Input: Based on the requirement for CREM/ICER and Rad6B proteins in spermatogenesis, we determined expression of Cdc34, Rad6B, CREM/ICER isoforms, and the Skp1-Cullin-F-box ubiquitin protein ligase subunits Cul-1 and Cul-2, which are associated with Cdc34 activity during murine testicular development.

CREM

ICER

Rad6B proteins

CREM

ICER

Cullin

ubiquitin


Input: Since the early 1900s, a genetic hypothesis has been suggested.


Input: Kettin is a large modular protein associated with thin filaments in the Z-disc region of insect muscles.

Kettin


Input: To probe the inter-relationship between the virion-anchoring function and the oligomerization function, we constructed two serotype 3 (T3) sigma 1 deletion mutants in SV40 expression vectors, one lacking the hydrophobic tail and the hinge, and the other lacking an adjacent region which constituted part of the coiled-coil.

sigma 1


Input: This is the first description of an integron located on a composite transposon.


Input: By means of early detection and correction of the possible causes, the goal of increasing therapeutic efficacy can be achieved.


Input: METHODS: Single white flash ERG, photopic ERG, scotopic ERG and flicker ERG were recorded in 30 cases of unilateral CRVO.


Input: RESULT (S): A prospective study was conducted with 44 cycles for 34 couples with nafarelin acetate (group 1) and 47 cycles for 40 couples with buserelin acetate (group 2) with a long IVF protocol; 68 cycles for 46 couples with nafarelin acetate (group 3) and 56 cycles for 39 couples with buserelin acetate (group 4) with a short IVF protocol; 39 cycles for 32 couples with nafarelin acetate (group 5) and 50 cycles for 30 couples with buserelin acetate (group 6) with a long ICSI protocol; and 87 cycles for 60 couples with nafarelin acetate (group 7) and 81 cycles for 61 couples with buserelin acetate (group 8) with a short ICSI protocol.


Input: Mutations in the beta-galactosidase gene result in the lysosomal storage disorders GM1-gangliosidosis and Morquio B syndrome.

beta-galactosidase gene


Input: Angiographic follow-up was obtained in 92% of patients with a primary success of angioplasty.


Input: However, it is only loosely associated, or not associated, with viral particles. gp170 is generated by an alternatively spliced Env mRNA using a splice donor and splice acceptor pair localized within the env open reading frame (ORF), which is normally used to generate Bell and Bet transcripts derived from the internal promoter within the env ORF. gp170 is expressed at a level 30 to 50% of the Env precursor gp130.

Env mRNA

env open reading frame (ORF)

Bell

Bet transcripts

env ORF

Env precursor gp130


Input: They are both insensitive to inhibitors of serine and aspartyl proteinases but are sensitive to sulfhydryl reagents and 0. 5 mM ZnCl2.

serine and aspartyl proteinases


Input: The Brassica BTH1 gene may correspond to the Arabidopsis TH-1 gene.

Brassica BTH1 gene

Arabidopsis TH-1 gene


Input: Electron microscopic visualization of the general population of active genes in flies overexpressing hnRNP proteins also indicated that the great majority of genes seemed normal in terms of cotranscriptional RNA processing events, although there were a few abnormalities consistent with rare exon-skipping events.

hnRNP proteins


Input: ESR spectra of Er3 + in SmB6 single crystals: Dynamic Jahn-Teller effect in a mixed-valence compound.


Input: T. infestans, T. delpontei, T. rubrovaria, T. sordida, T. guasayana and T. vitticeps from infestans subgroup and T. pallidipennis from rubrofasciata, were studied.


Input: When the same single-amino-acid mutations were directly introduced into the parental PV/CBV4-2A genome, chimeric viruses with a large-plaque phenotype and a wild-type PV-like growth pattern were obtained upon transfection, an observation demonstrating that these point mutations alone had a drastic effect on the growth of the PV/CBV4 chimeric virus.


Input: These results indicate that the 2127-bp cDNA encodes a functional feline L/B/K-type ALP expressed on cell surfaces via phosphatidylinositol-glycan linkage.

L/B/K-type ALP


Input: Clinical experience gained from a combined study of 252Cf brachytherapy by the staff-members of the Research Institute of Medical Radiology, USSR AMS, was generalized.


Input: When the VBP-1 protein was solely expressed, it located to the cytoplasm and did not localize to the nucleus.

VBP-1 protein


Input: Inhibition of endogenous Cdk2 by dominant negative Cdk2 attenuated phosphorylation of Thr447, Thr490 and Thr497, but had no effect upon Ser581 modification.

endogenous Cdk2

dominant negative Cdk2


Input: Treatment of excessive bleeding after cardiopulmonary bypass was based on an algorithm using point-of-care testing with whole blood prothrombin time, activated partial thromboplastin time, heparinase activated clotting time, and platelet count.

blood prothrombin

thromboplastin

heparinase


Input: Endocarditis remains a life-threatening disease with substantial morbidity and mortality.


Input: Association between diaphragm use and asymptomatic bacteriuria.


Input: The high prevalence of atrial septal defect in tetralogy of Fallot is cited as a possible analogy because right ventricular pressure is high and right ventricular compliance is low from birth.


Input: Experience in a Kenya district hospital


Input: Moreover, we studied the relationship between initial percentage of bone marrow plasma cells and prognosis.


Input: Analysis of larger cDNA clones demonstrates that there are at least two isoforms of RIP14 that differ in the N-terminal (A and B) and hinge (D) domains.


Input: A genomic clone of the chicken osteopontin-encoding gene (opn) was isolated and found to be organized as follows: an untranslated 5' exon; a signal peptide; a recognition sequence for phosphorylation by casein kinase II; a domain containing a possible O-linkage site for glycosylation; a second casein kinase II phosphorylation site; an exon containing three functional regions, the poly-Asp sequence of seven consecutive Asp residues, the RGD integrin recognition site and a potential N-linkage site for glycosylation; and a large C-terminal exon which also contains a potential N-linkage site for glycosylation.

chicken osteopontin-encoding gene

opn

casein kinase II

casein kinase II phosphorylation site

RGD integrin recognition site


Input: The entire coding region of an ovine endometrial oxytocin receptor (OTR) cDNA was generated by PCR, subcloned into the SV40 major late promoter expression vector pSVLJ and transiently expressed in Cos-7 cells.

ovine endometrial oxytocin receptor

OTR

SV40 major late promoter


Input: Copyright 1999 Academic Press.


Input: Critical review of tests for the HBs antigen in the detection of infectious blood

HBs antigen


Input: Diff-Quik stain for Tzanck smears.


Input: Disease-free interval was greater in node-negative Lx patients for both T1 (P less than 0. 007) and T2 (P less than 0. 05) presentations.


Input: Deletion analysis defines distinct functional domains for protein-protein and nucleic acid interactions in the ORF1 protein of mouse LINE-1.

ORF1 protein


Input: Allergen-stimulated levels of PGD2 were 1274 +/-565 versus 1468 +/-679 after prednisone; likewise, allergen-stimulated 5-HETE levels were 95 +/-21 versus 82 +/-21; those of LTE4 were 54 +/-20 versus 91 +/-51; and those of 15-HETE were 63 +/-19 versus 60 +/-25.


Input: To confirm the data obtained using the HPLC-ESI-MS procedure, fractions of the glycosides from four berries were separated, hydrolyzed, silylated and the sugars were analyzed using gas chromatography-mass spectrometry.


Input: Usefulness of computerized tomography in hemodialysis patients.


Input: Prevalence of use, claims volume, and expenditures were compared for cisapride, proton pump inhibitors, histamine-2 receptor antagonists, and the prokinetic agent metoclopramide during these periods.

histamine-2 receptor


Input: However, the quasiparticle scattering rate tau (-1) is such that Planck' s over 2pi/tau approximately 6t (perpendicular), implying that kappa-(BEDT-TTF) 2Cu (NCS) (2) meets the criterion used to identify interlayer incoherence.


Input: The deduced gene product was found to have significant sequence similarity to the yeast and prokaryotic RNA polymerase subunits involved with subunit assembly.

yeast and prokaryotic RNA polymerase subunits


Input: In two of these nine patients, a decrease in dyskinesia score was observed without a concomitant worsening of parkinsonian symptoms, whereas in the remaining seven, full parkinsonian akinesia followed THDL administration.


Input: However, an analogous myristoylated peptide derived from c-Yes also has no inhibitory activity.

c-Yes


Input: The expression of the leukocyte EL-246 antigen was regulated in the same manner as L-selectin and EL-246 recognized anti-L-selectin mAb affinity-purified antigen in SDS/PAGE Western blot analysis.

leukocyte EL-246 antigen

L-selectin

anti-L-selectin mAb


Input: A proposed method.


Input: The two SH3 domains are separated by a 54 amino acid linker region, whose length is highly conserved in xenopus, chicken, and mamalian Crk II proteins.

SH3 domains

mamalian Crk II proteins


Input: A clinical trial of a new mitomycin C derivative, KW-2083 (7-N-(p-hydroxyphenyl)-mitomycin C)


Input: In patients with active TB, cytokines that were elevated in serum were IFN-gamma, IL-6 and IL-10.

IFN-gamma


Input: Overexpression of p50 in transient cotransfection studies using the proximal CRP promoter (-125/+ 9) linked to a luciferase reporter caused a 3-fold increase of luciferase activity, while C/EBPbeta overexpression caused an 18-fold increase; simultaneous overexpression of both transcription factors increased luciferase activity approximately 600-fold.

CRP promoter

luciferase reporter

luciferase

C/EBPbeta

luciferase


Input: Complexities in the host-pathogen interactions during actual infection with Gram-negative bacteria may account for the difficulties in demonstrating this phenomena in vivo.


Input: PKCI-1 is a member of the HIT family of proteins, shown by sequence identity to be conserved in a broad range of organisms including mycoplasma, plants, and humans.

HIT family


Input: 6, 320 cells/mm3, respectively; P less than. 005); twelve (86%) of the 14 inmates who developed AIDS had counts of less than 5, 000 cells/mm3, compared with only six (14%) of the 42 controls (P less than. 00001).


Input: Hpr1 forms, together with Tho2, Mft1, and Thp2, the THO complex, which controls transcription elongation and genome stability in Saccharomyces cerevisiae.

THO complex


Input: A new model for objective assessment of cervical ripening: the effect of prostaglandin E2 and prelabor contractility.


Input: Insulin-secreting islet-cell tumours of the pancreas.

Insulin


Input: Suprapubic and intravesical methods


Input: Previous work established that the TAL1 proteins are phosphorylated exclusively on serine and identified Ser122 as a substrate for the mitogen-activated protein kinase ERK-1.

TAL1 proteins

mitogen-activated protein kinase ERK-1


Input: The use of ALAD activity and EP as cumulative lead exposure indicators is suggested.

ALAD


Input: Immunofluorescence obtained using antibodies against alphaI SigmaI/+ + betaI SigmaI spectrin and Abl tyrosine kinase but not against alphaII/betaII spectrin colocalized with the overexpressed green fluorescent protein-SH3-binding protein.

alphaI SigmaI/+ + betaI SigmaI spectrin

Abl tyrosine kinase

alphaII/betaII spectrin

green fluorescent protein

SH3-binding protein


Input: CONCLUSIONS: The present study showed it is possible to use a modified Stroop task as a measure of implicit processing of alcohol stimuli.


Input: Furthermore, the rapid light-mediated increase of CPRF proteins was insensitive to transcriptional inhibitors, suggesting that a post-transcriptional mechanism controls CPRF accumulation.

CPRF proteins

CPRF


Input: 43%, 6/14; P = 0. 013), whereas, in RCC samples with VHL methylation or mutation, the frequency of 3p14-p21 LOH did not differ from that of sp25-p26 (72%, 18/25 vs.

VHL


Input: One patient had chronic dysphoria and one encephalopatia toxica.


Input: A single clone, which was conserved and had near-perfect homology to eight human/rodent expressed sequence tags, was used as template for 5' and 3' rapid amplification of cDNA ends and SPICE (system for polymerase chain reaction amplification of cDNA ends) reactions to obtain the 3. 6-kb cDNA, LGL2 (Genbank, AF 110195) encoding a deduced polypeptide (lgl2) of 963 amino acids.

Genbank, AF 110195


Input: Effect of dimethyl sulfoxide on cooling rates of unrestrained rats.


Input: The GIS software program, ArcView, was used for spatial analysis and distance calculations. chi2 Tests were used to compare the distribution of the characteristics between intersection and midblock collisions.


Input: We have analyzed the role of the HU protein in invertasome assembly when the enhancer is located at variable positions close to one of the recombination sites.

HU protein


Input: We compared these responses for six hatchling and eight adult Chrysemys picta from an Ohio population.


Input: The likelihood of death was more than 3 times higher among patients in the ERA-II group (mortality risk ratio 3. 82 [95% CI 1. 48% to 9. 84], p = 0. 006).


Input: Pros and cons of selective inhibition of cyclooxygenase-2 versus dual lipoxygenase/cyclooxygenase inhibition: is two better than one?

lipoxygenase

cyclooxygenase


Input: INTERNET is literally a world of data, dialogue, and discourse on any topic imaginable, right at your fingertips.


Input: Here we show that the nucleotide in the middle of the anticodon (i. e., psi 35) also contributes to the suppressor efficiency displayed by cytoplasmic tRNA (Tyr).

cytoplasmic tRNA (Tyr)


Input: We established that, in unstimulated lymphocytes, the Src homology 2 (SH2) and SH3 domain-containing protein Grb2 and the p85 subunit of phosphatidylinositol 3-kinase, associate constitutively with Cbl via their SH3 domains.

Src homology 2

SH3 domain-containing protein Grb2

phosphatidylinositol 3-kinase

Cbl

SH3 domains


Input: In addition, Fc epsilon R1 cross-linking activates PI 3-kinase.

Fc epsilon R1

PI 3-kinase


Input: Similarly, an increase in CAT expression from the same construct (pBLCAT-ENDOA) was also observed in 7AQS2. 1 cells.

CAT

ENDOA


Input: Indirect determination of maximal O2 consumption in man.


Input: The two complexes were detected with a similar activation kinetics upon IL-4 stimulation.


Input: Although the occurrence of any ventricular ectopic activity, as detected by either or both methods, was common, the incidence was significantly higher (P less than 0. 001) in patients with coronary heart disease (86 percent; 77/90), as compared to that in normal subjects (40 percent; 12/30).


Input: The frequency of eating dark-meat fish was positively associated with serum eicosapentaenoic acid and docosahexaenoic acid, omega3 fatty acids, and inversely associated with serum stearic acid and linoleic acid.


Input: These 8-oxoguanine DNA glycosylases, hOgg1 (human) and mOgg1 (murine), are homologous to each other and to yeast Ogg1.

8-oxoguanine DNA glycosylases

yeast Ogg1


Input: HDE was found to be exclusively targeted to and imported into peroxisomes in both heterologous expression systems.

HDE


Input: Taken together, these results indicate that ICSBP and PU. 1 are critical elements for IL-18 gene expression.

ICSBP

PU. 1

IL-18 gene


Input: Model experiments on pheasants using single doses of the insecticide (Lindane) the herbicide (Terbutryn) a mineral fertilizer (calcium ammonium nitrate) and the fungicide (HCB).


Input: The main side-effects were myelosuppression, mucositis and peripheral neuropathy, which were all common and often severe.


Input: The decision support system uses the network at its core and helps not only in reaching a diagnosis but also in finding the optimal way to reach that diagnosis.


Input: Metapsychiatry is a term born of necessity to designate the important but hitherto unclassified interface between psychiatry and mysticism.


Input: Repression was strictly dependent on the presence of upstream Oshox1 binding sites in the reporter gene constructs and a function of the N-terminal region of Oshox1, preceding the homeodomain.

homeodomain


Input: Experimental studies and clinical application of plasma ACTH radioimmunoassay kit without extraction process

plasma ACTH


Input: Defects in RT6 expression coincide with increased susceptibility in animal models for insulin-dependent diabetes mellitus and other autoimmune diseases.

insulin


Input: By cloning genes encoding benzene-degradative enzymes, we found that strain JS150 also carries genes for a toluene/benzene-2-monooxygenase.


Input: Thus G17 targets the c-fos promoter CArG sequence via Rho A-dependent pathways, and Rho A appears to play an important role in the regulation of the trophic action of G17.

c-fos promoter CArG sequence

Rho A

Rho A


Input: By contrast with ama-1, rpc-1 was not deleted by mDf4 or larger deficiencies examined, indicating that these genes are no closer than 150 kb.


Input: Expression of the bacteriophage T4 DNA terminase genes 16 and 17 yields multiple proteins.

bacteriophage T4 DNA terminase genes 16 and 17


Input: Rat p8 mRNA was discovered because of its strong activation in pancreas during the acute phase of pancreatitis.

Rat p8 mRNA


Input: Dual signal peptides mediate the signal recognition particle/Sec-independent insertion of a thylakoid membrane polyprotein, PsbY.

signal recognition particle

Sec

PsbY


Input: Sequence divergence of approximately 16% reduced transformation frequencies by at least 10-fold.


Input: During subsequent CS-alone trials, the responses of (+) MK-801-injected mice were extinguished as easily as those of saline-injected mice.


Input: The three respective time control groups (C5, C10, and C15) were injected with saline solution.


Input: Next, to examine the regulation mechanism of CD44/ERM interaction in vivo, we reexamined the immunoprecipitated CD44/ERM complex from BHK cells and found that it contains Rho-GDP dissociation inhibitor (GDI), a regulator of Rho GTPase.

ERM

ERM

Rho-GDP dissociation inhibitor

GDI

Rho GTPase


Input: Ten patients (aged 28-76 years) with a terminal jejunostomy located within the first meter of jejunum were treated by infusion of an elemental diet into the distal small bowel (IEDDSB).


Input: The illuminator uses a grain-of-wheat light bulb and an adjustable bulb holder fashioned from bent paper clips.


Input: The goals of these experiments were to determine whether lactational anestrus would be prolonged by a 48-h fast at days 13 and 14 postpartum (pp) and, if so, to determine whether this effect could be reversed by treatment with the Ob protein leptin.

Ob protein leptin


Input: The kinetics of [14C] NG in the blood of the dosed animals was followed.


Input: RESULTS: In patients with necrotising fasciitis the arterial PO2 rose about 7-fold whereas the arterial PCO2 increased only slightly during exposure to 2. 5 absolute atmospheres (ATA) of oxygen.


Input: Coronary arteriographies and ventriculographies corresponding to 274 consecutive patients (January, 1975-October, 1978) with significant coronary lesions are reviewed.


Input: The data show that processing time as a function of intensity is modified not only at the retina but also at later processing sites.


Input: Lag phases were 14. 89 hours +/-0. 77, 13. 33 hours +/-0. 50, 20. 22 hours +/-0. 76, and 20. 00 hours +/-0. 79, respectively, for endothelial cell-induced LDL oxidation.

LDL


Input: Therefore, the Ogg1 protein is a eukaryotic DNA glycosylase/AP lyase.

Ogg1 protein

DNA glycosylase

AP lyase


Input: Being implicated in insulin and GK gene regulations as a common transcription factor, IPF1/STF-1/PDX-1 is likely to play an essential role in maintaining normal beta-cell functions.

insulin

GK gene


Input: MATERIAL AND METHODS:


Input: Salt wars.


Input: Finally, synthetic peptides corresponding to the mutant proteins were assessed for the ability to act as substrates for PR.

PR


Input: As an approach to the determination of structure-function relationships in the PRP4 protein, we have isolated more than fifty new alleles of the PRP4 gene through random and site-directed mutagenesis, and have analyzed the phenotypes of many of them.

PRP4 protein

PRP4 gene


Input: Brainstem auditory evoked potential responses (BAEPs) were recorded from CZ-A1 and CZ-A2 scalp regions in 23 hypertensive and 14 normotensive subjects.


Input: Although the Gly252Arg substitution observed in UM: JG5 is non-conservative, it was not possible to distinguish whether it is a mutation or a polymorphism.


Input: Two SH2 domains of p120 Ras GTPase-activating protein bind synergistically to tyrosine phosphorylated p190 Rho GTPase-activating protein. p120 GTPase-activating protein (GAP) is a negative regulator of Ras that functions at a key relay point in signal transduction pathways that control cell proliferation.

SH2 domains

p120 Ras GTPase-activating protein

GTPase-activating protein

p120 GTPase-activating protein

GAP

Ras


Input: Phosphorylation of the ras GTPase-activating protein (GAP) by the p93c-fes protein-tyrosine kinase in vitro and formation of GAP-fes complexes via an SH2 domain-dependent mechanism.

ras GTPase-activating protein

GAP

p93c-fes protein-tyrosine kinase

GAP

fes


Input: This resulted in a shift of C1/C2, so that the effect of collagen was more pronounced (maximal increase of C1/C2 = 134%) than ADP (maximal increase of C1/C2 = 79%).

collagen


Input: A significant increase of gastric mucosal permeability was observed in six normal human subjects after instillation of ethanol (20 percent v/v).


Input: Analysis of domain deletion mutants demonstrated strong synergy between the RRM and a central degenerate RRM repeat in binding to RNA.


Input: Overexpression of eIF4E transforms cells, and mutations in eIF4E arrest cells in G, in cdc33 mutants.

cdc33 mutants


Input: ZF87 specifically binds the ME1a1 element with higher affinity than the ME1a2 element.


Input: The unusual properties of TRAC activity and its relationship, if any, with the enigmatic Ku protein, are discussed.

TRAC

Ku protein


Input: Structure of the connective stroma of the epididymis in the zebu


Input: Characterization of regions of fibronectin besides the arginine-glycine-aspartic acid sequence required for adhesive function of the cell-binding domain using site-directed mutagenesis.

fibronectin


Input: These data suggest that multiple genetic recombination among bacteriophages with different immunities took place to generate the prophage VT1-Sakai.


Input: Transient-expression assay analysis of subclones of pPstI-G localized the trans-active factor to a 3. 0-kilobase XbaI fragment.

3. 0-kilobase XbaI fragment


Input: We used an immobilized template-based assay to examine transcription termination by VA1, 7SL, and Alu class III templates and the role of transcript release in the pol III terminator-dependent inhibition of processing of B1-Alu transcripts.

Alu class III

pol III

Alu


Input: Concentrations of platelet nitrite and total nitrate/nitrite were determined using simple and sensitive nitrate/nitrite fluorometric assay techniques.


Input: Using a GTP-dependent, brefeldin A-sensitive in vitro AP-1 binding assay, we have determined here the parameters of the AP-1 binding reaction.


Input: By using methanol-0. 15 M borate buffer of pH 8. 0, cate-chol-O-methyltransferase activity might be assayed.

cate-chol-O-methyltransferase


Input: Replacement of Val20-Leu21 with Ala-Ala produced a dimeric RII beta protein that binds AKAP75 approximately 4% as avidly as wild-type RII beta.

dimeric RII beta protein

wild-type RII beta


Input: Plasmodium vivax malaria.


Input: Postcontrast images were also acquired in the sagittal (six patients) and coronal (three patients) planes.


Input: Conservation of this zinc finger motif from yeast to mouse and human implies functional importance.


Input: In vitro death assays with transient overexpression of deletion constructs of both isoforms using beta-galactosidase as a reporter gene in MCF7 cells suggest the following: 1) the nucleotide binding domain may act as a negative regulator of the killing activity of DEFCAP; 2) the LRR/CARD represents a putative constitutively active inducer of apoptosis; 3) the killing activity of LRR/CARD is inhibitable by benzyloxycarbonyl-Val-Ala-Asp (OMe)-fluoromethyl ketone and to a lesser extent by Asp-Glu-Val-Asp (OMe)-fluoromethyl ketone; and 4) the CARD is critical for killing activity of DEFCAP.

beta-galactosidase

DEFCAP

LRR

CARD

LRR

CARD

CARD

DEFCAP


Input: Here, we provide direct evidence that the meiotic defect caused by either unregulated cAPK activity or unregulated ran1 + kinase activity is due to inability to induce transcription of the mei2 + gene, which is required for meiotic initiation.

cAPK

ran1 + kinase

mei2 + gene


Input: Sailer, K.


Input: The terminal a sequence of the herpes simplex virus genome contains the promoter of a gene located in the repeat sequences of the L component.


Input: The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle.

Caenorhabditis elegans NK-2 class homeoprotein CEH-22


Input: As tat itself dramatically increases HIV-1 gene expression, it too is presumably regulated in the latent state, and may also be activated by mitogenic stimulation.

tat


Input: The CBS-1 gene was mapped to human chromosome 10p12 between markers WI-8535 and WI-4724, and is tightly linked to the two STRP markers of D10S1789 and D10S550.

CBS-1 gene


Input: We have previously described the partial purification of Ap4A hydrolase from S. pombe [Robinson, de la Pena and Barnes (1993) Biochim.

Ap4A hydrolase


Input: Both flavoproteins are active as AhpC reductases and mediate electron transfer, resulting in the NADH-dependent reduction of hydrogen peroxide and cumene hydroperoxide.

AhpC reductases


Input: Together, these results indicate that YTS1 is a bifunctional protein active in both splicing and protein synthesis.


Input: The first operon, orf1-tolQRA, is iron regulated throughout growth, but iron-regulated expression of tolB and oprL fusions occurs only in late log phase.

tolQRA

tolB

oprL fusions


Input: Thus, STK1 is most likely the human homologue of MO15.

human homologue of MO15


Input: The human IFI16 gene is a member of an interferon-inducible family of mouse and human genes closely linked on syntenic regions of chromosome 1.

human IFI16 gene

interferon


Input: Late results in the treatment of urotuberculosis


Input: Blood samples for determination of fibrinolytic activity and factor VIII in plasma were obtained before and immediately after the end of compression and application of a stocking, respectively.

factor VIII


Input: Exon A1a encodes most of the 5'-untranslated region.


Input: Methylation interference analysis established at single nucleotide resolution that purified recombinant Fos and Jun proteins bind in a sequence-specific manner to the AP-1 sites within the VDRE and OC box.

Fos

Jun proteins

AP-1 sites

OC box


Input: Also, PTx had no effect on shear-dependent activation of JNK.

PTx

JNK


Input: Cardiovascular effects in man of intravenous prizidilol hydrochloride (SK & F 92657); a new antihypertensive agent.


Input: The human p18 gene spans at least 7. 5 kb and is composed of three exons, two of which encode the p18 protein.

human p18 gene

p18 protein


Input: Partial characterization of the CCAAT box in the promoter of the hLGFBP-1 gene: interaction with negatively acting transcription factors in decidualized human endometrial stromal cells.

hLGFBP-1 gene


Input: Footprints on the HPV 18 enhancer show five protected regions with homologies to NF1, AP1 and EFII transcription factor binding motifs.

HPV 18 enhancer

EFII transcription factor binding motifs


Input: These cDNAs were found to be derived from the 3 "-untranslated region (3 "-UTR) of the methyl-CpG-binding protein 2 gene (MeCP2).

methyl-CpG-binding protein 2 gene


Input: A simple algorithm fitting the data for the moving 192Ir source is proposed.


Input: Univariate and multivariate analysis was used to calculate the 5-year survival probabilities with respect to the following variables: age (< or = 65, > 65), sex, depth of invasion (mucosal, submucosal) tumor location (upper, middle and lower third), gross appearance (type I, type II and type III), size (< or = 1. 5 cm, > 1. 5 cm), presence or absence of lymph node metastasis, histological type (intestinal, diffuse), extent of lymphadenectomy (limited or extended), and type of gastrectomy (total or distal subtotal).


Input: Preventing the heterosexual spread of HIV into this vulnerable population is a formidable public health challenge.


Input: Carotid body chemoreceptor activity as recorded from the petrosal ganglion in cats.


Input: The first decision in management is to consider cardioversion which can be achieved in suitable cases electrically, or pharmacologically with a class Ic antiarrhythmic drug like flecainide or propafenone.


Input: Several studies have demonstrated that the corticotropin-releasing factor test (CRF) is useful for the aetiological diagnosis of Cushing' s syndrome: in Cushing' s disease, as opposed to ectopic ACTH secretion syndrome, the hypothalamus-pituitary-adrenal (HPA) axis can still be stimulated by CRF.

corticotropin-releasing factor

CRF

ACTH

CRF


Input: The NF-kappaB/Rel transcription factors participate in the activation of immune system regulatory genes and viral early genes including the human immunodeficiency virus type 1 long terminal repeat.

NF-kappaB

Rel

viral early genes

human immunodeficiency virus type 1 long terminal repeat


Input: These three chromosomes share the transferrin gene (TF), the myosin light polypeptide 3 gene (MYL3), and the acylpeptide hydrolase gene (APEH).

transferrin gene

TF

myosin light polypeptide 3 gene

acylpeptide hydrolase gene

APEH


Input: The preference for third base codon in Y position prolines is U for the alpha 2 (VI) collagen as it is for the human fibrillar collagen genes.

alpha 2 (VI) collagen

human fibrillar collagen genes


Input: BK-induced translocation and overexpression of PKC isoforms as well as coexpression of inactive or constitutively active mutants of different PKC isozymes provided evidence for a role of the diacylglycerol-sensitive PKCs alpha and epsilon in BK signaling toward MAPK.

BK

PKC isoforms

PKC isozymes

PKCs alpha and epsilon

BK

MAPK


Input: The rate of decrease of PRA after REM onset closely approximates the most recent estimations of PRA half-life, which suggests that REM onset is associated with a virtual cessation in renin production.

renin


Input: The second (control) group was represented by cases diagnosed as HSIL by cytology.


Input: Clinical trial endpoints based on magnitude of reduction in HIV-1 RNA levels provide an important complement to endpoints based on percentage of patients achieving complete virologic suppression.


Input: The psi zeta gene has a nonsense mutation in exon 1 but has identical promoter sequence and RNA processing sites to the zeta gene, raising the possibility that both psi zeta and zeta are transcriptionally active.

psi zeta gene

zeta gene

psi zeta

zeta


Input: The expression of cor14b was strongly impaired in the barley albino mutant an, suggesting the involvement of a plastidial factor in the control of gene expression.


Input: Pulse monitors in outpatient dental anaesthesia.


Input: Synthesis of 2-(2'-thiazolyl) alkanebenzimidazoles--potential anthelmintics


Input: Wild type MEKK1 enhances promoter activity and the activity can be inhibited by dominant negative MEKK1, MEK1, MEK7, MEK3, p38/RK, and c-Jun.

RK

c-Jun


Input: Tax and the active Tax mutants were able to abrogate the G1 arrest and apoptosis induced by p53, and this effect does not correlate with an altered localization of nuclear p53 or with the disruption of p53-DNA complexes.

Tax

Tax mutants

nuclear p53

p53-DNA complexes


Input: Chronic, recurrent multifocal osteomyelitis.


Input: Our current study aims at clarifying the role of myristoylation in caveolar targeting using well-characterized acylation mutants of two model proteins, namely Gi1 alpha and c-Src.

Gi1 alpha

c-Src


Input: Single substitutions of three highly conserved phenylalanine residues (Phe-15, Phe-17, Phe-27) by alanine and substitution of one histidine (His-29) by glutamine, all located within the putative RNA-binding sites RNP-1 and RNP-2, abolished the nucleic acid-binding activity of CspB.

CspB


Input: The lack of heterozygous positions essentially facilitates on the one hand the data analysis and on the other hand the detection of new alleles.


Input: BACKGROUND: The extract of medicinal plants containing curcumin is traditionally believed to have a positive contraction effect on the human gall-bladder.


Input: Moreover, the formation of the complex between IclR and the operator/promoter region has been found to be impaired by phosphoenol pyruvate but insensitive to acetate, acetyl-CoA, pyruvate, and oxaloacetate.

IclR


Input: Immunoprecipitation of spinophilin or neurabin from crude brain extracts selectively coprecipitated PP1gamma (1) over PP1beta.

spinophilin

neurabin

PP1gamma (1)


Input: Most important, after all, is not the ionization technique but the stage with a 47. 1% five-year survival rate in T1N0 as compared to T2N0 with 28. 6% and T1N1 with 19. 4%.


Input: The encoded Arabidopsis U3 snRNAs can be folded into a secondary structure which is more similar to that of U3 RNAs from lower eukaryotes rather than from metazoa.

Arabidopsis U3 snRNAs

U3 RNAs


Input: Cytokinetics of the Krebs 2 carcinoma.


Input: We investigated whether two WT1 splice variants lacking or including a three-amino-acid (KTS) insertion between the third and fourth zinc finger in the DNA-binding domain could repress the IR promoter in vitro.

WT1 splice variants

IR promoter


Input: These back mutations led to a modest decrease in kinase activity, decreased tumorigenic potential in chickens, and an unexpected increase in transforming activity in rat cells.


Input: Extragonadal endodermal sinus tumors in the head and neck are very rare.


Input: Plasma NE and E increased to significantly higher values after 15 min in the young subjects: 1. 68 +/-0. 18 vs.


Input: Utility of thallium-201 scintigraphy in detecting right ventricular dysfunction in pulmonary embolism.


Input: E. granulosus infection has been confirmed in 25 patients (20. 6%), in 16 cases by finding parasite protoscoleces or hooks and in nine cases by detection of an antigen specific for E. granulosus, antigen 5 (Ag5).

E. granulosus, antigen 5


Input: Transcription of FN promoter-chloramphenicol acetyltransferase fusion genes carrying the base substitution in one or more of these G-rich sequences both in vivo and in vitro revealed that the base substitution in any G-rich sequence results in reduction of promoter activity, although the downstream GC box (GCd) plays a primary role.

FN promoter

chloramphenicol acetyltransferase


Input: Teboroxime is a new boronic acid adduct of technetium dioxime (BATO) compound that demonstrates favorable characteristics in preliminary studies.


Input: We tested several growth regulatory genes that are repressed in senescent cells for ability to restore activity to T [K1].

T [K1]


Input: It is our conclusion that Sonoclot coagulation analysis is unlikely to identify patients with prolonged bleeding time in whom platelet count and other coagulation factors are normal.


Input: The single copy flotillin-1 gene is located at 6p21. 3 in the MHC class I region and consists of 13 exons over 15 kb.

flotillin-1 gene

MHC class I region


Input: Low plasma glucose concentrations that may or may not be sufficiently low to result in symptoms can be observed as a concomitant of several diverse diseases.


Input: However, patients with DPX should be observed for the potential occurrence of an associated condition.


Input: The effects of castor oil, alone, as well as in combination with PGI2 and indomethacin on gastrointestinal functions have been examined in rats.


Input: Effect of TNF, IL-1, and IL-6 on the proliferation of human Tenon' s capsule fibroblasts in tissue culture.

TNF


Input: Previous analysis of this motif in the lactose permease (A.

lactose permease


Input: Also, the RVW hypertrophy, the IVS hypertrophy, and the RV high pressure load to the LV through the IVS may be related to the small LV, high EF, and abnormal two chamber inflow in the PS group before BV.


Input: Several reports assert that prolactin affects the delta 5 and delta 4 pathways through its effect on the activity of 3beta-hydroxysteroid dehydrogenase (3beta-OHSD).

prolactin

3beta-hydroxysteroid dehydrogenase


Input: Acidosis provoked by 30% CO2 irreversibly increased the BDRT, however the TRT were not changed.


Input: In each study group, elevated levels of serum I were observed.


Input: A decrease was also found of the levels of total cholesterol and LDL-cholesterol.

LDL-cholesterol


Input: Sequencing of this fragment showed that the MRP13 coding region specifies a 324-amino-acid basic protein with a calculated Mr of 37, 366.


Input: Low serum C3 values were observed in all 11 children at some stage of their illness.

serum C3


Input: In spite of the presence of a physician, the real pathology of an indian population of Colombie is not very well known.


Input: During chordotonal organ development, the 3' enhancer directs expression in proneural clusters; whereas successive modular enhancers located in the 5' region drive tissue-specific expression in chordotonal organ precursors in the embryo and larval leg, wing and antennal imaginal discs.


Input: Is conventional sperm analysis of any use? The computerised records of 867 couples were used to investigate the prognostic significance of semen volume, motility, density and morphology.


Input: The effect of guaiphenesin on absorption and bioavailability of paracetamol from composite analgesic preparations.


Input: Detailed comparison of the urinary excretion of purines in a patient with the Lesch-Nyhan syndrome and a control subject.


Input: Antisense oligonucleotides complementary to the 5' end of PKC-zeta mRNA sequences significantly reduced the collagen lattice-stimulated alpha2 and MMP-1 mRNA levels.

PKC-zeta mRNA sequences

collagen

MMP-1 mRNA


Input: Furthermore, ERK phosphorylation was substantially prolonged in LC/BRY-treated cells compared to those exposed to BRY alone, and pretreatment with the highly specific MEK inhibitors, PD98059, U0126, and SL327, opposed ERK activation while protecting cells from LC/BRY-induced lethality.

ERK

MEK

ERK


Input: The most valid method was the AXB bearing with the cephalometric clinical diagnosis a 90. 91% concordance.


Input: However, coligation of Fc gamma RIIB1 with B cell Ag receptors (BCR) inhibits BCR-mediated signaling by a mechanism that may involve recruitment of phosphatases SHP-1, SHP-2, and the SH2 containing inositol 5' phosphatase (SHIP) to the phosphorylated Fc gamma RIIB1 immunoreceptor tyrosine-based inhibitory motif.

Fc gamma RIIB1

B cell Ag receptors

BCR

BCR

phosphatases SHP-1

SH2 containing inositol 5' phosphatase

SHIP

Fc gamma RIIB1 immunoreceptor tyrosine-based inhibitory motif


Input: At the first phase (1-43 ms for the VMN and 1-10 ms for the LN) the hypothalamic-cortical responses completely inhibited the formation of the VC response to the light stimulus.


Input: The slope of QD versus QEMF for the four tubes was near unity.


Input: The sequence of the 127 residue NrfF polypeptide, M (r) 14, 522, is strikingly similar to the CcI2 protein of R. capsulatus, especially in the putative haem-binding motif, RCPQCQNQN. (ABSTRACT TRUNCATED AT 400 WORDS)

127 residue NrfF polypeptide, M (r) 14, 522

CcI2 protein


Input: When cotransfected with the HIV LTR CAT into CV-1 cells, both the pCD41 and pGD41 clones trans-activated the HIV LTR.

HIV LTR CAT

HIV LTR


Input: From this comparison of aa sequences, the ATPK7 protein is considered to be a member of a novel subfamily of Ser/Thr PKs in plants.

ATPK7 protein

Ser/Thr PKs


Input: It is very probable that this change was due to mechanical effects induced by injecting a hypertonic solution of MT-141 at a rate of 70--130 ml/dog.


Input: Both viruses express the mil/raf oncogene product as a gag-fusion polyprotein, while the myc oncogene of MH2 is expressed via a subgenomic mRNA.

mil

raf

gag-fusion

myc


Input: Furthermore the aldosterone stimulating effect of low sodium diet (17 children), severe and prolonged vomiting (19 children) and synthetic ACTH (10 children) has been studied by our modified method.

ACTH


Input: Transmural metabolic heterogeneity at high cardiac work states.


Input: A flow probe for direct measurement of blood flow of the mitral valve was devised.


Input: The adoption of a twisted structure of importin-beta is essential for the protein-protein interaction required for nuclear transport.

importin-beta


Input: Liver disease and HCV infection after transplantation of organs from hepatitis C antibody positive donors.

hepatitis C antibody


Input: To investigate whether the two RPG-boxes mediate transcription activation of both the L46 and S24 gene, two experimental strategies were followed: cloning of the respective genes on multicopy vectors and construction of fusion genes.

RPG-boxes

S24 gene


Input: Electrophoretic mobility shift assays demonstrated that sequences within this region bind members of the Sp1 family of transcription factors.

Sp1 family of transcription factors


Input: The prevalence of antibodies to HRES-1 peptides pep14-24 and pep117-127 was determined in 65 normal blood donors and 146 patients with immunological disorders.

HRES-1 peptides pep14-24 and pep117-127


Input: SCOF-1 localized to the nucleus but did not bind directly to either C-repeat/dehydration (CRT/DRE) or ABA responsive element (ABRE), cis-acting DNA regulatory elements present in COR gene promoters.

COR gene promoters


Input: To date, 6 mammalian GRKs have been identified by molecular cloning.

GRKs


Input: OBJECTIVE: To report a case of fulminant neuropathy with severe quadriparesis associated with vincristine chemotherapy.


Input: The 1. 5-Mb region was covered by 137 cosmids with a minimum overlap set of 52 cosmids assigned to 17 bins and 9 contigs.


Input: Homodimers of RIP60 (replication initiation-region protein 60 kDA) purified from nuclear extract bind two ATT-rich sites in oribeta and foster the formation of a twisted 720 bp DNA loop in vitro.

replication initiation-region protein 60 kDA


Input: Effect of age on glucose, reducing sugars and plasma insulin in blood of milk-fed calves.

plasma insulin


Input: Principal component analysis using psychosocial factors in women showed two psychosocial structures, i. e. the second principal (high SOC, high lifestyle, and low stress) and the 4th principal components (high supernatural HLC, and high PHLC).


Input: In response to acoustical stimulation the properties of response latency, discharge pattern, frequency tuning, binaural interaction, and habituation were examined to allow an appraisal of the differentiation of the MGB by electrophysiological means.


Input: These two enhancer elements also enhanced transcription when fused separately to the basal promoter region of the chicken vimentin gene.

chicken vimentin gene


Input: Availability of a less palatable diet (chow) following presentation of palatable diets will not result in diminished caloric intake, body weight, obesity and hyperinsulinemia.


Input: Residues of Stauffer R-3828 and its oxygen analogue in the body tissues of cattle fed R-3828 in the diet.


Input: Type II neuroleptanalgesia in odonto-stomatology


Input: In addition, there was an increase in the amount of p120 Ras-specific GTPase-activating protein (GAP) and GAP-associated p190.

p120 Ras

GTPase-activating protein

GAP

GAP


Input: OBJECTIVE: Respiratory-related electromyographic (EMG) activity of the superior pharyngeal constrictor (SPC) muscle was analyzed during the early stage of forced breathing.


Input: Glutathione reductase activities in liver, kidney, lung, and brain were not affected by diet.

Glutathione reductase


Input: LIP and DIP are less common IIPs, both characterized by ground-glass attenuation.


Input: Healthy subjects received the following regimens, dosed to steady state: trovafloxacin 300 mg/24 h; ciprofloxacin 400 mg/12 h; trovafloxacin 300 mg/24 h plus cefepime 2 g/12 h, and ciprofloxacin 400 mg/12 h plus cefepime 2 g/12 h.


Input: The data obtained with cellular RNA from HepG2 cells demonstrated that transcription is initiated 891 bases upstream of the translation-start site and that the polyadenylation site is located 550 bases downstream of the stop codon.


Input: To investigate possible roles for HCP during late erythroid differentiation, effects of manipulating HCP expression or recruitment on EPO-induced hemoglobinization in erythroleukemic SKT6 cells have been investigated.

HCP

HCP

EPO


Input: To investigate the role of bHLH proteins in MC3T3-E1 osteoblasts, which undergo a developmental sequence in vitro, we analyzed the transcriptional control of osteocalcin gene expression by stable transfection of an osteocalcin promoter-luciferase chimeric gene (p637OC-luc) and assessed the role of E-box cis-acting elements in osteocalcin promoter by DNA binding assays.

bHLH proteins

osteocalcin gene

osteocalcin promoter

luciferase

osteocalcin promoter


Input: Genetic linkage mapping of the CYP11A1 gene encoding the cholesterol side-chain cleavage P450scc close to the CYP1A1 gene and D15S204 in the chromosome 15q22. 33-q23 region.

CYP11A1 gene

CYP1A1 gene


Input: Expression, characterization, and genomic structure of carp JAK1 kinase gene.

carp JAK1 kinase gene


Input: Jornvall, B.


Input: Copyright 1998 Academic Press.


Input: Three modern hematology analyzers (Abbott Cell-Dyn 3000, Coulter STKS, and Sysmex NE-8000) with high throughput and 5-part differential capability were evaluated using a protocol designed by a quality team.


Input: Effect of prostaglandin E2 on experimental atherosclerosis.


Input: The tro operon is flanked by a Holliday structure DNA helicase homolog (upstream) and two ORFs representing a purine nucleoside phosphorylase homolog and tpp15, a previously characterized gene encoding a membrane lipoprotein (downstream).

tro operon

Holliday structure DNA helicase

purine nucleoside phosphorylase


Input: However, a few sites in the genomes of EC cells permit M-MuLVneo delta Enh proviral expression.

M-MuLVneo delta Enh


Input: We have been developing a digital fluoroscopic imaging system to replace the portal films that are currently used to verify patient positioning during radiotherapy treatments.


Input: We have utilized transient transfections, mutation analysis, electromobility gel-shifts, and immunoblot analysis to test the hypothesis that expression of the CTalpha gene is controlled in part by the binding of three trans-acting nuclear factors, Sp1, Sp2, and Sp3.

CTalpha gene


Input: Determinants of recurrent ischaemia and revascularisation procedures after thrombolysis with recombinant tissue plasminogen activator in primary coronary occlusion.

tissue plasminogen activator


Input: Interestingly, unlike PAK65, HPK1 does not contain the small GTPase Rac1/Cdc42-binding domain and does not bind to either Rac1 or Cdc42, suggesting that HPK1. activation is Rac1/Cdc42-independent.

small GTPase Rac1


Input: Transformations with circular plasmids yielded slowly and irregularly growing geneticin-resistant mycelia in which 1% of nuclei contained plasmid sequences.


Input: Using a combined pharmacokinetic-pharmacodynamic model, the impact of various factors on the effective bioavailability and on its estimation, using the intravenous-to-oral dose ratio required to produce the same area under the response time curve after acute administration, are explored.


Input: We found that in anesthetized, paralyzed cats, the visual evoked potential (VEP) was dependent only on magnitude of delta C at each pattern transition, and was independent of the starting or ending contrast level.


Input: Plasmid pSP64E6E7 which contains the reading frames of both E6 and E7 was constructed in order to study the expression of both proteins in a coupled transcription/rabbit reticulocyte translation system.


Input: A 99m Tc bone scan showed a focal area of an increased uptake at the site of the mass below the calcaneus.


Input: In addition, FOP-FGFR1-expressing cells show constitutive phosphorylation of the positive regulator of translation p70S6 kinase; this phosphorylation is inhibited by PI3-kinase and mTOR (mammalian target of rapamycin) inhibitors.

FOP

p70S6 kinase

mTOR

mammalian target of rapamycin


Input: As a test of this hypothesis, we predicted that mice which have altered expression of class I gene products, the beta2-microglobulin knockout mice, [beta2m (-/-)], would develop Fe overload.

[beta2m (-/-)]


Input: The synthesis of endo-adduct [4aS, 5S, 8R, 8aR, SS]-9d resulting from cycloaddition on the substituted C (2)-C (3) double bond was achieved in a chemo-and diastereoselective way from quinone 1d in the presence of ZnBr (2).


Input: Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.

Max

c-myc


Input: Maximal Expiratory Flow Rates such as Peak Expiratory Flow Rate (PEFR), rates at 25%, 50% and 75% of forced vital capacity (V max 25%, V max 50% and V max 75%) and forced expiratory flow during the middle half of forced vital capacity (FEF 25-75%) were measured in 273 healthy non-smoking adults (144 males, 129 females) aged 15-63 years living in Madras.


Input: This polypeptide includes the first three zinc fingers of the TFIIIA DNA binding domain.

TFIIIA DNA binding domain


Input: Transcription of eukaryotic tRNA genes is dependent on the A-and B-Box internal control regions (ICRs) and the upstream transcription modulatory region.


Input: This dose of Na3 citrate produced no clinical symptoms suggestive of hypocalcaemia in these subjects, even though the use of acid-citrate-dextrose, NIH formula A (ACD-A) under identical conditions has been reported to reduce significantly the level of total calcium in serum, and concomitantly increase the number or reactions occurring in donors.


Input: Cough-CPR, a deep rhythmic forceful cough repeated 30-60 times per minute, can be an effective resuscitative technique during emergencies occurring in the cardiac catheterization laboratory.


Input: The gene encoding the Neisseria lactamica III DNA methyltransferase (M. NlaIII) which recognizes the sequence CATG has been cloned and expressed in Escherichia coli.

Neisseria lactamica III DNA methyltransferase

M. NlaIII


Input: A multivariant study of pituitary adenoma, obtainment of two logistic regression equations as an auxiliary support in the diagnosis of these tumors.


Input: Increased TRE DNA binding failed to lead to increased transactivation correlating with the inability of SB 203580 to increase phosphorylation of these AP-1 proteins.

AP-1 proteins


Input: APL patients showed a low, yet variable, level of JEM-1 mRNA in bone marrow.

JEM-1 mRNA


Input: The cDNA clones encode a polypeptide of 657 amino acids with a bHLH (basic-helix-loop-helix) domain, characteristic of a large family of transcription factors, and a PAS (Per-Arnt-Sim) domain in the amino-terminal half region.

PAS

Per

Arnt

Sim


Input: We propose that the cDNA encodes an apical plasma membrane protein that plays a role in the functional expression of the amiloride-sensitive epithelial sodium channel.


Input: Nedocromil sodium shifted the severity of the early allergic reaction (EAR) from mean-34. 8% to-6. 9% and inhibited the later allergic reaction (LAR) from-30. 5% to + 0. 4% (p less than 0. 005).


Input: Values of K1 and Vd were significantly increased in the tumour tissue.


Input: The binding of PTB was antagonistic to the binding of U2AF to the enhancer-located pyrimidine tract.

PTB


Input: Our results separate these factors into four regulatory classes: (i) constitutive factors, such as Oct-1 and probably Sp1, that are expressed in thymocytes at all stages; (ii) inducible factors, such as NF-kappa B and complexes binding to the region of a CD28 response element, that can be activated in all thymocytes, including those cells (CD4 + CD8 + TcRlow) that can undergo selection; (iii) inducible factors, such as NF-AT and AP-1, that can be activated in mature (CD4 + CD8-TcRhigh) and immature (CD4-CD8-TcR-) thymocytes alike but not in the transitional stages when the cells (CD4 + CD8 + TcRlow) are subject to selection; and (iv) a factor containing CREB, which can be activated in thymocytes of all developmental stages by culture but does not require specific induction.

NF-kappa B

CD28 response element

CD4 + CD8 + TcRlow

NF-AT

CD4 + CD8-TcRhigh

CD4 + CD8 + TcRlow

CREB


Input: Similar tissue-specific patterns are observed with a fusion between the caufliflower mosaic virus 35S RNA promotor and the GUS gene.

caufliflower mosaic virus 35S RNA promotor

GUS gene


Input: The results obtained show that expression of the gene is low at 23 degrees C and is induced rapidly at 37 degrees C.


Input: However, in each case in which either the DQ alpha-or DQ beta-chain was exchanged, major alterations or reversals of this pattern of interaction were observed.

DQ alpha-or DQ beta-chain


Input: Two methods for the routine determination of blood hemoglobin oxygen affinity are described.

hemoglobin


Input: The cause for the increase in plasma ANP levels in the active phase remains to be determined.

plasma ANP


Input: The effects on survival of adjuvant treatments, including pre-or postoperative systemic or postoperative intra-arterial chemotherapy, are currently under evaluation.


Input: Malformations of the regenerating optic tectum of larvae of the Egyptian toad, Bufo regularis Reuss.


Input: Immunological studies also failed to demonstrate any significant change except for a significant increase of natural killer (NK) cell activity after IFN-gamma infusion.

IFN-gamma


Input: We have used systemic application of the ototoxic drug amikacin, to induce total cochlear haircell loss in the chinchilla, in order to create an animal model of profound deafness.


Input: BACKGROUND--Platelet activating factor (PAF) has been implicated in the pathogenesis of airway hyperresponsiveness in asthma.

Platelet activating factor

PAF


Input: To be a nurse.


Input: Chronic granulocytic leukemia in children.


Input: Charcot joints.


Input: Recombinant apoA-I protein recovered from the soluble fraction of the bacterial cell pellet was purified to greater than 95% homogeneity by reversed-phase high-performance liquid chromatography.

Recombinant apoA-I protein


Input: Kaposi' s sarcoma-associated herpesvirus/human herpesvirus-8 ORF50 gene product contains a potent C-terminal activation domain which activates gene expression via a specific target sequence.


Input: Comparison of the 5' flanking regions of the mouse J kappa elements, including the conserved putative recombination target sequences, shows no obvious differences consistent with the variation in recombinational efficiency, so we conclude that, although the consensus heptamer and nonamer signals may be sufficient to identify a recombination site, the probability that that site will be used depends also on other determinants.

mouse J kappa elements


Input: Further interventions were: nephrectomy (2x), resection and ligation of the inferior vena cava (1x), resection and replacement of the left renal vein (1x).


Input: Herein, we report that CRE-decoy oligonucleotide treatment results in an increase in the p53 protein level in MCF-7 human breast cancer cells that express wild-type p53.

p53 protein


Input: Competition and methylation interference assays showed that the binding site for the novel factor was limited to nucleotides in the 3' half of the kappa B site.

kappa B site


Input: We have introduced the same change in a yeast tRNA (Trp) gene and demonstrated that the tRNA acts as an efficient amber suppressor in vivo.

yeast tRNA (Trp) gene


Input: Both proteins share sequence similarity with the myelin-associated glycoprotein, an adhesion molecule of oligodendrocytes and Schwann cells that has been implicated in the process of myelination, raising the important question of whether myelin-associated glycoprotein is also a sialic acid-binding protein.

myelin-associated glycoprotein

myelin-associated glycoprotein

sialic acid-binding protein


Input: The predicted 5' and 3' ends of the transcript are in very good agreement with the previously determined size of the LEU3 message.


Input: These clones contain most of the exon of cyclin D2 except exon 5.

cyclin D2


Input: By 24 h, there was no significant difference in FFA levels from shams.


Input: The clr1 locus regulates the expression of the cryptic mating-type loci of fission yeast.

clr1 locus

cryptic mating-type loci of fission yeast


Input: The odds of atopy (defined as a positive test for at least one of the antigens) were 5 times higher (odds ratio = 7. 0; 95% confidence interval = 1. 6-31. 1%; p = 0. 01) in the uninfected group, after taking into account the potential influence of gender and age.


Input: In mouse, two high-affinity binding sites with an apparent dissociation constant (Kd) of 50 to 100 nM have been mapped in the 5' ETS upstream from the early pre-rRNA processing site.

ETS


Input: As much thrombin was formed during cardiopulmonary bypass (measured by the prothrombin activation fragment F1 + 2 and thrombin-antithrombin complexes) as in normal patients, showing that factor XII was not necessary for thrombin generation.

thrombin

prothrombin activation fragment F1 + 2

thrombin

antithrombin

factor XII

thrombin


Input: This article reviews current concepts of pathophysiology and summarises clinical features, natural history and available treatments.


Input: Pendulin, a Drosophila protein with cell cycle-dependent nuclear localization, is required for normal cell proliferation.

Pendulin


Input: The phosphatase active site is located within residues 367-374.


Input: The central region of the sarcomere, coincident with the M line, was selectively labeled with antibodies to the short C-terminal form.


Input: Moreover, antibody binding to the same two determinants was also inhibited when ZAP-70 or the SH2 domains bound to the zeta chain or to a 2pY-ITAM.

SH2 domains


Input: Interleukin-1 increased the noradrenaline release.


Input: A representative group of patients undergoing open radical nephrectomy for clinical T1, T2 lesions was also identified.


Input: These findings indicate that KCTG can contribute to improved monitoring in high-risk pregnancies.


Input: These extrachromosomal copies can be isolated as covalently closed molecules with lengths around 3mu.


Input: Significant reductions were noted in vertical GRFs per newton of body weight exerted at 10% (P = 0. 0009) and 20% (P = 0. 0383) of stance phase and in anteroposterior GRFs exerted at 10% (P = 0. 0009) and 50% (P = 0. 0033) of stance phase when ambulation was compared with and without the orthotic device.


Input: Similar immunological disturbances were observed in SCI but not in the PC2 subgroup, i. e. patients examined later than 6 months after injury.


Input: Trimethylcolchicinic acid methyl ether d-tartrate (TMCA; NSC-36351) was administered daily by mouth to 71 patients with malignant lymphomas.


Input: After multivariate analysis, TWA correlated with age (P = 0. 02) and LV function (P = 0. 002) and occurred more often in patients after nonanterior MI (P = 0. 03).


Input: In rats exposed to Cd for 30 d, the levels of urinary excretion of cAMP after treatment with parathyroid hormone (PTH), parathyroidectomy (PTX), or 1 alpha-hydroxycholecalciferol (1 alpha-OH-D3) showed almost the same patterns as those of control rats: the response of urinary cAMP to treatment with PTH was not influenced by continuous oral administration of Cd.

parathyroid hormone

PTH

PTH


Input: Receptor-type serine/threonine kinases (RSKs) have been organized into two distinct classes known as types I and II on the basis of sequence similarity.

Receptor-type serine/threonine kinases

RSKs


Input: In the remaining 91 patients (group 2), Pseudomonas (18), coagulase-negative Staphylococci (15), Staphylococcus epidermidis (23), Staphylococcus aureus (16), Corynebacterium species (12), and others (seven) were isolated.

coagulase


Input: This cDNA corresponded to FGF-binding protein (FGF-BP), a secreted protein previously shown to bind acidic and basic FGF and to modulate their activities.

FGF-binding protein

FGF-BP

basic FGF


Input: Electrophoretic mobility-shift assays using oligonucleotides derived from these sites demonstrated formation of specific DNA-protein complexes.


Input: For the P transcript from phage with the G (-) orientation, full termination activity required both the region containing the stem-loop structure and upstream sequences.

P transcript


Input: One day after injection 48% of the injected activity was in the skeleton, 9. 3% in the liver, 3% in the kidneys and 4. 4% in the rest of the organs.


Input: Of these four PP2C genes, the expression of the PP2Cbeta gene has been reported to be tissue-specific and development-dependent.

PP2C genes

PP2Cbeta gene


Input: Combined chemotherapy with VM 26 and BCNU for recurrent malignant gliomas after operation and irradiation.


Input: Administration of FR 34235 reduced aortic blood pressure and increased cardiac output in anesthetized dogs with an ameroid-induced coronary artery occlusion.


Input: Alternative immune globulin preparation when standard immune serum globulin is not available.

immune globulin

immune serum globulin


Input: Two sibs with identical features of short-limbed dwarfism, a normal skull and face and normal intelligence are described.


Input: Effect of a high sugar intake on some metabolic and regulatory indicators in young men.


Input: In the second group the untreated fellow eye was microscopically intact, but was shown (as the treated eye) to alter the concentration of uronic acid in different parts of the sclera.


Input: Amplification of 4q21-q22 and the MXR gene in independently derived mitoxantrone-resistant cell lines.

MXR gene


Input: Expression of putative constitutively active forms of DdMEK1 in a ddmek1 null background is capable, at least partially, of complementing the small aggregate size defect and the ability to activate guanylyl cyclase.

guanylyl cyclase


Input: Quantitative Tl-201 analysis after stress has also shown viable myocardium in most mild to moderate (51% to 85% of normal uptake) irreversible Tl-201 defects.


Input: However, ADAR1 and the related deaminase ADAR2 showed significant expression in all regions of the brain examined, including cortex, hippocampus, olfactory bulb, and striatum, where the 5-HT2CR pre-mRNA was extensively edited.

deaminase ADAR2

5-HT2CR pre-mRNA


Input: Psychophysical evidence is given for the existence of two distinct systems in human vision: a fast, sign-invariant system concerned with extracting contours and a slower, sign-sensitive system concerned with assigning surface color.


Input: Five girls with Turner' s syndrome aged 12 to 17 years showed LH values (5. 0-14. 5 IU/12 h) at the upper end of or slightly above the normal range and pathologically high values (22. 2-43. 5 IU/12 h) for FSH.

LH

FSH


Input: Thirty-seven patients with severe temporal lobe epilepsy were studied interictally with [18F] fluorodeoxyglucose-PET in each of three conditions: resting, during emotional speech, and while performing a visual recognition task.


Input: The sequence of Vac1p contains two putative zinc-binding RING motifs, a zinc finger motif, and a coiled-coil motif.


Input: Serum concentrations of hormones in patients classified as C were characteristically and inclined to be hypergonadotropic and hypoestrogenic.


Input: Kinase renaturation tests designed to detect reactivated protein kinases after electrophoresis in sodium dodecyl sulfate-polyacrylamide gels revealed the presence of a 60-kDa kinase in the washed immunoprecipitate obtained from liver cytosol using anti-AHR antibody (IgG) and protein A/G/agarose beads but not when a nonspecific IgG was used instead of anti-AHR antibody.

anti-AHR antibody

IgG

IgG

anti-AHR antibody


Input: The immune response seems to be partially responsible for both protection and the destructive consequences of chlamydial infection.


Input: Activated FGFR3 predominantly interacts with GRB2. Sos in complex with a previously identified 90-kDa protein and designated protein 80K-H.

GRB2. Sos

protein 80K-H


Input: We generated " signature " oligonucleotides from these CDR3s and probed PCR amplified V kappa products from the synovium and PBLs of the same patient, and from PBLs and spleen of individuals without rheumatic disease.

V kappa products


Input: It was predicted that the Stroop task would trigger greater consumption of ice cream than a fearful film, and that this effect would be more pronounced for binge-eaters than non-binge-eaters.


Input: Patients with PLM show excessive daytime sleepiness or insomnia.


Input: Plasma colony-stimulating factor analysis and the clinical significance

Plasma colony-stimulating factor


Input: Structure and regulation of KGD2, the structural gene for yeast dihydrolipoyl transsuccinylase.

yeast dihydrolipoyl transsuccinylase


Input: We identified two potential phosphorylation sites at serine49 and serine133, both of which seem to be necessary for Myf-5 activity.


Input: Exposure of raft cultures to activators of protein kinase C, such as phorbol esters, results in the further induction of late gene expression as well as virion assembly.

protein kinase C

late gene


Input: Here we demonstrate that the T cell antigen receptor zeta-chain-associated ZAP-70 kinase and T cell antigen receptor zeta-chain immunoreceptor tyrosine-based activation motifs are essential for the membrane recruitment of SOS and Vav.

T cell antigen receptor zeta-chain-associated ZAP-70 kinase

T cell antigen receptor zeta-chain immunoreceptor tyrosine-based activation motifs

SOS

Vav


Input: Above this transition temperature the calcium antagonist lowers fm more pronouncedly than below.


Input: Behavioral effects of benzodiazepine ligands in non-dependent, diazepam-dependent and diazepam-withdrawn baboons.


Input: Gastrointestinal accumulation of indium-111 labelled granulocytes in reactive arthritis.


Input: TNF-alpha stimulated these changes in part by increasing transcription and stabilization of RNA for amphiregulin, an EGF receptor ligand, and amphiregulin directly increased HPV-16 E6/E7 and cyclin A RNAs.

TNF-alpha

amphiregulin

EGF receptor

amphiregulin

cyclin A RNAs


Input: The JNK/SAPK activator mixed lineage kinase 3 (MLK3) transforms NIH 3T3 cells in a MEK-dependent fashion.

JNK

SAPK

mixed lineage kinase 3

MEK


Input: Biochemical analyses revealed that the concentration of norepinephrine was reduced significantly in cortex-hippocampus and olfactory bulb but not in other regions, while dopamine and serotonin levels were not altered in any brain region examined.


Input: A mouth asymmetry study.


Input: Control oligomers of scrambled sequence but identical base composition were ineffective, and no TFO-induced recombination was seen in a control LTK (-) cell line carrying an otherwise identical dual TK gene construct lacking the 30-bp polypurine target site.

TK gene construct


Input: Transformation of chicken embryo fibroblasts (CEF) with the Gag-Crk fusion protein results in the elevation of tyrosine phosphorylation on specific cellular proteins with molecular weights of 130, 000, 110, 000, and 70, 000 (p130, p110, and p70, respectively), an event which has been correlated with cell transformation.

Gag

Crk


Input: Tilisolol and carboxymethylcellulose sodium salt (CMC) were used as the model ophthalmic drug and viscous polymer, respectively.


Input: OAT has become safer in recent years, particularly if monitored in special anticoagulation clinics.


Input: The results were compared with the findings in pair-fed non-treated animals (Control Group).


Input: Our data are in line with the hypothesis that E2F functions as a growth-and cell cycle regulated tethering factor between Sp1 and the basic transcription machinery.


Input: Fetal transplants rescue axial muscle representations in M1 cortex of neonatally transected rats that develop weight support.


Input: However, to encourage good contact between the farmers and the inseminating personnel, it is beneficial that herdsmen are present when cows are inseminated.


Input: Solution of the Boltzmann equation in a random magnetic field.


Input: These include the genes, undefined 1 (UD1), UD2, and UD3, each coding for proteins of unknown function, the ken gene encoding a new Kruppel-like putative transcription factor, the fly homologues of the mammalian mitochondrial trifunctional enzyme (thiolase), and the TAR DNA-binding protein-43 (TBPH), the first nonvertebrate member of the transmembrane 4 superfamily (TM4SF) gene, a new homeodomain gene, and a gene coding for a putative nuclear binding protein (PNBP) that is homologous to maleless, and a Copia-like element.

undefined 1

ken gene

Kruppel-like putative transcription factor

mammalian mitochondrial trifunctional enzyme

thiolase

TAR DNA-binding protein-43

TBPH

transmembrane 4 superfamily

homeodomain gene

maleless

Copia-like element


Input: It is recommended that area correction be attempted in bioequivalence studies of drugs where high intrasubject variability in clearance is known or suspected.


Input: A method for determining the toxicity of neutralizers for antimicrobial agents to A. castellanii was also evaluated.


Input: In the present study we use a tnaC-UGA-' lacZ construct lacking the tnaC-tnaA spacer region to analyze the effect of TnaC synthesis on the behavior of the ribosome that translates tnaC.

tnaC

' lacZ

tnaC

tnaA

TnaC

tnaC


Input: Unlike JNK activation, ERK activation could not be mapped to specific reovirus gene segments, suggesting that ERK activation and JNK activation are triggered by different events during virus-host cell interaction.

JNK

ERK

ERK

JNK


Input: Promoter region of the human alpha 2A adrenergic receptor gene.

human alpha 2A adrenergic receptor gene


Input: Analysis of deletion and substitution mutations in the MER2 5' exon demonstrates that the unusually large size of this exon plays an important role in splicing regulation.

MER2 5' exon


Input: Schottky-barrier heights of Ti and TiSi2 on n-type and p-type Si (100).


Input: In-111-BLMC uptake was directly proportional to Ki-67/MIB-1 activity and number of mitoses in tumor tissue.


Input: The majority of the human Ig heavy chain (IgH) constant (C) region locus has been cloned and mapped.

human Ig heavy chain (IgH) constant (C) region locus


Input: On guanidine and the treatment of botulism.


Input: Excellent results were recorded in 390 (83. 69%) of the patients, improvement in 46 (9. 87%) where in the majority a varicose complex was involved.


Input: By differential screening of a Xenopus laevis egg cDNA library, we have isolated a 2, 111 bp cDNA which corresponds to a maternal mRNA specifically deadenylated after fertilisation.


Input: Most of these elements are adjacent to type X telomeric repeats, and regions flanking four of five characterized S. paradoxus insertions carry autonomously replicating sequences.


Input: Mutational analysis of the putative effector domain of the GTP-binding Ypt1 protein in yeast suggests specific regulation by a novel GAP activity.

GTP-binding Ypt1 protein

GAP


Input: We recently described the isolation and characterization of nontoxic PAP mutants, NT123-2, which has a point mutation (E176V) in the active site that abolishes enzymatic activity, and NT124-3, which has a nonsense mutation that results in deletion of the C-terminal 25 aa (W237Stop).

PAP mutants


Input: This ligand-independent pathway can function through another androgen-regulated promoter as shown by the use of the mouse mammary tumor virus MMTV-CAT reporter.

mouse mammary tumor virus MMTV-CAT reporter


Input: From the present results a concept of hormone-dependent AR activation is proposed, which requires a functional, direct or indirect intramolecular interaction between the TAD and the LBD.

AR


Input: All patients were peritonitis-free at least 6 weeks before each PET.


Input: After control for body mass index, trait anxiety and anger-in remained independent predictors of diastolic blood pressure among the women.


Input: Studies on low-dose oral contraceptives: cervical mucus and plasma hormone changes in relation to circulating D-norgestrel and 17alpha ethynyl-estradiol concentrations.


Input: The predicted vav oncogene protein sequence exhibits several motifs reminiscent of transcriptional factors.

vav oncogene protein sequence


Input: The platelet membrane glycoprotein IIb/IIIa receptor inhibitor abciximab is used for the treatment of patients undergoing high-risk percutaneous coronary interventions and is used in approximately one third of coronary interventions in the United States and a growing number of procedures in Europe.

platelet membrane glycoprotein IIb/IIIa receptor


Input: The mean times to LNR in these groups were 42. 0 months (range, 3. 0-194. 5 months) and 49. 0 months (range, 3. 6-209. 0 months) respectively.


Input: Ultraviolet crosslinking experiments using element B revealed the specific binding of two proteins of approximately 43 and 80 kDa.


Input: The cells were densely ciliated, each cilium showing a typical 9 + 2 fibrilar pattern.


Input: Searching the human DNA data base of expressed sequence tags (EST) revealed novel partial sequences similar to, but distinct from, the sequences of the previously known PEF proteins.

PEF proteins


Input: HBO had marked effects on these enzymes: lung SOD increased (guinea pigs 47%, rats 88%) and CAT and GSHPx activities decreased (33%) in brain and lung.

lung SOD

CAT

GSHPx


Input: RXRalpha/RARalpha heterodimers and HNF-4 homodimers bind to DR-1 motifs on elements B and I4, respectively.

RXRalpha

RARalpha

HNF-4 homodimers


Input: Adenomas in the upper gastrointestinal tract were found in all of the patients: Vater' s papilla--12, duodenum--nine, and gastric antrum--seven.


Input: A new direct hemagglutination test (HI-GONAVIS) for urinary LH was compared with the serum radioimmuno-assay of LH.

LH

LH


Input: Sucrose produced in source leaves is the predominant carbon source for developing sink tissues in most higher plants.


Input: Accumulation of amines in the isolated perfused rabbit lung.


Input: They also show that M. malmoense can be isolated from the environment which may be the source of the infection.


Input: On the pharmacology of 9, 10-dihydro-10-(1-methyl-4-piperidylidene)-9-anthrol (WA 335), a histamine and serotonin antagonist


Input: This incompatibility phenotype requires the global transcriptional repressor, KorB, and the target for incC-mediated incompatibility is a KorB-binding site (O (B)).

KorB

incC

KorB-binding site (O (B))


Input: Therefore, a structural interaction between PsaL and PsaI may stabilize the association of PsaL with the photosystem I core.

PsaL

PsaI

PsaL

photosystem I core


Input: Binding of the TorR regulator to cis-acting direct repeats activates tor operon expression.

TorR regulator

tor operon


Input: Histological and immunophenotypic studies revealed 12 large cell lymphomas (11 B cell and one T cell), two small noncleaved cell lymphomas (B-cell phenotype), and five low grade B-cell lymphomas (two small lymphocytic and three follicular mixed lymphomas).


Input: The subjects were 17 patients with android obesity (four men and 13 women) aged 21 to 58 years with a body mass index (BMI) ranging from 32. 0 to 52. 2 kg/m2 and an abdominal-gluteal ratio greater than 1. 0.


Input: A mean value for HbA1 greater than 10% was associated with an increased risk of progression of retinopathy and a mean value less than 8. 7% was associated with a diminished risk.


Input: An emended diagnosis of Tylocephalum is proposed excluding this feature, along with distribution of the testes in the preovarian field and circummedullary distribution of vitelline follicles.


Input: Role of double-stranded RNA-dependent protein kinase in mediating hypersensitivity of Fanconi anemia complementation group C cells to interferon gamma, tumor necrosis factor-alpha, and double-stranded RNA.

double-stranded RNA-dependent protein kinase

interferon gamma

tumor necrosis factor-alpha


Input: Different effects of reoxygenation on the electrical activity of ventricular muscle.


Input: Similar observations were obtained when these mutated versions of site A were evaluated by transient cotransfection assays in CV1 cells.


Input: YLL031c is an essential gene.


Input: We have measured percentage O3 uptake in 30 adult Sprague-Dawley rats exposed, nose only, for 1 hr to 0. 3, 0. 6, or 1. 0 ppm O3.


Input: Threefold risks were observed for men with the highest level of intensity and for those with the highest probability of EMF exposure, although women with heavy EMF exposure did not experience increased risk.


Input: Further, cells cotransfected with a UF promoter-luciferase (-1935UF-Luc) reporter gene and the BTEB expression vector had 2-fold higher Luc activity than those cotransfected with reporter gene and pcDNA-3.

UF promoter

luciferase

Luc

BTEB

Luc


Input: Early complement components, C1q and C4, and IgA secretory piece were absent.

IgA


Input: Although IRS-1,-2, and-4 are similar in overall structure, IRS-3 is approximately 50% shorter and differs with respect to sites of tyrosine phosphorylation.

IRS-1,-2, and-4


Input: These results demonstrate a specific association of SIV and HIV-2 nef, but not HIV-1 nef, with TCRzeta.

HIV-2 nef

HIV-1 nef

TCRzeta


Input: METHODS: We retrospectively analyzed the data of 20 patients who underwent both gated fluorine 18 deoxyglucose (FDG)-PET and equilibrium radionuclide angiography (ERNA).


Input: The distinct spatial pattern of expression, and unusual amino acid sequence in its DNA binding domain, may indicate a particular role for DTEF-1 in cell-specific gene regulation.


Input: Rac2, a member of the Rho family of GTPases, is highly expressed in myeloid cells and is a regulator of the NADPH-oxidase complex.

Rho family

GTPases

NADPH-oxidase complex


Input: The yeast mitochondrial Hsp70, Ssc1p, functions as a molecular chaperone with its partner proteins, Mdj1p (DnaJ homologue) and Yge1p (GrpE homologue).

yeast mitochondrial Hsp70

DnaJ homologue

GrpE homologue


Input: The best sequences for pelvic study are, in our experience, IR or short TR spin-echo for T1-weighted images, and spin-echo with 1200 TR for T2 images.


Input: We now report that both HSCR mutations impair the fixation of Shc to RET and consequently prevent its phosphorylation.

HSCR

Shc

RET


Input: We now describe a HepG2 cell casein kinase II beta subunit cDNA of 2. 57 kb containing 96 bases of 5' untranslated sequence, 645 bases of open reading frame, and 1832 bases of 3' untranslated sequence with two polyadenylation consensus signal sequences and two poly (A) stretches.

HepG2 cell casein kinase II beta subunit cDNA


Input: Platelet factor 4 levels in patients with coronary artery disease.

Platelet factor 4


Input: Serum pituitary and steroid hormone levels in the adult male: one value is as good as the mean of three.


Input: Blood ammonia concentration was significantly higher in males at 70, 80 and 90% of VO2 peak.


Input: Here, we describe the crystal structure at 2. 5 A resolution of a fragment of the integrase of Rous sarcoma virus (residues 49-286) containing both the conserved catalytic domain and a modulatory DNA-binding domain (C domain).

integrase of Rous sarcoma virus (residues 49-286)


Input: The effect on kidney length was considerably prolonged compared with the vascular effect.


Input: The prevalence of microalbuminuria, defined as an UAER in the range of 15-150 micrograms min-1 in an overnight urine sample, was 3% (95% C. I. interval: 1. 9-4. 0).


Input: However, a lesser extent effect was noticed in nonpregnant than seen in pregnant rats.


Input: Despite their high degree of sequence similarity, all five RFC genes are essential for cell proliferation in S. cerevisiae.

RFC genes


Input: Rev.


Input: The strongly DNA binding p50 subunit showed only very weak, if any, induction of gene expression.

p50 subunit


Input: Stability of 125 I-labeled insulin used in radioimmunoassay of insulin.

insulin

insulin


Input: Influence of long-term zimelidine treatment on LSD-induced behavioural effects.


Input: Using mammalian expression vectors (pRSV-neo and pSV2-neo), antisense constructs for perforin and granzyme B were independently electroporated into YT-INDY, a human non-MHC-restricted, IL-2-independent, cytotoxic lymphocyte.

perforin

granzyme B

MHC


Input: When targeted to the GAL1 promoter by fusing with the Gal4p DNA-binding domain, Sko1p acts as an Ssn6/Tup1p-dependent repressor regulated by osmotic stress.

GAL1 promoter

Gal4p DNA-binding domain


Input: Like Rev-Erb, BD73 binds as a monomer to a DNA sequence which consists of a specific A/T-rich sequence upstream of the consensus hexameric half-site specified by the P box of the DNA-binding domain.

Rev

Erb


Input: BACKGROUND: Allergic rhinoconjunctivitis is a common disorder, affecting > 20% of people of all socioeconomic strata.


Input: INTERVENTIONS: Postoperative follow-up consisted of serial determination of different biochemical markers (CK, CK-MB, cTnI), ECGs, and echocardiography.

CK

CK-MB

cTnI


Input: The striking similarity in preference for mismatched and weakly paired nucleotides for binding and for excision suggests a functional relationship between binding and cleavage reactions.


Input: New results of importance for optimization of the postoperative course] Complications after major surgery may be related to factors in the surgical stress response with endocrine-metabolic and inflammatory changes.


Input: Immunoblotting showed that both the (1-404)-peptide and (1-506)-peptide are recognized by 95J10, a monoclonal antibody that was previously raised against perlecan-(24-404)-peptide expressed in Escherichia coli.


Input: Tumor necrosis factor levels were measured by enzyme-linked immunoabsorbent assay in plasma samples obtained from the hyperthermic isolated limb perfusion circuit and systemic circulation.

Tumor necrosis factor


Input: Serum alpha-amylase, trypsin, trypsin inhibitor, lipase and total protease activity in the pancreatic tissue was studied as indicator of the treatment efficacy with 5-fluorouracil electro-cumulation.

Serum alpha-amylase

trypsin

trypsin inhibitor

lipase


Input: The possible equivalency of a short form and the long form of the Multiple Affect Adjective Check List-Revised (MAACL-R; Zuckerman & Lubin, 1985) was studied by correlating both forms of the MAACL-R with the State Trait Personality Inventory (Spielberger, 1995); the Affect Balance Scale (Bradburn, 1969); and the Sensation Seeking Scale (Zuckerman, 1978).


Input: The activity of platelet factor 4 in plasma of healthy and high risk newborns.

platelet factor 4


Input: Studies of HS2-gamma gene reporter constructs carrying CACCC box deletions revealed that the CACCC box sequence of the gamma gene promoter mediates the activation of the gamma gene by FKLF.

HS2-gamma gene reporter constructs

FKLF


Input: In addition, mrp17-1, in combination with some mutations affecting another mitochondrial ribosomal protein, caused a synthetic defective phenotype.


Input: Erdheim-Chester disease: a distinct lipoidosis or part of the spectrum of histiocytosis? Erdheim-Chester disease has always been considered a distinct lipoidosis based on clinical and radiographic criteria.


Input: The ossification was located on the left side of C3-4.


Input: Characterization of human activating transcription factor 4, a transcriptional activator that interacts with multiple domains of cAMP-responsive element-binding protein (CREB)-binding protein.

human activating transcription factor 4

cAMP-responsive element-binding protein

CREB


Input: If the size of the cystic liver-lesions excludes a curative operative treatment or if the patient refuses surgery, the indication for chemotherapy with mebendazole is given.


Input: The Ixodes fauna in the Michourin region, where the pastures in 1971 were grazed only by sheep, shows the following trends: H. punctata and R. turanicus ticks, which are preferably parasitising in sheep, increase their relative share.


Input: The contribution of residues outside the Ras binding domain of Raf (RafRBD) to Ras-Raf interaction and Ras-dependent Raf activation has remained unresolved.

Ras binding domain

Raf

RafRBD

Ras

Raf

Ras

Raf


Input: We suggest that electrical stimulation of the NTS in rats undergoing such surgical preparation to observe the pressor response and/or increase in pVP, represents a rapid approach for screening the neurosecretory function of the central neural integration to release vasopressin.

vasopressin


Input: CONCLUSION/INTERPRETATION: We found an increased risk of hip fracture in women younger than 75 years with Type I diabetes or with Type II diabetes of long duration.


Input: Mean 24 h urinary excretion values confirmed this observation.


Input: Here we investigate the mechanism of TPA induction of FGF-BP gene expression in the human ME-180 SCC cell line.

FGF-BP


Input: They represent a physiologically more meaningful pattern than the arithmetic mean with standard deviation.


Input: The influence of gas composition in the air cell on pipping and liver metabolism in embryonic chicks.


Input: However, FosB-L and FosB-S do not differ in all trans-regulatory properties: Trans-activation of a 5x TRE-CAT reporter construct in HeLa and NIH-3T3 cells was found with both FosB forms.

FosB-L

FosB-S

TRE-CAT

FosB


Input: Numerous genes of this family have been identified in animals, with the largest number found in vertebrates.


Input: Mineralized bone nodule formation in vitro by cell populations from young adult rabbit alveolar bone.


Input: Soluble extracts from FGF-treated as compared with quiescent fibroblasts exhibited up to 3-fold higher kinase activity towards S6 in exogenously added rat liver 40S ribosomes and a synthetic peptide, RRLSSLRA.

FGF

rat liver 40S ribosomes


Input: In conclusion, when pulmonary abnormalities are found in HTLV-1 carriers, we should be careful in determining whether such pulmonary involvements are etiologically related to HTLV-1 infection.


Input: We found that 48% of the patients had their thoracolumbar blood supply based on two anterior radiculospinal arteries the lowest of which was located at, or lower than, T12, and the second and higher one between T6 and T10.


Input: Cross-species characterization of the promoter region of the cystic fibrosis transmembrane conductance regulator gene reveals multiple levels of regulation.

promoter region of the cystic fibrosis transmembrane conductance regulator gene


Input: The leader peptide was hypothesized to inhibit ribosome release at the tnaC stop codon, thereby blocking Rho' s access to the transcript.

tnaC stop codon

Rho


Input: We have isolated a unique murine FLT3 cDNA that codes for a variant isoform of FLT3, devoid of the fifth Ig-like domain, by comparison with the prototypic form.

murine FLT3 cDNA

Ig-like domain


Input: Thus, 22% of MDS responded to oral PLAC.


Input: Plasma beta-thromboglobulin (beta-TG), a platelet-specific protein, is a marker of intravascular platelet degranulation.

Plasma beta-thromboglobulin

beta-TG


Input: The Synechococcus gene rps1 encoding S1 is located 1. 1 kb downstream from psbB, which encodes the photosystem II P680 chlorophyll a apoprotein.

Synechococcus gene rps1

psbB

photosystem II P680 chlorophyll a apoprotein


Input: Additions of NH4 + up to 200 micrograms 1 (-1) were not stimulatory, whereas at 1. 0 mg 1 (-1) levels, Ke was 50% greater than for NO3-enriched medium.


Input: Pretreatment with lipid X was not necessary to improve survival: 16 of 17 (94%) infected and visibly ill animals that received lipid X and ticarcillin 6 h after thigh inoculation survived versus 30 of 44 (68%) control animals treated with ticarcillin alone (P less than 0. 0001).


Input: Between 1988 and 1994, data from 3 large sites revealed a 3-5 fold increase in the prevalence of antidepressant (ATD) treatment for U. S. youths aged 2-19 years.


Input: RESULTS: Analysis by Pearson' s correlation showed that the subjects who had higher scores of SSMS during the drum rotation generated the following: a) a higher rating of over-all sickness (r = 0. 76); b) a higher ratio of spectral power of EGG at 4-9 cycles per minute (cpm) between drum rotation and baseline periods (r = 0. 63); c) a higher net percent increase of spectral power in the EEG frequency band 0. 5-4 Hz between drum rotation and baseline periods on C3 (r = 0. 29) and C4 (r = 0. 31); d) a higher ratio of spectral power of EEG frequency band 0. 5-4 Hz between drum rotation and baseline periods on C3 (r = 0. 31); and e) a higher level of net increase in skin conductance from baseline to drum rotation (r = 0. 30).


Input: After inhibition of monoamine oxidase with pargyline (10 mg/kg. i. v.), the effects of tyramine (1000 micrograms) injected into the hepatic artery were potentiated.

monoamine oxidase


Input: However, the addition of intravenous injection of FPFD 101 resulted in a marked improvement in their symptoms.


Input: We report that Gcn5, a histone H3 acetylase, plays a central role in initiation of meiosis via effects on IME2 expression.

histone H3 acetylase


Input: In the presence of high concentrations (propofol 100 microg mL-1, thiopental 50 microg mL-1) marked relaxation was observed (propofol-32% up to-49%, P < 0, 05; thiopental-23% up to-67%, P < 0. 05).


Input: In further support of the biological significance of these DNA-protein interactions, the IL2RA oligonucleotide from-291 to-245 proved to be sufficient in either orientation to confer PMA inducibility to the mitogen-insensitive thymidine kinase gene promoter in Jurkat cells.

thymidine kinase gene promoter


Input: The amino acid residues and subdomains important for DNA binding, hormone binding, dimerization, and transactivation are mostly conserved among all VDR species.

VDR


Input: Here, we describe the nucleotide (nt) sequence and genomic organization of ipiB and ipiO.

ipiB

ipiO


Input: Specifically, we demonstrate that this 25-base pair region mediates the up-regulatory effect of TGF-beta on COL1A2 promoter activity and allows antagonistic activity of TNF-alpha on the TGF-beta effect.

TGF-beta

COL1A2 promoter

TNF-alpha

TGF-beta


Input: The phosphatidylglycerol/phosphatidylinositol transfer protein (PG/PI-TP) is a new and original phospholipid transfer protein (PLTP) isolated from the Deuteromycete, Aspergillus oryzae.

phosphatidylglycerol/phosphatidylinositol transfer protein

PG/PI-TP

phospholipid transfer protein

PLTP


Input: A 5789-nucleotide-long EcoRI fragment from the genome of Thermotoga maritima, identified by cross-hybridization to L11, L1, L10, and L12 ribosomal protein gene sequences from Escherichia coli, was cloned and sequenced.

5789-nucleotide-long EcoRI fragment

L12 ribosomal protein gene sequences from Escherichia coli


Input: Endotoxemia and bacteremia in patients with sepsis syndrome in the intensive care unit.


Input: Several 35-mm slides of dystrophin-, laminin-, and concanavalin A (ConA)-stained muscle sections were used to calculate myofiber cross-sectional areas and to compare different techniques and settings of an image capture system.

dystrophin

laminin

concanavalin A

ConA


Input: Indeed, after a single oral dose, the role of the mu-receptor agonist component of the antinociceptive effect of tramadol appears to be minor, with most of the analgesic effect being attributable to nonopioid properties of the parent compound.

mu-receptor


Input: The mRNA for this protein is expressed in the T-ALL cell line Jurkat and has been designated HUG1, for HOX11 Upstream Gene.

HOX11 Upstream Gene


Input: In solution, [(125) I]-labeled ankyrin was found by ND-PAGE3 to enhance the affinity of spectrin self-association by 10-fold.

ankyrin

spectrin


Input: The MEF-2 proteins are a family of transcriptional activators that have been detected in a wide variety of cell types.

MEF-2 proteins


Input: Jet lag and melatonin.


Input: Manual sample clean-up procedures as well as the addition of an internal standard are not needed.


Input: Treatment of diabetes and retinal complications


Input: In contrast, an N-terminal RNAP mutant that has a decreased capacity to bind single-stranded RNA forms halted complexes with much lower levels of stability than the WT enzyme, and these complexes are not stabilized by the presence of the NT strand.

N-terminal RNAP mutant


Input: The densities ranged between 2 and 3976 neurites/mm2 skin surface, but the overlap between subjects and without PHN was small.


Input: The present study demonstrates that the proto-oncogene c-jun represses transcription of the human CG alpha and CG beta promoters. c-Jun repressed the CG alpha promoter through a canonical cAMP response element (CRE) that is known to bind c-Jun and other members of the B-Zip transcription factor family.

proto-oncogene c-jun

human CG alpha

CG beta promoters

c-Jun

CG alpha promoter

c-Jun

B-Zip transcription factor family


Input: The mouse lactoferrin gene promoter was active in human endometrium carcinoma RL 95-2 cells and in rat glioma C6 cells.

lactoferrin


Input: This is the first report that the PH domain of an IRS protein can function in a dominant negative manner to inhibit insulin signaling.

PH domain

IRS protein

insulin


Input: Is exposure to a patient with Crohn' s disease an environmental factor for developing the disease.


Input: These findings suggest that low-power laser irradiation can be used for promotion of vascularization and take of tissue transplants.


Input: In experiment 1, subjects were required to discriminate male from female faces and no hemispheric asymmetries were found.


Input: For the albino, both the ST1 and ST2 spatial responses peak at around 0. 3 cycles deg-1, and both curves are displaced considerably to the low spatial frequency side of the normal ST2 spatial response.


Input: The scores for these three factors, which corresponded to recognizable dimensions of depressive illness, were then correlated with rCBF.


Input: The etiology was established in 73 (76. 8%) out of 95 cases.


Input: Depending on the patient' s body position telemetrically measured CSF-pressures varied between-20 cmH2O in erect and 15 cmH2O in supine position.


Input: Patients received either sodium cephalothin or placebo intravenously before the procedure and for up to 8 additional doses.


Input: These findings suggest that NMDA receptor blockade may ameliorate the dyskinetic complications of long-term levodopa therapy, without diminishing the beneficial effects on parkinsonian signs.

NMDA receptor


Input: Before flecainide, all patients had easily inducible VT that was morphologically identical to their spontaneously occurring arrhythmia.


Input: In cells infected with a recombinant vaccinia virus expressing HCV structural proteins (core, E1, and E2), DDX3 and core colocalized in distinct spots in the perinuclear region of the cytoplasm.

core

core


Input: However, PC12 cell clones which expressed p33rsu-1 at an increased level in a regulatable fashion in response to dexamethasone were isolated.


Input: Differential decay of a polycistronic Escherichia coli transcript is initiated by RNaseE-dependent endonucleolytic processing.

RNaseE


Input: An incorrect response on the previous trial enhanced the accuracy in the current trial only in the left visual field (LVF).


Input: The SEC27 gene was cloned, and the sequence predicts a 99. 4-kDa protein with 45% sequence identity to mammalian beta'-COP.

SEC27 gene

beta'-COP


Input: Column chromatographic determination of polymyxin B sulfate.


Input: Subgroup analysis failed to show any benefit for etoposide in patients with monocytic or myelomonocytic disease, or in any other diagnostic subgroup.


Input: Monosulfates of 16-oxygenated ketonic C19 steroids in adult human urine.


Input: A case of 2 cancers of the colon


Input: Pretoria Pasteurisation is feasible and reliable under a range of conditions.


Input: Computer analysis revealed that the human protein P1 sequence corresponding to amino acid residues within the N-terminal RNA binding domain displays high homology (greater than 54% identity; 61 to 94% similarity) with two animal virus proteins which possess RNA binding activity (vaccinia virus E3L; rotavirus VP2) and two proteins of unknown function (murine TIK; rotavirus NS34), but which are likely RNA binding proteins.

human protein P1 sequence

vaccinia virus E3L

rotavirus VP2

murine TIK

rotavirus NS34


Input: C/EBP delta (NFIL-6 beta) was not detected in complexes utilizing extracts from the IL-1 nonproducing T cell line.

C/EBP delta

NFIL-6 beta


Input: Noise in STM due to atoms moving in the tunneling space.


Input: However, mutations of the C-rich element that disrupted a GC box located on the inverse strand eliminated PMA responsiveness and, in gel mobility shift assays, eliminated binding of Sp1.


Input: This is a consensus casein kinase II (CKII) site and, using purified wild-type and mutant proteins, we show that it is the main CKII site in the body of the N-terminal complex-forming region.

casein kinase II

CKII

CKII site


Input: Down-regulation of Id1 mRNA correlated with mitogenesis and occurred when quiescent cells were treated with growth factors that activate G protein-coupled receptors and receptor protein tyrosine kinases but not with a non-mitogenic cAMP analog.

Id1 mRNA

G protein-coupled receptors

receptor protein tyrosine kinases


Input: To study adaptive processes following spinal cord injury, unstructured audiotaped interviews were conducted on an almost daily basis with a 30-year-old divorced male during the first 3 months of his initial comprehensive inpatient rehabilitation.


Input: Cloning and characterization of the 5' flanking region of human ATP-citrate lyase gene.

human ATP-citrate lyase gene