| rank,benchmark_id,pmid,perturbation,tissue,n_targets,direction_matches,direction_match_rate,main_conclusion_coverage,core_conclusion_covered,direction_mismatches,target_genes,paper_title,core_size_gib,n_control_cells,n_treated_cells |
| 1,38937474_01,38937474,osimertinib,Lung,34,32,0.9411764705882352,高,AT1样分化、黏液/浆液谱系丢失、EMT/RHO-细胞骨架重塑及细胞周期抑制,CENPF:DOWN->UP; SPDL1:DOWN->NS,"ADAM12,AGER,AQP4,BPIFB1,BPIFB2,CDH2,CENPF,CLIC5,CNN1,CYP4B1,DIAPH2,LMNA,LMNB1,LMNB2,MATN2,MUC5B,MYH14,MYH9,MYL9,MYLK,PIGR,RHOB,RHOBTB3,RND3,SCGB3A1,SERPINE1,SFTPD,SNAI2,SPDL1,SPOCK1,TAGLN,TNNC1,TRIO,TWIST1",Farnesyltransferase inhibition overcomes oncogene-addicted non-small cell lung cancer adaptive resistance to targeted therapies,0.1452786941081285,3432,4728 |
| 2,38895265_01,38895265,Paclitaxel,Breast,18,18,1.0,高,紫杉醇诱导ISR/干扰素样反应、免疫调节与炎症趋化因子程序,,"ATF3,B2M,CD47,CD55,CD59,CD63,CXCL1,CXCL8,DDIT3,HLA-B,HLA-C,IRF7,IRF9,JUN,JUNB,MAFF,PLSCR1,SP100",TNBC response to paclitaxel phenocopies interferon response which reveals cell cycle-associated resistance mechanisms,0.4852075045928359,1830,1289 |
| 3,34591417_01,34591417,vemurafenib,Skin,14,14,1.0,高,BRAF抑制后的黑色素谱系丢失、细胞周期/p53与AXL耐药轨迹,,"AXL,CD74,CDK1,CDKN1A,CENPU,ERBB3,HLA-DRA,HMGN2,MDM2,RAMP1,RANBP1,SOX10,STMN1,UBE2S",Single-cell trajectories of melanoma cell resistance to targeted treatment,0.5450525600463152,6386,4143 |
| 4,40766395_01,40766395,Brefeldin A,Liver,14,14,1.0,高,Brefeldin A诱导UPR，并伴随凋亡、自噬和ER应激异质性,,"ARF4,ATF4,DDIT3,GOLGA3,GTF2F1,HSPA5,HYOU1,INHBE,LMF2,PDIA4,SLC38A10,SQSTM1,SYVN1,ZNF598",Decoding Cellular Stress States for Toxicology Using Single-Cell Transcriptomics,1.4039169680327177,6926,2756 |
| 5,37086265_01,37086265,etoposide,Lung,18,16,0.8888888888888888,高,依托泊苷诱导的晚期衰老：停滞/存活/SASP及核纤层改变,JMJD1C:DOWN->NS; MAGI2:DOWN->UP,"BCL2L2,CCND1,CDKN1A,CDKN2A,DPP4,GADD45A,GDF15,IL6,JMJD1C,LBR,LMNB1,MAGI2,MDM2,PINK1,SERF2,SRP14,TCF12,TSPO",Single-cell transcriptomic analysis uncovers diverse and dynamic senescent cell populations,2.565313506871462,10981,8925 |
| 6,33712615_01,33712615,erlotinib,Lung,19,15,0.7894736842105263,高,EGFR-TKI耐受状态、EMT/转运标志及胆固醇稳态抑制,CDKN2B:NS->UP; FDFT1:DOWN->NS; FDPS:DOWN->NS; RDH11:DOWN->NS,"CDKN2B,CITED2,FASN,FDFT1,FDPS,GATA6,HSD17B7,IDI1,IGFBP3,IGFBP5,INSIG1,KRT17,LDLR,PCSK9,PDLIM1,RDH11,SERPINE1,SLC7A5,SQLE",Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer,0.0900852847844362,1108,1041 |
| 7,32846134_01,32846134,5-fluorouracil,Colon,9,9,1.0,高,5-FU后p53检查点、细胞周期抑制、自噬/核糖体变化与细胞命运异质性,,"CCNB1,CDC20,CDKN1A,CDKN3,GADD45A,MAP1LC3B,MDM2,RPL10A,RPL27A",Single-Cell Transcriptome Analysis of Colon Cancer Cell Response to 5-Fluorouracil-Induced DNA Damage,0.0848879441618919,1638,1489 |
| 8,37732484_01,37732484,paclitaxel,Aorta,11,10,0.9090909090909092,高,紫杉醇下微管/细胞骨架和应激反应，以及内皮适应状态,HYAL2:DOWN->NS,"ADAMTS1,ATF4,HYAL2,IGFBP5,MAP2,MSMO1,RGS5,TUBA1A,TUBA1B,TUBB,TUBB2A",Single-Cell RNA Sequencing Reveals That Adaptation of Human Aortic Endothelial Cells to Antiproliferative Therapies Is Modulated by Flow-Induced Shear Stress,0.4291655961424112,8678,555 |
| 9,36318267_01,36318267,estradiol,Breast,8,8,1.0,高,雌激素诱导的FOXM1-细胞周期分支，覆盖论文的核心异质响应轴,,"AURKA,CCNB1,CENPF,FOXM1,H2AZ1,HMGB2,MKI67,PTTG1",Estrogen regulates divergent transcriptional and epigenetic cell states in breast cancer,0.1619712077081203,2519,2774 |
| 10,36553506_01,36553506,panobinostat,Brain,12,10,0.8333333333333334,高,Panobinostat诱导衰老/增殖下降、神经分化及MYCN等主调控因子变化,MAZ:DOWN->NS; MYCN:DOWN->NS,"BAZ1A,BID,CENPV,CHRNA3,H1-0,HCFC1,MAZ,MYCN,RGS16,SRRM2,TP53,ZNF146",Single-Cell Sequencing Identifies Master Regulators Affected by Panobinostat in Neuroblastoma Cells,0.229586686939001,1213,873 |
| 11,35410383_01,35410383,Fluorouracil,Breast,6,6,1.0,高,TNBC中H3K27me3相关5-FU耐受细胞状态及其标志程序,,"FOSL1,FOXQ1,KRT14,NNMT,NR2F2,TAGLN",H3K27me3 conditions chemotolerance in triple-negative breast cancer,4.653750481083989,4398,38687 |
| 12,41871169_01,41871169,panobinostat,B lymphoblast,6,6,1.0,高,HDAC抑制后的EBV abortive/refractory状态及STAT-CD137/CD137L信号,,"BCL2,CCR7,STAT1,STAT3,TNFRSF9,TNFSF9",Single-cell profiling of HDAC inhibitor-induced EBV lytic heterogeneity defines abortive and refractory states in B lymphoblasts,1.01159571390599,10130,5472 |
| 13,38652658_01,38652658,ispinesib,Brain,9,8,0.8888888888888888,中高,Ispinesib耐药克隆及可联合靶向的WNK3/RIOK1/MYB/CTSF等脆弱点,RIOK1:UP->NS,"ADA,CERK,CHKA,CTSF,HDAC4,MAP3K11,MYB,RIOK1,WNK3",Multiplexed single-cell lineage tracing of mitotic kinesin inhibitor resistance in glioblastoma,4.582534008659422,132185,132614 |
| 14,36382181_01,36382181,enzalutamide,Prostate,9,7,0.7777777777777778,高,Enzalutamide诱导神经内分泌分化及AR/前列腺谱系动态重编程,ASCL1:NS->UP; SYP:NS->DOWN,"AR,ASCL1,ENO2,FKBP5,KLK2,KLK3,NCAM1,STEAP2,SYP",Reprogramming landscape highlighted by dynamic transcriptomes in therapy-induced neuroendocrine differentiation,3.4254743112251163,8574,25247 |
| 15,32094658_01,32094658,latrunculin A,Pancreas,4,4,1.0,高,细胞骨架扰动驱动胰腺内分泌分化：NEUROG3/NKX2-2/NEUROD1与NKX6-1,,"NEUROD1,NEUROG3,NKX2-2,NKX6-1",Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells,0.1433440363034606,686,1042 |
| 16,38272949_02,38272949,GW3965,Brain,4,4,1.0,高,LXR激动剂诱导微胶质细胞脂质代谢及状态异质性,,"ABCA1,ABCG1,ACSL1,APOE",Transcriptional characterization of iPSC‑derived microglia as a model for therapeutic development in neurodegeneration,2.1371660847216845,7674,15867 |
| 17,38589664_01,38589664,cisplatin,Stomach,3,3,1.0,高,NER缺陷胃癌的cisplatin敏感性，以及POLR2L和SAT1/SLC3A2所代表的NER-铁死亡机制,,"POLR2L,SAT1,SLC3A2",Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting,0.5032572047784925,4135,6183 |
| 18,39803533_01,39803533,TCDD,Skin,3,3,1.0,高,TCDD后线粒体网络-氧化还原调控及干性状态轴,,"MT-ND1,MT-ND4,MT-ND6",Quantitative analyses of single mitochondrial structure-function heterogeneity uncovers stemness specification by redox-tuned small-mitochondrial-networks,1.173319272696972,5774,10692 |
| 19,40166195_01,40166195,doxorubicin,Breast,3,3,1.0,高,多柔比星后TNBC克隆特异转录状态及稀有恢复克隆标志,,"LDLRAD4,PCSK6,SAMD5",Lineage Tracing Reveals Clone-Specific Responses to Doxorubicin in Triple-Negative Breast Cancer,6.062345305457711,8284,23710 |
| 20,34857732_01,34857732,GSK126,Prostate,8,5,0.625,高,EZH2抑制逆转前列腺癌进展中的G2/M和AR分化程序,CDK1:DOWN->NS; TMPRSS2:UP->NS; UBE2C:DOWN->NS,"ABCC4,CDK1,IL13,IL4,KLK2,KLK3,TMPRSS2,UBE2C",Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression,0.5854820003733039,7700,5436 |
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