Input: We describe a novel stat-related factor, p93, that is found in EGF-treated A431 cell extracts but appears to be absent in bovine fibroblast growth factor (bFGF), IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), and untreated cells. p93 appears to be antigenically related to stat91. p185c-neu +, EGFr + (M1), and p185c-neu-kinase inactive, EGFr + (NEN757) expressing cells undergo different mitotic responses to EGF.

stat-related factor

EGF

bovine fibroblast growth factor

bFGF

IFN-gamma

tumor necrosis factor-alpha

TNF-alpha

neu

EGFr +

neu

EGFr +

EGF


Input: MRI measurements of the brain.


Input: Phosphorylation by Cdc28 activates the Cdc20-dependent activity of the anaphase-promoting complex.


Input: Phosphorylated tyrosine residues were subsequently identified by sequencing the separated phosphopeptides by matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) and Edman degradation.


Input: Superovulation with intrauterine insemination (SO-IUI) has been suggested as an alternative to gamete intrafallopian transfer (GIFT), despite the absence of controlled or comparative trials.


Input: One of these elements resembles the binding site of a previously identified cellular " transcription " factor.


Input: The Rep78 protein of adeno-associated virus (AAV) contains amino acid sequence motifs common to rolling-circle replication (RCR) initiator proteins.

Rep78 protein

rolling-circle replication (RCR) initiator proteins


Input: METHODS: CD4 cell counts and interview data were recorded in a survey of 136 adult patients attending a community hospital-based HIV outpatient clinic.


Input: Based on 29 determinations of the glucose from sinigrin, analyzed under different conditions, accuracy of the total glucosinolate determination was 94. 8 +/-7. 3%.


Input: Transcriptional analysis of this gene cluster was performed by detecting the presence of mRNAs spanning adjacent genes as well as by using a promoterless lacZ reporter gene fused to each of the seven genes contained in the tol-oprL locus.

lacZ reporter gene

tol

oprL


Input: The regions encoding the mature proteinases were cloned into an expression vector and recombinant protein produced in Escherichia coli.


Input: H.


Input: Rhinovirus 2A protease and foot-and-mouth-disease virus L protease were used to analyze the association of eIF4G with eIF4A, eIF4E, and eIF3.

Rhinovirus 2A protease

foot-and-mouth-disease virus L protease


Input: METHODS: Two patients developed cervical myelopathy or radiculopathy after spinal manipulation therapy, and magnetic resonance imaging showed herniated cervical discs at C4-C5 and C6-C7, respectively.


Input: This increased frequency of infection has been accompanied by significant excess mortality.


Input: One of the repeating domains (Yheb1), consisting of 67 amino acids, was cloned from the E. coli chromosome and purified by metal chelating chromatography.


Input: Assessment of two anion-exchange resins for direct use in the screening method for urinary porphobilinogen.


Input: These studies define a class of DNA elements with a mode of action that has not been heretofore described.


Input: Using lacZ-inducible T cells as a probe, we screened a splenic cDNA library in transiently transfected antigen-presenting cells (APCs) and isolated a cDNA clone that allowed expression of the appropriate peptide/Kb MHC complex in APC.

lacZ

peptide/Kb MHC complex


Input: This results in a decreased secretion of immunoglobulin A, and, consequently, a decreased resistance against infections.

immunoglobulin A


Input: A previously developed kinetic model was used to identify major chemical reaction pathways involving PAH in the afterburner.


Input: Regulation of the p21-activated kinase (PAK) by a human Gbeta-like WD-repeat protein, hPIP1.

p21-activated kinase

PAK

human Gbeta-like


Input: Activation of HIV-1 requires the binding of host cell transcription factors to cis elements in the proviral long terminal repeat (LTR).


Input: Based on the ratios of the areas under the concentration-time curves in CSF and serum, the overall penetration of rifampicin into CSF was 0. 13-0. 42 (median = 0. 22).


Input: Adaptability of Nippostrongylus brasiliensis (Travassos, 1914) to lead contamination


Input: In early midgestation embryos it is expressed in telencephalic, diencephalic and mesencephalic regions but from day 11. 75 of gestation its expression disappears from dorsal telencephalon and is confined to diencephalic and mesencephalic regions.


Input: A child presumed to have the 21-hydroxylase deficiency form of congenital adrenal hyperplasia was studied extensively as an infant.


Input: The size and the predicted N-terminal sequence of the mouse protein were confirmed experimentally.


Input: It was found that Nopp140 binds primarily to the CK2 regulatory subunit, beta.

CK2 regulatory subunit, beta


Input: Further, more recent communications suggest that liver disease led to a differential alteration of the cytochrome P-450s with regard to protein content and activity.

cytochrome P-450s


Input: A constructed phylogenetic tree suggests that the UbcP1 protein may represent a member of a distinct subfamily of E2s.

UbcP1 protein


Input: Isolates of B. burgdorferi from humans, rodents, and I. dammini are usually indistinguishable, but strains of B. burgdorferi with different major proteins have been identified.


Input: Alignment of the rat and human WIN cDNAs and their comparison with mouse genomic sequence revealed that the WIN DNA binding domain is encoded by four exons, two of which (exons 4 and 6) are alternatively spliced to generate at least three classes of mRNA transcripts.

rat and human WIN cDNAs

WIN DNA binding domain


Input: 25 patients received 20 mgs of hyoscine N-butyl bromide and the rest 5 mgs propinoxate, i. v. plus diazepam.


Input: The activity of plasminogen activator has been measured in tissue sections with the aid of a modified Todd technique.

plasminogen activator


Input: These sequences were further tested for the presence of an enhancer element, by their ability to activate a fusion reporter gene consisting of the CAT gene linked to the gamma-globin gene promoter, in erythroid (K562) and non-erythroid (HeLa) cells.

CAT gene

gamma-globin gene promoter


Input: Here we demonstrate that CD40 or IgM receptor stimulation of primary B cells results in transactivation of this enhancer.

IgM receptor


Input: DESIGN, SETTING AND SUBJECTS: The analysis is based on data collected in the first two rounds of the nationally representative Ghana Living Standards Survey, held in 1987/88 (GLSS-I) and 1988/89 (GLSS-II), with both surveys covering approximately 3000 households.


Input: Genetic and physiological experiments suggest a close relationship between cdc27 + and the cdc2 + gene, a key regulator of mitosis in yeast and also in higher eukaryotic cells.

cdc27 +

cdc2 + gene


Input: Association of Syk protein tyrosine kinase (PTK) with LMP2A occurs at the two tyrosines of the LMP2A immunoreceptor tyrosine-based activation motif, and it is hypothesized that Lyn PTK associates with the YEEA amino acid motif at LMP2A tyrosine 112 (Y112).

Syk protein tyrosine kinase

PTK

LMP2A immunoreceptor

Lyn PTK


Input: Theoretical mechanisms of hyperuricemia.


Input: As a result, relative biological effects (RBE) of 2. 3-2. 7 was obtained from the straight line that was given by modifying by the method of least squares the curves of the frequency of anomalous fetuses in total implants and survived embryos irradiated from 20 to 120 rad by Cf-252 and from 80 to 220 rad by Co-60 on day 8 of pregnancy.


Input: Moclobemide is a well-tolerated alternative antidepressant, but there is a need for prospective controlled trials to evaluate its long-term efficacy.


Input: In a pilot study in which two dogs were given parenteral rifampin before and after operation and grafts were preclotted with blood that contained rifampin, it was suggested that there was a slight increase in inhibition at 24 hours (93%).


Input: Northern blot analyses were used to examine the regulated expression of the cys-14 + gene.

cys-14 + gene


Input: The mouse tapasin gene was mapped about 70 kilobases from H2-K at the centromeric end of the mouse MHC.

mouse tapasin gene

mouse MHC


Input: Conversion of glucose phosphate-14C to glucose-14C in passage through human brain in vivo.


Input: New, selective catechol-O-methyltransferase inhibitors as therapeutic agents in Parkinson' s disease.

catechol-O-methyltransferase


Input: The sequence of the gene upstream to the cap site contains characteristic RNA polymerase II promoter-binding sites: a putative TATA box at position-29 and a Sp 1 binding site (GGGGCGGAGA) at position-48.

RNA polymerase II promoter-binding sites

Sp 1 binding site


Input: We propose that, while Y. lipolytica CEN DNA is essential for plasmid maintenance, this function can be supplied by several sub-fragments which, together, form the active chromosomal centromere.


Input: These three groups were further examined with regard to the modulation of discharge rate i) during motor activity in W, ii) at the transitional phase from SS to paradoxical sleep (PS), iii) during rapid eye movements (REMs) in PS, and iv) following electrical stimulation of the midbrain reticular formation (MRF).


Input: Benzyl alcohol administration in neonates.


Input: Id-1H and Id-2H seem to be human homologues of mouse Id-1 and Id-2, respectively, and have potential to encode 154 and 135 amino acid proteins.

mouse Id-1


Input: Normal dogs were exposed to either 10, 15, or 30 Gy of X rays to a single hemisphere and the gross and histopathologic changes were evaluated qualitatively.


Input: The characterization of fly receptors with features similar to mammalian glycoprotein hormone receptors allows a better understanding of the evolution of this unique group of GPCRs and future elucidation of their ligand signaling mechanisms.

mammalian glycoprotein hormone receptors

GPCRs


Input: To study the mechanisms and the signaling pathways involved, IGF-1R promoter reporter constructs were transiently transfected in CHO-AT1 cells that overexpress angiotensin AT1 receptors.

IGF-1R promoter reporter constructs

angiotensin AT1 receptors


Input: Importin beta mediates nuclear translocation of Smad 3.

Importin beta

Smad 3


Input: In summary, the only treatment-related effect noted in this study was hydrocarbon nephropathy in male rats, which is not considered relevant for human health.


Input: Characterization of an unusual tRNA-like sequence found inserted in a Neurospora retroplasmid.


Input: Gel shift analysis of protein binding from nuclear extracts to these caveolin promoter DNA sequences, together with DNase I footprinting, confirmed nucleoprotein binding to the SRE-like elements as part of the transcriptional response to LDL-FC.

caveolin promoter DNA sequences

DNase I

LDL-FC


Input: The Ca2 + concentration in rats serum after intragastrically fenarimol administration (doses 1/40, 1/20 and 1/10 LD50) during 5 days was investigated.


Input: Furthermore, deletion of two potential Ste11 recognition sites in the fus1 promoter region abolished transcription, and expression could be restored when we inserted a different Ste11 site from the mat1-P promoter.

Ste11 recognition sites

fus1 promoter

Ste11 site

mat1-P promoter


Input: J., & Olefsky, J.


Input: Early attempts for modifying growth functions to annual variations dating back up to 2 decades are recalled together with examples for their application showing rather different degrees of approximation.


Input: PRIP contains two LXXLL signature motifs.

PRIP


Input: BPN can be experimentally produced by intratracheal inoculation of microorganisms in high concentrations and ventilator-associated BPN by ventilating baboons with oleic-acid lung injury.


Input: Coexpression of a dominant negative c-jun antagonized the ras-dependent stimulation of the 92-kDa gelatinase B promoter-driven CAT reporter.

dominant negative c-jun

ras

92-kDa gelatinase B

CAT reporter


Input: However, the safety of design 4 was assured as long as all patients received three courses of chemotherapy, which is unusual in phase I studies in Japan.


Input: The plants were then brought to our Houston laboratory where they were measured and analyzed for lignin and protein content and for phenylalanine ammonia-lyase (PAL) and peroxidase activities.

phenylalanine ammonia-lyase

PAL

peroxidase


Input: The nucleotide sequence of a PCR-amplified SMT3A genomic DNA fragment was found to be identical to that of SMT3A cDNA, indicating the absence of intron (s) in its protein coding region.

SMT3A cDNA


Input: Activation of tyrosine kinase-containing receptors, heterotrimeric G proteins, and protein kinase C enhanced the activities of both MEK isoforms in 293 and PC12 cells.

tyrosine kinase-containing receptors

heterotrimeric G proteins

protein kinase C

MEK isoforms


Input: CONCLUSIONS: Transpulmonary stable air microbubbles bound to a galactose carrier represent a useful and safe contrast agent in case of an insufficient native signal in transcranial Doppler investigation.


Input: DP-1 and DP-2 encode maternally stored transcripts that are expressed during early development.


Input: Human recombinant erythropoietin (r-HuEPO, EprexR) was administered to 8 children with chronic renal failure and high transfusion requirement.

Human recombinant erythropoietin

r-HuEPO

EprexR


Input: Specifically, we engineered two chimeras in which the N-terminal lobe of the SH1 domain of c-Abl was swapped with that of v-Src.

SH1 domain

c-Abl

v-Src


Input: Indications for therapy using MAO inhibitors

MAO


Input: Although IL-6 can activate ERK-1 in HepG2 cells, STAT3 transactivation and Ser (727) phosphorylation were not reduced by using the MAP kinase/ERK kinase (MEK) inhibitor PD98059 or by overexpression of dominant-negative Raf.

MAP kinase

ERK kinase

MEK

Raf


Input: Mean disposition constants (+/-SD) were obtained from individualized fits (V1: 0. 398 +/-0. 336 LITER/KG, Vdarea: 2. 53 +/-0. 72 liter/kg, alpha: 0. 316 +/-0. 294 min-1, beta: 0. 00204 +/-0. 00262 min-1, k2: 0. 0305 +/-0. 0101 min-1).


Input: Clinical trials bring informations for pharmacology and epidemiology.


Input: We have compared the ability of GST-Bem3 to serve as a GAP for Cdc42Hs relative to other members of the rho-GAP subfamily and found the following order of potency: human platelet Cdc42Hs GAP > p190 > Bem3 > break point cluster region protein, whereas p85, like Bem2, shows no GAP activity or any ability to bind to the GTP-bound form of Cdc42Hs.

GST

GAP

rho

GAP

human platelet Cdc42Hs GAP

break point cluster region protein

GAP


Input: Through effective use of laboratory testing database, it will be possible to shift away our vague management of pre-analytic phase of quality control so far to its established system based on objective evaluation.


Input: Nonlinearities in cochlear hydrodynamics.


Input: The peptides are generated in the cytosol, then translocated across the membrane of the endoplasmic reticulum by the transporter associated with antigen processing (TAP).

transporter associated with antigen processing

TAP


Input: An in vitro' glass stomach' (containing various volumes of hydrochloric acid [HCl] and ammonium chloride [NH4Cl]) was used to evaluate the means of increasing' gastric' pH to that of the NH4 +--> NH3 transition that occurs significantly at pH 9. 24.


Input: Moreover, a hybrid protein composed of a PvALF activation domain and the DNA binding and dimerization domain of ROM2 activated gene expression, indicating that ROM2 recognizes the DLEC2 enhancer in vivo; consequently, ROM2 functions as a DNA binding site-dependent repressor.

PvALF activation domain

DLEC2 enhancer


Input: Northern analyses further confirm that the expression of endogenous alpha-ENaC gene in salivary Pa-4 cells is suppressed by an ectopic HMGI-C overexpression.

alpha-ENaC gene

HMGI-C


Input: Finally, we demonstrated that although the DNA-binding domain of c-myb is required for both the differentiation block and the shift in cell cycle after PMA treatment, phosphorylation by casein kinase II and mitogen-activated protein kinase at positions 11 and 12 or 532 of c-myb, respectively, are not.

c-myb

casein kinase II

mitogen-activated protein kinase

c-myb


Input: We found that RXR and VDR transactivated selectively from VDRE-linked templates exclusively as a heterodimeric complex, since neither receptor alone enhanced transcription in vitro.

RXR

VDR


Input: We found a significant increase of thromboxane as evidenced by the major urinary metabolite 2, 3-dinorthromboxane B2 in the oestrogen group as compared to the orchidectomy group.


Input: Assays of APRE-luciferase reporter plasmids transfected into HepG2 cells show that a mutated APRE that binds only BPi functions as an IL-1 alpha inducible enhancer, whereas a mutated APRE that binds only BPc does not.

luciferase

BPi

IL-1 alpha

BPc


Input: Compared with controls, patients in the unmedicated state had low smooth pursuit gain, had a higher rate of corrective catch-up saccades, and tended to spend less time engaged in the tracking task.


Input: Epstein-Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP-J kappa, the homologue of Drosophila Suppressor of Hairless.

Epstein-Barr virus nuclear antigen 2

recombination signal binding protein RBP-J kappa

Drosophila Suppressor of Hairless


Input: A. thaliana cystathionine beta-lyase exhibits 22% sequence identity with the E. coli corresponding enzyme and contains a 70 amino acid N-terminal additional sequence compared with the bacterial protein.

A. thaliana cystathionine beta-lyase


Input: The three-dimensional structure of the E. coli CR domain indicates that this sequence conservation is likely to result in a conserved structural motif.


Input: Co-expression of PLD1 in COS-7 cells with the two recombinant CK2 subunits, alpha or beta, suggests that the association of PLD1 with the kinase is through the beta subunit.

recombinant CK2 subunits


Input: Despite this dependency, however, a B. japonicum fixK mutant did not have the phenotypic characteristics of B. japonicum fixL and fixJ mutants: the fixK mutant was neither Fix-in symbiosis with soybean plants nor defective in anaerobic respiration with nitrate as the terminal electron acceptor.

B. japonicum fixK mutant

B. japonicum fixL

fixJ mutants

fixK mutant


Input: The predicted amino acid sequence of Pst1p possessed high sequence homology with the Sin3 family of proteins, known for their interaction with histone deacetylases.

Sin3 family

histone deacetylases


Input: This selective squelching activity suggests that GRIM can interact with an essential component of the RNA polymerase II transcription machinery.

GRIM

RNA polymerase II


Input: A third group (n = 10) was assigned to receive the canalith repositioning maneuver without mastoid vibration.


Input: With the help of partially overlapping parenchymatous sutures, different renal segments were devitalized.


Input: The S. typhimurium aspartyl/asparaginyl beta-hydroxylase homologue (designated lpxO) was cloned into pBluescriptSK and expressed in Escherichia coli K-12, which does not contain lpxO.

S. typhimurium aspartyl/asparaginyl beta-hydroxylase homologue

lpxO

lpxO


Input: Cardiac NE spillover was higher (P <. 05) at baseline in the patient group than in healthy subjects, whereas renal and whole-body NE spillovers were similar between the study groups.


Input: Translation of mok is tightly regulated by Sok RNA, and Sok RNA thus regulates hok translation indirectly through mok.

mok

Sok RNA

Sok RNA

hok

mok


Input: In this work, we determined the sequences of eight VirF-binding sites from four different genes, by DNase I or hydroxyl radical footprinting.

VirF-binding sites

DNase I


Input: Treatment with ACE inhibitors after acute myocardial infarction

ACE


Input: One-hour O3, NO2, and SO2 personal exposures were measured using samplers developed in our laboratory, while short-term PM2. 5, CO, and VOCs exposures were measured using currently available monitors.


Input: Recombinant MsERK1 (rMsERK1), when overexpressed in Escherichia coli, is recognized by antibodies raised against MAP kinases from rat, Xenopus, and sea star and by anti-phosphotyrosine antibodies.

Recombinant MsERK1

MAP kinases from rat, Xenopus, and sea star

anti-phosphotyrosine antibodies


Input: However, UV resistance is only minimally restored, and mutant cells remain sensitive to gamma radiation.


Input: The melanoma growth stimulatory activity/growth-regulated protein, CXCL1, is constitutively expressed at high levels during inflammation and progression of melanocytes into malignant melanoma.

melanoma growth stimulatory activity/growth-regulated protein


Input: The activated glucocorticoid receptor forms a complex with Stat5 and enhances Stat5-mediated transcriptional induction.

glucocorticoid receptor


Input: A simple procedure for accurate quantitation of factor VIII inhibitors.

factor VIII


Input: Diagnostic importance of determining leucine aminotransferase activity in acute pancreatitis

leucine aminotransferase


Input: In contrast, T229E-p70s6k migrated more slowly in SDS-polyacrylamide gels, but demonstrated partial kinase activity (approximately 20% compared with the wild type).


Input: Transcription factor IIIC (TFIIIC) is required for the assembly of a preinitiation complex on 5S RNA, tRNA, and adenovirus VA RNA genes and contains two separable components, TFIIIC1 and TFIIIC2.

Transcription factor IIIC

TFIIIC

5S RNA

adenovirus VA


Input: Synchronous multicentric giant cell tumour: a case report with review of literature.


Input: Lysates of COS cells transfected with modified hGrzB cDNA were able to hydrolyze tert-butyloxycarbonyl-Ala-Ala-Asp-thiobenzyl ester (Boc-Ala-Ala-Asp-SBzl), whereas lysates transfected with unmodified hGrzB cDNA were inactive.

modified hGrzB cDNA

unmodified hGrzB cDNA


Input: Mutant M proteins were tested for their ability to complement growth of the temperature-sensitive M protein mutant virus tsO23 at the nonpermissive temperature.

Mutant M proteins

M protein mutant


Input: The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions.

POU


Input: It competes with the calcium ion which brings about inhibition of myosine kinase, and therefore a drop in phosphorylated myosine.

myosine kinase


Input: It appears to be useful in untreated patients with stage I or II NHL but no definite radiographic abnormalities, or with abnormal radiographs but no extrathoracic spread, and in treated patients with questionable radiographs.


Input: We conclude that LGCS is successful in treating esophageal varices in the setting of hyperdynamic portal circulation with acceptable liver function.


Input: 3) The progress of fibrinolysis was observed by serial collection of middle ear fluid in the same side ear of 5 cases out of 17 cases having much activity for fibrin degradation, and lowering of fibrinolytic activity was revealed in 4 out of these 5 cases as the result.

fibrinolysis


Input: In lyzozyme activity there was periodicity in three groups but not in the youngest foals.

lyzozyme


Input: Alternative roles of these DNA motifs as activators of early mRNA transcription and as an initiator element for late mRNA transcription help explain how polyomavirus gene expression is regulated during lytic growth and provides a model for cellular transcription during development.


Input: The median levels of t-PA Ag and PAI in plasma were respectively 10. 7 ng/ml (interquartile range 8. 6 ng/ml) and 15. 7 IU/ml (interquartile range 12. 2 IU/ml).

t-PA Ag

PAI


Input: The Mer1 protein contains the KH motif found in some RNA-binding proteins, and RNA gel mobility shift assays demonstrate that Mer1 binds specifically to MER2 RNA.

Mer1 protein

MER2 RNA


Input: Collectively, these studies suggest that the major EGF-stimulated mitotic growth pathways may not be absolutely linked to the stat91 signaling pathways and that such transcription complexes are more complex than previously reported.

EGF


Input: A procaryotic regulatory factor with a histone H1-like carboxy-terminal domain: clonal variation of repeats within algP, a gene involved in regulation of mucoidy in Pseudomonas aeruginosa.

histone H1-like carboxy-terminal domain

algP


Input: Innervation of reticular papillae in sheep and goats.


Input: The monkeys had been administered a common lead isotope " mix " at the rate of about 1300 micrograms Pb/kg body wt/day from age 10 months until the start of the study.


Input: Previous studies showed that a palindromic sequence located at-159 base pairs is essential for induction of cutinase gene in Fusarium solani f. sp. pisi (Nectria haematococca mating type VI) by the hydroxy fatty acids from plant cutin and that a 50-kDa nuclear protein binds to a promoter that contains this element.

cutinase gene


Input: In cells co-expressing high levels of the p38 (MAPK) kinase (MKK3) together with the p38 (MAPK), a significant inhibition of mitogen-induced cyclin D1 expression was observed.

MAPK

MAPK

cyclin D1


Input: Pig uPA promoter-CAT constructs were more active than mouse constructs in this assay.

uPA

CAT


Input: Thermal changes of the bovine uterus following administration of estradiol-17beta.


Input: Elements regulating cell-and stage-specific expression of the C. elegans MyoD family homolog hlh-1.

MyoD


Input: Restriction analysis of the isolated genomic clones indicated that the endogenous sequences abutting the 3' ends of the 94-A and 94-K transgenes are separated by less than 20 kb, providing strong support for the single integration model.


Input: The sensitivity for ergometry and treadmill testing was 75 and 62% respectively.


Input: All these abnormalities returned to normal after removal of the tumor.


Input: The STS sequence WI-14920 is in fact derived from the 3'-untranslated region of the human PUNC gene.

STS sequence WI-14920

human PUNC gene


Input: Four antifungal agents were compared: amphotericin B, flucytosine, miconazole, and ketoconazole.


Input: Phylogenetic analysis of yeast, invertebrate, and multiple mammalian isoforms of SNF4 shows that the gene duplication likely occurred early in the metazoan lineage, as the protein products of the different loci are relatively divergent.


Input: Blood samples (30 ml) were collected via an indwelling arm catheter at rest, and at minutes 13 and 28 of exercise for determinations of plasma EPI, serum free fatty acid (FFA), serum glycerol (GLY), blood glucose (GLU), and blood lactate (LA) concentrations.


Input: The NF-kappa B precursor p100 (lyt-10, p97, p98) generates after proteolytic processing a 52 kDa subunit, which can bind to kappa B-motifs.

NF-kappa B

kappa B-motifs


Input: The delta mean VAF and delta mean SABP indicated varied mean values of VAF and SABP, respectively.


Input: Gel mobility shift analyses reveal that FRTL-5 thyroid cell nuclear extracts form a specific protein/DNA complex with this region, which is prevented by the TTF-1 binding element from the TG promoter; FRT and BRL cell nuclear extracts do not have TTF-1 and do not form this complex.

TTF-1 binding element

TG promoter


Input: The rice gene consists of four exons.


Input: Thallium-201 scintigraphy after dipyridamole infusion with low level exercise.


Input: Dominant-negative upf1 mutations were isolated following in vitro mutagenesis of a plasmid containing the UPF1 gene.

UPF1 gene


Input: One of the ORFs in the Methanococcus jannaschii genome possesses high similarity to the M. aeolicus ilvB, indicating that it is an authentic AHAS.

M. aeolicus ilvB

AHAS


Input: It differed from cued recall only in the instructions, which directed subjects away from the memory aspects of the test and asked them to complete each three-letter cue with the first word that came to mind.


Input: Such saturation often occurs for several recording sweeps after large amplitude signals such as eye blinks are rejected.


Input: To define the molecular mechanism regulating FGFR-1 gene expression in proliferating myoblasts and post-mitotic muscle fibers, we have isolated and partially characterized the avian FGFR-1 gene promoter.

FGFR-1 gene

FGFR-1 gene


Input: Samarium-153 for intravascular irradiation therapy with liquid-filled balloons to prevent restenosis: acute and long-term results in a hypercholesterolemic rabbit restenosis model.


Input: This element was required for both basal and activated expression and almost certainly functions as a TATA-binding protein interaction site.

TATA-binding protein


Input: This report establishes that the effect of homozygous sickle cell disease on growth patterns in childhood is apparent before the age of 6 years.


Input: But it is possible that the two hemispheres differ in the manner in which they make use of semantic structures: the left hemisphere in a selective manner, appropriate for the solution of a specific task, and the right hemisphere in a more diffuse and global manner.


Input: The results reveal preferences for particular initiating nucleotides (ATP > or = GTP > UTP > > CTP) and for starting positions downstream of the Pribnow box (7 > > 6 and 8 > 9 > 10).


Input: We determined that Hop (T42) contains a glutamic acid-to-lysine substitution at amino acid residue 695 (E695K).

Hop (T42)


Input: Androgen ablation--50 years later.


Input: It is suggested that on presentation of tail tip necrosis in kittens a diagnosis of neonatal isoerythrolysis or isoagglutination should be considered.


Input: Men and women entering psychotherapy more often had negative Wish elements than others.


Input: This clone will be useful for identifying the genetic determinants of FIV-Oma' s biological activities.


Input: Serum prolactin and oestradiol levels at different stages of puberty.

Serum prolactin


Input: The sequence of three of them revealed pure CAG stretches.


Input: Total body BMD (r = 0. 30; P = 0. 02) and femoral neck BMD (r = 0. 39; P = 0. 002) were positively correlated with weight-bearing activity but not with non-weight-bearing activity.


Input: PCC 6803 mutant impaired in cytochrome c maturation.

cytochrome c


Input: Ureases were purified from the recombinant cells and shown to be identical to control enzyme when analyzed by gel filtration chromatography and sodium dodecyl sulfate-polyacrylamide gel electrophoresis; however, in every case the activity levels correlated to nickel contents as analyzed by atomic absorption analysis.

Ureases


Input: Sequence analysis of the catfish JH-CH intron suggests that several sequences are present which appear similar to important transcriptional regulatory elements found within JH-CH introns of higher vertebrates.

JH

CH

JH

CH


Input: Seroconversion after hepatitis B vaccination.


Input: On day 1 at 3500 m, RI showed a significant fall in body weight (BW) with respect to SL but AI maintained it.


Input: Expression of CBP/p300 potentiated HS2-mediated transactivation.

CBP


Input: The perforated splint gives superior results by virtue of the fact that it does not require to be removed for purposes of hygiene and can thus produce a satisfactory result even in those patients who fail to grasp the technique of removal and replacement of the splint.


Input: Using lasers in diabetic wound healing.


Input: Protein metabolism disorders in burns


Input: In contrast, MAPK activation stimulated by the Gq-coupled alpha 1B AR or M1 muscarinic cholinergic receptor is unaffected by expression of beta ARKct or RasN17 expression or by PTK inhibitors, but is blocked by expression of N delta Raf or by PKC depletion.

MAPK

Gq

M1 muscarinic cholinergic receptor

beta ARKct

PTK

N delta Raf

PKC


Input: RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2.


Input: Extra dose due to extravehicular activity during the NASA4 mission measured by an on-board TLD system.


Input: Preface and acknowledgements.


Input: G-CSF (10 microg/kg) was started on day + 1 and all patients engrafted within a median day number of 12 (range, 10-22) until leukocytes > 1. 0 x 10 (9)/l and a median day number of 56 (range, 10-180) until platelets > 20. 0 x 10 (9)/l (ie platelet transfusion independence).

G-CSF


Input: The present study indicates that the high-dose 5-fluorouracil regimen shows weak activity in advanced pancreatic cancer which seems comparable to gemcitabine.


Input: At D28, 149 of 386 patients (49%) had had episodes of automatic mode switch prompted by atrial arrhythmias.


Input: Thus, the rates of a-factor receptor endocytosis and consequent vacuolar turnover depend on the available level of ubiquitin in the cell.

a-factor receptor

ubiquitin


Input: Early diagnosis and early surgical division of the biliary tract and pancreatic duct is recommended for children with AAPBD.


Input: This approach allowed examination of baseline factors as well as the effect of change in mileage, the occurrence of a musculoskeletal problem, or the occurrence of another health problem on the rate of dropout.


Input: Increased gliadin antibody levels were found more frequently in patients with subtotal villous atrophy (9 out of 17 patients, or 53%; p less than 0. 05) than in patients with partial villous atrophy (2 out of 13 patients, or 15%) or normal villous appearance (2 out of 10 patients, or 20%).

gliadin antibody


Input: The effects of cefazolin, given into the III cerebral ventricle at different doses were studied on GABA content, GAD and GABA-T in the brain-stem of young chickens (Gallus domesticus).


Input: This sequence was sufficient to confer p53-dependent activation to a heterologous promoter and p53 was capable of binding to this sequence as assessed by gel shift analysis.


Input: CAT assays demonstrated that overexpression of RXRalpha conferred the best RA response, consistent with our previous observation that 9-cis-RA is more potent than all-trans-RA for inducing the expression of the AFP gene.

CAT

RXRalpha

AFP gene


Input: In addition, the results suggest that N region diversity at V (D) J junctions within rearranged immunoglobulin and T cell receptor gene loci can only be introduced after the generation of RAG-catalyzed DNA double-strand breaks, i. e. during the DNA end joining phase of the V (D) J recombination reaction.

V

D

J

immunoglobulin

T cell receptor gene loci

RAG

V

D

J


Input: The pra2 gene encodes a pea (Pisum sativum) small GTPase belonging to the YPT/rab family, and its expression is down-regulated by light, mediated by phytochrome.

pra2 gene

pea (Pisum sativum) small GTPase

YPT

rab

phytochrome


Input: To directly address this issue, we used a tetracycline-regulated system in human U2OS osteosarcoma cells and thus found that BCL6 mediates growth suppression associated with impaired S phase progression and apoptosis.


Input: Changes in water and electrolyte content of the brain and edema formation after acute, drug-induced hypertension were studied in albino rabbits.


Input: The amino-terminal gag-encoded region of P140gag-fps contains a phosphotyrosine residue in addition to normal gag phosphorylation sites.

amino-terminal gag-encoded region

fps

gag


Input: To explore the effect of persistent cardiomegaly on cardiovascular function, groups of newborn rats inhaled up to 500 ppm CO for 33 days, after which development continued in ambient air.


Input: The subjects' lungs were ventilated with N2O in O2 (FIO2 0. 3) to the end-tidal CO2 present before anesthesia, and then CBF was measured using intravenous 133Xe and ten scintillation counters, five over each cerebral hemisphere.


Input: Cutaneous melanoma and bilateral retinoblastoma.


Input: This complex was eliminated by mutation of either half-site, and it was supershifted by antibodies against chicken ovalbumin upstream promoter-transcription factor (COUP-TF).

chicken ovalbumin upstream promoter-transcription factor

COUP-TF


Input: Polymorphisms in the CCR5 genes of African green monkeys and mice implicate specific amino acids in infections by simian and human immunodeficiency viruses.

CCR5 genes


Input: The transcription start site was localized 224 bp upstream the ATG codon by RNase protection and primer extension mapping.

RNase


Input: Statistical aspects of the relation of the radioprotective action of mercaptoethylamine derivatives and analogs to their electron parameters


Input: Six patients (24%) developed sepsis and only one survived.


Input: The material then was cut with a diamond saw into sheets of 8 x 10 x 3 mm, and the upper surface was polished by colloidal SiO2 and/or covered with a carbon-titanium (C: Ti) layer (3. 3 microm) using the plasma-enhanced physical vapor deposition method.


Input: We present here a statistical technique we developed to identify the sequence elements that may be responsible for this cell cycle regulation.


Input: Diabetic osteopenia, a known chronic complication of diabetes, has been demonstrated with alterations in the calcium-vitamin D endocrine system.


Input: From the comparison of the nod box sequences of (brady) rhizobia with a more divergent nod box from Azorhizobium caulinodans, we now propose a modular build-up of the nod box with the sequence A-T-C-N9-G-A-T as the binding target of the NodD protein (the NodD box).

nod box sequences

nod box

nod box

NodD protein

NodD box


Input: This dip also occurred during prednisone and vitamin D treatment, but did not occur when calcium was added to prednisone, although the baseline value was lower at the start of combined treatment with prednisone and calcium.


Input: Highly conserved regions called src homology 2 and 3 (SH2 and SH3), comprising amino acid residues 88 to 250, are believed to modulate the protein-tyrosine kinase activity present in the carboxy-terminal halves of the src proteins.

src homology 2

protein-tyrosine kinase

src proteins


Input: The addition of novel techniques, such as histopathologic ultrastaging, immunohistochemistry staining, and reverse transcriptase polymerase chain reaction assays, will help increase the accuracy and rate of detection of disease.

reverse transcriptase


Input: Acanthamoeba myosin I heavy chain kinase (MIHCK) phosphorylates the heavy chains of amoeba myosins I, increasing their actin-activated ATPase activities.

Acanthamoeba myosin I heavy chain kinase

MIHCK

amoeba myosins I

actin

ATPase


Input: Two different genes (polA and polB) encoding family B DNA polymerases were cloned from the organism by PCR using degenerated primers based on the two conserved motifs (motif A and B).

polA

polB

family B DNA polymerases


Input: In this reconstituted system, RNAP IIA, but not RNAP IIB, can transcribe from the DHFR promoter.

RNAP IIA

RNAP IIB

DHFR promoter


Input: Furthermore, the data suggest an immunological non-responsiveness to enterotoxin A in a considerable portion of the patients.

enterotoxin A


Input: The polypeptide encoded by the cDNA contained 450 amino acids with a calculated M (r) of 52, 057, and showed significant homology with human and mouse CAD (22% identity).

mouse CAD


Input: Focal or regional 8-to 20-Hz low-voltage epileptiform paroxysms in either hippocampus (10 patients), amygdala (1 patient), or both (1 patient) preceded initial motionless staring.


Input: Cytokine-mediated I kappa B alpha reappearance was completely blocked by the protein synthesis inhibitor cycloheximide.

I kappa B alpha


Input: In addition, the authors found one an3 allele (an3-W138A) in which a dTph1 element had inserted 30 bp upstream the translation start, without inactivating the gene.

an3 allele

dTph1 element


Input: The right cornea of rats was cauterized by drops of 1. 5 N HC1 over 30 s; the left one served as a control.


Input: The difference between the effects of the two dose levels of Z.


Input: The purpose of this presentation is to review the current state of knowledge regarding 5, 8, 11, 14-eicosatetraynoic acid (ETYA, Ro 3-1428) and its effects on lipid metabolism.


Input: Pathophysiologic mechanisms underlying spatial disorientation in patients with Alzheimer' s disease.


Input: Secretion of cuticle over and between the domed apical surfaces of these cells leads to a honeycomb-like structure and gives the superficial wart-like phenotype of mitotic clones on the adult.


Input: The sequences of two previously known tail genes, R and S, of the temperate bacteriophage P2 and the sequence of an additional open reading frame (orf-30) located between S and V, were determined.

tail genes

R

S

S

V


Input: NGF also induced a synthetic promoter with repeated Sp1 sites linked to a core promoter, and a plasmid regulated by a chimeric transactivator in which the Gal4 DNA binding domain is fused to the Sp1 transactivation domain, indicating that this transactivation domain is regulated by NGF.

NGF

Sp1 sites

Gal4 DNA binding domain

Sp1 transactivation domain

NGF


Input: Nuclear transcription assays confirmed that cys-3 + was under sulfur-regulated transcriptional control and that cys-3 + transcription was constitutive in sulfur controller (scon)-negative regulator mutants.

cys-3 +

cys-3 +

sulfur controller

scon


Input: These results suggest that UvrA is involved in triplet repeat instability in cells.

UvrA


Input: We conclude, therefore, that in the absence of E1A, E4orf4 is sufficient by itself to trigger a p53-independent apoptosis pathway that may operate independently of the known zVAD-inhibitable caspases, and that may involve an as yet uncharacterized mechanism.

caspases


Input: CONCLUSIONS: The system developed in this study can be used as a method to detect air-trapping during TGI.


Input: The nucleotide sequence of the gene encoding this product was determined and the amino acid sequence deduced.


Input: After a shift to 37 degrees C, the mutant Rat7-1p/Nup159-1p is lost from the nuclear rim of rat7-1 cells and NPCs, which are clustered together in these cells grown under permissive conditions become substantially less clustered.


Input: Evidence for Gcr1p/Gcr2p interaction has been presented earlier and is now supported by the isolation of mutations in Gcr1p suppressing gcr2, as assessed by growth and enzyme assay.


Input: Renal function was evaluated in a group of 24 patients (21 men and 3 women, mean age 47 years) who had survived the malignant phase of hypertension during the period of 1969-1979.


Input: Mammalian ribonucleotide reductase shows S-phase specific expression and consists of two non-identical subunits, proteins R1 (large subunit) and R2 (small subunit).

ribonucleotide reductase

proteins R1


Input: Azoospermia was graded in the following way: adequate spermatozoa (A1), low, scanty or rare spermatozoa (A2), spermatid arrest (B1), spermatocyte arrest (B2), Sertoli cell-only pattern (C) and sclerosis (D).


Input: This paper describes a course of therapy with an agoraphobic female patient.


Input: Plasmids bearing the P. stipitis URA3 gene and ARS2 element produced more than 30, 000 transformants per micrograms of plasmid DNA.

P. stipitis URA3 gene


Input: The activation of NF-kappaB-dependent reporter gene transcription by E1A was potently suppressed upon coexpression of the E1B 19-kDa protein (19K).

NF-kappaB

E1B 19-kDa protein (19K)


Input: We analyzed the effects of light on tubulin mRNA abundance in Arabidopsis seedlings using RNA gel blot hybridizations and gene-specific probes.

tubulin mRNA


Input: We conclude that transcription of both SCD1 and SCD2 genes is responsive to cellular sterol levels and to the levels of nuclear SREBP/ADD1 and that transcriptional induction requires three spatially conserved cis elements, that bind SREBP and NF-Y.

SCD2 genes

SREBP

SREBP

NF-Y


Input: BACKGROUND: Recent iterative methods for sequence alignment have indicated that the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases.

dynein

AAA class

chaperone-like ATPases


Input: It is suggested that death of S. mansoni cercariae during penetration of mammalian host skin is probably due to exhaustion of their energy reserves.


Input: In particular, lacZ transcripts synthesised this way are highly unstable and yield little beta-galactosidase.

lacZ transcripts

beta-galactosidase


Input: Recent research on lipolysis.


Input: Instead, HBx is shown to activate the cyclin A promoter, induce cyclin A-cyclin-dependent kinase 2 complexes, and promote cycling of growth-arrested cells into G1 through a pathway involving activation of Src tyrosine kinases.

HBx

cyclin A promoter

cyclin A

cyclin-dependent kinase 2

Src tyrosine kinases


Input: Fifty-seven per cent of the primary patients reporting mild symptoms had abnormal levels of leucocytes in their CSF.


Input: The vertebrate transcription factors TCF (T cell factor) and LEF (lymphocyte enhancer binding factor) interact with beta-catenin and are hypothesized to mediate Wingless/Wnt signaling.

vertebrate transcription factors TCF

T cell factor

LEF

lymphocyte enhancer binding factor

beta-catenin

Wingless

Wnt


Input: DESIGN: Activating protein-1 (AP-1) and Tat-induced transcription were assessed using Jun and hybrid Tat/Jun-expression plasmids and reporter gene constructs which contained AP-1 binding sites upstream of the rat prolactin TATAA element or an HIV-1 LTR construct in which AP-1 binding sites replaced the TAR element.

Activating protein-1

Tat

Jun

Tat

Jun

AP-1 binding sites

rat prolactin TATAA element

HIV-1 LTR construct

AP-1 binding sites


Input: The PRP4 protein of Saccharomyces cerevisiae is an essential part of the U4/U6 snRNP, a component of the mRNA splicing apparatus.

PRP4 protein of Saccharomyces cerevisiae


Input: According to the penetration of Ca-45, the microleakage level was scored for each section.


Input: Endothelial purine content.


Input: Binding of transformed Ah receptor complex to a dioxin responsive transcriptional enhancer: evidence for two distinct heteromeric DNA-binding forms.

Ah receptor complex


Input: KatA, AhpCF, heme biosynthesis enzymes, and MrgA are also induced upon entry into stationary phase under conditions of iron and manganese limitation.

KatA

AhpCF

MrgA


Input: Characterization of the chromosome 19 breakpoint region revealed that the transcription factor-encoding USF2 gene is affected.

transcription factor-encoding USF2 gene


Input: Analysis of pseudo VH gene segment recombination products reveals no bias in D gene segment reading frame utilization.

pseudo VH gene segment recombination products

D gene segment


Input: It is dangerous to label such conditions as' inappropriate' secretion of ADH since the maintenance of circulating volume is at least as important a physiological requirement as the defence of tonicity.

ADH


Input: The in vitro activity of KP-103, a novel triazole derivative, against pathogenic fungi that cause dermatomycoses and its therapeutic efficacy against plantar tinea pedis and cutaneous candidiasis in guinea pigs were investigated.


Input: Using a simulated cough machine, we analyzed the effect of adding tensio-active liquids as sol phase simulant on the clearance of gel mucus simulant by cough.


Input: The effects of 4 weeks of cyclosporin A (7 mg/kg per day) (CyA) on the survival of vascularized osteochondral grafts between rat strains [DA (donor) and Lewis (recipient)] and the presence and significance of host immune tolerance and graft antigen modulation after cessation of immunosuppression have been examined.


Input: Insulin binding to the alpha-subunit of its receptor stimulates the receptor tyrosine kinase to phosphorylate the beta-subunit and several endogenous protein substrates, including pp120/HA4, a liver-specific plasma membrane glycoprotein of M (r) 20, 000.

Insulin

receptor tyrosine kinase


Input: The second intron is the smallest of all the introns (116 bp).


Input: Moreover, our recent findings on the Tc52 encoding gene underline the interest of genetic manipulation of T. cruzi, not only making it possible to use more closely an in vitro approach to find out how genes function, but also to obtain' attenuated' strains that could be used in the development of vaccinal strategies.

Tc52 encoding gene


Input: Pretreatment of rats with different dose levels of CCl4 resulted in a prolongation of TMO half-life, and increase of the area under the curve (AUC), and a decrease of clearance, but the apparent volume of distribution (Vd) was not significantly decreased.


Input: Healthy preterm infants of gestational age 26-29 weeks showed a' mature' pattern of permeability at birth, followed by a temporary period of enhanced permeability after 3-4 weeks of life.


Input: The promoter for HMG-CoA synthase contains two binding sites for the sterol regulatory element-binding proteins (SREBPs).

HMG-CoA synthase

sterol regulatory element-binding proteins

SREBPs


Input: Using the same electrical analog, we present an analysis that allows calculation of these parameters, as well as the corner frequency of the network (f1), without need for similar assumptions.


Input: These results suggest that transcription influences aspects of gene conversion after initiation, such as strand invasion and/or mismatch repair (MMR).


Input: In contrast, a similar fusion protein (hGH-LDLR-DAF17, abbreviated HLD) containing a fragment of the serine/threonine-rich domain of the LDL receptor (LDLR) in place of the DAF-derived serine/threonine-rich sequences, does not become GPI anchored.

hGH

LDLR

HLD

LDL receptor

LDLR

DAF-derived serine/threonine-rich sequences


Input: Ocular injuries during general anesthesia.


Input: Of concern is the high, unexplained prevalence of BV among African-American women, who are also at extremely high risk for preterm birth.


Input: The RAG-2 gene encodes a component of the V (D) J recombinase which is essential for the assembly of antigen receptor genes in B and T lymphocytes.

RAG-2 gene

V (D) J recombinase


Input: The LAB in the cecum (mean 9. 4 log CFU/g) increased slightly with increasing abattoir holding time.


Input: Reproduction and maternal response of the rat when thiamine intake is limited.


Input: Activated Ki-Ras suppresses 12-O-tetradecanoylphorbol-13-acetate-induced activation of the c-Jun NH2-terminal kinase pathway in human colon cancer cells.

Activated Ki-Ras

c-Jun NH2-terminal kinase pathway


Input: 11: 5801-5812, 1991) present evidence that the Vps18/Pep3 protein colocalizes with the Vps11/Pep5 protein to the cytosolic face of the vacuolar membrane.


Input: Cell-free extracts of E. coli (fpg mutY) harboring pYSB10 possess an enzymatic activity that cleaves a 34-mer oligonucleotide containing a single 8-oxoG opposite a cytosine (8-OxoG/C).

fpg mutY


Input: The authors discussed their experience in investigating 20 patients with maxillary malignant tumors using routine x-ray studies and MR-tomography, and 13 patients, investigated in the same way plus CT.


Input: Magnification-corrected planimetry of the parapapillary region was performed according to Littmann' s method in 312 unselected eyes with chronic primary open-angle glaucoma and in 125 normal eyes of an age-and refraction-matched control group using optic disk photographs.


Input: Both merR genes consist of a 408 bp ORF coding for 135 amino acids.

merR genes


Input: The 1. 3-kb DNA, when placed upstream of the chloramphenicol acetyltransferase gene, was shown to be functionally active.

chloramphenicol acetyltransferase gene


Input: We show that Fos down regulates several immediate-early genes (c-fos, Egr-1, and Egr-2) after mitogenic stimulation.

Fos

immediate-early genes

c-fos


Input: Polar effects of transposon insertions demonstrated that all of these mRNAs arose from a single promoter region, where transcription initiated 80 bp 5' to nifH.

nifH


Input: Heart disease.


Input: A definitive answer to the question must come from large scale mortality studies of patients in whom the risk/benefit ratio of thrombolysis is not unacceptably high, in whom electrocardiographic criteria of infarction are unequivocal, and in whom treatment can be initiated early after the onset of symptoms with regimens that will induce not only early recanalization, but also sustained patency in infarct-related arteries.


Input: Sonography depicted the true morphology of these cystic lesions more clearly than CT, and the sonographic findings virtually excluded uncomplicated hepatic cyst as a diagnosis.


Input: The formation of tumorlike lesions in the cockroach leucophaea maderae after anal blockage.


Input: Here, we identify the analytical form of the PDF of one such measure, the order parameter in the low temperature phase of the 2D XY model.


Input: The determination of antithrombin III (AT III) and its clinical significance

antithrombin III

AT III


Input: In each of the studied HPV types, the two CDP/Cut binding sites of PSM overlap with the known or presumed binding sites of the replication initiator protein E1.

CDP

Cut

PSM

replication initiator protein E1


Input: With this study, a total of 13 operators for the glp regulon have been characterized.

glp regulon


Input: Located between the 3' trans-spliced leader acceptor site and the translational initiation codon of the GP63 gene is an area of conserved hexanucleotide direct repeats (CTCGCC) which vary in number according to species.

GP63 gene


Input: The aim of this study was to evaluate the impact of the ESRD treatment modality on the quality of life in patients with Type I (insulin-dependent) diabetes mellitus.

insulin


Input: MDA-MB-468 cells were stably transfected with either a plasmid having a CMV promoter-driven rabbit beta-globin gene or plasmids having a CMV promoter-driven chimeric gadd45 5 "-UTR-rabbit beta-globin gene, where the entire gadd45 5 "-UTR (from + 1 to + 298) or a 45 bp subfragment of the gadd45 5 "-UTR (from + 10 to + 55) was positioned at the 5 "-end of the rabbit beta-globin gene.

CMV promoter

rabbit beta-globin gene

CMV promoter

rabbit beta-globin

entire gadd45 5 "-UTR (from + 1 to + 298)

gadd45 5 "-UTR (from + 10 to + 55)

rabbit beta-globin gene


Input: RESULTS: BMK-1 and other 19 contents significantly decreased depolarization parameters Vmax, APA, OS, and MDP, which was similar to that of TTX and different from that of Nim and BaCl2.

TTX


Input: Fourteen samples, seven each of IR64 and IR66 were studied with regard to moisture content, germination test, abnormal seedlings, speed of germination, conductance of leachates, total dehydrogenase activity, total free amino acids, total soluble sugar, fat acidity, gelatinization temperature, gel consistency, amylose content, translucency, and per cent whiteness.


Input: Southern zoo blot analysis indicated that ZNF236 is conserved in the genomes of all mammalian species tested, but not in yeast.


Input: This alternative splice acceptor site is also used by a biologically active provirus with an efficiency of approximately 5% compared with the upstream site.


Input: In addition to loss of digit identity and varying degrees of polydactyly, proximal skeletal elements are severely shortened in Xt; ld double homozygous limbs.

Xt

ld


Input: In turn, production of sufficient amounts of TraR apparently is sensitive to a cellular function requiring RNase D.

TraR

RNase D


Input: In this study, the effect of the antibiotic lasalocid on the rumen anaerobic fungus Neocallimastix frontalis RK 21 was examined.


Input: 4 382 new mothers were examined retrospectively with the enzyme-linked immunosorbent assay (ELISA) for IgG activity to cytomegalovirus (CMV) during pregnancy.

IgG


Input: Promoter, spliced leader, and coding sequence for BICP4, the largest of the immediate-early proteins of bovine herpesvirus 1.

immediate-early proteins of bovine herpesvirus 1


Input: ER beta was less potent than ER alpha in activating E2-stimulated ERELuc activity (4-vs.

ER beta

ER alpha

ERELuc


Input: Our results suggest a dose-dependent activity of lysine vasopressin on the EEG, which might be similar to that observed in animal and man after administration of nicotine.

lysine vasopressin


Input: However, elimination of the kinase activity of DCAMKL1 has no detectable effect on its microtubule polymerization activity.


Input: Sequencing and restriction enzyme analysis demonstrated that this single-copy gene contains 11 exons and spans 9596 base pairs.


Input: Effects of prolonged inhibition of labour pains with Th 1165a and Isoptin on the heart, circulation, organ-and metabolic parameters of the mother


Input: The anaesthetic management of 41 patients who underwent cardiac transplantation during a 40 month period at Clinica Puerta de Hierro is reviewed.


Input: In uraemic patients, similar maximum serum concentrations were found after a single 7. 5 mg/kg iv dose.


Input: In the unit housing of a compact cyclotron and positron emission CT (PET), positron emitting gas such as 15O, 11C, C15O2, C15O etc. is supplied from a cyclotron to a PET room through a transportation pipe with an appropriate shield to reduce positron annihilation radiation.


Input: Although CB-4 isolates were less resistant to chlorine than CB-5 isolates, after 1, 000 min of contact 0. 01% of the input virus was still infectious.


Input: Here we describe the cloning and initial characterization of IPP, a novel human gene that predicts a kelch family protein homologous to the mouse Ipp gene, a previously described kelch family member.

IPP

kelch family protein

mouse Ipp gene

kelch family member


Input: Sequence analysis identifies a ras-associating (RA)-like domain in the N-termini of band 4. 1/JEF domains and in the Grb7/10/14 adapter family.

ras-associating

RA

band 4. 1/JEF domains

Grb7/10/14 adapter family


Input: Sleeping position and sudden infant death syndrome (SIDS): effect of an intervention programme to avoid prone sleeping.


Input: Statistical conservation laws in turbulent transport.


Input: Characterization and targeted disruption of murine Nup50, a p27 (Kip1)-interacting component of the nuclear pore complex. p27 (Kip1) is a member of the Cip-Kip family of cyclin-dependent kinase (Cdk) inhibitors that binds to cyclin-Cdk complexes and inhibits their catalytic activity in response to antiproliferative stimuli. p27 (Kip1) is regulated by several posttranscriptional mechanisms, including subcellular localization.

murine Nup50

Cip

Kip

cyclin-dependent kinase

Cdk

cyclin

Cdk


Input: Further studies are warranted to determine whether these findings are idiosyncratic, coincidental, or a more general phenomenon.


Input: We have identified the gene encoding sigma E using a genetic screen designed to isolate trans-acting mutations that abolish expression from either htrA or rpoHP3, two promoters recognized uniquely by sigma E-containing RNA polymerase.

sigma E

htrA

sigma E

RNA polymerase


Input: METHODOLOGY: A case control study of survivors with gestational age (GA) < 28 weeks or birthweight (BW) < 1000 g using data collected prospectively in our Neonatal Intensive Care Unit database.


Input: Based on these results, it has been concluded that an IPFSA can promote the healing process in the avascular zone of a torn meniscus in rabbits and that systemic vascularity to the synovium or the meniscus is not essential for healing to occur.


Input: Biomass growth monitoring using pressure drop in a cocurrent biofilter


Input: Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the " hot spot " mutant phenotypes.

p53 DNA

ras


Input: The RHO1 gene encodes a homolog of the mammalian RhoA small GTP-binding protein in the yeast Saccharomyces cerevisiae.

RHO1 gene

RhoA small GTP-binding protein


Input: Inspection of X. tropicalis, mouse and human U6 DNA upstream sequences revealed the presence of a TATA box as well as of the proximal and enhancer (octamer motif) elements contained in snRNA genes transcribed by RNA polymerase II.

X. tropicalis, mouse and human U6 DNA upstream sequences

RNA polymerase II


Input: RESULTS: In men, weight/height2 met the criteria for a satisfactory index in that there was a very strong correlation with triceps skinfold, and a negligible correlation with height.


Input: When expressed in thymidine kinase-deficient L cells or 3T3 cells, C/EBPalpha is detected in a protein complex which binds to the E2F binding sites found in the promoters of the genes for E2F-1 and dihydrofolate reductase (DHFR).

thymidine kinase

C/EBPalpha

E2F binding sites

dihydrofolate reductase

DHFR


Input: Phenylalanine and tyrosine levels were higher in those who received Vamin 9 glucose but 55% of infants given Vamin Infant had tyrosine levels below the lower limit of the target range.


Input: Identification of an osteocalcin gene promoter sequence that binds AP1.

osteocalcin gene promoter sequence


Input: CONCLUSIONS: Neurodevelopmental assessment at 1 year is predictive of school performance and outcome in the adolescent period.


Input: Phenotypic responses of additional mutants, including exo1, srs2, rad5, and rdh54 strains, suggest roles in recombinational repair, but not in NHEJ.


Input: Although hSSTR5 displays approximately 75% sequence identity with rat SSTR5, the two receptors display significantly different pharmacological profiles, especially with respect to their binding affinities for the SST analogue SMS 201-995.

rat SSTR5

SST


Input: These findings suggest that IL-1-stimulated, Rho-dependent cytoskeletal reorganization may cluster signaling molecules in specific architectures that are necessary for persistent cell activation in chronic inflammatory disease.

Rho


Input: Deletion mutants of the human CHOP promoter identify a region comprising nucleotides-75 to-104 required for both constitutive and ER-stress-inducible expression.

human CHOP promoter


Input: Anderson Hospital and Tumor Institute at Houston during a 30-year interval (1944 to 1974), with a minimum of ten years of follow-up, we determined that the major prognostic factor of survival was the number of positive nodes.


Input: It is concluded that the atherogenic process includes stimulation of collagen and elastin synthesis.

collagen

elastin


Input: We report nine consecutive cases of ACB, which occurred in five males and four females and were detected in 11, 159 routine spiral CT examinations of the chest, performed between 1994 and 1998.


Input: The absolute CD4 count of patients with de novo IBD was 210-700 cells/ml at the time of IBD.


Input: Four of these fibroblast clones were infected with a retrovirus containing the cDNA encoding myoD and a puromycin selection marker.

cDNA encoding myoD


Input: Sexual adventurism, high-risk behavior, and human immunodeficiency virus-1 seroconversion among the Chicago MACS-CCS cohort, 1984 to 1992.


Input: As already available for the other known mammalian members of this enzyme family, we here define structural and functional features of human lymphoma proprotein convertase (LPC).

human lymphoma proprotein convertase

LPC


Input: This study demonstrates the feasibility and potential usefulness of syngeneic BM Txp in myeloma.


Input: It is important to understand the etiology of HITT because of its devastating clinical consequences.


Input: Results obtained from the tritium test and direct chemical analysis were compared.


Input: Relation between clinical and roentgenological scores and measures of lung function in cystic fibrosis, with special reference to pulmonary Xenon133 elimination.


Input: Phytohemagglutinin (PHA), the seed lectin of the common bean, accumulates in protein storage vacuoles of storage parenchyma cells in cotyledons.

Phytohemagglutinin

PHA

seed lectin


Input: New concepts of condyloma acuminata in children.


Input: When recombinant gE produced in HeLa cells was probed with the same antiphosphotyrosine antibody, a dimeric gE form at 130 kDa was detected on the cell surface.

recombinant gE

dimeric gE


Input: The levels of soluble L-selectin and ICAM-1 in the serum were determined by the ELISA method.

L-selectin


Input: The effect of lung edema on pulmonary vasoactivity of furosemide.


Input: Within the last few years, the WWW has grown enormously.


Input: Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions.

Saccharomyces cerevisiae MSH1

MSH2 genes


Input: These cells also showed an increase in cyclin A and cyclin A-and E-associated kinase activities characteristic of S phase induction.

cyclin A

cyclin A-and E-associated kinase


Input: Anisotropy of Hc2 and the breadth of the resistive transition of polycrystalline YBa2Cu


Input: TGF-beta1 induced phosphorylation of Smad2 and Smad3 in Mv1Lu mink lung epithelial cells.


Input: Changes in the frequency of X-chromatin in women under Prednisone therapy


Input: Obtaining kidney cells from a beagle puppy (RPB-1) and the establishment of a cryopreservation bank


Input: Microscopically, cartilage showed markedly stunted and disorganized endochondral ossification.


Input: When incubated with infective larvae which had penetrated mouse skin, both normal and immune cells attached to larvae in the absence of serum.


Input: During each step of the pulse infusion the osteocalcin responses to changes in CaI in general were parallel to the changes in PTH (r = 0. 462; P = 0. 02) and were inversely correlated to CaI (r =-0. 562; P = 0. 003).

osteocalcin

PTH


Input: GH signals by interacting with GH receptor (GHR).

GH

GH receptor

GHR


Input: These data suggest that overexpression of MT potentiates the growth of MCF7 cells, whereas downregulation of MT elicits antiproliferative effects.

MT

MT


Input: The induction by dexamethasone of rat liver CYP3A1 differs from classical glucocorticoid gene regulation in part because both glucocorticoids and antiglucocorticoids such as pregnenolone 16 alpha-carbonitrile (PCN) induce CYP3A1 through transcriptional gene activation.

rat liver CYP3A1


Input: A pharmacokinetic interaction between LY354740 and diazepam, leading to the lowering of the plasma level of free diazepam, was also demonstrated.


Input: Also, in patients with MYD, there was a significant decrease in arterial PO2 from the seated posture to the supine posture, without a significant change in the arterial PCO2.


Input: The animals were followed over a 1-to 6-h posttraumatic course, and processed for the LM and TEM visualization of HRP.

HRP


Input: Glucose consumption of the human brain under the influence of intravenous infusions of glucose, glucagon and glucose-insulin

glucagon


Input: The signs of enterocolitis, pathological microbial flora in the stool and changes in the colon mucosa were absent.


Input: This study was undertaken to evaluate the physical and biological characteristics of nebulized interleukin 2 liposomes.

interleukin 2


Input: Although mutant pex5delta cells expressing a yeast/tobacco Pex5p chimaera failed to import a GFP-Eci1p reporter protein, they were able to grow on oleic acid.

mutant pex5delta

yeast/tobacco Pex5p chimaera

GFP


Input: Two human beta-1, 6-N-acetylglucosaminyltransferases forming the core 2 O-glycan branch, C2GnT and the I antigen, IGnT, are homologous to each other in three regions of the catalytic domain (A, B, C) and their genes reside at the same locus, chromosome 9, band q21 (Bierhuizen, M. F. A., Mattei, M.-G. and Fukuda, M., Genes Dev., 7, 468-478, 1993).

human beta-1, 6-N-acetylglucosaminyltransferases

I antigen

IGnT


Input: Previously, we had shown that interleukin 8 (IL-8) is constitutively expressed in HTLV-I-infected cells and in cells transiently expressing Tax.

interleukin 8

Tax


Input: We undertook this study to examine the relationship between systemic oxygen delivery (DO2) and tissue oxygen tension (TPO2) in hypovolemic shock.


Input: The lowest PaCO2 values were significantly lower in MCE than in the F, W, and D (F + W + D) group or controls.


Input: The psychosomatic approach to temporomandibular arthrosis


Input: Detection of sinusoidal gratings by pattern-specific detectors: further evidence for the correlation principle in human vision.


Input: The transcriptional start site (s) of the IA-2 gene was mapped by 5' rapid amplification of cDNA ends to 97 bp upstream of the translational start site.

IA-2 gene


Input: Function was retained when one copy of the sequence was present, suggesting that this sequence represents an essential element.


Input: The data also suggest that gamma CACCC box binding factors mediate LCR-gamma interactions which normally enhance gamma-globin and suppress beta-globin gene expression in fetal erythroid cells.

gamma CACCC box binding factors

LCR-gamma

gamma-globin

beta-globin gene


Input: Left ventricle to coronary sinus fistula.


Input: No other transcripts of different length could be detected after prolonged exposure.


Input: We have isolated and sequenced cDNA sequences corresponding to two novel genes that map to Xq28.


Input: The vaccinia virus D6R open reading frame encodes the small subunit of the heterodimeric vaccinia virus early transcription factor (VETF) that activates transcription of early genes in vitro.

vaccinia virus early transcription factor

VETF

early genes


Input: We have used nuclear magnetic resonance (NMR) to obtain the structure of an RNA " kissing " hairpin complex formed between the HIV-2 TAR hairpin loop and a hairpin with a complementary loop sequence.


Input: Xnr3 is transcriptionally activated by wnt signaling during gastrulation in the Xenopus embryo.

wnt


Input: In this report, we identify Tyr319 as a functionally important phosphorylation site in the ZAP-70 interdomain B region.

ZAP-70 interdomain B region


Input: Renal dysplasia with multisystem malformation--a study of 9 cases.


Input: Brome mosaic virus polymerase-like protein 2a is directed to the endoplasmic reticulum by helicase-like viral protein 1a.

Brome mosaic virus polymerase

protein 2a

helicase

viral protein 1a


Input: Mutations abolishing MalK function not only result in inability to transport maltose but also cause constitutive expression of the maltose regulon.

MalK

maltose regulon


Input: The D. discoideum proteins were entirely conserved over the four regions known to be important for GTP binding and all contained the C-terminal CAAX aa motifs shared by other Rho proteins.

Rho proteins


Input: The lack of chronically depressed LCBF (after 1 day) may be related to the quick structural repair of endothelium.


Input: Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukemia virus type 1-transformed human T cells.

Janus kinase 3


Input: An environmental investigation found evidence of suboptimal food storage and cooking temperatures at Restaurant A; cross contamination of foods may have contributed to the low attributable risk identified for chile rellenos.


Input: We used event-related functional magnetic resonance imaging (fMRI) during a cued spatial-attention task to dissociate brain activity related to attentional control from that related to selective processing of target stimuli.


Input: However, microinjection of reconstituted mRNPs into Xenopus oocytes demonstrates that although translational repression occurs in the absence of consensus RNA binding sequences for FRGY2, the presence of FRGY2 recognition elements within mRNA potentiates translational repression.

FRGY2 recognition elements


Input: Results of the study suggest that Chinese medicine use among this population depends on health conditions, and that having a regular source of care for Chinese medicine as well as a preference for Chinese medicine are two predictors for its use.


Input: A V1 mutant generated in vivo with 11 of the 14 N-terminal amino acids altered, was viable and produced symptoms typical of a wild-type infection.

V1 mutant


Input: These observations suggest that clr4 + and rik1 + must play a role in the assembly of Swi6p into a transcriptionally silent, inaccessible chromatin structure at fission yeast centromeres which is required to facilitate interactions with spindle microtubules and to ensure normal chromosome segregation.

clr4 +

rik1 +


Input: The gene sequence predicts a 150, 825 mol wt apoprotein of 1363 amino acids having an N-terminal hydrophobic signal sequence of 17 amino acids, 19 potential N-linked glycosylation sites, a hydrophobic anchor sequence of approximately 17 amino acids near the C terminus, and a hydrophilic cysteine-rich C terminus of 35 amino acids.


Input: Likewise, epidural morphine does not modify the intraoperative metabolic and hormonal responses.


Input: Only the native structure of phosphorylated ERK was recognized by VHR and was inactivated with a second-order rate constant of 40, 000 M-1 s-1.

ERK

VHR


Input: Omitting part of the experimental NOE-derived distances results in reduced restraint violations and lower R factors but impairs structural convergence in the rMD refinement.


Input: The region immediately following the promoter and 5' to ORF1 has a potential transcription terminator sequence.


Input: Cell cycle regulatory components have been largely conserved in eukaryotes; however, orthologs of neither CAK1 nor csk1 have been identified in other species to date.


Input: Within any cell line, several Tcfs and TLEs are co-expressed.

Tcfs

TLEs


Input: In marked contrast to the previously published human CD6 sequence, the mouse sequence predicts a long cytoplasmic tail that is not closely related to other proteins and possesses two proline-rich motifs containing the SH3-domain binding consensus sequence, three protein kinase C phosphorylation site motifs, nine casein kinase-2 phosphorylation site motifs, and a serine-threonine-rich motif repeated three times.

human CD6 sequence

SH3-domain binding consensus sequence

protein kinase C phosphorylation site motifs

casein kinase-2 phosphorylation site motifs


Input: The Xenopus homeobox gene twin mediates Wnt induction of goosecoid in establishment of Spemann' s organizer.

Xenopus homeobox gene twin

Wnt

goosecoid


Input: Quinethazone


Input: Divergent regions of the posterior left hemisphere used for decoding and storage of information emerged in each working memory versus control task comparison.


Input: Among the different epithelial cell lines tested, only RTS3b cells allowed an expression pattern similar to that observed in naturally infected benign condylomas.


Input: These involve (1) subcloning a promoterless sucCD fragment downstream of the lac promoter in M13mp10, and (2) precise splicing of the suc coding regions with the efficient atpE ribosome-binding site and expression from the thermoinducible lambda promoters in the pJLA503 vector.

sucCD fragment

lac promoter

suc coding regions

atpE ribosome-binding site


Input: Increase in [Ca + +] counteracted the effects of verapamil on RAD.


Input: Evidence for involvement of proteins HU and RpoS in transcription of the osmoresponsive proU operon in Escherichia coli.

HU

RpoS

proU operon


Input: In comparison to a silent baseline, CBF increases were observed in auditory cortex bilaterally and in the right superior parietal, right dorsolateral frontal, and right premotor regions, with no modulation as a function of attentional condition.


Input: Detonation-traumatic load during military service


Input: Deletion of CDC5 was lethal and resulted in a dumbbell-shaped terminal morphology, with the nuclei almost divided but still connected.


Input: Thus, the pathway to Fc epsilonRI-mediated MEK/ERK and ERK activation can apparently bypass Ras and Raf-1.

Fc epsilonRI

MEK

ERK

ERK

Ras


Input: Bovine anaplasmosis: susceptibility of seronegative cows from an infected herd to experimental infection with Anaplasma marginale.


Input: The starting dose was 8 mg/m2 administered intravenously (IV) as a short infusion daily for 5 days, repeated every 3 weeks with dose adjustments depending on patient tolerance.


Input: The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to p130cas.

adhesion focal tyrosine kinase


Input: The cerebellar cortical vessels: they are compared to the cerebral vessels.


Input: Plasma prolactin concentrations in pinealectomized ewes receiving melatonin treatment and in pineal intact ewes maintained under a non-24-hour photoperiod.

Plasma prolactin


Input: After 5 days stimulation with G-CSF (10 micrograms/kg) 1l of blood was drawn, kept unprocessed for 3 days and reinfused 24 h after completion of chemotherapy.

G-CSF


Input: The species composition and abundance upon treatment of manure with polyethylene, polystyrene and glass particles was similar to that of the treatment control, i. e. natural and inert sand.


Input: We present the case of a patient who presented an unusually large mucoid cyst measuring 38 x 25 mm in an uncommon localization, the right maxillary.


Input: Twenty male volunteers were studied during almokalant infusion aiming at plasma concentrations (Cpl) of 20, 50, 100, and 150 nmol/l.


Input: Previous studies have shown that TGFbeta1 expression is upregulated in mouse keratinocytes infected with a v-rasHa retrovirus, although the functional significance of this has not been clear.

v-rasHa


Input: A significant difference in the distribution of antibodies to thyroglobulin and thyroid peroxidase was found in subgroup 2.

thyroglobulin

thyroid peroxidase


Input: Protein kinase C (PKC) activation after treatment of human neuroblastoma SK-N-BE (2) C cells with phorbol 12-myristate 13-acetate (PMA) was found to enhance transcription of the human dopamine beta-hydroxylase (DBH) in those cells.

Protein kinase C

PKC

dopamine beta-hydroxylase

DBH


Input: Radiographic spatial frequencies essential to the diagnosis of incipient interproximal lesions.


Input: The originally embryonic gamma-globin locus duplicated and acquired a novel (fetal) pattern of expression in a defined time period (55-40 million years ago) during primate phylogeny.

embryonic gamma-globin locus


Input: The pcaR regulatory locus has been found to be required for both induction of all of the genes within the pca regulon (pcaBDC, pcaIJ, and pcaF) and the chemotactic response of the bacteria to aromatic compounds.

pcaR regulatory locus

pca regulon

pcaBDC

pcaIJ

pcaF


Input: Thus, the i-leader protein is a viral gene product of unknown function and high stability that is made in large quantities at intermediate times of productive infection. (ABSTRACT TRUNCATED AT 400 WORDS)

i-leader protein


Input: Consequently, during the evolution of mammals, it is the CKbeta4GT-I gene lineage that has been recruited for the biosynthesis of lactose.

CKbeta4GT-I gene


Input: The Pi signals are conveyed to PHO8 by binding of PHO4 protein, a positive regulatory factor, to a promoter region of PHO8 (PHO8p) under the influence of the PHO regulatory circuit.

PHO4 protein

PHO


Input: Direct saturation analysis


Input: The results of the neural network were compared with those of a density mask (thresholds,-750/-300 H), with a radiologist serving as the gold standard.


Input: Mutational analysis of the IME2 UAS reveals two critical sequence elements: a G + C-rich sequence (called URS1), previously identified at many meiotic genes, and a newly described element, the T4C site, that we found at a subset of meiotic genes.

IME2 UAS


Input: We analyzed right ventricular size and function and 201Tl uptake to determine if there was a relationship between 201Tl uptake and systolic function in 19 patients with pulmonary artery hypertension who were being evaluated for heart-lung transplantation.


Input: Clinical findings plaque index, PI; gingival index, GI; bleeding on probing, BOP; pus discharge, pus; and probing depth, PD at both PT-01 and control sites were measured at every visit for 4 weeks.


Input: Therefore the effect of GAL11 on PGK transcription must be mediated at the PGK UAS, presumably as part of the activation complex.

PGK

PGK UAS


Input: The authors recommend in cases with an elevated transaminase serum activity more frequent check-up examinations to avoid missing of a relapse, and to examine repeatedly IgM anti-HAV as in protracted forms of hepatitis IgM anti-HAV may persist even when the transaminase activity is normal.

IgM anti-HAV

IgM anti-HAV


Input: Effects were studied of extremely high-frequency electromagnetic radiation (EHF EMR) on indices for the immune and endocrine systems in a series of 48 patients presenting with hyperplastic processes in endometrium.


Input: Management of patients with Ewing' s sarcoma has been discussed with reference to the need to achieve an excellent local result from radiation therapy now that patients are experiencing long-term survival.


Input: Effect of hyperaemia on thallium-201 redistribution in normal canine myocardium.


Input: After dialysis online, lactate was converted by means of lactate oxidase immobilized to porous glass, and the depletion of oxygen was registered by means of a Clark electrode.

lactate oxidase


Input: These data show that both Sp1 and Sp3 transcription factors upregulate HGF promoter activity by binding to the Sp1 binding site at position-318 to-303 bp in the HGF gene promoter.

Sp3 transcription factors

HGF promoter

Sp1 binding site

HGF gene promoter


Input: As a member of the uncoupling protein family, UCP2 is ubiquitously expressed in rodents and humans, implicating a major role in thermogenesis.

uncoupling protein family


Input: 99Tcm-labelled albumin colloid, albures (radius 250 nm) or nanocoll (radius 25 nm), or both were used as test substances to study the kinetics of vascular clearance after RES stimulation.

albumin


Input: Hepatitis B markers in Lancashire police officers.


Input: Xa4 is a dominantly inherited rice gene that confers resistance to Philippine race 1 of the bacterial blight pathogen Xanthomonas oryzae pv. oryzae in rice.


Input: Screening of human cDNA libraries has identified two different 5'-termini and alternatively spliced forms of the human Fli-1 gene (Fli-1b), suggesting the possible existence of two independent promoters.

human Fli-1 gene


Input: We were unable to construct chvI or chvG insertion mutants of R. meliloti, whereas mutants carrying insertions outside of these genes were readily obtained.

chvI

chvG insertion mutants


Input: Consistent with an effect on transcription, p21 was localized in nuclei of transfected cells.


Input: When yeast cells reach a critical size in late G1 they simultaneously start budding, initiate DNA synthesis, and activate transcription of a set of genes that includes G1 cyclins CLN1, CLN2, and many DNA synthesis genes.

G1 cyclins CLN1


Input: After a 1-h rest (for T2 return to baseline), subjects repeated the 5-min protocol, followed by a final MRI/MRS.


Input: Use of ELISAs for the diagnosis of canine atopy.


Input: In situ localization of PCP-A1 transcripts revealed that they accumulate specifically in pollen at the late binucleate/trinucleate stage of development rather than in the tapetum, which previously was taken to be the principal source of the pollen coat.

PCP-A1 transcripts


Input: A single dose of Cef was administered intravenously to 11 patients with autoimmune diseases and varying degrees of renal impairment (Group I CLCR less than 50 ml/min, Group II CLCR greater than 50 ml/min).


Input: Postheparin lipoprotein lipase, measured using fat emulsion as substrate, also was significantly greater in female rats compared with males.

lipoprotein lipase


Input: RESULTS: Here, we report the identification of two major and novel Shc tyrosine phosphorylation sites, Y239 and Y240.

Shc


Input: The results obtained demonstrate the applicability of countercurrent chromatography to the determination of ultratrace elements.


Input: Based on our sequence data, ORF2 from most isolates excluding G1 encode truncated 49 aa (pORF2a) because of an in-frame stop codon, although ORF2s from most G1 isolates encode 202 aa (pORF2ab).


Input: Fusions between the GAL DNA binding domain and full-length mSin3 were also capable of repression.

GAL DNA binding domain

full-length mSin3


Input: Clinical evidence provides tentative suggestions on (a) possible additional risk of cigarette smoking (b) avoidance of venography (c) avoidance of varicose vein surgery.


Input: We examined the contribution of a cryptic plasmid, pRmeGR4b, to the nodulation of Medicago sativa by strain GR4 of Rhizobium meliloti.


Input: It is concluded that the predominant action of LSD on the female copulatory response is not mediated by increased dopamine receptor activity but that the LSD effect might be modulated by decreased dopaminergic activity.

dopamine receptor


Input: The frequency of severe congestive heart failure (Killip class III or IV) at admission was significantly higher in patients with early presentation, than with late presentation (30. 7% vs 7. 6%, p less than 0. 05).


Input: These findings also demonstrate that unless excluded by other factors, the C proteins are likely to be located along the length of nascent transcripts.

C proteins


Input: ADR1 in extracts made from glucose-repressed and-derepressed cells bound UAS1 DNA with similar affinities despite having greatly different abilities to activate ADH2 gene expression in vivo.

ADH2 gene


Input: Comparing the outcome of the group having histologically normal biopsies with the group having nonspecifically abnormal ones it is concluded that frontal biopsy is not of such high prognostic value as has been claimed in previous reports.


Input: However, using wet weight/dry weight methodology, we found that administration of U74006F significantly reduced water content in the right hippocampus (contralateral to the site of injury) compared to saline-treated animals (p less than 0. 05).


Input: A ready-made prosthesis is placed on the external side of the ribs vertically bridging the flailed chest segment, and fixed to the first upper and first lower intact rib as well as to the mobile segments of the affected ribs.


Input: The authors suggest that alprazolam may have enhanced specificity for a subpopulation of benzodiazepine receptors.

benzodiazepine receptors


Input: They showed moderate in vitro antifungal activity against a wide variety of fungi and yeasts including clinically important pathogens, and were highly effective in systemic infection with Candida albicans in mice after iv and im administrations.


Input: Central (heart rate, VE, VO2) or local (muscle and blood lactate, adenosine triphosphate, creatine phosphokinase, glycogen) cues highlighted in these studies demonstrate both the complexity of effort perception, and the need for better understanding of the physiological components upon which it is based.

creatine phosphokinase


Input: The method was tested on 7 rats with 48-hr-old myocardial infarction and 4 sham-operated controls.


Input: Disruption and reconstruction: narrative insights into the experience of family members caring for a relative diagnosed with serious mental illness.


Input: Transcription start sites of sal and salR genes were determined to lie 30-and 24-bp upstream of the respective initiation codons and separated from each other by 78 nucleotides.

sal

salR genes


Input: Co-operativity of functional domains in the muscle-specific transcription factor Myf-5.

muscle-specific transcription factor Myf-5


Input: Henry Quastler brought experience from an actual x-ray treatment, and Dr.


Input: Hybridization was detected between polyadenylated H chain mRNA, isolated from the majority of the hybridomas, and the VH probe.

polyadenylated H chain mRNA

VH


Input: The general concept of RARE-cleavage mapping as well as its applications and limitations are discussed.

RARE


Input: (4) Expression in different sites in the central nervous system is driven by separable elements widely dispersed throughout 8 kb 3' of the gene.


Input: Thus, an increase in lactate concentration of the magnitude observed during alkali therapy need not indicate a worsening of the metabolic picture in lactic acidosis.


Input: The virus must progress past the immediate-early phase and express an early gene product (s) for activation of cyclin E expression.

early gene product (s)

cyclin E


Input: The software is in BASIC adapted for the Hewlett-Packard calculators HP-9845B and HP-85A.


Input: Genealogical analysis suggested mainly a mother-to-offspring transmission of this STLV-1.


Input: The deduced amino-acid sequence of the mature enzyme showed very low homology (< 20. 4% identity) to those of known pectinolytic enzymes in the large pectate lyase superfamily (the polysaccharide lyase family 1).

pectate lyase superfamily

polysaccharide lyase family 1


Input: The pineal hormone melatonin (MLT) is able to exert an oncostatic action.


Input: Patients commonly considered the external frame cumbersome.


Input: A wound model for decubitus and leg ulcers consisting of human dermal fibroblasts in type I collagen dermal " equivalent " matrix (DEM) was exposed in vitro to electric fields similar to postulated endogenous fields in wounds.

type I collagen


Input: In contrast to the effect on DNA replication, the L13V substitution in large T antigen did not prevent complex formation with Hsc70 and the Rb protein.

large T antigen

Rb protein


Input: In contrast, the tail deviated ipsilaterally in cats with a hemisection, and the tail was ventroflexed in cats with a transection.


Input: Lastly, several restriction length polymorphisms were identified and mapped within a 1 kb region located immediately upstream from the JH cluster.

JH cluster


Input: Peak plasma ACTH responses were not significantly different between control and patient groups.

ACTH


Input: We demonstrate inhibition of 2-deoxyglucose uptake in isolated primary rat adipocytes and 3T3-L1 adipocytes pretreated with U73122.


Input: It is likely that these recordings are incomplete; the actual number of activated neurons is estimated to be about 300 in the acutely sensitized preparation.


Input: In this report we describe the structure and DNA sequence of transcriptional control regions from both human and Wistar-rat single copy EGF genes and their functional analysis in epithelial cell cultures.

human and Wistar-rat single copy EGF genes


Input: Along with these species, F. graminearum group 2 (ZON, DON and/or 3AcDON or 15AcDON); F. chlamydosporum; F. acuminatum (type-A trichothecene derivatives); and F. semitectum were often found to be associated.


Input: C. glabrata cells containing the CBF1 gene under the influence of a shutdown promoter (tetO-ScHOP) arrested their growth after 5 h of cultivation in the presence of the reactive drug doxycycline.

CBF1 gene


Input: It was observed that muscle infarction in the IPC (24 +/-2%) and preischemic LMK (21 +/-2%) groups were smaller (P < 0. 05) than that in the control (42 +/-2%).


Input: A characteristic feature is their tendency to form homo-and/or heterodimeric complexes.


Input: Copyright 1999 Academic Press.


Input: A female infant with isolated noncompaction of ventricular myocardium who developed ventricular tachyarrhythmia is described.


Input: Methodological considerations limiting causal assertions permissible with nonexperimental data are discussed.


Input: Skytthe, and K.


Input: Y1, Y2, and Y4/PP1.


Input: S-phase-promoting cyclin-dependent kinases (Cdks) and the kinase Dbf4-Cdc7 then act to initiate replication.

cyclin-dependent kinases

Cdks


Input: The cleft walls are lined with highly conserved residues and NADP is bound along one wall.


Input: The primary conditions for acceptable hospital use were that exhaled-volume monitoring be performed for all patients and that O2 monitoring be performed both when setting FIO2 and continuously when FIO2 levels are critical.


Input: Genetic mutation or loss of activin/transforming growth factor-beta (TGFbeta) receptor function has been shown in human lymphoid, breast, and colorectal tumors as well as Hep2B and Mv1Lu cell lines.

activin

transforming growth factor-beta (TGFbeta) receptor


Input: Non-specific immunological abnormalities were detected in 8 of the 13 patients in whom they were looked for.


Input: No cleavage of gp 130 was observed in analogous pulse-chase radiolabelling of Ad-gB-infected human fibroblasts, even though these cells are permissive for HCMV replication and can process the native gB molecule.

gp 130

gB

native gB molecule


Input: Because levels of Vo2DIR and Vo2INDIR were similar in both groups, we pooled data from septic and control animals.


Input: A case comparison of acquired immune deficiency syndrome (AIDS) in homosexual males with spindle-endothelial cell abnormalities and with recrudescent melioidosis.


Input: OBJECTIVE: To assess laboratory practice in the examination of blood films for malarial parasites.


Input: Little honoured in his own country: statues in recognition of Edward Jenner MD FRS.


Input: We conclude that GRF1 and GRF2 can form homo-and hetero-oligomers via their DH domains, that mutational inactivation of oligomer formation by GRF1 is associated with impaired biological and signaling activities, and that in 293T cells GRF1 mediates at least two pathways for Raf activation: one a constitutive signal that is mainly Ras-dependent, and one an ionomycin-induced signal that cooperates with the constitutive signal without further augmenting the level of GTP-Ras.

DH domains

Raf

Ras

GTP-Ras


Input: The significance of these changes in relation to the control of phosphorus balance in ruminants is discussed.


Input: These results extend our knowledge of this SNF2-like family member and suggest a role for PASG in leukemogenesis.

SNF2-like family member

PASG


Input: In the absence of c-fos gene expression, c-Fos protein appears to be replaced by proteins of Fos family (Fra-1) and ATF family (ATF-2 and ATFa).

c-fos gene

c-Fos protein

Fos family

ATF family

ATFa


Input: The interaction obtained with DBM scores was further qualified by a three-way interaction that limited this pattern to participants scoring higher on self-deception.


Input: To elucidate the molecular mechanism by which the Ras signaling pathway activates a cell-type-specific gene, we have used the pituitary-specific rat prolactin (rPRL) promoter as a target of oncogenic Ras and Raf in GH4 rat pituitary cells.

Ras

pituitary-specific rat prolactin

rPRL

oncogenic Ras

Raf


Input: The results indicate that expression of proU in E. coli is directed from two promoters, one (P2) characterized earlier by other workers with the start site of transcription 60 nucleotides upstream of the initiation codon of the first structural gene (proV), and the other (P1) situated 250 nucleotides upstream of proV.

proU

proV

proV


Input: Coexpression of CREB-binding protein (CBP)/p300 with TReP-132 has an additive effect on promoter activity, and the proteins were demonstrated to interact physically.

CREB-binding protein

CBP


Input: Thirty minutes after reperfusion, lung lymph flow (QL) increased from 4. 3 to 8. 3 ml/30 minutes (p less than 0. 05), lymph/plasma protein ratio was unchanged from 0. 6, and the lymph protein clearance increased from 2. 6 to 4. 6 ml/30 minutes (p less than 0. 05), data consistent with increased microvascular permeability.


Input: The shift from complex I to complex II seen only in SCM-1-producer T cell lines upon activation was completely suppressed by cyclosporin A.


Input: Database searches revealed a 50-63% similarity and 34-42% identity with several families of serine proteases, in particular the trypsin-like proteases, members of the glandular kallikrein family (including prostate-specific antigen, nerve growth factor gamma, and epidermal growth factor-binding protein) and the activators for the kringle family proteins (including the human tissue plasminogen activator and human hepatocyte growth factor activator).

serine proteases

trypsin-like proteases

glandular kallikrein family

prostate-specific antigen

nerve growth factor gamma

epidermal growth factor-binding protein

kringle family proteins

human tissue plasminogen activator

human hepatocyte growth factor activator


Input: UPR elements present in other ER chaperone genes, such as yeast KAR2 (BiP), mammalian GRP78 (BiP), and GRP94, function in an analogous manner to that in FKB2.

yeast KAR2

BiP

mammalian GRP78

BiP


Input: No bafilomycin-sensitive ATPase is detected in a vacuolar fraction.

ATPase


Input: The kinase domains encoded in the COOH-terminal moiety are 94% conserved; the NH2-terminal moieties are approximately 65% homologous, suggesting this region may encode sequences conferring differential regulation of the two kinases.


Input: From this asymmetry, we suggested previously that GCN4 interacts with nonequivalent and possibly overlapping half-sites (ATGAC and ATGAG) that have different affinities.


Input: The essential questions about hepatitis C


Input: DRAP27 is recognized by CD9 antibodies.

CD9 antibodies


Input: YACs selected from our contig will be the starting point for the cloning of the LGMD2B gene and thereby establish the biological basis for this form of muscular dystrophy and its relationship with the other limb-girdle muscular dystrophies.

LGMD2B gene


Input: Acceptability of home monitoring as an aid to conception.


Input: Starches had no effect.


Input: The dominant inhibitory biological activity of the N terminus correlated with its ability to impair EGF-dependent activation of GTP-Ras and of MAP kinase, as well with the ability of endogenous Sos to form a stable complex with activated EGF receptors.

EGF

GTP-Ras

MAP kinase

Sos

EGF receptors


Input: The tensile strengths of an adhesive luting resin' Panavia EX' to the bovine dentin decreased significantly by the zinc iontophoresis.


Input: The Giessener Tumordokumentationssystem (GTDS) is such a disease specific system.


Input: In addition, renal sympathetic activity was measured in a separate group of rats.


Input: A 4. 0-kb Nlk message is also present during embryogenesis, detectable at day E10.

Nlk message


Input: The 5-HT3 antagonist ondansetron reduced alcohol intake in both the medium and high alcohol preferring rats at doses between 0. 01 and 0. 16 mg/kg.


Input: In humans, there was a statistically significant decrease of TEWL on both forearm and thigh in CS-treated patients compared to non-CS-treated patients and controls (p less than 0. 05).


Input: Southern hybridization of genomic DNA from WT and Lp/Lp embryos failed to identify specific rearrangements at or near the Nhlh1 locus, and Northern RNA blotting and RT-PCR evaluation of Nhlh1 mRNA expression indicated that both the levels and types of Nhlh1 mRNAs produced in WT and Lp/Lp embryos were indistinguishable.

Lp

Lp

Nhlh1 locus

Nhlh1 mRNA

Nhlh1 mRNAs

Lp

Lp


Input: Mutations of the human PTEN gene.

human PTEN gene