Input: The clinical stage was I (T1N0M0), and S2 sleeve segmentectomy with lymph node dissection (R 2 b) was performed.


Input: Benztropine for venlafaxine-induced night sweats.


Input: The physicians in charge of all patients with evidence of acute Q fever (seroconversion and/or presence of IgM) or chronic Q fever (prolonged disease and/or IgG antibody titer to phase I of Coxiella burnetii > or = 800) were asked to complete a questionnaire, which was computerized.

IgM

IgG antibody


Input: Copyright 2000 Academic Press.


Input: Viral cell-to-cell movement of PVX CP mutant was complemented in Nicotiana tabacum cv.

PVX CP mutant


Input: Induction of CD86 expression by stimulation of U937 cells with IFN-gamma revealed the presence of two functional GAS (gamma-interferon activation site) elements.

IFN-gamma

GAS

gamma-interferon activation site


Input: SNAP-23 plays an important role in the regulation of vesicle trafficking in mammalian cells.


Input: Ab-MLV strains expressing P70/S2 failed to transform NIH 3T3 cells and demonstrated a greatly reduced capacity to mediate signaling events associated with the Ras-dependent mitogen-activated protein (MAP) kinase pathway.

Ras

mitogen-activated protein (MAP) kinase


Input: The p53-homolog p73beta also activated the PIG3 promoter, but in contrast to p53, the proline-rich domain of p73beta (residues 81-113) was dispensable to induce the PIG3 promoter.

p53-homolog p73beta

PIG3 promoter

p73beta (residues 81-113)

PIG3 promoter


Input: Results from transient assays using these mutants showed that the DE1 received signals from phytochromes A and B, demonstrating that this element is indeed a light-responsive element.

phytochromes A and B


Input: Co-immunoprecipitation and DNA affinity chromatography prove that Sp1 heterodimerizes with ZBP-89 when bound to the silencer element to yield a DNA-protein complex whose mobility is indistinguishable from that displayed by HeLa nuclear extract in band shift assays.


Input: The ZNF274 gene is mapped distal to marker RP S28 1 in the human chromosome 19qter region, by RH mapping.

ZNF274 gene


Input: The C-terminal Cdk2 truncations, however, were non-functional in these strains and thus dependent for activity on the pho85 coding region which remained in the mutant pho85:: HIS3 chromosomal locus.

C-terminal Cdk2

pho85 coding region

mutant pho85

HIS3 chromosomal locus


Input: We report here on the molecular nature of an EMS-induced mutant, mn1-89, a leaky semidominant allele of the Miniature1 (Mn1) seed locus that encodes a seed-specific cell wall invertase, INCW2.

seed-specific cell wall invertase


Input: We conclude that, both in atrial myocytes and in Xenopus oocytes, beta-adrenergic stimulation potentiates the ACh-evoked GIRK channels via a pathway that involves PKA-catalyzed phosphorylation downstream from beta (2) AR.

GIRK channels

PKA

beta (2) AR


Input: Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins.

E2F3 product

Rb proteins


Input: In DNase I footprinting protection analysis, both SFRE and ERE regions were protected by glutathione S-transferase-ERRalpha1 fusion protein.

DNase I

SFRE

glutathione S-transferase


Input: Overexpressing the coactivator, SRC1a or GRIP1, further enhances ERRalpha1-induced transcriptional activity.


Input: Estrogen receptor-related receptor alpha 1 interacts with coactivator and constitutively activates the estrogen response elements of the human lactoferrin gene.

Estrogen receptor-related receptor alpha 1

human lactoferrin gene


Input: The median levels of particles with 50% cut-off aerodynamic diameters of 10 (PM10) and 2. 5 microm (PM2. 5) were 170 (range 103-613) and 95 (range 61-218) micro x m-3, respectively.


Input: Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana.


Input: Comparison of sequences from-215 to + 1 bp identified consensus binding sites for the homeodomain transcription factor thyroid transcription factor-1 (TTF-1).

homeodomain transcription factor thyroid transcription factor-1


Input: Two additional cis-acting sequences, conserved in both the region 1 and 3 promoters, were identified, suggesting a role for these sequences in the coordinate regulation of transcription from these promoters.


Input: Purple photosynthetic bacteria are capable of generating cellular energy from several sources, including photosynthesis, respiration, and H (2) oxidation.


Input: An analysis of synthetic peptides revealed a minimal CTD sequence that is sufficient to bind to the second Rsp5 WW domain (Rsp5 WW2) in vitro and in yeast two-hybrid assays.

Rsp5 WW domain

Rsp5 WW2


Input: Furthermore, bone marrow-derived macrophages from LAT-deficient mice displayed reduced phagocytic efficiency in comparison to the macrophages from wild-type mice.

LAT


Input: T1-weighted MRI on the 49th postoperative day demonstrated bilateral and symmetrical hyperintense lesions in the globus pallidus.


Input: The method is applied to determine aberration constants of a CM300 FEG/UT microscope with correction of the three-fold astigmatism.


Input: The interaction does not depend on the presence of the correct amino-terminal DNA binding domain or the amino acid sequences between the DNA binding domain and the last ten amino acids.


Input: METHOD: The sample of subjects was drawn from the Suffolk County Mental Health Project, a longitudinal epidemiologic study of first-hospitalized subjects with psychotic disorders; the present study focused on patients with schizophrenic disorders.


Input: Marrow dysplasia is a major characteristic of patients with myelodysplastic syndrome (MDS), along with marrow blastosis, cytopenia and cytogenetic anomalies.


Input: Eight of the non-acceptable inlays/onlays and five of the direct restorations were replaced, while the other ones were repaired with resin composite.


Input: How plants respond to attack by the range of herbivores and pathogens that confront them in the field is the subject of considerable research by both molecular biologists and ecologists.


Input: CONCLUSION: The probability of cardiopulmonary complications increases significantly when patients develop class 1 HELLP syndrome.


Input: The rate-limiting step for telomerase activity seems to be the expression of the catalytic subunit of the enzyme, encoded by the human telomerase reverse transcriptase (hTERT) gene.

telomerase

human telomerase reverse transcriptase

hTERT


Input: In the control group, platelet markers increased 1 h after surgery.


Input: However, the element proximal to the transcription start site is dependent on the SRE-1.


Input: Since proteins containing TPR elements are typically involved in multiple protein-protein interactions, we suggest that the 102kD protein interacts within the tri-snRNP with both the U5 and U4/U6 snRNPs, thus bridging the two particles.


Input: Antibodies raised against a C-terminal portion of Sec31A co-precipitate Sec13 and inhibit ER-Golgi transport of temperature-arrested vesicular stomatitis G protein in a semi-intact cell assay.

stomatitis G protein


Input: Regulation of mitochondrial single-stranded DNA-binding protein gene expression links nuclear and mitochondrial DNA replication in drosophila.


Input: Genetic and molecular complexity of the position effect variegation modifier mod (mdg4) in Drosophila. mod (mdg4), also known as E (var) 3-93D, is involved in a variety of processes, such as gene silencing in position effect variegation (PEV), the control of gypsy insulator sequences, regulation of homeotic gene expression, and programmed cell death.

modifier

mod

E (var) 3-93D

gypsy insulator sequences

homeotic gene


Input: They are present in many kinds of living things, but their functions, especially those in humans, are unclear.


Input: This tendency is likely due to the biased nucleotide composition of the asparagus genome, rather than to the translational selection for specific codons.


Input: Transduction of the human leukemic cell line K562 showed that viral MRP1-PG13 supernatants routinely transfer the MRP1 gene to approximately 35% of target K562 cells, of which at least one third are capable of proliferating in the presence of otherwise toxic concentrations of etoposide.

MRP1 gene


Input: Regulation of pituitary vasopressin V1b receptors plays a critical role in regulating pituitary adrenocorticotropic hormone (ACTH) secretion during adaptation to stress.

vasopressin V1b receptors

pituitary adrenocorticotropic hormone

ACTH


Input: Identification of an AfsA homologue (BarX) from Streptomyces virginiae as a pleiotropic regulator controlling autoregulator biosynthesis, virginiamycin biosynthesis and virginiamycin M1 resistance.

AfsA homologue

BarX


Input: Given its relative longevity on the Web, TIE researchers have been in a unique position to observe trends in telemedicine.


Input: Cerebral vasculitis secondary to Crohn' s disease seems to be a very rare phenomenon.


Input: To test the hypothesis that progestin-mediated increases in resting core temperature and the core temperature threshold for sweating onset are counteracted by estrogen, we studied eight women (24 +/-2 yr) at 27 degrees C rest, during 20 min of passive heating (35 degrees C), and during 40 min of exercise at 35 degrees C.


Input: Our data show also that phagocytic killing of meningococci is probably a more consistent assay than antibody titer levels for antimeningococcal immunity, especially in LCC-deficient patients.


Input: These studies suggest an additional component or cellular environment is required for SPRK activation by Cdc42.

SPRK


Input: M.


Input: Jkappa DNA-binding sites were not required for this activation, and a mutant EBNA-3C protein unable to bind Jkappa activated transcription as efficiently as wild-type EBNA-3C, indicating that EBNA-3C can regulate transcription through a mechanism that is independent of Jkappa.

Jkappa DNA-binding sites

mutant EBNA-3C protein

Jkappa

wild-type EBNA-3C

Jkappa


Input: Thus, both YY1 and CDP appear to be negative regulators of the differentiation-induced HPV-6 E1 promoter and thereby the HPV life cycle.

CDP

HPV-6 E1 promoter


Input: Sequential cleavage by metallopeptidases and proteasomes is involved in processing HIV-1 ENV epitope for endogenous MHC class I antigen presentation.

metallopeptidases

HIV-1 ENV epitope

MHC class I antigen


Input: Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation.

human Lnk

pleckstrin

Src homology 2 domains


Input: Vancomycin data were analyzed according to a one-compartment open model with use of NONMEM population pharmacokinetic software.


Input: Finally, Cas existed mainly in cytosol and membrane cytoskeleton fractions in the resting state, and remained unchanged during platelet aggregation, when FAK translocated to the cytoskeletal fraction.

Cas

FAK


Input: Transcriptional regulation of the yeast PHO8 promoter in comparison to the coregulated PHO5 promoter.

yeast PHO8 promoter

PHO5 promoter


Input: The Siglecs are a subfamily of I-type lectins (immunoglobulin superfamily proteins that bind sugars) that specifically recognize sialic acids.

Siglecs

I-type lectins

immunoglobulin superfamily proteins


Input: Our data provide a biochemical explanation for the similarity in phenotype between A-T and NBS.


Input: PATIENTS OR OTHER PARTICIPANTS: Twenty children met the criteria for being learning disabled.


Input: Update on maternal-fetal infections by hepatitis C, HIV and cytomegalovirus


Input: In the present study, we characterized cis-elements of the human PCI gene required for expression in the hepatoma-derived cell line, HepG2 cells, and also evaluated rat PCI mRNA expression, particularly on the effect of androgen in rat reproductive tissues.

human PCI gene

rat PCI mRNA


Input: In the study on PCI mRNA expression in the reproductive organs, we first cloned rat PCI cDNA and then evaluated the effect of androgen on the PCI mRNA expression.

PCI mRNA

rat PCI cDNA

PCI mRNA


Input: The stoichiometry of the complexes formed with the dodeca-satellite C strand suggests that, in DDP1, the 15 consecutive KH domains are organized such that they define two nucleic acid binding surfaces.


Input: Mutational analysis of mammalian translation initiation factor 5 (eIF5): role of interaction between the beta subunit of eIF2 and eIF5 in eIF5 function in vitro and in vivo.

mammalian translation initiation factor 5


Input: Much evidence indicates that p38 is an activator of MyoD: (i) p38 kinase activity is required for the expression of MyoD-responsive genes, (ii) enforced induction of p38 stimulates the transcriptional activity of a Gal4-MyoD fusion protein and allows efficient activation of chromatin-integrated reporters by MyoD, and (iii) MyoD-dependent myogenic conversion is reduced in mouse embryonic fibroblasts derived from p38alpha (-/-) embryos.

MyoD

p38 kinase

MyoD

MyoD

MyoD

MyoD

p38alpha (-/-)


Input: This activity is stimulated by complex formation with the other eIF2B subunits.

eIF2B subunits


Input: Our analysis of nonsense mutations indicates that the C terminus of eIF2Bepsilon (residues 518 to 712) is required for both catalytic activity and interaction with eIF2.

eIF2Bepsilon (residues 518 to 712)


Input: In contrast, mutations affecting the other two Nim1p-related kinases in S. cerevisiae, Hsl1p and Kcc4p, produce no detectable effect on septin organization.

Nim1p-related kinases

septin


Input: CONCLUSIONS: Physiologic pacing provides little benefit over ventricular pacing for the prevention of stroke or death due to cardiovascular causes.


Input: Among non-cirrhotics, lack of portal vein visualisation had a 90% sensitivity, 88% specificity, 94% negative predictive value, and 83% positive predictive value in the diagnosis of pre-sinusoidal portal hypertension.


Input: The serine-threonine kinase gene is likely functional, whereas the zinc finger motif is likely nonfunctional.

serine-threonine kinase gene


Input: Stat activation in response to GH and IL-6 was determined by reporter gene induction.

Stat

GH


Input: HFA 134a had a greater tendency to take up moisture from the environment than did HFA 227.


Input: RESULTS: Abnormal color perception was found in 32% of the epilepsy patients treated with vigabatrin monotherapy and 28% of the epilepsy patients treated with carbamazepine monotherapy.


Input: In the SPP2 screening test, a few plates were not seen in both groups.


Input: Mitogen-activated protein (MAP) kinase phosphatase-3 (MKP-3) is a dual specificity phosphatase that inactivates extracellular signal-regulated kinase (ERK) MAP kinases.

Mitogen-activated protein (MAP) kinase phosphatase-3

extracellular signal-regulated kinase

ERK

MAP kinases


Input: Consistent with this, we show that peptides representing docking sites within the target substrates Elk-1 and p90 (rsk) inhibit ERK-dependent activation of MKP-3.

rsk

ERK


Input: HPLC phosphopeptide mapping, amino acid sequencing, and site-directed mutagenesis determined that NCLK phosphorylates Ser (67) of I-1.

NCLK


Input: When the entire diet consisted of SBF, voluntary feed intake was reduced, indicating that SBF should not be fed to ponies as the sole dietary ingredient.


Input: Hepatitis C virus infection and lymphoproliferative diseases in France: a national study.


Input: Interestingly, a decreased transcription from the endogenous c-Myb promoter was observed in several HTLV-I transformed T-cell lines.

c-Myb promoter


Input: H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19.


Input: C. elegans KLP-11/OSM-3/KAP-1: orthologs of the sea urchin kinesin-II, and mouse KIF3A/KIFB/KAP3 kinesin complexes.

sea urchin kinesin-II

KIFB

KAP3 kinesin


Input: BACKGROUND: Hepatic encephalopathy is a neuropsychiatric syndrome associated with acute liver failure, chronic parenchymal liver disease or portal systemic anastomosis.


Input: These natural antisense S transcripts co-exist with several less abundant sense S transcripts.

S transcripts

S transcripts


Input: Nor is such adjustment possible unless one posits a model that relates the missing observations to other observed information for each subject-models that are inherently untestable.


Input: However, the presence of effacement seems to be a more reliable and practical parameter that will be preferred in that prediction.


Input: The data are compatible with the idea that YLL031c transfers the ethanolaminephosphate to the inner alpha1-2-linked mannose, i. e. the group that links the GPI lipid anchor to proteins, whereas Mcd4p and Gpi7p transfer ethanolaminephosphate onto the alpha1-4-and alpha1-6-linked mannoses of the GPI anchor, respectively.


Input: The C terminus of TRBP binds to CBP/p300 and DRIP130, a component of the DRIP/TRAP/ARC complex, which suggests that TRBP may activate transcription by means of such interactions.

TRBP

CBP

DRIP

TRAP

ARC

TRBP


Input: The patients who presented with mucocutaneous disease also had low CD4 + T lymphocyte counts, and most of them had AIDS defining illnesses.

CD4 +


Input: Increased dietary energy decreased PAB and the use of added dietary CO rather than PF decreased PSHL in broiler breeders between 26 and 47 wk of age.


Input: The gene amplification model of Coquelle et al.


Input: Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation.

protein tyrosine kinases

syk

Syk

Lck

STAT


Input: Immobilized dimers of N-cadherin-Fc chimera mimic cadherin-mediated cell contact formation: contribution of both outside-in and inside-out signals.

N-cadherin

Fc


Input: The monoclonal immunoglobulin products of plasma cell neoplasm can give rise to a variety of manifestations including hyperviscosity, amyloidosis, cryoglobulinemia, neuropathy, and renal failure.

immunoglobulin


Input: Investigation of the structural basis of the interaction between human Igs and gp120 shows that the viral gp120 SAg can interact only with a subset of human V (H) 3 + Igs.

human Igs

viral gp120 SAg

human V (H) 3 + Igs


Input: Double-blind, placebo-controlled trial.


Input: Here, it is shown that TAFII250, the largest subunit of TFIID, contains two tandem bromodomain modules that bind selectively to multiply acetylated histone H4 peptides.

TFIID

histone H4 peptides


Input: Endostatin treatment for 10 minutes or 24 hours induced tyrosine phosphorylation of Shb and formation of multiprotein complexes.

Shb


Input: The transcript was initially identified as a partial cDNA sequence in the course of constructing a transcript map of the region between markers D11S1765 and uteroglobin known to encompass the gene causing Best disease.

uteroglobin


Input: The real challenge for the future will be the management of patients who do not respond to first-line treatment.


Input: Iodine deficiency disorders in Bangladesh.


Input: RESULTS: Soluble CD23 levels were significantly higher in women with endometriosis before treatment than in ten normal controls.


Input: CONCLUSION: Our findings suggest that endometriosis increases soluble CD23 levels, which can be suppressed with either danazol or leuprolide acetate injection.


Input: To isolate this gene, a P-1 artificial chromosome (PAC) library was screened with a full length UGT2B7 probe and a clone of approximately 100 kb in length was isolated.

full length UGT2B7


Input: Age >/= 50 years (odds ratio [OR], 14. 1), BMI >/= 28 kg/m (2) (OR, 5. 7), triglycerides >/= 1. 7 mmol/L (OR, 5), and alanine aminotransferase (ALT) >/= 2N (OR, 4. 6) were independently associated with septal fibrosis.

alanine aminotransferase

ALT


Input: However, the elderly group showed significantly longer mean residence times (MRTs) and lower plasma clearance of lidocaine during the period compared with the adult group (P <. 05).


Input: Here, we show that the zinc finger protein Gis1 acts as a dosage-dependent suppressor of the rim15Delta defect in nutrient limitation-induced transcriptional derepression of SSA3.

zinc finger protein Gis1


Input: The so-called " SH3 " segment of the linker domain, in contrast, shows species-specific sequence identity in all but one amino acid residues in both factors, in cattle, human, and mouse.

" SH3 " segment


Input: No differences in total cholesterol levels were observed between mapuches and aymaras.


Input: Up to 95% of the total UV exposure received is in the UV-A waveband (320-400 nm).


Input: To begin to characterize the role of the RNA subunits in enzyme function and substrate specificity, we swapped two hairpin structures (MRP3 and P3) between RNase MRP RNA and RNase P RNA of S. cerevisiae.

RNase MRP RNA

RNase P RNA of S. cerevisiae


Input: Among genes induced by added pMesogenin1 is Xwnt-8, a signaling factor that induces a similar repertoire of marker genes and a similar cellular phenotype.


Input: Accordingly, no Ha-ras codon 12 mutations are found in the EtNU-induced mammary tumors.

Ha-ras codon 12


Input: False positive PET FDG corresponded to lung infection, degenerative bone disease, and reconstruction artifact.


Input: Tumor stages were IIB (T3 N0) in 52%, IIIA in 15%, and IIIB in 27% of patients.


Input: Similarly, comparison of percentage reductions of heart rate at supine, sitting and exercise by repeated measure analysis showed the Malays to have significantly higher change compared to the Chinese (p = 0. 040).


Input: Consistent with our model, CTCF binding is abolished by DNA methylation.

CTCF


Input: OBJECTIVE: To determine the efficacy and safety of amphotericin B oral suspension (ABOS) for the treatment of fluconazole refractory oral candidiasis in persons with HIV infection.


Input: The experimentally mapped regions of RPB5 involved in these interactions correspond to distinct and surface-exposed alpha-helical structures.


Input: The model indicates that a 0. 076% reduction in cigarette consumption is associated with the availability of nicotine patches after 1992.


Input: Paper alert.


Input: The tryptase locus also contains at least four tryptase-like pseudogenes, including mastin, a gene expressed in dogs but not in humans.

tryptase locus

tryptase-like pseudogenes

mastin


Input: The cellular part of the third chimeric clone shows significant homology to an exon of the human tyrosine phosphatase 1 gene, although oriented in the antisense direction compared to the adjacent LTR.

human tyrosine phosphatase 1 gene


Input: OBJECTIVE: This study was conducted to assess the relative roles of 99mTc-sestamibi scintimammography and sonography in the evaluation of breast lesions that are indeterminate or suspicious on mammography or clinical examination.


Input: Mutational analyses showed that in-frame stop codons introduced into five of seven RNA 2 ORFs did not affect accumulation of progeny LIYV RNA 1 or RNA 2, confirming that RNA 2 does not encode proteins necessary for LIYV RNA replication.

RNA 2 ORFs

LIYV RNA 1

RNA 2

RNA 2


Input: Role of NH (2)-and COOH-terminal domains of the P protein of human parainfluenza virus type 3 in transcription and replication.

P protein


Input: Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors.

Eph receptors


Input: RESULTS: Fournier' s gangrene occurs worldwide.


Input: Genomic DNA sequencing in the vicinity of methylmalonyl-CoA mutase gene (mutAB) from a rifamycin SV-producing Amycolatopsis mediterranei U32 allowed us to clone, sequence, and identify a gene encoding a novel serine/threonine protein kinase (amk).

methylmalonyl-CoA mutase gene

mutAB

serine/threonine protein kinase

amk


Input: IL-2 is accepted as a standard treatment used alone, or in combination with chemotherapy or biotherapy in the management of metastatic melanoma and metastatic renal cell carcinoma.


Input: Moreover, expression of antisense Ha-Ras or dominant negative Raf-1 abrogated the mitogenic effect of TGF-beta1 in TSU-Pr1, and the TGF-beta1 inhibition of DU145 was switched to stimulation by V12Ha-Ras transfection.

antisense Ha-Ras

dominant negative Raf-1


Input: Taken together, our data suggest that prostate carcinomas with the Ras/MAPK pathway activation might have a selective growth advantage by autocrine TGF-beta1 production.

Ras

MAPK


Input: Vbeta segments are appended to DJbeta rearrangements, with little or no direct Vbeta to Jbeta joining, despite 12/23 compatibility of Vbeta 23-RSSs and Jbeta12-RSSs.

Vbeta

DJbeta

Vbeta

Jbeta

Vbeta 23-RSSs


Input: For oral administration, AUC0-infinity was 58. 47 +/-16. 37 microg x h/ml, t1/2beta was 18. 39 +/-0. 06 hours, maximum concentration (Cmax) was 2. 12 +/-00. 51 microg/ml, time to Cmax was 2. 20 +/-2. 17 hours, mean absorption time was 2. 09 +/-0. 51 hours, and bioavailability was 42 +/-0. 42%.


Input: In experiment 2, no difference in gastric emptying of 40% peptone or 25% glucose was found between rats receiving TPN and those receiving intragastric nutrition for 10 to 12 days.


Input: In contrast, H-NS negative regulation operated only in the absence of Fur.

H-NS

Fur


Input: Thus, SAG appears to control cell cycle progression in yeast by promoting ubiquitination and degradation of cell cycle regulatory proteins.

SAG


Input: It brings about fatigue, negative moods, and impaired health, sleep, safety, and working capacity.


Input: This demonstrates that treatment of the graft recipient for a relatively short period during and after surgery has a favorable effect on the survival of grafted dopaminergic neurons.


Input: The relationships among blood concentrations of thyroid hormones and selenium, zinc, retinol, and alpha-tocopherol were studied in 44 healthy Northern Italian oldest-old subjects (age range, 90-107 yr), selected by the criteria of the SENIEUR protocol.


Input: Chinese Spring (CS) carrying the Q gene to those of a chromosome deletion line of CS, namely, q5, which lacks 15% of 5AL including the Q gene.

Q gene

Q gene


Input: Investigations using hippocampal slices maintained in vitro have demonstrated that bursts of oscillatory field potentials in the gamma frequency range (30-80 Hz) are followed by a slower oscillation in the beta 1 range (12-20 Hz).


Input: Karger AG, Basel


Input: During surgery bone cysts were excised and filled by bone grafts.


Input: Urinary LTE4 increased after both challenges the rise being higher following oral as compared to inhalation provocation (p = 0. 0001).


Input: Basal FVR was reduced by approximately 18% by ERT and HRT, but FVR responses to noradrenaline, angiotensin II, acetylcholine and nitroprusside were unaffected.

angiotensin II


Input: Three FGF-AS cDNAs were isolated; the full-length FGF-AS mRNA and two alternative splice variants lacking exon 2 or exons 2 and 3 of the FGF-AS sequence.

FGF-AS cDNAs

full-length FGF-AS mRNA

FGF-AS sequence


Input: Characterization of polymorphic TNRs in novel and even known genes expressed in human spinal cord is likely to help in the identification of new candidates for genes involved in neurodegenerative disorders.


Input: Finally, in situ RNA hybridization studies revealed a very specific pattern of EphA8 gene expression restricted to the rostral region of midbrain tectum during embryonic development.

EphA8 gene


Input: Transfection of cDNAs for three mutant enzymes into FPGS-null Chinese hamster ovary cells restored a reduced level of clonal growth, whereas a T339I mutant supported growth at a level comparable to that of the wild-type enzyme.

FPGS


Input: SETTING: University of Paris VII hospital. Patient (s): Nine women had embolization for symptomatic myoma, with 12 pregnancies observed.


Input: Improving fissure sealant quality: mechanical preparation and filling level.


Input: The Menopause-Rating-Scale (MRS I) was used in clinical practice since 1992.


Input: The MRS II meets a high methodological standard as an instrument standardized in the population.


Input: The protein encoded by the fruA transcript is well conserved with the D. melanogaster type A protein, particularly the BTB protein-protein-binding domain, which is encoded by exons I and II and is 100% conserved.

fruA transcript

D. melanogaster type A protein

BTB protein


Input: In addition, the mouse ortholog (Mharp/Smarcal1) was cloned, and the Caenorhabditis elegans ortholog (CEHARP) was identified in the GenBank database.

Mharp

CEHARP


Input: Sparfloxacin and clinafloxacin were evaluated against Enterococcus faecium SF2149 and Enterococcus faecalis WH245, respectively.


Input: ECP and tryptase levels in serum were measured before and after the last oral challenge.

ECP

tryptase


Input: Tolterodine users were 7. 5 times more likely to have received another spasmolytic drug (RR 7. 5, 95% CI 4. 8 to 11. 9).


Input: For an unsupervised program, the costs were estimated at $311 for the first year and $73 for all additional years.


Input: The presence of such a putative RNA-binding domain suggests a mechanism for the observed autoregulation of bacteriophage T4 DNA polymerase synthesis by binding to its own mRNA.

T4 DNA polymerase


Input: Deletion and mutational analyses revealed two positive cis-regulatory elements in this region that are essential for CSX1 expression in cardiomyocytes.


Input: Functional studies which introduced a mutation in the AP2 core binding region as well as cotransfection experiments using an AP2 expression vector revealed that AP2 exerts a repressive role on the HGF gene promoter activity.

AP2 core binding region

HGF gene promoter


Input: In reconstitution experiments, we first showed that expression in the RAW 264. 7 cell line of C-terminal Src kinase (Csk) inhibited and that of a membrane-anchored, gain-of-function Csk abolished the Fc gamma R-mediated signaling that leads to phagocytosis in a kinase-dependent manner.

C-terminal Src kinase

Csk

Csk

Fc gamma R


Input: In contrast, c-Src-derived construct (a-Src), that was excluded from detergent-resistant membranes, could not restore the series of phagocytosis signaling.

c-Src-derived construct

a-Src


Input: The pJR vectors differ among them in: (a) the selectable marker (Saccharomyces cerevisiae LEU 2 gene, which complements S. pombe leu1-gene and S. pombe ura4 + and his3 + genes); (b) the thiamine-repressible nmt1 promoter (3X, 41X and 81X with extremely high, moderate or low transcription efficiency, respectively); and (c) the multiple cloning site (two multiple cloning sites, with 12 restriction sites each).

LEU 2 gene

S. pombe leu1-gene

ura4 +

his3 + genes

nmt1 promoter


Input: (GUT) Sera of 30 montoux negative healthy adults (age/sex matched) were taken as control by detecting IgG anti bodies to A60 antigen.

IgG anti bodies

A60 antigen


Input: Franz Schubert--his life, music and diseases


Input: These results demonstrate that N-glycans flanking the receptor-binding site of the HA molecule are potent regulators of influenza virus growth, with the glycan at Asn149 being dominant and that at Asn123 being less effective.

HA molecule


Input: RESULTS: The introduction of the PAIP resulted in a significant (p < 0. 001) reduction in contaminating WBCs (median, 30, 000) from the numbers seen with FIP (median, 2, 300, 000) while maintaining the separation efficacy (47%) and separation time.


Input: All were tested for serum ferritin (SF), hemoglobin (Hb) level and asked for detailed histories of donations and iron supplementation.

ferritin

SF

hemoglobin

Hb


Input: Vascular endothelial growth factor (VEGF), a potent agonist secreted by virtually all cells, controls migration and division of vascular endothelial cells.

Vascular endothelial growth factor

VEGF


Input: The antioxidant agent pyrrolidine dithiocarbamate (PDTC) has been shown to protect endothelial cells (EC) from pro-inflammatory-induced and pro-oxidant-induced NF-kappaB activation.

NF-kappaB


Input: We further studied the effects of SIE-1 hypermethylation on p21WAF1 induction by STAT activation.

STAT


Input: In the pRb (-) SAOS-2 cell line transiently transfected with a reporter plasmid containing six tal-1 binding site, pRb enhances the transcriptional activity of tal-1-E12-Lmo2 and tal-1-E12-Lmo2-Ldb1 complexes but not that of a tal-1-E12 heterodimer.

pRb (-)

tal-1 binding site

pRb


Input: This effect was not seen in conjunction with oxycodone, a morphine-like mu-receptor agonist.

morphine-like mu-receptor


Input: Neurofibromatosis of the breast in a patient with Morbus von Recklinghausen


Input: In the premating period male rate of aggression was not significantly correlated with testosterone level.


Input: These results support the hypothesis that in the presence of tryptophan the ribosome translating tnaC blocks Rho' s access to the boxA and rut sites, thereby preventing transcription termination.

tnaC

Rho

boxA

rut sites


Input: In situ hybridization with the antisense RNA probes further supported the expression changes of these six clones and localized the changes in multiple germ cell stages as well as other cell types (Sertoli, interstitial and peritubular cells).


Input: The administration of the GnRH agonist reduced the bone mineral density in the whole femur to 91. 0% of that in the control group.

GnRH


Input: This study shows that C/EBPbeta is the predominant C/EBP isoform found in activated stellate cells and that increased C/EBPbeta protein and C/EBPbeta binding to a proximal C/EBP binding site in the promoter mediates the activating effect of acetaldehyde.

C/EBPbeta

C/EBP isoform

C/EBPbeta protein

C/EBPbeta

C/EBP binding site


Input: As with VP16, the transactivation function of Luman is also regulated by HCF.

Luman

HCF


Input: After two successive rounds of selection by focus formation assay, a transforming ribozyme (Rz007) was identified.


Input: G., and Hyde, C.


Input: The ATR-X syndrome results from mutations of the XH2 gene, located on the X chromosome (Xq13. 3) and coding for a transacting factor which regulates gene expression.

XH2 gene


Input: AIMS: To evaluate the role of environmental intra-uterine factors in determining the birthweights of twins with increased susceptibility to diabetes and discordant for abnormal responses to the oral glucose tolerance test (OGTT) and verify the possible association of within-pair birthweight differences and metabolic abnormalities in adult life.


Input: In NASCIS III, a randomization imbalance occurred that allocated a disproportionate number of patients with no motor deficit (and therefore no chance for recovery) to the lower dose control group.


Input: Penicillin acylase (PA) from Escherichia coli ATCC11105 is a periplasmic heterodimer consisting of a 24 kDa small subunit and a 65 kDa large subunit.

Penicillin acylase

PA


Input: A murine expressed sequence tag (EST) showing homology with erythropoietin receptor (EPOR) was identified in the EST database.

erythropoietin receptor

EPOR


Input: When the LCx was partially occluded, mild PM-induced tachycardia resulted in decreased AoP (P = 0. 045) as well as in decreased SV (P = 0. 048); the LVEDP remained high (P = 0. 002).


Input: Activation of nuclear factor (NF)-kappaB and subsequent proinflammatory gene expression in human airway epithelial cells can be evoked by oxidative stress.

nuclear factor (NF)-kappaB


Input: GAP JUNCTIONS IN THE BRAIN: PREFACE.


Input: We have isolated and functionally characterized the mouse gene for the C2 subunit of the 20S proteasome.

20S proteasome


Input: Furthermore, as in the human gene, the 3' end of the Cacna1f gene maps within 5 kb of the 5' end of the mouse synaptophysin gene in a region orthologous to Xp11. 23.

Cacna1f gene

mouse synaptophysin gene


Input: With the human Rhotekin cDNA as a probe, Northern hybridization revealed that a 4. 0-kb transcript was expressed at a high level in prostate and at a middle level in 13 of 16 tissues examined, but it cannot be detected in liver and lung tissues.

human Rhotekin cDNA


Input: Similarly, co-expression of a dominant-negative mutant of p38alpha, but not of ERK1, ERK2, JNK1, or JNK2, reduces basal and cadmium-induced pE1-luc activity.


Input: BACKGROUND: Gamma knife radiosurgery (GKR) is a safe and effective alternative to surgery for intracranial lesions.


Input: It is mainly transcribed in neural structures and in developing organs characterized by epithelial-mesenchymal interactions.


Input: CONCLUSION: The alpha2-adrenergic antagonist idazoxan increases glucose-induced sympathetic activity but not energy expenditure in obese subjects.


Input: Next, we show that two EMS-induced mutations, previously shown to interact genetically with zipper (Ebr), disrupt the RhoA locus.

Ebr

RhoA locus


Input: Therefore, the results indicate that repeated exposure to amphetamine or apomorphine overcomes the context-dependent component of sensitization of amphetamine-or apomorphine-induced stereotyped behavior.


Input: Testing for serum IgM binding to GM1 ganglioside in clinical practice.

serum IgM


Input: Objective responses also occurred in studies that explored sequential use of exemestane after failure of aminoglutethimide (26% with exemestane 200 mg/day) or other nonsteroidal aromatase inhibitors (6. 6% with exemestane 25 mg/day).

aromatase


Input: The science of tissue engineering.


Input: Endonuclease III (Nth) of Escherichia coli is a DNA glycosylase essential for the removal of oxidised pyrimidine base residues from DNA.

Endonuclease III

Nth

DNA glycosylase


Input: The duration of reactive hyperemia decreased with aging, but the difference between males and females was not significant at any age.


Input: Acquired bile duct blockage: entry of hepatobiliary agent into an intrahepatic abscess.


Input: Furthermore, this study looks at the impact of synthesis conditions on block length and crystallinity, and the impact of the blocking on both, crystallinity and solubility of the polymers.


Input: However, little was understood about the normal function of CREB-2 in mammalian development or organ physiology.


Input: Both the MVBF and the maximum EMG activity in the right masseter and the left anterior temporalis muscles were significantly decreased during muscle pain when the subjects bit on the painful side.


Input: The total alkaloids contained in the peel of Atzimba, Lopez, Marciana, Montsama, Murca, and Puebla was lower than the limits recommended for food safety.


Input: The detection success rate was determined for different markers using this MEK.

MEK


Input: Herein, we show that Smad3 physically interacts with the HMG box domain of LEF1 and that TGFbeta and Wnt pathways synergize to activate transcription of the Xenopus homeobox gene twin (Xtwn).

HMG

TGFbeta

Wnt

twin

Xtwn


Input: The transmembrane topology of Na (+)/H (+) exchanger NHE3 has been studied using in vitro transcription/translation of two types of fusion vectors designed to test membrane insertion properties of cDNA sequences encoding putative NHE3 membrane spanning domains (msds).


Input: Members of the titin/myosin light chain kinase family play an essential role in the organization of the actin/myosin cytoskeleton, especially in sarcomere assembly and function.

titin

myosin light chain kinase

actin

myosin


Input: Furthermore, a pTyr317 Shc phosphopeptide selectively recognized Grb2, Sos1, SHIP, and the p85 subunit of phosphatidylinositol 3' kinase from mast cells, as characterized by mass spectrometry.

pTyr317 Shc phosphopeptide

SHIP

p85 subunit

phosphatidylinositol 3' kinase


Input: Although increased expression of the HMG-I/Y proteins is associated with cellular proliferation, neoplastic transformation, and several human cancers, the role of these proteins in the pathogenesis of malignancy remains unclear.

HMG-I/Y proteins


Input: The naltrexone/lofexidine combination was associated with a more rapid resolution of the opiate withdrawal syndrome than a 7-day lofexidine-only treatment schedule, without substantial increases in withdrawal symptoms or hypotensive side-effects.


Input: The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control.


Input: PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1).

PNRC

steroidogenic factor 1

estrogen related receptor alpha-1


Input: Studies using a reporter plasmid with a functionally disrupted sterol-responsive element (SRE)-1 revealed a reduced stimulatory response to IL-6.


Input: However, there is still a subset of tumors that displayed no changes in these genes.


Input: Bailey Instruments and Owen Mumford filaments were the most accurate with 100% buckling within +/-1. 0 g of 10 g.


Input: PARTICIPANTS: Convenience sample of ambulatory outpatients with hereditary motor and sensory neuropathy, type I (n = 9), myotonic muscular dystrophy (n = 10), and able-bodied controls (n = 11).


Input: The effect of water deprivation for 19 h on renal Na excretion of conscious adrenalectomized (ADX) sheep maintained on a constant intravenous infusion of aldosterone and cortisol (ADX-constant steroid sheep) was investigated.


Input: Neither is it a major cause of rehydration-induced renal Na retention.


Input: CONCLUSION: Rheumatic fever in the Nazareth area is still manifest.


Input: Antithrombin III deficiency: when substitute, when heparin? Thrombosis ABC, 3: The role of antithrombin III

Antithrombin III


Input: Specific class I and II histone deacetylases (HDACs) interact in vivo with BCoR, suggesting that BCoR may functionally link these two classes of HDACs.

class I and II histone deacetylases

HDACs

BCoR

BCoR

HDACs


Input: This is the first example of a eukaryotic transcription factor complex containing both a MADS-box and a forkhead protein, and it has important implications for the regulation of mammalian gene expression.

MADS-box

forkhead protein


Input: After screening the Berkeley Drosophila Genome Project database with sequences from a recently characterized Leu-rich repeats-containing G protein-coupled receptor (LGR) from Drosophila (DLGR-1), we identified a second gene for a different LGR (DLGR-2) and cloned its cDNA.

Leu-rich repeats-containing G protein-coupled receptor

LGR

LGR


Input: Degenerate primers homologous to highly conserved regions of known CYP3A sequences were used for initial RT-PCRs.

CYP3A sequences


Input: When cells were microinjected with TFOs designed to bind to a 30-bp polypurine site situated between the two TK genes, recombination was observed at frequencies in the range of 1%, 2, 500-fold above the background.

TK genes


Input: Methyllevamisole was used as the internal standard.


Input: Only transcripts specific for TSGF-2 are detected in ovary and testes tissues of adults as well as in puparia, while neither gene is expressed during the larval developmental stages.


Input: In a gel retardation assay using HepG2 nuclear extracts, the 5' flanking sequence from-74 to-46 showed a shifted band.


Input: Coimmunoprecipitation experiments performed in transfected cells showed that BCMA associates with TNFR-associated factor (TRAF) 1, TRAF2, and TRAF3 adaptor proteins.

BCMA

TNFR-associated factor (TRAF) 1

TRAF3 adaptor proteins


Input: Since the RINX gene is likely an ortholog of the goldfish Vsx1 gene, it has been named VSX1 by the Human Gene Nomenclature Committee.

RINX gene

goldfish Vsx1 gene


Input: The chromosomal localization on distal chromosome 7 places it in a cluster of imprinted genes, flanked by the previously described Tapa1 and Kcnq1 genes.

Kcnq1 genes


Input: The present study was designed to evaluate the sensitivity and specificity of AMP CT (Gen-Probe Incorporated, San Diego, CA, USA) on urogenital specimens taken from symptomatic patients and on first void urine (FVU) specimens from asymptomatic patients.


Input: The linear plasmid pCLU1 from the yeast Kluyveromyces lactis normally replicates in the cytoplasm, with the aid of the helper linear plasmid pGKL2, using terminal protein (TP) as a primer.

terminal protein

TP


Input: The repetitive ETn (early transposon) family of sequences represents an active " mobile mutagen " in the mouse genome.

ETn

early transposon


Input: The two main experimental variables were the attended hemifield (left or right) and the proportion of trials requiring a shift within that hemifield (20% or 80%).


Input: The measurement of NO in biological systems using chemiluminescence.


Input: Biochemical examinations of calcium-phosphorus metabolism included ions and PTH concentrations in blood serum, and the activity of bone isoenzyme of AP.

PTH

AP


Input: Atorvastatin was the most cost-effective HMG-CoA reductase inhibitor.

HMG-CoA reductase


Input: Pharmacoeconomic assessment of HMG-CoA reductase inhibitor therapy: an analysis based on the CURVES study.

HMG-CoA reductase


Input: Interestingly, although E domains of these two receptors are much less conserved, replacement of this domain in rtER by its human counterpart resulted in higher estradiol sensitivity but no increase in the magnitude of transactivation.

rtER


Input: G-DNA is a four-stranded DNA structure with diverse putative biological roles.


Input: The effectiveness of NRT appears to be largely independent of the intensity of additional support provided to the smoker.


Input: 8% (95% CI, 21. 3-44. 3%).


Input: In contrast, the action of GLP-1 at the CRE was not blocked by cotransfection with M1-CREB, an isoform that lacks a consensus serine residue serving as substrate for PKA-mediated phosphorylation.

PKA


Input: Because all PDGFbetaR fusions described thus far result in splicing to a common exon of this gene, we performed 5'-rapid amplification of cDNA ends PCR on patient RNA.

PDGFbetaR fusions


Input: CONCLUSIONS: In essential hypertension an acute protein load induces a decrease in GFR that may normalize under antihypertensive treatment.


Input: This finding suggested that the PI3K-Akt activation pathway plays some role in the antiapoptotic effect of EPO.

Akt

EPO


Input: Nine DNA fragments that were specifically recognized and bound by histidine-tagged AdpA were isolated by cycles of a gel mobility shift-PCR method.

AdpA


Input: To determine whether the NTP-binding motif is important for Rad24 function, we mutated the conserved lysine (115) residue in this motif.


Input: The carboxyl-terminal proline-rich domain of SOS1 is involved in the interaction with the PLC-gamma1 SH3 domain.

PLC-gamma1 SH3 domain


Input: From transient expression studies, we could demonstrate that the SH3 domain of PLC-gamma1 is necessary for the association with SOS1 in vivo.

SH3 domain


Input: Wnt-1 overexpression in mammary epithelial cells induced cyclin D1 mRNA and targeted overexpression of Wnt-1 in the mammary gland of transgenic mice increased both ILK activity and cyclin D1 levels.

cyclin D1 mRNA

ILK

cyclin D1


Input: Intravenous versus oral administration of amitriptyline in patients with major depression.


Input: Deletion of the RVH domain resulted in loss of Ca (2 +)-dependent activation.

RVH domain


Input: Logistic regression analysis revealed that physicians were 3. 6 times more likely to detect thin lesions (</= 0. 75 mm) compared with nonphysician detectors (95% confidence interval [95% CI], 2. 1, 6. 5; P = 0. 0001).


Input: Erythema exsudativum multiforme induced by granulocyte colony-stimulating factor in an allogeneic peripheral blood stem cell donor.

granulocyte colony-stimulating factor


Input: VaI and VaII co-immunoprecipitated with ErbB2, but not with ErbB1, ErbB3, or ErbB4.


Input: While interactions of WT and variant TGF-alpha with the ErbBs all result in ErbB2 activation, they produce different biological consequences, suggesting that the various TGF-alpha precursors differentially modulate ErbB signaling.

TGF-alpha

ErbBs

TGF-alpha precursors

ErbB


Input: In contrast to full-length E2F-3, which is expressed only at the G1/S boundary, E2F-3B is detected throughout the cell cycle with peak levels in GO where it is associated with Rb.

full-length E2F-3

Rb


Input: Developmental toxicity of the class III antiarrhythmic agent almokalant in mice.


Input: In addition to its effect in augmenting the neutrophil response to eccentric exercise, vitamin E causes a greater increase in circulating creatine kinase activity, perhaps indicating increased skeletal muscle repair.

creatine kinase


Input: CONCLUSION: The authors emphasize that the initial management of primary STS should be adequate and suggest that safty margin of > or = 2 cm should be adhered to.


Input: Measurements were compared with two computerised treatment planning systems--Theraplan VO5B and ADAC Pinnacle3 V4. 0b.


Input: Activation was biphasic; peaking at 5-10 min and 24 h after treatment.


Input: Whereas MARTA1 is clearly detectable in crude lysates, cytosolic and ribosomal salt-wash fractions, and in nuclear extracts, MARTA2 is preferentially found in the ribosomal salt-wash preparation.


Input: Five of the PDP1 isoforms differ by the substitution or insertion of amino acids at or near the N-terminal of the protein.

PDP1 isoforms


Input: The optimum technique for the pathological examination of sentinel lymph nodes (SLNs) is still under debate.


Input: Partial correction of anemia with recombinant human erythropoietin likely reduces left ventricular mass and volume.

recombinant human erythropoietin


Input: This study demonstrated that the PFA-100 analyzer can accurately assess vWF-dependent platelet function and detect other platelet defects under high shear stress in complex patient populations.

vWF


Input: We recently reported the molecular cloning of a PL scramblase of human (HuPLSCR1) and mouse origin, respectively.

PL scramblase


Input: To analyze the regulatory activity of Gtx, we first identified the optimal Gtx-binding sequence using an in vitro DNA-binding assay.

Gtx

Gtx-binding sequence


Input: Using an oligomer duplex 5'-A (GGGTTA) (5)-3'/5'-(TAACCC) (5) T-3' as a template-primer, we show that both the Klenow fragment of Escherichia coli DNA polymerase I and HIV reverse transcriptase could expand telomere DNA sequences as well, giving products greater than the size of the template DNA.

Klenow fragment of Escherichia coli DNA polymerase I

HIV reverse transcriptase


Input: Cdk2 and MAPK precipitates from untreated tumor lysates phosphorylated recombinant wild-type p27 but not the T187A mutant in vitro.

MAPK

recombinant wild-type p27


Input: The loss of avirulence activity because of mutations in the acidic transcriptional activation domain was restored by addition of the activation domain from the herpes simplex viral protein VP16.

herpes simplex viral protein VP16


Input: Mutations in the RP2 locus at Xp11. 3 were found in a further 10-20% of XLRP patients, as predicted from linkage studies.

RP2 locus at Xp11. 3


Input: Subsequently, HD inhibited healing because it significantly delayed epithelialization and caused protracted inflammation.


Input: The effectiveness of the haemodialysate Solcoseryl for second-intention wound healing in horses and ponies.


Input: Although there is little evidence that diet composition plays a clinically important role in the absorption or expenditure of energy, it does appear to play a role in food intake.


Input: These findings were reinforced by an analysis that was restricted to living donor transplants without acute rejection.


Input: The genome of the human herpesvirus 8 (HHV-8) contains a cluster of open reading frames (ORFs) encoding proteins with homology to the cellular transcription factors of the interferon regulatory factor (IRF) family.

interferon regulatory factor

IRF


Input: Despite these limitations the CHIME monitor provides an opportunity to record physiological data previously unavailable in the home.


Input: DATA SYNTHESIS: Intracoronary ultrasound has been shown to improve upon demonstrated weaknesses of coronary angiography.


Input: TB bone area (p < 0. 001), height (p < 0. 01), years in present colony (p = 0. 03), and menses (p < 0. 01) predicted TB BMC.


Input: CREST syndrome; a changing clinical significance


Input: Troglitazone also induced an endogenous PPARgamma target gene in T24 cells, adipocyte-type fatty acid binding protein (A-FABP), the expression of which correlates with bladder cancer differentiation.

endogenous PPARgamma target gene

adipocyte-type fatty acid binding protein

A-FABP


Input: The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.

RS447 human megasatellite tandem repetitive sequence


Input: Previous experience and contextual cues are essential elements in the generation of a subjective prediction.


Input: To characterize this effect, we looked for targets of NS1 influenza virus protein among cellular translation factors.

NS1 influenza virus protein


Input: Collectively, these and previously published data suggest a model where NS1 recruits eIF4GI specifically to the 5' untranslated region (5' UTR) of the viral mRNA, allowing for the preferential translation of the influenza virus messengers.


Input: Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus.

Eukaryotic translation initiation factor 4GI

NS1 protein


Input: (iii) In these cells, PKCbeta plays a unique Ras-independent role in mediating insulin but not EGF or other growth factor mitogenic signals.

PKCbeta

Ras

insulin

EGF


Input: However, it is not known whether the recently identified isoforms Vav2 and Vav3, which are broadly expressed, can couple with similar classes of receptors, nor is it known whether all Vav isoforms possess identical functional activities.

Vav isoforms


Input: Transcriptional regulation of fbp1 promoter constructs containing only UAS1 or UAS2 confirms that the PKA and MAPK regulation is targeted to both sites.

fbp1 promoter constructs

PKA

MAPK


Input: X-ray crystallographic data show that the PLZF BTB/POZ domain forms an obligate homodimer via an extensive interface.

PLZF BTB


Input: The ability of SMRT to associate with these transcription factors and thereby to mediate repression is strongly inhibited by activation of tyrosine kinase signaling pathways, such as that represented by the epidermal growth factor receptor.

SMRT

tyrosine kinase

epidermal growth factor receptor


Input: In addition, the ketamine-treated rats had more neurons and glial cells surrounding the ventricles.


Input: The differences were as follows: for overall response rate p = 0. 004; power (for p = 0. 05) 85%; for survival p = 0. 09; for grade IV granulocytopenia p = 0. 3; and for febrile neutropenia p = 0. 61.


Input: Patients were randomly assigned to treatment with the ACE inhibitor perindopril (and the diuretic indapamide for those with no definite indication for or contraindication to treatment with a diuretic) or matching placebo (s).

ACE


Input: The results indicate that the open-section effect decreases the torsional stiffness and stress concentration effects decrease the torsional strength of a long bone with a longitudinal defect.


Input: These regions may be differentially involved in tissue-specificity, and/or circadian regulation, of the human hPer1 gene transcription.

human hPer1 gene


Input: Additionally, putative CF1/USP and Broad Complex Z2 transcription factor elements were found in the upstream regions of MIH and MO-IH genes respectively.

USP

Broad Complex Z2

MIH

MO-IH


Input: Sequence analysis reveals that the newly discovered oasA2 gene represents a pseudogene that is still transcribed, but is not functionally translated.

oasA2 gene


Input: Genomic and functional characterization of the oas gene family encoding O-acetylserine (thiol) lyases, enzymes catalyzing the final step in cysteine biosynthesis in Arabidopsis thaliana.

oas gene family

O-acetylserine (thiol) lyases


Input: Two distinct recessive susceptibility loci for vasculitis were mapped on chromosome (Chr) 4 at D4Mit89 and D4Mit147 in both progenies.


Input: Further characterization of these putative Hoxa-1 target genes will aid in delineating the functions of the Hoxa-1 protein in the differentiation processes which occur during embryogenesis.

Hoxa-1 target genes

Hoxa-1 protein


Input: The ability of U6-U57 mutants to influence the fidelity of both branch site and 3' splice site recognition suggests that this nucleotide may participate in the formation of the active site (s) of the spliceosome.


Input: We have determined the structure of the WNT-2B gene.

WNT-2B gene


Input: The role of daunorubicin in induction therapy for adult acute myeloid leukemia


Input: TNF-alpha induced a dose-and time-dependent increase in cyclooxygenase-2 (COX-2) expression and PGE2 formation in human NCI-H292 epithelial cells.

TNF-alpha


Input: The therapy time to deliver the NCS therapeutic dose of 10000 RBE-cGy, is 27 times longer when 157Gd is used instead of 10B.


Input: Mis3 is needed for the formation of 18S ribosome RNA, and may hence direct the level of proteins required for the coupling.

18S ribosome RNA


Input: Losartan Intervention For Endpoint.


Input: CONCLUSION: Vitrectomy for vitreous hemorrhage in Terson syndrome is a safe and effective procedure, offering a rapid and prolonged improvement in vision.


Input: RNA in situ hybridization on brain sections of normal human embryos revealed a strong labeling in restricted areas of the cerebral cortex.


Input: To facilitate manipulation of large genomic sequences, we developed a method of converting Escherichia coli P1 artificial chromosomes (PACs) into yeast artificial chromosomes (YACs).


Input: After gamma-irradiation, the majority of F9 cells undergo apoptosis implying that wt-p53 likely triggers pro-apoptotic gene expression in DNA damaged cells.


Input: Mobilization with cyclophosphamide and granulocyte-colony stimulating factor was effective in terms of CD34 + cell shift to peripheral blood and the good quality autograft reliably led to haematopoetic recovery after megachemotherapy.

granulocyte-colony stimulating factor

CD34 +


Input: This suggests that cardiovascular magnetic resonance is the preferred technique for volume and ejection fraction estimation in heart failure patients, because of its 3D approach for non-symmetric ventricles and superior image quality.


Input: A degenerate DNA transposon, Pat, was identified in the genomes of various wild-type strains of the filamentous fungus Podospora anserina.

Pat


Input: However, the presence of Tax I increased the extent and altered the profile of proteins binding TRE-2 in vivo.

Tax I


Input: We have also identified a functional domain in the ORF 50 protein, an immediate-early gene product that is mainly encoded by ORF 50.

immediate-early gene product


Input: A 2. 3-kb full-length cDNA clone of an Atlantic halibut Mx gene was isolated from a liver cDNA library.

Atlantic halibut Mx gene


Input: PLUS-3 is a new Swedish protocol of natural speech in 3-year-old children.


Input: Once HIT II is suspected, heparin (and low-molecular-weight heparins) should be stopped immediately.


Input: The reduced efficiency in the glycosylase activity is also reflected in a reduced ability of S120K MutY to prevent DNA mutations in vivo.

glycosylase

S120K MutY


Input: METHODS AND RESULTS: We prospectively compared the automated measurements of left ventricular ejection fraction (LVEF) and volumes from rest-injected gated Technetium 99m (Tc99m) perfusion SPECT with equilibrium radionuclide angiocardiography (ERNA) in 62 patients and the assessment of regional function with echocardiography in 22 patients.


Input: This intracellular signaling, known as the unfolded protein response (UPR), is mediated by the cis-acting ER stress response element (ERSE) in mammals.


Input: A Y. lipolytica Kar2p mutant was isolated that restored interaction with an Sls1p mutant, suggesting that the interaction with Sls1p could be nucleotide and/or conformation dependent.

Y. lipolytica Kar2p mutant

Sls1p mutant


Input: We have carried out a comprehensive and systematic mutagenesis of the Cse4p N terminus to analyze its function.

Cse4p N terminus


Input: The spacing of the essential N-terminal domain (END) relative to the HFD can be changed significantly without an apparent effect on Cse4p function.

HFD


Input: The bases of this comparison are reviewed and discussed.


Input: In invertebrates, Fhit is encoded as a fusion protein with Nit, a member of the nitrilase superfamily.

Fhit

Nit

nitrilase superfamily


Input: The manifestations often include a moderate thrombocytopenia and, less commonly, hemolysis.


Input: A beta2 RARE reporter construct in which the methylation-susceptible cytosines in the sense strand were replaced by thymine displayed marked loss of activity in a replicated chromatin-dependent manner.

beta2 RARE reporter construct


Input: Non-poliomyelitis AFP rate had increased from 0. 9 in 1997 to 2. 8 in 1998.


Input: Consciousness is connected with attention, working memory and perception.


Input: Multiparity had a protective effect with 0. 66 less risk (95% CI 0. 44-0. 99).


Input: Picture the smell.


Input: Only two of 27 participants (7. 4%) with definite POAG had been previously diagnosed and treated, and 66. 7% of the previously undiagnosed had IOP less than 22 mmHg.


Input: Taken together, they uphold the emerging concern that women with ER (+) cancers may not benefit significantly from endocrine treatment if the tumors also overexpress HER-2.

ER (+)


Input: Promoter activity was dose-dependently inhibited by cotransfection with either ras or mos oncogenes, but oncogene inhibition was reversed and the overall activity increased when cells were treated with the MAP kinase kinase (MKK) inhibitor PD98059.

ras

mos oncogenes

MAP kinase kinase

MKK


Input: Our results indicate that the expression of Cktsf1b1, a gene associated with early development and cell transformation, is sensitive to MKK levels and may be regulated via multiple transcription factor complexes.

MKK


Input: INTERVENTIONS: Subcutaneous tissue PO2 and PCO2 tensions were measured directly in patients with necrotising fasciitis and in healthy volunteers during normobaric and hyperbaric conditions.


Input: Because GH-induced Akt activation was completely inhibited in both cells by the same concentration of LY294002, these findings indicate that the wortmannin sensitivity of both the IRS-1-independent and-dependent GH-induced MAP kinase activation may reflect the activity of another wortmannin-sensitive target (s) in addition to PI3K in mediation of GH-induced MAP kinase activation in these cells.

GH

Akt

GH

MAP kinase

GH

MAP kinase


Input: Insulin receptor substrate-1-mediated enhancement of growth hormone-induced mitogen-activated protein kinase activation.

Insulin receptor substrate-1

growth hormone

mitogen-activated protein kinase


Input: Functional magnetic resonance imaging (fMRI) has been increasingly used in studying human brain function given its non-invasive feature and good spatial resolution.


Input: After declamping of the aorta, there were also severe edema, local fibre necrosis, and adhesion of leucocytes, whereas muscle fibre areas became 3, 935. 18 micro 531 microm (2) for type I and 5, 804 +/-1, 075 microm (2) for type II.


Input: It was found that increase in the RH level boosts the current values by 2-3 orders of magnitude; contrariwise, the voltage values rise by about three times with drop in the RH.


Input: Genomic libraries were stored as frozen cultures in a 96-well format, each well containing approximately 300-600 colonies (12 plates for small library, four for medium-size library and four for large library).


Input: In several cell lines, mTOR or its downstream targets can be regulated by phosphatidylinositol (PI) 3-kinase; protein kinases A, B, and C; heterotrimeric G-proteins; a PD98059-sensitive kinase or calcium; as well as by amino acids.

mTOR

phosphatidylinositol (PI) 3-kinase

protein kinases A, B, and C

heterotrimeric G-proteins


Input: The importance of this new epidemiological profile of schistosomiasis in the State of Pernambuco relies on the fact that it can be related with the drastic human interference on the environment.


Input: RESULTS: No significant deformation in vertebral artery flow was noted in the flexion-distraction Stage I injuries within the physiologic range of cervical flexion.


Input: We screened a K562 cDNA library and identified novel transcripts, MZF1B and MZF1C.


Input: The human cDNA clone NFBD1 (previously designated KIAA0170) encodes a novel protein (2089 amino acids in length; calculated molecular mass 226, 440 D) with possible BRCT domains at its carboxy terminus (amino acid residues 1894-2089).

BRCT domains


Input: RESULTS: Neither basal FSH level nor stimulated FSH level alone were statistically significant predictors of IVF success; however, no patient with a day 3 FSH level > 11. 1 mIU/ml or a stimulated day 10 FSH level > 13. 5 mIU/ml conceived and carried a pregnancy.

FSH

FSH

FSH

FSH


Input: Parathyroid hormone regulation of bone sialoprotein (BSP) gene transcription is mediated through a pituitary-specific transcription factor-1 (Pit-1) motif in the rat BSP gene promoter.

Parathyroid hormone

bone sialoprotein

BSP

pituitary-specific transcription factor-1

rat BSP gene promoter


Input: Recent target BP goals promulgated by the Sixth Report from the Joint National Committee (JNC VI) are based on the premise that the intensity of treatment directly corresponds to the magnitude of pretreatment risk.


Input: Linking continuous community-based morbidity recording of influenza-like illness (ILI) with virological sampling has consistently proved its value as one of the earliest indicators of circulating influenza activity.


Input: These include NPF repeats, a leucine heptad repeat enriched in charged residues, and a proline-rich SH3-like and/or WW domain-binding site in the N-terminal domain, which is followed by a membrane core containing four putative transmembrane spans and three amphiphilic segments that are the most highly conserved structural elements.


Input: We show here that this difference is due to the presence of a Mot3 binding site in OpA.

Mot3 binding site

OpA


Input: The article deals with the diagnosing and correction of reversible ischemia of the intestine.


Input: Functional recognition of 5' splice site by U4/U6. U5 tri-snRNP defines a novel ATP-dependent step in early spliceosome assembly.


Input: As control, the cells were transfected with DNA mixtures containing vector mU6-C1 or mU6-C2.


Input: In this regard, we have recently observed that a constitutively active G protein-coupled receptor (GPCR) encoded by the Kaposi' s sarcoma-associated herpes virus (KSHV)/human herpes virus 8 is oncogenic and stimulates angiogenesis by increasing the secretion of vascular endothelial growth factor (VEGF), which is a key angiogenic stimulator and a critical mitogen for the development of Kaposi' s sarcoma.

G protein-coupled receptor

GPCR

vascular endothelial growth factor

VEGF


Input: No specific subgroup of clients benefited more from URD, although a prospective study employing random assignment might be more successful in identifying such a group.


Input: In the lattice, 23% of the sites are occupied, 95% of the atoms are in the lowest energy magnetic sublevel, and 37% are in the lowest 3D vibrational state.


Input: Coexisting vertical and horizontal one and a half syndromes.


Input: As in the other three members whose gene expression is altered during tumorigenesis, PI12 expression was found to be down-regulated in tumor brain tissues and in two brain cancer cell lines: U-87 MG and H4.


Input: This slope was further significantly decreased at 5 min ischemia (-26. 5 +/-8. 8 microm/mmHg) but returned toward control values in short-term hibernating myocardium at 90 min ischemia (-17. 2 +/-6. 6 microm/mmHg).


Input: Whereas both MAP and MSNA increase during SHG, the transition from SHG to PHI is characterized by a transient reduction in MAP but sustained elevation in MSNA, facilitating separation of these factors in vivo.


Input: We have recently discovered that CCAAAT/enhancer-binding protein-beta (C/EBP-beta) induces gene transcription through a novel IFN response element called the gamma-IFN-activated transcriptional element

CCAAAT/enhancer-binding protein-beta

C/EBP-beta

IFN response element


Input: Northern blot analysis demonstrated that the STORP gene has a ubiquitous pattern of expression similar to that of the PML gene.

STORP gene

PML gene


Input: In the TLE patients the NAA: Cr ratios were reduced in the seizure focus, while in the FLE patients they were not always reduced in the seizure focus.


Input: The psychologic factors associated wth serious illness, terminal prognoses, and dying complicate the scenario even more as compared with that of nonmalignant pain.


Input: However, if the spatial resolution is not critical and interest is to compare a pathologic area with a contralateral VOI, then the acquisition of two single-voxel spectra may be preferred.


Input: Quantitative evaluation of magneto-optical parameters is necessary in order to apply scanning near-field optical microscope (SNOM) technology to the study of magnetism on the mesoscopic scale.


Input: We found that the amplitude of the cortical evoked potentials (amplitude of the N2/P2 peak) increased from 5. 1 +/-0. 7 microV at 5 mA to 16. 3 +/-1. 1 microV at 20 mA.


Input: LMP-1 is targeted to the plasma membrane, where it binds TRAF, TRADD, and JAK molecules to activate NF-kappaB-, AP-1-, and STAT-dependent pathways as does CD40.

TRAF

TRADD

JAK molecules

NF-kappaB

STAT


Input: Identification of an enhancer and an alternative promoter in the first intron of the alpha-fetoprotein gene.

alpha-fetoprotein gene


Input: Studying intracellular signaling pathways, which may be involved in malignant transformation of Ret-9bp expressing NIH3T3 cells, we could demonstrate Ret-9bp dependent phosphorylation of insulin receptor substrate-2 (IRS-2) with consecutive activation of phosphatidylinositol 3-kinase (PI 3-kinase) and protein kinase B (PKB/AKT).

insulin receptor substrate-2

phosphatidylinositol 3-kinase

PI 3-kinase

protein kinase B

PKB

AKT


Input: METHODS: In the current study the authors reported on PPB cases from a national retrospective search performed in 18 Italian Associations for Pediatric Hematology and Oncology centers.


Input: Phylogenetic analysis showed that the ToLCV isolates from Bangalore constitute a group of viruses separated from those of Northern India.


Input: Mutating the Fcp1p-binding motif KEFGK in the RAP74 (Tfg1p) subunit of TFIIF to EEFGE led to both synthetic phenotypes in certain fcp1 tfg1 double mutants and a reduced ability of Fcp1p to activate transcription when it is artificially tethered to a promoter.

TFIIF

fcp1 tfg1


Input: Deletion of an intergenic DNA-binding site for this complex from a human beta-globin locus construct results in delayed human gamma-to beta-globin switching in transgenic mice, suggesting that the PYR complex acts to facilitate the switch.

human beta-globin locus construct

human gamma-to beta-globin

PYR complex


Input: The product of rat gene 33 was identified as an ErbB-2-interacting protein in a two-hybrid screen employing the ErbB-2 juxtamembrane and kinase domains as bait.

rat gene 33

ErbB-2-interacting protein

ErbB-2 juxtamembrane and kinase domains


Input: Studies suggest that the DGOR without acid reflux may result in symptoms but unless acid reflux is present simultaneously, it does not cause oesophagitis.


Input: OBJECTIVE: To evaluate the relationship between blood flow in the tumor assessed by color Doppler ultrasound, microvessel density, and vascular endothelial growth factor levels in endometrial carcinoma.

vascular endothelial growth factor


Input: These results demonstrate Ras-and Raf-independent ERK MAPK activation maintains cell viability following heat shock.

Ras

Raf

ERK


Input: Three cDNAs encoding basic leucine zipper (bZIP)-type ABRE-binding proteins were isolated by using the yeast one-hybrid system and were designated AREB1, AREB2, and AREB3 (ABA-responsive element binding protein).

basic leucine zipper (bZIP)-type ABRE-binding proteins

ABA-responsive element binding protein


Input: Recombinant AROM-p64 displayed high binding to single-stranded DNA and poly (A) homopolymers suggesting that this protein could play a role in mRNA maturation/metabolism.

AROM


Input: The protein-tyrosine kinase fer associates with signaling complexes containing insulin receptor substrate-1 and phosphatidylinositol 3-kinase.

protein-tyrosine kinase fer

insulin receptor substrate-1

phosphatidylinositol 3-kinase


Input: In the PMR target area but not in the nontreated area an improvement in regional myocardial flow reserve occurs in wall segments with initially severely or moderately reduced stress perfusion.


Input: Analysis of intron/exon boundaries of the genomic BAC clones demonstrate that junctin, junctate, and aspartyl beta-hydroxylase result from alternative splicing of the same gene.

junctin

junctate

aspartyl beta-hydroxylase


Input: The growth factor receptor-bound protein 2 (Grb2) adaptor when complexed with Sos (Son of sevenless), the exchange factor of Ras, conveys the signal induced by tyrosine kinase-activated receptor to Ras by recruiting Sos to the membrane, allowing activation of Ras.

growth factor receptor-bound protein 2

Sos

Son of sevenless

Ras

tyrosine kinase-activated receptor

Ras

Sos

Ras


Input: Mutations in genes encoding PR65/A subunits have been identified in several different human cancers and the PP2A inhibitor, termed fostriecin, is being tested as an anticancer drug.

PR65/A subunits


Input: For this purpose, a segment of dxr was amplified from Synechococcus leopoliensis SAUG 1402-1 DNA via PCR using oligonucleotides for conserved regions.

dxr


Input: Perceptual learning for a pattern discrimination task.


Input: While this Saccharomyces cerevisiae SIN4 gene product is a component of a mediator complex associated with RNA polymerase II, various studies suggest the involvement of Sin4 in the alteration of higher-order chromatin structure.

SIN4 gene product

RNA polymerase II


Input: Src activation induced by FGF1 was blocked by the SH2 domain of Src and PP2, a specific inhibitor of Src.

Src

SH2 domain

Src

Src


Input: The use of the PLCgamma inhibitory peptide, neomycin and the calcium chelator BAPTA-AM on oocytes expressing FGFR1 or the stimulation by PDGF-BB of oocytes expressing PDGFR-FGFR1 mutated on the PLCgamma binding site, prevented GVBD and ERK2 phosphorylation.

PLCgamma inhibitory peptide

PDGF-BB

PDGFR

PLCgamma binding site


Input: Multiple transcription start sites were revealed by primer extension analysis of the mouse gene, and transfection constructs containing the prospective promoter generated transcriptional activity comparable to that of the SV40 promoter.

SV40 promoter


Input: To determine whether interaction of arsenite with the hormone-binding domain results in receptor activation, COS-1 cells were transiently cotransfected with the chimeric receptors GAL-ER, which contains the hormone-binding domain of ERalpha and the DNA-binding domain of the transcription factor GAL4, and a GAL4-responsive CAT reporter gene.

chimeric receptors GAL-ER

ERalpha

CAT reporter gene


Input: The mean day of diagnosis of periventricular echodensities was 3 +/-2 days (range 1-11 days), and of cystic PVL 21 +/-8 days (range 2-47 days).


Input: The LAMMER protein kinase encoded by the Doa locus of Drosophila is required in both somatic and germline cells and is expressed as both nuclear and cytoplasmic isoforms throughout development.

LAMMER

Doa locus


Input: We have mutated to cysteine, one at a time, 21 consecutive residues in the fourth TMS (TM4).


Input: (1995) J.


Input: HYPOTHESIS: The aim of this study was to investigate the oxidative susceptibility of apolipoprotein B-containing lipoproteins and antioxidant status in patients with acute coronary syndromes and chronic stable angina pectoris.

apolipoprotein B-containing lipoproteins


Input: In group B 37 MBq in 150 microL of 99mTc-HSA nanocolloid was additionally injected intradermally 18 h before surgery (3-6 aliquots injected perilesionally).


Input: Post-operative functional outcome is related to pre-operative functional status.


Input: We cloned a DNA fragment encoding the N-terminal part of a protein with significant similarity to members of the LysR family of transcriptional regulators (LTTRs).

LysR family of transcriptional regulators

LTTRs


Input: AGO1 is similar to QDE-2 required for quelling and RDE-1 required for RNAi.


Input: We could demonstrate the involvement of cAMP-dependent protein kinase (PKA) in the phosphorylation of CDC25Mm in fibroblasts overexpressing this RasGEF as well as in mouse brain synaptosomal membranes.

cAMP-dependent protein kinase

PKA

RasGEF


Input: We find that 3T1-3T2 mixing has a pronounced effect on the line shape and radiative decay rate of emission from the 3T2 state and that the extent of mixing depends critically on the magnitude of nontetrahedral distortions.


Input: A total of 576 1-day-old Ross broiler chicks were housed in six treatment groups [six replicates of 16 each; control, CLI (15 g kg (-1) diet), 50 parts per billion (ppb) AF, 50 ppb AF plus CLI, 100 ppb AF, 100 ppb AF plus CLI] for 42 days.

AF

AF

AF

AF


Input: The cost per test is less than those for CC, kEIA and PACE2.


Input: Concurrently, we monitored weather conditions and used time-activity budget data of free-living birds and laboratory data on resting metabolic rate to construct time-activity laboratory (TAL) estimates of daily energy expenditure (DEE) and to partition the verdins' energy budget into thermoregulatory, activity and basal components.


Input: L/H > 0. 61 (chi (2) = 10. 8; P: < 0. 001) and a restrictive filling pattern (chi (2) = 3. 6; P: < 0. 05) were independent predictors of events.


Input: The high selectivity of arrestins for this particular functional form of receptor ensures their timely binding and dissociation.

arrestins


Input: When cotransfected in fibroblasts with a C/EBP alpha expression vector, reporter gene expression increased 3-fold only in the wild-type constructs.

C/EBP alpha


Input: Expression of a dominant negative Smad2 significantly reduces the level of luciferase reporter activity induced by nodal treatment.

dominant negative Smad2

luciferase reporter


Input: Normal alpha1 (I) collagen mRNA showed no significant reduction when AR or IR was expressed from the pHbetaAPr-1-neo vector and a small (10-20%) but significant reduction when either ribozyme was expressed from the pCI. neo vector.

alpha1 (I) collagen mRNA


Input: Nature 398, 828-830) that the amino acid sequences of peptide fragments obtained from a polypeptide found in a complex of proteins that alters chromatin structure (ARC) are identical to portions of the deduced open reading frame of TIG-1 mRNA.

ARC

TIG-1 mRNA


Input: Abnormalities of plasma cholecystokinin were observed only in patients with delayed gastric emptying.

plasma cholecystokinin


Input: 5 (Sunset Yellow FCF) were determined using liquid chromatography/mass spectrometry (LC/MS) with electrospray ionization.


Input: Cam kinase II induces in vivo phosphorylation of Smad2 and Smad4 and, to a lesser extent, Smad3.

Cam kinase II


Input: This interaction inhibits the histone acetyltransferase activity of p300, resulting in drastic reduction of nucleosomal histone acetylation and alteration of chromatin structure.

histone acetyltransferase

histone


Input: Recombinant BRI1-KD autophosphorylated on serine (Ser) and threonine (Thr) residues with p-Ser predominating.

Recombinant BRI1-KD


Input: Flow cytomery was used for cell cycle analysis.


Input: Further research is required to better measure treatment effects, modification of MS natural history, and net societal costs of IFN beta-1b in RRMS.

IFN beta-1b


Input: Cost-effectiveness of interferon beta-1b in slowing multiple sclerosis disability progression.

interferon beta-1b


Input: Both the Cmax and AUC values were almost doubled with doubling the dose.


Input: Hyperactivation of Cdc2 in fission yeast causes cells to undergo a lethal premature mitosis called mitotic catastrophe.


Input: Diary.


Input: Cells differentiate in response to various extracellular stimuli.


Input: Transforming growth factor-beta1 (TGF-beta1) can act as a tumor suppressor or a tumor promoter depending on the characteristics of the malignant cell.

Transforming growth factor-beta1


Input: Mn2 + increased both the junction binding and cleaving activities of the mutant proteins.


Input: While Pt; cycH; 1 and Os; cycH; 1 were expressed in all tissues examined, the transcripts accumulated abundantly in dividing cells.

Pt; cycH; 1

Os; cycH; 1


Input: Moreover, an in vitro pull-down assay showed that Os; CycH; 1 specifically bound to R2 but not to other rice CDKs.

Os; CycH; 1

rice CDKs


Input: In transient analysis using particle bombardment of tobacco leaf sections, a tetramer of the distB ABRE (abscisic acid-responsive element) mediated transactivation by ABI3 and ABI3-dependent response to ABA, whereas a tetramer of the composite RY/G complex, containing RY repeats and a G-box, mediated only ABA-independent transactivation by ABI3.


Input: The major neurological manifestations of brain injury in these babies are spastic motor deficits.


Input: Spores from Rhizopus stolonifer were suspended in distilled water (1 x 10 (6) spores/mL) and used as starter.


Input: The LMW FGF-2 up-regulated the PKC epsilon levels by 1. 6-fold; by contrast the HMW isoform down-regulated the level of this PKC isotype by about 3-fold and increased the amount of PKC delta by 1. 7-fold.

LMW FGF-2

PKC epsilon

HMW isoform

PKC isotype

PKC delta


Input: Helicobacter pylori and stomach diseases: from clinical point of view


Input: For this purpose, the writhing test, capsaicin and formalin induced-pain in mice were used.


Input: 2000 update of recommendations for the use of hematopoietic colony-stimulating factors: evidence-based, clinical practice guidelines.

hematopoietic colony-stimulating factors


Input: Prominent findings were chronic pancreatitis with acinar and ductal plugs, granulomatous and necrotizing peripancreatic steatitis, degenerative myopathy, testicular atrophy, candidiasis and bacterial necrotizing glossitis.


Input: Taken together, our data indicate that multiple survival pathways are triggered via this receptor, whereas NF-kappaB/Rel and PI-3K are crucial for CD40-induced proliferation.

NF-kappaB

Rel


Input: In vitro, Arix and NBPhox form DNA-independent multimers and exhibit cooperative binding to the DB1 regulatory element, which contains two homeodomain recognition sites.

Arix

NBPhox

DB1 regulatory element

homeodomain recognition sites


Input: We conclude from this study that Arix and NBPhox exhibit indistinguishable and independent transcriptional regulatory properties on the DBH promoter.

Arix

NBPhox

DBH promoter


Input: METHODS AND RESULTS: Studies were undertaken in 9 isolated guinea pig hearts, which demonstrated reverse use-dependent prolongation of cardiac repolarization by 100 nmol/L domperidone.


Input: OBJECTIVE: To evaluate the overall performance of a new oscillometric wrist blood pressure monitor (Braun PrecisionSensor, Braun GmbH, Kronberg, Germany) as defined by the ANSI/AAMI SP10-1992 guidelines, and to analyze the data for the optimized selection of the algorithm that derives the blood pressure values from the oscillometric blood pressure curves.


Input: Following the results of toxicological experiments in the target animals " Toxicological Drinking Water Standards for Animals " can be established.


Input: An increase in hypothalamic expression of at least two of the erbB receptors is initiated before the pubertal augmentation of gonadal steroid secretion and is completed on the day of the first preovulatory surge of gonadotropins.

erbB receptors

gonadotropins


Input: Dsh is required for two different pathways, the Wnt pathway and planar polarity pathway in Drosophila.

Dsh

Wnt


Input: Catch-up growth and craniofacial dimensions following administration of the antineoplastic agent vincristine to young rats.


Input: CONCLUSIONS: LSCC malformation, like other inner ear malformations such as large vestibular aqueduct and X-linked mixed deafness with perilymph gusher, can be associated with CHL, SNHL, or normal hearing.


Input: Escalation to 180 mg/m2 was to be carried out if white blood cell nadir count was > 2. 0 x 10 (9)/l and platelet nadir count was > 75 x 10 (9)/l.


Input: Methyl formate was used as the solvent of biodegradable oligoesters for the fabrication of microspheres with encapsulated bovine serum albumin (BSA).

bovine serum albumin

BSA


Input: The small monomeric GTP-binding proteins of the RAB subfamily are key regulatory elements of the machinery that controls membrane traffic in eukaryotic cells.

small monomeric GTP-binding proteins

RAB subfamily


Input: Furthermore, loss of methylation also greatly reduced the association of another yeast B-type subunit, Rts1p.


Input: Thus, methylation of Pph21p is important for formation of PP2A trimeric and dimeric complexes, and consequently, for PP2A function.

PP2A trimeric and dimeric complexes


Input: The purpose of this study was to analyze the temporal characteristics and the spatial mapping of the independent components identified by ICA when the subject performs a finger-tapping task.


Input: The authors present the only two studies that have proved successful in treating animal models of osteoarthritis using gene therapy, and propose an overview of several strategies for the development of gene therapy in osteoarthritis treatment in the future.


Input: Together, these results indicate that IL-1 beta induces VEGF gene expression at both transcriptional and post-transcriptional levels, and IL-1 beta evokes p38 MAPK and JNK signalings, which in turn stimulate the transcription of the VEGF gene through Sp1-binding sites.

IL-1 beta

VEGF gene

IL-1 beta

JNK

VEGF gene

Sp1-binding sites


Input: Binding of NusA to RNA in the presence of alpha or N involves an amino-terminal S1 homology region that is otherwise inactive in full-length NusA.

NusA

amino-terminal S1 homology region

full-length NusA


Input: The subjects were diagnosed on the basis of DSM-IV pathological gambling criteria and completed the Turkish Version of South Oaks Gambling Screen (SOGS).


Input: Lys (193) and Arg (194), located at the COOH-terminal end of HD, are essential for dimerization.

HD


Input: Elevation of intracellular Ca (2 +) levels are also involved because treatment with receptor-associated protein, nifedipine, MK801, removal of Ca (2 +) from the medium and dantrolene all served to inhibit calcium elevation and attenuate the activation of CREB.

CREB


Input: The present study shows that phosphatidylinositol 3-kinase-dependent p38 kinase activation regulates Akt phosphorylation and activity in human neutrophils.

phosphatidylinositol 3-kinase

p38 kinase

Akt


Input: When BFDS was taken as the reference, W/A Z scores showed consistent positive increments, from birth in girls and 1 mo in boys.


Input: Using purified recombinant HMG I, we have identified several high-affinity binding sites which overlap important transcription factor binding sites.

recombinant HMG I


Input: High-mobility-group protein I can modulate binding of transcription factors to the U5 region of the human immunodeficiency virus type 1 proviral promoter.

High-mobility-group protein I

U5 region

human immunodeficiency virus type 1 proviral promoter


Input: Leptinaemia does not correlate with the actual or mean blood pressure reading nor with stage of hypertension according to the WHO classification.


Input: Thus, diamide treatment of nuclear extracts strongly reduces the binding of NFI proteins, and the addition of higher concentrations of dithiothreitol to nuclear extracts from TG-treated cells restores NFI-DNA binding to levels in extracts from untreated cells.

NFI proteins

TG

NFI-DNA


Input: LMP2A enhances Lyn and Syk ubiquitination in vivo in a fashion that depends on the activity of Nedd4 family members and correlates with destabilization of the Lyn tyrosine kinase.

Lyn

Syk

Lyn tyrosine kinase


Input: Further, Tax-mediated apoptosis was effectively prevented by ectopic expression of the p300 coactivator.

Tax

p300 coactivator


Input: Our results, however, were obtained for Z itself and not for [Z].


Input: Fisher' s exact test or Pearson' s chi2 test were used for statistical analysis.


Input: RESULTS: In the pregnant group, serum PP14 concentrations were markedly increased after ET, and a significant difference between the pregnant group and the nonpregnant group was observed 8 days following ET (p < 0. 01).


Input: High expression of the peroxisome proliferator-activated receptor alpha (PPARalpha) differentiates brown fat from white, and is related to its high capacity of lipid oxidation.

peroxisome proliferator-activated receptor alpha

PPARalpha


Input: This-2485/-2458 element bound PPARalpha and PPARgamma from brown fat nuclei.

PPARalpha

PPARgamma


Input: These results provide direct evidence for differential susceptibility to endonuclease-mediated mRNA decay resulting from the differential affinity of a RNA-binding protein for cis-acting stability determinants.


Input: RESULTS: Twenty-two (26%) patients had PHG before (group A) and 64 (74%) developed PHG after variceal eradication (group B).


Input: Response was extremely poor in African Americans and those with HCV genotype 1.


Input: Aspirin causes peptic ulcers predominately by reducing gastric mucosal cyclooxygenase (COX) activity and prostaglandin synthesis.

gastric mucosal cyclooxygenase

COX


Input: A total of 1060 clones were randomly selected for sequencing of one end.


Input: CONCLUSIONS: The surgical or multimodality treatment of MSGT has provided a good locoregional control (78%) and 68% 10-year survival in a series of patients treated at the oncology department of a general hospital in Quito, Ecuador.


Input: The gene is separated into four exons by three short introns, and the open reading frame consists of 6660 base pairs (bp) capable of encoding a polypeptide of 2220 amino acid residues.


Input: Like the p190-B exon, the first exon of p190-A is extremely large (3. 7 kb in length), encoding both the GTPase and middle domains (residues 1-1228), but not the remaining GAP domain, suggesting a high conservation of genomic structure between two p190 genes.

GTPase

GAP domain

p190 genes


Input: The entire human teneurin-1 (TEN1) gene is contained in eight PAC clones representing part of the chromosomal locus Xq25.

human teneurin-1


Input: The plexiform neurofibroma and multiple localized neurofibromas are characteristic of NF1.


Input: In general lookback, all patients who received blood before being tested for hepatitis C are advised to undergo testing.


Input: The proposed algorithm consists of several steps.


Input: It contained seven extra amino acids of FVVLNLQ; this short stretch of extra sequence was found between Gln (421) and Phe (422) within the SET (Suvar3-9, Enhancer-of-zeste, Trithorax) interacting domain (SID) of rMTM.

SET

Enhancer-of-zeste

Trithorax

rMTM


Input: MED1 has a weak glycosylase activity on the mutagenic adduct 3, N (4)-ethenocytosine, a metabolite of vinyl chloride and ethyl carbamate.

glycosylase


Input: There were no instances of major flap necrosis although two flaps showed tip ischaemia.


Input: These results suggest that XAB1 is a novel cytoplasmic GTPase involved in nuclear localization of XPA.

cytoplasmic GTPase

XPA


Input: One of these factors, IRF-2, was initially cloned as an antagonistic counterpart to IRF-1 with oncogenic potential.


Input: Among the total CDSs, 8. 8% match sequences of proteins found only in Bacillus subtilis and 66. 7% are widely conserved in comparison with the proteins of various organisms, including B. subtilis.


Input: Tobramycin-loaded SLN administered i. v. showed a prolonged circulation time compared to the i. v. administered tobramycin solution.


Input: Bacteriol.


Input: Terminal deoxynucleotidyl transferase-mediated nick end labeling assays revealed that hormonal activation of the PAX3 repressors induced extensive apoptosis that correlated with down-regulation of BCL-X (L) expression.

Terminal deoxynucleotidyl transferase

PAX3 repressors

BCL-X (L)


Input: VEGF promoter activity in transient transfections was decreased by either pharmacological or genetic inhibition of EGFR, Ras, or phosphatidylinositol 3'-kinase [PI (3) kinase].

VEGF promoter

EGFR

Ras

phosphatidylinositol 3'-kinase [PI (3) kinase]


Input: Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia.

Epidermal growth factor receptor

vascular endothelial growth factor

phosphatidylinositol 3'-kinase


Input: Thus, IHHNV is closely related to densoviruses of the genus Brevidensovirus in the family Parvoviridae, and we therefore propose to rename this virus Penaeus stylirostris densovirus (PstDNV).


Input: Stress-activated protein kinase 1 (SAPK1), also called c-Jun N-terminal kinase (JNK), becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses.

Stress-activated protein kinase 1

c-Jun N-terminal kinase

JNK


Input: Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation.

mitogen-activated protein (MAP) kinase phosphatase-1

p38 MAP kinase

p38 C-terminal domain


Input: Thus, the class C-Vps complex directs multiple reactions during the docking and fusion of vesicles with the vacuole, each of which contributes to the overall specificity and efficiency of this transport process.

class C

Vps


Input: Combined intravenous and intra-arterial recombinant tissue plasminogen activator in acute ischemic stroke.

tissue plasminogen activator


Input: Signal transduction via modulation of phosphorylation after selective inhibition of protein phosphatase (PP) 1 and/or PP2A appears to play a role in okadaic acid (OA)-mediated effects.

protein phosphatase (PP) 1


Input: Exon A is located approximately 7 kb 5' to the HSL translation start site.

HSL translation start site


Input: NF-kappaB is a redox-sensitive transcription factor known to be activated by oxidative stress as well as chemical and biological reductants.

NF-kappaB


Input: Cardiovascular risk factors and antihypertensive treatment.


Input: What to look for during a compliance review: 10 common mistakes made by SNFs.


Input: CONCLUSIONS: EBCT technology allows minimally invasive evaluation of intramyocardial microcirculatory function and permits assessment of microvascular BV distribution in different functional components.


Input: These two mAbs used the same V (H) and J (H) gene segments, but different D, Vkappa, and Jkappa genes.


Input: SSF experiments were carried out in bench-scale bioreactors (equipped with CO2 and volatile organic traps) containing a mixture of lignocellulosic materials and a radiolabeled pesticide.


Input: Characterization of a Xenopus laevis CXC chemokine receptor 4: implications for hematopoietic cell development in the vertebrate embryo.

Xenopus laevis CXC chemokine receptor 4


Input: Patients had to have adequate liver, renal, and marrow functions.


Input: Inhibition of RNA2 translation was selective, with no effect on general cellular translation or translation of BMV RNA1-encoded replication factor 1a, and was independent of p20, a cellular antagonist of DED1 function in translation.

replication factor 1a


Input: Abbreviations: CAS, CRK-associated substrate; CH, calponin-homology domain; CSK, C-terminal SRC kinase; E6, Papillomavirus E6 protein; FAK, focal adhesion kinase; GIT, GRK interacter; GPCR, heterotrimeric-G-protein-coupled receptor; GRK, G-protein-coupled-receptor kinase; MAPK, mitogen-activated protein kinase (ERK, p38, JNK); PAK, p21-activated kinase; PBS, paxillin-binding subdomain; PIX, PAK-interacting exchange factor; PKL, paxillin kinase linker; POR1, partner of Rac; PS, phosphoserine; PT, phosphothreonine; PY, phosphotyrosine; RTK, growth factor receptor tyrosine kinase; SH, SRC-homology domain.

CAS

CRK-associated substrate

CH

calponin-homology domain

CSK

C-terminal SRC kinase

Papillomavirus E6 protein

FAK

focal adhesion kinase

GIT

GRK interacter

GPCR

heterotrimeric-G-protein-coupled receptor

GRK

G-protein-coupled-receptor kinase

MAPK

mitogen-activated protein kinase

ERK

JNK

PAK

p21-activated kinase

PBS

paxillin-binding subdomain

PIX

PAK-interacting exchange factor

PKL

paxillin kinase linker

partner of Rac

RTK

growth factor receptor tyrosine kinase

SH

SRC-homology domain


Input: In 15 ventilator-dependent, SB, and actively expiring patients, we found that the difference PEEP (i), dyn-Pga, total decay (mean +/-SD, 5. 7 +/-1. 9 cm H (2) O) was quite similar to PEEP (i), dyn ref (5. 3 +/-1. 9 cm H (2) O).


Input: Of 208 eligible subjects, 82 received supervised IPT at a dose of 900 mg twice weekly for 6 mo (Regimen A), 73 received unsupervised IPT 900 mg twice weekly for 6 mo (Regimen B), and 53 received unsupervised IPT 300 mg daily for 6 mo (Regimen C).


Input: There were 122 cases of tuberculosis over an average 10. 3 yr of follow-up (crude annual incidence, 76. 2/100, 000).


Input: These results suggested that BACH1t recruits BACH1 to the nucleus through BTB domain-mediated interaction.

BTB


Input: Transcription of the six EBNA genes, which are expressed in EBV-immortalized primary B cells, arises from one of two promoters, Cp and Wp, located near the left end of the viral genome.

EBNA genes

Cp

Wp


Input: Thus, blocks in the RARalpha-specific pathway of retinoid-induced differentiation may be bypassed during retinoid induction of FR-beta expression.

RARalpha

FR-beta


Input: Is more better? About dose levels of ACE inhibitors in chronic heart failure.

ACE


Input: To test whether or not SOCS-3 also binds to the IGFIR, we cloned human SOCS-3 by reverse transcription-polymerase chain reaction from human skeletal muscle mRNA.

IGFIR

human SOCS-3


Input: A protein lacking the SH2 and RING finger domains has no activity, but a chimeric protein with the SH2 and RING finger domains of SLI-1 replaced by the equivalent domains of c-Cbl has activity.

c-Cbl