Input: Analysis of WT1 target gene expression in stably transfected cell lines.

WT1 target gene


Input: Some may affect the folding pathway or the affinity for chaperonins.

chaperonins


Input: Amniotic fluid ionic concentration in response to chronic fetal vasopressin infusion.

fetal vasopressin


Input: The use of bentonite in the compounding of hydrogels


Input: VBP and a1/EBP could mediate the high rates of ALV and RSV LTR-enhanced transcription in bursal lymphoma cells and many other cell types.

VBP

RSV LTR


Input: Insulin therapy has been expanded by development of human insulin and new modes of injection, including insulin pumps.

Insulin

human insulin

insulin


Input: Also, anti-HIV gp120 and anti-CD4 crosslinking induced a 10-15-fold increase in levels of both PI 3-and PI 4-kinase activity in anti-CD4 precipitates.

anti-HIV gp120

PI 3-and PI 4-kinase


Input: The genomic organization in this region is similar to the neural-restricted family members, Hel-N1 (ELAVL2) and mHuD (Elavl4).

mHuD


Input: Chronic active hepatitis and pregnancy.


Input: 42nd annual meeting of the American Academy of Oral Pathology.


Input: CONCLUSION: The biodistribution of 111In IgG is similar to that of 99mTc-HMPAO-labeled leukocytes.

IgG


Input: In vitro DNA binding assays indicate that the elements identified can specifically interact with c-Ets-1 protein.

c-Ets-1 protein


Input: The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT.

N-CoR

SMRT


Input: Since it is often necessary to resort to thoracotomy as a final step in making such a diagnosis, we have sought a procedure that is simpler while capable of providing the same information.


Input: On the optic tentacle-gonadal axis in the control of the male-phase ovotestis in the slug (Ariolimax californicus).


Input: The protein kinase C inhibitor GF-109203X abolished the activation by phorbol ester and inhibited the effect of CCK by 78% but had no effect on EGF-activated MAPK activity.

protein kinase C

CCK

EGF

MAPK


Input: Four multicannulated Holstein steers (initial BW 424 +/-16 kg) were used in a 4 x 4 Latin square to determine the influence of protein supplementation on forage intake, site and extent of digestion, and nutrient flow in steers consuming dormant bluestem-range forage (2. 3% CP).


Input: These morphological changes are associated with a marked induction of P450arom gene expression.

P450arom gene


Input: This residue, although located 55 rather than 35 residues NH2-terminal of the essential glutamate, is undoubtedly the analog of the second aspartate of the Asp-Asp-35-Glu motif found in other family members.


Input: DNase I protection analysis as well as oligonucleotide competition experiments indicate that this binding is sequence specific.

DNase I


Input: METHOD: After eligibility, patients were randomly allocated in one of the following groups: M = methylprednisolone 30 mg. kg-1 over 1 hour, followed by 5. 4 mg. kg-1. h-1 for 23 hours, N = nimodipine 0. 015 mg. kg-1. h-1 over 2 hours followed by 0. 03 mg. kg-1. h-1 for 7 days, MN or P.


Input: We have shown previously that EGF receptor activation stimulates gastrin gene expression through a GC-rich element called gERE.

EGF receptor

gastrin


Input: To determine cis-acting elements controlling the rat B-50/GAP-43 gene expression, the genomic DNA encoding exon 1 and the 5' flanking sequence was isolated.


Input: The traW gene of the Escherichia coli K-12 sex factor, F, encodes one of the numerous proteins required for conjugative transfer of this plasmid.

traW gene of the Escherichia coli K-12 sex factor


Input: Profilins IIa and IIb are also present in humans, suggesting that all mammals have three profilin isoforms.

Profilins IIa and IIb

profilin isoforms


Input: Results on the use of amiodarone in the prevention of paroxysmal AF have been equivocal; this may be attributed to differences in defining paroxysmal AF.


Input: Nuclear localization of this SNF2-like putative helicase is dependent on a nuclear localization sequence located in the NH2-terminal region.

helicase


Input: Expression of these chemokines is similar in that both require the NF-kappa B element and additional regions such as the CAAT/enhancer binding protein (C/EBP) element of the IL-8 promoter.

NF-kappa B element

CAAT/enhancer binding protein

C/EBP

IL-8 promoter


Input: Any opacity on a chest radiograph has a wide differential diagnosis.


Input: Levels of p53 were substantially increased by E1A expression during adenovirus infection.


Input: This pathway has been reported to mediate heterodimer interactions with the proapoptotic regulator, Bad.

Bad


Input: The toxicity of copper to the collembolan Folsomia fimetaria L. was studied in soil incubated with copper sulfate for different periods before the introduction of collembolans, to assess the effect of aging of contamination on the toxicity of copper.


Input: Earlier published data, indicating Sp1 binding to the R1 alpha/beta regions, could not be confirmed, suggesting that the R1 initiator element may function independent of Sp1.

R1 alpha/beta regions


Input: We sought to test whether a prolonged infusion of magnesium sulfate (MgSO (4); 40 mmol/24 hours) would normalize QT interval variability in patients with compensated heart failure.


Input: Using probes containing C/EBP-binding sites from the iNOS gene revealed further binding of different complexes, all of which were strongly inducible by cAMP and to a lower extent also by IL-1beta.

C/EBP-binding sites

iNOS gene


Input: Long-term follow-up of kidney donors: a longitudinal study.


Input: Gore & Associates, Inc.) standard wall graft segments varying in length from 4 to 12 cm.


Input: This report describes the isolation and recombinant expression of a cDNA clone encoding HER4, the fourth member of the human epidermal growth factor receptor (EGFR) family.

human epidermal growth factor receptor

EGFR


Input: Precision of data from models of sodium kinetics in hemodialysis


Input: Cytochrome bd biosynthesis in Escherichia coli: the sequences of the cydC and cydD genes suggest that they encode the components of an ABC membrane transporter.

Cytochrome bd

cydC

cydD genes

ABC membrane transporter


Input: We exposed Dorper-cross ewes at approximately 120-135 days of gestation to a hot (40 degrees C, 60% relative humidity) and a cold (4 degrees C, 90% relative humidity) environment and to treadmill exercise (2. 1 km/h, 5 degrees gradient) and measured fetal lamb and ewe body temperatures using previously implanted abdominal radiotelemeters.


Input: Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties.

human beta 2-adrenergic receptor


Input: A brief discussion for the relationship among these formulas is given.


Input: The embryology of the vertebral column is reviewed briefly, and the origin of each anomaly of the C2 vertebra is traced to one of the two early stages in development as follows: 1) the formation of the mesenchymal vertebra or 2) its induction to cartilage.


Input: Visualization of the cells by phase contrast microscopy indicated that murine PKCepsilon expression in the presence of glycerol resulted in a significant increase in the number of yeast cells exhibiting very small buds.

murine PKCepsilon


Input: 12 per cent was observed with the use of tetracycline and 4-epianhydrotetracycline in doses of 1000 and 100gamma per embryo respectively.


Input: The DNA-binding proteins are without effect on the transcription of plasmids lacking binding sites or when the binding sites are located further upstream.


Input: The duration of PGE2 and PGF2 alpha elevations as well as the peak values were influenced by day of the cycle.


Input: One hundred men who received alpha-tocopherol were matched on age, study center, and length of time between blood draws to 100 men who received a placebo.


Input: Serum angiogenin concentrations in young patients with diabetes mellitus.

Serum angiogenin


Input: Bodily referents and the experience of affect.


Input: We studied about the histological findings of the kidneys including of the infiltrated macrophages in one hour post-transplantation kidney biopsies (one hour biopsies) and re-biopsies on 11 patients.


Input: The human lbc oncogene product is a guanine nucleotide exchange factor that specifically activates the Rho small GTP binding protein, thus resulting in biologically active, GTP-bound Rho, which in turn mediates actin cytoskeletal reorganization, gene transcription, and entry into the mitotic S phase.

human lbc oncogene product

guanine nucleotide exchange factor

Rho small GTP binding protein

Rho

actin


Input: RESULTS: There were no significant differences in the mean serum vitamin A, E concentrations and vitamin E/cholesterol ratio between pregnant women with normal hemoglobin and hemoglobinopathies, while confounding variables that might affect serum vitamin levels i. e. maternal age, gravida, BMI, gestational age, hematocrit, hemoglobin, mean corpuscular hemoglobin concentration and blood group were not different.

hemoglobin

hemoglobinopathies

hemoglobin


Input: These data indicate that SB 203580 sensitive p38 MAP kinases are not involved in okadaic acid mediated increases in TRE DNA binding and transactivation.

p38 MAP kinases


Input: In contrast, group II showed a significant improvement in peak VO2 with rate adaptive AV delay compared to fixed AV delay programming (P less than 0. 05).


Input: This vector should be applicable for high-throughput characterization of new open reading frames found in genome sequencing.


Input: Each patient was seen for 5 to 13 postsurgical maintenance visits.


Input: Evidence for a role of Smad6 in chick cardiac development.


Input: The overall response rate including CR and PR was 23. 5% (4/17).


Input: Left ventricular responses to dopamine in dilated cardiomyopathy as assessed by two-dimensional echocardiography and compared with findings of thallium-201 scintigraphy.


Input: RESULTS: Lateral PF OA was more common than medial PF OA (P < 0. 0001).


Input: Moreover, we show that GATA-1 and Sp1 synergize from a distance in constructs designed to mimic the architecture of globin locus control regions and downstream globin promoters.

globin locus control regions

globin promoters


Input: After 5, 850 C14 BP, the decrease in Acer stands could be attributed to fire as suggested by the strong increase in Betula and by the delayed expansion of Pinus cembra.


Input: 4. 7 +/-0. 6 micromol. kg-1. min-1) but was not changed by training.


Input: A wide conservation of iscSUA genes in nature and evidence that NifU and NifS participate in the mobilization of iron and sulfur for nitrogenase-specific iron-sulfur cluster formation suggest that the products of the iscSUA genes could play a general role in the formation or repair of iron-sulfur clusters.

iscSUA genes

NifU

NifS

nitrogenase

iscSUA genes


Input: RET/PTC oncogenes, generated by chromosomal rearrangements in papillary thyroid carcinomas, are constitutively activated versions of proto-RET, a gene coding for a receptor-type tyrosine kinase (TK) whose ligand is still unknown.

RET

PTC

proto-RET

receptor-type tyrosine kinase

TK


Input: Diclofenac sodium: blood concentration of the slow-release form and influence on the metabolism of kallikrein.

kallikrein


Input: The unc-101, sli-1, and rok-1 genes encode a distinct set of negative regulators of vulval differentiation.

rok-1 genes


Input: Optimized USF and MYC DNA-binding sites, which differ in the nucleotides bordering the hexanucleotide box displace the E-C4 factor in competition assays but with lesser efficiency than the E-C4 site itself.

USF

MYC

E-C4 factor

E-C4 site


Input: Fluorescent in situ hybridization (FISH) analysis showed that the novel regions involved in the NFKB2 rearrangement originated from chromosome 7q34, thus implying the occurrence of a t (7; 10) (q34; q24) reciprocal chromosomal translocation.


Input: DESIGN: Intradermally injected human squamous cell carcinoma cells were grown to 40 to 80 mm3 in athymic nude mice and irradiated with 675-nm light (75 J/cm2, 75 mW/cm2) 24 hours after the intraperitoneal injection of SiPc IV (1. 0 mg/kg).


Input: The effects of space radiation are partially known on astronauts, but much remains to be discovered.


Input: First, the amino-terminal regulatory arm of the GDI binds to the switch I and II domains of Cdc42 leading to the inhibition of both GDP dissociation and GTP hydrolysis.

GDI


Input: There are two regulatory regions between the US3 and the US6 transcription units.

US6 transcription units


Input: In the virus-infected cells, translation of the M1 protein was reduced to 10 to 20% of that of the wild-type virus; however, the translation of neither the nucleoprotein nor NS1 was significantly interfered with, indicating the important role of NS1 in translational stimulation of the M1 protein.

M1 protein

M1 protein


Input: Thus, the predicted M3 ORF is a functional gene that encodes an abundant secreted protein which is a candidate for interacting with host cellular receptors or cytokines.


Input: There was a positive correlation between change from baseline in parietal lobe gray-matter cytosolic choline, expressed in terms of choline/creatine resonance ratios, and cognitive performance as measured with the Alzheimer' s Disease Assessment Scale Cognitive Subscale.


Input: The protein encoded by the NF2 gene has a similarity to ezrin, radixin and moesin (ERM) proteins that link membrane proteins to the cytoskeleton.

NF2 gene

ezrin

radixin

moesin

ERM


Input: 80 v-ets-encoded amino-acids located immediately after the v-myb/v-ets junction are not found in P54/56c-ets, the translation product of the c-ets proto-oncogene, nor in a set of cellular proteins of 64, 62, and 60 kDa related to but distinct from P54/56c-ets.

v-ets

v-myb

v-ets

c-ets proto-oncogene


Input: Secretogranin II (SgII) is a secretory polypeptide stored in large dense core vesicles of neuroendocrine and neuronal cells.

Secretogranin II

SgII


Input: In contrast translocation of G1 to the Golgi was not observed when G1 was coexpressed with NSm, although NSm itself was still detected in the Golgi.

NSm

NSm


Input: The results show that while a larger polypeptide substrate carrying the HD1/3C site was processed more efficiently than a polypeptide substrate carrying the POL/Zn site, cleavage of the synthetic peptide substrates containing these two cleavage sites occurred at similar efficiencies.

HD1/3C site

POL/Zn site


Input: GBF1 and GBF2 mRNA is present in light and dark grown leaves as well as in roots.

GBF2 mRNA


Input: In this technique, the posterior wall of the neopharynx consists only of the prevertebral tissue, while the flap forms the anterior and lateral walls.


Input: These data may indicate redundancy between members of the NGFI-B/Nurr1/Nor1 subfamily and could explain why no phenotypic disturbances have yet been found in mice in which the NGFI-B gene has been inactivated.

NGFI-B

NGFI-B gene


Input: Activation of the mitogen-activated protein kinase (MAPK) pathway enhances long-range transactivation by the beta-globin locus control region (LCR) (W.

mitogen-activated protein kinase

MAPK

beta-globin locus control region


Input: The gp41 peptide (Glu-Leu-Asp-Lys-Trp-Ala) fused to the C-terminus of Sj GST forms a loop stabilized by symmetry-related GSTs.

gp41 peptide (Glu-Leu-Asp-Lys-Trp-Ala)

Sj GST

GSTs


Input: The GST-CBL-LZIP fusion protein contains a binding site for the SH2 domain of the p85 subunit of phosphatidylinositol 3-kinase, which mapped to Tyr731, which is present in the sequence YEAM.

GST

CBL

LZIP

SH2 domain

p85 subunit

phosphatidylinositol 3-kinase


Input: The testes of 8 specimens of Triturus marmoratus were collected during each month of 1987 and processed for electron microscopy and light microscopy demonstration of testosterone (T) following the ABC (avidin-biotin peroxidase complex) method.

ABC

avidin-biotin peroxidase complex


Input: We have generated transgenic fly strains with mutations affecting specific TRA-2 isoforms to investigate their individual roles in regulating the alternative processing of doublesex, exuperantia and tra-2 pre-mRNA.

TRA-2 isoforms

doublesex

exuperantia

tra-2 pre-mRNA


Input: Few triers or users had received SLT counseling from their dentist despite high dental utilization rates.


Input: There has been no significant toxicity associated with repeated 5-FU instillation into the airway.


Input: He had complained of fever and right hypochondralgia 2 months after being operated for appendicitis.


Input: Thus, apoptosis in hematopoietic cells is the end result of a conflict between death and survival signals, rather than a simple death by default.


Input: Changes in testicular testosterone and acid and alkaline phosphatase activity in testis and accessory sex organs after induction of varicocele in Noble rats.

alkaline phosphatase


Input: The reconstituted RNA polymerases containing the mutant alpha subunits were examined for their response to transcription activation by cAMP-CRP and the rrnBP1 UP element.

RNA polymerases

cAMP-CRP

rrnBP1 UP element


Input: Changes in the greater omentum of mice of different strains after intraperitoneal immunization with sheep erythrocytes.


Input: In patients, 750 mL of saline lowered DL (CO) (-8%, P < 0. 01 versus baseline), D (M) (-10%, P < 0. 01 versus baseline), aldosterone (-29%, P < 0. 01 versus baseline), renin (-52%, P < 0. 01 versus baseline), and hematocrit (-6%, P < 0. 05 versus baseline) and increased V (C) (20%, P < 0. 01 versus baseline), without changing rap and wpp.

renin


Input: Reversible pressure-induced amorphization in solid C70: Raman and photoluminescence study.


Input: Antibodies against REAP-1 inhibit in vitro RNA editing reactions confirming its role in RNA editing.


Input: The more severe the CRF, the more likely that total HDL and HDL2 cholesterol will be low.

HDL

HDL2 cholesterol


Input: A conventional N-terminal signal sequence was not detected in the NodO protein.

NodO protein


Input: Mean CD4 percentages were lower postpartum (21. 9 +/-3. 4) than prepartum (45. 1 +/-6. 7) in all five patients studied, although proliferative responses to the mitogens phytohemagglutinin and pokeweed were unchanged during the study period.

mitogens phytohemagglutinin and pokeweed


Input: Significance of the determination of vascular tonus in the differential diagnosis of rheumatic and arteriosclerotic lesions of the heart and vessels in middle-aged and elderly persons with fibrillation arrhythmia


Input: The disease processes that affect transplant patients both before and after transplantation are not seen frequently in the general practice of gastroenterology.


Input: In Experiment 2, levels were: amprolium and ethopabate,. 02%; salinomycin, 55 mg/kg; monensin, 99 mg/kg; and lasalocid, 110 mg/kg.


Input: This duplicated genomic region is also linked tightly to D1Z2, a genetic marker containing a highly polymorphic VNTR (variable number tandem repeat) consisting of an unusual 40-bp reiterated sequence.


Input: The level of transcription generated by all of these activators is greater than the sum of the levels generated by individual factors, a phenomenon designated transcriptional synergy.


Input: Aspartame is a synthetic sweetener commonly used in soft drinks and many foods.


Input: Under control conditions and in the presence of 3 micromol/kg MIB and VER the maximal effect of noradrenaline was reached at 0. 1 micromol/kg whereas in the presence of 10 micromol/kg MIB and VER it was reached at a dose of 1 micromol/kg.


Input: The highly conserved region of U6 snRNA has a structural similarity with the catalytic domain of the negative strand of the satellite RNA of tobacco ring spot virus [(-) sTRSV], suggesting that the highly conserved region of U6 snRNA forms the catalytic center.

U6 snRNA

U6 snRNA


Input: By computed homology search, we noticed significant similarities between US3 PK and p21-activated kinase (PAK), which is activated by the Cdc42 or Rac.

US3 PK

p21-activated kinase

PAK

Rac


Input: Using transgenic lines a detailed analysis of the Hoxa-7 enhancer-directed expression during embryogenesis was performed. lacZ expression was first detected in the allantois at day 7. 5 p. c. and in mesoderm and ectoderm at day 8. 5 of gestation.

lacZ


Input: Its phosphorylation strongly potentiates its ability to activate transcription of the c-fos promoter through a ternary complex assembled on the c-fos serum response element.

c-fos promoter

c-fos serum response element


Input: Drosophila melanogaster casein kinase II (DmCKII) is composed of catalytic (alpha) and regulatory (beta) subunits associated as an alpha2beta2 heterotetramer.

Drosophila melanogaster casein kinase II

DmCKII


Input: Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor.

DNA topoisomerase II alpha gene

p53 tumor suppressor


Input: These conditions may determine an increase in the level of indoor pollutants (tobacco smoke, gases produced by cooling processes etc.) and of allergens derived from mites, domestic animals and cockroaches.


Input: Vav and Dbl are members of a novel class of oncogene proteins that share significant sequence identity in a approximately 250-amino-acid domain, designated the Dbl homology domain.

Vav

Dbl

Dbl homology domain


Input: METHODS: Levels of sIL-2R were measured simultaneously in plasma and pleural fluid in 111 patients with pleural effusions of unknown causes.


Input: HCVR-L significantly increased dVAS/dPCO2 to 4. 9 +/-0. 7 mm/Torr compared to HCVR-S (p < 0. 05).


Input: Right-sided hemiplegia of 5 years duration occurred in the remaining case.


Input: Studies on the excretion of selenium in urine and feces and distribution in the organs of rats by a method of radioactivity measurement


Input: The LIF appeared to be released by the patient' s peripheral blood lymphocytes when cultured with optimal doses of propranolol.

LIF


Input: In addition, the findings confirmed previous studies which showed that monkeys with total bilateral striatectomies could require the ability to execute accurate visually guided reaches.


Input: The greatest risk of preterm prelabour rupture of membranes (PPROM) is preterm delivery.


Input: The 2. 3 x 10 (3) base SUF12 + transcript contains an open reading frame sufficient to encode a 88 x 10 (3) Mr protein.

2. 3 x 10 (3) base SUF12 + transcript


Input: This regulation is mediated by several kinases that phosphorylate specific residues in the different functional domains of the p53 molecule.

p53 molecule


Input: In group I during the pain free period 26 of 81 patients had positive thallium-201 scans, whereas 20 patients had an abnormal ECG at that time; during angina 18 patients had transient ECG changes.


Input: We examined the contribution of the M-MuLV enhancers to the transcriptional activity and pathogenesis of M-MuLV by constructing LTRs containing heterologous enhancer elements.

M-MuLV enhancers


Input: Acute respiratory distress syndrome.


Input: Serum creatinine kinase activity was 7, 800-17, 500 U/l, making acute muscle damage likely, probably rhabdomyolysis.

creatinine kinase


Input: Transcriptional regulation of the murine k-fgf gene.

murine k-fgf gene


Input: Fetal arterial and sagittal sinus pH, base excess, po2, and oxygen saturation decreased, and hydrogen ion concentrations and pco2 increased during asphyxia alone and asphyxia plus isoflurane-oxygen.


Input: To clarify the difference, both the Crk II and Crk II-23, proteins were expressed in E. coli and examined their binding capacity in vitro.

Crk II

Crk II-23


Input: Growth hormone exerts its effects on the ovarian follicular cycle directly or by local production of insulin-like growth factor 1 (IGF-1).

Growth hormone

insulin-like growth factor 1


Input: For the most part, only aerobic microbial degradation systems have been reported so far.


Input: This is mediated by vascular remodeling, an active process that results in a change in the geometry of the blood vessel.


Input: The results suggest that the posterior wall is more compliant than the anterior wall (that is, for a given difference in transmural pressure, the local segment length change of the posterior wall was greater).


Input: Although cardiac output decreased slightly with PCF, hemodynamic changes due to PCF were unlikely to account for the observed fall in PaO2.


Input: Swarming of Moraxella


Input: Two patient groups were studied: Type I--with a new ePTFE graft; and Type II--with thrombectomy and/or revision of a previously placed ePTFE graft.


Input: No consensus binding sequence could be discerned in these fragments and bound factor is in rapid equilibrium with unbound.


Input: As a quantitative index of cochlear function, 2f1-f2 distortion-product otoacoustic emissions (DPOAEs) were monitored systematically over time in three groups of rabbits, with each group experiencing a unique paradigm that incorporated repeated exposure to the low-frequency tone.


Input: Quasidiatomic study of Ly-alpha-producing H2 +-Ne collisions at keV energies.


Input: Detailed analysis of the predicted amino acid sequence revealed sequence elements which are conserved in many DNA and RNA polymerases.

DNA and RNA polymerases


Input: 139La NQR relaxation and microSR study of Zn-doping effects in La2CuO4.


Input: We have previously reported the first isolation of a c-myc-null cell line.

c-myc-null


Input: Our study investigated the hypothesis that the combination of a high NaCl diet and social isolation stress would increase systolic blood pressure (SBP) and endogenous sodium pump ligands (SPL), ouabainlike compound (OLC), and marinobufagenin (MBG).


Input: Percentage incremental 18-OHB responses to metoclopramide were greater (P less than 0. 01) in the subjects after 5 days on a 200-meq sodium intake than after 5 days on a 10-meq sodium intake.


Input: An additional stimulation of D1 receptors by giving SKF38393 30 min later produced an almost continuous pattern of jaw openings but less closure movements from the rest position, and the openings were accompanied by frequent tongue protrusions.

D1 receptors


Input: PURPOSE: Second malignant neoplasms (SMNs) are a rare occurrence after the successful treatment of childhood cancer.


Input: A p53 cDNA deletion mutant (delta pro AE), which lacks this entire proline-rich domain (deleted for amino acids 62-91), was created and characterized for a variety of p53 functions.

p53 cDNA


Input: Mutations in nifR1 (ntrC) and nifR4 (rpoN, encoding sigma54) had no influence on xdh gene expression.

ntrC

rpoN

xdh gene


Input: Candidate factors have been identified by the observation that changes in glucocorticoid induction parameters in CV-1 cells could be reproduced by varying the cellular levels of coactivators [transcriptional intermediary factor 2 (TIF2), steroid receptor coactivator 1 (SRC-1), and amplified in breast cancer 1 (AIB1)], comodulator [CREB-binding protein (CBP)], or corepressor [silencing mediator for retinoid and thyroid-hormone receptors (SMRT)] without concomitant increases in GR.

transcriptional intermediary factor 2

steroid receptor coactivator 1

amplified in breast cancer 1

CREB-binding protein

CBP

silencing mediator for retinoid and thyroid-hormone receptors

SMRT

GR


Input: The pyridostigmine inhibited AChE recovered only in the 100 mumol kg-1 kg oxime groups at the end of the experiment.

AChE


Input: We compared retrospectively the efficacy of granulocyte colony stimulating factor (G-CSF) alone with chemotherapy plus G-CSF in mobilizing CD34-positive cells in patients with malignant lymphoma.

granulocyte colony stimulating factor

G-CSF

G-CSF


Input: An additional dose of 20-25 Gy was delivered to the site of original involvement using an implant when feasible.


Input: Activation of the receptor induces Ret phosphorylation that leads the survival-promoting effects.

Ret


Input: Adenovirus infection of hepatoma cells inhibited transcription of the phosphoenolpyruvate carboxykinase (GTP) (EC 4. 1. 1. 32) (PEPCK) gene and virtually eliminated transcription of a chimeric gene which contained the PEPCK promoter linked to the structural gene for chloramphenicol acetyltransferase (CAT).

phosphoenolpyruvate carboxykinase

EC 4. 1. 1. 32

PEPCK

PEPCK promoter

chloramphenicol acetyltransferase

CAT


Input: Circulating immune complexes were determined by the method of phagocytosis and immunofluorescence.


Input: LCCH1 was identical to the Rdl gene, a known GABA receptor subunit gene from D. melanogaster, whereas LCCH2 and LCCH3 were novel D. melanogaster sequences that exhibited structural similarity to other members of the ligand-gated chloride channel gene family.

Rdl gene

GABA receptor subunit gene

ligand-gated chloride channel gene family


Input: In this report, we investigated whether the cleavage of the RRKR motif of MT-MMP1 by Golgi-associated furin is analogous to a similar enzyme activation mechanism observed with stromelysin-3.

Golgi-associated furin


Input: Lifestyle characteristics were ascertained by a self-administered questionnaire.


Input: The oxalate oxidase method results in a mean and reference interval for oxalate excretion that are comparable with those by isotope dilution, gas-chromatographic, colorimetric, and other enzymic procedures.

oxalate oxidase


Input: Normal replication of DNA A still carrying the AC3 ORF mutation was found in extracts from these plants.

DNA A

AC3 ORF


Input: Kohtz, J.


Input: These data are discussed in the context of the pathogenesis and differential diagnosis of EEC.


Input: These data suggest that the fibrinogen gamma chain region Gly190-Val202 functions as a minimal recognition sequence for the leukocyte integrin CD11b/CD18.

fibrinogen gamma chain region Gly190-Val202


Input: OBJECTIVE: The audiologic presentation of vestibular schwannoma (VS) associated with neurofibromatosis type 2 (NF2) has not been well characterized.


Input: Siglec-9 is predicted to contain three extracellular immunoglobulin-like domains that comprise an N-terminal V-set domain and two C2-set domains, a transmembrane region and a cytoplasmic tail containing two putative tyrosine-based signaling motifs.

immunoglobulin-like domains

N-terminal V-set domain

C2-set domains


Input: Development of P carinii pneumonia was associated with the stage of Kaposi' s sarcoma, B subtype disease, and the presence of 0. 20 X 10 (9)/L (200/mm3) or fewer CD4 cells at study entry.


Input: Dermatophagoides farinae-sensitized lymphocytes in asthmatic children as evaluated by interleukin-2 (IL-2) production and acquisition of IL-2 responsiveness


Input: Adenocarcinoma and large cell carcinoma have a worse prognosis than squamous cell carcinoma in the T1N1 and T2N1 subsets.


Input: The DNA element through which EBNA-3C activates the LMP-1 promoter includes a Spi-1/Spi-B binding site, previously characterized as an important EBNA-2 response element.

LMP-1 promoter

Spi-B

EBNA-2 response element


Input: Based on PCR strategies and expression studies, we define the genomic organization of the FUT8b gene.

FUT8b gene


Input: Cord formation in BACTEC 7H12 medium for rapid, presumptive identification of Mycobacterium tuberculosis complex.


Input: The effect of the NMDA-receptor antagonist (+/-)-CPP on the conditioned-reflex activation of an operant reaction in the brain electrical self-stimulation test in rats

NMDA-receptor


Input: Treatment with H7 did not affect IL-4R-mediated immediate signaling events such as tyrosine phosphorylation of Jak1, Jak3, insulin receptor substrate (IRS)-1 and IRS-2, or tyrosine phosphorylation and DNA binding of Stat6.

insulin receptor substrate (IRS)-1


Input: Vasodilation in congestive heart failure is an established therapeutic principal.


Input: The translational product of UL26. 5 is infected-cell protein 35c, d (ICP35c, d) (F.

UL26. 5

infected-cell protein 35c, d

ICP35c, d


Input: Our experience suggests that T2 weighting is adequate and is the method of choice for the early recognition of necrosis of the lunate.


Input: Minor changes within the transmembrane domains (TMs) sometimes produced major effects and more drastic changes in the TMs ablated surface expression entirely.


Input: Molecular analysis of the mannitol operon of Clostridium acetobutylicum encoding a phosphotransferase system and a putative PTS-modulated regulator.


Input: Mammalian chromosome ends contain long arrays of TTAGGG repeats that are complexed to a telomere specific protein, the TTAGGG repeat binding factor, TRF1.

TTAGGG repeat binding factor


Input: HPV-16 MARs are context dependent transcriptional enhancers, and activated expression of HPV-16 oncogenes dependent on chromosomal integration may positively select tumorigenic cells during the multistep etiology of cervical cancer.


Input: Vancomycin and tetracycline eliminated toxin in stools and delayed death.


Input: This combination is considered pathognomonic for factitious hyperinsulinism.


Input: The duration of naloxone appears to be dose-related, statistically significant up to approximately 1. 5 hr.


Input: In the present study, we report the entire genomic structure of KCNQ1, which consists of 19 exons spanning 400 kb on chromosome 11p15. 5.


Input: A comparison between attenuation-corrected and-uncorrected transmission-emission SPECT images obtained with Tl-201 in CAD patients


Input: Reconstruction time for a 64 x 64 matrix is approximately 45 s/transaxial slice.


Input: The hyperpigmentation is linked to the presence of numerous single melanosomes and polymelanosomes in keratinocytes at all levels of the epidermis, and in dermal Factor XIIIa-positive dendrocytes.

Factor XIIIa


Input: The immediate and remote results of surgical treatment of renal adenocarcinomas.


Input: Six patients underwent an electrophysiologic study.


Input: In agreement with this, archaea appear to lack eIF5, eIF2B and the lysine-rich binding domain for these factors in their eIF2beta homolog.

eIF2beta homolog


Input: However, the MCMI-III group profile was significantly lower in magnitude compared with the MCMI-II.


Input: Spen is the only known homeotic protein with RNP binding motifs, which indicates that splicing, transport, or other RNA regulatory steps are involved in the diversification of segmental morphology.

Spen

homeotic protein


Input: The existence of universal non-specific mechanism of action of external factors upon the living tissue based on the DEL-reaction is suggested.


Input: The impairment of the nocturnal secretion was related to the subjects' age and, for the GH secretory pattern only, also to the MMSE score.

GH


Input: In this study, we cloned the full-length cDNA of mouse PAX4 by RACE (rapid amplification of cDNA ends) using RNA from MIN6 cells, a mouse insulinoma cell line.


Input: Sixteen patients (25. 4%) encountered rejection while weaning at median period of 9. 5 months (range, 1-63 months) from the start of weaning.


Input: Earlier nonoptical methods probably did not include the portion of the film that contained mucus.


Input: Antibodies specific to the different members of the Jun and Fos family of transcription factors show that, in gel retardation assays, a Jun-like factor is a component of the H3. 2 specific complex.

Jun

Fos family of transcription factors

Jun-like factor

H3. 2 specific complex


Input: CONCLUSIONS: Results of this study suggest that both male and female soldiers who are diagnosed with chlamydia infections have relatively high risks of reinfection through their 20s.


Input: Here we report that point mutations of the Abd-B gene in trans suppress the Fab-7 phenotype in a pairing-dependent manner and thus represent a type of transvection.

Abd-B gene

Fab-7 phenotype


Input: The glucose effect on the pyruvate kinase gene is reversibly antagonized by agents increasing intracellular cAMP.

pyruvate kinase gene


Input: Here, we report the isolation of a new spindle checkpoint gene, mph1 (Mps1p-like pombe homolog), in the fission yeast Schizosaccharomyces pombe, that is required for checkpoint activation in response to spindle defects. mph1 functions upstream of mad2, a previously characterized component of the spindle checkpoint.

Mps1p-like pombe homolog


Input: In addition, measurements of shielded and unshielded syringes containing 99mTc-labelled radiopharmaceuticals were carried out.


Input: Combination chemotherapy in advanced ovarian cancer.


Input: The results in the untreated patients demonstrate the primary importance of bulk reduction at initial laparotomy.


Input: Vertebrate U6 small nuclear RNA (snRNA) loci exemplify a novel class of polymerase III-transcribed genes that lack an intragenic control region (ICR).

U6 small nuclear RNA

polymerase III


Input: The well-trained group was measured once in the respiration chamber for 36 h according to the same protocol.


Input: PtdIns (4, 5) P2 synthesis, on the other hand, is only moderately affected even in fab1Delta mutants.

PtdIns (4, 5) P2

fab1Delta mutants


Input: Protein sequencing, electrophoretic mobility shift assay, and immunoblot analyses identify p54 and p47/48 as members of the hepatocyte nuclear factor 3 (HNF3 [forkhead]) family of transcription factors. p54 belongs to the subfamily of HNF3 beta proteins, while p47/48 binding activity includes HNF3 gamma.

hepatocyte nuclear factor 3

forkhead

HNF3 beta proteins

HNF3 gamma


Input: Molecular analysis indicated that inactivation of H-2L expression in nearly every null clone resulted from an apparent deletion or rearrangement of 5'-flanking and 5'-coding H-2L sequences, with breakpoints consistently mapping to within a 550 bp GC-rich region between exon 1 and the middle of intron 2.

5'-flanking and 5'-coding H-2L sequences


Input: CBD exploration was avoided in 7 patients with normal POC.


Input: These mutations prevent FKBP12-rapamycin binding to TOR2, as assayed with the two-hybrid system.


Input: The psbA gene encodes the D1 protein of photosystem II, which is synthesized at very high rates in the light in order to replace photodamaged protein.

psbA gene

D1 protein

photosystem II


Input: The TCR beta enhancer was active on both the minimal simian virus 40 promoter and a TCR beta variable gene promoter in both TCR alpha/beta + and TCR gamma/delta + T cells.

TCR beta enhancer

minimal simian virus 40 promoter

TCR beta variable gene promoter

TCR alpha/beta

TCR gamma/delta


Input: Fibrosis of the adjacent myocardium was seen in five cases.


Input: Symptoms, skin-prick tests (SPT) with environmental allergens and Pt salt, total serum IgE, lung function, and bronchial hyperresponsiveness were assessed by standard procedures.

serum IgE


Input: These findings suggest that T3R can repress or activate transcription while tethered to the LBD of GAL4-RXR and that heterodimerization can occur in vivo without stabilization by hormone response elements.

RXR


Input: During 4% O2 ventilation, baseline pulmonary vascular resistance (PVR) and the dilator response to both ACh and SNP were greater in 2D lungs.


Input: HGF treatment increased cyclin A, cyclin G1 and nuclear transcriptional factor (NFkappaB) protein expression.

HGF

cyclin A

cyclin G1

NFkappaB


Input: Surprisingly, in adult animals, the suprabasal expression of dnRXR alpha significantly reduced the ability of topically applied tRA to stimulate proliferation of undifferentiated keratinocytes in the basal layer of epidermis.

dnRXR alpha


Input: A third-order polynominal fit showed a good correlation for the parameter Q * and MTT, whereas T and SImax were found to have a poor correlation.


Input: This article focuses on a general approach to the use of ARV agents.


Input: Although FKH2 is redundant with FKH1 in controlling pseudohyphal growth, the two genes have different functions in silencing HMRa.

HMRa


Input: These results demonstrate the extensive homology in sequence among light chains of IgM kappa autoantibodies and indicate that a particular V kappa germ line gene, kappa IIIb, is expressed as a phylogenetic response to certain self antigens or as part of a selection process by which these autoimmune responses are regulated.

IgM kappa autoantibodies

V kappa germ line gene

kappa IIIb


Input: The aim of the present study was to investigate the influence of long term intravenous administration of naftidrofuryl (Dusodril-Lipha Arzn) twice daily in a dose of 200 mg in continuous, 4-hour infusion in 500 ml 0. 9% NaCl to the patients suffering from a peripheral arterial occlusive disease (PAOD) in a clinical condition with special attention paid to transcutaneous partial oxygen pressure measurements (tcPO2) and rheographic parameters.


Input: We concluded that RXR-gamma induced terminal differentiation in SCC lines, suggesting a potential tumor suppressor function for this transcription factor.

RXR-gamma


Input: Finally, there is now appropriate recognition of the pivotal role of BP reduction in forestalling pressure-related cardiovascular complications, even among high-risk persons with diabetes mellitus and renal insufficiency.


Input: RNA determinants required for L4-mediated attenuation control of the S10 r-protein operon of Escherichia coli.

S10 r-protein operon of Escherichia coli


Input: The psh3 (+) gene encodes a protein of 215 amino acids, which shares a high degree of structural and functional similarity with Shr3p.

psh3 (+) gene


Input: A very large PC LAN as the basis for a hospital information system.


Input: A rapid mixing device for quasielastic light scattering studies of reacting systems.


Input: After institution of insulin treatment, diabetic control was improved as demonstrated by decreasing levels of HbA1.

insulin


Input: It is not tested yet, whether the extent of glaucoma damage should be better quantified using reference plane 1 or 2.


Input: Based on the deduced amino acid sequence identity we designated GAPC1 and GAPC2 as group I (97% identical) and GAPC3 and GAPC4 as group II (99. 4% identical).


Input: In analogy to human CD70, mCD70 transcript levels are strongly but transiently up-regulated during lymphocyte activation, which is in line with a role for the CD27-CD70 receptor pair early in the immune response.

human CD70

mCD70 transcript

CD27-CD70 receptor


Input: Both parameters were determined in an individual eye by applying the dye first by iontophoresis and then by intravitreal injection, which allows the influence of fluorescein glucuronide on the fluorophotometric measurements to be excluded.


Input: Phase I clinical trial with a combination of methotrexate and mitomycin C.


Input: A total of 114 animals were infected by E. coli O2: K1: H4 by the hematogenic route.


Input: Expression of a cDNA clone in yeast containing a large portion of the open reading frame produced cAMP PDEase activity identical in properties to the Drosophila enzyme affected by the dnc mutation.

cAMP PDEase

dnc mutation


Input: CONCLUSIONS: These results suggest that, by interacting with cellular transcription factors and cofactors, vIRF-2 may modulate the expression of the early inflammatory genes and potentially deregulate the immune system.


Input: It has been demonstrated that stimulation of the pontomesencephalic parabrachial region (PBR) by microinjection of cholinergic drugs or electricity in the cat produces potent pain suppression which is not antagonized by the opiate antagonist, naloxone.


Input: AIMS: The aim of this study was to assess static and dynamic bone changes in patients suffering from rickets.


Input: The homeodomain transcription factor CDP/cut interacts with the cell cycle regulatory element of histone H4 genes packaged into nucleosomes.

homeodomain transcription factor CDP

cut

histone H4 genes


Input: K., Weiss, M.


Input: Thus, IF-laser therapy has a certain antioxidative effect by increasing SOD activity in RA patients' blood cells and reducing the production of highly reactive oxygen and nitrogen forms.

SOD


Input: During hexamethylene bisactamide (HMBA)-induced differentiation of murine erythroleukemia (MEL) cells erythroid genes are transcriptionally activated while c-myb and several other nuclear proto-oncogenes are down-regulated.

c-myb


Input: We now report identification and analysis of transcriptional activities mediated by three cis-acting sites within a 90-bp portion of the rDNA enhancer designated the modulator region.


Input: Background reduction with various agents had a prominent effect on DTIn1 as well as 99mTc-DTPA biodistribution.


Input: Influence of copper addition.


Input: In human WI38 cells, the E1B 19K gene mutant viruses had a substantial growth advantage over the wild-type virus, yielding 500-fold-higher titers.

E1B 19K gene mutant


Input: The cooperation between health and hospital services


Input: The N-terminal sequence of the extracellular MEP20, TKVAS, was found at aa 194-198 within the ORF.

extracellular MEP20

TKVAS


Input: Furthermore, mutations in element II result in changes in the RNA structure near element III, consistent with a long-range interaction that may promote translation.


Input: (We observed a ferritin value as high as 47 mg/L in one patient.) Results with all these kits did not inter-compare well for ferritin concentrations greater than 300 micrograms/L, a finding that casts further doubt on the controversial use of serum ferritin measurement in cases of iron overload.

ferritin

ferritin

serum ferritin


Input: Most other differences between these two Leporipoxviruses are located in the telomeres.


Input: The Tat protein coded by human immunodeficiency virus (HIV) is a strong activator of viral gene expression from the long terminal repeat (LTR).

Tat protein


Input: A.


Input: This case report describes the treatment of a patient with periodontosis.


Input: Upstream tissue inhibitor of metalloproteinases-1 (TIMP-1) element-1, a novel and essential regulatory DNA motif in the human TIMP-1 gene promoter, directly interacts with a 30-kDa nuclear protein.

tissue inhibitor of metalloproteinases-1 (TIMP-1) element-1

human TIMP-1 gene promoter


Input: We propose that U73 is involved in methylation of the G1739 residue of the human 28S rRNA.

human 28S rRNA


Input: Also, the placebo nondepressed patients had significantly better treatment outcome compared with the placebo depressed patients.


Input: Animals were divided into six equal groups as follows: (1) no oral drug (water), no hemodilution, no IV drug (saline); (2) oral water, hemodilution, IV saline; (3) oral water, no hemodilution, IV propranolol; (4) oral water, hemodilution, IV propranolol; (5) oral propranolol, no hemodilution, IV saline; and (6) oral propranolol, hemodilution, IV saline.


Input: We found 4 highly conserved regions to vertebrate Hsp90 exclusively and 27 amino acids conserved among but differing between Hsp90 alpha and Hsp90 beta sequences.

vertebrate Hsp90

Hsp90 alpha

Hsp90 beta sequences


Input: Four newborns in this group became HBsAg carriers.

HBsAg


Input: It tends to be higher between frazioni of the same community than between communities.


Input: In previous studies, we showed that the nuclear import of SREBP-2 occurs via the direct interaction of importin beta with the HLH-Zip domain.

importin beta


Input: The destruction of the mesometrium did not lengthen the oestrous cycle.


Input: Ftz, on the other hand, influences Ftz-F1 activity by interacting with its AF-2 domain in a manner that mimics a nuclear receptor coactivator.

Ftz

Ftz


Input: Type C units summate the responses to the two-tone stimulus, and show little or no inhibitory influences.


Input: 19, 4967-4973).


Input: CONCLUSIONS: In the majority of patients with severe ulcerative colitis, circulating concentrations of NOX are increased at presentation and fall promptly during parenteral steroid therapy, irrespective of clinical outcome.


Input: A cDNA for human microfibril-associated glycoprotein-2 (MAGP-2) was used to screen a human leukocyte genomic DNA library in EMBL-3 vector.

human microfibril-associated glycoprotein-2


Input: Screening of a human foetal brain genomic DNA library allowed us to isolate an EcoRI-EcoRI fragment containing 6 kb of the 5'-flanking region, the open reading frame and 4 kb of the 3'-flanking region of the alpha2C4 gene.

EcoRI

EcoRI

alpha2C4 gene


Input: Using gel retardation analysis, four binding sites for Rap1p have been identified within the promoter of the RAP1 gene.

RAP1 gene


Input: They are transduced through TM to the cytoplasmic portion (cytoloops and the C-terminal tail) of the receptor and then, transferred to cytoplasmic signaling molecules, such as G protein.

G protein


Input: Sgs-4 is one of the eight known genes coding for larval secretion proteins in Drosophila melanogaster.


Input: Unlike CSK, the SH3 domain of HYL was unique since the ALYDY motif was absent.

CSK

SH3 domain

HYL


Input: This enzyme is distinct from other known E3s, including E3 alpha/UBR1, E3 beta, and E6-AP.

E3 alpha

E3 beta


Input: RESULTS: Although low levels of vIRF-2 mRNAs can be detected in the HHV-8-positive BCBL-1 tumor cell line, 12-0-tetradecanoylphorbol-13-acetate (TPA) treatment does not stimulate expression of vIRF-2 gene together with primary lytic cycle genes.

vIRF-2 mRNAs

vIRF-2 gene


Input: Primary TJRs were clinically evaluated for degree of osteoarthrosis.


Input: We suggest that this relatively small deletion affects a segment containing 3' VH genes with important regulatory functions, the loss of which leads to the ali phenotype.

3' VH genes


Input: Apoptosis triggered through Fas and F/F was inhibited by coexpression of CrmA and p35, but not Bcl-xL.

Fas

F/F

CrmA

Bcl-xL


Input: Expression of Helios was detected in the earliest hematopoietic sites of the embryo, in hematopoietic stem cells in the adult and was subsequently restricted to a subset of cells in the T cell lineage.

Helios


Input: It produced extrapyramidal disturbances in nearly every subject, the most common being akathisia and the most severe, in the case of one individual, being acute dystonia.


Input: Electron microscopy of pH 7. 5-treated TMV particles incubated in SPN-treated wheatgerm extract or rabbit reticulocyte lysate, showed that approximately 10% of virions complexed with one ribosome and approximately 10% with two bound ribosomes, confirming that omega at least had been uncoated.

SPN


Input: The absorbance of the eluent was monitored at 254 nm.


Input: As anticipated, both intracellular p54-SAPKbeta activation and Bcl-2 phosphorylation are blocked by co-transfection with the MAP kinase specific phosphatase MKP3/PYST1.

SAPKbeta

MAP kinase


Input: All patients studied were pregnant women and their delivered children.


Input: PRP20 is related, both in structure and function, to the RCC1 gene of mammals and the PIM1 gene of Schizosaccharomyces pombe, both of which appear to regulate entry into mitosis and chromosome condensation.

RCC1 gene

PIM1 gene


Input: Using this oligonucleotide as a probe, an 8-kilobase HindIII fragment of genomic DNA was isolated and subjected to Sanger dideoxy DNA sequencing.

HindIII


Input: The Rep proteins of adeno-associated virus type 2 (AAV) are known to bind to Rep recognition sequences (RRSs) in the AAV inverted terminal repeats (ITRs), the AAV p5 promoter, and the preferred AAV integration site in human chromosome 19, called AAVS1.

Rep proteins

Rep recognition sequences

RRSs

AAV p5 promoter


Input: The electrocardiogram in tachycardia.


Input: It is noteworthy that under more physiological conditions mimicking the cellular GDP/GTP ratio, Raf enhances the GEF-stimulated GDP/GTP exchange on Ha-Ras, in agreement with the sequestration of Ras. GTP by Raf.

Raf

GEF

Ha-Ras

Ras. GTP

Raf


Input: In this study, we show that HNF-4, a member of the steroid hormone receptor superfamily, binds the AF-1 site on the apoB promoter and through it activates transcription in transient transfection assays in both liver and non-liver cell lines, HepG2 and HeLa, respectively.

steroid hormone receptor superfamily

AF-1 site

apoB promoter


Input: In Cos 7 cells transfected with oCRF1var, cAMP accumulation was only observed at the highest concentration of oCRF utilized (100 nM).

oCRF


Input: Usefulness of glucocorticoids in the treatment of congestive heart failure


Input: RESULTS: In 76 trials, 5, 351 patients received 24 different regimens of droperidol.


Input: The local median scores (ranges) of the above tests were as follows-AMT: 9 (6-10); CMMS: 25 (16-28); SBT: 2 (0-10); WL-i: 17 (8-27); WL-d: 5 (0-10); WL-r: 9 (1-10); ST: 13 (6-25); BNT: 14 (10-15); CPT: 1 (0-3); BDT: 19 (0-42); OAT: 20 (3-33).


Input: The organization of the MBP-A gene is very similar to the arrangement of the gene encoding the highly homologous pulmonary surfactant apoprotein, although one of the intron positions is shifted by a single amino acid.

MBP-A gene

homologous pulmonary surfactant apoprotein


Input: Plasma renin activity in essential arterial hypertension.

Plasma renin


Input: In vitro, cytokine-or hypoxia-induced up-regulation of Fas expression is associated with RTC apoptosis.

Fas


Input: These results suggest that the Reg1-Glc7 phosphatase is a cytoplasmic component of the machinery responsible for returning Snf1 kinase activity to its basal level and reestablishing glucose repression.

Snf1 kinase


Input: To explore further the role of the carboxyl-terminal domain in determining the cell cycle function of CDC34, we constructed and characterized genes encoding chimeric E2s incorporating sequences from CDC34 and the related but functionally distinct E2 RAD6 (UBC2).

chimeric E2s

E2 RAD6


Input: In F9, which is a prototype of embryonal carcinoma cells expressing hst, the expression of hst gene is positively regulated by a downstream octamer motif that functions as an enhancer.

hst

hst gene


Input: Furthermore, rubella IgM antibody was never detected after immunization in women who were HAI-negative and LA-positive during pregnancy.

rubella IgM antibody


Input: Since simian virus 40 (SV40) large T antigen and human papillomavirus type 16 (HPV16) E7 protein also bind host regulatory factors, we investigated whether these viral proteins can complement E1A mutants which are defective in early gene activation.

simian virus 40 (SV40) large T antigen

human papillomavirus type 16 (HPV16) E7 protein

E1A mutants


Input: Only viable bacteria at a high concentration induced purulent otitis media, which was culture positive in 58% of the cases on day 4.


Input: Results indicated that hobbies/leisure activities, mobility, transport, social relationships, working capacity, energy and doing things slower were aspects relevant to IPF patients' QOL.


Input: Residues that affect PLCbeta and adenylyl cyclase II activity are found on opposite sides of the central tunnel, suggesting that PLC and adenylyl cyclase, like the alpha subunit, make many contacts on the top surface.

PLCbeta

adenylyl cyclase II

PLC

adenylyl cyclase


Input: One new ORF, YBR0224, was detected, coding for a protein with 918 amino acids.


Input: The law and the chiropractor.


Input: A distinct 5'-sequence in clone hMIWC2 suggested an alternative upstream transcription initiation site.


Input: Rectal temperatures after the walk were greater (P <. 001) in native Simmental (39. 87 +/-. 05 degrees C) than in Bos indicus (39. 46 +/-. 05 degrees C).


Input: 98, 93-98).


Input: However, the pre3-2 mutation strengthened phenotypes induced by other 20 S proteasomal mutations, indicating that the peptidylglutamyl peptide-hydrolyzing activity has to fulfill some rescue functions.

pre3-2 mutation

20 S proteasomal mutations


Input: A mammalian protein called RFX or NF-X binds to the X box (or X1 box) in the promoters of a number of major histocompatibility (MHC) class II genes.

RFX

NF-X

major histocompatibility (MHC) class II genes


Input: This result suggests that the target protein specificity of E2s can be altered by the addition of appropriate C-terminal extensions, thus providing a way to modify the selectivity of the ubiquitin system.

ubiquitin


Input: This pattern of expression and differential processing suggests a role for inrpk1 in some aspect of SD photoperiodic-induced flowering in morning glory.


Input: Co-expression of a gag-TRalpha fusion protein in AEV-transformed cells and addition of ligand derepresses CAII transcription.

gag

TRalpha

CAII


Input: A 400-bp fragment (bp-339 through + 71) of the CD22 promoter region was subcloned into a pGEM-chloramphenicol acetyltransferase vector and after transfection into B and T cells was found to be active in both B and T cells.

CD22 promoter region

chloramphenicol acetyltransferase


Input: This suggests that the duration of varicocele per se could affect DHT seminal plasma levels.


Input: Five RNA transcripts of about 1. 2 to 1. 7 kilobases were mapped to a part of the genome of insect iridescent virus type 6 (Chilo iridescent virus; CIV) between genome coordinates 0. 832 and 0. 856 within the EcoRI DNA fragment F.

EcoRI DNA fragment F


Input: Cutting the intraorbital nerves produced a temporary retrieval impairment that was indistinguishable from that produced by intramystacial lidocaine injection.


Input: The comparisons of swimming performance before and after treatments with deltamethrin have shown a significant effect on locomotory ability of rainbow trout which at the end of strong exposure (e. g.


Input: Increased trabecular spacing, such as it occurs in osteoporosis, reduces the spatial field inhomogeneity and thus prolongs T2 *, which has been shown both in vitro and in vivo.


Input: Decidual/trophoblast prolactin-related protein: characterization of gene structure and cell-specific expression.

Decidual/trophoblast prolactin-related protein


Input: Thus, the cognitive performance of elderly subjects could be trained to a large extent.


Input: The map is based on the CEPH reference pedigrees and includes over 4000 new genotypes, our previously reported data plus 29 allele systems from the published CEPH version 5 database, and was constructed using the program package CRI-MAP.


Input: RMR was positively correlated with TEF (r = 0. 613, p < 0. 01) and net TEF (r = 0. 648, p < 0. 005) in the luteal but not the follicular phase.


Input: 132 varix ligations were performed during 44 separate EVL sessions.


Input: Nine individuals who were stable after 1 month of therapy at low dosage were randomized to a further month of therapy at low or high dosage, during which one of four at high dosage had a partial response, and none of five at low dosage manifested response.


Input: A factor present in nuclear extracts of wounded potato tubers was found to bind specifically to nucleotides located between-135 to-105, suggesting that this region contains important cis-regulatory elements.


Input: Two genes from the family encoding mouse ribosomal protein S16 were cloned, sequenced, and analyzed.

mouse ribosomal protein S16


Input: Bile reflux demonstrated by 99m Tc disofenin.


Input: The mode of action is often suggested as an explanation for the different slopes of concentration-effect curves.


Input: Two full-length clones (pBCH1 and pBCH2) were isolated.


Input: In dehydrated animals at Ta 38 degrees C, Tb and EWL were both significantly altered (P less than 0. 001) from the normally hydrated state and were measured at 39. 9 +/-0. 2 degree C and 0. 84 +/-0. 09 W. kg-1 respectively.


Input: The optimum cooling rate from RT to 5 degrees C resulting in maximum survival of human spermatozoa was found to be 0. 5 to 1 degree per minute when cooled from RT to 5 degrees C and subsequently frozen-thawed in liquid nitrogen (LN2).


Input: Replacement of a valine (V68) in the ETS domain of SAP1a by aspartic acid (as found in c-Ets-1, Elk-1, and Net) enhanced ternary complex formation by more than 60-fold.

ETS

Net


Input: Methylprednisolone and U-74006F were equally effective at preventing neurological dysfunction compared to the control group (p less than 0. 01); U-78517F was slightly less effective than U-74006F and methylprednisolone but was significantly better than vehicle in preventing neurological dysfunction.


Input: Comparison between the Ricketts and Bimler therapeutic technics in the treatment of cases of class II, division I mmalocclusion


Input: Sample size requirement for repeated measurements in continuous data.


Input: Transfection assays using the first 600 bp of the upstream nucleotide sequences indicated that a region from-75 to-120 was necessary for the ALDH2 gene expression, and especially NF-Y/CP1 binding site from-92 to-96 (CCAAT box) is important in the expression of the gene.

ALDH2 gene

NF-Y


Input: We report five of 13 evaluable patients undergoing allogeneic sibling BM or PBSC transplantation for MM between 1990 and 1997 who met the criteria for adjuvant alpha-IFN therapy.

alpha-IFN


Input: Both the 5' and 3' untranslated regions also show significant similarity to the murine gene, with 79 and 70% sequence identity, respectively.


Input: Plasma Pi, tibia breaking strength, and percentage of tibia ash were increased by raising dietary Pav in the presence of. 392% A1 with either level of Ca.


Input: A minimal region which stimulates origin function mapped to 50 amino acids within the C-terminus of Abf1p.


Input: Hepatocyte growth factor (HGF) is an inducible cytokine that is essential for the normal growth and development of various tissues, such as the liver.

Hepatocyte growth factor

HGF


Input: OBJECTIVE: To summarise quantitatively the association between moderate alcohol intake and biological markers of risk of coronary heart disease and to predict how these changes would lower the risk.


Input: (1991) EMBO J.


Input: Tissue-specific gene regulation of eukaryotic organisms is to a large extent mediated by transcription factors that interact with genomic DNA sequences in a sequence-specific manner.


Input: Teratospermia is therefore an important factor in evaluating fertilization capacity.


Input: Genomic DNA blot analysis indicates that the trout L2 locus has a cluster-like organization similar to the trout L1 locus and the IgL locus of several teleost fish.

trout L2 locus

trout L1 locus

IgL locus


Input: Genetic polymorphisms in the 5'-flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene.

human cytochrome P450IIE1 gene


Input: As exogenously expressed PKR can form heterodimers with endogenous PKR, the results obtained on the functional characterization of mutant forms of PKR have been taken with caution.

PKR

endogenous PKR

PKR


Input: Basal JNK MAPK kinase activity was also specifically induced by deltaEGFR, which correlated with increased phosphorylation of a 54-kDa JNK2 protein observed in deltaEGFR-containing cells.

JNK MAPK kinase

deltaEGFR

54-kDa JNK2 protein

deltaEGFR


Input: Isolation and properties of Drosophila melanogaster ferritin--molecular cloning of a cDNA that encodes one subunit, and localization of the gene on the third chromosome.

Drosophila melanogaster ferritin


Input: The single-copy U20 sequence is located on the same DNA strand as the nucleolin mRNA.

U20 sequence

nucleolin mRNA


Input: Maximum baroreceptor activity measured at 140 mm Hg and the slope of the pressure-activity curve were reduced in atherosclerotic (n = 15) compared with normal (n = 13) rabbits (425 +/-34 versus 721 +/-30 spikes per second and 6. 2 +/-0. 6 versus 10. 8 +/-0. 8 spikes per second per mm Hg, respectively, P <. 05).


Input: The effective use of superoxide dismutase from human erythrocytes in the late stages of experimental influenza infection

superoxide dismutase


Input: EMT was localized to chromosome 5q31-32, a region that contains the genes for several growth factors and receptors as well as early activation genes, particularly those involved in the hematopoietic system.

EMT


Input: However, neither SF-1 nor NGF-IB alone, binding as monomers, increases transcription.

NGF-IB


Input: Both purH and purD genes constitute a single operon and are coregulated in expression by purines as other purine genes are.

purH

purD genes

purine genes


Input: Fluorescence in situ hybridization was used to investigate the physical distribution and revealed that both retrotransposon families are present on all sugar beet chromosomes and largely excluded from chromosomal regions harbouring the 18S-5. 8S-25S rRNA genes.

5. 8S


Input: Application of the method using an 11-year microseismicity record revealed systematic spatial and temporal changes in the slip rate that were synchronous with earthquake activity and other independent measures of fault-zone slip.


Input: Furthermore, we have identified the major open reading frame (RF4; 2. 3 kb) as being essential for activation, and we have shown that the NF kappa B, SP1, and TATA box motifs in the human immunodeficiency virus LTR are all required for full induction of the promoter by the HHV-6-encoded transactivator.

NF kappa B

human immunodeficiency virus LTR

HHV-6-encoded transactivator


Input: Two conserved motifs, W89RKRRY94 and P156KKIKP161, seemed to act as nuclear addressing signals.


Input: All testosterone treatments raised plasma testosterone concentrations above control and pretreatment levels (testosterone and synovex + testosterone > synovex > control; all P < 0. 05).


Input: The educational program was the significant factor that influenced the change of concern trajectories, and the recurrent/non-recurrent factor influenced the change of concern only in pamphlet group.


Input: Biol.


Input: Snails infected with three or five miracidia produced more metacercariae than those infected with a single miracidium.


Input: Evidence that the AT1A receptor activates transcription factor-Stat91 and/or a related protein.

AT1A receptor

transcription factor-Stat91


Input: Two estimates of the fractal exponent are considered which do not suffer from this limit: one derived from the Allan variance, which was developed by the authors, and one based on the periodogram.


Input: The full-length cDNA was cloned and sequenced, and the inferred amino acid sequence was found to encode a novel protein, which we named cystatin M, with 40% homology to human family 2 cystatins and similar overall structure.

cystatin M

human family 2 cystatins


Input: Thus, oxyR mutants are locked on for Ag43 expression, whereas dam mutants are locked off for Ag43 expression.

oxyR mutants

dam mutants


Input: GH induced rapid tyrosine phosphorylation of a protein at approximately 93 kDa in normal fibroblasts, and Western blotting with STAT-specific antibodies revealed STAT5 activation (phosphorylation) by GH.

GH

STAT-specific antibodies


Input: The team physician and conditioning of athletes for sports: a consensus statement.


Input: Experimental exposure of poults with each of two strains representing the rarely reported capsular group B indicated that both were virulent.


Input: A drop of methylprednisolone acetate or vehicle constituent was placed on the dissected plantar nerve proximal to the stimulating electrodes after recording control responses (A-fibre volley in the sciatic nerve and C-fibre evoked reflex discharge in flexor motoneurons).


Input: Case of nephrotic syndrome caused by gold preparations


Input: Pax-6 constructs lacking the C-terminal activation domain repressed betaB1-crystallin promoter activity as effectively as the full-length protein, but the PD alone or Pax-6 (5a), a splice variant with an altered PD affecting its DNA binding specificity, did not.

betaB1-crystallin promoter

PD

Pax-6 (5a)

PD


Input: It is considered important, therefore, when treating diabetic patients with peripheral neuropathy not to assume that the diabetes itself is the cause in all cases.


Input: A retrospective study of clozapine and electroencephalographic abnormalities in schizophrenic patients.


Input: While working on the toxicity of war gases. he formulated' Haber' s rule', also known as C x T = constant in order to characterize the toxicity of an inhalant.


Input: Furthermore, the regulation conferred on a reporter gene in Drosophila by three closely related sequences demonstrates that even subtle sequence changes within an E box or flanking bases have dramatic consequences on the overall repertoire of proteins that can bind in vivo.


Input: The Sensititre MIC panels containing meropenem offer a convenient and valid alternative to the NCCLS reference method for the susceptibility testing of potential pathogens likely to be recovered from mixed infections.


Input: Two putative ATP-binding domains were identified, one in the amino-terminal half of the argA-encoded protein and the other in the carboxy-terminal half.

argA-encoded protein


Input: Previously, we identified two human SMC family proteins, hCAP-C and hCAP-E, which form a heterodimeric complex (hCAP-C-hCAP-E) in the cell.

human SMC family proteins

hCAP-C

hCAP-E

hCAP-C

hCAP-E


Input: There were no major postoperative complications and at follow-up of the 13 patients at 10 to 26 months after operation the results were satisfactory.


Input: The interleukin-2 receptor alpha (IL-2R alpha) chain gene contains a sequence similar to the immunoglobulin (Ig) kappa (kappa) enhancer NF-kappa B binding site.

interleukin-2 receptor alpha

IL-2R alpha

immunoglobulin (Ig) kappa

NF-kappa B binding site


Input: (1996) J.


Input: The presence of a short (70 bp) intron near the N-terminus of the atX gene was predicted that contains the canonical GT and AG dinucleotides at its 5'-and 3'-splicing junctions.

atX gene


Input: Studies on the reaction of cytochrome c with corticosteroids.

cytochrome c


Input: In accordance with Ann Arbor classification, we observed 12 CS IA (21. 3%), 2 CS IB (3. 5%), 14 CS IIA (25. 4%) and 27 CS IIB (49. 7%).


Input: The results can be summarized as follows.


Input: The level of expression of the PDE protein was monitored by immunoblot analysis using two specific cAMP-PDE polyclonal antibodies and by measuring the PDE activity.

PDE protein

cAMP-PDE polyclonal antibodies

PDE


Input: HL is hypothesized to directly couple HDL lipid metabolism to tissue/cellular lipid metabolism.

HL

HDL


Input: The analysis of the organization of the sequence of the human ABP/DAO gene reveals that the 2. 4-kilobase messenger RNA is transcribed from two close origins identifying the proximal promoter.

ABP

DAO


Input: Rottlerin also inhibited the activation of MAP kinase kinase (MEK) in response to activated Raf, but had no effect upon c-Raf activity or ERK activation by activated MEK.

MAP kinase kinase

MEK

Raf

c-Raf

ERK

MEK


Input: Especially if the number of dimensions of the samples is large, it can be said that BPN is better than k-NN in classification ability.


Input: Several DNA clones were obtained by this procedure, one of which, clone 18, is reported and characterized here.


Input: Immunoprecipitation of cell lysates with anti-phosphotyrosine and immunoblotting showed phosphorylated forms of the mitogenic pathway proteins Shc and MAPK in addition to p185 (neu), suggesting that the Ras to MAPK mitogenic pathway is activated.

anti-phosphotyrosine

Shc

MAPK

neu

Ras

MAPK


Input: The sequence immediately upstream of the translation start site was G + C rich (greater than 75%) and contained a consensus CCAAT sequence despite the absence of a TATA box.


Input: The development of various pathological lesions in thymus, spleen, lymph nodes and bone-marrow is frequently observed.


Input: RESULTS: After 3 weeks of therapy, the patient had an increase in platelet count from a baseline of 5, 000 to 8, 000/microliter to a maximal level of 33, 000/microliter.


Input: In the latter, the cells and adjacent matrix had several characteristics of fibrocartilage, including chondrocytes.


Input: Radiation sensitivity of rats irradiated in a condition of hypoxia


Input: When the opioid antagonist was administered to animals 24 hr after termination of single or multiple exposures to restraint, NALT-induced increases in basal plasma LH were significantly attenuated in the chronically stressed rats compared to animals subjected to stress only once or not at all. (ABSTRACT TRUNCATED AT 250 WORDS)

plasma LH


Input: Furthermore, CBP/p300 stimulated both TGF-beta-and Smad-induced transcription in a Smad4/DPC4-dependent fashion.

CBP

TGF-beta

Smad


Input: Analysis of exon 2 of the factor IX gene revealed a C--> T mutation in codon 10 of the propeptide region, resulting in the substitution of alanine by valine.

factor IX gene


Input: In contrast to the restricted tissue expression of gonadotropin and TSH receptors in gonads and thyroid, respectively, LGR4 is expressed in diverse tissues including ovary, testis, adrenal, placenta, thymus, spinal cord, and thyroid, whereas LGR5 is found in muscle, placenta, spinal cord, and brain.

gonadotropin

TSH receptors


Input: We now show that purified recombinant c-sis/PDGF can induce this binding activity which we have termed SIF, for sis-inducible factor.

c-sis

PDGF

SIF

sis-inducible factor


Input: Antinuclear antibodies, rheumatoid factor and C-reactive protein in serum of normal women using oral contraceptives.

rheumatoid factor

C-reactive protein


Input: We report here that AChE activity tends to decrease in individuals sampled in tanks at a salinity of 30 per thousand as temperature increases.

AChE


Input: The relationship between donor status for antibody to hepatitis B core antigen and the occurrence of non-A, non-B posttransfusion hepatitis in the recipient was prospectively studied in 112 patients undergoing open-heart surgery who were followed for 6. 5 months after surgery.

hepatitis B core antigen


Input: Both control and Mn-exposed quail accumulated 5 to 10 times more Mn in their livers than similarly treated rodents.


Input: These data suggested that mutant PS1 may cause disease as a result of reduction in PS1 function.

mutant PS1


Input: In response to phosphorus limitation, the fungus Neurospora crassa synthesizes a number of enzymes that function to bring more phosphate into the cell.


Input: IL-6 was detected in the urine of 52% of children with pyelonephritis compared with 15% of other children (P < 0. 001).


Input: The effects of pretreatment with the non-competitive NMDA antagonist (+) MK-801 on the behavioral alterations induced by repeated restraint stress were investigated.


Input: Radiation was delivered in a single 4-mJ pulse of 200 microseconds duration by means of an articulated zirconium fluoride optical fibre and a 320-microns quartz-fibre tip.


Input: MsEPV genes with putative functions in prevention and repair of DNA damage include a complete base excision repair pathway (uracil DNA glycosylase, AP endonuclease, DNA polymerase beta, and an NAD +-dependent DNA ligase), a photoreactivation repair pathway (cyclobutane pyrimidine dimer photolyase), a LINE-type reverse transcriptase, and a mutT homologue.

uracil DNA glycosylase

AP endonuclease

DNA polymerase beta

NAD +-dependent DNA ligase

cyclobutane pyrimidine dimer photolyase

LINE-type reverse transcriptase

mutT homologue


Input: In isolated olfactory cilia certain odorants elicit a rapid and transient cAMP response, terminated by a concerted process which requires the action of two protein kinases, protein kinase A (PKA) and a receptor-specific kinase (GRK3) (Schleicher, S., Boekhoff, I.

protein kinase A

PKA

receptor-specific kinase


Input: The results corroborate the proposed physiological function of CCoAOMT in elicited plant cells and may shed new light on the sequential action of trans-active factors in the regulation of phenylpropanoid genes.

CCoAOMT


Input: Two hundred and eighty-three patients, 217 females (median age 24 years, range 0. 5-73) and 66 males (median age 20 years, range 0. 75-72), were examined.


Input: Pneumatic dilation of the lower esophageal sphincter was accomplished by endoscopic visualization and positioning of a modified polyurethane dilator (90 F diameter) without fluoroscopy in 17 consecutive patients with advanced symptomatic achalasia.


Input: The organotins.


Input: A series of mutations were constructed within the E2 open reading frame which delete various regions of the conserved DNA binding and transactivation domains as well as the internal hinge region.


Input: These data indicate that chromatic processing in areas V1 and V2 is normal after V4 lesions and, together with the behavioural evidence, that these areas are sufficient for some basic aspects of colour perception.


Input: The Cryotherapy for Retinopathy of Prematurity Study has shown that this number can be halved with treatment.


Input: The non-major histocompatibility complex (MHC)-encoded CD1 family has recently emerged as a new antigen-presenting system that is distinct from either MHC class I or class II molecules.

non-major histocompatibility complex

MHC

CD1 family

MHC class I or class II molecules


Input: Nitroglycerin (glyceryl trinitrate) as a monoamine oxidase inhibitor.

monoamine oxidase


Input: Doxazosin produced increases in both mean and maximum urinary flow rates of 1. 01 ml/s and 3. 2 ml/s respectively, compared with 0. 21 ml/s and 2. 2 ml/s on placebo.


Input: We determined the complete nucleotide sequence of the gypsy element present at the forked locus of Drosophila melanogaster in the f1 allele.

gypsy element

forked locus


Input: Cloning and nucleotide sequence analysis reveals that BUR6 encodes a homolog of DRAP1 (also called NC2alpha), a mammalian repressor of basal transcription.


Input: The ATF/CRE site is also essential for CD4 promoter activation by forskolin, an activator of adenylate cyclase.

ATF

CD4 promoter

adenylate cyclase


Input: These results point towards post-translational steric and/or allosteric control of EKLF function that may be important not just for its DNA binding ability, but also for its potential to interact with other proteins that fully establish the correct stereospecific array leading to efficient switching of beta-globin transcription during development.

EKLF

beta-globin


Input: They are growth-inhibited by TGF-beta1.


Input: Chronic active hepatitis and cirrhosis of the liver.


Input: Colonization increased with level of care: from 9 per cent in independent residents of apartments to 60 per cent in patients on an acute hospital ward (P less than 0. 0001).


Input: Interaction of the v-rel protein with an NF-kappa B DNA binding site.

v-rel protein

NF-kappa B DNA binding site


Input: CVO2 saturation is a reliable and sensitive method for detecting blood loss.


Input: In the Saccharomyces cerevisiae actin intron a silent branch point-like sequence (UACUAAG) is located 7 nt upstream of the canonical sequence.

Saccharomyces cerevisiae actin intron


Input: The elevated levels of inositol phosphates resulting from N (epi) alpha qQ209L expression were similar to those obtained with carbachol activation of the M1 muscarinic acetylcholine receptor.

N (epi) alpha qQ209L

M1 muscarinic acetylcholine receptor


Input: To increase the number of circulating polymorphonuclear neutrophils, the patient was treated with recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) at a dose of 2 micrograms protein/kg bodyweight s. c./12 h.

granulocyte-macrophage colony-stimulating factor

GM-CSF


Input: PrRP rapidly and transiently activated extracellular signal-regulated protein kinase (ERK) in both types of cells.

PrRP

extracellular signal-regulated protein kinase

ERK


Input: Nevertheless, PEG influenced in vitro drug availability considerably, by increasing both drug solubility and dissolution rate.


Input: Reversible topology of a bifunctional transmembrane protein depends upon the charge balance around its transmembrane domain.


Input: We have documented previously that glucocorticoid hormones modulate the posttranslational localization of cell surface mouse mammary tumor virus (MMTV) glycoproteins in the viral-infected M1. 54 rat HTC hepatoma cell line.


Input: Contrast radiography appears to be an especially inaccurate method to document PUD in CF because the duodenal mucosa typically appears nodular and distorted with poor definition of the mucosal folds.


Input: Spodoptera frugiperda (Sf9) cells have proved a suitable cell system in which to study this association and to produce recombinant CR3, and we show here that another lepidopteran cell line, Trichoplusia niTN-5B1-4 (High-Five) cells, allows the recovery of large amounts of functional recombinant CR3.

recombinant CR3

functional recombinant CR3


Input: Using the standard scoring, children with full scale IQ < or = 84 on the Wechsler Preschool and Primary Scale of Intelligence at age 4-5 years were poorly identified (sensitivity 54%) from the composite S-B IV score at age 3.


Input: The relation between the changes of bone density and the level of blood calcium, blood phosphorus and alkaline phosphatase (AKP) as well as the metabolism of vitamin D was studied.

alkaline phosphatase

AKP


Input: To clarify the mechanisms that regulate transcription of the GTP cyclohydrolase I gene and to generate multiple species of mRNA, we isolated genomic DNA clones for the human and mouse GTP cyclohydrolase I genes.

GTP cyclohydrolase I gene

GTP cyclohydrolase I genes


Input: Perception of sweetness cannot be used to accurately meter the metabolizable energy or nutritive value of a food.


Input: These results suggest that termination is a highly specific event, and not merely a consequence of decreased stability of the EC.


Input: All sows nursed nine pigs.


Input: When labeled by the described method, 99mTc on DTPA coupled antibodies shows instability in serum but superior stability than 99mTc on antibodies without the attached DTPA.


Input: The crystal structure of the yeast Phe-tRNAPhe ternary complex with Thermus aquaticus EF-Tu-GDPNP (Phe-TC) has previously been determined as one representative of this general yet highly discriminating complex formation.

Phe-tRNAPhe ternary complex

EF-Tu

Phe-TC


Input: Our results indicate that GCN4 contains two activation domains of similar potency that can function independently to promote high-level transcription of the target genes HIS3 and HIS4.


Input: U. S. A.


Input: Human plastin genes.

Human plastin genes


Input: Role of the CCAAT/enhancer binding protein-alpha transcription factor in the glucocorticoid stimulation of p21waf1/cip1 gene promoter activity in growth-arrested rat hepatoma cells.

CCAAT/enhancer binding protein-alpha transcription factor


Input: We also demonstrate that a p110RB1 mutant, which is refractory to cell cycle phosphorylation but intact in E1a/large T antigen-binding properties, represses EIIaE with 50-to 80-fold greater efficiency than wild-type p110RB1.

p110RB1 mutant

large T antigen

EIIaE

wild-type p110RB1


Input: For the target stimuli, P3 amplitude and latency were negatively correlated and most tightly coupled over the frontal-central and right medial/lateral recording sites.


Input: We have characterized a new cDNA, 33k-6, potentially encoding a tobacco 33 kDa chloroplast RNP (cp33) homologue.

tobacco 33 kDa chloroplast RNP (cp33) homologue


Input: Though it has been established that skinfold anthropometry has severe limitations as a method of deriving total body fat (TBF), the possibility that the problem might be related more to the assumptions implicit in densitometry has to be addressed.


Input: Gene GPR 51 was localized by radiation hybrid mapping to chromosome 9, 4. 81 cR from the WI-8684 marker, and proximal to the hereditary sensory neuropathy type 1 locus.

Gene GPR 51

hereditary sensory neuropathy type 1 locus


Input: A) During O2-ischemia both extracellular [K +] and change of pH in the subepicardium are significantly less than in the midmyocardium.


Input: Some of these physiological responses are regulated via activation of transcription factors such as activator protein 1 (AP-1).

activator protein 1


Input: The 1. 6-kb cDNA (CBF-A) encoding 285 amino acids (aa) was obtained, and a beta-galactosidase fusion protein, bacterially produced from the cDNA, bound to DNA fragments containing several CArG boxes.

CBF-A

beta-galactosidase fusion protein


Input: Alveoli-capillary diffusion.


Input: The pattern of expression of this and other Chi26/Chi33 chimeric promoters suggest that the E-region contains cis-acting sequences which activate transcription in aleurone and silence transcription in leaves.

E-region


Input: Interobserver agreement of the Nottingham histologic grading scheme for infiltrating duct carcinoma breast.


Input: We have demonstrated that the specific determination and identification of plasma FbDP alone is not sufficient to follow the effectiveness of thrombolytic therapy.

FbDP


Input: To determine the role of the transmembrane region of HN on fusion-promoting activity, mutant HN proteins were expressed and their biological activities examined.

HN

mutant HN proteins


Input: Thus, transgene expression directed by both the human and mouse Rb promoters is restricted to a subset of tissues in which Rb is normally expressed during embryogenesis.

mouse Rb promoters

Rb


Input: The cDNA is predicted to encode a polypeptide of 298 amino acids that is homologous to the Y-box (inverted CCAAT) family of DNA-binding transcription factors.

Y-box (inverted CCAAT) family of DNA-binding transcription factors


Input: RAP has been shown to be a useful vaccine target site, and RIP and inhibitory AIPs as therapeutic molecules to prevent and suppress S. aureus infections.

RAP

RIP

AIPs


Input: First, mutations in the IFNgamma-activated sequence (GAS), either multimerized or in the context of the 1. 7-kb IRF-1 promoter, failed to mediate a PRL response, showing that the IRF-1 GAS is a target of PRL signaling.

IFNgamma-activated sequence

GAS

1. 7-kb IRF-1 promoter

PRL

IRF-1 GAS

PRL


Input: However, both RAR-and RXR-specific ligands increase CaSki number by > or = 20%.

RAR

RXR


Input: Tight-binding band structure calculations for beta-MNX (M = Zr, X = Cl, Br; M = Hf, X = Cl), ZrCl, and Y (2) C (2) Br (2) are reported.


Input: The same high degree of sequence homology between the two F. diplosiphon PC alpha and PC beta sequences (85 and 77%, respectively) was found at both the nucleotide and amino acid levels, and similar results were obtained for interspecies comparisons.

PC alpha

PC beta sequences


Input: Interestingly, the expression of Id4 in Sertoli cells is only detectable after stimulation with FSH or cAMP.

FSH


Input: On the basis of the physical interactions between Sxl and Snf, we present a model for Sxl splicing regulation.

Sxl

Snf

Sxl


Input: It thus seems likely that genistein affects a common pathway downstream of these signals.


Input: LiF thermoluminescence dosimeters (TLD) in chip form were placed onto 1 eyelid, the skin over the thyroid, and the patient' s clothes covering the region of breasts and ovaries of female patients and the testicles of male patients.


Input: Several positive clones were isolated, one of which encoded the C-terminal 253 amino acids of a putative RNA helicase, a DEAD box protein designated DDX3.

RNA helicase

DEAD box protein


Input: The related tumor suppressor, p130, also effects this function. p107 levels increase substantially as cells progress through S phase. p107 induction of E2F DNA binding was observed primarily in S phase cells coincident with the increase in p107 protein levels.

p107 protein


Input: We conclude from these observations that the cTnC 3' Ile element is a composite enhancer that functions through the combined interactions of at least five regulatory elements and their cognate binding factors: three or four E-boxes, a MEF-2 site, and a MEF-3 site.

cTnC 3' Ile element

MEF-2 site

MEF-3 site


Input: These data suggest that the secreted, truncated receptor encoded by the 2. 6-kb c-erbB transcript can bind to TGF alpha and may play an important growth-regulatory function in vitro.

2. 6-kb c-erbB transcript

TGF alpha


Input: In this paper we review evidence on smoking and lung cancer among Latinos, including findings from several unpublished studies and technical reports.


Input: Although several large waterborne outbreaks occurred during the past decade, most were in small communities.


Input: Many of the metabolic effects induced by thiazide diuretics, however, can be limited by the use of low doses.


Input: Uptake of colicins required different domains in TonB, for colicin B and M around residue 160 and for colicin Ia, a domain closer to the C-terminal end.

colicins

TonB

colicin B and M

colicin Ia


Input: A phase II study of interferon-alpha, interleukin-2 and 5-fluorouracil in advanced renal carcinoma: clinical data and laboratory evidence of protease activation.

interferon-alpha


Input: Three putative ORFs have significant homology with known proteins: L0968 is a new member of the very large' seripauperins' family, comprising at least 20 yeast members; L1313 is a new ABC transporter highly homologous to the yeast cadmium resistance protein Ycf1p and to the human multidrug resistance protein hMRP1; the C-terminal part of L1325 present in our sequence is very homologous to the fruit fly abdominal segment formation protein Pumilio.

' seripauperins'

ABC transporter

human multidrug resistance protein hMRP1

Pumilio


Input: Previously, we reported the identification of a 23-kD protein that interacts with zyxin in vitro (Sadler et al., 1992).

zyxin


Input: Most significantly, the cyclin E-Cdk2 complex is maximally active at the G1/S transition, and overexpression of cyclin E decreases the time it takes the cell to complete G1 and enter S phase.

cyclin E

cyclin E


Input: In this report, we demonstrate that FRS2 forms a complex with the N-terminal SH2 domain of the protein tyrosine phosphatase Shp2 in response to FGF stimulation.

N-terminal SH2 domain

protein tyrosine phosphatase Shp2

FGF


Input: In static conditions, body sway was assessed using a conventional force platform with eyes open and with eyes closed.


Input: Antiserum raised against rat liver S6 kinase specifically immunoprecipitates the purified 32P-labeled H4 hepatoma insulin-stimulated S6 kinase.

rat liver S6 kinase

S6 kinase


Input: In vitro, SHIP catalyzes the conversion of the phosphoinositide 3-kinase (PI3K) product phosphatidylinositol 3, 4, 5-trisphosphate (PIP3) into phosphatidylinositol 3, 4-bisphosphate.

SHIP

phosphoinositide 3-kinase


Input: A species comparison of cDNA sequences and isolation of a genomic clone.


Input: The study of the intensity of pain evoked by heat is relatively exhaustive: the influence of various local, stimulus-dependent or general factors upon threshold values has been well studied, as has the relation between pain and stimulus intensities.


Input: However, they had no cross-resistance to quinolone, josamycin and tylosin.


Input: A search was conducted for suppressors of the inositol auxotrophic phenotype of the ino4-8 mutant of yeast.

ino4-8 mutant


Input: Diabetic osteopathy.


Input: A simple technique for obtaining ultra-thin sections of coccidian oocysts is reported.


Input: These data, taken together, suggest that CRF produces its behavioral activating and anxiogenic effects, at least in part, by increasing the activity of LC noradrenergic neurons.

CRF


Input: Moyamoya is an intriguing and controversial syndrome.


Input: An ethnic analysis was made of 8947 cases of primary central nervous system (CNS) tumors seen at the Armed Forces Institute of Pathology (AFIP), Washington, DC, from 1971 to 1985.


Input: SN-38 rebound concentrations were observed in many courses at about 0. 5 to 1 hour following the end of the i. v. infusion, which is suggestive of enterohepatic recycling.


Input: Kondo effect in Cu (Fe) films.


Input: The S3 protein also contains a DNA repair activity, efficiently processing 8-oxoguanine residues in DNA via an N-glycosylase/apurinic-apyrimidinic (AP) lyase activity.

S3 protein

N-glycosylase

apurinic-apyrimidinic (AP) lyase


Input: The orf2 gene product is a protein of 79 amino acids with characteristics similar to those of the Tat (transactivator) proteins of the ungulate lentiviruses.

Tat

transactivator


Input: This paper describes a longitudinal study in which clinical parameters and aspartate aminotransferase (AST) in gingival crevicular fluid (GCF) were monitored bimonthly over a 6-12 months period in 970 sites from 7 treated periodontitis patients.

aspartate aminotransferase

AST


Input: Our results show that unlike the case for sos1, sos2 gene function is dispensable for normal mouse development, growth, and fertility.

sos2 gene


Input: This finding is of importance because it completes an explanation for central near-location errors in the partial-report bar-probe task.


Input: Patients were treated with either 4. 8 million units of procaine penicillin with 1 g probenecid, 3. 5 or 4. 5 g of ampicillin with 1 g probenecid, or 9. 5 g of tetracycline given over 4 days.


Input: Here, we analyzed the interaction of the Lactococcus lactis Ll. LtrB group II intron endonuclease with its DNA target site by DNA footprinting and modification-interference approaches.

Lactococcus lactis Ll. LtrB group II intron endonuclease


Input: Treatment of JEA2 cells with interleukin (IL)-7 induces CBLB phosphorylation as well.

interleukin (IL)-7

CBLB


Input: Plasmid pNK21, in which 2. 05-kb sequence covering the region encoding the nitrilase was was placed under the control of the lac promoter, directed overproduction of enzymatically active nitrilase in response to addition of isopropyl beta-D-thiogalactopyranoside in Escherichia coli.

nitrilase

lac promoter

enzymatically active nitrilase


Input: Penicillamine-induced myasthenia gravis associated with antibodies to acetylcholine receptor.

acetylcholine receptor


Input: UV cross-linking and Southwestern analysis suggested that KTP1 is a DNA-binding protein clearly distinct from AP2, and this protein may be responsible for the basal keratinocyte-specific expression of the BPAG1 gene.

BPAG1 gene


Input: In frozen sections the spots appear as blue labelled neurones with a light microscope, or as a brilliant red neurones surrounded by reddish tissue with a fluorescence microscope.


Input: CONCLUSIONS: Elevation of TBARS and decrease of GSH show the presence of oxidative stress during the PFD treatment with hemodiafilter SG3.


Input: Like the DMA, but unlike all other mammalian class II A genes, the zebrafish gene codes for two cysteine residues which might potentially be involved in the formation of a disulfide bond in the alpha 1 domain.

DMA

mammalian class II A genes


Input: For any given age, high-stressed plantaris tendons were of a higher fatigue quality than low-stressed extensor tendons.


Input: A mutated ABF1 site that displays a very low affinity for ABF1 does not functionally replace the ILV1 REB1 site.

mutated ABF1 site

ILV1 REB1 site


Input: It is of interest that, aside from starvation, the nutrition catastrophes of the past, including scurvy (vitamin C deficiency) resulting from lack of fresh vegetables and fruit and beriberi (vitamin B1 deficiency) from consumption of polished rice, are forgotten and only of interest as history.


Input: In contrast, overexpression of the DREB2A cDNA induced weak expression of the target genes under unstressed conditions and caused growth retardation of the transgenic plants.

DREB2A cDNA


Input: In vitro, c-Src phosphorylated FAK Tyr-925 in a glutathione S-transferase-FAK C-terminal domain fusion protein, whereas FAK did not.

c-Src

FAK Tyr-925

glutathione S-transferase

FAK


Input: The aetiology and management of diabetic impotence is well-documented; the effects of diabetes on female sexuality are not so clear.


Input: The percentage distribution of types of fixation disparity curves was found to be similar to some previous studies, with a higher prevalence of Type I curve (64. 3%), followed by Type II (28. 6%) and Type III (7. 1%) curves.


Input: 1. 23) as a PPARalpha-interacting protein.

PPARalpha-interacting protein


Input: Reading disability in twins.


Input: Analysis of the 5' and 3' termini of the transcripts produced in vivo from the puf operon of R. sphaeroides PUF delta 348-420 (three transcripts; 0. 59, 0. 64, and 2. 63 kilobases) lacking the puf-intercistronic terminator structure were identical to those of the corresponding puf transcripts derived from wild-type R. sphaeroides 2. 4. 1 (four transcripts; 0. 50, 0. 66, 0. 71, and 2. 7 kilobases) showing that the transcripts begin and end at the same sites.

puf operon of R. sphaeroides PUF delta 348-420

puf transcripts


Input: The mean amount of blood loss prior to time of injection was 4. 5 units (a range of 3 to 10 units).


Input: Several of the drugs used in the management of MAC have been associated with significant drug interactions involving the cytochrome P450 (CYP) enzyme system.

cytochrome P450

CYP


Input: Therapy and prevention of irreversible shock with pharmacological doses of some corticosteroids


Input: Suppression of the cka1 delta cka2-8 mutant phenotype occurs by interaction of CKB1 with the defective, cka2-8-encoded, catalytic subunit.

cka1 delta cka2-8 mutant


Input: Historically, Cyps were first identified by their ability to bind the immunosuppressive agent cyclosporin A (CsA) with high affinity; they later were found to have peptidyl-prolyl cis-trans isomerase (PPIase) activity, which catalyzes the folding of oligopeptides at proline-peptide bonds in vitro and may be important for protein folding in vivo.

Cyps

peptidyl-prolyl cis-trans isomerase

PPIase


Input: Reduced glutathione in whole blood decreases within a blood Se range of 1. 01 to 2. 28 micrograms in the high Se area.


Input: Promoter elements and transcriptional control of the mouse acetylcholinesterase gene.

mouse acetylcholinesterase gene


Input: To our knowledge 108 cases of EAT treated by catheter ablation of the ectopic focus are reported in the literature with a success rate superior to 90%.


Input: The authors report two cases of orbital cavernous hemangioma diagnosed by Tc-99m RBC SPECT.


Input: 250, 302-311].


Input: Arterial compliance measurements using intraarterial pulse contour analysis and a modified Windkessel model were carried out in 19 patients with isolated systolic hypertension (> or = 160/< or = 90 mm Hg) and compared to measurements in 29 patients with essential hypertension (diastolic blood pressure [BP] > or = 95 mm Hg) and 47 normotensive control subjects.


Input: The relationship between CSF somatostatin and peripheral thyroid hormones was assessed in 11 affectively ill patients before and during carbamazepine treatment.

CSF somatostatin