Input: Effects of dioxins on thyroid function in newborn babies.


Input: cDNA clones encoding Arabidopsis thaliana and Zea mays mitochondrial chaperonin HSP60 and gene expression during seed germination and heat shock.

Zea mays mitochondrial chaperonin HSP60


Input: The single site of glycosylation is located near the C-terminus in the N-glycosylation sequon-Asn-Cys-Ser-in which Cys forms part of a disulphide bridge.


Input: The pulmonary toxic events induced by acute nitrogen dioxide (NO) 2 exposure were studied in the rat to develop an inhalation model to investigate therapeutic measures.


Input: The pulmonary effects observed, became more pronounced with increasing NO2 concentrations (0, 25, 75, 125, 175 or 200 ppm, 1 ppm NO2 = 1. 88 mg m-3 NO2) and exposure times (5, 10, 20 or 30 min).


Input: Interaction of H-2Eb with an IAP retrotransposon in the A20/2J B cell lymphoma.

IAP retrotransposon


Input: Gestational trophoblastic diseases: recent advances in the understanding of cytogenetics, histopathology, and natural history.


Input: With the exception of mutants that remove the membrane anchor domain, all of the mutant glycoproteins retained the ability to cause fusion of CD4-bearing cells.


Input: The subunit protein of curli was highly homologous at its amino terminus to SEF-17, the subunit protein of thin, aggregative fimbriae of Salmonella enteritidis 27655 strain 3b, suggesting that these fibres form a novel class of surface organelles on enterobacteria.

curli


Input: Substitution of the DR1 beta chain with H-2E beta k led to a dramatic loss of recognition; alpha chain substitution had a less marked effect.

DR1 beta chain

H-2E beta k


Input: This negative regulatory pathway may be important for determining cell fate or maintaining an inducible state in the ventroposterior region of the embryo.


Input: The distal portion of the rat insulin I gene 5'-flanking DNA contains two sequence elements, the Far and FLAT elements, that can function in combination, but not separately, as a beta-cell-specific transcriptional enhancer.

rat insulin I gene 5'-flanking DNA


Input: The deduced amino acid sequence exhibited 98% identity to the human cellular transglutaminase sequence.


Input: Repeated efforts to isolate recombinant baculoviruses containing a wild-type kinase failed, whereas recombinants expressing a nonfunctional kinase with a catalytic domain II mutation were readily isolated.


Input: Finally, we determined that the P68 amino terminus was both necessary and sufficient for binding dsRNA as we were able to transfer dsRNA-binding properties to a reporter gene product previously unable to bind RNA.


Input: From August 1989 to October 1990, 83 pregnant Chinese women were the subjects for measuring the levels of plasma functional antithrombin III (AT III) activity.

antithrombin III

AT III


Input: Visual acuity may be decreased by transient changes in refractive error caused by sulfonamides, the antifungal agent metronidazole, thiazide diuretics, and carbonic anhydrase inhibitors.

carbonic anhydrase


Input: Currents aspects of H2 receptor antagonists in the treatment of ulcers

H2 receptor


Input: In addition, a 21-mer subrepeat structure is also present in each unit.


Input: Sequencing revealed one large open reading frame encoding a 39-kDa protein.


Input: These sites are also potential keratan sulfate attachment sites.


Input: We propose that plasmids of the pLS1 family (pE194, pADB201, and pLB4) share functional and structural characteristics for the regulation of their copy numbers.


Input: Perturbation of dNTP pools also affected the frameshift fidelity of the replicative yeast DNA polymerase alpha.

yeast DNA polymerase alpha


Input: Differential expression of the " B " subunit of the vacuolar H (+)-ATPase in bovine tissues.

vacuolar H (+)-ATPase


Input: In addition, the hGCSFR gene was chromosomally localized by Southern blot analysis of its segregation pattern in a panel of rodent-human hybrid DNAs using the radiolabeled cDNA probe.

hGCSFR gene


Input: We have isolated and characterised a differentially-regulated gene family in the protozoan parasite Leishmania major.


Input: At some sites,% T is greatly increased by Cl-concentrations up to 1 M, while at other sites% T is reduced or unaffected by these conditions.


Input: Necrosis appears 6 h after TA infusion, being 5. 77% in extent after 12 h, 14. 9% after 24 h and animals die with an area of 29. 5% necrosis.


Input: In summary, the segments of C3 represented by amino acid residues 1082-1118, 1117-1155, 1234-1294 and 1312-1404 accommodate C3 (D) epitopes that are expressed by erythrocyte-bound C3 fragments, but not by the corresponding fluid-phase fragment, whereas the segments spanning residues 973-1026 and 1477-1510 contain C3 (D) epitopes that are exposed exclusively in denatured C3 and therefore hidden in physiological fragments of the protein.

C3 (D) epitopes

C3 fragments

C3 (D) epitopes


Input: These exons, further identified as exons 9, 10, and 11, together encode the 37 amino acid residues present in alpha s1-casein variant A but missing in variant F.

alpha s1-casein variant A


Input: We also report here the complete structural organization of the goat alpha s1-casein transcription unit, deduced from polymerase chain reaction experiments.

goat alpha s1-casein transcription unit


Input: Homodimers of the three proteins specifically recognize the G-box motif, with GBF1 and GBF3 binding symmetrically to this palindromic sequence.


Input: The hydrophobicity plot of NHE-3 is very similar to that of NHE-1 and NHE-2.


Input: The initial translation protein encoded by the cDNA is 53, 932 kDa and possesses a hydrophilic amino acid composition with glutamic acid comprising 22% of the total amino acid residues.


Input: Each group received 15 ml/kg of either 6% pentafraction, 6% pentastarch, or plasma followed two hours later by 1. 5 micrograms/kg/0. 5 hr E.


Input: Genetic and biochemical evidence suggests that v-Crk can induce transformation of chicken embryo fibroblasts by influencing the activity of cellular proteins involved in growth regulation.

v-Crk


Input: We have constructed, using synthetic DNA oligonucleotides, a U14 snRNA gene which has been positioned behind a T7 RNA polymerase promoter site and then inserted into a plasmid.

U14 snRNA gene

T7 RNA polymerase promoter site


Input: The carcinoma was restricted within the epithelium in one, the mucosal layer in five, and the submucosal layer in two.


Input: In addition, C/EBP beta and C/EBP gamma readily heterodimerize with each other as well as with C/EBP alpha.

C/EBP beta

C/EBP gamma

C/EBP alpha


Input: In contrast, tobacco GS-2 is composed of subunits of identical size in all organs examined.

tobacco GS-2


Input: Between acoR and acoXABC, two different types of sequences with dual rotational symmetry [CAC-(N11 to N18)-GTG and TGT-(N10 to N14)-ACA] were found; these sequences are similar to NtrC and NifA upstream activator sequences, respectively.

acoR

acoXABC

NtrC

NifA upstream activator sequences


Input: Although the effects of the calcium supplement or calcium antagonist alone were significant, such hypotensive responses were not optimal or predictable or clearly dose-dependent.


Input: C., Sun, J., Hsu, M.-Y., Vallejo-Ramirez, J., Inouye, S., and Inouye, M.


Input: Surprisingly, the full-deletion mutant showed a strong block in virus release, suggesting that NC is involved in virus assembly.

NC


Input: Furthermore it was suggested that FK506 plasma levels were concerned with the appearance of side effect.


Input: Thirty percent of patients were tapered off all steroids, and the average steroid dose in the group who received steroids was 8. 6 mg of prednisone per day.


Input: Thus, cibenzoline is an effective antiarrhythmic agent with a favourable pharmacokinetic profile that may be considered with other class I drugs in patients requiring therapy for high risk arrhythmias.


Input: T antigen contains four H-2Db-restricted cytotoxic T lymphocyte (CTL) recognition epitopes that are targets for CTL clones Y-1, Y-2, Y-3, and Y-5.

T antigen


Input: The method requires a reversed-phase column and a paired-ion technique to separate docusate sodium from other components.


Input: Here we demonstrate that the protein product of the ref-1 gene stimulates the DNA binding activity of Fos-Jun heterodimers, Jun-Jun homodimers and Hela cell AP-1 proteins as well as that of several other transcription factors including NF-kappa B, Myb and members of the ATF/CREB family.

ref-1 gene

Fos

Jun

Jun

Jun

AP-1 proteins

NF-kappa B

Myb

ATF

CREB


Input: The pulpal tissues of the permanent mandibular molars were amputated and then dressed with calcium hydrate.


Input: Northern blot analyses demonstrate that 3. 9-and 5-kilobase mRNAs corresponding to the cDNA were present in all tissues examined, suggesting that the protein it encodes performs a housekeeping function.


Input: The ARG SH2 domain exhibited relatively weak affinity for BCR and was determined to bind about 10-fold less strongly than the ABL SH2 domain.

ARG SH2 domain

BCR

ABL SH2 domain


Input: We analyzed an EBV B-cell clone, E29. 1, derived from an 11 week-old embryo, and secreting both IgM kappa and IgM lambda.

IgM kappa

IgM lambda


Input: Interestingly, this activation occurred only when the regions were cloned in the same relative orientation in which they exist on wild-type pCF10.


Input: In rats, we examined the effect of an omentum wrapping on the vascularization of the trachea and on regeneration of the mucosal epithelium in the very early stage after free tracheal grafting.


Input: To study a possible functional role of this putative chicken ICS, an oligonucleotide spanning the upstream sequences of the BF-IV gene (-174/-194) was cloned singly or in multiple copies before the herpes TK promoter controlling the chloramphenicol acetyl transferase (CAT) gene (pBLCAT2).

ICS

BF-IV gene

TK promoter

chloramphenicol acetyl transferase

CAT


Input: In general, two separate high-performance liquid chromatographic runs were performed, one for the gamma-aminobutyric acid determination and one for the determination of the monoamines.


Input: We report the successful use of electroconvulsive therapy for treatment of severe depression in a young man with adult GM2 gangliosidosis.


Input: Through Southern blot analyses of DNA from backcross and cogenic mice, recombinant inbred strains, and somatic cell hybrids, the genetic loci that produce the cyclin B1-related sequences (designated loci Cycb1-rs1 to Cycb1-rs9) were mapped on mouse chromosomes 5, 1, 17, 4, 14, 13, 7, X, and 8, respectively.

cyclin B1-related sequences

loci Cycb1-rs1


Input: Again residue Glu-381 of beta was notably reduced and no missing residue from the epsilon peptide could be identified, but the peptide sequence limited the possible choices to Ser-106, Ser-107, or Ser-108.


Input: Porcelain to dentin bond strength with a dentin adhesive.


Input: TBPf is defined as a quotient of the difference of the first and the second measurement: TBPf = (P1-P2)/(A1-A2).


Input: It was concluded that Scotchbond 2 and Prisma Universal Bond 2 are effective and are the dentine bonding agents of choice.


Input: The neurohypophysial vasopressin and oxytocin content was bioassayed by pressor effect following Dekanski or milk-ejection activity in vitro following van Dongen and Hays, respectively.

vasopressin

oxytocin


Input: Comments are given on the present status of regulations concerning water in swimming pools and baths--1991--(in connection with the KOK regulations--1972--and the Federal German standard [DIN] No.


Input: If no reply was received, telephone contact or home visits were made.


Input: The treatment group also showed in vivo T-cell activation with an initial lymphopenia followed by a rebound lymphocytosis and upregulation of the subset markers CD25 (interleukin 2 receptor) and CD45RO (T-memory cells).

interleukin 2 receptor


Input: Urease activity, judged as the amount of ammonia production from urea, could be measured at 25 ng per tube (S/N = 1. 5) with Jack bean meal urease.

Urease

Jack bean meal urease


Input: Although a wide range of cognitive functions had been tested, all but one seizure occurred during assessment of memory performance.


Input: The experiments show that it is the micromilieu of the alveoli and the condition of the AM (certain physiological activation states, such as phagocytic activity) that essentially determine the degree of recovery.


Input: A cDNA library of tumour cells was screened with an interleukin 2 gene-specific probe.

interleukin 2


Input: Our experiments suggest that the SCL gene can be a target for the erythroid transcription factor GATA-1 and that the SCL gene product serves as a positive regulator of erythroid differentiation.

SCL gene

erythroid transcription factor GATA-1

SCL gene product


Input: Complexes containing wild-type and either his175 or his273 mutant p53 proteins are completely unable to bind to the RGC DNA sequence.

his175 or his273 mutant p53 proteins

RGC DNA sequence


Input: These temperature-and cold-sensitive strains were used to prepare extracts deficient in BRF1 activity and were tested for transcriptional activity by RNA polymerases I, II, and III in vitro.

RNA polymerases I, II, and III


Input: These results lead us to hypothesize that a single multisubunit TFIID protein supports transcriptional stimulation by diverse activation domains and from a TATA-less promoter.

multisubunit TFIID protein


Input: Clone pSRc200 hybrid selected an mRNA that on cell-free translation produced a 38-kDa polypeptide.


Input: From these results, CBF-A is a novel CArG box-, ssDNA-and RNA-binding protein, as well as a repressive transcriptional factor.

CBF-A

ssDNA-and RNA-binding protein


Input: Cleavage by the intron-encoded enzyme (I-CreI) occurs 5 bp and 1 bp 3' to the intron insertion site (in the 3'-exon) in the top (/) and bottom (,) strands, respectively, resulting in 4-nt single-stranded overhangs with 3'-OH termini.

I-CreI


Input: Surprisingly, the Xenopus U7 gene contains two adjacent octamer-binding motifs located only 12 and 24 bp upstream from the PSE, instead of the usual location around 150-200 bp upstream.

Xenopus U7 gene

PSE


Input: The results support earlier reports that collagenase inhibitors are useful in controlling blister formation in recessive dystrophic epidermolysis bullosa.

collagenase


Input: In humans, four AMP deaminase variants, termed M (muscle), L (liver), E1, and E2 (erythrocyte) can be distinguished by a variety of biochemical and immunological criteria.

AMP deaminase variants

M

L


Input: Western blot analyses detect anti-E-specific immunoreactivity in affinity-purified extracts derived from the bacterial expression of a truncated AMPD3 cDNA.

anti-E

truncated AMPD3 cDNA


Input: These results demonstrate that endogenous N-methylation of salsolinol into N-methylsalsolinol occurs in the brain in vivo.


Input: DR1 molecules purified from human lymphoblastoid cell lines could specifically bind to these peptide sequences expressed on the phage surface.

DR1 molecules


Input: This article describes the collaborative care of the woman participating in maternal blood donation for intrauterine transfusion.


Input: Chronic hepatitis B in adopted Romanian children.


Input: Behind the ATPase cluster, two open reading frames were detected that are not homologous to any known chloroplast gene.

ATPase cluster


Input: Therefore, recombinant human Ads that express noninfectious HIV or other microbial proteins are attractive vaccine candidates.


Input: Alignment of the selected sequences allowed us to predict a consensus sequence for binding of the individual homodimeric Rel-related proteins, and DNA-protein binding analysis of the selected DNA sequences revealed sequence specificity of the proteins.

Rel-related proteins


Input: Using either a p50-or p65-selected kappa B motif, which displayed differential binding with respect to the other protein, little to no binding was observed with the heterodimeric NF-kappa B complex.

p65-selected kappa B motif

heterodimeric NF-kappa B complex


Input: However, a cosmid clone containing the entire mouse alpha 1 (I) gene, including 3. 7 kb of 5'-and 4 kb of 3'-flanking DNA, was expressed at reduced levels in fibroblasts overexpressing oncogenic ras.

mouse alpha 1 (I) gene

oncogenic ras


Input: To define transcriptional control elements responsible for muscle-specific expression of the human myoglobin gene, we performed mutational analysis of upstream sequences (nucleotide positions-373 to + 7 relative to the transcriptional start site) linked to a firefly luciferase gene.

human myoglobin gene

firefly luciferase gene


Input: Sequencing analysis has shown that each rap1t allele contains a nonsense mutation within a discrete region between amino acids 663 and 684.

rap1t allele


Input: By screening a Y1 cell cDNA library with the DNA-binding region of the H-2RIIBP nuclear hormone receptor cDNA, we isolated a cDNA that is selectively expressed in steroidogenic cells.

H-2RIIBP nuclear hormone receptor cDNA


Input: Autopsy demonstrated good survival of the transplanted cells with good integration with the brain of the recipient and traces of positive immunocytochemical reaction for tyrosine hydroxylase.

tyrosine hydroxylase


Input: The technique of the TEE visualization of the proximal coronary arteries is described.


Input: The sequence of this region shows high G + C content (62%), which is particularly emphasized in the 200 bp upstream from the mRNA start (80% G + C).


Input: PaO2 threshold was determined through an indwelling O2 sensor catheter.


Input: By using lambda gt11 expression cloning with oligonucleotides corresponding to the human immunodeficiency virus 1 TATA element, we report the identification of a cellular protein with a calculated molecular mass of 123 kDa that we designate TATA element modulatory factor (TMF).

TATA element modulatory factor

TMF


Input: Blood levels of melatonin, serotonin, cortisol, and prolactin in relation to the circadian rhythm of platelet serotonin uptake.

prolactin


Input: We couldn' t detect any effect of n-3 FA supplementation on total cholesterol, HDL cholesterol, LDL cholesterol, apo A1, Lp (a), HbA1C, glucose, fibrinogen, factor VIII, antithrombin III, plasminogen activator inhibitor, tissue plasminogen activator and von Willebrand factor concentration, on bleeding time or on systolic or diastolic blood pressure.

HDL cholesterol

LDL cholesterol

apo A1

Lp (a)

fibrinogen

factor VIII

antithrombin III

plasminogen activator inhibitor

tissue plasminogen activator

von Willebrand factor


Input: In 8 healthy volunteers there were no significant differences in AUC, peak plasma concentrations or time to peak concentration when OXC was administered either with or without ERY.


Input: Using 5 ng/mL as the cutoff, the sensitivity of CEA was 68%.

CEA


Input: Rolandic spikes and cognitive function.


Input: The effect of sodium 18 beta-glycyrrhetate (SGA) on experimental arrhythmia was investigated.


Input: Thus, chronic hematocrit decrease induced by H or P resulted in a significant fall in blood pressure compared to control (201 +/-3 v 175 +/-4, 167 +/-4 mm Hg, respectively; P <. 05).


Input: The effects of diltiazem were stereoselective, thus the potentiation induced by d-cis diltiazem was significantly greater in all cases than that induced by l-cis diltiazem, which suggests that calcium channel blockade plays a role in these interactions.


Input: Substitution of either Val33 (by Gly) or Gly28 (by Ser), two of the most conserved residues in all protein kinases, resulted in enzyme with marginally detectable activity.


Input: Significance of the biopsy site of the latissimus dorsi muscle for fiber typing.


Input: The TIMP (-59/-53) AP1 site is a promiscuous motif that binds c-Fos/c-Jun AP1 translated in vitro and is an effective competitor for binding of nuclear AP1 factors to the consensus TRE, but in addition it binds factors that do not associate with the consensus TRE.

TIMP

c-Fos

c-Jun AP1

nuclear AP1 factors


Input: Involvement of AP1 and PEA3 binding sites in the regulation of murine tissue inhibitor of metalloproteinases-1 (TIMP-1) transcription.

PEA3 binding sites

murine tissue inhibitor of metalloproteinases-1


Input: Of the serum neutralizing (SN) antibody negative calves 89. 7% (26/29) and 92. 8% (90/97) developed SN antibody 1 month after intranasal and intramuscular vaccination, respectively.

serum neutralizing (SN) antibody

SN antibody


Input: Fractionation of crude nuclear extracts by heparin-agarose chromatography indicates that PCAT-1 is more prevalent in extracts prepared from salt-stressed leaf tissue.


Input: A controlled trial of recombinant human granulocyte-macrophage colony-stimulating factor after total body irradiation, high-dose chemotherapy, and autologous bone marrow transplantation for acute lymphoblastic leukemia or malignant lymphoma.

recombinant human granulocyte-macrophage colony-stimulating factor


Input: These data demonstrate that DMVA does not cause more myocardial trauma than CPB when used to provide resuscitative circulatory support.


Input: The IgG subclass profile of untreated coeliac disease was found to be the same as in healthy controls (IgG1 approximately IgG2 > IgG3 > IgG4), with only the magnitude of the individual subclass responses being increased in coeliac patients.

IgG


Input: Examination of ANCA is not only a significant contribution towards a more accurate diagnosis of renal vasculitis, but also an indicator of the activity of the disease and thus of the effectiveness of immunosuppressive treatment.

ANCA


Input: On the other hand, total pinealectomy in these already sympathectomized blinded rabbits always resulted in a substantial deceleration of the rhythms (mean delta tau = + 0. 23 h).


Input: Cicatricial pemphigoid is an autoimmune systemic disease characterized by chronic conjunctival cicatrization.


Input: The effects of two levels of caffeine ingestion on excess postexercise oxygen consumption in untrained women.


Input: The distinguishing features involved eight amino acid changes, including a single lysine deletion relative to a primate consensus sequence in the first complementary-determing region of V1J1.


Input: The in vivo profile of ZFH-2 in the larval CNS shows intriguing overlap with DDC in specific serotonin and dopamine neurons.

DDC


Input: Unlike the introns of other duplicated ribosomal protein genes which are highly diverged, the duplicated S13 genes have two nearly identical DNA sequences of 25 and 31 bp in length within their introns.

ribosomal protein genes

S13 genes


Input: In a prospective, randomized clinical trial we compared the efficacy of subcutaneously (SC) administered (every 8 h) calcium heparin to intravenous (IV) sodium heparin in the treatment of proximal deep-vein thrombosis (DVT).


Input: The highest prevalence of reported pet allergy, chronic cough, wheeze, attacks of shortness of breath with wheezing, and doctor-diagnosed asthma was found in children who had pets in the past but not anymore.


Input: Therefore, it would be advantageous to identify such persons and treat them preferentially.


Input: On the basis of these unique properties, the newly characterized hemagglutinin has been termed Limulus 18K agglutination-aggregation factor (18K-LAF).

hemagglutinin

Limulus 18K agglutination-aggregation factor


Input: The shift to the nonpermissive temperature is accompanied by the loss of guanyl nucleotide-dependent activity of adenylylcyclase in vitro.

adenylylcyclase


Input: Clin.


Input: The data indicate that the minimal catalytic domain of Nmt1p is located between Ile59--> Phe96 and Gly451--> Leu455.


Input: It corresponds to the complete mitochondrial presequence and the lipoyl-bearing domain that are encoded by exons I through IV of the functional E2 gene.

E2 gene


Input: Human neutrophil response to short-term exposure to F-75 cobalt-based alloy.


Input: Disruption of microtubules did not affect the fidelity or kinetics of vacuolar protein sorting, indicating that Vps1p function is not dependent on microtubules.


Input: A mutant form of Vps1p lacking the entire GTP-binding domain interfered with vacuolar protein sorting in wild-type cells.


Input: According to out field research, the tick fauna was very rich throughout that area, and it was permissible enough to determine ticks as the vectors, based on arising of anti-SF group rickettsiae (SFGR) antibody in mice inoculated with some tick emulsions, findings of rickettsiae reactive to patient sera or a species-specific monoclonal antibody to JSFR in the hemolymph cells of some ticks, and electron microscopical observations of SFGR in various internal organs including the salivary gland of ticks.

anti-SF group rickettsiae

SFGR

JSFR

SFGR


Input: Nucleotide sequence and transcriptional analysis of the polyhedrin gene of Spodoptera exigua nuclear polyhedrosis virus.

polyhedrin gene


Input: Validation of automated systems--system definition.


Input: As a consequence of dark rearing, the numerical density of cortical neurons in area 17 amounted to about double of the value observed in normally reared kittens and was also significantly higher in area 18.


Input: These results suggest that decreased class I enhancer activity in Ad12-transformed cells may, at least in part, be due to the higher levels of an enhancer-specific factor, possibly acting as a repressor.


Input: A second domain, located in the C-terminal 437 amino acids of IE1, is required for inhibitory and DNA-binding activities.


Input: In order to investigate the blood compatibility of autogenous vein graft (AVG), changes in prostacyclin (PGI2) production following harvesting and arterial implantation were studied experimentally.


Input: Subcutaneous administration of the somatostatin analogue, octreotide, 100 micrograms thrice daily, resulted in a sustained improvement in diarrhoea and disappearance of faecal incontinence without reducing calcitonin levels.

somatostatin

calcitonin


Input: 205, 285-290] and was subsequently cloned and sequenced [J.


Input: Nonreplicating vaccinia vector efficiently expresses recombinant genes.


Input: Interferon type I in protective body reactions in an experimental Klebsiella infection

Interferon type I


Input: No other changes in hematopoietic differentiation status were observed in association with Id-SCL expression.

Id-SCL


Input: For pressure greater than 121 atm abs, an increased excitability of the tadpoles made it difficult to distinguish the righting reflex from involuntary movements.


Input: One air embolism occurred; this was the only filter-or retrieval-related complication.


Input: The 5' region of ADH5 contains consensus binding sites for the transcriptional regulatory proteins, Sp1, AP2, LF-A1, NF-1, NF-A2, and NF-E1.


Input: These data indicate that RNK-Met-1 is a serine protease with unique activity that is expressed in the granules of large granular lymphocytes.

serine protease


Input: Purification and cloning of a novel serine protease, RNK-Met-1, from the granules of a rat natural killer cell leukemia.

serine protease


Input: We describe here 17 dominant GCN2 mutations that lead to derepression of GCN4 expression in the absence of amino acid starvation.

dominant GCN2 mutations


Input: Administration of growth hormone leads to faster growth, but also faster bone maturation.

growth hormone


Input: Comparisons with the available amino acid residue (aa) sequence information from the complete CPMV RNA 1 sequence and the partial sequence of red clover mottle virus RNA 1 suggest that CPSMV RNA 1 specifies the expected set of five mature proteins: 32K proteinase cofactor, 58K presumed helicase, VPg 5'-linked protein of the genomic RNAs, 24K proteinase, and 87K presumed polymerase, separated by four cleavage sites.

CPMV RNA 1 sequence

red clover mottle virus RNA 1

CPSMV RNA 1

32K proteinase cofactor

58K presumed helicase

VPg 5'-linked protein

24K proteinase

87K presumed polymerase


Input: In addition, the utility of beta 2 transferrin assay in the diagnosis of cerebrospinal fluid otorrhea is presented.

beta 2 transferrin


Input: The addition of diatrizoate to the IPRK led to a dose-dependent biphasic change in RPF and GFR characterized by an initial transient increase followed by a marked and sustained decrease.


Input: To prepare for analyses with the family variables, we next present descriptive data based on separate principal components analysis (PCA) and multidimensional scaling analysis (MDS) of 14 self-reported health scores for husbands and for wives.


Input: The structural genes encoding glyceraldehyde-3-phosphate dehydrogenase (GAPDH), 3-phosphoglycerate kinase (PGK) and the N-terminal part of triosephosphate isomerase (TIM) from mesophilic Bacillus megaterium DSM319 have been cloned as a gene cluster (gap operon) by complementation of an Escherichia coli gap amber mutant.

glyceraldehyde-3-phosphate dehydrogenase

GAPDH

3-phosphoglycerate kinase

PGK

triosephosphate isomerase

TIM

gap operon

gap amber mutant


Input: Pseudomonas aeruginosa exotoxin A: its role in retardation of wound healing: the 1992 Lindberg Award.

Pseudomonas aeruginosa exotoxin A


Input: Laboratory studies showed that the direct fluorescent-antibody kits were the least sensitive in this case and did not detect fewer than 10 (4) elementary bodies per ml, while most ELISA kits detected between 130 and 600 elementary bodies per ml.


Input: To study the significance of these domains and the overall evolutionary conservation of the gene, the homolog from Drosophila melanogaster was isolated by low stringency hybridizations using two flanking probes of the human ERCC3 cDNA.

human ERCC3 cDNA


Input: Mono-ADP-ribosylation is a reversible modification of proteins, with NAD: arginine ADP-ribosyltransferases (EC 2. 4. 2. 31) and ADP-ribosylarginine hydrolases (EC 3. 2. 2. 19) catalyzing the opposing reactions in an ADP-ribosylation cycle.

arginine ADP-ribosyltransferases

EC 2. 4. 2. 31

ADP-ribosylarginine hydrolases

EC 3. 2. 2. 19


Input: For this reason, the particle forming capacity of derivatives of the HIV-1 group specific core antigen p55 gag was assayed and compared dependent on various expression systems: recombinant bacteria, vaccinia-and baculoviruses were established encoding the entire core protein p55 either in its authentic sequence or lacking the myristylation consensus signal.

HIV-1 group specific core antigen p55 gag

core protein p55


Input: The tramtrack (ttk) gene of Drosophila encodes 69-kDa and 88-kDa proteins through alternative splicing of the primary ttk transcript.

tramtrack

ttk

ttk transcript


Input: Removal of beta 2-microglobulin by hemodialysis and hemofiltration: a four year follow up.

beta 2-microglobulin


Input: Removal of beta 2-microglobulin by hemodialysis and hemofiltration: a four year follow up.

beta 2-microglobulin


Input: Adapromine was established to evoke a decrease of the amplitude of the dominant peak and dominant theta-activity in power spectra of the EEG in the cortex and hippocamp, with an increase of rapid wave activity in the beta 2 range in the right cortex and hippocamp.


Input: These sequences were then used to clone the full-length genes from a yeast genomic library.


Input: GAL4-VP16-mediated antirepression required an auxiliary factor, denoted as a co-antirepressor, which was partially purified from Drosophila embryos.


Input: After 28 days of haloperidol treatment, similar changes were observed for delta, together with an increase of alpha 1, and a decrease of fast beta.


Input: Four ruminally and duodenally cannulated Hampshire wethers were used in a 4 x 4 Latin square experiment to determine whether linoleoyl methionine and calcium linoleate would increase duodenal flow of unsaturated fatty acids (C18: 2 + cis C18: 1).


Input: Truncated ICSBP lacking the first 33 amino-terminal amino acids fails to bind to the ICS, indicating that at least part of the DNA binding domain is located within the well conserved amino terminus.

Truncated ICSBP

ICS


Input: Therefore, ICSBP may be involved in maintaining submaximal transcriptional activity of IFN-inducible genes in hematopoietic cells.

ICSBP

IFN


Input: A case of chronic hepatitis C with primary hypothyroidism manifested during interferon treatment

interferon


Input: Dynamic decision making: human control of complex systems.


Input: A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes.

coiled-coil related protein


Input: Abstracts.


Input: These results indicate a possible involvement of endogenous opioid peptides in the cardiac effects due to myocardial ischaemia and reperfusion, mediated by opiate receptors through opiate antagonism.

opiate receptors


Input: Since CENP-B gene is conserved in mammalian species and CENP-B boxes are found also in mouse centromere satellite DNA (minor satellite), this sequence-specific DNA-protein interaction may be important for some kind of common centromere function.

CENP-B gene

CENP-B boxes


Input: Interestingly, a portion of the tail domain (aa, 1, 094-1, 830) shares 58% amino acid sequence identity with a 723-aa protein from mouse brain reported to be a glutamic acid decarboxylase.

glutamic acid decarboxylase


Input: However, in the subgroup with normal Ht (< 0. 45 l/l; n = 201) there was a significant reduction (p < 0. 05) of the mortality after 3 months (27% and 16%, respectively) and an increase of independence at home (35% and 48%, respectively) due to a reduction of the viscosity by means of haemodilution with albumin (a specific viscosity effect in the normovolaemic group).

albumin


Input: Distribution and changing morphological course


Input: The appropriate use and benefits of bile acid sequestrants, nicotinic acid, fibric acids, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, and probucol are individually discussed, whereas nonpharmacologic approaches used in conjunction with the drugs are recommended emphatically.

3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase


Input: This may result in more reabsorption and hence reduced renal clearance.


Input: The major pathological findings of the placenta were prematuration and hypoplasia.


Input: Green pepper significantly inhibited N-nitrosothiazolidine-carboxylic acid formation relative to ascorbic acid alone.


Input: A genomic clone, pTt21, containing DNA apparently transcribed specifically in Trypanosoma cruzi trypomastigotes, was obtained by differentially screening a genomic library with trypomastigote and epimastigote cDNA.


Input: Assay of urea by immobilized urease coupled to a differential pH-meter.

urease


Input: RESULTS: In the AGA group, both fetal and maternal serum prolactin concentration increased significantly with gestation (P < 0. 001 and P < 0. 01, respectively).

prolactin


Input: One phage clone contains a junction between alpha satellite DNA and a novel low-copy repeated sequence.


Input: The 5'-flanking region of the human lactoferrin gene was isolated from a human placental genomic library.

human lactoferrin gene


Input: Therefore, the molecular mechanisms of the estrogen action that govern the lactoferrin gene expression differ between mouse and human.

lactoferrin gene


Input: The CEM receives registration updates via an HL7 message and evaluates data dependencies in rules via an interface to the relational database.


Input: Magnetic resonance spectroscopy (MRS) and imaging (MRI) are now well established techniques for the study of cellular metabolism and gross structure of muscle.


Input: Simultaneously a greater NA was found with no change in plasma epinephrine response.


Input: We investigated the diagnostic value of a new in vitro test, Pharmacia CAP System (Pharmacia Diagnostics AB, Uppsala, Sweden), for the quantitative measurement of allergen-specific IgE antibodies by comparison with RAST in 2 groups of patients, 71 atopic and 48 non-atopic.

allergen-specific IgE antibodies


Input: Patients receiving VPA showed differences in attention, visuomotor performance, verbal span and sensory discrimination tasks at T1, in visuomotor performance at T2 and in spatial span at T3, whereas no differences were detected at T4.


Input: We found that the gene segment containing the mu m poly (A) signals, along with 536 bp of downstream flanking sequence, acted as a transcription terminator in both myeloma cells and L cell fibroblasts.


Input: Alena is a nurse in Prague--she dreams of higher wages and a trip across the ocean


Input: Dopamine neurons in subjects that received 6-OHDA were protected by pre-treatment with GBR-12909.


Input: The results of this study demonstrate that strongyloidiasis was the cause of sudden death.


Input: A second large group of disorders in pregnancy is caused by effects of infections of the mother without pathogens being transmitted to the embryo or the placenta.


Input: Four short nucleotide sequences (boxes I to IV) contribute to the light responsiveness of the parsley chalcone synthase promoter.

parsley chalcone synthase promoter


Input: The case described is that of a 72-year-old man with ochronosis who suffered a hyperextension injury to his spine in a fall, resulting in a fracture through an ankylosed L2-L3 disk space.


Input: The mean blood flow in the penile foreskin was estimated to be 15 ml/min/100 g and it increased to 150-200% after the induction of anesthesia, and then decreased to 72% at the tip of the created parameatal foreskin flap.


Input: Exogenous LHRH is also known to facilitate mating behavior in several species.

LHRH


Input: The first 146 consecutive patients treated with EVL during the period from August, 1986 to July, 1989 are reported.


Input: Replacing the aspartic acid with a lysine but not with an alanine or valine residue allowed formation of disulfide-linked dimers.


Input: During V-A bypass, hemodynamics were stable.


Input: Greater rupture force was required in the adult pigs than in the young pigs.


Input: At rest AFF was significantly higher in UT (29%) as compared to AT (25%) and UEA (25%).


Input: We investigated the smoking habits of relapsers 1 year after quitting in a smoking cessation trial using nicotine or placebo patches.


Input: Exposure to hepatitis B virus in the general population of Hisayama, Japan: significance of isolated antibody to hepatitis B surface antigen in general population.

hepatitis B surface antigen


Input: Because of this latter phenomenon, we were able to identify a particular cysteine motif that was repeated multiple times in Dfurin2 but present only twice in mammalian furin.

mammalian furin


Input: On the other hand, neither phosphate buffered saline injection into the ES nor primary KLH challenges of the ES were capable of elevating the threshold level and changing the latency.

KLH


Input: A newly developed broad-spectrum fluoroquinolone, levofloxacin (LVFX, DR-3355), was evaluated in vitro and in vivo in comparison with ciprofloxacin (CPFX), ofloxacin (OFLX) and norfloxacin (NFLX).


Input: The mean serum creatinine levels were similar at one year (SPK 1. 8, KTA 1. 9 mg/d). (ABSTRACT TRUNCATED AT 250 WORDS)


Input: Model predictions were in accord with the nine-year survival experience of women in the HIP trial, and, with the exception of women 40-44 years old, with HIP data on 18-year survival.


Input: High-resolution computed tomography in the diagnosis of miliary tuberculosis.


Input: Previously, we showed that SNF2, SNF5, and SNF6 function interdependently in transcriptional activation, possibly forming a heteromeric complex.


Input: We show that LexA-GAL4 and LexA-Bicoid fusion proteins are both dependent on SNF2, SNF5, and SNF6 for activation of target genes containing one or multiple lexA operators.

LexA

LexA

Bicoid

lexA operators


Input: George T.


Input: A lambda gt10 cDNA library was constructed from poly (A) + RNA of young green leaves of spinach.


Input: NE and PR3 assist in the destruction of phagocytosed microorganisms, cleave the important connective-tissue protein elastin, and generate chemotactic activities by forming alpha 1-proteinase inhibitor complexes and elastin peptides.

NE

connective-tissue protein elastin

alpha 1-proteinase inhibitor complexes

elastin peptides


Input: Selected topics in pediatric ultrasonography--1992.


Input: Methods included 24-hour dietary recall, menu weights, and recipe analysis.


Input: Factors associated with afterdrop included age, end-of-surgery temperature (both positively) and body mass (negatively).


Input: Both GH deficiency and impaired spinal growth may result in short stature, whereas the occurrence of early puberty in association with GH deficiency reduces the time available for GH therapy.

GH

GH

GH


Input: By contrast, d (T2AG3T) and d (T2G4T) form only the G-quadruplex monomer structures independent of K cation concentration as reported previously [Sen, D., & Gilbert, W.

d (T2AG3T)

d (T2G4T)


Input: Differentiating among renal stones.


Input: IFI 16 mRNA was found to be constitutively expressed in lymphoid cells and in cell lines of both the T and B lineages.

IFI 16 mRNA


Input: Mitochondria-lytic action of warfarin in lymphocytes.


Input: Exon-intron junctions in the human and rat AdoMet decarboxylase genes were in identical positions except that exons 6 and 7 of the human gene formed a single exon in the rat gene.

rat AdoMet decarboxylase genes


Input: Interferon-alpha-induced gene expression: evidence for a selective effect of ouabain on activation of the ISGF3 transcription complex.

Interferon-alpha

ISGF3 transcription complex


Input: Moreover, LD50 in mice of RP-170 (4. 3 g/kg on i. v.) was increased to 5. 2 g/kg by oral administration.


Input: Among the few proteins of the eukaryotic nucleolus that have been characterized, four proteins, nucleolin, fibrillarin, SSB1 and NSR1, possess a common structural motif, the GAR domain, which is rich in glycine and arginine residues.

nucleolin

fibrillarin


Input: Thus, this study provides evidence that a novel, ubiquitous factor (HF-1a) and a muscle factor (HF-1b/MEF-2) can form a novel, E-box-independent pathway for muscle-specific expression in ventricular cardiac muscle cells.


Input: Mutations in either gene block some crucial late step in assembly of F1, causing the alpha and beta subunits to accumulate in mitochondria as inactive aggregates (Ackerman, S.


Input: Expense limits the use of hepatitis B vaccines, but low-dose intradermal immunization has been evaluated as a cost-saving strategy in numerous studies.


Input: Estrogen replacement therapy and risk of breast cancer: results of two meta-analyses.


Input: Switching FDC-P1/MAC cells from growth in M-CSF to GM-CSF caused the selective degradation of c-fms mRNA within 6 h after factor switching.

M-CSF

GM-CSF

c-fms mRNA


Input: There was however, no significant difference in the prevalence of chronic respiratory symptoms between animal food workers with positive and negative skin tests to house dust or to fish flour or among those with increased or normal IgE (except for dyspnea).

IgE


Input: An unexpected finding was the presence at position-403 to-385 of a putative dioxin responsive element, a sequence found to be responsible for the induction of transcription of the cytochrome P450IA1 gene (CYPIA1) and other genes involved in detoxification/activation of polycyclic aromatic hydrocarbons.

cytochrome P450IA1 gene


Input: Using bovine and murine c-myb clones, no change in the rate of c-myb gene transcription or mRNA stability was detected during the cell cycle.

bovine and murine c-myb

c-myb gene


Input: A 13 base-pair oligonucleotide spanning nucleotides + 80 to + 92 of the 5 S RNA gene retained specific and high-affinity binding, although the latter was reduced sixfold relative to longer DNA fragments.

5 S RNA gene


Input: Moreover, the reconstitution of eUSF and TFIID-depleted transcription complexes with purified protein fractions demonstrate that not only TFIID but also eUSF essentially participates in complex formation even on H5 promoter mutations lacking the TATA-box.

eUSF

TFIID

TFIID

eUSF

H5 promoter


Input: Radiolabelled palmitate was not incorporated into the mutated protein, showing that lipid modification occurs at the Cys-22 residue.


Input: 17 volunteer deaf Ss were compared with 18 volunteer hearing Ss on the Stanford Hypnotic Clinical Scale (SHCS) of Morgan and J.


Input: Mature tobacco L12 protein has 44% amino acid identity with ribosomal protein L7/L12 of Escherichia coli.

Mature tobacco L12 protein


Input: Nuclear-encoded chloroplast ribosomal protein L12 of Nicotiana tabacum: characterization of mature protein and isolation and sequence analysis of cDNA clones encoding its cytoplasmic precursor.

Nuclear-encoded chloroplast ribosomal protein L12 of Nicotiana tabacum


Input: The gene encoding IFN-gamma was previously found to contain an intronic enhancer element that was not tissue-specific in its activity, despite the restricted expression of the intact IFN-gamma-encoding gene.

IFN-gamma

IFN-gamma-encoding gene


Input: Molecular cloning of the polypeptide component of the Rel-related human p75 nucleoprotein complex has revealed its identity with the 65-kDa (p65) subunit of NF-kappa B.

Rel-related human p75 nucleoprotein complex

NF-kappa B


Input: Of the drugs orally administered, WR-168643 was the best protector with a DMF of 1. 51.


Input: Characterization of these R subunits by their 8-azido-cAMP photoaffinity labeling and immunoreactivity, as well as by a phosphorylation-dependent mobility shift on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), indicated subunit sizes of RII beta (53 kDa) greater than RII alpha dephosphoform (51 kDa) greater than RI alpha (49 kDa).

RII beta

RII alpha

RI alpha


Input: Comparison of the genomic DNA sequence with that of the four different mRNAs indicates that these transcripts are produced by alternative splicing of the murine pre-mRNA according to a cassette model.


Input: During the 1980' s, quantifications of immunoserological testings, especially C reactive protein, rheumatoid factor and antistreptolysin O, progressed rapidly.

C reactive protein

rheumatoid factor

antistreptolysin O


Input: Within the human enhancer, these two sites are located within the previously defined DNase I footprints, NFAT-1 and NFIL-2B, respectively.

DNase I footprints


Input: The cardiac myosin light chain-2 (MLC-2) gene promoter contains several positive and negative cis-acting sequences that are involved in the regulation of its expression.

cardiac myosin light chain-2


Input: Deletion mutagenesis demonstrated that these two elements are involved in the positive regulation of MLC-2 gene transcription.

MLC-2 gene


Input: Disruption mutations have been constructed in the SLK1 gene. slk1 null mutants cannot grow at 37 degrees C, but many cells can grow at 30, 24, and 17 degrees C.

SLK1 gene

slk1 null mutants


Input: Molecular and genetic analysis of the yeast early meiotic recombination genes REC102 and REC107/MER2.

yeast early meiotic recombination genes REC102


Input: Probable progressive multifocal leukoencephalopathy (PML) was diagnosed on the basis of clinical picture and magnetic resonance imaging in a 63-year-old man with a complete remission of a non-Hodgkin' s lymphoma.


Input: Proprotein processing occurs intracellularly.


Input: A 32P-labeled LAP DNA-binding and dimerization domain " zipper probe " was used to isolate a clone that encodes a new C/EBP-homologous protein: CHOP-10.

LAP

C/EBP-homologous protein


Input: Using a degenerate oligodeoxyribonucleotide (oligo) based on the N-terminal aa sequence, plus an internal oligo homologous to a conserved region within the portion of CYP1 and CYP2 that had been deleted in the genome, a CYP3-specific DNA fragment was generated by the polymerase chain reaction (PCR) using GL81 genomic DNA as a substrate.

CYP3-specific DNA fragment


Input: Stringent hybridization of EHS-1 back to primate genomic DNA indicates two distinct EHS-1 loci in normal human DNA, an identical band pattern in chimpanzee DNA, and a single locus in rhesus monkey DNA.

EHS-1 loci


Input: The level of carboxyl-terminal parathyroid hormone in the patients with thyroid carcinoma was higher than that in the patients without thyroid carcinoma (P less than 0. 05).

carboxyl-terminal parathyroid hormone


Input: The Caenorhabditis elegans vitellogenin genes are subject to sex-, stage-, and tissue-specific regulation: they are expressed solely in the adult hermaphrodite intestine.

Caenorhabditis elegans vitellogenin genes


Input: The functions of isolated portions of the insulin, IAPP, and beta GK promoters were studied by using transient expression and DNA binding assays.

insulin

IAPP

beta GK promoters


Input: The c-Ets-1 oncoprotein is a transcription activator that specifically binds to DNA.

c-Ets-1 oncoprotein


Input: Previous transactivation experiments indicated that three amino acids residing in this region, Gly, Ser and Val, appear to be critical for target-site discrimination.


Input: GR63178A is a water-soluble analogue of mitoquidone, a pentacyclic pyrroloquinone.


Input: Marker rescue analysis has localized ts8 to a 910-bp internal segment of rpoB that encodes the Rif domain.

rpoB

Rif domain


Input: This vector transfected into the yeast Saccharomyces cerevisiae directs expression of a secreted mature protein at levels up to 200 mg of LAPP/liter of culture medium.


Input: Competition analysis by gel mobility shift electrophoresis indicates that this DNA-protein interaction is novel and not related to many transcription factors previously reported.


Input: This DNA motif represents a novel protein-binding sequence.


Input: OBJECTIVE: The study was designed to investigate the frequency of alterations in serum creatinine in patients with psoriasis receiving 5 mg/kg/day of cyclosporine.


Input: Intrapocket chemotherapy in adult periodontitis using a new controlled-release insert containing ofloxacin (PT-01).


Input: Electromagnetic blood flow (BF) probe was applied on the left anterior descending artery (LAD).


Input: Hence temperature and virF are both required for the induction of the yop regulon.

virF

yop regulon


Input: Problems remain to be resolved in the area of quantitative risk assessment.


Input: The Klebsiella aerogenes gene maoA, which is involved in the synthesis of monoamine oxidase, was induced by tyramine and the related compounds, subjected to catabolite and ammonium ion repression, and cloned.

Klebsiella aerogenes gene maoA

monoamine oxidase


Input: Eight of 14 infectious or inflammatory lesions could be detected in the early scan (4-6 h p. i.).


Input: Similar observations have been made previously for other genes.


Input: Preceptorship of CNS students: an exploratory study.


Input: To determine the genetic basis for the differences between the cardiac and brain AE3 variants, we isolated and characterized the rat gene.

brain AE3 variants


Input: The 1. 7 kb cloned fragment was sequenced and shown to contain the entire fliA gene.

fliA gene


Input: Institution of both intravenous and intracisternal administration of amphotericin B and possibly concomitant intravenous administration of dexamethasone may be warranted in situations in which the association of C. immitis with CNS vasculitis or encephalitis appears likely before serologic or cultural confirmation of C. immitis infection involving the CNS is available.


Input: Lac operators were introduced into several positions within the CAB promoter and operator-free plasmid was used as control.

Lac

CAB promoter


Input: Overproduction, purification and characterization of M. HinfI methyltransferase and its deletion mutant.

M. HinfI methyltransferase


Input: Various companies produce this type of lens.


Input: From March 5 through October 26, 1991, eight persons were diagnosed with elevated blood lead levels (BLLs) at a local hospital and were reported to the notifiable disease surveillance system maintained by the Alabama Department of Public Health (ADPH).


Input: According to the changes of perfusion defects between Ex, RD and ReI images, they were classified into 3 types: Type I; perfusion defect on the RD image was identical to ReI image (75%) Type I was divided into 2 subgroups whether perfusion defect at Ex was unchanged (Ia, 42%) or improved (Ib, 33%) on the RD image.


Input: Keck, C. J.


Input: Twenty-eight (7. 0%) infants without periventricular hemorrhage were revealed as having spastic cerebral palsy by neurodevelopmental evaluation in later infancy.


Input: A possible mechanism is that elevated alveolar pressure and decreased cardiac output eliminate blood flow from corner vessels in nondependent high VA/Q regions.


Input: In both cities, HTLV-I/II prevalence increased significantly with age, and the New Orleans age-and sex-adjusted HTLV-I/II prevalence was significantly higher than that of Baltimore (P less than. 001).


Input: Hybridization data indicate that 6F6. 2 corresponds to the previously characterized m6F6 cDNA clone and that 6F6. 1 and 6F6. 3, but not 6F6. 2, are adjacent to alpha-type genes.

6F6. 2

m6F6 cDNA clone

6F6. 1

6F6. 3

6F6. 2

alpha-type genes


Input: The SEN1 gene corresponds to a 6, 336-bp open reading frame coding for a 2, 112-amino-acid protein (molecular mass, 239 kDa).

SEN1 gene


Input: Protein tyrosine kinases (PTKs) are implicated in the control of cell growth by virtue of their frequent appearance as products of retroviral oncogenes, as intracellular signal transducers, and as growth factor receptors or components thereof.

Protein tyrosine kinases

PTKs

growth factor receptors


Input: The IA4 mAb was identified among a series of antibodies raised in BALB/c mice after immunization against a HLA class I-deficient, lymphokine-activated killer (LAK)-susceptible EBV-B lymphocyte line.

IA4 mAb

HLA


Input: In a randomized double-blind cross-over study, the subjects received theophylline 5 mg. kg-1 per day with omeprazole 20 mg per day or identical placebo during two periods, each of 7 days, separated by a washout period of 7 days.


Input: Primer extension and mung bean and S1 nuclease mapping indicated multiple transcription initiation sites and were consistent with Northern analyses.

mung bean and S1 nuclease


Input: Two variant PRP-precursor alleles occur which slightly differ in the number of repeats in domain C.

PRP-precursor alleles


Input: Unlike the typical enhancer element, this region functions in an orientation-dependent manner.


Input: Allagille' s syndrome associated with antenatal ascites


Input: Sensitivity and specificity was established for the Pharmacia CAP System and the DPC AlaSTAT System by comparison with results of the skin prick test.


Input: PSI-G and PSI-K probably have evolved from a gene duplication of an ancestral gene.

PSI-G

PSI-K


Input: Site-directed mutagenesis revealed that two clusters of basic amino acids within a conserved basic region and two amphipathic helices within the adjacent HLH domain are essential for sequence-specific DNA binding and hetero-oligomerization, respectively.


Input: Dimerization of Myf-5 with the ubiquitously expressed bHLH protein E12 not only increases the affinity for DNA but also stimulates transactivation independently of DNA binding.


Input: SEA was recorded with bidirectional filters at 25-250 HZ and 40-250 Hz using Simson method.


Input: Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C.

zinc-finger transcription factor NGFI-C


Input: An experiment examined the effects of treatment with gonadotrophin releasing hormone (100 micrograms GnRH injected 24 h after progestagen sponge removal), season of treatment (autumn v. spring), the effect of supplementary feeding with lupin grain (in autumn only, from 12 days before until 8 days after sponge removal) on the time of ovulation in 182 mature Merino ewes superovulated with a combination of 400 I. U. pregnant mare serum gonadotrophin (PMSG) and 12 mg follicle stimulating hormone (FSH-P).

gonadotrophin releasing hormone

GnRH

pregnant mare serum gonadotrophin

PMSG

follicle stimulating hormone

FSH-P


Input: Drug-drug interactions are most likely to occur in patients receiving multiple medications and with drugs that have a narrow therapeutic window.


Input: Total body irradiation was delivered according to a hyperfractionated scheme of 12 fractions given three per day 5 hr apart for 4 days.


Input: A reduction in blood pressure was only observed at the end of the study, from 142 +/-17/86. 6 +/-9. 1 to 139 +/-13/82. 9 +/-8. 9 mmHg (P less than 0. 05 for DBP).


Input: A gene homologous to the Escherichia coli dnaA gene was isolated from Pseudomonas putida and its transcription was investigated in E. coli as well as in P. putida.

Escherichia coli dnaA gene


Input: STP1 is an unessential yeast gene involved in the removal of intervening sequences from some, but not all, families of intervening sequence-containing pre-tRNAs.


Input: Using these antibodies, we were able to define the conditions to completely solubilize the Cdc25 protein.

Cdc25 protein


Input: GCR1 gene function is required for high-level glycolytic gene expression in Saccharomyces cerevisiae.

GCR1 gene


Input: The decay curves of chlorophyll fluorescence showed a superposition of three exponentially decaying components with time constants of T1 = 100-200 ps, T2 = 300-500 ps and T3 = 2. 0-3. 5 ns.


Input: After tilting, systolic blood pressure fell an average of 17% in patients who cramped infrequently (p = 0. 0031) but only 10% in frequently cramping patients.


Input: Most apneic events occurred during Stages I and II, and REM, but this proportion was less during the gamma OH study (77. 9 +/-8. 9%) than during the control studies (92. 3 +/-1. 9 and 95. 9 +/-2. 2%), apneas occurring even during SWS with gamma OH. (ABSTRACT TRUNCATED AT 250 WORDS)


Input: Eight rabbits were exposed to 0. 7 +/-0. 4 mg/m3 Co2 + as CoCl2 and 1. 2 +/-0. 7 mg/m3 Cr3 + as Cr (NO3) 3 (group Co + Cr), eight to 0. 6 +/-0. 5 mg/m3 Co2 + (group Co), and eight to filtered air (control group), for 4 months, 5 days/week, and 6 hr/day.


Input: 16 women were treated with methadone to prevent withdrawal symptoms.


Input: Disruption demonstrates that CDC14 is an essential gene.


Input: Coronary flow was reduced by 10% in the phosphocreatine and by 18% in the control group.


Input: The 60A transcripts and protein are first detected at the onset of gastrulation, primarily in the mesoderm of the extending germ band.

60A transcripts


Input: Influence of neural regulation on anti-arrhythmic effects of GABA in rats


Input: Recent investigations have detailed a selective dye release technique in which a pulse of laser light induces the release of a fluorescent dye from temperature-sensitive liposomes circulating in the retinal vasculature.


Input: And the natural barriers?


Input: Three pyridoxine derivatives have been isolated from the fresh stem bark of Albizzia julibrissin DURAZZ..


Input: The coating materials were poloxamine 904, poloxamine 908, poloxamine 1508, poloxamer 338, and Brij 35.


Input: The eating and drinking patterns of pygmy goats fed ad lib and kept on a 12 h light/12 h dark cycle were recorded and analyzed.


Input: The present study highlights the improvement in sputum amoxycillin (amoxy) levels when a combination tablet, amoxy 500 mg plus bromhexeine 8 mg, is administered as compared to plain amoxy 500 mg.


Input: His HC II activity and antigen levels were 49% and 50%, respectively, and his daughter also showed similar low levels.

HC II


Input: Argatroban may be more effective under low HC II conditions because of its potent inhibition of thrombin activity at sites of vascular wall damage.

HC II

thrombin


Input: Because the adrenergic nervous system influences cardiac arrhythmias and myocardial infarction can directly affect sympathetic innervation in the heart, we investigated the role of the sympathetic nervous system on reentry in the canine heart 4 days after infarction.


Input: Furthermore, no transcripts of the same size and having the same developmental profile as those generated by the wild-type E10 fragment were identified by probes covering the remainder of the cloned region.

wild-type E10 fragment


Input: Intravenous amine pressor tests in healthy volunteers.


Input: The mean minimum steady-state concentration after the oral regimen (23 micrograms. l-1) was 78% of that after the intramuscular regime (29 micrograms. l-1).


Input: In an ongoing study the performance of the SMSP is being compared with that of the Mini Speech Processor (MSP).


Input: These mutant proteins retained the ability to competitively inhibit kappa B-mediated transcriptional activation of the human immunodeficiency virus long terminal repeat but failed to efficiently transform chicken lymphoid cells both in vitro and in vivo.

kappa B

human immunodeficiency virus long terminal repeat


Input: The sequence-specific interaction of nuclear factor HiNF-D with this key proximal promoter element of the H4-FO108 gene is cell cycle regulated in normal diploid cells (J.

nuclear factor HiNF-D

H4-FO108 gene


Input: In conclusion, to study and overcome TI region-based expression problems it is worthwhile to start out with a versatile vector containing exhaustive mutations in the periShine-Dalgarno sequences; as a rule the coding MTI subregion can be kept unchanged.


Input: Four of these five subjects also performed mixed sequences under conditional control of the words (e. g., A1----B2----A3----B4----A5 and its reversal), verifying that the stimuli which occupied the same position in each sequence were members of the same class.


Input: While blood pressure and noradrenergic activity, assessed as changes in the plasma levels and urinary excretion of norepinephrine, remained unaffected in the Pl group, a significant drop in the supine systolic and diastolic blood pressures, as well as in the resting venous norepinephrine level and in urinary norepinephrine excretion was found after the first month of dF administration.


Input: Wild-type protein bound azido-ATP well, but mutants with substitutions in the consensus amino acids were unable to bind azido-ATP.


Input: Therefore, with a biopsy from the stoma site there is a risk of missing early rejection.


Input: Whole blood serotonin levels were investigated in a control group (n = 35) and in a group of chronic renal failure patients (n = 127) on various treatment regimen i. e. conservative treatment (n = 39), maintenance haemodialysis (n = 35) and after renal transplantation (n = 53).


Input: Tissues and exudates contain sufficient thymidine for growth of anaerobic bacteria in the presence of inhibitory levels of trimethoprim-sulfamethoxazole.


Input: The homologies between RAD16, RAD54 and SNF2 are also shared by several additional, recently isolated yeast and Drosophila genes.


Input: But the application solutions of instrument disinfectants should not be used longer than one day.


Input: In the Rett syndrome we, therefore, suspect there are disturbances in the brain stem functions especially in the ascending reticular activating system which is related to elevation of the conscious level.


Input: In a similar experiment, simultaneous nitrofurazone administration and S. enteritidis challenge resulted in no significant differences in S. enteritidis isolation frequency.


Input: In agreement with this southern blotting of mouse DNA with SmN probes reveals bands, additional to those derived from the pseudogene, which are characteristic of an intron-containing SmN gene.

SmN

SmN gene


Input: Two cDNAs encoding casein kinase-1 have been isolated from a yeast cDNA library and termed CKI1 and CKI2.

casein kinase-1


Input: Incidence rate ranging between 122/100, 000/year and 190/100, 000/year were found (minimum, estimated and raw datasets).


Input: The observed sequence variation disrupts the first ORF in many Y' s while most of the second ORF including the putative helicase region is unaffected.

Y

helicase region


Input: The final screening yielded a clone containing a 2 kilobase (kb) insert.


Input: Lesions were made by pressure injection of kainic acid into the SOC through a stereotaxically positioned glass micropipette.


Input: A 38-bp poly (dA-dT) region was found to be a positive regulator of Act1 promoter activity.

Act1 promoter


Input: We identified a protein, termed NFIL-1 beta A (NF beta A), that binds to a highly conserved 12-bp DNA sequence (-49 to-38) located upstream of the TATA box motif in both the human and murine IL-1 beta genes.

NFIL-1 beta A

NF beta A

human and murine IL-1 beta genes


Input: We tried amphotericin B (AmB), and remission of the tumor was obtained.


Input: Cutis aplasia.


Input: The DRF-2 nuclear protein has characteristics similar to those of the muscle-specific regulatory factor, MEF-2 (Buskin and Hauschka 1989; Gossett et al., 1989).

DRF-2 nuclear protein


Input: From the 15-kb clone a 4-kb EcoRI fragment containing the first two exons and 2. 6 kb of the 5' flanking region of the opn gene was sequenced, and the transcriptional start site determined by primer extension analysis and S1 nuclease mapping.

4-kb EcoRI fragment

opn gene

S1 nuclease


Input: Cardiovascular risk factors were measured by standardized techniques.


Input: Production costs included feed, non-feed operating, fixed, and replacement stock costs.


Input: We report a patient developing factor VII inhibitor possibly as a reaction to penicillin administration; it gave rise to fatal haemorrhage.

factor VII inhibitor


Input: Account was taken of noncellular and nonhuman elements in the smears; they included mucus, Charcot-Layden crystals, pollen grains, vegetal fragments and fungi.


Input: The results indicate that the carbon-perfused areas and MBF in the liver, renal cortex, spleen, and small intestinal serosa (only MBF) increased significantly 5 h after CLP.


Input: Lewis, N.


Input: This accurate and rapid method makes the MLPA test logistically feasible for large-scale screening.


Input: The modalities for using reference values for individual subjects as well as for groups are then discussed and the main points of research which must be faced in the near future regarding reference values are highlighted.


Input: The clinical application of the antibody-targeted Phthalocyanine was performed in 3 patients suffering from an advanced ovarian carcinoma (FIGO III).


Input: We found that lung cancer tissues of positive 67Ga scan expressed TFR, but those of a negative scan did not.

TFR


Input: This open reading frame was confirmed the correct one by direct amino-terminal sequence analysis of the overproduced msgB gene product.

msgB gene product


Input: In this study, we purified and characterized the recombinant furin from the conditioned medium of these cells.

recombinant furin


Input: The virus encodes a 40-kDa protein, tax, that is important for the immortalization of T cells.

tax


Input: However, butyrate was at least 2-fold more effective in stimulating CAT activity of fusion genes containing upstream sequences (-834 to-576) than those containing proximal sequences (-456 to-172), suggesting two regions in the PSG1-I gene that mediate the butyrate response.

CAT

PSG1-I gene


Input: An examination of the role of the carboxyl terminus in regulating NGFI-B transcriptional activity revealed that, in accordance with other nuclear receptors, mutants lacking portions of the carboxyl terminus had greatly decreased activity.

NGFI-B


Input: Altogether these results indicate that the Syn 5 locus segregates from the gene specifying gH, to a region encompassing portions of the TK and UL 24 genes, and that the syn mutation does not affect the expression or activity of TK.

Syn 5 locus

gH

TK

UL 24 genes

syn mutation

TK


Input: Nucleoprotein (N) expressed by both recombinant vaccinia virus and TGEV had a relative molecular mass (Mr) of 47, 000 and was susceptible to degradation at the C-terminus yielding discrete breakdown products.


Input: Recently, the 3. 6-kb full-length alpha-GalNAc cDNA sequence was isolated and found to have remarkable nucleotide and predicted amino acid homology (55. 8 and 46. 9%, respectively) with the human alpha-galactosidase A (alpha-Gal A) cDNA.

3. 6-kb full-length alpha-GalNAc cDNA sequence

human alpha-galactosidase A

alpha-Gal A


Input: The reason that nitrous oxide does not produce hydroxyl radicals readily might be that the one-electron reduction proceeds through an N2O-intermediate which is energetically very unfavourable: EO (N2O/N2O-) =-1. 1 V.


Input: All mutant JCV T antigens bound to JCV and SV40 origins of DNA replication.

mutant JCV T antigens


Input: Since each transcript appears to encode the same protein, this complexity may reflect the need for lineage-specific or differentiation-dependent control of expression.


Input: In patients with limited disease, the survival in the alternating arm was significantly superior to the survival in the CAV arm (P =. 014) or the survival in the PE arm (P =. 023).


Input: We identify the " M region " of the muscle-specific Xenopus cardiac actin gene promoter from-282 to-348 as necessary for the embryonic expression of a cardiac actin-beta-globin reporter gene injected into fertilized eggs.

muscle-specific Xenopus cardiac actin gene promoter

actin

beta-globin


Input: In addition to the previously identified and characterized attenuator 1 situated 93 nucleotides downstream from the major late transcription start site, a second attenuator, attenuator 2, situated 55 nucleotides downstream from it, has been identified.

attenuator 1

attenuator 2


Input: EBNA-2 and the cis-acting CD23 element increased TK-promoted mRNA and did not alter the herpes simplex virus TK promoter transcription start site.

CD23 element

TK

herpes simplex virus TK promoter transcription start site


Input: These experiments delineate a 186-bp, EBNA-2-responsive cell DNA fragment and provide firm evidence that EBNA-2 transactivates transcription of cell genes.


Input: Plasma vitamin E, total lipids and myeloperoxidase levels during spinal surgery.

myeloperoxidase


Input: Transfecting the cloned bovine PBR/IBP cDNA into COS-7 cells resulted in an 11-fold increase in the density of high affinity [3H] PK 11195 binding sites which had only low affinity for Ro5-4864.

PBR

IBP


Input: The initial phase of increased vascular permeability in the peritoneal cavity and LTB4 production was dose dependently inhibited by the 5-LO inhibitors phenidone, BW A4C, A63162, and ICI 207 968 but not by dexamethasone or colchicine.


Input: Discrepant results with a latex agglutination test in the assessment of cytomegalovirus antibody status of cardiac transplant donors.


Input: Each mRNA contained five or six internal uridine residues, which were transcribed using a mixture of UTP and thio-UTP.


Input: We have isolated and sequenced two overlapping cDNA fragments which could encode the complete amino acid sequence of rat testis fructose-6-phosphate, 2-kinase: fructose-2, 6-bisphosphatase.

rat testis fructose-6-phosphate, 2-kinase

fructose-2, 6-bisphosphatase


Input: We have identified SWI5' s nuclear localization signal (NLS) and show that it can confer cell cycle-dependent nuclear entry to a heterologous protein.


Input: In contrast to behavioral deviation (the avoidance conditioning lost), the haloperidol intrastriatal microinjections did not affect the DA synaptic level in rostral neostriatum.


Input: In similar transient transfection experiments in HeLa cells, overexpression of the wt human retinoblastoma susceptibility gene product, RB, was found to repress the serum-induced IL-6 (-225 to + 13), c-fos (-711 to + 42), and beta-actin (-3400 to + 912) promoters but not the PRV-induced IL-6 (-110 to + 13) or the serum-induced MHC (-528 to-38) promoters.

wt human retinoblastoma susceptibility gene product

RB

c-fos

beta-actin

MHC


Input: This repression was mediated through binding to the E2 DNA-binding site immediately upstream of the P105 promoter TATA box and could be abrogated by preincubation of the HPV-18 P105 promoter template with the nuclear extract allowing the formation of the preinitiation complex.

E2 DNA-binding site

HPV-18 P105 promoter


Input: We did not detect p50 in association with native glucocorticoid receptor in L cells or with the overexpressed glucocorticoid receptor in Chinese hamster ovary cells.

native glucocorticoid receptor

glucocorticoid receptor


Input: Two putative 12-O-tetradecanoyl-phorbol-13-acetate (TPA) response elements, that might serve as binding sites for the transcription factor AP-1 and a consensus sequence of a transforming growth factor beta 1 (TGF-beta 1) inhibitory element were found in the promoter region.

transcription factor AP-1

transforming growth factor beta 1

TGF-beta 1


Input: TPA and TGF-beta 1 did not markedly affect the activities of the 72-kDa enzyme.

TGF-beta 1


Input: They were almost regularly excited by pressure to the ipsilateral cornea or to both corneas at a strength well above the human corneal pain threshold.


Input: Feed intake was not affected by dietary KCl or NaHCO3 supplementation, but average daily gain increased with increased K and tended to be reduced by dietary NaHCO3.


Input: Extraction procedure for the measurement of butyltin compounds in biological tissues using toluene, HBr, and tropolone.


Input: In this study, we have cloned a region that complements the exoenzyme S-deficient phenotype of strain 388 exs1:: Tn1, a chromosomal Tn1 insertional mutation.

exoenzyme S

chromosomal Tn1 insertional mutation


Input: Alignment of the amino acid sequences surrounding Tyr-766 with corresponding regions of other FGFRs revealed conserved tyrosine residues in all known members of the FGFR family.

FGFRs

FGFR family


Input: The transcription initiation site was determined to occur 66 bp upstream of the initiating Met.


Input: All anti-I and anti-i CA were shown to express VH4 heavy chains, and 14 of 17 CA expressed a previously described VH4 second hypervariable region determinant, termed VH4-HV2a.

anti-I

anti-i CA

VH4 heavy chains

CA


Input: Intron K1 cox1. 2 is not found in S. cerevisiae and appears at an unique location in K. lactis.

K1 cox1. 2


Input: We have determined that the mutants define two complementation groups, designated cgs1 + and cgs2 + (continues to grow in stationary).

cgs1 +

cgs2 +


Input: The results of induced coexpression were also supported by rapid generation of FeLV recombinants when FeLV-C was used to infect the feline 3201B cell line that constitutively expresses high levels of endogenous FeLV-specific mRNAs.


Input: Recombination between feline leukemia virus subgroup B or C and endogenous env elements alters the in vitro biological activities of the viruses.

env


Input: The nucleotide sequences at the 5' and 3' ends of these introns are characteristic of spliced transcripts from eukaryotic protein-encoding genes, with one significant difference; i. e., the 5' end of the LAT intron is GC instead of the consensus sequence GT.

LAT intron


Input: At 1, 5, and 9 months after initial isolation of C. kutscheri from the oral cavity, hamsters were euthanatized, and attempts were made to culture C. kutscheri from 13 additional sites.


Input: The strategy has been used to determine 2. 6 kilobases of nucleotide sequence in the Saccharomyces cerevisiae ADE 1 locus.

Saccharomyces cerevisiae ADE 1 locus


Input: Two independent promoters as well as 5' untranslated regions regulate Dd ras expression in Dictyostelium.

Dd ras


Input: The results suggested that, depending upon the cell type, gene cotransfer using aminoglycoside resistance as a selectable marker may seriously perturb important cellular control mechanisms such as the PKC pathway leading to activation of gene expression.

PKC


Input: Therefore, the strD and strE genes could serve as universal probes indicative of the presence of biosynthetic capacity for 6-deoxyhexose moieties.

strD

strE genes


Input: The two genes code for polypeptides of 420 amino acids (M. HgiCI) and 345 amino acids (R. HgiCI).

polypeptides of 420 amino acids (M. HgiCI)

345 amino acids (R. HgiCI)


Input: Expression of the wt1 gene via transient transfection in COS-1 cells revealed a 52 kDa protein which was immunoprecipitated by both the N-terminal-and C-terminal-specific antisera.

wt1 gene


Input: The factor which binds to the TR promoter co-sedimented with SV40 chromosomes extracted late in infection.

TR promoter


Input: Temafloxacin 400 mg b. i. d. administered orally for 28 days represents a safe and effective treatment for chronic bacterial prostatitis.


Input: Its neuromuscular effects are similar to a single ED90 dose of vecuronium.


Input: The patient with a prolonged fever caused by dissecting aneurysm of the aorta in whom pleuropneumonia masked the real diseases has been presented.


Input: The resulting clone pKB11, which has a 1369-base pair (bp) cDNA insert, overlapping pCAD142 by 781 bp, was identified by hybridization methods and sequence analysis and found to contain the entire cDNA sequence for the amino end of the CAD polypeptide.

CAD polypeptide


Input: This conclusion was confirmed by Northern blotting analysis of the 5'-flanking region of CAD gene.

CAD gene


Input: We report the isolation of genomic and cDNA clones of the light-independent Sn: bol3 allele.

Sn: bol3 allele


Input: Its clearance has been found to be decreased (typically by around 25%, but often by far more) by erythromycin, troleandomycin (triacetyloleandomycin), roxithromycin, enoxacin, ciprofloxacin, pefloxacin, norfloxacin, ofloxacin, fluoroquinolone T-3262, pipemidic acid, cimetidine, etintidine, propranolol, verapamil, diltiazem, nifedipine, furosemide (frusemide), at least some anovulent agents, viloxazine, allopurinol, ticlopidine, idrocilamide, thiabendazole, disulfiram, influenza-and BCG-vaccination, interferon, and caffeine (half-life increase).

interferon


Input: We enrolled 253 HIV-antibody positive heroin addicts without HIV-related disease (n = 81) or with persistent generalized lymphadenopathy (n = 172) in a prospective study to evaluate clinical progression to AIDS related complex (ARC) or AIDS and to identify factors of possible prognostic relevance.

HIV-antibody


Input: No homology was found between RNA14 and RNA15 or between RNA14 and other proteins contained in data banks.


Input: Mutations in the yeast RNA14 and RNA15 genes result in an abnormal mRNA decay rate; sequence analysis reveals an RNA-binding domain in the RNA15 protein.

yeast RNA14

RNA15 genes

RNA15 protein


Input: Myocardial infarction in patients with previous bypass surgery.


Input: The most striking difference in the birch NAD (P) H-NR sequence in comparison to NADH-NR sequences was found at the putative pyridine nucleotide binding site.

birch NAD (P) H-NR sequence

NADH-NR sequences


Input: A single amino acid difference in the C-terminal region influences dominant negative activity and receptor dimer formation.


Input: The 95% confidence values (2SD) for the change in Ros required to exclude natural variability were 0. 39, 0. 50 and 0. 53 cmH2O l-1 s, respectively.


Input: Among 953 infants in 22 neonatal care units studied, 23% (median value, range 0-78) were found to be faecally colonized with one of 21 distinct nosocomial strains of Escherichia coli, Klebsiella or Enterobacter spp.


Input: Biochemical studies revealed the expected loss of ChAT activity in the dorsal and ventral hippocampi of lesioned animals along with elevated levels of norepinephrine (NE) in the dorsal hippocampus of MS/HSI animals. (ABSTRACT TRUNCATED AT 250 WORDS)

ChAT


Input: The localization of this proteoglycan locus in the human genome and the availability of new RFLPs provide the tools for future studies of human diseases where the HSPG2 proteoglycan gene is suspected to be involved.

HSPG2 proteoglycan gene


Input: After 2 min of dobutamine injection, or after 20 min of pimobendan injection, the myocardium was removed, and used for determination of the tissue levels of metabolites of energy and carbohydrate metabolism.


Input: During coronary stenosis, on the contrary, intracoronary procaterol at the same dose significantly deteriorated regional myocardial dysfunction without changing LCX flow, global hemodynamics and cardiac lactate metabolism.


Input: Here we present evidence that major IE proteins IE86, IE72, and IE55 are capable of trans-activating the HIV LTR in a T-cell line, HUT-78.

major IE proteins IE86

HIV LTR


Input: In a country where general HIV prevalence is low, the strategy is cost-effective for location and counselling of unknowingly seropositive individuals.


Input: The cis-acting element mediating glucocorticoid inducibility of the chicken glutamine synthetase gene has been identified.

chicken glutamine synthetase gene


Input: However, the increase in biliary excretion did not compensate for the reduced elimination of bretylium and hexylsalicylic acid via the kidney.


Input: Diagnostic value of cerebrospinal fluid immunoglobulin G (IgG) in pediatric neurological diseases.

cerebrospinal fluid immunoglobulin G

IgG


Input: Expression of six genes, ipaB, ipaC, invE, invG, invJ, and invK, was apparently regulated by the positive regulator virF.

ipaB

ipaC

invE

invG

invJ

invK

virF


Input: Inducible VT was suppressed entirely in one patient.


Input: The presence of the corresponding mature mRNA transcripts (3. 2-3. 5 kilobase pairs (kb] in human fibroblasts was shown by Northern blot hybridization, S1 nuclease protection assay, and the polymerase chain reaction.

S1 nuclease


Input: Approximately 50% of the ribosomal DNA (rDNA) units of Drosophila melanogaster are inactivated by two different 28 S RNA ribosomal gene insertions (type I and type II).

28 S RNA ribosomal gene


Input: Gap b3 consists of two polypeptide chains (Mr = 110, 000 and 30, 000), which seem to be proteolytic cleavage products connected by disulfide bonds from a precursor protein.

Gap b3


Input: However, the rtFc gamma R alpha cDNA clone is complementary to at least two different-sized mRNAs expressed by CRNK-16 cells, contrasting the single Fc gamma R-related mRNA species expressed by human and mouse natural killer cells.

rtFc gamma R alpha cDNA

Fc gamma R-related mRNA


Input: Both genes comprise three exons, two introns and an unusually long 3'-untranslated region (3. 2 kilobase pairs), specificying a mRNA of approximately 4. 1 kilobases.


Input: This exon, here named exon 0, contained the entire 5' untranslated region and the N-terminal signal sequence of the polypeptide.


Input: Treatment of human myeloid cell lines HL-60 and U937 with phorbol 12-myristate 13-acetate (PMA) increased within 2 h cellular levels of the RNA hybridizable to LD78 cDNA.

LD78 cDNA


Input: A new, flexible fiberoptic ventriculoscope for observation of the ventricles and major cisterns is reported.


Input: Isopenicillin N isomerase (epimerase) has been purified from Streptomyces clavuligerus, and the amino acid sequence of the N-terminus has been determined.

Isopenicillin N isomerase

epimerase


Input: Serum IgG was initially elevated in 6 patients.

IgG


Input: The patient initially attained complete remission (CR1) with conventional chemotherapy and then relapsed 14 months later.


Input: 157 +/-16 mg/dl; NS), glucose levels, and basal (17 +/-4 vs.


Input: Platelet aggregation and metabolic control are not affected by calcium antagonist treatment in type II diabetes mellitus.


Input: Wnt-1 (int-1) is a cellular oncogene often activated by insertion of proviral DNA of the mouse mammary tumor virus.


Input: Induction of Jurkat leukemic T cells with phorbol 12-myristate 13-acetate and ionomycin did not affect the level of FKBP mRNA.

FKBP mRNA


Input: GLUT5 mRNA is expressed at highest levels in small intestine and at much lower levels in kidney, skeletal muscle, and adipose tissue.

GLUT5 mRNA


Input: e.


Input: We speculate that these tumors may represent congenital hamartomatous growths.


Input: Identification and characterization of the promoter for the cytotactin gene.

cytotactin gene


Input: (1988) J.


Input: These results strongly suggested that similar, if not identical, the CArG box binding proteins interact with the functionally different promoter element in the VLC1, cardiac alpha-actin, and c-fos genes.

CArG box binding proteins

cardiac alpha-actin

c-fos genes


Input: Polyadenylation of B4 RNA, which occurs very early during maturation, is limited to 150 residues, and it is this number that is required for polysomal recruitment.

B4 RNA


Input: Co-existence of these regulatory elements with other elements, such as the AP-2 element or CCAAT box, was also found.

AP-2 element


Input: Recently, studies of agents that disrupt collagen synthesis and deposition have yielded several new angiogenesis inhibitors.

collagen


Input: Since the 5'-flanking region of this gene is likely involved in hormonal regulation of its expression, we have isolated and partially characterized an avian fatty acid synthase gene.

fatty acid synthase


Input: A new set of cDNA clones spanning approximately 3. 2 kb was isolated from a lambda-ZAP goose liver cDNA library using the 5'-most exon-containing fragment of the 5'-most genomic DNA clone.


Input: Northern blotting analysis indicates that expression of the genes corresponding to these clones is confined to pollen tissue.


Input: Whereas cDNA hybridization to genomic DNA blots indicated a small subfamily of G0S19 genes, simple patterns of bands indicated that most cDNAs, including G0S30 cDNA, corresponded to single-copy genes.

G0S19 genes

G0S30 cDNA


Input: Lymphoproliferative disorders arising under immunosuppression with FK 506: initial observations in a large transplant population.


Input: The Drosophila suppressor of sable gene encodes a polypeptide with regions similar to those of RNA-binding proteins.

Drosophila suppressor of sable gene


Input: 2: 121-133, 1988).


Input: Using avidin-biotin complex DNA binding assays, a series of overlapping alpha promoter DNA sequences between-170 to 29 basepairs were tested, but each failed to bind GR, whereas a control GRE avidly bound receptor.

avidin-biotin

alpha promoter DNA sequences

GR


Input: Sequence determination of isolated peptides suggested that Asn120 is glycosylated, Asn65 and Asn109 glycosylated in some molecules but not in others, and Asn72 not glycosylated.


Input: The DNA sequence conferring AP-1 activity was located in the proximal promoter region.


Input: The murine mutation dominant white spotting (W) is in the proto-oncogene, c-kit.

murine mutation dominant white spotting

W

c-kit


Input: The proteins differ in the presence or absence of a 21-amino-acid sequence located 24 amino acids C terminal of the translational initiation codon.


Input: Our results also indicate the existence of sequences downstream of-0. 11 kb which can influence the pattern of tissue-specific expression of the HLA-B7 gene and the ability of this gene to respond to gamma interferon.

HLA-B7 gene

gamma interferon


Input: The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110.

SH3 domains


Input: These clones overlapped and contained the structural gene encoding the complete C5 alpha-chain and 90% of the beta-chain.

C5 alpha-chain


Input: The C5 alpha-chain was encoded by 49 kilobases containing 26 exons; the beta-chain was encoded by 29 kilobases containing 16 exons.

C5 alpha-chain


Input: Heterozygous mutation in the G + 5 position of intron 33 of the pro-alpha 2 (I) gene (COL1A2) that causes aberrant RNA splicing and lethal osteogenesis imperfecta.

pro-alpha 2 (I) gene


Input: The nucleotide sequences of these genes differ at only nine positions, resulting in three amino acid differences.


Input: The protein predicted by the sequence of the human pim-1 proto-oncogene shares extensive homology with known serine/threonine protein kinases, and yet the human Pim-1 enzyme has previously been reported to exhibit protein tyrosine kinase activity both in vitro and in vivo.

human pim-1 proto-oncogene

serine/threonine protein kinases

human Pim-1 enzyme

protein tyrosine kinase


Input: A full-length human pim-1 cDNA was subcloned into the bacterial vector pGEX-2T and the Pim-1 protein expressed as a fusion product with bacterial glutathione S-transferase (GST).

full-length human pim-1 cDNA

Pim-1 protein

bacterial glutathione S-transferase

GST


Input: The 10 kDa polypeptide was phosphorylated in vitro by incubating wheat etioplast membranes with [gamma 32P] ATP.


Input: Homology with the human protein is only 34% in the tandem repeat domain, mainly showing conservation of serines and threonines, presumed sites of O-linked carbohydrate attachment.


Input: In addition to targeting partially assembled Ti alpha-beta CD3 gamma delta epsilon TCR complexes to the cell surface, CD3 zeta appears to be essential for interleukin-2 production after TCR stimulation with antigen/major histocompatibility complex.

Ti alpha-beta CD3 gamma delta epsilon TCR complexes

CD3 zeta

TCR

antigen/major histocompatibility complex


Input: When desipramine was injected 16 hrs after fluoxetine injection, brain levels of desipramine were no longer elevated.


Input: Opposite effects of CYP1 are observed in aerobic, heme-sufficient cells.


Input: A segmental analysis of the key regions of HLA-DR1 that control T cell allorecognition was performed by using a series of transfected cell lines expressing the products of recombinant DRB/H-2Eb genes, paired with either DR alpha or H-2E alpha.

DRB

DR alpha

H-2E alpha


Input: We characterized cDNA clones specific for the extracellular matrix glycoprotein undulin.

undulin


Input: The alpha inhibin promoter containing a mutated CRE was not regulated by forskolin in granulosa cells and did not bind the CREB protein.

alpha inhibin promoter

CREB protein


Input: Regulation of the alpha inhibin gene by cyclic adenosine 3', 5'-monophosphate after transfection into rat granulosa cells.

alpha inhibin gene


Input: Comparison of the nucleotide sequences between the human and bovine DNA showed that the sequence similarity extended 2400 bp downstream from the coding region.


Input: In patients with osteomyelitis and joint empyema (n = 48) PMN elastase had a sensitivity of 77%, which was only exceeded by that of the unspecific erythrocyte sedimentation rate (sensitivity 89%).

PMN elastase


Input: These results indicate that the sulfhydryl group of certain angiotensin converting enzyme inhibitors can potentiate their effect on the endogenous nitrovasodilator EDRF.

angiotensin converting enzyme

EDRF


Input: Pharmacokinetics of FK 506 in transplant patients.


Input: A second even more significant match to this E. coli region was found in the retroviral ribonuclease H (RNase H) domain, and corresponds precisely to a region that has been aligned by previous investigators with the E. coli RNase H, suggesting that Pol I helices O and P are homologous to helices A and D of the RNase H crystal structure, respectively.

retroviral ribonuclease H

RNase H

E. coli RNase H

Pol I

RNase H


Input: Analysis of the deduced amino acid sequence suggests that CHIP28 protein contains six bilayer-spanning domains, two exofacial potential N-glycosylation sites, and intracellular N and C termini.

CHIP28 protein


Input: The qualitative concentrations of HCG had a sensitivity of 37. 5% and a specificity of 100%.

HCG


Input: The reduced rate of F absorption and slower rise in plasma F concentration accompanying delayed gastric emptying indicate that passage of F into the small intestine is the major factor in rapid F absorption.


Input: The activity of serum lipase and amylase distinctly increased at 3 h and went up to the maximum at 12 h after injection of Na-Tc.

serum lipase

amylase


Input: They were checked for anti-HCV (anti-C100-3) with HCV EIA kit (Abbott Lab., North Chicago, IL).

anti-HCV


Input: Diltiazem resulted in a significant increase in epicardial diameter (+ 10%; p = 0. 001) and in coronary blood flow (CBF) (+ 30%; p = 0. 0001).


Input: The first transfusion resulted in a platelet increment to 32 Gpt/l (CCI 11).


Input: These risk factors can be divided into 2 groups: local vessel wall-related factors, and local (focal action) systemic factors.


Input: Epidemiology and prevention of hospital infections in the Local Health Unit of Sassari: profile of bacterial resistance and antimicrobial agents of large usage.


Input: PRDII-BF1-derived cDNAs did not result in stimulation of either basal or tat-induced activated gene expression.

PRDII-BF1-derived cDNAs

tat


Input: Vaccinia virus (VV) is a potent immunogen, but the nature of VV proteins involved in the activation of the immune response of the host is not yet known.


Input: Max: functional domains and interaction with c-Myc.

Max

c-Myc


Input: 86: 3199-3203) or G1 to S phase (Reilly, C.


Input: Substitutions introduced at bases surrounding the ICR2 motif yielded levels of pRNA replication that differed, depending on the maintenance of a putative 5' stem-loop structure in the positive strand of the viral genome.

ICR2 motif


Input: Zn (II) coordination domain mutants of T4 gene 32 protein.

gene 32


Input: Zn (II) coordination domain mutants of T4 gene 32 protein.

T4 gene 32 protein


Input: The tissue specificity of gene expression was identical to that described previously for the CaMV 35S domain B enhancer element.

CaMV 35S domain B enhancer element


Input: The pathophysiology and clinical management of acute brain injury in infancy and childhood are presented using acute traumatic brain injury as a model.


Input: Transcripts from a second POU-domain gene, Oct-25, were present at low levels in oocytes and early embryos and were dramatically upregulated during early gastrulation.

POU-domain gene


Input: The genome of Thogoto virus comprises six segments of single-stranded, negative sense RNA.


Input: These tumors were classified into three broad groups: I, cystadenoma; II, cystadenocarcinoma; and III, adenocarcinoma with mucin production or an associated cyst.

mucin


Input: Immunostaining of cells transfected with these constructs revealed that both the myristoylated and nonmyristoylated mutants were localized in nuclei, whereas wild-type PKC alpha was primarily cytoplasmic and perinuclear.

wild-type PKC alpha


Input: We have partially sequenced the RAP74 protein from purified HeLa cells, cloned its complementary DNA and shown that its translation product can interact with RAP30 in vitro as well as in vivo.

RAP74 protein


Input: Effects of thromboxane synthetase inhibition on postburn mesenteric vascular resistance and the rate of bacterial translocation in a chronic porcine model.

thromboxane synthetase


Input: The primary pancreatic insult seemed to be unaffected by the treatment, because neither the rise in plasma lipase nor the development of ascites or the extension of the pancreatic necrosis were diminished.

plasma lipase


Input: The size of the mutant molecule corresponds to the unprocessed cytoplasmic precursor (pre-super-pro-PrB), as detected in sec61 mutants, when translocation into the endoplasmic reticulum is blocked.

pre-super-pro-PrB

sec61 mutants


Input: Thus, the active-site mutation prevents the wild-type processing of the N-glycosylated 73-kDa precursor of PrB to the 41. 5 kDa pro-PrB in the endoplasmic reticulum.

PrB

41. 5 kDa pro-PrB


Input: The predicted amino acid sequence exhibited 70% identity to that of Bacillus stearothermophilus TyrTS and 55% identity to that of E. coli TyrTS, while identity to a second cryptic B. subtilis TyrTS gene, designated tyrZ, was only 27%.

Bacillus stearothermophilus TyrTS

E. coli TyrTS

B. subtilis TyrTS gene

tyrZ


Input: Heat-inducible CAT activity was detectable when additional sequences from the native promoter containing three CCAAT boxes and a single HSE were present in the constructions.

CAT


Input: SETTING--Women, Infants, and Children clinics in Minneapolis, Minn.


Input: BACKGROUND: The effectiveness of monoamine oxidase inhibitors (MAOIs) in tricyclic resistant depression has received surprisingly little systematic study.

monoamine oxidase


Input: The upstream delta-alpha breakpoint is flanked by the direct repeats of the acceptor splice site, whereas the down-stream alpha-delta breakpoint is located in the adjacent intron.


Input: Patients with moderate PDDAT were impaired on all serial positions for both spatial order and spatial recognition memory.


Input: Bone and bones.


Input: Management often involves beta-and calcium channel blocking drugs or type IC antiarrhythmic drugs.


Input: To overcome this problem, we have overexpressed Kex2p using the baculovirus/insect cell expression system.


Input: J.


Input: The major 49-kDa core protein in the liver HSPG preparation was found to be reactive to an antibody that specifically recognizes the cytoplasmic domain of fibroglycan.

major 49-kDa core protein

HSPG

fibroglycan


Input: While no obvious transmembrane regions were identified, several short hydrophobic amino acid stretches were found to be localized in and around the Pro II region, and these may be responsible for attachment of precursors to membranes.


Input: Toxicity was mild, mainly consisting of emesis (81% of the patients; 66% of the courses), leukopenia of World Health Organization (WHO) grade 1 to 2 (47% of the patients; 18% of the courses), and thrombocytopenia (12% of the patients; 3% of the courses).


Input: This study confirms, although individual reaction is remarkably different, transportation as a potent stressor for Beagle dogs.


Input: RESULTS: Plasma AVP responses to osmotic stimulation, and non-osmotic inhibition by drinking, were normal in patients with compulsive water drinking.

Plasma AVP


Input: The fragments of each region were amplified by polymerase chain reaction and analyzed by gel electrophoresis to detect single-strand conformation polymorphism.


Input: The csbA fusion was maximally expressed during early stationary phase in cells grown in Luria broth containing 5% glucose and 0. 2% glutamine.

csbA fusion


Input: The constraints of primase recognition sequences, nucleotide substrate requirements, and the effects of additional proteins on oligoribonucleotide synthesis by the 63-kDa gene 4 protein have been examined using templates of defined sequence.

primase recognition sequences

63-kDa gene 4 protein


Input: Thrombolytic therapy in spontaneous coronary artery dissection.