{
  "benchmark_id": "37086265_01",
  "sample_system": "",
  "tissue": "Lung",
  "source_type": "cell_line",
  "perturbation_type": "drug",
  "perturbation_name": "etoposide",
  "default_cell_subset": "",
  "description": "WI-38 fetal lung fibroblasts treated with etoposide \u2014 late senescence program (Day 4-10).",
  "smiles": "CC1OCC2C(O1)C(C(C(O2)OC3C4COC(=O)C4C(C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O",
  "test_cases": [
    {
      "test_id": "37086265_01_01",
      "target_genes": [
        "CDKN1A",
        "CDKN2A",
        "BCL2L2",
        "IL6",
        "PINK1",
        "CCND1",
        "DPP4"
      ],
      "perturb_var": "time",
      "control": "C",
      "dose_groups": [
        "50 uM"
      ],
      "time_groups": [
        "4 day",
        "7 day",
        "10 day"
      ],
      "relation": "UP",
      "cell_type": "WI-38 fetal lung fibroblast cell line"
    },
    {
      "test_id": "37086265_01_02",
      "target_genes": [
        "LMNB1",
        "LBR"
      ],
      "perturb_var": "time",
      "control": "C",
      "dose_groups": [
        "50 uM"
      ],
      "time_groups": [
        "4 day",
        "7 day",
        "10 day"
      ],
      "relation": "DOWN",
      "cell_type": "WI-38 fetal lung fibroblast cell line"
    },
    {
      "test_id": "37086265_01_03",
      "target_genes": [],
      "perturb_var": "time",
      "control": "C",
      "dose_groups": [
        "50 uM"
      ],
      "time_groups": [
        "4 day",
        "7 day",
        "10 day"
      ],
      "relation": "UP",
      "cell_type": "WI-38 fetal lung fibroblast cell line"
    },
    {
      "test_id": "37086265_01_04",
      "target_genes": [
        "GADD45A",
        "GDF15",
        "MDM2"
      ],
      "perturb_var": "time",
      "control": "C",
      "dose_groups": [
        "50 uM"
      ],
      "time_groups": [
        "4 day",
        "7 day",
        "10 day"
      ],
      "relation": "UP",
      "cell_type": "WI-38 fetal lung fibroblast cell line"
    },
    {
      "test_id": "37086265_01_05",
      "target_genes": [
        "TCF12",
        "MAGI2",
        "JMJD1C"
      ],
      "perturb_var": "time",
      "control": "C",
      "dose_groups": [
        "50 uM"
      ],
      "time_groups": [
        "4 day",
        "7 day",
        "10 day"
      ],
      "relation": "DOWN",
      "cell_type": "WI-38 fetal lung fibroblast cell line"
    },
    {
      "test_id": "37086265_01_06",
      "target_genes": [
        "SRP14",
        "SERF2",
        "TSPO"
      ],
      "perturb_var": "time",
      "control": "C",
      "dose_groups": [
        "50 uM"
      ],
      "time_groups": [
        "4 day",
        "7 day",
        "10 day"
      ],
      "relation": "UP",
      "cell_type": "WI-38 fetal lung fibroblast cell line"
    }
  ]
}