Input: The A3B3 domain had a mass of 34, 462, with a glycosylation mass of 14, 900, in good agreement with seven N-linked glycosylation sites of average mass 2100.


Input: In the present study we prospectively compared side effects occurring in 12 patients after the first administration of low-dose OKT3 (0. 5 mg twice daily) induction therapy with those in 10 patients who were treated with a conventional dose of OKT3 (5 mg daily) for acute rejection.


Input: Plasma prolactin concentrations during incubation, 25. 8 +/-2. 3 ng/ml, decreased to baseline levels, 10. 8 +/-1. 9 ng/ml, within 24 hr after nestbox removal.

Plasma prolactin


Input: Our findings suggest that resting Tl-201 scintigraphy has limited value in the detection of coronary artery disease in patients with Hurler syndrome.


Input: Exit from mitosis in Drosophila syncytial embryos requires proteolysis and cyclin degradation, and is associated with localized dephosphorylation.

cyclin


Input: Also, residues 273 to 287, which are identical in sequence to a 15-amino-acid segment near the carboxy terminus of the simian foamy virus transcriptional activator Taf, can independently enhance the activity of the minimal activator region.

simian foamy virus transcriptional activator Taf


Input: The effect of buthionine sulfoximine (BSO) and disulfiram (DSF) on the urotoxicity induced by cyclophosphamide (CPA) was examined in mice.


Input: METHOD: Six instruments were reviewed: the Berg Balance Scale (Berg), the Clinical Test of Sensory Interaction and Balance (CTSIB), the Functional Reach Test, the Tinetti Balance Test of the Performance-Oriented Assessment of Mobility Problems (Tinetti), the Timed " Up and Go " Test (TU & GT), and the Physical Performance Test (PPT).


Input: The side effect of pulmonary fibrosis occurs in 20 to 30 percent of patients receiving this drug.


Input: Of the 47 women with AGCUS, 16 had intraepithelial or invasive neoplasms (34%; 95% confidence interval, 21-49%), including 9 low or high grade squamous intraepithelial lesions, 1 adenocarcinoma in situ of the cervix, 3 adenocarcinomas of the cervix, 2 adenocarcinomas of the endometrium and 1 adenoid basal cell carcinoma of the cervix.


Input: Interestingly, these " activation-defective " mutants segregated into two classes: 1) those that were unable to form dimers but that could still form higher order oligomers and transform cells, and 2) those that were defective for PDGF-R binding and were transformation-incompetent.

PDGF-R


Input: Thus in this study we used in vitro methods to directly evaluate whether isolated human saphenous vein segments respond to vasoconstrictor agents at arterial pressure levels.


Input: Genomic Southern blot analysis suggests that the human haploid genome contains a single Gs alpha gene.

Gs alpha gene


Input: Four cDNAs (Kox4, Kox7, Kox12, and Kox15) were identified that match one or more genomic clones; these matches were confirmed by nucleotide sequence analysis.


Input: The facilitation started preceding the onset of electromyographic activity of the masseter muscle.


Input: Reactivation of hepatitis B virus replication is a rare event during the natural history of chronic hepatitis B.


Input: SETTING--Hospital laboratories in the United States submitting pneumococcal isolates to the CDC between October 1, 1991, and September 30, 1992.


Input: To determine whether transcription of orfX and vfr are controlled by the same mechanisms that control transcription of the region of the divergent ORF (dorf) and of crp, we compared the vfr-orfX and crp-dorf intergenic regions.

vfr

crp

vfr

crp


Input: Cotransfection with C/EBPbeta and GATA-1 expression vectors produced a 5-fold increase compared with cotransfection with the C/EBPbeta or GATA-1 expression vectors individually.

C/EBPbeta

C/EBPbeta


Input: One of these clones encodes Xenopus N-ras.

Xenopus N-ras


Input: Eighteen patients with advanced epidermoid carcinoma of the head and neck were entered into a phase II trial of N-Methylformamide (NMF), 800 mg/M2 IV daily for 5 days every 4 weeks.


Input: Total body water and distribution space of Na24 in women with various body weight


Input: Transient cotransfection analyses indicate that the cooperative association of NF-IL-6 and RelA with the IL-8 promoter results in synergistic transcriptional activation.

RelA

IL-8 promoter


Input: Sera from 33 newborn infants with gestational ages ranging from 27 to 41 weeks were tested by radioimmunoassay for IgG antibodies to surface antigens of group B streptococci (GBS) types Ia, Ib, II and III.

IgG


Input: On average, rCMRglc values were 23% below control values for all regions studied, with the greatest differences in posterior brain regions (visual association cortex, primary visual cortex, and parietal cortex) and thalamus.


Input: The NF1 family members and HNF4 interacted with overlapping sequences of the L-II element, wherein the 5' half-site was more critical for NF1 binding, and the 3' site was more important for HNF4 binding.

NF1 family


Input: The shear bond strength recorded for the Novabond system was significantly lower (17 MPa).


Input: The IR4 ORF exhibits significant homology to the immediate-early gene US1 (ICP22) of herpes simplex virus type 1 and to the ICP22 homologs of varicella-zoster virus (ORF63), pseudorabies virus (RSp40), and equine herpesvirus 4 (ORF4).

immediate-early gene US1


Input: Psoriasis on tumor.


Input: VP4 differentially regulates TRAF2 signaling, disengaging JNK activation while directing NF-kappa B to effect rotavirus-specific cellular responses.

JNK

NF-kappa B


Input: From the autopsy findings, in 5 out of the remaining 23 expired patients, Legionella pneumonia seemed to be successfully treated, but other disease or other bacterial pneumonia put an end to the patients.


Input: We found a prevalence of eating disorders of 5. 9% (lifetime prevalence of 10%), irrespective of gender and type of diabetes; 4. 1% of the whole sample reported intentional insulin undertreatment or omission.

insulin


Input: NER was also measured by a plasmid host cell re-activation assay using a vector containing a luciferase reporter gene.

luciferase reporter gene


Input: Also, like TUB, it has a wider pattern of tissue expression than either TULP1 or TULP2.

TUB


Input: Accuracy and predictive value of ultrasound in acute rejection.


Input: Moist healing versus wet-to-dry.


Input: Flicker thresholds were measured from 1 to 40 Hz with a vertical-line target used for the asynchrony thresholds.


Input: Despite the same decreases or increases in MAP, RSNA was attenuated after 15 and 30 min of propofol infusion in both groups compared with control (P < 0. 05).


Input: Ganglia are cysts which frequently occur in the proximity of joints.


Input: Fractional Ca retention was measured from the 72-h postdose WBR divided by WBR at time 0.


Input: Activity was reconstituted, however, by combining fractions that were enriched in the two components.


Input: Acute morphine treatment did not increase the locomotor activity of mice withdrawn for 1 day, after withdrawal for 3 days the increase was similar to that in controls, and after 5 days the increase was clearly larger than in controls.


Input: A significant and specific reduction in binaural peak amplitude and area of the echo-evoked middle-latency component Pa was observed.


Input: Non-dialyzable transfer factor


Input: Gene 1 of the murine coronavirus, MHV-A59, encodes approximately 800 kDa of protein products within two overlapping open reading frames (ORFs 1a and 1b).

Gene 1 of the murine coronavirus, MHV-A59


Input: Stress thallium-201 myocardial imaging was used in two angina-free patients with severe congestive heart failure to identify clinically silent areas of ischemic myocardium and to distinguish between scar and reversibly ischemic myocardium as a cause for akinesia of left ventricular wall segments.


Input: To understand this dramatic effect, we examined the localization of SR proteins and found that SC35 was shifted to the cytoplasm in sky1Delta yeast, although this phenomenon was not obvious with ASF/SF2, indicating that nuclear import of SR proteins may be differentially regulated by phosphorylation.

SR proteins

ASF

SR proteins


Input: GH stimulated the activity of promoter fragments with 5'-ends between nucleotide (nt)-2001 and nt-653 by 1. 9-to 2. 7-fold.

GH


Input: The 6. 5-kb genomic fragment contains the complete coding region of MyoD, distributed over three exons, plus 2. 3 kb of 5'-noncoding sequence and 1. 4 kb of 3'-noncoding sequence.

MyoD


Input: These observations demonstrate that KSR is capable of uncoupling the MAP kinase activation from its target phosphorylation, and thus provide a novel mechanism for modulating the Ras-MAP kinase signaling pathway.

KSR

MAP kinase

Ras

MAP kinase


Input: Since 1985 the combination of chlorambucil (10 mg daily, initially for six weeks, then alternating fortnights for 12 weeks) and interferon-alpha 2b (Schering-Plough; 2 x 10 (6) U/m2 three times weekly by subcutaneous injection for 18 weeks) has been compared in a randomised trial with chlorambucil alone in previously untreated patients with stage III or IV follicular lymphoma.

interferon-alpha 2b


Input: Correlation of alpha activity between the frontal and occipital cortex.


Input: Nonetheless, the majority were located within three short sequences at the N terminus, middle, and C terminus that are phylogenetically conserved among all known eubacterial and chloroplast versions of this protein.


Input: All other cysts showed a unilocular, purely cystic pattern, with homogeneous fluids, although the T2 relaxation times of four lesions overlapped those of odontogenic keratocysts.


Input: Processing MES data requires large bit manipulations and heavy memory storage requirements.


Input: Recombinant caspases are typically produced in Escherichia coli expression systems with the attendant problems of solubilization, re-folding and activation of the protease.

Recombinant caspases


Input: Nuclear runoff assays show that complementation by HPV16 E7 restores the ability of the E1A mutants to stimulate early gene expression at the level of transcription.

HPV16 E7

E1A mutants

early gene


Input: The effect of deferoxamine B on the blood sugar behavior in intravenous glucose loading in healthy persons


Input: Constructs containing fragments of the upstream region of the cytotactin gene fused to a promoterless gene for chloramphenicol acetyltransferase were transiently transfected into chicken embryo fibroblasts to define functional promoter sequences.

cytotactin gene

chloramphenicol acetyltransferase


Input: Like the human erythrocyte P4. 2, mouse erythrocyte P4. 2 contains regions strikingly homologous with the transglutaminase (TGase) proteins although it too most likely lacks TGase crosslinking activity.

human erythrocyte P4. 2

mouse erythrocyte P4. 2


Input: The rate for Arm III (CAF therapy) was 61. 5% (32/52), a little higher than that for the other two.


Input: The CHL 1 (CTF 1) gene product of Saccharomyces cerevisiae is important for chromosome transmission and normal cell cycle progression in G2/M.

CHL 1

CTF 1


Input: We have analyzed the function of these putative SL structures in RNA translation by constructing chimeric chloramphenicol acetyltransferase (CAT) RNAs, flanked either by both 5'-and 3'-terminal sequence domains from the RV genome or several deletion derivatives of the same sequences.

chimeric chloramphenicol acetyltransferase (CAT) RNAs


Input: Mutating this sequence eliminated complex formation and markedly reduced basal and cAMP-dependent promoter activity of transfected reporter genes.


Input: The average cumulative UVA dose was 65 J/cm2; 40 patients had received more than 200 J/cm2.


Input: The induction of the composite H-PK/Tag and SV-PK/Tag transgenes by a carbohydrate-rich diet in the liver was similar to that of the endogenous L-PK gene.

H-PK

Tag

SV-PK

Tag

endogenous L-PK gene


Input: For routine medical applications, no sophisticated adjustment of the CHESS pulse is needed, as reported in previous methods.


Input: Here we report the cloning of the hemF gene, encoding the aerobic coproporphyrinogen III oxidase from Escherichia coli, by functional complementation of a Saccharomyces cerevisiae HEM13 mutant.

hemF gene

coproporphyrinogen III oxidase from Escherichia coli

Saccharomyces cerevisiae HEM13 mutant


Input: Efficacy of probiotic feed additives: guidelines for the evaluation of the efficiency of microorganisms in dogs, cats, and horses] Probiotic microorganisms are frequently in use as feed additives for farm and pet animals.


Input: We analyzed the contribution of the three different types of UV-inducible mitogen-activated protein (MAP) kinases (ERK, JNK/SAPK, and p38) to the activation of the murine uPA promoter by UV.

mitogen-activated protein (MAP) kinases

ERK

JNK

SAPK

uPA


Input: The largest age adjusted differences between men with low and normal mood were for the AH4 (3 points, t = 5. 6, p < 0. 0001) and the CAMCOG (2 points, t = 5. 8, p < 0. 0001).


Input: Nucleotide sequencing revealed a 2076-base pair open reading frame encoding a 692-amino acid protein.


Input: HrpE is similar to YscL of Yersinia spp.

HrpE

YscL


Input: Mean total homocysteine (tHcy) was 21. 1 +/-9. 5 micromol/L and median concentration was 19 micromol/L.


Input: To facilitate the characterization of NF-E2 functions in human cells, we isolated cDNAs encoding two members of the small Maf family, MafK and MafG.

small Maf family

MafK

MafG


Input: The immediate 5'-flanking region was GC-rich with 3 SP-1-like and 2 AP-2 sites identified in close proximity to the transcription start site.

AP-2 sites


Input: The ZAG1 protein from in vitro translations binds to a consensus target site that is recognized by the AG protein.

ZAG1 protein

AG protein


Input: Bone scintigraphy is an excellent screening test for bone lesions and Ga-67 scintigraphy is a useful tool for detecting inflammatory lesions.


Input: In this first-person account, the author chronicles her experience of being mentally ill and homeless in New York and New Jersey in the early 1980s.


Input: Pharmacokinetics of skin penetration.


Input: Dmyd clone encodes a polypeptide of 332 amino acids with 82% identity to MyoD in the 41 amino acids of the putative helix-loop-helix region and 100% identity in the 13 amino acids of the basic domain proposed to contain the essential recognition code for muscle-specific gene activation.

Dmyd

MyoD


Input: Enterotoxin production by staphylococci isolated from foods in France.


Input: Binding sites were mapped for each factor.


Input: The majority of these cells were also OKT4 positive (helper/inducer T lymphocytes), while the minority were OKT8 positive (suppressor/cytotoxic T lymphocytes).


Input: Toxicological effects of dietary Maillard reaction products in the rat.


Input: All relapses occurred within the first year and were confined to patients with PS II disease and four or more sites of involvement.


Input: These patients developed severe diabetic symptoms including glucose intolerance, weight loss, impaired energy utilization, and nerve and brain disorders that were refractory to insulin.

insulin


Input: Buserelin offers an effective alternative medical treatment of carcinoma of the prostate and, apart from impotence, does not have the side effects of oestrogens.


Input: BCV mRNAs 5 and 5-1 appear to be used for the synthesis of the 12. 7-and 9. 5-kDa proteins, respectively, which demonstrates a pattern of expression strikingly different from that utilized by MHV.

BCV mRNAs 5 and 5-1


Input: Consistent with this observation, introduction of Smad sites into a TGFbeta-insensitive LEF1/TCF target gene confers cooperative TGFbeta and Wnt responsiveness to the promoter.

Smad sites

TGFbeta

TCF

TGFbeta

Wnt


Input: Recombinant vaccinia viruses that express the bacteriophage T3 RNA polymerase (VV-T3pol) or the Escherichia coli lac repressor (VV-lacI) under control of the early-late vaccinia promoter P7. 5 were constructed.

bacteriophage T3 RNA polymerase

Escherichia coli lac repressor

VV-lacI

early-late vaccinia promoter P7. 5


Input: Tritiated 1, 24, 25-trihydroxyvitamin D3 was synthesized biologically and used as tracer to monitor the recovery of endogenous metabolite during isolation from serum.


Input: In this report, we have examined whether PTP1B effects transformation induced by p210 bcr-abl.

p210 bcr

abl


Input: This study examines LEIBNIZ' idea of Veterinary medicine in a biographical context.


Input: Internalization of prolactin receptor and prolactin in transfected cells does not involve nuclear translocation.

prolactin receptor

prolactin


Input: Using the conflict drinking test as a model, we studied in rats the effect of the nonselective beta-adrenoceptor blockers pindolol and cyanopindolol which bind to 5-HT1A and 5-HT1B receptors, and of the selective beta 1-and beta 2-adrenoceptor antagonists betaxolol and ICI 118, 551, respectively, which have a negligible affinity for 5-HT receptors.

beta-adrenoceptor

5-HT1A and 5-HT1B receptors

beta 1-and beta 2-adrenoceptor

5-HT receptors


Input: Rewarding properties of methylphenidate: sensitization by prior exposure to the drug and effects of dopamine D1-and D2-receptor antagonists.

dopamine D1-and D2-receptor


Input: Recently, we have demonstrated that mouse microglial cells, the brain macrophages, express both IL-15 and IL-15/IL-2 receptors.

IL-15/IL-2 receptors


Input: METHODS: Children with attention-deficit/hyperactivity disorder (ADHD; n = 282), all subtypes, ages 6 to 12 years, were randomized to placebo (n = 90), immediate-release methylphenidate (IR MPH) 3 times a day (tid; dosed every 4 hours; n = 97), or OROS MPH once a day (qd; n = 95) in a double-blind, 28-day trial.


Input: Cell sloughing with proparacaine.


Input: The possibility to use this method for common diagnostic problems is indicated.


Input: The deduced amino acid sequence of this open reading frame is significantly homologous to the HSV 1 UL49. 5 gene product, and as with UL49. 5, it contains a potential signal sequence and transmembrane domain characteristic of membrane-associated proteins.

HSV 1 UL49. 5 gene product

UL49. 5


Input: Female Wistar rats receiving alcohol (5%) in drinking water during lactation (N = 7) were compared to normal controls fed ad libitum (N = 6).


Input: Suspected pelvic endometriosis was prospectively evaluated in 31 women with T1-and T2-weighted conventional spin-echo (CSE) magnetic resonance imaging alone and in combination with T1-weighted fat-suppressed (T1FS) and gadolinium-enhanced T1FS (Gd-T1FS) spin-echo techniques.


Input: Eph receptors and their membrane-associated ephrin ligands regulate cell-cell interactions during development.

Eph receptors

ephrin ligands


Input: A group of factors known as activating transcription factors (ATF) have been found to bind to the latter and related sequences found upstream of early adenovirus promoters induced by E1A, and these factors are highly homologous to the CREB protein.

activating transcription factors

ATF

CREB protein


Input: Vk8/Jk2 and Vk1/Jk5 rearrangements encoded the respective L chain V-regions.

L chain V-regions


Input: An analysis of the c-kit 5' flanking region using the bacterial chloramphenicol acetyltransferase gene (CAT assay) in human erythroleukemia HEL cells, which express the endogenous c-kit mRNA at high levels, showed that a region from-180 to-22 is important for the expression of the c-kit gene.

c-kit 5' flanking region

bacterial chloramphenicol acetyltransferase gene

CAT

c-kit mRNA

c-kit gene


Input: The quantitative analysis of 1-alpha-acetylmethadol and its principal metabolites in biological specimens by gas chromatography-chemical ionization-multiple ion monitoring mass spectrometry.


Input: Following immunization of transgenic mice, hybrid molecules were isolated from B cell DNA which contained the transgene recombined with the endogenous IgH locus.

endogenous IgH locus


Input: (LH P < 0. 05, LH/FSH P < 0. 01).

LH

LH

FSH


Input: Here we show that expression of KRAB domain suppresses in vivo the activating function of various defined activating transcription factors, and we demonstrate that the KRAB domain specifically silences the activity of promoters whose initiation is dependent on the presence of a TATA box.

KRAB domain

activating transcription factors

KRAB domain


Input: In the renal cortex, spleen, distal colon, ileum, gallbladder, and stomach body, regional O2 delivery was significantly decreased with hemodilution to 20% in both groups.


Input: None of the 19 women with probable RA and 100 of the 116 women with definite RA met the 1987 criteria.


Input: In response to the need for better quantitative estimates of the regional distribution of the active bone marrow organ in infants and children, a method using various anatomical data has been developed.


Input: Thus the Hi-RARE represents a new type of RA response element with a role in the modulation of the expression of MHC class 1 family genes.

MHC class 1


Input: RESULTS: Considering an inulin clearance of less than 80 ml/min/1. 73 m2, the cut-off value for serum creatinine was 11. 5 mumol/liter for men and 90 mumol/liter for women.


Input: Our results strongly suggest that activation of the beta origin by a distant replication enhancer element requires a small target sequence essential for initiator protein-mediated DNA looping.


Input: Three experiments using 20 microM 2-(hydroxyamino)-1-methyl-6-phenylimidazo [4, 5-b] pyridine (N-OH-PhIP) were performed to induce mutations in the dihydrofolate reductase (DHFR) gene of a hemizygous Chinese hamster ovary (CHO) cell line (UA21).

dihydrofolate reductase

DHFR


Input: The UL3 ORF of 204 amino acids shows significant homology to UL3 (nuclear phosphoprotein) of HSV-1 (62%) and PRV (53%).

UL3 ORF


Input: Immunogenicity tested in experiments on guinea pigs and rabbits was not reduced and corresponded to that of the reference STI-1 vaccine.


Input: In addition, we show that expression of antisense mRNA for p130CAS resulted in reversion of the transformed phenotype of all these cell lines.


Input: One hundred cDNA clones were sequenced and 8 RTKs were identified, as well as 12 non-RTKs and 2 serine/threonine kinases.

RTKs

RTKs

serine/threonine kinases


Input: Supportive therapy with xenogenous peptides in patients with metastatic breast cancer undergoing aggressive chemotherapy (modified AC-protocol): a prospective, randomized double-blind study


Input: The inactive X allele, however, is hypermethylated in leukocytes, presumably reflecting early X inactivation events that become important for gene dosage in expressing lineages.


Input: Development of neural control of alimentary motor function in the vertebrates.


Input: Studies on nitrogen-containing heterocyclic compounds.


Input: Cell rounding was abrogated by expression of either kinase-dead forms of US3 PK or a mutant protein lacking the acidic cluster in the kinase regulatory domain.

US3 PK


Input: The psychosocial features of people using self-ignition as a method of suicide are consistent with those of suicide in general.


Input: The genes expressed during the embryonic (zeta) or fetal and adult stage (alpha 2 and alpha 1) can be modified by point mutations which affect either the processing-translation of mRNA or make the polypeptide chains extremely unstable.

zeta

alpha 2

alpha 1


Input: Acoustic-property measurements of the oxide superconductor BaPb1-xBixO3 by the sphere-resonance method.


Input: The fusion of AML1 to MDS1 is in frame, and adds 127 codons to the interrupted AML1.


Input: The ends of the barrel are capped by short helices.


Input: Rabbit KCC1 (rbKCC1) and rat KCC1 (rtKCC1) were cloned by screening rabbit kidney and rat brain cDNA libraries using homologous cDNA probes.

Rabbit KCC1

rat KCC1


Input: Taken together, these findings demonstrate that ZNF76 and ZNF143 are two members of a same family of transactivator proteins.


Input: This model system exploits the polyomavirus late transcription termination and polyadenylation signals, which are sufficiently weak to allow the production of many multigenome-length primary transcripts with repeating introns, exons, and poly (A) sites.


Input: The disorders are accompanied by consistent, but similarly reversible, electroencephalographic changes.


Input: Electronic structure and optical properties of the B12O2 crystal.


Input: A model for oligomerization-dependent subunit folding.


Input: The reporter gene with two copies of the wild-type Repeat 2 + 3 sequence was transcribed actively in sterol-deprived cells and was repressed by more than 80% when sterols were present.


Input: Basic helix-loop-helix proteins can act at the E-box within the serum response element of the c-fos promoter to influence hormone-induced promoter activation in Sertoli cells.

Basic helix-loop-helix proteins

c-fos promoter


Input: Preventive health counseling tailored to the needs of this group may be most beneficial.


Input: Western blot analyses reveals that cJun and the C/EBP family member C/EBP-beta are physiologically relevant transcription factors whose expression corresponds with mda-7 mRNA expression.

cJun

C/EBP family member C/EBP-beta

mda-7 mRNA


Input: Recent developments in the study of growth factors: GRF and somatomedins.

GRF

somatomedins


Input: Phenotypic screening of mutations in Pmr1, the yeast secretory pathway Ca2 +/Mn2 +-ATPase, reveals residues critical for ion selectivity and transport.

yeast secretory pathway Ca2 +/Mn2 +-ATPase


Input: IV.


Input: Routine and default retrieval home visits were given to ensure maximal drug compliance.


Input: This review chronicles the characteristics of deliberate and accidental mass poisonings that occurred in World Wars I and II, in Bhopal, and in other historical cases up to and including modern wars.


Input: Thus, an unmodified threonine at position 169 in Cdc28 is important for interaction with G1 cyclins.

G1 cyclins


Input: These alterations occurred at both the mRNA and protein levels but did not significantly affect the subcellular distribution of any of the four isoforms.


Input: Periarteritis nodosa with ruptures of the renal vessels and the persistence of the hepatitis B and C viruses in the blood


Input: SETTING: Participants in the Physicians' Health Study, a randomized trial of aspirin and beta-carotene among U. S. male physicians.


Input: Treatment of chronic hepatitis B with interferon: experience in western countries.

interferon


Input: Similar to what was observed for P. putida, a psrA null mutant of P. aeruginosa also showed a 90% reduction in rpoS promoter activity; both mutants could be complemented for rpoS promoter activity when the psrA gene was provided in trans. psrA mutants of both Pseudomonas species lost the ability to induce rpoS expression at stationary phase, but they retained the ability to produce quorum-sensing autoinducer molecules.

psrA

rpoS promoter

rpoS promoter

psrA gene

psrA mutants

rpoS


Input: The increments in median plasma secretin concentration were 1. 6, 3. 0, and 6. 4 pmol x 1 (-1) after secretin, 125, 250 and 500 fmol x kg-1, and the corresponding 15-min bicarbonate output 283, 442, and 1435 micromol, respectively.

plasma secretin

secretin


Input: The composition of renal stones analysed by infrared spectroscopy.


Input: Programmed peritoneal lavage in suppurative complications of perforated ulcer of the stomach


Input: Vibrio cholerae iron transport: haem transport genes are linked to one of two sets of tonB, exbB, exbD genes.

tonB

exbB

exbD genes


Input: Zonography in urology (author' s transl)


Input: Phenazopyridine-induced hemolytic anemia in a patient with G6PD deficiency.


Input: The novel gene spans 16. 7 kb of genomic sequence and it is formed of 11 exons and 10 intervening introns.


Input: Overexpression of a HIF-1alpha construct with deletions of the basic domain and carboxy terminus blocked reporter gene activation by endogenous HIF-1 in hypoxic cells.


Input: A preformed SREBP-1a: [32P] DNA complex bound specifically to membrane-immobilized GST-CBP fusion proteins that contained amino-terminal portions of CBP.

SREBP-1a: [32P] DNA complex

GST

CBP

CBP


Input: Extracellular protein kinase A as a cancer biomarker: its expression by tumor cells and reversal by a myristate-lacking Calpha and RIIbeta subunit overexpression.

Extracellular protein kinase A


Input: By incorporating a stent with posts that pivot about their base, such that a 10% expansion at the commissures is realized, we were able to reduce the compressive commissural stressing from 250 to 150 kPa.


Input: With rats fed on the Zn-sufficient diet, NaFe3 + EDTA and Na2EDTA similarly increased the absorption, urinary excretion and retention of Zn but to a lesser extent.


Input: The requirement for an essential interaction between NPH I and H4L provides an explanation for the observed restriction of transcription termination to early viral genes.

NPH I


Input: Other clinicopathological features have no definite influence in survival expectancy.


Input: Births, marriages, divorces, and deaths for July 1997.


Input: One day postoperatively, the mononuclear leukocyte beta 2-receptor density decreased maximally by 45 +/-11% in the enflurane patients, and by 53 +/-6% in the neurolept patients.

beta 2-receptor


Input: A direct statistically reliable correction of decrease of the enzymes with the initial state of the patients has been established in an analysis of 25 patients aged from 18 to 60 years in prosthesis of + the mitral valve (n-9) and closed mitral commissurotomy (n-16).


Input: However, it was observed that storage time affected significantly the biochemical changes occurring in the constituents of carrots exposed to gamma-irradiation.


Input: Partial proteolysis of cell surface-iodinated B-G molecules generates extremely similar patterns of spots, both within and between haplotypes.

B-G molecules


Input: Here we demonstrate the ability of oligonucleotides containing the C4T sequence to confer heat shock inducibility on the reporter gene and show that the presence of two such elements produces more than additive effects on induction.


Input: In the other two groups (NAAR and PLA), no variation in this serum protease was observed.


Input: The KEMAR measurements show that the two models give an improvement of the signal-to-noise ratio of approximately 7. 5 dB in a diffuse sound field.


Input: Providing appropriate care to both sexes.


Input: An X-linked zinc finger gene mapping to Xq21. 1-q21. 3 closely related to ZFX and ZFY: possible origins from a common ancestral gene.

zinc finger gene

ZFX

ZFY


Input: Mutations that extend the specificity of the endonuclease activity of lambda terminase.

lambda terminase


Input: Promoter activity was assayed by transient transfection of luciferase reporter constructs containing nested deletions of the upstream sequence in the human RPE cell lines ARPE19 and D407, as well as in the SK-Mel-28 and HeLa cell lines.

luciferase reporter constructs


Input: These results suggest an essential role of the binding of HNF-4 and/or HNF-4-related nuclear factors to the 6 beta A-A site on the basal transcriptional activation of the CYP3A2 gene in liver cells.

HNF-4-related nuclear factors

CYP3A2 gene


Input: A vascular component to impotence was shown to be common in those with neurological impairment, and may alter management.


Input: Bandwidth of auditory units in the chick forebrain (field L/Hv complex) was measured with isointensity tone stimuli.


Input: Two cases of Paraquat poisoning of anticonservative origin are described.


Input: The promoter of this methyltransferase gene lacks an identifiable TATA box but is characterized by a CpG island which begins approximately 723 nucleotides upstream of the major transcriptional start site and extends through exon 1 and into the first intron.


Input: It also describes the preliminary results of a Phase II trial going on at the Central Institute for Tumors in Zagreb, using a combination of cis-DDP, 5-fluorouracil and vincristine.


Input: Three patients with Mirizzi type II syndrome and two patients with Mirizzi type I syndrome were treated laparoscopically.


Input: The pregnancies were terminated at 19 and 12 weeks of gestation, respectively.


Input: The treatment with glucocorticoids and immunosuppressants resulted in a more noticeable decrease in the levels of T3 and E-RCF.

E-RCF


Input: It is concluded that the new class of competitive NMDA receptor antagonists, exemplified by CGP 37849, is the most promising candidate for clinical trials in anxiety disorders.

NMDA receptor


Input: Rapid, sensitive gas chromatographic analysis of 8-methoxypsoralen in human plasma.


Input: RESULTS: Sixty-one percent of the patients had damage within 7 years of onset (mean 3. 8 yrs).


Input: In the fungus Neurospora crassa, nit-2, the major nitrogen regulatory gene, activates the expression of unlinked structural genes that specify nitrogen-catabolic enzymes during conditions of nitrogen limitation.


Input: We concluded that HFV can achieve values of CO2 elimination close to the estimated metabolic CO2 production in normal unintubated subjects over short periods of time.


Input: Tetrazepam: a benzodiazepine which dissociates sedation from other benzodiazepine activities.


Input: Transcripts appear to be initiated from an upstream promoter, P1, located in front of the tRNA (met1) gene and from three internal promoters: P2 is located immediately in front of the tRNA (met2) gene; PL10 is near the beginning of the L1-L10 intergenic space, and PL12 is at the end of the L10 gene sequence.

tRNA (met1) gene

tRNA (met2) gene

L10 gene sequence


Input: Nearly 1. 5 million American men age 65 and older have osteoporosis, and another 3. 5 million are at risk.


Input: We have characterized 21 mutations in the type VII collagen gene (COL7A1) encoding the anchoring fibrils, 18 of which were not previously reported, in patients from 15 unrelated families with recessive dystrophic epidermolysis bullosa (RDEB).

type VII collagen gene


Input: A case of heterotopic gastric mucosa (pyloric gland) in the wall of the gallbladder was reported.


Input: Ribosome association of GCN2 protein kinase, a translational activator of the GCN4 gene of Saccharomyces cerevisiae.

GCN2 protein kinase

GCN4 gene


Input: We further examined the interaction of JAK2 with the GHR cytoplasmic domain by two lines of investigation.

GHR


Input: These segments may represent pseudogenes.


Input: Corresponding oligonucleotides were used to screen a rat liver cDNA library constructed in the plasmid cloning vector, pcDV.


Input: A.


Input: Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR.

Extracellular regulated kinases (ERK) 1

dual-specificity protein-tyrosine phosphatase VHR


Input: The model therefore predicts that 1) on-line calculation of airway dead space and end-expired lung volume can be made by the addition of an oxygen sine-wave perturbation component to the mean FIO2; and (2) QS/QT can be measured from the resultant oxygen perturbation sine-wave amplitudes in the expired gas and in arterial and mixed-venous blood and is independent of the mean blood oxygen partial pressure and oxyhemoglobin saturation values.

oxyhemoglobin


Input: An anoerxiant, mazindol suppresses food intake by 1) stimulating beta-adrenergic receptors, 2) inhibiting the feeding center and, 3) stimulating the satiety center in the hypothalamus.

beta-adrenergic receptors


Input: When patients were admitted within one week of the onset of dark urine, 45% were found to be shedding HAV, whereas only 11% of specimens obtained from patients admitted during the second week contained virus.


Input: Positive effects of radioactive therapy in Guarapari


Input: Nevertheless, lower doses which alone were lacking in activity (100-250 mg/kg B1 and B6, 1-2. 5 mg/kg B12 p. o.) dose-dependently potentiated the antinociceptive of diclofenac.


Input: Escherichia coli strains carrying recA730 (or other recA * alleles) exhibit dramatic increases in SOS-dependent spontaneous mutator activity.

recA * alleles


Input: On the contrary i. v. administration of calcitonin increased intrapyloric pressure via vagal nerves in atropinized or gallaminized animals.

calcitonin


Input: An hcr1 null mutant was viable, but showed slight reduction of growth when compared with the wild-type strain.


Input: Overall, free-chlorine treatments (0. 3 or 1. 0 mg/L) showed significantly lower heterotrophic plate numbers than those without free chlorine.


Input: This evaluation examines several analytical and cost parameters for five representative assays: IgG, IgA, IgM, phenytoin, and phenobarbital.

IgG

IgA

IgM


Input: We have previously identified LIT1, a paternally expressed antisense RNA within the KvLQT1 locus through a positional screening approach using human monochromosomal hybrids.

KvLQT1 locus


Input: Here RFX/X2BP/DNA complexes were formed on all class II isotypes regardless of the ability of the X box region to bind either factor individually.

RFX


Input: Developmental slot blots demonstrate that mRNAs corresponding to the three LHM cDNAs are transcribed from prophase of meiosis I to the uninucleate microspore stage, while Northern analysis reveals these tapetally expressed cDNAs to correspond with transcripts of some 500 bp.

LHM cDNAs


Input: The curse of the Pharaohs.


Input: The women in the intermediate calcium group had approximately the same mean BMD values as those in the low calcium group.


Input: The enigma of aging bone loss.


Input: RESULTS: After lavage, a rapid decrease in arterial pH and PaO2, and an increase in PaCO2 and PIP were observed in all animals.


Input: In both cell types, insulin led to a dose-dependent increase in the association of tyrosine phosphorylated IRS-1 with the SH2 domain of the p85 regulatory subunit of PI-3 kinase, and also increased the amount of PI kinase activity detected in anti-IRS-1 immunoprecipitates.

insulin

tyrosine phosphorylated IRS-1

SH2 domain

p85 regulatory subunit

PI-3 kinase

PI kinase


Input: Twelve (92%) showed cognitive dysfunction including impairments in memory, attention, and affective disturbances (anxiety, depression, irritability, and poor frustration tolerance).


Input: These effects were antagonized by prior administration of 1-(2-methoxyphenyl)-4-[-(2-phthalimido) butyl] piperazine) (0. 5 mg/kg, i. p.).


Input: Transcription initiation from this region was also detected in vivo, when the cloned rRNA gene cluster was present on a multi-copy plasmid.


Input: The human parvalbumin mRNA contains the putative polyadenylation signal AATAAA 13 nucleotides upstream from the polyadenylation site.

human parvalbumin mRNA


Input: The effects of dopamine and of dopamine D2 receptor blocker haloperidol on the activity of carotid chemoreceptors were studied in 24 anesthetized, paralyzed and artificially ventilated newborn kittens aged 0-17 days.

dopamine D2 receptor


Input: DNMT2 binds AdoHcy in the same conformation as confirmed m (5) C MTases and, while DNMT2 shares all sequence and structural features with m (5) C MTases, it has failed to demonstrate detectable transmethylase activity.

m (5) C MTases

m (5) C MTases


Input: Serum amyloid A (SAA) is a plasma protein which has been associated with several diseases, including amyloidosis, arthritis, and atherosclerosis, and its abnormal expression, particularly in nonhepatic cells, is implicated in the pathogenesis of these diseases.

Serum amyloid A

SAA


Input: The standardized incidence in Europeans has risen significantly to 4. 7/10 (5)/year from 3. 4/10 (5)/year in the 1970s (chi 2 = 8. 1, p less than 0. 005).


Input: Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes.

human MHC

HKE4 genes


Input: The cells arrest in the G1 phase of the cell cycle and grow a projection towards one another forming a shmoo projection.


Input: Multiple aortic thrombi associated with protein C and S deficiency.

protein C

S


Input: However, the optimum compressive strength reached values up to 40% higher than CC-free samples.


Input: POPULATION AND METHODS: 105 patients were followed prospectively (male: 87%; age: 56 +/-10); clinical evaluation was performed in the 1st, 3rd and 6th month, SEKG in the 4th month and recatheterization for angiographic control in the 6th month.


Input: The practice of measuring of AChE levels in acute poisoning is limited.

AChE


Input: M., Adrich, Z., Fournet, B., Capon, C., Bonicel, J.


Input: Confocal fluorescent microscopy analysis demonstrated that WT, VaI, and VaII all distribute equally to the cell surface while, as expected, a WT mutant lacking the two C-terminal valine residues does not.


Input: The amount of ERCC1 detectable by immunoblotting is reduced in group 1, group 4 and XP-F extracts.


Input: Letter: Ballistocardiography.


Input: Metabolic studies of tetrabenazine, a psychotropic drug in animals and man.


Input: From the frozen specimen, a large number of sections with good morphologic characteristics may be produced.


Input: Gene transcripts are detected on tissues such as bovine liver, kidney, lung, and brain.


Input: Plasma enteroglucagon was measured before and during three hours after a standard meal in 21 untreated adult patients with suspected coeliac disease who all had villous atrophy of the small intestinal mucosa and malabsorption, and in nine control subjects.

Plasma enteroglucagon


Input: In this report, we establish that the heteromeric CCAAT-binding factor CBF is the major component of the C1-binding factor (C1F) in human cells.

CCAAT-binding factor CBF

C1-binding factor


Input: This growth-inhibitory effect was suppressed by the mpk1 delta mutation, suggesting that hyperactivation of the Mpk1 pathway is toxic to cells.

mpk1 delta


Input: The human PAX8 gene generates at least five different alternatively spliced transcripts encoding different PAX8 isoforms.

human PAX8 gene

PAX8 isoforms


Input: The use of specific somatic cell hybrids have allowed us to locate the YAC contig telomeric to the D3F15S2 locus, in a region which is frequently deleted in lung carcinomas.

D3F15S2 locus


Input: A close homologue of the APK2a gene, named APK2b, was also isolated from the Arabidopsis cDNA library.

APK2a gene


Input: Characterization of Chlamydomonas reinhardtii zygote-specific cDNAs that encode novel proteins containing ankyrin repeats and WW domains.

ankyrin


Input: Subsequent analysis revealed that MyD88 possesses a unique modular structure, which consists of an N-terminal " death domain, " similar to the intracellular segments of TNF receptor 1 and Fas, and a C-terminal region related to the cytoplasmic domains of the Drosophila morphogen Toll and vertebrate interleukin-1 receptors.

TNF receptor 1

Fas

Drosophila morphogen Toll

interleukin-1 receptors


Input: A. nidulans transformants secreted high amounts of PGI and PGII in comparison to the previously characterized A. niger transformants and a novel polygalacturonase (PGC) was produced at high levels by A. nidulans transformed with the subcloned pgaC gene.

PGI

PGII

polygalacturonase

PGC

pgaC gene


Input: Role of zinc-finger proteins Sp1 and zif268/egr-1 in transcriptional regulation of the human synaptobrevin II gene.

zinc-finger proteins Sp1

human synaptobrevin II gene


Input: However, the recovery curve of the R2 component of the blink reflex diminished in patients with tension-type headache compared with the other groups.


Input: The GvpE protein involved in the regulation of gas vesicles synthesis in halophilic archaea has been identified as the transcriptional activator for the promoter located upstream of the gvpA gene encoding the major gas vesicle structural protein GvpA.

GvpE protein

gvpA gene

GvpA


Input: TFIIIB assembles autonomously on the upstream promoter of the yeast U6 snRNA (SNR6) gene in vitro, through the interaction of its TBP subunit with a consensus TATA box located at base pair-30.

TFIIIB

yeast U6 snRNA

TBP subunit


Input: Effect of bromocriptine and metoclopramide on serum prolactin levels in patients with amyotrophic lateral sclerosis.

serum prolactin


Input: Experience in using the Romashka-1 laser surgical unit in treating suppurative wounds


Input: At a cutoff point for KISA% of 100, 280 of 281 participants (99. 6%) were correctly classified.


Input: To evaluate the effect of selective thromboxane A2 blockade on clinical findings and platelet reactivity in refractory unstable angina, OKY-046 (600 mg/day, p. o.) was administered to another 14 patients with refractory unstable angina in addition to the conventional therapy.


Input: The AP-1 recruited by ARF1. GTP is released from the Golgi membrane by treatment with 1 M Tris-HCl (pH 7) or upon reincubation at 37 degreesC, whereas AP-1 recruited with GTPgammaS or by a constitutively active point mutant, ARF1 (Q71L), remains membrane bound after either treatment.

ARF1. GTP

ARF1 (Q71L)


Input: In K562 cells, using the bicistronic vector, selection with colchicine led to at least 20-fold higher expression of the MDR1 gene product than did selection with G418, suggesting that the stringent MDR1 selection system is very efficient for obtaining overexpression of foreign genes.

MDR1 gene product


Input: A surge in the rate of ascorbyl radical production, directly correlated with oxyradical stress and an abrupt fall in superoxide dismutase activity in the granuloma, indicates' switching on' of a free radical-dependent machinery for the formation of granuloma after vasectomy.

superoxide dismutase


Input: The vaccine was highly immunogenic, since 111 of 113 patients (98%) produced anti-HBs (10 mIU/ml or more).

anti-HBs


Input: Papillomavirus type 16 oncogenes downregulate expression of interferon-responsive genes and upregulate proliferation-associated and NF-kappaB-responsive genes in cervical keratinocytes.

interferon

NF-kappaB


Input: A model for the SMase-sphingomyelin complex structure was built to investigate how the SMase specifically recognizes its substrate.

SMase

SMase


Input: MADS-box genes in plants are a diverse class of transcription factors that are involved in regulating developmental processes, particularly meristem and organ identity during floral development.

MADS-box genes


Input: RESULTS: In the test data set, the single-sample model was confirmed to give excellent estimation of the AUC: AUC (mg/ml x min) = 0. 93 x C3h + 0. 47 (MPE% = 4. 4%, RMSE% = 8. 9%).


Input: Our results show that a combination of Pfu exo (-) at the primer extension step and Taq at the PCR amplification step is ideal for in vivo DNA analysis and DNA damage mapping using LMPCR.

Pfu exo (-)

Taq


Input: KU-1257 also significantly accelerated the healing of acetic acid-induced duodenal ulcers as well as famotidine and roxatidine acetate.


Input: Prolongation of prothrombin time was not due to depletion of vitamin K-dependent coagulation factors or manifest fibrinolysis, but due to the presence of circulating fibrinogen fibrinmonomer-FDP complexes.

prothrombin

fibrinogen fibrinmonomer


Input: Clostridium botulinum in marine sediment


Input: Upstream stimulatory factor USF is a human transcriptional activation factor, which uses a basic/helix-loop-helix/leucin zipper (b/HLH/Z) motif to homodimerize and recognize specific sequences in the promoter region of both nuclear and viral genes transcribed by RNA polymerase II.

Upstream stimulatory factor USF

RNA polymerase II


Input: Fusion of mouse CD8 + class I MHC-restricted T cells with the BW5147 thymoma invariably yields CD8-hybridomas in which RNA transcribed from the CD8 alpha (Lyt-2) gene is undetectable.

mouse CD8 + class I MHC

CD8 alpha


Input: Consistent with this hypothesis, alpha1-PDX prevents cleavage of BMP-4 in an oocyte translation assay.


Input: Convergence of trigeminal input with visceral and phrenic inputs on primate C1-C2 spinothalamic tract neurons.


Input: In this study we cloned the cDNA of AD1 Ag from a rat basophilic leukemia 2H3 cDNA library.

AD1 Ag


Input: Several sequences resembling binding sites for liver-and fat body-specific transcription factors were identified within 1 kb upstream and downstream of the gene.


Input: Root surface caries incidence in the groups inoculated with A. viscosus and A. viscosus plus S. sobrinus did not differ.


Input: METHODS AND RESULTS: The QTd and JTd intervals in 39 children with long QT syndrome were compared to those of 50 normal age-matched children.


Input: The prgX gene is adjacent to prgQ which provides the promoter for prgB expression.

prgX gene

prgQ

prgB


Input: A Frank vectorcardiogram was recorded before and every 15-30 minutes for 10 hours after the occlusion.


Input: The treatment of Sudeck' s atrophy in the upper limb by sympathetic blockade.


Input: Frequency of recurrence of fibroids after myomectomy has been evaluated in 145 women (median age 38 years, range 21-52) who underwent myomectomy.


Input: There is a good correlation between the occurrence in any particular vascular segment of the transient contractile response and intrinsic tone as assessed by relaxation to papaverine (10 (-6) M).


Input: The antimicrobial of choice for initial prophylactic therapy among asymptomatic pregnant women exposed to Bacillus anthracis is ciprofloxacin, 500 mg twice a day for 60 days.


Input: Spontaneous coronary artery spasm during coronary angiography in a patient with exercise-induced ST segment elevation.


Input: Nickel release from tools on the Swedish market.


Input: There was no correlation between starting platelet-associated IgG levels or changes in platelet-associated IgG levels with therapy and the increment in the patient' s platelet count.

IgG

IgG


Input: The receptor for CSF-1, c-Fms, is expressed in osteoclasts, possesses intrinsic tyrosine-kinase activity, and signals via rapid phosphorylation of selected proteins.

c-Fms

tyrosine-kinase


Input: In a rat model of SAH, we assessed BBB changes by means of the quantitative [14C]-alpha-aminoisobutyric acid technique.


Input: BAG-1 also prevented growth arrest following UV-irradiation-induced genotoxic injury without interfering with accumulation of p53 protein or p21 (waf-1) expression.

p53 protein


Input: During the last three days of the study, mean urine osmolality (Uosm) and free water reabsorption (TCH2O) increased significantly: [formula: see text].


Input: [(OP) 2Cu] + also detected protections in the C alpha-helix, the interdomain hinge, and beta-strands 2-7.


Input: When O-2A/c-myc cells underwent terminal differentiation APprog complexes were lost and conventional AP-1 DNA-binding activity became evident, particularly in astrocytes.

c-myc

APprog complexes


Input: The gene, from the initiator methionine to the polyadenylation site, is contained within 13 244 basepairs and contains 19 exons.


Input: To study structural diversity of the three homologous loci encoding a KN1-like homeobox protein in the hexaploid wheat genome, we isolated clones from a cDNA library of young spikes of Japanese common wheat cultivar' Norin 26'.

KN1-like homeobox protein


Input: Treatment is based on antifungal drugs, most frequently nystatin, amphotericin B and ketoconazole.


Input: Controversy exists regarding both the natural life cycle for this parasite as well as the species identity of opossum Sarcocystis.


Input: Here we report that components of the Ras/Raf/MAPK pathway are constitutively activated in these lck-transformed immature thymoblasts. p56 (lck) utilizes Shc and Grb2 adaptors to mediate activation of p21 (ras) in the thymoblast lines by promoting tyrosine phosphorylation of the Shc protein and constitutive interaction between Shc and Grb2.

Ras

Raf

MAPK

lck

lck

Shc

Grb2 adaptors

ras

Shc protein

Shc


Input: Unfractionated heparin (UFH) given at a dose of 0. 3 mg x kg-1 bolus + 0. 3 mg x kg-1 x h-1 infusion did not improve the incidence of reperfusion or lower the incidence of reocclusion.


Input: The quantification limit was 50 ng/ml for each of PHT, m-HPPH and p-HPPH.


Input: Plasma hemopexin homeostasis during the acute phase response.

Plasma hemopexin


Input: Our aim was to check whether, during PG-DS administration, serum lipase activity changes simultaneously with serum amylase activity, and, if so, what the reason is for the detected change.

lipase

amylase


Input: (i) The chimeric gene consisting of the coding and 5' nontranslated leader regions of the TK gene fused to portions of the domain of alpha gene 0 extending largely upstream from the site of initiation of transcription of alpha gene 0 was regulated in the same fashion as the alpha 4-and alpha 27-TK chimeras.

TK gene

alpha gene 0

alpha gene 0

alpha 4-and alpha 27-TK


Input: Cytokines and steroid hormones use different sets of signal transduction pathways, which seem to be unrelated.


Input: This is the most northern and, at the same time largest, Q fever epidemic recorded in Germany over the last 28 years.


Input: Genetic analysis of the role of herpes simplex virus type 1 glycoprotein K in infectious virus production and egress.

herpes simplex virus type 1 glycoprotein K


Input: The 5' half of the EWS gene has recently been described to be fused to the 3' regions of genes encoding the DNA-binding domain of several transcriptional regulators, including ATF1, FLI-1, and ERG, in several human tumors.

EWS gene

ERG


Input: We used high-resolution ultrasound to characterize postprandial antral excursion characteristics in 15 healthy volunteers.


Input: Multivariable logistic regression showed that mean blood glucose level for the first 2 days (p = 0. 002), obesity (p < 0. 002), and use of the internal mammary artery (p < 0. 02) were all independent predictors of deep wound infection.


Input: Fine tangled pili expressed by Haemophilus ducreyi are a novel class of pili.


Input: CONCLUSIONS: The RRM is one of the most common and best characterized RNA-binding motifs.


Input: Torsion of the contralateral testis 5 years after orchiopexy.


Input: Serum levels of total and specific immunoglobulin E (IgE) have been determined by radioimmunoassays in sixty-nine allergic subjects.

specific immunoglobulin E

IgE


Input: The largest one probably corresponds to the precursor form of PS2 in E. coli.


Input: Transcriptional analysis indicates that human TBP functions poorly at promoters recognized by RNA polymerases I and III and at RNA Pol II promoters lacking a conventional TATA element.

human TBP

RNA polymerases I and III

RNA Pol II promoters


Input: Elements of the hAT transposon family, such as the maize activator (Ac), have been discovered in a large number of eukaryotic species.

hAT transposon family

maize activator

Ac


Input: The identification of SRP54sc and SRP54sp provides the first evidence for SRP related proteins in yeast.

SRP


Input: We have isolated two H19 cDNAs (AP and ES) that contain this ORF4 and correspond to incomplete copies of the unique 2. 3 kb H19 RNA.

H19 cDNAs

AP

ES

2. 3 kb H19 RNA


Input: Urease activity, judged as the amount of ammonia production from urea, could be measured at 25 ng per tube (S/N = 1. 5) with Jack bean meal urease.

Urease

Jack bean meal urease


Input: Radioimmunoassay of plasma gonadotropins; problems of specificity

plasma gonadotropins


Input: Tissue expansion was used successfully to prepare adequate soft tissue for closure following a difficult clubfoot correction.


Input: Legionella antibodies in domestic animals

Legionella antibodies


Input: In a previous study of transforming growth factor-beta1-mediated inhibition of the cyclin A promoter, we mapped the inhibitory effect to the ATF site; in the present study of IFN-gamma treatment, functional analysis by transient transfection showed that inhibition of the cyclin A promoter persisted despite mutation of the ATF, NF-Y, or CDE elements.

transforming growth factor-beta1

cyclin A promoter

ATF site

IFN-gamma

cyclin A promoter

ATF

NF-Y


Input: No significant difference was seen found between the two groups in the degree of postoperative deterioration in cardiopulmonary function or in interleukin-6 levels.


Input: We show that GCNF binds to one of the two DRO sequences in the Prm1 promoter, and to the DRO sequence in the Prm2 promoter in a specific manner.

GCNF

Prm1 promoter

Prm2 promoter


Input: The strategy uses RNA ligase to add DNA oligonucleotide priming sites to the RNA for subsequent reverse transcription and PCR (RNA ligase, reverse transcription-PCR, or RL/RT/PCR).

RNA ligase

RNA ligase


Input: From 1977 to 1985, 42 patients with squamous cell carcinoma of the anal canal were treated with mitomycin C (15 mg/m2) and 5-fluorouracil (750 mg/m2) on day 1, 5-FU (750 mg/m2/d) alone on days 2 to 5, and radiation therapy (3000 cGy) on days 7 to 28.


Input: Effect of choline magnesium trisalicylate on prostacyclin production by isolated vascular tissue of the rat.


Input: The magnitude of all four parameters increased in an exponential fashion with increasing sperm number up to 400 x 10 (6) per ejaculate.


Input: A sharp transition from a random chaotic state to a correlated turbulent state of finite coherence time is found when the Rayleigh number becomes larger than a critical value Ra (c) approximately equal to 5 x 10 (7).


Input: In HMEC stably transfected with an ER mutant containing a deletion in the second zinc finger of the DNA-binding domain, E and HT had different effects on EBBP gene expression; EBBP regulation by E was dramatically reduced while the effects of HT were augmented.

ER mutant

EBBP gene

EBBP


Input: 6 h after ingestion of aspirin on day 1 to day 14, both TX and PGI2 levels also significantly decreased (p < 0. 0001).


Input: When transfected into HepG2 cells, which lack C/EBP alpha, the mouse ob promoter was only weakly active.

C/EBP alpha

mouse ob promoter


Input: Desarrollo de un modelo matematico general para los procesos fermentativos, Cinetica de la degradacion anaerobia, Ph. D.


Input: NF-kappaB DNA-protein binding and ICAM-1 promoter activity were enhanced by IL-1beta and these effects were inhibited by tyrphostin 23, but not by PD 98059 or SB 203580.

NF-kappaB

ICAM-1 promoter


Input: In murine cells, FPGS expression is controlled by two promoters that, as we show here, vary substantially in their efficiency, at least in the context of a reporter gene assay.

FPGS


Input: Quantitative measurement of antigamma globulin factors (rheumatoid factors) using laser-nephelometry in comparison with the latex agglutination test and the Waaler-Rose test

antigamma globulin factors

rheumatoid factors


Input: Disruption of INP53, but not the related INP51 and INP52 genes, resulted in alpha-factor maturation defects and exacerbated alpha-factor maturation defects when combined with chc1-521.

INP52 genes

alpha-factor

alpha-factor


Input: The complete nucleotide sequence of odontoglossum ringspot virus (Cy-1 strain) genomic RNA.


Input: Paradoxically there is a decrease in the level of soluble A beta secreted from the cells.

soluble A beta


Input: When translated in-frame with PKC zeta, a stop codon is located 28 amino acids towards the N-terminus of the divergence point and the intervening sequence lacks an expected initiating methionine. psi PKC zeta is non-functional in terms of protein synthesis since Western blotting with an antibody directed against the C-terminus of PKC zeta failed to reveal a protein smaller than PKC zeta, and synthetic psi PKC zeta RNA failed to support protein synthesis in a translation system in vitro.

PKC zeta

psi PKC zeta

PKC zeta

PKC zeta

psi PKC zeta RNA


Input: Comparative ultrafiltration (UF) studies with BiGG and standard lactate (La) solutions in rabbits showed that net UF with La solution peaked at 2 h and decreased significantly at 4 h and 6 h.


Input: The B. aphidicola argS-rrn DNA fragments from endosymbionts from seven species of aphids had promoter activities in E. coli which ranged from 6 to 135% of that observed with a comparable DNA fragment of E. coli rrnB.

B. aphidicola argS-rrn DNA fragments

E. coli rrnB


Input: CONCLUSIONS: These principally structural studies support the hypothesis that the thrombus is a self-sustaining entity that may have significance in the pathophysiologic mechanism of abdominal aortic aneurysms.


Input: The authors report about the exeresis of a pyelonephrictic left small kidney with laparoscopic surgery.


Input: AMPK is a heterotrimer composed of a catalytic subunit (alpha) and two regulatory subunits (beta and gamma).

AMPK


Input: The genes encoding these carotenoids in E. herbicola Eho13 are clustered in a 7 kb DNA fragment.


Input: Genetic diagnosis of respiratory diseases


Input: Whereas mutant 6C4 specified a wild-type-size Pol protein, we detected no full-length Pol protein in 7E4-infected cell extracts.

mutant 6C4

wild-type-size Pol protein

full-length Pol protein


Input: Incidence of beta-thalassemia carriers and those deficient in erythrocyte glucose-6-phosphate dehydrogenase in the greater Buenos Aires area

erythrocyte glucose-6-phosphate dehydrogenase


Input: Other toxicities attributed to CPT-11 included dehydration, nausea, vomiting, and asthenia.


Input: JCAHO moves to rewrite many rules to lessen hospitals' regulatory burden.


Input: A phylogenetic comparison of 32 species showed minor differences in the apoB mRNA sequence, and the apoB mRNA from 31 species was robustly edited in vitro.

apoB mRNA sequence

apoB mRNA


Input: The expression pattern of the reporter gene was compared to that of the endogenous PDGFbeta r gene.

endogenous PDGFbeta r gene


Input: These transcripts directed the synthesis of three proteins: the virus trans-activator protein (EIAV Tat) encoded by ORF S1, a protein of unknown function encoded by ORF S2, and the virus envelope glycoprotein.

virus trans-activator protein

EIAV Tat

envelope glycoprotein


Input: In addition, because SB203580 had no effect of TNF-or ceramide-induced apoptosis, our results strongly argue against a role for p38 MAPK in the induction of TNF--or ceramide-induced apoptosis.

TNF

p38 MAPK

TNF


Input: Seven Zebu cattle were also exposed to challenge at the same time.


Input: To study the signaling pathways that regulate cytoskeletal rearrangements in T lymphocytes, we set up a conjugate formation assay using Jurkat T cells as effectors and cell-sized latex beads coated with various antibodies as artificial APCs.


Input: YACs, BACs, cosmids, and STSs are defined to aid in further study of this gene.


Input: The average coefficient of variation between assays for gas chromatography mass spectrometry was 5. 8% and for radioimmunoassay was 12. 3%, while the average coefficient of variation within assays for gas chromatography mass spectrometry was 4. 9% and for radioimmunoassay 6. 9%.


Input: This chimera transduced IL-4-specific signals in response to IL-2 binding and dramatically enhanced type 2 responses (IL-4, IL-5, and immunoglobulin E production) upon in vitro TCR stimulation or in vivo antigen challenge.

immunoglobulin E

TCR


Input: Soggy, a spermatocyte-specific gene, lies 3. 8 kb upstream of and antipodal to TEAD-2, a transcription factor expressed at the beginning of mouse development.

Soggy


Input: We previously demonstrated that AKT2, a member of protein kinase B family, is activated by a number of growth factors via Ras and PI 3-kinase signaling pathways.

protein kinase B family

Ras

PI 3-kinase


Input: This demonstrates the presence of a PKC-dependent pathway which functions independently from Lck in MAP kinase activation.

PKC

Lck

MAP kinase


Input: Finally, transfection of Grb10 genes with specific mutations in their SH2 domains induces apoptosis in HTC-IR and COS-7 cells.

Grb10 genes

SH2 domains


Input: Small t also inhibited the dephosphorylation of cAMP-dependent protein kinase (PKA)-phosphorylated CREB in rat liver nuclear extracts.

Small t

cAMP-dependent protein kinase

PKA

CREB


Input: Physical map of the genome of sonchus yellow net virus, a plant rhabdovirus with six genes and conserved gene junction sequences.


Input: It is an untested argument that conventional beta-adrenoceptor antagonists possess unwanted metabolic effects that may counter some of their potential cardiac benefits.

beta-adrenoceptor


Input: However, it is not easy to establish the diagnosis of thoracic MFH.


Input: An 11. 5-kb intron is found at the end of transmembrane 6, and the rest of the ORF is in exon 3.


Input: To assay for sequences that could potentially regulate Xenopus proenkephalin expression, we transfected constructs that contained upstream genomic sequences linked to the CAT reporter gene into various eukaryotic cell lines.

Xenopus proenkephalin

CAT reporter gene


Input: It is also conceivable that elevated insulin levels may cause hypertriglyceridaemia and possibly other abnormalities of lipid metabolism.

insulin


Input: The effects of different sources of commercial rations on the humoral immune response of broilers to Newcastle disease vaccination.


Input: To quantify the normal coupling patterns, fresh cadaveric human lumbar spine specimens (L1-S1) were used.


Input: Deletion mutations were constructed, removing residues 2-30, 31-60, 61-90, and 49-78 of the N-terminal cytoplasmic domain, as well as a missense mutation of a dileucine motif.


Input: When the measured beta-galactosidase activity in the pWP-transfected cells was normalized to the pCH110-transfected cells (an appropriate control if the SV40 early region promoter functions constitutively in various cell lines), the results suggested that the promoter region of the PLP gene contains the information necessary for initiation of transcription in a C6 cell-specific manner.

beta-galactosidase

SV40 early region promoter

PLP gene


Input: Indigenous microbial flora and the large intestine in tadpoles.


Input: 3 patients with acute leukaemia, HLA antibodies and thrombocytopenia refractory to random donor platelet transfusions were treated with high-dose i. v. immunoglobulin.

HLA

immunoglobulin


Input: Plasma renin activity in end-stage kidney disease.

Plasma renin


Input: Computer system trains employees to meet JCAHO safety ED requirements.


Input: The temporal sequence of organ failure was lung, clotting system, kidney, and liver.


Input: All of this region is part of a prominent CpG island that may be acting as an extended, enhancer-independent promoter.


Input: One function of p53 is in regulating cell cycle check-point control after DNA damage.


Input: IGF-I levels were measured in the CSF of 11 children with autism (4 females, 7 males; mean age 3. 8 years, SD 1. 1) using a sensitive radioimmunoassay method and compared with levels in 11 control participants (6 females, 5 males; mean age 3. 8 years).

IGF-I


Input: The XPR2 gene from Yarrowia lipolytica encodes an inducible alkaline extracellular protease.

XPR2 gene

alkaline extracellular protease


Input: Two closely related groups of transcripts, Sagrp1 and Sagrp2, controlled by a circadian rhythm have been isolated.


Input: In patients autografted in CR1, the transplant-related mortality (TRM) was 15 +/-4%, the relapse incidence (RI) was 58 +/-5%, the leukaemia-free survival (LFS) was 36 +/-5% and the overall survival was 47 +/-5% at 3 years.


Input: However, H19 and IGF2 lie within a larger imprinted domain, and the gene specificity of H19 epimutation has been a persistent question.


Input: Antibiotics and CDCA-mediation are essential for symptomatic therapy.


Input: The effectiveness and pathogenetic expediency of correcting disorders of lipid metabolism in atherosclerosis with enterosorbents is substantiated.


Input: Adaptive effects of repeated immersion exposure on the human body


Input: The human cDNA was cloned and sequenced; it was shown to have an open reading frame encoding a 296-amino-acid protein in which could be identified four peptides previously identified by micro-sequencing purified protein.


Input: Octamer recognition is mediated by the POU domain, a conserved structural motif which--like the zinc finger and leucine zipper--defines a family of related transcription factors.

POU


Input: Copyright 1998 The Association for the Study of Animal Behaviour.


Input: Dipetalonema (Acanthocheilonema) didelphis sp. n.


Input: Forty-five patients with recent-onset hyperthyroidism (< 12 weeks) were sex and menopause stratified and randomly allocated to treatment with carbimazole (Neotomizol), carbimazole plus low dose CT (Calsynar; 100 IU/day, 2 days/week), or carbimazole plus high dose CT (Calsynar; 100 IU/day, 14 days/month).


Input: The promyelocytic leukemia protein interacts with Sp1 and inhibits its transactivation of the epidermal growth factor receptor promoter.

promyelocytic leukemia protein

epidermal growth factor receptor


Input: CTP, GDP, GTP, ITP) did not affect the response.


Input: Here, we characterize TCR/CD48 and TCR/CD28 costimulation in T cells expressing Lck Src homology 3 (SH3) mutants.

TCR

TCR

Lck Src homology 3


Input: We also show that psbH and psbT are transcribed from the upstream psbB gene promoter, and that the psbH mRNA has its own target sequence for Mbb1 function.

psbH

psbT

psbB gene promoter

psbH mRNA


Input: Thus, it appears that moxalactam is a reliable and useful antibiotic for the treatment of complicated urinary tract infections.


Input: In the second, 37 students were given trimethoprim/sulphamethoxazole (160 mg TMP-SMX 800 mg), 38 TMP (200 mg), and in 35 a placebo was given b. i. d. for five days.


Input: CONCLUSION: Men presenting with urethritis and women presenting with PID both have significantly greater peripheral blood mononuclear cell proliferative responses to the DK20 strain of C trachomatis than controls.


Input: The infection of cells with Moloney murine leukemia virus (M-MuLV) causes an increase in specific cellular gene products, including the major histocompatibility complex (MHC) class I antigens.

major histocompatibility complex (MHC) class I antigens


Input: Apparent Buschke-Loewenstein tumour of the penis.


Input: The orthologs of the Y (1) and Y (2) subtypes display high amino acid sequence identities between pig, human, and mouse (92%-94%), whereas the Y (4), Y (5), and y (6) subtypes display lower identities (76%-87%).

Y (1)

Y (2) subtypes

Y (4)

Y (5)

y (6) subtypes


Input: In NIH 3T3 fibroblasts the high affinity IL-2R bearing a deletion of a region rich in acidic amino acids (the " acidic " region) in the IL-2R beta-chain failed to induce the tyrosine phosphorylation of MAP kinase as well as the expression of the all three nuclear proto-oncogenes.

IL-2R beta-chain

MAP kinase


Input: Activation of the cytotactin promoter by the homeobox-containing gene Evx-1.

cytotactin promoter

homeobox-containing gene Evx-1


Input: Of the private practices accredited in August 1995, 40. 6 per cent (122) participated.


Input: Enhanced phospholipid hydrolysis with free fatty acid and thromboxane accumulation, increased release of excitatory amino acids, and decreased tissue magnesium levels may each serve to worsen secondary tissue damage and diminish neurologic recovery after spinal cord injury associated with acute alcohol intoxication.


Input: This suggests that the ratio of IL-6 to IL-10 may be used to predict the injury severity after trauma.


Input: With six reports in the literature that show there is an order to melanoma nodal metastases and that the SLN histology is reflective of the histology of the remainder of the nodal basin, the more conservative SLN biopsy can be performed to adequately stage nodally the patient with melanoma.


Input: In addition, a double mutant (E482A, D489A) which removed negative charges along one side of the helix had negligible effects on fusion activity.


Input: Escherichia coli cells expressing a mutant glyV (glycine tRNA) gene have a UVM-constitutive phenotype: implications for mechanisms underlying the mutA or mutC mutator effect.

mutant glyV

glycine tRNA

mutA

mutC mutator


Input: Titres of antistreptolysin O in mothers of children affected with Down' s syndrome.

antistreptolysin O


Input: Synthetic studies on furan derivatives by the wittig reaction


Input: Positive linear correlations were found when the AUC (0-12) (r = 0. 68; P less than 0. 01), the maximum plasma concentration (r = 0. 34; P less than 0. 01), the minimum plasma concentration (r = 0. 55; P less than 0. 01), and the elimination t1/2 (r = 0. 46; P less than 0. 01) were regressed with age.


Input: Furthermore, the social learning theory of depression, developed by Lewinsohn, is described.


Input: Intramolecular interaction is believed to result in the formation of MxA monomers, whereas intermolecular interaction may induce the formation of large MxA oligomers.

MxA monomers

large MxA oligomers


Input: Analysis of a Het-mutation in Anabaena sp. strain PCC 7120 implicates a secondary metabolite in the regulation of heterocyst spacing.

Het


Input: He presented with left lower abdominal pain and hematoma after a fall.


Input: To this end we generated a detailed physical map of the genomic region spanning between sequence-tagged site markers D16S518 and D16S516.


Input: The kinetics of erythromycin (E.) was studied in 16 patients with different degrees of impairment of renal function after a single intravenous dose.


Input: Lasting paraplegia caused by loss of lumbar spinal cord interneurons in rats: no direct correlation with motor neuron loss.


Input: Gold flaxseed (whole or ground) fed at levels of 5 or 15% were compared to a 1. 5% menhaden oil or a typical control layer ration.


Input: The study drugs (combination vinblastine-CCNU and single-agent triazinate or dactinomycin) failed to provide any meaningful antitumor activity for these patients with advanced renal cell cancer.


Input: Some CHOP-C/EBP heterodimers apparently bind to alternative DNA sequence and thereby regulate the transcription of other genes.

CHOP

C/EBP


Input: Furthermore, addition of the recombinant NF-YA subunit restores NF-Y binding.

recombinant NF-YA subunit

NF-Y


Input: Our data provide the first evidence that differential splicing in the extracellular region of a receptor gene generates receptor variants with different ligand-binding specificities.


Input: Intrathecal injections of small volumes of the alpha 2-adrenoceptor agonists, xylazine and clonidine, into the cervical region of the spinal cord of conscious unrestrained sheep produced a dose-dependent analgesia of the forelimbs as measured using a mechanical pressure device.

alpha 2-adrenoceptor


Input: The specificity of the transcriptional activation by ISGF3 is mediated by specific elements termed IFN-stimulatory response element (ISRE) located in the promoter region of IFN-inducible genes.

IFN-stimulatory response element

ISRE

IFN


Input: Clinical development of interleukin-10.


Input: Estrogen has positive effects on mood, sexual function, target end organs and cognitive function, and may play an important role in the etiology of Alzheimer' s Disease by acting to prevent amyloid plaque formation, oxidative stress, or deterioration of the cholinergic neurotransmitter system.


Input: The system consists of a microcomputer and six laboratory analyzers: a blood gas analyzer, a flame photometer, a plasma osmotic pressure meter, a chloride ion titrator, a blood sugar analyzer, and a hemoglobin concentration and saturation meter.

hemoglobin


Input: Of these, 23 (13. 6%) were due to GIB (Upper GIB = 19, Lower GIB = 4).


Input: Hence the GAP1 gene encodes a protein with characteristics typical of integral membrane proteins translocating ligants across cellular membranes.

GAP1 gene


Input: Soluble fibrin monomer complexes in thromboembolism

fibrin


Input: S16, 16. 8%, P = 0. 001).


Input: Microenvironments dominated by cyanobacteria (BPC) had a higher pH (pH 7-8) than those dominated by lichen (LTL) (pH 4. 5-5. 5).


Input: Saturated fatty acids induce a 1. 6-fold increase in transcription activity, whereas a large family of unsaturated fatty acids repress OLE1 transcription as much as 60-fold.


Input: A third GEF, GRP3 (KIAA0846), activated both Ras and Rap1 and shared significant sequence homology with the calcium-and diacylglycerol-activated GEFs, GRP1 and GRP2.

GEF

Ras

GEFs


Input: We have determined the molecular organization and transcription start points (tsp) for the murine gene (TK) encoding thymidine kinase.

TK

thymidine kinase


Input: Effect of gentamycin on the kidney functional state in experimental pyelonephritis


Input: The time-dependent changes in measured facility of outflow or " washout phenomenon " appeared to result from the gradual dissolution of the hyaluronidase-sensitive component of the barriers to aqueous outflow in the canine eye.

hyaluronidase


Input: Melioidosis in Sika deer (Cervus nippon nippon).


Input: Many human malignant cells lack methylthioadenosine phosphorylase (MTAP) enzyme activity.

methylthioadenosine phosphorylase

MTAP


Input: Nucleocapsid structure and thermostability of the virion, nucleocapsid and polymerase complex.


Input: We propose 2 separate PAI-1 inductory pathways for PMA and IL-1alpha in HepG2, both involving protein tyrosine kinase activation; the serum-induced signaling pathway may (partially) overlap with the PMA-activated protein kinase C/mitogen-activated protein kinase kinase pathway, leading to c-Jun homodimer binding to the PAI-1 TRE.

protein tyrosine kinase

protein kinase C

mitogen-activated protein kinase kinase

c-Jun homodimer


Input: Crude drugs from aquatic plants.


Input: Recurrence of the hepatic cyst after partial excision and drainage was complicated by fistula formation between the cyst and the duodenum.


Input: These data show that tyrosine phosphorylation by FES affects the interaction of BCR with multiple signaling partners and suggest a general role for BCR in non-receptor protein-tyrosine kinase regulation and signal transduction.

FES

BCR

BCR

protein-tyrosine kinase


Input: Reversal of' refractory septic shock' by infusion of amrinone and angiotensin II in an anthracycline-treated patient.

angiotensin II


Input: Replication regions from plant-pathogenic Pseudomonas syringae plasmids are similar to ColE2-related replicons.


Input: Comparison of dose volume histograms revealed that the 6-field plan spared relatively more heart whereas the 8-field plan spared relatively more lung.


Input: STUDY OBJECTIVE: to characterize gas exchange and cardiopulmonary performance during maximal progressive arm crank exercise.


Input: At 9 months postpartum, serum fT4 and fT3 levels were low normal (8. 0 and 1. 7 pmol/L, respectively), but TSH was not raised (0. 4 mU/L).

TSH


Input: The most frequent abnormality was GH deficiency (six cases), followed by gonadotropin (four cases), cortisol (four cases), and TSH (one case), whereas four patients showed high serum PRL values.

GH

gonadotropin

TSH

serum PRL


Input: In the normal controls the plasma FPA level (mean +/-SD) was 1. 43 +/-0. 46 ng/ml.

plasma FPA


Input: The nramp2 gene is comprised of 17 exons and spans more than 36 kb.

nramp2 gene


Input: Studies on recurrences in gingival hyperplasia


Input: BACKGROUND: In lung protective strategy, positive end-expiratory pressure (PEEP) slightly higher than the Pflex (the airway pressure corresponding to the lower inflection point (LIP) on the inspiratory pressure-volume (P-V) curve measured with ZEEP) is generally recommended.


Input: Effect of a constant magnetic field on different models of carcinogenesis


Input: FACS analysis demonstrated that MCs had reached middle to late G1 phase of cell cycle progression at this timepoint.


Input: Nuclear export of proteins in plants: AtXPO1 is the export receptor for leucine-rich nuclear export signals in Arabidopsis thaliana.


Input: Strains carrying a snf1 mutation are unable to grow on sucrose, galactose, maltose, melibiose, or nonfermentable carbon sources; utilization of these carbon sources is regulated by glucose repression.

snf1 mutation


Input: Similarly, beta adrenoceptors blockade has been shown to be of value in achieving continence in a small group of patients.

beta adrenoceptors


Input: The contractile effects of oxytocin, prostaglandin F2 alpha and their combined use on human pregnant myometrium were studied in vitro.

oxytocin


Input: Effectively, the upstream, housekeeping-type promoter responds to FIXK and positively regulates the downstream, sigma 54-type promoter.

FIXK

sigma 54-type promoter


Input: Km values of the uncoupled enzymes IIGlc for glucose ranged from 0. 5 to 2. 5 mM, 2 orders of magnitude higher than the value of normal IIGlc.

IIGlc

IIGlc


Input: Measurement of protein in natural rubber latex.


Input: Disruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger-dependent cryptic transactivator function of PML.

PML subnuclear domains

acidic IE1 protein

PML

PML


Input: The fate of ochratoxin A during malting and brewing.


Input: To further investigate the role of PKR in transcriptional signaling, we expressed the wild type human PKR and a catalytically inactive dominant negative PKR mutant in the murine pre-B lymphoma 70Z/3 cells.

PKR

wild type human PKR

PKR mutant


Input: Consistent with other experiments with these compounds, cocaine was the most potent of the group.


Input: Atrial dissociation.


Input: It is envisaged that the WHOQOL-BREF will be most useful in studies that require a brief assessment of quality of life, for example, in large epidemiological studies and clinical trials where quality of life is of interest.


Input: Hepatitis B immune globulins and HIV antibodies.

Hepatitis B immune globulins

HIV antibodies


Input: One cytoplasmic target which reflects the functional state of the plastids is protein kinase C.

protein kinase C


Input: A 360-bp DNA fragment located over 500 bp upstream from the cfl transcriptional start site was used in DNase I protection assays to define the specific bases bound by CorR.

cfl

DNase I

CorR


Input: A relationship between the immunological changes and the disease stage was discovered: the index of the 3H-thymidine incorporation was found to be 67. 9 at the stage of disease exacerbation, and 208. 8 at the stage of remission; the complement titre reached, respectively, 46. 64 +/-5. 28 and 112. 0 +/-6. 0 units per ml.


Input: In the spontaneous abortion group, the levels of PAPP-A were significantly lower than in normal pregnancy but higher than in non-pregnant controls.

PAPP-A


Input: Maximum likelihood estimation in covariance structure analysis with truncated data.


Input: The gene encoding rat peptidylglycine alpha-amidating monooxygenase (PAM) contains 26 protein-coding exons.

peptidylglycine alpha-amidating monooxygenase

PAM


Input: Whether this lack of preferential repair has to be explained by a defect in repair or in general transcription is unclear at present.


Input: Pretreatment of human skin with tRA inhibited UV induction of c-Jun protein and, consequently, AP-1. c-Jun protein inhibition occurred via a posttranscriptional mechanism, since tRA did not inhibit UV induction of c-Jun mRNA.

c-Jun protein

c-Jun protein

c-Jun mRNA


Input: MUS81 encodes a novel helix-hairpin-helix protein involved in the response to UV-and methylation-induced DNA damage in Saccharomyces cerevisiae.

helix-hairpin-helix protein


Input: All possessed cutaneous receptive fields on the distal segments of digits 2, 3, or 4.


Input: In situ hybridization reveals strong signals for Zep mRNA in the cerebellum and olfactory bulb with moderate signals detected in the hippocampus and cortex.

Zep mRNA


Input: A series of sequence fragments were placed 5' to the chloramphenicol acetyltransferase (CAT) reporter gene and ability to mediate transcription of CAT in response to IFN gamma or LPS treatment was studied following transient transfection in the macrophage-like cell line RAW 264. 7.

chloramphenicol acetyltransferase

CAT

CAT

IFN gamma


Input: A GT-rich sequence binding the transcription factor Sp1 is crucial for high expression of the human type VII collagen gene (COL7A1) in fibroblasts and keratinocytes.

transcription factor Sp1

human type VII collagen gene


Input: Using in vivo genomic dimethyl sulfate and KMnO4 footprinting, we showed that the promoter region is differentially protected, depending upon which holoenzyme is bound.


Input: We conclude that these cDNAs belong to a novel GST class hereby designated Kappa, with the rat GST subunit 13 gene designated rGSTK1 and the human gene being called hGSTK1.

GST

rat GST subunit 13 gene


Input: At onset of first post-weaning estrus, sows received either an intravulval injection of 3. 75 mg of prostaglandin analogue (PGF) or, served as a non-injected control (CON).


Input: Tbx6 maps to chromosome 7 and does not appear to be linked to any known mutation.


Input: Before therapy was started, trabecular bone alterations could be observed which were typical for Paget' s disease of bone as there were bulky trabeculare, increased remodelling surfaces and giant osteoclasts.


Input: At 11. 5 years of follow-up, 521 major coronary disease events had occurred, 261 fatal and 260 non-fatal.


Input: However, additional studies on cell lines and whole animals are required to understand GnRH signaling in the context of other hormones during the reproductive cycle of mouse and human.

GnRH


Input: Total meso-pore volume and surface area ranged from 0. 004-0. 08 cm3 g (-1) and from 0. 33-6. 9 m2 g (-1) respectively, accounting for up 33% of the BET surface area.


Input: Contraindications to adenosine and drug interactions are noted in this article.


Input: The extent of the odontoblast process in human dentin.


Input: On transfer from glucose, succinate, malate, or glycerol medium to citrate medium, the Cit + Escherichia coli strains showed a delay of 36 to 48 h before growth.


Input: The index patient, a 10-year-old boy, presents typical symptoms of OPD type I together with bowing of the long bones and abnormalities of the thorax and spinal column.


Input: After enzymatic hydrolysis of the water soluble fraction, it is shown that 28% is again extractable by DCM of which 57% consists of unchanged SC4453 which is therefore the main partner of conjugated products.


Input: Additionally, the members of this family display strong sequence homologies between their larger C-terminal effector binding/oligomerization domains.


Input: Microalbuminuria: a marker of systemic disease.


Input: Long-term ambulatory measurement of transcutaneous arterial CO2 pressure (PCO2) offers an opportunity to test directly the co-occurrence of panic and hyperventilation under natural conditions.


Input: An association was found between zafirlukast plasma concentrations and increases in PC8SRaw 10 h after treatment (p = 0. 001).


Input: Most interestingly, although the effector plasmid containing the ICP27 gene had little effect on its own, two different and marked effects depending on the target were observed when ICP27 was combined with ICP4 or ICP0 or both.

ICP27 gene


Input: Water pair and three-body potential of spectroscopic quality from Ab initio calculations


Input: Because the wa-2 mutation was mapped previously to the vicinity of the EGF/TGF-alpha receptor (EGFR) gene on mouse chromosome 11, we hypothesized that the wa-2 phenotype might result from a defect in either the expression or activity of EGFR, or both.

wa-2 mutation

EGF/TGF-alpha receptor

EGFR

wa-2 phenotype

EGFR


Input: 4) Mutation of the three extracellular cysteine residues of GFKAR beta indicated that the two conserved cysteine residues (C305 and C385), located between two transmembrane segments, form a solvent-accessible disulfide bond.

GFKAR beta


Input: R of the chest wall was maximum (35. 6 cmH2O. L-1. sec-1 +/-2. 2 SE) at 0. 2 Hz-10 ml and decreased with increasing f and VT, although the VT effect diminished at the higher f.


Input: Time dependence of frequency potentiation in the isolated guinea-pig' s atrium.


Input: Comparison of the predicted amino acid sequence with that of the Drosophila virilis gene shows that several blocks of amino acid sequence have been very highly conserved.

Drosophila virilis gene


Input: The N-terminal exon1 had no homology at the amino acid level with NGFI-B, the mammalian homologue.

NGFI-B


Input: Although RAD17, RAD24 and MEC3 are not required for cell cycle arrest when S phase is inhibited by hydroxyurea (HU), they do contribute to the viability of yeast cells grown in the presence of HU, possibly because they are required for the repair of HU-induced DNA damage.


Input: Single oblique-view mammography for periodic screening for breast cancer in women.


Input: Conventional toxicological considerations suggest that the adverse health effects of any necessary increase in coal combustion effluents would be greatest per unit of coal in those areas which are most heavily populated and have the highest preexisting levels of the gas-aerosol complex.


Input: The arterial blood pressure was measured by using bloody method in anesthizied animals.


Input: Nicotinic receptor antagonists mecamylamine (0. 5 and 1 mg/kg) and hexamethonium (5 and 10 mg/kg) reduced the response induced by nicotine (0. 25 mg/kg).

Nicotinic receptor


Input: The present work represents an attempt to develop a method for measuring relative blood flow in intestinal capillaries, by the use of sodium fluorescein (Na-F) as an indicator substance.


Input: The matrix of the CBs contains the diagnostic protein p80-coilin, which is colocalized with the U7 small nuclear ribonucleoprotein (snRNP), whereas the attached and embedded B-snurposomes contain splicing snRNPs.

coilin

U7 small nuclear ribonucleoprotein


Input: Tritium concentrations in environmental water samples were found to be determined within an accuracy of 10% by this method when Vi/Vf was 14-25.


Input: The results of this study suggest that in patients with syndrome X, myocardial ischemia frequently develops during daily life; silent ischemia is an important component of this syndrome; and increased oxygen demand in the presence of impaired coronary vasodilatory capacity is not the only cause of myocardial ischemia.


Input: Two patients with Ewing' s sarcoma relapsed (1 patient with both local and distant failure) at 26 and 58 months and were again rendered disease-free with surgery, total body irradiation and further chemotherapy.


Input: In this study, the subcellular location, domain structure, and biochemical function of metaxin were investigated.

metaxin


Input: Long-term renal function in on-heart-beating donor kidney transplantation: a single-center experience.


Input: When single-point mutation was introduced to each GC box, EBS, and GT box in PFP9a20, at least 3-fold less CAT activity was observed in CTLL-R8 cells.

EBS

CAT


Input: Thirty-three percent had elevated titers (above 1: 20 dilution).


Input: There is, however, uncertainty as to how results obtained in recent experiments scale up to landscape and regional levels and generalize across ecosystem types and processes.


Input: Chest X-P revealed an abnormal shadow in the left upper lobe.


Input: Despite these high initial rates of transcription, of all the promoter constructs only LAT-LTR was able to remain transcriptionally active after the establishment of a latent state.

LAT


Input: Unestablished quail myoblasts were infected with a retroviral vector encoding the oncogenic form of H-Ras in order to investigate the mechanism by which this oncoprotein interferes with terminal differentiation.

H-Ras


Input: Exhaled NO was assessed by controlled-flow chemoluminescence after adjusting for trapped air and after generating pressure in the oral cavity that was sufficient to close the soft palate (Eco Physics CLD 77 AM analyzer).


Input: SATB1 interacted with CDP through its DNA-binding domain, as demonstrated by glutathione S-transferase (GST) pull-down assays.

CDP

glutathione S-transferase

GST


Input: Both the inactive domain II P68 mutant and the deletion mutant lacking aa 91-243 were less inhibitory to growth in yeast due to the reduced ability to phosphorylate initiation factor 2 alpha in vivo.

domain II P68 mutant

initiation factor 2 alpha


Input: Applying the experience mentioned above, 4-META was used to bond a proprietary photocuring microfilled composite material to Class V cavities in freshly extracted human teeth.


Input: As the mechanism of the intractability, cell function involved in the defense against infection was evaluated.


Input: IV.


Input: A Premenstrual Syndrome, the late luteal phase disorder of DSM-IIIR criteria, was identified in 6% of the women.


Input: After 5-h thermal induction of cells carrying the runaway recombinant pBS1, protein B2 constituted 40% of the soluble protein fraction of the cells.

protein B2


Input: These results indicate that patients with SS and evidence of exercise-induced ST-segment depression may have decreased myocardial oxygen supply due to low hemoglobin levels and increased myocardial oxygen demand (elevated double products) when compared to subjects with SS who do not have exercise-induced ST-segment depression.

hemoglobin


Input: The highest concentration of respirable mineral fibres was found during the overhaul of a truck with asbestos insulation; respirable fibre concentration reached the value of 5 f/cm3, and total dust concentration-the value of about 80 mg/m3.


Input: Changes in the size and organisation of the brain in man and his ancestors.


Input: Mechanisms of action of local anaesthetics.


Input: Gastric secretory inhibition induced by three methyl analogs of prostaglandin E2 administered intragastrically to man.


Input: By contrast, footprint II at position-125 is common to both HeLa and GH3 cell extracts and overlies a 15-base-pair sequence found in all members of the growth hormone gene family.

growth hormone gene family


Input: DNA sequence of the UL6 to UL20 genes of infectious laryngotracheitis virus and characterization of the UL10 gene product as a nonglycosylated and nonessential virion protein.

UL20 genes

UL10 gene product


Input: Unlike LANA1, LANA2 does not elicit a serologic response from patients with KS, PEL, or CD as measured by Western blot hybridization.


Input: CD4 degradation mediated by Vpu does not require the ER chaperone calnexin and is dependent on an intact ubiquitin-conjugating system.

Vpu

calnexin

ubiquitin


Input: A deletion analysis of the FAS1 promoter lacking the previously characterized inositol/choline-responsive-element motif defined a region (nucleotides-760 to-850) responsible for most of the remaining activation potency.

FAS1 promoter


Input: Promoter constructs containing mutations in the PTRE sequence that selectively abolished the binding of either one or both complexes exerted opposite effects on the transcriptional activity of trypsin promoters in A. gambiae and Aedes aegypti cell lines.

PTRE sequence

trypsin promoters


Input: This preliminary study reports an initial evaluation of HMPAO-SPECT imaging for assessing regional alterations in brain function during opiate dependence and withdrawal.


Input: The revaluation at the end of the study showed a good compliance for the proposed diet scheme by children, but a poor compliance by their families.


Input: Cytostatic activity of some essential oils against HEp-2 cells.


Input: Custom-made orthoses play an invaluable role in achieving a wide range of therapeutic goals: improving function and pinch, stabilizing individual joints, preventing positional contractures, protecting joints from trauma, stretching the intrinsic muscles, correcting joint-and soft-tissue contractures, and controlling inflammation.


Input: Excess recombinant PTB squelches the splicing switch and reestablishes exon skipping as the predominant splicing pathway.

recombinant PTB


Input: Among women, plasma factor VII: Ag was inversely associated with income.

plasma factor VII


Input: We concluded that these results support the feasibility and usefulness of N-of-1 RCT in rheumatology practice.


Input: K562 erythroleukemia cells stably transfected with constructs containing the human Agamma-globin promoter linked to an enhanced green fluorescent protein (EGFP) reporter, with or without HS2, were analyzed for EGFP expression by flow cytometry.

human Agamma-globin promoter

enhanced green fluorescent protein

EGFP

EGFP


Input: Recently, we demonstrated that platelet-derived growth factor (PDGF)-beta receptor stimulation, but not various other growth factors, inhibits transcription of alpha1D-, but not alpha1A-or alpha1B-ARs, resulting in reduced norepinephrine-mediated SMC growth.

platelet-derived growth factor (PDGF)-beta receptor


Input: (A short account of Karl Touton' s life is also included.) After reviewing the historical development of the concept of giant cells and current interpretations of their nature, the unitarian view of polykaryons now favored by workers in the field is extended to include also the " xanthelasmatic giant cell " of Touton, whose characteristic appearance is determined merely by the presence of demonstrable lipid in the cytoplasm.


Input: It has also been previously demonstrated that LPS treatment of splenic B cells from athymic mice results in a decrease in steady state mRNA encoding the A alpha class II protein.

A alpha class II protein


Input: After birth, there was a significantly higher increase of IgA and IgM anti-M. leprae antibody activity in sera taken 3-6 months after birth from babies of Group 1 compared to Group 2, but the IgA and IgM activity in sera taken after 6 months of age showed the same increase in the two groups.

IgA

IgM anti-M. leprae antibody

IgA

IgM


Input: Serum estriol levels during beta-receptor agonist infusion in the third trimester of pregnancy.

beta-receptor


Input: These tiny premature infants also received PN for significantly longer periods of time, and the longer the infusions were administered the greater was the risk of cholestasis developing.


Input: We show that sae1-1 and sae3-1 mutations each confer a distinct defect in meiotic recombination. sae1-1 produces recombinants but very slowly and ultimately to less than half the wild-type level; sae3-1 makes persistent hyper-resected meiotic double-strand breaks and has a severe defect in formation of recombinants.

sae3-1 mutations


Input: Patients in the mucinous cyst group had significantly lower CA 125 cystic fluid levels compared with women with endometriomas and dermoids (P & lt; 0. 05).

CA 125


Input: The brains were processed according to the tetramethylbenzidine (TMB) protocol of Mesulam (' 78) and studied with darkfield microscopy.