Input: Phenotypic analysis demonstrates that trio and Abl cooperate in regulating axon outgrowth in the embryonic central nervous system (CNS).

trio

Abl


Input: In the cervical enlargement they were located in the middle part of lamina VII and in lamina VIII, accounting for about 25% of the total labeled neurons.


Input: We measured electromyograms (EMG) of the alae nasi to determine the relationship between their activity and timing to contraction of the rib cage muscles and diaphragm during obstructive apnea in nine patients.


Input: A case control study (1: 2) of 182 pairs of Hepatitis A was carried out in Weng-ling Zhe-jiang during April 1988.


Input: In the absence of shock, sepsis, or other identifiable causes of lactic acidosis, the severe anemia (hemoglobin 1. 2 g/dl) appeared to be the primary etiologic factor.

hemoglobin


Input: However the precise function of DNA-PK in DNA double-strand break repair is not known.

DNA-PK


Input: The COR biosynthetic gene cluster in P. syringae pv. glycinea PG4180 is encoded by a 32-kb region which contains both the structural and regulatory genes needed for COR synthesis.

COR

COR


Input: Substitution of cholinergic drugs in the treatment of Alzheimer type dementia (AD/SDAT) has hitherto not been very successful.


Input: FEurea was also measured during stable graft function, 7-14 days prior to allograft dysfunction.


Input: The findings are discussed with reference to possible mechanisms by which parasite development might be controlled.


Input: Interestingly, basal MAPK, but not Raf-1, activity was constitutively enhanced in Jak1-deficient HeLa cells.

MAPK


Input: On the other hand hypokalemia, induced by diuretics, may also be accompanied by a significant depletion of total body K, bringing about more general consequences.


Input: We present here the complete primary structure of human gp330, the human variant of the principal kidney autoantigen causing Heymann membranous glomerulonephritis in rats.

human gp330


Input: A series of deletion mutants was expressed transiently in two human hepatocytes, HepG2 and PLC.


Input: Biol.


Input: Copyright 2000 Academic Press.


Input: No patient demonstrated a decrease in bone marrow fibrosis as determined by serial procollagen (PC III) serum level analysis.

procollagen

PC III


Input: In four calves given Haemonchus contortus larvae, the serum pepsinogen concentration rose quickly to reach a mean of 3. 5 iu tyrosine on day 14 after infection.

serum pepsinogen


Input: The P-ITIM-compelled multi-phosphoprotein complex binds to and activates SHP-2, which in turn dephosphorylates SHIP and Shc and probably other substrates.

P-ITIM-compelled multi-phosphoprotein complex

SHIP

Shc


Input: Paradoxically, loop 3i from the M1Ach-muscarinic receptor also maximally inhibited GnRH agonist-stimulated cAMP accumulation and PRL release by 40% (both effects mediated through activation of the Gs protein).

M1Ach-muscarinic receptor

GnRH

PRL

Gs protein


Input: Electrophoretic mobility-shift assays with nuclear extracts from COS-1 cells transfected with expression vectors for SMADs 1-5 indicate that SMAD3 forms a complex with a migration similar to that of the endogenous TGF-beta-specific complex observed in fibroblast extracts.

SMADs 1-5

endogenous TGF-beta-specific complex


Input: Oligomers corresponding to the region of the mlc-1/3 enhancer, which encompasses this conserved sequence, bound MEF-2 and competed for its binding to the mck enhancer.

mlc-1/3 enhancer

mck


Input: cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2.

GC box-binding protein


Input: N0 disease is more favorable than N1 or N2 disease.


Input: Elimination of brush border as well as of glomerular marker proteins was significantly lower after intravenous injection of low-osmolar CM iopamidol 370 (832 mOsm/kg) than after meglumine diatrizoate 76 (2100 mOsm/kg).


Input: Overall graft and patient survival after HAT were 33. 3% and 75%, respectively.


Input: Of 81 girls cured from the bacteriuria 24 recurred, 5 with a symptomatic pyelonephritis and 3 with cystitis.


Input: Partial hepatectomy in metastatic Wilms' tumor.


Input: MRS allowed the differentiation of the following metabolites in 5 patients: N-acetyl-aspartate (NAA), creatine and phosphocreatine, phosphorylcholine and glycerophosphorylcholine, beta-and gamma-glutamate (GLU).


Input: Plasma prolactin in patients with colorectal cancer.

prolactin


Input: Studies of fetal maturity


Input: A comparison of the rate of recovery and time for detection of mycobacteria from clinical specimens of the newly developed Mycobacteria Growth Indicator Tube (MGIT), the biphasic Septi-Chek, and the egg-based Ogawa medium was made.


Input: E2A-HLF-mediated cell transformation requires both the trans-activation domains of E2A and the leucine zipper dimerization domain of HLF.

HLF

HLF


Input: In transient transfections using luciferase reporter genes driven by 1 kb of the 5' flanking DNA of the three CALM genes, the promoter activity correlated with the endogenous CALM transcriptional activity, but only when the 5' untranslated regions were included in the constructs.

luciferase reporter genes

CALM genes

endogenous CALM


Input: In this report, several health behaviors were investigated in relation to maintaining mobility during 4 years of follow-up among 6, 981 men and women aged 65 years and older with intact mobility at baseline between 1981 and 1983 who lived in one of three communities: East Boston, Massachusetts; Iowa and Washington counties, Iowa; and New Haven, Connecticut.


Input: Binding of ZAP-70 to phospho-TAMs is notable for the high level of cooperativity between the two SH2 domains, which individually demonstrate low affinity interaction with the ligand.

SH2 domains


Input: A clinical study.


Input: Two-dimensional echocardiographic parasternal long-and short-axis views were obtained during graded bleeding by rapid withdrawal of blood from an arterial cannula, with increments of 5% each up to 30% of calculated blood volume.


Input: Comparative analyses indicate that the 5'-peripheral domain exhibits a 75-bp length polymorphism near sequences associated with the termination of the H-strand replication.


Input: Thirty-five pts were transplanted for constitutional disease: Fanconi anemia (FA) (26 pts), Dyskeratosis congenita (2 pts), Blackfan-Diamond erythroblastopenia (2 pts), Glanzmann thrombasthenia (1 pt), osteopetrosis (1 pt) and Gaucher' s disease (1 pt).


Input: One patient exhibited a non-sense mutation (codon 388), which changed a glutamine codon (CAG) to a stop codon (TAG).


Input: Using the same approach we have shown that hFIRE binds the stimulatory proteins Sp1 and Sp3 in addition to CBF.

hFIRE

CBF


Input: Cellular fractionation and Percoll gradient centrifugation combined with immunoblotting show that p67 cofractionates with nuclei and is enriched in resistant structure that is insoluble in 2 M NaCl, 25 mM lithium 3, 5'-diiodosalicylate, and 1% Triton but is soluble in 8 M urea.


Input: Gene expression is in part controlled by chromatin remodeling factors and the acetylation state of nucleosomal histones.

nucleosomal histones


Input: Corticosteroid treatment before, during, or after fludarabine treatment in patients with alkylator-resistant, low-grade lymphoid malignancies who have not received PCP prophylaxis is associated with an increased risk of opportunistic pulmonary infections.


Input: Here we demonstrate that several genes associated with NHEJ perform essential functions in the repair of endonuclease-induced DSBs in vivo.


Input: The primary structure of cholesterol esterase displayed no significant homology with other lipases, although the putative lipid interfacial recognition site of G-X-S-X-G is present in the cholesterol esterase sequence.

cholesterol esterase

lipases

cholesterol esterase sequence


Input: Subtype-and response element-dependent differences in transactivation by peroxisome proliferator-activated receptors alpha and gamma.

peroxisome proliferator-activated receptors alpha and gamma


Input: Monoclonal antibodies to the hapten phenyloxazolone were raised 7 days after immunization in mice of six strains (BALB/c, C57BL-Igha, DBA2, RF, A/J, and CE).


Input: PMA produced similar results, but the induction of the WT AP1 c-jun promoter-CAT plasmid was smaller.

WT AP1 c-jun


Input: Although the QT duration was higher (p = 0. 0001) at night, the beat-to-beat variability of this interval was lower: in the time domain (decreased standard deviation, p = 0. 0005), in the frequency domain (decreased low-frequency power of the spectra, p = 0. 004), and the chaotic domain (tighter clustering of the points in the Poincare plots).


Input: J.


Input: Student health


Input: In both study stages. post-exposure treatment consisted of five injections of vaccine [(D) ays 0, 3, 7, 14, 28], together with a dose of rabies immunoglobulin (RIG) of equine or human origin on D0.

rabies immunoglobulin

RIG


Input: Essential fatty acid deficiency in childhood


Input: We have earlier proposed that CG rich sequences resembling CpG islands, which are associated with many imprinted genes and often subject to parental-specific methylation, could act as a common imprinting element.


Input: Electrophoretic mobility-shift assays showed a rapid induction of nuclear proteins that bound to the consensus kappa B motif.

consensus kappa B motif


Input: The thalamic SD was regularly triggered by short (0. 02-0. 05 s) high-frequency (200-500 Hz) ES of the parietal cortical surface.


Input: As in IncP alpha plasmids, these operons are transcribed from a bidirectional promoter region consisting of trfAp for the trfA operon and trbAp and trbBp for the trb operon.

trfAp

trfA operon

trbAp

trbBp

trb operon


Input: Comparison of the encoded ERCC3Dm protein with the homologous proteins of mouse and man shows a strong amino acid conservation (71% identity), especially in the postulated DNA binding region and seven' helicase' domains.

ERCC3Dm protein

' helicase' domains


Input: Genetic analysis places CWH43 upstream of the BCK2 branch of the PKC1 signalling pathway, since cwh43 mutations were synthetic lethal with pkc1 deletion, whereas the cwh43 defects could be rescued by overexpression of BCK2 and not by high-copy-number expression of genes encoding downstream proteins of the PKC1 pathway However, unlike BCK2, whose disruption in a cln3 mutant resulted in growth arrest in G (1), no growth defect was observed in a double cwh43 cln3 mutants.

cln3 mutant

cwh43 cln3 mutants


Input: Expression of the E2 protein resulted in rapid repression of HPV E6 and E7 expression, followed approximately 12 h later by profound inhibition of cellular DNA synthesis.

E2 protein

HPV E6


Input: Peak reactive hyperemia (mL. min-1. 100 mL-1) was determined in the calf and forearm immediately before and after 12 weeks of training.


Input: The hematopoietic form of PTPN6 transcript is initiated at a downstream promoter separated by 7 kb from the first.

PTPN6 transcript


Input: Reversal of biliary sphincter spasm with low dose glucagon during operative cholangiography.

glucagon


Input: In ten other endotoxin-albumin-treated pigs PGE1 infusion (0. 25 micrograms X kg-1 X min-1) was begun after established pulmonary and cardiovascular dysfunction, for closer mimicking of clinical use.

albumin


Input: In particular, MF males receiving either a 5. 0-mg/kg CDP dose or a 3. 0-mg/kg RO dose explored the object more often than MM males. (ABSTRACT TRUNCATED AT 250 WORDS)


Input: A single HD session using cellulose triacetate or polysulfone membrane significantly increased water content both at forearm and lower leg (p < 0. 05).


Input: In the yeast two-hybrid assays, PNRC interacted with the orphan receptors SF1 and ERRalpha1 in a ligand-independent manner.

PNRC


Input: Further, we will review our evaluation of the survival rate and prognostic factors for 9, 262 patients from 1981 to 1996.


Input: Kaposi' s eruptive disease.


Input: The results were subjected to analysis of 23 autopsies carried out in children dying of intoxication with Amanita phalloides.


Input: Microscopic examination of these colonies showed a high percentage of histiocytes identical to those seen in the patient' s bone marrow.


Input: Diffusion epidemic models with incubation and crisscross dynamics.


Input: Additional genetic analyses described herein suggest that Skb1 is a component of the morphology control branch of the Ras signaling cascade in S. pombe and that it positively modulates Shk1 function.

Ras


Input: Transient transfection assays indicated that the (-4551) UCP1-CAT construct, containing the 5'-regulatory region of the rat ucp-1 gene, was activated by PPARalpha co-transfection in a dose-dependent manner and this activation was potentiated by Wy 14, 643 and retinoid X receptor alpha.

CAT

rat ucp-1 gene

PPARalpha

retinoid X receptor alpha


Input: CRKL, an SH2-SH3-SH3 adapter protein, is one of the major tyrosine phosphoproteins detected in primary leukemic neutrophils from patients with CML.

CRKL

tyrosine phosphoproteins


Input: Idealized versus realized overall treatment times.


Input: Serum C3 was measured in 1, 282 school children with abnormal urinary findings between 1980 and 1997.

Serum C3


Input: Tc-99m HMPAO brain SPECT compared to CT and EEG after seizures in childhood.


Input: The adenovirus E1B 19, 000-molecular-weight (19K) protein is a potent inhibitor of apoptosis and cooperates with E1A to transform primary rodent cells.

adenovirus E1B 19, 000-molecular-weight (19K) protein


Input: Subclones of R15 which reverted to kappa light chain production contained genomic deletions of R15ns and/or the surrounding intron.

kappa light chain


Input: Previous data suggested a subtle increase in serum P at the time of hCG injection without LH surge reduces the PR of women having oocyte retrievals for IVF; this study compared PRs of recipients in a shared oocyte program according to the donors' pre-hCG P level.

hCG

LH

pre-hCG


Input: Scleraxis overexpression enhanced expression of the aggrecan gene, which is not normally expressed at high levels in these osteoblastic cells.

Scleraxis

aggrecan gene


Input: Region-specific enhancers near two mammalian homeo box genes define adjacent rostrocaudal domains in the central nervous system.

mammalian homeo box genes


Input: Cells were cotransfected with this plasmid, and the appropriate responder plasmids and clonies were selected on the basis of their resistance to Geneticin (via the neomycin aminoglycoside phosphotransferase gene).

neomycin aminoglycoside phosphotransferase gene


Input: To clone cDNAs for the beta subunit of rabbit eIF-2B, amino acid sequence data was first obtained and used to design redundant oligonucleotide primers for use in PCR.

rabbit eIF-2B


Input: Deletion analysis of the 3. 5kb DNA fragment revealed that the region between-125 to + 1, containing a single Sp1 binding site, is essential for transcription of the embigin gene.

Sp1 binding site

embigin gene


Input: A 29. 425 kb segment on the left arm of yeast chromosome XV contains more than twice as many unknown as known open reading frames.


Input: By applying a sufficiently strong crusher gradient in the EPI pulse sequence, the temporal variation induced by SSFP disturbance can be suppressed due to diffusion.


Input: The cdc42W97R temperature-sensitive allele in S. cerevisiae displayed the same cell-division-cycle arrest phenotype (large, round unbudded cells) as the cdc42-1ts mutant.

cdc42W97R temperature-sensitive allele

cdc42-1ts mutant


Input: Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4 (4p16. 3).


Input: To address this question with respect to skeletal muscle, we have examined the effects of the Providence mutation in cultured muscle cells, after adoptive gene transfer to adult mice, and in two infants homozygous for spectrin Providence.

spectrin Providence


Input: Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexes.

PTEN

cyclin E


Input: Increasing insulin sensitivity in type I diabetic patients should alert clinicians to the possibility of glucocorticoid deficiency.

insulin


Input: Experiment B: Clinical, biochemical, and histological variables were measured over a 12-day period after the zymosan had been given.


Input: Lesions of this kind resemble those in vitamin A-deficient chickens and are the first to be induced by excess vitamin E.


Input: Immunoblotting using a phosphospecific anti-Src (416Y) antibody showed a ceramide-induced increase in pp60 (src) tyrosine phosphorylation.

phosphospecific anti-Src (416Y) antibody

src


Input: Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines.

Spinophilin

protein phosphatase 1 binding protein


Input: The Htf9-a gene encodes the RanBP1 protein, a major partner of the Ran GTPase.

Htf9-a gene

RanBP1 protein

Ran GTPase


Input: Membrane extraction has been interfaced with gas chromatography and mass spectroscopy for the analysis of volatile organics in water.


Input: We have produced the Ure2 protein to high yield in Escherichia coli from a synthetic gene.

Ure2 protein


Input: Triethylene glycol.


Input: The SM-specific selection of exon 2 results from the inhibition of exon 3.


Input: Ultimobranchial body and parathyroid glands of the freshwater snake Natrix piscator in response to vitamin D3 administration.


Input: In contrast to the p16-mediated G1 block, G1 arrest mediated by the cdk inhibitors p21Cip1 or p27Kip1 cannot be bypassed either by inactivation of pRb or overexpression of E2F family members.

cdk

pRb

E2F family members


Input: More than 80% appropriate lever responding was established after 27, 38 and 44 daily training sessions with DN-2327, diazepam and PTZ, respectively, as the training drug.


Input: In the present study, we have investigated the effects of SDZ ENA 713 on spatial learning deficits in aged rats.


Input: A retrospective analysis of data accumulated over a 21-month period, from December 1989 to September 1991, regarding investigational use of a 308 nanometer Xenon Chloride Excimer Laser Coronary Angioplasty (ELCA) system (Advanced Interventional Systems, Inc., Irvine, CA) was performed.


Input: Upon increasing the Marangoni number beyond this threshold, the initially stationary flow becomes quickly time dependent.


Input: Investigation on the asymmetrical induced yields in 90Sr-90Y-beta-irradiated D-and L-alanines.


Input: One of the major transcripts encodes MEQ, a 339-amino-acid bZIP protein which is homologous to the Jun/Fos family of transcription factors.

MEQ

bZIP protein

Jun

Fos


Input: Given a rapid induction of Egr-1 on stimulation with growth factors or injury, these findings may represent at least one of the molecular mechanisms underlying phenotypic modulation of smooth muscles after vascular injury.


Input: An identical polypeptide was detected by Western blot analysis of K1F virions.


Input: The predictive value of the remotely sensed map based on NDVI data appears to be better than that from forecast indices based only on climatic data.


Input: The concentration of vitamin B1, B2 and B6 are found to be 9. 96, 9. 92 and 3. 01 mg, respectively in 240 mg of capsule powder of a standard company (name has not been disclosed due to secrecy purpose).


Input: We have shown that the human cell MRC closely resembles the murine cell MRC, in both its protein composition and its fractionation and chromatographic profile.


Input: Red blood cell binding of 99mTc-EC and 131I-OIH was 6. 1% and 20%, respectively.


Input: Identification of a 68-kilodalton nuclear ATP-binding phosphoprotein encoded by bovine papillomavirus type 1.

68-kilodalton nuclear ATP-binding phosphoprotein


Input: To identify the GRK6 homologue on chromsome 13, several sets of closely-spaced primers were designed based on the GRK6 cDNA sequence and then used to amplify human genomic DNA by PCR.

GRK6 homologue

GRK6 cDNA sequence


Input: During the burst period (approximately 5-10 min), local blood H2O2 concentrations and xanthine oxidase activities were highly correlated (r = 0. 999).

xanthine oxidase


Input: This mutant also functions in vivo as a trans-acting dominant negative regulator: the transcriptional inducibility of the HIV long terminal repeat (which contains two potential NF-kappa B binding sites) by phorbol ester (PMA) is inhibited when it is co-transfected into CD4 + T cells with the delta SP mutant.

HIV long terminal repeat

NF-kappa B binding sites

CD4 +


Input: We demonstrate that the WRM-1 protein binds to LIT-1 in vivo and that WRM-1 can activate the LIT-1 protein kinase when coexpressed in vertebrate tissue culture cells.

WRM-1 protein

LIT-1 protein kinase


Input: To assess the safety of the angiotensin converting enzyme inhibitor enalapril a multicenter, open, randomized, prazosin-controlled trial was designed comparing the incidence and severity of symptomatic hypotension on the first day of treatment.

angiotensin converting enzyme


Input: Mutating bases-142 to-151 abolishes formation of complex VII and partially inhibits complex IV, suggesting that the proteins forming these complexes bind neighboring segments of DNA.


Input: In this study, we report the cloning and sequencing of several overlapping cDNAs encoding approximately 4. 1 kb of the human homologue of Wnt-5A.

human homologue of Wnt-5A


Input: We provided evidence that CaM kinase II played a role in regulating neurite outgrowth and growth cone motility in these cells, and that the autophosphorylation is essential for the kinase to sufficiently exert its cellular function in vivo [Y.

CaM kinase II


Input: We propose that GCD7 and GCD2 play important roles in the regulatory interaction between eIF-2 and eIF-2B and that the suppressor mutations we isolated in these genes decrease the susceptibility of eIF-2B to the inhibitory effects of phosphorylated eIF-2 without impairing the essential catalytic function of eIF-2B in translation initiation.


Input: Furthermore, we demonstrate that in myeloid and B cell extracts, PU. 1 forms a novel, specific, more slowly migrating complex (PU-SF) when binding the GM-CSF receptor alpha promoter PU. 1 site.

PU. 1

PU-SF

GM-CSF receptor alpha

PU. 1


Input: The antiserum used for immunoblotting specifically supershifts uteroglobin promoter-protein complexes in gel shift experiments.

uteroglobin promoter-protein complexes


Input: Plasma LH and progesterone levels after single or multiple injections of synthetic LH-RH in anoestrous ewes and comparison with levels during the oestrous cycle.

Plasma LH

LH

RH


Input: Soluble recombinant RI and soluble recombinant C alpha can associate in vitro and be activated by cyclic AMP.

RI

C alpha


Input: We have isolated and structurally characterized genomic DNA and cDNA sequences encoding ribulose-1, 5-bisphosphate carboxylase/oxygenase (Rbu-P2 carboxylase) activase from barley (Hordeum vulgare L.).

ribulose-1, 5-bisphosphate carboxylase/oxygenase (Rbu-P2 carboxylase) activase


Input: Cytokine inducibility of VCAM1 in endothelial cells utilizes the interaction of heterodimeric p50/p65 proteins with IRF-1.


Input: The cases with terminal forces of left ventricular activation in the same direction as the delta wave, superiorly and to the left at-60 degrees or inferiorly and to the right at + 120 degrees, forming a single deflection of over 0, 12 seconds' duration, are the result of delayed activation of the anterior or posterior fascicle of the left bundle after a long delay.


Input: From a chromosomal cosmid library of Streptomyces argillaceus, a Mtm producer, a clone (cosAR7) was isolated by homology to the actI/III region of S. coelicolor and the strDEM genes of S. griseus.

Mtm

actI/III region

strDEM genes


Input: A 31-year-old man with primary myelofibrosis initially received low dose Ara C.


Input: The factors defective in groups A (CIITA), C (RFX5) and D (RFXAP) have been identified.

CIITA

RFXAP


Input: Manifestation of superfluidity in an evolving bose-einstein condensed Gas We study the generation of excitations due to an " impurity " (static perturbation) placed into an oscillating Bose-Einstein condensed gas in the time-dependent trapping field.


Input: By sequencing of exonuclease III deletion clones an open reading frame of 405 nucleotides was found coding for a protein of 135 amino acids with a molecular mass of 15 kDa.

exonuclease III


Input: The c-raf-1 proto-oncogene is the cellular homologue of v-raf, the oncogene of the acutely transforming retrovirus 3611-MSV.

c-raf-1 proto-oncogene

cellular homologue of v-raf


Input: We report the genomic organization of the mouse orphan receptor related to tyrosine kinases (Ryk), a structurally unclassified member of the growth factor receptor family.

orphan receptor related to tyrosine kinases

Ryk

growth factor receptor


Input: Electrophoretic mobility-shift assays between viral RNA and BMV CP peptides with either proline or alanine substitutions revealed that the interaction is nonspecific.

BMV CP peptides


Input: Furthermore, we detect hCoch-5B2 on three overlapping YACs, two of which also contain one of the markers linked to DFNA9. mCoch-5B2 was genetically mapped in the mouse to chromosome 12, in a region of homologous synteny with human 14q11. 2-q13, which contains the asp1 (audiogenic seizure prone) locus in the mouse.

audiogenic seizure prone


Input: Reasons are given for suggesting that tiapamil warrants further clinical evaluation, after which it may join the more established calcium antagonists as a valuable therapeutic agent.


Input: Histopathologic studies displaying spongiform changes in the gray matter, neuronal loss, and atrogliosis confirmed the clinical diagnosis of Creutzfeldt-Jakob disease.


Input: Current body size (wt/ht2) was significantly associated with life-time weight dissatisfaction in both sexes (P less than 0. 0005).


Input: Our results are consistent with TCOF1 mutations leading to the Treacher Collins syndrome phenotype.

TCOF1 mutations


Input: Mannich bases of vanillin oxime.


Input: Its activity was twice that of a construct where the CAT gene was driven by the H-2Kb 5' enhancer region (H2TF1/KBF1 site) and comparable to that of pRSVCAT construct carrying the strong Rous sarcoma virus LTR enhancer.

CAT gene

H-2Kb 5' enhancer region

construct carrying the strong Rous sarcoma virus LTR enhancer


Input: CONCLUSIONS: These findings imply that the spinal cord is not a simple command-carrying medium from the brain to the limbs, and implies that some computational activities take place at the spinal cord level.


Input: The dipper (RONF of BP (or HR) > or = 10% 2.


Input: I.


Input: Acute spontaneous subdural haematoma.


Input: Nonsuicidal mortality in late-life depression.


Input: DSS4-1 is a dominant suppressor of sec4-8 that encodes a nucleotide exchange protein that aids Sec4p function.


Input: A study of characteristics in adult asthmatics who are sensitized by cats and dogs allergens


Input: The failure suggests that these assembly competent but complementation-negative alpha mutants lack an as yet unidentified function (s).


Input: Ciprofloxacin levels in serum and blister fluid at the end of the dosing interval (8 h) were superior or almost superior to MICs for sensitive organisms including Pseudomonas aeruginosa.


Input: However, both peptides 1-49 and 63-87 bound to PDE alpha/beta in a solid-phase binding assay.

PDE alpha/beta


Input: SETTING: A private office-based fertility program.


Input: Our results showed that direct enantiomeric separation of mephenytoin was obtained by using a chiral capillary column, the retention times for S-and R-mephenytoin were 25. 5 and 26. 2 min respectively, with a detection limit less than 50 ng/ml of mephenytoin.


Input: The consensus mammalian ER stress response element (ERSE) conserved among grp promoters consists of a tripartite structure CCAAT (N9) CCACG, with N being a strikingly GC-rich region of 9 bp.

grp promoters


Input: Further, we find that the BMI1 protein can also interact with itself.

BMI1 protein


Input: These data suggest that certain of the nuclear protein import functions of NTF2 and Ran/TC4 are closely linked and that NTF2 may serve to modulate a transport step involving Ran/TC4.

Ran

Ran


Input: Our analysis indicates that a gene correction mechanism has been operating on the Hbbs chromosome to keep beta s and beta t evolving in concert, whereas on the Hbbd chromosome, beta dmin has diverged considerably from beta dmaj.

Hbbs

beta s

beta t

Hbbd

beta dmin

beta dmaj


Input: The prosomal RNA-binding protein p27K is a member of the alpha-type human prosomal gene family.

prosomal RNA-binding protein p27K

alpha-type human prosomal gene family


Input: Because controlled-release niacin seems to be more potent than crystalline niacin, product substitution without dose adjustment should be avoided.


Input: Expression of the gene encoding transcription factor cyclic adenosine 3', 5'-monophosphate (cAMP) response element-binding protein (CREB): regulation by follicle-stimulating hormone-induced cAMP signaling in primary rat Sertoli cells.

transcription factor cyclic adenosine 3', 5'-monophosphate (cAMP) response element-binding protein

CREB

follicle-stimulating hormone


Input: Comparison of the therapeutic effectiveness of membrane and centrifugation plasmapheresis


Input: Number of warm-units with higher rates of firing and greater thermal coefficients, comparable to those of warm-units in the adult, gradually increased with growth.


Input: To investigate the effect of hyperthyroidism on the pattern and time course of O2 uptake (VO2) following the transition from rest to exercise, six patients and six healthy subjects performed cycle exercise at an average work rate (WR) of 18 and 20 W respectively.


Input: 88, 3739-3743)).


Input: CHIEF OUTCOME MEASURES: Endoluminal release of prostacyclin (6-Keto-PGF1 alpha) and thromboxane B2 (TxB2), patency, EC coverage and cell identity.


Input: Elevated systolic blood pressure and high postglucose serum insulin levels showed an independent, significant association with left ventricular mass in female diabetic subjects.

serum insulin


Input: Seasonal variation of the cadmium content of Murex trunculus in a non-cadmium polluted environment.


Input: The total area under the blood glucose curve over the initial value was not altered 2 h after treatment with SH B 209 AB or Neogynon.


Input: Serum IgM levels showed a highly significant increase in all types of brain tumour when compared to controls.

Serum IgM


Input: Here we describe the characterization of cDNAs encoding two unusual E2Fs, E2F-4 and E2F-5, each identified by the ability of their gene product to interact with p130 in a yeast two-hybrid system.


Input: Ultra-energy (UHE) imaging is usually performed in simultaneous F-18 FDG/Tc-99m MIBI studies.


Input: However, electron microscopy revealed that while sec4 mutant cells accumulate secretory vesicles, ypt31/32 mutant cells accumulate aberrant Golgi structures.

sec4 mutant

ypt31/32 mutant


Input: Furthermore, Grap is associated with a Ras guanine nucleotide exchange factor mSos1, primarily through its N-terminal SH3 domain.

Grap

Ras guanine nucleotide exchange factor mSos1

N-terminal SH3 domain


Input: Correlation of nitrogen, carbohydrate and lipid metabolic indices in rats cooled under conditions of an altered gaseous environment


Input: Transfer of F-like plasmids is regulated by the FinOP system, which controls the expression of traJ, a positive regulator of the transfer operon.

FinOP

traJ


Input: This regimen may be considered front-line therapy when autologous stem cell transplantation is not feasible and when a rapid response is particularly important.


Input: To investigate this issue, we used a recognition task in which two strings of letters are presented sequentially.


Input: Comparison to the murine homologues of these molecules reveals a high degree of conservation between the products of one of these genes, Fc gamma RIIb, and the murine beta gene in primary sequence, splicing pattern, and tissue distribution.

Fc gamma RIIb

murine beta gene


Input: A rabbit antiserum raised against a unique (V3 domain) bacterially expressed PKC theta fragment immunoprecipitated specifically an 82-kDa protein from Jurkat cell lysates.

PKC theta fragment


Input: These changes persisted during the first week.


Input: Hematological parameters (leukocyte, neutrophil and platelet counts) and liver function tests were determined by standard procedures.


Input: (1993) 8, 94-99).


Input: The effect of betamethasone on duodenal calcium absorption and 1, 25-dihydroxy vitamin D3 production in the chick.


Input: Phosphate compounds in isolated, perfused hearts during pH variation due to changes in extracellular PCO2 and bicarbonate


Input: We report on a case discovered in a 13 year-old girl presenting with anaemia.


Input: Although analysis of the similarity between the 44-kDa protein and the E. coli RecA protein did not show any significant homology between them, it revealed their identity by five amino-acid residues involved in the formation of the epitope that recognized the paratope of the RecA protein antibody for subsequent epitope-paratope binding of these proteins.

E. coli RecA protein

RecA protein antibody


Input: It would seem that caution should be exercised in using HPL values as an index of placental function in anaemic women.

HPL


Input: No IORT related mortality has been observed.


Input: Characterization of a tonB-phoA gene fusion suggests that the amino-terminal 41 amino acids of TonB are sufficient to promote export of the fusion protein and presumably TonB as well.

tonB

phoA

TonB

TonB


Input: Characterization of a unique protein component of yeast RNase MRP: an RNA-binding protein with a zinc-cluster domain.

yeast RNase MRP


Input: This raises the possibility that recombination occurred between corresponding LTR and vif loci of the quasi-species present in the isolates described here.

vif loci


Input: The antihypertensive action corresponds to those of established diuretics.


Input: These results are discussed in relation to predicted isoform L diversity across human tissues and cells.


Input: In the healing tendons, the rate of collagen synthesis decreased and the rate of noncollagen protein synthesis remained unchanged.

collagen


Input: The aromatic hydrocarbon receptor (AHR) is a ligand-activated transcription factor that regulates the expression of several drug-metabolizing enzymes and has been implicated in immunosuppression, teratogenesis, cell-specific hyperplasia, and certain types of malignancies and toxicities.

aromatic hydrocarbon receptor

AHR


Input: Fluctuations of the measured ECF energy-related substances corresponded to various clinical events presumably involving hypoxia/ischemia.


Input: After 3 months of intervention, sustained physical training was associated with the decrease of FVII and PAI-1 levels.

FVII


Input: The metalloproteinase mediating Met cleavage was specifically inhibited by the tissue inhibitor of metalloproteinases (TIMP)-3, but not by TIMP-1 or TIMP-2.

metalloproteinase

Met

tissue inhibitor of metalloproteinases (TIMP)-3


Input: This constant expression profile, coupled with the observation that over-expression of mSin3A does not augment the anti-Myc activity of Mxi1-SR in the rat embryo fibroblast (REF) transformation assay, suggests that mSin3A is not a limiting factor in the regulation of Myc superfamily function.

anti-Myc

Myc superfamily


Input: METHODS AND RESULTS: The effect of prolonged nitrate therapy between 2 days and 6 weeks during healing after infarction on serial parameters of ventricular remodeling (scar expansion, scar thinning, ventricular dilation, and hypertrophy) and function (asynergy or akinesis plus dyskinesis and ejection fraction) by serial two-dimensional echocardiography, hemodynamics, postmortem topography (computerized planimetry, geometric maps, and radiographs), and collagen content (hydroxyproline) was studied in 64 instrumented dogs randomized 2 days after left anterior descending coronary artery ligation to various nitrate regimens (n = 32) over the first 2 weeks (subgroup 1: 2% transdermal nitroglycerin at 8 AM and 4 PM, n = 6; subgroup 2: 2% transdermal nitroglycerin plus 2. 6 mg of sustained-release oral nitroglycerin at 8 AM, 3 PM, and 10 PM, n = 5; subgroup 3: oral isosorbide dinitrate, 30 mg at 8 AM and 4 PM, n = 11) or 6 weeks (subgroup 4: isosorbide dinitrate, n = 10) and in matching controls (n = 32).

collagen


Input: A nationwide survey uncovered a tenfold variation between counties in the prescribing of IFNB.

IFNB


Input: We have demonstrated that a putative HOX cofactor, PBX1A, participates in cooperative DNA binding with HOXA-1 and the Deformed group protein HOXD-4.

HOX cofactor

Deformed


Input: RESULTS--261 patients were enrolled into this study; of these, 138 (53%) patients attended for repeat colposcopy and cytology at one year.


Input: We have found that pro-IGF-2 can initially form two disulfide isomers that undergo rearrangement to a single conformation in vivo.


Input: Thus, primate vs. rodent promoter selectivity mediated by the TBP-TAFI complex is likely to be the result of cumulative subtle differences between individual subunits that lead to species-specific properties of RNA polymerase I transcription.

TBP

TAFI

RNA polymerase I


Input: Anti-Jo-1 antibody was not present.

Anti-Jo-1 antibody


Input: The structure and expression of the murine gene encoding granulocyte-macrophage colony stimulating factor: evidence for utilisation of alternative promoters.

murine gene encoding granulocyte-macrophage colony stimulating factor


Input: Cotransfection of pINV-2473, a construct containing 2473 base pairs of hINV upstream sequence linked to luciferase, with POU homeodomain transcription factors Oct1, Oct2, Brn4, SCIP, Skn1a or Skn1i, results in a strong suppression of basal promoter activity.

hINV upstream sequence

luciferase

POU homeodomain transcription factors Oct1

SCIP


Input: Central treatment unit saves nurses, adds income, improves care.


Input: The Grb2 SH3 (C) binding region of Gab1 has significant homology to a region of the adapter protein SLP-76.

Grb2 SH3 (C) binding region

adapter protein SLP-76


Input: The QCS appears comparable with the MMSE and is quicker to administer.


Input: A positive FTA-ABS-19S-IgM test indicates the necessity of treatment.


Input: A DNA binding protein was identified which binds to two novel target-like sequences: (i) at the 5' flanking site of the breakpoint junction of chromosome 8 in a patient with T-acute lymphoblastic leukemia (ALL) carrying the t (8; 14) (q24; q11) rearrangement and (ii) on chromosome 1 in three of five T-ALL patients with the t (1; 14) (p32; q11) rearrangement.


Input: The effect of iron on the toxigenicity of Vibrio cholerae.


Input: The rest of the 3' untranslated sequences were common to both cDNA clones.


Input: The anesthesiologist and the cardiac surgeon.


Input: The three proteins copurified through several biochemical fractionation steps and could be coimmunoprecipitated by using antibodies against GCD1 or GCD2.


Input: From 1998 to 1999, a large number of community-acquired respiratory tract isolates of Streptococcus pneumoniae (n = 566), Haemophilus influenzae (n = 513) and Moraxella catarrhalis (n = 228) were collected from 15 centres in Australia, Hong Kong, Japan, China, the Philippines, Singapore, South Africa and Taiwan through the SENTRY Antimicrobial Surveillance Program.


Input: Rats on the multiple oral dosage regimen were given unlabelled HMCF in their drinking water for 13 days before the administration of a bolus dose of [14C] HMCF on day 14.


Input: In order to search for mutations in the multicopy RBM genes that might be associated with male infertility, we have used sequence data from the reported cDNA clone to determine the intron exon boundaries of the YRRM 1 gene.

multicopy RBM genes

YRRM 1 gene


Input: Uterine contractions began with a mean latency of 62 min in the PGF2 alpha infused women, in controls uterine activity remained unchanged.


Input: The implication of Rac and Cdc42 was analyzed in transient transfection experiments using either constitutively active (V12) or dominant-interfering (N17) mutants.

Rac


Input: The evolutionary significance of the similarities of intron secondary structures and open reading frames of the ND3, 4 and ATPase 6 genes is discussed, including the possible separate evolution of structural and coding sequences.

ND3, 4 and ATPase 6 genes


Input: Although there is evidence that cone ratios do determine colour appearance under many conditions, the site or sites of their computation is unknown.


Input: Procedures with perfected method


Input: In an effort to identify factors involved in the expression of this important erythroid-specific regulatory protein, we have isolated the mouse EKLF gene and systematically analyzed the promoter region.

mouse EKLF gene


Input: Accordingly, superpeptide antigenic material was readily detected by immunoblotting cell extracts and enriched in vacuolar preparations of PrA deficient mutant cells.

PrA


Input: RESULTS: All primary tumors were positive for CAM5. 2.

CAM5. 2


Input: However massive necrosis of the renal tubules had been found with more than 15mg of DSM administration.


Input: A case of functioning parathyroid carcinoma with hypereninemic hypertension.


Input: Together with a number of phase II trials, phase I trials utilizing escalating doses of carboplatin and paclitaxel with growth factor or growth factor and blood stem-cell support have shown that substantial increases in dose intensity can be achieved.


Input: The study was performed in a class 100 laminar flow clean bench in order to minimize particulate contamination from extraneous sources.


Input: Moreover, since the integrated transforming DNA was not altered or lost expression of the RbcS2:: aadA:: RbcS2 gene (s) appears to be repressed.

aadA

RbcS2 gene (s)


Input: In contrast, the holo-dTFIIA (L/S) binds TBP with high affinity.

holo-dTFIIA

TBP


Input: In one trial, 116 subjects with transfusion-related chronic hepatitis C were treated with lymphoblastoid interferon (5 MU/m2 three times a week for 2 mo, then 3 MU/m2 three times a week for 4 or 10 mo).

lymphoblastoid interferon


Input: These results demonstrate the preferential endometrial cell-type expression of BTEB and suggest its regulatory role in pregnancy-associated endometrial epithelial gene expression.

BTEB


Input: The sequence of LZ321 matched that of RREB1, a transcription factor that bound to a Ras responsive element (RRE) very different from the sequence with which we isolated LZ321.

Ras responsive element

RRE


Input: Phosphorylation at Ser (670) impairs the ability of GRK2 to phosphorylate both soluble and membrane-incorporated receptor substrates and dramatically attenuates Gbetagamma-mediated activation of this enzyme.

Gbetagamma


Input: However, the sequence of mRAR-beta 3 region A differs from that of mRAR-beta 1 by an additional 27 C-terminal amino acids encoded in an 81 nucleotide-long putative exon which is spliced in between the exons encoding the A and B regions of mRAR-beta 1.

mRAR-beta 3 region A

mRAR-beta 1

A and B regions of mRAR-beta 1


Input: Rad18 is required for DNA repair and checkpoint responses in fission yeast.


Input: The longest S1-S2 interval at which S2 failed to capture (effective refractory period) was longer by 5. 5 +/-8. 2 msec at twice threshold (0. 05 less than p less than 0. 10) and 5. 5 +/-3. 5 msec at 5 times threshold stimulation (p less than 0. 01) when the basic drive and extrastimuli were delivered to separate sites.


Input: Using lasers, PRK involves reshaping the cornea so that its refractive power is increased.


Input: Using in vivo screening, we first identified a gene that appeared to interfere with the His-Asp phosphorelay between the HPt domain and the receiver domain of OmpR, provided that the gene product was expressed through a multicopy plasmid.

OmpR


Input: In addition, six other landmarks favored the xeroradiograph but not to the degree of statistical significance.


Input: Coronary vasoconstriction caused by endothelin-1 is enhanced by ischemia-reperfusion and by norepinephrine present in concentrations typically observed after neonatal cardiopulmonary bypass.


Input: Inhibition of Raf-1 signaling by a monoclonal antibody, which interferes with Raf-1 activation and with Mek substrate binding.

Mek


Input: Laparoscopic examination 1 year after surgery revealed an enlarged, thin-walled, and fluid-filled uterine segment cranial to the midcornus occlusion sites in all animals.


Input: NBSII is essential for ribosome-stimulated activity.


Input: Gel shift and southwestern experiments revealed nuclear proteins of 43 kDa and 30 kDa in GC and fish cells, respectively, that bind specifically to the tGH CRE, suggesting the involvement of CRE-binding-protein/activating-transcription-factor-l-related peptides in cAMP response.

tGH

CRE-binding-protein

activating-transcription-factor-l


Input: Moreover, such mutations lead to a dramatic transition in chromatin structure: the DNase I hypersensitive region is replaced by two stable, sequence-positioned nucleosomes.

DNase I hypersensitive region


Input: Two measures of sensory inhibition were employed, S2/S1 x 100 amplitude ratio and S1-S2 amplitude difference.


Input: The transcriptional start site, identified by primer extension and S1 nuclease assay, is 34 nt upstream of the translation initiation codon.

S1 nuclease


Input: The clinical effects of valproate and ethosuximide can be related to this differential modulation of thalamocortical excitability.


Input: Central projections of gastric afferent vagal inputs.


Input: Our results suggest a biological role for Elf-1 in the regulation of IgH gene expression, attribute a functional role for receptor-induced AP-1 proteins in B lymphocytes and provide evidence for a direct link between IgM receptor-mediated signalling and 3' enhancer activation.

IgH gene

AP-1 proteins

IgM receptor


Input: Like Mdm2, MdmX is able to bind p53 and inhibit p53 transactivation; however, the ability of MdmX to degrade p53 has yet to be examined.

MdmX

MdmX


Input: The structure of the mAR ORF was confirmed by sequence analysis of mAR cDNA fragments, which were obtained by PCR amplification of mouse testis cDNA, using mAR specific primers.

mAR

mAR

mAR


Input: Transforming growth factor-beta (TGF-beta) inhibits cell cycle progression, in part through up-regulation of gene expression of the p21 (WAF1/Cip1) (p21) cell cycle inhibitor.

Transforming growth factor-beta

TGF-beta


Input: Decreased plasma level of antithrombin III was assumed to be one of the major factors underlying hypercoagulable state in nephrotic syndrome.

antithrombin III


Input: In both RAW cells and the microglia cell line EOC20, two IFN-gamma-activated transcription factors, STAT-1alpha and IRF-1, bind the GAS and IRF elements, respectively.

IFN-gamma

GAS

IRF elements


Input: All patients received marrow from HLA-identical sibling donors, underwent similar myeloablative regimens, and had similar pretreatment characteristics.

HLA


Input: In Types I and II, capillary walls became thinner and more capillary lumens were visiable.


Input: Immunoblot analyses revealed that the loss of activator function coincides with selective removal of the C-terminal domain (CTD)-hyperphosphorylated RNAP IIO along with NC2.

C-terminal domain (CTD)-hyperphosphorylated RNAP IIO


Input: In bell pepper, a gene encoding a major plastid-lipid associated protein is expressed as both partially and totally spliced transcripts (respectively PAP2 and PAP1).


Input: Aggregation in washed platelets from rats with diabetes was enhanced.


Input: Instead, the large difference in ssDNA-binding affinities reflects the loss of hexamerization ability by uvsY, suggesting that a form of intrahexamer synergism or cooperativity between binding sites within the uvsY hexamer leads to its high observed affinity for ssDNA.

uvsY

uvsY hexamer


Input: The authors investigate in a group of 211 children aged 2-6 years, incl. in particular a group of 33 2-year-old ones, in 1990 and checked in 1991 at two sites in Bratislava--a town with a varying concentration of NOX, SO2, dustiness and dust fallout--their influence on the incidence, type and course of relapsing respiratory disease.


Input: Such results suggest that there are no differences in the BMR of age-and weight-matched Asian Indian males, other tropical populations and Americans.


Input: CONCLUSION: DaunoXome has an improved pharmacokinetic profile compared with free daunorubicin, and is well tolerated.


Input: Furthermore, the zincon-loaded resin was applied to the selective concentration of trace amounts of chalcophile elements in natural water samples prior to neutron activation analysis.


Input: Analyses focused on two platyrrhine (New World monkey) species: the common marmoset (Callithrix jacchus) and the brown capuchin monkey (Cebus apella), each of which has paired, non-allelic gamma loci (5'-gamma 1-gamma 2-3').


Input: Over half of the children initially unresponsive to H. influenzae type b meningitis subsequently developed specific antibodies.


Input: The electron spin resonance study also demonstrated that the formation of superoxide-DMPO spin adduct was strongly inhibited by a selective cyclooxygenase-2 inhibitor, etodolac, in a concentration-dependent manner.


Input: Sox8 maps to the t complex on mouse chromosome 17 and to human chromosome 16p13. 3, a region associated with the microphthalmia-cataract syndrome CATM and the alpha-thalassemia/mental retardation syndrome ATR-16.

t complex


Input: If vascular induction between a vascular carrier and the selected jejunal segment is done as a kind of flap prefabrication, the jejunal interposition flap can be used without the need for complex microsurgery.


Input: There was no difference in the day-42 cure rates between the QC7 (n = 65) and A7 (n = 64) regimens with an efficacy of 100% in both, confirmed by parasite genotyping.


Input: Acetyl-CoA carboxylase from yeast is an essential enzyme and is regulated by factors that control phospholipid metabolism.

Acetyl-CoA carboxylase


Input: The NH (2)-terminus of all three proteins contains a POZ domain, a conserved 120 amino acid motif involved in transcriptional repression and protein dimerization.


Input: Recognition of DNA by single-chain derivatives of the phage 434 repressor: high affinity binding depends on both the contacted and non-contacted base pairs.


Input: In the absence of Mg2 +, the extent of destabilization of tRNAPhe is greater but appears to be confined to internal regions of the acceptor and T psi C helices, as evidenced by the selectively enhanced exchange rates for imino protons associated with these base pairs.

tRNAPhe


Input: This gene is named PKNOX1 by the Human Nomenclature Committee.


Input: The carboxyl-terminal 75 amino acids of the two proteins contain the bHLH motif and differ from each other by only three conservative amino acid changes, while the amino-terminal portions are markedly divergent from each other.


Input: A Drosophila subobscura genomic fragment containing all the exons and the late and early promotors in the Sxl gene of D. melanogaster was isolated.

Sxl gene of D. melanogaster


Input: The data from animal experiments indicate that the incidence of solid tumors in marrow transplant patients may still rise in the coming decades.


Input: The results of the transient-transfection assay showed that the Sp1 binding element located in the core region (positions--64 to + 1) of the alpha2-integrin promoter plays an essential role in the alpha2-integrin promoter activity and its downregulation by Erb-B2.

Sp1 binding element

alpha2-integrin promoter

alpha2-integrin promoter

Erb


Input: These observations suggest that the AF-1 region of PPARalpha is partially silenced by corepressor proteins, which might interact in a phosphorylation-dependent manner.

PPARalpha


Input: Evaluation of the effects of chelation therapy with time following strontium exposure to mice.


Input: Insertion of alternatively spliced exon W into CREB mRNA during spermatogenesis results in a polycistronic RNA that encodes two novel internally translated CREB repressor isoforms called I-CREBs, consisting of the carboxy-terminal DNA-binding domain devoid of the transactivation domains.

CREB mRNA

CREB repressor isoforms

I-CREBs


Input: The human BRCA1 promoter also contains a conserved E2F site and is similarly regulated by E2F1 and Rb.

human BRCA1 promoter

E2F site

Rb


Input: In the studies described in this report, we have identified two potential Ets binding sites, EBS1 and EBS2, which are conserved in both the human and murine interleukin-2 enhancers.

Ets


Input: An enhancement of benign liver tumors (tumorigenic effect) was observed only in CF1 male mice (17/56 at the only tested dose: 400 ppm vs.


Input: Stamps in cardiology: de Musset sign.


Input: Here, we analyzed the interaction of CYT-18 with a small RNA (P4-P6 RNA) corresponding to the isolated P4-P6 domain of the N. crassa mitochondrial large subunit ribosomal RNA intron.

P4-P6 RNA

P4-P6 domain

N. crassa mitochondrial large subunit ribosomal RNA intron


Input: 268, 6858-6861).


Input: Polyglutamine-containing protein fragments have been shown to accumulate as aggregates in the nucleus and in the cytoplasm, and to induce cell death when expressed in cultured cells, leading to the proposal that polyglutamine aggregation is an important step in the pathogenesis.


Input: We have previously shown that the transcriptional activator CREM is highly expressed in postmeiotic cells.

CREM


Input: For more detailed mapping, we constructed mouse A9 cells containing STFs derived from human chromosome 2 tagged with pSTneo at different regions in 2q31-qter.


Input: We therefore propose that PRR2, and not PVR, is the true human homolog of MPH.

PVR

MPH


Input: We have analyzed herein the roles that four different PIAS proteins (ARIP3/PIASx alpha, Miz1/PIASx beta, GBP/PIAS1, and PIAS3) play in the regulation of steroid receptor-or STAT-mediated transcriptional activation.

PIAS proteins

PIASx alpha

PIASx beta

GBP

steroid receptor

STAT


Input: Yet testosterone was predominant in the plasma of the Type II male morph which neither courts females nor nests, but instead parasitizes Type I males with sneak or satellite spawning tactics.


Input: To better understand the relationship between expression of an oncogene and genetic instability, we have studied a cell line expressing an activated human Ha-ras under the control of bacterial lactose operon regulatory elements for changes in methotrexate resistance and dihydrofolate reductase (dhfr) gene amplification following mutant Ha-ras induction.

activated human Ha-ras

bacterial lactose operon regulatory elements

dihydrofolate reductase

dhfr

mutant Ha-ras


Input: Cbl is a signaling molecule with multiple functional domains: an SH2 domain which binds phosphotyrosine residues, a RING finger domain which acts as a ubiquitin ligase, a proline-rich region which serves as a docking site for SH3-containing proteins, phosphotyrosine residues which serve as docking sites for SH2-containing proteins such a CrkL and the p85 subunit of PI 3-kinase, and a nuclear localization signal.

Cbl

SH2 domain

ubiquitin ligase

SH3-containing proteins

SH2-containing proteins

CrkL

p85 subunit

PI 3-kinase


Input: No interaction with epidural anesthesia was observed.


Input: Region I includes the two cysteine-cysteine zinc fingers that comprise a DNA-binding domain which typifies all members of the superfamily.


Input: Leukocytoclasic vasculitis during treatment with low-dose captopril


Input: In contrast to Phase III, which has a single study design--the controlled, randomized, double-blind study--Phase IV requires different designs for each of the many different questions.


Input: The results suggest that both superficial and deep cortical venous drainage of the cat kidney should be considered when measuring renal renin release.

renal renin


Input: The aim of this work was to organize chemical data in a client-server environment using Database Management System and Web fashion for the client interface.


Input: This bound [3H] iloprost with high affinity and stimulated cAMP production when exposed to agonist.


Input: The deduced amino acid sequence exhibits 95. 3 and 76. 1% identity with the CAD sequences of hamster and Squalus acanthias.

CAD sequences of hamster and Squalus acanthias


Input: Juvenile idiopathic inflammatory myopathies: the value of magnetic resonance imaging in the detection of muscle involvement.


Input: The methods used were the AOAC method of dilution and heating; the addition of mercuric chloride, charcoal, and Carrez reagents at 2 different pH values; and direct analysis of sample supernatants with no treatment (control).


Input: In src-transformed cells GAP forms heteromeric complexes, notably with a highly tyrosine phosphorylated 62-kDa protein (p62).

src

GAP

62-kDa protein (p62)


Input: Genomic Southern analysis reveals 10 to 15 hybridising fragments, suggesting that maize contains a small gene family.


Input: The signal-to-noise ratio (SNR) was calculated in the T2-weighted sequence.


Input: The MIC90 of ABK against coagulase type IV strains was rather high, 12. 5 micrograms/ml.

coagulase type IV


Input: A review of 156 patients younger than 40 treated at our Department between 1960 and 1991 with transitional cell carcinoma of the bladder revealed that 89. 1% had superficial (Ta/T1) disease and the remaining 10. 9% presented with invasive disease.


Input: Expression of the Asp but not the Ala gB mutation resulted in an increase in the steady-state expression of gB at the plasma membrane (PM) in U373 cells.

gB

gB


Input: Large volumes of bone marrow may be required for certain types of autologous bone marrow transplants.


Input: These results suggest that dauricine and verapamil have a salutary effect in extracorporeal circulation.


Input: Central-venous-catheter-related infection is readily diagnosed by comparing simultaneous quantitative cultures of blood samples obtained via the catheter and a peripheral vein.


Input: For evaluation of the model, simulations of physiological excitation and of pathologies (Wolff-Parkinson-White syndrome, complete AV-block, inferior wall ischaemia) were examined.


Input: For rotating stimuli presented to the dominant eye, this class of neurons responded best to rotation of the visual world about an axis oriented near the horizontal plane and approximately 45 degrees azimuth.


Input: Protein kinase C transiently activated heteromeric N-methyl-D-aspartate receptor channels independent of the phosphorylatable C-terminal splice domain and of consensus phosphorylation sites.

Protein kinase C

heteromeric N-methyl-D-aspartate receptor channels


Input: The incidence of the variability of the free PSA/total PSA ratio on the early diagnosis of prostate cancer

PSA

PSA


Input: Moreover, we show that ectopic expression of the E2A protein E12 in this macrophage line results in the induction of many B lineage genes, including EBF, IL7Ralpha, lambda5, and Rag-1, and the ability to induce kappa light chain in response to mitogen.

E2A protein E12

EBF

kappa light chain


Input: A TAAATA sequence is present 26 nt upstream from the major CAP site, and within the 5'-flanking region there are several putative transcription factor binding sites.


Input: OBJECTIVES: The present study tested the hypothesis that stimulating the central noradrenergic system using the new noradrenaline re-uptake inhibitor reboxetine would result in a dose-dependent enhancement of memory for emotional material in man.


Input: Iris binding and bioavailability.


Input: The dopamine D1 dopamine receptor antagonist SCH 23390 dose dependently (7. 5-30 micrograms/kg s. c.) antagonized the stimulant locomotor effect on both drugs but did not prevent their antiimmobility effect on the behavioral despair test.

dopamine D1 dopamine receptor


Input: Neither symptoms, virions, nor viral RNA was detectable in plants inoculated with this mutant or a mutant with a frameshift mutation in the coat gene.

coat gene


Input: Chromaffin cells transfected with a plasmid with the entire coding sequence of c-Rabphilin3a inserted in the antisense orientation inhibited secretion of co-expressed GH by approximately 30%.

GH


Input: A sequence-ready 3-Mb PAC contig covering 16 breakpoints of the Wilms tumor/anirida region of human chromosome 11p13.

Wilms tumor/anirida region


Input: Compression of pulmonary artery and right ventricular outflow tract by aneurysm of ascending aorta.


Input: The sulfur species could be separated within less than 4 min by CZE with a pyromellitic acid electrolyte at pH 3. 5 to 5. 0.


Input: High expression of p51A (TAp63gamma) in the skeletal muscle tissue drove us to investigate a differentiation-inducible myoblastic cell line which showed increased p51A expression after differentiation induction.


Input: Nosographic problems


Input: Since UmuD protein is proteolytically processed to an active form (UmuD *) in a RecA *-dependent fashion, and MucA shares extensive amino acid homology with UmuD, we examined whether MucA is similarly processed in the cell, using antiserum against a LacZ'-' MucA fusion protein.

UmuD protein

UmuD *

RecA

MucA

UmuD

MucA

LacZ'

' MucA


Input: Changes in BHR were found to correlate significantly with changes in the levels of 24 h mean SO2, NO2 and smoke; 48 h mean NO2 and smoke; 24 h lag NO2; although the effect was only small, accounting for approximately 10% of the variability in within-subject BHR between visits.


Input: 50-nucleotide) intron to AA.


Input: Foamy viruses (FVs) express the Gag protein as a precursor with a molecular mass of 74 kDa (pr74) from which a 70-kDa protein (p70) is cleaved by the viral protease.

Gag protein


Input: Identification of domains mediating transcription activation, repression, and inhibition in the paired-related homeobox protein, Prx2 (S8).

paired-related homeobox protein


Input: Because of the structural similarities the new gene will be termed scERV2 from now on.


Input: Where the resonator has two holes, these terms should be somewhat modified: A is the combined area of the two holes, L is 16/3pi r (~ 1. 7r) for a simple hole in a thin-walled vessel and r is the radius of one hole (Seto, 1971).


Input: The most distal active site in TIGA is created by excision of a 66-bp intron.

TIGA


Input: GeneCalling analysis was successful in detecting members of complex metabolic pathways and uncovering novel genes that were either coincidentally regulated or directly involved in such pathways.


Input: Cerebellar functional compensation after its complete destruction by a neoplasm


Input: Analysis of the DNA sequence upstream of the narQ gene, which encodes the second nitrate-responsive sensor-transmitter protein in Escherichia coli, revealed an open reading frame (ORF) whose product shows a high degree of similarity to a number of iron-sulfur proteins as well as to the beta subunit of glutamate synthase (gltD) of E. coli.

narQ gene

iron-sulfur proteins

glutamate synthase

gltD


Input: Thus, the antibody class switch appears to be directed by induction of accessibility, as assayed by transcription of germ line CH genes.

CH


Input: With repetitive intermittent exercise, gradual increases in blood lactate concentration [(LA] b) occurred, whereas its rate of accumulation (delta [LA] b) decreased.


Input: Wingless/Wnt signaling directs cell-fate choices during embryonic development.

Wingless

Wnt


Input: In CYP7A1 transgenic mice, livers contained approximately 3-fold more sterol response element-binding protein-2 mRNA.

sterol response element-binding protein-2 mRNA


Input: Patients with the chronic photosensitivity dermatitis with actinic reticuloid syndrome have high total serum IgE concentrations.

IgE


Input: Furthermore, the cognate binding protein is present in both rat and human (HeLa) cell nuclear extracts.


Input: The effect of stimulation of the entopeduncular nucleus (EP) on the jaw-opening reflex (JOR) was studied in the cat anesthetized with sodium pentobarbital.


Input: We cloned the BamHI-F fragment from the left end of Ad4 in pUC13-1 between the SalI and BamHI sites in order to carry out the structural analysis of the E1A region of Ad4.

BamHI-F fragment

SalI

BamHI sites

E1A region of Ad4


Input: Results of this study indicate that when amniotic fluid samples are stored frozen and strict quality control is maintained in analytic procedures, only minimal changes occur in phospholipid concentrations over 12 months.


Input: The objective of this research was to determine if ergotamine, an ergopeptine alkaloid isolated from Neotyphodium-infected grasses and associated with toxicoses in livestock, altered plasma concentrations of reproductive hormones in follicular phase heifers and in cows given a progestin implant.


Input: The following parameters were measured: onset time (time interval from injection to maximal or total block), T125/75 (time for T1 to reach 25% or 75% of control), TOF70 (time for TOF ratio to reach 70% of control), heart rate and blood pressure.


Input: Ectopic Xbra can induce Xegr-1 transcription by an indirect mechanism that appears to operate via primary activation of fibroblast growth factor secretion.

Xbra

fibroblast growth factor


Input: A total of 10, 763 men and 3, 118 women has been studied, of whom 97% and 89%, respectively, have been traced and 36% and 16% have died.


Input: The association of I-92 with p92, p84, p75, p73, p69, and p57 was completely reversible after treatment with the detergent deoxycholate (DOC).


Input: Although the elevated signalling is eliminated by deletion of Ste20p (or components downstream of Ste20p), the growth and morphological abnormalities of cells lacking Akr1p are not rescued by deletion of any of the known pheromone response pathway components.


Input: 2) Depending on the structure, certain compounds are sequestered in the cornea (presumably the stroma) and form a release system into the anterior aqueous.


Input: To gain further insights into these events, the porcine G alpha i-3 gene minimal promoter was characterized and found 67 base pairs upstream from the major transcription start site.

porcine G alpha i-3 gene minimal promoter


Input: Two authors, two journal titles, two drug names, and two topics of a general medical nature were retrieved under identical circumstances and conditions on the hosts DATA-STAR, DIALOG, DIMDI, and STN.


Input: For example, the presence of two related genes, b and b', in the cyanobacterium suggests that its ATP synthase is a complex of nine polypeptides, and that it may have single copies of related b and b' proteins rather than two copies of identical b subunits as found in the E. coli enzyme. 4 + off

b

b'

ATP synthase

b

b' proteins

b subunits


Input: DDD (R) pacing with automatic mode switch in patients with paroxysmal atrial fibrillation following AV nodal ablation.


Input: These events were only weakly stimulated by the activated PDGF alpha-receptor.

activated PDGF alpha-receptor


Input: These results establish that the DNA fragment we have isolated contains the human gp130 promoter and that interleukin-6 type cytokines may influence the activity of this promoter via activated STATs.

human gp130 promoter

interleukin-6 type cytokines

STATs


Input: Only 53% of all injuries and 12. 5% of serious injuries involved children, and in contrast to the 1950s and early 1960s, young adults appear at greatest risk in the 1980s.


Input: Three simple methods of detecting malnutrition on medical wards.


Input: We also show that an internal fragment of U24 methylation guide snoRNA, encompassing the upstream antisense element and the D' and C' box motifs, can support the site-specific methylation of rRNA.

U24 methylation guide snoRNA


Input: The gap protein knirps mediates both quenching and direct repression in the Drosophila embryo.

gap

knirps


Input: One of them is its limited sensitivity to weak interactions, which are common in the mammalian cerebral cortex.


Input: An infant of 8 months with congenital glaucoma and hemophilia A lost one eye due to haemorrhages after trabeculotomy in an eye hospital.


Input: Encapsulation of sodium fluorescein for dye release studies.


Input: Ethanol preference in strains of rats selectively bred for behavioral characteristics.


Input: VAV and SOCS1 form a protein complex through interactions between the VAV NH (2)-terminal regulatory region and the SH2 domain of SOCS1 in a phosphotyrosine-independent manner.

VAV

VAV NH (2)-terminal regulatory region

SH2 domain


Input: Incubation of HeLa cell cytoplasmic extracts with a purified recombinant glutathione S-transferase-raf fusion protein in the presence of ATP released active NF-kappa B that could be detected by electrophoretic gel mobility shift assay.

glutathione S-transferase

raf

NF-kappa B


Input: Cefminox shows greater in vivo activity than that expected for the MICs, excellent efficacy and safety.


Input: Both the p38 kinase inhibitor SB205380 (SB) and cotransfection of a dominant-negative mutant of p38 kinase reduced IL-1beta stimulation of the hBNP promoter.

p38 kinase

p38 kinase

hBNP promoter


Input: Recent geological studies focusing on the Davie Fracture Zone of the Mozambique Channel offer a resolution to this situation, by suggesting the presence of a land-bridge from the mid-Eocene to the early Miocene, an interval that matches the ages of Madagascar' s mammalian groups.


Input: We have previously demonstrated that pyrene in diesel-exhaust particles (DEP) has an adjuvant activity on immunoglobulin E (IgE) antibody production in mice immunized with Japanese cedar pollen allergen (JCPA) or ovalbumin (OA) intraperitoneally.

immunoglobulin E

IgE

ovalbumin

OA


Input: On the basis of 8 cases, the authors report different clinical pictures all caused by cardiac toxicity of 5FU.


Input: The immunoprofile of 60 adult patients of pulmonary tuberculosis was studied and compared with 22 normal controls.


Input: Effects of long-term use of raloxifene, a selective estrogen receptor modulator, on thyroid function test profiles.

estrogen receptor


Input: Module 2 of RifA lacks a beta-ketoacyl: acyl carrier protein reductase (KR) domain and the one in module 3 has an apparently inactive NADPH binding motif, similar to one found in the Er PKS, while the other eight KR domains of the Rf PKS should be functional.

RifA

beta-ketoacyl: acyl carrier protein reductase

KR

NADPH binding motif

Er PKS

KR domains

Rf PKS


Input: Synergy between interferon-gamma and tumor necrosis factor-alpha in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor kappaB.

interferon-gamma

tumor necrosis factor-alpha

signal transducer and activator of transcription 1

nuclear factor kappaB


Input: The corresponding tetrapeptide sequences SSPD and SATD for human and mouse PKC-epsilon, respectively, are unusual for caspase-3.

human and mouse PKC-epsilon


Input: The effect of pneumoperitoneum on dissemination and scar implantation of intra-abdominal tumor cells.


Input: CONCLUSIONS: In the results of this study, SDB, even snoring, was independently associated with hypertension in both men and women.


Input: A poly (ortho ester) designed for combined ocular delivery of dexamethasone sodium phosphate and 5-fluorouracil: subconjunctival tolerance and in vitro release.


Input: Subclones stably expressing alpha1A-, alpha1B-, and alpha1D-ARs under control of an inducible promoter, or at high and low receptor density, were isolated and characterized.


Input: Transfection of both Calu-6 and JEG-3 cells with a PKA expression vector resulted in a 10-fold induction of human renin transcriptional activity in constructs containing the native or consensus CRE and 5-fold activation in a construct containing a nonfunctional CRE.

PKA

human renin


Input: In renal vein thrombosis, similar pattern to acute tubular necrosis was found but RI venography was helpful.


Input: Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors.

murine atonal-related bHLH protein


Input: Oligo-[alpha]-deoxynucleotides can be derived by stabilizing (intercalating) agents or reactive groups (cleaving reagents, cross-linkers...).


Input: Electronic structure of Si (111)-NiSi2 (111) A-type and B-type interfaces.


Input: In addition, two cis-acting elements direct the first zygotic expression of Kr in a striped subpattern within the central region of the blastoderm embryo.

Kr


Input: Embryonal mortality


Input: Regardless of muscle tensioning or marination treatments, aging of the carcass for 24 h (T1, T2, and T3) produced meats with lower shear values than those from hot-boned carcasses (T4 and T5).


Input: This effect was stronger after multiple predoses of sertraline, when imipramine Cmax and AUC (0-infinity) were increased by 39% and 68%, respectively.


Input: For capsules containing only the drug, the value of T50 increased as the particle size of the drug decreased.


Input: Its prognostic impact is superior to the T1/2 one (RR = 2. 9; p = 0. 0010).


Input: We also show that in fusions with the DNA binding domain of GAL4, full activity requires the entire BHV-alpha TIF, although both amino and carboxyl termini display some activity on their own.

BHV-alpha TIF


Input: As well, variation in capillary size and density was apparent between ventricles in the fetal and neonatal periods.


Input: Previous studies have demonstrated that the 21-or the 72-bp repeat transcriptional control elements enhance the efficiency of SV40 DNA replication in vivo, provided either of these repeats is located near the end of the core replication origin containing the 17-bp A + T-containing sequence.


Input: It is pathogenetically proved to use antithrombin III concentrate preparations with anti-and dysaggregatory properties, fibronectin preparations, trasylol or its analogs during complex preoperative preparation of patients.

antithrombin III

fibronectin


Input: ER and DR were significantly correlated with MIB-1 LI (P < 0. 01 and P < 0. 05, respectively), but RI and Td/Te were not.


Input: D., and Long, C.


Input: A lead phthalocyanin method for the demonstration of acid hydrolases in plant and animal tissues.

acid hydrolases


Input: On the sixth postirradiation day the absorption of phenobarbitone, sulphafurazole and mecamylamine had returned to the control level, but the absorption of quinidine and isoniazid was still retarded.


Input: Here, we describe the three-dimensional structure of the enzyme from Escherichia colidetermined and refined to 2. 0 A resolution.


Input: cDNA cloning, sequencing and chromosome mapping of a non-erythroid spectrin, human alpha-fodrin.

non-erythroid spectrin

human alpha-fodrin


Input: In serial recall from short-term memory, repeated items are recalled well when close together (repetition facilitation), but not when far apart (repetition inhibition; the Ranschburg effect).


Input: Posterior osteophytes around the posterior edges of vertebral body resulted in intervertebral insufficiency, and corresponded to hypertrophic spur in osteochondrosis.


Input: LV compliance was determined from the slope of the LV end-diastolic pressure (LVEDP) vs.


Input: Biol.


Input: There was no significant correlation between serum amiodarone or desethylamiodarone levels and dosage of amiodarone.


Input: Nuclear extracts from Sertoli cells were found to cause an E-box gel shift when the cells were stimulated to differentiate in culture, but not under basal conditions.


Input: The combination of ICP47 and US11 rendered fibroblasts negative for surface class I MHC and allowed a class I MHC-low population of T cells to be sorted by flow cytometry.

surface class I MHC

class I MHC


Input: The recovery of adults schistosomes by extracorporeal filtration.


Input: Biochemical studies and studies of cells expressing mutant IL-2 receptors indicate that IL-2-induced tyrosine kinase activation initiates a complex signaling cascade.

IL-2 receptors

tyrosine kinase


Input: Serum levels of angiotensin converting enzyme were well maintained.

angiotensin converting enzyme


Input: We tested the effects of antifungal drugs on adherence of Candida albicans in vitro.


Input: The sections were stained with anti-polymorphonuclear leukocyte antibody, the endothelial marker factor VIII-related antigen, and with hematoxylin and eosin.

factor VIII-related antigen


Input: Portions of the 3'-coding and 3'-untranslated regions were found to be missing from the 7. 2-and 4. 8-kb topo II alpha mRNAs by Northern blot analysis.

7. 2-and 4. 8-kb topo II alpha mRNAs


Input: The combined in vitro effects of ethanol wih methaqualone, phenobarbital, pyrazole or disulfiram were studied using rat brain microsomal NA-K-ATPase.

rat brain microsomal NA-K-ATPase


Input: An analogue of calcium, strontium chloride Sr 89 is rapidly cleared from the blood after i. v. injection.


Input: These mutants, assayed by injection into Xenopus oocyte nuclei, delimit the promoter to 36 bp of DNA upstream of the cap site and 73 bp of the untranslated mRNA leader.


Input: The ARE is loosely defined as the five-nucleotide sequence AUUUA embedded in a uracil-rich region.


Input: The essential oil composition of three Zingiberaceae widely used as medicinal aromatic plants from S.


Input: (3) With the exception of the anteroposterior direction of layers II--III and the mediolateral direction of layer IV, the vertical conductivity of the cortex was always greater than either of the horizontal conductivities.


Input: Acad.


Input: To obtain information on the functional role of the Rac1/p38/MAPKAPK-2 pathway in RA signaling, the effects of pharmacological inhibition of p38 on RA-induced gene transcription and cell differentiation were determined.


Input: A regulatory element of the empty spiracles homeobox gene is composed of three distinct conserved regions that bind regulatory proteins.

empty spiracles


Input: CONCLUSIONS: The MC/UA ratio improves the sensitivity for the prediction of poor perinatal outcome when it is combined with the NST.


Input: Together with previous work our results suggest that C/EBP may be a general cooperation partner for v-Myb in myelomonocytic cells.

C/EBP

v-Myb


Input: Evolution of cytomegalovirus antibodies of maternal origin and acquired, throughout the first year of life


Input: IENF density at the calf was lower than that obtained from skin at more proximal sites, indicating the length dependency of small-fiber loss in these neuropathies.


Input: The sequence contained five repeats of the hypothetical leucine zipper motif: one is in the N-terminal globular domain, and four are in the central alpha-helical stalk.


Input: This paper reports estimates of the prevalence of mental retardation and associated factors based on a population survey of 2-to 9-year-old children in Greater Karachi, Pakistan.


Input: Zta stimulated the HAT activity of CBP that had been partially purified or immunoprecipitated from mammalian cells as well as from affinity-purified, baculovirus expressed CBP.

Zta

HAT

CBP

CBP


Input: Previous studies using partial sequences have suggested the potential of 26S or large-subunit (LSU) rDNA for phylogeny retrieval at taxonomic levels comparable to those investigated with 18S rDNA.

large-subunit

LSU

18S rDNA


Input: P53 mutations also offer new approaches to the study of the origins of mutations in human cancer.

P53 mutations


Input: Due to significant homology to the C-terminus of the Mutator transposase this alternative gene product was named Trap (transposon-associated protein).

Mutator transposase

Trap

transposon-associated protein


Input: RT-PCR analysis of FGFR-3 mRNA showed the presence of a splice variant in which exons 7 and 8 are deleted.

FGFR-3 mRNA


Input: A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.

serine kinase


Input: CYP51P1 is 96. 5% identical to the human CYP51 coding sequence and is not interrupted with introns but has six in-frame stop codons resulting from point mutations.

human CYP51


Input: Patients with risk factors were compared with those without risk factors.


Input: Mutations in glnB, nifR1 (ntrC), and NifR4 (ntrA encoding sigma 54) had no influence on put gene expression.

glnB

ntrC

ntrA

sigma 54

put gene


Input: This bud morphology results at least in part from a cell cycle delay imposed by the Cdc28p-inhibitory kinase Swe1p.


Input: IgE-binding proteins of Psocoptera were determined by immunoblotting experiments.

IgE-binding proteins


Input: 174, 233-247) and Serrate (Serrate1 and 2; Myat, A., Henrique, D., Ish-Horowicz, D. and Lewis, J., 1996.


Input: A new technique for the identification of phases contained within a polymer blend is described in this paper.


Input: Nonlethal sec71-1 and sec72-1 mutations eliminate proteins associated with the Sec63p-BiP complex from S. cerevisiae.

sec72-1 mutations

BiP


Input: Our studies indicate no single trans-acting factor is absolutely essential for enhancer activity, and that the enhancer activity of MerI is mediated via a combinatorial and additive mechanism.

MerI


Input: We recently reported the cloning and sequencing of the alpha 7 integrin chain and its regulated expression during the development of skeletal muscle (Song et al.

alpha 7 integrin chain


Input: Analytical scanning isoelectrofocusing.


Input: A structural model for Vpu is proposed in which the membrane anchor precedes a region comprising two amphipathic alpha-helices of opposed polarity, joined by a strongly acidic turn that protrudes into the cytoplasm and contains the CK-2 phosphorylation sites.

Vpu

CK-2 phosphorylation sites


Input: Primer extension analysis and subcloning of the virJ-phoA fusion indicate that the acetosyringone-inducible promoter lies directly upstream of the virJ structural gene.

virJ

phoA

virJ structural gene


Input: This novel TRPC7 gene could be a candidate gene for genetic disorders such as bipolar affective disorder, nonsyndromic hereditary deafness, Knobloch syndrome, and holoprosencephaly, which were mapped to this region.

TRPC7 gene


Input: In the future, transoesophageal echocardiography may be used to measure variations in wall thickness which change the global loading conditions in the basal midwall compartments of the left ventricle.


Input: METHODS: A discriminant function predicting surgery outcome (seizure-free vs. non-seizure-free) was computed separately for samples of patients with left (n = 79) and right (n = 62) temporal lobectomy (LATL, RATL).


Input: A porcine model of diffuse axonal injury, developed with information from these physical models and earlier in vitro tissue modeling studies, is used to correlate histologic and radiologic evidence of axonal injury to predicted regions of injury from the experimental and theoretical analysis.


Input: Control of ovulation in mares in the early breeding season with ovarian steroids and prostaglandin.


Input: The aim of this study was to determine the response properties of the human visual cortex to chromatic stimuli using magnetoencephalography (MEG).


Input: By subtractive and differential screening, we have cloned 12 of these sequences, 2 of which were c-fos and krox-24.

c-fos


Input: Basal level expression was reduced to 20 and 50% when the UGA stop codon was replaced by UAG or UAA, respectively, consistent with the finding that in E. coli translation terminates more efficiently at UAG and UAA than at UGA.


Input: The root-mean-square deviation of bond lengths from the ideal values is 0. 02 A.


Input: Sugar analysis was performed on alpha-TM to investigate a possible biosynthetic mechanism for part-time PGs.

alpha-TM


Input: To our knowledge no transcription factors have previously been identified that exhibit androgen-dependent expression in the epididymis.


Input: Proceedings: Influence of halothane on mortality from murine hepatitis virus (MHV3).


Input: Prevalence of rheumatic diseases in a rural population in western India: a WHO-ILAR COPCORD Study.


Input: Finally, in samples obtained from two patients with drug refractory ALL, BAC-derived probes applied to archived marrow cells demonstrated that a breakpoint occurred between MDR1 and sequences 500-1000 KB telomeric to MDR1, consistent with a random chromosomal rearrangement.


Input: We conclude that clonidine 3 micrograms/kg produces sedation comparable to diazepam 0. 2 mg/kg and also attenuates the intubation response without increasing the incidence of complications.


Input: The other regions include potential binding sites for transcription factors ATF, NF1, and a CCAAT-binding protein.

ATF

CCAAT-binding protein


Input: The analysis predicted that progressive increases in serum creatinine or aspartate transaminase activity will result in only a 50% reduction of clearance.

aspartate transaminase


Input: 5 Intravenous prizidilol hydrochloride decreases resting blood pressure and left ventricular area, increases pulse rate and has virtually no effect on left ventricular ejection fraction.


Input: The Saccharomyces cerevisiae targets of rapamycin, TOR1 and TOR2, signal activation of cell growth in response to nutrient availability.


Input: This 50-kDa protein contains two SH2 domains and an inter-SH2 domain of p85alpha, but the SH3 and bcr homology domains of p85alpha were replaced by a unique 6-amino acid sequence.

SH2 domains

inter-SH2 domain

bcr homology domains


Input: Gene structure and precursor processing.


Input: This effect is independent of the Gal4 protein, as it operates in a gal4 mutant background as well.

Gal4 protein

gal4 mutant


Input: Thus, d-delta3-carene was about four times more potent as a sensory irritant than I-beta-pinene, whereas the difference with I-alpha-pinene was more marked; as a sensory irritant, I-alpha-pinene is almost inactive.


Input: Blood and whole-brain mercury concentrations were determined in pups on PN 0 (birth) and PN 21 (weaning).


Input: Multiple copies of this binding site are found in the viral genomes.


Input: Tubular dysfunction in renal lithiasis: cause or consequence?] To investigate whether overall tubular dysfunction is encountered in a particular subgroup of patients with urolithiasis, the following parameters of renal tubular function have been measured in fasting morning urine in 124 male stone formers: excretion of lysozyme and gamma-glutamyl transpeptidase (gamma-GT), fractional excretion (FE) or glucose, insulin, bicarbonate after an alkali load, and theoretical phosphate threshold (TmP/GFR).

lysozyme

gamma-glutamyl transpeptidase

gamma-GT

insulin


Input: The blood pressures in 43 subjects were compared during rapid weight loss and at identical weights during post-fast weight gain (Study A).


Input: Mol.


Input: Arg-130, Gly-132 and Lys-167 are conserved in all members of the type IB topoisomerase family.

type IB topoisomerase family


Input: The maximal rise in plasma adrenaline was of similar magnitude in all three groups but a lower plasma glucose was required to stimulate this hormonal response in the' unaware' patients, in whom the plasma adrenaline concentration was lower at the time of the reaction.


Input: PATIENTS--125 women consulting the general practitioner for symptomatic bacterial vaginosis.


Input: Patients with advanced ovarian carcinoma, Stage III or IV (International Federation of Gynaecology and Obstetrics), were randomized to primary chemotherapy with doxorubicin (Adriamycin) and cisplatin plus or minus hexamethylmelamine, and cyclophosphamide (CHAP).


Input: Promoter activity of the proliferating-cell nuclear antigen gene is associated with inducible CRE-binding proteins in interleukin 2-stimulated T lymphocytes.

proliferating-cell nuclear antigen gene

CRE-binding proteins

interleukin 2


Input: Sequence analysis revealed 100% homology of all RA-derived PTEN fragments to those from normal SF as well as to the published GenBank sequence (accession number U93051).

PTEN fragments


Input: The mutation also preferentially limits (compared with total protein synthesis) translation of an induced gene that depends on five AGA codons, i. e., the lambda cI repressor gene.

lambda cI repressor gene


Input: The influence of a high n-3 PUFA intake on measures of lipid peroxidation has been equivocal.


Input: In contrast, inhibition of MAPK activity by MAPK kinase inhibitor (PD 98059) or by overexpression of kinase-deficient MAPKs activated basal and GnRH-A-stimulated GnRHR-Luc activity.

MAPK

MAPK kinase

MAPKs

GnRH-A

GnRHR

Luc


Input: For the first, short-term (concurrent) TAL, two different-flavored stimuli were presented at the same time, one associated with simultaneous intragastric administration of an aversive product, hypertonic NaCl, and the other with saline.


Input: CONCLUSIONS: LHB is simple, easy and safe to implement, and is the only technique capable of maintaining independent upper and lower body perfusion pressure.


Input: Heterodimerization mutant RXR failed to alter GFP-VDR and nlsGFP-VDR distribution or activity.

Heterodimerization mutant RXR

GFP

VDR

nlsGFP

VDR


Input: New TB respirator standards mean more choices at less cost.


Input: After first strand cDNA synthesis from fetal brain mRNAs, short fragment cDNAs (sf-cDNAs) were synthesized with a two-step amplification system by use of our modified Degenerate Oligonucleotide Primed Shuttle Polymerase Chain Reaction (DOP-Shuttle-PCR) method.


Input: Fulminant hepatic failure in these cases could be characterized by: (1) rapid decrease in serum alanine transaminase (ALT) level after discontinuation of ecarazine, (2) prolonged jaundice despite discontinuation of ecarazine, (3) high incidence of anti-nuclear antibody (ANA) (57%), and (4) histological findings of extensive hepatocellular necrosis ranging from bridging necrosis to massive necrosis.

serum alanine transaminase

ALT

anti-nuclear antibody

ANA


Input: Smectic-A ordering at a liquid-vapor interface.


Input: Simulation results based on the presented model are compared with the experimental data for two types of cMUTs reported in the recent literature.


Input: These results demonstrate that the entire E3L gene is required for pathogenesis in the mouse model.

E3L gene


Input: Parelaphostrongylus odocoilei is redescribed from worms collected from the type host (Odocoileus hemionus columbianus) in California, as well as material from experimentally infected mule deer (O. h. heminus) in Alberta.


Input: Sodium dodecylsulfate polyacrylamide gel electrophoresis (SDS-PAGE) showed two bands of about the same intensity with apparent molecular masses of 24. 5 and 22. 5 kDa.


Input: Particle bombardment of barley aleurone with a B22EL8 promoter-GUS (beta-glucuronidase) construct demonstrates that the promoter (3 kb) is active in developing barley grains.

B22EL8 promoter

GUS

beta-glucuronidase


Input: The cloning of CWH43 showed that it corresponds to YCR017c and encodes a protein with 14-16 transmembrane segments containing several putative phosphorylation and glycosylation sites.


Input: They elicit similar regional cerebral blood flow (rCBF) patterns, even though sign language is dependent on spatial information.


Input: However, at the time of salvage treatment, the mean serum PSA levels were 9. 1 and 1. 1 ng/mL for the salvage RP and salvage RT groups, respectively (P = 0. 0001).

serum PSA


Input: First, a GATA-1 motif was found to bind nuclear factor (s), presumably the GATA-1 factor, present in K-562 cell extracts and in living K-562 cells.

GATA-1 motif

GATA-1 factor


Input: There was a direct proportional relationship between the spiral artery flow and the pressure difference between the spiral artery and the amniotic fluid; the pressure difference per flow (the resistance of the cotyledonary unit) was found to be 1--3 mm Hg. ml-1. min (8--24kPa. ml-1. s).


Input: Truncations from Hip' s N terminus resulted in an apparent loss of Hip homo-oligomerization, but these mutants retained association with hsp70 and were recovered in receptor complexes.

Hip

Hip


Input: An oligomer synthesized to this region of homology produced two DNA-protein complexes with oviduct nuclear proteins.


Input: The myeloid zinc finger gene 1 (MZF1) encodes a C (2) H (2) zinc finger transcription factor that regulates granulopoiesis and may have a regulatory role in cellular proliferation and oncogenesis.

myeloid zinc finger gene 1

C (2) H (2) zinc finger transcription factor


Input: The rate of collagen synthesis in normal scar was approximately constant between 6 months and 20 years after the initial wounding, but in both hypertrophic scar and keloid the rate was initially approximately twice that in normal scar, and 2-3 years after wounding it fell to approximately the same level as in normal scar.

collagen


Input: When phentermine was mixed with other unlabeled reversible MAO inhibitors (e. g. pseudoephedrine, ephedrine, norephedrine; estradiol benzoate), the degree of MAO inhibition was additive.

MAO

MAO


Input: W., and Touster, O.


Input: There was a 57% reduction in IGF IR mRNA levels in clone CA9 after confluence compared with clone ME10.

IGF IR mRNA


Input: Uncoupling gene activity from chromatin structure: promoter mutations can inactivate transcription of the yeast HSP82 gene without eliminating nucleosome-free regions.

yeast HSP82 gene


Input: Heating had no effect upon either force decline or slowing of relaxation during fatiguing contractions.


Input: Uncertainty exists about the function of these potential isoforms of the Cbfa1 gene.

Cbfa1 gene


Input: The RTI40 gene spans 35 kilobase pairs; it contains 6 exons and at least 6 rat Identifier repetitive elements.

RTI40 gene


Input: The characteristics of a simple apparatus for clinical use to measure DEOAEs are described together with typical examples of emissions.


Input: Anatomical considerations in transsphenoidal hypophysectomy.


Input: It has been confirmed in animal experiments that the number of microspheres in a myocardial sample approximately follows a Poisson distribution, under adequate experimental conditions.


Input: Maximal exercise duration and peak oxygen consumption were not changed.


Input: Hard methacrylic polymers.


Input: Validity of the short-form QIF was assessed by correlation with motor scores and using analysis of variance by motor levels and motor score groupings.


Input: An 81-nt tandem duplication of the C-terminal coding region is located adjacent to the termination codon of the CyIIIb gene, a potential relic of a slipped mispairing and replication event.

CyIIIb gene


Input: During seed maturation, the transcriptional activity of napin genes is regulated by developmental signals involving the transcriptional activator ABI3 and abscisic acid (ABA).

napin genes

transcriptional activator ABI3


Input: Here we report the cloning, by either peptide sequencing or by sequence similarity to the human cDNAs, of the S. cerevisiae genes RFC1, RFC2, RFC3, RFC4, and RFC5.


Input: On the other hand, V3 " values were not significantly correlated with the degree of tremor, seborrhea, and duration of the illness.


Input: The isomerization of the pre-existing closed complex to an open promoter form, as judged by the local denaturation of promoter DNA which rendered sequences from + 5 to-10 reactive towards KMnO4, was shown to be fully dependent on NifA.

NifA


Input: Mouse macrophage beta subunit (CD11b) cDNA for the CR3 complement receptor/Mac-1 antigen.

Mouse macrophage beta subunit (CD11b) cDNA

CR3 complement receptor

Mac-1 antigen


Input: The predicted product exhibits 91% amino acid identity to the murine voltage-gated potassium channel protein Kv1. 7 (Kcna7), which plays an important role in the repolarization of cell membranes.

murine voltage-gated potassium channel protein Kv1. 7


Input: Elective replacement of the aortic root in Marfan' s syndrome.


Input: Principles of thyroid hormone treatment


Input: Their main representatives are the American diagnostic and statistical manual of mental disorders, DSM-III, its revised version DSM-III-R and the new international classification of mental disorders iCD-10.


Input: Each received 20 mL of one of three test solutions: levobupivacaine control, levobupivacaine and fentanyl 2 microg/mL, or levobupivacaine and fentanyl 3 microg/mL.


Input: Time for action on hepatitis B immunisation.


Input: Kramer Hamburg 1988, ISBN: 3 926952 07 5), the syndromatic day-to-day shifting of the psychopathological features with manic, depressive and several mixed states has a well-defined time structure, as in 25 patients studied and reported on in this paper.


Input: Internal controls over the volume of milk suckled do not appear until infant rats are about 2 weeks of age at which time gastric distension, milk, systemic dehydration, and intestinal hormone cholecystokinin suppress milk intake derived through suckling.

intestinal hormone cholecystokinin


Input: In the HIV LTR, this region has been demonstrated to have both positive and negative regulatory effects on HIV gene expression.

HIV LTR


Input: Analysis of rat brain, heart, lung, liver, kidney and skeletal muscle revealed psi PKC zeta mRNA only in brain.

psi PKC zeta mRNA


Input: To identify and determine the function of Ino2p in yeast cells, we raised antibodies to a beta-galactosidase/Ino2 fusion protein.

beta-galactosidase


Input: In addition, WR-3689, WR-109342, and WR-168643 were used with per os administration to determine hematopoietic lethality.


Input: Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.

NOT


Input: Serum AFP is a useful tumor marker for monitoring the results of therapy.

AFP


Input: The paper calls for standardized question formats and a centralized body to monitor changes in these parameters of sexual behaviour.


Input: A heterologous promoter construct containing three repeats of a consensus Sp1 site, cloned upstream of a single copy of the ZII (CREB/AP1) element from the BZLF1 promoter linked to the beta-globin TATA box, exhibited phorbol ester inducibility.

Sp1 site

ZII

CREB

BZLF1 promoter

beta-globin


Input: A long-term follow-up study of a children' s psychiatric day treatment center.


Input: Risk factors for atherosclerosis related to nutrition are hypercholesterolemia, hyperglycemia-diabetes, and for hypertension, obesity, high salt intake, and excessive use of alcohol.