{
  "benchmark_id": "36382181_01",
  "sample_system": "",
  "tissue": "Prostate",
  "source_type": "cell_line",
  "perturbation_type": "drug",
  "perturbation_name": "enzalutamide",
  "default_cell_subset": "",
  "description": "LNCaP prostate cancer cells treated with 5 uM enzalutamide over 4, 7, and 14 days.",
  "smiles": "CC1(C(=O)N(C(=S)N1C2=CC(=C(C=C2)C(=O)NC)F)C3=CC(=C(C=C3)C#N)C(F)(F)F)C",
  "test_cases": [
    {
      "test_id": "36382181_01_01",
      "target_genes": [
        "ENO2",
        "STEAP2"
      ],
      "perturb_var": "dose",
      "control": "C",
      "dose_groups": [
        "5.0 uM"
      ],
      "time_groups": [
        "14 day"
      ],
      "relation": "UP",
      "cell_type": "LNCaP prostate cancer cell line"
    },
    {
      "test_id": "36382181_01_02",
      "target_genes": [
        "KLK2",
        "KLK3",
        "FKBP5"
      ],
      "perturb_var": "dose",
      "control": "C",
      "dose_groups": [
        "5.0 uM"
      ],
      "time_groups": [
        "14 day"
      ],
      "relation": "DOWN",
      "cell_type": "LNCaP prostate cancer cell line"
    },
    {
      "test_id": "36382181_01_03",
      "target_genes": [
        "AR"
      ],
      "perturb_var": "dose",
      "control": "C",
      "dose_groups": [
        "5.0 uM"
      ],
      "time_groups": [
        "14 day"
      ],
      "relation": "UP",
      "cell_type": "LNCaP prostate cancer cell line"
    },
    {
      "test_id": "36382181_01_04",
      "target_genes": [
        "ENO2",
        "ENO2",
        "STEAP2"
      ],
      "perturb_var": "dose",
      "control": "C",
      "dose_groups": [
        "5.0 uM"
      ],
      "time_groups": [
        "14 day"
      ],
      "relation": "UP",
      "cell_type": "LNCaP prostate cancer cell line"
    },
    {
      "test_id": "36382181_01_07",
      "target_genes": [
        "ASCL1",
        "NCAM1",
        "SYP"
      ],
      "perturb_var": "dose",
      "control": "C",
      "dose_groups": [
        "5.0 uM"
      ],
      "time_groups": [
        "14 day"
      ],
      "relation": "NS",
      "cell_type": "LNCaP prostate cancer cell line"
    },
    {
      "test_id": "36382181_01_05",
      "target_genes": [
        "KLK2",
        "KLK3",
        "FKBP5"
      ],
      "perturb_var": "dose",
      "control": "C",
      "dose_groups": [
        "5.0 uM"
      ],
      "time_groups": [
        "14 day"
      ],
      "relation": "DOWN",
      "cell_type": "LNCaP prostate cancer cell line"
    },
    {
      "test_id": "36382181_01_06",
      "target_genes": [
        "AR"
      ],
      "perturb_var": "dose",
      "control": "C",
      "dose_groups": [
        "5.0 uM"
      ],
      "time_groups": [
        "14 day"
      ],
      "relation": "UP",
      "cell_type": "LNCaP prostate cancer cell line"
    }
  ]
}