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Datasets:
mindflow-cn
/
scDrugPerturb-Bench

Tasks:
Feature Extraction
Languages:
English
Chinese
Size:
100K<n<1M
Tags:
single-cell
transcriptomics
perturbation
drug-response
mechanism-aware
paper-grounded
License:
Dataset card Files
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 Community
mindflow-cn commited on
Commit
965ba61
·
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1 Parent(s): bcf0257

Add 33712615_01 test_case.json

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Files changed (1) hide show
  1. data/33712615_01/test_case.json +162 -0
data/33712615_01/test_case.json ADDED
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+ {
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+ "benchmark_id": "33712615_01",
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+ "sample_system": "",
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+ "tissue": "Lung",
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+ "source_type": "cell_line",
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+ "perturbation_type": "drug",
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+ "perturbation_name": "erlotinib",
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+ "default_cell_subset": "",
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+ "description": "PC9 NSCLC cell line treated with erlotinib EGFR TKI.",
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+ "smiles": "COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC",
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+ "test_cases": [
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+ {
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+ "test_id": "33712615_01_01",
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+ "target_genes": [
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+ "SERPINE1"
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+ ],
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+ "perturb_var": "time",
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+ "control": "C",
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+ "dose_groups": [
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+ "2.0 uM"
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+ ],
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+ "time_groups": [
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+ "1 day",
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+ "2 day",
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+ "4 day",
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+ "9 day",
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+ "11 day"
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+ ],
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+ "relation": "UP",
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+ "cell_type": "PC9 NSCLC cell line"
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+ },
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+ {
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+ "test_id": "33712615_01_02",
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+ "target_genes": [
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+ "KRT17"
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+ ],
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+ "perturb_var": "time",
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+ "control": "C",
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+ "dose_groups": [
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+ "2.0 uM"
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+ ],
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+ "time_groups": [
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+ "1 day",
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+ "2 day",
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+ "4 day",
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+ "9 day",
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+ "11 day"
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+ ],
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+ "relation": "UP",
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+ "cell_type": "PC9 NSCLC cell line"
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+ },
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+ {
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+ "test_id": "33712615_01_03",
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+ "target_genes": [
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+ "FASN",
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+ "FDFT1",
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+ "FDPS",
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+ "HSD17B7",
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+ "IDI1",
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+ "INSIG1",
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+ "LDLR",
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+ "PCSK9",
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+ "RDH11",
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+ "SQLE"
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+ ],
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+ "perturb_var": "time",
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+ "control": "C",
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+ "dose_groups": [
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+ "2.0 uM"
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+ ],
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+ "time_groups": [
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+ "1 day",
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+ "2 day",
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+ "4 day",
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+ "9 day",
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+ "11 day"
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+ ],
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+ "relation": "DOWN",
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+ "cell_type": "PC9 NSCLC cell line"
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+ },
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+ {
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+ "test_id": "33712615_01_04",
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+ "target_genes": [
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+ "GATA6",
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+ "CITED2"
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+ ],
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+ "perturb_var": "time",
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+ "control": "C",
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+ "dose_groups": [
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+ "2.0 uM"
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+ ],
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+ "time_groups": [
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+ "1 day",
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+ "2 day",
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+ "4 day",
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+ "9 day",
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+ "11 day"
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+ ],
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+ "relation": "UP",
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+ "cell_type": "PC9 NSCLC cell line"
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+ },
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+ {
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+ "test_id": "33712615_01_05",
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+ "target_genes": [
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+ "IGFBP3",
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+ "IGFBP5",
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+ "SERPINE1"
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+ ],
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+ "perturb_var": "time",
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+ "control": "C",
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+ "dose_groups": [
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+ "2.0 uM"
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+ ],
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+ "time_groups": [
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+ "1 day",
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+ "2 day",
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+ "4 day",
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+ "9 day",
119
+ "11 day"
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+ ],
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+ "relation": "UP",
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+ "cell_type": "PC9 NSCLC cell line"
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+ },
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+ {
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+ "test_id": "33712615_01_06",
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+ "target_genes": [
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+ "PDLIM1",
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+ "SLC7A5"
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+ ],
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+ "perturb_var": "time",
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+ "control": "C",
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+ "dose_groups": [
133
+ "2.0 uM"
134
+ ],
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+ "time_groups": [
136
+ "1 day",
137
+ "2 day",
138
+ "4 day",
139
+ "9 day",
140
+ "11 day"
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+ ],
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+ "relation": "UP",
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+ "cell_type": "PC9 NSCLC cell line"
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+ },
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+ {
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+ "test_id": "33712615_01_08",
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+ "target_genes": [
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+ "CDKN2B"
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+ ],
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+ "perturb_var": "time",
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+ "control": "C",
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+ "dose_groups": [
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+ "2.0 uM"
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+ ],
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+ "time_groups": [
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+ "11 day"
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+ ],
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+ "relation": "NS",
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+ "cell_type": "PC9 NSCLC cell line"
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+ }
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+ ]
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+ }