Input: CKII as a CD44-associated serine kinase therefore may serve as an important molecule in a signaling cascade that produces a variety of cellular responses in MDA231 breast cancer cells.

CKII

CD44-associated serine kinase


Input: Galphaq, Galpha12, and Galpha13, but not Galphai, activate SRF through RhoA.

Galphaq

Galphai

SRF

RhoA


Input: Additionally in seven subjects adrenaline (A) and noradrenaline (NA) concentrations were determined.


Input: Northern blot analyses show that the hBub1 mRNA level is abundantly expressed in tissues or cells with a high mitotic index.

hBub1 mRNA


Input: We mapped two overlapping expressed sequence tag clones within a genomic contig on human chromosome 5, band q31.


Input: Htra2-beta3 is developmentally regulated and expressed predominantly in brain, liver testis, and weakly in kidney.


Input: Gng3lg transcripts are expressed in a variety of tissues including both brain and testes.

Gng3lg transcripts


Input: Using an interspecific backcross panel, we localized both Gng3 and Gng3lg to the same locus on chromosome 19.


Input: We also raised a polyclonal antibody against the glutathione S-transferase fusion protein containing the NH2-terminal 86 amino acids of human NRAMP2.

glutathione S-transferase fusion protein

human NRAMP2


Input: Inhibition of the apolipoprotein B mRNA editing enzyme-complex by hnRNP C1 protein and 40S hnRNP complexes.

apolipoprotein B mRNA

hnRNP C1 protein

40S hnRNP complexes


Input: SRC-1 can relieve the NF-kappaB-mediated repression of GR activity.

NF-kappaB

GR


Input: However the sequence surrounding the transcription start site CTCA (+ 1) TTCC was similar to the consensus CTCA (+ 1) NTCT (N is any nucleoside) for an initiator element found in terminal deoxynucleotidyltransferase and a number of other highly regulated genes.

terminal deoxynucleotidyltransferase


Input: Expression of a dominant-negative mutant of JNK1 also suppressed glucose deprivation-induced JNK1 activation as well as HSP70 gene expression.

HSP70 gene


Input: The interaction of AF-1 with proteins that regulate distinct steps of transcription may provide a mechanism for synergistic activation of gene expression by AF-1.


Input: The role of protein kinase C signaling in activated DRA transcription.

protein kinase C

DRA


Input: Ligand binding to the receptor complex leads to tyrosine phosphorylation and activation of Janus kinases (Jak), phosphorylation of the signal transducing subunit gp130, followed by recruitment and phosphorylation of the signal transducer and activator of transcription factors STAT3 and STAT1 and the src homology domain (SH2)-containing protein tyrosine phosphatase (SHP2).

Janus kinases

Jak

signal transducing subunit gp130

signal transducer and activator of transcription factors STAT3

src homology domain

protein tyrosine phosphatase


Input: Interestingly, an increase of distance per se did not have a deleterious effect on translation efficiency.


Input: We also mapped a 3'-polyadenylation site 504bp downstream of the TGA stop codon, consistent with the 2. 5kb transcript size.


Input: RBP56 protein turned out to be hTAFII68 which was isolated as a TATA-binding protein associated factor (TAF) from a sub-population of TFIID complexes (Bertolotti A., Lutz, Y., Heard, D. J., Chambon, P., Tora, L., 1996. hTAFII68, a novel RNA/ssDNA-binding protein with homology to the proto-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II.

RBP56 protein

TATA-binding protein associated factor

TAF

TFIID complexes

TLS

FUS

EWS

TFIID

RNA polymerase II


Input: An electrophoretic mobility shift assay was performed to characterize the binding property of TR2 and its truncated isoform.


Input: Gel-mobility shift analysis was also performed for the CCAAT motif at-67.


Input: RESULTS: We identified a full-length cDNA with an open reading frame of 2883 bp corresponding to a predicted protein of 961 amino acids that shares greater than 95% homology with the rat gamma-aminobutyric acid B (GABAB) receptor.

rat gamma-aminobutyric acid B (GABAB) receptor


Input: On Day 8, the CIDR-B was removed and 500 micrograms cloprostenol injected, IM.


Input: Another tentative hotspot mutation in the third patient, a frame shift caused by a G nucleotide insertion in a monotonous repeat of six Gs in HPRT exon 3, has been reported previously in three other LN patients.

HPRT exon 3


Input: SRF-deficient embryos (Srf-/-) have a severe gastrulation defect and do not develop to term.

SRF

Srf


Input: These characteristic structural features were used to create the abbreviation AZF1 (Asparagine-rich Zinc Finger protein).

Asparagine-rich Zinc Finger protein


Input: Over-expression of Azf1p in the yeast cell does not influence the expression level of the mitochondrial transcription factor Mtf1p, indicating that the influence of Azf1p on the suppression of the special mitochondrial RNA polymerase mutant is an indirect one.

mitochondrial transcription factor Mtf1p

mitochondrial RNA polymerase mutant


Input: We have generated a computer model of the C-terminal domain of the 434 repressor based on the crystal structure of the homologous UmuD' protein.

homologous UmuD' protein


Input: Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.

EPO

CUTL1 loci


Input: Because Trp53 (the mouse homolog of human TP53) is located with Tk1 on chromosome 11 and is critical in regulating cellular responses following exposure to DNA damaging agents, we wanted to determine if these mouse lymphoma cells harbor mutations in Trp53.

mouse homolog of human TP53


Input: One of these fragments shows the highest amino acid sequence homology to the insect ecdysone inducible gene E75.

gene E75


Input: The full-length N gene, encoded by open reading frame 7, was cloned from the Canadian PRRS virus, PA-8.

N gene


Input: Based on sequence homology, the genes were identified as TEF, encoding translation elongation factor-1 alpha and RPS7, encoding ribosomal protein S7.

TEF

translation elongation factor-1 alpha


Input: We have previously shown that ARNO localizes to the plasma membrane in vivo and efficiently catalyzes ARF6 nucleotide exchange in vitro.

ARNO


Input: Renal pathology and long-term outcome in childhood SLE.


Input: Transcription factors of the Stat family are controlled by protein kinases.

Stat family


Input: We propose that two pathways regulate Stat5 serine phosphorylation, one that is prolactin-activated and PD98059-resistant and one that is constitutively active and PD98059-sensitive and preferentially targets Stat5a.

prolactin


Input: An approximately 37-kDa cytoplasmic protein is rapidly tyrosine-phosphorylated in the response of mouse BAC1. 2F5 macrophages to colony stimulating factor-1 (CSF-1). pp37 was purified from the cytosolic fraction by anti-Tyr (P) affinity chromatography, size exclusion chromatography, and C4 reverse phase high pressure liquid chromatography.

colony stimulating factor-1

anti-Tyr (P)


Input: Dose of 20 ig were administered within a scheme from 0. 1 to 6 months in order to study its immunogenicity, which was evaluated at 2, 7, and 12 months after the first dose.


Input: This association was independently significant for patients treated primarily (not for recurrence).


Input: CONCLUSION: Local control was highest with Preop in patients presenting primarily with gross disease, and with Postop in patients presenting primarily following gross total excision.


Input: Its interaction with RFX5 and RFXAP is essential for binding of the RFX complex to MHC-II promoters.

RFXAP

RFX complex

MHC-II promoters


Input: We have previously mapped the defect in RIIIS/J to distal mouse Chr 11, distinct from the Vwf locus on Chr 6.

Vwf locus


Input: These data may also aid in the localization of other disease loci mapped to this region, including the gene for tricho-dento-osseous syndrome and a murine locus for susceptibility to ozone-induced acute lung injury.


Input: Copyright 1998 Academic Press.


Input: An open reading frame encoding a protein which shows significant similarity to invertases and resolvases was located immediately upstream of the Pac25I R-M operon.

invertases

resolvases

Pac25I R-M operon


Input: Identification of a new gene in the streptococcal plasmid pLS1: the rnaI gene.

rnaI gene


Input: Rather, usp is required in late third instar larvae for appropriate developmental and transcriptional responses to the ecdysone pulse that triggers puparium formation.

usp


Input: An intact neurovascular supply is essential for the viability of a muscle flap.


Input: BACKGROUND: Studies in lean men show poor regulation of energy (EB) and fat balance (FB) during manipulation of dietary ratios of fat to carbohydrate.


Input: Fatal apneusis was observed under following conditions: (1) Persistent apnea was produced after a single KA microinjection in one side of the VRG-Apa (5 animals).


Input: A comparative analysis of the reported MOCT-associated malignant melanomas emphasizes the singularity of our case in the amelanotic character of the melanoma, its lymphotropism and the coexistence of invasive squamous cell carcinoma.


Input: These results indicate that HIV-1 Gag sequences can influence the viral PR-mediated processing of the MuLV TM Env protein p15 (E).

Gag sequences

viral PR

TM Env protein p15 (E)


Input: These results demonstrate a specific association of SIV and HIV-2 nef, but not HIV-1 nef, with TCRzeta.

HIV-2 nef

HIV-1 nef

TCRzeta


Input: Competition EMSA established that constitutively expressed nuclear proteins bound the KCS element selectively; KCS protein binding activity correlated with promoter activity in the transient transfection reporter assay.

KCS element

KCS protein


Input: Mechanism of interferon action: identification of essential positions within the novel 15-base-pair KCS element required for transcriptional activation of the RNA-dependent protein kinase pkr gene.

interferon

15-base-pair KCS element

RNA-dependent protein kinase pkr gene


Input: Expression of a novel murine phospholipase D homolog coincides with late neuronal development in the forebrain.

murine phospholipase D homolog


Input: We detected no effect of deleting YCL024W, either alone or in combination with deletion of GIN4.


Input: Paralemmin is also phosphorylated, and its mRNA is differentially spliced in a tissue-specific and developmentally regulated manner.

Paralemmin


Input: The deduced amino acid sequence of CBP90 had no significant similarity to any other protein, but it had a proline-rich domain at the C-terminal region.


Input: The effect of low-profile serine substitutions in the V3 loop of HIV-1 gp120 IIIB/LAI on the immunogenicity of the envelope protein.

gp120 IIIB

LAI

envelope


Input: Transcription start site mapping identified the presence of an aphidicolin-sensitive late transcript arising from a TAAG motif located at-352 nucleotides and an aphidicolin-insensitive early transcript originating from a TTGT motif located 35 nucleotides downstream to a TATA box at-312 nucleotides, with respect to the + 1 ATG of lef2.


Input: The human 2', 5'-oligoadenylate (2-5A) synthetases are members of a family interferon (IFN)-inducible anti-viral proteins.

human 2', 5'-oligoadenylate (2-5A) synthetases

interferon

IFN

anti-viral proteins


Input: Our findings demonstrate a dose-dependent blockade of the mechanical sensitivity caused by a mild thermal injury by both GBP and IBG.


Input: These striations were caused by contact between the sharp edge of the upper canine and the P3 during honing (canine/premolar complex).


Input: Low PbrO2 readings, however, could be caused by local microhemorrhages, undetectable on CT or MRI.


Input: The consequences of intensive swine production on the environment and possible solutions by means of nutrition are outlined.


Input: This study demonstrates that alteration of CDKN2 is one of the most frequent genetic abnormalities in prostate cancer and may contribute to prostate carcinogenesis.


Input: The pharmacokinetic parameters which helped predict these toxicities included area under the curve and peak plasma level.


Input: A Chinese (HK) SF-36 survey form was developed by an iterative translation process.


Input: However, the use of cyclosporin A is associated with an increased prevalence of hypertension in kidney transplant recipients.


Input: PURPOSE: To determine the effects of hypercholesterolemia and atherosclerosis-induced chronic cavernosal arterial insufficiency on cavernosal smooth muscle tone, nitric oxide synthase (NOS) activity and cavernosal tissue synthesis of constrictor eicosanoids.

nitric oxide synthase

NOS


Input: Characterization of the regulatory regions of the human aromatase (P450arom) gene involved in placenta-specific expression.

human aromatase


Input: Recombinant FVIIa was stable in the infusion pump for several days at room temperature and for 24 h at body temperature.

Recombinant FVIIa


Input: (1992) Biochemistry 31, 3351-3358].


Input: Levels of serum IgE were measured monthly, and nasal IgE was measured at the height and end of the season.

IgE

IgE


Input: A mutation in the 5' C2U4 repeat causes underaccumulation of snR13F, whereas mutations in the 3' C2U4 repeat cause the accumulation of two novel RNAs that migrate in the 500-nt range.


Input: By directly interacting with both Arfs and tyrosine kinases involved in regulating cell growth and cytoskeletal organization, ASAP1 could coordinate membrane remodeling events with these processes.

Arfs

tyrosine kinases


Input: These sorting nexins also associated with the long isoform of the leptin receptor but not with the short and medium isoforms.

sorting nexins

leptin receptor


Input: Cyclophilins are cis-trans-peptidyl-prolyl isomerases that bind to and are inhibited by the immunosuppressant cyclosporin A (CsA).

Cyclophilins

cis-trans-peptidyl-prolyl isomerases


Input: In vitro protein retention experiments in which Hsp90 heterocomplexes were precipitated resulted in coprecipitation of Cns1.

Hsp90 heterocomplexes


Input: The Ras-related GTPases are small, 20-to 25-kDa proteins which cycle between an inactive GDP-bound form and an active GTP-bound state.

Ras-related GTPases


Input: To modulate transcription, regulatory factors communicate with basal transcription factors and/or RNA polymerases in a variety of ways.

RNA polymerases


Input: Endogenous RMP was immunologically detected interacting with assembled RPB5 in RNA polymerase in mammalian cells.

RMP

RNA polymerase


Input: In this study, rabbits were used to evaluate the sutured wound reaction with Dexon or nylon in the conjunctival flap 1, 4, 7, 14 and 28 days after trabeculectomy surgery with or without the use of mitomycin-C.


Input: The mapping was completed with Southern blotting and restriction analysis.


Input: The zona pellucida (ZP), the extracellular glycocalyx that surrounds the oocyte, is well known to mediate homologous gamete interaction.


Input: Therapeutic use of continuous subcutaneous infusion of recombinant human erythropoietin in malnourished predialysis anemic patients with diabetic nephropathy.

recombinant human erythropoietin


Input: Although pathological thyroid function is related to changes in energy expenditure and body composition, its possible influence on leptin levels remains to be determined.

leptin


Input: These cognitive deficits were prevented in animals treated with MK-801 during SE.


Input: Here we demonstrate that the mechanism of activation of HIF-1alpha is a multi-step process which includes hypoxia-dependent nuclear import and activation (derepression) of the transactivation domain, resulting in recruitment of the CREB-binding protein (CBP)/p300 coactivator.

CREB-binding protein

CBP

p300 coactivator


Input: Thus, hypoxia-inducible nuclear import and transactivation by recruitment of CBP can be functionally separated from one another and play critical roles in signal transduction by HIF-1alpha.

CBP


Input: The rat aldolase C gene encodes a glycolytic enzyme strongly expressed in adult brain.

rat aldolase C gene


Input: A synergistic effect on HCK promoter activity was observed at high concentrations of Sp1.

HCK promoter


Input: Quinone-binding domain and amino acid residues involved in quinone binding.


Input: Western analyses with antisera raised against Lu-ECAM-1 peptides show that the N-terminal region of the predicted open reading frame is present only in the larger size proteins (i. e.

Lu-ECAM-1 peptides


Input: Mammalian sperm motility is regulated by a cascade of cAMP-dependent protein phosphorylation events mediated by protein kinase A.

protein kinase A


Input: In this paper, we show that, like BAP2, the expression of the BAP3 gene in S. cerevisiae is induced by the addition of branched-chain amino acids to the medium.

BAP3 gene


Input: Effect of enteral nutritional products differing in carbohydrate and fat on indices of carbohydrate and lipid metabolism in patients with NIDDM.


Input: Low-grade gastric MALT lymphoma and helicobacter heilmannii (Gastrospirillum hominis


Input: These studies support the view that HMG I (Y) is an important cofactor for HLA-DRA gene activation by Oct-2A and provide insights into its mechanism of action.

HMG I (Y)

HLA-DRA gene


Input: In contrast to hemodynamic and histopathological predictors of survival, vWF: Ag does not require invasive techniques to be determined.

vWF


Input: CONCLUSION: We were unable to identify features of disease likely to be associated with a clinically useful response to inhaled NO therapy using the parameters studied.


Input: We find that BCL-6 POZ domain mutations that disrupt the interaction with N-CoR and SMRT no longer repress transcription.

N-CoR

SMRT


Input: Partial characterization of the active site human platelet cAMP phosphodiesterase, PDE3A, by site-directed mutagenesis.

human platelet cAMP phosphodiesterase


Input: This core sequence, along with additional nonspecific downstream nucleotides, is sufficient for partial suppression of spliceosome assembly and splicing of BPV-1 pre-mRNAs.


Input: Over-expression of the cofactor p300, which functions as a coactivator of myoD-mediated transcription, alleviated repression by COUP-TF II.

myoD

COUP-TF II


Input: Familial autoimmune hepatitis and C4 deficiency


Input: Since glutathione peroxidase (GPX) and superoxide dismutase (SOD) play a significant role in erythrocyte antioxidative defence, it is very important to determine their activity in occupationally exposed workers.

glutathione peroxidase

GPX

superoxide dismutase

SOD


Input: Retroviral nucleocapsid proteins (NCPs) are CCHC-type zinc finger proteins that mediate virion RNA binding activities associated with retrovirus assembly and genomic RNA encapsidation.

Retroviral nucleocapsid proteins

NCPs

CCHC-type zinc finger proteins


Input: The Schizosaccharomyces pombe rad1 + cell cycle checkpoint control gene is required for S-phase and G2/M arrest in response to both DNA damage and incomplete DNA replication.

Schizosaccharomyces pombe rad1 + cell cycle checkpoint control gene


Input: It is now well established that progression through the eukaryotic cell cycle is controlled by oscillations in the activity of cyclin-dependent kinases (CDKs).

cyclin-dependent kinases

CDKs


Input: Positive genetic selections for inhibition of cyclin/CDK function were characterized using the E. coli neo and yeast LEU2 genes.

cyclin

CDK

E. coli neo

yeast LEU2 genes


Input: The hematopoietic colony-stimulating factors (CSF) have been introduced into clinical practice as additional supportive measures that can reduce the incidence of infectious complications in patients with cancer and neutropenia.

hematopoietic colony-stimulating factors

CSF


Input: All injections of CSF were given after the initiation of neutropenia and continued until the occurrence of an absolute neutrophil recovery. rHu GM-CSF and rHu G-CSF, administered once daily at the 250 microg m (-2) day (-1) and 5 microg kg (-1) day (-1) level, were effective in increasing the absolute neutrophil count and neutrophil function, as measured by an automated chemiluminescence system.

CSF

rHu GM-CSF

rHu G-CSF


Input: We evaluated regional right ventricular wall motion during systole in patients with surgically repaired tetralogy of Fallot (TOF) using color kinesis imaging.


Input: Interestingly, we find that the interaction between Tat and hCycT1 requires zinc as well as essential cysteine residues in both proteins.

Tat


Input: During early neurogenesis, Vnd protein is restricted to ventral column neuroectoderm and neuroblasts; later it is detected in a complex pattern of neurons.

Vnd protein


Input: The repression domain, and indeed the entire Cdc68 protein, is highly conserved, as shown by the sequence of the Cdc68 functional homolog from the yeast Kluyveromyces lactis and by database searches.

Cdc68 protein

Cdc68 functional homolog


Input: The exodomain alone has the high affinity hormone binding site but is not capable of generating hormonal signal.


Input: Pyrrolidine dithiocarbamate, a potent transcriptional inhibitor of the viral LTR, abrogated the cytokine responses in both U1 and ACH-2 cells, suggesting a common TNF-alpha-mediated transcriptional mechanism in these cell types despite their different modes of provirus latency.

viral LTR

TNF-alpha


Input: Furthermore, synergistic activation of ERK2 occurred in the absence of changes in intracellular Ca2 +, and was not blocked by inhibition of protein kinase C activity and represents a separate pathway by which CD19 regulates B cell function.

protein kinase C


Input: The retrovesical hydatid cyst is a very rare site.


Input: Biochemical analysis reveals that KS1 is a nuclear protein containing two transcriptional repressor domains, R1 and R2.


Input: However, the BCH group showed inferior gross motor performance on the Bruininks-Oseretsky Test of Motor Proficiency (Bruininks 1978).


Input: We report here that, for a constant amount of transfected DNA, the level of chloramphenicol acetyltransferase (CAT) mRNA is increased in Vpr-expressing cells using either HIV-1 or a murine leukemia virus (MLV) SL3-3 LTR-CAT reporter construct.

chloramphenicol acetyltransferase

CAT

Vpr

leukemia virus (MLV) SL3-3 LTR

CAT


Input: We identified telSMN mutations in 11 of these unrelated SMA-like individuals who carry a single copy of telSMN: these include two frameshift mutations (800ins11 and 542delGT) and three missense mutations (A2G, S262I, and T274I).

telSMN

telSMN


Input: The decrease of TNF receptors by IL-4 was accompanied by down-regulation of TNF-induced activities, including cytotoxicity, caspase-3 activation, NF-kappaB and AP-1 activation, and c-Jun N-terminal kinase induction.

TNF receptors

TNF

NF-kappaB

c-Jun N-terminal kinase


Input: Type 2 deiodinase (D2) catalyzes the 5'-deiodination of thyroxine to form 3, 5, 3'-triiodothyronine.

Type 2 deiodinase


Input: We have identified two overlapping expressed sequence tag clones, which contain the missing 4. 4-kb 3'-UTR of the human D2 (hD2) cDNA.

human D2


Input: Biol.


Input: Here we have investigated the structural requirements and consequences of regulatory phosphorylation for the interaction between c-Jun and JNK in vivo.

c-Jun

JNK


Input: Immunolocalization of Sop1p revealed a cytoplasmic distribution and cell fractionation studies showed that a significant fraction of Sop1p was recovered in a sedimentable fraction of the cytosolic material.


Input: Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK).

c-Jun N-terminal kinase

stress-activated protein kinase

JNK

SAPK


Input: Here we report the full-length coding cDNA sequence of the mouse homologue of MPP3.

mouse homologue of MPP3


Input: The method also eliminates tagging of venous spins and concern about asymmetric magnetization transfer effects.


Input: Consistent with this, purified Dlk phosphorylated core histones H3, H2A and H4 as exogenous substrates and endogenous histone H3 in kinase assays with nuclear extracts.

Dlk

histones H3

histone H3


Input: Neither Ha-Ras (G12V, T35S) (Ha-RasV12S35), which activates the Rafl signaling pathway, nor Ha-Ras (G12V, E37G) (Ha-RasV12G37), which stimulates the RalGDS pathway, did not have significant effects on factor-withdrawal apoptosis of myeloid cells.

Ha-Ras

Rafl

Ha-Ras (G12V, E37G)

RalGDS


Input: We have isolated a novel human cyclin, cyclin E2, that contains significant homology to cyclin E.

human cyclin

cyclin E2

cyclin E


Input: Initial experience with the new technology indicates that SieScape is an alternative to other methods such as CT and MRI.


Input: The dopamine D4 receptor as well as many other catecholaminergic receptors contain several putative SH3 binding domains.

dopamine D4 receptor

catecholaminergic receptors

SH3 binding domains


Input: Schizosaccharomyces pombe cells respond to nutrient deprivation by altering G2/M cell size control.


Input: A-tracts functioned best when positioned close to the-35 hexamer rather than one helical turn farther upstream, similar to the positioning optimal for UP element function.


Input: Pyk2 phosphorylation increased upon adherence of FLG 29. 1 cells to fibronectin and to ST2 stromal cells.

fibronectin


Input: Raf is a key serine-threonine protein kinase which participates in the transmission of growth, anti-apoptotic and differentiation messages.

Raf

serine-threonine protein kinase


Input: The US National Institute on Alcohol Abuse and Alcoholism (NIAAA) recognizes two forms of problematic drinking:' willful alcohol abuse', a behavioural problem, and' alcohol dependence', a true medical disorder, which includes a genetic component, that can be scientifically understood and medically treated.


Input: Collagen was extracted from the skin, and the lack of type III collagen was determined by means of sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE).

Collagen

type III collagen


Input: RESULTS: During the 7-year period, 10, 331 symptomatic duodenal ulcer diseases were diagnosed.


Input: In turn, assembly of this complex mediates the enzymatic activation of the p21-activated protein kinase 1 and facilitates actin polymerization.

p21-activated protein kinase 1

actin


Input: Jembrana disease virus (JDV) is a newly identified bovine lentivirus that is closely related to the bovine immunodeficiency virus (BIV).


Input: Approximately 50% of the residues are conserved among all three sequences, yet all three viruses have retained response elements for glucocorticoids, two positionally conserved CCAAT boxes, and positionally conserved TATA boxes.


Input: Nhp2p is a highly basic protein that belongs to a family of putative RNA-binding proteins.


Input: This survey included 3000 randomly selected Norwegians above 18 years of age who received the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30 (+ 3) by mail.


Input: During presentation of happy facial expressions, we detected a signal increase predominantly in the left anterior cingulate gyrus, bilateral posterior cingulate gyri, medial frontal cortex and right supramarginal gyrus, brain regions previously implicated in visuospatial and emotion processing tasks.


Input: Down-regulation of IRS-1 is linked to its serine phosphorylation dependent on PI 3-kinase activity and appears required for differentiation to occur, as IRS-1 is not modified and continues to accumulate in a nondifferentiating myoblast cell line.

PI 3-kinase


Input: This study utilizes the mammalian two-hybrid system to examine the role of ligand in the dimerization of human progesterone receptor (hPR).

human progesterone receptor

hPR


Input: One of its unique features appears to be the unusually short 5'-untranslated regions (UTR) (1-6 nucleotides (nts)) and the apparent absence of 5'-cap structures from its mRNAs.


Input: The gene encoding human tissue-type plasminogen activator (t-PA) is regulated in a cell-type-specific manner.

gene encoding human tissue-type plasminogen activator

t-PA


Input: Both the presence of arginine and anaerobiosis are needed to trigger induction of the pathway.


Input: Competition with a putative MADS box consensus binding site from the promoter of the coordinately regulated opaque-phase-specific gene PEP1 (SAP1) and the human MADS box consensus binding site for serum response factor demonstrated that one of the three complexes formed was specific to the OP4 sequence.

MADS box

opaque-phase-specific gene PEP1

human MADS box consensus binding site

serum response factor

OP4 sequence


Input: The human SHBG proximal promoter was analyzed by DNase I footprinting, and the functional significance of 6 footprinted regions (FP1-FP6) within the proximal promoter was studied in human HepG2 hepatoblastoma cells.

human SHBG proximal promoter

DNase I


Input: In vitro translation and in vivo polysome profile analysis indicated that transcripts C and E were translated with similar translational efficiencies that are substantially greater than that of transcript D, suggesting that 5'-untranslated regions play a role in translational control.

transcripts C and E

transcript D


Input: We have introduced a mutation (Ser36--> Asn) into this domain of p190 that decreased its ability to bind guanine nucleotide when expressed as a hemagglutinin (HA)-tagged protein in COS cells.

hemagglutinin

HA


Input: Wild type HA-p190 induced a phenotype of rounded cells with long, beaded extensions similar to that seen when Rho function is disrupted by ADP-ribosylation.

HA

Rho


Input: We emphasize that ANCA-associated vasculitis is another important complication of RA.

ANCA


Input: The downstream, TATA-less promoter has high G + C content, and exon 1b predominates among abundantly expressed mRNA species.


Input: Although we predicted that overexpression of the COOH-terminal domains, which were thought to be involved in the regulation of SREBP processing, would result in disruption of the SREBP-dependent transcriptional regulation of several genes, the mRNA levels for 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) synthase in these two cell lines were regulated in a sterol-dependent manner.

SREBP

SREBP

3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) synthase


Input: Dry matter intake, apparent nutrient digestibilities, serum chemistry profiles, sphingolipid concentrations, and persistency of FB1 in tissues were evaluated.


Input: However, no studies have been conducted to further investigate this potentially hazardous effect of lidocaine.


Input: E., Scott, J.


Input: Yap1p is constitutively nuclear in a crm1 mutant, and Crm1p binds to a nuclear export sequence (NES)-like sequence in Yap1p in the presence of RanGTP.

crm1 mutant

RanGTP


Input: Mean intake of vitamin A amounted to 1. 1 and 0. 9 mg RE/day for men and women, respectively; the contributions of meat, fats and oils, vegetables and dairy products to total intake were 35%, 24%, 16%, and 16%, respectively.


Input: Furthermore, RING1 overexpression results in enhanced expression of the proto-oncogenes c-jun and c-fos.

c-jun

c-fos


Input: The yeast RER2 gene, identified by endoplasmic reticulum protein localization mutations, encodes cis-prenyltransferase, a key enzyme in dolichol synthesis.

yeast RER2 gene

cis-prenyltransferase


Input: The yeast retrotransposon Ty5 preferentially integrates into regions of silent chromatin.

retrotransposon Ty5


Input: The loss of SKO1 completely restored ENA1 expression in a hog1 mutant and partially suppressed the osmotic stress sensitivity, qualifying Sko1p as a downstream effector of the HOG pathway.

hog1 mutant

HOG


Input: Elevated expression of a previously uncharacterized gene, SPP381, efficiently suppresses the growth and splicing defects of a temperature-sensitive (Ts) mutant prp38-1.

mutant prp38-1


Input: The slower-electrophoretic-mobility form of p68 was absent in human cells in G1/S and appeared as the cells entered G2/M.


Input: We have identified amino acid sequences in mammalian and Xenopus NeuroD1/BETA2 that are necessary for insulin gene expression and ectopic neurogenesis.

insulin gene


Input: Recent studies have suggested that Y319 also positively regulate ZAP-70 function.


Input: Genetic and molecular data indicate that wild-type Pan and CiD compete for binding to Arm, leading to a compromised transduction of the Wg signal in heterozygous ciD/+ animals and to a dramatic enhancement of the gain-of-function activity of CiD in homozygous mutants.

wild-type Pan

CiD

Arm

Wg

ciD/+

CiD


Input: Another ORF, dda. 2 located between modA and dda, shares sequence similarity with sigma70, and we call it srd.

dda. 2

modA

dda

srd


Input: The location of the IBS within the catB structural gene, the cooperativity observed in footprinting studies and phasing studies suggest that the IBS participates in the interaction of CatR with the upstream binding sites by looping out the intervening DNA.

catB structural gene

CatR


Input: In vitro transcription assays demonstrate that the TCA-cycle intermediate, fumarate, directly and specifically inhibits the formation of the clcA transcript.

clcA transcript


Input: BIAcore analysis gave a Kaff of 4. 4 x 10 (10) M-1 for the binding of N-A3 to T84. 1 and 2. 2 x 10 (10) M-1 for the binding of N-A3 to T84. 66.

T84. 1

T84. 66


Input: Expression of p130 (Cas) (Cas), a major binding protein for the Crk SH2-domain, also induced JNK activation, which was blocked by the SH2-mutant of Crk.

Cas

Cas

Crk SH2-domain

JNK

Crk


Input: Positive correlations were seen between the measurements for protein intake (r =. 58, P =. 0026) energy intake (r =. 78, P <. 00001), with mean differences of. 066 g/kg/d (SD. 38) 2. 04 kcal/kg/day (SD 6. 67), respectively.


Input: The Og4C3 enzyme-linked immunosorbent assay (ELISA) to detect circulating Wuchereria bancrofti antigen uses 50 microL of serum.

Wuchereria bancrofti antigen


Input: We now show that gp200-MR6 ligation can also mimic IL-4 and have an anti-proliferative pro-maturational influence within the immune system, causing up-regulation of co-stimulatory molecules on B lymphocytes.


Input: The Mig1 repressor is a zinc finger protein that mediates glucose repression in yeast.

Mig1 repressor

zinc finger protein


Input: Recurrent arterial thrombotic disease on young onset and protein S deficiency.

protein S


Input: We showed that Stat3 and Stat3beta were affinity purified using phosphopeptides containing Y704 and Y744 but not by nonphosphorylated peptide analogues or by phosphopeptides containing Y729 and Y764.


Input: Taken together, our results indicate that the FCR1 gene behaves as a negative regulator of drug resistance in C. albicans and constitute the first evidence that FCZ resistance can result from the inactivation of a regulatory factor such as Fcr1p.

FCR1 gene


Input: These findings suggest that late MYO/M is more useful than washout rate to assess the effect of treatment on heart failure due to DCM.


Input: This study was undertaken to evaluate how couplers and their placement affect the ALGO2 click spectral properties.


Input: CONCLUSIONS: Pretreatment with OCs prior to pituitary suppression in the early follicular phase decreases ovarian cyst formation, without an apparent effect on subsequent follicular recruitment or pregnancy rates.


Input: With regard to the optimal threshold values, sensitivity and specificity were 100%/97% and 95%/95% with FDG PET, compared to 86%/92% and 77%/82% with IS, respectively.


Input: Dorsal root ganglia neuron-specific promoter activity of the rabbit beta-galactoside alpha1, 2-fucosyltransferase gene.

rabbit beta-galactoside alpha1, 2-fucosyltransferase gene


Input: This suggests roles for both the CE1 and CE2 elements in regulating Hoxb1 gene expression during development.

Hoxb1 gene


Input: CAL gain amounted to 4. 2 +/-1. 3 mm, 60% of the defects showing CAL gain > or = 4 mm.


Input: Lead fixation in dogs achieved with RF energy.


Input: Further, we show that this EIA-inducible CBF/cdc2 is related to the CBF which was shown to activate the heat shock protein 70 promoter.

EIA

CBF

heat shock protein 70 promoter


Input: The percutaneous absorption of clindamycin was studied in healthy male volunteers, comparing two investigative clindamycin (% w/v)/tretinoin (0. 025% w/v) gels, containing clindamycin phosphate ester and clindamycin HCl, respectively, relative to a clindamycin phosphate lotion (1% clindamycin; Dalacin T).


Input: The BAL concentrations of the nine cytokines evaluated for the more and less affected lungs were compared: interleukin-6 (IL-6), IL-8, IL-12, tumor necrosis factor-alpha (TNF-alpha), and interferon gamma (IFN-gamma) showed significant differences (p ranged between 0.

tumor necrosis factor-alpha

TNF-alpha

interferon gamma

IFN-gamma


Input: Phosphorylation analyses indicated that inhibition of ERK-1/2 decreased okadaic acid-elevated phosphorylation of JunD and FosB.

JunD

FosB


Input: Two-way analysis of variance was used to determine whether composite knowledge score differed among patient groups.


Input: The human pathogenic bacterium group A Streptococcus produces an extracellular cysteine protease [streptococcal pyrogenic exotoxin B (SpeB)] that is a critical virulence factor for invasive disease episodes.

cysteine protease

streptococcal pyrogenic exotoxin B

SpeB


Input: The orbitofrontal, cingulate, and anteromedial part of the dorsal premotor areas were preferentially activated by the self-initiated hand movement task (SELF).


Input: The peroxisome biogenesis disorders (PBDs) are a set of lethal genetic diseases characterized by peroxisomal metabolic deficiencies, multisystem abnormalities, mental retardation, and premature death.


Input: The active site includes the acidic triad Asp53 (the site of phosphorylation), Asp10 and Glu9.


Input: In PAV-3, the E1A region is located between 1. 5 and 3. 8 map units.

E1A region


Input: Six putative MDV genome products, including one Rep and five non-Rep proteins, show high (70. 4-90. 9%) amino acid identity to the corresponding six FBNYV proteins, whereas two other Rep proteins encoded by MDV-C2 and C3 are 82. 3% and 73. 0% identical to those encoded by SCSV-C2 and C6, respectively.

Rep

Rep

FBNYV proteins

Rep proteins


Input: MPO was labeled with 1 mCi 125I by a technique of self-labeling in the presence of 10 (-4) M hydrogen peroxide.

MPO


Input: It is related to a variety of mammalian Golgi-associated proteins and to the yeast Uso1p, an essential protein involved in docking of endoplasmic reticulum-derived vesicles to the cis-Golgi.


Input: The data indicate that Bmp2 is directly regulated by retinoic acid-bound receptors and Sp1.


Input: Both proteins were shown to be constitutively associated with tubulin.

tubulin


Input: HEED was found to bind to MA protein in vitro, as efficiently as in vivo in yeast cells.

HEED

MA protein


Input: Fas-resistant DT-40 lymphoma B-cells rendered BTK-deficient through targeted disruption of the btk gene by homologous recombination knockout underwent apoptosis after Fas ligation, but wild-type DT-40 cells or BTK-deficient DT-40 cells reconstituted with wild-type human btk gene did not.

Fas

BTK

btk gene

Fas

BTK

wild-type human btk gene


Input: Varicella-zoster virus (VZV) glycoprotein gI is a type 1 transmembrane glycoprotein which is one component of the heterodimeric gE: gI Fc receptor complex.

Varicella-zoster virus (VZV) glycoprotein gI

type 1 transmembrane glycoprotein

gE

gI Fc receptor


Input: To this end, we analyzed the phosphorylation status of a universal tyrosine kinase substrate, the transforming Shc adapter protein, in fibroblasts expressing the viral oncogene.

tyrosine kinase

Shc adapter protein


Input: These genes were expressed in a Saccharomyces cerevisiae mutant in which the endogenous ferrochelatase gene (HEM15) had been deleted, and the phenotypes of the transformants were characterized.

endogenous ferrochelatase gene


Input: In this study, evidence is presented that temporally and spatially specific mef2 expression is controlled by a complex array of cis-acting regulatory modules that are responsive to different genetic signals.


Input: Furthermore, using transgenic mouse technology we localized independent cis-regulatory elements controlling the tissue-specific expression of Pax6.


Input: In the second experiment, a stable nickel isotope, 61Ni, was given in drinking water to 20 nickel-sensitized women and 20 age-matched controls, both groups having vesicular hand eczema of the pompholyx type.


Input: Folded tissue and crimped collagen fibers in the tunica albuginea permit its expansion during erection.

collagen


Input: Number of patients infected with nontuberculous mycobacteria (NTM) is increasing world-wide in recent years.


Input: Comparison of the sequences of attP, attB and bacteria-prophage junctions attL and attR showed a 26 bp common core sequence, where recombination takes place, near the 5' end of the integrase gene.

attP

attB

attL

attR

integrase gene


Input: Interferon-alpha treatment of posttransplant lymphoproliferative disorder in recipients of solid organ transplants.

Interferon-alpha


Input: Immunological testing was performed on all brewery workers and some control volunteers using skin prick testing with hops, barley, and yeast antigens as well as other nonoccupational allergens, and by determining total serum IgE levels.

serum IgE


Input: OBJECTIVE: To evaluate the accuracy of working casts for crown and bridge restorations made from twin mix putty/wash silicone elastomeric impression materials using different types of stock tray.


Input: OBJECTIVES: To assess the ability of pretreatment and post-treatment prostate-specific antigen (PSA) measurements, clinical tumor stage, tumor grade, Gleason sum, race, age, and radiation dose to predict the recurrence of prostate cancer following external beam radiation therapy (XRT) since the introduction of PSA as a tumor marker at one tertiary care center.

prostate-specific antigen

PSA

PSA


Input: To evaluate whether the human gene is also a target of thyroid hormone we have searched for T3-responsive elements in NRGN cloned genomic fragments spanning the whole gene.

NRGN


Input: The transcriptional activity of PPARgamma is positively modulated by ligand binding and negatively regulated by phosphorylation mediated by the MEK/ERK signaling pathway.

PPARgamma

MEK

ERK


Input: BACKGROUND: Diazepam, one of the benzodiazepine group of tranquilizers, is used as an adjunctive drug for sedation and for relief of anxiety in the treatment of epilepsy.


Input: Bioplastique granuloma presents with irregularly shaped cystic spaces of varying size containing jagged, translucent, nonbirefringent foreign bodies whereas Artecoll granuloma shows numerous round vacuoles nearly identical in size and shape enclosing round and sharply circumscribed, translucent, nonbirefringent foreign bodies.


Input: This Tbx6-subfamily gene is likely to participate in paraxial mesoderm formation and somitogenesis in human embryo.

Tbx6-subfamily gene


Input: Structure-function analysis of the Z-DNA-binding domain Zalpha of dsRNA adenosine deaminase type I reveals similarity to the (alpha + beta) family of helix-turn-helix proteins.

dsRNA adenosine deaminase type I

(alpha + beta) family

helix-turn-helix proteins


Input: In addition, the regulation of Glvr-1 gene expression also has potential applications to gene therapy, since retroviral vectors carrying gibbon ape leukemia virus envelope proteins are used for gene delivery into different cell types.

Glvr-1 gene

gibbon ape leukemia virus envelope proteins


Input: Carbohydrates and glycoconjugates biophysical methods.


Input: Molecular cloning of mouse glycolate oxidase.

mouse glycolate oxidase


Input: In such a manner, activated PKR inhibits cell growth and induces apoptosis, whereas disruption of normal PKR signaling results in unregulated cell growth.

PKR

PKR


Input: We isolated a ribosomal protein L18 by interaction with PKR.

ribosomal protein L18

PKR


Input: Processing of the polycistronic precursor requires nucleases also involved in rRNA processing, i. e., Rnt1p and Rat1p.


Input: Furthermore, rhoA-mediated SRE activation was blocked by dominant negative mutants of PKC-alpha or PKC-epsilon.

rhoA

PKC-alpha

PKC-epsilon


Input: Nip7p-depleted cells exhibited the same defects as Nop8p-depleted cells, except that they accumulated 27S precursors.

27S precursors


Input: We show that the Sm-binding site and stem-loop III structures are necessary for correct 3'-end formation.

Sm-binding site


Input: Five different subtypes of spondyloarthropathy (SpA) are now recognized.


Input: Further experiments will be required to highlight the in vivo role of ELE1 in nuclear receptor functioning.


Input: Overexpression of PTTG in transfected NIH 3T3 cells also stimulated expression and secretion of basic fibroblast growth factor, a human pituitary tumor growth-regulating factor.

PTTG

basic fibroblast growth factor

human pituitary tumor growth-regulating factor


Input: The perifascicular connective tissue sheath is important in organising the contraction of the myocardium by preventing lateral spread of conduction and by permitting transmission of the impulse only at the termination of the purkinje fibre.


Input: E1, a DNA helicase, collaborates with the HPV E2 protein in ori-dependent replication.

DNA helicase

HPV E2 protein


Input: Here we describe a mutant alpha subunit designed to inhibit receptor-mediated hormonal activation of Gs, the stimulatory regulator of adenylyl cyclase.

Gs

adenylyl cyclase


Input: A gapped search with the C-terminal region of CDED/LIOR revealed a 36-41% similarity to several proteins related to signal transduction and cell replication, such as ORC1 and KSR.

CDED

LIOR

KSR


Input: Northern blot analysis demonstrated the ubiquitous expression of 2. 9 kb and 3.


Input: Additionally, a variety of regulatory schemes contribute temporal and/or spatial restriction to TGF-beta responses.

TGF-beta


Input: A comparison of the clinical profile of cavernous malformations with and without associated venous malformations.


Input: Magnetically induced optical self-pulsing in a nonlinear resonator.


Input: Wave cybernetics: A simple model of wave-controlled nonlinear and nonlocal cooperative phenomena.


Input: Autoionization rates and energy levels of triplet nf, v = 1 Rydberg states of H2.


Input: Unitary-group approach to spin-dependent operators.


Input: Nonlocal approach to scattering in a one-dimensional problem.


Input: Soft-x-ray lasing at 32. 6 nm in Ne-like Ti ions driven by 40 J of energy from two 650-ps laser pulses.


Input: Next, to identify regions of the promoter involved, we examined a series of tenascin-C promoter constructs with 5' deletions and showed that denatured collagen-dependent promoter activity was retained by a 122-base pair element, located-43 to-165 bp upstream of the RNA start site.

tenascin-C promoter constructs

collagen-dependent promoter


Input: Nuclear factor kappa B (NF-kappaB) is an important transcription factor for the genes of many pro-inflammatory proteins and is strongly activated by the cytokines interleukin-1 and tumor necrosis factor (TNF) alpha under various pathological conditions.

Nuclear factor kappa B

NF-kappaB

tumor necrosis factor (TNF) alpha


Input: Unilateral naris occlusion and the rat accessory olfactory bulb.


Input: The promoter of the rat pgp2/mdr1b gene has a GC-rich region (pgp2GC) that is highly conserved in mdr genes and contains an consensus Sp1 site.

mdr genes

Sp1 site


Input: Sp1' s role in transactivation of the pgp2/mdr1b promoter was tested in Drosophila Schneider cells.


Input: Measurements included bone mineral density of the lumbar spine and proximal femur (by dual-energy X-ray absorptiometry) and biochemical markers of bone remodeling (serum bone-specific alkaline phosphatase by immunoassay and urine deoxypyridinoline by high-pressure liquid chromatography).

alkaline phosphatase


Input: Human MGP is a 10-kD skeletal extracellular matrix (ECM) protein that consists of an 84-aa mature protein and a 19-aa transmembrane signal peptide.

Human MGP

10-kD skeletal extracellular matrix (ECM) protein


Input: Dual roles of p82, the clam CPEB homolog, in cytoplasmic polyadenylation and translational masking.

CPEB homolog


Input: The pattern of RNase E digestion of finP305 RNA differed from FinP, and GST-FinO did not protect finP305 RNA from cleavage in vitro.

RNase E

finP305 RNA

FinP

GST

FinO

finP305 RNA


Input: Transcription readthrough into the inverted repeats has little effect on this event.


Input: In the second case, an epidermal cyst was diagnosed.


Input: MotA also binds a DNA sequence (a MotA box), centered at position-30.

MotA

MotA box


Input: We suggest that MotA and AsiA may function like certain eukaryotic TAFs (TATA binding protein (TBP) associated factors) whose binding to TBP results in transcription from new core promoter sequences.

MotA

AsiA

eukaryotic TAFs

TATA binding protein (TBP) associated factors

TBP


Input: The S229A variant can better flip modified bases but does not tightly lock the flipped base into the adenine-binding pocket, suggesting that Ser229 could form a contact to the flipped adenine.


Input: The high conservation of the 3' terminus suggests that this region directs the assembly of proteins required for the initiation of RNA replication.


Input: All stimulations were down-regulated with GnRH-a commenced on day 21 in a long protocol before gonadotropin stimulation.

GnRH-a

gonadotropin


Input: The sequence up to-267 bp relative to the transcription start site was sufficient to enhance reporter gene expression depending on the mesodermal differentiation of P19 cells.


Input: No significant differences between the substituted and wild type peptides were observed, suggesting that this substitution in the intact protein may cause disruption of global rather than local structures.


Input: C3 toxin completely inhibited RhoA function, partially inhibited SRE: Luc activity, but had no effect on LPA-stimulated c-Fos expression.

C3 toxin

RhoA

Luc

c-Fos


Input: However, C3 toxin alone or in combination with growth factors did not stimulate AP-1: Luc activity and actually antagonized the synergistic activation of AP-1: Luc observed in response to co-stimulation with growth factors and Ro-31-8220.

C3 toxin

Luc

Luc


Input: The aim of the present study was to examine the antimicrobial susceptibility to 10 currently used antimicrobial agents of 50 strains of P. acnes isolated from acne lesions and identified using a Rap ID ANA II panel.


Input: The role of intraoperative echocardiography in surgery of the heart and large vessels


Input: Taken together, our results demonstrate that CAP1 is involved in multidrug resistance and oxidative stress response in C. albicans.


Input: Trinipatch is a small, transparent, matricial, monolayer patch with an absorption promoter, marketed in two dose-strengths (5 mg/24 h and 10 mg/24 h) by Laboratoires Synthelabo.


Input: The RMRI was tested for interrater reliability using three simulated and 10 actual patients.


Input: The starting point is the consideration that the conceptions underlying the ICIDH are not suitable to serve as a mainstay of a model for diagnostics in rehabilitation because they do not reflect essential characteristics of the diagnostic process which is the basis for intervention.


Input: OBJECTIVE: This meta-analysis of 67 controlled trials was performed to quantify the cholesterol-lowering effect of major dietary fibers.


Input: When the high affinity hnRNP A1 binding site was inserted into the beta-globin reporter, Rev was able to increase the cytoplasmic levels of unspliced mRNAs to 14%.

hnRNP A1 binding site

beta-globin reporter

Rev


Input: To date, two such proteins, PLZF and LAZ-3/BCL-6, have been implicated in oncogenesis.

PLZF


Input: Overexpression of POG1 inhibits alpha-factor-induced G1 arrest and transcriptional repression of the CLN1 and CLN2 genes.

alpha-factor

CLN2 genes


Input: We now show that RNU2 fragility can be induced by transfection with an expression vector encoding Ad12 E1B 55 kDa alone but not by an E1 vector encoding all E1 products (3 E1A proteins, as well as the E1B 19 kDa and 55 kDa proteins).

Ad12 E1B

E1 products

E1A proteins


Input: Competitionsupershift EMSA assays revealed that multiple proteins were involved in bandshift complex formation with KCS, one of which was identified as factor Sp1.

KCS


Input: Similarity of DNA binding and transcriptional regulation by Caenorhabditis elegans MAB-3 and Drosophila melanogaster DSX suggests conservation of sex determining mechanisms.

Caenorhabditis elegans MAB-3

Drosophila melanogaster DSX


Input: Neither the p42/44 nor the JNK pathway was involved in the action of IL-1beta.

JNK


Input: In protocol 2, eight different subjects performed Con and Ecc arm curls to fatigue, followed by postexercise muscle ischemia, by using the same resistance as in protocol 1.


Input: Airflow was measured with a custom-designed turbine and a 45-ft.-long cable to reach the volume-measuring module.


Input: Both mutations confer amino acid substitutions in the viral coat protein but differ in their relative abilities to utilize the foreign scaffolding protein.

viral coat protein

scaffolding protein


Input: Complete recovery of liver function after this surgery tended to be slow.


Input: Although both transcripts share the first nine exons, exon 10 of ZIS-2 is lacking in ZIS-1, and instead, exon 11 (10th exon) of ZIS-1 is larger in size, leading to the longer 3'-UTR.


Input: IFN-gamma was elevated during active TB when compared with healthy controls, declining during and after treatment.

IFN-gamma


Input: The missing 5' sequences were obtained by 5'-rapid amplification of cDNA ends and by analysis of an NHE5 genomic clone, and the missing 3' sequences were obtained by 3'-rapid amplification of cDNA ends.

NHE5 genomic clone


Input: If no alloantibodies are detected, further analysis to define a role of drug-related or autoantibodies is required.


Input: This dependence, however, can be overcome to a large extent by dividing min LVdP/dt by mean aortic pressure.


Input: Genoa, Italy, 24-28 August 1997.


Input: Electronic structure of delta-plutonium and of single Al, Ga, and Sc impurities in delta-plutonium.


Input: Bound-exciton transfer and photoluminescence undulation spectra for acceptors in ZnTe.


Input: Unified theory of segregated-stack organic charge-transfer solids: Magnetic properties.


Input: II.


Input: Envelope-function matching conditions for GaAs/(Al, Ga) As heterojunctions.


Input: Neutron scattering measurements of critical exponents in CsMnBr3: A Z2 & gt; = 1 antiferromagnet.


Input: Thus, in normal intestinal epithelial goblet cells, TbetaRI and TbetaRII can respond to autocrine but not exogenous TGF-beta without the participation of TbetaRIII.

TbetaRI

TbetaRII

TGF-beta

TbetaRIII


Input: The history of exposure and carboxyhemoglobin levels should alert the physician to this diagnosis.

carboxyhemoglobin


Input: The odds ratio for CHD was 1. 21 (95% confidence interval, 0. 84-1. 75) given a positive serostatus of specific IgG antibodies after adjustment for covariates.

IgG


Input: Another group of HIPP-and HCX-lesioned animals trained on the tasks after the lesion showed reduced impairments of the type described above, suggesting that extrahippocampal structures trained after the lesion can assume the role of the hippocampus to some degree.


Input: The case for neutrinos from SN 1987A.


Input: Scaling of fluctuations in one-dimensional interface and hopping models.


Input: Model of spatiotemporal dynamics of stick-slip motion.


Input: NMR of diffusing atoms in a periodic porous medium in the presence of a nonuniform magnetic field.


Input: Microstructure and conductivity of hierarchical laminate composites.


Input: Anisotropic heat transport in the octylcyanobiphenyl (8CB) liquid crystal.


Input: Direct approach to the study of soliton perturbations.


Input: Mutations affecting only CD4 regulation mapped to residues previously shown to mediate the binding of Nef to this receptor, such as W57 and L58, as well as to an AP-recruiting dileucine motif and to an acidic dipeptide in the C-terminal region of the protein.

Nef

AP-recruiting dileucine motif


Input: The lytic cycle of KSHV, probably under the initial control of the KSHV/Rta gene, may directly contribute to tumor pathogenesis.

KSHV/Rta gene


Input: We conclude that (i) we have identified several candidate latency genes of murine gammaHV68, (ii) expression of genes during latency may be different in different organs, consistent with multiple latency programs and/or multiple cellular sites of latency, and (iii) regions of the viral genome (v-bcl-2 gene, v-GCR gene, and gene 73) are transcribed during latency with both gammaHV68 and primate gammaherpesviruses.

v-bcl-2 gene

v-GCR gene

gene 73


Input: These data indicate a functional role for U1 in NRS-mediated splicing inhibition.

NRS


Input: This suggests that the DcuS-DcuR system responds to external substrates.

DcuS

DcuR


Input: Crossover in the specific heat of dilute magnets induced by critical spin-wave dynamics.


Input: Erratum: Absence of precursor effects above the martensitic transformation in a virgin crystal of Li metal


Input: Interplane coupling in the superconductor Y2Ba4Cu7O15 as revealed by NQR spin-echo double resonance.


Input: Electronic structure of a buried NiSi2 or CoSi2 layer in bulk Si.


Input: Raman investigation of YBa2-xLaxCu3O7 ceramics.


Input: Effects of point defects on lattice parameters of semiconductors.


Input: Chaotic electron dynamics around a single elliptically shaped antidot.


Input: However, deletions of the C terminal 11 or 14 amino acids had more substantial effects.


Input: Sixty months after the initial vaccination, all vaccinees who received annual follow-up still had protective levels of anti-HAV.

anti-HAV


Input: However, after PRK at 5 weeks of age, partial retreatment may be necessary due to regression of the PRK effect.


Input: Its early lesions were characterized by angiomatosis, vasculopathy, and proliferation of synoviocytes and fibroblasts.


Input: Molecular cloning of human cDNA encoding a novel beta1, 6-N-acetylglucosaminyltransferase forming core 2 and core 4.

beta1, 6-N-acetylglucosaminyltransferase


Input: Interspecific mouse back-cross analysis identified the loci for mouse 3Ost genes and syntenic assignments of corresponding human isologs were confirmed by the identification of mapped sequence-tagged site markers.

mouse 3Ost genes


Input: The Scales of Cognitive Impairment Rated From Institutional Records (SCIRFIR), a battery based on commonly used dementia rating instruments, was tested on the records of 26 chronically institutionalized, elderly schizophrenia patients, for the purpose of retrospectively evaluating the long-term course of cognitive change in schizophrenia and relating it to available autopsy materials.


Input: Most recently, the use of the product of brain weight and clearance has been proposed.


Input: Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions.

endogenous Ig heavy chain locus

Ig heavy chain intronic enhancer core region


Input: Two of these motifs are part of a highly conserved and inducible dyad symmetry element shown previously to control a remote IL-2 enhancer and the CD18 promoter.

IL-2 enhancer

CD18 promoter


Input: In concert with the coactivator CREB binding protein/p300, which interacts with GABPalpha, the binding of GABPalpha and-beta to the dyad symmetry element controls the induction of IL-16 promoter in T cells.

CREB binding protein

GABPalpha

GABPalpha and-beta

IL-16 promoter


Input: TPO by itself did not activate ERK1, ERK2 and protein kinase C (PKC), whereas TPO directly enhanced the PKC-dependent activation of ERKs induced by other agonists including thrombin and phorbol esters, without affecting the PKC activation by those agonists.

TPO

protein kinase C

PKC

TPO

PKC

ERKs

thrombin

PKC


Input: BACKGROUND: In the ubiquitin-dependent proteolysis pathway, a ubiquitin ligase (E3) is responsible for substrate selectivity and timing of degradation.

ubiquitin

ubiquitin ligase


Input: CONCLUSIONS: Fission yeast SCF is composed of Pop1 and Pop2, two structurally related but functionally independent F-box/WD-repeat proteins.

Fission yeast SCF

F-box/WD-repeat proteins


Input: 19F NMR studies in ABF4-type layered antiferromagnets.


Input: Optical-absorption spectra, crystal-field energy levels, and transition line strengths of holmium in trigonal Na3


Input: Observation of dipolar interactions between Pb0 defects at the (111) Si/SiO2 interface.


Input: Quantum-statistical theory of high-field transport phenomena.


Input: NH3 and NO interaction with Si (100)-(2 x 1) surfaces.


Input: Far-infrared hopping conductivity in the CuO chains of a single-domain YBa2Cu3O7-delta crystal.


Input: Surface spin waves in a Heisenberg ferrimagnet with a single-ion anisotropy (uniaxial and nonuniaxial).


Input: Multilayer-relaxation geometry and electronic structure of a W (111) surface.


Input: Temperature dependence of the sublattice spontaneous magnetization of YBa2Cu3O6.


Input: GW Gamma approximation for electron self-energies in semiconductors and insulators.


Input: Precision measurement of the pion mass difference m pi--m pi 0.


Input: Testing gravity to second post-Newtonian order: A field-theory approach.


Input: Genetic experiments using mutants defective in apontic and bruno reveal a functional interaction between these genes.

apontic

bruno


Input: In the current model, Wingless/Wnt signal stabilizes Armadillo/beta-catenin, which then accumulates in nuclei and binds TCF/LEF family proteins, forming bipartite transcription factors which activate transcription of Wingless/Wnt responsive genes.

Wingless

Wnt

Armadillo

beta-catenin

TCF

LEF

Wingless

Wnt


Input: In support of clinical antianginal studies, the vasodilator nicorandil (NIC) was combined with the beta-adrenergic receptor antagonists propranolol (PRO) and atenolol (ATN) and with the calcium channel blocker diltiazem (DTZ) to determine their cardiovascular and pharmacokinetic interactions.

beta-adrenergic receptor


Input: Elimination of ETH1 in apn1 strains also increased spontaneous mutation rates 9-or 31-fold compared to the wild type as determined by reversion to adenine or lysine prototrophy, respectively.


Input: Elimination of ETH1 in apn1 strains also increased spontaneous mutation rates 9-or 31-fold compared to the wild type as determined by reversion to adenine or lysine prototrophy, respectively.


Input: Mammalian Ras GTPase-activating protein (GAP), p120 Ras-GAP, has been implicated as both a downregulator and effector of Ras proteins, but its precise role in Ras-mediated signal transduction pathways is unclear.

Ras GTPase-activating protein

GAP

p120 Ras

GAP

Ras proteins

Ras


Input: Three mog-1 alleles possess premature stop codons and are likely to be null alleles, and one is a missense mutation and is likely to retain residual activity. mog-1 mRNA is expressed in both germ line and somatic tissues and appears to be ubiquitous.

mog-1 alleles

mog-1 mRNA


Input: However, unlike the SIN3 gene of Saccharomyces cerevisiae, pst1 (+) is essential for cell viability.

SIN3 gene

pst1 (+)


Input: The Nmd3 protein sequence does not contain readily recognizable motifs of known function.

Nmd3 protein sequence


Input: The distribution of the various repeats suggests its organization is similar to the beta-heterochromatic regions near the base of the major chromosome arms.


Input: Calcitonin simultaneously regulates both periosteal hyperostosis and trabecular osteopenia in the spinal hyperostotic mouse (twy/twy) in vivo.

Calcitonin

twy

twy


Input: In addition, we also show that cdk7 may phosphorylate the carboxy-terminal domain (CTD) of RNA pol II in the absence of promoter opening.

RNA pol II


Input: The therapy with a H2-receptor antagonist is less effective than the triple therapies with omeprazole or lansoprazole.


Input: In humans, three tissue-specific plastin isoforms have been identified.

tissue-specific plastin isoforms


Input: No TATA or Inr sequence was found.


Input: The inhibition by the RIalpha subunit is reversed by addition of nanomolar concentrations of cAMP (Ka = 40 nM), thus demonstrating that PrKX is a novel, type I cAMP-dependent protein kinase that is activated at lower cAMP concentrations than the holoenzyme with the Calpha subunit of cAMP-dependent protein kinase.

RIalpha subunit

PrKX

type I cAMP-dependent protein kinase

Calpha subunit

cAMP-dependent protein kinase


Input: In addition, in vitro mutagenesis of both Engrailed and Pbx1 sites indicated that other unidentified sites are responsible for the transcriptional enhancement observed with the intronic fragment.

Engrailed

Pbx1 sites


Input: Several secondary structure elements were identified.


Input: Here, we evidence that the developmental functions of the family of transcription factors characterized by the POU DNA binding motif exerts roles in mammalian development.

POU DNA binding motif


Input: High-affinity site-specific DNA binding by POU domain transcription factors requires both the POU-specific and the POU-homeodomain.

POU domain transcription factors

POU-specific

POU-homeodomain


Input: In the Oct-1 crystal, the POU-specific domain recognizes a GCAT half-site, while the corresponding sequence recognized by the Pit-1 POU-specific domain, GTAT, is on the opposing strand.

POU-specific domain

Pit-1 POU


Input: Most other end points were highly significant, and death, which was monitored across the U. S. program, was different with p < 0. 0001.


Input: The other is located at-1335, outside this highly conserved region.


Input: Those radiological aspects were distributed in two categories: 1) type I-presenting variable sinusoidal filling.


Input: Results demonstrated that the presence of myofibroblasts varied considerably from case to case and was always related to smooth muscle cell dispersion, which occurred around medium-sized damaged portal vein branches.


Input: Radiative corrections to beta decay and the possibility of a fourth generation.


Input: Depth-controlled grazing-incidence diffraction of synchrotron x radiation.


Input: Oscillatory exchange of atoms between traps containing Bose condensates.


Input: Structure determination of an adsorbate-induced multilayer reconstruction: (1 x 2)-H/Ni (110).


Input: Magnetic trapping of spin-polarized atomic hydrogen.


Input: Northern blot and in situ hybridization analyses revealed GPR34 mRNA transcripts in several human and rat brain regions.

GPR34 mRNA transcripts


Input: The microphthalmia-TFE (MiT) subfamily of basic helix-loop-helix leucine zipper (bHLH-ZIP) transcription factors, including TFE3, TFEB, TFEC, and Mitf, has been implicated in the regulation of tissue-specific gene expression in several cell lineages.

microphthalmia-TFE

MiT

basic helix-loop-helix leucine zipper (bHLH-ZIP) transcription factors

TFEB

TFEC

Mitf


Input: Fifty-seven patients aged < 55 years with acute lymphoblastic leukemia (ALL) in second or third bone marrow (BM) relapse or refractory to first-line therapy were enrolled in an Italian cooperative study.


Input: The dorsal nerves of the penis were anesthetized bilaterally with lidocaine.


Input: Early-onset scleral necrosis after iodine I 125 plaque radiotherapy for ciliochoroidal melanoma.


Input: Successful interaction of ARF and PKC-alpha with PLD1 was not achieved, but a C-terminal fragment of human PLD1 (denoted " D4 ") interacted with the active mutant of RhoA, RhoAVal-14.

ARF

PKC-alpha

human PLD1

RhoA


Input: Vacuum Rabi splitting as a feature of linear-dispersion theory: Analysis and experimental observations.


Input: High-pressure effects on ultrafast-relaxation kinetics of excitons in polydiacetylene 4BCMU.


Input: Drag reduction in turbulent flows by polymers.


Input: Large scale electronic structure calculations.


Input: Current world literature.


Input: These results show that Ski is a component of the HDAC complex and that Ski is required for the transcriptional repression mediated by this complex.

Ski

HDAC complex

Ski


Input: Recombinant unr acts synergistically with recombinant PTB to stimulate translation dependent on the rhinovirus IRES.

unr

PTB


Input: Analysis of the consensus binding sequence and the DNA-binding domain of ZF5.


Input: Mapping of the human Voltage-Dependent Anion Channel isoforms 1 and 2 reconsidered.

human Voltage-Dependent Anion Channel isoforms 1 and 2


Input: Identification of RNase T as a high-copy suppressor of the UV sensitivity associated with single-strand DNA exonuclease deficiency in Escherichia coli.

RNase T

single-strand DNA exonuclease


Input: Inhibition of phosphatidylinositol-3 kinase did not have a significant effect on p53 conformation but did have a weak but significant effect on Tpo-enhanced viability.

phosphatidylinositol-3 kinase

Tpo


Input: No difference in percentage of males in semen production was noted between strains, CP levels, or feeding regimens.


Input: Further analysis of AP-1 DNA binding activities in 7-to 14-day culture activated HSCs led to the discovery of high mobility AP-1 complexes (HMAP-1).

high mobility AP-1 complexes


Input: Mutations of the AP-1 site of the TIMP-1 promoter that prevented formation of HMAP-1 caused a 70% loss of activity in transfected activated HSCs.

AP-1 site

TIMP-1 promoter


Input: STUDY DESIGN: Salivary immunoglobulin A levels of each of 20 subjects were determined on 3 occasions: first, while the subject was still smoking; second, 7 days after cessation of smoking; third, on the 14th day after cessation.

Salivary immunoglobulin A


Input: Role of g2 in relating the Schwinger and Gerasimov-Drell-Hearn sum rules.


Input: Spectroscopy of negative ions utilizing multiphoton detachment in a Raman coupling regime.


Input: Band structure effects of transport properties in icosahedral quasicrystals.


Input: Acoustic transmission spectra in the Penrose lattice.


Input: Two-Channel Kondo Lattice: An Incoherent Metal.


Input: Basal midexpiratory lower esophageal sphincter pressure was similar in the study group (mean [SD] 20. 1 [9. 1] mmHg) and controls (17. 6 [6. 0] mmHg); the pressure did not change following EVS or EVL.


Input: On the other hand, subjects with air trapping (residual volume (RV)/total lung capacity (TLC) > 37%) disclosed not only a higher n (mit) (0. 63 +/-0. 17 versus 0. 43 +/-0. 07 mt x microm (-2), p < 0. 05) but shorter sarcomeres (L (sar)) than subjects without this functional abnormality (2. 08 +/-0. 16 to 2. 27 +/-0. 15 microm, p < 0. 05).


Input: Cyclin D1-associated kinase activity and protein levels were increased in mammary tumors from murine mammary tumor virus-pp60 (c-src527F) transgenic mice.

Cyclin D1-associated kinase


Input: The SH2 domain-containing inositol 5'-phosphatase (SHIP) recruits the p85 subunit of phosphoinositide 3-kinase during FcgammaRIIb1-mediated inhibition of B cell receptor signaling.

SH2 domain-containing inositol 5'-phosphatase

SHIP

p85 subunit

phosphoinositide 3-kinase

B cell receptor


Input: An increase in bone mineral density at the spine, total hip, and total body has been reported with raloxifene but seems to be less than that seen with estrogen or alendronate therapy.


Input: However, in those studies due to the presence of thiol agents in the PKC preparations, the sensitive reaction of BPO with redox-active cysteine residues in PKC was not observed.

PKC

PKC


Input: Interestingly, Csx/Nkx2.

Csx


Input: We also identified an alternative spliced form of Lyp RNA, Lyp2.

Lyp RNA


Input: The costs were DM 11, 562 for a PE, DM 12, 477 for a VR and DM 7, 532 for a MR.


Input: We now provide evidence for physical and functional interaction between Doa4 and the proteasome.


Input: Nipponbare as well as O. australiensis.


Input: In addition, mapping of the promoter region and the identification of putative promoter regulatory sequences should give insight into the transcriptional regulation of UCP2 expression--in particular by anyone of the above mentioned factors--in vitro and in vivo.


Input: The rate of resectability is low and 5-year survival is very poor.


Input: In order to better characterize the distribution of ML and MAP estimates under these conditions, we derive a point approximation to density values of the conditional distribution of such estimates.


Input: RT-PCR was performed using previously reported degenerate oligonucleotide primers to the ligand binding domain (LBD) of known beta integrin subunits and Bge cDNA.

beta integrin subunits

Bge cDNA


Input: The lowest culture failure rate of 0. 2 per cent was found after EAF compared with 0. 9 per cent among CVS.


Input: Ectopic expression of d-axin inhibited Wingless signaling.

d-axin

Wingless


Input: The corresponding differences in FVIIa and PAI-1 were not statistically significant.

FVIIa


Input: On the other side, when the aortic ring was perfused with L-NNA (NO-synthesis inhibitor) or methylene blue (soluble cGMPase inhibitor), the changes could be attenuated.

cGMPase


Input: Nevertheless, inactivation of the cyclin E-Cdk2 complex in response to mitogen starvation occurs normally in MEFs that have a homozygous deletion of the p27 gene.

cyclin E

p27 gene


Input: Identification and characterization of IS2404 and IS2606: two distinct repeated sequences for detection of Mycobacterium ulcerans by PCR.


Input: Taken together, these results are consistent with the possibility that p202 protein contributes to the cell growth retardation activity of the IFNs, at least in part, by modulating p21 protein levels.

p202 protein

IFNs

p21 protein


Input: Similar results were also obtained with a HepG2 hepatoblastoma cell line carrying wt p53.

wt p53


Input: Partial sequencing of the region downstream of ORF-Pto revealed homology to the ru/AB genes, involved in UV resistance, from plasmid pPSR1.

ORF-Pto

ru/AB genes


Input: The MSY2 associated kinase is not casein kinase 2, the kinase believed to phosphorylate mRNP3 + 4 in oocytes, but a yet unidentified kinase.

casein kinase 2

mRNP3 + 4


Input: This suggests that helicase-like genes may be involved in the biosynthesis of nucleic acids and proteins, and that the genes can be transcriptionally activated by heat shock to compensate for the repressed synthesis of mRNA and protein.

helicase-like genes


Input: These data provide the molecular tools for the final identification of the MKS and the MUL genes.

MKS

MUL genes


Input: The origins of reflected light changes associated with neuronal activity (optical signals) were investigated in rat somatosensory cortex with optical imaging, microspectrophotometry, and laser-Doppler flowmetry, and dynamic changes in local hemoglobin concentration and oxygenation were focused on.

hemoglobin


Input: Human neuronal Elav-like proteins contain three RNP-type RNA recognition motifs (RRMs).

Human neuronal Elav-like proteins


Input: Comparison of frequencies of atrial fibrillation after coronary artery bypass grafting with and without the use of cardiopulmonary bypass.


Input: The results of supershift analysis using specific antibodies against transcription factors suggested that both binding complexes contained the NF-kappaB components p50 and p65, and did not contain other NF-kappaB proteins (p52, c-Rel, Rel B), AP-1 proteins (c-Fos, C-Jun), CREB or C/EBPbeta (NF-IL6).

NF-kappaB

NF-kappaB proteins

c-Rel

Rel B

AP-1 proteins

c-Fos

C-Jun

CREB

C/EBPbeta


Input: A set of peptides corresponding to the individual elements of secondary structure derived from the N-terminal domain of the ribosomal protein L9 have been synthesized.

ribosomal protein L9


Input: The results showed that IFN-gamma stimulated the rapid accumulation of interferon regulated factor (IRF)-1 mRNA, followed by a delayed and dose-dependent inhibition of alpha1 (I) procollagen mRNA expression in skin fibroblasts from several different donors.

IFN-gamma

interferon regulated factor (IRF)-1 mRNA

alpha1 (I) procollagen mRNA


Input: Functional domains of c-myc promoter binding protein 1 involved in transcriptional repression and cell growth regulation.

c-myc promoter binding protein 1


Input: Therefore, we have named this gene UBP43.


Input: These results continue to support the hypothesis that HS2, HS3, and HS4 act as a single, integral unit to regulate human globin gene transcription as a holocomplex, but they can also be interpreted to say that formation of a DNase I hypersensitive holocomplex alone is not sufficient for mediating high-level globin gene transcription.

human globin gene

DNase I

globin gene


Input: Because there is great need for iron in the EPO-stimulated erythroid progenitors, it is essential that serum ferritin and transferrin saturation levels should be maintained over 300 microg/liter and 30%, respectively.

EPO

serum ferritin

transferrin


Input: These results indicate that the p33 subunit of eIF3 plays an important role in the initiation phase of protein synthesis and that its RNA-binding domain is required for optimal activity.

p33 subunit


Input: KEY WORDS: Melaleuca; Lake Okeechobee; Littoral zone; Water level; Regulation schedule


Input: The systolic peak of pulmonary vein was higher than the diastolic peak in 45 out of 56 cases.


Input: Specimens were assayed for alpha-fetoprotein, unconjugated estriol, free alpha hCG, and total hCG.

alpha-fetoprotein

alpha hCG

hCG


Input: The following data were recorded at arrival in the intensive care unit 6, 12, 24, and 48 hours after termination of CPB: heart rate, blood pressure, left atrial pressure, central-peripheral temperature difference, arterial-central venous oxygen saturation difference, urine output, serum creatinine, lactate and neutrophil elastase levels, the Doppler echocardiographic factors shortening fraction and preejection period/left-ventricular ejection time, and cumulative doses of catecholamines (epinephrine), enoximone, and furosemide.

neutrophil elastase


Input: MDS1/EVI1, located on chromosome 3 band q26, encodes a zinc-finger DNA-binding transcription activator not detected in normal hematopoietic cells but expressed in several normal tissues.

zinc-finger DNA-binding transcription activator


Input: The JTc delta among the three groups did not differ as well: JTc delta of the VT group was 70 ms +/-30 ms, the JTc delta of the PVC group was 60 msec +/-25 msec, and the JTc delta of the control group was 70 ms +/-30 ms.


Input: In contrast, deletion of the upstream portion of the delta promoter led to a 10 fold decrease in expression.


Input: Site-directed mutagenesis of binding sites for the repressor proteins BP1 and BP2 in the upstream portion of the beta globin gene flanking region led to a 4-6 fold increase in promoter activity.

repressor proteins BP1

beta globin gene flanking region


Input: However, with the alpha1 antagonist prazosin (5 x 10 (-8)-5 x 10 (-7) M), no relaxation occurred.


Input: Differential expression of AP-2alpha and AP-2beta in the developing chick retina: repression of R-FABP promoter activity by AP-2.

R-FABP promoter


Input: The mean value of the CD79b to the CD79b internally deleted ratio was 0. 64 +/-0. 20 SD in normal donors and 0. 44 +/-0. 27 SD in B-CLL (P =. 01).


Input: As normal B cells also present this variant, the mechanism of CD79b posttranscriptional regulation might reflect the activation stage of the normal B cell from which B-CLL derives.


Input: High-level gains (HLGs) indicative of gene amplifications were identified at 11q13 in two cases, and in one case each at 2q33-34, 3q25-29, 5p15. 1-15. 2, 7q21-22, 11p11. 2, 12p11. 2-12, and 13q34.


Input: With respect to the distribution of active MREs over the promoter region, the hMT-IIA gene is largely different from the mouse metallothionein-I gene, suggesting that MRE arrangement is not an important factor for metal regulation.

hMT-IIA gene

metallothionein-I gene


Input: The cDNA was expressed in Saccharomyces cerevisiae under the control of the yeast triose phosphate isomerase promoter.

yeast triose phosphate isomerase promoter


Input: Interestingly, the RNA sequences selected by the mutated zinc knuckle 9G8 variant are efficiently recognized by SRp20, in agreement with the fact that the RBD of 9G8 and SRp20 are similar.

zinc knuckle 9G8 variant


Input: Topoisomerase II is a major target of the protein kinase casein kinase 2 (PK CK2) in vivo.

Topoisomerase II

protein kinase casein kinase 2

PK CK2


Input: Recent work in this laboratory has shown that the gene coding for acetate kinase (ackA) in Sinorhizobium meliloti is up-regulated in response to phosphate limitation.

acetate kinase

ackA


Input: All numbers refer to nucleotide positions on the wild-type HIV-1 transcript.


Input: Here, we report the complete structure of the human topoisomerase IIalpha gene, which consists of 35 exons spanning 27. 5 kb.

human topoisomerase IIalpha gene


Input: Previous studies characterized a cytokine-inducible, functional nuclear factor (NF)-kappaB consensus element in the immediate 5' regulatory region of the MGSA/GRO-alpha gene at-78 bp.

nuclear factor (NF)-kappaB consensus element

MGSA

GRO-alpha


Input: An exon that prevents transport of a mature mRNA.


Input: Four CsA-treated patients developed persistently elevated UAER > 30 mg/24 h (n = 3 with microalbuminuria), whereas all the 17 placebo-treated patients had normal UAER (< 30 mg/24 h) after 7 years of follow-up.


Input: Mutational analysis of the-84/-55 DNA showed that JEG-3 nuclear proteins bound to a site containing, but not identical to, the SF-1 sequence.

SF-1 sequence


Input: In contrast, no change was detected in the phenotype of' unstressed' clones, with respect to any of the following parameters: proliferation rate in monolayer, serum-dependence for proliferation or survival, tumorigenicity, cellular morphology, or tissue-specific differentiation markers.


Input: A high reactor pH (+/-8), a short solid retention time (< 150 days), and the presence of a substantial SRB population in the inoculum may considerably reduce the time required for acetate-utilising SRB to outcompete MB.


Input: In throttling valves, the aim is to correlate the effect of shear to a parameter related to the inner geometry of the valve and to operating conditions.


Input: A mutation linked to the SOC1 gene, previously defined by recessive mutations that suppress cbp1 ts alleles and stabilize many mitochondrial mRNAs, was also isolated.

SOC1 gene

cbp1 ts alleles


Input: A deletion mutation analysis of the recombinant protein has shown that the N-terminal region and the two leucine zippers are necessary for the binding.


Input: A database search has revealed as the most significative homology a match with the human mitochondrial transcription termination factor (mTERF), a protein that also binds DNA as a monomer and contains three leucine zippers forming intramolecular interactions.

human mitochondrial transcription termination factor

mTERF


Input: In all trials, antigen challenge followed 1 h after the last treatment.


Input: 31, 1997, 40 patients had died (35 in the ERA-II group and 5 in the ERA-III group), for a crude mortality rate of 8. 0%.


Input: We found that total PSA can be detected in all cyst fluids and in about 75% of female sera.

PSA


Input: Type I cysts (with a high K +/Na + ratio) tend to have higher total PSA than Type II cysts.

PSA


Input: Despite this DNA binding activity, AP-1 reporter activity was suppressed in these cells.

AP-1 reporter


Input: A single N-glycosylation site present in chicken gp42 is conserved among all five of these proteins: carbohydrate analysis of gp42 revealed the presence of a complex type glycan chain at this site.

chicken gp42


Input: Here we describe the optimization and characterization of a 140-residue fragment, containing the Runt domain of AML1, which is suitable for structural studies.

Runt domain


Input: Judge OKs docs' bid for Chicago hospital.


Input: HANYS criticizes laparoscopic gall bladder guidelines.


Input: Groups dicker for price breaks as anesthetic gas goes multi-source.


Input: Troubled CareNetwork gets pact from largest teacher union in Wis.


Input: Ultrasonography provides excellent intraoperative evaluation of spinal cord injury.


Input: UPMC is not the only organization pursuing controlled NHBC organ procurement, however.


Input: Because of concerns regarding blood transfusion-related communicable disease (eg, acquired immune deficiency syndrome and non-A, non-B hepatitis), there has been increasing research effort into postoperative hemorrhage related to cardiopulmonary bypass with extracorporeal circulation.


Input: They contrast trends in fertility, life expectancy ratios, and gender differences in these countries with the Hispanic population of the United States.


Input: Holger v.


Input: Hospital hit for hiring AHERF physicians.


Input: Overexpression of either DAP-1 or sentrin causes apoptosis of TNF-sensitive L929 fibroblast cell line, as well as TNF-resistant osteosarcoma cell line, U2OS.

sentrin

TNF

TNF


Input: This is in contrast to PPARgamma2, which was previously shown to be phosphorylated at a single site in a motif that is not homologous to the sites now described in PPARalpha.

PPARalpha


Input: These results suggest KCC3 is a new member of the KCC family that is under distinct regulation from KCC1.

KCC family


Input: We have screened the elastin gene for mutations responsible for supravalvular aortic stenosis (SVAS) in two large, independently collected families with isolated (nonsyndromic) SVAS.

elastin gene


Input: Spatiotemporal expression of the PAX3 gene is tightly regulated during development.

PAX3 gene


Input: A list of 12 names for the disease and 37 diagnostic criteria were proposed to a Consensus Panel of 12 Italian experts who ranked them in order so as to identify a core set of criteria.


Input: Methanesulfonyl fluoride (MSF): a double-blind, placebo-controlled study of safety and efficacy in the treatment of senile dementia of the Alzheimer type.


Input: METHODS: Between August 1991 and June 1994, 198 men with clinical T2 or T3 classified (TNM) prostate carcinoma (bone scan negative) who were at high risk of lymph node involvement underwent a 111In-capromab pendetide scan prior to staging lymphadenectomy.


Input: Voluntary wheel running did not significantly increase estimated alanine or pyruvate Gneo or absolute glycerol Ra.


Input: Immediately after surgery, dialysate PGE2 and adenosine concentrations were 3. 7 +/-0. 7 and 296 +/-127 nM, respectively.


Input: Because of the probable causal relationship between constitutive p210 (bcr/abl) protein tyrosine kinase activity and manifestations of chronic-phase chronic myelogenous leukemia (CML; myeloid expansion), a key goal is to identify relevant p210 substrates in primary chronic-phase CML hematopoietic progenitor cells.

bcr

abl

protein tyrosine kinase


Input: In vitro precipitation with a glutathione-S-transferase-fusion protein containing the C-terminal transactivation domain of STAT5a showed GH-regulated association of ERK1/2 with the fusion protein, while this was not seen when serine 780 in STAT5a was changed to alanine.

glutathione-S-transferase-fusion protein

GH


Input: One such element, 1P, was employed to clone from a rat pituitary cDNA expression library a novel 417-amino acid WD protein, designated PREB (PRL regulatory element binding) protein.

417-amino acid WD protein

PREB (PRL regulatory element binding) protein


Input: Characterization of the transcription factor MTF-1 from the Japanese pufferfish (Fugu rubripes) reveals evolutionary conservation of heavy metal stress response.

transcription factor MTF-1


Input: The peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily.

peroxisome proliferator-activated receptors

PPARs

nuclear hormone receptor superfamily


Input: However, F-SRC-1 mutant lacking CBP-interacting domain still preserved enhancing activity.

F-SRC-1 mutant

CBP-interacting domain


Input: The catalytic site has an S1 pocket lined with conserved hydrophobic residues to accommodate the pyroglutamyl residue.


Input: The complete circular TTV genome contained a novel sequence of 113 nt (nt 3740 to 3852 [= 0]) in between the known 3'-and 5'-end arms, forming a 117-nt GC-rich stretch (GC content, 90. 6% at nt 3736 to 3852).


Input: The Asian mouse Mus castaneus is resistant to infection by the polytropic mink cell focus-inducing (MCF) subgroup of murine leukemia viruses (MuLVs).


Input: To determine the function of VZV gK in virus growth, a series of gK deletion mutants were constructed with VZV cosmid DNA derived from the Oka strain.

VZV gK

gK deletion mutants


Input: CCAAT displacement protein binds to and negatively regulates human papillomavirus type 6 E6, E7, and E1 promoters.

CCAAT displacement protein


Input: Three different site-directed mutations of the cyclic AMP response element each reduced the nerve growth factor effect by > 90%.

nerve growth factor


Input: Using an RNase H protection assay and specific blocking oligonucleotides, we find that recognition of the 5' splice-site (5' ss) and branchpoint sequence (BPS) elements by U11 and U12 snRNPs, respectively, displays strong cooperativity, requiring both sites in the pre-mRNA substrate for efficient complex formation.

RNase H

U12 snRNPs


Input: Many eukaryotic cell surface proteins are anchored in the lipid bilayer through glycosylphosphatidylinositol (GPI).


Input: An endogenous mammalian regulator of this process, named Usurpin, has been identified (aliases for Usurpin include CASH, Casper, CLARP, FLAME-1, FLIP, I-FLICE and MRIT).

Usurpin

Usurpin

CASH

Casper

CLARP

FLIP

I-FLICE

MRIT


Input: Plasma glucose, immunoreactive insulin (IRI), C-peptide, glucagon, and GLP-1 levels at each time point during OGTT were measured.

immunoreactive insulin

IRI

C-peptide

glucagon


Input: Technetium-99m methylene diphosphonate scintimammography for evaluation of palpable breast masses.


Input: Nuclear receptors (NRs) can function as ligandinducible transregulators in both mammalian and yeast cells, indicating that important features of transcriptional control have been conserved throughout evolution.


Input: When tethered to a heterologous DNA-binding domain, PSU1 can activate transcription on its own.


Input: OBJECTIVE: To follow-up prospectively patients with arthritis after infection with beta-haemolytic streptococci of Lancefield group A (beta HSA), with emphasis on clinical characteristics and serological features.


Input: We found that the expression of the protein was maximum in mitosis and minimum in G1, which correlated with the expression of its messenger RNA.


Input: These findings demonstrate that signature-tagged mutagenesis is a viable approach to identify bacterial genes associated with the ability to infect the urinary tract.


Input: Pathol.


Input: The eukaryotic cell cycle is governed in part by the periodic transcription of cyclin genes, whose protein products associate with and positively regulate the cyclin-dependent kinases.

cyclin genes

cyclin-dependent kinases


Input: The GAC1 gene encodes the regulatory subunit for a type 1 serine/threonine phosphoprotein phosphatase, Glc7.

GAC1 gene

type 1 serine/threonine phosphoprotein phosphatase


Input: The results demonstrate that the Glc7 phosphatase and its Gac1 regulatory subunit play positive roles in HSF activation of CUP1 transcription.

Glc7 phosphatase

HSF


Input: MEF and AML1B synergistically transactivated an interleukin 3 promoter reporter gene construct, yet the activating activity of MEF was abolished when MEF was coexpressed with AML1/ETO.

MEF

interleukin 3 promoter reporter gene construct

MEF

MEF

ETO


Input: Mechanistically, the presence of the GRR appears to stop further degradation of p50 and to stabilize the molecule.


Input: This phosphorylation can be catalyzed by a break-ended double-stranded DNA-activated protein kinase activity from the sea urchin nucleus in vitro.


Input: Concomitantly, the total cellular level of p21 increased severalfold via a posttranscriptional mechanism.


Input: Moreover, when added to the osteoclast cultures, mrIhh-N markedly stimulated the formation of resorption pits on dentine slices.

mrIhh-N


Input: Overall, our results suggest that resistant genotypes exist among the WAD goat population.


Input: The molecular mechanism by which Gle2p and the Gle2p-Nup116p interaction function in mRNA export is unknown.


Input: The Fyn NH2 terminus was necessary but not sufficient for interaction with zeta and both Fyn kinase and SH2 domains were required, directing phosphorylation of zeta ITAM tyrosines and binding to zeta ITAM phosphotyrosines.

Fyn NH2 terminus

Fyn kinase

SH2 domains

zeta ITAM

zeta ITAM


Input: In budding yeast, the protein Skp1p, the cullin-family member Cdc53p, and the F-box/WD-repeat protein Cdc4p form the SCFCdc4p ubiquitin ligase complex, which targets the cyclin-dependent kinase (Cdk) inhibitor Sic1p for proteolysis [3] [4] [5] [6] [7] [8].

cullin-family member Cdc53p

SCFCdc4p ubiquitin ligase

cyclin-dependent kinase

Cdk


Input: We show here that, despite their structural and functional similarities, the pop1 and pop2 genes fail to complement each other' s deletion phenotypes, indicating that they perform non-redundant, but potentially interdependent, functions in proteolysis.

pop2 genes


Input: Antithrombin III prevents 60 min warm intestinal ischemia reperfusion injury in rats.

Antithrombin III


Input: In retrospect, the diagnoses were reconsidered applying strict criteria.


Input: These observations of elevated serum lipase and serum CA 19-9 in Sjogren' s syndrome without evidence of malignancy may reflect pancreatic involvement in this disorder.

serum lipase

CA 19-9


Input: Acute pancreatitis as a complication of polyarteritis nodosa.


Input: Significantly greater improvement (p < 0. 05) in the sertraline group first became apparent by the end of week 3 on the Y-BOCS and the CGI Improvement scale, and by the end of weeks 6 and 8, respectively, on the NIMH and CGI Severity scale.


Input: Stress-inducible protein kinases capable of activating c-jun expression include stress-activated protein kinase/c-Jun N-terminal protein kinase (SAPK/JNK) and p38 members of the mitogen-activated protein kinase (MAPK) superfamily of signaling molecules.

Stress-inducible protein kinases

c-jun

stress-activated protein kinase

c-Jun N-terminal protein kinase

SAPK

JNK

mitogen-activated protein kinase

MAPK


Input: Transforming growth factor (TGF)-beta1 induces extracellular matrix deposition and proliferation of mesenchymal cells.

Transforming growth factor (TGF)-beta1


Input: Chronotherapeutics in cardiovascular disease.


Input: Group psychometric functions for listeners with hearing loss do not show a decrease in performance at the largest values of delta f included in this study.


Input: Uroflowmetry can detect dysuria, which may be poorly perceived or even unknown to the subjects themselves.


Input: Marked racial variation in birthweight percentiles by gestational age was evident.


Input: Significant correlations between mental status as measured by the Mini-Mental State Examination and NA/mI, mI/Cr and NA were found.


Input: Glucagon also induced LUC activity very strongly when the CRE1 and CRE2 sites were combined; induction of the (CRE1) 3 (CRE2) 2SV40-LUC constructs was positively modulated by the pO2.

Glucagon

LUC

LUC


Input: In this study, we report the isolation and characterization of the entire rat GSTA3 (rGST Yc1) subunit gene.

rat GSTA3

rGST Yc1


Input: Calcinosis cutis following intravenous infusion of calcium gluconate.


Input: Finally, we determined the genomic organization of the human TrxR2 gene, which consists of 18 exons spanning about 67 kb, and its chromosomal localization at position 22q11. 2.

human TrxR2 gene


Input: The aims of this study were to determine and rank the frequency of self reported visual disability in daily tasks performed by glaucoma patients; to examine the interrelation between disabilities using factor analysis; to study the relation between perceived visual difficulty and a measure of the severity of visual field loss; to develop a glaucoma specific subgroup of questions; and examine the validity and reliability of this subgroup of questions.


Input: Furthermore, the validity of this new subset of questions was shown to be significant (r = 0. 037, p < 0. 05) for the correlation between a measure of the severity of binocular visual field loss and the mean score of the variables used in the glaucoma specific subgroup of questions.


Input: Sequence comparison of cytochromes bd and their homologs from various organisms demonstrates that the proteins can be classified into two subfamilies, a proteobacterial type including E. coli bd and a more widely distributed type including the B. stearothermophilus enzyme, suggesting that the latter type is evolutionarily older.

cytochromes bd

E. coli bd


Input: In 11 eyes that had been selected at random 10 micrograms of recombinant tissue plasminogen activator were injected midvitreally 24 hrs later.

recombinant tissue plasminogen activator


Input: RESULTS AND CONCLUSIONS: Brandt' s double cuff-tubes (G2) succeed in avoiding uncontrolled increase of cuff-pressure during anaesthesia with N2O.


Input: Accordingly, we designated this gene CTL1 (capping enzyme RNAtriphosphatase-like 1).

gene CTL1

capping enzyme RNAtriphosphatase-like 1


Input: Their afterglows are brighter than supernovae and therefore are called hypernovae.


Input: Constrictive pericarditis and pleuropulmonary disease linked to ergot dopamine agonist therapy (cabergoline) for Parkinson' s disease.


Input: An undilated type of APBD is frequently associated with AMT and we believe, therefore, that clinicians should be aware of a possible coexistence of APBD and AMT.


Input: In addition, we also constructed and expressed chimeric fusion protein that contains HIV-2 gag with V3 domains of HIV-1IIIB, HIV-1MN, HIV-1SF2 and HIV-1RF.

HIV-2 gag


Input: Our results indicate that V3 peptides from all major clades of HIV-1 carried by HIV-2 gag can be used as a potential HIV/AIDS vaccine.

HIV-2 gag


Input: Efficacy was determined by responses to question 3 (ability to achieve an erection) and question 4 (ability to maintain an erection) of the 15-item International Index of Erectile Function (IIEF).