP_CHRIP:
-There were two test data in conformity with OECD TG 404 and GLP. In the first test, slight erythema in all 3 rabbits was reported after patch removal, but symptoms were reversible after 24 hours. The primary irritation index score was 0.0 and resulted as ""not irritating"" (SIDS (Access on Jul. 2010)). In the second study, slight to well defined erythema was noted in all 3 rabbits after patch removal, and very slight edema was noted in 1 animal. These symptoms recovered within 7 days. The primary irritation index score was 1.11 and resulted as ""slightly irritating"" (SIDS (Access on Jul. 2010)). Based on the information, the substance was classified as ""Not classified"".",Provided,JP_CHRIP,1,CC(=C)C(=O)N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J38.885H,J-GLOBAL,C=C(C)C(N)=O,Train,1,2702,training
-"AU_HCIS:
-methacrylic acid
-
-JP_CHRIP:
-Methacrylic acid
-
-NZ_CCID:
-2-Propenoic acid, 2-methyl- (stabilised), (methacrylic acid)","AU_HCIS:
-2-methylpropenoic acid
-2-Propenoic acid, 2-methyl-
-
-JP_CHRIP:
-2-Methylpropenoic acid
-2-Prop-2-enoic acid
-alpha-Methylacrylic acid
-
-NZ_CCID:
-2-Methyl-2-propenoic acid, 2-Methylacrylic acid, 2-Methylpropenoic acid, 2-Propenoic acid, 2-methyl-, Methacrylic Acid, alpha-Methylacrylic acid",79-41-4,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=2842
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2035e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/21EA3B75-4390-4764-85E5-6C6D9907EFD5","JP_CHRIP:
-There is a report that in a skin irritation test with rabbits (compliant with Confirmation test in the US Department of Transportation Packing Group classification), corrosivity was observed on observation immediately after a test in which undiluted liquid of this substance was openly applied for 3 minutes, followed by wiping away with a water-impregnated paper towel (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)). Therefore, this substance was classified in Category 1A based on the criteria of sub-categories. Besides, this substance is classified as ""Skin Corr. 1A"" in EU CLP classification (ECHA CL Inventory (Access on June 2017)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Highly corrosive
-REFERENCE SOURCE: Degussa AG Frankfurt am Main (148) Rohm & Haas, unpublished report,
-Skin Irritation study in rabbits, Report No. 96R-132, 1996.*
-[IUCLID 2000]
-REMARK: EC Classification: Highly corrosive (causes severe burns).
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Corrosive
-REFERENCE SOURCE: Source: Degussa AG Frankfurt am Main (145) Elf Atochem: Acide Methacrylique (AMA) irritation studies in the rabbit. Consultox Laboratories Limited, report no. CL80:62:2027 (1980). [IUCLID 2000]
-REMARK: EC Classification: Risk of serious damage to eyes.",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CC(=C)C(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.843A,J-GLOBAL,C=C(C)C(=O)O,Train,1,2702,training
-"NZ_CCID:
-2-Mercaptopropionic acid","NZ_CCID:
-thiolactic acid",79-42-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B232771A-FBBA-499E-AC11-11F62679AF5C,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C(=O)O)S,https://pubchem.ncbi.nlm.nih.gov/compound/62326,PubChem,CC(S)C(=O)O,Train,1,2702,training
-"JP_CHRIP:
-Dichloroacetic acid
-
-KR_NCIS:
-Dichloroacetic acid ; DCA
-
-NZ_CCID:
-Dichloroacetic acid
-
-US_HSDB:
-Dichloroacetic acid","JP_CHRIP:
-2,2-Dichloroacetic acid
-Bichloroacetic acid
-DCA
-Dichlorethanoic acid
-
-KR_NCIS:
-DCA",79-43-6,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0043e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5CB9355F-A549-41F6-9539-363700D75AB5
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/6894","JP_CHRIP:
-It is written that irritation was observed after the application of 10 mg this substance in rabbits (ACGIH (7th, 2005)) and that severe irritation was found after the 24-hour application of 2 mg this substance (ACGIH (7th, 2005)). Moreover, it is not specific information, but it is written that this substance is corrosive to the skin (Result of the initial environmental risk assessment of chemicals, Vol. 5, Ministry of the Environment in Japan, Tentative hazard assessment sheet (2006); GESTIS (Access on July 2015)). Furthermore, this substance is classified in ""Skin. Corr. 1A H314"" in EU CLP classification (ECHA CL inventory (Access on September 2015)). From the above, it was classified in Category 1.
-
-NZ_CCID:
-Skin Irritation
-UN #1764 UN CLASS: 8; PG II
-Eye Irritation
-R PHRASE: R 35 [Company Data]",,"JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",4,OC(=O)C(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.834G,J-GLOBAL,O=C(O)C(Cl)Cl,Train,1,2702,training
-"EU_CLP:
-dimethylcarbamoyl chloride",,79-44-7,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CN(C)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/6598,PubChem,CN(C)C(=O)Cl,Test,1,2702,training
-"NZ_CCID:
-Pempidine",,79-55-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/154D9707-676F-4E30-9873-F340AD3656A9,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CC1(CCCC(N1C)(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6603,PubChem,CN1C(C)(C)CCCC1(C)C,Train,1,2702,training
-"EU_REACH:
-2-Naphthalenecarboxamide, N,N'-(2,5-dimethyl-1,4-phenylene)bis[4-[2-(5-chloro-2-methylphenyl)diazenyl]-3-hydroxy-",,79665-24-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10328/7/4/2/?documentUUID=9f9c4352-bd09-478d-bb5e-effb60cf28af,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)Cl)N=NC2=C(C(=CC3=CC=CC=C32)C(=O)NC4=CC(=C(C=C4C)NC(=O)C5=CC6=CC=CC=C6C(=C5O)N=NC7=C(C=CC(=C7)Cl)C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/174176,PubChem,Cc1ccc(Cl)cc1N=Nc1c(O)c(C(=O)Nc2cc(C)c(NC(=O)c3cc4ccccc4c(N=Nc4cc(Cl)ccc4C)c3O)cc2C)cc2ccccc12,Train,1,2702,training
-"AU_HCIS:
-3-Buten-2-one, 4-(2,5,6,6-tetramethyl-2-cyclohexen-1-yl)-",,79-69-6,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5896,,,AU_HCIS,1,CC1CC=C(C(C1(C)C)/C=C/C(=O)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/5371002,PubChem,CC(=O)/C=C/C1C(C)=CCC(C)C1(C)C,Train,1,2702,training
-"AU_HCIS:
-3-Buten-2-one, 4-(2,5,6,6-tetramethyl-1-cyclohexen-1-yl)-",,79-70-9,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5897,,,AU_HCIS,1,CC1CCC(=C(C1(C)C)/C=C/C(=O)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/5375215,PubChem,CC(=O)/C=C/C1=C(C)CCC(C)C1(C)C,Train,1,2702,training
-"AU_HCIS:
-3-Buten-2-one, 4-(2,2-dimethyl-6-methylenecyclohexyl)-",,79-76-5,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5898,,,AU_HCIS,1,CC(=O)/C=C/C1C(=C)CCCC1(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/5363741,PubChem,C=C1CCCC(C)(C)C1/C=C/C(C)=O,Train,1,2702,training
-"AU_HCIS:
-1,6-Heptadien-3-one, 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)-",,79-78-7,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5900,,,AU_HCIS,1,CC1=CCCC(C1/C=C/C(=O)CCC=C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/5365976,PubChem,C=CCCC(=O)/C=C/C1C(C)=CCCC1(C)C,Train,1,2702,training
-"AU_HCIS:
-3-Buten-2-one, 3-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-",,79-89-0,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5901,,,AU_HCIS,1,CC1=C(C(CCC1)(C)C)C=C(C)C(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/97996,PubChem,CC(=O)C(C)=CC1=C(C)CCCC1(C)C,Train,1,2702,training
-"JP_CHRIP:
-Camphene (mixed optical isomers)","JP_CHRIP:
-2,2-Dimethyl-3-methylene-norborane
-2,2-Dimethyl-3-methylenebicyclo(2.2.1)heptane
-Bicyclo(2.2.1)heptane, 2,2-dimethyl-3-methylene
-Bicyclo[2.2.1]heptane, 2,2-dimethyl-3-methylene-
-Camphene",79-92-5,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0029e.html,"JP_CHRIP:
-It was classified as ""Not classified"" because it was judged as no irritation in a test by a 4-hour application to the rabbit skin (OECD TG404, GLP) (SIDS (Access on June 2012)). Besides, it is reported that it was slightly irritating after a 24-hour occlusive application of undiluted this substance to the rabbit skin (HSDB (2004)), and in humans, it is reported that 4% of this substance in petrolatum produced no irritation after a 48-hour occlusive application (PATTY (5th, 2001)).",Provided,JP_CHRIP,1,CC1(C)C2CCC(C2)C1=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J39.020H,J-GLOBAL,C=C1C2CCC(C2)C1(C)C,Train,1,2702,training
-"EU_REACH:
-4,4'-isopropylidenedicyclohexanol",,80-04-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11451/7/4/2/?documentUUID=83a740e6-3d62-4227-b746-069d620c6c67,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C1CCC(CC1)O)C2CCC(CC2)O,https://pubchem.ncbi.nlm.nih.gov/compound/94932,PubChem,CC(C)(C1CCC(O)CC1)C1CCC(O)CC1,Train,1,2702,training
-"JP_CHRIP:
-Bisphenol A","JP_CHRIP:
-2,2-bis(4-hydroxyphenyl)propane
-4,4'-(1-Methylethylidene)bisphenol
-4,4'-isopropylidenediphenol
-Bisphenol A
-4,4'-(Propane-2,2-diyl)diphenol",80-05-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0123e.html,"JP_CHRIP:
-Because in the result of a skin irritation test using rabbits (4-hour application, OECD TG 404), skin irritation was not observed (DFGOT suppl (2011), EU-RAR (2010)), it was classified as ""Not classified.""",Provided,JP_CHRIP,1,CC(C)(c1ccc(O)cc1)c1ccc(O)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.531I,J-GLOBAL,CC(C)(c1ccc(O)cc1)c1ccc(O)cc1,Train,1,2702,training
-"EU_REACH:
-3-[(7Z)-pentadec-7-en-1-yl]phenol; 3-[(7Z,10Z)-pentadeca-7,10,14-trien-1-yl]phenol; 3-[(7Z,10Z)-pentadeca-7,10-dien-1-yl]phenol; 3-pentadecylphenol",,8007-24-7,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14106/7/4/2/?documentUUID=591953e9-12cb-4577-a6d0-faf2e6568530,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCC=CCCCCCCCC1=CC(=CC=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/242468,PubChem,CCCCCCC=CCCCCCCCc1cccc(O)c1,Train,1,2702,training
-"JP_CHRIP:
-Dichlorodiphenylsilane
-
-NZ_CCID:
-Diphenyldichlorosilane","JP_CHRIP:
-Dichlorodiphenylsilane",80-10-4,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0052e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DE98D35C-F618-47D0-83BE-F9D203A38109","JP_CHRIP:
-It is described that this substance is a corrosive chemical, contact with skin can cause severe burns leading to permanent damage, and after dermal exposure, dermatitis (red, inflamed skin), severe burns, pain, and shock occur (HSDB (2010)). And it is described that an application of chlorosilanes to rabbits caused necrosis, blistering, and sloughing on the skin (HSDB (2010)). Because the above knowledge means that irreversible damage occurs on the skin on contact with this substance, it was classified in Category 1.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,Cl[Si](Cl)(c1ccccc1)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J54.323C,J-GLOBAL,Cl[Si](Cl)(c1ccccc1)c1ccccc1,Train,1,2702,training
-"AU_HCIS:
-α,α-dimethylbenzyl hydroperoxide
-
-JP_CHRIP:
-1-Methyl-1-phenylethyl hydroperoxide
-
-NZ_CCID:
-Hydroperoxide, 1-methyl-1-phenylethyl 90-98%, cumene 2-10%","AU_HCIS:
-cumene hydroperoxide
-Hydroperoxide, 1-methyl-1-phenylethyl
-
-JP_CHRIP:
-2-Hydroperoxy-2-phenylpropane
-1-methyl-1-phenylethyl hydroperoxide
-2-Phenylpropan-2-yl hydroperoxide
-alpha,alpha-Dimethylbenzyl hydroperoxide
-cumene hydroperoxide
-Cumyl hydroperoxide
-Hydroperoxide, 1-methyl-1-phenylethyl
-
-NZ_CCID:
-Cumene hydroperoxide, Cumyl hydroperoxide",80-15-9,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4748
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2060e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8046C3B7-4928-4A17-89BA-C7E54D1BC850","JP_CHRIP:
-As for skin sensitization tests with rabbits, there is a report that severe irritation and damages were found (DFGOT Vol. 3 (1992)), and a description that severe irritation or corrosivity were observed (PATTY (6th, 2012)), therefore, it was classified in Category 1. Besides, this substance was classified as ""Skin Corr. 1B"" in EU CLP classification (ECHA CL Inventory (Access on June 2017)).
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Corrosive
-REFERENCE SOURCE: Clayton, G.D., F.E. Clayton (eds.) Pattys Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994. 584 **PEER REVIEWED** [HSDB]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: Corrosive
-REFERENCE SOURCE: Grant, W. M. Toxicology of the Eye. 2nd ed. Springfield, Illinois: Charles C. Thomas, 1974. 332 **PEER REVIEWED** [HSDB]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CC(C)(OO)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.835E,J-GLOBAL,CC(C)(OO)c1ccccc1,Train,1,2702,training
-"EU_CLP:
-chlorfenson (ISO); 4-chlorophenyl 4-chlorobenzenesulfonate",,80-33-1,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC(=CC=C1OS(=O)(=O)C2=CC=C(C=C2)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/6635,PubChem,O=S(=O)(Oc1ccc(Cl)cc1)c1ccc(Cl)cc1,Test,1,2702,training
-"JP_CHRIP:
-4-chlorophenyl benzenesulphonate; fenson","JP_CHRIP:
-Fenson",80-38-6,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0074e.html,"JP_CHRIP:
-Since a standard Draize test using rabbits reported that its 24-hour treatment led to mild results (RTECS (1996): 85 JCAE ""Prehled Prumyslove Toxikologie; Organicke Latky,"" Marhold, J., Prague, Czechoslovakia, Avicenum, 1986, 1068, 1986), the substance was classified into Category 2.",,JP_CHRIP,1,Clc1ccc(OS(=O)(=O)c2ccccc2)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.249H,J-GLOBAL,O=S(=O)(Oc1ccc(Cl)cc1)c1ccccc1,Train,1,2702,training
-"EU_CLP:
-bis(α,α-dimethylbenzyl) peroxide",,80-43-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C)(C1=CC=CC=C1)OOC(C)(C)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/6641,PubChem,CC(C)(OOC(C)(C)c1ccccc1)c1ccccc1,Test,1,2702,training
-"JP_CHRIP:
-4-tert-Pentylphenol",,80-46-6,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-0029e.html,"JP_CHRIP:
-Based on descriptions that this substance was corrosive to the skin (EPA Pesticide (2005)), and that this substance was an irritant of Category I (HSDB (Access on August 2017)), it was classified in Category 1.",,JP_CHRIP,1,CCC(C)(C)c1ccc(O)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.250A,J-GLOBAL,CCC(C)(C)c1ccc(O)cc1,Train,1,2702,training
-"EU_CLP:
-8-p-menthyl hydroperoxide; p-menthane hydroperoxide",,80-47-7,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC1CCC(CC1)C(C)(C)OO,https://pubchem.ncbi.nlm.nih.gov/compound/6644,PubChem,CC1CCC(C(C)(C)OO)CC1,Test,1,2702,training
-"JP_CHRIP:
-Methyl p-toluenesulfonate
-
-NZ_CCID:
-Methyl 4-toluenesulphonate","NZ_CCID:
-methyl p-toluenesulfonate",80-48-8,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2029e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/62DEFD33-3E10-47FD-ADE7-6DF703D4D0E9","JP_CHRIP:
-Based on a report that this substance is severely irritating to the skin, it was classified in Category 2 (HSDB (Access on June 2017)). The category was changed by reviewing the information.
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,"JP_CHRIP, NZ_CCID",2,COS(=O)(=O)c1ccc(C)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J54.424H,J-GLOBAL,COS(=O)(=O)c1ccc(C)cc1,Train,1,2702,training
-"AU_HCIS:
-Benzenepropanal, 4-(1,1-dimethylethyl)-.alpha.-methyl-
-
-JP_CHRIP:
-3-(4-tert-Butylphenyl)-2-methylpropanal","AU_HCIS:
-Lilial
-2-(4-tert-butylbenzyl)propionaldehyde
-p-tert-butyl-alpha-methylhydrocinnamic aldehyde
-alpha-methyl-p-(tert-butyl)hydrocinnamaldehyde
-alpha-methyl, beta-(p-tert-butylphenyl)propionaldehyde
-
-JP_CHRIP:
-2-methyl-3-(4-tert-butylphenyl)propionaldehyde",80-54-6,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5553
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-meti-2012e.html","JP_CHRIP:
-[Rationale for the Classification]
-Based on (1) and (2), it was classified in Category 2 according to the GHS Classification Guidance for the Japanese Government. As for (3), it is a result in support of judgment of Category 2 although the test method is not in accordance with OECD TG.
-
-[Evidence Data]
-(1) In a skin irritation test (OECD TG404, GLP-compliant, n = 3) with rabbits, as a result of the semi-occlusive application of the undiluted liquid of this substance for 4 hours, the mean scores at 24-72 hours for erythema and edema were 1.7/2.0/2.3 and 2.0/2.7/3.0, respectively, and the mean erythema and edema scores observed after 7 days were 1.7 and 1.3, respectively (SCCS (2016), NICNAS IMAP (Accessed Dec. 2018), REACH registration dossier (Accessed Dec. 2018), ECETOC TR66 (1995)). In addition, PII (primary irritation index) was 4.56 (ECETOC TR66 (1995)).
-(2) There is a report that in a skin irritation test (equivalent to OECD TG404, GLP-compliant, n = 4) with rabbits, as a result of the semi-occlusive application of the undiluted liquid of this substance for 4 hours, the mean scores at 24-72 hours for erythema and edema were 1.7/2.0/2.0/2.0 and 1.0/1.7/1.7/2.3, respectively, and desquamation after 7 days was observed in all the animals (SCCS (2016), NICNAS IMAP (Accessed Dec. 2018), ECETOC TR66 (1995)). In addition, PII (primary irritation index) was 3.58 (ECETOC TR66 (1995)).
-
-[Reference Data, etc.]
-(3) There is a report that in a skin irritation test (FDA Register 38. No. 187, Para. 1500.41, S27029, n = 2 (5 minutes, or 2-hour application), n = 3 (24-hour application), male (2) female (1)) with rabbits, as a result of the occlusive application of the undiluted liquid of this substance, the mean scores at 24-72 hours for erythema and edema of 2.0 and 1.0 at 5-minute application, 1.0, 2.0 and 1.0, 0.5 at 2-hour application were observed, the animals of the former (5 minutes application) recovered after 8 days, while in 1/2 the animals in the latter (2-hour application), erythema did not resolve, and desquamation of the skin was observed after 8 days in all the animals (REACH registration dossier (Accessed Dec. 2018)).
-(4) There is a report that in a patch test with 25 volunteers (men: 3, women: 22), as a result of 24-hour occlusive application of solutions of this substance (in 75% ethanol/25% diethyl phthalate) at concentrations of 0, 10, 15, 20, 25%, respectively, faint erythema was observed in a few subjects in the case of 10% and 20% solutions, but skin irritation was not observed at the highest concentration, and concentration dependence was not observed (SCCS (2016)).",Provided,"AU_HCIS, JP_CHRIP",2,CC(Cc1ccc(cc1)C(C)(C)C)C=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J11.845A,J-GLOBAL,CC(C=O)Cc1ccc(C(C)(C)C)cc1,Train,1,2702,training
-"AU_HCIS:
-Bicyclo[3.1.1]hept-2-ene, 2,6,6-trimethyl-
-
-JP_CHRIP:
-2,6,6-Trimethylbicyclo[3.1.1]hept-2-ene (alpha-Pinene)
-
-NZ_CCID:
-Bicyclo[3.1.1]hept-2-ene, 2,6,6-trimethyl-","JP_CHRIP:
-alpha-Pinene
-Bicyclo[3.1.1]hept-2-ene, 2,6,6-trimethyl-
-
-NZ_CCID:
-2,6,6-Trimethylbicyclo[3.1.1]hept-2-ene, 2-Pinene",80-56-8,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5929
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0100e.html
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/66E94F78-187D-4108-8C10-D0A0898EC0C5","JP_CHRIP:
-Based on results of ""moderately irritating"" in rabbit tests by dermal application for 4 or 24-hour (Pesticide safety information (Japan Crop Protection Association) vol. 17 (1994), IUCLID (2000)) and a report that primary dermal irritation index was 4.7 in a 4-hour dermal application test (Pesticide safety information (Japan Crop Protection Association) vol. 17 (1994)), the substance was classified as ""Not classified"".
-
-NZ_CCID:
-Skin Irritation
-SPECIES: Rabbit
-RESULT: Moderate
-REFERENCE SOURCE: Food and Cosmetics Toxicology.(London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. (16,853,1978). [RTECS]
-Eye Irritation
-SPECIES:
-RESULT: Irritant
-REFERENCE SOURCE: Lewis, R.J. Saxs Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996. 2707 - HSDB",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,CC1=CCC2CC1C2(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.210G,J-GLOBAL,CC1=CCC2CC1C2(C)C,Train,1,2702,training
-"NZ_CCID:
-2-Bromobutyric acid",,80-58-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9F54251B-45DA-4F47-9D00-6BBA0713F35D,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCC(C(=O)O)Br,https://pubchem.ncbi.nlm.nih.gov/compound/6655,PubChem,CCC(Br)C(=O)O,Train,1,2702,training
-"AU_HCIS:
-methyl methacrylate
-
-JP_CHRIP:
-Methyl methacrylate","AU_HCIS:
-methyl 2-methylprop-2-enoate
-methyl 2-methylpropenoate
-2-Propenoic acid, 2-methyl-, methyl ester
-
-JP_CHRIP:
-Methacrylic acid methyl ester
-Methyl 2-methylpropenoate",80-62-6,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=2920
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2034e.html","JP_CHRIP:
-There are multiple case reports showing skin irritation in humans such as a volunteer test applying paraffin or olive oil containing 5% of this substance, in which erythema and eczematous dermatitis were noted in 18 out of 20 (EU-RAR (2002)). In addition, in a skin irritation test with rabbits, after applying this substance for 4 hours, erythema and oedema scores within 72 hours were 2-2.5, 1.5-1, respectively, and erythema and oedema scores after 7 days were 2, 0.5, respectively (EU-RAR (2002)). Therefore, this substance was classified in Category 2. Besides, this substance was classified as ""Skin Irrit. 2"" in EU CLP classification (ECHA CL Inventory (Access on June 2017)).",,"AU_HCIS, JP_CHRIP",2,COC(=O)C(=C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.532G,J-GLOBAL,C=C(C)C(=O)OC,Train,1,2702,training
-"EU_REACH:
-A mixture of: ethyl exo-tricyclo[5.2.1.02,6]decane-endo-2-carboxylate; ethyl-endo-tricyclo[5.2.1.02,6]decane-exo-2-carboxylate",,80657-64-3,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/28040/7/4/2/?documentUUID=abb2fd24-2f1a-41f8-b752-112068e6b4e9,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)[C@@]12CCC[C@@H]1[C@@H]3CC[C@H]2C3,https://pubchem.ncbi.nlm.nih.gov/compound/157343,PubChem,CCOC(=O)[C@@]12CCC[C@@H]1[C@@H]1CC[C@H]2C1,Train,1,2702,training
-"EU_REACH:
-2-[(1E)-2-(2-methoxy-5-nitrophenyl)diazen-1-yl]-N-(2-methoxyphenyl)-3-oxobutanamide",,80675-49-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10476/7/4/2/?documentUUID=b30f5356-3971-4b08-a577-db20240f2d20,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC=CC=C1OC)N=NC2=C(C=CC(=C2)[N+](=O)[O-])OC,https://pubchem.ncbi.nlm.nih.gov/compound/102295954,PubChem,COc1ccc([N+](=O)[O-])cc1N=NC(C(C)=O)C(=O)Nc1ccccc1OC,Train,1,2702,training
-"NZ_CCID:
-1,1,3,3-tetramethylguanidine","NZ_CCID:
-Guanidine, N,N,N',N'-tetramethyl-",80-70-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E1104A4D-A044-4A1C-848A-A6DE4F85F13E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CN(C)C(=N)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/66460,PubChem,CN(C)C(=N)N(C)C,Train,1,2702,training
-"EU_REACH:
-1,1,1,2,2,3,3,4,4,5,5,6,6-tridecafluorooctane",,80793-17-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7612/7/4/2/?documentUUID=2cb7251a-0fc2-4c16-88aa-6ed513375f1a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/2776163,PubChem,CCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train,1,2702,training
-"KR_NCIS:
-[2-(Cyclohexyloxy)ethyl]benzene",,80858-47-5,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C1CCC(CC1)OCCC2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/166527,PubChem,c1ccc(CCOC2CCCCC2)cc1,Train,1,2702,training
-"EU_REACH:
-1,3-dichloro-2-(dichloromethyl)benzene",,81-19-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12005/7/4/2/?documentUUID=3248af29-9962-4b0a-808e-17c3ae27591a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C(=C1)Cl)C(Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/6671,PubChem,Clc1cccc(Cl)c1C(Cl)Cl,Train,1,2702,training
-"EU_REACH:
-methyl dihydrogen phosphate",,812-00-0,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24818/7/4/2/?documentUUID=bcba15ef-7482-4eb6-afb0-9ae8209b0d91,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COP(=O)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/13130,PubChem,COP(=O)(O)O,Train,1,2702,training
-"EU_REACH:
-2-[4-methyl-5-oxo-4-(propan-2-yl)-4,5-dihydro-1H-imidazol-2-yl]pyridine-3-carboxylic acid
-
-JP_CHRIP:
-(RS)-2-(4-Isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)nicotinic acid (synonym: imazapyr)",,81334-34-1,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21966/7/4/2/?documentUUID=17d6089d-d9d5-4e7f-8149-61bfa83ad3aa
-JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-0025.html","EU_REACH:
-Experimental study (OECD TG 404, GLP)
-
-JP_CHRIP:
-【分類根拠】
-（１）、（２）より、区分に該当しない。
-
-【根拠データ】
-（１）ウサギ（n=3）を用いた皮膚刺激性試験（OECD TG 404、GLP、半閉塞、4時間適用、72時間観察）において、皮膚刺激性はみられなかった（紅斑・痂皮スコア：0/0/0��浮腫スコア：0/0/0）との報告がある（REACH登録情報 (Accessed May 2021)）。
-（２）ウサギ（n=6）を用いた皮膚刺激性試験（72時間観察）において、本物質を有傷皮膚、無傷皮膚に適用したところ、有傷皮膚では24時間後に紅斑がみられたが、72時間以内に回復した。無傷皮膚では24、72時間後に皮膚刺激性反応はみられなかったとの報告がある（食安委 農薬評価書 (2020)、EFSA (2014)、JMPR (2013)、農薬抄録 (2016)）。",Provided,"EU_REACH, JP_CHRIP",2,CC(C)C1(C)N=C(NC1=O)c1ncccc1C(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J43.085D,J-GLOBAL,CC(C)C1(C)N=C(c2ncccc2C(=O)O)NC1=O,Train,1,2702,training
-"NZ_CCID:
-Phosphine oxide, tributyl-",,814-29-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/444CA1FD-703C-430C-AB90-D3B753F8B0A1,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCCCP(=O)(CCCC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/13138,PubChem,CCCCP(=O)(CCCC)CCCC,Train,1,2702,training
-"NZ_CCID:
-Acryloyl chloride
-
-US_HSDB:
-Acrylyl chloride",,814-68-6,Cat 1,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/927AF785-FB58-45D9-B434-B1E15A9469C4
-US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/6330","NZ_CCID:
-Skin Irritation
-R PHRASE: R 35 [Company Data]
-Eye Irritation
-R PHRASE: R 35 [Company Data]",,"NZ_CCID, US_HSDB",2,C=CC(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/13140,PubChem,C=CC(=O)Cl,Train,1,2702,training
-"JP_CHRIP:
-Methyl isopropenyl ketone",,814-78-8,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0004e.html,"JP_CHRIP:
-It was classified in Category 2 because it is reported that it was moderately irritating in a test by occlusive application to the rabbit skin (PATTY (5th, 2001)).",,JP_CHRIP,1,CC(=C)C(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J35.118K,J-GLOBAL,C=C(C)C(C)=O,Train,1,2702,training
-"EU_REACH:
-4-({5-cyano-4-methyl-6-[(4-sulfophenyl)amino]pyridin-2-yl}amino)benzene-1-sulfonic acid",,815676-09-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22281/7/4/2/?documentUUID=c8349557-747d-4810-bec6-ebb41fb62477,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=NC(=C1C#N)NC2=CC=C(C=C2)S(=O)(=O)O)NC3=CC=C(C=C3)S(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/11167833,PubChem,Cc1cc(Nc2ccc(S(=O)(=O)O)cc2)nc(Nc2ccc(S(=O)(=O)O)cc2)c1C#N,Train,1,2702,training
-"EU_CLP:
-methyl 2,2-dimethyl-6-methylenecyclohexanecarboxylate",,81752-87-6,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC1(CCCC(=C)C1C(=O)OC)C,https://pubchem.ncbi.nlm.nih.gov/compound/11095260,PubChem,C=C1CCCC(C)(C)C1C(=O)OC,Test,1,2702,training
-"EU_REACH:
-4-methyldec-3-en-5-ol",,81782-77-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12744/7/4/2/?documentUUID=e7f65251-245d-4c40-849c-1028db866384,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCC(/C(=C/CC)/C)O,https://pubchem.ncbi.nlm.nih.gov/compound/6441135,PubChem,CC/C=C(\C)C(O)CCCCC,Train,1,2702,training
-"EU_CLP:
-2-hydroxyethyl acrylate",,818-61-1,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C=CC(=O)OCCO,https://pubchem.ncbi.nlm.nih.gov/compound/13165,PubChem,C=CC(=O)OCCO,Test,1,2702,training
-"NZ_CCID:
-1,4-Dichloro-2-butyne",,821-10-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7110665B-32A1-455C-991F-F9DC7B26E670,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(C#CCCl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/13182,PubChem,ClCC#CCCl,Train,1,2702,training
-"EU_REACH:
-2-[(1E)-2-(2-methoxyphenyl)diazen-1-yl]-3-oxo-N-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl)butanamide",,82199-12-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5446/7/4/2/?documentUUID=98595a51-8f6b-4a24-9748-0bbe11174160,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC2=C(C=C1)NC(=O)N2)N=NC3=CC=CC=C3OC,https://pubchem.ncbi.nlm.nih.gov/compound/174265,PubChem,COc1ccccc1N=NC(C(C)=O)C(=O)Nc1ccc2[nH]c(=O)[nH]c2c1,Train,1,2702,training
-"EU_CLP:
-hexamethylene-di-isocyanate",,822-06-0,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C(CCCN=C=O)CCN=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/13192,PubChem,O=C=NCCCCCCN=C=O,Test,1,2702,training
-"JP_CHRIP:
-2-methyl-m-phenylene diamine","JP_CHRIP:
-1,3-Diamino-2-methylbenzene
-2,6-Diaminotoluene
-2-Methyl-1,3-benzenediamine
-2-Methyl-m-phenylenediamine
-2-Methylbenzene-1,3-diamine",823-40-5,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/07-meti-0013e.html,"JP_CHRIP:
-Although there is no skin irritation test data of this substance, it has been described that this substance has a ""skin irritation"" in ICSC (2001) or that ""Diaminotoluene irritates skin"" in EHC 74 (1987). It may be classified as Category 2 or Category 3 since it is likely to have an irritation despite its unknown degree. It is classified into Category 2 from a viewpoint of safety. In addition, 2,5-TDA and 2,4-TDA can be classified as Category 3.",,JP_CHRIP,1,Cc1c(N)cccc1N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J7.125K,J-GLOBAL,Cc1c(N)cccc1N,Train,1,2702,training
-"EU_REACH:
-(4E)-3-methylcyclopentadec-4-en-1-one; (5E)-3-methylcyclopentadec-5-en-1-one; (5Z)-3-methylcyclopentadec-5-en-1-one",,82356-51-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16261/7/4/2/?documentUUID=cbb227f1-859f-4e56-87bc-53e7f494d013,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C/C/1=C/CCCCCCCCCCCCC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/92043557,PubChem,C/C1=C/CCCCCCCCCCCCC1=O,Train,1,2702,training
-"NZ_CCID:
-3-Bromobenzyl bromide",,823-78-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/69FA01C0-4A55-441B-AF98-675925FFB27E,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)Br)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/69979,PubChem,BrCc1cccc(Br)c1,Train,1,2702,training
-"NZ_CCID:
-Dichlorophenylphosphine oxide",,824-72-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/78E2D2DC-D3EE-47D2-90BF-C77198CAC8FC,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C(C=C1)P(=O)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/69990,PubChem,O=P(Cl)(Cl)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-3-Methoxybenzyl chloride",,824-98-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8D69766A-B0F4-4FE2-A420-63EB15E4C4F9,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [Company Data]
-Eye Irritation
-R PHRASE: R 34 [Company Data]",,NZ_CCID,1,COC1=CC=CC(=C1)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/69994,PubChem,COc1cccc(CCl)c1,Train,1,2702,training
-"EU_REACH:
-4-chlorobutyl 3-chloropropanoate",,82530-64-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33473/7/4/2/?documentUUID=7a562632-4f5b-40cb-afd5-1f69e1f2afa1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CCCl)COC(=O)CCCl,https://pubchem.ncbi.nlm.nih.gov/compound/11275655,PubChem,O=C(CCCl)OCCCCCl,Train,1,2702,training
-"EU_REACH:
-4-(4-butylphenyl)-4'-ethyl-3-fluoro-1,1'-biphenyl",,825633-75-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21007/7/4/2/?documentUUID=45938635-2d93-4d92-a5fa-5435ab0246f1,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC1=CC=C(C=C1)C2=C(C=C(C=C2)C3=CC=C(C=C3)CC)F,https://pubchem.ncbi.nlm.nih.gov/compound/59734846,PubChem,CCCCc1ccc(-c2ccc(-c3ccc(CC)cc3)cc2F)cc1,Train,1,2702,training
-"EU_REACH:
-4-(butoxymethyl)-2-methoxyphenol",,82654-98-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1538/7/4/2/?documentUUID=b7412d20-feaf-4369-9569-121f177ac77f,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOCC1=CC(=C(C=C1)O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/5084146,PubChem,CCCCOCc1ccc(O)c(OC)c1,Train,1,2702,training
-"NZ_CCID:
-1-Naphthalenesulphonic acid, 8-(phenylamino)-",,82-76-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7DF413A1-7B4E-41A8-95B6-BBBE1B8111A8,,,NZ_CCID,1,C1=CC=C(C=C1)NC2=CC=CC3=C2C(=CC=C3)S(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/1369,PubChem,O=S(=O)(O)c1cccc2cccc(Nc3ccccc3)c12,Train,1,2702,training
-"NZ_CCID:
-Acenaphthenequinone",,82-86-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1582F920-6341-423D-A5B2-964C25F36FFB,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C1=CC2=C3C(=C1)C(=O)C(=O)C3=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/6724,PubChem,O=C1C(=O)c2cccc3cccc1c23,Train,1,2702,training
-"NZ_CCID:
-Diphenylcarbamyl chloride","NZ_CCID:
-N,N-Diphenylcarbamoyl chloride",83-01-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/442EEC7A-9E19-44F6-BF36-77F987A0694B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 41[CHEMWATCH]",,NZ_CCID,1,C1=CC=C(C=C1)N(C2=CC=CC=C2)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/65741,PubChem,O=C(Cl)N(c1ccccc1)c1ccccc1,Train,1,2702,training
-"NZ_CCID:
-Ethanol, 2-((2-(2-(dimethylamino)ethoxy)ethyl)methylamino)-","NZ_CCID:
-2-[(2-[2-(Dimethylamino)ethoxy]ethyl)methylamino]ethanol",83016-70-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8A074045-DADA-4EF7-A963-FD59ABCF5610,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [ECB]
-Eye Irritation
-R PHRASE: R 34 [ECB]",,NZ_CCID,1,CN(C)CCOCCN(C)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/3086157,PubChem,CN(C)CCOCCN(C)CCO,Train,1,2702,training
-"US_HSDB:
-ACENAPHTHENE",,83-32-9,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/2659,,,US_HSDB,1,C1CC2=CC=CC3=C2C1=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/6734,PubChem,c1cc2c3c(cccc3c1)CC2,Train,1,2702,training
-"NZ_CCID:
-2,6-Dichlorobenzaldehyde",,83-38-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C2F5F68D-26E2-4A4E-B503-9049E4FF059F,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C(=C1)Cl)C=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/6737,PubChem,O=Cc1c(Cl)cccc1Cl,Train,1,2702,training
-"EU_REACH:
-naphthalene-1,5-diol",,83-56-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27320/7/4/2/?documentUUID=742c964e-ba81-4252-a40e-2fbc701bebf0,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=C(C=CC=C2O)C(=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/6749,PubChem,Oc1cccc2c(O)cccc12,Train,1,2702,training
-"EU_CLP:
-di-L-para-menthene",,83648-84-4,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC1=CCC(CC1)C(C)CC(C)(C)C2CCC(=CC2)C,https://pubchem.ncbi.nlm.nih.gov/compound/163420288,PubChem,CC1=CCC(C(C)CC(C)(C)C2CC=C(C)CC2)CC1,Test,1,2702,training
-"EU_REACH:
-4-cyanophenyl 4-{[6-(prop-2-enoyloxy)hexyl]oxy}benzoate",,83847-14-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22993/7/4/2/?documentUUID=0ec426dd-564c-43e5-a836-58d277a499e5,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CC(=O)OCCCCCCOC1=CC=C(C=C1)C(=O)OC2=CC=C(C=C2)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/640210,PubChem,C=CC(=O)OCCCCCCOc1ccc(C(=O)Oc2ccc(C#N)cc2)cc1,Train,1,2702,training
-"EU_REACH:
-methyl 4-[(2,5-dichlorophenyl)carbamoyl]-2-nitrobenzoate",,83929-47-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10413/7/4/2/?documentUUID=31bc5513-c8b1-4f6e-8666-16535d2e7d92,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=C(C=C(C=C1)C(=O)NC2=C(C=CC(=C2)Cl)Cl)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/3019490,PubChem,COC(=O)c1ccc(C(=O)Nc2cc(Cl)ccc2Cl)cc1[N+](=O)[O-],Train,1,2702,training
-"NZ_CCID:
-9,10-Phenanthrenequinone","NZ_CCID:
-phenanthrenequinone",84-11-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D3323DB9-AC5E-482E-BA28-3A103C3DDFFB,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C2C(=C1)C3=CC=CC=C3C(=O)C2=O,https://pubchem.ncbi.nlm.nih.gov/compound/6763,PubChem,O=C1C(=O)c2ccccc2-c2ccccc21,Train,1,2702,training
-"NZ_CCID:
-Propoxylated neopentyl glycol diacrylate esters",,84170-74-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B08340DE-5703-4719-B8FD-5F668F8FE7B0,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [CHEMWATCH]
-Eye Irritation
-R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,CC(C)(COCCCOC(=O)C=C)COCCCOC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/174364,PubChem,C=CC(=O)OCCCOCC(C)(C)COCCCOC(=O)C=C,Train,1,2702,training
-"EU_REACH:
-1-(DIPHENYLMETHYL)PIPERAZINE",,841-77-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24243/7/4/2/?documentUUID=27985cb6-78a0-4a4f-9d26-3f5104ca46b4,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CN(CCN1)C(C2=CC=CC=C2)C3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/70048,PubChem,c1ccc(C(c2ccccc2)N2CCNCC2)cc1,Train,1,2702,training
-"EU_REACH:
-2-ethyl-9,10-anthraquinone",,84-51-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14500/7/4/2/?documentUUID=1a1592fb-f49c-48aa-8b1d-f2272d637971,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1=CC2=C(C=C1)C(=O)C3=CC=CC=C3C2=O,https://pubchem.ncbi.nlm.nih.gov/compound/6772,PubChem,CCc1ccc2c(c1)C(=O)c1ccccc1C2=O,Train,1,2702,training
-"EU_REACH:
-3-amino-2-chloro-6-methylphenol",,84540-50-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21096/7/4/2/?documentUUID=a0360467-cd07-4c16-95f3-27880a3e11fb,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(=C(C=C1)N)Cl)O,https://pubchem.ncbi.nlm.nih.gov/compound/157641,PubChem,Cc1ccc(N)c(Cl)c1O,Train,1,2702,training
-"JP_CHRIP:
-9,10-Anthraquinone","JP_CHRIP:
-9,10-Anthracendione
-9,10-Anthracenedione
-anthraquinone
-Diphenyl ketone",84-65-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0053e.html,"JP_CHRIP:
-It was classified as ""Not classified"" because it was not irritating in a skin irritation test with rabbits (OECD TG 404) (IUCLID (2000)). Besides, it is also reported that it was not irritating in another test by a 24-hour semi-occlusive application of 500 microL or 0.5 g to the rabbit skin (IUCLID (2000)).",Provided,JP_CHRIP,1,O=C1c2ccccc2C(=O)c2ccccc12,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J294A,J-GLOBAL,O=C1c2ccccc2C(=O)c2ccccc21,Train,1,2702,training
-"EU_REACH:
-(1r,1's,4r,4'r)-4-(4-methylphenyl)-4'-propyl-1,1'-bi(cyclohexane)",,84656-75-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21867/7/4/2/?documentUUID=2d87d580-c0c5-4780-b008-3fcf2574eae3,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2CCC(CC2)C3=CC=C(C=C3)C,https://pubchem.ncbi.nlm.nih.gov/compound/576378,PubChem,CCCC1CCC(C2CCC(c3ccc(C)cc3)CC2)CC1,Train,1,2702,training
-"JP_CHRIP:
-Diisobutyl phthalate","JP_CHRIP:
-1,2-Benzenedicarboxylic acid, bis-(2-methoxypropyl)ester
-Di(isobutyl)-1,2-benzenedicarboxylate
-DIBP
-Phthalic acic, diisobutyl ester",84-69-5,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-meti-2008e.html,"JP_CHRIP:
-[Rationale for the Classification]
-Based on (1)-(4), it was classified as ""Not classified.""
-
-[Evidence Data]
-(1) There is a report that this substance is not irritating in an in vitro test (OECD TG431, GLP-compliant) (REACH registration dossier (Accessed Dec. 2018)).
-(2) There is a report that in a skin irritation test with rabbits, in which the undiluted liquid of this substance was applied occlusively for 20 hours, after 7 days, the erythema score was 0.5 and the edema score was 0 (REACH registration dossier (Accessed Dec. 2018)).
-(3) There is a report that in a skin irritation test (OECD TG 404, n=3) with rabbits, no irritation was observed when the undiluted liquid of this substance was applied for 4 hours (BUA 201 (1997)).
-(4) There is a report that this substance is not skin irritating (Patty (6th, 2012)).
-
-[Reference Data, etc.]
-(5) There are reports that this substance is not irritating to the skin in rabbits and slightly irritating to the skin in guinea pigs (CPSC (2011)).",Provided,JP_CHRIP,1,CC(C)COC(=O)c1ccccc1C(=O)OCC(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.535A,J-GLOBAL,CC(C)COC(=O)c1ccccc1C(=O)OCC(C)C,Train,1,2702,training
-"JP_CHRIP:
-Di-n-butyl phthalate","JP_CHRIP:
-1,2-Benzenedicarboxylic acid dibutyl ester
-1,2-Benzenedicarboxylic acid, dibutyl ester
-Di-n-butyl phthalate
-dibutyl benzene-1,2-dicarboxylate
-dibutyl phthalate
-Dibutyl phthalate; Dibutyl phthalate
-Dibutyl-1,2-benzenedicarboxylate",84-74-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-2015e.html,"JP_CHRIP:
-It is described in the Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), EU-RAR (2003) that skin irritation was observed, but it is described in EU-RAR (2004) (Addendum to the Environmental Section), which is an addendum to EU-RAR (2003), that a test according to OECD TG404 resulted in no irritation, and it is concluded in EU-RAR (2004) that there was no irritation. Therefore, it was classified as ""Not classified"" (Category 3 in UN GHS classification).",Provided,JP_CHRIP,1,CCCCOC(=O)c1ccccc1C(=O)OCCCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.882B,J-GLOBAL,CCCCOC(=O)c1ccccc1C(=O)OCCCC,Train,1,2702,training
-"EU_REACH:
-(1R,2S,5R)-5-methyl-2-(propan-2-yl)-N-[2-(pyridin-2-yl)ethyl]cyclohexanecarboxamide",,847565-09-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2631/7/4/2/?documentUUID=63dad0b9-5dc4-4559-b9b8-17ea8b2233ae,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H]1CC[C@H]([C@@H](C1)C(=O)NCCC2=CC=CC=N2)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/25126651,PubChem,CC(C)[C@@H]1CC[C@@H](C)C[C@H]1C(=O)NCCc1ccccn1,Train,1,2702,training
-"AU_HCIS:
-4-nonylphenol, branched
-
-JP_CHRIP:
-4-Nonylphenol (branched)
-
-KR_NCIS:
-Nonylphenols
-
-NZ_CCID:
-Nonylphenol, 4-branched","AU_HCIS:
-Phenol, 4-nonyl-, branched
-
-JP_CHRIP:
-4-Nonylphenol, branched
-Branched 4-nonylphenol
-Branched p-nonylphenol; C9 branched alkyl phenol; Nonylphenol; Phenol, 4-nonyl-, branched
-
-KR_NCIS:
-4-Nonylphenol, branched; Branched p-nonylphenol; C9 branched alkyl phenolBranched 4-nonylphenol
-
-NZ_CCID:
-Monononylphenol, Nonanal-methyl anthranilate, Phenol, 4-nonyl-, branched",84852-15-3,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3266
-JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0030e.html
-KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
-NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F94128D9-B89D-4974-93FA-01BF21BDF38B","JP_CHRIP:
-In the rabbit test (OECD TG 404), occlusive administration of 0.5 ml of test substance caused mild to moderate erythema, and mild to moderate edema at 3 minutes of exposure, moderate erythema and severe edema at 4 hours, subsequently, epidermal necrosis, full-thickness skin necrosis, fissure, exfoliation, ulceration, loss of hair, crust formation and cicatrization were observed. The substance was classified as Category 1 since the symptoms were not reversible (Initial Risk Assessment Report (NITE, CERI, NEDO) (2005)).
-
-NZ_CCID:
-Skin Irritation
-R PHRASE: R 34 [NCLASS]
-Eye Irritation
-SPECIES: Rabbit
-RESULT: According to the degree of injury observed after 24 hours have been rated on a scale of 1 to 10 (the most severely injurious substances have been rated 10), a 10.
-REFERENCE SOURCE: Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986. 1047 **PEER REVIEWED** [HSDB]",Provided,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID",4,CC(C)CCCCCCc1ccc(O)cc1,https://cactus.nci.nih.gov/chemical/structure/84852-15-3/smiles,CACTUS,CC(C)CCCCCCc1ccc(O)cc1,Train,1,2702,training
-"EU_REACH:
-2-[[4-(diethylamino)-2-methylphenyl]azo]-5-nitrobenzene-1,3-dicarbonitrile",,84870-65-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21423/7/4/2/?documentUUID=7b9f3905-5769-472a-a721-8af49966f5c7,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(CC)C1=CC(=C(C=C1)N=NC2=C(C=C(C=C2C#N)[N+](=O)[O-])C#N)C,https://pubchem.ncbi.nlm.nih.gov/compound/3020191,PubChem,CCN(CC)c1ccc(N=Nc2c(C#N)cc([N+](=O)[O-])cc2C#N)c(C)c1,Train,1,2702,training
-"NZ_CCID:
-2,6-Difluorophenylacetic acid",,85068-28-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9C4B163C-E8B5-4C28-94F2-06249ECEB66B,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C(=C1)F)CC(=O)O)F,https://pubchem.ncbi.nlm.nih.gov/compound/123585,PubChem,O=C(O)Cc1c(F)cccc1F,Train,1,2702,training
-"AU_HCIS:
-1-Cyclohexene-1-propanal, 4,4-dimethyl-
-
-EU_REACH:
-3-(4,4-dimethylcyclohex-1-en-1-yl)propanal",,850997-10-3,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1113
-EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32359/7/4/2/?documentUUID=51a534d0-4c13-4e43-a058-40e561e4b63b","EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,"AU_HCIS, EU_REACH",2,CC1(CCC(=CC1)CCC=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/22336879,PubChem,CC1(C)CC=C(CCC=O)CC1,Train,1,2702,training
-"EU_REACH:
-1,3,5-triisopropyl-2,4-dinitrobenzene",,85187-23-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11287/7/4/2/?documentUUID=1081bbfe-0c96-407d-ad47-644496acea1a,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1=CC(=C(C(=C1[N+](=O)[O-])C(C)C)[N+](=O)[O-])C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/3020492,PubChem,CC(C)c1cc(C(C)C)c([N+](=O)[O-])c(C(C)C)c1[N+](=O)[O-],Train,1,2702,training
-"US_HSDB:
-Chlorohydroxy benzophenone",,85-19-8,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/2765,,,US_HSDB,1,C1=CC=C(C=C1)C(=O)C2=C(C=CC(=C2)Cl)O,https://pubchem.ncbi.nlm.nih.gov/compound/6799,PubChem,O=C(c1ccccc1)c1cc(Cl)ccc1O,Train,1,2702,training
-"KR_NCIS:
-Bis(1,1-dimethylethyl)[[(trifluoromethyl)sulfonyl]oxy]silyl 1,1,1-trifluoromethanesulfonate",,85272-31-7,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CC(C)(C)[Si](C(C)(C)C)(OS(=O)(=O)C(F)(F)F)OS(=O)(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/545813,PubChem,CC(C)(C)[Si](OS(=O)(=O)C(F)(F)F)(OS(=O)(=O)C(F)(F)F)C(C)(C)C,Train,1,2702,training
-"EU_REACH:
-4-(1-phenylethyl)benzene-1,3-diol",,85-27-8,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11024/7/4/2/?documentUUID=f28b4620-fd19-4c60-9dde-cf8b9452769d,"EU_REACH:
-Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C1=CC=CC=C1)C2=C(C=C(C=C2)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/11171903,PubChem,CC(c1ccccc1)c1ccc(O)cc1O,Train,1,2702,training
-"NZ_CCID:
-Phthalimide",,85-41-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DD7D0500-36C1-435B-A30F-3F774DCB600D,"NZ_CCID:
-Skin Irritation
-R PHRASE: R 38 [Company Data]
-Eye Irritation
-R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C2C(=C1)C(=O)NC2=O,https://pubchem.ncbi.nlm.nih.gov/compound/6809,PubChem,O=C1NC(=O)c2ccccc21,Train,1,2702,training