Input: We evaluated 99mTc-ECD SPECT comparing with rCBF images obtained by PET in 12 patients with spinocerebellar degeneration (SCD).


Input: Nimodipine (5 micrograms/kg) followed by infusion of 0. 75 microgram/kg/min lowered the blood pressure by 10% in both normotensive and hypertensive rats; the same dose schedule of nifedipine did not lower MAP.


Input: When severe hypoxia was acutely produced by ventilation with low-oxygen mixtures in experimental (PaO2, 23. 7 +/-1. 7 torr) and control animals (PaO2, 26. 3 +/-1. 0 torr), plasma insulin responses were markedly inhibited in both.

plasma insulin


Input: We have raised antibodies against a peptide specific to the predicted protein product of this second mRNA.


Input: Using unidirectional PCR we isolated a 361-bp 5' promoter region and delineated the intronic/exonic boundaries which include a non-coding exon 1, a single intron, and a coding exon 2, a structure that is typical of genes of the RNase A superfamily.

RNase A superfamily


Input: Results of these studies indicate that binding of biotin to the protein results in protection of regions of the central domain in the vicinity of the active site and the C-terminal domain from chemical cleavage.


Input: The family histories were obtained from the parents.


Input: Absence of nitroso formation from (14C) methomyl and sodium nitrite under simulated stomach conditions.


Input: The structure of the murine Dtk gene has been determined.

murine Dtk gene


Input: Outlook in oral and cutaneous Kaposi' s sarcoma.


Input: These data demonstrate that oleosin gene transcription is regulated in a tissue-specific and temporally regulated manner and clearly indicate that oleosin protein expression is co-ordinated primarily at the transcriptional level.

oleosin gene

oleosin protein


Input: Allergic field: how to detect it?


Input: The actual placement of the lesions was determined after mapping of the GPi by microrecording, using stimulation to identify the sensorimotor region and its somatotopic organization.


Input: The 0. 018-inch FloWire provides a high-fidelity continuous Doppler signal.


Input: Other recommendations for enhancing the safety of potent antiplatelet agents in a variety of clinical situations are provided.


Input: The concepts were developed by Mines and Garrey during the next 10 years.


Input: A new simple identification of rheumatoid factor on nitrocellulose was developed that allows quantitative detection.

rheumatoid factor


Input: Maximum overexpression of holoenzyme activity was achieved by the inclusion in such plasmids of Salmonella typhimurium cysG, which encodes a uroporphyrinogen III methyltransferase required for the synthesis of siroheme, a cofactor for the hemoprotein.

uroporphyrinogen III methyltransferase


Input: Determination of the LD 50 (30) during infant period and growth period


Input: Mutational analysis of yeast CEG1 demonstrated that four of the five conserved motifs are essential for capping enzyme function in vivo.

yeast CEG1

capping enzyme


Input: Purified phosphorylated PhoP (PhoPP) had a half-life of approximately 2. 5 h, which was reduced to about 15 min by addition of the same molar amount of * PhoR (the cytoplasmic region of PhoR).

PhoP

PhoPP

* PhoR

PhoR


Input: We conclude that exercise-induced ST-segment elevation in patients without a history of myocardial infarction or left ventricular aneurysm is caused by coronary spasm of a major coronary vessel.


Input: It spans 20 kilobases, consists of 7 exons and 6 introns, and contains a TATA motif 24 nucleotides upstream of the transcriptional start site.


Input: Metastatic tumours of bone in Nigerians.


Input: A survey of 274 late detected cases of CDH born in the years 1970--74 is presented.


Input: This distinct biochemical difference between STAT5A and STAT5B was confirmed with purified activated STAT5 recombinant proteins.

STAT5 recombinant proteins


Input: Enoxacin has been shown to be an effective well tolerated and convenient treatment for gonorrhoea.


Input: METHODS: Precision and accuracy were measured using controls and method comparison studies.


Input: Important prognostic factors for the results of physiotherapeutic exercises in intermittent claudication


Input: Thus, Tax1 activates CArG-mediated transcription without mitogenic signals through interaction with a CArG-binding factor, p67SRF.

CArG-binding factor


Input: In 5 cases, combined sensitization to mercury and other metal salts, particularly gold sodium thiosulfate (GST) and palladium chloride (PDC), was observed.


Input: Amongst 53 " inoperable " (T4, N0, N1, T., N2, N3) cases, 5 (10%) had a positive scan and 5 a doubtful scan.


Input: Acyclovir (3% ointment) used topically one to five times a day on acute ocular HSV infection gave beneficial results as measured by a reduction in corneal involvement, conjunctivitis, iritis, and corneal clouding.


Input: The efficiency of transfections was normalized relative to the net amount of CAT plasmid actually transfected into recipient cells, determined by a modified Southern hybridization procedure.

CAT


Input: Initial computer based similarity searches identified human retinoblastoma binding protein 1 (RBP-1), Drosophila melanogaster male specific lethal-3 (Msl-3), S. pombe altered polarity-13 (Alp13) and S. cerevisiae Eaf3p, a component of the yeast NuA4 HAT complex (Galarneau et al., 2000.

human retinoblastoma binding protein 1

Drosophila melanogaster male specific lethal-3

S. pombe altered polarity-13

S. cerevisiae Eaf3p

yeast NuA4 HAT


Input: These aa residues correspond to codons 59 and 108 in the P. falciparum DHFR active site in which similar aa substitutions (Cys Arg-59 and Ser Asn-108) are associated with pyrimethamine resistance.

P. falciparum DHFR active site


Input: Efficacy was evaluated in 24 patients, of whom eight received RD and 16 SD.


Input: Short-term growth: rhythms, chaos, or noise?


Input: Sequences homologous to the consensus TUF-binding UAS boxes are present in the 5' flanking regions of both genes.

TUF-binding UAS boxes


Input: Residues crucial for Ras interaction with GDP-GTP exchangers.

Ras

GDP-GTP exchangers


Input: The gene atp6, encoding subunit 6 of the mitochondrial F0-ATPase complex, has been characterized from both the normal (fertile) and Ogura (male-sterile) radish cytoplasms in order to determine if previously identified atp6 transcriptional differences could play a role in cytoplasmic male sterility.

gene atp6

ATPase


Input: To determine whether the transcript encodes an active enzyme, we developed a novel transient embryonic excision assay in which zebrafish fertilized eggs were co-injected with RNA transcribed in vitro using the Tol2 cDNA as a template and a plasmid DNA harboring a nonautonomous Tol2 element, which has a deletion in the transposase coding region.

Tol2 cDNA

Tol2 element

transposase coding region


Input: The expression of CAPL, a second protein involved in calcium metabolism, was only moderately elevated in the doxorubicin-resistant cells.

CAPL


Input: The reconstituted enzyme binds DNA with an affinity that is approximately 20-fold lower than that of the intact topo70.


Input: In late October, 1974, Staphylococcus aureus postoperative wound infection was recorded in a nonhuman primate (Macaca mulatta) which had recently undergone surgical operation.


Input: Thus, the in vivo function of Gle2p is strictly coupled to the short GLEBS within Nup116p which links this putative mRNA transport factor to the nuclear pores.

GLEBS


Input: Seminal prolactin levels were significantly elevated in all infertile males.

prolactin


Input: The recruitment of constitutively phosphorylated p185 (neu) and the activated mitogenic pathway proteins to this membrane-microfilament interaction site provides a physical model for integrating the assembly of the mitogenic pathway with the transmission of growth factor signal to the cytoskeleton.

neu


Input: The pattern of net RNA expression in adult mouse tissues is different.

net RNA


Input: Effect of capsaicin on hexobarbital-anesthetized rats


Input: Expression of human complement receptor type 2 (CR2/CD21) is primarily restricted to mature B cells and follicular dendritic cells.

human complement receptor type 2


Input: A physical and genetic map covering the entire RP12 candidate gene region was constructed.

RP12 candidate gene region


Input: We found that in premature infants plasminogen levels are low; thus, defense against intra-alveolar fibrin deposition during birth trauma is reduced.

plasminogen

fibrin


Input: Progestins: present and future.


Input: Indeed, DEX also enhanced the RA-dependent increase in RARbeta mRNA in a cycloheximide-sensitive manner.

RARbeta mRNA


Input: In both immortalized and normal diploid human cells, wt AAV targeted integration to ch-19.


Input: It was found that both versions of the brief SL & amp; shy; ASIA had similar correlations to the target variables as the full scale SL & amp; shy; ASIA.


Input: These operons encode subunits of photosystems I (psa) and II (psb), the cytochrome bGf complex (pet), the plastid NAD (P) H dehydrogenase (ndh), and the unidentified open reading frame ycf9.

photosystems I

psa

psb

cytochrome bGf complex

pet

NAD (P) H dehydrogenase

ndh


Input: In contrast, dominant negative Rac (N17Rac1) inhibited JNK activation by Galpha12 in HEK293 cells as well as three other cell lines.

dominant negative Rac

JNK


Input: A major feature of this genomic sequence is the presence of a first intron (Il), 215 bp long, located 48 bp downstream of the translation start ATG codon.


Input: We reviewed the different published cases of acute high dose methotrexate neurotoxicity and the different underlying mechanisms.


Input: The expected products of the cloned bph genes, except bphA3, were observed in E. coli in an in vitro transcription-translation system.

bph genes


Input: The immunoreactive antithrombin III increased significantly while the increase in antithrombin III activity was insignificant in 20 male Caucasian Danes upon 3 weeks supplementation of the diet with 10 ml daily of a cod liver oil concentrate.

antithrombin III

antithrombin III


Input: Only the 27-kDa protein was detected after N-glycosidase treatment, indicating that PLP-H is a glycoprotein.

N-glycosidase

PLP-H


Input: These observed changes were not found when assessing NPY level in plasma fluid.

NPY


Input: In three other patients the electrophysiologic characteristics of atrioventricular conduction prevented a demonstration of these differences.


Input: These sequence differences are reflected in differences in gene expression in three cell lines.


Input: The 10 eyes injected with human RPE cells showed STAGE 2 or less in 4 weeks.


Input: The cumulative dose to nursing staff for the week after treatment was dependent on patient mobility and was estimated at 0. 08 mSv for a self-caring patient to 6. 3 mSv for a totally helpless patient (1840 MBq/group A).


Input: The analysis consisted of 1) fitting first-and second-order autoregressive models (AR1 and AR2) and 2) obtaining the power spectra of the data by fast-Fourier transform.


Input: Of 921 specimens, 95 yielded non-albicans species, mainly from patients with low CD4 lymphocyte counts and extensive previous azole exposure.


Input: Sequence analysis and electrophoretic mobility shift experiments suggest that GnSE response elements interact, in these two regions, with GATA-and LIM-related factors, respectively.

GnSE response elements

GATA-and LIM-related factors


Input: The NrfC polypeptide, M (r) 24, 567, contains 16 cysteine residues arranged in four clusters typical of the CooF super-family of non-haem iron-sulphur proteins.

NrfC polypeptide

M (r) 24, 567

CooF super-family


Input: Hamdija Karamehmedovic; Ibn al-Nefis, " Mudzez al-Kanum ", Republicki zavod za zdravstvenu zastitu Sarajevo, 1961, 1-219; Mr ph Samuel Elazar, Ajnija Omanic: " Bibliografija medicinskih djela u SR BiH do 1895. " Medicinska knjiga Beograd-Zagreb 1984; Besides, the great contribution in bibliography was given by dr Lujo Taler, prof. dr.


Input: Patients randomized into the active treatment groups A30 (n = 49) and A60 (n = 48) received topical treatment with 3. 0% diclofenac in 2. 5% hyaluronan gel 0. 5 g twice daily for 30 or 60 days, respectively.


Input: Southern blot analysis performed on genomic DNA demonstrated altered CpG methylation within intron 1 in DNA from all BCC compared to normal, mortal human mammary epithelial cells (HMEC).


Input: In addition, both inhibitors blocked phosphatidylcholine hydrolysis and protein kinase C translocation.

protein kinase C


Input: Human PDNP3 is expressed in glioma cells, prostate, and uterus, but not in the alimentary tract.

Human PDNP3


Input: 13: 961-969, 1993) suggested that T antigen could mediate transcriptional activation through interaction with the TATA-binding protein, as well as upstream bound transcription factors.

T antigen

TATA-binding protein


Input: Identification of a putative infC-rpmI-rplT operon flanked by long inverted repeats in Mycoplasma fermentans (incognitus strain).

infC

rpmI

rplT


Input: IgE antibody to twelve common food and inhalant allergens was measured by enzyme-linked immunosorbent assay (ELISA) in the sera of thirteen atopic patients with one or more allergic disorders (asthma occurring in eleven; rhinitis in ten; eczema in six; urticaria in four; mouth and gastro-intestinal symptoms in six), of twelve non-atopic patients with various clinical symptoms (asthma in four; rhinitis in four; eczema in one; urticaria in two; mouth and gastro-intestinal symptoms in four) and sixteen cord blood sera.

IgE antibody


Input: Analysis of 1 Mb of published sequence from the region of conserved synteny on human chromosome 5q31-q33 identified 45 gene candidates, including 35 expressed genes in the human IL-4 cytokine gene cluster.

human IL-4 cytokine gene


Input: These p21-E2F complexes, while present in young G1 cells at very low levels, were elevated in senescent cells.


Input: The delta Mo + SV tumor DNAs from B-lineage tumors were typically rearranged at the immunoglobulin gene loci and contained germ line configurations of the T-cell receptor beta gene.

immunoglobulin gene loci

T-cell receptor beta gene


Input: An increased incidence of ATN has been reported since the introduction of cyclosporin A.


Input: Earlier reports have localized mutations which affect the processing and transport of herpes simplex virus 1 glycoproteins to a region located between the genes specifying glycoprotein B and the major viral DNA-binding protein (beta 8).

glycoprotein B

beta 8


Input: Magnetic force and torque at 1. 5 T did not dislodge the GF or result in perforation of canine IVC by the GF.


Input: The rec8 (+), rec10 (+), and rec11 (+) genes of the fission yeast Schizosaccharomyces pombe exhibit similar specificities for meiotic recombination and rec8 (+) is required for sister chromatid cohesion and homolog pairing.

rec8 (+)

rec10 (+)

rec11 (+) genes of the fission yeast Schizosaccharomyces pombe

rec8 (+)


Input: Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade.

PKC

MAPK


Input: The formation of a D-loop is an essential step in DNA double-strand break repair through recombination.


Input: Using a set of sera for which full chlamydial micro-immunofluorescence results suggested a clear diagnosis, we have evaluated the Chlamydia Spot-IF test (bioMerieux), which allows a comparison of titres to Chlamydia trachomatis and C. psittaci antigens.

Chlamydia trachomatis and C. psittaci antigens


Input: ET-1 limited the electrocardiographic evidence of subendocardial ischemia and attenuated contractile dysfunction compared with mechanical stenosis at the same coronary flows, even though lactate flux was similar.


Input: The AtNMT1 expression profile indicated ubiquity in roots, stem, leaves, flowers, and siliques (approximately 1. 7 kb transcript and approximately 50 kDa immunoreactive polypeptide) but a greater level in the younger tissue, which are developmentally very active.


Input: CONCLUSION: DMIPP detects regionally hypoperfused myocardium, in which agreement between MBF and fatty acid uptake deteriorates.


Input: The majority of putative TSC2 mutations were found in sporadic rather than TSC2-linked families.

TSC2 mutations


Input: Thirty-three small glottic carcinomas (T1 and small T2; UICC, 1978) were examined by malignancy grading using the 8-factor system proposed by Jakobsson et al.


Input: None of the 10 sequences has hitherto been recognized as part of the p53 signaling pathway.


Input: Studies in 26 patients.


Input: Transfection of H chain loss variant myeloma with the complete 12 kb construct, termed 238H-Cmicro, resulted in secretion of intact Ig pairing 238H-Cmicro, with a lambda L chain; however, transfectant Ig lacked autoreactivity and pathogenicity.

H chain loss variant

lambda L chain

transfectant Ig


Input: Comparison of the genes coding for mouse and human p36 (annexin II) and mouse, rat and human p35 (annexin I) and pigeon cp35 (an annexin I-related protein) shows strong genomic structural conservation supporting the hypothesis that these genes had a common ancestor.

annexin II

annexin I

annexin I-related protein


Input: Now: pleasure in work


Input: Cerumen management in hearing conservation: the Dallas (Texas) Independent School District program.


Input: Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres.

Polycomb-group gene Enhancer of zeste


Input: Xanthoepocin, a new antibiotic from Penicillium simplicissimum IFO5762.


Input: Additionally, VAHS is often associated with fatal infectious mononucleosis (IM).


Input: In addition, mutations within the Ubx unit exons are known and most of these behave as null alleles.

Ubx unit exons


Input: 273, 27420-27429) a putative peroxisome proliferator-activated receptor response element (PPRE) is present from-458 to-474.


Input: In T cells these two signal pathways are critical for interleukin-2 production.


Input: These results induce that the putative TATA box and initiator are not involved in the promoter activity, and that the vitronectin promoter lacks the TATA box, initiator and GC box.

vitronectin promoter


Input: Both residues are conserved in the three phosphorylated paralogs but are absent in the ones that were not substrates of RsbT: YetI and YezB, each of which bears only one of the conserved residues; and YtvA, which lacks both residues and instead possesses an N-terminal PAS domain.

RsbT

YetI

YezB

YtvA

PAS


Input: The role of PORT in the treatment of N2 tumours is not clear and may justify further research.


Input: The TDx assay for cyclosporine and its metabolites in blood samples compared with HPLC and RIA methods.


Input: This is consistent with the need for a nuclear retinoid receptor function in RA-induced ERK2 activation.

retinoid receptor


Input: It was previously shown that Vi antigen expression was regulated by a system similar to the rcs regulatory system involved in colanic acid synthesis in Escherichia coli.

Vi antigen

rcs


Input: However, the molecular mechanisms by which specific cis-and trans-acting factors control activity of the prodynorphin promoter are not as clearly defined.

prodynorphin promoter


Input: The gene set in this mitochondrial genome is a subset of that of Reclinomonas americana, an amoeboid protozoan.


Input: The library will thus be useful for the selection of cosmid clones which carry CDC genes from yeast by complementing first, with the vectorial yeast gene URA1, the pyrimidine auxotrophy of most cdc-strains and then, with the respective CDC wild-type genes, of the temperature-sensitive mutant alleles.

CDC genes from yeast

yeast gene URA1

cdc

CDC wild-type genes


Input: A plasma cell-rich infiltrate was present in the connective tissue cores of the papillae.


Input: Peptide competition studies have localized a cyclin A interaction site to a Lys381Lys382Leu383Met384Phe385 sequence within C-terminal negative regulatory domain of human p53.

cyclin A interaction site

human p53


Input: A phase II study was initiated to evaluate the effect of a combination of the pure L-isomer of LV and 5-FU along with epirubicin in patients with advanced pancreatic cancer.


Input: Attenuated serum cortisol responses were found in six of the patients despite a normal ACTH test.

ACTH


Input: While some still automatically refuse all patients with positive mediastinoscopy, most authors still remain very interventionistic for N2 patients selected on very accurate criteria that are analyzed above.


Input: Inability of niacin to protect from in vivo hyperoxia or in vitro microsomal lipid peroxidation.


Input: Sesame seed should also be considered a cause of allergic reactions to drug products and cosmetics.


Input: In absence of i. m. medication, levels over 1, 000 U must be carefully screened in order to rule out SNM or organic pathology associated.


Input: A yeast mitochondrial translation initiation codon mutation affecting the gene for cytochrome oxidase subunit III (COX3) was partially suppressed by a spontaneous nuclear mutation.

cytochrome oxidase subunit III


Input: Patients with endocarditis or vascular infection were more frequently immunocompromised and older than those with acute Q fever.


Input: This latter complex reacts with an antibody to serum response factor (SRF) and exhibits the same binding characteristics as purified SRF.

serum response factor

SRF

SRF


Input: MEASURES: SF-36 questionnaires were completed by patients at both initial and discharge examinations.


Input: Hormonal replacement therapy for women with a personal history of breast cancer?


Input: The human SHBG proximal promoter was analyzed by DNase I footprinting, and the functional significance of 6 footprinted regions (FP1-FP6) within the proximal promoter was studied in human HepG2 hepatoblastoma cells.

human SHBG proximal promoter

DNase I


Input: Endodontic treatment of deciduous teeth using the formocresol amputation method


Input: The analysis of results suggests that seroprevalence of Lyme borreliosis in dogs of the Kosice region is not negligible.


Input: Mutant beta2-adrenergic receptors with a Tyr-to-Phe substitution at Tyr-350 do not display agonist-induced desensitization, Src recruitment, or Src activation.

beta2-adrenergic receptors

Src

Src


Input: The feasibility of creating CR1/Ig chimeras makes possible a new strategy of targeting complement inhibition by the use of Ig fusion partners having particular antigenic specificities.

Ig

Ig fusion partners


Input: Otosclerosis in monozygotic twins: clinical and genetical analysis


Input: The results show that in uninfected NIH-3T3 cells Avarol (i) causes a 50% reduction of the growth rate only at the high concentration of 29. 6 microM and (ii) is accumulated in the cytoplasm close to the nucleus.


Input: Furthermore, disruption of pcr1 reduced expression of fbp1, a glucose-repressible gene negatively regulated by PKA.

PKA


Input: This B-box is not present in ETS1, ETS2, PEA3 or PU. 1 and these proteins were unable to form ternary complexes with SRF and Egrl-SREs or c-fos SRE.

PU. 1

SRF

Egrl

c-fos


Input: Excretion of radiopharmaceuticals into breast milk.


Input: It is concluded that the drinking ampules of VP-16-213 can be replaced with the new oral capsules with a recommended initial dose of 100-130 mg/m2 given in 5-day courses every 21-28 days.


Input: Deletion of the region from amino acid residues 2-67 in E1A, which has been postulated to interact with p300/CBP, also abolished the inhibitory effect of E1A, whereas deletion of the region from residues 120 to 140 had no effect.

CBP


Input: It was found that on the 14th and 21st day after cimetidine administration serum gastrin levels were significantly elevated.

serum gastrin


Input: Both PMP20 gene products contain the carboxyl-terminal sequence AKL, similar to the putative SKL peroxisomal sorting sequence (Gould, S.

PMP20 gene products


Input: After cumulative occlusions of 15, 30, 45, and 90 min, transmural needle biopsies were taken from the ischemic area to be analyzed for adenine nucleotides, nucleosides, creatine phosphate, and ultrastructural changes.


Input: We found both the v-Ras-and PC-PLC-transformed cells to be insensitive to stimulation with platelet-derived growth factor (PDGF).

v-Ras

PC-PLC

platelet-derived growth factor

PDGF


Input: Although indomethacin is useful for examining the role of cyclooxygenase products in asthmatic responses, it should not be considered in the treatment of asthma.

cyclooxygenase products


Input: Furthermore, it was found that the Shb-overexpressing cells extended neurites in response to epidermal growth factor.

Shb

epidermal growth factor


Input: Tre during exercise at 35 W at 23 degrees C correlated r =-70 with Vo2max and r = 0. 80 with Tre during exercise in heat.


Input: Therapeutic iodine 125 for hyperthyroidism: evidence for a special radiobiological effect on the follicular cell.


Input: The biological activity of these mutants was tested by determining their capacity to (i) reconstitute RNA polymerase activity in vivo by cotransfection with proteins NP, PB1, and PA and a virion-like RNA encoding the cat gene into vaccinia virus T7-infected COS-1 cells and (ii) complete with the wild-type PB2 activity.

RNA polymerase

NP

PA

cat

wild-type PB2


Input: Should we use thiazide diuretics in hypertensive patients with non-insulin-dependent diabetes mellitus?

insulin


Input: It appears that the K-ABC is a relatively nonbiased test suitable for the evaluation of both gifted and nongifted children regardless of race or gender.


Input: The University of North Carolina caries risk assessment was conducted between 1986 and 1989 with 5000 children initially in grades 1 and 5 from low fluoride sites in South Carolina and Maine.


Input: Treatment of cells for 10 min with TNF-alpha resulted in activation of p44/42 MAPK, p38, and JNK.

TNF-alpha

JNK


Input: The coding region of nifA was determined using a translational lacZ fusion and by site-directed mutagenesis to identify which of four in frame AUG codons was used.

nifA

lacZ fusion


Input: In phase II studies, MDL 72, 974A is proving to be a useful adjunct to conventional therapy.


Input: A derived RA-resistant line, NT2/D1-R1, is deficient in this activity and is co-resistant to cisplatin.


Input: These studies reveal that CREM, a tissue-specific factor, is expressed and regulated by gonadotropins in the ovary, that the predominant CREM transcripts encode the repressor protein ICER, and that ICER is capable of inhibiting cAMP-induced expression of the inhibin alpha-subunit gene.

CREM

gonadotropins

CREM

repressor protein ICER

ICER

inhibin alpha-subunit gene


Input: A small molecule ILK inhibitor suppresses the phosphorylation of PKB at the Ser-473 but not the Thr-308 site in the PTEN mutant cells.

ILK

PKB

PTEN


Input: Menstrual and lunar cycles.


Input: Phenacetin nephritis


Input: Both claR and car are expressed as monocistronic transcripts; the level of transcript declined rapidly after 48h in complex media, but low sustained levels of both transcripts were observed in defined GSPG medium until 96h. claR and car were not significantly expressed in mutants disrupted in the ccaR gene, a regulatory gene that controls positively clavulanic acid and cephamycin biosynthesis.

claR

car

claR

car

ccaR gene


Input: Viral complementary 15 S mRNA that directs the synthesis of N protein and hybridizes to the predicted N gene DNA has been identified in infected cell extracts.

15 S mRNA

N protein

N gene


Input: Experiments were performed without polarization or with cathodic and anodic polarization of the adsorbent.


Input: Our results suggest that Sp1 binding site can function as a distinct TGF-beta responsive element for TGF-beta mediated promoter expression and Sp1 per se can mediate this response.

Sp1 binding site

TGF-beta responsive element

TGF-beta


Input: A positive correlation was also established between the level of FP9C binding and the degree of cell differentiation in vitro.


Input: In another patient, IRPF recurred in the ureter of a living related renal graft 6 months after transplantation.


Input: Similar to the D, B/B' and E proteins, the F and G proteins do not possess any of the known RNA binding motifs, suggesting that other types of RNA-protein interactions occur in the snRNP core.

D

B

B'

E proteins

F

G proteins


Input: Ultrasound-guided fine-needle aspiration biopsy (US-FNAB) revealed normal-looking squamous cells.


Input: HC-toxin exerts a potent cytostatic effect on plant and animal cells by inhibiting histone deacetylase.

HC-toxin

histone deacetylase


Input: In EGF receptor-mediated signaling, the protein kinase PKB/Akt and the mitogen-activated protein kinase c-Jun N-terminal kinase, but not extracellular signal-regulated kinase 2, function downstream of phosphatidylinositol 3-kinase (PI 3-kinase).

EGF receptor

protein kinase PKB

Akt

mitogen-activated protein kinase c-Jun N-terminal kinase

extracellular signal-regulated kinase 2

phosphatidylinositol 3-kinase

PI 3-kinase


Input: Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152).


Input: On the basis of this homology, we examined the potential role of c-Rel in controlling IL-2R alpha transcription.

c-Rel

IL-2R alpha


Input: Site-directed mutagenesis shows that sites throughout the IRE alter negative control and IRE-BP binding reflecting the fact that the footprint of the IRE-BP is over the entire IRE.

IRE

IRE-BP

IRE-BP

IRE


Input: However, LXRalpha inhibited binding of PPARalpha/RXRalpha heterodimers to PPREs, and coexpression of LXRalpha in mammalian cells antagonized peroxisome proliferator signaling mediated by PPARalpha/RXRalpha in vivo.

LXRalpha

PPARalpha

RXRalpha

LXRalpha

PPARalpha

RXRalpha


Input: In clinical stroke cardiovascular abnormalities are frequently neglected although they occur more often than it is generally assumed.


Input: Complementary DNA libraries from liver and ovary of an immature female channel catfish were screened with a homologous ERalpha cDNA probe.

homologous ERalpha cDNA


Input: Examination of the Coomassie-stained gels revealed that the capsid-like particles composed of the N11-VP1 protein did not contain any host-derived histones.

histones


Input: Here we show that one nudF suppressor also suppresses hs-mutations in nudA, nudC, and nudG and deletions in nudA and nudF.

nudF suppressor

nudA

nudC

nudG

nudA

nudF


Input: Thus, the potential induction of this gene rearrangement by E1A gene therapy is unlikely to be clinically significant in the treatment of advanced malignant disease.

E1A gene


Input: Our results suggest that Bry1/Skn7 can influence the expression of MCB-and SCB-driven gene expression in budding yeast, perhaps including genes involved in cell wall metabolism, via a two-component signal transduction pathway which activates Bry1/Skn7 in response to an unidentified signal.


Input: Buspirone therapy for Type A behavior, hostility, and perceived stress in cardiac patients.


Input: When furA alone was introduced into the Delta (furA-katG) mutant, survival in mouse lungs was moderately increased, suggesting that FurA could regulate genes, other than katG, that are involved in pathogenesis.

furA

furA

katG

FurA

katG


Input: The resulting threshold elevation curves fell into a small number of distinct groups, suggesting the existence of discrete spatial frequency mechanisms in human central vision.


Input: Through interactions with the pre-mRNA and the CTD domain of the Polymerase II, SR proteins have been shown to regulate alternative splicing.

Polymerase II

SR proteins


Input: The screen identifies mutants whose growth depends on high levels of expression of that gene.


Input: Electrophoretic mobility shift analysis of protein-DNA complexes formed with nuclear proteins isolated from I3C-treated and-untreated cells, in combination with supershift assays using Sp1 antibodies, demonstrated that the Sp1-binding site in the CDK6 promoter forms a specific I3C-responsive DNA-protein complex that contains the Sp1 transcription factor.

Sp1 antibodies

Sp1-binding site

CDK6 promoter

Sp1 transcription factor


Input: It is suggested that the mechanism of intestinal absorption of vitamin D and 25-hydroxy-vitamin D may differ in man, the absorption of 25-hydroxy-vitamin D possibly being less dependent on bile acids.


Input: In a study in Singapore, Chinese, Malay and Indian patients with pulmonary tuberculosis received 2 months of daily treatment with streptomycin, isoniazid, rifampicin, and pyrazinamide followed by daily isoniazid, and rifampicin either with pyrazinamide (SHRZ/HRZ) or without it (SHRZ/HR), allocated at random.


Input: However, C/EBP beta stimulated transcription primarily through the cAMP-responsive element (CRE), which maps between positions-77 to-94, but not at the more 5'-binding sites.

C/EBP beta


Input: Helenalin triggers a CD95 death receptor-independent apoptosis that is not affected by overexpression of Bcl-x (L) or Bcl-2.

CD95 death receptor

Bcl-x (L)


Input: The observed alterations in lung functions in these subjects indicate that individuals performing heavy continuous exercise are more likely to be affected by lower O3 levels.


Input: Shields needed for pacemakers.


Input: A nationwide record linkage of the Finnish Twin Cohort Study (FTCS) with the Hospital Discharge Registry and the Registry of Rights for Free medication is presented.


Input: Results demonstrated that for both S. europaea and A. prostrata, the total number of seeds that germinated decreased throughout the growing season.


Input: A personal view of future trends in the field of immunoassay concludes this review.


Input: Our results admit that a ribosome scanning mechanism of the MP gene expression from I (2) sgRNA operates concurrently.

MP gene


Input: This study demonstrates that Fluosol significantly attenuates neutrophil adherence, cytotoxicity, and enzyme release in an in vitro model of microvascular injury.


Input: 22. 6% of patients were found to be positive at histology in the corpus mucosa; all but one of these patients had elevated circulating IgG to H. pylori (Group C).

IgG


Input: Concerning the practical approach in a clinical setting, it has to be pointed out that with these diseases a hepatitis C infection has to be considered and testing for hepatitis C antibodies and, if positive, hepatitis C-RNA is indicated.

hepatitis C antibodies

hepatitis C-RNA


Input: In order to investigate the effect of the local direct action of danazol upon endometriosis, intravaginal and intrauterine application were tried.


Input: Western blot experiments detected SMBP as a 70 kDa protein that may be further cleaved into an active 34 kDa N-terminal polypeptide.

SMBP


Input: 80 bp) surrounding the site of transcription initiation.


Input: A backward look at urinary tract infections.


Input: All the cognate gene clones were constructed, using either PCR products amplified from genomic DNA, or gap-repair.


Input: On Western blots, the same antibodies recognized the recombinant protein migrating slightly slower on SDS/PAGE than chicken axonin-1.

chicken axonin-1


Input: BCR-ABL elicits transformation of both fibroblast and hematopoietic cells and blocks apoptosis following cytokine deprivation in various factor-dependent cells.

BCR

ABL


Input: The transcriptional transactivator (Tas) of simian foamy virus type 1 strongly augments gene expression directed by both the promoter in the viral long terminal repeat and the newly discovered internal promoter located within the env gene.

transcriptional transactivator

Tas

env gene


Input: Analysis of nt sequence was carried out on three out of the more than 15 of these regions present in the mouse genome.


Input: Moreover, site-specific integration of the ITR-flanked DNA was also detected by PCR amplification of the ITR-aavs1 junction in transduced human fibroblasts.

ITR-aavs1 junction


Input: Finally, we demonstrate that animals carrying a snf mutation that converts SNF from a bifunctional protein to a U1 snRNP-specific protein are viable.

snf

SNF

U1 snRNP-specific protein


Input: For this interaction, the C-terminal part of Sp1 and the N terminus of E2F1, a domain also present in E2F2 and E2F3 but absent in E2F4 and E2F5, were essential.


Input: To gain additional insights into this novel apoptotic checkpoint, we have now characterized the mouse survivin locus.

mouse survivin locus


Input: Since RIP140 generally down-regulates receptor activity in mammalian cells and specifically down-regulates coactivation mediated by SRC-1, we propose a model in which RIP140 indirectly regulates nuclear receptor AF-2 activity by competition for coactivators such as SRC-1.

nuclear receptor AF-2


Input: We constructed a stable, doubly transfected cell line (TIS-10) carrying a chromosomally integrated ptetO7-CMV-L reporter construct and expressing the TetR-KRAB protein.

TetR

KRAB


Input: Value of bone scintigraphy with Tc99MDP in the early diagnosis of mobilization of the total hip prosthesis


Input: Coimmunoprecipitation analysis suggests that these residues likely contribute to the multimerization function required for homomeric complex formation or heteromeric complex formation with p50 in that no association of p65 delta with itself or with p50 was evident.

p65 delta


Input: The isolation of crt5-262, an additional cdc allele of POL1/CDC17, suggests for the first time that directly blocking DNA replication can provide a signal to induce the DNA damage response. crt2 mutants show a defect in basal level expression of RNR1-lacZ reporter constructs.

cdc allele

crt2 mutants

lacZ


Input: Denaturing gradient gel electrophoresis (DGGE) with sequence analysis showed that PGCL4 is a major member in the female mammary gland, and in the submaxillary and lachrymal glands of both sexes, while the counterpart in male liver and the coagulate glands was found to be PGCL1.


Input: Five sequence variants were identified.


Input: If failure to solve invisible displacements was due to increased memory requirements, then the primates should perform at chance level on all 3 problems.


Input: Mouse GRK6-C displays none of these motifs.

Mouse GRK6-C


Input: The cumulative length of the RGSV genome, including RNAs 5 and 6, was 25142 nt.


Input: CTDK1 and CTDK2 also differ in their protein substrate specificity.


Input: ATF is formulated from the prothrombin time (PT), fibrinogen transformation rate (FTR) (a representation of thrombin activity), and a consideration of the fibrinogen (FBG) content of blood plasma.

prothrombin

fibrinogen

thrombin

fibrinogen

FBG


Input: Protease digestion and alkaline extraction of microsomes containing labeled mutant proteins further showed that segment 3 was sufficient for stable membrane anchoring of the glycoproteins, indicating that this segment may specify the transmembrane domain of the gB glycoprotein.

gB glycoprotein


Input: Peripheral visual acuity with monovision and other contact lens corrections for presbyopia.


Input: ORF3 appears to encode the homologue of the well-conserved proteasomal 26S regulatory subunit.

proteasomal 26S regulatory subunit


Input: 87, 7270-7274).


Input: Protein binding to UAS1MLS1 was observed with extracts from derepressed but not from repressed cells, and could be competed for by an excess of the unlabelled CSRE (ICL1) sequence.


Input: This inhibition was due to competition from the EMC virus IRES present in pEP-2A transcripts, as well as the expression of proteolytically active 2Apro.

pEP-2A transcripts


Input: These properties prompted us to investigate Ets-1 expression in 32 human astroglial tumors of WHO grades I-IV and to correlate the data with the expression pattern of VEGF, Flt-1, and KDR.

VEGF

KDR


Input: The CydDC system appears to be the first prokaryotic example of a heterodimeric ABC transport system in which each polypeptide contains both hydrophobic and ATP-binding domains.

CydDC system

heterodimeric ABC transport system


Input: Ionic composition (Na +, K +, Ca + 2, and Mg2 +) of cerebrospinal fluid and feeding behavior in sheep.


Input: Recently we have performed a detailed analysis of specific neuronal populations affected by the mutation which shed new light on the role of Krox-20 in the segmentation and on the physiological consequences of its inactivation.


Input: Comparison of the sequences of the alpha-like DNA polymerases including E. coli DNA polymerase II showed that there were nine highly conserved regions, and we constructed an unrooted phylogenetic tree of the DNA polymerases based on the differences in these conserved regions.

alpha-like DNA polymerases

E. coli DNA polymerase II

DNA polymerases


Input: Guanylyl cyclase C, the apparent guanylin receptor, was found in abundant amounts in the intestine by Northern analysis, and by the polymerase chain reaction or cDNA cloning it was also found in adrenal gland, airway epithelial cells, brain, and olfactory and tracheal mucosa.

Guanylyl cyclase C

guanylin receptor


Input: Older females had lumbar (0. 6 +/-1. 3) and TB (1. 1 +/-1. 1) BMD Z scores greater than 0 (both, p < 0. 001).


Input: Mutation of the distal E2F binding site in the cdc25A promoter abolished E2-induced repression, whereas mutation of the proximal E2F site or the E2 site had no effect.

E2F binding site

cdc25A promoter

E2F site

E2 site


Input: Psychopathological, vegetative, and vital parameters were assessed every hour.


Input: A new family of rate-adaptive pacemakers accomplishes this circadian rate variation by modeling the patient' s sleep-wake cycle using a time-of-day clock inside the device.


Input: New strategies are needed to prevent coronary rethrombosis in patients with minimal atherosclerosis after thrombolytic therapy for acute myocardial infarction.


Input: METHODS AND RESULTS: With an array of 112 unipole, epicardial maps of electrically induced AF in 6 dogs (acute group), self-sustained AF in 6 dogs (chronic group), and sinus rhythm and atrial pacing in 3 dogs (control group) were analyzed before and after creating linear radiofrequency ablation lesions in both atria that eliminated the AF.


Input: The mitochondrial tyrosyl-tRNA synthetase of Podospora anserina is a bifunctional enzyme active in protein synthesis and RNA splicing.

mitochondrial tyrosyl-tRNA synthetase


Input: We found that the central nonconserved region of the large subunit is not essential for function and likely acts as a spacer between the conserved N-and C-terminal regions.


Input: Further comparative analysis identified an ADNP paralog (33% identity and 46% similarity), indicating that these genes belong to a novel protein family with a nine-zinc finger motif followed by a homeobox domain.

ADNP


Input: Surprisingly, apo-iso-1-cytochrome c is absent in cyc3-strains, although apo-iso-2-cytochrome c is present at approximately the same level at which holo-iso-2-cytochrome c is found in CYC3 + strains.

apo-iso-1-cytochrome c

apo-iso-2-cytochrome c

holo-iso-2-cytochrome c

CYC3 +


Input: A role for phosphatidylinositol 3-kinase in the regulation of beta 1 integrin activity by the CD2 antigen.

phosphatidylinositol 3-kinase

beta 1 integrin


Input: The cluster was mapped to nucleotides-464 to-434 (relative to nucleotide A in the initiation codon) in genomic DNA.


Input: All the previously mapped structural protein-encoding genes of phage LL-H were included in the sequence.


Input: An exception is the Bcl-6 gene, encoding a transcription factor, which was found to be mutated in normal human memory B cells.

Bcl-6 gene


Input: Nature and incidence of conditioned responses in a methadone population: a comparison of laboratory, clinic, and naturalistic settings.


Input: Serum PRL concentrations significantly increased after MCP administration in normal women, hyperprolactinemic patients with normal sella and patients with microadenoma, but not in macroadenoma patients with and without suprasellar expansion (SSE).

PRL


Input: Fourteen Centers participated in this trial.


Input: In cells stably transfected with G alpha i-2 or G alpha i-3 gene 5'-flanking sequences fused to firefly luciferase cDNA reporter, temporal 10-15-fold transcriptional activation of both genes occurred before cellular polarization.

G alpha i-2

G alpha i-3 gene

luciferase


Input: A gene (FMR-1) was identified within a four cosmid contig of YAC DNA that expresses a 4. 8 kb message in human brain.


Input: These include not only antioxidants, N-methyl-D-aspartate receptor antagonists, inhibitors of glutamate release, calcium channel blockers, polyamine antagonists, and nitric oxide synthase inhibitors, but cannabinoids, aspirin, melatonin, and vitamin B-12.

N-methyl-D-aspartate receptor

nitric oxide synthase


Input: In conclusion, ANH had no negative effects on the endocrine stress response during orthopedic surgery under epidural anesthesia.


Input: Both genes ARO3 and ARO4 are strongly regulated under the general control regulatory system.

genes ARO3


Input: Calculation of energy levels, E1 transition amplitudes, and parity violation in francium.


Input: A homologue of the MAP/ERK family of protein kinase genes is expressed in vegetative and in female reproductive organs of Petunia hybrida.

MAP

ERK


Input: Significance of esophagocardiac reflexes for inducing thoracic pain


Input: Northern blot analysis confirmed that ADAMTS-1 was up-regulated in both metaphyseal (14-to 35-fold) and diaphyseal (4. 2-fold) bone 1 h after PTH-(1-38) injection and returned to control levels by 24 h.


Input: The findings in the human multiple myeloma cell lines represent the first examples of B cells with downregulated PU. 1 expression and apparently contradict observations in the murine system in which PU. 1 is expressed and active in plasmacytoma cell lines.

PU. 1

PU. 1


Input: Northern blot analysis identified retina-specific transcripts of 3. 0 kb for rod G alpha t and 2. 6 kb for cone G alpha t.

rod G alpha t

cone G alpha t


Input: The STP1 locus is located on chromosome IV close to at least two other genes involved in RNA splicing: PRP3 and SPP41.

STP1 locus


Input: Both sequence analysis and restriction fragment length polymorphism analysis revealed a high degree of sequence (97% homology) and structural similarity among members of the ART-CH family, indicating their common origin and recent penetration into chicken DNA.

ART

CH


Input: This interesting exon junction resulted in novel deduced amino terminal open reading frames, which are completely in-frame with sequences located further downstream.


Input: We investigated the pattern of evolution of bronchial albumin, IgA, and IgG levels in ventilated ICU patients in relation to nosocomial pneumonia.

albumin

IgA

IgG


Input: The presence of highly correlated frequencies provided strong evidence of a medium-frequency pattern generator which may remain operative beyond the neonatal period.


Input: Pancreatic expression of the glucagon gene depends on multiple transcription factors interacting with at least three DNA control elements: G1, the upstream promoter element, and G2 and G3, two enhancer-like sequences.

glucagon gene


Input: Before and 6 and 12 months after H. pylori eradication the patients were evaluated for fasting gastrinemia and pepsinogen I, basal and peak acid output, and detailed histological assessment including the ECL cell proliferative patterns.

pepsinogen I


Input: Thus, CARP is a YB-1 associated factor and represents the first identified cardiac-restricted downstream regulatory gene in the homeobox gene Nkx2-5 pathway and may serve as a negative regulator of HF-1-dependent pathways for ventricular muscle gene expression.

CARP

YB-1 associated factor


Input: Barium mucosal coating was judged to be better in the members to whom magnesium sulphate was administered (p = 0. 0007).


Input: Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A.

phosphotyrosyl phosphatase activator

PTPA

protein phosphatase 2A


Input: This article expands the analysis of a numeric example included in the SAS GLM procedure to cover several crucial statistical aspects relevant to ANCOVA, and to highlight the meaning of the statistical results obtained.


Input: The PEP4 gene was isolated from a genomic DNA library by complementation of the pep4-3 mutation.

PEP4 gene


Input: These results suggest that panretinal photocoagulation offers a highly effective means of dealing with early and moderately advanced cases of angle neovascularization.


Input: Bilateral renal oncocytoma in a Greyhound dog.


Input: Membrane depolarization is a critical element of neuronal signaling.


Input: The E. multilocularis/Mongolian gerbil system can replace the natural canid hosts as a new way to obtain infective eggs and to analyze host-parasite interactions.


Input: The Fugu rubripes (Fugu) gene fragment was used to isolate the GH gene from a Fugu genomic library.

GH gene


Input: For the first time also a genomic sequence for a red algal lhc gene is presented.

red algal lhc gene


Input: All such polypeptides containing 263 or more residues derived from the C-terminus of P130gag-fps (i. e. residues 920-1182) were enzymatically active as tyrosine kinases.

fps

tyrosine kinases


Input: Were this hypothesis correct, the requirement for elF4A should correlate with the degree of mRNA secondary structure.


Input: Comparison with the data of clinical development and hemodynamic results


Input: Localized Bicaudal-C RNA encodes a protein containing a KH domain, the RNA binding motif of FMR1.

Bicaudal-C RNA


Input: Despite a lowering of her plasma ACTH concentration during therapy with valproic acid, the patient' s tumour showed no evidence of regression while she was taking the drug.

ACTH


Input: This is the first report which clearly proved CEA synthesis in the cells of HCC.

CEA


Input: NASA CR-1223.


Input: The classic sterol regulatory cis element (sre-1) in the LDL receptor promoter mediates sterol regulatory element binding protein (SREBP)-binding and the effects of insulin and platelet derived growth factor (PDGF).

LDL receptor

sterol regulatory element binding protein

SREBP

insulin

platelet derived growth factor

PDGF


Input: The D443N substitution is an activating mutation that increases the activity of SCAP and renders it resistant to inhibition by 25-hydroxycholesterol.

D443N substitution

SCAP


Input: Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR.

anti-apoptotic protein BCL-XL

paired box transcription factors PAX3

FKHR


Input: 5. 3 +/-6. 6 for risperidone (P = 0. 09).


Input: CONCLUSIONS: This study shows that the annual rate of de novo aneurysm formation is relatively high (0. 89%) and that the cumulative risk becomes significant after 9 years.


Input: In this case myogenic factors are not initially expressed and these migratory cells are characterized by the expression of the paired-box gene Pax3.

paired


Input: In those patients who before transplantation were serological negative for CMV but had received organs from CMV-IgG positive donors, the incidence of the disease was highest.

CMV-IgG


Input: The fecal excretion is found to be only one third of that measured in urine.


Input: This ERD is recorded over the contralateral central region.


Input: We report the sequence of a 7941 bp DNA fragment from the left arm of chromosome VII of Saccharomyces cerevisiae which contains four open reading frames (ORFs) of greater than 100 amino acid residues.


Input: Tax was demonstrated to interact directly with CREB1 but not with other bZIP proteins, including CREB2 and Jun.

Tax

bZIP proteins

Jun


Input: Forty-five per cent of the dose was excreted as methyldopa as opposed to 18% normally seen after oral methyldopa dosages.


Input: Standing values: placebo 114/79; BHT-933 92/67.


Input: Zoonotic areas in which HIV co-infection is common could also be at risk as sandflies can become infected from co-infected individuals.


Input: In cases in which it was identified, insulitis affected 23% of islets containing insulin, but affected only 1% of islets which were insulin deficient, thus supporting the concept that insulitis represents an immunologically mediated destruction of insulin secreting B cells.

insulin

insulin

insulin


Input: Each fusion leads, in principle, to the same effect: The ret tyrosine kinase is uncoupled from its stringent physiological regulation by replacement of its 5' end and is aberrantly activated by the 5' parts of fused genes in thyrocytes that do not normally express ret tyrosine kinase.

ret tyrosine kinase

ret tyrosine kinase


Input: Proteins PBP-1 and PBP-2 bind to two of the three promoter elements in the trypanosomatid Leptomonas seymouri.


Input: Induction of interferon-alpha (IFNalpha) gene expression in virus-infected cells requires phosphorylation-induced activation of the transcription factors IRF3 and IRF7.

interferon-alpha

IFNalpha


Input: The differences of percentages for HIV-1 infection in intravenous drug users (IVDU) were 67. 7% and in non IVDU were 3. 8% with a significant statistical difference (chi 2 = 557. 5; p < 0. 0001).


Input: Humoral immunity is altered with the drop in IgG levels.

IgG


Input: The vicinity of large industrial emissions of lead, where mean Pb-B concentrations were usually twice as high as in rural areas of the Katowice voivodship.


Input: (control hearts).


Input: Thus, BCR ligation initiates a PI 3-kinase/Akt/GSK-3 signaling pathway.

BCR

PI 3-kinase

Akt


Input: Effect of a new positive inotropic agent (OPC-8212) on intracellular potential of isolated canine ventricular papillary muscle


Input: Although several other signal transduction molecules also contain tandemly occurring SH3 and SH2 domains, the function of these closely spaced domains is not well understood.

SH2 domains


Input: At the same acoustic power, the rate of chloride formation with 20 kHz ultrasound was greater when a probe with a larger tip area was used, but significantly less than the rate with 900 kHz.


Input: This is the first report demonstrating specificity at the level of the energy coupling proteins of the PTS.


Input: The R260A mutant, as expected, was unable to support mRNA synthesis in vitro in a transcription reconstitution reaction as well as transcription in vivo of a minigenome using a reverse genetic approach.


Input: As expected, the QOLS-N had a lower correlation with physical health (r = 0. 24, p < 0. 000) and self-reported symptoms (r =-0. 20, p < 0. 001), and a higher correlation with mental health (r = 0. 52, p < 0. 000).


Input: Human epidermal growth factor (EGF), a naturally occurring protein, has been implicated in the protection of gastrointestinal mucosal integrity.

Human epidermal growth factor

EGF


Input: Elevated potassium stimulation of GAL mRNA was completely blocked, but pituitary adenylyl cyclase-activating polypeptide and histamine stimulations were only partially blocked, by cycloheximide.

GAL mRNA

adenylyl cyclase-activating polypeptide


Input: DNA elements recognizing NF-Y and Sp1 regulate the human multidrug-resistance gene promoter.

NF-Y

human multidrug-resistance gene promoter


Input: We constructed a series of chimeric genes containing part of the first exon and increasingly longer 5' flanking sequences of the ODC gene fused to either bacterial chloramphenicol acetyltransferase (CAT) or luciferase reporter genes.

ODC gene

bacterial chloramphenicol acetyltransferase

CAT

luciferase reporter genes


Input: To investigate this possibility, we conducted split-visual-field studies in which we manipulated stimulus sets, recognition task, and exposure duration.


Input: Like pimethixene and cyproheptadine, WA 335 has no distinct antagonistic qualities against bradykinin.

bradykinin


Input: To explore the mechanism of insulin receptor phosphorylation we have used NIH3T3 cells transfected with two receptor constructs: one encoding a chimeric receptor composed of the extracellular domain of the human EGF receptor and the cytosolic domain of the human insulin receptor beta-subunit, and a second construct encoding a kinase-defiecient human insulin receptor.

insulin receptor

human EGF receptor

human insulin receptor beta-subunit

human insulin receptor


Input: Additional simulations account for interactions of spatial frequency with stimulus duration, effects of adaptation, and properties of residual traces, as opposed to visual persistence.


Input: A DNA fragment that complements the uvs-2 mutation was subcloned by monitoring its ability to transform the uvs-2 mutant to MMS resistance.

uvs-2 mutant


Input: This cell line expresses productively rearranged immunoglobulin genes as well as the Oct-2 gene at high levels which are comparable to those observed in activated murine splenic B cells.

immunoglobulin genes

Oct-2 gene


Input: Back-ground factors which affect the outcome of steroid withdrawal therapy in patients with chronic type B hepatitis--statistical evaluation of the importance of the mode of HBV transmission


Input: Effect of food on hemodynamics.


Input: PTP1-lacZ studies indicate that PTP1 is spatially localized to prestalk and anterior-like cell types.

lacZ


Input: Morphologic evidence that rhe renal calyx and pelvis control ureteric activity in the rabbit.


Input: Human alcohol dehydrogenase (ADH) exists as a heterogeneous group of isozymes capable of oxidizing a wide variety of aliphatic and aromatic alcohols.

Human alcohol dehydrogenase

ADH


Input: We reviewed 81 patients with dementia and autopsy findings of Alzheimer' s disease (AD) to identify patients with seizures or myoclonus after onset of dementia.


Input: The second system (VacFix) uses a 0. 15 mm thick plastic bag loosely filled with 1 mm polysterol spheres.


Input: Expression in all lines was decreased by the inclusion of regions further upstream, and extinguished by the inclusion of the first intron.


Input: These results indicate that the changes in the patient' s thyroid scan and RAIU were attributable to the presence of TSAb.


Input: U.


Input: A Laboratory Manual, 2nd ed.


Input: In the case of a moderate buccal Class II tendency, 55% of the molars were in a Class I relationship when evaluated from the lingual side, whereas 45% belonged to mild (1st degrees) Class II with molar rotations present in 81% of the cases.


Input: The resulting score, which allowed the disease to be expressed as a continuous variable, was effectively utilized to see the correlations between the severity of coronary arterial disease (CAD) and individual risk factors/risk markers.


Input: The gene encoding the cellulase (Avicelase) Cel1 from Streptomyces reticuli and analysis of protein domains.

cellulase

Avicelase


Input: A protein which promotes DNA strand transfer between linear double-stranded M13mp19 DNA and single-stranded viral M13mp19 DNA has been isolated from recA-E. coli.

recA-


Input: We speculate that the enhancing effect of glucose and galactose on fructose absorption may be due to activation of the fructose carrier.

fructose carrier


Input: The nutraceuticals of specific vitamins, minerals, phytoestrogens, and essential fatty acid supplementations are a vital component of the risk reduction health program.


Input: Thus, in V. furnissii, the E. coli manX equivalent comprises two genes, which are separated in the genome by two other genes of the ptsM complex.

E. coli manX equivalent

ptsM complex


Input: An scrR promoter fragment, which dose not contain a sequence resembling OB, was not shifted by the fusion protein.

scrR promoter fragment

OB


Input: Ectopic expression of cyclin D1 in progestin-inhibited cells led to the reappearance of the 120-kDa active form of cyclin E-Cdk2 preceding the resumption of cell cycle progression.

cyclin D1

cyclin E


Input: We screened an A. thaliana cDNA library, whose inserts are under the control of the galactose-inducible GAL10 promoter, for cDNAs which enabled YDH8 cells to grow at the restrictive temperature.

GAL10 promoter


Input: The mouse alpha A-CRYBP1 gene specifies a 2, 688-amino acid protein with 72% amino acid identity to its human homologue, PRDII-BF1.

mouse alpha A-CRYBP1 gene


Input: Sequence analysis revealed that Hv-p68 belongs to the large family of FAD-dependent glucose methanol choline oxidoreductases and that it shares significant sequence identity (> 67%) with the alcohol oxidases of the methylotrophic yeasts.

FAD-dependent glucose methanol choline oxidoreductases

alcohol oxidases


Input: Therefore, we have reevaluated the age-related changes in serum leptin levels and their relationship with adiposity and androgen levels in a large group of community dwelling men.

serum leptin


Input: The 1-year and 2-year survival rates for the patients with N0-3 significantly exceeded those of N4 patients.


Input: While reviewing gastric specimens from 215 baboons, we found diffuse giant mucosal folds in 2 specimens and multiple giant mucosal nodules in another 3.


Input: Morphologically, corrugation of the internal elastic lamina of vessels was often observed in the vehicle-treated group, but was not prominent in the GLNVA-treated groups or healthy controls.


Input: Transcripts initiating at the CAGT motif (proximal transcripts) were abolished by deletion of the proximal TATA box located at-29 relative to CAGT.


Input: The phenomena of nursing are deeply rooted in the human condition.


Input: Coronatine (COR) is a plasmid-encoded phytotoxin synthesized by several pathovars of phytopathogenic Pseudomonas syringae.

Coronatine

COR


Input: It has become clear that there is not one mediator responsible for ALI, but rather a complex interplay exists between diverse proinflammatory (e. g., lipopolysaccharide, complement products, cytocains, chemocains, reactive oxygen species and arachidonic acid products) and anti-inflammatory (IL-10, IL-1-RA, PGI2) mediators.


Input: Not only will it substantially reduce incident cases of hepatitis B for the next decade, it will also provide a framework for the successful introduction of future adolescent vaccine initiatives in Australia.


Input: Radioactively labeled microspheres were used to determine and compare the hemodynamic effects of sodium nitroprusside (SNP), nitroglycerin (NTG), and deep enflurane anesthesia on oral tissues during controlled hypotension when compared with controls.


Input: We conclude that the MMF lesion is secondary to intramuscular injection of aluminium hydroxide-containing vaccines, shows both long-term persistence of aluminium hydroxide and an ongoing local immune reaction, and is detected in patients with systemic symptoms which appeared subsequently to vaccination.


Input: Advisory Committee report recommends that US make amends for human radiation experiments.


Input: An evaluation of a positive control for platelet neutralization procedure testing with seven commercial activated partial thromboplastin time reagents.

thromboplastin


Input: Transmission of mutans streptococci to infants following short term application of an iodine-NaF solution to mothers' dentition.


Input: Glycoprotein biosynthesis in Saccharomyces cerevisiae: ngd29, an N-glycosylation mutant allelic to och1 having a defect in the initiation of outer chain formation.


Input: However, no consensus on indications exists and, according to the literature, results are contradictory.


Input: The effects of erythrosine (Red 3), rose bengal B (Red 105) and thyroidectomy on the development of thyroid tumor were examined in male Wistar rats treated with N-bis (2-hydroxypropyl) nitrosamine (DHPN).


Input: The region surrounding the ZNF35 zinc finger protein gene on 3p21 is of particular interest, as this region of chromosome 3 is frequently involved in rearrangements and/or deletions associated with various human tumors including lung and renal carcinoma.

ZNF35 zinc finger protein gene


Input: In contrast, no change in the level of either p53 or activation of mdm2 protein by p53 was observed in hamster UV61 cells after UV exposure.

mdm2 protein


Input: Complete activation of signal transducer and activator of transcription 1 (STAT1) requires phosphorylation at both Y701 and a conserved PMS (727) P sequence.

signal transducer and activator of transcription 1


Input: It is believed that the operation is effective because it cuts the spinothalamic tract (STT), a primary pathway carrying nociceptive information from the spinal cord to the brain in humans.


Input: On the basis of experiments with mutant virus and transfection with isolated genes, the herpes simplex virus immediate-early gene product ICP4 is known to positively regulate the transcription of viral early and late genes and negatively regulate expression from its own promoter.

herpes simplex virus immediate-early gene

viral early and late genes


Input: Alcohol abuse and treatment resistance in skin disease.


Input: These data suggest that reduction in PRA may have contributed to the hemodynamic effects of this peak III PDE inhibitor.

peak III PDE


Input: However, studies using the A20 promoter demonstrated that LMP1 transcriptionally activates the A20 gene through cis-acting kappa B sites.

A20 promoter

A20 gene

kappa B sites


Input: The first 270 bp of the promoter region were sequenced and found to contain a CATAA box rather than a TATAA box and several DNA motifs found in activation genes.


Input: This study investigated if signal-averaged low amplitude atrial potentials predict atrial fibrillation or flutter (AFF).


Input: The reduced expression caused by multimerization of UAS2 in the native promoter was observed only in the presence of ADR1.


Input: Finally, we tested whether activation by either of these factors is dependent on components of the SAGA complex.

SAGA complex


Input: One child, recently fed, vomited a small amount of breast milk after a short period of crying and apparently had a laryngospasm, shown by a sudden drop in the PtcO2 level without any other signs of discomfort.


Input: The central venous O2 saturation test in acute pulmonary fat embolism.


Input: Such unique recognition capabilities are generated with minimal alterations in the CDR3 loops of the TCR.

TCR


Input: Sequence comparisons reveal that the P. woesei GTP-binding protein is strikingly related in sequence to eubacterial FtsZ and is marginally more similar to eukaryotic tubulins than are bacterial FtsZ proteins.

P. woesei GTP-binding protein

eubacterial FtsZ

eukaryotic tubulins

bacterial FtsZ proteins


Input: Additional transection of both ADN eliminated the remaining sigmoidal correlation between MAP and RSNA with further increases in resting MAP and RSNA.


Input: Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes.

NF-kappa B

C/EBP


Input: FDP-1 (200 micrograms. kg-1) of intracoronary injection increased collateral flow, reduced systemic artery resistance, and coronary systolic pressure in infarcted region and the area of infarction decreased from 28. 9 +/-1. 3% to 15. 3 +/-1. 2% (P < 0. 01, n = 6).


Input: The results of these experiments indicated that charcoal, imbiber beads, and the anion exchanges resins, Dowex XFS-4022 and Dowex SBR-C1, would not be useful agents for increasing the amount of dieldrin eliminated via feces (droppings) of chickens.


Input: Neither raw nor retrograded resistant starch lowers fasting serum cholesterol concentrations in healthy normolipidemic subjects.


Input: A regression analysis showed that 86% of the variance in weight gain was predicted by two leading indicators in the middle phase of treatment.


Input: Heterologous hybridization with a rps12 gene specific probe from Euglena has revealed the presence of rps12 homologous sequences within the inverted repeat of Spirodela chloroplast DNA on the fragment BamHI-V.

rps12 gene

rps12 homologous sequences

fragment BamHI-V


Input: In 6 patients (9 kidneys) irrigation with Solution G in the renal pelvis was performed for the dissolution of their infectious stones.


Input: Derepression of RAR signaling by expressing a dominant-negative corepressor resulted in embryos that exhibited phenotypes similar to those treated by RA.

RAR


Input: Flux of the paramyxovirus hemagglutinin-neuraminidase glycoprotein through the endoplasmic reticulum activates transcription of the GRP78-BiP gene.

hemagglutinin

neuraminidase

BiP


Input: Within the final 11 amino acids there are 5 aromatic, 2 basic, and no acidic residues and it has been proposed that these residues stack with and electrostatically interact with the kinked DNA at the site of a pyrimidine dimer.


Input: The influence of different temperatures between 13 degrees C and 45 degrees C on coagulation factors in vitro was studied by measuring clotting time with the recalcification time, partial thromboplastin time (PTT), and thromboplastin time test.

thromboplastin

thromboplastin


Input: Recombinant propeptides containing mutations of one of the three tryptophan residues were three orders of magnitude less effective as inhibitors of mature cathepsin S than the wild-type propeptide.

mature cathepsin S


Input: Molecular cloning of cDNAs encoding alpha-subunits of guanine nucleotide-binding regulatory proteins (G-proteins) has revealed the existence of nine species of alpha-subunits.

guanine nucleotide-binding regulatory proteins

G-proteins


Input: In all cases, a large fraction of soluble Al became insoluble in the stomach after ingestion.


Input: The free fraction of amitriptyline (AT), measured by equilibrium dialysis in plasma from 29 AT-treated depressed patients, was 5. 4-9. 8% (mean 7. 7%), which was the same as the values in 26 healthy controls (4. 9-9. 6%, mean 7. 6%).


Input: The prominent fracture of women older than 75 years is the hip fracture (type II osteoporosis).


Input: AU-rich elements in the 3'-untranslated region of a new mucin-type gene family of Trypanosoma cruzi confers mRNA instability and modulates translation efficiency.

mucin-type gene


Input: Under anaerobic conditions (a 50-day experiment) these organisms degraded 15-18% of the TEM, 20-25% of some alkanes, and 15-18% of selected polycyclic aromatic hydrocarbons.


Input: They cause temporary disability, invalidity and mortality of a great part of the productive population, significantly damaging the economic status of the country.


Input: We then isolated the full-length coding region of the human BACH1 gene using expressed sequence tags, reverse transcription-polymerase chain reaction and rapid amplification of cDNA ends.

human BACH1 gene


Input: In addition, wild-type and mutated DNA templates were used as probes in DNase I protection experiments to determine sites of protein-DNA interaction.

DNase I


Input: CONCLUSIONS--Postlumbar puncture headache may be mediated by the release of substance P triggered by lumbar puncture, in patients predisposed to headache by a hypersensitivity to substance P.

substance P

substance P


Input: The repeats are highly conserved both within a given element as well as between different members of the family (less than 10% divergence).


Input: They are found to have several advantages over the conventional indices of skewness and kurtosis (square root of b1 and b2) and no serious drawbacks.


Input: Second, CGGA-containing sequences placed at-88 in the delta MTV-CAT reporter plasmid conferred insulin responsiveness to the mammary tumor virus promoter.

delta MTV-CAT reporter

insulin

mammary tumor virus promoter


Input: Hemorrheological evaluation and proposed pharmacological uses.


Input: Stimulation of the endosteal bone formation rate was mainly impaired in D-depleted rats, resulting in trabecular bone loss, which, in-D mother rats, was associated with decreased bone ash and total bone calcium.


Input: Biochemical status was examined using erythrocyte enzyme function and blood vitamin levels.


Input: The Polycomb group proteins are involved in maintenance of the silenced state of several developmentally regulated genes.

Polycomb group proteins


Input: Repeated interferon-beta (IFN-beta) silencer B motifs and a lysozyme silencer 1 motif have been found in the CD95 gene at approximately-1, 600 and-1, 100, respectively.

interferon-beta

IFN-beta

lysozyme silencer 1 motif

CD95 gene


Input: We find that Fus3p and Kss1p both control G1 arrest through multiple functions that operate in parallel with Far1p.


Input: The Id4 protein contains a HLH domain highly conserved among the dnHLH proteins from mouse and drosophila.

Id4 protein

dnHLH proteins


Input: The proliferative potential of the pilocytic astrocytoma: the relation between MIB-1 labeling and clinical and neuro-radiological follow-up.


Input: Desensitization of the growth hormone-induced Janus kinase 2 (Jak 2)/signal transducer and activator of transcription 5 (Stat5)-signaling pathway requires protein synthesis and phospholipase C.

growth hormone

Janus kinase 2

Jak 2

signal transducer and activator of transcription 5

phospholipase C


Input: The aim of our study was to determine whether exercise training can augment left ventricular diastolic filling at rest and during exercise in patients with ischemic cardiomyopathy and whether any correlation exists between changes in diastolic filling and changes in exercise tolerance.


Input: Alterations in TCR-MHC contacts subsequent to cross-recognition of class I MHC and singly substituted peptide variants.

TCR

MHC

class I MHC


Input: Scalp blood flow was recorded by a laser Doppler flow sensor that was incorporated in the transcutaneous PO2 electrode.


Input: There is an overall functional similarity between IL-6 and c-fos promoters, since transfection of excess amounts of either promoter DNA into intact HeLa cells modulates the function of the heterologous promoter construct.

c-fos promoters


Input: Detailed comparison of the sequences of cp35 and human calpactin II shows that the only substantial sequence dissimilarity is a domain encoding amino acids between residues 20 and 40 which includes a tyrosine phosphorylation site in the human molecule, along with other residues of possible physiological significance.

human calpactin II


Input: Power deposition by inverse-bremsstrahlung is modeled with a scheme based on Gaussian quadrature to accommodate a deposition rate whose spatial variation is highly nonuniform.


Input: However, the malaria vectors Anopheles funestus and An. gambiae have both become more abundant during the 1970s and 1980s and sporozoite-positive specimens of both have been found.


Input: Greer, and L. A.


Input: Expression of Msx-1 and Msx-2 has been studied during development of the osteoblast phenotype, but the role of Dlx in this context and in the regulation of bone-expressed genes is unknown.

Dlx


Input: The salt sensitivity of the interaction indicated that two ion pairs are involved in the association of Zn2 + (NC-F1) with polynucleotide, whereas one ion pair is found in the metal-free peptide-nucleic acid complex.


Input: Histopathologically, (mice killed with high doses of GMC-II, given orally) there were diffuse hyperemia of the liver, parenchymal degeneration of the kidney tubuli epithelium, and edema and emphysema of the lungs.


Input: Cytochemical and ultrastructural observations on the tegument of the trematode Megalodiscus temperatus.


Input: The overall rate of biohydrogenation of C18: 2 was 14. 3%/h, but declined 1. 2%/h for each percentage unit increase in C18: 2 added to the substrate.


Input: Transient thyrotoxicosis in primary anti-phospholipid syndrome.


Input: The highest TTX content is 10. 0 microg/g in N. livescens.

TTX


Input: The BUR was set at 20/min and the IT at. 5 seconds.


Input: In this study, to elucidate the possible mechanism of action of EM, we examined the effect of the drug on the expression of neutrophil adhesion molecules such as L-selectin and Mac-1.

L-selectin


Input: It contains 31 exons and a high proportion of class 0 introns, alternative splicing of which results in significant levels of variant transcripts that maintain the original open reading frame of MRP mRNA.

MRP mRNA


Input: This nuclear/organellar gene transfer event is strikingly similar to the experimentally accessible process of nuclear integration of introduced heterologous DNA.


Input: Under control conditions, pretreatment with lithium during 7 days did not modify the hyperlocomotion produced by d-amphetamine.


Input: We also show that the products of both the GIY-YIG ORF and the non-canonical LAGLI-DADG-GIY-YIG ORF, which is generated by its integration, have endonuclease activities which recognize and cut the insertion site of the optional sequence.

GIY-YIG

LAGLI-DADG-GIY-YIG


Input: This article describes a program that resulted in a 75-percent reduction of inventory over a five-year interval.


Input: Risk ratios decreased with increasing age and increased with number of breast biopsies, family history of breast cancer, estrogen use, time between screenings, no comparison with previous mammograms, and the radiologist' s tendency to call mammograms abnormal.


Input: The pharmacokinetics were best described by a two-compartment open model giving distribution half-lives of 0. 31 h and 1. 53 h, and elimination half-lives of 69. 7 h and 60. 3 h for oxolinic acid and oxytetracycline, respectively.


Input: However, the relative substrate specificity of RSK3 differed from that reported for other isoforms.


Input: This study demonstrates a novel link between alterations in platelet-derived growth factor (PDGF) regulation of ornithine decarboxylase (ODC) expression during malignant conversion.

platelet-derived growth factor

PDGF

ornithine decarboxylase

ODC


Input: Fosinopril decreased blood pressure from 174/101 mm Hg to 149/88 mm Hg in patients with diastolic hypertension and from 182/86 mm Hg to 151/80 mm Hg in patients with ISH.


Input: Loss of pRb or p107 binding results in the loss of transforming activity.

pRb


Input: Influence of huanglian used in combination with huangqin and gancao on the erythrocytic osmotic fragilitas of experimental glucose-6-phosphate dehydrogenase deficiency in rats] OBJECTIVE: To study the influence of common combination of Huanglian (Coptis chinensis) on the erythrocytic osmotic fragilitas of glucose-6-phosphate dehydrogenase (G6PD) deficiency in rats.

glucose-6-phosphate dehydrogenase

glucose-6-phosphate dehydrogenase


Input: Inhibitory receptors are characterized by the presence of a characteristic sequence known as an immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic tail.


Input: Comparison of Healon and Amvisc.


Input: 2, 4-and 2, 6-toluenediamine in hydrolysed plasma and urine after test-chamber exposure of humans to 2, 4-and 2, 6-toluene diisocyanate.


Input: The role of the medical facilities in the prognosis of the patient with tetanus specially the importance of considering at the same time the severity of the disease and the characteristics of the therapy deserve further study in order to contribute to the development of the medical assistance to the patients with tetanus.


Input: Interaction between the tobacco DNA-binding activity CBF and the cyt-1 promoter element of the Agrobacterium tumefaciens T-DNA gene T-CYT correlates with cyt-1 directed gene expression in multiple tobacco tissue types.

CBF

cyt-1 promoter element

T-CYT


Input: These results suggest that repetitive GAA sequences enhance splicing by binding a protein complex containing a sequence-specific RNA binding protein and a general splicing activator that, in turn, recruit additional SR proteins.

SR proteins


Input: Organization of exons suggests that, similar to the human VEGF gene, alternative splicing generates the 120-, 164-, and 188-amino acid isoforms, but does not predict a fourth VEGF isoform corresponding to human VEGF206.

human VEGF gene

VEGF isoform

human VEGF206


Input: The papers provide a broad perspective of MPAs and include social, economic, cultural, biological and statistical components.


Input: The great cardiac vein flow became zero due to the cardiac arrest and remained at zero for a moment (dead time) after the initiation of reperfusion.


Input: CONCLUSIONS: These results suggest that histamine-2 receptor activation mechanisms may not be involved in postoperative IL-6 synthesis.

histamine-2 receptor


Input: Issues discussed include the validity of the MMPI Mf scale, questions of sample representativeness, whether " straights " can do adequate research on homosexuality, differences in heterosexual and homosexual sexuality, the role of subculture acculturation in homosexual psychological adjustment, and the use of cluster-analysis to generate typologies of homosexualities.


Input: Our data suggest that some defects observed in BS, WS or RTS are the consequence of unrestrained recombination.


Input: LAC9 is a DNA-binding protein that regulates transcription of the lactose-galactose regulon in Kluyveromyces lactis.

lactose-galactose regulon


Input: Some cells were excited, others inhibited by, and only some were directionally sensitive to the optomotor stimulus.


Input: We have cloned the cDNA for the SLBP from humans, mice, and frogs, using the recently developed yeast three-hybrid system.

SLBP


Input: The molecular event (s) underlying the functional specificities of these receptors (in regulating the expression of their native target genes) is a very important issue that remains poorly understood.


Input: Alternative splicing of the human serotonin transporter gene.

human serotonin transporter gene


Input: Nuclear proteins bound the cad + 55/+ 75 element in a cell cycle-dependent manner in electromobility shift assays; antibodies specific to USF and Max blocked the DNA-binding activity of different growth-regulated protein-DNA complexes.

cad + 55/+ 75 element

USF

Max


Input: For Thermus strain ZO5 dihydroorotase (DHOase; encoded by pyrC), the highest similarity scores (about 40% identity) were obtained with DHOases from B. caldolyticus and Bacillus subtilis.

ZO5 dihydroorotase

DHOase

pyrC

DHOases


Input: This difference between SP-1 and SP-2 peptides was not due to their differential uptake by cell, since approximately 100 times more SP-2 peptide could be found in cytoplasmic extracts than SP-1 peptide in experiments using radiolabeled peptides.

SP-2 peptides

SP-2 peptide

SP-1 peptide


Input: The product of one gene, Bv80, has a single divergent copy of a sequence of 149 amino acids (approx.


Input: The carboxy-proximal regions of the VP1, which contain very low amino acid homology, displayed evidence of conservation in structural features such as a hydrophilic, highly basic domain.


Input: The sequences at-10 and-35 relative to the transcriptional starting site showed 55% homology with the consensus sequences of the Escherichia coli sigma 70-type promoter.

Escherichia coli sigma 70-type promoter


Input: The two ORFs had significant similarity with the putative replication protein from plasmid pTiK12 of Thiobacillus intermedius and other CoIE2-related plasmids.


Input: A clinical double-blind trial of topical miconazole and clotrimazole against superficial fungal infections and erythrasma.


Input: Lumbar spine bone mineral density (BMD) by dual-energy X-ray absorptiometry (DXA) increased by 0. 6%, 3. 6% and 8. 1% after 48 weeks in groups L, M and H respectively, responses in groups M and H being significantly higher than in L (p < 0. 05, Mann-Whitney U-test).


Input: A genomic clone representing the 5' part of the message was also isolated.


Input: This unusual behaviour may be explained by the 18 amino acid-long CDR-H3 and could be of value in the design of' single domain' antibodies.

18 amino acid-long CDR-H3


Input: Bleeding was successfully prevented in 28 patients with the use of a combined treatment incorporating IV desmopressin, an antifibrinolytic agent (tranexamic acid), and local methods (surgical glue and compression techniques).


Input: Northern blot analysis demonstrated that the genes are transcribed separately.


Input: CONCLUSIONS: Systemic factors that increase bone mineral density appear to be involved in the pathogenesis of ossification of the posterior longitudinal ligament, and these factors may be activated after middle age.


Input: FdsR purified to homogeneity after overexpression of fdsR in E. coli is a 130 kDa homotetramer binding to the fds control region located between the fdsR and fdsG genes.

FdsR

fdsR

fds

fdsR

fdsG genes


Input: Surgical methods in the treatment of rhinophyma.


Input: The adeno-associated virus type 2 (AAV-2) Rep78/Rep68 regulatory proteins are pleiotropic effectors of viral and cellular DNA replication, of cellular transformation by viral and cellular oncogenes, and of homologous and heterologous gene expression.


Input: We show here that Spb1p is able to bind [(3) H] AdoMet in vitro, suggesting that it is a novel methylase, whose possible substrates will be discussed.


Input: Low temperature (8 degrees C) impairs secretory activity, again independently of the photoperiod selected.


Input: These data suggest that weight gain or increased caloric intake, in contrast to its large effect on peripheral thyroid function, has relatively little effect on CNS TRH activity.

CNS TRH


Input: Hematopoietic progenitor kinase 1 (HPK1) is a member of the mitogen-activated protein kinase kinase kinase kinase (MAP4K) family and an upstream activator of the c-Jun N-terminal kinase (JNK) signaling cascade.

Hematopoietic progenitor kinase 1

mitogen-activated protein kinase kinase kinase kinase

c-Jun N-terminal kinase

JNK


Input: We conclude that the outcome of patients with uterine MMMT is mainly influenced by the initial stage and the type of epithelial component.


Input: Increased susceptibility of aphasics to a distractor task in the recall of verbal commands.


Input: Here we show that inhibition occurs with a NS1-Rev chimera in which the 78 amino-terminal amino acids of the NS1A protein comprising its entire RNA-binding domain is deleted, thereby establishing that this carboxyl portion of the NS1A protein can function as an independent effector domain.

Rev

NS1A protein

NS1A protein


Input: We hypothesized that conjugated estrogens, which contain several vasoactive estrogenic compounds, may favorably influence the vasomotor response to acetylcholine in men.


Input: Calcium bilirubinate crystals were seen in gallbladder bile or wall scrapings of 7 of 8 TPN animals but in none of the controls (P less than 0. 001).


Input: Because c-myb encodes a transcriptional activator that functions via DNA binding, it is likely that c-myb exerts its biological activity by regulating the transcription of genes required for DNA synthesis and cell cycle progression.

c-myb

c-myb


Input: Alcohol and stomach diseases


Input: Thus integration host factor is required for normal type 1 fimbriae phase variation in E. coli.

integration host factor

type 1 fimbriae


Input: Multiple attempts aimed at disruption of the chromosomal fabG gene were unsuccessful.

chromosomal fabG gene


Input: In our case the development of the tumor at the posterior side of the prostate, the lack of PSA immunoreactivity and the presence of mucinous glands, sometimes " endocervical-like ", could suggest an origin from embryonic mullerian remnants in the prostatic utricle rather than urogenital sinus.

PSA


Input: Analysis of the DNA-binding and transcriptional activation functions of human Fli-1 protein.

human Fli-1 protein


Input: The second patient was successfully treated with intravenous prostaglandin F2 alpha (PGF2 alpha).


Input: Salts of these four metal ions may be added to the growth medium to facilitate selective isolation of Acinetobacter.


Input: DESIGN--A randomised double blind placebo controlled parallel arm trial.


Input: Base substitutions within this NFIL-6 site resulted in virtual elimination of LPS-induced IL-1 beta gene transcription.

NFIL-6 site

IL-1 beta gene


Input: Different clinical variants of the empty sella turcica syndrome are demonstrated, including variants resultant from substitution therapy of thyroid hypofunction, from dopamine agonist therapy for hyperprolactinemic hypogonadism, from radiotherapy of hypophyseal adenoma.


Input: Repeated time course studies in the same patient were reproducible although the absolute concentrations showed some variation.


Input: Our data suggest that association of TBP with the TATA box may be regulated, directly or indirectly, by a substrate of Snf1.

TBP


Input: Site-directed mutagenesis of the T4 endonuclease V gene: role of lysine-130.

T4 endonuclease V gene


Input: Simulations of velocities, vorticity, pressure and certain stress values were developed by a computer and displayed for man-machine interaction.


Input: Together, these results implicate Fal1p in the 18S rRNA maturation pathway rather than in translation initiation.

18S rRNA


Input: TRAF2 has previously been demonstrated to activate both transcription factor nuclear factor kappaB (NFkappaB) and the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) pathway, which in turn stimulates transcription factor activating protein 1 (AP1) mainly via phosphorylation of the c-Jun component.

nuclear factor kappaB

NFkappaB

c-Jun N-terminal kinase

stress-activated protein kinase

JNK

SAPK

transcription factor activating protein 1

c-Jun


Input: Electrophysiology and pharmacology of epicardial, endocardial, and M cells.


Input: The data suggest that compromised fibrinolytic capacity may be a contributing factor in the development of thrombosis in patients with the lupus anticoagulant.


Input: Human psychophysical analysis of receptive field-like properties--II.


Input: Furthermore, agonist action at a 5-HT1 receptor and antagonist action at 5-HT2 receptors both appear to contribute to antidepressant-like activity on the DRL 72-s schedule.

5-HT1 receptor

5-HT2 receptors


Input: Heliox improves pulsus paradoxus and peak expiratory flow in nonintubated patients with severe asthma.


Input: Response surface methodology was employed to describe the relationship between soman-induced incapacitation and the ATR/DZ or ATR/SCP dosages.


Input: Both DMP2 and DMP3 are closely localized on mouse chromosome 5q21, corresponding to human chromosome 4q21.


Input: A kinetic model for 99mTc-DMSA in the rat.


Input: Together with the up-regulation of the cAMP response element modulator protein (CREM) mRNA and protein levels demonstrated previously in CREB mutant mice, we suggest that the up-regulation of CREB beta may also contribute to compensation within the CREB/ATF family of transcription factors, when CREB delta and CREB alpha are absent.

cAMP response element modulator protein

CREM

CREB mutant

CREB beta

CREB

ATF

CREB delta

CREB alpha


Input: To examine the effect of the cAMP signal transduction pathway on transcription of the gene encoding the catalytic subunit of glucose-6-phosphatase (G6Pase), G6Pase-chloramphenicol acetyltransferase (CAT) fusion genes were transiently transfected into either the liver-derived HepG2 or kidney-derived LLC-PK cell line.

chloramphenicol acetyltransferase

CAT


Input: The structural intestinal defects are presumed to be the result of defective collagen synthesis in these hereditary connective tissue disorders.

collagen


Input: Letter: Dehydrated test strip for the detection of yeasts.


Input: Galactorrhoea is a rare presentation of an empty sella syndrome.


Input: The transition from expression of early meiotic genes to expression of middle sporulation-specific genes occurs at about the time that cells exit from pachytene and form the meiosis I spindle.


Input: Mutations away from splice site recognition sequences might cis-modulate alternative splicing of goat alpha s1-casein transcripts.

alpha s1-casein transcripts


Input: These Tlr family members, unlike others reported to date, were identified within a genomic database.

Tlr family members


Input: Fig1p and Fig2p are likely to act at the cell surface as Fig1:: beta-gal and Fig2:: beta-gal fusion proteins localize to the periphery of mating cells.

beta-gal

beta-gal fusion proteins


Input: There is little supportive evidence that ACE inhibitors (captopril or enalapril) are teratogenic.

ACE


Input: These results suggest that the PVB therapy is not sufficient to cure the cases with choriocarcinoma element or bulky metastasis.


Input: Evaluation of gamma-glutamyl transpeptidase in myocardial infarction.

gamma-glutamyl transpeptidase


Input: The yjr041c delta haploid cells gave rise to microcolonies comprising about 20 to 50 cells.

yjr041c delta


Input: Mean latency periods were 29. 6 among insulators, 35. 4 among dock workers, 43. 7 in a heterogeneous group defined as various, 46. 4 in non-shipbuilding industry workers, 49. 4 in shipyard workers, 51. 7 among women with a history of domestic exposure to asbestos, and 56. 2 in people employed in maritime trades.


Input: Influence of dietary supplementation with Streptococcus faecium M-74 on broiler body weight, feed conversion, carcass characteristics, and intestinal microbial colonization.


Input: Two plasmids, one containing the amino terminus of P fused to the DNA-binding domain of the yeast transactivator, GAL4, and the other containing the amino terminus of NP fused to the herpesvirus transactivator, VP16, were transfected in COS-1 cells along with a chloramphenicol acetyltransferase (CAT) reporter plasmid containing GAL4 DNA-binding sites.

NP

chloramphenicol acetyltransferase

CAT


Input: 7-Nitroindazole (7NI), a relatively selective neuronal nitric oxide synthase (nNOS) inhibitor. was intraperitoneally administered to the guinea pigs 30 minutes before the onset of local anoxia.

nitric oxide synthase

nNOS


Input: New protein-free products for diet therapy in chronic renal insufficiency


Input: Impact of cytokine gene polymorphisms on outcomes of coronary artery bypass graft surgery.


Input: The human protein binds most strongly to the SH3 domain from the abl proto-oncogene.

SH3 domain

abl proto-oncogene


Input: Adequacy of the Haldane transformation in the computation of exercise V O2 in man.


Input: Covariates were lower extremity range of motion and sensory status.


Input: Like troponin Cs and calmodulins, PfCPK also contains four EF hand calcium-binding motifs.

troponin Cs

calmodulins

PfCPK


Input: Roller pumps, coronary suction and an open cardiotomy reservoir were used.


Input: Akt-dependent antiapoptotic action of insulin is sensitive to farnesyltransferase inhibitor.

Akt

insulin


Input: LT-beta transcription is maximal in the thymic medulla and in splenic white pulp.

LT-beta


Input: Ultrastructure and toxin formation of Cor. diphtheriae PW-8 cultured in the presence of penicillin


Input: Our data indicate that the various subunits of the human P-TEFb complex may play distinct roles at multiple stages to mediate Tat activation of HIV-1 transcription elongation.

P-TEFb

Tat


Input: The organelles synthesize their own set of Fe/S proteins, and they initiate the generation of extramitochondrial Fe/S proteins.

Fe/S proteins

extramitochondrial Fe/S proteins


Input: Ras involvement in signal transduction by the serotonin 5-HT2B receptor.

Ras

serotonin 5-HT2B receptor


Input: Engineering temperature-sensitive SH3 domains.

SH3 domains


Input: Orlistat is a specific lipase inhibitor that impairs fat absorption, thereby reducing fat uptake.

lipase


Input: We identify YY1 recognition sequences within the vitamin D response element (VDRE) of the osteocalcin gene that are critical for YY1-dependent repression of vitamin D-enhanced promoter activity.

osteocalcin gene


Input: The nine subjects were treated in random sequence with cimetidine 0-8-1-0 g on one day and placebo capsules on the other.


Input: ORF3 encodes a putative periplasmic c-type cytochrome with a molecular mass of 94, 000 Da and contains seven c-heme-binding motifs but shows no sequence homology to occ or ORF1.

periplasmic c-type cytochrome

occ


Input: The mutant strain carries three tandem copies of the 18 bp sequence that is duplicated in the amdI66 mutation.


Input: The rat anococcygeus muscle was used in postsynaptic studies.


Input: The HPV E1 and E2 proteins along with cellular factors, are required for replication of the viral genome.


Input: Multiple organ failure (MOF) following major trauma occurs in response to perfusion deficits, a persistent inflammatory focus, or a persistent focus of dead and/or injured tissue.


Input: (i) Several ribosomal proteins were synthesized in substantial excess.


Input: These results suggest that camptothecin resistance in CEM/DOX cells is due to different mechanism (s) than topoisomerase-or P-glycoprotein-associated multidrug resistance.

topoisomerase

P-glycoprotein


Input: The detection limits obtained by using the mixed eluent were 0. 05-0. 13 mg/L, several times lower than those obtained by using single KHPh eluent.


Input: Here we report the fabrication of single-molecule transistors based on individual C60 molecules connected to gold electrodes.


Input: Because of gut fermentation, a substantial portion (16-80%) of N is absorbed as ammonia N (NH3N).


Input: At 1 min postalfentanil, N2O caused significantly more rigidity than 100% O2 (p < 0. 001).


Input: By contrast, CIS failed to affect the IL-9 response.

CIS


Input: Interestingly, PMA-, PDGF-, and serum-induced GHR proteolysis was associated with substantial decreases in GH-induced activation of Janus kinase-2, which were also prevented by IC3.

PDGF

GHR

GH

Janus kinase-2


Input: The centromeric dodeca-satellite of Drosophila forms altered DNA structures in vitro in which its purine-rich strand (G-strand) forms stable fold-back structures, while the complementary C-strand remains unstructured.


Input: The Aspergillus uvsH gene encodes a product homologous to yeast RAD18 and Neurospora UVS-2.

Aspergillus uvsH gene

yeast RAD18

Neurospora UVS-2


Input: These data also suggest the existence of a mechanism by which regulatory subunits modulate the PI 3-kinase-mediated signals, independent of the kinase activity, possibly through subcellular localization of the catalytic subunit or interaction with additional signaling molecules.

PI 3-kinase


Input: A continuous-flow BIPAP system consists of a high-flow CPAP system, a reservoir bag, and a pneumatically controlled membrane valve in the expiratory limb.


Input: This study demonstrates that the exposure to sulphur mustard results in very low androgen levels and hypo-responsiveness to GnRH in the first five weeks and normalization by the twelfth week after injury.

GnRH