{
  "benchmark_id": "38937474_01",
  "sample_system": "",
  "tissue": "Lung",
  "source_type": "cell_line",
  "perturbation_type": "drug",
  "perturbation_name": "osimertinib",
  "default_cell_subset": "",
  "description": "HCC4006 EGFR-mutant NSCLC cell line treated with osimertinib.",
  "smiles": "CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC",
  "test_cases": [
    {
      "test_id": "38937474_01_01",
      "target_genes": [
        "AGER",
        "AQP4",
        "CLIC5",
        "CYP4B1",
        "TNNC1",
        "SFTPD"
      ],
      "perturb_var": "dose",
      "control": "C",
      "dose_groups": [
        "1.0 uM"
      ],
      "time_groups": [
        "20 days"
      ],
      "relation": "UP",
      "cell_type": "HCC4006 EGFR-mutant NSCLC cell line"
    },
    {
      "test_id": "38937474_01_02",
      "target_genes": [
        "SERPINE1",
        "ADAM12",
        "SPOCK1",
        "MATN2",
        "TWIST1",
        "TAGLN",
        "CNN1",
        "SNAI2",
        "CDH2"
      ],
      "perturb_var": "dose",
      "control": "C",
      "dose_groups": [
        "1.0 uM"
      ],
      "time_groups": [
        "20 days"
      ],
      "relation": "UP",
      "cell_type": "HCC4006 EGFR-mutant NSCLC cell line"
    },
    {
      "test_id": "38937474_01_03",
      "target_genes": [
        "PIGR",
        "BPIFB1",
        "BPIFB2",
        "SCGB3A1",
        "MUC5B"
      ],
      "perturb_var": "dose",
      "control": "C",
      "dose_groups": [
        "1.0 uM"
      ],
      "time_groups": [
        "20 days"
      ],
      "relation": "DOWN",
      "cell_type": "HCC4006 EGFR-mutant NSCLC cell line"
    },
    {
      "test_id": "38937474_01_04",
      "target_genes": [
        "MYL9",
        "RND3",
        "RHOB",
        "RHOBTB3",
        "MYH9",
        "DIAPH2",
        "MYH14",
        "MYLK",
        "TRIO"
      ],
      "perturb_var": "dose",
      "control": "C",
      "dose_groups": [
        "1.0 uM"
      ],
      "time_groups": [
        "20 days"
      ],
      "relation": "UP",
      "cell_type": "HCC4006 EGFR-mutant NSCLC cell line"
    },
    {
      "test_id": "38937474_01_05",
      "target_genes": [
        "LMNB1",
        "LMNB2",
        "LMNA",
        "CENPF",
        "SPDL1"
      ],
      "perturb_var": "dose",
      "control": "C",
      "dose_groups": [
        "1.0 uM"
      ],
      "time_groups": [
        "20 days"
      ],
      "relation": "DOWN",
      "cell_type": "HCC4006 EGFR-mutant NSCLC cell line"
    }
  ]
}