Input: We previously showed that v-Rel, the oncoprotein of the avian retrovirus Rev-T, can increase expression from promoters containing binding sites for the cellular transcription factor Sp1 in chicken embryo fibroblasts (S.

v-Rel


Input: Previous studies have demonstrated that the TATA element is critical for basal and Tat-induced HIV-1 gene expression.

Tat


Input: A comparison of the nucleotide sequence of the p54 gene carried by two virulent ASFV strains (E70 and E75) with that obtained from virus Ba71V showed 100% similarity.

p54 gene


Input: The p55 mRNA is undetectable in non-EBV-infected B-and T-cell lines or in a myelomonocytic cell line (U937).

p55 mRNA


Input: A simple registration as an incentive for improvement


Input: RESULTS: The diagnostic quality of FDG images was at least as good as that of their Tl-201 counterparts, with less liver background in all but one FDG study.


Input: The coordinated expression of CD4 and CD8 during T-cell development is tightly coupled with the maturation state of the T cell.


Input: The dying tTG-transfected cells exhibit both cytoplasmic and nuclear changes characteristic of cells undergoing apoptosis.

tTG


Input: Using an RNase H-mediated mapping technique, we show that the 64-kDa subunit of CstF can be photo cross-linked to pre-mRNAs at U-rich regions located downstream of the cleavage site of the simian virus 40 late and adenovirus L3 pre-mRNAs.

RNase H

CstF

adenovirus L3 pre-mRNAs


Input: The protein encoded is 114 kDa and contains eight zinc finger motifs, seven of which are present in two clusters at opposite ends of the molecule.


Input: Tissue-specific expression of the diazepam-binding inhibitor in Drosophila melanogaster: cloning, structure, and localization of the gene.

diazepam-binding inhibitor


Input: Using a v-erbA probe, we obtained a cDNA which encodes a novel 445-amino-acid protein, RLD-1, that contains the characteristic domains of nuclear receptors.

v-erbA


Input: Only two of the isoforms possess the N-terminal zinc finger domain that is necessary and sufficient for TdT promoter binding.

TdT promoter


Input: This study provides direct evidence that USF, a member of the basic helix-loop-helix leucine zipper family, binds to MLE1, HF-1a, and PRE B sites and suggests that it is a component of protein complexes that may coordinately control the expression of MLC-2v and alpha-myosin heavy-chain genes.

USF

basic helix-loop-helix leucine zipper family

PRE B sites

alpha-myosin heavy-chain genes


Input: Activation of c-fos gene expression by a kinase-deficient epidermal growth factor receptor.

c-fos gene

epidermal growth factor receptor


Input: Because endogenous HSF DNA-binding activity is low and anti-hHSF1 antibody does not recognize Xenopus HSF, we employed this system for mapping regions in hHSF1 that are required for the maintenance of the monomeric state.

HSF

anti-hHSF1 antibody

Xenopus HSF


Input: Enhancers containing disrupted Ets-1 binding sites were tested in transient expression assays in the murine T-cell line EL4. E1; alterations in the LVb element affected constitutive enhancer activity, while mutation of either the LVb or LVc element disrupted phorbol ester-induced enhancer activity.

Ets-1 binding sites


Input: The predominant binding activity was not Ets-1 but rather two independent DNA-protein complexes that comigrated in mobility shift assays.


Input: Treatment with amphotericin B and flucytosine led to improvement of the symptoms but did not eradicate the micro-organisms from the cerebrospinal fluid (CSF).


Input: The unexpected presence of the tRNA (trp) (CCA)-gene transcript in mitochondria is also reported.

tRNA (trp) (CCA)-gene transcript in mitochondria


Input: The parameters of nonspecific humoral immunity--serum immunoglobulins and immune complexes--were evaluated in irradiated group of patients with uterine cervix carcinoma (Stages IIB and IIIB), during one year follow up.

serum immunoglobulins


Input: Mutation of KRKR to NGER retains MO15 in the cytoplasmic compartment, whilst the wild-type protein is detected exclusively in the nucleus.


Input: To confirm the binding of protein to these sites in cells, we carried out an in vivo genomic footprinting analysis of this portion of the TGF alpha promoter in normal and transformed rat liver epithelial cell lines that express the endogenous gene at varying levels.

TGF alpha promoter


Input: Strikingly, this subdomain is also present in the otherwise unrelated N-terminal activating region of p58c-ets-2 and was thus named BEC for Ets-1-beta/Ets-2-Conserved sequence.

BEC

Ets-2-Conserved sequence


Input: This work unravels a new model for the ets-1/ets-2 gene' s evolution, based for the first time on both structural and functional evidences.

ets-2 gene


Input: The v-ets oncogene of the avian retrovirus E26 differs from its cellular progenitor p68c-ets-1 by two amino acid substitutions (alanine 285 and isoleucine 445 in c-ets-1 both substituted by valine in v-ets, mutations A and B respectively) and its carboxy-terminal end (mutation C).

v-ets oncogene

v-ets


Input: Consequently functional mRNAs can be produced by endogenous RNA polymerase I.

endogenous RNA polymerase


Input: The individual subunits of Ku have been difficult to isolate from human cells without denaturation and attempts to produce functional recombinant Ku have been largely unsuccessful.

Ku

functional recombinant Ku


Input: Using this method, we were able to select strong enhancer-type activation domains from the immediate early regions of two herpesviruses, namely pseudorabies virus and bovine herpesvirus 1.

immediate early regions


Input: A genetic system was devised to select for pi protein mutants which discriminate between IR and DR (York et al., Gene (Amst.) 116, 7-12, 1992; York and Filutowicz, J.

pi protein mutants


Input: Univariate statistical analysis based on Kaplan-Meier-estimates and Log-Rank-Test showed the following prognostically beneficial factors: Limited disease stage (p = 0. 009), NSE serum level less than 25 micrograms/l (p = 0. 016), serum alkaline phosphatase less than 200 U/l (p = 0. 035), normal serum albumin (p = 0. 003) and activity index of minimum of 70 (p < 0. 001).

NSE

alkaline phosphatase

albumin


Input: HBx strongly elevates levels of GTP-bound Ras, activated and phosphorylated Raf, and tyrosine-phosphorylated and activated MAP kinase.

HBx

Ras

Raf

MAP kinase


Input: Role of c-myc in simian virus 40 large tumor antigen-induced DNA synthesis in quiescent 3T3-L1 mouse fibroblasts.

c-myc

simian virus 40 large tumor antigen


Input: Laser therapy of penile carcinoma


Input: A 15. 1 kb fragment of the yeast genome was allocated to the centromeric region of chromosome XIV by genetic mapping.


Input: A third one is homologous in half of its length to the prokaryotic hydantoinase HyuA and in the other half to hydatoinase HyuB.

prokaryotic hydantoinase HyuA

hydatoinase HyuB


Input: It was shown that estradiol concentrations obtained after estradiol valerate and micronized estradiol ingestion were dependent on the patient' s age as well as on the constitutional type.


Input: Constipation is not a risk factor for hemorrhoids: a case-control study of potential etiological agents.


Input: Of 419 persons surveyed, 207 (49. 4%) were antigen-positive with the Og4C3 assay.


Input: Vibrio cholerae O139 in Calcutta.


Input: Sequence analysis of the zebrafish egr1 coding region revealed a high level of homology to the mouse, rat, and human Egr1 genes with the notable exception of a polymorphic, triplet nucleotide repeat sequence in the region coding for the amino terminus of the Egr1 protein.

zebrafish egr1 coding region

human Egr1 genes

Egr1 protein


Input: The fibrinogen, serum proteins, sodium heparin and membrane contributed to Cm by 20%, 14%, 2% and 64%, respectively.

fibrinogen


Input: In these vectors the chimeric long terminal repeat (chLTR) drives the expression of the chloramphenicol acetyl transferase (CAT) reporter gene that is followed by an internal SV40 virus early region promoter linked to the neomycin phosphotransferase II (NEO) gene.

chimeric long terminal repeat

chLTR

chloramphenicol acetyl transferase

CAT

SV40 virus early region promoter

neomycin phosphotransferase II

NEO


Input: Optima) genomic library by hybridizing with elicitor-induced stilbene synthase cDNA as a probe.

stilbene synthase cDNA


Input: A total of 125 acute leukemia adult patients were autografted with bone marrow (BM) purged by mafosfamide (ASTA Z) during the period of January 1983 to January 1993.


Input: The pretransplant regimen consisted of cyclophosphamide (120 mg/kg) and total body irradiation.


Input: The site-directed mutation of the kappa B motif in IL-6/CAT plasmid resulted in the complete abrogation of IL-6 promoter activity in these cells.

kappa B motif

CAT

IL-6 promoter


Input: Curiously, testololactone was earlier and more widely used than aminoglutethimide in treating advanced breast carcinoma.


Input: Use of the vena cava to extend the right renal vein for cadaver transplantation is controversial.


Input: Enhanced hepatic portal blood flow induced by prostaglandin E1 following liver transplantation in pigs.


Input: One gene appears ubiquitously expressed while the other is prominently expressed in muscle.


Input: For HeLa, 293, U937, and A549 cells, participation of E2F-1, DP-1, cyclin A, and RB was involved in formation of some complexes only, assuming participation of factors different from E2F-1 or DP-1 in others.

cyclin A

RB


Input: E1A autoactivation mediated by these sites was about twofold compared with a ninefold activation described for the complete E1A promoter.

E1A promoter


Input: Cestode invasion in irradiated host organism increases the negative effect of ionizing radiation on the hamster immune system.


Input: During heat exposure, chicks that had been subjected to early 60% restriction with non-metyrapone-treated food had lower H/L ratios and improved resistance to marble spleen disease infection.


Input: Analyses of additional tumors induced in mice from two reciprocal crosses, A/J x C3H/HeJ F1 (hereafter called AC3F1) and C3H/HeJ x A/J F1 (hereafter called C3AF1), provided evidence for the inactivation of one allele of the putative chromosome 4 tumor suppressor gene by parental imprinting.


Input: ERV1 is involved in the cell-division cycle and the maintenance of mitochondrial genomes in Saccharomyces cerevisiae.


Input: Lesion diameters of greater than 20 mm and the large sessile-type configurations were factors that were associated with incomplete removal.


Input: Routinely collected, processed and stored breast cancer tissue blocks recovered from the archives of the Pathology laboratory in Dar es Salaam after storage of up to 3 years were analysed by a flow cytometry for DNA ploidy and S-phase fraction.


Input: Cbf3 contains three proteins, Cbf3a, Cbf3b and Cbf3c.


Input: Such an interaction could be detected using a GST-POU fusion protein bound to glutathione-agarose beads.

GST

POU


Input: These mutations are localized in the same region where the HSV transactivator VP16 binds, but did not coincide with the VP16 contacts.

HSV transactivator VP16


Input: Notably, these residues are located in different domains.


Input: However, rapamycin inhibited proliferation of Ba/F3-EpoRgp55 but not of MEL cells despite inhibition of p70 S6 kinase activity in both cells.

p70 S6 kinase


Input: Intraventricular injection of (2S, 1' R, 2' R, 3' R)-2-(2, 3-dicarboxycyclopropyl) glycine (DCG-IV), a potent agonist for metabotropic glutamate receptors, to rats retarded dose-dependently the recovery from halothane anesthesia at a dose range from 30 to 300 pmol/rat.

glutamate receptors


Input: The hepatocyte nuclear factor-3 (HNF-3)/forkhead (fkh) proteins consist of an extensive family of tissue-specific and developmental gene regulators which share homology within the winged helix DNA binding motif.

hepatocyte nuclear factor-3

forkhead

fkh


Input: Interestingly, dTFIIA-L/S is also able to significantly enhance transcriptional activation by upstream transcription factors including Sp1, VP16, and NTF-1.

dTFIIA-L/S


Input: In particular, changes in intracellular Ca2 + have the potential to either inhibit or augment the ability of cAMP to stimulate transcription, depending on the presence of specific forms of Ca2 +/calmodulin-dependent protein kinases.

Ca2 +/calmodulin-dependent protein kinases


Input: Antibodies directed against the SNM1 protein immunoprecipitated RNase MRP RNA from whole-cell extracts without precipitating the structurally and functionally related RNase P RNA.

SNM1 protein

RNase MRP RNA

RNase P RNA


Input: Our results show that the ORF of hAMPK encodes 552 amino acids (aa) (62. 250 kDa) and is highly conserved with rAMPK with identities of 97. 3 and 90% at the aa and nt levels, respectively.

hAMPK

rAMPK


Input: In human brain, contactin was first identified by amino terminal and peptide sequencing of the lentil-lectin-binding glycoprotein Gp135.

contactin

lentil-lectin-binding glycoprotein Gp135


Input: The centromeric YAC contig, which consists of 23 overlapping YACs and orders 19 sequence-tagged sites (STSs), covers a minimum of 2. 2 Mb and spans the Ewing sarcoma breakpoint. c-ets 1 and Fli-1, two members of the ets family, have been linked within 400 kb of intervening DNA within this contig, which also comprises a polymorphic microsatellite, D11S912 (CA) n, which we have localized within the Fli-1 gene.

c-ets 1

ets family

Fli-1 gene


Input: A cDNA for a newly discovered pseudogene, closely related to the mouse mast cell chymases was isolated by polymerase chain reaction amplification from a mouse connective tissue-like mast cell line.

mouse mast cell chymases


Input: IFI16 consists of ten exons and nine intervening introns spanning at least 28 kilobases (kb) of DNA.


Input: Courses were repeated every four weeks.


Input: Peter Elfer explores the implications of the ruling.


Input: Other adverse events with incidences significantly higher than with placebo were dizziness, constipation, sweating, nervousness, and abnormal ejaculation.


Input: Homology was also detected between the putative transit peptide sequence of cysteine synthase C and other mitochondrion-targeting leader sequences.

cysteine synthase C


Input: Furthermore, our data also show that, in addition to TEF-1, another HF-1a-related factor may be recognized by the alpha-MHC gene EM element.

HF-1a-related factor

alpha-MHC gene


Input: Rat kidney carboxylesterase.

Rat kidney carboxylesterase


Input: Recombinant I-kappa B alpha inhibited kappa B motif binding by nuclear factor-kappa B1, RelA, and c-Rel as indicated by studies using UV radiation-induced covalent cross-linking to a bromodeoxyuridine-substituted kappa B oligonucleotide.

Recombinant I-kappa B alpha

kappa B motif

nuclear factor-kappa B1

RelA

c-Rel

kappa B oligonucleotide


Input: The physical and chemical stability of a combination of drugs commonly administered into the epidural or intrathecal space for the treatment of chronic pain was investigated.


Input: Therefore, mechanisms that control activation of the MAP kinase cascade temporally and spatially may be important for specification of cellular responses.

MAP kinase


Input: A candidate gene for Bcg, designated natural resistance-associated macrophage protein (Nramp), has been isolated and shown to encode a novel macrophage-specific membrane protein, which is altered in susceptible animals.

Bcg

natural resistance-associated macrophage protein

Nramp


Input: This motif is similar to but distinct from the LIM domain and the RING finger family, and is reminiscent of known metal-binding regions.

LIM domain

RING finger family


Input: The P131 ORF is followed in-frame by a second ORF which is probably expressed by partial readthrough of the UGA termination codon of the P131 ORF to produce a polypeptide of M (r) 191044 (P191).


Input: One hundred fifty patients were reviewed at 1 year after arthroplasty.


Input: Elementary visual hallucinations in migraine and epilepsy.


Input: The influence of patient-related factors on inter-observer variability in the evaluation of neurological signs was investigated.


Input: The defined length of the mRNA, 1, 838 nucleotides, was in agreement with that of a 1. 9-kb RNA expressed throughout the replication cycle, starting at the early stages of infection.


Input: Infect.


Input: Transient transfections of a construct expressing the RNA transcript defined by clone B1. 1 into D17 cells led to the expression of an Env/Mlvi-4 fusion protein with an apparent molecular mass of 33 kDa.

Env


Input: Roizman, J.


Input: Articles addressing valvular heart disease or heart failure secondary to acute myocardial infarction or Chagas' disease were excluded.


Input: All nuclear receptors have several well-characterized structural domains, including a conserved DNA-binding domain, and a ligand binding domain at the carboxyl terminus of the receptor.


Input: The sample includes all the HIV-infected-patients continuously referred to the Outpatient Service of the Infectious Diseases dept. of Bologna' s " Ospedale Maggiore " General Hospital during some five days (19-23rd, July 1993).


Input: Using in organello footprint analysis, we demonstrate that within human placental mitochondria there is a high level of protein-DNA binding at regularly phased intervals throughout a 500-bp region encompassing the D-loop DNA origins and two promoter regions.


Input: The Nur77 protein can act as a potent transcription activator and may function to regulate the expression of downstream genes in response to extracellular stimuli.

Nur77 protein


Input: One class of plasmids contained tRNA (His) genes and conferred efficient suppression only when cells were starved for histidine; these plasmids suppressed a gcn2 deletion much less efficiently than they suppressed gcn2-507.

tRNA (His) genes


Input: Thus, the presence of the Cln2 PEST domain was sufficient to destabilize a heterologous protein.

Cln2 PEST domain


Input: Electrophoretic mobility shift assays with each of these sequences demonstrated complexes with mobilities identical to those of the NF-kappa B site from the kappa light-chain gene.

NF-kappa B site

kappa light-chain gene


Input: Although a carboxyl-terminal HSF transcriptional activation domain is critical for the activation of CUP1 transcription in response to both heat shock stress and glucose starvation, this region is dispensable for transient heat shock activation of at least two genes encoding members of the S. cerevisiae hsp70 family.

HSF

hsp70 family


Input: We have recently detected high levels of CKB mRNA in HeLa cells and, in this study, have tested whether this may be due to the extremely low amounts of p53 protein present in HeLa cells.

CKB mRNA

p53 protein


Input: Distal lower motor neuron syndrome with high-titer serum IgM anti-GM1 antibodies: improvement following immunotherapy with monthly plasma exchange and intravenous cyclophosphamide.

serum IgM anti-GM1 antibodies


Input: Regulators responsible for the pervasive, nonsex-specific alternative pre-mRNA splicing characteristic of metazoans are almost entirely unknown or uncertain.


Input: A normal systemic response was obtained after IF, indicating that rhG-CSF retains activity in the solid state.

rhG-CSF


Input: PAI-1 levels increased significantly in patients who received iohexol but not in those who received ioxaglate.


Input: Determination of potassium iodide in Polish edible salt


Input: The recovery value of systolic pressure was higher than diastolic pressure and pulse pressure increased.


Input: The importance of hepatitis C virus (HCV) infection as a cause of chronic liver disease has become clear with the introduction of serologic detection methods.


Input: Human adenovirus type 41 contains two fibers.


Input: Outflow obstruction of pancreatic juice, i. e., " relative stenosis of the minor papilla, " was considered to be present in the patients with type II papilla, and, therefore, the patients with type II papilla might suffer from acute pancreatitis resulting from poor drainage of pancreatic juice and excessive pressure in the dorsal duct.


Input: Sequencing of the TP53 transcripts from exons 2 to 10, however, did not reveal mutations of the remaining allele in any of these tumors.

TP53 transcripts


Input: An unusual complication in an unsuitable patient.


Input: In the ISO group, at pre-DEX, CBF increased from 86 +/-8 to 166 +/-19 mL. min-1. 100 g-1 in response to hypercapnia (PCO2 approximately 90 mmHg). (ABSTRACT TRUNCATED AT 250 WORDS)


Input: All other ejaculate parameters (density, motility, swelling test, penetration test) remained unchanged, and there was only one post-therapeutic pregnancy.


Input: KRN2391 and cromakalim produced a dose-dependent increase in aortic and coronary blood flow.


Input: In H4IIE rat hepatoma cells, glucocorticoids, retinoic acid and cyclic AMP (cAMP) increase PEPCK gene transcription whereas insulin and phorbol esters have the opposite effect.

PEPCK gene

insulin


Input: Acta 572, 113-120].


Input: Basal plasma AVP levels and AVP release after postural change were assessed, and plasma NPY levels were measured in the same samples.

AVP

AVP

NPY


Input: A stretch of 16 nucleotides just upstream of the IL-4RE contributed to IL-4 inducibility and formed nucleoprotein complexes with constitutive factors.


Input: Our previous study suggested that pertussis toxin (IAP)-sensitive GTP-binding protein (s) (G-protein) is involved in the process of differentiation by hormones/IBMX, accompanied by c-fos induction.

pertussis toxin

IAP

GTP-binding protein (s)

G-protein

c-fos


Input: ATX, like PC-1, was found to hydrolyze the type I phosphodiesterase substrate p-nitrophenyl thymidine-5'-monophosphate.

ATX

type I phosphodiesterase


Input: The effect of site-specific mutations in the mouse platelet-derived growth factor (PDGF) beta-receptor on activation of the Na +/H + exchanger was examined in normal murine mammary gland epithelial (NMuMG) and Chinese hamster ovary (CHO) cells.

mouse platelet-derived growth factor (PDGF) beta-receptor

Na +/H + exchanger


Input: Sequence analysis revealed: 1) a kinase catalytic domain most characteristic of serine/threonine kinases but hybrid between members of the family of microtubule-associated protein kinase kinase kinases and the fibroblast growth factor receptor family; 2) two putative alpha-helical leucine zipper motifs separated by a 25-amino acid charged intermediate segment but lacking an NH2-terminal basic domain; and 3) COOH-terminal and NH2-terminal proline-rich domains suggestive of src homology 3 (SH3) domain binding regions.

serine/threonine kinases

microtubule-associated protein kinase kinase kinases

fibroblast growth factor receptor family

src homology 3


Input: Type 2 genomes containing this sequence presumably more closely reflect the structure of the infectious, replication-competent retrovirus ancestors of the HERV-K family than do type 1 genomes that lack the sequence.


Input: However, when domain I and domain II were linked on the same plasmid, high levels of replication were observed.


Input: Point mutations that suppressed the in vitro binding of NF-Y to the internal palindromic arm reduced the activity of the resident P4 promoter, while those preventing complex formation with USF did not, as determined by transient expression assays using the luciferase reporter gene.

NF-Y

USF

luciferase


Input: Surprisingly, nuclear forms of IE110 were found to move a cytoplasmic form of IE175 into nuclear punctate structures, and a cytoplasmic form of IE110 was able to retain nuclear forms of IE175 in cytoplasmic punctate structures.


Input: Transcription of the gene for ivanolysin O and expression of other genes of the virulence gene cluster in L. ivanovii were dependent on PrfA.

ivanolysin O

virulence gene cluster in L. ivanovii

PrfA


Input: Moreover, by complementation of the WA fyuA mutant by the cloned fyuA gene, yersiniabactin uptake and mouse virulence were restored.

WA fyuA mutant

fyuA gene


Input: The ICBF in the ischaemic cortex revealed a graded reduction from the ischaemic centre to the surrounding tissues.


Input: The treatment of hydronephrosis in children


Input: The inflation hub of the probe is recreated by modifying a standard USCI Tuohy-Borst Y adaptor and attaching this to the transected probe hypotube.


Input: The other element bound RBP-J kappa with low affinity.

RBP-J kappa


Input: The basal promoter strength of constructs that contained deletions in the U5 region of the LTR was analyzed by chloramphenicol acetyltransferase (CAT) assays following transfection of HeLa cells or Jurkat T-cells in the presence or absence of viral transactivator tax protein.

U5 region

chloramphenicol acetyltransferase

CAT

tax


Input: In reviewing a number of the most intensely studied environmentally inducible promoters it becomes clear that the presence of two cis-acting elements are critical for promoter activity, one of which is the G-box (CCACGTGG).


Input: Recently, a protein designated GF14 has been isolated that is associated with the GBF protein complex.

GBF protein complex


Input: New diagnostic strategies for lupus anticoagulants and antiphospholipid antibodies.


Input: Propafenone is well tolerated in the majority of young patients.


Input: Mutational analysis of yeast CEG1 demonstrated that four of the five conserved motifs are essential for capping enzyme function in vivo.

yeast CEG1

capping enzyme


Input: 2 patients (11%) had significant morbidity 502 and 529 days respectively after transplantation.


Input: Alternative splicing of the cytoplasmic tail appears to generate multiple PECAM-1 isoforms that may regulate phosphorylation, cytoskeletal association, and affinity modulation of the mature protein.

PECAM-1 isoforms


Input: Transfer also correlated inversely with gastric juice pH (r =-0. 619, P < 0. 02).


Input: This technique has a sensitivity and a specificity of almost 100%, and is currently the best way to diagnose nodal involvement, apart from laparotomy.


Input: The data show conclusively that phosphorylation of His-304 is not essential for any of the known functions of A. vinelandii NifL.

A. vinelandii NifL


Input: If this is present, such patients should be closely monitored, and any atypical lesions biopsied.


Input: Cumulated maximum lod scores between FRDA and D9S5 and between FRDA and D9S15 are above 36 and 61, respectively, at a recombination fraction of 0, indicating that recombination events needed to orient the search of the gene are very difficult to identify and ascertain.

FRDA

FRDA


Input: A receptor-like protein kinase, OsPK10, has been cloned from rice (Oryza sativa).

receptor-like protein kinase


Input: A sequence representing about 50% of the expected complete sequence was obtained by translation of the two open reading frames present on a 1. 6 kb DNA genomic fragment.


Input: Goodpasture' s-like syndrome and effect of extracorporeal membrane oxygenator support.


Input: A cDNA clone pCZ1, with a 1. 1 kb insert, was isolated from a NaCl-adapted tobacco cell cDNA library that encodes an apparently full-length 29 kDa protein (251 amino acids) with a calculated pI of 5. 7.


Input: METHODS--16 volunteered for spirometry with methacholine provocation test including a test for small airways function by volume of trapped gas (VTG).


Input: Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK.

CDK-activating kinase

RNA polymerase II

TFIIH

TFIIK


Input: These same regions showed remarkable homology to two invertebrate proteins, CNC and skin-1, postulated to regulate embryonic development in Drosophila melanogaster and Caenorhabditis elegans, respectively.

CNC


Input: DNA sequence analysis has confirmed that this mutation affects the C-terminal region of the alpha subunit, changing a leucine residue at position 290 to a histidine (rpoAL290H).


Input: CONCLUSIONS: These findings indicate a physical barrier of oesophageal surfactant which could offer some degree of protection against gastro-oesophageal reflux but one which is particularly prone to attack by bile.


Input: Differential screening of mitochondrial cDNA libraries from male-fertile and cytoplasmic male-sterile sugar-beet reveals genome rearrangements at atp6 and atpA loci.

atpA loci


Input: The effects of social isolation on morphine-induced locomotor activity were compared in: (i) animals with an intact hypothalamo-pituitary-adrenal (HPA) axis; (ii) animals in which stress-induced corticosterone secretion was blocked by adrenalectomy.


Input: Using this reporter gene system, we previously showed that EPO-induced activation of the c-fos promoter can be detected rapidly and sensitively as an elevation of cellular luciferase activity.

EPO

c-fos promoter

cellular luciferase


Input: I hypothesize that white gene expression from P [en] is repressed by the formation of a protein complex which is initiated at the engrailed PS sites and also requires interactions with flanking genomic DNA.

white gene

P [en]

engrailed PS sites


Input: SPP41 was cloned and sequenced and found to be essential. spp43 is allelic to the previously identified suppressor srn1, which encodes a negative regulator of gene expression.

suppressor srn1


Input: Standard curve correlation coefficients of 0. 995 or greater were obtained during validation experiments and analysis of study samples.


Input: To see if a pulse oximeter can monitor the fetus during labour we recruited 100 Caucasian women in normal uncomplicated labour.


Input: There was no difference in plasma concentrations of PGI2 (figure 4) and TxA2 in patients with normal blood pressure, mild preeclampsia and hypotension, whereas in severe preeclampsia, the plasma concentration of PGI2 was significantly lower (p < 0. 001) and of TxA2 significantly higher (p < 0. 001).


Input: A causal analysis of secondary variables showed that the formation of FB memories was primarily associated with the level of importance attached to the event and level of affective response to the news.


Input: The IPL1 gene is required for high-fidelity chromosome segregation in the budding yeast Saccharomyces cerevisiae.

IPL1 gene


Input: The complete gene organization was obtained by combining the results of the sequence of these clones and those of the characterization of polymerase chain reaction-amplified genomic segments.


Input: INO2, a regulatory gene in yeast phospholipid biosynthesis, affects nuclear segregation and bud pattern formation.


Input: The pentafluorobenzyl derivative of clonidine yields an intense ion fragment at m/z 354, and the lower limit of detection is 0. 025 ng/ml for a 1-ml plasma sample.


Input: Mammalian ABPs and SHBGs bind sex steroids with high affinity, but some binding properties differ among species.

Mammalian ABPs

SHBGs


Input: Src homology (SH) domain dependent protein-protein interactions are important to tyrosine kinase receptor signal transduction.

Src homology

SH

tyrosine kinase receptor


Input: Sample treatment was optimized in order to achieve a complete extraction of labetalol diastereoisomers and to avoid racemization during extraction.


Input: Under resting conditions, activity levels of cardiac vagal and sympathetic outflows are not related across young, healthy human subjects and peripheral interaction is not manifest between the autonomic divisions.


Input: Both proprioceptive and electroreceptive units showed a progression of receptive fields from anterior to posterior body in the rostral to caudal direction along the length of DGR.


Input: In control patients, baseline images presented Type I in 25, Type II in 7, and the Type III & IV in 0, and the Type after loading was the same as the Type at baseline.


Input: A more complete analysis of dose response, time and mode of Ga administration (preinjury or postinjury), and availability of Ga across the blood-brain barrier is needed to further evaluate the efficacy of this compound.


Input: The presence of regulatory sequences for the binding of transcription factors such as NF-kappa B and AP-2, whose activation is associated with the immediate response of the cell to an injury, may be an indication of the important role which HO-1 may play in defense mechanisms against tissue injury.

NF-kappa B


Input: Granisetron, but not saline, abolished vomiting and nausea when given as intervention after this combined emetic regimen.


Input: The femoroarterial coronary sinus difference in lactate turned negative, and pH, PCO2 and potassium differences increased in group 2 during pacing.


Input: This was obtained with the thermal neutron fluency 2. 0 x 10 (10) n/cm2.


Input: Endotoxemia induced by gram-negative bacteria leads to endotoxic shock pathogenetically stemming from the integral component of the bacterial wall--lipid A.


Input: The study made to define the ability of lipid A monoclonal antibodies to correct hemodynamic disturbances due to endotoxemia in dog experiments showed the efficacy of the antibodies administration.

lipid A monoclonal antibodies


Input: A randomised, controlled trial was undertaken in 40 patients with active Crohn' s disease to evaluate clinical and nutritional outcomes after an amino acid based diet containing 3% fat was given by a feeding tube compared with a peptide based diet containing 33% fat.


Input: The sequenced genomic region thus accounts for essentially all of the longest known transcript (4. 5 kb), although the precise ends of this transcript have not been defined.


Input: The pexB upstream region contained 245 nucleotides within which sequences approximating the consensus for cyclic AMP receptor protein and integration host factor binding sites were discernible.

pexB upstream region

cyclic AMP receptor protein

integration host factor


Input: The fepA-entD and fes-entF operons in the enterobactin synthesis and transport system are divergently transcribed from overlapping promoters, and both are inhibited by the Fur repressor protein under iron-replete conditions.

fepA

entD

fes

entF

Fur repressor protein


Input: Sequence analysis of a 6. 3-kbp genomic EcoRI-fragment of Alcaligenes eutrophus, which was recently identified by using a dihydrolipoamide dehydrogenase-specific DNA probe (A.

EcoRI

dihydrolipoamide dehydrogenase


Input: Using a previously published two-frequency (AC excitation) three-electrode method, the admittance locus plot (ALP) in the low-frequency region (< 1000 Hz) has been shown to be very well approximated by a straight line and can be described with frequency-independent parameters; phase angle alpha pi/2, conductance at extrapolated zero frequency G0 = 1/R0, and ion relaxation time tau.


Input: Intraoperative measurement of activated partial thromboplastin time and prothrombin time with a new compact monitor.

thromboplastin

prothrombin


Input: In addition, we sought to test the hypothesis that, when equal volumes are administered intrathecally, significant differences exist in the potential to three commonly used anesthetic solutions to induce sensory impairment.


Input: In an in vitro study, 10/0 nylon was found to require a significantly lower laser energy density to produce suture lysis following a single shot than either 10/0 Dacron or 10/0 prolene.


Input: The proteins encoded downstream of rpoN are known to negatively regulate sigma 54 activity.

rpoN

sigma 54


Input: We report here that microinjection of an anti-CBP antiserum into fibroblasts can inhibit transcription from a cAMP responsive promoter.

anti-CBP antiserum


Input: These results demonstrate that a class of proline-rich activator proteins and RNA polymerase II possess a common structural and functional component which can interact with the same target in the general transcription machinery.

RNA polymerase II


Input: Cloning of higher plant omega-3 fatty acid desaturases.

higher plant omega-3 fatty acid desaturases


Input: 65, 3829-3838, 1991), a truncated form of the IE polypeptide lacking IE amino acid residues 1-322 (and, therefore lacks the deduced transcriptional activation domain), fails to transactivate the EHV-1 tk promoter, but retains the ability to down-regulate the EHV-1 IE promoter.

IE polypeptide

IE amino acid residues 1-322

EHV-1 tk promoter

EHV-1 IE promoter


Input: CONCLUSION: Human preterm birth is associated with significantly lower progesterone/17 beta-estradiol ratios than those of women with preterm labor delivered at term.


Input: In conclusion, the disposition of venlafaxine and O-desmethylvenlafaxine is markedly altered in renal disease; therefore dosage adjustment is warranted for patients with creatinine clearance values below 30 ml/min.


Input: The availability of sequence from multiple species has permitted us to determine that the UBE site has close similarity to motifs that bind members of the NF-1 family of transcription factors.

NF-1 family of transcription factors


Input: The incidence of HSV-2 positive subjects (HSV-2/HSV-1 antibody ratio > or = 1) was low in the Jewish Israeli population, compared to other demographic areas.

HSV-2/HSV-1 antibody


Input: The mechanism whereby zeta PKC regulates NF-kappa B most probably involves the activation of a putative I kappa B kinase of molecular mass approximately 50 kDa, which phosphorylates and inactivates I kappa B.

zeta PKC

NF-kappa B

I kappa B kinase

I kappa B


Input: Stable expression of truncated inositol 1, 4, 5-trisphosphate receptor subunits in 3T3 fibroblasts.

truncated inositol 1, 4, 5-trisphosphate receptor subunits


Input: We report the identification and characterization of myr 4 (myosin from rat), the first mammalian myosin I that is not closely related to brush border myosin I.

myr 4

myosin from rat

mammalian myosin I

myosin I


Input: M., and D.


Input: In addition, computer analysis suggests that sequences similar to the A stem element are present within the three AAV promoter regions.

AAV promoter


Input: At least some of the difference in stability of the two kinds of complexes was due to the fact that the dissociation rate of the A stem substrate from the protein-DNA complexes was approximately fourfold faster than that of the complete TR.

TR


Input: Processing of the NS3'-5B polyprotein was complex and occurred rapidly.


Input: However, each promoter activated by IEP86 was synergistically affected by the addition of IEP72.


Input: 32Pi labeling or isoelectric focusing analysis of eIF-2 alpha from conditional casein kinase II mutants indicated that phosphorylation of eIF-2 alpha is abolished or dephosphorylated forms of eIF-2 alpha are detected when these strains are grown at the restrictive growth conditions.

eIF-2 alpha

casein kinase II mutants

eIF-2 alpha

eIF-2 alpha


Input: The R2 region within the class I enhancer acts as a negative element in Ad12-transformed cells and exhibits a stronger binding activity than is observed in nontumorigenic Ad5-transformed cells, which are not reduced in class I expression.


Input: PURPOSE: To evaluate the kinetics of erythropoietin (EPO) production and address the pathogenesis of anemia of prematurity, we measured EPO levels in infants during the first year of life.

erythropoietin

EPO

EPO


Input: The nerve growth factor beta gene (NGFB) belongs to a conserved syntenic group on human chromosome 1 and mouse Chromosome 3.

nerve growth factor beta gene

NGFB


Input: Furthermore, an upstream element, collagen element I (-370/-344), which shares homology with the LAP binding cis-element of the albumin promoter (9 of 13 bp) is described.

collagen element I (-370/-344)

LAP

albumin promoter


Input: Number and size of silver-stained nucleoli (Ag-NOR clusters) in canine seminomas: correlation with histological features and tumour behaviour.


Input: We speculate that mast cell degranulation may be involved in the pathogenesis of necrobiosis by altering fibroblast enzyme activity and/or producing prolonged inflammatory reactions.


Input: Molecular cloning of a cysteine synthase cDNA from Citrullus vulgaris (watermelon) by genetic complementation in an Escherichia coli Cys-auxotroph.

cysteine synthase cDNA


Input: In earlier studies we identified several regulatory elements that control transcriptional activation and aerobic repression of one of these genes, COX5b.


Input: Although elevated serum levels of antibodies to the nicotinic acetylcholine receptor (nAChR) have been reported in neuroleptic treated patients with tardive dyskinesia, such antibodies have not been determined in comparable nondyskinetic patients.

nicotinic acetylcholine receptor

nAChR


Input: The tumor suppressor and transcriptional factor p53 is a phosphorylated protein.


Input: This DNA containing promoter activity has been sequenced in its entirety and found to contain multiple putative regulatory sites.


Input: However, Southern blot and karyotype analyses did not reveal any significant changes in copy number or gross rearrangements of the p53 gene in any of the p53-cell lines.

p53 gene


Input: HupI showed strong identity to rubredoxin and rubredoxin-like proteins from many other bacteria.

HupI

rubredoxin

rubredoxin-like proteins


Input: The PCr resynthesis rate (P < 0. 01) and the effective maximal rate of mitochondrial ATP synthesis (P < 0. 05) also improved.


Input: An examination was performed in 15 patients who had developed pronounced osteomalacia following gastric resection.


Input: However, regional MVO2 increased to about the same extent in the CFX (from 6. 0 +/-0. 7 to 12. 4 +/-0. 9 ml O2. min-1 times 100 g-1) and the LAD region (from 7. 0 +/-0. 6 to 14. 5 +/-1. 3 ml O2. min-1 times 100 g-1).


Input: IGF I and insulin receptors are homologous proteins that function in distinct physiological pathways.

IGF I

insulin receptors


Input: Immunodepression was combined with the increase of glucocorticoid activity of adrenal cortex, while no significant changes in thyroid hormones were registered.


Input: Aberrant protein phosphorylation at tyrosine is responsible for the growth-inhibitory action of pp60v-src expressed in the yeast Saccharomyces cerevisiae.


Input: Acute pancreatitis: a multisystem disease.


Input: Alginate biosynthesis is controlled by a complex regulatory mechanism.


Input: The sequence upstream of the rhlA promoter contains two inverted repeats which define putative binding sites for the RhlR regulator.

rhlA promoter

RhlR regulator


Input: We have examined by in vitro footprinting a region located downstream of the human immunodeficiency virus, type 1 (HIV-1) promoter found to be hypersensitive to DNase I digestion in vivo.

DNase I


Input: The relative abundance of each alternatively spliced mRNA was determined by reverse transcription-polymerase chain reaction in various human tissues and cell lines.


Input: The retention index of 201Tl SPECT is a useful indicator of metastatic potential, thereby facilitating the prediction of prognosis, and provides insight into the relationship between 201Tl uptake and malignancy.


Input: The central globular domain is highly similar to those regions from other H1 molecules, and the carboxyl-terminal domain contains a repeating hexapeptide motif, variants of which are conserved among H1 molecules.

H1 molecules

H1 molecules


Input: The location and approximate length of the intron are conserved in both the tomato and Arabidopsis genes, with the intron separating the' nose' region (encoded by exon 1) from the central globular domain (exon 2).


Input: The topology and chain folding of the beta subunits in the artifactual beta 60 capsid are similar to the native alpha 3 beta 60 enzyme.

native alpha 3 beta 60 enzyme


Input: A constitutive mutant form with a single substitution (V88A) in the amino-terminal (response regulator) region was used.


Input: Comparisons of the four operon control regions studied indicate that the NarL heptamers are arranged with diverse orientations and spacing.

NarL heptamers


Input: Direct binding and competition assays using 30-mer oligonucleotide probes representing the individual CBF1 binding sites indicated that CBF1 bound less efficiently to the CD23 promoter and the EBV LMP-1 promoter sites than to the Cp site.

CBF1 binding sites

CD23 promoter

EBV LMP-1 promoter sites

Cp site


Input: We have found a satisfactory reproducibility in vitro (T1: 1. 9%; T2: 6. 2%), while the reproducibility was less satisfactory in vivo (T1: 16. 4%; T2: 13. 4%).


Input: CONCLUSION: Sonographic angiography has a possible role in the detection of small nodules in patients with CRF.


Input: Each expressed domain, as well as FKBP-33 itself, possesses peptidyl-prolyl cis-trans isomerase activity, though with much lower specific activities than FKBP-12.

peptidyl-prolyl cis-trans isomerase


Input: The first 85 nt upstream of the transcription initiation site of the mouse desmin gene, which contain an E box (E1), the binding site of the helix-loop-helix myogenic regulators, are sufficient to confer low level muscle-specific expression.

mouse desmin gene

helix-loop-helix myogenic regulators


Input: The acfD gene encompasses 254 nt that are predicted to encode an 88-amino-acid (aa) protein.

acfD gene


Input: We find that beta II PKC phosphorylates nuclear envelope lamin B at 10-20 times the rate of alpha PKC, whereas both kinases phosphorylate soluble lamin B at similar rates.

beta II PKC

nuclear envelope lamin B

alpha PKC

soluble lamin B


Input: Regulation of parathyroid hormone-related protein (PTHrP) gene expression.

parathyroid hormone-related protein

PTHrP


Input: We conclude that c-Abl activates c-myc transcription indirectly with no requirement for DNA binding by c-Abl.

c-Abl

c-myc

c-Abl


Input: Long-latency: locked units responded to shocks with little jitter and long latency (4-11 ms).


Input: The highly conserved ninth heptad, which is involved in heterodimerization, appears to participate in the receptor-inhibitor interaction, suggesting that the inhibitor is a related member of the receptor gene family.


Input: Here we show that for expression of snRNA genes in maize, a monocotyledonous plant, the USE and TATA elements are essential, but not sufficient, for transcription.


Input: Extensive DNA rearrangement occurs during the development of the somatic macronucleus from the germ line micronucleus in ciliated protozoans.


Input: An in vitro binding site selection procedure was used to determine DNA sequences preferentially bound by wild-type HLF and chimeric E2A-HLF proteins isolated from various t (17; 19)-bearing leukemias.

wild-type HLF

HLF


Input: The Oct-2 glutamine-rich and proline-rich activation domains can synergize with each other or duplicates of themselves to activate transcription.


Input: Taken together, our data suggest that Dbf8p plays an essential role in chromosome segregation.


Input: Ariga, Biochem.


Input: The diagnostic significance of creatine phosphokinase antibodies in the cardiac muscle in non-coronarogenic myocardial diseases

creatine phosphokinase


Input: According to the results of assays obtained with the use of assay systems ORTHO ELISA and ABBOTT HCV EIA (USA), the detection rate of anti-HCV-C100-3 among primary blood donors in Moscow was 1. 37% and was not different from that among HBsAg carriers (1. 8%) and among donors with anti-HCV-C100-3 in the blood (1. 6%) (p < 0. 01).

HBsAg


Input: We examined the hypothesis that the coronary vasomotor responses to etomidate (ETO), propofol (PRO), and sodium thiopental (STP) are mediated through contrasting effects on the resting nitric oxide (NO)-dependent vasodilator tone that opposes adrenergic vasoconstrictor activity in the intact dog.


Input: These alternative splice variants were detected in RNA isolated from several sources, including primary leptomeningeal tissue and an established line of leptomeningeal cells (LMC).


Input: Roux-en-Y gastroenterostomy severely disturbs emptying of the gallbladder.


Input: Surface-coil experiments on phantoms and on human calf muscles in vivo are presented.


Input: Large interpatient variation in peak PCZ plasma levels (91-3215 ng/ml) was seen, with the plasma half-life (t1/2 alpha) being approximately 57 min in patients given 135-180 mg/m2 PCZ.


Input: The maximal effect was seen at 100 ng/ml EGF, with a time lag of about 5 h.

EGF


Input: KAR1 encodes an essential component of the yeast spindle pole body (SPB) that is required for karyogamy and SPB duplication.


Input: CDC31 is required for SPB duplication and encodes a calmodulin-like protein that is most closely related to caltractin/centrin, a protein associated with the Chlamydomonas basal body.

calmodulin-like protein

caltractin

centrin


Input: During transcript elongation, the sizes of the DNA footprint and the single-stranded transcription bubble vary markedly among transcription complexes halted at different template positions.


Input: All our patients had polyps, 23 (54%) had asthma, 12 (27%) had aspirin sensitivity, 20 (65%) had eosinophilia, and 9 (69%) had increased total IgE levels.

IgE


Input: A new generation of information retrieval tools for biologists: the example of the ExPASy WWW server.


Input: The partial ORF was found to be identical to the C terminus of HrpJ2.


Input: The partial ORF was found to be identical to the C terminus of HrpJ2.


Input: Rapid detection of this mutation is achieved by restriction digestion of PCR-amplified genomic DNA; a mismatch primer combined with the point mutation creates a Tru9I restriction site.

Tru9I restriction site


Input: Wild type and mutant Epo cDNAs were transiently expressed at high levels in COS1 and COS7 cells.

Wild type and mutant Epo cDNAs


Input: OBJECTIVE--To assess the risk of hepatitis A in international travelers and to recommend preventive measures.


Input: The bactericidal effect of disinfectants against biofilm cells was found to be considerably enhanced by increasing the concentrations of the disinfectants.


Input: Expression of ME31B cDNA in S. pombe suppresses the ste13 mutation.

ME31B cDNA


Input: Use of Medi-Jector EZ dermojet for anesthesia in minor surgery


Input: The immune response of past-infection of cytomegalovirus in the patients of RTID is rather remarkable.


Input: Acupuncture effect on deep receptors was not limited to one point but within a certain area, namely distant effect existed.


Input: Reduced NK activity correlates with active disease in HIV-patients with multidrug-resistant pulmonary tuberculosis.


Input: Smoking history and awake oxygen saturation (SaO2) was recorded in all of them.


Input: (LH P < 0. 05, LH/FSH P < 0. 01).

LH

LH

FSH


Input: The relative R-and L-brain weights were found to be inversely related to the relative R-L brain weight only in the RH female cats with R-L brain weight smaller than zero (testosterone in males, estrogen in females).


Input: This mode of ternary complex formation is in contrast to the one seen in the promoter of the c-fos protooncogene, where formation of the ternary complex is dependent on the prior assembly of the serum response factor-DNA binary complex.

c-fos protooncogene

serum response factor-DNA binary complex


Input: Vaccinia virus-expressed, purified full-length HPV-16 and BPV-1 E2 proteins bound a consensus E2 site with high specific affinities (Kd = approximately 10 (-9) M) and stimulated in vitro transcription up to six-to eightfold.

full-length HPV-16 and BPV-1 E2 proteins

E2 site


Input: This alternatively spliced transcript contained an open reading frame extending from the upstream J alpha 11-2 region to 82 nucleotides downstream of the beginning of the TCR C alpha region, and potentially encoded a 36 amino acid polypeptide.

TCR C alpha region


Input: In HeLa x fibroblast cell hybrids its expression correlates with tumorigenicity.


Input: Demographic characteristics and risk factor data for 76, 672 clients were studied to characterize the distribution of infection with human immunodeficiency virus (HIV) and the use of counseling and testing facilities in Houston, Tex.


Input: Results indicate that KNM-LU 335 differs from both human and chimpanzee M1s in relative distances (measured in three dimensions) between crown fissure termini.


Input: We describe 49 cases with papillary tumor < 1 cm.


Input: Comparison with the bovine gene showed that the 5'-flanking region of the hATP1 gene has an unconserved guanine-cytosine (GC) rich region, including several binding motifs of transcriptional factors, such as Sp1, AP-2, and GCF.

hATP1 gene

GCF


Input: Structure, promoter analysis and chromosomal assignment of the human APEX gene.

human APEX gene


Input: The polyubiquitin gene was transcribed throughout the Volvox life cycle with peaks in the 1. 6-kb mRNA levels during pre-cleavage, cleavage, and post-inversion.

polyubiquitin gene


Input: Thus, in stress-induced arrhythmic disease as well as in ischemic heart disease, the main pathogenetic links are outside the heart, but they differ from those observed in ischemia.


Input: Here, we present genetic evidence in Saccharomyces cerevisiae for a functional interaction between the DEAH protein Prp16, and the U6 and U2 spliceosomal snRNAs.

DEAH protein Prp16

U2 spliceosomal snRNAs


Input: The consensus gene order deduced by combining data from both crosses is D2Mit1-(Dbh, Notch1)-(Col5a1, Rxra)-Spna2-Ab l-(Ak1, Fpgs)-(Grp78, Pbx3)-(Epb7. 2, Hc, Gsn)-Acra.

Dbh

Rxra

Ab l

Fpgs

Epb7. 2, Hc, Gsn

Acra


Input: The high level of transformation-associated deletions in the human YACs was reduced over 10-fold when the host was a recombination-deficient strain deleted for the RAD52 gene.

RAD52 gene


Input: In addition, the megabase region surrounding the dagA locus was mapped.

dagA locus


Input: These mutants had deletions of the extreme amino-terminal residues as far as amino acid residue 30.


Input: SECONDARY OUTCOME MEASURE--Double-blind caffeine-withdrawal evaluation.


Input: Elimination of natural antibodies in discordant xenografts


Input: An 8-bp sequence (ATTTCAAA) within the protected region shares significant homology with promoter sequences required for ethylene responsiveness from the tomato fruit-ripening E4 gene.

E4 gene


Input: We present evidence that DNA polymerase delta of Saccharomyces cerevisiae, an enzyme that is essential for viability and chromosomal replication, is also required for base excision repair of exogenous DNA methylation damage.

DNA polymerase delta of Saccharomyces cerevisiae


Input: We have identified two Marek' s Disease Virus (MDV) genes within the EcoRI-B fragment of MDV-GA genomic DNA.

EcoRI-B fragment


Input: Cowpox virus contains two copies of an early gene encoding a soluble secreted form of the type II TNF receptor.

early gene

type II TNF receptor


Input: Mutagenesis of each NRF-1 motif in the ALAS promoter gave substantially lowered levels of chloramphenicol acetyltransferase expression, whereas mutagenesis of both NRF-1 motifs resulted in the almost complete loss of expression.

NRF-1 motif

ALAS promoter

chloramphenicol acetyltransferase

NRF-1 motifs


Input: DNase I footprinting analysis indicated that DREF binds to the 24-bp DRE region of the DNA polymerase alpha gene in which 8-bp palindromic sequences are centered.

DNase I

DREF

DNA polymerase alpha gene


Input: Novel 8-base pair sequence (Drosophila DNA replication-related element) and specific binding factor involved in the expression of Drosophila genes for DNA polymerase alpha and proliferating cell nuclear antigen.

DNA polymerase alpha

proliferating cell nuclear antigen


Input: Most, however, would tell the spouse the full truth about both diagnosis and prognosis.


Input: Metabolism of calcium and vitamin D3 in patients with acute tubulointerstitial nephritis: a study of 41 patients with nephropathia epidemica.


Input: Furthermore, this study demonstrates that reduced inotropy with timolol helped uniform local contraction as estimated by the increased LONG/CIRC ratio, a transition that could improve contraction efficacy.


Input: Effects of moderate hypercapnia on hypothermia induced by cold He-O2 in rats.


Input: We recommend that ovarian stimulation is done only if there is a valid indication after proper assessment of the ovaries, and that women who have had ovarian stimulation are followed for longer than at present.


Input: A23187 did not induce any modifications of the endolymphatic potential, the ampullar direct current or the frequency of the evoked afferent spikes.


Input: Activation of the aboral ectoderm-specific Spec2a gene in blastula-stage sea urchin embryos requires an upstream regulatory region that is part of a repetitive sequence element (RSR) associated with all Spec1/Spec2 genes.

ectoderm-specific Spec2a gene


Input: A transcript of about 2 kb is expected for each PPO.

PPO


Input: Mutations in a region located 15 to 30 bp downstream from the major transcription start site that shows good homology to a sequence in the first exon of c-fos implicated as a negative regulatory element resulted in a significant increase in basal gene expression but did not affect regulation.

c-fos


Input: Salazopyrine desensitization


Input: During exercise, the Pes-Ves relation was shifted toward the left and the slope [end-systolic elastance (Ees)] increased from 7. 7 +/-2. 8 to 12. 7 +/-4. 2 (SD) mmHg/ml (P < 0. 05).


Input: We show that HRI and dsRNA-PK phosphorylate yeast eIF-2 alpha in vitro and in vivo and functionally substitute for GCN2 protein to stimulate GCN4 translation in yeast.

HRI

dsRNA-PK

yeast eIF-2 alpha

GCN2 protein


Input: Double-staining confirmed that there were separate populations of CD68-positive macrophages and XIIIa-positive dendrocytes.

XIIIa


Input: Interestingly, in the adult, transgene expression patterns within the cerebellum in two lines appeared to mark distinct anterior-posterior compartments.


Input: The concentrations of plasma ACTH and cortisol increased by 40% and 60% after MPTP treatment, respectively.

ACTH


Input: Instead, the results support the idea that Pc group products provide stable memory or imprinting of boundaries which are initially specified by gap and pair-rule regulators.

Pc group products


Input: To investigate the regulation of expression of the human mdr1 gene, the response of the mdr1 promoter to signals involved in cell proliferation was examined.

human mdr1 gene

mdr1 promoter


Input: Tobacco mosaic virus-infected tobacco (Nicotiana tabacum var.


Input: Through a stretch of 56 amino acids, constituting the MADS domain, the two proteins are identical except for two conservative amino acid substitutions.

MADS domain


Input: Isolation and characterization of SRF accessory proteins.

SRF accessory proteins


Input: These data suggest that: (a) proSRIF cleavage is initiated in the TGN, and (b) this reaction requires an acidic pH which is facilitated by a Golgi-associated vacuolar-type ATPase.

proSRIF

Golgi-associated vacuolar-type ATPase


Input: Clinical aspects of early increase in serum gamma-glutamyl transferase in cerebral infarction.

gamma-glutamyl transferase


Input: In the 3' flanking region of the 27 kDa zein gene, several AATAAA-like sequences and a sequence resembling the mammalian GT-rich sequence are present around the polyadenylation sites.

27 kDa zein gene


Input: The indoor radon concentration in the summer (1990) period ranged between 8 and 81 Bq m-3, while in the winter (1989-1990) it ranged between 20 and 143 Bq m-3 for the first year of measurements or between 8 and 92 Bq m-3 in the summer (1991) period and between 12 and 119 Bq m-3 in the winter (1990-1991) for the second year of measurements.


Input: DtxR is an iron-dependent sequence-specific DNA-binding protein that binds to the tox operator, an inverted-repeat nucleotide sequence located upstream from the diphtheria toxin gene.

DtxR

tox operator

diphtheria toxin gene


Input: Vasopressin (AVP), the antidiuretic hormone, is a cyclic nonapeptide that acts through binding to G protein-coupled specific membrane receptors pharmacologically divided into three subtypes (V1a, V1b, and V2) linked to distinct second messengers.

Vasopressin

AVP

G protein-coupled specific membrane receptors


Input: These results confirmed that cleavage of the leader peptide is the last step in nisin maturation and is necessary to generate a biologically active peptide.

nisin


Input: When the promoter region was linked with a heterologous reporter gene, we found that the promoter region is inducible by both interferons (interferon-alpha and-gamma) and interferon regulatory factor 1.

interferons

interferon-alpha and-gamma

interferon regulatory factor 1


Input: Anti-B. burgdorferi, anti-B. turicatae and anti-B. parkeri antibodies, tested by the indirect immunofluorescent assay (IFA), were detected in 10. 8, 16. 1 and 8. 2% of the serum samples tested, and confirmed by IFA-ABS in 1. 3, 1. 3 and 1. 0%, respectively.

Anti-B. burgdorferi

anti-B. turicatae

anti-B. parkeri antibodies


Input: The approach derives from a recently described strategy for making recombinants from five overlapping EBV cosmid-cloned DNAs (B.


Input: Evaluation of desmopressin for dental extractions in patients with hemostatic disorders.


Input: Comparative analysis with an antiandrogen niftolid and synthetic GnRH was carried out in 22 normal subjects, 14 patients with primary and 20 ones with secondary hypogonadism, and in 5 patients with clinical signs of gonadal insufficiency and obscure diagnosis in order to elucidate the pituitary gonadotropin reserves.

synthetic GnRH

pituitary gonadotropin


Input: The cis-acting regulatory properties of an 872 bp promoter fragment of a B. napus oleosin gene were examined by analysis of beta-glucuronidase (GUS) expression in transgenic tobacco plants containing an oleosin promoter-GUS transcriptional fusion.

oleosin gene

beta-glucuronidase

GUS

oleosin promoter

GUS


Input: This indicates that the mechanism by which CX blocks rapid degradation of tubulin mRNA in vivo is not simply by preventing its translation and suggests the involvement of an altered trans-factor.

tubulin mRNA


Input: Increasing the extracellular calcium concentration enhanced detrusor contractility in a dose-dependent manner in both control and obstructed bladders.


Input: Structural organization of the gene encoding the human lipocalin tear prealbumin and synthesis of the recombinant protein in Escherichia coli.

human lipocalin tear prealbumin


Input: The sequence has a 1092-bp open reading frame encoding a protein of 364 amino acids.


Input: The gene organization of CRSV RNA-1 is similar to those of red clover necrotic mosaic (RCNMV) and sweet clover necrotic mosaic (SCNMV) dianthoviruses with the exception that CRSV RNA-1 contains the additional 3'-terminal ORF.

CRSV RNA-1

CRSV RNA-1


Input: We have previously shown that LBP-1 represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA box.

TFIID


Input: These results illustrate an important role for La in RNA production by demonstrating its ability to clear the termination sites of class III templates, thereby promoting efficient use of transcription complexes by pol III.

La

pol III


Input: The films were analyzed using a scanning helium-neon laser densitometer with a small aperture of 5-10 microns.


Input: The GafChromic method has proven to be an accurate and rapid method of analysis and could be easily incorporated into a quality assurance program.


Input: Viral genomic RNA for these reactions was obtained directly from fecal specimens of infected infant rats.


Input: GATA-1 mRNA was present in equivalent levels in both erythroid cell lines, but at a low level in FDC-P1 cells.

GATA-1 mRNA


Input: Tumor necrosis factor-alpha (TNF alpha) is one of several autocrine/paracrine factors known to exert potent inhibitory effects on bone.

Tumor necrosis factor-alpha

TNF alpha


Input: We have investigated the role of cellular p21ras protein in insulin and insulin-like growth factor-I (IGF-I) signaling pathways.

cellular p21ras protein

insulin

insulin-like growth factor-I

IGF-I


Input: The lack of the C2 domain of the Ca (2 +)-dependent PKCs and the presence of a unique NH2-terminal sequence with a potential signal peptide and a transmembrane domain suggest that PKC mu is a novel member of the subgroup of atypical PKCs.

Ca (2 +)-dependent PKCs

PKC mu

PKCs


Input: Moreover, we observed that the function of T3R-RXR heterodimers on response elements composed of two half-sites in a directly repeated orientation spaced by 4 nucleotides is determined in major parts by the 5'-flanking sequence of the upstream half-site.

RXR


Input: However, three Hm1 mutants that were moderately deficient in stimulating PI turnover displayed normal sequestration, suggesting distinct mechanisms.

Hm1 mutants


Input: Furthermore, in vitro decay reaction mixtures supplemented with the 20-nt sense RNA transcript resulted in stabilization of R2 message.

R2 message


Input: Deletion analyses of the pCD41 ORF-A and the use of promoter constructs further mapped an internal functional promoter within the pCD41 sequence that can direct the synthesis of the trans-activating protein.

pCD41 ORF-A

pCD41 sequence


Input: The inferred amino acid sequence of the cyanobacterial HemB protein indicates a significant difference in the metal cofactor requirement from the higher-plant enzymes, which was confirmed by overexpression and biochemical analysis.

cyanobacterial HemB protein


Input: METHODS AND RESULTS: In 25 open-chest, anesthetized dogs, progressive circumflex artery stenosis led to a concordant decrease of circumflex artery resting and hyperemic flow, coronary flow reserve, and inverse angiographic mean transit time Tmicro-1 (P <. 01).


Input: However, a correlation was observed between SF levels of IL-8 with those of lactate, LDH, beta 2-microglobulin and glucose.

LDH

beta 2-microglobulin


Input: Sodium-taurocholate-induced acute necrotizing pancreatitis does not affect jejunal oxygenation in pigs.


Input: Although inactive in cells under normal conditions, the CHOP gene is markedly induced by a variety of cellular stresses, including nutrient deprivation and metabolic perturbations.

CHOP gene


Input: The ipiO genes code for two almost identical 152-aa proteins which do not have any homology with sequences present in data libraries.

ipiO genes


Input: Sterol analysis of the disrupted mutant demonstrated the accumulation of ignosterol, indicating a loss of Erg24p activity.


Input: In these experiments we begin to study the potential functions of the alpha 7 cytoplasmic domain by analyzing homologies between the rat and human sequences, by immunologic studies using an anti-cytoplasmic domain antiserum, and by identifying two alternate forms.

alpha 7 cytoplasmic domain


Input: The alpha 7A form RNA contains an additional 113 nucleotides compared to the B form, and a common coding region in the A and B form RNAs is used in alternate reading frames.


Input: In order to evaluate the function of the hypothalamic-pituitary-thyroid (HPT)-axis in unipolar depression, the authors measured basal 0800h plasma levels of free thyroxine (FT4), free triiodothyronine (FT3), and thyroid stimulating hormone (TSH) by means of the new, ultrasensitive assays (TSH-IRMA) in 69 healthy controls, 62 minor, 101 simple major, and 57 melancholic depressed subjects.

thyroid stimulating hormone

TSH


Input: CRS function in a 5' LTR-linked gene expression assay correlates with the ability of both p60CRS and p40CRS to interact with 5' LTR RNA in vitro.

CRS


Input: Serial levels of troponin T and the activity of CK-MB were measured 6, 12, 24 and 48 h after aortic unclamping.

troponin T

CK-MB


Input: Regionalization of drug delivery is a potential method to avoid this problem.


Input: The epidemic occurred in a group of 26 community members (23 men and 3 women, mean age, 28. 9--3 years) living and working together, who underwent acute and convalescent serologic tests for Mycoplasma pneumoniae, Legionella pneumophila, cytomegalovirus, adenovirus, Coxiella burnetii, and Chlamydia pneumoniae.


Input: MEK itself is activated via serine phosphorylation by upstream activator kinases, including c-raf, mos and MEK kinase.

MEK

upstream activator kinases

c-raf

mos

MEK kinase


Input: Members of SVA are also present in the complement C2 gene located about 20 kilobases upstream of RP1 in the HLA and in the cytochrome CYP1A1 gene.

SVA

complement C2 gene

HLA

cytochrome CYP1A1 gene


Input: European Community Huntington' s Disease Collaborative Study Group.


Input: The c-myc and skeletal alpha-actin gene promoters contain YY1 binding sites thought to act either as positive or negative cis-acting elements.

c-myc

skeletal alpha-actin gene promoters

YY1 binding sites


Input: MSSP-1 produced in E. coli as a fusion protein with GST specifically interacted with single-stranded TCTTAT (plus myc (H-P) 21) and ACT-ATT (in minus myc (H-P) 21), the consensus of which can be referred to as A/TCTA/TA/TT.

GST

myc

myc


Input: Within 12 hours after MR tomography the patients were surgically explored, biopsied and if necessary orchiectomised.


Input: Varieties of envious experience.


Input: The results show that both the amino and carboxy termini of the NS1 protein molecule and the cysteines at residues 337 and 340 are essential for tubule formation.

NS1 protein molecule


Input: The 3' UTR has several stable hairpins that are flanked by single-stranded (A/U) UGC sequences.


Input: Moreover, the major site of transcriptional initiation, which was localized by primer extension 250 bp upstream of the 5' end of the Ets-1 cDNA clone, was shown to be identical in normal cells and tumors carrying a provirus in the Tpl-1 locus.

Ets-1 cDNA clone

Tpl-1 locus


Input: Specifically, by oligonucleotide-directed site-specific mutagenesis, we demonstrate that of 10 cysteine residues in the ORF4 polypeptide, only C-421 and C-426 are essential for transactivator function and suggest that these cysteine residues may participate in critical protein-protein interactions rather than protein-nucleic acid interactions to mediate ORF4 inducibility.


Input: To search for genes that interact with the SLK1-SLT2 pathway, a synthetic lethal suppression screen was carried out.


Input: Genetic and phenotypic analysis indicates that NHP6A and NHP6B function downstream of SLT2.


Input: In this report, we present two lines of evidence that all ribosomes which synthesize GCN4 have previously translated uORF1, resumed scanning, and reinitiated at the GCN4 start site.


Input: Identical components of yeast transcription factor IIIB are required and sufficient for transcription of TATA box-containing and TATA-less genes.

transcription factor IIIB


Input: Concordantly, it was shown that the dnHLH protein Id1 inhibits differentiation of muscle and myeloid cells in vitro.

dnHLH protein Id1


Input: RNP1, a new ribonucleoprotein gene of the yeast Saccharomyces cerevisiae.


Input: Crohn' s disease in prolonged remission: should one augment protein-calorie intake as compared to healthy subjects?] The aim of our two year prospective study was to evaluate whether adult Crohn' s disease patients in prolonged remission (CDAI < 150), in order to maintain their body weight as close as possible to the ideal one, need a protein-calorie intake higher than the predicted one and that of healthy controls.


Input: To achieve complete dissection of the anterior vitreous, we remove even a clear lens during the first surgical intervention in selected cases.


Input: Restoration of opponens function with transplantation of free composites dorsal pedal skin flap containing m. extensor hallucis brevis


Input: Neither ethanol regimen impaired spontaneous alternation, but the 4 g ethanol. kg-1 x day-1 regimen increased the percent completed trials.


Input: The mean (+/-sd) intra-vesicular pressure (IVP) and maximal urethral closure pressures (MUCP) were 10. 3 (+/-1. 7) and 129. 8 (+/-19. 6) cmH2O, respectively, and the ratio between MUCP and IVP was 13. 2 (+/-2. 5).


Input: Several highly conserved regions were identified at the near N terminus, middle and C terminus.


Input: Thioredoxin (TR) is a small ubiquitous dithiol-reductase enzyme first identified in bacteria and plants.

Thioredoxin

TR

dithiol-reductase enzyme


Input: The mutation within the asgB480 allele was identified as an A-to-G transition that results in a threonine-to-alanine substitution in the predicted protein product.

asgB480 allele


Input: The cysteine-rich region of raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-ras.

raf-1 kinase

GTP-ras


Input: Kinetic coupling and requirement for ATP hydrolysis.


Input: ATP by itself also reduced polypeptide binding to Ssb1/2p to a level that was intermediate between that observed for the Ssa Hsp70 proteins tested and BiP and DnaK.

Ssa Hsp70 proteins

BiP

DnaK


Input: Digestion of NF-IL6 with endoprotease Asp-N produced a domain smaller than the TCD (NF-IL6 bZIP domains (NFBD) (272-345)), a domain identified either in the absence or the presence of DNA.

endoprotease Asp-N

TCD

NF-IL6 bZIP domains

NFBD


Input: Signaling by tyrosine kinases involves direct associations between proteins with Src homology 2 (SH2) domains and sites of tyrosine phosphorylation.

tyrosine kinases

Src homology 2


Input: Rather, complete skipping of exon V and subsequent joining of exon IV to exon VI caused a shift in the open reading frame, which remodeled GPHe (P2) with an elongated new hydrophobic sequence for membrane anchoring.

GPHe (P2)


Input: The responses of the " stress hormones " cortisol, 11-deoxycortisol, ACTH, vasopressin (AVP), and corticotropin releasing factor (CRF) were studied in 6 normal males in response to acute cortisol deficiency induced by the 11-beta-hydroxylase inhibitor, metyrapone.

ACTH

vasopressin

AVP

corticotropin releasing factor

CRF


Input: Thus our observations establish a functional link between the PKC and retinoid pathways, which are generally considered to have antagonistic activities on differentiation processes.

PKC


Input: The colony-stimulating factors (CSFs) principally involved in the production of neutrophils and monocytes are granulocyte CSF, granulocyte-macrophage CSF, macrophage CSF, and interleukin 3 (sometimes called multi-CSF).

colony-stimulating factors

CSFs

granulocyte CSF

granulocyte-macrophage CSF

macrophage CSF

interleukin 3

multi-CSF


Input: The degree of lung destruction, reflected by interstitial hemorrhage was assessed by measuring hemoglobin content in the fluid of the lavaged lungs.

hemoglobin


Input: Expression plasmids harboring full-length or kinase domain of PKC alpha and PKC delta (PKC alpha K and PKC delta K) were constructed.

PKC alpha

PKC delta

PKC alpha K

PKC delta K


Input: These results indicate that both PKC alpha (calcium dependent) and PKC delta (calcium independent) may mediate the transcription of TPA-inducible genes through both AP-1 and non-AP-1 sequences.

PKC alpha

PKC delta


Input: With a cutoff level for TSST-1 of less than 100 pg/ml, 28 samples obtained from 12 patients were positive for TSST-1.


Input: Panlobular emphysema


Input: Since the ETS domain, which is localized in the carboxy terminal region of the encoded protein, is 95% and 96% identical to that of PEA3 and ER81, respectively, we named this new member' Ets Related Molecule PEA3-like' (ERM).

ETS domain

' Ets Related Molecule PEA3-like'

ERM


Input: Gel shift analysis indicates that the full-length ERM protein is able to bind specifically to an oligonucleotide containing the consensus nucleotide core sequence GGAA recognized by the Ets proteins.

full-length ERM protein

Ets


Input: Effects of estradiol on worm burden and peripheral leukocytes in Parastrongylus malaysiensis-infected rats.


Input: Dotarizine produced arterial dilation in both systemic and pulmonary circulation: the total peripheral resistance dropped, and femoral artery flow rose; aortic and pulmonary artery mean and diastolic pressures declined, and systolic pressures remained almost stable.


Input: These issues include the use of LMWHs in patients with arterial thrombosis or myocardial infarction (e. g. in conjunction with thrombolytic treatment), and in patients with pulmonary embolism.


Input: The usefulness of the lambda PG15 and the lambda AD5 cloning vectors was demonstrated by constructing large Neurospora crassa cDNA libraries.


Input: Endoscopic transthoracic sympathectomy as adjuvant treatment for critical upper-limb ischaemia.


Input: Sequence comparisons have shown that Aps1p is more similar to the sigma subunit of the Golgi-localized mammalian AP-1 complex than Aps2p, which is more related to the plasma membrane AP-2 sigma subunit.

AP-1 complex

AP-2 sigma


Input: The Saccharomyces cerevisiae APS1 gene encodes a homolog of the small subunit of the mammalian clathrin AP-1 complex: evidence for functional interaction with clathrin at the Golgi complex.

Saccharomyces cerevisiae APS1 gene

mammalian clathrin AP-1 complex

clathrin


Input: These results are the first to demonstrate the structural organization of a vertebrate gene encoding an integral membrane protein of the nuclear envelope that may be a member of a family of polypeptides conserved in evolution.


Input: Biochemical characterization of valosin-containing protein, a protein tyrosine kinase substrate in hematopoietic cells.

valosin-containing protein

protein tyrosine kinase


Input: The presence of the foreign gene was confirmed by Southern analysis.


Input: All patients with deterioriation in mental status showed a marked increase in liver enzymes (aspartate and alanine aminotransaminases) and severe coagulopathy.

aspartate and alanine aminotransaminases


Input: Functional postnatal development of the rat primary visual cortex and the role of visual experience: dark rearing and monocular deprivation.


Input: Eleven patients tested positive for the hepatitis B surface antigen (HBsAg).

hepatitis B surface antigen

HBsAg


Input: The xylose isomerase-encoding gene (xylA) of Clostridium thermosaccharolyticum: cloning, sequencing and phylogeny of XylA enzymes.

xylose isomerase-encoding gene

xylA

XylA enzymes


Input: Two phosphopeptides, identified as RS-[32P] SGASGLLTSEHHSR and S-[32P] SGASGLLTSEHHSR, were obtained after stoichiometric phosphorylation and trypsinization of the peptide.


Input: Altogether, these data suggest that Ypt51p, Ypt52p, and Ypt53p are required for transport in the endocytic pathway and for correct sorting of vacuolar hydrolases suggesting a possible intersection of the endocytic with the vacuolar sorting pathway.

vacuolar hydrolases


Input: All of the basal TPN solutions were isonitrogenous and identical in nutrient composition, except for the difference in energy level, which was adjusted with glucose.


Input: Surprisingly, TFIIIC alpha has no homology to any of the yeast TFIIIC subunits already cloned, suggesting a significant degree of evolutionary divergence for RNA polymerase III factors.

TFIIIC alpha

yeast TFIIIC subunits

RNA polymerase III factors


Input: Transactivation domain is located downstream of the 128-amino-acid runt homology region, referred to as the Runt domain.

128-amino-acid runt homology region

Runt domain


Input: We estimate that the protease activity is at least 35-fold greater in mature B cells than in pre-B cells.


Input: The ligand for RXR, 9-cis retinoic acid, has the opposite effect of destabilizing the heterodimeric-DNA complex.

RXR


Input: Cerebral125 albumin was increased to similar proportions in those groups submitted to hyperosmolality.

Cerebral125 albumin


Input: Retrogradely labelled neurons significantly prevailed in the ipsilateral substantia nigra pars compacta.


Input: Therefore, the amino-terminal sequence of the purified carA product is identical to that derived from the nucleotide sequence in both organisms, P. stutzeri having four additional amino acids.

carA product


Input: Aneurysmal bone cyst of the jaws: analysis of 11 cases.


Input: Location and orientation of an activating region in the Escherichia coli transcription factor, FNR.

FNR


Input: Moxidectin (at 3 times the therapeutic dose) did not have deleterious effects on cow reproductive performance as examined (eg, at folliculogenesis, ovulation, and the early embryonic phase of development).


Input: Northern-blot analysis of mRNA from Avicel-grown N. patriciarum showed that xynB hybridized to a 3. 4 kb mRNA species.

xynB


Input: The variable regions of vertebrate striated TnT isoforms reflect the subsequent addition and modification of genomic sequences to give rise to members of the TnT multigene family.

TnT isoforms

TnT multigene family


Input: Simple reaction time (RT) to a peripheral visual target (S2) is shortened when a non-informative cue (S1) is flashed at the S2 location 100-150 ms before target onset (early facilitation).


Input: These viruses depend on the host cell machinery for their existence, and interference with these processes typically interferes with other important host physiology.


Input: Treatment was well-tolerated.


Input: A concentration of 12. 5 ppm SO2 induced a decrease from baseline values of approximately 80% in mean MCA and of roughly 70% in mean CBF.


Input: We have used these modified assay conditions to extend studies on the transposition pathway.


Input: Renal cell carcinoma in children: a single institution' s experience.


Input: The data suggest that ICP10 constitutively increases ras activity, and its TM segment plays a critical role in transformation-related signaling pathways.

ras


Input: Five concensus poly A addition sites are located in the 350 base pairs immediately following the protein IX coding region.

protein IX


Input: Factors associated with intrafamilial transmission of hepatitis B virus infection in Korea.


Input: Northern analysis, to search for a pcbAB transcript, showed no distinct transcript and indicated severely degraded mRNA.

pcbAB transcript


Input: The high degree of conservation between NQO2 and NQO1 gene organization and sequence confirmed that NQO2 gene encodes for a second member of the NQO gene family in human.

NQO1 gene

NQO2 gene

NQO gene family


Input: The efficacy of a Propionibacterium acnes product for treatment of coliform mastitis was evaluated following intramammary infusion of Escherichia coli.


Input: The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32.

human eps15 gene

tyrosine kinase


Input: The gene encoding the 105-kDa protein (p105) precursor of the p50 subunit of transcription factor NF-kappa B also encodes a p70 I kappa B protein, I kappa B gamma, which is identical to the C-terminal 607 amino acids of p105.

105-kDa protein (p105) precursor

p50 subunit

NF-kappa B

p70 I kappa B protein

I kappa B gamma


Input: Alternative splicing of RNA transcripts encoded by the murine p105 NF-kappa B gene generates I kappa B gamma isoforms with different inhibitory activities.

p105 NF-kappa B

I kappa B gamma isoforms


Input: The experiment included 6 male and 4 female healthy subjects who, during a 24-hour stay in the respiration chambers, performed, in the morning and afternoon, 15 min cycling with the total work of 6, 750 kg m.


Input: These rearrangements result in the formation of chimeric genes showing the tyrosine kinase domain of ret fused with the 5' end sequences of different genes.

tyrosine kinase domain

ret


Input: Frequent loss of heterozygosity (LOH) of > 30% of the informative cases was observed on chromosomes 3p (41. 1%), 5q (52. 6%), 6p (30. 4%), 8p (33. 3%), 9p (35. 7%), 9q (30. 8%), 11p (32. 4%), 13q (52. 7%), 17p (55. 2%), 17q (33. 3%), 18q (45. 7%), and 19q (30. 4%).


Input: A single amino acid change in the CPY vacuolar sorting signal prevents this interaction.

CPY vacuolar sorting signal


Input: Glutamyl-tRNA synthetase and prolyl-tRNA synthetase belong to different classes of aminoacyl-tRNA synthetases that are thought to have evolved along independent evolutionary pathways.

Glutamyl-tRNA synthetase

prolyl-tRNA synthetase

aminoacyl-tRNA synthetases


Input: Using the sequence data obtained from the human TCRAC/TCRDC region, we have extended a polymerase chain reaction-based assay to test for the expression of the individual TCRAJ gene segments.

TCRAC

TCRDC

TCRAJ gene segments


Input: This analysis revealed an intact gene (arg4) showing a high degree of homology with the Saccharomyces cerevisiae CPA2 gene encoding the large subunit of carbamoyl-phosphate synthetase (CPS-A).

Saccharomyces cerevisiae CPA2 gene

carbamoyl-phosphate synthetase

CPS-A


Input: The baroreflex latency (from the ECG R-wave to the integrated MSNA burst peak) was constant at approximately 1. 20 s during sleep, suggesting that pulse-synchronicity was maintained.


Input: DESIGN--A randomised study was conducted in all women aged 50-70 years who were eligible for breast cancer screening and living in the city of Utrecht.


Input: Identification of an immediate-early gene in the Marek' s disease virus long internal repeat region which encodes a unique 14-kilodalton polypeptide.

immediate-early gene


Input: We have used a full-length cDNA clone of a mouse hepatitis virus strain A59 defective interfering (DI) RNA, pMIDI-C, and cassette mutagenesis to study the mechanism of coronavirus subgenomic mRNA synthesis.

pMIDI-C


Input: To study the structure-function of the gene 5 product, wild-type and mutant forms of NS53 were produced by using a recombinant baculovirus expression system and a recombinant vaccinia virus/T7 (vTF7-3) expression system.

gene 5 product


Input: Gel electrophoresis and Western immunoblot analyses of intracellular fractions derived from infected cells revealed that large amounts of NS53 were present in the cytosol and in association with the cytoskeletal matrix.


Input: The transcription factor AP-2 is encoded by a gene located on chromosome 6 near the HLA locus.

transcription factor AP-2

HLA locus


Input: The mature AP-2 mRNA is spliced from 7 exons distributed over a region of 18 kb genomic DNA.

AP-2 mRNA


Input: San Martin' s psychological traits coupled to his work with masonic lodges that allowed him to display his abilities as strategist and political ruler.


Input: The participants were homosexual men in hepatitis B vaccine trials in Amsterdam (n = 74), New York City (n = 120), and San Francisco (n = 168).


Input: Comparison with the crystal structure of Desulfovibrio gigas, Dg, Fd (Kissinger et al., 1991) reveals a very similar folding topology, although several secondary structural elements are extended in Pf relative to Dg Fd.

Fd

Fd


Input: CONCLUSIONS: Serum prolactin concentrations show age related variations in presumably fertile men.

Serum prolactin


Input: Eight highly trained male kayakers were studied to determine the relationship between critical power (CP) and the onset of blood lactate accumulation (OBLA).


Input: As in S. cerevisiae, the sequence of rhp51 + showed two MluI cell-cycle boxes and a putative DNA damage-responsive element in its upstream region.

rhp51 +

MluI cell-cycle boxes


Input: A partial cDNA sequence indicated that the T lymphocyte early-activation gene (Tea) encodes a protein related to the dual-function ecotropic retrovirus receptor/cationic amino acid transporter (ecoR/CAT1), and RNA blots suggested highest Tea expression in T lymphocytes and liver (MacLeod, C. L., Finley, K., Kakuda, D.

T lymphocyte early-activation gene

Tea

ecotropic retrovirus receptor

cationic amino acid transporter

ecoR

Tea


Input: Furthermore, unlike the case for HIS3 where only a limited subset of TATA-like sequences can activate transcription in conjunction with GCN4p, many divergent TATA-like sequences allowed GCN4p activation of TRP3.


Input: Bacterially expressed protein, as well as the in vitro reticulocyte lysate translation product, comigrated with the purified 37-kDa protein on sodium dodecyl sulfate-polyacrylamide gels.


Input: In addition, this kinase is well conserved evolutionarily, ubiquitously expressed, and its genes map to a position on human chromosome 1 frequently deleted in the late stages of tumorigenesis.


Input: Deletion analysis of the ICL1 promoter led to the identification of an upstream activating sequence element, UASICL1 (5' CATTCATCCG 3'), necessary and sufficient for conferring carbon source-dependent regulation on a heterologous reporter gene.

ICL1 promoter


Input: In Mv1Lu lung epithelial cells, ActR-IB and T beta R-I signal a common set of growth-inhibitory and transcriptional responses in association with their corresponding ligands and type II receptors.

ActR-IB

T beta R-I

type II receptors


Input: H-7, which specifically, although weakly, inhibited PKC activation, had no effect on tyrosine phosphorylation and PtdIns (3, 4) P2 production.

PKC


Input: The effects of systemic glucose concentration on brain metabolism following repeated brain ischemia.


Input: A-69-year-old patient with postoperative small-bowel obstruction underwent laparotomy three times.


Input: On physical examination a mild symmetrical polyarthritis of small and large joints was seen.


Input: We conclude that the SIMV is useful in weaning neonates from the ventilator.


Input: VP-16, ifosfamide and cisplatin (VIP) for extensive small cell lung cancer.


Input: A total of 7 (4 males and 3 females) patients were included in this retrospective study to determine the sensitivity of radioimmunoscintigraphy with I-131 labeled anti CEA/CA 19-9 monoclonal antibodies.

anti CEA

CA 19-9


Input: A genomic clone for the cyc07 gene, which is expressed specifically at the S phase during the cell cycle in synchronous cultures of periwinkle (Catharanthus roseus) cells, was isolated.

cyc07 gene


Input: CONCLUSIONS: Translocation of bacteria or endotoxin from the gastrointestinal tract into the bloodstream has been noted in animal experiments; however, translocation was not detected in our patients with hemorrhagic shock.


Input: Southern blotting analysis implied the occurrence of multiple COXVb genes in the rat genome.

COXVb genes


Input: Acylation with the palmitate analog was prevented when Gly-2 was mutated to alanine, implying that N-myristylation is required for palmitylation, and when either Cys-3 or Cys-6 was mutated to serine.


Input: Subunit composition and domain structure of the Spo0A sporulation transcription factor of Bacillus subtilis.

Spo0A sporulation transcription factor of Bacillus subtilis


Input: Electrophoretic mobility shift analysis indicates that NF-IL-6, as well as other related members of this family, bind specifically to the NF-IL-6 site in the IL-8 promoter.

IL-8 promoter


Input: BYV, citrus tristeza virus (CTV), beet yellow stunt virus (BYSV) and carnation necrotic fleck virus templates produced 1 kb amplification products, which were shown by sequencing to represent fragments of the respective HSP70 genes.

HSP70 genes


Input: The p53 tumor suppressor gene product, a sequence-specific DNA-binding protein, has been shown to act as a transcriptional activator and repressor both in vitro and in vivo.

p53 tumor suppressor gene product


Input: Mutational analysis of chromosomal segment 64AB, a region containing the glutamic acid decarboxylase gene.

glutamic acid decarboxylase gene


Input: Rearrangements of the NFKB2 gene are associated with lymphoid malignancies, but the functional significance of these alterations is not known.

NFKB2 gene


Input: Cloning and sequencing of the corresponding cDNAs indicates that, via alternative splicing, the rearranged gene codes for two proteins of 84 and 85 kD (p84/85) which retain the DNA-binding rel domain and the first five ankyrin repeats, but have lost their carboxy-terminus including the seventh ankyrin repeat.

rel domain

ankyrin

ankyrin


Input: Transient co-transfection assays involving NFKB2 expression vectors and kappa B-driven reporter plasmids indicate that NFKB2 p85 has lost the transcriptional repressor functions typical of normal NFKB2 p52.

kappa B

NFKB2 p85

NFKB2 p52


Input: Also, HR21ap as well as HR21Xap are specific in their inhibition of Sp1 binding.


Input: Intravenous antibiotic therapy in cystic fibrosis: in hospital or at home?


Input: Open reading frames in a 4556 nucleotide sequence within MDV-1 BamHI-D DNA fragment: evidence for splicing of mRNA from a new viral glycoprotein gene.

MDV-1 BamHI-D DNA fragment


Input: The ns2 gene comprises an open reading frame (ORF) encoding a putative nonstructural (ns) protein of 279 amino acids with a predicted molecular mass of 32-kDa.

ns2 gene


Input: The hydrophobicity profile of the methyltransferase reveals the presence of at least five potential transmembrane domains.


Input: Measurement of SaO2 at moderate altitude can be helpful in the care of both healthy and ill newborns or infants.


Input: To determine whether the excess prevalence of human immunodeficiency virus type 1 (HIV-1) infection in US black and Hispanic homosexual men relative to white men can be explained by differences in sociodemographic factors, history of sexually transmitted diseases, or sexual and drug-use behaviors, the authors conducted a cross-sectional analysis of baseline HIV-1 seroprevalence and HIV-1 risk factors among 4, 475 non-Hispanic white, 234 Hispanic white, and 194 black homosexual men from four centers in the United States (Baltimore/Washington, DC, Pittsburgh, Chicago, and Los Angeles).


Input: The patients in one group had intrauterine catheters inserted and oxytocin was titrated to achieve the 75th percentile of uterine activity observed in spontaneous normal labour according to parity.

oxytocin


Input: Continued development of the rat conditioning paradigm is especially warranted because of the ability to record sympathetic nerve activity in intact, awake subjects and the large number of readily available genetic strains, which model human pathological states.


Input: The ultrastructure of retinal vessels was examined in three eyes from diabetic patients and two eyes from control subjects.


Input: The regulatory region also has a sequence similar to the binding site for a liver-specific transcription factor, hepatocyte nuclear factor 1 (HNF-1), at positions-120 to-132.

hepatocyte nuclear factor 1


Input: Thus, we have identified a GRE sufficient to account for full glucocorticoid inducibility and an HNF-1 site close to the promoter that are major determinants of transcriptional control of the Xenopus fibrinogen B beta subunit gene in cells from normal liver tissue.

HNF-1 site

Xenopus fibrinogen B beta subunit gene


Input: Acad.


Input: The PRB-1b gene encodes for a basic-type component of the pathogenesis-related PR-1 protein family.

PRB-1b gene

PR-1 protein family


Input: Replacement of the CRE with a second copy of the AP-1 site results in a level of transcriptional activity comparable with that of the wild-type sequence, but replacement of the AP-1 site with a CRE abolishes activity.

AP-1 site

AP-1 site


Input: The T-cyt promoter, although of bacterial origin is active in planta and the 30 bp cyt-1 element is located within a region that is essential for T-cyt promotor activity in leaf, stem and root cells of tobacco plants.

T-cyt promoter

30 bp cyt-1 element

T-cyt promotor


Input: Reviewing manuscripts: developing an efficient system.


Input: We suggest that CT scan be preferable in diagnosis of tumors in that area.


Input: Effect of aging on respiratory skeletal muscles.


Input: Two BASIC computer programs using logit transformation for the analysis of S-shaped curves are presented.


Input: The yeast SSS1 gene is essential for secretory protein translocation and encodes a conserved protein of the endoplasmic reticulum.

yeast SSS1 gene


Input: The lengths of the complete polypeptide chain of the recombinant enzyme and its transit peptide are 388 and 53 residues, respectively.


Input: The absence of H4PteGlun bound to the T protein in our experimental conditions demonstrates that H4PteGlun is not covalently linked to the T protein.

T protein

T protein


Input: TATA and CCAAT boxes are located 34-bp and 68-bp, respectively, upstream of the transcription start site, the 5'-untranslated leader is 78 nucleotides long, and the intronless gene has at least two different polyadenylation sites.


Input: GGS1 is the same gene as TPS1 which was identified as encoding a subunit of the trehalose-6-phosphate synthase/phosphatase complex and it is allelic to the fdp1, byp1, glc6 and cif1 mutations.

trehalose-6-phosphate synthase/phosphatase complex


Input: We also compared the sequence with the partly homologous products of the S. cerevisiae genes TPS2 and TSL1 which code for the larger subunits of the trehalose synthase complex and with a TSL1 homologue, TPS3, of unknown function.

trehalose synthase complex

TSL1 homologue


Input: Stroop interference: aging effects assessed with the Stroop Color-Word Test.


Input: CONCLUSION: The study demonstrates that transvaginal ultrasonography has an efficiency of 88% in differentiating endometriomas from other ovarian masses with a specificity of 90%.


Input: Genomic Southern blot analysis of rat EFIA (gene encoding enhancer factor I subunit A) reveals a complex band pattern when cDNA subfragment probes are used.

rat EFIA

enhancer factor I subunit A


Input: The effect of ibopamine and furosemide in 130 patients with NYHA Class I and II heart failure were studied in a parallel, double-blind, randomized placebo-controlled multi-centre trial.


Input: The nit-3 gene of the filamentous fungus Neurospora crassa encodes nitrate reductase, the enzyme which catalyzes the first step in nitrate assimilation.

nit-3 gene of the filamentous fungus Neurospora crassa

nitrate reductase


Input: Unfolding can be described by a two-state process since a ratio of delta Hcalorimetric to delta Hvan' t Hoff equals 0. 96.


Input: This motif has been shown to mediate protein interactions in the case of ankyrin as well as several other repeat-bearing proteins.

ankyrin


Input: [Ala85] Dk (69-85) retains full biological activity.

[Ala85] Dk (69-85)


Input: The major myosin-binding domain of skeletal muscle MyBP-C (C protein) resides in the COOH-terminal, immunoglobulin C2 motif.

myosin-binding domain

skeletal muscle MyBP-C

C protein

immunoglobulin C2 motif


Input: Our results indicate that periseizure lipid accumulation is related to cortical oxygenation.


Input: We conclude that the QLMI questionnaire has good potential as an instrument for assessing QL in post-AMI patients and that it can be successfully self-administered.


Input: Most smokers would prefer to quit smoking on their own.


Input: The inhibitory response to taps is essentially a protective reflex which probably serves to reduce the activity of the jaw-closing muscles when one bites unexpectedly on hard objects.