Input: Heart rate during the behavioral avoidance test was shown to be as susceptible to experimental demand as other studies have shown approach behaviors to be influenced.


Input: In addition, we mapped a putative hnRNP A1 binding site in U5 RNA and demonstrated that p40CRS (hnRNP A1) binding to that site correlates with CRS function.

hnRNP A1 binding site

U5 RNA

hnRNP A1

CRS


Input: Biochemical experiments and genome sequencing have shown that, despite the prokaryotic cell and genome organization, basal transcriptional elements of members of the domain Archaea (i. e., TATA box-like sequences, RNA polymerase, and transcription factors TBP, TFIIB, and TFIIS) are of the eukaryotic type.

RNA polymerase

TBP

TFIIB

TFIIS


Input: MGF is a novel member of the cytokine-regulated transcription factor gene family.

MGF

cytokine-regulated transcription factor gene family


Input: One month after administration of 131I, the 29 cats evaluated were clinically improved, and 24 (83%) of the 29 cats evaluated had normal serum T4 concentrations, 3 cats (10%) remained hyperthyroxinemic, and 2 cats (7%) were hypothyroxinemic.


Input: Csk (C-terminal Src kinase) is a protein tyrosine kinase that phosphorylates Src family member C-terminal tails, resulting in downregulation of Src family members.

Csk

C-terminal Src kinase

protein tyrosine kinase

Src family member C-terminal tails

Src


Input: Northern blot analysis of enoyl-ACP reductase mRNA steady-state levels during seed development suggests that the increase in enzyme activity during the phase of storage lipid accumulation is regulated at the level of gene expression.

enoyl-ACP reductase mRNA


Input: Lung transplantation is warranted for stable, ventilator-dependent recipients.


Input: A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes.

myocyte-specific enhancer-binding factor


Input: The magnesium content in leukocytes could not be estimated because of interaction between the ion and the Percoll (R) media.


Input: The need for such guidelines is clear on both clinical and scientific grounds.


Input: This activity creates a 4-bp staggered cut with 3' OH overhangs within a specific sequence of the 21S rRNA gene of omega-strains.

21S rRNA gene


Input: Herewith C. psittaci could be diagnosed in all positive samples.


Input: Chem.


Input: The gene responsible for multiple endocrine neoplasia type 1 (MEN1), a heritable predisposition to endocrine tumours in man, has recently been identified.


Input: Is it time for a wine trial?


Input: We previously identified a highly conserved L-X-X-L-F sequence near the C terminus of the p6 domain of the Gag precursor as the major virion association motif for HIV-1 Vpr.

p6 domain

Gag precursor

HIV-1 Vpr


Input: Three patients treated with amphotericin B, single course as well as multiple courses, and other antifungal agents (hydroxystilbamidine and miconazole) have all relapsed.


Input: The site of acetylation of Tat was mapped to the double-lysine motif in a highly conserved region, (49) RKKRRQ (54), of the basic RNA-binding motif of Tat.

Tat

Tat


Input: In contrast to Torpedo, where only a single transcript is seen, the mouse expresses several mRNAs encoding different isoforms.


Input: trans-activation of the HIV-1 LTR by the HIV-1 Tat and HTLV-I Tax proteins is mediated by different cis-acting sequences.

HIV-1 LTR

HIV-1 Tat

HTLV-I Tax proteins


Input: NSD1 contains a SET domain and multiple PHD fingers.

SET domain


Input: After 1 day, none of the labeled erythrocytes were detected.


Input: Latex products (gloves, balloons, and condoms) directly bound IgE from all four patients.

IgE


Input: The results indicate that the RNA in T7 RNA polymerase is not free of steric interactions in the ternary complex and not available for structure formation until it is at least 10 bases away from the site of polymerization.

T7 RNA polymerase


Input: Effect of infantile undernutrition on adult sucrose solution consumption in the rat.


Input: The transcriptional activity of P-450 (11 beta) gene was studied with an in vitro transcription system using nuclear extracts prepared from bovine adrenal cortex.

P-450 (11 beta) gene


Input: The analysis showed that the morning active (MA) individuals rose earlier and went to bed earlier than the evening active (EA) individuals, and the former had a longer sleep length than the latter during days with a morning shift, while the opposite was true for afternoon and night shifts.


Input: Appl.


Input: The CHED protein includes the consensus ATP binding and phosphorylation domains characteristic of kinases, displays 34-42% identically aligned amino acid residues with other cdc2-related kinases, and is considerably longer at its amino and carboxyl termini.

CHED protein

cdc2-related kinases


Input: These include urinalysis, chest X-P, ECG, hematological examinations (RBC, WBC, Ht, Hb, PLT and ESR) and biochemical tests (AST, ALT, ALP, gamma GTP, LDH, CPK, Chol, T-Bil, TP, Alb, TG, BUN, Cr, Glu, Na, K, Ca, P and CRP).

Hb

AST

ALT

ALP

gamma GTP

LDH

CPK

Alb

CRP


Input: We challenge each of 55 consecutive ragweed (RW)-allergic patients with hay fever and with graded increasing doses of ragweed extract to investigate the frequency and relationship between the early (ER), late (LPR), and rechallenge reactions (RCRs) to nasal challenge.


Input: Vasodilator and hypotensive effects of the optical isomers of nicardipine (YC-93), a new Ca2 +-antagonist.


Input: The encoded protein contains an amino terminal PDZ domain, followed by a predicted coiled-coil region, a PEST domain, and a carboxy-terminal SAM domain.

PDZ


Input: The 5' ends of the P and O gene mRNAs are separated by 109 nucleotide pairs in the DNA template.

P

O gene mRNAs


Input: Those diagnosed as having affective disorder (n = 96), according to DSM-IIIR criteria, were compared with the other non-affective suicide attempters (n = 161).


Input: The leukotriene receptor antagonist zafirlukast inhibits sulfur dioxide-induced bronchoconstriction in patients with asthma.

leukotriene receptor


Input: The p63 sequence also features an acidic domain characteristic of transcriptional activation factors, as well as sequence blocks displaying limited similarity to positionally equivalent regions in sigma factors from eubacteria related to mitochondria.

p63 sequence

sigma factors


Input: We have thus cloned two yeast homologs of mammalian p220.

mammalian p220


Input: A phase II clinical trial on MDS was conducted in a cooperative study with orally administrable ara-C analogue, PLAC, which is resistant to cytidine deaminase and had shown an anti-tumor activity on various experimental tumors by oral route.

cytidine deaminase


Input: The arrangement of amino acids in the helix 1 and helix 2 regions is quite similar to those of Mxi and Mad, but different from those of E2F-1 and DP-1.

Mxi

Mad


Input: Platelets and RBCs from each animal were labeled with 51Cr and 99mTc, respectively, and were rapidly injected into the right atrium while blood was sampled from the ascending aorta.


Input: PDGF stimulated CDK2 activity in mesangial cells and decreased the level of p27 (kip1) cyclin kinase inhibitor protein.

PDGF


Input: Furthermore, the induction of cytochrome P-450 1A1 observed in the cormorant indicates that the Ah receptor-mediated process, by which TCDD and related chemicals exert many of their toxicities, has been activated.

cytochrome P-450 1A1

Ah receptor


Input: In gel mobility shift assays, high binding activities of ATPC-2 and low binding activities of CBF were observed with nuclear extracts from tissue with low AtpC expression levels, and the opposite was observed with extracts from tissues with high AtpC expression levels.

CBF

AtpC

AtpC


Input: A case of bilateral testicular germ cell tumors in a 23-year-old male is reported.


Input: Using green fluorescent protein fusions we demonstrate that the SYT, SSX and the SYT-SSX proteins are nuclear proteins.

green fluorescent protein

SYT

SSX

SYT

SSX


Input: Thus, the mutants are deficient in production of the O-antigen polymerase and were termed rfc mutants.

O-antigen polymerase

rfc mutants


Input: The program for myogenic differentiation is subject to negative control by several peptide growth factors and by the products of mutationally activated ras oncogenes, which persistently activate intracellular cascades normally triggered by specific growth factors.

ras oncogenes


Input: The p58 (PITSLRE beta 1) protein kinase (PK) is a member of a large supergene family related to the master mitotic protein kinase, p34cdc2.

PITSLRE beta 1

master mitotic protein kinase


Input: By a combination of alternative promoter usage and exon splicing, each ROR gene generates several isoforms that differ only in their amino terminus.

ROR gene


Input: The expression pattern of LjEmx changed dramatically during embryogenesis; expression was seen initially in the entire neural tube and mesoderm, which were secondarily downregulated, and secondarily in cranial nerve ganglia and in the craniofacial mesenchyme.

LjEmx


Input: Similarly, antisense TGF-beta type II receptor oligodeoxynucleotides (40 microM) resulted in a 58% increase in branching, compared to scrambled and mismatched sequence controls, while TGF-beta, type II receptor mRNA and its protein expression levels were suppressed by 95 and 84%, respectively.

antisense TGF-beta type II receptor oligodeoxynucleotides (40 microM)

TGF-beta, type II receptor mRNA


Input: Despite this loss, YEpFAS1 is still able to complement a fas1 mutation at the enoyl reductase domain.

enoyl reductase


Input: In this study, a site of PDGF-induced tyrosine phosphorylation was mapped to Tyr 138 in the SH3 domain; Tyr 138 is exposed on the SH3 peptide binding surface.

PDGF

SH3 domain

SH3 peptide binding surface


Input: Our results showed that the 5-hydroxytryptamine (5-HT) content in platelets was: (1) increased in the subgroup of anti-social alcoholics; (2) transiently and differently altered in alcoholics compared to opiate addicts; and (3) lowered in drinking alcoholics and normal in alcoholics who were drinking as well as smoking (that may occur via MAO-B inhibition by smoke).

MAO-B


Input: Recently, we reported that SMRT also directly associates with LAZ3 (BCL-6), a POZ/Zn finger transcriptional repressor involvedin the pathogenesis of non-Hodgkin lymphomas.

SMRT


Input: Regulation of activating transcription factor-1 and the cAMP response element-binding protein by Ca2 +/calmodulin-dependent protein kinases type I, II, and IV.

activating transcription factor-1

cAMP response element-binding protein

Ca2 +/calmodulin-dependent protein kinases type I, II, and IV


Input: Accordingly, constitutive downregulation of expression of accessory molecules of the MHC class I pathway can reveal differences between H2 class I alleles in antigen presentation not encountered when the expression levels are augmented.

MHC class I pathway

H2 class I alleles


Input: Cross-sectional studies continue to dominate.


Input: G6620 is the 3' end of the MOL1 gene coding for a polypeptide similar to stress-inducible proteins from Fusarium; G6630 is the NAT2 gene which encodes a methionine N-acetyltransferase; G6635 is the RPL30B gene coding for the ribosomal protein L30; G6658 is RSR1 encoding a ras-related protein; G6667 is CYS4, the gene for cystathionine beta-synthase; G6670 is identical to ORF2 located close to CYS4; G6673 is PEM1/CHO2 encoding a phosphatidylethanolamine methyltransferase; G7001 is the NSR1 gene coding for a nuclear signal recognition protein.

MOL1 gene

NAT2 gene

methionine N-acetyltransferase

RPL30B gene

ribosomal protein L30

ras-related protein

cystathionine beta-synthase

phosphatidylethanolamine methyltransferase

NSR1 gene


Input: The tau v at rest was 4. 06 +/-2. 16 s and decreased to 2. 44 +/-1. 07 s (P < 0. 05) at 1 Hz and to 1. 81 +/-0. 4 s at 5 Hz.


Input: This action could be antagonized by aminophylline, a competitive antagonist on P1 purinoceptors.

P1 purinoceptors


Input: In the predicted amino acid sequence of NPS1, sequences homologous to the catalytic domain of protein kinases were found.


Input: The cDNA contains a reading frame for a 145-amino-acid protein and it lacks the UGA codons, which have been found in the reading frame of the mouse MCS cDNA and have been presumed to encode the selenocysteine in the amino terminal of the deduced mouse amino acid sequence.

mouse MCS cDNA


Input: It differed significantly by country (from 2. 4% in the United Kingdom to 24. 7% in Portugal) and by transmission category (2. 7% among homo/bisexuals, 5. 8% among injecting drug users, 13. 6% among heterosexual subgroup 1).


Input: A definition of bias founded on the concept of the study base.


Input: The results showed differential activation of each parahippocampal region during verbal memory tasks in which the side activated shifted depending on the nature of the task employed; an increase in rCBF in the left parahippocampal gyrus was associated with retrieval strategy of non-matching, and an increase in rCBF in the right parahippocampal gyrus was associated with retrieval strategy of matching.


Input: Cells were co-infected simultaneously with IBV, the recombinant FPV (rFPV) containing the D-RNA sequence and a second rFPV expressing T7 RNA polymerase for the initial expression of the D-RNA transcript, subsequently rescued by helper IBV.

T7 RNA polymerase


Input: Antigen dose-response curves were drawn, and the cumulative dose required for a 35% reduction in specific airway conductance was calculated and designated Provocation Dose (PD35).


Input: The use of the two pharmacokinetic parameters, t1/2 and Cltp, as indices of drug elimination ability are discussed.


Input: The rapid decrease of plasma potassium during the first two hours of standard HD causes a membrane hyperpolarization.


Input: The more sustained effect of cyclofenil on prolactin secretion with a reduced frequency of relapse, and the lower oestradiol level, which might indicate a reduced risk of thromboembolism, suggest that this drug has some advantage over bromocriptine in the inhibition of postpartum lactation.

prolactin


Input: Therefore prostaglandin E2 is characterized in relation to prostaglandin F2-alpha not only by a stronger uterine effectiveness, but also at the same time a pronounced influence on the cardiovascular system.


Input: Epithelial cell-specific activation is achieved by the cooperative interaction of apparently ubiquitous transcriptional factors.


Input: This set of genetic and physical interactions suggests a role for yeast RNA-binding proteins in transcriptional regulation.


Input: In group 1, mean z-score for GFR was-0. 27 (94. 6% of normal) and in group 2 mean z-score was-1. 51 (72. 7% of normal for two kidneys) (P = 0. 022, Mann-Whitney U-test).


Input: A new B-cell-specific enhancer element has been identified 3' of E4 and the octamerlike motifs in the human immunoglobulin heavy-chain gene enhancer.

human immunoglobulin heavy-chain gene enhancer


Input: The mutants retained the parental ability to participate in intergeneric coaggregation with human oral actinomyces, indicating the specificity of the mutation in altering intrageneric coaggregations.


Input: Electrically induced undulations and their competition with electrically induced convection in cholesteric liquid crystals.


Input: Critical review of general results


Input: A visibly distinct muscular hypertrophy (mh), commonly known as double muscling, occurs with high frequency in the Belgian Blue and Piedmontese cattle breeds.


Input: The LS gene promoter sequence has homology with Escherichia coli promoter sequences; its terminator sequence is capable of forming a stem-and-loop structure.

LS gene promoter sequence


Input: The apparent binding constant of 6 to calf thymus DNA is 1. 68 X 10 (5) M-1 whereas netropsin under similar conditions gives a value of 1. 85 X 10 (7) M-1.

netropsin


Input: Computed tomographic (CT) findings of pancreatic ductal adenocarcinoma were studied with the combined method of early enhancement CT and high dose enhancement CT in 72 carcinomas.


Input: Southern hybridization analysis of BenR and BenS transformants suggested that plasmid integration occurred most frequently at the chromosomal bens locus, however evidence for gene conversion and heterologous recombination was also observed.

BenR

BenS transformants

bens locus


Input: Recombinant mouse GSTT1-1 was catalytically active towards 1, 2-epoxy-3-(p-nitrophenoxy) propane, 4-nitrobenzyl chloride and dichloromethane.

Recombinant mouse GSTT1-1


Input: The amount of overlap in VFI, EF, and RVF values among the clinical groups was considerable.


Input: In pituitary GH3 cells, vitamin D increases the levels of PRL transcripts and stimulates the PRL promoter.

PRL transcripts

PRL promoter


Input: Neonatal masculinization affects maternal behavior sensitivity in female rats.


Input: The Thrombolysis in Myocardial Infarction (TIMI) Phase II Trial randomized 3, 339 patients to either an invasive (INV, n = 1, 681) or a conservative (CON, n = 1, 658) strategy after intravenous recombinant tissue-type plasminogen activator (rt-PA) for acute myocardial infarction.

recombinant tissue-type plasminogen activator

rt-PA


Input: Present investigation was undertaken to elucidate what pharmacokinetic parameters in animal experiment could be of more predictable for human clinical trial of beta-blocking agents.


Input: Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways.

Smads

lymphoid enhancer binding factor 1

T cell-specific factor

transforming growth factor-beta

wnt


Input: In the univariate models of either fixed or time dependent covariates, many variables were significantly associated with risk of progression to AIDS (T4 cell count, T4/T8 ratio, blastogenic responses to phytohemagglutinin, concanavalin A, and pokeweed mitogen, serum IgA, appearance of p24 antigen, and the development of oral hairy leukoplakia, thrush, or herpes zoster).

phytohemagglutinin

concanavalin A

pokeweed mitogen

serum IgA

p24 antigen


Input: But, when mated males built nests in the absence of young, T levels were higher than in all other conditions, though only for early broods.


Input: RESULTS: At short dwell times, uncorrected (whole plasma) D/P and Cp of urea values were higher than the corrected (plasma water) values by 5. 7%-5. 9%.


Input: However, there are some cows that fail to produce adequate 1, 25-dihydroxyvitamin D at the onset of lactation.


Input: The AmyI specific 3'-UTR is characterized by the absence of IR sequences and the presence of a putative' AATAAA' polyadenylation signal.

AmyI


Input: Off-shell effect in Rydberg-atom-alkali-metal-atom scattering.


Input: We examined the mechanisms by which two different types of photonic radiation, short wavelength UV (UV-C) and gamma radiation, activate transcription factor NF-kappaB.

NF-kappaB


Input: To examine the biochemical mechanism of Tax1 transactivation, we have developed an in vitro transactivation assay in which wild-type Tax1 is able to specifically transactivate a polymerase II promoter through upstream Tax1-responsive elements.

polymerase II

Tax1-responsive elements


Input: The atf1 + gene of Schizosaccharomyces pombe encodes a bZIP transcription factor with strong homology to the mammalian factor ATF-2.

atf1 + gene of Schizosaccharomyces pombe

bZIP transcription factor

mammalian factor ATF-2


Input: Cotransfection experiments revealed that both hGATA-4 and PMA/A23187 stimulation are necessary for the IL-5 promoter activation.

IL-5 promoter


Input: Prenatal diagnosis of genetic diseases.


Input: Mortality rates were not different (chi2: 0. 0298, p > 0. 5).


Input: M., Apps, D.


Input: Cox proportional hazard analysis identified dialysis modality and pre-dialysis UV of less than 1, 000 ml/m2 per 24 h as the only significant risk factors for UV survival.


Input: The sequence of the 25-kDa chain of the alpha subunit was found in a cDNA clone, and the amino acid sequence deduced from the cDNA establishes the complete amino acid sequence of the 25-kDa chain.


Input: The Gastrointestinal Tumor Study Group (GITSG) protocol GI-7175 randomized 227 patients between 1975 and 1980 following complete surgical resection of stages B2 and C rectal adenocarcinoma to four treatment arms: (1) no adjuvant therapy, (2) chemotherapy only, (3) radiotherapy only, and (4) radiotherapy and chemotherapy (combined modality).


Input: Samples (1 g) were extracted with 0. 5% potassium chloride (KCl) in 70% methanol (5 ml) and diluted subsequently to give two-fold to ten-fold step-wise dilutions in phosphate-buffered saline containing 0. 05% Tween 20 and 0. 2% bovine serum albumin (PBS-T BSA).

bovine serum albumin

BSA


Input: A total of 4, 916 children were examined and the questionnaire satisfactorily completed by a relative or guardian (usually the mother) of 4, 651.


Input: Using community development approaches.


Input: Cell lines expressing single amino acid substitutions of the carboxyl-terminal asparagine of CD2 are incapable of avidity regulation by TCR signaling, PMA treatment, or elevation of intracellular cAMP levels, demonstrating that each of these stimuli utilizes a common structural element for regulating CD2 avidity.

TCR


Input: Iomazenil-SPECT revealed a highly significant increase in the benzodiazepine receptor uptake in all studied cortical regions except temporal cortices.

benzodiazepine receptor


Input: These findings suggest that PGE1 is effective in increasing PVF in the liver transplanted condition; however, the hepatic circulatory improvement attributed to this agent would be limited to the first few days following transplantation.


Input: However, in a variation of this assay in which the protease is omitted, the mutant enzymes exhibited substantial levels of prolyl isomerase activity (5-20% of wild-type), revealing that these mutations confer sensitivity to protease digestion and that the classic in vitro assay for prolyl isomerase activity may be misleading.

prolyl isomerase

prolyl isomerase


Input: The WEB2 gene encodes a 1, 522-amino-acid protein with homology to nucleic acid-dependent ATPases.

WEB2 gene

nucleic acid-dependent ATPases


Input: V-ErbB-mediated complex formation and transformation have been shown to occur independently of Ras activation.

V-ErbB-mediated complex

Ras


Input: The three OAS genes are flanked by markers WI-10614 (cen) and D12S2293 (tel) and are contained within three sets of overlapping cosmid clones.

OAS genes

markers WI-10614

cen

tel


Input: 5'-Deletion of the Stat-binding sites abolished all promoter-reporter activity in response to PRL.

Stat-binding sites

PRL


Input: Increasing the height of the agar column overlying the SN fabric diminished the inhibitory effect of SN on microbial growth.


Input: However, differential utilization of these determinants mediate RAR-RXR heterodimer binding to DR-2 and DR-5 RAREs.

RAR

RXR


Input: Biochem.


Input: Conversely, as a GAL-4 chimera, the isolated LAZ3/BCL6 BTB/POZ domain appears nearly as efficient as the entire protein at inducing transcriptional repression.

GAL-4 chimera

BCL6 BTB


Input: When expressed in Escherichia coli, SH-PTP2 displays tyrosine-specific phosphatase activity.

tyrosine-specific phosphatase


Input: It is hypothesized this occurs through antagonism of PML/RAR alpha actions in these leukemic cells.

PML

RAR alpha


Input: The main new features of this version are that end-tidal PO2 instead of inspiratory PO2 can be kept constant, and that the correcting activity of both controllers (capnostat and oxystat) is proportional to the magnitude of the difference between the actual and the adjusted end-tidal PCO2 or PO2.


Input: Fli-1 is a proto-oncogene which is rearranged in tumors induced by three different retroviruses, Cas-Br-E, F-MuLV, and 10A1.


Input: Routine imaging modalities revealed a total of 79 metastases.


Input: Cervical CT revealed an irregular low density at the periphery of the cervical vertebra from the C2 to C4 level.


Input: Human myotonic dystrophy protein kinase (DMPK) is a member of a novel class of multidomain protein kinases that regulate cell size and shape in a variety of organisms.

Human myotonic dystrophy protein kinase

DMPK


Input: The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3.

MAP kinase kinase kinase MLK2

JNK

kinesin superfamily


Input: Sequential immunoprecipitation showed all detectable p53 to be of the PAb246 + class in each LPV-transformed cell line, suggesting that the stable p53 was indeed wild type.

PAb246 +


Input: In this study, transcriptional fusions were constructed between the xcpP and xcpR genes and the lacZ reporter.

xcpP

xcpR genes

lacZ reporter


Input: Increased platelet-derived growth factor production and intimal thickening during healing of Dacron grafts in a canine model.

platelet-derived growth factor


Input: Interestingly, the NES mutant proteins appeared to have altered interactions with the splicing complex, binding more tightly to SC35 in co-immunoprecipitation assays.

NES mutant proteins


Input: The results of these studies indicate that EHV-1 gp13 is the structural homolog of herpes simplex virus glycoprotein C and further suggest that the epitope-containing N-terminal amino acid sequences of the herpesvirus gC-like glycoproteins have undergone more extensive evolutionary divergence than the C-terminal sequences.

EHV-1 gp13

herpes simplex virus glycoprotein C

herpesvirus gC-like glycoproteins


Input: Previously, a cDNA (GT2) encoding this protein was isolated from a mouse 3T3-L1 adipocyte library and was sequenced.


Input: By RT-PCR, different levels of E75 expression can be detected in the epidermis, nerve cord and the eyestalk of early pre-molt shrimp.


Input: PATIENTS: 33 HIV-infected, zidovudine-experienced patients with serum HIV RNA levels of at least 20, 000 copies/mL and CD4 counts ranging from 50 to 400 cells/mm3.


Input: The potential biological significance of the identified structural motif shared by the human CCR5, CCR3, CCR2B and other GPCRs is discussed.

human CCR5

GPCRs


Input: Materials are presented of a comparative study of morphological and cultural properties and virulence of liophylized cultures of Leishmania tropica major after their rehydration or after a long passage on the NNN medium.


Input: The chromosomal location of these YACs was verified using FISH, which also demonstrated their nonchimeric nature.


Input: There is no indication from these experiments that linker histones bind fundamentally differently to 5 S and bulk nucleosomes.

linker histones

5 S


Input: Gas chromatographic analysis of headspace samples of alkalinized vaginal discharges indicated the presence of trimethylamine in all 11 samples with the fishy odor but not in the other samples.


Input: To investigate the step of spliceosome assembly at which Snu17p acts, we have used nondenaturing gel electrophoresis.


Input: The transcription start site was identified by primer extension analysis and over 800 bp of 5' flanking DNA was sequenced.


Input: PURPOSE: To evaluate the effect of adding a pulsating bristle action to the established oscillating/rotating action of the Braun Oral-B Ultra Plaque Remover (D9) on plaque removal.


Input: In contrast, postmitotic neurons possessed extremely low levels of E2F1 protein as assessed by the electrophoretic mobility shift assay and Western blotting.

E2F1 protein


Input: The high degree of sequence conservation together with the ability to direct nucleolar protein transport supports the hypothesis that MAK16 proteins play a key role in the biogenesis of 60S subunits.

MAK16 proteins

60S subunits


Input: NO2 pollution on major trunk roads frequently exceeded British and European Union air quality standards, while particle pollution was lower.


Input: The human RFC-1 gene differs from the mouse and hamster genes both in terms of the total number of exons and in regard to alternatives of exon 1 which encode 5' end heterogeneity.

RFC-1 gene


Input: Computer analysis, simple correlation hypothesis, and distribution method with 1 degree of freedom revealed significant correlation between vertical root fracture and the technique of instrumentation and obturation of the canal (p = 0. 025), the length of the post (p = 0. 05), and the existence of the post (p = 0. 05).


Input: CrkII and CrkL constitutively formed complex with the guanine nucleotide exchange factor C3G, in unstimulated as well as PDGF-stimulated cells.

CrkII

CrkL

guanine nucleotide exchange factor C3G

PDGF


Input: Plasmid subclones of recombinant phage lambda Asm152 were able to complement both Escherichia coli gltB and A. sesbaniae Asm-Vi mutants; NADPH-glutamate synthase activity was detected in all such strains complemented to Asm +.

Escherichia coli gltB

NADPH-glutamate synthase


Input: Any respectative material (class 0) was not obtained from 334 patients (4. 2%), class I-II findings belonged to 6m141 patients (76. 7%), 950 patients (11. 9%) were classified as class HII and IV, 578 patients (7. 2%) as class V.


Input: DSIP was found to significantly increase slow-waves (delta sleep) in the sleep EEG.


Input: YDL003w (also termed MCD1) is a homologue of Schizosaccharomyces pombe rad21, an essential gene implicated in DNA double-strand break repair and nuclear organization in fission yeast.

Schizosaccharomyces pombe rad21


Input: The oral movements which did occur in the HAL-treated rats were slower than normal.


Input: The recombinant L/F-transferase is as active as the previously purified wild type enzyme and contains no detectable RNA component.

recombinant L/F-transferase


Input: AST activity in PMNs was significantly low, approximately 2% of that observed in HPLFs.

AST


Input: Two courses of chemotherapy (CBCDA + VDS) failed to gain any improvement, and the pain resulting from recurrent bone metastases was managed mainly by the administration of the best supportive care.


Input: Intraspinal and mediastinal foregut cyst compressing the spinal cord.


Input: The H5 mutants were: DH5 (all amino acids in D configuration) and H5F (where all His are replaced by Phe at positions 3, 7, 8, 15, 18, 19, 21).

H5 mutants


Input: Accordingly, infection of IFN-pretreated HeLa S3 cells with an E3L-deficient VV (VVDeltaE3L) resulted in increased phosphorylation levels of both PKR and eIF2alpha.

IFN

PKR


Input: The human sequence contains the element TGACTCT that also is found in a murine ras-responsive enhancer.

murine ras-responsive enhancer


Input: GAGA factor is known to remodel the chromatin structure in concert with nucleosome-remodeling factor NURF in a Drosophila embryonic S150 extract.

GAGA factor

nucleosome-remodeling factor NURF


Input: We report the complete nucleotide sequence of the camC gene along with 155 base pairs of 5' and 175 base pairs of 3' flanking sequence.

camC gene


Input: After 30 weeks of amifostine therapy, the morphology of the MDS switched to a chronic myelomonocytic leukemia (CMML)-like appearance, with continuously increasing leukocytes, so that we discontinued amifostine therapy for 1 month to exclude a possible side effect of amifostine.


Input: A gene with a high degree of sequence identity with mammalian ADP-ribosylation factors (ARFs), believed to be important in vesicular transport, was identified.

mammalian ADP-ribosylation factors

ARFs


Input: Theophylline QID, TID, BID and now QD? A report on 24-hour dosing with slow-release theophylline formulations with emphasis on analyses of data used to obtain Food and Drug Administration approval for Theo-24.


Input: We anticipated SNS function after CVA to be asymmetric and selected null hypotheses of bilaterally symmetric SSR latencies and amplitudes irrespective of side of stimulation and/or recording.


Input: Taken together, these results demonstrate that the BSMV coat protein is the sole translation product of the genomic RNA beta, whereas sgRNA beta 1 serves as a messenger for translation of the beta b protein, and sgRNA beta 2 functions as a messenger for translation of beta c and beta d and the newly discovered beta d' protein.

BSMV coat protein

genomic RNA beta

sgRNA beta 1

beta b protein

sgRNA beta 2

beta c

beta d

beta d' protein


Input: Without a team, there is little hope for fetal survival; mortality will be 80-100%.


Input: Thus, the search for genetic and acquired susceptibility to nontuberculous mycobacteria is also a search for susceptibility factors for MTB as well as an opportunity to recognize endogenous pathways that can be exploited therapeutically.


Input: This gene is divided into six exons spanning about 3kb, and encodes a 175 amino acid protein with 40-52% identity with the other five mouse Reg (regenerating gene product) proteins.

mouse Reg

regenerating gene product


Input: The RNA, whether antisense, ribozyme, or RNA aptamer, must be efficiently transcribed, stabilized against rapid degradation, folded correctly, and directed to the part of the cell where it can be most effective.


Input: Interconversions between haloperidol and reduced haloperidol in schizophrenic patients and guinea pigs: a steady-state study.


Input: PEAP was significantly higher in IDC patients compared to controls (48. 7 +/-32. 6 vs.


Input: Recurrent infections, episodic lymphopenia and impaired cellular immunity.


Input: Bilirubin and red cell metabolism in relation to neonatal jaundice.


Input: In this report, we describe a patient with renal cell carcinoma who experienced ventricular tachycardia while undergoing treatment with high-dose bolus IL-2.


Input: We report the cloning of the ade1 gene on a 4. 4 kb Sau3A insert in the yeast shuttle vector pWH5.

ade1 gene

4. 4 kb Sau3A insert


Input: We found that secretion of chitinolytic enzymes by cultured L. major parasites is inhibited by blood or hemoglobin, and hence these enzymes are apparently absent from the blood-fed infected flies, where the cardiac valve appears undamaged.

hemoglobin


Input: Oral hypoglycemic agents


Input: Identification and characterization of a yeast gene encoding the U2 small nuclear ribonucleoprotein particle B " protein.

U2 small nuclear ribonucleoprotein particle B " protein


Input: The false positive fraction (FPF) decreased significantly if the count density increased; no difference in FPF was found for a change in lesion tracer concentration.


Input: Members of the CRE-binding protein (CREB)/activating transcription factor transcription family as well as members of the Jun/Fos family have been shown to bind to this sequence.

CRE-binding protein

CREB

activating transcription factor

Jun

Fos


Input: Nature of the thermopower in bipolar semiconductors.


Input: Overexpression of SNURF in cultured mammalian cells enhanced not only androgen, glucocorticoid, and progesterone receptor-dependent transactivation but also basal transcription from steroid-regulated promoters.

SNURF

progesterone receptor


Input: Long-range mapping by pulse-field gel electrophoresis indicated that the three mdr genes are closely linked on a genomic DNA segment of approximately 625 kilobases.

mdr genes


Input: Oral basal body temperature (BBT) recordings of 46 women that conceived by donor insemination and who had midcycle monitoring of luteinising hormone (LH) were analysed to establish features associated with an optimal cycle.

luteinising hormone

LH


Input: At the start of the performance ride, plasma glucose averaged 4. 2 +/-0. 2, 5. 2 +/-0. 1, and 5. 7 +/-0. 2 mmol. l-1 in CON, CHO-7, and CHO-0/21, respectively (all different, P < 0. 05).


Input: Adhesion was inhibited by mAbs against the COOH-terminus and central cell binding domains of fibronectin, as well as by the corresponding CS1 and RGD peptides.

fibronectin

RGD peptides


Input: Usher syndrome 1C (USH1C) is a congenital condition manifesting profound hearing loss, the absence of vestibular function, and eventual retinal degeneration.


Input: We have determined the complete cDNA sequence of rat plectin from a number of well-characterized overlapping lambda gt11 clones.

rat plectin


Input: Minute virus of mice NS1, an 83-kDa mainly nuclear phosphoprotein, is the only viral nonstructural protein required in all cell types and it is involved in multiple processes necessary for virus propagation.

Minute virus of mice NS1


Input: On the basis of these findings we suggest that the acceptor peptide binds the transferase in a beta-like conformation and that penultimate residue side chain steric interactions may play a role in determining extent that a given Ser or Thr is glycosylated.


Input: A higher median proportion of spirochaetes was observed in sites after diagnosis of loss of attachment.


Input: Conventional and digital radiography of the heart, aorta, and pulmonary vascularity.


Input: Copyright 1998 Academic Press.


Input: Although cDNA encoding a human phagocyte formyl peptide-binding protein has been reported recently (Boulay, F., Tardif, M., Brouchon, L., and Vignais, P.

human phagocyte formyl peptide-binding protein


Input: These results suggest that the PVB therapy is not sufficient to cure the cases with choriocarcinoma element or bulky metastasis.


Input: METHODS: A spatial counting approach in which the location of each and every PN and NP in the stratum pyramidale of sectors CA1-4 was applied to 11 normal control (CONs) and 10 SZs matched for age and postmortem interval, as well as 4 manic depressive (MD) subjects matched for age.


Input: No effect of 4 beta-phorbol 12-myristate 13-acetate was observed on the expression of hnRNP H.

hnRNP H


Input: For large breasts (> 70 mm) the use of X-ray sets such as the IGE DMR, which automatically select the beam quality for each breast, resulted in lower doses compared with sets using manual tube potential selection.


Input: First, ste12Delta cells differ from cells with disruptions of the upstream signaling elements (e. g., ste4Delta, ste20Delta, ste5Delta, ste11Delta, ste7Delta, or fus3Delta kss1Delta cells) in that they clearly retain some capacity for inducing Ste3p phosphorylation.

fus3Delta kss1Delta


Input: The Valpha and Vbeta domains have the canonical features of known teleost and mammalian TCR V domains, including conserved residues in the beginning of FR2 and at the end of FR3.

Valpha

Vbeta domains

teleost and mammalian TCR V domains


Input: Asthma diagnoses were made according to recommended National Asthma Expert Panel Guidelines.


Input: The atpA reading frame ends with four tandem UGA codons which overlap four tandem AUG codons initiating an unidentified reading frame, orf214.

atpA


Input: Deletion mutagenesis of the promoter indicated that a positive regulatory element (PRE) was likely to exist downstream of the UL94 mRNA start site, while a negative regulatory element (NRE) was present upstream of the TATA box.

UL94 mRNA start site


Input: An ERp60-like protein from the filarial parasite Dirofilaria immitis has both transglutaminase and protein disulfide isomerase activity.

ERp60-like protein


Input: Fos/Jun bound to an unacetylated nucleosome with only a 4-to 5-fold reduction in DNA binding affinity compared with naked DNA.

Fos

Jun


Input: Pediatric patients--handle with care.


Input: K.


Input: The extent of myocardial ischemia in the coronary sinus study was significantly correlated to the coronary diameters of the proximal and middle segments of the Ramus interventricularis anterior and the middle segment of the Ramus circumflexus (r = 0. 87, p < 0. 02).


Input: S1 nuclease analysis of the RNA from a number of QT6-LD clones gave similar results, indicating that the LD population was composed of viruses with similar but not identical deletion endpoints.

S1 nuclease


Input: The prevalence of ocular/adnexal SCC was significantly greater for all hair colors when compared with bay, brown, or black (P less than 0. 01).


Input: ZNS, in the mmolar range, scavenged hydroxyl and nitric oxide radicals in a dose-dependent manner.


Input: Murine ELAM-1 is encoded by a single-copy gene, spanning about 13 kb, which is structurally organized into 14 exons and 13 introns; very similar to that of its human counterpart.

Murine ELAM-1


Input: The three more slower migrating Stat5B bands observed in response to GH contain phosphorylated tyrosyl residues.

GH


Input: Protection levels of 33. 3%, 36. 6% and 37. 0% were achieved in groups which had received, respectively, 1000 20-krad cercariae, 1000 10-krad cercariae, 2000 40-krad cercariae and 2000 60-krad cercariae.


Input: During the 1st week of treatment all subjects received either mianserin 30 mg or clomipramine 75 mg once daily.


Input: EMBO (Eur.


Input: When stratifying FLM values < 34 and > 34 wks' gestation, again no difference was found in mean difference of L/S and LB before and after 34 wks.


Input: Are there any lessons to be learnt?


Input: The other five from within the SRO may provide an entrance point for the cloning of candidate genes for neuroblastoma.


Input: Three distinct human HDACs are homologous to RPD3, a yeast transcriptional regulator.

human HDACs


Input: The longest cDNA insert identified was 2. 2 kb and encoded the entire 462-amino acid open reading frame of rat CgA including an 18-amino acid hydrophobic signal peptide.

rat CgA


Input: The vaccine was at least 80% efficacious against Chlamydia and Campylobacter spp and appeared to be protective.


Input: The RPC31 gene encoding the C31 subunit of Saccharomyces cerevisiae RNA polymerase C (III) has been isolated, starting from a C-terminal fragment cloned on a lambda gt11 library.

RPC31 gene

C31 subunit of Saccharomyces cerevisiae RNA polymerase C (III)


Input: Slowly adapting type I mechanoreceptor discharge as a function of dynamic force versus dynamic displacement of glabrous skin of raccoon and squirrel monkey hand.


Input: The goal of this investigation was to determine whether BMIPP uptake can be used to differentiate viable myocardium from scar tissue soon after coronary thrombolysis for acute myocardial infarction.


Input: The same slice was imaged three times each with sequences using spatial presaturation or not.


Input: IRIS/GAS DNA also formed a number of specific complexes with constitutively expressed factors, none of which were affected by the above Abs.

IRIS

GAS


Input: Making sense out of oxygen sensor.


Input: Recovery rates of energy level and intracellular pH during stimulation at 100Hz were greater than those observed during stimulation at 30Hz.


Input: The Zn-15 DNA-binding domain comprises three zinc fingers separated by unusually long linker sequences that would be expected to interrupt specific DNA site recognition.

Zn-15 DNA-binding domain


Input: The data obtained included 1) the mean frequency of abnormal teased myelinated fibers and its upper limit value of 95% confidence interval, and 2) the mean densities of total, large and small myelinated fibers and of unmyelinated fibers and their lower limit value of 95% confidence interval for each decade.


Input: The yield of endocervical cells and the incidence of dysplasia was determined for both the prenatal and the postpartum Pap smears performed for this group of patients.


Input: Others as for example C-11 labeled short chain fatty acids are on the horizon.


Input: We conclude that the BR-C early gene directly activates late gene transcription by interacting with late gene cis-acting regulatory elements and that this interaction is responsible for the temporal linkage of early and late ecdysone-induced gene expression.

BR-C early gene

late gene

late gene


Input: Exogenous heart stress raised log circulating NE concentration in proportion to the rise in heart rate at a given work load so that the usual relationship between these variables, previously observed during other stresses, was preserved.


Input: We tested the hypothesis that PEH is associated with reductions in TPR and sympathetic nerve activity (SNA).


Input: A short conserved motif is required for repressor domain function in the myeloid-specific transcription factor CCAAT/enhancer-binding protein epsilon.

CCAAT/enhancer-binding protein epsilon


Input: Purified fER exhibited a distribution constant (KD) for 17 beta-estradiol of 0. 45 nM.

fER


Input: However, strains in which both of the two most highly related genes, DdPIK1 and DdPIK2, were disrupted showed both growth and developmental defects, while double knockouts of DdPIK1 and DdPIK3 and DdPIK2 and DdPIK3 appear to be lethal.


Input: The exon sequences determined from genomic DNA sequencing showed some differences when compared to the published rat GLUT2 cDNA.

rat GLUT2 cDNA


Input: 48. 35 +/-5. 07 mg/l in R3; p < 0. 05) and in the AUC (0. 50 h) (1429. 92 +/-284. 23 in PR vs.


Input: This integration results in the production of MMTV/mdr3 fusion transcripts that originate from the antisense 5' LTR of the provirus.

MMTV/mdr3 fusion transcripts

5' LTR


Input: This surface in specimens from unfertilized eggs is almost flat.


Input: Following 40 min " ischemia ", preparations treated with PC recovered from transmural conduction block more rapidly (PC1 group, 4 min, P less than 0. 05; PC2 group, 23 min, ns), compared to control. (ABSTRACT TRUNCATED AT 250 WORDS)


Input: These results are discussed in the context of a model of the myogenic lineage that is based on the expression of desmin.

desmin


Input: Characterization of a DEAD box ATPase/RNA helicase protein of Arabidopsis thaliana.

DEAD box ATPase

RNA helicase


Input: The host range (HR) of poliovirus is thought to be primarily determined by a cell surface molecule that functions as poliovirus receptor (PVR), since it has been shown that transgenic mice are made poliovirus sensitive by introducing the human PVR gene into the genome.

poliovirus receptor

PVR

human PVR gene


Input: In this paper, the authors used measured weight for 1, 259 white women aged 65-74 years from the Epidemiologic Follow-up Study of the First National Health and Nutrition Examination Survey to examine the effect of overweight on coronary heart disease incidence (mean length of follow-up, 14 years).


Input: In contrast to the reciprocal effects of Gab1 and Gab2 in mediating Elk-1 induction, these two molecules have a similar function in extracellular signal-regulated kinase activation induced by either oncogenic Ras or growth factor stimulation.

extracellular signal-regulated kinase

Ras


Input: We were able to demonstrate a significant statistical interaction effect between gender and globulin protein concentration on Vu (p = 0. 022).

globulin protein


Input: The NS-2 isoforms were resolved at a pI value close to 5. 5 as three groups of unevenly phosphorylated polypeptides, each composed of at least two protein species.

NS-2 isoforms


Input: Effect of isobarin on electrocardiographic indices in hypertensive disease


Input: The column densities of frozen molecular hydrogen and methanol are inferred to be about 2. 5 x 10 (18) and 3. 0 x 10 (19), respectively.


Input: TAAG sites that serve as functional late promoters in OpMNPV were found to mediate transcription initiation at only basal levels in the context of the AcMNPV genome, suggesting that late promoter activation may be virus specific within the family Baculoviridae.


Input: The carboxyl globular domain was found to be encoded by six exons which appear to delineate its structural subdomains.


Input: In 3 of the 5 patients with AVNRT and AJR, junctional beats served as a trigger for reentry.


Input: Fus3p and Kss1p together increase the expression of CLN3 and PCL2 genes that promote budding, and Kss1p inhibits the MAP kinase cascade.

PCL2 genes

MAP kinase


Input: Measurement of the spectral sensitivity and the ERG can thus help in the diagnosis of these three hereditary diseases.


Input: On both indocyanine green video and fluorescein angiography, hypofluorescent lesions were almost the same size as the light yellow area and the dark yellow center of a placoid lesion.


Input: Other similar patients must be found before it is established that the colloid cyst is part of the nevoid basal cell carcinoma syndrome.


Input: Coexpression of C/EBP alpha altered the cell specificity.

C/EBP alpha


Input: Dominant-negative mutations in the G-protein-coupled alpha-factor receptor map to the extracellular ends of the transmembrane segments.

G-protein-coupled alpha-factor receptor


Input: Possibility of using gynecologic nurses in the independently administered health centers


Input: Platelet count and plasma volume were significantly higher in group A than in group B throughout pregnancy.


Input: The complexity of some of the reports of VACURG studies has led some to believe that this group was opposed to estrogens, but that is not true.


Input: This increase is not the result of alterations in the deposition of inhaled particles of capsaicin brought about by volume restriction.


Input: Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1.

IFN-gamma


Input: Pituitary thyrotropic adenoma associated with congenital hypothyroidism.


Input: Upstream of the afa-3 gene cluster, a 1. 2-kb region was found to be 96% identical to the RepFIB sequence of one of the enterotoxigenic E. coli plasmids (P307), suggesting a common ancestor plasmid.

afa-3 gene cluster

RepFIB sequence


Input: Maintenance metabolizable-energy (ME) requirement averaged 31. 0 kcal/kg body wt.


Input: Interferon-alpha inducibility of IFI16 may be regulated by an interferon-alpha/beta-stimulated response consensus element in the 5' UT exon, as a similar motif is conserved in the corresponding position in the related myeloid cell nuclear differentiation antigen gene. (ABSTRACT TRUNCATED AT 400 WORDS)

Interferon-alpha

interferon-alpha/beta

myeloid cell nuclear differentiation antigen


Input: The secondary end points included creatine kinase peak, ventricular fibrillation/tachycardia within the first 24 hours, death and congestive heart failure within the 30-day follow-up, and 30-day left ventricular ejection fraction.

creatine kinase


Input: For the population of patients with melanoma levels III and IV significant differences in survival rate were associated with thickness (less than 2 mm or greater than or equal to 2 mm; p less than 0, 001), though not with level.


Input: Here we show that the sck1 gene, cloned as a high copy number suppressor of a mutation in git3, is able to suppress the defects conferred by a mutation in any of these git genes.

sck1 gene

git genes


Input: The contribution of reviewers and editors to the scientific work of the authors


Input: Comparisons of defective HTLV-I proviruses predict the mode of origin and coding potential of internally deleted genomes.


Input: When proper controls were used, the psychophysical data and computer simulation gave remarkably comparable results.


Input: Results of these in vitro studies may be relevant to the pathogenesis of alveolitis in organic dust-induced lung diseases.


Input: However, the in vivo attachment strength of the CSTi-2 coating was comparable both to CSTi-1 and to an HA-coated control after 8 weeks.


Input: The phosphoprotein pUL69 of human cytomegalovirus (HCMV), which is a herpesvirus of considerable medical importance in immunosuppressed patients and newborns, has previously been identified as an early-late viral protein that can stimulate several viral and cellular promoters and thus exerts a rather broad activation pattern.

phosphoprotein pUL69

early-late viral protein


Input: Effects of acute exposure to cold on pulmonary arterial blood pressure in awake rats.


Input: RNase protection analysis reveals a 10-fold increase in the expression of SCD2 mRNA during 3T3-L1 preadipocyte differentiation.

RNase

SCD2 mRNA


Input: Spontaneous fracture of the tarsal bone in 2 cases of leprosy


Input: CERIP interaction.

CERIP


Input: The response sequences were localized between-67 and + 30 in the simian cytomegalovirus IE94 promoter and upstream of position + 9 in the HCMV IE68 promoter.

IE94 promoter

HCMV IE68 promoter


Input: The expression of Scmh1 and rae28/mph1 is well correlated in most tissues of embryos.


Input: Our results suggest that it might be possible to augment IN function in vivo through a heterologous domain.

IN


Input: Retinoic acid, which inhibits the progression of certain cancers, repressed v-src-induced MMP-1 transcription.

v-src


Input: Untransformed 3T3 cells carry abundant 1. 9 kb Hox 1. 3 RNA, whereas the methylcholanthrene-transformed MB66 and LTK-cells or 3T3 cells transformed by the oncogenes src, fos or SV40 T antigen express only low levels.

Hox 1. 3

src

fos

SV40 T antigen


Input: Furthermore, it is also established that serine phosphorylation of STAT5a transactivation domain, via the MAPK pathway, is a means of modifying GH-induced transcriptional activation.

MAPK

GH


Input: Prevention of gravid Rhesus isoimmunization


Input: Expression of medical efficiency by integration indicators with the rational utilization of budgeted funds


Input: We infer that RecA-mediated cleavage of UmuD is another role for RecA in SOS mutagenesis, probably activating UmuD for its mutagenic function.

RecA

UmuD

RecA

UmuD


Input: Blood pressure was controlled long term (with/without diuretics/beta-adrenoreceptor blocking drugs) in sixteen out of nineteen patients with mild-moderate hypertension.

beta-adrenoreceptor


Input: METHODS: Autocapture devices (Pacesetter Microny SR +/-and Regency SR +/-; Pacesetter, Solna, Sweden) and steroid-eluting epicardial pacing leads (Medtronic CapSure Epi 10366; Medtronic, Inc, Minneapolis, MN) were implanted in 14 children.


Input: This may be another example of the principle--less is more.


Input: The predicted amino-acid sequence includes an N-terminal signal sequence of 27 amino acids, a 27 amino-acid pro-region, a 251 amino-acid catalytic domain typical of a serine protease with trypsin-like specificity, and a C-terminal hydrophobic extension which is predicted to function as a membrane anchor.

serine protease

trypsin


Input: Effects of negative pi mesons on mouse bone marrow cells.


Input: Phenotypic and molecular analyses of patients with partial chromosome 21 monosomy enabled us to define a region, spanning 2. 4 Mb between D21S190 and D21S226, associated with arthrogryposis, mental retardation, hypertonia, and several facial anomalies.


Input: Relation between circulating immune complexes and serum ferritin in hemosiderosis of different etiologies

serum ferritin


Input: The zinc finger protein A20 is a tumor necrosis factor (TNF)-and interleukin 1 (IL-1)-inducible protein that negatively regulates nuclear factor-kappa B (NF-kappaB)-dependent gene expression.

zinc finger protein A20

tumor necrosis factor

TNF

interleukin 1

nuclear factor-kappa B

NF-kappaB


Input: The determination of antithrombin III (AT III) and its clinical significance

antithrombin III

AT III


Input: Treatments were two adrenocorticotrophin (ACTH) preparations given intramuscularly at 2. 2 U/kg, one of the ACTH preparations given intramuscularly at 1 U/kg and a synthetic polypeptide with ACTH-like activity (tetracosactrin, cosyntropin) given intravenously at 5 micrograms/kg.

adrenocorticotrophin

ACTH

ACTH

ACTH-like


Input: The deviation site is equivalent to the exon 1/exon 2 splice site of the mouse C-subunit.


Input: The liver-specific sequence contains unique consensus sites for phosphorylation by cyclic AMP-dependent protein kinase and by protein kinase C.

cyclic AMP-dependent protein kinase

protein kinase C


Input: Seizure recurrence (HR 1. 30; 95% CI = 0. 84, 2. 01) and antiepileptic drug treatment (HR 0. 97; 95% CI = 0. 67, 1. 38) did not influence mortality rate.


Input: All patients whose PSA levels reached 0. 1 ng./ml.

PSA


Input: The (0 0 2) diffraction of the synthesized HAp crystals on a Col fiber showed an around 60 arching angle, while that on a ChS fiber showed just around 10 degrees.


Input: Fas (APO-1/CD95), which is a member of the tumor necrosis factor receptor superfamily, is a cell surface receptor that induces apoptosis.

Fas

tumor necrosis factor receptor superfamily


Input: Soft independent modelling of class analogy (SIMCA) is applied to identify near-infrared (NIR) spectra of ten excipients used in the pharmaceutical industry.


Input: Mutations of SIN4, ROX3, SRB8, SRB9, SRB10, SRB11, and two novel genes, NUT1 and NUT2, relieve the requirement of Swi4p for expression of this reporter.


Input: The IB2 gene (HGMW-approved symbol MAPK8IP2) maps to human chromosome 22q13 and contains 10 coding exons.

IB2 gene


Input: Implantation is contraindicated for severe dysplasia of the cochlea and for the recently described variety of x-linked deafness with deficient bone at the fundus of the internal auditory meatus.


Input: The RsmA-mutant, like its parent, produces N-(3-oxohexanoyl)-L-homoserine lactone (HSL), a starvation/cell density-sensing signal required for extracellular enzyme production.

RsmA-mutant


Input: The 101st annual meeting of the Japanese Ophthalmological Society.


Input: The other end of this cluster contained the human type I cytokeratin K20 and K12 gene loci.

human type I cytokeratin K20

K12 gene


Input: In patients in which these criteria were not met only the reproducibility of the VO2 obtained in both the P-MET and the C-MET indicated that the maximal VO2 for these 4 patients had been reached.


Input: In the case of the pT181 plasmid, inactivation of the initiator RepC protein occurs by the attachment of an oligonucleotide to its active tyrosine residue.

initiator RepC protein


Input: We found multiple transcription start sites located within a 15-base pair region, 205 base pairs upstream of the translation start codon.


Input: Overexpression of either Sp1 or phosphorylated CREB transactivated the mCgA promoter dose dependently, while coexpression of both transcription factors resulted in an additive mCgA promoter response. mCgA-92 to-64 bp, comprising the Sp1/Egr-1 site and the CRE motif, conferred gastrin responsiveness to a heterologous thymidine kinase promoter system, and therefore functions as a " true " enhancer element.

phosphorylated CREB

mCgA promoter

mCgA promoter

mCgA

gastrin

heterologous thymidine kinase promoter


Input: Alfalfa phosphorus release kinetics showed high bacterial phosphorus contamination.


Input: In conclusion, ORCA3 regulates jasmonate-responsive expression of the Str gene via direct interaction with the JERE.

Str gene


Input: PC12 cultures that had been " primed " in this way showed an accelerated and augmented differentiation response to nerve growth factor.

nerve growth factor


Input: Pseudotumor form of pulmonary nocardia infection (Nocardia nova) in a renal transplant patient


Input: Deoxyuridine-suppression test and bone marrow culture for the diagnosis of macrocytic refractory anaemias.


Input: A computerized database of veterans discharged from the military after 1967 was selected as the source because it contains about 50% of the total Vietnam era veteran population, is reasonably unbiased, and provides a feasible method for identifying twins.


Input: We report that Nim1 possesses intrinsic serine-kinase, threonine-kinase and tyrosine-kinase activities.

serine-kinase

threonine-kinase

tyrosine-kinase


Input: This mutation was associated with reduced or absent expression of TGF-beta RI protein and p53 protein in tumor tissues.

TGF-beta RI protein

p53 protein


Input: Keys can be used for identifying species from the European part of the USSR and north-eastern Kazakhstan.


Input: Time between tests (usually less than one year) did not affect the correlations, but MMPI response-set variables (L, F, K, F-K) did.


Input: Cloning and sequence analysis of a chymotrypsinlike protease from Treponema denticola.

chymotrypsinlike protease from Treponema


Input: To initiate our analysis of factors required for eIF-2 alpha expression, selected a CAP-proximal element shown by in vivo methylation protection analysis to bind a potential regulatory factor.

eIF-2 alpha


Input: The isoproterenol infusion was adjusted so that heart rate (HR) was at least 30 beats/min greater than baseline.


Input: The effect of monaural middle ear destruction on postnatal development of mouse inferior colliculus.


Input: The specificity and sensitivity of this method (limit of detection in plasma 0. 025 micrograms/mL and < or = 0. 0125 micrograms/mL for febantel and its metabolites, respectively) were sufficiently high to enable us to characterize the time course of the drug in the plasma after oral administration of therapeutic doses to sheep.


Input: MATERIALS AND METHODS: A seven-wavelength frequency-domain photon migration probe was used to perform noninvasive NIR measurements in the breasts of 28 healthy women, both pre-and postmenopausal, aged 18-64 years.


Input: Drug therapy of AAPMC is directed at reducing the amount of Cl. difficile in the colon and promoting normalization of intestinal flora.


Input: The results of this study demonstrate that release of a single pulley after repair of the tendons in this area improved gliding excursions of the tendons and reduced resistance to motion of the repaired tendons, and provide support for partial A2 pulley incision after repair of the tendons in the area of the pulley.


Input: The Ick protein tyrosine kinase is not involved in antibody-mediated CD4 (CDR3-loop) signal transduction that inhibits HIV-1 transcription.

Ick protein tyrosine kinase


Input: It is targeted to peroxisomes when expressed in mammalian cells and yeast.


Input: Whether or not these novel repeated sequences throughout the SMA region are involved in the disease remains to be determined.

SMA region


Input: All except the last two interventions are physical treatments that create a wound-tissue environment conducive to healing.


Input: Consistent with our observation that AP-1 binding does not contribute to c-Jun coactivation is the observation that the activation of PU. 1 by c-Jun is blocked by overexpression of c-Fos.

c-Jun

PU. 1

c-Jun

c-Fos


Input: In a series of papers, the staging system for melanoma was critically analyzed, and many shortcomings were identified.


Input: The transcriptional initiation site of RAG1 was localized at A, 26 bp upstream of the putative translational initiation codon, ATG, by the primer extension assay.


Input: The levels of products expressed from these chimeric cDNAs in COS cells were assessed by activity assay and by metabolic labeling of the proteins followed by immunoprecipitation and SDS-PAGE.


Input: The leucine zipper region of ATF proteins is also similar to that of the AP-1/c-jun family of transcription factors, whose DNA-binding site differs from the ATF-binding site at a single position.

ATF proteins

c-jun

ATF


Input: Immunoblotting with antiphosphotyrosine antibody showed that many yeast proteins, including the p34CDC28 kinase, became phosphorylated at tyrosine in cells expressing v-src.

p34CDC28 kinase

v-src


Input: 22-Veneto Region)


Input: Differential transcription of plastome-encoded genes in the mesophyll and bundle-sheath chloroplasts of the monocotyledonous NADP-malic enzyme-type C4 plants maize and Sorghum.

malic enzyme


Input: AIMS: We postulated that perhexiline, a novel anti-ischaemic agent with an oxygen-sparing metabolic effect in the myocardium (via inhibition of carnitine palmitoyltransferase-1) and no adverse haemodynamic effects, may improve symptomatic status in elderly patients with severe aortic stenosis.

carnitine palmitoyltransferase-1


Input: Developmentally-regulated interaction of a transcription factor complex containing CDP/cut with the early histone H3 gene promoter of the sea urchin Tetrapygus niger is associated with changes in chromatin structure and gene expression.

CDP

cut

early histone H3 gene promoter of the sea urchin Tetrapygus niger


Input: In this group of patients, the mean LH (9. 3 +/-5. 9 IU/l) and sex-hormone binding globulin (SHBG) (54. 5 +/-22. 9 nmol/l) concentrations were significantly greater than those of five normal control subjects (4. 7 +/-1. 11 IU/l and 26. 0 +/-7. 0 nmol/l respectively).

LH

sex-hormone binding globulin

SHBG


Input: IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein.

ras GTPase-activating protein


Input: Gastrin stimulates transcription of the human histidine decarboxylase (HDC) gene through binding to the G-protein-coupled cholecystokinin-B/gastrin receptor.

Gastrin

human histidine decarboxylase

HDC

G-protein

cholecystokinin-B

gastrin receptor


Input: RESULTS--The maximal early asthmatic response after allergen with placebo treatment was 18. 4% (SE 4. 4%) and with WEB 2086 18. 9% (4. 4%).


Input: The 3' region of the transcript contained a fully conserved, correctly spliced TCR alpha C region which was polyadenylated at the 3' end.

TCR alpha C region


Input: Structural organization of the human Elk1 gene and its processed pseudogene Elk2.

human Elk1 gene

pseudogene Elk2


Input: Results: hepatic hydatidosis: 177 patients.


Input: Prematurely inactivating p42 MAPK in egg extracts resulted in a corresponding hastening of the first mitosis.

p42 MAPK


Input: Anxiogenic effects of pentagastrin in patients with social phobia and healthy controls.


Input: Dynamic expression of broad-complex isoforms mediates temporal control of an ecdysteroid target gene at the onset of Drosophila metamorphosis.

broad-complex isoforms


Input: Identification of a putative chromosomal replication origin from Helicobacter pylori and its interaction with the initiator protein DnaA.

initiator protein DnaA


Input: There was 91% concordance between ST-RD/RI/LRD 201Tl and R-ST/N + Inf 99Tcm-tetrofosmin imaging regarding reversibility.


Input: Sub-inhibitory and post-antibiotic effects of spiramycin and erythromycin on Staphylococcus aureus.


Input: There remains the physiological problem--one which has always been foremost in Moruzzi' s thinking about the intrinsic regulation of brain activity--of how the separate actions of the different arousal systems are brought together into a functional whole.


Input: Because the variation in the carbohydrate content of human milk is very small, a more simple alternative approach would be to include only an average carbohydrate value for an estimate of energy content.


Input: It is suggested that biliary secretion of both TBZ and FBZ and their metabolites may contribute to this recycling.


Input: Hyperlipemia has been recently described in children with migraine, being suggested that this alteration is in the base of the disease.


Input: BACKGROUND: A thorough understanding of malignant fibrous histiocytoma (MFH), the most common subtype of soft tissue sarcoma, will lead to improved histologic-specific protocols.


Input: The proteins encoded by these genes, called GF14 proteins, participate in protein/DNA complexes and show more than 60% identity with a highly conserved, widely distributed protein family, collectively referred to as 14-3-3 proteins.

GF14 proteins


Input: A total of 64 uncomplicated Type-2 diabetic individuals of higher middle class to rich socio-economic status were studied.


Input: Using yeast two-hybrid screening, we isolated histone H3 as an interacting factor of CIA.

histone H3

CIA


Input: Elevated total serum calcium to a level of 11. 9 +/-0. 2 mg/dl (p less than 0. 001 compared to control group) developed in the gentamicin/1, 25 (OH) 2 vitamin D3 group on day 4, 2 days prior to pronounced structural damage, and continued to be elevated through day 7.


Input: To investigate the role of this domain in the incorporation of the SIV Env into virions, we generated a series of SIV Env mutants carrying small in-frame deletions within the cytoplasmic domain.

SIV Env

SIV Env mutants


Input: Ozone uptake was assessed in awake, spontaneously breathing Fischer-344 Sprague-Dawley, and Long-Evans rats and Hartley guinea pigs to provide data on the dosimetry of O3 in small laboratory animals.


Input: Treatment of steroid resistant rejection following renal transplantation: benefits and risks of OKT3 therapy.


Input: SETTING: University research laboratory.


Input: On the 3rd day after ischemia of the remained kidney for 30 min, structural components of the walls of the glomerular arterioles and those of the filtration-reabsorption barrier undergo certain ultrastructural changes, that with time elapsed (7, 14 days) gradually pass away, and amount of cells with hypertrophic processes increases.


Input: Non-finger-coding modules conserved among members of subfamilies of zinc finger genes have been described in the murine genome (finger-associated boxes, or FAX domain) and the human genome (Kruppel-associated boxes, or KRAB domain).

zinc finger genes

Kruppel-associated boxes

KRAB domain


Input: Binding of C/EBPs to all three spi 2. 3 3' UTR repressor sites, although rather weak, was confirmed by electrophoretic mobility shift assays that otherwise failed to reveal specific interactions with other liver nuclear proteins in vitro.

C/EBPs

spi 2. 3 3' UTR repressor sites


Input: The newly identified NF kappa B enhancer (TGGAAATTCC) is bound by a TNF alpha-induced nuclear protein and appears to be the key element in rapid transcription induction by TNF alpha (and TPA), while transactivation of this element is repressed by the ligand-bound glucocorticoid receptor.

NF kappa B enhancer

TNF alpha

TNF alpha

glucocorticoid receptor


Input: Despite the fact that biochemical estimates of bone turnover indicate that (short-term) administration of rhGH and IGF-I stimulates bone metabolism in non-osteoporotic older people, no significant changes have been observed in bone mineral density at the proximal femur.

rhGH

IGF-I


Input: Parental and vector-transfected MCF7 cells, which were sensitive to the growth-inhibitory effects of atRA, exhibited atRA-dependent retinoic acid receptor (RAR) transactivation and transrepression of 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity.

retinoic acid receptor

RAR


Input: Chemiluminescence induced by opsonized zymosan increased significantly (P less than 0. 05) after treatment with bacterial extracts, whereas no significant changes were observed in the fMLP-stimulated PMNs.


Input: Using the two-hybrid screening method, we have identified an additional component of the CCAAT-binding factor.

CCAAT-binding factor


Input: Our studies suggest that the helicase assembly protein is responsible for loading T4 gene 41 helicase specifically at replication forks, and that its binding sites for each arm must hold more than six, but not more than 12 nucleotides.

helicase

T4 gene 41 helicase


Input: These results strongly suggest that HSV-1 infection inhibits host cell splicing through the action of ICP27.


Input: Sci.


Input: In our initial studies, we treated MCF-7 cells with paclitaxel, which results in the arrest of cells in G1 with 4n DNA content (pseudo G1).


Input: A GTP/GDP exchange assay was used to assess the potential role of Ras in the pathway leading to ERK phosphorylation; DADLE failed to stimulate GTP/GDP exchange in comparison to PMA.

Ras

ERK


Input: The primary structures of the human KB cell (FR-KB1) folate receptor (FR) and of a human placental (FR-P2) FR, proteins important in cellular accumulation of folates, have been deduced from cDNA sequences.

human KB cell (FR-KB1) folate receptor

FR

human placental (FR-P2) FR


Input: Copyright 1999 Academic Press.


Input: Possible or definite neglect or abuse before 36 months of age was correlated with low DBH activity.

DBH


Input: The remaining 77 nucleotides at the 3' end of domain II and all of domains III (655 nucleotides) and IV (770 nucleotides) are not present in DIssE RNA.

DIssE RNA


Input: Changes in tension were monitored isometrically on spiral strips of freshly obtained bovine basilar arteries.


Input: The preparative regimen consisted of fractionated total body irradiation (TBI) and cyclophosphamide (CY).


Input: The dynamics of protozoa were studied in two groups of rumen-fistulated cattle fed on a basal diet of molasses ad lib., with oaten chaff given at 6 or 18 g/kg live weight.


Input: Consistent with the large pocket of Rb binding to TAF (II) 250, the large pocket domains of both p107 and p130 are able to bind to TAF (II) 250 in vivo.

Rb

TAF (II) 250

TAF (II) 250


Input: Patients with Eales' disease, chorioretinitis, central serous retinopathy, or malignant choroidal melanoma were tested for HLA antigen deviation.

HLA


Input: Comparison of the derived amino acid sequence with that of the HCMV UL99 gene product reveals 34. 8% identity in an overlap of 66 amino acids.

HCMV UL99 gene product


Input: White female cases were more likely to have worked as registered nurses than were the controls (OR = 1. 9, 95% CI = 1. 0-3. 5).


Input: Fentanyl citrate (0. 1 mL) and 2H5-fentanyl (internal standard, 0. 05 mL, 100 mg/L) were extracted with Toxi-A tubes (Toxi-Lab, Irvine, CA) and analyzed by gas chromatography-mass spectrometry.


Input: O5257 shows homology with the SAS2 protein and another hypothetical protein from yeast.

SAS2 protein


Input: Cotransfection of expression plasmids encoding the protein kinase A inhibitor, or an inactive protein kinase A (PKA) catalytic beta subunit, inhibited both forskolin and PACAP activation of chromogranin A transcription, revealing that PACAP-induced trans-activation is highly dependent on PKA.

protein kinase A

protein kinase A

PKA

PACAP

chromogranin A

PACAP

PKA


Input: Of all YASR syndromes, the highest stability was for the Anxious/Depressed scale.


Input: There was no difference in serum albumin and transferrin levels, but serum prealbumin levels in the group fed early were more desirable than those of the control group (from 15. 8 +/-2. 5 mg/dl to 28. 9 +/-3. 8 mg/dl vs from 18. 0 +/-2. 0 mg/dl to 25. 9 +/-3. 9 mg/dl).

serum albumin

transferrin

serum prealbumin


Input: The introduction gives also the history of Research Programme MZ-XVII and its implementation in several regions of Poland.


Input: The uap100 cis-acting, up-promoter, constitutive mutation is a duplication that comprises two GATA sites and suppresses weakly the AREA zinc finger mutation but does not alleviate the need for functional UAY and AREA proteins.

AREA zinc finger mutation

UAY

AREA proteins


Input: Significant differences were observed in the composition of nuclear transcription factors bound to cis-elements within the LDH/C proximal promoter region in somatic versus germ cells.

LDH/C proximal promoter region


Input: We conclude that although the G3 sequence contains two protein-binding motifs, the organization of the G3 enhancer-like element is not bipartite.


Input: With BCPP protocol, 12 achieved a complete response, 11 evidenced a 75% response, and 7 displayed a 50% response.


Input: The effects of tilmicosin administration in the feed at 400 mg/kg and an injection therapy of clinically diseased pigs with long-acting oxytetracycline (Terramycine LA) at 20 mg/kg bodyweight were compared.


Input: In 7 men and 1 woman who died suddenly the functionally important areas of myocardium in the sino-auricular area and the subendocardial layers of left ventricle were obtained by necropsy no more than 3 h after death, and then prepared for study by electron microscopy.


Input: Importantly, a single base change in the fifth position of the c-fos sequence (GGTCTnnnAGACC to GGTCA/GnnnAGACC) produced an element that bound the estrogen receptor and conferred estrogen-dependent transcriptional activation of a reporter gene.

c-fos sequence

estrogen receptor


Input: A preterm formula with a traditional corn oil/MCT blend containing 38% MCTs (MCT group) was compared to a new fat blend, designed to resemble human milk more, containing 6% MCTs (LCT group).


Input: The existence of a TFIIIB assembly pathway leading to the faithful transcription of natural eukaryotic tRNA genes in the absence of TFIIIC provides novel insights into the functional flexibility of the eukaryotic tRNA gene transcription machinery and on its evolution from an ancestral RNA polymerase III system relying on upstream, TATA-centered control elements.

TFIIIB

TFIIIC

RNA polymerase III


Input: Overexpression of N-terminal mutations disturbs mitosis and produces elongated cells, Using a PCR approach, we isolated a putative homologue of Prp4 from human and mouse cells.


Input: Successive 5' deletions of the [-326; + 20] type II sPLA2 promoter indicated that the region upstream of position-195 inhibits the transcription activity sixfold in HepG2 cells but not in HeLa cells.

type II sPLA2 promoter


Input: Pyridostigmine pretreatment was supplemented by therapy with two doses of an antidotal combination (A, TM, B) consisting of 0. 05 mg/kg atropine, 2. 24 mg/kg TMB-4, and 0. 4 mg/kg benactyzine which assured survival in five of six animals following three separate exposures to 10 LD50 soman.


Input: Electrophoretic mobility shift assays and DNase I protection analyses revealed that FP I was bound by the transcription factor PU. 1/Spi-1.

DNase I

FP I

PU. 1


Input: Moreover, the noncoordinate effects of FSK on PMA-stimulated MKK and MAPK activities indicates the presence of a additional distal cAMP-dependent inhibitory mechanisms.

FSK

MKK

MAPK


Input: Motilin serum levels were measured for one hour.

Motilin


Input: Parameters of sperm quality were evaluated before and after freezing/thawing.


Input: Comment on " Critical behavior of a binary mixture of protein and salt water "


Input: Site-directed mutagenesis was conducted to investigate the functional significance of this element and the 3' minus-strand terminal sequence " 3'-OH-CCCUAU, " which contains the minus-strand 3'-end sequence " 3'-OH-CC (1-2) (A/U) (A/U) (A/U) " found in all carmovirus RNAs.


Input: Characterization of a nuclear deformed epidermal autoregulatory factor-1 (DEAF-1)-related (NUDR) transcriptional regulator protein.

nuclear deformed epidermal autoregulatory factor-1

NUDR


Input: Cardiac lesion in exotoxic shock


Input: Effect of family visits on the blood pressure and heart rate of patients in the coronary-care unit.


Input: Prospects of chemosterilant and genetic control of rodents.


Input: Neurological toxicity occurred in 8/219 patients treated with fludarabine (FAMP), 30 mg/m2 per day and cytosine arabinoside (Ara-C), 0. 5 g/m2 per hour for 2-6 hours for 5 days, for new or relapsed acute leukemia or myelodysplasia.


Input: Ondansetron is thus an effective first-line antiemetic in children undergoing chemotherapy, radiotherapy and surgery.


Input: Paclitaxel caused a rapid and transient increase in c-Jun NH2-terminal kinase (JNK) activity, a proposed mediator of stress activation pathways.

c-Jun NH2-terminal kinase

JNK


Input: Aspirin therapy in the rheumatic diseases.


Input: High-level expression of sccypB as well as of sccypA cloned into the expression vector pIJ702 did not produce detectable changes in growth and morphology of S. chrysomallus and S. lividans.

sccypB

sccypA


Input: Reasons are presented to support the contention that this increase is in part real.


Input: Expression of the Hox genes egl-5 and mab-5 is reduced in lin-49 and lin-59 mutants, suggesting lin-49 and lin-59 regulate HOM-C gene expression in C. elegans as the trx-G genes do in Drosophila. lin-49 and lin-59 transgenes are expressed widely throughout C. elegans animals.

Hox genes egl-5

lin-59 mutants

HOM-C gene

trx-G genes

lin-59 transgenes


Input: In cotransfection assays, a small fragment of Sin retaining the Src-SH3-binding site and one tyrosine-containing motif induced c-Src activation as measured by a transcriptional reporter.

Sin

Src

c-Src


Input: TFIIB and VDR can also interact directly, and these factors synergize to mediate transactivation.

TFIIB

VDR


Input: In addition, 269 mice from a (Mus spretus x C57BL/6J) F1 x C57BL/6J interspecific backcross were also used to order marker loci and calculate intergene distances for this region.


Input: Our findings suggest that AIF may be a morphologic correlate of tumor regression following preoperative cytotoxic chemotherapy.


Input: Hypocalcemia is usually due to either a disturbance in the parathyroid hormone-adenylate cyclase system or a disturbance in vitamin D metabolism.

parathyroid hormone

adenylate cyclase


Input: The system consists of a TV unit compatible to IBM PC/AT and software.


Input: Newly hatched F1 nymphs of Aiolopus thalassinus (Fabr.) were fed on food treated with various concentrations of HgCl2, CdCl2, and PbCl2 until the end of adult life.


Input: Reduced concentrations of antithrombin III, plasminogen, (free) protein S, and protein C were found in some patients but were not associated with either thrombosis or lupus anticoagulant.

antithrombin III

plasminogen

protein S

protein C


Input: UICC criteria) for VM and 35% for VE (not significant).


Input: Simvastatin decreased levels of total cholesterol by 20. 8%, LDL cholesterol by 29. 7%, triglycerides by 13. 6%, apolipoprotein B by 22. 4%, alpha-tocopherol by 16. 2%, beta-carotene by 19. 5%, and ubiquinol-10 by 22. 0% (P <. 001 for all) and increased levels of HDL cholesterol by 7. 0% (P <. 001) and serum insulin by 13. 2% (P =. 005).

LDL cholesterol

apolipoprotein B

HDL cholesterol

serum insulin


Input: Ultrasonography is a diagnostic alternative which may replace arthrography.


Input: Northern blot analysis with GPR37 probes revealed a main 3. 8-kb mRNA and a less abundant 8-kb mRNA, both expressed in human brain tissues, particularly in corpus callosum, medulla, putamen, and caudate nucleus.


Input: TNF-alpha effect was eliminated by a 2-bp substitution mutation in the NF-kappa B1 binding half site of the NF-kappa B cis element.

TNF-alpha

NF-kappa B1 binding half site

NF-kappa B cis element


Input: Three RasV12 mutants (S35, G37, and C40) which differ by their ability to bind to Ras effectors (Raf, Ral-GEFs, and the p110 subunit of PI 3-kinase, respectively) were able to induce sustained NR cell proliferation, although none of these mutants was reported to transform NIH 3T3 cells.

RasV12 mutants

Ras effectors

Raf

Ral-GEFs

p110 subunit of PI 3-kinase


Input: A possible correlation between mandibular growth retardation and palatal clefting is discussed.


Input: Total cross sections for electron scattering by CO2 molecules in the energy range 400-5000 eV.


Input: However, depending upon the promoter context, we observed cooperative interactions between the two domains to confer high DNA-binding affinity and specificity.


Input: RESEARCH DESIGN AND METHODS: A total of 26 IDDM patients with normoalbuminuria were randomized into two groups, with one group receiving placebo (n = 13, age 36 +/-3 years, BMI 24. 5 +/-1. 1 kg/m2) and the other group receiving an average of 15 mg lisinopril daily (n = 13, age 34 +/-2 years, BMI 24. 4 +/-0. 9 kg/m2).


Input: This experience would recommend consideration of home nutritional support in patients with systemic scleroderma when the disease is relatively stable and no major organ failure is present.


Input: Adult-onset parkinsonism has appeared in several previously unaffected members in families with DRD suggesting that this may be an additional phenotypical expression of the disease.


Input: Production of VT was also examined retrospectively in 32 E. coli strains of serotype O26: H11 isolated from children with diarrhoea; eight (25%) of them produced moderate to high levels of verotoxin 1 despite several years storage in vitro.

verotoxin 1


Input: The present study deals with the screening of 11 of these plants against the opportunistic pathogen fungus Candida albicans.


Input: The tam A gene of Aspergillus nidulans encodes a 739-amino acid protein with similarity to Uga35p/Dal81p/DurLp of Saccharomyces cerevisiae.

tam A gene of Aspergillus nidulans

DurLp


Input: The 5'-flanking region of the gene, approximately 1. 1 kbp long, had no known regulatory elements for transcription such as TATA, GC, and CCAAT boxes.


Input: The Molteno implant is an effective procedure in the treatment of complicated and refractory cases of glaucoma in high-risk eyes.


Input: Two of the three groups were submitted to two different levels of hypoxia (FiO2 = 0. 05, group F5 and FiO2 = 0. 1, group F10) and the third to normoxia (FiO2 = 0. 21, group F21) in a thermoneutral and controlled environment.


Input: Glutathione reductase (GR) was purified from the cyanobacterium Anabaena PCC 7120.

Glutathione reductase

GR


Input: Genotype-phenotype correlations in male patients with a partial nullisomy of the X chromosome have suggested that at least one locus involved in MRX is on Xp22. 3.


Input: On the other hand, NE transport and antagonist ([125I] RTI-55) binding assays on whole LLC-NET cells treated with tunicamycin reveal a pronounced reduction in NE transport activity and hNET membrane density paralleled by an inability of NET proteins to replenish the higher M (r) hNET pool.

hNET

NET proteins

hNET


Input: We have now completed the primary structure of fibrillin, elucidated the exon/intron organization of the gene and derived a physical map of the genetic locus.

fibrillin


Input: The deduced amino acid sequence of PutR (154 amino acid residues) showed homology to the small regulatory proteins Lrp, BkdR, and AsnC.

PutR

Lrp

BkdR

AsnC


Input: NF-kappaB only partially mediates Epstein-Barr virus latent membrane protein 1 activation of B cells.

NF-kappaB

Epstein-Barr virus latent membrane protein 1


Input: In contrast, stem-loop structures 2, 3, and 4 of the 3' domain showed great variations in size, sequence, and structure.


Input: Whereas Sprague-Dawleys displayed lights-off and lights-on peaks of ingestive activity, only a minority of Fisher-344s displayed a consistent lights-on peak of ingestive activity.


Input: The mammalian UPR is mediated by the cis-acting ER stress response element consisting of 19 nt (CCAATN (9) CCACG), the CCACG part of which is considered to provide specificity.


Input: Effects of dietary lipids on whole-body retention and organ distribution of organic and inorganic mercury in mice.


Input: This region shows 46% identity with the calmodulin-binding region of rat brain Ca2 +/calmodulin-dependent protein kinase II and 32% identity with the equivalent region of chicken smooth muscle myosin light chain kinase.

calmodulin-binding region

rat brain Ca2 +/calmodulin-dependent protein kinase II

chicken smooth muscle myosin light chain kinase


Input: 1H and 15N magnetic resonance assignments, secondary structure, and tertiary fold of Escherichia coli DnaJ (1-78).

Escherichia coli DnaJ (1-78)


Input: The effects of inoculum size, medium, temperature, and duration of growth on the in vitro susceptibility testing of Aspergillus fumigatus were investigated using broth micro-and macro-dilution techniques.


Input: Copyright 1998 Academic Press.


Input: This dynamic nature may be relevant to the ability of E47 both to homodimerize and to heterodimerize with MyoD, Id, and Tal1.

MyoD

Id


Input: We identified clones of Chlamydomonas genomic DNA that rescued the Ca (2 +)-dependent axonemal microtubule severing defect of fa1 mutants.

fa1 mutants


Input: STUDY SELECTION: Not applicable.


Input: Sequence and deletion analysis of the recombination enhancement gene (ref) of bacteriophage P1: evidence for promoter-operator and attenuator-antiterminator control.

recombination enhancement gene

ref


Input: Viral protein U (Vpu) is a protein encoded by human immunodeficiency virus type 1 (HIV-1) that promotes the degradation of the virus receptor, CD4, and enhances the release of virus particles from cells.

Viral protein U

Vpu


Input: There also may be osmotic challenges to mucosal cell function as evidenced by the different reaction rates with hyper-and hypotonic saline.


Input: The overall objective response rate (RR) was 50% [95% confidence interval (CI) = 29-71%] including four complete responses and eight partial responses.


Input: In spite of the variability of DD95 with regard to body weight, the recovery of neuromuscular transmission in the patients of the three groups is comparable.


Input: SH3A competes with the SH3 domains of Grb2 in binding to mSos1, and the intersectin-mSos1 complex can be separated from Grb2 by sucrose gradient centrifugation.

SH3 domains

intersectin


Input: Both oligonucleotide cross-competition and antibody supershift experiments established that the double-strand binding protein is equivalent to Sp1.


Input: The major transcription start site, designated as + 1, was determined by RACE (rapid amplification of cDNA ends) analysis of human liver cDNA and was found to be located 50 bp upstream from the translation start site.


Input: Kerstin takes the abbreviated medical education.


Input: Epithelial cells had abnormal and accelerated exfoliation which resulted in multifocal epithelial defects.


Input: Influenza virus-induced NF-kappaB-dependent gene expression is mediated by overexpression of viral proteins and involves oxidative radicals and activation of IkappaB kinase.

NF-kappaB-dependent gene

IkappaB kinase


Input: The Xenopus annexin II heavy chain lacks the highly conserved tyrosine at position 23 which is the site of src oncogene tyrosine kinase phosphorylation in the murine protein.

Xenopus annexin II heavy chain

src oncogene tyrosine kinase


Input: This demonstrates a relative independence of the given synchronizer of rhythmicity at a tissue level from any influence of the higher regulatory center.


Input: Two of the proteins UPRF-1 and UPRF-2 (which is apparently a proteolytic degradation product of UPRF-1) bind inefficiently to mutant versions of the UPR that are unable to confer responsiveness to unfolded proteins to the (CYC1) promoter.


Input: Since nearly all transformants involving homeologous DNAs carried a single recombinant plasmid in both Pms + and Pms-strains, stable heteroduplex DNA appears less likely than for homologous DNAs.

Pms +

Pms-


Input: Western and immunocytochemical analysis implied that PREB accumulates specifically in GH3 cell nuclei.

PREB


Input: Coronary arteries were found in the biopsy tissue of 30 (76%) of the 39 patients who formed the study group.


Input: Cotransfection of a junB stimulated the basal activity of the alpha 2 (I) collagen promoter 93-fold, respectively.

junB

alpha 2 (I) collagen promoter


Input: The extraordinary high substrate specificity of rPulA together with its thermal stability makes this enzyme a good candidate for biotechnological applications in the starch-processing industry.

rPulA


Input: An atypical form of juvenile myasthenia gravis associated with severe emaciation, muscle atrophy, ophthalmoplegia, bulbar signs and joint contracture


Input: Anesthesia was induced by droperidol 0. 2 mg. kg-1, fentanyl 50 micrograms, thiamylal 150-250 mg, and succinylcholine 1 mg. kg-1, and maintained with nitrous oxide and O2 (67: 33) supplemented with repeated i. v. doses of fentanyl (within 15 micrograms. kg-1).


Input: In this system, enhancers act primarily to increase the probability of rapid and efficient transcription complex formation and initiation.


Input: (i) p60 bound fast-migrating, underprocessed wild-type ICP22 and ICP22 lacking the carboxyl-terminal 24 amino acids but not ICP22 lacking the carboxyl-terminal 40 amino acids, whereas the previously identified cellular protein p78 (R.

wild-type ICP22

cellular protein p78


Input: Hetero-oligomerization of Smad4 with the pathway-restricted SMAD proteins is essential for Smad4-mediated transcription.

SMAD proteins


Input: This group showed the presence of bacteria infiltrated at the dentinal tubules coronally and into the root canals.


Input: Hydroxyl radical footprinting of DNA complexes of the ets domain of PU. 1 and its comparison to the crystal structure.

ets domain

PU. 1


Input: Autophosphorylation on the major phosphorylation site Y1235 upregulates the kinase activity of the receptor, increasing the Vmax of the phosphotransfer reaction.


Input: The generation of dorso-ventral polarity during Drosophila embryogenesis is regulated by the action of 12 maternally expressed gene products, the dorsal group.

dorsal group


Input: Immunoblot analysis of purified and protease-digested intracellular mature virus (IMV) and extracellular enveloped virus (EEV) showed that the A36R proteins were present on the surface of EEV with type II membrane topology, but were absent from IMV.

A36R proteins


Input: To prevent section wrinkles usually encountered with the use of coated single-hole grids, a simple method was developed.


Input: An alternative approach to random integration of large DNA fragments into plants is to utilize one of several site-specific recombination (SSR) systems, such as Cre/lox.

Cre

lox


Input: Both v-Myb and c-Myb bind specifically to delta E3.

v-Myb

c-Myb

delta E3


Input: After at least one year follow-up, argon laser showed a statistically significant effect (p less of 0, 01; Kolmogorow-Smirnov test) on the stabilization or the amelioration of visual acuity compared with the non treated group.


Input: As part of a large Dutch prospective multicenter study (Netherlands Cooperative Study on the Adequacy of Dialysis-2), we consecutively included all new patients with end-stage renal disease for whom residual renal function could be obtained 0 to 4 weeks before the start of dialysis therapy.


Input: Relationship between age-associated endocrine deficiencies and muscle function in elderly women: a cross-sectional study.


Input: Intensity variations from the variable TR were removed, and the data were evaluated for correlation with the lateralized stimulus.


Input: Improvement of some pharmaceutical properties of clofibrate by cyclodextrin complexation.


Input: We assessed cardiovascular variables and blood O2 contents in order to characterize O2 transport in ponies during treadmill exercise.


Input: Somatic and visceral inputs to the thoracic spinal cord of the cat: effects of noxious stimulation of the biliary system.


Input: Some of these DNA: protein complexes were also present, but at lower levels, in nuclear extracts from untransformed rat cells suggesting the possible involvement of cellular factors in the mechanism of down-regulation mediated by Ad12 E1A.

Ad12 E1A


Input: We suggest that the induction of IFNA promoter region requires cooperation between alpha F1 binding proteins and IRF-1.

IFNA promoter region

alpha F1 binding proteins


Input: Two pharmacokinetic models were compared.


Input: Morphine administration acutely reduced plasma clearance of sulfobromophthalein (BSP) in mice and increased hepatic retention of this dye.


Input: A Buddhist view of abortion.


Input: Cryoglobulinaemia among maintenance haemodialysis patients and its relation to hepatitis C infection.


Input: In HepG2 cells, SREBP-1c mRNA and precursor protein levels were induced by treatment with 22 (R)-hydroxycholesterol and 9-cis-retinoic acid, confirming that endogenous LXR-RXR activation can induce endogenous SREBP-1c expression.

SREBP-1c mRNA

LXR

RXR

endogenous SREBP-1c


Input: The T (CCO2) was related to the PCO2 by a Pearson product coefficient of 0. 79 (p <. 0005), with a mean difference of 1. 94 (T (CCO2) > P (CO2) and 95% confidence interval of-0. 12 to 4. 07.


Input: Comparison of the footprint patterns of the mouse and human HPRT genes demonstrated that the in vivo binding of regulatory proteins between these species is generally conserved but not identical.

mouse and human HPRT genes


Input: In this study, we sought to determine the specific effect of HIV protease inhibitors on patient weight.

HIV protease


Input: The cats with stage-2 lymphomas that were FeLV-test negative had the best response to treatment.


Input: E1 recognition sequences in the bovine papillomavirus type 1 origin of DNA replication: interaction between half sites of the inverted repeats.


Input: Phase I study of 5-fluorouracil and leucovorin by a 14-day circadian infusion in metastatic adenocarcinoma patients.


Input: Although polyubiquitin chains linked through Lys (29) of ubiquitin have been implicated in the targeting of certain substrates to proteasomes, the signaling properties of these chains are poorly understood.

polyubiquitin chains

ubiquitin


Input: B and C1 fusions with yeast GAL4 DNA-binding and transcriptional activation domains were also found to interact when synthesized and assayed in yeast.

B

C1 fusions

yeast GAL4 DNA-binding and transcriptional activation domains


Input: Deletion analysis of the 7. 3-kb GATA-2 promoter region revealed that a 1. 1-kb DNA sequence is critical for expression of GATA-2 in neurons.

7. 3-kb GATA-2 promoter region


Input: In this study, we verified that PI 3-kinase associates with the CD4: p56lck complex as judged by the presence of PI 3-phosphate generated from anti-CD4 immunoprecipitates and detected by high-pressure liquid chromatographic analysis.

PI 3-kinase

p56lck complex


Input: Reality and clinical application of immunoglobulin preparations

immunoglobulin


Input: This evidence, together with the ability of a carboxyl-terminal coding sequence starting from the BamHI site to complement a shy1 mutant, suggests that the Shy1p contains two domains that can be separately expressed to form a functional protein.

BamHI site

shy1 mutant


Input: We have previously shown that UNC-4 expression in the VA motor neurons specifies the wild-type pattern of presynaptic input.


Input: However, technical advances have shown the limitations of these tests as tests for IgM can be positive because of residual specific IgM or even in subjects free of acute infection due to the existence of natural interfering IgM.

IgM

IgM

IgM


Input: Transesophageal echocardiography risk factors for stroke in nonvalvular atrial fibrillation.


Input: Therefore, in VDR-mediated transcriptional activation, 1, 25 (OH) 2D3 binding to VDR alters the conformation of the ligand binding domain such that it: (i) engages in strong heterodimerization with RXR to facilitate VDRE binding, (ii) influences the RXR ligand binding domain such that it is resistant to the binding of 9-cis RA but active in recruiting coactivator to its AF-2 and (iii) presents the AF-2 region in VDR for coactivator association.

VDR

VDR

RXR

RXR ligand binding domain

VDR


Input: Our case, however, had no histologic evidence of malignancy, no serum alpha fetoprotein at 7 months of age, and no recurrence at 1 years.

serum alpha fetoprotein


Input: Second, overexpression of RIM11 can suppress an ime1 missense mutation (ime1-L321F) but not an ime1 deletion.


Input: It is always present and has a discrete origin and insertion.