diff --git "a/AttentiveSkin/AttentiveSkin_test.csv" "b/AttentiveSkin/AttentiveSkin_test.csv"
new file mode 100644--- /dev/null
+++ "b/AttentiveSkin/AttentiveSkin_test.csv"
@@ -0,0 +1,4983 @@
+Name,Synonym,CAS RN,GHS,Detailed Page,Evidence,OECD TG 404,Data Source,Frequency,SMILES,SMILES URL,SMILES Source,Canonical SMILES,Split,ClusterNo,MolCount,group
+"EU_CLP:
+phthalic anhydride",,85-44-9,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC=C2C(=C1)C(=O)OC2=O,https://pubchem.ncbi.nlm.nih.gov/compound/6811,PubChem,O=C1OC(=O)c2ccccc21,Test,1,2702,testing
+"NZ_CCID:
+1-Naphthalenesulphonyl chloride",,85-46-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9A2D4A0C-FC49-45E0-A72F-4F0E34F49525,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [CHEMWATCH]
+Eye Irritation
+R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C2C(=C1)C=CC=C2S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/66560,PubChem,O=S(=O)(Cl)c1cccc2ccccc12,Train,1,2702,testing
+"NZ_CCID:
+1-Naphthalenesulphonic acid, >10% in a non hazardous diluent","NZ_CCID:
+1-naphthalenesulfonic acid",85-47-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CB0D74E8-5160-4ACB-9DE3-CB6FAE99594D,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C2C(=C1)C=CC=C2S(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/6812,PubChem,O=S(=O)(O)c1cccc2ccccc12,Train,1,2702,testing
+"EU_REACH:
+5-hept-6-enyloxolan-2-one",,854737-08-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33826/7/4/2/?documentUUID=fcfe1616-315b-42d9-9865-064e2e03da5d,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CCCCCCC1CCC(=O)O1,https://pubchem.ncbi.nlm.nih.gov/compound/86055585,PubChem,C=CCCCCCC1CCC(=O)O1,Train,1,2702,testing
+"EU_REACH:
+N-(4-chlorophenyl)-4-{2-[2,5-dichloro-4-(dimethylsulfamoyl)phenyl]diazen-1-yl}-3-hydroxynaphthalene-2-carboxamide",,85776-14-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15833/7/4/2/?documentUUID=07c04951-3157-48b0-8d4a-bab2dd3fcced,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C)S(=O)(=O)C1=C(C=C(C(=C1)Cl)N=NC2=C(C(=CC3=CC=CC=C32)C(=O)NC4=CC=C(C=C4)Cl)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/136003704,PubChem,CN(C)S(=O)(=O)c1cc(Cl)c(N=Nc2c(O)c(C(=O)Nc3ccc(Cl)cc3)cc3ccccc23)cc1Cl,Test,1,2702,testing
+"EU_REACH:
+2-(trifluoromethyl)benzenesulfonyl isocyanate",,85813-73-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10851/7/4/2/?documentUUID=bf564dfc-00f2-4653-9afc-7849a031035a,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=C1)C(F)(F)F)S(=O)(=O)N=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/11817579,PubChem,O=C=NS(=O)(=O)c1ccccc1C(F)(F)F,Train,1,2702,testing
+"NZ_CCID:
+Dimethyl anthranilate","NZ_CCID:
+Methyl-N-methyl anthranilate, methyl N-methylanthranilate",85-91-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/21A9689B-AF2F-4E77-8D51-1BC3B266E0F0,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CNC1=CC=CC=C1C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/6826,PubChem,CNc1ccccc1C(=O)OC,Train,1,2702,testing
+"KR_NCIS:
+Tridecylamine, branched and linear",,86089-17-0,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCCC(CC)CCCCCCCN,https://pubchem.ncbi.nlm.nih.gov/compound/22833454,PubChem,CCCC(CC)CCCCCCCN,Train,1,2702,testing
+"EU_REACH:
+2-(2-oxoimidazolidin-1-yl)ethyl methacrylate",,86261-90-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13683/7/4/2/?documentUUID=c01bffd2-ac73-4827-9ed0-e2cc72062696,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=C)C(=O)OCCN1CCNC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/643493,PubChem,C=C(C)C(=O)OCCN1CCNC1=O,Train,1,2702,testing
+"JP_CHRIP:
+N-Nitrosodiphenylamine","JP_CHRIP:
+N,N-Diphenylnitrosoamine
+Diphenylnitrosamine
+n-Nitroso-n-phenyl benzenamine
+n-nitroso-n-phenylaniline
+N-Nitrosodiphenylamine
+Nitrous diphenylamide",86-30-6,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0450e.html,"JP_CHRIP:
+Based on the description in the report on animal skin irritation tests (some details missing such as exposure duration) (ATSDR (1993)): ""The substance produces irritation of the skin"" (though the severity of the effects is unknown). Although classified as Category 2-3, the substance should be placed in Category 2 from the viewpoint of safety.",,JP_CHRIP,1,O=NN(c1ccccc1)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.893H,J-GLOBAL,O=NN(c1ccccc1)c1ccccc1,Train,1,2702,testing
+"EU_CLP:
+2,4-dichloro-5-fluorobenzoylchloride",,86393-34-2,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=C(C(=CC(=C1F)Cl)Cl)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/2736821,PubChem,O=C(Cl)c1cc(F)c(Cl)cc1Cl,Test,1,2702,testing
+"NZ_CCID:
+1-Hydroxy-naphthalene-2-carboxylic acid","NZ_CCID:
+1-hydroxy-2-naphthoic acid",86-48-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0A6F0EDB-1F5E-43DA-83BF-8E78CD6CDC28,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C2C(=C1)C=CC(=C2O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/6844,PubChem,O=C(O)c1ccc2ccccc2c1O,Train,1,2702,testing
+"NZ_CCID:
+1-(Chloromethyl) naphthalene",,86-52-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/607893E1-BDAE-4203-AD22-853C31CE5B76,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C2C(=C1)C=CC=C2CCl,https://pubchem.ncbi.nlm.nih.gov/compound/6845,PubChem,ClCc1cccc2ccccc12,Train,1,2702,testing
+"EU_REACH:
+617-879-7",,865536-03-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21282/7/4/2/?documentUUID=44846f64-ce62-495e-bfbb-3fcf9936bf78,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=CC=C1NC(=O)OCCCCCCCCCCC(C)C)NC(=O)NCC2=CC(=CC=C2)CNC(=O)NC3=C(C(=CC=C3)NC(=O)OCCCCCCCCCCC(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/154734779,PubChem,Cc1c(NC(=O)NCc2cccc(CNC(=O)Nc3cccc(NC(=O)OCCCCCCCCCCC(C)C)c3C)c2)cccc1NC(=O)OCCCCCCCCCCC(C)C,Train,1,2702,testing
+"EU_REACH:
+(3AS,4S,6AR)-4-METHOXYTETRAHYDROFURO[3,4- B]FURAN-2(3H)-ONE",,866594-60-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25324/7/4/2/?documentUUID=97f48c94-4a3a-431e-aced-f6ffeca508c4,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CO[C@@H]1[C@H]2CC(=O)O[C@H]2CO1,https://pubchem.ncbi.nlm.nih.gov/compound/11600708,PubChem,CO[C@H]1OC[C@@H]2OC(=O)C[C@H]12,Train,1,2702,testing
+"NZ_CCID:
+N,N-(1,2-dihydroxyethylene) bisacrylamide",,868-63-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/041FC53C-A01F-4BC4-BF85-05B4F912FF2A,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [CHEMWATCH]
+Eye Irritation
+R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,C=CC(=O)NC(C(NC(=O)C=C)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/102501,PubChem,C=CC(=O)NC(O)C(O)NC(=O)C=C,Train,1,2702,testing
+"ChemSkin:
+Naphthalene acetic acid #",,86-87-3,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
+Experimental study (OECD TG 404)",Provided,ChemSkin,1,C1=CC=C2C(=C1)C=CC=C2CC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/6862,PubChem,O=C(O)Cc1cccc2ccccc12,Test,1,2702,testing
+"EU_CLP:
+2-hydroxyethyl methacrylate",,868-77-9,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(=C)C(=O)OCCO,https://pubchem.ncbi.nlm.nih.gov/compound/13360,PubChem,C=C(C)C(=O)OCCO,Test,1,2702,testing
+"EU_REACH:
+3-methyl-1-p-tolyl-5-pyrazolone",,86-92-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16799/7/4/2/?documentUUID=da18385e-f85c-4410-96e2-1f7b56e7a2e9,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=NN(C(=O)C1)C2=CC=C(C=C2)C,https://pubchem.ncbi.nlm.nih.gov/compound/66591,PubChem,CC1=NN(c2ccc(C)cc2)C(=O)C1,Test,1,2702,testing
+"EU_REACH:
+Benzoic acid, 4-[ (1-oxodecyl) oxy]-",,86960-46-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5452/7/4/2/?documentUUID=ae5e57d1-142b-41de-ab6a-9a19ba0e2a8c,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCC(=O)OC1=CC=C(C=C1)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/3608562,PubChem,CCCCCCCCCC(=O)Oc1ccc(C(=O)O)cc1,Train,1,2702,testing
+"EU_REACH:
+3,3,10,10-tetramethoxy-2,11-dioxa-3,10-disiladodecane",,87135-01-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1492/7/4/2/?documentUUID=cfdfc51e-e9fa-425f-a99b-bb66468020d2,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CO[Si](CCCCCC[Si](OC)(OC)OC)(OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/159046,PubChem,CO[Si](CCCCCC[Si](OC)(OC)OC)(OC)OC,Train,1,2702,testing
+"NZ_CCID:
+Diethyl ethoxymethylenemalonate",,87-13-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/17A87CD8-AE2C-4EA7-8F29-E139F4283C84,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CCOC=C(C(=O)OCC)C(=O)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/6871,PubChem,CCOC=C(C(=O)OCC)C(=O)OCC,Train,1,2702,testing
+"EU_REACH:
+octadecanedioic acid",,871-70-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5505/7/4/2/?documentUUID=c24ff0c1-e46d-468a-b3fe-2ff1df3c125d,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CCCCCCCCC(=O)O)CCCCCCCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/70095,PubChem,O=C(O)CCCCCCCCCCCCCCCCC(=O)O,Train,1,2702,testing
+"NZ_CCID:
+Salicylanilide",,87-17-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9B849B2B-E634-4C04-9375-EA7404EB7A85,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)NC(=O)C2=CC=CC=C2O,https://pubchem.ncbi.nlm.nih.gov/compound/6872,PubChem,O=C(Nc1ccccc1)c1ccccc1O,Train,1,2702,testing
+"JP_CHRIP:
+Dec-1-ene; 1-Decene
+
+NZ_CCID:
+1-Decene","JP_CHRIP:
+1-Decene
+alpha-Decene
+Decylene
+n-1-Decene",872-05-9,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0050e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/241A9146-3A01-41A1-ADD4-1C11CEDCD56A","JP_CHRIP:
+In the Draize test (OECD TG404, GLP-compliant) using rabbit, mean scores of 2.0 for erythema/scab formation and 1.7 for edema, and the primary irritation index (PII) of 3.67 were reported (SIDS (Access on Jun. 2010)). Based on the document, the substance was classified as Category 2. As relevant notes, other Draize test using rabbit, resulted non-irritating based on the PII of 0.9 (SIDS (Access on Jun. 2010)). But the data were derived from an old document in 1967, thus the data obtained in accordance with OECD TG404 and the GLP were used for evaluation.
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]",Provided,"JP_CHRIP, NZ_CCID",2,CCCCCCCCC=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J43.300D,J-GLOBAL,C=CCCCCCCCC,Train,1,2702,testing
+"EU_REACH:
+Bis(2-ethylhexyl) 2-(4-hydroxy-3,5-dimethoxybenzyl)propanedioate",,872182-46-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/4368/7/4/2/?documentUUID=684cac9b-1d6b-4687-ba4e-398a9d852532,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)COC(=O)C(CC1=CC(=C(C(=C1)OC)O)OC)C(=O)OCC(CC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/11961068,PubChem,CCCCC(CC)COC(=O)C(Cc1cc(OC)c(O)c(OC)c1)C(=O)OCC(CC)CCCC,Train,1,2702,testing
+"AU_HCIS:
+2-Pyrrolidinone, 1-methyl-
+
+JP_CHRIP:
+N-Methyl-2-pyrrolidone [N-methylpyrrolidone]
+
+KR_NCIS:
+1-Methyl-2-pyrrolidinone
+
+NZ_CCID:
+2-Pyrrolidinone, 1-methyl-","JP_CHRIP:
+1-Methyl-2-pyrrolidinone
+N-Methyl-2-pyrrolidone
+N-Methylpyrrolidone
+
+KR_NCIS:
+1-Methyl-2-pyrrolidone; 1-Methyl-2-pyrrolidinone; M-Pyrol; 1-Methylpyrrolidin-2-one; N-methylpyrrolidone
+
+NZ_CCID:
+1-Methyl-2-pyrrolidinone, 1-Methyl-2-pyrrolidone, 1-Methylazacyclopentan-2-one, 1-Methylpyrrolidinone, Methylpyrrolidone, N-Methyl-2-pyrrolidinone, N-Methylpyrrolidinone, NMP, m-Pyrol",872-50-4,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=19
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0048e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EA5FC59D-1C1D-4117-9909-FE2F673E77B5","JP_CHRIP:
+It is reported that in a Draize test using rabbits, slight erythema (Draize score: 1) was observed after 24-hour occlusive application of 0.5 mL undiluted this substance (purity > 98 %), and a primary irritation index (PII) was 0.5 (maximum 8) (SIDS (2009), CICAD 35 (2001), DFGOT vol.10 (1998)). On the other hand, severe erythema and scaling were observed after this substance was applied to rabbit skin for 5-15 minutes, and severe edema was found after additional 20-hour application (DFGOT vol.10 (1998), SIDS (2009)). However, In SIDS, this report which is unreliable was not adopted, and it is concluded that this substance is slightly irritating to rabbits (SIDS SIAP (2009)). Moreover, it is reported that slight to moderate transient irritation occurred when 24-hour patch application of this substance to abraded skin of 50 people was done 15 times in total (SIDS (2009), CICAD 35 (2001)). Besides, in occupational exposure, skin signs such as redness and itching were reported in workers handling this substance (Rationale for setting the Recommendation of Acceptable Concentration of the Japan Society for Occupational Health (2002)), but the details such as reversibility are unknown. From the above, although there is the report corresponding to ""Not classified"" in animal tests, because moderate irritation was reported in humans, the substance was classified in Category 2. Besides, it is classified in ""Skin. Irrit. 2 H315"" in EU CLP classification (ECHA CL Inventory (Access on September 2015)).
+
+NZ_CCID:
+Skin Irritation
+SPECIES: Human
+RESULT: Moderately irritating
+REFERENCE SOURCE: ISP Europe GUILDFORD.
+[IUCLID 2000]
+REMARK: EC Classification: Irritating
+R-PHRASE: R 36/38 Irritating to eyes and skin.
+[IUCLID 2000]
+Eye Irritation
+SPECIES: Rabbit
+RESULT: Irritating
+REFERENCE SOURCE: ISP Europe GUILDFORD (121) GAF (1983). [IUCLID 2000]
+REMARK: EC Classification: Irritating
+R-PHRASE: R 36/38 Irritating to eyes and skin.",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID",4,CN1CCCC1=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J26.033I,J-GLOBAL,CN1CCCC1=O,Train,1,2702,testing
+"NZ_CCID:
+Glycol salicylate","NZ_CCID:
+-Hydroxyethyl 2-hydroxybenzoate, Benzoic acid, 2-hydroxy-, 2-hydroxyethyl ester, Ethylene glycol salicylate, Glycol monosalicylate",87-28-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/187895D4-2A7C-4357-857D-F214E46AB9F4,"NZ_CCID:
+Skin Irritation
+Cross referenced from methyl salicylate (Cas No 119-36-8)
+SPECIES: Guinea pig
+RESULT: Highly irritating
+REFERENCE SOURCE: Rhone-Poulenc Chimie Courbevoie Cedex Fassett DW (1963) in Industrial Hygiene an Toxicology 2nd Ed by FA Patty vol. II, p1897 Interscience Publ, NY. In monograph on fragance raw materials. Methyl salicylate OPDYKE, D.L.J. (1987) Food Cosmet. Toxicol 16 (S1) : 821-825 [IUCLID 2000]
+Eye Irritation
+Cross referenced from methyl salicylate (Cas No 119-36-8)
+SPECIES: Rabbit
+RESULT: Irritating
+REFERENCE SOURCE: Rhone-Poulenc Chimie Courbevoie Cedex SAX NI, LEWIS RJ (1992) Dangerous properties of Industrial Materials. Van Nostrand Reinhold, 8th edit. NYork [IUCLID 2000]",,NZ_CCID,1,C1=CC=C(C(=C1)C(=O)OCCO)O,https://pubchem.ncbi.nlm.nih.gov/compound/6880,PubChem,O=C(OCCO)c1ccccc1O,Train,1,2702,testing
+"NZ_CCID:
+Isonicotinaldehyde","NZ_CCID:
+4-pyridinecarboxaldehyde",872-85-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0F49DFCC-A943-4E95-BE6E-3D1542B8052D,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CN=CC=C1C=O,https://pubchem.ncbi.nlm.nih.gov/compound/13389,PubChem,O=Cc1ccncc1,Train,1,2702,testing
+"EU_REACH:
+(4Z)-hept-4-en-2-yl salicylate",,873888-84-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1703/7/4/2/?documentUUID=b81c72b0-8edc-4600-92be-3c0cdb9264a0,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC/C=C\CC(C)OC(=O)C1=CC=CC=C1O,https://pubchem.ncbi.nlm.nih.gov/compound/67480918,PubChem,CC/C=C\CC(C)OC(=O)c1ccccc1O,Train,1,2702,testing
+"NZ_CCID:
+2,4-Dichlorobenzaldehyde",,874-42-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BA184C05-7E4F-49B7-A3F6-C1B0DF99C34C,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C=C1Cl)Cl)C=O,https://pubchem.ncbi.nlm.nih.gov/compound/13404,PubChem,O=Cc1ccc(Cl)cc1Cl,Train,1,2702,testing
+"NZ_CCID:
+4-Toluoyl chloride","NZ_CCID:
+p-toluoyl chloride",874-60-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/826D83EC-F9CE-45C8-A978-BC125BE485DF,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC1=CC=C(C=C1)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/13405,PubChem,Cc1ccc(C(=O)Cl)cc1,Train,1,2702,testing
+"JP_CHRIP:
+Mucochloric acid
+
+NZ_CCID:
+Dichloromalealdehydic acid","JP_CHRIP:
+Mucochloric acid
+
+NZ_CCID:
+mucochloric acid",87-56-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0034e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/83AF56F1-F1C8-451B-9766-5B4DFF295F77","JP_CHRIP:
+In a test by a 4-hour occlusive application of 0.5 g of an 80% aqueous solution of this substance to the skin of two rabbits (Test guidelines of the US Department of Transportation), the average scores after 4 hours, 1 day, 2 days, and 8 days were 3.5, 4, 4, 4, respectively for erythema, and 3, 3, 3, 1.5 for edema, and it was assessed to be corrosive (SIDS (2003)). Therefore, it was classified in Category 1.
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,OC(=O)/C(=C(/Cl)\C=O)/Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.902K,J-GLOBAL,O=C/C(Cl)=C(/Cl)C(=O)O,Train,1,2702,testing
+"AU_HCIS:
+Benzenamine, 2,3-dimethyl-
+
+JP_CHRIP:
+2,3-Dimethylaniline","JP_CHRIP:
+1-Amino-2,3-dimethylbenzene
+2,3-Dimethylaniline
+2,3-Dimethylbenzeneamine
+3-Amino-1,2-xylene
+3-Amino-o-xylene
+Benzenamine, 2,3-dimethyl-",87-59-2,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5304
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0055e.html","JP_CHRIP:
+It was classified in Category 2 because it is reported that severe irritation was observed in a 24-hour occlusive application test with guinea pigs (Hazard Assessment Report Ver. 1.0, No. 208 (CERI, NITE, 2005)), and it is described that this substance and its isomer mixture irritate the skin in humans and may cause erythema and pain on contact with the skin (Environmental Risk Assessment for Chemical Substances vol. 5 (Ministry of the Environment, 2006)).",,"AU_HCIS, JP_CHRIP",2,Cc1cccc(N)c1C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.537H,J-GLOBAL,Cc1cccc(N)c1C,Train,1,2702,testing
+"NZ_CCID:
+2-Amino-6-chlorotoluene","NZ_CCID:
+3-chloro-2-methylaniline",87-60-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/43F73730-E23B-4D93-A04B-EC3DB60420F8,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=C(C=CC=C1Cl)N,https://pubchem.ncbi.nlm.nih.gov/compound/6894,PubChem,Cc1c(N)cccc1Cl,Train,1,2702,testing
+"EU_CLP:
+2,6-xylidine; 2,6-dimethylaniline",,87-62-7,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC1=C(C(=CC=C1)C)N,https://pubchem.ncbi.nlm.nih.gov/compound/6896,PubChem,Cc1cccc(C)c1N,Test,1,2702,testing
+"JP_CHRIP:
+2,6-Dichlorophenol
+
+NZ_CCID:
+2,6-Dichlorophenol","JP_CHRIP:
+Phenol, 2,6-dichloro-",87-65-0,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0056e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E41F2594-3A3A-4D81-A4B7-FA0BB7BBBACE","JP_CHRIP:
+It was classified in Category 2 because it is described that it was a severe skin irritant in humans (HSDB (2009)), and it is reported that there was severe irritation in a test in which 2 mg of this substance was applied to the rabbit skin for 24 hours, although it is List 3 data (RTECS (2011)).
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,"JP_CHRIP, NZ_CCID",2,Oc1c(Cl)cccc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.540H,J-GLOBAL,Oc1c(Cl)cccc1Cl,Train,1,2702,testing
+"EU_REACH:
+(2R,3R)-2,3-dihydroxybutanedioic acid",,87-69-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15126/7/4/2/?documentUUID=b4aed523-b21d-4080-a48f-d6e88c261d06,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,[C@@H]([C@H](C(=O)O)O)(C(=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/444305,PubChem,O=C(O)[C@H](O)[C@@H](O)C(=O)O,Train,1,2702,testing
+"EU_REACH:
+N-{3',4'-dichloro-5-fluoro-[1,1'-biphenyl]-2-yl}acetamide",,877179-03-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29709/7/4/2/?documentUUID=ba837944-2e4e-4950-aa24-41318a3388ae,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)NC1=C(C=C(C=C1)F)C2=CC(=C(C=C2)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/44139270,PubChem,CC(=O)Nc1ccc(F)cc1-c1ccc(Cl)c(Cl)c1,Train,1,2702,testing
+"EU_REACH:
+3',4'-dichloro-5-fluorobiphenyl-2-amine",,877179-04-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8025/7/4/2/?documentUUID=64a20569-b236-4fd4-bd83-b681b09b7437,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C=C1C2=C(C=CC(=C2)F)N)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11572419,PubChem,Nc1ccc(F)cc1-c1ccc(Cl)c(Cl)c1,Train,1,2702,testing
+"EU_REACH:
+(1S)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol",,877397-65-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10776/7/4/2/?documentUUID=fcabcf14-fd44-4b7b-93e0-313b46212807,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H](C1=C(C=CC(=C1Cl)F)Cl)O,https://pubchem.ncbi.nlm.nih.gov/compound/11557536,PubChem,C[C@H](O)c1c(Cl)ccc(F)c1Cl,Train,1,2702,testing
+"EU_REACH:
+5-bromo-3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-amine",,877399-00-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11079/7/4/2/?documentUUID=4983e025-4007-4692-a10b-66797ac54227,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)Br)N,https://pubchem.ncbi.nlm.nih.gov/compound/11689426,PubChem,C[C@@H](Oc1cc(Br)cnc1N)c1c(Cl)ccc(F)c1Cl,Train,1,2702,testing
+"NZ_CCID:
+4-t-Butylbenzyl alcohol","NZ_CCID:
+4-tert-butylbenzyl alcohol",877-65-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AFCB83BE-E013-42BE-82AD-43505E03051B,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 36 [Company Data]
+Eye Irritation
+R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CC(C)(C)C1=CC=C(C=C1)CO,https://pubchem.ncbi.nlm.nih.gov/compound/13416,PubChem,CC(C)(C)c1ccc(CO)cc1,Train,1,2702,testing
+"EU_REACH:
+(1R)-1-[(4R,4aR,8aS)-2,6-bis(4-methylphenyl)-hexahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol",,87826-41-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6843/7/4/2/?documentUUID=e5752db4-0593-43fc-bed7-b6f88bf9714c,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C/C(=C(/O)\[C@H](O)[C@@H](O)[C@H](O)[C@H](O)/C(=C(/C1=CC=CC=C1)\C)/O)/C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/90474944,PubChem,C/C(=C(/O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)/C(O)=C(\C)c1ccccc1)c1ccccc1,Train,1,2702,testing
+"JP_CHRIP:
+Pentachlorophenol","JP_CHRIP:
+Dowicide EC-7(R)
+Pentachlorophenol
+Perchlorophenol
+Phenol, pentachloro-",87-86-5,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2027e.html,"JP_CHRIP:
+[Rationale for the Classification]
+It was classified in Category 2 from (1) - (4).
+
+[Evidence Data]
+(1) Exposure to this substance can irritate the skin and eye (ATSDR (2001), EHC 71 (1987), MAK (DFG) vol.3 (1992)).
+(2) Acute toxicity data indicated that this substance was a moderate to severe eye irritant and a mild skin irritant (ACGIH (7th, 2014)).
+(3) In a skin irritation test with rabbits according to EPA OPPTS 870.2500, moderate irritation was seen after 72 hours (EPA Pesticides RED (2008)).
+(4) Skin disease or disorder of the respiratory tract/lung due to work involving exposure to this substance was described in Article 35 of the Ordinance for Enforcement of the Labor Standards Act (Notice No. 33, 1996).",,JP_CHRIP,1,Oc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.904G,J-GLOBAL,Oc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl,Train,1,2702,testing
+"EU_REACH:
+3-(dodecylsulfanyl)-1-[(1S,2R)-2,6,6-trimethylcyclohex-3-en-1-yl]butan-1-one",,878665-13-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16259/7/4/2/?documentUUID=f1db150b-c66e-4082-927b-024e1d791f32,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCSC(C)CC(=O)[C@@H]1[C@H](C=CCC1(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/101391704,PubChem,CCCCCCCCCCCCSC(C)CC(=O)[C@@H]1[C@@H](C)C=CCC1(C)C,Train,1,2702,testing
+"NZ_CCID:
+1-Naphthalenecarbonyl chloride",,879-18-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/66561D91-1E74-4479-A271-0A3EE95FB03A,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [CHEMWATCH]
+Eye Irritation
+R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C2C(=C1)C=CC=C2C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/70146,PubChem,O=C(Cl)c1cccc2ccccc12,Train,1,2702,testing
+"EU_REACH:
+2-ethoxy-N-hydroxybenzenecarboximidamide",,879-57-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20892/7/4/2/?documentUUID=dcdb399d-b9e9-49df-811b-1ac38197fba8,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=CC=CC=C1/C(=N/O)/N,https://pubchem.ncbi.nlm.nih.gov/compound/12052279,PubChem,CCOc1ccccc1/C(N)=N/O,Train,1,2702,testing
+"NZ_CCID:
+Chloroxylenol","NZ_CCID:
+p-Chloro-m-xylenol, 4-Chloro-3,5-dimethylphenol, 4-Chloro-3,5-xylenol",88-04-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7B451C7A-8E4A-4940-BCEC-7DE190E27B67,"NZ_CCID:
+Skin Irritation
+R-PHRASE: R 38 Irritating to skin. [N-CLASS]
+Eye Irritation
+SPECIES: Rabbit
+RESULT: Corneal opacity, severe irritation.
+REFERENCE SOURCE: [USEPA REDS]
+R-PHRASE: R 36 Irritating to the eyes. [N-CLASS]",,NZ_CCID,1,CC1=CC(=CC(=C1Cl)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/2723,PubChem,Cc1cc(O)cc(C)c1Cl,Train,1,2702,testing
+"JP_CHRIP:
+2,4,6-Trimethylaniline","JP_CHRIP:
+2,4,6-Trimethylaniline",88-05-1,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0023e.html,"JP_CHRIP:
+Based on a report of ""severe skin irritant"" as a human health effect (HSDB (2002)), the substance was classified into Category 2. As relevant information, the result in a standard Draize test with rabbits was ""moderate"" (RTECS (2006)).",,JP_CHRIP,1,Cc1cc(C)c(N)c(C)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.286B,J-GLOBAL,Cc1cc(C)c(N)c(C)c1,Train,1,2702,testing
+"JP_CHRIP:
+2,4,6-trichlorophenol
+
+NZ_CCID:
+2,4,6-Trichlorophenol
+
+US_HSDB:
+2,4,6-TRICHLOROPHENOL","JP_CHRIP:
+2,4,6-TCP
+Phenol, 2,4,6-trichloro-",88-06-2,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2028e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4A30E126-62C3-4C0F-880E-0E5512DB2FEF
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/4013","JP_CHRIP:
+[Rationale for the Classification]
+It was classified in Category 2 from (1), (2).
+
+[Evidence Data]
+(1) This substance is severely irritating to the eye, skin, and respiratory tract and causes erythema and pain in the eye and skin (Environmental Risk Assessment for Chemical Substances vol. 14 (Ministry of the Environment, 2016), GESTIS (Access on April 2020)).
+(2) This substance causes very slight irritation (EHC 93 (1989)).
+
+[Reference Data, etc.]
+(3) It was classified in Skin Irrit. 2 (H315) in EU-CLP classification (EU CLP classification (Access on June 2020)).
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,Oc1c(Cl)cc(Cl)cc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.543B,J-GLOBAL,Oc1c(Cl)cc(Cl)cc1Cl,Train,1,2702,testing
+"EU_CLP:
+diethylcarbamoyl chloride",,88-10-8,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCN(CC)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/6916,PubChem,CCN(CC)C(=O)Cl,Test,1,2702,testing
+"NZ_CCID:
+2-Furancarboxylic acid","NZ_CCID:
+2-furoic acid",88-14-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A5A6222E-F6B7-4758-986A-6911619A5572,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=COC(=C1)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/6919,PubChem,O=C(O)c1ccco1,Train,1,2702,testing
+"NZ_CCID:
+1-Chloro-2-(trifluoromethyl)-benzene","NZ_CCID:
+2-chlorobenzotrifluoride",88-16-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BAE12F84-0614-4DD3-9428-69DC7E6DC05E,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)C(F)(F)F)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/6921,PubChem,FC(F)(F)c1ccccc1Cl,Train,1,2702,testing
+"EU_REACH:
+2-(trifluoromethyl)aniline
+
+NZ_CCID:
+2-(Trifluoromethyl) aniline","NZ_CCID:
+2-aminobenzotrifluoride",88-17-5,Cat 2,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11316/7/4/2/?documentUUID=442e492d-4e78-411a-b8ae-d7db4bb9db91
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/74759AA1-0DD1-432D-8C7B-EE9B50DA325C","EU_REACH:
+Experimental study (OECD TG 404, GLP)
+
+NZ_CCID:
+Skin Irritation
+R-PHRASE: R 36/ 38. [Company data]
+Eye Irritation
+R-PHRASE: R 36/ 38. [Company data]",Provided,"EU_REACH, NZ_CCID",2,C1=CC=C(C(=C1)C(F)(F)F)N,https://pubchem.ncbi.nlm.nih.gov/compound/6922,PubChem,Nc1ccccc1C(F)(F)F,Train,1,2702,testing
+"EU_REACH:
+2-tert-butylphenol
+
+JP_CHRIP:
+2-tert-Butylphenol
+
+NZ_CCID:
+2-t-Butylphenol","JP_CHRIP:
+2-(1,1-Dimethylethyl)phenol
+2-tert-Butyl-1-hydroxybenzene
+o-tert-Butylphenol
+Phenol, 2-(1,1-dimethylethyl)-
+
+NZ_CCID:
+o-tert-butylphenol",88-18-6,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14446/7/4/2/?documentUUID=46d5c676-3066-419a-bc97-3dfae0db7624
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0058e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/422E8A3A-44DF-4CCC-BCD8-C221F1E45A09","EU_REACH:
+Experimental study (OECD TG 404, GLP)
+
+JP_CHRIP:
+In a skin irritation test by a 4-hour semi-occlusive application of 0.5 mL of the undiluted test substance to six rabbits (OECD TG404; GLP-compliant), all animals showed necrosis at 1-7 days after the application, and the primary skin irritation index was 5.67 (ECETOC TR66 (1995)). Therefore, it was classified in Category 1. Besides, it is described that this substance is strongly irritating or caustic to the skin and eyes (BUA 231 (2001)).
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,CC(C)(C)c1ccccc1O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J44.174K,J-GLOBAL,CC(C)(C)c1ccccc1O,Train,1,2702,testing
+"EU_REACH:
+[(5-chloroquinolin-8-yl)oxy]acetic acid",,88349-88-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19352/7/4/2/?documentUUID=7da56792-d23b-471f-94cb-45c1bbd9578a,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=C(C=CC(=C2N=C1)OCC(=O)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/15257197,PubChem,O=C(O)COc1ccc(Cl)c2cccnc12,Train,1,2702,testing
+"JP_CHRIP:
+2-tert-Butyl-5-methylphenol","JP_CHRIP:
+6-tert-butyl-m-cresol
+6-tert-Butyl-m-cresol; 2-tert-Butyl-5-methylphenol",88-60-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-meti-0055e.html,"JP_CHRIP:
+There are descriptions, ""The primary dermal stimulation score was from 5.44 to severe skin irritation"" (GLP)in the Draize test where this substance was administered to rabbits for 4 hours, ""moderate erythema , severe edema or hardening of the skin were observed until 2weeks after the admiration"" and it is concluded in SIDS to be ""corrosive against the skin"", it was classified in Category 1.",,JP_CHRIP,1,Cc1ccc(c(O)c1)C(C)(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J101.497H,J-GLOBAL,Cc1ccc(C(C)(C)C)c(O)c1,Train,1,2702,testing
+"EU_REACH:
+(6E)-cyclohexadec-6-en-1-one; (7Z)-cyclohexadec-7-en-1-one; (8E)-cyclohexadec-8-en-1-one; (8Z)-cyclohexadec-8-en-1-one",,88642-03-9,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/28335/7/4/2/?documentUUID=286be6e1-ada7-44e6-b0a2-94d06a83ab54,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CCCCCCC=CC(=O)CCCCCC1,https://pubchem.ncbi.nlm.nih.gov/compound/53750858,PubChem,O=C1C=CCCCCCCCCCCCCC1,Train,1,2702,testing
+"EU_REACH:
+2-(4-chlorophenyl)-2-[(1H-1,2,4-triazol-1-yl)methyl]hexanenitrile
+
+JP_CHRIP:
+myclobutanil; 2-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)hexanenitrile","JP_CHRIP:
+Myclobutanil",88671-89-0,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33152/7/4/2/?documentUUID=7165c20a-0a74-4596-809d-71c173060645
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0300e.html","EU_REACH:
+Experimental study (OECD TG 404, GLP)
+
+JP_CHRIP:
+Based on the report that the substance was found to be not irritating in rabbit tests (JMPR (1992)).",Provided,"EU_REACH, JP_CHRIP",2,CCCCC(Cn1cncn1)(C#N)c1ccc(Cl)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J343.426E,J-GLOBAL,CCCCC(C#N)(Cn1cncn1)c1ccc(Cl)cc1,Train,1,2702,testing
+"JP_CHRIP:
+2-Nitrotoluene","JP_CHRIP:
+1-Methyl-2-nitrobenzene
+Benzene, 1-methyl-2-nitro-
+o-Methylnitrobenzene
+o-Mononitrotoluene
+o-Nitrotoluene
+ONT",88-72-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2010e.html,"JP_CHRIP:
+[Rationale for the Classification]
+It was classified as ""Not classified"" from (1) - (4).
+
+[Evidence Data]
+(1) This substance was not irritating to the rabbit skin (Risk Assessment Report (Ministry of Health, Labour and Welfare, 2009)).
+(2) It was reported to be not irritating in a skin irritation test by 4-hour semi-occlusive application of this substance (purity 99.2%, 0.5 mL) to rabbits. Other than this, it was reported to be not irritating in three skin irritation tests by 24-hour application to the rabbit skin (EURAR (2008), AICIS IMAP (Access on April 2020)).
+(3) This substance is not irritating to the skin and eye (MAK (DFG) vol.8 (1997), SIAP (1994), GESTIS (Access on April 2020)).
+(4) There was no irritation in a skin irritation test with rabbits (24-hour occlusive application) similar to OECD TG 404 (REACH registration dossier (Access on May 2020))
+
+[Reference Data, etc.]
+(5) This substance irritates the skin, eye, and respiratory tract (HSDB (Access on April 2020)).",Provided,JP_CHRIP,1,Cc1ccccc1[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.906C,J-GLOBAL,Cc1ccccc1[N+](=O)[O-],Train,1,2702,testing
+"EU_CLP:
+ethyl 3-hydroxy-5-oxo-3-cyclohexene-1-carboxylate",,88805-65-6,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCOC(=O)C1CC(=CC(=O)C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/10559379,PubChem,CCOC(=O)C1CC(=O)C=C(O)C1,Test,1,2702,testing
+"JP_CHRIP:
+2-(1-Methylpropyl)-4,6-dinitrophenol","JP_CHRIP:
+2,4-Dinitro-6-(1-methylpropyl)phenol
+2,4-Dinitro-6-sec-butylphenol
+2-(1-Methylpropyl)-4,6-dinitrophenol
+4,6-Dinitro-2-sec-butylphenol
+Dinoseb
+Phenol, 2-(1-methylpropyl)-4,6-dinitro-",88-85-7,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0314e.html,"JP_CHRIP:
+Based on the description of the human health effects (CERI Hazard Data 2001-15 (2002)): ""Corrosive to the skin."" Although classified into Category 1A-1C, the substance should be placed in Category 1A from the viewpoint of safety if further subclassification is needed.",,JP_CHRIP,1,CCC(C)c1cc(cc(c1O)[N+](=O)[O-])[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.909H,J-GLOBAL,CCC(C)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1O,Train,1,2702,testing
+"NZ_CCID:
+Phthaloyl dichloride","NZ_CCID:
+phthaloyl chloride",88-95-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F4767F61-37AA-4D16-9069-FB0F79981745,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)C(=O)Cl)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/6955,PubChem,O=C(Cl)c1ccccc1C(=O)Cl,Train,1,2702,testing
+"NZ_CCID:
+Phthalic acid",,88-99-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C67E4C10-9670-479F-B09A-A901F9DDB4FD,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [CHEMWATCH]
+Eye Irritation
+R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,C1=CC=C(C(=C1)C(=O)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/1017,PubChem,O=C(O)c1ccccc1C(=O)O,Train,1,2702,testing
+"NZ_CCID:
+2,3-Pyridinedicarboxylic acid",,89-00-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F3BDD2F4-6835-42F9-9BDF-3857F48F6B3B,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(N=C1)C(=O)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/1066,PubChem,O=C(O)c1cccnc1C(=O)O,Train,1,2702,testing
+"EU_REACH:
+2-amino-5-cyano-N,3-dimethylbenzamide",,890707-29-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26859/7/4/2/?documentUUID=db07a0d4-2cd5-48e0-b352-5d6a2c92f104,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=CC(=C1N)C(=O)NC)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/25157282,PubChem,CNC(=O)c1cc(C#N)cc(C)c1N,Train,1,2702,testing
+"EU_REACH:
+ethyl 5-oxo-1-phenyl-4,5-dihydro-1H-pyrazole-3-carboxylate",,89-33-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6994/7/4/2/?documentUUID=fc6d4eca-2587-4e9a-bc52-566477b76487,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1=NN(C(=O)C1)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/66636,PubChem,CCOC(=O)C1=NN(c2ccccc2)C(=O)C1,Train,1,2702,testing
+"EU_REACH:
+phenyl N-(4,6-dimethoxypyrimidin-2-yl)carbamate",,89392-03-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7766/7/4/2/?documentUUID=803c9759-7b81-44e3-bf4d-2abb6e1ed07c,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC(=NC(=N1)NC(=O)OC2=CC=CC=C2)OC,https://pubchem.ncbi.nlm.nih.gov/compound/10945667,PubChem,COc1cc(OC)nc(NC(=O)Oc2ccccc2)n1,Train,1,2702,testing
+"EU_REACH:
+1,4-dimethoxy-2-nitrobenzene",,89-39-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5700/7/4/2/?documentUUID=ea9d5940-c2a3-4601-aa69-163a0b2a971f,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC(=C(C=C1)OC)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/66639,PubChem,COc1ccc(OC)c([N+](=O)[O-])c1,Train,1,2702,testing
+"EU_REACH:
+4-methoxy-3-nitrobenzoic acid",,89-41-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7180/7/4/2/?documentUUID=847f2149-976e-4370-9f96-a4ab4858a8df,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=C(C=C(C=C1)C(=O)O)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/66640,PubChem,COc1ccc(C(=O)O)cc1[N+](=O)[O-],Train,1,2702,testing
+"JP_CHRIP:
+4-Chloro-2-nitroaniline","JP_CHRIP:
+4-Chloro-2-nitroaniline
+Benzenamine, 4-chloro-2-nitro-",89-63-4,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2024e.html,"JP_CHRIP:
+There is a report that it was not irritating in a skin irritation test with rabbits (BUA 235 (2002)), but for humans, there are reports that it caused moderate to severe erythema (redness) and moderate edema (HSDB (Access on June 2017)). From the above, it was classified in Category 2. The classification was reviewed based on the information obtained in this survey.",,JP_CHRIP,1,Nc1ccc(Cl)cc1[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.549A,J-GLOBAL,Nc1ccc(Cl)cc1[N+](=O)[O-],Train,1,2702,testing
+"JP_CHRIP:
+o-sec-Butylphenol","JP_CHRIP:
+2-(1-Methylpropyl)phenol
+o-sec-Butylphenol
+Phenol, 2-(1-methylpropyl)-",89-72-5,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2027e.html,"JP_CHRIP:
+In a skin irritation test (OECD TG 404) with rabbits, by application of 0.5 mL of the undiluted liquid of this substance for 3 minutes, moderate to severe edema was observed 1 hour after administration and slight edema was observed 7 days after administration, therefore, it is judged that it was a corrosive substance (SIDS (2013)). In addition, there is a report that it was corrosive in another test with rabbits (SIDS (2013)). Moreover, there is a report that skin burns occurred in occupational exposures (ACGIH (7th, 2001)). From the above, it was classified in Category 1. Besides, in the animal tests, since there were no descriptions on details such as the scores, sub-categorization was not conducted.",Provided,JP_CHRIP,1,CCC(C)c1ccccc1O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.214J,J-GLOBAL,CCC(C)c1ccccc1O,Train,1,2702,testing
+"EU_REACH:
+2,4-dichlorobenzoyl chloride
+
+NZ_CCID:
+2,4-Dichlorobenzoyl chloride",,89-75-8,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5926/7/4/2/?documentUUID=e85f5100-49c4-4e3c-827c-b39d85d762ca
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B07D0A57-89F5-4053-B32E-1C1DB870F195","EU_REACH:
+Experimental study (OECD TG 404, GLP)
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",Provided,"EU_REACH, NZ_CCID",2,C1=CC(=C(C=C1Cl)Cl)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/66645,PubChem,O=C(Cl)c1ccc(Cl)cc1Cl,Train,1,2702,testing
+"EU_REACH:
+methyl 4-(isocyanatosulfonyl)-5-methylthiophene-3-carboxylate",,897671-34-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13349/7/4/2/?documentUUID=b58dd102-91e7-4d8c-8fd1-a67fffaba4b7,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(=CS1)C(=O)OC)S(=O)(=O)N=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/57957831,PubChem,COC(=O)c1csc(C)c1S(=O)(=O)N=C=O,Train,1,2702,testing
+"AU_HCIS:
+Cyclohexanone, 5-methyl-2-(1-methylethyl)-, (2R,5S)-rel-",,89-80-5,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6472,,,AU_HCIS,1,C[C@H]1CC[C@@H](C(=O)C1)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/443159,PubChem,CC(C)[C@H]1CC[C@H](C)CC1=O,Train,1,2702,testing
+"JP_CHRIP:
+thymol
+
+NZ_CCID:
+Thymol
+
+US_HSDB:
+THYMOL","NZ_CCID:
+Phenol, 5-methyl-2-(1-methylethyl)-, 5-Methyl-2-(1-methylethyl)phenol, Thyme camphor",89-83-8,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0143e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2B13D7AD-D9FD-4B91-8F17-E6BACE52A8EA
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/866","JP_CHRIP:
+Since it is documented that in a rabbit test (OECD TG 404), the substance was corrosive (IUCLID (2000)), and it is rated C; R34 in the EU classification, the substance was classified into Category 1.
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [EINECS]
+Eye Irritation
+R PHRASE: R 34 [EINECS]",Provided,"JP_CHRIP, NZ_CCID, US_HSDB",3,CC(C)c1ccc(C)cc1O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J10.606B,J-GLOBAL,Cc1ccc(C(C)C)c(O)c1,Train,1,2702,testing
+"EU_REACH:
+2,4-dihydroxybenzoic acid",,89-86-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20707/7/4/2/?documentUUID=5f072028-8ca1-4e6e-940a-9aea4e2bc414,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C=C1O)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/1491,PubChem,O=C(O)c1ccc(O)cc1O,Train,1,2702,testing
+"EU_REACH:
+2,4-dimethyl-1-nitrobenzene",,89-87-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12516/7/4/2/?documentUUID=23d6e709-dc4b-49ab-a335-9e026a067948,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)[N+](=O)[O-])C,https://pubchem.ncbi.nlm.nih.gov/compound/6991,PubChem,Cc1ccc([N+](=O)[O-])c(C)c1,Train,1,2702,testing
+"NZ_CCID:
+2-Chlorobenzylamine",,89-97-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CF8B6D5C-1928-42FF-BDA2-BFA1CDA2B56C,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)CN)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/66648,PubChem,NCc1ccccc1Cl,Train,1,2702,testing
+"EU_REACH:
+2-hydroxybenzaldehyde",,90-02-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5715/7/4/2/?documentUUID=574b7695-9ddc-4762-bb66-59747059d3bc,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C(=C1)C=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/6998,PubChem,O=Cc1ccccc1O,Train,1,2702,testing
+"JP_CHRIP:
+o-Anisidine","JP_CHRIP:
+o-Methoxyaniline
+1-Amino-2-methoxybenzene
+2-methoxyaniline [synonym:o-anisidine]
+Benzenamine, 2-methoxy-
+o-Anisidine
+ortho-Anisidine",90-04-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2080e.html,"JP_CHRIP:
+[Rationale for the Classification]
+It was classified as ""Not classified"" from (1).
+
+[Evidence Data]
+(1) It is reported that in a skin irritation test with rabbits (OECD TG404, GLP-compliant, n = 3), after 4-hour semi-occlusive application of undiluted this substance, erythema scores: 1 (2/3) and 0.7 (1/3) and a edema score: 0 were obtained after 72 hours, and animals fully recovered within 72 hours (DFGOT Vol.10 (1998), EU-RAR (2002), NICNAS IMAP (Accessed Dec. 2018), REACH registration dossier (Accessed Dec. 2018)).
+
+[Reference Data, etc.]
+(2) It is reported that in a skin irritation test with rabbits (n = 5), after 5-day open application of undiluted this substance, no irritation effects were seen after five days (REACH registration dossier (Accessed Dec. 2018)).",Provided,JP_CHRIP,1,COc1ccccc1N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.551C,J-GLOBAL,COc1ccccc1N,Train,1,2702,testing
+"EU_REACH:
+Chymotrypsin
+
+NZ_CCID:
+Chymotrypsin",,9004-07-3,Cat 2,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24772/7/4/2/?documentUUID=56c5276f-4b23-49a6-97ba-28ddb74700de
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3F47AA1C-0788-4FC0-9F16-2FE8E412062C","EU_REACH:
+Experimental study (OECD TG 404, GLP)
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",Provided,"EU_REACH, NZ_CCID",2,C1=CC=C(C=C1)CC(C(=O)NC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)CNC(=O)CNC(=O)CCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/4052643,PubChem,O=C(O)CCC(=O)NCC(=O)NCC(=O)NC(Cc1ccccc1)C(=O)Nc1ccc([N+](=O)[O-])cc1,Train,1,2702,testing
+"AU_HCIS:
+Poly(oxy-1,2-ethanediyl), .alpha.-(9Z)-9-octadecen-1-yl-.omega.-hydroxy-",,9004-98-2,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6501,,,AU_HCIS,1,CCCCCCCC\C=C/CCCCCCCCOCCO,https://cactus.nci.nih.gov/chemical/structure/9004-98-2/smiles,CACTUS,CCCCCCCC/C=C\CCCCCCCCOCCO,Train,1,2702,testing
+"EU_REACH:
+4'-Ethyl-3-fluorbiphenyl-4-boronic acid",,900796-46-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26610/7/4/2/?documentUUID=a751f1c8-aff8-42dd-bdad-cceb70723755,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,B(C1=C(C=C(C=C1)C2=CC=C(C=C2)CC)F)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/53402575,PubChem,CCc1ccc(-c2ccc(B(O)O)c(F)c2)cc1,Train,1,2702,testing
+"JP_CHRIP:
+1-Chloronaphthalene","JP_CHRIP:
+1-Chloro naphthalene
+alpha-Chloronaphthalene
+alpha-Naphthyl chloride",90-13-1,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0131e.html,"JP_CHRIP:
+Based on the description that it is an irritant to the skin (HSDB (Access on October 2016)), the substance was classified in Category 2.",,JP_CHRIP,1,Clc1cccc2ccccc12,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.553J,J-GLOBAL,Clc1cccc2ccccc12,Train,1,2702,testing
+"EU_CLP:
+1-naphtol",,90-15-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC=C2C(=C1)C=CC=C2O,https://pubchem.ncbi.nlm.nih.gov/compound/7005,PubChem,Oc1cccc2ccccc12,Test,1,2702,testing
+"EU_REACH:
+2-[(1E)-2-{3,3'-dichloro-4'-[(1E)-2-[2-oxo-1-(phenylcarbamoyl)propyl]diazen-1-yl]-[1,1'-biphenyl]-4-yl}diazen-1-yl]-3-oxo-N-phenylbutanamide; 2-[(1E)-2-{3,3'-dichloro-4'-[(1E)-2-{1-[(4-methoxyphenyl)carbamoyl]-2-oxopropyl}diazen-1-yl]-[1,1'-biphenyl]-4-yl}diazen-1-yl]-3-oxo-N-phenylbutanamide; 2-[(1E)-2-{3,3'-dichloro-4'-[(1E)-2-{1-[(4-methoxyphenyl)carbamoyl]-2-oxopropyl}diazen-1-yl]-[1,1'-biphenyl]-4-yl}diazen-1-yl]-N-(4-methoxyphenyl)-3-oxobutanamide",,90268-23-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10971/7/4/2/?documentUUID=cd922afa-38f6-4b83-a755-ac6ff2fb8869,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C(C(=O)NC1=CC=CC=C1)N=NC2=C(C=C(C=C2)C3=CC(=C(C=C3)N=NC(C(=O)C)C(=O)NC4=CC=C(C=C4)OC)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/91316050,PubChem,COc1ccc(NC(=O)C(N=Nc2ccc(-c3ccc(N=NC(C(C)=O)C(=O)Nc4ccccc4)c(Cl)c3)cc2Cl)C(C)=O)cc1,Train,1,2702,testing
+"EU_REACH:
+2-[(1E)-2-{3,3'-dichloro-4'-[(1E)-2-{1-[(2,4-dimethylphenyl)carbamoyl]-2-oxopropyl}diazen-1-yl]-[1,1'-biphenyl]-4-yl}diazen-1-yl]-N-(2,4-dimethylphenyl)-3-oxobutanamide; N-(4-chloro-2,5-dimethoxyphenyl)-2-[(1E)-2-{3,3'-dichloro-4'-[(1E)-2-{1-[(2,4-dimethylphenyl)carbamoyl]-2-oxopropyl}diazen-1-yl]-[1,1'-biphenyl]-4-yl}diazen-1-yl]-3-oxobutanamide; N-(4-chloro-2,5-dimethoxyphenyl)-2-[(1E)-2-{3,3'-dichloro-4'-[(1E)-2-{1-[(4-chloro-2,5-dimethoxyphenyl)carbamoyl]-2-oxopropyl}diazen-1-yl]-[1,1'-biphenyl]-4-yl}diazen-1-yl]-3-oxobutanamide",,90268-24-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2009/7/4/2/?documentUUID=040c07de-35ab-4655-a042-26dc7e7c7290,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)NC(=O)C(C(=O)C)N=NC2=C(C=C(C=C2)C3=CC(=C(C=C3)N=NC(C(=O)C)C(=O)NC4=CC(=C(C=C4OC)Cl)OC)Cl)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/44153097,PubChem,COc1cc(NC(=O)C(N=Nc2ccc(-c3ccc(N=NC(C(C)=O)C(=O)Nc4ccc(C)cc4C)c(Cl)c3)cc2Cl)C(C)=O)c(OC)cc1Cl,Train,1,2702,testing
+"JP_CHRIP:
+1-(N-Phenylamino)naphthalene","JP_CHRIP:
+N-(1-Naphthyl)aniline
+N-Phenyl-alpha-naphthylamine",90-30-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0060e.html,"JP_CHRIP:
+In a test with rabbits (US FDA standard), a slight positive reaction was observed in three out of six animals, and it was judged as a very slight irritant (CICAD 9 (1998)), and in another test with rabbits (OECD TG 404), slight erythema and edema were found in one out of three animals 1 hour after removal of the patch, but these disappeared after 24 or 72 hours, and it was judged to be not a skin irritant (CICAD 9 (1998)). Therefore, it was classified as ""Not classified.""",Provided,JP_CHRIP,1,N(c1ccccc1)c1cccc2ccccc12,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.913F,J-GLOBAL,c1ccc(Nc2cccc3ccccc23)cc1,Train,1,2702,testing
+"EU_CLP:
+2-phenylphenol (ISO); biphenyl-2-ol; 2-hydroxybiphenyl",,90-43-7,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC=C(C=C1)C2=CC=CC=C2O,https://pubchem.ncbi.nlm.nih.gov/compound/7017,PubChem,Oc1ccccc1-c1ccccc1,Test,1,2702,testing
+"NZ_CCID:
+9-Aminoacridine",,90-45-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D638D343-AC88-4699-9239-3AE1627A694C,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]",,NZ_CCID,1,C1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)N,https://pubchem.ncbi.nlm.nih.gov/compound/7019,PubChem,Nc1c2ccccc2nc2ccccc12,Train,1,2702,testing
+"NZ_CCID:
+Polyethylene glycol tridecyl ether phosphate","NZ_CCID:
+PEG-10 Tridecyl ether phosphate, PEG-3 Tridecyl ether phosphate, PEG-6 Tridecyl ether phosphate, Phosphoric acid, (ethoxylated tridecyl alcohol) esters, Poly(oxy-1,2-ethanediyl), .alpha.-tridecyl-.omega.-hydroxy-, phosphate, Poly(oxy-1,2-ethanediyl), alpha-tridecyl-omega-hydroxy-, phosphate, Polyethylene glycol 300 tridecyl ether phosphate, Polyethylene glycol 500 tridecyl ether phosphate, Polyoxyethylene (10) tridecyl ether phosphate, Polyoxyethylene (3) tridecyl ether phosphate, Polyoxyethylene (6) tridecyl ether phosphate, Trideceth-10 phosphate, Trideceth-3 phosphate, Trideceth-6 phosphate, Tridecyl alcohol, ethoxylated, phosphated",9046-01-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E12FB0D7-8C02-4E08-AFC3-21B9257DA8D0,"NZ_CCID:
+Skin Irritation
+R-PHRASE: R 35. [MSDS]
+Eye Irritation
+SPECIES:
+RESULT: Strong caustic effect.
+REFERENCE SOURCE: MSDS.",,NZ_CCID,1,CCCCCCCCCCCCCOCCOP(=O)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/20849296,PubChem,CCCCCCCCCCCCCOCCOP(=O)(O)O,Train,1,2702,testing
+"EU_REACH:
+12,12-bis[(2-hydroxypropoxy)methyl]-5,8,16,19-tetramethyl-4,7,10,14,17,20-hexaoxatricosane-2,22-diol; 12-[(2-hydroxypropoxy)methyl]-12-{[2-(2-hydroxypropoxy)propoxy]methyl}-5,8,16-trimethyl-4,7,10,14,17-pentaoxaicosane-2,19-diol; 9,9-bis({[2-(2-hydroxypropoxy)propoxy]methyl})-5,13-dimethyl-4,7,11,14-tetraoxaheptadecane-2,16-diol",,9051-49-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14284/7/4/2/?documentUUID=28bd8e44-3450-4289-8a15-5c9c3070c90b,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(CO)COCC(COCCCO)(COCCCO)COCCCO,https://pubchem.ncbi.nlm.nih.gov/compound/165768,PubChem,OCCCOCC(COCCCO)(COCCCO)COCCCO,Train,1,2702,testing
+"EU_CLP:
+2,4,6-tris(dimethylaminomethyl)phenol",,90-72-2,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CN(C)CC1=CC(=C(C(=C1)CN(C)C)O)CN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/7026,PubChem,CN(C)Cc1cc(CN(C)C)c(O)c(CN(C)C)c1,Test,1,2702,testing
+"EU_CLP:
+methyl 3-amino-2,2,3-trimethylbutyrate",,90886-53-6,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C)(C(=O)OC)C(C)(C)N,https://pubchem.ncbi.nlm.nih.gov/compound/154495,PubChem,COC(=O)C(C)(C)C(C)(C)N,Test,1,2702,testing
+"NZ_CCID:
+4,4'-Dimethoxybenzophenone",,90-96-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2259F14A-9157-4A8A-8EE2-8762D140F353,,,NZ_CCID,1,COC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)OC,https://pubchem.ncbi.nlm.nih.gov/compound/7032,PubChem,COc1ccc(C(=O)c2ccc(OC)cc2)cc1,Train,1,2702,testing
+"EU_REACH:
+(3-Fluor-4'-propyl[1,1'-biphenyl]-4-yl)-boric acid",,909709-42-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27737/7/4/2/?documentUUID=413fc396-9b0d-41d5-bb4c-9c6d517f8a01,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,B(C1=C(C=C(C=C1)C2=CC=C(C=C2)CCC)F)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/53402576,PubChem,CCCc1ccc(-c2ccc(B(O)O)c(F)c2)cc1,Train,1,2702,testing
+"EU_REACH:
+ethyl 2-({[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]amino}sulfonyl)benzoate",,90982-32-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23804/7/4/2/?documentUUID=88b55d42-7574-49aa-bd9a-369def13562a,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1=CC=CC=C1S(=O)(=O)NC(=O)NC2=NC(=CC(=N2)Cl)OC,https://pubchem.ncbi.nlm.nih.gov/compound/56160,PubChem,CCOC(=O)c1ccccc1S(=O)(=O)NC(=O)Nc1nc(Cl)cc(OC)n1,Train,1,2702,testing
+"NZ_CCID:
+Diphenylmethyl chloride","NZ_CCID:
+chlorodiphenylmethane",90-99-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/720E9977-DB7F-415D-8358-23F4DDED9B98,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)C(C2=CC=CC=C2)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7035,PubChem,ClC(c1ccccc1)c1ccccc1,Train,1,2702,testing
+"NZ_CCID:
+1,2-Bis(bromomethyl)-benzene","NZ_CCID:
+o-xylylene dibromide",91-13-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F9D5FE8C-3948-4353-8102-49445E13A56F,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C(=C1)CBr)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/66665,PubChem,BrCc1ccccc1CBr,Train,1,2702,testing
+"EU_REACH:
+1,2-dimethoxybenzene",,91-16-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11095/7/4/2/?documentUUID=3b616d4e-530b-4ad3-84a8-6967a57a0e74,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC=CC=C1OC,https://pubchem.ncbi.nlm.nih.gov/compound/7043,PubChem,COc1ccccc1OC,Train,1,2702,testing
+"AU_HCIS:
+quinoline
+
+JP_CHRIP:
+Quinoline
+
+KR_NCIS:
+Quinoline","JP_CHRIP:
+Quinoline
+1-Azonaphthalene
+1-Benzazene
+Benzo(b)pyridine
+
+KR_NCIS:
+1-Benzazene; 1-Benzazine; 1-Azanaphthalene; 1-Azonaphthalene; Benzopyridine",91-22-5,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3743
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2024e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP:
+[Rationale for the Classification]
+It was classified in Category 2 from (1) - (6).
+
+[Evidence Data]
+(1) The substance is irritating to the eye and skin and causes redness after skin contact and redness and pain after entry into the eye (Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013)).
+(2) In a skin irritation test (Draize test) in which this substance (100 mg) was applied to rabbits for 24 hours, moderate irritation was seen (AICIS IMAP (2015)).
+(3) In humans, the substance is irritating to the skin and severely irritating to the eyes, with the potential to cause permanent corneal damage and retinitis (AICIS IMAP (2015)).
+(4) Skin and eye exposure caused moderate to severe irritation in rabbits (Patty (6th, 2012)).
+(5) In a skin irritation test with rabbits, slight reddening became noticeable after 24 hours, and the skin irritation was mild (GESTIS (Access on April 2020)).
+(6) In a skin irritation test with rabbits according to CFR Title 16, section 1500.41, the mean score after 24/72 hours for erythema and edema was 0.9 and 1.5, respectively (REACH registration dossier (Access on June 2020)).
+
+[Reference Data, etc.]
+(7) It was classified in Skin Irrit. 2 (H315) in EU CLP classification (EU CLP classification (Access on July 2020)).",,"AU_HCIS, JP_CHRIP, KR_NCIS",3,c1ccc2ncccc2c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.922E,J-GLOBAL,c1ccc2ncccc2c1,Train,1,2702,testing
+"KR_NCIS:
+N,N-Bis(2-ethylhexyl)-[(1,2,4-triazol-1-yl)methyl] amine
+
+NZ_CCID:
+1H-1,2,4-Triazole-1-methanamine, N,N-bis(2-ethylhexyl)-","KR_NCIS:
+1-(N,N-bis(2-ethylhexyl)aminomethyl)-1,2,4-triazole; 1H-1,2,4-Triazole-1-methanamine, N,N-bis(2-ethylhexyl)-; 2-Ethyl-N-(2-ethylhexyl)-N-(1,2,4-triazol-1-ylmethyl)hexan-1-amine; Bis(2-ethylhexyl)(1H-1,2,4-triazol-1-ylmethyl)amine; N,N-Bis(2-ethylhexyl)-((1,2,4-triazol-1-yl)methyl)amine; N,N-Bis(2-ethylhexyl)-[(1,2,4-triazol-1-yl)methyl]amine; N,N-Bis(2-ethylhexyl)-1,2,4-triazol-1-ylmethanamine; N,N-Bis(2-ethylhexyl)-1H-[(1,2,4-triazol-1-yl)methyl]amine
+
+NZ_CCID:
+N,N-Bis(2-ethylhexyl)-((124-triazol-1-yl)methyl)amine",91273-04-0,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0963A0F7-04A0-4761-9CB0-E045AC83F50A","NZ_CCID:
+Skin Irritation
+R-PHRASE: R 34. [ECB]
+Eye Irritation
+R-PHRASE: R 34. [ECB]",,"KR_NCIS, NZ_CCID",2,CCCCC(CC)CN(CC(CC)CCCC)CN1C=NC=N1,https://pubchem.ncbi.nlm.nih.gov/compound/163595,PubChem,CCCCC(CC)CN(CC(CC)CCCC)Cn1cncn1,Train,1,2702,testing
+"EU_REACH:
+1-bromo-4-(trans-4-ethylcyclohexyl)benzene",,91538-82-8,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22818/7/4/2/?documentUUID=f45a9d05-7ab6-46d9-b380-71b8bd3b65ad,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1CCC(CC1)C2=CC=C(C=C2)Br,https://pubchem.ncbi.nlm.nih.gov/compound/13548369,PubChem,CCC1CCC(c2ccc(Br)cc2)CC1,Train,1,2702,testing
+"NZ_CCID:
+6-Methylquinoline",,91-62-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9A8FEC65-4613-441D-9EC4-5F1C326CE197,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=CC2=C(C=C1)N=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/7059,PubChem,Cc1ccc2ncccc2c1,Train,1,2702,testing
+"EU_REACH:
+2,2-bis(hydroxymethyl)propane-1,3-diol; 3-(prop-2-en-1-yloxy)prop-1-ene",,91648-24-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25548/7/4/2/?documentUUID=754a2c00-1ac8-4020-a214-dbe82a14d994,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CCOCC(CO)(CO)CO,https://pubchem.ncbi.nlm.nih.gov/compound/3086330,PubChem,C=CCOCC(CO)(CO)CO,Train,1,2702,testing
+"JP_CHRIP:
+N,N-Diethylaniline","JP_CHRIP:
+(Diethylamino)benzene
+Phenyldiethylamine",91-66-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0189e.html,"JP_CHRIP:
+Based on a result of ""slightly irritating"" in a rabbit test (OECD TG404) (IUCLID (2000)), the substance was classified as ""Not classified"".",Provided,JP_CHRIP,1,CCN(CC)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.559I,J-GLOBAL,CCN(CC)c1ccccc1,Train,1,2702,testing
+"KR_NCIS:
+Branched 2-nonylphenol","KR_NCIS:
+Phenol, 2-nonyl-, branched",91672-41-2,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCCC[C@H](CCC)CC1=CC=CC=C1O,https://pubchem.ncbi.nlm.nih.gov/compound/5748802,PubChem,CCCC[C@H](CCC)Cc1ccccc1O,Train,1,2702,testing
+"EU_REACH:
+[diamino(sulfanylidene)-λ⁵-phosphanyl](propyl)amine",,916809-14-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27049/7/4/2/?documentUUID=fb737627-2371-42c6-a48c-96b05b168be4,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCNP(=S)(N)N,https://pubchem.ncbi.nlm.nih.gov/compound/56623889,PubChem,CCCNP(N)(N)=S,Train,1,2702,testing
+"EU_REACH:
+Sorbitan, octanoate (2:3)",,91844-53-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11460/7/4/2/?documentUUID=37f98b1a-d7d7-4ba7-87fb-06820b918240,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCC(=O)OC([C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/87090353,PubChem,CCCCCCCC(=O)OC(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO,Train,1,2702,testing
+"EU_CLP:
+4,8,12-trimethyltrideca-3,7,11-trienoic acid, mixed isomers",,91853-67-7,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(=CCCC(=CCCC(=CCC(=O)O)C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/53791761,PubChem,CC(C)=CCCC(C)=CCCC(C)=CCC(=O)O,Test,1,2702,testing
+"JP_CHRIP:
+3-aminopropyltriethoxysilane
+
+NZ_CCID:
+3-(Triethoxysilyl) propylamine","JP_CHRIP:
+3-(triethoxysilyl)propylamine
+3-aminopropyltriethoxysilane
+
+NZ_CCID:
+3-aminopropyltriethoxysilane",919-30-2,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0056e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/23D4D724-8BF2-4AF3-853A-123015B1918E","JP_CHRIP:
+In the rabbits tests, alopecia, ulceration, and necrosis were observed. In addition, ecchymosis and moderate to severe edemas, though these symptoms were reversible, were observed (SIDS, accessed in July 2008). Since these observations indicate serious skin corrosion, the substance was classified into Category 1. Since no Draize score is available, refined classification within Category 1 is not available.
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CCO[Si](CCCN)(OCC)OCC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J14.168B,J-GLOBAL,CCO[Si](CCCN)(OCC)OCC,Train,1,2702,testing
+"EU_REACH:
+3,3'-dimethylbiphenyl-4,4'-diyl diisocyanate",,91-97-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10067/7/4/2/?documentUUID=1f10555c-f059-4e46-b842-43173d62f3cc,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=CC(=C1)C2=CC(=C(C=C2)N=C=O)C)N=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/7072,PubChem,Cc1cc(-c2ccc(N=C=O)c(C)c2)ccc1N=C=O,Train,1,2702,testing
+"NZ_CCID:
+1,1,3-Trichloroacetone",,921-03-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3BEDD587-C0DA-4CE6-8F9E-C9FE3AC5BCC1,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [CHEMWATCH]
+Eye Irritation
+R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C(C(=O)C(Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/13530,PubChem,O=C(CCl)C(Cl)Cl,Train,1,2702,testing
+"EU_REACH:
+N-(2-methoxyphenyl)-3-oxobutanamide",,92-15-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14534/7/4/2/?documentUUID=63a12323-4776-41b3-bef5-beeda1e92ece,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)CC(=O)NC1=CC=CC=C1OC,https://pubchem.ncbi.nlm.nih.gov/compound/7078,PubChem,COc1ccccc1NC(=O)CC(C)=O,Train,1,2702,testing
+"EU_REACH:
+Bis[2-(2-ethoxyethoxy)ethyl] cyclohexane-1,4-dicarboxylate",,922165-31-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6167/7/4/2/?documentUUID=d9258c40-4fb8-420e-9ab1-490dcad7407e,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOCCOCCOC(=O)C1CCC(CC1)C(=O)OCCOCCOCC,https://pubchem.ncbi.nlm.nih.gov/compound/25116113,PubChem,CCOCCOCCOC(=O)C1CCC(C(=O)OCCOCCOCC)CC1,Train,1,2702,testing
+"EU_REACH:
+4-trans-Pentyl-4'-trans-propyl-[1,1'-bicyclohexyl]",,92263-41-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27713/7/4/2/?documentUUID=bbc8510b-71a5-4dc1-a144-783658717c85,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCC1CCC(CC1)C2CCC(CC2)CCC,https://pubchem.ncbi.nlm.nih.gov/compound/21972079,PubChem,CCCCCC1CCC(C2CCC(CCC)CC2)CC1,Train,1,2702,testing
+"EU_REACH:
+methyl 3-methylbut-2-enoate",,924-50-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10290/7/4/2/?documentUUID=f2ba5bc9-2c4d-4dcf-938b-41c25c3a2c49,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=CC(=O)OC)C,https://pubchem.ncbi.nlm.nih.gov/compound/13546,PubChem,COC(=O)C=C(C)C,Train,1,2702,testing
+"EU_REACH:
+diisopropyl succinate",,924-88-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13751/7/4/2/?documentUUID=af7d3d87-f3b7-4929-8ad3-465f079f7f6a,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)OC(=O)CCC(=O)OC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/70213,PubChem,CC(C)OC(=O)CCC(=O)OC(C)C,Train,1,2702,testing
+"NZ_CCID:
+Phenylpiperazine","NZ_CCID:
+1-phenylpiperazine, N-Phenylpiperazine",92-54-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8697F25C-3221-4E41-A7A7-6537CFFF735B,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CN(CCN1)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/7096,PubChem,c1ccc(N2CCNCC2)cc1,Train,1,2702,testing
+"EU_REACH:
+2-methyl-4-phenylpentan-1-ol",,92585-24-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/9865/7/4/2/?documentUUID=f1a07cda-93e5-47b8-aaad-1db0ff4a14ee,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CC(C)C1=CC=CC=C1)CO,https://pubchem.ncbi.nlm.nih.gov/compound/3021997,PubChem,CC(CO)CC(C)c1ccccc1,Train,1,2702,testing
+"EU_REACH:
+dimethyl(propyl)amine",,926-63-6,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5294/7/4/2/?documentUUID=7eebb80b-ba61-4907-a61b-8ca3db60d0bd,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCN(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/61236,PubChem,CCCN(C)C,Train,1,2702,testing
+"EU_REACH:
+tert-butyl 2,2-dimethylpropaneperoxoate",,927-07-1,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14312/7/4/2/?documentUUID=34f4a364-67e4-4aa1-aea1-8d6d8fccae05,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C(=O)OOC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/61238,PubChem,CC(C)(C)OOC(=O)C(C)(C)C,Test,1,2702,testing
+"EU_REACH:
+3-methoxy-3,8,8,9,9-pentamethyl-2-oxa-7-thia-3,8-disiladecane",,927395-20-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13652/7/4/2/?documentUUID=84464ba3-ab5f-4779-8cc4-e66f624bb933,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)[Si](C)(C)SCCC[Si](C)(OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/87161845,PubChem,CO[Si](C)(CCCS[Si](C)(C)C(C)(C)C)OC,Test,1,2702,testing
+"JP_CHRIP:
+Phenothiazine","JP_CHRIP:
+10H-Phenothiazine
+Thiodiphenylamine",92-84-2,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2044e.html,"JP_CHRIP:
+Since there is a report that employees with skin irritation characterized by itching and reddening, developed a tolerance within a 1 to 4-week period following initial exposure (ACGIH (2001)), and the substance is classified as ""Skin irr"" by ACGIH, the substance was classified into Category 2. As relevant information, there are results of ""not irritating"" and ""slightly irritating"" in a rabbit and guinea pig test (IUCLID (2000)).",,JP_CHRIP,1,N1c2ccccc2Sc2ccccc12,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.932B,J-GLOBAL,c1ccc2c(c1)Nc1ccccc1S2,Train,1,2702,testing
+"NZ_CCID:
+3-Hexyne",,928-49-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F70BBCF0-3130-40C5-9716-6EBA9196C8DE,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCC#CCC,https://pubchem.ncbi.nlm.nih.gov/compound/13568,PubChem,CCC#CCC,Train,1,2702,testing
+"NZ_CCID:
+2-(2-Aminoethoxy) ethanol","NZ_CCID:
+diglycolamine",929-06-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A095839C-3161-4CAA-8FDF-26242B49A75B,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(COCCO)N,https://pubchem.ncbi.nlm.nih.gov/compound/13578,PubChem,NCCOCCO,Train,1,2702,testing
+"EU_CLP:
+4-[(3-hydroxypropyl)amino]-3-nitrophenol",,92952-81-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC(=C(C=C1O)[N+](=O)[O-])NCCCO,https://pubchem.ncbi.nlm.nih.gov/compound/5463795,PubChem,O=[N+]([O-])c1cc(O)ccc1NCCCO,Test,1,2702,testing
+"NZ_CCID:
+Triethylene glycol diamine",,929-59-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B4945A60-AAC8-4C2B-8EDF-9A96AD9D6D7D,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [CHEMWATCH]
+Eye Irritation
+R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C(COCCOCCN)N,https://pubchem.ncbi.nlm.nih.gov/compound/70248,PubChem,NCCOCCOCCN,Train,1,2702,testing
+"NZ_CCID:
+4-Amino-N,N-diethylaniline","NZ_CCID:
+N,N-Diethyl-1,4-phenylenediamine",93-05-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D9646130-1F87-4B82-AF88-1D885B828532,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCN(CC)C1=CC=C(C=C1)N,https://pubchem.ncbi.nlm.nih.gov/compound/7120,PubChem,CCN(CC)c1ccc(N)cc1,Train,1,2702,testing
+"NZ_CCID:
+Quinaldic acid",,93-10-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/741A1B51-D769-4B4B-9DE1-55AD30EB03AF,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C2C(=C1)C=CC(=N2)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7124,PubChem,O=C(O)c1ccc2ccccc2n1,Train,1,2702,testing
+"NZ_CCID:
+2-Naphthalenesulphonyl chloride",,93-11-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4BD91437-1AF4-4D57-B1DF-BD98B679AED9,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC=C2C=C(C=CC2=C1)S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7125,PubChem,O=S(=O)(Cl)c1ccc2ccccc2c1,Train,1,2702,testing
+"EU_REACH:
+[(2-methoxyphenyl)amino]methanesulfonic acid",,93-13-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17353/7/4/2/?documentUUID=1980edaf-8b4e-49a4-a123-88bfde81d7fa,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=CC=CC=C1NCS(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7126,PubChem,COc1ccccc1NCS(=O)(=O)O,Train,1,2702,testing
+"NZ_CCID:
+2-Methylbenzoyl chloride","NZ_CCID:
+o-toluoyl chloride",933-88-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CDEA65B6-2284-461E-A98A-D1F6B56CB1FD,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC1=CC=CC=C1C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/70276,PubChem,Cc1ccccc1C(=O)Cl,Train,1,2702,testing
+"NZ_CCID:
+3-Methoxycatechol",,934-00-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C5D5FD02-5A95-4F13-AD8A-1D15D096780E,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,COC1=CC=CC(=C1O)O,https://pubchem.ncbi.nlm.nih.gov/compound/13622,PubChem,COc1cccc(O)c1O,Train,1,2702,testing
+"NZ_CCID:
+3,4-Dimethoxyphenylacetic acid","NZ_CCID:
+(3,4-dimethoxyphenyl)acetic acid",93-40-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E2924FFF-2337-4E8F-BF01-E8734F4A5862,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,COC1=C(C=C(C=C1)CC(=O)O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/7139,PubChem,COc1ccc(CC(=O)O)cc1OC,Train,1,2702,testing
+"NZ_CCID:
+2-Methoxy-4-methylphenol","NZ_CCID:
+creosol",93-51-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CD6EC29F-988E-4346-A551-CB5F39EEEBD0,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=CC(=C(C=C1)O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/7144,PubChem,COc1cc(C)ccc1O,Train,1,2702,testing
+"NZ_CCID:
+2-Phenylpropionaldehyde",,93-53-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6662E995-E14A-4EBB-BF92-C3195C612FAE,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CC(C=O)C1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/7146,PubChem,CC(C=O)c1ccccc1,Train,1,2702,testing
+"NZ_CCID:
+N-Methylformanilide",,93-61-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DC70A157-DB6F-4DC8-B75B-05C2A59EDFF3,"NZ_CCID:
+Skin Irritation
+R-PHRASE: R 38. [Company data]",,NZ_CCID,1,CN(C=O)C1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/66737,PubChem,CN(C=O)c1ccccc1,Train,1,2702,testing
+"EU_REACH:
+3-[3-(triethoxysilyl)propyl]dihydrofuran-2,5-dione",,93642-68-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17384/7/4/2/?documentUUID=f503e813-65fb-4a82-a429-b4e54214227d,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](CCCC1CC(=O)OC1=O)(OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/3022158,PubChem,CCO[Si](CCCC1CC(=O)OC1=O)(OCC)OCC,Test,1,2702,testing
+"NZ_CCID:
+Mecoprop
+
+US_HSDB:
+Mecoprop","NZ_CCID:
+MCPP",93-65-2,Cat 2,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6EA5541A-E01C-42F6-A2C8-D8F6BEB3BAE4
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1738","NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [IUCLID 2000]
+Eye Irritation
+R PHRASE: R 41 [IUCLID 2000]",,"NZ_CCID, US_HSDB",2,CC1=C(C=CC(=C1)Cl)OC(C)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7153,PubChem,Cc1cc(Cl)ccc1OC(C)C(=O)O,Train,1,2702,testing
+"EU_CLP:
+allidochlor (ISO); N,N-diallylchloroacetamide",,93-71-0,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C=CCN(CC=C)C(=O)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/7157,PubChem,C=CCN(CC=C)C(=O)CCl,Test,1,2702,testing
+"EU_CLP:
+fenoprop (ISO); 2-(2,4,5-trichlorophenoxy)propionic acid",,93-72-1,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C(=O)O)OC1=CC(=C(C=C1Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7158,PubChem,CC(Oc1cc(Cl)c(Cl)cc1Cl)C(=O)O,Test,1,2702,testing
+"JP_CHRIP:
+2,4,5-T
+
+KR_NCIS:
+2,4,5-T","JP_CHRIP:
+2,4,5-Trichlorophenoxyacetic acid
+Acetic acid, (2,4,5-trichlorophenoxy)-
+
+KR_NCIS:
+2,4,5-Trichlorophenoxyacetate",93-76-5,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0598e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP:
+It was classified as Category 2 from description that the skin is stimulated (ICSC (J) (1995), HSDB (2005), HSFS (2001), and SITTIG (4th, 2002)).",,"JP_CHRIP, KR_NCIS",2,OC(=O)COc1cc(Cl)c(Cl)cc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.941A,J-GLOBAL,O=C(O)COc1cc(Cl)c(Cl)cc1Cl,Train,1,2702,testing
+"EU_REACH:
+N,N'-Di-sec-butyl-1,1-dimethylsilanediamine",,93777-98-1,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23717/7/4/2/?documentUUID=b86d1fe8-11bb-4fa5-867b-aac89691f0be,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)N[Si](C)(C)NC(C)CC,https://pubchem.ncbi.nlm.nih.gov/compound/16205771,PubChem,CCC(C)N[Si](C)(C)NC(C)CC,Train,1,2702,testing
+"EU_REACH:
+2-decyltetradecanoic acid",,93778-52-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18880/7/4/2/?documentUUID=94996dc2-25f1-48c4-b645-62a8a330f8e1,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCCCC(CCCCCCCCCC)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/175556,PubChem,CCCCCCCCCCCCC(CCCCCCCCCC)C(=O)O,Train,1,2702,testing
+"EU_REACH:
+2-octyldodecyl 3-methylheptadecanoate",,93803-87-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10874/7/4/2/?documentUUID=0c50fc58-8a28-4be4-bd24-68800b7cbf22,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCCCC(CCCCCCCC)COC(=O)CCCCCCCCCCCCCCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/44147658,PubChem,CCCCCCCCCCC(CCCCCCCC)COC(=O)CCCCCCCCCCCCCCC(C)C,Train,1,2702,testing
+"EU_REACH:
+N-(4-carbamoylphenyl)-4-methoxy-3-nitrobenzamide",,93839-20-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5382/7/4/2/?documentUUID=1971445a-d177-43c4-804d-616fc1761b0f,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=C(C=C(C=C1)C(=O)NC2=CC=C(C=C2)C(=O)N)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/874576,PubChem,COc1ccc(C(=O)Nc2ccc(C(N)=O)cc2)cc1[N+](=O)[O-],Train,1,2702,testing
+"EU_REACH:
+N-(4-carbamoylphenyl)-4-nitrobenzamide",,93839-21-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5404/7/4/2/?documentUUID=7bccd3e7-2a40-4f41-9b75-a13115a6a96b,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1C(=O)N)NC(=O)C2=CC=C(C=C2)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/689161,PubChem,NC(=O)c1ccc(NC(=O)c2ccc([N+](=O)[O-])cc2)cc1,Train,1,2702,testing
+"EU_REACH:
+5-nitro-1,3-dihydro-2H-benzimidazol-2-one",,93-84-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1875/7/4/2/?documentUUID=f23e7883-f4ff-46eb-a073-90b6306043a5,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=C(C=C1[N+](=O)[O-])NC(=O)N2,https://pubchem.ncbi.nlm.nih.gov/compound/3725611,PubChem,O=c1[nH]c2ccc([N+](=O)[O-])cc2[nH]1,Train,1,2702,testing
+"EU_REACH:
+(2E)-3-methyl-5-phenylpent-2-enenitrile",,93893-89-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20910/7/4/2/?documentUUID=42fa25c8-63d2-4f0b-bcc0-1ec59b8d7559,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C/C(=C\C#N)/CCC1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/1585264,PubChem,C/C(=C\C#N)CCc1ccccc1,Train,1,2702,testing
+"EU_REACH:
+ethyl benzoylacetate",,94-02-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33015/7/4/2/?documentUUID=61b95e60-f5f3-4e33-b278-3027ce1f8ab0,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CC(=O)C1=CC=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/7170,PubChem,CCOC(=O)CC(=O)c1ccccc1,Train,1,2702,testing
+"NZ_CCID:
+Vinyl 2-ethylhexanoate","NZ_CCID:
+Hexanoic acid, 2-ethyl-, ethenyl ester",94-04-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/20BC4CA4-EB4E-4589-AF5A-D0A3343509DC,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [CHEMWATCH]
+Eye Irritation
+R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,CCCCC(CC)C(=O)OC=C,https://pubchem.ncbi.nlm.nih.gov/compound/62343,PubChem,C=COC(=O)C(CC)CCCC,Train,1,2702,testing
+"NZ_CCID:
+Ethyl ethoxymethylenecyanoacetate","NZ_CCID:
+2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester",94-05-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E2D3CA9C-29EF-48E7-B3BF-44C8EFAC8600,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [CHEMWATCH]
+Eye Irritation
+R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,CCO/C=C(\C#N)/C(=O)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/1715183,PubChem,CCO/C=C(\C#N)C(=O)OCC,Train,1,2702,testing
+"NZ_CCID:
+Di(trimethylolpropane) tetraacrylate",,94108-97-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A46DEE8A-C385-4F3D-A094-6E07311F1746,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [CHEMWATCH]
+Eye Irritation
+R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,CCC(COCC(CC)(COC(=O)C=C)COC(=O)C=C)(COC(=O)C=C)COC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/175585,PubChem,C=CC(=O)OCC(CC)(COCC(CC)(COC(=O)C=C)COC(=O)C=C)COC(=O)C=C,Train,1,2702,testing
+"JP_CHRIP:
+Propyl 4-hydroxybenzoate",,94-13-3,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0062e.html,"JP_CHRIP:
+[Rationale for the Classification]
+It was classified as ""Not classified"" from (1).
+
+[Evidence Data]
+(1) It is reported that in a skin irritation test with rabbits (n = 3) (equivalent to OECD TG 404, semi-occlusive, 4-hour application, 7-day observation), no erythema or edema was seen in any animal (erythema/eschar score: 0/0/0, edema score: 0/0/0) (REACH registration dossier (Accessed Oct. 2020)).",Provided,JP_CHRIP,1,CCCOC(=O)c1ccc(O)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.943H,J-GLOBAL,CCCOC(=O)c1ccc(O)cc1,Train,1,2702,testing
+"AU_HCIS:
+2H-Pyran, tetrahydro-4-methyl-2-phenyl-",,94201-73-7,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3724,,,AU_HCIS,1,CC1CCOC(C1)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/3024003,PubChem,CC1CCOC(c2ccccc2)C1,Train,1,2702,testing
+"EU_REACH:
+2-(2-{2-[(2-ethylhexanoyl)oxy]ethoxy}ethoxy)ethyl 2-ethylhexanoate",,94-28-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15760/7/4/2/?documentUUID=564ef9a7-74fa-4b6d-9d77-730550660c51,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)C(=O)OCCOCCOCCOC(=O)C(CC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/7185,PubChem,CCCCC(CC)C(=O)OCCOCCOCCOC(=O)C(CC)CCCC,Test,1,2702,testing
+"NZ_CCID:
+Thiobenzoylmercaptoacetic acid",,942-91-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8586B177-994C-412A-91F6-3B96924008AA,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)C(=S)SCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/70336,PubChem,O=C(O)CSC(=S)c1ccccc1,Train,1,2702,testing
+"EU_REACH:
+2-(4-chlorophenyl)-3-cyclopropyl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol",,94361-06-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32337/7/4/2/?documentUUID=75ec2bab-864c-4886-8b06-cb9c17b5cc50,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C1CC1)C(CN2C=NC=N2)(C3=CC=C(C=C3)Cl)O,https://pubchem.ncbi.nlm.nih.gov/compound/86132,PubChem,CC(C1CC1)C(O)(Cn1cncn1)c1ccc(Cl)cc1,Train,1,2702,testing
+"EU_REACH:
+(4-chloro-2-fluoro-3-methoxyphenyl)boronic acid",,944129-07-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8067/7/4/2/?documentUUID=a2372e9a-98b4-453d-bff5-65ca3f556598,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,B(C1=C(C(=C(C=C1)Cl)OC)F)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/44129706,PubChem,COc1c(Cl)ccc(B(O)O)c1F,Test,1,2702,testing
+"NZ_CCID:
+Benzyl nicotinate",,94-44-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CD221582-EB13-43C2-B10C-AD27BDB63AE6,,,NZ_CCID,1,C1=CC=C(C=C1)COC(=O)C2=CN=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/7191,PubChem,O=C(OCc1ccccc1)c1cccnc1,Train,1,2702,testing
+"EU_REACH:
+2-(benzoyloxy)ethyl benzoate",,94-49-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22707/7/4/2/?documentUUID=579d34e7-ad34-4624-8d1a-d3ebc1ab1110,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C(=O)OCCOC(=O)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/66750,PubChem,O=C(OCCOC(=O)c1ccccc1)c1ccccc1,Train,1,2702,testing
+"JP_CHRIP:
+Safrole
+
+US_HSDB:
+Safrole","JP_CHRIP:
+5-(2-Propenyl)-1,3-benzodioxole
+Safrole",94-59-7,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/07-mhlw-0053e.html
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/2653","JP_CHRIP:
+Since topical application of the substance on the skin of rabbits for 24 hours was moderately irritating (HSDB, 2005), the substance was classified into Category 2.",,"JP_CHRIP, US_HSDB",2,C=CCc1ccc2OCOc2c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.946B,J-GLOBAL,C=CCc1ccc2c(c1)OCO2,Train,1,2702,testing
+"JP_CHRIP:
+Dodecane-12-lactam","JP_CHRIP:
+12-dodecanelactam
+lauryl lactam",947-04-6,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-0017e.html,"JP_CHRIP:
+It was classified as ""Not classified"" because it was assessed to be not irritating in a 4-hour application test with rabbits (OECD TG 404) in SIDS (2005).",Provided,JP_CHRIP,1,O=C1CCCCCCCCCCCN1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J12.504K,J-GLOBAL,O=C1CCCCCCCCCCCN1,Train,1,2702,testing
+"EU_REACH:
+diphenylsilanediol",,947-42-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17717/7/4/2/?documentUUID=dc859229-062f-40f4-a70c-ec5f5a1d99ed,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)[Si](C2=CC=CC=C2)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/13693,PubChem,O[Si](O)(c1ccccc1)c1ccccc1,Train,1,2702,testing
+"EU_REACH:
+α,α'-propylenedinitrilodi-o-cresol",,94-91-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5314/7/4/2/?documentUUID=8552fa04-76b1-4821-a605-b8c8354e8115,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CN=CC1=CC=CC=C1O)N=CC2=CC=CC=C2O,https://pubchem.ncbi.nlm.nih.gov/compound/7210,PubChem,CC(CN=Cc1ccccc1O)N=Cc1ccccc1O,Train,1,2702,testing
+"EU_REACH:
+ethyl 3-{5-[(3-chloro-2-fluorophenyl)methyl]-2,4-dimethoxyphenyl}-3-oxopropanoate",,949465-81-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18428/7/4/2/?documentUUID=300c2e38-e1e7-4097-8bdd-0386a1a50164,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CC(=O)C1=C(C=C(C(=C1)CC2=C(C(=CC=C2)Cl)F)OC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/24809654,PubChem,CCOC(=O)CC(=O)c1cc(Cc2cccc(Cl)c2F)c(OC)cc1OC,Train,1,2702,testing
+"EU_REACH:
+ethyl 6-(3-chloro-2-fluorobenzyl)-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate",,949465-91-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18431/7/4/2/?documentUUID=20ee60e5-6446-4c3e-87a1-1f53967c609f,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1=CN(C2=C(C1=O)C=C(C(=C2)OC)CC3=C(C(=CC=C3)Cl)F)[C@H](CO)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/24803354,PubChem,CCOC(=O)c1cn([C@H](CO)C(C)C)c2cc(OC)c(Cc3cccc(Cl)c3F)cc2c1=O,Train,1,2702,testing
+"EU_REACH:
+2,4-dichloro-1-(chloromethyl)benzene",,94-99-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17874/7/4/2/?documentUUID=ad741764-0c14-4966-aa55-eb75df3d0ec1,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C(C=C1Cl)Cl)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/7212,PubChem,ClCc1ccc(Cl)cc1Cl,Train,1,2702,testing
+"JP_CHRIP:
+Sulfallate","JP_CHRIP:
+Sulfallate",95-06-7,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/07-mhlw-0054e.html,"JP_CHRIP:
+The substance is reported to be a moderate skin irritant to humans in a test in which the application period is not provided (NTP TR 115, 1978). Based on this report, the substance was classified into Category 2.",,JP_CHRIP,1,CCN(CC)C(=S)SCC(=C)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.707D,J-GLOBAL,C=C(Cl)CSC(=S)N(CC)CC,Train,1,2702,testing
+"NZ_CCID:
+2-Methylbenzoxazole",,95-21-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D2304796-9E2A-4633-9494-3845E1326220,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=NC2=CC=CC=C2O1,https://pubchem.ncbi.nlm.nih.gov/compound/7225,PubChem,Cc1nc2ccccc2o1,Train,1,2702,testing
+"EU_REACH:
+5-amino-1,3-dihydro-2H-benzimidazol-2-one",,95-23-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1949/7/4/2/?documentUUID=9caeb93f-64b0-424a-a6b3-f186fa26a87d,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=C(C=C1N)NC(=O)N2,https://pubchem.ncbi.nlm.nih.gov/compound/66765,PubChem,Nc1ccc2[nH]c(=O)[nH]c2c1,Train,1,2702,testing
+"NZ_CCID:
+1H-Imidazole-1-ethanol, 2-(8-heptadecenyl)-4,5-dihydro-",,95-38-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3ED1723E-58E9-4675-8AC9-EAE5A25FC92E,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [CHEMWATCH]
+Eye Irritation
+R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCCCCCCC/C=C/CCCCCCCC1=NCCN1CCO,https://pubchem.ncbi.nlm.nih.gov/compound/5367893,PubChem,CCCCCCCC/C=C/CCCCCCCC1=NCCN1CCO,Train,1,2702,testing
+"NZ_CCID:
+2-Bromotoluene",,95-46-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C27D84EC-1F3E-4097-AB78-E1873AB66937,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=CC=CC=C1Br,https://pubchem.ncbi.nlm.nih.gov/compound/7236,PubChem,Cc1ccccc1Br,Train,1,2702,testing
+"AU_HCIS:
+o-xylene
+
+JP_CHRIP:
+o-Xylene
+
+KR_NCIS:
+o-Xylene
+
+NZ_CCID:
+Benzene, 1,2-dimethyl-
+
+US_HSDB:
+2-XYLENE","AU_HCIS:
+Benzene, 1,2-dimethyl-
+
+JP_CHRIP:
+1,2-Dimethylbenzene
+Benzene, 1,2-dimethyl-
+o-Xylol
+ortho-Xylene
+Xylenes
+
+KR_NCIS:
+1,2-Dimethylbenzene; 1,2-Xylene; 2-Methyltoluene; Benzene, 1,2-dimethyl-; o-Dimethylbenzene; ortho-Xylene; XYLENE, ORTHO-
+
+NZ_CCID:
+1,2-Xylene, 2-Xylene, o-Dimethylbenzene, o-Methyltoluene, o-Xylene",95-47-6,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3354
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0103e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/44B1B819-9009-4E06-981D-AF840F1C87B0
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/134","JP_CHRIP:
+Based on the description in CERI Hazard Data 96-30 (i) (1997): Xylene mixtures (Cas 1330-20-7) cause moderate skin irritation, and the acute effects of o-xylene on human health are considered essentially equivalent to those of xylene mixtures. The substance is considered ""moderately irritating"" to the skin.
+
+NZ_CCID:
+Skin Irritation
+R-PHRASE: R 38 Irritaint to skin. [IUCLID 2000]{NCLASS]
+Eye Irritation
+SPECIES: Rabbit
+RESULT: Moderately irritating
+REFERENCE SOURCE: VEBA Oel AG Gelsenkirchen VEBA OEL AG D-45896 Gelsenkirchen (134)(134) Kennah, H.E. et al., Fundamental and Applied Toxicology 12, 258-268 (1989). [IUCLID 2000]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,Cc1ccccc1C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.563G,J-GLOBAL,Cc1ccccc1C,Train,1,2702,testing
+"AU_HCIS:
+o-cresol [1]
+
+JP_CHRIP:
+o-Cresol
+
+KR_NCIS:
+2-Methylphenol
+
+NZ_CCID:
+2-Cresol
+
+US_HSDB:
+o-CRESOL","AU_HCIS:
+o-cresol  [2]
+p-cresol  [3]
+mix-cresol [4]
+Phenol, 2-methyl-
+o-cresol
+p-cresol
+mix-cresol
+
+JP_CHRIP:
+2-Hydroxy-1-methylbenzene
+2-Methylphenol
+o-Cresol; 2-Methylphenol
+ortho-Hydroxytoluene
+Phenol, 2-methyl-
+
+KR_NCIS:
+1-Hydroxy-2-methylbenzene; 1-Methyl-2-hydroxybenzene; 2-Hydroxy-1-methylbenzene; CRESOL, ORTHO; o-Cresol; O-CRESYLIC ACID; o-Hydroxytoluene; ORTHO-CRESOL; Phenol, 2-methyl-
+
+NZ_CCID:
+o-Cresol",95-48-7,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1067
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2032e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F12DC57A-0908-4829-BA1D-A6C6510C1CBF
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1813","JP_CHRIP:
+There are several reports that severe irritation or corrosivity was observed in tests in which this substance was applied to the skin of rabbits (EHC 168 (1995), Initial Risk Assessment Report (NITE, CERI, NEDO, 2007), PATTY (6th, 2012)). In addition, there is a description that this substance showed corrosivity to the skin (SIDS (2001), Environmental Risk Assessment for Chemical Substances Vol. 5 (Ministry of the Environment, 2006)). From the above, it was classified in Category 1. Besides, this substance was classified in ""C; R34"" in EU DSD classification and in ""H314 Skin Corr. 1B"" in EU CLP classification.
+
+NZ_CCID:
+Skin Irritation
+R-PHRASE: R 34. [Company data]
+Eye Irritation
+R-PHRASE: R 34. [Company data]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,Cc1ccccc1O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.176B,J-GLOBAL,Cc1ccccc1O,Train,1,2702,testing
+"EU_REACH:
+1-chloro-2-methylbenzene
+
+JP_CHRIP:
+o-Chlorotoluene","JP_CHRIP:
+1-Chloro-2-methylbenzene
+2-chlorotoluene
+Benzene, 1-chloro-2-methyl-
+o-Tolyl chloride",95-49-8,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13832/7/4/2/?documentUUID=d79909c7-c95a-459e-a44a-0594f258f5c8
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2026e.html","EU_REACH:
+Experimental study (OECD TG 404, GLP)
+
+JP_CHRIP:
+There is a report that in a skin irritation test (OECD TG 404) with rabbits, erythema was observed after 4-hour application but disappeared later (SIDS (2004), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). Besides, in multiple tests in which this substance was applied for 24 hours, although moderate edema, severe erythema and necrosis, etc. were observed, and moderate desquamation, thickening at the application site, exfoliation and scarring were observed 1 week after administration (SIDS (2004), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), it was judged to be mild irritation in the OECD-compliant test, therefore, it was classified as ""Not classified"" (Category 3 in UN GHS classification). The category was changed according to the revised guideline.",Provided,"EU_REACH, JP_CHRIP",2,Cc1ccccc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.564E,J-GLOBAL,Cc1ccccc1Cl,Train,1,2702,testing
+"JP_CHRIP:
+o-Dichlorobenzene
+
+KR_NCIS:
+1,2-Dichlorobenzene","JP_CHRIP:
+1,2-Dichlorobenzene
+ortho-Dichlorobenzene
+
+KR_NCIS:
+o-Dichlorobenzene",95-50-1,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0080e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP:
+There is a report that in a skin irritation test with rabbits, slight to moderate erythema and edema were observed 72 hours after 4-hour application of 0.5 mL of an undiluted solution of this substance (SIDS (2004), Hazard Assessment Report (CERI, NITE, 2008)). It is also reported that edema and blisters were observed as a result of application of this substance in humans (SIDS (2004), DFGOT vol.1 (1990)). From the above, this substance was classified in Category 2. Besides, this substance was classified as ""Skin Irrit. 2 H315"" in the EU CLP classification (ECHA CL Inventory (Access on September 2015)).",,"JP_CHRIP, KR_NCIS",2,Clc1ccccc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.951I,J-GLOBAL,Clc1ccccc1Cl,Train,1,2702,testing
+"JP_CHRIP:
+o-Chloroaniline","JP_CHRIP:
+1-Amino-2-chlorobenzene
+2-Chloroaminobenzene
+Benzenamine, 2-chloro-
+Fast yellow GC base",95-51-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-meti-0005e.html,"JP_CHRIP:
+In a skin irritation test using rabbits (OECD TG 404), there is a report that application of 0.1 mL of this substance resulted in no irritation (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), BUA 57 (1991)). Therefore, it was classified as ""Not classified.""",Provided,JP_CHRIP,1,Nc1ccccc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.952G,J-GLOBAL,Nc1ccccc1Cl,Train,1,2702,testing
+"EU_REACH:
+benzene-1,2-diamine
+
+JP_CHRIP:
+o-Phenylenediamine","JP_CHRIP:
+o-Phenylenediamine
+1,2-Benzenediamine
+1,2-Phenylenediamine
+2-Aminoaniline
+o-Diaminobenzene",95-54-5,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2001/7/4/2/?documentUUID=2817d238-3fe2-4752-a730-e9161ac1f037
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2008e.html","EU_REACH:
+Experimental study (OECD TG 404, GLP)
+
+JP_CHRIP:
+[Rationale for the Classification]
+Based on (1) and (2), it was classified as ""Not classified.""
+
+[Evidence Data]
+(1) In a skin irritation test with rabbits according to OECD TG 404, it is reported to show no irritation (DFGOT vol.13 (1999)).
+(2) It is reported that in a skin irritation test with 3 rabbits according to OECD TG 404, very light erythema was observed after 48 hours. This was reversible after 72 hours, and that the mean scores at 24/48/72 hours for erythema and edema were 0.6 and 0, respectively (REACH registration dossier (Access on June 2019)).",Provided,"EU_REACH, JP_CHRIP",2,Nc1ccccc1N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.954C,J-GLOBAL,Nc1ccccc1N,Train,1,2702,testing
+"JP_CHRIP:
+2-Chlorophenol","JP_CHRIP:
+2-Chloro-1-hydroxybenzene
+2-Hydroxychlorobenzene
+2-Monochlorophenol
+o-Chlorophenol
+Phenol, 2-chloro-",95-57-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-meti-0008e.html,"JP_CHRIP:
+For animals, ""corrosion with severe skin damages such as erythema, dropsy, discoloration, etc.""(ATSDR (1999)) has been described in the direct dosage study to skin of rabbits. For humans, ""concern about occurrence of contact dermatitis"" (HSDB (2005)) has been described. Therefore, it was classified into Category 1.",,JP_CHRIP,1,Oc1ccccc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.566A,J-GLOBAL,Oc1ccccc1Cl,Train,1,2702,testing
+"JP_CHRIP:
+1,2,4-Trimethylbenzene","JP_CHRIP:
+Benzene, 1,2,4-trimethyl-
+Pseudocumene",95-63-6,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2036.html,"JP_CHRIP:
+【分類根拠】
+（１）、（２）より、区分2とした。なお、新たな知見に基づき、分類結果を変更した。
+
+【根拠データ】
+（１）本物質は眼、皮膚、気道を刺激し、中枢神経系に影響を与えることがあり、液体を飲み込むと肺に吸い込んで化学性肺炎を起こすことがある。吸入や経口摂取すると錯乱や咳、眩暈、嗜眠、頭痛、咽頭痛、嘔吐を生じ、皮膚に付くと発赤や皮膚の乾燥、眼に入ると発赤や痛みを生じる（MOE 初期評価 (2009)）。
+（２）EU CLPではSkin Irrit. 2に分類されている。",,JP_CHRIP,1,Cc1ccc(C)c(C)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.567J,J-GLOBAL,Cc1ccc(C)c(C)c1,Train,1,2702,testing
+"AU_HCIS:
+Benzenamine, 3,4-dimethyl-",,95-64-7,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5306,,,AU_HCIS,1,CC1=C(C=C(C=C1)N)C,https://pubchem.ncbi.nlm.nih.gov/compound/7248,PubChem,Cc1ccc(N)cc1C,Train,1,2702,testing
+"JP_CHRIP:
+3,4-xylenol; 3,4-Dimethylphenol
+
+KR_NCIS:
+3,4-Dimethylphenol
+
+NZ_CCID:
+3,4-Dimethylphenol","JP_CHRIP:
+3,4-Xylenol
+Phenol, 3,4-dimethyl-
+
+KR_NCIS:
+1,3,4-Xylenol; 1-Hydroxy-3,4-dimethylbenzene; 3,4-Xylenol; 4,5-Dimethylphenol; 4-Hydroxy-1,2-dimethylbenzene; 4-Hydroxy-o-xylene
+
+NZ_CCID:
+3,4-xylenol",95-65-8,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2026e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AFACE293-BD6D-498E-83E8-A9E95710D76E","JP_CHRIP:
+[Rationale for the Classification]
+Based on (1), it was classified in Category 1. Besides, since new data was obtained, the category was changed.
+
+[Evidence Data]
+(1) A study in guinea pigs reported this substance at doses of 0.25-1 mg/kg, to be severely irritating to the skin, with moderate edema developing within 24 hours, in addition to necrosis and eschar formation (NICNAS IMAP (Access on August 2019)).
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,Cc1ccc(O)cc1C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J43.457D,J-GLOBAL,Cc1ccc(O)cc1C,Train,1,2702,testing
+"EU_REACH:
+2,4-dimethylaniline",,95-68-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2085/7/4/2/?documentUUID=ea2ae5de-666a-4d65-84b6-8aca18e768a8,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=C(C=C1)N)C,https://pubchem.ncbi.nlm.nih.gov/compound/7250,PubChem,Cc1ccc(N)c(C)c1,Train,1,2702,testing
+"NZ_CCID:
+Methylhydroquinone","NZ_CCID:
+1,4-Benzenediol, 2-methyl-",95-71-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D171E28E-AD97-4A79-BAB7-9BB8E7A52DC3,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Sigma Aldrich]
+Eye Irritation
+R PHRASE: R 36 [Sigma Aldrich]",,NZ_CCID,1,CC1=C(C=CC(=C1)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7253,PubChem,Cc1cc(O)ccc1O,Train,1,2702,testing
+"KR_NCIS:
+3-Hydroxy-1,1-dimethylbutyl peroxyneodecanoate","KR_NCIS:
+1,1-Dimethyl-3-hydroxybutyl peroxyneodecanoate; 3-Hydroxy-1,1-dimethylbutyl peroxyneodecanoate; Neodecaneperoxoic acid, 3-hydroxy-1,1-dimethylbutyl ester",95718-78-8,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CC(CC(C)(C)OOC(=O)CCCCCC(C)(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/44146930,PubChem,CC(O)CC(C)(C)OOC(=O)CCCCCC(C)(C)C,Train,1,2702,testing
+"JP_CHRIP:
+2,4-Dichlorotoluene","JP_CHRIP:
+2,4-Dichloro-1-methylbenzene
+Benzene, 2,4-dichloro-1-methyl-
+Toluene, 2,4-dichloro-",95-73-8,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0137e.html,"JP_CHRIP:
+In a skin irritation study using rabbits according to the U.S. guidelines (Code of Federal Regulations, Title 16, Section 1500.41), moderate irritation was observed. Therefore, this substance was classified in Category 2.
+Besides, irritation is also observed in humans although no details are available (Environmental Risk Assessment for Chemical Substances vol.8 (Ministry of the Environment, 2010), HSDB (Access on August 2016)).",,JP_CHRIP,1,Cc1ccc(Cl)cc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.568H,J-GLOBAL,Cc1ccc(Cl)cc1Cl,Train,1,2702,testing
+"JP_CHRIP:
+3,4-Dichlorotoluene",,95-75-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0049e.html,"JP_CHRIP:
+Based on the test results as non-irritant after applying 0.5 mL of the test substance for 4 hours on rabbit skin (OECD TG 404) (ECHA (Access on December 2016)), it is classified as ""Not classified.""",Provided,JP_CHRIP,1,Cc1ccc(Cl)c(Cl)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.570J,J-GLOBAL,Cc1ccc(Cl)c(Cl)c1,Train,1,2702,testing
+"EU_REACH:
+4'-ethyl-3-fluoro-4-(4-propylphenyl)-1,1'-biphenyl",,95759-44-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21014/7/4/2/?documentUUID=1958b2b6-90ab-4e44-8283-74658fd64170,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1=CC=C(C=C1)C2=C(C=C(C=C2)C3=CC=C(C=C3)CC)F,https://pubchem.ncbi.nlm.nih.gov/compound/1715558,PubChem,CCCc1ccc(-c2ccc(-c3ccc(CC)cc3)cc2F)cc1,Train,1,2702,testing
+"JP_CHRIP:
+3,4-dichloroaniline","JP_CHRIP:
+1-Amino-3,4-dichlorobenzene
+3,4-Dichlorobenzenamine
+Benzenamine, 3,4-dichloro-",95-76-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-meti-0014e.html,"JP_CHRIP:
+Since there are descriptions, ""slightly irritating, erythema grade 1, recovery within 2 days"" (EU-RAR (2006), IUCLID (2000)) in the Draize test using rabbits (OECD TG404, GLP) and ""not irritating"" (IUCLID (2000)) in the 24 hour skin irritation test using rabbits, it was classified into ""Not classified"".",Provided,JP_CHRIP,1,Nc1ccc(Cl)c(Cl)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J43.172I,J-GLOBAL,Nc1ccc(Cl)c(Cl)c1,Train,1,2702,testing
+"NZ_CCID:
+3,4-Dichlorophenol",,95-77-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BE6AE8AD-8118-4257-A698-22E67C77CFB2,"NZ_CCID:
+Skin Irritation
+R-PHRASE: R38 [Company Data]
+Eye Irritation
+R-PHRASE: R36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C=C1O)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7258,PubChem,Oc1ccc(Cl)c(Cl)c1,Train,1,2702,testing
+"AU_HCIS:
+Benzenamine, 2,5-dimethyl-",,95-78-3,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5305,,,AU_HCIS,1,CC1=CC(=C(C=C1)C)N,https://pubchem.ncbi.nlm.nih.gov/compound/7259,PubChem,Cc1ccc(C)c(N)c1,Train,1,2702,testing
+"JP_CHRIP:
+2,4-Toluenediamine [2,4-diaminotoluene]","JP_CHRIP:
+2,4-Diaminotoluene
+1,3-Benzenediamine, 4-methyl-
+2,4-Diaminotoluene
+2,4-TDA
+2,4-Toluenediamine
+4-methyl-m-phenylenediamine
+4-methylphenylene-1,3-diamine",95-80-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0094e.html,"JP_CHRIP:
+It was reported that in a skin irritation test with rabbits (OECD TG 404), no irritation was observed by the application of this substance (EU-RAR (2008), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). In addition, it is described with no specific details that this substance is irritating to the skin (Environmental Risk Assessment for Chemical Substances Vol.6 (Ministry of the Environment, 2008)). From the above, this substance was classified as ""Not classified"" (Category 3 in the UN GHS classification) based on the information of the test following the Test Guideline.",Provided,JP_CHRIP,1,Cc1ccc(N)cc1N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.958F,J-GLOBAL,Cc1ccc(N)cc1N,Train,1,2702,testing
+"JP_CHRIP:
+4-chloro-o-phenylenediamine","JP_CHRIP:
+4-Chloro-1,2-phenylenediamine
+3,4-Diaminochlorobenzene
+4-Chloro-o-phenylenediamine
+4-Chloro-ortho-phenylenediamine",95-83-0,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0700e.html,"JP_CHRIP:
+It was classified as Category 2 based on the statement that there is skin irritation on humans (SITTIG (47th, 2002)).",,JP_CHRIP,1,Nc1ccc(Cl)cc1N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.713I,J-GLOBAL,Nc1ccc(Cl)cc1N,Train,1,2702,testing
+"JP_CHRIP:
+2,5-xylenol; 2,5-Dimethylphenol
+
+KR_NCIS:
+2,5-Dimethylphenol
+
+NZ_CCID:
+Phenol, 2,5-dimethyl-","JP_CHRIP:
+2,5-Xylenol
+Phenol, 2,5-dimethyl-
+
+KR_NCIS:
+1,2,5-Xylenol; 1-Hydroxy-2,5-dimethylbenzene; 2,5-Xylenol; 2-Hydroxy-p-xylene; 3,6-Dimethylphenol; 6-Methyl-m-cresol; Hydroxy-p-xylene; Phenol, 2,5-dimethyl-; p-Xylenol",95-87-4,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2027e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D46A5D75-A7A8-4EFA-BE7D-974BDE9D5147","JP_CHRIP:
+[Rationale for the Classification]
+Based on (1), (2), it was classified in Category 1.
+
+[Evidence Data]
+(1) In REACH, the read-across approach can be applied to the category of xylenol isomers, and based on the results of 3,5-xylenol, this substance is also regarded as a corrosive substance (REACH registration dossier (Access on July 2019)).
+(2) It is classified in ""Skin Corr. 1B"" in EU CLP classification (EU CLP classification (Access on July 2019)).
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [NCLASS]
+Eye Irritation
+SPECIES:
+RESULT: Corrosive.
+REFERENCE SOURCE: [NTP]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,Cc1ccc(C)c(O)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J43.459K,J-GLOBAL,Cc1ccc(C)c(O)c1,Train,1,2702,testing
+"JP_CHRIP:
+1,2,4,5-Tetrachlorobenzene","JP_CHRIP:
+Benzene tetrachloride
+s-Tetrachlorobenzene",95-94-3,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0066e.html,"JP_CHRIP:
+It was classified as ""Not classified"" because it is reported that no appreciable irritation was observed in a test by a repeated application of a 10% solution to the ear or abdominal skin of rabbits (BUA 86 (1991)), and it is described that this substance was concluded to be non-irritating in a skin irritation test (OECD TG 404) (BUA 86 (1991)).",Provided,JP_CHRIP,1,Clc1cc(Cl)c(Cl)cc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.573D,J-GLOBAL,Clc1cc(Cl)c(Cl)cc1Cl,Train,1,2702,testing
+"JP_CHRIP:
+2,4,5-trichlorophenol
+
+NZ_CCID:
+2,4,5-Trichlorophenol
+
+US_HSDB:
+2,4,5-TRICHLOROPHENOL","JP_CHRIP:
+1-Hydroxy-2,4,5-trichlorobenzene
+2,4,5-TCP
+Phenol, 2,4,5-trichloro-",95-95-4,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0021e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/78962B54-9235-4B39-8EBC-4A67BA84DBA2
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/4067","JP_CHRIP:
+In rabbit studies, mild to severe cases of erythema were observed, and thus the substance was evaluated as mildly to severely irritating (EHC (1999), DFGOT vol. 12 (1999)). In addition, one human case of erythema, edema, and severe corrosion has been reported, although exposure doses were unspecified (DFGOT vol. 12 (1999)). Taking the EU's R36/38 classification (EU-Annex 1 (accessed in July 2008)) into account, the substance was classified into Category 2.
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [ECB]
+Eye Irritation
+R PHRASE: R 36 [ECB]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,Oc1cc(Cl)c(Cl)cc1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.574B,J-GLOBAL,Oc1cc(Cl)c(Cl)cc1Cl,Train,1,2702,testing
+"EU_REACH:
+2-[2-(4-methylcyclohex-3-en-1-yl)propyl]cyclopentan-1-one",,95962-14-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30194/7/4/2/?documentUUID=7f54fd88-7be6-467a-87c0-fee4d0f64dab,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CCC(CC1)C(C)CC2CCCC2=O,https://pubchem.ncbi.nlm.nih.gov/compound/175661,PubChem,CC1=CCC(C(C)CC2CCCC2=O)CC1,Train,1,2702,testing
+"EU_REACH:
+methyl 1-(3-chloropyridin-2-yl)-3-(hydroxymethyl)-1H-pyrazole-5-carboxylate",,960316-73-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16970/7/4/2/?documentUUID=c6359ae9-4890-4570-8bf7-f9e4831b0ff7,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C1=CC(=NN1C2=C(C=CC=N2)Cl)CO,https://pubchem.ncbi.nlm.nih.gov/compound/53235501,PubChem,COC(=O)c1cc(CO)nn1-c1ncccc1Cl,Train,1,2702,testing
+"JP_CHRIP:
+Phenyloxirane; Styrene Oxide","JP_CHRIP:
+Styrene oxide
+(Epoxyethyl)benzene
+1,2-Epoxyethylbenzene
+Phenyl oxirane
+Phenylethylene oxide
+Phenyloxirane
+stylene oxide
+Styrene epoxide
+Styrene-7,8-oxide",96-09-3,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2047e.html,"JP_CHRIP:
+[Rationale for the Classification]
+It was classified in Category 2 from (1) - (4).
+
+[Evidence Data]
+(1) An undiluted or 1% solution caused moderate irritation (Environmental Risk Assessment for Chemical Substances vol. 4, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2005)).
+(2) It was reported to be irritating in a skin irritation test with rabbits (ACGIH (7th, 2020)).
+(3) Exposure to this substance caused skin and eye irritation in humans (AICIS (formerly, NICNAS) IMAP (2015)).
+(4) Moderate irritation was observed for this substance in humans and animals (GESTIS (Access on May 2020)).
+
+[Reference Data, etc.]
+(5) Short-term exposure irritated the eye and skin, and erythema, pains, and severe burns in the eye and erythema and burns in the skin were seen (Environmental Risk Assessment for Chemical Substances vol. 4, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2005)).",,JP_CHRIP,1,C1OC1c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.159D,J-GLOBAL,c1ccc(C2CO2)cc1,Train,1,2702,testing
+"NZ_CCID:
+1,2,3-Trimethylpropane","NZ_CCID:
+3-methylpentane",96-14-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/53A95180-47EF-4E3B-B9A4-7894E9E6076E,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CCC(C)CC,https://pubchem.ncbi.nlm.nih.gov/compound/7282,PubChem,CCC(C)CC,Train,1,2702,testing
+"JP_CHRIP:
+1,2,3-Trichloropropane","JP_CHRIP:
+1,2,3-Trichloropropane
+Allyl trichloride
+Glycerol trichlorohydrin
+Propane, 1,2,3-trichloro-",96-18-4,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0117e.html,"JP_CHRIP:
+In a skin irritation test (in conformity to OECD TG 404), in which 0.5 mL of test substance was applied to rabbits for 4 hours, mild skin irritation was observed (SIDS (2004)). Therefore, it was classified as ""Not classified"" (corresponding to Category 3 in UN GHS classification).",Provided,JP_CHRIP,1,ClCC(Cl)CCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.962D,J-GLOBAL,ClCC(Cl)CCl,Train,1,2702,testing
+"AU_HCIS:
+1-Butanol, 2-amino-
+
+NZ_CCID:
+2-Amino-1-butanol",,96-20-8,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5539
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/31824D2E-8478-4F6A-9AED-F1374214E4F6","NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,"AU_HCIS, NZ_CCID",2,CCC(CO)N,https://pubchem.ncbi.nlm.nih.gov/compound/22129,PubChem,CCC(N)CO,Train,1,2702,testing
+"JP_CHRIP:
+1,3-Dichloro-2-propanol","JP_CHRIP:
+1,3-Dichloro-2-propanol
+1,3-Dichloro-propan-2-ol
+1,3-Dichloro-propanol-2
+alpha-Dichlorohydrin
+sym-Dichloroisopropyl alcohol
+sym-Glycerol dichlorohydrin",96-23-1,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-2016e.html,"JP_CHRIP:
+It was classified in Category 2 because it was reported to be irritating in a test by 24-hour open application of 0.01 mL of undiluted this substance to rabbits (Initial Risk Assessment Report 201 (NITE, CERI, NEDO, 2008)). Besides, there are also reports that it was mildly irritating or slightly irritating (DFGMAK-Doc (1991), JECFA 1039 (2002)).",,JP_CHRIP,1,OC(CCl)CCl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.964K,J-GLOBAL,OC(CCl)CCl,Train,1,2702,testing
+"NZ_CCID:
+cis-1,2-Bis (phenylsulphonyl) ethylene","NZ_CCID:
+Cis-1,2-bis (phenylsulfonyl) ethylene",963-15-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FD4D05BC-D74C-4F0D-9953-3D24DD73C84E,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)S(=O)(=O)/C=C\S(=O)(=O)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/5383944,PubChem,O=S(=O)(/C=C\S(=O)(=O)c1ccccc1)c1ccccc1,Train,1,2702,testing
+"EU_CLP:
+methyl acrylate; methyl propenoate",,96-33-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,COC(=O)C=C,https://pubchem.ncbi.nlm.nih.gov/compound/7294,PubChem,C=CC(=O)OC,Test,1,2702,testing
+"EU_CLP:
+methyl chloroacetate",,96-34-4,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,COC(=O)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/7295,PubChem,COC(=O)CCl,Test,1,2702,testing
+"EU_REACH:
+3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl 2-chloroprop-2-enoate",,96383-55-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10080/7/4/2/?documentUUID=c618a845-7e18-4373-a433-f6800d8968a4,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=C(C(=O)OCCC(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/59297287,PubChem,C=C(Cl)C(=O)OCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F,Train,1,2702,testing
+"EU_REACH:
+1,3-dioxolan-2-one",,96-49-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14909/7/4/2/?documentUUID=d8a418a1-a143-4dbb-99f6-8549c99f4f82,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1COC(=O)O1,https://pubchem.ncbi.nlm.nih.gov/compound/7303,PubChem,O=C1OCCO1,Train,1,2702,testing
+"EU_REACH:
+4-trans-ethyl-4'-trans-propyl-[1,1'-bicyclohexyl]",,96624-41-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27175/7/4/2/?documentUUID=03133f81-119c-437d-965b-e5b7cff42129,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2CCC(CC2)CC,https://pubchem.ncbi.nlm.nih.gov/compound/19850402,PubChem,CCCC1CCC(C2CCC(CC)CC2)CC1,Train,1,2702,testing
+"EU_REACH:
+4-trans-Butyl-4'-trans-propyl-[1,1'-bicyclohexyl]",,96624-52-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27171/7/4/2/?documentUUID=7db757dd-d416-4694-8516-85ff88745425,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC1CCC(CC1)C2CCC(CC2)CCC,https://pubchem.ncbi.nlm.nih.gov/compound/11086663,PubChem,CCCCC1CCC(C2CCC(CCC)CC2)CC1,Train,1,2702,testing
+"EU_REACH:
+3-[benzyl({4-[2-(4-nitrophenyl)diazen-1-yl]phenyl})amino]propanenitrile",,96662-24-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12107/7/4/2/?documentUUID=3df49d34-3273-4803-8110-a8b6d0fd9485,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)CN(CCC#N)C2=CC=C(C=C2)N=NC3=CC=C(C=C3)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/15869329,PubChem,N#CCCN(Cc1ccccc1)c1ccc(N=Nc2ccc([N+](=O)[O-])cc2)cc1,Train,1,2702,testing
+"EU_REACH:
+2,4-di-tert-butylphenol
+
+JP_CHRIP:
+2,4-Di-tert-butylphenol
+
+NZ_CCID:
+2,4-Di-t-butylphenol
+
+US_HSDB:
+2,4-Di-tert-butylphenol","NZ_CCID:
+2,4-di-tert-butylphenol, Phenol, 2,4-bis(1,1-dimethylethyl)-",96-76-4,Cat 2,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14828/7/4/2/?documentUUID=b13186cc-e355-415f-b368-a0d62c4ab5c1
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-meti-0006e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6D4576F7-FC67-474B-BF79-23D06F008E9B
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8453","EU_REACH:
+Experimental study (OECD TG 404, GLP)
+
+JP_CHRIP:
+In a skin irritation test using rabbits (OECD TG 404), there is a report that moderate irritation was observed (ECHA (Access on November 2016)). Therefore, this substance was classified in Category 2. The data in IUCLID which was used for the previous classification was not adopted because it could not be obtained.
+Besides, in a test in which this substance was applied for 24 hours to rabbit skin, it is reported that corrosivity was shown (Hazard Assessment Report (CERI, NITE, 2009)). However, this was not adopted for the classification because it is a 24-hour application test.
+
+NZ_CCID:
+Skin Irritation
+R-PHRASE: R 38 Irritating to skin. [Degussa fine chemicals MSDS for Ionox 75]
+Eye Irritation
+R-PHRASE: R 36 Irritating to eyes. [Degussa fine chemicals MSDS for Ionox 75]",Provided,"EU_REACH, JP_CHRIP, NZ_CCID, US_HSDB",4,CC(C)(C)c1ccc(O)c(c1)C(C)(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.557A,J-GLOBAL,CC(C)(C)c1ccc(O)c(C(C)(C)C)c1,Train,1,2702,testing
+"NZ_CCID:
+2-Hydroxy-5-nitrobenzoic acid",,96-97-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4A2A20F6-3527-4FEC-9FD3-A827A63E5273,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C=C1[N+](=O)[O-])C(=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7318,PubChem,O=C(O)c1cc([N+](=O)[O-])ccc1O,Train,1,2702,testing
+"EU_REACH:
+4-methyl-3-nitrobenzoic acid",,96-98-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5345/7/4/2/?documentUUID=2c363557-c8ce-4f99-9472-c39aa4748c9b,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)C(=O)O)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/7319,PubChem,Cc1ccc(C(=O)O)cc1[N+](=O)[O-],Train,1,2702,testing
+"NZ_CCID:
+4-Chloro-3-nitrobenzoic acid",,96-99-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2E730A47-3F06-43F5-A73A-19032A8749AD,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C=C1C(=O)O)[N+](=O)[O-])Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7320,PubChem,O=C(O)c1ccc(Cl)c([N+](=O)[O-])c1,Train,1,2702,testing
+"JP_CHRIP:
+1-Chloro-2,4-dinitrobenzene","JP_CHRIP:
+1-Chloro-2,4-dinitrobenzene
+1,3-Dinitro-4-chlorobenzene
+2,4-Dinitrophenyl chloride
+Benzene, 1-chloro-2,4-dinitro-
+DNCB",97-00-7,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-2018e.html,"JP_CHRIP:
+It was highly irritating in a test by 24-hour occlusive application to the rabbit skin (IUCLID (2000)). Furthermore, it is described that this substance is one of the strongest primary skin irritants known (Contact Dermatitis (Frosch) (5th, 2011), corresponding to List 1), and it causes contact dermatitis in humans, and signs such as itchiness, vesicular papules, and skin detachment were observed (Environmental Risk Assessment for Chemical Substances vol. 3 (Ministry of the Environment, 2004)). Therefore, it was classified in Category 2.",,JP_CHRIP,1,[O-][N+](=O)c1ccc(Cl)c(c1)[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.974H,J-GLOBAL,O=[N+]([O-])c1ccc(Cl)c([N+](=O)[O-])c1,Train,1,2702,testing
+"EU_REACH:
+4-[4-(prop-2-en-1-yloxy)benzenesulfonyl]phenol",,97042-18-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13018/7/4/2/?documentUUID=9eeae5f6-2fff-4891-af9c-5426ae538003,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CCOC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(C=C2)O,https://pubchem.ncbi.nlm.nih.gov/compound/2054598,PubChem,C=CCOc1ccc(S(=O)(=O)c2ccc(O)cc2)cc1,Test,1,2702,testing
+"NZ_CCID:
+Benzoic acid, 2-hydroxy-5-sulpho-",,97-05-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/002E9059-975E-4234-8FF5-7D6A59A6BBD8,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [CHEMWATCH]
+Eye Irritation
+R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C1=CC(=C(C=C1S(=O)(=O)O)C(=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7322,PubChem,O=C(O)c1cc(S(=O)(=O)O)ccc1O,Train,1,2702,testing
+"NZ_CCID:
+Bithionol",,97-18-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F43EA5FA-73B7-4960-9D7C-8C1A7045A066,"NZ_CCID:
+Skin Irritation
+SPECIES:
+RESULT: Irritant. It has caused photoallergic contact dermatitis. ""Transient contact"" reactions or ""persistent light reactions"" may occur following dermal exposure.
+REFERENCE SOURCE: Reynolds, J.E.F., Prasad, A.B. (eds.) Martindale-The Extra Pharmacopoeia. 28th ed. London: The Pharmaceutical Press, 1982. 550. **QC REVIEWED** [HSDB]
+Eye Irritation
+EXPERT JUDGEMENT: Assumed to be an eye irritant as it is a skin irritant.",,NZ_CCID,1,C1=C(C=C(C(=C1SC2=C(C(=CC(=C2)Cl)Cl)O)O)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/2406,PubChem,Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O,Train,1,2702,testing
+"EU_REACH:
+4-methoxy-3-nitro-N-phenylbenzamide",,97-32-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17472/7/4/2/?documentUUID=784cd733-ef89-4649-b2e6-8b73600f1df3,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=C(C=C(C=C1)C(=O)NC2=CC=CC=C2)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/7331,PubChem,COc1ccc(C(=O)Nc2ccccc2)cc1[N+](=O)[O-],Test,1,2702,testing
+"EU_REACH:
+(1r,1's,4r,4'r)-4-methoxy-4'-propyl-1,1'-bi(cyclohexane)",,97398-80-6,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30703/7/4/2/?documentUUID=f533647f-a9aa-4030-b654-a93a6ecbdb2c,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC1CCC(CC1)C2CCC(CC2)OC,https://pubchem.ncbi.nlm.nih.gov/compound/556851,PubChem,CCCC1CCC(C2CCC(OC)CC2)CC1,Train,1,2702,testing
+"NZ_CCID:
+2-Hydroxy-5-nitrobenzaldehyde",,97-51-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CB06CDA9-CAF4-4680-A05D-7F6E72C5CE27,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C=C1[N+](=O)[O-])C=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/66808,PubChem,O=Cc1cc([N+](=O)[O-])ccc1O,Train,1,2702,testing
+"JP_CHRIP:
+4-Nitro-o-anisidine","JP_CHRIP:
+4-Nitro-o-anisidine",97-52-9,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2017e.html,"JP_CHRIP:
+Based on a report that in a skin irritation test with rabbits, no irritation was observed in the application of 500 mg of this substance (NTP IMM98007 (2011) (Access on May 2017)), it was classified as ""Not classified."" Besides, there is a description in the information source in List 3 that no irritation tests with rabbits (according to OECD TG 404) (GESTIS (Access on May 2017)).",Provided,JP_CHRIP,1,COc1cc(ccc1N)[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J96.207D,J-GLOBAL,COc1cc([N+](=O)[O-])ccc1N,Train,1,2702,testing
+"AU_HCIS:
+Phenol, 2-methoxy-4-(1-propenyl)-
+
+JP_CHRIP:
+Isoeugenol
+
+NZ_CCID:
+Phenol, 2-methoxy-4-(1-propenyl)-","NZ_CCID:
+Isoeugenol, 1-Hydroxy-2-methoxy-4-propen-1-ylbenzene, 3-Methoxy-4-hydroxy-1-propen-1-ylbenzene, 4-Hydroxy-3-methoxypropenylbenzene, 4-Propenylguaiacol",97-54-1,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5423
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0070e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B343221D-7772-474D-9EDF-11D646ABAE4B","JP_CHRIP:
+From ""severely irritating"" concluded by 24-hour occlusive application with undiluted this substance to rabbit or guinea pig skin (HERA (2005)), it was classified in Category 2.
+Besides, in human, a 48-hour occlusive application test with 32% solution of this compound in acetone in adult males reported that 1 out of 50 men showed moderately irritating. (HERA (2005))
+
+NZ_CCID:
+Skin Irritation
+SPECIES: Human
+RESULT: Moderate
+REFERENCE SOURCE: (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976 [RTECS]
+Eye Irritation
+EXPERT JUDGEMENT: As compound is a skin irritant it is also expected to be eye irritant.",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,COc1cc(C=CC)ccc1O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.221B,J-GLOBAL,CC=Cc1ccc(O)c(OC)c1,Train,1,2702,testing
+"NZ_CCID:
+2-Methylpentanoic acid",,97-61-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F02F6EDF-E0A6-46F0-AE49-69832589F52D,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCCC(C)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7341,PubChem,CCCC(C)C(=O)O,Train,1,2702,testing
+"EU_CLP:
+ethyl methacrylate",,97-63-2,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCOC(=O)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/7343,PubChem,C=C(C)C(=O)OCC,Test,1,2702,testing
+"JP_CHRIP:
+Isobutyric anhydride
+
+NZ_CCID:
+2-Methylpropionic anhydride","NZ_CCID:
+iso-butyric anhydride",97-72-3,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0158e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/166DD4DA-022D-40BA-B0F2-2B797880CE43","JP_CHRIP:
+The substance is rapidly hydrolyzed to isobutyric acid by contact with water (SIDS (J) (Access on Sep. 2010)). Thus, the substance was classified as Category 1 based on the document that open application of isobutyric acid to rabbit skin caused some necrosis within 24 hours (PATTY, 5th (2001)).
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,CC(C)C(=O)OC(=O)C(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J38.161F,J-GLOBAL,CC(C)C(=O)OC(=O)C(C)C,Train,1,2702,testing
+"JP_CHRIP:
+Tetraethylthiuram disulfide (Disulfiram)","JP_CHRIP:
+1,1'-Dithiobis(N,N-diethylthioformamide)
+bis-(N,N-Diethylthiocarbamoyl)disulfide
+Disulfiram
+TETD
+Tetraethylthiuramdisulfide",97-77-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2003e.html,"JP_CHRIP:
+[Rationale for the Classification]
+Based on evidence (1)-(4) that this substance is not skin irritating, it was classified as ""Not classified.""
+
+[Evidence Data]
+(1) There is a report that a drunken-like effect was seen due to exposure with workers at a manufacturing plant, but it is also known that skin irritation is generally seen at the time of perspiration, and minimal skin irritation was observed in only 9% of the overall. In addition, exposure concentrations were not determined (ACGIH (7th, 2001)).
+(2) There is a report that in a skin irritation test (corresponds to OECD TG 404, n=6) with rabbits, when this substance was applied for 4 hours, PII (skin primary irritation index) was 0.13 (maximum 8) (NICNAS IMAP (Accessed Jun. 2018), REACH registration dossier (Accessed Jun. 2018))
+(3) There is a report that in a skin irritation test (corresponds to OECD TG 404, GLP-compliant) with rabbits, when this substance was applied for 24 hours, the erythema score was 0.25, but recovery was complete in 3 days, and the edema score was 0 (NICNAS IMAP (Accessed Jun. 2018), REACH registration dossier (Accessed Jun. 2018)).
+(4) There is a report that in a skin irritation test (corresponds to OECD TG 404, GLP-compliant) with rabbits, when this substance was applied for 24 hours, the erythema score was 0.96, but recovery was complete in 7 days, and the edema score was 0 (NICNAS IMAP (Accessed Jun. 2018), REACH registration dossier (Accessed Jun. 2018)).",Provided,JP_CHRIP,1,CCN(CC)C(=S)SSC(=S)N(CC)CC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.980B,J-GLOBAL,CCN(CC)C(=S)SSC(=S)N(CC)CC,Train,1,2702,testing
+"EU_REACH:
+methyl 2-[[4-ethoxy-6-(methylamino)-1,3,5-triazin-2-yl]carbamoylsulfamoyl]benzoate",,97780-06-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20802/7/4/2/?documentUUID=bb417d49-fab8-41e6-a350-6bd3c59c9602,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=NC(=NC(=N1)NC(=O)NS(=O)(=O)C2=CC=CC=C2C(=O)OC)NC,https://pubchem.ncbi.nlm.nih.gov/compound/91756,PubChem,CCOc1nc(NC)nc(NC(=O)NS(=O)(=O)c2ccccc2C(=O)OC)n1,Train,1,2702,testing
+"AU_HCIS:
+isobutyl methacrylate
+
+JP_CHRIP:
+Isobutyl methacrylate","AU_HCIS:
+2-Propenoic acid, 2-methyl-, 2-methylpropyl ester",97-86-9,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=2648
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2098e.html","JP_CHRIP:
+There is a description that in a skin irritation test with rabbits, when this substance was applied for 2 hours, mild irritation was seen at a primary skin irritation index of 1.87 (SIDS (2009)). In addition, it was described that in two tests in which this substance was applied to rabbits for 24 hours, it was moderately irritating at a primary skin irritation index of 4.16, and it was slightly irritating at a primary skin irritation index of 1.83 (both ECETOC JACC (1996), SIDS (2009)). Since it was considered that this substance was irritating from these results, this substance was classified in Category 2. Besides, this substance was classified as ""Skin Irrit. 2, H315"" in the EU CLP classification (ECHA CL Inventory (Access on August 2017)).",,"AU_HCIS, JP_CHRIP",2,CC(C)COC(=O)C(=C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J47.810E,J-GLOBAL,C=C(C)C(=O)OCC(C)C,Train,1,2702,testing
+"ChemSkin:
+Butyl methacrylate
+
+EU_CLP:
+n-butyl methacrylate
+
+EU_REACH:
+butyl methacrylate",,97-88-1,Cat 2,"ChemSkin: https://doi.org/10.3390/toxics9110314
+EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18
+EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15151/7/4/2/?documentUUID=80114faa-bc9f-4bc9-88af-9cdf30d719e1","ChemSkin:
+Experimental study (OECD TG 404)
+
+EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,"ChemSkin, EU_CLP, EU_REACH",3,CCCCOC(=O)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/7354,PubChem,C=C(C)C(=O)OCCCC,Test,1,2702,testing
+"EU_REACH:
+2-chloro-1,1-dimethoxyethane",,97-97-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17184/7/4/2/?documentUUID=a82e2414-69a9-4b74-8509-a41746bfe512,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(CCl)OC,https://pubchem.ncbi.nlm.nih.gov/compound/60986,PubChem,COC(CCl)OC,Train,1,2702,testing
+"JP_CHRIP:
+tetrahydro-2-furylmethanol; tetrahydrofurfuryl alcohol","JP_CHRIP:
+2-Hydroxymethyl oxolane
+Tetrahydro-2-furancarbinol
+Tetrahydro-2-furanmethanol
+Tetrahydro-2-furylmethanol
+Tetrahydrofurfuryl alcohol",97-99-4,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0022e.html,"JP_CHRIP:
+Since the substance is documented as moderately irritating to guinea pigs and humans (SIDS (2005), PATTY (5th, 2001), it was classified into Category 2.",,JP_CHRIP,1,OCC1CCCO1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.733C,J-GLOBAL,OCC1CCCO1,Train,1,2702,testing
+"JP_CHRIP:
+Furfuryl alcohol
+
+NZ_CCID:
+Furfuryl alcohol","JP_CHRIP:
+2-Furancarbinol
+2-Furanmethanol
+2-Hydroxymethylfuran
+Furfural alcohol
+
+NZ_CCID:
+2-Furancarbinol, 2-Furanmethanol, 2-Furanylmethanol, 2-Furfuryl alcohol, 2-Furylcarbinol, 2-Furylmethanol, 2-Hydroxymethylfuran, 5-Hydroxymethylfuran, Furfural alcohol, Furfuralcohol, Furfuranol",98-00-0,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2030e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BE9E2541-B7A6-45D6-81C1-BA696C961D81","JP_CHRIP:
+[Rationale for the Classification]
+It was classified in Category 2 from (1), (2).
+
+[Evidence Data]
+(1) This substance was irritating to the skin and eyes in rabbits (MAK (DFG) (2016), EU REACH CoRAP (2018)).
+(2) This substance irritated the skin in an animal test (AICIS IMAP (2016)).
+
+NZ_CCID:
+Skin Irritation
+SPECIES: Female mouse (Balb/c)
+RESULT: 75% furfuryl alcohol caused significant
+Skin Irritation, measured as a function of induced increases in ear thickness
+REFERENCE SOURCE: Franko J et al, 2012, Evaluation of furfuryl alcohol sensitisation potential following dermal and pulmonary exposure: Enhancement of airway responsiveness. Combined irritancy local lymph node assay (LLNA).
+RELIABILITY (KLIMISCH SCORE): 1
+Eye Irritation
+SPECIES: rabbit
+RESULT: Half of the required dose resulted in inflammation, viscid mucoid secretion, corneal opacity and eyelid swelling in all animals, with recovery after 40-64 days
+REFERENCE SOURCE: weight of evidence is used; three studies available.",,"JP_CHRIP, NZ_CCID",2,OCc1ccco1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.578E,J-GLOBAL,OCc1ccco1,Train,1,2702,testing
+"JP_CHRIP:
+tert-Butylbenzene","JP_CHRIP:
+Benzene, (1,1-dimethylethyl)-",98-06-6,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0114e.html,"JP_CHRIP:
+On the basis that it was assessed as severely irritating with a primary irritation index of 5.4 (maximum 8) in an occlusive test (OECD TG 404) applied 0.5 mL of undiluted this substance to rabbits for 4 hours (BUA 234 (2001)), it was classified in Category 2.",Provided,JP_CHRIP,1,CC(C)(C)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J43.279B,J-GLOBAL,CC(C)(C)c1ccccc1,Train,1,2702,testing
+"EU_CLP:
+α,α,α-trichlorotoluene; benzotrichloride",,98-07-7,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC=C(C=C1)C(Cl)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7367,PubChem,ClC(Cl)(Cl)c1ccccc1,Test,1,2702,testing
+"JP_CHRIP:
+Benzenesulfonyl chloride
+
+NZ_CCID:
+Benzenesulphonyl chloride",,98-09-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0094e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/15891980-7B2F-49FA-9776-0F56221A1F4B","JP_CHRIP:
+Based on a result of ""corrosive"" in a rabbit test (IUCLID (2000)), the substance was classified into Category 1.
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,ClS(=O)(=O)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.983G,J-GLOBAL,O=S(=O)(Cl)c1ccccc1,Train,1,2702,testing
+"JP_CHRIP:
+Benzenesulfonic acid
+
+NZ_CCID:
+Benzenesulphonic acid","JP_CHRIP:
+Benzenemonosulfonic acid
+Phenylsulfonic acid",98-11-3,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0071e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E6F359F2-D929-4675-A78E-45582CC9C70B","JP_CHRIP:
+It was classified in Category 1 because there is a description of severe skin irritation in guinea pigs (HSDB (2002)), and the saturated solution of this substance has pH 2.
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [CHEMWATCH]
+Eye Irritation
+R PHRASE: R 41 [CHEMWATCH]",,"JP_CHRIP, NZ_CCID",2,OS(=O)(=O)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J62.182J,J-GLOBAL,O=S(=O)(O)c1ccccc1,Train,1,2702,testing
+"JP_CHRIP:
+Trichlorophenylsilane",,98-13-5,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0011e.html,"JP_CHRIP:
+It was classified in Category 1 base on a result as ""highly corrosive"" in a rabbit test (IUCLID (2000)) and a result indicating ""corrosion"" in another rabbit test (HSDB (2000)).",,JP_CHRIP,1,Cl[Si](Cl)(Cl)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J54.322E,J-GLOBAL,Cl[Si](Cl)(Cl)c1ccccc1,Train,1,2702,testing
+"EU_REACH:
+1-chloro-3-(trifluoromethyl)benzene",,98-15-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19799/7/4/2/?documentUUID=da93ee4f-47e1-45f8-8309-595e50d30ad6,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC(=C1)Cl)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/7374,PubChem,FC(F)(F)c1cccc(Cl)c1,Train,1,2702,testing
+"NZ_CCID:
+3-Aminobenzotrifluoride",,98-16-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/86673896-5F1C-4A03-B5EE-B32D622AAAD1,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)N)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/7375,PubChem,Nc1cccc(C(F)(F)F)c1,Train,1,2702,testing
+"AU_HCIS:
+1,2-Benzenediol, 4-(1,1-dimethylethyl)-
+
+NZ_CCID:
+4-t-Butylpyrocatechol","NZ_CCID:
+4-tert-butylcatechol",98-29-3,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6586
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/779E6331-F4AE-4B13-9B1B-352BDCAA6AB2","NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,"AU_HCIS, NZ_CCID",2,CC(C)(C)C1=CC(=C(C=C1)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7381,PubChem,CC(C)(C)c1ccc(O)c(O)c1,Train,1,2702,testing
+"EU_REACH:
+ethyl 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate",,98349-25-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10623/7/4/2/?documentUUID=2291aa59-18ef-485e-a4f1-205ef78b096e,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1=CN(C2=CC(=C(C=C2C1=O)F)F)C3CC3,https://pubchem.ncbi.nlm.nih.gov/compound/9817544,PubChem,CCOC(=O)c1cn(C2CC2)c2cc(F)c(F)cc2c1=O,Train,1,2702,testing
+"EU_REACH:
+trans-1,4-bis(isocyanatomethyl)cyclohexane",,98458-83-4,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26702/7/4/2/?documentUUID=fecb723c-8202-4de1-bb82-06bf9427fb51,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC(CCC1CN=C=O)CN=C=O,https://pubchem.ncbi.nlm.nih.gov/compound/61504,PubChem,O=C=NCC1CCC(CN=C=O)CC1,Train,1,2702,testing
+"AU_HCIS:
+4-tert-butylphenol
+
+EU_REACH:
+4-tert-butylphenol
+
+JP_CHRIP:
+4-tert-Butylphenol
+
+NZ_CCID:
+Phenol, 4-(1,1-dimethylethyl)-
+
+US_HSDB:
+p-tert-Butylphenol","AU_HCIS:
+Phenol, 4-(1,1-dimethylethyl)-
+
+JP_CHRIP:
+1-Hydroxy-4-tert-butylbenzene
+4-(1,1-Dimethylethyl)phenol
+p-tert-butylphenol
+Phenol, 4-(1,1-dimethylethyl)-
+
+NZ_CCID:
+1-Hydroxy-4-tert-butylbenzene, 4-(1,1-Dimethylethyl)phenol, 4-t-Butylphenol, 4-tert-Butylphenol, Butylphen, C10-H14-O, PTBP, Phenol, p-(tert-butyl)-, Ucar butylphenol 4-T, p-tert-Butylphenol",98-54-4,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4792
+EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15260/7/4/2/?documentUUID=c1093fe1-8b6f-48ae-ba1c-865ab4239bbc
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-meti-0023e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AA4BAA9F-68E0-4FA1-8ED3-6A538A769FDB
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8434","EU_REACH:
+Experimental study (OECD TG 404, GLP)
+
+JP_CHRIP:
+It is reported that, in a skin irritation test with rabbits (OECD TG 404), severe irritation responses were observed as a result of a 4-hour semi-occlusive application of 500 mg of this substance, and these were resolved within 14 days (EU-RAR (2008)). It is reported that in separate skin irritation tests with rabbits (OECD TG 404), it was irritating (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)), severely irritating (EU-RAR (2008)), and corrosive (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)). In addition, there is a report that, in a skin irritation study with rabbits (US DOT regulation 173.1300), severe irritation or corrosion was observed following a 4-hour semi-occlusive application of 500 mg of this substance (EU-RAR (2008)). There are also descriptions that necrosis, scabbing, and desquamation of the skin were observed following a 4-hour or 24-hour application of 500 mg of this substance but this was resolved by 17 days after administration (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007), EU-RAR (2008), DFGOT Vol. 11 (1998)). In the EU-RAR (2008), it is regarded that this substance is severely irritating to the skin. From the above, this substance was classified in Category 2.
+
+NZ_CCID:
+Skin Irritation
+SPECIES: Rabbit
+RESULT: Irritating.
+REFERENCE SOURCE: Huels AG Marl (48) [IUCLID]
+Eye Irritation
+SPECIES: Rabbit
+RESULT: Severe
+REFERENCE SOURCE: DCTODJ 11,43,1988 [http://www.cdc.gov/niosh/rtecs/sj882f48.html]
+[RTECS]",Provided,"AU_HCIS, EU_REACH, JP_CHRIP, NZ_CCID, US_HSDB",5,CC(C)(C)c1ccc(O)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.579C,J-GLOBAL,CC(C)(C)c1ccc(O)cc1,Train,1,2702,testing
+"NZ_CCID:
+3-Cyclohexene-1-methanol, .alpha.,.alpha.,4-trimethyl-
+
+US_HSDB:
+alpha-Terpineol","NZ_CCID:
+p-menth-1-en-8-ol",98-55-5,Cat 2,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6A84F94A-5DA3-416A-A4A8-4A881B24B895
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/5316","NZ_CCID:
+Skin Irritation
+In rabbits neat alpha-terpineol was a moderate skin irritant. Two dermatitis patients were reported to be sensitized to alpha-terpineol, although attempts to induce skin sensitization in volunteers and guinea pigs using a dilute solution were unsuccessful. Following acute oral exposure, a low toxicity was generally reported in rodents. Indirect evidence of liver effects was seen in rats given repeated oral doses. No indication of lung carcinogenicity was seen in a limited study in mice (treated by injection). A mutagenic effect was seen in sensitive strains in an Ames bacterial test.
+alpha-Terpineol
+Authors:
+BIBRA working group
+Source: TA:Toxicity profile. TNO BIBRA International PG: YR:2001 IP: VI:
+[TOXLINE]
+Eye Irritation
+AS JUDGED BY PINE OIL, TERPINEOLS ARE IRRITATING TO EYES & MUCOUS MEMBRANES. PRODUCE HEMORRHAGIC GASTRITIS WHEN INGESTED. SYSTEMIC EFFECTS INCLUDE WEAKNESS & CENTRAL NERVOUS DEPRESSION, WITH HYPOTHERMIA & RESPIRATORY FAILURE. /TERPINEOLS/
+[Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984.,p. II-260]**PEER REVIEWED**[HSDB]",,"NZ_CCID, US_HSDB",2,CC1=CCC(CC1)C(C)(C)O,https://pubchem.ncbi.nlm.nih.gov/compound/17100,PubChem,CC1=CCC(C(C)(C)O)CC1,Train,1,2702,testing
+"NZ_CCID:
+4-Bromobenzenesulphonyl chloride",,98-58-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2893EFAD-9CC9-4251-834A-0027964E8BE9,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1S(=O)(=O)Cl)Br,https://pubchem.ncbi.nlm.nih.gov/compound/7396,PubChem,O=S(=O)(Cl)c1ccc(Br)cc1,Train,1,2702,testing
+"NZ_CCID:
+4-Toluenesulphonyl chloride","NZ_CCID:
+4-Methylbenzenesulfonyl chloride, 4-Toluenesulfonyl chloride, Benzenesulfonyl chloride, 4-methyl-, Tosyl chloride, p-Methylbenzenesulfonyl chloride, p-Toluenesulfochloride, p-Toluenesulfonic acid chloride, p-Toluenesulphonyl chloride, p-Tolylsulfonyl chloride, p-Tosyl chloride, para-Toluenesulfonyl chloride",98-59-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/38C8068C-2B7E-4CA4-AB65-012C913832B8,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC1=CC=C(C=C1)S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7397,PubChem,Cc1ccc(S(=O)(=O)Cl)cc1,Train,1,2702,testing
+"NZ_CCID:
+4-Chlorobenzenesulphonyl chloride",,98-60-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4168693B-5296-46E1-89C3-386A788C54E0,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1S(=O)(=O)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7398,PubChem,O=S(=O)(Cl)c1ccc(Cl)cc1,Train,1,2702,testing
+"EU_REACH:
+4-hydroxybenzenesulfonic acid",,98-67-9,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18559/7/4/2/?documentUUID=56597e61-f1e0-4fc5-bef8-dddd378b2253,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1O)S(=O)(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/4765,PubChem,O=S(=O)(O)c1ccc(O)cc1,Test,1,2702,testing
+"NZ_CCID:
+4-Methoxybenzenesulphonyl chloride",,98-68-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B4755BD2-F16B-4465-92A1-033F6D04568A,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [CHEMWATCH]
+Eye Irritation
+R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,COC1=CC=C(C=C1)S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7401,PubChem,COc1ccc(S(=O)(=O)Cl)cc1,Train,1,2702,testing
+"NZ_CCID:
+4-Nitrobenzenesulphonyl chloride",,98-74-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D222C6C1-5B24-4F4F-90EF-213D01E3C7BF,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1[N+](=O)[O-])S(=O)(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7404,PubChem,O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1,Train,1,2702,testing
+"JP_CHRIP:
+Cumene","JP_CHRIP:
+(1-Methylethyl)benzene
+1-Methylethylbenzene
+2-Phenylpropane
+isopropylbenzene
+isopropylbenzene [synonym:cumene]",98-82-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-mhlw-2011.html,"JP_CHRIP:
+【分類根拠】
+（１）より、区分に該当しない。
+
+【根拠データ】
+（１）ウサギ（n= 6）を用いた皮膚刺激性試験（OECD TG404相当、無傷／有傷皮膚、72時間観察）では、24及び72時間後の観察で浮腫はみられなかったが、軽度で回復性のある紅斑が全例にみられた。6例の個体別平均スコア（フルスコア：8）は各々2、1.5、2、2、2及び1.5で無傷皮膚と有傷皮膚には差はなかった（AICIS IMAP (2016)、EU RAR (2001)、ACGIH (7th, 2001)、厚労省 リスク評価書 (2015)、産衛学会 許容濃度暫定値の提案理由書 (2019)、REACH登録情報 (Accessed Dec. 2021)）。
+
+【参考データ等】
+（２）本物質は皮膚刺激性物質である（AICIS IMAP (2016)、NTP(2009)）。
+（３）厚労省 リスク評価書 (2015)では、皮膚刺激性/腐食性：軽度の刺激性とされた。
+（４）ウサギを用いた皮膚刺激性試験（原液0.5 mL、24時間適用）では、皮膚剥離を伴う軽微な脱脂作用がみられ、軽微な皮膚刺激性と判定された（ACGIH (7th, 2001)、厚労省 リスク評価書 (2015)、産衛学会 許容濃度暫定値の提案理由書 (2019)）。",Provided,JP_CHRIP,1,CC(C)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.581E,J-GLOBAL,CC(C)c1ccccc1,Train,1,2702,testing
+"JP_CHRIP:
+alpha-Methylstyrene","JP_CHRIP:
+1-Methyl-1-phenylethylene
+2-phenylpropene
+alpha-methylstylene
+alpha-Methylstyrene
+Isopropenyl benzene",98-83-9,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0072e.html,"JP_CHRIP:
+There is a report that moderate irritation was observed in a skin irritation test (standard Draize test) with rabbits (SIDS (2002)). From the above, based on the descriptions of the moderate irritation, it was classified in Category 2. Besides, after a 24-hour application of 0.5 mL of undiluted solution of this substance, severe erythema, edema, blistering, and skin corrosivity occurred after 24 hours, and the Draize score was 8.0 (maximum value 8.0) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), but this was not used for the classification because it was a 24-hour application test. This substance was classified as ""Skin. Irrit. 2 H315"" in EU CLP classification (ECHA CL Inventory (Access on September 2015)).",,JP_CHRIP,1,CC(=C)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.582C,J-GLOBAL,C=C(C)c1ccccc1,Train,1,2702,testing
+"NZ_CCID:
+1-Phenylethanol",,98-85-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D92BD20E-BF53-41C8-AA27-77388BBFB3B3,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(C1=CC=CC=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/7409,PubChem,CC(O)c1ccccc1,Train,1,2702,testing
+"JP_CHRIP:
+Acetophenone
+
+NZ_CCID:
+Methyl phenyl ketone","JP_CHRIP:
+1-Phenylethanone
+acetphenone
+Acetylbenzene
+Phenyl methyl ketone
+
+NZ_CCID:
+1-Phenyl-1-ethanone, 1-Phenylethanone, Acetophenon, Acetophenone, Acetylbenzene, Benzoyl methide, Benzoylmethide, Ethanone, 1-phenyl-, Hypnone, Phenyl methyl ketone",98-86-2,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2057e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BA188D4E-41BF-4DBB-B11A-49F86FC553A6","JP_CHRIP:
+Based on a description that this substance is irritating to the skin (PATTY (6th, 2012), HSDB (Access on June 2017)), it was classified in Category 2. The category was revised based on information obtained in this survey.
+
+NZ_CCID:
+Skin Irritation
+SPECIES:
+RESULT: Liquid can cause..
+Skin Irritation on contact.
+REFERENCE SOURCE:[U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office, 1984-5.]**QC REVIEWED** [HSDB]
+Eye Irritation
+R-PHRASE: R 36. [N-Class]",,"JP_CHRIP, NZ_CCID",2,CC(=O)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.225E,J-GLOBAL,CC(=O)c1ccccc1,Train,1,2702,testing
+"AU_HCIS:
+α,α-dichlorotoluene
+
+JP_CHRIP:
+Benzene, (dichloromethyl)-
+
+NZ_CCID:
+(Dichloromethyl)benzene","AU_HCIS:
+benzylidene chloride
+benzal chloride
+benzyl dichloride
+chlorobenzal
+
+JP_CHRIP:
+(dichloromethyl)benzene
+alpha, alpha-Dichlorotoluene
+alpha,alpha-Dichlorotoluene
+alpha-Chlorinated toluenes (benzal chloride, benzotrichloride, benzyl chloride) and benzoyl chloride (combined exposures)
+benzal chloride
+Benzyl dichloride
+Benzylidene chloride
+Dichloromethyl benzene
+
+NZ_CCID:
+benzylidene chloride",98-87-3,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1310
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0189e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C14C65F9-48FA-4677-9DDF-27FD54E40F38","JP_CHRIP:
+Since it was evaluated to be ""highly irritating"" in the rabbit skin irritation test (IUCLID 2000) and described to ""seriously stimulate the skin"" as a result of short-term exposure (ICSC (2000)), it was classified as Category 2.
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 41 [Company Data]",,"AU_HCIS, JP_CHRIP, NZ_CCID",3,ClC(Cl)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.986A,J-GLOBAL,ClC(Cl)c1ccccc1,Train,1,2702,testing
+"AU_HCIS:
+benzoyl chloride
+
+JP_CHRIP:
+Benzoyl chloride
+
+KR_NCIS:
+Benzoyl chloride
+
+NZ_CCID:
+Benzoyl chloride
+
+US_HSDB:
+Benzoyl chloride","JP_CHRIP:
+alpha-Chlorinated toluenes (benzal chloride, benzotrichloride, benzyl chloride) and benzoyl chloride (combined exposures)
+alpha-Chlorobenzaldehyde
+Benzenecarbonyl chloride
+Benzoic acid chloride
+
+KR_NCIS:
+Benzenecarbonyl chloride; Benzoic acid chloride
+
+NZ_CCID:
+Benzenecarbonyl chloride, Benzoic acid, chloride",98-88-4,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=457
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2015e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BDEC200B-FA30-411E-A0FD-F2252AD43C67
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/383","JP_CHRIP:
+[Rationale for the Classification]
+Based on (1)-(3), it was judged that this substance is corrosive to the skin, and it was classified in Category 1.
+
+[Evidence Data]
+(1) It is described that this substance is corrosive to humans in multiple articles in literature (NICNAS IMAP (Accessed Aug. 2018), Vincoli (1996), Bruze et al. (2000)).
+(2) In a skin irritation test (n=6) with rabbits, after a 4-hour application followed by 72-hour observation, an irritation score of 3.8 is reported (REACH registration dossier (Accessed Aug. 2018)).
+(3) There is also a report that this substance is very strongly irritating to rabbit skins (Risk Assessment Report (Ministry of Health, Labour and Welfare, 2008), ACGIH (7th, 2001)).
+
+[Reference Data, etc.]
+(4) This substance was classified as ""Skin Corr. 1B"" in the EU CLP.
+
+NZ_CCID:
+Skin Irritation
+R-PHRASE: R 34
+UN CLASS: 8 PG II [ICSC 2000]
+
+Eye Irritation
+EU Classification
+Symbol: C
+R: 34
+S: (1/2-)26-45
+EFFECTS OF SHORT-TERM EXPOSURE:
+Tear drawing. The substance is corrosive to the eyes, the skin and the respiratory tract. Corrosive on ingestion. Inhalation of the vapour or aerosol may cause lung oedema (see Notes).
+[ICSC 2000]",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,ClC(=O)c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.987J,J-GLOBAL,O=C(Cl)c1ccccc1,Train,1,2702,testing
+"NZ_CCID:
+Cyclohexanecarboxylic acid",,98-89-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/72BFEB16-EC9D-4E99-BE97-8F65AFC1F8C8,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1CCC(CC1)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7413,PubChem,O=C(O)C1CCCCC1,Train,1,2702,testing
+"JP_CHRIP:
+N,N-Dimethylcyclohexylamine
+
+NZ_CCID:
+Cyclohexyldimethylamine","JP_CHRIP:
+N,N-Dimethyl-cyclohexylamine
+Cyclohexanamine, N,N-dimethyl-
+Cyclohexylamine, N,N-dimethyl-
+Cyclohexyldimethylamine
+N,N-Dimethylaminocyclohexane
+N-Cyclohexyldimethylamine
+
+NZ_CCID:
+(Dimethylamino)Cyclohexane, N, N-Dimethylcyclohexanamine, N,N-Dimethylcyclohexylamine",98-94-2,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2015e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D1F03E47-69FF-4B3D-BF20-ABA7BDE1E357","JP_CHRIP:
+Based on a report that it was corrosive in a skin irritation test with rabbits, and a description that the 5 g/L aqueous solution of this substance was pH 12 (GESTIS (Access on May 2017)), and that the corrosive properties were attributable to the alkaline properties of the aqueous solution of this substance (SIAP (2012)), it was classified in Category 1.
+
+NZ_CCID:
+Skin Irritation
+N,N-Dimethyl-cyclohexylamine has a specific UN number 2264 Class 8 Sub risk 3 packing group II, with risk phrases R10,R20/21/22,R34.
+Class 8 packing group II is equivalent to an HSNO 8.2B classification.
+Eye Irritation
+N,N-Dimethyl-cyclohexylamine has a specific UN number 2264 Class 8 Sub risk 3 packing group II, with risk phrases R10,R20/21/22,R34.",,"JP_CHRIP, NZ_CCID",2,CN(C)C1CCCCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.960C,J-GLOBAL,CN(C)C1CCCCC1,Train,1,2702,testing
+"NZ_CCID:
+3'-Chloroacetophenone",,99-02-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AB0250A8-3CFA-4B06-B882-7E38A437A9F9,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(=O)C1=CC(=CC=C1)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/14933,PubChem,CC(=O)c1cccc(Cl)c1,Train,1,2702,testing
+"NZ_CCID:
+Benzoic acid, 3,5-dihydroxy-",,99-10-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/80FF9977-59F7-46AE-A920-A1D164141354,,,NZ_CCID,1,C1=C(C=C(C=C1O)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7424,PubChem,O=C(O)c1cc(O)cc(O)c1,Train,1,2702,testing
+"EU_REACH:
+4,4'-Methylenebis(N-butoxycarbonylcyclohexanamine)",,99305-42-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20249/7/4/2/?documentUUID=e113222c-646e-45bf-b87e-8df97c8f14f8,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCOC(=O)NC1CCC(CC1)CC2CCC(CC2)NC(=O)OCCCC,https://pubchem.ncbi.nlm.nih.gov/compound/11742316,PubChem,CCCCOC(=O)NC1CCC(CC2CCC(NC(=O)OCCCC)CC2)CC1,Train,1,2702,testing
+"EU_REACH:
+trimethylsilane",,993-07-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19701/7/4/2/?documentUUID=b97fb748-c412-4f1e-8725-5e76728b4248,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[SiH](C)C,https://pubchem.ncbi.nlm.nih.gov/compound/70435,PubChem,C[SiH](C)C,Train,1,2702,testing
+"NZ_CCID:
+3,5-Dinitrobenzoyl chloride",,99-33-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/42A7A118-D942-47EB-9B2E-063759012F7E,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=C(C=C(C=C1[N+](=O)[O-])[N+](=O)[O-])C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7432,PubChem,O=C(Cl)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1,Train,1,2702,testing
+"JP_CHRIP:
+tert-Amyl methyl ether [TAME or 2-methoxy-2-methylbentane]","JP_CHRIP:
+1,1-Dimethyl propylmethyl ether
+2-Methyl-2-methoxybutane
+Butane, 2-methoxy-2-methyl-
+Methyl-tert-pentyl ether
+TAME
+tert-Pentyl methyl ether",994-05-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0020e.html,"JP_CHRIP:
+In a skin irritation test using rabbits (OECD TG 404, GLP compliance), 4-hour application with 500 micro L this substance (98.4%) resulted in the irritation score of 0, and it was judged to be not irritating (EU-RAR (2006)). From the above result, it was judged to be ""Not classified.""",Provided,JP_CHRIP,1,CCC(C)(C)OC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J125.007H,J-GLOBAL,CCC(C)(C)OC,Train,1,2702,testing
+"EU_REACH:
+chlorotriethylsilane
+
+NZ_CCID:
+Chlorotriethylsilane",,994-30-9,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19870/7/4/2/?documentUUID=0376eda7-1481-43e3-a105-965f183d3948
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/12EB044C-011B-450A-B037-2351BF6AA3D1","EU_REACH:
+Experimental study (OECD TG 404, GLP)
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",Provided,"EU_REACH, NZ_CCID",2,CC[Si](CC)(CC)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/13819,PubChem,CC[Si](Cl)(CC)CC,Train,1,2702,testing
+"NZ_CCID:
+Benzoic acid, 3,4-dihydroxy-",,99-50-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A3DC3C40-3AE8-4E73-9FA4-40878CCD2E9A,,,NZ_CCID,1,C1=CC(=C(C=C1C(=O)O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/72,PubChem,O=C(O)c1ccc(O)c(O)c1,Train,1,2702,testing
+"JP_CHRIP:
+1,2-Dichloro-4-nitrobenzene","JP_CHRIP:
+1,2-Dichloro-4-nitrobenzene
+3,4-Dichloronitrobenzene
+Benzene, 1,2-dichloro-4-nitro-
+DCNB",99-54-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-meti-0017e.html,"JP_CHRIP:
+Since the 24 hour skin irritation/corrosion test with rabbits (OECD TG 404, GLP) did not identify skin irritation (average scored values for erythema/crust and edema:0.2, 0.0) (SIDS (2003)), it was classified into ""Not classified"".",Provided,JP_CHRIP,1,[O-][N+](=O)c1ccc(Cl)c(Cl)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.584J,J-GLOBAL,O=[N+]([O-])c1ccc(Cl)c(Cl)c1,Train,1,2702,testing
+"NZ_CCID:
+2-Chloro-4-nitrobenzoic acid",,99-60-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D8D22727-9AC8-4E62-A9FC-EFC6FEBA24EB,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=C(C=C1[N+](=O)[O-])Cl)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7448,PubChem,O=C(O)c1ccc([N+](=O)[O-])cc1Cl,Train,1,2702,testing
+"EU_REACH:
+3,4,5-trifluorophenol",,99627-05-1,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/4466/7/4/2/?documentUUID=738c89d3-4675-48a2-aa3a-8b1832b39883,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(C=C(C(=C1F)F)F)O,https://pubchem.ncbi.nlm.nih.gov/compound/2777943,PubChem,Oc1cc(F)c(F)c(F)c1,Train,1,2702,testing
+"NZ_CCID:
+Isophthaloyl dichloride","NZ_CCID:
+iso-phthaloyl chloride",99-63-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3F7D4CB0-BF7D-4AAF-B0F2-EDA47881C2EE,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC(=CC(=C1)C(=O)Cl)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7451,PubChem,O=C(Cl)c1cccc(C(=O)Cl)c1,Train,1,2702,testing
+"JP_CHRIP:
+m-Dinitrobenzene","JP_CHRIP:
+1,3-Dinitrobenzene
+1,3-Dinitrobenzol
+1,3-DNB
+Benzene, 1,3-dinitro-
+dinitrobenzene
+m-Dinitrobenzene",99-65-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2049e.html,"JP_CHRIP:
+[Rationale for the Classification]
+Based on (1) and (2), it was classified as ""Not classified.""
+
+[Evidence Data]
+(1) In a skin irritation test with rabbits according to OECD TG 404, it revealed no irritation (GESTIS (Access on July 2019)).
+(2) Although details were unknown, there is a report that no irritation was observed in a skin irritation test with rabbits (ATSDR (1995)).
+
+[Reference Data, etc.]
+(3) In a skin irritation test with guinea pigs applied with a formulation containing 0.5% of this substance, no irritation was observed (ATSDR (1995)).",Provided,JP_CHRIP,1,[O-][N+](=O)c1cccc(c1)[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.177K,J-GLOBAL,O=[N+]([O-])c1cccc([N+](=O)[O-])c1,Train,1,2702,testing
+"NZ_CCID:
+2-Propylvaleric acid","NZ_CCID:
+Valproic acid",99-66-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/91B25F33-0BA7-4858-976A-CB2D0DE04606,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CCCC(CCC)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/3121,PubChem,CCCC(CCC)C(=O)O,Train,1,2702,testing
+"JP_CHRIP:
+p-sec-Butylphenol","JP_CHRIP:
+4-(1-methylpropyl)phenol
+p-sec-butylphenol",99-71-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0072e.html,"JP_CHRIP:
+In a test by a 4-hour semi-occlusive application of 0.5 mL of the undiluted solution of this substance liquefied by heating to the rabbit skin (GLP-compliant), all six animals showed necrosis, PII (primary irritation index) was 7.25, and it was concluded to be corrosive (HPVIS (2009)). Therefore, it was classified in Category 1.",,JP_CHRIP,1,CCC(C)c1ccc(O)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J362J,J-GLOBAL,CCC(C)c1ccc(O)cc1,Train,1,2702,testing
+"NZ_CCID:
+2,4'-Dibromoacetophenone",,99-73-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EF35CDD3-C8B4-41E2-9F8F-F6B499D9D2D1,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CC(=CC=C1C(=O)CBr)Br,https://pubchem.ncbi.nlm.nih.gov/compound/7454,PubChem,O=C(CBr)c1ccc(Br)cc1,Train,1,2702,testing
+"NZ_CCID:
+Benzene, 1-methyl-4-(1-methylethyl)-","NZ_CCID:
+1-Isopropyl-4-methylbenzene, 2-p-Tolylpropane, 4-Isopropyl toluene, Camphogen, Dolcymene, Paracymene, p-Cymene, p-Methylcumene, p-Methylisopropylbenzene",99-87-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/86EFBAB9-5FFB-4599-9E1D-B72DF6192BFF,"NZ_CCID:
+Skin Irritation
+SPECIES:
+RESULT: Skin irritant that can also defat the skin
+REFERENCE SOURCE: [Peer Reviewed] [Browning,
+E. Toxicity and Metabolism of Industrial Solvents. New York: American Elsevier, 1965. 105]. (HSDB)
+Eye Irritation
+SPECIES:
+RESULT: Vapour non-irritating to eyes. Liquid irritating to eyes.
+REFERENCE SOURCE: [Peer Reviewed] [U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office, 1984-5.] RTECS",,NZ_CCID,1,CC1=CC=C(C=C1)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/7463,PubChem,Cc1ccc(C(C)C)cc1,Train,1,2702,testing
+"JP_CHRIP:
+4-Isopropylaniline","JP_CHRIP:
+4-isopropylaniline",99-88-7,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0013e.html,"JP_CHRIP:
+On the basis of a result as ""corrosive"" in a test using rabbits (OECD TG 404: GLP) (IUCLID (2000), it was classified in Category 1.",Provided,JP_CHRIP,1,CC(C)c1ccc(N)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J11.624F,J-GLOBAL,CC(C)c1ccc(N)cc1,Train,1,2702,testing
+"NZ_CCID:
+4'-Bromoacetophenone",,99-90-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/223CE696-0D7C-4283-B622-19680A374200,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(=O)C1=CC=C(C=C1)Br,https://pubchem.ncbi.nlm.nih.gov/compound/7466,PubChem,CC(=O)c1ccc(Br)cc1,Train,1,2702,testing
+"NZ_CCID:
+4'-Chloroacetophenone",,99-91-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/504E47AC-DA62-456E-ADA6-63D7FE255610,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(=O)C1=CC=C(C=C1)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7467,PubChem,CC(=O)c1ccc(Cl)cc1,Train,1,2702,testing
+"JP_CHRIP:
+2-Hydroxypropyl acrylate
+
+US_HSDB:
+2-Hydroxypropyl acrylate","JP_CHRIP:
+2-Propenoic acid, 2-hydroxypropyl ester
+Acrylic acid, 2-hydroxypropyl ester
+beta-Hydroxypropyl acrylate
+Propylene glycol monoacrylate",999-61-1,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0067e.html
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/7913","JP_CHRIP:
+It is reported that in a skin irritation test using rabbits, moderate edema and moderate to severe necrosis were observed after this substance (170 to 250 mg/kg) was locally applied, and moderate chemical burns were found after application of a 10% aqueous solution (ACGIH (7th, 2001)). Moreover, it is reported that moderate irritation was found after open application of an isomer mixture containing 75% this substance (25% 1-hydroxy-2-propyl acrylate) to rabbit skin (DFGOT vol. 16 (2001)). Furthermore, it is reported that severe deep-seated necrosis was observed after 15-minute or 4-hour occlusive application of an isomer mixture containing 66% this substance (33% 1-hydroxy-2-propyl acrylate, 1% free acrylic acid or 1-hydroxy-3-propyl acrylate) (animal species: unknown) (DFGOT vol. 16 (2001)). From the above reports, the substance was classified in Category 1. Besides, it is classified in ""Skin. Corr. 1B H314"" in EU CLP classification (ECHA CL Inventory (Access on September 2015)).",,"JP_CHRIP, US_HSDB",2,CC(O)COC(=O)C=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J33.773K,J-GLOBAL,C=CC(=O)OCC(C)O,Train,1,2702,testing
+"EU_REACH:
+4-hydroxybenzoic acid",,99-96-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15944/7/4/2/?documentUUID=500bdcb0-2581-4d12-8cfb-3faea4b487c7,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1C(=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/135,PubChem,O=C(O)c1ccc(O)cc1,Train,1,2702,testing
+"EU_REACH:
+(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31R,32R,33R,34R,35R,36R,37R,38R,39R,40R,41R,42R)-5,10,15,20,25,30-Hexakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29-dodecaoxahe ptacyclo[26.2.2.23,6.28,11.213,16.218,21.223,26]dotetracontane-31,32,33,34,35,36,37,38,39,40,41,42-dodecol",,10016-20-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10199/7/4/2/?documentUUID=2e64379f-4aa8-4991-be4c-a0e4ca0a4ad6,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C([C@@H]1[C@@H]2[C@@H]([C@H]([C@H](O1)O[C@@H]3[C@H](O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]4[C@H](O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]5[C@H](O[C@@H]([C@@H]([C@H]5O)O)O[C@@H]6[C@H](O[C@@H]([C@@H]([C@H]6O)O)O[C@@H]7[C@H](O[C@H](O2)[C@@H]([C@H]7O)O)CO)CO)CO)CO)CO)O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/444913,PubChem,OC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O[C@H]1[C@H](O)[C@H]2O)O[C@@H]7CO)O[C@@H]6CO)O[C@@H]5CO)O[C@@H]4CO)O[C@@H]3CO,Train,2,5,testing
+"NZ_CCID:
+2H-1-Benzopyran-2-one, 6-(.beta.-D-glucopyranosyloxy)-7-hydroxy-",,531-75-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/62D5C330-E4AE-48CB-9FA1-DA79CCA1B5FB,,,NZ_CCID,1,C1=CC(=O)OC2=CC(=C(C=C21)O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/5281417,PubChem,O=c1ccc2cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c(O)cc2o1,Train,2,5,testing
+"EU_REACH:
+2-{[3,4-bis(prop-2-en-1-yloxy)-2,5-bis[(prop-2-en-1-yloxy)methyl]oxolan-2-yl]oxy}-3,4,5-tris(prop-2-en-1-yloxy)-6-[(prop-2-en-1-yloxy)methyl]oxane",,68784-14-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16670/7/4/2/?documentUUID=00f984a5-8664-48d8-b93f-df7540f6204a,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C=CCOCC1(C(C(C(O1)CO)O)O)OC2C(C(C(C(O2)CO)O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/21932943,PubChem,C=CCOCC1(OC2OC(CO)C(O)C(O)C2O)OC(CO)C(O)C1O,Train,2,5,testing
+"EU_REACH:
+Glucose OxidaseIUBMB  1.1.3.4",,9001-37-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23509/7/4/2/?documentUUID=c71b49b1-8e6c-4d40-8652-fb237cfca0aa,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/64689,PubChem,OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O,Train,2,5,testing
+"EU_REACH:
+trehalose",,99-20-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26864/7/4/2/?documentUUID=77f7f2d0-73f4-429d-b101-7c237782ac02,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)O)O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7427,PubChem,OC[C@H]1O[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O,Train,2,5,testing
+"EU_REACH:
+4-methyl-1,3-oxazole-5-carbonitrile",,1003-52-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30440/7/4/2/?documentUUID=a056d498-e826-41c0-8f0c-0c3878e29a29,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(OC=N1)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/70480,PubChem,Cc1ncoc1C#N,Train,3,1,testing
+"AU_HCIS:
+4-vinylcyclohexene
+
+JP_CHRIP:
+4-Vinyl-1-cyclohexene","AU_HCIS:
+Cyclohexene, 4-ethenyl-
+
+JP_CHRIP:
+4-Ethenyl-1-cyclohexene
+4-Vinyl-1-cyclohexene
+4-Vinylcyclohexene
+Cyclohexene, 4-ethenyl-
+Cyclohexenylethylene",100-40-3,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4790
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0174e.html","JP_CHRIP:
+Based on a report on rabbit skin irritation test results (ACGIH (7th, 2001)): ""moderately irritating.""",,"AU_HCIS, JP_CHRIP",2,C=CC1CCC=CC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.005C,J-GLOBAL,C=CC1CC=CCC1,Train,4,1,testing
+"NZ_CCID:
+4,6-Diamino-2-pyrimidinethiol",,1004-39-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/78382C3F-8643-49B4-A255-B9E8D312519E,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=C(NC(=S)N=C1N)N,https://pubchem.ncbi.nlm.nih.gov/compound/1201482,PubChem,Nc1cc(N)[nH]c(=S)n1,Train,5,1,testing
+"NZ_CCID:
+2H-Pyran-2-carboxaldehyde, 3,4-dihydro-","NZ_CCID:
+2-Formyl-3,4-dihydro-2H-pyran, 2-Propenal dimer, 5-Hexenal, 2,6-epoxy-",100-73-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D874B42B-FDED-4009-9E05-088A15BC210F,"NZ_CCID:
+Skin Irritation
+SPECIES: Rabbit
+RESULT: Severe
+REFERENCE SOURCE: (RTECS, 1999) [Meditext]
+Eye Irritation
+SPECIES: Human
+RESULT: Irritating
+REFERENCE SOURCE: [Meditext]",,NZ_CCID,1,C1CC(OC=C1)C=O,https://pubchem.ncbi.nlm.nih.gov/compound/60994,PubChem,O=CC1CCC=CO1,Train,6,3,testing
+"JP_CHRIP:
+3,4-Dihydro-2-methoxy-2H-pyran",,4454-05-1,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0041e.html,"JP_CHRIP:
+In a test by a 4-hour occlusive application of 0.5 mL of the undiluted test substance to the skin of six rabbits, the average scores at 24, 48, 72 hours after removal of the patch were 2.0, 2.5, 2.5 for erythema and 3.3, 2.7, 2.3 for edema (SID (2003)). Because the average scores for edema were >= 2.3 and <= 4.0 on three consecutive days, it was classified in Category 2.",,JP_CHRIP,1,COC1CCC=CO1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J24.854A,J-GLOBAL,COC1CCC=CO1,Train,6,3,testing
+"JP_CHRIP:
+2,3-epoxypropionaldehyde","JP_CHRIP:
+2,3-Epoxy-1-propanal
+Glycidaldehyde",765-34-4,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0669e.html,"JP_CHRIP:
+It was classified as Category 2 based on the statement that moderate skin irritation was observed on rabbits (HSDB (2003)).",,JP_CHRIP,1,O=CC1CO1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.323E,J-GLOBAL,O=CC1CO1,Train,6,3,testing
+"JP_CHRIP:
+1,3,5,7-Tetraazatricyclo[3.3.1.1(3,7)]decane","JP_CHRIP:
+Methenamine
+1,3,5,7-Tetraazatricyclo(3.3.1.1(3,7))decane
+1,3,5,7-Tetraazatricyclo[3.3.1.1(3,7)]decane
+Hexamethylenetetramine
+Hexamine
+Methenamine
+Urotropine",100-97-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-meti-0014e.html,"JP_CHRIP:
+There is a report that in a skin irritation test (OECD TG404) with rabbits, as a result of an occlusive application of 0.5 mL of this substance for 4 hours, no irritation was observed (EU-RAR (2008), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). On the other hand, irritant dermatitis, redness, edema, etc. were reported in occupational exposure, but reversibility etc. are unknown (EU-RAR (2008)). It is described in EU-RAR (2008) that since this substance is hydrolyzed to form formaldehyde and ammonia on contact with human skin or sweat, irritation observed in occupational exposure may be caused by the decomposition products, formaldehyde and ammonia, there is insufficient evidence to conclude that this substance is irritating (EU-RAR (2008)). From the above, it was classified as ""Not classified"" (Category 3 in UN GHS classification) based on the test compliant with the test guideline.",Provided,JP_CHRIP,1,C1N2CN3CN1CN(C2)C3,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J39.765B,J-GLOBAL,C1N2CN3CN1CN(C2)C3,Train,7,1,testing
+"JP_CHRIP:
+Triallyl cyanurate",,101-37-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0177e.html,"JP_CHRIP:
+The substance was classified as ""Not classified"" based on the document that primary skin irritation index value was 0 and resulted as non irritant in the rabbit test (OECD TG 404) (BUA 248 (2003)).",Provided,JP_CHRIP,1,C=CCOc1nc(OCC=C)nc(OCC=C)n1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J39.663J,J-GLOBAL,C=CCOc1nc(OCC=C)nc(OCC=C)n1,Train,8,1,testing
+"NZ_CCID:
+2,6-Dichloroquinone-4-chloroimide, >10% in a non hazardous diluent",,101-38-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CA4A9E17-D64B-4C23-994B-A3B707081901,"NZ_CCID:
+Skin Irritation
+R-PHRASE: R 36/ 38. [Company data]
+Eye Irritation
+R-PHRASE: R 36/ 38. [Chemwatch]",,NZ_CCID,1,C1=C(C(=O)C(=CC1=NCl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/7556,PubChem,O=C1C(Cl)=CC(=NCl)C=C1Cl,Train,9,1,testing
+"EU_REACH:
+6-bromo-2-chloro-8-cyclopentyl-5-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one",,1016636-76-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18377/7/4/2/?documentUUID=1f49a80b-df3d-4652-9c66-3dd961d723da,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(=O)N(C2=NC(=NC=C12)Cl)C3CCCC3)Br,https://pubchem.ncbi.nlm.nih.gov/compound/44248249,PubChem,Cc1c(Br)c(=O)n(C2CCCC2)c2nc(Cl)ncc12,Train,10,1,testing
+"EU_REACH:
+2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-ol",,10191-41-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11866/7/4/2/?documentUUID=54d457b2-88a6-434f-a92a-c8c95ee69e50,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C2=C(CCC(O2)(C)CCCC(C)CCCC(C)CCCC(C)C)C(=C1O)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/2116,PubChem,Cc1c(C)c2c(c(C)c1O)CCC(C)(CCCC(C)CCCC(C)CCCC(C)C)O2,Test,11,1,testing
+"NZ_CCID:
+Dimethyl-N-cyanodithioiminocarbonate",,10191-60-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D4F67168-3584-446E-BCDA-1FB53B5A71B0,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [CHEMWATCH]
+Eye Irritation
+R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CSC(=NC#N)SC,https://pubchem.ncbi.nlm.nih.gov/compound/66289,PubChem,CSC(=NC#N)SC,Train,12,1,testing
+"EU_REACH:
+(1E)-1-chloro-3,3,3-trifluoroprop-1-ene",,102687-65-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10762/7/4/2/?documentUUID=4aaceeee-98e5-4243-9227-d5fdbb852cdb,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(=C/Cl)\C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/5709018,PubChem,FC(F)(F)/C=C/Cl,Train,13,1,testing
+"EU_REACH:
+4a,6a-dimethyl-2-oxo-1H,2H,3H,4H,4aH,4bH,5H,6H,6aH,7H,8H,9H,9aH,9bH,10H-indeno[5,4-f]quinoline-7-carboxylic acid",,103335-54-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6555/7/4/2/?documentUUID=345787bf-319c-4f60-a9b3-72223d48643e,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)O)CC=C4[C@@]3(CCC(=O)N4)C,https://pubchem.ncbi.nlm.nih.gov/compound/475447,PubChem,C[C@]12CC[C@H]3[C@@H](CC=C4NC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)O,Train,14,1,testing
+"EU_REACH:
+tert-butyl 2-[(7R,9R)-9-(cyanomethyl)-6,10-dioxaspiro[4.5]decan-7-yl]acetate",,1035204-82-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10492/7/4/2/?documentUUID=f8433e56-0272-4152-91c0-c1e749bce035,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)OC(=O)C[C@H]1C[C@H](OC2(O1)CCCC2)CC#N,https://pubchem.ncbi.nlm.nih.gov/compound/44249256,PubChem,CC(C)(C)OC(=O)C[C@H]1C[C@@H](CC#N)OC2(CCCC2)O1,Train,15,2,testing
+"EU_REACH:
+tert-butyl 2-[(7R,9R)-9-{2-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]ethyl}-6,10-dioxaspiro[4.5]decan-7-yl]acetate",,1035204-85-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10263/7/4/2/?documentUUID=9ad6daf3-54e5-4d2b-9c2f-9e5df2f38f9e,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1=C(C(=C(N1CC[C@@H]2C[C@@H](OC3(O2)CCCC3)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)F)C5=CC=CC=C5)C(=O)NC6=CC=CC=C6,https://pubchem.ncbi.nlm.nih.gov/compound/44249373,PubChem,CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H]1C[C@H](CC(=O)OC(C)(C)C)OC2(CCCC2)O1,Train,15,2,testing
+"NZ_CCID:
+Trimethylsilyl N-trimethylsilylacetamidate","NZ_CCID:
+N,O-Bis(trimethylsilyl) acetamide, bis(trimethylsilyl)acetamide",10416-59-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D6D1FA8E-3CFA-4330-A3BA-CE07F6F83A57,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(=N[Si](C)(C)C)O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/25248,PubChem,CC(=N[Si](C)(C)C)O[Si](C)(C)C,Train,16,2,testing
+"NZ_CCID:
+Bis(trimethylsilyl)trifluoroacetamide",,25561-30-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E1B21EAC-BC30-45E3-8C2E-27A03FEFAC81,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C[Si](C)(C)/N=C(\C(F)(F)F)/O[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/5366669,PubChem,C[Si](C)(C)/N=C(/O[Si](C)(C)C)C(F)(F)F,Train,16,2,testing
+"NZ_CCID:
+2-Ethyl-2-oxazoline",,10431-98-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/248ACE75-3954-4A89-95E4-82B749754C01,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 35 [Company Data]
+Effects Below Cut Off
+Eye Irritation
+R PHRASE: R 35 [Company Data]",,NZ_CCID,1,CCC1=NCCO1,https://pubchem.ncbi.nlm.nih.gov/compound/66412,PubChem,CCC1=NCCO1,Train,17,1,testing
+"EU_REACH:
+(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-(1,3-benzothiazol-2-ylsulfanyl)-2-oxoethylidene]amino acetate",,104797-47-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25591/7/4/2/?documentUUID=9f7fbca7-4882-47d6-92c2-a057b97c3bd6,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)O/N=C(/C1=CSC(=N1)N)\C(=O)SC2=NC3=CC=CC=C3S2,https://pubchem.ncbi.nlm.nih.gov/compound/11417595,PubChem,CC(=O)O/N=C(\C(=O)Sc1nc2ccccc2s1)c1csc(N)n1,Train,18,2,testing
+"EU_CLP:
+2-(2-amino-1,3-thiazol-4-yl)-(Z)-2-methoxyiminoacetyl chloride hydrochloride",,119154-86-8,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CO/N=C(\C=O)/C1=CSC(=N1)N,https://pubchem.ncbi.nlm.nih.gov/compound/22395241,PubChem,CO/N=C(\C=O)c1csc(N)n1,Test,18,2,testing
+"NZ_CCID:
+1,3,5-Triisopropylhexahydro-1,3,5-triazine",,10556-98-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/49E75050-BC8A-4F9E-A6C8-AEA6E3FDFF14,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC(C)N1CN(CN(C1)C(C)C)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/25374,PubChem,CC(C)N1CN(C(C)C)CN(C(C)C)C1,Train,19,1,testing
+"JP_CHRIP:
+p-benzoquinone; p-Quinone
+
+KR_NCIS:
+1,4-benzoquinone
+
+NZ_CCID:
+1,4-Benzoquinone","JP_CHRIP:
+1,4-Benzoquinone
+2,5-Cyclohexadiene-1,4-dione
+p-Quinone
+para-Quinone
+Quinone
+
+KR_NCIS:
+2,5-Cyclohexadiene-1,4-dione
+
+NZ_CCID:
+1,4-Cyclohexadienedione, 2,5-Cyclohexadiene-1,4-dione, Benzoquinone, Chinone, Steara pbq, p-Benzoquinone, p-Quinone, para-Benzoquinone",106-51-4,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2016e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/052971B1-7514-47AC-B287-CFC0BA09CAB4","JP_CHRIP:
+[Rationale for the Classification]
+Based on (1)-(3), it was classified in Category 2.
+
+[Evidence Data]
+(1) Local cutaneous discoloration, severe irritation, erythema, swelling, and the formation of papules and vesicles were caused by exposure to this substance (ACGIH (7th, 2001), HSDB (Access on June 2019)).
+(2) Contact with this substance (solid) produces severe irritation (HSDB (Access on June 2019)).
+(3) In an in vitro skin corrosion test with the artificial skin model (EpiDerm) in accordance with OECD TG 431, the survival rates after 3 and 60 minute-exposure were 37% and 76.3%, respectively (REACH registration dossier (Access on July 2019)).
+
+[Reference Data, etc.]
+(4) It was classified in ""Skin Irrit. 2 (H315)"" in the EU-CLP classification (EU CLP classification (Access on July 2019)).
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,O=C1C=CC(=O)C=C1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.052K,J-GLOBAL,O=C1C=CC(=O)C=C1,Train,20,4,testing
+"AU_HCIS:
+maleic anhydride
+
+JP_CHRIP:
+Maleic anhydride
+
+NZ_CCID:
+Maleic anhydride
+
+US_HSDB:
+MALEIC ANHYDRIDE","AU_HCIS:
+2,5-Furandione
+
+JP_CHRIP:
+2,5-Furandione
+cis-Butenedioic anhydride
+Dihydro-2,5-dioxofuran
+Maleic acid anhydride
+Maleic anhydride
+
+NZ_CCID:
+2,5-Furandione, Dihydro-2,5-dioxofuran, Maleic acid anhydride, Toxilic anhydride, cis-Butenedioic anhydride",108-31-6,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=2795
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-2026e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9FAACCC4-8E62-4C8D-A7E6-A40199911812
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/183","JP_CHRIP:
+It is described in DFGOT vol. 4 (1992) that the application of the powder moistened with water caused necrosis in a skin irritation test with rabbits, although it is not a result of a 4-hour application. And it is described in SIDS (2007) that there was severe irritation in a skin irritation test with rabbits by a 4-hour application. Furthermore, this substance is classified in ""C; R34"" in EU DSD classification and ""Skin Corr. 1B H314"" in EU CLP classification. SIDS (2007), EU DSD classification, and EU CLP classification were obtained in this investigation and added. The classification was changed to Category 1 because the information on sub-categorization could not be obtained (the information that irritation in a Draize test with rabbits or human findings is mild and disappear within seven days).
+
+NZ_CCID:
+Skin Irritation
+R-PHRASE: R 34. [ECB]/ N-Class
+Eye Irritation
+R-PHRASE: R 34. [ECB]/ N-Class",,"AU_HCIS, JP_CHRIP, NZ_CCID, US_HSDB",4,O=C1OC(=O)C=C1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.419H,J-GLOBAL,O=C1C=CC(=O)O1,Train,20,4,testing
+"US_HSDB:
+2(5H)-Furanone",,497-23-4,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8151,,,US_HSDB,1,C1C=CC(=O)O1,https://pubchem.ncbi.nlm.nih.gov/compound/10341,PubChem,O=C1C=CCO1,Train,20,4,testing
+"NZ_CCID:
+Methyl-p-benzoquinone","NZ_CCID:
+methyl-1,4-benzoquinone",553-97-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1281E931-8643-4717-9F43-2BBC1AB69B36,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=CC(=O)C=CC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/11122,PubChem,CC1=CC(=O)C=CC1=O,Train,20,4,testing
+"NZ_CCID:
+2,5-Pyrrolidinedione, 3-dodecyl-1-(1,2,2,6,6-pentamethyl-4-piperidinyl)-",,106917-30-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DAEDE003-0744-42F3-90BA-2DEA8747D602,"NZ_CCID:
+Skin Irritation
+SPECIES:
+RESULT: The material may cause
+Skin Irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of vesicles, scaling and thickening of the skin.
+REFERENCE SOURCE: [CHEMWATCH]
+REMARK: UN 2922 class 8 PG III
+Eye Irritation
+SPECIES:
+RESULT: The material may be irritating to the eye, with prolonged contact causing inflammation. Repeated or prolonged exposure to irritants may produce
+conjunctivitis.
+REFERENCE SOURCE: [CHEMWATCH]
+R-PHRASE: R 35 Causes severe burns.
+[ECB - Annex 1]",,NZ_CCID,1,CCCCCCCCCCCCC1CC(=O)N(C1=O)C2CC(N(C(C2)(C)C)C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/86098,PubChem,CCCCCCCCCCCCC1CC(=O)N(C2CC(C)(C)N(C)C(C)(C)C2)C1=O,Train,21,3,testing
+"NZ_CCID:
+Piperidine, 1-acetyl-4-(3-dodecyl-2,5-dioxo-1-pyrrolidinyl)-2,2,6,6-tetramethyl-",,106917-31-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3E5DFD7A-7EF8-445D-9C6B-1123419FB72D,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [CHEMWATCH]
+Eye Irritation
+R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,CCCCCCCCCCCCC1CC(=O)N(C1=O)C2CC(N(C(C2)(C)C)C(=O)C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/3034263,PubChem,CCCCCCCCCCCCC1CC(=O)N(C2CC(C)(C)N(C(C)=O)C(C)(C)C2)C1=O,Train,21,3,testing
+"KR_NCIS:
+3-Dodecyl-1-(2,2,6,6-tetramethyl-4-piperidinyl)-2,5-pyrrolidinedione","KR_NCIS:
+2,5-Pyrrolidinedione, 3-dodecyl-1-(2,2,6,6-tetramethyl-4-piperidinyl)-; 2-Dodecyl-N-(2,2,6,6-tetramethyl-4-piperidinyl)succinimide; 3-Dodecy-1-(2,2,6,6-tetramethyl-4-piperidinyl)-2,5-pyrrolidinedione; 3-Dodecyl-1-(2,2,6,6-tetramethyl-4-piperidinyl)-2,5-pyrrolidinedione; 3-Dodecyl-1-(2,2,6,6-tetramethylpiperidin-4-yl)pyrrolidine-2,5-dione; 3-Dodecyl-N-(2,2,6,6-tetramethyl-4-piperidinyl)succinimide; N-(2,2,6,6-Tetramethyl-4-piperidyl)-n-dodecylsuccinimide; SUCCINIMIDE, DODECYL-N-(2,2,6,6-TETRAMETHYL-4-PIPERIDINYL)-",79720-19-7,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCCCCCCCCCCCC1CC(=O)N(C1=O)C2CC(NC(C2)(C)C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/174179,PubChem,CCCCCCCCCCCCC1CC(=O)N(C2CC(C)(C)NC(C)(C)C2)C1=O,Train,21,3,testing
+"EU_REACH:
+4-({6-chloro-2-[(4-cyanophenyl)amino]pyrimidin-4-yl}oxy)-3,5-dimethylbenzonitrile",,1070377-34-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25836/7/4/2/?documentUUID=a53cfa2c-052b-454b-b56b-9105893c8cf7,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=CC(=C1OC2=CC(=NC(=N2)NC3=CC=C(C=C3)C#N)Cl)C)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/50914946,PubChem,Cc1cc(C#N)cc(C)c1Oc1cc(Cl)nc(Nc2ccc(C#N)cc2)n1,Train,22,1,testing
+"JP_CHRIP:
+Acrylonitrile
+
+KR_NCIS:
+Acrylonitrile
+
+NZ_CCID:
+2-Propenenitrile
+
+US_HSDB:
+Acrylonitrile","JP_CHRIP:
+Acrylonitrile
+2-Propenenitrile
+Cyanoethylene
+Prop-2-enenitrile
+Vinyl cyanide
+
+KR_NCIS:
+2-Propenenitrile; Cyanoethylene
+
+NZ_CCID:
+Acrylon, Acrylonitrile, Carbacryl, Cyanoethene, Cyanoethylene, Vinyl cyanide",107-13-1,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0069e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E9E3B64B-0253-41A8-A7F9-9123718737CE
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/176","JP_CHRIP:
+It is reported that in a skin irritation test using rabbits, erythema and edema were observed after 24-hour application of 0.5 mL this substance, and a skin irritation score was 3.6 (maximum 4) (EU-RAR (2004); Initial Risk Assessment, NITE (2005)). Moreover, also in humans, multiple cases of skin irritation by acute exposure were reported (CICAD 39 (2002)). From the above, the substance was classified in Category 2. Besides, it is classified in ""Skin. Irrit. 2 H315"" in EU CLP classification (ECHA CL Inventory (Access on September 2015)).
+
+NZ_CCID:
+Skin Irritation
+SPECIES: Rabbit
+RESULT: Severe
+REFERENCE SOURCE: Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- (1,114,1990). [RTECS]
+Eye Irritation
+SPECIES: Rabbit
+RESULT: Moderate
+REFERENCE SOURCE: Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- (1,114,1990). [RTECS]",,"JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",4,C=CC#N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.055J,J-GLOBAL,C=CC#N,Train,23,1,testing
+"EU_REACH:
+1,4-Dimethyl-1H-pyrazole",,1072-68-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18375/7/4/2/?documentUUID=7d543a91-d584-47a8-88a8-6e634e26088b,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CN(N=C1)C,https://pubchem.ncbi.nlm.nih.gov/compound/136836,PubChem,Cc1cnn(C)c1,Train,24,1,testing
+"EU_REACH:
+N-[11-(dichloromethylidene)tricyclo[6.2.1.0²,⁷]undeca-2,4,6-trien-3-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide",,1072957-71-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11028/7/4/2/?documentUUID=f69725da-1cdd-4631-94dc-4e5bb7b31798,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN1C=C(C(=N1)C(F)F)C(=O)NC2=CC=CC3=C2C4CCC3C4=C(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/53491464,PubChem,Cn1cc(C(=O)Nc2cccc3c2C2CCC3C2=C(Cl)Cl)c(C(F)F)n1,Test,25,4,testing
+"EU_REACH:
+3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid",,176969-34-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12337/7/4/2/?documentUUID=9ab01da2-b5d5-42aa-b51e-a3570844b822,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN1C=C(C(=N1)C(F)F)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/18983008,PubChem,Cn1cc(C(=O)O)c(C(F)F)n1,Train,25,4,testing
+"JP_CHRIP:
+1-Methyl-N-[2-(4-methylpentan-2-yl)-3-thienyl]-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide; Penthiopyrad",,183675-82-3,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0080e.html,"JP_CHRIP:
+[Rationale for the Classification]
+It was classified as ""Not classified"" from (1).
+
+[Evidence Data]
+(1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, occlusive, 4-hour application, 72-hour observation), no irritation changes were seen in any animal (erythema/eschar score: 0/0/0, edema score: 0/0/0) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2019), ECHA RAC Opinion (2015), CLH Report (2015), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2013)).",Provided,JP_CHRIP,1,CC(C)CC(C)c1sccc1NC(=O)c1cn(C)nc1C(F)(F)F,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.036.571D,J-GLOBAL,CC(C)CC(C)c1sccc1NC(=O)c1cn(C)nc1C(F)(F)F,Train,25,4,testing
+"EU_REACH:
+632-619-2",,881685-58-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33201/7/4/2/?documentUUID=5521856f-cc44-4006-8983-8344e04bca4d,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1C2CCC1C3=C2C=CC=C3NC(=O)C4=CN(N=C4C(F)F)C,https://pubchem.ncbi.nlm.nih.gov/compound/25271089,PubChem,CC(C)C1C2CCC1c1c(NC(=O)c3cn(C)nc3C(F)F)cccc12,Train,25,4,testing
+"EU_REACH:
+bis(propan-2-yl)amine
+
+JP_CHRIP:
+Diisopropylamine
+
+NZ_CCID:
+2-Propanamine, N-(1-methylethyl)-","JP_CHRIP:
+Diisopropylamine
+DIPA
+N-(1-methylethyl)-2-propanamine
+
+NZ_CCID:
+Diisopropylamine, n-(1-Methylethyl)-2-propanamine",108-18-9,Cat 1,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13145/7/4/2/?documentUUID=a6ad48e3-cf29-472e-b939-e9846a21f2ca
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2118e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E0E0E3EE-5825-41B8-BEC5-AE9A27E04CEA","EU_REACH:
+Experimental study (OECD TG 404, GLP)
+
+JP_CHRIP:
+In a skin irritation test with rabbits (OECD TG 404 compliant), clear evidence of necrosis (discoloration to reddish brown and greenish brown at the application site) was observed within 24 hours after the 3-minute application of this substance. This was followed by drying and roughening, resulting in desquamation and open wounds, and becoming scarred. There is a description that the skin tissue showed irreversible damage in all its layers (ECHA registration information (Access on December 2017)). In addition, there is a description that alkylamines including this substance cause strong skin irritation and corrosivity (SIAP (2013)) and a description that the pH of this substance was 12.5 (HSDB (Access on August 2017)). Therefore, it was classified in Category 1A. Besides, in EU CLP classification, this substance is classified as ""Skin Corr. 1B, H314"" (ECHA CL Inventory (Access on August 2017)).
+
+NZ_CCID:
+Skin Irritation
+R-PHRASE: R 34 Causes burns. [IUCLID 2000]
+Eye Irritation
+SPECIES: Rabbit
+RESULT: Highly corrosive
+REFERENCE SOURCE: Atochem Paris la Defense
+(22) AMA-Arch-Ind-Hyg-Occup-med, vol 10, pg 61, (AMIHBC). [IUCLID 2000]
+REMARK: EC Classification: Risk of serious damage to eyes.",Provided,"EU_REACH, JP_CHRIP, NZ_CCID",3,CC(C)NC(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.496F,J-GLOBAL,CC(C)NC(C)C,Train,26,1,testing
+"JP_CHRIP:
+Isopropyl ether","JP_CHRIP:
+2,2'-Oxybispropane
+2-Isopropoxypropane
+diisopropyl ether
+Isopropyl ether",108-20-3,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2020e.html,"JP_CHRIP:
+[Rationale for the Classification]
+Based on (1), it was classified as ""Not classified.""
+
+[Evidence Data]
+(1) In a ski irritation test in which 0.5 mL of this substance was applied semiocclusively to the skin of rabbits for 4 hours in accordance with OECD TG 404, the mean scores at 24/48/72 hours for erythema and edema were 1.77 and 0.87, respectively (REACH registration dossier (Access on July 2019)).
+
+[Reference Data, etc.]
+(2) This substance had a slight irritative effect on the skin and caused irritation to the eyes of rabbits (DFGOT vol.21 (2005)).",Provided,JP_CHRIP,1,CC(C)OC(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.069E,J-GLOBAL,CC(C)OC(C)C,Train,27,1,testing
+"EU_REACH:
+tert-butyl (2S)-2-[5-(4'-{2-[(2S)-1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl]-1H-imidazol-5-yl}-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylate",,1085706-46-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6021/7/4/2/?documentUUID=629fb0da-1cd8-4863-a858-26f103bc9944,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)OC(=O)N1CCC[C@H]1C2=CC(=NN2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C(=O)OC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/59345130,PubChem,CC(C)(C)OC(=O)N1CCC[C@H]1c1cc(-c2ccc(-c3ccc(-c4cnc([C@@H]5CCCN5C(=O)OC(C)(C)C)[nH]4)cc3)cc2)n[nH]1,Train,28,1,testing
+"EU_REACH:
+2,4,6,8-tetramethyl-1,3,5,7-tetraoxocane
+
+JP_CHRIP:
+2,4,6,8-Tetramethyl-1,3,5,7-tetraoxacyclooctane","JP_CHRIP:
+2,4,6,8-tetramethyl-1,3,5,7-tetraoxacyclooctane (synonym:metaldehyde)
+metaldehyde",108-62-3,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24890/7/4/2/?documentUUID=76e6ec4f-e828-4812-a5d5-db97444d7c48
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0185e.html","EU_REACH:
+Experimental study (OECD TG 404, GLP)
+
+JP_CHRIP:
+Based on a report of ""not irritant"" in a rabbit test (EPA RED (2006), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2009)).",Provided,"EU_REACH, JP_CHRIP",2,CC1OC(C)OC(C)OC(C)O1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.423F,J-GLOBAL,CC1OC(C)OC(C)OC(C)O1,Train,29,2,testing
+"JP_CHRIP:
+2,4,6-trimethyl-1,3,5-trioxan; paraldehyde","JP_CHRIP:
+p-Acetaldehyde
+p-acetaldehydo
+Paracetaldehyde",123-63-7,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0185e.html,"JP_CHRIP:
+Rabbit tests found the substance moderately irritating (RTECS (2006)), and its solution is reported to be irritating to the skin and eyes (HSDB (1986)). Thus, the substance was classified into Category 2.",,JP_CHRIP,1,CC1OC(C)OC(C)O1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.543C,J-GLOBAL,CC1OC(C)OC(C)O1,Train,29,2,testing
+"AU_HCIS:
+furan
+
+NZ_CCID:
+Furan","NZ_CCID:
+Divinylene oxide, Furfuran, Oxacyclopentadiene, Oxole, Tetrole",110-00-9,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=2206
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0D705B96-A32C-4BCD-9F4D-A6FA708DD0C5","NZ_CCID:
+Skin Irritation
+SPECIES: Guinea pig
+RESULT: When applied in 1-50% solutions to guinea pig skin furan was irritating and allergenic.
+REFERENCE SOURCE: [Peer Reviewed] [CHERNOUSOV AD; GIG SANIT 6: 28-32 (1974)] [HSDB]
+Eye Irritation
+SPECIES: Human
+RESULT: Burns to the eyes may occur from direct contact
+REFERENCE SOURCE: (EPA, 1985; Sittig, 1991). [Meditext]",,"AU_HCIS, NZ_CCID",2,C1=COC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/8029,PubChem,c1ccoc1,Train,30,1,testing
+"NZ_CCID:
+Thiophene, tetrahydro-","NZ_CCID:
+Tetrahydrothiophene",110-01-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/760AD40A-79A9-4DA5-B8CB-DF3747157EF4,"NZ_CCID:
+Skin Irritation
+SPECIES: Rabbit
+RESULT: Severely irritating.
+REFERENCE SOURCE: (Tetrahydrothiophen: Anonymous : TA:Toxikologische Bewertung. Heidelberg, Berufsgenossenschaft der chemischen Industrie PG:13 p YR:1993 IP: VI:29 [TOXLINE]
+Eye Irritation
+SPECIES: Rabbit
+RESULT: Moderately irritating.
+REFERENCE SOURCE: (Tetrahydrothiophen: Anonymous : TA:Toxikologische Bewertung. Heidelberg, Berufsgenossenschaft der chemischen Industrie PG:13 p YR:1993 IP: VI:29) [TOXLINE]",,NZ_CCID,1,C1CCSC1,https://pubchem.ncbi.nlm.nih.gov/compound/1127,PubChem,C1CCSC1,Train,31,1,testing
+"JP_CHRIP:
+Thiophene","JP_CHRIP:
+Divinylene sulphide
+Thiacyclopentadiene
+Thiofuran",110-02-1,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0069e.html,"JP_CHRIP:
+Based on a report that in man, tiophene has caused skin irritation (HSDB (2003)), the substance was classified into Category 2.",,JP_CHRIP,1,c1ccsc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.445G,J-GLOBAL,c1ccsc1,Train,32,1,testing
+"EU_REACH:
+2,6-difluoro-3-(propane-1-sulfonamido)benzoic acid",,1103234-56-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8013/7/4/2/?documentUUID=8cf76091-2c73-4919-b6a9-59a7249d0760,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)O)F,https://pubchem.ncbi.nlm.nih.gov/compound/46192923,PubChem,CCCS(=O)(=O)Nc1ccc(F)c(C(=O)O)c1F,Train,33,4,testing
+"EU_REACH:
+N-{3-[5-(4-chlorophenyl)-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide",,1262985-23-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32275/7/4/2/?documentUUID=c723d5cf-b0d8-4fae-800a-e52bf23c7403,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CN(C3=C2C=C(C=N3)C4=CC=C(C=C4)Cl)C(=O)C5=C(C=CC=C5Cl)Cl)F,https://pubchem.ncbi.nlm.nih.gov/compound/51001026,PubChem,CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2cn(C(=O)c3c(Cl)cccc3Cl)c3ncc(-c4ccc(Cl)cc4)cc23)c1F,Train,33,4,testing
+"EU_REACH:
+N-{3-[5-bromo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide",,1262985-24-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31758/7/4/2/?documentUUID=ca052caf-297a-4bb5-b3b6-1e1e62c00944,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CN(C3=C2C=C(C=N3)Br)C(=O)C4=C(C=CC=C4Cl)Cl)F,https://pubchem.ncbi.nlm.nih.gov/compound/51001025,PubChem,CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2cn(C(=O)c3c(Cl)cccc3Cl)c3ncc(Br)cc23)c1F,Train,33,4,testing
+"EU_REACH:
+N-(3-{5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide",,918504-27-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31792/7/4/2/?documentUUID=4b696952-d29c-40b1-bd40-1a67d4ce1795,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)Br)F,https://pubchem.ncbi.nlm.nih.gov/compound/11984556,PubChem,CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(Br)cc23)c1F,Train,33,4,testing
+"KR_NCIS:
+Tris(2,3,4,5,6-pentafluorophenyl)borane",,1109-15-5,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,B(C1=C(C(=C(C(=C1F)F)F)F)F)(C2=C(C(=C(C(=C2F)F)F)F)F)C3=C(C(=C(C(=C3F)F)F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/582056,PubChem,Fc1c(F)c(F)c(B(c2c(F)c(F)c(F)c(F)c2F)c2c(F)c(F)c(F)c(F)c2F)c(F)c1F,Train,34,1,testing
+"AU_HCIS:
+1,3-propanesultone
+
+JP_CHRIP:
+1,2-Oxathiolane 2,2-dioxide; 1,3-Propane sultone
+
+KR_NCIS:
+1,2-Oxathiolane, 2,2-dioxide","AU_HCIS:
+1,2-oxathiolane 2,2-dioxide
+
+JP_CHRIP:
+1,2-oxathiolane 2,2- dioxide
+1,2-Oxathiolane 2,2-dioxide
+1,2-Oxathiolane, 2,2-dioxide
+1,2-Oxathiolane-2,2-dioxide
+1,3-Propane sultone
+1,3-Propanesultone
+1-Propanesulfonic acid, 3-hydroxy-gamma-sultone
+3-Hydroxy-1-propanesulphonic acid sultone
+Plopane-1,3-sultone
+propane-1,3-sultone
+
+KR_NCIS:
+1,3-Propanesultone",1120-71-4,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3663
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2085e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP:
+[Rationale for the Classification]
+It was classified in Category 2 from (1), (2). The classification result was changed because new data (1), (2) were obtained.
+
+[Evidence Data]
+(1) This substance was reported to be irritating to the skin in both humans and animals (MAK (DFG) vol.4 (1992)).
+(2) In an in-vitro skin corrosion test according to OECD TG 431 (in vitro membrane barrier test), it was judged as not corrosive (REACH registration dossier (Access on August 2020)).
+
+[Reference Data, etc.]
+(3) This substance was reported to be slightly irritating in a skin irritation test with rabbits (Draize test) (Risk Assessment Report (Ministry of Health, Labour and Welfare, 2010)).
+(4) In an experiment in which this substance (0.1-20 mL or 10 drops) was applied to the skin of guinea pigs, moderate edema and necrosis over the entire patch and erythema (score = 3) at the perimeter of the patch were observed, and alopecia and scarring were seen two weeks later. In an experiment by open application of this substance (10 drops), erythema (score = 2-3) and edema were found at 24 and 48 hours post application, but the effects were minimal after one to two weeks (AICIS (formerly, NICNAS) IMAP (2015), REACH registration dossier (Access on August 2020)).",,"AU_HCIS, JP_CHRIP, KR_NCIS",3,O=S1(=O)CCCO1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.528D,J-GLOBAL,O=S1(=O)CCCO1,Train,35,2,testing
+"NZ_CCID:
+1,4-Butanesultone",,1633-83-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4E16B1D1-9C2E-4343-B0A4-93DDA2213F1F,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1CCS(=O)(=O)OC1,https://pubchem.ncbi.nlm.nih.gov/compound/15411,PubChem,O=S1(=O)CCCCO1,Train,35,2,testing
+"KR_NCIS:
+Omadine","KR_NCIS:
+1-Hydroxypyridine-2-thione; 2-Mercaptopyridine 1-oxide; 2-Mercaptopyridine monoxide; 2-Mercaptopyridine-N-oxide; 2-Pyridinethiol 1-oxide; 2-Pyridinethiol N-oxide; pyridine-2-thiol N-oxide",1121-31-9,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C1=CC(=S)N(C=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/1570,PubChem,On1ccccc1=S,Train,36,2,testing
+"EU_REACH:
+1-hydroxy-1,2-dihydropyridin-2-one",,822-89-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26617/7/4/2/?documentUUID=a85f74e3-7b99-4640-ba82-ccadce8bd02b,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=O)N(C=C1)O,https://pubchem.ncbi.nlm.nih.gov/compound/69975,PubChem,O=c1ccccn1O,Train,36,2,testing
+"EU_REACH:
+2,6,6-trimethylcyclohex-2-ene-1,4-dione",,1125-21-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6062/7/4/2/?documentUUID=25e23680-51ca-4220-b652-161f64b27635,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=O)CC(C1=O)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/62374,PubChem,CC1=CC(=O)CC(C)(C)C1=O,Train,37,1,testing
+"NZ_CCID:
+1-Phenylpyrazole",,1126-00-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/989FA2ED-1E05-4B36-A422-F76B4C893AE0,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CC=C(C=C1)N2C=CC=N2,https://pubchem.ncbi.nlm.nih.gov/compound/70769,PubChem,c1ccc(-n2cccn2)cc1,Train,38,1,testing
+"EU_CLP:
+1,1-diisopropoxycyclohexane",,1132-95-2,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C)OC1(CCCCC1)OC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11745673,PubChem,CC(C)OC1(OC(C)C)CCCCC1,Test,39,1,testing
+"EU_CLP:
+3-(2-bromopropionoyl)-4,4-dimethyl-1,3-oxazolan-2-one",,114341-88-7,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C(=O)N1C(=O)OCC1(C)C)Br,https://pubchem.ncbi.nlm.nih.gov/compound/9856314,PubChem,CC(Br)C(=O)N1C(=O)OCC1(C)C,Test,40,1,testing
+"NZ_CCID:
+Tribromoacetaldehyde","NZ_CCID:
+Bromal",115-17-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FC7AC182-A3F5-48B4-A4DA-47EBD00497E9,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [CHEMWATCH]
+Eye Irritation
+R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C(=O)C(Br)(Br)Br,https://pubchem.ncbi.nlm.nih.gov/compound/8256,PubChem,O=CC(Br)(Br)Br,Train,41,1,testing
+"EU_CLP:
+1,4,5,6,7,7-hexachlorobicyclo [2,2,1]hept-5-ene-2,3-dicarboxylic anhydride chlorendic anhydride",,115-27-5,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C12C(C(=O)OC1=O)C3(C(=C(C2(C3(Cl)Cl)Cl)Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/8265,PubChem,O=C1OC(=O)C2C1C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl,Test,42,2,testing
+"JP_CHRIP:
+Bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid, 1,4,5,6,7,7-hexachloro-","JP_CHRIP:
+1,4,5,6,7,7-Hexachlorobicyclo[2.2.1]-5-heptene-2,3-dicarboxylic acid
+1,4,5,6,7,7-Hexachlorobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid
+Chlorendic acid",115-28-6,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0185e.html,"JP_CHRIP:
+It was classified as Category 2 from description that the moderate irritation was observed in the application test on rabbit skin in CERI Hazard Data (2002).",,JP_CHRIP,1,OC(=O)C1C(C(=O)O)C2(Cl)C(=C(Cl)C1(Cl)C2(Cl)Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J40.560D,J-GLOBAL,O=C(O)C1C(C(=O)O)C2(Cl)C(Cl)=C(Cl)C1(Cl)C2(Cl)Cl,Train,42,2,testing
+"EU_CLP:
+spiroxamine (ISO); 8-tert-butyl-1,4-dioxaspiro[4.5]decan-2-ylmethyl(ethyl)(propyl)amine",,118134-30-8,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCCN(CC)CC1COC2(O1)CCC(CC2)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/86160,PubChem,CCCN(CC)CC1COC2(CCC(C(C)(C)C)CC2)O1,Test,43,2,testing
+"EU_REACH:
+8-tert-butyl-2-(chloromethyl)-1,4-dioxaspiro[4.5]decane",,118135-28-7,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1540/7/4/2/?documentUUID=40544a7b-bf0e-43db-b1ec-ba12d7a66d1c,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1CCC2(CC1)OCC(O2)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/14326294,PubChem,CC(C)(C)C1CCC2(CC1)OCC(CCl)O2,Test,43,2,testing
+"EU_REACH:
+3-[(3R)-3-amino-2,3,4,9-tetrahydro-1H-carbazol-9-yl]propanoic acid",,1182722-58-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12204/7/4/2/?documentUUID=ce3e9b8c-c03f-4805-8ac7-cdc05d5bf9eb,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC2=C(C[C@@H]1N)C3=CC=CC=C3N2CCC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/46928273,PubChem,N[C@@H]1CCc2c(c3ccccc3n2CCC(=O)O)C1,Train,44,2,testing
+"EU_REACH:
+ethyl 3-[(3R)-3-{[(1S)-1-phenylethyl]amino}-2,3,4,9-tetrahydro-1H-carbazol-9-yl]propanoate",,1638586-33-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17128/7/4/2/?documentUUID=545a8033-73e7-481d-b5af-53d1c3534088,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CCN1C2=C(C[C@@H](CC2)N[C@@H](C)C3=CC=CC=C3)C4=CC=CC=C41,https://pubchem.ncbi.nlm.nih.gov/compound/154734788,PubChem,CCOC(=O)CCn1c2c(c3ccccc31)C[C@H](N[C@@H](C)c1ccccc1)CC2,Train,44,2,testing
+"EU_CLP:
+transfluthrin (ISO); 2,3,5,6-tetrafluorobenzyl trans-2-(2,2-dichlorovinyl)-3,3-dimethylcyclopropanecarboxylate",,118712-89-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC1([C@@H]([C@H]1C(=O)OCC2=C(C(=CC(=C2F)F)F)F)C=C(Cl)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/656612,PubChem,CC1(C)[C@H](C=C(Cl)Cl)[C@H]1C(=O)OCc1c(F)c(F)cc(F)c1F,Test,45,1,testing
+"US_HSDB:
+Maltol",,118-71-8,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8320,,,US_HSDB,1,CC1=C(C(=O)C=CO1)O,https://pubchem.ncbi.nlm.nih.gov/compound/8369,PubChem,Cc1occc(=O)c1O,Train,46,2,testing
+"US_HSDB:
+Deferiprone",,30652-11-0,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8335,,,US_HSDB,1,CC1=C(C(=O)C=CN1C)O,https://pubchem.ncbi.nlm.nih.gov/compound/2972,PubChem,Cc1c(O)c(=O)ccn1C,Train,46,2,testing
+"EU_REACH:
+(1S,2S,4R,6S,8S,11R,12S,14S,15R,16S)-2,16-dimethyl-14-(pyrrolidin-1-yl)-5-oxapentacyclo[9.7.0.0²,⁸.0⁴,⁶.0¹²,¹⁶]octadecan-15-ol",,119302-19-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7297/7/4/2/?documentUUID=b8bce7e8-1efd-4a37-9adf-60ea68834fe5,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@]12CC[C@H]3[C@H]([C@@H]1C[C@@H]([C@@H]2O)N4CCCC4)CC[C@@H]5[C@@]3(C[C@@H]6[C@H](C5)O6)C,https://pubchem.ncbi.nlm.nih.gov/compound/16063872,PubChem,C[C@]12C[C@H]3O[C@H]3C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](O)[C@@H](N3CCCC3)C[C@@H]12,Test,47,4,testing
+"EU_REACH:
+(3aS,3bR,9aS,9bR,11aS)-9a,11a-dimethyl-8-(morpholin-4-yl)-2-(pyrrolidin-1-yl)-hexadecahydro-1H-cyclopenta[a]phenanthrene-1,7-diol",,119302-20-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7282/7/4/2/?documentUUID=b5120f69-1dfa-4c1c-99c5-7c47137ba9ff,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@]12CC[C@H]3[C@H]([C@@H]1C[C@@H]([C@@H]2O)N4CCCC4)CC[C@@H]5[C@@]3(C[C@@H]([C@H](C5)O)N6CCOCC6)C,https://pubchem.ncbi.nlm.nih.gov/compound/16063873,PubChem,C[C@]12C[C@H](N3CCOCC3)[C@@H](O)C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)[C@@H](O)[C@@H](N3CCCC3)C[C@@H]12,Train,47,4,testing
+"EU_REACH:
+Androstan-3,17-diol,2-(4-morpholinyl)-16-(1-pyrrolidinyl)-, 17-acetate (2α,3α,5α,16α,17β)-",,119302-24-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7706/7/4/2/?documentUUID=885293ad-c1ee-4e43-84d9-69ac9eda760f,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)O[C@H]1[C@H](C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(C[C@@H]([C@H](C4)O)N5CCOCC5)C)C)N6CCCC6,https://pubchem.ncbi.nlm.nih.gov/compound/16064933,PubChem,CC(=O)O[C@H]1[C@@H](N2CCCC2)C[C@H]2[C@@H]3CC[C@H]4C[C@H](O)[C@@H](N5CCOCC5)C[C@]4(C)[C@H]3CC[C@@]21C,Test,47,4,testing
+"EU_REACH:
+(1S,2S,4R,6S,8S,11R,12S,14S,16S)-2,16-dimethyl-14-(pyrrolidin-1-yl)-5-oxapentacyclo[9.7.0.0²,⁸.0⁴,⁶.0¹²,¹⁶]octadecan-15-one",,159325-45-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7280/7/4/2/?documentUUID=8beba8d8-85bf-4c36-8e04-582ea6c9baa7,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@]12CC[C@H]3[C@H]([C@@H]1C[C@@H](C2=O)N4CCCC4)CC[C@@H]5[C@@]3(C[C@@H]6[C@H](C5)O6)C,https://pubchem.ncbi.nlm.nih.gov/compound/16063837,PubChem,C[C@]12C[C@H]3O[C@H]3C[C@@H]1CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)[C@@H](N3CCCC3)C[C@@H]12,Test,47,4,testing
+"EU_REACH:
+2-benzyl-2-(dimethylamino)-1-[4-(morpholin-4-yl)phenyl]butan-1-one
+
+JP_CHRIP:
+2-Benzyl-2-(N,N-dimethylamino)-1-(4-morpholinophenyl)butan-1-one",,119313-12-1,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1145/7/4/2/?documentUUID=c308d4e8-3e9a-41c1-a00b-bb2f082bb774
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-0002e.html","EU_REACH:
+Experimental study (OECD TG 404, GLP)
+
+JP_CHRIP:
+[Rationale for the Classification]
+It was classified as ""Not classified"" from (1), (2).
+
+[Evidence Data]
+(1) No skin reactions were observed in a skin irritation test with rabbits according to OECD TG 404 (REACH registration dossier (Access on June 2020)).
+(2) No skin reactions were seen in a skin irritation test with rabbits according to EU Method B.4 (Acute Toxicity: Dermal Irritation/Corrosion) (REACH registration dossier (Access on June 2020)).",Provided,"EU_REACH, JP_CHRIP",2,CCC(Cc1ccccc1)(N(C)C)C(=O)c1ccc(cc1)N1CCOCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J261.950D,J-GLOBAL,CCC(Cc1ccccc1)(C(=O)c1ccc(N2CCOCC2)cc1)N(C)C,Train,48,3,testing
+"EU_REACH:
+2-(dimethylamino)-2-[(4-methylphenyl)methyl]-1-[4-(morpholin-4-yl)phenyl]butan-1-one",,119344-86-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15616/7/4/2/?documentUUID=055fc99b-f8bb-4064-8461-21392930a973,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(CC1=CC=C(C=C1)C)(C(=O)C2=CC=C(C=C2)N3CCOCC3)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/22019755,PubChem,CCC(Cc1ccc(C)cc1)(C(=O)c1ccc(N2CCOCC2)cc1)N(C)C,Train,48,3,testing
+"EU_REACH:
+2-methyl-1-[4-(methylsulfanyl)phenyl]-2-(morpholin-4-yl)propan-1-one",,71868-10-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11144/7/4/2/?documentUUID=6d4327de-69b9-4730-bf18-d90b90c8bd9b,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C(=O)C1=CC=C(C=C1)SC)N2CCOCC2,https://pubchem.ncbi.nlm.nih.gov/compound/92387,PubChem,CSc1ccc(C(=O)C(C)(C)N2CCOCC2)cc1,Train,48,3,testing
+"KR_NCIS:
+4,6-Dichloropyrimidine",,1193-21-1,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C1=C(N=CN=C1Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/70943,PubChem,Clc1cc(Cl)ncn1,Train,49,2,testing
+"EU_REACH:
+4,6-Dichloro-5-fluoropyrimidine",,213265-83-9,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33824/7/4/2/?documentUUID=a59bacb8-5c03-46d9-a9d3-350b738a4d85,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=NC(=C(C(=N1)Cl)F)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11286675,PubChem,Fc1c(Cl)ncnc1Cl,Train,49,2,testing
+"EU_REACH:
+6-hydroxypyrimidin-4(3H)-one",,1193-24-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5164/7/4/2/?documentUUID=90eac021-7cb1-48d4-91f4-06f7ce519f18,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(N=CNC1=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/14512,PubChem,O=c1cc(O)nc[nH]1,Train,50,2,testing
+"EU_REACH:
+(1,4,5,6-tetrahydro-4,6-dioxopyrimidin-2-yl)cyanamide",,55067-10-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23973/7/4/2/?documentUUID=405d1b53-9bb9-4df2-916e-e9bf8e8a45df,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(N=C(NC1=O)NC#N)O,https://pubchem.ncbi.nlm.nih.gov/compound/246750,PubChem,N#CNc1nc(O)cc(=O)[nH]1,Train,50,2,testing
+"EU_REACH:
+3-(2-hydroxyethyl)-1,2,3,4-tetrahydroquinazoline-2,4-dione",,1207-75-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22543/7/4/2/?documentUUID=5578c8ff-4520-43d8-837c-8a517c19c62c,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C(=O)N(C(=O)N2)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/71016,PubChem,O=c1[nH]c2ccccc2c(=O)n1CCO,Train,51,2,testing
+"EU_REACH:
+3-(2-CHLOROETHYL)QUINAZOLINE-2,4(1H,3H)-DIONE",,5081-87-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19396/7/4/2/?documentUUID=aa38a6de-bc2e-4fe3-b056-9d7b4699f06a,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C(=O)N(C(=O)N2)CCCl,https://pubchem.ncbi.nlm.nih.gov/compound/78766,PubChem,O=c1[nH]c2ccccc2c(=O)n1CCCl,Train,51,2,testing
+"EU_REACH:
+N-methyl-1-(trans-4-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)methanesulfonamide",,1208319-26-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32698/7/4/2/?documentUUID=5ab3230a-d471-4185-914a-7821f0618c40,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CNS(=O)(=O)CC1CCC(CC1)N(C)C2=NC=NC3=C2C=CN3,https://pubchem.ncbi.nlm.nih.gov/compound/44631938,PubChem,CNS(=O)(=O)CC1CCC(N(C)c2ncnc3[nH]ccc23)CC1,Train,52,1,testing
+"JP_CHRIP:
+Trimethyl phosphite
+
+NZ_CCID:
+Phosphorous acid, trimethyl ester
+
+US_HSDB:
+TRIMETHYL PHOSPHITE","JP_CHRIP:
+Phophorous acid, trimethyl ester
+Trimethoxy phosphine
+
+NZ_CCID:
+Trimethoxyphosphine, Trimethyl phosphite",121-45-9,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2036e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9DEB9F50-4C4F-4C2C-9E34-902610F2F1FB
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1007","JP_CHRIP:
+[Rationale for the Classification]
+Based on (1), it was classified in Category 2.
+
+[Evidence Data]
+(1) This substance exhibits moderate to severe persistent irritation to the skin of rabbits (ACGIH (7th, 2001), PATTY (6th, 2012), HSDB (Access on June 2019)).
+
+NZ_CCID:
+Skin Irritation
+SPECIES: Rabbit
+RESULT: Severe
+REFERENCE SOURCE: Toxicology of Drugs and Chemicals, Deichmann, W.B., New York, Academic Press, Inc., 1969 (-,609,1969) [RTECS]
+Eye Irritation
+SPECIES:
+RESULT: Mild
+REFERENCE SOURCE: Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950- (29,393,1978) [RTECS]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,COP(OC)OC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.486D,J-GLOBAL,COP(OC)OC,Train,53,1,testing
+"EU_REACH:
+2,2-dichloro-1-[5-(furan-2-yl)-2,2-dimethyl-1,3-oxazolidin-3-yl]ethan-1-one",,121776-33-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7356/7/4/2/?documentUUID=cedd60ea-7013-42a2-ae58-6debacb290c5,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(N(CC(O1)C2=CC=CO2)C(=O)C(Cl)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/86187,PubChem,CC1(C)OC(c2ccco2)CN1C(=O)C(Cl)Cl,Train,54,1,testing
+"JP_CHRIP:
+Hexahydro-1,3,5-trinitro-1,3,5-triazine (with 15% water, by mass)","JP_CHRIP:
+1,3,5-Triaza-1,3,5-trinitrocyclohexane
+Cyclonite
+Cyclotrimethylenetrinitramine
+Hexahydro-1,3,5-trinitro-1,3,5-triazine
+Hexogen
+RDX
+RDX (Royal Demolition Explosive)",121-82-4,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2037e.html,"JP_CHRIP:
+[Rationale for the Classification]
+Based on (1), it was classified as ""Not classified."" Besides, the category was changed, since new data were obtained.
+
+[Evidence Data]
+(1) In a skin irritation test with rabbits equivalent or similar to OECD TG 404, the number of animals whose scores were 1 or above consecutively until 72 hours was only one out of six, and all of the scores for other animals were zero at 72 hours (REACH registration dossier (Access on August 2019)).
+
+[Reference Data, etc.]
+(2) There are a report that no irritation was observed in a human patch test (dose unknown) and a report that dermatitis was induced (ATSDR (2012)).
+(3) Slight erythema was induced in guinea pigs exposed to this substance (1,000 mg/kg) (ATSDR (2012)).
+(4) Dermatitis was induced in rabbits by exposure to this substance in acetone (27 mg/kg), in cyclohexane (37.5 mg/kg), or in DMSO (165 mg/kg) (ATSDR (2012)).",Provided,JP_CHRIP,1,[O-][N+](=O)N1CN(CN(C1)[N+](=O)[O-])[N+](=O)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.346E,J-GLOBAL,O=[N+]([O-])N1CN([N+](=O)[O-])CN([N+](=O)[O-])C1,Train,55,1,testing
+"NZ_CCID:
+Cyclohexanone peroxide, 30-60%, 30-60% dibutyl phthalate, 10-30% ethyl acetate","NZ_CCID:
+Cyclohexanone peroxide",12262-58-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BFC446A9-880E-4187-8708-5DF6B980A43A,"NZ_CCID:
+Skin Irritation
+R-PHRASE: R 34 Causes Burns. [N-Class]
+Eye Irritation
+SPECIES: Rabbit
+RESULT: Severe
+REFERENCE SOURCE: [Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75. (8,25,1958)] [RTECS]",,NZ_CCID,1,C1CCC(CC1)(O)OOC2(CCCCC2)OO,https://pubchem.ncbi.nlm.nih.gov/compound/6521,PubChem,OOC1(OOC2(O)CCCCC2)CCCCC1,Train,56,1,testing
+"EU_CLP:
+4-methyl-8-methylenetricyclo[3.3.1.13,7]decan-2-ol",,122760-84-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC1C2CC3CC1C(C(C2)C3=C)O,https://pubchem.ncbi.nlm.nih.gov/compound/180122,PubChem,C=C1C2CC3CC1C(O)C(C2)C3C,Test,57,2,testing
+"EU_CLP:
+4-methyl-8-methylenetricyclo[3.3.1.13,7]dec-2-yl acetate",,122760-85-4,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC1C2CC3CC1C(C(C2)C3=C)OC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/19830424,PubChem,C=C1C2CC3CC1C(OC(C)=O)C(C2)C3C,Test,57,2,testing
+"EU_REACH:
+4-(4-iodo-1H-pyrazol-1-yl)piperidine",,1229457-94-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5524/7/4/2/?documentUUID=3d776ce8-229b-4ae8-ba55-b87b733b64b1,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CNCCC1N2C=C(C=N2)I,https://pubchem.ncbi.nlm.nih.gov/compound/53256681,PubChem,Ic1cnn(C2CCNCC2)c1,Train,58,1,testing
+"EU_REACH:
+14,14',15,15'-tetradehydro-7,7'-spirobi[dibenzo[b,g][1,9,4,6]dioxadiazacyclododecine]",,1231148-36-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6054/7/4/2/?documentUUID=378da222-d36f-4739-a917-65aa83fe80d1,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C2(COC3=CC=CC=C3N=C=NC4=CC=CC=C4O1)COC5=CC=CC=C5N=C=NC6=CC=CC=C6OC2,https://pubchem.ncbi.nlm.nih.gov/compound/58434418,PubChem,C1=Nc2ccccc2OCC2(COc3ccccc3N=1)COc1ccccc1N=C=Nc1ccccc1OC2,Train,59,1,testing
+"US_HSDB:
+Isoborneol",,124-76-5,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/2843,,,US_HSDB,1,C[C@]12CC[C@@H](C1(C)C)C[C@H]2O,https://pubchem.ncbi.nlm.nih.gov/compound/10049,PubChem,CC1(C)[C@@H]2CC[C@]1(C)[C@H](O)C2,Train,60,2,testing
+"NZ_CCID:
+Isobornyl acetate","NZ_CCID:
+1,7,7-Trimethylbicyclo(2.2.1)heptan-2-yl acetate, exo-, Bicyclo(2.2.1)heptan-2-ol, 1,7,7-trimethyl-, acetate, (1R,2R,4R)-rel-, Isoborneol, acetate, Pichtosin",125-12-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/50707C25-2FE3-4DF4-B25F-7B1137087EDC,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38. [MSDS]
+Eye Irritation
+R PHRASE: R 36. [MSDS]",,NZ_CCID,1,CC(=O)O[C@H]1C[C@H]2CC[C@]1(C2(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/247573,PubChem,CC(=O)O[C@H]1C[C@H]2CC[C@@]1(C)C2(C)C,Train,60,2,testing
+"EU_REACH:
+603-101-3",,125962-78-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27195/7/4/2/?documentUUID=63114169-09d0-417b-802e-bb4aae625213,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)C2=CCC(CC2)C3CCC4(CC3)OCCO4,https://pubchem.ncbi.nlm.nih.gov/compound/91980675,PubChem,Cc1ccc(C2=CCC(C3CCC4(CC3)OCCO4)CC2)cc1,Train,61,2,testing
+"EU_REACH:
+8-[4-(3,4-difluorophenyl)cyclohex-3-en-1-yl]-1,4-dioxaspiro[4.5]decane",,147622-83-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22655/7/4/2/?documentUUID=9d9ba89e-8f2b-4f66-b70c-ee2a4bacc764,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC(=CCC1C2CCC3(CC2)OCCO3)C4=CC(=C(C=C4)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/11559061,PubChem,Fc1ccc(C2=CCC(C3CCC4(CC3)OCCO4)CC2)cc1F,Train,61,2,testing
+"NZ_CCID:
+3-Bromo-1-chloro-dimethylhydantoin","NZ_CCID:
+Hydantoin, 3-bromo-1-chloro-5,5-dimethyl-, 2,4-Imidazolidinedione, 3-bromo-1-chloro-5,5-dimethyl-",126-06-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/50941E84-54E1-443B-9E14-8276396CF98D,"NZ_CCID:
+Skin Irritation
+REMARK: Classification based on a protected data source.
+Eye Irritation
+REMARK: Classification based on a protected data source.",,NZ_CCID,1,CC1(C(=O)N(C(=O)N1Cl)Br)C,https://pubchem.ncbi.nlm.nih.gov/compound/31335,PubChem,CC1(C)C(=O)N(Br)C(=O)N1Cl,Train,62,4,testing
+"KR_NCIS:
+1-Bromo-3-chloro-5,5-dimethylhydantoin","KR_NCIS:
+1-Bromo-3-chloro-5,5-dimethylhydantoin",16079-88-2,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CC1(C(=O)N(C(=O)N1Br)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/61828,PubChem,CC1(C)C(=O)N(Cl)C(=O)N1Br,Train,62,4,testing
+"NZ_CCID:
+1,3-Dibromo-5,5-dimethylhydantoin",,77-48-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E81547F1-5A68-4290-B24C-239E70B42266,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC1(C(=O)N(C(=O)N1Br)Br)C,https://pubchem.ncbi.nlm.nih.gov/compound/6479,PubChem,CC1(C)C(=O)N(Br)C(=O)N1Br,Train,62,4,testing
+"EU_CLP:
+1,3-dichloro-5-ethyl-5-methylimidazolidine-2,4-dione",,89415-87-2,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCC1(C(=O)N(C(=O)N1Cl)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/62299,PubChem,CCC1(C)C(=O)N(Cl)C(=O)N1Cl,Test,62,4,testing
+"EU_REACH:
+1-(pyrimidin-5-ylmethyl)-3-[3-(trifluoromethyl)phenyl]pyrido[1,2-a]pyrimidin-1-ium-3-ide-2,4-dione",,1263133-33-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24808/7/4/2/?documentUUID=f0315371-8fdf-4726-97eb-341004bc7b1f,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=[N+](C(=C(C(=O)N2C=C1)C3=CC(=CC=C3)C(F)(F)F)[O-])CC4=CN=CN=C4,https://pubchem.ncbi.nlm.nih.gov/compound/57414497,PubChem,O=c1c(-c2cccc(C(F)(F)F)c2)c([O-])[n+](Cc2cncnc2)c2ccccn12,Train,63,1,testing
+"EU_REACH:
+bis((1S,2R,6R,7S,8R)-11-(dichloromethylidene)-6-hydroxytricyclo[6.2.1.0²,⁷]undecan-3-one)",,1263184-87-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5907/7/4/2/?documentUUID=7e241ccd-6ac1-45c5-a6d7-731de3526c8f,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC2C3C(C1C2=C(Cl)Cl)C(CCC3=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/67808389,PubChem,O=C1CCC(O)C2C3CCC(C3=C(Cl)Cl)C12,Train,64,1,testing
+"NZ_CCID:
+Succinchlorimide
+
+US_HSDB:
+N-Chlorosuccinimide","NZ_CCID:
+N-chlorosuccinimide",128-09-6,Cat 1,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/534B8FD5-DA7C-4C43-9EE6-E07C3A07252B
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/5407","NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,"NZ_CCID, US_HSDB",2,C1CC(=O)N(C1=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/31398,PubChem,O=C1CCC(=O)N1Cl,Train,65,1,testing
+"EU_REACH:
+2,4,6-triiodo-5-[2-(propan-2-yl)-1,3-dioxane-5-amido]benzene-1,3-dicarbonyl dichloride",,128286-13-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12470/7/4/2/?documentUUID=911b560a-bcd4-4335-9e72-a290fd6848c9,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1OCC(CO1)C(=O)NC2=C(C(=C(C(=C2I)C(=O)Cl)I)C(=O)Cl)I,https://pubchem.ncbi.nlm.nih.gov/compound/19825447,PubChem,CC(C)C1OCC(C(=O)Nc2c(I)c(C(=O)Cl)c(I)c(C(=O)Cl)c2I)CO1,Train,66,1,testing
+"NZ_CCID:
+Ethylmaleimide","NZ_CCID:
+N-Ethylmaleimide",128-53-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/66F99534-0D34-48D4-BDFD-9F372C4C240A,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 41 [Company Data]",,NZ_CCID,1,CCN1C(=O)C=CC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/4362,PubChem,CCN1C(=O)C=CC1=O,Train,67,1,testing
+"EU_CLP:
+2-isopropyl-2-(1-methylbutyl)-1,3-dimethoxypropane",,129228-11-1,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C)CCC(COC)(COC)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/10867702,PubChem,COCC(CCC(C)C)(COC)C(C)C,Test,68,2,testing
+"EU_CLP:
+2-isobutyl-2-isopropyl-1,3-dimethoxypropane",,129228-21-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C)CC(COC)(COC)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11138158,PubChem,COCC(COC)(CC(C)C)C(C)C,Test,68,2,testing
+"EU_REACH:
+tert-Butyl rel-(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoate",,129332-29-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16845/7/4/2/?documentUUID=21933193-8613-40fa-aebf-c01a4e2d0476,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)N1C2=CC=CC=C2C(=C1/C=C/[C@H](C[C@H](CC(=O)OC(C)(C)C)O)O)C3=CC=C(C=C3)F,https://pubchem.ncbi.nlm.nih.gov/compound/10115940,PubChem,CC(C)n1c(/C=C/[C@@H](O)C[C@@H](O)CC(=O)OC(C)(C)C)c(-c2ccc(F)cc2)c2ccccc21,Train,69,1,testing
+"US_HSDB:
+ARIPIPRAZOLE",,129722-12-9,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/7320,,,US_HSDB,1,C1CC(=O)NC2=C1C=CC(=C2)OCCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/60795,PubChem,O=C1CCc2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc2N1,Train,70,1,testing
+"EU_CLP:
+2,4-di-tert-butylcyclohexanone",,13019-04-0,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C)(C)C1CCC(=O)C(C1)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/114442,PubChem,CC(C)(C)C1CCC(=O)C(C(C)(C)C)C1,Test,71,1,testing
+"EU_REACH:
+4-(hydroxymethyl)-4-methyl-1-phenylpyrazolidin-3-one",,13047-13-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22579/7/4/2/?documentUUID=dfee286f-3d60-4e1b-bd9b-f2481508fea2,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(CN(NC1=O)C2=CC=CC=C2)CO,https://pubchem.ncbi.nlm.nih.gov/compound/92238,PubChem,CC1(CO)CN(c2ccccc2)NC1=O,Train,72,1,testing
+"US_HSDB:
+QUININE",,130-95-0,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/2501,,,US_HSDB,1,COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O,https://pubchem.ncbi.nlm.nih.gov/compound/1065,PubChem,C=CC1CN2CCC1CC2C(O)c1ccnc2ccc(OC)cc12,Train,73,1,testing
+"NZ_CCID:
+Rifampin","NZ_CCID:
+Rifampicin",13292-46-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CE8BF80D-0B37-442A-A717-2F521483D238,"NZ_CCID:
+Skin Irritation
+REMARK: Confidential information supplied by registrant.
+Eye Irritation
+REMARK: Confidential information supplied by registrant.",,NZ_CCID,1,C[C@H]1/C=C/C=C(\C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)[C@](O4)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C)O)O)/C=N\N5CCN(CC5)C)/C,https://pubchem.ncbi.nlm.nih.gov/compound/135550179,PubChem,CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N\N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C,Train,74,1,testing
+"US_HSDB:
+EPROSARTAN",,133040-01-4,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/7521,,,US_HSDB,1,CCCCC1=NC=C(N1CC2=CC=C(C=C2)C(=O)O)/C=C(\CC3=CC=CS3)/C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/5281037,PubChem,CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1,Train,75,1,testing
+"EU_CLP:
+(+)-(1S,2S,3S,5R)-2,6,6-trimethylbicyclo[3.1.1]heptane-3-spiro-1'-(cyclohex-2'-en-4'-one)",,133636-82-5,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C[C@H]1[C@@H]2C[C@@H](C2(C)C)C[C@]13CCC(=O)C=C3,https://pubchem.ncbi.nlm.nih.gov/compound/117859414,PubChem,C[C@H]1[C@@H]2C[C@H](C[C@@]13C=CC(=O)CC3)C2(C)C,Test,76,1,testing
+"EU_REACH:
+2,2'-diazene-1,2-diylbis(2-methylbutanenitrile)",,13472-08-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5486/7/4/2/?documentUUID=ece7fdf3-fec2-49ad-8eaf-1fdb6d1f3467,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(C)(C#N)N=NC(C)(CC)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/93079,PubChem,CCC(C)(C#N)N=NC(C)(C#N)CC,Train,77,3,testing
+"EU_REACH:
+4,4'-azobis[4-cyanovaleric] acid",,2638-94-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22344/7/4/2/?documentUUID=d476a90f-8273-4331-ad8a-fa63904937ec,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CCC(=O)O)(C#N)N=NC(C)(CCC(=O)O)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/92938,PubChem,CC(C#N)(CCC(=O)O)N=NC(C)(C#N)CCC(=O)O,Train,77,3,testing
+"JP_CHRIP:
+2,2'-Azobisisobutyronitrile","JP_CHRIP:
+2,2'-Azobis(2-methylpropanenitrile)
+2,2'-Azobisisobutyronitrile",78-67-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-meti-0024e.html,"JP_CHRIP:
+There is a description that in the skin irritation test (OECD TG 404), as a result of a 4-hour semi-occlusive application of 500 mg of this substance to rabbits, no irritation was observed (SIDS (2002), Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)). Other than this, there is a report that no irritation was observed in a 24-hour application test with rabbits, and it is described in two reports of skin irritation tests with guinea pigs (application time is unknown) that no irritation was observed or that slight irritation was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)). Since no irritation was observed in the test according to the test guidelines, it was classified as ""Not classified.""",Provided,JP_CHRIP,1,CC(C)(N=NC(C)(C)C#N)C#N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.955K,J-GLOBAL,CC(C)(C#N)N=NC(C)(C)C#N,Train,77,3,testing
+"EU_CLP:
+acibenzolar-S-methyl; benzo[1,2,3]thiadiazole-7-carbothioic acid S-methyl ester",,135158-54-2,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CSC(=O)C1=C2C(=CC=C1)N=NS2,https://pubchem.ncbi.nlm.nih.gov/compound/86412,PubChem,CSC(=O)c1cccc2nnsc12,Test,78,1,testing
+"NZ_CCID:
+Pindolol","NZ_CCID:
+(RS)-Pindolol, (±)-Pindolol, DL-Pindolol",13523-86-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AA127767-358D-4D19-8300-43BDAA2628AE,"NZ_CCID:
+Skin Irritation
+REMARK: Confidential information supplied by registrant
+Eye Irritation
+REMARK: Confidential information supplied by registrant",,NZ_CCID,1,CC(C)NCC(COC1=CC=CC2=C1C=CN2)O,https://pubchem.ncbi.nlm.nih.gov/compound/4828,PubChem,CC(C)NCC(O)COc1cccc2[nH]ccc12,Train,79,1,testing
+"EU_REACH:
+(1R)-1-[(4R,4aR,8aS)-2,6-bis(3,4-dimethylphenyl)tetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol",,135861-56-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8016/7/4/2/?documentUUID=aad19ea0-46d5-4012-a320-703f2f851f28,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)C2OC[C@H]3[C@@H](O2)[C@H](OC(O3)C4=CC(=C(C=C4)C)C)[C@@H](CO)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/18666587,PubChem,Cc1ccc(C2OC[C@@H]3OC(c4ccc(C)c(C)c4)O[C@H]([C@H](O)CO)[C@@H]3O2)cc1C,Train,80,1,testing
+"NZ_CCID:
+Hydrocortisone butyrate",,13609-67-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B150C960-7E45-41CC-BE1B-2B75423B9E1E,"NZ_CCID:
+Skin Irritation
+REMARK: Confidential information supplied by registrant.
+Eye Irritation
+REMARK: Confidential information supplied by registrant.",,NZ_CCID,1,CCCC(=O)O[C@@]1(CC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)O)C)C(=O)CO,https://pubchem.ncbi.nlm.nih.gov/compound/26133,PubChem,CCCC(=O)O[C@]1(C(=O)CO)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C,Train,81,2,testing
+"NZ_CCID:
+Budesonide",,51333-22-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DD22BDB7-18B9-430B-8EB2-581344230CCD,"NZ_CCID:
+Skin Irritation
+REMARK: Confidential information supplied by registrant
+Eye Irritation
+REMARK: Confidential information supplied by registrant",,NZ_CCID,1,CCCC1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@@]5([C@H]4[C@H](C[C@@]3([C@@]2(O1)C(=O)CO)C)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/5281004,PubChem,CCCC1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1,Train,81,2,testing
+"KR_NCIS:
+1,4-Dithiane-2,5-di(methanethiol)",,136122-15-1,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C1C(SCC(S1)CS)CS,https://pubchem.ncbi.nlm.nih.gov/compound/11401600,PubChem,SCC1CSC(CS)CS1,Train,82,1,testing
+"NZ_CCID:
+1,1-Bis(methylthio)-2-nitroethylene",,13623-94-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9A8B2402-FCBF-461D-B480-F5CAC02D2576,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CSC(=C[N+](=O)[O-])SC,https://pubchem.ncbi.nlm.nih.gov/compound/83623,PubChem,CSC(=C[N+](=O)[O-])SC,Train,83,1,testing
+"EU_CLP:
+fluquinconazole (ISO); 3-(2,4-dichlorophenyl)-6-fluoro-2-(1H-1,2,4-triazol-1-yl)quinazolin-4-(3H)-one",,136426-54-5,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC2=C(C=C1F)C(=O)N(C(=N2)N3C=NC=N3)C4=C(C=C(C=C4)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/86417,PubChem,O=c1c2cc(F)ccc2nc(-n2cncn2)n1-c1ccc(Cl)cc1Cl,Test,84,1,testing
+"EU_REACH:
+2-[(2-{bis[(dioctadecylcarbamoyl)methyl]amino}ethyl)[(dioctadecylcarbamoyl)methyl]amino]-N,N-dioctadecylacetamide",,136920-07-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18106/7/4/2/?documentUUID=538f48e7-efc5-4301-afc3-966b41998e4f,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/6083,PubChem,Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O,Train,85,2,testing
+"EU_REACH:
+nadide",,53-84-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10862/7/4/2/?documentUUID=d9a63255-0caa-44bd-82b7-186b21220c11,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)OP(=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/5893,PubChem,NC(=O)c1ccc[n+]([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)c1,Train,85,2,testing
+"EU_REACH:
+4-(2-{2-amino-4-oxo-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)benzoic acid",,137281-39-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/3392/7/4/2/?documentUUID=9c93dd05-0446-4aeb-993c-a8dcfbfd298b,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/135405776,PubChem,Nc1nc2[nH]cc(CCc3ccc(C(=O)O)cc3)c2c(=O)[nH]1,Train,86,1,testing
+"EU_REACH:
+tert-Butyl 4-({6-[7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}pyridin-3-yl)piperazine-1-carboxylate",,1374639-78-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27666/7/4/2/?documentUUID=7406d2ef-a58e-4510-ba25-56b8c67dd94c,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)OC(=O)N1CCN(CC1)C2=CN=C(C=C2)NC3=NC=C4C=C(N(C4=N3)C5CCCC5)C(=O)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/67354206,PubChem,CN(C)C(=O)c1cc2cnc(Nc3ccc(N4CCN(C(=O)OC(C)(C)C)CC4)cn3)nc2n1C1CCCC1,Train,87,2,testing
+"EU_REACH:
+tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate",,571188-59-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18360/7/4/2/?documentUUID=c8d68cf9-e328-4976-b049-a3e357bd6227,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)OC(=O)N1CCN(CC1)C2=CN=C(C=C2)N,https://pubchem.ncbi.nlm.nih.gov/compound/11737525,PubChem,CC(C)(C)OC(=O)N1CCN(c2ccc(N)nc2)CC1,Test,87,2,testing
+"EU_CLP:
+4-ethyl-2-methyl-2-isopentyl-1,3-oxazolidine",,137796-06-6,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCC1COC(N1)(C)CCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/5105001,PubChem,CCC1COC(C)(CCC(C)C)N1,Test,88,2,testing
+"KR_NCIS:
+3-Ethyl-2-methyl-2-(3-methylbutyl)-1,3-oxazolidine",,143860-04-2,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCN1CCOC1(C)CCC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/4199499,PubChem,CCN1CCOC1(C)CCC(C)C,Train,88,2,testing
+"EU_CLP:
+butroxydim (ISO); 5-(3-butyryl-2,4,6-trimethylphenyl)-2-[1-(ethoxyimino)propyl]-3-hydroxycyclohex-2-en-1-one",,138164-12-2,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCCC(=O)C1=C(C=C(C(=C1C)C2CC(=C(C(=O)C2)/C(=N\OCC)/CC)O)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/135797834,PubChem,CCCC(=O)c1c(C)cc(C)c(C2CC(=O)C(/C(CC)=N\OCC)=C(O)C2)c1C,Test,89,2,testing
+"NZ_CCID:
+Clethodim",,99129-21-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/12E08166-4EDC-4A65-B252-F8B1FFAFCE05,"NZ_CCID:
+Skin Irritation
+SPECIES: Rabbit
+RESULT: Moderate
+REFERENCE SOURCE: [Pesticides Manual]
+Eye Irritation
+SPECIES: Rabbit
+RESULT: Mildly irritating
+REFERENCE SOURCE: (Cushman et al., 1986a). (Clethodim - Pesticide residues in food: 1994 evaluations Part II Toxicology) [INCHEM]
+REMARK: Undiluted technical-grade clethodim (purity, 83.3%) was used for this experiment.",,NZ_CCID,1,CC/C(=N\OC/C=C/Cl)/C1=C(CC(CC1=O)CC(C)SCC)O,https://pubchem.ncbi.nlm.nih.gov/compound/135491728,PubChem,CCSC(C)CC1CC(=O)C(/C(CC)=N/OC/C=C/Cl)=C(O)C1,Train,89,2,testing
+"EU_REACH:
+1-difluoromethanesulfonyl-3-(4,6-dimethoxy-1,3,5-triazin-2-yl)-7-fluoro-1H-indol-2-ol",,1383692-20-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18053/7/4/2/?documentUUID=d31db7aa-e1b8-4361-bfbe-1be8b1745ba3,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=NC(=NC(=N1)C2=C(N(C3=C2C=CC=C3F)S(=O)(=O)C(F)F)O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/136338231,PubChem,COc1nc(OC)nc(-c2c(O)n(S(=O)(=O)C(F)F)c3c(F)cccc23)n1,Train,90,2,testing
+"EU_REACH:
+N-{2-[(4,6-dimethoxy-1,3,5-triazin-2-yl)carbonyl]-6-fluorophenyl}-1,1-difluoro-N-methylmethanesulfonamide",,874195-61-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6582/7/4/2/?documentUUID=442ff565-b688-403e-a0b3-1ddce977f863,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C1=C(C=CC=C1F)C(=O)C2=NC(=NC(=N2)OC)OC)S(=O)(=O)C(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/16004663,PubChem,COc1nc(OC)nc(C(=O)c2cccc(F)c2N(C)S(=O)(=O)C(F)F)n1,Train,90,2,testing
+"EU_REACH:
+3-(4,6-dimethoxy-1,3,5-triazin-2-yl)-7-fluoro-2,3-dihydro-1H-indol-2-one",,1383706-71-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18051/7/4/2/?documentUUID=1a8dc607-8ac9-4dae-8681-316b8d976cb3,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=NC(=NC(=N1)C2C3=C(C(=CC=C3)F)NC2=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/67982437,PubChem,COc1nc(OC)nc(C2C(=O)Nc3c(F)cccc32)n1,Train,91,1,testing
+"EU_REACH:
+(3R,4R)-1,1,1,2,2,3,4,5,5,5-decafluoropentane; (3S,4S)-1,1,1,2,2,3,4,5,5,5-decafluoropentane",,138495-42-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5463/7/4/2/?documentUUID=f59b478a-81f6-45e4-8652-ea5caf04dbef,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(C(C(F)(F)F)F)(C(C(F)(F)F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/86240,PubChem,FC(C(F)C(F)(F)C(F)(F)F)C(F)(F)F,Train,92,1,testing
+"EU_REACH:
+(1R,2R)-1,3-Dihydroxy-1-(4-nitrophenyl)propyl-2-ammonium (1R, 5S)-5-(dimethylphenylsilyl)-2-(hydroxymethyl)cyclopent-2-ene-1-carboxylate",,1388152-30-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5606/7/4/2/?documentUUID=fcb75064-659a-46be-9332-15536ebf75d1,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](C)([C@H]1CC=C([C@@H]1C(=O)O[C@](C2=CC=C(C=C2)[N+](=O)[O-])([C@@H](CO)N)O)CO)C3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/165362778,PubChem,C[Si](C)(c1ccccc1)[C@H]1CC=C(CO)[C@@H]1C(=O)O[C@](O)(c1ccc([N+](=O)[O-])cc1)[C@H](N)CO,Train,93,1,testing
+"KR_NCIS:
+6,6a,7,8,9,9a-Hexahydro-7,7,8,9,9-pentamethyl-5H-cyclopenta[h]quinazoline",,1392325-86-8,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CC1C(C2CCC3=CN=CN=C3C2C1(C)C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/68162000,PubChem,CC1C(C)(C)C2CCc3cncnc3C2C1(C)C,Train,94,1,testing
+"EU_REACH:
+tert-butyl 5'-acetyl-3'H-spiro[azetidine-3,1'-isobenzofuran]-1-carboxylate",,1398609-81-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32316/7/4/2/?documentUUID=9faf662a-d72a-4160-8919-adf0e30a2741,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)C1=CC2=C(C=C1)C3(CN(C3)C(=O)OC(C)(C)C)OC2,https://pubchem.ncbi.nlm.nih.gov/compound/70663143,PubChem,CC(=O)c1ccc2c(c1)COC21CN(C(=O)OC(C)(C)C)C1,Train,95,1,testing
+"EU_REACH:
+2-[3-(heptan-3-yl)-1,2-oxazolidin-2-yl]ethyl N-{6-[({2-[3-(heptan-3-yl)-1,2-oxazolidin-2-yl]ethoxy}carbonyl)amino]hexyl}carbamate",,140921-24-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11360/7/4/2/?documentUUID=f7bc5de0-4d9d-45a1-8f88-4039dd309fbb,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)C1N(CCO1)CCOC(=O)NCCCCCCNC(=O)OCCN2CCOC2C(CC)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/14993651,PubChem,CCCCC(CC)C1OCCN1CCOC(=O)NCCCCCCNC(=O)OCCN1CCOC1C(CC)CCCC,Train,96,2,testing
+"EU_REACH:
+3-butyl-2-(heptan-3-yl)-1,3-oxazolidine",,165101-57-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10626/7/4/2/?documentUUID=d62fc6b0-d89f-4d41-828b-dd25d80f7445,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)C1N(CCO1)CCCC,https://pubchem.ncbi.nlm.nih.gov/compound/3297025,PubChem,CCCCC(CC)C1OCCN1CCCC,Train,96,2,testing
+"EU_REACH:
+(3E)-2-chloro-3-(hydroxymethylidene)cyclohex-1-ene-1-carbaldehyde",,1416808-92-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11440/7/4/2/?documentUUID=3047dce7-586b-4c30-8ddd-12690267cc91,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C/C(=C\O)/C(=C(C1)C=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10986754,PubChem,O=CC1=C(Cl)/C(=C/O)CCC1,Train,97,1,testing
+"EU_REACH:
+(2R,3S,4S)-2,3,4-tris(benzyloxy)-4-[(4R)-4-[(benzyloxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl]-1-(4-methylpiperazin-1-yl)butan-1-one",,1431329-07-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11399/7/4/2/?documentUUID=b40aa173-c193-4d70-87e4-f3de70865226,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(OC[C@](O1)(COCC2=CC=CC=C2)[C@H]([C@@H]([C@H](C(=O)N3CCN(CC3)C)OCC4=CC=CC=C4)OCC5=CC=CC=C5)OCC6=CC=CC=C6)C,https://pubchem.ncbi.nlm.nih.gov/compound/126582620,PubChem,CN1CCN(C(=O)[C@H](OCc2ccccc2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@@]2(COCc3ccccc3)COC(C)(C)O2)CC1,Test,98,1,testing
+"JP_CHRIP:
+Chlordecone","JP_CHRIP:
+1,1a,3,3a,4,5,5,5a,5b,6-Decachloro-octahydro-1,3,4-metheno-2H-cyclobuta(cd)pentalen-2-one
+1,2,3,4,6,7,8,9,10,10-Decachloropentacyclo[5.3.0.0(2,6).0(3,9).0(4,8)]decan-5-one
+1,3,4-Metheno-2H-cyclobuta[cd]pentalen-2-one, 1,1a,3,3a,4,5,5,5a,5b,6-decachlorooctahydro-
+Chlordecone
+Chlordecone (Kepone)
+Decachloroketone
+Kepone
+Kepone(R)",143-50-0,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/07-mhlw-0063e.html,"JP_CHRIP:
+Some workers exposed to high levels of this substance showed signs of skin irritation (ATSDR, 1995). Thus, the substance was classified into Category 2.",,JP_CHRIP,1,ClC12C(=O)C3(Cl)C4(Cl)C1(Cl)C1(Cl)C2(Cl)C3(Cl)C4(Cl)C1(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J10.213J,J-GLOBAL,O=C1C2(Cl)C3(Cl)C4(Cl)C(Cl)(Cl)C5(Cl)C3(Cl)C1(Cl)C5(Cl)C24Cl,Train,99,2,testing
+"JP_CHRIP:
+Mirex","JP_CHRIP:
+1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachloro-octahydro-1,3,4-metheno-1H-cyclobuta(cd)pentalene
+1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro-1,3,4-metheno-1H-cyclobuta[cd]pentalene
+1,2,3,4,5,5,6,7,8,9,10,10-Dodecachloropentacyclo[5.3.0.0(2,6).0(3,9).0(4,8)]decane
+1,3,4-Metheno-1H-cyclobuta[cd]pentalene, 1,1a,2,2,3,3a,4,5,5,5a,5b,6-dodecachlorooctahydro-
+Mirex",2385-85-5,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/07-mhlw-0096e.html,"JP_CHRIP:
+Based on the report that it is a moderate skin irritant (HSDB, 2007), the substance was classified into Category 2.",,JP_CHRIP,1,ClC12C3(Cl)C4(Cl)C5(Cl)C(Cl)(C1(Cl)C4(Cl)Cl)C2(Cl)C(Cl)(Cl)C35Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J8.588J,J-GLOBAL,ClC1(Cl)C2(Cl)C3(Cl)C4(Cl)C(Cl)(Cl)C5(Cl)C3(Cl)C1(Cl)C5(Cl)C24Cl,Train,99,2,testing
+"NZ_CCID:
+3-Aminorhodanine","NZ_CCID:
+N-Aminorhodanine",1438-16-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/881B827D-A7B3-4A51-AD38-3B45FC87EBE2,"NZ_CCID:
+Skin Irritation
+R-PHRASE: R 38. [Company data]
+Eye Irritation
+R-PHRASE: R 36. [Company data]",,NZ_CCID,1,C1C(=O)N(C(=S)S1)N,https://pubchem.ncbi.nlm.nih.gov/compound/74033,PubChem,NN1C(=O)CSC1=S,Train,100,1,testing
+"EU_REACH:
+9-bromo-3-(2-bromoacetyl)-8,9,10,11-tetrahydro-5H-6-oxatetraphen-8-one",,1438383-89-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16398/7/4/2/?documentUUID=51b6a241-0cc9-44dc-ac48-6f1ecc816ad0,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC2=CC3=C(C=C2C(=O)C1Br)OCC4=C3C=CC(=C4)C(=O)CBr,https://pubchem.ncbi.nlm.nih.gov/compound/86688372,PubChem,O=C(CBr)c1ccc2c(c1)COc1cc3c(cc1-2)CCC(Br)C3=O,Train,101,1,testing
+"JP_CHRIP:
+N-methyldithiocarbamic acid","JP_CHRIP:
+N-Methyldithiocarbamic acid
+N-methyldithiocarbamic acid (synonym:carbam)",144-54-7,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0499e.html,"JP_CHRIP:
+Based on the evidence of destruction of skin tissues observed in rabbit skin irritation tests (24 hour application) (Agricultural Chemical Registration Data (1987)).",,JP_CHRIP,1,CNC(=S)S,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J9.912K,J-GLOBAL,CNC(=S)S,Train,102,3,testing
+"JP_CHRIP:
+Ammonium methylcarbamodithioate; Metam-ammonium","JP_CHRIP:
+ammonium N-methyldithiocarbamate
+Carbamodithioic acid, N-methyl-, ammonium salt (1:1)
+Methyldithiocarbamic acid, ammonium salt",39680-90-5,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-0027e.html,"JP_CHRIP:
+[Rationale for the Classification]
+It was classified in Category 1 from (1).
+
+[Evidence Data]
+(1) In a skin irritation test with rabbits, tissue destruction was observed, and it was judged as corrosive (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)).",,JP_CHRIP,1,CNC(=S)S[N+],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.040E,J-GLOBAL,CNC(=S)S[N+],Train,102,3,testing
+"EU_REACH:
+1-amino-3-methylthiourea",,6610-29-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10986/7/4/2/?documentUUID=00cce467-247b-4fc8-8677-477e30237dcc,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CNC(=S)NN,https://pubchem.ncbi.nlm.nih.gov/compound/2723853,PubChem,CNC(=S)NN,Train,102,3,testing
+"NZ_CCID:
+Dehydroabietylamine (mixture of isomeres)","NZ_CCID:
+dehydroabietylamine",1446-61-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/108391B1-B714-451B-B37F-CD62BD977A9D,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC(C)C1=CC2=C(C=C1)[C@]3(CCC[C@@]([C@@H]3CC2)(C)CN)C,https://pubchem.ncbi.nlm.nih.gov/compound/62034,PubChem,CC(C)c1ccc2c(c1)CC[C@H]1[C@](C)(CN)CCC[C@]21C,Train,103,1,testing
+"EU_REACH:
+(4E)-5-cyclohexyl-2,4-dimethylpent-4-enal",,1449104-34-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29595/7/4/2/?documentUUID=3a7d568c-6692-418e-af21-2e700a929fac,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C/C(=C/C1CCCCC1)/C)C=O,https://pubchem.ncbi.nlm.nih.gov/compound/89738936,PubChem,C/C(=C\C1CCCCC1)CC(C)C=O,Train,104,1,testing
+"NZ_CCID:
+3-Methylpyrazole",,1453-58-3,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8DBC3FE9-D4F1-49F1-9E5C-6A792A326ACB,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=CC=NN1,https://pubchem.ncbi.nlm.nih.gov/compound/15073,PubChem,Cc1ccn[nH]1,Train,105,1,testing
+"EU_REACH:
+2-[9-(1-hydroxy-2-methylpropan-2-yl)-2,4,8,10-tetraoxaspiro[5.5]undecan-3-yl]-2-methylpropan-1-ol",,1455-42-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13316/7/4/2/?documentUUID=1341c6fd-d38d-4e03-8829-018dcfa7c7f2,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(CO)C1OCC2(CO1)COC(OC2)C(C)(C)CO,https://pubchem.ncbi.nlm.nih.gov/compound/7569008,PubChem,CC(C)(CO)C1OCC2(CO1)COC(C(C)(C)CO)OC2,Train,106,1,testing
+"NZ_CCID:
+Sporidesmin A",,1456-55-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7ADFF862-253C-4469-958B-1EB25C1097F2,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [CHEMWATCH]
+Eye Irritation
+R PHRASE: R 36 [CHEMWATCH]",,NZ_CCID,1,C[C@@]12C(=O)N3[C@@H]4[C@]([C@H]([C@]3(C(=O)N1C)SS2)O)(C5=CC(=C(C(=C5N4C)OC)OC)Cl)O,https://pubchem.ncbi.nlm.nih.gov/compound/99596,PubChem,COc1c(Cl)cc2c(c1OC)N(C)[C@@H]1N3C(=O)[C@@]4(C)SS[C@@]3(C(=O)N4C)[C@H](O)[C@]21O,Train,107,1,testing
+"EU_REACH:
+4,6-dichloro-5-nitro-2-(propylsulfanyl)pyrimidine",,145783-14-8,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5571/7/4/2/?documentUUID=3bdb52d4-39f7-4e66-9c5a-0cb30ee63104,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCSC1=NC(=C(C(=N1)Cl)[N+](=O)[O-])Cl,https://pubchem.ncbi.nlm.nih.gov/compound/22268924,PubChem,CCCSc1nc(Cl)c([N+](=O)[O-])c(Cl)n1,Test,108,1,testing
+"NZ_CCID:
+Nitrazepam",,146-22-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7CA03CAF-C412-4F11-8666-B04A2977C151,"NZ_CCID:
+Skin Irritation
+REMARK: Confidential information supplied by registrant.
+Eye Irritation
+REMARK: Confidential information supplied by registrant.",,NZ_CCID,1,C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/4506,PubChem,O=C1CN=C(c2ccccc2)c2cc([N+](=O)[O-])ccc2N1,Train,109,3,testing
+"NZ_CCID:
+Oxazepam","NZ_CCID:
+(RS)-Oxazepam, (±)-Oxazepam",604-75-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7A72BC95-CBCF-4615-8CCD-D8445DC5EFC3,"NZ_CCID:
+Skin Irritation
+REMARK: Confidential information supplied by registrant
+Eye Irritation
+REMARK: Confidential information supplied by registrant",,NZ_CCID,1,C1=CC=C(C=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O,https://pubchem.ncbi.nlm.nih.gov/compound/4616,PubChem,O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=NC1O,Train,109,3,testing
+"NZ_CCID:
+Lorazepam","NZ_CCID:
+(RS)-Lorazepam, (±)-Lorazepam",846-49-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DA35864F-0B49-4AA1-8178-D82D608E9E49,"NZ_CCID:
+Skin Irritation
+REMARK: Confidential information supplied by registrant
+Eye Irritation
+REMARK: Confidential information supplied by registrant",,NZ_CCID,1,C1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/3958,PubChem,O=C1Nc2ccc(Cl)cc2C(c2ccccc2Cl)=NC1O,Train,109,3,testing
+"US_HSDB:
+Ziprasidone",,146939-27-7,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/7745,,,US_HSDB,1,C1CN(CCN1CCC2=C(C=C3C(=C2)CC(=O)N3)Cl)C4=NSC5=CC=CC=C54,https://pubchem.ncbi.nlm.nih.gov/compound/60854,PubChem,O=C1Cc2cc(CCN3CCN(c4nsc5ccccc45)CC3)c(Cl)cc2N1,Train,110,1,testing
+"EU_REACH:
+(2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxy-phenyl)methyl]quinuclidin-3-amine",,147116-67-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29628/7/4/2/?documentUUID=b9cffed0-8570-41bc-a19f-c8ee4e59ee96,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1=CC(=C(C=C1)OC)CN[C@@H]2[C@@H](N3CCC2CC3)C(C4=CC=CC=C4)C5=CC=CC=C5,https://pubchem.ncbi.nlm.nih.gov/compound/204108,PubChem,COc1ccc(C(C)(C)C)cc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1,Train,111,1,testing
+"EU_CLP:
+isobutylidene-(2-(2-isopropyl-4,4-dimethyloxazolidine-3-yl)-1,1-dimethylethyl)amine",,148348-13-4,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C)C=NC(C)(C)CN1C(OCC1(C)C)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/3892206,PubChem,CC(C)C=NC(C)(C)CN1C(C(C)C)OCC1(C)C,Test,112,4,testing
+"AU_HCIS:
+1H,3H,5H-Oxazolo[3,4-c]oxazole-7a(7H)-methanol",,6542-37-6,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5835,,,AU_HCIS,1,C1C2(COCN2CO1)CO,https://pubchem.ncbi.nlm.nih.gov/compound/62612,PubChem,OCC12COCN1COC2,Train,112,4,testing
+"AU_HCIS:
+1H,3H,5H-Oxazolo[3,4-c]oxazole, 7a-ethyldihydro-",,7747-35-5,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5836,,,AU_HCIS,1,CCC12COCN1COC2,https://pubchem.ncbi.nlm.nih.gov/compound/82190,PubChem,CCC12COCN1COC2,Train,112,4,testing
+"EU_CLP:
+7a-ethyl-3,5-bis(1-methylethyl)-2,3,4,5-tetrahydrooxazolo[3,4-c]-2,3,4,5-tetrahydrooxazole",,79185-77-6,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCC12COC(N1C(OC2)C(C)C)C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/3664989,PubChem,CCC12COC(C(C)C)N1C(C(C)C)OC2,Test,112,4,testing
+"EU_CLP:
+9-vinylcarbazole",,1484-13-5,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C=CN1C2=CC=CC=C2C3=CC=CC=C31,https://pubchem.ncbi.nlm.nih.gov/compound/15143,PubChem,C=Cn1c2ccccc2c2ccccc21,Test,113,3,testing
+"EU_REACH:
+2,20-dichloro-13,31-diethyl-4,22-dioxa-13,18,31,36-tetraazanonacyclo[19.15.0.0³,¹⁹.0⁵,¹⁷.0⁶,¹⁴.0⁷,¹².0²³,³⁵.0²⁴,³².0²⁵,³⁰]hexatriaconta-1(36),2,5,7(12),8,10,14,16,18,20,23(35),24(32),25,27,29,33-hexadecaene",,215247-95-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18047/7/4/2/?documentUUID=01c5813b-03b1-460a-9d6b-5fac4420fc3c,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN1C2=C(C3=CC=CC=C31)C4=C(C=C2)N=C5C(=C(C6=NC7=C(C8=C(C=C7)N(C9=CC=CC=C98)CC)OC6=C5Cl)Cl)O4,https://pubchem.ncbi.nlm.nih.gov/compound/11845128,PubChem,CCn1c2ccccc2c2c3c(ccc21)N=c1c(Cl)c2c(c(Cl)c1O3)=Nc1ccc3c(c1O2)c1ccccc1n3CC,Train,113,3,testing
+"EU_REACH:
+9-ethyl-9H-carbazole",,86-28-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5801/7/4/2/?documentUUID=1685823b-dd0c-476c-8ff1-a9ba327832c5,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN1C2=CC=CC=C2C3=CC=CC=C31,https://pubchem.ncbi.nlm.nih.gov/compound/6836,PubChem,CCn1c2ccccc2c2ccccc21,Train,113,3,testing
+"JP_CHRIP:
+ethoxydimethylsilane","JP_CHRIP:
+Dimethylethoxysilane",14857-34-2,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0789e.html,"JP_CHRIP:
+It showed slight to moderate stimulativeness in the skin irritation test on rabbits (ACGIH 7th, 2001).Therefore, it was classified as Category 2.",,JP_CHRIP,1,CCO[SiH](C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J227.212A,J-GLOBAL,CCO[SiH](C)C,Train,114,1,testing
+"JP_CHRIP:
+Melphalan","JP_CHRIP:
+Melphalan",148-82-3,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0226e.html,"JP_CHRIP:
+Based on a report that application to rabbits produced ""mild to moderate"" skin irritation and histopathological examination confirmed mild irritant (HSDB (2009)), the substance was classified into Category 2.",,JP_CHRIP,1,N[C@@H](Cc1ccc(cc1)N(CCCl)CCCl)C(=O)O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.962I,J-GLOBAL,N[C@@H](Cc1ccc(N(CCCl)CCCl)cc1)C(=O)O,Train,115,1,testing
+"EU_REACH:
+3-methyl-N-nitro-3,6-dihydro-2H-1,3,5-oxadiazin-4-amine",,153719-38-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5312/7/4/2/?documentUUID=dc9602a3-35fe-4b79-b9bb-7c176c33a91c,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN1COCN=C1N[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/10888198,PubChem,CN1COCN=C1N[N+](=O)[O-],Train,116,1,testing
+"EU_CLP:
+2-isopropyl-4-(N-methyl)aminomethylthiazole",,154212-60-9,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C)C1=NC(=CS1)CNC,https://pubchem.ncbi.nlm.nih.gov/compound/10749687,PubChem,CNCc1csc(C(C)C)n1,Test,117,1,testing
+"NZ_CCID:
+1-(Trifluoroacetyl)-1H-imidazole","NZ_CCID:
+1-(trifluoroacetyl)imidazole, N-Trifluoroacetylimidazole",1546-79-8,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E534FC40-175A-4CDA-A0E9-E4F68A035F0A,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1=CN(C=N1)C(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/73767,PubChem,O=C(n1ccnc1)C(F)(F)F,Train,118,3,testing
+"NZ_CCID:
+1,1'-Carbonyldiimidazole",,530-62-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BBC0EE51-F594-4A97-BA1F-E5B92813B4B1,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CN(C=N1)C(=O)N2C=CN=C2,https://pubchem.ncbi.nlm.nih.gov/compound/68263,PubChem,O=C(n1ccnc1)n1ccnc1,Train,118,3,testing
+"NZ_CCID:
+1-Methylimidazole",,616-47-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DA4F367E-F23D-4BC9-9F09-0023B04783D2,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CN1C=CN=C1,https://pubchem.ncbi.nlm.nih.gov/compound/1390,PubChem,Cn1ccnc1,Train,118,3,testing
+"EU_REACH:
+(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol",,156928-09-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25771/7/4/2/?documentUUID=d243b303-bff3-49b7-85f1-0533896984da,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CO[C@H]2[C@@H]1[C@H](CO2)O,https://pubchem.ncbi.nlm.nih.gov/compound/9942150,PubChem,O[C@H]1CO[C@H]2OCC[C@H]21,Train,119,2,testing
+"EU_REACH:
+1,4:3,6-dianhydro-D-glucitol",,652-67-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5661/7/4/2/?documentUUID=a578aafc-d6e2-4d0c-a70a-934b4bbf598c,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1[C@H]([C@@H]2[C@H](O1)[C@H](CO2)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/12597,PubChem,O[C@@H]1CO[C@H]2[C@@H]1OC[C@@H]2O,Train,119,2,testing
+"NZ_CCID:
+1,1,3,3-Tetramethyldisilazane",,15933-59-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/046FF292-9046-4B4F-9382-D4EA76F68C58,"NZ_CCID:
+Skin Irritation
+UN CLASS: 3; 8; PGII
+Eye Irritation
+UN CLASS: 3; 8; PGII",,NZ_CCID,1,C[Si](C)N[Si](C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6327317,PubChem,C[Si](C)N[Si](C)C,Train,120,1,testing
+"EU_CLP:
+dodemorph (ISO); 4-cyclododecyl-2,6-dimethylmorpholine",,1593-77-7,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC1CN(CC(O1)C)C2CCCCCCCCCCC2,https://pubchem.ncbi.nlm.nih.gov/compound/61899,PubChem,CC1CN(C2CCCCCCCCCCC2)CC(C)O1,Test,121,1,testing
+"EU_REACH:
+propan-2-yl (1R,3S,4R,5R)-3-azido-5-hydroxy-4-{[(2S,3S,4R,5R,6S)-3,4,5-tris(benzyloxy)-6-methyloxan-2-yl]oxy}cyclohexane-1-carboxylate",,1620677-97-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18013/7/4/2/?documentUUID=77e567d8-9577-4ea6-a136-e8ddc1bf8848,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@H]1[C@H]([C@H]([C@@H]([C@@H](O1)O[C@@H]2[C@H](C[C@H](C[C@H]2O)C(=O)OC(C)C)N=[N+]=[N-])OCC3=CC=CC=C3)OCC4=CC=CC=C4)OCC5=CC=CC=C5,https://pubchem.ncbi.nlm.nih.gov/compound/154734785,PubChem,CC(C)OC(=O)[C@H]1C[C@@H](O)[C@H](O[C@@H]2O[C@@H](C)[C@@H](OCc3ccccc3)[C@@H](OCc3ccccc3)[C@@H]2OCc2ccccc2)[C@@H](N=[N+]=[N-])C1,Train,122,1,testing
+"JP_CHRIP:
+5-Ethylidene-2-norbornene; Ethylidene norbornene","JP_CHRIP:
+5-Ethylidenebicyclo(2,2,1)hep-2-ene
+Bicyclo[2.2.1]hept-2-ene, 5-ethylidene-
+ENB
+Ethylidene norbornene
+Ethylidenenorbornene",16219-75-3,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2086e.html,"JP_CHRIP:
+[Rationale for the Classification]
+It was classified in Category 2 from (1). The classification result was changed because new data were obtained.
+
+[Evidence Data]
+(1) In a skin irritation test comparable to OECD TG 404 with rabbits, mild to moderate erythema and edema were observed, and desquamation was seen in all animals from day 7, but they recovered by day 14 (SIAR (2005), Patty (6th, 2012)).",Provided,JP_CHRIP,1,CC=C1CC2CC1C=C2,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J14.767B,J-GLOBAL,CC=C1CC2C=CC1C2,Train,123,1,testing
+"EU_REACH:
+2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoic acid",,162537-11-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19495/7/4/2/?documentUUID=cbf62ac8-d90b-45c6-8a96-619549084d30,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)[C@@H](C(=O)O)NC(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/11263950,PubChem,COC(=O)N[C@H](C(=O)O)C(C)(C)C,Train,124,1,testing
+"EU_REACH:
+5-[3-(1-ethoxyethoxy)-3-methyl-4-penten-1-ynyl]-2,4,6,6-tetramethyl-5,6,7,7a-tetrahydro-1,3-benzodioxol-5-ol",,162691-59-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17392/7/4/2/?documentUUID=b70962ba-3165-4234-9a3c-bbdca7604049,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(C)OC(C)(C=C)C#CC1(C(=C2C(CC1(C)C)OC(O2)C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/11132254,PubChem,C=CC(C)(C#CC1(O)C(C)=C2OC(C)OC2CC1(C)C)OC(C)OCC,Train,125,1,testing
+"KR_NCIS:
+1-Cyclohexyl-1H-pyrrole-2,5-dione","KR_NCIS:
+1H-Pyrrole-2,5-dione, 1-cyclohexyl-; Maleimide, N-cyclohexyl-; N-Cyclohexylmaleimide",1631-25-0,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C1CCC(CC1)N2C(=O)C=CC2=O,https://pubchem.ncbi.nlm.nih.gov/compound/74203,PubChem,O=C1C=CC(=O)N1C1CCCCC1,Train,126,1,testing
+"NZ_CCID:
+Bethoxazin","NZ_CCID:
+3-benzo[b]thien-2-yl-5,6-dihydro-1,4,2-oxathiazine 4-oxide",163269-30-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A66C8578-90D4-48DB-AA61-58EB3C7D0436,"NZ_CCID:
+Skin Irritation
+R-PHRASE: R 38 Irritating to the skin. [Bethoguard Technical MSDS dated Jan 2006]
+Eye Irritation
+R41 - Risk of Serious Damage to eyes
+[Bethoguard Technical MSDS dated Jan 2006]",,NZ_CCID,1,C1CS(=O)C(=NO1)C2=CC3=CC=CC=C3S2,https://pubchem.ncbi.nlm.nih.gov/compound/12040175,PubChem,O=S1CCON=C1c1cc2ccccc2s1,Train,127,1,testing
+"EU_REACH:
+(2S)-2-[(1S,2R,6S,14R,15R,16R)-3-(cyclopropylmethyl)-11,15-dimethoxy-13-oxa-3-azahexacyclo[13.2.2.1²,⁸.0¹,⁶.0⁶,¹⁴.0⁷,¹²]icosa-7,9,11-trien-16-yl]-3,3-dimethylbutan-2-ol",,16524-65-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24919/7/4/2/?documentUUID=66cdde11-6486-4711-a325-dcf65d7cd412,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@]([C@H]1C[C@@]23CC[C@@]1([C@H]4[C@@]25CCN([C@@H]3CC6=C5C(=C(C=C6)OC)O4)CC7CC7)OC)(C(C)(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/14949395,PubChem,COc1ccc2c3c1O[C@H]1[C@@]4(OC)CC[C@@]5(C[C@@H]4[C@](C)(O)C(C)(C)C)[C@@H](C2)N(CC2CC2)CC[C@]315,Train,128,1,testing
+"US_HSDB:
+12-O-TETRADECANOYLPHORBOL-13-ACETATE",,16561-29-8,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/3542,,,US_HSDB,1,CCCCCCCCCCCCCC(=O)O[C@@H]1[C@H]([C@]2([C@@H](C=C(C[C@]3([C@H]2C=C(C3=O)C)O)CO)[C@H]4[C@@]1(C4(C)C)OC(=O)C)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/27924,PubChem,CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)[C@@H](C=C(CO)C[C@]3(O)C(=O)C(C)=C[C@@H]23)[C@@H]2C(C)(C)[C@]12OC(C)=O,Train,129,1,testing
+"EU_REACH:
+(E)-[1-(methylsulfanyl)ethylidene]amino N-methylcarbamate
+
+JP_CHRIP:
+Methomyl","JP_CHRIP:
+Ethanimidothioic acid, N-[[(methylamino)carbonyl]oxy]-, methyl ester
+Ethanimidothioic acid, N-{{(methylamino)carbonyl}oxy}-, methyl ester
+Methomyl
+Methyl N-{(methylamino)carbonyloxy}ethanimidothioate
+S-Methyl N-[(methylcarbamoyl)oxy]thioacetimidate
+S-Methyl-N-(methylcarbamoyloxy)thioacetimidate",16752-77-5,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30946/7/4/2/?documentUUID=9bcc0e07-b791-4676-aa55-4e97a83a2aa9
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0613e.html","EU_REACH:
+Experimental study (OECD TG 404, GLP)
+
+JP_CHRIP:
+Since it was judged to have no stimulativeness in the skin irritation test on rabbits (Agricultural-Chemicals abstracts), it was classified as out of Category.",Provided,"EU_REACH, JP_CHRIP",2,CNC(=O)ON=C(C)SC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.448G,J-GLOBAL,CNC(=O)ON=C(C)SC,Train,130,1,testing
+"US_HSDB:
+Flibanserin",,167933-07-5,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8278,,,US_HSDB,1,C1CN(CCN1CCN2C3=CC=CC=C3NC2=O)C4=CC=CC(=C4)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/6918248,PubChem,O=c1[nH]c2ccccc2n1CCN1CCN(c2cccc(C(F)(F)F)c2)CC1,Train,131,1,testing
+"EU_REACH:
+N,N'-dibutyl-N,N'-bis(1,2,2,6,6-pentamethylpiperidin-4-yl)-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamine",,1702355-94-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18891/7/4/2/?documentUUID=f36e9c5a-0d0e-4819-82d6-57bdaae7e380,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCN(C1CC(N(C(C1)(C)C)C)(C)C)C2=NC(=NC(=N2)N3CCCC3)N(CCCC)C4CC(N(C(C4)(C)C)C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/118030570,PubChem,CCCCN(c1nc(N2CCCC2)nc(N(CCCC)C2CC(C)(C)N(C)C(C)(C)C2)n1)C1CC(C)(C)N(C)C(C)(C)C1,Train,132,1,testing
+"EU_CLP:
+m-mentha-1,3(8)-diene",,17092-80-7,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC1=CC(=C(C)C)CCC1,https://pubchem.ncbi.nlm.nih.gov/compound/524200,PubChem,CC1=CC(=C(C)C)CCC1,Test,133,1,testing
+"EU_REACH:
+1,3-dimethyl 2-[2-(2-amino-6-chloro-9H-purin-9-yl)ethyl]propanedioate",,172529-93-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6816/7/4/2/?documentUUID=f546f617-7201-4855-b3c7-600f7f4b724b,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)C(CCN1C=NC2=C1N=C(N=C2Cl)N)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/9949313,PubChem,COC(=O)C(CCn1cnc2c(Cl)nc(N)nc21)C(=O)OC,Test,134,1,testing
+"NZ_CCID:
+1,2-Dimethylimidazole",,1739-84-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0B3262C0-E0D8-4B84-B5F8-DCD4C617E9A6,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 41 [Company Data]",,NZ_CCID,1,CC1=NC=CN1C,https://pubchem.ncbi.nlm.nih.gov/compound/15617,PubChem,Cc1nccn1C,Train,135,1,testing
+"JP_CHRIP:
+Thiourea dioxide
+
+NZ_CCID:
+Thiourea dioxide","JP_CHRIP:
+amidinosulfinic acid
+thiourea dioxide",1758-73-2,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0156e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/55F76A11-A466-4F33-8D43-0D1593688351","JP_CHRIP:
+Although there are no data available on 4-hour application tests, the substance was moderately irritating to the intact skin and the Draize score was 3.3 in a rabbit 24-hour patch test (SIDS (access on Oct. 2009)) and the substance was classified into Category 2.
+
+NZ_CCID:
+Skin Irritation
+SPECIES: Rabbit
+RESULT: Irritating
+REFERENCE SOURCE: OECW Zweigniederlassung der Degussa Austria GmbH Weissenstein ob der Drau 61Degussa AG, unpublished, report: Degussa AG - US-IT-Nr.: 81-0014-DKT (1981a).
+[IUCLID 2000]
+REMARK: The test material caused moderate irritation of the intact skin and severe irritation of the abraded skin.
+
+Eye Irritation
+SPECIES: Rabbit
+RESULT: Irritating.
+REFERENCE SOURCE: OECW Zweigniederlassung der Degussa Austria GmbH Weissenstein ob der Drau 61Degussa AG, unpublished, report: Degussa AG - US-IT-Nr.:81-0015-DKT (1981b) [IUCLID 2000]",,"JP_CHRIP, NZ_CCID",2,NC(=[S+2]([O-])[O-])N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J57.780D,J-GLOBAL,NC(N)=[S+2]([O-])[O-],Train,136,1,testing
+"NZ_CCID:
+2,3,4,5,6-Pentafluorobenzylbromide",,1765-40-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0EB17F07-2CA6-47F3-AE50-C017C7AB34D7,"NZ_CCID:
+Skin Irritation
+R-PHRASE: R 36/ 37/ 38. [Company data]
+Eye Irritation
+R-PHRASE: R 36/ 37/ 38. [Company data]",,NZ_CCID,1,C(C1=C(C(=C(C(=C1F)F)F)F)F)Br,https://pubchem.ncbi.nlm.nih.gov/compound/74484,PubChem,Fc1c(F)c(F)c(CBr)c(F)c1F,Train,137,1,testing
+"EU_REACH:
+(3S)-5-fluoro-3-methyl-1,3-dihydro-2-benzofuran-1-one",,1803573-19-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18294/7/4/2/?documentUUID=bcb7b050-60c2-4f35-8aa2-d11e0f0d9682,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@H]1C2=C(C=CC(=C2)F)C(=O)O1,https://pubchem.ncbi.nlm.nih.gov/compound/134970125,PubChem,C[C@@H]1OC(=O)c2ccc(F)cc21,Train,138,1,testing
+"EU_REACH:
+tert-butyl N-{5-bromo-3-[(4-methylbenzenesulfonyl)oxy]pyridin-2-yl}-N-[(tert-butoxy)carbonyl]carbamate",,1803573-21-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16687/7/4/2/?documentUUID=3a4422f8-434c-4ae9-88e3-53fdc213f0ef,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)S(=O)(=O)OC2=C(N=CC(=C2)Br)N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/134963154,PubChem,Cc1ccc(S(=O)(=O)Oc2cc(Br)cnc2N(C(=O)OC(C)(C)C)C(=O)OC(C)(C)C)cc1,Train,139,1,testing
+"EU_REACH:
+1,1,2,2,3,3,4,4,5-Nonafluoro-5-(trifluoromethyl)cyclopentane",,1805-22-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24156/7/4/2/?documentUUID=010631c8-2779-4d50-a205-1c985246337c,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1(C(C(C(C1(F)F)(F)F)(F)F)(F)F)(C(F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/74546,PubChem,FC(F)(F)C1(F)C(F)(F)C(F)(F)C(F)(F)C1(F)F,Train,140,3,testing
+"EU_REACH:
+1,1,2,2,3,3,4,5,5,6-decafluoro-4,6-bis(trifluoromethyl)cyclohexane",,335-27-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18928/7/4/2/?documentUUID=5cddc74c-bc1f-4288-850b-80fcd5e886e6,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1(C(C(C(C(C1(F)F)(F)F)(F)F)(C(F)(F)F)F)(F)F)(C(F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/78975,PubChem,FC(F)(F)C1(F)C(F)(F)C(F)(F)C(F)(F)C(F)(C(F)(F)F)C1(F)F,Train,140,3,testing
+"EU_REACH:
+perfluoro(methylcyclohexane)",,355-02-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24227/7/4/2/?documentUUID=0bbe6efe-0f0d-44b7-aae4-303aadbb7658,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1(C(C(C(C(C1(F)F)(F)F)(F)F)(F)F)(F)F)(C(F)(F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/9637,PubChem,FC(F)(F)C1(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C1(F)F,Train,140,3,testing
+"EU_REACH:
+5-[(E)-2-(benzenesulfonyl)ethenyl]-3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-1H-indole",,180637-89-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20535/7/4/2/?documentUUID=a3080f08-ecdb-4dc5-8f55-c2c590221cd0,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN1CCC[C@@H]1CC2=CNC3=C2C=C(C=C3)/C=C/S(=O)(=O)C4=CC=CC=C4,https://pubchem.ncbi.nlm.nih.gov/compound/15840036,PubChem,CN1CCC[C@@H]1Cc1c[nH]c2ccc(/C=C/S(=O)(=O)c3ccccc3)cc12,Train,141,1,testing
+"EU_REACH:
+(14S)-4-bromo-2-methoxy-7-methyl-17-oxa-7-azatetracyclo[12.2.1.0^{5,16}.0^{10,15}]heptadeca-1,3,5(16),10-tetraen-12-one hydrochloride",,183487-56-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25323/7/4/2/?documentUUID=5b836527-99b9-44ae-b6d4-3af3fc62e5d9,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN1CC[C@@]23C=CC(=O)C[C@@H]2OC4=C3C(=C(C=C4OC)Br)C1,https://pubchem.ncbi.nlm.nih.gov/compound/11143024,PubChem,COc1cc(Br)c2c3c1O[C@H]1CC(=O)C=C[C@@]31CCN(C)C2,Train,142,1,testing
+"EU_REACH:
+2-[bis(cyanomethyl)amino]propanenitrile",,185257-07-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2604/7/4/2/?documentUUID=ccdb1309-6fa3-4015-8a92-178c8d6564e7,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C#N)N(CC#N)CC#N,https://pubchem.ncbi.nlm.nih.gov/compound/12040391,PubChem,CC(C#N)N(CC#N)CC#N,Train,143,1,testing
+"EU_REACH:
+2,2-dimethylthiazolidine",,19351-18-9,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22952/7/4/2/?documentUUID=6aec38e4-a043-4145-928a-25d4f25d3f56,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(NCCS1)C,https://pubchem.ncbi.nlm.nih.gov/compound/88015,PubChem,CC1(C)NCCS1,Train,144,1,testing
+"EU_REACH:
+[(1R,2R)-1-methyl-2-{[(1S,3R,5R)-1,2,2-trimethylbicyclo[3.1.0]hexan-3-yl]methyl}cyclopropyl]methanol; [(1S,2S)-1-methyl-2-{[(1S,3R,5R)-1,2,2-trimethylbicyclo[3.1.0]hexan-3-yl]methyl}cyclopropyl]methanol",,198404-98-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29448/7/4/2/?documentUUID=d7ab512a-bdeb-41ce-bb82-bc2ec4b1f1fd,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(C(CC2C1(C2)C)CC3CC3(C)CO)C,https://pubchem.ncbi.nlm.nih.gov/compound/22096564,PubChem,CC1(CO)CC1CC1CC2CC2(C)C1(C)C,Train,145,1,testing
+"EU_REACH:
+2,4,8,10-tetraoxa-3λ⁶,9λ⁶-dithiaspiro[5.5]undecane-3,3,9,9-tetrone",,201419-80-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32238/7/4/2/?documentUUID=ea4db8dd-d0b1-4a81-adda-4f4d04ce450b,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C2(COS(=O)(=O)O1)COS(=O)(=O)OC2,https://pubchem.ncbi.nlm.nih.gov/compound/11311505,PubChem,O=S1(=O)OCC2(CO1)COS(=O)(=O)OC2,Train,146,1,testing
+"EU_REACH:
+flucytosine",,2022-85-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19073/7/4/2/?documentUUID=f7eb1430-03fa-40aa-80a4-80cef4b73a12,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=NC(=O)NC(=C1F)N,https://pubchem.ncbi.nlm.nih.gov/compound/3366,PubChem,Nc1[nH]c(=O)ncc1F,Train,147,1,testing
+"EU_CLP:
+2,2-dichloro-1,3-benzodioxol",,2032-75-9,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1=CC=C2C(=C1)OC(O2)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11041568,PubChem,ClC1(Cl)Oc2ccccc2O1,Test,148,1,testing
+"EU_CLP:
+2-(3,4-dichlorophenyl)-4-methyl-1,2,4-oxadiazolidinedione; methazole",,20354-26-1,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CN1C(=O)N(OC1=O)C2=CC(=C(C=C2)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/4690,PubChem,Cn1c(=O)on(-c2ccc(Cl)c(Cl)c2)c1=O,Test,149,1,testing
+"EU_REACH:
+Ethyl (3aR,7R,7aR)-2,2-dimethyl-7-[(methylsulfonyl)oxy]-3a,6,7,7a-tetrahydro-1,3-benzodioxole-5-carboxylate",,204254-84-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5355/7/4/2/?documentUUID=bffc91b3-ec82-4e36-9042-a4d074c4deff,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1=CC2C(C(C1)OS(=O)(=O)C)OC(O2)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/23565516,PubChem,CCOC(=O)C1=CC2OC(C)(C)OC2C(OS(C)(=O)=O)C1,Train,150,1,testing
+"EU_REACH:
+4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl)-N-(2-ethyl-3-oxo-1,2-oxazolidin-4-yl)-2-methylbenzamide",,2061933-85-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33036/7/4/2/?documentUUID=4156cb2c-d4ad-4f86-bc97-b926ababfe1c,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN1C(=O)C(CO1)NC(=O)C2=C(C=C(C=C2)C3=NOC(C3)(C4=CC(=C(C(=C4)Cl)F)Cl)C(F)(F)F)C,https://pubchem.ncbi.nlm.nih.gov/compound/87323565,PubChem,CCN1OCC(NC(=O)c2ccc(C3=NOC(c4cc(Cl)c(F)c(Cl)c4)(C(F)(F)F)C3)cc2C)C1=O,Train,151,1,testing
+"EU_REACH:
+(5-ethyl-2,2-dimethyl-1,3-dioxan-5-yl)methanol",,20761-68-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23242/7/4/2/?documentUUID=6a00c7ae-fc53-4902-a268-05fdfbeb5bae,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1(COC(OC1)(C)C)CO,https://pubchem.ncbi.nlm.nih.gov/compound/11816152,PubChem,CCC1(CO)COC(C)(C)OC1,Train,152,2,testing
+"EU_REACH:
+(5-ethyl-1,3-dioxan-5-yl)methanol",,5187-23-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11057/7/4/2/?documentUUID=a3ae35d2-c3d8-4d4d-990d-ca71f1b9fcbe,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1(COCOC1)CO,https://pubchem.ncbi.nlm.nih.gov/compound/78860,PubChem,CCC1(CO)COCOC1,Train,152,2,testing
+"NZ_CCID:
+2-(Hydroxymethyl)-N-methylpiperidine","NZ_CCID:
+1-methyl-2-piperidinemethanol",20845-34-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D34626DC-88BC-4774-A785-BDB193003F24,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CN1CCCCC1CO,https://pubchem.ncbi.nlm.nih.gov/compound/89394,PubChem,CN1CCCCC1CO,Train,153,1,testing
+"EU_REACH:
+1-(2-ethylbutyl)cyclohexanecarbonyl chloride",,211515-46-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22233/7/4/2/?documentUUID=c63c2c5c-65fa-4b07-9f14-6d24bd33e111,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(CC)CC1(CCCCC1)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10657125,PubChem,CCC(CC)CC1(C(=O)Cl)CCCCC1,Train,154,2,testing
+"EU_REACH:
+1-(2-ethylbutyl)cyclohexane-1-carboxylic acid",,381209-09-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22242/7/4/2/?documentUUID=67da2f1a-8633-4c56-b78f-fc0878427c79,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC(CC)CC1(CCCCC1)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/10488751,PubChem,CCC(CC)CC1(C(=O)O)CCCCC1,Test,154,2,testing
+"NZ_CCID:
+Dimethylallylamine","NZ_CCID:
+N,N-Dimethylallylamine",2155-94-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CE2F1C68-0C0E-49A3-B08C-60935AE1D9C1,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CN(C)CC=C,https://pubchem.ncbi.nlm.nih.gov/compound/75082,PubChem,C=CCN(C)C,Train,155,1,testing
+"JP_CHRIP:
+2-[(Thiocyanatomethyl)sulfanyl]-1,3-benzothiazole
+
+NZ_CCID:
+2-(Thiocyanomethylthio) benzothiazole","JP_CHRIP:
+(2-Benzothiazolylthio)methyl thiocyanate
+2-(thiocyanatomethylthio)benzothiazole
+TCMTB
+Thiocyanic acid, 2-(benzothiazolylthio)methyl ester
+
+NZ_CCID:
+Thiocyanic acid, (2-benzothiazolylthio)methyl ester, TCMTB",21564-17-0,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2092e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D43DE403-6A2B-4494-988F-462EE7DBC972","JP_CHRIP:
+[Rationale for the Classification]
+Based on (1) and (2), it was classified in Category 2.
+
+[Evidence Data]
+(1) In a skin irritation test in which this substance (active ingredient: 80%) was applied to rabbits in compliance with EPA OPPTS 870.2500, the Primary Irritation Index (PIS) was 7.42, and severe erythema and edema were observed after 72 hours (EPA Pesticide (2006), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2010)).
+(2) In a skin irritation test with rabbits, severe skin irritation was observed (Hazard Assessment Report (CERI, NITE, 2008)).
+
+[Reference Data, etc.]
+(3) It was classified as ""Skin Irrit. 2 (H315)"" in the EU CLP classification (EU CLP classification (Access on September 2019)).
+
+NZ_CCID:
+Skin Irritation
+SPECIES:
+RESULT: The substance irritates the skin.
+REFERENCE SOURCE: (2-(THIOCYANOMETHYLTHIO)BENZOTHIAZOLE ICSC: 1161 April 1997) [INCHEM]
+Eye Irritation
+SPECIES:
+RESULT: The substance...is corrosive to the eyes.
+REFERENCE SOURCE: (2-(THIOCYANOMETHYLTHIO)BENZOTHIAZOLE ICSC: 1161 April 1997) [INCHEM]",,"JP_CHRIP, NZ_CCID",2,N#CSCSc1nc2ccccc2s1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J10.910J,J-GLOBAL,N#CSCSc1nc2ccccc2s1,Train,156,1,testing
+"EU_REACH:
+3,​3,​5,​7,​7-​pentamethyl-1,2,4-trioxepane",,215877-64-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/3940/7/4/2/?documentUUID=9fc0c6b9-221f-49dc-b8c3-95212fd40b73,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1CC(OOC(O1)(C)C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11019359,PubChem,CC1CC(C)(C)OOC(C)(C)O1,Train,157,1,testing
+"JP_CHRIP:
+3-Cyclohexyl-5,6-trimethyleneuracil; Lenacil",,2164-08-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-0008e.html,"JP_CHRIP:
+[Rationale for the Classification]
+Based on (1) and (2), it was classified as ""Not classified.""
+
+[Evidence Data]
+(1) In a skin irritation test (equivalent to OECD TG 404, GLP) with rabbits (n=3, female), since both mean scores of erythema and edema were 0 at 24/48/72 hours, it was judged to be non-irritating to the skin (CLH Report (2013)).
+(2) This substance is not irritating to the skin (PATTY (6th, 2012)).",Provided,JP_CHRIP,1,O=c1[nH]c2CCCc2c(=O)n1C1CCCCC1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.387A,J-GLOBAL,O=c1[nH]c2c(c(=O)n1C1CCCCC1)CCC2,Train,158,1,testing
+"JP_CHRIP:
+3,4-Dichloro-N-(2-cyanophenyl)isothiazole-5-carboxamide; Isotianil",,224049-04-1,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0043e.html,"JP_CHRIP:
+[Rationale for the Classification]
+It was classified as ""Not classified"" from (1).
+
+[Evidence Data]
+(1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 72-hour observation), no irritation changes were seen (erythema/eschar score: 0/0/0, edema score: 0/0/0) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009), REACH registration dossier (Accessed Sep. 2020), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)).",Provided,JP_CHRIP,1,Clc1nsc(C(=O)Nc2ccccc2C#N)c1Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.510.822A,J-GLOBAL,N#Cc1ccccc1NC(=O)c1snc(Cl)c1Cl,Train,159,1,testing
+"EU_CLP:
+4,4,5,5-tetrachloro-1,3-dioxolan-2-one",,22432-68-4,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1(=O)OC(C(O1)(Cl)Cl)(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/2724978,PubChem,O=C1OC(Cl)(Cl)C(Cl)(Cl)O1,Test,160,1,testing
+"JP_CHRIP:
+di-allate (ISO); S-(2,3-dichloroallyl)-N,N-diisopropylthiocarbamate","JP_CHRIP:
+Diallate",2303-16-4,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0129e.html,"JP_CHRIP:
+Since it was documented that in a test using rabbits, the substance is a moderate irritant to the skin (EHC 76 (1988): The pesticide manual: world compendium, 7th ed., Croydon, British Crop Protection Council), and also in human exposure, its irritation was suggested (HSFS (2004), HSDB (2003)), the substance was classified into Category 2.",,JP_CHRIP,1,CC(C)N(C(C)C)C(=O)SCC(=CCl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.705B,J-GLOBAL,CC(C)N(C(=O)SCC(Cl)=CCl)C(C)C,Train,161,1,testing
+"EU_REACH:
+2,2,2-trifluoro-1-{5,8,14-triazatetracyclo[10.3.1.0²,¹¹.0⁴,⁹]hexadeca-2,4,6,8,10-pentaen-14-yl}ethan-1-one",,230615-70-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21699/7/4/2/?documentUUID=ceb47fba-3fc1-4856-b331-7cc8f0c2e658,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C2CN(CC1C3=CC4=NC=CN=C4C=C23)C(=O)C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/11483621,PubChem,O=C(N1CC2CC(C1)c1cc3nccnc3cc12)C(F)(F)F,Train,162,1,testing
+"JP_CHRIP:
+O,O-Diethyl S-(6-chloro-2,3-dihydro-2-oxobenzoxazolinyl)methyl phosphorodithioate; Phosalone","JP_CHRIP:
+Benzphos
+O,O-Diethyl S-(6-chloro-2,3-dihydro-2-oxobenzoxazolinyl)methyl phosphorodithioate
+Phosphorodithioic acid, S-[(6-chloro-2-oxo-3(2H)-benzoxazolyl)methyl] O,O-diethyl ester
+S-6-chloro-2,3-dihydro-2-oxobenzoxazol-3-ylmethyl O,O-diethyl phosphorodithioate",2310-17-0,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2055e.html,"JP_CHRIP:
+[Rationale for the Classification]
+It was classified in Category 2 from (1).
+
+[Evidence Data]
+(1) This substance was moderately irritating to the skin and eyes (HSDB (Access on May 2020)).",,JP_CHRIP,1,CCOP(=S)(OCC)SCn1c2ccc(Cl)cc2oc1=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.146F,J-GLOBAL,CCOP(=S)(OCC)SCn1c(=O)oc2cc(Cl)ccc21,Train,163,1,testing
+"JP_CHRIP:
+2-(4-tert-butylphenoxy)cyclohexyl 2-propynyl sulfite; Propargite
+
+KR_NCIS:
+Propargite
+
+NZ_CCID:
+Propargite","JP_CHRIP:
+2-(4-tert-Butylphenoxy)cyclohexyl 2-propynyl sulfite
+
+KR_NCIS:
+2-(4-tert-Butylphenoxy)-cyclohexyl prop-2-ynyl sulfite",2312-35-8,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2068e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C6F31D3A-E426-465E-8888-2F2CF19FE0BA","JP_CHRIP:
+[Rationale for the Classification]
+It was classified in Category 2 from (1), (2).
+
+[Evidence Data]
+(1) This substance was irritating to the rabbit skin (JMPR (1999), EU REACH CoRAP (2019), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2012), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2011)).
+(2) Skin illness and eye irritation were reported in incident cases of workers who used this substance (HSDB (Access on May 2020)).
+
+[Reference Data, etc.]
+(3) In a skin irritation test with rabbits on Omite Technical (effective concentration of this substance 57%) according to EPA OPPTS 870.2500, it was judged as a corrosive substance (EPA Pesticides RED (2001)).
+(4) It was classified in Skin Irrit. 2 (H315) in EU-CLP classification (EU CLP classification (Access on August 2020)).
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [ECB Working database]
+Eye Irritation
+R PHRASE: R 41 [ECB Working database]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,CC(C)(C)c1ccc(OC2CCCCC2OS(=O)OCC#C)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.805H,J-GLOBAL,C#CCOS(=O)OC1CCCCC1Oc1ccc(C(C)(C)C)cc1,Train,164,1,testing
+"EU_REACH:
+2-{1-oxa-4-azaspiro[4.5]decan-4-yl}ethan-1-ol",,2359-11-7,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16434/7/4/2/?documentUUID=89c647ce-cbbc-4f0d-92f3-36a986d7c4a5,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CCC2(CC1)N(CCO2)CCO,https://pubchem.ncbi.nlm.nih.gov/compound/75380,PubChem,OCCN1CCOC12CCCCC2,Train,165,1,testing
+"EU_REACH:
+2,4,6,8-tetramethyl-1,3,5,7,2,4,6,8-tetroxatetrasilocane",,2370-88-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15844/7/4/2/?documentUUID=1bf574cd-9386-45d7-9a64-b5f82d51a10c,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si]1O[Si](O[Si](O[Si](O1)C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6327421,PubChem,C[Si]1O[Si](C)O[Si](C)O[Si](C)O1,Train,166,2,testing
+"EU_REACH:
+2,4,6,8,10-pentamethyl-1,3,5,7,9,2,4,6,8,10-pentaoxapentasilecane",,6166-86-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15795/7/4/2/?documentUUID=5919d62b-529c-4390-9f20-0c9adff8db23,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si]1O[Si](O[Si](O[Si](O[Si](O1)C)C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6327588,PubChem,C[Si]1O[Si](C)O[Si](C)O[Si](C)O[Si](C)O1,Train,166,2,testing
+"EU_REACH:
+2,4,6-trimethyl-2,4,6-tris(3,3,3-trifluoropropyl)cyclotrisiloxane",,2374-14-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13466/7/4/2/?documentUUID=64f04cc9-ac0b-4b85-88bc-aa84648e171c,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si]1(O[Si](O[Si](O1)(C)CCC(F)(F)F)(C)CCC(F)(F)F)CCC(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/75410,PubChem,C[Si]1(CCC(F)(F)F)O[Si](C)(CCC(F)(F)F)O[Si](C)(CCC(F)(F)F)O1,Train,167,1,testing
+"EU_REACH:
+7-methyl-3,4-dihydro-2H-1,3-benzoxazine-2,4-dione",,24088-77-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10884/7/4/2/?documentUUID=fe35ee98-60e0-4d2f-ab85-54db84097352,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC2=C(C=C1)C(=O)NC(=O)O2,https://pubchem.ncbi.nlm.nih.gov/compound/11550082,PubChem,Cc1ccc2c(=O)[nH]c(=O)oc2c1,Train,168,3,testing
+"EU_REACH:
+2,9-dichloro-5,7,12,14-tetrahydro-5,12-diazapentacene-7,14-dione",,3089-17-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14471/7/4/2/?documentUUID=fb5f5603-0eae-479c-a577-140dc15c671c,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=C(C=C1Cl)C(=O)C3=CC4=C(C=C3N2)C(=O)C5=C(N4)C=CC(=C5)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/76530,PubChem,O=c1c2cc(Cl)ccc2[nH]c2cc3c(=O)c4cc(Cl)ccc4[nH]c3cc12,Train,168,3,testing
+"EU_REACH:
+2,9-dimethyl-5,7,12,14-tetrahydro-5,12-diazapentacene-7,14-dione",,980-26-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15097/7/4/2/?documentUUID=aabf1b39-4487-4c50-b208-f10146622530,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC2=C(C=C1)NC3=CC4=C(C=C3C2=O)NC5=C(C4=O)C=C(C=C5)C,https://pubchem.ncbi.nlm.nih.gov/compound/70423,PubChem,Cc1ccc2[nH]c3cc4c(=O)c5cc(C)ccc5[nH]c4cc3c(=O)c2c1,Train,168,3,testing
+"JP_CHRIP:
+(N-(1,1,2,2-Tetrachloroethylthio)-1,2,3,6-tetrahydrophthalimide); Captafol","JP_CHRIP:
+3a,4,7,7a-Tetrahydro-N-(1,1,2,2-tetrachloroethanesulphenyl)phthalimide
+Captafol
+Difolatan (R)
+N-(1,1,2,2-Tetrachloroethylthio)-1,2,3,6-tetrahydrophthalimide
+N-(1,1,2,2-Tetrachloroethylthio)cyclohex-4-ene-1,2-dicarboximide",2425-06-1,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0826e.html,"JP_CHRIP:
+It was set as Category 2 by description that there was moderate irritation to the skin of the rabbit (ACGIH (7th, 2001)), and by description that many stimulative and allergic examples of contact dermatitis development of symptoms were reported in the agriculture and forestry pursuers of handling KYAPUTAFORU in Kumamoto, other domestic areas, and New Zealand (PIM 097 (1990), ACGIH (7th, 2001)).",,JP_CHRIP,1,ClC(Cl)C(Cl)(Cl)SN1C(=O)C2CC=CCC2C1=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.026K,J-GLOBAL,O=C1C2CC=CCC2C(=O)N1SC(Cl)(Cl)C(Cl)Cl,Train,169,1,testing
+"EU_REACH:
+6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid",,24280-93-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15977/7/4/2/?documentUUID=9cc5ab29-6b54-4594-ba05-d021f4f26fd7,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C2COC(=O)C2=C(C(=C1OC)C/C=C(\C)/CCC(=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/446541,PubChem,COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(=O)O)C(=O)OC2,Train,170,1,testing
+"EU_REACH:
+2,6-diethyl-2,3,6-trimethyl-1-(1-phenylethoxy)piperidin-4-one",,244021-01-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17025/7/4/2/?documentUUID=ee396b4c-82e9-48e4-bfa4-1467b89cdfd0,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1(CC(=O)C(C(N1OC(C)C2=CC=CC=C2)(C)CC)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/22341848,PubChem,CCC1(C)CC(=O)C(C)C(C)(CC)N1OC(C)c1ccccc1,Train,171,1,testing
+"EU_REACH:
+944-817-9",,244626-73-1,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19586/7/4/2/?documentUUID=5855ddb3-4e1e-46e6-a89c-694834bf9000,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CCC(C1(C)C)/C=C/C(C)(C)C(C)O,https://pubchem.ncbi.nlm.nih.gov/compound/15984303,PubChem,CC1=CCC(/C=C/C(C)(C)C(C)O)C1(C)C,Train,172,2,testing
+"EU_REACH:
+(R)-2,2,3-trimethylcyclopent-3-ene-1-acetaldehyde",,4501-58-0,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5954/7/4/2/?documentUUID=fc440949-4e98-435d-a4f7-5ec8a1cdba27,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC[C@@H](C1(C)C)CC=O,https://pubchem.ncbi.nlm.nih.gov/compound/1252759,PubChem,CC1=CC[C@H](CC=O)C1(C)C,Test,172,2,testing
+"EU_REACH:
+(6R,7R)-7-amino-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid",,24701-69-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2446/7/4/2/?documentUUID=5d5d9d52-5e8a-4d05-b9bf-1d3b540b9e51,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COCC1=C(N2[C@@H]([C@@H](C2=O)N)SC1)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/9816277,PubChem,COCC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1,Test,173,2,testing
+"EU_REACH:
+7-amino-3-{[(2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid",,58909-56-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25483/7/4/2/?documentUUID=d3645584-42ae-4024-9598-e6d0452b13eb,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN1C(=NC(=O)C(=O)N1)SCC2=C(N3[C@@H]([C@@H](C3=O)N)SC2)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/6351062,PubChem,Cn1[nH]c(=O)c(=O)nc1SCC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1,Train,173,2,testing
+"EU_REACH:
+5-methyl-s-triazolo[1,5-a]pyrimidin-7-ol",,2503-56-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21778/7/4/2/?documentUUID=1bccd83d-6270-4016-8b2a-88a984890b08,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC(=O)N2C(=N1)N=CN2,https://pubchem.ncbi.nlm.nih.gov/compound/75629,PubChem,Cc1cc(=O)n2[nH]cnc2n1,Train,174,1,testing
+"NZ_CCID:
+Clobetasol propionate",,25122-46-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/80D24C8B-2A1B-416E-9A39-F5D016E5360C,"NZ_CCID:
+Skin Irritation
+REMARK: Confidential information supplied by registrant
+Eye Irritation
+REMARK: Confidential information supplied by registrant",,NZ_CCID,1,CCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/32798,PubChem,CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C,Train,175,3,testing
+"NZ_CCID:
+Beclomethasone dipropionate",,5534-09-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C12484FF-265E-48FB-9ABB-48BBE250C10E,"NZ_CCID:
+Skin Irritation
+REMARK: Confidential information supplied by registrant
+Eye Irritation
+REMARK: Confidential information supplied by registrant",,NZ_CCID,1,CCC(=O)OCC(=O)[C@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)Cl)O)C)C)OC(=O)CC,https://pubchem.ncbi.nlm.nih.gov/compound/21700,PubChem,CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@@]21C,Train,175,3,testing
+"NZ_CCID:
+Fluticasone propionate",,80474-14-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/19093C3C-5C29-425B-8A62-F039B2F23289,"NZ_CCID:
+Skin Irritation
+EXPERT JUDGEMENT: Classification based a weight of evidence review of company MSDS
+Eye Irritation
+EXPERT JUDGEMENT: Classification based a weight of evidence review of company MSDS",,NZ_CCID,1,CCC(=O)O[C@@]1([C@@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2C[C@@H](C4=CC(=O)C=C[C@@]43C)F)F)O)C)C)C(=O)SCF,https://pubchem.ncbi.nlm.nih.gov/compound/444036,PubChem,CCC(=O)O[C@]1(C(=O)SCF)[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C,Train,175,3,testing
+"EU_REACH:
+quinuclidin-3-ol",,25333-42-0,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25385/7/4/2/?documentUUID=d427dccb-cd32-406e-b270-fe959c49a1c3,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CN2CCC1[C@H](C2)O,https://pubchem.ncbi.nlm.nih.gov/compound/91404,PubChem,O[C@H]1CN2CCC1CC2,Train,176,1,testing
+"JP_CHRIP:
+Hexabromocyclododecane","JP_CHRIP:
+cyclododecane, hexabromo
+Cyclododecane, hexabromo-; Cyclododecane,hexabromo-; Hexabromocyclododecane
+Cyclododecane, hexabromo-isomers",25637-99-4,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0013e.html,"JP_CHRIP:
+In a skin irritation study using rabbits (OECD TG 404), very slight erythema was observed, but the irritation was concluded to be negative (EU-RAR (2008), NICNAS (2012)). Therefore, the substance was classified as ""Not classified.""",Provided,JP_CHRIP,1,BrC1(Br)C(Br)(Br)C(Br)(Br)CCCCCCCCC1,https://www.nite.go.jp/en/chem/chrip/chrip_search/cmpInfDsp?cid=C004-784-59A&slScNm=CI_01_001&bcPtn=3,CHRIP,BrC1(Br)CCCCCCCCCC(Br)(Br)C1(Br)Br,Train,177,1,testing
+"EU_REACH:
+3,4-dihydro-2H-1,4-benzoxazin-6-ol",,26021-57-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32979/7/4/2/?documentUUID=99e9b8a2-44f8-4e1b-9fb9-b7fea55c1e52,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1COC2=C(N1)C=C(C=C2)O,https://pubchem.ncbi.nlm.nih.gov/compound/117709,PubChem,Oc1ccc2c(c1)NCCO2,Train,178,1,testing
+"EU_REACH:
+(1E)-1-(methoxyimino)-1-(2,5,5-trimethyl-1,3-dioxan-2-yl)acetone",,263355-39-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6388/7/4/2/?documentUUID=4d45c9f9-fd50-40e5-9049-61917fbd4b16,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)/C(=N\OC)/C1(OCC(CO1)(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/88152585,PubChem,CO/N=C(\C(C)=O)C1(C)OCC(C)(C)CO1,Train,179,1,testing
+"EU_REACH:
+[(1,3-thiazolidin-2-ylidene)amino]formonitrile",,26364-65-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/3973/7/4/2/?documentUUID=09398107-f635-4c8d-acb8-7c10353592df,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CSC(=N1)NC#N,https://pubchem.ncbi.nlm.nih.gov/compound/3700797,PubChem,N#CNC1=NCCS1,Train,180,1,testing
+"NZ_CCID:
+Isoflurane",,26675-46-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C3CF899C-2E32-4A37-9F66-ACA997B2794D,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38. [http://physchem.ox.ac.uk/MSDS/IS/isoflurane.html]
+Eye Irritation
+R PHRASE: R 36. [http://physchem.ox.ac.uk/MSDS/IS/isoflurane.html]",,NZ_CCID,1,C(C(F)(F)F)(OC(F)F)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/3763,PubChem,FC(F)OC(Cl)C(F)(F)F,Train,181,1,testing
+"EU_CLP:
+9-(2-propenyloxy)tricyclo[5.2.1.0(2,6)]dec-3(or-4-)-ene",,26912-64-1,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C=CCOC1CC2CC1C3C2CC=C3,https://pubchem.ncbi.nlm.nih.gov/compound/102779,PubChem,C=CCOC1CC2CC1C1C=CCC21,Test,182,1,testing
+"JP_CHRIP:
+N-[4-(1,1,1,2,3,3,3-Heptafluoropropan-2-yl)-2-methylphenyl]-3-iodo-N'-[2-methyl-1-(methylsulfonyl)propan-2-yl]phthalamide; Flubendiamide","JP_CHRIP:
+3-Iodo-N2-[2-methyl-1-(methylsulfonyl)propan-2-yl]-N1-[2-methyl-4-(perfluoropropan-2-yl)phenyl]phthalamide",272451-65-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0077e.html,"JP_CHRIP:
+[Rationale for the Classification]
+It was classified as ""Not classified"" from (1).
+
+[Evidence Data]
+(1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 72-hour observation), no irritation changes were seen in any animal (erythema/eschar score: 0/0/0, edema score: 0/0/0) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2019), JMPR (2010), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2015)).",Provided,JP_CHRIP,1,Cc1cc(ccc1NC(=O)c1cccc(I)c1C(=O)NC(C)(C)CS(=O)(=O)C)C(F)(C(F)(F)F)C(F)(F)F,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.180.104F,J-GLOBAL,Cc1cc(C(F)(C(F)(F)F)C(F)(F)F)ccc1NC(=O)c1cccc(I)c1C(=O)NC(C)(C)CS(C)(=O)=O,Train,183,1,testing
+"US_HSDB:
+Ticagrelor",,274693-27-5,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8306,,,US_HSDB,1,CCCSC1=NC(=C2C(=N1)N(N=N2)[C@@H]3C[C@@H]([C@H]([C@H]3O)O)OCCO)N[C@@H]4C[C@H]4C5=CC(=C(C=C5)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/9871419,PubChem,CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(F)c(F)c2)c2nnn([C@@H]3C[C@H](OCCO)[C@@H](O)[C@H]3O)c2n1,Train,184,1,testing
+"NZ_CCID:
+Diquat",,2764-72-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2EB9DDEF-9794-4352-89F2-A1ABE89017E9,"NZ_CCID:
+Skin Irritation
+SPECIES:
+RESULT:
+Skin Irritation, epistaxis, nail damage, and delayed wound healing have been reported.
+REFERENCE SOURCE: Diquat: Health & Safety Guide 52,http://www.inchem.org/documents/hsg/hsg/hsg052.htm
+
+Eye Irritation
+SPECIES: Rat/ Dog
+RESULT: Development of eye cataracts has been reported in rats and dogs following long-term treatment with diquat.
+REFERENCE SOURCE: [Diquat: Health & Safety Guide 52,http://www.inchem.org/documents/hsg/hsg/hsg052.htm]",,NZ_CCID,1,C1C[N+]2=CC=CC=C2C3=CC=CC=[N+]31,https://pubchem.ncbi.nlm.nih.gov/compound/6795,PubChem,c1cc[n+]2c(c1)-c1cccc[n+]1CC2,Train,185,1,testing
+"JP_CHRIP:
+Triethylenediamine
+
+NZ_CCID:
+1,4-Diazabicyclo[2.2.2]octane","JP_CHRIP:
+1,4-diazabicyclo[2.2.2]octane
+
+NZ_CCID:
+1,4-DIAZABICYCLOOCTANE, 1,4-ETHYLENEPIPERAZINE, DABCO, TED, TRIETHYLENEDIAMINE",280-57-9,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0178e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2DA6CC26-8A09-44BB-92C8-6EEBCDE87ABC","JP_CHRIP:
+The substance was classified as Category 2 based on the document that the primary dermal irritation index (PDII) was 4.05 in the rabbit Draize test (SIDS (2005)).
+
+NZ_CCID:
+Skin Irritation
+SPECIES: Rabbit
+RESULT: Irritating
+REFERENCE SOURCE: Mortensen B, Nordic chemicals group. Nord Vol: 6 (1992) pp 99-108 [TOXLINE]
+Eye Irritation
+SPECIES: Rabbit
+RESULT: Severe burning
+REFERENCE SOURCE: Mortensen B, Nordic chemicals group, Nord Vol: 6 (1992) pp 99-108 [TOXLINE]",,"JP_CHRIP, NZ_CCID",2,C1CN2CCN1CC2,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.451H,J-GLOBAL,C1CN2CCN1CC2,Train,186,1,testing
+"EU_CLP:
+5-ethoxy-5H-furan-2-one",,2833-30-9,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCOC1C=CC(=O)O1,https://pubchem.ncbi.nlm.nih.gov/compound/3293575,PubChem,CCOC1C=CC(=O)O1,Test,187,1,testing
+"EU_REACH:
+(2,5-dimethyl-2,3-dihydro-1H-inden-2-yl)methanol",,285977-85-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/28258/7/4/2/?documentUUID=bf5dc3f3-c61e-499e-a7db-a83f1d0b3d0c,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC2=C(CC(C2)(C)CO)C=C1,https://pubchem.ncbi.nlm.nih.gov/compound/11367306,PubChem,Cc1ccc2c(c1)CC(C)(CO)C2,Train,188,1,testing
+"NZ_CCID:
+Pyrazole",,288-13-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EBA0D0A4-CC38-4EC8-A4DF-C5BA901DF1B8,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CNN=C1,https://pubchem.ncbi.nlm.nih.gov/compound/1048,PubChem,c1cn[nH]c1,Train,189,1,testing
+"AU_HCIS:
+imidazole
+
+JP_CHRIP:
+Imidazole
+
+NZ_CCID:
+Imidazole
+
+US_HSDB:
+Imidazole","AU_HCIS:
+1H-Imidazole
+
+JP_CHRIP:
+1,3-Diaza-2,4-cyclopentadiene
+1,3-Diazole
+Glyoxaline
+Imidazole
+Miazole",288-32-4,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5703
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0012e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/62CEC8DD-C50A-4A76-8B08-68C06132EBDF
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8449","JP_CHRIP:
+In a test in which 0.5 mL of paste-like test substance containing 80% of this substance and water was applied to the rabbit skin for 4 hours, severe erythema developed overnight and persisted by day 8 after the observation period, slight necrosis appeared overnight, and necrosis in all layers was pathologically observed after the observation period. As a result, this substance was assessed to be corrosive (SIDS (2004)). Therefore, it was classified in Category 1.
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,"AU_HCIS, JP_CHRIP, NZ_CCID, US_HSDB",4,c1c[nH]cn1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.566F,J-GLOBAL,c1c[nH]cn1,Train,190,1,testing
+"NZ_CCID:
+Butanediamide, 2,3-dihydroxy-N,N'-di-2-propenyl-",,28843-34-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A6CF4E34-5160-4178-83BD-0A3919EB8C29,"NZ_CCID:
+Skin Irritation
+R-PHRASE: R 36/37/38 Irritating to eyes, respiratory system and skin.
+Eye Irritation
+R-PHRASE: R 36/37/38 Irritating to eyes, respiratory system and skin.",,NZ_CCID,1,C=CCNC(=O)C(C(C(=O)NCC=C)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/98486,PubChem,C=CCNC(=O)C(O)C(O)C(=O)NCC=C,Train,191,1,testing
+"NZ_CCID:
+1,2-Dihydroxy-3,4-cyclobutenedione","NZ_CCID:
+3,4-dihydroxy-3-cyclobutene-1,2-dione",2892-51-5,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DAE4919D-DA08-4675-9F81-C07719F069A6,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1(=C(C(=O)C1=O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/17913,PubChem,O=c1c(O)c(O)c1=O,Train,192,1,testing
+"EU_REACH:
+(2-amino-1,3-thiazol-4-yl)acetic acid",,29676-71-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22991/7/4/2/?documentUUID=7e6c6021-8602-431a-835b-07d99aced2a5,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=C(N=C(S1)N)CC(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/34665,PubChem,Nc1nc(CC(=O)O)cs1,Train,193,1,testing
+"NZ_CCID:
+1,5-Diazabicyclo(4.3.0)non-5-ene","NZ_CCID:
+1,5-diazabicyclo[4.3.0]non-5-ene",3001-72-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C5B1E1AC-9C9D-40B1-9841-E9DDB1E04F7A,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CC2=NCCCN2C1,https://pubchem.ncbi.nlm.nih.gov/compound/76349,PubChem,C1CN=C2CCCN2C1,Train,194,2,testing
+"NZ_CCID:
+1,8-Diazabicyclo[5.4.0]undec-7-ene",,6674-22-2,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2FD4F486-BD79-4972-870D-99C7ED29853F,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C1CCC2=NCCCN2CC1,https://pubchem.ncbi.nlm.nih.gov/compound/81184,PubChem,C1CCC2=NCCCN2CC1,Train,194,2,testing
+"EU_CLP:
+chloral hydrate; 2,2,2-trichloroethane-1,1-diol",,302-17-0,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C(C(Cl)(Cl)Cl)(O)O,https://pubchem.ncbi.nlm.nih.gov/compound/2707,PubChem,OC(O)C(Cl)(Cl)Cl,Test,195,1,testing
+"EU_REACH:
+2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide",,302964-08-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20338/7/4/2/?documentUUID=c263e08a-037e-48e5-b3ef-b166a36fb205,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11269410,PubChem,Cc1nc(Cl)cc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)n1,Test,196,1,testing
+"EU_REACH:
+octadecafluoro-decahydronaphthalene",,306-94-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25306/7/4/2/?documentUUID=65827910-d3ec-4784-bdf1-e5b816940368,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C12(C(C(C(C(C1(F)F)(F)F)(F)F)(F)F)(C(C(C(C2(F)F)(F)F)(F)F)(F)F)F)F,https://pubchem.ncbi.nlm.nih.gov/compound/9386,PubChem,FC1(F)C(F)(F)C(F)(F)C2(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C2(F)C1(F)F,Train,197,1,testing
+"EU_REACH:
+(1R,2S,3S,6R,7S)-tricyclo[5.2.1.0²,⁶]decane-3-carbaldehyde; bis((1R,2S,4R,6R,7S)-tricyclo[5.2.1.0²,⁶]decane-4-carbaldehyde)",,30772-79-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17510/7/4/2/?documentUUID=3b0d87bb-8f1c-486a-891b-043b451f144f,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,O=CC1CCC2C3CCC(C3)C12,https://cactus.nci.nih.gov/chemical/structure/30772-79-3/smiles,CACTUS,O=CC1CCC2C3CCC(C3)C12,Train,198,1,testing
+"US_HSDB:
+Dicloxacillin",,3116-76-5,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/3222,,,US_HSDB,1,CC1=C(C(=NO1)C2=C(C=CC=C2Cl)Cl)C(=O)N[C@H]3[C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/18381,PubChem,Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)N[C@@H]1C(=O)N2[C@@H]1SC(C)(C)[C@@H]2C(=O)O,Train,199,2,testing
+"NZ_CCID:
+Ampicillin",,69-53-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/160AED2D-D153-48BE-99E6-812A6DFC4532,"NZ_CCID:
+Skin Irritation
+R-PHRASES: R38. [http://www.sigmaaldrich.com/cgi-bin/hsrun/Suite7/Suite/HAHTpage/Suite.HsAdvancedSearch.formAction]
+Eye Irritation
+R-PHRASES: R 36. [http://www.sigmaaldrich.com/cgi-bin/hsrun/Suite7/Suite/HAHTpage/Suite.HsAdvancedSearch.formAction]",,NZ_CCID,1,CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)N)C(=O)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/6249,PubChem,CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C(=O)O,Train,199,2,testing
+"EU_REACH:
+5-bromo-3-sec-butyl-6-methylpyrimidine-2,4(1H,3H)-dione
+
+JP_CHRIP:
+5-Bromo-3-sec-butyl-6-methyl uracil; Bromacil","JP_CHRIP:
+2,4(1H,3H)-Pyrimidinedione, 5-bromo-6-methyl-3-(1-methyl propyl)-
+5-Bromo-3-sec-butyl-6-methyl uracil
+5-Bromo-3-sec-butyl-6-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
+5-Bromo-6-methyl-3-(1-methylpropyl) uracil
+5-Bromo-6-methyl-3-(1-methylpropyl)-2,4(1H,3H)-pyrimidinedione
+Bromacil",314-40-9,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26639/7/4/2/?documentUUID=84e63bb9-601e-4306-acd9-c5be8eb0d34b
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2104e.html","EU_REACH:
+Experimental study (OECD TG 404, GLP)
+
+JP_CHRIP:
+[Rationale for the Classification]
+It was classified as ""Not classified"" (corresponding to Category 3 in UN GHS classification) from (1) - (3).
+
+[Evidence Data]
+(1) It was reported to be not irritating in a skin irritation test with rabbits according to OECD TG 404 (REACH registration dossier (Access on September 2020)).
+(2) In a skin irritation test with rabbits according to EPA OPP 81-5, the primary irritation score was 0.8, and it was classified in Category IV (no irritation or slight erythema seen at 72 hours after application) (EPA Pesticides RED (1996)).
+(3) In a skin irritation test with rabbits, no irritation was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2016)).",Provided,"EU_REACH, JP_CHRIP",2,CCC(C)n1c(=O)[nH]c(C)c(Br)c1=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J8.594D,J-GLOBAL,CCC(C)n1c(=O)[nH]c(C)c(Br)c1=O,Train,200,1,testing
+"NZ_CCID:
+(1S)-(+)-Camphor-10-sulphonic acid",,3144-16-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/912701A9-9463-43E4-9AA8-28F84F53D953,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC1([C@@H]2CC[C@]1(C(=O)C2)CS(=O)(=O)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/65617,PubChem,CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)O)C(=O)C2,Train,201,3,testing
+"NZ_CCID:
+(1R)-(-)-Camphor-10-sulphonic acid chloride",,39262-22-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/22B35975-C77B-4682-8035-58571384EA79,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CC1([C@H]2CC[C@@]1(C(=O)C2)CS(=O)(=O)Cl)C,https://pubchem.ncbi.nlm.nih.gov/compound/9816396,PubChem,CC1(C)[C@H]2CC[C@]1(CS(=O)(=O)Cl)C(=O)C2,Train,201,3,testing
+"JP_CHRIP:
+bornan-2-one
+
+US_HSDB:
+CAMPHOR","JP_CHRIP:
+1,7,7-Trimethylbicyclo(2.2.1)heptan-2-one
+2-Bornanone
+2-Camphanone
+Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-
+Camphor
+DL-camphor",76-22-2,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0797e.html
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/37","JP_CHRIP:
+It was classified as Category 2 from the statement that it caused two burns in exposure of 4 hours (infant) - 50 hours to the gauze containing camphor (HSDB (2005)).",,"JP_CHRIP, US_HSDB",2,CC1(C)C2CCC1(C)C(=O)C2,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.364H,J-GLOBAL,CC12CCC(CC1=O)C2(C)C,Train,201,3,testing
+"NZ_CCID:
+(4R,5R)-(-)-4,5-Bis(diphenylphosphinomethyl)-2,2-dimethyl -1,3-dioxolane",,32305-98-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/08C864F0-C004-4F5F-A670-59E05FC0D0AA,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1(O[C@H]([C@@H](O1)CP(C2=CC=CC=C2)C3=CC=CC=C3)CP(C4=CC=CC=C4)C5=CC=CC=C5)C,https://pubchem.ncbi.nlm.nih.gov/compound/395120,PubChem,CC1(C)O[C@@H](CP(c2ccccc2)c2ccccc2)[C@H](CP(c2ccccc2)c2ccccc2)O1,Train,202,1,testing
+"EU_REACH:
+(3S,5S)-5-[(1S,3S)-1-azido-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl]-3-(propan-2-yl)oxolan-2-one",,324763-46-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5295/7/4/2/?documentUUID=aa358301-705c-44d2-8e2b-76191c77d85e,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)[C@@H]1C[C@H](OC1=O)[C@H](C[C@H](CC2=CC(=C(C=C2)OC)OCCCOC)C(C)C)N=[N+]=[N-],https://pubchem.ncbi.nlm.nih.gov/compound/11775573,PubChem,COCCCOc1cc(C[C@@H](C[C@H](N=[N+]=[N-])[C@@H]2C[C@@H](C(C)C)C(=O)O2)C(C)C)ccc1OC,Train,203,1,testing
+"NZ_CCID:
+Chloromethyl thiocyanate",,3268-79-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/34683A06-AFFB-401C-8D8B-B0B4DD9C52AB,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(SC#N)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/76755,PubChem,N#CSCCl,Train,204,2,testing
+"EU_CLP:
+methylene dithiocyanate",,6317-18-6,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C(SC#N)SC#N,https://pubchem.ncbi.nlm.nih.gov/compound/22772,PubChem,N#CSCSC#N,Test,204,2,testing
+"EU_REACH:
+1,1,3,3-tetramethyldisiloxane",,3277-26-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14225/7/4/2/?documentUUID=d65d74a2-8d43-4558-845c-a9810cc4f95a,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si](C)O[Si](C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6327482,PubChem,C[Si](C)O[Si](C)C,Train,205,1,testing
+"JP_CHRIP:
+2,3-dicyano-1,4-dithiaanthraquinone; Dithianon","JP_CHRIP:
+2,3-dicyano-1,4-dithia-anthraquinone [synonym:Dithianon]
+2,3-Dicyano-1,4-dithiaanthraquinone
+5,10-dioxo-5,10-dihydronaphtho[2,3-b][1,4]dithiine-2,3-dicarbonitrile (synonym:2,3-dicyano-1,4-dithia-anthraquinone or dithianon)",3347-22-6,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2072e.html,"JP_CHRIP:
+[Rationale for the Classification]
+It was classified as ""Not classified"" from (1) - (4).
+
+[Evidence Data]
+(1) In a skin irritation test with rabbits on this substance according to OECD TG 404 (4-hour occlusive application), it was not irritating (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)).
+(2) This substance was not irritating in a skin irritation test with rabbits (4-hour occlusive application) (JMPR (2010)).
+(3) This substance was not irritating to the rabbit skin (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018)).
+(4) This substance was not irritating in a skin irritation test with rabbits (24-hour occlusive application) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012), Agricultural Chemicals Times supplement ""Agricultural chemicals technology information"" No. 9 (Japan Crop Protection Association, 1991)).
+
+[Reference Data, etc.]
+(5) This substance may cause severe skin irritation in sensitive individuals (HSDB (Access on May 2020)).",Provided,JP_CHRIP,1,O=c1c2ccccc2c(=O)c2=c1sc(c(s2)C#N)C#N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.516K,J-GLOBAL,N#Cc1sc2c(=O)c3ccccc3c(=O)c=2sc1C#N,Train,206,1,testing
+"JP_CHRIP:
+diazomethane","JP_CHRIP:
+Azimethylene
+Diazirine
+Methane, diazo-",334-88-3,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0740e.html,"JP_CHRIP:
+It was classified as Category 2 as it was reported that there is stimulativeness and denudation on human skin (ACGIH (2001)).",,JP_CHRIP,1,C=[N+]=[N-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.576C,J-GLOBAL,C=[N+]=[N-],Train,207,1,testing
+"AU_HCIS:
+4H-Inden-4-one, 1,2,3,5,6,7-hexahydro-1,1,2,3,3-pentamethyl-",,33704-61-9,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6617,,,AU_HCIS,1,CC1C(C2=C(C1(C)C)C(=O)CCC2)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/92292,PubChem,CC1C(C)(C)C2=C(C(=O)CCC2)C1(C)C,Train,208,1,testing
+"EU_CLP:
+3,3,4,4-tetrafluoro-4-iodo-1-butene",,33831-83-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C=CC(C(F)(F)I)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/118555,PubChem,C=CC(F)(F)C(F)(F)I,Test,209,1,testing
+"EU_REACH:
+2,5-anhydro-4-{[4-(4-{4-[({1-[(2S,3S)-2-(benzyloxy)pentan-3-yl]hydrazino}carbonyl)amino]phenyl}piperazin1-yl)phenoxy]methyl}-1,3,4-trideoxy-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-",,345217-03-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18670/7/4/2/?documentUUID=4c164cfe-3ebc-426b-9dc7-7af92362d490,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC[C@@H]([C@H](C)OCC1=CC=CC=C1)N(C(=O)NC2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5C[C@](OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F)N,https://pubchem.ncbi.nlm.nih.gov/compound/165364850,PubChem,CC[C@@H]([C@H](C)OCc1ccccc1)N(N)C(=O)Nc1ccc(N2CCN(c3ccc(OC[C@@H]4CO[C@@](Cn5cncn5)(c5ccc(F)cc5F)C4)cc3)CC2)cc1,Train,210,1,testing
+"NZ_CCID:
+1,4-Dithiothreitol
+
+US_HSDB:
+1,4-Dithiothreitol",,3483-12-3,Cat 2,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B43637B5-BE5D-4545-8932-2EBCE8492A1F
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8422","NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,"NZ_CCID, US_HSDB",2,C(C(C(CS)O)O)S,https://pubchem.ncbi.nlm.nih.gov/compound/19001,PubChem,OC(CS)C(O)CS,Train,211,2,testing
+"NZ_CCID:
+2,3-Dimercapto-1-propanol","NZ_CCID:
+dimercaprol",59-52-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2F06288C-C747-425D-98B3-F283A649AEB4,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C(C(CS)S)O,https://pubchem.ncbi.nlm.nih.gov/compound/3080,PubChem,OCC(S)CS,Train,211,2,testing
+"EU_REACH:
+2-[2-(dimethylamino)ethoxy]ethyl N-{[1,3,3-trimethyl-5-(9-methyl-2-oxo-3,6-dioxa-1,9-diazadecan-1-yl)cyclohexyl]methyl}carbamate",,351197-46-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12553/7/4/2/?documentUUID=69ac8112-39d1-471c-bd93-a260ffd4d8cf,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(CC(CC(C1)(C)CNC(=O)OCCOCCN(C)C)NC(=O)OCCOCCN(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/53424022,PubChem,CN(C)CCOCCOC(=O)NCC1(C)CC(NC(=O)OCCOCCN(C)C)CC(C)(C)C1,Train,212,3,testing
+"EU_REACH:
+Urea,N'-[3-[[[(dimethylamino)carbonyl]amino]methyl]-3,5,5-trimethylcyclohexyl]-N,N-dimethyl-",,39992-90-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21212/7/4/2/?documentUUID=8a510312-5192-476b-b735-d7a1ff7d8ae6,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(CC(CC(C1)(C)CNC(=O)N(C)C)NC(=O)N(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/21155941,PubChem,CN(C)C(=O)NCC1(C)CC(NC(=O)N(C)C)CC(C)(C)C1,Train,212,3,testing
+"EU_REACH:
+3-[(3-{[(2-cyanoethyl)amino]methyl}-3,5,5-trimethylcyclohexyl)amino]propanenitrile",,93940-97-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27660/7/4/2/?documentUUID=74ba3518-30f8-4abc-8531-4cca642df503,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(CC(CC(C1)(C)CNCCC#N)NCCC#N)C,https://pubchem.ncbi.nlm.nih.gov/compound/3022992,PubChem,CC1(C)CC(NCCC#N)CC(C)(CNCCC#N)C1,Train,212,3,testing
+"EU_REACH:
+(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl methanesulfonate",,35130-97-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1387/7/4/2/?documentUUID=1d632d16-7df3-4d96-baf2-a409cae30185,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN1[C@@H]2CC[C@H]1CC(C2)OS(=O)(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/16125705,PubChem,CN1[C@@H]2CC[C@H]1CC(OS(C)(=O)=O)C2,Train,213,1,testing
+"NZ_CCID:
+Norgestimate",,35189-28-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AB0C09AF-0699-452D-B642-018AE29F1683,"NZ_CCID:
+Skin Irritation
+REMARK: Confidential information supplied by registrant
+Eye Irritation
+REMARK: Confidential information supplied by registrant",,NZ_CCID,1,CC[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)OC(=O)C)CCC4=CC(=NO)CC[C@H]34,https://pubchem.ncbi.nlm.nih.gov/compound/37083,PubChem,C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=NO)CC[C@@H]4[C@H]3CC[C@@]21CC,Train,214,1,testing
+"EU_REACH:
+10-[4-(2-chloroethyl)piperazin-1-yl]-2-thia-9-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaene",,352232-17-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24114/7/4/2/?documentUUID=56e004c0-afcd-40e0-a8dd-2865790fc52e,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CN(CCN1)C2=NC3=CC=CC=C3SC4=C(C=CC=C42)CCCl,https://pubchem.ncbi.nlm.nih.gov/compound/57349184,PubChem,ClCCc1cccc2c1Sc1ccccc1N=C2N1CCNCC1,Train,215,1,testing
+"EU_REACH:
+5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid",,35453-19-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5239/7/4/2/?documentUUID=77bc7fbf-f772-48a7-bb7b-82e348742fde,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1(=C(C(=C(C(=C1I)N)I)C(=O)O)I)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/3015783,PubChem,Nc1c(I)c(C(=O)O)c(I)c(C(=O)O)c1I,Train,216,2,testing
+"EU_REACH:
+5-amino-2,4,6-triiodobenzene-1,3-dicarbonyl dichloride",,37441-29-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12669/7/4/2/?documentUUID=e9e655b2-bb0b-4d42-803e-567ca7c9d80c,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1(=C(C(=C(C(=C1I)N)I)C(=O)Cl)I)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/9894858,PubChem,Nc1c(I)c(C(=O)Cl)c(I)c(C(=O)Cl)c1I,Train,216,2,testing
+"JP_CHRIP:
+imazalil (ISO); 1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole","JP_CHRIP:
+1-(2-(2,4-Dichlorophenyl)-2-(2-propenyloxy)ethyl)-1H-imidazole
+1-[2-(Allyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole (synonym:imazalil)
+Allyl 1-(2,4-dichlorophenyl)-2-imidazol-1-ylethyl ether
+Enilconazole",35554-44-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0268e.html,"JP_CHRIP:
+In Draize tests using rabbits, mild skin irritation was detected (JMPR No. 12, 2005). However, in different tests using rabbits (OECD TG 404), erythema or oedema was not observed, and the substance was found to not be an irritant (JMPR No. 8 (2000)). In addition, in skin irritation tests involving several volunteers, no symptoms such as burning, itching or pain were detected (JMPR No. 8 (2000)). Based on these documents, the substance was classified into ""Not classified"".",Provided,JP_CHRIP,1,Clc1ccc(C(Cn2ccnc2)OCC=C)c(Cl)c1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J21.235K,J-GLOBAL,C=CCOC(Cn1ccnc1)c1ccc(Cl)cc1Cl,Train,217,1,testing
+"EU_REACH:
+6H-dibenz[c,e][1,2]oxaphosphorin 6-oxide",,35948-25-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5483/7/4/2/?documentUUID=7c6c3a1d-6fc1-4239-9407-24560709b328,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C3=CC=CC=C3[P+](=O)O2,https://pubchem.ncbi.nlm.nih.gov/compound/6328250,PubChem,O=[p+]1oc2ccccc2c2ccccc21,Train,218,1,testing
+"EU_REACH:
+(2S)-2-{[(tert-butoxy)carbonyl]amino}-2-(3-hydroxyadamantan-1-yl)acetic acid",,361442-00-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13388/7/4/2/?documentUUID=fd45cd9c-00e4-4f29-ab7f-a90d99e1365b,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)OC(=O)N[C@H](C(=O)O)C12CC3CC(C1)CC(C3)(C2)O,https://pubchem.ncbi.nlm.nih.gov/compound/11723843,PubChem,CC(C)(C)OC(=O)N[C@H](C(=O)O)C12CC3CC(CC(O)(C3)C1)C2,Train,219,1,testing
+"JP_CHRIP:
+3-Bromo-2,2-bis(bromomethyl)propan-1-ol","JP_CHRIP:
+Tribromoneopentyl alcohol",36483-57-5,NC,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-mhlw-0003.html,"JP_CHRIP:
+【分類根拠】
+（１）より、区分に該当しない。
+
+【根拠データ】
+（１）ウサギ（n = 3）を用いた皮膚刺激性試験（OECD TG 404、半閉塞、4時間適用、72時間観察）において、皮膚刺激性はみられなかった（紅斑・痂皮スコア：0/0/0、浮腫スコア：0/0/0）との報告がある（REACH登録情報 (Accessed Sep. 2021)）。",Provided,JP_CHRIP,1,OCC(CBr)(CBr)CBr,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J111.581B,J-GLOBAL,OCC(CBr)(CBr)CBr,Train,220,1,testing
+"EU_REACH:
+7,7,8,9,9-pentamethyl-2H,4H,4aH,5H,6H,7H,8H,9H,9bH-indeno[4,5-d][1,3]dioxine",,365411-50-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11467/7/4/2/?documentUUID=6c3d18c1-04fa-4a48-b153-dac6962bea8f,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1C(C2=C(C1(C)C)C3C(CC2)COCO3)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/15552386,PubChem,CC1C(C)(C)C2=C(C3OCOCC3CC2)C1(C)C,Train,221,1,testing
+"EU_REACH:
+7-[2-(2-hydroxymethylethoxy)methylethoxy]tetramethyl-3,6,8,11-tetraoxa-7-phosphatridecane-1,13-diol",,36788-39-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5793/7/4/2/?documentUUID=3354e0cd-ac3c-4bc5-85b6-c68fc393ff80,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(COCCCO)OP(OCCOCCO)OCCOC(C)(C)C(C)(C)O,https://pubchem.ncbi.nlm.nih.gov/compound/169815,PubChem,CC(COCCCO)OP(OCCOCCO)OCCOC(C)(C)C(C)(C)O,Train,222,1,testing
+"EU_REACH:
+5,5'-(1H-isoindole-1,3(2H)-diylidene)dipyrimidine-2,4,6(1H,3H,5H)-trione",,36888-99-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13313/7/4/2/?documentUUID=30b1e191-a3d8-4b50-9af4-78f9d2e80f26,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C(=C3C(=O)NC(=O)NC3=O)N=C2C4=C(NC(=O)NC4=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/160357,PubChem,O=C1NC(=O)C(=C2N=C(c3c(O)[nH]c(=O)[nH]c3=O)c3ccccc32)C(=O)N1,Train,223,1,testing
+"EU_REACH:
+(3aR,5aS,9aS,9bR)-3a,6,6,9a-tetramethyl-dodecahydronaphtho[2,1-b]furan; (3aR,5aS,9aS,9bS)-3a,6,6,9a-tetramethyl-dodecahydronaphtho[2,1-b]furan; (3aS,5aR,9aR,9bR)-3a,6,6,9a-tetramethyl-dodecahydronaphtho[2,1-b]furan; (3aS,5aR,9aR,9bS)-3a,6,6,9a-tetramethyl-dodecahydronaphtho[2,1-b]furan",,3738-00-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16416/7/4/2/?documentUUID=33f28e6d-64b5-416f-8c32-784c24f0068e,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(CCCC2(C1CCC3(C2CCO3)C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/107166,PubChem,CC1(C)CCCC2(C)C1CCC1(C)OCCC12,Train,224,2,testing
+"EU_REACH:
+5,5,9,13-tetramethyl-14,16-dioxatetracyclo[11.2.1.0¹,¹⁰.0⁴,⁹]hexadecane",,57345-19-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21986/7/4/2/?documentUUID=263413d0-5b79-4d7b-a366-15bd8bbfbd2f,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(CCCC2(C1CCC34C2CCC(O3)(OC4)C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/93639,PubChem,CC12CCC3C(CCC4C(C)(C)CCCC43C)(CO1)O2,Train,224,2,testing
+"EU_REACH:
+[(4-{6-tert-butyl-7-chloro-1H-pyrazolo[1,5-b][1,2,4]triazol-2-yl}phenyl)carbamoyl]methyl 2-hexyldecanoate",,379268-96-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/3405/7/4/2/?documentUUID=48d32d91-a4ca-4d37-ae69-dd526db201c0,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCCCCC(CCCCCC)C(=O)OCC(=O)NC1=CC=C(C=C1)C2=NN3C(=N2)C(=C(N3)C(C)(C)C)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/58800829,PubChem,CCCCCCCCC(CCCCCC)C(=O)OCC(=O)Nc1ccc(-c2nc3c(Cl)c(C(C)(C)C)[nH]n3n2)cc1,Train,225,1,testing
+"EU_REACH:
+Glycine, N-acetyl-N-[3-(trifluoromethyl)phenyl]valyl-, ethyl ester",,379685-94-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25397/7/4/2/?documentUUID=ddb9923b-293b-4f46-9f0d-d433d5c9f8b1,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CNC(=O)C(C(C)C)N(C1=CC=CC(=C1)C(F)(F)F)C(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/10178334,PubChem,CCOC(=O)CNC(=O)C(C(C)C)N(C(C)=O)c1cccc(C(F)(F)F)c1,Train,226,1,testing
+"NZ_CCID:
+Diethylaminosulphur trifluoride",,38078-09-0,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DFF17B20-BB23-455A-B10A-5FEE26BCF8CE,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 35 [Company Data]
+Eye Irritation
+R PHRASE: R 35 [Company Data]",,NZ_CCID,1,CCN(CC)S(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/123472,PubChem,CCN(CC)S(F)(F)F,Train,227,1,testing
+"EU_REACH:
+2-[difluoro(methoxy)methyl]-1,1,1,3,3,3-hexafluoropropane",,382-26-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7493/7/4/2/?documentUUID=beff31ec-7dd2-4b30-9b91-273c7d6a2786,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(C(C(F)(F)F)C(F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/45459,PubChem,COC(F)(F)C(C(F)(F)F)C(F)(F)F,Train,228,1,testing
+"EU_REACH:
+2,2,3,3,5,5,6,6-octafluoro-4-(trifluoromethyl)morpholine",,382-28-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10245/7/4/2/?documentUUID=9ba97411-2f32-4e82-81f6-f2d088f97f5c,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1(C(OC(C(N1C(F)(F)F)(F)F)(F)F)(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/67839,PubChem,FC(F)(F)N1C(F)(F)C(F)(F)OC(F)(F)C1(F)F,Train,229,1,testing
+"NZ_CCID:
+Minoxidil",,38304-91-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7260A362-5A28-4634-864B-0A7D6B7B238D,"NZ_CCID:
+Skin Irritation
+REMARK: Confidential information supplied by registrant
+Eye Irritation
+REMARK: Confidential information supplied by registrant",,NZ_CCID,1,C1CCN(CC1)C2=NC(=N)N(C(=C2)N)O,https://pubchem.ncbi.nlm.nih.gov/compound/4201,PubChem,N=c1nc(N2CCCCC2)cc(N)n1O,Train,230,1,testing
+"EU_REACH:
+3-[(2,2-Dimethyl-1,2-azasilolidin-1-yl)(dimethyl)silyl]-1-propanamine",,388606-32-4,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/4257/7/4/2/?documentUUID=da260297-58f0-4939-8a4e-7dab7d6686b2,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si]1(CCCN1[Si](C)(C)CCCN)C,https://pubchem.ncbi.nlm.nih.gov/compound/11817097,PubChem,C[Si](C)(CCCN)N1CCC[Si]1(C)C,Test,231,1,testing
+"AU_HCIS:
+Urea, N,N''-methylenebis[N'-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-",,39236-46-9,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5043,,,AU_HCIS,1,C(NC(=O)NC1C(=O)NC(=O)N1CO)NC(=O)NC2C(=O)NC(=O)N2CO,https://pubchem.ncbi.nlm.nih.gov/compound/38258,PubChem,O=C(NCNC(=O)NC1C(=O)NC(=O)N1CO)NC1C(=O)NC(=O)N1CO,Train,232,1,testing
+"EU_REACH:
+4-(p-chlorophenyl)piperidin-4-ol",,39512-49-7,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20416/7/4/2/?documentUUID=5f5556bb-da68-4d4c-8e20-38526e3e1818,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CNCCC1(C2=CC=C(C=C2)Cl)O,https://pubchem.ncbi.nlm.nih.gov/compound/38282,PubChem,OC1(c2ccc(Cl)cc2)CCNCC1,Train,233,2,testing
+"EU_REACH:
+4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide",,53179-11-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18180/7/4/2/?documentUUID=5e38ccb6-fb1d-446f-99c7-fc7b158a2784,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4,https://pubchem.ncbi.nlm.nih.gov/compound/3955,PubChem,CN(C)C(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1,Test,233,2,testing
+"NZ_CCID:
+Triamterene
+
+US_HSDB:
+Triamterene",,396-01-0,Cat 2,"NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1B6FDDBC-87A8-4314-83EB-CEEF6DB4A3D7
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/3405","NZ_CCID:
+Skin Irritation
+REMARK: Confidential information supplied by registrant.
+Eye Irritation
+REMARK: Confidential information supplied by registrant.",,"NZ_CCID, US_HSDB",2,C1=CC=C(C=C1)C2=NC3=C(N=C(N=C3N=C2N)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/5546,PubChem,Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1,Train,234,1,testing
+"NZ_CCID:
+(IS)-(-) Camphonic acid chloride",,39637-74-6,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1B2D5C75-B1B2-48D0-83FB-A116BFD64D88,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [CHEMWATCH]
+Eye Irritation
+R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C[C@@]12CC[C@@](C1(C)C)(OC2=O)C(=O)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/170232,PubChem,CC1(C)[C@@]2(C)CC[C@]1(C(=O)Cl)OC2=O,Train,235,1,testing
+"KR_NCIS:
+Ethylene phosphorodifluoridite",,3965-00-2,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C(COP(F)F)OP(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/23234030,PubChem,FP(F)OCCOP(F)F,Train,236,1,testing
+"EU_REACH:
+1,4-dithiane-2,5-diol",,40018-26-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19050/7/4/2/?documentUUID=53d479d9-90c8-4ab8-ad94-778043422a06,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C(SCC(S1)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/98330,PubChem,OC1CSC(O)CS1,Train,237,1,testing
+"JP_CHRIP:
+2-Methoxyethyl 2-[4-(tert-butyl)phenyl]-2-cyano-3-oxo-3-[2-(trifluoromethyl)phenyl]propanoate; Cyflumetofen",,400882-07-7,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0050e.html,"JP_CHRIP:
+[Rationale for the Classification]
+It was classified as ""Not classified"" from (1), (2).
+
+[Evidence Data]
+(1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 72-hour observation), no skin irritation reactions were observed in any animal (erythema/eschar score: 0/0/0, edema score: 0/0/0) (ECHA RAC Opinion (2017), CLH Report (2016)).
+(2) It is reported that in a skin irritation test with rabbits (n = 3) (GLP, semi-occlusive, 4-hour application, 72-hour observation), no skin irritation reactions were seen in any animal (erythema/eschar score: 0/0/0, edema score: 0/0/0) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2017)).",Provided,JP_CHRIP,1,COCCOC(=O)C(C#N)(C(=O)c1ccccc1C(F)(F)F)c1ccc(cc1)C(C)(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.193.546H,J-GLOBAL,COCCOC(=O)C(C#N)(C(=O)c1ccccc1C(F)(F)F)c1ccc(C(C)(C)C)cc1,Train,238,1,testing
+"EU_REACH:
+1,1,2,2-tetrafluoro-1-(2,2,2-trifluoroethoxy)ethane",,406-78-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30633/7/4/2/?documentUUID=bbfdc696-7f65-46e1-b9e8-e632583d6351,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C(C(F)(F)F)OC(C(F)F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/164596,PubChem,FC(F)C(F)(F)OCC(F)(F)F,Train,239,1,testing
+"EU_REACH:
+3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one",,41078-70-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25825/7/4/2/?documentUUID=6c1cc7af-e86d-4e6d-884e-99f6f46bedf5,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C(=O)N2C=CC=CC2=N1)CCCl,https://pubchem.ncbi.nlm.nih.gov/compound/817866,PubChem,Cc1nc2ccccn2c(=O)c1CCCl,Train,240,1,testing
+"ChemSkin:
+4-Acetoxy-2,5-dimethyl-3(2H)-furanone (2,5-dimethyl-4-oxo-4,5-dihydrofuran-3-yl acetate)",,4166-20-5,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
+Experimental study (OECD TG 404)",Provided,ChemSkin,1,CC1C(=O)C(=C(O1)C)OC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/61334,PubChem,CC(=O)OC1=C(C)OC(C)C1=O,Test,241,1,testing
+"EU_REACH:
+1-Methyl-3-nitro-guanidine",,4245-76-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/9150/7/4/2/?documentUUID=fa290fa0-bab1-4c60-98ad-a06237d7246f,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CN=C(N)N[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/20237,PubChem,CN=C(N)N[N+](=O)[O-],Train,242,2,testing
+"EU_CLP:
+1-methyl-3-nitro-1-nitrosoguanidine",,70-25-7,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CN(C(=N)N[N+](=O)[O-])N=O,https://pubchem.ncbi.nlm.nih.gov/compound/135436526,PubChem,CN(N=O)C(=N)N[N+](=O)[O-],Test,242,2,testing
+"NZ_CCID:
+Cyproterone acetate",,427-51-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BB01F1FB-D4CD-4DC3-A7D6-17741706F157,"NZ_CCID:
+Skin Irritation
+REMARK: Confidential information supplied by registrant.
+Eye Irritation
+REMARK: Confidential information supplied by registrant.",,NZ_CCID,1,CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C=C(C4=CC(=O)[C@@H]5C[C@@H]5[C@]34C)Cl)C)OC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/9880,PubChem,CC(=O)O[C@]1(C(C)=O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C,Train,243,1,testing
+"EU_REACH:
+(2S,3S,3aR,9aS)-3-hydroxy-2-(hydroxymethyl)-7-methyl-2,3,3a,9a-tertryhydro-6H-furo[2’,3’:4,5][1,3]oxazolo [3,2-a]pyrimidin-6-one",,433733-92-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/3994/7/4/2/?documentUUID=ea7aecbf-6e3f-4f88-9444-0b054deba8a0,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CN2[C@@H]3[C@H]([C@H]([C@@H](O3)CO)O)OC2=NC1=O,https://pubchem.ncbi.nlm.nih.gov/compound/90472642,PubChem,Cc1cn2c(nc1=O)O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]12,Train,244,3,testing
+"EU_REACH:
+[(2S,3R,5S)-3-acetoxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl acetate",,433733-94-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11709/7/4/2/?documentUUID=59fd471b-a191-427a-aecd-36debed1e6f6,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CN(C(=O)NC1=O)[C@@H]2C[C@H]([C@@H](O2)COC(=O)C)OC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/12065176,PubChem,CC(=O)OC[C@@H]1O[C@H](n2cc(C)c(=O)[nH]c2=O)C[C@H]1OC(C)=O,Train,244,3,testing
+"EU_REACH:
+thymidine",,50-89-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15994/7/4/2/?documentUUID=4bbeefa5-dcb1-4856-98cb-8e45ffc90b81,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O,https://pubchem.ncbi.nlm.nih.gov/compound/5789,PubChem,Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O,Train,244,3,testing
+"NZ_CCID:
+Glyoxal trimeric, dihydrate, >10% in a non hazardous diluent",,4405-13-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/93A479FE-81DE-4BE3-8DBD-686C909E4244,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 36 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1(C(OC2C(O1)OC(C(O2)O)O)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/92988,PubChem,OC1OC2OC(O)C(O)OC2OC1O,Train,245,1,testing
+"EU_REACH:
+bisbenzimidazo[2,1-b:2',1'-i]benzo[lmn][3,8]phenanthroline-8,17-dione",,4424-06-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18833/7/4/2/?documentUUID=2bd387d8-9055-41ed-9037-04198a0a8ea3,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)N=C3N2C(=O)C4=CC=C5C6=C(C=CC3=C46)C(=O)N7C5=NC8=CC=CC=C87,https://pubchem.ncbi.nlm.nih.gov/compound/78141,PubChem,O=c1c2ccc3c4c(ccc(c24)c2nc4ccccc4n12)c(=O)n1c2ccccc2nc31,Train,246,3,testing
+"EU_REACH:
+17-(3-methoxypropyl)-6(or7)-methyl-3,10,17-triazahexacyclo[13.6.2.0²,¹.0,.0¹²,²².0¹,²³]tricosa-1(21),2,4(9),5,7,12(22),13,15(23),19-nonaene-11,16,18-trione",,52673-15-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20656/7/4/2/?documentUUID=baff9584-b6ed-4e76-b5d3-8bed09262776,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC2=C(C=C1)N3C(=N2)C4=C5C(=CC=C6C5=C(C=C4)C(=O)N(C6=O)CCCOC)C3=O,https://pubchem.ncbi.nlm.nih.gov/compound/104284,PubChem,COCCCN1C(=O)c2ccc3c(=O)n4c5ccc(C)cc5nc4c4ccc(c2c34)C1=O,Train,246,3,testing
+"EU_REACH:
+14H-benz[4,5]isoquino[2,1-a]perimidin-14-one",,6829-22-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21766/7/4/2/?documentUUID=2356744d-187e-4cf9-b4e0-bd5d1e035100,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC2=C3C(=C1)C4=NC5=CC=CC6=C5C(=CC=C6)N4C(=O)C3=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/81271,PubChem,O=c1c2cccc3cccc(c32)c2nc3cccc4cccc(c43)n12,Train,246,3,testing
+"ChemSkin:
+Tetrabromophenol blue",,4430-25-5,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
+Experimental study (OECD TG 404)",Provided,ChemSkin,1,C1=C(C=C(C(=C1Br)O)Br)C2(C3=C(C(=C(C(=C3Br)Br)Br)Br)S(=O)(=O)O2)C4=CC(=C(C(=C4)Br)O)Br,https://pubchem.ncbi.nlm.nih.gov/compound/78159,PubChem,O=S1(=O)OC(c2cc(Br)c(O)c(Br)c2)(c2cc(Br)c(O)c(Br)c2)c2c(Br)c(Br)c(Br)c(Br)c21,Test,247,1,testing
+"EU_REACH:
+2,6-di-tert-butyl-4-methylcyclohexyl 5-{[bis(2-ethoxy-2-oxoethyl)carbamoyl]oxy}-2-(4-tert-butylphenyl)-6-cyano-1H-pyrrolo[1,2-b][1,2,4]triazole-7-carboxylate",,444065-11-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6359/7/4/2/?documentUUID=0e9d481f-e5c8-4eb0-a775-4ecbd9869c97,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CN(CC(=O)OCC)C(=O)OC1=C(C(=C2N1NC(=N2)C3=CC=C(C=C3)C(C)(C)C)C(=O)OC4C(CC(CC4C(C)(C)C)C)C(C)(C)C)C#N,https://pubchem.ncbi.nlm.nih.gov/compound/70903663,PubChem,CCOC(=O)CN(CC(=O)OCC)C(=O)Oc1c(C#N)c(C(=O)OC2C(C(C)(C)C)CC(C)CC2C(C)(C)C)c2nc(-c3ccc(C(C)(C)C)cc3)[nH]n12,Train,248,1,testing
+"NZ_CCID:
+Azathioprine",,446-86-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C3B175B4-2228-4FE2-B4BA-5123CBF209C7,"NZ_CCID:
+Skin Irritation
+REMARK: Confidential information supplied by registrant.
+Eye Irritation
+REMARK: Confidential information supplied by registrant.",,NZ_CCID,1,CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/2265,PubChem,Cn1cnc([N+](=O)[O-])c1Sc1ncnc2nc[nH]c12,Train,249,1,testing
+"EU_REACH:
+[(2R,3R,4R,5S,6S)-3,4,5-tris(acetyloxy)-6-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}oxan-2-yl]methyl acetate",,461432-25-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5228/7/4/2/?documentUUID=b2791948-46e1-4d9c-90a2-a87b3bc814f4,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)COC(=O)C)OC(=O)C)OC(=O)C)OC(=O)C)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/10415783,PubChem,CCOc1ccc(Cc2cc([C@@H]3O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(C)=O)ccc2Cl)cc1,Train,250,3,testing
+"EU_REACH:
+[(2R,3R,4R,5S,6S)-3,4,5-tris(acetyloxy)-6-(3-{[5-(4-fluorophenyl)thiophen-2-yl]methyl}-4-methylphenyl)oxan-2-yl]methyl acetate",,866607-35-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30373/7/4/2/?documentUUID=ad783eea-1de3-4f27-b407-aa326147fcc5,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)COC(=O)C)OC(=O)C)OC(=O)C)OC(=O)C)CC3=CC=C(S3)C4=CC=C(C=C4)F,https://pubchem.ncbi.nlm.nih.gov/compound/25224976,PubChem,CC(=O)OC[C@H]1O[C@@H](c2ccc(C)c(Cc3ccc(-c4ccc(F)cc4)s3)c2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O,Train,250,3,testing
+"EU_REACH:
+2-(4-fluorophenyl)-5-(5-iodo-2-methylbenzyl)thiophene",,898566-17-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27058/7/4/2/?documentUUID=9c4813d4-5f39-40c5-a422-19bc624986f7,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C(C=C(C=C1)I)CC2=CC=C(S2)C3=CC=C(C=C3)F,https://pubchem.ncbi.nlm.nih.gov/compound/45789954,PubChem,Cc1ccc(I)cc1Cc1ccc(-c2ccc(F)cc2)s1,Train,250,3,testing
+"EU_REACH:
+trifluoro(oxolan-1-ium-1-yl)boranuide",,462-34-0,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11415/7/4/2/?documentUUID=bee13733-38ca-4eea-9a61-f7dfb9951245,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,[B-]([O+]1CCCC1)(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/60146129,PubChem,F[B-](F)(F)[O+]1CCCC1,Test,251,1,testing
+"JP_CHRIP:
+Ketene","JP_CHRIP:
+Carbomethene
+Ethenone
+Ketoethylene",463-51-4,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0710e.html,"JP_CHRIP:
+It was classified as Category 2 based on the statement that redness arises with severe irritation on humans (ICSC (J) (1997), HSDB (2005)).",,JP_CHRIP,1,C=C=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.590I,J-GLOBAL,C=C=O,Train,252,1,testing
+"NZ_CCID:
+Eucalyptol",,470-82-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1F7D0AA2-5FA8-421E-A2C2-DF67EB12B270,"NZ_CCID:
+Skin Irritation
+Classification based on the pure chemical classification and mixture rules.
+Eye Irritation
+Classification based on the pure chemical classification and mixture rules.",,NZ_CCID,1,CC1(C2CCC(O1)(CC2)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/2758,PubChem,CC12CCC(CC1)C(C)(C)O2,Train,253,1,testing
+"EU_REACH:
+2-{2-chloro-4-(methylsulfonyl)-3-[(tetrahydrofuran-2-ylmethoxy)methyl]benzoyl}cyclohexane-1,3-dione
+
+JP_CHRIP:
+2-{2-Chloro-4-(methylsulfonyl)-3-[(oxolan-2-ylmethoxy)methyl]benzoyl}cyclohexane-1,3-dione; Tefuryltrione",,473278-76-1,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22220/7/4/2/?documentUUID=88ad67cb-7599-4755-9352-7547bd783f79
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0042e.html","EU_REACH:
+Experimental study (OECD TG 404, GLP)
+
+JP_CHRIP:
+[Rationale for the Classification]
+It was classified as ""Not classified"" from (1).
+
+[Evidence Data]
+(1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 72-hour observation), no skin irritation was seen (erythema/eschar score: 0/0/0, edema score: 0/0/0) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2009), REACH registration dossier (Accessed Sep. 2020), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2009)).",Provided,"EU_REACH, JP_CHRIP",2,CS(=O)(=O)c1ccc(C(=O)C2C(=O)CCCC2=O)c(Cl)c1COCC1CCCO1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.715.929J,J-GLOBAL,CS(=O)(=O)c1ccc(C(=O)C2C(=O)CCCC2=O)c(Cl)c1COCC1CCCO1,Train,254,1,testing
+"NZ_CCID:
+Crotonic acid nitrile",,4786-20-3,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/03927C75-FA93-48B1-883A-03307CA8429E,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [CHEMWATCH]
+Eye Irritation
+R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C/C=C/C#N,https://pubchem.ncbi.nlm.nih.gov/compound/637921,PubChem,C/C=C/C#N,Train,255,1,testing
+"US_HSDB:
+Jasmone",,488-10-8,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8273,,,US_HSDB,1,CC/C=C\CC1=C(CCC1=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/1549018,PubChem,CC/C=C\CC1=C(C)CCC1=O,Train,256,1,testing
+"EU_REACH:
+perhydroimidazo[4,5-d]imidazole-2,5-dione",,496-46-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24399/7/4/2/?documentUUID=b4392fab-3bce-4bad-87bf-c609a6242b28,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C12C(NC(=O)N1)NC(=O)N2,https://pubchem.ncbi.nlm.nih.gov/compound/62347,PubChem,O=C1NC2NC(=O)NC2N1,Train,257,1,testing
+"EU_CLP:
+formaldehyde …%",,50-00-0,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C=O,https://pubchem.ncbi.nlm.nih.gov/compound/712,PubChem,C=O,Test,258,1,testing
+"EU_REACH:
+ethyl 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxylate",,503614-91-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20591/7/4/2/?documentUUID=239340f9-263c-42ea-a727-5764dfacd595,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1=NN(C2=C1CCN(C2=O)C3=CC=C(C=C3)N4CCCCC4=O)C5=CC=C(C=C5)OC,https://pubchem.ncbi.nlm.nih.gov/compound/22240488,PubChem,CCOC(=O)c1nn(-c2ccc(OC)cc2)c2c1CCN(c1ccc(N3CCCCC3=O)cc1)C2=O,Train,259,2,testing
+"EU_REACH:
+ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxylate",,536759-91-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7872/7/4/2/?documentUUID=d569acfe-1f49-49fa-b577-6357b6cd530c,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)C1=NN(C2=C1CCN(C2=O)C3=CC=C(C=C3)[N+](=O)[O-])C4=CC=C(C=C4)OC,https://pubchem.ncbi.nlm.nih.gov/compound/11711790,PubChem,CCOC(=O)c1nn(-c2ccc(OC)cc2)c2c1CCN(c1ccc([N+](=O)[O-])cc1)C2=O,Train,259,2,testing
+"US_HSDB:
+Mercaptopurine",,50-44-2,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/3235,,,US_HSDB,1,C1=NC2=C(N1)C(=S)N=CN2,https://pubchem.ncbi.nlm.nih.gov/compound/667490,PubChem,S=c1nc[nH]c2nc[nH]c12,Train,260,4,testing
+"EU_REACH:
+xanthine",,69-89-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33594/7/4/2/?documentUUID=99d29b75-b5f2-4195-981f-c50051874dd3,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=NC2=C(N1)C(=O)NC(=O)N2,https://pubchem.ncbi.nlm.nih.gov/compound/1188,PubChem,O=c1[nH]c(=O)c2[nH]cnc2[nH]1,Train,260,4,testing
+"NZ_CCID:
+1H-Purine-2,6,8(3H)-trione, 7,9-dihydro-",,69-93-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/36B089CD-DB36-4D4F-9B33-78B20557CE4D,"NZ_CCID:
+Skin Irritation
+R-PHRASE: R 38
+Eye Irritation
+R-PHRASE: R 36",,NZ_CCID,1,C12=C(NC(=O)N1)NC(=O)NC2=O,https://pubchem.ncbi.nlm.nih.gov/compound/1175,PubChem,O=c1[nH]c(=O)c2[nH]c(=O)[nH]c2[nH]1,Train,260,4,testing
+"NZ_CCID:
+6H-Purin-6-one, 2-amino-1,7-dihydro-",,73-40-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/126471A4-F9BA-468D-A5E6-79A6F57C0394,,,NZ_CCID,1,C1=NC2=C(N1)C(=O)NC(=N2)N,https://pubchem.ncbi.nlm.nih.gov/compound/135398634,PubChem,Nc1nc2nc[nH]c2c(=O)[nH]1,Train,260,4,testing
+"JP_CHRIP:
+Cyanogen chloride
+
+KR_NCIS:
+Cyanogen chloride","JP_CHRIP:
+Chlorine cyanide
+Chlorocyan
+Chlorocyanide
+Chlorocyanogen
+Cyanogen chloride ((CN)Cl)",506-77-4,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2109e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP:
+Although there is no concrete information, there is a description that the vapor of this substance may damage the skin (HSDB (Access on September 2014)). The subsidiary hazard for the Transport of Dangerous Goods of this substance is 8. From the above, it was classified in Category 1.",,"JP_CHRIP, KR_NCIS",2,ClC#N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.609C,J-GLOBAL,N#CCl,Train,261,2,testing
+"JP_CHRIP:
+Trichloroacetonitrile",,545-06-2,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-2037e.html,"JP_CHRIP:
+It was classified in Category 2 because it is described in RTECS (2003) (the original article: Marhold, J. (1986)) that severe irritation was observed after 24-hour application in a skin irritation test with rabbits.",,JP_CHRIP,1,ClC(Cl)(Cl)C#N,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.649B,J-GLOBAL,N#CC(Cl)(Cl)Cl,Train,261,2,testing
+"EU_REACH:
+methyl (2S,4S,5R,6R)-5-acetamido-2,4-dihydroxy-6-[(2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylate hydrate",,50998-13-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1295/7/4/2/?documentUUID=b96cae5d-ba6d-4a15-833a-96105a686087,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)N[C@@H]1[C@H](C[C@](O[C@H]1[C@@H]([C@@H](CO)O)O)(C(=O)OC)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/7173831,PubChem,COC(=O)[C@]1(O)C[C@H](O)[C@@H](NC(C)=O)[C@H]([C@H](O)[C@H](O)CO)O1,Train,262,1,testing
+"AU_HCIS:
+Oxazolidine, 4,4-dimethyl-
+
+US_HSDB:
+4,4-Dimethyl oxazolidine",,51200-87-4,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6483
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8295",,,"AU_HCIS, US_HSDB",2,CC1(COCN1)C,https://pubchem.ncbi.nlm.nih.gov/compound/62010,PubChem,CC1(C)COCN1,Train,263,1,testing
+"EU_REACH:
+2,4,4-trimethylpentan-2-yl 2,2,3,5-tetramethylhexaneperoxoate; 2,4,4-trimethylpentan-2-yl 2,2-diethylhexaneperoxoate; 2,4,4-trimethylpentan-2-yl 2,2-dimethyloctaneperoxoate; 2,4,4-trimethylpentan-2-yl 2,4-dimethyl-2-(propan-2-yl)pentaneperoxoate; 2,4,4-trimethylpentan-2-yl 2-ethyl-2,5-dimethylhexaneperoxoate",,51240-95-0,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10637/7/4/2/?documentUUID=c201886c-4065-4c27-a251-ebb4d0610fba,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)CCCCC1(OO1)C(=O)OC(C)(C)CC(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/6452377,PubChem,CC(C)(C)CCCCC1(C(=O)OC(C)(C)CC(C)(C)C)OO1,Train,264,1,testing
+"NZ_CCID:
+1-Propene, 1-chloro-2-methyl-",,513-37-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FB5FAA97-884E-425D-B27E-09018DDF2E3F,"NZ_CCID:
+Skin Irritation
+R-PHRASE: R 36/ 37/ 38. [Company data]
+Eye Irritation
+R-PHRASE: R 36/ 37/ 38. [Company data]",,NZ_CCID,1,CC(=CCl)C,https://pubchem.ncbi.nlm.nih.gov/compound/10555,PubChem,CC(C)=CCl,Train,265,2,testing
+"AU_HCIS:
+Ethene, trichloro
+
+JP_CHRIP:
+Trichloroethylene
+
+KR_NCIS:
+Trichloroethylene
+
+NZ_CCID:
+Ethene, trichloro-
+
+US_HSDB:
+Trichloroethylene","AU_HCIS:
+Trichloroethylene
+Trichloroethene
+
+JP_CHRIP:
+1,1,2-Trichloroethylene
+Acetylene trichloride
+ethene, trichloro-
+Ethylene trichloride
+TCE
+Trichlene
+Trichloroethene
+Trichloroethylene
+
+KR_NCIS:
+Trichloroethene; Ethylene trichloride; 1,1,2-Trichloroethene; Acetylene trichloride; Ethinyl trichloride
+
+NZ_CCID:
+1,1,2-Trichloroethylene, Ethinyl trichloride, Ethylene trichloride, R1120, Trichloroethylene",79-01-6,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=4815
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2019e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/207750AE-71F3-429D-8C69-A9296029C6E6
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/133","JP_CHRIP:
+From a report that in the case of humans, dermatitis and erythema were caused by exposure to this substance in an occupational environment (ASTDR (1997)) and a report that marked skin irritation was observed in skin irritation tests with rabbits and guinea pigs (EU-RAR (2004)), it was classified in Category 2. Besides, in EU CLP classification, this substance was classified as Skin Irrit. 2 (ECHA CL Inventory (Access on May 2017)).
+
+NZ_CCID:
+Skin Irritation
+R-PHRASE: R 38 Irritating to the skin. [NICNAS 2000]
+Eye Irritation
+SPECIES:
+RESULT: No animal tests complying with standard protocols for detecting eye effects of trichoroethaylenbe have been reported. Two studies reported corneal abrasions and necrosis of the cornea following instillation of trichlorethylene into rabbit eyes.
+REFERENCE SOURCE: [NICNAS 2000].
+EXPERT JUDGEMENT: Irritating to the skin - assume irritates eye also, assumption supported by limited data.",,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",5,ClC=C(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.408C,J-GLOBAL,ClC=C(Cl)Cl,Train,265,2,testing
+"EU_REACH:
+2-(2-aminopropan-2-yl)-N-[(4-fluorophenyl)methyl]-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide",,518048-03-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/28361/7/4/2/?documentUUID=0bf809e0-592d-41d3-bf4c-529369b8a6ab,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C1=NC(=C(C(=O)N1C)O)C(=O)NCC2=CC=C(C=C2)F)N,https://pubchem.ncbi.nlm.nih.gov/compound/54721880,PubChem,Cn1c(C(C)(C)N)nc(C(=O)NCc2ccc(F)cc2)c(O)c1=O,Train,266,1,testing
+"NZ_CCID:
+Penicillium citrinium",,518-75-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E5DFEA2A-0E8A-4C56-86BA-B28D92DC1267,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [CHEMWATCH]",,NZ_CCID,1,C[C@@H]1[C@H](OC=C2C1=C(C(=C(C2=O)C(=O)O)O)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/54680783,PubChem,CC1=C2C(=CO[C@H](C)[C@H]2C)C(=O)C(C(=O)O)=C1O,Train,267,1,testing
+"US_HSDB:
+Isopsoralen",,523-50-2,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/3554,,,US_HSDB,1,C1=CC2=C(C=CO2)C3=C1C=CC(=O)O3,https://pubchem.ncbi.nlm.nih.gov/compound/10658,PubChem,O=c1ccc2ccc3occc3c2o1,Train,268,3,testing
+"US_HSDB:
+Psoralen",,66-97-7,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/3528,,,US_HSDB,1,C1=CC(=O)OC2=CC3=C(C=CO3)C=C21,https://pubchem.ncbi.nlm.nih.gov/compound/6199,PubChem,O=c1ccc2cc3ccoc3cc2o1,Train,268,3,testing
+"NZ_CCID:
+Coumarin","NZ_CCID:
+2H-1-Benzopyran-2-one, o-Hydroxycinnamic acid lactone",91-64-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/48FBA96C-82E8-4608-9C1D-A7BCBF6B3546,"NZ_CCID:
+Skin Irritation
+SPECIES:
+RESULT: Irritating
+REFERENCE SOURCE: International Chemical Safety Card [INCHEM]",,NZ_CCID,1,C1=CC=C2C(=C1)C=CC(=O)O2,https://pubchem.ncbi.nlm.nih.gov/compound/323,PubChem,O=c1ccc2ccccc2o1,Train,268,3,testing
+"ChemSkin:
+1-Methyl-3-phenyl-1-piperazine #, ###
+
+EU_CLP:
+1-methyl-3-phenyl-1-piperazine",,5271-27-2,Cat 2,"ChemSkin: https://doi.org/10.3390/toxics9110314
+EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,Provided,"ChemSkin, EU_CLP",2,CN1CCNC(C1)C2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/2760009,PubChem,CN1CCNC(c2ccccc2)C1,Test,269,1,testing
+"NZ_CCID:
+2-Nitroimidazole",,527-73-1,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/952FCB7A-13FC-4237-9883-2098AC87EB03,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1=CN=C(N1)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/10701,PubChem,O=[N+]([O-])c1ncc[nH]1,Train,270,2,testing
+"AU_HCIS:
+1H-Imidazole, 2-methyl-
+
+NZ_CCID:
+2-Methylimidazole","AU_HCIS:
+2-methylimidazole",693-98-1,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5544
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/37D0723A-BB63-472E-8837-D7D171CC92DF","NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,"AU_HCIS, NZ_CCID",2,CC1=NC=CN1,https://pubchem.ncbi.nlm.nih.gov/compound/12749,PubChem,Cc1ncc[nH]1,Train,270,2,testing
+"EU_REACH:
+(1S,5R)-6,8-dioxabicyclo[3.2.1]octan-4-one",,53716-82-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16252/7/4/2/?documentUUID=c20de59c-a0f0-4651-9249-58e43c22b425,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC(=O)[C@@H]2OC[C@H]1O2,https://pubchem.ncbi.nlm.nih.gov/compound/10975499,PubChem,O=C1CC[C@H]2CO[C@@H]1O2,Train,271,1,testing
+"NZ_CCID:
+2,2,6-Trimethyl-1,3-dioxine-4-one","NZ_CCID:
+2,2,6-trimethyl-1,3-dioxin-4-one",5394-63-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7B385329-D88C-413E-B00A-8662071CEA4F,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1=CC(=O)OC(O1)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/79368,PubChem,CC1=CC(=O)OC(C)(C)O1,Train,272,1,testing
+"JP_CHRIP:
+1,2-Dimethylhydrazine","JP_CHRIP:
+SDMH",540-73-8,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-0006e.html,"JP_CHRIP:
+[Rationale for the Classification]
+Based on (1), it was classified in Category 1.
+
+[Evidence Data]
+(1) This substance is strongly alkaline, so it is considered to be corrosive and irritating to the skin, eyes, and mucous membranes (PATTY (6th, 2012)).
+
+[Reference Data, etc.]
+(2) There is a description that contact with this substance may cause irritation to the skin, eyes, and mucous membranes (HSDB (Access on June 2019)).
+(3) Dermal discoloration and irritation were observed in dogs, rabbits and guinea pigs on dermal exposure to this substance (ATSDR (1997)).",,JP_CHRIP,1,CNNC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.643I,J-GLOBAL,CNNC,Train,273,2,testing
+"JP_CHRIP:
+methylhydrazine
+
+KR_NCIS:
+Methylhydrazine","JP_CHRIP:
+1-Methylhydrazine
+Hydrazomethane
+MMH
+Monomethylhydrazine
+
+KR_NCIS:
+Methyl hydrazine",60-34-4,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0238e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP:
+Based on the description that erythema and edema were observed in dog skin application test, though the exposure time was unknown (ACGIH (7th, 2004) and PATTY (4th, 1994)) and that there is possibility of severe damage on human skin (PATTY (4th, 1994)), it was classified as Category 2.",,"JP_CHRIP, KR_NCIS",2,CNN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.338H,J-GLOBAL,CNN,Train,273,2,testing
+"EU_REACH:
+dodecamethylcyclohexasiloxane",,540-97-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15811/7/4/2/?documentUUID=828f592a-f551-4b82-aa96-98d10c80aae9,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si]1(O[Si](O[Si](O[Si](O[Si](O[Si](O1)(C)C)(C)C)(C)C)(C)C)(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/10911,PubChem,C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1,Train,274,2,testing
+"EU_REACH:
+hexamethyl-1,3,5,2,4,6-trioxatrisilinane",,541-05-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14554/7/4/2/?documentUUID=74ca7a5a-d916-4238-beb9-f1ae243aa445,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[Si]1(O[Si](O[Si](O1)(C)C)(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/10914,PubChem,C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O1,Train,274,2,testing
+"JP_CHRIP:
+3-(1-Methyl-2-pyrrolidinyl)pyridine; Nicotine","JP_CHRIP:
+(S)-3-(1-Methylpyrrolidin-2-yl)pyridine
+1-Methyl-2-(3-pyridyl)pyrrolidine
+3-(1-Methyl-2-pyrrolidinyl)pyridine
+beta-Pyridyl-alpha-N-methylpyrrolidine",54-11-5,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2101e.html,"JP_CHRIP:
+[Rationale for the Classification]
+It was classified in Category 2 from (1) - (3). Because new data (1) - (3) were obtained, the classification result was changed.
+
+[Evidence Data]
+(1) This substance was locally irritating to the skin (Patty (6th, 2012)).
+(2) This substance was irritating to the skin (GESTIS (Access on June 2020)).
+(3) In an acute dermal administration toxicity test with rabbits according to OECD TG 402 on this substance, slight to severe erythema was observed, and it was concluded that it was not corrosive but irritating (REACH registration dossier (Access on September 2020)).
+
+[Reference Data, etc.]
+(4) It is reported that erythema was found due to patches containing this substance (smoking cessation drug) in some volunteers (MAK (DFG) (2014)).",,JP_CHRIP,1,CN1CCC[C@H]1c1cccnc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J9.266E,J-GLOBAL,CN1CCC[C@H]1c1cccnc1,Train,275,1,testing
+"NZ_CCID:
+Dimetridazole",,551-92-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CC79098A-C3A3-47EE-8CE2-FE236B3E1390,"NZ_CCID:
+Skin Irritation
+R-PHRASE: R 38 Irritating to skin. MSDS. [SIGMA-ALDRICH]
+Eye Irritation
+R-PHRASE: R 36 Irritating to eyes. MSDS. [SIGMA-ALDRICH]",,NZ_CCID,1,CC1=NC=C(N1C)[N+](=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/3090,PubChem,Cc1ncc([N+](=O)[O-])n1C,Train,276,1,testing
+"JP_CHRIP:
+O-6-Chloro-3-phenyl-4-pyridazinyl S-n-octyl thiocarbonate; Pyridate
+
+NZ_CCID:
+Pyridate",,55512-33-9,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0516e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/901B0109-6AED-4377-B40F-08C80E7AF397","JP_CHRIP:
+Based on the description in the report on rabbit skin irritation tests (IUCLD (2000)): ""Irritating"" (though the severity of the effects is unknown).
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [NCLASS]
+Eye Irritation
+Not irritating to eyes.
+[EC PESTICIDES REVIEW]",,"JP_CHRIP, NZ_CCID",2,CCCCCCCCSC(=O)Oc1cc(Cl)nnc1c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J14.345F,J-GLOBAL,CCCCCCCCSC(=O)Oc1cc(Cl)nnc1-c1ccccc1,Train,277,1,testing
+"NZ_CCID:
+Methyl thiocyanate",,556-64-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9C65C463-6C36-4310-91E3-A200B3C93FBE,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CSC#N,https://pubchem.ncbi.nlm.nih.gov/compound/11168,PubChem,CSC#N,Train,278,1,testing
+"EU_REACH:
+2-ethyl-4,4-dimethylcyclohexan-1-one",,55739-89-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30121/7/4/2/?documentUUID=199b9226-5e09-4248-b23b-7fd15c84257c,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1CC(CCC1=O)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/11126487,PubChem,CCC1CC(C)(C)CCC1=O,Train,279,2,testing
+"EU_REACH:
+3-ethyl-5,5-dimethyloxolan-2-one",,66094-79-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33920/7/4/2/?documentUUID=e85aff9b-4c5d-4214-9d6b-59f3af539f2b,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC1CC(OC1=O)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/12393270,PubChem,CCC1CC(C)(C)OC1=O,Train,279,2,testing
+"NZ_CCID:
+Cantharidin",,56-25-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5DC7778F-4B68-4A0B-80BA-AE8D2A1D8534,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 35 [CHEMWATCH]
+Eye Irritation
+R PHRASE: R 41 [CHEMWATCH]",,NZ_CCID,1,C[C@@]12[C@H]3CC[C@@H]([C@@]1(C(=O)OC2=O)C)O3,https://pubchem.ncbi.nlm.nih.gov/compound/5944,PubChem,C[C@@]12C(=O)OC(=O)[C@]1(C)[C@H]1CC[C@@H]2O1,Train,280,1,testing
+"US_HSDB:
+4-Terpineol",,562-74-3,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8264,,,US_HSDB,1,CC1=CCC(CC1)(C(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/11230,PubChem,CC1=CCC(O)(C(C)C)CC1,Train,281,1,testing
+"EU_REACH:
+3-((3,4-dicyanophenyl)sulfonyl)-N-(2-hydroxypropyl)propane-1-sulfonamide",,569316-81-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24236/7/4/2/?documentUUID=4422612f-f35c-4551-befb-57b09cb8304b,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(CNS(=O)(=O)CCCS(=O)(=O)C1=CC(=C(C=C1)C#N)C#N)O,https://pubchem.ncbi.nlm.nih.gov/compound/57901542,PubChem,CC(O)CNS(=O)(=O)CCCS(=O)(=O)c1ccc(C#N)c(C#N)c1,Train,282,1,testing
+"EU_CLP:
+N,N-dimethylhydrazine",,57-14-7,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CN(C)N,https://pubchem.ncbi.nlm.nih.gov/compound/5976,PubChem,CN(C)N,Test,283,1,testing
+"JP_CHRIP:
+1,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methano-1H-indene; Chlordane","JP_CHRIP:
+1,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methano-1H-indene
+1,2,4,5,6,7,8,8-Octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methanoindene
+4,7-Methano-1H-indene, 1,2,4,5,6,7,8,8-octachloro-2,3,3a,4,7,7a-hexahydro-
+Chlordane
+mixture of 1,2,4,5,6,7,8,8-octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methano-1H-indene, 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-4,7-methano-1H-indene or their relative compounds",57-74-9,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2033e.html,"JP_CHRIP:
+[Rationale for the Classification]
+It was classified in Category 2 from (1), (2).
+
+[Evidence Data]
+(1) It was extremely irritating to rabbits' eyes but produced only mild irritant to their skin (IPCS PIM 574 (2000)).
+(2) This substance of technical grade was irritating to the skin and eye (HSDB (Access on May 2020)).
+
+[Reference Data, etc.]
+(3) Early use of this substance resulted in irritation of the eyes, mucous membranes, and skin of industrial and agricultural workers, but this did not appear to be a problem with the product manufactured since 1951 (HSDB (Access on May 2020)).",,JP_CHRIP,1,ClC1CC2C(C1Cl)C1(Cl)C(=C(Cl)C2(Cl)C1(Cl)Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.407E,J-GLOBAL,ClC1=C(Cl)C2(Cl)C3C(Cl)C(Cl)CC3C1(Cl)C2(Cl)Cl,Train,284,1,testing
+"NZ_CCID:
+Clozapine",,5786-21-0,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/33E305EF-FF59-4A8B-A20A-F7EE1E114ACE,"NZ_CCID:
+Skin Irritation
+REMARK: Confidential information supplied by registrant.
+Eye Irritation
+REMARK: Confidential information supplied by registrant.",,NZ_CCID,1,CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42,https://pubchem.ncbi.nlm.nih.gov/compound/135398737,PubChem,CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1,Train,285,1,testing
+"JP_CHRIP:
+caffeine","JP_CHRIP:
+1,3,7-Trimethylxanthine
+1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-
+3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
+Caffeine
+Methyltheobromine
+Methyltheophylline",58-08-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0136e.html,"JP_CHRIP:
+Since in a test using rabbits (OECD TG 404), the substance in a 50% aqueous dilution was not irritating to the skin of rabbits (irritation index was 0) (SIDS (accessed in September 2008)), it was classified into ""Not classified"".",Provided,JP_CHRIP,1,Cn1cnc2n(C)c(=O)n(C)c(=O)c12,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.330B,J-GLOBAL,Cn1c(=O)c2c(ncn2C)n(C)c1=O,Train,286,2,testing
+"JP_CHRIP:
+Theophylline","JP_CHRIP:
+1,3-Dimethyl-1H-purine-2,6(3H,7H)-dione
+1,3-Dimethylxanthine
+3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione
+Theophylline",58-55-9,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0023e.html,"JP_CHRIP:
+In a test by a 4-hour semi-occlusive application of 0.5 g of a 50% solution of this substance to the skin of three rabbits (OECD TG404), only slight erythema was observed in two animals 4 hours after the application, and no irritation symptoms were seen at observation after 24, 48, and 72 hours. And the average irritation index (PDII) was 0, and it was judged as not irritating (SIDS (2003)). Therefore, it was classified as ""Not classified.""",Provided,JP_CHRIP,1,Cn1c2nc[nH]c2c(=O)n(C)c1=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.333G,J-GLOBAL,Cn1c(=O)c2[nH]cnc2n(C)c1=O,Train,286,2,testing
+"ChemSkin:
+4-Amino-4H-1,2,4-triazole (4-amino-1,2,4-triazole)",,584-13-4,NC,ChemSkin: https://doi.org/10.3390/toxics9110314,"ChemSkin:
+Experimental study (OECD TG 404)",Provided,ChemSkin,1,C1=NN=CN1N,https://pubchem.ncbi.nlm.nih.gov/compound/11432,PubChem,Nn1cnnc1,Test,287,1,testing
+"NZ_CCID:
+Hydrochlorothiazide",,58-93-5,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D2EF926C-1052-4B19-96F7-0718A3AD317D,"NZ_CCID:
+Skin Irritation
+REMARK: Confidential information supplied by registrant
+Eye Irritation
+REMARK: Confidential information supplied by registrant",,NZ_CCID,1,C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/3639,PubChem,NS(=O)(=O)c1cc2c(cc1Cl)NCNS2(=O)=O,Train,288,1,testing
+"EU_REACH:
+2-methyl-4-propyl-1,3-oxathiane",,59323-76-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12066/7/4/2/?documentUUID=ac517391-2627-4486-b003-d7f774fdb0f7,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCC[C@@H]1CCO[C@@H](S1)C,https://pubchem.ncbi.nlm.nih.gov/compound/6931728,PubChem,CCC[C@@H]1CCO[C@H](C)S1,Train,289,1,testing
+"NZ_CCID:
+2,2,2-Trichloroethyl dichlorophosphite",,60010-51-7,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C515FC67-A1FE-418A-9D10-1225D7BA6CA0,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(C(Cl)(Cl)Cl)OP(Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/108874,PubChem,ClP(Cl)OCC(Cl)(Cl)Cl,Train,290,1,testing
+"EU_REACH:
+(4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexan-1-one",,60046-50-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30135/7/4/2/?documentUUID=c9ef930f-966f-4ba3-b938-0e8036baed5d,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H]1C[C@H](CC(C1=O)(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/10313234,PubChem,C[C@@H]1C[C@@H](O)CC(C)(C)C1=O,Train,291,1,testing
+"EU_REACH:
+(3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propanocyclopenta[8]annulen-8-yl[(methylsulfonyl)oxy]acetate",,60924-38-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1391/7/4/2/?documentUUID=1d4d37c5-9f0b-46dc-8c6f-417cadbbb176,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H]1CC[C@]23CCC(=O)[C@@H]2[C@]1([C@H](C[C@]([C@@H]([C@H]3C)O)(C)C=C)OC(=O)COS(=O)(=O)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/71307485,PubChem,C=C[C@@]1(C)C[C@H](OC(=O)COS(C)(=O)=O)[C@@]2(C)[C@H](C)CC[C@@]3(CCC(=O)[C@@H]32)[C@H](C)[C@H]1O,Train,292,1,testing
+"EU_REACH:
+2-acetyl-1H,2H,3H,4H,6H,7H,11bH-pyrazino[2,1-a]isoquinolin-4-one",,61196-40-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30142/7/4/2/?documentUUID=7d5130cc-06da-4f0d-88b8-c761ee23da63,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=O)N1CC2C3=CC=CC=C3CCN2C(=O)C1,https://pubchem.ncbi.nlm.nih.gov/compound/13063820,PubChem,CC(=O)N1CC(=O)N2CCc3ccccc3C2C1,Train,293,1,testing
+"NZ_CCID:
+Dimethyl sulphite",,616-42-2,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2C1F0707-C854-4832-B77A-CE90F31E6A71,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,COS(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/69223,PubChem,COS(=O)OC,Train,294,1,testing
+"US_HSDB:
+PAROXETINE",,61869-08-7,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/7175,,,US_HSDB,1,C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4,https://pubchem.ncbi.nlm.nih.gov/compound/43815,PubChem,Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1,Train,295,1,testing
+"EU_REACH:
+ß-D-Ribofuranose, 5-deoxy-, triacetate (6CI,9CI)",,62211-93-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5849/7/4/2/?documentUUID=943258ba-8892-445c-b8d8-840478146b84,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H]1[C@H]([C@H]([C@@H](O1)OC(=O)C)OC(=O)C)OC(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/11821332,PubChem,CC(=O)O[C@@H]1O[C@H](C)[C@@H](OC(C)=O)[C@H]1OC(C)=O,Train,296,1,testing
+"EU_CLP:
+8,8-dimethyl-7-isopropyl-6,10-dioxaspiro[4.5]decane",,62406-73-9,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C)C1C(COC2(O1)CCCC2)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/236674,PubChem,CC(C)C1OC2(CCCC2)OCC1(C)C,Test,297,1,testing
+"JP_CHRIP:
+Dimethyl disulfide","JP_CHRIP:
+Dimethyl disulfide
+Dimethyldisulfide
+Disulfide, dimethyl-
+Methyl disulfide",624-92-0,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0791e.html,"JP_CHRIP:
+It was classified as Category 2 based on the description that moderate to severe erythema and edema were observed on rabbits (ECETOC TR66 (1995), PATTY(5th, 2001) vol.7).",,JP_CHRIP,1,CSSC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.683G,J-GLOBAL,CSSC,Train,298,2,testing
+"EU_REACH:
+(methylsulfanyl)methane
+
+JP_CHRIP:
+Dimethyl sulfide","JP_CHRIP:
+Methylsulphide
+Thiobismethane",75-18-3,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13649/7/4/2/?documentUUID=b055a0b6-dd88-46ee-afc0-90af881659c0
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2134e.html","EU_REACH:
+Experimental study (OECD TG 404, GLP)
+
+JP_CHRIP:
+There are reports that slight irritation was observed after occlusive application of this substance (undiluted) to rabbits for 24 hours (SIDS (2007)), and that when this substance was applied to the skin of rabbits (application time unknown), a primary irritation score of 0.4 (0-8) was obtained, indicating slight irritation (ACGIH (7th, 2004)). In addition, it is described that it is slightly irritating to rabbit skin (PATTY (6th, 2012)). From the above results, it was classified as ""Not classified"" (Category 3 in UN GHS classification). New information was added (SIDS (2007)), and the classification was revised according to the revised GHS classification guidance for the Japanese government.",Provided,"EU_REACH, JP_CHRIP",2,CSC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.443E,J-GLOBAL,CSC,Train,298,2,testing
+"EU_CLP:
+2-cyclopentylidene cyclopentanol; 1,1'-bi(cyclopentyliden)-2-ol",,6261-30-9,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1CCC(=C2CCCC2O)C1,https://pubchem.ncbi.nlm.nih.gov/compound/579236,PubChem,OC1CCCC1=C1CCCC1,Test,299,1,testing
+"JP_CHRIP:
+N,N-Dimethylnitrosamine","JP_CHRIP:
+Dimethylnitrosamine
+DMN
+Methanamine, N-methyl-N-nitroso-
+N,N-Dimethylnitrosoamine
+N-Methyl-N-nitrosomethylamine
+N-Nitrosodimethylamine",62-75-9,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2050e.html,"JP_CHRIP:
+Based on a description that this substance was irritating to the skin (Environmental Risk Assessment for Chemical Substances Vol.10 (Ministry of the Environment, 2012), HSDB (Access on July 2014)), it was classified in Category 2. The category was changed by deleting the information sources in List 3 and adding new ones.",,JP_CHRIP,1,CN(C)N=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.928C,J-GLOBAL,CN(C)N=O,Train,300,1,testing
+"EU_REACH:
+1,1,2-trimethyl-3-(4-sulfobutyl)-1H-benzo[e]indol-3-ium",,63149-24-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/29957/7/4/2/?documentUUID=1c810e17-3736-4cb1-a639-e58c7358ec43,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=[N+](C2=C(C1(C)C)C3=CC=CC=C3C=C2)CCCCS(=O)(=O)[O-],https://pubchem.ncbi.nlm.nih.gov/compound/113092,PubChem,CC1=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c2C1(C)C,Train,301,1,testing
+"EU_REACH:
+4-methyl-2-(2-methylpropyl)oxan-4-ol",,63500-71-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14480/7/4/2/?documentUUID=1ecdbdcf-6118-41dd-88a7-308e75649af9,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)CC1CC(CCO1)(C)O,https://pubchem.ncbi.nlm.nih.gov/compound/3017432,PubChem,CC(C)CC1CC(C)(O)CCO1,Train,302,1,testing
+"NZ_CCID:
+Bilirubin","NZ_CCID:
+21H-Biline-8,12-dipropanoic acid, 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-",635-65-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D8429E7E-324F-4666-8FC0-6474DDAB1722,"NZ_CCID:
+Skin Irritation
+R-PHRASE: R 36/37/38 Irritating to eyes, respiratory system and skin.
+
+Eye Irritation
+R-PHRASE: R 36/37/38 Irritating to eyes, respiratory system and skin.",,NZ_CCID,1,CC1=C(NC(=C1CCC(=O)O)CC2=C(C(=C(N2)/C=C\3/C(=C(C(=O)N3)C)C=C)C)CCC(=O)O)/C=C\4/C(=C(C(=O)N4)C=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/5280352,PubChem,C=CC1=C(C)/C(=C/c2[nH]c(Cc3[nH]c(/C=C4\NC(=O)C(C)=C4C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C)NC1=O,Train,303,1,testing
+"EU_REACH:
+Resin acids and Rosin acids, hydrogenated, esters with pentaerythritol",,64365-17-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11459/7/4/2/?documentUUID=63825caf-cad2-40a7-998b-1a5d35124c70,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1=CC2=CC[C@@H]3[C@@]([C@H]2CC1)(CCC[C@@]3(C)C(=O)OCC(CO)(CO)CO)C,https://pubchem.ncbi.nlm.nih.gov/compound/72941941,PubChem,CC(C)C1=CC2=CC[C@@H]3[C@](C)(CCC[C@@]3(C)C(=O)OCC(CO)(CO)CO)[C@H]2CC1,Train,304,3,testing
+"EU_REACH:
+Resin acids and rosin acids, Me esters",,68186-14-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10758/7/4/2/?documentUUID=923d372e-ac82-4be3-a5fa-64c27c79b78e,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1=CC2=CCC3[C@@]([C@@H]2CC1)(CCC[C@]3(C)C(=O)OC)C,https://pubchem.ncbi.nlm.nih.gov/compound/18634581,PubChem,COC(=O)[C@@]1(C)CCC[C@@]2(C)C1CC=C1C=C(C(C)C)CC[C@H]12,Train,304,3,testing
+"EU_REACH:
+Resin acids and rosin acids, ester with glycerol",,8050-31-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15312/7/4/2/?documentUUID=61a6c1d6-7bea-44e2-8d21-71036db88b2e,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)C1=CC2=CC[C@@H]3[C@@]([C@H]2CC1)(CCC[C@@]3(C)C(=O)OCC(CO)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/11852355,PubChem,CC(C)C1=CC2=CC[C@@H]3[C@](C)(CCC[C@@]3(C)C(=O)OCC(O)CO)[C@H]2CC1,Train,304,3,testing
+"AU_HCIS:
+2,4-Imidazolidinedione, 1,3-bis(hydroxymethyl)-5,5-dimethyl-",,6440-58-0,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5041,,,AU_HCIS,1,CC1(C(=O)N(C(=O)N1CO)CO)C,https://pubchem.ncbi.nlm.nih.gov/compound/22947,PubChem,CC1(C)C(=O)N(CO)C(=O)N1CO,Train,305,1,testing
+"EU_REACH:
+2,2,5-trimethyl-5-pentylcyclopentan-1-one",,65443-14-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17440/7/4/2/?documentUUID=a84c225c-f484-430c-b906-6b778ec057af,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCCC1(CCC(C1=O)(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/103402,PubChem,CCCCCC1(C)CCC(C)(C)C1=O,Train,306,1,testing
+"KR_NCIS:
+Furathiocarb","KR_NCIS:
+2,3-Dihydro-2,2-dimethyl-7-benzofuryl 2,4-dimethyl-6-oxa-5-oxo-3-thia-2,4-diazadecanoate",65907-30-4,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CCCCOC(=O)N(C)SN(C)C(=O)OC1=CC=CC2=C1OC(C2)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/47759,PubChem,CCCCOC(=O)N(C)SN(C)C(=O)Oc1cccc2c1OC(C)(C)C2,Train,307,1,testing
+"EU_REACH:
+8-bromo-7-(but-2-yn-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione",,666816-98-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17504/7/4/2/?documentUUID=8b2e1d5d-9623-47ac-8507-2acd111690f7,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC#CCN1C2=C(N=C1Br)N(C(=O)NC2=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/21088927,PubChem,CC#CCn1c(Br)nc2c1c(=O)[nH]c(=O)n2C,Test,308,1,testing
+"JP_CHRIP:
+cicloheximide","JP_CHRIP:
+2,6-Piperidinedione
+2,6-Piperidinedione, 4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-, [1S-[1alpha(S*),3alpha,5beta]]-
+3-[2-(3,5-dimethyl-2-oxo-1-cyclohexyl)-2-hydroxyethyl]glutarimide
+4-(2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)
+beta-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide",66-81-9,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-1221e.html,"JP_CHRIP:
+Since there is a stimulate of ""Moderate (moderately)"" in Standard Draize Test in a rabbit (RTECS (2004)), and there was description that the human skin is stimulated (ICSC (J), (1997), HSDB (2002), SITTIG (4th, 2002), HSFS (1999)), it was set as category 2.",,JP_CHRIP,1,C[C@H]1C[C@H](C)C(=O)[C@@H](C1)[C@H](O)CC1CC(=O)NC(=O)C1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J107.994H,J-GLOBAL,C[C@@H]1C[C@@H]([C@H](O)CC2CC(=O)NC(=O)C2)C(=O)[C@@H](C)C1,Train,309,1,testing
+"EU_REACH:
+4-methyl-2,6-bis[(4-methylphenyl)amino]-5-{2-[2-(trifluoromethyl)phenyl]diazen-1-yl}pyridine-3-carbonitrile",,669005-94-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6226/7/4/2/?documentUUID=ee862930-5008-46f2-a1c9-edf15ae4d9ec,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)NC2=C(C(=C(C(=N2)NC3=CC=C(C=C3)C)C#N)C)N=NC4=CC=CC=C4C(F)(F)F,https://pubchem.ncbi.nlm.nih.gov/compound/11605744,PubChem,Cc1ccc(Nc2nc(Nc3ccc(C)cc3)c(N=Nc3ccccc3C(F)(F)F)c(C)c2C#N)cc1,Train,310,1,testing
+"US_HSDB:
+Ketamine",,6740-88-1,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/2180,,,US_HSDB,1,CNC1(CCCCC1=O)C2=CC=CC=C2Cl,https://pubchem.ncbi.nlm.nih.gov/compound/3821,PubChem,CNC1(c2ccccc2Cl)CCCCC1=O,Train,311,1,testing
+"EU_CLP:
+ethynyl cyclopropane",,6746-94-7,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C#CC1CC1,https://pubchem.ncbi.nlm.nih.gov/compound/138823,PubChem,C#CC1CC1,Test,312,1,testing
+"EU_REACH:
+methyl 5-amino-4-cyano-3-(2-methoxy-2-oxoethyl)thiophene-2-carboxylate",,674773-12-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7465/7/4/2/?documentUUID=afbfc8f6-0c64-4045-9bb3-cd89b6e61a5e,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)CC1=C(SC(=C1C#N)N)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/4962422,PubChem,COC(=O)Cc1c(C(=O)OC)sc(N)c1C#N,Train,313,2,testing
+"EU_REACH:
+methyl 5-[bis(2-methoxy-2-oxoethyl)amino]-4-cyano-3-(2-methoxy-2-oxoethyl)thiophene-2-carboxylate",,674773-13-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1349/7/4/2/?documentUUID=c5787410-abb6-4182-b3b3-efd47bb13285,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)CC1=C(SC(=C1C#N)N(CC(=O)OC)CC(=O)OC)C(=O)OC,https://pubchem.ncbi.nlm.nih.gov/compound/11516837,PubChem,COC(=O)Cc1c(C(=O)OC)sc(N(CC(=O)OC)CC(=O)OC)c1C#N,Train,313,2,testing
+"EU_REACH:
+6,6-dimethoxy-2,5,5-trimethylhex-2-ene",,67674-46-8,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20624/7/4/2/?documentUUID=99ad8896-039d-4fb2-9e61-178c281d5d5c,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=CCC(C)(C)C(OC)OC)C,https://pubchem.ncbi.nlm.nih.gov/compound/106766,PubChem,COC(OC)C(C)(C)CC=C(C)C,Train,314,2,testing
+"EU_CLP:
+2,4,4,7-tetramethyl-6-octen-3-one",,74338-72-0,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC(C)C(=O)C(C)(C)CC=C(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/9815427,PubChem,CC(C)=CCC(C)(C)C(=O)C(C)C,Test,314,2,testing
+"JP_CHRIP:
+Dimethyl sulfoxide","JP_CHRIP:
+DMSO
+Methyl sulphoxide",67-68-5,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-0023e.html,"JP_CHRIP:
+[Rationale for the Classification]
+Based on (1), it was classified as ""Not classified.""
+
+[Evidence Data]
+(1) In a skin irritation test with rabbits according to OECD TG 404, a very slight or well-defined erythema was observed, but all these disappeared within 72 hours (SIDS (2008), GESTIS (Access on September 2019), REACH registration dossier (Access on November 2019)).
+
+[Reference Data, etc.]
+(2) Skin irritation can develop at the site where this substance is applied topically (HSDB (Access on September 2019)).",Provided,JP_CHRIP,1,CS(=O)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.933J,J-GLOBAL,CS(C)=O,Train,315,1,testing
+"JP_CHRIP:
+methylphosphonic dichloride","JP_CHRIP:
+Methylphosphonic dichloride
+Methylphosphonic dichloride; Methylphosphonic dichloride",676-97-1,Cat 1,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-1090e.html,"JP_CHRIP:
+In Priority 2, the this product was very corrosiveness, and since there was description that the contact to the human skin causes a critical burned (SITTIG (4th, 2002)), it was set as Category 1A-1C. [view] It is more desirable to be set as Category 1A from a viewpoint of safety, when further categorizing needs to be performed.",,JP_CHRIP,1,CP(=O)(Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J50.316I,J-GLOBAL,CP(=O)(Cl)Cl,Train,316,1,testing
+"JP_CHRIP:
+hexamethylphosphoric triamide","JP_CHRIP:
+Hexamethylphosphamide
+Hexamethylphosphoramide
+HMPA
+phosphoric tris(N,N-dimethylamide)
+tris(dimethylamido)phosphate",680-31-9,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0930e.html,"JP_CHRIP:
+Based on description that there was severe irritation in the skin irritation test in guinea pigs (RTECS (2005)), and description that it might indicate irritation when the human skin were touched (HSFS (2001)), it was set as Category 2.",,JP_CHRIP,1,CN(C)P(=O)(N(C)C)N(C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.420B,J-GLOBAL,CN(C)P(=O)(N(C)C)N(C)C,Train,317,1,testing
+"EU_REACH:
+5(or 6)-methyl-7(or 8)-(1-methylethyl)bicyclo[2.2.2]oct-5-ene-2-carbaldehyde",,68259-31-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18521/7/4/2/?documentUUID=0c0919c3-b2d4-4744-89fe-3b9ce144d2ec,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=C2CC(C(C1)C(C2)C(C)C)C=O,https://pubchem.ncbi.nlm.nih.gov/compound/109261,PubChem,CC1=C2CC(C=O)C(C1)C(C(C)C)C2,Train,318,1,testing
+"JP_CHRIP:
+(5-Chloro-2-methoxy-4-methylpyridin-3-yl)(2,3,4-trimethoxy-6-methylphenyl)methanone; Pyriofenone",,688046-61-9,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0085e.html,"JP_CHRIP:
+[Rationale for the Classification]
+It was classified as ""Not classified"" from (1).
+
+[Evidence Data]
+(1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 72-hour observation), no skin irritation reactions were seen in any animal (erythema/eschar score: 0/0/0, edema score: 0/0/0) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2018), ECHA RAC Opinion (2019), CLH Report (2018), JMPR (2019), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2015)).",Provided,JP_CHRIP,1,O=C(C1=C(C)C(Cl)=CN=C1OC)C2=C(C)C=C(OC)C(OC)=C2OC,https://www.nite.go.jp/en/chem/chrip/chrip_search/cmpInfDsp?cid=C008-196-30A&slScNm=CI_01_001&bcPtn=3,CHRIP,COc1cc(C)c(C(=O)c2c(OC)ncc(Cl)c2C)c(OC)c1OC,Train,319,1,testing
+"JP_CHRIP:
+Tricyclo[5.2.1.0(2,6)]dec-4-enyl propionate",,68912-13-0,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0016e.html,"JP_CHRIP:
+[Rationale for the Classification]
+It was classified as ""Not classified"" from (1).
+
+[Evidence Data]
+(1) It is reported that in a skin irritation test with rabbits (n = 8) (equivalent to OECD TG 404, semi-occlusive, 4-hour application), no skin irritation was seen (erythema/eschar score: 0.67/0.67/1/1/0.67/0/0.67/1, edema score: 1/0.67/1/1/0.67/0/1/1.33) (REACH registration dossier (Accessed Aug. 2020)).",Provided,JP_CHRIP,1,CCC(=O)OC1C=CC2C3CCC(C3)C12,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J310.533D,J-GLOBAL,CCC(=O)OC1C=CC2C3CCC(C3)C12,Train,320,1,testing
+"EU_CLP:
+2,4,6-tri-n-propyl-2,4,6-trioxo-1,3,5,2,4,6-trioxatriphosphorinane",,68957-94-8,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CCCP1(=O)OP(=O)(OP(=O)(O1)CCC)CCC,https://pubchem.ncbi.nlm.nih.gov/compound/111923,PubChem,CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1,Test,321,1,testing
+"EU_REACH:
+methyl 2-[(4-amino-3,5-dichloro-6-fluoropyridin-2-yl)oxy]acetate",,69184-17-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13474/7/4/2/?documentUUID=d63a50aa-26e4-42ea-ba1e-3f3ca736adc7,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC(=O)COC1=NC(=C(C(=C1Cl)N)Cl)F,https://pubchem.ncbi.nlm.nih.gov/compound/5463802,PubChem,COC(=O)COc1nc(F)c(Cl)c(N)c1Cl,Train,322,1,testing
+"KR_NCIS:
+N,N'-Methanetetraylbis(2-propanamine)",,693-13-0,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CC(C)N=C=NC(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/12734,PubChem,CC(C)N=C=NC(C)C,Train,323,1,testing
+"KR_NCIS:
+5-Chloro-2,4,6-trifluoropyrimidine",,697-83-6,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C1(=C(N=C(N=C1F)F)F)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/69679,PubChem,Fc1nc(F)c(Cl)c(F)n1,Train,324,1,testing
+"EU_REACH:
+(1S,4R,6R)-1-[(3E)-5-hydroxy-3-methylpent-3-en-1-yn-1-yl]-2,2,6-trimethylcyclohexane-1,4-diol",,70905-68-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33700/7/4/2/?documentUUID=f4490d72-a892-408a-bd6a-a25bd971de37,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@@H]1C[C@H](CC([C@@]1(C#C/C(=C/CO)/C)O)(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/14631277,PubChem,C/C(C#C[C@]1(O)[C@H](C)C[C@@H](O)CC1(C)C)=C\CO,Train,325,1,testing
+"JP_CHRIP:
+Benzene
+
+KR_NCIS:
+Benzene
+
+NZ_CCID:
+Benzene
+
+US_HSDB:
+BENZENE","JP_CHRIP:
+benzene, pure
+Benzol
+Cyclohexatriene
+
+KR_NCIS:
+Benzol; Cyclohexatriene; Phenyl hydride; Benzine
+
+NZ_CCID:
+Benzol, Benzole, Coal naphtha, Cyclohexatriene, Phenyl hydride, Pyrobenzol, Pyrobenzole",71-43-2,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0191e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/79CB1318-1C4C-4F33-9E1F-5CDEF4152769
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/35","JP_CHRIP:
+Based on the description in the report on rabbit primary skin irritation tests (NICNAS (2001) and rabbit cumulative skin irritation tests (EHC 150 (1993)) as well as on EU Risk Phrase Xi; R36/38: Benzene is considered ""irritating"" to the skin.
+
+NZ_CCID:
+Skin Irritation
+SPECIES: Rabbit
+RESULT: Moderately irritating
+REFERENCE SOURCE: REPSOL PETROLEO,S.A. MADRID (508) Prehled Prumyslove Toxikologie; Organicke Latky; Marhold, J.; Prague, Czechoslovakia, Avicerum; 186, p.25 (1986)[IUCLID 2000]
+REMARK: EC Classification: Irritating
+Eye Irritation
+SPECIES: Rabbit
+RESULT: Moderate irritant
+REFERENCE SOURCE: Clayton, G.D., F.E. Clayton (eds.) Pattys Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994. 1318]**PEER REVIEWED**[HSDB]",,"JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",4,c1ccccc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.375B,J-GLOBAL,c1ccccc1,Train,326,1,testing
+"EU_REACH:
+2-[2-(3-butoxypropyl)-1,1-dioxo-2H-1lambda6,2,4-benzothiadiazin-3-yl]-N-{5-tert-butyl-2-[(2-ethylhexyl)sulfanyl]phenyl}-2-(5,5-dimethyl-2,4-dioxo-1,3-oxazolidin-3-yl)acetamide",,727678-39-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/3364/7/4/2/?documentUUID=6b87b89e-47a3-4b00-90ed-65aa7497b352,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCC(CC)CSC1=C(C=C(C=C1)C(C)(C)C)NC(=O)C(C2=NC3=CC=CC=C3S(=O)(=O)N2CCCOCCCC)N4C(=O)C(OC4=O)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/20778516,PubChem,CCCCOCCCN1C(C(C(=O)Nc2cc(C(C)(C)C)ccc2SCC(CC)CCCC)N2C(=O)OC(C)(C)C2=O)=Nc2ccccc2S1(=O)=O,Train,327,1,testing
+"EU_REACH:
+6-(methylsulfanyl)-N2,N4-di(propan-2-yl)-1,3,5-triazine-2,4-diamine
+
+JP_CHRIP:
+2,4-Bis(isopropylamino)-6-(methylthio)-s-triazine; N,N'-Diisopropyl-6-(methylthio)-1,3,5-triazine-2,4-diamine; Prometryn","JP_CHRIP:
+1,3,5-Triazine-2,4-diamine, N,N'-bis(1-methylethyl)-6-(methylthio)-
+Acetamide, 2-chloro-N-(2,6-diethylphenyl)-N-(methoxymethyl)-",7287-19-6,NC,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/32336/7/4/2/?documentUUID=d5b4db3b-3da9-4c99-ab66-f135f27eb368
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0030e.html","EU_REACH:
+Experimental study (OECD TG 404, GLP)
+
+JP_CHRIP:
+[Rationale for the Classification]
+It was classified as ""Not classified"" from (1), (2) in accordance with the GHS classification guidance for the Japanese government.
+
+[Evidence Data]
+(1) Slight skin irritation was observed in a skin irritation test with rabbits (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2015)).
+(2) Slight irritation was seen in a skin irritation test with rabbits (EPA Pesticide RED (1996), HSDB (Accessed Sep. 2020)).",Provided,"EU_REACH, JP_CHRIP",2,CSc1nc(NC(C)C)nc(NC(C)C)n1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.096A,J-GLOBAL,CSc1nc(NC(C)C)nc(NC(C)C)n1,Train,328,2,testing
+"JP_CHRIP:
+2-ethylamino-4-isopropylamino-6-methylthio-1,3,5-triazine; Ametryn","JP_CHRIP:
+1,3,5-Triazine-2,4-diamine, N-ethyl-N'-(1-methylethyl)-6-(methylthio)-
+2-ethylamino-4-isopropylamino-6-methylthio-1,3,5-trizaine [synonym:Ametryne]
+N-ethyl-N'-isopropyl-6-methylthio-1,3,5-trizaine-2,4-diamine (synonym:2-ethylamino-4-isopropylamino-6-methylthio-1,3,5-trizaine or Ametryne)",834-12-8,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2096e.html,"JP_CHRIP:
+[Rationale for the Classification]
+It was classified as ""Not classified"" (corresponding to Category 3 in UN GHS classification) from (1) - (4).
+
+[Evidence Data]
+(1) In a skin irritation test with rabbits according to EPA OPPTS 870.2500, it was judged as not an irritant (EPA Pesticides RED (2005)).
+(2) In eye and skin irritation tests with rabbits, this substance was judged as negative by the US EPA but as slightly irritating by APVMA, Australia (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2007)).
+(3) It is reported that this substance was slightly irritating to the skin of rabbits (Patty (6th, 2012)).
+(4) In a skin irritation test with rabbits according to OECD TG 404 on this substance, very slight erythema was noted one hour after patch removal but disappeared within 24 hours (REACH registration dossier (Access on September 2020)).
+
+[Reference Data, etc.]
+(5) In a skin irritation test with rabbits on a formulation of this substance (emulsion), slight irritation was observed, erythema disappeared after 14 days, and edema disappeared by day 4 (Japanese Journal of Pesticide Science Vol. 18, No. 4 (Pesticide Science Society of Japan, 1993)).
+(6) In a skin irritation test with rabbits on a formulation of this substance (wettable powder), no irritation was found (Japanese Journal of Pesticide Science Vol. 18, No. 4 (Pesticide Science Society of Japan, 1993)).",Provided,JP_CHRIP,1,CCNc1nc(NC(C)C)nc(SC)n1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.651J,J-GLOBAL,CCNc1nc(NC(C)C)nc(SC)n1,Train,328,2,testing
+"EU_REACH:
+[2,5-dioxo-3-(prop-2-yn-1-yl)imidazolidin-1-yl]methyl (1R,3R)-2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxylate; [2,5-dioxo-3-(prop-2-yn-1-yl)imidazolidin-1-yl]methyl (1R,3S)-2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxylate",,72963-72-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/33131/7/4/2/?documentUUID=6499f488-a698-475f-97f0-2dd6846b4cc4,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=CC1C(C1(C)C)C(=O)OCN2C(=O)CN(C2=O)CC#C)C,https://pubchem.ncbi.nlm.nih.gov/compound/123622,PubChem,C#CCN1CC(=O)N(COC(=O)C2C(C=C(C)C)C2(C)C)C1=O,Train,329,1,testing
+"JP_CHRIP:
+tolylfluanid (ISO); dichloro-N-[(dimethylamino)sulphonyl]fluoro-N-(p-tolyl)methanesulphenamide
+
+KR_NCIS:
+Tolylfluanid
+
+NZ_CCID:
+Tolylfluanid","KR_NCIS:
+Dichloro-N-[(dimethylamino)sulfonyl]fluoro-N-(p-tolyl)methanesulfenamide
+
+NZ_CCID:
+Dichloro-N-((dimethylamino)sulphonyl)fluoro-N-(p-tolyl)methanesulphenamidetolyl)methanesulphenamide, Sulfamide, N-((dichlorofluoromethyl)thio)-N,N-dimethyl-N-(p-tolyl)-",731-27-1,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0208e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BDD2F169-ED2C-4108-A3CE-FD71F8D0C7F8","JP_CHRIP:
+Two tests have been conducted using rabbits; one test concluded that the substance was severely irritating (JMPR (2002)) and the other test found that it caused no irritation (using 1% water solution) (JMPR (2002)). Considering that the EU rated the substance as Xi; R36/37/38, it was classified into Category 2.
+
+NZ_CCID:
+Skin Irritation
+R-PHRASE: R 38 Irritating to skin. [NCLASS]
+Eye Irritation
+R-PHRASE: R 36 Irritating to Eyes. [NCLASS]",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,CN(C)S(=O)(=O)N(SC(F)(Cl)Cl)c1ccc(C)cc1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J6.957D,J-GLOBAL,Cc1ccc(N(SC(F)(Cl)Cl)S(=O)(=O)N(C)C)cc1,Train,330,1,testing
+"EU_REACH:
+L-tryptophan",,73-22-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10835/7/4/2/?documentUUID=53310c87-8d20-45e9-a413-5072e34b1be5,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)N,https://pubchem.ncbi.nlm.nih.gov/compound/6305,PubChem,N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O,Train,331,1,testing
+"EU_REACH:
+7,13-dicyclohexyl-5,15-dimethyl-9,11-dioxa-10-phosphatricyclo[10.4.0.0³,⁸]hexadeca-1(12),3(8),4,6,13,15-hexaen-10-ol",,73912-21-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23944/7/4/2/?documentUUID=757ef9b7-af8b-433f-834b-e6a1055ffc4a,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC2=C(C(=C1)C3CCCCC3)OP(OC4=C(C2)C=C(C=C4C5CCCCC5)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/166434,PubChem,Cc1cc2c(c(C3CCCCC3)c1)OP(O)Oc1c(cc(C)cc1C1CCCCC1)C2,Train,332,1,testing
+"EU_REACH:
+7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one",,73942-87-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8045/7/4/2/?documentUUID=b8aaf6c9-883e-4be8-b46f-5474c19886d3,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,COC1=C(C=C2C=CNC(=O)CC2=C1)OC,https://pubchem.ncbi.nlm.nih.gov/compound/1482373,PubChem,COc1cc2c(cc1OC)CC(=O)NC=C2,Test,333,1,testing
+"EU_CLP:
+diethylmethoxyborane",,7397-46-8,Cat 1,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,B(CC)(CC)OC,https://pubchem.ncbi.nlm.nih.gov/compound/522516,PubChem,CCB(CC)OC,Test,334,1,testing
+"EU_CLP:
+morfamquat (ISO); 1,1'-bis(3,5-dimethylmorpholinocarbonylmethyl)-4,4'-bipyridilium ion",,7411-47-4,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC1COCC(N1C(=O)C[N+]2=CC=C(C=C2)C3=CC=[N+](C=C3)CC(=O)N4C(COCC4C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/107851,PubChem,CC1COCC(C)N1C(=O)C[n+]1ccc(-c2cc[n+](CC(=O)N3C(C)COCC3C)cc2)cc1,Test,335,1,testing
+"EU_REACH:
+5,5'-{ethane-1,2-diylbis[thio-1,3,4-thiadiazole-5,2-diyldiazene-2,1-diyl(5-amino-3-tert-butyl-1H-pyrazole-4,1-diyl)]}diisophthalic acid",,741248-63-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21051/7/4/2/?documentUUID=ea91a847-0941-4ca6-9eaa-e6d97a4cede5,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C1=NN(C(=C1N=NC2=NN=C(S2)SCCSC3=NN=C(S3)N=NC4=C(N(N=C4C(C)(C)C)C5=CC(=CC(=C5)C(=O)O)C(=O)O)N)N)C6=CC(=CC(=C6)C(=O)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/136500903,PubChem,CC(C)(C)c1nn(-c2cc(C(=O)O)cc(C(=O)O)c2)c(N)c1N=Nc1nnc(SCCSc2nnc(N=Nc3c(C(C)(C)C)nn(-c4cc(C(=O)O)cc(C(=O)O)c4)c3N)s2)s1,Train,336,1,testing
+"EU_REACH:
+N-[3,5-bis(2,2-dimethylpropanamido)phenyl]-2,2-dimethylpropanamide",,745070-61-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10725/7/4/2/?documentUUID=00c1f6a2-2c74-417a-9830-61eb2eb1e5ae,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C)C(=O)NC1=CC(=CC(=C1)NC(=O)C(C)(C)C)NC(=O)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/53421640,PubChem,CC(C)(C)C(=O)Nc1cc(NC(=O)C(C)(C)C)cc(NC(=O)C(C)(C)C)c1,Train,337,1,testing
+"JP_CHRIP:
+Methyl bromide
+
+KR_NCIS:
+Methyl bromide
+
+US_HSDB:
+Methyl bromide","JP_CHRIP:
+Methyl bromide
+Methane, bromo-
+Methyl bromide
+Monobromomethane
+
+KR_NCIS:
+Bromomethane; Monobromomethane; Embafume; MeBr",74-83-9,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2093e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/779","JP_CHRIP:
+Since there are a number of case reports describing skin irritation (ACGIH (7th, 2001), ATSDR (1992), SIDS (2002)), the substance was classified into Category 2. In a test where the substance (liquid) was applied to the back of rabbits, very slight erythema was observed in 1/6 animals within 24-hour, which disappeared within 48-hour (Test Data for Supporting Registration of Pesticides (1979)). Application of the substance to the back of rats led to the impairments to the epidermal cells and consequently necrosis (HSDB (2002)). In EU classification, the substance is classified into Xi; R38.",,"JP_CHRIP, KR_NCIS, US_HSDB",3,CBr,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.381G,J-GLOBAL,CBr,Train,338,1,testing
+"AU_HCIS:
+methyl iodide
+
+JP_CHRIP:
+Methyl iodine
+
+KR_NCIS:
+Methyl iodide
+
+NZ_CCID:
+Iodomethane","AU_HCIS:
+iodomethane
+Methane, iodo-
+
+JP_CHRIP:
+Methyl iodide
+Iodomethane
+
+KR_NCIS:
+Iodomethane
+
+NZ_CCID:
+Methane, iodo-, Methyl iodide, Methyliodide, Monoiodomethane",74-88-4,Cat 2,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=2916
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2132e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5DF328E9-782D-46FF-B56A-F7B3F27F8C3D","JP_CHRIP:
+There is a description that in a skin irritation test in which 0.5 mL of this substance was semi-occlusively applied to rabbits for 4 hours, the primary irritation index was 4.88, and it was moderately irritating (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). In addition, there is a report that erythema with vesicles was observed after 19 hours when 1 mL of this substance was applied to the skins of humans for 30 minutes (IARC 15 (1977)). From the above results, it was classified in Category 2. Besides, this substance was classified as ""Xi; R38'' in the EU DSD classification and as ""skin Irrit. 2 H315'' in the EU CLP classification.
+
+NZ_CCID:
+Skin Irritation
+SPECIES: New Zealand White rabbit
+RESULT: The Primary Irritation Indices (PIIs) were 3.58, 4.25 and 4.88 for the 3 minute, 1 and 4 hour exposures respectively.
+RELIABILITY (KLIMISCH SCORE): 1 (2001, OECD 404, GLP)
+Eye Irritation
+SPECIES: New Zealand White rabbit
+RESULT (mean 24-72hr scores):
+overall irritation score Cornea: 2 (fully reversible within: 21 days in 4/6 animals)
+overall irritation score Iris: 1.1 (fully reversible within: 21 days in all animals)
+overall irritation score conjunctiva - redness: 2.4 (fully reversible within: 21 days in 2/6 animals)
+overall irritation score conjunctiva - chemosis: 2.2 (fully reversible within: 21 days in 3/6 animals)
+RELIABILITY (KLIMISCH SCORE): 1 (2001,OECD 405, GLP)",Provided,"AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID",4,CI,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.382E,J-GLOBAL,CI,Train,339,1,testing
+"JP_CHRIP:
+Methylamine
+
+KR_NCIS:
+Methylamine; Methanamine, Monomethylamine
+
+NZ_CCID:
+Methanamine (methylamine)
+
+US_HSDB:
+Methylamine","JP_CHRIP:
+Aminomethane
+Methanamine
+methylamine, in aqueous solution
+Monomethylamine
+
+NZ_CCID:
+Aminomethane, Carbinamine, Methanamine, Methylamine, Monomethylamine, R630",74-89-5,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-meti-2004e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4C777067-A395-4629-A8BA-64F4B178F458
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/810","JP_CHRIP:
+Although there is no data of skin irritation test with this substance (gas), the solution seems to have a skin corrosion from descriptions that 40% solution causes a necrosis on skin of rabbits (Patty (5th, 2001)) and that ""40% solution causes a necrosis on skin of guinea pig 40%"" (ACGIH (7th, 2001)). It was classified as Category 1with unknown further data and without subdivision. In addition, a solution with 10% or more of this substance concentration can be classified as R34 in the EU classification (EU-Annex I).
+
+NZ_CCID:
+Skin Irritation
+SPECIES: Guinea Pig
+RESULT: Corrosive
+REFERENCE SOURCE: Goffman T, Maguire JR HC; Contact dermatitis 6(2): 140-1 (1980) **PEER REVIEWED** [HSDB]
+Eye Irritation
+SPECIES: Rabbit
+RESULT: Corrosive
+REFERENCE SOURCE: Clayton, G.D., F.E. Clayton (eds.) Pattys Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994. 1105 **PEER REVIEWED** [HSDB]",,"JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB",4,CN,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.431A,J-GLOBAL,CN,Train,340,1,testing
+"NZ_CCID:
+Boron hydride-trimethylamine",,75-22-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/580D0AAB-4AEB-46ED-9509-5A03BAC5E907,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,B[N+](C)(C)C,https://cactus.nci.nih.gov/chemical/structure/75-22-9/smiles,CACTUS,B[N+](C)(C)C,Train,341,1,testing
+"JP_CHRIP:
+Tribromomethane
+
+NZ_CCID:
+Bromoform
+
+US_HSDB:
+Bromoform","JP_CHRIP:
+Methane, tribromo-
+Methenyl tribromide
+Tribromomethane
+
+NZ_CCID:
+Methane, tribromo-, Methenyl tribromide, Tribromomethane",75-25-2,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2065e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7D3BCFE2-0A70-4337-882F-916E77255EBF
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/2517","JP_CHRIP:
+Based on the description that irritation of the skin was seen in humans (Initial Risk Assessment (NITE, CERI, NEDO, 2007)), and the description that in a skin irritation test with rabbits, it showed moderate irritation (PATTY (6th, 2012)), this substance was classified in Category 2.
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,"JP_CHRIP, NZ_CCID, US_HSDB",3,BrC(Br)Br,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.446J,J-GLOBAL,BrC(Br)Br,Train,342,2,testing
+"JP_CHRIP:
+1,1,2,2-tetrabromoethane","JP_CHRIP:
+Acetylene tetrabromide
+sym-Tetrabromoethane
+Tetrabromoacetylene",79-27-6,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2001e.html,"JP_CHRIP:
+[Rationale for the Classification]
+It was classified in Category 2 from (1) - (3).
+
+[Evidence Data]
+(1) This substance is an eye and skin irritant in exposed workers, and direct contact with the skin can cause blistering (ACGIH (7th, 2019)).
+(2) This substance is irritating to the mucosa and skin (GESTIS (Access on April 2020)).
+(3) In experiments with rabbits, an open application does not cause irritation, but after occlusive application, slight erythema was seen, and edema and blistering were observed after 24 hours, but ordinary contact does not represent a skin problem (Patty (6th, 2012)).",,JP_CHRIP,1,BrC(Br)C(Br)Br,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.838E,J-GLOBAL,BrC(Br)C(Br)Br,Train,342,2,testing
+"EU_REACH:
+(S)-pyrrolidine-2-carboxamide",,7531-52-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25124/7/4/2/?documentUUID=1e3ecb2c-81f0-4ac4-8185-39c9412dc9a4,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C[C@H](NC1)C(=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/111306,PubChem,NC(=O)[C@@H]1CCCN1,Train,343,1,testing
+"JP_CHRIP:
+Iodoform
+
+NZ_CCID:
+Iodoform","NZ_CCID:
+Carbon triiodide, Methane, triiodo-, Triiodomethane",75-47-8,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2057e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/40193963-1A09-4684-92BD-260302EA9179","JP_CHRIP:
+[Rationale for the Classification]
+Based on (1), it was classified in Category 2. The category was changed due to the new data obtained.
+
+[Evidence Data]
+(1) This substance is irritating to the skin, eyes and mucous membranes (PATTY (6th, 2012)).
+
+[Reference Data, etc.]
+(2) Iodine may be an irritant, and it may be corrosive depending on the concentration or duration of the contact (HSDB (Access on July 2019)).
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 38
+[The Physical and Theoretical Chemistry Laboratory Oxford University Chemical and Other Safety Information, Safety (MSDS) data for iodoform, http://physchem.ox.ac.uk/MSDS/IO/iodoform.html]
+Eye Irritation
+R PHRASE: R 36
+[The Physical and Theoretical Chemistry Laboratory Oxford University Chemical and Other Safety Information, Safety (MSDS) data for iodoform, http://physchem.ox.ac.uk/MSDS/IO/iodoform.html]",,"JP_CHRIP, NZ_CCID",2,IC(I)I,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.456G,J-GLOBAL,IC(I)I,Train,344,1,testing
+"EU_REACH:
+4-methyl-1H-pyrazole",,7554-65-6,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7666/7/4/2/?documentUUID=7337caee-ea6c-4990-90bf-12bab3c74734,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CNN=C1,https://pubchem.ncbi.nlm.nih.gov/compound/3406,PubChem,Cc1cn[nH]c1,Test,345,1,testing
+"EU_REACH:
+616-307-3",,76205-19-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27100/7/4/2/?documentUUID=f1cd3aee-6590-4a76-8280-f69d1845acc2,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC(=CC=C1N2C=CC(=O)N2)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/11356026,PubChem,O=c1ccn(-c2ccc(Cl)cc2)[nH]1,Train,346,1,testing
+"NZ_CCID:
+Phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis[5-methyl-2-(1-methylethyl)-",,76-61-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7E837472-D575-4973-9B0E-01231CCC253B,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company data].
+Eye Irritation
+R PHRASE: R 36 [Company data].",,NZ_CCID,1,CC1=CC(=C(C=C1C2(C3=CC=CC=C3S(=O)(=O)O2)C4=CC(=C(C=C4C)O)C(C)C)C(C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/65565,PubChem,Cc1cc(O)c(C(C)C)cc1C1(c2cc(C(C)C)c(O)cc2C)OS(=O)(=O)c2ccccc21,Train,347,1,testing
+"EU_CLP:
+(2S,5R)-6,6-dibromo-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide",,76646-91-8,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC1([C@@H](N2[C@H](S1(=O)=O)C(C2=O)(Br)Br)C(=O)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/1427720,PubChem,CC1(C)[C@H](C(=O)O)N2C(=O)C(Br)(Br)[C@H]2S1(=O)=O,Test,348,1,testing
+"EU_REACH:
+2-(4-{4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butanoyl}phenyl)-2-methylpropanoic acid",,76811-98-8,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6505/7/4/2/?documentUUID=0d63ea2e-b63c-4474-b6a0-50146e9544ba,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/9935699,PubChem,CC(C)(C(=O)O)c1ccc(C(=O)CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,Train,349,2,testing
+"EU_REACH:
+2-(4-{4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]but-1-yn-1-yl}phenyl)-2-methylpropanoic acid",,832088-68-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5722/7/4/2/?documentUUID=48aa4e51-b9f8-4b64-893c-eafb17e46bcc,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C1=CC=C(C=C1)C#CCCN2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O)C(=O)O,https://pubchem.ncbi.nlm.nih.gov/compound/11982796,PubChem,CC(C)(C(=O)O)c1ccc(C#CCCN2CCC(C(O)(c3ccccc3)c3ccccc3)CC2)cc1,Train,349,2,testing
+"NZ_CCID:
+Famotidine",,76824-35-6,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AE07BBAD-65BD-4988-940A-F428FD3B1A89,"NZ_CCID:
+Skin Irritation
+REMARK: Confidential information supplied by registrant
+Eye Irritation
+REMARK: Confidential information supplied by registrant",,NZ_CCID,1,C1=C(N=C(S1)N=C(N)N)CSCCC(=NS(=O)(=O)N)N,https://pubchem.ncbi.nlm.nih.gov/compound/3325,PubChem,NC(N)=Nc1nc(CSCCC(N)=NS(N)(=O)=O)cs1,Train,350,1,testing
+"JP_CHRIP:
+2-Amino-4-[hydroxy(methyl)phosphoryl]butanoic acid,ammonium salt; Glufosinate-ammonium",,77182-82-2,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-0007e.html,"JP_CHRIP:
+[Rationale for the Classification]
+It was classified as ""Not classified"" from (1), (2).
+
+[Evidence Data]
+(1) In skin irritation tests with rabbits on this substance by 24-hour semi-occlusive application or by methods according to OECD TG 404, only erythema was observed in part of the animals, and it was judged as not irritating (JMPR (2012), Japan Crop Protection Association Fed. Chem. Toxic. vol.28 no.5 (1990)).
+(2) No irritation was observed in an eye irritation test and a skin irritation test with rabbits on this substance (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2013), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2011)).",Provided,JP_CHRIP,1,CP(=O)(O)CCC(N)C(=O)O[N+],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J309.363H,J-GLOBAL,CP(=O)(O)CCC(N)C(=O)O[N+],Train,351,1,testing
+"JP_CHRIP:
+Hexachlorocyclopentadiene
+
+KR_NCIS:
+Hexachlorocyclopentadiene","JP_CHRIP:
+1,2,3,4,5,5-Hexachloro-1,3-cyclopentadiene
+1,2,3,4,5,5-Hexachlorocyclopenta-1,3-diene
+HCCPD
+Hexachlorocyclopentadiene
+Perchlorocyclopentadiene
+
+KR_NCIS:
+Perchlorocyclopentadiene; Hexachloro-1,3-cyclopentadiene; 1,2,3,4,5,5-Hexachloro-1,3-Cyclopentadiene; Graphlox",77-47-4,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2086e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""","JP_CHRIP:
+In a skin irritation test with rabbits, it was found corrosive in tests in which the undiluted liquid or a 10% aqueous solution of this substance was applied (EU-RAR (2007)). In addition, there are reports that it was also found corrosive in a test in which 40-90% aqueous solutions of this substance were applied to guinea pigs (EU-RAR (2007)) and that there was moderate to severe primary irritation on rabbit skin (EHC 120 (1991)). In humans, there is a report that it was irritating to the skin (IRIS (2001), EU-RAR (2007)). From the above, based on the ""corrosive"" results in rabbits, it was classified in Category 1. Besides, this substance was classified in ""C; R34"" in the EU DSD classification, in ""Skin Corr. 1B H314"" in the EU CLP classification. Information was added, and the category was changed.",,"JP_CHRIP, KR_NCIS",2,ClC1=C(Cl)C(Cl)(Cl)C(=C1Cl)Cl,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.949F,J-GLOBAL,ClC1=C(Cl)C(Cl)(Cl)C(Cl)=C1Cl,Train,352,1,testing
+"EU_REACH:
+2-methylprop-1-ene",,7756-94-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5319/7/4/2/?documentUUID=6faff624-dd19-4b52-8885-d83a809ec126,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(=CC(C)(C)CC(C)(C)C)C,https://pubchem.ncbi.nlm.nih.gov/compound/170244,PubChem,CC(C)=CC(C)(C)CC(C)(C)C,Train,353,1,testing
+"EU_REACH:
+3a,4,7,7a-tetrahydro-1H-4,7-methanoindene
+
+JP_CHRIP:
+Dicyclopentadiene
+
+NZ_CCID:
+4,7-Methano-1H-indene, 3a,4,7,7a-tetrahydro-
+
+US_HSDB:
+DICYCLOPENTADIENE","JP_CHRIP:
+1,3-Dicyclopentadiene
+3a,4,7,7a-Tetrahydro-4,7-methano-1H-indene
+3a,4,7,7a-tetrahydro-4,7-methanoindene
+Dicyclopentadiene
+tricyclo[5,2,1,0(2,6)]deca-3,8-diene
+
+NZ_CCID:
+Bicyclopentadiene, Biscyclopentadiene, 3a,4,7,7a-Tetrahydro-4,7-methanoindene, 4,7-Methanoindene, 3a,4,7,7a-tetrahydro-, Cyclopentadiene dimer, Dicyclopentadiene",77-73-6,Cat 2,"EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15412/7/4/2/?documentUUID=867b7e3f-2973-4278-8e23-6d094dcb9a01
+JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2054e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/72E9FB8F-3609-42D2-8104-7C6D56F50B1E
+US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/321","EU_REACH:
+Experimental study (OECD TG 404, GLP)
+
+JP_CHRIP:
+Based on a report that it was moderately irritating in a skin irritation test with rabbits (ECETOC JACC 19 (1991)), it was classified in Category 2. Besides, this substance is classified in ""Skin Irrit. 2"" in the EU CLP classification (ECHA CL Inventory (Access on June 2017)).
+
+NZ_CCID:
+Skin Irritation
+SPECIES: Rabbit
+RESULT: Moderately irritating
+REFERENCE SOURCE: Dow Benelux N. V. Terneuzen
+Test substance: 75 %iges DCPD (28) Jones, J.R. (1989): Dow Europe Report 1228. (IUCLID 2000)
+R-PHRASE: R 36/37/38 Irritating to eyes, respiratory system and skin. [IUCLID 2000]
+Eye Irritation
+SPECIES: Rabbit
+RESULT: Irritating
+REFERENCE SOURCE: Dicyclopentadien : Anonymous : TA:Toxikologische Bewertung. Heidelberg, Berufsgenossenschaft der chemischen Industrie PG:31 p YR:1994 IP: VI:84
+[TOXLINE]",Provided,"EU_REACH, JP_CHRIP, NZ_CCID, US_HSDB",4,C1C=CC2C3CC(C=C3)C12,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J9.241J,J-GLOBAL,C1=CC2C3C=CC(C3)C2C1,Train,354,1,testing
+"JP_CHRIP:
+Divinyl sulfone
+
+NZ_CCID:
+Divinyl sulphone","JP_CHRIP:
+Divinyl sulfone
+
+NZ_CCID:
+vinyl sulfone",77-77-0,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0143e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/497E866C-E77A-4D92-AA8F-953927ECFC90","JP_CHRIP:
+The substance was classified as Category 1 based on the document that application of the substance to rabbit skin caused necrosis (PATTY, 5th (2001)).
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,"JP_CHRIP, NZ_CCID",2,C=CS(=O)(=O)C=C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.478H,J-GLOBAL,C=CS(=O)(=O)C=C,Train,355,1,testing
+"US_HSDB:
+Okadaic acid",,78111-17-8,Cat 2,US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/7243,,,US_HSDB,1,CC1CCC2(CCCCO2)OC1C(C)CC(C3C(=C)C(C4C(O3)CCC5(O4)CCC(O5)C=CC(C)C6CC(=CC7(O6)C(CCC(O7)CC(C)(C(=O)O)O)O)C)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/4584,PubChem,C=C1C(O)C2OC3(CCC(C=CC(C)C4CC(C)=CC5(OC(CC(C)(O)C(=O)O)CCC5O)O4)O3)CCC2OC1C(O)CC(C)C1OC2(CCCCO2)CCC1C,Train,356,1,testing
+"AU_HCIS:
+Urea, N-[1,3-bis(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N'-bis(hydroxymethyl)-",,78491-02-8,Cat 2,AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5045,,,AU_HCIS,1,C(NC(=O)N(CO)C1C(=O)N(C(=O)N1CO)CO)O,https://pubchem.ncbi.nlm.nih.gov/compound/62277,PubChem,O=C1C(N(CO)C(=O)NCO)N(CO)C(=O)N1CO,Train,357,1,testing
+"EU_REACH:
+(±)-dihydro-3-hydroxy-4,4-dimethylfuran-2(3H)-one",,79-50-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16642/7/4/2/?documentUUID=81b9200f-89a9-4c5e-b6fb-6ba65fd0033b,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1(COC(=O)C1O)C,https://pubchem.ncbi.nlm.nih.gov/compound/989,PubChem,CC1(C)COC(=O)C1O,Train,358,1,testing
+"EU_REACH:
+2,4-diazatetracyclo[12.4.0.0²,⁶.0⁷,¹²]octadeca-1(18),3,7,9,11,14,16-heptaen-3-amine",,80012-43-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25792/7/4/2/?documentUUID=d0ac4fe9-387a-4fbb-9ea5-a1289b3a52e5,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C2C3=CC=CC=C3CC4=CC=CC=C4N2C(=N1)N,https://pubchem.ncbi.nlm.nih.gov/compound/3241,PubChem,NC1=NCC2c3ccccc3Cc3ccccc3N12,Train,359,1,testing
+"KR_NCIS:
+Camphechlor","KR_NCIS:
+Toxaphene",8001-35-2,Cat 2,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,C=C1C(C2(C(C(C1(C2(Cl)Cl)Cl)Cl)Cl)Cl)(CCl)CCl,https://pubchem.ncbi.nlm.nih.gov/compound/5284469,PubChem,C=C1C(CCl)(CCl)C2(Cl)C(Cl)C(Cl)C1(Cl)C2(Cl)Cl,Train,360,1,testing
+"EU_REACH:
+5-methyl-2-(1-methylbutyl)-5-propyl-1,3-dioxane",,80480-24-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/22456/7/4/2/?documentUUID=c8c446cf-9483-4031-b80c-1a4e54914855,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC(C)C1OCC(CO1)(C)CCC,https://pubchem.ncbi.nlm.nih.gov/compound/166523,PubChem,CCCC(C)C1OCC(C)(CCC)CO1,Train,361,1,testing
+"EU_CLP:
+sabadilla (ISO); veratrine",,8051-02-3,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C/C=C(/C)\C(=O)O[C@H]1CC[C@]2([C@H]3[C@@]1(O[C@@]24C[C@]5([C@@H]6CN7C[C@H](CC[C@H]7[C@@]([C@]6([C@H](C[C@]5([C@@H]4CC3)O)O)O)(C)O)C)O)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/5380394,PubChem,C/C=C(/C)C(=O)O[C@H]1CC[C@@]2(C)[C@@H]3CC[C@H]4[C@]5(O)C[C@H](O)[C@@]6(O)[C@@H](CN7C[C@@H](C)CC[C@H]7[C@@]6(C)O)[C@]5(O)C[C@@]42O[C@]13O,Test,362,1,testing
+"EU_REACH:
+2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide",,81-13-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14227/7/4/2/?documentUUID=55f4d317-ac75-44ca-839b-a685c2fed021,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(CO)[C@H](C(=O)NCCCO)O,https://pubchem.ncbi.nlm.nih.gov/compound/131204,PubChem,CC(C)(CO)[C@@H](O)C(=O)NCCCO,Train,363,1,testing
+"NZ_CCID:
+Cholic acid",,81-25-4,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FEAF5926-D19A-4F24-B514-8374A13D4302,"NZ_CCID:
+Skin Irritation
+REMARK: Confidential information supplied by registrant
+Eye Irritation
+REMARK: Confidential information supplied by registrant",,NZ_CCID,1,C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2[C@@H](C[C@H]4[C@@]3(CC[C@H](C4)O)C)O)O)C,https://pubchem.ncbi.nlm.nih.gov/compound/221493,PubChem,C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C,Train,364,1,testing
+"EU_REACH:
+(2S,4S)-4-(phenylsulfanyl)pyrrolidine-2-carboxylic acid",,81653-77-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1157/7/4/2/?documentUUID=b46de39b-cf30-4686-8289-615dfa0648dc,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1[C@@H](CN[C@@H]1C(=O)O)SC2=CC=CC=C2,https://pubchem.ncbi.nlm.nih.gov/compound/11379084,PubChem,O=C(O)[C@@H]1C[C@H](Sc2ccccc2)CN1,Train,365,1,testing
+"JP_CHRIP:
+N-[3-(1-ethyl-1-methylpropyl)-1,2-oxazol-5-yl]-2,6-dimethoxybenzamide","JP_CHRIP:
+Isoxaben",82558-50-7,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0297e.html,"JP_CHRIP:
+In topical tests using rats (50%-concentration formulation, 4-hour application), the following were observed: erythema in all treated animals, encrustation in four animals, and mild edema in one animal (Pesticide Safety Information (Japan Crop Protection Association) No.18 (1995)). Based on these results, the substance was classified into Category 2.",,JP_CHRIP,1,CCC(C)(CC)c1cc(NC(=O)c2c(OC)cccc2OC)on1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J20.623G,J-GLOBAL,CCC(C)(CC)c1cc(NC(=O)c2c(OC)cccc2OC)on1,Train,366,1,testing
+"JP_CHRIP:
+2,2,6,6-Tetramethylpiperidin-4-one
+
+NZ_CCID:
+2,2,6,6-Tetramethyl-4-piperidone","JP_CHRIP:
+2,2,6,6-Tetramethyl-4-oxopiperidine
+4-Piperidinone, 2,2,6,6-tetramethyl-",826-36-8,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0139e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0E9138E5-310A-49E1-A6F0-8DDB3429A025","JP_CHRIP:
+On the basis that a test (OECD TG 404) applied 500 mg to rabbit skin for 4 hours observed severe necrosis was discontinued due to severe damages after 24 hours and this substance was assessed as caustic as a result (BUA Report 255 (2006)), it was classified in Category 1.
+Furthermore, another test applied 500 mg to only a rabbit (OECD TG 404) was discontinued due to severe necrosis after 72 hours (BUA Report 255 (2006)), and it was also assessed as caustic.
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",Provided,"JP_CHRIP, NZ_CCID",2,CC1(C)CC(=O)CC(C)(C)N1,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J107D,J-GLOBAL,CC1(C)CC(=O)CC(C)(C)N1,Train,367,1,testing
+"JP_CHRIP:
+Rotenone
+
+KR_NCIS:
+Rotenone
+
+NZ_CCID:
+Rotenone","JP_CHRIP:
+[1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, [2R-(2alpha,6aalpha,12aalpha)]-
+Derris powder
+Tubotoxine
+
+KR_NCIS:
+(2R,6aS,12aS)-1,2,6,6a,12,12a-Hexahydro-2-isopropenyl-8,9-dimethoxychromeno[3,4-b]furo[2,3-h]chromen-6-one; (2R,6aS,12aS)-1,2,6,6a,12,12a-Hexahydro-2-isopropenyl-8,9-dimethoxychromenol[3,4b]furo[2,3-h]chromen-6-one; [1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-2a-isopropenyl-8,9-dimethoxy-; [1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, (2R,6aS,12aS)-; [1]Benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one, 1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-, [2R-(2a,6aa,12aa)]-; 1,2,12,12a-Tetrahydro-2-alpha-isopropenyl-8,9-dimethoxy(1)benzopyrano(3,4-b)furo(2,3-H)(1)benzopyran-6(6AH)-one",83-79-4,Cat 2,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/06-imcg-0621e.html
+KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3E542959-8E3C-43A5-8602-B781146E96B1","JP_CHRIP:
+It was classified as Category 2 from description that it stimulated rabbit skin seriously (DFGOT (vol.19, 2003)).
+
+NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [The Pesticides Manual - CDS Tomlin]
+Eye Irritation
+R PHRASE: R 36 [The Pesticides Manual, CDS Tomlin)",,"JP_CHRIP, KR_NCIS, NZ_CCID",3,COc1cc2OC[C@H]3Oc4c5C[C@@H](Oc5ccc4C(=O)[C@H]3c2cc1OC)C(=C)C,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J108.000H,J-GLOBAL,C=C(C)[C@H]1Cc2c(ccc3c2O[C@@H]2COc4cc(OC)c(OC)cc4[C@@H]2C3=O)O1,Train,368,1,testing
+"EU_REACH:
+3,6-bis(4-methylphenyl)-1H,2H,4H,5H-pyrrolo[3,4-c]pyrrole-1,4-dione",,84632-66-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17046/7/4/2/?documentUUID=bca4fda5-5c79-47a9-8a48-69a632377f1e,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC1=CC=C(C=C1)C2=C3C(=C(N2)O)C(=NC3=O)C4=CC=C(C=C4)C,https://pubchem.ncbi.nlm.nih.gov/compound/135565865,PubChem,Cc1ccc(C2=NC(=O)c3c(-c4ccc(C)cc4)[nH]c(O)c32)cc1,Train,369,2,testing
+"EU_REACH:
+3,6-bis({[1,1'-biphenyl]-4-yl})-1H,2H,4H,5H-pyrrolo[3,4-c]pyrrole-1,4-dione",,88949-33-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7888/7/4/2/?documentUUID=c6528a2f-4bd2-4821-8809-91966c585a95,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C(C=C1)C2=CC=C(C=C2)C3=C4C(=C(N3)O)C(=NC4=O)C5=CC=C(C=C5)C6=CC=CC=C6,https://pubchem.ncbi.nlm.nih.gov/compound/135401970,PubChem,O=C1N=C(c2ccc(-c3ccccc3)cc2)c2c(O)[nH]c(-c3ccc(-c4ccccc4)cc3)c21,Train,369,2,testing
+"EU_REACH:
+2,3,3a,4,7,7a-hexahydro-1H-isoindole-1,3-dione",,85-40-5,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/1194/7/4/2/?documentUUID=e6a19792-1bd7-488f-a03a-87d77bf19551,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1C=CCC2C1C(=O)NC2=O,https://pubchem.ncbi.nlm.nih.gov/compound/6808,PubChem,O=C1NC(=O)C2CC=CCC12,Train,370,2,testing
+"JP_CHRIP:
+Tetrahydrophthalic anhydride","JP_CHRIP:
+3a,4,7,7a-Tetrahydroisobenzofuran-1,3-dione
+1,2,3,6-Tetrahydrophthalic anhydride
+1,3-Isobenzofurandione, 3a,4,7,7a-tetrahydro-
+4-Cyclohexene-1,2-dicarboxylic anhydride",85-43-8,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0091e.html,"JP_CHRIP:
+It is described that acid anhydrides are hydrated to acids and cause irritation, reddening, corneal damage, caustic dermatitis, and burns (CICAD 75 (2009), and that this substance is a corrosive irritant to the skin (HSDB (Access on May 2016)). However, the former information (CICAD) is limited to sweating skin, and other organizations have not determined this substance to be skin corrosive (GESTIS (Access on May 2016), ICSC (2001)). Therefore, the substance was classified in Category 2.
+Besides, results of ""not irritating"" in a semi-occlusive test (OECD TG 404) for 4 hours using rabbits were reported (ECHA (Access on August 2016)). However, this information was not adopted as the evidence of classification because this information was not from the listed information sources available for the GHS classification guidance of the Japanese government. The classification was changed along with the revision of information sources. Information source used in the previous classification was not available.",Provided,JP_CHRIP,1,O=C1OC(=O)C2CC=CCC12,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.015D,J-GLOBAL,O=C1OC(=O)C2CC=CCC12,Train,370,2,testing
+"JP_CHRIP:
+Chlorinated paraffin (C=14-17)",,85535-85-9,NC,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-0016.html,"JP_CHRIP:
+【分類根拠】
+（１）、（２）より、区分に該当しない（国連分類基準の区分3）。
+
+【根拠データ】
+（１）本物質（塩素含有率：40％）について、ウサギ（n=6）を用いた皮膚刺激性試験（OECD TG 404、閉塞、4時間適用、14日観察）において、皮膚の乾燥・硬化と皮膚外層の剥離が72時間後及び6～8日後に、痂皮鱗片化が6～10日後にみられた（適用24/48/72h後の紅斑・痂皮スコアの平均：1.5、浮腫スコアの平均：0.6）との報告がある（AICIS IMAP (2015)、REACH登録情報 (Accessed May 2021)）。
+（２）本物質（塩素含有率：52％）について、ウサギ（n=6）を用いた皮膚刺激性試験（OECD TG 404、閉塞、4時間適用、14日観察）において、適用6～10日後に痂皮鱗片化がみられた（適用24/48/72h後の紅斑・痂皮スコアの平均：1.3、浮腫スコアの平均：0.3）との報告がある（AICIS IMAP (2015)、REACH登録情報 (Accessed May 2021)）。",Provided,JP_CHRIP,1,CC(CC(CC(CCCC(CC(CC(C)Cl)Cl)Cl)Cl)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/121232961,PubChem,CC(Cl)CC(Cl)CC(Cl)CCCC(Cl)CC(Cl)CC(C)Cl,Train,371,1,testing
+"KR_NCIS:
+N-Methyl-2,4-cyclopentadiene-1-ethanamine",,857023-53-1,Cat 1,"KR_NCIS: https://ncis.nier.go.kr/en/main.do, button ""Hazardous chemical substances""",,,KR_NCIS,1,CNCCC1C=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/12109886,PubChem,CNCCC1C=CC=C1,Train,372,1,testing
+"EU_REACH:
+(3S)-oxolan-3-ol",,86087-23-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11545/7/4/2/?documentUUID=1d0a0e08-9253-4df1-af13-4f6d9bb91a7f,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1COC[C@H]1O,https://pubchem.ncbi.nlm.nih.gov/compound/2733227,PubChem,O[C@H]1CCOC1,Test,373,1,testing
+"EU_REACH:
+ethyl {[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]amino}acetate",,872728-83-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16526/7/4/2/?documentUUID=291fcd61-3684-449b-b335-4b4b7a36c007,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCOC(=O)CNC1=CC=C(C=C1)C2=NOC(=O)N2,https://pubchem.ncbi.nlm.nih.gov/compound/135741406,PubChem,CCOC(=O)CNc1ccc(-c2noc(=O)[nH]2)cc1,Train,374,1,testing
+"NZ_CCID:
+3,3,5-Trimethylcyclohexanone",,873-94-9,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/30ED5C6F-61B0-43B6-8B3D-9073C62B6B72,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,CC1CC(=O)CC(C1)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/13398,PubChem,CC1CC(=O)CC(C)(C)C1,Train,375,1,testing
+"EU_REACH:
+N-[ethenyl(N-ethylacetamido)methylsilyl]-N-ethylacetamide",,87855-59-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7533/7/4/2/?documentUUID=9d6a6151-c7cb-4b18-972b-bba8707f140b,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(C(=O)C)[Si](C)(C=C)N(CC)C(=O)C,https://pubchem.ncbi.nlm.nih.gov/compound/14440330,PubChem,C=C[Si](C)(N(CC)C(C)=O)N(CC)C(C)=O,Train,376,1,testing
+"NZ_CCID:
+Chloranilic acid",,87-88-7,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CFD1FB04-6F20-4636-A21B-A0F06F734E6A,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]
+Eye Irritation
+R PHRASE: R 36 [Company Data]",,NZ_CCID,1,C1(=C(C(=O)C(=C(C1=O)Cl)O)Cl)O,https://pubchem.ncbi.nlm.nih.gov/compound/66604,PubChem,O=C1C(O)=C(Cl)C(=O)C(O)=C1Cl,Train,377,1,testing
+"EU_REACH:
+1-{3-[(3-{2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecan-1-yl}propyl)disulfanyl]propyl}-2,8,9-trioxa-5-aza-1-silabicyclo[3.3.3]undecane",,883794-93-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11811/7/4/2/?documentUUID=09f79253-8a00-4d91-ada8-94db36a83154,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CO[Si]2(OCCN1CCO2)CCCSSCCC[Si]34OCCN(CCO3)CCO4,https://pubchem.ncbi.nlm.nih.gov/compound/4276941,PubChem,C(CSSCCC[Si]12OCCN(CCO1)CCO2)C[Si]12OCCN(CCO1)CCO2,Train,378,1,testing
+"JP_CHRIP:
+1, 2, 4, 5-Benzenetetracarboxylic acid anhydride","JP_CHRIP:
+1, 2, 4, 5-benzenetetracarboxylic acid anhydride
+1,2,4,5-Benzenetetracarboxylic 1,2:4,5-dianhydride
+1,2,4,5-Benzenetetracarboxylic anhydride
+1H,3H-Benzo(1,2-c;4,5-c')difuran-1,3,5,7-tetrone
+benzene-1,2:4,5-tetracarboxylic dianhydride
+PMDA
+Pyromellitic dianhydride",89-32-7,Cat 2,JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2001.html,"JP_CHRIP:
+【分類根拠】
+（１）より、区分2とした。
+
+【根拠データ】
+（１）本物質は皮膚に刺激性を示す（PubChem (Accessed May 2021)）。
+
+【参考データ等】
+（２）In vitro 皮膚腐食性試験（OECD TG 431相当、GLP）において、ばく露4時間及び24時間後の細胞生存率はそれぞれ108.1％及び96.7％であったとの報告がある（REACH登録情報 (Accessed May 2021)）。",,JP_CHRIP,1,O=c1oc(=O)c2cc3c(cc12)c(=O)oc3=O,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.301J,J-GLOBAL,O=c1oc(=O)c2cc3c(=O)oc(=O)c3cc12,Train,379,1,testing
+"EU_REACH:
+6'-(dibutylamino)-3'-methyl-2'-(phenylamino)-3H-spiro[2-benzofuran-1,9'-xanthen]-3-one",,89331-94-2,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15299/7/4/2/?documentUUID=5d8f544e-960a-40ff-bcd8-7ed7b0a82fd6,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCCN(CCCC)C1=CC2=C(C=C1)C3(C4=CC=CC=C4C(=O)O3)C5=C(O2)C=C(C(=C5)NC6=CC=CC=C6)C,https://pubchem.ncbi.nlm.nih.gov/compound/3534526,PubChem,CCCCN(CCCC)c1ccc2c(c1)Oc1cc(C)c(Nc3ccccc3)cc1C21OC(=O)c2ccccc21,Train,380,1,testing
+"EU_CLP:
+2-(2,4-dichlorophenyl)-2-(2-propenyl)oxirane",,89544-48-9,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C=CCC1(CO1)C2=C(C=C(C=C2)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/5463810,PubChem,C=CCC1(c2ccc(Cl)cc2Cl)CO1,Test,381,1,testing
+"EU_REACH:
+2-[2-(oxolan-2-yl)propan-2-yl]oxolane",,89686-69-1,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8620/7/4/2/?documentUUID=e6d005e8-332f-45f6-aa97-d37dfec19a3a,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)(C1CCCO1)C2CCCO2,https://pubchem.ncbi.nlm.nih.gov/compound/551484,PubChem,CC(C)(C1CCCO1)C1CCCO1,Train,382,1,testing
+"EU_REACH:
+2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine",,90213-66-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/23997/7/4/2/?documentUUID=d5629ab6-754b-43cb-a869-2ac87cffaa23,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CNC2=C1C(=NC(=N2)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/14116871,PubChem,Clc1nc(Cl)c2cc[nH]c2n1,Train,383,1,testing
+"AU_HCIS:
+Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-(2-aminomethylethyl)-.omega.-(2-aminomethylethoxy)-
+
+NZ_CCID:
+Diaminopolypropylene glycol","NZ_CCID:
+Ablebond 342-1 Hardener, D 2000, D 230, DA 500, DA 500 (polyoxyalkylene), Etherdiamine MG 420, Jeffamine 2000 Jeffamine 2000, Jeffamine 400, Jeffamine D 1000, Jeffamine D 2000, Jeffamine D 230, Jeffamine D 3000, Jeffamine D 400, Jeffamine D 4000, Jeffamine D 600, Jeffamine D 800, Jeffamine TA 345, MG 420, PC Amine DA 2000, POPDA, Poly(oxy(methyl-1,2-ethanediyl)), alpha-(2-aminomethylethyl)-omega-(2-aminomethylethoxy)-, Poly(oxypropylene)diamine, Poly[oxy(methyl-1,2-ethanediyl)], .alpha.-(2-aminomethylethyl)-.omega.-(2-aminomethylethoxy)-, Polypropylene glycol bis(2-aminopropyl) ether, Polypropylene glycol bis(aminopropyl) ether, TS 64, XNH 3351, alpha,omega-Diaminopolypropylene glycol, alpha-(2-Aminomethylethyl)-omega-(2-aminomethylethoxy)poly(oxy(methyl-1,2-ethanediyl))",9046-10-0,Cat 1,"AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5188
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C860790B-DF74-4EC5-817A-0011FBDF6625","NZ_CCID:
+Skin Irritation
+REMARK: Classification based on pH level. pH =11.7 (5% solution)[ MSDSs from Google]
+Eye Irritation
+REMARK: Classification based on pH level. pH =11.7 (5% solution)[ MSDSs from Google]",,"AU_HCIS, NZ_CCID",2,C1[C@@H]([C@H](CN1)O)O,https://pubchem.ncbi.nlm.nih.gov/compound/146198,PubChem,O[C@H]1CNC[C@@H]1O,Train,384,1,testing
+"EU_REACH:
+4-[(4,6-bis{[3-(diethylamino)propyl]amino}-1,3,5-triazin-2-yl)amino]-N-[2-(4,5,6,7-tetrachloro-1,3-dioxo-2,3-dihydro-1H-inden-2-yl)quinolin-8-yl]benzenesulfonamide",,909782-35-0,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6459/7/4/2/?documentUUID=126a468e-4b27-499e-bd29-619bb406c2d3,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCN(CC)CCCNC1=NC(=NC(=N1)NC2=CC=C(C=C2)S(=O)(=O)NC3=CC=CC4=C3N=C(C=C4)C5C(=O)C6=C(C5=O)C(=C(C(=C6Cl)Cl)Cl)Cl)NCCCN(CC)CC,https://pubchem.ncbi.nlm.nih.gov/compound/102171486,PubChem,CCN(CC)CCCNc1nc(NCCCN(CC)CC)nc(Nc2ccc(S(=O)(=O)Nc3cccc4ccc(C5C(=O)c6c(Cl)c(Cl)c(Cl)c(Cl)c6C5=O)nc34)cc2)n1,Train,385,1,testing
+"EU_REACH:
+(3S)-3-[4-(2-chloro-5-iodobenzoyl)phenoxy]oxolane",,915095-87-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5737/7/4/2/?documentUUID=5eb9db26-5b55-44da-9df0-6b3fe34f9c4a,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1COC[C@H]1OC2=CC=C(C=C2)C(=O)C3=C(C=CC(=C3)I)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/59423635,PubChem,O=C(c1ccc(O[C@H]2CCOC2)cc1)c1cc(I)ccc1Cl,Train,386,1,testing
+"EU_REACH:
+[(3S,4R,4aR,6S,6aS,12R,12aS,12bS)-3-(cyclopropanecarbonyloxy)-6,12-dihydroxy-4,6a,12btrimethyl-11-oxo-9-(pyridin-3-yl)-1,2,3,4,4a,5,6,6a,12a,12b-decahydro-11H,12Hbenzo[f]pyrano[4,3-b]chromen-4-yl]methylcyclopropanecarboxylate",,915972-17-7,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/21194/7/4/2/?documentUUID=b1318d1c-2e94-4f82-90d0-54a822ec62ff,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C[C@]12CC[C@@H]([C@@]([C@@H]1C[C@@H]([C@@]3([C@@H]2[C@H](C4=C(O3)C=C(OC4=O)C5=CN=CC=C5)O)C)O)(C)COC(=O)C6CC6)OC(=O)C7CC7,https://pubchem.ncbi.nlm.nih.gov/compound/54589430,PubChem,C[C@]1(COC(=O)C2CC2)[C@@H]2C[C@H](O)[C@@]3(C)Oc4cc(-c5cccnc5)oc(=O)c4[C@H](O)[C@@H]3[C@@]2(C)CC[C@@H]1OC(=O)C1CC1,Train,387,1,testing
+"NZ_CCID:
+1,1,1,3,3,3-Hexafluoro-2-propanol",,920-66-1,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/98B40B7B-AEA3-4A73-B306-AB5A83189482,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,C(C(F)(F)F)(C(F)(F)F)O,https://pubchem.ncbi.nlm.nih.gov/compound/13529,PubChem,OC(C(F)(F)F)C(F)(F)F,Train,388,1,testing
+"EU_CLP:
+1,2-dimethyl-3-(1-methylethenyl)cyclopentyl acetate",,94346-09-5,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,CC1C(CCC1(C)OC(=O)C)C(=C)C,https://pubchem.ncbi.nlm.nih.gov/compound/21156163,PubChem,C=C(C)C1CCC(C)(OC(C)=O)C1C,Test,389,1,testing
+"EU_CLP:
+bis(piperidinothiocarbonyl) disulphide",,94-37-1,Cat 2,"EU_CLP: https://echa.europa.eu/information-on-chemicals/annex-vi-to-clp, Annex VI to CLP_ATP18",,,EU_CLP,1,C1CCN(CC1)C(=S)SSC(=S)N2CCCCC2,https://pubchem.ncbi.nlm.nih.gov/compound/7188,PubChem,S=C(SSC(=S)N1CCCCC1)N1CCCCC1,Test,390,1,testing
+"JP_CHRIP:
+[Methyl(oxo){1-[6-(trifluoromethyl)-3-pyridyl]ethyl}-lambda(6)-sulfanylidene]carbamonitrile; Sulfoxaflor",,946578-00-3,NC,JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-0001e.html,"JP_CHRIP:
+[Rationale for the Classification]
+It was classified as ""Not classified"" from (1) - (3).
+
+[Evidence Data]
+(1) In a skin irritation test with rabbits according to OECD TG 404, the mean score at 24/48/72 hours was all < 2.3, and all signs disappeared after 72 hours (EU CLP CLH (2013), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2014), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2016)).
+(2) This substance was not irritating to the skin and eye of rabbits (JMPR (2011), HSDB (Access on April 2020)).
+(3) This substance caused only mild skin irritation in rabbits with minimal erythema and edema seen at 1 but not at 24 hours post-application (ACGIH (7th, 2019)).",Provided,JP_CHRIP,1,CC(c1ccc(nc1)C(F)(F)F)[S+](=NC#N)(C)[O-],https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.920.636H,J-GLOBAL,CC(c1ccc(C(F)(F)F)nc1)[S+](C)([O-])=NC#N,Train,391,1,testing
+"EU_REACH:
+(3,3-dimethylbutan-2-yl)({6-[(3,3-dimethylbutan-2-yl)amino]hexyl})amine",,957787-76-7,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12306/7/4/2/?documentUUID=e0332a74-9195-4b54-b384-499cb6b58d3a,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C(C)(C)C)NCCCCCCNC(C)C(C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/87165727,PubChem,CC(NCCCCCCNC(C)C(C)(C)C)C(C)(C)C,Train,392,1,testing
+"EU_REACH:
+1-[(1R,3S,6S)-2,2,3,6-tetramethylcyclohexyl]hexan-3-ol",,95851-08-4,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31884/7/4/2/?documentUUID=b8a6a03e-233d-4832-8b62-96c3f5d405b6,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCCC(CCC1C(CCC(C1(C)C)C)C)O,https://pubchem.ncbi.nlm.nih.gov/compound/22326187,PubChem,CCCC(O)CCC1C(C)CCC(C)C1(C)C,Train,393,1,testing
+"NZ_CCID:
+1-Methylpyrrole",,96-54-8,Cat 2,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/556D6161-41A9-4547-84FE-4DE7C1711CB7,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 38 [Company Data]",,NZ_CCID,1,CN1C=CC=C1,https://pubchem.ncbi.nlm.nih.gov/compound/7304,PubChem,Cn1cccc1,Train,394,1,testing
+"EU_REACH:
+1-(2,5-dioxoimidazolidin-4-yl)urea",,97-59-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13641/7/4/2/?documentUUID=dfbe1428-6ee4-4e73-bbdf-57019e1e6194,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1(C(=O)NC(=O)N1)NC(=O)N,https://pubchem.ncbi.nlm.nih.gov/compound/204,PubChem,NC(=O)NC1NC(=O)NC1=O,Train,395,1,testing
+"JP_CHRIP:
+Triethylborane
+
+NZ_CCID:
+Borane, triethyl-","NZ_CCID:
+Triethylborane, Triethylboron",97-94-9,Cat 1,"JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0199e.html
+NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DA2A3A18-B3F5-4666-AD2A-6C944F6126B4","JP_CHRIP:
+The substance was classified as Category 1 based on the documents that the substance caused strong irritation to human skin, eye and respiratory system (HSDB (2010)) and the substance was classified as ""C; R34 (Skin Corr. 1B)"" as trialkyboranes in the EU classification (EC-JRC (ESIS) (Access on Dec. 2010)).
+
+NZ_CCID:
+Skin Irritation
+R-PHRASE: R 34 Causes burns. [N-CLASS]
+Eye Irritation
+R-PHRASE: R 34 Causes burns. [N-CLASS]",,"JP_CHRIP, NZ_CCID",2,CCB(CC)CC,https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J55.478B,J-GLOBAL,CCB(CC)CC,Train,396,1,testing
+"EU_REACH:
+(2R)-6-fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-1-benzopyran; (2R)-6-fluoro-2-[(2S)-oxiran-2-yl]-3,4-dihydro-2H-1-benzopyran; (2S)-6-fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-1-benzopyran; (2S)-6-fluoro-2-[(2S)-oxiran-2-yl]-3,4-dihydro-2H-1-benzopyran",,99199-90-3,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7989/7/4/2/?documentUUID=c0d62c61-66f0-4edb-9563-92c0f06152b6,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1CC2=C(C=CC(=C2)F)OC1C3CO3,https://pubchem.ncbi.nlm.nih.gov/compound/11658439,PubChem,Fc1ccc2c(c1)CCC(C1CO1)O2,Train,397,1,testing
+"EU_REACH:
+1,5,2,4-dioxadithiane 2,2,4,4-tetraoxide",,99591-74-9,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7762/7/4/2/?documentUUID=e8145276-df84-424d-8ad0-bc3ae18b5e65,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1OS(=O)(=O)CS(=O)(=O)O1,https://pubchem.ncbi.nlm.nih.gov/compound/11600810,PubChem,O=S1(=O)CS(=O)(=O)OCO1,Train,398,1,testing
+"EU_REACH:
+dimethyl(propan-2-yl)amine",,996-35-0,Cat 1,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13880/7/4/2/?documentUUID=7425a16d-9690-43c5-990d-bb20be72b921,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CC(C)N(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/70452,PubChem,CC(C)N(C)C,Train,399,1,testing
+"NZ_CCID:
+Diethylaminotrimethylsilane","NZ_CCID:
+N,N-diethyltrimethylsilylamine",996-50-9,Cat 1,NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FF37B5D2-C349-4EE7-B15B-2363FF81881A,"NZ_CCID:
+Skin Irritation
+R PHRASE: R 34 [Company Data]
+Eye Irritation
+R PHRASE: R 34 [Company Data]",,NZ_CCID,1,CCN(CC)[Si](C)(C)C,https://pubchem.ncbi.nlm.nih.gov/compound/70454,PubChem,CCN(CC)[Si](C)(C)C,Train,400,1,testing
+"EU_REACH:
+1,2,3-trichloro-12,24-dihydro-5H-naphtho[2,3-h]naphtho[2'',3'':6',7']indolo[2',3':6,7]anthra[2,1,9-mna]acridine-5,10,13,18,25-pentone",,99688-45-6,NC,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24668/7/4/2/?documentUUID=e9988da8-b9fa-423f-a563-dcb52766b31c,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C4=C(C=C3)C5=CC6=C(C=C5N4)C(=O)C7=C8C6=C(C(=C9C8=C(C=C7)C1=C(N9Cl)C2=C(C=C1)C(=O)C1=CC=CC=C1C2=O)Cl)Cl,https://pubchem.ncbi.nlm.nih.gov/compound/44147486,PubChem,O=C1c2ccccc2C(=O)c2c1ccc1c2[nH]c2cc3c(=O)c4ccc5c6ccc7c(c6n(Cl)c6c(Cl)c(Cl)c(c3cc21)c4c56)C(=O)c1ccccc1C7=O,Train,401,1,testing
+"EU_REACH:
+triethoxysilane",,998-30-1,Cat 2,EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5339/7/4/2/?documentUUID=13e58419-4847-45ea-9017-a744753cbac5,"EU_REACH:
+Experimental study (OECD TG 404, GLP)",Provided,EU_REACH,1,CCO[Si](OCC)OCC,https://pubchem.ncbi.nlm.nih.gov/compound/6327710,PubChem,CCO[Si](OCC)OCC,Train,402,1,testing