Input: CASE REPORT: Referred because of a right corneal perforation with cellular reaction in anterior chamber, a patient was sutured and treated with a single intravitreal injection of 0. 2 ml (1 mg) Amikacin and 0. 2 ml (1 mg) Vancomycin.


Input: The P-wr and P-rr cDNA sequences are very similar in their 5' regions.

P-wr

P-rr cDNA sequences


Input: Because the hcf109 locus was mapped at a distance < 0. 1 centimorgans from the phytochrome C gene, its molecular characterization by positional cloning is possible.

hcf109 locus

phytochrome C gene


Input: The human MSH-2 gene product is a member of a highly conserved family of proteins which are involved in post-replication mismatch repair. hMSH-2 is homologous to Escherichia coli (E. coli) MutS and Sacchromyces cerevisiae MSH-1 and MSH-2 proteins, which recognise heteroduplex DNA at the sites of all single base mismatches and deletions or insertions up to 4 base pairs. hMSH-2 is one of the hereditary non-polyposis colorectal cancer (HNPCC) tumor suppressor genes, and maps to human chromosome 2p16.

human MSH-2 gene product

MutS

Sacchromyces cerevisiae MSH-1

MSH-2 proteins

hereditary non-polyposis colorectal cancer (HNPCC) tumor suppressor genes


Input: We have recently shown that the tissue-specific expression of the RAR beta 2 gene in mouse embryos is regulated at the translational level by short upstream open reading frames (uORFs) In the 5'-untranslated region (Zimmer, A., A. M.

RAR beta 2 gene in mouse embryos


Input: We have previously isolated a cDNA for a transcription factor referred to as Zfhep (zinc finger homeodomain enhancer-binding protein) containing two separate zinc finger domains, ZD1 and ZD2, each of which binds DNA, and a homeodomain.

Zfhep

zinc finger homeodomain enhancer-binding protein


Input: Increased PTHRP production by a tyrosine kinase oncogene, Tpr-Met: role of the Ras signaling pathway.

PTHRP

tyrosine kinase oncogene

Tpr-Met

Ras


Input: Subsequent to their secretion, the IGF-II in xz97 and G11 cells accumulated in the conditioned medium mostly as two partially processed species with appMr, of 17K and 14K, respectively.

IGF-II


Input: Paradoxically, coexpression of the transcriptionally inactive, amino-terminally deleted IDX-1 mutant proteins, either with the wild-type IDX-1 or with themselves, results in a marked enhancement of transactivation of the transcriptional TAAT-1 element reporter.

IDX-1 mutant proteins

wild-type IDX-1

TAAT-1 element reporter


Input: All patients had abnormal von Willebrand factor (vWF) fragmentation as reflected by decreased high molecular weight and increased low molecular weight vWF multimers in the circulation.

von Willebrand factor

vWF

vWF multimers


Input: In an attempt to investigate whether the intergenic region between the oleosin and a second open reading frame (ORFII) in Brassica napus (L.) is a divergent promoter, and also to characterize the ORFII, cDNA clones homologous to ORFII were isolated from a leaf cDNA library.

oleosin

ORFII

cDNA clones homologous to ORFII


Input: The ORFII gene product is targeted to the chloroplast, which is consistent with previous data indicating the presence of PMSR activity in the chloroplast.

ORFII gene product

PMSR


Input: Characterization of LRP, a leucine-rich repeat (LRR) protein from tomato plants that is processed during pathogenesis.

LRP

leucine-rich repeat (LRR) protein from tomato plants


Input: To test whether Sp1 and zif268/egr-1 interact with this motif, gel retardation assays were performed.


Input: OBJECTIVES: The aim of the study was to analyze the clinical characteristics, treatment and outcome of 310 patients with hydatidiform mole.


Input: Stably transfected human kidney 293 cells expressing the wild type rat LH/CG receptor (rLHR) or receptors with C-terminal tails truncated at residues 653, 631, or 628 (designated rLHR-t653, rLHR-t631, and rLHR-t628) were used to probe the importance of this region on the regulation of hormonal responsiveness.

wild type rat LH/CG receptor

rLHR


Input: Are low P300 amplitudes a marker for schizophrenia.


Input: Sleep was determined again for an additional 3 days and 6 hours.


Input: The patients are two healthy adult males.


Input: Indoor concentrations were only weakly correlated with outdoor concentrations, however, and personal exposures were even more poorly correlated with outdoor concentrations.


Input: A neuropsychological test battery was used that contained the Wisconsin card sorting test, Street completion test, Stroop test, a dichotic memory listening test, and a facial recognition test.


Input: We present this case because of the rarity of left ventricular involvement associated with ARVD.


Input: In a randomized single-blind 3 x 3 Latin-square study with corrections for any carryover effects, 27 males and 30 females consumed supplements containing glucose or resistant starch (RS) from raw high-amylose cornstarch (RS2) or from retrograded high-amylose cornstarch (RS3).


Input: The 5' flanking region of the mouse Met-ase-1 gene also shares considerable regions of identity with the 5' flanking region of the rat Met-ase-1 gene.

mouse Met-ase-1 gene

rat Met-ase-1 gene


Input: The [18F] FMISO TMRR is a simple and clinically useful index for detecting tumour hypoxia in NPC.


Input: Improved methods have been developed for maintaining and breeding the neotropical short-tailed fruit bat, Carollia perspicillata, in an easily-reproduced, laboratory setting.


Input: In addition, the time to engraftment was significantly shorter in the amifostine arm in both cohorts.


Input: We conclude that CPET is a useful investigation in the management of patients with cardiopulmonary disease and complements the various other investigations offered by a pulmonary function laboratory.


Input: Using fluorescence in situ hybridization, we mapped the chromosome-17 breakpoint in a patient with acampomelic CMPD and sex reversal, who carries a de novo constitutional t (12; 17) translocation, between two known cosmid markers in the 17q24-q25 region.


Input: This is concluded from the isolation of cDNAs from spinach (Spinacia oleracea) and barley (Hordeum vulgare cv.


Input: The data presented in this work indicate that thi1 may also be involved in DNA damage tolerance in plant cells.


Input: In the rat rnu allele described here, a nonsense mutation in exon 8 of the whn gene was identified.

rat rnu allele

whn gene


Input: Control intact rats were age-matched to the different treated groups.


Input: DESIGN: A cross-sectional study.


Input: We have identified a strong Tas-responsive element, designated TRE (GP), near the 3' end of the gag gene and preceding the pol gene of SFV-1.

Tas-responsive element

TRE

GP

gag gene

pol gene


Input: Although the binding of IE2 86 to nonphosphorylated full-length CREB or deltaCREB is minimal, IE2 86 does form complexes with p300 and the CREB-binding protein (CBP), which in turn bind to CREB and can serve as adaptor proteins for CREB function.

IE2 86

full-length CREB

deltaCREB

IE2 86

CREB-binding protein

CBP

CREB

CREB


Input: A transgenic complementation assay was used to test whether NIa supplied in trans could rescue amplification-defective viral genomes encoding altered NIa proteins.

NIa

NIa proteins


Input: On the basis of its bZIP structural homology, meq is perhaps the only member of the jun-fos gene family completely viral in origin.

meq

jun

fos


Input: The rCBF and vasomotion were recorded by laser-doppler fluxmetry.


Input: Although basal vessels may constrict distal parenchymal vessels tend to dilate after SAH.


Input: The triple combination of nizatidine, clarithromycin, and bismuth subcitrate resulted in an ulcer healing rate of 98% and an H. pylori eradication rate of 90%.


Input: Several lines of evidence presented here suggest that PKC-zeta plays a role in alpha 2 integrin gene expression.

PKC-zeta

alpha 2 integrin gene


Input: Plasma thrombomodulin: a marker for microvascular complications in diabetes mellitus.

thrombomodulin


Input: Update: diphtheria epidemic in the newly independent states of the former USSR, January 1995-March 1996.


Input: The characterization of the promoter region indicated that three distinct regulatory elements corresponding to an AP-1 binding site (or TRE), a PRDII/kappaB domain, and a CAAT box are involved in the activation by pp60 (v-) src.

AP-1 binding site

PRDII

kappaB

pp60 (v-) src


Input: Serine 528 is phosphorylated in vivo in several cell lines, and substitution of serine 528 to alanine (S528A) resulted in an increased ability of Myb to transactivate a synthetic promoter containing five copies of the mim-1A Myb-responsive element and a minimal herpes tk promoter.

Myb

mim-1A Myb

herpes tk promoter


Input: The DNA binding and multimerization activities of c-Myb appear to be unaffected by the S528A substitution, suggesting that phosphorylation of serine 528 may mediate its effect on the transcription transactivating activity of c-Myb by regulating interactions with other proteins.

c-Myb

c-Myb


Input: The amount of these factors was reduced in GEO cells in which the u-PAR gene is only weakly transcriptionally activated.

u-PAR gene


Input: PIP2, when incorporated into phosphatidylcholine carrier vesicles, binds tightly to the guanine nucleotide-depleted form of Cdc42Hs and weakly to the GDP-bound form of the GTP-binding protein but does not bind to GTP-bound Cdc42Hs, similar to what was observed for the Dbl oncoprotein.

GTP-binding protein

Dbl oncoprotein


Input: Purified spleen GAP accelerated hydrolysis of GTP bound to recombinant ARF1, ARF3, ARF5, and ARF6; no effect of NH2-terminal myristoylation was observed.

GAP

recombinant ARF1


Input: Biol.


Input: A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells.

Cbl


Input: Cys-757 within the (Fe4S4)-siroheme-binding domain was essential for native enzyme activity.


Input: Its transcription has been shown to be induced 40-50-fold in response to oxygen or heme deficiency, in part through relief of repression exerted by Rox1p and in part by activation mediated by an upstream activation sequence (UAS).


Input: Altogether, our results indicate that the transcriptional activity of Cut proteins is modulated by PKC.

Cut proteins

PKC


Input: Lck has been postulated to dimerize through the SH2 and SH3 domains.

Lck

SH3 domains


Input: Furthermore, freezing in the presence of bovine lactalbumin resulted in a good maintenance of the cellular viability and of the CCCD heterogeneity in respect to fresh cells.

bovine lactalbumin


Input: Myelomatous pleural effusion as presentation form of multiple myeloma


Input: The presence of unidentified macroscopic or microscopic clusters of neoplastic cells, lying around, more or less close to, the line of insertion of lesion, could render any attempt to gain a " radical " excision useless.


Input: The partial categories of the SIP that were more affected were work, recreation and pastimes, home management, and sleep and rest.


Input: Northern blot analysis, using the Ltp4-specific probe, indicated that Xanthomonas campestris pv. translucens induced an increase over basal levels of Ltp4 mRNA, while Pseudomonas syringae pv. japonica caused a decrease.

Ltp4 mRNA


Input: Furthermore, the use of zero-loss filtering in combination with exit wavefront reconstruction is considerably more effective at removing the effects of multiple elastic and inelastic scattering and microscope objective lens aberrations than either technique by itself.


Input: Transcripts for both ODV-E18 and ODV-EC27 initiate from conserved TAAG motifs, and transcripts are detected from 16 through 72 hr p. i.


Input: In order to determine which sequences in the GATA-1 promoter are crucial for activation by the ME26 viral protein, we made deletions of the promoter, cloned them into a luciferase expression vector and tested their activity in mouse fibroblasts, which do not express GATA-1.

GATA-1 promoter

ME26 viral protein

luciferase


Input: A 3-yr retrospective review is effective and detects 94% of the undercalls.


Input: Isolation and identification of genes activating UAS2-dependent ADH2 expression in Saccharomyces cerevisiae.

UAS2-dependent ADH2


Input: METHODS AND RESULTS: A 64-year-old woman with confirmed AV nodal reentrant tachycardia underwent a successful " slow pathway " AV modification with a single radiofrequency application.


Input: Patients with low probability of having aluminum overload (serum iron levels < 40 micrograms/L and DAI < 150 micrograms/L) had significantly higher values of serum iron, iron transferrin saturation, and serum ferritin levels compared with those patients with a high probability of having aluminum overload (serum aluminum levels > 40 micrograms/L and DAI > 150 micrograms/L).

transferrin

serum ferritin


Input: Although the RAD23 equivalents are well conserved during evolution, the mammalian genes did not express the UV-inducible phenotype of their yeast counterpart.


Input: Ha-RasV12 and activated proteins in both the extra-cellular regulated kinase (ERK) and the stress-activated protein kinase (SAPK) or Jun N-terminal kinase (JNK) cascades independently stimulated PEA3-mediated gene expression.

extra-cellular regulated kinase

ERK

stress-activated protein kinase

SAPK

Jun N-terminal kinase

JNK


Input: Sequence analysis of reverse transcribed, amplified cDNA generated from total RNA isolated from transfected cells demonstrated the presence of abnormally spliced products containing 13 and 78 additional bases as well as the accumulation of unspliced mRNA.


Input: A 1. 5-kb HindIII genomic fragment carrying the vspA gene from M. bovis PG45 was cloned and sequenced.

HindIII

vspA


Input: Carbon catabolite repression of the gnt operon of Bacillus subtilis is mediated by the catabolite control protein CcpA and by HPr, a phosphocarrier protein of the phosphotransferase system.

gnt operon of Bacillus subtilis

CcpA

HPr


Input: Melatonin and seasonality: filling the gap.


Input: A subsequent screen for the loss of the positively selectable target locus marker detects the desired replacement at modest frequency (> 2%).


Input: Here we demonstrate that another cellular protein linked to BCR/ABL through the CRKL-SH2 domain is p130 (CAS). p130 (CAS) was found to be tyrosine phosphorylated and associated with CRKL in BCR/ABL expressing cell lines and in samples obtained from CML and ALL patients, but not in samples from controls.

BCR

ABL

CRKL

CAS

CAS

CRKL

BCR

ABL


Input: The effects of procedural variations on lateralized Stroop effects.


Input: In a third experiment, a Chessmaster gradually increases the number of boards he can reproduce with higher than 70% average accuracy to nine, replacing as many as 160 pieces correctly.


Input: PCNA mRNA has a 3' UTR antisense to yellow crescent RNA and is localized in ascidian eggs and embryos.

PCNA mRNA


Input: A 1. 8-kb cDNA clone (designed hKID, gene symbol AQP2L) with homology to the aquaporins was isolated from a human kidney cDNA library.

hKID

gene symbol AQP2L

aquaporins


Input: PCR/Southern blot analysis of human kidney cDNA using primers flanking the hKID coding sequence revealed expression of a full-length mRNA and short transcripts with partial exon 1 and partial exon 4 deletions.

hKID coding sequence


Input: The high sequence homology, similar genomic structure, and identical chromosomal loci of hKID, MIP, and AQP-2 suggest a MIP family gene cluster at chromosome locus 12q13.

hKID

MIP

MIP family gene cluster


Input: The third ORF generates a transcript of 1. 6 kb and encodes a protein of 382 residues including a perfect match to the consensus sequence of a C2H2 zinc finger domain; it shares a strong homology with yeast Mig1p and Cre-A from Aspergillus, Emericella and E. coli.

yeast Mig1p

Cre-A from Aspergillus, Emericella and E. coli


Input: Adding phytase and nP improved the orderliness of development, mineralization and arrangement of cartilage and bone cells, and alleviated the effects of P deficiency on the histological and gross structure of the tibias.

phytase


Input: The importance of temporal factors on the presence and severity of ethanol withdrawal signs in the rat was quantified using rating scale, tremor, and acoustic startle paradigms.


Input: Data supported the brevity of the WISC-III short form and the criterion-related validity of both the K-FAST and and Kaufman Short Neuropsychological Assessment Procedure (K-SNAP).


Input: Thus, the multidomained ROK alpha appears to be involved in reorganization of the cytoskeleton, with the N and C termini acting as positive and negative regulators, respectively, of the kinase domain whose activity is crucial for formation of stress fibers and focal adhesion complexes.

ROK alpha


Input: These findings and the differential tissue distribution of p54 suggest that this novel SR protein may participate in regulation of alternative splicing in a tissue-and substrate-dependent manner.

SR protein


Input: The elevation of cyclic AMP (cAMP) levels in the cell downregulates the activity of the Raf-1 kinase.

Raf-1 kinase


Input: An interaction screen with the repression domain of the orphan receptor RevErb identified N-CoR, the corepressor for thyroid hormone receptor (TR) and retinoic acid receptor (RAR).

orphan receptor RevErb

N-CoR

thyroid hormone receptor

TR

retinoic acid receptor

RAR


Input: These results indicate that inhibition of Jun kinase activation was sufficient to inhibit Ras transformation even in the presence of activated Erk-2.

Jun kinase

Ras


Input: Our analysis suggests that Upf1p is a multifunctional protein with separable activities that can affect mRNA turnover and nonsense suppression.


Input: Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe.


Input: Two closely related variants of Stat5, Stat5a and Stat5b, are encoded by distinct genes.


Input: Mutations in three loci (SIC1, SWI5, and RIC3) were identified.


Input: The serine/threonine kinase Raf-1 functions downstream of Rats in a signal transduction cascade which transmits mitogenic stimuli from the plasma membrane to the nucleus.

serine/threonine kinase Raf-1

Rats


Input: In transient cotransfections E1A could induce the activity of the p53 promoter to a high level; 12S E1A was threefold as efficient as 13S E1A in this activity, and YY1 bound to the composite element was shown to mediate 55% of this induction.

p53 promoter

12S E1A

13S E1A


Input: The retinoid Z receptor beta (RZR beta), an orphan receptor, is a member of the retinoic acid receptor (RAR)/thyroid hormone receptor (TR) subfamily of nuclear receptors.

retinoid Z receptor beta

RZR beta

retinoic acid receptor

RAR

thyroid hormone receptor

TR


Input: DNA-dependent protein kinase (DNA-PK) consists of a heterodimeric protein (Ku) and a large catalytic subunit (DNA-PKcs).

DNA-dependent protein kinase

DNA-PK

Ku

DNA-PKcs


Input: Sequencing of the 16p 11. 1/Xq28 duplication breakpoints has revealed the presence of repetitive immunoglobulin-like CAGGG pentamer sequences at or near the paralogy boundaries.

immunoglobulin-like CAGGG pentamer sequences


Input: However, in a multivariate analysis considering age, gender, and a previous history of cardiovascular diseases, female gender was not independently associated with death.


Input: Moreover, following a single intravenous injection of the bicistronic vector complexed to cationic liposomes into recipient mice, delivery of MDR1 and GC cDNAs was achieved in all the organs we tested.

GC cDNAs


Input: The limits of agreement between DBS and TOF responses were so wide that they cannot be used interchangeably.


Input: The harpin-encoding hrpZ gene is located in an operon that also encodes Hrp secretion pathway components and is part of the functional cluster of hrp genes carried on cosmid pHIR11 that enables saprophytic bacteria like Escherichia coli and Pseudomonas fluorescens to elicit the HR in tobacco leaves.

harpin

hrpZ gene

Hrp secretion pathway components

hrp genes


Input: Despite the presence of one additional ribonucleotide reductase, the nrdAB-encoded enzyme is essential to the aerobic growth of the cell because nrdAB-defective mutants of both species are not viable in the presence of oxygen.

ribonucleotide reductase

nrdAB-encoded enzyme

nrdAB-defective mutants


Input: Altogether, the results demonstrate that the two isoforms elicit similar responses in vivo despite differences in their regulation.


Input: Motivational factors focusing on attitudes, perceived susceptibility to pregnancy, and normative factors were also relevant.


Input: High-resolution structure of the diphtheria toxin repressor complexed with cobalt and manganese reveals an SH3-like third domain and suggests a possible role of phosphate as co-corepressor.

diphtheria toxin repressor


Input: Titration of the human and porcine proteins with 2-nitro-5-thiosulfabenzoate indicates that membrane dipeptidase additionally possesses two intrachain disulfide bonds.

membrane dipeptidase


Input: FEV1 did not fall significantly in patients without acute or chronic GVHD and recovered earlier than in patients without posttransplant pulmonary infection.


Input: Administration of adrenaline resulted in a large overestimation of the SaO2 in 6 of the 7 measurements.


Input: Therapy with dietary modification and triglyceride lowering drugs resulted in resolution of symptoms and parotid swelling in one patient.


Input: Chernoff, submitted for publication).


Input: We have cloned a novel protein kinase, termed hematopoietic progenitor kinase 1 (HPK1), that is expressed predominantly in hematopoietic cells, including early progenitor cells.

hematopoietic progenitor kinase 1


Input: Human ESP1/CRP2 protein has two LIM domains, and each shares 35. 1% and 77 or 79% identical residues with human cysteine-rich protein (CRP) and rat CRIP, respectively.

LIM

human cysteine-rich protein

CRP

rat CRIP


Input: The fragments are separated and directly sized by agarose gel electrophoresis.


Input: Linkage studies have shown locus heterogeneity with one TSC gene mapped to chromosome 9q34 and a second to 16p13. 3.

TSC gene


Input: The cytogenetic expression of the folate sensitive fragile site, FRAXE, is due to the expansion of a GCC repeat in proximal Xq28 of the human X chromosome and is associated with a mild form of mental handicap.

FRAXE


Input: DNA sequence analysis of a 3213 bp BamHI-ClaI fragment revealed that three open reading frames (ORFs) were encoded in the same orientation.

BamHI

ClaI


Input: The initial inpatient experience for individuals with HIV-related TB may be pivotal to the acceptance of and participation in ongoing TB care.


Input: This element, termed CREsp-a (TGACCTCA), differs by one nucleotide from a palindromic CRE (CREpal, TGACGTCA), which is known to bind CREB as a homodimer.

CREB


Input: Analysis of human genomic DNA reveals an intronless sequence with strong homology to human G alpha q cDNA.

human G alpha q cDNA


Input: The complete exon-intron structure of the 156-kb human gene NFKB1, which encodes the p105 and p50 proteins of transcription factors NF-kappa B and I kappa B-gamma: implications for NF-kappa B-mediated signal transduction.

156-kb human gene NFKB1

p50 proteins

NF-kappa B

I kappa B-gamma

NF-kappa B


Input: An inverted Alu repeat element, flanked by nonamer direct repeats, was identified within the region-913/-620, relative to the cap site.

Alu


Input: Comparison of the amino acid sequences of the RPO1 polypeptides of IIV6, LCDV, and MCV-1 with the corresponding prokaryotic, eukaryotic, and viral proteins revealed differences in amino acid similarity and phylogenetic relationships.

RPO1 polypeptides of IIV6, LCDV, and MCV-1


Input: The RPO1 of LCDV shows the highest similarity to the RPO1 of IIV6 and significant lower similarity to the eukaryotic polymerases II and III as well as to the archaebacteral subunit.

eukaryotic polymerases II and III


Input: The use of primary GE cells thus provides a convenient in vitro system for further study of the endocrine, paracrine, and autocrine factors regulating endometrial gene expression during pregnancy.


Input: We performed dipole estimation of spikes and SEP components in identical patients.


Input: Proximal CBD was inversely correlated with bone alkaline phosphatase (r =-0. 71, p < 0. 01) and intact PTH (r =-0. 59, p < 0. 05).

bone alkaline phosphatase

PTH


Input: In addition, a comparison of the hCHLR gene sequences with available databases indicates that a large portion of these genes, including exons encoding two functional domains of the carboxyl-terminal region of these proteins, has been duplicated as part of a larger human telomeric repeat sequence found on many human chromosomes.

hCHLR gene sequences


Input: We show here that the LIM domain homeobox protein isl-1 activates the rat amylin promoter in both fibroblast and islet cell lines.

LIM domain homeobox protein isl-1

rat amylin promoter


Input: Although isl-1 binds to both the insulin and amylin gene promoter elements in vitro, these sequences display marked differences in their relative transcriptional properties when ligated adjacent to a heterologous promoter and transfected into InR1-G9 islet cells.

insulin

amylin gene promoter elements


Input: It is likely that other pathways involve alternate signal transduction events (e. g., calcium mobilization) and promoter response elements (e. g., SRE).


Input: The CD4 count at which remission occurs may reflect severe immunodeficiency such that risk for AIDS-related infection is high.


Input: Although diagnostic laparoscopy is still considered the standard reference in the diagnosis of ectopic pregnancy (EP), use of high-resolution endovaginal sonography, in conjunction with qualitative serum assays of the beta subunit of human chorionic gonadotropin (beta-hCG), allows detection of earlier and smaller EPs.

human chorionic gonadotropin

beta-hCG


Input: Bifunctionality of the AcMNPV homologous region sequence (hr1): enhancer and ori functions have different sequence requirements.

AcMNPV homologous region sequence


Input: Neither CES1 nor CES4 is essential for cell growth, and a double deletion mutant is viable.


Input: Their use established that the BrAAP activity catalyzed both a postproline and a postglutamate cleavage and therefore has a broader specificity than previously recognized.


Input: To explore the functional significance of these subdomains in PRL binding and signal transduction, deletion mutants of S1 or/and S2 subdomains were constructed.

PRL


Input: A stable heterologous cell line containing the mouse TRH receptor was constructed by transfection of nonexcitable 293 cells, which lack L channel activity.

mouse TRH receptor


Input: To understand further the expression and regulation of the V1aR, we now describe the genomic characteristics, tissue expression, chromosomal localization, and regional mapping of the human V1aR gene, AVPR1A.

human V1aR gene


Input: The final predicted structure has an overall backbone deviation of 0. 7 A from that of ras-p21.

ras


Input: Genomic organization of the human beta-catenin gene (CTNNB1).

human beta-catenin gene


Input: Furthermore, although the regional distribution of lean tissue mass in the trunk and legs remained fairly constant at different pubertal stages, the regional distribution of fat was altered significantly, becoming more central and less peripheral.


Input: Thus, the predicted CD30v protein retains most of the cytoplasmic region, but lacks the extracellular and transmembrane domains.

CD30v protein


Input: Constitutive phosphorylation of the CD30v protein was demonstrated by in vitro labeling with [32P].

CD30v protein


Input: 17. 5% of cycles).


Input: We report here the discovery of a new actin-related gene in this organism, which we have named ACT4.

actin-related gene


Input: Two of the ORFs are completely internal to longer ones and a third is partially embedded in G2850.


Input: MVR typing of rare-length alleles indicates that they are comprised of disorganized sequences, although they usually bear a resemblance to one of the common alleles at the 5'-most end.


Input: Plasmid pAL618 contains the genetic determinants for H2 uptake (hup) from Rhizobium leguminosarum bv. viciae, including a cluster of 17 genes named hupSLCDEFGHIJK-hypABFCDE.

hup

hupSLCDEFGHIJK-hypABFCDE


Input: An open-label, placebo-controlled, randomized, two-way crossover study was performed in 12 healthy volunteers (between 20 and 44 years of age) to assess the effect of orlistat, a gastrointestinal lipase inhibitor that reduces dietary fat absorption and is being developed for weight control in obesity, on the absorption of vitamins A and E.

gastrointestinal lipase


Input: Tilmicosin is a novel macrolide antibiotic developed for exclusive use in veterinary medicine.


Input: Effect of nitrous oxide (N2O) on the somatosympathetic A-and C-reflexes was investigated using artificially ventilated rats anesthetized with alpha-chloralose and urethane.


Input: Restriction enzyme mapping and Southern analysis indicated further that the human MZF-1 gene is a single-copy gene.

human MZF-1 gene


Input: In the absence of Swi4 and Swi6 cell viability is lost, but can be regained by ectopic expression of the G1 cyclin encoding genes, CLN1 or CLN2.

G1 cyclin encoding genes


Input: The detection ratio peaked at ages 30 to 34 and decreased heavily during the next 15 years of age.


Input: How many embryos to transfer in patients undergoing IVF?


Input: The nonconsensus TATA box in promoter B plays a more important role in promoter activity than the TATA box in promoter A.


Input: These properties indicate that Gle1 is an RNA-export factor and that Rev may mediate viral RNA export by mimicking the function of Gle1.

Rev


Input: Demispan is a reliable and reproducible measure of stature in the elderly.


Input: Two techniques based on assay coefficients of variation were employed to characterize a normal circadian pattern of cortisol.


Input: A system is described in which the volume flow rate of blood in a vessel is determined using transverse colour Doppler ultrasound imaging.


Input: The enzyme activities studied are important elements in the pathophysiology of dental caries and may even be addressed as virulence factors.


Input: In lean mice, the fat/water intensity ratio was about 1: 4, about half that in normal mice.


Input: Pharmacokinetic parameters were similar to values given in the literature for intravenous (IV) or intraarterial (IA) bolus MMC injections (Tmax = 7. 0 min following the beginning of MMC infusion, Vss = 0. 57 1/kg, C1 = 8. 9 ml/min. kg, T1/2 alpha = 8. 3 min, T1/2 beta = 58. 6 min).


Input: In this study, we identified four distinct E2F complexes present in aged and senescent normal, human diploid fibroblasts.

E2F complexes


Input: This paper gives an overview of the global pattern of casualties in earthquakes which occurred during the 30-month period from 1 September 1993 to 29 February 1996.


Input: If we apply the finding of non-visualization of the GB at 4 h post injection as the criterion for the diagnosis of AC, the diagnostic accuracy was only 40. 7% (11/27).


Input: Alternative processing of the tryptophanyl-tRNA synthetase mRNA from interferon-treated human cells.

tryptophanyl-tRNA synthetase mRNA

interferon


Input: Evidence for the promoting role of the intra-uterine kinin release in the development of late hypertonic saline-induced abortion.

intra-uterine kinin


Input: This GAP activity was observed in 3T3-L1 adipocyte lysates, and was able to accelerate the hydrolysis of the [alpha-32P] GTP bound to GST-Rab4 into [alpha-32P] GDP.

GAP

GST


Input: CONCLUSION: During chronic treatment, the haemodynamic response to oral cilazapril was attenuated, indicating that continued clinical improvement in patients with CHF on CLZ is independent of to its acute haemodynamic effects.


Input: We conclude that, in AIDS patients with cryptococcosis, tolerance to ILd-AmB was acceptable when the daily dosage did not exceed 1 mg/kg, but the higher 1. 5 mg/kg daily dosage was associated with an unacceptable rate of nephrotoxicity.


Input: Moreover, the second RCC1-like motif located at the amino-terminus of p619 stimulates guanine nucleotide exchange on ARF1 and on members of the related Rab proteins, but not on other small GTP binding proteins such as Ran or R-Ras2/TC21.

RCC1-like motif

Rab proteins

small GTP binding proteins

Ran


Input: The reconstituted RNA polymerases containing the mutant alpha subunits were examined for their response to transcription activation by cAMP-CRP and the rrnBP1 UP element.

RNA polymerases

cAMP-CRP

rrnBP1 UP element


Input: Transcription factor recognition surface on the RNA polymerase alpha subunit is involved in contact with the DNA enhancer element.

RNA polymerase alpha subunit


Input: Consistent with this similarity, the cdc28-P8 mutant accumulates unspliced precursors at the restrictive temperature.


Input: A decrease of erythrocyte Mn with age, expressed in nmol/L, was noted (p < 0. 02).


Input: Cloning and sequence analyses revealed a second cDNA with a 95-nt deletion in the region coding for the putative second intracellular loop and the fourth transmembrane domain of the 5-HT2C-R.


Input: Expression of thymidine kinase gene in normal human diploid cells is both cell cycle-and age-dependent and appears to be transcriptionally regulated.

thymidine kinase gene


Input: The minimum inhibitory concentrations (MICs) of ketoconazole, miconazole, itraconazole, fluconazole, and amphotericin B were significantly influenced by the inoculum size, regardless of the techniques used.


Input: These bacteria produce and export proteins capable of specific interactions with key mammalian cell regulatory molecules in order to derail the normal functions of the cells.


Input: Thus, although p28 may play only a limited role during the early embryonic cleavages, it may function later in development to establish a somatic type of cell cycle.


Input: The main aim of the contribution, which opens an arena for discussion on the Rivista dell' Infermiere is to critically appraise published research works focusing both on strengths and novelty and weaknesses in the hypothesis formulation, methods and instruments used, discussion of results.


Input: Moreover, it also discusses the effects of antihypertensive drugs currently regarded as first-choice agents, i. e. calcium antagonists and the angiotensin converting enzyme inhibitors, on intrarenal hemodynamics.

angiotensin converting enzyme


Input: It is suggested that the observed clinical phenomena in response to morphine can be explained by differences in expression and sensitivity of some opioid receptor subtypes in migraine.

opioid receptor


Input: Previous studies demonstrated that the flavin-containing monooxygenases (FMO) are expressed in a tissue-specific manner.

flavin-containing monooxygenases

FMO


Input: Thus, despite the potential for common regulatory mechanisms, the available evidence indicates that the Mtx minimal promoter does not significantly affect Thbs3 gene expression.

Mtx minimal promoter

Thbs3 gene


Input: MSSP proteins have been identified by their binding to an upstream element of c-myc.

MSSP proteins

c-myc


Input: Gene 1 has been completely sequenced.

Gene 1


Input: B cell antigen receptor (BCR)-induced apoptosis in the WEHI-231 B lymphoma cell line can be prevented by engaging CD40.

B cell antigen receptor

BCR


Input: Both alleles are functionally expressed and are distributed within CD4 +/CD8 + T cell subsets.


Input: The deduced amino acid sequence of LvUSF2 is nearly identical to LvUSF1 except at the amino end, where they are sharply divergent.


Input: ECM disruption in Lytechinus embryos caused a relative drop in USF RNA accumulation levels to approximately 60% of control embryos, while LpS1 RNA accumulation levels dropped to less than 5%.

USF RNA

LpS1 RNA


Input: Five of these eight patients in group II also received 8-in-1 chemotherapy.


Input: Sixty days after the intervention, twitch and tetanic tensions remained dependent upon the extracellular Ca2 + concentration ([Ca] o) both in groups A and B.


Input: Recently, a distantly related UmuC-homolog, DinB, has also been identified in E. coli.

UmuC-homolog

DinB


Input: To study the regulation of mdr2 expression, the promoter of the mdr2 gene has been isolated from a murine vinblastine-resistant cell line, J7. V2-1, and characterized.

mdr2 gene


Input: The amplification was achieved using two primers which correspond to TRH progenitor sequence (Lys/Arg-Arg-Gln-His-Pro-Gly-Lys/Arg-Arg).

TRH progenitor sequence


Input: The intranodal mesothelial cells occupied the sinusoids of the lymph nodes and were initially suspected of being metastatic from the ovarian tumor in each case.


Input: The gene ccpA encoding the catabolite control protein CcpA of Staphylococcus xylosus has been cloned and characterized.

gene ccpA

catabolite control protein CcpA


Input: An InlC deletion mutant shows reduced virulence when tested in an intravenous mouse model, but intracellular replication of the mutant in Caco-2 and J774 cells appears to be comparable with that of the wild-type strain.

InlC deletion mutant


Input: Thus, the N-Nus complex may be affected through contacts with the CTD of the alpha subunit of RNA polymerase, as is a group of regulatory proteins that influences initiation of transcription.

N

Nus

RNA polymerase


Input: Administration of RIFA at 200 mg/kg/day in combination with ATO at 100 mg/kg/day resulted in a marked prolongation of survival compared with that for mice that received ATO or RIFA alone.


Input: Two of seven initiation sites were flanked by a sequence homologous to the consensus promoter motif that includes the CRTA motif (where R is A or G) of the rice mitochondrion.


Input: Selection using SC EPD was more effective than phenotypic selection in reducing age at puberty in daughters.


Input: Sodium polystyrene sulfonate treatment for lithium toxicity: effects on serum potassium concentrations.


Input: The mammalian homeodomain proteins encoded by Hox genes play an important role in embryonic development by providing positional queues which define developmental identities along the anteroposterior axis of developing organisms.

mammalian homeodomain proteins

Hox genes


Input: Interferon stimulated gene factor 3 (ISGF3) is a trimeric transcription factor activated on treatment of cells with interferon-alpha and beta (type I IFNs).

Interferon stimulated gene factor 3

interferon-alpha and beta

type I IFNs


Input: The TYAC/P1 resource, derivative STSs, and polymorphisms constitute an enabling resource to further studies of telomere structure and function and a means for physical and genetic map integration and closure.


Input: Confirmatory statistics included item 2 of the Clinical Global Impression (CGI), the total score of the Sandoz Clinical Assessment Geriatric (SCAG) scale, the subscale' need for help' of the nurse' s rating of geriatric patients (Beurteilungsskala fur geriatrische Patienten; BGP) and the total score of the Short Cognitive Performance Test (Syndrom-Kurztest; SKT).


Input: Three mutants were isolated from the widely used strain, PAO1.


Input: As extensively examined with the myogenin promoter, presence of one or multiple copies of Me in the vectors elevated the expression activity in myotubes by 4. 5-to 19-fold over those without Me, but not significantly in myoblasts.

myogenin promoter

Me

Me


Input: We conclude that common upstream signals cause activation of Ras and TC21, but activated TC21 controls cell growth via distinct Raf-independent downstream signaling pathways.

Ras

Raf


Input: Fission yeast mal2 + is required for chromosome segregation.

Fission yeast mal2 +


Input: Selection was based on expression of an integrated DNA fragment containing the con-10 promoter-regulatory region followed by the initial segment of the con-10 open reading frame fused in frame with the bacterial hygromycin B phosphotransferase structural gene (con10'-' hph).

con-10 promoter-regulatory region

con-10 open reading frame

bacterial hygromycin B phosphotransferase structural gene

con10'-' hph


Input: Mutations at two neighboring sites, serine 242 and threonine 255, exacerbated the effect.


Input: IRF-1 acts as a transcriptional activator, while IRF-2 acts as a repressor.


Input: In contrast, cotransfection of TFIIB and IRF-1 into NIH 3T3 cells resulted in a dose-dependent repression of promoter activation which occurred in a TATA-dependent manner.

TFIIB


Input: The requirement of Tyr-19 dephosphorylation for spindle assembly is also observed under conditions in which spindle formation is independent of mitosis, suggesting that the involvement of Cdc28/Clb kinase in SPB separation is direct.

Clb


Input: Expression of the proapoptotic protein Bax under the control of a GAL10 promoter in Saccharomyces cerevisiae resulted in galactose-inducible cell death.

proapoptotic protein Bax

GAL10 promoter


Input: This technique was employed in 12 patients with a unicameral bone cyst.


Input: The amino-terminal region of E1A binds several high molecular weight proteins and inhibits the transcriptional coactivator function of p300 and the homologous cAMP response element (CRE)-binding protein.

cAMP response element (CRE)-binding protein


Input: Transient transfection assays using reporter gene constructs containing various lengths of the 5' mdr1b sequences revealed that the sequence located between-247 to-126 bp was important for the expression of the reporter gene in many different cell lines.

5' mdr1b sequences


Input: We show that the 5' UTR characteristic of testis-specific c-mos mRNA strongly represses translation relative to the translation of transcripts that contain a 5' UTR derived from beta-globin mRNA, and this is mainly due to the four uORFs.

testis-specific c-mos mRNA

beta-globin mRNA


Input: To address the biological effect of specific isoform expression, NIH3T3 cells were transfected with a eukaryotic expression vector containing cDNA for FGF8a, FGF8b, or FGF8e.


Input: These findings suggest that the F-wave may be elicited in motoneuron of different depolarization threshold but primarily in larger and faster nerve fibers, with a lower threshold of depolarization.


Input: In addition, carp JAK1 shows higher sequence homology to mammalian JAK1 in both the kinase-like (JH2) and kinase (JH1) domains (approximately 70% identity).

carp JAK1

mammalian JAK1


Input: When this DNA fragment was placed upstream of the chloramphenicol acetyltransferase (CAT) reporter gene and transfected into a carp CF cell line, it could drive the synthesis of CAT enzyme 16 times more efficiently than the promoterless pCAT-Basic.

chloramphenicol acetyltransferase

CAT

CAT enzyme

pCAT-Basic


Input: Molecular cloning of Elk-3, a new member of the Ets family expressed during mouse embryogenesis and analysis of its transcriptional repression activity.

Ets family


Input: We report an example of an MDV-transformed T-lymphoblastoid cell line (T9) expressing high levels of a truncated C-MYB protein as a result of RAV integration within one c-myb allele.

truncated C-MYB protein

c-myb allele


Input: Frozen/thawed extensor digitorum longus muscle tendon units had significantly lower values for load to failure (p < 0. 01), energy absorbed to failure (p < 0. 01), and strain at failure (p < 0. 01), and they tended to fail at a different anatomic location (p < 0. 01) (broadly at the fascia-muscle interface as compared with horizontally at the musculotendinous junction) than fresh units.


Input: Northern analysis of the 3. 1-kb PWP2H cDNA revealed that a 3. 3-kb major transcript is ubiquitously expressed in human adult tissues.

3. 1-kb PWP2H cDNA


Input: Forty-eight 10-12-week-old male Sprague-Dawley rats were randomized to receive, daily for 28 days: (1) CsA vehicle p. o. plus FB vehicle sc; (2) CsA (15 mg/kg) p. o. plus FB vehicle sc, (3) CsA vehicle p. o. plus FB (1. 5 mg/kg) sc; and (4) CsA (15 mg/kg) p. o. plus FB (1. 5 mg/kg) sc.


Input: CsA alone resulted in elevated bone turnover.


Input: Individuals attending the GUM Department in the Royal Infirmary of Edinburgh between 1990 and 1994 with the diagnosis of HIV infection, genital warts, genital herpes, non-specific genital infection (NSGI), gonorrhoea and syphilis were included in the study.


Input: Northern blotting showed that MDMX, like MDM2, is expressed in all tissues tested, and that several mRNAs for MDMX can be detected.

MDMX

MDMX


Input: The nucleotide sequence of 22, 846 bp of the left arm of chromosome IV is described.


Input: Natural FL protein has been purified from a stromal cell line and shown to be a 65 kD nondisulfide-linked homodimeric glycoprotein comprised of 30 kD subunits, each containing 12 kD of N-and O-linked sugars.

FL protein


Input: The objective of this study was to examine the influence of HHCA and other serological factors upon the development of VGS.


Input: Spliced exons of adenovirus late RNAs colocalize with snRNP in a specific nuclear domain.


Input: Using Spurr' s resin as a mounting medium, we could observe thick specimens with oil immersion objective lens without the use of coverslips, then avoid air bubbles near the specimen.


Input: The present study investigated dose dependence and time course effects of the benzodiazepine (BDZ) partial inverse agonist, RO19-4603 (0. 005-0. 30 mg/kg) alone, and in combination with the BDZ receptor antagonists flumazenil, ZK 93426, and CGS 8216 (20 mg/kg) in selectively bred alcohol-preferring (P) rats provided a two-bottle choice test between ethanol (EtOH) (10% v/v), and a palatable saccharin (0. 0125% g/v) solution.

BDZ receptor


Input: Beyond the Tower of Babel: a nomenclature for suicidology.


Input: Infection with Neisseria meningitidis group B has been difficult to detect, partly because this bacterial group' s polysaccharide is a weak immunogen.


Input: Rss1p encodes a novel essential protein of 538 amino acids, which contains an extended predicted coiled-coil domain and is located both at nuclear pore complexes (NPCs) and in the cytoplasm.


Input: To map this regulatory serine phosphorylation site we developed a baculovirus-mediated expression system for wild-type annexin II and for a series of annexin II mutants which contained substitutions in one or more serine residues present in the N-terminal domain.

wild-type annexin II

annexin II mutants


Input: The PAI-2 gene is one of the most TNF-responsive genes known and is also highly induced by the phorbol ester phorbol 12-myristate 13-acetate (PMA) and the phosphatase inhibitor, okadaic acid, in both HT-1080 fibrosarcoma and U-937 histiocytic cells.

PAI-2 gene

TNF-responsive genes


Input: 220, 263-273).


Input: T., Patel, S.


Input: Growth factors induce the expression of the immediate early gene products MAP kinase phosphatase-1 (MKP-1), c-Fos and c-Jun.

immediate early gene products MAP kinase phosphatase-1

c-Fos

c-Jun


Input: The up-regulation of E-selectin, one of the adhesion molecules on the endothelium, is an important event in the mediation of the inflammatory response.

E-selectin


Input: The NIT2 protein is localised in nuclei and could not be detected in the cytoplasmic fraction of cells subjected to nitrogen derepression or nitrogen repression, indicating that the nuclear import of NIT2 is not regulated.

NIT2 protein


Input: In spite of much effort, no one has succeeded in isolating and characterizing the enzyme (s) responsible for synthesis of cellulose, the major cell wall polymer of plants.


Input: Vascular responses to reactive hyperemia (with flow increase leading to endothelium-dependent dilation) and to sublingual glyceryl trinitrate (GTN; endothelium-independent dilation) were recorded.


Input: During this period, administration of additional exogenous PRL did not stimulate further activation (binding) of the Stat factors.

exogenous PRL

Stat factors


Input: Intraperitoneal administration of L-5-hydroxytryptophan (L-5-HTP) at doses of 25 to 100 mg/kg dramatically increase defecation in mice.


Input: In the VA-SMV mode, the connection was made with valved conduits from the LV apex (inflow) to the ascending aorta (outflow) (n = 11) or to the DAo (n = 12).


Input: Factor V Leiden is a genetic disorder associated with an increased risk of venous thrombosis.


Input: This is the first determination of the complete secondary structure of an RNA spliced in a spliceosome.


Input: The majority of the cases with 0-I or 0-III components were sm. cancer.


Input: These patients appear to have slightly better pulmonary function and nutritional status; yet, they seem to have a higher degree of health care utilization.


Input: This observation calls for careful monitoring of calcium and alkaline phosphatase values and possible adjustments of vitamin D intake when fortifiers are used for extended periods.

alkaline phosphatase


Input: We have found that PEA2 is also required for the bipolar budding pattern and that it encodes a novel protein with a predicted coiled-coil domain.


Input: Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway.

small GTP-binding proteins Rac1

c-Jun N-terminal kinase

stress-activated protein kinase


Input: Percent identities of the mouse PP2 to mouse Y1, mouse Y4/PP1 and human Y2 receptors are 53, 42, and 31, respectively.

mouse PP2

mouse Y1

human Y2 receptors


Input: Correlating with the previous observation that CBF binding to the 78C1 site is enhanced by EGTA and EDTA, these divalent cation chelators specifically stimulate 78C1-directed transcription.

CBF


Input: The human gene fragment ligated to the minimal rat liver glucokinase promoter was shown to work as an enhancer in the hepatocyte transfection system.

glucokinase


Input: To test the role of ML in human reproductive axis, 128 healthy children, 68 boys and 60 girls, were studied.


Input: However, the truncated deer receptor lacks the most C-terminal tyrosine residue in the intracellular domain which is believed to be essential for activation of the beta-casein promoter.

deer receptor

beta-casein promoter


Input: This report provides further evidence for the riMLF in the control of downgaze, and a synkinesis is postulated for the development of the convergence retraction nystagmus.


Input: Ninety-four percent of the EPs were tubal, and 90% of the tubes exhibited some pathologic changes, including chronic salpingitis (49. 5%) and follicular salpingitis (10%), among others.


Input: The assessment using 7 H 9 liquid medium by the former author demonstrated the potent activities of both CS-940 * and sparfloxacin (SPFX), followed by AM-1155 *, ciprofloxacin (CPFX), levofloxacin (LVFX), OPC-17116 *, NM-394 * in sequence.


Input: The STE20 gene, encoding a protein kinase required for pheromone signal transduction, has recently been identified in a genetic screen for high-gene-dosage suppressors of a partly defective G beta mutation.

STE20 gene

G beta


Input: This enzyme is designated (1--> 4)-beta-xylan endohydrolase isoenzyme X-I.

(1--> 4)-beta-xylan endohydrolase isoenzyme X-I


Input: Magnetic resonance imaging in coccidioidal arthritis.


Input: Moloney murine leukemia virus (MMLV)-derived pUCMoTiN-based retroviral vectors were engineered to allow constitutive and Tat (trans-activator of transcription)-inducible expression of five hammerhead ribozymes targeted against highly conserved sequences within the group antigen (Gag), protease (Pro), reverse transcriptase (RT), tat, and envelope (Env) coding regions of human immunodeficiency virus type-1 (HIV-1) RNA.

Tat

trans-activator of transcription

group antigen

Gag

protease

Pro

reverse transcriptase

RT

tat

envelope

Env


Input: REM sleep deprivation was performed using the platform technique.


Input: The same ligands also exhibit a similar inhibitory effect on PDGF-BB-dependent [3H] thymidine incorporation in PAE cells expressing the PDGF beta-receptors.

PDGF-BB

PDGF beta-receptors


Input: We analyzed serial biopsy specimens from eight patients with FL for secondary alterations of the rearranged bcl-2 gene in the breakpoint and open reading frame (ORF) regions.

rearranged bcl-2 gene


Input: In all eight cases, neither FL nor DLL cells showed alterations of bcl-2 gene sequences in the breakpoint region, suggesting high conservation of the bcl-2 gene during both t (14; 18) translocation and morphologic transformation of the FL cells.

bcl-2 gene sequences

bcl-2 gene


Input: BACKGROUND: The Bazett-corrected QT (QTc) interval during exercise has been used as a marker for ischemic disease, arrhythmogenic substrate and the long QT syndrome.


Input: An essential role of c-Jun and c-Fos in basal and PMA-stimulated transcription of the PAI-1 gene is demonstrated by our finding that antisense c-jun and c-fos oligodeoxynucleotides both strongly reduced basal and PMA-stimulated PAI-1 synthesis.

c-Jun

c-Fos

PAI-1 gene

c-jun

c-fos


Input: To analyze the mechanism of fos/jun activation by TCDD we have used electrophoretic mobility shift and transient expression assays of reporter gene constructs containing response elements for 12-O-tetradecanoyl-phorbol-13-acetate (TRE), serum (SRE), cAMP (CRE), and aromatic hydrocarbons (AhRE) from the fos and jun genes fused to the firefly luciferase gene under the control of the SV40 minimal promoter.

fos

jun

fos

jun genes

firefly luciferase gene

SV40 minimal promoter


Input: The optimal sequence for interaction with mu 2 and with AP-2 has tyrosine as an anchor and prefers arginine at position Y + 2 and leucine at position Y + 3.

mu 2


Input: STK/RON-expressing Ba/F3 pro-B cells (BaF/STK) exhibited MSP-dependent growth, whereas STK/RON-expressing mouse erythroleukaemia cells (MEL/STK) displayed MSP-induced apoptosis.

STK

RON

STK

MSP

STK

RON

STK

MSP


Input: In vitro DNase I footprinting showed that OxyR-C199S protected Pmom from-104 to-46 on the top strand and produced a protection pattern characteristic of reduced wild-type OxyR.

DNase I

Pmom

reduced wild-type OxyR


Input: Kss1 binds specifically to a GST-Dig1 fusion in the absence of any other yeast protein.

GST


Input: In contrast, dig1 dig2 cells constitutively invade agar medium, whereas a dig1 dig2 ste12 triple mutant does not, indicating that Dig1 and Dig2 share a role in negatively regulating the invasive growth pathway.

dig1 dig2

dig1 dig2 ste12


Input: Comparison of the sequences of the xFxFG repeat regions of p62 and Nsplp indicated that NTF2 was probably interacting with the phenylalanine-containing core of these repeats and not the intervening hydrophilic linkers.

Nsplp


Input: This is the first report of the successful resection of a MFH originating in the renal capsular tissue and extending into the inferior vena cava.


Input: Transient expression of VSF-1 in protoplasts stimulated vs-1 dependent activation of the-76/grp1. 8 minimal promoter.

-76/grp1. 8 minimal promoter


Input: Keeping in mind the limited range of age and dosages, advantages and disadvantages of the drug are discussed, comparing the experimental results with those derived from the literature.


Input: Blood sampling procedures were videotaped.


Input: Analysis of one cDNA revealed an unusual splicing event involving EZH1 and a tandemly linked gene GPR2 and suggests a potential mechanism for modifying the EZH1 protein in the conserved C-terminal domain.

EZH1 protein


Input: A given standard input function and a given value of distribution volume (Vd) used for the rCBF measurement of this method were calculated from the dynamic study by six normal volunteers.


Input: They lack a predicted single stranded (ss) DNA binding motif that is unique the large terminase proteins in T4 gp17, and that has been implicated in recognizing ssDNA regions in replicating and recombining T4DNA destined to be packaged.

terminase proteins

T4 gp17


Input: It can be concluded that in normotensive subjects, uric acid and xanthine oxidase have significant association with blood pressure and thus are one of the many factors which are involved in the cause or effect of hypertension.

xanthine oxidase


Input: Immunoblotting of expressed recombinant proteins with the monoclonal 08L antibody localized the 08L epitope to the carboxyl end of the protein.

monoclonal 08L antibody


Input: We infer that the dominant negative inhibition results from both direct proteolysis of the beta-galactosidase tetramer by the fusion subunit and detour of the tetramer to the lysosome.

beta-galactosidase tetramer


Input: The current study defines the vinculin-and FAK-interaction domains on paxillin and identifies the principal paxillin focal adhesion targeting motif.

vinculin

FAK-interaction domains

paxillin

paxillin


Input: These data demonstrate the presence of a single binding site for vinculin, and at least two binding sites for FAK that are separated by an intervening stretch of 100 amino acids.

vinculin

FAK


Input: These data demonstrate that paxillin localizes to focal adhesions independent of interactions with vinculin and/or FAK, and represents the first definitive demonstration of LIM domains functioning as a primary determinant of protein subcellular localization to focal adhesions.

paxillin

vinculin

FAK

LIM domains


Input: A single protease-resistant structure formed by the entirety of both PDZ repeats 1 and 2 (PDZ1-2) contains the protein 4. 1-binding site.

PDZ repeats 1 and 2

protein 4. 1-binding site


Input: Several agents have been tried for treatment, often limited by toxic side effects.


Input: Jerseys had higher hepatic Cu concentrations than did Holsteins on d 60 (346 vs.


Input: These results are consistent with the well established polarity of RXR heterodimer binding to bipartite hormone response elements, with the VDR recognizing the 3'-half-element.

RXR

VDR


Input: PPAR gamma mRNA levels were reduced by 95% with 3 nM TNF alpha treatment for 24 h.

PPAR gamma mRNA

TNF alpha


Input: Exons III to VIII, which cover the coding region and the 3' untranslated region, are almost identical in all types of PST or AST cDNAs.

PST

AST cDNAs


Input: Growth factor allows effective dose-intensive regimen in advanced breast cancer patients.


Input: Recombinant erythropoietin (r-HuEPO) in the treatment of anemia in multiple myeloma

Recombinant erythropoietin

r-HuEPO


Input: In 1993 and 1994 and infection with body lice was registered 41 times in 31 patients at the clinic for homeless of the Community Health Service of Utrecht.


Input: Ki-ras and p53 mutations in pancreatic ductal adenocarcinoma.

Ki-ras

p53 mutations


Input: Epidemiological data are quite controversial but sudden death occurring during sporting activity is probably not a rare occurrence.


Input: However, the ratio M/Pc provides a useful index that seems to be independent of the metabolic demand.


Input: Rat liver catalase is sorted to peroxisomes by its C-terminal tripeptide Ala-Asn-Leu, not by the internal Ser-Lys-Leu motif.

Rat liver catalase


Input: These data provide strong evidence that E2F or an E2F-related transcription factor is involved in the regulation of nonmuscle myosin expression.

E2F-related transcription factor

nonmuscle myosin


Input: When the E1A N-terminus is used as a competitor in squelshing experiments it abolishes CBP-induced activation of E2F1/DP1, whereas an E1A mutant lacking CBP binding ability fails to do so.

E1A N-terminus

CBP

E1A mutant

CBP


Input: Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1.

Maf proteins


Input: On the third occasion water (W) was ingested throughout the run.


Input: The effect of maternal ingestion of the reduced energy sweetener erythritol was investigated in KBL: JW strain pregnant rabbits.


Input: The nm23-H1/nm23-H2 gene transcriptional activity ratio varied depending on the cell line.


Input: CONCLUSION: Intravenous diazepam administration before EGD produces a significant fall in SpO2 during the procedure, and so should be avoided; continuous monitoring of SpO2 should be done during EGD.


Input: The nucleotide sequence alignment between mouse and human CA IV shows 69% identity in the coding region and all of the exon-intron boundaries are conserved, as are the sizes of the introns.

human CA IV


Input: Discordance on the cost dimension correlated negatively with G Hb, suggesting better glycemic control with greater disagreement.

G Hb


Input: DATA SOURCES: Epidemiologic studies, research studies, review articles, and government reports pertaining to epidemiology of lung cancer.


Input: Histological changes, including cortical cell involution and hemorrhage occurring during the neonatal period, would seem to have crucial relevance to the remodeling of the adrenal vasculature.


Input: Furthermore, co-expression of both p46 and p54 subunits markedly altered the subcellular distribution of p46; co-expressed p46 was transported into the nucleus as efficiently as p54.

p54 subunits


Input: The results suggest that, although both the N-and C-terminal regions of talin bind actin, the properties of these two regions of the protein are distinct.

talin

actin


Input: Merr.) embryo library.


Input: The accumulation of both LHA4 and LHA2 mRNAs is induced by the addition of exogenous sugars and this induction appears to be dependent on sugar uptake and metabolism, because mannitol and 3-O-methylglucose do not stimulate mRNA accumulation.

LHA2 mRNAs


Input: Using the yeast one-hybrid screen with integrated NRE and flanking DNA as bait, the predominant clone obtained was bovine Nrl.

bovine Nrl


Input: As the rate of protein synthesis decreases during late embryogenesis, levels of SEC-1 and its cognate mRNA decline precipitously.


Input: These findings suggest that fodrin proteolysis in vivo may reflect the activity of multiple ICE/Ced-3 proteases whose partial sensitivity to DEVD-CHO reflects a limited contribution from CPP32, or an ICE/Ced-3 protease less sensitive than CPP32 to DEVD-CHO inhibition.

fodrin

ICE

ICE


Input: In 3Y1 and 3Y1 v-crk-transformed fibroblasts, almost all of the total PTP1B and about 40% of total p130 (Cas) co-sediment with membranes composed primarily of endoplasmic reticulum.

v-crk

Cas


Input: Replacing residues 405-419 on delta419 with the conserved AF-2 domain from the vitamin D3 receptor or the estrogen receptor results in a receptor with wild-type or low transcriptional activity, respectively.

vitamin D3 receptor

estrogen receptor


Input: Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines.

SREBP cleavage-activating protein


Input: The Escherichia coli tet-repressor (TetR) operator system was used to develop a variation of the yeast two-hybrid assay in which disruptions of protein-protein interactions can be identified by a positive selection.

Escherichia coli tet-repressor

TetR


Input: Recent studies have suggested that SHP-1 regulates the function of Jak family tyrosine kinases, as shown by its constitutive association with the Tyk2 kinase and the hyperphosphorylation of Jak kinases in the motheaten cells that lack functional SHP-1.

Jak

tyrosine kinases

Tyk2 kinase

Jak kinases


Input: Administration of a second dose of vaccine during the outbreak was not protective.


Input: But, as Theriault explains, improvements in assessing exposure have not yet translated into clear and consistent findings.


Input: Biol.


Input: Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation.

human lymphocyte kinase Lck


Input: Evolutive morphology of the olfactory bulb in man and certain non-human mammals


Input: From these results, we concluded that this ORF is the FRDS gene.

FRDS gene


Input: FK506 is 10-to 100-fold more potent than cyclosporin A in preventing organ rejection and in toxicity.


Input: These results suggest that Rho1p regulates cytoskeletal reorganization at least through Bni1p and Pkc1p.


Input: Waves N1, P3 and CNV were recorded during a CNV paradigm in a simple reaction time task with a constant interstimulus interval (ISI) of 1 sec.


Input: Therefore, both the Chilean and the Japanese samples collected in high-risk areas showed higher mutagenic rates than the Japanese ones in a low-risk area, with a statistical significance (p < 0. 001), chi-square test).


Input: Regulation of ASN1 and ASN2 expression was studied using lacZ fusions and both genes were found to be several times less expressed in the absence of the transcription activator Gcn4p.

lacZ fusions


Input: Several particular features of this polypeptide fragment from the hamster lysyl-tRNA synthetase suggest that it is implicated in the assembly of that enzyme within the multisynthetase complex.

hamster lysyl-tRNA synthetase


Input: He is well, five years after relapse.


Input: Comparison of the proportion of nonsynonymous (pN) and synonymous (pS) substitutions occurring per site within tamarin variable region genes demonstrated a reduction in pN in the framework regions compared with pN in the presumed MHC contact regions (CDR1 and CDR2).

tamarin variable region genes

MHC contact regions


Input: The effects of oral vanadyl sulfate (VOSO4) (0. 5 mg/kg/day) on anthropometry, body composition, and performance were investigated in a 12-week, double-blind, placebo-controlled trial involving weight-training volunteers.


Input: Later in development, Tbx6 expression is restricted to presomitic, paraxial mesoderm and to the tail bud, which replaces the streak as the source of mesoderm.


Input: Disruption of re-replication control by overexpression of human ORC1 in fission yeast.

human ORC1


Input: Our results demonstrate that the promoter and enhancer regions identified here are essential for maintaining the efficient promoter activity of the human activin betaA subunit gene.

human activin betaA subunit gene


Input: Recombinant, bacterially expressed PIP5KIalpha possessed PIP5K activity and was immunoreactive with erythroid PIP5KI antibodies.

erythroid PIP5KI antibodies


Input: Human acid ceramidase ((AC) N-acylsphingosine amidohydrolase, EC 3. 5.

Human acid ceramidase

(AC) N-acylsphingosine amidohydrolase

EC 3. 5


Input: The 0. 22-kb NheI/BglII promoter exhibited PMA inducibility in myeloid cells and contained a PMA-responsive element recognized by Sp1 and EGR-1 transcription factors.

NheI

BglII

EGR-1 transcription factors


Input: Northern (RNA) blot analyses indicated that the cdh genes encoding the five subunits and an open reading frame (ORF1) with unknown function are cotranscribed during growth on acetate.

cdh genes


Input: Two classes of mutations were obtained: (i) those that altered the coding region of HOL1, conferring the ability to take up histidinol; and (ii) cis-acting mutations (selected in a mutant HOL1-1 background) that increased expression of the Hol1 protein.

Hol1 protein


Input: Damage to the BBB was judged by extravasation of Evans Blue (EB) dye, which was administered either 2, 3, 24 or 48 h after onset of MCAo.


Input: Lipid hydroperoxide levels in plasma and LDL remained unchanged throughout the study.

LDL


Input: We report a case of vasculitis (cutaneous and neurologic) which led to the discovery of a selective immunodeficit towards EBV, similar to Purtilo' s syndrome.


Input: To elucidate whether potential endocrine changes resulted from acute hypoxaemia alone, the underlying disease, or unspecific influences connected with the ICU setting, all measurements were compared to those of a completely healthy reference group (REF) with comparable acute experimental hypoxaemia.


Input: There were no significant differences in graft survival between groups with early graft function (EGF) and DGF, either in first transplantations or retransplantations.


Input: These results suggested that the GG motifs contributed to the cell-specific transcription of the human insulin gene in association with the binding of the sequence-specific nuclear factor.

human insulin gene


Input: Abnormal urinary coproporphyrin levels in patients infected by hepatitis C virus with or without human immunodeficiency virus.


Input: The determination of immunoglobulin E (IgE) antibodies by one of several laboratory tests, by skin-prick tests or by appropriate challenge procedures is useful either to identify atopic individuals or as outcome predictors in wheezy children.

immunoglobulin E

IgE


Input: Thrombosis of the renal vein may be dramatic and include renal failure.


Input: Filter and cytocentrifuge preparations of the urine were studied and all cases displayed numerous scattered aggregates or single tumor cells in an inflammatory background.


Input: The promoter segment was inactive when introduced into the rat glioma cell line C6B4, the rat submandibular cell line RSMT-A5, and the rat pancreatic beta cell line RIN-5AH, all of which do not express the endogenous alpha2c-AR gene.

alpha2c-AR gene


Input: The sequencing of the conditional lethal mutation ts-A13, localized in the nrdE cistron, and the lethality of insertional mutations targeted in the internal region of nrdE and nrdF, demonstrated the essential role of this locus.

nrdE cistron

nrdE

nrdF


Input: The microdensitometric scores and their side-to-side differences in patients correlated negatively with the serum 25-OHD concentration and positively with the degree of paralysis.


Input: These data do not support the use of LDD to reduce risk of progression to MSOF in sepsis.


Input: This correlated with reduced levels of secreted hepatitis B e antigen and increased intracellular levels of core and Pol proteins and replicative HBV DNA intermediates.

hepatitis B e antigen

core

Pol proteins


Input: In contrast, extracts of the mutant virions catalyze the wild-type level of transcription from an exogenous template containing an early promoter.


Input: The SCMV SNE sites contain potential overlapping core recognition binding motifs for SRF, Rel/NFkappaB, ETS, and YY1 class transcription factors but fail to respond to either serum or tumor necrosis factor alpha.

SCMV SNE sites

SRF

Rel

NFkappaB

ETS

YY1 class transcription factors

tumor necrosis factor alpha


Input: Upon serum withdrawal at the permissive temperature, p53-mediated apoptosis was induced in 50 to 60% of the cells.


Input: To circumvent this problem, a simple two-step strategy was devised by which essential cis-acting sites like the a sequence can be readily deleted from their natural loci in large viral DNA genomes.


Input: On the basis of serological studies, the highly conserved A domain of HspA was found to be the immunodominant domain.

HspA


Input: In Group IV dogs that received alpha-MSH only during reperfusion, BAEPs were increased approximately 10 to 14% more than in Group II during the late reperfusion period.

alpha-MSH


Input: The Fas receptor mediates a signalling cascade resulting in programmed cell death (apoptosis) within hours of receptor cross-linking.

Fas receptor


Input: Fas has been shown to require ICE (interleukin-1 beta-converting enzyme) family proteases to induce apoptosis from studies utilizing the cowpox ICE inhibitor protein CrmA, the synthetic tetrapeptide ICE inhibitor YVAD-CMK, and the tripeptide pan-ICE inhibitor Z-VAD-FMK.

Fas

ICE

interleukin-1 beta-converting enzyme

ICE inhibitor protein CrmA

ICE

YVAD-CMK

ICE

Z-VAD-FMK


Input: The imprinted expression of the endogenous gene can be recapitulated in mice by using a 14-kb transgene encompassing 4 kb of 5'-flanking sequence, 8 kb of 3'-flanking sequence, which includes the two endoderm-specific enhancers, and an internally deleted structural gene.


Input: In this report, we demonstrate that hGCN5 is also an HAT and has the same substrate specificity as yGCN5.

HAT


Input: Complementary DNAs encompassing the coat protein coding and adjacent regions of Agropyron mosaic virus (AgMV) and Hordeum mosaic virus (HoMV) were cloned and sequenced.

coat protein


Input: In some cases, factor-induced Rac activation results in Rho activation, and factor-induced Cdc42 activation leads to Rac activation, as determined by specific morphological changes.

Rac

Rho

Rac


Input: Several cDNAs corresponding to the human PWP2 gene were identified and partially sequenced.

human PWP2 gene


Input: Isolation and genomic structure of a human homolog of the yeast periodic tryptophan protein 2 (PWP2) gene mapping to 21q22. 3.

yeast periodic tryptophan protein 2


Input: Patterns defined by combinations of normal and abnormal laboratory results had decreased the likelihood of PEM from an all-2 to all-0 pattern.


Input: To examine whether thiamine (vitamin B1) deficiency is associated with recurrent aphthous stomatitis, we studied vitamin B1 levels in 70 patients with recurrent aphthous stomatitis and in 50 members of a control group.


Input: Liver injuries


Input: By screening a cDNA library with a probe derived from sequences downstream of the p53p2 start site, we have cloned and characterized a cDNA that represents a mRNA that appears to have been initiated from the p53p2 promoter.

p53p2 promoter


Input: However, we did not observe a correlation between serum and seminal plasma PSA levels.

seminal plasma PSA


Input: The implications for estimates of cortical magnification and possible differences in the specializations of foveal and peripheral vision are discussed.


Input: G-CSF activates multiple signaling molecules, including the JAK1 and JAK2 kinases and the STAT transcription factors.

G-CSF

JAK2 kinases

STAT


Input: Mutants lacking any tyrosine residues in the cytoplasmic domain maintain their ability to activate STAT5 and STAT1 but cannot activate STAT3, implying that STAT5 and STAT1 activation does not require receptor tyrosine phosphorylation.


Input: In addition, double mutants with either dim1-delta or dim2-1 and the endocytosis mutants end4-1 or act1-1 displayed synthetic growth defects, indicating that the DIM gene products function in a common or parallel endocytic pathway.

mutants end4-1

DIM gene products


Input: Such multisensory interactions can be significant for behavior.


Input: The P13 and N22 of ppSEPs had phase reversal relationship with the P2 and N2 recorded from the PES, respectively.


Input: The cDNA of cpm7 encodes a closely related protein of 36. 8 kDa.


Input: Finally, the C-terminal region of ENBP1 shows strong homology to a protein from rat that is specifically expressed in testis tissue.


Input: The conservation of both the G-box and H-box in different CHS promoters emphasizes their importance as regulatory motifs.

CHS promoters


Input: Mortality on the last ranch was particularly severe among certain segregated groups of turkeys that included toms, heavier birds, and birds undergoing a stressful event such as artificial insemination.


Input: Further, the PIP2 content of the 85-90 kDa protein appeared to decrease with CSF-1 treatment.


Input: Further, the PIP2 content of the 85-90 kDa protein appeared to decrease with CSF-1 treatment.


Input: Just before inserting on the anterior margin and apex of the iliac crest it widens, assuming the aspect of a small cone.


Input: Reperfusion caused a transient reduction in lactate production and a significant increase in LDH release.

LDH


Input: To evaluate the hepatic regenerative response in patients with alcoholic liver disease, sera from 263 patients with severe alcoholic hepatitis and/or cirrhosis were analyzed for hepatocyte growth factor (HGF) and alpha-fetoprotein (AFP).

hepatocyte growth factor

HGF

alpha-fetoprotein

AFP


Input: Children born from chronic alcoholic mothers have shown behavioral teratogenic effects more frequently than morphological malformations.


Input: INTERVENTION (S): Twenty-six hemostasis parameters evaluated repeatedly in patients undergoing IVF-ET.


Input: Here we report that expression of the I-POU/tI-POU message is maximal late in the embryonic phase of Drosophila development, and I-POU is the preferred splice variant.

I-POU

tI-POU

I-POU


Input: The patient' s role, organized by the prerequisites of expressive freedom, is counter posed with the psychoanalyst' s, which is structured to empower listening and understanding.


Input: The most common risk factor reported for both recent and all other hepatitis C cases was a history of injecting drug use, although the proportion of cases with that history was different in NT from ACT and Queensland.


Input: Silencing can be restored by creation of a telomere at 13 kb from the reporter construct, or by insertion of 340 bp of yeast telomeric repeat sequence at this site without chromosomal truncation.


Input: In contrast with previous two-pool models, provisions were made for folate turnover by urinary folate excretion (as measured here) and by fecal excretion and catabolic processes.


Input: When voltage-operated Ca2 + channels (VOC) were blocked by nifedipine, midazolam, in concentrations more than 1 microM, attenuated both phasic and tonic responses.


Input: Although p48 gene induction is dependent on STAT1 and JAK1, activated STAT1 does not bind to GATE.

p48 gene

GATE


Input: The syndrome of resistance to thyroid hormone is characterized by elevated serum free thyroid hormones, failure to suppress pituitary thyrotropin secretion, and variable peripheral refractoriness to hormone action.

pituitary thyrotropin


Input: Finally, nonphotosynthetic mutants, including the tscA-lacking photosystem I mutant, H13, did not show evidence of light-stimulated RNA processing.

tscA-lacking photosystem I mutant


Input: The progression of acute bronchitis is associated with elevated blood concentrations of acute-phase proteins, KKS activation in the blood and high serotonin and lactic acid content in the humor condensated from the exhaled air.

KKS


Input: Because of the potential implications of these findings in human physiology, we cloned the hPACAP-R gene.

hPACAP-R gene


Input: Differential signaling and immediate-early gene activation by four splice variants of the human pituitary adenylate cyclase-activating polypeptide receptor (hPACAP-R).

immediate-early gene

human pituitary adenylate cyclase-activating polypeptide receptor

hPACAP-R


Input: We discuss these results with respect to the transcriptional induction of the HNF-3 alpha gene in respiratory epithelium during embryogenesis.

HNF-3 alpha gene


Input: BACKGROUND: Mitosis is regulated by MPF (maturation promoting factor), the active form of Cdc2/28-cyclin B complexes.

MPF

maturation promoting factor

cyclin B


Input: Ectopic expression of Apo-3 in HEK293 or HeLa cells induced marked apoptosis.


Input: An N-terminal arm from each subunit wraps around the dinucleotide-binding domain of an adjacent subunit, covering the adenine ring of NADP.


Input: Similarity is most striking in the zinc knuckle region, a region characteristic of gag genes of most replication-competent retroelements.

gag genes


Input: D. melanogaster HeT-A coding sequences have a polymorphic region with insertions/deletions of 1-31 codons and many nucleotide changes.

HeT-A


Input: Eukaryotic initiation factor 3 (eIF3) is a large multisubunit complex that stabilizes the ternary complex, eIF2 x GTP x tRNA (Met) i and promotes mRNA binding to the 40 S ribosomal subunit. eIF3 also functions as a ribosome subunit anti-association factor.

Eukaryotic initiation factor 3

tRNA (Met) i

40 S ribosomal subunit


Input: Our data, combined with those of Hershey and co-workers, suggest that mammalian eIF3 is composed of at least 10 subunits: p170, p116 (hPrt1), p110, p66, p48, p47, p44, p40, p36, and p35.

mammalian eIF3


Input: Identification of a cis-acting element in the class I major histocompatibility complex gene promoter responsive to activation by retroviral sequences.

class I major histocompatibility complex gene promoter


Input: The results demonstrate that (i) no intact capsids were assembled when the full-length or a truncated (missing the C-terminal 65 amino acids) UL80. 5 protein was tested; (ii) when the C-terminal 65 amino acids of the UL80. 5 protein were replaced with the C-terminal 25 amino acids of the UL26. 5 protein, intact capsids were made and direct interaction of the UL80. 5 protein with VP5 was detected; (iii) assembly of intact capsids was demonstrated when the sequence of the last 12 amino acids of the UL80. 5 protein was changed from RRIFVA ALNKLE to RRIFVAAMMKLE; (iv) self-interaction of the scaffold proteins is mediated by sequences N terminal to the maturation cleavage site; and (v) the UL26. 5 and UL80. 5 proteins will not coassemble into scaffold structures.

UL80. 5 protein

UL80. 5 protein

UL26. 5 protein

UL80. 5 protein

UL80. 5 protein

UL26. 5

UL80. 5 proteins


Input: Fourth, the 3'-region splice junctions of the MSRs during latent and productive infection were determined by sequencing RNA-PCR products generated with primers that flank the 3' splice region.

MSRs


Input: (ii) ICP27 binds preferentially to less modified forms of ICP4, a protein that is extensively modified posttranslationally.


Input: Lack of sufficient data on vibration measurements and employment durations add to the uncertainty, as do variations in tool conditions (grinder wheels, etc) and inherent difficulties in measurement.


Input: C/EBP beta V > A selectively binds only the subset of C/EBP sites that are also DBP sites, both as oligonucleotides and within the natural contexts of the albumin and cholesterol hydroxylase promoters.

C/EBP beta V

C/EBP sites

DBP sites

albumin

cholesterol hydroxylase promoters


Input: Specific IgG, specific IgE and total IgE immunoglobulins against Toxocara canis excretory/secretory antigens (TES) were detected by using ELISA technique.

IgG

IgE

IgE immunoglobulins

Toxocara canis excretory/secretory antigens

TES


Input: SUMMARY BACKGROUND DATA: Melanoma care has not changed significantly in the last 20 years, and the controversy of elective lymph node dissections in this disease continues to be discussed.


Input: The differences among subgenera of the genus Dermacentor are more significant.


Input: Mutating the E-box in the context of the 3'-flanking region confirmed that it contributes to the enhancement of transcriptional activity of the alpha1 (I) collagen gene promoter.

alpha1 (I) collagen gene promoter


Input: Expression of neuronal traits in pancreatic beta cells.


Input: We propose that Mnt: Max: Sin3 complexes normally function to restrict Myc: Max activities associated with cell proliferation.

Mnt

Max

Myc

Max


Input: Phenotypic changes induced by wild type and variant c-src genes carrying C-terminal sequence alterations.

wild type and variant c-src genes


Input: The resurgence of drug-resistant malaria makes urgent the evaluation of new antimalarial agents.


Input: In the p51 subunit, the Cys181 side-chain is oriented in a similar direction to the Tyr181 side-chain in the wild-type complex.

p51 subunit


Input: The relatively high level transcription from this gene shows that the polymorphic chromosome ends of P. falciparum, which have been proposed to be transcriptionally silent, can be active expression sites for var genes.

var genes


Input: NUP145 was previously identified by using a genetic synthetic lethal screen (E.


Input: Prevalence of sleep-disordered breathing (SDB) is reported to increase in menopausal women.


Input: In all cases the antigenemia was transient and cleared by 28th day post-vaccination.


Input: A total of 1459 men aged 48 to 84 years, who were diagnosed for the first time by physicians as having BPH in 1994 and who had not received treatment, participated in the study.


Input: In vitro translation of the mTRF1 cDNA resulted in a 56 kDa protein that binds to TTAGGG repeat arrays. mTRF1 displayed the same sequence specificity as hTRF1, preferring arrays of TTAGGG repeats as a binding substrate over TTAGGC and TTGGGG repeats.

mTRF1 cDNA


Input: The ubiquitously expressed E12 bHLH protein dimerizes with numerous cell-specific bHLH factors.

E12 bHLH protein

bHLH factors


Input: The E-box sequence in the SE2 fragment of the transferrin promoter was CATCTG and was similar in gel shifts to the consensus E-box elements (CANNTG) previously characterized.

SE2 fragment

transferrin promoter


Input: A 5. 3-kb DNA fragment, which included the entire structural porin gene (named porCa) and its flanking regions, was identified.

porin gene

porCa


Input: The human p100 protein was recently identified as a coactivator of the Epstein-Barr virus nuclear antigen 2.

human p100 protein

Epstein-Barr virus nuclear antigen 2


Input: However, five new mutation sites (S61, SL1, S29, SL11, SL196 and SL126) are unique to the nrdB intron and disrupt self-splicing.

nrdB


Input: This report presents the isolation and characterization of the 5'-flanking region (1. 2 kb) and exon 1 of the human RII alpha gene.

human RII alpha gene


Input: A cohort of Swedish children was monitored from 6 months to 11 years of age.


Input: The aim of this study was to assess the reproducibility of a number of simplified clearance methods using chromium-51 ethylenediamine tetraacetic acid (51Cr-EDTA) and to compare these with the multiple blood sample technique.


Input: The primary structure of a 2671 bp DNA fragment between the pla gene (encoding plasminogen activator) and the origin of replication of the wild-type Yersinia pestis plasmid pYP358 was determined.

pla gene

plasminogen activator


Input: MAIN OUTCOME MEASURES: Associations of factor analysis-derived syndromes with risk factors for chemical interactions that inhibit butyrylcholinesterase and neuropathy target esterase.

butyrylcholinesterase

esterase


Input: CONCLUSION: Some Gulf War veterans may have delayed, chronic neurotoxic syndromes from wartime exposure to combinations of chemicals that inhibit butyrylcholinesterase and neuropathy target esterase.

butyrylcholinesterase

neuropathy target esterase


Input: No correlation between the age of the horses and the antibody level could be found.


Input: The GHR mRNA: GHBP mRNA ratio was 1. 1 +/-0. 12 and remained unchanged during differentiation.

GHR mRNA

GHBP mRNA


Input: The results demonstrate (i) that the selenocysteine-specific UGA codon is readily suppressed under conditions where the homologous SelB protein is absent and (ii) that apart from the specificity of the SelB-mRNA interaction, a structural compatibility of the quaternary complex with the ribosome is required.

homologous SelB protein

SelB-mRNA


Input: One linker-peptide insertion in the RsaA C terminus (amino acid 784) had no effect on S-layer biogenesis, while another (amino acid 907) disrupted secretion of the protein, suggesting that RsaA possesses a secretion signal lying C terminal to amino acid 784, near or including amino acid 907.

RsaA C terminus (amino acid 784)

RsaA


Input: To characterize the gene products, the cvaA gene was subcloned and expressed under the control of T7 RNA polymerase promoter.

cvaA gene

T7 RNA polymerase promoter


Input: PrpB showed homology to carboxyphosphonoenolpyruvate phosphonomutase of Streptomyces hygroscopicus and to its homolog in the carnation Dianthus caryophyllus; PrpC was homologous to both archaeal and bacterial citrate synthases; PrpD showed homology to yeast and Bacillus subtilis proteins of unknown function; PrpE showed homology to acetyl coenzyme A synthetases.

PrpB

carboxyphosphonoenolpyruvate phosphonomutase of Streptomyces hygroscopicus

PrpC

archaeal and bacterial citrate synthases

PrpD

PrpE

acetyl coenzyme A synthetases


Input: MAIN OUTCOME MEASURES: Systemic and pulmonary hemodynamics, arterial blood gas determination, bronchoalveolar lavage protein and neutrophil content, neutrophil oxidant burst, lung myeloperoxidase content, and scanning electron micrographic studies.

lung myeloperoxidase


Input: We have isolated a cDNA encoding human MEKK3.

human MEKK3


Input: To investigate the mechanisms involved in the transcriptional control of retinoid X receptor (RXR) gene expression, the 5'-flanking region of the human RXRgamma2 isoform was characterized.

retinoid X receptor

RXR

human RXRgamma2 isoform


Input: JNK and p38 are constitutively present in the nucleus, and DNA-bound c-JUN and ATF-2 are stably contacted by JNK and p38, respectively.

JNK

c-JUN

JNK


Input: The effects of dominant interfering forms of the JNK/p38 signaling pathway demonstrate that activation of these kinases is critical for cytokine-induced E-selectin gene expression.

JNK

E-selectin gene


Input: Sp1 binds the CTC repeat with an affinity, KD = 0. 37 nM, at least as high as the consensus GC box.


Input: Identification of the region in actin-binding protein that binds to the cytoplasmic domain of glycoprotein IBalpha.

actin-binding protein

glycoprotein IBalpha


Input: Mutant enzyme forms were prepared to eliminate the initial autoprocessing site and thus form an active single-chain protein for structure-function studies.


Input: The primer is generated by a cleavage that occurs between bases 11 and 12 of the Tf1 mRNA.

Tf1 mRNA


Input: Similarly, we examined whether the ELK1, SAP1a, FLI1, EWS-FLI1, ETS1, ETS2, PEA3 and PU. 1 proteins can form ternary complexes with SRF on the Egr1 SREI and II.

EWS

PU. 1 proteins

SRF

Egr1 SREI and II


Input: This R-domain may modulate the interaction with SRF, providing a mechanism that would be unique to FLI1 and EWS-FLI1, thus implicating a novel function for these ETS transcription factors in the regulation of the Egr1 gene.

SRF

EWS

ETS transcription factors

Egr1 gene


Input: The murine chromosomal locations of the five NMDA receptor channel subunits, the epsilon 1 (Grin2a), epsilon 2 (Grin2b), epsilon 3 (Grin2c), epsilon 4 (Grin2d) and zeta 1 (Grinl) subunits, were determined using an interspecific backcross mapping panel derived from crosses of [(C57BL/6JxM. spretus) F1xC57BL/6J] mice.

NMDA receptor channel subunits

epsilon 1

epsilon 2

epsilon 3

epsilon 4

zeta 1

Grinl


Input: CDNA cloning of chick brain alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors reveals conservation of structure, function and post-transcriptional processes with mammalian receptors.

chick brain alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors


Input: Remarkably, both TTD-A and XP-D defects are associated with subunits of TFIIH, a basal transcription factor with a second function in DNA repair.

TFIIH


Input: Adjustment for age, total cholesterol, HDL cholesterol, triglycerides, current smoking, and systolic pressure slightly reduced the association between fibrinogen and atherosclerosis.

HDL cholesterol

fibrinogen


Input: Cholesterol side-chain cleavage cytochrome P450 (CYP11A; P450scc) gene expression is regulated by gonadotropins via cAMP in the ovary and by ACTH via cAMP in adrenal cortical cells.

Cholesterol side-chain cleavage cytochrome P450

gonadotropins

ACTH


Input: One possible solution is a thin radial forearm free flap.


Input: Structural analysis and characterization of tissue and hormonal responsive expression of the avian bone sialoprotein (BSP) gene.

avian bone sialoprotein

BSP


Input: The Y-type structural motif is also conserved among a number of divergent BiP mRNAs.

BiP mRNAs


Input: A false positive marker screen was associated with the occurrence of hand-foot syndrome even when the effect of regimen was accounted for by stratification (p =. 01).


Input: The detection of ORF-1 sequences in human tumors, while not proof per se, is a prerequisite for establishing its role in tumor development.


Input: Phylogenetic analysis gave evidence for a close evolutionary relationship between PhHV-1 and members of the Varicellovirus genus of the alpha-Herpesvirinae and canid herpesvirus in particular.


Input: In this method, PLP in plasma can be determined with high sensitivity using derivatization with sodium bisulfite in the mobile phase.


Input: Both HEF1 and Cas were found to complex with the related adhesion focal tyrosine kinase (RAFTK), and when tyrosine phosphorylated, with the adapter molecule CrkL.

Cas

related adhesion focal tyrosine kinase

RAFTK

CrkL


Input: SIM1 and SIM2 do not form homodimers, and they do not interact with AHR.

AHR


Input: Complexes of qTBP42 with each complementary strand of telomeric DNA and with quadruplex forms of the guanine-rich strand had 3. 7-14. 6 nM dissociation constants, Kd, whereas complexes with double-stranded telomeric DNA had up to 100-fold higher Kd values.


Input: Moreover, the effect exerted by TIS1 appeared to be selective for the MCK promoter.

MCK promoter


Input: What' s new in gynecologic and obstetrical surgery.


Input: The dnaK operon of Bacillus subtilis is heptacistronic.

dnaK operon of Bacillus subtilis


Input: Moreover, expression of CBF1 in yeast was found to activate transcription of reporter genes containing the C-repeat/DRE as an upstream activator sequence but not mutant versions of the DNA element.


Input: Forty-one ASA physical status I or II adult patients undergoing a variety of 1-1. 5 h surgical procedures were randomly allocated to receive CCA with desflurane or isoflurane with ventilation being either spontaneous or controlled.


Input: OBJECTIVE: Our goal was to determine whether chlamydia-infected women have a higher rate of febrile complications after postpartum tubal ligation.


Input: In the electrophoresis mobility shift assay using nuclear extracts of the myogenic cells, MyoD and myogenin bound to the right E-box in the enhancer region of the MCK gene even in the presence of BMP-2.

MyoD

myogenin

MCK gene


Input: A heterologous promoter construct containing three repeats of a consensus Sp1 site, cloned upstream of a single copy of the ZII (CREB/AP1) element from the BZLF1 promoter linked to the beta-globin TATA box, exhibited phorbol ester inducibility.

Sp1 site

ZII

BZLF1 promoter

beta-globin


Input: Subsequent experiments showed that motoric tasks rather than cognitive aspects of the COWA task were critical in potentiating finger-tapping performance.


Input: cDNA cloning, expression analysis, and chromosomal localization of a gene with high homology to wheat eIF-(iso) 4F and mammalian eIF-4G.

wheat eIF-(iso) 4F

mammalian eIF-4G


Input: Therefore, it is important to control hypertension and keep appropriate renal blood flow during living renal transplantation surgery.


Input: The initial patients treated with AZQ and mitroxantrone experienced prolonged bone marrow suppression and, therefore, subsequent cohorts were treated with G-CSF, 5 micrograms/kg, beginning the day after completion of the third cycle of chemotherapy.

G-CSF


Input: Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) activates a set of genes such as c-fos, jun, myc, and early growth response gene 1 (egr-1).

Human granulocyte-macrophage colony-stimulating factor

hGM-CSF

c-fos

jun

myc

early growth response gene 1


Input: In order to provide adequate local control without compromising cosmetic outcome, the amount of breast tissue that must be excised in BCT needs to be individualized.


Input: Surprisingly, however, TCR-mediated tyrosine phosphorylation of phospholipase C gamma 1 remains intact in the Jurkat cells expressing the A2/HCP chimera.

TCR

phospholipase C gamma 1

HCP


Input: The 14. 1 (IGLL1) gene is expressed in a lineage-and stage-restricted manner.

14. 1 (IGLL1) gene


Input: The interferon (IFN)-induced double-stranded RNA (dsRNA)-activated Ser/Thr protein kinase (PKR) plays a role in the antiviral and antiproliferative effects of IFN.

interferon

IFN

double-stranded RNA (dsRNA)-activated Ser/Thr protein kinase

PKR

IFN


Input: Together, the data suggest that cAMP-dependent control of the amounts of the activator SF-1 vs. the repressor COUP-TF could influence CRS2-dependent transcription.

COUP-TF


Input: Object relations, affect management, and psychic structure formation.


Input: When expressed in COS-7 cells, MKP-4 blocks activation of MAP kinases with the selectivity ERK > p38 = JNK/SAPK.

MAP kinases

ERK

JNK

SAPK


Input: Most kinases are not significantly inhibited by roscovitine. cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E and cdk5/p35 only are substantially inhibited (IC50 values of 0. 65, 0. 7, 0. 7 and 0. 2 microM, respectively). cdk4/cyclin D1 and cdk6/cyclin D2 are very poorly inhibited by roscovitine (IC50 > 100 microM).

cyclin B

cyclin A

cyclin E

cyclin D1

cyclin D2


Input: Interaction of Ets-1 and the POU-homeodomain protein GHF-1/Pit-1 reconstitutes pituitary-specific gene expression.

POU-homeodomain protein GHF-1


Input: Although Pho85 is not essential for viability, Pcl1, 2-Pho85 kinase complexes become essential for Start in the absence of Cln1, 2-Cdc28 kinases.

Pcl1, 2

Cln1, 2


Input: Using the yeast two-hybrid system to screen for proteins which interact with Tax1, we isolated the B subunit of the CCAAT binding protein NF-Y from a HeLa cDNA library.

NF-Y


Input: Enhancer activity requires both the AP-1 site and these adjacent sequences.

AP-1 site


Input: Studies using HLA-DR-B7-1-LFA-3 triple transfectants showed that the LFA-3-induced NF-AT DNA binding activity was negatively regulated by B7-1 costimulation.

HLA-DR

NF-AT


Input: Constitutive activation of Rac1 and RhoA causes tumorigenic transformation of NIH 3T3 cells, and their functions may be required for full Ras transformation.

RhoA

Ras


Input: Furthermore, Rac1 activation of JNK or SRF, or induction of lamellipodia, was neither necessary nor sufficient for Rac1 transforming activity.

JNK

SRF


Input: Overexpression of the bZip interaction domain of CBP specifically abolishes the positive cross talk between TR and p45/NF-E2.

CBP

TR


Input: This inhibitory domain has been deleted in all naturally occurring AHC deletion mutants described to date.

AHC deletion mutants


Input: Identification of a promoter-specific transactivation domain in the herpes simplex virus regulatory protein ICP4.

herpes simplex virus regulatory protein ICP4


Input: DNA sequencing of a 17-kb segment encompassing a gammaherpesvirus divergent locus (DL-B) between ORF11 and ORF17 revealed the presence of nine viral ORFs with predicted gene products related to cellular proteins.


Input: Studies in mammalian cells have correlated induction of inhibitory tyrosine 15 (Y15) phosphorylation on p34cdc2 with the response to DNA damage.


Input: We report herein the case of a 30-year-old man in whom ectopic mediastinal parathyroid adenoma was detected by 99mTc-methoxyisobutylisonitrile scintigraphy (99mTc-MIBI).


Input: Cardiac endothelin release and infarct size, myocardial blood flow, and ventricular function in canine infarction and reperfusion.

Cardiac endothelin