Input: To evaluate the effects of HRT on those factors in end-stage renal disease (ESRD) patients, we evaluated the changes of lipid profile, coagulation and fibrinolysis markers, and plasma homocysteine levels after treatment.


Input: There was a weak significant correlation between TGF beta 1 levels and normal cell radiosensitivity (lymphocyte SF2).

TGF beta 1


Input: Acute feasibility and safety of a smoking reduction strategy for smokers with schizophrenia.


Input: Tightly ordered proteasomal degradation of proteins critical for cell cycle control implies a role of the proteasome in maintaining cell proliferation and cell survival.


Input: The sixth nucleotide was bulged out to allow stacking of this U. G pair on the adjacent helical region.


Input: Functional analysis of the mutant desmin in SW13 (vim-) cells showed aggregation of abnormal coarse clumps of desmin positive material dispersed throughout the cytoplasm.

mutant desmin

vim

desmin


Input: Patients with lesions affecting the PRC but sparing the PHC, and patients with lesions affecting both PRC and PHC, performed an oculomotor delayed response task with unpredictably varied memory delays of up to 30 s.


Input: In addition, 26 amino acid residues, K69, D88, E94, D134, R154, K169, H197, D233, G235, G236, G237, F238, E274, G276, R277, Y278, K294, Y323, Y331, D332, C360, D361, D364, G387, Y389, and F397 (mouse ODC numbering), all of which are implicated in the formation of the pyridoxal phosphate-binding domain and the substrate-binding domain and in dimer stabilization with the eukaryotic ODCs, were also conserved in S. ruminantium LDC.

ODC

ODCs

LDC


Input: The Psc2 cDNA contained an open reading frame homologous to CP2 family proteins.

Psc2 cDNA

CP2 family proteins


Input: Our results indicate that Shh can drive continued cycling in immature, proliferating CGNPs.

Shh


Input: The QT interval was related to various components of the insulin resistance syndrome, including BP and insulin sensitivity.

insulin

insulin


Input: The wavenumbers corresponding to the normal modes of vibration were calculated using the DFT (B3LYP/6-31G * *) approximation and their agreement with the measured values improved after scaling of the associated force field.


Input: The data provide strong evidence that ThlA is involved in the metabolism of both acid and solvent formation, whereas the physiological function of ThlB has yet to be elucidated.

ThlA

ThlB


Input: In addition, npm3, which is usually coactivated with fgf8 by MMTV insertion, was not up-regulated by androgens in SC-3 cells.


Input: Experiments with epitope-tagged proteins show that UEV1A is a nuclear protein, whereas both Kua and Kua-UEV localize to cytoplasmic structures, indicating that the Kua domain determines the cytoplasmic localization of Kua-UEV.

Kua

Kua

UEV

Kua domain

Kua

UEV


Input: Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription. p53 protein activity as a transcription factor can be activated in vivo by antibodies that target its C-terminal negative regulatory domain suggesting that cellular enzymes that target this domain may play a role in stimulating p53-dependent gene expression.

human p53

p53 protein


Input: Interestingly, this mutant cell line lacks expression of the IKK regulatory protein, IKKgamma.

IKK regulatory protein

IKKgamma


Input: The Tax/IKKgamma interaction serves to recruit Tax to the IKK catalytic subunits, IKKalpha and IKKbeta, and this recruitment appears to be an essential mechanism by which Tax stimulates the activity of IKK.

Tax

IKKgamma

Tax

IKK catalytic subunits

IKKalpha

IKKbeta

Tax

IKK


Input: An anchored AFLP-and retrotransposon-based map of diploid Avena.


Input: In addition, we identified a novel type of inhibitory domain in the N-terminal 60 amino acids of IRF-1 which strongly inhibits its transcriptional activity.


Input: Simultaneous determination of theophylline and its metabolites by HPLC] A high performance liquid chromatography (HPLC) method has been developed for the simultaneous determination of theophylline and its metabolites, with caffeine and its metabolites.


Input: Ten males performed both test conditions and oxygen uptake VO2, heart rate, minute ventilation VE, perceived exertion and spinal shrinkage were recorded.


Input: CONCLUSION: SPT is more useful than WST in differentiating patients predisposed to aspiration.


Input: Studied groups were (1) untreated control, n = 12; (2) FK-1, n = 8; (3) FK-3, n = 8.


Input: DNA binding and glutathione S-transferase pull-down assays demonstrate that binding requires Elk-1 (1-212) but not the C-terminal transactivation domain.

glutathione S-transferase

Elk-1 (1-212)


Input: Unexpectedly, ALK7 signaling produced a remarkable change in cell morphology characterized by cell flattening and elaboration of blunt, short cell processes.


Input: The swa2-1 allele recovered from the original screen carries a point mutation in its tetratricopeptide repeat (TPR) domain, a motif not found in auxilin but known in other proteins to mediate interaction with heat-shock proteins.

swa2-1 allele

auxilin

heat-shock proteins


Input: In slightly older embryos, the expression was skewed to one side of the embryo and by E6. 5, at the onset of gastrulation, expression was seen in the epiblast, visceral endoderm, nascent mesoderm, and the primitive streak.


Input: The authors proposed that the highly convergent inputs to the entorhinal cortex indicate this region may be particularly important for selecting or compressing information.


Input: Influence of oil emulsions and diphenyl on post-harvest physiconutritional changes in Kagzi limes (Citrus aurantifolia) was studied.


Input: Detailed analysis of alpha1, 3GT transcripts revealed two major alternative splicing patterns in the 5'-untranslated region (5'-UTR) and evidence for minor splicing activity that occurs in a tissue-specific manner.

alpha1, 3GT transcripts


Input: A thermal Kubo-Martin-Schwinger condition arises due to the coupling of a computer to a strong periodic source, namely, the daily and weekly usage patterns of the system.


Input: The non-homologous sequences in the 5' untranslated regions might be acquired at or after transcription during retrotransposition of the ATLN elements.


Input: The time course of RNA1 replication and RNA3 synthesis in induced yeast paralleled that in yeast transfected with natural FHV virion RNA.


Input: The transcription and alternative splicing of human ORL1 and GAIP are cell-type specific.

human ORL1

GAIP


Input: The extraction was subsequently rated as' easy' or' difficult'. Taking Pell-Gregory class C as a predictor of a' difficult' extraction, specificity was 88% but sensitivity was low at 15%.


Input: In addition, our results show that ERKs and PI3Ks can synergise to convert ectoderm into mesoderm.

ERKs


Input: Nevertheless, protein kinase A stimulation induces CREMalpha to activate the complex native promoter in the phosphoenolpyruvate carboxykinase (PEPCK) gene.

protein kinase A

CREMalpha

phosphoenolpyruvate carboxykinase

PEPCK


Input: Another putative HNF3 site in close apposition to a NF1/CTF site was localized upstream of the silencer-like element.

HNF3 site

CTF


Input: A recently reported new member of the Vav family proteins, Vav3 has been identified as a Ros receptor protein tyrosine kinase (RPTK) interacting protein by yeast two-hybrid screening.

Vav family proteins

Ros receptor protein tyrosine kinase

RPTK


Input: Subsequently, we show that the reexpression of the r-PTPeta gene in highly malignant rat thyroid cells transformed by retroviruses carrying the v-mos and v-ras-Ki oncogenes suppresses their malignant phenotype.

r-PTPeta gene

v-mos

v-ras-Ki oncogenes


Input: Induced expression of Rnd3 is associated with transformation of polarized epithelial cells by the Raf-MEK-extracellular signal-regulated kinase pathway.

Raf

MEK


Input: The activity of the transcription factor CREB is regulated by extracellular stimuli that result in its phosphorylation at a critical serine residue, Ser133.

transcription factor CREB


Input: When 10 fields were analysed, a strong relationship was found between the presence of bacteria on Gram staining and the final diagnosis of VAP (for PSB and PTC respectively: sensitivity 74 and 81%, specificity 94 and 100%, positive predictive value 91 and 100%, negative predictive value 82 and 88%).


Input: Tranilast in the Therapy of Coronary Artery Disease.


Input: This study is a further and more extensive validation of the clinician rated NIMH-LCM-p.


Input: The Aie1 locus was mapped to mouse chromosome 7A2-A3 by fluorescent in situ hybridization.

Aie1 locus


Input: Psychiatric disorders in children and adolescents carry considerable morbidity, impede development, and carry a significant mortality by suicide.


Input: Thyrotoxicosis due to amiodarone is difficult to treat and is further complicated by the pro-arrhythmic potential of thyrotoxicosis and the fading antiarrhythmic effect after amiodarone withdrawal.


Input: Chaperones/HSPs thus play important roles within cell cycle processes.

HSPs


Input: This study allows us to draw conclusions about the identity of proteins required for the development of the nervous system in Drosophila and provides an example of a molecular approach to characterize en masse transposon-tagged mutations identified in genetic screens.


Input: Children with ADD showed an attenuated frontal CNV-1 amplitude and a trend towards increased CNV-1 and CNV-2 occipital amplitudes.


Input: Where UMDNJ is headed.


Input: Overexpression of c-Myc in serum-starved human or mouse embryonic cells leads to apoptosis which is significantly reduced in the presence of growth factor-containing serum. c-Myc-induced apoptosis appears to be deficient in bax-null as compared with bax-wild-type mouse embryonic fibroblasts.

c-Myc

c-Myc

bax

bax


Input: METHODS: T2 *-weighted, three-dimensional gradient-echo images were acquired by exploiting the magnetic susceptibility difference between oxygenated and deoxygenated hemoglobin in the vasculature and microvasculature.

hemoglobin


Input: In the COPD patients, the variability of Delta-inst Rrs (30%) was greater than that of FOT Rrs (21%).


Input: Thus, Pet111p could play dual roles in both membrane localization and regulation of Cox2p synthesis within mitochondria.


Input: The determination of the double bounds in blood serum lipids by titration with ozone: the pathophysiology and diagnostic significance] In this article the method of definition of double binders in lipids of blood serum in patients with different diseases basically atherosclerosis and ischemic heart disease, with use titration by ozone is given.


Input: Ang II-induced fibronectin mRNA was not affected by PKC inhibitors or PKC depletion, whereas specific inhibition of EGF-R function by a dominant negative EGF-R mutant and tyrphostin AG1478 abolished induction of fibronectin mRNA.

Ang II

fibronectin

PKC

PKC

EGF-R

dominant negative EGF-R mutant

fibronectin mRNA


Input: Acoust.


Input: Video images of the nostrils were captured and then analyzed for area, perimeter, centroid, principal axis, moments about the major and minor axes (I11, I22), anisometry, bulkiness, lateral offset, internostril angle, and rotational angle.


Input: Young fish (Oreochromis mossambicus) were exposed to microgravity (micro g) for 9 to 10 days during space missions STS-55 and STS-84, or to hypergravity (hg) for 9 days.


Input: S6K2 is highly homologous to S6K1 in the core kinase and linker regulatory domains but differs from S6K1 in the N-and C-terminal regions and is differently localized primarily to the nucleus because of a C-terminal nuclear localization signal unique to S6K2.


Input: Pretreatment of cells with the mitogen-activated protein-extracellular signal-regulated kinase kinase (MEK) inhibitor U0126 inhibited S6K2 activation to a greater extent than S6K1.

mitogen-activated protein-extracellular signal-regulated kinase kinase

MEK


Input: T cells express two isoforms of S6k1: a 70 kDa cytoplasmic kinase and an 85 kDa isoform that has a classic nuclear localisation.


Input: Ketanserin, a hypotensive drug with 5-HT2 receptor antagonism, when administered by topical infusion of a 0. 25% w/v solution by corneal and scleral applications, was found to lower intraocular pressure with four times more activity than its metabolite, ketanserinol.

5-HT2 receptor


Input: A prospectively gated 2D axial sequence with velocity encoding in the craniocaudal direction in the cervical region was set at a velocity of +/-10 cm/s.


Input: It was subsequently shown that Tip60 had histone acetyltransferase (HAT) activity.

histone acetyltransferase

HAT


Input: Our data show that multiple MLSN1 transcripts, both constitutively expressed and inducible, are present in cultured pigmented melanoma cells, and suggest that MLSN1 expression can be regulated at the level of both transcription and mRNA processing.

MLSN1 transcripts


Input: These results also suggest the involvement of additional elements in the UPR.


Input: We show that in contrast to SRC1, direct binding of CBP to the estrogen receptor is weak, suggesting that SRC1 functions primarily as an adaptor to recruit CBP and p300.

CBP

estrogen receptor

CBP


Input: Remarkably, a construct corresponding to residues 631 to 970, which contains only the LXXLL motifs and the AD1 region of SRC1, retained strong coactivator activity in our assays.


Input: Since MEK acts as a cytoplasmic anchor for the ERKs, the lack of a MEK interaction resulted in the aberrant nuclear localization of ERK2-Delta19-25 mutants in serum-starved cells.

MEK

ERKs

MEK


Input: Pmt2 is a member of a six-protein family in yeast that catalyzes the first step in O mannosylation of target proteins.


Input: Of the 21 quadrants positive in the controls, 17 were correlated with previously detected jaw pathoses.


Input: Four cases of synovial chondromatosis are presented.


Input: Previous studies have shown that the pro-inflammatory cytokines tumor necrosis factor alpha and interferon gamma reduce the expression of the cystic fibrosis transmembrane conductance regulator (CFTR) gene (CFTR) in HT-29 and T84 cells by acting post-transcriptionally.

tumor necrosis factor alpha

interferon gamma

cystic fibrosis transmembrane conductance regulator

CFTR

CFTR


Input: Regulation of RhoA is required to maintain adhesion in stationary cells, but is also critical for cell spreading and migration [3].

RhoA


Input: Here we show in mouse fibroblasts stably transformed by v-Src that mRNA and protein levels of p21 (WAF1/CIP1), cyclin D1, and cyclin E are elevated.

v-Src

cyclin D1

cyclin E


Input: ORFA and ccdA were constitutively cotranscribed as determined by primer extension analysis.

ccdA


Input: Mouse Impact is a paternally expressed gene encoding an evolutionarily conserved protein of unknown function.

Mouse Impact


Input: Coexpression studies indicate that insulin and PKB suppress transactivation by C/EBPbeta, but not C/EBPalpha, and that N-terminal transactivation domains in C/EBPbeta are required.

insulin

PKB

C/EBPbeta

C/EBPalpha

C/EBPbeta


Input: Among eight graminaceous species tested, Ids3 expression was observed only in Fe-deficient roots of H. vulgare and Secale cereale. which not only secrete 2'-deoxymugineic acid (DMA), but also mugineic acid (MA) and 3-epihydroxymugineic acid (epiHMA, H. vulgare), and 3-hydroxymugineic acid (HMA, S. cereale).


Input: In contrast, high COUP-TFI expression impeded the neuronal differentiation of P19 cells induced with RA, resulting in cell cultures lacking neurons.

COUP-TFI


Input: Because PET is also useful for the pretreatment and follow-up evaluation, the use of stereotactic PET in these patients can enable an accurate comparison of PET-based metabolic data with MR-based anatomical data.


Input: Therefore, in our in vitro model, the localization of the mutation in the K-ras gene predisposes to a different level of aggressiveness in the transforming phenotype.

K-ras gene


Input: Here, we describe the isolation of MdPin1, a Pin1 homologue from the plant species apple (Malus domestica) and show that it has the same phosphorylation-specific substrate specificity and can be inhibited by juglone in vitro, as is the case for Pin1.


Input: These and other data presented suggest that TAg' re-models' host cell transcription factors that are used early in viral infection, and thereby mimics an event that naturally occurs during transformation.

TAg


Input: This sensitivity analysis showed that the practical limits of the accuracy of the used screening test jeopardize the estimation of the true herd prevalence within reasonable confidence limits, because the within-herd PTB true prevalence was low. For this reason we augmented the herd specificity for herds with larger adult herd size (> 5).


Input: ORFK10. 5 encodes a protein, latency-associated nuclear antigen 2 (LANA2), which is expressed in KSHV-infected hematopoietic tissues, including PEL and CD but not KS lesions.

ORFK10. 5

latency-associated nuclear antigen 2


Input: In Xenopus, BMPs act as epidermal inducers and also as negative regulators of neurogenesis.

BMPs


Input: Presently four unique variants carrying distinct GAF sequences in the N-terminal region have been identified.

GAF sequences


Input: Genomic organization of the human phosphodiesterase PDE11A gene.

phosphodiesterase PDE11A gene


Input: The present findings revealed that the rib-2 protein was a unique alpha1, 4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate.

rib-2 protein

alpha1, 4-N-acetylglucosaminyltransferase


Input: Inhibition of the Mek/Erk pathway in Rat1/ras cells, using the Mek inhibitor, PD98059, resulted in complete cytoskeletal recovery, indistinguishable from that induced by HR12.

Mek

Erk

ras

Mek


Input: The transcription factor CHOP/GADD153 gene is induced by cellular stress and is involved in mediating apoptosis.

CHOP


Input: Addition of synthetic tyrosine-phosphorylated peptides derived from betac cytoplasmic tyrosines prior to GM-CSF stimulation inhibited the in vitro activation of STAT5.

GM-CSF


Input: MAIN OUTCOME MEASURES: Percentage change in the apnea-hypopnea index (AHI; apnea events + hypopnea events per hour of sleep) and odds of developing moderate-to-severe SDB (defined by an AHI > or = 15 events per hour of sleep), with respect to change in weight.


Input: Paraneoplastic rheumatic syndromes.


Input: This article reviews recent information on the frequency, characteristics, and possible pathogenic mechanisms of the vasculitides occurring in patients with the main connective tissue diseases.


Input: Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain.

Tec kinase

phosphatidylinositol 3-kinase

Tec pleckstrin homology domain


Input: Current evidence for this type of DNA supercoiling-dependent transcriptional coupling, based largely on the in vivo activities of promoters contained in engineered DNA constructs, suggests that the transcription complex must be physically hindered to generate DNA supercoils and to prevent their diffusion throughout the DNA duplex.


Input: The structure of the free SH2 domain has been compared to that of the SH2 complexed with a doubly phosphorylated peptide derived from polyomavirus middle T antigen (MT).

SH2 domain

polyomavirus middle T antigen

MT


Input: We have identified three binding sites for protein complexes: a palindrome, a direct repeat, and a C + T sequence that corresponds to seven GAGA motifs on the transcribed strand.


Input: Copyright 2000 Academic Press.


Input: Patients underwent pretreatment cystoscopy and detailed tumor mapping, and were treated with 75 mg./m. 2 cisplatin on day 1 and 1 gm./m. 2 daily, 5-fluorouracil on days 1 to 4 and definitive radiotherapy.


Input: All 9 untreated patients underwent laparoscopy, which identified 3 intra-abdominal, 3 vanished and 2 peeping testes, and 1 atrophic testis in the inguinal canal.


Input: This philosophy was instituted for the compound RP 73401, a specific phosphodiesterase IV inhibitor, that was being developed simultaneously for delivery by both oral and pulmonary routes of administration.

phosphodiesterase IV


Input: Increased levels of anticardiolipin immunoglobulin G may also cause bleeding.

anticardiolipin immunoglobulin G


Input: RESULTS: Prevalence of obesity (BMI SDS > 2. 0) was < 2% at diagnosis, but increased to 16% at 3y.


Input: One of the sequelae of the antiphospholipid-antibodies is an impaired uteroplacental circulation.


Input: Bupropion to aid smoking cessation.


Input: Using a natural dominant negative for AP-1 transcriptional activity in ROS 17/2. 8 cells, we then showed that AP-1 transcription factors mediated TGF-beta1-and BMP-2-regulated expression of the (alpha1) collagen I gene as well as TGF-beta1-regulated expression of the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor.

AP-1 transcription factors

(alpha1) collagen I gene

parathyroid hormone

PTH

PTH-related peptide (PTHrP) receptor


Input: PM 12 or 18 mg/kg daily plus a standard dose of SB for 21 days was statistically more effective than SB in producing a final cure for patients with VL in Bihar, India.


Input: There were significant differences (p < 0. 05) between the fracture and nonfracture groups in the total femur BMD (13%), trabecular BMD in the distal radius (4%), and the fractal dimension in the radiographs (FD2) (3%).


Input: BACKGROUND: The aim of this study was to determine and compare interleukin-6 (IL-6) levels in gingival crevicular fluid (GCF) and clinical periodontal findings in patients with rheumatoid arthritis (RA) and adult periodontitis (AP).


Input: In a prospective, multicentre trial the efficacy of an Vitex agnus castus L extract Ze 440 was investigated in 50 patients with pre-menstrual syndrome (PMS).


Input: Studies are necessary to assess the source of contamination and potential role of MRSA-contaminated milk in the transmission of MRSA to neonates.


Input: Depending on treatment exposures, this at-risk population may experience life-threatening late effects, such as cirrhosis secondary to hepatitis C or late-onset anthracycline-induced cardiomyopathy, or life-changing late effects, such as cognitive dysfunction.


Input: The presence of locus-specific residues throughout the entire promoter region strongly suggests that the various HLA class I loci are differentially regulated.

HLA class I loci


Input: Because the number of parameters required by a Volterra series grows rapidly with both the length of its memory and the order of its nonlinearity, methods for identifying these models from measurements of input/output data are limited to low-order systems with relatively short memories.


Input: The standard method for calculating the composite score on the S-B IV excludes subtests with a raw score of 0, which overestimates cognitive functioning in young biologically high risk children.


Input: NiCl (2)-induced MCP-1 synthesis required activation of NF-kappaB since mutation of NF-kappaB-binding sites in the promoter resulted in complete loss of inducible promoter activity.

NF-kappaB

NF-kappaB-binding sites


Input: Engagement of human CD2 by mitogenic pairs of anti-CD2 mAb induces tyrosine phosphorylation of a number of intracellular proteins including a 120 kDa phosphoprotein that we identify as the proto-oncogene c-Cbl.

human CD2

anti-CD2 mAb

proto-oncogene c-Cbl


Input: Validity of NIR spectroscopy for quantitatively measuring muscle oxidative metabolic rate in exercise.


Input: Previous studies have demonstrated that tissue-restricted transcription factors including PU. 1 and PU. 1 interaction partner (PIP) function synergistically with c-Fos plus c-Jun to stimulate the kappaE3'-enhancer in 3T3 cells.

PU. 1

PU. 1 interaction partner

PIP

c-Fos

c-Jun


Input: The murine int-6 locus, identified as a frequent integration site of mouse mammary tumor viruses, encodes the 48-kDa eIF3e subunit of translation initiation factor eIF3.

murine int-6 locus

48-kDa eIF3e subunit of translation initiation factor eIF3


Input: An int6 deletion (int6Delta) mutant was viable but grew slowly in minimal medium.

int6 deletion


Input: We produced transgenic plants expressing the antisense Arabidopsis HD (AtHD1) gene.

antisense Arabidopsis HD


Input: Four transcription initiation sites have been identified by full-length RNA ligase-mediated rapid amplification of cDNA ends (RLM-RACE) between-61 and-32 bp from the translation initiation codon. Reverse transcription-PCR analysis revealed that PFK-A, PFK-B and PFK-C genes were expressed, in all mouse tissues tested, at varying levels.

RNA ligase

PFK-A

PFK-B

PFK-C genes


Input: PFK-A mRNA was more abundantly expressed in all tissues than were the PFK-B and PFK-C genes.

PFK-A

PFK-B

PFK-C genes


Input: We used the Toshiba IIDR system, which is composed of an X-ray TV system and a digital image managing circuit.


Input: In whole sardine, domoic acid was detected in levels exceeding sometimes the regulatory limit.


Input: Closeup: a resource for nurses who smoke.


Input: [18F] (+)-4-fluorobenzyltrozamicol (FBT), which selectively binds to the vesicular acetylcholine transporter in the presynaptic cholinergic neuron, has previously been shown to be a useful ligand for the study of cholinergic terminal density in the basal ganglia with PET.

acetylcholine transporter


Input: We demonstrate that the protein is a murine homologue of SAF-A which has been shown to bind selectively to MARs and is responsible for the satMa-binding activity in the chromatographic fractions.

murine homologue of SAF-A

satMa


Input: The molecular associations dictating INCENP behavior during mitosis are currently unknown.

INCENP


Input: Ang II significantly induced Ang2 mRNA accumulations without affecting Ang1 or Tie2 expression, which was inhibited by protein kinase C inhibitors and by intracellular Ca (2 +) chelating agents.

Ang II

Ang2 mRNA

protein kinase C


Input: Promoter analysis demonstrated that the sequence identical to consensus cAMP-responsive element (CRE) located at-481 of the SMemb promoter was critical for Hex responsiveness.

SMemb promoter

Hex


Input: LH/CG receptor activation of ARNO is not mediated by activation of phosphatidylinositol 3-kinase (PI 3-kinase) or by G protein beta gamma subunits.

LH/CG receptor

ARNO

phosphatidylinositol 3-kinase

PI 3-kinase

G protein beta gamma subunits


Input: Deletion analysis showed that the-321/+ 41 sequence was sufficient for both the constitutive promoter activity and auto-activation and electrophoretic mobility shift assays identified the interaction of C/EBPs and Sp1 to this region.

C/EBPs


Input: Termination of induced VT on the first attempt was comparable with BV pacing (87. 4%) versus RV pacing (89. 6%).


Input: We compare the results of this algorithm with the results obtained with two other algorithms, the optimal algorithm for monochannel nonoverlapping noise and the optimal algorithm for multichannel additive noise, and we show that in both cases improvement can be obtained.


Input: Changes in stimulation levels over time in nucleus 22 cochlear implant users.


Input: A marked decrease in the type 1 insulin-like growth factor (IGF) receptor (IGF-IR) occurs in prostate epithelial cells during transformation from the benign to the metastatic state.

type 1 insulin-like growth factor (IGF) receptor

IGF-IR


Input: The P69 cell line was derived by immortalization of human primary prostate epithelial cells with simian virus-40 T antigen and is rarely tumorigenic.

simian virus-40 T antigen


Input: We determined whether the human StAR promoter is responsive to sterol regulatory element-binding proteins (SREBPs).

human StAR promoter

sterol regulatory element-binding proteins

SREBPs


Input: Expression of SREBP-1a stimulated StAR promoter activity in the context of COS-1 cells and human granulosa-lutein cells.

StAR promoter


Input: Because the high-density lipoprotein receptor (HDL-R) is a key element in cholesterol homeostasis and a potential therapeutic target for hypercholesterolemic drugs, an understanding of HDL-R regulation is essential.

high-density lipoprotein receptor

HDL-R

HDL-R


Input: IFN-stimulated gene factor-3 and STAT1 homodimers formed and bound an IFN-stimulated response element (ISRE) and gamma-activated sequence (GAS) element, respectively.

IFN-stimulated gene factor-3

STAT1 homodimers

IFN-stimulated response element

ISRE

gamma-activated sequence

GAS


Input: We have therefore studied the molecular mechanisms of TGF-beta1 action on thyroglobulin (TG) gene expression by focusing our attention on TGF-beta1 regulation of thyroid-specific transcription factors.

thyroglobulin

TG


Input: The epitope-protected lysine (K) was present in a 30-aa TPO fragment that, by N-terminal sequencing, was found to be K713.

30-aa TPO fragment


Input: To understand the molecular regulation of these genes in thyroid cells, the effect of thyroid transcription factor 1 (TTF-1) and the paired domain-containing protein 8 (Pax-8) on the transcriptional activity of the deiodinase promoters were studied.

thyroid transcription factor 1

paired domain-containing protein 8

deiodinase promoters


Input: Regional blood blow was measured by means of microspheres in predefined regions of the C6, T11, and L6 vertebrae.


Input: Activation of transcription through the AP-1 site in Jurkat cells by JunD and/or Fra-2 was weak. c-Jun, JunB, and c-Fos activation was greater, although the level was still less than that with Tax.

AP-1 site

JunD

c-Jun

JunB

c-Fos

Tax


Input: The mechanism of ligand-activated estrogen receptor alpha (ERalpha)-dependent activation of gene expression through the SRE was determined by mutational analysis of the promoter, analysis of mitogen-activated protein kinase (MAPK) pathway activation by E2, and transforming growth factor alpha (TGF-alpha) as a positive control.

estrogen receptor alpha

ERalpha

mitogen-activated protein kinase

MAPK

transforming growth factor alpha

TGF-alpha


Input: CONCLUSIONS: Under current immunization practices, the authors estimate that nearly 13, 000 Asian and Pacific Islander children living in the United States today will become infected with HBV in the future, resulting in more than 600 liver carcinoma deaths.


Input: We observed NP/NMP4/CIZ expression in osteocytes, osteoblasts, and chondrocytes in rat bone.

NP

CIZ


Input: Chlamydia and cervical cancer: a real association?


Input: A novel approach was developed for identifying transcription factor activities associated with NGF-activated, but not EGF-activated, signaling, using random oligonucleotide clones from a DNA recognition library to isolate specific DNA binding proteins from PC12 nuclear extracts.

NGF

EGF


Input: NGF elicits a more delayed and sustained ERK phosphorylation than EGF, consistent with previous reports.

NGF

ERK

EGF


Input: NGF, but not EGF, enhances the upper bands, corresponding to phosphorylated Fra-2.

NGF

EGF

phosphorylated Fra-2


Input: The actA gene is present as a single copy in the genome of A. chrysogenum; and its expression level, opposite to pcbC and cefEF cephalosporin biosynthetic genes, was steady during cephalosporin fermentation, showing a single 1. 4-kb transcript.

actA gene

pcbC

cefEF cephalosporin biosynthetic genes


Input: Adding 10 mmol SDS/l led to transient inhibition of acidification, metal solubilization and sulfur oxidation.


Input: We have investigated the role of NGF in regulating gene transcription in PC12 and INS-1 cells, in order to define if there are NGF-regulated genes per se.

NGF

NGF


Input: Nine animals served as control animals, whereas 20 animals received a focal arachnoid scar at C1-C2, which was produced by placement of a kaolin-soaked fibrin sponge on the posterior surface of the spinal cord.

fibrin


Input: The Schistosoma mansoni homologue (SmSmad2) was overexpressed in bacteria as a Sj26-GST fusion protein and used to raise specific antibodies.

Schistosoma mansoni homologue

GST


Input: These data indicate that the SmSmad2 responds to the TGF-beta signals by interaction with receptor I, which phosphorylates it, whereupon it translocates into the nucleus presumably to regulate target gene transcription and consequently elicit a specific TGF-beta effect.

TGF-beta

receptor I

TGF-beta


Input: Intact Flag-tagged protein products from all six were produced from genomic expression vectors, although the ORF40/41 transcript encoding a primase-helicase component proved to be spliced with a 127-bp intron.

primase

helicase


Input: Expression of the src homology 3 (SH3)-encoding, expressed in tumorigenic astrocytes (SETA) gene is associated with astrocyte transformation in culture and tumors in the adult brain.

src homology 3

SETA


Input: METHODS: One hundred fourteen consecutive patients (mean age 61 years) with focal pancreatic masses, detected on CT, underwent EUS-FNA by using a linear-array echoendoscope and 22-gauge needles.


Input: METHODS: Thyroid status was measured at baseline (1990-93), through assessment of serum antibodies to thyroid peroxidase (TPO-Abs, positive: > 10 IU/ml), serum TSH levels, and when TSH was abnormal (< 0. 4 or > 4. 0 mU/l), serum thyroxin levels (T4).

thyroid peroxidase

TPO-Abs

serum TSH

TSH

serum thyroxin


Input: We suggest that ventriculopleural shunting should be considered as the preferred alternative to peritoneal drainage in children with intra-abdominal adhesions or with a history of recent peritoneal infection.


Input: TBARS levels, oxygen-radical absorbing capacity assay and AFR release assessed by electron paramagnetic resonance (EPR) were used to explore the existence of oxidative stress in diabetes.


Input: Long-range comparison of human and mouse SCL loci: localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences.

human and mouse SCL loci


Input: To account for this observation, other possible causes include increased CSF pulsation in children creating motion artifact, changes in arterial oxygen concentration intrinsic to propofol or related to the supplemental oxygen normally administered, or changes in CSF protein levels related to propofol binding to proteins for uptake into CSF.


Input: The utilities measured in our study can be applied directly to quality-of-life determinations in clinical trials of adjuvant IFN alpha-2b to measure the net benefit of therapy.

IFN alpha-2b


Input: Serum PTH tended to increase in the WL group but not in the WM group (P < 0. 06).

Serum PTH


Input: Structure of the EMAPII domain of human aminoacyl-tRNA synthetase complex reveals evolutionary dimer mimicry.

EMAPII domain

human aminoacyl-tRNA synthetase complex


Input: METHODS: The passive and active transport of fluorescein through the BRB was quantitated by vitreous fluorometry.


Input: Nerve growth factor (NGF) and retinoic acid (RA) exert important actions on PC12 cells.

Nerve growth factor

NGF


Input: The region containing both serines is homologous to the N-terminal destruction box of IkappaBalpha,-beta, and-epsilon.

IkappaBalpha,-beta, and-epsilon


Input: This function requires not only the kinase domain of Csk, but also its Src homology 3 (SH3) and SH2 regions.

Csk

Src homology 3


Input: Furthermore, we showed that ERSF including NF-Y and ATF6alpha and/or beta and capable of binding to ERSE is indeed formed when the cellular UPR is activated.

ERSF

NF-Y

ATF6alpha and/or beta


Input: These effects were not seen with SHIP2 possessing a mutation in the SH2 domain (R47G).

SH2 domain


Input: The gonadotrope-specific and regulated expression of the GnRH receptor (GnRH-R) gene is dependent on multiple transcription factors that interact with the noncanonical GnRH-R activating sequence (GRAS), the activator protein-1 (AP-1) element, and the steroidogenic factor-1 (SF-1) binding site.

GnRH receptor

GnRH-R

noncanonical GnRH-R activating sequence

GRAS

activator protein-1

steroidogenic factor-1


Input: METHODS: A structured interview was undertaken at the time of initial consultation and at subsequent 1-year intervals regarding type of BHS, frequency of spells, associated phenomenon, sequelae, family history, and age at termination of spells.


Input: In three cases (21. 4%), the MR imaging was interpreted as negative, but microscopic tumor was shown around seroma on reexcision.


Input: Methylation at both cytosine residues in the E2F element ((m) CG (m) CG) generated a new methylcytosine-specific DNA-protein complex.


Input: These mutations, when placed in a wild-type fliF background, had no mutant phenotype.

wild-type fliF


Input: As well, IFN-gamma-induced expression of IRF-1 and its binding to the IRF element is inhibited.

IFN-gamma

IRF element


Input: This molecule, wH22xeGFP, consists of the entire humanized anti-FcgammaRI mAb H22 with eGFP genetically fused to the C-terminal end of each CH3 domain. wH22xeGFP binds within the ligand-binding region by its Fc end, as well as outside the ligand-binding region by its Fab ends, thereby cross-linking FcgammaRI.

entire humanized anti-FcgammaRI mAb H22

eGFP

CH3 domain

Fc

Fab

FcgammaRI


Input: This interaction is reciprocal, since C/EBP dimer binding to a strong C/EBP site leads to enhanced CREB-1 recruitment to ATF/CREB sites that are weakly bound by CREB.

C/EBP dimer

C/EBP site

ATF

CREB

CREB


Input: The metabolic events occurring at or near that structure and involving cyclin D3 cause the translocation of ICP0 to the cytoplasm.

cyclin D3


Input: Transient transfections showed that a single mutation (556M) decreased TBLV enhancer activity at least 20-fold in two different T-cell lines.

TBLV enhancer


Input: Vector stocks containing envelope proteins from three different SIVmac clones, namely, SIVmac239 (T-lymphocyte tropic [T-tropic]), SIVmac316 (macrophage tropic [M-tropic]), and SIVmac1A11 (dualtropic), were tested.

envelope proteins


Input: Quantitative PCR studies indicated that synthesis and transport of vector DNA into the nucleus were similar for macrophages infected with the clone 239 and 316 pseudotypes, suggesting that the restriction for SIVmac239 infection is after reverse transcription and nuclear import of viral DNA.


Input: Thus, the anti-interferon functions of vIRF-2 may contribute to the establishment of a chronic or latent infection.

anti-interferon


Input: Interestingly, the activity of IkappaB kinase (IKK-beta), which plays an essential role in NF-kappaB activation through IkappaB phosphorylation, was largely enhanced in paclitaxel-treated cells, detected as IkappaBalpha phosphorylation.

IkappaB kinase

IKK-beta

NF-kappaB

IkappaB

IkappaBalpha


Input: We propose that TFOs represent a therapeutic potential to specifically diminish the expression of c-sis/PDGF-B proto-oncogene in various pathologic settings where constitutive expression of this gene has been observed.

c-sis

PDGF-B


Input: Rapid evolution of the DNA-binding site in LAGLIDADG homing endonucleases.

LAGLIDADG homing endonucleases


Input: Copyright 2001 Academic Press.


Input: Interestingly, the similarities with the endophilin proteins cover the entire sequence of the SH3GLB family, suggesting a common fold and presumably a common mode of action.

endophilin proteins

SH3GLB family


Input: Mental rotation of paired figures engendered activation in the left superior parietal lobule and the right frontal medial gyrus.


Input: We also reported the identification of three corresponding alternative first exons and an intronic promoter in the human PDE5A gene.

human PDE5A gene


Input: The glucose/insulin stimulation was inhibited by the addition of polyunsaturated fatty acids.

insulin


Input: In the present work, the complete genome sequences of Pyrococcus horikoshii and Pyrococcus abyssi, two species in a genus of hyperthermophilic archaeon (archaebacterium), were compared to detect large genome polymorphisms linked with restriction-modification gene homologs.


Input: This animal model of dystonia appears to be a model of NAD in man from the viewpoint of treatment-response.


Input: Peripheral and preemptive opioid antinociception in a mouse visceral pain model.


Input: Twenty-six (55%) (95% CI, 41-69%) patients experienced > or = grade 3 acute toxicity (RTOG).


Input: No' TATA' motif was identified near either the GABPalpha or ATPsynCF6 transcription start sites.

GABPalpha


Input: Significantly higher lung function parameters were obtained in extubated recipients of LPD preserved grafts 2 weeks after TX.


Input: Acquired antithrombin deficiency in sepsis.

antithrombin


Input: In addition, we have isolated a genomic fragment containing the most distal 5' sequences of the major GGT mRNA in HepG2 cells.

GGT mRNA


Input: (1997) Nature 387, 370-376)], we suggest that the metal fluoride ions replaced phosphate at the two ATP-binding sites of the iron protein, Kp2.


Input: Expression of herpes simplex virus type 2 US3 affects the Cdc42/Rac pathway and attenuates c-Jun N-terminal kinase activation.

herpes simplex virus type 2 US3

Rac

c-Jun N-terminal kinase


Input: If you think education is expensive--try ignorance--Bok' s Law.


Input: To study the in vivo role of p16. 7, a phi29 mutant containing a suppressible mutation in gene 16. 7 was constructed.

p16. 7

gene 16. 7


Input: To the best of our knowledge, SNTCS is highly malignant.


Input: The extraordinary stability of peptide--gp96 complexes and the plasticity of the peptide-binding pocket support the proposed relay of diverse peptides to MHC and/or other molecules via molecular recognition.

peptide--gp96 complexes

MHC


Input: High-affinity binding of NF-1 to PSE-B, but not to PSE-A, was confirmed by competition of DNA-protein interactions by using NF-1 DNA elements and antibodies.

PSE-B

PSE-A


Input: Coexpression of the p120 (ctn) protein with an N-terminal deletion, which eliminates some potential tyrosine phosphorylation sites, or the protein with a single amino acid substitution (tyrosine at 217 to phenylalanine) resulted in an increase in the aggregation of v-Src-transformed EL and EalphaCL cells.

ctn

v-Src


Input: We show that p73 can transcriptionally inhibit a number of cellular and viral promoters.


Input: RESULTS: Of the 24 patients, 6 had Grade 1 pneumonitis, and 13 had Grade 2 pneumonitis.


Input: In contrast, we did not detect a significant correlation between plasma TNFalpha and radiation pneumonitis.

plasma TNFalpha


Input: METHODS: Sixteen pigs were assigned randomly to control and shock groups.


Input: Identification of pulmonary vein stenosis after radiofrequency ablation for atrial fibrillation using MRI.


Input: Tumor cell lines transduced at an MOI of 8 for 3 days led to > 90% gene transfer efficiency.


Input: Treatment includes both medical and surgical options, with medical therapy further subclassified into pharmacologic and pneumatic dilation.


Input: Finally, we compared the differential screening techniques in terms of sensitivity, efficiency and occurrence of false positives.


Input: Serial US images were obtained before and 20, 30, 40, 50, 60, 90, 120, 150, 180, 240, and 300 s after intravenous injection of 2 g of contrast agent using conventional and harmonic PD US.


Input: To investigate the effects of exogenous hyaluronic acid, the development of port-site metastasis was examined using mouse adenocarcinoma cell-line colon 26 cells.


Input: Cytomegalovirus, Chlamydia pneumoniae, and Helicobacter pylori IgG antibodies and restenosis after stent implantation: an angiographic and intravascular ultrasound study.

IgG antibodies


Input: Responses of single-unit carotid body chemoreceptors in adult rats.


Input: Architecture and anatomy of the genomic locus encoding the human leukemia-associated transcription factor RUNX1/AML1.


Input: Therefore, we suggested that both proteins might belong to the PLTP family.

PLTP family


Input: In this paper the tyrosine dephosphorylating enzymes, the protein-tyrosine phosphatases (PTPs), are studied which can be grouped into two subfamilies, the soluble PTPs and the receptor PTPs (RPTPs).

protein-tyrosine phosphatases

PTPs

soluble PTPs

receptor PTPs

RPTPs


Input: The Ig-related, typical metazoan, module is classified to the disulphide lacking Ig members and represents the phylogenetic earliest member of this group.

Ig

Ig members


Input: The Sox gene family (Sry like HMG box gene) is characterised by a conserved DNA sequence encoding a domain of approximately 80 amino acids which is responsible for sequence specific DNA binding.

Sox gene family

Sry like HMG box gene


Input: While these results are consistent with previously reported effects of the C-terminal domain on nucleotide binding, they also demonstrate that interactions with the N-terminal domains are necessary to inhibit proton transport.


Input: Respiratory parameters suggested that M6G produced less respiratory depression than morphine.


Input: This supports previous arguments for the improbability of biological effects at UHF frequencies unless a mechanism can be found for accumulating energy over time and space and focussing it.


Input: To assess the maximum oxygen uptake (V' O2 max) of Hong Kong Chinese children and to explore its association with respiratory illnesses, we conducted the Multistage Fitness Test (MFT), a 20-m shuttle run test, in 1, 427 schoolchildren aged between 8-12 years.


Input: By analyzing 5'-deletion insulin promoter-reporter constructs in transient transfections of clonal INS-1 beta-cells, we located activating Hh-responsive regions within the rat insulin I promoter that include the glucose-response elements Far (E2) and Flat (A2/A3).

insulin promoter-reporter constructs

INS-1 beta

Hh

rat insulin I promoter


Input: The androgen receptor (AR) amino-terminus imposes androgen-specific regulation of AR gene expression via an exonic enhancer.

androgen receptor

AR

AR gene


Input: A major mechanism by which estrogens prevent osteoporosis seems to be repression of transcription of NF-kappa B target genes, such as the osteoclast-activating cytokines interleukin-6 and interleukin-1.

NF-kappa B target genes


Input: To identify the important cis-DNA regulatory element (s) involved in the tissue-, region-, and cell-specific expression of the mE-RABP gene, the 5-kb DNA fragment was sequenced.

mE-RABP gene


Input: In the mouse, both genes reside in the syntenic region 8E1 on chromosome 8.


Input: Analysis of the genome sequence revealed 26, 588 protein-encoding transcripts for which there was strong corroborating evidence and an additional approximately 12, 000 computationally derived genes with mouse matches or other weak supporting evidence.


Input: The corresponding genotype was determined with a restriction enzyme-based assay.


Input: By Caveman.


Input: Multistage models and the A-bomb survivor data: implications for carcinogenic mechanisms?


Input: The revitalization of surgery for Parkinson' s disease (PD) has fueled discussion about the best methodology to define the target.


Input: Corneal scrapping and deep stromal biopsy were obtained and stained for microscopic evaluation with periodic acid-Schiff, Giemsa, and Gomori' s methenamine silver stains.


Input: These results indicate that BACM has antiplaque and stronger antidegradation effects than GLCM.


Input: Multidrug resistance in Saccharomyces cerevisiae mainly results from the overexpression of genes coding for the membrane efflux pumps, the major facilitators and the ABC binding cassette transporters, under the control of key transcription regulators encoded by the PDR1 and PDR3 genes.

ABC binding cassette transporters

PDR3 genes


Input: Susceptibility to ischemia-induced arrhythmias was lower in 1-week diabetics: only 42% of diabetic hearts exhibited ventricular tachycardia (VT) and 16% had short episodes of ventricular fibrillation (VF) as compared to VT 100% and VF 70% (including sustained VF 36%) in the non-diabetics (P < 0. 05).


Input: A picture is emerging showing a gradient of function among p53, p73, p63 ranging from tumor suppression to development.


Input: This could lead to subsequent outbreaks if Babesia carrier animals were to be introduced into the herd.


Input: Contagious bovine pleuropneumonia is a major threat for cattle in Africa.


Input: Baseline BMD values were significantly lower in the oligo-amenorrheic group than in the two others at the level of lumbar spine (anteroposterior view: 0. 941 +/-0. 039 in oligo-amenorrheic vs 1. 077 +/-0. 029 or 1. 051 +/-0. 017 g x cm (-2), P < 0. 005, in the eumenorrheic and contraceptive user groups, respectively) but not in weight-bearing bone such as proximal and midshaft femur.


Input: The distribution of red rice cultivation in Sri Lanka is coincident with the HIDD villages.


Input: The increase in number of terminal hairs, which are defined as hairs more than 60 microm in diameter, in the designated area (0. 5 cm square = 0. 25 cm2 area) of the procyanidin B-2 group subjects after the 6-month trial was significantly greater than that of the placebo control group subjects (procyanidin B-2, 1. 99 +/-2. 58 (mean +/-SD)/0. 25 cm2; placebo,-0. 82 +/-3. 40 (mean +/-SD)/0. 25 cm2; P < 0. 02, two-sample t test).


Input: Ectopic expression of the dominant mutant Lg3 allele is believed to cause the phenotype.

dominant mutant Lg3 allele


Input: High plasma AVP levels observed in the two cases suggest that SSRIs stimulate AVP secretion, thereby causing SIADH.

plasma AVP

AVP


Input: Thus, in T47D breast carcinoma cells, IL-6 acts in synergy with EGF receptor autocrine activity to signal through the MAPK/PI3K pathways.

EGF receptor

MAPK


Input: Human homologue of yeast Rad23 protein A interacts with p300/cyclic AMP-responsive element binding (CREB)-binding protein to down-regulate transcriptional activity of p53.

Human homologue of yeast Rad23 protein A

cyclic AMP-responsive element binding (CREB)-binding protein


Input: Most patients harboring metronidazole-and clarithromycin-resistant strains were eradicated at an equal rate by each of the three regimens.


Input: Binding of cell type-specific nuclear proteins to the 5'-flanking region of maize C4 phosphoenolpyruvate carboxylase gene confers its differential transcription in mesophyll cells.

maize C4 phosphoenolpyruvate carboxylase gene


Input: RESULTS: During the stabilization period, PaCO2 (mean +/-SD) was 33 +/-5 mm Hg, and arrhythmias were not detected.


Input: BACKGROUND: Previous studies have indicated that the 60-, 30-, 28-and 12-item versions of the General Health Questionnaire (GHQ) are liable to retest effects, especially when administered multiple times with short intervals.


Input: Acute effects of LI 160 (extract of Hypericum perforatum, St John' s wort) and two of its constituents on neuroendocrine responses in the rat.


Input: Decreased serum ceruloplasmin and copper levels in cervical dystonia.

serum ceruloplasmin


Input: A microsporidian, Nosema algerae Vavra and undeen, was found parasitizing larvae and adults of a laboratory colony of Culex pipiens L. originated from Gharbia Governorate.


Input: Molecular cloning and characterization of OsPSK, a gene encoding a precursor for phytosulfokine-alpha, required for rice cell proliferation.

OsPSK

phytosulfokine-alpha


Input: Plasma DHE concentration rose promptly above 5 ng/ml after the application of the PSA tape onto the damaged skin in hairless rat.


Input: Implications in biomonitoring of the observed accumulation patterns, especially in the different tissues of Posidonia oceanica, are discussed.


Input: Thus, Xlim-1 not only contains a unique tyrosine-rich activation domain but also contains a negative regulatory domain in CT239-403, suggesting a complex regulatory mechanism underlying the transcriptional activity of Xlim-1 in the organizer.


Input: After allowing time for absorption, participants completed a bridge simulator task.


Input: Functional analysis of various PTP-deficient DT40 B cell lines stably expressing wild-type chimeric Fc gamma RIIB1-PECAM-1 receptor indicated that cytoplasmic Src homology 2-domain-containing phosphatases, SHP-1 and SHP-2, were both necessary and sufficient to deliver inhibitory negative regulation upon coligation of BCR complex with inhibitory receptor.

PTP

Fc gamma RIIB1-PECAM-1 receptor

cytoplasmic Src homology 2-domain-containing phosphatases

BCR complex


Input: Substitutions in the YFV Ag-binding region (ABR) occur at four of the eight highly conserved residues that are essential for binding of peptide-Ag in the class Ia molecules.

YFV Ag-binding region

ABR


Input: Similarly, curcumin (diferuloylmethane), an anti-inflammatory agent, suppressed OSM-stimulated STAT1 phosphorylation, DNA-binding activity of STAT1, and c-Jun N-terminal kinase activation without affecting JAK1, JAK2, JAK3, ERK1/2, and p38 phosphorylation.

OSM

c-Jun N-terminal kinase


Input: In contrast, the failure of the QKTT motif and TGN46 cytoplasmic tail to induce steady-state ER localization of vesicular stomatitis virus glycoprotein (VSVG) chimeras in HeLa and NRK cells indicates that significant differences in early secretory trafficking also exist.

vesicular stomatitis virus glycoprotein

VSVG


Input: A cDNA clone encoding C2H2-type zinc finger protein, SCOF-1, was isolated from soybean.

C2H2-type zinc finger protein


Input: Consistent with the specificity observed for the interaction of DmCKIIalpha with these bHLH proteins, sequence alignment suggests that only m5, m7, and m8 contain a consensus site for phosphorylation by CKII within a subdomain unique to these three proteins.

DmCKIIalpha

bHLH proteins

CKII


Input: Apart from antimicrobial properties, recent data indicate that PMN also exert anti-inflammatory effects by stimulation and release of cytokine antagonists such as interleukin-1 receptor antagonist (IL-1ra).

interleukin-1 receptor antagonist


Input: The purpose of this investigation was to study the morphological characteristics of the fibrous tissue capsule resulting from the implantation of aluminum calcium phosphate (ALCAP) and hydroxyapetite (HA) bioceramics.


Input: Sevelamer hydrochloride (Renagel) is a nonabsorbed phosphate-binding polymer marketed for the treatment of hyperphosphatemia in adult patients receiving hemodialysis.


Input: The pharmacokinetic profiles of digoxin and warfarin were not altered by the simultaneous and continued administration of sevelamer.


Input: Before PO3 administration, more than half (57. 4%) of the patients received only 1 or 2 antituberculous drugs (ethambutole and ethionamide or ethambutole and oprofloxacin).


Input: Can survival be prolonged for patients with hormone-resistant prostate cancer?


Input: Patients were divided into two group; Control group A in which a hot-water circulating system was used and group B in which a transtracheal heating and humidification system by ANAMED HUMITUBE was used, during gastric cancer operation.


Input: The present data also demonstrate that ectopic expression of blr1 increased JNK/SAPK activity, but JNK/SAPK activation was not needed for accelerated RA-induced differentiation and growth arrest.

JNK

SAPK

JNK

SAPK


Input: RESULTS: The parameters SF2 and plating efficiency were stable throughout the 4-year test period.


Input: Also, small, sense and antisense approximately 22 nt RNAs, derived from the satRNA, were associated with the replicating satellite.


Input: VE-DEF animals had significantly higher (p < 0. 05) levels of myocardial lipid peroxidation and lower (p < 0. 05) protein thiols following I-R compared to the CON animals.


Input: Grippers with integrated piezoresistive force sensors and with attached strain gauges have been reported.


Input: The child left behind.


Input: Transition between P-and H-BPPV was found in 6 cases.


Input: The contrasting effects of dopaminergic stimulation on the motor performance and on some aspects of cognitive processing suggest the existence of complex interactions within pre-and postsynaptic brain dopamine receptors, and an intervention of segregated basal ganglia-prefrontal cortex loops in motor and cognitive behaviour.

brain dopamine receptors


Input: HexA71 negatively affects RpoS, as the levels of this alternative sigma factor are higher in the HexA-mutant than in the HexA + strain.

RpoS

sigma factor

HexA-mutant

HexA +


Input: Multiple copies of rsmB + DNA, on the other hand, stimulate exoenzyme production by relieving the negative effects of a chromosomal copy of hexA +.

rsmB + DNA

hexA +


Input: 0%) and IL-12 (42. 6% vs.


Input: Systematic review of diagnostic tests for vaginal trichomoniasis.


Input: CHAP and the Department of Veterans Affairs.


Input: More importantly, this fusion converted a less effective vaccine into one with significant potency against established E7-expressing metastatic tumors.


Input: We compared previously the methylation status between normal liver and liver tumors in SV40 T/t antigen transgenic mice (MT-D2 mice) using Restriction Landmark Genomic Scanning for Methylation (RLGS-M) and identified several loci/spots that appeared to be methylated frequently in liver tumors.

SV40 T/t antigen


Input: The Genescan program predicted an open reading frame of a novel, intron-less gene adjacent to the B236 spot that encodes a putative 493-amino acid protein containing the SNAG repressor motif in the NH2-terminal region and five C2H2-type zinc finger motifs in the COOH-terminal half.


Input: Northern blot analysis revealed that mlt 1 is normally expressed in brain, spleen, stom ach, and liver.

mlt 1


Input: Treatment of N18TG-2 cells with a demethylating agent, 5-aza-deoxycytidine, resulted in an expression of mlt 1, indicating that the repression of mlt 1 is attributable to methylation Thus, mlt 1 is a novel target gene that is silenced by methylation during liver tumorigenesis initiated by SV40 T antigen.

mlt 1

mlt 1

mlt 1

SV40 T antigen


Input: These results suggested a critical role for tyrosine residue 1229 in the regulation of L1 endocytosis.


Input: Folate metabolism in the human malaria parasite Plasmodium falciparum is an essential activity for cell growth and replication, and the target of an important class of therapeutic agents in widespread use.


Input: The BFA System reads a text file with flows, measured with fluorescent microsphere technique, and constructs the lung anatomy with volumetric pixels showing the flows with a color schema.


Input: Retinoids participate in the onset of differentiation, apoptosis and the inhibition of growth in a wide variety of normal and cancerous cells.


Input: These results indicate that evaluation of exposure to S. neurona by WB analysis of serum may be misleading in young horses.


Input: Drosophila Menin1 gene transcripts use alternative polyadenylation sites resulting in 4. 3 and 5-kb messages.

Drosophila Menin1 gene transcripts


Input: Sequence analysis indicates that RBP21 shares homology with other retinoblastoma-binding proteins in the pRb-binding motif LxCxE at the C-terminal region.

retinoblastoma-binding proteins

pRb-binding motif


Input: In addition, the consensus amino acid motif for serine threonine receptor kinases was also present.

serine threonine receptor kinases


Input: We have also isolated and analyzed the 5' flanking region of the pea 33RNP gene.

33RNP gene


Input: OsBBPI was found to be rapidly induced in rice seedling leaf in response to cut, exogenous jasmonic acid (JA), and two potent protein phosphatase 2A (PP2A) inhibitors, cantharidin (CN) and endothall (EN), in a light/dark-, time-and dose-dependent manner; this induction was completely inhibited by cycloheximide (CHX), indicating a requirement for de novo protein synthesis in its induction.

OsBBPI

cut

protein phosphatase 2A


Input: The effects of chlordiazepoxide (2. 5-15. 0mg/kg), a full benzodiazepine receptor agonist, and bretazenil (5. 0-30. 0mg/kg), a partial benzodiazepine receptor agonist, were examined in the murine elevated plus-maze paradigm.

benzodiazepine receptor

benzodiazepine receptor


Input: However, plasmids carrying the yeast TyrRS gene could not be stably maintained in E. coli.

yeast TyrRS gene


Input: In mammalian tissue culture cells, overexpression of any of the four mouse deltex homologs suppressed the transcriptional activity of E47, a basic helix-loop-helix (bHLH) protein, in a manner similar to suppression by an activated form of human Notch1 or human DTX1.

basic helix-loop-helix (bHLH) protein

human Notch1

human DTX1


Input: Multiparous women presented higher BMI (P = 0. 01) and PBF (P = 0. 03) compared with primi-and nulliparous groups.


Input: The authors did not detect any significant correlations between parameters of the lipids of bone marrow and leptin levels in serum and bone marrow.

leptin


Input: The position of the analyst as expert: yesterday and today.


Input: Our results suggest that the central role of the Notch-CBF1/RBP-Jkappa signaling pathway in cell fate decisions renders it susceptible to pathways of viral replication and oncogenic conversion.

Notch

RBP-Jkappa


Input: Using a novel method combining chromatin immunoprecipitation and genomic array hybridization, we have identified a 460-kb CENP-A-binding DNA domain of a neocentromere derived from the 20p12 region of an invdup (20p) human marker chromosome.

460-kb CENP-A-binding DNA domain


Input: We describe a total of 39 DEAH helicases in these four species.

DEAH helicases


Input: Two cases with marked chronic arm lymphoedema reported major and persistent improvements in arm volume for at least 12 months after treatment with HBO2.


Input: The sensitivity of human neuroblastoma cells SK-N-SH to undergo apoptosis induced by thapsigargin was examined.


Input: Prophylactic lymph node dissection or radiation therapy to the nodal chain may decrease local recurrence but does not consistently affect overall survival.


Input: Currently, the clinical use of 5-aminolaevulinic acid (ALA) induced protoporphyrin IX (PPIX) for photodynamic therapy (PDT) is limited by the maximum tolerated oral ALA dose (60 mg/kg).

protoporphyrin IX

PPIX


Input: We can classify antibiotics into two groups based on initial bactericidal activity against P. aeruginosa; one class is antibiotics having rapid initial killing such as AMK, IPM and PAPM, the other is CAZ, MEPM showing slow initial killing.


Input: Managing HIV.


Input: In Klinefelter' s syndrome (47XXY), serum testosterone levels are at the lower end of the normal range and dihydrotestosterone levels are low.


Input: The histamine H1 receptor antagonists (antihistamines) are an important class of medications used for the relief of common symptoms associated with hyperhistaminic conditions occurring in children and adults.

histamine H1 receptor


Input: Conclusion: The Lp (a) levels in these children were the lower ever reported.

Lp (a)


Input: A subset of patients (n = 30) underwent multichannel pressure flow studies, which demonstrated that transrectal HIFU reduces bladder outflow obstruction.


Input: AIMS: To establish a baseline and intraindividual fluctuations of the tumour markers CEA, CA 50 and CA 242 in patients cured from colorectal cancer, and to test the hypothesis that serum concentrations and intraindividual fluctuations do not differ from the concentrations in cancer-free individuals.

CEA

CA 50

CA 242


Input: The homologous active-site framework of these enzymes with distinct structures suggests convergent evolution of a common catalytic mechanism.


Input: We found that RhoA can initiate a linear kinase cascade leading to the activation of ERK6 (p38 gamma), a recently identified member of the p38 family of MAPKs.

RhoA

p38 gamma

p38 family


Input: We show that several heme-responsive mechanisms combine to regulate DAN/TIR gene expression.

DAN

TIR


Input: In strains lacking tup11 and tup12, the atf1-pcr1 transcriptional activator continues to play a central role in fbp1-lacZ expression; however, spc1 MAPK phosphorylation of atf1 is no longer essential for its activation.

lacZ

spc1 MAPK


Input: In vitro binding studies demonstrate that eIF-5A is required for efficient interaction of Rev-NES with CRM1/exportin1 and that eIF-5A interacts with the nucleoporins CAN/nup214, nup153, nup98, and nup62.

Rev

NES

CAN


Input: Structural studies have shown that class I major histocompatibility complex (MHC)-restricted peptide-specific T cell receptor (TCR)-alpha/betas make multiple contacts with the alpha1 and alpha2 helices of the MHC, but it is unclear which or how many of these interactions contribute to functional binding.

class I major histocompatibility complex

MHC

T cell receptor (TCR)-alpha/betas

MHC


Input: Mice homozygous for the dlg mutation exhibit growth retardation in utero, have hypoplasia of the premaxilla and mandible, have a cleft secondary palate, and die perinatally.

dlg


Input: Moreover, a complex containing PTP phi, paxillin, and a paxillin-associated tyrosine kinase, Pyk2, can be immunoprecipitated from macrophage lysates, and the catalytic domain of PTP phi selectively binds paxillin and Pyk2 in vitro.

PTP phi

paxillin

paxillin-associated tyrosine kinase

PTP phi

paxillin


Input: A single base change (A8G) in either sequence reduces hnRNP A2 binding and, in the case of A2RE-2, inhibits RNA transport.

hnRNP A2


Input: Baseline variables associated with CD included a less frequent use of prestroke aspirin and a higher incidence of early CT changes of edema or mass effect or dense middle cerebral artery sign.


Input: IL-1beta was significantly higher in endometrioma than in lesions of other localizations.


Input: A complete drug history was compiled, specifying the amount and duration of VGB medication.


Input: The mutant receptors, as well as sBMPR-IA, were expressed as fusion proteins with thioredoxin in Escherichia coli, and purified using reverse phase high performance liquid chromatography (RP-HPLC) after digestion with enterokinase.

sBMPR-IA

thioredoxin

enterokinase


Input: The authors undertook a retrospective analysis of pathology with quantification of the percentage of papillary serous component (% PSC) and p53 expression.


Input: For this purpose, the immediate and the final (after swelling) fixation strengths of two variations of the swellable bone anchor designs (a smooth anchor and a screw anchor) were measured in two different foams (used to simulate bone) with different densities.


Input: Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells.

collagen gene


Input: Cloning and characterization of the murine beta (3) integrin gene promoter: identification of an interleukin-4 responsive element and regulation by STAT-6.

murine beta (3) integrin gene

interleukin-4 responsive element


Input: CONCLUSIONS: Although the levels of oxLDL antibodies might be modified in early hypertension, once advanced coronary artery disease has developed the presence of hypertension does not affect anti-oxLDL levels.

oxLDL antibodies

anti-oxLDL


Input: GafChromic (MD-55-2) radiochromic film has become increasingly popular for medical applications and has proven to be useful for brachytherapy dosimetry.


Input: RESULTS: Within 7 days, all groups re-acquired responding for heroin under CRF at rates similar to their pre-lesion performance.


Input: Cis-acting CCAAT elements are frequently found in eukaryotic promoter regions.


Input: Twenty-five patients also received PET examinations during the staging procedures.


Input: The Gap69C is a single-copy gene producing a major 2. 1-kb mRNA throughout development, but its amount is decreased in larvae.


Input: Cases of lung cancer with intramedullary metastasis are rare, especially those diagnosed before death.


Input: A novel growth-related nuclear protein binds and inhibits rat aldolase B gene promoter.

aldolase B gene


Input: OBJECTIVE: To investigate the association between complete congenital heart block (CCHB) in the fetus and adult disease.


Input: This study examined the role of cholesteryl ester transfer (CET), cholesteryl ester transfer protein (CETP) activity, and phospholipid transfer protein (PLTP) activity in the increased prevalence of coronary artery calcification (CAC) in diabetic subjects compared with nondiabetic subjects and in the loss of the sex difference in CAC in diabetes.

cholesteryl ester transfer protein

CETP

phospholipid transfer protein

PLTP


Input: Two families with concordant inheritance of DNAH9 alleles in affected individuals were observed.

DNAH9 alleles


Input: Efficacy of first-generation Cavermap to verify location and function of cavernous nerves during radical prostatectomy: a multi-institutional evaluation by experienced surgeons.


Input: The (two-motif) domain fold contains a pair of calcium binding sites very similar to those found in a two-domain prokaryotic betagamma-crystallin fold family member, Protein S.

two-domain prokaryotic betagamma-crystallin fold family member

Protein S


Input: Deletional analyses of VDR indicated that GRIP1 and RAC3 required an intact VDR activation function (AF-2) domain for efficient interaction as well as additional but distinct regions of the VDR.

VDR

VDR

VDR


Input: Mechanism in the sequential control of cell morphology and S phase entry by epidermal growth factor involves distinct MEK/ERK activations.

epidermal growth factor

MEK

ERK


Input: 3D image-processing permits to analyse ultrasound data interactively in three orthogonal planes (section mode) or in realistic 3D views (rendering mode).


Input: Direct superoxide scavenging activity of nonsteroidal anti-inflammatory drugs: determination by electron spin resonance using the spin trap method.


Input: BACKGROUND: Dermoscopy is a noninvasive technique that increases the diagnostic accuracy of pigmented skin lesions, particularly improving the diagnosis of patients with cutaneous melanoma in situ (CMIS) and early invasive melanoma.


Input: Moreover, PTax expressed higher background activities than PTF, indicating that the sequence of the synthetic regulatory region can influence background levels.

PTax

PTF


Input: However, the promoter region contains several potential cis-regulatory elements such as Sp1, early growth response-1, activator protein-2, MyoD, p300, nuclear factor-kappaB, myeloid zinc finger protein-1, caudal-related homeobox (Cdx) gene A, and Cdx protein-2 binding sites.

early growth response-1

activator protein-2

MyoD

nuclear factor-kappaB

myeloid zinc finger protein-1

caudal-related homeobox (Cdx) gene A

Cdx protein-2 binding sites


Input: Thus, the interaction of Tat with the components of this rel/AP1 cooperative complex seems to induce quantitative and qualitative alterations of this complex as activation progresses, resulting in a decrease of IL-2 gene transcription.

Tat

rel

IL-2 gene


Input: Unlike other progenitor cells of the brain, SVZa progenitor cells have the capacity to divide even though they express a neuronal phenotype.


Input: A minimal ER3 sequence of DNA was further demonstrated to function as a FXR HRE and was bound in vitro by FXR-expressing yeast extracts.

FXR HRE

FXR


Input: OBJECTIVE: To determine the association of depressive symptoms with HIV-related mortality and decline in CD4 lymphocyte counts among women with HIV.


Input: An economic analysis using West of Scotland Coronary Prevention Study (WOSCOPS) findings indicates that statin treatment would have prevented 318 events per 10, 000 patients in a population similar to that in WOSCOPS (average 1. 5% annual risk of a cardiovascular event) at a discounted cost per life-year gained of 20, 375 pounds ($31, 818).

statin


Input: Furthermore, the soluble forms of ATF6 and the G13 gene product are unable to bind to several point mutants of the cis-acting ER stress response element in vitro that hardly respond to ER stress in vivo.

G13 gene product


Input: The present study was initiated to explore the potential of a hybrid biological reactor, combining trickling filter (TF) and activated sludge process (ASP), to treat wastewater containing trichloroethylene (TCE) at ambient temperature at different hydraulic retention time (HRT).


Input: In DNA strand exchange reactions using oligonucleotides, we found that Rec2 exhibited a pairing bias that is opposite that of RecA.

RecA


Input: Forskolin treatment (10 microM) of the transfected cells for 3--6 h maximally induced luciferase threefold.

luciferase


Input: Analysis of ace2Delta cells reveals that Ace2p is required for cell separation but not for polarized growth.


Input: The results presented here show that AR1 of the promoter-proximal CAP subunit was required for papBA transcription even in the absence of the histone-like protein H-NS.

CAP subunit

papBA

histone-like protein H-NS


Input: A., Slatkin, D.


Input: RESULTS: A significant correlation (p < 0. 001) was observed for mean wall thickness and vessel wall area between MRI and histopathology (r = 0. 87 and r = 0. 85, respectively).


Input: Our data indicate that SIP1 is required to confine XBra gene expression to the mesoderm.

XBra gene


Input: SIP1 (Smad interacting protein 1) and deltaEF1 (delta-crystallin enhancer binding factor) are structurally similar transcriptional repressors.

Smad interacting protein 1

delta-crystallin enhancer binding factor


Input: B-myb is essential for G1/S transition and has been shown to be phosphorylated by the cyclin A2/cdk2 complex.

B-myb

cyclin A2


Input: Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia.


Input: Human T-cell leukemia virus type I (HTLV-I) Tax is a potent transcriptional regulator that can activate or repress specific cellular genes and that has been proposed to contribute to leukemogenesis in adult T-cell leukemia.

Human T-cell leukemia virus type I (HTLV-I) Tax


Input: Requirements for the nuclear-cytoplasmic translocation of infected-cell protein 0 of herpes simplex virus 1.

infected-cell protein 0


Input: The Novacor Left Ventricular Assist System (LVAS) (Novacor Corp, Oakland, CA) was initially console-based and has been available since 1993 in a wearable configuration.


Input: Atheroma appears as a very low signal intensity area on 2-dimensional time-of-flight (TOF) magnetic resonance (MR) images, and its components have various signal intensities on spin-echo (SE) images.


Input: Body fat distribution was determined by abdominal computed tomography.


Input: The flux rates of p-toluidine decreased as the pH value in the donor solution increased.


Input: The protein is composed of two major domains separated by a hydrophobic linker region of 20 amino acid residues.


Input: We performed the present study to clarify the relationship between the DOX binding ability (% DB) and the histologic response, rate of decrease in tumor volume of malignant soft tissue tumors after preoperative chemotherapy and prognosis.


Input: To avoid misinterpretations, special reference values should be applied for preadolescents, at least with regard to FVC and FEV1.


Input: Nephrotoxicity after orthotopic liver transplantation in cyclosporin A and FK 506-treated patients.


Input: Compared with normal control subjects, all 74 TOF patients had decreased systolic and diastolic myocardial velocities and a longer isovolumic relaxation time.


Input: Acetoin can be reused by the bacteria during stationary phase when other carbon sources have been depleted.


Input: Mutational analysis showed that the U-box, like the RING finger in other proteins, forms the physical basis for the interaction with E2 enzymes.

E2 enzymes


Input: Thus, our studies define Rac/Cdc42/Pak as a module upstream of Raf-1 during its activation by microtubule disruption.

Rac

Pak


Input: Nrf2 regulates expression of genes encoding enzymes with antioxidant (e. g. heme oxygenase-1 (HO-1)) or xenobiotic detoxification (e. g.

heme oxygenase-1


Input: These results indicate that ATF4 regulates basal and CdCl (2)-induced expression of the ho-1 gene in a cell-specific manner and possibly in a complex with Nrf2.

ho-1 gene


Input: On the other hand, forced overexpression of the wild type, but not the kinase-inactivated mutant of nm23H1, converted the GDP-bound forms of Rac1, Cdc42, and RhoA to their GTP-bound forms in vitro by its nucleoside diphosphate kinase activity, but nm23H1 alone apparently did not produce the GTP-bound form of these GTPases in vivo.

RhoA

nucleoside diphosphate kinase

GTPases


Input: This effect was observed in the absence of de novo protein synthesis and was independent of histone deacetylase activity.

histone deacetylase


Input: Deletion of the potential initiator element does not affect repression of the p21 promoter by c-Myc.

p21 promoter

c-Myc


Input: Fetal lung volume: estimation at MR imaging-initial results.


Input: Of its gene products, E6 binds to and inactivates p53 tumor suppressor protein by ubiquitin/proteasome-dependent degradation.

p53 tumor suppressor protein

ubiquitin


Input: In mouse, Mmip1 (Mad member interacting protein 1) and Smc3 share 99% sequence identity and are products of the same gene.

Mad member interacting protein 1


Input: An element within the 5' untranslated region of human Hsp70 mRNA which acts as a general enhancer of mRNA translation.

human Hsp70 mRNA


Input: In SN-48 neuronal cells that express MR, GR, and 5-HT1A receptors, deletion or inactivation of the nGRE (negative GRE) eliminated negative regulation of the rat 5-HT1A or heterologous promoters by corticosteroids, whereas its inclusion conferred corticosteroid-induced inhibition to a heterologous promoter.

MR

GR

5-HT1A receptors

rat 5-HT1A


Input: Corticosteroid-mediated transcriptional inhibition was greater for MR/GR in combination than for MR or GR alone.

MR

GR

MR

GR


Input: Whereas Smad2 was rapidly phosphorylated by TGF-beta and involved in the initial activation of Agc expression in confluent cells, Smad2 activation was not required for maintaining the high level of Agc expression.

TGF-beta

Agc

Agc


Input: Reverse transcriptase-polymerase chain reaction assays showed that PKRDeltaE7 is expressed in a broad range of human tissues at variable levels.

Reverse transcriptase


Input: Both pancreatic and intestinal cell lines were found to express a number of POU (OCT binding) homeodomain proteins examined by electrophoretic mobility shift assay.

POU

OCT


Input: SV1 has a 33-amino acid insert in the S1 transmembrane domain that does not alter S1 overall hydrophobicity, but makes the S0-S1 linker longer.


Input: Polyclonal antibodies against the N-terminal part (amino acids 12-363) and the C-terminal part (amino acids 330-730) of rainbow trout HIF-1alpha protein recognized rainbow trout and chinook salmon HIF-1alpha protein in Western blot analysis.

rainbow trout HIF-1alpha protein

rainbow trout and chinook salmon HIF-1alpha protein


Input: The v-Src SH3 domain facilitates a cell adhesion-independent association with focal adhesion kinase.

v-Src SH3 domain

focal adhesion kinase


Input: Mutagenesis of SNT1 (IRS) CX identified three classes of effector motifs within SNT critical for both sustained ERK activation and neuronal differentiation: 1) four phosphotyrosine motifs that mediate recruitment of Grb2, 2) two phosphotyrosine motifs that mediate recruitment of Shp2, and 3) a C-terminal motif that functions by helping to recruit Sos.

IRS

CX

SNT

ERK

Sos


Input: Exchanging the human propeptide in this chimera with either the murine MIC-1 or TGF-beta1 propeptide resulted in secretion of the unprocessed, monomeric chimera, suggesting a specific interaction between the human MIC-1 propeptide and mature peptide.

murine MIC-1

TGF-beta1 propeptide

human MIC-1 propeptide


Input: Radiolabeled biantennary N-glycans synthesized by Pro (-) 5Lec20 were proportionately less ricin-bound than similar species from parental CHO cells, and Lec20 cell extracts had a markedly reduced ability to transfer Gal to GlcNAc-terminating acceptors.


Input: We found that the SOCS box interacted with Cullin-2 and promoted ubiquitination of TEL-JAK2.

SOCS box

TEL


Input: Neuron-specific Bcl-2 homology 3 domain-only splice variant of Bak is anti-apoptotic in neurons, but pro-apoptotic in non-neuronal cells.

Neuron-specific Bcl-2 homology 3 domain-only splice variant

Bak


Input: Sequence comparison and binding studies of the 18-bp MOK2-binding sites present in intron 2 of human, bovine, and mouse IRBP genes show that the 3'-half sequence is the essential core element for MOK2 binding.

18-bp MOK2-binding sites

mouse IRBP genes


Input: Furthermore, SB203580 inhibited LPS-induced activation of Sp1, as well as the promoter activity in cells transfected with a plasmid containing the Sp1 consensus sequence.


Input: We confirmed the interaction between TLS and p65 by the pull-down assay in vitro and by a coimmunoprecipitation experiment followed by Western blot of the cultured cell in vivo.

TLS


Input: Based on mutational data and possible mRNA structure, we hypothesized about the effect of mRNA structure on translation of the two major C/EBPepsilon isoforms: p32 and p30.

C/EBPepsilon isoforms


Input: Binding of serum response factor to CArG box sequences is necessary but not sufficient to restrict gene expression to arterial smooth muscle cells.

serum response factor


Input: Together, these results identify HPK1 as a new component of TCR signaling.

TCR


Input: The size of the infarct was determined using the creatine kinase integral method.

creatine kinase


Input: A new echocardiographic technique is described with a conventional M mode, digitalised 2D and tissular Doppler which has a comparable ability to identify the anomalous pathways of electric conduction using a non-invasive method.


Input: SELECTION CRITERIA: Randomised controlled trials of cabergoline versus placebo in patients with a clinical diagnosis of idiopathic Parkinson' s disease and long-term complications of levodopa therapy.


Input: Deterministic effects.


Input: Unusual two-domain arginine kinases (AKs) arose independently at least two times during molecular evolution of phosphagen kinases: AKs from the primitive sea anemone Anthopleurura japonicus and from the clam Pseudocardium sachalinensis.

two-domain arginine kinases

AKs

phosphagen kinases

AKs


Input: The mouse platelet-derived growth factor (PDGF) beta-receptor promoter contains a CCAAT motif, and NF-Y plays an essential role in its transcription.

mouse platelet-derived growth factor (PDGF) beta-receptor promoter

NF-Y


Input: Baseline MBF in females was significantly (P < 0. 001) higher than in males.


Input: No preferential VH/VL-chains correlated with any of the 12 different antigen reactivities, even for mAbs with nearly identical cross-reactivities.

VH

VL


Input: Recently, it was shown that purified RAG1/2 proteins can cleave DNA hairpins in vitro, but the same activity was also described for a protein complex of the DNA repair proteins Nbs1/Mre11/Rad50.

RAG1/2 proteins


Input: In addition, we did not detect significant differences in CDR3 sequences of endogenous Ig lambdaL and kappaL chain gene loci cloned from peripheral blood lymphocytes of an NBS patient and of healthy individuals.

CDR3 sequences

endogenous Ig lambdaL

kappaL chain gene loci


Input: Phase II study of paclitaxel and oral etoposide in patients with locally advanced or metastatic non-small cell lung cancer.


Input: Oral supplementation of L-arginine significantly increased plasma L-citrulline, which indicated enhancement of NO production.


Input: This activation was then blocked by CGS 12066A.


Input: Two independent transgenic lines were produced, and both showed expression of the Gus gene specifically in the endosperm during mid-development (first detected 10-12 d after anthesis).

Gus gene


Input: Here we demonstrate that native MRCK exists in high-molecular-weight complexes.

native MRCK


Input: Regression analyses showed that SOREMP dream occurrences were significantly related to the amount of REM sleep, while NREMP dream occurrences were related to arousals from NREM sleep.


Input: Instead, TRPS1 potently and specifically represses transcriptional activation mediated by other GATA factors.

GATA factors


Input: 9. 7 (95% CI: 9. 6-9. 7) micromol/L among women (P = 0. 003).


Input: Three patients received additional cycles of 5-fluorouracil +/-leucovorin as maintenance chemotherapy. RESULTS: Thirty males and 21 females with a median age of 55 years (range 31--73 years) were treated.


Input: Secretion of interleukin-8, RANTES, macrophage inflammatory protein 1alpha, and 10-kappaDa IFN-gamma-inducible protein were increased in differentiating keratinocytes by E6.

RANTES

macrophage inflammatory protein 1alpha

10-kappaDa IFN-gamma-inducible protein


Input: Another mutant, T255A, lost the ability to bind E4orf6, but unexpectedly, viral late-gene expression was not affected.


Input: Herein PPARgamma, liganded by either natural (15d-PGJ (2) and PGD (2)) or synthetic ligands (BRL49653 and troglitazone), selectively inhibited expression of the cyclin D1 gene.

PPARgamma

cyclin D1 gene


Input: Here we demonstrate that the Ras-activated Raf-MEK-extracellular signal-regulated kinase (ERK) signaling pathway can specifically control the expression of individual integrin subunits in a variety of human and mouse cell lines.

Ras

Raf

MEK

extracellular signal-regulated kinase

ERK

integrin subunits


Input: Children who developed lower respiratory tract infections or PCP had increased rates of decline of CD4 cell counts during the first 6 months of life.


Input: The reproductive effects of the administration of 4-chloro-2-methylphenoxyacetic acid (MCPA) to rats were evaluated through two generations, from prior to mating, throughout mating, to gestation and lactation.


Input: Coexposure to FP also resulted in a more pronounced and sustained activation of the mitogen-activated protein kinase kinase/extracellular signal-regulated protein kinase cascade after PMA treatment, although disruption of this pathway by the mitogen-activated protein kinase kinase 1 inhibitor U0126 did not prevent potentiation of apoptosis.

mitogen-activated protein kinase kinase

extracellular signal-regulated protein kinase

mitogen-activated protein kinase kinase 1


Input: Also, the EWS protein stimulates transcription mediated by the COOH-terminal transactivation domain of the cofactor CREB-binding protein (CBP).

EWS protein

CREB-binding protein

CBP


Input: In the present study, we have determined the ICBP90 gene structure by screening of a human placenta genomic library and PCR analysis.

ICBP90 gene


Input: Tumor-like accumulation on Tl-201 SPECT in subacute hemorrhagic cerebral infarction.


Input: METHODS: 126 patients with histologically confirmed MFH were analyzed.


Input: It is surprising that dnaE173, a potent mutator mutation specific for sequence substitution as well as single-base frameshift, did not enhance the frequency of the hot-spot frameshift mutation.


Input: Its transcription in vitro by pol III requires the same factors as the U6 gene with the major exception that the modified TATA-box of this construct only interacts with a TATA-binding protein (TBP) mutant (TBP-DR2) but not with TBP wild-type (TBPwt).

pol III

U6 gene

TATA-binding protein

TBP

TBP wild-type

TBPwt


Input: HSF binds DNA as a trimer, and additional trimers can bind DNA co-operatively.

HSF


Input: We also demonstrate that the spo20 (+) gene product is structurally homologous to Saccharomyces cerevisiae Sec14, the major phosphatidylinositol transfer protein of budding yeast.

spo20 (+) gene product

Saccharomyces cerevisiae Sec14


Input: There was no evidence of linkage disequilibrium between the polymorphic site in the B cell specific promoter and those in the 3' UTR.


Input: Their numbers have regularly increased since the mid-1970s.


Input: Specimen mass reduction increased with irradiance from 19 to 72% of the initial mass for 9--31 W/cm (2), respectively.


Input: In conclusion, tube size estimated by Cole' s formula tends to be smaller than practically appropriate tube size for pediatric cardiac anesthesia, and therefore we suggest new formula to estimate the tube size.


Input: An F222W: W21F rGST A1-1 double mutant provides a direct fluorescence probe of changes in the environment of the C-terminal residue.

F222W: W21F rGST A1-1 double mutant


Input: The recessive hos1 mutation causes enhanced induction of the CBF transcription factors by low temperature as well as of their downstream cold-responsive genes.

CBF transcription factors


Input: Stable transfection of human CHOP cDNA into mammary carcinoma cells demonstrated that CHOP functioned not as a mediator of hGH-stimulated mitogenesis but rather enhanced the protection from apoptosis afforded by hGH in a p38 MAPK-dependent manner.

human CHOP cDNA

CHOP

hGH

hGH


Input: A comparison of the duplicated Vkappa genes suggests positive selection on the complementarity-determining regions of the duplicated genes by point mutations.

Vkappa genes


Input: In contrast, the ubiquitous expression of p19 (INK4d) has not been previously described in human or murine B-lineage cells.


Input: The results show that cognitive stimulation enhanced performance on the Boston Naming Test and a Word List Recognition Task; physical intervention, however, did not reach statistical significance.


Input: Instead, affective flattening was associated with both dopamine receptor sensitivity and psychomotor slowing.

dopamine receptor


Input: Homo-oligomerisation and nuclear localisation of mouse histone deacetylase 1.

mouse histone deacetylase 1


Input: With NEU overexpression, nodal control decreased from 72% to 34% (p =. 008).

NEU


Input: At the time of the blind therapeutic doses, Tg-off values ranged from 8 to 608 microg/l.

Tg


Input: Effects of a booster dose of tetanus toxoid after different primary courses of vaccination: implications on the use of immune globulin.

immune globulin


Input: Using RACE techniques we have cloned and sequenced one of the hamster liver 3-hydroxy-hexobarbital dehydrogenases which catalyze not only cyclic alcohols but also 17beta-hydroxy-steroids and 3alpha-hydroxysteroids.

3-hydroxy-hexobarbital dehydrogenases


Input: An association was demonstrated between the expression of aberrantly and/or alternatively spliced mdm2 mRNAs and a lack of progesterone receptor.

mdm2 mRNAs

progesterone receptor


Input: Histological examination showed lichenoid changes, acantholytic blister formation and apoptotic keratinocytes.


Input: We find that our response function is well approximated by the GSER only within a particular frequency range determined by the material parameters of both the bead and the network.


Input: It is shown that, for any periodic input, the map representing the relation between input phases at consecutive discharge times can be restricted to a piecewise continuous, orientation preserving circle map.


Input: Nine strains were subtyped as Camp. jejuni subsp. jejuni biotype II and the remaining ones as biotype I.


Input: Analysis of mCTR mRNAs has revealed that the three alternative promoters give rise to at least seven mCTR isoforms in the 5' region of the gene and generate 5'-untranslated regions of very different lengths.

mCTR mRNAs

mCTR isoforms


Input: Effects of 3' terminus modifications on mRNA functional decay during in vitro protein synthesis.


Input: A comprehensive neuropsychological battery was administered to 48 veterans with Gulf War Illness (GWI) characterized by severe fatigue (GV-F) and 39 healthy veterans (GV-H).


Input: Reverse transcription-PCR analysis of mRNA from patients shows that each of these five mutations results in aberrant splicing.


Input: RESULTS: Coronary mortality during the median follow-up time of 17 months was 6-fold higher in the highest tertile for CRP and IL-6 and 3. 5-fold higher in the highest tertile for fibrinogen and TNF-alpha than in the respective combined lower tertiles.

CRP

fibrinogen

TNF-alpha


Input: The relationship of the factor V Leiden mutation or the deletion-deletion polymorphism of the angiotensin converting enzyme to postoperative thromboembolic events following total joint arthroplasty.

factor V Leiden mutation

angiotensin converting enzyme


Input: To examine transcriptional regulation of the rat eIF4E gene, 2. 1 kB of the rat eIF4E promoter region was cloned and the contribution of specific elements in regulating transcription was determined in primary cultures of rat cardiocytes and in a murine C (2) C (12) myoblast cell line.

rat eIF4E gene

rat eIF4E promoter region


Input: In the remaining case, the aneurysm originated from the proximal end of the associated A1 fenestration.


Input: GABA (B) R1g was expressed in both brain and peripheral tissues.

GABA (B) R1g


Input: Raes, P.


Input: NF-kappaB pathway activation occurs during transformation induced by a number of classical oncogenes, including Bcr/Abl, Ras and Rac, and is necessary for full transforming potential.

NF-kappaB

Bcr

Abl

Ras

Rac


Input: We used a rev-and RRE-defective HIV type 1 (HIV-1) molecular clone in complementation experiments to establish a method for the rapid isolation of posttranscriptional regulatory elements from the mammalian genome by selecting for rescue of virus replication.

rev

RRE


Input: Copyright 2001 Academic Press.


Input: A novel myeloid-restricted zebrafish CCAAT/enhancer-binding protein with a potent transcriptional activation domain.

CCAAT/enhancer-binding protein


Input: Recently, we discovered that alanine substitutions of the active center cleft residues significantly impair the depurinating and ribosome inhibitory activity of PAP.

PAP


Input: SH2D1A protein levels are up-regulated by CD40 cross-linking and down-regulated by B cell receptor ligation.

SH2D1A protein

B cell receptor


Input: Cross-linking FcalphaR on wt-ITAM or IIA-ITAM cells triggered equivalent PI 3-kinase-dependent activation of PKBalpha.

FcalphaR

wt-ITAM

IIA-ITAM

PI 3-kinase

PKBalpha


Input: RPM/RGL3 resembled AF-6 and Nore1 in interacting strongly with constitutively active M-Ras and p21 Ras.

RPM

M-Ras

p21 Ras


Input: A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.

M-Ras

p21 Ras

p21 Ras


Input: The mice are phenotypically normal and do not develop spontaneous tumors at an early age, in contrast to knock-out (p53 (-/-)) strains with a defective p53 gene.

p53 (-/-)

p53 gene


Input: Cyclins are one of the pivotal determinants regulating cell cycle progression.

Cyclins


Input: Evidence-based care: a new formula for an old problem?


Input: Further, the osteo-retentive ability of the hydroxyapatite in the sockets was seen to be close to significance (after six months width differences, in the canine region: P = 0. 059, LHS, and P = 0. 065, RHS).


Input: The cleavage site between VPg and RNA dependent RNA polymerase was predicted to be E445-T446 based on the amino acid sequence analysis of the polyprotein from different sobemoviruses.

VPg

RNA dependent RNA polymerase


Input: The% SVend of HCM-I was significantly lower than the respective values of the HCM-II and Control groups.


Input: Nearly all isolates of S. intermedius and most isolates of S. constellatus, but only 19% of those of S. anginosus, were associated with abscess.


Input: DESIGN: Retrospective study.


Input: Human brain cDNA library screening and 5' rapid amplification of cDNA ends yielded full-length DENTT cDNA containing an 1899-bp open reading frame encoding a predicted 633-amino-acid protein with four potential nuclear localization signals (NLSs) and two coiled-coil regions.

full-length DENTT cDNA


Input: Transfection of EGFP-tagged DENTT NLS deletion constructs lacking the bipartite NLS-1 were excluded from the nucleolus.

EGFP

DENTT


Input: These genes encode a tryptophanyl tRNA, the protein translocase component SecE, the antiterminator protein NusG, and the ribosomal proteins L11 and L1 in addition to PkwR, a putative regulatory protein of the LacI-GalR family.

tryptophanyl tRNA

protein translocase

SecE

antiterminator protein NusG

PkwR

LacI

GalR


Input: Rapamycin (FRAP/mTOR inhibitor) blocked 4E-BP1 phosphorylation causing a predominance of the alpha (hypophosphorylated) band.

FRAP

mTOR


Input: Sixteen out of 52 seropositive MS patients (30. 8%) showed intrathecal synthesis of C. pneumoniae-specific IgG but only one of 43 seropositive controls (2. 3%).

C. pneumoniae-specific IgG


Input: Far Western blot analysis suggested that the tandem SH2 domains of SHP2 bind to Gab1 in a specific orientation, in which the N-SH2 domain binds to phosphotyrosine (Tyr (P))-627 and the C-SH2 domain binds to Tyr (P)-659.

SH2 domains

N-SH2 domain

C-SH2 domain


Input: Molecular cloning, genomic mapping, and expression of two secretor blood group alpha (1, 2) fucosyltransferase genes differentially regulated in mouse uterine epithelium and gastrointestinal tract.

secretor blood group alpha (1, 2) fucosyltransferase genes


Input: The UBA domains of RAD23 and DDI1 are required for these interactions.

UBA domains


Input: It was found that intrathecal administration (i. t.) of D2 receptor agonist LY171555 or D1/D2 receptor agonist apomorphine increased pain threshold and had a potentiating effect on AA.

D2 receptor

D1/D2 receptor


Input: The R2 between MFI of fresh and frozen muscle was 0. 94 and 0. 92 for lamb and pork longissimus, respectively.


Input: After all doses of d-amphetamine, responding occurred largely on the saline key under both schedules.


Input: Intravenous L-carnitine treatment increased plasma carnitine concentrations, improved patient-assessed fatigue, and may prevent the decline in peak exercise capacity in hemodialysis patients.


Input: Elevated expression of full-length UhpB or of a soluble hybrid protein, GST-Bc, which is glutathione S-transferase (GST) fused to the cytoplasmic C-terminal portion of UhpB, results in complete blockage of uhpT expression in a uhp (+) strain.

full-length UhpB

GST

Bc

glutathione S-transferase

GST

UhpB

uhpT

uhp (+)


Input: Here we show that PKC and p44/p42MAPK signalings are required for the HBx-induced Sp1-mediated IGF-II P4 transcriptional activity since (i) PKC activation by PMA or PKC expression vector increases Sp1 phosphorylation and P4 activity in HBx-transfected HepG2 cells; (ii) PKC inhibition by PKC inhibitor Go6976 reduces Sp1 phosphorylation, P4 activity, and IGF-II mRNA in HBx-transfected HepG2 cells; and (iii) the inhibition of MEK activation by U0126 reduces Sp1 phosphorylation, P4 activity and IGF-II mRNA in HBx-transfected HepG2 cells.

PKC

HBx

IGF-II P4

PKC

PKC

HBx

PKC

PKC

IGF-II mRNA

HBx

MEK

IGF-II mRNA

HBx