{"input": "Comparison with alkaline phosphatases and 5-nucleotidase", "output": {"entities": {"gene": [{"text": "alkaline phosphatases", "start": 16, "end": 37}]}}, "schema": []}
{"input": "Pharmacologic aspects of neonatal hyperbilirubinemia.", "output": {"entities": {}}, "schema": []}
{"input": "When CSF [HCO3-] is shown as a function of CSF PCO2 the data of K-depleted rats are no longer displaced when compared to controls but still have a significantly greater slope (1. 21 +/-0. 23 vs.", "output": {"entities": {}}, "schema": []}
{"input": "Flurazepam thus appears to be an effective hypnotic drug with the optimum dose for use in general practice being 15 mg at night.", "output": {"entities": {}}, "schema": []}
{"input": "Beta blocking agents.", "output": {"entities": {}}, "schema": []}
{"input": "When extracorporeal CO2 removal approximated CO2 production (VCO2), alveolar ventilation almost ceased.", "output": {"entities": {}}, "schema": []}
{"input": "Intravenous administration (25 mg/kg) of carbonic anhydrase inhibitors (acetazolamide, methazolamide, dichlorphenamide, sulthiame) induced an early important rise of cortical p O2, which is not dependent on increase of p O2 and p CO2 and decrease of pH in arterial blood.", "output": {"entities": {"gene": [{"text": "carbonic anhydrase", "start": 41, "end": 59}]}}, "schema": []}
{"input": "Teratological study of etoperidone in the rat and rabbit.", "output": {"entities": {}}, "schema": []}
{"input": "Colorectal polyps should be removed endoscopically whenever possible.", "output": {"entities": {}}, "schema": []}
{"input": "The variable HMG dosage regimen was found to offer no advantages when compared with our standard daily dosage regimen.", "output": {"entities": {"gene": [{"text": "HMG", "start": 13, "end": 16}]}}, "schema": []}
{"input": "When the CO2 content reached 9 Vol% the animals became apathic and lost body weight.", "output": {"entities": {}}, "schema": []}
{"input": "Serum gamma glutamyltransferase in the diagnosis of liver disease in cattle.", "output": {"entities": {"gene": [{"text": "Serum gamma glutamyltransferase", "start": 0, "end": 31}]}}, "schema": []}
{"input": "By contrast, secretory HI antibodies were not demonstrated at the onset of illness in any of the patients, but their formation started early and the antibodies reached maximal levels about 10 days after onset of illness.", "output": {"entities": {"gene": [{"text": "secretory HI antibodies", "start": 13, "end": 36}]}}, "schema": []}
{"input": "With the exception of virus assay and quantitation, these methods are simple and inexpensive enough to be done in typical shellfish microbiology laboratories.", "output": {"entities": {}}, "schema": []}
{"input": "Characteristics of lipase activity.", "output": {"entities": {"gene": [{"text": "lipase", "start": 19, "end": 25}]}}, "schema": []}
{"input": "Takayasu' s disease: association with HLA-B5.", "output": {"entities": {"gene": [{"text": "HLA-B5", "start": 38, "end": 44}]}}, "schema": []}
{"input": "SGPT, SGOT, and alkaline phosphatase concentrations were essentially normal in all subjects.", "output": {"entities": {"gene": [{"text": "SGPT", "start": 0, "end": 4}, {"text": "SGOT", "start": 6, "end": 10}, {"text": "alkaline phosphatase", "start": 16, "end": 36}]}}, "schema": []}
{"input": "Gamma glutamyl transpeptidase (GGTP) activity in the seminal fluid", "output": {"entities": {"gene": [{"text": "Gamma glutamyl transpeptidase", "start": 0, "end": 29}, {"text": "GGTP", "start": 31, "end": 35}]}}, "schema": []}
{"input": "Patients with Parkinson' s disease showed a relatively high incidence to psychoses during drug treatment (51. 47%).", "output": {"entities": {}}, "schema": []}
{"input": "Selective stimulation of central alpha-autoreceptors following treatment with alpha-methyldopa and FLA 136.", "output": {"entities": {"gene": [{"text": "alpha-autoreceptors", "start": 33, "end": 52}]}}, "schema": []}
{"input": "Anti-anxiety action of diazepam after intra-amygdaloid application in the rat.", "output": {"entities": {}}, "schema": []}
{"input": "Abstracts.", "output": {"entities": {}}, "schema": []}
{"input": "Removal of thick, permanently altered mucoas is recommended even in the absence of squamous epithelium.", "output": {"entities": {}}, "schema": []}
{"input": "An IgG monoclonal gammopathy was present in the serum of 4 patients and Bence-Joanes proteinuria was found in 1 patient.", "output": {"entities": {"gene": [{"text": "IgG", "start": 3, "end": 6}]}}, "schema": []}
{"input": "Studies on immunoglobulin E: the impact of a sojourn with Professor Dan H.", "output": {"entities": {"gene": [{"text": "immunoglobulin E", "start": 11, "end": 27}]}}, "schema": []}
{"input": "Peroxydase reaction stains were negative, chloroacetate esterase were strongly positive.", "output": {"entities": {"gene": [{"text": "Peroxydase", "start": 0, "end": 10}, {"text": "chloroacetate esterase", "start": 42, "end": 64}]}}, "schema": []}
{"input": "Ten out-patients with pustulosis palmaris et plantaris were examined with direct immunofluorescence (IF) technique for deposition of fibrinogen, fibrin or its degradation products (FR-antigen) in affected and unaffected skin, together with heparin-precipitable fraction (HPF), cryoglobulin and total plasma fibrinogen in the blood.", "output": {"entities": {"gene": [{"text": "fibrinogen", "start": 133, "end": 143}, {"text": "fibrin", "start": 145, "end": 151}, {"text": "FR-antigen", "start": 181, "end": 191}, {"text": "cryoglobulin", "start": 277, "end": 289}, {"text": "fibrinogen", "start": 307, "end": 317}]}}, "schema": []}
{"input": "Of 600 mediastinoscopies carried out from 1966 to 1973, 479 were performed to assess the operability of a pulmonary carcinoma.", "output": {"entities": {}}, "schema": []}
{"input": "A mixture of human albumin 5% and hydroxy-ethyl-starch was used as a solution for dilution.", "output": {"entities": {"gene": [{"text": "human albumin", "start": 13, "end": 26}]}}, "schema": []}
{"input": "In the matched control group the acquisition-rate of both symptomatic and asymptomatic 0acteriuria was over 12%, a figure similar to the percentage of women present in the practice population during one year with transient, symptomatic, and persistent A. B.", "output": {"entities": {}}, "schema": []}
{"input": "Late complications of catheterisation for intravenous nutrition.", "output": {"entities": {}}, "schema": []}
{"input": "Prenatal diagnosis of galactosaemia.", "output": {"entities": {}}, "schema": []}
{"input": "Sings which are indicative of metaplastic erythropoiesis are absent.", "output": {"entities": {}}, "schema": []}
{"input": "False positive amniotic fluid alpha fetoprotein levels resulting from contamination with fetal blood: results of an experiment.", "output": {"entities": {"gene": [{"text": "amniotic fluid alpha fetoprotein", "start": 15, "end": 47}]}}, "schema": []}
{"input": "Serum-ferritin in diagnosis of haemochromatosis.", "output": {"entities": {"gene": [{"text": "ferritin", "start": 6, "end": 14}]}}, "schema": []}
{"input": "In 2 subjects the phytomitogen reactivity of the lymphocytes was improved after treatment.", "output": {"entities": {}}, "schema": []}
{"input": "Patients at risk of hypothyroidism.", "output": {"entities": {}}, "schema": []}
{"input": "Albumin and cyclic AMP levels in peritoneal fluids in the child", "output": {"entities": {"gene": [{"text": "Albumin", "start": 0, "end": 7}]}}, "schema": []}
{"input": "Preface.", "output": {"entities": {}}, "schema": []}
{"input": "Thirty-five strains of Legionnaires' disease bacteria were shown to belong in four distinct serologic groups on the basis of findings obtained with direct fluorescent antibody testing.", "output": {"entities": {}}, "schema": []}
{"input": "On the other hand factor IX activity is decreased in coumarin treatment with factor IX antigen remaining normal.", "output": {"entities": {"gene": [{"text": "factor IX", "start": 18, "end": 27}, {"text": "factor IX", "start": 77, "end": 86}]}}, "schema": []}
{"input": "The concentration of alpha 2-macroglobulin, alpha 1-antitrypsin, plasminogen, C3-complement, fibrinogen degradation products (FDP) and fibrinolytic activity, were studied in the aqueous humour and serum from nine patients with Fuchs' endothelial dystrophy, 17 patients with uncomplicated senile cataract and in the secondary aqueous from six cataract patients.", "output": {"entities": {"gene": [{"text": "alpha 2-macroglobulin", "start": 21, "end": 42}, {"text": "alpha 1-antitrypsin", "start": 44, "end": 63}, {"text": "plasminogen", "start": 65, "end": 76}, {"text": "C3-complement", "start": 78, "end": 91}, {"text": "fibrinogen degradation products", "start": 93, "end": 124}, {"text": "FDP", "start": 126, "end": 129}]}}, "schema": []}
{"input": "Only 17% of all patients admitted it at all times.", "output": {"entities": {}}, "schema": []}
{"input": "Prazosin alone was effective in volume responsive patients at a dose of 5 +/-1. 0 mg daily.", "output": {"entities": {}}, "schema": []}
{"input": "T4 and FT4I followed parallel courses in both groups; during the first 45 days, however, the values were significantly lower in premature infants under 34 weeks' EGA than in term infants (P less than 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "A three-phased analysis of treatment plans for 45 patients was undertaken.", "output": {"entities": {}}, "schema": []}
{"input": "Aspirin intolerance: unaltered susceptibility of platelet cyclo-oxygenase to inhibition by aspirin in vitro.", "output": {"entities": {"gene": [{"text": "platelet cyclo-oxygenase", "start": 49, "end": 73}]}}, "schema": []}
{"input": "These results indicate that cynomolgus monkeys are either less sensitive or respond differently than rhesus monkeys to some of the pharmacological effects of norcocaine.", "output": {"entities": {}}, "schema": []}
{"input": "59 cases of surgically resectable cancers (T1, T2, T3, N0, N1) had a minimum followup of two years (average 4 years +/-3 months).", "output": {"entities": {}}, "schema": []}
{"input": "The effect of CBZ and DPH can be explained by interference with thyroid hormone binding to TBG combined with enzyme-induced increased metabolic clearance rate of thyroid hormones without homeostatic maintenance of premedication levels of FT4 and FT3.", "output": {"entities": {"gene": [{"text": "TBG", "start": 91, "end": 94}]}}, "schema": []}
{"input": "The present research evaluated the possibility that polyethylene glycol 400 (PEG 400) might be efficacious, toxic, or both.", "output": {"entities": {}}, "schema": []}
{"input": "According to their functional properties the latter neurons were subdivided into: (a) neurons responding to stimuli near the eyes; (b) neurons triggered by complex visual stimuli; (c) neurons inhibited by visual stimuli.", "output": {"entities": {}}, "schema": []}
{"input": "Pentobarbital (1, 3, 10, and 17. 5 mg/kg) was also tested in combination with rate-decreasing doses of normeperidine (17. 5 mg/kg), anileridine (10 mg/kg), alphaprodine (10 mg/kg), and fentanyl (0. 3 mg/kg).", "output": {"entities": {}}, "schema": []}
{"input": "Pb foil (0. 55 gcm-2) provided the best overall improvement.", "output": {"entities": {}}, "schema": []}
{"input": "An anatomical and histochemical study has been undertaken and as a result emphasis is given to recent hypotheses that suggest there are similarities with Type IV glycogen storage disease (Andersen' s disease) which, although clinically distinct, has the same enzyme defect.", "output": {"entities": {}}, "schema": []}
{"input": "All groups were tested in a Hebb-Williams maze at 100 approximately 10 days of age.", "output": {"entities": {}}, "schema": []}
{"input": "Erythromycin and clindamycin resistance in Corynebacterium diphtheriae from skin lesions.", "output": {"entities": {}}, "schema": []}
{"input": "Imposed angular displacements of monkey' s wrist produce three major peaks of activity (terms M1, M2, and M3 peaks) in the averaged gross EMG activity ot the stretched muscles.", "output": {"entities": {}}, "schema": []}
{"input": "Hemolytic disease of African newborn.", "output": {"entities": {}}, "schema": []}
{"input": "In this animal, infected with what was judged previously to be the less virulent of the two T. cruzi stocks used (' strain 7'), there was severe myocarditis, with myofibre degeneration, and lesions of the oesophagus.", "output": {"entities": {}}, "schema": []}
{"input": "The majority of MRF units were behaviorally incongruent; in the most frequently observed case, their activity failed to change reliably when behavior habituated.", "output": {"entities": {}}, "schema": []}
{"input": "Variability within Down' s syndrome (trisomy-21): empirically observed sex differences in IQs.", "output": {"entities": {}}, "schema": []}
{"input": "VII.", "output": {"entities": {}}, "schema": []}
{"input": "Several demographic indices of isolated populations in Uzbekistan", "output": {"entities": {}}, "schema": []}
{"input": "2.--concepts of higher nervous function in the USSR.", "output": {"entities": {}}, "schema": []}
{"input": "The maintenance of increased myocardial capillary density required a similar amount of exercise, and at least 1 h of exercise once a week was necessary to maintain the enlargement of ECA. 20", "output": {"entities": {}}, "schema": []}
{"input": "These observations have led us to conclude that an elevated VIII-ratio is a very sensitive indicator of intravascular coagulation.", "output": {"entities": {}}, "schema": []}
{"input": "Eight hours after the administration of colchicine, the serum ceruloplasmin level began to rise again in female rats, but not in male rats.", "output": {"entities": {"gene": [{"text": "serum ceruloplasmin", "start": 56, "end": 75}]}}, "schema": []}
{"input": "Radioimmunoassays of pregnenolone, progesterone, dehydroepiandrosterone (DHA) 16 alpha-hydroxy-DHA, estriol, and cortisol were performed on a total of 0; 1 ml; of fetal plasma, collected during the course of normal vaginal delivery.", "output": {"entities": {}}, "schema": []}
{"input": "In only two patients were we able to demonstrate changes suggestive of pulmonary metastases any earlier with a 99mTc-EHDP scan than with chest radiographs and one of these resolved spontaneously.", "output": {"entities": {}}, "schema": []}
{"input": "The majority of tumors occurred in the nasal cavities, although significant incidences were also found in the larynx, trachea and stem bronchi.", "output": {"entities": {}}, "schema": []}
{"input": "Prediction of the times of sandfly development", "output": {"entities": {}}, "schema": []}
{"input": "Native human fibrinogen was brought to coagulation by adding thrombin.", "output": {"entities": {"gene": [{"text": "human fibrinogen", "start": 7, "end": 23}, {"text": "thrombin", "start": 61, "end": 69}]}}, "schema": []}
{"input": "No post-operative haemorrhages from the prostheses were observed.", "output": {"entities": {}}, "schema": []}
{"input": "The Southern technique allowed a further localization of the region of most extensive transcription to a 1. 8 kb HindIII-EcoRI fragment.", "output": {"entities": {"gene": [{"text": "HindIII", "start": 113, "end": 120}, {"text": "EcoRI", "start": 121, "end": 126}]}}, "schema": []}
{"input": "Accepting arbitrarily chosen limits of maximized errors of +/-10%, it could be shown that the system did not work acceptably when the mean carbon dioxide concentration was below 1. 5 vol.% within the fresh gas flow rates (2. 2--7. 7 1 min-1) and the range of minute ventilation (4--10 1 min-1) employed.", "output": {"entities": {}}, "schema": []}
{"input": "SV increased less in SHR, mainly reflecting the reduced diastolic compliance of the hypertrophied SHR left ventricle and the consequent rightward shift of its Frank-Starling curve.", "output": {"entities": {}}, "schema": []}
{"input": "The carcass of a great horned owl (Bubo virginianus), which had been found moribund in southern Ontario, was presented for necropsy.", "output": {"entities": {}}, "schema": []}
{"input": "The inner ears were exposed by microdissection, and the vestibular sensory regions were either sectioned and studied with light or electron microscopy, or prepared and studied with the surface specimen technique.", "output": {"entities": {}}, "schema": []}
{"input": "Patulin is extracted from apple butter samples with ethyl acetate and the extract is cleaned up on a silica gel column, using benzene-ethyl acetate (75 + 25) as the eluant.", "output": {"entities": {}}, "schema": []}
{"input": "Steroid glucuronides in amniotic fluid at term.", "output": {"entities": {}}, "schema": []}
{"input": "The matrix surrounding the clusters either showed a normal morphology or a homogeneous appearance, within which faint cross striations but no distinctly fibrillar outlines could be identified.", "output": {"entities": {}}, "schema": []}
{"input": "Riboflavin did not affect the percentage of aflatoxin-treated animals with abnormal urinary excretion patterns, but did increase the magnitude of the disturbances in elimination of kynurenic and xanthurenic acids.", "output": {"entities": {}}, "schema": []}
{"input": "Polyglactin 910 suture absorption and the role of cellular enzymes.", "output": {"entities": {}}, "schema": []}
{"input": "The incidence of DNCB reactions was 78 per cent for Stage I and II cancers (37 patinets), 73 per cent for resectable Stage III cancer (22 patients), and 66 per cent in patients with unresectable or inoperable Stage III cancer.", "output": {"entities": {}}, "schema": []}
{"input": "Studies of lipoproteins should, however, be made in children from families known to have FH or early coronary heart disease.", "output": {"entities": {}}, "schema": []}
{"input": "Sixteen other normal subjects with 2 g of Metyrapone are best responses.", "output": {"entities": {}}, "schema": []}
{"input": "EEG theta waves and psychological phenomena: a review and analysis.", "output": {"entities": {}}, "schema": []}
{"input": "REM dream content was scored for categories suggesting the predominant influence of the left hemisphere, e. g., good ego functioning, verbalization, or the right hemisphere, e. g., music, spatial salience, bizarreness.", "output": {"entities": {}}, "schema": []}
{"input": "Innervation of the ventral diaphragm of the locust (Locusta migratoria).", "output": {"entities": {}}, "schema": []}
{"input": "Ectopic ACTH syndrome and medullary thyroid carcinoma.", "output": {"entities": {"gene": [{"text": "ACTH", "start": 8, "end": 12}]}}, "schema": []}
{"input": "A striking finding in all of the studies was a positive correlation between PI ACTH and MSH contents.", "output": {"entities": {"gene": [{"text": "ACTH", "start": 79, "end": 83}, {"text": "MSH", "start": 88, "end": 91}]}}, "schema": []}
{"input": "Chronic hypophosphatemia is the most common type of \" resistant \" rickets.", "output": {"entities": {}}, "schema": []}
{"input": "There was no correlation between serum LH and chronological or bone age in this age group, which suggests that the correlation found is not due to age-related parallel phenomena.", "output": {"entities": {"gene": [{"text": "serum LH", "start": 33, "end": 41}]}}, "schema": []}
{"input": "Molecular neurochemistry of addictive drugs.", "output": {"entities": {}}, "schema": []}
{"input": "Efforts were made to determine the amount of time required for kidney lesions to develop and, if possible, to delineate the potential site of action of PBB.", "output": {"entities": {}}, "schema": []}
{"input": "Effect of succimer on the intensity of tricarboxylic acid dehydrogenase reactions in the brain of rats poisoned with mercuric chloride", "output": {"entities": {"gene": [{"text": "tricarboxylic acid dehydrogenase", "start": 39, "end": 71}]}}, "schema": []}
{"input": "Distribution and correlations of serum uric-acid in two French adult populations: 13, 885 men and 6, 861 women", "output": {"entities": {}}, "schema": []}
{"input": "The incidence of hepatitis B antigen following transfusion was about 2. 8 per cent.", "output": {"entities": {"gene": [{"text": "hepatitis B antigen", "start": 17, "end": 36}]}}, "schema": []}
{"input": "Technetium-99m stannous pyrophosphate myocardial scintigrams were obtained in 138 clinically stable patients 32. 7 +/-47. 3 weeks (range 6 to 260) after acute myocardial infarction.", "output": {"entities": {}}, "schema": []}
{"input": "A similar phenomenon has been reported in a few humans.", "output": {"entities": {}}, "schema": []}
{"input": "The decline in the activity of cytochrome oxidase, peroxidase and in the lipid content of peripheral neutrophils was followed by a decrease in the phagocytic activity.", "output": {"entities": {"gene": [{"text": "cytochrome oxidase", "start": 31, "end": 49}, {"text": "peroxidase", "start": 51, "end": 61}]}}, "schema": []}
{"input": "Treatment of 2 patients with pseudohypoparathyroidism type I with vitamin-D-3 and 1 alpha-Hydroxycholecalciferol consecutively resulted in a nonuniform response with regard to the normalisation of serum-calcium.", "output": {"entities": {}}, "schema": []}
{"input": "Workers with \" sensitivity \" to toluene diisocyanate (TDI) studied in depth in an attempt to determine mechanisms of bronchial hyperreactivity.", "output": {"entities": {}}, "schema": []}
{"input": "Total VO2 was decreased in both groups during severe hypoxia but limb VO2 was maintained in the beta-block group. beta-Block prevented the fall in total and limb peripheral resistance seen in severe hypoxia but did not alter the consistently more efficient utilization of total O2 delivery shown by the limb in comparison to the whole body by higher O2 extraction ratios and lower venous O2 pressure. beta-Vasodilator receptors evidently played an active part in the vasodilatation seen during severe hypoxia.", "output": {"entities": {"gene": [{"text": "beta-Vasodilator receptors", "start": 401, "end": 427}]}}, "schema": []}
{"input": "Phenobarbital-induced alterations in the metabolism of [3H] vitamin D3 by the perfused rachitic rat liver in vitro.", "output": {"entities": {}}, "schema": []}
{"input": "Modulation of 25-hydroxyvitamin D3-24-hydroxylase by aminophylline: a cytochrome P-450 monooxygenase system.", "output": {"entities": {"gene": [{"text": "25-hydroxyvitamin D3-24-hydroxylase", "start": 14, "end": 49}, {"text": "cytochrome P-450 monooxygenase", "start": 70, "end": 100}]}}, "schema": []}
{"input": "In both these respects, however, the DBP mRNA resembles the late messengers of SV40 and polyoma viruses.", "output": {"entities": {"gene": [{"text": "DBP mRNA", "start": 37, "end": 45}]}}, "schema": []}
{"input": "Effect of corticosteroid-containing antirheumatic combination drugs on endogenous ACTH and cortisol production.", "output": {"entities": {"gene": [{"text": "ACTH", "start": 82, "end": 86}]}}, "schema": []}
{"input": "Serum ACTH did not respond to insulin and metyrapone.", "output": {"entities": {"gene": [{"text": "Serum ACTH", "start": 0, "end": 10}, {"text": "insulin", "start": 30, "end": 37}]}}, "schema": []}
{"input": "Anatomy of the RNA and gene products of MC29 and MH2, two defective avian tumor viruses causing acute leukemia and carcinoma: evidence for a new class of transforming genes.", "output": {"entities": {}}, "schema": []}
{"input": "Bertioga (Guama group) and Anhembi (Bunyamwera group), two new arboviruses isolated in Sao Paulo, Brazil.", "output": {"entities": {}}, "schema": []}
{"input": "Gamma glutamyl transpeptidase activity was increased up to 15 times above the upper normal limit in children, who received aminopyrine for two weeks or longer.", "output": {"entities": {"gene": [{"text": "Gamma glutamyl transpeptidase", "start": 0, "end": 29}]}}, "schema": []}
{"input": "XXI.", "output": {"entities": {}}, "schema": []}
{"input": "A gas-liquid chromatographic method for the determination of p-chlorophenoxyisobutyric (CPIB) acid in blood plasma is described.", "output": {"entities": {}}, "schema": []}
{"input": "Dopamine receptor blockade and the neuroleptics, a crystallographic study.", "output": {"entities": {"gene": [{"text": "Dopamine receptor", "start": 0, "end": 17}]}}, "schema": []}
{"input": "V.", "output": {"entities": {}}, "schema": []}
{"input": "A rapid fluorimetric procedure for the determination of the fungicide 5-fluorocytosine in serum is described.", "output": {"entities": {}}, "schema": []}
{"input": "The' field of stress' of the supervisory nurse", "output": {"entities": {}}, "schema": []}
{"input": "How do graduates of different types of programs perform on state boards?", "output": {"entities": {}}, "schema": []}
{"input": "Similarly, maternal serum somatomedin A was significantly reduced in rats nursing large litters.", "output": {"entities": {"gene": [{"text": "maternal serum somatomedin A", "start": 11, "end": 39}]}}, "schema": []}
{"input": "The sequences following the X. borealis oocyte and somatic 5S genes are identical in 12 of the first 14 residues and contain two or more T clusters, as does the corresponding region of X. laevis oocyte 5S DNA.", "output": {"entities": {"gene": [{"text": "5S genes", "start": 59, "end": 67}, {"text": "X. laevis oocyte 5S DNA", "start": 185, "end": 208}]}}, "schema": []}
{"input": "This mechanism is not due to the observed grain boundary precipitates.", "output": {"entities": {}}, "schema": []}
{"input": "This report has reviewed some of the reasons for treatment failures and has presented a philosophy for their management.", "output": {"entities": {}}, "schema": []}
{"input": "Diagnosis and treatment planning in Class II, division 2", "output": {"entities": {}}, "schema": []}
{"input": "Because of serious infections (fever larger than or equal to 101 degrees F. granulocytes less than 1, 000/mm, 3 and hospitalization) and 1 drug death in the first 4 patients, oral calcium leucovorin, 20 to 30 mg/m2 orally, was given 2 days after methotrexate in subsequent treatment cycles.", "output": {"entities": {}}, "schema": []}
{"input": "It seems that the way in which drugs modify a patient' s serum chemistry may be used to assess the efficacy with which they control the inflammatory process.", "output": {"entities": {}}, "schema": []}
{"input": "Here the conventional tests clearly pointed to the presence of retrocochlear disease.", "output": {"entities": {}}, "schema": []}
{"input": "The end-stage or involutional phase of proliferative diabetic retinopathy may result in stabilization of vision for long periods of time.", "output": {"entities": {}}, "schema": []}
{"input": "On the basis of serum alpha1AT quantitation, newborn infants may be separated into two groups, characterized respectively by concentrations above or below 150 mg%.", "output": {"entities": {"gene": [{"text": "serum alpha1AT", "start": 16, "end": 30}]}}, "schema": []}
{"input": "In patients who were not vented, there was overall significant depression of function (67 +/-5% of control; range, 91--45%, p less than 0. 01).", "output": {"entities": {}}, "schema": []}
{"input": "Changes in body weight and agonistic behavior were also recorded.", "output": {"entities": {}}, "schema": []}
{"input": "The uterine response to prostaglandin E2 (PGE2) and prostaglandin F2alpha (administered by intravenous and intrauterine routes) was evaluated during different phases of the menstrual cycle in five functionally infertile women.", "output": {"entities": {}}, "schema": []}
{"input": "A total of 26 BCG strains, out of them 10 Czechoslovak strains (2 lyophilized cultures of BCG of different batch, 6 strains isolated from abscesses of children after BCG-vaccination and 2 strains from fatal cases after BCG-vaccination) and 16 strains obtained from foreign laboratories, were used.", "output": {"entities": {}}, "schema": []}
{"input": "High levels of serum calcitonin were found in patients with chronic renal failure.", "output": {"entities": {"gene": [{"text": "calcitonin", "start": 21, "end": 31}]}}, "schema": []}
{"input": "Detection of anti-lymphocyte antibodies using the immunoperoxidase antiglobulin technic.", "output": {"entities": {"gene": [{"text": "immunoperoxidase antiglobulin", "start": 50, "end": 79}]}}, "schema": []}
{"input": "The response of serum GH to arginine infusion was normal, while that to insulin-induced hypoglycemia was poor.", "output": {"entities": {"gene": [{"text": "serum GH", "start": 16, "end": 24}, {"text": "insulin", "start": 72, "end": 79}]}}, "schema": []}
{"input": "The mortality rate and histopathological features of Nocardia asteroides and Nocardia brasiliensis infections in congenitally athymic (nude) mice of ICR and C3H/eB origins were quite different from what we found for Swiss white mice and other inbred mouse strains (namely, C57/BL/6J, New Zealand Black, BALB/c, CBA/LAC, and C3H/eB).", "output": {"entities": {}}, "schema": []}
{"input": "Williams, 2 August 1977.", "output": {"entities": {}}, "schema": []}
{"input": "Use of radioactive isotopes in the chemistry of proteins", "output": {"entities": {}}, "schema": []}
{"input": "(Emeritus) John Henri Roosegaarde Bisschop", "output": {"entities": {}}, "schema": []}
{"input": "Disrupted vaccines and whole-virus vaccines containing type B antigen only did not cause significant reactivity.", "output": {"entities": {"gene": [{"text": "type B antigen", "start": 55, "end": 69}]}}, "schema": []}
{"input": "255-61.", "output": {"entities": {}}, "schema": []}
{"input": "Antenatal diagnosis of haematological disorders--' 1978'.", "output": {"entities": {}}, "schema": []}
{"input": "Hepatic oxygen supply and selected blood parameters were recorded in fasted male rates given 20--30 mg/kg Escherichia coli endotoxin intraperitoneally.", "output": {"entities": {"gene": [{"text": "Escherichia coli endotoxin", "start": 106, "end": 132}]}}, "schema": []}
{"input": "Gonadal dysfunction in patients with ataxia telangiectasia.", "output": {"entities": {}}, "schema": []}
{"input": "The maximum period of treatment was 73 (oral), 73 (intraperitoneal) or 75 (dermal) weeks.", "output": {"entities": {}}, "schema": []}
{"input": "A study of the comparative efficacy of diflucortolone valerate 0. 3% ointment and clobetasol propionate 0. 05% ointment.", "output": {"entities": {}}, "schema": []}
{"input": "Most of the phenomena of azotaemic osteodystrophy are encountered in simple vitamin D deficiency; as in that condition, deficiency of 1, 25-dihydroxycholecalciferol may be of primary significance in causing secondary hyperparathyroidism in renal failure.", "output": {"entities": {}}, "schema": []}
{"input": "Basal FSH and LH levels were significantly lower in addicts; after GnRH stimulation the addicts' FSH and LH values increased but not significantly compared to controls.", "output": {"entities": {"gene": [{"text": "FSH", "start": 6, "end": 9}, {"text": "LH", "start": 14, "end": 16}, {"text": "GnRH", "start": 67, "end": 71}, {"text": "FSH", "start": 97, "end": 100}, {"text": "LH", "start": 105, "end": 107}]}}, "schema": []}
{"input": "Adriamycin: comparison of a 5-week schedule with a 3-week schedule in the treatment of breast cancer.", "output": {"entities": {}}, "schema": []}
{"input": "Follow-up controls of luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (HPRL), oestradiol (E2), progesterone (P) and testosterone (T) in the catabolic and healing phase of burn disease.", "output": {"entities": {"gene": [{"text": "luteinizing hormone", "start": 22, "end": 41}, {"text": "LH", "start": 43, "end": 45}, {"text": "follicle stimulating hormone", "start": 48, "end": 76}, {"text": "FSH", "start": 78, "end": 81}, {"text": "prolactin", "start": 84, "end": 93}, {"text": "HPRL", "start": 95, "end": 99}]}}, "schema": []}
{"input": "Renin studies performed in 34 hypertensive patients and in a control group of 11 recipients showed that elevation of plasma renin activity and of plasma aldosterone level is frequent but difficult to interpret, particularly when a renal artery stenosis is observed.", "output": {"entities": {"gene": [{"text": "Renin", "start": 0, "end": 5}, {"text": "plasma renin", "start": 117, "end": 129}]}}, "schema": []}
{"input": "A randomized clinical trial in sixty-two adult patients suffering from typhoid fever, proved by blood and marrow culture, showed that amoxycillin in a dosage schedule of 1 g 8-hourly orally for fourteen days was better than chloramphenicol with regard to clinical and temperature response and in respect of carriers and relapse rates.", "output": {"entities": {}}, "schema": []}
{"input": "202-8.", "output": {"entities": {}}, "schema": []}
{"input": "Bone marrow transplantation-1979.", "output": {"entities": {}}, "schema": []}
{"input": "In this article, the clinical actions of the principal dopamine receptor stimulating agents (apomorphine and its derivatives; piribedil, rye-ergot derivatives) are discussed on the basis of their biochemical and pharmacological properties.", "output": {"entities": {"gene": [{"text": "dopamine receptor", "start": 55, "end": 72}]}}, "schema": []}
{"input": "The unilateral vestibular hypofunction.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, the inhibition of pepsin in human gastric juice does not appear to have a major influence on the healing of duodenal ulcer.", "output": {"entities": {"gene": [{"text": "pepsin", "start": 24, "end": 30}]}}, "schema": []}
{"input": "The IDF standard method for the detection of penicillin in milk is not suitable for the detection of sulphonamide residues in milk.", "output": {"entities": {}}, "schema": []}
{"input": "Capsular antigens of Staphylococcus aureus", "output": {"entities": {}}, "schema": []}
{"input": "The course of endotoxin fever remained uninfluenced by ALS.", "output": {"entities": {}}, "schema": []}
{"input": "2 new Algerian cases", "output": {"entities": {}}, "schema": []}
{"input": "Seventy-one percent of patients treated with ticarcillin alone responded favorably.", "output": {"entities": {}}, "schema": []}
{"input": "Accurate pathologic staging identifies patients who are potentially curable with radiotherapy.", "output": {"entities": {}}, "schema": []}
{"input": "Inherent hematology of old age", "output": {"entities": {}}, "schema": []}
{"input": "Neomycin is fairly effective against staphylococci, less effective against streptococci, and fairly effective against gram-negative intestinal organisms.", "output": {"entities": {}}, "schema": []}
{"input": "It was concluded, that on a given section, 75, 7 per cent of the trabeculae were in contact with vascular cavities.", "output": {"entities": {}}, "schema": []}
{"input": "2.", "output": {"entities": {}}, "schema": []}
{"input": "Changes in tissue PCO2 were less dramatic and did not vary significantly from those recorded in venous blood.", "output": {"entities": {}}, "schema": []}
{"input": "Ultrasonic evaluation of renal calculi.", "output": {"entities": {}}, "schema": []}
{"input": "Recognition of emphysema was poor when radiographs of inadequate quality were included (anteroposterior films or films from patients with acute or chronic lung disease).", "output": {"entities": {}}, "schema": []}
{"input": "Isolation of T. gambiense strains in Zaire and their adaptation to laboratory animals", "output": {"entities": {}}, "schema": []}
{"input": "Pharmacokinetic profile of clonazepam in rhesus monkeys.", "output": {"entities": {}}, "schema": []}
{"input": "Immunologic mechanisms in chronic brucellosis in humans.", "output": {"entities": {}}, "schema": []}
{"input": "Intestinal adaptation (first of two parts).", "output": {"entities": {}}, "schema": []}
{"input": "In patients who had received no previous drug treatment, log baseline plasma renin activity and change in mean blood pressure after SQ 20881 correlated significantly (r = 0. 651, P less than 0. 05).", "output": {"entities": {"gene": [{"text": "plasma renin", "start": 70, "end": 82}]}}, "schema": []}
{"input": "These techniques have been used by many people for many years and no claim is being made for any innovation in this regard.", "output": {"entities": {}}, "schema": []}
{"input": "40 patients with chronic osteomyelitis were treated per os with the bactericidal beta-lactam-antibiotic cephalexin during 3 to 60 weeks.", "output": {"entities": {}}, "schema": []}
{"input": "A total of 57 patients with Hodgkin' s disease limited to above the diaphragm (Stages I and II, A and B) were treated with radiation therapy alone at the University of Florida between 1964 and 1974.", "output": {"entities": {}}, "schema": []}
{"input": "Year one of the first general practitioner medical unit in the greater Glasgow area.", "output": {"entities": {}}, "schema": []}
{"input": "This multiple-electrode array for round window cochlear implantation is a robust, reliable system for inserting 20 mm along the scala tympani with a minimum of trauma and can provide for bipolar stimulation.", "output": {"entities": {}}, "schema": []}
{"input": "As authorized by the World Health Organization 29th Expert Committee on Biological Standardization, the preparation of human prolactin in ampoules coded 75/504 has been established as the International Reference Preparation (IRP) of human prolactin for immunoassay.", "output": {"entities": {"gene": [{"text": "human prolactin", "start": 119, "end": 134}, {"text": "human prolactin", "start": 233, "end": 248}]}}, "schema": []}
{"input": "i.", "output": {"entities": {}}, "schema": []}
{"input": "Biliary-enteric fistulas", "output": {"entities": {}}, "schema": []}
{"input": "Plasma ion changes in venous blood incubated with beta receptor blockers and subjected to tonometry in vitro.", "output": {"entities": {"gene": [{"text": "beta receptor", "start": 50, "end": 63}]}}, "schema": []}
{"input": "Such marked differences are found occasionally in the literature: heterophile antibodies against bovine gammaglobulin are regarded as responsible for the interference in the Sephadex system of RIST.", "output": {"entities": {"gene": [{"text": "bovine gammaglobulin", "start": 97, "end": 117}]}}, "schema": []}
{"input": "\" Let the hundred flowers bloom \".", "output": {"entities": {}}, "schema": []}
{"input": "Various treatment modalities are reviewed in the context of the psychology as well as the physiology of severe intractable pain.", "output": {"entities": {}}, "schema": []}
{"input": "Lethal Tachmalcor (4-(3'-diethylamino-2'-hydroxypropyl)-ajmaline) poisoning in childhood", "output": {"entities": {}}, "schema": []}
{"input": "Ophthalmosonographic evaluation of blood flow velocity in arteriocavernous fistula", "output": {"entities": {}}, "schema": []}
{"input": "Serum ferritin concentration and bone marrow iron stores.", "output": {"entities": {"gene": [{"text": "ferritin", "start": 6, "end": 14}]}}, "schema": []}
{"input": "The systolic pressure gradient (SPG) between the left ventricle (LV) and left atrium (LA) was obtained from high-fidelity pressure transducers.", "output": {"entities": {}}, "schema": []}
{"input": "A prospective trail comparing hysterectomy, hysterectomy plus vaginal radium, and uterine radium plus hysterectomy in stage I endometrial carcinoma.", "output": {"entities": {}}, "schema": []}
{"input": "On the basis of a patient' s report of one inaccurate Clinitemp, we undertook to investigate the accuracy of this thermometer.", "output": {"entities": {}}, "schema": []}
{"input": "Cryoglobulinemia in Raynaud' s syndrome", "output": {"entities": {}}, "schema": []}
{"input": "Data were processed with a semi-automatic computer program which develops an averaged-volume curve from an assigned LV region-of-interest.", "output": {"entities": {}}, "schema": []}
{"input": "The preferential serum IgA response observed in the patient population suggests that bronchial associated lymphoid tissue in the diseased lung is an important source of circulating IgA.", "output": {"entities": {"gene": [{"text": "serum IgA", "start": 17, "end": 26}, {"text": "IgA", "start": 181, "end": 184}]}}, "schema": []}
{"input": "Ultimate strengthes seem to be reached for cast cobalt alloys, whereas titanium alloys, such as Ta 6 V, present very high fatigue limit under corrosion.", "output": {"entities": {}}, "schema": []}
{"input": "The effects of intracisternal injection (i. c. i.) of clonidine (1 microgram kg-1) on blood pressure and heart rate were studied in conscious rabbits with an implanted catheter in the cisterna magna.", "output": {"entities": {}}, "schema": []}
{"input": "Platelet number and life span were determined in the last trimester of pregnancy in 22 women who were delivered of small-for-gestational age (SGA) infants and in 21 women with infants having normal birth weights.", "output": {"entities": {}}, "schema": []}
{"input": "Serial measurements of total serum IgE appears to be a useful index of disease activity in ABPA.", "output": {"entities": {"gene": [{"text": "IgE", "start": 35, "end": 38}]}}, "schema": []}
{"input": "A rise of hemoglobin concentration accompanied by an increase of the total iron in the blood serum of white mice was found under oxygen pressure of 4 atm for an hour (preconvulsive state) and 6 atm (convulsive state).", "output": {"entities": {"gene": [{"text": "hemoglobin", "start": 10, "end": 20}]}}, "schema": []}
{"input": "Nernst--Planck analog equations and stationary state membrane electric potentials.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of methylene chloride, trichloroethane, trichloroethylene, tetrachloroethylene and toluene on the development of chick embryos.", "output": {"entities": {}}, "schema": []}
{"input": "Effect of intraventricular administration of streptolysin O on the electroencephalogram of rabbits.", "output": {"entities": {"gene": [{"text": "streptolysin O", "start": 45, "end": 59}]}}, "schema": []}
{"input": "In this situation the convlusion threshold for the 8 substances is as follows: pethidine 20 mg. kg-1 I. V., piritramide 30, morphine 180, phenoperidine 4, R 39 209 5, fentanyl 4, sufentanil 4 and R 34 995 10 mg. kg-1 I. V.", "output": {"entities": {}}, "schema": []}
{"input": "Roentgenographically, the lesion was usually a well-defined and benign appearing one, either purely lytic (3 cases) or with central radiodensity (2 cases).", "output": {"entities": {}}, "schema": []}
{"input": "Effects of chronic descending tractotomy on the response patterns of neurons in the trigeminal nuclei principalis and oralis.", "output": {"entities": {}}, "schema": []}
{"input": "Efficacy of a three-versus a five-week alcohol treatment program.", "output": {"entities": {}}, "schema": []}
{"input": "Isolated calcaneal tuberculous osteomyelitis.", "output": {"entities": {}}, "schema": []}
{"input": "It is concluded that opiate receptors bordering the fourth cerebral ventricle mediate the cardiovascular and hypnotic action of fentanyl.", "output": {"entities": {"gene": [{"text": "opiate receptors", "start": 21, "end": 37}]}}, "schema": []}
{"input": "In case of a pathologically convoluted internal carotid the common carotid artery was resected with an end-to-end anastomosis.", "output": {"entities": {}}, "schema": []}
{"input": "These data confirm the existence of hyperlipemic abdominal crisis as a distinct entity and testify to the importance of recognizing this syndrome in order to avoid the occurrence of acute pancreatitis and the performance of unnecessary and potentially harmful surgery.", "output": {"entities": {}}, "schema": []}
{"input": "In addition a significant Treatment X Strain interaction was due to the larger defecation numbers displayed by the taurine-injected MR rats relative to the saline-injected MR rats.", "output": {"entities": {}}, "schema": []}
{"input": "The failures frequently were related to patient intolerance or poor mechanical fit and occurred in the first few days or first few months after insertion.", "output": {"entities": {}}, "schema": []}
{"input": "These characteristics indicated the pronounced activity of collagenous fiber synthesis and the matrix of the osteoid tissue.", "output": {"entities": {}}, "schema": []}
{"input": "Carbohydrate metabolism and the semen profile: glucose, insulin, and sperm studies.", "output": {"entities": {"gene": [{"text": "insulin", "start": 56, "end": 63}]}}, "schema": []}
{"input": "It has come out that CAEC is between CC and CIEC and that attacks of biliary fever and high levels of alkaline phosphatase and transaminases in the serum are the helpful findings for preoperative diagnosis.", "output": {"entities": {"gene": [{"text": "alkaline phosphatase", "start": 102, "end": 122}]}}, "schema": []}
{"input": "The sub-acute inhalation toxicity of furfural was studied in Syrian golden hamsters.", "output": {"entities": {}}, "schema": []}
{"input": "A study of the E. O. R. T. C.", "output": {"entities": {}}, "schema": []}
{"input": "An intravenous preparation of doxycycline (DOTC, Vibramycin' Pfizer'), a long-lasting tetracycline, was administered mainly by drip infusion for a series of study in the pediatrics field, and the results were as follows: 1) DOTC (100 mg) was dissolved in a 100 ml of glucose solution and 2--3 mg/kg was administered intravenously.", "output": {"entities": {}}, "schema": []}
{"input": "5) Before and ten days after DOTC infusion, laboratory tests for liver and renal functions and blood were performed.", "output": {"entities": {}}, "schema": []}
{"input": "Structural characteristics of the erythrocyte membrane, peroxidation processes and antioxidant function in children with diffuse glomerulonephritis", "output": {"entities": {}}, "schema": []}
{"input": "The enteric route is the principal mode of transmission for hepatitis A, but maximal levels of hepatitis A virus excretion occur before the onset of jaundice.", "output": {"entities": {}}, "schema": []}
{"input": "All 13 patients showed endoscopic evidence of oesophagitis, moderate in 4 and severe in 9.", "output": {"entities": {}}, "schema": []}
{"input": "Urinary excretion of oestrone, oestradiol-17 beta and oestriol in pregnancies complicated by steroid sulphatase deficiency.", "output": {"entities": {"gene": [{"text": "steroid sulphatase", "start": 93, "end": 111}]}}, "schema": []}
{"input": "Both reduced spontaneous locomotor activity in mice, protected them from death from amphetamine induced toxicity, prolonged hexobarbitone sleeping time and caused a depletion of catecholamines from various organs of the rat.", "output": {"entities": {}}, "schema": []}
{"input": "On the role of transferrin in the uptake of gallium by tumor cells.", "output": {"entities": {"gene": [{"text": "transferrin", "start": 15, "end": 26}]}}, "schema": []}
{"input": "Irradiation of human blood platelets with UV-A in vitro impairs their ability to aggregate after challenge with collagen.", "output": {"entities": {"gene": [{"text": "collagen", "start": 112, "end": 120}]}}, "schema": []}
{"input": "Following the satisfactory results and taking into account that the complications had reduced to a very low rate (in 2 cases lead tip displacement and pouch haematoma occurred respectively), the Authors consider the adopted method an useful approach for PMK implantation particularly when the use of the vena cephalica is deemed impossible.", "output": {"entities": {}}, "schema": []}
{"input": "When two determinations were performed on 12 samples of plasma taken from normal adults in October, the values were 22. 6 +/-4. 8 and 21. 0 +/-3. 6 (mean +/-SD) ng/ml, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "The six commonest causes of death varied in the three ethnic groups.", "output": {"entities": {}}, "schema": []}
{"input": "Although Grice' s operation has been used all over the world, no systematic account of it has been found in the literature (including publications dealing with technique), which presents it in terms related to the basic \" classical \" principles on which the operation was conceived.", "output": {"entities": {}}, "schema": []}
{"input": "(5) No changes were observed in the gastric venous blood flow by continuous intravenous injection of cimetidine, but by rapid injection both the flow was augmented and the systemic blood pressure decreased transiently.", "output": {"entities": {}}, "schema": []}
{"input": "Study on re-establishment of ovulation after termination of sex-steroidal treatment--compared with re-appearance of ovulation after abortion and premature delivery.", "output": {"entities": {}}, "schema": []}
{"input": "Pharmacokinetics of Carbamazepine in man: a review.", "output": {"entities": {}}, "schema": []}
{"input": "Of the compounds tested, alpha-(3-methyl-2-quinoxalinyl)-N-methylnitrone 1, 4-dioxide (2) was the most active agent in vivo against the gram-negative and the gram-positive organisms.", "output": {"entities": {}}, "schema": []}
{"input": "Changes in ionic content of the mucous suggest that cholinergic mechanisms affect pressure in the excretory duct of the gland.", "output": {"entities": {}}, "schema": []}
{"input": "Calves fed MCT-milk had significantly lower blood cholesterol than calves fed T-or SBO-milk.", "output": {"entities": {}}, "schema": []}
{"input": "Under halothane anesthesia, the flow pneumocardiogram (PnCG) and its time derivative (acceleration pneumocardiogram or dPn/dt) were transduced during apnea by a small high-gain pneumotachograph.", "output": {"entities": {}}, "schema": []}
{"input": "Sensory kindling: implications for development of sensory prostheses.", "output": {"entities": {}}, "schema": []}
{"input": "It is concluded that stereotypy can be evoked also in the case when the striatal dopaminergic tone is normal or even below normal: it is the equilibrium of the striatal cholinergic-dopaminergic systems which must be shifted towards dopamine, which is necessary for the development of this behavioral manifestation.", "output": {"entities": {}}, "schema": []}
{"input": "In the duodenum a small part of the administered dose was transformed to 3H-alpha-acetyldigoxin.", "output": {"entities": {}}, "schema": []}
{"input": "Functional effects following subacute administration.", "output": {"entities": {}}, "schema": []}
{"input": "Although it has been shown that it is possible to use orally administered testosterone to maintain se-T levels in the normal male range, the convenience to the patient must be balanced against the cost and possible side effects of the large doses required.", "output": {"entities": {}}, "schema": []}
{"input": "Contrary to 1, 8-dihydroxy-9-anthrone, 1, 8, 9-triacetoxyanthracene and 1, 8-diacetoxy-9-anthrone are effective against psoriatic lesions without accompanying inflammations of the skin.", "output": {"entities": {}}, "schema": []}
{"input": "Etiopathogenetic and therapeutic problems in acute orbital inflammation", "output": {"entities": {}}, "schema": []}
{"input": "Nursing of patients with gynecological diseases", "output": {"entities": {}}, "schema": []}
{"input": "We measured basal plasma prolactin concentrations (in samples obtained during the early follicular phase) in 25 normal (control) women and in a similar group of 40 patients with a long-standing history of infertility.", "output": {"entities": {"gene": [{"text": "prolactin", "start": 25, "end": 34}]}}, "schema": []}
{"input": "Ovarian allotransplantation in human.", "output": {"entities": {}}, "schema": []}
{"input": "Screening of asthma patients by determination of IgE and by comprehension of spectrum of allergospecific IgE antibodies", "output": {"entities": {"gene": [{"text": "IgE", "start": 49, "end": 52}]}}, "schema": []}
{"input": "The induction of seizures in \" Papio papio \" following allylglycine alone or in combination with intermittent photic stimulation", "output": {"entities": {}}, "schema": []}
{"input": "A highly significant correlation was found between the presence of fibrinolytic degradation products (FDP) and the incidence of nephropathy and renal insufficiency, as well as between the presence of fibrin monomers (Godal' s ethanol-gelification test) and the evolutive signs of the primary disease (fever, accelerated ESR).", "output": {"entities": {"gene": [{"text": "fibrin monomers", "start": 200, "end": 215}]}}, "schema": []}
{"input": "In girls prolactin levels rise at stage 2, and are higher after menarche; in boys there is no change in prolactin levels.", "output": {"entities": {"gene": [{"text": "prolactin", "start": 9, "end": 18}, {"text": "prolactin", "start": 104, "end": 113}]}}, "schema": []}
{"input": "2 cases of toxic lymphomononucleosis", "output": {"entities": {}}, "schema": []}
{"input": "Such an hemoglobin solution was shown to exhibit a high affinity for oxygen and a low Bohr effect (assessed from the delta log Po2/delta pH ratio).", "output": {"entities": {"gene": [{"text": "hemoglobin", "start": 8, "end": 18}]}}, "schema": []}
{"input": "A one-week ulcer therapy with atropine and Vikalin (Roter) led to a significant (p less than 0. 01) reduction of the nocturnal proteolytic activity.", "output": {"entities": {}}, "schema": []}
{"input": "In one patient with severe diarrhea the estriol concentration in serum was low until the intestinal function normalised and the estriol concentration went up exactly when the diarrhea stopped.", "output": {"entities": {}}, "schema": []}
{"input": "Serum levels of IgG and IgM were also raised, but contrary to the findings of other observers IgA levels were normal.", "output": {"entities": {"gene": [{"text": "IgG", "start": 16, "end": 19}, {"text": "IgM", "start": 24, "end": 27}, {"text": "IgA", "start": 94, "end": 97}]}}, "schema": []}
{"input": "Experimental ischemic heart disease induced by thromboxane A2 in rabbits.", "output": {"entities": {}}, "schema": []}
{"input": "Vitrectomy in ocular traumatology", "output": {"entities": {}}, "schema": []}
{"input": "To study the sensitivity of some central brain structures to the action of an electromagnetic field of decimeter waves (EMF of DW) a dynamic investigation of single unit activity was undertaken.", "output": {"entities": {}}, "schema": []}
{"input": "No systematic L-R differences were observed.", "output": {"entities": {}}, "schema": []}
{"input": "A decrease of the lysozyme activity coincided with the clinical improvement of the bacterial meningitis.", "output": {"entities": {"gene": [{"text": "lysozyme", "start": 18, "end": 26}]}}, "schema": []}
{"input": "1 The effects in normal subjects of a single oral dose of Motival (one tablet, containing fluphenazine 0. 5 mg and nortriptyline 10 mg) on the contingent negative variation (CNV), reaction time, heart rate, blood pressure and self-rating scales for alertness, anxiety, tension, detachment and depression were compared with those of diazepam (5 mg and 7. 5 mg) and placebo or propranolol (60 mg).", "output": {"entities": {}}, "schema": []}
{"input": "Stress effects on affiliation preferences among subjects possessing the type A coronary-prone behavior pattern.", "output": {"entities": {}}, "schema": []}
{"input": "These show that the collagen in this tissue is modified compared with that in tendon.", "output": {"entities": {"gene": [{"text": "collagen", "start": 20, "end": 28}]}}, "schema": []}
{"input": "Smoking was regarded as the major contribution to pulmonary dysfunction.", "output": {"entities": {}}, "schema": []}
{"input": "The malignity of nevoid lentigo.", "output": {"entities": {}}, "schema": []}
{"input": "These responses were compared with others in the same subjects under the same conditions and it was concluded that the antihypertensive effect of labetalol is explained by concurrent blockade of alpha-and beta-adrenoceptors.", "output": {"entities": {"gene": [{"text": "alpha-and beta-adrenoceptors", "start": 195, "end": 223}]}}, "schema": []}
{"input": "Diuretics: basic clinical pharmacology and therapeutic use.", "output": {"entities": {}}, "schema": []}
{"input": "Three patients with four renoureteral units have undergone single-stage reconstruction involving ureteroureterostomy and ipsilateral ureteroneocystostomy following temporary loop cutaneous ureterostomy.", "output": {"entities": {}}, "schema": []}
{"input": "Internally oriented patients' scores on Rotter' s Internal-External Locus of Control Scale remained the same over treatment but those of externally oriented patients shifted toward greater internal control.", "output": {"entities": {}}, "schema": []}
{"input": "Action of strontium-90 and metaphos on Cyprinus carpio", "output": {"entities": {}}, "schema": []}
{"input": "Kodak XV-2 film is wrapped around a cylindrical water-filled phantom and the dose distribution is recorded.", "output": {"entities": {}}, "schema": []}
{"input": "Diagnosis and differential diagnosis", "output": {"entities": {}}, "schema": []}
{"input": "The multiple factors affecting plasma renin activity in essential hypertension.", "output": {"entities": {"gene": [{"text": "renin", "start": 38, "end": 43}]}}, "schema": []}
{"input": "Cortisone induced bone changes and its response to lipid clearing agents.", "output": {"entities": {}}, "schema": []}
{"input": "When blood samples of patients with hyperbilirubinemia were analyzed, direct measurement of ZPP by this fluorimeter yielded significantly higher levels than did an alternate extraction method.", "output": {"entities": {}}, "schema": []}
{"input": "Delayed hypersensitivity in man: effects of systemic anticoagulation.", "output": {"entities": {}}, "schema": []}
{"input": "Experimental studies on virus excretion and non-arthropod transmission.", "output": {"entities": {}}, "schema": []}
{"input": "Prevention of acute paraquat toxicity in rats by superoxide dismutase.", "output": {"entities": {"gene": [{"text": "superoxide dismutase", "start": 49, "end": 69}]}}, "schema": []}
{"input": "Increased urinary riboflavin excretion resulting from boric acid ingestion.", "output": {"entities": {}}, "schema": []}
{"input": "Radionuclide angiography and static whole body imaging performed with technetium-99m-labeled particulates can clearly demonstrate differential shunting in patients with patent ductus arteriosus (PDA) with Eisenmenger physiology.", "output": {"entities": {}}, "schema": []}
{"input": "Looming detectors in the human visual pathway.", "output": {"entities": {}}, "schema": []}
{"input": "Escherichia of a single sero-anzymatic type (06a6b: K13: H1) were isolated in a group affection.", "output": {"entities": {}}, "schema": []}
{"input": "The method described may prove useful in studying the physiology of the nasal cycle.", "output": {"entities": {}}, "schema": []}
{"input": "At the same time we obtained easily understandable EEG-information which has never previously been available to us.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of liver biopsy specimens from patients with hepatitis showed a large variation in the mean iron content of the liver ferritin molecules.", "output": {"entities": {"gene": [{"text": "ferritin", "start": 127, "end": 135}]}}, "schema": []}
{"input": "Angiotensin effect in the human kidney.", "output": {"entities": {"gene": [{"text": "Angiotensin", "start": 0, "end": 11}]}}, "schema": []}
{"input": "Procion yellow dye was injected intracellularly into large auditory fibers of goldfish to investigate the relationship between the response type of these fibers and their site of termination in the saccular macula.", "output": {"entities": {}}, "schema": []}
{"input": "Incidental findings in the epidermis and in the intraepidermal eccrine sweat duct units.", "output": {"entities": {}}, "schema": []}
{"input": "Silicosis mortality", "output": {"entities": {}}, "schema": []}
{"input": "These consisted of beading and strictures mainly of the intrahepatic biliary tree (IHB).", "output": {"entities": {}}, "schema": []}
{"input": "Pentane and ethane, which arise during lipid peroxidation in vivo, were measured by gas chromatography in breath samples of rats fed for 8 weeks a vitamin E-deficient diet to which had been added 0, 11, or 40 IU vitamin E acetate per kg.", "output": {"entities": {}}, "schema": []}
{"input": "The effect of pure natural porcine secretin on endocrine and exocrine pancreatic secretion was studied in the totally isolated perfused porcine pancreas.", "output": {"entities": {"gene": [{"text": "porcine secretin", "start": 27, "end": 43}]}}, "schema": []}
{"input": "Biometric analysis of intraocular lens power required to produce emmetropia: results of 450 implants.", "output": {"entities": {}}, "schema": []}
{"input": "Althoug RBF tended to increase after the therapy, there was no statistically significant change in RBF, GFR and cardiac output.", "output": {"entities": {}}, "schema": []}
{"input": "Six patients with glomerulonephritis in association with a ventriculovascular shunt were treated with three basic modes of therapy.", "output": {"entities": {}}, "schema": []}
{"input": "The mass of UO2 in the extrapulmonary bronchi and first bifurcation decreased more slowly over 0--8 d after inhalation than the corresponding mass on the trachea.", "output": {"entities": {}}, "schema": []}
{"input": "Synovial cysts of the hip joint", "output": {"entities": {}}, "schema": []}
{"input": "A sharp outbreak of influenza A occurred on the base during February that was due to an A/Texas/1/77-like virus, a variant of the A/Victoria/3/75 prototpye.", "output": {"entities": {}}, "schema": []}
{"input": "Because decreases in the disfluency rates of stutterers were observed during the presentation of all three stimulus words, the data failed to support the operant model.", "output": {"entities": {}}, "schema": []}
{"input": "Effect of time and dose on alterations following inhalation of plutonium-239 dioxide aerosol in rat.", "output": {"entities": {}}, "schema": []}
{"input": "In biopsies CK-MB fraction of total myocardial CPK was 37%, the total-CPK activity of human skeletal muscles still shows a 5% fraction of CK-MB.", "output": {"entities": {"gene": [{"text": "CK-MB", "start": 12, "end": 17}, {"text": "CPK", "start": 47, "end": 50}, {"text": "total-CPK", "start": 64, "end": 73}, {"text": "CK-MB", "start": 138, "end": 143}]}}, "schema": []}
{"input": "Value of determination of alkaline phosphatase isoenzymes for differential diagnosis of obstructive jaundice and biliary liver cirrhosis", "output": {"entities": {"gene": [{"text": "alkaline phosphatase isoenzymes", "start": 26, "end": 57}]}}, "schema": []}
{"input": "Several free 2nd-generation schizonts, which varied in diameter from 11 to 21. 6 micrometer, were found on the epithelial surface of the cecum.", "output": {"entities": {}}, "schema": []}
{"input": "The calculated pD2 values were 8. 8 for E, 8. 6 for DHE and 6. 6 for M.", "output": {"entities": {}}, "schema": []}
{"input": "Newcastle disease virus surveillance in Hong Kong on local and imported poultry.", "output": {"entities": {}}, "schema": []}
{"input": "It was postulated that persistent challenge by M. leprae or its antigens to the IgA immunocytes of the intestinal epithelium might have induced tolerance leading to IgA deficiency and subsequent subtotal atrophy of the intestinal villi in the patients with lepromatous leprosy.", "output": {"entities": {"gene": [{"text": "IgA", "start": 80, "end": 83}, {"text": "IgA", "start": 165, "end": 168}]}}, "schema": []}
{"input": "Treatment of hypertension with a combination of the adrenergic beta receptor blockader, obsidan, and the vasodilator, apressin", "output": {"entities": {"gene": [{"text": "adrenergic beta receptor", "start": 52, "end": 76}]}}, "schema": []}
{"input": "Orthop.", "output": {"entities": {}}, "schema": []}
{"input": "Thyroid disease and pregnancy.", "output": {"entities": {}}, "schema": []}
{"input": "To minimize reflux into the blind loop, a number of technical steps are considered indispensable: 1) fluted section of the jejunal stump; 2) isoperistaltic construction of the anastomosis and, particularly, 3) the creation of a single or double valve system upstream from the anastomosis by spiral introflexion of the mucosa using seroserous stitches parallel and perpendicular to the ileal lumen.", "output": {"entities": {}}, "schema": []}
{"input": "At this stage, the eventual high mortality of acute ischemia is established whatever the urgency of the operation or the skill with which it is performed.", "output": {"entities": {}}, "schema": []}
{"input": "Pathogens (Staphylococcus aureus or Gram-negative bacilli) were isolated from only one member of staff in small numbers and irregularly and rarely in large numbers from patients.", "output": {"entities": {}}, "schema": []}
{"input": "Reaction times to tachistoscopically presented stimuli in diabetics", "output": {"entities": {}}, "schema": []}
{"input": "Two out of five patients undergoing selective spinal arteriography developed transient neurological complications during the injection of Urografin 310 M.", "output": {"entities": {}}, "schema": []}
{"input": "The data indicate a three-phase reaction after B1 injection: Phase 1--shortly after injection there is a drop of all parameters lasting for 30 sec.", "output": {"entities": {}}, "schema": []}
{"input": "Serum relaxin levels in prostaglandin E2 induced abortions.", "output": {"entities": {"gene": [{"text": "Serum relaxin", "start": 0, "end": 13}]}}, "schema": []}
{"input": "A--A natural hydrostatic phenomenon, at the level of the ends of the plantar arcs, diffuses body weight, as PAIN plays the role of outsentry (fig.--1) (5); B--Plantar perforating ulceration (PPU) is caused by a combination of INSENSITIVITY and TRAUMATIS (1); C--The patient reposing, as body weight (traumatism) effects disappear, cicatrization process can be easily observed; D--PNEUMATIC INSOLE, being elastic, diffuses localized compression at the ends of the plantar arcs, reduces attrition, makes easier blood circulation, as well as cure and prophylaxis of PPU (fig.--6) (3).", "output": {"entities": {}}, "schema": []}
{"input": "Effect of indoramin in small doses on the central vasomotor loci has been studied in chloralose anesthetized cats by localizing it to the central sites.", "output": {"entities": {}}, "schema": []}
{"input": "Contingency contracting between clients and their parents/caregivers was used to specify consequences for daily self-monitoring, reduced caloric intake, weight loss, and exercise.", "output": {"entities": {}}, "schema": []}
{"input": "Dietetics of childhood-and juvenile diabetes", "output": {"entities": {}}, "schema": []}
{"input": "The results of a quantitative study of vasculosyncytial membranes in 123 placentas are presented.", "output": {"entities": {}}, "schema": []}
{"input": "The micromethod uses microcuvettes and substitutes ferrozine for the bathophenanthroline chromogen of the ICSH.", "output": {"entities": {}}, "schema": []}
{"input": "Platelet serotonin (5-HT) and 5-HT releasing factor in plasma of migrainous patients.", "output": {"entities": {"gene": [{"text": "5-HT releasing factor", "start": 30, "end": 51}]}}, "schema": []}
{"input": "The vigilance task and the measurement of attentional deficits.", "output": {"entities": {}}, "schema": []}
{"input": "The December armed revolt in Moscow and the paramedical personnel", "output": {"entities": {}}, "schema": []}
{"input": "The motor unit viewed from above.", "output": {"entities": {}}, "schema": []}
{"input": "Avian reproductive system: daily variations in responses to hormones.", "output": {"entities": {}}, "schema": []}
{"input": "Biological properties of sumithion.", "output": {"entities": {}}, "schema": []}
{"input": "Serological studies of antibodies to Epstein-Barr virus in infectious mononucleosis", "output": {"entities": {}}, "schema": []}
{"input": "Carcinoembryonic antigen (CEA) procedures and clinical evaluation.", "output": {"entities": {"gene": [{"text": "Carcinoembryonic antigen", "start": 0, "end": 24}, {"text": "CEA", "start": 26, "end": 29}]}}, "schema": []}
{"input": "On the basis of a global assessment patients showed a highly significant preference for imipramine compared with placebo as adjunctive therapy.", "output": {"entities": {}}, "schema": []}
{"input": "39-47.", "output": {"entities": {}}, "schema": []}
{"input": "Absorption varied between 65 and 95 per cent, with a mean absorption of 80 per cent, in both pregnant and non-pregnant subjects.", "output": {"entities": {}}, "schema": []}
{"input": "Advances in the management of gynecologic cancer--radiation therapy.", "output": {"entities": {}}, "schema": []}
{"input": "The clinico-pathological data from a patient with irreversible post-partum renal failure (IPRF) are presented.", "output": {"entities": {}}, "schema": []}
{"input": "Dialyzable transfer factor.", "output": {"entities": {"gene": [{"text": "transfer factor", "start": 11, "end": 26}]}}, "schema": []}
{"input": "19-32.", "output": {"entities": {}}, "schema": []}
{"input": "Rheumatoid factor and antinuclear antibody tests were frequently positive, and reactions to gold therapy were more frequent than in other rheumatoid populations.", "output": {"entities": {"gene": [{"text": "Rheumatoid factor", "start": 0, "end": 17}]}}, "schema": []}
{"input": "This report presents an analysis of the vocal repertoire of howler monkeys (Alouatta palliata) observed during a field study in southwestern Panama.", "output": {"entities": {}}, "schema": []}
{"input": "Up to now the number of patients examined is about 300, additionally 6 persons who underwent binephrectomy.", "output": {"entities": {}}, "schema": []}
{"input": "Deflunia was well tolerated by 25 patients, very well tolerated by 2.", "output": {"entities": {}}, "schema": []}
{"input": "III.", "output": {"entities": {}}, "schema": []}
{"input": "A new instrument has been designed for freeze-fracturing of biological material in ultra high vacuum.", "output": {"entities": {}}, "schema": []}
{"input": "Pancreatic and biliary secretion and gastric emptying rates of a liquid test meal (LTM) were determined in normal persons, in patients with subtotal gastrectomy with gastroduodenostomy (STG-BI) or with gastrojejunostomy (STG-BII), and in patients with truncal vagotomy and pyloroplasty (V & P).", "output": {"entities": {}}, "schema": []}
{"input": "Also, except in one patient who developed gallstones following institution of colestipol, saturation of gallbladder bile with cholesterol was not markedly increased by this drug alone.", "output": {"entities": {}}, "schema": []}
{"input": "A diagnosis of MS was made based on subtle neurologic signs, spinal fluid gamma globulin elevations, and abnormalities in neuropsychological testing.", "output": {"entities": {"gene": [{"text": "gamma globulin", "start": 74, "end": 88}]}}, "schema": []}
{"input": "If, however, the mean temperature rise was higher (0. 57 degrees C or 0. 69 degrees C), such a selection practically resulted in the disappearance of' passable' qualifications in the triplet groups and a great predominance of' to be rejected' qualifications in the large groups.", "output": {"entities": {}}, "schema": []}
{"input": "The elevated Viso V in the RDS group suggests an increase in small airway resistance secondary to the disease or to its therapy.", "output": {"entities": {}}, "schema": []}
{"input": "The psychological tests consisted of a free-recall task, a test for visuomotor coordination and a recognition task.", "output": {"entities": {}}, "schema": []}
{"input": "Selective bronchial intubation in the management of unilateral pulmonary interstitial emphysema.", "output": {"entities": {}}, "schema": []}
{"input": "The background processes depending on the etiological factor and the character of lesion of the epithelium are divided into dyshormonal, inflammatory, and posttraumatic.", "output": {"entities": {}}, "schema": []}
{"input": "The sense of self.", "output": {"entities": {}}, "schema": []}
{"input": "Eleven strains of Fusarium poae and F. sporotrichioides from the U. S. S. R. and 7 strains of these species and one of F. sporotrichioides var. tricinctum from U. S. A. and France have been compared as to their capacity to yield T-2 toxin.", "output": {"entities": {"gene": [{"text": "T-2 toxin", "start": 229, "end": 238}]}}, "schema": []}
{"input": "Current diagnostic uses of computerized tomography in clinical medicine.", "output": {"entities": {}}, "schema": []}
{"input": "A follow-up study of 22 patients with Ebstein' s anomaly has been performed.", "output": {"entities": {}}, "schema": []}
{"input": "Deaths stopped 11 hours after copper concentrations decreased below 0. 2 ppm and signs of distress stopped in surviving pinfish by approximately 6 hours after the last death.", "output": {"entities": {}}, "schema": []}
{"input": "Recurrence of bladder tumors among the original 9 cases has occurred only among the 5 whose properdin levels remained below the median.", "output": {"entities": {"gene": [{"text": "properdin", "start": 92, "end": 101}]}}, "schema": []}
{"input": "Adaptation of taurocholate transport maximum to increased secretory load in the rat.", "output": {"entities": {}}, "schema": []}
{"input": "Dangers in use of live-virus vaccines.", "output": {"entities": {}}, "schema": []}
{"input": "Treatment with heparin, plasminogen activators and fibrinogenolytic agents was disappointing although renal function has stabilized in one patient on long term oral anticoagulant therapy.", "output": {"entities": {"gene": [{"text": "plasminogen", "start": 24, "end": 35}]}}, "schema": []}
{"input": "In diethyl ether solution the main peak is that of 2-benzylidenamio-1-phenylpropane, which has a retention time of 23, 2 minutes under the condition delineated.", "output": {"entities": {}}, "schema": []}
{"input": "Amikacin was used in the treatment of 56 serious gram-negative infections in 54 patients of whom 47 survived.", "output": {"entities": {}}, "schema": []}
{"input": "The data normally available are insufficient and take no account of the direction of recirculation, which may be a determining factor.", "output": {"entities": {}}, "schema": []}
{"input": "The acids were obtained by hydrolysis of the corresponding esters, and their anti-inflammatory activity was tested.", "output": {"entities": {}}, "schema": []}
{"input": "Unrecognized amnionitis and prematurity: a preliminary report.", "output": {"entities": {}}, "schema": []}
{"input": "Evaluation of the new Gravigard IUCD inserter.", "output": {"entities": {}}, "schema": []}
{"input": "Bacterial meningitis secondary to abscess of the nasal septum.", "output": {"entities": {}}, "schema": []}
{"input": "Serum amylase became markedly elevated (2, 624 CU/100 ml), as did the serum FFA (29. 19 mEq/liter).", "output": {"entities": {"gene": [{"text": "Serum amylase", "start": 0, "end": 13}]}}, "schema": []}
{"input": "In the control preparation before weight was allowed to increase, isogravimetric capillary pressure (Pci) averaged 8 mmHg lower than colloid osmotic pressure of the plasma (IIp).", "output": {"entities": {}}, "schema": []}
{"input": "The morphological effects of two snake venoms, N. naja and A. piscivorus, and of the Direct Lytic Factor and Phospholipase-A, compounds purified from N. naja crude venom, were investigated on lung and cremaster vessels of rats.", "output": {"entities": {"gene": [{"text": "Direct Lytic Factor", "start": 85, "end": 104}, {"text": "Phospholipase-A", "start": 109, "end": 124}]}}, "schema": []}
{"input": "Since GAGs are the components of cartilage matrix, the depletion of which is associated with osteoarthrosis, a method for measuring sulphated GAG synthesis in culture has been investigated.", "output": {"entities": {}}, "schema": []}
{"input": "The length scales of the turbulence were also estimated: at a Reynolds number near 4, 000 the macroscale is about 1. 25 mm, the Taylor microscale is about 0. 85 mm, and the Kolmogoroff scale is near 0. 075 mm.", "output": {"entities": {}}, "schema": []}
{"input": "Well-visualised arteriograms of the limbs can be obtained by xeroradiography after rapid manual injection of contrast-medium into an arm vein, as demonstrated in 28 patients.", "output": {"entities": {}}, "schema": []}
{"input": "No hypotension was noted in patients with toxemia and only 2 ran a fever above 37. 5 degrees C.", "output": {"entities": {}}, "schema": []}
{"input": "The sera and nasal secretions of 142 patients, who were positive in HD or mites skin test, were subjected to a radioallergosorbent test (RAST) for estimating the specific IgE antibody activity to mites.", "output": {"entities": {"gene": [{"text": "IgE antibody", "start": 171, "end": 183}]}}, "schema": []}
{"input": "Diallylnitrosamine (DAN), one of the few nitrosamines tested thus far that has not induced neoplasms in rats, caused a high incidence of respiratory tract tumors in Syrian golden hamsters treated sc with single or weekly doses of the compound.", "output": {"entities": {}}, "schema": []}
{"input": "Haemodynamic responses to antagonism of bocurarine block with atropine-neostigmine mixture in children.", "output": {"entities": {}}, "schema": []}
{"input": "The mechanism by which large molecules, such as the diphosphonate 99mTc-labeled EHDP or 99mTc-labeled pyrophosphate, pass through capillaries in bone is by passive diffusion.", "output": {"entities": {}}, "schema": []}
{"input": "Twenty-nine days after injection of 5. 8 mCi of Tc-99m, which gives 28 rads to the testis, the number of sperm hads decreased to 70% of control.", "output": {"entities": {}}, "schema": []}
{"input": "Self-emasculation is the end result of an unusual psychiatric disorder, which initially requires surgical treatment.", "output": {"entities": {}}, "schema": []}
{"input": "Possibility of a TSH-Screening method for detection of hypothyroidism in the newborn", "output": {"entities": {"gene": [{"text": "TSH", "start": 17, "end": 20}]}}, "schema": []}
{"input": "Thus analysis indicated no reliable evidence that conscious presleep suggestions become incorporated into dream content.", "output": {"entities": {}}, "schema": []}
{"input": "The prevalence of hepatitis B surface antigen (HBsAg) and anti-HBs was determined by a sensitive double-antibody radio-immunoassay technique in a series of patients with chronic liver diseases.", "output": {"entities": {"gene": [{"text": "hepatitis B surface antigen", "start": 18, "end": 45}, {"text": "HBsAg", "start": 47, "end": 52}, {"text": "anti-HBs", "start": 58, "end": 66}]}}, "schema": []}
{"input": "Decreased cardiac glycogen following phenformin injection in hyperglycemic, hyperinsulinemic anaesthetized rats.", "output": {"entities": {}}, "schema": []}
{"input": "Biological evaluation of mibolerone in the female Beagle.", "output": {"entities": {}}, "schema": []}
{"input": "Levels of both PGF and PGFM were significantly higher during early spontaneous labour, at a cervical dilatation of less than 4 cm, than before the onset of labour.", "output": {"entities": {}}, "schema": []}
{"input": "Propranolol (Inderal) administered in a dose which blocks the beta-adrenergic apparatus of the heart prevents the development of the positive inotropic effect of therapeutic doses of strophanthin K on a hypodynamic left ventricular myocardium.", "output": {"entities": {}}, "schema": []}
{"input": "Recent studies have shown the rat larynx to be an important organ in the evaluation of irritancy of inhaled materials.", "output": {"entities": {}}, "schema": []}
{"input": "Scanning electron microscopic investigations on the formation of Reissner' s fiber in Rattus rattus", "output": {"entities": {}}, "schema": []}
{"input": "Feeding behavior, circannual body weight and hibernation rhythms in European hamsters lesioned in the noradrenergic ascending bundles", "output": {"entities": {}}, "schema": []}
{"input": "Role of the infectious-disease specialist of a polyclinic in reducing the incidence of communicable diseases", "output": {"entities": {}}, "schema": []}
{"input": "These observed drug interactions, plus the known effect of probenecid to block secretion of PZA, have to be considered in evaluating the effect of the two drugs given together, compared to the effect of each drug given separately.", "output": {"entities": {}}, "schema": []}
{"input": "At a systolic blood pressure (BP) of 60 mmHg, C02 responsiveness was abolished, but was maintained at higher levels of BP.", "output": {"entities": {}}, "schema": []}
{"input": "On cessation of steroid therapy the patient was noted to have radiologic manifestations of hypertrophic osteoarthropathy (HOA) as well as clinical and laboratory features of rheumatoid arthritis (RA).", "output": {"entities": {}}, "schema": []}
{"input": "The effect of food on procainamide absorption.", "output": {"entities": {}}, "schema": []}
{"input": "After giving a survey on the situation of antibiotic resistance in the region of Northern Bavaria during 1973/74 and comparing the activity of a sulfamethoxazole (SMZ) trimethoprim (TMP) combination to other commonly used antibiotics and chemotherapeutic agents, the results of tests with the new combination of N1-(4, 5-dimethyl-2-oxazolyl)-sulfanilamide) (sulfamoxole) and 2, 4-diamino-5-(3, 4, 5-trimethoxy-benzyl)-pyrimidine (trimethoprim) at a ratio of 5: 1 (CN 3123; Nevin, Supristol) are compared to those of tests with TMP/SMZ.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: Total IgE levels showed a tendency to diminish.", "output": {"entities": {"gene": [{"text": "IgE", "start": 15, "end": 18}]}}, "schema": []}
{"input": "Does afferent loop syndrome exist?] It is the author' s opinion that diagnosis of the \" adducent loop syndrome \" is unlikely to be correct in patients subjected to Billroth-II gastrectomy.", "output": {"entities": {}}, "schema": []}
{"input": "Letter: Is actinic (solar) damage the provoking cause of' post-inflammatory elastolysis and cutis laxa (PECL)'?", "output": {"entities": {}}, "schema": []}
{"input": "These data suggest that spontaneous recovery of central respiratory function after intoxication with Soman or Sarin may not be related to the return of AChE activity.", "output": {"entities": {"gene": [{"text": "AChE", "start": 152, "end": 156}]}}, "schema": []}
{"input": "Batch cultures of S. mutans serotype a demonstrated no growth on MSB agar.", "output": {"entities": {}}, "schema": []}
{"input": "Crisis of the therapeutic community in Great Britain", "output": {"entities": {}}, "schema": []}
{"input": "Pregnant women at term had the lowest levels of antithrombin III.", "output": {"entities": {"gene": [{"text": "antithrombin III", "start": 48, "end": 64}]}}, "schema": []}
{"input": "Hematology problem of the month: band or seg?", "output": {"entities": {}}, "schema": []}
{"input": "It is possible that cyclic variations in heme turnover are related to changes in erythrocyte characteristics during the progesterone phase.", "output": {"entities": {}}, "schema": []}
{"input": "Haemodilution in cardiopulmonary bypass using a gelatine derivative for priming.", "output": {"entities": {}}, "schema": []}
{"input": "I.", "output": {"entities": {}}, "schema": []}
{"input": "The performance of three commonly used chemical cartridge respirators for SO2 was measured under working conditions in a copper smelter.", "output": {"entities": {}}, "schema": []}
{"input": "The neuroleptic-induced increase in central DA turnover (an indicator for the degree of DA receptor blocking) was found to be positively correlated with the therapeutic effect of neuroleptics and the development of hypokinetic-rigid symptoms.", "output": {"entities": {"gene": [{"text": "DA receptor", "start": 88, "end": 99}]}}, "schema": []}
{"input": "Rainbow trout were obtained from a commercial trout farm, kept in running water and feeding in experimental pellets for 4 to 8 weeks.", "output": {"entities": {}}, "schema": []}
{"input": "Stimulation of macrophage function by killed Bordetella pertussis cells did not show any beneficial effect as an increased susceptibility became apparent.", "output": {"entities": {}}, "schema": []}
{"input": "Primary amenorrhoea in a phenotypically female individual with a karyotype 46, xy and bilateral gonadoblastoma", "output": {"entities": {}}, "schema": []}
{"input": "Toward absolute methods in clinical chemistry: application of mass fragmentography to high-accuracy analyses.", "output": {"entities": {}}, "schema": []}
{"input": "Application of the 2-deoxy-D-glucose method to the coupling of cerebral metabolism and blood flow.", "output": {"entities": {}}, "schema": []}
{"input": "Serum gastrin levels did not change in either group; however, background serum gastrin concentrations were significantly greater for V & P patients than V & A patients throughout the study.", "output": {"entities": {"gene": [{"text": "gastrin", "start": 6, "end": 13}, {"text": "gastrin", "start": 79, "end": 86}]}}, "schema": []}
{"input": "Efferent projections of the ventral portion of the putamen to the frontal, parietal and temporal regions of the cat cerebral cortex", "output": {"entities": {}}, "schema": []}
{"input": "Preflight, inflight, and postflight exercise response tests were conducted on the astronauts of the second Skylab mission (Skylab 3) as part of an evaluation of physiological adaptation to long-term weightlessness.", "output": {"entities": {}}, "schema": []}
{"input": "Mean corpuscular hemoglobin concentrations remained normal for 48 h and then decreased in both groups, the CO2 group showing the larger decrease.", "output": {"entities": {"gene": [{"text": "corpuscular hemoglobin", "start": 5, "end": 27}]}}, "schema": []}
{"input": "All Cu values obtained from the organs investigated had reached a saturation level at 8 mug Cu/g diet with the exception of the values for body Cu found in the dams that were killed on the day of delivery.", "output": {"entities": {}}, "schema": []}
{"input": "The effect of calcitonin, a large amount of calcium given orally, pentagastrin and glucagon on plasma 47Ca radioactivity curves in subjects pretreated with 47Ca was examined.", "output": {"entities": {"gene": [{"text": "calcitonin", "start": 14, "end": 24}, {"text": "glucagon", "start": 83, "end": 91}]}}, "schema": []}
{"input": "State of the body in disorders of diurnal physiological rhythms and long-term hypokinesia", "output": {"entities": {}}, "schema": []}
{"input": "The response of the plasma fibrinogen level to the subucutaneous injection of turpentine and to the intravenous injection of endotoxin was measured in normal rabbits and in rabbits made granulocytopenic and thrombocytopenic with busulfan.", "output": {"entities": {"gene": [{"text": "plasma fibrinogen", "start": 20, "end": 37}]}}, "schema": []}
{"input": "Constantly rectilinear pressure curves without uterine activities are interpreted as characteristic tocographic criteria of an advanced ectopic gravidity.", "output": {"entities": {}}, "schema": []}
{"input": "Since myoglobin is co-extracted with the hemoglobin, the 2 heme pigments are separated in one portion of the extract by precipitating the hemoglobin in an 85% (NH4) 2SO4 solution.", "output": {"entities": {"gene": [{"text": "myoglobin", "start": 6, "end": 15}, {"text": "hemoglobin", "start": 41, "end": 51}, {"text": "hemoglobin", "start": 138, "end": 148}]}}, "schema": []}
{"input": "Considering these sources of error some of the variability in the present investigation might be avoided by systematic instructions.", "output": {"entities": {}}, "schema": []}
{"input": "E 50, 843 (1994)].", "output": {"entities": {}}, "schema": []}
{"input": "Six patients with the diagnosis of acute mania were treated with high doses of the beta-adrenergic blocking agent propranolol.", "output": {"entities": {}}, "schema": []}
{"input": "Effect of trauma on plasma glucagon and insulin concentrations in sheep.", "output": {"entities": {"gene": [{"text": "plasma glucagon", "start": 20, "end": 35}, {"text": "insulin", "start": 40, "end": 47}]}}, "schema": []}
{"input": "With the help of a nomogram one can read off the refraction, when axis length and corneal curvature are known.", "output": {"entities": {}}, "schema": []}
{"input": "This up-grading of the final score by the CA component is greater (3-8%) in the less able students with scores below the mean level.", "output": {"entities": {}}, "schema": []}
{"input": "Compared to controls, both UB and OCS rats showed a small but significant post-operative reduction in the nocturnality of drinking.", "output": {"entities": {}}, "schema": []}
{"input": "Effect of indomethacin on coronary circulation: effect on ECG tracing", "output": {"entities": {}}, "schema": []}
{"input": "Dual innervation of fast fibers in trunk muscles of lamprey larvae", "output": {"entities": {}}, "schema": []}
{"input": "The feed consumed which was lowered by 25% initially, did not alter later.", "output": {"entities": {}}, "schema": []}
{"input": "Certain characteristics of eye changes in patients with pheochromocytoma including Sipple' s syndrome", "output": {"entities": {}}, "schema": []}
{"input": "The color-word interference effect previously reported with normal populations when given the Stroop test was demonstrated for this retarded sample using a special format.", "output": {"entities": {}}, "schema": []}
{"input": "It was found that under the selected conditions a linear dependence exists between the betaI% value and lgC within the range of 0. 5--10 mug ruscogenin.", "output": {"entities": {}}, "schema": []}
{"input": "The influence of adrenergic nerves of the response of blood vessels in the rabbit ear to 2--phenylalanine-8-lysine vasopressin (Octapressin).", "output": {"entities": {"gene": [{"text": "2--phenylalanine-8-lysine vasopressin", "start": 89, "end": 126}, {"text": "Octapressin", "start": 128, "end": 139}]}}, "schema": []}
{"input": "Potscoital test", "output": {"entities": {}}, "schema": []}
{"input": "When a tumour is present nipple discharge is of little importance for the diagnosis and treatment.", "output": {"entities": {}}, "schema": []}
{"input": "Studies of biochemical and morphological changes (between normal and treated animals) show that chrysotile induces an increase in the lung free cell population and pulmonary surfactant levels.", "output": {"entities": {}}, "schema": []}
{"input": "Infrared measurements of temperature changes and estimates of the heating produced at the mical.", "output": {"entities": {}}, "schema": []}
{"input": "Who says' National Health Dis-service'.", "output": {"entities": {}}, "schema": []}
{"input": "Is criticism of patient care justified and does it have educational value? Patients' criticism contributes to improved patient care", "output": {"entities": {}}, "schema": []}
{"input": "Critique of \" Interactive Effects of Test Anxiety and Credit/No Credit or A-F Grade Condition upon Short-term and Long-term Recall of Course Information.", "output": {"entities": {}}, "schema": []}
{"input": "These studies have shown that the majority of tested staphylococci were resistant to penicillin G, erythromycin, and produced beta-lactamase.", "output": {"entities": {"gene": [{"text": "beta-lactamase", "start": 126, "end": 140}]}}, "schema": []}
{"input": "Improvement of nursing instruction to be given at the time of discharge from the ward for premature infants", "output": {"entities": {}}, "schema": []}
{"input": "No difference in the clinical acceptability could be ascertained between the two groups.", "output": {"entities": {}}, "schema": []}
{"input": "After 90 d a subsurface, radiolucent caries-like lesion was observed in two specimens only.", "output": {"entities": {}}, "schema": []}
{"input": "Plethysmographic technique and indirect blood pressure recordings were used.", "output": {"entities": {}}, "schema": []}
{"input": "The second and third responded similarly to either a combined cyclophosphamide + antilymphocyte globulin (ALG) treatment or to ALG administration preceded by a small dosage of cyclophosphamide, which had proved ineffective when administered alone.", "output": {"entities": {"gene": [{"text": "antilymphocyte globulin", "start": 81, "end": 104}, {"text": "ALG", "start": 106, "end": 109}, {"text": "ALG", "start": 127, "end": 130}]}}, "schema": []}
{"input": "Evidence is presented that Leber' s military aneurysm retinitis is not a separate entity but a special form of Coats' disease.", "output": {"entities": {}}, "schema": []}
{"input": "Fibrin cloaking along the catheter was found in 20 patients studied by pull-out arteriography and was unassociated with clinical symptoms.", "output": {"entities": {"gene": [{"text": "Fibrin", "start": 0, "end": 6}]}}, "schema": []}
{"input": "The influence of a mobile pupil on the response in the DC-ERG is demonstrated.", "output": {"entities": {}}, "schema": []}
{"input": "A newly synthesized anti-inflammatory agent, Y-8004 demonstrated a greater inhibition than did indomethacin (IM). on inflammatory response such as ultraviolet erythema in guinea pigs, carrageenin edema, evans blue and carrageenin-induced pleuritis and acetic acid-induced peritonitis in rats.", "output": {"entities": {}}, "schema": []}
{"input": "As stands shifted in dominance from pine to fir with age, subalpine fir appeared to maintain gradually increasing rates of whole-forest productivity until stands were approximately 400 years old.", "output": {"entities": {}}, "schema": []}
{"input": "Alpha-1 antitrypsin and Indian childhood cirrhosis.", "output": {"entities": {"gene": [{"text": "Alpha-1 antitrypsin", "start": 0, "end": 19}]}}, "schema": []}
{"input": "Lymphocyte subpopulations, serum IgE and total eosinophil counts in patients with bronchial asthma.", "output": {"entities": {"gene": [{"text": "serum IgE", "start": 27, "end": 36}]}}, "schema": []}
{"input": "A range of normal ventricular measurements for the EMI scan is suggested.", "output": {"entities": {}}, "schema": []}
{"input": "A comparison of physical and cytogenetic estimates of radiation dose in patients treated with iodine-131 for thyroid carcinoma.", "output": {"entities": {}}, "schema": []}
{"input": "Technique for obtaining refined ceramics with dense mass", "output": {"entities": {}}, "schema": []}
{"input": "Mean total lung capacity, functional residual capacity, and residual volume increased significantly, and the mean closing volume, the lung volume above residual volume at which phase IV begins, decreased significantly with 11 cm H20 continuous positive airway pressure; differences at 5 cm H20 were not significant.", "output": {"entities": {}}, "schema": []}
{"input": "Current status of zinc deficiency in the pathogenesis of neurological, dermatological and musculoskeletal disorders.", "output": {"entities": {}}, "schema": []}
{"input": "Calcium and phosphorus metabolism in chronic uremia.", "output": {"entities": {}}, "schema": []}
{"input": "Modern studies, conducted with Delta-9-THC, in healthy voluntaries, again suggest the comparison or even the identity of the modifications caused by cannabis with sleep and dream.", "output": {"entities": {}}, "schema": []}
{"input": "The correcting action of tropatepine hydrochloride upon the extrapyramidal effects induced by neuroleptics has been studied in 32 acute psychotic states.", "output": {"entities": {}}, "schema": []}
{"input": "Epididymal growth was retarded in animals maintained solely on chickpea haulm and improved with supplementation.", "output": {"entities": {}}, "schema": []}
{"input": "Two patients were treated with both regimens.", "output": {"entities": {}}, "schema": []}
{"input": "Results obtained for chloramphenicol-containing preparations are presented, and both dissolution curves and cup-plate assays demonstrate that chloramphenicol has far superior release (and hence activity) from creams than from ophthalmic ointments.", "output": {"entities": {}}, "schema": []}
{"input": "IgG levels of 1/100 were present in only four out of ten samples obtained 150 days after the clinical onset.", "output": {"entities": {"gene": [{"text": "IgG", "start": 0, "end": 3}]}}, "schema": []}
{"input": "Letter: Perspectives in bone marrow transplantation.", "output": {"entities": {}}, "schema": []}
{"input": "Assessment of the carcinogenicity of non-nutritive sweetners II: Cyclamates and cyclohexylamine.", "output": {"entities": {}}, "schema": []}
{"input": "The discordant behaviour in weakly infected mice was due to the occurrence in some animals of a second phase of more rapid increase of the parasitemia.", "output": {"entities": {}}, "schema": []}
{"input": "Residual amphotericin B was detected in the feces of the mice only while they were receiving the 0. 3 mg/ml dose level.", "output": {"entities": {}}, "schema": []}
{"input": "There was a slight increase in total transferrin 2 hr after 1 tablet and values remained high throughout the experiment.", "output": {"entities": {"gene": [{"text": "transferrin", "start": 37, "end": 48}]}}, "schema": []}
{"input": "Following intravenous administration, the myocardial concentration of tracer thallium-201, potassium-43, and rubidium-81 were determined in mice; thallium was present in the greatest concentration in the myocardium (2. 08% compared 1. 25% for potassium and 1. 15% for rubidium at 10 minutes).", "output": {"entities": {}}, "schema": []}
{"input": "Thromboplastin time, partial thromboplastin time, thrombin time, heat-dependent fibrin, clot retraction, and clotting factors II, V, VIII, IX, X, and the platelet count were determined.", "output": {"entities": {"gene": [{"text": "Thromboplastin", "start": 0, "end": 14}, {"text": "thromboplastin", "start": 29, "end": 43}, {"text": "thrombin", "start": 50, "end": 58}, {"text": "fibrin", "start": 80, "end": 86}, {"text": "clotting factors II, V, VIII, IX, X", "start": 109, "end": 144}]}}, "schema": []}
{"input": "The data support the notion that suppression of images during binocular rivalry is independent in both eyes.", "output": {"entities": {}}, "schema": []}
{"input": "Glycogen utilization was increased, but tissue levels of creatine phosphate, ATP, and lactate were similar to those in hearts receiving normal flow.", "output": {"entities": {}}, "schema": []}
{"input": "The records from 1948 through 1967 of 344 previously untreated patients with squamous cell carcinoma of the oral cavity, oropharynx, supraglottic larynx and hypopharynx who had clinically positive cervical lymph node metastases staged N1, N2A, or N2B, and whose initial neck treatment consisted of external radiation therapy alone were reviewed.", "output": {"entities": {}}, "schema": []}
{"input": "With 0. 5 vol.-%, the corresponding values were 345 mumol/1 (5. 72 mg/100 ml) and 137 mumol/1 (2. 25 mg/100 ml) respectively.", "output": {"entities": {}}, "schema": []}
{"input": "The authors describe the technique of transverse axial tomography of the spine and give a detailed description of the axial anatomy of the normal lumbar spine from L-4 to the sacrum.", "output": {"entities": {}}, "schema": []}
{"input": "Owing to parental attitude, a low protein diet (1-5 g/kg) was introduced only late.", "output": {"entities": {}}, "schema": []}
{"input": "In none of the 44 type I attacks and 29 type II attacks which were recorded did circulatory changes; the latter were different in the two groups.", "output": {"entities": {}}, "schema": []}
{"input": "A clinically useful diagnostic method has been developed for detecting and quantitating periods of apnea in pediatric patients.", "output": {"entities": {}}, "schema": []}
{"input": "The other hypoglycaemic patient showed an exaggerated insulin release in response to tolbutamide.", "output": {"entities": {"gene": [{"text": "insulin", "start": 54, "end": 61}]}}, "schema": []}
{"input": "Effect of ingestion of Norbiogest during the quiescent period of the genital organs", "output": {"entities": {}}, "schema": []}
{"input": "Bulbar pouches were perfused with solutions of 0. 9% Na C1, 0. 1 N HC1, 40% glucose, 40% NaC1, and 40% peptone or with 0. 1% solutions of acetylcholine chloride.", "output": {"entities": {}}, "schema": []}
{"input": "Liver microsomes of the shag showed smaller than 8% of the epoxide hydrase activity and smaller than 14% of the hydroxylating capacity of liver microsomes from the rat.", "output": {"entities": {"gene": [{"text": "epoxide hydrase", "start": 59, "end": 74}]}}, "schema": []}
{"input": "A clinical, serological and prognostic study", "output": {"entities": {}}, "schema": []}
{"input": "The American Burkitt Lymphoma Registry: a progress report.", "output": {"entities": {}}, "schema": []}
{"input": "Vitrectomy with an alternative instrument system.", "output": {"entities": {}}, "schema": []}
{"input": "The metabolic clearance rate of progesterone was 295 +/-49 (S. E.) 1/day.", "output": {"entities": {}}, "schema": []}
{"input": "The mean plasma sodium concentration which was 135. 95 (+/-SD 4. 14) mEq/kg before diuretic treatment was significantly decreased during treatment to 129. 19 (+/-SD 2. 77) mEq/kg, P less than 0. 001.", "output": {"entities": {}}, "schema": []}
{"input": "Editorial: Low-dose heparin and the prevention of venous thromboembolic disease.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of perceptual salience on the matrix task performance of four-and six-year-old children.", "output": {"entities": {}}, "schema": []}
{"input": "Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency in the newborn.", "output": {"entities": {"gene": [{"text": "Glucose-6-phosphate dehydrogenase", "start": 0, "end": 33}, {"text": "G-6-PD", "start": 35, "end": 41}]}}, "schema": []}
{"input": "The eluting solvent was methanol-chloroform (10 + 90) at a flow rate of 2. 0 ml/min.", "output": {"entities": {}}, "schema": []}
{"input": "The bronchial epithelia of all smoke-exposed animals were hyperplastic, and their ultrastructure showed invaginations, tilt of nuclear axes, an increase in the number and size of lysosomes and multivesiculated bodies, and increased numbers of enlarged intramitochondrial granules.", "output": {"entities": {}}, "schema": []}
{"input": "The routine administration of fat-soluble vitamins appears unnecessary but it is prudent to measure prothrombin time and serum vitamins A and E at intervals.", "output": {"entities": {"gene": [{"text": "prothrombin", "start": 100, "end": 111}]}}, "schema": []}
{"input": "Prostaglandins F (PGF) were measured in uterine vein, ovarian artery, and jugular vein plasma and in the endometrial tissues at various times during the bovine estrous cycle, and were compared to peripheral plasma progesterone levels.", "output": {"entities": {}}, "schema": []}
{"input": "Before this date, the drug directly inhibits fetal weight gain, whereas the sensitivity of the placenta is only transient at day 16 resulting in maximum weight decrease of this organ 24 h later.", "output": {"entities": {}}, "schema": []}
{"input": "Groups of ten dependent and ten saline mice were singly tested in both light and dark conditions in each of five covered cylinders (2-23 in high).", "output": {"entities": {}}, "schema": []}
{"input": "The effects initiated from the nucleus accumbens septi were most marked.", "output": {"entities": {}}, "schema": []}
{"input": "The appearance of dyskinetic movement disorders in humans following the chronic use of levodopa or amphetamine may be a manifestation of similarly increased dopamine receptor site sensitivity within the striatum.", "output": {"entities": {"gene": [{"text": "dopamine receptor site", "start": 157, "end": 179}]}}, "schema": []}
{"input": "Association with HL-A W-27.", "output": {"entities": {"gene": [{"text": "HL-A W-27", "start": 17, "end": 26}]}}, "schema": []}
{"input": "Letter: Lactose tolerance tests as a predictor of milk tolerance.", "output": {"entities": {}}, "schema": []}
{"input": "Retinoblastoma: a study of natural history and prognosis of 268 cases.", "output": {"entities": {}}, "schema": []}
{"input": "Like pineal melatonin, serum melatonin was high at mid-dark and low at mid-light.", "output": {"entities": {}}, "schema": []}
{"input": "D.", "output": {"entities": {}}, "schema": []}
{"input": "Atherosclerosis", "output": {"entities": {}}, "schema": []}
{"input": "The authors concluded that ultrasonic Doppler-cardiography can be used for measuring the relative changes in the stroke volume.", "output": {"entities": {}}, "schema": []}
{"input": "The attainment of sexual maturity in terms of secondary sexual characteristics, the production of spermatozoa in the male, and the cyclical female pattern with release of ova are end-points of the developmental process.", "output": {"entities": {}}, "schema": []}
{"input": "Caution should be exercised in the use of these dyes for lymphograms.", "output": {"entities": {}}, "schema": []}
{"input": "This reveals a new test for short saphenous incompetence and shows that 14 per cent of varices stem from a saphenopopliteal reflux.", "output": {"entities": {}}, "schema": []}
{"input": "Three groups of patients who had undergone subtotal thyroidectomy for Graves' s disease, toxic multinodular goitre, or euthyroid multinodular goitre 12 to 15 years before and in whom a normal serum thyroxine (T-4) level was found were each divided into two subgroups on the basis of a normal or a raised serum thyrotrophin concentration.", "output": {"entities": {"gene": [{"text": "thyrotrophin", "start": 310, "end": 322}]}}, "schema": []}
{"input": "Routine isotope cystography using 99M Tc sulfur colloid for detection and follow-up of vesico-ureteral reflux", "output": {"entities": {}}, "schema": []}
{"input": "Air ion action on bacteria.", "output": {"entities": {}}, "schema": []}
{"input": "The interpretation of antibiotic disc sensitivities.", "output": {"entities": {}}, "schema": []}
{"input": "Following retransfusion, the affected epithelial lining appeared greatly distended over the oedematous lamina propria, with almost complete loss of structural detail.", "output": {"entities": {}}, "schema": []}
{"input": "Characteristics of anesthesia and resuscitation in emergency lung surgery", "output": {"entities": {}}, "schema": []}
{"input": "Tobramycin 60 mg did not show any remarkable effect, but dibecacin 100 mg produced a slight potentiating effect on the action of d-tubocurarine.", "output": {"entities": {}}, "schema": []}
{"input": "In about one third of the cases this operation results in tonal and vocal improvement for patients suffering from progressive perceptive deafness.", "output": {"entities": {}}, "schema": []}
{"input": "The specific electrical resistance of the cerebrospinal fluid was measured by means of conductometry in 14 cases of meningitis purulenta, 17 cases of meningitis serosa, 10 cases of encephalitis and in 32 control subjects.", "output": {"entities": {}}, "schema": []}
{"input": "2-Chemical occlusion of vas is quite effective in producing a block in the vas deferens of dogs.", "output": {"entities": {}}, "schema": []}
{"input": "Besides, we found in 3 patients increased serum immunoglobulins, chiefly IgG, as first Russe, Busey and Barbeau demonstrated in a large French-Canadian family.", "output": {"entities": {"gene": [{"text": "serum immunoglobulins", "start": 42, "end": 63}, {"text": "IgG", "start": 73, "end": 76}]}}, "schema": []}
{"input": "We suggest that such occlusions occurred at the time of the infarction.", "output": {"entities": {}}, "schema": []}
{"input": "Streptococcal preparation (OK-432), a new type of anti-cancer agent, was given to the patients with advanced cancer in combination with Mitomycin-C, 5-FU and Cytosine arabinoside.", "output": {"entities": {}}, "schema": []}
{"input": "Generally, a correlation was observed between highest concentrations of CSF immunoglobulins and degree of meningeal inflammatory response, even if this was a component of other neurological diseases.", "output": {"entities": {"gene": [{"text": "CSF immunoglobulins", "start": 72, "end": 91}]}}, "schema": []}
{"input": "Experimental cardiotoxicity of adriamycin", "output": {"entities": {}}, "schema": []}
{"input": "Muscular pathology", "output": {"entities": {}}, "schema": []}
{"input": "Demonstration of the agent was performed from the 6th to the 11th day p. i. by direct microscopic methods (Stamp and auramine staining, fluorescent antibody technique); the Coxiella content was determined by titration in embryonated hen' s eggs.", "output": {"entities": {}}, "schema": []}
{"input": "The patients were divided into 4 groups receiving NLA II with or without nalorphine, morphine or Micoren.", "output": {"entities": {}}, "schema": []}
{"input": "The alterations of 5-HT and 5-HIAA levels in several regions of the brain under the conditions examined may indicate that IDPN' s neurotoxicity primarily affects 5-HT-containing neurones.", "output": {"entities": {}}, "schema": []}
{"input": "(5) An increase in leukocyte-counts occurred on the administration of serum obtained from rabbit during phase-2.", "output": {"entities": {}}, "schema": []}
{"input": "The results obtained tend to prove that the reticuloendothelial system mainly participated in beryllium retention.", "output": {"entities": {}}, "schema": []}
{"input": "The calcium ratio (mean ratio of the predicted to measured TBCa) in men was 1. 000 +/-7. 8% and in women 0. 996 +/-7. 1%.", "output": {"entities": {}}, "schema": []}
{"input": "Total cholesterol was measured in amniotic fluids collected at different stages of gestation.", "output": {"entities": {}}, "schema": []}
{"input": "Her serum FT3 concentration was, however, much higher than the ranges in normal pregnancy or in GTD patients without clinical hyperthyroidism.", "output": {"entities": {}}, "schema": []}
{"input": "The authors found that except for fear and pugnacity all husband-wife trait correlations were positive, in contrast to Winch' s principle of type I complementarity.", "output": {"entities": {}}, "schema": []}
{"input": "A note on the phase-plane technique representation of cardiac action potentials.", "output": {"entities": {}}, "schema": []}
{"input": "3 activities of the factor II molecule in the newborn infant at term", "output": {"entities": {"gene": [{"text": "factor II", "start": 20, "end": 29}]}}, "schema": []}
{"input": "However, we did detect lot-to-lot variation and differences in performance between narrow bandpass and wide bandpass spectrophotometers.", "output": {"entities": {}}, "schema": []}
{"input": "The cochlear compromise.", "output": {"entities": {}}, "schema": []}
{"input": "A case observed in Saigon", "output": {"entities": {}}, "schema": []}
{"input": "Hypertonic glucose administered intrajejunally in Heidenhain pouch dogs resulted in an equal inhibition of pentagastrin-induced acid secretion from the pouch and the main stomach, whereas hypertonic saline had no effect.", "output": {"entities": {}}, "schema": []}
{"input": "Biohydrogenation of linoleic acid into octadecenoic acid was observed.", "output": {"entities": {}}, "schema": []}
{"input": "Chlamydial agents were isolated from the semen near the end of the chlamydemic phase.", "output": {"entities": {}}, "schema": []}
{"input": "Because of the increased CPK activity found in normal newborns, screening for Duchenne-type muscular dystrophy should be postponed for a few weeks after delivery.", "output": {"entities": {"gene": [{"text": "CPK", "start": 25, "end": 28}]}}, "schema": []}
{"input": "In contrast, the insulin response had returned to the non-pregnant value by the second day of the puerperium.", "output": {"entities": {"gene": [{"text": "insulin", "start": 17, "end": 24}]}}, "schema": []}
{"input": "The authors report the results of a series of toxicological tests conducted on plastic materials (polyethylene) activated with tetraphenylbutadiene (TPB) an additive recently proposed as a sensitizer capable of photodegrading plastic materials.", "output": {"entities": {}}, "schema": []}
{"input": "Mutational analysis of the major homology region of Mason-Pfizer monkey virus by use of saturation mutagenesis.", "output": {"entities": {}}, "schema": []}
{"input": "One site, PAL, occurs within the 10 bp sequence GGGGAGGAGG.", "output": {"entities": {"gene": [{"text": "PAL", "start": 10, "end": 13}]}}, "schema": []}
{"input": "Nuclear extracts prepared from both neural and non-neural cell lines, mouse brain, and mouse liver contain proteins that recognize and bind to the PROX and PAL sequences indicating that proteins which bind to these target sequences are widespread.", "output": {"entities": {}}, "schema": []}
{"input": "To determine if the NF (H) promoter can be activated in a tissue specific manner during development transgenic mice containing the promoter region linked to a beta-galactosidase reporter gene were generated.", "output": {"entities": {"gene": [{"text": "NF (H) promoter", "start": 20, "end": 35}, {"text": "beta-galactosidase reporter gene", "start": 159, "end": 191}]}}, "schema": []}
{"input": "Here we describe and map two more new genes identified as allele-specific suppressors that compensate for carboxy-terminal truncation of PET122.", "output": {"entities": {"gene": [{"text": "PET122", "start": 137, "end": 143}]}}, "schema": []}
{"input": "Previous studies have shown [Hisanaga, S., Kusubata, M., Okumura, E. & Kishimoto, T.", "output": {"entities": {}}, "schema": []}
{"input": "Treatment and staining of smears and sections for detection of microorganisms", "output": {"entities": {}}, "schema": []}
{"input": "The apparent Kd of the MetRS/CAU operator complex is one order magnitude higher than that of the ThrRS/CGU operator complex.", "output": {"entities": {"gene": [{"text": "MetRS/CAU operator complex", "start": 23, "end": 49}, {"text": "ThrRS/CGU operator complex", "start": 97, "end": 123}]}}, "schema": []}
{"input": "A significant direct relationship was observed between the percent area density of smooth muscle and the percent change in peak urinary flow rate.", "output": {"entities": {}}, "schema": []}
{"input": "Rabbit skeletal muscle glycogenin.", "output": {"entities": {"gene": [{"text": "Rabbit skeletal muscle glycogenin", "start": 0, "end": 33}]}}, "schema": []}
{"input": "Characterization of the human gene encoding cytokeratin 17 and its expression pattern.", "output": {"entities": {"gene": [{"text": "human gene encoding cytokeratin 17", "start": 24, "end": 58}]}}, "schema": []}
{"input": "Animals that received DSP-4 were significantly retarded in motor recovery compared with the saline group.", "output": {"entities": {}}, "schema": []}
{"input": "The prophylactic use of new medication for patients between the first and second cycle of chemotherapy, in agreement with the estimates calculated, does not save health care costs but may improve the quality of life in these patients and permit the continuation of a therapeutic schedule without interruption which may improve the life expectancy of the patient.", "output": {"entities": {}}, "schema": []}
{"input": "The isolation of this gene was based on the identification of the Y-231 cosmid that contains CpG rich sequences (HTF islands) in its human insert.", "output": {"entities": {}}, "schema": []}
{"input": "Gene constructs consisting of human growth hormone (hGH) gene driven by promoter/regulatory sequence of mouse metallothionein (mMT), viral thymidine kinase (vTK), rat cholecystokinin (rCCK), or chicken beta-actin (cBA) gene were injected into the cytoplasm of fertilized medaka eggs via the micropyle.", "output": {"entities": {"gene": [{"text": "human growth hormone", "start": 30, "end": 50}, {"text": "hGH", "start": 52, "end": 55}, {"text": "mouse metallothionein", "start": 104, "end": 125}, {"text": "mMT", "start": 127, "end": 130}, {"text": "viral thymidine kinase", "start": 133, "end": 155}, {"text": "vTK", "start": 157, "end": 160}, {"text": "rat cholecystokinin", "start": 163, "end": 182}, {"text": "rCCK", "start": 184, "end": 188}, {"text": "chicken beta-actin", "start": 194, "end": 212}, {"text": "cBA", "start": 214, "end": 217}]}}, "schema": []}
{"input": "Serum gastrin and AFP levels had the same evolution and appear to have the same interest to follow the course of the disease.", "output": {"entities": {"gene": [{"text": "gastrin", "start": 6, "end": 13}, {"text": "AFP", "start": 18, "end": 21}]}}, "schema": []}
{"input": "Prospects for controlled-delivery systems.", "output": {"entities": {}}, "schema": []}
{"input": "Though hepatomegaly and mild elevation of enzymes can be observed in a significant proportion of patients, involvement of liver leading to acute hepatitis or liver cell necrosis is a relatively uncommon complication in P. falciparum malaria.", "output": {"entities": {}}, "schema": []}
{"input": "For the first group, the maximal decrease in plasma potassium elicited by salbutamol was 0. 80 +/-0. 19, 0. 48 +/-0. 22, and 0. 78 +/-0. 46 mmol/l, and for the second group, maximal decrement was 1. 31 +/-0. 37, 0. 70 +/-0. 24, and 0. 84 +/-0. 17 mmol/l for the iv, po, and it routes, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "A statistically significant improvement due to the administration of Bromergon was observed in symptoms associated with overreactiveness to normal prolactin levels, i. e. abdominal tension, edema, weight gain and breast tenderness.", "output": {"entities": {"gene": [{"text": "prolactin", "start": 147, "end": 156}]}}, "schema": []}
{"input": "The magnitude of the early response was 241 +/-51% in A (% baseline RL; mean +/-SE), and significantly less in B (119 +/-7%) and C (131 +/-16%) (p < 0. 01).", "output": {"entities": {}}, "schema": []}
{"input": "Most of the patients presented with Transient Ischemic Attacks (64%) or Reversible Ischemic Neurologic Deficits (19%).", "output": {"entities": {}}, "schema": []}
{"input": "This analysis, together with a consideration of the SCBs found upstream of known SWI4, 6-dependent genes, leads to the proposal of a revised consensus sequence for this important regulatory element.", "output": {"entities": {"gene": [{"text": "SWI4, 6", "start": 81, "end": 88}]}}, "schema": []}
{"input": "Mutational analysis of a DNA sequence involved in linking gene expression to the cell cycle.", "output": {"entities": {}}, "schema": []}
{"input": "The natural history of these lesions, locoregional efficiency of the different treatments used, the part played by chemotherapy, survival, causes of death and therapeutic modalities used as a last measure, have been analysed.", "output": {"entities": {}}, "schema": []}
{"input": "The method was adapted for the determination of nadolol racemate A by a change in mobile phase composition.", "output": {"entities": {}}, "schema": []}
{"input": "In general, however, this study provided little evidence of any effect of supplementation to athletic performance for athletes consuming the dietary RDIs.", "output": {"entities": {}}, "schema": []}
{"input": "In 7 of 9 cases, the enhancer is fused to the c-myc bearing sequences of chromosome 8.", "output": {"entities": {"gene": [{"text": "c-myc bearing sequences", "start": 46, "end": 69}]}}, "schema": []}
{"input": "These components both had a median R2 of 0. 84, compared to median R2s ranging from 0. 37 to 0. 83 for five commonly used ad hoc EEG components.", "output": {"entities": {}}, "schema": []}
{"input": "The obtained results were compared with control group (10 female volunteers).", "output": {"entities": {}}, "schema": []}
{"input": "100 years of dentistry at the Friedrich Schiller University in Jena", "output": {"entities": {}}, "schema": []}
{"input": "The target contained between positions-403 and-125 acts independently of orientation, in different cell types and species, and in the context of a heterologous promoter.", "output": {"entities": {}}, "schema": []}
{"input": "Synergistic transactivation of the BMRF1 promoter by the Z/c-myb combination appears to involve direct binding by the Z protein but not the c-myb protein.", "output": {"entities": {"gene": [{"text": "BMRF1 promoter", "start": 35, "end": 49}, {"text": "Z", "start": 57, "end": 58}, {"text": "c-myb", "start": 59, "end": 64}, {"text": "Z protein", "start": 118, "end": 127}, {"text": "c-myb protein", "start": 140, "end": 153}]}}, "schema": []}
{"input": "The UCR core sequence, CGCCATTTT, binds a ubiquitous nuclear factor and mediates negative regulation of MuLV promoter activity.", "output": {"entities": {}}, "schema": []}
{"input": "These studies show that UCRBP binds to various target motifs that are distinct from the UCR motif: the adeno-associated virus P5 promoter and elements in the immunoglobulin light-and heavy-chain genes, as well as elements in ribosomal protein genes.", "output": {"entities": {"gene": [{"text": "UCRBP", "start": 24, "end": 29}, {"text": "adeno-associated virus P5 promoter", "start": 103, "end": 137}, {"text": "immunoglobulin light-and heavy-chain", "start": 158, "end": 194}, {"text": "ribosomal protein genes", "start": 225, "end": 248}]}}, "schema": []}
{"input": "The cellular sequences 5' to the viral integration site exhibited 85 to 97% identity to several sequences belonging to the mouse L1 family of long interspersed repetitive sequences.", "output": {"entities": {"gene": [{"text": "mouse L1 family", "start": 123, "end": 138}]}}, "schema": []}
{"input": "These results indicate that both N-and C-terminal mutations are required to inhibit transrepression by FBR protein and that multiple structural mutations accompanied by posttranslational protein modification alter gene regulation by FBR protein.", "output": {"entities": {"gene": [{"text": "FBR protein", "start": 103, "end": 114}, {"text": "FBR protein", "start": 233, "end": 244}]}}, "schema": []}
{"input": "The JS78 mutation changes Gln243 in gp0. 7 to an amber codon, which explains the production of the truncated, 30-kDa gp0. 7-related polypeptide, and implicates the 11-kDa C-terminal domain in host transcription shut-off.", "output": {"entities": {"gene": [{"text": "30-kDa gp0. 7-related polypeptide", "start": 110, "end": 143}]}}, "schema": []}
{"input": "The predicted receptor structure includes a cysteine-rich extracellular domain, a single hydrophobic transmembrane domain, and a predicted cytoplasmic serine/threonine kinase domain.", "output": {"entities": {"gene": [{"text": "cytoplasmic serine/threonine kinase domain", "start": 139, "end": 181}]}}, "schema": []}
{"input": "Drosophila UbcD1 encodes a highly conserved ubiquitin-conjugating enzyme involved in selective protein degradation.", "output": {"entities": {"gene": [{"text": "Drosophila UbcD1", "start": 0, "end": 16}, {"text": "ubiquitin", "start": 44, "end": 53}]}}, "schema": []}
{"input": "Analysis of the entire 16. 7-kb mt genome determined that a MDP1 mediates cleavage of chick mtDNA in vitro at three H-and two L-strand sequence-specific target sites located within a 90-bp A + T-rich genomic tract, theoretically capable of forming stable secondary structures, approximately 200 bases upstream from the H-strand origin (OH) of replication.", "output": {"entities": {"gene": [{"text": "MDP1", "start": 60, "end": 64}]}}, "schema": []}
{"input": "The goal of the present study was to determine the feasibility of retrovirus mediated expression of rp47phox in the HL60 and U937 human hematopoietic cell lines, and in an Epstein-Barr virus transformed B-lymphocyte cell line (EBV-BCL) derived from a p47phox-deficient CGD patient.", "output": {"entities": {"gene": [{"text": "rp47phox", "start": 100, "end": 108}, {"text": "p47phox", "start": 251, "end": 258}]}}, "schema": []}
{"input": "A rather similar pattern of results was obtained with respect to LMP2B mRNA expression, such transcripts being detectable only in a subset of tumors, and then at apparently low levels.", "output": {"entities": {"gene": [{"text": "LMP2B mRNA", "start": 65, "end": 75}]}}, "schema": []}
{"input": "Analysis of nucleotide sequence of the rightmost 43 kbp of herpesvirus saimiri (HVS) L-DNA: general conservation of genetic organization between HVS and Epstein-Barr virus.", "output": {"entities": {}}, "schema": []}
{"input": "Treatment with MK-801 induced a burst suppression in the EEG and a transient drop (11. 4 +/-6. 5 mm Hg) in the mean arterial pressure.", "output": {"entities": {}}, "schema": []}
{"input": "Myogenic differentiation can be inhibited by the adenovirus E1a protein in the rat L6 muscle cell line.", "output": {"entities": {"gene": [{"text": "E1a protein", "start": 60, "end": 71}]}}, "schema": []}
{"input": "Acad.", "output": {"entities": {}}, "schema": []}
{"input": "Both in vitro-synthesized S2 protein and synthetic peptides corresponding to S2 are shown to react positively with sera obtained from EIAV-infected horses, providing the first direct evidence of expression of this protein in infected animals.", "output": {"entities": {"gene": [{"text": "S2 protein", "start": 26, "end": 36}, {"text": "S2", "start": 77, "end": 79}]}}, "schema": []}
{"input": "Many canonical TATA sequences are present upstream from these VZV transcriptional start sites but, apparently, are not used.", "output": {"entities": {}}, "schema": []}
{"input": "The ORF 4 gene was minimally active, whereas the ORF 62 gene gave twofold induction; both genes, acting together, gave fivefold induction.", "output": {"entities": {}}, "schema": []}
{"input": "Interestingly, the IR5 ORF of EHV-1 possesses a sequence of 13 amino acids (CAYWCCLGHAFAC) that is a perfect match to the consensus zinc finger motif (C-X2-4-C-X2-15-C/H-X2-4-C/H).", "output": {"entities": {"gene": [{"text": "IR5 ORF", "start": 19, "end": 26}]}}, "schema": []}
{"input": "The DNA sequence of the sulfate activation locus from Escherichia coli K-12 has been determined.", "output": {"entities": {"gene": [{"text": "sulfate activation locus", "start": 24, "end": 48}]}}, "schema": []}
{"input": "Plasma membranes of cultured cells contain high affinity receptors for high density lipoprotein (HDL) that appear to mediate removal of excess intracellular cholesterol.", "output": {"entities": {"gene": [{"text": "high density lipoprotein", "start": 71, "end": 95}, {"text": "HDL", "start": 97, "end": 100}]}}, "schema": []}
{"input": "After the first 28 patients vincristine was replaced by teniposide (VM-26) due to neurotoxicity.", "output": {"entities": {}}, "schema": []}
{"input": "These results indicate that an internal short element located at the very 5' terminal of L1 sequence and the nuclear factor binding to the element play a crucial role in the transcription of human L1.", "output": {"entities": {"gene": [{"text": "L1 sequence", "start": 89, "end": 100}, {"text": "human L1", "start": 191, "end": 199}]}}, "schema": []}
{"input": "Tumor cells were focally immunoreactive for neuron-specific enolase, insulin, glucagon and VIP.", "output": {"entities": {"gene": [{"text": "neuron-specific enolase", "start": 44, "end": 67}, {"text": "insulin", "start": 69, "end": 76}, {"text": "glucagon", "start": 78, "end": 86}, {"text": "VIP", "start": 91, "end": 94}]}}, "schema": []}
{"input": "A recombinant with a 5' end from src and a 3' end from ros, called SRC x ROS, transformed chicken embryo fibroblasts (CEF) to a spindle shape morphology, mimicking that of UR2.", "output": {"entities": {"gene": [{"text": "src", "start": 33, "end": 36}, {"text": "ros", "start": 55, "end": 58}, {"text": "SRC", "start": 67, "end": 70}, {"text": "ROS", "start": 73, "end": 76}, {"text": "UR2", "start": 172, "end": 175}]}}, "schema": []}
{"input": "ROS x SRC (R) contains a 16-amino-acid deletion that includes the 3' half of the transmembrane domain of ros.", "output": {"entities": {"gene": [{"text": "ROS", "start": 0, "end": 3}, {"text": "SRC", "start": 6, "end": 9}, {"text": "R", "start": 11, "end": 12}, {"text": "ros", "start": 105, "end": 108}]}}, "schema": []}
{"input": "To define the number and nature of the E6 and E7 gene products expressed in BPV-1-transformed cells, we performed immunoprecipitation experiments with antisera raised to bacterially expressed BPV-1 E6 and E7 fusion proteins.", "output": {"entities": {"gene": [{"text": "E6", "start": 39, "end": 41}, {"text": "E7 gene", "start": 46, "end": 53}, {"text": "BPV-1 E6", "start": 192, "end": 200}, {"text": "E7 fusion proteins", "start": 205, "end": 223}]}}, "schema": []}
{"input": "Transient transfection assays showed that site A is necessary and sufficient for RXR alpha-mediated transactivation of the apoAI gene basal promoter in human hepatoma HepG2 cells in the presence of RA and that this transactivation is abolished by increasing amounts of cotransfected ARP-1.", "output": {"entities": {"gene": [{"text": "RXR alpha", "start": 81, "end": 90}, {"text": "apoAI gene basal promoter", "start": 123, "end": 148}, {"text": "ARP-1", "start": 283, "end": 288}]}}, "schema": []}
{"input": "A third prominent component of apparent molecular mass 16 kDa displayed several properties, including ability to bind 45Ca2 +, that are characteristic of the regulatory (B) subunit of mammalian calcineurin and was recognized by an antiserum raised against bovine calcineurin.", "output": {"entities": {"gene": [{"text": "mammalian calcineurin", "start": 184, "end": 205}, {"text": "bovine calcineurin", "start": 256, "end": 274}]}}, "schema": []}
{"input": "As was observed previously for MATa cna1 cna2 double mutants, MATa cnb1 mutants were defective in their ability to recover from alpha-factor-induced growth arrest.", "output": {"entities": {"gene": [{"text": "MATa cna1 cna2", "start": 31, "end": 45}, {"text": "MATa cnb1 mutants", "start": 62, "end": 79}, {"text": "alpha-factor", "start": 128, "end": 140}]}}, "schema": []}
{"input": "Antibodies against this purified protein localize RIM1 to mitochondria.", "output": {"entities": {"gene": [{"text": "RIM1", "start": 50, "end": 54}]}}, "schema": []}
{"input": "METHODS: IgG antibodies vs HHV-6 (anti-HHV-6-IgG) were determined by indirect immunofluorescence in 100 IVDA (29 seronegative and 71 seropositive for HIV-1 of which 45 were in stage II and 26 in IV-C1 of CDC) as well as in 100 healthy subjects of a similar age (control group).", "output": {"entities": {"gene": [{"text": "IgG antibodies", "start": 9, "end": 23}, {"text": "anti-HHV-6-IgG", "start": 34, "end": 48}]}}, "schema": []}
{"input": "A position-independent activation domain which contained conserved regions II and III was identified at the carboxyl terminus of the HNF-3 beta protein (amino acids 361 to 458).", "output": {"entities": {"gene": [{"text": "HNF-3 beta protein", "start": 133, "end": 151}]}}, "schema": []}
{"input": "HNF-3 beta amino-terminal sequences defined by conserved region IV also contributed to transactivation, but region IV activity required the participation of the region II-III domain.", "output": {"entities": {"gene": [{"text": "HNF-3 beta amino-terminal sequences", "start": 0, "end": 35}]}}, "schema": []}
{"input": "Possible roles of RAD5 putative ATPase/DNA helicase activity in DNA repair and in the maintenance of wild-type rates of instability of simple repetitive sequences are discussed.", "output": {"entities": {"gene": [{"text": "RAD5", "start": 18, "end": 22}, {"text": "ATPase", "start": 32, "end": 38}, {"text": "DNA helicase", "start": 39, "end": 51}]}}, "schema": []}
{"input": "Susceptibilities of 540 anaerobic gram-negative bacilli to amoxicillin, amoxicillin-BRL 42715, amoxicillin-clavulanate, temafloxacin, and clindamycin.", "output": {"entities": {}}, "schema": []}
{"input": "Nocodazole arrest of DU249 cells was exploited for the detection of an M-phase-activated MBP kinase that was resolved from p41 MAP kinase by phenyl-Superose chromatography.", "output": {"entities": {"gene": [{"text": "MBP kinase", "start": 89, "end": 99}, {"text": "p41 MAP kinase", "start": 123, "end": 137}]}}, "schema": []}
{"input": "The hit1-1 mutation caused a defect in synthesis of a 74-kD heat shock protein.", "output": {"entities": {"gene": [{"text": "hit1-1", "start": 4, "end": 10}, {"text": "74-kD heat shock protein", "start": 54, "end": 78}]}}, "schema": []}
{"input": "The 319 base pair region immediately upstream of the CAP site is characterized by the lack of a proximal TATA box and the presence of sequences similar to GC boxes, CACCC boxes, CCAAT boxes, activator protein 2 (Ap-2) sites, partial glucocorticoid response elements (GREs), and partial cyclic AMP response elements (CREs).", "output": {"entities": {"gene": [{"text": "activator protein 2", "start": 191, "end": 210}, {"text": "Ap-2", "start": 212, "end": 216}]}}, "schema": []}
{"input": "In rats anaesthetized with +-chloralose the changes in extracellular pH and K + in spinal cord dorsal horn were studied using pH and K + ion-selective electrodes.", "output": {"entities": {}}, "schema": []}
{"input": "Replication of bovine papillomavirus-1 (BPV-1) DNA requires two viral gene products, the E1 protein and the full-length E2 protein.", "output": {"entities": {"gene": [{"text": "E1 protein", "start": 89, "end": 99}, {"text": "full-length E2 protein", "start": 108, "end": 130}]}}, "schema": []}
{"input": "Insertional inactivation of sms led to increased sensitivity to the alkylating agent methylmethane sulfonate, but not to a requirement for serine or other metabolites.", "output": {"entities": {"gene": [{"text": "sms", "start": 28, "end": 31}]}}, "schema": []}
{"input": "These findings suggest that the MAP kinase activator/MAP kinase system may be the downstream components of ras signal transduction pathways.", "output": {"entities": {"gene": [{"text": "MAP kinase activator", "start": 32, "end": 52}, {"text": "MAP kinase", "start": 53, "end": 63}, {"text": "ras", "start": 107, "end": 110}]}}, "schema": []}
{"input": "NSCL-1 is expressed in a larger number of these cell lines.", "output": {"entities": {"gene": [{"text": "NSCL-1", "start": 0, "end": 6}]}}, "schema": []}
{"input": "Labile LTR-binding proteins appear to be essential for c-myc hyperexpression, since both LTR-enhanced transcription and the activities of LTR-binding proteins are specifically decreased after inhibition of protein synthesis (A.", "output": {"entities": {"gene": [{"text": "LTR-binding proteins", "start": 7, "end": 27}, {"text": "c-myc", "start": 55, "end": 60}, {"text": "LTR-binding proteins", "start": 138, "end": 158}]}}, "schema": []}
{"input": "Ruddell, M.", "output": {"entities": {}}, "schema": []}
{"input": "A single MEF-2 site is a major positive regulatory element required for transcription of the muscle-specific subunit of the human phosphoglycerate mutase gene in skeletal and cardiac muscle cells.", "output": {"entities": {"gene": [{"text": "MEF-2 site", "start": 9, "end": 19}, {"text": "human phosphoglycerate mutase gene", "start": 124, "end": 158}]}}, "schema": []}
{"input": "Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs.", "output": {"entities": {"gene": [{"text": "MHC class II molecules", "start": 46, "end": 68}]}}, "schema": []}
{"input": "Although the E-box consensus is minimally defined as CANNTG, the adjacent nucleotides of functional E-boxes are variable for genes regulated by the bHLH proteins.", "output": {"entities": {"gene": [{"text": "bHLH proteins", "start": 148, "end": 161}]}}, "schema": []}
{"input": "Intermediate levels of gene activity were observed for TnI enhancers containing E-boxes derived from the MCK left E-box site or from the Ig kappa E2 E-box.", "output": {"entities": {"gene": [{"text": "TnI enhancers", "start": 55, "end": 68}, {"text": "MCK left E-box site", "start": 105, "end": 124}, {"text": "Ig kappa E2 E-box", "start": 137, "end": 154}]}}, "schema": []}
{"input": "T-cell receptor beta (TCR beta) gene rearrangements occur in a third of early B-cell acute lymphoblastic leukemias (ALLs).", "output": {"entities": {"gene": [{"text": "T-cell receptor beta", "start": 0, "end": 20}, {"text": "TCR beta", "start": 22, "end": 30}]}}, "schema": []}
{"input": "The CANNTG motifs were found to bind MyoD and myogenin fusion proteins and to interact with proteins in nuclear extracts from cultured myotubes.", "output": {"entities": {"gene": [{"text": "MyoD", "start": 37, "end": 41}, {"text": "myogenin fusion proteins", "start": 46, "end": 70}]}}, "schema": []}
{"input": "Peripheral polyneuropathy associated with multiple myeloma.", "output": {"entities": {}}, "schema": []}
{"input": "We have cloned and sequenced COX12, the nuclear gene for subunit VIb of Saccharomyces cerevisiae cytochrome c oxidase.", "output": {"entities": {"gene": [{"text": "COX12", "start": 29, "end": 34}, {"text": "subunit VIb", "start": 57, "end": 68}, {"text": "Saccharomyces cerevisiae cytochrome c oxidase", "start": 72, "end": 117}]}}, "schema": []}
{"input": "The structure of the calcineurin A gene was determined by comparison of the genomic and cDNA sequences.", "output": {"entities": {"gene": [{"text": "calcineurin A gene", "start": 21, "end": 39}]}}, "schema": []}
{"input": "The basal promoter elements of murine cytochrome c oxidase subunit IV gene consist of tandemly duplicated ets motifs that bind to GABP-related transcription factors.", "output": {"entities": {"gene": [{"text": "murine cytochrome c oxidase subunit IV gene", "start": 31, "end": 74}, {"text": "ets", "start": 106, "end": 109}, {"text": "GABP-related transcription factors", "start": 130, "end": 164}]}}, "schema": []}
{"input": "Lastly, there are multiple instances in which short oligonucleotide direct repeats flank a region absent from either variola or vaccinia virus.", "output": {"entities": {}}, "schema": []}
{"input": "Here we show that short synthetic peptides containing the pRB-binding sequences of E1A are sufficient for interaction with p107, cyclin A, and p130.", "output": {"entities": {"gene": [{"text": "pRB-binding sequences", "start": 58, "end": 79}, {"text": "E1A", "start": 83, "end": 86}, {"text": "p107", "start": 123, "end": 127}, {"text": "cyclin A", "start": 129, "end": 137}, {"text": "p130", "start": 143, "end": 147}]}}, "schema": []}
{"input": "These mutants grow normally in 3T6 mouse fibroblast cells, and they do not complement the wild-type virus in coinfection experiments of C2 myoblasts.", "output": {"entities": {}}, "schema": []}
{"input": "The MICs of this compound against 90% of these organisms, except for methicillin-resistant S. aureus, ranged from less than or equal to 0. 006 to 3. 13 micrograms/ml.", "output": {"entities": {}}, "schema": []}
{"input": "The minimal promoter of the RII beta gene was composed of two adjacent functional elements.", "output": {"entities": {"gene": [{"text": "RII beta gene", "start": 28, "end": 41}]}}, "schema": []}
{"input": "Mapping the cAMP receptor protein contact site on the alpha subunit of Escherichia coli RNA polymerase.", "output": {"entities": {"gene": [{"text": "cAMP receptor protein contact site", "start": 12, "end": 46}, {"text": "Escherichia coli RNA polymerase", "start": 71, "end": 102}]}}, "schema": []}
{"input": "Here we show that epidermal growth factor or platelet-derived growth factor stimulation of intact human or murine cells leads to phosphorylation of Nck protein on tyrosine, serine, and threonine residues.", "output": {"entities": {"gene": [{"text": "epidermal growth factor", "start": 18, "end": 41}, {"text": "platelet-derived growth factor", "start": 45, "end": 75}, {"text": "Nck protein", "start": 148, "end": 159}]}}, "schema": []}
{"input": "A major mechanism whereby steroid hydroxylase gene transcription is regulated in the adrenal cortex requires the pituitary peptide hormone, ACTH, which acts via cAMP.", "output": {"entities": {"gene": [{"text": "steroid hydroxylase gene", "start": 26, "end": 50}, {"text": "ACTH", "start": 140, "end": 144}]}}, "schema": []}
{"input": "A combination of comparative sequence analysis and thermodynamic methods reveals the conservation of tertiary structure elements in the 5' untranslated region (UTR) of human enteroviruses and rhinoviruses.", "output": {"entities": {}}, "schema": []}
{"input": "Km and Vmax for two substrates, src-related peptide and poly (Glu, Tyr) (4: 1), were 2. 4 mM and 2. 5 mumol min-1 mg-1 and 0. 26 mM and 1. 2 mumol min-1 mg-1, respectively.", "output": {"entities": {"gene": [{"text": "src-related peptide", "start": 32, "end": 51}]}}, "schema": []}
{"input": "Strategies for blood screening for the hepatitis C virus and for the human immunodeficiency virus in high risk groups.", "output": {"entities": {}}, "schema": []}
{"input": "Comparison of data obtained with the results of chronic treatment with the opioid antagonist permits to conclude that the chronic blockade increases the fatiguability to a great extent than chronic activation of opioid system.", "output": {"entities": {}}, "schema": []}
{"input": "Laboratory studies using Ca45 labeled teeth and biologically stained teeth confirmed that the dentifrice did not decalcify enamel or bleach teeth.", "output": {"entities": {}}, "schema": []}
{"input": "Structure and expression of a gene from Arabidopsis thaliana encoding a protein related to SNF1 protein kinase.", "output": {"entities": {"gene": [{"text": "SNF1", "start": 91, "end": 95}]}}, "schema": []}
{"input": "We have cloned and characterized a 55-kb region of DNA surrounding HRAS1.", "output": {"entities": {"gene": [{"text": "HRAS1", "start": 67, "end": 72}]}}, "schema": []}
{"input": "The ORF1 protein was found to be highly homologous to the putative potexvirus RNA replicases; ORF2,-3,-5 and-6 proteins also have analogues among the potex-and/or carlavirus-encoded proteins.", "output": {"entities": {"gene": [{"text": "potexvirus RNA replicases", "start": 67, "end": 92}]}}, "schema": []}
{"input": "A total of 281 patients were divided into groups according to their clinical diagnosis and were examined using capnography, spirometry and blood-gas analysis.", "output": {"entities": {}}, "schema": []}
{"input": "The relationships between the partial pressures of O2 and CO2 as well as between their gradients, become stronger with the increase of the ventilation-perfusion ratio.", "output": {"entities": {}}, "schema": []}
{"input": "No significant correlations of peak VO2 were observed between the 3 tests.", "output": {"entities": {}}, "schema": []}
{"input": "An RNA-binding protein gene (rbp1) from Drosophila melanogaster, encoding an RNA recognition motif and an Arg-Ser rich (RS) domain, has been characterized.", "output": {"entities": {"gene": [{"text": "RNA-binding protein gene", "start": 3, "end": 27}, {"text": "rbp1", "start": 29, "end": 33}]}}, "schema": []}
{"input": "A comparative study of the total protein profiles of wild-type S. entomophila UC9 and mutant UC21 revealed that the mutant lacked an approximately 44-kDa protein and overexpressed an approximately 20-kDa protein.", "output": {"entities": {}}, "schema": []}
{"input": "Characterization of the regulon controlled by the leucine-responsive regulatory protein in Escherichia coli.", "output": {"entities": {"gene": [{"text": "leucine-responsive regulatory protein", "start": 50, "end": 87}]}}, "schema": []}
{"input": "Mapping of the mouse ornithine decarboxylase-related sequence family.", "output": {"entities": {"gene": [{"text": "mouse ornithine decarboxylase-related sequence family", "start": 15, "end": 68}]}}, "schema": []}
{"input": "This mutation also results in markedly decreased levels of CAD mRNA and protein in the mutant.", "output": {"entities": {"gene": [{"text": "CAD mRNA", "start": 59, "end": 67}]}}, "schema": []}
{"input": "Mutational studies revealed that it was the homeodomain binding site II sequence that was required for this regulation.", "output": {"entities": {"gene": [{"text": "homeodomain binding site II sequence", "start": 44, "end": 80}]}}, "schema": []}
{"input": "Thus, the pol alpha-primase complex appears to act processively for only a short distance.", "output": {"entities": {"gene": [{"text": "pol alpha", "start": 10, "end": 19}, {"text": "primase", "start": 20, "end": 27}]}}, "schema": []}
{"input": "Interestingly, the positions of these introns have been conserved in comparison with the genes of two other transglutaminase-like activities described in the literature, but the TGM1 gene is by far the smallest characterized to date because its introns are relatively smaller.", "output": {"entities": {"gene": [{"text": "TGM1 gene", "start": 178, "end": 187}]}}, "schema": []}
{"input": "In a retrospective analysis of data from 35 cases with malignant lymphoma from a cohort of 2017 HIV-infected patients, the stage of HIV-disease, the CD4 counts at the time of diagnosis, and the use of antineoplastic agents or radiotherapy were correlated with outcome.", "output": {"entities": {"gene": [{"text": "CD4", "start": 149, "end": 152}]}}, "schema": []}
{"input": "1.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of dioxins on thyroid function in newborn babies.", "output": {"entities": {}}, "schema": []}
{"input": "cDNA clones encoding Arabidopsis thaliana and Zea mays mitochondrial chaperonin HSP60 and gene expression during seed germination and heat shock.", "output": {"entities": {"gene": [{"text": "Zea mays mitochondrial chaperonin HSP60", "start": 46, "end": 85}]}}, "schema": []}
{"input": "The single site of glycosylation is located near the C-terminus in the N-glycosylation sequon-Asn-Cys-Ser-in which Cys forms part of a disulphide bridge.", "output": {"entities": {}}, "schema": []}
{"input": "The pulmonary toxic events induced by acute nitrogen dioxide (NO) 2 exposure were studied in the rat to develop an inhalation model to investigate therapeutic measures.", "output": {"entities": {}}, "schema": []}
{"input": "The pulmonary effects observed, became more pronounced with increasing NO2 concentrations (0, 25, 75, 125, 175 or 200 ppm, 1 ppm NO2 = 1. 88 mg m-3 NO2) and exposure times (5, 10, 20 or 30 min).", "output": {"entities": {}}, "schema": []}
{"input": "Interaction of H-2Eb with an IAP retrotransposon in the A20/2J B cell lymphoma.", "output": {"entities": {"gene": [{"text": "H-2Eb", "start": 15, "end": 20}, {"text": "IAP retrotransposon", "start": 29, "end": 48}]}}, "schema": []}
{"input": "Gestational trophoblastic diseases: recent advances in the understanding of cytogenetics, histopathology, and natural history.", "output": {"entities": {}}, "schema": []}
{"input": "With the exception of mutants that remove the membrane anchor domain, all of the mutant glycoproteins retained the ability to cause fusion of CD4-bearing cells.", "output": {"entities": {"gene": [{"text": "CD4", "start": 142, "end": 145}]}}, "schema": []}
{"input": "The subunit protein of curli was highly homologous at its amino terminus to SEF-17, the subunit protein of thin, aggregative fimbriae of Salmonella enteritidis 27655 strain 3b, suggesting that these fibres form a novel class of surface organelles on enterobacteria.", "output": {"entities": {"gene": [{"text": "curli", "start": 23, "end": 28}, {"text": "SEF-17", "start": 76, "end": 82}]}}, "schema": []}
{"input": "Substitution of the DR1 beta chain with H-2E beta k led to a dramatic loss of recognition; alpha chain substitution had a less marked effect.", "output": {"entities": {"gene": [{"text": "DR1 beta chain", "start": 20, "end": 34}, {"text": "H-2E beta k", "start": 40, "end": 51}]}}, "schema": []}
{"input": "This negative regulatory pathway may be important for determining cell fate or maintaining an inducible state in the ventroposterior region of the embryo.", "output": {"entities": {}}, "schema": []}
{"input": "The distal portion of the rat insulin I gene 5'-flanking DNA contains two sequence elements, the Far and FLAT elements, that can function in combination, but not separately, as a beta-cell-specific transcriptional enhancer.", "output": {"entities": {"gene": [{"text": "rat insulin I gene 5'-flanking DNA", "start": 26, "end": 60}]}}, "schema": []}
{"input": "The deduced amino acid sequence exhibited 98% identity to the human cellular transglutaminase sequence.", "output": {"entities": {}}, "schema": []}
{"input": "Repeated efforts to isolate recombinant baculoviruses containing a wild-type kinase failed, whereas recombinants expressing a nonfunctional kinase with a catalytic domain II mutation were readily isolated.", "output": {"entities": {}}, "schema": []}
{"input": "Finally, we determined that the P68 amino terminus was both necessary and sufficient for binding dsRNA as we were able to transfer dsRNA-binding properties to a reporter gene product previously unable to bind RNA.", "output": {"entities": {"gene": [{"text": "P68", "start": 32, "end": 35}]}}, "schema": []}
{"input": "From August 1989 to October 1990, 83 pregnant Chinese women were the subjects for measuring the levels of plasma functional antithrombin III (AT III) activity.", "output": {"entities": {"gene": [{"text": "antithrombin III", "start": 124, "end": 140}, {"text": "AT III", "start": 142, "end": 148}]}}, "schema": []}
{"input": "Visual acuity may be decreased by transient changes in refractive error caused by sulfonamides, the antifungal agent metronidazole, thiazide diuretics, and carbonic anhydrase inhibitors.", "output": {"entities": {"gene": [{"text": "carbonic anhydrase", "start": 156, "end": 174}]}}, "schema": []}
{"input": "Currents aspects of H2 receptor antagonists in the treatment of ulcers", "output": {"entities": {"gene": [{"text": "H2 receptor", "start": 20, "end": 31}]}}, "schema": []}
{"input": "In addition, a 21-mer subrepeat structure is also present in each unit.", "output": {"entities": {}}, "schema": []}
{"input": "Sequencing revealed one large open reading frame encoding a 39-kDa protein.", "output": {"entities": {}}, "schema": []}
{"input": "These sites are also potential keratan sulfate attachment sites.", "output": {"entities": {}}, "schema": []}
{"input": "We propose that plasmids of the pLS1 family (pE194, pADB201, and pLB4) share functional and structural characteristics for the regulation of their copy numbers.", "output": {"entities": {}}, "schema": []}
{"input": "Perturbation of dNTP pools also affected the frameshift fidelity of the replicative yeast DNA polymerase alpha.", "output": {"entities": {"gene": [{"text": "yeast DNA polymerase alpha", "start": 84, "end": 110}]}}, "schema": []}
{"input": "Differential expression of the \" B \" subunit of the vacuolar H (+)-ATPase in bovine tissues.", "output": {"entities": {"gene": [{"text": "vacuolar H (+)-ATPase", "start": 52, "end": 73}]}}, "schema": []}
{"input": "In addition, the hGCSFR gene was chromosomally localized by Southern blot analysis of its segregation pattern in a panel of rodent-human hybrid DNAs using the radiolabeled cDNA probe.", "output": {"entities": {"gene": [{"text": "hGCSFR gene", "start": 17, "end": 28}]}}, "schema": []}
{"input": "We have isolated and characterised a differentially-regulated gene family in the protozoan parasite Leishmania major.", "output": {"entities": {}}, "schema": []}
{"input": "At some sites,% T is greatly increased by Cl-concentrations up to 1 M, while at other sites% T is reduced or unaffected by these conditions.", "output": {"entities": {}}, "schema": []}
{"input": "Necrosis appears 6 h after TA infusion, being 5. 77% in extent after 12 h, 14. 9% after 24 h and animals die with an area of 29. 5% necrosis.", "output": {"entities": {}}, "schema": []}
{"input": "In summary, the segments of C3 represented by amino acid residues 1082-1118, 1117-1155, 1234-1294 and 1312-1404 accommodate C3 (D) epitopes that are expressed by erythrocyte-bound C3 fragments, but not by the corresponding fluid-phase fragment, whereas the segments spanning residues 973-1026 and 1477-1510 contain C3 (D) epitopes that are exposed exclusively in denatured C3 and therefore hidden in physiological fragments of the protein.", "output": {"entities": {"gene": [{"text": "C3", "start": 28, "end": 30}, {"text": "C3 (D) epitopes", "start": 124, "end": 139}, {"text": "C3 fragments", "start": 180, "end": 192}, {"text": "C3 (D) epitopes", "start": 315, "end": 330}, {"text": "C3", "start": 373, "end": 375}]}}, "schema": []}
{"input": "These exons, further identified as exons 9, 10, and 11, together encode the 37 amino acid residues present in alpha s1-casein variant A but missing in variant F.", "output": {"entities": {"gene": [{"text": "alpha s1-casein variant A", "start": 110, "end": 135}]}}, "schema": []}
{"input": "We also report here the complete structural organization of the goat alpha s1-casein transcription unit, deduced from polymerase chain reaction experiments.", "output": {"entities": {"gene": [{"text": "goat alpha s1-casein transcription unit", "start": 64, "end": 103}]}}, "schema": []}
{"input": "Homodimers of the three proteins specifically recognize the G-box motif, with GBF1 and GBF3 binding symmetrically to this palindromic sequence.", "output": {"entities": {"gene": [{"text": "GBF1", "start": 78, "end": 82}, {"text": "GBF3", "start": 87, "end": 91}]}}, "schema": []}
{"input": "The hydrophobicity plot of NHE-3 is very similar to that of NHE-1 and NHE-2.", "output": {"entities": {"gene": [{"text": "NHE-3", "start": 27, "end": 32}, {"text": "NHE-1", "start": 60, "end": 65}, {"text": "NHE-2", "start": 70, "end": 75}]}}, "schema": []}
{"input": "The initial translation protein encoded by the cDNA is 53, 932 kDa and possesses a hydrophilic amino acid composition with glutamic acid comprising 22% of the total amino acid residues.", "output": {"entities": {}}, "schema": []}
{"input": "Each group received 15 ml/kg of either 6% pentafraction, 6% pentastarch, or plasma followed two hours later by 1. 5 micrograms/kg/0. 5 hr E.", "output": {"entities": {}}, "schema": []}
{"input": "Genetic and biochemical evidence suggests that v-Crk can induce transformation of chicken embryo fibroblasts by influencing the activity of cellular proteins involved in growth regulation.", "output": {"entities": {"gene": [{"text": "v-Crk", "start": 47, "end": 52}]}}, "schema": []}
{"input": "We have constructed, using synthetic DNA oligonucleotides, a U14 snRNA gene which has been positioned behind a T7 RNA polymerase promoter site and then inserted into a plasmid.", "output": {"entities": {"gene": [{"text": "U14 snRNA gene", "start": 61, "end": 75}, {"text": "T7 RNA polymerase promoter site", "start": 111, "end": 142}]}}, "schema": []}
{"input": "The carcinoma was restricted within the epithelium in one, the mucosal layer in five, and the submucosal layer in two.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, C/EBP beta and C/EBP gamma readily heterodimerize with each other as well as with C/EBP alpha.", "output": {"entities": {"gene": [{"text": "C/EBP beta", "start": 13, "end": 23}, {"text": "C/EBP gamma", "start": 28, "end": 39}, {"text": "C/EBP alpha", "start": 95, "end": 106}]}}, "schema": []}
{"input": "In contrast, tobacco GS-2 is composed of subunits of identical size in all organs examined.", "output": {"entities": {"gene": [{"text": "tobacco GS-2", "start": 13, "end": 25}]}}, "schema": []}
{"input": "Between acoR and acoXABC, two different types of sequences with dual rotational symmetry [CAC-(N11 to N18)-GTG and TGT-(N10 to N14)-ACA] were found; these sequences are similar to NtrC and NifA upstream activator sequences, respectively.", "output": {"entities": {"gene": [{"text": "acoR", "start": 8, "end": 12}, {"text": "acoXABC", "start": 17, "end": 24}, {"text": "NtrC", "start": 180, "end": 184}, {"text": "NifA upstream activator sequences", "start": 189, "end": 222}]}}, "schema": []}
{"input": "Although the effects of the calcium supplement or calcium antagonist alone were significant, such hypotensive responses were not optimal or predictable or clearly dose-dependent.", "output": {"entities": {}}, "schema": []}
{"input": "C., Sun, J., Hsu, M.-Y., Vallejo-Ramirez, J., Inouye, S., and Inouye, M.", "output": {"entities": {}}, "schema": []}
{"input": "Surprisingly, the full-deletion mutant showed a strong block in virus release, suggesting that NC is involved in virus assembly.", "output": {"entities": {"gene": [{"text": "NC", "start": 95, "end": 97}]}}, "schema": []}
{"input": "Furthermore it was suggested that FK506 plasma levels were concerned with the appearance of side effect.", "output": {"entities": {}}, "schema": []}
{"input": "Thirty percent of patients were tapered off all steroids, and the average steroid dose in the group who received steroids was 8. 6 mg of prednisone per day.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, cibenzoline is an effective antiarrhythmic agent with a favourable pharmacokinetic profile that may be considered with other class I drugs in patients requiring therapy for high risk arrhythmias.", "output": {"entities": {}}, "schema": []}
{"input": "T antigen contains four H-2Db-restricted cytotoxic T lymphocyte (CTL) recognition epitopes that are targets for CTL clones Y-1, Y-2, Y-3, and Y-5.", "output": {"entities": {"gene": [{"text": "T antigen", "start": 0, "end": 9}]}}, "schema": []}
{"input": "The method requires a reversed-phase column and a paired-ion technique to separate docusate sodium from other components.", "output": {"entities": {}}, "schema": []}
{"input": "Here we demonstrate that the protein product of the ref-1 gene stimulates the DNA binding activity of Fos-Jun heterodimers, Jun-Jun homodimers and Hela cell AP-1 proteins as well as that of several other transcription factors including NF-kappa B, Myb and members of the ATF/CREB family.", "output": {"entities": {"gene": [{"text": "ref-1 gene", "start": 52, "end": 62}, {"text": "Fos", "start": 102, "end": 105}, {"text": "Jun", "start": 106, "end": 109}, {"text": "Jun", "start": 124, "end": 127}, {"text": "Jun", "start": 128, "end": 131}, {"text": "AP-1 proteins", "start": 157, "end": 170}, {"text": "NF-kappa B", "start": 236, "end": 246}, {"text": "Myb", "start": 248, "end": 251}, {"text": "ATF", "start": 271, "end": 274}, {"text": "CREB", "start": 275, "end": 279}]}}, "schema": []}
{"input": "The pulpal tissues of the permanent mandibular molars were amputated and then dressed with calcium hydrate.", "output": {"entities": {}}, "schema": []}
{"input": "Northern blot analyses demonstrate that 3. 9-and 5-kilobase mRNAs corresponding to the cDNA were present in all tissues examined, suggesting that the protein it encodes performs a housekeeping function.", "output": {"entities": {}}, "schema": []}
{"input": "The ARG SH2 domain exhibited relatively weak affinity for BCR and was determined to bind about 10-fold less strongly than the ABL SH2 domain.", "output": {"entities": {"gene": [{"text": "ARG SH2 domain", "start": 4, "end": 18}, {"text": "BCR", "start": 58, "end": 61}, {"text": "ABL SH2 domain", "start": 126, "end": 140}]}}, "schema": []}
{"input": "We analyzed an EBV B-cell clone, E29. 1, derived from an 11 week-old embryo, and secreting both IgM kappa and IgM lambda.", "output": {"entities": {"gene": [{"text": "IgM kappa", "start": 96, "end": 105}, {"text": "IgM lambda", "start": 110, "end": 120}]}}, "schema": []}
{"input": "Interestingly, this activation occurred only when the regions were cloned in the same relative orientation in which they exist on wild-type pCF10.", "output": {"entities": {}}, "schema": []}
{"input": "In rats, we examined the effect of an omentum wrapping on the vascularization of the trachea and on regeneration of the mucosal epithelium in the very early stage after free tracheal grafting.", "output": {"entities": {}}, "schema": []}
{"input": "To study a possible functional role of this putative chicken ICS, an oligonucleotide spanning the upstream sequences of the BF-IV gene (-174/-194) was cloned singly or in multiple copies before the herpes TK promoter controlling the chloramphenicol acetyl transferase (CAT) gene (pBLCAT2).", "output": {"entities": {"gene": [{"text": "ICS", "start": 61, "end": 64}, {"text": "BF-IV gene", "start": 124, "end": 134}, {"text": "TK promoter", "start": 205, "end": 216}, {"text": "chloramphenicol acetyl transferase", "start": 233, "end": 267}, {"text": "CAT", "start": 269, "end": 272}, {"text": "pBLCAT2", "start": 280, "end": 287}]}}, "schema": []}
{"input": "In general, two separate high-performance liquid chromatographic runs were performed, one for the gamma-aminobutyric acid determination and one for the determination of the monoamines.", "output": {"entities": {}}, "schema": []}
{"input": "We report the successful use of electroconvulsive therapy for treatment of severe depression in a young man with adult GM2 gangliosidosis.", "output": {"entities": {}}, "schema": []}
{"input": "Through Southern blot analyses of DNA from backcross and cogenic mice, recombinant inbred strains, and somatic cell hybrids, the genetic loci that produce the cyclin B1-related sequences (designated loci Cycb1-rs1 to Cycb1-rs9) were mapped on mouse chromosomes 5, 1, 17, 4, 14, 13, 7, X, and 8, respectively.", "output": {"entities": {"gene": [{"text": "cyclin B1-related sequences", "start": 159, "end": 186}, {"text": "loci Cycb1-rs1", "start": 199, "end": 213}, {"text": "Cycb1-rs9", "start": 217, "end": 226}]}}, "schema": []}
{"input": "Again residue Glu-381 of beta was notably reduced and no missing residue from the epsilon peptide could be identified, but the peptide sequence limited the possible choices to Ser-106, Ser-107, or Ser-108.", "output": {"entities": {}}, "schema": []}
{"input": "Porcelain to dentin bond strength with a dentin adhesive.", "output": {"entities": {}}, "schema": []}
{"input": "TBPf is defined as a quotient of the difference of the first and the second measurement: TBPf = (P1-P2)/(A1-A2).", "output": {"entities": {}}, "schema": []}
{"input": "It was concluded that Scotchbond 2 and Prisma Universal Bond 2 are effective and are the dentine bonding agents of choice.", "output": {"entities": {}}, "schema": []}
{"input": "The neurohypophysial vasopressin and oxytocin content was bioassayed by pressor effect following Dekanski or milk-ejection activity in vitro following van Dongen and Hays, respectively.", "output": {"entities": {"gene": [{"text": "vasopressin", "start": 21, "end": 32}, {"text": "oxytocin", "start": 37, "end": 45}]}}, "schema": []}
{"input": "Comments are given on the present status of regulations concerning water in swimming pools and baths--1991--(in connection with the KOK regulations--1972--and the Federal German standard [DIN] No.", "output": {"entities": {}}, "schema": []}
{"input": "If no reply was received, telephone contact or home visits were made.", "output": {"entities": {}}, "schema": []}
{"input": "The treatment group also showed in vivo T-cell activation with an initial lymphopenia followed by a rebound lymphocytosis and upregulation of the subset markers CD25 (interleukin 2 receptor) and CD45RO (T-memory cells).", "output": {"entities": {"gene": [{"text": "CD25", "start": 161, "end": 165}, {"text": "interleukin 2 receptor", "start": 167, "end": 189}, {"text": "CD45RO", "start": 195, "end": 201}]}}, "schema": []}
{"input": "Urease activity, judged as the amount of ammonia production from urea, could be measured at 25 ng per tube (S/N = 1. 5) with Jack bean meal urease.", "output": {"entities": {"gene": [{"text": "Urease", "start": 0, "end": 6}, {"text": "Jack bean meal urease", "start": 125, "end": 146}]}}, "schema": []}
{"input": "Although a wide range of cognitive functions had been tested, all but one seizure occurred during assessment of memory performance.", "output": {"entities": {}}, "schema": []}
{"input": "The experiments show that it is the micromilieu of the alveoli and the condition of the AM (certain physiological activation states, such as phagocytic activity) that essentially determine the degree of recovery.", "output": {"entities": {}}, "schema": []}
{"input": "A cDNA library of tumour cells was screened with an interleukin 2 gene-specific probe.", "output": {"entities": {"gene": [{"text": "interleukin 2", "start": 52, "end": 65}]}}, "schema": []}
{"input": "Our experiments suggest that the SCL gene can be a target for the erythroid transcription factor GATA-1 and that the SCL gene product serves as a positive regulator of erythroid differentiation.", "output": {"entities": {"gene": [{"text": "SCL gene", "start": 33, "end": 41}, {"text": "erythroid transcription factor GATA-1", "start": 66, "end": 103}, {"text": "SCL gene product", "start": 117, "end": 133}]}}, "schema": []}
{"input": "Complexes containing wild-type and either his175 or his273 mutant p53 proteins are completely unable to bind to the RGC DNA sequence.", "output": {"entities": {"gene": [{"text": "his175 or his273 mutant p53 proteins", "start": 42, "end": 78}, {"text": "RGC DNA sequence", "start": 116, "end": 132}]}}, "schema": []}
{"input": "These temperature-and cold-sensitive strains were used to prepare extracts deficient in BRF1 activity and were tested for transcriptional activity by RNA polymerases I, II, and III in vitro.", "output": {"entities": {"gene": [{"text": "BRF1", "start": 88, "end": 92}, {"text": "RNA polymerases I, II, and III", "start": 150, "end": 180}]}}, "schema": []}
{"input": "These results lead us to hypothesize that a single multisubunit TFIID protein supports transcriptional stimulation by diverse activation domains and from a TATA-less promoter.", "output": {"entities": {"gene": [{"text": "multisubunit TFIID protein", "start": 51, "end": 77}]}}, "schema": []}
{"input": "Clone pSRc200 hybrid selected an mRNA that on cell-free translation produced a 38-kDa polypeptide.", "output": {"entities": {}}, "schema": []}
{"input": "From these results, CBF-A is a novel CArG box-, ssDNA-and RNA-binding protein, as well as a repressive transcriptional factor.", "output": {"entities": {"gene": [{"text": "CBF-A", "start": 20, "end": 25}, {"text": "ssDNA-and RNA-binding protein", "start": 48, "end": 77}]}}, "schema": []}
{"input": "Cleavage by the intron-encoded enzyme (I-CreI) occurs 5 bp and 1 bp 3' to the intron insertion site (in the 3'-exon) in the top (/) and bottom (,) strands, respectively, resulting in 4-nt single-stranded overhangs with 3'-OH termini.", "output": {"entities": {"gene": [{"text": "I-CreI", "start": 39, "end": 45}]}}, "schema": []}
{"input": "Surprisingly, the Xenopus U7 gene contains two adjacent octamer-binding motifs located only 12 and 24 bp upstream from the PSE, instead of the usual location around 150-200 bp upstream.", "output": {"entities": {"gene": [{"text": "Xenopus U7 gene", "start": 18, "end": 33}, {"text": "PSE", "start": 123, "end": 126}]}}, "schema": []}
{"input": "The results support earlier reports that collagenase inhibitors are useful in controlling blister formation in recessive dystrophic epidermolysis bullosa.", "output": {"entities": {"gene": [{"text": "collagenase", "start": 41, "end": 52}]}}, "schema": []}
{"input": "In humans, four AMP deaminase variants, termed M (muscle), L (liver), E1, and E2 (erythrocyte) can be distinguished by a variety of biochemical and immunological criteria.", "output": {"entities": {"gene": [{"text": "AMP deaminase variants", "start": 16, "end": 38}, {"text": "M", "start": 47, "end": 48}, {"text": "L", "start": 59, "end": 60}, {"text": "E1", "start": 70, "end": 72}, {"text": "E2", "start": 78, "end": 80}]}}, "schema": []}
{"input": "Western blot analyses detect anti-E-specific immunoreactivity in affinity-purified extracts derived from the bacterial expression of a truncated AMPD3 cDNA.", "output": {"entities": {"gene": [{"text": "anti-E", "start": 29, "end": 35}, {"text": "truncated AMPD3 cDNA", "start": 135, "end": 155}]}}, "schema": []}
{"input": "These results demonstrate that endogenous N-methylation of salsolinol into N-methylsalsolinol occurs in the brain in vivo.", "output": {"entities": {}}, "schema": []}
{"input": "DR1 molecules purified from human lymphoblastoid cell lines could specifically bind to these peptide sequences expressed on the phage surface.", "output": {"entities": {"gene": [{"text": "DR1 molecules", "start": 0, "end": 13}]}}, "schema": []}
{"input": "This article describes the collaborative care of the woman participating in maternal blood donation for intrauterine transfusion.", "output": {"entities": {}}, "schema": []}
{"input": "Chronic hepatitis B in adopted Romanian children.", "output": {"entities": {}}, "schema": []}
{"input": "Behind the ATPase cluster, two open reading frames were detected that are not homologous to any known chloroplast gene.", "output": {"entities": {"gene": [{"text": "ATPase cluster", "start": 11, "end": 25}]}}, "schema": []}
{"input": "Therefore, recombinant human Ads that express noninfectious HIV or other microbial proteins are attractive vaccine candidates.", "output": {"entities": {}}, "schema": []}
{"input": "Alignment of the selected sequences allowed us to predict a consensus sequence for binding of the individual homodimeric Rel-related proteins, and DNA-protein binding analysis of the selected DNA sequences revealed sequence specificity of the proteins.", "output": {"entities": {"gene": [{"text": "Rel-related proteins", "start": 121, "end": 141}]}}, "schema": []}
{"input": "Using either a p50-or p65-selected kappa B motif, which displayed differential binding with respect to the other protein, little to no binding was observed with the heterodimeric NF-kappa B complex.", "output": {"entities": {"gene": [{"text": "p50", "start": 15, "end": 18}, {"text": "p65-selected kappa B motif", "start": 22, "end": 48}, {"text": "heterodimeric NF-kappa B complex", "start": 165, "end": 197}]}}, "schema": []}
{"input": "However, a cosmid clone containing the entire mouse alpha 1 (I) gene, including 3. 7 kb of 5'-and 4 kb of 3'-flanking DNA, was expressed at reduced levels in fibroblasts overexpressing oncogenic ras.", "output": {"entities": {"gene": [{"text": "mouse alpha 1 (I) gene", "start": 46, "end": 68}, {"text": "oncogenic ras", "start": 185, "end": 198}]}}, "schema": []}
{"input": "To define transcriptional control elements responsible for muscle-specific expression of the human myoglobin gene, we performed mutational analysis of upstream sequences (nucleotide positions-373 to + 7 relative to the transcriptional start site) linked to a firefly luciferase gene.", "output": {"entities": {"gene": [{"text": "human myoglobin gene", "start": 93, "end": 113}, {"text": "firefly luciferase gene", "start": 259, "end": 282}]}}, "schema": []}
{"input": "Sequencing analysis has shown that each rap1t allele contains a nonsense mutation within a discrete region between amino acids 663 and 684.", "output": {"entities": {"gene": [{"text": "rap1t allele", "start": 40, "end": 52}]}}, "schema": []}
{"input": "By screening a Y1 cell cDNA library with the DNA-binding region of the H-2RIIBP nuclear hormone receptor cDNA, we isolated a cDNA that is selectively expressed in steroidogenic cells.", "output": {"entities": {"gene": [{"text": "H-2RIIBP nuclear hormone receptor cDNA", "start": 71, "end": 109}]}}, "schema": []}
{"input": "Autopsy demonstrated good survival of the transplanted cells with good integration with the brain of the recipient and traces of positive immunocytochemical reaction for tyrosine hydroxylase.", "output": {"entities": {"gene": [{"text": "tyrosine hydroxylase", "start": 170, "end": 190}]}}, "schema": []}
{"input": "The technique of the TEE visualization of the proximal coronary arteries is described.", "output": {"entities": {}}, "schema": []}
{"input": "The sequence of this region shows high G + C content (62%), which is particularly emphasized in the 200 bp upstream from the mRNA start (80% G + C).", "output": {"entities": {}}, "schema": []}
{"input": "PaO2 threshold was determined through an indwelling O2 sensor catheter.", "output": {"entities": {}}, "schema": []}
{"input": "By using lambda gt11 expression cloning with oligonucleotides corresponding to the human immunodeficiency virus 1 TATA element, we report the identification of a cellular protein with a calculated molecular mass of 123 kDa that we designate TATA element modulatory factor (TMF).", "output": {"entities": {"gene": [{"text": "TATA element modulatory factor", "start": 241, "end": 271}, {"text": "TMF", "start": 273, "end": 276}]}}, "schema": []}
{"input": "Blood levels of melatonin, serotonin, cortisol, and prolactin in relation to the circadian rhythm of platelet serotonin uptake.", "output": {"entities": {"gene": [{"text": "prolactin", "start": 52, "end": 61}]}}, "schema": []}
{"input": "We couldn' t detect any effect of n-3 FA supplementation on total cholesterol, HDL cholesterol, LDL cholesterol, apo A1, Lp (a), HbA1C, glucose, fibrinogen, factor VIII, antithrombin III, plasminogen activator inhibitor, tissue plasminogen activator and von Willebrand factor concentration, on bleeding time or on systolic or diastolic blood pressure.", "output": {"entities": {"gene": [{"text": "HDL cholesterol", "start": 79, "end": 94}, {"text": "LDL cholesterol", "start": 96, "end": 111}, {"text": "apo A1", "start": 113, "end": 119}, {"text": "Lp (a)", "start": 121, "end": 127}, {"text": "HbA1C", "start": 129, "end": 134}, {"text": "fibrinogen", "start": 145, "end": 155}, {"text": "factor VIII", "start": 157, "end": 168}, {"text": "antithrombin III", "start": 170, "end": 186}, {"text": "plasminogen activator inhibitor", "start": 188, "end": 219}, {"text": "tissue plasminogen activator", "start": 221, "end": 249}, {"text": "von Willebrand factor", "start": 254, "end": 275}]}}, "schema": []}
{"input": "In 8 healthy volunteers there were no significant differences in AUC, peak plasma concentrations or time to peak concentration when OXC was administered either with or without ERY.", "output": {"entities": {}}, "schema": []}
{"input": "Using 5 ng/mL as the cutoff, the sensitivity of CEA was 68%.", "output": {"entities": {"gene": [{"text": "CEA", "start": 48, "end": 51}]}}, "schema": []}
{"input": "Rolandic spikes and cognitive function.", "output": {"entities": {}}, "schema": []}
{"input": "The effect of sodium 18 beta-glycyrrhetate (SGA) on experimental arrhythmia was investigated.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, chronic hematocrit decrease induced by H or P resulted in a significant fall in blood pressure compared to control (201 +/-3 v 175 +/-4, 167 +/-4 mm Hg, respectively; P <. 05).", "output": {"entities": {}}, "schema": []}
{"input": "The effects of diltiazem were stereoselective, thus the potentiation induced by d-cis diltiazem was significantly greater in all cases than that induced by l-cis diltiazem, which suggests that calcium channel blockade plays a role in these interactions.", "output": {"entities": {}}, "schema": []}
{"input": "Substitution of either Val33 (by Gly) or Gly28 (by Ser), two of the most conserved residues in all protein kinases, resulted in enzyme with marginally detectable activity.", "output": {"entities": {}}, "schema": []}
{"input": "Significance of the biopsy site of the latissimus dorsi muscle for fiber typing.", "output": {"entities": {}}, "schema": []}
{"input": "The TIMP (-59/-53) AP1 site is a promiscuous motif that binds c-Fos/c-Jun AP1 translated in vitro and is an effective competitor for binding of nuclear AP1 factors to the consensus TRE, but in addition it binds factors that do not associate with the consensus TRE.", "output": {"entities": {"gene": [{"text": "TIMP", "start": 4, "end": 8}, {"text": "AP1", "start": 19, "end": 22}, {"text": "c-Fos", "start": 62, "end": 67}, {"text": "c-Jun AP1", "start": 68, "end": 77}, {"text": "nuclear AP1 factors", "start": 144, "end": 163}]}}, "schema": []}
{"input": "Involvement of AP1 and PEA3 binding sites in the regulation of murine tissue inhibitor of metalloproteinases-1 (TIMP-1) transcription.", "output": {"entities": {"gene": [{"text": "AP1", "start": 15, "end": 18}, {"text": "PEA3 binding sites", "start": 23, "end": 41}, {"text": "murine tissue inhibitor of metalloproteinases-1", "start": 63, "end": 110}, {"text": "TIMP-1", "start": 112, "end": 118}]}}, "schema": []}
{"input": "Of the serum neutralizing (SN) antibody negative calves 89. 7% (26/29) and 92. 8% (90/97) developed SN antibody 1 month after intranasal and intramuscular vaccination, respectively.", "output": {"entities": {"gene": [{"text": "serum neutralizing (SN) antibody", "start": 7, "end": 39}, {"text": "SN antibody", "start": 100, "end": 111}]}}, "schema": []}
{"input": "Fractionation of crude nuclear extracts by heparin-agarose chromatography indicates that PCAT-1 is more prevalent in extracts prepared from salt-stressed leaf tissue.", "output": {"entities": {"gene": [{"text": "PCAT-1", "start": 89, "end": 95}]}}, "schema": []}
{"input": "A controlled trial of recombinant human granulocyte-macrophage colony-stimulating factor after total body irradiation, high-dose chemotherapy, and autologous bone marrow transplantation for acute lymphoblastic leukemia or malignant lymphoma.", "output": {"entities": {"gene": [{"text": "recombinant human granulocyte-macrophage colony-stimulating factor", "start": 22, "end": 88}]}}, "schema": []}
{"input": "These data demonstrate that DMVA does not cause more myocardial trauma than CPB when used to provide resuscitative circulatory support.", "output": {"entities": {}}, "schema": []}
{"input": "The IgG subclass profile of untreated coeliac disease was found to be the same as in healthy controls (IgG1 approximately IgG2 > IgG3 > IgG4), with only the magnitude of the individual subclass responses being increased in coeliac patients.", "output": {"entities": {"gene": [{"text": "IgG", "start": 4, "end": 7}, {"text": "IgG1", "start": 103, "end": 107}, {"text": "IgG2", "start": 122, "end": 126}, {"text": "IgG3", "start": 129, "end": 133}, {"text": "IgG4", "start": 136, "end": 140}]}}, "schema": []}
{"input": "Examination of ANCA is not only a significant contribution towards a more accurate diagnosis of renal vasculitis, but also an indicator of the activity of the disease and thus of the effectiveness of immunosuppressive treatment.", "output": {"entities": {"gene": [{"text": "ANCA", "start": 15, "end": 19}]}}, "schema": []}
{"input": "On the other hand, total pinealectomy in these already sympathectomized blinded rabbits always resulted in a substantial deceleration of the rhythms (mean delta tau = + 0. 23 h).", "output": {"entities": {}}, "schema": []}
{"input": "Cicatricial pemphigoid is an autoimmune systemic disease characterized by chronic conjunctival cicatrization.", "output": {"entities": {}}, "schema": []}
{"input": "The effects of two levels of caffeine ingestion on excess postexercise oxygen consumption in untrained women.", "output": {"entities": {}}, "schema": []}
{"input": "The distinguishing features involved eight amino acid changes, including a single lysine deletion relative to a primate consensus sequence in the first complementary-determing region of V1J1.", "output": {"entities": {"gene": [{"text": "V1J1", "start": 186, "end": 190}]}}, "schema": []}
{"input": "4.", "output": {"entities": {}}, "schema": []}
{"input": "The in vivo profile of ZFH-2 in the larval CNS shows intriguing overlap with DDC in specific serotonin and dopamine neurons.", "output": {"entities": {"gene": [{"text": "ZFH-2", "start": 23, "end": 28}, {"text": "DDC", "start": 77, "end": 80}]}}, "schema": []}
{"input": "Unlike the introns of other duplicated ribosomal protein genes which are highly diverged, the duplicated S13 genes have two nearly identical DNA sequences of 25 and 31 bp in length within their introns.", "output": {"entities": {"gene": [{"text": "ribosomal protein genes", "start": 39, "end": 62}, {"text": "S13 genes", "start": 105, "end": 114}]}}, "schema": []}
{"input": "In a prospective, randomized clinical trial we compared the efficacy of subcutaneously (SC) administered (every 8 h) calcium heparin to intravenous (IV) sodium heparin in the treatment of proximal deep-vein thrombosis (DVT).", "output": {"entities": {}}, "schema": []}
{"input": "The highest prevalence of reported pet allergy, chronic cough, wheeze, attacks of shortness of breath with wheezing, and doctor-diagnosed asthma was found in children who had pets in the past but not anymore.", "output": {"entities": {}}, "schema": []}
{"input": "Therefore, it would be advantageous to identify such persons and treat them preferentially.", "output": {"entities": {}}, "schema": []}
{"input": "On the basis of these unique properties, the newly characterized hemagglutinin has been termed Limulus 18K agglutination-aggregation factor (18K-LAF).", "output": {"entities": {"gene": [{"text": "hemagglutinin", "start": 65, "end": 78}, {"text": "Limulus 18K agglutination-aggregation factor", "start": 95, "end": 139}, {"text": "18K-LAF", "start": 141, "end": 148}]}}, "schema": []}
{"input": "The shift to the nonpermissive temperature is accompanied by the loss of guanyl nucleotide-dependent activity of adenylylcyclase in vitro.", "output": {"entities": {"gene": [{"text": "adenylylcyclase", "start": 113, "end": 128}]}}, "schema": []}
{"input": "Clin.", "output": {"entities": {}}, "schema": []}
{"input": "The data indicate that the minimal catalytic domain of Nmt1p is located between Ile59--> Phe96 and Gly451--> Leu455.", "output": {"entities": {"gene": [{"text": "Nmt1p", "start": 55, "end": 60}]}}, "schema": []}
{"input": "It corresponds to the complete mitochondrial presequence and the lipoyl-bearing domain that are encoded by exons I through IV of the functional E2 gene.", "output": {"entities": {"gene": [{"text": "E2 gene", "start": 144, "end": 151}]}}, "schema": []}
{"input": "Human neutrophil response to short-term exposure to F-75 cobalt-based alloy.", "output": {"entities": {}}, "schema": []}
{"input": "Disruption of microtubules did not affect the fidelity or kinetics of vacuolar protein sorting, indicating that Vps1p function is not dependent on microtubules.", "output": {"entities": {"gene": [{"text": "Vps1p", "start": 112, "end": 117}]}}, "schema": []}
{"input": "A mutant form of Vps1p lacking the entire GTP-binding domain interfered with vacuolar protein sorting in wild-type cells.", "output": {"entities": {"gene": [{"text": "Vps1p", "start": 17, "end": 22}]}}, "schema": []}
{"input": "According to out field research, the tick fauna was very rich throughout that area, and it was permissible enough to determine ticks as the vectors, based on arising of anti-SF group rickettsiae (SFGR) antibody in mice inoculated with some tick emulsions, findings of rickettsiae reactive to patient sera or a species-specific monoclonal antibody to JSFR in the hemolymph cells of some ticks, and electron microscopical observations of SFGR in various internal organs including the salivary gland of ticks.", "output": {"entities": {"gene": [{"text": "anti-SF group rickettsiae", "start": 169, "end": 194}, {"text": "SFGR", "start": 196, "end": 200}, {"text": "JSFR", "start": 350, "end": 354}, {"text": "SFGR", "start": 436, "end": 440}]}}, "schema": []}
{"input": "Nucleotide sequence and transcriptional analysis of the polyhedrin gene of Spodoptera exigua nuclear polyhedrosis virus.", "output": {"entities": {"gene": [{"text": "polyhedrin gene", "start": 56, "end": 71}]}}, "schema": []}
{"input": "Validation of automated systems--system definition.", "output": {"entities": {}}, "schema": []}
{"input": "As a consequence of dark rearing, the numerical density of cortical neurons in area 17 amounted to about double of the value observed in normally reared kittens and was also significantly higher in area 18.", "output": {"entities": {}}, "schema": []}
{"input": "These results suggest that decreased class I enhancer activity in Ad12-transformed cells may, at least in part, be due to the higher levels of an enhancer-specific factor, possibly acting as a repressor.", "output": {"entities": {}}, "schema": []}
{"input": "A second domain, located in the C-terminal 437 amino acids of IE1, is required for inhibitory and DNA-binding activities.", "output": {"entities": {"gene": [{"text": "IE1", "start": 62, "end": 65}]}}, "schema": []}
{"input": "In order to investigate the blood compatibility of autogenous vein graft (AVG), changes in prostacyclin (PGI2) production following harvesting and arterial implantation were studied experimentally.", "output": {"entities": {}}, "schema": []}
{"input": "Subcutaneous administration of the somatostatin analogue, octreotide, 100 micrograms thrice daily, resulted in a sustained improvement in diarrhoea and disappearance of faecal incontinence without reducing calcitonin levels.", "output": {"entities": {"gene": [{"text": "somatostatin", "start": 35, "end": 47}, {"text": "calcitonin", "start": 206, "end": 216}]}}, "schema": []}
{"input": "205, 285-290] and was subsequently cloned and sequenced [J.", "output": {"entities": {}}, "schema": []}
{"input": "Nonreplicating vaccinia vector efficiently expresses recombinant genes.", "output": {"entities": {}}, "schema": []}
{"input": "Interferon type I in protective body reactions in an experimental Klebsiella infection", "output": {"entities": {"gene": [{"text": "Interferon type I", "start": 0, "end": 17}]}}, "schema": []}
{"input": "No other changes in hematopoietic differentiation status were observed in association with Id-SCL expression.", "output": {"entities": {"gene": [{"text": "Id-SCL", "start": 91, "end": 97}]}}, "schema": []}
{"input": "For pressure greater than 121 atm abs, an increased excitability of the tadpoles made it difficult to distinguish the righting reflex from involuntary movements.", "output": {"entities": {}}, "schema": []}
{"input": "One air embolism occurred; this was the only filter-or retrieval-related complication.", "output": {"entities": {}}, "schema": []}
{"input": "The 5' region of ADH5 contains consensus binding sites for the transcriptional regulatory proteins, Sp1, AP2, LF-A1, NF-1, NF-A2, and NF-E1.", "output": {"entities": {"gene": [{"text": "ADH5", "start": 17, "end": 21}, {"text": "Sp1", "start": 100, "end": 103}, {"text": "AP2", "start": 105, "end": 108}, {"text": "LF-A1", "start": 110, "end": 115}, {"text": "NF-1", "start": 117, "end": 121}, {"text": "NF-A2", "start": 123, "end": 128}, {"text": "NF-E1", "start": 134, "end": 139}]}}, "schema": []}
{"input": "These data indicate that RNK-Met-1 is a serine protease with unique activity that is expressed in the granules of large granular lymphocytes.", "output": {"entities": {"gene": [{"text": "RNK-Met-1", "start": 25, "end": 34}, {"text": "serine protease", "start": 40, "end": 55}]}}, "schema": []}
{"input": "Purification and cloning of a novel serine protease, RNK-Met-1, from the granules of a rat natural killer cell leukemia.", "output": {"entities": {"gene": [{"text": "serine protease", "start": 36, "end": 51}, {"text": "RNK-Met-1", "start": 53, "end": 62}]}}, "schema": []}
{"input": "We describe here 17 dominant GCN2 mutations that lead to derepression of GCN4 expression in the absence of amino acid starvation.", "output": {"entities": {"gene": [{"text": "dominant GCN2 mutations", "start": 20, "end": 43}, {"text": "GCN4", "start": 73, "end": 77}]}}, "schema": []}
{"input": "Administration of growth hormone leads to faster growth, but also faster bone maturation.", "output": {"entities": {"gene": [{"text": "growth hormone", "start": 18, "end": 32}]}}, "schema": []}
{"input": "Comparisons with the available amino acid residue (aa) sequence information from the complete CPMV RNA 1 sequence and the partial sequence of red clover mottle virus RNA 1 suggest that CPSMV RNA 1 specifies the expected set of five mature proteins: 32K proteinase cofactor, 58K presumed helicase, VPg 5'-linked protein of the genomic RNAs, 24K proteinase, and 87K presumed polymerase, separated by four cleavage sites.", "output": {"entities": {"gene": [{"text": "CPMV RNA 1 sequence", "start": 94, "end": 113}, {"text": "red clover mottle virus RNA 1", "start": 142, "end": 171}, {"text": "CPSMV RNA 1", "start": 185, "end": 196}, {"text": "32K proteinase cofactor", "start": 249, "end": 272}, {"text": "58K presumed helicase", "start": 274, "end": 295}, {"text": "VPg 5'-linked protein", "start": 297, "end": 318}, {"text": "24K proteinase", "start": 340, "end": 354}, {"text": "87K presumed polymerase", "start": 360, "end": 383}]}}, "schema": []}
{"input": "In addition, the utility of beta 2 transferrin assay in the diagnosis of cerebrospinal fluid otorrhea is presented.", "output": {"entities": {"gene": [{"text": "beta 2 transferrin", "start": 28, "end": 46}]}}, "schema": []}
{"input": "The addition of diatrizoate to the IPRK led to a dose-dependent biphasic change in RPF and GFR characterized by an initial transient increase followed by a marked and sustained decrease.", "output": {"entities": {}}, "schema": []}
{"input": "To prepare for analyses with the family variables, we next present descriptive data based on separate principal components analysis (PCA) and multidimensional scaling analysis (MDS) of 14 self-reported health scores for husbands and for wives.", "output": {"entities": {}}, "schema": []}
{"input": "The structural genes encoding glyceraldehyde-3-phosphate dehydrogenase (GAPDH), 3-phosphoglycerate kinase (PGK) and the N-terminal part of triosephosphate isomerase (TIM) from mesophilic Bacillus megaterium DSM319 have been cloned as a gene cluster (gap operon) by complementation of an Escherichia coli gap amber mutant.", "output": {"entities": {"gene": [{"text": "glyceraldehyde-3-phosphate dehydrogenase", "start": 30, "end": 70}, {"text": "GAPDH", "start": 72, "end": 77}, {"text": "3-phosphoglycerate kinase", "start": 80, "end": 105}, {"text": "PGK", "start": 107, "end": 110}, {"text": "triosephosphate isomerase", "start": 139, "end": 164}, {"text": "TIM", "start": 166, "end": 169}, {"text": "gap operon", "start": 250, "end": 260}, {"text": "gap amber mutant", "start": 304, "end": 320}]}}, "schema": []}
{"input": "Pseudomonas aeruginosa exotoxin A: its role in retardation of wound healing: the 1992 Lindberg Award.", "output": {"entities": {"gene": [{"text": "Pseudomonas aeruginosa exotoxin A", "start": 0, "end": 33}]}}, "schema": []}
{"input": "Laboratory studies showed that the direct fluorescent-antibody kits were the least sensitive in this case and did not detect fewer than 10 (4) elementary bodies per ml, while most ELISA kits detected between 130 and 600 elementary bodies per ml.", "output": {"entities": {}}, "schema": []}
{"input": "To study the significance of these domains and the overall evolutionary conservation of the gene, the homolog from Drosophila melanogaster was isolated by low stringency hybridizations using two flanking probes of the human ERCC3 cDNA.", "output": {"entities": {"gene": [{"text": "human ERCC3 cDNA", "start": 218, "end": 234}]}}, "schema": []}
{"input": "Mono-ADP-ribosylation is a reversible modification of proteins, with NAD: arginine ADP-ribosyltransferases (EC 2. 4. 2. 31) and ADP-ribosylarginine hydrolases (EC 3. 2. 2. 19) catalyzing the opposing reactions in an ADP-ribosylation cycle.", "output": {"entities": {"gene": [{"text": "arginine ADP-ribosyltransferases", "start": 74, "end": 106}, {"text": "EC 2. 4. 2. 31", "start": 108, "end": 122}, {"text": "ADP-ribosylarginine hydrolases", "start": 128, "end": 158}, {"text": "EC 3. 2. 2. 19", "start": 160, "end": 174}]}}, "schema": []}
{"input": "For this reason, the particle forming capacity of derivatives of the HIV-1 group specific core antigen p55 gag was assayed and compared dependent on various expression systems: recombinant bacteria, vaccinia-and baculoviruses were established encoding the entire core protein p55 either in its authentic sequence or lacking the myristylation consensus signal.", "output": {"entities": {"gene": [{"text": "HIV-1 group specific core antigen p55 gag", "start": 69, "end": 110}, {"text": "core protein p55", "start": 263, "end": 279}]}}, "schema": []}
{"input": "The tramtrack (ttk) gene of Drosophila encodes 69-kDa and 88-kDa proteins through alternative splicing of the primary ttk transcript.", "output": {"entities": {"gene": [{"text": "tramtrack", "start": 4, "end": 13}, {"text": "ttk", "start": 15, "end": 18}, {"text": "ttk transcript", "start": 118, "end": 132}]}}, "schema": []}
{"input": "Removal of beta 2-microglobulin by hemodialysis and hemofiltration: a four year follow up.", "output": {"entities": {"gene": [{"text": "beta 2-microglobulin", "start": 11, "end": 31}]}}, "schema": []}
{"input": "Removal of beta 2-microglobulin by hemodialysis and hemofiltration: a four year follow up.", "output": {"entities": {"gene": [{"text": "beta 2-microglobulin", "start": 11, "end": 31}]}}, "schema": []}
{"input": "Adapromine was established to evoke a decrease of the amplitude of the dominant peak and dominant theta-activity in power spectra of the EEG in the cortex and hippocamp, with an increase of rapid wave activity in the beta 2 range in the right cortex and hippocamp.", "output": {"entities": {}}, "schema": []}
{"input": "These sequences were then used to clone the full-length genes from a yeast genomic library.", "output": {"entities": {}}, "schema": []}
{"input": "GAL4-VP16-mediated antirepression required an auxiliary factor, denoted as a co-antirepressor, which was partially purified from Drosophila embryos.", "output": {"entities": {"gene": [{"text": "GAL4", "start": 0, "end": 4}, {"text": "VP16", "start": 5, "end": 9}]}}, "schema": []}
{"input": "After 28 days of haloperidol treatment, similar changes were observed for delta, together with an increase of alpha 1, and a decrease of fast beta.", "output": {"entities": {}}, "schema": []}
{"input": "Four ruminally and duodenally cannulated Hampshire wethers were used in a 4 x 4 Latin square experiment to determine whether linoleoyl methionine and calcium linoleate would increase duodenal flow of unsaturated fatty acids (C18: 2 + cis C18: 1).", "output": {"entities": {}}, "schema": []}
{"input": "Truncated ICSBP lacking the first 33 amino-terminal amino acids fails to bind to the ICS, indicating that at least part of the DNA binding domain is located within the well conserved amino terminus.", "output": {"entities": {"gene": [{"text": "Truncated ICSBP", "start": 0, "end": 15}, {"text": "ICS", "start": 85, "end": 88}]}}, "schema": []}
{"input": "Therefore, ICSBP may be involved in maintaining submaximal transcriptional activity of IFN-inducible genes in hematopoietic cells.", "output": {"entities": {"gene": [{"text": "ICSBP", "start": 11, "end": 16}, {"text": "IFN", "start": 87, "end": 90}]}}, "schema": []}
{"input": "A case of chronic hepatitis C with primary hypothyroidism manifested during interferon treatment", "output": {"entities": {"gene": [{"text": "interferon", "start": 76, "end": 86}]}}, "schema": []}
{"input": "Dynamic decision making: human control of complex systems.", "output": {"entities": {}}, "schema": []}
{"input": "A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes.", "output": {"entities": {"gene": [{"text": "coiled-coil related protein", "start": 2, "end": 29}]}}, "schema": []}
{"input": "Abstracts.", "output": {"entities": {}}, "schema": []}
{"input": "These results indicate a possible involvement of endogenous opioid peptides in the cardiac effects due to myocardial ischaemia and reperfusion, mediated by opiate receptors through opiate antagonism.", "output": {"entities": {"gene": [{"text": "opiate receptors", "start": 156, "end": 172}]}}, "schema": []}
{"input": "Since CENP-B gene is conserved in mammalian species and CENP-B boxes are found also in mouse centromere satellite DNA (minor satellite), this sequence-specific DNA-protein interaction may be important for some kind of common centromere function.", "output": {"entities": {"gene": [{"text": "CENP-B gene", "start": 6, "end": 17}, {"text": "CENP-B boxes", "start": 56, "end": 68}]}}, "schema": []}
{"input": "Interestingly, a portion of the tail domain (aa, 1, 094-1, 830) shares 58% amino acid sequence identity with a 723-aa protein from mouse brain reported to be a glutamic acid decarboxylase.", "output": {"entities": {"gene": [{"text": "glutamic acid decarboxylase", "start": 160, "end": 187}]}}, "schema": []}
{"input": "However, in the subgroup with normal Ht (< 0. 45 l/l; n = 201) there was a significant reduction (p < 0. 05) of the mortality after 3 months (27% and 16%, respectively) and an increase of independence at home (35% and 48%, respectively) due to a reduction of the viscosity by means of haemodilution with albumin (a specific viscosity effect in the normovolaemic group).", "output": {"entities": {"gene": [{"text": "albumin", "start": 304, "end": 311}]}}, "schema": []}
{"input": "Distribution and changing morphological course", "output": {"entities": {}}, "schema": []}
{"input": "The appropriate use and benefits of bile acid sequestrants, nicotinic acid, fibric acids, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, and probucol are individually discussed, whereas nonpharmacologic approaches used in conjunction with the drugs are recommended emphatically.", "output": {"entities": {"gene": [{"text": "3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase", "start": 90, "end": 147}]}}, "schema": []}
{"input": "This may result in more reabsorption and hence reduced renal clearance.", "output": {"entities": {}}, "schema": []}
{"input": "The major pathological findings of the placenta were prematuration and hypoplasia.", "output": {"entities": {}}, "schema": []}
{"input": "Green pepper significantly inhibited N-nitrosothiazolidine-carboxylic acid formation relative to ascorbic acid alone.", "output": {"entities": {}}, "schema": []}
{"input": "A genomic clone, pTt21, containing DNA apparently transcribed specifically in Trypanosoma cruzi trypomastigotes, was obtained by differentially screening a genomic library with trypomastigote and epimastigote cDNA.", "output": {"entities": {}}, "schema": []}
{"input": "Brucellosis--1990", "output": {"entities": {}}, "schema": []}
{"input": "Assay of urea by immobilized urease coupled to a differential pH-meter.", "output": {"entities": {"gene": [{"text": "urease", "start": 29, "end": 35}]}}, "schema": []}
{"input": "RESULTS: In the AGA group, both fetal and maternal serum prolactin concentration increased significantly with gestation (P < 0. 001 and P < 0. 01, respectively).", "output": {"entities": {"gene": [{"text": "prolactin", "start": 57, "end": 66}]}}, "schema": []}
{"input": "One phage clone contains a junction between alpha satellite DNA and a novel low-copy repeated sequence.", "output": {"entities": {}}, "schema": []}
{"input": "The 5'-flanking region of the human lactoferrin gene was isolated from a human placental genomic library.", "output": {"entities": {"gene": [{"text": "human lactoferrin gene", "start": 30, "end": 52}]}}, "schema": []}
{"input": "Therefore, the molecular mechanisms of the estrogen action that govern the lactoferrin gene expression differ between mouse and human.", "output": {"entities": {"gene": [{"text": "lactoferrin gene", "start": 75, "end": 91}]}}, "schema": []}
{"input": "The CEM receives registration updates via an HL7 message and evaluates data dependencies in rules via an interface to the relational database.", "output": {"entities": {}}, "schema": []}
{"input": "Magnetic resonance spectroscopy (MRS) and imaging (MRI) are now well established techniques for the study of cellular metabolism and gross structure of muscle.", "output": {"entities": {}}, "schema": []}
{"input": "Simultaneously a greater NA was found with no change in plasma epinephrine response.", "output": {"entities": {}}, "schema": []}
{"input": "We investigated the diagnostic value of a new in vitro test, Pharmacia CAP System (Pharmacia Diagnostics AB, Uppsala, Sweden), for the quantitative measurement of allergen-specific IgE antibodies by comparison with RAST in 2 groups of patients, 71 atopic and 48 non-atopic.", "output": {"entities": {"gene": [{"text": "allergen-specific IgE antibodies", "start": 163, "end": 195}]}}, "schema": []}
{"input": "Patients receiving VPA showed differences in attention, visuomotor performance, verbal span and sensory discrimination tasks at T1, in visuomotor performance at T2 and in spatial span at T3, whereas no differences were detected at T4.", "output": {"entities": {}}, "schema": []}
{"input": "We found that the gene segment containing the mu m poly (A) signals, along with 536 bp of downstream flanking sequence, acted as a transcription terminator in both myeloma cells and L cell fibroblasts.", "output": {"entities": {}}, "schema": []}
{"input": "Alena is a nurse in Prague--she dreams of higher wages and a trip across the ocean", "output": {"entities": {}}, "schema": []}
{"input": "Dopamine neurons in subjects that received 6-OHDA were protected by pre-treatment with GBR-12909.", "output": {"entities": {}}, "schema": []}
{"input": "The results of this study demonstrate that strongyloidiasis was the cause of sudden death.", "output": {"entities": {}}, "schema": []}
{"input": "A second large group of disorders in pregnancy is caused by effects of infections of the mother without pathogens being transmitted to the embryo or the placenta.", "output": {"entities": {}}, "schema": []}
{"input": "Four short nucleotide sequences (boxes I to IV) contribute to the light responsiveness of the parsley chalcone synthase promoter.", "output": {"entities": {"gene": [{"text": "parsley chalcone synthase promoter", "start": 94, "end": 128}]}}, "schema": []}
{"input": "The case described is that of a 72-year-old man with ochronosis who suffered a hyperextension injury to his spine in a fall, resulting in a fracture through an ankylosed L2-L3 disk space.", "output": {"entities": {}}, "schema": []}
{"input": "The mean blood flow in the penile foreskin was estimated to be 15 ml/min/100 g and it increased to 150-200% after the induction of anesthesia, and then decreased to 72% at the tip of the created parameatal foreskin flap.", "output": {"entities": {}}, "schema": []}
{"input": "Exogenous LHRH is also known to facilitate mating behavior in several species.", "output": {"entities": {"gene": [{"text": "LHRH", "start": 10, "end": 14}]}}, "schema": []}
{"input": "The first 146 consecutive patients treated with EVL during the period from August, 1986 to July, 1989 are reported.", "output": {"entities": {}}, "schema": []}
{"input": "Replacing the aspartic acid with a lysine but not with an alanine or valine residue allowed formation of disulfide-linked dimers.", "output": {"entities": {}}, "schema": []}
{"input": "During V-A bypass, hemodynamics were stable.", "output": {"entities": {}}, "schema": []}
{"input": "Greater rupture force was required in the adult pigs than in the young pigs.", "output": {"entities": {}}, "schema": []}
{"input": "At rest AFF was significantly higher in UT (29%) as compared to AT (25%) and UEA (25%).", "output": {"entities": {}}, "schema": []}
{"input": "We investigated the smoking habits of relapsers 1 year after quitting in a smoking cessation trial using nicotine or placebo patches.", "output": {"entities": {}}, "schema": []}
{"input": "Exposure to hepatitis B virus in the general population of Hisayama, Japan: significance of isolated antibody to hepatitis B surface antigen in general population.", "output": {"entities": {"gene": [{"text": "hepatitis B surface antigen", "start": 113, "end": 140}]}}, "schema": []}
{"input": "Because of this latter phenomenon, we were able to identify a particular cysteine motif that was repeated multiple times in Dfurin2 but present only twice in mammalian furin.", "output": {"entities": {"gene": [{"text": "Dfurin2", "start": 124, "end": 131}, {"text": "mammalian furin", "start": 158, "end": 173}]}}, "schema": []}
{"input": "On the other hand, neither phosphate buffered saline injection into the ES nor primary KLH challenges of the ES were capable of elevating the threshold level and changing the latency.", "output": {"entities": {"gene": [{"text": "KLH", "start": 87, "end": 90}]}}, "schema": []}
{"input": "A newly developed broad-spectrum fluoroquinolone, levofloxacin (LVFX, DR-3355), was evaluated in vitro and in vivo in comparison with ciprofloxacin (CPFX), ofloxacin (OFLX) and norfloxacin (NFLX).", "output": {"entities": {}}, "schema": []}
{"input": "The mean serum creatinine levels were similar at one year (SPK 1. 8, KTA 1. 9 mg/d). (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {}}, "schema": []}
{"input": "Model predictions were in accord with the nine-year survival experience of women in the HIP trial, and, with the exception of women 40-44 years old, with HIP data on 18-year survival.", "output": {"entities": {}}, "schema": []}
{"input": "High-resolution computed tomography in the diagnosis of miliary tuberculosis.", "output": {"entities": {}}, "schema": []}
{"input": "Previously, we showed that SNF2, SNF5, and SNF6 function interdependently in transcriptional activation, possibly forming a heteromeric complex.", "output": {"entities": {"gene": [{"text": "SNF2", "start": 27, "end": 31}, {"text": "SNF5", "start": 33, "end": 37}, {"text": "SNF6", "start": 43, "end": 47}]}}, "schema": []}
{"input": "We show that LexA-GAL4 and LexA-Bicoid fusion proteins are both dependent on SNF2, SNF5, and SNF6 for activation of target genes containing one or multiple lexA operators.", "output": {"entities": {"gene": [{"text": "LexA", "start": 13, "end": 17}, {"text": "GAL4", "start": 18, "end": 22}, {"text": "LexA", "start": 27, "end": 31}, {"text": "Bicoid", "start": 32, "end": 38}, {"text": "SNF2", "start": 77, "end": 81}, {"text": "SNF5", "start": 83, "end": 87}, {"text": "SNF6", "start": 93, "end": 97}, {"text": "lexA operators", "start": 156, "end": 170}]}}, "schema": []}
{"input": "George T.", "output": {"entities": {}}, "schema": []}
{"input": "A lambda gt10 cDNA library was constructed from poly (A) + RNA of young green leaves of spinach.", "output": {"entities": {}}, "schema": []}
{"input": "NE and PR3 assist in the destruction of phagocytosed microorganisms, cleave the important connective-tissue protein elastin, and generate chemotactic activities by forming alpha 1-proteinase inhibitor complexes and elastin peptides.", "output": {"entities": {"gene": [{"text": "NE", "start": 0, "end": 2}, {"text": "PR3", "start": 7, "end": 10}, {"text": "connective-tissue protein elastin", "start": 90, "end": 123}, {"text": "alpha 1-proteinase inhibitor complexes", "start": 172, "end": 210}, {"text": "elastin peptides", "start": 215, "end": 231}]}}, "schema": []}
{"input": "Selected topics in pediatric ultrasonography--1992.", "output": {"entities": {}}, "schema": []}
{"input": "Methods included 24-hour dietary recall, menu weights, and recipe analysis.", "output": {"entities": {}}, "schema": []}
{"input": "Factors associated with afterdrop included age, end-of-surgery temperature (both positively) and body mass (negatively).", "output": {"entities": {}}, "schema": []}
{"input": "Both GH deficiency and impaired spinal growth may result in short stature, whereas the occurrence of early puberty in association with GH deficiency reduces the time available for GH therapy.", "output": {"entities": {"gene": [{"text": "GH", "start": 5, "end": 7}, {"text": "GH", "start": 135, "end": 137}, {"text": "GH", "start": 180, "end": 182}]}}, "schema": []}
{"input": "By contrast, d (T2AG3T) and d (T2G4T) form only the G-quadruplex monomer structures independent of K cation concentration as reported previously [Sen, D., & Gilbert, W.", "output": {"entities": {"gene": [{"text": "d (T2AG3T)", "start": 13, "end": 23}, {"text": "d (T2G4T)", "start": 28, "end": 37}]}}, "schema": []}
{"input": "Differentiating among renal stones.", "output": {"entities": {}}, "schema": []}
{"input": "IFI 16 mRNA was found to be constitutively expressed in lymphoid cells and in cell lines of both the T and B lineages.", "output": {"entities": {"gene": [{"text": "IFI 16 mRNA", "start": 0, "end": 11}]}}, "schema": []}
{"input": "Mitochondria-lytic action of warfarin in lymphocytes.", "output": {"entities": {}}, "schema": []}
{"input": "Exon-intron junctions in the human and rat AdoMet decarboxylase genes were in identical positions except that exons 6 and 7 of the human gene formed a single exon in the rat gene.", "output": {"entities": {"gene": [{"text": "rat AdoMet decarboxylase genes", "start": 39, "end": 69}]}}, "schema": []}
{"input": "Interferon-alpha-induced gene expression: evidence for a selective effect of ouabain on activation of the ISGF3 transcription complex.", "output": {"entities": {"gene": [{"text": "Interferon-alpha", "start": 0, "end": 16}, {"text": "ISGF3 transcription complex", "start": 106, "end": 133}]}}, "schema": []}
{"input": "Moreover, LD50 in mice of RP-170 (4. 3 g/kg on i. v.) was increased to 5. 2 g/kg by oral administration.", "output": {"entities": {}}, "schema": []}
{"input": "Among the few proteins of the eukaryotic nucleolus that have been characterized, four proteins, nucleolin, fibrillarin, SSB1 and NSR1, possess a common structural motif, the GAR domain, which is rich in glycine and arginine residues.", "output": {"entities": {"gene": [{"text": "nucleolin", "start": 96, "end": 105}, {"text": "fibrillarin", "start": 107, "end": 118}, {"text": "SSB1", "start": 120, "end": 124}, {"text": "NSR1", "start": 129, "end": 133}]}}, "schema": []}
{"input": "Thus, this study provides evidence that a novel, ubiquitous factor (HF-1a) and a muscle factor (HF-1b/MEF-2) can form a novel, E-box-independent pathway for muscle-specific expression in ventricular cardiac muscle cells.", "output": {"entities": {"gene": [{"text": "HF-1a", "start": 68, "end": 73}, {"text": "HF-1b", "start": 96, "end": 101}, {"text": "MEF-2", "start": 102, "end": 107}]}}, "schema": []}
{"input": "Mutations in either gene block some crucial late step in assembly of F1, causing the alpha and beta subunits to accumulate in mitochondria as inactive aggregates (Ackerman, S.", "output": {"entities": {"gene": [{"text": "F1", "start": 69, "end": 71}]}}, "schema": []}
{"input": "Expense limits the use of hepatitis B vaccines, but low-dose intradermal immunization has been evaluated as a cost-saving strategy in numerous studies.", "output": {"entities": {}}, "schema": []}
{"input": "Estrogen replacement therapy and risk of breast cancer: results of two meta-analyses.", "output": {"entities": {}}, "schema": []}
{"input": "Switching FDC-P1/MAC cells from growth in M-CSF to GM-CSF caused the selective degradation of c-fms mRNA within 6 h after factor switching.", "output": {"entities": {"gene": [{"text": "M-CSF", "start": 42, "end": 47}, {"text": "GM-CSF", "start": 51, "end": 57}, {"text": "c-fms mRNA", "start": 94, "end": 104}]}}, "schema": []}
{"input": "There was however, no significant difference in the prevalence of chronic respiratory symptoms between animal food workers with positive and negative skin tests to house dust or to fish flour or among those with increased or normal IgE (except for dyspnea).", "output": {"entities": {"gene": [{"text": "IgE", "start": 232, "end": 235}]}}, "schema": []}
{"input": "An unexpected finding was the presence at position-403 to-385 of a putative dioxin responsive element, a sequence found to be responsible for the induction of transcription of the cytochrome P450IA1 gene (CYPIA1) and other genes involved in detoxification/activation of polycyclic aromatic hydrocarbons.", "output": {"entities": {"gene": [{"text": "cytochrome P450IA1 gene", "start": 180, "end": 203}, {"text": "CYPIA1", "start": 205, "end": 211}]}}, "schema": []}
{"input": "Using bovine and murine c-myb clones, no change in the rate of c-myb gene transcription or mRNA stability was detected during the cell cycle.", "output": {"entities": {"gene": [{"text": "bovine and murine c-myb", "start": 6, "end": 29}, {"text": "c-myb gene", "start": 63, "end": 73}]}}, "schema": []}
{"input": "A 13 base-pair oligonucleotide spanning nucleotides + 80 to + 92 of the 5 S RNA gene retained specific and high-affinity binding, although the latter was reduced sixfold relative to longer DNA fragments.", "output": {"entities": {"gene": [{"text": "5 S RNA gene", "start": 72, "end": 84}]}}, "schema": []}
{"input": "Moreover, the reconstitution of eUSF and TFIID-depleted transcription complexes with purified protein fractions demonstrate that not only TFIID but also eUSF essentially participates in complex formation even on H5 promoter mutations lacking the TATA-box.", "output": {"entities": {"gene": [{"text": "eUSF", "start": 32, "end": 36}, {"text": "TFIID", "start": 41, "end": 46}, {"text": "TFIID", "start": 138, "end": 143}, {"text": "eUSF", "start": 153, "end": 157}, {"text": "H5 promoter", "start": 212, "end": 223}]}}, "schema": []}
{"input": "Radiolabelled palmitate was not incorporated into the mutated protein, showing that lipid modification occurs at the Cys-22 residue.", "output": {"entities": {}}, "schema": []}
{"input": "17 volunteer deaf Ss were compared with 18 volunteer hearing Ss on the Stanford Hypnotic Clinical Scale (SHCS) of Morgan and J.", "output": {"entities": {}}, "schema": []}
{"input": "Mature tobacco L12 protein has 44% amino acid identity with ribosomal protein L7/L12 of Escherichia coli.", "output": {"entities": {"gene": [{"text": "Mature tobacco L12 protein", "start": 0, "end": 26}, {"text": "L7", "start": 78, "end": 80}, {"text": "L12", "start": 81, "end": 84}]}}, "schema": []}
{"input": "Nuclear-encoded chloroplast ribosomal protein L12 of Nicotiana tabacum: characterization of mature protein and isolation and sequence analysis of cDNA clones encoding its cytoplasmic precursor.", "output": {"entities": {"gene": [{"text": "Nuclear-encoded chloroplast ribosomal protein L12 of Nicotiana tabacum", "start": 0, "end": 70}]}}, "schema": []}
{"input": "The gene encoding IFN-gamma was previously found to contain an intronic enhancer element that was not tissue-specific in its activity, despite the restricted expression of the intact IFN-gamma-encoding gene.", "output": {"entities": {"gene": [{"text": "IFN-gamma", "start": 18, "end": 27}, {"text": "IFN-gamma-encoding gene", "start": 183, "end": 206}]}}, "schema": []}
{"input": "Molecular cloning of the polypeptide component of the Rel-related human p75 nucleoprotein complex has revealed its identity with the 65-kDa (p65) subunit of NF-kappa B.", "output": {"entities": {"gene": [{"text": "Rel-related human p75 nucleoprotein complex", "start": 54, "end": 97}, {"text": "p65", "start": 141, "end": 144}, {"text": "NF-kappa B", "start": 157, "end": 167}]}}, "schema": []}
{"input": "Of the drugs orally administered, WR-168643 was the best protector with a DMF of 1. 51.", "output": {"entities": {}}, "schema": []}
{"input": "Characterization of these R subunits by their 8-azido-cAMP photoaffinity labeling and immunoreactivity, as well as by a phosphorylation-dependent mobility shift on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), indicated subunit sizes of RII beta (53 kDa) greater than RII alpha dephosphoform (51 kDa) greater than RI alpha (49 kDa).", "output": {"entities": {"gene": [{"text": "RII beta", "start": 261, "end": 269}, {"text": "RII alpha", "start": 292, "end": 301}, {"text": "RI alpha", "start": 338, "end": 346}]}}, "schema": []}
{"input": "Comparison of the genomic DNA sequence with that of the four different mRNAs indicates that these transcripts are produced by alternative splicing of the murine pre-mRNA according to a cassette model.", "output": {"entities": {}}, "schema": []}
{"input": "During the 1980' s, quantifications of immunoserological testings, especially C reactive protein, rheumatoid factor and antistreptolysin O, progressed rapidly.", "output": {"entities": {"gene": [{"text": "C reactive protein", "start": 78, "end": 96}, {"text": "rheumatoid factor", "start": 98, "end": 115}, {"text": "antistreptolysin O", "start": 120, "end": 138}]}}, "schema": []}
{"input": "Within the human enhancer, these two sites are located within the previously defined DNase I footprints, NFAT-1 and NFIL-2B, respectively.", "output": {"entities": {"gene": [{"text": "DNase I footprints", "start": 85, "end": 103}, {"text": "NFAT-1", "start": 105, "end": 111}, {"text": "NFIL-2B", "start": 116, "end": 123}]}}, "schema": []}
{"input": "The cardiac myosin light chain-2 (MLC-2) gene promoter contains several positive and negative cis-acting sequences that are involved in the regulation of its expression.", "output": {"entities": {"gene": [{"text": "cardiac myosin light chain-2", "start": 4, "end": 32}, {"text": "MLC-2", "start": 34, "end": 39}]}}, "schema": []}
{"input": "Deletion mutagenesis demonstrated that these two elements are involved in the positive regulation of MLC-2 gene transcription.", "output": {"entities": {"gene": [{"text": "MLC-2 gene", "start": 101, "end": 111}]}}, "schema": []}
{"input": "Disruption mutations have been constructed in the SLK1 gene. slk1 null mutants cannot grow at 37 degrees C, but many cells can grow at 30, 24, and 17 degrees C.", "output": {"entities": {"gene": [{"text": "SLK1 gene", "start": 50, "end": 59}, {"text": "slk1 null mutants", "start": 61, "end": 78}]}}, "schema": []}
{"input": "Molecular and genetic analysis of the yeast early meiotic recombination genes REC102 and REC107/MER2.", "output": {"entities": {"gene": [{"text": "yeast early meiotic recombination genes REC102", "start": 38, "end": 84}, {"text": "REC107", "start": 89, "end": 95}, {"text": "MER2", "start": 96, "end": 100}]}}, "schema": []}
{"input": "Probable progressive multifocal leukoencephalopathy (PML) was diagnosed on the basis of clinical picture and magnetic resonance imaging in a 63-year-old man with a complete remission of a non-Hodgkin' s lymphoma.", "output": {"entities": {}}, "schema": []}
{"input": "Proprotein processing occurs intracellularly.", "output": {"entities": {}}, "schema": []}
{"input": "A 32P-labeled LAP DNA-binding and dimerization domain \" zipper probe \" was used to isolate a clone that encodes a new C/EBP-homologous protein: CHOP-10.", "output": {"entities": {"gene": [{"text": "LAP", "start": 14, "end": 17}, {"text": "C/EBP-homologous protein", "start": 118, "end": 142}, {"text": "CHOP-10", "start": 144, "end": 151}]}}, "schema": []}
{"input": "Using a degenerate oligodeoxyribonucleotide (oligo) based on the N-terminal aa sequence, plus an internal oligo homologous to a conserved region within the portion of CYP1 and CYP2 that had been deleted in the genome, a CYP3-specific DNA fragment was generated by the polymerase chain reaction (PCR) using GL81 genomic DNA as a substrate.", "output": {"entities": {"gene": [{"text": "CYP1", "start": 167, "end": 171}, {"text": "CYP2", "start": 176, "end": 180}, {"text": "CYP3-specific DNA fragment", "start": 220, "end": 246}]}}, "schema": []}
{"input": "Stringent hybridization of EHS-1 back to primate genomic DNA indicates two distinct EHS-1 loci in normal human DNA, an identical band pattern in chimpanzee DNA, and a single locus in rhesus monkey DNA.", "output": {"entities": {"gene": [{"text": "EHS-1", "start": 27, "end": 32}, {"text": "EHS-1 loci", "start": 84, "end": 94}]}}, "schema": []}
{"input": "The level of carboxyl-terminal parathyroid hormone in the patients with thyroid carcinoma was higher than that in the patients without thyroid carcinoma (P less than 0. 05).", "output": {"entities": {"gene": [{"text": "carboxyl-terminal parathyroid hormone", "start": 13, "end": 50}]}}, "schema": []}
{"input": "The Caenorhabditis elegans vitellogenin genes are subject to sex-, stage-, and tissue-specific regulation: they are expressed solely in the adult hermaphrodite intestine.", "output": {"entities": {"gene": [{"text": "Caenorhabditis elegans vitellogenin genes", "start": 4, "end": 45}]}}, "schema": []}
{"input": "The functions of isolated portions of the insulin, IAPP, and beta GK promoters were studied by using transient expression and DNA binding assays.", "output": {"entities": {"gene": [{"text": "insulin", "start": 42, "end": 49}, {"text": "IAPP", "start": 51, "end": 55}, {"text": "beta GK promoters", "start": 61, "end": 78}]}}, "schema": []}
{"input": "The c-Ets-1 oncoprotein is a transcription activator that specifically binds to DNA.", "output": {"entities": {"gene": [{"text": "c-Ets-1 oncoprotein", "start": 4, "end": 23}]}}, "schema": []}
{"input": "Previous transactivation experiments indicated that three amino acids residing in this region, Gly, Ser and Val, appear to be critical for target-site discrimination.", "output": {"entities": {}}, "schema": []}
{"input": "GR63178A is a water-soluble analogue of mitoquidone, a pentacyclic pyrroloquinone.", "output": {"entities": {}}, "schema": []}
{"input": "Marker rescue analysis has localized ts8 to a 910-bp internal segment of rpoB that encodes the Rif domain.", "output": {"entities": {"gene": [{"text": "ts8", "start": 37, "end": 40}, {"text": "rpoB", "start": 73, "end": 77}, {"text": "Rif domain", "start": 95, "end": 105}]}}, "schema": []}
{"input": "This vector transfected into the yeast Saccharomyces cerevisiae directs expression of a secreted mature protein at levels up to 200 mg of LAPP/liter of culture medium.", "output": {"entities": {}}, "schema": []}
{"input": "Competition analysis by gel mobility shift electrophoresis indicates that this DNA-protein interaction is novel and not related to many transcription factors previously reported.", "output": {"entities": {}}, "schema": []}
{"input": "This DNA motif represents a novel protein-binding sequence.", "output": {"entities": {}}, "schema": []}
{"input": "OBJECTIVE: The study was designed to investigate the frequency of alterations in serum creatinine in patients with psoriasis receiving 5 mg/kg/day of cyclosporine.", "output": {"entities": {}}, "schema": []}
{"input": "Intrapocket chemotherapy in adult periodontitis using a new controlled-release insert containing ofloxacin (PT-01).", "output": {"entities": {}}, "schema": []}
{"input": "Electromagnetic blood flow (BF) probe was applied on the left anterior descending artery (LAD).", "output": {"entities": {}}, "schema": []}
{"input": "Hence temperature and virF are both required for the induction of the yop regulon.", "output": {"entities": {"gene": [{"text": "virF", "start": 22, "end": 26}, {"text": "yop regulon", "start": 70, "end": 81}]}}, "schema": []}
{"input": "Problems remain to be resolved in the area of quantitative risk assessment.", "output": {"entities": {}}, "schema": []}
{"input": "The Klebsiella aerogenes gene maoA, which is involved in the synthesis of monoamine oxidase, was induced by tyramine and the related compounds, subjected to catabolite and ammonium ion repression, and cloned.", "output": {"entities": {"gene": [{"text": "Klebsiella aerogenes gene maoA", "start": 4, "end": 34}, {"text": "monoamine oxidase", "start": 74, "end": 91}]}}, "schema": []}
{"input": "Eight of 14 infectious or inflammatory lesions could be detected in the early scan (4-6 h p. i.).", "output": {"entities": {}}, "schema": []}
{"input": "Similar observations have been made previously for other genes.", "output": {"entities": {}}, "schema": []}
{"input": "Preceptorship of CNS students: an exploratory study.", "output": {"entities": {}}, "schema": []}
{"input": "To determine the genetic basis for the differences between the cardiac and brain AE3 variants, we isolated and characterized the rat gene.", "output": {"entities": {"gene": [{"text": "brain AE3 variants", "start": 75, "end": 93}]}}, "schema": []}
{"input": "The 1. 7 kb cloned fragment was sequenced and shown to contain the entire fliA gene.", "output": {"entities": {"gene": [{"text": "fliA gene", "start": 74, "end": 83}]}}, "schema": []}
{"input": "Institution of both intravenous and intracisternal administration of amphotericin B and possibly concomitant intravenous administration of dexamethasone may be warranted in situations in which the association of C. immitis with CNS vasculitis or encephalitis appears likely before serologic or cultural confirmation of C. immitis infection involving the CNS is available.", "output": {"entities": {}}, "schema": []}
{"input": "Lac operators were introduced into several positions within the CAB promoter and operator-free plasmid was used as control.", "output": {"entities": {"gene": [{"text": "Lac", "start": 0, "end": 3}, {"text": "CAB promoter", "start": 64, "end": 76}]}}, "schema": []}
{"input": "Overproduction, purification and characterization of M. HinfI methyltransferase and its deletion mutant.", "output": {"entities": {"gene": [{"text": "M. HinfI methyltransferase", "start": 53, "end": 79}]}}, "schema": []}
{"input": "Various companies produce this type of lens.", "output": {"entities": {}}, "schema": []}
{"input": "From March 5 through October 26, 1991, eight persons were diagnosed with elevated blood lead levels (BLLs) at a local hospital and were reported to the notifiable disease surveillance system maintained by the Alabama Department of Public Health (ADPH).", "output": {"entities": {}}, "schema": []}
{"input": "According to the changes of perfusion defects between Ex, RD and ReI images, they were classified into 3 types: Type I; perfusion defect on the RD image was identical to ReI image (75%) Type I was divided into 2 subgroups whether perfusion defect at Ex was unchanged (Ia, 42%) or improved (Ib, 33%) on the RD image.", "output": {"entities": {}}, "schema": []}
{"input": "Keck, C. J.", "output": {"entities": {}}, "schema": []}
{"input": "Twenty-eight (7. 0%) infants without periventricular hemorrhage were revealed as having spastic cerebral palsy by neurodevelopmental evaluation in later infancy.", "output": {"entities": {}}, "schema": []}
{"input": "A possible mechanism is that elevated alveolar pressure and decreased cardiac output eliminate blood flow from corner vessels in nondependent high VA/Q regions.", "output": {"entities": {}}, "schema": []}
{"input": "In both cities, HTLV-I/II prevalence increased significantly with age, and the New Orleans age-and sex-adjusted HTLV-I/II prevalence was significantly higher than that of Baltimore (P less than. 001).", "output": {"entities": {}}, "schema": []}
{"input": "Hybridization data indicate that 6F6. 2 corresponds to the previously characterized m6F6 cDNA clone and that 6F6. 1 and 6F6. 3, but not 6F6. 2, are adjacent to alpha-type genes.", "output": {"entities": {"gene": [{"text": "6F6. 2", "start": 33, "end": 39}, {"text": "m6F6 cDNA clone", "start": 84, "end": 99}, {"text": "6F6. 1", "start": 109, "end": 115}, {"text": "6F6. 3", "start": 120, "end": 126}, {"text": "6F6. 2", "start": 136, "end": 142}, {"text": "alpha-type genes", "start": 160, "end": 176}]}}, "schema": []}
{"input": "The SEN1 gene corresponds to a 6, 336-bp open reading frame coding for a 2, 112-amino-acid protein (molecular mass, 239 kDa).", "output": {"entities": {"gene": [{"text": "SEN1 gene", "start": 4, "end": 13}]}}, "schema": []}
{"input": "Protein tyrosine kinases (PTKs) are implicated in the control of cell growth by virtue of their frequent appearance as products of retroviral oncogenes, as intracellular signal transducers, and as growth factor receptors or components thereof.", "output": {"entities": {"gene": [{"text": "Protein tyrosine kinases", "start": 0, "end": 24}, {"text": "PTKs", "start": 26, "end": 30}, {"text": "growth factor receptors", "start": 197, "end": 220}]}}, "schema": []}
{"input": "The IA4 mAb was identified among a series of antibodies raised in BALB/c mice after immunization against a HLA class I-deficient, lymphokine-activated killer (LAK)-susceptible EBV-B lymphocyte line.", "output": {"entities": {"gene": [{"text": "IA4 mAb", "start": 4, "end": 11}, {"text": "HLA", "start": 107, "end": 110}]}}, "schema": []}
{"input": "In a randomized double-blind cross-over study, the subjects received theophylline 5 mg. kg-1 per day with omeprazole 20 mg per day or identical placebo during two periods, each of 7 days, separated by a washout period of 7 days.", "output": {"entities": {}}, "schema": []}
{"input": "Primer extension and mung bean and S1 nuclease mapping indicated multiple transcription initiation sites and were consistent with Northern analyses.", "output": {"entities": {"gene": [{"text": "mung bean and S1 nuclease", "start": 21, "end": 46}]}}, "schema": []}
{"input": "Two variant PRP-precursor alleles occur which slightly differ in the number of repeats in domain C.", "output": {"entities": {"gene": [{"text": "PRP-precursor alleles", "start": 12, "end": 33}]}}, "schema": []}
{"input": "Unlike the typical enhancer element, this region functions in an orientation-dependent manner.", "output": {"entities": {}}, "schema": []}
{"input": "Allagille' s syndrome associated with antenatal ascites", "output": {"entities": {}}, "schema": []}
{"input": "Sensitivity and specificity was established for the Pharmacia CAP System and the DPC AlaSTAT System by comparison with results of the skin prick test.", "output": {"entities": {}}, "schema": []}
{"input": "PSI-G and PSI-K probably have evolved from a gene duplication of an ancestral gene.", "output": {"entities": {"gene": [{"text": "PSI-G", "start": 0, "end": 5}, {"text": "PSI-K", "start": 10, "end": 15}]}}, "schema": []}
{"input": "Site-directed mutagenesis revealed that two clusters of basic amino acids within a conserved basic region and two amphipathic helices within the adjacent HLH domain are essential for sequence-specific DNA binding and hetero-oligomerization, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Dimerization of Myf-5 with the ubiquitously expressed bHLH protein E12 not only increases the affinity for DNA but also stimulates transactivation independently of DNA binding.", "output": {"entities": {"gene": [{"text": "Myf-5", "start": 16, "end": 21}, {"text": "E12", "start": 67, "end": 70}]}}, "schema": []}
{"input": "SEA was recorded with bidirectional filters at 25-250 HZ and 40-250 Hz using Simson method.", "output": {"entities": {}}, "schema": []}
{"input": "Neural-specific expression, genomic structure, and chromosomal localization of the gene encoding the zinc-finger transcription factor NGFI-C.", "output": {"entities": {"gene": [{"text": "zinc-finger transcription factor NGFI-C", "start": 101, "end": 140}]}}, "schema": []}
{"input": "An experiment examined the effects of treatment with gonadotrophin releasing hormone (100 micrograms GnRH injected 24 h after progestagen sponge removal), season of treatment (autumn v. spring), the effect of supplementary feeding with lupin grain (in autumn only, from 12 days before until 8 days after sponge removal) on the time of ovulation in 182 mature Merino ewes superovulated with a combination of 400 I. U. pregnant mare serum gonadotrophin (PMSG) and 12 mg follicle stimulating hormone (FSH-P).", "output": {"entities": {"gene": [{"text": "gonadotrophin releasing hormone", "start": 53, "end": 84}, {"text": "GnRH", "start": 101, "end": 105}, {"text": "pregnant mare serum gonadotrophin", "start": 417, "end": 450}, {"text": "PMSG", "start": 452, "end": 456}, {"text": "follicle stimulating hormone", "start": 468, "end": 496}, {"text": "FSH-P", "start": 498, "end": 503}]}}, "schema": []}
{"input": "Drug-drug interactions are most likely to occur in patients receiving multiple medications and with drugs that have a narrow therapeutic window.", "output": {"entities": {}}, "schema": []}
{"input": "Total body irradiation was delivered according to a hyperfractionated scheme of 12 fractions given three per day 5 hr apart for 4 days.", "output": {"entities": {}}, "schema": []}
{"input": "A reduction in blood pressure was only observed at the end of the study, from 142 +/-17/86. 6 +/-9. 1 to 139 +/-13/82. 9 +/-8. 9 mmHg (P less than 0. 05 for DBP).", "output": {"entities": {}}, "schema": []}
{"input": "A gene homologous to the Escherichia coli dnaA gene was isolated from Pseudomonas putida and its transcription was investigated in E. coli as well as in P. putida.", "output": {"entities": {"gene": [{"text": "Escherichia coli dnaA gene", "start": 25, "end": 51}]}}, "schema": []}
{"input": "STP1 is an unessential yeast gene involved in the removal of intervening sequences from some, but not all, families of intervening sequence-containing pre-tRNAs.", "output": {"entities": {"gene": [{"text": "STP1", "start": 0, "end": 4}]}}, "schema": []}
{"input": "Using these antibodies, we were able to define the conditions to completely solubilize the Cdc25 protein.", "output": {"entities": {"gene": [{"text": "Cdc25 protein", "start": 91, "end": 104}]}}, "schema": []}
{"input": "GCR1 gene function is required for high-level glycolytic gene expression in Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "GCR1 gene", "start": 0, "end": 9}]}}, "schema": []}
{"input": "The decay curves of chlorophyll fluorescence showed a superposition of three exponentially decaying components with time constants of T1 = 100-200 ps, T2 = 300-500 ps and T3 = 2. 0-3. 5 ns.", "output": {"entities": {}}, "schema": []}
{"input": "After tilting, systolic blood pressure fell an average of 17% in patients who cramped infrequently (p = 0. 0031) but only 10% in frequently cramping patients.", "output": {"entities": {}}, "schema": []}
{"input": "Most apneic events occurred during Stages I and II, and REM, but this proportion was less during the gamma OH study (77. 9 +/-8. 9%) than during the control studies (92. 3 +/-1. 9 and 95. 9 +/-2. 2%), apneas occurring even during SWS with gamma OH. (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {}}, "schema": []}
{"input": "Eight rabbits were exposed to 0. 7 +/-0. 4 mg/m3 Co2 + as CoCl2 and 1. 2 +/-0. 7 mg/m3 Cr3 + as Cr (NO3) 3 (group Co + Cr), eight to 0. 6 +/-0. 5 mg/m3 Co2 + (group Co), and eight to filtered air (control group), for 4 months, 5 days/week, and 6 hr/day.", "output": {"entities": {}}, "schema": []}
{"input": "16 women were treated with methadone to prevent withdrawal symptoms.", "output": {"entities": {}}, "schema": []}
{"input": "Disruption demonstrates that CDC14 is an essential gene.", "output": {"entities": {"gene": [{"text": "CDC14", "start": 29, "end": 34}]}}, "schema": []}
{"input": "Coronary flow was reduced by 10% in the phosphocreatine and by 18% in the control group.", "output": {"entities": {}}, "schema": []}
{"input": "The 60A transcripts and protein are first detected at the onset of gastrulation, primarily in the mesoderm of the extending germ band.", "output": {"entities": {"gene": [{"text": "60A transcripts", "start": 4, "end": 19}]}}, "schema": []}
{"input": "Influence of neural regulation on anti-arrhythmic effects of GABA in rats", "output": {"entities": {}}, "schema": []}
{"input": "Recent investigations have detailed a selective dye release technique in which a pulse of laser light induces the release of a fluorescent dye from temperature-sensitive liposomes circulating in the retinal vasculature.", "output": {"entities": {}}, "schema": []}
{"input": "And the natural barriers?", "output": {"entities": {}}, "schema": []}
{"input": "Three pyridoxine derivatives have been isolated from the fresh stem bark of Albizzia julibrissin DURAZZ..", "output": {"entities": {}}, "schema": []}
{"input": "The coating materials were poloxamine 904, poloxamine 908, poloxamine 1508, poloxamer 338, and Brij 35.", "output": {"entities": {}}, "schema": []}
{"input": "The eating and drinking patterns of pygmy goats fed ad lib and kept on a 12 h light/12 h dark cycle were recorded and analyzed.", "output": {"entities": {}}, "schema": []}
{"input": "The present study highlights the improvement in sputum amoxycillin (amoxy) levels when a combination tablet, amoxy 500 mg plus bromhexeine 8 mg, is administered as compared to plain amoxy 500 mg.", "output": {"entities": {}}, "schema": []}
{"input": "His HC II activity and antigen levels were 49% and 50%, respectively, and his daughter also showed similar low levels.", "output": {"entities": {"gene": [{"text": "HC II", "start": 4, "end": 9}]}}, "schema": []}
{"input": "Argatroban may be more effective under low HC II conditions because of its potent inhibition of thrombin activity at sites of vascular wall damage.", "output": {"entities": {"gene": [{"text": "HC II", "start": 43, "end": 48}, {"text": "thrombin", "start": 96, "end": 104}]}}, "schema": []}
{"input": "Because the adrenergic nervous system influences cardiac arrhythmias and myocardial infarction can directly affect sympathetic innervation in the heart, we investigated the role of the sympathetic nervous system on reentry in the canine heart 4 days after infarction.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, no transcripts of the same size and having the same developmental profile as those generated by the wild-type E10 fragment were identified by probes covering the remainder of the cloned region.", "output": {"entities": {"gene": [{"text": "wild-type E10 fragment", "start": 113, "end": 135}]}}, "schema": []}
{"input": "Intravenous amine pressor tests in healthy volunteers.", "output": {"entities": {}}, "schema": []}
{"input": "The mean minimum steady-state concentration after the oral regimen (23 micrograms. l-1) was 78% of that after the intramuscular regime (29 micrograms. l-1).", "output": {"entities": {}}, "schema": []}
{"input": "In an ongoing study the performance of the SMSP is being compared with that of the Mini Speech Processor (MSP).", "output": {"entities": {}}, "schema": []}
{"input": "These mutant proteins retained the ability to competitively inhibit kappa B-mediated transcriptional activation of the human immunodeficiency virus long terminal repeat but failed to efficiently transform chicken lymphoid cells both in vitro and in vivo.", "output": {"entities": {"gene": [{"text": "kappa B", "start": 68, "end": 75}, {"text": "human immunodeficiency virus long terminal repeat", "start": 119, "end": 168}]}}, "schema": []}
{"input": "The sequence-specific interaction of nuclear factor HiNF-D with this key proximal promoter element of the H4-FO108 gene is cell cycle regulated in normal diploid cells (J.", "output": {"entities": {"gene": [{"text": "nuclear factor HiNF-D", "start": 37, "end": 58}, {"text": "H4-FO108 gene", "start": 106, "end": 119}]}}, "schema": []}
{"input": "In conclusion, to study and overcome TI region-based expression problems it is worthwhile to start out with a versatile vector containing exhaustive mutations in the periShine-Dalgarno sequences; as a rule the coding MTI subregion can be kept unchanged.", "output": {"entities": {}}, "schema": []}
{"input": "Four of these five subjects also performed mixed sequences under conditional control of the words (e. g., A1----B2----A3----B4----A5 and its reversal), verifying that the stimuli which occupied the same position in each sequence were members of the same class.", "output": {"entities": {}}, "schema": []}
{"input": "While blood pressure and noradrenergic activity, assessed as changes in the plasma levels and urinary excretion of norepinephrine, remained unaffected in the Pl group, a significant drop in the supine systolic and diastolic blood pressures, as well as in the resting venous norepinephrine level and in urinary norepinephrine excretion was found after the first month of dF administration.", "output": {"entities": {}}, "schema": []}
{"input": "Wild-type protein bound azido-ATP well, but mutants with substitutions in the consensus amino acids were unable to bind azido-ATP.", "output": {"entities": {}}, "schema": []}
{"input": "Therefore, with a biopsy from the stoma site there is a risk of missing early rejection.", "output": {"entities": {}}, "schema": []}
{"input": "Whole blood serotonin levels were investigated in a control group (n = 35) and in a group of chronic renal failure patients (n = 127) on various treatment regimen i. e. conservative treatment (n = 39), maintenance haemodialysis (n = 35) and after renal transplantation (n = 53).", "output": {"entities": {}}, "schema": []}
{"input": "Tissues and exudates contain sufficient thymidine for growth of anaerobic bacteria in the presence of inhibitory levels of trimethoprim-sulfamethoxazole.", "output": {"entities": {}}, "schema": []}
{"input": "The homologies between RAD16, RAD54 and SNF2 are also shared by several additional, recently isolated yeast and Drosophila genes.", "output": {"entities": {"gene": [{"text": "RAD16", "start": 23, "end": 28}, {"text": "RAD54", "start": 30, "end": 35}, {"text": "SNF2", "start": 40, "end": 44}]}}, "schema": []}
{"input": "But the application solutions of instrument disinfectants should not be used longer than one day.", "output": {"entities": {}}, "schema": []}
{"input": "In the Rett syndrome we, therefore, suspect there are disturbances in the brain stem functions especially in the ascending reticular activating system which is related to elevation of the conscious level.", "output": {"entities": {}}, "schema": []}
{"input": "In a similar experiment, simultaneous nitrofurazone administration and S. enteritidis challenge resulted in no significant differences in S. enteritidis isolation frequency.", "output": {"entities": {}}, "schema": []}
{"input": "In agreement with this southern blotting of mouse DNA with SmN probes reveals bands, additional to those derived from the pseudogene, which are characteristic of an intron-containing SmN gene.", "output": {"entities": {"gene": [{"text": "SmN", "start": 59, "end": 62}, {"text": "SmN gene", "start": 183, "end": 191}]}}, "schema": []}
{"input": "Two cDNAs encoding casein kinase-1 have been isolated from a yeast cDNA library and termed CKI1 and CKI2.", "output": {"entities": {"gene": [{"text": "casein kinase-1", "start": 19, "end": 34}, {"text": "CKI1", "start": 91, "end": 95}, {"text": "CKI2", "start": 100, "end": 104}]}}, "schema": []}
{"input": "Incidence rate ranging between 122/100, 000/year and 190/100, 000/year were found (minimum, estimated and raw datasets).", "output": {"entities": {}}, "schema": []}
{"input": "The observed sequence variation disrupts the first ORF in many Y' s while most of the second ORF including the putative helicase region is unaffected.", "output": {"entities": {"gene": [{"text": "Y", "start": 63, "end": 64}, {"text": "helicase region", "start": 120, "end": 135}]}}, "schema": []}
{"input": "The final screening yielded a clone containing a 2 kilobase (kb) insert.", "output": {"entities": {}}, "schema": []}
{"input": "Lesions were made by pressure injection of kainic acid into the SOC through a stereotaxically positioned glass micropipette.", "output": {"entities": {}}, "schema": []}
{"input": "A 38-bp poly (dA-dT) region was found to be a positive regulator of Act1 promoter activity.", "output": {"entities": {"gene": [{"text": "Act1 promoter", "start": 68, "end": 81}]}}, "schema": []}
{"input": "We identified a protein, termed NFIL-1 beta A (NF beta A), that binds to a highly conserved 12-bp DNA sequence (-49 to-38) located upstream of the TATA box motif in both the human and murine IL-1 beta genes.", "output": {"entities": {"gene": [{"text": "NFIL-1 beta A", "start": 32, "end": 45}, {"text": "NF beta A", "start": 47, "end": 56}, {"text": "human and murine IL-1 beta genes", "start": 174, "end": 206}]}}, "schema": []}
{"input": "We tried amphotericin B (AmB), and remission of the tumor was obtained.", "output": {"entities": {}}, "schema": []}
{"input": "Cutis aplasia.", "output": {"entities": {}}, "schema": []}
{"input": "The DRF-2 nuclear protein has characteristics similar to those of the muscle-specific regulatory factor, MEF-2 (Buskin and Hauschka 1989; Gossett et al., 1989).", "output": {"entities": {"gene": [{"text": "DRF-2 nuclear protein", "start": 4, "end": 25}, {"text": "MEF-2", "start": 105, "end": 110}]}}, "schema": []}
{"input": "From the 15-kb clone a 4-kb EcoRI fragment containing the first two exons and 2. 6 kb of the 5' flanking region of the opn gene was sequenced, and the transcriptional start site determined by primer extension analysis and S1 nuclease mapping.", "output": {"entities": {"gene": [{"text": "4-kb EcoRI fragment", "start": 23, "end": 42}, {"text": "opn gene", "start": 119, "end": 127}, {"text": "S1 nuclease", "start": 222, "end": 233}]}}, "schema": []}
{"input": "Cardiovascular risk factors were measured by standardized techniques.", "output": {"entities": {}}, "schema": []}
{"input": "Production costs included feed, non-feed operating, fixed, and replacement stock costs.", "output": {"entities": {}}, "schema": []}
{"input": "We report a patient developing factor VII inhibitor possibly as a reaction to penicillin administration; it gave rise to fatal haemorrhage.", "output": {"entities": {"gene": [{"text": "factor VII inhibitor", "start": 31, "end": 51}]}}, "schema": []}
{"input": "Account was taken of noncellular and nonhuman elements in the smears; they included mucus, Charcot-Layden crystals, pollen grains, vegetal fragments and fungi.", "output": {"entities": {}}, "schema": []}
{"input": "The results indicate that the carbon-perfused areas and MBF in the liver, renal cortex, spleen, and small intestinal serosa (only MBF) increased significantly 5 h after CLP.", "output": {"entities": {}}, "schema": []}
{"input": "Lewis, N.", "output": {"entities": {}}, "schema": []}
{"input": "This accurate and rapid method makes the MLPA test logistically feasible for large-scale screening.", "output": {"entities": {}}, "schema": []}
{"input": "The modalities for using reference values for individual subjects as well as for groups are then discussed and the main points of research which must be faced in the near future regarding reference values are highlighted.", "output": {"entities": {}}, "schema": []}
{"input": "The clinical application of the antibody-targeted Phthalocyanine was performed in 3 patients suffering from an advanced ovarian carcinoma (FIGO III).", "output": {"entities": {}}, "schema": []}
{"input": "We found that lung cancer tissues of positive 67Ga scan expressed TFR, but those of a negative scan did not.", "output": {"entities": {"gene": [{"text": "TFR", "start": 66, "end": 69}]}}, "schema": []}
{"input": "This open reading frame was confirmed the correct one by direct amino-terminal sequence analysis of the overproduced msgB gene product.", "output": {"entities": {"gene": [{"text": "msgB gene product", "start": 117, "end": 134}]}}, "schema": []}
{"input": "In this study, we purified and characterized the recombinant furin from the conditioned medium of these cells.", "output": {"entities": {"gene": [{"text": "recombinant furin", "start": 49, "end": 66}]}}, "schema": []}
{"input": "The virus encodes a 40-kDa protein, tax, that is important for the immortalization of T cells.", "output": {"entities": {"gene": [{"text": "tax", "start": 36, "end": 39}]}}, "schema": []}
{"input": "However, butyrate was at least 2-fold more effective in stimulating CAT activity of fusion genes containing upstream sequences (-834 to-576) than those containing proximal sequences (-456 to-172), suggesting two regions in the PSG1-I gene that mediate the butyrate response.", "output": {"entities": {"gene": [{"text": "CAT", "start": 68, "end": 71}, {"text": "PSG1-I gene", "start": 227, "end": 238}]}}, "schema": []}
{"input": "An examination of the role of the carboxyl terminus in regulating NGFI-B transcriptional activity revealed that, in accordance with other nuclear receptors, mutants lacking portions of the carboxyl terminus had greatly decreased activity.", "output": {"entities": {"gene": [{"text": "NGFI-B", "start": 66, "end": 72}]}}, "schema": []}
{"input": "Altogether these results indicate that the Syn 5 locus segregates from the gene specifying gH, to a region encompassing portions of the TK and UL 24 genes, and that the syn mutation does not affect the expression or activity of TK.", "output": {"entities": {"gene": [{"text": "Syn 5 locus", "start": 43, "end": 54}, {"text": "gH", "start": 91, "end": 93}, {"text": "TK", "start": 136, "end": 138}, {"text": "UL 24 genes", "start": 143, "end": 154}, {"text": "syn mutation", "start": 169, "end": 181}, {"text": "TK", "start": 228, "end": 230}]}}, "schema": []}
{"input": "Nucleoprotein (N) expressed by both recombinant vaccinia virus and TGEV had a relative molecular mass (Mr) of 47, 000 and was susceptible to degradation at the C-terminus yielding discrete breakdown products.", "output": {"entities": {}}, "schema": []}
{"input": "Recently, the 3. 6-kb full-length alpha-GalNAc cDNA sequence was isolated and found to have remarkable nucleotide and predicted amino acid homology (55. 8 and 46. 9%, respectively) with the human alpha-galactosidase A (alpha-Gal A) cDNA.", "output": {"entities": {"gene": [{"text": "3. 6-kb full-length alpha-GalNAc cDNA sequence", "start": 14, "end": 60}, {"text": "human alpha-galactosidase A", "start": 190, "end": 217}, {"text": "alpha-Gal A", "start": 219, "end": 230}]}}, "schema": []}
{"input": "The reason that nitrous oxide does not produce hydroxyl radicals readily might be that the one-electron reduction proceeds through an N2O-intermediate which is energetically very unfavourable: EO (N2O/N2O-) =-1. 1 V.", "output": {"entities": {}}, "schema": []}
{"input": "All mutant JCV T antigens bound to JCV and SV40 origins of DNA replication.", "output": {"entities": {"gene": [{"text": "mutant JCV T antigens", "start": 4, "end": 25}]}}, "schema": []}
{"input": "Since each transcript appears to encode the same protein, this complexity may reflect the need for lineage-specific or differentiation-dependent control of expression.", "output": {"entities": {}}, "schema": []}
{"input": "In patients with limited disease, the survival in the alternating arm was significantly superior to the survival in the CAV arm (P =. 014) or the survival in the PE arm (P =. 023).", "output": {"entities": {}}, "schema": []}
{"input": "We identify the \" M region \" of the muscle-specific Xenopus cardiac actin gene promoter from-282 to-348 as necessary for the embryonic expression of a cardiac actin-beta-globin reporter gene injected into fertilized eggs.", "output": {"entities": {"gene": [{"text": "muscle-specific Xenopus cardiac actin gene promoter", "start": 36, "end": 87}, {"text": "actin", "start": 159, "end": 164}, {"text": "beta-globin", "start": 165, "end": 176}]}}, "schema": []}
{"input": "In addition to the previously identified and characterized attenuator 1 situated 93 nucleotides downstream from the major late transcription start site, a second attenuator, attenuator 2, situated 55 nucleotides downstream from it, has been identified.", "output": {"entities": {"gene": [{"text": "attenuator 1", "start": 59, "end": 71}, {"text": "attenuator 2", "start": 174, "end": 186}]}}, "schema": []}
{"input": "EBNA-2 and the cis-acting CD23 element increased TK-promoted mRNA and did not alter the herpes simplex virus TK promoter transcription start site.", "output": {"entities": {"gene": [{"text": "EBNA-2", "start": 0, "end": 6}, {"text": "CD23 element", "start": 26, "end": 38}, {"text": "TK", "start": 49, "end": 51}, {"text": "herpes simplex virus TK promoter transcription start site", "start": 88, "end": 145}]}}, "schema": []}
{"input": "These experiments delineate a 186-bp, EBNA-2-responsive cell DNA fragment and provide firm evidence that EBNA-2 transactivates transcription of cell genes.", "output": {"entities": {"gene": [{"text": "EBNA-2", "start": 38, "end": 44}, {"text": "EBNA-2", "start": 105, "end": 111}]}}, "schema": []}
{"input": "Plasma vitamin E, total lipids and myeloperoxidase levels during spinal surgery.", "output": {"entities": {"gene": [{"text": "myeloperoxidase", "start": 35, "end": 50}]}}, "schema": []}
{"input": "Transfecting the cloned bovine PBR/IBP cDNA into COS-7 cells resulted in an 11-fold increase in the density of high affinity [3H] PK 11195 binding sites which had only low affinity for Ro5-4864.", "output": {"entities": {"gene": [{"text": "PBR", "start": 31, "end": 34}, {"text": "IBP", "start": 35, "end": 38}]}}, "schema": []}
{"input": "The initial phase of increased vascular permeability in the peritoneal cavity and LTB4 production was dose dependently inhibited by the 5-LO inhibitors phenidone, BW A4C, A63162, and ICI 207 968 but not by dexamethasone or colchicine.", "output": {"entities": {}}, "schema": []}
{"input": "Discrepant results with a latex agglutination test in the assessment of cytomegalovirus antibody status of cardiac transplant donors.", "output": {"entities": {}}, "schema": []}
{"input": "Each mRNA contained five or six internal uridine residues, which were transcribed using a mixture of UTP and thio-UTP.", "output": {"entities": {}}, "schema": []}
{"input": "We have isolated and sequenced two overlapping cDNA fragments which could encode the complete amino acid sequence of rat testis fructose-6-phosphate, 2-kinase: fructose-2, 6-bisphosphatase.", "output": {"entities": {"gene": [{"text": "rat testis fructose-6-phosphate, 2-kinase", "start": 117, "end": 158}, {"text": "fructose-2, 6-bisphosphatase", "start": 160, "end": 188}]}}, "schema": []}
{"input": "We have identified SWI5' s nuclear localization signal (NLS) and show that it can confer cell cycle-dependent nuclear entry to a heterologous protein.", "output": {"entities": {"gene": [{"text": "SWI5", "start": 19, "end": 23}]}}, "schema": []}
{"input": "In contrast to behavioral deviation (the avoidance conditioning lost), the haloperidol intrastriatal microinjections did not affect the DA synaptic level in rostral neostriatum.", "output": {"entities": {}}, "schema": []}
{"input": "In similar transient transfection experiments in HeLa cells, overexpression of the wt human retinoblastoma susceptibility gene product, RB, was found to repress the serum-induced IL-6 (-225 to + 13), c-fos (-711 to + 42), and beta-actin (-3400 to + 912) promoters but not the PRV-induced IL-6 (-110 to + 13) or the serum-induced MHC (-528 to-38) promoters.", "output": {"entities": {"gene": [{"text": "wt human retinoblastoma susceptibility gene product", "start": 83, "end": 134}, {"text": "RB", "start": 136, "end": 138}, {"text": "IL-6", "start": 179, "end": 183}, {"text": "c-fos", "start": 200, "end": 205}, {"text": "beta-actin", "start": 226, "end": 236}, {"text": "IL-6", "start": 288, "end": 292}, {"text": "MHC", "start": 329, "end": 332}]}}, "schema": []}
{"input": "This repression was mediated through binding to the E2 DNA-binding site immediately upstream of the P105 promoter TATA box and could be abrogated by preincubation of the HPV-18 P105 promoter template with the nuclear extract allowing the formation of the preinitiation complex.", "output": {"entities": {"gene": [{"text": "E2 DNA-binding site", "start": 52, "end": 71}, {"text": "P105", "start": 100, "end": 104}, {"text": "HPV-18 P105 promoter", "start": 170, "end": 190}]}}, "schema": []}
{"input": "We did not detect p50 in association with native glucocorticoid receptor in L cells or with the overexpressed glucocorticoid receptor in Chinese hamster ovary cells.", "output": {"entities": {"gene": [{"text": "p50", "start": 18, "end": 21}, {"text": "native glucocorticoid receptor", "start": 42, "end": 72}, {"text": "glucocorticoid receptor", "start": 110, "end": 133}]}}, "schema": []}
{"input": "Two putative 12-O-tetradecanoyl-phorbol-13-acetate (TPA) response elements, that might serve as binding sites for the transcription factor AP-1 and a consensus sequence of a transforming growth factor beta 1 (TGF-beta 1) inhibitory element were found in the promoter region.", "output": {"entities": {"gene": [{"text": "transcription factor AP-1", "start": 118, "end": 143}, {"text": "transforming growth factor beta 1", "start": 174, "end": 207}, {"text": "TGF-beta 1", "start": 209, "end": 219}]}}, "schema": []}
{"input": "TPA and TGF-beta 1 did not markedly affect the activities of the 72-kDa enzyme.", "output": {"entities": {"gene": [{"text": "TGF-beta 1", "start": 8, "end": 18}]}}, "schema": []}
{"input": "They were almost regularly excited by pressure to the ipsilateral cornea or to both corneas at a strength well above the human corneal pain threshold.", "output": {"entities": {}}, "schema": []}
{"input": "Feed intake was not affected by dietary KCl or NaHCO3 supplementation, but average daily gain increased with increased K and tended to be reduced by dietary NaHCO3.", "output": {"entities": {}}, "schema": []}
{"input": "Extraction procedure for the measurement of butyltin compounds in biological tissues using toluene, HBr, and tropolone.", "output": {"entities": {}}, "schema": []}
{"input": "In this study, we have cloned a region that complements the exoenzyme S-deficient phenotype of strain 388 exs1:: Tn1, a chromosomal Tn1 insertional mutation.", "output": {"entities": {"gene": [{"text": "exoenzyme S", "start": 60, "end": 71}, {"text": "exs1", "start": 106, "end": 110}, {"text": "Tn1", "start": 113, "end": 116}, {"text": "chromosomal Tn1 insertional mutation", "start": 120, "end": 156}]}}, "schema": []}
{"input": "Alignment of the amino acid sequences surrounding Tyr-766 with corresponding regions of other FGFRs revealed conserved tyrosine residues in all known members of the FGFR family.", "output": {"entities": {"gene": [{"text": "FGFRs", "start": 94, "end": 99}, {"text": "FGFR family", "start": 165, "end": 176}]}}, "schema": []}
{"input": "The transcription initiation site was determined to occur 66 bp upstream of the initiating Met.", "output": {"entities": {}}, "schema": []}
{"input": "All anti-I and anti-i CA were shown to express VH4 heavy chains, and 14 of 17 CA expressed a previously described VH4 second hypervariable region determinant, termed VH4-HV2a.", "output": {"entities": {"gene": [{"text": "anti-I", "start": 4, "end": 10}, {"text": "anti-i CA", "start": 15, "end": 24}, {"text": "VH4 heavy chains", "start": 47, "end": 63}, {"text": "CA", "start": 78, "end": 80}, {"text": "VH4", "start": 114, "end": 117}, {"text": "VH4-HV2a", "start": 166, "end": 174}]}}, "schema": []}
{"input": "Intron K1 cox1. 2 is not found in S. cerevisiae and appears at an unique location in K. lactis.", "output": {"entities": {"gene": [{"text": "K1 cox1. 2", "start": 7, "end": 17}]}}, "schema": []}
{"input": "We have determined that the mutants define two complementation groups, designated cgs1 + and cgs2 + (continues to grow in stationary).", "output": {"entities": {"gene": [{"text": "cgs1 +", "start": 82, "end": 88}, {"text": "cgs2 +", "start": 93, "end": 99}]}}, "schema": []}
{"input": "The results of induced coexpression were also supported by rapid generation of FeLV recombinants when FeLV-C was used to infect the feline 3201B cell line that constitutively expresses high levels of endogenous FeLV-specific mRNAs.", "output": {"entities": {}}, "schema": []}
{"input": "Recombination between feline leukemia virus subgroup B or C and endogenous env elements alters the in vitro biological activities of the viruses.", "output": {"entities": {"gene": [{"text": "env", "start": 75, "end": 78}]}}, "schema": []}
{"input": "The nucleotide sequences at the 5' and 3' ends of these introns are characteristic of spliced transcripts from eukaryotic protein-encoding genes, with one significant difference; i. e., the 5' end of the LAT intron is GC instead of the consensus sequence GT.", "output": {"entities": {"gene": [{"text": "LAT intron", "start": 204, "end": 214}]}}, "schema": []}
{"input": "At 1, 5, and 9 months after initial isolation of C. kutscheri from the oral cavity, hamsters were euthanatized, and attempts were made to culture C. kutscheri from 13 additional sites.", "output": {"entities": {}}, "schema": []}
{"input": "The strategy has been used to determine 2. 6 kilobases of nucleotide sequence in the Saccharomyces cerevisiae ADE 1 locus.", "output": {"entities": {"gene": [{"text": "Saccharomyces cerevisiae ADE 1 locus", "start": 85, "end": 121}]}}, "schema": []}
{"input": "Two independent promoters as well as 5' untranslated regions regulate Dd ras expression in Dictyostelium.", "output": {"entities": {"gene": [{"text": "Dd ras", "start": 70, "end": 76}]}}, "schema": []}
{"input": "The results suggested that, depending upon the cell type, gene cotransfer using aminoglycoside resistance as a selectable marker may seriously perturb important cellular control mechanisms such as the PKC pathway leading to activation of gene expression.", "output": {"entities": {"gene": [{"text": "PKC", "start": 201, "end": 204}]}}, "schema": []}
{"input": "Therefore, the strD and strE genes could serve as universal probes indicative of the presence of biosynthetic capacity for 6-deoxyhexose moieties.", "output": {"entities": {"gene": [{"text": "strD", "start": 15, "end": 19}, {"text": "strE genes", "start": 24, "end": 34}]}}, "schema": []}
{"input": "The two genes code for polypeptides of 420 amino acids (M. HgiCI) and 345 amino acids (R. HgiCI).", "output": {"entities": {"gene": [{"text": "polypeptides of 420 amino acids (M. HgiCI)", "start": 23, "end": 65}, {"text": "345 amino acids (R. HgiCI)", "start": 70, "end": 96}]}}, "schema": []}
{"input": "Expression of the wt1 gene via transient transfection in COS-1 cells revealed a 52 kDa protein which was immunoprecipitated by both the N-terminal-and C-terminal-specific antisera.", "output": {"entities": {"gene": [{"text": "wt1 gene", "start": 18, "end": 26}]}}, "schema": []}
{"input": "The factor which binds to the TR promoter co-sedimented with SV40 chromosomes extracted late in infection.", "output": {"entities": {"gene": [{"text": "TR promoter", "start": 30, "end": 41}]}}, "schema": []}
{"input": "Temafloxacin 400 mg b. i. d. administered orally for 28 days represents a safe and effective treatment for chronic bacterial prostatitis.", "output": {"entities": {}}, "schema": []}
{"input": "Its neuromuscular effects are similar to a single ED90 dose of vecuronium.", "output": {"entities": {}}, "schema": []}
{"input": "The patient with a prolonged fever caused by dissecting aneurysm of the aorta in whom pleuropneumonia masked the real diseases has been presented.", "output": {"entities": {}}, "schema": []}
{"input": "The resulting clone pKB11, which has a 1369-base pair (bp) cDNA insert, overlapping pCAD142 by 781 bp, was identified by hybridization methods and sequence analysis and found to contain the entire cDNA sequence for the amino end of the CAD polypeptide.", "output": {"entities": {"gene": [{"text": "pKB11", "start": 20, "end": 25}, {"text": "pCAD142", "start": 84, "end": 91}, {"text": "CAD polypeptide", "start": 236, "end": 251}]}}, "schema": []}
{"input": "This conclusion was confirmed by Northern blotting analysis of the 5'-flanking region of CAD gene.", "output": {"entities": {"gene": [{"text": "CAD gene", "start": 89, "end": 97}]}}, "schema": []}
{"input": "We report the isolation of genomic and cDNA clones of the light-independent Sn: bol3 allele.", "output": {"entities": {"gene": [{"text": "Sn: bol3 allele", "start": 76, "end": 91}]}}, "schema": []}
{"input": "Its clearance has been found to be decreased (typically by around 25%, but often by far more) by erythromycin, troleandomycin (triacetyloleandomycin), roxithromycin, enoxacin, ciprofloxacin, pefloxacin, norfloxacin, ofloxacin, fluoroquinolone T-3262, pipemidic acid, cimetidine, etintidine, propranolol, verapamil, diltiazem, nifedipine, furosemide (frusemide), at least some anovulent agents, viloxazine, allopurinol, ticlopidine, idrocilamide, thiabendazole, disulfiram, influenza-and BCG-vaccination, interferon, and caffeine (half-life increase).", "output": {"entities": {"gene": [{"text": "interferon", "start": 504, "end": 514}]}}, "schema": []}
{"input": "We enrolled 253 HIV-antibody positive heroin addicts without HIV-related disease (n = 81) or with persistent generalized lymphadenopathy (n = 172) in a prospective study to evaluate clinical progression to AIDS related complex (ARC) or AIDS and to identify factors of possible prognostic relevance.", "output": {"entities": {"gene": [{"text": "HIV-antibody", "start": 16, "end": 28}]}}, "schema": []}
{"input": "No homology was found between RNA14 and RNA15 or between RNA14 and other proteins contained in data banks.", "output": {"entities": {"gene": [{"text": "RNA14", "start": 30, "end": 35}, {"text": "RNA15", "start": 40, "end": 45}, {"text": "RNA14", "start": 57, "end": 62}]}}, "schema": []}
{"input": "Mutations in the yeast RNA14 and RNA15 genes result in an abnormal mRNA decay rate; sequence analysis reveals an RNA-binding domain in the RNA15 protein.", "output": {"entities": {"gene": [{"text": "yeast RNA14", "start": 17, "end": 28}, {"text": "RNA15 genes", "start": 33, "end": 44}, {"text": "RNA15 protein", "start": 139, "end": 152}]}}, "schema": []}
{"input": "Myocardial infarction in patients with previous bypass surgery.", "output": {"entities": {}}, "schema": []}
{"input": "The most striking difference in the birch NAD (P) H-NR sequence in comparison to NADH-NR sequences was found at the putative pyridine nucleotide binding site.", "output": {"entities": {"gene": [{"text": "birch NAD (P) H-NR sequence", "start": 36, "end": 63}, {"text": "NADH-NR sequences", "start": 81, "end": 98}]}}, "schema": []}
{"input": "A single amino acid difference in the C-terminal region influences dominant negative activity and receptor dimer formation.", "output": {"entities": {}}, "schema": []}
{"input": "The 95% confidence values (2SD) for the change in Ros required to exclude natural variability were 0. 39, 0. 50 and 0. 53 cmH2O l-1 s, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Among 953 infants in 22 neonatal care units studied, 23% (median value, range 0-78) were found to be faecally colonized with one of 21 distinct nosocomial strains of Escherichia coli, Klebsiella or Enterobacter spp.", "output": {"entities": {}}, "schema": []}
{"input": "Biochemical studies revealed the expected loss of ChAT activity in the dorsal and ventral hippocampi of lesioned animals along with elevated levels of norepinephrine (NE) in the dorsal hippocampus of MS/HSI animals. (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {"gene": [{"text": "ChAT", "start": 50, "end": 54}]}}, "schema": []}
{"input": "The localization of this proteoglycan locus in the human genome and the availability of new RFLPs provide the tools for future studies of human diseases where the HSPG2 proteoglycan gene is suspected to be involved.", "output": {"entities": {"gene": [{"text": "HSPG2 proteoglycan gene", "start": 163, "end": 186}]}}, "schema": []}
{"input": "After 2 min of dobutamine injection, or after 20 min of pimobendan injection, the myocardium was removed, and used for determination of the tissue levels of metabolites of energy and carbohydrate metabolism.", "output": {"entities": {}}, "schema": []}
{"input": "During coronary stenosis, on the contrary, intracoronary procaterol at the same dose significantly deteriorated regional myocardial dysfunction without changing LCX flow, global hemodynamics and cardiac lactate metabolism.", "output": {"entities": {}}, "schema": []}
{"input": "Here we present evidence that major IE proteins IE86, IE72, and IE55 are capable of trans-activating the HIV LTR in a T-cell line, HUT-78.", "output": {"entities": {"gene": [{"text": "major IE proteins IE86", "start": 30, "end": 52}, {"text": "IE72", "start": 54, "end": 58}, {"text": "IE55", "start": 64, "end": 68}, {"text": "HIV LTR", "start": 105, "end": 112}]}}, "schema": []}
{"input": "In a country where general HIV prevalence is low, the strategy is cost-effective for location and counselling of unknowingly seropositive individuals.", "output": {"entities": {}}, "schema": []}
{"input": "The cis-acting element mediating glucocorticoid inducibility of the chicken glutamine synthetase gene has been identified.", "output": {"entities": {"gene": [{"text": "chicken glutamine synthetase gene", "start": 68, "end": 101}]}}, "schema": []}
{"input": "However, the increase in biliary excretion did not compensate for the reduced elimination of bretylium and hexylsalicylic acid via the kidney.", "output": {"entities": {}}, "schema": []}
{"input": "Diagnostic value of cerebrospinal fluid immunoglobulin G (IgG) in pediatric neurological diseases.", "output": {"entities": {"gene": [{"text": "cerebrospinal fluid immunoglobulin G", "start": 20, "end": 56}, {"text": "IgG", "start": 58, "end": 61}]}}, "schema": []}
{"input": "Expression of six genes, ipaB, ipaC, invE, invG, invJ, and invK, was apparently regulated by the positive regulator virF.", "output": {"entities": {"gene": [{"text": "ipaB", "start": 25, "end": 29}, {"text": "ipaC", "start": 31, "end": 35}, {"text": "invE", "start": 37, "end": 41}, {"text": "invG", "start": 43, "end": 47}, {"text": "invJ", "start": 49, "end": 53}, {"text": "invK", "start": 59, "end": 63}, {"text": "virF", "start": 116, "end": 120}]}}, "schema": []}
{"input": "Inducible VT was suppressed entirely in one patient.", "output": {"entities": {}}, "schema": []}
{"input": "The presence of the corresponding mature mRNA transcripts (3. 2-3. 5 kilobase pairs (kb] in human fibroblasts was shown by Northern blot hybridization, S1 nuclease protection assay, and the polymerase chain reaction.", "output": {"entities": {"gene": [{"text": "S1 nuclease", "start": 152, "end": 163}]}}, "schema": []}
{"input": "Approximately 50% of the ribosomal DNA (rDNA) units of Drosophila melanogaster are inactivated by two different 28 S RNA ribosomal gene insertions (type I and type II).", "output": {"entities": {"gene": [{"text": "28 S RNA ribosomal gene", "start": 112, "end": 135}]}}, "schema": []}
{"input": "Gap b3 consists of two polypeptide chains (Mr = 110, 000 and 30, 000), which seem to be proteolytic cleavage products connected by disulfide bonds from a precursor protein.", "output": {"entities": {"gene": [{"text": "Gap b3", "start": 0, "end": 6}]}}, "schema": []}
{"input": "However, the rtFc gamma R alpha cDNA clone is complementary to at least two different-sized mRNAs expressed by CRNK-16 cells, contrasting the single Fc gamma R-related mRNA species expressed by human and mouse natural killer cells.", "output": {"entities": {"gene": [{"text": "rtFc gamma R alpha cDNA", "start": 13, "end": 36}, {"text": "Fc gamma R-related mRNA", "start": 149, "end": 172}]}}, "schema": []}
{"input": "Both genes comprise three exons, two introns and an unusually long 3'-untranslated region (3. 2 kilobase pairs), specificying a mRNA of approximately 4. 1 kilobases.", "output": {"entities": {}}, "schema": []}
{"input": "This exon, here named exon 0, contained the entire 5' untranslated region and the N-terminal signal sequence of the polypeptide.", "output": {"entities": {}}, "schema": []}
{"input": "Treatment of human myeloid cell lines HL-60 and U937 with phorbol 12-myristate 13-acetate (PMA) increased within 2 h cellular levels of the RNA hybridizable to LD78 cDNA.", "output": {"entities": {"gene": [{"text": "LD78 cDNA", "start": 160, "end": 169}]}}, "schema": []}
{"input": "A new, flexible fiberoptic ventriculoscope for observation of the ventricles and major cisterns is reported.", "output": {"entities": {}}, "schema": []}
{"input": "Isopenicillin N isomerase (epimerase) has been purified from Streptomyces clavuligerus, and the amino acid sequence of the N-terminus has been determined.", "output": {"entities": {"gene": [{"text": "Isopenicillin N isomerase", "start": 0, "end": 25}, {"text": "epimerase", "start": 27, "end": 36}]}}, "schema": []}
{"input": "Serum IgG was initially elevated in 6 patients.", "output": {"entities": {"gene": [{"text": "IgG", "start": 6, "end": 9}]}}, "schema": []}
{"input": "The patient initially attained complete remission (CR1) with conventional chemotherapy and then relapsed 14 months later.", "output": {"entities": {}}, "schema": []}
{"input": "157 +/-16 mg/dl; NS), glucose levels, and basal (17 +/-4 vs.", "output": {"entities": {}}, "schema": []}
{"input": "Platelet aggregation and metabolic control are not affected by calcium antagonist treatment in type II diabetes mellitus.", "output": {"entities": {}}, "schema": []}
{"input": "Wnt-1 (int-1) is a cellular oncogene often activated by insertion of proviral DNA of the mouse mammary tumor virus.", "output": {"entities": {"gene": [{"text": "Wnt-1", "start": 0, "end": 5}, {"text": "int-1", "start": 7, "end": 12}]}}, "schema": []}
{"input": "Induction of Jurkat leukemic T cells with phorbol 12-myristate 13-acetate and ionomycin did not affect the level of FKBP mRNA.", "output": {"entities": {"gene": [{"text": "FKBP mRNA", "start": 116, "end": 125}]}}, "schema": []}
{"input": "GLUT5 mRNA is expressed at highest levels in small intestine and at much lower levels in kidney, skeletal muscle, and adipose tissue.", "output": {"entities": {"gene": [{"text": "GLUT5 mRNA", "start": 0, "end": 10}]}}, "schema": []}
{"input": "e.", "output": {"entities": {}}, "schema": []}
{"input": "We speculate that these tumors may represent congenital hamartomatous growths.", "output": {"entities": {}}, "schema": []}
{"input": "Identification and characterization of the promoter for the cytotactin gene.", "output": {"entities": {"gene": [{"text": "cytotactin gene", "start": 60, "end": 75}]}}, "schema": []}
{"input": "(1988) J.", "output": {"entities": {}}, "schema": []}
{"input": "These results strongly suggested that similar, if not identical, the CArG box binding proteins interact with the functionally different promoter element in the VLC1, cardiac alpha-actin, and c-fos genes.", "output": {"entities": {"gene": [{"text": "CArG box binding proteins", "start": 69, "end": 94}, {"text": "VLC1", "start": 160, "end": 164}, {"text": "cardiac alpha-actin", "start": 166, "end": 185}, {"text": "c-fos genes", "start": 191, "end": 202}]}}, "schema": []}
{"input": "Polyadenylation of B4 RNA, which occurs very early during maturation, is limited to 150 residues, and it is this number that is required for polysomal recruitment.", "output": {"entities": {"gene": [{"text": "B4 RNA", "start": 19, "end": 25}]}}, "schema": []}
{"input": "Co-existence of these regulatory elements with other elements, such as the AP-2 element or CCAAT box, was also found.", "output": {"entities": {"gene": [{"text": "AP-2 element", "start": 75, "end": 87}]}}, "schema": []}
{"input": "Recently, studies of agents that disrupt collagen synthesis and deposition have yielded several new angiogenesis inhibitors.", "output": {"entities": {"gene": [{"text": "collagen", "start": 41, "end": 49}]}}, "schema": []}
{"input": "Since the 5'-flanking region of this gene is likely involved in hormonal regulation of its expression, we have isolated and partially characterized an avian fatty acid synthase gene.", "output": {"entities": {"gene": [{"text": "fatty acid synthase", "start": 157, "end": 176}]}}, "schema": []}
{"input": "A new set of cDNA clones spanning approximately 3. 2 kb was isolated from a lambda-ZAP goose liver cDNA library using the 5'-most exon-containing fragment of the 5'-most genomic DNA clone.", "output": {"entities": {}}, "schema": []}
{"input": "Northern blotting analysis indicates that expression of the genes corresponding to these clones is confined to pollen tissue.", "output": {"entities": {}}, "schema": []}
{"input": "Whereas cDNA hybridization to genomic DNA blots indicated a small subfamily of G0S19 genes, simple patterns of bands indicated that most cDNAs, including G0S30 cDNA, corresponded to single-copy genes.", "output": {"entities": {"gene": [{"text": "G0S19 genes", "start": 79, "end": 90}, {"text": "G0S30 cDNA", "start": 154, "end": 164}]}}, "schema": []}
{"input": "Lymphoproliferative disorders arising under immunosuppression with FK 506: initial observations in a large transplant population.", "output": {"entities": {}}, "schema": []}
{"input": "The Drosophila suppressor of sable gene encodes a polypeptide with regions similar to those of RNA-binding proteins.", "output": {"entities": {"gene": [{"text": "Drosophila suppressor of sable gene", "start": 4, "end": 39}]}}, "schema": []}
{"input": "2: 121-133, 1988).", "output": {"entities": {}}, "schema": []}
{"input": "Using avidin-biotin complex DNA binding assays, a series of overlapping alpha promoter DNA sequences between-170 to 29 basepairs were tested, but each failed to bind GR, whereas a control GRE avidly bound receptor.", "output": {"entities": {"gene": [{"text": "avidin-biotin", "start": 6, "end": 19}, {"text": "alpha promoter DNA sequences", "start": 72, "end": 100}, {"text": "GR", "start": 166, "end": 168}]}}, "schema": []}
{"input": "Sequence determination of isolated peptides suggested that Asn120 is glycosylated, Asn65 and Asn109 glycosylated in some molecules but not in others, and Asn72 not glycosylated.", "output": {"entities": {}}, "schema": []}
{"input": "The DNA sequence conferring AP-1 activity was located in the proximal promoter region.", "output": {"entities": {"gene": [{"text": "AP-1", "start": 28, "end": 32}]}}, "schema": []}
{"input": "The murine mutation dominant white spotting (W) is in the proto-oncogene, c-kit.", "output": {"entities": {"gene": [{"text": "murine mutation dominant white spotting", "start": 4, "end": 43}, {"text": "W", "start": 45, "end": 46}, {"text": "c-kit", "start": 74, "end": 79}]}}, "schema": []}
{"input": "The proteins differ in the presence or absence of a 21-amino-acid sequence located 24 amino acids C terminal of the translational initiation codon.", "output": {"entities": {}}, "schema": []}
{"input": "Our results also indicate the existence of sequences downstream of-0. 11 kb which can influence the pattern of tissue-specific expression of the HLA-B7 gene and the ability of this gene to respond to gamma interferon.", "output": {"entities": {"gene": [{"text": "HLA-B7 gene", "start": 145, "end": 156}, {"text": "gamma interferon", "start": 200, "end": 216}]}}, "schema": []}
{"input": "The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110.", "output": {"entities": {"gene": [{"text": "SH2", "start": 4, "end": 7}, {"text": "SH3 domains", "start": 12, "end": 23}, {"text": "pp60src", "start": 27, "end": 34}, {"text": "p130", "start": 99, "end": 103}, {"text": "p110", "start": 108, "end": 112}]}}, "schema": []}
{"input": "These clones overlapped and contained the structural gene encoding the complete C5 alpha-chain and 90% of the beta-chain.", "output": {"entities": {"gene": [{"text": "C5 alpha-chain", "start": 80, "end": 94}]}}, "schema": []}
{"input": "The C5 alpha-chain was encoded by 49 kilobases containing 26 exons; the beta-chain was encoded by 29 kilobases containing 16 exons.", "output": {"entities": {"gene": [{"text": "C5 alpha-chain", "start": 4, "end": 18}]}}, "schema": []}
{"input": "Heterozygous mutation in the G + 5 position of intron 33 of the pro-alpha 2 (I) gene (COL1A2) that causes aberrant RNA splicing and lethal osteogenesis imperfecta.", "output": {"entities": {"gene": [{"text": "pro-alpha 2 (I) gene", "start": 64, "end": 84}, {"text": "COL1A2", "start": 86, "end": 92}]}}, "schema": []}
{"input": "The nucleotide sequences of these genes differ at only nine positions, resulting in three amino acid differences.", "output": {"entities": {}}, "schema": []}
{"input": "The protein predicted by the sequence of the human pim-1 proto-oncogene shares extensive homology with known serine/threonine protein kinases, and yet the human Pim-1 enzyme has previously been reported to exhibit protein tyrosine kinase activity both in vitro and in vivo.", "output": {"entities": {"gene": [{"text": "human pim-1 proto-oncogene", "start": 45, "end": 71}, {"text": "serine/threonine protein kinases", "start": 109, "end": 141}, {"text": "human Pim-1 enzyme", "start": 155, "end": 173}, {"text": "protein tyrosine kinase", "start": 214, "end": 237}]}}, "schema": []}
{"input": "A full-length human pim-1 cDNA was subcloned into the bacterial vector pGEX-2T and the Pim-1 protein expressed as a fusion product with bacterial glutathione S-transferase (GST).", "output": {"entities": {"gene": [{"text": "full-length human pim-1 cDNA", "start": 2, "end": 30}, {"text": "Pim-1 protein", "start": 87, "end": 100}, {"text": "bacterial glutathione S-transferase", "start": 136, "end": 171}, {"text": "GST", "start": 173, "end": 176}]}}, "schema": []}
{"input": "The 10 kDa polypeptide was phosphorylated in vitro by incubating wheat etioplast membranes with [gamma 32P] ATP.", "output": {"entities": {}}, "schema": []}
{"input": "Homology with the human protein is only 34% in the tandem repeat domain, mainly showing conservation of serines and threonines, presumed sites of O-linked carbohydrate attachment.", "output": {"entities": {}}, "schema": []}
{"input": "In addition to targeting partially assembled Ti alpha-beta CD3 gamma delta epsilon TCR complexes to the cell surface, CD3 zeta appears to be essential for interleukin-2 production after TCR stimulation with antigen/major histocompatibility complex.", "output": {"entities": {"gene": [{"text": "Ti alpha-beta CD3 gamma delta epsilon TCR complexes", "start": 45, "end": 96}, {"text": "CD3 zeta", "start": 118, "end": 126}, {"text": "interleukin-2", "start": 155, "end": 168}, {"text": "TCR", "start": 186, "end": 189}, {"text": "antigen/major histocompatibility complex", "start": 207, "end": 247}]}}, "schema": []}
{"input": "When desipramine was injected 16 hrs after fluoxetine injection, brain levels of desipramine were no longer elevated.", "output": {"entities": {}}, "schema": []}
{"input": "Opposite effects of CYP1 are observed in aerobic, heme-sufficient cells.", "output": {"entities": {"gene": [{"text": "CYP1", "start": 20, "end": 24}]}}, "schema": []}
{"input": "A segmental analysis of the key regions of HLA-DR1 that control T cell allorecognition was performed by using a series of transfected cell lines expressing the products of recombinant DRB/H-2Eb genes, paired with either DR alpha or H-2E alpha.", "output": {"entities": {"gene": [{"text": "HLA-DR1", "start": 43, "end": 50}, {"text": "DRB", "start": 184, "end": 187}, {"text": "H-2Eb", "start": 188, "end": 193}, {"text": "DR alpha", "start": 220, "end": 228}, {"text": "H-2E alpha", "start": 232, "end": 242}]}}, "schema": []}
{"input": "We characterized cDNA clones specific for the extracellular matrix glycoprotein undulin.", "output": {"entities": {"gene": [{"text": "undulin", "start": 80, "end": 87}]}}, "schema": []}
{"input": "The alpha inhibin promoter containing a mutated CRE was not regulated by forskolin in granulosa cells and did not bind the CREB protein.", "output": {"entities": {"gene": [{"text": "alpha inhibin promoter", "start": 4, "end": 26}, {"text": "CREB protein", "start": 123, "end": 135}]}}, "schema": []}
{"input": "Regulation of the alpha inhibin gene by cyclic adenosine 3', 5'-monophosphate after transfection into rat granulosa cells.", "output": {"entities": {"gene": [{"text": "alpha inhibin gene", "start": 18, "end": 36}]}}, "schema": []}
{"input": "Comparison of the nucleotide sequences between the human and bovine DNA showed that the sequence similarity extended 2400 bp downstream from the coding region.", "output": {"entities": {}}, "schema": []}
{"input": "In patients with osteomyelitis and joint empyema (n = 48) PMN elastase had a sensitivity of 77%, which was only exceeded by that of the unspecific erythrocyte sedimentation rate (sensitivity 89%).", "output": {"entities": {"gene": [{"text": "PMN elastase", "start": 58, "end": 70}]}}, "schema": []}
{"input": "These results indicate that the sulfhydryl group of certain angiotensin converting enzyme inhibitors can potentiate their effect on the endogenous nitrovasodilator EDRF.", "output": {"entities": {"gene": [{"text": "angiotensin converting enzyme", "start": 60, "end": 89}, {"text": "EDRF", "start": 164, "end": 168}]}}, "schema": []}
{"input": "Pharmacokinetics of FK 506 in transplant patients.", "output": {"entities": {}}, "schema": []}
{"input": "A second even more significant match to this E. coli region was found in the retroviral ribonuclease H (RNase H) domain, and corresponds precisely to a region that has been aligned by previous investigators with the E. coli RNase H, suggesting that Pol I helices O and P are homologous to helices A and D of the RNase H crystal structure, respectively.", "output": {"entities": {"gene": [{"text": "retroviral ribonuclease H", "start": 77, "end": 102}, {"text": "RNase H", "start": 104, "end": 111}, {"text": "E. coli RNase H", "start": 216, "end": 231}, {"text": "Pol I", "start": 249, "end": 254}, {"text": "RNase H", "start": 312, "end": 319}]}}, "schema": []}
{"input": "Analysis of the deduced amino acid sequence suggests that CHIP28 protein contains six bilayer-spanning domains, two exofacial potential N-glycosylation sites, and intracellular N and C termini.", "output": {"entities": {"gene": [{"text": "CHIP28 protein", "start": 58, "end": 72}]}}, "schema": []}
{"input": "The qualitative concentrations of HCG had a sensitivity of 37. 5% and a specificity of 100%.", "output": {"entities": {"gene": [{"text": "HCG", "start": 34, "end": 37}]}}, "schema": []}
{"input": "The reduced rate of F absorption and slower rise in plasma F concentration accompanying delayed gastric emptying indicate that passage of F into the small intestine is the major factor in rapid F absorption.", "output": {"entities": {}}, "schema": []}
{"input": "The activity of serum lipase and amylase distinctly increased at 3 h and went up to the maximum at 12 h after injection of Na-Tc.", "output": {"entities": {"gene": [{"text": "serum lipase", "start": 16, "end": 28}, {"text": "amylase", "start": 33, "end": 40}]}}, "schema": []}
{"input": "They were checked for anti-HCV (anti-C100-3) with HCV EIA kit (Abbott Lab., North Chicago, IL).", "output": {"entities": {"gene": [{"text": "anti-HCV", "start": 22, "end": 30}, {"text": "anti-C100-3", "start": 32, "end": 43}]}}, "schema": []}
{"input": "Diltiazem resulted in a significant increase in epicardial diameter (+ 10%; p = 0. 001) and in coronary blood flow (CBF) (+ 30%; p = 0. 0001).", "output": {"entities": {}}, "schema": []}
{"input": "The first transfusion resulted in a platelet increment to 32 Gpt/l (CCI 11).", "output": {"entities": {}}, "schema": []}
{"input": "These risk factors can be divided into 2 groups: local vessel wall-related factors, and local (focal action) systemic factors.", "output": {"entities": {}}, "schema": []}
{"input": "Epidemiology and prevention of hospital infections in the Local Health Unit of Sassari: profile of bacterial resistance and antimicrobial agents of large usage.", "output": {"entities": {}}, "schema": []}
{"input": "PRDII-BF1-derived cDNAs did not result in stimulation of either basal or tat-induced activated gene expression.", "output": {"entities": {"gene": [{"text": "PRDII-BF1-derived cDNAs", "start": 0, "end": 23}, {"text": "tat", "start": 73, "end": 76}]}}, "schema": []}
{"input": "Vaccinia virus (VV) is a potent immunogen, but the nature of VV proteins involved in the activation of the immune response of the host is not yet known.", "output": {"entities": {}}, "schema": []}
{"input": "Max: functional domains and interaction with c-Myc.", "output": {"entities": {"gene": [{"text": "Max", "start": 0, "end": 3}, {"text": "c-Myc", "start": 45, "end": 50}]}}, "schema": []}
{"input": "86: 3199-3203) or G1 to S phase (Reilly, C.", "output": {"entities": {}}, "schema": []}
{"input": "Substitutions introduced at bases surrounding the ICR2 motif yielded levels of pRNA replication that differed, depending on the maintenance of a putative 5' stem-loop structure in the positive strand of the viral genome.", "output": {"entities": {"gene": [{"text": "ICR2 motif", "start": 50, "end": 60}]}}, "schema": []}
{"input": "Zn (II) coordination domain mutants of T4 gene 32 protein.", "output": {"entities": {"gene": [{"text": "gene 32", "start": 42, "end": 49}]}}, "schema": []}
{"input": "Zn (II) coordination domain mutants of T4 gene 32 protein.", "output": {"entities": {"gene": [{"text": "T4 gene 32 protein", "start": 39, "end": 57}]}}, "schema": []}
{"input": "The tissue specificity of gene expression was identical to that described previously for the CaMV 35S domain B enhancer element.", "output": {"entities": {"gene": [{"text": "CaMV 35S domain B enhancer element", "start": 93, "end": 127}]}}, "schema": []}
{"input": "The pathophysiology and clinical management of acute brain injury in infancy and childhood are presented using acute traumatic brain injury as a model.", "output": {"entities": {}}, "schema": []}
{"input": "Transcripts from a second POU-domain gene, Oct-25, were present at low levels in oocytes and early embryos and were dramatically upregulated during early gastrulation.", "output": {"entities": {"gene": [{"text": "POU-domain gene", "start": 26, "end": 41}, {"text": "Oct-25", "start": 43, "end": 49}]}}, "schema": []}
{"input": "The genome of Thogoto virus comprises six segments of single-stranded, negative sense RNA.", "output": {"entities": {}}, "schema": []}
{"input": "These tumors were classified into three broad groups: I, cystadenoma; II, cystadenocarcinoma; and III, adenocarcinoma with mucin production or an associated cyst.", "output": {"entities": {"gene": [{"text": "mucin", "start": 123, "end": 128}]}}, "schema": []}
{"input": "Immunostaining of cells transfected with these constructs revealed that both the myristoylated and nonmyristoylated mutants were localized in nuclei, whereas wild-type PKC alpha was primarily cytoplasmic and perinuclear.", "output": {"entities": {"gene": [{"text": "wild-type PKC alpha", "start": 158, "end": 177}]}}, "schema": []}
{"input": "We have partially sequenced the RAP74 protein from purified HeLa cells, cloned its complementary DNA and shown that its translation product can interact with RAP30 in vitro as well as in vivo.", "output": {"entities": {"gene": [{"text": "RAP74 protein", "start": 32, "end": 45}, {"text": "RAP30", "start": 158, "end": 163}]}}, "schema": []}
{"input": "Effects of thromboxane synthetase inhibition on postburn mesenteric vascular resistance and the rate of bacterial translocation in a chronic porcine model.", "output": {"entities": {"gene": [{"text": "thromboxane synthetase", "start": 11, "end": 33}]}}, "schema": []}
{"input": "The primary pancreatic insult seemed to be unaffected by the treatment, because neither the rise in plasma lipase nor the development of ascites or the extension of the pancreatic necrosis were diminished.", "output": {"entities": {"gene": [{"text": "plasma lipase", "start": 100, "end": 113}]}}, "schema": []}
{"input": "The size of the mutant molecule corresponds to the unprocessed cytoplasmic precursor (pre-super-pro-PrB), as detected in sec61 mutants, when translocation into the endoplasmic reticulum is blocked.", "output": {"entities": {"gene": [{"text": "pre-super-pro-PrB", "start": 86, "end": 103}, {"text": "sec61 mutants", "start": 121, "end": 134}]}}, "schema": []}
{"input": "Thus, the active-site mutation prevents the wild-type processing of the N-glycosylated 73-kDa precursor of PrB to the 41. 5 kDa pro-PrB in the endoplasmic reticulum.", "output": {"entities": {"gene": [{"text": "PrB", "start": 107, "end": 110}, {"text": "41. 5 kDa pro-PrB", "start": 118, "end": 135}]}}, "schema": []}
{"input": "The predicted amino acid sequence exhibited 70% identity to that of Bacillus stearothermophilus TyrTS and 55% identity to that of E. coli TyrTS, while identity to a second cryptic B. subtilis TyrTS gene, designated tyrZ, was only 27%.", "output": {"entities": {"gene": [{"text": "Bacillus stearothermophilus TyrTS", "start": 68, "end": 101}, {"text": "E. coli TyrTS", "start": 130, "end": 143}, {"text": "B. subtilis TyrTS gene", "start": 180, "end": 202}, {"text": "tyrZ", "start": 215, "end": 219}]}}, "schema": []}
{"input": "Heat-inducible CAT activity was detectable when additional sequences from the native promoter containing three CCAAT boxes and a single HSE were present in the constructions.", "output": {"entities": {"gene": [{"text": "CAT", "start": 15, "end": 18}]}}, "schema": []}
{"input": "SETTING--Women, Infants, and Children clinics in Minneapolis, Minn.", "output": {"entities": {}}, "schema": []}
{"input": "BACKGROUND: The effectiveness of monoamine oxidase inhibitors (MAOIs) in tricyclic resistant depression has received surprisingly little systematic study.", "output": {"entities": {"gene": [{"text": "monoamine oxidase", "start": 33, "end": 50}]}}, "schema": []}
{"input": "The upstream delta-alpha breakpoint is flanked by the direct repeats of the acceptor splice site, whereas the down-stream alpha-delta breakpoint is located in the adjacent intron.", "output": {"entities": {}}, "schema": []}
{"input": "Patients with moderate PDDAT were impaired on all serial positions for both spatial order and spatial recognition memory.", "output": {"entities": {}}, "schema": []}
{"input": "Bone and bones.", "output": {"entities": {}}, "schema": []}
{"input": "Management often involves beta-and calcium channel blocking drugs or type IC antiarrhythmic drugs.", "output": {"entities": {}}, "schema": []}
{"input": "To overcome this problem, we have overexpressed Kex2p using the baculovirus/insect cell expression system.", "output": {"entities": {"gene": [{"text": "Kex2p", "start": 48, "end": 53}]}}, "schema": []}
{"input": "J.", "output": {"entities": {}}, "schema": []}
{"input": "The major 49-kDa core protein in the liver HSPG preparation was found to be reactive to an antibody that specifically recognizes the cytoplasmic domain of fibroglycan.", "output": {"entities": {"gene": [{"text": "major 49-kDa core protein", "start": 4, "end": 29}, {"text": "HSPG", "start": 43, "end": 47}, {"text": "fibroglycan", "start": 155, "end": 166}]}}, "schema": []}
{"input": "While no obvious transmembrane regions were identified, several short hydrophobic amino acid stretches were found to be localized in and around the Pro II region, and these may be responsible for attachment of precursors to membranes.", "output": {"entities": {}}, "schema": []}
{"input": "Toxicity was mild, mainly consisting of emesis (81% of the patients; 66% of the courses), leukopenia of World Health Organization (WHO) grade 1 to 2 (47% of the patients; 18% of the courses), and thrombocytopenia (12% of the patients; 3% of the courses).", "output": {"entities": {}}, "schema": []}
{"input": "This study confirms, although individual reaction is remarkably different, transportation as a potent stressor for Beagle dogs.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: Plasma AVP responses to osmotic stimulation, and non-osmotic inhibition by drinking, were normal in patients with compulsive water drinking.", "output": {"entities": {"gene": [{"text": "Plasma AVP", "start": 9, "end": 19}]}}, "schema": []}
{"input": "The fragments of each region were amplified by polymerase chain reaction and analyzed by gel electrophoresis to detect single-strand conformation polymorphism.", "output": {"entities": {}}, "schema": []}
{"input": "The csbA fusion was maximally expressed during early stationary phase in cells grown in Luria broth containing 5% glucose and 0. 2% glutamine.", "output": {"entities": {"gene": [{"text": "csbA fusion", "start": 4, "end": 15}]}}, "schema": []}
{"input": "The constraints of primase recognition sequences, nucleotide substrate requirements, and the effects of additional proteins on oligoribonucleotide synthesis by the 63-kDa gene 4 protein have been examined using templates of defined sequence.", "output": {"entities": {"gene": [{"text": "primase recognition sequences", "start": 19, "end": 48}, {"text": "63-kDa gene 4 protein", "start": 164, "end": 185}]}}, "schema": []}
{"input": "Thrombolytic therapy in spontaneous coronary artery dissection.", "output": {"entities": {}}, "schema": []}
{"input": "A prospective trial was carried out in 156 unselected patients (41 men, mean age 67. 5 years, 115 women, mean age 71. 4 years) who had undergone total hip joint replacement because of degenerative or inflammatory arthritis or fracture of the neck of the femur.", "output": {"entities": {}}, "schema": []}
{"input": "When both lesions were complete lateral hemisections in weanling operates, little behavioral recovery was observed, similar to complete spinal cord transection (N = 3).", "output": {"entities": {}}, "schema": []}
{"input": "Human SRF-related proteins: DNA-binding properties and potential regulatory targets.", "output": {"entities": {"gene": [{"text": "SRF-related proteins", "start": 6, "end": 26}]}}, "schema": []}
{"input": "We have isolated cDNAs for a gene coding for a G protein alpha subunit from tomato (Lycopersicon esculentum, cv.", "output": {"entities": {"gene": [{"text": "G protein alpha subunit from tomato", "start": 47, "end": 82}]}}, "schema": []}
{"input": "Growth factor stimulation of cells causes the phosphorylation of the c-Myc transcriptional activation domain at Ser62 within a proline-rich region that is highly conserved among members of the Myc family (Alvarez, E., Northwood, I. C., Gonzalez, F.", "output": {"entities": {"gene": [{"text": "c-Myc transcriptional activation domain", "start": 69, "end": 108}, {"text": "Myc family", "start": 193, "end": 203}]}}, "schema": []}
{"input": "The authors evaluated the potential for thrombotic complications arising from implantation of a ventricular assist device (Sarns/3M-VAD) in four calves.", "output": {"entities": {}}, "schema": []}
{"input": "Cardiac output (CO) was significantly higher (p less than 0. 0005) in the MBBF group.", "output": {"entities": {}}, "schema": []}
{"input": "Amino acid residues 147-167 of the previously reported sequence are replaced by new residues 147 to 150.", "output": {"entities": {}}, "schema": []}
{"input": "Transcriptional activation by the HIV-1 Tat protein requires specific residues in the hexanucleotide loop and trinucleotide bulge of the TAR RNA stem-loop structure found in the 5'-untranslated leader of all viral transcripts.", "output": {"entities": {"gene": [{"text": "HIV-1 Tat protein", "start": 34, "end": 51}, {"text": "TAR", "start": 137, "end": 140}]}}, "schema": []}
{"input": "These results strongly suggest that locally-applied TTC in combination with FDBA enhances new bone formation in experimental alveolar bone defects.", "output": {"entities": {}}, "schema": []}
{"input": "As an initial step towards the characterization of replicative DNA polymerases of trypanosomes, we have cloned, sequenced and examined the expression of the Trypanosoma (Trypanozoon) brucei brucei gene that encodes the DNA polymerase alpha catalytic core (pol alpha).", "output": {"entities": {"gene": [{"text": "DNA polymerases of trypanosomes", "start": 63, "end": 94}, {"text": "DNA polymerase alpha catalytic core", "start": 219, "end": 254}, {"text": "pol alpha", "start": 256, "end": 265}]}}, "schema": []}
{"input": "In addition, there was a significant increase in postdexamethasone cortical concentrations with age (p less than 0. 01; r = 0. 31).", "output": {"entities": {}}, "schema": []}
{"input": "The volume fraction (Vv) and number/mm2 (Na) of all capillaries (perfused and nonperfused) in a given area of brain were determined after staining for alkaline phosphatase.", "output": {"entities": {"gene": [{"text": "alkaline phosphatase", "start": 151, "end": 171}]}}, "schema": []}
{"input": "Airway pressure and air flow were measured at the endotracheal tube in 13 children on a variety of ventilators.", "output": {"entities": {}}, "schema": []}
{"input": "Appl.", "output": {"entities": {}}, "schema": []}
{"input": "Issues of distribution of kinetic energy of traumatizing object in direct contact interaction with head during impact are discussed from position of biomechanics.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSION: Monitoring SpO2 at the nasal septum site is more reliable than monitoring it at the finger site in hypothermic patients.", "output": {"entities": {}}, "schema": []}
{"input": "The granules grew as the melted material immersed into the void space among the adhered particles.", "output": {"entities": {}}, "schema": []}
{"input": "Hence, the uPA promoter contains multiple weak cis-acting elements distributed over 7. 0 kb 5' to the translation start site.", "output": {"entities": {"gene": [{"text": "uPA promoter", "start": 11, "end": 23}]}}, "schema": []}
{"input": "Substituting a Ser for Gly69 or a Glu for Lys 71 in the conserved TGEK tetrapeptide in finger II of TFIIIA resulted in the loss of DNA binding.", "output": {"entities": {"gene": [{"text": "TGEK tetrapeptide", "start": 66, "end": 83}, {"text": "TFIIIA", "start": 100, "end": 106}]}}, "schema": []}
{"input": "P.", "output": {"entities": {}}, "schema": []}
{"input": "In one, exploratory behavior (assessed by hole pokes) and locomotion were assessed during a 10-min test session.", "output": {"entities": {}}, "schema": []}
{"input": "12-O-Tetradecanoylphorbol 13-acetate was found to inhibit rapidly and potently the expression of mRNAs coding for the myogenic regulators CMD1 and myogenin.", "output": {"entities": {"gene": [{"text": "CMD1", "start": 138, "end": 142}, {"text": "myogenin", "start": 147, "end": 155}]}}, "schema": []}
{"input": "In Xenopus laevis, the gene encoding the elongation factor 1-alpha variant EF-1 alpha O, where O stands for oocyte, is expressed in oocytes and early embryos.", "output": {"entities": {"gene": [{"text": "elongation factor 1-alpha variant EF-1 alpha O", "start": 41, "end": 87}]}}, "schema": []}
{"input": "These introns belong to the class of nuclear pre-mRNA introns and contain typical 5'-and 3'-consensus sequences, as well as unique features.", "output": {"entities": {}}, "schema": []}
{"input": "The mRNA identified in both human and rat cells with the human clathrin clone revealed transcripts of approximately 6. 5 kb, which is consistent with the predicted 180 kDa molecular weight of the clathrin heavy chain.", "output": {"entities": {"gene": [{"text": "human clathrin", "start": 57, "end": 71}, {"text": "clathrin heavy chain", "start": 196, "end": 216}]}}, "schema": []}
{"input": "In this report, almost 6 kb of DNA sequence is presented, including 1251 bp 5' to the gene, over 4 kb of exon and exon-intron junctions, and 583 bp 3' to the gene.", "output": {"entities": {}}, "schema": []}
{"input": "Antibodies specific to rE12 and rNFIL-6 disrupt nucleoprotein complexes with these DNA-binding sites, confirming the interaction of native in vivo factors.", "output": {"entities": {"gene": [{"text": "rE12", "start": 23, "end": 27}, {"text": "rNFIL-6", "start": 32, "end": 39}]}}, "schema": []}
{"input": "A method is described for detecting targeted events at the mu heavy chain gene which relies on co-conversion (or co-exchange) of a point mutation with a selectable marker contained on a replacement vector.", "output": {"entities": {"gene": [{"text": "mu heavy chain gene", "start": 59, "end": 78}]}}, "schema": []}
{"input": "Allergenic activity of allergen extract Ambrosia elatior (AE) was tested in fifteen volunteers extremely sensitive to the allergen.", "output": {"entities": {}}, "schema": []}
{"input": "This study was aimed at assessing whether c-DDP administration immediately before radiotherapy could increase frequency and duration of objective responses, as well as survival, in patients affected with locally advanced stages of squamous carcinomas of the head and neck.", "output": {"entities": {}}, "schema": []}
{"input": "Two potential regulatory sequences for DNA binding proteins were found in the non-coding 5' region: a HAP2/HAP3 consensus recognition sequence at nucleotide-154 and a BAF1 consensus recognition sequence at nucleotide-136.", "output": {"entities": {"gene": [{"text": "HAP2", "start": 102, "end": 106}, {"text": "HAP3", "start": 107, "end": 111}, {"text": "BAF1 consensus recognition sequence", "start": 167, "end": 202}]}}, "schema": []}
{"input": "We exploit the properties of LexA fusion proteins to study the dimerization and DNA-contacting domains of cRel.", "output": {"entities": {"gene": [{"text": "LexA fusion proteins", "start": 29, "end": 49}, {"text": "cRel", "start": 106, "end": 110}]}}, "schema": []}
{"input": "Plasma lipid and lipoprotein profiles were compared in elderly female runners (RU: n = 15, aged 66 +/-5 years, body fat 20 +/-4%, training distance 35 +/-15 km week-1, VO2max 36 +/-4 ml kg-1 min-1, mean +/-SD) and age-matched untrained women (UT: n = 28, 66 +/-4 years, body fat 26 +/-6%, VO2max 26 +/-3 ml kg-1 min-1).", "output": {"entities": {}}, "schema": []}
{"input": "Fundamental and clinical evaluation of equilibrium dialysis--radioimmunoassay system for measurement of serum free thyroxine", "output": {"entities": {}}, "schema": []}
{"input": "We conclude that TA caused a specific decrease in AGD on GD 20 that was largely reversed by PCD 23.", "output": {"entities": {}}, "schema": []}
{"input": "When examined as adults (8 weeks old), the external genitalia of TA-exposed offspring were normal.", "output": {"entities": {}}, "schema": []}
{"input": "After PTCA, ejection fraction increased from 54 +/-8% to 59 +/-8% (p less than 0. 05) and regional function improved significantly (maximal standard deviation before PTCA: 2. 8 +/-0. 8; after PTCA: 1. 9 +/-0. 9-segments below the first standard deviation before PTCA: 31 +/-16; after PTCA: 19 +/-17).", "output": {"entities": {}}, "schema": []}
{"input": "The alcoholic patient, his work and the subjectivity of the period", "output": {"entities": {}}, "schema": []}
{"input": "These data suggest that the combined treatment with a thromboxane synthetase inhibitor and a thromboxane receptor antagonist provides a better protection against digoxin intoxication than with either agent alone.", "output": {"entities": {"gene": [{"text": "thromboxane synthetase", "start": 54, "end": 76}, {"text": "thromboxane receptor", "start": 93, "end": 113}]}}, "schema": []}
{"input": "A 330-kb YAC, A148A7, spanned from the HLA-DQA1 locus through the Y3/Ring 4 locus and extended at least 130 kb centromeric of YAC B1D12.", "output": {"entities": {"gene": [{"text": "HLA", "start": 39, "end": 42}, {"text": "DQA1", "start": 43, "end": 47}, {"text": "Y3", "start": 66, "end": 68}, {"text": "Ring 4", "start": 69, "end": 75}]}}, "schema": []}
{"input": "Adverse foetal outcome in specific IgM positive Chlamydia trachomatis infection in pregnancy.", "output": {"entities": {"gene": [{"text": "IgM", "start": 35, "end": 38}]}}, "schema": []}
{"input": "Using an image-processing computer, regional LV time-density curves were constructed for one cardiac cycle.", "output": {"entities": {}}, "schema": []}
{"input": "In a second patient the VT became nonsustained.", "output": {"entities": {}}, "schema": []}
{"input": "The possible mechanisms underlying differences in post-tetanic effects from muscle and cutaneous afferents in adults and neonates are discussed.", "output": {"entities": {}}, "schema": []}
{"input": "We examined behavioral alterations in the brown cockroach, Periplaneta brunnea, infected with the acanthocephalan, Moniliformis moniliformis.", "output": {"entities": {}}, "schema": []}
{"input": "First, the finding of a monomeric Alu family repeat at the junction between nonhomology block I and homology block Y of the alpha 2 gene-containing unit in rhesus macaque suggests that the dimeric Alu family repeat, Alu 3, at the orthologous position in human was generated by insertion of a monomeric Alu family repeat into the 3' end of another preexisting Alu family repeat.", "output": {"entities": {"gene": [{"text": "Alu", "start": 34, "end": 37}, {"text": "alpha 2 gene-containing unit in rhesus macaque", "start": 124, "end": 170}, {"text": "Alu", "start": 197, "end": 200}, {"text": "Alu 3", "start": 216, "end": 221}, {"text": "Alu", "start": 302, "end": 305}, {"text": "Alu", "start": 359, "end": 362}]}}, "schema": []}
{"input": "The sequence of the repressor locus, c, of the Streptomyces temperate phage, phi C31, was shown previously to contain an open reading frame encoding a 74 kDa protein.", "output": {"entities": {}}, "schema": []}
{"input": "This differential sensitivity to DB, as measured by a lower concentration of DB which caused loss of righting in LS, was accompanied by an equal rate of water-soluble barbiturate brain distribution and elimination in the two lines.", "output": {"entities": {}}, "schema": []}
{"input": "The existence of threshold concentrations, above which certain phenomena may occur, strengthens the role of sentinels.", "output": {"entities": {}}, "schema": []}
{"input": "However, it was synthesized at both temperatures after addition of A23187.", "output": {"entities": {}}, "schema": []}
{"input": "Ten out of 10 patients with progressive disease had mast cells greater than or equal to 0. 5%, hyaluronan greater than or equal to 50 micrograms. l-1 and fibronectin greater than or equal to 350 micrograms. l-1 compared to eight out of 41 patients with stable or regressive disease. (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {"gene": [{"text": "fibronectin", "start": 154, "end": 165}]}}, "schema": []}
{"input": "Our mapping results did not suggest involvement of this gene in previously mapped genetic disorders or in known neoplasia-associated translocation breakpoints.", "output": {"entities": {}}, "schema": []}
{"input": "These changes weren' t so significant in the group of obese children who didn' t lose weight.", "output": {"entities": {}}, "schema": []}
{"input": "Arsenic contents in native copper", "output": {"entities": {}}, "schema": []}
{"input": "In ten other experiments (5 experimental and 5 control rats) 99mTc-sulfur colloid was injected intravenously.", "output": {"entities": {}}, "schema": []}
{"input": "Magnetotherapy of hepatitis A and B in children", "output": {"entities": {}}, "schema": []}
{"input": "These results were superior to those in 24 patients with conventional end-to-end sutures on clinical testing.", "output": {"entities": {}}, "schema": []}
{"input": "Mutational analysis supports a role for multiple structural features in the C-terminal secretion signal of Escherichia coli haemolysin.", "output": {"entities": {"gene": [{"text": "Escherichia coli haemolysin", "start": 107, "end": 134}]}}, "schema": []}
{"input": "Among blood donors in the Republic of Serbia, regardless the number of blood donations, the percentage of female donors is significantly lower compared to the percentage of male blood donors.", "output": {"entities": {}}, "schema": []}
{"input": "Extramedullary relapse in childhood leukemia.", "output": {"entities": {}}, "schema": []}
{"input": "Mycoplasma pneumoniae was isolated from the pleural fluid of this patient.", "output": {"entities": {}}, "schema": []}
{"input": "RU486 and ONO 802 in combination have been shown to be effective in early termination of pregnancy.", "output": {"entities": {}}, "schema": []}
{"input": "The presence of local abnormalities in both patients can support the hypothesis that the cortex, especially of the temporal anterior lobe, is involved in the origin of the laughing seizures.", "output": {"entities": {}}, "schema": []}
{"input": "In line with the small values for QS/QC, our results further indicate that even large, well-perfused, occluded air spaces in the lung will hardly affect the recovered ventilation/perfusion distribution obtained from inert gas data when CDCSF6 exceeds 0. 1 ml. min-1. mmHg-1.", "output": {"entities": {}}, "schema": []}
{"input": "Many cells were negative for endothelial-cell markers, and they reacted with a monoclonal antibody against muscle actin.", "output": {"entities": {"gene": [{"text": "actin", "start": 114, "end": 119}]}}, "schema": []}
{"input": "CT abnormalities noted in term babies included hemorrhage (subarachnoid 5. 8%, intracerebral 11. 6%), hypodensity (mild 23. 2%, moderate 11. 6% severe 5. 8%); hypodensity with hemorrhage 5. 8% and cerebral atrophy 5. 8%.", "output": {"entities": {}}, "schema": []}
{"input": "The effects of contrast media on coagulation factor XII.", "output": {"entities": {"gene": [{"text": "coagulation factor XII", "start": 33, "end": 55}]}}, "schema": []}
{"input": "Pigs were switched from the growing to the finishing diet at 57 and 61 kg in Exp.", "output": {"entities": {}}, "schema": []}
{"input": "In sixteen patients with moderate essential hypertension the effects of 10-day nifedipine treatment on serum uric acid and renal excretion of uric acid were evaluated.", "output": {"entities": {}}, "schema": []}
{"input": "TPTA produced brain congestion, and hepatic and pulmonary petechial and generalized hemorrhages.", "output": {"entities": {}}, "schema": []}
{"input": "Examples are using more subjects or an improved research design, developing consensus statements or using meta-analysis.", "output": {"entities": {}}, "schema": []}
{"input": "A two phase slug flow tubular heat exchanger was used for the thermal inactivation of Listeria monocytogenes in natural infected milk from seven cows.", "output": {"entities": {}}, "schema": []}
{"input": "So far 15 children have been studied.", "output": {"entities": {}}, "schema": []}
{"input": "Regional cerebral blood flow (rCBF) measurements and psychiatric ratings were performed on seven schizophrenic patients (mean age = 41. 4 years) who had been examined 18 years previously in a study that used similar psychiatric ratings and a comparable rCBF technique.", "output": {"entities": {}}, "schema": []}
{"input": "In the present study, we identified a strong positive cis-regulatory element at-70 bp to-75 bp in the LpS1 beta promoter with the sequence (G) 6 and a similar, more distal cis-element at-721 bp to-726 bp.", "output": {"entities": {"gene": [{"text": "LpS1 beta promoter", "start": 102, "end": 120}]}}, "schema": []}
{"input": "No case of SMF demonstrated expansive tumorous growth.", "output": {"entities": {}}, "schema": []}
{"input": "Different doses of 15-methyl-PGF2 alpha (0. 125-10 mg) were used to induce luteolysis and oestrus in 7 heifers with 28 treatments on day 8-12 of the oestrous cycle.", "output": {"entities": {}}, "schema": []}
{"input": "Review of the literature and report of a case of a dermoid cyst.", "output": {"entities": {}}, "schema": []}
{"input": "Resolution of thermographic asymmetry and/or decrease in Delta T was demonstrated in approximately 81% of the post-treatment population.", "output": {"entities": {}}, "schema": []}
{"input": "Maize rbcS promoter activity depends on sequence elements not found in dicot rbcS promoters.", "output": {"entities": {"gene": [{"text": "Maize rbcS promoter", "start": 0, "end": 19}, {"text": "dicot rbcS promoters", "start": 71, "end": 91}]}}, "schema": []}
{"input": "Measurements were done with a commercial haematofluorometer Buchler ZF which was calibrated to the average haematocrit value of 0. 42.", "output": {"entities": {}}, "schema": []}
{"input": "The relatively scanty number of examples, which could be justified by the variety and complexity of combined exposure, allows to conclude that life-style factors have considerable influence on interindividual differences in susceptibility to xenobiotics toxicity.", "output": {"entities": {}}, "schema": []}
{"input": "The 12S E1A product does not activate a TRE sequence, but cotransfection with c-jun circumvents this lack of stimulation.", "output": {"entities": {"gene": [{"text": "12S E1A product", "start": 4, "end": 19}, {"text": "c-jun", "start": 78, "end": 83}]}}, "schema": []}
{"input": "After treatment with tunicamycin, the transfectants secreted unglycosylated 18-kDa polypeptides which could also bind IgE.", "output": {"entities": {"gene": [{"text": "IgE", "start": 118, "end": 121}]}}, "schema": []}
{"input": "PAS1, a yeast gene required for peroxisome biogenesis, encodes a member of a novel family of putative ATPases.", "output": {"entities": {"gene": [{"text": "PAS1", "start": 0, "end": 4}, {"text": "ATPases", "start": 102, "end": 109}]}}, "schema": []}
{"input": "The pp90rsk-protein kinase activity (referred to as rsk-kinase) is also not related to cofactor-dependent signal transducing protein kinases such as the cyclic AMP-dependent protein kinases, members of the protein kinase C family, or other Ca2 (+)-dependent protein kinases.", "output": {"entities": {"gene": [{"text": "pp90rsk-protein kinase", "start": 4, "end": 26}, {"text": "rsk-kinase", "start": 52, "end": 62}, {"text": "cyclic AMP-dependent protein kinases", "start": 153, "end": 189}, {"text": "protein kinase C family", "start": 206, "end": 229}, {"text": "Ca2 (+)-dependent protein kinases", "start": 240, "end": 273}]}}, "schema": []}
{"input": "Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.", "output": {"entities": {"gene": [{"text": "Human GATA-3", "start": 0, "end": 12}, {"text": "T cell receptor alpha gene", "start": 93, "end": 119}]}}, "schema": []}
{"input": "Like many eukaryotic transcription factors, these proteins bind to DNA as dimers.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, the UvrA protein interacts with the UvrB protein to modulate its activities, both in solution and in association with DNA, where the UvrAB complex possesses a helicase activity.", "output": {"entities": {"gene": [{"text": "UvrA protein", "start": 17, "end": 29}, {"text": "UvrB protein", "start": 49, "end": 61}, {"text": "UvrAB complex", "start": 146, "end": 159}, {"text": "helicase", "start": 172, "end": 180}]}}, "schema": []}
{"input": "The ED30 values were 2. 4 and 2. 2 mg/kg and similar to the respective values of nifedipine (ED 30: 2. 4, 2. 1 mg/kg).", "output": {"entities": {}}, "schema": []}
{"input": "Southwestern blot analysis demonstrated that this phosphoprotein can bind the kappa B element directly and specifically.", "output": {"entities": {"gene": [{"text": "kappa B element", "start": 78, "end": 93}]}}, "schema": []}
{"input": "The minus-end-directed microtubule motors, the dyneins, may also constitute a superfamily of force-generating proteins with distinct attachment domains.", "output": {"entities": {"gene": [{"text": "dyneins", "start": 47, "end": 54}]}}, "schema": []}
{"input": "The incompatibility group W plasmid pSa suppresses Agrobacterium tumefaciens oncogenicity (J.", "output": {"entities": {}}, "schema": []}
{"input": "Potential translational start signals are upstream of ORF1 and ORF2.", "output": {"entities": {}}, "schema": []}
{"input": "Imaging of D2 dopamine receptor", "output": {"entities": {}}, "schema": []}
{"input": "The abundance of transcripts from several unrelated genes is decreased in cdc68-1 mutant cells after transfer to the restrictive temperature, while at least one transcript, from the HSP82 gene, persists in an aberrant fashion.", "output": {"entities": {"gene": [{"text": "cdc68-1 mutant", "start": 74, "end": 88}, {"text": "HSP82 gene", "start": 182, "end": 192}]}}, "schema": []}
{"input": "The murine Mov-34 gene: full-length cDNA and genomic organization.", "output": {"entities": {"gene": [{"text": "murine Mov-34 gene", "start": 4, "end": 22}]}}, "schema": []}
{"input": "CREB was identified as one of the protein components in several of the gel shift complexes formed with the variant CRE.", "output": {"entities": {"gene": [{"text": "CREB", "start": 0, "end": 4}]}}, "schema": []}
{"input": "The spectrum of histologically diagnosed malignant neoplasms in Sabah, 1983-1988.", "output": {"entities": {}}, "schema": []}
{"input": "When transfected into Drosophila SL-2 cells, pCAT plasmid containing 2, 090 bp of 5'-flanking region shows a 3. 0-to 3. 5-fold increase in chloramphenicol acetyltransferase activity after induction with retinoic acid and/or 8-bromo-cAMP.", "output": {"entities": {"gene": [{"text": "chloramphenicol acetyltransferase", "start": 139, "end": 172}]}}, "schema": []}
{"input": "Two alternatively spliced 5' UTRs, designated type I and type II, of 222 and 115 bp, respectively, were found associated with PFP.", "output": {"entities": {"gene": [{"text": "PFP", "start": 126, "end": 129}]}}, "schema": []}
{"input": "The N-terminus of another open reading frame was found 3' from nifA and tentatively identified as nifB by amino acid sequence comparison.", "output": {"entities": {"gene": [{"text": "nifA", "start": 63, "end": 67}, {"text": "nifB", "start": 98, "end": 102}]}}, "schema": []}
{"input": "The RNA genome of rabbit hemorrhagic disease virus (RHDV) was molecularly cloned.", "output": {"entities": {}}, "schema": []}
{"input": "Therefore, we have developed a system to study nuclear targeting in plants and have established that the nuclear transport machinery is similar in monocots and dicots.", "output": {"entities": {}}, "schema": []}
{"input": "A novel cDNA clone termed R2 was isolated by subtractive hybridization of a cDNA library of phytohemagglutinin (PHA)/phorbol myristate acetate-stimulated Jurkat cells and by rescreening a cDNA library of PHA-stimulated peripheral blood lymphocytes.", "output": {"entities": {"gene": [{"text": "phytohemagglutinin", "start": 92, "end": 110}, {"text": "PHA", "start": 112, "end": 115}]}}, "schema": []}
{"input": "Chagas' disease, visceral leishmaniasis, anti-nuclear factor, schistosomiasis, rheumatoid factor and normal controls.", "output": {"entities": {"gene": [{"text": "anti-nuclear factor", "start": 41, "end": 60}, {"text": "rheumatoid factor", "start": 79, "end": 96}]}}, "schema": []}
{"input": "The second transcriptional unit, designated UL26. 5, predicted to specify a protein of 329 amino acids, encodes the family 35 proteins; it is transcribed by an mRNA which initiates at approximately nucleotide + 1000 of the UL26 transcription initiation site and is translated from the methionine initiation codon located at position + 1099 of the UL26 transcriptional unit.", "output": {"entities": {"gene": [{"text": "UL26. 5", "start": 44, "end": 51}, {"text": "family 35 proteins", "start": 116, "end": 134}, {"text": "UL26", "start": 223, "end": 227}, {"text": "UL26 transcriptional unit", "start": 347, "end": 372}]}}, "schema": []}
{"input": "The adeno-associated virus (AAV) rep gene encodes four proteins (Rep78, Rep68, Rep52, and Rep40) required for AAV DNA replication and AAV gene regulation.", "output": {"entities": {"gene": [{"text": "adeno-associated virus (AAV) rep gene", "start": 4, "end": 41}, {"text": "Rep78", "start": 65, "end": 70}, {"text": "Rep68", "start": 72, "end": 77}, {"text": "Rep52", "start": 79, "end": 84}, {"text": "Rep40", "start": 90, "end": 95}]}}, "schema": []}
{"input": "A larger region upstream of human CMV dbp also mediated replication in transient assays.", "output": {"entities": {"gene": [{"text": "human CMV dbp", "start": 28, "end": 41}]}}, "schema": []}
{"input": "It also contains a picornaviral 3C-like protease domain and two papain-like protease domains.", "output": {"entities": {"gene": [{"text": "picornaviral 3C-like protease domain", "start": 19, "end": 55}, {"text": "papain-like protease domains", "start": 64, "end": 92}]}}, "schema": []}
{"input": "However, the relative positions of the VV genes (genus Orthopoxvirus) are different than those of the corresponding ORFs in SFV (genus Leporipoxvirus), indicating complex rearrangements of DNA in the genome of one or both of these viruses subsequent to their divergence from a common ancestor.", "output": {"entities": {}}, "schema": []}
{"input": "This result suggests that phosphorylation of Thr 14 and/or Tyr 15 inhibits p34cdc2 kinase activity, in line with the location of these residues within the putative ATP binding site of the kinase.", "output": {"entities": {"gene": [{"text": "p34cdc2 kinase", "start": 75, "end": 89}]}}, "schema": []}
{"input": "In short-term cotransfections, a pFRTK-CAT target containing EBNA-1-binding sites from the EBV origin of plasmid replication, ori-P, was transactivated by a carboxy-terminal EBNA-1 construction (amino acids 450 to 641) that also carried a c-myc nuclear localization signal.", "output": {"entities": {"gene": [{"text": "pFRTK", "start": 33, "end": 38}, {"text": "CAT", "start": 39, "end": 42}, {"text": "EBNA-1-binding sites", "start": 61, "end": 81}, {"text": "ori-P", "start": 126, "end": 131}, {"text": "carboxy-terminal EBNA-1 construction", "start": 157, "end": 193}, {"text": "c-myc nuclear localization signal", "start": 239, "end": 272}]}}, "schema": []}
{"input": "The findings are compatible with the idea that the genes encoding PDGF receptors in glioma cells are regulated in concert with other genes, the expression of which may reflect the developmental program of normal glia cell lineages.", "output": {"entities": {"gene": [{"text": "PDGF receptors", "start": 66, "end": 80}]}}, "schema": []}
{"input": "Suggestive evidence was obtained that cstA is involved in peptide utilization.", "output": {"entities": {"gene": [{"text": "cstA", "start": 38, "end": 42}]}}, "schema": []}
{"input": "This study tested the hypothesis that sodium channel blocking drugs selectively prolong the late potential, or terminal low amplitude signal, portion of the signal-averaged QRS complex and that prolongation of the late potential would correlate with slowing of ventricular tachycardia.", "output": {"entities": {}}, "schema": []}
{"input": "Identification and nucleotide sequence of Rhizobium meliloti insertion sequence ISRm3: similarity between the putative transposase encoded by ISRm3 and those encoded by Staphylococcus aureus IS256 and Thiobacillus ferrooxidans IST2.", "output": {"entities": {"gene": [{"text": "Rhizobium meliloti insertion sequence ISRm3", "start": 42, "end": 85}, {"text": "transposase", "start": 119, "end": 130}, {"text": "ISRm3", "start": 142, "end": 147}, {"text": "Staphylococcus aureus IS256", "start": 169, "end": 196}, {"text": "Thiobacillus ferrooxidans IST2", "start": 201, "end": 231}]}}, "schema": []}
{"input": "To determine the relationship of these viruses, the complete DNA sequence of KV consisting of 4754 bp was determined.", "output": {"entities": {}}, "schema": []}
{"input": "Whereas a PR55 beta transcript of about 2. 3 kb was detected at high levels in the neuroblastoma derived cell line LA-N-1, the level of the mRNA was very low in the other human cell lines analyzed.", "output": {"entities": {"gene": [{"text": "PR55 beta transcript", "start": 10, "end": 30}]}}, "schema": []}
{"input": "Heterodimers of myogenin and E12 (or MyoD and E12) specifically bound a restriction fragment extending from-200 to-103 relative to the start of cardiac alpha-actin transcription.", "output": {"entities": {"gene": [{"text": "myogenin", "start": 16, "end": 24}, {"text": "E12", "start": 29, "end": 32}, {"text": "MyoD", "start": 37, "end": 41}, {"text": "E12", "start": 46, "end": 49}, {"text": "cardiac alpha-actin", "start": 144, "end": 163}]}}, "schema": []}
{"input": "The effects of c-myc were further dissected by showing that c-myc can inhibit differentiation independently of Id, a negative regulator of muscle differentiation.", "output": {"entities": {"gene": [{"text": "c-myc", "start": 15, "end": 20}, {"text": "c-myc", "start": 60, "end": 65}, {"text": "Id", "start": 111, "end": 113}]}}, "schema": []}
{"input": "Stable association of U2 snRNP with the branchpoint sequence of mammalian pre-mRNAs requires binding of a non-snRNP protein to the polypyrimidine tract.", "output": {"entities": {"gene": [{"text": "U2 snRNP", "start": 22, "end": 30}]}}, "schema": []}
{"input": "The Italian Lung Cancer Task Force (FONICAP).", "output": {"entities": {}}, "schema": []}
{"input": "The promoter activity of the gene encoding Alzheimer beta-amyloid precursor protein (APP) is regulated by two blocks of upstream sequences.", "output": {"entities": {"gene": [{"text": "gene encoding Alzheimer beta-amyloid precursor protein", "start": 29, "end": 83}, {"text": "APP", "start": 85, "end": 88}]}}, "schema": []}
{"input": "This element was used to screen an EMBL3 mouse genomic library.", "output": {"entities": {}}, "schema": []}
{"input": "The MVV-value is under the predicted level in the case of 67-76 percent.", "output": {"entities": {}}, "schema": []}
{"input": "The rad9. 192 DNA repair mutant from the fission yeast, Schizosaccharomyces pombe, is sensitive to both UV and ionising radiation.", "output": {"entities": {"gene": [{"text": "rad9. 192 DNA repair mutant from the fission yeast, Schizosaccharomyces pombe", "start": 4, "end": 81}]}}, "schema": []}
{"input": "Review: deterioration of glucose tolerance with age: the role of insulin resistance.", "output": {"entities": {"gene": [{"text": "insulin", "start": 65, "end": 72}]}}, "schema": []}
{"input": "The 5' region shows strong sequence similarity to Escherichia coli consensus promoters and ribosome-binding sequences and allows high levels of expression in E. coli.", "output": {"entities": {}}, "schema": []}
{"input": "Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase.", "output": {"entities": {"gene": [{"text": "RCC1", "start": 49, "end": 53}, {"text": "GTPase", "start": 72, "end": 78}]}}, "schema": []}
{"input": "The method has been routinely used in our laboratory for 1 year and has proven to be a reliable procedure for the biological control of occupational exposure to toluene and/or xylene.", "output": {"entities": {}}, "schema": []}
{"input": "The patient was a 78-year-old male in whom skin lesions preceded the diagnosis of myelofibrosis.", "output": {"entities": {}}, "schema": []}
{"input": "Oculus-500 is a group of high resolution imaging boards for use with IBM-AT and compatible computers.", "output": {"entities": {}}, "schema": []}
{"input": "After resection of the proximal fragment, all scaphoid contact area and pressure was born by the distal scaphoid fragment.", "output": {"entities": {}}, "schema": []}
{"input": "Plate luting, a technique that uses polymethylmethacrylate (PMMA) interposed between the plate and the bone, as well as between the screw heads and the plate, to improve the stability of internal fixation was tested in vitro using 20 paired equine third metacarpal bones with mid-diaphyseal osteotomies plated with six-hole broad ASIF compression plates.", "output": {"entities": {}}, "schema": []}
{"input": "These features were considered consistent with a diagnosis of Rothmund-Thomson syndrome.", "output": {"entities": {}}, "schema": []}
{"input": "Thyroid lymphoma and its management.", "output": {"entities": {}}, "schema": []}
{"input": "The protein encoded by ORF113 contains a transmembrane domain.", "output": {"entities": {"gene": [{"text": "ORF113", "start": 23, "end": 29}]}}, "schema": []}
{"input": "Space limitations prevent an exhaustive review of all biologic pharmaceuticals, such as tissue plasminogen activating substance, hormones (e. g., thyroid, insulin, growth hormone, erythropoietin), clotting factors, and blood products.", "output": {"entities": {"gene": [{"text": "tissue plasminogen activating substance", "start": 88, "end": 127}, {"text": "insulin", "start": 155, "end": 162}, {"text": "growth hormone", "start": 164, "end": 178}, {"text": "erythropoietin", "start": 180, "end": 194}]}}, "schema": []}
{"input": "The various forms of sickle cell disease share the common feature of an abnormal globin chain that, under certain conditions such as hypoxia, results in the sickling of red blood cells and obstruction of blood vessels.", "output": {"entities": {"gene": [{"text": "globin chain", "start": 81, "end": 93}]}}, "schema": []}
{"input": "The primary structure of each of the three proteins has about 70% homology with that of mouse contrapsin, in contrast to 43-46% homology with that of rat alpha 1-protease inhibitor.", "output": {"entities": {"gene": [{"text": "mouse contrapsin", "start": 88, "end": 104}, {"text": "rat alpha 1-protease", "start": 150, "end": 170}]}}, "schema": []}
{"input": "Patterns of connections underlying cross-modality integration were studied by injecting distinguishable, retrograde tracers (Fluoro-Gold and diamidino yellow) in pairwise manner into different sensory representations (visual, somatosensory, and auditory) in the cerebral cortex of the rat.", "output": {"entities": {}}, "schema": []}
{"input": "The across-fiber pattern of the responses to hypotonic NaCl solutions correlated strongly to that elicited by distilled H2O. (ABSTRACT TRUNCATED AT 400 WORDS)", "output": {"entities": {}}, "schema": []}
{"input": "Human immunodeficiency virus type 1 (HIV-1) IN, expressed in Escherichia coli, was purified to near homogeneity.", "output": {"entities": {"gene": [{"text": "Human immunodeficiency virus type 1 (HIV-1) IN", "start": 0, "end": 46}]}}, "schema": []}
{"input": "Thigh girth correlated positively with HDL and HDL2-C and mass, and with LDL particle size among women.", "output": {"entities": {"gene": [{"text": "HDL", "start": 39, "end": 42}, {"text": "HDL2-C", "start": 47, "end": 53}, {"text": "LDL", "start": 73, "end": 76}]}}, "schema": []}
{"input": "Contributions from pairs of source and target volume elements are summed for the S values between the tumor and itself, between the remaining healthy host organ and itself, and between the tumor and the remaining healthy host organ, with the reciprocity theorem assumed for the last.", "output": {"entities": {}}, "schema": []}
{"input": "Tests showed that an overall impression of the force applied could be obtained from a laboratory simulation, but that clearing cement and testing cement were not modelled by this method.", "output": {"entities": {}}, "schema": []}
{"input": "The cDNA contained an open reading frame of 1392 bp that predicted a protein of 464 amino acids and a molecular mass of 52 kDa; this protein has 97% identity to rat liver glucokinase.", "output": {"entities": {"gene": [{"text": "rat liver glucokinase", "start": 161, "end": 182}]}}, "schema": []}
{"input": "Analysis of viral mutants in vivo demonstrated that the NFIII/OCT-1 binding site and a conserved ATF motif were important for efficient viral growth.", "output": {"entities": {"gene": [{"text": "NFIII", "start": 56, "end": 61}, {"text": "OCT-1", "start": 62, "end": 67}, {"text": "ATF motif", "start": 97, "end": 106}]}}, "schema": []}
{"input": "Recovery of radiolabelled BA through urine (28%) and faeces (22%) up to 96 hrs averaged 50%, whereas residual radioactivity in liver and testis experienced a recovery of 29% in scorbutic animals.", "output": {"entities": {}}, "schema": []}
{"input": "Paradoxically, however, the GH receptor cloned from liver exhibits no sequence similarity to receptors with known signal transduction mechanisms, including those exhibiting ligand-activated tyrosine kinase activity.", "output": {"entities": {"gene": [{"text": "GH receptor", "start": 28, "end": 39}, {"text": "tyrosine kinase", "start": 190, "end": 205}]}}, "schema": []}
{"input": "This indicates that under certain experimental conditions cdc2/p58 and cdc2/p62 may express some differences in their catalytic activity.", "output": {"entities": {"gene": [{"text": "cdc2", "start": 58, "end": 62}, {"text": "p58", "start": 63, "end": 66}, {"text": "cdc2", "start": 71, "end": 75}, {"text": "p62", "start": 76, "end": 79}]}}, "schema": []}
{"input": "Mutation analysis implicated multiple segments of the 5' untranslated region as contributing to the inhibitory effect.", "output": {"entities": {}}, "schema": []}
{"input": "Identification of Ets-and notch-related subunits in GA binding protein.", "output": {"entities": {"gene": [{"text": "Ets", "start": 18, "end": 21}, {"text": "notch", "start": 26, "end": 31}, {"text": "GA binding protein", "start": 52, "end": 70}]}}, "schema": []}
{"input": "The enzymatic response of neutrophils and monocytes was similar although the magnitude of the NADPH oxidase activity was significantly higher in neutrophils than in monocytes.", "output": {"entities": {"gene": [{"text": "NADPH oxidase", "start": 94, "end": 107}]}}, "schema": []}
{"input": "In the ileum, enterotoxin increased the luminal disappearance (P less than 0. 05) and peripheral blood appearance (P less than 0. 001) of chloroquine.", "output": {"entities": {}}, "schema": []}
{"input": "It is concluded that attention to these issues can substantially improve the quality of research on AIDS related behaviors on Black communities.", "output": {"entities": {}}, "schema": []}
{"input": "The effectiveness of alpha-mercapto-beta-(2-furyl) acrylic acid (MFA) and N-benzyl-N-dithiocarboxy-D-glucamine (NaB), used in combination, in the mobilization and excretion of lead was investigated in rats.", "output": {"entities": {}}, "schema": []}
{"input": "These results suggest that beta-1 may act as a tissue-specific, trans-acting regulator of the expression of the beta-zein gene in developing maize endosperm.", "output": {"entities": {"gene": [{"text": "beta-1", "start": 27, "end": 33}, {"text": "beta-zein gene", "start": 112, "end": 126}]}}, "schema": []}
{"input": "This study examines the effects of hypovolemia on the extracellular ptO2 and ptH distributions at multiple tissue sites using a recently developed multipoint microelectrode, that provides simultaneous measurements of ptO2 and ptH.", "output": {"entities": {}}, "schema": []}
{"input": "All members are also capable of activating in vivo transcription from promoters that contain a C/EBP-binding site.", "output": {"entities": {"gene": [{"text": "C/EBP-binding site", "start": 95, "end": 113}]}}, "schema": []}
{"input": "The domains involved in superactivation appear to be a subset of those necessary to achieve synergistic activation.", "output": {"entities": {}}, "schema": []}
{"input": "Information on conserved noncoding sequences will help in studies on the regulation of the pro alpha 1 (II) collagen gene.", "output": {"entities": {"gene": [{"text": "pro alpha 1 (II) collagen gene", "start": 91, "end": 121}]}}, "schema": []}
{"input": "Chlamydia trachomatis and Chlamydia psittaci were not affected by methanol fixation.", "output": {"entities": {}}, "schema": []}
{"input": "Although human infections with bacteraemia due to Pasteurella multocida are not uncommon, endocarditis associated with P. haemolytica is rare.", "output": {"entities": {}}, "schema": []}
{"input": "For SMX at pH 7. 0, a 1: 1 complex is formed, but at pH 7. 5 HPCD has little effect on the solubility of the highly ionized SMX, presumably since only un-ionized molecules can form inclusion complexes with the HPCD.", "output": {"entities": {}}, "schema": []}
{"input": "PO2 measurements using a double barrelled recess type microelectrodes were measured in the optic nerve head of miniature pigs in normoxia and hyperoxia.", "output": {"entities": {}}, "schema": []}
{"input": "POU-specific and POU-homeo domains of Oct3 were produced in Echerichia coli for characterization of DNA binding to the octamer sequence.", "output": {"entities": {"gene": [{"text": "POU", "start": 0, "end": 3}, {"text": "POU", "start": 17, "end": 20}, {"text": "Oct3", "start": 38, "end": 42}]}}, "schema": []}
{"input": "The nucleotide (nt) sequences of the exons, exon/intron boundaries and 5'-and 3'-untranslated regions were determined.", "output": {"entities": {}}, "schema": []}
{"input": "Out of 40 patients, who initially did not show eye complications due to leprosy, 37 patients were essentially the same 10 years later.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, two very different regulatory elements are used to mediate estrogen induction of related genes in chickens and amphibians.", "output": {"entities": {}}, "schema": []}
{"input": "Experimentally in green monkeys, Syrian hamsters and white mice the authors studied the pathogenic properties of a new virus Issyk-Kul.", "output": {"entities": {}}, "schema": []}
{"input": "Increasing mean arterial pressure by phenylephrine infusion to levels much greater than produced by NMA and NNA caused only small reductions in cardiac output.", "output": {"entities": {}}, "schema": []}
{"input": "J.", "output": {"entities": {}}, "schema": []}
{"input": "With stepwise reductions in flow, the peak (S) and trough (D) points of the maximum shifted-frequency envelope fell in parallel in a linear fashion until D reached zero.", "output": {"entities": {}}, "schema": []}
{"input": "The IE0 gene product also transactivated the IE1 promoter but did not affect expression from its own promoter.", "output": {"entities": {"gene": [{"text": "IE0 gene", "start": 4, "end": 12}, {"text": "IE1 promoter", "start": 45, "end": 57}]}}, "schema": []}
{"input": "Evaluation of left ventricular function using gated planar myocardial imaging with Tc-99m-MIBI", "output": {"entities": {}}, "schema": []}
{"input": "Bone marrow abnormalities in Hodgkin' s disease are reviewed and the current understanding of the pathological mechanisms leading to aplastic anemia is discussed.", "output": {"entities": {}}, "schema": []}
{"input": "The smaller uptake rate and faster clearance rate resulted in the lower BCF for SWA killifish.", "output": {"entities": {}}, "schema": []}
{"input": "Increases in the perfusate PCO2 but not in the perfusate H + were highly correlated with decreases in both myocardial contractility and oxygen consumption (r2 =. 88).", "output": {"entities": {}}, "schema": []}
{"input": "Expression was cell cycle controlled, with steady-state RNA levels significantly higher in growth-arrested than in growth-stimulated cells.", "output": {"entities": {}}, "schema": []}
{"input": "Determinants of recurrent ischaemia and revascularisation procedures after thrombolysis with recombinant tissue plasminogen activator in primary coronary occlusion.", "output": {"entities": {"gene": [{"text": "tissue plasminogen activator", "start": 105, "end": 133}]}}, "schema": []}
{"input": "Therefore, the rbcL-rbcS locus seems to be barely expressed under a standard condition for photoautotrophic growth.", "output": {"entities": {"gene": [{"text": "rbcL", "start": 15, "end": 19}, {"text": "rbcS", "start": 20, "end": 24}]}}, "schema": []}
{"input": "Relationship between mitochondrial NADH-ubiquinone reductase and a bacterial NAD-reducing hydrogenase.", "output": {"entities": {"gene": [{"text": "mitochondrial NADH-ubiquinone reductase", "start": 21, "end": 60}, {"text": "bacterial NAD-reducing hydrogenase", "start": 67, "end": 101}]}}, "schema": []}
{"input": "Analysis of mRNA expression shows that AT-BP1 and AT-BP2 are expressed in all the tissues examined.", "output": {"entities": {"gene": [{"text": "AT-BP1", "start": 39, "end": 45}, {"text": "AT-BP2", "start": 50, "end": 56}]}}, "schema": []}
{"input": "3 cases", "output": {"entities": {}}, "schema": []}
{"input": "Sequence requirements for premature transcription arrest within the first intron of the mouse c-fos gene.", "output": {"entities": {"gene": [{"text": "mouse c-fos gene", "start": 88, "end": 104}]}}, "schema": []}
{"input": "Infarct regional ejection fraction improved by 10. 1 +/-2. 1% between early and late studies when the infarct-related artery was patent and by 4. 8 +/-1. 4% if it was occluded (p = 0. 048); changes in global and noninfarct regional ejection fraction were similar irrespective of perfusion status.", "output": {"entities": {}}, "schema": []}
{"input": "One of its lysine residues is modified by spermidine to form hypusine, a posttranslational modification unique to eIF-5A.", "output": {"entities": {"gene": [{"text": "eIF-5A", "start": 114, "end": 120}]}}, "schema": []}
{"input": "The plasmid shuffle technique was used to replace the wild-type gene with the mutant form, resulting in failure of the yeast cells to grow.", "output": {"entities": {}}, "schema": []}
{"input": "If this is the case, identification and characterization of transcripts from the Ig loci should permit a better understanding of the gene rearrangement process.", "output": {"entities": {"gene": [{"text": "Ig loci", "start": 81, "end": 88}]}}, "schema": []}
{"input": "Transcription of the metH gene in Salmonella typhimurium and Escherichia coli is positively regulated by the metR gene product, a DNA binding protein.", "output": {"entities": {"gene": [{"text": "metH gene in Salmonella typhimurium and Escherichia coli", "start": 21, "end": 77}, {"text": "metR gene product", "start": 109, "end": 126}]}}, "schema": []}
{"input": "Disruption of the chromosomal AAR1 gene in alpha and a/alpha cells conferred the nonmating phenotype, and the a/alpha diploids could not sporulate.", "output": {"entities": {"gene": [{"text": "chromosomal AAR1 gene", "start": 18, "end": 39}]}}, "schema": []}
{"input": "The effect of ICRF-187 on the antitumor response induced by the combination of ADR and WBH was also investigated in order to assess alterations in the therapeutic index of this combined therapeutic modality treatment.", "output": {"entities": {}}, "schema": []}
{"input": "The ORF was analyzed for secondary structural features, and the sequence data bases were searched for homologies.", "output": {"entities": {}}, "schema": []}
{"input": "Mitomycin-C can cause severe necrosis and ulceration when extravasated inadvertently into skin and soft tissues following IV drug administration.", "output": {"entities": {}}, "schema": []}
{"input": "In this study, we have cloned the 5'-flanking region of the human nidogen gene.", "output": {"entities": {"gene": [{"text": "human nidogen gene", "start": 60, "end": 78}]}}, "schema": []}
{"input": "Consistent with the in vivo result, the pseudorevertant endonucleases in the crude cell extract display site-specific partial DNA cleavage activity.", "output": {"entities": {}}, "schema": []}
{"input": "Additionally, I kappa B beta, but not I kappa B alpha, also prevented the binding of Rel to the kappa B site.", "output": {"entities": {"gene": [{"text": "I kappa B beta", "start": 14, "end": 28}, {"text": "I kappa B alpha", "start": 38, "end": 53}, {"text": "Rel", "start": 85, "end": 88}, {"text": "kappa B site", "start": 96, "end": 108}]}}, "schema": []}
{"input": "Sequence analysis reveals that the DNA binding domain of ILF has strong homology to the recently described fork head DNA binding domain found in the Drosophila homeotic protein fork head and a family of hepatocyte nuclear factors, HNF-3.", "output": {"entities": {"gene": [{"text": "ILF", "start": 57, "end": 60}, {"text": "fork head DNA binding domain", "start": 107, "end": 135}, {"text": "Drosophila homeotic protein fork head", "start": 149, "end": 186}, {"text": "hepatocyte nuclear factors", "start": 203, "end": 229}, {"text": "HNF-3", "start": 231, "end": 236}]}}, "schema": []}
{"input": "Lengthy and repeated hemodialyses were required to lower lithemia to nontoxic ranges.", "output": {"entities": {}}, "schema": []}
{"input": "A single i. p. injection of d, l-baclofen 10 mg/kg both reduced noradrenaline (NA) biosynthesis in vivo (31%) and the endogenous concentration of normetanephrine (NMN) (32%) and increased NA levels (28%).", "output": {"entities": {}}, "schema": []}
{"input": "Fufang wuzi yanzong pills have strong leukogenic effect on cyclophosphamide induced leukopenia in mice.", "output": {"entities": {}}, "schema": []}
{"input": "Mutations in the small subunit of ribulosebisphosphate carboxylase affect subunit binding and catalysis.", "output": {"entities": {"gene": [{"text": "ribulosebisphosphate carboxylase", "start": 34, "end": 66}]}}, "schema": []}
{"input": "The structural changes in intra-acinar artery manifested mainly by an increase in number of muscular artery resulting from muscularization of precursor cells (pericytes and intermediate cells) located within partially muscular and nonmuscular arterial wall to smooth muscle cell, and by the medial wall thickened due to hypertrophy and hyperplasia of smooth muscle cells as well as accumulation of a large amount of collagen, especially the type 1 collagen.", "output": {"entities": {"gene": [{"text": "collagen", "start": 416, "end": 424}, {"text": "type 1 collagen", "start": 441, "end": 456}]}}, "schema": []}
{"input": "These results suggest that NZ-107 may be a useful drug for the treatment of bronchial asthma by reducing late-phase airway responses and airway hyperreactivity.", "output": {"entities": {}}, "schema": []}
{"input": "In study 2, the correlation coefficients between the ISO2 measurements obtained at the ulcer margin and at the adjacent normal mucosa, and delta ISO2 obtained by the experienced observer and one of the three learners were 0. 94, 0. 97, and 0. 94, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Bronchial mucosa tattooing in persons exposed to different industrial aerosols did not depend on the forms of PC, DB and the diseases' stages.", "output": {"entities": {}}, "schema": []}
{"input": "Anti-HBc production of PBMC was enhanced remarkably in this case.", "output": {"entities": {"gene": [{"text": "Anti-HBc", "start": 0, "end": 8}]}}, "schema": []}
{"input": "Lipoprotein lipase (LPL), a key enzyme in normal lipoprotein metabolism, has a complex pattern of regulation and tissue-specific expression.", "output": {"entities": {"gene": [{"text": "Lipoprotein lipase", "start": 0, "end": 18}, {"text": "LPL", "start": 20, "end": 23}]}}, "schema": []}
{"input": "Deletion of the proximal octanucleotide motif from the plasmid containing the-461 fragment of the LPL promoter, resulted in a 79 and 76% decrease in the level of expression in transfected 3T3-L1 adipocytes and HepG2 hepatocytes, respectively.", "output": {"entities": {"gene": [{"text": "LPL promoter", "start": 98, "end": 110}]}}, "schema": []}
{"input": "We examined the binding of purified T3 receptor alpha (T3R alpha), overexpressed in Escherichia coli, to wild-type and up and down mutations of the rGH T3RE to evaluate whether transcriptional potency correlates with changes in T3R binding.", "output": {"entities": {"gene": [{"text": "T3 receptor alpha", "start": 36, "end": 53}, {"text": "T3R alpha", "start": 55, "end": 64}, {"text": "rGH T3RE", "start": 148, "end": 156}, {"text": "T3R", "start": 228, "end": 231}]}}, "schema": []}
{"input": "Comparison of the cDNA-predicted avian TnIcardiac amino acid sequences with known TnI sequences indicated 1) that the presence of an N-terminal extension sequence carrying a dual protein kinase A phosphorylation target site and an adjacent proline-rich segment is an ancient cardiac-specific feature of TnI which has been conserved since the bird/mammal divergence, 2) that features of the near-N-terminal troponin C (TnC)-binding site sequence suggest isoform-specific adaptation of TnI and TnC, and 3) that the avian TnIcardiac internal actin/TnC-binding, actomyosin-inhibitory, domain shows significant sequence divergence from mammalian TnIcardiac sequences, including the absence of a protein kinase C target site which is a cardiac-specific feature of TnI in mammals.", "output": {"entities": {"gene": [{"text": "avian TnIcardiac amino acid sequences", "start": 33, "end": 70}, {"text": "TnI sequences", "start": 82, "end": 95}, {"text": "protein kinase A", "start": 179, "end": 195}, {"text": "TnI", "start": 303, "end": 306}, {"text": "troponin C", "start": 406, "end": 416}, {"text": "TnC", "start": 418, "end": 421}, {"text": "TnI", "start": 484, "end": 487}, {"text": "TnC", "start": 492, "end": 495}, {"text": "TnIcardiac", "start": 519, "end": 529}, {"text": "actin/TnC-binding, actomyosin-inhibitory, domain", "start": 539, "end": 587}, {"text": "mammalian TnIcardiac sequences", "start": 631, "end": 661}, {"text": "protein kinase C", "start": 690, "end": 706}, {"text": "TnI", "start": 758, "end": 761}]}}, "schema": []}
{"input": "Ventilatory management casebook.", "output": {"entities": {}}, "schema": []}
{"input": "An ASSEMBLER routine for on-line graphic display and averaging of data acquired on a personal microcomputer.", "output": {"entities": {}}, "schema": []}
{"input": "Expression of the mouse TSH beta gene, therefore, gives rise to multiple mRNAs, each with a unique 5'-untranslated region.", "output": {"entities": {"gene": [{"text": "mouse TSH beta gene", "start": 18, "end": 37}]}}, "schema": []}
{"input": "It was found that the ROSP undergoes a number of fluctuations in the negative and positive directions with a gradually decreasing amplitude in the course of 5-25 days following the operation, after which relatively stable negative values of the ROSP are established on the average in electrodes implanted to the level of the dura mater, and positive values in electrodes implanted to the level of the pia mater.", "output": {"entities": {}}, "schema": []}
{"input": "Blood flow velocity waveforms were recorded by pulsed Doppler examination of the fetal internal carotid and middle cerebral arteries using the established transabdominal route as well as a new transvaginal approach.", "output": {"entities": {}}, "schema": []}
{"input": "Quantitative analysis of DNA using flow cytometry and immunocytochemical findings in 16 cases of cardiac myxomas", "output": {"entities": {}}, "schema": []}
{"input": "Sequence analysis revealed that in addition to the non-spliced variant, multiple mRNA species were generated by alternative splicing resulting in the exclusion of 92, 166, 170, 174 and 263 nucleotides (nt), respectively, from exon 1.", "output": {"entities": {}}, "schema": []}
{"input": "Position 22 is an isoleucine in the complete SsoL12 protein sequence, coded by an AUA codon.", "output": {"entities": {"gene": [{"text": "complete SsoL12 protein sequence", "start": 36, "end": 68}]}}, "schema": []}
{"input": "Symptoms due to the action of mastocyte mediators were observed.", "output": {"entities": {}}, "schema": []}
{"input": "In the yeast Saccharomyces cerevisiae, copper levels exert some control over the level of SOD1 expression.", "output": {"entities": {"gene": [{"text": "SOD1", "start": 90, "end": 94}]}}, "schema": []}
{"input": "Of these 179 samples, Mobiluncus SP was observed in 35 (19. 6%) using Gram staining and in 18 (10. 1%) this microorganism was isolated in agar RLK and anaerobic atmosphere.", "output": {"entities": {}}, "schema": []}
{"input": "Previous investigators have suggested that subretinal blood damages the retina in part because of its solid fibrin meshwork.", "output": {"entities": {"gene": [{"text": "fibrin", "start": 108, "end": 114}]}}, "schema": []}
{"input": "Twenty-four hours later, the animals were randomized to subretinal treatment with 2. 5 micrograms of tissue plasminogen activator or a similar volume of physiologic saline.", "output": {"entities": {"gene": [{"text": "tissue plasminogen activator", "start": 101, "end": 129}]}}, "schema": []}
{"input": "Neuro-otological examinations revealed spontaneous downbeat nystagmus, bilateral gaze nystagmus and rebound nystagmus.", "output": {"entities": {}}, "schema": []}
{"input": "Since the morphology of the lesions can mimic that of other cutaneous disorders, Bowen' s disease is often not recognized initially.", "output": {"entities": {}}, "schema": []}
{"input": "Equine amnion and live yeast cell derivative were evaluated as a biological dressing and as a topical wound medicament respectively, in the treatment of granulating wounds of the distal portion of the limbs of horses.", "output": {"entities": {}}, "schema": []}
{"input": "To lower the current high incidence of NANB-induced PTH, in 1986, the American Association of Blood Banks (AABB) recommended testing for these PTH-associated \" surrogate \" markers on all donated units of blood.", "output": {"entities": {}}, "schema": []}
{"input": "Fusion of ubiquitin to pADPRP increased the yield of pADPRP approximately 10-fold compared to that of the unfused enzyme.", "output": {"entities": {"gene": [{"text": "ubiquitin", "start": 10, "end": 19}, {"text": "pADPRP", "start": 23, "end": 29}, {"text": "pADPRP", "start": 53, "end": 59}]}}, "schema": []}
{"input": "In group III, patients also received their own mediastinal drainage blood, shed for 6 hours after operation, after concentration and washing in a MBRS.", "output": {"entities": {}}, "schema": []}
{"input": "The effect of salmon calcitonin nasal spray in women with established osteoporosis has also been studied.", "output": {"entities": {"gene": [{"text": "salmon calcitonin", "start": 14, "end": 31}]}}, "schema": []}
{"input": "Skeletal muscle metaboreceptor responses are impaired in heart failure.", "output": {"entities": {}}, "schema": []}
{"input": "Skeletal muscle metaboreceptor exercise responses are attenuated in heart failure.", "output": {"entities": {}}, "schema": []}
{"input": "Evaluation of antiepileptic drug effect on membrane fluidity.", "output": {"entities": {}}, "schema": []}
{"input": "The examinations were performed on two groups of 20 (using AmF/SnF2)-, resp.", "output": {"entities": {}}, "schema": []}
{"input": "The vaccine used was known to be immunogenic for older children and adults.", "output": {"entities": {}}, "schema": []}
{"input": "Both groups then underwent hypnotic induction, and completed the test again (R2).", "output": {"entities": {}}, "schema": []}
{"input": "Applications of three-dimensional analysis to the auditory P300.", "output": {"entities": {}}, "schema": []}
{"input": "The construct was introduced into BW2001 (xth-11, nfo-2) strain cells of Escherichia coli.", "output": {"entities": {}}, "schema": []}
{"input": "Recombinant human TFIID supported weak basal transcription in heat-treated nuclear extracts whereas a partially purified TFIID fraction from HeLa cells reconstituted a maximal level of transcription.", "output": {"entities": {"gene": [{"text": "Recombinant human TFIID", "start": 0, "end": 23}, {"text": "TFIID", "start": 121, "end": 126}]}}, "schema": []}
{"input": "Only after a pretreatment aimed at increasing its oxide surface layer was titanium powder found to accelerate the precipitation from solutions containing 2 mmol/L CaCl2, 2 mmol/L KH2PO4, 50 mmol/L Hepes, pH 7. 2, and to induce precipitation from metastable solutions containing 1. 2 mmol/L CaCl2, 1. 2 mmol/L KH2PO4, 50 mmol/L Hepes, pH 7. 2, at 37 degrees C.", "output": {"entities": {}}, "schema": []}
{"input": "We conclude that solidification could occur in all feeds containing casein and that alternative feeds should be considered in patients with increased gastric acidity.", "output": {"entities": {"gene": [{"text": "casein", "start": 68, "end": 74}]}}, "schema": []}
{"input": "Neither model, as applied, provided a satisfactory account of the effects of the main variables of number of tones and amount of perturbation. (ABSTRACT TRUNCATED AT 400 WORDS)", "output": {"entities": {}}, "schema": []}
{"input": "Determination of an RNA structure involved in splicing inhibition of a muscle-specific exon.", "output": {"entities": {}}, "schema": []}
{"input": "Endothelial cells stored with University of Wisconsin solution excluded trypan blue better (1. 0% +/-0. 5% cells stained, p less than 0. 001.", "output": {"entities": {}}, "schema": []}
{"input": "The effect of diffusion limitation was quantified in terms of the ratio O2 uptake/O2 requirement (= fraction of cross-sectional area supplied with O2), assuming local O2 requirement per unit volume to be constant and independent of PO2 at PO2 greater than 0.", "output": {"entities": {}}, "schema": []}
{"input": "(2) Diffusion limitation in the heterogeneous model sets in at a lower O2 requirement value, and increases more gradually with increasing O2 requirement, than in the corresponding homogeneous models with the same average cylinder diameter.", "output": {"entities": {}}, "schema": []}
{"input": "The antihypertensive effect of Estulic has been examined over a 12-month period in 101 hypertensive patients.", "output": {"entities": {}}, "schema": []}
{"input": "At the time of the seizure, the patient was asked to read a test phrase aloud until it was read correctly and clearly.", "output": {"entities": {}}, "schema": []}
{"input": "Monitoring patients with acute leukemia for IL-1 and TNF levels throughout the clinical course of disease may help clarify the causes of febrile episodes.", "output": {"entities": {"gene": [{"text": "IL-1", "start": 44, "end": 48}, {"text": "TNF", "start": 53, "end": 56}]}}, "schema": []}
{"input": "Echinococcus granulosus was diagnosed by fine-needle aspiration cytology of a lung cyst in a 6-yr-old white female in central Missouri.", "output": {"entities": {}}, "schema": []}
{"input": "The sequence was determined of 6493 nucleotides encompassing the bet genes of Escherichia coli which encode the osmoregulatory choline-glycine betaine pathway.", "output": {"entities": {"gene": [{"text": "bet genes of Escherichia coli", "start": 65, "end": 94}]}}, "schema": []}
{"input": "A 7-day treatment of amphotericin B (5 mg/kg/day i. p.) significantly reduced the glomerular filtration rate (GFR) measured as inuline clearance and creatinine clearance (0. 74 +/-0. 29 and 0. 16 +/-0. 04 ml/min, respectively) in comparison to vehicle-treated rats (2. 04 +/-0. 23 and 1. 29 +/-0. 19 ml/min, respectively).", "output": {"entities": {}}, "schema": []}
{"input": "Confocal fluorescence microscopy in modern cell biology.", "output": {"entities": {}}, "schema": []}
{"input": "Toluene is the chemical most frequently present in cases involving volatile solvents.", "output": {"entities": {}}, "schema": []}
{"input": "Fortunately DDT-, HCH-and HCB-levels decreased in breast milk during the last years.", "output": {"entities": {}}, "schema": []}
{"input": "A herpesvirus proteinase activity has been identified and partially characterized by using the cloned enzyme and substrate genes in transient transfection assays.", "output": {"entities": {}}, "schema": []}
{"input": "Adult H, but not R, manifested the burrowing preference whenever offered the opportunity.", "output": {"entities": {}}, "schema": []}
{"input": "The rear silver liquid chamber was threefold thick to 17 MeV protons in water and it efficiently produced either 13N by the 16O (p, alpha) 13N reaction or [18F] fluoride ion by the 18O (p, n) 18F reaction.", "output": {"entities": {}}, "schema": []}
{"input": "Heterogeneous electron transfer of cytochrome c facilitated by polypyrrole and methylene blue polypyrrole film modified electrodes.", "output": {"entities": {"gene": [{"text": "cytochrome c", "start": 35, "end": 47}]}}, "schema": []}
{"input": "Selective activation of adrenaline secretion by the rat adrenal in neuroglycopenia detected via microdialysis", "output": {"entities": {}}, "schema": []}
{"input": "The 1489-base pair EFIA cDNA encodes a 322-amino acid protein which is nearly identical to two previously described human DNA binding proteins.", "output": {"entities": {"gene": [{"text": "EFIA", "start": 19, "end": 23}]}}, "schema": []}
{"input": "Four putative positive cDNA clones were isolated, and the largest insert (pASB-1) was sequenced in both orientations.", "output": {"entities": {"gene": [{"text": "pASB-1", "start": 74, "end": 80}]}}, "schema": []}
{"input": "Sci.", "output": {"entities": {}}, "schema": []}
{"input": "Dose standardisation of botulinum toxin.", "output": {"entities": {"gene": [{"text": "botulinum toxin", "start": 24, "end": 39}]}}, "schema": []}
{"input": "The coding sequence for a 260-amino-acid residue polypeptide was interrupted by a single short intron of 60 base pairs (bp), and about 70% of the deduced amino acid sequence of the Drosophila PCNA was identical to the rat and human PCNA polypeptides, with conserved unique repeats of leucine in the C-terminal region.", "output": {"entities": {"gene": [{"text": "Drosophila PCNA", "start": 181, "end": 196}, {"text": "human PCNA polypeptides", "start": 226, "end": 249}]}}, "schema": []}
{"input": "Translational fusions of the aroF regulatory regions to lacZ were constructed and then introduced in single copy into the E. coli chromosome. beta-Galactosidase assays for tyrR-mediated regulation of aroF-lacZ expression revealed that the E. coli TyrR repressor apparently recognizes the operators of both organisms with about equal efficiency.", "output": {"entities": {"gene": [{"text": "aroF regulatory regions", "start": 29, "end": 52}, {"text": "lacZ", "start": 56, "end": 60}, {"text": "beta-Galactosidase", "start": 142, "end": 160}, {"text": "aroF", "start": 200, "end": 204}, {"text": "lacZ", "start": 205, "end": 209}, {"text": "E. coli TyrR repressor", "start": 239, "end": 261}]}}, "schema": []}
{"input": "During exercise K + is released from contracting muscle and plasma K + concentration rises.", "output": {"entities": {}}, "schema": []}
{"input": "Following treatment, serum estradiol levels were higher in groups E + T and E than in group C.", "output": {"entities": {}}, "schema": []}
{"input": "We conclude that the beta-adrenergic agonist, isoproterenol, has little influence on vascular capacitance or liver volume of dogs, unless the hepatic outflow resistance is elevated by agents such as histamine.", "output": {"entities": {}}, "schema": []}
{"input": "DNA sequence and evolution of the CPS domain of the Syrian hamster multifunctional protein CAD.", "output": {"entities": {"gene": [{"text": "CPS domain", "start": 34, "end": 44}, {"text": "Syrian hamster multifunctional protein CAD", "start": 52, "end": 94}]}}, "schema": []}
{"input": "A high-frequency restriction fragment length polymorphism was evident in the DNA from 29 unrelated individuals using the enzyme BglII.", "output": {"entities": {"gene": [{"text": "BglII", "start": 128, "end": 133}]}}, "schema": []}
{"input": "The antilog transformation of pH did not improve the results.", "output": {"entities": {}}, "schema": []}
{"input": "Telomeres prevent end-to-end fusions and exonucleolytic degradation, enable the end of the linear DNA molecule to replicate, and function in cell division.", "output": {"entities": {}}, "schema": []}
{"input": "One of these is located in the 5'-untranslated region, and may encode regulatory sequences.", "output": {"entities": {}}, "schema": []}
{"input": "The native enzyme purified from protease-B-deficient URA2-transformed cells, was phosphorylated in vitro using catalytic subunits of pure cAMP-dependent protein kinase.", "output": {"entities": {"gene": [{"text": "protease-B", "start": 32, "end": 42}, {"text": "URA2", "start": 53, "end": 57}, {"text": "cAMP-dependent protein kinase", "start": 138, "end": 167}]}}, "schema": []}
{"input": "A bovine abomasum lambda gt11 cDNA library was screened with a monoclonal antibody raised against the rabbit H, K-ATPase beta subunit.", "output": {"entities": {"gene": [{"text": "rabbit H, K-ATPase beta subunit", "start": 102, "end": 133}]}}, "schema": []}
{"input": "Judicious use of laboratory testing, including monitoring of CD4 cell counts, is recommended.", "output": {"entities": {"gene": [{"text": "CD4", "start": 61, "end": 64}]}}, "schema": []}
{"input": "There is no TATA box appropriately spaced upstream from the transcription initiation site.", "output": {"entities": {}}, "schema": []}
{"input": "Characterization of the 5' end of the growth-regulated Syrian hamster CAD gene.", "output": {"entities": {"gene": [{"text": "Syrian hamster CAD gene", "start": 55, "end": 78}]}}, "schema": []}
{"input": "Early cirrhosis, an early modality of the evolution of acute hepatitis.", "output": {"entities": {}}, "schema": []}
{"input": "Combined therapy with MK-801 and nimodipine for protection of ischemic brain damage.", "output": {"entities": {}}, "schema": []}
{"input": "Initial screening of a rat liver cDNA library with an oligonucleotide probe derived from the rat SCP2 protein sequence revealed an 825-base pair cDNA clone coding for the complete SCP2 protein sequence.", "output": {"entities": {"gene": [{"text": "SCP2", "start": 97, "end": 101}, {"text": "SCP2", "start": 180, "end": 184}]}}, "schema": []}
{"input": "Cloning, expression, and nucleotide sequence of rat liver sterol carrier protein 2 cDNAs.", "output": {"entities": {"gene": [{"text": "rat liver sterol carrier protein 2 cDNAs", "start": 48, "end": 88}]}}, "schema": []}
{"input": "The addition of an equimolar complex of the fourth and seventh largest subunits, purified from pol II holoenzyme by ion-exchange chromatography in the presence of urea, restored promoter-directed initiation activity to pol II delta 4/7.", "output": {"entities": {"gene": [{"text": "pol II holoenzyme", "start": 95, "end": 112}, {"text": "pol II delta 4/7", "start": 219, "end": 235}]}}, "schema": []}
{"input": "We report here the identification of HSF in the fission yeast Schizosaccharomyces pombe.", "output": {"entities": {"gene": [{"text": "HSF", "start": 37, "end": 40}]}}, "schema": []}
{"input": "Induction requires the ACE1 gene product, which binds to specific sites in the promoter region of the CUP1 gene.", "output": {"entities": {"gene": [{"text": "ACE1 gene product", "start": 23, "end": 40}, {"text": "CUP1 gene", "start": 102, "end": 111}]}}, "schema": []}
{"input": "Gel mobility shift assays using a synthetic E6 motif detected a B-cell-specific complex in addition to a ubiquitous band found also in T cells and HeLa cells.", "output": {"entities": {"gene": [{"text": "E6 motif", "start": 44, "end": 52}]}}, "schema": []}
{"input": "The sequence of four clones was sufficient to construct a 3018-bp BAL cDNA structure.", "output": {"entities": {"gene": [{"text": "3018-bp BAL cDNA", "start": 58, "end": 74}]}}, "schema": []}
{"input": "The application of these instruments allows occlusion of the ascending aorta traversed by the perfusion cannula inserted directly or through the apex of the heart as well as simultaneous left ventricular venting.", "output": {"entities": {}}, "schema": []}
{"input": "Adenylosuccinate synthetase (IMP: L-aspartate ligase (GDP), EC 6. 3. 4. 4) plays an important role in purine biosynthesis catalyzing the GTP-dependent conversion of IMP to AMP.", "output": {"entities": {"gene": [{"text": "Adenylosuccinate synthetase", "start": 0, "end": 27}, {"text": "L-aspartate ligase", "start": 34, "end": 52}, {"text": "EC 6. 3. 4. 4", "start": 60, "end": 73}]}}, "schema": []}
{"input": "Immunophenotyping in four cases, demonstrated non-B, non-T cell origin in three and pre-B cell origin in one.", "output": {"entities": {}}, "schema": []}
{"input": "The results strengthen the conclusion that predominantly dynamic activity increases the G4 content of mature innervated fast muscles.", "output": {"entities": {"gene": [{"text": "G4", "start": 88, "end": 90}]}}, "schema": []}
{"input": "We reviewed the records of 151 patients with optic neuritis examined over an eight-year period.", "output": {"entities": {}}, "schema": []}
{"input": "Cut-off levels that define abnormality are rather arbitrary and this decreases the specificity of the test in apparently healthy patients.", "output": {"entities": {}}, "schema": []}
{"input": "Alanine aminotransferase in clinical practice.", "output": {"entities": {"gene": [{"text": "Alanine aminotransferase", "start": 0, "end": 24}]}}, "schema": []}
{"input": "Nucleotide sequence analysis of the Pseudomonas putida PpG7 salicylate hydroxylase gene (nahG) and its 3'-flanking region.", "output": {"entities": {"gene": [{"text": "Pseudomonas putida PpG7 salicylate hydroxylase gene", "start": 36, "end": 87}, {"text": "nahG", "start": 89, "end": 93}]}}, "schema": []}
{"input": "All six ARF cDNAs are more similar to each other than to other approximately 20-kDa guanine nucleotide-binding proteins.", "output": {"entities": {"gene": [{"text": "ARF cDNAs", "start": 8, "end": 17}, {"text": "20-kDa guanine nucleotide-binding proteins", "start": 77, "end": 119}]}}, "schema": []}
{"input": "The long terminal repeat (LTR) of the human immunodeficiency virus (HIV) contains three binding sites for the transcriptional factor Sp1.", "output": {"entities": {"gene": [{"text": "Sp1", "start": 133, "end": 136}]}}, "schema": []}
{"input": "DNA from PCR was labeled and used to isolate several lambda gt11 cDNA clones, including one full-length one (Dd kinase-2).", "output": {"entities": {"gene": [{"text": "Dd kinase-2", "start": 109, "end": 120}]}}, "schema": []}
{"input": "A.", "output": {"entities": {}}, "schema": []}
{"input": "Perilunar luxation--an unusual injury demanding immediate and correct treatment", "output": {"entities": {}}, "schema": []}
{"input": "Landsberg (La-O) and cv.", "output": {"entities": {}}, "schema": []}
{"input": "In summary, at equianesthetic concentrations, desflurane and isoflurane produced similar hemodynamic effects; however, in the absence of drugs that inhibit autonomic reflexes, desflurane had less negative inotropic activity and produced less decrease in arterial pressure.", "output": {"entities": {}}, "schema": []}
{"input": "We report here the isolation of a full-length cDNA clone coding for a hitherto undiscovered isoform of the bovine C-subunit.", "output": {"entities": {"gene": [{"text": "bovine C-subunit", "start": 107, "end": 123}]}}, "schema": []}
{"input": "Isoform C beta 2, an unusual form of the bovine catalytic subunit of cAMP-dependent protein kinase.", "output": {"entities": {"gene": [{"text": "Isoform C beta 2", "start": 0, "end": 16}, {"text": "cAMP-dependent protein kinase", "start": 69, "end": 98}]}}, "schema": []}
{"input": "Salient applications of PB-PK modeling to toxicological problems are illustrated with examples.", "output": {"entities": {}}, "schema": []}
{"input": "Patients with apparently minor CT abnormalities may have significant epidural disease.", "output": {"entities": {}}, "schema": []}
{"input": "The cdr1 sequence includes an additional 237 amino acids of the contiguous fragment and encodes a product of predicted Mr 67, 000.", "output": {"entities": {"gene": [{"text": "cdr1 sequence", "start": 4, "end": 17}]}}, "schema": []}
{"input": "Armed with a clear understanding of the pathophysiologic pathways that may cause and/or contribute to the development of unconjugated hyperbilirubinemia and the associated jaundice, the practitioner will be successful in helping the family understand their child' s illness.", "output": {"entities": {}}, "schema": []}
{"input": "Displacement thresholds of peripheral sites in monocular human vision were obtained.", "output": {"entities": {}}, "schema": []}
{"input": "The authors report a case in which stereotactic irrigation of a brain cyst was temporally associated with respiratory distress.", "output": {"entities": {}}, "schema": []}
{"input": "ELISA was found to make a contribution to the diagnosis of tuberculosis similar to that of sputum smear.", "output": {"entities": {}}, "schema": []}
{"input": "In this paper, we report a detailed study of the structure and the functional role of the MalT binding sites located in the adjacent and divergent pulAp and pulCp promoters.", "output": {"entities": {"gene": [{"text": "MalT binding sites", "start": 90, "end": 108}, {"text": "pulAp", "start": 147, "end": 152}, {"text": "pulCp promoters", "start": 157, "end": 172}]}}, "schema": []}
{"input": "Despite the small number of patients, on the basis of this report, we can confirm that 1. 5 MU/day of alpha-IFN is an adequate treatment for patients with hairy cell leukemia.", "output": {"entities": {"gene": [{"text": "alpha-IFN", "start": 102, "end": 111}]}}, "schema": []}
{"input": "Paroxysmal fluctuations in observed parasitemia in Plasmodium falciparum malaria.", "output": {"entities": {}}, "schema": []}
{"input": "No positive family history was obtained.", "output": {"entities": {}}, "schema": []}
{"input": "Occupational asthma and rhinoconjunctivitis from inhalation of crystalline bovine serum albumin powder.", "output": {"entities": {"gene": [{"text": "bovine serum albumin", "start": 75, "end": 95}]}}, "schema": []}
{"input": "A further subdivision of Category pN1 into pN1a (metastasis in single node) and pN1b (two or more nodes) is recommended.", "output": {"entities": {}}, "schema": []}
{"input": "Amino acid sequence comparisons of the E74A protein reveal a highly conserved C-terminal region that is rich in basic amino acid residues and which has been proposed to possess sequence-specific DNA binding activity.", "output": {"entities": {"gene": [{"text": "E74A protein", "start": 39, "end": 51}]}}, "schema": []}
{"input": "We found that the relative strengths of the promoters were similar in different contexts.", "output": {"entities": {}}, "schema": []}
{"input": "Grasso, and A.", "output": {"entities": {}}, "schema": []}
{"input": "After 6 months, definite improvement in strength occurred in 4 of 7 carnitine-treated patients and in none of 7 controls.", "output": {"entities": {}}, "schema": []}
{"input": "Age at POI and asymptote were achieved later for Line RBC2 than for Line F.", "output": {"entities": {}}, "schema": []}
{"input": "To identify the DNA sequences that cis-regulate the expression of the rat liver pyruvate kinase (L-PK) genes, a series of constructs in which the chloramphenicol acetyltransferase reporter genes is driven by various deleted fragments of the 3200 base pairs (bp) upstream of the L-PK gene cap site have been assayed for transient expression after introduction into hepatoma HepG2 cells, rat hepatocytes in primary culture, fibroblast LTK-cells, myogenic C2C12 cells, and CHO cells.", "output": {"entities": {"gene": [{"text": "rat liver pyruvate kinase", "start": 70, "end": 95}, {"text": "L-PK", "start": 97, "end": 101}, {"text": "chloramphenicol acetyltransferase reporter genes", "start": 146, "end": 194}, {"text": "L-PK gene cap site", "start": 278, "end": 296}]}}, "schema": []}
{"input": "The disturbance of pulmonary gas exchange, as revealed by the high value of AaDO2, existed without left ventricular dysfunction, and AaDO2 had no significant relationship with any of the hemodynamic parameters including the difference between plasma colloid osmotic pressure and PCW.", "output": {"entities": {}}, "schema": []}
{"input": "A dose of 3 and 6 micrograms/kg/day GM-CSF reduces the severity of neutropenia and thrombocytopenia after carboplatin-cyclophosphamide chemotherapy, which may lead to more effective chemotherapy for ovarian cancer in the future.", "output": {"entities": {"gene": [{"text": "GM-CSF", "start": 36, "end": 42}]}}, "schema": []}
{"input": "These differences involve specific hydrogen-bonding interactions between the protein and DNA, including guanine N7 sites in the major groove of DNA, and alterations in DNA phosphodiester conformation induced by protein binding.", "output": {"entities": {}}, "schema": []}
{"input": "Biochemical analysis demonstrates that the BJ1 protein is associated with nucleosomes and is released from chromatin by agents which intercalate into DNA, as previously shown for the high mobility group proteins (HMGs).", "output": {"entities": {"gene": [{"text": "BJ1 protein", "start": 43, "end": 54}, {"text": "high mobility group proteins", "start": 183, "end": 211}, {"text": "HMGs", "start": 213, "end": 217}]}}, "schema": []}
{"input": "I propose that their gene products bind to the chromatin to establish or maintain a proper higher order structure as a prerequisite for a regulated gene expression.", "output": {"entities": {}}, "schema": []}
{"input": "The C4BP alpha gene is organized as follows: the first exon codes for the first 198 nucleotides of the 5' UTR.", "output": {"entities": {"gene": [{"text": "C4BP alpha gene", "start": 4, "end": 19}]}}, "schema": []}
{"input": "The human immunodeficiency virus type 1 (HIV-1) Rev protein is a positive posttranscriptional regulator of viral structural gene expression and essential for virus replication.", "output": {"entities": {"gene": [{"text": "human immunodeficiency virus type 1 (HIV-1) Rev protein", "start": 4, "end": 59}]}}, "schema": []}
{"input": "The CDC7 gene has two in-frame AUG codons as possible translation start sites, which would produce 58-and 56-kDa proteins, respectively.", "output": {"entities": {"gene": [{"text": "CDC7 gene", "start": 4, "end": 13}]}}, "schema": []}
{"input": "Differences in the clinical presentation and the gross appearance of the two cases are described, and similarities in the microscopic features are discussed.", "output": {"entities": {}}, "schema": []}
{"input": "MEASUREMENTS AND MAIN RESULTS: The two groups were similar on entry into the study, including mean FEV1 measurements (0. 70 L atropine/0. 60 L metaproterenol, P greater than. 05).", "output": {"entities": {}}, "schema": []}
{"input": "Using an ELISA, we found that surfactant protein A (SP-A) was markedly elevated in the pneumonia patients.", "output": {"entities": {"gene": [{"text": "surfactant protein A", "start": 30, "end": 50}, {"text": "SP-A", "start": 52, "end": 56}]}}, "schema": []}
{"input": "In view of the short t1/2, we used three doses/day.", "output": {"entities": {}}, "schema": []}
{"input": "Temporal control of GUS expression was found to involve two negative regulatory sequences, NRS1 (-391 to-295) and NRS2 (-518 to-418), as well as the positive domain UAS1.", "output": {"entities": {"gene": [{"text": "GUS", "start": 20, "end": 23}]}}, "schema": []}
{"input": "We purified a Ca2 +/calmodulin (CaM)-dependent protein kinase (CaM kinase) from the yeast Saccharomyces cerevisiae with properties similar to mammalian type II CaM kinases.", "output": {"entities": {"gene": [{"text": "Ca2 +/calmodulin (CaM)-dependent protein kinase", "start": 14, "end": 61}, {"text": "CaM kinase", "start": 63, "end": 73}, {"text": "mammalian type II CaM kinases", "start": 142, "end": 171}]}}, "schema": []}
{"input": "In most cases, DR4-homozygous, DRB1-heterozygous individuals could be genotyped with the panel of probes.", "output": {"entities": {"gene": [{"text": "DR4", "start": 15, "end": 18}, {"text": "DRB1", "start": 31, "end": 35}]}}, "schema": []}
{"input": "The prevalence of opportunistic infection among surviving AIDS patients and the probability of being in tumour response following cancer therapy conditional on being alive are two examples of such functions.", "output": {"entities": {}}, "schema": []}
{"input": "Genomic clones encompassing the human ETS1 gene were isolated and utilized to define its molecular organization.", "output": {"entities": {"gene": [{"text": "human ETS1 gene", "start": 32, "end": 47}]}}, "schema": []}
{"input": "Polymerase chain reaction analysis of ETS1 cDNA identified several amplified products, indicating alternative splicing.", "output": {"entities": {"gene": [{"text": "ETS1 cDNA", "start": 38, "end": 47}]}}, "schema": []}
{"input": "Most of the expressed human E3 polypeptides (five bands) were found in the insoluble pellet while primarily full-length mature E3 was found in the soluble fraction.", "output": {"entities": {"gene": [{"text": "human E3 polypeptides", "start": 22, "end": 43}, {"text": "full-length mature E3", "start": 108, "end": 129}]}}, "schema": []}
{"input": "To test promotor function, chimeric genes were constructed linking fragments of chicken IGF-I 5'-flanking DNA to a promoterless reporter plasmid.", "output": {"entities": {"gene": [{"text": "IGF-I", "start": 88, "end": 93}]}}, "schema": []}
{"input": "The alpha 4 gene 5' flanking region acted as a promoter in transfection assays.", "output": {"entities": {"gene": [{"text": "alpha 4 gene", "start": 4, "end": 16}]}}, "schema": []}
{"input": "Characterization of the alpha 4 integrin gene promoter.", "output": {"entities": {"gene": [{"text": "alpha 4 integrin gene promoter", "start": 24, "end": 54}]}}, "schema": []}
{"input": "Only the 3. 0-kb transcript was detected in adult tissues, where its expression was restricted almost exclusively to the central nervous system.", "output": {"entities": {}}, "schema": []}
{"input": "Two homologues of the rhombotin gene have now been isolated.", "output": {"entities": {"gene": [{"text": "rhombotin gene", "start": 22, "end": 36}]}}, "schema": []}
{"input": "Angina haemorrhagica bullosa causing respiratory obstruction postoperatively.", "output": {"entities": {}}, "schema": []}
{"input": "We examined the effects of long-term perfusion with pyridoxalated hemoglobin polyoxyethylene conjugate (PHP) solution on cardiac function of isolated rat hearts.", "output": {"entities": {"gene": [{"text": "hemoglobin", "start": 66, "end": 76}]}}, "schema": []}
{"input": "The gcd2-503 mutation also results in polysome runoff, accumulation of inactive 80S ribosomal couples, and accumulation of at least one of the subunits of the general translation initiation factor 2 (eIF-2 alpha) in 43S-48S particles following a shift to the restrictive temperature.", "output": {"entities": {"gene": [{"text": "gcd2-503", "start": 4, "end": 12}, {"text": "80S ribosomal couples", "start": 80, "end": 101}, {"text": "general translation initiation factor 2", "start": 159, "end": 198}, {"text": "eIF-2 alpha", "start": 200, "end": 211}, {"text": "43S", "start": 216, "end": 219}, {"text": "48S", "start": 220, "end": 223}]}}, "schema": []}
{"input": "Eight patients with ARC and renal failure were recently evaluated.", "output": {"entities": {}}, "schema": []}
{"input": "To measure the enhancer activity of DR60, a reporter plasmid was constructed that contained DR60 cloned upstream of the reporter chloramphenicol acetyltransferase gene under the control of the delayed-early 39K promoter.", "output": {"entities": {"gene": [{"text": "DR60", "start": 36, "end": 40}, {"text": "DR60", "start": 92, "end": 96}, {"text": "chloramphenicol acetyltransferase gene", "start": 129, "end": 167}]}}, "schema": []}
{"input": "A single case of an adenocarcinoma, arising in a retroperitoneal enterogenous cyst and which presented as a left renal cyst, is reported.", "output": {"entities": {}}, "schema": []}
{"input": "Using the polymerase chain reaction, we analyzed the U6 RNA genes of 52 organisms.", "output": {"entities": {"gene": [{"text": "U6 RNA genes", "start": 53, "end": 65}]}}, "schema": []}
{"input": "Both tear volume and tear flow were found to be significantly (P less than 0. 001) decreased up to 6 h after instillation, reaching a minimum 90 min after application (tear volume:-63%; tear flow:-71%).", "output": {"entities": {}}, "schema": []}
{"input": "Hydrophobicity analysis indicated that the KlaA and KlaB polypeptides are likely to be soluble, whereas the KlaC polypeptide was predicted to have four potential membrane-spanning domains.", "output": {"entities": {"gene": [{"text": "KlaA", "start": 43, "end": 47}, {"text": "KlaB polypeptides", "start": 52, "end": 69}, {"text": "KlaC polypeptide", "start": 108, "end": 124}]}}, "schema": []}
{"input": "To facilitate the availability of important new therapeutic agents, the Food and Drug Administration (FDA) in the mid-1970s began assigning therapeutic ratings to investigational new drugs and holding end-of-phase II conferences with drug sponsors.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast, similar rates of B. sphaericus products, ABG-6184 technical powder and BSP-2 flowable concentrate, produced no significant reduction.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, the DNA polymerase II complex was difficult to obtain from dpb2-1 mutant cells, suggesting that a stable DNA polymerase II complex requires DPB2 and is essential for chromosomal replication.", "output": {"entities": {"gene": [{"text": "DNA polymerase II complex", "start": 17, "end": 42}, {"text": "dpb2-1", "start": 72, "end": 78}, {"text": "DNA polymerase II complex", "start": 118, "end": 143}, {"text": "DPB2", "start": 153, "end": 157}]}}, "schema": []}
{"input": "To determine whether mononuclear cell secretory products contribute to the changes in bone turnover that characterize the development of postmenopausal osteoporosis, we evaluated the effects of oophorectomy and subsequent estrogen replacement on the spontaneous secretion of interleukin 1 (IL-1) and tumor necrosis factor alpha (TNF-alpha) and on the phytohemagglutinin A-induced secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) from peripheral blood mononuclear cells.", "output": {"entities": {"gene": [{"text": "interleukin 1", "start": 275, "end": 288}, {"text": "IL-1", "start": 290, "end": 294}, {"text": "tumor necrosis factor alpha", "start": 300, "end": 327}, {"text": "TNF-alpha", "start": 329, "end": 338}, {"text": "phytohemagglutinin A", "start": 351, "end": 371}, {"text": "granulocyte-macrophage colony-stimulating factor", "start": 393, "end": 441}, {"text": "GM-CSF", "start": 443, "end": 449}]}}, "schema": []}
{"input": "There were 45 to 56 nt differences between the virulent and avirulent groups while there were 6 to 14 nt differences among four avirulent strains.", "output": {"entities": {}}, "schema": []}
{"input": "The standard principles of surgical management must be adhered to when using Sandostatin to treat patients with these disorders.", "output": {"entities": {}}, "schema": []}
{"input": "Some of the PCR products contained mutations in ATG1 and/or ATG2.", "output": {"entities": {"gene": [{"text": "ATG1", "start": 48, "end": 52}, {"text": "ATG2", "start": 60, "end": 64}]}}, "schema": []}
{"input": "These data suggest that the levels of oxygen free radicals were increased in hepatocytes and mitochondria.", "output": {"entities": {}}, "schema": []}
{"input": "The sequence of the pMxL1 plasmid containing the invertible region contains a perfect tandem repeat of 19 bp in the orientation 1 nonexpressed pilin gene at the middle of the recombination junction site.", "output": {"entities": {"gene": [{"text": "pilin gene", "start": 143, "end": 153}]}}, "schema": []}
{"input": "No evidence for the presence of introns within the acvA gene has been found.", "output": {"entities": {"gene": [{"text": "acvA gene", "start": 51, "end": 60}]}}, "schema": []}
{"input": "These observations, together with the occurrence of putative 4'-phosphopantetheine-attachment sites and a putative thioesterase site, are discussed with reference to the reaction sequence leading to production of the ACV tripeptide.", "output": {"entities": {"gene": [{"text": "thioesterase site", "start": 115, "end": 132}, {"text": "ACV tripeptide", "start": 217, "end": 231}]}}, "schema": []}
{"input": "Pargyline, a monoamine oxidase inhibitor, reduces peak 3 transiently (max.", "output": {"entities": {"gene": [{"text": "monoamine oxidase", "start": 13, "end": 30}]}}, "schema": []}
{"input": "When given the choice between an estrous female and a sexually active male in the AOF, flutamide females, as well as controls, preferred the male partner.", "output": {"entities": {}}, "schema": []}
{"input": "Hypoxic ventilatory responses were-1. 99 +/-0. 37 L/min/% SaO2 in the relatives and-1. 54 +/-0. 25 L/min/% SaO2 in the control subjects. (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {}}, "schema": []}
{"input": "Very small deletions within the conserved region completely abolished transforming activity of dbl, while extensive deletion outside of this region had no effect.", "output": {"entities": {"gene": [{"text": "dbl", "start": 95, "end": 98}]}}, "schema": []}
{"input": "This computerized list was linked to the central files of the Massachusetts Cancer Registry and cases diagnosed between 1982 and 1988 were identified.", "output": {"entities": {}}, "schema": []}
{"input": "We also present evidence for a negative regulatory element in the 5' flanking region of the Mlu I upstream activation sequence.", "output": {"entities": {"gene": [{"text": "Mlu I upstream activation sequence", "start": 92, "end": 126}]}}, "schema": []}
{"input": "Mechanism of activation of the vav protooncogene. vav is a human locus that appears to be specifically expressed in cells of hematopoietic origin regardless of their differentiation lineage.", "output": {"entities": {"gene": [{"text": "vav protooncogene", "start": 31, "end": 48}, {"text": "vav", "start": 50, "end": 53}]}}, "schema": []}
{"input": "Endothelial cell seeding.", "output": {"entities": {}}, "schema": []}
{"input": "Menetrier disease in a child.", "output": {"entities": {}}, "schema": []}
{"input": "After hemodynamic stabilization, the goal of therapy is to diminish the chance that an ulcer will continue to bleed or will rebleed.", "output": {"entities": {}}, "schema": []}
{"input": "Thirty seven patients (amitriptyline n = 16, moclobemide n = 21) completed the six week protocol, which was conducted under double blind conditions.", "output": {"entities": {}}, "schema": []}
{"input": "The stimulus threshold for EER showed a less individual variation than amplitude.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of electrically evoked response (EER) in relation to the central visual pathway of the cat (1).", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, plasma fibrinogen levels increased by a mean of 17. 6%, a potentially adverse effect of gemfibrozil that has not been previously reported.", "output": {"entities": {"gene": [{"text": "fibrinogen", "start": 20, "end": 30}]}}, "schema": []}
{"input": "Gemfibrozil in hyperlipidaemic patients with peripheral arterial disease: some undiscovered actions.", "output": {"entities": {}}, "schema": []}
{"input": "An RME1-independent pathway for sporulation control in Saccharomyces cerevisiae acts through IME1 transcript accumulation.", "output": {"entities": {"gene": [{"text": "RME1", "start": 3, "end": 7}, {"text": "IME1 transcript", "start": 93, "end": 108}]}}, "schema": []}
{"input": "The role of pharmacological profiling in safety assessment.", "output": {"entities": {}}, "schema": []}
{"input": "Its application in Madagascar: advantages and disadvantages", "output": {"entities": {}}, "schema": []}
{"input": "The authors evaluate the clinical efficacy of EMB AZS in recurrent ulcer after operation on the stomach caused by a high level of acid production and ulcerative gastroduodenal bleeding.", "output": {"entities": {}}, "schema": []}
{"input": "To investigate the regulation of Spec gene activity, the region around the Spec1 transcriptional initiation site was analyzed for sites of protein-DNA interaction.", "output": {"entities": {"gene": [{"text": "Spec gene", "start": 33, "end": 42}, {"text": "Spec1 transcriptional initiation site", "start": 75, "end": 112}]}}, "schema": []}
{"input": "Phosphopeptide mapping revealed the same autophosphorylation sites utilized by EGFR-IC as those identified in wild-type EGFR.", "output": {"entities": {"gene": [{"text": "EGFR-IC", "start": 79, "end": 86}, {"text": "wild-type EGFR", "start": 110, "end": 124}]}}, "schema": []}
{"input": "The encoded sequence revealed a typical signal peptide, a predominantly hydrophilic 707 amino acid residue domain with 8 N-glycosylation sites, a transmembrane domain, and a C-terminal domain of 52 amino acids.", "output": {"entities": {}}, "schema": []}
{"input": "The TCF-1 alpha binding site was also required for TCR alpha enhancer activity in transcriptionally active extracts from Jurkat but not HeLa cells, confirming that TCF-1 alpha is a T-cell-specific transcription factor.", "output": {"entities": {"gene": [{"text": "TCF-1 alpha binding site", "start": 4, "end": 28}, {"text": "TCR alpha enhancer", "start": 51, "end": 69}, {"text": "TCF-1 alpha", "start": 164, "end": 175}, {"text": "T-cell-specific transcription factor", "start": 181, "end": 217}]}}, "schema": []}
{"input": "A new semi-automatic method for quantifying regional cerebral uptake of 99m technetium-hexamethylpropylene amine oxime (99mTc-HMPAO) was used to assess single photon emission tomograms from 5 normal subjects, 14 patients with Alzheimer' s disease, 14 patients with dementia of frontal lobe type and 4 patients with dementia with motor neurone disease.", "output": {"entities": {}}, "schema": []}
{"input": "The results showed that fog, up to a level of base plus fog of 0. 6 optical density units, had no influence on the diagnostic accuracy in the absence of any compensation.", "output": {"entities": {}}, "schema": []}
{"input": "IdB 1031 was first extracted by liquid-solid partition and the extracts were evaporated and analysed on a reversed-phase column under isocratic conditions, using either an electrochemical or a UV detector.", "output": {"entities": {}}, "schema": []}
{"input": "In this model, eltoprazine has a very specific anti-aggressive (serenic) profile, inhibiting aggression while social interaction and exploration are not decreased but even enhanced; inactivity, a measure for sedation, is not affected.", "output": {"entities": {}}, "schema": []}
{"input": "A new method for the in vitro transfer of delayed hypersensitivity by dialysed transfer factor.", "output": {"entities": {"gene": [{"text": "transfer factor", "start": 79, "end": 94}]}}, "schema": []}
{"input": "Effect of separate and combined effects of plutonium-239, hexachlorobutadiene and tributyl phosphate on the thymus gland of rats", "output": {"entities": {}}, "schema": []}
{"input": "Data collection was made with a query language, and data analysis performed with an interactive knowledge-based statistical tool, MAXITAB, employing a multivariate tabular analysis technique.", "output": {"entities": {}}, "schema": []}
{"input": "ARPIA has been implemented by using a relational DBMS, very cheap and highly diffused on personal computers.", "output": {"entities": {}}, "schema": []}
{"input": "Diuresis was induced by scheduled drinking of tea (150 ml/h).", "output": {"entities": {}}, "schema": []}
{"input": "Diagnostic value of adenosine deaminase activity in tuberculous effusions.", "output": {"entities": {"gene": [{"text": "adenosine deaminase", "start": 20, "end": 39}]}}, "schema": []}
{"input": "Femoral strain adaptation after total hip replacement: a comparison of cemented and porous ingrowth components in canines.", "output": {"entities": {}}, "schema": []}
{"input": "Immuno-cytochemistry, using antisera against Campylobacter jejuni, showed that the positive staining in altered epithelial cells were restricted to intracellular organisms having a structure resembling Campylobacter spp.", "output": {"entities": {}}, "schema": []}
{"input": "Promoter activities were estimated using beta-glucuronidase and neomycin phosphotransferase II reporter gene systems.", "output": {"entities": {"gene": [{"text": "beta-glucuronidase", "start": 41, "end": 59}, {"text": "neomycin phosphotransferase II reporter gene systems", "start": 64, "end": 116}]}}, "schema": []}
{"input": "The 5' regions of these two soybean actin genes contain many unusual features including (CT) repeats and long stretches of pyrimidine-rich DNA.", "output": {"entities": {"gene": [{"text": "soybean actin genes", "start": 28, "end": 47}]}}, "schema": []}
{"input": "All 8 (100%) patients with fulminant hepatic failure who received grafts survived, including 3 who received ABO-incompatible grafts, though 2 of these subsequently required retransplantation.", "output": {"entities": {}}, "schema": []}
{"input": "No patient had a history of excess alcohol intake, or prolonged intake of hepatotoxic drugs and steroids, and were not obese or malnourished.", "output": {"entities": {}}, "schema": []}
{"input": "An evolutionary comparison of amino acid sequences of 34 HSP70 proteins from 17 species suggests that BiP genes share a common ancestor, which diverged from other HSP70 genes near the time when eukaryotes first appeared.", "output": {"entities": {"gene": [{"text": "HSP70 proteins", "start": 57, "end": 71}, {"text": "BiP genes", "start": 102, "end": 111}, {"text": "HSP70 genes", "start": 163, "end": 174}]}}, "schema": []}
{"input": "Spore inocula (approximately 10 (6)/coupon) were dried onto 0. 5-in.", "output": {"entities": {}}, "schema": []}
{"input": "However, overexpression of both the STE4 and STE18 proteins did not generate a stronger pheromone response than overexpression of STE4 in the presence of wild-type levels of STE18.", "output": {"entities": {"gene": [{"text": "STE4", "start": 36, "end": 40}, {"text": "STE18 proteins", "start": 45, "end": 59}, {"text": "STE4", "start": 130, "end": 134}, {"text": "STE18", "start": 174, "end": 179}]}}, "schema": []}
{"input": "Reverse transcription-PCR was then used to clone from human poly (A) + RNA the cDNA corresponding to the expressed homolog of psi ARF 4, referred to as human ARF 4.", "output": {"entities": {"gene": [{"text": "psi ARF 4", "start": 126, "end": 135}, {"text": "human ARF 4", "start": 152, "end": 163}]}}, "schema": []}
{"input": "To evaluate the cost and benefits of screening tests for Chlamydia trachomatis in adolescent males, we developed a decision analysis model and compared the leukocyte esterase urine dipstick test with culture, with direct-smear fluorescent antibody (DFA), and with the option of no screening (no treatment).", "output": {"entities": {"gene": [{"text": "leukocyte esterase", "start": 156, "end": 174}]}}, "schema": []}
{"input": "Sequencing the gene for an imipenem-cefoxitin-hydrolyzing enzyme (CfiA) from Bacteroides fragilis TAL2480 reveals strong similarity between CfiA and Bacillus cereus beta-lactamase II.", "output": {"entities": {"gene": [{"text": "CfiA", "start": 66, "end": 70}, {"text": "CfiA", "start": 140, "end": 144}, {"text": "Bacillus cereus beta-lactamase II", "start": 149, "end": 182}]}}, "schema": []}
{"input": "The cloned HindIII fragment, which was shown by DNA sequence analysis to encode the N-terminal half of the B. subtilis IF2 protein and 0. 2 kb of upstream flanking sequence, was utilized as a homologous probe to clone an overlapping 2. 76-kb ClaI chromosomal fragment containing the entire IF2 structural gene.", "output": {"entities": {"gene": [{"text": "HindIII fragment", "start": 11, "end": 27}, {"text": "B. subtilis IF2 protein", "start": 107, "end": 130}, {"text": "2. 76-kb ClaI chromosomal fragment", "start": 233, "end": 267}, {"text": "entire IF2 structural gene", "start": 283, "end": 309}]}}, "schema": []}
{"input": "Maternal seizures had occurred during pregnancy in 52 per cent.", "output": {"entities": {}}, "schema": []}
{"input": "It encodes a protein with three zinc fingers similar to those of the transcription factor Sp1.", "output": {"entities": {"gene": [{"text": "transcription factor Sp1", "start": 69, "end": 93}]}}, "schema": []}
{"input": "Krox-24 is therefore a sequence-specific transcriptional activator.", "output": {"entities": {"gene": [{"text": "Krox-24", "start": 0, "end": 7}]}}, "schema": []}
{"input": "The interindividual variability of the parameters is taken into consideration by interactively determining the threshold levels.", "output": {"entities": {}}, "schema": []}
{"input": "Inspired CO2 causing changes from hypo-to normocapnia has previously been shown to improve arterial O2 tension (PaO2) and to reduce alveolar-arterial O2 difference.", "output": {"entities": {}}, "schema": []}
{"input": "Expression, nucleotide sequence and mutational analysis of two open reading frames in the nif gene region of Anabaena sp. strain PCC7120.", "output": {"entities": {"gene": [{"text": "nif gene region of Anabaena sp. strain PCC7120", "start": 90, "end": 136}]}}, "schema": []}
{"input": "Our results suggest that a sequence match between enhancers and certain promoter elements is critical.", "output": {"entities": {}}, "schema": []}
{"input": "This Mr is similar to those of the purified smg p25A GDI estimated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and sucrose density gradient ultracentrifugation, which are about 54, 000 and 65, 000, respectively.", "output": {"entities": {"gene": [{"text": "purified smg p25A GDI", "start": 35, "end": 56}]}}, "schema": []}
{"input": "Yeast mutants assigned to the pet complementation group G104 were found to lack alpha-ketoglutarate dehydrogenase activity as a result of mutations in the dihydrolipoyl transsuccinylase (KE2) component of the complex.", "output": {"entities": {"gene": [{"text": "pet", "start": 30, "end": 33}, {"text": "alpha-ketoglutarate dehydrogenase", "start": 80, "end": 113}, {"text": "dihydrolipoyl transsuccinylase", "start": 155, "end": 185}, {"text": "KE2", "start": 187, "end": 190}]}}, "schema": []}
{"input": "Critical residues required for repression are located within the C-terminal 27 amino acids of c-Fos, since v-Fos and C-terminal truncations of c-Fos did not down regulate.", "output": {"entities": {"gene": [{"text": "c-Fos", "start": 94, "end": 99}, {"text": "v-Fos", "start": 107, "end": 112}, {"text": "c-Fos", "start": 143, "end": 148}]}}, "schema": []}
{"input": "We also discovered a V lambda pseudogene, called psi V lambda 1, 3 kb upstream of the U266 lambda gene.", "output": {"entities": {"gene": [{"text": "V lambda pseudogene", "start": 21, "end": 40}, {"text": "psi V lambda 1", "start": 49, "end": 63}, {"text": "U266 lambda gene", "start": 86, "end": 102}]}}, "schema": []}
{"input": "In this paper, we have analyzed the structure of human gene for Gx alpha, which spans more than 60 kilobases.", "output": {"entities": {"gene": [{"text": "Gx alpha", "start": 64, "end": 72}]}}, "schema": []}
{"input": "A long follow-up study revealed that convalescent stage children still have the potency to have an immediate type hypersensitivity reaction on exposure to mite antigen, with a high titer of mite specific IgE in their sera, but they are free from asthmatic attacks because of the reduction in the amount of mite antigen in the body, as shown by the reduction in the amount of mite specific IgG.", "output": {"entities": {"gene": [{"text": "mite specific IgE", "start": 190, "end": 207}, {"text": "mite specific IgG", "start": 375, "end": 392}]}}, "schema": []}
{"input": "But no influence was observed at lower concentrations than 1/4 MIC of AMK.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, we notice two potential consensus motifs which are also found in corresponding positions in the genes for the nerve growth factor receptor and the 68-kDa neurofilament protein.", "output": {"entities": {"gene": [{"text": "nerve growth factor receptor", "start": 123, "end": 151}, {"text": "68-kDa neurofilament protein", "start": 160, "end": 188}]}}, "schema": []}
{"input": "In addition, the-119 to-81 fragment of the CCK promoter contains a transcriptional enhancer that potentiates the transcription from the herpes simplex virus thymidine kinase promoter in a position-and orientation-independent manner.", "output": {"entities": {"gene": [{"text": "CCK promoter", "start": 43, "end": 55}, {"text": "thymidine kinase promoter", "start": 157, "end": 182}]}}, "schema": []}
{"input": "Thirty minutes of supine restraint decreased DOPAC concentrations in the median eminence of female rats that were not exposed to ether, and brief exposure to ether enhanced this effect.", "output": {"entities": {}}, "schema": []}
{"input": "Influence of metoprolol treatment on sympatho-adrenal activation of fibrinolysis.", "output": {"entities": {}}, "schema": []}
{"input": "Five of 10 scars studied decreased at least 50% in linear dimensions.", "output": {"entities": {}}, "schema": []}
{"input": "Managing dysphagia in a chronic care setting: an introduction.", "output": {"entities": {}}, "schema": []}
{"input": "Gel-mobility-shift assays confirmed that the Raji nuclear proteins that bound to W and V elements were competed with by an HLA-DRA X-box oligonucleotide.", "output": {"entities": {"gene": [{"text": "HLA-DRA X-box oligonucleotide", "start": 123, "end": 152}]}}, "schema": []}
{"input": "The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins.", "output": {"entities": {"gene": [{"text": "NF1 locus", "start": 4, "end": 13}, {"text": "mammalian GAP", "start": 56, "end": 69}, {"text": "yeast IRA proteins", "start": 74, "end": 92}]}}, "schema": []}
{"input": "A second isotype of Raja immunoglobulin heavy chain genes has been detected by screening a spleen cDNA library with homologous Raja VH-and CH1-specific probes complementing the respective regions of the mu-like isotype.", "output": {"entities": {"gene": [{"text": "Raja immunoglobulin heavy chain genes", "start": 20, "end": 57}, {"text": "Raja VH", "start": 127, "end": 134}, {"text": "CH1", "start": 139, "end": 142}, {"text": "mu-like isotype", "start": 203, "end": 218}]}}, "schema": []}
{"input": "Petko, and S.", "output": {"entities": {}}, "schema": []}
{"input": "Disruption of ARF2 causes no detectable phenotype.", "output": {"entities": {"gene": [{"text": "ARF2", "start": 14, "end": 18}]}}, "schema": []}
{"input": "Human recombinant DNA-derived antihemophilic factor (factor VIII) in the treatment of hemophilia A. recombinant Factor VIII Study Group.", "output": {"entities": {"gene": [{"text": "antihemophilic factor", "start": 30, "end": 51}, {"text": "factor VIII", "start": 53, "end": 64}, {"text": "Factor VIII", "start": 112, "end": 123}]}}, "schema": []}
{"input": "Like other members of this family, the AP-4 HLH motif and the adjacent basic domain are necessary and sufficient to confer site-specific DNA binding.", "output": {"entities": {"gene": [{"text": "AP-4", "start": 39, "end": 43}]}}, "schema": []}
{"input": "Furthermore, expression of the promoter in embryonic Drosophila melanogaster cells that lack MyoD1 and Sp1 is strictly dependent on all three sites remaining intact and on the presence of exogenously supplied Sp1 and MyoD1.", "output": {"entities": {"gene": [{"text": "MyoD1", "start": 93, "end": 98}, {"text": "Sp1", "start": 103, "end": 106}, {"text": "Sp1", "start": 209, "end": 212}, {"text": "MyoD1", "start": 217, "end": 222}]}}, "schema": []}
{"input": "Effects of a selective monoamine oxidase (MAO)--A inhibitor, clorgyline, a selective MAO-B inhibitor, deprenyl, and a non-selective MAO inhibitor, nialamide, were investigated on footshock-induced aggression (FIA) in paired rats.", "output": {"entities": {"gene": [{"text": "monoamine oxidase (MAO)--A", "start": 23, "end": 49}, {"text": "MAO-B", "start": 85, "end": 90}, {"text": "MAO", "start": 132, "end": 135}]}}, "schema": []}
{"input": "To identify structural features of residues flanking the c-region that influence the fidelity and efficiency of signal peptidase cleavage as well as co-translational translocation, we introduced six amino acid substitutions into the COOH terminus of the hydrophobic core and seven substitutions at the NH2 terminus of the mature region (the + 1 position) of a model eukaryotic preprotein-human pre (delta pro) apoA-II.", "output": {"entities": {"gene": [{"text": "eukaryotic preprotein-human pre (delta pro) apoA-II", "start": 366, "end": 417}]}}, "schema": []}
{"input": "Additionally, although c-fos and egr-1 mRNAs are expressed at elevated levels in stimulated liver cells, fos-B, fra-1, and egr-2 are not, which suggests that factors in addition to the serum response factor participate in the regulation of immediate-early gene induction.", "output": {"entities": {"gene": [{"text": "c-fos", "start": 23, "end": 28}, {"text": "egr-1 mRNAs", "start": 33, "end": 44}, {"text": "fos-B", "start": 105, "end": 110}, {"text": "fra-1", "start": 112, "end": 117}, {"text": "egr-2", "start": 123, "end": 128}, {"text": "serum response factor", "start": 185, "end": 206}, {"text": "immediate-early gene", "start": 240, "end": 260}]}}, "schema": []}
{"input": "Of 848 patients, 819 cases with complete description of patient' s background were evaluable: Group A (surgery + MMC + 5-FU: chemotherapy) 253 cases, group B (surgery + MMC + 5-FU + OK-432 or PSK: immunochemotherapy) 282 and group C (surgery alone) 284.", "output": {"entities": {}}, "schema": []}
{"input": "The nuclear proteins encoded by the c-fos and c-jun protooncogenes are expressed during the proliferation period of osteoblast phenotype development.", "output": {"entities": {"gene": [{"text": "c-fos", "start": 36, "end": 41}, {"text": "c-jun protooncogenes", "start": 46, "end": 66}]}}, "schema": []}
{"input": "This model is further supported by binding of the Fos-Jun complex at an AP-1 site in the type alpha I collagen promoter that is contiguous with, but not overlapping, the VDRE.", "output": {"entities": {"gene": [{"text": "Fos", "start": 50, "end": 53}, {"text": "Jun", "start": 54, "end": 57}, {"text": "AP-1 site", "start": 72, "end": 81}, {"text": "type alpha I collagen promoter", "start": 89, "end": 119}]}}, "schema": []}
{"input": "PBSX is induced by agents which elicit the SOS response.", "output": {"entities": {"gene": [{"text": "PBSX", "start": 0, "end": 4}]}}, "schema": []}
{"input": "A bacteriological relapse requiring treatment occurred by 5 years in 16. 8% of 113 R3, 5. 2% of 97 R5, and 20. 0% of 115 Z5 patients with organisms sensitive to streptomycin and isoniazid initially.", "output": {"entities": {}}, "schema": []}
{"input": "In the controls, it was found that all right-handed and 10 out of 14 left-handed control subjects showed a right VHF (i. e., left hemisphere) advantage.", "output": {"entities": {}}, "schema": []}
{"input": "Although no Rh-antibodies were demonstrable, a similar mechanism can be postulated for the Rh-system.", "output": {"entities": {"gene": [{"text": "Rh-antibodies", "start": 12, "end": 25}]}}, "schema": []}
{"input": "This study was performed to clarify the location of a transesophageal echocardiographic (TEE) transducer when obtaining the short-axis view of the left ventricle (S-LV).", "output": {"entities": {}}, "schema": []}
{"input": "From S3 (CBF: 79-60%) to S5 (CBF: 39-0%),% WTh, 1/TPC and 1/T were significantly decreased from those of the control levels (all p less than 0. 01).", "output": {"entities": {}}, "schema": []}
{"input": "In that case, the ratio of brush abrasion was 0. 268, compressive and transverse strength, 124. 3 and 86. 3 MPa respectively, hardness, 43. 2 Hk, water absorption 14. 2 micrograms/mm3 and thermal expansion coefficient, 47. 4 x 10 (-6)/degrees C.", "output": {"entities": {}}, "schema": []}
{"input": "9, 1498-1506).", "output": {"entities": {}}, "schema": []}
{"input": "In a highly select group of stable hypertensive patients, we have assessed the strength of association between various blood pressure measurements (24 h average automated ambulatory blood pressure, 4 h automated ambulatory morning average blood pressure, multiple office visit average blood pressure, and a single office visit average blood pressure) and various echocardiographic indices of hypertensive cardiac target organ damage (left atrial diameter, left ventricular end diastolic diameter, posterior wall thickness, combined wall thickness, relative wall thickness, left ventricular mass and mass index, and combined wall thickness/left ventricular diastolic diameter ratio).", "output": {"entities": {}}, "schema": []}
{"input": "The p36 gene is at least 22 kb in length and has a coding sequence of approximately 1 kb, representing only 4. 5% of the gene. (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {"gene": [{"text": "p36 gene", "start": 4, "end": 12}]}}, "schema": []}
{"input": "This multimodality treatment for locally advanced gynecologic tumors appears feasible with modification, and continued work exploring this approach is encouraged.", "output": {"entities": {}}, "schema": []}
{"input": "With the modified fingertip-to-floor (MFTF) method, patients stand on a stool and forward bend so that measurements can be taken on patients who are able to touch the floor or reach beyond the level of the floor.", "output": {"entities": {}}, "schema": []}
{"input": "No significant differences could be seen in response rates according to the concentration of estrogen receptors or presence of progesteron receptors in this group of patients.", "output": {"entities": {"gene": [{"text": "estrogen receptors", "start": 93, "end": 111}, {"text": "progesteron receptors", "start": 127, "end": 148}]}}, "schema": []}
{"input": "Teicoplanin was given most often because of persistent fever or initial Gram-positive bacteraemia and only one-third of these cases responded.", "output": {"entities": {}}, "schema": []}
{"input": "In Experiments 1 and 2, infants, like adults, initially categorized novel objects on the basis of physical appearance, but only if trained with multiple exemplars, after delays of 1 and 7 days.", "output": {"entities": {}}, "schema": []}
{"input": "The clinical picture of the disease was significantly different from anthropogenic cutaneous leishmaniasis caused by L. tropica but similar to cutaneous patterns caused by L. infantum which was a prevalent pattern in the southern France.", "output": {"entities": {}}, "schema": []}
{"input": "In comparison with the 16 introns reported in AHA3, AHA2 is missing one intron in the 5'-untranslated region and a second intron in the C-terminal coding region.", "output": {"entities": {"gene": [{"text": "AHA3", "start": 46, "end": 50}, {"text": "AHA2", "start": 52, "end": 56}]}}, "schema": []}
{"input": "Northern blot analysis indicates that AHA2 mRNA relative to total cellular RNA is expressed at significantly higher levels in root tissue as compared with shoot tissue.", "output": {"entities": {"gene": [{"text": "AHA2 mRNA", "start": 38, "end": 47}]}}, "schema": []}
{"input": "Impaction of gastrostomy tube in the abdominal wall.", "output": {"entities": {}}, "schema": []}
{"input": "Both antidepressants elevated the pain threshold acutely, while pretreatment with pCPA largely blocked the analgesia.", "output": {"entities": {}}, "schema": []}
{"input": "Sci.", "output": {"entities": {}}, "schema": []}
{"input": "A needs assessment of these families was also done.", "output": {"entities": {}}, "schema": []}
{"input": "TCR alpha and beta gene expression may be regulated by a common set of T-cell nuclear proteins in that the T beta 2 element binding a set of cyclic AMP response element-binding proteins that are also bound by the T alpha 1 element of the human TCR alpha enhancer and the decamer element present in a large number of human and murine TCR beta promoters.", "output": {"entities": {"gene": [{"text": "TCR alpha and beta gene", "start": 0, "end": 23}, {"text": "T-cell nuclear proteins", "start": 71, "end": 94}, {"text": "T beta 2 element", "start": 107, "end": 123}, {"text": "cyclic AMP response element-binding proteins", "start": 141, "end": 185}, {"text": "T alpha 1 element", "start": 213, "end": 230}, {"text": "TCR alpha", "start": 244, "end": 253}, {"text": "TCR beta", "start": 333, "end": 341}]}}, "schema": []}
{"input": "The 3' stem-loop is highly divergent in structure among species and lies immediately upstream of the binding site for Sm proteins.", "output": {"entities": {"gene": [{"text": "Sm proteins", "start": 118, "end": 129}]}}, "schema": []}
{"input": "The deleted nucleotide sequence corresponded to sequences that, by analogy to the organization of the type I collagen genes, should be precisely encoded by exon 41 of the COL3A1 gene.", "output": {"entities": {"gene": [{"text": "type I collagen genes", "start": 102, "end": 123}, {"text": "COL3A1 gene", "start": 171, "end": 182}]}}, "schema": []}
{"input": "These losses account for the resistance of EDS-IV collagen to cyanogen bromide and mammalian collagenase digestion.", "output": {"entities": {"gene": [{"text": "collagen", "start": 50, "end": 58}, {"text": "mammalian collagenase", "start": 83, "end": 104}]}}, "schema": []}
{"input": "Two other peptides, either partially or totally lacking the basic region, but containing the intact leucine zipper domain, readily form dimers but do not bind to the CRE.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast, the CRE of the human c-fos promoter located at-60 was weakly induced by cAMP and E1a in both HeLa and PC12 cells.", "output": {"entities": {"gene": [{"text": "human c-fos promoter", "start": 28, "end": 48}, {"text": "E1a", "start": 94, "end": 97}]}}, "schema": []}
{"input": "We have isolated and sequenced the gene encoding the human U1-70K snRNP protein.", "output": {"entities": {"gene": [{"text": "human U1-70K snRNP protein", "start": 53, "end": 79}]}}, "schema": []}
{"input": "Although popular this hypothesis is far from explaining all the clinical facts, namely that rigidity is equal in extensor and flexor, proximal and distal muscles.", "output": {"entities": {}}, "schema": []}
{"input": "Fluid (AVLF) 31.", "output": {"entities": {}}, "schema": []}
{"input": "The results supported the therapeutic principle of TCM: Treating patients according to their pathophysiological patterns.", "output": {"entities": {}}, "schema": []}
{"input": "The nmr gene is the major negative regulatory gene in the nitrogen control circuit of Neurospora crassa, which, together with positive regulatory genes, governs the expression of multiple unlinked structural genes of the circuit.", "output": {"entities": {"gene": [{"text": "nmr gene", "start": 4, "end": 12}]}}, "schema": []}
{"input": "The 4 days dexamethasone suppression test showed more than 80% suppression of dehydroepiandrosterone-sulphate and a variable (40-60%) reduction of testosterone and androstenedione levels.", "output": {"entities": {}}, "schema": []}
{"input": "The ratio of P-31 NMR-S derived inorganic phosphates [Pi] to phosphocreatine [PCr] was significantly greater at rest in LVH baboons [0. 53 +/-0. 06 versus controls = 0. 41 +/-0. 17; P less than 0. 05].", "output": {"entities": {}}, "schema": []}
{"input": "Cutaneous necrosis associated with protein S deficiency.", "output": {"entities": {"gene": [{"text": "protein S", "start": 35, "end": 44}]}}, "schema": []}
{"input": "Critical study", "output": {"entities": {}}, "schema": []}
{"input": "Regional cerebral blood flow was measured using N-isopropyl-123I-iodoamphetamine with single-photon emission computed tomography (CT) in 16 aged patients with noninsulin-dependent diabetes mellitus (NIDDM, average age 72. 8 years, average fasting plasma glucose 7. 7 mmol/L), and 12 nondiabetic subjects (71. 6 years, 5. 3 mmol/L).", "output": {"entities": {}}, "schema": []}
{"input": "Mean ROI-A/B ratio was 49. 6 +/-1. 7% in the diabetic group, significantly lower than the 57. 9 +/-1. 6% at the nondiabetic group (p less than 0. 005).", "output": {"entities": {}}, "schema": []}
{"input": "These data strongly implicate the normal product of the int-2 gene, which is related to the fibroblast growth factor family, as a contributory factor in virally induced mammary tumors.", "output": {"entities": {"gene": [{"text": "int-2 gene", "start": 56, "end": 66}, {"text": "fibroblast growth factor family", "start": 92, "end": 123}]}}, "schema": []}
{"input": "The PC2 protein also shows great similarity to the incomplete NH2-terminal sequence of the human furin gene product, a putative membrane-inserted receptor-like molecule.", "output": {"entities": {"gene": [{"text": "PC2 protein", "start": 4, "end": 15}, {"text": "human furin gene product", "start": 91, "end": 115}]}}, "schema": []}
{"input": "Whether or not there are sequences conferring cAMP responsiveness which are common both to P-450scc and the other steroidogenic P-450 genes remains to be established.", "output": {"entities": {"gene": [{"text": "P-450scc", "start": 91, "end": 99}, {"text": "P-450 genes", "start": 128, "end": 139}]}}, "schema": []}
{"input": "In this study, we used footprinting and gel mobility retardation assays to reveal that bacterially synthesized Zta fusion proteins bound directly to six TGTGCAA-like motifs within DSL.", "output": {"entities": {"gene": [{"text": "Zta fusion proteins", "start": 111, "end": 130}, {"text": "DSL", "start": 180, "end": 183}]}}, "schema": []}
{"input": "The zta transactivator involved in induction of lytic cycle gene expression in Epstein-Barr virus-infected lymphocytes binds to both AP-1 and ZRE sites in target promoter and enhancer regions.", "output": {"entities": {"gene": [{"text": "zta transactivator", "start": 4, "end": 22}, {"text": "AP-1", "start": 133, "end": 137}, {"text": "ZRE sites", "start": 142, "end": 151}]}}, "schema": []}
{"input": "It is the human homolog of the mouse Mx protein involved in resistance to influenza virus.", "output": {"entities": {"gene": [{"text": "mouse Mx protein", "start": 31, "end": 47}]}}, "schema": []}
{"input": "Fragments containing the 21-base-pair repeat region, the enhancer of simian virus 40 or both strongly stimulated beta-galactosidase synthesis, and three fragments from the polyomavirus enhancer region stimulated moderate levels.", "output": {"entities": {"gene": [{"text": "enhancer of simian virus 40", "start": 57, "end": 84}, {"text": "beta-galactosidase", "start": 113, "end": 131}, {"text": "polyomavirus enhancer region", "start": 172, "end": 200}]}}, "schema": []}
{"input": "The sites targeted for mutagenesis, residues 60, 61, and 66, are located within a putative helical loop structure which may be involved in substrate recognition by the enzyme.", "output": {"entities": {}}, "schema": []}
{"input": "The possible benefits of LMW heparin (reduced frequency of bleeding, alleviation of hypertriglyceridemia) were not, however, apparent, possibly because of the short observation period and the low incidence of hemorrhagic complications in routine dialyses.", "output": {"entities": {}}, "schema": []}
{"input": "The deduced amino acid sequence of destrin is 165 residues long and is very similar (71% identical) to that of cofilin, a widely distributed, pH-sensitive actin-modulating protein.", "output": {"entities": {"gene": [{"text": "destrin", "start": 35, "end": 42}, {"text": "cofilin", "start": 111, "end": 118}, {"text": "actin", "start": 155, "end": 160}]}}, "schema": []}
{"input": "Summers, Virology 89: 517-527, 1978).", "output": {"entities": {}}, "schema": []}
{"input": "With only purified T antigen in the presence of topoisomerase I to unwind purified DNA, ori-auxiliary sequences strongly facilitated T-antigen-dependent DNA conformational changes consistent with melting the first 50 base pairs.", "output": {"entities": {"gene": [{"text": "T antigen", "start": 19, "end": 28}, {"text": "topoisomerase I", "start": 48, "end": 63}, {"text": "T-antigen", "start": 133, "end": 142}]}}, "schema": []}
{"input": "A rabbit antiserum was raised against a synthetic peptide corresponding to a hydrophilic portion of the translated murine cDNA sequence.", "output": {"entities": {}}, "schema": []}
{"input": "Conservation of function of Drosophila melanogaster abl and murine v-abl proteins in transformation of mammalian cells.", "output": {"entities": {"gene": [{"text": "Drosophila melanogaster abl", "start": 28, "end": 55}, {"text": "murine v-abl proteins", "start": 60, "end": 81}]}}, "schema": []}
{"input": "Specific binding of the protein factors to the sites, possibly to the three Mt sequences, may play an important role in the coordinate regulation of the transcription of nuclear genes encoding subunits responsible for mitochondrial oxidative phosphorylation.", "output": {"entities": {}}, "schema": []}
{"input": "This points to a specific interference with HSV-induced DNA amplification.", "output": {"entities": {}}, "schema": []}
{"input": "Constructs were made in which an AATAAA and the GT-rich region were separated by various distances ranging from 7 to 43 bp.", "output": {"entities": {}}, "schema": []}
{"input": "To address this issue, the gene for factor Y has been cloned molecularly and its DNA sequence has been determined.", "output": {"entities": {"gene": [{"text": "factor Y", "start": 36, "end": 44}]}}, "schema": []}
{"input": "We cloned and sequenced the cDNAs against genomic RNA and mRNA for phosphoprotein (P) of human parainfluenza type 2 virus (PIV-2). cDNA clone from genomic RNA was 1439 nucleotides in length excluding poly (A) and was found to have two small open reading frames encoding proteins of 233 and 249 amino acids.", "output": {"entities": {"gene": [{"text": "phosphoprotein (P)", "start": 67, "end": 85}]}}, "schema": []}
{"input": "We show that cytR expression is negatively controlled by the CytR protein and positively affected by the cAMP/CAP complex.", "output": {"entities": {"gene": [{"text": "cytR", "start": 13, "end": 17}, {"text": "CytR protein", "start": 61, "end": 73}, {"text": "cAMP/CAP complex", "start": 105, "end": 121}]}}, "schema": []}
{"input": "The cDNA sequence has an 813-bp open reading frame (ORF) whose predicted amino acid sequence is 97. 6% identical to the 272 carboxy-terminal amino acids of the human ets-1 protein.", "output": {"entities": {"gene": [{"text": "human ets-1 protein", "start": 160, "end": 179}]}}, "schema": []}
{"input": "To characterize the O7-LPS region, the recombinant cosmids pJHCV31 and pJHCV32 were mutagenized by transposon mutagenesis with Tn3HoHo1, which carries a promoterless lac operon and can therefore generate lacZ transcriptional fusions with target DNA sequences.", "output": {"entities": {"gene": [{"text": "O7-LPS region", "start": 20, "end": 33}, {"text": "Tn3HoHo1", "start": 127, "end": 135}, {"text": "lac operon", "start": 166, "end": 176}, {"text": "lacZ", "start": 204, "end": 208}]}}, "schema": []}
{"input": "The sacT gene regulating the sacPA operon in Bacillus subtilis shares strong homology with transcriptional antiterminators.", "output": {"entities": {"gene": [{"text": "sacT gene", "start": 4, "end": 13}, {"text": "sacPA operon in Bacillus subtilis", "start": 29, "end": 62}]}}, "schema": []}
{"input": "Various mutant HN genes were constructed to examine the role of residues flanking the signal-anchor domain, including the cytoplasmic tail, on assembly and intracellular transport of the HN glycoprotein.", "output": {"entities": {"gene": [{"text": "mutant HN genes", "start": 8, "end": 23}, {"text": "HN glycoprotein", "start": 187, "end": 202}]}}, "schema": []}
{"input": "Our studies extend these findings and show that the E2 transactivation gene is expressed from multiple promoters.", "output": {"entities": {"gene": [{"text": "E2 transactivation gene", "start": 52, "end": 75}]}}, "schema": []}
{"input": "Furthermore, analysis of the E2 proteins present in various cell lines harboring specific BPV-1 mutants, including the 2558 acceptor mutant, proves that alternate modes of E2 expression exist.", "output": {"entities": {"gene": [{"text": "E2 proteins", "start": 29, "end": 40}, {"text": "E2", "start": 172, "end": 174}]}}, "schema": []}
{"input": "Disruption of the IRA2 gene resulted in (i) increased sensitivity to heat shock and nitrogen starvation, (ii) sporulation defects, and (iii) suppression of the lethality of the cdc25 mutant.", "output": {"entities": {"gene": [{"text": "IRA2 gene", "start": 18, "end": 27}, {"text": "cdc25 mutant", "start": 177, "end": 189}]}}, "schema": []}
{"input": "This cohort of patients was selected on the basis of clinical stage.", "output": {"entities": {}}, "schema": []}
{"input": "The diagnosis of miliary tuberculosis should be systematically considered in ARDS of unknown origin.", "output": {"entities": {}}, "schema": []}
{"input": "In order to characterize the functional elements of the promoter that in some way must respond to these regulatory signals, a number of promoter mutations were constructed, including a set of linker-scanning mutations across the entire promoter region.", "output": {"entities": {}}, "schema": []}
{"input": "A DNA motif related to the cAMP-responsive element and an exon-located activator protein-2 binding site in the human tissue-type plasminogen activator gene promoter cooperate in basal expression and convey activation by phorbol ester and cAMP.", "output": {"entities": {"gene": [{"text": "exon-located activator protein-2 binding site", "start": 58, "end": 103}, {"text": "human tissue-type plasminogen activator gene promoter", "start": 111, "end": 164}]}}, "schema": []}
{"input": "The 26S rRNA binding ribosomal protein equivalent to bacterial protein L11 is encoded by unspliced duplicated genes in Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "26S rRNA binding ribosomal protein", "start": 4, "end": 38}, {"text": "bacterial protein L11", "start": 53, "end": 74}]}}, "schema": []}
{"input": "Five healthy male subjects inspired air for 20 min and then 5% CO2/95% O2 for 30 min, of which the first 10 min was used to achieve a steady-state end-tidal CO2 measurement.", "output": {"entities": {}}, "schema": []}
{"input": "The transcripts were equally active with or without a 5' methylated capstructure as expected, since EMCV-RNA is one of the mRNAs capable of internal initiation.", "output": {"entities": {}}, "schema": []}
{"input": "The E6/E7 promoter of all genital human papillomaviruses is responsible for expression of the viral transforming genes.", "output": {"entities": {"gene": [{"text": "E6", "start": 4, "end": 6}, {"text": "E7", "start": 7, "end": 9}]}}, "schema": []}
{"input": "A case of Goodpasture' s syndrome.", "output": {"entities": {}}, "schema": []}
{"input": "Seventy-two of 73 negative controls and all positive blocks as seen on soft tissue radiographs (STRs) were correctly coded (specificity 98. 6%, sensitivity 100%).", "output": {"entities": {}}, "schema": []}
{"input": "No symptomatic abnormality has been noted in the neonatal period except periventricular calcifications.", "output": {"entities": {}}, "schema": []}
{"input": "Immunohistochemical analysis of several rat organs also showed staining in epithelial cells.", "output": {"entities": {}}, "schema": []}
{"input": "Transcription of the first operon coding for m-xylene-degrading enzymes on the TOL plasmid of Pseudomonas putida is activated by the xylR gene product in the presence of m-xylene.", "output": {"entities": {"gene": [{"text": "xylR gene product", "start": 133, "end": 150}]}}, "schema": []}
{"input": "Some of the mutations obtained do not contain a copy of the Ulysses element at the mutant locus, suggesting that a different transposable element may be responsible for the mutation.", "output": {"entities": {"gene": [{"text": "Ulysses element", "start": 60, "end": 75}]}}, "schema": []}
{"input": "Determination of diquat in biological materials by electron spin resonance spectroscopy.", "output": {"entities": {}}, "schema": []}
{"input": "We show also that RA represses the transcriptional activity of a reporter gene containing a TPA responding AP1 binding site driving the HSV tk promoter.", "output": {"entities": {"gene": [{"text": "AP1 binding site", "start": 107, "end": 123}, {"text": "HSV tk promoter", "start": 136, "end": 151}]}}, "schema": []}
{"input": "Moreover, radiolabeled EFI, NF-Y, or CBF DNAs give rise to identical gel retardation patterns in extracts from a variety of different cell types.", "output": {"entities": {"gene": [{"text": "EFI", "start": 23, "end": 26}, {"text": "NF-Y", "start": 28, "end": 32}, {"text": "CBF DNAs", "start": 37, "end": 45}]}}, "schema": []}
{"input": "Risk factors influencing lymph nodes metastasis in lung cancer with stage I, II or IIIA", "output": {"entities": {}}, "schema": []}
{"input": "Multifunctional protein kinase (MFPK) phosphorylates ATP-citrate lyase on peptide B on two sites, BT and BS, on threonine and serine, respectively, inhibitor 2 on a threonyl residue, and glycogen synthase at sites 2 and 3.", "output": {"entities": {"gene": [{"text": "Multifunctional protein kinase", "start": 0, "end": 30}, {"text": "MFPK", "start": 32, "end": 36}, {"text": "ATP-citrate lyase", "start": 53, "end": 70}, {"text": "peptide B", "start": 74, "end": 83}, {"text": "inhibitor 2", "start": 148, "end": 159}, {"text": "glycogen synthase", "start": 187, "end": 204}]}}, "schema": []}
{"input": "The electrically induced motile responses were not suppressed in the presence of dinitrophenol or cytochalasin B.", "output": {"entities": {}}, "schema": []}
{"input": "Unlike p59v-rel, which is a nuclear protein in CEF, indirect immunofluorescence showed that p68c-rel in JD214c-rel infected CEF is located exclusively in the cytoplasm of these cells, even though the sequence of p68c-rel showed that it contains a nuclear localizing sequence identical to the one previously identified in p59v-rel.", "output": {"entities": {"gene": [{"text": "p59v", "start": 7, "end": 11}, {"text": "rel", "start": 12, "end": 15}, {"text": "p68c", "start": 92, "end": 96}, {"text": "rel", "start": 97, "end": 100}, {"text": "p68c", "start": 212, "end": 216}, {"text": "rel", "start": 217, "end": 220}, {"text": "p59v", "start": 321, "end": 325}, {"text": "rel", "start": 326, "end": 329}]}}, "schema": []}
{"input": "Kinetic experiments revealed that within 10 min this radiolabeled precursor protein was converted in HL-60 cells into an Mr approximately 150, 000 chondroitin sulfate proteoglycan intermediate.", "output": {"entities": {}}, "schema": []}
{"input": "Blood flow and velocity (measured using Doppler ultrasound) gradually decreased during diastole and ultimately reversed in direction as cotyledon resistance was increased up to 14 fold.", "output": {"entities": {}}, "schema": []}
{"input": "A total of 112 patients received anistreplase and 119 received heparin within a mean period of 188 +/-62 min following the onset of symptoms.", "output": {"entities": {}}, "schema": []}
{"input": "The promoter activity was measured by a transient expression of a chloramphenicol acetyltransferase (CAT) gene connected with various 5'-deletion mutants of the 5'-flanking region.", "output": {"entities": {"gene": [{"text": "chloramphenicol acetyltransferase", "start": 66, "end": 99}, {"text": "CAT", "start": 101, "end": 104}]}}, "schema": []}
{"input": "The Saccharomyces cerevisiae 14DM gene, encoding cytochrome P450 lanosterol 14 alpha-demethylase (14DM), was overexpressed in various S. cerevisiae strains under the control of three strong heterologous yeast transcription promoters (pADC1, pGPD, pPHO5) and under the control of its own promoter.", "output": {"entities": {"gene": [{"text": "Saccharomyces cerevisiae 14DM gene", "start": 4, "end": 38}, {"text": "cytochrome P450 lanosterol 14 alpha-demethylase", "start": 49, "end": 96}, {"text": "14DM", "start": 98, "end": 102}, {"text": "pADC1", "start": 234, "end": 239}, {"text": "pGPD", "start": 241, "end": 245}, {"text": "pPHO5", "start": 247, "end": 252}]}}, "schema": []}
{"input": "Truncations composed of 78 and 64 amino acids were translocated across the endoplasmic reticulum membrane, and translocation was found to be strictly co-translational and SRP-dependent.", "output": {"entities": {"gene": [{"text": "SRP", "start": 171, "end": 174}]}}, "schema": []}
{"input": "Pulmonary vascular resistance was not altered, ejection fraction remained unchanged and isovolumic relaxation period was lengthened (119 +/-20. 1 to 147. 39 +/-21. 15, P less than 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "The ANB1 locus of Saccharomyces cerevisiae encodes the protein synthesis initiation factor eIF-4D.", "output": {"entities": {"gene": [{"text": "ANB1 locus", "start": 4, "end": 14}, {"text": "protein synthesis initiation factor eIF-4D", "start": 55, "end": 97}]}}, "schema": []}
{"input": "Serum beta 2-microglobulin levels (beta-2-M) were studied in 150 drug addicts, 50 of them asymptomatic carriers of anti HIV-1 antibodies, 50 symptomatic carriers with persistent generalized lymphadenopathy (P. G. L.) and 50 serum negative patients who had been living in a closed community for at least 2 years.", "output": {"entities": {"gene": [{"text": "Serum beta 2-microglobulin", "start": 0, "end": 26}, {"text": "beta-2-M", "start": 35, "end": 43}, {"text": "anti HIV-1 antibodies", "start": 115, "end": 136}]}}, "schema": []}
{"input": "This emancipation of the ability to copulate from hormonal influence makes female sexual motivation the primary regulator of mating in primates.", "output": {"entities": {}}, "schema": []}
{"input": "No therapy exists for halting the progression of the disease with the possible exception of laser photocoagulation treatment used to ablate subretinal neovascular membranes in an attempt to avoid complications of subretinal hemorrhages.", "output": {"entities": {}}, "schema": []}
{"input": "R.", "output": {"entities": {}}, "schema": []}
{"input": "Specific hyperimmune globulins to pathogens such as Haemophilus influenzae and Streptococcus pneumoniae have also been studied.", "output": {"entities": {"gene": [{"text": "hyperimmune globulins", "start": 9, "end": 30}]}}, "schema": []}
{"input": "Therapeutic effects of cefpirome (HR 810) on experimental mixed infections with Enterococcus faecalis and Escherichia coli in mice.", "output": {"entities": {}}, "schema": []}
{"input": "Regulation of yeast LEU2.", "output": {"entities": {"gene": [{"text": "yeast LEU2", "start": 14, "end": 24}]}}, "schema": []}
{"input": "Homozygous individuals usually develop purpura fulminans as newborns; heterozygous protein C-deficient individuals are at increased risk for venous thrombosis and pulmonary embolism.", "output": {"entities": {"gene": [{"text": "protein C", "start": 83, "end": 92}]}}, "schema": []}
{"input": "Ischemic stroke due to protein C deficiency.", "output": {"entities": {"gene": [{"text": "protein C", "start": 23, "end": 32}]}}, "schema": []}
{"input": "TREB7 and TREB36 protected all three repeats of the 21 bp, but TREB5 protected only the second repeat.", "output": {"entities": {"gene": [{"text": "TREB7", "start": 0, "end": 5}, {"text": "TREB36", "start": 10, "end": 16}, {"text": "TREB5", "start": 63, "end": 68}]}}, "schema": []}
{"input": "These results suggest that 5 KE X 3/W may be the optimal regimen to augment the antitumor immunity of RNL.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of various deletion mutants indicates that the sequence requirements for binding by QBP in vitro are indistinguishable from those necessary for Q activity in vivo, strongly suggesting that QBP is required for the function of this TATA-independent promoter.", "output": {"entities": {"gene": [{"text": "QBP", "start": 93, "end": 96}, {"text": "QBP", "start": 198, "end": 201}]}}, "schema": []}
{"input": "Since general regulatory factor I (GRFI)/repressor/activator site binding protein 1 (RAP1)/translation upstream factor (TUF) is believed to be an activator of MAT alpha expression, we examined whether PYK1, which is known to be regulated by GRFI/RAP1/TUF, is also affected by the gal11 mutation.", "output": {"entities": {"gene": [{"text": "general regulatory factor I", "start": 6, "end": 33}, {"text": "GRFI", "start": 35, "end": 39}, {"text": "repressor/activator site binding protein 1", "start": 41, "end": 83}, {"text": "RAP1", "start": 85, "end": 89}, {"text": "translation upstream factor", "start": 91, "end": 118}, {"text": "TUF", "start": 120, "end": 123}, {"text": "MAT alpha", "start": 159, "end": 168}, {"text": "PYK1", "start": 201, "end": 205}, {"text": "GRFI", "start": 241, "end": 245}, {"text": "RAP1", "start": 246, "end": 250}, {"text": "TUF", "start": 251, "end": 254}, {"text": "gal11 mutation", "start": 280, "end": 294}]}}, "schema": []}
{"input": "Yeast Gal11 protein mediates the transcriptional activation signal of two different transacting factors, Gal4 and general regulatory factor I/repressor/activator site binding protein 1/translation upstream factor.", "output": {"entities": {"gene": [{"text": "Yeast Gal11 protein", "start": 0, "end": 19}, {"text": "Gal4", "start": 105, "end": 109}, {"text": "general regulatory factor I", "start": 114, "end": 141}, {"text": "repressor/activator site binding protein 1", "start": 142, "end": 184}, {"text": "translation upstream factor", "start": 185, "end": 212}]}}, "schema": []}
{"input": "Deletion from either the N-or C-terminal ends of repA (28 and 69 codons, respectively, out of the 286-codon open reading frame) affected the initiator but not the inhibitory activity.", "output": {"entities": {"gene": [{"text": "repA", "start": 49, "end": 53}]}}, "schema": []}
{"input": "The two larger peptides, one containing amino acids 1-228 and the other containing amino acids 85-228, formed dimers in solution and bound DNA specifically as a dimer.", "output": {"entities": {}}, "schema": []}
{"input": "In vitro transcription extracts from ret1-1 cells terminate less efficiently at weak transcription termination signals than those from RET1 cells, using a variety of tRNA templates.", "output": {"entities": {"gene": [{"text": "ret1-1", "start": 37, "end": 43}, {"text": "RET1", "start": 135, "end": 139}]}}, "schema": []}
{"input": "Guiding patients in the decision should involve a multidisciplinary team composed of a surgical oncologist, geneticist, pathologist, psychotherapist and plastic surgeon.", "output": {"entities": {}}, "schema": []}
{"input": "These factors belong to a set of genetically distinct molecules, including AP-4 and MLTF, that bind to the CACCTGTC motif or related sequences.", "output": {"entities": {"gene": [{"text": "AP-4", "start": 75, "end": 79}, {"text": "MLTF", "start": 84, "end": 88}]}}, "schema": []}
{"input": "Among known flea larvae, the genus Anomiopsyllus (Anomiopsyllinae, Anomiopsyllini) is as distinctive in larval form as are the adults.", "output": {"entities": {}}, "schema": []}
{"input": "Here, we have used specific antibody to identify and characterize the SSN6 protein.", "output": {"entities": {"gene": [{"text": "SSN6 protein", "start": 70, "end": 82}]}}, "schema": []}
{"input": "These latter results showed that the ABFI protein, like the RAP1 protein, bound sequences required for positive as well as negative regulation of gene expression.", "output": {"entities": {"gene": [{"text": "ABFI protein", "start": 37, "end": 49}, {"text": "RAP1 protein", "start": 60, "end": 72}]}}, "schema": []}
{"input": "Clinical nutrition of adult horses.", "output": {"entities": {}}, "schema": []}
{"input": "The computer-programmed cytocentrifuge is currently most popular.", "output": {"entities": {}}, "schema": []}
{"input": "RNase protection assays reveal that this gene, unr, is transcribed in the same direction as N-ras and that its 3' end is located just 130 base pairs away from the point at which N-ras transcription begins.", "output": {"entities": {"gene": [{"text": "RNase", "start": 0, "end": 5}, {"text": "unr", "start": 47, "end": 50}, {"text": "N-ras", "start": 92, "end": 97}, {"text": "N-ras", "start": 178, "end": 183}]}}, "schema": []}
{"input": "Isolation of a temperature-sensitive mutant with an altered tRNA nucleotidyltransferase and cloning of the gene encoding tRNA nucleotidyltransferase in the yeast Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "tRNA nucleotidyltransferase", "start": 60, "end": 87}, {"text": "gene encoding tRNA nucleotidyltransferase in the yeast Saccharomyces cerevisiae", "start": 107, "end": 186}]}}, "schema": []}
{"input": "The juxtamembrane region of the insulin receptor (IR) beta-subunit contains an unphosphorylated tyrosyl residue (Tyr960) that is essential for insulin-stimulated tyrosyl phosphorylation of some endogenous substrates and certain biological responses (White, M. F., Livingston, J. N., Backer, J. M., Lauris, V., Dull, T. J., Ullrich, A., and Kahn, C. R.", "output": {"entities": {"gene": [{"text": "insulin receptor (IR) beta-subunit", "start": 32, "end": 66}, {"text": "insulin", "start": 143, "end": 150}]}}, "schema": []}
{"input": "This gene joins the group of genes whose members are rapidly transcribed in response to insulin and other mitogens.", "output": {"entities": {"gene": [{"text": "insulin", "start": 88, "end": 95}]}}, "schema": []}
{"input": "The 3' region, GA2, is necessary for maximal expression.", "output": {"entities": {"gene": [{"text": "GA2", "start": 15, "end": 18}]}}, "schema": []}
{"input": "Pups placed into the novel environment with their mothers exhibited an intermediate level of DA turnover.", "output": {"entities": {}}, "schema": []}
{"input": "The efficacy and safety of a novel percutaneous anaesthetic preparation based on amethocaine has been investigated in the paediatric clinical environment.", "output": {"entities": {}}, "schema": []}
{"input": "Homozygous protein C (PC) deficiency is reported in two siblings (girl and boy) who received their proper diagnoses at the ages of 7 4/12 and 1 3/12 years respectively.", "output": {"entities": {"gene": [{"text": "protein C", "start": 11, "end": 20}, {"text": "PC", "start": 22, "end": 24}]}}, "schema": []}
{"input": "The grandfather and the granddaughter both had microtia and meatal atresia, whereas the daughter had a normal outer ear except for a narrow meatus and auricular appendages.", "output": {"entities": {}}, "schema": []}
{"input": "Abnormal intrapulmonary shunting (IPS), which was proved in 4 cases by whole-body radionuclide scanning with 99mTc-MAA, is suggested as the major cause of cyanosis in liver cirrhosis.", "output": {"entities": {}}, "schema": []}
{"input": "More generally, Ets1 and Ets2 could regulate transcription of cellular genes.", "output": {"entities": {"gene": [{"text": "Ets1", "start": 16, "end": 20}, {"text": "Ets2", "start": 25, "end": 29}]}}, "schema": []}
{"input": "Within this sequence the MSAS gene was identified as a 5322-bp-long open reading frame coding for a protein of 1774 amino acids and 190, 731 Da molecular mass.", "output": {"entities": {"gene": [{"text": "MSAS gene", "start": 25, "end": 34}]}}, "schema": []}
{"input": "Horseradish peroxidase as a permeability marker in injured rat caudal and iliac arteries.", "output": {"entities": {"gene": [{"text": "Horseradish peroxidase", "start": 0, "end": 22}]}}, "schema": []}
{"input": "Standardized gastric wall specimens from the area of grossly healed ulcers were obtained, processed, and evaluated by light microscopy and by transmission electron microscopy.", "output": {"entities": {}}, "schema": []}
{"input": "2.", "output": {"entities": {}}, "schema": []}
{"input": "The effects of coenzyme Q10 (CoQ) and captopril on functional capacity, hemodynamics and survival were studied in 154 rats that recovered after experimental myocardial infarction.", "output": {"entities": {}}, "schema": []}
{"input": "Evidence that therapeutic alterations of a circadian rhythm for gastric emptying response may be possible.", "output": {"entities": {}}, "schema": []}
{"input": "The interrelation of the levels of glucocorticoids and insulin in the blood of irradiated animals", "output": {"entities": {"gene": [{"text": "insulin", "start": 55, "end": 62}]}}, "schema": []}
{"input": "This last includes tissue O2 transfer (Ft') and mitochondrial O2 utilization (Fm').", "output": {"entities": {}}, "schema": []}
{"input": "Foveating saccades, therefore, can be distinguished from other FEMs on the basis of speed.", "output": {"entities": {}}, "schema": []}
{"input": "Incidence correlated with the grade of oral hygiene und periodontal disease.", "output": {"entities": {}}, "schema": []}
{"input": "Our study shows that the area of Alcoy is a medium MS risk region according to the thesis of Kurzke, although high MS areas may be found, thus confirming that MS distribution in southern Europe is not uniform.", "output": {"entities": {}}, "schema": []}
{"input": "On an antithrombin unit basis, CY 216 and CY 222 were equivalent and more potent than UH.", "output": {"entities": {"gene": [{"text": "antithrombin", "start": 6, "end": 18}]}}, "schema": []}
{"input": "Chick brain actin depolymerizing factor (ADF) is a 19-kDa protein that severs actin filaments and binds actin monomers.", "output": {"entities": {"gene": [{"text": "Chick brain actin depolymerizing factor", "start": 0, "end": 39}, {"text": "ADF", "start": 41, "end": 44}, {"text": "actin filaments", "start": 78, "end": 93}, {"text": "actin monomers", "start": 104, "end": 118}]}}, "schema": []}
{"input": "Initial experience with a serotonin agonist.", "output": {"entities": {}}, "schema": []}
{"input": "Comprehensive care of the patient exposed to a human teratogen may also include discussion of prenatal diagnostic procedures and other pregnancy management options.", "output": {"entities": {}}, "schema": []}
{"input": "Primer extension analysis and RNA sequencing demonstrates that the transcription start point of rat ODC mRNA is located 303 nt upstream from the A residue in the start codon.", "output": {"entities": {"gene": [{"text": "rat ODC mRNA", "start": 96, "end": 108}]}}, "schema": []}
{"input": "For 85Sr, larger-than-expected distribution coefficients were obtained in the desorption experiments, an indication of the irreversible formation of metal-oxyhydroxides during a slow reaction.", "output": {"entities": {}}, "schema": []}
{"input": "Gene constructs possessing the complete tat, rev (tat + rev +) and env genes were transiently expressed in COS-1 cells as precursor SU-TM (gp160), SU. TM (gp120 x 41), and nucleolar rev protein.", "output": {"entities": {"gene": [{"text": "complete tat", "start": 31, "end": 43}, {"text": "rev", "start": 45, "end": 48}, {"text": "tat + rev +", "start": 50, "end": 61}, {"text": "env genes", "start": 67, "end": 76}, {"text": "precursor SU-TM", "start": 122, "end": 137}, {"text": "gp160", "start": 139, "end": 144}, {"text": "SU. TM", "start": 147, "end": 153}, {"text": "gp120 x 41", "start": 155, "end": 165}, {"text": "nucleolar rev protein", "start": 172, "end": 193}]}}, "schema": []}
{"input": "This growth arrest is partly suppressed on minimal medium or under conditions in which the cells are less dependent on mitochondrial metabolism.", "output": {"entities": {}}, "schema": []}
{"input": "Giant pilomatrix carcinoma: report and review of the literature.", "output": {"entities": {}}, "schema": []}
{"input": "Further studies of mandibular movement at initial tooth contact.", "output": {"entities": {}}, "schema": []}
{"input": "Each parent interacted with their 4-or 5-year-old son or daughter in each of two conversations--unstructured (social conversation) and structured (task activity).", "output": {"entities": {}}, "schema": []}
{"input": "Droperidol-induced extrapyramidal symptoms in an adolescent following strabismus surgery.", "output": {"entities": {}}, "schema": []}
{"input": "These results indicate that the cis-regulatory elements required for developmental control of the HaG3-A helianthinin gene are located in a 2. 4 kb upstream region of this gene.", "output": {"entities": {"gene": [{"text": "HaG3-A helianthinin gene", "start": 98, "end": 122}]}}, "schema": []}
{"input": "The induction by pseudorabies virus of an IL-6 construct containing the IL-6 TATA box and the RNA start site (\" initiator \" or Inr element) but not the MRE region was also repressed by Dex in the presence of wild-type GR.", "output": {"entities": {"gene": [{"text": "IL-6 construct", "start": 42, "end": 56}, {"text": "IL-6 TATA box", "start": 72, "end": 85}, {"text": "wild-type GR", "start": 208, "end": 220}]}}, "schema": []}
{"input": "Some mutations affected Dhfr in a qualitative manner, such as by changing the startpoint of one of the major Dhfr transcripts or changing the relative abundance of the two major Dhfr transcripts.", "output": {"entities": {"gene": [{"text": "Dhfr", "start": 24, "end": 28}, {"text": "Dhfr transcripts", "start": 109, "end": 125}, {"text": "Dhfr transcripts", "start": 178, "end": 194}]}}, "schema": []}
{"input": "The glial cyst wall was lined in part by flattened or cuboidal epithelium.", "output": {"entities": {}}, "schema": []}
{"input": "We conclude that class I cytologic smears with moderate to severe inflammation may be associated with findings of condylomata and cervical dysplasia.", "output": {"entities": {}}, "schema": []}
{"input": "As in mammals, considerable nucleotide diversity was observed at the junctions of the variable, diversity, and joining elements in chicken TCR beta cDNAs.", "output": {"entities": {"gene": [{"text": "chicken TCR beta cDNAs", "start": 131, "end": 153}]}}, "schema": []}
{"input": "The protooncogene c-myb encodes a nuclear transcription factor that binds to DNA in a sequence-specific manner and transactivates transcription of several viral and cellular genes.", "output": {"entities": {"gene": [{"text": "c-myb", "start": 18, "end": 23}]}}, "schema": []}
{"input": "Modification by this latter compound was so extensive that the amount of membrane-associated N-myristoylated protein was decreased.", "output": {"entities": {}}, "schema": []}
{"input": "S6 kinase activation requires displacement of this inhibitory segment, which is proposed to occur consequent to its multiple phosphorylation.", "output": {"entities": {"gene": [{"text": "S6 kinase", "start": 0, "end": 9}]}}, "schema": []}
{"input": "Cerebral flow and resistance showed minor reductions with HD.", "output": {"entities": {}}, "schema": []}
{"input": "Utilization of alternative polyadenylation signals was previously shown to generate two sialophorin mRNAs of 1. 9 and 4. 3 kb, which differ in the length of their 3' untranslated regions.", "output": {"entities": {"gene": [{"text": "sialophorin mRNAs of 1. 9 and 4. 3 kb", "start": 88, "end": 125}]}}, "schema": []}
{"input": "Presidential address 1990--coming in from the cold.", "output": {"entities": {}}, "schema": []}
{"input": "The Jenkins Activity Survey and the CPI-revised: further evidence of adaptive and maladaptive type A traits.", "output": {"entities": {}}, "schema": []}
{"input": "There was evidence of attenuated regression slopes relating recalled to observed portion sizes for 4 of the 10 food groups; adjusted r2 values for the recalled portion sizes ranged from 0. 02 to 0. 94.", "output": {"entities": {}}, "schema": []}
{"input": "The result suggests that this non-invasive TTD method is easily available and useful in monitoring the intraoperative cardiac output.", "output": {"entities": {}}, "schema": []}
{"input": "The TUP1 gene was isolated in a screen for genes that regulate mating type (V. L.", "output": {"entities": {"gene": [{"text": "TUP1 gene", "start": 4, "end": 13}]}}, "schema": []}
{"input": "The SUP44 suppressor mutation occurs near a region of the protein that corresponds to the known positions of alterations in E. coli S5 ram mutations.", "output": {"entities": {"gene": [{"text": "SUP44 suppressor mutation", "start": 4, "end": 29}, {"text": "E. coli S5 ram mutations", "start": 124, "end": 148}]}}, "schema": []}
{"input": "Interestingly, disruption of the VPS34 locus resulted in a temperature-sensitive growth defect, indicating that the VPS34 gene is essential for vegetative growth only at elevated growth temperatures.", "output": {"entities": {"gene": [{"text": "VPS34 locus", "start": 33, "end": 44}, {"text": "VPS34 gene", "start": 116, "end": 126}]}}, "schema": []}
{"input": "We describe a case of a perinephric abscess treated with amphotericin B and nephrectomy.", "output": {"entities": {}}, "schema": []}
{"input": "This interaction occurs over a wide range of both parameters; for charge density from at least 10 to 800 microC/cm2 and, for charge per phase, from at least 0. 05 to 5. 0 microC per phase.", "output": {"entities": {}}, "schema": []}
{"input": "Perceptions of illness intrusiveness were significantly higher when both muscle cramp and headache symptoms occurred during one or more assessment intervals as compared to when muscle cramps or headaches, only, occurred.", "output": {"entities": {}}, "schema": []}
{"input": "Results have surprisingly revealed the presence of three U14 snRNA-homologous regions positioned within introns 5, 6, and 8 of the mouse cognate hsc70 heat shock gene.", "output": {"entities": {"gene": [{"text": "U14 snRNA-homologous regions", "start": 57, "end": 85}, {"text": "hsc70", "start": 145, "end": 150}]}}, "schema": []}
{"input": "65-kilodalton protein phosphorylated by interleukin 2 stimulation bears two putative actin-binding sites and two calcium-binding sites.", "output": {"entities": {"gene": [{"text": "interleukin 2", "start": 40, "end": 53}, {"text": "actin-binding sites", "start": 85, "end": 104}]}}, "schema": []}
{"input": "The highly restrained girls had a significantly higher EAT score than the low-restrained girls, and shared with their mothers a susceptibility to the disinhibitory effects of negative mood states on their eating behaviour.", "output": {"entities": {}}, "schema": []}
{"input": "Sequence and genetic organization of a Zymomonas mobilis gene cluster that encodes several enzymes of glucose metabolism.", "output": {"entities": {}}, "schema": []}
{"input": "For this, cDNAs containing the 60K, 87K, 110K and 170K protein coding sequences were each provided with an ATG start codon and the cDNA containing the 60K coding sequence with a TAA stop codon immediately downstream of the coding sequence.", "output": {"entities": {}}, "schema": []}
{"input": "Finally, a complementary footprinting analysis of the upstream region of the constitutively expressed HSC82 gene reveals the presence of three discrete protein complexes.", "output": {"entities": {"gene": [{"text": "HSC82 gene", "start": 102, "end": 112}]}}, "schema": []}
{"input": "Pathophysiology of bone loss in castrated animals.", "output": {"entities": {}}, "schema": []}
{"input": "Auditory-visual interaction in the generation of saccades in man.", "output": {"entities": {}}, "schema": []}
{"input": "First, each lung was cut into slices, from which primary disectors were sampled systematically with a known sampling fraction.", "output": {"entities": {}}, "schema": []}
{"input": "The upstream promoter is located within the coding sequence of a divergent gene expressing a protein of Mr 39 kDa of unknown function.", "output": {"entities": {}}, "schema": []}
{"input": "Assuming O2 consumption of the isolated skin to be same as in situ, calculations showed that when water PO2 was high (150 mm Hg), about 40% of total cutaneous O2 uptake was consumed by the skin.", "output": {"entities": {}}, "schema": []}
{"input": "MCh infusion caused a concentration-dependent increase in airway resistance at constant QBA.", "output": {"entities": {}}, "schema": []}
{"input": "Plasma concentrations of atracurium and laudanosine were 0. 73-3. 11 micrograms ml-1 and 0. 48-8. 65 micrograms ml-1, respectively; CSF concentration of laudanosine was 70-440 ng ml-1.", "output": {"entities": {}}, "schema": []}
{"input": "Plasma Al was obtained during each baseline and drug course.", "output": {"entities": {}}, "schema": []}
{"input": "The survival in the case of these patients was studied five years later.", "output": {"entities": {}}, "schema": []}
{"input": "The occurrence, maintenance and possible involvement of these repeated sequences, capable of forming stable secondary structures, are discussed in relation to their location in the region of control signals.", "output": {"entities": {}}, "schema": []}
{"input": "IST is not the RNA target (TAR) for Tat trans-activation; however, because it relies entirely on cellular factors for activity, IST may serve to provide abundant RNA targets for Tat trans-activation without a requirement for full-length viral mRNA expression.", "output": {"entities": {"gene": [{"text": "IST", "start": 0, "end": 3}, {"text": "Tat", "start": 36, "end": 39}, {"text": "IST", "start": 128, "end": 131}, {"text": "Tat", "start": 178, "end": 181}]}}, "schema": []}
{"input": "Genotoxic activity of a tobacco-specific nitrosamine.", "output": {"entities": {}}, "schema": []}
{"input": "The endodontal treatment need has been forming a clinical order of magnitude.", "output": {"entities": {}}, "schema": []}
{"input": "These results may suggest involvement of peripheral enkephalins in pain modulation in patients with episodic cluster headache.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of cisapride on upper-gastrointestinal motility and digestive hormones", "output": {"entities": {}}, "schema": []}
{"input": "Common foot pathologies are heel pain, metatarsalgia, hammertoes and clawtoes, bunions, hallux rigidus, corns and calluses, nail pathologies, arthritis, and neuropathies.", "output": {"entities": {}}, "schema": []}
{"input": "Liver dysfunction in the presence of different adverse reactions presented with a higher activity in the blood serum of indicator liver enzymes and its impaired protein-forming function.", "output": {"entities": {}}, "schema": []}
{"input": "Coenzyme Q10: blood levels and metabolic demand.", "output": {"entities": {}}, "schema": []}
{"input": "The CT characteristics are discussed and the recent literature is reviewed.", "output": {"entities": {}}, "schema": []}
{"input": "Unfortunately, these preservatives may also interfere with microbiological assays used to determine product sterility or bioburden levels.", "output": {"entities": {}}, "schema": []}
{"input": "In 26 patients with angina pectoris, the changes of LVEF, LVESV and PSP/LVESV were more sensitive for the detection of exercise-induced ischemia than the appearance of chest pain and the changes of ECG.", "output": {"entities": {}}, "schema": []}
{"input": "In both groups there were 5 management failure of therapy, so that alternative medication or a cesarean section lead to delivery.", "output": {"entities": {}}, "schema": []}
{"input": "Serum Fibrin Degradation Products (FDP) were determined in 50 oral cancer patients and 50 normal individuals prior to any kind of treatment.", "output": {"entities": {"gene": [{"text": "Fibrin Degradation Products", "start": 6, "end": 33}, {"text": "FDP", "start": 35, "end": 38}]}}, "schema": []}
{"input": "The uteroglobin promoter contains a noncanonical estrogen responsive element.", "output": {"entities": {"gene": [{"text": "uteroglobin promoter", "start": 4, "end": 24}]}}, "schema": []}
{"input": "Prostaglandin synthesis inhibitors have been shown to delay healing of bone and this has led to limitations on their use clinically in some situations.", "output": {"entities": {}}, "schema": []}
{"input": "The inspiratory oxygen concentration needed (FiO2) and the Horowitz quotient differed in a highly significant manner beginning on the 1st day after trauma.", "output": {"entities": {}}, "schema": []}
{"input": "The corn and mineral oil emulsions were almost as effective as milk but less effective than sucrose (0. 3M) in stimulating ingestion.", "output": {"entities": {}}, "schema": []}
{"input": "Significance of thin glomerular basement membranes in hematuric children.", "output": {"entities": {}}, "schema": []}
{"input": "Significance of cytokine production and adhesion molecules in malarial immunopathology.", "output": {"entities": {}}, "schema": []}
{"input": "The former procedure is economical but complicated, whereas the latter is simple and labour-saving, but a special ultrafiltration tube is required.", "output": {"entities": {}}, "schema": []}
{"input": "Simple method for determination of the cephalosporin DQ-2556 in biological fluids by high-performance liquid chromatography.", "output": {"entities": {}}, "schema": []}
{"input": "Since one group of adolescents more difficult to influence are those whose parents smoke, parental involvement in smoking prevention may be a powerful enhancer.", "output": {"entities": {}}, "schema": []}
{"input": "Further research is recommended to identify the coping styles associated with the high EE/low EE research classification.", "output": {"entities": {}}, "schema": []}
{"input": "Staining with IF MoAB alone of BAL fluid only seemed to be even more sensitive than silver methenamine staining of BAL, TBB and brushing material.", "output": {"entities": {}}, "schema": []}
{"input": "Ultrastructural and morphometric study of the myeloid parenchyma cells of mice prior and after X-ray exposure", "output": {"entities": {}}, "schema": []}
{"input": "Using an audiotape cassette and headphones the duration of the hallucinations decreased significantly.", "output": {"entities": {}}, "schema": []}
{"input": "The mean change in HbA1, adjusted for the initial value, was-0. 4% in the experimental and + 0. 5% in the control group (p less than 0. 05).", "output": {"entities": {"gene": [{"text": "HbA1", "start": 19, "end": 23}]}}, "schema": []}
{"input": "Effect of biliary obstruction and cholangitis on serum SPan-1 level", "output": {"entities": {"gene": [{"text": "serum SPan-1", "start": 49, "end": 61}]}}, "schema": []}
{"input": "Very good accuracy (r greater than 0. 9) was found when except comparing H * 2 with the other machine and the reference methods, except for MCHCH and basophil count.", "output": {"entities": {}}, "schema": []}
{"input": "The second part of this paper shows some medical applications of these two aspects of NMR, with help of some examples, taken from the literature, according to what is concerned with endocrinology.", "output": {"entities": {}}, "schema": []}
{"input": "Interlimb coordination during fictive locomotion in the thalamic cat.", "output": {"entities": {}}, "schema": []}
{"input": "Antileukoproteinase (ALP) is a low mol wt mucosal secretory protein which, in human tissues, inhibits the activities of the neutral serine lysosomal proteinases elastase and cathepsin-G.", "output": {"entities": {"gene": [{"text": "Antileukoproteinase", "start": 0, "end": 19}, {"text": "ALP", "start": 21, "end": 24}, {"text": "serine lysosomal proteinases elastase", "start": 132, "end": 169}, {"text": "cathepsin-G", "start": 174, "end": 185}]}}, "schema": []}
{"input": "By introducing a series of deletions in the vimentin promoter, we further restrict these sequences to 30 base pairs, located between 241 and 210 base pairs upstream of the mRNA cap site.", "output": {"entities": {"gene": [{"text": "vimentin", "start": 44, "end": 52}]}}, "schema": []}
{"input": "In particular, 71 and 69% amino acid sequence similarities were identified with hsp70 of Escherichia coli and Bacillus megaterium, respectively.", "output": {"entities": {"gene": [{"text": "hsp70 of Escherichia coli and Bacillus megaterium", "start": 80, "end": 129}]}}, "schema": []}
{"input": "All 89 participating household members were anti-HIV seronegative, and 78 who were tested were serum p24 antigen negative.", "output": {"entities": {"gene": [{"text": "anti-HIV", "start": 44, "end": 52}, {"text": "serum p24 antigen", "start": 95, "end": 112}]}}, "schema": []}
{"input": "To those of us who are not satisfied with the present outlook there is much to be investigated and much to be contributed.", "output": {"entities": {}}, "schema": []}
{"input": "To determine the effects on the pulmonary barrier of several surface active agents, a series of metered dose inhalers (MDIs) was prepared and used to dose aerosolized surfactant to the airways of isolated perfused rat lungs.", "output": {"entities": {}}, "schema": []}
{"input": "The beta chain contains five potential N-linked glycosylation sites, and endoglycosidase digestion suggested that the beta chain contained multiple complex carbohydrate side chains.", "output": {"entities": {"gene": [{"text": "endoglycosidase", "start": 73, "end": 88}]}}, "schema": []}
{"input": "The therapeutic protocole used at the Gustave Roussy Institute for invasive epithelioma of the uterine cervix rests, for limited forms (T1B-T2 proximal), on combined radiology and surgery.", "output": {"entities": {}}, "schema": []}
{"input": "Thyrotropin-induced expression of a gene for a ribosomal protein related to the trk oncogene.", "output": {"entities": {"gene": [{"text": "Thyrotropin", "start": 0, "end": 11}, {"text": "ribosomal protein", "start": 47, "end": 64}, {"text": "trk oncogene", "start": 80, "end": 92}]}}, "schema": []}
{"input": "The introns are 1. 6-1. 9 kbp long.", "output": {"entities": {}}, "schema": []}
{"input": "After an initial titration period and adjustment of the therapeutic dose, the individual doses were from 21 to 500 micrograms/24 hrs (mean 160 micrograms/24 hrs).", "output": {"entities": {}}, "schema": []}
{"input": "In the first series of experiments, Sprague-Dawley male rats were implanted unilaterally with guide cannulas aimed at the lateral ventricle.", "output": {"entities": {}}, "schema": []}
{"input": "Use of Selenastrum capricornutum and Microfeast as food for Daphnia pulex.", "output": {"entities": {}}, "schema": []}
{"input": "The persistence of members of the prostigmatid families Tydeidae, Nanorchestidae and Tarsonemidae in the moisture-deficient 90%-concentration treatments supports previous evidence of adaptations to low-water-content habitats.", "output": {"entities": {}}, "schema": []}
{"input": "To define the mechanism responsible for the loss of transcription elongation blockage and resulting c-myc deregulation in Burkitt' s lymphoma, we analyzed transcription patterns after transfer of normal and Burkitt' s lymphoma c-myc alleles into murine cells and Xenopus oocyte germinal vesicles.", "output": {"entities": {"gene": [{"text": "c-myc", "start": 100, "end": 105}, {"text": "c-myc", "start": 227, "end": 232}]}}, "schema": []}
{"input": "From an RNK-16 lambda-gt11 library, we have isolated and sequenced a novel cDNA rat NK cell protease 1 (RNKP-1) that has characteristics unique to serine proteases.", "output": {"entities": {"gene": [{"text": "rat NK cell protease 1", "start": 80, "end": 102}, {"text": "RNKP-1", "start": 104, "end": 110}, {"text": "serine proteases", "start": 147, "end": 163}]}}, "schema": []}
{"input": "The induction of RNKP-1 expression in the Con A-cultured spleen cells is accompanied by increases in both NK and lymphokine-activated killer lymphocyte activities.", "output": {"entities": {"gene": [{"text": "RNKP-1", "start": 17, "end": 23}, {"text": "Con A", "start": 42, "end": 47}]}}, "schema": []}
{"input": "The paper is concerned with the data on change in the blood level of ACTH, STH, TSH, cortisol, T3, insulin, C-peptide during a 25-minute session of respiration using a gaseous hypoxic mixture with 10% oxygen (GHM-10).", "output": {"entities": {"gene": [{"text": "ACTH", "start": 69, "end": 73}, {"text": "STH", "start": 75, "end": 78}, {"text": "TSH", "start": 80, "end": 83}, {"text": "insulin", "start": 99, "end": 106}, {"text": "C-peptide", "start": 108, "end": 117}]}}, "schema": []}
{"input": "The abscess was debrided and the septum was patched with a single layer of autologous pericardium.", "output": {"entities": {}}, "schema": []}
{"input": "In 18% lymphography was clearly positive and CT negative.", "output": {"entities": {}}, "schema": []}
{"input": "The present study examined the effect of intensity, rate, and polarity on the spectral content of ABRs of 15 normal-hearing subjects.", "output": {"entities": {}}, "schema": []}
{"input": "Similar memory impairments found in medial septal-vertical diagonal band of Broca and nucleus basalis lesioned rats: are memory defects induced by nucleus basalis lesions related to the degree of non-specific subcortical cell loss? The function of nucleus basalis (NB) and medial septal-vertical diagonal band of Broca (MS-VDBB) in a place navigation task requiring reference memory was investigated.", "output": {"entities": {}}, "schema": []}
{"input": "Studies also have alluded to a relationship between the MSMR cyst and certain signs or symptoms of disease.", "output": {"entities": {}}, "schema": []}
{"input": "The BAL-to-plasma specific activity of urea was about twice that of Na +, indicating that urea diffused into the ELF more rapidly than Na + during the 70 s that elapsed between the time the radioactive urea and Na + were injected into the circulation and the time when lavage was complete.", "output": {"entities": {}}, "schema": []}
{"input": "The kappa coefficient of agreement between the Patho Dx Kit and the standard method was 0. 958.", "output": {"entities": {}}, "schema": []}
{"input": "Senior systems--45; Mental health and illness in old age--3.", "output": {"entities": {}}, "schema": []}
{"input": "When normalized for imaging time, all parameters are significantly higher with RASE, with a C/A per unit time that was 338% higher.", "output": {"entities": {}}, "schema": []}
{"input": "Patients with acute myocardial infarction had higher plasma concentrations of neutrophil elastase and the non-peroxide diene conjugated isomer of linoleic acid than normal volunteers or patients with stable ischaemic heart disease.", "output": {"entities": {"gene": [{"text": "neutrophil elastase", "start": 78, "end": 97}]}}, "schema": []}
{"input": "The cis-acting element, identified as CACGTGACCCG, is located 34 bp upstream from the transcription initiation site, and contains the core sequence of the upstream promoter sequence of Ad2MLP.", "output": {"entities": {"gene": [{"text": "Ad2MLP", "start": 185, "end": 191}]}}, "schema": []}
{"input": "The clinical relevance of these findings is strengthened by the observation that similar results were obtained when P. HCl was given by the intravenous route.", "output": {"entities": {}}, "schema": []}
{"input": "TMBr-1 is identical to striated muscle alpha-tropomyosin from amino acids 1 through 258 but contains a novel COOH-terminal region from amino acids 259 through 281.", "output": {"entities": {"gene": [{"text": "TMBr-1", "start": 0, "end": 6}, {"text": "striated muscle alpha-tropomyosin", "start": 23, "end": 56}]}}, "schema": []}
{"input": "The procedure has been applied to three materials: particle board with carpet; gypsum board with wallpaper; and plywood with polyurethane lacquer, for which the steady-state emission factors (mg m-2 h-1) of several compounds are given.", "output": {"entities": {}}, "schema": []}
{"input": "Intron 1 is 6. 5 kb long, and the minimal sizes of introns 2 and 3 are estimated to be 32 kb each.", "output": {"entities": {}}, "schema": []}
{"input": "After 4 h, lesions in the secretory part of the stomach were scored and mucosal prostaglandin E2 synthesis was determined by the ex vivo prostaglandin generation technique.", "output": {"entities": {}}, "schema": []}
{"input": "Comparison of transmembrane and cytoplasmic domains to a third cell-surface proteoglycan, 48K5 from human lung fibroblasts (Marynen, P., Zhang, J., Cassiman, J., Vanden Berghe, H., and David, C.", "output": {"entities": {"gene": [{"text": "48K5", "start": 90, "end": 94}]}}, "schema": []}
{"input": "Approximately 65% of the total cAMP-dependent phosphotransferase activity is recovered in particulate fractions of homogenates prepared from asynchronous populations of C. elegans.", "output": {"entities": {"gene": [{"text": "cAMP-dependent phosphotransferase", "start": 31, "end": 64}]}}, "schema": []}
{"input": "High levels of C subunits are observed in several subsequent larval and adult stages of development.", "output": {"entities": {"gene": [{"text": "C subunits", "start": 15, "end": 25}]}}, "schema": []}
{"input": "A second, novel C subunit (CeCAT alpha', 374 residues) has a unique 56-residue carboxyl-terminal region that is generated by the alternative splicing of the C pre-mRNA.", "output": {"entities": {"gene": [{"text": "CeCAT alpha'", "start": 27, "end": 39}, {"text": "C pre-mRNA", "start": 157, "end": 167}]}}, "schema": []}
{"input": "The alternative exon introduces the novel carboxyl terminus and a new translation stop signal, while simultaneously converting the coding sequence for 40 carboxyl-terminal residues in CeCAT alpha into 3'-untranslated nucleotides.", "output": {"entities": {"gene": [{"text": "CeCAT alpha", "start": 184, "end": 195}]}}, "schema": []}
{"input": "French, M.", "output": {"entities": {}}, "schema": []}
{"input": "Slowly adapting type I mechanoreceptor discharge as a function of dynamic force versus dynamic displacement of glabrous skin of raccoon and squirrel monkey hand.", "output": {"entities": {}}, "schema": []}
{"input": "Plasma lecithin/cholesterol acyltransferase (LCAT) activity in multiple-organ donors: a predictor of allograft viability in clinical liver transplantation.", "output": {"entities": {"gene": [{"text": "lecithin/cholesterol acyltransferase", "start": 7, "end": 43}, {"text": "LCAT", "start": 45, "end": 49}]}}, "schema": []}
{"input": "Axillary nodal status, tumour progesterone receptor status, and season of tumour detection significantly influenced survival in both older (greater than 50 yrs) and younger (less than 50 yrs) patients.", "output": {"entities": {"gene": [{"text": "progesterone receptor", "start": 30, "end": 51}]}}, "schema": []}
{"input": "The application of these microelectrodes to the measurement of rapid, transient changes in retinal [K +] o is presented.", "output": {"entities": {}}, "schema": []}
{"input": "Expression, cellular localization and in vitro transcription studies establish that cloned hUBF encodes a nucleolar factor that binds specifically to the upstream control element and core of the rRNA gene promoter to activate transcription in a binding site-dependent manner.", "output": {"entities": {"gene": [{"text": "cloned hUBF", "start": 84, "end": 95}]}}, "schema": []}
{"input": "Combining multiple laboratory studies may be of value in predetermining the eventual outcome in near-drowning.", "output": {"entities": {}}, "schema": []}
{"input": "There was a gradual increase in the myocyte diameter according to age in the biopsy and autopsy specimens.", "output": {"entities": {}}, "schema": []}
{"input": "Despite the absence of exercise-induced asthma (EIA) while breathing WH air, asthmatic patients still had significantly higher mean GH increments than normal subjects (9. 2 vs 2. 3 ng/ml, P less than 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "The afferents' phase of response was unmodified by electrical EVS stimulation.", "output": {"entities": {}}, "schema": []}
{"input": "Solving an age old problem.", "output": {"entities": {}}, "schema": []}
{"input": "The distribution of their fibrinogen levels was Gaussian, but more wide-based than the distribution of our normal controls.", "output": {"entities": {"gene": [{"text": "fibrinogen", "start": 26, "end": 36}]}}, "schema": []}
{"input": "In a stepwise logistic regression analysis of SPT and RAST data, the occurrence of serum IgE antibodies to P. orbiculare had the highest explanatory value for current eczema.", "output": {"entities": {"gene": [{"text": "serum IgE antibodies to P. orbiculare", "start": 83, "end": 120}]}}, "schema": []}
{"input": "The examination was focused on assessment of different types of drusen, on evaluation of the development and incidence of risk factors leading to complications and loss of central vision.", "output": {"entities": {}}, "schema": []}
{"input": "They were then subjected to whole-body heat stress (water-perfused suits), and the 3 minutes of LBNP was repeated.", "output": {"entities": {}}, "schema": []}
{"input": "An NF1-related vitellogenin activator element mediates transcription from the estrogen-regulated Xenopus laevis vitellogenin promoter.", "output": {"entities": {"gene": [{"text": "NF1-related vitellogenin activator element", "start": 3, "end": 45}, {"text": "Xenopus laevis vitellogenin promoter", "start": 97, "end": 133}]}}, "schema": []}
{"input": "At the carboxyl terminus, deletion as far as residue 388 did not affect in vitro TRF. C assembly, although trans-activating activity was abolished.", "output": {"entities": {"gene": [{"text": "TRF. C", "start": 81, "end": 87}]}}, "schema": []}
{"input": "The effects of mean luminance were also measured and a general expression that would take them into account was derived.", "output": {"entities": {}}, "schema": []}
{"input": "Effect of hyperglycemia on pain threshold in alloxan-diabetic rats.", "output": {"entities": {}}, "schema": []}
{"input": "We have synthesized [7, 7-2H2]-19-OHA with high deuterium content and, together with [7, 7-2H2] A and [9, 11-2H2] estrone (E1), have developed a quantitative assay of serum level 19-OHA, A, and E1 using the gas chromatography/mass spectrometry-mass fragmentography method to monitor individual subjects throughout pregnancy.", "output": {"entities": {}}, "schema": []}
{"input": "Sequence analysis of these genes and their surrounding sequences are presented and compared with other known tRNA genes from plant mitochondria.", "output": {"entities": {}}, "schema": []}
{"input": "Experiments were performed in which brain-stem auditory-evoked responses (BAERs) were elicited by two types of pseudorandom pulse trains: maximum length sequences (MLS) and Legendre sequences (LGS).", "output": {"entities": {}}, "schema": []}
{"input": "The pseudolymphoma syndrome is a reversible reactive condition consisting of fever, lymphadenopathy and generalized rash.", "output": {"entities": {}}, "schema": []}
{"input": "In the local geomagnetic field, the animals preferred the SE-sector.", "output": {"entities": {}}, "schema": []}
{"input": "In the artificial lung, like in the natural lung and peripheral tissues, gas exchanges depend on several parameters: blood inlet conditions, blood flow rate, temperature, composition of the gas mixture used for ventilation, blood tissue perfusion, O2 consumption, etc.", "output": {"entities": {}}, "schema": []}
{"input": "Mean (+/-SE) measurements of clearance (24. 5 +/-2. 06 v 26. 5 +/-2. 05 mL/min/m2), half-life (5. 7 +/-0. 5 v 6. 4 +/-0. 5 hours), and volume of distribution (12. 4 +/-1. 1 v 13. 7 +/-1. 6 L/m2) were not significantly different in patients with jaundice when compared with controls.", "output": {"entities": {}}, "schema": []}
{"input": "Attitudes were found to be multidimensional, with similar dimensions being identified in both samples.", "output": {"entities": {}}, "schema": []}
{"input": "We conclude that DNA ploidy is a major objective prognostic factor and therapeutic determinant for endometrial carcinoma.", "output": {"entities": {}}, "schema": []}
{"input": "A semiautomatic digital system (Videoplan 2) was used.", "output": {"entities": {}}, "schema": []}
{"input": "Environmental factors were more important in the older cohorts (perhaps because of less reliable recall).", "output": {"entities": {}}, "schema": []}
{"input": "Dopamine SERS spectra from these electrodes are similar to those obtained at uncoated electrodes.", "output": {"entities": {}}, "schema": []}
{"input": "These findings indicate that hypergastrinemia induced by surgical removal of acid-producing mucosa in the rat has the same effects on oxyntical mucosal HDC activity, histamine concentration and ECL cell density as hypergastrinemia induced by continuous gastrin infusion or by long-term treatment with effective antisecretagogues.", "output": {"entities": {"gene": [{"text": "mucosal HDC", "start": 144, "end": 155}]}}, "schema": []}
{"input": "The order of the helicase motif and the nsP3 homology region in the RUB genome is reversed with respect to the alphavirus genome indicating that a genetic rearrangement has occurred during the evolution of these viruses.", "output": {"entities": {"gene": [{"text": "helicase motif", "start": 17, "end": 31}, {"text": "nsP3 homology region", "start": 40, "end": 60}]}}, "schema": []}
{"input": "The results suggest followings--1) both eosinophils and neutrophils participate in hypersecretion of type Ib in atopic cases, and only eosinophils in non-atopic cases.", "output": {"entities": {}}, "schema": []}
{"input": "There were 5 treatments: control (C); a wooden surround in one rear corner of the cage (S); a fiberglass rollaway hollow in one rear corner of the cage (H); a hollow and a surround (H/S); a nest box attached to the back of the cage, containing a hollow (N).", "output": {"entities": {}}, "schema": []}
{"input": "While no significant differences in the tensile responses or failure characteristics were noted for irradiated and nonirradiated grafts in the drip, in the bath environment the nonirradiated tissues had greater strength and modulus.", "output": {"entities": {}}, "schema": []}
{"input": "The patient was treated with benzathine penicillin, 2, 400, 000 U weekly for three weeks.", "output": {"entities": {}}, "schema": []}
{"input": "A consensus binding site for the transcription factor SP1 was identified in intron As downstream of the proenkephalin germ cell cap site region.", "output": {"entities": {"gene": [{"text": "SP1", "start": 54, "end": 57}, {"text": "proenkephalin germ cell cap site region", "start": 104, "end": 143}]}}, "schema": []}
{"input": "This proposed method is similar in principle to the sets technique but is shown to have much better expected time to alarm properties.", "output": {"entities": {}}, "schema": []}
{"input": "Drug and personnel costs were reduced when batch manufacturing with 40-mL multidose vials was compared with extemporaneous compounding with unit-dose vials.", "output": {"entities": {}}, "schema": []}
{"input": "Changes in prognosis of twin births over 20 years.", "output": {"entities": {}}, "schema": []}
{"input": "Dermal toxicity and carcinogenicity of 4-vinyl-1-cyclohexene diepoxide in Fischer rats and B6C3F1 mice.", "output": {"entities": {}}, "schema": []}
{"input": "Per kg FFM SMR was almost restored to baseline values for the EX group, whereas the non-exercising subjects still showed depressed values (EX 3. 7 per cent and D + DE 15. 8 per cent lower than before treatment; P less than 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "MK-927: a topically active ocular hypotensive carbonic anhydrase inhibitor.", "output": {"entities": {"gene": [{"text": "carbonic anhydrase", "start": 46, "end": 64}]}}, "schema": []}
{"input": "PCR-derived fragments were used as probes for the isolation of the U3 snRNA genes from a genomic library of Arabidopsis.", "output": {"entities": {"gene": [{"text": "U3 snRNA genes", "start": 67, "end": 81}]}}, "schema": []}
{"input": "The transcriptional unit spans a chromosomal region of about 55 kilobase pairs (kbp).", "output": {"entities": {}}, "schema": []}
{"input": "100 of the patients who would have died survive.", "output": {"entities": {}}, "schema": []}
{"input": "The effects of tap (TW) or carbonated (CW) water on arterial pH, partial pressure of carbon dioxide (PCO2) and plasma lactate were determined in heat-stressed broilers.", "output": {"entities": {}}, "schema": []}
{"input": "Transient expression of human and chicken progesterone receptors does not support alternative translational initiation from a single mRNA as the mechanism generating two receptor isoforms.", "output": {"entities": {"gene": [{"text": "human and chicken progesterone receptors", "start": 24, "end": 64}]}}, "schema": []}
{"input": "The Community Adjustment Scale provided outcome data related to the subjects' degree of productivity, ability to maintain close relationships, and presence/absence of symptomatology an average of 32 years after initial admission.", "output": {"entities": {}}, "schema": []}
{"input": "However, at 18 months of age, significantly higher levels of IgG1 (P less than 0. 05) and of IgG4 (P less than 0. 01) were found in infants with an elevated IgE (greater than or equal to 8. 0 kU/l) than in those with a lower level.", "output": {"entities": {"gene": [{"text": "IgG1", "start": 61, "end": 65}, {"text": "IgG4", "start": 93, "end": 97}, {"text": "IgE", "start": 157, "end": 160}]}}, "schema": []}
{"input": "The protein sequence contains seven potential N-linked glycosylation sites and a threonine/serine-rich region which is a potential site for attachment of O-linked carbohydrate.", "output": {"entities": {}}, "schema": []}
{"input": "Thus adaptation to continuous mild stress has a potent antiarrhythmic effect which occurs due to the increased vagal tone.", "output": {"entities": {}}, "schema": []}
{"input": "The eluent from the column was mixed with the chemiluminescent solution containing lucigenin and Triton X-100 and a 0. 28 M KOH solution by pumps and monitored by a chemiluminescence detector.", "output": {"entities": {"gene": [{"text": "lucigenin", "start": 83, "end": 92}]}}, "schema": []}
{"input": "On histologic examination the cuboidal epithelium of the mucous membrane was found to be changed into columnar epithelium, with uneven distribution of enlarged nuclei in the vacuolized cytoplasm.", "output": {"entities": {}}, "schema": []}
{"input": "These results suggest an increased risk of developing cancer among polyp patients and the possibility of prophylactic effect of polypectomy against subsequent cancer.", "output": {"entities": {}}, "schema": []}
{"input": "The same trend was noted between YG 4. 5 heifers and YG 5. 5 steers, indicating a sex-related deposition of seam fat in fed cattle.", "output": {"entities": {}}, "schema": []}
{"input": "The nucleotide sequence consists of 48 bp of 5'-end non-coding region, 1695 bp of coding region and 212 bp of 3'-end non-coding region including a 20 bp poly (A) tail.", "output": {"entities": {}}, "schema": []}
{"input": "Toxicities included: nausea/vomiting (69%), headache (25%), chills (69%), pain at tumor sites (63%), hypotension (31%), and hypertension (38%).", "output": {"entities": {}}, "schema": []}
{"input": "The results also showed that although oyster shell supplementation generally increased alkaline phosphatase activity, bone mineralization was relatively uninfluenced as judged by the low coefficients of variation (CV) of 3. 14-3. 51% and 3. 39-4. 82% for calcium and phosphorus content in the femur and tibia respectively.", "output": {"entities": {"gene": [{"text": "alkaline phosphatase", "start": 87, "end": 107}]}}, "schema": []}
{"input": "In 6 of 24 infants studied (27th-40th weeks of gestation), acquired and congenital structural anomalies of the airways were detected with an ultrathin flexible fiberscope (Olympus PF18 S, 1. 8 mm).", "output": {"entities": {}}, "schema": []}
{"input": "Fatal encephalitis in a patient with chronic graft-versus-host disease.", "output": {"entities": {}}, "schema": []}
{"input": "Compared to its counterpart in the GPB gene, exon 3 of the GPE gene contains several point mutations, an insertion of 24 bp, and a stop codon which shortens the reading frame.", "output": {"entities": {"gene": [{"text": "GPB gene", "start": 35, "end": 43}, {"text": "GPE gene", "start": 59, "end": 67}]}}, "schema": []}
{"input": "Molecular cloning of a cDNA encoding rat NADH-cytochrome b5 reductase and the corresponding gene.", "output": {"entities": {"gene": [{"text": "rat NADH-cytochrome b5 reductase", "start": 37, "end": 69}]}}, "schema": []}
{"input": "The results corroborate the idea that the structure of relaxation curves contains information on the distance scale and on the architecture of the pore space, even if it is difficult to extract it without ambiguities.", "output": {"entities": {}}, "schema": []}
{"input": "Serotonin 5-HT2 receptor binding on blood platelets as a state dependent marker in major affective disorder.", "output": {"entities": {"gene": [{"text": "Serotonin 5-HT2 receptor", "start": 0, "end": 24}]}}, "schema": []}
{"input": "Although% BF was correlated with all the BMIs (r = 0. 60-0. 82), applying objective definitions of obesity based on BMIs or% BF by densitometry often produced conflicting results.", "output": {"entities": {}}, "schema": []}
{"input": "The RF values correlated well with the angiographic semiquantitative scale of severity of aortal insufficiency (r = 0. 805; p less than 0. 001), although they enabled the authors only to make a partial differentiation of haemodynamically severe regurgitations and mild or insignificant ones.", "output": {"entities": {}}, "schema": []}
{"input": "Promoter elements include an atypical TATA box (GTTA), one CCAAT box much further from the initiation site, three reverse compliments of CCAAT (ATTGG), and two pyrimidine-rich nucleotide stretches.", "output": {"entities": {}}, "schema": []}
{"input": "The cloned genes were identified in genetic libraries by hybridization screening using four deoxyoligonucleotide probes which corresponded to the partial amino acid sequence of the purified enzyme.", "output": {"entities": {}}, "schema": []}
{"input": "The pattern for catalytic zinc sites included two ligands close in sequence, a sequence-distant ligand, and a main-chain hydrogen bond joining two ligands.", "output": {"entities": {}}, "schema": []}
{"input": "Results of the long-term observation and treatment of patients with arterial hypertension", "output": {"entities": {}}, "schema": []}
{"input": "Eucaryotic transcription factors that stimulate RNA polymerase II by increasing the efficiency of elongation of specifically or randomly initiated RNA chains have been isolated and characterized.", "output": {"entities": {"gene": [{"text": "RNA polymerase II", "start": 48, "end": 65}]}}, "schema": []}
{"input": "Sprague-Dawley newborn rats (n = 85) breathed 100% oxygen (O2) or room air (RA) during the first 8 days of life, and then RA.", "output": {"entities": {}}, "schema": []}
{"input": "The Lm increased and the alveoli/mm2 and elastic recoil pressure decreased.", "output": {"entities": {}}, "schema": []}
{"input": "In Experiment II, as performing moderate supine cycling (55% VO2 max) for 50 minutes under several LBNP conditions in 5 sedentary women, there were correspondingly similar changing manners of the cardiovascular adjustments to each of the phases given in Experiment I.", "output": {"entities": {}}, "schema": []}
{"input": "Commercially available formulations of 2. 5% and 5% lambdacyhalothrin can be diluted either with water for ULV cold aerosol space-spraying or with diesel/kerosene for thermal fogging at recommended application rates of 0. 5-1 g ai/ha for mosquito control and 2 g ai/ha for housefly control.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, this reading frame was concluded to encode the precursor of mitochondrial fumarase.", "output": {"entities": {"gene": [{"text": "mitochondrial fumarase", "start": 66, "end": 88}]}}, "schema": []}
{"input": "Sequence analysis indicates that in addition to an ATA and GC box, this region contains domains that have been implicated in the regulation of other muscle-specific genes: a CArG box at-91 bp; myocyte-specific enhancer-binding nuclear factor 1 binding site homologies at-58,-535, and-583 bp; and a muscle-CAAT consensus sequence at-394 bp relative to the cap site.", "output": {"entities": {"gene": [{"text": "myocyte-specific enhancer-binding nuclear factor 1 binding site", "start": 193, "end": 256}]}}, "schema": []}
{"input": "The trk-2h oncogene, isolated from the human breast carcinoma cell line MDA-MB 231 by genomic DNA-transfection into NIH3T3 cells, consists of the trk proto-oncogene receptor kinase domain fused to a N-terminal 41 amino acid activating sequence (Kozma, S. C., Redmond, S. M. S., Xiao-Chang, F., Saurer, S. M., Groner, B. and Hynes, N. E.", "output": {"entities": {"gene": [{"text": "trk-2h oncogene", "start": 4, "end": 19}, {"text": "trk proto-oncogene receptor kinase domain", "start": 146, "end": 187}]}}, "schema": []}
{"input": "Antibodies raised against a bacterially produced beta gal-trk receptor kinase fusion protein recognized a 44 kd phosphoprotein phosphorylated on serine, threonine and tyrosine in extracts of trk-2h transformed NIH3T3 cells.", "output": {"entities": {"gene": [{"text": "beta gal", "start": 49, "end": 57}, {"text": "trk", "start": 58, "end": 61}, {"text": "trk-2h", "start": 191, "end": 197}]}}, "schema": []}
{"input": "Since very recent scanning-deletion analysis indicates that there is a critical region for activity near Cys-118 and that Cys-118 is necessary for maximal activity, we conclude that the Cys-118 residue is necessary for proper glycosylation and maximal biologic activity of GM-CSF.", "output": {"entities": {"gene": [{"text": "GM-CSF", "start": 273, "end": 279}]}}, "schema": []}
{"input": "Molecular and functional characterization of the promoter of ETS2, the human c-ets-2 gene.", "output": {"entities": {"gene": [{"text": "ETS2", "start": 61, "end": 65}, {"text": "c-ets-2", "start": 77, "end": 84}]}}, "schema": []}
{"input": "Information about immunologic drug interactions is needed by pharmacists to make rational drug-use decisions.", "output": {"entities": {}}, "schema": []}
{"input": "Branch occlusion of Heubner' s artery, or perforators from the proximal anterior or middle cerebral arteries were the posited mechanism of infarction.", "output": {"entities": {}}, "schema": []}
{"input": "All ABFI-binding sites, regardless of origin, provided weak UAS function in vivo when examined in test plasmids.", "output": {"entities": {"gene": [{"text": "ABFI-binding sites", "start": 4, "end": 22}]}}, "schema": []}
{"input": "An examination of the properties of sequences surrounding ARS1 left open the possibility that ABFI enhances the initiation of DNA replication at ARS1 by transcriptional activation.", "output": {"entities": {"gene": [{"text": "ABFI", "start": 94, "end": 98}]}}, "schema": []}
{"input": "Likewise, whether or not the hypotensive action of converting enzyme inhibitors is age-related is as yet unknown.", "output": {"entities": {}}, "schema": []}
{"input": "Polyclonal antiserum generated to the fusion protein was capable of detecting 42-and 46-kilodalton polypeptides from virus particles; both polypeptides were also shown to contain HBsAg determinants.", "output": {"entities": {"gene": [{"text": "HBsAg determinants", "start": 179, "end": 197}]}}, "schema": []}
{"input": "Role of superoxide dismutase in cellular oxidative processes and method of its determination in biological materials", "output": {"entities": {"gene": [{"text": "superoxide dismutase", "start": 8, "end": 28}]}}, "schema": []}
{"input": "At maximum photosensitivity the inhibitory amino acids gamma-aminobutyric acid and taurine were lower, and those of asparagine (metabolite of the excitatory amino acid aspartate) were higher, than when the animals were not photosensitive.", "output": {"entities": {}}, "schema": []}
{"input": "The priming activity of DNA incised by either of the Drosophila enzymes can be enhanced, however, by an additional incubation with E. coli endonuclease IV, which is known to cleave depurinated DNA on the 5'-side of an apurinic site.", "output": {"entities": {"gene": [{"text": "E. coli endonuclease IV", "start": 131, "end": 154}]}}, "schema": []}
{"input": "A.", "output": {"entities": {}}, "schema": []}
{"input": "Therefore, in conjunction with a positive pregnancy test and the patient' s clinical history, a severely depressed or absent serum PAPP-A level may aid in the diagnosis of extrauterine pregnancy.", "output": {"entities": {"gene": [{"text": "PAPP-A", "start": 131, "end": 137}]}}, "schema": []}
{"input": "The levels of both MAP1-specific and MAP2-specific mRNAs decline in the postnatal developing brain; the level of MAP1-specific mRNA also increases slightly in rat PC12 cells upon exposure to nerve growth factor.", "output": {"entities": {"gene": [{"text": "MAP1-specific and MAP2-specific mRNAs", "start": 19, "end": 56}, {"text": "MAP1-specific mRNA", "start": 113, "end": 131}, {"text": "nerve growth factor", "start": 191, "end": 210}]}}, "schema": []}
{"input": "The cDNAs cross-hybridize with genomic sequences in rat, human, and chicken DNA, but not with DNA from frog, Drosophila, or sea urchin.", "output": {"entities": {}}, "schema": []}
{"input": "Colorimetric method of determining glycerin in the blood", "output": {"entities": {}}, "schema": []}
{"input": "Deletion analysis was carried out within a part of the 5'-flanking region showing homology to the upstream region of the yeast CYC1 gene.", "output": {"entities": {"gene": [{"text": "yeast CYC1 gene", "start": 121, "end": 136}]}}, "schema": []}
{"input": "The N1 and P2 were comparable in amplitude and both had prolonged refractory periods.", "output": {"entities": {}}, "schema": []}
{"input": "Tolerance to fenfluramine anorexia: fact or fiction? Recent findings in this laboratory with regard to tolerance to fenfluramine anorexia are reviewed with respect to generality of the behavioural phenomenon.", "output": {"entities": {}}, "schema": []}
{"input": "In 30 dogs the left limb (tail) of the pancreas was removed but left in the abdominal cavity after cessation of blood flow to produce warm ischemia for 30, 60, and 120 min (10 dogs at each time point), and then was flushed with cold Ringers' lactate and transplanted to the iliac vessels.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, beta 2-adrenoceptor sensitivity appears to be unaltered in BHT.", "output": {"entities": {"gene": [{"text": "beta 2-adrenoceptor", "start": 13, "end": 32}]}}, "schema": []}
{"input": "These results suggest that the negative inotropic action of nicorandil is caused by inhibition of Ca influx and intracellular mobilization of Ca.", "output": {"entities": {}}, "schema": []}
{"input": "Comparison of elastase-1 with amylase, lipase, and trypsin-like immunoreactivity in the diagnosis of acute pancreatitis.", "output": {"entities": {"gene": [{"text": "elastase-1", "start": 14, "end": 24}, {"text": "amylase", "start": 30, "end": 37}, {"text": "lipase", "start": 39, "end": 45}, {"text": "trypsin", "start": 51, "end": 58}]}}, "schema": []}
{"input": "A probe evoked potentials procedure was used to assess the relative engagement of both cerebral hemispheres during a language task in the following four groups of dextral adults: left hemisphere (LH)-damaged aphasics recovering from stroke, dysarthrics, right hemisphere (RH)-damaged nonaphasic patients, and normal control subjects.", "output": {"entities": {}}, "schema": []}
{"input": "Mucolipidosis type IV: clinical spectrum and natural history.", "output": {"entities": {}}, "schema": []}
{"input": "Two of the three groups were administered dauricine, as a new calcium channel blocker, and verapamil, as a generally recognized calcium channel blocker, respectively, from 15 minutes pre-bypass to the end of the bypass procedure (a period of 95 minutes).", "output": {"entities": {}}, "schema": []}
{"input": "No reflow occurred in approximately 30 percent of the muscle microvasculature upon reperfusion.", "output": {"entities": {}}, "schema": []}
{"input": "Lysozyme activity was evidently increased as well in undiluted as in diluted sera in all our tested patients.", "output": {"entities": {"gene": [{"text": "Lysozyme", "start": 0, "end": 8}]}}, "schema": []}
{"input": "The first involved measurements of the steady state levels of mRNAs for subunit 5 of cytochrome oxidase and the beta subunit of F1 ATPase in wild type and in a hem2 mutant.", "output": {"entities": {"gene": [{"text": "cytochrome oxidase", "start": 85, "end": 103}, {"text": "F1 ATPase", "start": 128, "end": 137}, {"text": "hem2 mutant", "start": 160, "end": 171}]}}, "schema": []}
{"input": "A 5. 8S-like structure is present within the 5'-terminal region of all three fungal mitochondrial LSU rRNAs; in contrast, no 4. 5S-like structure is evident at the 3' end of these molecules.", "output": {"entities": {"gene": [{"text": "5. 8S-like structure", "start": 2, "end": 22}, {"text": "fungal mitochondrial LSU rRNAs", "start": 77, "end": 107}, {"text": "4. 5S-like structure", "start": 125, "end": 145}]}}, "schema": []}
{"input": "The recovery of labelled methoxydextrane is 98 +/-7%.", "output": {"entities": {}}, "schema": []}
{"input": "ASL-8123 demonstrated weak competitive beta-adrenoreceptor blocking activity in isolated guinea pig right atria with a pA2 of 3. 73 +/-0. 07; no agonist-like activity was observed in this tissue at concentrations of ASL-8123 from 3 X 10 (-5) to 1 X 10 (-2) M.", "output": {"entities": {"gene": [{"text": "beta-adrenoreceptor", "start": 39, "end": 58}]}}, "schema": []}
{"input": "We discuss the results in relation to previous systems for parcellating the posterior ectosylvian gyrus of the cat and consider the possibility that divisions of the feline posterior ectosylvian gyrus correspond directly to areas making up the superior temporal gyrus in primates.", "output": {"entities": {}}, "schema": []}
{"input": "The 4-AP (4-20 mM) effect resulted in a decrease of the sensory activity, which was fully restored by TEA or Ba2 +.", "output": {"entities": {}}, "schema": []}
{"input": "Hybridization of a probe from this region to electrophoretic blots of RNAs from different human tissues showed a predominant 2. 8-kilobase (kb) message accompanied by weaker bands 4. 1 and 2. 1 kb in size.", "output": {"entities": {}}, "schema": []}
{"input": "Prognosis of asymptomatic multiple myeloma.", "output": {"entities": {}}, "schema": []}
{"input": "A new method for the quantitative analysis of sleep spindles during continuous overnight EEG recordings.", "output": {"entities": {}}, "schema": []}
{"input": "Svensson et al.", "output": {"entities": {}}, "schema": []}
{"input": "Endogenous release of neuronal serotonin and 5-hydroxyindoleacetic acid in the caudate-putamen of the rat as revealed by intracerebral dialysis coupled to high-performance liquid chromatography with fluorimetric detection.", "output": {"entities": {}}, "schema": []}
{"input": "In this report we describe for the first time the complete primary structure of type X collagen, based on cloning and sequencing of cDNA and genomic DNA.", "output": {"entities": {"gene": [{"text": "type X collagen", "start": 80, "end": 95}]}}, "schema": []}
{"input": "Viable flap areas were established following vascular pedicle ligation (both vessels or only artery or vein), on the third day after flap replantation in both island and free flaps.", "output": {"entities": {}}, "schema": []}
{"input": "The size discrepancy is not due to glycosylation or phosphorylation of Ag35 but may result from a proline-rich sequence which occurs in this polypeptide.", "output": {"entities": {"gene": [{"text": "Ag35", "start": 71, "end": 75}]}}, "schema": []}
{"input": "A 9. 5-kb KpnI-SalI fragment, where all the DNA changes associated with su (Hw) mutations were mapped, was able to rescue the su (Hw) mutant phenotype after P-element-mediated germ-line transformation.", "output": {"entities": {"gene": [{"text": "KpnI", "start": 10, "end": 14}, {"text": "SalI", "start": 15, "end": 19}, {"text": "su (Hw) mutations", "start": 72, "end": 89}, {"text": "su (Hw) mutant", "start": 126, "end": 140}]}}, "schema": []}
{"input": "The corticosterone synthesis inhibitor metyrapone (75 mg/kg i. p.) was given to attenuate the rise of corticosterone to a level typical of stressed males.", "output": {"entities": {}}, "schema": []}
{"input": "The effects of L655, 240, a selective thromboxane and prostaglandin endoperoxide antagonist, on ischemia-and reperfusion-induced cardiac arrhythmias.", "output": {"entities": {}}, "schema": []}
{"input": "In 10 pentobarbitalized dogs, plasma viscosity (Ep) was raised fourfold while apparent blood viscosity (Ea) increased about twofold by two steps of exchange transfusion of 200 ml of plasma with plasma containing high molecular weight dextran (mol wt 500, 000, 20% wt/vol).", "output": {"entities": {}}, "schema": []}
{"input": "The small IGF-binding protein is abundant in human amniotic fluid.", "output": {"entities": {"gene": [{"text": "small IGF-binding protein", "start": 4, "end": 29}]}}, "schema": []}
{"input": "Serum prostatic acid phosphatase levels showed a significantly weaker correlation with cancer volume (r equals 0. 51) and every other pathological parameter.", "output": {"entities": {"gene": [{"text": "prostatic acid phosphatase", "start": 6, "end": 32}]}}, "schema": []}
{"input": "The investigation was thereafter continued in an open fashion by administering a single 10 mg dose of the MAO-B inhibitor deprenyl to the same subjects.", "output": {"entities": {"gene": [{"text": "MAO-B", "start": 106, "end": 111}]}}, "schema": []}
{"input": "Their studies have revealed a considerable increase of CSF AP activity in purulent meningitides whereas in serous meningitides it grows negligibly.", "output": {"entities": {"gene": [{"text": "CSF AP", "start": 55, "end": 61}]}}, "schema": []}
{"input": "A cDNA encoding a new human lymphocyte cell surface molecule has been isolated and shown to identify a fourth member of a recently discovered family of adhesion proteins.", "output": {"entities": {}}, "schema": []}
{"input": "Dopamine caused a prominent potassium efflux measured as 86Rb + efflux from control glands, but was without effect in denervated glands.", "output": {"entities": {}}, "schema": []}
{"input": "This approach was examined utilizing the fetal protein, HGB F.", "output": {"entities": {"gene": [{"text": "HGB F", "start": 56, "end": 61}]}}, "schema": []}
{"input": "The investigation was apt at studying the relationship between urinary metabolites of serotonin and catecholamine (5-HIAA and VMA), T-cells (OKT3 +), T-helper (OKT4 +), T-suppressor (OKT8 +) and B-cells (EAC-rosette forming cells) in normal (10 subjects, 1 female, 9 male, age 21 +/-5 years) and stress administered subjects (20 subjects, 3 female, 17 male, age 20 +/-4 years).", "output": {"entities": {"gene": [{"text": "OKT3 +", "start": 141, "end": 147}, {"text": "OKT4 +", "start": 160, "end": 166}, {"text": "OKT8 +", "start": 183, "end": 189}]}}, "schema": []}
{"input": "Their hydropathic plots are very similar and both possess three hydrophobic segments that are likely alpha-helical transmembrane segments.", "output": {"entities": {}}, "schema": []}
{"input": "Angiotensin converting enzyme inhibitors enhance the antihypertensive efficacy of diuretics and blunt or prevent adverse metabolic effects.", "output": {"entities": {"gene": [{"text": "Angiotensin converting enzyme", "start": 0, "end": 29}]}}, "schema": []}
{"input": "In addition to the significant reduction in blood pressure, the angiotensin converting enzyme (ACE) inhibitor ramipril caused a significant regression of pathologic left ventricular hypertrophy demonstrated by magnetic resonance imaging and echocardiography.", "output": {"entities": {"gene": [{"text": "angiotensin converting enzyme", "start": 64, "end": 93}, {"text": "ACE", "start": 95, "end": 98}]}}, "schema": []}
{"input": "The ratio of radioactivity in tumour compared with normal tissue (T: N ratio) was determined after simultaneously injecting microspheres into the portal and arterial circulation of each animal.", "output": {"entities": {}}, "schema": []}
{"input": "The mRNA was converted to cDNA and amplified by the polymerase chain reaction technique.", "output": {"entities": {}}, "schema": []}
{"input": "Tissue necrosis was evaluated using triphenyltetrazolium staining and was related to two major baseline predictors of infarct size: anatomic risk zone size and coronary collateral flow.", "output": {"entities": {}}, "schema": []}
{"input": "To study the retinal surface in the human eye in normal and diseased states we used laser scanning tomography.", "output": {"entities": {}}, "schema": []}
{"input": "Previously, we reported the sequence of the gene encoding human K14 (D.", "output": {"entities": {"gene": [{"text": "gene encoding human K14", "start": 44, "end": 67}]}}, "schema": []}
{"input": "Cotransfection of either construct with plasmids encoding PKI (1-31) inhibits cAMP-stimulated but not basal-or phorbol ester-stimulated expression.", "output": {"entities": {"gene": [{"text": "PKI (1-31)", "start": 58, "end": 68}]}}, "schema": []}
{"input": "Sequence analysis of the 5' flanking region revealed several GC boxes but no identifiable TATA box.", "output": {"entities": {}}, "schema": []}
{"input": "The underlying cirrhosis was alcoholic in 11 (53. 3%), cryptogenic in 5 (23. 8%), and hepatitis B chronic infection related in 5 (23. 8%).", "output": {"entities": {}}, "schema": []}
{"input": "Once P-450scc mRNA is induced as a consequence of the LH/hCG surge it is constitutively maintained by luteinized cells in vivo (0-4 days) and in vitro (0-9 days) in the absence of gonadotropins, is susceptible to modulation by prolactin and is no longer regulated by cAMP.", "output": {"entities": {"gene": [{"text": "P-450scc mRNA", "start": 5, "end": 18}, {"text": "LH", "start": 54, "end": 56}, {"text": "hCG", "start": 57, "end": 60}, {"text": "gonadotropins", "start": 180, "end": 193}, {"text": "prolactin", "start": 227, "end": 236}]}}, "schema": []}
{"input": "Similarly, a human but not a bovine alpha transgene was expressed in placenta in transgenic mice.", "output": {"entities": {"gene": [{"text": "bovine alpha transgene", "start": 29, "end": 51}]}}, "schema": []}
{"input": "A rapid staining technique for Leishmania parasites in splenic aspirate smears.", "output": {"entities": {}}, "schema": []}
{"input": "NIK-244 suppressed coronary ligation-and digitalis-induced arrhythmias, and the minimum effective plasma concentrations for arrhythmias induced by 24-h and 48-h coronary ligation and digitalis were 0. 41 +/-0. 10 (by 1 mg/kg i. v.), 0. 70 +/-0. 13 (by 1 mg/kg i. v.), and 0. 21 +/-0. 08 (by 0. 5 mg/kg i. v.) microgram/ml, respectively (mean +/-SD of the mean, n = 6).", "output": {"entities": {}}, "schema": []}
{"input": "In TNF-resistant T24 bladder carcinoma cells, TNF failed to alter EGF-R tyrosine protein kinase activity although both EGF and phorbol ester were shown to modulate the enzymatic activity of the receptor in these cells.", "output": {"entities": {"gene": [{"text": "TNF", "start": 3, "end": 6}, {"text": "TNF", "start": 46, "end": 49}, {"text": "EGF-R tyrosine protein kinase", "start": 66, "end": 95}, {"text": "EGF", "start": 119, "end": 122}]}}, "schema": []}
{"input": "Thus, phosphodiesterase inhibitors that produce an opiate quasi-withdrawal syndrome potentiate interoceptive stimuli and weight loss associated with the withdrawal syndrome precipitated by naltrexone in morphine-dependent rats.", "output": {"entities": {}}, "schema": []}
{"input": "The diagnostic value of blood serum and urinary amylase, lipase, and trypsin in exacerbations of chronic relapsing pancreatitis is discussed.", "output": {"entities": {"gene": [{"text": "urinary amylase", "start": 40, "end": 55}, {"text": "lipase", "start": 57, "end": 63}, {"text": "trypsin", "start": 69, "end": 76}]}}, "schema": []}
{"input": "On the basis of the mechanism of action, two groups of inodilators are distinguished, the phosphodiesterase inhibitors and the dopaminergic agents.", "output": {"entities": {}}, "schema": []}
{"input": "Structural organization and expression of the mouse estrogen receptor.", "output": {"entities": {"gene": [{"text": "mouse estrogen receptor", "start": 46, "end": 69}]}}, "schema": []}
{"input": "Intravenous gamma globulins", "output": {"entities": {}}, "schema": []}
{"input": "Following chondroitinase AC and ABC digestion, staining reactions suggested that the highest levels of dermatan sulfate were in the diabetes resistant group (p less than 0. 001 compared to diabetic, p less than 0. 001 compared to diabetes prone) and the highest levels of chondroitin sulfates were in the diabetes prone group (p less than 0. 001).", "output": {"entities": {"gene": [{"text": "chondroitinase AC and ABC", "start": 10, "end": 35}]}}, "schema": []}
{"input": "Myocardial perfusion was evaluated using the enhanced gray level after contrast injection, and the level was compared with the morphology and degree of collateral development.", "output": {"entities": {}}, "schema": []}
{"input": "Once NGF administration is proven effective it will be possible to develop alternative ways of NGF administration.", "output": {"entities": {"gene": [{"text": "NGF", "start": 5, "end": 8}, {"text": "NGF", "start": 95, "end": 98}]}}, "schema": []}
{"input": "During the program' s use at the RSNA meeting, the program selected the correct diagnosis in the top five 22% of the time.", "output": {"entities": {}}, "schema": []}
{"input": "Immunoglobulin light chain (IgL) diversity is generated in the chicken by recombination between the single functional variable (VL) and joining (JL) gene segments and subsequent somatic diversification of the rearranged VL region.", "output": {"entities": {"gene": [{"text": "Immunoglobulin light chain", "start": 0, "end": 26}, {"text": "IgL", "start": 28, "end": 31}, {"text": "VL", "start": 128, "end": 130}, {"text": "JL", "start": 145, "end": 147}, {"text": "VL", "start": 220, "end": 222}]}}, "schema": []}
{"input": "The results were as follows: 1) Total integrated EMG activity of FB group was approximately equal in any occluded position, whereas that of CG and GF group varied from position to position.", "output": {"entities": {}}, "schema": []}
{"input": "Muscle action potential and masticatory rhythm of anterior temporal and masseter muscles in children and adults", "output": {"entities": {}}, "schema": []}
{"input": "The thrombolytic effects of native tissue-type plasminogen activator (AK-124) on experimental canine coronary thrombosis.", "output": {"entities": {"gene": [{"text": "tissue-type plasminogen activator", "start": 35, "end": 68}, {"text": "AK-124", "start": 70, "end": 76}]}}, "schema": []}
{"input": "O2 and CO2 in the tracheostomy tube were continuously monitored by mass spectrometry using a special sample-hold phase-locked sampling technique.", "output": {"entities": {}}, "schema": []}
{"input": "Enzyme-linked immunosorbent assay for screening aflatoxin B1 in cottonseed products and mixed feed: collaborative study.", "output": {"entities": {}}, "schema": []}
{"input": "However, experiments with S1 mapping of in vivo transcripts, gene disruptions in the alpha region, and a single-copy transcriptional fusion vector all suggested that these possible promoters were largely inactive during logarithmic growth, that the major promoter for the alpha operon lay upstream from the region cloned, and that the genes in the IF1 to L17 interval were cotranscribed.", "output": {"entities": {"gene": [{"text": "S1", "start": 26, "end": 28}, {"text": "IF1", "start": 348, "end": 351}, {"text": "L17", "start": 355, "end": 358}]}}, "schema": []}
{"input": "Two specific DNA-protein complexes were identified in gel retardation assays using HeLa cell nuclear extracts and an oligonucleotide probe spanning the footprinted region.", "output": {"entities": {}}, "schema": []}
{"input": "After transfection, specific TSH beta promoter activity was evident in both TRH-responsive pituitary-derived GH3 and primary pituitary cell cultures.", "output": {"entities": {"gene": [{"text": "TSH beta promoter", "start": 29, "end": 46}, {"text": "TRH", "start": 76, "end": 79}]}}, "schema": []}
{"input": "In transformed E. coli, constitutive CAT expression is maintained when as little as 0. 3 kilobase of DNA from the 3' end of the 1. 6-kilobase segment is inserted in the correct orientation in front of the CAT gene.", "output": {"entities": {"gene": [{"text": "constitutive CAT", "start": 24, "end": 40}, {"text": "CAT gene", "start": 205, "end": 213}]}}, "schema": []}
{"input": "Lowering of the renal blood flow alters the glomerular and tubular excretion processes.", "output": {"entities": {}}, "schema": []}
{"input": "Tonometry of blood samples from patients may also be used in the determination of acid-base quantities and hemoglobin-oxygen affinity e. g. p50.", "output": {"entities": {"gene": [{"text": "hemoglobin", "start": 107, "end": 117}]}}, "schema": []}
{"input": "100 and 14 p.", "output": {"entities": {}}, "schema": []}
{"input": "Here, we alter the dimerization specificity of Fos by precisely replacing its leucine zipper with that from GCN4.", "output": {"entities": {"gene": [{"text": "Fos", "start": 47, "end": 50}, {"text": "GCN4", "start": 108, "end": 112}]}}, "schema": []}
{"input": "Fourth, sometime between 4 and 24 hours of recovery is necessary to reverse the effect of chronic hypoxia on cerebral blood flow.", "output": {"entities": {}}, "schema": []}
{"input": "Kindling of the primary visual cortex (VC) was compared with that of the amygdala in cats.", "output": {"entities": {}}, "schema": []}
{"input": "Abundant infiltration of lymphocytes and plasma cells was also wide-spread beneath the carcinoma in situ, together with the lymphoid follicles.", "output": {"entities": {}}, "schema": []}
{"input": "These case reports provide further evidence that LiCO3 can be a useful medication in the treatment of aggressive behavior and affective instability after brain injury, but that it has significant potential for neurotoxicity in this population, particularly when used in conjunction with neuroleptic agents.", "output": {"entities": {}}, "schema": []}
{"input": "Among 100 cases of post-transfusion hepatitis, 10 are due to the hepatitis B virus (despite systematic search for HBs Ag), 89 are due to one of the non-A non-B viruses (not detectable by specific serological tests) and 1 to several viruses, specially CMV.", "output": {"entities": {"gene": [{"text": "HBs Ag", "start": 114, "end": 120}]}}, "schema": []}
{"input": "Recessive lethal mutations were isolated based upon failure to complement the recessive lethality of Df (3L) RR2, a deletion of the DRE region that removes 16-18 polytene chromosome bands.", "output": {"entities": {}}, "schema": []}
{"input": "Current status and future perspectives", "output": {"entities": {}}, "schema": []}
{"input": "K.", "output": {"entities": {}}, "schema": []}
{"input": "A 215-base-pair (bp) region of the mouse MOPC 41 kappa light-chain immunoglobulin gene enhancer has been analyzed for specific binding of lymphoid and nonlymphoid nuclear factors.", "output": {"entities": {"gene": [{"text": "mouse MOPC 41 kappa light-chain immunoglobulin gene enhancer", "start": 35, "end": 95}]}}, "schema": []}
{"input": "Follow-up study showed 85% of these patients with effectiveness.", "output": {"entities": {}}, "schema": []}
{"input": "The other patients continued the trial with single daily doses of monotherapy.", "output": {"entities": {}}, "schema": []}
{"input": "Neonatal Chagas disease: laboratory diagnosis during the first year of life", "output": {"entities": {}}, "schema": []}
{"input": "Using mutated IL2R alpha promoter constructs in transient transfection and DNA binding assays, we now demonstrate that sequences located immediately upstream and downstream of the kappa B enhancer also contribute to the regulation of IL2R alpha gene expression.", "output": {"entities": {"gene": [{"text": "mutated IL2R alpha promoter constructs", "start": 6, "end": 44}, {"text": "kappa B enhancer", "start": 180, "end": 196}, {"text": "IL2R alpha gene", "start": 234, "end": 249}]}}, "schema": []}
{"input": "Palindromic rheumatism", "output": {"entities": {}}, "schema": []}
{"input": "Forty patients, divided according to their initial total gastrointestinal transit times and presenting symptoms, were treated with cimetropium bromide 50 mg t. d. s. or placebo for 1 month according to a double-blind, parallel group design.", "output": {"entities": {}}, "schema": []}
{"input": "An immunologically related protein was detected in ribosome and membrane fractions of mitochondria from Saccharomyces cerevisiae.", "output": {"entities": {}}, "schema": []}
{"input": "Mapping of RNA-temperature-sensitive mutants of Sindbis virus: complementation group F mutants have lesions in nsP4.", "output": {"entities": {"gene": [{"text": "temperature-sensitive mutants of Sindbis virus: complementation group F mutants", "start": 15, "end": 94}, {"text": "nsP4", "start": 111, "end": 115}]}}, "schema": []}
{"input": "The effect of the thromboxane A2 (TXA2)/prostaglandin endoperoxide receptor antagonist, SQ 29, 548 on pacing-induced ischemia was determined in anesthetized open-chest dogs.", "output": {"entities": {"gene": [{"text": "thromboxane A2 (TXA2)/prostaglandin endoperoxide receptor", "start": 18, "end": 75}]}}, "schema": []}
{"input": "The recovery index (T25-T75) after the infusion stopped was similar in patients who received mivacurium and those who received suxamethonium.", "output": {"entities": {}}, "schema": []}
{"input": "The sign of Leser-Trelat: does it exist? The sign of Leser-Trelat is usually regarded as a reliable cutaneous marker of internal malignancy.", "output": {"entities": {}}, "schema": []}
{"input": "Three missense mutants in subunit a of the Escherichia coli F1F0-ATPase were isolated and characterized after hydroxylamine mutagenesis of a plasmid carrying the uncB (subunit a) gene.", "output": {"entities": {"gene": [{"text": "Escherichia coli F1F0-ATPase", "start": 43, "end": 71}, {"text": "uncB (subunit a) gene", "start": 162, "end": 183}]}}, "schema": []}
{"input": "Moreover, exons 2a and 2b share the same 5' sequence but differ from each other by the use of two distinct donor splice sites 171 bp apart in the gene.", "output": {"entities": {}}, "schema": []}
{"input": "S1 nuclease analysis of RNA prepared after transfection of these HIV constructs into HeLa cells infected with wild-type adenovirus indicated that the enhancer, SP1, TATA, and a portion of the transactivation-responsive element were each required for complete E1A/E1B-mediated activation of the HIV LTR.", "output": {"entities": {"gene": [{"text": "S1 nuclease", "start": 0, "end": 11}, {"text": "SP1", "start": 160, "end": 163}, {"text": "E1A", "start": 259, "end": 262}, {"text": "E1B", "start": 263, "end": 266}, {"text": "HIV LTR", "start": 294, "end": 301}]}}, "schema": []}
{"input": "In supine position, plasma ANP levels ranged from 12 pg/ml to 51. 5 pg/ml, with an average level of 35. 3 +/-11. 5 pg/ml.", "output": {"entities": {"gene": [{"text": "ANP", "start": 27, "end": 30}]}}, "schema": []}
{"input": "The overall prevalence of HBV markers was higher among staff members than in the blood donors of our area.", "output": {"entities": {}}, "schema": []}
{"input": "Quantitative predictions are confirmed for the positive responses, but not for the negatives, suggesting that the SSTS model is incorrect.", "output": {"entities": {}}, "schema": []}
{"input": "Plasma concentrations of ANF (pANF), aldosterone (PAC) and renin (PRC) were measured daily, as were hemodynamic parameters.", "output": {"entities": {"gene": [{"text": "ANF", "start": 25, "end": 28}, {"text": "pANF", "start": 30, "end": 34}, {"text": "renin", "start": 59, "end": 64}, {"text": "PRC", "start": 66, "end": 69}]}}, "schema": []}
{"input": "The adenovirus E1A gene encodes a protein that transcriptionally activates viral early genes.", "output": {"entities": {"gene": [{"text": "adenovirus E1A gene", "start": 4, "end": 23}, {"text": "viral early genes", "start": 75, "end": 92}]}}, "schema": []}
{"input": "Administration of dexamethasone was associated with progressive rises in plasma 17 alpha OH progesterone, 11 beta-desoxycortisol, DHEA sulphate, androstenedione and testosterone, together with increased urinary excretion of androsterone, 11 beta OH androsterone, etiocholanolone, DHEA, and 16 alpha OH DHEA.", "output": {"entities": {}}, "schema": []}
{"input": "RNA transcripts that hybridize to the introduced foreign gene have been identified.", "output": {"entities": {}}, "schema": []}
{"input": "In HeLa cells, it activated transcription from the herpes simplex virus type 1 thymidine kinase promoter linked to the chloramphenicol acetyltransferase gene when located in inverted orientation upstream of the thymidine kinase promoter or downstream of the chloramphenicol acetyltransferase gene coding sequence.", "output": {"entities": {"gene": [{"text": "herpes simplex virus type 1 thymidine kinase promoter", "start": 51, "end": 104}, {"text": "chloramphenicol acetyltransferase gene", "start": 119, "end": 157}, {"text": "thymidine kinase promoter", "start": 211, "end": 236}, {"text": "chloramphenicol acetyltransferase gene coding sequence", "start": 258, "end": 312}]}}, "schema": []}
{"input": "At the basal unstimulated condition, Ren1d 5' flanking sequence in the sense orientation inhibited basal CAT expression from the TK promoter of pUTKAT1, whereas the same sequence in the antisense orientation did not.", "output": {"entities": {"gene": [{"text": "Ren1d 5' flanking sequence", "start": 37, "end": 63}, {"text": "CAT", "start": 105, "end": 108}, {"text": "TK promoter", "start": 129, "end": 140}]}}, "schema": []}
{"input": "None were restricted from clinical duties, were given varicella-zoster immune globulin, or developed disease.", "output": {"entities": {"gene": [{"text": "varicella-zoster immune globulin", "start": 54, "end": 86}]}}, "schema": []}
{"input": "In the formalin test, however, naloxone attenuated morphine analgesia at the lower doses (0. 1 and 0. 3 mg/kg) and potentiated morphine analgesia at the highest dose (10 mg/kg).", "output": {"entities": {}}, "schema": []}
{"input": "We have isolated cDNA clones from rat brain and human liver encoding a putative isoform of the Na, K-ATPase beta subunit.", "output": {"entities": {"gene": [{"text": "Na, K-ATPase beta subunit", "start": 95, "end": 120}]}}, "schema": []}
{"input": "We have determined that several E1 mutants mapping in both the M and R regions and a single mutant of the upstream regulatory region have a higher transforming activity on mouse C127 cells than the wild-type genome does.", "output": {"entities": {"gene": [{"text": "E1 mutants", "start": 32, "end": 42}]}}, "schema": []}
{"input": "UbiA is also unique among known polyubiquitin genes in containing four cis-spliced introns within its coding sequence.", "output": {"entities": {"gene": [{"text": "UbiA", "start": 0, "end": 4}, {"text": "polyubiquitin genes", "start": 32, "end": 51}]}}, "schema": []}
{"input": "That of the T2 gene contains numerous potential sites for binding the mammalian transcription factor SP1, but no TATA or CCAAT sequences are evident near to its 5' end, although these latter features are associated with the human T1 gene.", "output": {"entities": {"gene": [{"text": "T2 gene", "start": 12, "end": 19}, {"text": "mammalian transcription factor SP1", "start": 70, "end": 104}, {"text": "human T1 gene", "start": 224, "end": 237}]}}, "schema": []}
{"input": "Radiation therapy was effective in controlling symptomatic metastasis in all three patients.", "output": {"entities": {}}, "schema": []}
{"input": "These results indicate that patients who undergo postoperative irradiation for low grade spinal astrocytomas and localized spinal ependymomas achieve excellent survival.", "output": {"entities": {}}, "schema": []}
{"input": "The methylation of nuclear and chloroplast DNAs has been examined in relation to the known differential expression of C4 photosynthesis genes in the bundle sheath and mesophyll cells of etiolated, greening, and fully green maize leaves.", "output": {"entities": {"gene": [{"text": "C4 photosynthesis genes", "start": 118, "end": 141}]}}, "schema": []}
{"input": "S1 nuclease analysis of RNA from chemically induced B95-8 cells and from Vero cells cotransfected with NotI repeat promoter-CAT and Z showed that Z transactivation increased the level of correctly initiated, stable RNA transcripts.", "output": {"entities": {"gene": [{"text": "S1 nuclease", "start": 0, "end": 11}, {"text": "NotI repeat promoter", "start": 103, "end": 123}, {"text": "CAT", "start": 124, "end": 127}, {"text": "Z", "start": 132, "end": 133}, {"text": "Z", "start": 146, "end": 147}]}}, "schema": []}
{"input": "Analysis of the DNA from 15 cases of sporadic and familial Wilms' tumor did not reveal any changes, indicating that the translocation breakpoint does not reside in this gene.", "output": {"entities": {}}, "schema": []}
{"input": "We also provide evidence that neither the lambda O and P initiators nor the E. coli DnaJ and DnaK heat shock proteins play a direct role in the propagation of lambda replication forks in vitro.", "output": {"entities": {"gene": [{"text": "lambda O", "start": 42, "end": 50}, {"text": "P initiators", "start": 55, "end": 67}, {"text": "E. coli DnaJ", "start": 76, "end": 88}, {"text": "DnaK", "start": 93, "end": 97}]}}, "schema": []}
{"input": "Synthetic oligonucleotides representing the 19 bp repeat unit strongly reduced the activity of the IE1/2 enhancer/promoter in cotransfection assays after transient expression.", "output": {"entities": {"gene": [{"text": "IE1/2 enhancer/promoter", "start": 99, "end": 122}]}}, "schema": []}
{"input": "Effects of nitrogen (PN2: 5 and 14 MPa) and helium (PHe: 13 and 14 MPa) were also tested.", "output": {"entities": {}}, "schema": []}
{"input": "The mustard chloroplast gene rps16 is split by an 887 bp group II (or III) intron.", "output": {"entities": {"gene": [{"text": "mustard chloroplast gene rps16", "start": 4, "end": 34}]}}, "schema": []}
{"input": "Antibodies raised to the expressed NS3 by immunization of mice detected both NS3 and NS3A in BTV-10-infected BHK cells but not in purified BTV-10 virus particles.", "output": {"entities": {"gene": [{"text": "NS3", "start": 35, "end": 38}, {"text": "NS3", "start": 77, "end": 80}, {"text": "NS3A", "start": 85, "end": 89}]}}, "schema": []}
{"input": "Similarly, supraventricular tachycaydia following resuscitative efforts appeared to be associated with a negative outcome.", "output": {"entities": {}}, "schema": []}
{"input": "The negative calcium balance with hyperparathyroidemia occurred after continuous oral administration of Cd and developed via increased urinary excretion of calcium.", "output": {"entities": {}}, "schema": []}
{"input": "Clone 4c (2681 bp) had a coding region identical to that of clone 22c but it included a putative intron of 959 bp.", "output": {"entities": {}}, "schema": []}
{"input": "The application of ISH and IHC did not change significantly the routine histologic classification of pneumonias into CMV-IP and IIP.", "output": {"entities": {}}, "schema": []}
{"input": "Validity of immunohistology and in situ hybridization in the differential diagnosis of cytomegalovirus pneumonia and idiopathic interstitial pneumonia after allogenic bone marrow transplantation", "output": {"entities": {}}, "schema": []}
{"input": "The unique nature and arrangement of the ANT1 transcriptional control elements may account for this differential expression.", "output": {"entities": {"gene": [{"text": "ANT1 transcriptional control elements", "start": 41, "end": 78}]}}, "schema": []}
{"input": "The Bacillus subtilis phage phi 105 repressor, a lambda repressor-like transcriptional regulatory protein, was overproduced in Escherichia coli and purified to near homogeneity in order to examine its in vitro DNA-binding properties.", "output": {"entities": {"gene": [{"text": "Bacillus subtilis phage phi 105 repressor", "start": 4, "end": 45}, {"text": "lambda repressor", "start": 49, "end": 65}]}}, "schema": []}
{"input": "In consequence, the gpI derived from cells infected with mO74 showed antigenic characteristics similar to those of gpI from VZV-infected cells as determined from the immunoprecipitation pattern, although the molecular weight of each polypeptide was different, and antibody produced in rabbits infected with recombinant virus had a high neutralizing activity, when the reaction was performed with complement.", "output": {"entities": {"gene": [{"text": "gpI", "start": 20, "end": 23}, {"text": "gpI", "start": 115, "end": 118}]}}, "schema": []}
{"input": "However, bilateral diffuse pulmonary infiltrations developed 21 days later.", "output": {"entities": {}}, "schema": []}
{"input": "Grossly, the incidence of a type IIc carcinoma was 46. 5% and that of a IIc + III type was 20. 5%, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "VP5, which encodes the major capsid protein, each fused to the chloramphenicol acetyltransferase gene.", "output": {"entities": {"gene": [{"text": "VP5", "start": 0, "end": 3}, {"text": "major capsid protein", "start": 23, "end": 43}, {"text": "chloramphenicol acetyltransferase gene", "start": 63, "end": 101}]}}, "schema": []}
{"input": "Of 202 initially seronegative caretakers (observed for an average of 305 days per woman), 19 seroconverted, for an annual seroconversion rate of 11 percent.", "output": {"entities": {}}, "schema": []}
{"input": "First, a pet54:: LEU2 cytoductant bearing the' short' mitochondrial genome that lacks both COX1 introns aI5 alpha and aI5 beta is defective only in COX3 gene expression and not in COX1 mRNA splicing or mRNA translation.", "output": {"entities": {"gene": [{"text": "pet54", "start": 9, "end": 14}, {"text": "LEU2", "start": 17, "end": 21}, {"text": "COX1 introns aI5 alpha", "start": 91, "end": 113}, {"text": "aI5 beta", "start": 118, "end": 126}, {"text": "COX3 gene", "start": 148, "end": 157}, {"text": "COX1 mRNA", "start": 180, "end": 189}]}}, "schema": []}
{"input": "Insert2 contains repetitive non-Ig-related sequences and a small Ig-related sequence.", "output": {"entities": {"gene": [{"text": "Ig", "start": 32, "end": 34}, {"text": "small Ig-related sequence", "start": 59, "end": 84}]}}, "schema": []}
{"input": "Since considerable variations in length and primary sequence in the CDR3 (complementarity determining region) peptides of all the H-chains are evident, conservation of the D-region structure does not appear to be necessary for effective hapten binding.", "output": {"entities": {"gene": [{"text": "CDR3", "start": 68, "end": 72}, {"text": "complementarity determining region", "start": 74, "end": 108}, {"text": "H-chains", "start": 130, "end": 138}, {"text": "D-region", "start": 172, "end": 180}]}}, "schema": []}
{"input": "Tyrosine kinase oncogenes abrogate interleukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc: conditional regulation of c-myc transcription by temperature-sensitive v-abl.", "output": {"entities": {"gene": [{"text": "Tyrosine kinase", "start": 0, "end": 15}, {"text": "interleukin-3", "start": 35, "end": 48}, {"text": "c-myc", "start": 121, "end": 126}, {"text": "c-myc", "start": 154, "end": 159}, {"text": "v-abl", "start": 199, "end": 204}]}}, "schema": []}
{"input": "The DNA helix at the tandemly repeated, 13mer sequence is thermodynamically unstable, as evidenced by hypersensitivity to single-strand-specific nuclease in a negatively supercoiled plasmid, and demonstrated by stable DNA unwinding seen after two-dimensional gel electrophoresis of topoisomers.", "output": {"entities": {"gene": [{"text": "single-strand-specific nuclease", "start": 122, "end": 153}]}}, "schema": []}
{"input": "There has been similar improvement in treating ampullary and periampullary cancer, gallbladder cancer, or extrahepatic bile duct cancer.", "output": {"entities": {}}, "schema": []}
{"input": "Beta-endorphin, ACTH and cortisol secretion were measured in twelve healthy adult males after nasal spray administration 200 IU salmon calcitonin.", "output": {"entities": {"gene": [{"text": "Beta-endorphin", "start": 0, "end": 14}, {"text": "ACTH", "start": 16, "end": 20}, {"text": "salmon calcitonin", "start": 128, "end": 145}]}}, "schema": []}
{"input": "The data indicate that calcitonin induced a beta-endorphin increase independent of enhanced corticotrophin-cortisol release.", "output": {"entities": {"gene": [{"text": "calcitonin", "start": 23, "end": 33}, {"text": "beta-endorphin", "start": 44, "end": 58}, {"text": "corticotrophin", "start": 92, "end": 106}]}}, "schema": []}
{"input": "Other hemostatic values evaluated were activated partial thromboplastin times, prothrombin times, thrombin times, fibrinogen, platelet counts, and fibrin/fibrinogen degradation products.", "output": {"entities": {"gene": [{"text": "thromboplastin", "start": 57, "end": 71}, {"text": "prothrombin", "start": 79, "end": 90}, {"text": "thrombin", "start": 98, "end": 106}, {"text": "fibrinogen", "start": 114, "end": 124}, {"text": "fibrin", "start": 147, "end": 153}, {"text": "fibrinogen", "start": 154, "end": 164}]}}, "schema": []}
{"input": "Rare neurogenic tumor with metastasis to mouth, jaw and face regions", "output": {"entities": {}}, "schema": []}
{"input": "We have designated the protein \" cellular NBP \" (CNBP).", "output": {"entities": {"gene": [{"text": "\" cellular NBP \"", "start": 31, "end": 47}, {"text": "CNBP", "start": 49, "end": 53}]}}, "schema": []}
{"input": "Responsiveness to beta-2 agonist therapy was retained with both agents (p less than 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "Drug use in trauma victims.", "output": {"entities": {}}, "schema": []}
{"input": "A critical heart rate and/or appropriate sympathetic state was found to provoke all instances of reentrant or automatic atrial tachycardia and atypical junctional tachycardia.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast, the neu proto-oncogene did not show kinase activity or transforming properties when expressed at similar levels in NIH 3T3 cells. (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {"gene": [{"text": "neu proto-oncogene", "start": 17, "end": 35}]}}, "schema": []}
{"input": "The 65-bp sequence contains the octameric cAMP-responsive enhancer (CRE) TGACGTCA (nucleotides-48 to-41).", "output": {"entities": {}}, "schema": []}
{"input": "Somatostatin gene expression in pancreatic islet cells is directed by cell-specific DNA control elements and DNA-binding proteins.", "output": {"entities": {"gene": [{"text": "Somatostatin gene", "start": 0, "end": 17}]}}, "schema": []}
{"input": "In contrast, the full mu-opioid agonists fentanyl, morphine, I-methadone and levorphanol produced 50% fentanyl-appropriate responding at doses only 1. 3 to 10. 9 times smaller than those required to decrease response rates by 50%.", "output": {"entities": {}}, "schema": []}
{"input": "After overtraining on the original discrimination, the controls showed the normal difficulty in learning the first reversal.", "output": {"entities": {}}, "schema": []}
{"input": "Isolation and characterization of a cDNA encoding a putative cytokine which is induced by stimulation via the CD2 structure on human T lymphocytes.", "output": {"entities": {"gene": [{"text": "CD2 structure", "start": 110, "end": 123}]}}, "schema": []}
{"input": "After termination of medication the animals were kindled electrically in the nucleus amygdala.", "output": {"entities": {}}, "schema": []}
{"input": "Haploid cells of mating type A of the basidiomycetous yeast Rhodosporidium toruloides secrete a mating pheromone, rhodotorucine A, which is an undecapeptide containing S-farnesyl cysteine at its carboxy terminus.", "output": {"entities": {"gene": [{"text": "rhodotorucine A", "start": 114, "end": 129}]}}, "schema": []}
{"input": "Tumour necrosis factor and adult respiratory distress syndrome.", "output": {"entities": {"gene": [{"text": "Tumour necrosis factor", "start": 0, "end": 22}]}}, "schema": []}
{"input": "Monitoring of rheumatoid arthritis.", "output": {"entities": {}}, "schema": []}
{"input": "The decrease in left ventricular (LV) stroke volume during positive end-expiratory pressure (PEEP) has been attributed to reduced LV filling and a decreased contractile state.", "output": {"entities": {}}, "schema": []}
{"input": "An experiment on the return-of-fear (ROF) was carried out on 40 snake-or spider-phobic subjects in order to determine whether an arousing event that occurs shortly before retest influences the magnitude of the ROF.", "output": {"entities": {}}, "schema": []}
{"input": "Evolutionary conservation of homeodomain-binding sites and other sequences upstream and within the major transcription unit of the Drosophila segmentation gene engrailed.", "output": {"entities": {"gene": [{"text": "homeodomain", "start": 29, "end": 40}, {"text": "Drosophila segmentation gene engrailed", "start": 131, "end": 169}]}}, "schema": []}
{"input": "To assess the functional importance of these NBS in the overall drug resistance phenotype conferred by mdr1, we introduced amino acid substitutions in the core consensus sequence for nucleotide binding, GXGKST.", "output": {"entities": {"gene": [{"text": "mdr1", "start": 103, "end": 107}]}}, "schema": []}
{"input": "When the first twitch of TOF spontaneously recovered to 10% of control value, neostigmine was injected (40 micrograms/kg in adults, 30 micrograms/kg in infants and children).", "output": {"entities": {}}, "schema": []}
{"input": "No significant differences were found in relation to Type A behaviour and beta-adrenoceptor blockade.", "output": {"entities": {"gene": [{"text": "beta-adrenoceptor", "start": 74, "end": 91}]}}, "schema": []}
{"input": "Selection of the 22 items of the Clinical Institute Withdrawal Assessment-Benzodiazepines (CIWA-B) was based on statistically significant differences between baseline and critical withdrawal periods in high-dose subjects and between symptoms associated with placebo and diazepam in low-dose subjects, using contingency tables and logistic regression analysis.", "output": {"entities": {}}, "schema": []}
{"input": "Northern blot analysis revealed multiple oIGF-I transcripts in a broad band at 800-1, 100 nucleotides and other transcripts of higher molecular weight in liver.", "output": {"entities": {"gene": [{"text": "oIGF-I transcripts", "start": 41, "end": 59}]}}, "schema": []}
{"input": "Materials science studies on the soldering of different orthodontic wires", "output": {"entities": {}}, "schema": []}
{"input": "The latency time for the lactate concentration to reach the top values was reduced by aerobic training (T2).", "output": {"entities": {}}, "schema": []}
{"input": "In patients resistant to VAD, high-dose therapies with intravenous melphalan, a CBV combination (cyclophosphamide-BCNU-VP-16) or an EDAP regimen (VP-16-platinum) produced responses in about 40% of patients.", "output": {"entities": {}}, "schema": []}
{"input": "The avian cellular homolog of the oncogene jun.", "output": {"entities": {"gene": [{"text": "oncogene jun", "start": 34, "end": 46}]}}, "schema": []}
{"input": "High ATP/GTP ratios promoted initiation of RNA primer synthesis at 3'-dCTTT sites, whereas low ATP/GTP ratios promoted initiation at 3'-dCCC sites.", "output": {"entities": {}}, "schema": []}
{"input": "After hepatitis B vaccine immunization, serum antibody response was of primary type in 33 cases with anti-HBs less than 2. 1 S/N (S/N Ratio Unit) at T0, the anti-HBs positive rate was 39. 4%, 84. 8%, 96. 7% and 96. 7% in T1, T2, T0 and T12 respectively.", "output": {"entities": {"gene": [{"text": "anti-HBs", "start": 101, "end": 109}, {"text": "anti-HBs", "start": 157, "end": 165}]}}, "schema": []}
{"input": "The experimental design incorporated a multiple regression model, sequential treatments and a proportional end point (95%) for protection time.", "output": {"entities": {}}, "schema": []}
{"input": "Interspecific complementation tests showed that the P7 proteins are unable to complement P1 parA or parB mutants, and the P1 proteins fail to complement the P7 mutations.", "output": {"entities": {"gene": [{"text": "P7 proteins", "start": 52, "end": 63}, {"text": "P1 parA", "start": 89, "end": 96}, {"text": "parB mutants", "start": 100, "end": 112}, {"text": "P1 proteins", "start": 122, "end": 133}, {"text": "P7 mutations", "start": 157, "end": 169}]}}, "schema": []}
{"input": "GN101, YC819-9, and SB3.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of the inferred 1, 859-residue ama-1 product showed considerable identity with the largest subunit of RNAP II from other organisms, including the presence of a zinc finger motif near the amino terminus, and a carboxyl-terminal domain of 42 tandemly reiterated heptamers with the consensus Tyr Ser Pro Thr Ser Pro Ser.", "output": {"entities": {"gene": [{"text": "1, 859-residue ama-1 product", "start": 25, "end": 53}, {"text": "RNAP II", "start": 111, "end": 118}]}}, "schema": []}
{"input": "5.", "output": {"entities": {}}, "schema": []}
{"input": "None of the measured parameters (heart contents of neutral lipids, total phospholipids, phosphatidylcholine, phosphatidylethanolamine, diphosphatidylglycerol, sphingomyelin and fatty acid composition of each phospholipid class) appeared to be related with the grading of the lesions.", "output": {"entities": {}}, "schema": []}
{"input": "Of 165 women with non-malignant diagnoses 26 (16%) had CA 125 levels in excess of 35 U/ml and 8 (5%) greater than 65 U/ml.", "output": {"entities": {"gene": [{"text": "CA 125", "start": 55, "end": 61}]}}, "schema": []}
{"input": "We conclude that at steady state the timing of a light meal is unlikely to alter in any clinically important manner the pharmacokinetics of nifedipine released from' biphasic' tablets.", "output": {"entities": {}}, "schema": []}
{"input": "The GALT-primed calves had increased serum IgG, lavage IgG and IgA and increased LNA titers in both lavage fluids and serum following the SC dose of killed bacteria.", "output": {"entities": {"gene": [{"text": "IgG", "start": 43, "end": 46}, {"text": "IgG", "start": 55, "end": 58}, {"text": "IgA", "start": 63, "end": 66}, {"text": "LNA", "start": 81, "end": 84}]}}, "schema": []}
{"input": "Recent investigations have shown that Grenz rays can suppress the allergic contact dermatitis reaction completely and that Langerhans cells, identified by OKT6 antibodies and electron microscopy, disappear from the epidermis at the same time.", "output": {"entities": {"gene": [{"text": "OKT6 antibodies", "start": 155, "end": 170}]}}, "schema": []}
{"input": "The elements responsible for glucocorticoid stimulation of ADH gene transcription appear to reside outside of this region.", "output": {"entities": {"gene": [{"text": "ADH gene", "start": 59, "end": 67}]}}, "schema": []}
{"input": "1.", "output": {"entities": {}}, "schema": []}
{"input": "The present studies compare the biochemical characteristics, Kanagawa hemolysin reactions, and plasmid profiles of 13 patient and 221 environmental isolates of the organism.", "output": {"entities": {"gene": [{"text": "hemolysin", "start": 70, "end": 79}]}}, "schema": []}
{"input": "High values of both retinol and beta-carotene were found in full fat cheeses and whipping cream: from 179. 0 (cheese, Edam-type) to 318. 7 micrograms/100 g (whipping cream) and from 86. 7 (cheese, Edam-type) to 186. 5 micrograms/100 g (whipping cream) for all-trans retinol and total beta-carotene, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "COGLAB includes measures of preattentional, attentional, conceptual, and psychomotor performance.", "output": {"entities": {}}, "schema": []}
{"input": "With respect to effective diffusivity of platelets (De) and the surface reactivity constant (K), less significant differences were found among artificial materials.", "output": {"entities": {}}, "schema": []}
{"input": "The two most recent patients (35 and 132 days) received only oral dipyridamole (75 mg X 3/day) and aspirin (80 mg/day) after the early recovery period (four-six days), resulting in normal prothrombin and partial thromboplastin times.", "output": {"entities": {"gene": [{"text": "prothrombin", "start": 188, "end": 199}, {"text": "thromboplastin", "start": 212, "end": 226}]}}, "schema": []}
{"input": "Middle-latency auditory evoked potentials (MAEPs) were recorded in controls and patients with focal lesions in dorsolateral prefrontal cortex.", "output": {"entities": {}}, "schema": []}
{"input": "Specifically, they were performed to determine whether detection of envelope phase disparity was consistent with processing within a single channel in which the AM tones were simply added.", "output": {"entities": {}}, "schema": []}
{"input": "Gel retardation assays combined with DNase I footprinting and diethyl pyrocarbonate interference showed that a nuclear factor from differentiated C2 myotubes and BC3H1 myocytes recognized a conserved A + T-rich sequence within the peripheral activating region.", "output": {"entities": {"gene": [{"text": "DNase I", "start": 37, "end": 44}]}}, "schema": []}
{"input": "Such transgenic plants should enable not only the mutational analysis of sequence elements within the replication origin region, but also the construction of a new generation of vectors for gene amplification in plants, based on a minimal virus replicon.", "output": {"entities": {}}, "schema": []}
{"input": "Ventral rhinotomy is no more difficult than dorsal rhinotomy, has less patient morbidity and fewer postoperative complications, and is more cosmetically acceptable.", "output": {"entities": {}}, "schema": []}
{"input": "Four full-thickness skin incisions were made in the back of 10 female pigs that treated twice a day for 14 days with 2 ml of epidermal growth factor (300 ng/ml) or 2 ml of Ringer' s lactate solution in a single-blind, randomized fashion.", "output": {"entities": {"gene": [{"text": "epidermal growth factor", "start": 125, "end": 148}]}}, "schema": []}
{"input": "During challenge, rebiopsy was done when reticulin antibodies turned positive (mean 0. 6 years, range 0. 2-2. 0) or at the end of the two year study.", "output": {"entities": {"gene": [{"text": "reticulin antibodies", "start": 41, "end": 61}]}}, "schema": []}
{"input": "The effect of iron intake on 59Fe absorption throughout pregnancy, and on maternal and fetal Fe status towards the end of pregnancy, was investigated in rats.", "output": {"entities": {}}, "schema": []}
{"input": "The deduced protein sequence is characterized by a putative 16-residue amino-terminal signal peptide that is cleaved, resulting in a 239-residue polypeptide.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of the rate constants indicated that the isomerization rate k12 was approximately equal to the apparent degradation rate of the delta 3 ester kdeg, and slower than the hydrolysis rate of the delta 2 ester k24.", "output": {"entities": {}}, "schema": []}
{"input": "A protocol is elaborated for the preparation and characterization of a quality control material (QCM) containing intrinsic concentration of cadmium (Cd) (0. 8 microgram/L) and lead (Pb) (13. 4 micrograms/dL) from bovine blood and an elevated QCM containing Cd (5. 0 micrograms/L), mercury (Hg) (11. 2 micrograms/L), and Pb (34. 5 micrograms/dL) from bovine blood spiked with aqueous spiking-solutions prepared with salts of Cd, Hg, and Pb.", "output": {"entities": {}}, "schema": []}
{"input": "Reagent strips are frequently used in the practice of laboratory medicine as well as outside the professional laboratories.", "output": {"entities": {}}, "schema": []}
{"input": "Precipitating antibodies for Thermophilic actinomycetes and M. f. were negative.", "output": {"entities": {}}, "schema": []}
{"input": "LON-72 (34 isolates), LON-73 (1), LON-71 (2) and LON-10 (2) were found at altitudes around 2000 m, 3 of them in a single village.", "output": {"entities": {}}, "schema": []}
{"input": "Animal experimental and clinical applications of plates, screws and spinal segmental replacement implants made of this composite material have shown good results so far.", "output": {"entities": {}}, "schema": []}
{"input": "Significance of delta-aminolevulinic acid analysis in clinical tests", "output": {"entities": {}}, "schema": []}
{"input": "No changes were evident in the FR-task performance of controls that received daily saline injections.", "output": {"entities": {}}, "schema": []}
{"input": "Although the fertility decline in the black population in the Mississippi Delta between the late 1870' s and early 1930' s closely paralleled that of the national black population, it rose much more dramatically in the 1940' s and 1950' s to almost 1880 levels.", "output": {"entities": {}}, "schema": []}
{"input": "According to their staining affinity for anti-T antibodies, the glandular tissue cells were classified as T-, T +, T + +, and T and the annual changes in the numbers of these cell populations, as well as in the volume occupied by the glandular tissue, were calculated.", "output": {"entities": {"gene": [{"text": "anti-T antibodies", "start": 41, "end": 58}, {"text": "T", "start": 106, "end": 107}, {"text": "T", "start": 110, "end": 111}, {"text": "T", "start": 115, "end": 116}, {"text": "T", "start": 126, "end": 127}]}}, "schema": []}
{"input": "Ampicillin (AMP) alone or with an aminoglycoside (AMI) was the treatment in 9 and 16 cases, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Alkoxymetgyl-3, 4-dimethylpyridinium chlorides were synthetized by reacting 3, 4-dimethylpyridine with chloromethyl alkyl ethers, while 1-ethyloxymethyl-3-alkylthiomethylimidazolium chlorides were obtained in reactions of 1-ethyloxymethylimidazol with chloromethyl alkyl sulfides.", "output": {"entities": {}}, "schema": []}
{"input": "We investigated the incidence of congenital color deficiency among Koreans by the use of H-R-R pseudoisochromatic plates.", "output": {"entities": {}}, "schema": []}
{"input": "Eighty patients presenting to HGGM with non-Hodgkin' s lymphomas between 1962 and 1986, were reviewed.", "output": {"entities": {}}, "schema": []}
{"input": "The relation between VE/VO2 and Q/VO2 showed a significant negative correlation (r =-0. 93, p less than 0. 01).", "output": {"entities": {}}, "schema": []}
{"input": "Retrograde filling consists in sealing endodontics system directly at the apical zone after surgical approach.", "output": {"entities": {}}, "schema": []}
{"input": "Collaborative study of Japanese Pharmacopoeia Heparin Sodium Reference Standard", "output": {"entities": {}}, "schema": []}
{"input": "Serological studies at the early relapse stage of this disease showed increased serum ANA, IgA and IgM level with normal IgG and decrease of C3 and C4.", "output": {"entities": {"gene": [{"text": "serum ANA", "start": 80, "end": 89}, {"text": "IgA", "start": 91, "end": 94}, {"text": "IgM", "start": 99, "end": 102}, {"text": "IgG", "start": 121, "end": 124}, {"text": "C3", "start": 141, "end": 143}, {"text": "C4", "start": 148, "end": 150}]}}, "schema": []}
{"input": "The maximum stress due to the hygroscopic examination of the composite was 0. 74 kg/mm2 at equilibrium of the water absorbed of the composite.", "output": {"entities": {}}, "schema": []}
{"input": "Ischemic heart disease evaluated by exercise stress thallium-201 myocardial scintigraphy: a comparison of SPECT and bull' s eye display", "output": {"entities": {}}, "schema": []}
{"input": "Sequence analysis of the 47-kilodalton major integral membrane immunogen of Treponema pallidum.", "output": {"entities": {"gene": [{"text": "47-kilodalton major integral membrane immunogen of Treponema pallidum", "start": 25, "end": 94}]}}, "schema": []}
{"input": "Potential consensus sequences for early and late regulatory elements were identified.", "output": {"entities": {}}, "schema": []}
{"input": "Construction of a RIP1 deletion strain and isolation of temperature-sensitive mutants.", "output": {"entities": {"gene": [{"text": "RIP1", "start": 18, "end": 22}]}}, "schema": []}
{"input": "These data suggest that hypocitraturia in type I renal tubular acidosis may be due to a defect in proximal tubule function.", "output": {"entities": {}}, "schema": []}
{"input": "Concomitant chronic lymphocytic leukemia, acute myeloid leukemia, and thrombosis with protein C deficiency.", "output": {"entities": {"gene": [{"text": "protein C", "start": 86, "end": 95}]}}, "schema": []}
{"input": "Vivid visual hallucinations without other psychopathology have been reported for several hundred years.", "output": {"entities": {}}, "schema": []}
{"input": "In the whole group, basal GH and somatomedin-C levels decreased from a mean (+/-standard error of the mean) of 52. 3 +/-12. 7 to 11. 1 +/-6. 3 ng/ml and from 7. 6 +/-0. 7 to 2. 5 +/-0. 5 U/ml, respectively.", "output": {"entities": {"gene": [{"text": "GH", "start": 26, "end": 28}, {"text": "somatomedin-C", "start": 33, "end": 46}]}}, "schema": []}
{"input": "Application of different criteria of cure revealed that 19 patients (66%) had basal GH levels below 5 ng/ml, 17 patients (59%) had normal somatomedin-C values, 16 patients (55%) had complete GH suppression (less than 1 ng/ml) during OGTT, and 13 patients (45%) met the above-mentioned criteria with disappearance of the paradoxical GH response to TRH/GnRH test.", "output": {"entities": {"gene": [{"text": "GH", "start": 84, "end": 86}, {"text": "somatomedin-C", "start": 138, "end": 151}, {"text": "GH", "start": 191, "end": 193}, {"text": "GH", "start": 332, "end": 334}, {"text": "TRH", "start": 347, "end": 350}, {"text": "GnRH", "start": 351, "end": 355}]}}, "schema": []}
{"input": "It suggests a sequence of surgical planning that can prevent them and also offers ways of dealing with the problems should they occur.", "output": {"entities": {}}, "schema": []}
{"input": "In Rat-1a cells the expression of human c-jun mRNA was associated with the ability to clone in soft agarose and form tumors in nude mice.", "output": {"entities": {"gene": [{"text": "human c-jun mRNA", "start": 34, "end": 50}]}}, "schema": []}
{"input": "Furthermore, formation of foci of transformed RECs by the c-jun/ras combination was augmented 3-fold by the tumor promoter phorbol 12-tetradecanoate 13-acetate.", "output": {"entities": {"gene": [{"text": "c-jun", "start": 58, "end": 63}, {"text": "ras", "start": 64, "end": 67}]}}, "schema": []}
{"input": "Platelet activating factor was given in six doses at 15 minute intervals and airway response measured as change in partial expiratory flow at 30% of vital capacity (Vp30).", "output": {"entities": {"gene": [{"text": "Platelet activating factor", "start": 0, "end": 26}]}}, "schema": []}
{"input": "There was no significant correlation between baseline PC40 methacholine and the maximal fall in Vp30 after either the first (12 micrograms) or the second dose (24 micrograms) of platelet activating factor.", "output": {"entities": {"gene": [{"text": "platelet activating factor", "start": 178, "end": 204}]}}, "schema": []}
{"input": "Both BG and IRI concentrations during the OGTT were the lowest in body builders, medium in controls, and the highest in obese men.", "output": {"entities": {"gene": [{"text": "IRI", "start": 12, "end": 15}]}}, "schema": []}
{"input": "Although it is well known that calcium channel blockers can influence contraction of vascular smooth muscle, there is less knowledge on its effect on excitation contraction coupling in the endocrine glands and more specifically on insulin and glucagon release.", "output": {"entities": {"gene": [{"text": "insulin", "start": 231, "end": 238}, {"text": "glucagon", "start": 243, "end": 251}]}}, "schema": []}
{"input": "Many studies have pointed out the possibility of \" masked \" organic factors in erectile impotence, detectable only by means of laboratory investigations: mild hypogonadism, hyperprolactinemia, occlusions selectively located at the site of the sexual arteries, venous incompetence, subclinical neuropathies.", "output": {"entities": {}}, "schema": []}
{"input": "The site-specific DNA inversion system Cin encoded by the bacteriophage P1 consists of a recombinase, two inverted crossing-over sites and a recombinational enhancer.", "output": {"entities": {"gene": [{"text": "Cin", "start": 39, "end": 42}, {"text": "recombinase", "start": 89, "end": 100}]}}, "schema": []}
{"input": "The terminator region supported termination of transcripts initiated by RNA polymerase I in vivo.", "output": {"entities": {"gene": [{"text": "RNA polymerase I", "start": 72, "end": 88}]}}, "schema": []}
{"input": "US-Doppler has recently gained attention as a noninvasive method for the functional evaluation of arteriovenous fistulas (FAV).", "output": {"entities": {}}, "schema": []}
{"input": "Doppler echo in evaluating arteriovenous fistulae for dialysis", "output": {"entities": {}}, "schema": []}
{"input": "Following the patients during a course of therapy with a selective vasodilator calcium antagonist, the beta-adrenergic reflex vasodilation became substantially attenuated but was preserved during a placebo course of therapy.", "output": {"entities": {}}, "schema": []}
{"input": "Of 110 previously untreated patients who had entered the study of protocol TCL821, 96 were evaluable.", "output": {"entities": {}}, "schema": []}
{"input": "There were 3/32 (9. 4 per cent) adverse reactions (ADRs), and one case each of nausea, dizziness and increased menstrual flow.", "output": {"entities": {}}, "schema": []}
{"input": "More mRNA corresponding to nagB and nagA is detected than that corresponding to the distal genes, nagC and nagD.", "output": {"entities": {"gene": [{"text": "nagB", "start": 27, "end": 31}, {"text": "nagA", "start": 36, "end": 40}, {"text": "nagC", "start": 98, "end": 102}, {"text": "nagD", "start": 107, "end": 111}]}}, "schema": []}
{"input": "Tumor necrosis factor (TNF) is reported to cause a shock syndrome similar to that produced by endotoxin (LPS).", "output": {"entities": {"gene": [{"text": "Tumor necrosis factor", "start": 0, "end": 21}, {"text": "TNF", "start": 23, "end": 26}]}}, "schema": []}
{"input": "The p34. 8 gene has a strong codon usage bias which is strikingly different from that of the polyhedrin gene.", "output": {"entities": {"gene": [{"text": "p34. 8 gene", "start": 4, "end": 15}, {"text": "polyhedrin gene", "start": 93, "end": 108}]}}, "schema": []}
{"input": "Of the single-stranded DNA transformants, 65% resulted from replacement of the resident met2 mutation by the exogenous wild-type allele.", "output": {"entities": {"gene": [{"text": "met2 mutation", "start": 88, "end": 101}]}}, "schema": []}
{"input": "The results strongly support the notion that the OBF1-binding sites and the OBF1 protein are important for normal ARS function as an origin of replication.", "output": {"entities": {"gene": [{"text": "OBF1-binding sites", "start": 49, "end": 67}, {"text": "OBF1 protein", "start": 76, "end": 88}]}}, "schema": []}
{"input": "On the basis of S1 nuclease protection analysis of RNA preparations from several mouse tissues, both dhfr and divergent genes showed similar levels of expression but did show some specificity in start site utilization.", "output": {"entities": {"gene": [{"text": "S1 nuclease", "start": 16, "end": 27}, {"text": "dhfr", "start": 101, "end": 105}]}}, "schema": []}
{"input": "Four out of 10 patients showed clinical improvement according to Ritchie-Index, pain score, ESR and CRP.", "output": {"entities": {"gene": [{"text": "CRP", "start": 100, "end": 103}]}}, "schema": []}
{"input": "62: 2491-2499, 1987).", "output": {"entities": {}}, "schema": []}
{"input": "Survival rates for the original treatment group were 84. 5% and 57. 6% at 12 and 21 months, respectively; for the delayed treatment group, 78. 8% and 64. 6% at 12 and 21 months, respectively, and 78. 8% and 47. 5% at 12 and 21 months, respectively, for 77 subjects with AIDS and 93. 0% and 71. 8%, respectively, for 50 subjects with AIDS-related complex in the original treatment group.", "output": {"entities": {}}, "schema": []}
{"input": "The products of genes ura10 and ura3 are proposed to participate in the channeling of orotidine monophosphate.", "output": {"entities": {"gene": [{"text": "ura10", "start": 22, "end": 27}, {"text": "ura3", "start": 32, "end": 36}]}}, "schema": []}
{"input": "After the application of RS 86, REM latency was shortened in all groups under investigation.", "output": {"entities": {}}, "schema": []}
{"input": "Hybridization analysis showed that the size of the mRNA is about 1. 4 kilobases.", "output": {"entities": {}}, "schema": []}
{"input": "Agranulocytosis treatment with rhGM-CSF", "output": {"entities": {}}, "schema": []}
{"input": "The R. meliloti nifH promoter but not the K. pneumoniae nifH promoter showed sigma 54-dependent methylation protection of guanine residues at-14,-25 and-26, the most conserved nucleotides characteristic of sigma 54-dependent promoters.", "output": {"entities": {"gene": [{"text": "R. meliloti nifH promoter", "start": 4, "end": 29}, {"text": "K. pneumoniae nifH promoter", "start": 42, "end": 69}, {"text": "sigma 54", "start": 77, "end": 85}, {"text": "sigma 54-dependent promoters", "start": 206, "end": 234}]}}, "schema": []}
{"input": "Major clinical symptoms of the disease were defined in this group of patients.", "output": {"entities": {}}, "schema": []}
{"input": "Routine clinical analysis revealed lower hematocrit and hemoglobin, and elevated BUN and alkaline phosphatase in the treated group.", "output": {"entities": {"gene": [{"text": "hemoglobin", "start": 56, "end": 66}, {"text": "alkaline phosphatase", "start": 89, "end": 109}]}}, "schema": []}
{"input": "To assess the health significance of the early renal changes after chronic exposure to cadmium, 23 workers removed from exposure because of the discovery of an increased urinary excretion of beta 2-microglobulin or retinol binding protein, or both, have been examined once a year for five years.", "output": {"entities": {"gene": [{"text": "beta 2-microglobulin", "start": 191, "end": 211}, {"text": "retinol binding protein", "start": 215, "end": 238}]}}, "schema": []}
{"input": "In order to study the structural and functional organization of the eukaryotic nucleolus, we have started to isolate and characterize nucleolar components of the yeast Saccharomyces cerevisiae.", "output": {"entities": {}}, "schema": []}
{"input": "A transcription factor exclusion assay was used to show that the PCF1 mutation affects two distinct stages in transcription: one prior to and one after stable complex formation; and that these effects are mediated by a component of the stable complex.", "output": {"entities": {"gene": [{"text": "PCF1 mutation", "start": 65, "end": 78}]}}, "schema": []}
{"input": "Psychiatry and the skin.", "output": {"entities": {}}, "schema": []}
{"input": "These adverse effects usually abate with time.", "output": {"entities": {}}, "schema": []}
{"input": "The cytosolic glutathione S-transferases (GSTs, EC 2. 5. 1. 18) are a superfamily of dimeric isoenzymes which catalyze the conjugation of electrophilic substrates with glutathione.", "output": {"entities": {"gene": [{"text": "glutathione S-transferases", "start": 14, "end": 40}, {"text": "GSTs", "start": 42, "end": 46}, {"text": "EC 2. 5. 1. 18", "start": 48, "end": 62}]}}, "schema": []}
{"input": "Furthermore, the 3'-untranslated regions of pmGT10 display a marked degree of homology to the 3' region of the rat Yb1 gene, while this region of pmGT2 displays marked homology to the corresponding region of the rat Yb2 gene.", "output": {"entities": {"gene": [{"text": "pmGT10", "start": 44, "end": 50}, {"text": "rat Yb1 gene", "start": 111, "end": 123}, {"text": "pmGT2", "start": 146, "end": 151}, {"text": "rat Yb2 gene", "start": 212, "end": 224}]}}, "schema": []}
{"input": "Model IV: primary abutments with the lateral incisor and the second molar as secondary abutments.", "output": {"entities": {}}, "schema": []}
{"input": "The incidence of fetal breathing movements (06. 00-10. 00 h) decreased with increasing gestational age while fetal arterial concentrations of plasma PGE increased significantly over the same period of gestation.", "output": {"entities": {}}, "schema": []}
{"input": "During the first 3 min of recovery, plasma potassium fell rapidly in spite of nearly unchanged blood acidosis and significantly decreasing bicarbonate concentration.", "output": {"entities": {}}, "schema": []}
{"input": "The present data also suggest that when compared to the systemic vascular bed, the pulmonary vascular bed is less responsive to bolus administration of ET-1.", "output": {"entities": {"gene": [{"text": "ET-1", "start": 152, "end": 156}]}}, "schema": []}
{"input": "In comparison with normal pregnant women and normal non-pregnant women, women with PIH showed an increase in heart rate, suggesting an increased peripheral sympathetic tone, and an initial derangement in renal function as shown by the increase in serum uric acid and reduction in sodium excretion and total and fractional calcium excretion at any given level of sodium excretion.", "output": {"entities": {}}, "schema": []}
{"input": "We have examined the role of two recombination-and repair-defective mutations, rad1 and rad52, on direct repeat recombination in transcriptionally active and inactive sequences.", "output": {"entities": {"gene": [{"text": "rad1", "start": 79, "end": 83}, {"text": "rad52", "start": 88, "end": 93}]}}, "schema": []}
{"input": "The encoded protein has a leader sequence of 27 amino acids.", "output": {"entities": {}}, "schema": []}
{"input": "On the other hand, knowledge of the epidemiology of Parkinson' s disease is necessary in creating etiological hypotheses, since only hypotheses consistent with the epidemiological profile deserve careful testing.", "output": {"entities": {}}, "schema": []}
{"input": "The stereoselectivity of drug action.", "output": {"entities": {}}, "schema": []}
{"input": "Scotchbond 2 showed the least dye penetration but not statistically less than the XR bond/Silus Plus combination.", "output": {"entities": {}}, "schema": []}
{"input": "A combination of cisplatin and 5-fluorouracil, both administered 4 days continuously as infusion, was assessed in advanced head and neck cancer.", "output": {"entities": {}}, "schema": []}
{"input": "Diagnosis of primary sclerosing cholangitis in a blood donor with elevated serum alanine aminotransferase.", "output": {"entities": {"gene": [{"text": "serum alanine aminotransferase", "start": 75, "end": 105}]}}, "schema": []}
{"input": "When statistically analyzed in various subgroupings, the obtained average sedimentation coefficients and polydispersity profiles supported the following conclusions: (a) loss of proteoglycan aggregation and sedimentability is confirmed to be a primary sign of cartilage matrix degradation; (b) higher S values for proteoglycans of the high weight (HW)-bearing areas and lower values for those of the low weight (LW)-bearing areas were a typical finding in normal cartilage samples; (c) inversion of this pattern was indicative of matrix degradation, suggesting that the HW regions are more affected than the LW-bearing areas; (d) the average S value distribution across cartilage thickness tended to resemble the corresponding proteoglycan content versus distance from articular surface; and (e) the deepest cartilage layer had, in most cases, the smallest amount of aggregates while the highest average sedimentability was observed at the middle zone of the normal samples.", "output": {"entities": {}}, "schema": []}
{"input": "End points measured were perioperative (30-day) myocardial infarction (MI) rate and death.", "output": {"entities": {}}, "schema": []}
{"input": "The predicted molecular weight of the polyprotein encoded by ORF1 is 33 kilodaltons (kDa).", "output": {"entities": {}}, "schema": []}
{"input": "Thus RV O2 demand fell when RC O2 supply was reduced, although a flow reserve was available.", "output": {"entities": {}}, "schema": []}
{"input": "An alternative method of UKM is proposed based on collecting a small fraction of spent dialysate flow for 3 consecutive dialyses.", "output": {"entities": {}}, "schema": []}
{"input": "Primer extension experiments indicated that the transcription initiation site mapped to a position on gene IV that was analogous to that reported for the structurally similar P-450e gene.", "output": {"entities": {"gene": [{"text": "gene IV", "start": 102, "end": 109}, {"text": "P-450e gene", "start": 175, "end": 186}]}}, "schema": []}
{"input": "Significantly, the polymerase chain reaction results demonstrated that gene IV transcripts were associated with hepatic polysome fractions, indicating their active utilization in this tissue.", "output": {"entities": {"gene": [{"text": "gene IV transcripts", "start": 71, "end": 90}]}}, "schema": []}
{"input": "Validation of the survey of work styles: a profile measure of the type A behaviour pattern.", "output": {"entities": {}}, "schema": []}
{"input": "Only one ADR was related definitely to ciprofloxacin therapy.", "output": {"entities": {}}, "schema": []}
{"input": "HIV infectiousness and the AIDS epidemic.", "output": {"entities": {}}, "schema": []}
{"input": "From day 30 after turnout, the PFB-group had significantly lower serum pepsinogen levels, which reflects the low degree of abomasal damage in these animals.", "output": {"entities": {"gene": [{"text": "serum pepsinogen", "start": 65, "end": 81}]}}, "schema": []}
{"input": "The corresponding inhibition of acid phosphatase activity in control male and female guinea pigs was 15. 91% and 20. 33% respectively.", "output": {"entities": {"gene": [{"text": "acid phosphatase", "start": 32, "end": 48}]}}, "schema": []}
{"input": "Its clinical and histopathologic characteristics.", "output": {"entities": {}}, "schema": []}
{"input": "Normocapnic (PACO2 = 40 mm Hg) ventilatory drive increased significantly (p less than 0. 05) in six subjects (Type 1 response) and decreased substantially in the others (Type 2 response); with hypercapnia, the changes in drive were attenuated in both groups.", "output": {"entities": {}}, "schema": []}
{"input": "Fundus changes in (type II) mesangiocapillary glomerulonephritis simulating drusen: a histopathological report.", "output": {"entities": {}}, "schema": []}
{"input": "Chronic dose effects of methyl parathion on nuthatches: cholinesterase and ptilochronology.", "output": {"entities": {"gene": [{"text": "cholinesterase", "start": 56, "end": 70}]}}, "schema": []}
{"input": "Allelic variation in HLA-B and HLA-C sequences and the evolution of the HLA-B alleles.", "output": {"entities": {"gene": [{"text": "HLA-B", "start": 21, "end": 26}, {"text": "HLA-C sequences", "start": 31, "end": 46}, {"text": "HLA-B alleles", "start": 72, "end": 85}]}}, "schema": []}
{"input": "A method for determining optimal development conditions by summary oxygen consumption", "output": {"entities": {}}, "schema": []}
{"input": "Men were more positive about their physical fitness than women.", "output": {"entities": {}}, "schema": []}
{"input": "Handgrip dynamometry was also carried out in 249 of the patients.", "output": {"entities": {}}, "schema": []}
{"input": "In cerebrospinal fluid, an ADA catalytic concentration above 0. 15 mu kat/L strongly suggests tuberculous meningitis in patients older than 7 years (sensitivity 1. 00, specificity 0. 99 and efficiency 0. 99).", "output": {"entities": {"gene": [{"text": "ADA", "start": 27, "end": 30}]}}, "schema": []}
{"input": "NERVTRACK contains 4000 anatomical data items arranged in a tree-like manner reflecting structural and functional relationships.", "output": {"entities": {}}, "schema": []}
{"input": "Perfusion washout: increasing a microvascular free flap tolerance to ischemia.", "output": {"entities": {}}, "schema": []}
{"input": "Similarly, the sequence of the U2 RNA region shown to be involved in pre-mRNA branchpoint recognition in yeast, and exactly conserved in metazoan U2 RNAs, was totally divergent in trypanosomes.", "output": {"entities": {"gene": [{"text": "U2 RNA region", "start": 31, "end": 44}, {"text": "metazoan U2 RNAs", "start": 137, "end": 153}]}}, "schema": []}
{"input": "It is striking that the active CHO spacer promoter violated the otherwise universal rule that metazoan RNA polymerase I promoters all have a G residue at position-16.", "output": {"entities": {"gene": [{"text": "metazoan RNA polymerase I promoters", "start": 94, "end": 129}]}}, "schema": []}
{"input": "Significant intergroup differences are highlighted for both selected dentoskeletal and soft tissue profile variables.", "output": {"entities": {}}, "schema": []}
{"input": "The author provides a rationale for an interactional view and presents a case in which post-surgical hiccups were successfully treated, using principles developed by the Mental Research Institute.", "output": {"entities": {}}, "schema": []}
{"input": "The relative toxicity of nickel oxide (NiO), nickel sulfate hexahydrate (NiSO4. 6H2O), and nickel subsulfide (Ni3S2) was studied in F344/N rats and B6C3F1 mice after inhalation exposure for 6 hr/day, 5 days/week, for 13 weeks.", "output": {"entities": {}}, "schema": []}
{"input": "Light microscopical and routine immunohistochemical studies of a cervical neoplasm in a 32 year old woman initially suggested a histiocytic lymphoma, but histochemical staining for chloroacetate esterase established the correct diagnosis.", "output": {"entities": {"gene": [{"text": "chloroacetate esterase", "start": 181, "end": 203}]}}, "schema": []}
{"input": "From the National Institutes of Health.", "output": {"entities": {}}, "schema": []}
{"input": "Molecular cloning and characterisation of the two homologous genes coding for nitrate reductase in tobacco.", "output": {"entities": {"gene": [{"text": "nitrate reductase in tobacco", "start": 78, "end": 106}]}}, "schema": []}
{"input": "In the final model, grade (p = 0. 0002), peritoneal cytologic results (p = 0. 0002), progesterone receptor status (p = 0. 004), and age as a continuous variable (p = 0. 008) were most closely associated with disease-free survival.", "output": {"entities": {"gene": [{"text": "progesterone receptor", "start": 85, "end": 106}]}}, "schema": []}
{"input": "In contrast, despite external radiation therapy, brain metastases proved fatal.", "output": {"entities": {}}, "schema": []}
{"input": "COUP transcription factor is a member of the steroid receptor superfamily.", "output": {"entities": {"gene": [{"text": "COUP transcription factor", "start": 0, "end": 25}, {"text": "steroid receptor superfamily", "start": 45, "end": 73}]}}, "schema": []}
{"input": "Cosmid clones containing both VNTR sequences were identified, and restriction mapping showed them to be less than 15 kb apart.", "output": {"entities": {}}, "schema": []}
{"input": "The oxygen uptake (VO2), carbon dioxide output (VCO2), respiratory rate (fR), minute ventilation (VE), alveolar ventilation (VA), alveolar oxygen pressure (PAO2), and VE/VO2 ratio were higher in the cows, while the tidal volume (VT) and physiological dead space (VD) were larger in the horses.", "output": {"entities": {}}, "schema": []}
{"input": "Epithelial damage was not observed in any controls but was in all tissues exposed to SO2.", "output": {"entities": {}}, "schema": []}
{"input": "The present study investigates whether prostaglandins \" cytoprotect \" the gastric mucosa against hemorrhage-induced stress ulceration by assessing the influence of 16, 16-dimethyl prostaglandin E2 (16, 16-dm PGE2) on gross and microscopic lesion formation, intramucosal tissue pH, H + back-diffusion, and mucosal blood flow in rat gastric mucosa exposed to luminal acid (100 mM HCl) during hemorrhagic shock (13 ml/kg for 20 min).", "output": {"entities": {}}, "schema": []}
{"input": "Transcripts characterized include (i) abundant monocistronic L11e and tricistronic L1e-L10e-L12e transcripts; (ii) less abundant bicistronic NAB-L11e and monocistronic NAB transcripts and (iii) a very rare ORF monocistronic transcript.", "output": {"entities": {"gene": [{"text": "L11e", "start": 61, "end": 65}, {"text": "L1e", "start": 83, "end": 86}, {"text": "L10e", "start": 87, "end": 91}, {"text": "L12e", "start": 92, "end": 96}, {"text": "NAB", "start": 141, "end": 144}, {"text": "L11e", "start": 145, "end": 149}, {"text": "NAB transcripts", "start": 168, "end": 183}]}}, "schema": []}
{"input": "Qualitatively, the results are similar for the two species: Both rhesus monkey and man have photopic and scotopic branches, which cross at approximately the same time in the dark and at approximately the same background luminance.", "output": {"entities": {}}, "schema": []}
{"input": "At each level of PaO2 we obtained simultaneous measures of arterial and venous blood gases, venous lactate concentration, and changes in the relative concentrations of inorganic phosphate, phosphocreatine, and ATP measured with 31P magnetic resonance spectroscopy.", "output": {"entities": {}}, "schema": []}
{"input": "Endometrial biopsies and plasma oestradiol (E2) and progesterone (P4) levels in 23 patients were evaluated during 26 replacement therapy cycles for premature ovarian failure.", "output": {"entities": {}}, "schema": []}
{"input": "The mobility of the upper and lower premolars under load was investigated in relation to the interproximal contact and occlusal facets.", "output": {"entities": {}}, "schema": []}
{"input": "This suggested that baboon liver class I ADH is of the same ancestral lineage as the human ADH-beta.", "output": {"entities": {"gene": [{"text": "baboon liver class I ADH", "start": 20, "end": 44}, {"text": "human ADH-beta", "start": 85, "end": 99}]}}, "schema": []}
{"input": "Each individual shot 25 bullets in about 5 minutes, at an intensity level calculated at 163 dB.", "output": {"entities": {}}, "schema": []}
{"input": "Dynamic and static scintigrams, using 99mtechnetium methylene diphosphonate, were obtained at zero, six, and 12 weeks after fracture.", "output": {"entities": {}}, "schema": []}
{"input": "On admission to our department in September, 1987, the patient was alert and had spastic paraparesis, the impairment of all sensory modalities below the level of Th 10 and urinary disturbance.", "output": {"entities": {}}, "schema": []}
{"input": "Prostaglandins and gallstones", "output": {"entities": {}}, "schema": []}
{"input": "The nature of the process formed by the successive occurrences of this arrhythmia was studied in 8 patients with a history of symptomatic paroxysmal AF.", "output": {"entities": {}}, "schema": []}
{"input": "This would have had the effect of positioning the genes currently on the long arm adjacent to the centromeric heterochromatin, perhaps resulting in a \" position effect \" on transcription of these genes.", "output": {"entities": {}}, "schema": []}
{"input": "Initial experience with a microprocessor controlled current based defibrillator.", "output": {"entities": {}}, "schema": []}
{"input": "Obesity was strongly associated with the proportions of nonprotein-bound and albumin-bound estradiol, and inversely associated with sex hormone binding globulin (SHBG) levels and the proportion of SHBG-bound estradiol.", "output": {"entities": {"gene": [{"text": "albumin", "start": 77, "end": 84}, {"text": "sex hormone binding globulin", "start": 132, "end": 160}, {"text": "SHBG", "start": 162, "end": 166}, {"text": "SHBG", "start": 197, "end": 201}]}}, "schema": []}
{"input": "Heterogeneous nuclear ribonucleoprotein (hnRNP) core protein A1 is a major component of mammalian hnRNP 40 S particles.", "output": {"entities": {"gene": [{"text": "Heterogeneous nuclear ribonucleoprotein (hnRNP) core protein A1", "start": 0, "end": 63}, {"text": "mammalian hnRNP 40 S particles", "start": 88, "end": 118}]}}, "schema": []}
{"input": "Brain cholinesterase activity of nestling great egrets, snowy egrets and black-crowned night-herons. inhibition of brain cholinesterase (ChE) activity in birds is often used to diagnose exposure or death from organophosphorus or carbamate pesticides.", "output": {"entities": {"gene": [{"text": "Brain cholinesterase", "start": 0, "end": 20}, {"text": "brain cholinesterase", "start": 115, "end": 135}, {"text": "ChE", "start": 137, "end": 140}]}}, "schema": []}
{"input": "The effect of zinc deficiency on trace metals in the liver, spleen, kidney, pancreas and duodenum was investigated in the control and zinc-deficient rats at 17 days and 20 days of pregnancy.", "output": {"entities": {}}, "schema": []}
{"input": "Our findings support the view of a multifactorial genesis of the cardiac involvement in uremic patients.", "output": {"entities": {}}, "schema": []}
{"input": "Heating cells to 43 degrees C decreased the amount of newly synthesized rRNA to less than 5% of the control level and led to greater than 95% inhibition of transcription termination at a region 355 to 362 nucleotides downstream of the 3' end of 28S rRNA, with readthrough continuing into the next transcription unit.", "output": {"entities": {"gene": [{"text": "28S rRNA", "start": 245, "end": 253}]}}, "schema": []}
{"input": "Deletion analysis showed that the NF-4FA, NF-4FB, and AP-1 sequences are each necessary for full enhancer activity.", "output": {"entities": {"gene": [{"text": "NF-4FA", "start": 34, "end": 40}, {"text": "NF-4FB", "start": 42, "end": 48}, {"text": "AP-1", "start": 54, "end": 58}]}}, "schema": []}
{"input": "Cord swelling was observed in 2 patients who developed complete lesions.", "output": {"entities": {}}, "schema": []}
{"input": "Reye' s syndrome: reports of 7 cases in the period 1982-1987", "output": {"entities": {}}, "schema": []}
{"input": "PULSE is used to set such NMR spectroscopic parameters as the delay and duration of rf transmit and receive gates, rf phase, sampling times, and such imaging parameters as rf pulse shape and gradient waveforms.", "output": {"entities": {}}, "schema": []}
{"input": "Definite JPsA (24 patients) was defined as arthritis associated, but not necessarily coincident, with a typical psoriatic rash, or arthritis plus at least 3 of 4 minor criteria: dactylitis, nail pitting, psoriasis-like rash, or family history of psoriasis.", "output": {"entities": {}}, "schema": []}
{"input": "Hence follows Kurti' s demand to mete out appropriate importance to the arguments.", "output": {"entities": {}}, "schema": []}
{"input": "The author gives an account of antipsychotic, analgetic, myorelaxing and vasodilatating effects of some calcium antagonists, and their clinical application is discussed.", "output": {"entities": {}}, "schema": []}
{"input": "A correlation coefficient was used for assessing the similarity of each map pattern with the normal mean IQRST map.", "output": {"entities": {}}, "schema": []}
{"input": "A hospital-based study of the relationship between retained placenta and mastitis in dairy cows.", "output": {"entities": {}}, "schema": []}
{"input": "This indicates that lipid peroxidation may be involved in the development of senile cataract and, as a direct consequence of retinal damage, also in the pathogenesis of cataract in diabetes and in severe myopia.", "output": {"entities": {}}, "schema": []}
{"input": "The histological grading was certified in 68 cases: 12 G1, 39 G2, 17 G3; extracapsular spread was found in 20/54 cases (37%).", "output": {"entities": {}}, "schema": []}
{"input": "Asthma was significantly more often associated with ASA group (91%) vs 46% at AT and in only 16% at INTR group.", "output": {"entities": {}}, "schema": []}
{"input": "A value of 1. 1 l/kg was used for V in calculating all single sample estimates of clearance (CL), and a value of 4. 3 l/kg was used to calculate single sample estimates of clearance of plasma unbound drug (CLunb).", "output": {"entities": {}}, "schema": []}
{"input": "The solitary kidney: a model of chronic hyperfiltration in humans.", "output": {"entities": {}}, "schema": []}
{"input": "Halothane is metabolized by an oxidative pathway to stable, nonvolatile end products, trifluoroacetic acid (TFAA) and bromide (Br-), and by reductive pathways to Br-and inorganic fluoride (F-).", "output": {"entities": {}}, "schema": []}
{"input": "The values were consistently lower (P less than 0. 01) during summer (3. 79 +/-0. 13 micrograms/100 ml), as compared to winter (5. 06 +/-0. 27).", "output": {"entities": {}}, "schema": []}
{"input": "These results suggest that HAPE-S-S are prone to irregular nocturnal breathing patterns at high altitude, which is associated with the development of AMS, but it was not possible to determine whether these abnormal breathing patterns are a cause or an effect of AMS.", "output": {"entities": {}}, "schema": []}
{"input": "It was possible to classify the animals into high and low responders according to the pattern of humoral immune response.", "output": {"entities": {}}, "schema": []}
{"input": "Heart rate (HR), rectal temperature (Tre), blood pressure, temperature and relative humidity changes inside clothing were measured on 18 professional firemen (mean age 29. 4 +/-7. 4 yr, VO2 max 41. 4 + 8. 8 ml kg-1 min-1) wearing fire fighter' s uniforms (SU) or aluminized, fire resistant, impermeable clothing with self contained breathing apparatus (FE).", "output": {"entities": {}}, "schema": []}
{"input": "The clinical tolerance and pharmacokinetics of FCE 22101 (sodium (5R, 6S)-6-[(1R)-hydroxyethyl]-2-carbamoyloxymethyl-2-penem-3-carboxylate), a new penem antibiotic, have been studied after giving a single i. v. dose of 4 mg. kg-1 to ten healthy male volunteers.", "output": {"entities": {}}, "schema": []}
{"input": "DNA blot hybridization suggests that the rat genome may contain more than one gene encoding PtdIns transfer protein.", "output": {"entities": {"gene": [{"text": "PtdIns transfer protein", "start": 92, "end": 115}]}}, "schema": []}
{"input": "Another segment of CRL3 (-296 to-184), also displaying enhancer function, contained tandem repeated sequences (DR-A1 and DR-A2).", "output": {"entities": {"gene": [{"text": "CRL3", "start": 19, "end": 23}]}}, "schema": []}
{"input": "1-(1-Naphthyl) piperazine (1-NP) has been reported to have serotonin antagonist properties at the 5-HT2 subtype of receptor, and it has been suggested that it may have agonist actions at the 5-HT1 site.", "output": {"entities": {"gene": [{"text": "5-HT2 subtype", "start": 98, "end": 111}, {"text": "5-HT1 site", "start": 191, "end": 201}]}}, "schema": []}
{"input": "1-(m-Chlorophenyl) piperazine (mCPP, 0. 1-3. 0 mg/kg) and 1-(m-trifluoromethylphenyl) piperazine (TFMPP, 0. 1-3. 0 mg/kg), both thought to act primarily at 5-HT1 sites, also decreased responding and this effect was blocked by methysergide and by 1-NP, but not by ketanserin.", "output": {"entities": {"gene": [{"text": "5-HT1 sites", "start": 156, "end": 167}]}}, "schema": []}
{"input": "The characteristic feature of liver and spleen MP function in patients with VHA associated with HBsAg carriership consisted in the lack of the compensatory reaction on the part of spleen MP, which was likely to be connected with overstrain of long standing and depletion of the MP system due to permanent antigenic stimulation of HBsAg.", "output": {"entities": {"gene": [{"text": "HBsAg", "start": 96, "end": 101}, {"text": "HBsAg", "start": 330, "end": 335}]}}, "schema": []}
{"input": "Changes in xanthine oxidase activity in patients with circulatory failure", "output": {"entities": {"gene": [{"text": "xanthine oxidase", "start": 11, "end": 27}]}}, "schema": []}
{"input": "A soap and water (1: 1, v/v) solution effectively decontaminated powdered stratum corneum.", "output": {"entities": {}}, "schema": []}
{"input": "The cytoprotective and antiulcer activities of the antacid magaldrate (ES Riopan) as well as its effects on gastric mucosal blood flow and mucus secretions, were determined in the rat.", "output": {"entities": {}}, "schema": []}
{"input": "The human immunodeficiency virus type 1 (HIV-1) preferentially infects CD4 + T lymphocytes and may exist as a latent provirus within these cells for extended periods.", "output": {"entities": {"gene": [{"text": "CD4 +", "start": 71, "end": 76}]}}, "schema": []}
{"input": "Histiocytic panniculitis was observed in biopsy specimens with cytophagocytosis.", "output": {"entities": {}}, "schema": []}
{"input": "We have utilized the human 4F2 heavy chain (4F2HC) gene as a model system in studies designed to elucidate the molecular events involved in regulating inducible gene expression during normal human T-cell activation.", "output": {"entities": {"gene": [{"text": "human 4F2 heavy chain", "start": 21, "end": 42}, {"text": "4F2HC", "start": 44, "end": 49}]}}, "schema": []}
{"input": "A cDNA encoding the NF-4FB enhancer binding protein has been cloned by screening a lambda gt11 cDNA library with a rabiolabelled oligonucleotide corresponding to the NF-4FB recognition sequence.", "output": {"entities": {"gene": [{"text": "NF-4FB enhancer binding protein", "start": 20, "end": 51}, {"text": "NF-4FB recognition sequence", "start": 166, "end": 193}]}}, "schema": []}
{"input": "Electrocardiographic right ventricular hypertrophy was seen in 4, and biventricular hypertrophy in 5 patients.", "output": {"entities": {}}, "schema": []}
{"input": "Sequencing analysis revealed that the 0. 54-and 0. 4-kb fragments are identical except for 150 nucleotides missing at the 5' region of the 0. 4-kb fragment.", "output": {"entities": {}}, "schema": []}
{"input": "The mature protein also contains a cysteine-rich, highly hydrophilic region homologous to the ovomucoid serine protease inhibitors (residues 76-132).", "output": {"entities": {"gene": [{"text": "ovomucoid serine protease inhibitors", "start": 94, "end": 130}]}}, "schema": []}
{"input": "Oligosynaptic EPSP components were consistently modulated only in the superficial peroneal responses in flexor motoneurons, which exhibited enhanced amplitude during the flexion phase.", "output": {"entities": {}}, "schema": []}
{"input": "Experiments on 23 white rats and 10 guinea pigs have shown that preliminarily indomethacin-induced inhibition of prostaglandins synthesis prevented development of pulmonary oedema, evoked by heterologous serum in rats and by vagotomy in guinea pigs.", "output": {"entities": {}}, "schema": []}
{"input": "On the other hand, lack of conservation of the membrane attachment sequence arginine-glycine-aspartic acid argues against its functional importance in CgA.", "output": {"entities": {"gene": [{"text": "CgA", "start": 151, "end": 154}]}}, "schema": []}
{"input": "Third-and later-parity cows were randomly assigned after each parturition to Charolais and Red Poll bulls in multiple-sire pastures.", "output": {"entities": {}}, "schema": []}
{"input": "Within each lobe, the PA dispersion was up to 10 cmH2O at CFV of 90 l/min; when flow decreased, PA at all sites decreased, as did the intralobar dispersion.", "output": {"entities": {}}, "schema": []}
{"input": "The system consisted of the intact canine heart connected to a microcomputer that operated as the modulated parasystolic pacemaker.", "output": {"entities": {}}, "schema": []}
{"input": "In order to identify and classify the basic CT appearances of interstitial pneumonia, radiologic-pathologic correlative study was performed using inflated and fixed lungs from autopsy and surgery.", "output": {"entities": {}}, "schema": []}
{"input": "The disease ran an atypical course; with early jaundice syndrome, severe enterorrhagia and late appearance of roseola.", "output": {"entities": {}}, "schema": []}
{"input": "The transcription factor Sp1 bound to eight sites, as demonstrated by footprinting assays and gel shift analysis with purified Sp1.", "output": {"entities": {"gene": [{"text": "Sp1", "start": 25, "end": 28}, {"text": "Sp1", "start": 127, "end": 130}]}}, "schema": []}
{"input": "The combination PIP 64 micrograms-PEF 4 micrograms prevents the frequent secondary regrowth seen after 6 hours with the antibiotics used alone.", "output": {"entities": {}}, "schema": []}
{"input": "With a sample of mothers of healthy infants, all three subscales of the revised instrument, WPL-R, had acceptable levels of internal consistency at 7, 30, and 90 days postpartum, and stability across administrations.", "output": {"entities": {}}, "schema": []}
{"input": "Since 1948, the use of saline-washed red cells (WRBCs) has been advocated to minimize hemolysis after transfusion to patients with PNH.", "output": {"entities": {}}, "schema": []}
{"input": "In the group of asthmatics statistically significant correlation was found between PC20 PGF2 alpha and histamine values (r = 0. 538, p less than 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "Acute experiments on nembutal-anesthetized cats (50 mg/kg) were employed to investigate the effect of 1 T pulsating magnetic field (PMF) on neuromuscular system of the leg.", "output": {"entities": {}}, "schema": []}
{"input": "No significant differences were found between the TS and the PTS.", "output": {"entities": {}}, "schema": []}
{"input": "The percentages of formed cysts and growth rates were monthly estimated and analyzed rhythmometrically by cosinor for 5 clonal cultures of Scripsiella trochoidea Stein grown for 2 years under laboratory conditions, rended as constant as possible from the view point of environmental temperature (24 +/-1 degree C), lighting (25 microEin m-2 s-1), and artificial seawater.", "output": {"entities": {}}, "schema": []}
{"input": "A genomic DNA clone encoding oryzacystatin (Oc), a cysteine proteinase inhibitor (cystatin) of rice, was isolated from a lambda EMBL3 phage library constructed with Sau3AI partial digests of rice chromosomal DNA, by screening with an oc cDNA as a probe.", "output": {"entities": {"gene": [{"text": "oryzacystatin", "start": 29, "end": 42}, {"text": "Oc", "start": 44, "end": 46}, {"text": "cysteine proteinase", "start": 51, "end": 70}, {"text": "cystatin", "start": 82, "end": 90}, {"text": "Sau3AI", "start": 165, "end": 171}, {"text": "oc cDNA", "start": 234, "end": 241}]}}, "schema": []}
{"input": "The use of an appropriate solution of methylene blue (0. 2% in 0. 9 M NaCl for 15 min) permits the staining of premalignant areas and CIS, and their early diagnosis.", "output": {"entities": {}}, "schema": []}
{"input": "Lower limits (to 10 micrograms/kg) were detectable, but with lower reliability (60%).", "output": {"entities": {}}, "schema": []}
{"input": "Instead, some small negative effects are observed, particularly involving effects of husbands' retirement on the marital satisfaction of employed wives.", "output": {"entities": {}}, "schema": []}
{"input": "This in turn will further enhance the role of meta-analysis in helping clinicians and policy makers answer clinical questions.", "output": {"entities": {}}, "schema": []}
{"input": "The accuracies of presence or absence of neuroblastoma were compared between 131I-MIBG imaging and several tumor markers.", "output": {"entities": {}}, "schema": []}
{"input": "The congenital forms (7 cases) all occurred in female infants and involved the mucosa overlying either the anterior ridge of the maxilla or the mandible.", "output": {"entities": {}}, "schema": []}
{"input": "Immunohistochemical studies revealed positive staining for S100 protein in all the granular cell tumors of the adult but in none of the congenital granular cell epulides.", "output": {"entities": {"gene": [{"text": "S100 protein", "start": 59, "end": 71}]}}, "schema": []}
{"input": "We also found that the same males, breeding in different years on the same territories, had significantly larger harems in the years they had familiar neighbors.", "output": {"entities": {}}, "schema": []}
{"input": "Male-enhanced antigen gene is phylogenetically conserved and expressed at late stages of spermatogenesis.", "output": {"entities": {"gene": [{"text": "Male-enhanced antigen gene", "start": 0, "end": 26}]}}, "schema": []}
{"input": "In rats bearing Walker-256-carcinosarcoma 4-EPI was effective. (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {}}, "schema": []}
{"input": "Pacing the Roux limb abolished the ectopic pacemakers, restored the slow emptying of liquids to the more rapid rate found in the Billroth dogs (t1/2: paced Roux, 72 +/-15 minutes; Billroth, 43 +/-9 minutes; p greater than 0. 05) and did not change emptying of solids.", "output": {"entities": {}}, "schema": []}
{"input": "The treatments were 60 mg t. i. d. and 120 mg t. i. d. during 14 days' treatment, with the last dose pulsed with 1. 85 MBq [14C] diltiazem.", "output": {"entities": {}}, "schema": []}
{"input": "The subepicardial lymphatic capillaries were ramified and anastomosed with each other to form a relatively dense network which extended over the entire surface of both ventricles.", "output": {"entities": {}}, "schema": []}
{"input": "The examination must include T1 and T2 sequences and scans in three planes.", "output": {"entities": {}}, "schema": []}
{"input": "A great deal of information is available on the morphology of the claustrum in various animal species, as well as on its neuronal distribution and relationships with the cerebral cortex and other nuclei.", "output": {"entities": {}}, "schema": []}
{"input": "Low-grade glioma.", "output": {"entities": {}}, "schema": []}
{"input": "In terms of sequence repetitions, seven tandemly repeated copies of the hexanucleotide ATTGTT and three flanking regions of dyad symmetry were detected, all in ORF T3C.", "output": {"entities": {}}, "schema": []}
{"input": "The significance of these palindromic domains in this ORF is unclear but the coincidence of the end of one larger palindrome with the end of the translated protein sequence that has homology with the B chain of insulin suggests that the palindromes may divide the T2 protein into several functional units.", "output": {"entities": {"gene": [{"text": "insulin", "start": 211, "end": 218}, {"text": "T2 protein", "start": 264, "end": 274}]}}, "schema": []}
{"input": "During sub-maximal exercise, DCR in the UT dogs decreased from a resting value of 4. 08 +/-0. 18 mm Hg X ml-1 X min-1 to 1. 91 +/-0. 17 mm Hg X ml-1 X min-1 at a workload of 6. 4 kph (speed)/16% (grade).", "output": {"entities": {}}, "schema": []}
{"input": "7.", "output": {"entities": {}}, "schema": []}
{"input": "These data suggest that the G-protein gene family may be distributed over at least two human chromosomes.", "output": {"entities": {"gene": [{"text": "G-protein gene family", "start": 28, "end": 49}]}}, "schema": []}
{"input": "The major inserted DNA has no significant homology to published human nucleic acid sequences.", "output": {"entities": {}}, "schema": []}
{"input": "We have also found that the in vitro interaction between the SV40 octamer motif and the lymphoid cell-specific protein oct-B2 was negatively modulated by a component present in the nuclear extracts from several lymphoid cell lines.", "output": {"entities": {"gene": [{"text": "lymphoid cell-specific protein oct-B2", "start": 88, "end": 125}]}}, "schema": []}
{"input": "Anoxia was introduced by perfusing the gill with water deprived of oxygen or by halting the water flow to the gill.", "output": {"entities": {}}, "schema": []}
{"input": "Growth, 4-PA and 14C turnover data indicated that WB contributed to B-6 intake of these rats.", "output": {"entities": {}}, "schema": []}
{"input": "DNA sequence analysis revealed that these clones encode two distinct forms of translocase.", "output": {"entities": {"gene": [{"text": "translocase", "start": 78, "end": 89}]}}, "schema": []}
{"input": "RPA190 encodes a polypeptide chain of 186, 270 daltons in a large uninterrupted reading frame.", "output": {"entities": {"gene": [{"text": "RPA190", "start": 0, "end": 6}]}}, "schema": []}
{"input": "Both the intact A1 protein and its proteolytic fragment, the UP1 protein, can be cleaved by Staphylococcus aureus V-8 protease to produce two polypeptides of 92 amino acids.", "output": {"entities": {"gene": [{"text": "intact A1 protein", "start": 9, "end": 26}, {"text": "UP1 protein", "start": 61, "end": 72}, {"text": "Staphylococcus aureus V-8 protease", "start": 92, "end": 126}]}}, "schema": []}
{"input": "Irmiere, and W.", "output": {"entities": {}}, "schema": []}
{"input": "These offspring of the alpha-MSH treated mothers were less sensitive to pain and as adults showed a reduced analgesic response to morphine.", "output": {"entities": {"gene": [{"text": "alpha-MSH", "start": 23, "end": 32}]}}, "schema": []}
{"input": "Simian immunodeficiency virus (SIV) is a lentivirus with morphological and antigenic similarities to human immunodeficiency virus, the causative agent of acquired immunodeficiency syndrome (AIDS) of humans.", "output": {"entities": {}}, "schema": []}
{"input": "The lack of change in the ratio of the two spliced products expressed from either the normal or the 5'-rearranged myb further indicates that the insertion of the unique 121 amino acids in the larger myb transcripts is not a consequence of tumor-specific activation of the mouse myb oncogene.", "output": {"entities": {"gene": [{"text": "5'-rearranged myb", "start": 100, "end": 117}, {"text": "myb transcripts", "start": 199, "end": 214}, {"text": "mouse myb oncogene", "start": 272, "end": 290}]}}, "schema": []}
{"input": "The use of CRF-41 in the differential diagnosis of Cushing' s syndrome and obesity.", "output": {"entities": {"gene": [{"text": "CRF-41", "start": 11, "end": 17}]}}, "schema": []}
{"input": "We detected mos transcripts by Northern (RNA) analyses in RNA prepared from chicken and quail ovaries and testes.", "output": {"entities": {"gene": [{"text": "mos transcripts", "start": 12, "end": 27}]}}, "schema": []}
{"input": "The results suggest that the organization of functional units of the 72-bp repeat required for transcriptional enhancement of the early promoter is different from that required for late promoter function.", "output": {"entities": {}}, "schema": []}
{"input": "Variations in the 5' half of U3 were primarily due to insertions and deletions.", "output": {"entities": {}}, "schema": []}
{"input": "An analysis of the steady state RNA levels in T-lymphoid cell lines showed that at least three different incomplete proviral transcripts and their spliced products made up the majority of expressed RD-114 mRNA, and further demonstrated that partially deleted proviral loci have the potential to be transcriptionally vigorous in certain feline cell types.", "output": {"entities": {"gene": [{"text": "RD-114 mRNA", "start": 198, "end": 209}]}}, "schema": []}
{"input": "Either two or more different sequences can promote cleavage, or a single element exists which is long and diffuse.", "output": {"entities": {}}, "schema": []}
{"input": "Low molecular weight heparins have stimulated much interest because of their supposedly more selective action on Xa factor.", "output": {"entities": {"gene": [{"text": "Xa factor", "start": 113, "end": 122}]}}, "schema": []}
{"input": "Sodium dodecyl sulphate-induced cleavage by eukaryotic topoisomerase I is known to yield enzyme covalently attached to the 3' cut end of the DNA.", "output": {"entities": {"gene": [{"text": "eukaryotic topoisomerase I", "start": 44, "end": 70}]}}, "schema": []}
{"input": "Amino acid sequence of one human liver clone (HL-14) was identical to the rabbit skeletal muscle phosphatase 2A cDNA (with 97% nucleotide identity).", "output": {"entities": {"gene": [{"text": "rabbit skeletal muscle phosphatase 2A cDNA", "start": 74, "end": 116}]}}, "schema": []}
{"input": "Herpes virus infection was characterized by inversion of the T4/T8 ratio below 1. 0 (sensitivity 90%, specificity 88%), caused by proliferation of the T8 subpopulation, which--compared with the findings in patients with rejection crises--was significantly raised (P less than 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "Quantitative assays in which the activity of the synthetic alpha s-1 was compared to that of native purified human erythrocyte type-1 Gs, indicated that the two products are equipotent within a 2-fold margin of error.", "output": {"entities": {"gene": [{"text": "synthetic alpha s-1", "start": 49, "end": 68}, {"text": "human erythrocyte type-1 Gs", "start": 109, "end": 136}]}}, "schema": []}
{"input": "In these cells, E2 proteins had little or no stimulatory effect on the transcriptional activity of the HPV-11 enhancer-SV40 promoter.", "output": {"entities": {"gene": [{"text": "E2 proteins", "start": 16, "end": 27}, {"text": "HPV-11 enhancer", "start": 103, "end": 118}, {"text": "SV40 promoter", "start": 119, "end": 132}]}}, "schema": []}
{"input": "The mechanism by which E2-C represses E2-dependent enhancer activity most likely involves competition with E2 for binding to a common transcriptional regulatory site. (ABSTRACT TRUNCATED AT 400 WORDS)", "output": {"entities": {"gene": [{"text": "E2-C", "start": 23, "end": 27}, {"text": "E2-dependent enhancer", "start": 38, "end": 59}, {"text": "E2", "start": 107, "end": 109}]}}, "schema": []}
{"input": "Accurate evaluation of the treatment results in unresectable lung cancer patients must take the strong prognostic factors into account.", "output": {"entities": {}}, "schema": []}
{"input": "(anti-IIa) and Holmer et al.", "output": {"entities": {"gene": [{"text": "anti-IIa", "start": 1, "end": 9}]}}, "schema": []}
{"input": "Introduction of v-fms into a CSF-1 dependent murine macrophage cell line induced factor independence and tumorigenicity by a nonautocrine mechanism.", "output": {"entities": {"gene": [{"text": "v-fms", "start": 16, "end": 21}, {"text": "CSF-1", "start": 29, "end": 34}]}}, "schema": []}
{"input": "Chronic E-B virus infection terminated in malignant lymphoma: a case report", "output": {"entities": {}}, "schema": []}
{"input": "Whereas the muscle isoform consists of 997 amino acids and terminates with the sequence Ala-Ile-Leu-Glu, the second isoform is 1043 amino acids in length due to the replacement of these last 4 amino acids with a 50-amino acid sequence that contains a potential transmembrane domain followed by a consensus sequence for an N-linked glycosylation site.", "output": {"entities": {}}, "schema": []}
{"input": "Substitution of a threonine residue by an alanine residue at position-2 (P2) of this cleavage site abolished cleavage, whereas substitution of a tyrosine residue by a phenylalanine residue at amino acid position-1 (P1) of the cleavage site did not influence processing.", "output": {"entities": {}}, "schema": []}
{"input": "A highly hydrophobic sequence located near the carboxyl-terminal extremity of the molecule most likely constitutes the anchor to the plasma membrane.", "output": {"entities": {}}, "schema": []}
{"input": "The SV40 enhancer augmented replication 1. 5-10 fold.", "output": {"entities": {"gene": [{"text": "SV40 enhancer", "start": 4, "end": 17}]}}, "schema": []}
{"input": "One of these, the origin core, is required only for DNA replication.", "output": {"entities": {}}, "schema": []}
{"input": "Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element.", "output": {"entities": {"gene": [{"text": "proto-oncogene fos", "start": 13, "end": 31}, {"text": "adenylate cyclase", "start": 58, "end": 75}]}}, "schema": []}
{"input": "A 17-mer oligodeoxynucleotide, corresponding to a region of the VtHb amino acid sequence was used as a hybridization probe to screen a Vitreoscilla genomic library constructed in broad-host-range cosmid vector pVK102.", "output": {"entities": {"gene": [{"text": "VtHb amino acid sequence", "start": 64, "end": 88}]}}, "schema": []}
{"input": "(total soluble solids) and organoleptic characteristics under the influence of different treatments.", "output": {"entities": {}}, "schema": []}
{"input": "Causes of death found in an epidemiological study of native chickens in Thai villages.", "output": {"entities": {}}, "schema": []}
{"input": "The progression of non-A, non-B hepatitis to chronic diseases, and the transformation to hepatocellular carcinoma", "output": {"entities": {}}, "schema": []}
{"input": "Elevated IOP developed in 35 patients (44 eyes) during the study.", "output": {"entities": {}}, "schema": []}
{"input": "Use of serum thyroglobulin determination in the follow-up of differentiated carcinomas of the thyroid", "output": {"entities": {"gene": [{"text": "thyroglobulin", "start": 13, "end": 26}]}}, "schema": []}
{"input": "Poor response when laboratory recommended range for serum lithium is changed.", "output": {"entities": {}}, "schema": []}
{"input": "The aim of this study was to investigate the effects of nebulized ipratropium in patients with acute asthma in order to determine whether it augments the bronchodilator effect of a beta agonist drug.", "output": {"entities": {}}, "schema": []}
{"input": "Further analysis of this DNA fragment showed that four genes are present encoding proteins of 16, 18. 5, 21 and 89 kDal.", "output": {"entities": {}}, "schema": []}
{"input": "Hantaan virus.", "output": {"entities": {}}, "schema": []}
{"input": "Changes in dopamine receptor sensitivity in humans after heavy alcohol intake.", "output": {"entities": {"gene": [{"text": "dopamine receptor", "start": 11, "end": 28}]}}, "schema": []}
{"input": "No significant differences between the two treatment groups were found, but rapid responders had a smaller mean initial platelet-associated IgG index which returned more rapidly and more permanently to normal than that of slow responders.", "output": {"entities": {"gene": [{"text": "platelet-associated IgG", "start": 120, "end": 143}]}}, "schema": []}
{"input": "Replacement variant histone genes contain intervening sequences.", "output": {"entities": {"gene": [{"text": "Replacement variant histone genes", "start": 0, "end": 33}]}}, "schema": []}
{"input": "Double-blind randomised trial of intravenous tissue-type plasminogen activator versus placebo in acute myocardial infarction.", "output": {"entities": {"gene": [{"text": "tissue-type plasminogen activator", "start": 45, "end": 78}]}}, "schema": []}
{"input": "The C-terminal domains (CTDs) of the RPase beta subunit and DNA primase (dnaG protein) were not only strongly homologous to each other but also considerably homologous to the RPase alpha, suggesting that an alpha subunit-like enzyme must have been commonly ancestral to core enzyme subunits and primase.", "output": {"entities": {"gene": [{"text": "RPase beta subunit", "start": 37, "end": 55}, {"text": "DNA primase", "start": 60, "end": 71}, {"text": "dnaG protein", "start": 73, "end": 85}, {"text": "RPase alpha", "start": 175, "end": 186}, {"text": "core enzyme subunits", "start": 270, "end": 290}, {"text": "primase", "start": 295, "end": 302}]}}, "schema": []}
{"input": "However, vancomycin and fosfomycin, which revealed suboptimal in vitro bactericidal activity, proved as efficacious as penicillin G and imipenem in an experimental mode of murine gas gangrene.", "output": {"entities": {}}, "schema": []}
{"input": "Fentanyl, a prototypic mu-opiate receptor agonist, has been previously shown to produce a syndrome characterized by marked analgesia and locomotor stimulation as well as tachycardia, tachypnoea and behavioural arousal.", "output": {"entities": {"gene": [{"text": "mu-opiate receptor", "start": 23, "end": 41}]}}, "schema": []}
{"input": "Bisoprolol was found to be an effective beta-adrenoceptor antagonist, the pA2 values determined against isoprenaline in guinea pig atria and tracheal muscle being 7. 45 and 6. 41, respectively.", "output": {"entities": {"gene": [{"text": "beta-adrenoceptor", "start": 40, "end": 57}]}}, "schema": []}
{"input": "Output of 99mTcO-4 by the parotid gland closely mimicked fluctuations in parotid saliva flow rate.", "output": {"entities": {}}, "schema": []}
{"input": "The Hagen-Poiseuille equation is used to assess the effects of attached parasites in the foregut of Leishmania-infected sandflies on blood flow.", "output": {"entities": {}}, "schema": []}
{"input": "Moreover, in rats allowed to choose in a T-maze between immediate-but-small vs. delayed-but-large reward, BZP significantly decreased the frequency with which the delayed reward was chosen, with 5-HT uptake blockers producing opposite effects.", "output": {"entities": {}}, "schema": []}
{"input": "An endometrial luteal phase deficiency was detected in 15 (30%) of aborting patients.", "output": {"entities": {}}, "schema": []}
{"input": "Prenatal exposure to the fungicide dinocap causes behavioral torticollis, ballooning and cleft palate in mice, but not rats or hamsters.", "output": {"entities": {}}, "schema": []}
{"input": "Reperfusion with normal blood in the beating, working hearts caused extensive structural damage, reduced reflow, and failed to restore contractility in any instance (-27% systolic shortening, p less than 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "The sensitivity of the vas deferens to adrenaline was also reduced in scorbutic guinea pigs, thus decreasing their fertility rate.", "output": {"entities": {}}, "schema": []}
{"input": "In metabolic acidosis there was a marked stimulation when clamped at-10 to-100 mV.", "output": {"entities": {}}, "schema": []}
{"input": "On Days 1 and 14, most young and elderly subjects exhibited monoexponential decline in bevantolol plasma concentrations after absorption phase.", "output": {"entities": {}}, "schema": []}
{"input": "Mature and old B6AF1 and B6D2F1 mice were given acidified tap water or promethazine HCl (a phenothiazine with H1 receptor blocking activity), chlorpheniramine (an H1 blocker) or trifluoperazine (a phenothiazine with no H1 blocking activity) in their drinking water, and the effects of these agents on bone mineral content were assessed by intermittently measuring the 24-h whole body retention of Tc 99m methylene diphosphonate (Tc 99m MDP, an indicator of bone metabolism) and at the end of the studies by determining ash weights of femur, ilium and sacrum.", "output": {"entities": {"gene": [{"text": "H1 receptor", "start": 110, "end": 121}, {"text": "H1", "start": 163, "end": 165}, {"text": "H1", "start": 219, "end": 221}]}}, "schema": []}
{"input": "Present results reveal a frequency-dependent inhibition of ganglionic transmission by diltiazem, and suggest that diltiazem may depress excessive sympathetic activity without affecting normal ganglionic transmission.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of a new antihypertensive agent, SGB-1534, on rat platelet aggregation.", "output": {"entities": {}}, "schema": []}
{"input": "Since the stability of TF1 resides in its primary structure, we cloned a gene coding for TF1, and the primary structure of the beta subunit was deduced from the nucleotide sequence of the gene to compare the sequence with those of beta' s of three major categories of F1' s; prokaryotic membranes, chloroplasts, and mitochondria.", "output": {"entities": {"gene": [{"text": "TF1", "start": 23, "end": 26}, {"text": "TF1", "start": 89, "end": 92}, {"text": "F1", "start": 268, "end": 270}]}}, "schema": []}
{"input": "Body temperature and overall conductance in the cold appear to be more variable in P. s. campbelli than in nominative sp.", "output": {"entities": {}}, "schema": []}
{"input": "A drug with ISA \" down regulates \" beta receptors; thus, when the drug is withdrawn there is no post-beta-blocking drug hypersensitivity in contrast to agents without ISA.", "output": {"entities": {"gene": [{"text": "beta receptors", "start": 35, "end": 49}]}}, "schema": []}
{"input": "Six patients with human T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM) were studied by electrophysiologic methods.", "output": {"entities": {}}, "schema": []}
{"input": "Terazosin, a structural analog of prazosin, also inhibits alpha 1 adrenoceptors and is recommended as once or twice-daily therapy.", "output": {"entities": {"gene": [{"text": "alpha 1 adrenoceptors", "start": 58, "end": 79}]}}, "schema": []}
{"input": "Testing blood donors for non-A, non-B hepatitis: irrational, perhaps, but inescapable.", "output": {"entities": {}}, "schema": []}
{"input": "Most patients with high blood pressure (BP) can be managed by using one of 4 classes of compounds: a diuretic, beta blocker, converting enzyme inhibitor or calcium antagonist.", "output": {"entities": {}}, "schema": []}
{"input": "In a randomised double-blind study, 46 first episode schizophrenics were given pimozide or flupenthixol for up to 5 weeks; the mean daily dose at the end was 18. 8 mg pimozide and 20 mg flupenthixol.", "output": {"entities": {}}, "schema": []}
{"input": "Somatostatin-producing endocrine pancreatic tumor in Recklinghausen' s neurofibromatosis.", "output": {"entities": {"gene": [{"text": "Somatostatin", "start": 0, "end": 12}]}}, "schema": []}
{"input": "Direct and inverted repeat elements of 10, 11, 16, 19, and 22 nucleotides (nt) flank the promoter site.", "output": {"entities": {}}, "schema": []}
{"input": "We have been able to map specific DNA fragments at the bases of chromatin loops with the help of a novel extraction procedure by using lithium-3', 5'-diiodosalicylate.", "output": {"entities": {}}, "schema": []}
{"input": "Seventy-one supplementary doses of vecuronium were used for muscle relaxation during a 22-h-long NLA II anaesthesia.", "output": {"entities": {}}, "schema": []}
{"input": "Finally, the recovery indexes represented by the times required for T1/T0 and T4/T1 to rise from 25% to 75% respectively were studied.", "output": {"entities": {}}, "schema": []}
{"input": "Transformed bacterial colonies were screened for recombinant plasmids containing cDNA coding for BiP by hybrid-selected mRNA translation.", "output": {"entities": {"gene": [{"text": "BiP", "start": 97, "end": 100}]}}, "schema": []}
{"input": "DPA attenuated the increase of the intensity of the ischemic and pressure pain components with increasing ischemia duration, but only the effect on the pressure pain component was significant.", "output": {"entities": {}}, "schema": []}
{"input": "Topical 1 percent isoproterenol in the presence of the phosphodiesterase inhibitor theophylline was tested for its ability to stimulate the rate of aqueous humor flow through the anterior chamber of the normal and the partially adrenergically denervated human eye (Horner' s syndrome).", "output": {"entities": {}}, "schema": []}
{"input": "Hyperthyroidism is one of the numerous causes of infertility and recurrent abortion.", "output": {"entities": {}}, "schema": []}
{"input": "A strong correlation exists between the numbers of CFU-GM transfused and the rate of granulocytes and platelets recovery.", "output": {"entities": {}}, "schema": []}
{"input": "Oestrogen implant overdose.", "output": {"entities": {}}, "schema": []}
{"input": "Three sequence elements are shown to be required for accurate and efficient transcription termination by RNA polymerase I (pol I) assayed both in a cell-free transcription system and in vivo after transfection of rDNA minigene constructs into 3T6 cells.", "output": {"entities": {"gene": [{"text": "RNA polymerase I", "start": 105, "end": 121}, {"text": "pol I", "start": 123, "end": 128}]}}, "schema": []}
{"input": "A new physiopathological treatment of HBV-related polyarteritis inspired by advances in the treatment of chronic active hepatitis B was tested in 7 patients.", "output": {"entities": {}}, "schema": []}
{"input": "The subunit-a gene is preceded by a gene coding for a small hydrophobic protein, as has been observed previously in the atp operons in E. coli, bacterium PS3 and cyanobacteria.", "output": {"entities": {"gene": [{"text": "subunit-a gene", "start": 4, "end": 18}, {"text": "atp operons", "start": 120, "end": 131}]}}, "schema": []}
{"input": "Here, we describe the isolation of bovine and rat GHF-1 cDNA clones.", "output": {"entities": {"gene": [{"text": "bovine and rat GHF-1 cDNA", "start": 35, "end": 60}]}}, "schema": []}
{"input": "To explore the functional properties of the protein encoded by neu, we created a fusion gene that joins the cytoplasmic domain of neu to the extracellular portion of an immunoglobulin heavy chain.", "output": {"entities": {"gene": [{"text": "neu", "start": 63, "end": 66}, {"text": "neu", "start": 130, "end": 133}, {"text": "immunoglobulin heavy chain", "start": 169, "end": 195}]}}, "schema": []}
{"input": "By sequence comparison, 42 blocks of homology are defined in the 5'-terminal region, of which 36 appear in the CpG island and contain numerous conserved CpG dinucleotides.", "output": {"entities": {}}, "schema": []}
{"input": "Among unusual features, we report numerous large G + C-rich conserved sequences located in the first intron.", "output": {"entities": {}}, "schema": []}
{"input": "In the first group, 0. 02% Prazosin (0. 5 mg/kg) was administered intravenously for 1. 5 hours before the application of Oxy-Hb or PGF2 alpha.", "output": {"entities": {}}, "schema": []}
{"input": "A decamer sequence, 5'-CGA-CCCCUCC-3', complementary to a conserved sequence adjacent to the enzymatic cleavage site on the mitochondrial RNA substrate, is present in the RNAase MRP RNA.", "output": {"entities": {"gene": [{"text": "RNAase MRP RNA", "start": 171, "end": 185}]}}, "schema": []}
{"input": "Effects of aging and beta-adrenergic-blockade on standing-induced QT/QS2 changes.", "output": {"entities": {}}, "schema": []}
{"input": "A patient with an infected wound or one on a primary area (hands, feet, face, or perineum) may have to be hospitalized to ensure proper care.", "output": {"entities": {}}, "schema": []}
{"input": "Pharmacology studies with potassium chloride and acetylcholine suggest that raveron acts as a calcium antagonist by blocking the influx of extracellular calcium.", "output": {"entities": {}}, "schema": []}
{"input": "On admission to the ICU, 117 patients (61 percent) had hypomagnesemia (serum Mg less than 1. 5 mEq/dl), 66 patients (34 percent) had normomagnesemia (1. 5 to 2. 0 mEq/dl), and ten patients (5 percent) had hypermagnesemia (greater than 2. 0 mEq/dl).", "output": {"entities": {}}, "schema": []}
{"input": "The risk factors studied were male sex, hypertension, diabetes mellitus, hypercholesterolemia, cigarette smoking, sedentary life-style, and family history.", "output": {"entities": {}}, "schema": []}
{"input": "Neither verapamil nor nifedipine changed collateral myocardial blood flow from 0. 10 +/-0. 02 in the subendocardium and 0. 17 +/-0. 03 ml/min/g in the subepicardium.", "output": {"entities": {}}, "schema": []}
{"input": "There were 35 boys and 15 girls, with a mean age of five and a half years.", "output": {"entities": {}}, "schema": []}
{"input": "Controlled versus uncontrolled reperfusion of ischemic myocardium after experimental coronary artery occlusion was studied to determine the effect on regional ventricular wall motion and associated biochemical alterations.", "output": {"entities": {}}, "schema": []}
{"input": "Cardiac disease was not detected with M-mode, 2-dimensional real-time or pulsed-wave Doppler echocardiography.", "output": {"entities": {}}, "schema": []}
{"input": "Hemodynamic assessment was obtained before and following administration of digoxin 10 micrograms/kg IV or dopamine, 5 to 12 micrograms/kg/min IV.", "output": {"entities": {}}, "schema": []}
{"input": "We conclude that at these low levels studied, aluminum accumulates in intestinal tissue, and that this accumulation is enhanced by citrate ligand.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, the effects of father absence under routine conditions in relatively healthy samples may exert no significant effects independent of intervening family stressors or maternal psychopathology.", "output": {"entities": {}}, "schema": []}
{"input": "Recently, an electrical-mechanical analog model of heat flow within the brain has been developed from which an expression for CBF has been derived: CBF = Cb/(tau rho c) where tau is the thermal decay constant, rho is the density of blood, and c is its specific heat.", "output": {"entities": {}}, "schema": []}
{"input": "All of the newly acquired proviruses identified in mosaic founder SWR/J-RF/J mice that could be transmitted through the germ line were also present in somatic tissues, demonstrating that viral integration occurred before the germ line was set aside from the somatic lineages.", "output": {"entities": {}}, "schema": []}
{"input": "Molecular cloning of the cDNA for the human U2 snRNA-specific A' protein.", "output": {"entities": {"gene": [{"text": "human U2 snRNA-specific A' protein", "start": 38, "end": 72}]}}, "schema": []}
{"input": "For the present work we used water saturated with a 50/50 mixture of H2 and O2 gases, for which the heat defect is calculated to be-2. 1%.", "output": {"entities": {}}, "schema": []}
{"input": "During flexion whiplash, the torque at the occipital condyle reverses its direction at about 25 ms after impact.", "output": {"entities": {}}, "schema": []}
{"input": "The data indicates the presence of 5-HT2 serotonergic receptors in the bronchial artery of these species.", "output": {"entities": {"gene": [{"text": "5-HT2 serotonergic receptors", "start": 35, "end": 63}]}}, "schema": []}
{"input": "Oxfendazole, which was active for the shortest time (about 65 days) from the start of grazing (May 1), produced a 78. 1 per cent reduction in Ostertagia species and an 84. 4 per cent reduction in D viviparus.", "output": {"entities": {}}, "schema": []}
{"input": "By adapting a method for DNA-footprinting using impure extracts of ner overproducing cells, we were able to determine that the ner-binding sites are located between nucleotides 1026 and 1058 from the Mu left end.", "output": {"entities": {"gene": [{"text": "ner", "start": 67, "end": 70}, {"text": "ner-binding sites", "start": 127, "end": 144}]}}, "schema": []}
{"input": "Platelet function and platelet-polymorphonuclear-neutrophil interaction in patients with deficient platelet lipoxygenase activity.", "output": {"entities": {"gene": [{"text": "platelet lipoxygenase", "start": 99, "end": 120}]}}, "schema": []}
{"input": "Spontaneous degradation of atracurium in plasma is the major route of elimination in man and contributes to a short elimination half-life (approximatively 20 min).", "output": {"entities": {}}, "schema": []}
{"input": "Transformed cell lines expressing solely E1a or E1a and E1b gene products derived from these viruses display enhanced anchorage-independent growth at 37 degrees C versus 32 degrees C and display a cytoskeletal architecture resembling untransformed fibroblastic CREF cells.", "output": {"entities": {"gene": [{"text": "E1a", "start": 41, "end": 44}, {"text": "E1a", "start": 48, "end": 51}, {"text": "E1b gene products", "start": 56, "end": 73}]}}, "schema": []}
{"input": "Partial N-terminal amino acid sequence analysis showed that the 43K and 42K T antigens contain methionine at residues 1 and 5, as predicted from the DNA sequence, whereas no methionine was released from the 39K T antigen during the first six cycles of Edman degradation.", "output": {"entities": {"gene": [{"text": "43K and 42K T antigens", "start": 64, "end": 86}, {"text": "39K T antigen", "start": 207, "end": 220}]}}, "schema": []}
{"input": "Group A was treated with three or four doses of hepatitis B immune globulin (HBIG) in one of three different schedules.", "output": {"entities": {"gene": [{"text": "hepatitis B immune globulin", "start": 48, "end": 75}, {"text": "HBIG", "start": 77, "end": 81}]}}, "schema": []}
{"input": "In the former instance, in addition to serum calcium and phosphorous ion concentrations, tissue pH, blood supply, hormones, i. e., vitamin D, vitamin A, and various enzymes (e. g., alkaline phosphatase and pyrophosphatase) may all play significant, ancillary, time-dependent, but as yet undetermined roles.", "output": {"entities": {"gene": [{"text": "alkaline phosphatase", "start": 181, "end": 201}, {"text": "pyrophosphatase", "start": 206, "end": 221}]}}, "schema": []}
{"input": "Penicillinase production in Staphylococcus aureus strains of clinical importance.", "output": {"entities": {"gene": [{"text": "Penicillinase", "start": 0, "end": 13}]}}, "schema": []}
{"input": "Thus, quantitative analysis of thallium-201 uptake and washout provided objective evidence for improved myocardial perfusion after coronary angioplasty.", "output": {"entities": {}}, "schema": []}
{"input": "This study reports the effects of a preparation with 50 micrograms ethinyl estradiol and 2 mg cyproterone acetate on gonadotropins, prolactin, testosterone, sex hormone binding globulin (SHBG), androstenedione, and calculated free testosterone index before and after six months of treatment.", "output": {"entities": {"gene": [{"text": "gonadotropins", "start": 117, "end": 130}, {"text": "prolactin", "start": 132, "end": 141}, {"text": "sex hormone binding globulin", "start": 157, "end": 185}, {"text": "SHBG", "start": 187, "end": 191}]}}, "schema": []}
{"input": "In nine patients with renal failure routine haemodialysis was accompanied by a 30 per cent reduction in plasma ANP concentration.", "output": {"entities": {"gene": [{"text": "ANP", "start": 111, "end": 114}]}}, "schema": []}
{"input": "To investigate the effects of isotretinoin on HDL, we measured HDL-C, HDL phospholipids (HDL-PL), apoprotein A1 (apo A-1), and HDL-C subfractions (HDL2-C and HDL3-C) in 24 healthy, male patients receiving a 16-week course of isotretinoin (1. 0 mg/kg/day) for treatment of severe acne vulgaris.", "output": {"entities": {"gene": [{"text": "HDL", "start": 46, "end": 49}, {"text": "HDL-C", "start": 63, "end": 68}, {"text": "HDL", "start": 70, "end": 73}, {"text": "HDL-PL", "start": 89, "end": 95}, {"text": "apoprotein A1", "start": 98, "end": 111}, {"text": "apo A-1", "start": 113, "end": 120}, {"text": "HDL-C", "start": 127, "end": 132}, {"text": "HDL2-C", "start": 147, "end": 153}, {"text": "HDL3-C", "start": 158, "end": 164}]}}, "schema": []}
{"input": "The clinical picture and laboratory parameters were consistent with a serum sickness reaction.", "output": {"entities": {}}, "schema": []}
{"input": "Preventive effect of ONO-3708 on thrombosis and vasospasms in vitro and in vivo.", "output": {"entities": {}}, "schema": []}
{"input": "The frequency of PPNG strains increased from 1. 7% in 1981 to 6. 7% in 1985.", "output": {"entities": {}}, "schema": []}
{"input": "Monospecific antibodies, eluted from the beta-galactosidase fusion protein of either clone reacted with the U1 snRNP-specific A antigen.", "output": {"entities": {"gene": [{"text": "beta-galactosidase", "start": 41, "end": 59}, {"text": "U1 snRNP", "start": 108, "end": 116}, {"text": "A antigen", "start": 126, "end": 135}]}}, "schema": []}
{"input": "The pathogenesis of Limited Joint Mobility (LJM) in diabetes is unknown, but the abnormality is said to be associated with an increased incidence of microangiopathy.", "output": {"entities": {}}, "schema": []}
{"input": "The experimental end points were the time required for treated tumors to reach 3 times their treatment size, the survival of stem cells in the duodenal crypts, and the breathing rate measured early (19-23 weeks) and late (41-46 weeks) after treatment.", "output": {"entities": {}}, "schema": []}
{"input": "Schedule 2, in which 2. 4 mg/kg c-DDP was administered immediately before X-ray on 5 consecutive days produced the highest degree of enhancement of radiation effect (expressed as dose-effect factor); and the next greatest enhancement was produced by 12 mg/kg c-DDP administered 24 h before the start of fractionated daily radiotherapy.", "output": {"entities": {}}, "schema": []}
{"input": "The cpc-1-encoded transcript contains three open reading frames, two of which are located in the 720-nucleotide leader segment preceding the cpc-1 coding region.", "output": {"entities": {"gene": [{"text": "cpc-1-encoded transcript", "start": 4, "end": 28}, {"text": "cpc-1 coding region", "start": 141, "end": 160}]}}, "schema": []}
{"input": "The HOI induced a nearly fourfold increase in ANF in the elderly, whereas that for the young was threefold.", "output": {"entities": {"gene": [{"text": "ANF", "start": 46, "end": 49}]}}, "schema": []}
{"input": "To assess the ability of the atria to maintain elevated plasma concentrations of atrial natriuretic peptide (ANP), the temporal changes in plasma ANP concentrations were studied in seven chloralose-anaesthetized dogs during 4 h of sustained rapid cardiac pacing.", "output": {"entities": {"gene": [{"text": "atrial natriuretic peptide", "start": 81, "end": 107}, {"text": "ANP", "start": 109, "end": 112}, {"text": "plasma ANP", "start": 139, "end": 149}]}}, "schema": []}
{"input": "Ig D-JH recombinations may precede TcR gene recombination in these early T cell lines, and some but not all express sterile Cmu transcripts.", "output": {"entities": {"gene": [{"text": "Ig D", "start": 0, "end": 4}, {"text": "JH", "start": 5, "end": 7}, {"text": "TcR gene", "start": 35, "end": 43}, {"text": "Cmu transcripts", "start": 124, "end": 139}]}}, "schema": []}
{"input": "The RAD18 gene open reading frame encodes a protein of 487 amino acids, with a calculated molecular weight of 55, 512.", "output": {"entities": {"gene": [{"text": "RAD18 gene open reading frame", "start": 4, "end": 33}]}}, "schema": []}
{"input": "Atomic absorption spectrophotometry applied to bacterially expressed E1A proteins revealed that the 289-amino acid protein binds one zinc ion, whereas the 243-amino acid protein binds no zinc.", "output": {"entities": {"gene": [{"text": "E1A proteins", "start": 69, "end": 81}]}}, "schema": []}
{"input": "Most patients preferred tablets to injection both on day 1 (313 v 200) and at follow up (373 v 104).", "output": {"entities": {}}, "schema": []}
{"input": "Plots of RV, LV + S and 2A weight vs real hematocrit showed sharp upward inflections at real hematocrit 65%, suggesting a possible role of increased viscosity in CO cardiomegaly at the higher hematocrit.", "output": {"entities": {}}, "schema": []}
{"input": "The absorbable perisplenic mesh is an important improvement, and in some cases it may replace other techniques for arresting splenic bleeding.", "output": {"entities": {}}, "schema": []}
{"input": "A rare chronic course of Budd-Chiari syndrome associated with thrombosis of the portal vein was observed in a 30-year-old male patient suffering from postmyocarditic cardiosclerosis.", "output": {"entities": {}}, "schema": []}
{"input": "After one accommodation night, sleep EEG recordings were performed during three consecutive nights in ten drug-free inpatients presenting generalized anxiety disorder (GAD) with significant depression, compared with a age-and sex-matched group of patients with GAD and a group of primary major depressive disorder (MDD) patients.", "output": {"entities": {}}, "schema": []}
{"input": "Oligonucleotide mutagenesis of these binding domains indicated their importance in the transcriptional regulation of the E3 promoter in yeast cells.", "output": {"entities": {"gene": [{"text": "E3 promoter", "start": 121, "end": 132}]}}, "schema": []}
{"input": "The concentration of PGI2 on the newly-formed luminal surface remained low.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of single and combined maltose tetrapalmitate immunotherapy, cyclophosphamide chemotherapy and radiotherapy on ethyl carbamate accelerated primary lung cancer in A/J mice.", "output": {"entities": {}}, "schema": []}
{"input": "D.", "output": {"entities": {}}, "schema": []}
{"input": "Phase II study of VP-16 (capsule) in solid tumors.", "output": {"entities": {}}, "schema": []}
{"input": "When the coding segments, including both framework and complementarity-determining regions, of these genes and the murine probe sequences are compared by metric analysis, it is apparent that the caiman genes are only slightly more related to each other than to the mammalian sequence, consistent with significant preservation of nucleotide sequence over an extended period of phylogenetic time.", "output": {"entities": {}}, "schema": []}
{"input": "An unusual feature of these replicative genes is that the smaller mRNA begins within a long open reading frame of the larger mRNA.", "output": {"entities": {}}, "schema": []}
{"input": "Different sequence elements of both the retroviral vectors and the c-myc gene recombined during genesis of highly oncogenic retroviruses CMII, MC29, or MH2.", "output": {"entities": {"gene": [{"text": "c-myc gene", "start": 67, "end": 77}]}}, "schema": []}
{"input": "81 milk samples collected from 35 donors 3 days to 7 months after delivery were examined for the occurrence of cytomegalovirus (CMV).", "output": {"entities": {}}, "schema": []}
{"input": "Subcloning of DNA fragments from the 8. 5-kilobase (kb) insert of pAVO4 defined a 4-kb DNA fragment which contained the functional FBP + gene and its regulatory region.", "output": {"entities": {"gene": [{"text": "functional FBP + gene", "start": 120, "end": 141}]}}, "schema": []}
{"input": "Three cases of primary signet-ring cell carcinoma of the rectum are described.", "output": {"entities": {}}, "schema": []}
{"input": "The data obtained up to now only suggest the future potentiality of Bestatin treatment for these types of malignancy.", "output": {"entities": {}}, "schema": []}
{"input": "These data suggest that dopaminergic regulation of adrenal zona glomerulosa corticosteroid and renal renin secretion is absent in patients with high spinal cord transections, suggesting that intact neural pathways from the central nervous system are necessary for metoclopramide stimulation of aldosterone and renin secretion in men.", "output": {"entities": {"gene": [{"text": "renal renin", "start": 95, "end": 106}, {"text": "renin", "start": 310, "end": 315}]}}, "schema": []}
{"input": "In the absence of enhancer sequences, the adenovirus E1A gene can not stimulate CATase synthesis.", "output": {"entities": {"gene": [{"text": "adenovirus E1A gene", "start": 42, "end": 61}, {"text": "CATase", "start": 80, "end": 86}]}}, "schema": []}
{"input": "These IgG antibodies in the babies diminished rapidly after delivery, and were detectable only in 3 cases at 2, 3, and 5 months of ages out of 38 babies up to 21 months.", "output": {"entities": {"gene": [{"text": "IgG antibodies", "start": 6, "end": 20}]}}, "schema": []}
{"input": "Fine analysis at the nucleotide level of the early events in the digestion with nuclease S1 shows that the enzyme attacks preferentially the sequence (G-A) 12 on the message complementary strand.", "output": {"entities": {"gene": [{"text": "nuclease S1", "start": 80, "end": 91}]}}, "schema": []}
{"input": "Those dosages that inhibited mean NTE activity in spinal cord greater than or equal to 72% and brain greater than or equal to 66% of control values within 44 hr postexposure produced marked spinal cord pathology 14 days postexposure in greater than or equal to 90% of similarly dosed animals.", "output": {"entities": {"gene": [{"text": "NTE", "start": 34, "end": 37}]}}, "schema": []}
{"input": "FK 33-824, a methionine-enkephalin analogue, suppressed plasma ACTH to 85% of basal level, while bromocriptine (CB-154) caused no significant change.", "output": {"entities": {"gene": [{"text": "enkephalin", "start": 24, "end": 34}, {"text": "ACTH", "start": 63, "end": 67}]}}, "schema": []}
{"input": "A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.", "output": {"entities": {"gene": [{"text": "v-erbB-related protooncogene", "start": 2, "end": 30}, {"text": "c-erbB-2", "start": 32, "end": 40}, {"text": "c-erbB-1", "start": 63, "end": 71}, {"text": "epidermal growth factor-receptor", "start": 72, "end": 104}]}}, "schema": []}
{"input": "The sequence analysis of both products of individual phi 80 site-specific recombination events in vivo shows that recombination with a secondary attachment (att) site generates several different novel joints at the mismatched position: one recombination event resulted in a single base-pair deletion and two other recombination events resulted in two different single base-pair substitutions.", "output": {"entities": {}}, "schema": []}
{"input": "This L-myc sequence is amplified 10-20-fold in four SCLC cell line DNAs and in one SCLC tumour specimen taken directly from a patient.", "output": {"entities": {"gene": [{"text": "L-myc sequence", "start": 5, "end": 19}]}}, "schema": []}
{"input": "Temperature-shift experiments using synchronously grown cells of a delta top1 top2 temperature-sensitive (ts) double mutant and its isogenic top2 ts strain show that, whereas mitotic blocks can prevent killing of the top2 ts mutant at a nonpermissive temperature, the same treatments are ineffective in preventing cell death of the delta top1 top2 ts double mutant.", "output": {"entities": {"gene": [{"text": "delta top1 top2 temperature-sensitive (ts) double mutant", "start": 67, "end": 123}, {"text": "top2", "start": 141, "end": 145}, {"text": "top2 ts mutant", "start": 217, "end": 231}, {"text": "delta top1 top2 ts double mutant", "start": 332, "end": 364}]}}, "schema": []}
{"input": "The homology to v-mil starts within the coding sequence of exon 1 and ends within the 3' untranslated region of exon 11, 12 nucleotides downstream from the nonsense codon terminating the large open reading frame shared between c-mil and v-mil.", "output": {"entities": {"gene": [{"text": "v-mil", "start": 16, "end": 21}, {"text": "c-mil", "start": 227, "end": 232}, {"text": "v-mil", "start": 237, "end": 242}]}}, "schema": []}
{"input": "Examination of the sequence of the Punta Toro M gene product reveals the presence of multiple hydrophobic sequences including a 19-amino acid, carboxy-proximal, hydrophobic region (G2).", "output": {"entities": {"gene": [{"text": "Punta Toro M gene product", "start": 35, "end": 60}]}}, "schema": []}
{"input": "Six (four FAP; two primary amyloidosis) also had diffusely positive myocardial uptakes, but the intensity was less than that of the sternum.", "output": {"entities": {}}, "schema": []}
{"input": "The intensity of myocardial uptake of Tc-99m-PYP in patients with echocardiographic left ventricular hypertrophy and/or highly refractile myocardial echoes, so-called granular sparkling appearance (GS) was slightly greater than that in patients with neither myocardial hypertrophy nor GS.", "output": {"entities": {}}, "schema": []}
{"input": "Alveolar lymphocytes were surprisingly increased in most patients with AIDS (mean 26. 1 +/-21. 9%; range 1-76%) and CGL (mean 26. 6 +/-22. 6%; range 3-76%) with criteria of activation contrasting with the blood lymphopenia.", "output": {"entities": {}}, "schema": []}
{"input": "We have determined that these nicks occur in both the wild-type and the mutant sites.", "output": {"entities": {}}, "schema": []}
{"input": "The sequence was determined for a 4024-base pair (bp) segment that extends from 149 bp 5' to the cap site of alpha 1 to 207 bp 3' to psi alpha.", "output": {"entities": {"gene": [{"text": "alpha 1", "start": 109, "end": 116}, {"text": "psi alpha", "start": 133, "end": 142}]}}, "schema": []}
{"input": "When phosphorylation of exogenous peptide substrates was measured as a function of receptor self-phosphorylation, tyrosine kinase activity was found to be enhanced two to threefold at 1-2 mol of phosphate per mol of receptor.", "output": {"entities": {"gene": [{"text": "tyrosine kinase", "start": 114, "end": 129}]}}, "schema": []}
{"input": "The pet56 and his3 genes are transcribed divergently from initiation sites that are separated by only 192 bp.", "output": {"entities": {"gene": [{"text": "pet56", "start": 4, "end": 9}, {"text": "his3 genes", "start": 14, "end": 24}]}}, "schema": []}
{"input": "It is concluded that in patients with first-attack genital herpes, the type of HSV is the most important determinant of subsequent recurrences and that intravenous acyclovir has little effect on subsequent recurrences.", "output": {"entities": {}}, "schema": []}
{"input": "Comparison of sequences of ovine and bovine, rat and guinea-pig alpha s1-casein mRNAs has revealed a greater homology in the 3' and especially 5' non coding regions.", "output": {"entities": {"gene": [{"text": "guinea-pig alpha s1-casein mRNAs", "start": 53, "end": 85}]}}, "schema": []}
{"input": "Comparison with a recently described c-sis cDNA clone (Collins et al., Nature 316, 748-750 (1985)) revealed that the 1. 9 kbp DNA region contained a large 5' c-sis exon of at least 1050 bp.", "output": {"entities": {"gene": [{"text": "c-sis cDNA clone", "start": 37, "end": 53}, {"text": "5' c-sis exon", "start": 155, "end": 168}]}}, "schema": []}
{"input": "It was also suggested that the biological activities of 5-FU, ADM and MMC in FAMLIP were stable in FULIP, ADRLIP and MMCLIP.", "output": {"entities": {}}, "schema": []}
{"input": "Surprisingly, a C to G transversion at the first residue of the CAT pentanucleotide, which severely impairs the activity of both promoters, appears to increase affinity of the CAT binding protein.", "output": {"entities": {"gene": [{"text": "CAT pentanucleotide", "start": 64, "end": 83}, {"text": "CAT binding protein", "start": 176, "end": 195}]}}, "schema": []}
{"input": "The nucleotide sequence of 3874 bp of cloned R. sphaeroides chromosomal DNA, including the three structural genes fbcF, fbcB and fbcC has been determined.", "output": {"entities": {"gene": [{"text": "fbcF", "start": 114, "end": 118}, {"text": "fbcB", "start": 120, "end": 124}, {"text": "fbcC", "start": 129, "end": 133}]}}, "schema": []}
{"input": "The N-terminal sequence of one hydrophilic peptide of the FeS protein has been also obtained confirming the fbcF reading frame.", "output": {"entities": {"gene": [{"text": "FeS protein", "start": 58, "end": 69}, {"text": "fbcF", "start": 108, "end": 112}]}}, "schema": []}
{"input": "The 5' and 3' untranslated sequences contain characteristic sequences that are involved in the initiation and termination of transcription, including two possible promoters, one of which may contain two overlapping-10 sequences.", "output": {"entities": {}}, "schema": []}
{"input": "Unlike P135gag-myb-ets and the Mr 75, 000 translation product of c-myb (P75c-myb), which are nuclear proteins, P54c-ets was found to be predominantly cytoplasmic.", "output": {"entities": {"gene": [{"text": "P135gag", "start": 7, "end": 14}, {"text": "myb", "start": 15, "end": 18}, {"text": "ets", "start": 19, "end": 22}, {"text": "c-myb", "start": 65, "end": 70}, {"text": "P75c-myb", "start": 72, "end": 80}, {"text": "P54c-ets", "start": 111, "end": 119}]}}, "schema": []}
{"input": "The Dox-A2 locus is within 3. 4 to 4. 4 kb of the Df (2L) OD15 breakpoint, placing four of the vital loci within a maximum of 15. 5 kb.", "output": {"entities": {"gene": [{"text": "Dox-A2 locus", "start": 4, "end": 16}, {"text": "Df (2L) OD15 breakpoint", "start": 50, "end": 73}]}}, "schema": []}
{"input": "The C-terminal end of this polypeptide harbors three types of repeated sequences.", "output": {"entities": {}}, "schema": []}
{"input": "Further outbreaks of ocular disease in farmed red deer calves caused by HVC-1 were investigated.", "output": {"entities": {}}, "schema": []}
{"input": "From our ultrastructural and biochemical studies, it is evident that Type II pneumocytes are an early target of radiation and the release of surfactant into the alveolus shortly after exposure persists for days and weeks.", "output": {"entities": {}}, "schema": []}
{"input": "Thirty of the clones contained a complete 340 base-pair dimer unit of the repeat.", "output": {"entities": {}}, "schema": []}
{"input": "Two copies of the 72-bp repeat provided efficient activation of gene expression.", "output": {"entities": {}}, "schema": []}
{"input": "The open reading frames of rbsD, rbsA, and rbsC encode proteins of 139, 501, and 321 amino acid residues, respectively.", "output": {"entities": {"gene": [{"text": "rbsD", "start": 27, "end": 31}, {"text": "rbsA", "start": 33, "end": 37}, {"text": "rbsC", "start": 43, "end": 47}]}}, "schema": []}
{"input": "Cattaneo, and J.", "output": {"entities": {}}, "schema": []}
{"input": "Human alpha-galactosidase A: nucleotide sequence of a cDNA clone encoding the mature enzyme.", "output": {"entities": {"gene": [{"text": "Human alpha-galactosidase A", "start": 0, "end": 27}]}}, "schema": []}
{"input": "The amino acid sequence was determined to be residues 716-724 and hence lysine residue 721 is located within the ATP-binding site.", "output": {"entities": {}}, "schema": []}
{"input": "Osteocalcin (and urinary hydroxyproline) were not elevated in isolated hyperphosphatasaemia, indicating that mechanisms other than increased bone turnover may account for the markedly elevated serum alkaline phosphatase activity in these subjects.", "output": {"entities": {"gene": [{"text": "Osteocalcin", "start": 0, "end": 11}, {"text": "serum alkaline phosphatase", "start": 193, "end": 219}]}}, "schema": []}
{"input": "Analysis of glucocorticoid unresponsive cell variants using a mouse glucocorticoid receptor complementary DNA clone.", "output": {"entities": {"gene": [{"text": "mouse glucocorticoid receptor", "start": 62, "end": 91}]}}, "schema": []}
{"input": "Among the v-myc codons, the first 5 are derived from the noncoding 5' terminus of the second c-myc exon, and 412 codons correspond to the c-myc coding region.", "output": {"entities": {"gene": [{"text": "v-myc", "start": 10, "end": 15}, {"text": "c-myc", "start": 93, "end": 98}, {"text": "c-myc", "start": 138, "end": 143}]}}, "schema": []}
{"input": "A recombinant vector, p410 +, was constructed which carried the BamHI-K fragment (nucleotides 107565 to 112625 of the B95-8 strain, encoding the EBV-associated nuclear antigen EBNA-1), the cis-acting sequence from the BamHI-C fragment, and a dominant selectable marker gene encoding G-418 resistance in animal cells.", "output": {"entities": {"gene": [{"text": "BamHI-K fragment", "start": 64, "end": 80}, {"text": "EBNA-1", "start": 176, "end": 182}, {"text": "BamHI-C fragment", "start": 218, "end": 234}]}}, "schema": []}
{"input": "13 men with a history of recurrent genital herpes simplex virus type 2 (HSV-2) infection were followed daily for 4 weeks with samples taken from the urethra for virus isolation.", "output": {"entities": {}}, "schema": []}
{"input": "Next, with carcinoma presenting a leather bottle (linitis plastica type) of the stomach itself, the II c portion of the stomach consisted of fundic glands (undifferentiated carcinoma) shall become the primary focus supporting Nakamura' s theory.", "output": {"entities": {}}, "schema": []}
{"input": "During the biosynthesis of all three mutant polypeptides, the signal peptide is efficiently and accurately cleaved from the nascent protein, even though in mutants X2 and X3 the cleavage site itself has been altered.", "output": {"entities": {}}, "schema": []}
{"input": "The hexanucleotide 5'-TGTCCT-3', thought to be important for GRE activity, not only was found in this sequence and in the 5'-flanking region, but also was present twice in the 3' end of the gene that did not show specific receptor binding.", "output": {"entities": {}}, "schema": []}
{"input": "The smallest of the mini-Mu elements is only 7. 9 kilobase pairs long, allowing the cloning of DNA fragments of up to 31. 1 kilobase pairs, and the largest of them is 21. 7 kilobase pairs, requiring that clones carry insertions of less than 17. 3 kilobase pairs.", "output": {"entities": {}}, "schema": []}
{"input": "The 52-protein subunit of T4 DNA topoisomerase is homologous to the gyrA-protein of gyrase.", "output": {"entities": {"gene": [{"text": "T4 DNA topoisomerase", "start": 26, "end": 46}, {"text": "gyrA-protein", "start": 68, "end": 80}, {"text": "gyrase", "start": 84, "end": 90}]}}, "schema": []}
{"input": "The latent periods from the antral exclusion to the occurrence of anastomotic ulcers after a subtotal gastrectomy with Billroth' s type II reconstruction varied from a few days to 19 years, with an average of 2. 8 years.", "output": {"entities": {}}, "schema": []}
{"input": "The nucleosomal arrays detected by MPE X Fe (II) were characterized by a considerable loss of detail and significantly enhanced accessibility, the extent of which probably reflected the relative transcription rate of each gene.", "output": {"entities": {}}, "schema": []}
{"input": "The molecular weight of in vivo-labeled proteins was increased relative to that of in vitro-translated proteins, indicating that a posttranslational modification had occurred.", "output": {"entities": {}}, "schema": []}
{"input": "Insertion of 4 bp reduced SV40 early promoter-dependent chloramphenicol acetyltransferase (CAT) expression by six-to eightfold.", "output": {"entities": {"gene": [{"text": "SV40 early promoter", "start": 26, "end": 45}, {"text": "chloramphenicol acetyltransferase", "start": 56, "end": 89}, {"text": "CAT", "start": 91, "end": 94}]}}, "schema": []}
{"input": "In the DNAs of all Ph1-positive chronic myelocytic leukemia patients studied to date, a breakpoint on chromosome 22 (the Ph1 chromosome) can be demonstrated with a probe from the bcr (breakpoint cluster region).", "output": {"entities": {"gene": [{"text": "bcr", "start": 179, "end": 182}, {"text": "breakpoint cluster region", "start": 184, "end": 209}]}}, "schema": []}
{"input": "Nuclease footprinting revealed that purified glucocorticoid receptor bound at multiple discrete sites within and at the borders of the tandemly repeated sequence motif that defines Sa.", "output": {"entities": {"gene": [{"text": "glucocorticoid receptor", "start": 45, "end": 68}, {"text": "Sa", "start": 181, "end": 183}]}}, "schema": []}
{"input": "The 96-bp insert contained a termination signal which caused the premature termination of the protein, leading to the generation of a p53 product 9 amino acids shorter than usual.", "output": {"entities": {"gene": [{"text": "p53 product", "start": 134, "end": 145}]}}, "schema": []}
{"input": "All tumors proved histologically to be neuroendocrine in origin.", "output": {"entities": {}}, "schema": []}
{"input": "The coding region of 2385 nucleotides corresponds to a polypeptide chain of 795 amino acids, giving a molecular weight of 91, 555 for the hsp108 protein.", "output": {"entities": {"gene": [{"text": "hsp108 protein", "start": 138, "end": 152}]}}, "schema": []}
{"input": "Transcriptional control signals of a herpes simplex virus type 1 late (gamma 2) gene lie within bases-34 to + 124 relative to the 5' terminus of the mRNA.", "output": {"entities": {"gene": [{"text": "herpes simplex virus type 1 late (gamma 2) gene", "start": 37, "end": 84}]}}, "schema": []}
{"input": "A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps.", "output": {"entities": {"gene": [{"text": "cytoplasmic protein-tyrosine kinases", "start": 38, "end": 74}, {"text": "Fujinami sarcoma virus P130gag", "start": 133, "end": 163}, {"text": "fps", "start": 164, "end": 167}]}}, "schema": []}
{"input": "Gluzman, EMBO J.", "output": {"entities": {}}, "schema": []}
{"input": "A single exon encodes the carboxyl-terminal 26 amino acids of the ssd chain and the 3' untranslated region of its mRNA, ending with a poly (A)-addition site.", "output": {"entities": {"gene": [{"text": "ssd chain", "start": 66, "end": 75}]}}, "schema": []}
{"input": "The 5'-nontranslated sequences and parts of the coding sequences of various yeast genes have been cloned into representative lacZ fusion vectors.", "output": {"entities": {"gene": [{"text": "lacZ", "start": 125, "end": 129}]}}, "schema": []}
{"input": "Two activities of the D protein of the miniF plasmid have been found.", "output": {"entities": {"gene": [{"text": "D protein", "start": 22, "end": 31}]}}, "schema": []}
{"input": "SPECT examination of the TMJ using 99m Tc-MDP was performed in 43 patients with arthrographically proven anterior dislocation of the disc and in 30 normals.", "output": {"entities": {}}, "schema": []}
{"input": "Plasma renin activity rose and the plasma aldosterone level fell after taking lisinopril.", "output": {"entities": {"gene": [{"text": "Plasma renin", "start": 0, "end": 12}]}}, "schema": []}
{"input": "The second group of homologous elements is present in the upstream region of both genes.", "output": {"entities": {}}, "schema": []}
{"input": "Constitutive function of a positively regulated promoter reveals new sequences essential for activity.", "output": {"entities": {}}, "schema": []}
{"input": "We inserted genes or gene segments, that code for the bacterial chloramphenicol acetyltransferase, the bacterial gene conferring resistance against hygromycin, and the ORF E7 of the human papillomavirus type 18 into these vectors.", "output": {"entities": {"gene": [{"text": "bacterial chloramphenicol acetyltransferase", "start": 54, "end": 97}, {"text": "E7", "start": 172, "end": 174}]}}, "schema": []}
{"input": "By contrast, their basal adrenal androgen levels were significantly decreased compared to those in normal subjects on both the day on and the day off prednisone (P less than 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat.", "output": {"entities": {}}, "schema": []}
{"input": "During pentobarbital anesthesia, the basal VO2 was 5. 26 ml/kg/min and was increased by epinephrine in a dose dependent manner at plasma concentrations between 3. 9 ng/ml (VO2 = 5. 68 ml/kg/min) and 36. 5 ng/ml (VO2 = 6. 47 ml/kg/min).", "output": {"entities": {}}, "schema": []}
{"input": "Oligonucleotide-directed mutagenesis was used to create an NdeI restriction site at the natural ATG of the yeast R.", "output": {"entities": {"gene": [{"text": "NdeI restriction site", "start": 59, "end": 80}]}}, "schema": []}
{"input": "ACTH release is transiently suppressed in some children after exogenous ACTH treatment.", "output": {"entities": {"gene": [{"text": "ACTH", "start": 0, "end": 4}, {"text": "ACTH", "start": 72, "end": 76}]}}, "schema": []}
{"input": "We previously showed that the upstream promoter element of the yeast RP39A gene consists of these identical sequence motifs.", "output": {"entities": {"gene": [{"text": "yeast RP39A gene", "start": 63, "end": 79}]}}, "schema": []}
{"input": "These data suggest that mammalian erythroid alpha-spectrin evolved by duplication and rapid divergence from an ancestral alpha-fodrin-like gene.", "output": {"entities": {"gene": [{"text": "alpha-spectrin", "start": 44, "end": 58}, {"text": "alpha-fodrin-like gene", "start": 121, "end": 143}]}}, "schema": []}
{"input": "One group of six cDNA clones was derived from a 2. 9-kilobase early transcript encoded by the IR2 repeat element and showed restriction site polymorphism for the enzyme SmaI.", "output": {"entities": {"gene": [{"text": "enzyme SmaI", "start": 162, "end": 173}]}}, "schema": []}
{"input": "Combined immunochemotherapy with cyclophosphamide plus BCG gave a better enhancement of the antitumor effect of the cytostatic than that of the combination of methotrexate plus BCG and cyclophosphamide plus levamisole.", "output": {"entities": {}}, "schema": []}
{"input": "Indeed, A-MuLV pseudotyped with some viruses, such as the Moloney MuLV, has been shown to be highly lymphogenic, whereas A-MuLV pseudotyped with other viruses, such as the BALB/c endogenous N-tropic MuLV, has been shown to be devoid of lymphogenic potential (N.", "output": {"entities": {}}, "schema": []}
{"input": "The presence of circulating platelet aggregates and elevated levels of fibrinopeptide A (a cleavage product of fibrin) suggests that platelet activation and fibrin deposition may play a role in the pathogenesis of this disorder.", "output": {"entities": {"gene": [{"text": "fibrinopeptide A", "start": 71, "end": 87}, {"text": "fibrin", "start": 111, "end": 117}, {"text": "fibrin", "start": 157, "end": 163}]}}, "schema": []}
{"input": "4.", "output": {"entities": {}}, "schema": []}
{"input": "In general, the values obtained by the two methods were in agreement for each species of epidermal growth factor and followed the order: wild type greater than Glu24----Gly greater than Asp27----Gly much greater than Pro7----Thr greater than Tyr29----Gly greater than Leu47----His.", "output": {"entities": {"gene": [{"text": "epidermal growth factor", "start": 89, "end": 112}]}}, "schema": []}
{"input": "It is concluded that suppression of elevated prolactin levels in progressive metastatic breast cancer patients is not effective in restoring tumor sensitivity to chemotherapy.", "output": {"entities": {"gene": [{"text": "prolactin", "start": 45, "end": 54}]}}, "schema": []}
{"input": "We report a prevalence study of the best visual acuity in the affected eye of 100 selected patients with herpetic keratitis seen during a two-year period.", "output": {"entities": {}}, "schema": []}
{"input": "We also found an eIF-4A intronless retroposon which, when compared to the cDNA, contains a single nucleotide difference.", "output": {"entities": {"gene": [{"text": "eIF-4A", "start": 17, "end": 23}]}}, "schema": []}
{"input": "After infection of 293 cells (which provide complementary E1a-E1b functions), both viruses directed equal amounts of P/C-specific mRNA transcription.", "output": {"entities": {"gene": [{"text": "E1a", "start": 58, "end": 61}, {"text": "E1b", "start": 62, "end": 65}, {"text": "P/C-specific mRNA", "start": 117, "end": 134}]}}, "schema": []}
{"input": "This observation cannot be explained by the scanning model for ribosomal initiation and suggests that ribosomes may be binding directly at an internal mRNA site at or near the initiator AUG codon for the C protein.", "output": {"entities": {"gene": [{"text": "C protein", "start": 204, "end": 213}]}}, "schema": []}
{"input": "In view of these results, simultaneous pancreas-kidney transplantation appears to be the treatment of choice for Type I diabetic patients.", "output": {"entities": {}}, "schema": []}
{"input": "This makes these compounds attractive as vehicles for these and other gases in-vivo and in-vitro.", "output": {"entities": {}}, "schema": []}
{"input": "DNA sequencing of the DPM1 gene revealed an open reading frame of 801 bases.", "output": {"entities": {"gene": [{"text": "DPM1 gene", "start": 22, "end": 31}]}}, "schema": []}
{"input": "The relationship between primary malignant lymphoma of the thyroid and chronic thyroiditis is discussed.", "output": {"entities": {}}, "schema": []}
{"input": "Administration of anticoagulants, i. e., heparin, prostaglandin E1 and ticlopidine seems to be effective in alleviating symptoms and might prevent further deterioration.", "output": {"entities": {}}, "schema": []}
{"input": "Mutational analysis of the L1 binding site of 23S rRNA in Escherichia coli.", "output": {"entities": {"gene": [{"text": "L1 binding site", "start": 27, "end": 42}, {"text": "23S rRNA in Escherichia coli", "start": 46, "end": 74}]}}, "schema": []}
{"input": "Animals may be immunized by oral vaccination, but natural mechanisms that also can terminate outbreaks are discussed.", "output": {"entities": {}}, "schema": []}
{"input": "Prostacyclin formation, reflected by the excretion rate of its stable metabolite 6-keto-prostaglandin F1 alpha, was measured by means of radioimmunoassay in 4-hour urine specimens obtained during a smoking-free period and after participants had inhaled smoke from four high-nicotine cigarettes.", "output": {"entities": {}}, "schema": []}
{"input": "However, excretion of 6-keto-prostaglandin F1 alpha was further reduced in the smokers who used oral contraceptives (133 +/-20 to 86 +/-9 ng/gm of creatinine, p less than 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "The in vitro activity of mecillinam and amoxicillin/clavulanic acid against Escherichia coli strains producing beta-lactamases of the TEM-1, Oxa-1 and chromosomal type were studied using the broth and agar dilution technique.", "output": {"entities": {"gene": [{"text": "beta-lactamases", "start": 111, "end": 126}, {"text": "TEM-1", "start": 134, "end": 139}, {"text": "Oxa-1", "start": 141, "end": 146}]}}, "schema": []}
{"input": "GCN4 encodes a transcriptional activator of amino acid biosynthetic genes in Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "GCN4", "start": 0, "end": 4}]}}, "schema": []}
{"input": "These results imply that the GCN3 product can promote either repression or activation of GCN4 expression depending on amino acid availability.", "output": {"entities": {"gene": [{"text": "GCN3 product", "start": 29, "end": 41}, {"text": "GCN4", "start": 89, "end": 93}]}}, "schema": []}
{"input": "The efficacy of these immunosuppressive drugs is clinical proven.", "output": {"entities": {}}, "schema": []}
{"input": "The amino acid sequence of the S. aureus peptide carrying the phosphoryl group was found to be Gln-Val-Val-Ser-Thr-Phe-Met-Gly-Asn-Gly-Leu-Ala-Ile-Pro-His-Gly-Thr-Asp-Asp.", "output": {"entities": {}}, "schema": []}
{"input": "These mutations alter two regions of GAL4 protein: the DNA binding domain, and the transcription activation domain.", "output": {"entities": {"gene": [{"text": "GAL4 protein", "start": 37, "end": 49}]}}, "schema": []}
{"input": "The results indicated that two genes (citA and citB) have separate promoters, and the location of the promoter for the citB gene in the Tn3411 nucleotide sequence was different from that in pMS185.", "output": {"entities": {"gene": [{"text": "citA", "start": 38, "end": 42}, {"text": "citB", "start": 47, "end": 51}, {"text": "citB gene", "start": 119, "end": 128}, {"text": "Tn3411", "start": 136, "end": 142}]}}, "schema": []}
{"input": "The rci gene was fused with lacZ and its gene product was identified by Western blot analysis.", "output": {"entities": {"gene": [{"text": "rci gene", "start": 4, "end": 12}, {"text": "lacZ", "start": 28, "end": 32}]}}, "schema": []}
{"input": "Structure and regulation of a nuclear gene in Saccharomyces cerevisiae that specifies MRP13, a protein of the small subunit of the mitochondrial ribosome.", "output": {"entities": {"gene": [{"text": "MRP13", "start": 86, "end": 91}]}}, "schema": []}
{"input": "After a survey of the anatomical and physiological basis of operative treatment of behaviour disorders by stereotactic lesions in the amygdala and the posterior medial hypothalamus the author describes his own experiences with 603 operations for control of conservatively untreatable aggressiveness.", "output": {"entities": {}}, "schema": []}
{"input": "Although large epidemiologic studies are best able to identify the relative contributions of specific risk factors while controlling for other risk factors, new studies need to focus on important unresolved questions.", "output": {"entities": {}}, "schema": []}
{"input": "The amino acid sequences of the yeast and mammalian mitochondrial targeting sequences are similar but less related than the mature polypeptides.", "output": {"entities": {}}, "schema": []}
{"input": "During insulin infusion, a 20% dextrose solution was infused by a Biostator in order to maintain the patient' s glycemia at 90 mg/dl.", "output": {"entities": {"gene": [{"text": "insulin", "start": 7, "end": 14}]}}, "schema": []}
{"input": "Amounts of glucose infused during the last 20 min of each 2 hour insulin infusion were (at 1 and 10 m/kg/min respectively): before treatment (K + = 2. 7 mmol/l): 2. 4 and 8. 4 mg/kg/min; after spironolactone (K + = 3. 9 mmol/l): 3. 3 and 15. 4 mg/kg/min; after indomethacine (K + = 3. 7 mmol/l): 5 and 19 mg/kg/min after stopping drugs (K + = 2. 9 mmol/l): 2. 5 and 5. 3 mg/kg/min.", "output": {"entities": {"gene": [{"text": "insulin", "start": 65, "end": 72}]}}, "schema": []}
{"input": "Mycobacterium avium-intracellulare complex infections in the acquired immunodeficiency syndrome.", "output": {"entities": {}}, "schema": []}
{"input": "Recurrence of oxalate deposition in a renal transplant during ciclosporin A therapy.", "output": {"entities": {}}, "schema": []}
{"input": "The bile acid sequestrants (cholestyramine and colestipol), nicotinic acid, fenofibrate and inhibitors of hydroxymethylglutaryl coenzyme A (HMG CoA) reductase (e. g. lovastatin or simvastatin) are the most effective drugs for use in patients with primary hypercholesterolaemia; these agents reduce plasma concentrations of total and LDL-cholesterol by 15 to 45%.", "output": {"entities": {"gene": [{"text": "hydroxymethylglutaryl coenzyme A (HMG CoA) reductase", "start": 106, "end": 158}, {"text": "LDL-cholesterol", "start": 333, "end": 348}]}}, "schema": []}
{"input": "Finally, the pathophysiological aspects of urinary acidification are discussed, focusing on renal tubular acidosis models (induced by maleate and amphotericin B treatment) and their cellular mechanisms, as well as the role of adrenal steroids in urinary acidification.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis in 3 groups of patients suffering from simple acute and pernicious malarial flare-ups", "output": {"entities": {}}, "schema": []}
{"input": "Statement on the development of guidelines for the prevention of AIDS transmission in the workplace.", "output": {"entities": {}}, "schema": []}
{"input": "Modifications of the involuntary postcontraction in diseased people.", "output": {"entities": {}}, "schema": []}
{"input": "Cocaine-treated rats acquired a preference for cocaine-associated contextual stimuli (CS) relative to saline-injected control rats.", "output": {"entities": {}}, "schema": []}
{"input": "Under these schedules, a reinforced response run consisted of responding between eight and 12 times on one response key (work key) and then responding once on a second response key (reinforced key).", "output": {"entities": {}}, "schema": []}
{"input": "Intravenous glucose tolerance tests were performed before operation, before starting CyA and after 3 weeks.", "output": {"entities": {}}, "schema": []}
{"input": "The effects of glutaraldehyde on dimensions and ultrastructure of microvascular beds in rat mesentery were studied in two kinds of experiment, administering the fixative by intra-arterial perfusion at a pressure of 80 mm Hg and by superfusion of the exteriorized mesenteric membrane.", "output": {"entities": {}}, "schema": []}
{"input": "This gave rise to RNA molecules with 3'-untranslated regions of roughly 375, 655, and 945 base pairs.", "output": {"entities": {}}, "schema": []}
{"input": "Also, the BALB/c gene contains a single substitution in a conserved octamer sequence approximately equal to 100 nucleotides upstream of the coding region, which could affect its expression.", "output": {"entities": {"gene": [{"text": "BALB/c gene", "start": 10, "end": 21}]}}, "schema": []}
{"input": "Our data suggest that it may be possible to individualize hCG administration at midcycle by determining the number of follicles greater than 1 cm by ultrasound on cycle day 12 or 13 and giving hCG when serum E2 levels reach 1100 to 1200 pmol/l per follicle.", "output": {"entities": {"gene": [{"text": "hCG", "start": 58, "end": 61}, {"text": "hCG", "start": 193, "end": 196}]}}, "schema": []}
{"input": "Within Stage IA, 141 patients had well differentiated tumor (G1), 20 had moderately well differentiated tumor (G2), and 12 patients had poorly differentiated (G3).", "output": {"entities": {}}, "schema": []}
{"input": "Mechanism of the t (14; 18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners.", "output": {"entities": {}}, "schema": []}
{"input": "After age 30, mean hemoglobin levels for men gradually declined, while those in women rose, so that the sex difference diminished after 60 years of age.", "output": {"entities": {"gene": [{"text": "hemoglobin", "start": 19, "end": 29}]}}, "schema": []}
{"input": "Ritanserin is a new substance with highly selective blocking activity on S2 receptors for 5-HT in the central nervous system.", "output": {"entities": {"gene": [{"text": "S2 receptors", "start": 73, "end": 85}]}}, "schema": []}
{"input": "Ethylene glycol and diethylene glycol were each administered once weekly subcutaneously to groups of 100 female NMRI mice at 3 dosages (30; 10 und 3 mg single dose per mouse).", "output": {"entities": {}}, "schema": []}
{"input": "Research on ethylene glycol and diethylene glycol for carcinogenic effects", "output": {"entities": {}}, "schema": []}
{"input": "The results suggest that the greater estrogenic influence associated with the ethinyl estradiol-containing OC resulted in inhibition of coronary artery atherosclerosis despite a pronounced progestin-induced lowering of plasma HDL cholesterol concentration and, further, that hormonal balance may have a marked influence on the relationship between plasma lipids and atherogenesis.", "output": {"entities": {"gene": [{"text": "HDL cholesterol", "start": 226, "end": 241}]}}, "schema": []}
{"input": "During BH the ventilator was disconnected and a bias flow of 50% O2 at 4-5 l/min was delivered through the side ports of a small catheter whose tip was positioned 1 cm cephalad of the carina.", "output": {"entities": {}}, "schema": []}
{"input": "Comparison of beta 2-microglobulin removal using the same polysulphone membrane for haemodialysis and haemofiltration shows that beta 2-microglobulin is more effectively removed by convection than by diffusion when both treatment modes are matched for blood flow and urea clearance.", "output": {"entities": {"gene": [{"text": "beta 2-microglobulin", "start": 14, "end": 34}, {"text": "beta 2-microglobulin", "start": 129, "end": 149}]}}, "schema": []}
{"input": "40. 3 +/-10. 1 mg/l (SD) vs 31. 2 +/-8. 0, P less than 0. 01). beta 2m was not significantly higher in patients with bone cysts (37. 7 +/-11. 4 mg/l vs 37. 0 +/-10. 0), but median duration of dialysis was significantly (P less than 0. 01) longer in patients with bone cysts (90 vs 57 months). beta 2m was lower in patients maintained on dialysis for less than 1 year and whose residual urine volume was greater than 0. 1 litre per day.", "output": {"entities": {"gene": [{"text": "beta 2m", "start": 63, "end": 70}, {"text": "beta 2m", "start": 293, "end": 300}]}}, "schema": []}
{"input": "The mean percentage of linoleic acid in the triglycerides of the subcutaneous adipose tissue (PLASAT) of these subjects was substantially higher than that in a similar group examined in 1975-1976.", "output": {"entities": {}}, "schema": []}
{"input": "In overdoses up to 2 g fluvoxamine no lasting toxic effects were observed.", "output": {"entities": {}}, "schema": []}
{"input": "It is concluded that the plasma prolactin response to 12. 5 micrograms i. v.", "output": {"entities": {"gene": [{"text": "plasma prolactin", "start": 25, "end": 41}]}}, "schema": []}
{"input": "The remaining six patients had slightly decreased (n = 3) or normal (n = 3) seminal parameters.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, a wild-type strain containing a temperature-sensitive threonyl-tRNA synthetase mutation showed increased thr operon expression at the non-permissive temperature, whereas none of the mutants showed any change.", "output": {"entities": {"gene": [{"text": "temperature-sensitive threonyl-tRNA synthetase mutation", "start": 45, "end": 100}, {"text": "thr operon", "start": 118, "end": 128}]}}, "schema": []}
{"input": "Significant treatment-related problems appeared during the second decade in 5 patients, including one chest wall sarcoma; all of these patients had received at least 60 Gy to breast and regional nodal areas.", "output": {"entities": {}}, "schema": []}
{"input": "Of 7 patients treated with cyclophosphamide, hexamethylmelamine, adriamycin and cisplatin (CHAP-5), 6 had measurable disease, of whom 5 yielded a response (2 complete responses for 19 + and 40 months and 3 partial responses for 4, 7 and 8 months).", "output": {"entities": {}}, "schema": []}
{"input": "Isolation and characterization of a vinculin cDNA from chick-embryo fibroblasts.", "output": {"entities": {"gene": [{"text": "vinculin cDNA from chick-embryo fibroblasts", "start": 36, "end": 79}]}}, "schema": []}
{"input": "A complementary study, showing a good agreement between surface and oesophageal EMGd seems to confirm that surface EMGd is a useful and promising tool for clinical investigation.", "output": {"entities": {}}, "schema": []}
{"input": "No differences in fixation quality were observed between cochleas fixed by intravascular perfusion and cochleas fixed by intralabyrinthine perfusion.", "output": {"entities": {}}, "schema": []}
{"input": "The DNA sequence encodes a protein of 1520 amino acids with sequence homology to the human c-abl proto-oncogene product, beginning at the amino terminus and extending 656 amino acids through the region essential for tyrosine kinase activity.", "output": {"entities": {"gene": [{"text": "human c-abl proto-oncogene product", "start": 85, "end": 119}, {"text": "tyrosine kinase", "start": 216, "end": 231}]}}, "schema": []}
{"input": "The requirement of different essential fatty acids in patients with total parenteral nutrition after heavy injury is of special interest with respect to the development and prognosis of shock, sepsis or adult respiratory distress syndrome.", "output": {"entities": {}}, "schema": []}
{"input": "The Drosophila melanogaster Gart gene encodes three enzymatic activities in the pathway for purine de novo synthesis.", "output": {"entities": {"gene": [{"text": "Drosophila melanogaster Gart gene", "start": 4, "end": 37}]}}, "schema": []}
{"input": "The role of neuroplasticity in the response to drugs.", "output": {"entities": {}}, "schema": []}
{"input": "Biol.", "output": {"entities": {}}, "schema": []}
{"input": "The heart rate, respiratory rate, arterial O2 and systemic vascular resistance were not significantly altered.", "output": {"entities": {}}, "schema": []}
{"input": "Human rIL-3 expressed in COS7 cells has multipotential CSF activity in semisolid cultures of bone marrow cells, and selectively induced the proliferation of My-10 + marrow or cord blood cells in liquid cultures.", "output": {"entities": {"gene": [{"text": "Human rIL-3", "start": 0, "end": 11}, {"text": "CSF", "start": 55, "end": 58}]}}, "schema": []}
{"input": "In 14 patients whose PaCO2 was greater than or equal to 39 torr (range 39 to 58 torr) and clinical asthma score was 6 or greater, PaCO2 decreased a mean of 11. 7 torr during a mean of 8. 1 hours.", "output": {"entities": {}}, "schema": []}
{"input": "A randomized, prospective study was conducted to compare ovarian stimulation with human menopausal gonadotropin (hMG) and human follicle-stimulating hormone (hFSH) in an in vitro fertilization and embryo transfer (IVF-ET) program.", "output": {"entities": {"gene": [{"text": "human menopausal gonadotropin", "start": 82, "end": 111}, {"text": "hMG", "start": 113, "end": 116}, {"text": "human follicle-stimulating hormone", "start": 122, "end": 156}, {"text": "hFSH", "start": 158, "end": 162}]}}, "schema": []}
{"input": "Our findings suggest that the mtr product causes both transcription attenuation and inhibition of translation of trpE mRNA.", "output": {"entities": {"gene": [{"text": "mtr product", "start": 30, "end": 41}, {"text": "trpE mRNA", "start": 113, "end": 122}]}}, "schema": []}
{"input": "Apropos of a case", "output": {"entities": {}}, "schema": []}
{"input": "A prostaglandin analogue given in early pregnancy and human chorionic gonadotropin given near the end of the ensuing follicular phase were used for controlling the reproductive cycle, timing oocyte collection, and synchronizing the cycles of oocyte donors and embryo recipients.", "output": {"entities": {"gene": [{"text": "human chorionic gonadotropin", "start": 54, "end": 82}]}}, "schema": []}
{"input": "The nucleolin gene extends over 9000 base-pairs and is split into 14 exons that encode the 706 amino acid residues of the protein.", "output": {"entities": {"gene": [{"text": "nucleolin gene", "start": 4, "end": 18}]}}, "schema": []}
{"input": "Although L-threo-dihydroxyphenylserine (DOPS), an artificial norepinephrine (NE) precursor, did not change immobility in intact mice, DOPS significantly reduced immobility in mice pretreated with the selective NE neurotoxin DSP4.", "output": {"entities": {}}, "schema": []}
{"input": "Substantial amounts of liposomal ampicillin were recovered from isolated Kupffer cells, the target cells of L. monocytogenes after intravenous inoculation.", "output": {"entities": {}}, "schema": []}
{"input": "This suggested that delta 6 and delta 5 desaturation activities are normal in these conditions with this C18: 2w6 supply.", "output": {"entities": {}}, "schema": []}
{"input": "Here we report the complete 6-kilobase cDNA sequence coding for a chain of 1775 amino acids, as well as the genomic structure.", "output": {"entities": {}}, "schema": []}
{"input": "HDL-cholesterol (+ 6%, P less than. 01) and apolipoprotein A-I (+ 6%, P less than. 01) concentrations increased significantly only in the young.", "output": {"entities": {"gene": [{"text": "HDL-cholesterol", "start": 0, "end": 15}, {"text": "apolipoprotein A-I", "start": 44, "end": 62}]}}, "schema": []}
{"input": "The Euglena ribosomal protein gene cluster resembles the S-10 ribosomal protein operon of Escherichia coli in gene organization and follows the exact linear order of the analogous genes in the tobacco and liverwort chloroplast genomes.", "output": {"entities": {"gene": [{"text": "Euglena ribosomal protein gene cluster", "start": 4, "end": 42}, {"text": "S-10 ribosomal protein operon of Escherichia coli", "start": 57, "end": 106}]}}, "schema": []}
{"input": "The distribution of the sites of recombinational resolution is inversely correlated with that of the gradient of sequence divergence, with only approximately 7% of the X recombinants resolved within the 3' third of the X blocks where two diverged Alu family repeats reside.", "output": {"entities": {"gene": [{"text": "Alu", "start": 247, "end": 250}]}}, "schema": []}
{"input": "The nucleotide sequence of the region upstream from M. voltae ORFtrpA was determined and revealed the presence of an ORF of 1227 nucleotides (ORFtrpB) encoding a 409 amino acid polypeptide of mol. wt.", "output": {"entities": {"gene": [{"text": "M. voltae ORFtrpA", "start": 52, "end": 69}, {"text": "ORFtrpB", "start": 142, "end": 149}]}}, "schema": []}
{"input": "Of 49 receptors which fired in phase with ventilation, 13 behaved like mammalian rapidly adapting pulmonary stretch receptors, 19 like mammalian slowly adapting pulmonary stretch receptors (PSR), and 17 like avian intrapulmonary CO2-sensitive chemoreceptors (IPC).", "output": {"entities": {}}, "schema": []}
{"input": "Symptomatic hyperventilators had a larger number of sighs and abnormally wide fluctuations in baseline for inspiratory time, expiratory time, and PETCO2.", "output": {"entities": {}}, "schema": []}
{"input": "In the IA task, post-training intraperitoneal injections of picrotoxin and bicuculline induced a dose-dependent enhancement of retention measured 24 h after the training, while retention was not affected by bicuculline methiodide (a GABA receptor antagonist that does not readily cross the blood-brain barrier).", "output": {"entities": {"gene": [{"text": "GABA receptor", "start": 233, "end": 246}]}}, "schema": []}
{"input": "Clinical research of non-A, non-B post-transfusion hepatitis", "output": {"entities": {}}, "schema": []}
{"input": "It is suggested that the use of endogenous creatinine clearance to estimate the glomerular filtration rate (GFR) requires caution and the recognition of the limitations of the method, and that simpler techniques (serum creatinine or estimated endogenous creatinine clearance) are preferable in routine practice.", "output": {"entities": {}}, "schema": []}
{"input": "The protein mixtures of sesame flour and soybean flour were well accepted.", "output": {"entities": {}}, "schema": []}
{"input": "The 5' end of the coding region was located precisely by comparing the deduced amino acid sequence to the actual N-terminal amino acid sequence of IHF.", "output": {"entities": {"gene": [{"text": "IHF", "start": 147, "end": 150}]}}, "schema": []}
{"input": "A protein footprint also was identified for a GC box element at nucleotides-59 to-45.", "output": {"entities": {}}, "schema": []}
{"input": "Insulin-like growth factor II (IGFII) is a mitogenic polypeptide, the mRNAs of which are present in multiple forms, despite derivation from a single gene.", "output": {"entities": {"gene": [{"text": "Insulin-like growth factor II", "start": 0, "end": 29}, {"text": "IGFII", "start": 31, "end": 36}]}}, "schema": []}
{"input": "The central visual fields of 2165 normal and 106 glaucoma eyes were measured using a threshold related suprathreshold strategy.", "output": {"entities": {}}, "schema": []}
{"input": "Effect of chronic undernutrition on susceptibility to cold stress in young adult and aged rats.", "output": {"entities": {}}, "schema": []}
{"input": "This effect and the fact that all three doses were toxic to the dams dictated that a second experiment be carried out at lower doses.", "output": {"entities": {}}, "schema": []}
{"input": "The CHARGE association is a collection of multisystem congenital anomalies including choanal atresia.", "output": {"entities": {}}, "schema": []}
{"input": "Esophageal brush cytological screening was undertaken and blood concentrations of micronutrients (vitamin A, E, B12, folic acid and methionine) determined from adults at risk for esophageal carcinoma (EC) in Transkei and Ciskei, Southern Africa.", "output": {"entities": {}}, "schema": []}
{"input": "Aviators from the Light Attack Wing, Pacific were surveyed and the results were categorized by aircraft type.", "output": {"entities": {}}, "schema": []}
{"input": "Evaluation of human and bovine modified-hemoglobin solution as oxygen-carrying fluid for blood volume replacement.", "output": {"entities": {"gene": [{"text": "hemoglobin", "start": 40, "end": 50}]}}, "schema": []}
{"input": "Delayed gallbladder visualization and reduction in ejection fraction were sensitive but nonspecific indicators of biliary disease.", "output": {"entities": {}}, "schema": []}
{"input": "26 micrograms PAF or placebo was sprayed into each nasal cavity 8 h and 1 h before a nasal allergen challenge.", "output": {"entities": {"gene": [{"text": "PAF", "start": 14, "end": 17}]}}, "schema": []}
{"input": "Sci.", "output": {"entities": {}}, "schema": []}
{"input": "Chem.", "output": {"entities": {}}, "schema": []}
{"input": "Sequential MR examinations of the nasal cavity and paranasal sinuses were performed within a 6-8 h period in five normal volunteers.", "output": {"entities": {}}, "schema": []}
{"input": "Comparison was made with other neuroradiological imaging modalities including CT, myelography, CT ventriculography, and CT myelocisternography.", "output": {"entities": {}}, "schema": []}
{"input": "The feed given to young broiler chickens was contaminated artificially with Salmonella kedougou, a serotype associated with both subclinical infections in commercially reared chickens and food poisoning in humans.", "output": {"entities": {}}, "schema": []}
{"input": "A poor correlation was found between a mildly-atypical (inflammatory) cytological result (class 2) and a benign histological diagnosis: 48% of class-2 smears were diagnosed histologically as dysplasia or worse.", "output": {"entities": {}}, "schema": []}
{"input": "Change in plasma cystyl aminopeptidase (oxytocinase) between 30-34 weeks' gestation as a predictor of pregnancy-induced hypertension.", "output": {"entities": {"gene": [{"text": "plasma cystyl aminopeptidase", "start": 10, "end": 38}, {"text": "oxytocinase", "start": 40, "end": 51}]}}, "schema": []}
{"input": "The test for alpha-naphthyl esterase and quantitation of macrophages (absolute number) per infiltration area unit adjacent to the abscess suggest a direct correlation between the absolute number of macrophages and the width of the capsule.", "output": {"entities": {"gene": [{"text": "alpha-naphthyl esterase", "start": 13, "end": 36}]}}, "schema": []}
{"input": "Determined as migration differentials, chemotactic and chemokinetic responsiveness tended to be higher in the neutropenic group.", "output": {"entities": {}}, "schema": []}
{"input": "The deduced 96-residue amino acid coding sequence of the murine HMG-I (Y) cDNA is very similar to the reported amino acid sequence of human HMG-I, except that it lacks 11 internal amino acids reported in the human protein.", "output": {"entities": {"gene": [{"text": "HMG-I (Y)", "start": 64, "end": 73}, {"text": "HMG-I", "start": 140, "end": 145}]}}, "schema": []}
{"input": "Interpersonal style differences among drug abusers were explored using Ryan' s (1977) typological system of FIRO-B interpretation.", "output": {"entities": {}}, "schema": []}
{"input": "Statement of the American Academy of Implant Dentistry.", "output": {"entities": {}}, "schema": []}
{"input": "Sera from euthyroid post-menopausal or pregnant women yielded TSH levels within the normal range.", "output": {"entities": {"gene": [{"text": "TSH", "start": 62, "end": 65}]}}, "schema": []}
{"input": "No UOxase mRNA was detected in 11 nonhepatic tissues of rat, suggesting tissue specificity of expression of this UOxase gene.", "output": {"entities": {"gene": [{"text": "UOxase mRNA", "start": 3, "end": 14}, {"text": "UOxase gene", "start": 113, "end": 124}]}}, "schema": []}
{"input": "The platelet adhesion rate on these layers were tested concerning the valuation of the haemocompatibility of the basic-polymers polyurethane (PUR), polyvinylchloride (PVC), and polystyrene (PS) in two different worked test chambers.", "output": {"entities": {}}, "schema": []}
{"input": "In a 112-d feedlot trial, 105 heifers were assigned to light, medium and heavy weight blocks on five treatments: dietary MGA (. 5 mg. hd-1. d-1), control (no MGA) or DEPO-MGA on d 1 at. 5, 1. 0 or 1. 5 ml/hd (30, 60 or 90 mg MGA/hd, respectively).", "output": {"entities": {}}, "schema": []}
{"input": "Existence and uniqueness of solutions of the appropriate boundary value problems are established, in the case of small permeability coefficients and transport rates, or large diffusion coefficients and small resistance to flow constants.", "output": {"entities": {}}, "schema": []}
{"input": "There were gene clusters encoding photosynthesis components such as the psbB-psbH-petB-petD and the psbE-psbF clusters.", "output": {"entities": {"gene": [{"text": "psbB", "start": 72, "end": 76}, {"text": "psbH", "start": 77, "end": 81}, {"text": "petB", "start": 82, "end": 86}, {"text": "petD", "start": 87, "end": 91}]}}, "schema": []}
{"input": "The partial sequence of the 62-kDa nuclear pore glycoprotein shows little similarity to other characterized proteins and elucidates structural features of a member of the family of nuclear pore glycoproteins.", "output": {"entities": {"gene": [{"text": "62-kDa nuclear pore glycoprotein", "start": 28, "end": 60}, {"text": "nuclear pore glycoproteins", "start": 181, "end": 207}]}}, "schema": []}
{"input": "Seventy-two hours after administration of vitamin K1, plasma concentrations of the vitamin were not different from normal.", "output": {"entities": {}}, "schema": []}
{"input": "The glomerular filtration rate did not change but lithium clearance fell by 30%.", "output": {"entities": {}}, "schema": []}
{"input": "The pathogenesis of Dupuytren' s contracture", "output": {"entities": {}}, "schema": []}
{"input": "An ELISA procedure was developed for monitoring the specific IgE response in dogs to Dirofilaria immitis infection.", "output": {"entities": {"gene": [{"text": "IgE", "start": 61, "end": 64}]}}, "schema": []}
{"input": "Fifty min after release from stress, increases in plasma corticosterone levels induced by stress recovered in the biting group but remained high in the non-biting group.", "output": {"entities": {}}, "schema": []}
{"input": "The only isolate of Aeromonas hydrophila produced cytotoxic enterotoxin and was invasive.", "output": {"entities": {}}, "schema": []}
{"input": "The incidence of early neonatal convulsions for inborn babies was 3. 0/1000 live births.", "output": {"entities": {}}, "schema": []}
{"input": "Of the 43 infants with a (probable) loss 18 were examined again at 3 months corrected age.", "output": {"entities": {}}, "schema": []}
{"input": "Variety of cows and sires according to types of dermatoglyphics (patterns) of the nose-labial mirror of cattle", "output": {"entities": {}}, "schema": []}
{"input": "Although not consistently identified in all samples, secondary Academic, Personal Responsibility, and Community/Vocational dimensions were also identified.", "output": {"entities": {}}, "schema": []}
{"input": "Recovery was characterized by rapid improvement such that all measured parameters normalized by 1 week, except for cross-sectional cardiac area which remained dilated up to 4 weeks (14 +/-3 cm2, p less than 0. 05 versus control). (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {}}, "schema": []}
{"input": "Not even extensive pancreatic resection could prevent pancreatic remnant infection.", "output": {"entities": {}}, "schema": []}
{"input": "It has been calculated that 600, 000 new cases of lung cancer occur worldwide every year, most of them due to smoking.", "output": {"entities": {}}, "schema": []}
{"input": "Incorporation of 0. 1 or 0. 2 M sodium dihydrogen phosphate in the sugar solutions resulted in a decrease in the shelf-life of diltiazem.", "output": {"entities": {}}, "schema": []}
{"input": "None had a past history of opportunistic infections; neither did any have lymphopenia.", "output": {"entities": {}}, "schema": []}
{"input": "Increasing the phosphorus content of the diet improved the reabsorption of calcium and magnesium.", "output": {"entities": {}}, "schema": []}
{"input": "Post-transcriptional regulation of ribosomal protein gene expression during development in Dictyostelium discoideum.", "output": {"entities": {"gene": [{"text": "ribosomal protein gene", "start": 35, "end": 57}]}}, "schema": []}
{"input": "The increase in amplitudes of the b-wave during the adaptation period was more prominent in lead-exposed subjects than in controls.", "output": {"entities": {}}, "schema": []}
{"input": "Possible factors for the development of psychotic symptomatology during group activities and the role of group dynamics acting as stress factors precipitating functional psychoses, especially bipolar manifestations, are discussed.", "output": {"entities": {}}, "schema": []}
{"input": "Baseline measurements of forced expiratory volume in 1 s (FEV1), specific airway conductance (SGaw) and the provocative dose of carbachol causing a 35% reduction in SGaw (PD35), and a 20% reduction in FEV1 (PD20) were established on entry while each subject was still smoking.", "output": {"entities": {}}, "schema": []}
{"input": "Many children with BGC are delayed in their development, but calcifications are not directly related to specific forms of neurologic dysfunction.", "output": {"entities": {}}, "schema": []}
{"input": "R-wave voltage in the right precordial leads in anthracycline cardiomyopathy: a clinical study.", "output": {"entities": {}}, "schema": []}
{"input": "The results indicate that the pooling requirements are task dependent.", "output": {"entities": {}}, "schema": []}
{"input": "These results indicate that CSFHU can increase neutrophil counts by increasing the number and maturity of the marrow neutrophil precursors in some types of childhood chronic neutropenia.", "output": {"entities": {"gene": [{"text": "CSFHU", "start": 28, "end": 33}]}}, "schema": []}
{"input": "The purposes of this study were 1) to examine the effect of high intensity, low frequency transcutaneous electrical nerve stimulation at auricular acupuncture points on experimental pain threshold measured at the wrist and 2) to determine the changes in effect over time.", "output": {"entities": {}}, "schema": []}
{"input": "In the infected neonates serum alpha-amylase value, as determined by the blue starch method, was only 40% that of healthy controls; the mean value of 175. 1 +/-64. 9 IU/l for healthy neonates was significantly higher (p less than 0. 0010) than the value of 82. 8 +/-44. 4 IU/l for the infected neonates.", "output": {"entities": {"gene": [{"text": "alpha-amylase", "start": 31, "end": 44}]}}, "schema": []}
{"input": "Records of 31 children with AIDS or AIDS-related complex admitted to the pediatric intensive care unit for acute respiratory failure throughout a 46-month period were reviewed.", "output": {"entities": {}}, "schema": []}
{"input": "SPECT is an important aid in the diagnosis of AIDS dementia complex and contributes to the understanding of the pathophysiological mechanisms of this disorder.", "output": {"entities": {}}, "schema": []}
{"input": "We were interested in studying the relationship between the circadian rhythm in body temperature and 24-h variations in plasma concentrations of iron, zinc, circulating leukocyte counts, and plasma interleukin 1 (IL-1) activity.", "output": {"entities": {"gene": [{"text": "interleukin 1", "start": 198, "end": 211}, {"text": "IL-1", "start": 213, "end": 217}]}}, "schema": []}
{"input": "The murine MHC class I genes, H-2Dq and H-2Lq, are strikingly homologous to each other, H-2Ld, and two genes reported to encode tumor-specific antigens.", "output": {"entities": {"gene": [{"text": "murine MHC class I genes", "start": 4, "end": 28}, {"text": "H-2Dq", "start": 30, "end": 35}, {"text": "H-2Lq", "start": 40, "end": 45}, {"text": "H-2Ld", "start": 88, "end": 93}]}}, "schema": []}
{"input": "The active derivatives of the present series were also tested for their analgesic activity against aconitine-induced writhing in albino mice and ulcerogenic activity in albino rats.", "output": {"entities": {}}, "schema": []}
{"input": "In untreated mice, bactericidal activity of peritoneal macrophages decreased from one day to 3 days after ip injection of killed L. monocytogenes.", "output": {"entities": {}}, "schema": []}
{"input": "Among a population of 18, 175 children below 7 years of age in medium sized towns and rural areas in south-western Germany 552 (3. 03%) cases of croup were registered during a 12 months period in 1984-85 by their physicians.", "output": {"entities": {}}, "schema": []}
{"input": "We concluded that Ga-fbg scintigraphy is a very simple method and sufficiently useful for detecting active left ventricular thrombi and for monitoring the effect of anticoagulant therapy.", "output": {"entities": {}}, "schema": []}
{"input": "In vitro assessment of the biocompatibility of dental materials--the millipore filter method.", "output": {"entities": {}}, "schema": []}
{"input": "Hypomagnesemia was due to magnesium wasting by the kidney.", "output": {"entities": {}}, "schema": []}
{"input": "Dentalplaque was controlled by the oral higienic index of the whole dentition daily, after staining with 1 per cent alkaline fuxin.", "output": {"entities": {}}, "schema": []}
{"input": "GRFI bound to sequences at the negative regulatory elements (silencers) of the silent mating type loci HML E and HMR E and to the upstream activating sequence (UAS) required for transcription of the MAT alpha genes.", "output": {"entities": {"gene": [{"text": "GRFI", "start": 0, "end": 4}, {"text": "silent mating type loci HML E", "start": 79, "end": 108}, {"text": "HMR E", "start": 113, "end": 118}, {"text": "MAT alpha genes", "start": 199, "end": 214}]}}, "schema": []}
{"input": "The effects of these mutations on RNA polymerase II activity were assayed by measuring the ability of mutant genes to confer alpha-amanitin resistance after transfection of susceptible rodent cells.", "output": {"entities": {"gene": [{"text": "RNA polymerase II", "start": 34, "end": 51}, {"text": "alpha-amanitin", "start": 125, "end": 139}]}}, "schema": []}
{"input": "We report the use of a new technetium-99m-albumin colloid white blood cell (TAC-WBC) scan in the evaluation of appendicitis.", "output": {"entities": {"gene": [{"text": "albumin", "start": 42, "end": 49}]}}, "schema": []}
{"input": "In one of these tumors the observed rearrangement was not due to the insertion of an intact MoMuLV provirus.", "output": {"entities": {}}, "schema": []}
{"input": "The indications for its use include every primary and secondary rhinoplasty candidate unless tip grafts are going to be under tension or if the deformity is minor.", "output": {"entities": {}}, "schema": []}
{"input": "Mutations at the suf12 locus were isolated in Saccharomyces cerevisiae as extragenic suppressors of + 1 frameshift mutations in glycine (GGX) and proline (CCX) codons, as well as UGA and UAG nonsense mutations.", "output": {"entities": {"gene": [{"text": "suf12 locus", "start": 17, "end": 28}]}}, "schema": []}
{"input": "The behavior of suf12-null/SUF12 + heterozygotes indicates that suf12 is co-dominantly expressed and suggests that suf12 allele-specific suppression may result from functionally distinct mutant proteins rather than variation in residual wild-type SUF12 + activity.", "output": {"entities": {"gene": [{"text": "suf12-null/SUF12 + heterozygotes", "start": 16, "end": 48}, {"text": "suf12", "start": 64, "end": 69}, {"text": "suf12", "start": 115, "end": 120}, {"text": "wild-type SUF12 +", "start": 237, "end": 254}]}}, "schema": []}
{"input": "Antituberculosis agents.", "output": {"entities": {}}, "schema": []}
{"input": "The putative immunity protein was detected among the [35S] methionine-labelled proteins produced by minicells carrying cni cloned under lac promoter control, and when the gene was subcloned into expression vectors under the control of a bacteriophage T7 promoter.", "output": {"entities": {"gene": [{"text": "cni", "start": 119, "end": 122}, {"text": "lac promoter", "start": 136, "end": 148}]}}, "schema": []}
{"input": "Antibodies made against fusion protein produced by the DP1A clone reacted specifically with DP-I and-II on immunoblots.", "output": {"entities": {"gene": [{"text": "DP1A", "start": 55, "end": 59}, {"text": "DP-I and-II", "start": 92, "end": 103}]}}, "schema": []}
{"input": "Finally, over a similar range of QO2, oxygen extraction was greater in patients with ARDS compared to patients with non-ARDS respiratory failure (r =-0. 67 and slope =-0. 62 vs r =-0. 45 and slope =-0. 35; p less than 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "Stable patients have mucous hypersecretion and little evidence of acute inflammation.", "output": {"entities": {}}, "schema": []}
{"input": "Hyperprolactinaemia, moderate hypogonadism, infraclinical neuropathies, arterial stenoses and moderate venous leakages seem to play a partial role of organic starter or cofactor, the sexual consequences of which are amplified by psychological factors, partly secondary to the initial sexual failures.", "output": {"entities": {}}, "schema": []}
{"input": "Yang and H.", "output": {"entities": {}}, "schema": []}
{"input": "Secretory function of the prostate gland.", "output": {"entities": {}}, "schema": []}
{"input": "Chronic endotoxemia appears to be associated with an elevated pulmonary microvascular permeability and a tendency toward a hyperdynamic circulation but with an appreciable degree of refractoriness associated with regional hemodynamics and eicosanoid biosynthesis.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast, we observed high concentrations in 29 of 75 patients with tumors of the central nervous system, especially in meningioma (6/9), glioblastoma (9/23), and neurinoma (5/5).", "output": {"entities": {}}, "schema": []}
{"input": "Diet and atopic eczema.", "output": {"entities": {}}, "schema": []}
{"input": "Time delay effects on the tensile bond strength developed by the Silicoater.", "output": {"entities": {}}, "schema": []}
{"input": "The future of research with interferon may be divided into three areas: Efforts must be made to determine how best to translate the in vitro synergy into clinically meaningful terms; in order to exploit the fullest potential of IFN, research is moving toward using this agent earlier in disease either as an adjuvant after tumor debulking or after initial diagnosis; the medical community must rethink the natural history of some diseases, because the fullest potential of the biologic agents will most likely manifest itself when these agents are used together.", "output": {"entities": {"gene": [{"text": "interferon", "start": 28, "end": 38}, {"text": "IFN", "start": 228, "end": 231}]}}, "schema": []}
{"input": "Six healthy male subjects received single oral doses of regular release (RR) quinidine sulfate, sustained release (SR) quinidine bisulfate and the same dose of the SR product with food (SR-F).", "output": {"entities": {}}, "schema": []}
{"input": "This report expands on previous work with interferon alfa-2b (Intron A; Schering-Plough) in the treatment of hairy cell leukemia (HCL).", "output": {"entities": {"gene": [{"text": "interferon alfa-2b (Intron A; Schering-Plough)", "start": 42, "end": 88}]}}, "schema": []}
{"input": "Oxygen delivery and base excess decreased significantly and four pigs died.", "output": {"entities": {}}, "schema": []}
{"input": "Clinical chemistry.", "output": {"entities": {}}, "schema": []}
{"input": "Revascularization after anterior maxillary and mandibular osteotomy", "output": {"entities": {}}, "schema": []}
{"input": "Static orthoses for the management of microstomia.", "output": {"entities": {}}, "schema": []}
{"input": "The intrapancreatic spread of the carcinoma correlated with portal invasion of carcinoma, hardness of the body and tail, obstruction of main pancreatic duct and irregular pancreaticogram.", "output": {"entities": {}}, "schema": []}
{"input": "Lysosomal enzymes that degrade cartilage are released.", "output": {"entities": {}}, "schema": []}
{"input": "Contrary to the observation made with other S. pombe genes transcribed in the budding yeast, the heterologous actin gene transcript is initiated 39 nucleotides upstream of the initiation start site used in the homologous yeast.", "output": {"entities": {"gene": [{"text": "actin gene transcript", "start": 110, "end": 131}]}}, "schema": []}
{"input": "A multicentre study involving 9 Italian institutions was carried out to compare the efficacy and safety of ranitidine 150 mg b. i. d. and ranitidine 300 mg nocte in the treatment of reflux oesophagitis.", "output": {"entities": {}}, "schema": []}
{"input": "Monotherapy with ceftazidime was clinically and bacteriologically as effective as a combination therapy with cefazolin and tobramycin.", "output": {"entities": {}}, "schema": []}
{"input": "The N3 wave of the SSEP' s, which has been found to correlate best with neurological recovery, returned to 65% +/-48% of the preischemia amplitude in the insulin-treated animals, compared to 40% +/-34% in the fasted group and 26% +/-24% in the control animals.", "output": {"entities": {"gene": [{"text": "insulin", "start": 154, "end": 161}]}}, "schema": []}
{"input": "Proctoscopy and roentgenographic studies may be an important part of evaluation, especially in patients who present with perianal suppuration, masses, or anal fissures.", "output": {"entities": {}}, "schema": []}
{"input": "In the control group the histological picture resembled osteoarthritis.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast to this mRNA, 90% of alpha and beta actin mRNAs were translated in both myoblasts and myotubes.", "output": {"entities": {"gene": [{"text": "alpha and beta actin mRNAs", "start": 33, "end": 59}]}}, "schema": []}
{"input": "If this is unavailable, then Supramid has a proven record for good tissue compatibility and resistance to infection.", "output": {"entities": {}}, "schema": []}
{"input": "The size of the group allocated to the good compliance category by the use of the digoxin marker was equivalent in size to a group of patients who had returned less than 15% of their prescribed dose or reported a deviation of less than 6% from their prescription.", "output": {"entities": {}}, "schema": []}
{"input": "Bullous keratopathy was usually aphakic in origin in 1982, but after 1983 pseudophakic bullous keratopathy (PBK) was the most common cause of bullous keratopathy.", "output": {"entities": {}}, "schema": []}
{"input": "The ultrastructural findings, as well as the urinary C-peptide excretion, confirmed that the glycemic effects should not be thought to be due to a direct action of the drugs used on the endocrine pancreas.", "output": {"entities": {"gene": [{"text": "C-peptide", "start": 53, "end": 62}]}}, "schema": []}
{"input": "In vitro antimalarial activity of neem (Azadirachta indica A.", "output": {"entities": {}}, "schema": []}
{"input": "\" In vitro \" study of dentin adhesion to adhesives made from urethane molecules with free groups of isocyanate", "output": {"entities": {}}, "schema": []}
{"input": "There is a cysteine clustering region in an N-terminal region of the c-raf (-1) product deduced from the nucleotide sequence, and this cysteine clustering region was found to be highly homologous to that present in an N-terminal region of protein kinase C, although, in the latter cysteine clusters are present in duplicate.", "output": {"entities": {"gene": [{"text": "c-raf (-1) product", "start": 69, "end": 87}, {"text": "protein kinase C", "start": 239, "end": 255}]}}, "schema": []}
{"input": "Hand-held, continuous-wave Doppler probes, coupled with sound spectral analysis, can successfully predict carotid artery stenosis.", "output": {"entities": {}}, "schema": []}
{"input": "The German Society of Pediatric Oncology in 1981 initiated the Cooperative Ewing' s Sarcoma Study (CESS 81) using a four-drug combination of chemotherapy prior to definitive local control with surgery and/or radiation.", "output": {"entities": {}}, "schema": []}
{"input": "The program has been written in a generic BASIC in order to make the procedure user-friendly.", "output": {"entities": {}}, "schema": []}
{"input": "Since high levels of immunoglobulin G were demonstrated against the surface of the NVS after immunization, passive transfer experiments were initiated.", "output": {"entities": {"gene": [{"text": "immunoglobulin G", "start": 21, "end": 37}]}}, "schema": []}
{"input": "A study was conducted of a human male who had inhaled a mixture of 241Am and Pu.", "output": {"entities": {}}, "schema": []}
{"input": "An analytic method for comparative parameter weighting in magnetic resonance (MR) imaging has been developed using the concept of \" fractional sensitivity. \" This new approach results in easily calculated indexes for T1, T2, and hydrogen weighting.", "output": {"entities": {}}, "schema": []}
{"input": "Fifty-four patients were divided into groups according to their clinical presentation; seven asymptomatic volunteers, 20 patients with duodenal-gastric reflux gastropathy (DRG), 16 patients with recurrent ulcers of the duodenal bulb (RUD), and 11 patients with Moynihan' s disease.", "output": {"entities": {}}, "schema": []}
{"input": "No previous studies have determined the pharmaco-dynamics of intravenous procainamide when administered in a dose of 15 mg/kg and at a rate of 50 mg/min, as is common practice during electropharmacologic testing.", "output": {"entities": {}}, "schema": []}
{"input": "High concentrations of tumor-associated trypsin inhibitor in hemodialyzed patients.", "output": {"entities": {"gene": [{"text": "trypsin", "start": 40, "end": 47}]}}, "schema": []}
{"input": "In the chicken liver, levels of chicken MT mRNA were rapidly induced by metals (Cd2 +, Zn2 +, Cu2 +), glucocorticoids and lipopolysaccharide.", "output": {"entities": {"gene": [{"text": "chicken MT mRNA", "start": 32, "end": 47}]}}, "schema": []}
{"input": "With histology and Evans blue injections, blood-brain barrier alterations were seen as early as 4 days after a dose of 50 Gy.", "output": {"entities": {}}, "schema": []}
{"input": "Dosimetric estimates for these organs were 2. 3 +/-1. 1 and 2. 3 +/-1. 4 rad (. 02 +/-. 01 Gy), respectively, with a whole-body estimate of 0. 28 rad (. 003 Gy).", "output": {"entities": {}}, "schema": []}
{"input": "A significant association between a family history and a higher urinary pH was observed among the female calcium stone patients.", "output": {"entities": {}}, "schema": []}
{"input": "New technologies in diagnosis and classification of malignancy.", "output": {"entities": {}}, "schema": []}
{"input": "Thus the present data also suggest that BP and HR measurements are influenced not only by state-dependent factors but also by at least three different factors that are each independent of the state: one leads to BP and HR values that are influenced by the cycle the animal is in and the other two influence, respectively, the ranking of the individual' s BP and HR levels within the population.", "output": {"entities": {}}, "schema": []}
{"input": "The correlation between PaCO2 and PtcO2 in RDS was insufficient to make clinical judgement.", "output": {"entities": {}}, "schema": []}
{"input": "Since 1967 at the times of their biennial ABCC/RERF radiological examinations, all Adult Health Study (AHS) subjects have been interviewed to determine the exposures to medical x-rays they experienced in institutions other than RERF in order to estimate the numbers of examinations and corresponding doses which they received.", "output": {"entities": {}}, "schema": []}
{"input": "One millimolar ouabain completely inhibited net HCO3-secretion.", "output": {"entities": {}}, "schema": []}
{"input": "There are regions with long runs of up to 45% C or 35% G residues.", "output": {"entities": {}}, "schema": []}
{"input": "The same rhythmic structure enables a prediction to be made concerning when vowels of stressed syllables will be auditorily perceived.", "output": {"entities": {}}, "schema": []}
{"input": "Vocal cord abduction rehabilitation by nervous selective anastomosis.", "output": {"entities": {}}, "schema": []}
{"input": "UK' s biotechnology lacking specialists.", "output": {"entities": {}}, "schema": []}
{"input": "Distant spread was found in 46 patients (34%), 42 of whom had serum Tg greater than 10 micrograms/l.", "output": {"entities": {"gene": [{"text": "Tg", "start": 68, "end": 70}]}}, "schema": []}
{"input": "The glomerular filtration rate and effective renal plasma flow were determined by a standard clearance method, employing continuous infusion of inulin and para-aminohippuric acid.", "output": {"entities": {}}, "schema": []}
{"input": "After the meal containing potato, plasma glucose levels rose sharply, peaked at 30-45 min and fell below initial levels 2 to 3 h later.", "output": {"entities": {}}, "schema": []}
{"input": "The relations among various negative emotional and behavioral characteristics (e. g., aggression, anxiety, undercompliance, depressive mood) and adjustment were examined through use of data from the 31-year-old New York Longitudinal Study.", "output": {"entities": {}}, "schema": []}
{"input": "To evaluate the effect of altitude on adolescent growth and development, three groups of healthy, well-nourished youth of similar socioeconomic status and ethnic grouping who resided at sea level (n = 1262 subjects), mid-altitude (n = 1743 subjects), and high altitude (n = 1137 subjects) were studied.", "output": {"entities": {}}, "schema": []}
{"input": "Because the CAP measures variables predictive of abusive behavior, a substantial relationship was expected between the CAP and the MHI Loss of Behavioral/Emotional Control scale.", "output": {"entities": {}}, "schema": []}
{"input": "We have improved our system for nuclear contour digitization and determined its theoretical limitations by digitizing standardized objects.", "output": {"entities": {}}, "schema": []}
{"input": "Such a change may involve increased mammary utilization of pre-formed long-chain fatty acid and increased metabolism of glucose via glycolysis.", "output": {"entities": {}}, "schema": []}
{"input": "The skin site, 6-cm-distal and-proximal subcutaneous segments of the catheter, exudates, and blood were cultured.", "output": {"entities": {}}, "schema": []}
{"input": "Because of its great reliability, conventional arteriography occupies a place of choice among the medical imaging techniques.", "output": {"entities": {}}, "schema": []}
{"input": "Rapid detection of radioisotopically contaminated test serum before radioassay of vitamin B12.", "output": {"entities": {}}, "schema": []}
{"input": "The former group did excrete less dry fecal material compared to both other groups.", "output": {"entities": {}}, "schema": []}
{"input": "Electronic data processing (EDP) latex immunoassay using anti-human seminal acid phosphatase (anti-HSAP) immune serum was applied for the species and organ identification of human seminal stains.", "output": {"entities": {"gene": [{"text": "anti-human seminal acid phosphatase", "start": 57, "end": 92}, {"text": "anti-HSAP", "start": 94, "end": 103}]}}, "schema": []}
{"input": "The maximum deflections of phase IV for Ar and N2 from extrapolated phase III slopes were smaller in the prone position, suggesting more uniform tracer gas concentrations across the lungs.", "output": {"entities": {}}, "schema": []}
{"input": "Recent developments in drugs antagonistic to factors causing peptic ulcer--clinical efficacy and problems; gastrin receptor blockaders", "output": {"entities": {"gene": [{"text": "gastrin receptor", "start": 107, "end": 123}]}}, "schema": []}
{"input": "Static magnetic fields affect the diffusion of biological particles in solutions through the Lorentz force and Maxwell stress.", "output": {"entities": {}}, "schema": []}
{"input": "Psychological disturbance was greater in the high life stress group as indicated by significant elevations on the global severity index of the Symptom Checklist-90 and elevations on somatization, obsessive compulsive, interpersonal sensitivity, depression, anxiety and psychoticism subscales.", "output": {"entities": {}}, "schema": []}
{"input": "Chronic administration of sodium cyanate decreases O2 extraction ratio in dogs.", "output": {"entities": {}}, "schema": []}
{"input": "Nucleotide sequencing indicates that this E1 alpha cDNA clone is 1821 base pairs (bp) in length with an open reading frame of 1365 bp and a 3'-untranslated region of 356 bp.", "output": {"entities": {"gene": [{"text": "E1 alpha cDNA", "start": 42, "end": 55}]}}, "schema": []}
{"input": "SPA from PAG sites was associated with aversion.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast, the MAN showed a unimodal, skewed distribution, with a range from approximately 1 to 14 micron and a maximum at 3-4 micron.", "output": {"entities": {}}, "schema": []}
{"input": "Abnormal technetium Tc 99m medronate scans in patients with previously undiagnosed polyarthralgias suggested inflammatory arthropathy and influenced management decisions with favorable therapeutic outcomes.", "output": {"entities": {}}, "schema": []}
{"input": "Practical interest of such studies is limited since the pharmacokinetic parameters are systematically evaluated in man during phase I trials.", "output": {"entities": {}}, "schema": []}
{"input": "The artery cuff was slightly superior to the fat wrap, particularly in having fewer adhesions and a better histological picture.", "output": {"entities": {}}, "schema": []}
{"input": "Lithium-carbonate action during radiation therapy has been studied, valuing the positive effect on leukopoiesis and the consequent better clinical conditions of the patients in course of treatment.", "output": {"entities": {}}, "schema": []}
{"input": "Of the 53 units tested during sinusoidal motion at 0. 05 Hz (9. 1 cm/s), 1 (1. 9%) was responsive to the otolith input only, 13 (24. 5%) were influenced by the visual input only and 23 (43. 4%) responded to both modalities.", "output": {"entities": {}}, "schema": []}
{"input": "Electroglottography is a useful, non-invasive technique that can assist in the assessment of vocal fold dysfunction.", "output": {"entities": {}}, "schema": []}
{"input": "Statistical analysis of the degrees of secondary spinal cord compression was performed in group-1 dogs by measuring and comparing ratios of the vertical to the horizontal diameters of the transverse spinal cord sections from locations within (T12 to L1) and out of (T11, T11-12, L1-2, and L2) the region of surgical intervention.", "output": {"entities": {}}, "schema": []}
{"input": "The pharmacological effects of the novel compound WEB 1881 FU (4-amino-methyl-1-benzyl-pyrrolidine-2-one-fumarate) were investigated.", "output": {"entities": {}}, "schema": []}
{"input": "Histopathological examination revealed dose-related proliferation of type II pneumocytes in dams and proliferation of interstitial cells and delayed septal/capillary development in neonates. (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {}}, "schema": []}
{"input": "So far no problems with multiply resistant strains have developed.", "output": {"entities": {}}, "schema": []}
{"input": "The state of the liver in generalized forms of meningococcal infection", "output": {"entities": {}}, "schema": []}
{"input": "The effects produced by oral administration of 500 mg/kg p-xylene or toluene lasted at least 8 hr, while the effect of inhaled p-xylene dissipated within 75 min of removal from the exposure.", "output": {"entities": {}}, "schema": []}
{"input": "Thin melanomas can metastasize and be lethal.", "output": {"entities": {}}, "schema": []}
{"input": "The TA muscle was fatigued by four forms of repeated isometric contractions: (1) maximal voluntary contractions (MVC), (2) MVC with circulation occluded, (3) electrically evoked contractions with 20 Hz supramaximal voltage stimulation and (4) electrically evoked contractions with circulation occluded.", "output": {"entities": {}}, "schema": []}
{"input": "The actuarial local control rates at 10 years for the three treatment groups were as follows: subtotal excision alone, 18%; subtotal excision plus postoperative radiation therapy, 82%; and total excision alone, 77%.", "output": {"entities": {}}, "schema": []}
{"input": "The effects of anabolic implants on rate, composition and energetic efficiency of growth were determined in steers fed diets varying in forage and grain content.", "output": {"entities": {}}, "schema": []}
{"input": "Prolonged suspension induced a significant change in the geometric configuration of the femur middiaphysis by increasing the minimum diameter (12%) without any significant alterations in cortical area, density, mineral, and collagen concentrations.", "output": {"entities": {"gene": [{"text": "collagen", "start": 224, "end": 232}]}}, "schema": []}
{"input": "Thyroid function tests were performed on 300 admissions, leaving 707 untested.", "output": {"entities": {}}, "schema": []}
{"input": "Data on the line spread function (LSF) were obtained from the image of a 0. 2 mm wide slit between tungsten blocks that were positioned at the isocentre in front of a polystyrene phantom.", "output": {"entities": {}}, "schema": []}
{"input": "Primary infection is usually managed conservatively.", "output": {"entities": {}}, "schema": []}
{"input": "Papers of the Society for Clinical Vascular Surgery.", "output": {"entities": {}}, "schema": []}
{"input": "Prognosis in Bowen' s disease localized to the ano-genital region.", "output": {"entities": {}}, "schema": []}
{"input": "Taken together, the results suggest that chlorphentermine may be capable of producing dual stimulus effects in animals.", "output": {"entities": {}}, "schema": []}
{"input": "These findings indicate that autophosphorylation of Thr286 (alpha subunit) and Thr287 (beta subunit) is responsible for transition of CaM-kinase II to the Ca2 +-independent form.", "output": {"entities": {"gene": [{"text": "CaM-kinase II", "start": 134, "end": 147}]}}, "schema": []}
{"input": "This rapid and extensive penetration of intrathecally administered chemotherapy may offer insight into the myelopathy observed with these treatments.", "output": {"entities": {}}, "schema": []}
{"input": "The interaction of radiation and hyperthermia was systematically studied in the Dunning R3327G prostatic adenocarcinoma, the preeminent animal model for human prostatic cancer.", "output": {"entities": {}}, "schema": []}
{"input": "Pregnant rats were exposed to one of the following: (1) 10% O2 in N2 or 100% O2 for 2 days beginning at day 7, 11, 14, or 18 of pregnancy; (2) 10% O2 in N2 or 100% O2 for 10 h/day beginning at day 7; or (3) 14-11% O2 in N2 continuously beginning at day 14 till day 21 when they were sacrificed.", "output": {"entities": {}}, "schema": []}
{"input": "Seven patients (8. 3 percent) had latent hypothyroidism only discovered by hormonal determinations.", "output": {"entities": {}}, "schema": []}
{"input": "Addition of sucralfate or De-Nol resulted in increments of gastric HCO3 secretion, reaching about 45% and 59%, respectively, of the maximal HCO3 response to 16, 16-dimethyl PGE2 (dmPGE2).", "output": {"entities": {}}, "schema": []}
{"input": "Moreover, unlike control rats operated animals did not show aversion to the highest concentrations of saccharin solutions.", "output": {"entities": {}}, "schema": []}
{"input": "In Salmo gairdneri, no specialized system of portal vessels appears to exist between the pineal organ and other portions of the brain.", "output": {"entities": {}}, "schema": []}
{"input": "Nuclear factor III (NFIII) is a protein from HeLa cells that stimulates the initiation of adenovirus type 2 (Ad2) DNA replication by binding to a specific nucleotide sequence in the origin, adjacent to the nuclear factor I recognition site.", "output": {"entities": {"gene": [{"text": "Nuclear factor III", "start": 0, "end": 18}, {"text": "NFIII", "start": 20, "end": 25}, {"text": "nuclear factor I recognition site", "start": 206, "end": 239}]}}, "schema": []}
{"input": "We conclude that cephalothin clearance of S. aureus from a site accessible to phagocytes was delayed when compared to a phagocyte-inaccessible site.", "output": {"entities": {}}, "schema": []}
{"input": "The findings are discussed in the context of known properties of cortical-bar detectors.", "output": {"entities": {}}, "schema": []}
{"input": "Mean rCBF increased in some patients 4-8 weeks after surgery on the ipsilateral side.", "output": {"entities": {}}, "schema": []}
{"input": "Quantitative computed tomography for measuring vertebral bone mineral content offers high sensitivity and reproducibility.", "output": {"entities": {}}, "schema": []}
{"input": "The structure of the enhancer was also probed by inserting a pair of complementary synthetic oligodeoxynucleotides which represented the region between nt positions-235 and-215 into a truncated template which lacked the enhancer.", "output": {"entities": {}}, "schema": []}
{"input": "Kf, c and CT (referenced to the initial lung mass) decreased linearly with reductions in lung mass% delta Kf, c = 1. 26-0. 98% mass removed (r = 0. 90, P less than 0. 01) and% delta CT =-3. 99-0. 98% mass removed (r = 0. 82, P less than 0. 01) relationships that were not altered by blocker pretreatment. (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {}}, "schema": []}
{"input": "Two scintigraphic methods, resting dipyridamole and exercise thallium-201 myocardial perfusion imaging, to detect and localize coronary artery stenosis were compared in 32 patients suffering from coronary artery disease.", "output": {"entities": {}}, "schema": []}
{"input": "From these results, it is concluded that EDLF has clear vasoconstrictor properties which are not due to adrenergic or calcium entry mechanisms and that there are differences in the vasoconstrictor effects of EDLFs with respect to different vascular beds.", "output": {"entities": {}}, "schema": []}
{"input": "Research was carried out on the rheumatoid factors in the serum of 917 patients by means of two tests (one using polystyrene and one with erythrocytes) and the results obtained were compared using a method of reference.", "output": {"entities": {"gene": [{"text": "rheumatoid factors", "start": 32, "end": 50}]}}, "schema": []}
{"input": "A low aspirin esterase activity may be a contributory factor in precipitating these aspirin sensitive reactions.", "output": {"entities": {"gene": [{"text": "aspirin esterase", "start": 6, "end": 22}]}}, "schema": []}
{"input": "In both experiments, average daily gain and gain-to-feed ratio were similar for TR and CR.", "output": {"entities": {}}, "schema": []}
{"input": "Overall least-squares means for uncooked and cooked longissimus muscle and subcutaneous fat were 63. 32, 80. 27 and 98. 90 mg of cholesterol/100 g of tissue, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "The role of supercritical fluid chromatography (SFC) as a viable technique for analyzing agricultural products has been investigated using packed and capillary column methodology.", "output": {"entities": {}}, "schema": []}
{"input": "Nitrofurazone significantly reduced the rise in LH induced by LHRH.", "output": {"entities": {"gene": [{"text": "LH", "start": 48, "end": 50}, {"text": "LHRH", "start": 62, "end": 66}]}}, "schema": []}
{"input": "Ovarian tumors in pregnancy.", "output": {"entities": {}}, "schema": []}
{"input": "Ultrastructural study of polyarteritis", "output": {"entities": {}}, "schema": []}
{"input": "X2 test, with Yates correction if need, was used as statistical. method.", "output": {"entities": {}}, "schema": []}
{"input": "After a baseline study, WPW syndrome was simulated by stimulation at seven different sites around the base of the ventricles, and RNV' s were obtained.", "output": {"entities": {}}, "schema": []}
{"input": "All patients had the CA 125 assay performed within one week before their second-look operation.", "output": {"entities": {"gene": [{"text": "CA 125", "start": 21, "end": 27}]}}, "schema": []}
{"input": "Allergy and Tourette' s syndrome.", "output": {"entities": {}}, "schema": []}
{"input": "The criterion was reached after two sessions and generalization to a variety of pills and capsules occurred.", "output": {"entities": {}}, "schema": []}
{"input": "Clinical method for the treatment of Class II occlusal anomalies with open bite", "output": {"entities": {}}, "schema": []}
{"input": "Enoxacin appears to be well suited for the treatment of complicated UTI.", "output": {"entities": {}}, "schema": []}
{"input": "An industry-wide retrospective cohort mortality study was conducted on 6, 152 chemical workers (2, 460 exposed and 3, 692 nonexposed) engaged in chloromethyl ether manufacture at 7 major U. S. companies between 1948 and 1980.", "output": {"entities": {}}, "schema": []}
{"input": "The diagnosis of amyloidosis was determined from a labial salivary gland biopsy.", "output": {"entities": {}}, "schema": []}
{"input": "Hair and blood samples were taken before vitamin C or placebo supplementation was started and at monthly intervals thereafter for three months.", "output": {"entities": {}}, "schema": []}
{"input": "In treated herds, cows more than 40 d postpartum with a corpus luteum received prostaglandin F2 alpha.", "output": {"entities": {}}, "schema": []}
{"input": "Emergency treatment of facial and maxillary/mandibular injuries", "output": {"entities": {}}, "schema": []}
{"input": "In 14 cases, isolates were biotyped yielding eight with biotype II, four with biotype III, and one each with biotypes IV and V.", "output": {"entities": {}}, "schema": []}
{"input": "A total of 117 EVS treatments were performed on 34 patients.", "output": {"entities": {}}, "schema": []}
{"input": "Most of the prepeptide portion of the precursor polypeptide is encoded by the next three exons, and the mature form of IL-1 alpha is encoded by the remaining three exons.", "output": {"entities": {"gene": [{"text": "IL-1 alpha", "start": 119, "end": 129}]}}, "schema": []}
{"input": "A stochastic version of Kernell' s (1968, 1972) model with cumulative afterhyperpolarization (AHP) was simulated.", "output": {"entities": {}}, "schema": []}
{"input": "In a previous interim report we noted more prompt resolution of dermatomal signs and symptoms with acyclovir treatment.", "output": {"entities": {}}, "schema": []}
{"input": "The detectability of the defects in RCA or LAD region was 80% in single-position scans in stress studies.", "output": {"entities": {}}, "schema": []}
{"input": "Pharmacologic properties of serotonergic agents and antidepressant drugs.", "output": {"entities": {}}, "schema": []}
{"input": "This brief hypercapnic challenge induced a rapid increase in CBF in the absence of any change in MABP.", "output": {"entities": {}}, "schema": []}
{"input": "Osteocalcin (serum bone-Gla protein, sBGP), serum alkaline phosphatase (sAP) and urinary hydroxyproline/creatinine ratio (uOH-Prol/creatinine) have been measured in 21 patients with primary hyperparathyroidism (PHPT) and in nine patients with hypercalcaemia of malignancy (HM).", "output": {"entities": {"gene": [{"text": "Osteocalcin", "start": 0, "end": 11}, {"text": "serum bone-Gla protein", "start": 13, "end": 35}, {"text": "sBGP", "start": 37, "end": 41}, {"text": "serum alkaline phosphatase", "start": 44, "end": 70}, {"text": "sAP", "start": 72, "end": 75}]}}, "schema": []}
{"input": "Multivariate logistic regression analysis indicated that seropositivity was strongly associated with the prevalence of hepatitis B in an employee' s country of birth and with age.", "output": {"entities": {}}, "schema": []}
{"input": "Hexsyn is the Goodyear Tire and Rubber Company tradename for a polyolefin rubber synthesized from 1-hexene with 3-5% methylhexadiene as the source of residual double bonds for vulcanization.", "output": {"entities": {}}, "schema": []}
{"input": "Chimeric phage-plasmid expression vectors were constructed from pUC18/19 plasmids by cloning a single-stranded DNA (ssDNA) origin of replication from bacteriophage f1 and inserting a bacteriophage T7 promoter within the beta-galactosidase gene.", "output": {"entities": {"gene": [{"text": "beta-galactosidase gene", "start": 220, "end": 243}]}}, "schema": []}
{"input": "By order of decreasing rate, finger flexors, jaw, crossed adductors, and triceps reflexes were less frequently elicited in both groups.", "output": {"entities": {}}, "schema": []}
{"input": "Natl.", "output": {"entities": {}}, "schema": []}
{"input": "Five out of eight consecutive cases with initial symptoms of a' midline granuloma' were identified as malignant histiocytosis (histiocytic sarcoma) which within 5 months to 4 years led to generalization and death.", "output": {"entities": {}}, "schema": []}
{"input": "All patients then received suxamethonium 1. 5 mg kg-1 i. v.", "output": {"entities": {}}, "schema": []}
{"input": "The highest postoperative CK-MB level was less after BC (BC, 31 +/-17 U/L; CC, 56 +/-13 U/L; p less than 0. 05).", "output": {"entities": {"gene": [{"text": "CK-MB", "start": 26, "end": 31}]}}, "schema": []}
{"input": "No relevant changes in heart rate, body weight, and plasma levels of renin activity and aldosterone concentration were observed.", "output": {"entities": {"gene": [{"text": "renin", "start": 69, "end": 74}]}}, "schema": []}
{"input": "High trough serum TOB concentrations were associated with death and very low levels with recovery.", "output": {"entities": {}}, "schema": []}
{"input": "State-approved schools of nursing R. N.", "output": {"entities": {}}, "schema": []}
{"input": "In a maxicell system a protein with an approximate molecular weight of 36, 000 was synthesized.", "output": {"entities": {}}, "schema": []}
{"input": "The incidence of second malignant neoplasms was lower (1. 3%) in the group treated with 5-fluorouracil, doxorubicin, and cyclophosphamide than in the historical control group (4. 8%).", "output": {"entities": {}}, "schema": []}
{"input": "Ovulation was induced in 8 (56. 7%) patients who conceived.", "output": {"entities": {}}, "schema": []}
{"input": "In previous work (E.", "output": {"entities": {}}, "schema": []}
{"input": "The small size and placement of the mutagenesis marker (the supF suppressor tRNA gene from Escherichia coli) within the vector substantially reduced the frequency of spontaneous mutations normally observed after transfection of mammalian cells with plasmid DNA; hence, UV-induced mutations were easily identified above the spontaneous background.", "output": {"entities": {"gene": [{"text": "supF suppressor tRNA gene from Escherichia coli", "start": 60, "end": 107}]}}, "schema": []}
{"input": "W.", "output": {"entities": {}}, "schema": []}
{"input": "Tetrad analysis and mitotic recombination experiments localized the PEP4 gene proximal to GAL4 on chromosome XVI.", "output": {"entities": {"gene": [{"text": "PEP4 gene", "start": 68, "end": 77}, {"text": "GAL4", "start": 90, "end": 94}]}}, "schema": []}
{"input": "Based on our observations, we propose a model whereby inactive precursor molecules produced from the PEP4 gene self-activate within the yeast vacuole and subsequently activate other vacuolar hydrolases.", "output": {"entities": {"gene": [{"text": "PEP4 gene", "start": 101, "end": 110}, {"text": "vacuolar hydrolases", "start": 182, "end": 201}]}}, "schema": []}
{"input": "In vitro translation of RNA synthesized from the cloned cDNAs predicts that P0 transcripts are translated into a novel 12. 5-kilodalton protein corresponding to the first open reading frame.", "output": {"entities": {"gene": [{"text": "P0 transcripts", "start": 76, "end": 90}]}}, "schema": []}
{"input": "The N-terminal amino acid sequence of Mop has sequence homology with DNA binding proteins.", "output": {"entities": {"gene": [{"text": "Mop", "start": 38, "end": 41}]}}, "schema": []}
{"input": "Several new techniques are available for monitoring control of diabetes.", "output": {"entities": {}}, "schema": []}
{"input": "Ciprofloxacin: an overview of adverse experiences.", "output": {"entities": {}}, "schema": []}
{"input": "The rho genes comprise an evolutionarily conserved family with significant homology to the ras oncogene family.", "output": {"entities": {"gene": [{"text": "rho genes", "start": 4, "end": 13}, {"text": "ras oncogene family", "start": 91, "end": 110}]}}, "schema": []}
{"input": "Also, component I significantly correlated with fasting insulin and VO2 max for both sexes and with basal metabolism and HDL-cholesterol for females and males, respectively.", "output": {"entities": {"gene": [{"text": "insulin", "start": 56, "end": 63}, {"text": "HDL-cholesterol", "start": 121, "end": 136}]}}, "schema": []}
{"input": "The glucose areas following the ingestion of the foods were: Study 1: glucose 11. 7, orange juice 7. 3, sucrose 5. 2, glucose + fructose 6. 3, and fructose 0. 7 mmol X h/l; Study 2: glucose 14. 6, orange juice 7. 3, apples 5. 5, and apple juice 4. 7 mmol X h/l; Study 3: glucose 12. 6, ice cream 8. 1, milk 3. 7, and lactose 4. 1 mmol X h/l.", "output": {"entities": {}}, "schema": []}
{"input": "The serum insulin response cannot.", "output": {"entities": {"gene": [{"text": "serum insulin", "start": 4, "end": 17}]}}, "schema": []}
{"input": "SCL prolonged promptly after verapamil, and sinus arrest developed in two of 10 group 2 and two of five group 3 animals.", "output": {"entities": {}}, "schema": []}
{"input": "Postglucose serum insulin levels showed no significant correlations with systolic or diastolic blood pressure levels in men, but in female diabetic and non-diabetic subjects significant correlations were found in particular with systolic blood pressure level.", "output": {"entities": {"gene": [{"text": "serum insulin", "start": 12, "end": 25}]}}, "schema": []}
{"input": "We used oligonucleotide-directed mutagenesis to alter a site in MucA homologous to the Ala-Gly cleavage site of LexA.", "output": {"entities": {"gene": [{"text": "MucA", "start": 64, "end": 68}, {"text": "LexA", "start": 112, "end": 116}]}}, "schema": []}
{"input": "The latter was determined as follows: Type I-solid tumor tissue without significant peripheral isolated tumor cells; Type II-solid tumor tissue associated with peripheral isolated tumor cells; Type III-isolated tumor cells only.", "output": {"entities": {}}, "schema": []}
{"input": "The pharmacology of carnitine.", "output": {"entities": {}}, "schema": []}
{"input": "Acute inhalation toxicity of T-2 mycotoxin in mice.", "output": {"entities": {}}, "schema": []}
{"input": "The present investigation sought to identify the principal dimensions of the Framingham Type A scale (FTAS) and then to examine their physiological and psychological correlates.", "output": {"entities": {}}, "schema": []}
{"input": "A preliminary study on pyogenic arthritis.", "output": {"entities": {}}, "schema": []}
{"input": "Legionella, microbial ecology, and inconspicuous consumption.", "output": {"entities": {}}, "schema": []}
{"input": "Lymphatics in the aorta of rats treated with a soy-bean oil extract (lipofundin).", "output": {"entities": {}}, "schema": []}
{"input": "For signal durations less than 10 ms, however, the SoNo and S pi No threshold functions converged and the masking-level difference decreased.", "output": {"entities": {}}, "schema": []}
{"input": "The spleen rate of about 600 villagers of RK I examined was 54. 3% and the parasite rate 13. 2% before the drug intervention.", "output": {"entities": {}}, "schema": []}
{"input": "Multiple dosing four times daily for 7 days of indoprofen 200 mg, a non-steroidal anti-inflammatory drug with a short half-life (t1/2), revealed drug accumulation in eight elderly subjects.", "output": {"entities": {}}, "schema": []}
{"input": "In 10 patients with subacute cardiac tamponade, pulmonary wedge pressure (PWP), RAP, and IPP were measured along with indexes of systolic function.", "output": {"entities": {}}, "schema": []}
{"input": "Encompassing tamponade and pericardiocentesis data, left ventricular stroke work index showed positive correlation with TMFP1 (r =. 59) and TMFP2 (r =. 52) but not with TMFP3.", "output": {"entities": {}}, "schema": []}
{"input": "Rabbits developed profound hypocalcemia, with levels falling from 15. 5 +/-0. 2 to 7. 6 +/-0. 4 mg/dl under the influence of TSST-1.", "output": {"entities": {"gene": [{"text": "TSST-1", "start": 125, "end": 131}]}}, "schema": []}
{"input": "Similarly, actuarial interpretations for the second protocols were not more frequently selected by therapists as more valid, regardless of treatment condition and elevation of the F and F-K indices on the first MMPI profile.", "output": {"entities": {}}, "schema": []}
{"input": "The study disclosed generalized atrophy and diffuse symmetric white matter hypodensities.", "output": {"entities": {}}, "schema": []}
{"input": "The diagnosis of metachromatic leukodystrophy (MLD) was confirmed by the finding of low arylsulfatase A (ASA) levels in cultured fibroblasts in both sisters.", "output": {"entities": {"gene": [{"text": "arylsulfatase A", "start": 88, "end": 103}, {"text": "ASA", "start": 105, "end": 108}]}}, "schema": []}
{"input": "Drugs that are transformed via phase II reactions usually do not require dosage adjustment.", "output": {"entities": {}}, "schema": []}
{"input": "A study of human genes coding for U4 small nuclear RNA is presented.", "output": {"entities": {"gene": [{"text": "U4 small nuclear RNA", "start": 34, "end": 54}]}}, "schema": []}
{"input": "Using the balloon-gas procedure with a single gas injection, a bubble was obtained that was large enough to tamponade a giant tear without prior drainage of subretinal fluid or vitrectomy.", "output": {"entities": {}}, "schema": []}
{"input": "Development of a provisional information-retrieval descriptor language for \" Roentgenology and Medical Radiology \" for use in the Medinform system", "output": {"entities": {}}, "schema": []}
{"input": "Persistent acantholytic dermatosis with increased light sensitivity", "output": {"entities": {}}, "schema": []}
{"input": "Thus, a negative test is compatible with low disease activity and/or efficacy of calcium antagonist treatment.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, a negative test is compatible with low disease activity and/or efficacy of calcium antagonist treatment.", "output": {"entities": {}}, "schema": []}
{"input": "Dorsal foot TcpO2 was measured by using oxygen-sensing electrodes with surface temperatures of 42 degrees C and 45 degrees C; in theory, changes in sympathetic activity should affect vasomotor tone and TcpO2 in skin beneath an electrode at 42 degrees C (submaximal vasodilation), but not at 45 degrees C (maximal vasodilation).", "output": {"entities": {}}, "schema": []}
{"input": "In subjects (n = 5) with quadriplegia and reduced sympathetic tone secondary to cervical cord trauma, TcpO2 at 42 degrees C and vasodilation index were increased (45. 0 mmHg and 0. 61); TcpO2 at 45 degrees C did not change.", "output": {"entities": {}}, "schema": []}
{"input": "The other model was a continuous exponential plus constant of the form La-= a + b [exp (cVO2)].", "output": {"entities": {}}, "schema": []}
{"input": "Cell.", "output": {"entities": {}}, "schema": []}
{"input": "Timing of symptoms and oocyst excretion in human cryptosporidiosis.", "output": {"entities": {}}, "schema": []}
{"input": "After dopamine infusion in women with polycystic ovary syndrome and in matched controls, steady state levels of plasma dopamine, norepinephrine, and the ratio of dopamine/norepinephrine were similar in the two groups.", "output": {"entities": {}}, "schema": []}
{"input": "Diagnostic importance of determining the complement constituents in children with autoimmune thyroiditis", "output": {"entities": {}}, "schema": []}
{"input": "The 4 patients with carboxyhemoglobin levels in excess of 10% may represent occult carbon monoxide poisoning in this population.", "output": {"entities": {"gene": [{"text": "carboxyhemoglobin", "start": 20, "end": 37}]}}, "schema": []}
{"input": "All these processes were fully developed during the last month of pregnancy, offering the same picture as the controls.", "output": {"entities": {}}, "schema": []}
{"input": "Hypoglycemic action of \" he xiang zhuang qi gong \" and its mechanism on diabetes mellitus", "output": {"entities": {}}, "schema": []}
{"input": "This region of 60 amino acids may be involved in coiled-coil interactions similar to those that facilitate the filament formation in the rod region.", "output": {"entities": {}}, "schema": []}
{"input": "This approach enables the sources of error in the calculation of nutrient utilization to be readily identified, and their effect on precision to be assessed in different nutritional and metabolic states.", "output": {"entities": {}}, "schema": []}
{"input": "The effect of dietary zinc deficiency on the mossy fiber zinc content of the rat hippocampus.", "output": {"entities": {}}, "schema": []}
{"input": "Weaned rats were fed a normal diet or a low-protein, low-energy diet, and injected with saline or thyroxine (5 micrograms/100 g BW) for 22 days.", "output": {"entities": {}}, "schema": []}
{"input": "The effects of several opioid agonists and the opioid antagonist naloxone were examined in rats responding under a fixed-consecutive-number (FCN) schedule.", "output": {"entities": {}}, "schema": []}
{"input": "The rate-decreasing effects of morphine and U50488 were reversed completely by a 0. 01 and 1. 0 mg/kg dose of naloxone, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "An intralobar change in temperature above or below 36 degrees C decreases only the lobar bronchial blood flow and does not influence blood flow to other nearby tissues including those vascularized by the bronchial circulation.", "output": {"entities": {}}, "schema": []}
{"input": "Convulsive status epilepticus after infusion of cisplatin", "output": {"entities": {}}, "schema": []}
{"input": "The following markers were looked for in the serum, skin and liver of all patients with chronic hepatitis: HBV (HBs Ag and HBe Ag, anti-HBs, anti-HBe and anti-HBc in the serum, HBs and HBc Ag in the liver); non-A non-B (non-A, non-B Ag and antibody, anti non-A non-Bc in the serum, non-A, non-Bc Ag in the liver).", "output": {"entities": {"gene": [{"text": "HBs Ag", "start": 112, "end": 118}, {"text": "HBe Ag", "start": 123, "end": 129}, {"text": "anti-HBs", "start": 131, "end": 139}, {"text": "anti-HBe", "start": 141, "end": 149}, {"text": "anti-HBc", "start": 154, "end": 162}, {"text": "HBs and HBc Ag", "start": 177, "end": 191}, {"text": "non-A non-B", "start": 207, "end": 218}, {"text": "non-A, non-B Ag and antibody", "start": 220, "end": 248}, {"text": "anti non-A non-Bc", "start": 250, "end": 267}, {"text": "non-A, non-Bc Ag", "start": 282, "end": 298}]}}, "schema": []}
{"input": "Groups of male and female Fischer 344 rats, B6C3F1 mice, and Hartley guinea pigs were exposed once for 6 hr to mean concentrations of 10. 5, 5. 4, 2. 4, 1. 0, or 0 (control) ppm of methyl isocyanate (MIC) vapor.", "output": {"entities": {}}, "schema": []}
{"input": "Radionuclide study and endomyocardial biopsy revealed remarkable degeneration of myocardium.", "output": {"entities": {}}, "schema": []}
{"input": "Immobilization of the fracture in a collar and cuff sling was as effective as more elaborate methods.", "output": {"entities": {}}, "schema": []}
{"input": "Comparison of patients receiving phenytoin and those who were not showed significantly lower serum folate in the sub-group receiving phenytoin, but there was no significant difference between the sub-groups with respect to vitamin B12 or behaviour problem rating.", "output": {"entities": {}}, "schema": []}
{"input": "Typical and atypical clinical features of this lacrimal sac cyst are emphasized.", "output": {"entities": {}}, "schema": []}
{"input": "The role of saliva in sour taste perception was investigated in a series of 4 experiments.", "output": {"entities": {}}, "schema": []}
{"input": "Separate experiments measured AIB and 86RbCl uptake in 36B-10 cells in vitro 1 and 2 days following 20 Gy irradiation to assess whether this radiation dose reduced the capacity of tumor cells to trap AIB or Rb +.", "output": {"entities": {}}, "schema": []}
{"input": "For patients with recurrent or metastatic disease, the data suggest that I-131 MIBG scintigraphy is the examination of choice.", "output": {"entities": {}}, "schema": []}
{"input": "W.", "output": {"entities": {}}, "schema": []}
{"input": "Cyclosporine treatment for intractable polymyositis.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, on the Cohler' s maternal scale, Korean mothers were found to view their infants as more passive and dependent than American mothers did (P less than 0. 00).", "output": {"entities": {}}, "schema": []}
{"input": "A preoperative teaching booklet for pediatric patients.", "output": {"entities": {}}, "schema": []}
{"input": "Hyperthyroidism", "output": {"entities": {}}, "schema": []}
{"input": "We conclude that for mono-intronic precursors in which there is only one choice of splice sites, most of the exon sequences are not mechanistically involved in the splicing process.", "output": {"entities": {}}, "schema": []}
{"input": "UVA-induced melanocytic lesions.", "output": {"entities": {}}, "schema": []}
{"input": "Ex vivo MAO inhibition data indicated DPGPEA to be an inhibitor of MAO-B, although the effect was much weaker than seen with tranylcypromine or pargyline.", "output": {"entities": {"gene": [{"text": "MAO", "start": 8, "end": 11}, {"text": "MAO-B", "start": 67, "end": 72}]}}, "schema": []}
{"input": "Thus in this region of the vessel pyridinoline represents the major stabilising crosslink of collagen.", "output": {"entities": {"gene": [{"text": "collagen", "start": 93, "end": 101}]}}, "schema": []}
{"input": "A careful, radiolabelled tissue-distribution study is warranted to elucidate the complicated metabolic fate of perhexiline.", "output": {"entities": {}}, "schema": []}
{"input": "Systemic lupus erythematosus was diagnosed.", "output": {"entities": {}}, "schema": []}
{"input": "In the evening, the amplitude of the responses to both O2 and CO2 increased but the increase in CO2 sensitivity was proportionally more important.", "output": {"entities": {}}, "schema": []}
{"input": "The statistical significance of the prognosis factors was studied by uni-and multivariative methods, according to the model of Cox, with the help of an IMB computer.", "output": {"entities": {}}, "schema": []}
{"input": "These changes at the site of injection consist of a focal abnormality characterized by a slight increase in signal intensity on T1 weighted images and markedly increased signal intensity on T2 weighted images.", "output": {"entities": {}}, "schema": []}
{"input": "These results suggest that less antidopaminergic activity of RHAL in this neuroleptic test might be explained by the lesser conversion of RHAL to HAL.", "output": {"entities": {}}, "schema": []}
{"input": "Organisms were recovered from the conjunctiva for several weeks, and persistent genital and gastrointestinal infection also resulted from the ocular infection in some cats.", "output": {"entities": {}}, "schema": []}
{"input": "In vivo epiluminescence microscopy of pigmented skin lesions.", "output": {"entities": {}}, "schema": []}
{"input": "These equilibrium solutions are then shown to arise from the vertices of a particular convex polyhedron.", "output": {"entities": {}}, "schema": []}
{"input": "Statistically significant effects were noted at doses which did not appear to be maternally toxic.", "output": {"entities": {}}, "schema": []}
{"input": "Low MAO subjects showed a pattern of higher scores in KSP Impulsiveness, EPQ Neuroticism, and KSP Somatic Anxiety and Irritability and lower scores in KSP Socialization, in line with personality profiles found in alcoholics, psychopaths, and suicide attempters who also tend to have low platelet MAO activity.", "output": {"entities": {"gene": [{"text": "MAO", "start": 4, "end": 7}, {"text": "MAO", "start": 296, "end": 299}]}}, "schema": []}
{"input": "In group I, Paw, delta V, PaO2, Vinj and VT significantly decreased whereas operating pressure and E significantly increased when the internal diameter of the injector cannula was reduced.", "output": {"entities": {}}, "schema": []}
{"input": "In calves receiving milk-substitute diets containing 80-260 g DM/kg, milk intakes were reduced by up to 30% on the 1st day that calves were fed once daily instead of twice daily.", "output": {"entities": {}}, "schema": []}
{"input": "Today there is no doubt that elevated plasma cholesterol levels should be lowered first by dietary modification even in early childhood, beginning at the age of two years.", "output": {"entities": {}}, "schema": []}
{"input": "These results suggest that N-nitroso compounds can be formed in vivo in the infected bladder, which could explain the association between urinary-tract infections and increased risk for bladder cancer.", "output": {"entities": {}}, "schema": []}
{"input": "Epithelial nerve fiber defects included absence or distorted architecture of the basal epithelial plexus and intra-epithelial terminals.", "output": {"entities": {}}, "schema": []}
{"input": "The histologic grade for the same anatomic site varied among hearts and among different anatomic sites in the same heart.", "output": {"entities": {}}, "schema": []}
{"input": "Serum levels of albumin, globulin, and coagulation protein activity were measured preshock, postshock, and daily for 3 days; skin lymph levels were measured on Day 3.", "output": {"entities": {"gene": [{"text": "albumin", "start": 16, "end": 23}, {"text": "globulin", "start": 25, "end": 33}, {"text": "coagulation protein", "start": 39, "end": 58}]}}, "schema": []}
{"input": "For colostral milk there was a significant correlation of vitamin K1 to cholesterol (r = 0. 62) but not to total lipid or phospholipid suggesting a role for cholesterol in the secretion of vitamin K1 into colostral milk.", "output": {"entities": {}}, "schema": []}
{"input": "Endurance training resulted in an increase of stiffness associated with a decrease of type II fibers.", "output": {"entities": {}}, "schema": []}
{"input": "A rate-decreasing dose of physostigmine, an acetylcholinesterase inhibitor, was studied in combination with the range of atropine doses.", "output": {"entities": {"gene": [{"text": "acetylcholinesterase", "start": 44, "end": 64}]}}, "schema": []}
{"input": "References for occupational fitness of adolescents with diseases of the respiratory tract and lungs", "output": {"entities": {}}, "schema": []}
{"input": "Salzburg, 9-12 September 1987.", "output": {"entities": {}}, "schema": []}
{"input": "Two new glucosidase inhibitors (BAY m 1099 and BAY o 1248) were studied in volunteers and type II diabetics under various conditions.", "output": {"entities": {"gene": [{"text": "glucosidase", "start": 8, "end": 19}]}}, "schema": []}
{"input": "The models accurately localized the common boundaries between the PBB and CN.", "output": {"entities": {}}, "schema": []}
{"input": "However, conversions of 12 mm or more from a documented negative result indicated spread of infection.", "output": {"entities": {}}, "schema": []}
{"input": "The maximum amplitude of evoked responses in the cervical sympathetic trunk was obtained when the T2 white ramus was stimulated and decreased gradually when followed by the stimulation of T1, T3, T4 and T5 white rami.", "output": {"entities": {}}, "schema": []}
{"input": "It is concluded that contact allergy to K-CG is common.", "output": {"entities": {}}, "schema": []}
{"input": "The effect of a beta-adrenoceptor antagonist, pindolol, on uterine smooth muscle in term pregnant women was studied in vitro and in vivo (in hypertensive women).", "output": {"entities": {"gene": [{"text": "beta-adrenoceptor", "start": 16, "end": 33}]}}, "schema": []}
{"input": "The less-polar mycolic acid-containing Rhodococcus species showed chromatographic patterns that partially overlapped (in elution times) the patterns of Nocardia asteroides, N. otitidiscaviarum, and N. brasiliensis, but the larger number of peaks in the last species made separation between the genera possible.", "output": {"entities": {}}, "schema": []}
{"input": "Blood serum erythropoietin level and basic hematological indices during the adaptation of healthy newborn infants", "output": {"entities": {"gene": [{"text": "Blood serum erythropoietin", "start": 0, "end": 26}]}}, "schema": []}
{"input": "49, XXXXY chromosome anomaly: an unusual variant of Klinefelter' s syndrome.", "output": {"entities": {}}, "schema": []}
{"input": "Oxygen delivery and consumption and P50 in patients with acute myocardial infarction.", "output": {"entities": {}}, "schema": []}
{"input": "Infants of this sample had monocular PL visual acuities similar to those established by McDonald et al. in a laboratory setting.", "output": {"entities": {}}, "schema": []}
{"input": "These results indicate that the effect of the isomers of pentobarbital and secobarbital on mult FR30 FI600 responding and on suppressed responding are qualitatively similar. (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {}}, "schema": []}
{"input": "The number of crystalline deposits is less in the advanced atrophic areas of the RPE-choriocapillaris complex.", "output": {"entities": {}}, "schema": []}
{"input": "All 33 subjects were given psychometric instruments for measuring various components of anger and anxiety: Spielberger' s State-Trait Personality Inventory, the Anger Expression Scale, and the State Anger Reaction Scale.", "output": {"entities": {}}, "schema": []}
{"input": "It was found that the primary visual cortex of the rat is asymmetrical in volume, and that the asymmetry reflects side differences in the number of neurons.", "output": {"entities": {}}, "schema": []}
{"input": "The subjects received a single 500 mg dose of acetaminophen i. v. and concentrations in plasma were measured for 360 minutes and in urine for 24 h in order to estimate the production of metabolites.", "output": {"entities": {}}, "schema": []}
{"input": "Mean weighted skin temperature (Tsk) was lower (P less than 0. 01) following acclimation than before, and acclimation resulted in a larger (P less than 0. 02) Tre-to-Tsk gradient.", "output": {"entities": {}}, "schema": []}
{"input": "Indium-111 leukocyte imaging in patients with rheumatoid arthritis.", "output": {"entities": {}}, "schema": []}
{"input": "The effect of L-methionine supplementation on the utilization of a soy protein isolate (SPI) was evaluated by short-term nitrogen balance studies in young women.", "output": {"entities": {}}, "schema": []}
{"input": "Primary invasive Haemophilus influenzae type b disease: a population-based assessment of risk factors.", "output": {"entities": {}}, "schema": []}
{"input": "Overall, lesions infiltrating the deep lamina propria do not exhibit a reduced frequency of occurrence compared to lesions infiltrating the skeletal muscle; however, carcinomas affecting other oral sites showed a reduced frequency of deeply infiltrating lesions in comparison to more superficial lesions.", "output": {"entities": {}}, "schema": []}
{"input": "Factors that showed significant correlation to elevated CIC' s in the highly elevated portion of our CIC population were poor NIH score, increased patient age, low peak expiratory flow rate, and elevated total serum IgG.", "output": {"entities": {"gene": [{"text": "serum IgG", "start": 210, "end": 219}]}}, "schema": []}
{"input": "Induction of both potential transcripts follows heat shock in vivo.", "output": {"entities": {}}, "schema": []}
{"input": "New and successful steps have been made in immunodiagnostics, immunotherapy, and immunoprophylaxis of immunologically conditioned infertility.", "output": {"entities": {}}, "schema": []}
{"input": "Estimated nucleic acid N absorption is 7-8% of N intake.", "output": {"entities": {}}, "schema": []}
{"input": "Adhesion, phagocytosis, chemotactic and random migration, nitroblue tetrazolium dye reduction of peritoneal exudate neutrophils and macrophages, fibrinogen level, gelation of soluble fibrin and serial dilution protamine sulfate test were investigated in 115 New Zealand white rabbits with experimentally induced Shwartzman phenomenon in the colon, and in control animals.", "output": {"entities": {"gene": [{"text": "fibrinogen", "start": 145, "end": 155}, {"text": "fibrin", "start": 183, "end": 189}]}}, "schema": []}
{"input": "The FFA levels were not affected (P greater than. 1) by meal interval.", "output": {"entities": {}}, "schema": []}
{"input": "He visited our hospital and left solitary renal cyst was suspected.", "output": {"entities": {}}, "schema": []}
{"input": "However, further analyses of the data indicate that increasing VO2 AT (r =-0. 63, P less than 0. 05) rather than VO2max (r =-0. 15) could result in improving the 10, 000 m race performance to a larger extent, and that the absolute amount of change (delta) in the 10, 000 m run time is best accounted for by a combination of delta VO2 AT and delta 5, 000 m run time.", "output": {"entities": {}}, "schema": []}
{"input": "A significant herd X period interaction existed for liver TG and serum dextran precipitable cholesterol concentrations.", "output": {"entities": {}}, "schema": []}
{"input": "Liver TG and serum NEFA concentrations were positively correlated.", "output": {"entities": {}}, "schema": []}
{"input": "The results show that nerve and roots differ considerably both in the force they sustain before failure and in the other biomechanics they exhibit.", "output": {"entities": {}}, "schema": []}
{"input": "When the coronary sinus pressure reached 15 torr, there was a significant decrease in cardiac index (3. 60 +/-0. 5 to 2. 70 +/-0. 6 L/min/m2, p less than 0. 001), coronary blood flow (13. 7 +/-3. 1 to 7. 0 +/-2. 1 ml/min, p less than 0. 001), rate of rise of left ventricular pressure (1, 567 +/-275 to 1, 331 +/-314, p less than 0. 05), and an increase in coronary arteriovenous difference (62. 8% +/-9. 3% to 70. 5% +/-5. 4% saturation, p less than 0. 03).", "output": {"entities": {}}, "schema": []}
{"input": "Calcifications in the thoracic aorta at the level of the 11th and the 12th thoracic vertebrae in 592 men and 333 women were studied using computed tomography.", "output": {"entities": {}}, "schema": []}
{"input": "In a series of 402 consecutive autopsies, parietal pleural plaques (PP) were found in 68 individuals above 40 years of age.", "output": {"entities": {}}, "schema": []}
{"input": "Approximately 60% of cell bodies of primary neurons innervating the intra and perioral structures through the inferior alveolar, lingual, mental, and buccal nerves were in the range between 300 and 600 micron 2 in cross-sectional area: mean +/-SD 509 +/-243 micron 2, 420 +/-181 micron 2, 469 +/-200 micron 2, and 444 +/-186 micron 2, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Pharmacological action of eptazocine (l-1, 4-dimethyl-10-hydroxy-2, 3, 4, 5, 6, 7-hexahydro-1, 6-methano-1H-4-benz azonine).", "output": {"entities": {}}, "schema": []}
{"input": "On transition from high to low voltage there was a significant fall in arterial pressure (7%) and an increase in flow (19-38%) to areas of the brain corresponding to the arborization of the reticular formation, i. e. excluding the cerebrum and cerebellum.", "output": {"entities": {}}, "schema": []}
{"input": "One hundred and four (14 per cent) second primary tumours were reported.", "output": {"entities": {}}, "schema": []}
{"input": "Failures of colorimetric additivity under these experimental conditions are discussed.", "output": {"entities": {}}, "schema": []}
{"input": "There have been five problems (extravasation 2, suspected sepsis 1, and hematoma 2) during a total of 2, 927 days of exposure.", "output": {"entities": {}}, "schema": []}
{"input": "It is suggested that these results may raise the interesting possibility of providing a means of identifying greater or lesser susceptibility to the coronary effects of Type A behavior.", "output": {"entities": {}}, "schema": []}
{"input": "Two studies assessed two types of reliability of the student Jenkins Activity Survey (JAS; a questionnaire measure of Type A behavior).", "output": {"entities": {}}, "schema": []}
{"input": "When phencyclidine was administered alone, overall response rate decreased and percent errors increased with increasing doses.", "output": {"entities": {}}, "schema": []}
{"input": "Possibilities and outlook for wrist joint endoprosthesis", "output": {"entities": {}}, "schema": []}
{"input": "Study of the energy metabolism of the sensomotor cortex and hippocampus by the (14C) 2-deoxyglucose method during the development of dissociated states", "output": {"entities": {}}, "schema": []}
{"input": "Malignant lymphoma is very heterogeneous in terms of its biological behavior.", "output": {"entities": {}}, "schema": []}
{"input": "Further investigations are necessary to elucidate the biochemical and physiological properties of DLIS.", "output": {"entities": {}}, "schema": []}
{"input": "Among them, 26 cases were benign and 34 malignant.", "output": {"entities": {}}, "schema": []}
{"input": "Of the cases with PLD, 50% had associated renal cysts and 10% of the cases with APCD had associated liver cysts.", "output": {"entities": {}}, "schema": []}
{"input": "Fast goal-directed voluntary movements of the human upper extremity are known to be associated with three distinct bursts of EMG activity in antagonistic muscles.", "output": {"entities": {}}, "schema": []}
{"input": "The combination of F1 and F2 which was the best predictor of CHD in this population (G1) might be interpreted as reflecting trunk adiposity mainly abdominal.", "output": {"entities": {}}, "schema": []}
{"input": "Renal clearance fell from 19. 0 +/-4. 9 ml/min/1. 73 m2 (group I) to 1. 0 +/-0. 4 ml/min/1. 73 m2 (group IV).", "output": {"entities": {}}, "schema": []}
{"input": "The relations between type A behavior, clinically relevant behavior, academic achievement, and IQ in children.", "output": {"entities": {}}, "schema": []}
{"input": "She also had slight weakness of the upper extremities.", "output": {"entities": {}}, "schema": []}
{"input": "Results of electron therapy of tumors in different sites", "output": {"entities": {}}, "schema": []}
{"input": "The mechanism of action is explored in some detail, specifically as it relates to reticuloendothelial system (RES) Fc receptor blockade and suppression of antiplatelet antibody synthesis.", "output": {"entities": {"gene": [{"text": "Fc receptor", "start": 115, "end": 126}]}}, "schema": []}
{"input": "Incidences of nonfatal stroke, myocardial infarction, angina pectoris und left ventricular hypertrophy could also be lowered.", "output": {"entities": {}}, "schema": []}
{"input": "High radial r values with small standard deviations were observed in normal LV (0. 972 +/-0. 016) and in non-MI regions (0. 964 +/-0. 018), indicating temporally homogeneous radial shortening.", "output": {"entities": {}}, "schema": []}
{"input": "These results indicate that during pregnancy there are increases in bone formation rates contributing to the increases in skeletal mass.", "output": {"entities": {}}, "schema": []}
{"input": "We analyzed data from 56 patients with Systemic Lupus Erythematosus (SLE) in whom renal biopsies were done systematically.", "output": {"entities": {}}, "schema": []}
{"input": "Prevention by a heparin-antithrombin III combination", "output": {"entities": {"gene": [{"text": "antithrombin III", "start": 24, "end": 40}]}}, "schema": []}
{"input": "MICs of four antifungal agents (5-fluorocytosine, miconazole, ketoconazole, and amphotericin B) for 84 clinical isolates of various Candida species were then determined with both media in agar dilution and microtiter broth dilution systems.", "output": {"entities": {}}, "schema": []}
{"input": "There were 18 patients with Group II (a) tumors; although tumor biopsy was attempted on eight of these, pathological diagnosis at the time of surgery was made in only one case.", "output": {"entities": {}}, "schema": []}
{"input": "Evidence that opiate addiction is in part an immune response.", "output": {"entities": {}}, "schema": []}
{"input": "Parasitological post-mortem examination of all seropositive animals showed five and seven false-positive animals when E/S and CWE antigens were used, respectively.", "output": {"entities": {"gene": [{"text": "E/S and CWE antigens", "start": 118, "end": 138}]}}, "schema": []}
{"input": "Glucocorticoid induced hypertension has been regarded as independent of sodium (Na), in contrast to mineralocorticoid induced hypertension, which is Na +-dependent.", "output": {"entities": {}}, "schema": []}
{"input": "Seventeen of them were on treatment with systemic steroids.", "output": {"entities": {}}, "schema": []}
{"input": "Examples of its use in the intensive therapy unit are described.", "output": {"entities": {}}, "schema": []}
{"input": "Only seven patients, five of whom have metastatic disease, survive more than 10 years after first presentation; nine patients, one of whom has secondaries, survive for 5 years or less.", "output": {"entities": {}}, "schema": []}
{"input": "Although differences were not significant, infants in the experimental group had more changes in the intermittent mandatory ventilation (IMV) settings during transport, and more such infants arrived at the receiving hospital with acceptable pH and PCO2 values.", "output": {"entities": {}}, "schema": []}
{"input": "Repetitive sequences are present in at least three introns of the cytochrome P-450PBc2 gene, but not in exons or the 5'-flanking region.", "output": {"entities": {"gene": [{"text": "cytochrome P-450PBc2 gene", "start": 66, "end": 91}]}}, "schema": []}
{"input": "A large increase of serum ketones occurred under all conditions, and the exercise respiratory quotient suggested some increase of fat utilization, WW (0. 85) through CW (0. 84) to CC (0. 83).", "output": {"entities": {}}, "schema": []}
{"input": "This lack of correlation may be due to variations in the metabolic activity of the endometriotic implants present at different stages of the disease.", "output": {"entities": {}}, "schema": []}
{"input": "Respiratory adaptation to chronic hypoxia in newborn rats.", "output": {"entities": {}}, "schema": []}
{"input": "Compound 1 is either 21-O-angeloyl, 22-O-tigloyl R1-barrigenol, or 21-O-tigloyl, 22-O-angeloyl R1-barrigenol.", "output": {"entities": {}}, "schema": []}
{"input": "Human and Chinese hamster S14 protein sequences deduced from the cDNAs are identical.", "output": {"entities": {"gene": [{"text": "Chinese hamster S14 protein sequences", "start": 10, "end": 47}]}}, "schema": []}
{"input": "RPS14 introns 3 and 4 both contain Alu sequences.", "output": {"entities": {"gene": [{"text": "RPS14", "start": 0, "end": 5}, {"text": "Alu", "start": 35, "end": 38}]}}, "schema": []}
{"input": "One of the most relevant aspects in achieving the consistent survival of an animal undergoing the experimental implantation of a total artificial heart is obviously related to the correct anatomic placement of prosthetic ventricles inside the chest.", "output": {"entities": {}}, "schema": []}
{"input": "An exaggerated tissue response adjacent to the cyanoacrylate site suggested a potential toxic chemical or thermal reaction, or both, to the tissue adhesive, but there was no evidence of any distant ocular effects.", "output": {"entities": {}}, "schema": []}
{"input": "These findings suggest that there may be a relationship between the pathogenesis of MAL, narcolepsy, and OSA.", "output": {"entities": {}}, "schema": []}
{"input": "Among 82 superficial lesions 34 were classified as showing CR and another 23 as showing PR, with a response rate of 69. 5%.", "output": {"entities": {}}, "schema": []}
{"input": "While the examiner observed the interior of the eye with indirect ophthalmoscopy, the point source of light from the fiberoptic light pipe was moved along the margins of the episcleral plaque.", "output": {"entities": {}}, "schema": []}
{"input": "These fusion proteins also allowed the localization of the transcriptional activation and DNA binding domains of the ToxR protein to its cytoplasmically located N-terminal portion.", "output": {"entities": {"gene": [{"text": "ToxR protein", "start": 117, "end": 129}]}}, "schema": []}
{"input": "From life-table analyses of these patients, we estimated that the incidence of secondary chondrosarcoma in patients who have Ollier disease is about 25 per cent at the age of forty years, and that malignant degeneration is almost a certainty in patients who have Maffucci syndrome.", "output": {"entities": {}}, "schema": []}
{"input": "The lethal toxicity of inorganic (HgCl2) and organic (CH3HgCl) mercury chloride was compared for Coturnix (Japanese quail, Coturnix japonica) of different ages from hatch through adulthood by single-dose acute oral and intramuscular injections and by a 5-d dietary trial.", "output": {"entities": {}}, "schema": []}
{"input": "Since the integrated 13h00-16h00 plasma cortisol estimation is cheaper and simpler than the mean 13h00-16h00 plasma cortisol estimation, we recommend it as an adjunct in the diagnosis of Cushing' s syndrome.", "output": {"entities": {}}, "schema": []}
{"input": "Most of the patients had locally advanced lesions (63 T3-4: 91. 5%) according to the adopted TNM system (Lederman-Gadeberg, Sisson-Jesse).", "output": {"entities": {}}, "schema": []}
{"input": "Chlorambucil and interferon for low grade non-Hodgkin' s lymphoma.", "output": {"entities": {"gene": [{"text": "interferon", "start": 17, "end": 27}]}}, "schema": []}
{"input": "Selenium (. 1 ppm) and E (50 IU/kg) supplementation of the diet of the sow increased plasma tocopherol and Se concentrations, but did not increase plasma glutathione peroxidase (GSH-Px) activity.", "output": {"entities": {"gene": [{"text": "plasma glutathione peroxidase", "start": 147, "end": 176}, {"text": "GSH-Px", "start": 178, "end": 184}]}}, "schema": []}
{"input": "Framingham Type A behavior was positively associated with diastolic blood pressure (r = 0. 17, p less than 0. 05) among the women.", "output": {"entities": {}}, "schema": []}
{"input": "The in vitro antibacterial potency is greatest when the 1-substituent is 2, 4-difluorophenyl and the 7-substituent is a 3-amino-1-pyrrolidinyl group.", "output": {"entities": {}}, "schema": []}
{"input": "The M reading frame differed from the reported sequence by a single nucleotide corresponding to a conservative lysine to arginine amino acid substitution near the carboxy-terminus conserved among the M proteins of paramyxoviruses.", "output": {"entities": {"gene": [{"text": "M reading frame", "start": 4, "end": 19}, {"text": "M proteins", "start": 200, "end": 210}]}}, "schema": []}
{"input": "An ion chromatographic method was used to determine Br ion in the urine of Greyhounds.", "output": {"entities": {}}, "schema": []}
{"input": "II.", "output": {"entities": {}}, "schema": []}
{"input": "Laryngographic changes following endotracheal intubation in adults.", "output": {"entities": {}}, "schema": []}
{"input": "Autotransplantation of a vein segment with valve in the treatment of deep vein valvular insufficiency of the lower extremity", "output": {"entities": {}}, "schema": []}
{"input": "The relationships among four descriptors of lactate increase: lactate threshold (LT) (the VO2 at which blood lactate concentration begins to increase above the resting level during an incremental exercise test), LT1 (the VO2 at which blood lactate increases 1 mM above the resting level), LT2 (the VO2 at which blood lactate concentration reaches a fixed value of 2 mM), onset of blood lactate accumulation (OBLA; the VO2 at which blood lactate reaches a concentration of 4 mM), were compared with aerobic capacity (VO2max) and 12 min running performance in 19 untrained female students.", "output": {"entities": {}}, "schema": []}
{"input": "This is based on partitioning an underlying multivariate normal distribution.", "output": {"entities": {}}, "schema": []}
{"input": "The observation of late effects after irradiations or after space flights show the difficulties encountered in assessing radiative risks during long duration space flights.", "output": {"entities": {}}, "schema": []}
{"input": "Practical use and interpretation of viral hepatitis B markers and hepatic biopsy in HBs Ag carriers and at the chronic hepatitis stage", "output": {"entities": {"gene": [{"text": "HBs Ag", "start": 84, "end": 90}]}}, "schema": []}
{"input": "The 1, 2, 3 and 4 year survival rates were 94%, 84%, 76% and 63%, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Northern blotting with a unique 17-mer oligonucleotide demonstrated the absence of the mutant sequence in the mRNA from which the cDNA library giving rise to the mutant cDNA was constructed.", "output": {"entities": {}}, "schema": []}
{"input": "Chemotherapy of metastasizing breast cancer", "output": {"entities": {}}, "schema": []}
{"input": "In recent years, successful physiological models have been developed for a variety of volatile and nonvolatile chemicals, and their ability to perform the extrapolations needed in risk assessment has been demonstrated.", "output": {"entities": {}}, "schema": []}
{"input": "Linear extrapolation is used below the experimental data range to establish an upper bound on carcinogenic risk at low doses.", "output": {"entities": {}}, "schema": []}
{"input": "Hisako Minowa who has worked as a psychiatric counsellor in industry for the past 20 years", "output": {"entities": {}}, "schema": []}
{"input": "Deletion mapping studies revealed that the upstream DNA sequences up to-86 were sufficient for the optimal basal level transcription in HeLa cells and also for the EIA-induced transcription.", "output": {"entities": {"gene": [{"text": "EIA", "start": 164, "end": 167}]}}, "schema": []}
{"input": "Incorporation of the polyene antibiotic amphotericin B (AMB) in liposomes results in a marked reduction in drug toxicity with no loss of antifungal potency.", "output": {"entities": {}}, "schema": []}
{"input": "Eleven healthy, normotensive males undergoing routine restorative dental care were evaluated during treatment for possible hemodynamic alterations in response to potential sympathetic nervous system stimulation.", "output": {"entities": {}}, "schema": []}
{"input": "Serum IgM and IgE concentrations, allergen-specific IgE scores, and the tumor E2R status were combined to construct a three-level risk classification that was more prognostic than any of the individual components.", "output": {"entities": {"gene": [{"text": "Serum IgM", "start": 0, "end": 9}, {"text": "IgE", "start": 14, "end": 17}, {"text": "allergen-specific IgE", "start": 34, "end": 55}, {"text": "E2R", "start": 78, "end": 81}]}}, "schema": []}
{"input": "Within the Strep. mutans group there was a highly-significant difference between Strep. mutans/Strep. cricetus (p less than 0. 01) with respect to mean clump size.", "output": {"entities": {}}, "schema": []}
{"input": "These results indicate that T. C., LDL-C., HDL-C., HDL2-C., apo B, apo A-I/B ratio and apo A-II/B ratio are predictive risk factors of the coronary heart disease.", "output": {"entities": {"gene": [{"text": "LDL-C", "start": 35, "end": 40}, {"text": "HDL-C", "start": 43, "end": 48}, {"text": "HDL2-C", "start": 51, "end": 57}, {"text": "apo B", "start": 60, "end": 65}, {"text": "apo A-I/B", "start": 67, "end": 76}, {"text": "apo A-II/B", "start": 87, "end": 97}]}}, "schema": []}
{"input": "It is concluded that the unique suppository formulation of CZX-S is useful in the treatment of infections in children with heavy psychophysiologic disorders and in children who cannot take oral drugs because of severe vomiting.", "output": {"entities": {}}, "schema": []}
{"input": "Single photon emission computerized tomography (SPECT), by providing three-dimensional representation of myocardial Tl-201, offers promise for improved localization of CAD.", "output": {"entities": {}}, "schema": []}
{"input": "Computer assisted mapping in quantitative analysis of cerebral positron emission tomograms.", "output": {"entities": {}}, "schema": []}
{"input": "Documentation of a successful intrauterine fertilization with delivery of a term baby supports the theoretical feasibility of the EP; however, anovulation incurred by our procedure appears to be the major drawback.", "output": {"entities": {}}, "schema": []}
{"input": "MRI disclosed one or more of the following abnormalities in 24 (63%) of 38 treated kidneys: (1) loss of corticomedullary differentiation, (2) perirenal fluid, (3) subcapsular hematoma, (4) hemorrhage into a renal cyst, and (5) unexplained abnormalities.", "output": {"entities": {}}, "schema": []}
{"input": "The results obtained are similar to those described with the previous Cremophor formulation although greater variability in induction and recovery times was noted with the emulsion formulation.", "output": {"entities": {}}, "schema": []}
{"input": "The percentage RFR reduction at the end of CPB showed significant correlation with 1) CPB duration (r = 0. 49), 2) oxygen flow rate index (OFRI), i. e. flow/min in the bubble oxygenator/m2 bsa (r = 0. 38), and 3) blood flow rate index (BFRI), i. e. average volume of blood pumped through the heart-lung machine/min CPB time/m2 bsa (r = 0. 51).", "output": {"entities": {}}, "schema": []}
{"input": "Diagnosis of unilateral renal artery lesions after captopril administration.", "output": {"entities": {}}, "schema": []}
{"input": "A retrospective study of banked sera from 19 cats with the eosinophilic granuloma complex revealed that 68% of affected cats had circulating antibodies to components of normal cat epithelium.", "output": {"entities": {}}, "schema": []}
{"input": "In memory of Magdelaine Comtesse", "output": {"entities": {}}, "schema": []}
{"input": "These results suggest that indoramin may have Class III antiarrhythmic activity.", "output": {"entities": {}}, "schema": []}
{"input": "A high efficacy of the combined use of nontoxic doses of two pharmaceuticals: cystamine (50 mg/kg) and mexamine (25 mg/kg) under the conditions of short-term exogenous hypoxia (7. 5% O2) was found in (CBA X C57Bl) F1 mice.", "output": {"entities": {}}, "schema": []}
{"input": "The Mean was 74, 3 +/-53, 6 micrograms J/g Cr, the Median 61 micrograms J/g Cr.", "output": {"entities": {}}, "schema": []}
{"input": "In the region Walgau with mixed industrial-rural population an iodine deficiency I was found in 81% and an iodine deficiency II in 45%.", "output": {"entities": {}}, "schema": []}
{"input": "The structural gene for hydrogenase encodes a protein product of molecular mass 45820 Da.", "output": {"entities": {"gene": [{"text": "hydrogenase", "start": 24, "end": 35}]}}, "schema": []}
{"input": "Pancreaticoduodenal lymph node enlargement, regardless of cause, has been a source of imaging confusion because of its propensity to mimic pancreatic malignancy yet not cause biliary obstruction.", "output": {"entities": {}}, "schema": []}
{"input": "Interference with rheumatoid factor was only observed in the ELISA enzygnost if sera were not pretreated with latex adsorbents.", "output": {"entities": {"gene": [{"text": "rheumatoid factor", "start": 18, "end": 35}]}}, "schema": []}
{"input": "All patients had elevated levels of serum IgE antibodies to the crude soybean extract; binding values ranged from 2. 3 to 28. 1 times that of a negative control serum.", "output": {"entities": {"gene": [{"text": "serum IgE antibodies", "start": 36, "end": 56}]}}, "schema": []}
{"input": "New techniques for the mass spectrometry of natural products.", "output": {"entities": {}}, "schema": []}
{"input": "Dual radionuclide subtraction imaging of the spleen using 67Ga citrate and 99mTc is useful in further delineating lesions that are identified on either a routine radiogallium survey or on a conventional sulfur colloid liver-spleen image.", "output": {"entities": {}}, "schema": []}
{"input": "Nursing education--the computer obligation.", "output": {"entities": {}}, "schema": []}
{"input": "Shear bond strength of a composite resin to an etched glass ionomer.", "output": {"entities": {}}, "schema": []}
{"input": "An additional advantage is that the resin can be removed and the immunoperoxidase technique carried out on thin sections.", "output": {"entities": {"gene": [{"text": "immunoperoxidase", "start": 65, "end": 81}]}}, "schema": []}
{"input": "Such a concept is crucial to our understanding of the pathology of ageing in general.", "output": {"entities": {}}, "schema": []}
{"input": "We consider that DIL-CP is a safe and excellent CP in CABG surgery and we are now utilizing this CP in all patients requiring CABG surgery.", "output": {"entities": {}}, "schema": []}
{"input": "We have earlier evolved an experimental model by means of which changes identical to the microembolism syndrome can be induced from a reproducible musculo-skeletal trauma in pigs observed under long-term anesthesia under standardized conditions.", "output": {"entities": {}}, "schema": []}
{"input": "Although no statistical significance was achieved, it is remarkable that there was a clear trend for the superiority of Galphimia D6 while the Galphimia dilution 10 (-6) was about equally effective compared with placebo.", "output": {"entities": {}}, "schema": []}
{"input": "The volume of blood to the flap ranges from 1 to 2 ml/min, collateral circulation to the flap exists, but is negligible, and there is little change in the capillary blood flow as the flap ages.", "output": {"entities": {}}, "schema": []}
{"input": "With aging, many aspects of immune function change.", "output": {"entities": {}}, "schema": []}
{"input": "Oral candidiasis", "output": {"entities": {}}, "schema": []}
{"input": "In addition, the gcd1-101 mutation suppressed the low translational efficiency of GCN4-lacZ mRNA observed in gcn2-and gcn3-cells.", "output": {"entities": {"gene": [{"text": "gcd1-101 mutation", "start": 17, "end": 34}, {"text": "GCN4", "start": 82, "end": 86}, {"text": "lacZ", "start": 87, "end": 91}, {"text": "gcn2-", "start": 109, "end": 114}, {"text": "gcn3-", "start": 118, "end": 123}]}}, "schema": []}
{"input": "This suggests that alaproclate acutely increases the responsiveness of postsynaptic muscarinic and alpha 1 adrenoceptors.", "output": {"entities": {"gene": [{"text": "muscarinic and alpha 1 adrenoceptors", "start": 84, "end": 120}]}}, "schema": []}
{"input": "The distribution of patients was as follows: group 1--complex gamma-therapy (55 cases), group 2--complex gamma-therapy plus iliac lymphadenectomy (50 cases) and group 3--complex radiation treatment with megavolt bremsstrahlung beam from the luc type installation and iliac lymphadenectomy (50 cases).", "output": {"entities": {}}, "schema": []}
{"input": "The availability of cryoprecipitate and DDAVP offers an alternative and effective treatment for the temporary reversal of uremic bleeding in patients who require urgent invasive procedures.", "output": {"entities": {}}, "schema": []}
{"input": "Thrombophlebitis and pulmonary embolism in congenital factor XII deficiency", "output": {"entities": {"gene": [{"text": "factor XII", "start": 54, "end": 64}]}}, "schema": []}
{"input": "Biopsies of the jejunal mucosa have shown abnormal enzyme activity or deficiencies in transport mechanisms.", "output": {"entities": {}}, "schema": []}
{"input": "Laboratory pyrolyses have indeed shown that PCBs give significant yields of PCDFs, and chlorobenzenes give both PCDFs and PCDDs.", "output": {"entities": {}}, "schema": []}
{"input": "A significant degree of homology was also found among these genes and the Mtase gene of related phage SPR, which codes for an enzyme with different modification specificity.", "output": {"entities": {"gene": [{"text": "Mtase gene", "start": 74, "end": 84}]}}, "schema": []}
{"input": "In a blind controlled trial, 15 patients with COCM (NYHA II-III) with sinus rhythm and a left ventricular ejection fraction (LV-EF) of 34. 5 +/-2. 6% received consecutively D (0. 25-0. 5 mg/d), placebo (PLAC), P (slow releases = SR) (80 mg/d SR) and both drugs combined in respective doses.", "output": {"entities": {}}, "schema": []}
{"input": "Mild orbital discomfort occurred in some patients.", "output": {"entities": {}}, "schema": []}
{"input": "The sample is deproteinized and after centrifugation valproic acid in the supernatant is measured in the free form by direct injection into the gas chromatograph.", "output": {"entities": {}}, "schema": []}
{"input": "Changes in muscarinic acetylcholine receptors in guinea-pig lung: effects of aging, inhalation of an allergen, administration of drugs, and vagotomy.", "output": {"entities": {"gene": [{"text": "muscarinic acetylcholine receptors", "start": 11, "end": 45}]}}, "schema": []}
{"input": "In the absence of other stabilizers, increased sucrose can provide increased thermoresistance to the virus in 2. 5% albumin.", "output": {"entities": {"gene": [{"text": "albumin", "start": 116, "end": 123}]}}, "schema": []}
{"input": "The overall prevalence of psoriasis was 4. 79% in men and 4. 85% in women.", "output": {"entities": {}}, "schema": []}
{"input": "Greek classicism in living structure? Some deductive pathways in animal morphology.", "output": {"entities": {}}, "schema": []}
{"input": "The possible origin and role of CSF prolactin are discussed.", "output": {"entities": {"gene": [{"text": "CSF prolactin", "start": 32, "end": 45}]}}, "schema": []}
{"input": "Three chromosomal crsA mutations, crsA1, crsA4, and crsA47, were transferred by the \" gene conversion \" process to B. subtilis plasmid pRPD11, which consists of the entire wild-type rpoD coding sequence, encoding the major sigma 43 factor of B. subtilis RNA polymerase, and pUB110.", "output": {"entities": {"gene": [{"text": "chromosomal crsA mutations", "start": 6, "end": 32}, {"text": "crsA1", "start": 34, "end": 39}, {"text": "crsA4", "start": 41, "end": 46}, {"text": "crsA47", "start": 52, "end": 58}, {"text": "wild-type rpoD coding sequence", "start": 172, "end": 202}, {"text": "major sigma 43 factor of B. subtilis RNA polymerase", "start": 217, "end": 268}]}}, "schema": []}
{"input": "Selective effect of pulmonary oedema on prostaglandin E2 pharmacokinetics in rat lung.", "output": {"entities": {}}, "schema": []}
{"input": "This article will briefly review the published data on the morphology, function, and biochemistry of the normal renal medulla and the pathology associated with RPN, together with the secondary changes which give rise to cortical degeneration or epithelial carcinoma.", "output": {"entities": {}}, "schema": []}
{"input": "The data indicate that the five different (and partially overlapping) sry messenger RNAs detectable in early embryos are initiated at three separate sites, each directly upstream from one of the three protein-coding regions, designated (in 5' to 3' order) beta, alpha and delta.", "output": {"entities": {"gene": [{"text": "sry messenger RNAs", "start": 70, "end": 88}]}}, "schema": []}
{"input": "Chronic thyroiditis as a risk factor of B-cell lymphoma in the thyroid gland.", "output": {"entities": {}}, "schema": []}
{"input": "Plasma secretin levels also augmented after the administration of ethanol solutions, with a delay of about one hour after the onset of acid secretion.", "output": {"entities": {"gene": [{"text": "Plasma secretin", "start": 0, "end": 15}]}}, "schema": []}
{"input": "Spectrophotometric microanalysis of ethylenediaminotetracetic acid in pharmaceutical preparations", "output": {"entities": {}}, "schema": []}
{"input": "A comparison among the 5' flanking regions encompassing the presumptive HS promoter of the soybean HS-protein genes demonstrated this region to be extremely homologous.", "output": {"entities": {"gene": [{"text": "HS promoter", "start": 72, "end": 83}, {"text": "soybean HS-protein genes", "start": 91, "end": 115}]}}, "schema": []}
{"input": "Using this method, we measured absorption of low doses of vitamin A, which may provide a more physiological approach to assessment of fat malabsorption.", "output": {"entities": {}}, "schema": []}
{"input": "Fulminant hepatitis A in chronic HBV carrier.", "output": {"entities": {}}, "schema": []}
{"input": "During this time, the patients all had the characteristic plasma thyroid hormone changes associated with amiodarone therapy, i. e. increased T4, free T4, and rT3 and decreased T3, while remaining clinically euthyroid.", "output": {"entities": {}}, "schema": []}
{"input": "Drug and nutrient interactions.", "output": {"entities": {}}, "schema": []}
{"input": "In each compartment O2 is removed by the tissues as a chemical reaction takes place between O2 and oxyhemoglobin (HbO2).", "output": {"entities": {"gene": [{"text": "oxyhemoglobin", "start": 99, "end": 112}, {"text": "HbO2", "start": 114, "end": 118}]}}, "schema": []}
{"input": "To evaluate the effects of propranolol on myocardial metabolism after coronary reperfusion, serial measurements of myocardial creatine kinase (CK) and calcium (Ca) contents and CK and lactic acid (LA) concentrations in coronary sinus blood were carried out in 33 open-chest dogs.", "output": {"entities": {"gene": [{"text": "myocardial creatine kinase", "start": 115, "end": 141}, {"text": "CK", "start": 143, "end": 145}, {"text": "CK", "start": 177, "end": 179}]}}, "schema": []}
{"input": "Cortisol excretion, appeared to be markedly affected by the season although other factors such as social and environmental stress cannot be discounted.", "output": {"entities": {}}, "schema": []}
{"input": "Two studies on the relationship between taking a commercial coaching course and performance on the Medical College Admission Test (MCAT) are reported.", "output": {"entities": {}}, "schema": []}
{"input": "A total of 90 patients were randomly allocated either to an MY-1 treated or an untreated group.", "output": {"entities": {}}, "schema": []}
{"input": "Below 50% decrease of PaO2, NADH was reduced largely.", "output": {"entities": {}}, "schema": []}
{"input": "Angiography was performed following the rCBF study and the degree of vasospasm was measured on the angiograms.", "output": {"entities": {}}, "schema": []}
{"input": "The financial impact of childhood asthma has not been assessed since Vance and Taylor reported their data in Annals of Allergy 13 years ago.", "output": {"entities": {}}, "schema": []}
{"input": "Hypersplenism", "output": {"entities": {}}, "schema": []}
{"input": "Electrical activity was evaluated by monitoring the general electrocorticogram (ECoG) as well as local DC steady potential (two sites).", "output": {"entities": {}}, "schema": []}
{"input": "The topography and trajectories of the commissural fibers of the superior temporal region (STR) are studied using the autoradiographic technique.", "output": {"entities": {}}, "schema": []}
{"input": "The diabetic state was characterized by mild insulin deficiency, plasma levels being 73% of controls, and mild hyperglycemia, with nonfasting plasma glucose levels of 1. 5 times normal.", "output": {"entities": {"gene": [{"text": "insulin", "start": 45, "end": 52}]}}, "schema": []}
{"input": "No consistent correlation between blood pressure change and SCR-change was seen.", "output": {"entities": {}}, "schema": []}
{"input": "Shoulder forearm support for the subluxed shoulder.", "output": {"entities": {}}, "schema": []}
{"input": "Piroxicam produced a lower incidence of gastric ulcers than equivalent doses of indomethacin.", "output": {"entities": {}}, "schema": []}
{"input": "These findings suggest that both in the early stages (0T, 0N) and in more severe stages of VWF (stages 1-2) cold induced hyperreactivity in the digital vessels and Raynaud' s syndrome are vascular disorders of functional origin occurring without any prethrombotic alterations.", "output": {"entities": {}}, "schema": []}
{"input": "In MCCP functions of the source emission, surface reflection, photoacceptor sensitivity are approximated by the normal distribution curves.", "output": {"entities": {}}, "schema": []}
{"input": "To assess the effects of alveolar hypoxia and angiotensin II infusion on distribution of blood flow to the lung we performed perfusion lung scans on anesthetized mechanically ventilated lambs.", "output": {"entities": {"gene": [{"text": "angiotensin II", "start": 46, "end": 60}]}}, "schema": []}
{"input": "A flow rate of at least 5 mL/h is required through the receptor (volume, 0. 4 mL) for accurate results.", "output": {"entities": {}}, "schema": []}
{"input": "We have now located the 5' ends of the two remaining late mRNAs.", "output": {"entities": {}}, "schema": []}
{"input": "The efficacy of quantitative and qualitative chloride titrators in the estimation of human salt intake.", "output": {"entities": {}}, "schema": []}
{"input": "Doctor Berglund warns members of union pitfalls.", "output": {"entities": {}}, "schema": []}
{"input": "Acute appearance of hemiparesis or hemiplegia with initial marked spasticity was observed in 8 stroke patients.", "output": {"entities": {}}, "schema": []}
{"input": "Recurrent acute rhinosinusitis was common in both groups of patients, but the development of chronic rhinosinusitis was only found in patients with CVID, indicating the more severe nature of this condition compared with selective IgA deficiency.", "output": {"entities": {"gene": [{"text": "IgA", "start": 230, "end": 233}]}}, "schema": []}
{"input": "These data suggest that AP-A may be potentially useful in the management of heart failure.", "output": {"entities": {"gene": [{"text": "AP-A", "start": 24, "end": 28}]}}, "schema": []}
{"input": "The various muscles of the pelvic floor region could be reflexly activated either individually or as a mass unit depending on the intensity of stimulation.", "output": {"entities": {}}, "schema": []}
{"input": "The frequency of lactase phenotypes in Aymara children.", "output": {"entities": {"gene": [{"text": "lactase phenotypes", "start": 17, "end": 35}]}}, "schema": []}
{"input": "Activities of hepatic cytochrome P-450-dependent metabolizing enzymes such as aminopyrine-and TMO N-demethylase and aniline hydroxylase activity were decreased by pretreatment of rats with cimetidine, whereas in the rats pretreated with ranitidine, these enzyme activities were not changed.", "output": {"entities": {"gene": [{"text": "cytochrome P-450", "start": 22, "end": 38}, {"text": "aminopyrine-and TMO N-demethylase", "start": 78, "end": 111}, {"text": "aniline hydroxylase", "start": 116, "end": 135}]}}, "schema": []}
{"input": "Doxorubicin, dacarbazine, vincristine, and cyclophosphamide in the treatment of advanced gastrointestinal leiomyosarcoma.", "output": {"entities": {}}, "schema": []}
{"input": "The effect of the opiate antagonist naloxone was evaluated in 11 unselected patients with cerebral ischemia.", "output": {"entities": {}}, "schema": []}
{"input": "Electrochemical detection of depressed circulating levels of vitamin K1 in osteoporosis.", "output": {"entities": {}}, "schema": []}
{"input": "In the present experiments, we investigate the role played by the temporal pattern of neural activity during the ontogeny of frequency tuning in the mouse central auditory system.", "output": {"entities": {}}, "schema": []}
{"input": "Ultrastructure of the tumor in 1 patient in whom transurethral resection was performed 2 weeks after alum irrigation revealed well preserved nuclear chromatin, thus, suggesting that whatever changes occur after alum irrigation are short-lived.", "output": {"entities": {}}, "schema": []}
{"input": "The generally adopted criteria enabling to classify the examined persons into the following 3 groups have been used: (a) diseased of BEN; (b) suspect to be diseased of BEN, and (c) individuals without signs of a renal disease.", "output": {"entities": {}}, "schema": []}
{"input": "The POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal component, Skin).", "output": {"entities": {}}, "schema": []}
{"input": "During a disease remission there was an increase in GAG secretion with urine, linked with hyperheparinuria (13. 1-fold, P less than 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "In metastasis-free patients, the best results were obtained with tumor diameters under 2 cm regardless of their localization in lung tissue and with 2--4. 9 cm tumors embedded in lung parenchyma.", "output": {"entities": {}}, "schema": []}
{"input": "Two siblings with hemolytic anemia caused by triosephosphate isomerase deficiency developed a progressive neurological syndrome featuring dystonic movements, tremor, pyramidal tract signs, and evidence of spinal motor neuron involvement.", "output": {"entities": {"gene": [{"text": "triosephosphate isomerase", "start": 45, "end": 70}]}}, "schema": []}
{"input": "One extract with the lowest PCA content was non-carcinogenic.", "output": {"entities": {}}, "schema": []}
{"input": "Aortic diameters in infants and young children: normative angiographic data.", "output": {"entities": {}}, "schema": []}
{"input": "The present investigation has revealed that the distribution of the main fatty acids in Leptospira phospholipids is similar to their distribution in Leptospira neutral lipids with the exception of unsaturated fatty acid with 14 carbon atoms, occurring mainly in phospholipids.", "output": {"entities": {}}, "schema": []}
{"input": "Since 1970 the frequency of potassium-induced ulceration has been low--3 cases per 100 000 patient-years of slow-release tablet use.", "output": {"entities": {}}, "schema": []}
{"input": "Hydrocortisone caused lymphopenia and inhibited the blastogenic response of peripheral blood lymphocytes to phytohemagglutinin and concanavalin A mitogens.", "output": {"entities": {"gene": [{"text": "phytohemagglutinin", "start": 108, "end": 126}, {"text": "concanavalin A", "start": 131, "end": 145}]}}, "schema": []}
{"input": "To test the feasibility of using liposomes to deliver therapeutic agents to the lungs, the effect of liposome-encapsulated superoxide dismutase (SOD) or catalase on pulmonary oxygen toxicity was studied in rats.", "output": {"entities": {"gene": [{"text": "superoxide dismutase", "start": 123, "end": 143}, {"text": "SOD", "start": 145, "end": 148}, {"text": "catalase", "start": 153, "end": 161}]}}, "schema": []}
{"input": "Marrow cell necrosis in anorexia nervosa and involuntary starvation.", "output": {"entities": {}}, "schema": []}
{"input": "For comparison conventional heparin was used during 18 dialyses in the same patients.", "output": {"entities": {}}, "schema": []}
{"input": "Chenodeoxycholic acid (cheno) and ursodeoxycholic acid (urso) dissolve cholesterol gallstones in man.", "output": {"entities": {}}, "schema": []}
{"input": "Sensory evoked field potentials were recorded from the mesencephalic reticular formation (MRF), central gray (CG) and somatosensory cortex (SCX), following incremental doses of halothane in freely-moving rats.", "output": {"entities": {}}, "schema": []}
{"input": "Ultrastructure of the heart muscle in experimental myocardial infarct following physical training", "output": {"entities": {}}, "schema": []}
{"input": "Pharmacological desympathization leads to the development of hyper-reactivity of the true pacemakers to noradrenaline and dopamine and triggers off changes in the regulation of the electric activity of these cells by catecholamines.", "output": {"entities": {}}, "schema": []}
{"input": "OODG is a diagnostic method permitting assessment of ocular pulse curves and objective determination of blood pressures in the ophthalmic circulatory system (retinal and ciliary arterial blood pressures) simultaneously for both eyes, without dilatation of the pupils.", "output": {"entities": {}}, "schema": []}
{"input": "Viral infections have long been suspected to be causative agents in a number of inner ear dysfunctions.", "output": {"entities": {}}, "schema": []}
{"input": "55 +/-11%), all other parameters showed a significant increase: RS index 5. 4 +/-1. 4 mVolt to 6. 0 +/-1. 7 mVolt (p less than 0. 01); EDD 6. 3 +/-0. 7 to 6. 8 +/-0. 9 cm (p less than 0. 001); HV 1017 +/-151 ml to 1099 +/-261 ml (p less than 0. 01); EDV 371 +/-131 ml to 441 +/-175 ml (p less than 0. 001); RBV 117 +/-57 ml to 151 +/-77 ml (p less than 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "Retrospective analyses of this death revealed a significant decrease of the left ventricular (LV) end-diastolic volume index (EDVI) of 21 ml/m2 (36% of normal).", "output": {"entities": {}}, "schema": []}
{"input": "In group I adults both of these variables increased.", "output": {"entities": {}}, "schema": []}
{"input": "Individual alcohol reaction profiles.", "output": {"entities": {}}, "schema": []}
{"input": "Vitiligo in diabetes mellitus.", "output": {"entities": {}}, "schema": []}
{"input": "The pharmacokinetics of each tetracycline in serum and dermal, suction blister fluid were determined after oral doses of 300 mg lymecycline or 100 mg doxycycline on the 3rd day.", "output": {"entities": {}}, "schema": []}
{"input": "A high degree of correlation in the sense of the classic conception of brain localization of neuropsychological syndromes was found.", "output": {"entities": {}}, "schema": []}
{"input": "35 patients with acute arterial occlusions [27] and graft thromboses [8], responsible for severe and recent ischemia, were treated by fibrinolytic therapy (Urokinase: 1 000 units/kg/hour, and Lys Plasminogen).", "output": {"entities": {"gene": [{"text": "Urokinase", "start": 156, "end": 165}, {"text": "Plasminogen", "start": 196, "end": 207}]}}, "schema": []}
{"input": "We conclude that androgenic hormones reduce HDL-cholesterol concentrations and the HDL2-cholesterol subfraction, possibly by enhancing hepatic triglyceride lipase activity.", "output": {"entities": {"gene": [{"text": "HDL-cholesterol", "start": 44, "end": 59}, {"text": "HDL2-cholesterol", "start": 83, "end": 99}, {"text": "hepatic triglyceride lipase", "start": 135, "end": 162}]}}, "schema": []}
{"input": "Because of its wide spectrum of activity particularly against ampicillin resistant strains of H. influenzae and because of its good tolerance Cefaclor is very useful in treatment of respiratory tract infections in children.", "output": {"entities": {}}, "schema": []}
{"input": "Shape factor correlated well with hemodynamic data for RV/LV systolic pressure ratios (r = 0. 93, p less than 0. 001) for normalized interventricular pressure differences (r =-0. 95, p less than 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "The effective and low toxic dose schedules of KW-2083 should be investigated further.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, the initial plasma retinol level in conjunction with RBP was found to be even lower in 12 patients (35. 1 micrograms dl-1, 3. 7 mg dl-1) who subsequently had cancer recurrence than in those who remained free of apparent cancer (44. 5 micrograms dl-1, 4. 6 mg dl-1).", "output": {"entities": {"gene": [{"text": "RBP", "start": 66, "end": 69}]}}, "schema": []}
{"input": "The results indicate that: 1) the initial response to tethering varies according to previous penning and handling experience, 2) although the circadian rhythm of cortisol was either altered or disrupted during estrus, such disruptions were not influenced by type of penning and 3) tether stalls may chronically increase cortisol concentrations in gilts.", "output": {"entities": {}}, "schema": []}
{"input": "This laser provided sufficient power in an amniotic fluid medium to occlude placental vessels as large as 7 mm in diameter within 6 seconds at a power density of 2000 W/cm2.", "output": {"entities": {}}, "schema": []}
{"input": "On d 112, progesterone was higher (P less than. 05) in hysterectomized heifers than in other treatment groups.", "output": {"entities": {}}, "schema": []}
{"input": "Male Japanese quail were chronically exposed to 5000 ppm manganese (Mn) as particulate manganese oxide (Mn3O4) in their diet from hatching to 75 days of age.", "output": {"entities": {}}, "schema": []}
{"input": "This study indicated that the Japanese quail was less sensitive to particulate Mn3O4 exposure than rodents treated comparably.", "output": {"entities": {}}, "schema": []}
{"input": "Plasma and bladder platinum concentration were measured following intravesical DDP, and also histopathological examination, urinalysis, complete blood count and blood chemistry were performed in order to know the toxicity of intravesical DDP.", "output": {"entities": {}}, "schema": []}
{"input": "Scintigraphic visualisation of Walker carcinoma-256 in Sprague-Dawley rats by means of 99mTc-labelled monocytes.", "output": {"entities": {}}, "schema": []}
{"input": "Rabbit eyes were removed and held in temperature-regulated chambers and irrigated with saline.", "output": {"entities": {}}, "schema": []}
{"input": "Before birth, there were a few perivascular adrenergic nerves and correspondingly low ovarian NE levels.", "output": {"entities": {}}, "schema": []}
{"input": "Monitoring changes in the heart rate of the premature fetus during tocolysis with the beta-adrenomimetics partusisten and Pre-par", "output": {"entities": {}}, "schema": []}
{"input": "Since September 1980 to June 1983 we have treated 32 patients with ovarian cancer.", "output": {"entities": {}}, "schema": []}
{"input": "The results suggest that the calcium antagonist, diltiazem, may modify the effects of isoflurane on myocardial function.", "output": {"entities": {}}, "schema": []}
{"input": "Supraventricular arrhythmias--digoxin and quinidine revisited.", "output": {"entities": {}}, "schema": []}
{"input": "Visidex I is unsuitable for storage and re-reading.", "output": {"entities": {}}, "schema": []}
{"input": "The Cox proportional hazards model was applied to the data in order to determine the prognostic factors for long-term survival.", "output": {"entities": {}}, "schema": []}
{"input": "This suggests that mechanisms other than an excessive increase in myocardial oxygen demand may be responsible for the many episodes occurring outside the hospital.", "output": {"entities": {}}, "schema": []}
{"input": "These data showed: that progesterone secretion is pulsatile throughout the human luteal phase, with maximum frequency in the mid-luteal phase; that during the mid-luteal phase most subjects had progesterone levels both above and below currently accepted ovulatory thresholds; the use of a single measurement of progesterone in the mid-luteal phase is not always a reliable indicator of ovulation; a threshold greater than 20 nmol/l may yield an unacceptable number of false negative results.", "output": {"entities": {}}, "schema": []}
{"input": "This slope tended to be higher (approximately 1. 6 dB/dB) for L1 = L2 greater than 80 dB.", "output": {"entities": {}}, "schema": []}
{"input": "Histamine reactivity was significantly reduced after the nifedipine aerosol, the geometric mean provocative concentration causing a 35% fall in specific airway conductance, rising from 5. 0 to 10. 9 mg/ml of histamine (p less than 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "Pharmacologic doses of vitamin B6 administered to lactating women have been reported to suppress plasma prolactin.", "output": {"entities": {"gene": [{"text": "plasma prolactin", "start": 97, "end": 113}]}}, "schema": []}
{"input": "There was a significant but similar elevation of mean O2 uptake during 40 min postexercise by 13. 6% in both the fasted (p less than 0. 001) and fed state (p less than 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "In controls, most of the output from the conduit occurred during type I activity (73 +/-14%).", "output": {"entities": {}}, "schema": []}
{"input": "Greater attenuation of the N1-P2 and baseline-P2 amplitude of the probe EPs was observed when the probe stimulus was presented to the right ear and the verbal material presented to the left ear than when the opposite stimulation arrangement was used.", "output": {"entities": {}}, "schema": []}
{"input": "Twenty-five patients (80, 6%) with mixed neoplasms were operated on by total conservative parotidectomy (T. C. P.), 3 (9, 7%) by S. P. and 3 (9, 7%) by En.", "output": {"entities": {}}, "schema": []}
{"input": "The comparisons revealed that female homicide-suicide perpetrators were more likely than female homicide-suicide victims to live in mobile homes, kill their lover or ex-lover, have their crime accidentally discovered, leave a suicide note, kill on a weekend, and be depressed, but are less likely than female homicide-suicide victims to live with a spouse.", "output": {"entities": {}}, "schema": []}
{"input": "Germ-free rabbits given mouse CRF-flora showed values quite different from control animals for most parameters, indicating unsuitability of mouse CRF flora to' normalize' rabbits.", "output": {"entities": {}}, "schema": []}
{"input": "The weak relationships between F and Zn to Mg clearly have no significant effect on the contents of these elements in bone.", "output": {"entities": {}}, "schema": []}
{"input": "L3-L4 compressive load was calculated using a model of the anatomy of the trunk musculoskeletal system.", "output": {"entities": {}}, "schema": []}
{"input": "Component P100 was associated with a frontal negativity of similar latency favoring the hypothesis of a dipolar occipital generator.", "output": {"entities": {}}, "schema": []}
{"input": "Although no differences were noted in the decrease in platelet counts between the two groups, fibrinogen levels and alpha 2-antiplasmin levels declined less drastically in the antithrombin-treated group.", "output": {"entities": {"gene": [{"text": "fibrinogen", "start": 94, "end": 104}, {"text": "alpha 2-antiplasmin", "start": 116, "end": 135}, {"text": "antithrombin", "start": 176, "end": 188}]}}, "schema": []}
{"input": "Failure of stapedius reflexometry in the diagnosis of myasthenia gravis.", "output": {"entities": {}}, "schema": []}
{"input": "Factors influencing semen characteristics in young boars reared in a subtropical environment were studied.", "output": {"entities": {}}, "schema": []}
{"input": "[14C]-beta-phenethylamine, its distribution after administration by various routes to cats, and the effects of monoamine oxidase inhibitors.", "output": {"entities": {"gene": [{"text": "monoamine oxidase", "start": 111, "end": 128}]}}, "schema": []}
{"input": "All runners drank a total of 1. 4 L of water during the race.", "output": {"entities": {}}, "schema": []}
{"input": "The rates of total energy use (mean +/-SD = 39. 3 +/-1. 2 vs 35. 7 +/-1. 3 kJ X min-1; P less than 0. 05) were significantly higher at-10 degrees C than at 22 degrees C.", "output": {"entities": {}}, "schema": []}
{"input": "Clinical aspects and therapy", "output": {"entities": {}}, "schema": []}
{"input": "Following seven days' incubation both at 20 degrees C and 28 degrees C, Ae. vexans nip. was capable of transmitting the virus.", "output": {"entities": {}}, "schema": []}
{"input": "Blood eosinophils in patients with Taenia saginata taeniasis.", "output": {"entities": {}}, "schema": []}
{"input": "The recommendation is made that specific sub-groups of attempters need to be identified and may warrant specialized intervention strategies.", "output": {"entities": {}}, "schema": []}
{"input": "There was no correlation between secretor status and clinical status, spirometry measurements, salivary and serum lysozyme levels or rates of respiratory tract colonization with P. aeruginosa and S. aureus.", "output": {"entities": {"gene": [{"text": "salivary and serum lysozyme", "start": 95, "end": 122}]}}, "schema": []}
{"input": "There was no correlation between secretor status and clinical status, spirometry measurements, salivary and serum lysozyme levels or rates of respiratory tract colonization with P. aeruginosa and S. aureus.", "output": {"entities": {"gene": [{"text": "serum lysozyme", "start": 108, "end": 122}]}}, "schema": []}
{"input": "Gains increased 3. 5% (P less than. 10) and feed conversion improved 5. 9% (P less than. 07) in steers fed. 28% AS-VFA compared with gain and feed conversion of the control steers.", "output": {"entities": {}}, "schema": []}
{"input": "Daily and seasonal rhythmicity in the methylation of pineal indolic compounds in adult male golden hamsters, kept under natural conditions.", "output": {"entities": {}}, "schema": []}
{"input": "The transit time was significantly shortened.", "output": {"entities": {}}, "schema": []}
{"input": "Among the patients grades 1-2-3, 81% had a good out come without any neurological abnormality, among the patients graded 4-5, only 27% had a fair out come.", "output": {"entities": {}}, "schema": []}
{"input": "Activity of acid hydrolases of peripheral blood leukocytes in focal and segmental pneumonia in children", "output": {"entities": {"gene": [{"text": "acid hydrolases", "start": 12, "end": 27}]}}, "schema": []}
{"input": "Comparative studies of the antithrombin III level and plasminogen activator activity in patients with thrombophlebitis", "output": {"entities": {"gene": [{"text": "antithrombin III", "start": 27, "end": 43}, {"text": "plasminogen activator", "start": 54, "end": 75}]}}, "schema": []}
{"input": "Relations between cellular electrical activity and cardiac mechanical activity in man, the dog and the rabbit", "output": {"entities": {}}, "schema": []}
{"input": "Treatment of Paget' s disease.", "output": {"entities": {}}, "schema": []}
{"input": "Improvement of the CRT display of an averager.", "output": {"entities": {}}, "schema": []}
{"input": "Is desensitization' for ragweed hay fever immunologically specific?", "output": {"entities": {}}, "schema": []}
{"input": "Renal excretion of sulphadimidine in normal and uraemic subjects.", "output": {"entities": {}}, "schema": []}
{"input": "Experiences with the clinical and experimental use of Urat-I lithotriptor.", "output": {"entities": {}}, "schema": []}
{"input": "Formation of hyphae and chlamydospores by Cryptococcus laurentii.", "output": {"entities": {}}, "schema": []}
{"input": "Evaluation of thyroid function.", "output": {"entities": {}}, "schema": []}
{"input": "The effect of a tissue emulsion, vitamin A and nonspecific gamma-globulin on the blood clearance in rabbits", "output": {"entities": {"gene": [{"text": "gamma-globulin", "start": 59, "end": 73}]}}, "schema": []}
{"input": "HL-A antibodies in polytransfused patients", "output": {"entities": {"gene": [{"text": "HL-A antibodies", "start": 0, "end": 15}]}}, "schema": []}
{"input": "Demonstration of fine structure of the guinea pig organ of Corti after electron microscopic silver staining", "output": {"entities": {}}, "schema": []}
{"input": "Histamine metabolism in hemorrhagic-hypotensive shock", "output": {"entities": {}}, "schema": []}
{"input": "Relaxation of catch in a molluscan smooth muscle.", "output": {"entities": {}}, "schema": []}
{"input": "Studies on alcoholic liver injury.", "output": {"entities": {}}, "schema": []}
{"input": "Hypothalamic control of coronary circulation in the dog.", "output": {"entities": {}}, "schema": []}
{"input": "Evidence for two distinctive clinical, epidemiological, and immunological types of infection.", "output": {"entities": {}}, "schema": []}
{"input": "Ultraviolet light-induced kinin formation in human skin.", "output": {"entities": {"gene": [{"text": "kinin", "start": 26, "end": 31}]}}, "schema": []}
{"input": "Poliomyelitis from a vaccine.", "output": {"entities": {}}, "schema": []}
{"input": "To the problem of the stimulation of the growth of transplantable tumors of animals previously treated with antineoplastic antibiotics", "output": {"entities": {}}, "schema": []}
{"input": "Assessment of nutrient media in the diagnosis of diptheria", "output": {"entities": {}}, "schema": []}
{"input": "Aluminium resin for the treatment of the hyperkalamia of renal failure.", "output": {"entities": {}}, "schema": []}
{"input": "Value of the EMG in the diagnosis of a cardiomyopathy associated with a myotonic myopathy.", "output": {"entities": {}}, "schema": []}
{"input": "D.", "output": {"entities": {}}, "schema": []}
{"input": "Prevention of maternal Rh sensitization: anti-Rh immune globulin.", "output": {"entities": {"gene": [{"text": "anti-Rh immune globulin", "start": 41, "end": 64}]}}, "schema": []}
{"input": "Serotonin levels in infant hypothyroidism.", "output": {"entities": {}}, "schema": []}
{"input": "Cerebrospinal fluid transferrin II studies in ischemic disorders of the central nervous system.", "output": {"entities": {"gene": [{"text": "transferrin II", "start": 20, "end": 34}]}}, "schema": []}
{"input": "High dosages of D-penicillamine in pulmonary fibroses", "output": {"entities": {}}, "schema": []}
{"input": "Inverse relation between serum IgG concentration and glucose and xylose absorption in Zambian African adults.", "output": {"entities": {"gene": [{"text": "IgG", "start": 31, "end": 34}]}}, "schema": []}
{"input": "Disorders of platelet function in chronic myeloid leukemias", "output": {"entities": {}}, "schema": []}
{"input": "The effect of anticonvulsants on sodium-potassium-activated ATPase, sodium, and potassim in cortex.", "output": {"entities": {"gene": [{"text": "sodium-potassium-activated ATPase", "start": 33, "end": 66}]}}, "schema": []}
{"input": "Effect of immune lymphocytes and of rabbit-anti-lymphocyte globulin (RAMLG) on infected macrophages exposed to increased incubation temperature in vitro.", "output": {"entities": {"gene": [{"text": "rabbit-anti-lymphocyte globulin", "start": 36, "end": 67}, {"text": "RAMLG", "start": 69, "end": 74}]}}, "schema": []}
{"input": "Lactation of baboons fed a low protein maintenance diet.", "output": {"entities": {}}, "schema": []}
{"input": "A medical-geographical review", "output": {"entities": {}}, "schema": []}
{"input": "Age and sex structure of the natural population of Ornithodoros tatarovski Ol.", "output": {"entities": {}}, "schema": []}
{"input": "Vitamin D3 and calcium absorption in the chick.", "output": {"entities": {}}, "schema": []}
{"input": "The incidence of tumours in young chickens.", "output": {"entities": {}}, "schema": []}
{"input": "Laboratory aspects with particular reference to chemotherapy and control.", "output": {"entities": {}}, "schema": []}
{"input": "Their effect on the guinea pig vas deferens.", "output": {"entities": {}}, "schema": []}
{"input": "Androgens and growth.", "output": {"entities": {}}, "schema": []}
{"input": "Therapeutic action of a new antibiotic-corticoid association used for instillations in otology", "output": {"entities": {}}, "schema": []}
{"input": "Clinico-physiological experiment", "output": {"entities": {}}, "schema": []}
{"input": "Enzyme histochemical findings in the ultimobranchial body of the horse", "output": {"entities": {}}, "schema": []}
{"input": "Familial glutathione reductase deficiency and disorder of glutathione synthesis in the erythrocyte", "output": {"entities": {"gene": [{"text": "glutathione reductase", "start": 9, "end": 30}]}}, "schema": []}
{"input": "Studies on swine enteroviruses.", "output": {"entities": {}}, "schema": []}
{"input": "Serodiagnosis of ectromelia in laboratory mice", "output": {"entities": {}}, "schema": []}
{"input": "Ultrasound effect on the cytochrome oxidase activity", "output": {"entities": {"gene": [{"text": "cytochrome oxidase", "start": 25, "end": 43}]}}, "schema": []}
{"input": "Genesis of foam cells: study in rats after administration of Cloforex.", "output": {"entities": {}}, "schema": []}
{"input": "Conditions influencing inhibitors of the colony-stimulating factor (CSF).", "output": {"entities": {"gene": [{"text": "colony-stimulating factor", "start": 41, "end": 66}, {"text": "CSF", "start": 68, "end": 71}]}}, "schema": []}
{"input": "Absence of action potentials in frog slow muscle fibres paralysed by botulinum toxin.", "output": {"entities": {"gene": [{"text": "botulinum toxin", "start": 69, "end": 84}]}}, "schema": []}
{"input": "An automated method for the quantitative analysis of the polyamines putrescine, spermidine and spermine in cerebrospinal fluid (CSF) was used to analyze CSF samples from 37 patients with central nervous system (CNS) tumors and from 13 patients without tumors.", "output": {"entities": {}}, "schema": []}
{"input": "Disulfiram and the drug-induced effects on motility.", "output": {"entities": {}}, "schema": []}
{"input": "Particles resembling microbodies in normal and neoplastic perianal glands of dogs.", "output": {"entities": {}}, "schema": []}
{"input": "Natural and induced malarias in western hemisphere monkeys.", "output": {"entities": {}}, "schema": []}
{"input": "Intracranial arachnoid cyst of the middle fossa demonstrated by positive 99mTc brainscintigraphy.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of estrogen and glucocorticoids on the adrenal development of the fetus.", "output": {"entities": {}}, "schema": []}
{"input": "Copper and ceruloplasmin content in pregnant women and in women with certain gynecological diseases", "output": {"entities": {"gene": [{"text": "ceruloplasmin", "start": 11, "end": 24}]}}, "schema": []}
{"input": "Effect of noise on CO-induced increases of LAP and GPT activity in the plasma of rats", "output": {"entities": {"gene": [{"text": "LAP", "start": 43, "end": 46}, {"text": "GPT", "start": 51, "end": 54}]}}, "schema": []}
{"input": "Kinetics of calcium metabolism.", "output": {"entities": {}}, "schema": []}
{"input": "On the transport of mucus and its rheologic simulants in ciliated systems.", "output": {"entities": {}}, "schema": []}
{"input": "A hydrodynamic description of the osmotic reflection coefficient with application to the pore theory of transcapillary exchange.", "output": {"entities": {}}, "schema": []}
{"input": "Pathology of neuritis caudae equinae in the horse", "output": {"entities": {}}, "schema": []}
{"input": "Abnormal characteristics and verticillation in Platynothrus peltifer", "output": {"entities": {}}, "schema": []}
{"input": "Selected topics in laboratory animal medicine.", "output": {"entities": {}}, "schema": []}
{"input": "On parents", "output": {"entities": {}}, "schema": []}
{"input": "From the Icelandic Red Cross activities", "output": {"entities": {}}, "schema": []}
{"input": "Effects of alcoholism on the family", "output": {"entities": {}}, "schema": []}
{"input": "Treatment and care of adult diabetes mellitus without coma", "output": {"entities": {}}, "schema": []}
{"input": "Junctions between cells of the human enamel organ.", "output": {"entities": {}}, "schema": []}
{"input": "Electrocardiograms of the month.", "output": {"entities": {}}, "schema": []}
{"input": "Composites as restoration materials", "output": {"entities": {}}, "schema": []}
{"input": "Hodgkin' s disease.", "output": {"entities": {}}, "schema": []}
{"input": "Value of Normotest and antithrombin 3 in the assessment of liver function.", "output": {"entities": {"gene": [{"text": "antithrombin 3", "start": 23, "end": 37}]}}, "schema": []}
{"input": "Glutathione peroxidase in human red cells in health and disease.", "output": {"entities": {"gene": [{"text": "Glutathione peroxidase", "start": 0, "end": 22}]}}, "schema": []}
{"input": "Histopathologic response of gingival tissues to hemodent and aluminum chloride solutions as tissue displacement materials.", "output": {"entities": {}}, "schema": []}
{"input": "Changes following periodontal surgery.", "output": {"entities": {}}, "schema": []}
{"input": "Intracellular pH, H ion flux and H ion permeability coefficient in bullfrog toe muscle.", "output": {"entities": {}}, "schema": []}
{"input": "Directives concerning medical care", "output": {"entities": {}}, "schema": []}
{"input": "Proceedings: Reversible complete heart block following surgery of congenital heart defects", "output": {"entities": {}}, "schema": []}
{"input": "Method of synthesis of the rheumatoid factor in clinico-immunological studies", "output": {"entities": {"gene": [{"text": "rheumatoid factor", "start": 27, "end": 44}]}}, "schema": []}
{"input": "Variations of the timing of deflections in the His bundle recordings.", "output": {"entities": {}}, "schema": []}
{"input": "Extracellular fibril formation by neuroglial cells at the vitreoretinal junction of the human eye.", "output": {"entities": {}}, "schema": []}
{"input": "Blood platelets, coagulation factors and morphologic organ changes following scalding shock in rhesus monkeys", "output": {"entities": {}}, "schema": []}
{"input": "Cell viability and lysosomal enzymes", "output": {"entities": {}}, "schema": []}
{"input": "State-approved schools of nursing--R. N., 1972.", "output": {"entities": {}}, "schema": []}
{"input": "Further investigation on the chemotactic influence of thymic hormone on lymphocytes", "output": {"entities": {"gene": [{"text": "thymic hormone", "start": 54, "end": 68}]}}, "schema": []}
{"input": "1, 3-bis (2-chloroethyl)-1-nitrosourea (bcnu) and other nitrosoureas in cancer treatment: a review.", "output": {"entities": {}}, "schema": []}
{"input": "Pneumothorax following lung abscess in the renal transplant patient.", "output": {"entities": {}}, "schema": []}
{"input": "Taxonomically significant colour changes in Brevibacterium linens probably associated with a carotenoid-like pigment.", "output": {"entities": {}}, "schema": []}
{"input": "Temporal relationships and the development phase affected.", "output": {"entities": {}}, "schema": []}
{"input": "A short history of dermatology in Lagos, Nigeria.", "output": {"entities": {}}, "schema": []}
{"input": "Local graft irradiation as an adjunct to pharmacologic immunosuppression.", "output": {"entities": {}}, "schema": []}
{"input": "Letter: Salmonella detection", "output": {"entities": {}}, "schema": []}
{"input": "Role of biocenosis in the manifestation of Shigella virulence", "output": {"entities": {}}, "schema": []}
{"input": "The effect of antilymphocyte sera on formation of transplantation and anti-infection immunity in mice", "output": {"entities": {}}, "schema": []}
{"input": "Cortical afferents to the entorhinal cortex of the Rhesus monkey.", "output": {"entities": {}}, "schema": []}
{"input": "Mechanism of immunogenesis in vaccination with streptomycin-dependent mutants of salmonellae and shigellae.", "output": {"entities": {}}, "schema": []}
{"input": "Resistance pattern of Mycobacterium tuberculosis (H 37 Rv) to a new antibiotic, lividomycin", "output": {"entities": {}}, "schema": []}
{"input": "Pulmonary arterial pressure and structure in the patas monkey after prolonged administration of aminorex fumarate.", "output": {"entities": {}}, "schema": []}
{"input": "Effect of triftazin and aminazin on hippocampal bioelectric activity", "output": {"entities": {}}, "schema": []}
{"input": "Sex ratio at birth.", "output": {"entities": {}}, "schema": []}
{"input": "Pathological processes in the cervix uteri", "output": {"entities": {}}, "schema": []}
{"input": "General formulae for estimating heritability in a population with related parents.", "output": {"entities": {}}, "schema": []}
{"input": "Measurement of open-loop responses to electrical stimulation in olfactory bulb of cat.", "output": {"entities": {}}, "schema": []}
{"input": "Glucose disappearance rate and changes in plasma nutrients after intravenouly injected glucose in normoglycaemic and hypoglycaemic underweight newborns.", "output": {"entities": {}}, "schema": []}
{"input": "Normal values for the peripheral blood and bone marrow of the grey (Armenian) hamster", "output": {"entities": {}}, "schema": []}
{"input": "The relationship of human umbilical arterial and venous plasma levels of corticosteroids to gestational age.", "output": {"entities": {}}, "schema": []}
{"input": "Antibiotic effect of the mud from heviz", "output": {"entities": {}}, "schema": []}
{"input": "Sulfuric acid concentration in the catalyzed breathalyzer ampules.", "output": {"entities": {}}, "schema": []}
{"input": "Role of histoclinical studies in the prophylaxis of spontaneous abortions", "output": {"entities": {}}, "schema": []}
{"input": "Range behavior of Hereford, Hereford x Holstein and Holstein non-lactating heifers.", "output": {"entities": {}}, "schema": []}
{"input": "Chemical constituents of the gentianaceae V: tetraoxygenated xanthones of Swertia chirata Buch.-Ham.", "output": {"entities": {}}, "schema": []}
{"input": "Microdetermination of adrenocortical steroids by double isotope method.", "output": {"entities": {}}, "schema": []}
{"input": "Compensative justice and moral investment among Japanese, Chinese, and Koreans.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of cortisone, starvation, and rickets on oxidative enzyme activities of epiphyseal cartilage from rats.", "output": {"entities": {}}, "schema": []}
{"input": "Metal coordination compounds of thiabendazole.", "output": {"entities": {}}, "schema": []}
{"input": "Estimation of renin secretion rate and renal plasma flow from peripheral and renal vein renin levels.", "output": {"entities": {"gene": [{"text": "renin", "start": 14, "end": 19}, {"text": "renal vein renin", "start": 77, "end": 93}]}}, "schema": []}
{"input": "Choice of vessel.", "output": {"entities": {}}, "schema": []}
{"input": "Suppression of food intake in the rat by tung oil.", "output": {"entities": {}}, "schema": []}
{"input": "Studies of lipoprotein-X (LP-X) and bile acids in familial LCAT deficiency.", "output": {"entities": {"gene": [{"text": "lipoprotein-X", "start": 11, "end": 24}, {"text": "LP-X", "start": 26, "end": 30}, {"text": "LCAT", "start": 59, "end": 63}]}}, "schema": []}
{"input": "Pneumothorax complicated by chronic steroid treatment.", "output": {"entities": {}}, "schema": []}
{"input": "Manifest anxiety of Vietnam returnees and undergraduates.", "output": {"entities": {}}, "schema": []}
{"input": "Familial juvenile nephronophthisis", "output": {"entities": {}}, "schema": []}
{"input": "Early heparin therapy in 60 children with acute meningococcemia.", "output": {"entities": {}}, "schema": []}
{"input": "9, 11-Seco steroids derived from estradiol 3-methyl ether.", "output": {"entities": {}}, "schema": []}
{"input": "Psychological examinations in patients with chronic kidney insufficiency", "output": {"entities": {}}, "schema": []}
{"input": "Possibilities of needleless administration of various substances to animals", "output": {"entities": {}}, "schema": []}
{"input": "Change in the makeup of the blood following a short-term local action of a permanent magnetic field on the human body", "output": {"entities": {}}, "schema": []}
{"input": "Observations on the flight activities of Chrysops caecutiens L.", "output": {"entities": {}}, "schema": []}
{"input": "Combination of 3 multiple primary malignant and benign tumors of the breasts and uterus", "output": {"entities": {}}, "schema": []}
{"input": "Proceedings: Barrels and somatotopy in S I neocortex of the brush-tailed possum.", "output": {"entities": {}}, "schema": []}
{"input": "Antivitamin K agents", "output": {"entities": {}}, "schema": []}
{"input": "Canine reproduction: effects of a single injection of medroxyprogesterone acetate on the reproductive organs of the bitch.", "output": {"entities": {}}, "schema": []}
{"input": "3.", "output": {"entities": {}}, "schema": []}
{"input": "Hypoglycemic and antidiabetic properties", "output": {"entities": {}}, "schema": []}
{"input": "Hematopoietic system in streptococcal allergy.", "output": {"entities": {}}, "schema": []}
{"input": "Letter: Aryl hydrocarbon hydroxylase and smoking.", "output": {"entities": {"gene": [{"text": "Aryl hydrocarbon hydroxylase", "start": 8, "end": 36}]}}, "schema": []}
{"input": "Evaluation of 1, 10-phenanthroline as a reagent for sialic acid determinations.", "output": {"entities": {}}, "schema": []}
{"input": "Delta-aminolevulinic acid in physiological conditions and some diseases in children", "output": {"entities": {}}, "schema": []}
{"input": "Nonteratogenicity in rats of blighted potatoes and compounds contained in them.", "output": {"entities": {}}, "schema": []}
{"input": "Isolation of tha avian reticuloendothelial virus (strain T).", "output": {"entities": {}}, "schema": []}
{"input": "Observations on saccules of rats exposed to long-term hypergravity.", "output": {"entities": {}}, "schema": []}
{"input": "The levels of galactosyltransferase activity in sera from normal children and patients with cystic fibrosis.", "output": {"entities": {"gene": [{"text": "galactosyltransferase", "start": 14, "end": 35}]}}, "schema": []}
{"input": "Lack of effect of the appetite stimulant pizotifen (BC 105) on the absorption of isonicotinylhydrazine.", "output": {"entities": {}}, "schema": []}
{"input": "Relationship between gross lesions and Escherichia coli serotypes in chronic respiratory disease (CRD) of poultry.", "output": {"entities": {}}, "schema": []}
{"input": "Immunelectrophoretic pattern of Wassermann reagin and comparison of the appearance time between RPCF and FTA antibodies", "output": {"entities": {"gene": [{"text": "RPCF", "start": 96, "end": 100}]}}, "schema": []}
{"input": "Motile nocardoid Actinomycetales.", "output": {"entities": {}}, "schema": []}
{"input": "Electrocardiographic QRS complexes and vectorcardiographic QRS loop", "output": {"entities": {}}, "schema": []}
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{"input": "Yusuf Dawood Docrat L. R. C. P.", "output": {"entities": {}}, "schema": []}
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{"input": "Symposium on presenile spongy encephalopathies.", "output": {"entities": {}}, "schema": []}
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{"input": "Stimulation with MCh produced a Ca-dependent transient elevation of cGMP level from 10 to 80 fmol/gland, peaking at 1-2 min but returning to the basal level by 5 min.", "output": {"entities": {}}, "schema": []}
{"input": "Two hundred forty-three patients have received WR-2721 in Phase I-II studies.", "output": {"entities": {}}, "schema": []}
{"input": "The PEPCK promoter fragment was introduced either in the proper orientation for transcription of the TK gene or in the opposite orientation.", "output": {"entities": {"gene": [{"text": "PEPCK", "start": 4, "end": 9}, {"text": "TK gene", "start": 101, "end": 108}]}}, "schema": []}
{"input": "Many mammary tumors induced by mouse mammary tumor virus (MMTV) contain a provirus in the same region of the host-cell genome, leading to expression of a putative cellular oncogene called int-1.", "output": {"entities": {"gene": [{"text": "int-1", "start": 188, "end": 193}]}}, "schema": []}
{"input": "In these cases, asbestos or erionite-tissue burden followed by fibrosis was frequently observed.", "output": {"entities": {}}, "schema": []}
{"input": "Hepatitis B virus and hepatoma.", "output": {"entities": {}}, "schema": []}
{"input": "USA 80, 3618-3622) The two proteins show 36% identities in their amino acid sequence, in an alignment requiring six gaps.", "output": {"entities": {}}, "schema": []}
{"input": "The envelope glycoproteins of Rous sarcoma virus (RSV), gp85 and gp37, are anchored in the membrane by a 27-amino acid, hydrophobic domain that lies adjacent to a 22-amino acid, cytoplasmic domain at the carboxy terminus of gp37.", "output": {"entities": {"gene": [{"text": "envelope glycoproteins of Rous sarcoma virus (RSV)", "start": 4, "end": 54}, {"text": "gp85", "start": 56, "end": 60}, {"text": "gp37", "start": 65, "end": 69}, {"text": "gp37", "start": 224, "end": 228}]}}, "schema": []}
{"input": "The drug was given in a daily oral dose of 0. 5 g/m2, 3. 5 h prior to each radiation treatment.", "output": {"entities": {}}, "schema": []}
{"input": "Histogenetic aspects of mesoblastic nephroma.", "output": {"entities": {}}, "schema": []}
{"input": "Effect of acute and chronic psychogenic stress on corticoadrenal and pituitary-thyroid hormones in male rats.", "output": {"entities": {"gene": [{"text": "pituitary-thyroid hormones", "start": 69, "end": 95}]}}, "schema": []}
{"input": "An intact 5. 7-kb provirus of the avian erythroblastosis virus E26 has been molecularly cloned for comparisons with avian myeloblastosis virus (AMV) and other avian tumor viruses.", "output": {"entities": {}}, "schema": []}
{"input": "It is concluded that haloperidol selectively reduced the animal' s capacity to' programme non-stimulus directed motor behaviour'.", "output": {"entities": {}}, "schema": []}
{"input": "Neither side effect nor abnormal laboratory findings due to this drug were observed.", "output": {"entities": {}}, "schema": []}
{"input": "The results presented in this report suggest that the SV40 G-C-rich sequences can function as independent RNA polymerase II transcriptional-control elements.", "output": {"entities": {"gene": [{"text": "RNA polymerase II", "start": 106, "end": 123}]}}, "schema": []}
{"input": "Construction of human cell lines which contain and express the adenovirus DNA binding protein gene by cotransformation with the HSV-1 tk gene.", "output": {"entities": {"gene": [{"text": "HSV-1 tk gene", "start": 128, "end": 141}]}}, "schema": []}
{"input": "Diagnosis and treatment of insulin-secreting tumours.", "output": {"entities": {"gene": [{"text": "insulin", "start": 27, "end": 34}]}}, "schema": []}
{"input": "Theories proffered to account for the modality shift effect are critically evaluated.", "output": {"entities": {}}, "schema": []}
{"input": "The effects of cardioselective beta-1 adrenergic agonist, 1-(4-hydroxyphenoxy)-isopropylamino-2-propanol), i. e., prenalterol, were examined on direct and continuous measurements of left ventricular (LV) pressure, diameter, dP/dt, velocity of shortening, arterial pressure, iliac blood flow and heart rate in 10 conscious dogs.", "output": {"entities": {}}, "schema": []}
{"input": "Endorphins at the approach of death.", "output": {"entities": {"gene": [{"text": "Endorphins", "start": 0, "end": 10}]}}, "schema": []}
{"input": "Trial treatment of schizophrenia with des-Tyr-gamma-endorphin", "output": {"entities": {}}, "schema": []}
{"input": "Cardiac taurine levels and sarcolemmal calcium binding activity in furazolidone-induced cardiomyopathy.", "output": {"entities": {}}, "schema": []}
{"input": "Separation of malaria-infected erythrocytes from whole blood: use of a selective high-gradient magnetic separation technique.", "output": {"entities": {}}, "schema": []}
{"input": "The roll-over test to predict toxemia in pregnancy.", "output": {"entities": {}}, "schema": []}
{"input": "Can thyroglobulin assay really supplant radioiodine scans in patients with differentiated thyroid cancer?", "output": {"entities": {"gene": [{"text": "thyroglobulin", "start": 4, "end": 17}]}}, "schema": []}
{"input": "3 Significant reductions in lying mean arterial blood pressure were observed with daily doses of 200 mg (-9%), 400 mg (-10%) and 800 mg (-14%), and were associated with significant decreases in heart rate and plasma renin activity.", "output": {"entities": {"gene": [{"text": "plasma renin", "start": 209, "end": 221}]}}, "schema": []}
{"input": "Isolation of Aeromonas from faeces.", "output": {"entities": {}}, "schema": []}
{"input": "(iii) The mRNA is not efficiently polyadenylated at sequences in the 3' end of the DHFR cDNA but rather uses polyadenylation signals downstream from the DHFR cDNA.", "output": {"entities": {"gene": [{"text": "DHFR cDNA", "start": 83, "end": 92}, {"text": "DHFR cDNA", "start": 153, "end": 162}]}}, "schema": []}
{"input": "At both water temperatures, VO2 increased linearly with increasing swimming velocity.", "output": {"entities": {}}, "schema": []}
{"input": "Brief report.", "output": {"entities": {}}, "schema": []}
{"input": "Hybrid-selection experiments against total PB-inducible RNA were performed with plasmid DNA derived from clones enriched in PB-inducible information.", "output": {"entities": {}}, "schema": []}
{"input": "Risk of HTLV infection in patients on haemodialysis.", "output": {"entities": {}}, "schema": []}
{"input": "In vitro metabolism of progesterone by the human undescended testis.", "output": {"entities": {}}, "schema": []}
{"input": "Two patients withdrew from therapy, one for personal reasons and one because a paraspinal mass developed.", "output": {"entities": {}}, "schema": []}
{"input": "All patients received VCR 1. 0 mg/m2 weekly for 6 weeks with dose modification for neurotoxicity.", "output": {"entities": {}}, "schema": []}
{"input": "Glutamic acid in a dose of 1/100 of the LD50 was injected in the form of sodium salt into male and female Wistar rats for 7 days after 8-and 12-day injections of dexazone.", "output": {"entities": {}}, "schema": []}
{"input": "Serum ascorbic acid had an inverse and the strongest association with systolic blood pressure among the risk factors including blood pressure, total cholesterol, triglyceride, gamma-GTP and obesity.", "output": {"entities": {"gene": [{"text": "gamma-GTP", "start": 176, "end": 185}]}}, "schema": []}
{"input": "Effect of bromazepam on growth hormone and prolactin secretion in normal subjects.", "output": {"entities": {"gene": [{"text": "growth hormone", "start": 24, "end": 38}, {"text": "prolactin", "start": 43, "end": 52}]}}, "schema": []}
{"input": "In several cases of definite SjS, labial salivary gland examinations after more than a one year interval were performed on two occasions, and the clinical and histopathological changes were investigated.", "output": {"entities": {}}, "schema": []}
{"input": "All radiologists using the machine found that the reporting terminal was simple to operate, but found that reporting abnormalities caused an increased effort and took a longer time.", "output": {"entities": {}}, "schema": []}
{"input": "Thalamotomy aiming at the CM-Pf complex and using stereotactic gamma irradiation has been performed in a series of 52 patients with severe pain due to malignancy.", "output": {"entities": {}}, "schema": []}
{"input": "2 Silastic capsules, each containing 22-23 mg of ethinyl estradiol, were inserted subcutaneously in 5 men with benign prostatic hypertrophy.", "output": {"entities": {}}, "schema": []}
{"input": "When used subcutaneously or intravenously in maximum tolerated doses the antibiotic inhibited the development of lymphadenosis NK/Li by 90 and 70 per cent respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Effect of 2-(p-chlorophenyl) cyclopropylamine on 5-hydroxyindole concentration and monoamine oxidase activity in rat brain.", "output": {"entities": {"gene": [{"text": "monoamine oxidase", "start": 83, "end": 100}]}}, "schema": []}
{"input": "Then, pure pancreatic juice was infused into the duodenum.", "output": {"entities": {}}, "schema": []}
{"input": "An experiment was carried on 133 grown up fowls and broilers from 4 industrial farms, vaccinated with spray lento and mesogenic vaccines for straining the immunity against pseodopest through RIHA and provoking pseudoplague with a pathogenic virus.", "output": {"entities": {}}, "schema": []}
{"input": "(2) The inappropriateness of adaptive segmentation for the isolation of spikes and sharp waves, which had been anticipated in view of the short duration of such transients in relation to the length of the window (1. 2 sec) used for the autocorrelation functions employed in the segmentation algorithm, was confirmed.", "output": {"entities": {}}, "schema": []}
{"input": "The ability of chronic UM-272 (dimethylpropranolol) treatment to prevent the induction of reentrant ventricular tachyarrhythmias was assessed in the conscious dog subjected to serial programmed electrical stimulation on days 3--5 after myocardial infarction.", "output": {"entities": {}}, "schema": []}
{"input": "The effect of echothiophate on the biphasic response of rabbit ocular pressure to dipivefrin.", "output": {"entities": {}}, "schema": []}
{"input": "In most cases of acute transmural infarction, the reciprocal ST segment depressions observed in contralateral leads are less marked than the primary ST segment elevations.", "output": {"entities": {}}, "schema": []}
{"input": "Bacillus cereus cross-infection in a maternity-unit.", "output": {"entities": {}}, "schema": []}
{"input": "In the latter category particular emphasis is being placed on new anthracycline analogues of doxorubicin and analogues of cisplatinum diammine dichloride.", "output": {"entities": {}}, "schema": []}
{"input": "Late mRNA selected by a cDNA homologous to the HindIII-P/EcoRI-B region of the AcNPV map directed the synthesis of 31K and 30K proteins which comigrated with the 31K and 30K proteins translated from RNA selected by the HindIII-A/EcoRI-C/SstI-G cDNA.", "output": {"entities": {"gene": [{"text": "HindIII-P", "start": 47, "end": 56}, {"text": "EcoRI-B", "start": 57, "end": 64}, {"text": "HindIII-A", "start": 219, "end": 228}, {"text": "EcoRI-C", "start": 229, "end": 236}, {"text": "SstI-G", "start": 237, "end": 243}]}}, "schema": []}
{"input": "Intraoperatively the complement factor C3c decreased by 20%, while alpha 1-antitrypsin showed postoperatively an increase by 30%.", "output": {"entities": {"gene": [{"text": "complement factor C3c", "start": 21, "end": 42}, {"text": "alpha 1-antitrypsin", "start": 67, "end": 86}]}}, "schema": []}
{"input": "A polypeptide chain of 34 residues of the deduced yeast amino acid sequence closely resembles a peptide sequence at the ADP binding site of bovine muscle pyruvate kinase.", "output": {"entities": {"gene": [{"text": "bovine muscle pyruvate kinase", "start": 140, "end": 169}]}}, "schema": []}
{"input": "The P165 component, however, could be differentiated from the two later components since it increased in amplitude with increased task demands while the N2 and P3 amplitudes remained constant.", "output": {"entities": {}}, "schema": []}
{"input": "Differential drawing size associated with unilateral brain damage.", "output": {"entities": {}}, "schema": []}
{"input": "The intracoronary administration of both drugs markedly reduced the incidence of VF induced by the release of a 40-min coronary artery occlusion.", "output": {"entities": {}}, "schema": []}
{"input": "These fusions are contained on plasmids which have both yeast and E. coli replication origins and selectable markers and, therefore, can be used to transform either yeast or E. coli cells.", "output": {"entities": {}}, "schema": []}
{"input": "Therefore, it was concluded that thrombotic tendency certainly existed in patients with MS compared to those with non RHD and that it was one of the causes of the significantly high incidence of thromboembolism in comparison with non RHD.", "output": {"entities": {}}, "schema": []}
{"input": "Subdural electrodes may yield larger VEP amplitudes than skull or scalp electrodes.", "output": {"entities": {}}, "schema": []}
{"input": "Products of immune cells such as transfer factor and lymphokines form the third and possibly most important group of immune-stimulating agents.", "output": {"entities": {"gene": [{"text": "transfer factor", "start": 33, "end": 48}]}}, "schema": []}
{"input": "Use of the immunofluorescence method for identification of enteroviruses in cell cultures", "output": {"entities": {}}, "schema": []}
{"input": "This fraction is resistant to digestions by DNase I and RNase T1 and disappears completely upon alkali hydrolysis.", "output": {"entities": {"gene": [{"text": "DNase I", "start": 44, "end": 51}, {"text": "RNase T1", "start": 56, "end": 64}]}}, "schema": []}
{"input": "The construction of a small library of mouse repetitive DNA has been previously reported (Pietras et al., Nucleic Acids Res.", "output": {"entities": {}}, "schema": []}
{"input": "No direct repeats flank the pseudogene in the U2/4 locus.", "output": {"entities": {"gene": [{"text": "U2/4 locus", "start": 46, "end": 56}]}}, "schema": []}
{"input": "The direct effects of transmitter release were (a) an early fall in MAP followed by a late pressor effect; and (b) an early bradycardia followed by a late tachycardia.", "output": {"entities": {}}, "schema": []}
{"input": "The number of elements and their sizes relative to the configuration were varied in a series of five experiments.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, the overall chance that a patient would undergo ET was greater in a cycle in which more than one follicle 20 mm or larger was developing than in a cycle in which a single large follicle was developing.", "output": {"entities": {}}, "schema": []}
{"input": "Five of the patients with increased L-L size had a normal A-P diameter.", "output": {"entities": {}}, "schema": []}
{"input": "Immunochemotherapy with schizophyllan (SPG) combined with chemotherapeutic agents was evaluated in two syngeneic tumor-C3H/He mouse systems.", "output": {"entities": {}}, "schema": []}
{"input": "However, when combined with mitomycin C given with 1 to 5-days interval, the concurrent administration of SPG prolonged significantly the life-span of the tumor-bearing mice.", "output": {"entities": {}}, "schema": []}
{"input": "Data are presented hinting that the 15 beta-hydroxy-, metabolite of CPA may actually be the biologically active agent.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast, in LL patients during ENL the ConA-induced suppressor response was markedly reduced.", "output": {"entities": {"gene": [{"text": "ConA", "start": 43, "end": 47}]}}, "schema": []}
{"input": "Functional characterization of a fraction identified by its activity in a second template rescue assay.", "output": {"entities": {}}, "schema": []}
{"input": "It has been established that preoperative irradiation in the form of the fractionation of a single focal dose of 6 Gy every other day, the summary dose of 24 Gy within 8-10 days followed by surgery 1-3 days after irradiation does not either complicate its performance or the course of the postoperative period, and by the short-and long-term results it is no worse than the routine dose fractionation.", "output": {"entities": {}}, "schema": []}
{"input": "Fibrin gels and their possible implication for surface hemorheology in health and disease.", "output": {"entities": {"gene": [{"text": "Fibrin", "start": 0, "end": 6}]}}, "schema": []}
{"input": "Hepatitis-B vaccination in the elderly.", "output": {"entities": {}}, "schema": []}
{"input": "Radiogallium imaging is thus of limited use in evaluation of suspected giant cell tumors of bone.", "output": {"entities": {}}, "schema": []}
{"input": "Ventricular volume stiffness vs. the mean wall stress relationship of LVH shifted upward, whereas the normalized wall muscle stiffness vs. the mean wall stress relationship of LVH showed a smaller slope.", "output": {"entities": {}}, "schema": []}
{"input": "Synthesis of (+)-lysergic acid diethylamide tartrate", "output": {"entities": {}}, "schema": []}
{"input": "Weight loss reduces arterial pressure by a decrease in intravascular volume and cardiac output associated with a fall in sympathetic activity.", "output": {"entities": {}}, "schema": []}
{"input": "The effect of treatment may thus be divided into two main phases--an initial phase with a reduction in LV mass and a reduction in cardiac output and no change in total peripheral resistance--and a second phase with a constant LV mass but an increase in cardiac output to the pretreatment level again and a concomitant decrease in total peripheral resistance.", "output": {"entities": {}}, "schema": []}
{"input": "This study was undertaken to assess the effects of hypothermia and chemical cardioplegia on the functional recovery of hypertrophied non-failing rat hearts subjected to an extended period of global ischaemia.", "output": {"entities": {}}, "schema": []}
{"input": "Oxygen profiles calculated for the Krogh model with excentric diffusion were similar to those derived for the two models of concentric diffusion.", "output": {"entities": {}}, "schema": []}
{"input": "Cultivation technics for Codonopsis pilosula", "output": {"entities": {}}, "schema": []}
{"input": "Radioimmunoassay of serum creatine kinase B isoenzyme in the diagnosis of acute myocardial infarction.", "output": {"entities": {"gene": [{"text": "creatine kinase B isoenzyme", "start": 26, "end": 53}]}}, "schema": []}
{"input": "Selective macrophage inhibition abolishes warfarin-induced reduction of metastasis.", "output": {"entities": {}}, "schema": []}
{"input": "Restriction enzyme and heteroduplex analyses confirmed that sequences unique to FeSV (src sequences) are located at the center of the FeSV genome and are approximately 1. 5 kilobase pairs in length.", "output": {"entities": {"gene": [{"text": "src sequences", "start": 86, "end": 99}]}}, "schema": []}
{"input": "Catecholamines and aversive learning: a review.", "output": {"entities": {}}, "schema": []}
{"input": "A haemolytic enterotoxigenic strain of E. coli (O149: K88: H10) was regularly recovered from piglets with PWD while rotavirus was demonstrated on a number of occasions.", "output": {"entities": {}}, "schema": []}
{"input": "The antibody titer of 202 chickens to SA-11 rotavirus was determined by enzyme-linked immunosorbent blocking assay.", "output": {"entities": {}}, "schema": []}
{"input": "Poly (dT) and denatured calf thymus DNA were more effective than were other polynucleotides tested in promoting accumulation of 19 HDP *; (dT) 8 was as effective as were longer molecules of (dT) n, but (dT) 4 and (dT) 6 were much less effective, indicating that the binding site involved in 19 HDP * accumulation covered between 6 and 8 residues of (dT) n.", "output": {"entities": {"gene": [{"text": "HDP *", "start": 131, "end": 136}, {"text": "HDP *", "start": 294, "end": 299}]}}, "schema": []}
{"input": "A double-blind trial of half-strength Polybactrin Soluble GU bladder irrigation in cystoscopy.", "output": {"entities": {}}, "schema": []}
{"input": "Thus it appears that insertion of a transposable element near the 5' terminus of the structural gene can produce constitutive expression of a normally glucose-repressed enzyme.", "output": {"entities": {}}, "schema": []}
{"input": "Five experiments examined the influence of opiate antagonists on both the short-term analgesic reaction resulting 30 min after exposure to inescapable shock and the long-term analgesic reaction resulting after reexposure to shock 24 hr after inescapable shock exposure.", "output": {"entities": {}}, "schema": []}
{"input": "Experiment 3 showed that the long-term analgesic reaction could also be reduced by administration of naltrexone prior to reexposure to shock.", "output": {"entities": {}}, "schema": []}
{"input": "A 22K polypeptide was detected as a translation product of late RNA that hybridized to this DNA fragment.", "output": {"entities": {}}, "schema": []}
{"input": "Replicating simian virus 40 (SV40) chromosomes were found to be similar to other eukaryotic chromosomes in that the rate and extent of micrococcal nuclease (MNase) digestion were greater with replicating than with nonreplicating mature SV40 chromatin.", "output": {"entities": {"gene": [{"text": "micrococcal nuclease", "start": 135, "end": 155}, {"text": "MNase", "start": 157, "end": 162}]}}, "schema": []}
{"input": "A hypothesis.", "output": {"entities": {}}, "schema": []}
{"input": "Physiology and Physiopathology", "output": {"entities": {}}, "schema": []}
{"input": "The genome of avian erythroblastosis virus contains two independently expressed genetic loci (v-erbA and v-erbB) whose activities are probably responsible for oncogenesis by the virus.", "output": {"entities": {"gene": [{"text": "v-erbA", "start": 94, "end": 100}, {"text": "v-erbB", "start": 105, "end": 111}]}}, "schema": []}
{"input": "Because RNase III host mutants are defective in sib regulation, processing of the PL mRNA at sib by this endoribonuclease may cause int mRNA decay and decrease int synthesis.", "output": {"entities": {"gene": [{"text": "RNase III host mutants", "start": 8, "end": 30}, {"text": "sib", "start": 48, "end": 51}, {"text": "PL mRNA", "start": 82, "end": 89}, {"text": "sib", "start": 93, "end": 96}, {"text": "int mRNA", "start": 132, "end": 140}, {"text": "int", "start": 160, "end": 163}]}}, "schema": []}
{"input": "At least one clone, lambda HHG 41, contains, in addition to the histone genes, a region that hybridizes with a cytoplasmic RNA approximately 330 nucleotides in length.", "output": {"entities": {"gene": [{"text": "histone genes", "start": 64, "end": 77}]}}, "schema": []}
{"input": "Both neural and hormonal pathways and both opiate and nonopiate substances play roles in the complex modulation of pain transmission.", "output": {"entities": {}}, "schema": []}
{"input": "Restoration of impaired immune functions in aging animals.", "output": {"entities": {}}, "schema": []}
{"input": "Postoperative serum ACTH levels were normal.", "output": {"entities": {"gene": [{"text": "ACTH", "start": 20, "end": 24}]}}, "schema": []}
{"input": "In fact, families of polypeptides were produced by initiation of translation at AUG codons within sequences coding for VP1 and T, presumably as a result of transcription initiation events that generated 5' ends immediately upstream from these AUGs.", "output": {"entities": {"gene": [{"text": "VP1", "start": 119, "end": 122}, {"text": "T", "start": 127, "end": 128}]}}, "schema": []}
{"input": "In addition, TRP1 RI Circle DNA is organized into nucleosomes whose size and spacing are indistinguishable from that of bulk yeast chromatin.", "output": {"entities": {"gene": [{"text": "TRP1", "start": 13, "end": 17}]}}, "schema": []}
{"input": "The frequency of previous transfusion in chronic hepatitis, cirrhosis and hepatocellular carcinoma of type NANB was 42. 8, 37. 1 and 15. 1%, respectively, whereas the incidence of early posttransfusion hepatitis was 8. 5, 8. 6 and 7. 5%, respectively. in chronic liver diseases with a history of jaundice and/or hepatitis, previous transfusions are more frequently associated with type NANB than with type B disease.", "output": {"entities": {}}, "schema": []}
{"input": "Of 115 hepatitis B patients seen at 12 months, 6% had chronic hepatitis Bs antigenaemia, 60% had developed anti-HBs antibodies, and 7. 3% still had abnormal liver function.", "output": {"entities": {"gene": [{"text": "anti-HBs antibodies", "start": 107, "end": 126}]}}, "schema": []}
{"input": "Survey on antibody against egg drop syndrome-1976 virus among chicken flocks in Japan.", "output": {"entities": {}}, "schema": []}
{"input": "In 49 patients in whom gated equilibrium ventriculography and cardiac catheterization were performed within a 6 day interval, total and fractional portions of global and regional right ventricular ejection fraction (RVEF) were correlated with pulmonary arterial systolic pressure.", "output": {"entities": {}}, "schema": []}
{"input": "74, 193-197).", "output": {"entities": {}}, "schema": []}
{"input": "The combination of MISO and WR-2721 gave an intermediate response compared with either drug used alone, resulting in some sensitization with single doses and an overall protection with repeated small doses.", "output": {"entities": {}}, "schema": []}
{"input": "Two mutations that affect larval cuticle protein gene expression in the 2/3 variant Drosophila melanogaster strain were investigated.", "output": {"entities": {"gene": [{"text": "larval cuticle protein gene", "start": 26, "end": 53}]}}, "schema": []}
{"input": "A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells.", "output": {"entities": {}}, "schema": []}
{"input": "Hybridization of plasmid-transformed Escherichia coli RR1 colonies with 32P-labeled viral genome RNAs demonstrated the presence of DNA clones representative of each of the 10 reovirus RNAs and 10 of the 11 constituent segments of the rotavirus genome.", "output": {"entities": {}}, "schema": []}
{"input": "Another sequence, GGGXGGAG, which is repeated several times in many polyomaviruses and adenoviruses, and which is thought to play a role in DNA replication and/or transcription, is not found in the JCV sequence presented.", "output": {"entities": {}}, "schema": []}
{"input": "Lung density increased in quartz-exposed, but not in volcanic-ash-exposed animals.", "output": {"entities": {}}, "schema": []}
{"input": "The hepatitis A virus antibody (anti-HAV) in chronic diffuse liver diseases", "output": {"entities": {"gene": [{"text": "hepatitis A virus antibody", "start": 4, "end": 30}, {"text": "anti-HAV", "start": 32, "end": 40}]}}, "schema": []}
{"input": "The junctions between viral and cellular sequences were determined by DNA sequence analysis to be 517 nucleotides into the p30 sequence and 1, 920 nucleotides into the polymerase sequence.", "output": {"entities": {"gene": [{"text": "p30 sequence", "start": 123, "end": 135}]}}, "schema": []}
{"input": "Naloxone (2 mg/kg bolus + 2 mg X kg-1 X h-1) was given with one of the two doses of the lipopolysaccharide.", "output": {"entities": {}}, "schema": []}
{"input": "I.", "output": {"entities": {}}, "schema": []}
{"input": "Viral RNA, molecularly cloned proviral DNA, and virus-specific protein of avian retrovirus MH2 were analyzed.", "output": {"entities": {}}, "schema": []}
{"input": "Intracellular recordings were performed on the optic tectum of the carp in vitro.", "output": {"entities": {}}, "schema": []}
{"input": "Molecular structure and evolutionary origin of human cardiac muscle actin gene.", "output": {"entities": {"gene": [{"text": "human cardiac muscle actin gene", "start": 47, "end": 78}]}}, "schema": []}
{"input": "The mutants were obtained by substitution into a molecular clone of M-MuLV DNA by DNA from two acutely transforming viruses, Ableson MuLV (Ab-MuLV) and Moloney murine sarcoma virus (M-MSV).", "output": {"entities": {}}, "schema": []}
{"input": "Plasmids for the cloning and expression of full-length double-stranded cDNAs under control of the SV40 early or late gene promoter.", "output": {"entities": {"gene": [{"text": "SV40 early", "start": 98, "end": 108}, {"text": "late gene", "start": 112, "end": 121}]}}, "schema": []}
{"input": "Supplementing a soybean protein and sucrose-based diet with levels of 2. 2, 11, and 55 ppm of the antibiotic, from the two sources each with two different purities, improved weight gain of chicks an average of 23% and improved feed efficiency an average of 13% at the higher levels (all P less than. 01).", "output": {"entities": {}}, "schema": []}
{"input": "Overall prevalences of antibody were 70 per cent in cattle, 67 per cent in sheep and 76 per cent in goats as assessed by an immunodiffusion test.", "output": {"entities": {}}, "schema": []}
{"input": "Expression of herpes simplex virus beta and gamma genes integrated in mammalian cells and their induction by an alpha gene product.", "output": {"entities": {}}, "schema": []}
{"input": "The splice acceptor site is ca.", "output": {"entities": {}}, "schema": []}
{"input": "This is consistent with a model proposing that SSV was generated by recombination between proviral DNA of a simian sarcoma associated virus and proto-sis and that introns were spliced out subsequently from a fused viral-sis messenger RNA.", "output": {"entities": {"gene": [{"text": "proto-sis", "start": 144, "end": 153}, {"text": "viral-sis messenger RNA", "start": 214, "end": 237}]}}, "schema": []}
{"input": "We conclude that, with autonomic nervous system activity intact, carotid chemoreceptor reflex activation can elicit an absolute reflexly mediated reduction in coronary blood flow in the normal, conscious dog, despite an increase in arterial pressure.", "output": {"entities": {}}, "schema": []}
{"input": "Female subjects, including both normal subjects and idiopathic calcium stone-formers, have higher urinary cyclic AMP levels than their male counterparts, and this difference is significant when urinary cyclic AMP is expressed in the units mumol/g of creatinine.", "output": {"entities": {}}, "schema": []}
{"input": "We conclude that the' morning dip' observed in asthmatic patients cannot simply be explained by changes in cell receptor number or affinity, as our results suggest that both groups have intact beta-adrenoceptor function.", "output": {"entities": {"gene": [{"text": "beta-adrenoceptor", "start": 193, "end": 210}]}}, "schema": []}
{"input": "The effect of desipramine probably represents inhibition of neuronal uptake and that of amitriptyline and mianserin blockade of neuronal uptake and prejunctional alpha 2-adrenoreceptors.", "output": {"entities": {"gene": [{"text": "alpha 2-adrenoreceptors", "start": 162, "end": 185}]}}, "schema": []}
{"input": "We conclude that the gp54 structural gene is required for initiation or amplification of the splenic erythroblast hyperplasia which characterizes the preleukemic phase of Rauscher disease.", "output": {"entities": {"gene": [{"text": "gp54 structural gene", "start": 21, "end": 41}]}}, "schema": []}
{"input": "Surgical treatment of pulmonary metastases.", "output": {"entities": {}}, "schema": []}
{"input": "A promoter sequence (Goldberg-Hogness or TATA box) is situated 28 base pairs upstream from the point of initiation of transcription which was found by S1 nuclease mapping and by oligonucleotide-primed reverse transcription of rat PTH mRNA.", "output": {"entities": {"gene": [{"text": "S1 nuclease", "start": 151, "end": 162}, {"text": "rat PTH mRNA", "start": 226, "end": 238}]}}, "schema": []}
{"input": "Each of these spliced mRNAs has an untranslated leader sequence of 249 bases and a single intron of approximately 540 bases which are contained entirely within TRs/IRs sequences.", "output": {"entities": {}}, "schema": []}
{"input": "The expression of chloramphenicol acetyltransferase was detected within 1 h after infection of cells with recombinant virus, reflecting the early nature of the promoters used.", "output": {"entities": {"gene": [{"text": "chloramphenicol acetyltransferase", "start": 18, "end": 51}]}}, "schema": []}
{"input": "NPT II synthesis, measured by agar plate assays of kanamycin resistance and by immunoprecipitation of the NPT II protein, was repressed in the presence of cysteine and derepressed in its absence.", "output": {"entities": {"gene": [{"text": "NPT II", "start": 0, "end": 6}, {"text": "NPT II protein", "start": 106, "end": 120}]}}, "schema": []}
{"input": "A computed tomographic scan obtained after EOE-13 infusion accurately showed the perfusion pattern of the implanted catheter.", "output": {"entities": {}}, "schema": []}
{"input": "The 12, 000 MW (12K) IE polypeptide encoded by IEmRNA-5 is translated from an 88 codon open reading frame, leaving a 1200 base 3' non-translated region.", "output": {"entities": {"gene": [{"text": "12, 000 MW (12K) IE polypeptide", "start": 4, "end": 35}, {"text": "IEmRNA-5", "start": 47, "end": 55}]}}, "schema": []}
{"input": "The greatest difference between the Ad7 and Ad5 DBPs is the absence, in the Ad7 protein, of 12 amino acids located between the two functional domains in the Ad5 protein (amino acids 151-162).", "output": {"entities": {"gene": [{"text": "Ad7 and Ad5 DBPs", "start": 36, "end": 52}]}}, "schema": []}
{"input": "No significant correlation was found between LVM or wall thickness and body surface area, age, blood pressure, heart rate, cardiac output, total peripheral resistance and left ventricular systolic wall stress, whereas CD25 was correlated with urinary catecholamines only in hypertensive patients (r = 0. 606, p less than 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, no Shine-Dalgarno sequences are present upstream of the presumed translational start codons.", "output": {"entities": {}}, "schema": []}
{"input": "The gene cat-86, specifying chloramphenicol-inducible chloramphenicol acetyltransferase, is located on the 1. 1-kilobase cloned DNA.", "output": {"entities": {"gene": [{"text": "gene cat-86", "start": 4, "end": 15}, {"text": "chloramphenicol-inducible chloramphenicol acetyltransferase", "start": 28, "end": 87}]}}, "schema": []}
{"input": "The myeloproliferative sarcoma virus (MPSV) was derived by passage of Moloney sarcoma virus (Mo-MuSV) in adult mice.", "output": {"entities": {}}, "schema": []}
{"input": "The same-sized EBNA protein (approximately 78, 000) was made after transfection with BamHI-K (5. 2 kilobase pairs [kbp]) or the I1f subfragment (2. 9 kbp).", "output": {"entities": {"gene": [{"text": "EBNA protein (approximately 78, 000)", "start": 15, "end": 51}, {"text": "BamHI-K (5. 2 kilobase pairs [kbp])", "start": 85, "end": 120}]}}, "schema": []}
{"input": "They generated ca.", "output": {"entities": {}}, "schema": []}
{"input": "Here we have determined the nucleotide sequence of 3. 5 kb from the 3' end of delta gag to the 3' end of molecularly cloned proviral MH2 DNA, in order to elucidate the genetic structure of the virus and to compare it with other mht-and myc-containing oncogenic viruses as well as with the chicken proto-myc gene.", "output": {"entities": {"gene": [{"text": "delta gag", "start": 78, "end": 87}, {"text": "mht", "start": 228, "end": 231}, {"text": "myc", "start": 236, "end": 239}, {"text": "chicken proto-myc gene", "start": 289, "end": 311}]}}, "schema": []}
{"input": "USA 80, 802-806] was used to isolate a genomic clone lambda PGK-1 containing a portion of an autosomal locus for phosphoglycerate kinase (PGK).", "output": {"entities": {"gene": [{"text": "PGK-1", "start": 60, "end": 65}, {"text": "phosphoglycerate kinase", "start": 113, "end": 136}, {"text": "PGK", "start": 138, "end": 141}]}}, "schema": []}
{"input": "A.", "output": {"entities": {}}, "schema": []}
{"input": "188 patients received cimetidine 400 mg q. i. d. intravenously and 1, 000 mg daily orally in divided doses.", "output": {"entities": {}}, "schema": []}
{"input": "An immunologic test using stomach and tumor antigens for screening of those at high risk for stomach cancer is suggested.", "output": {"entities": {}}, "schema": []}
{"input": "Thirty isolates of Haemophilus influenzae type b were obtained during an outbreak of invasive H. influenzae type b disease and were classified by the electrophoretic profile of their lipopolysaccharide (LPS).", "output": {"entities": {}}, "schema": []}
{"input": "Tiaprofenic acid overdose.", "output": {"entities": {}}, "schema": []}
{"input": "Frog type I (Ft I) and frog type II (Ft II) slowly adapting (SA) units produced spikes only at the indentation phase, and the threshold response phase (TRP), i. e.. the phase of the first spike was for ca.", "output": {"entities": {}}, "schema": []}
{"input": "Frog type I (Ft I) and frog type II (Ft II) slowly adapting (SA) units produced spikes only at the indentation phase, and the threshold response phase (TRP), i. e.. the phase of the first spike was for ca.", "output": {"entities": {}}, "schema": []}
{"input": "DMCM also permits extension of the possibilities of obtaining and transplanting donor organs.", "output": {"entities": {}}, "schema": []}
{"input": "Grimelius stain was positive, Masson Fontana stain negative.", "output": {"entities": {}}, "schema": []}
{"input": "Blood glucose and plasma insulin were measured at zero time and then at 15, 30, 60, 90 and 120 min after ingestion of 25 g glucose, fructose or lactose, or 30 g honey, 50 g white bread, 125 g white rice or potatoes, 150 g apples or 260 g carrots.", "output": {"entities": {"gene": [{"text": "insulin", "start": 25, "end": 32}]}}, "schema": []}
{"input": "Clinical use of absorbable polyglycolic acid suture in Blalock-Taussig' s operation", "output": {"entities": {}}, "schema": []}
{"input": "Among these are: (1) Is there sufficient understanding of family pathophysiology, of the sensitivity and specificity of diagnostic techniques and of the safety and efficacy of therapeutic modalities to make true family health care possible? (2) If this type of care is possible, how are the needs of the family and its individual members met, or value judgements made about their relative importance? and (3) What are the consequences for the health care delivery system of this type of care? An extensive literature review is used in an attempt to answer these queries, from which questions for further study are posed.", "output": {"entities": {}}, "schema": []}
{"input": "In patients in group A (\" normal \" CI), the CI, heart rate and the mean circumferential fiber shortening velocity (mVCF) were normal, but the TPR was increased significantly.", "output": {"entities": {}}, "schema": []}
{"input": "Immunologically reactive insulin levels were determined in freely-moving normal rats offered three different test-meals.", "output": {"entities": {"gene": [{"text": "insulin", "start": 25, "end": 32}]}}, "schema": []}
{"input": "These results indicate that both naturally acquired and passive (modified immune serum globulin) antibodies to type III group B Streptococcus antigen are partially protective against intra-amniotic infection.", "output": {"entities": {"gene": [{"text": "immune serum globulin", "start": 74, "end": 95}, {"text": "type III group B Streptococcus antigen", "start": 111, "end": 149}]}}, "schema": []}
{"input": "In the posthospital phase of AMI, as well as in CCHD, the occurrence of high-grade VPBs usually indicates more advanced degrees of both coronary and left ventricular disease as well as the possibility of cardiac and/or sudden death.", "output": {"entities": {}}, "schema": []}
{"input": "The genes at each locus are divergently transcribed and the coding sequences are separated by 646 base-pairs at one locus and 676 base-pairs at the other.", "output": {"entities": {}}, "schema": []}
{"input": "The enzymic hydrolysis of urea produces ammonia which causes a vivid yellow to purple colour change in the pH indicator.", "output": {"entities": {}}, "schema": []}
{"input": "The clinical efficacy rates evaluated in 151 cases (KS-R1 group in 77 cases, oral group in 74 cases) on standard criteria of committee members were 88. 3% for the KS-R1 group and 86. 5% for the oral group, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Side effect including subjective and objective symptoms were strictly evaluated in 163 cases (KS-R1 group in 83 cases, oral group in 80 cases), but the incidence rate which was 22. 9% for the KS-R1 group and 23. 8% for the oral group showed no significant difference.", "output": {"entities": {}}, "schema": []}
{"input": "Plasma renin activity did not change in response to head-up tilt or isoprenaline infusion in the patients.", "output": {"entities": {"gene": [{"text": "renin", "start": 7, "end": 12}]}}, "schema": []}
{"input": "Martin Luther and his physicians.", "output": {"entities": {}}, "schema": []}
{"input": "Enhancement of the immune response by aspecific action of vaccine additives in the aerogenic immunization of swine against swine plague", "output": {"entities": {}}, "schema": []}
{"input": "Induced gamma-ray spectroscopy", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of proteins synthesized by plasmids containing deleted forms of the trfA region indicates that the A2 protein is the essential trfA-encoded replication protein of plasmid RK2.", "output": {"entities": {"gene": [{"text": "trfA region", "start": 77, "end": 88}, {"text": "A2 protein", "start": 108, "end": 118}, {"text": "trfA-encoded replication protein", "start": 136, "end": 168}]}}, "schema": []}
{"input": "Effects of negative pleural pressure on left ventricular hemodynamics.", "output": {"entities": {}}, "schema": []}
{"input": "Resting plasma norepinephrine (NE) and epinephrine (E) levels were lower during active therapy than 2 wk after withdrawal (guanfacine and control: plasma NE, 0. 27 +/-0. 03/0. 64 +/-0. 13 ng/ml; plasma E, 0. 09 +/-0. 02/0. 17 +/-0. 05 ng/ml).", "output": {"entities": {}}, "schema": []}
{"input": "Renal response to captopril in severe heart failure: role of furosemide in natriuresis and reversal of hyponatremia.", "output": {"entities": {}}, "schema": []}
{"input": "Lauciello describes a technique for the placement of functionally generated amalgam stops as restorations within mandibular acrylic teeth.", "output": {"entities": {}}, "schema": []}
{"input": "Eleven biopsy specimens (five papules and six dusky or crusted lesions) from four patients with pityriasis lichenoides et varioliformis acuta (PLEVA) were studied by direct immunofluorescence and immunoperoxidase technics.", "output": {"entities": {"gene": [{"text": "immunoperoxidase", "start": 196, "end": 212}]}}, "schema": []}
{"input": "These data suggest that a major part of the reduction in food intake in hyperphagic rats eating a quinine-adulterated diet is due to postingestional events.", "output": {"entities": {}}, "schema": []}
{"input": "The aspirate from a parathyroid cyst was watery clear and contained high amount of parathyroid hormone.", "output": {"entities": {"gene": [{"text": "parathyroid hormone", "start": 83, "end": 102}]}}, "schema": []}
{"input": "EGV had no detectable effect on PP secretion under basal or stimulated conditions.", "output": {"entities": {"gene": [{"text": "PP", "start": 32, "end": 34}]}}, "schema": []}
{"input": "The numerous tests demonstrate that the HDL-2M can be extensively and successfully used for therapy of insulin-dependent diabetes mellitus in clinical practice.", "output": {"entities": {"gene": [{"text": "insulin", "start": 103, "end": 110}]}}, "schema": []}
{"input": "Lung prostacyclin production may be related to flow.", "output": {"entities": {}}, "schema": []}
{"input": "For the first 30 min following insulin administration, the rate of change in glucose levels was significantly less among the patients with major depressive disorder than among either the patients with dysthymic disorder or the normal control subjects.", "output": {"entities": {"gene": [{"text": "insulin", "start": 31, "end": 38}]}}, "schema": []}
{"input": "Management of hypertension in the elderly.", "output": {"entities": {}}, "schema": []}
{"input": "Transplantation of kidneys of juvenile donors in adult recipients.", "output": {"entities": {}}, "schema": []}
{"input": "Ten patients with advanced, diffuse Hodgkin' s and non-Hodgkin' s lymphomas responding poorly to the most widely employed primary chemotherapy regimens were treated with a high-dose chemotherapy (HDC) followed by rescue with non-frozen autologous bone marrow infusion (ABMT).", "output": {"entities": {}}, "schema": []}
{"input": "Effect of proteolytic enzymes and polypeptides on the antacid activity of almagate and other antacids.", "output": {"entities": {}}, "schema": []}
{"input": "Results of a controlled study", "output": {"entities": {}}, "schema": []}
{"input": "Hydrallazine also caused a slight increase in plasma renin activity and urinary excretion of noradrenaline.", "output": {"entities": {"gene": [{"text": "plasma renin", "start": 46, "end": 58}]}}, "schema": []}
{"input": "Urease activity of 97% of these organisms became evident within 30 min.", "output": {"entities": {"gene": [{"text": "Urease", "start": 0, "end": 6}]}}, "schema": []}
{"input": "After description of his short life and an explanation of the light conductor Bozzini' s merit is emphasized, by his invention as first physician to have made accessible to medicine endoscopic diagnostic possibilities.", "output": {"entities": {}}, "schema": []}
{"input": "The effect of lithium on the osmoregulation of arginine vasopressin secretion.", "output": {"entities": {"gene": [{"text": "arginine vasopressin", "start": 47, "end": 67}]}}, "schema": []}
{"input": "Antithrombin III (AT III) is a plasma protein which acts as the principal inhibitor of thrombin and is a major modulator of intravascular coagulation.", "output": {"entities": {"gene": [{"text": "Antithrombin III", "start": 0, "end": 16}, {"text": "AT III", "start": 18, "end": 24}, {"text": "thrombin", "start": 87, "end": 95}]}}, "schema": []}
{"input": "Eighteen patients were untreated, and 8 had been given previous treatment with depot testosterone 100 mg intramuscularly every 2-3 weeks for an average duration of 4. 7 years.", "output": {"entities": {}}, "schema": []}
{"input": "195mPt-labeled cisplatin was administered iv and ip to control mice and to mice bearing Sarcoma 180.", "output": {"entities": {}}, "schema": []}
{"input": "New beta-blocking drugs have been introduced which may prove beneficial in certain clinical situations since they exert more selective blockade of the cardiac receptors (beta1) as opposed to smooth muscle receptors (beta2).", "output": {"entities": {"gene": [{"text": "cardiac receptors", "start": 151, "end": 168}, {"text": "beta1", "start": 170, "end": 175}, {"text": "smooth muscle receptors", "start": 191, "end": 214}, {"text": "beta2", "start": 216, "end": 221}]}}, "schema": []}
{"input": "In the 37 patients without lung disease respiratory muscle weakness was accompanied by significant decreases in vital capacity, total lung capacity, and maximum voluntary ventilation; by significant increases in residual volume and arterial carbon dioxide tension (PaCO2); and greater likelihood of dependence on ventilators, atelectasis, and pneumonia.", "output": {"entities": {}}, "schema": []}
{"input": "Commun.", "output": {"entities": {}}, "schema": []}
{"input": "Total cumulative doses of doxorubicin ranged from 145 to 625 mg./m. 2.", "output": {"entities": {}}, "schema": []}
{"input": "Movement programming depends on understanding of behavioral requirements.", "output": {"entities": {}}, "schema": []}
{"input": "Following 20 min of steady state anaesthesia during which measurements of IOP, arterial pressure, heart rate, FIO2, FE' CO2 and CVP were recorded, one group of patients received atracurium 0. 45 mg kg-1 and the other pancuronium 0. 1 mg kg-1.", "output": {"entities": {}}, "schema": []}
{"input": "Gonadotropin levels in mothers who have had two sets of DZ twins.", "output": {"entities": {"gene": [{"text": "Gonadotropin", "start": 0, "end": 12}]}}, "schema": []}
{"input": "Freezing of plasma to obtain better yield of factor VIII: C.", "output": {"entities": {"gene": [{"text": "factor VIII", "start": 45, "end": 56}]}}, "schema": []}
{"input": "These children were grouped into four diagnostic categories: 1) idiopathic GH deficiency (n = 10); 2) organic hypopituitarism (n = 7); 3) intrauterine growth retardation (n = 5); and 4) constitutional delay of growth and/or familial short stature (n = 18), by standard clinical criteria and physiological and pharmacological tests of GH reserve.", "output": {"entities": {"gene": [{"text": "GH", "start": 75, "end": 77}, {"text": "GH", "start": 334, "end": 336}]}}, "schema": []}
{"input": "Each patient had measurable LH and FSH levels, with pulsed nocturnal secretion, and pubertal LH and FSH responses to LRH.", "output": {"entities": {"gene": [{"text": "LH", "start": 28, "end": 30}, {"text": "FSH", "start": 35, "end": 38}, {"text": "LH", "start": 93, "end": 95}, {"text": "FSH", "start": 100, "end": 103}, {"text": "LRH", "start": 117, "end": 120}]}}, "schema": []}
{"input": "These changes were the result of a decrease in afterload: mean aortic pressure fell from 85 +/-11. 8 to 68 +/-19. 6 mmHg (p less than 0. 01) and systemic arterial resistance fell from 2 886 +/-745 to 2 010 +/-610 dynes/cm-5/sec/m-2 (p less than 0. 01).", "output": {"entities": {}}, "schema": []}
{"input": "Cimetidine 800 mg given at night is as effective as 400 mg twice daily; the single dose regimen may improve patient compliance, thus facilitating treatment.", "output": {"entities": {}}, "schema": []}
{"input": "Ceftazidime shows promise as single-agent therapy for serious gram-negative bacillary infections.", "output": {"entities": {}}, "schema": []}
{"input": "Regional CBF was determined by clearance of xenon 133 in 67 patients undergoing coronary bypass grafting procedures.", "output": {"entities": {}}, "schema": []}
{"input": "Our results indicate that serum BGP is a valuable measurement of bone metabolism.", "output": {"entities": {"gene": [{"text": "serum BGP", "start": 26, "end": 35}]}}, "schema": []}
{"input": "The management of the \" chronic \" patient.", "output": {"entities": {}}, "schema": []}
{"input": "Study of bacterial motility and rate of movement using a closed circuit television", "output": {"entities": {}}, "schema": []}
{"input": "Finding of Rhodnius prolixus Stal, 1859, in babassu palm trees", "output": {"entities": {}}, "schema": []}
{"input": "Each causative organism has a species-specific preference and requirement for temperature, salinity, pH, the basic nutrients, and growth factors, and the toxin formation is affected by these environmental factors.", "output": {"entities": {}}, "schema": []}
{"input": "Deformities of the tip of the olecranon and of the coronoid process are also described (De Palma 1956, Jordan 1958, Ahlberg 1965, Weseloh 1973).", "output": {"entities": {}}, "schema": []}
{"input": "There was significant correlation of LVM/M2 and PWVn for pre-AVR and post AVR studies.", "output": {"entities": {}}, "schema": []}
{"input": "Statokinesimetric recording in Huntington choreas", "output": {"entities": {}}, "schema": []}
{"input": "The development and histostructural organization of intrahepatic biliary ducts were studied on a human embryofetal material 6 to 32 weeks old.", "output": {"entities": {}}, "schema": []}
{"input": "It has been shown in an animal experiment that alterations of the renal vasculature and parenchyma after hemostasis performed by Infrared-Contact-Coagulation are best shown by intravital magnification angiography (magnification factor 2. 22).", "output": {"entities": {}}, "schema": []}
{"input": "Cardiovascular and adrenal medullo-sympathetic reactions to acute tobacco poisoning", "output": {"entities": {}}, "schema": []}
{"input": "Intravenous injections of SG-75 (0. 03-1 mg/kg) decreased systemic blood pressure (SBP) and increased peripheral (coronary, renal, mesenteric and femoral) blood flow (PBF) dose-dependently.", "output": {"entities": {}}, "schema": []}
{"input": "In doses of 0. 03-0. 3 mg/kg i. v., SG-75 did not significantly affect pulse pressure, heart rate, aortic blood flow, left ventricular pressure (LVP) and LVdP/dt max.", "output": {"entities": {}}, "schema": []}
{"input": "Resting VE in the luteal phase was 7. 8% greater than that in the follicular phase.", "output": {"entities": {}}, "schema": []}
{"input": "Exposure of endothelium to pulsatile shear stresses that followed a tape recording of physiological flow waveforms (electromagnetic flowmeter) did not cause gross injury or denudation even when peak shear exceeded 1500 dyne/cm2.", "output": {"entities": {}}, "schema": []}
{"input": "Modern cancer therapy has included surgery, radiotherapy, chemotherapy, and most recently, immunotherapy and hyperthermia.", "output": {"entities": {}}, "schema": []}
{"input": "There was a close correlation between plasma clearance of NT by 10-hydroxylation and the D metabolic ratio (D/4-OH-D in urine) in the Ghanaians (rs =-0. 95; P less than 0. 01) and Swedes (rs =-0. 84; P less than 0. 01).", "output": {"entities": {}}, "schema": []}
{"input": "The response properties of cat horizontal canal afferents (N = 81) were characterized by three parameters: their long time constants (tau), low frequency gain constants (G1), and middle frequency gain constants (Gm).", "output": {"entities": {}}, "schema": []}
{"input": "Despite supraphysiologic E2 concentrations, however, cervical mucus scores were significantly reduced in the CC-treated group (P less than 0. 01).", "output": {"entities": {}}, "schema": []}
{"input": "Stimulation of the caudate nucleus' dophamine-reactive system in dogs by means of administration of dophamine (60 micrograms) and phenamine led to deterioration of conditioned and unconditioned components of feeding behaviour.", "output": {"entities": {}}, "schema": []}
{"input": "Value of urine glucose tests in the management of type II diabetes mellitus.", "output": {"entities": {}}, "schema": []}
{"input": "This experiment was conducted to determine if the sex or actual egg production was the important factor. (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {}}, "schema": []}
{"input": "A pharmacokinetic study of apalcillin was performed in 12 patients in an intensive-care unit.", "output": {"entities": {}}, "schema": []}
{"input": "Thrombocyte function was impaired in all patients, characterized by a diminished platelet shape change.", "output": {"entities": {}}, "schema": []}
{"input": "The findings demonstrate that AMPH administration induces a significant increase in the height of a major electroactive peak in the caudate nucleus of pigtail monkeys, and further that such amphetamine-induced increases can be manipulated by altering the affective and/or emotional state of the animal.", "output": {"entities": {}}, "schema": []}
{"input": "In two experiments, neonatal female BALB/cCrgl or BALB/cfC3HCrgl mice were given subcutaneous injections of 5 micrograms 17 beta-estradiol or sesame oil for the first 3 days of life and were ovariectomized at 60 days of age, at which time vaginal concretions (Experiments I and II) or silica (Experiment II) were implanted intravaginally.", "output": {"entities": {}}, "schema": []}
{"input": "For 228 of 425 deaths (54%) occurring among 26 100 people of known age in the Malumfashi area of northern Nigeria, data were collected on symptoms present prior to death.", "output": {"entities": {}}, "schema": []}
{"input": "Salivary estradiol 17 beta (E2-17 beta) and progesterone (P) were determined by using radioimmunoassay techniques in 30 pregnant females in the first, second and third trimesters as well as in 10 non-pregnant controls during the luteal phase of the menstrual cycle.", "output": {"entities": {}}, "schema": []}
{"input": "Other than d 7, there was no significant effect on the number of implants.", "output": {"entities": {}}, "schema": []}
{"input": "Variable FHR decelerations or bradycardias were encountered on 95 nonstress tests (18. 8%) in 80 (33. 5%) postdate patients.", "output": {"entities": {}}, "schema": []}
{"input": "The response chain in each component was maintained by food presentation under a fixed-ratio schedule.", "output": {"entities": {}}, "schema": []}
{"input": "The results imply that kindling does not produce its facilitating effect on acquisition of HPC SS by removing a disruptive effect of the stimulation.", "output": {"entities": {}}, "schema": []}
{"input": "The persistent fetal dispersion of nodal and Hiss bundle fragments within the ventricular septum is proposed as a possible explanation.", "output": {"entities": {}}, "schema": []}
{"input": "According to the biochemical tests, high activity (over 200 U/l) of alkaline phosphatase was recorded exclusively in patients with the lymphogranulomatosis-induced liver damage.", "output": {"entities": {"gene": [{"text": "alkaline phosphatase", "start": 68, "end": 88}]}}, "schema": []}
{"input": "Changes of plasma cortisol level in late asthmatic responses", "output": {"entities": {}}, "schema": []}
{"input": "Significant alterations in the vasectomized rats from sham rats included: testicular and epididymal hypertrophy, formation of pathologic vas deferens granulomas, decreased total serum protein, lowered alpha-globulin levels as shown by serum electrophoresis, and increased sperm agglutinin antibody titers.", "output": {"entities": {"gene": [{"text": "alpha-globulin", "start": 201, "end": 215}, {"text": "agglutinin", "start": 278, "end": 288}]}}, "schema": []}
{"input": "SFP was significantly elevated in Hn (s).", "output": {"entities": {}}, "schema": []}
{"input": "The average birth mass of these newborns was 3491. 9 +/-2 SD 780. 5 g and that in the control group 3, 767. 5 +/-2 SD 824. 2 g (P less than 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "This machine drift, which was not associated with a rise in water phantom temperature and did not consistently correlate with estimated x-ray tube heat, could result in a significant overestimation of regional cerebral blood flow (rCBF) for a xenon/CT rCBF protocol involving 5-7 sequential scans obtained at 1-min interscan intervals.", "output": {"entities": {}}, "schema": []}
{"input": "Other uncertainties in the dosimetry at Y-12 and Vinca are unaltered.", "output": {"entities": {}}, "schema": []}
{"input": "E2 treatments elevated hen plasma TG 7. 2X, PL 5. 1X, and C 7. 2X; and pullet plasma TG 6. 8X, PL 3. 7X, and C 2. 5X.", "output": {"entities": {}}, "schema": []}
{"input": "By contrast, kidneys from rats with chronic metabolic acidosis produced significantly more NH3 than both these groups (2. 73 +/-0. 29 mumol X min-1 X g-1).", "output": {"entities": {}}, "schema": []}
{"input": "Serodiagnosis of trypanosomiasis in dromedary camels using a card agglutination test set (Testryp CATT).", "output": {"entities": {}}, "schema": []}
{"input": "Adenyl cyclase activity of gastric mucosa in patients with duodenal ulcer before and after treatment", "output": {"entities": {"gene": [{"text": "Adenyl cyclase", "start": 0, "end": 14}]}}, "schema": []}
{"input": "Proteinuria--selected physiopathological and clinical problems", "output": {"entities": {}}, "schema": []}
{"input": "However, subcutaneously administered pneumococci gave a lower mortality than pneumococci given intravenously or intraperitoneally.", "output": {"entities": {}}, "schema": []}
{"input": "Reaction of human organism to exercise.", "output": {"entities": {}}, "schema": []}
{"input": "HA resulted in decreased (p less than 0. 05) Tre (0. 4 degrees C) and HR (17 b X min-1), and increased (p less than 0. 05) Msw (16 g X m-2 X h-1) during the saline experiments.", "output": {"entities": {}}, "schema": []}
{"input": "The results obtained were as follows: The mitral valve orifice area (MVA) was significantly smaller in patients with type III of the LVIT flow velocity pattern than in patients with type I (p less than 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "Scientific cooperation of CMEA member countries has been carried out since 1974 under the sponsorship of the Cancer Research Institute, Slovak Academy of Sciences (Czechoslovakia) within the framework of CMEA.", "output": {"entities": {}}, "schema": []}
{"input": "This compares favorably to results of similarly sized melanomas treated by enucleation.", "output": {"entities": {}}, "schema": []}
{"input": "A new variant of the EMG-BFB method (multichannel) is offered which has made it possible to use the method not only for training weakened muscles and reducing spasticity in their antagonists but also for improving motor coordination.", "output": {"entities": {}}, "schema": []}
{"input": "Lymphocytes from all 3 species yielded maximum responses with a 48-hour prelabel and 12-to-16 hour postlabel incubation period at 41 C and 1: 20 blood dilution.", "output": {"entities": {}}, "schema": []}
{"input": "However, there was a difference in the quality of immunity: fever and body weight loss were seen in hamsters vaccinated with the killed-toxoplasma vaccine after they were challenge exposed with T-1 strain, whereas these changes were rarely seen in hamsters given the live-toxoplasma vaccine and then challenge exposed with RH strain.", "output": {"entities": {}}, "schema": []}
{"input": "Alternating proline/alanine sequence of beta B1 subunit originates from a repetitive DNA sequence.", "output": {"entities": {"gene": [{"text": "beta B1 subunit", "start": 40, "end": 55}]}}, "schema": []}
{"input": "The segmental and regional projections of the sciatic, tibial and common peroneal nerves to the substantia gelatinosa of the spinal cord in rats--an experimental study by means of an acid phosphatase (ACP) method.", "output": {"entities": {"gene": [{"text": "acid phosphatase", "start": 183, "end": 199}, {"text": "ACP", "start": 201, "end": 204}]}}, "schema": []}
{"input": "Removal of lipid fractions of plant extractions with hexane is recommended to avoid damage to the HPLC column.", "output": {"entities": {}}, "schema": []}
{"input": "In the Arithmetic subtest one of the items would not meet the difficulty grading shown while the last two items offer very little possibility of success for all subjects. (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {}}, "schema": []}
{"input": "The toxicological evaluation of chlorofluorocarbon 22 (CFC 22).", "output": {"entities": {}}, "schema": []}
{"input": "All patients were evaluable for toxicity and 9 for response.", "output": {"entities": {}}, "schema": []}
{"input": "Methods of clinical and experimental algesimetry are described that have been used to evaluate effects of peripherally and centrally acting analgesics.", "output": {"entities": {}}, "schema": []}
{"input": "We propose that the ambiguous discrimination required a greater time for simulus evaluation and that this was reflected in the delayed P3 latencies.", "output": {"entities": {}}, "schema": []}
{"input": "Ammonia concentration dropped significantly in all treatments, a finding which suggests a protective effect on protein nitrogen degradation to non-protein nitrogen (NH3).", "output": {"entities": {}}, "schema": []}
{"input": "In this respect C reactive protein concentrations are superior to white cell count, erythrocyte sedimentation rate, and temperature and the concentrations of antiproteases.", "output": {"entities": {"gene": [{"text": "C reactive protein", "start": 16, "end": 34}]}}, "schema": []}
{"input": "Human thyroid stimulator (HTS) in thyroid diseases", "output": {"entities": {"gene": [{"text": "Human thyroid stimulator", "start": 0, "end": 24}, {"text": "HTS", "start": 26, "end": 29}]}}, "schema": []}
{"input": "We conclude that administration of the calcium antagonist Verapamil is of no additional value in tocolytic treatment with beta-mimetics.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of ketamine on the circulatory functions and body tissue oxygenation in dogs under normal and hypovolemic conditions.", "output": {"entities": {}}, "schema": []}
{"input": "Besides, it was considered that the NPF was a useful tool for activation of velopharyngeal activity by way of visual feed-back control.", "output": {"entities": {}}, "schema": []}
{"input": "To evaluate the comparative safety of U-P and D & E, we analyzed 2, 805 U-P and 9, 572 D & E abortions at 13 to 24 menstrual weeks' gestation.", "output": {"entities": {}}, "schema": []}
{"input": "Three radiologists without knowledge of patients' data and treatment analyzed 30 angiograms with and 30 examinations without PGF.", "output": {"entities": {}}, "schema": []}
{"input": "In a man with myelomonocytic leukemia, the association of increased prostatic acid phosphatase activity in serum and the presence of typical bone lesions on roentgenography suggested the existence of disseminated prostatic carcinoma.", "output": {"entities": {"gene": [{"text": "prostatic acid phosphatase", "start": 68, "end": 94}]}}, "schema": []}
{"input": "An experimental long-term study.", "output": {"entities": {}}, "schema": []}
{"input": "No anisotropism was recorded in a tetrahydrofuran solution.", "output": {"entities": {}}, "schema": []}
{"input": "The calculated values of lambda tb at 37 degrees C and 50 per cent haematocrit were 0. 650 for the pulp, 0. 674 for the tongue, 0. 828 for the submandibular gland and 0. 881 for the gingiva of the dog. lambda cp increased and lambda tp decreased as the temperature was reduced from 37 to 4 degrees C.", "output": {"entities": {}}, "schema": []}
{"input": "As pleural thickening is seen commonly in asbestosis and may influence lung volumes and the ratio of transfer factor to effective alveolar volume, the results of these measurements were compared only in the cases showing absent or minimal pleural thickening.", "output": {"entities": {"gene": [{"text": "transfer factor", "start": 101, "end": 116}]}}, "schema": []}
{"input": "The invasive pattern of squamous cell carcinoma in the mandibular gingiva", "output": {"entities": {}}, "schema": []}
{"input": "Azygos vein abutting the posterior wall of the right main and upper lobe bronchi: a normal CT variant.", "output": {"entities": {}}, "schema": []}
{"input": "However, the history of acute severe complications from otitis media revealed a higher frequency in those individuals with alpha 1-antitrypsin deficiency as compared to normals.", "output": {"entities": {"gene": [{"text": "alpha 1-antitrypsin", "start": 123, "end": 142}]}}, "schema": []}
{"input": "All other changes at the 3-, 5-, and 6-positions, as well as the replacement of the phenyl group at position 2, caused a marked decrease of activity.", "output": {"entities": {}}, "schema": []}
{"input": "Limb allografts in rats immunosuppressed with cyclosporin A.", "output": {"entities": {}}, "schema": []}
{"input": "The method involved deproteinizing samples with two volumes of acetonitrile followed by injection of 5 microliters of deproteinized supernatant onto a C18 reversed-phase column.", "output": {"entities": {}}, "schema": []}
{"input": "Refractory periods of the AV junction were altered in a comparable fashion to conduction through the AV node.", "output": {"entities": {}}, "schema": []}
{"input": "This paper brings together data, obtained from a variety of sources, on the extent of prescription and use of psychotropic drugs in the late 1960s and early 1970s.", "output": {"entities": {}}, "schema": []}
{"input": "Sixteen patients were studied within 24 hours of resuscitation and all showed depressed right ventricular ejection (RVEF) and/or an increased end-diastolic volume (RVEDVI).", "output": {"entities": {}}, "schema": []}
{"input": "During a single LAD occlusion lasting 35 minutes (series I, n = 10) 9 microns TMs were infused immediately and 30 minutes after ligation, 15 microns TMs being infused after 15-20 minutes.", "output": {"entities": {}}, "schema": []}
{"input": "The population of between 75, 000 and 100, 000 was largely unstable, and cost per capita was $0. 95 to $1. 21.", "output": {"entities": {}}, "schema": []}
{"input": "HL 02 type oculomotor stimulator.", "output": {"entities": {}}, "schema": []}
{"input": "Four patients (group 1) had type I basement membrane nephropathy, characterized by marked thickening and lamellation of the basement membrane in a pattern resembling that of Alport' s syndrome.", "output": {"entities": {}}, "schema": []}
{"input": "Brain pH following 3 h of cerebral focal ischemia changed from a normal value of 7. 0 to 6. 5 and 6. 2 in animals studied under barbiturate and halothane anesthesia, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Our results demonstrate the importance of phosphate and calcium in influencing the secretion of PTH and CT in uremia.", "output": {"entities": {"gene": [{"text": "PTH", "start": 96, "end": 99}, {"text": "CT", "start": 104, "end": 106}]}}, "schema": []}
{"input": "Thin-layer chromatographic methods were up-dated for pharmacokinetic studies of imipramine in plasma and urine.", "output": {"entities": {}}, "schema": []}
{"input": "Increasing the cut-off point to 3 positive responses decreased the sensitivity to 81% and increased the specificity to 94%.", "output": {"entities": {}}, "schema": []}
{"input": "After clofelin administration the autoregulation borders shifted to the right i. e. towards higher AP levels.", "output": {"entities": {}}, "schema": []}
{"input": "This phenomenon may be regarded as a variant of selective individual cell death, currently referred to as apoptosis, which has not been previously reported in a case of embryonal rhabdomyosarcoma.", "output": {"entities": {}}, "schema": []}
{"input": "A combined series of patients experienced a TOL after two or more previous cesarean deliveries; the rate of vaginal delivery was 66%, and there was virtually no morbidity.", "output": {"entities": {}}, "schema": []}
{"input": "Nursing home discharges in clinical practice.", "output": {"entities": {}}, "schema": []}
{"input": "The carcinogen bioassay therefore is a very important component of the battery of toxicological tests used in hazard evaluation.", "output": {"entities": {}}, "schema": []}
{"input": "Harmful effects in animals and man may result from both deficient or excessive amounts of intake.", "output": {"entities": {}}, "schema": []}
{"input": "Angionephroscintigraphy in the diagnosis of diseases of the kidney", "output": {"entities": {}}, "schema": []}
{"input": "The analysis of the structure of the sleep period as a whole reveals that with increasing of the age the delta-wave stage (DS) of the QS (determined by defined polygraphic parameters) increases, while the paradoxical phase of sleep (PS) decreases, this change being more pronounced during the first six months than during the second ones of the first year of the life.", "output": {"entities": {}}, "schema": []}
{"input": "[82Br] MISO was prepared by irradiating samples of Br-MISO in a SLOWPOKE reactor for 2 h at a thermal neutron flux of 10 (12) n cm-2 s-1.", "output": {"entities": {}}, "schema": []}
{"input": "Morphofunctional status of the formed elements of the blood in rats subjected to different variants of combined and isolated exposure to BR-1 benzene", "output": {"entities": {}}, "schema": []}
{"input": "The liver in the severely ill", "output": {"entities": {}}, "schema": []}
{"input": "In a randomized study on 150 patients (ASA 1) undergoing induction of anaesthesia, the effects of Fentanyl (0. 1 mg), the combination of Fentanyl (0. 1 mg) and Droperidol (5 mg) (Innovar, Thalamonal) and Atropine (0. 01 mg/kg b. w.) alone on cardiocirculatory parameters were studied.", "output": {"entities": {}}, "schema": []}
{"input": "These results confirming the high validity of NOM inhibiting test in the diagnosis of tumoural hyperprolactinemic states, reveal contradictory responses to CD/LD, LD and DOM, with sustain the existence of 2 sub-group of Prolactinomas: with or without a maintained DA central tonus supporting the possibility of different etiopathogenetical factors in inducing a tumoural hyperprolactinemic states.", "output": {"entities": {}}, "schema": []}
{"input": "Low NA and A may participate in lowering the plasma renin activity which in PA in suppressed, sometimes disproportionately to the actual body sodium content.", "output": {"entities": {"gene": [{"text": "plasma renin", "start": 45, "end": 57}]}}, "schema": []}
{"input": "Amikacin concentrations in serum and blister fluid in healthy volunteers and in patients with renal impairment.", "output": {"entities": {}}, "schema": []}
{"input": "The subgroup innervating the medial rectus lies exclusively along the medial face of the oculomotor nucleus, with no aberrant neurons in the medial longitudinal fasciculus, as have been found in other mammals.", "output": {"entities": {}}, "schema": []}
{"input": "Hepatitis B vaccination strategy for health-care workers in a country of intermediate hepatitis B endemicity.", "output": {"entities": {}}, "schema": []}
{"input": "An intravenous drip infusion of AMK in adequate dosage would be beneficial to use against some infectious diseases of otorhinolaryngologic field.", "output": {"entities": {}}, "schema": []}
{"input": "Out of these families 74, 3% planned next pregnancy (table IX), 57, 6% wanted to have prenatal diagnosis (table VI).", "output": {"entities": {}}, "schema": []}
{"input": "The authors have tested the interference of the hemoglobin by two routine methods (Berthelot classic and Berthelot modified) for the determination of plasmatic urea.", "output": {"entities": {"gene": [{"text": "hemoglobin", "start": 48, "end": 58}]}}, "schema": []}
{"input": "Parkinsonian patients had a significantly lower prevalence of alcohol use.", "output": {"entities": {}}, "schema": []}
{"input": "These cells averaged 17 microns in diameter and reproduced by fission, forming clusters of two or four daughter cells.", "output": {"entities": {}}, "schema": []}
{"input": "Female but not male mortalities were significantly higher for cake-fed rats than for those fed diet 41B.", "output": {"entities": {}}, "schema": []}
{"input": "Urinary N-acetylglucosaminidase activity per mg creatinine did not differ significantly between groups.", "output": {"entities": {"gene": [{"text": "Urinary N-acetylglucosaminidase", "start": 0, "end": 31}]}}, "schema": []}
{"input": "The associations between sex-hormone-binding globulin capacity (SHBG), age, body mass index (BMI), and physical fitness have been studied in 34 men and 36 women.", "output": {"entities": {"gene": [{"text": "sex-hormone-binding globulin", "start": 25, "end": 53}, {"text": "SHBG", "start": 64, "end": 68}]}}, "schema": []}
{"input": "Dipetalonema (Alafilaria) hydrochoerus subgen. et sp. n.", "output": {"entities": {}}, "schema": []}
{"input": "After 1. 5 years of such photoperiodic control, all ewes were blinded by bilateral orbital enucleation.", "output": {"entities": {}}, "schema": []}
{"input": "The concentrations of C4 and C1-INH increased with advancing stage of disease and were above normal mean values in all stages.", "output": {"entities": {"gene": [{"text": "C4", "start": 22, "end": 24}, {"text": "C1-INH", "start": 29, "end": 35}]}}, "schema": []}
{"input": "Less antibacterial activity was shown toward the Gram-negative bacilli, i. e., Pseudomonas, Klebsiella-Enterobacter, Shigella, Escherichia coli, Serratia marcescens and Proteus.", "output": {"entities": {}}, "schema": []}
{"input": "The mucosal defence capacity against proteolytic leukocyte enzymes.", "output": {"entities": {}}, "schema": []}
{"input": "The apparatus consists of an Am-241 exciting source (300 mCi) and pure Ge detector (50 mm2 X 5 mm) for measuring K alpha fluorescent x-rays (28. 3 and 28. 6 KeV) emitted from exited iodine.", "output": {"entities": {}}, "schema": []}
{"input": "Ultrastructural studies of retinopathy of premature infants", "output": {"entities": {}}, "schema": []}
{"input": "The range of serum concentrations, mean values, median values, and standard deviations for each analyte are reported for males and females and for three age groups (25-44, 45-59, 60-70).", "output": {"entities": {}}, "schema": []}
{"input": "The effects of antithrombotic drugs in patients with left ventricular thrombi: assessment with indium-111 platelet imaging and two-dimensional echocardiography.", "output": {"entities": {}}, "schema": []}
{"input": "A stable interface depends on overall stress and microstress distribution on the bone, particularly trabecular bone.", "output": {"entities": {}}, "schema": []}
{"input": "Plasma NE was also low in the anephric group (289 mg/liter +/-126 (1 SD) vs 612 +/-189, P = 0. 033, resting). (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {}}, "schema": []}
{"input": "10 long-term hemodialysis patients had immediate and redistribution thallium-201 myocardial imaging performed after a course of hemodialysis.", "output": {"entities": {}}, "schema": []}
{"input": "The Prolactin levels were within the physiological norms; the responses to TRH were normal, and elevated only in a few cases.", "output": {"entities": {"gene": [{"text": "Prolactin", "start": 4, "end": 13}, {"text": "TRH", "start": 75, "end": 78}]}}, "schema": []}
{"input": "Despite total tumor resection, multiple intraperitoneal tumor nodules of varying sizes were found and resected six months and one year later.", "output": {"entities": {}}, "schema": []}
{"input": "Private hospital accreditation.", "output": {"entities": {}}, "schema": []}
{"input": "Antithrombin III in hip surgery", "output": {"entities": {"gene": [{"text": "Antithrombin III", "start": 0, "end": 16}]}}, "schema": []}
{"input": "In 14 of 21 infant hearts (66%) with aortic arch interruption between the left common carotid and left subclavian arteries (type B of Celoria and Patton), the right subclavian artery (SA) arose anomalously.", "output": {"entities": {}}, "schema": []}
{"input": "We suggest that sensitivity to photoperiod in pallid bats, as in several other mammals, is mediated by the pineal gland.", "output": {"entities": {}}, "schema": []}
{"input": "Absorption was rapid, with a mean time to peak of 39 min.", "output": {"entities": {}}, "schema": []}
{"input": "Additionally, observations that patients with mitral versus aortic regurgitation respond differently to valve replacement suggest that differences exist preoperatively between these two types of volume overload.", "output": {"entities": {}}, "schema": []}
{"input": "A case of manifest latent nystagmus of late onset in a 13-year-old girl is reported.", "output": {"entities": {}}, "schema": []}
{"input": "Within the compartment or dimension of severity of depression a subscale of the Hamilton Depression Scale (or the Melancholia Scale) was shown to have reached an instrumental perfection, e. g. as an outcome measure of antidepressant treatment.", "output": {"entities": {}}, "schema": []}
{"input": "Significant immunoglobulinuria developed prior to the development of azotemia, significantly decreased creatinine clearance, significant proteinuria (greater than or equal to 3 + dipstick or greater than or equal to 5 gm per 24-hour urine collection), or oliguria.", "output": {"entities": {}}, "schema": []}
{"input": "A total number of 1628 cases were collected from 135 medical institutions.", "output": {"entities": {}}, "schema": []}
{"input": "Epileptiform activity recorded from superficial laminae bordering layer 4, and into which layer 4' s primary projections terminate, is suppressed preferentially by phenytoin.", "output": {"entities": {}}, "schema": []}
{"input": "Is nisoldipine capable of reducing left ventricular preload? In ten anesthetized pigs, nisoldipine (2-4 micrograms X kg-1 X min-1), a calcium channel blocker structurally related to nifedipine, reduced left ventricular systolic pressure (40%) and systemic vascular resistance (35%), whereas maxLVdP/dt decreased by 20% and cardiac output was unchanged.", "output": {"entities": {}}, "schema": []}
{"input": "Monkeys were evaluated before and after unilateral and serial bilateral removal of superior temporal cortex.", "output": {"entities": {}}, "schema": []}
{"input": "Plasma lactoferrin and the blood count of polynuclear neutrophils", "output": {"entities": {"gene": [{"text": "Plasma lactoferrin", "start": 0, "end": 18}]}}, "schema": []}
{"input": "The importance of selective renal vein phlebography in the evaluation of unexplained hematuria and filing defects in the excretory urogram is illustrated.", "output": {"entities": {}}, "schema": []}
{"input": "The statistical analysis consist of the F test followed by Snedecor' s contrast test.", "output": {"entities": {}}, "schema": []}
{"input": "The pyramidal tract and Mesencephalic Reticular Formation (MRF) were stimulated before and after the transection.", "output": {"entities": {}}, "schema": []}
{"input": "No patient with bradyarrhythmia-related SCD had manifest atrioventricular block or bundle branch block.", "output": {"entities": {}}, "schema": []}
{"input": "The measurement of the areas of fibrin, of tissue and fibrinolysis, at the above mentioned times, has been effected at standard magnification (15 X) by an image analyser (Videoplan) scale 1: 8.", "output": {"entities": {"gene": [{"text": "fibrin", "start": 32, "end": 38}]}}, "schema": []}
{"input": "Diclofenac sodium-chlormezanone poisoning.", "output": {"entities": {}}, "schema": []}
{"input": "Postprandial plasma enteroglucagon concentration after 90 minutes in untreated patients correlated positively to the faecal fat excretion (r = 0. 58, p less than 0. 02).", "output": {"entities": {"gene": [{"text": "plasma enteroglucagon", "start": 13, "end": 34}]}}, "schema": []}
{"input": "Blood pressure in children.", "output": {"entities": {}}, "schema": []}
{"input": "In this study the splenectomized captive born cynomolgus appeared to be capable of supplementing rhesus as an antimalarial drug testing model.", "output": {"entities": {}}, "schema": []}
{"input": "The results showed that the sensitivity of the 3 given guinea pig strains was comparable.", "output": {"entities": {}}, "schema": []}
{"input": "Adult Amblyomma lepidum ticks fed as nymphs on this goat transmitted heartwater to a Friesian (Bos taurus) calf.", "output": {"entities": {}}, "schema": []}
{"input": "Morphine injected into the lateral ventricle of the rat produced unilateral analgesia in the formalin test, which involves continuous, moderate pain.", "output": {"entities": {}}, "schema": []}
{"input": "The maps of Case 2 showed that a maximum first appeared on the upper right back and then moved down the right side of the posterior thorax.", "output": {"entities": {}}, "schema": []}
{"input": "Urinary urate excretion, urate clearance, and fractional excretion of urate all increased significantly during water immersion, and decreased in the hour following water immersion.", "output": {"entities": {}}, "schema": []}
{"input": "Mutations in seven other lts genes do not result in the mak-phenotype.", "output": {"entities": {"gene": [{"text": "lts genes", "start": 25, "end": 34}, {"text": "mak-phenotype", "start": 56, "end": 69}]}}, "schema": []}
{"input": "Twenty-eight were excluded as gallstones were not proved: of the remainder, 21 patients received glucagon and 22 placebo.", "output": {"entities": {"gene": [{"text": "glucagon", "start": 97, "end": 105}]}}, "schema": []}
{"input": "4 Five patients died within one month of captopril and five between four and seven months, three of whom had improved to class IIM and one to IIS before death.", "output": {"entities": {}}, "schema": []}
{"input": "Regions of the translated open reading frames of cobA and the third intron of the cob gene in yeast show high amino acid homology.", "output": {"entities": {"gene": [{"text": "cobA", "start": 49, "end": 53}, {"text": "cob gene in yeast", "start": 82, "end": 99}]}}, "schema": []}
{"input": "Multiresistant strains isolated from humans in enteral toxico-infections kill orally infected mice more frequently than strains isolated in hospital infections.", "output": {"entities": {}}, "schema": []}
{"input": "Single tooth replacement with the aid of the ITI (International Team fur Implantologie) type F hollow-cylinder implant", "output": {"entities": {}}, "schema": []}
{"input": "The 13, 14-dihydro-15-keto-metabolites of PGE2 and PGF2 alpha had no statistically significant antiarrhythmic effect.", "output": {"entities": {}}, "schema": []}
{"input": "Nucleotide sequence of DNA controlling expression of genes for maltosaccharide utilization in Streptococcus pneumoniae.", "output": {"entities": {}}, "schema": []}
{"input": "Colorimetric determination of urinary iron, chelated with deferoxamine B, using a single reagent", "output": {"entities": {}}, "schema": []}
{"input": "Measurements of perfusion also showed significantly higher values under active therapy.", "output": {"entities": {}}, "schema": []}
{"input": "HLA-A and B phenotypes of 105 patients suffering from malignant melanomas were determined, with special regard for metastatic form or relapse.", "output": {"entities": {"gene": [{"text": "HLA-A and B", "start": 0, "end": 11}]}}, "schema": []}
{"input": "Trypanosoma cruzi.", "output": {"entities": {}}, "schema": []}
{"input": "The subjects of the study were 10 normal subjects and 64 patients with gastroduodenal disease.", "output": {"entities": {}}, "schema": []}
{"input": "This study represents the first published long-term follow-up regarding this mode of treatment in patients with alveolar hypoventilation.", "output": {"entities": {}}, "schema": []}
{"input": "A convenient measure of this impairment may be obtained using the ratio of urine volume (V) divided by lithium clearance (CLi).", "output": {"entities": {}}, "schema": []}
{"input": "Nitrogen balance was compared, and metabolic complications were monitored by evaluating BUN, serum creatinine, creatinine clearance, serum CO2, SGOT, SGPT, serum LDH, and serum alkaline phosphatase.", "output": {"entities": {"gene": [{"text": "SGOT", "start": 144, "end": 148}, {"text": "SGPT", "start": 150, "end": 154}, {"text": "serum LDH", "start": 156, "end": 165}, {"text": "serum alkaline phosphatase", "start": 171, "end": 197}]}}, "schema": []}
{"input": "Production of C mu RNAs, unlike mu mRNAs, does not require recombination with the joining region (JH) locus.", "output": {"entities": {"gene": [{"text": "C mu RNAs", "start": 14, "end": 23}, {"text": "mu mRNAs", "start": 32, "end": 40}, {"text": "joining region", "start": 82, "end": 96}, {"text": "JH", "start": 98, "end": 100}]}}, "schema": []}
{"input": "The 1. 9-kb C mu RNA contains the 3' sequence characteristic of secreted mu chain, whereas the longer species bear that of membrane-bound mu chin.", "output": {"entities": {"gene": [{"text": "C mu", "start": 12, "end": 16}, {"text": "mu chain", "start": 73, "end": 81}, {"text": "mu", "start": 138, "end": 140}]}}, "schema": []}
{"input": "Transcripts of the immunoglobulin C mu gene vary in structure and splicing during lymphoid development.", "output": {"entities": {"gene": [{"text": "immunoglobulin C mu gene", "start": 19, "end": 43}]}}, "schema": []}
{"input": "Non-complement-dependent sperm-immobilizing activity was also detected in the cervical mucus of several patients.", "output": {"entities": {}}, "schema": []}
{"input": "Although the mechanism of action of ICRF-159 and 187 has not been clearly defined, it is evident from both preclinical and early clinical studies that these compounds are of interest.", "output": {"entities": {}}, "schema": []}
{"input": "All 62 isolates were resistant to lincomycin, colistin, nystatin, amphotericin B, trimethoprim lactate, polymyxin B, and anisomycin.", "output": {"entities": {}}, "schema": []}
{"input": "The evaluation of amniotic fluid delta OD450 is considered to be the cornerstone of clinical management.", "output": {"entities": {}}, "schema": []}
{"input": "Host lipids in tuberculous infection.", "output": {"entities": {}}, "schema": []}
{"input": "The sympathetic neuroeffector influence on the myocardium with ATCI depends to a large measure on the intensity of the neurotransmitter biosynthesis and function of cardiomyocyte adrenoreceptors.", "output": {"entities": {}}, "schema": []}
{"input": "Lens aldose reductase in diabetic and galactosemic cataracts.", "output": {"entities": {"gene": [{"text": "Lens aldose reductase", "start": 0, "end": 21}]}}, "schema": []}
{"input": "Fenfluramine (in doses ranging from 0. 0625-4. 0 mg/kg/infusion) did not maintain self-administration behavior at or above the minimum requirement (FR 30).", "output": {"entities": {}}, "schema": []}
{"input": "In the course of Hepatitis A HBs-and HBe-antigen as well as HBc (IgM and IgG)-, HBs-and HBe-antibodies can be detected.", "output": {"entities": {"gene": [{"text": "Hepatitis A HBs-and HBe-antigen", "start": 17, "end": 48}, {"text": "HBc (IgM and IgG)-, HBs-and HBe-antibodies", "start": 60, "end": 102}]}}, "schema": []}
{"input": "The effect of the fatty acid cyclo-oxygenase inhibitor indomethacin on cerebral blood flow (CBF) and the metabolic rate for oxygen (CMRO2) was studied in paralyzed and artificially ventilated rats.", "output": {"entities": {"gene": [{"text": "fatty acid cyclo-oxygenase", "start": 18, "end": 44}]}}, "schema": []}
{"input": "The rat incisor is an excellent model system in which to study amelgenesis.", "output": {"entities": {}}, "schema": []}
{"input": "The already elevated prolactin levels in nursing women were not influenced by chronic oestradiol administration.", "output": {"entities": {"gene": [{"text": "prolactin", "start": 21, "end": 30}]}}, "schema": []}
{"input": "Morphine-dependent and control rats in an oral free-choice protocol were treated with gamma-vinyl GABA (GVG), 60, 120 and 240 mg/kg IP, for 3 days over three successive periods.", "output": {"entities": {}}, "schema": []}
{"input": "Significance of the pulmonary gas exchange reaction to physical loading in evaluating the effectiveness of mitral commissurotomy", "output": {"entities": {}}, "schema": []}
{"input": "Thyreoliberin VUFB in thyroid gammagraphy", "output": {"entities": {"gene": [{"text": "Thyreoliberin", "start": 0, "end": 13}]}}, "schema": []}
{"input": "Advances in hemophilia treatment: a hepatitis-safe factor VIII concentrate", "output": {"entities": {"gene": [{"text": "factor VIII", "start": 51, "end": 62}]}}, "schema": []}
{"input": "This study was designed to assess and compare the ability of three different forms of DSG to block EIB.", "output": {"entities": {}}, "schema": []}
{"input": "Comparison of three different preparations of disodium cromoglycate in the prevention of exercise-induced bronchospasm: a double-blind study.", "output": {"entities": {}}, "schema": []}
{"input": "LCBF in normal and hypoxic puppies was correlated with local cerebral glucose utilization (LCGU) obtained under the same experimental conditions (Duffy et al, 1982).", "output": {"entities": {}}, "schema": []}
{"input": "Phagocytosis of tubercle bacilli by macrophages.", "output": {"entities": {}}, "schema": []}
{"input": "Detection of hemophilia A carriers.", "output": {"entities": {}}, "schema": []}
{"input": "The stability of isoniazid solutions increases markedly with increasing NTA or EDTA concentration up to 1 mmol/l.", "output": {"entities": {}}, "schema": []}
{"input": "Bile bilirubin did not rise within 12 h after haem infusion a finding which warrants further investigation.", "output": {"entities": {}}, "schema": []}
{"input": "Autoimmune manipulation aids juvenile diabetes management.", "output": {"entities": {}}, "schema": []}
{"input": "Other properties of Hg-and Cd-spores were similar to those of control spores.", "output": {"entities": {}}, "schema": []}
{"input": "The decrease in HDL-cholesterol with increasing VLDL-triglycerides was relatively much larger than the concomitant decrease in apo A-I.", "output": {"entities": {"gene": [{"text": "HDL-cholesterol", "start": 16, "end": 31}, {"text": "VLDL-triglycerides", "start": 48, "end": 66}, {"text": "apo A-I", "start": 127, "end": 134}]}}, "schema": []}
{"input": "Apo A-I level was unrelated to age, but increased with ethanol consumption and decreased with adiposity.", "output": {"entities": {"gene": [{"text": "Apo A-I", "start": 0, "end": 7}]}}, "schema": []}
{"input": "The osmotic diuretic mannitol was administered to 21 patients.", "output": {"entities": {}}, "schema": []}
{"input": "Of 270 patients with well-defined drug reactions, 190 (70 per cent) gave a positive response to the mast cell test.", "output": {"entities": {}}, "schema": []}
{"input": "Selenium, as a constituent of glutathione peroxidase, plays a role in the antioxidant defense systems of the body, but other metabolic roles for selenium may yet be discovered.", "output": {"entities": {"gene": [{"text": "glutathione peroxidase", "start": 30, "end": 52}]}}, "schema": []}
{"input": "Diagnostic value of serum myoglobin in cases of neuromuscular disease", "output": {"entities": {"gene": [{"text": "serum myoglobin", "start": 20, "end": 35}]}}, "schema": []}
{"input": "At 43% blood pressure reduction, PCO2 fell by 0. 53 kPa, a decrease which could not explain the observed CBF fall of 27%.", "output": {"entities": {}}, "schema": []}
{"input": "During the last 6 months of the study a striking change in epidemiology concerning hepatitis A was seen, apparently caused by a steep increase in the incidence of this type of hepatitis among drug addicts.", "output": {"entities": {}}, "schema": []}
{"input": "Asthmatic patients showed greater responses of both parameters to adrenaline than controls indicating that long-term corticosteroid treatment enhances the acute responses of plasminogen activator and clotting factor VIII to adrenaline infusion.", "output": {"entities": {"gene": [{"text": "plasminogen activator", "start": 174, "end": 195}, {"text": "clotting factor VIII", "start": 200, "end": 220}]}}, "schema": []}
{"input": "Sulphur amino acids (g/16 g N) were higher in the isolates than in the flours.", "output": {"entities": {}}, "schema": []}
{"input": "Time shifts increase growth hormone release.", "output": {"entities": {"gene": [{"text": "growth hormone", "start": 21, "end": 35}]}}, "schema": []}
{"input": "It then merged with right ventricular wavefronts ending along the right ventricular anterior atrioventricular groove and outflow tract.", "output": {"entities": {}}, "schema": []}
{"input": "Many of these landfill operations were undertaken in the early 1950s and 1960s, when knowledge regarding the safe and prolonged containment of the waste buried was nonexistent or minimal at best.", "output": {"entities": {}}, "schema": []}
{"input": "Vesicles could be induced only with multiple exposures to UVA.", "output": {"entities": {}}, "schema": []}
{"input": "The level of contamination in the wound can be determined with the rapid biopsy fixation technique.", "output": {"entities": {}}, "schema": []}
{"input": "Self-heating after deep hypothermia (20 degrees C) causes a considerable increase in the brain tissues glutaminase activity at all studied incubation temperatures (37, 30, 20 and 10 degrees C) as compared to control rats and rats under hypothermia.", "output": {"entities": {"gene": [{"text": "glutaminase", "start": 103, "end": 114}]}}, "schema": []}
{"input": "According to Sugiura' s classification, they consisted of Type Ia in 63%, Type Ib in 11%, Type II in 11%, and Type III in 16%.", "output": {"entities": {}}, "schema": []}
{"input": "This study was undertaken to define the mechanism for the respiratory inhibition observed during high-frequency oscillatory ventilation (HFOV).", "output": {"entities": {}}, "schema": []}
{"input": "Determination of 20 alpha-hydroxy-9 beta, 10 alpha-pregna-4, 6-dien-3-one in plasma by selected ion monitoring.", "output": {"entities": {}}, "schema": []}
{"input": "A case of a dense epidermoid cyst of the suprasellar cistern is presented.", "output": {"entities": {}}, "schema": []}
{"input": "Copper treatments were assigned to simulate the different levels of copper intake that might result from differences in daily feed intake similar to the practice followed with commercial industry.", "output": {"entities": {}}, "schema": []}
{"input": "Because of a rapid development of the connective tissue scars, however, at the place of the destroyed glandular parenchyma areas, there is no normalization of the organ' s structure and function by the 42d day.", "output": {"entities": {}}, "schema": []}
{"input": "Histological signs of the flare-up reaction were already present at 6 hr after i. v. challenge and lasted for at least 4 days.", "output": {"entities": {}}, "schema": []}
{"input": "Significant GMBF reductions occurred in early shock in both treatment groups.", "output": {"entities": {}}, "schema": []}
{"input": "Of 254 children with neuroblastoma treated at St.", "output": {"entities": {}}, "schema": []}
{"input": "Penicillin-G degradation products inhibit in vitro granulopoiesis.", "output": {"entities": {}}, "schema": []}
{"input": "Plasma fibrinogen was measured by the turbidimetric method in timol turbidimetric units.", "output": {"entities": {"gene": [{"text": "fibrinogen", "start": 7, "end": 17}]}}, "schema": []}
{"input": "Five patients with type III musculoskeletal infection from nongonococcal Neisseria species were examined during a 13-month period.", "output": {"entities": {}}, "schema": []}
{"input": "Distal tubular acidification and the threshold for proximal tubular bicarbonate reabsorption were normal, as was urine concentrating capacity.", "output": {"entities": {}}, "schema": []}
{"input": "The Tullio phenomenon, fistula test, and Hennebert' s sign: clinical significance.", "output": {"entities": {}}, "schema": []}
{"input": "These results indicate that significant pulmonary metabolism of 5-HT followed by efflux of 5-HIAA into venous output occurs during single-pass circulation.", "output": {"entities": {}}, "schema": []}
{"input": "Disturbances of placental maturation, 2.", "output": {"entities": {}}, "schema": []}
{"input": "On the basis of histopathological findings, the origin of amyloid appeared to be closely related to the fibroblasts.", "output": {"entities": {}}, "schema": []}
{"input": "Serum lactate dehydrogenase and haptoglobin levels were normal, and total bilirubin was only slightly elevated.", "output": {"entities": {"gene": [{"text": "lactate dehydrogenase", "start": 6, "end": 27}, {"text": "haptoglobin", "start": 32, "end": 43}]}}, "schema": []}
{"input": "Low-dose D (0. 4-0. 8 mg) and DB (1. 0-5. 0 mg) did not significantly alter any parameter from control.", "output": {"entities": {}}, "schema": []}
{"input": "Leads from the MMWR.", "output": {"entities": {}}, "schema": []}
{"input": "The presence of visna-maedi in Italy is reported for the first time.", "output": {"entities": {}}, "schema": []}
{"input": "High levels of IC coincided with relative hypocomplementemia.", "output": {"entities": {}}, "schema": []}
{"input": "Acute type A hepatitis in three patients with chronic HBV infection.", "output": {"entities": {}}, "schema": []}
{"input": "Pathogenetic relationships between renal tubular acidosis and sodium metabolism alterations in liver cirrhosis.", "output": {"entities": {}}, "schema": []}
{"input": "5 microU/l thyrotropin: 75% (1974), 45% (1977) and 20% (1980).", "output": {"entities": {"gene": [{"text": "thyrotropin", "start": 11, "end": 22}]}}, "schema": []}
{"input": "Echosismography enables to improve the diagnosis when compared with classical sonography in about 20% of cases.", "output": {"entities": {}}, "schema": []}
{"input": "Relationships with the acquired immune deficiency syndrome.", "output": {"entities": {}}, "schema": []}
{"input": "The prevalence of CPAF was similar in type 1 and type 2 diabetes, was greater in women than in men, and was significantly greater after repeated administrations than after one single administration of chlorpropamide.", "output": {"entities": {}}, "schema": []}
{"input": "A reassessment of the prevalence data was carried out in the southern province of Uusimaa and in the western province of Vaasa, the prevalence day being January 1, 1979.", "output": {"entities": {}}, "schema": []}
{"input": "The results confirm and extend previous work by other researchers.", "output": {"entities": {}}, "schema": []}
{"input": "In patients with complete or partial remission of the tumor, the neopterine excretion dropped to normal values.", "output": {"entities": {}}, "schema": []}
{"input": "In visible tumours the best results were obtained with FB (85%) while TBN was positive in 65%.", "output": {"entities": {}}, "schema": []}
{"input": "Total PGE levels in synovial fluid remained significantly depressed in the patient group for 24 hours after the 400-mg test dose of tolmetin on day 8.", "output": {"entities": {}}, "schema": []}
{"input": "Normal rates of weight gain were seen once absorbed energy intakes reached 100-110% of requirements.", "output": {"entities": {}}, "schema": []}
{"input": "Its vasodilatory, anti-vasopressor, and platelet stabilizing effects could be expected to counteract the placental ischemia, hypertension and excessive coagulation that are seen in pre-eclampsia.", "output": {"entities": {}}, "schema": []}
{"input": "Behcet' s syndrome", "output": {"entities": {}}, "schema": []}
{"input": "Survival of 111 Indium-labelled autologous platelets was studied in 2 patients after correction of platelet count and was still found shortened.", "output": {"entities": {}}, "schema": []}
{"input": "The effect of emotional-painful stress (EPS) on myocardial extensibility and contractility was studied on an isolated rat atrium.", "output": {"entities": {}}, "schema": []}
{"input": "When O2 therapy was controlled for, the association between RBT and RLF did not achieve statistical significance (P =. 07).", "output": {"entities": {}}, "schema": []}
{"input": "This two-helix motif is thought to be involved in specific DNA sequence recognition by CAP.", "output": {"entities": {"gene": [{"text": "CAP", "start": 87, "end": 90}]}}, "schema": []}
{"input": "Statistics for nurse managers--3.", "output": {"entities": {}}, "schema": []}
{"input": "The infection rate was five times greater in patients with Hickman catheters than in those with Broviac catheters (p = 0. 01).", "output": {"entities": {}}, "schema": []}
{"input": "Setting takes place through complex formation of (NH4Mg PO4. 6H2O) n, excess reactants, and water.", "output": {"entities": {}}, "schema": []}
{"input": "Serum IgE levels in Tauranga children.", "output": {"entities": {"gene": [{"text": "Serum IgE", "start": 0, "end": 9}]}}, "schema": []}
{"input": "Use of prostaglandin F2 alpha (PGF2 alpha) in cattle breeding.", "output": {"entities": {}}, "schema": []}
{"input": "Thus it appears that the management of blood, including washing is of great importance.", "output": {"entities": {}}, "schema": []}
{"input": "Range, variations and neoplastic potential.", "output": {"entities": {}}, "schema": []}
{"input": "The scores are dependent in part on the reliability of faculty evaluations.", "output": {"entities": {}}, "schema": []}
{"input": "Study on distribution of metal in the teeth treated by iontophoresis with transparent specimens", "output": {"entities": {}}, "schema": []}
{"input": "Whereas creatine kinase activity declined exponentially from a single peak, myoglobin appeared in multiple episodes inadequately represented by a single peak value and having no clear clinical correlation.", "output": {"entities": {"gene": [{"text": "creatine kinase", "start": 8, "end": 23}, {"text": "myoglobin", "start": 76, "end": 85}]}}, "schema": []}
{"input": "Utero-placental blood flow and the effect of beta 2-adrenoceptor stimulating drugs.", "output": {"entities": {"gene": [{"text": "beta 2-adrenoceptor", "start": 45, "end": 64}]}}, "schema": []}
{"input": "Development of basophilic leukemia with trisomy 8 and atypical erythroblastosis in a patient with a history of aplastic anemia 22 years earlier", "output": {"entities": {}}, "schema": []}
{"input": "The arginyl peptide bonds that are cleaved in the conversion of human factor IX to factor IXa by factor XIa were identified as Arg145-Ala146 and Arg180-Val181.", "output": {"entities": {"gene": [{"text": "human factor IX", "start": 64, "end": 79}, {"text": "factor IXa", "start": 83, "end": 93}, {"text": "factor XIa", "start": 97, "end": 107}]}}, "schema": []}
{"input": "Alveolar growth, contemporary with dental eruption, is sufficient to compensate possible hypotrophy of maxillary bone bases.", "output": {"entities": {}}, "schema": []}
{"input": "Renal and extrarenal arterial fibromuscular hyperplasia with hypertension.", "output": {"entities": {}}, "schema": []}
{"input": "Both examinations are sensitive indicators of CNS abnormalities associated with bacterial meningeal infections and are important determinants of the therapy and ultimate prognosis of such complications.", "output": {"entities": {}}, "schema": []}
{"input": "Similar clinical evaluation of an obligate carrier revealed no ocular abnormalities.", "output": {"entities": {}}, "schema": []}
{"input": "A case of anterior cleavage syndrome in a 27-year-old female patient is described.", "output": {"entities": {}}, "schema": []}
{"input": "The daily administration of betamethasone for three weeks markedly reduced the absorption of calcium and phosphate as well as the growth rate.", "output": {"entities": {}}, "schema": []}
{"input": "Endorphins and legal issues.", "output": {"entities": {"gene": [{"text": "Endorphins", "start": 0, "end": 10}]}}, "schema": []}
{"input": "At necropsy 28 days post-inoculation, F344 rats had no gross lung lesions, even those given the maximum dose of 1. 4 X 10 (9) colony-forming units of M. pulmonis.", "output": {"entities": {}}, "schema": []}
{"input": "Aneurysmectomy and the performance of CABG were not significantly associated with postoperative ECG changes, but more bypass grafts per patient grafted appeared in the group with postoperative ECG changes, suggesting that coronary artery disease may be more severe in that group.", "output": {"entities": {}}, "schema": []}
{"input": "REV I: All vessels up to 50% stenosed have a patent graft.", "output": {"entities": {}}, "schema": []}
{"input": "Complete sequences were obtained for the three large thrombic peptides, and these were aligned by using peptides from the V8 protease digest.", "output": {"entities": {"gene": [{"text": "V8 protease", "start": 122, "end": 133}]}}, "schema": []}
{"input": "The extraction measurements were used to test for extracerebral contamination of venous outflow.", "output": {"entities": {}}, "schema": []}
{"input": "Contractile responses to norepinephrine, serotonin and potassium (K +) and relaxant responses to isoproterenol and papaverine were studied in vitro with spirally cut thoracic aortic strips from aortic coarcted hypertensive rats (AHR) 2, 6, 14 and 28 days postoperatively and compared to time-matched, sham-operated normotensive controls.", "output": {"entities": {}}, "schema": []}
{"input": "On line calculation of steroid concentrations by radioimmunoassay", "output": {"entities": {}}, "schema": []}
{"input": "Detection of congenital hypothyroidism in 26, 282 newborn infants", "output": {"entities": {}}, "schema": []}
{"input": "In rubella patients with serologic confirmation by HI, the IF test detected significant rises in 219 (99. 1%) of 221 patients and the PHA test detected antibody conversion in 68 (93%) of 73 patients.", "output": {"entities": {"gene": [{"text": "PHA", "start": 134, "end": 137}]}}, "schema": []}
{"input": "The effect of sodium saccharin in the diet on caecal microflora.", "output": {"entities": {}}, "schema": []}
{"input": "The residue functions, R (t), for C-11 CPZ and In-113m transferrin were plotted against time for selected areas of interest, and the CPZ area-weighted extraction, E (t), was computed for the same areas every 250 msec using the formula: E (t) = [RT (t)-RR (t)]/[1-RR (t)], where RT and RR are the normalized residue functions for CPZ and transferrin, respectively.", "output": {"entities": {"gene": [{"text": "transferrin", "start": 55, "end": 66}, {"text": "transferrin", "start": 337, "end": 348}]}}, "schema": []}
{"input": "Synchronous extracts showed no significant migration inhibition in allogeneic assays.", "output": {"entities": {}}, "schema": []}
{"input": "Ten days of cefadroxil therapy was used to treat 44 children with urinary tract infection and CRP values greater than or equal to 28 microgram/ml (CRP-positive group).", "output": {"entities": {"gene": [{"text": "CRP", "start": 94, "end": 97}, {"text": "CRP", "start": 147, "end": 150}]}}, "schema": []}
{"input": "Both resting blood flow (RBF) and maximal blood flow (NBF) were studied by Xenon 133 clearance.", "output": {"entities": {}}, "schema": []}
{"input": "Plasma renin concentration is significantly higher in the subcapsular venous outflow, which drains the superficial cortex, than in the deep venous outflow, which drains the inner half of the cortex and medulla of the cat kidney.", "output": {"entities": {"gene": [{"text": "Plasma renin", "start": 0, "end": 12}]}}, "schema": []}
{"input": "After acclimation, resting supine and sitting DPB decreased (P less than 0. 05) by 6 and 9 mmHg, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "In the diabetics, Ca2 + infusions induced a rise of plasma Ca2 + up to 3. 2 +/-0. 1 mmol/1 and a fall of circulating glucagon (-26. 4 +/-5. 7%; p less than 0. 001) and glucose (-23. 3 +/-3. 6%; p less than 0. 05).", "output": {"entities": {"gene": [{"text": "glucagon", "start": 117, "end": 125}]}}, "schema": []}
{"input": "Fifty-eight RMI' s occurred in the placebo group as compared to only twenty in the AC group (p less than 0. 01).", "output": {"entities": {}}, "schema": []}
{"input": "All patients in the control group showed a significant improvement in their PEFR while only 3 patients in the treated group showed an improvement.", "output": {"entities": {}}, "schema": []}
{"input": "Facts on the Economic Recovery Tax Act of 1981 for speech-language pathologists and audiologists.", "output": {"entities": {}}, "schema": []}
{"input": "From Pap to ApUp.", "output": {"entities": {}}, "schema": []}
{"input": "The relationship between the rare complications mentioned above and the pathophysiology of Bartter' s syndrome is still obscure.", "output": {"entities": {}}, "schema": []}
{"input": "Using an opsonophagocytic bacterial assay and a suckling rat model of GBS sepsis, we analyzed a modified human immunoglobulin for opsonic and protective antibody.", "output": {"entities": {"gene": [{"text": "human immunoglobulin", "start": 105, "end": 125}]}}, "schema": []}
{"input": "Glomerular lesions in renal allografts.", "output": {"entities": {}}, "schema": []}
{"input": "Commonly observed systemic toxic effects (bone marrow, gastrointestinal tract, and heart) were not seen in this study.", "output": {"entities": {}}, "schema": []}
{"input": "2.", "output": {"entities": {}}, "schema": []}
{"input": "When vascular pressure (Pvas) was raised abruptly from-5 to + 25 cmH2O by air inflation for 60 min, Px (f) became abruptly less negative, then remained stable.", "output": {"entities": {}}, "schema": []}
{"input": "(1980): Science 210, 77-72) that stimulating the crossed olivocochlear bundle (COCB) can change the magnitude of the distortion product (f2-f1) in the ear-canal sound pressure.", "output": {"entities": {}}, "schema": []}
{"input": "Rats underwent either a 90-95% JIB or a sham operation.", "output": {"entities": {}}, "schema": []}
{"input": "When the l-methadone-sensitive, opioid receptor is blocked by naloxone or tolerance has developed, than l-methadone can produce behavioral effects by a nonopioid mechanism.", "output": {"entities": {"gene": [{"text": "opioid receptor", "start": 32, "end": 47}]}}, "schema": []}
{"input": "Microwave hyperthermia-induced blood-brain barrier alterations.", "output": {"entities": {}}, "schema": []}
{"input": "Large and small medullary lesions inhibited the occurrence of target fibres in the tenotomized muscles, the smallest one being neurolysis of the dorsal roots.", "output": {"entities": {}}, "schema": []}
{"input": "In 10 control sheep mean plasma TXB2 concentration increased from 0. 39 ng/ml prebypass to about 1. 1 ng/ml at 8 and 16 min of bypass.", "output": {"entities": {}}, "schema": []}
{"input": "The respiratory rate was 13 +/-1 breaths/min with 52 +/-4% of the respiratory cycle spent in inspiration; end-tidal CO2 pressure increased by 3. 3 +/-1. 0 Torr during runs at SIP.", "output": {"entities": {}}, "schema": []}
{"input": "There was no further increase in oxygen consumption when these subjects breathed with inspiratory pressures above SIP.", "output": {"entities": {}}, "schema": []}
{"input": "We compared the volume of the pulmonary extravascular, extracellular water space using sodium and sucrose indicators in 8 normal and 11 edematous rabbit lungs by steady-state techniques.", "output": {"entities": {}}, "schema": []}
{"input": "Investigated the reliability, validity and dimensionality of scores obtained by acute psychiatric inpatients (N = 120) on the Michigan Alcoholism Screening Test adapted to assess lifetime and current symptomatology.", "output": {"entities": {}}, "schema": []}
{"input": "A simple method for measuring urinary iron following the administration of desferrioxamine (DF) is described.", "output": {"entities": {}}, "schema": []}
{"input": "During conventional hemofiltration using substitution fluid with a Na + concentration of 140 mEq/L, a decrease in extracellular fluid volume was noted whereas the intracellular fluid volume was unaltered.", "output": {"entities": {}}, "schema": []}
{"input": "Transvenous serial xeroradiography.", "output": {"entities": {}}, "schema": []}
{"input": "Recommendations to deal with these and related issues are presented.", "output": {"entities": {}}, "schema": []}
{"input": "Use of subcutaneous deferoxamine in a child with hemochromatosis associated with congenital dyserythropoietic anemia, type I.", "output": {"entities": {}}, "schema": []}
{"input": "Although noninhibitory fluid had higher mean concentrations of phosphorus and zinc, these differences did not hold after meconium-stained samples were excluded.", "output": {"entities": {}}, "schema": []}
{"input": "Selenium status of thoroughbreds in the United Kingdom.", "output": {"entities": {}}, "schema": []}
{"input": "During an 8-wk follow-up, parasites reappeared in 10 patients, 5 after each drug, between 1 and 7 wk after treatment.", "output": {"entities": {}}, "schema": []}
{"input": "Preparation of a stable phospholipid reagent for coagulation assays.", "output": {"entities": {}}, "schema": []}
{"input": "Before turnout, a morantel sustained release bolus (MSRB) was administered to each animal in the \" treated \" category.", "output": {"entities": {}}, "schema": []}
{"input": "In a longitudinal study, 14 low-risk fetuses were studied at 2-week intervals from 32 weeks of gestation onward.", "output": {"entities": {}}, "schema": []}
{"input": "Further, intracerebroventricular injections of KA resulted in the substantial loss of pyramidal cells in the whole CA3 field of the hippocampus.", "output": {"entities": {}}, "schema": []}
{"input": "Seventeen of the 35 patients were randomly chosen to receive a training program (lasting approximately 1 month) designed to establish a systematic strategy of organizing complex visual material.", "output": {"entities": {}}, "schema": []}
{"input": "The duration and the amplitude of the negative potential were greatest for completely regenerating ears with overgrowth, smaller for partially regenerating ears, and smallest for the nonregenerating ears.", "output": {"entities": {}}, "schema": []}
{"input": "Samples obtained from normal volunteers and from the great majority of the patients, excluding those with asthma, had no effect on ciliary beating.", "output": {"entities": {}}, "schema": []}
{"input": "These results suggested the possibility that the fetus played some role in the production of E3-16-G in early pregnancy.", "output": {"entities": {}}, "schema": []}
{"input": "In this way it is possible to simulate the growth function of the embryofetal curve of the length' increase of man and the curve of the mass' increase of rat.", "output": {"entities": {}}, "schema": []}
{"input": "The highest doses were found for drivers who transported large numbers of 99Mo generators.", "output": {"entities": {}}, "schema": []}
{"input": "The steepness of the standard O2 dissociation curve becomes greater during the training period (increase in Hill' s n from 2. 68 +/-0. 10 to 2. 96 +/-0. 15).", "output": {"entities": {}}, "schema": []}
{"input": "Conjugated and unconjugated phenylacetic acid and m-and p-hydroxyphenylacetic acid have been determined in the plasma of normal, healthy subjects after fasting, consumption of a meal and ingestion of deuterium labelled amine precursors, by high-resolution gas chromatography--high resolution mass spectrometry with selected ion monitoring of their trifluoroethyl-pentafluoropropionyl derivatives.", "output": {"entities": {}}, "schema": []}
{"input": "In concept II 62 patients were treated with selective vagotomy and pyloroplasty.", "output": {"entities": {}}, "schema": []}
{"input": "They consisted of behavioural disorders, tetraparesis, incontinence and oculomotor paralysis.", "output": {"entities": {}}, "schema": []}
{"input": "CSF adenosine deaminase activity (ADA) was measured at the same time.", "output": {"entities": {"gene": [{"text": "adenosine deaminase", "start": 4, "end": 23}]}}, "schema": []}
{"input": "Histamine reactivity had returned to normal in half the workers who had left their original factories, but in only one worker who had moved within her original factory.", "output": {"entities": {}}, "schema": []}
{"input": "It was also found that there is no significant difference between the prevalence of nasal carriage of S. aureus amongst the hospital staff and the patients.", "output": {"entities": {}}, "schema": []}
{"input": "Ficat and Bizou' s condylar depth index and the condylar-joint surface angle of Brattstrom are recommended as especially suitable methods of measurement.", "output": {"entities": {}}, "schema": []}
{"input": "There were no significant differences in EF between the two studies, both at rest (56. 0 +/-13. 8% vs 58. 2 +/-11. 7%, p = NS) and with exercise (51. 1 +/-17. 6% vs 54. 3 +/-17. 6%, p = NS) and a highly significant correlation was shown between the two groups of values (rest r = 0. 90, exercise r = 0. 93, p less than 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "After MOPP therapy, complete remission of Hodgkin' s disease was accompanied by normalization of the glucocerebrosidase level and disappearance of Gaucher' s cells.", "output": {"entities": {"gene": [{"text": "glucocerebrosidase", "start": 101, "end": 119}]}}, "schema": []}
{"input": "Specifically, by the type of adjuvant therapy, the median disease-free interval and survival from stage IVA for 23 patients receiving Corynebacterium parvum were 6. 9 and 19 months; for 39 patients receiving BCG, eight months and 26 months; for 24 patients receiving BCG + DTIC, eight and 17. 4 months; and for all 51 DTIC treated patients 6. 3 and 17. 8 months, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "The COP-PAWP gradient was markedly decreased in both shock and non-shock patients with pulmonary edema.", "output": {"entities": {}}, "schema": []}
{"input": "Re: A modified method for the in vivo labeling of red blood cells with Tc-99m.", "output": {"entities": {}}, "schema": []}
{"input": "A limited study in a glassware factory (As2O3 exposure) involving the measurement of total airborne arsenic, the determination of urinary arsenic, and the evaluation of hand and mouth contamination by arsenic before and after the workshift suggests that the high urinary arsenic levels (300 microgram/g creatinine) are likely to be more related to an increased oral intake from contaminated hands than to an increased absorption from the lungs.", "output": {"entities": {}}, "schema": []}
{"input": "The pia mater at the site of the entry of blood vessels into the central nervous system.", "output": {"entities": {}}, "schema": []}
{"input": "Experimental reproduction of malignant catarrhal fever in Bali cattle", "output": {"entities": {}}, "schema": []}
{"input": "1 A colonic delivery system is described to deliver orally ingested drugs to the colon and release them at that site by coating with an acrylic based resin (Eudragit S).", "output": {"entities": {}}, "schema": []}
{"input": "Administration of the dopamine agonist bromocriptine (2. 5 mg three times a day for 4 days) suppressed (P less than 0. 01) mean 24-h plasma 18-OHB levels from 21. 9 +/-2. 0 to 14. 8 +/-1. 4 ng/dl.", "output": {"entities": {}}, "schema": []}
{"input": "Restarting time was not affected by magnesium cardioplegia.", "output": {"entities": {}}, "schema": []}
{"input": "The most common types of malformations were eye defects and open coeloms.", "output": {"entities": {}}, "schema": []}
{"input": "Repair of a cosmetic defect of the lower leg with a myocutaneous free flap.", "output": {"entities": {}}, "schema": []}
{"input": "According to the literature, second malignant epithelial tumours are, in contrast to mesenchymal tumours such as osteosarcoma, very rare in retinoblastoma survivors.", "output": {"entities": {}}, "schema": []}
{"input": "In Malmo, Sweden, 17, 181 school children born in the years 1961-1965 were screened for scoliosis once a year between the ages of 7 and 16 years, during 1971-1980.", "output": {"entities": {}}, "schema": []}
{"input": "Intra-articular dislocation of the patella.", "output": {"entities": {}}, "schema": []}
{"input": "This study demonstrates secretion of bicarbonate by the human stomach in vivo at a rate equivalent to 10--20% of basal acid secretion.", "output": {"entities": {}}, "schema": []}
{"input": "Histological evaluation revealed a more than twofold increase in the number of interepithelial mononuclear cells (p less than 0. 005), while the number of epithelial cells/100 microns of villous mucosa and the mean height of the epithelial cells were comparable in both groups.", "output": {"entities": {}}, "schema": []}
{"input": "Cramps in extrapyramidal disorders.", "output": {"entities": {}}, "schema": []}
{"input": "A suspected new storage disease in cattle.", "output": {"entities": {}}, "schema": []}
{"input": "For various dog vessels in vivo, Q/Dk ranged from 0. 15 to 47 X 10 (5) Torr/cm2.", "output": {"entities": {}}, "schema": []}
{"input": "The tetraphasic action of lidocaine on CNS electrical activity and behavior in cats.", "output": {"entities": {}}, "schema": []}
{"input": "Asymptomatic bacteriospermia and fertility", "output": {"entities": {}}, "schema": []}
{"input": "Triumph of Leninist national policy", "output": {"entities": {}}, "schema": []}
{"input": "The favourable effect of thymic shielding was also reflected in a significant increase of LD50/30, and the dose reduction factor was equal to 2.", "output": {"entities": {}}, "schema": []}
{"input": "The application of ultrafiltration to sample preparation in the detection and quantification of ethylene glycol in plasma by gas chromatography is described.", "output": {"entities": {}}, "schema": []}
{"input": "Mastocytosis.", "output": {"entities": {}}, "schema": []}
{"input": "A new Onchocerca species, a parasite of domestic cattle, in Senegal", "output": {"entities": {}}, "schema": []}
{"input": "It was suggested that the absence of pronounced differences between conditions may have been due to the complexity of the task or the type of prompts employed.", "output": {"entities": {}}, "schema": []}
{"input": "A limiting factor were disturbances in the system of energy transport (creatine phosphate, creatine phosphokinase) and of the calcium pump (Ca + +-ATPase of the sarcoplasmic reticulum, SPR), which evidently led to a decrease of the inotropic properties of the myocardium at 70% restriction of coronary blood flow.", "output": {"entities": {"gene": [{"text": "creatine phosphokinase", "start": 91, "end": 113}, {"text": "Ca + +-ATPase", "start": 140, "end": 153}]}}, "schema": []}
{"input": "Serum creatine kinase (SCK) was measured in ten subjects in the laboratory before and after the performance of bicycle ergometry and a lifting task.", "output": {"entities": {"gene": [{"text": "Serum creatine kinase", "start": 0, "end": 21}, {"text": "SCK", "start": 23, "end": 26}]}}, "schema": []}
{"input": "Organisms were not observed in the 5 bobcats trapped in 2 other counties.", "output": {"entities": {}}, "schema": []}
{"input": "The cause of death is often quite apparent from the pathological and toxicological findings; however, the manner of death often gives the examining official some difficulty.", "output": {"entities": {}}, "schema": []}
{"input": "The average annual cost per head of population was US + 0 X 46.", "output": {"entities": {}}, "schema": []}
{"input": "It is postulated that altered blood flow, mediated through the well-known prostaglandin synthetase inhibitory effects of ibuprofen, resulted in tubular necrosis.", "output": {"entities": {"gene": [{"text": "prostaglandin synthetase", "start": 74, "end": 98}]}}, "schema": []}
{"input": "Either 20 mg mitomycin/20 ml distilled water or 40 mg/40 ml distilled water was locally instilled into the bladder with a catheter after emptying it and was left for about 25-l20 min.", "output": {"entities": {}}, "schema": []}
{"input": "Both groups rejected pops with added SOA, decreasing mouthing times as SOA concentration increased.", "output": {"entities": {}}, "schema": []}
{"input": "The mean extracted concentration of flucloxacillin obtained at operation was 12. 9 micrograms/ml (SD 5. 25) in synovial fluid; 2. 9 micrograms/g (SD 3. 59) in synovium; 2. 0 micrograms/g (SD 1. 48) in cancellous bone and 1. 3 micrograms/g (SD 1. 25) in cortical bone.", "output": {"entities": {}}, "schema": []}
{"input": "A preliminary study of vincristine, methotrexate, and prednisolone (VM * P) combination chemotherapy for advanced adult non-Hodgkin' s lymphoma", "output": {"entities": {}}, "schema": []}
{"input": "Lacrimal secretion in hyperthyroidism", "output": {"entities": {}}, "schema": []}
{"input": "Re-examination of the ED01 study.", "output": {"entities": {}}, "schema": []}
{"input": "Based on 213 determinations, the control mean serum CPK activity was 262 +/-113 I. U./liter.", "output": {"entities": {"gene": [{"text": "serum CPK", "start": 46, "end": 55}]}}, "schema": []}
{"input": "A further study on plasminogen activator release by vasoactive agents in the isolated perfused dog leg.", "output": {"entities": {"gene": [{"text": "plasminogen activator", "start": 19, "end": 40}]}}, "schema": []}
{"input": "CDDP is active as a single agent in non-Hodgkin' s lymphoma.", "output": {"entities": {}}, "schema": []}
{"input": "Treatment of meat muscle 800 V for 45 s reduced weeping but increased slightly the rate of autoxidation of lipids.", "output": {"entities": {}}, "schema": []}
{"input": "A method for determining cumulative behavioral toxicity after chronic oral administration of l-alpha-acetylmethadol to female rats.", "output": {"entities": {}}, "schema": []}
{"input": "After successful subtotal parathyroidectomy, evident by the decrease of serum iPTH levels, both the CL of group 2 PMNs and the ability of group 2 sera to induce augmented CL in normal PMNs decreased (p < 0. 025).", "output": {"entities": {"gene": [{"text": "iPTH", "start": 78, "end": 82}]}}, "schema": []}
{"input": "TCZ provides quick, inexpensive, noninvasive indication of tissue necrosis, moderate-to-severe intracranial hemorrhage, and delayed brain maturation.", "output": {"entities": {}}, "schema": []}
{"input": "The number of muricidal rats increased with increase in the duration of Cd administration in association with greater accumulation of Cd in the olfactory bulb than in any other region of the brain.", "output": {"entities": {}}, "schema": []}
{"input": "This test should provide another practical means to study leprosy.", "output": {"entities": {}}, "schema": []}
{"input": "The preferences were for intact vis-a-vis castrated males, though injections of TP restored the castrates' attractiveness to the females.", "output": {"entities": {}}, "schema": []}
{"input": "Each trial consisted of light and buzzer for five seconds as conditioned stimuli and electric shock for five seconds as an unconditioned stimulus.", "output": {"entities": {}}, "schema": []}
{"input": "Family visits and involvement in treatment of patients at a state hospital.", "output": {"entities": {}}, "schema": []}
{"input": "A transparent overlay for assessing amplitude of ECG wave forms.", "output": {"entities": {}}, "schema": []}
{"input": "Adverse reaction of the apparently healthy partner in response to improvement in the overtly dysfunctional partner.", "output": {"entities": {}}, "schema": []}
{"input": "Brain scan with 99mTc-labelled macroaggregated albumin (MAA brain scan) and computed tomography studies (CT) were performed on 78 patients with intracranial diseases.", "output": {"entities": {"gene": [{"text": "macroaggregated albumin", "start": 31, "end": 54}, {"text": "MAA", "start": 56, "end": 59}]}}, "schema": []}
{"input": "Inhibition of Fusarium moniliforme var. subglutinans, the causal agent of pine pitch canker, by the soil bacterium Arthrobacter sp.", "output": {"entities": {}}, "schema": []}
{"input": "The five-drug combination of fluorouracil imidazole carboxamide dimethyl triazeno, vincristine, bis-chloroethyl nitrosourea, and prednisone (FIVB + P) was given to 120 women with metastatic breast cancer.", "output": {"entities": {}}, "schema": []}
{"input": "A method is described for the simultaneous determination of 1, alpha-acetylmethadol (LAAM) and five active metabolites--noracetylmethadol, dinoracetylmethadol, methadol, normethadol, and dinormethadol--in biofluids by high-performance liquid chromatography using a normal-phase column and a UV detector at 218 nm.", "output": {"entities": {}}, "schema": []}
{"input": "Clinical and anatomical considerations", "output": {"entities": {}}, "schema": []}
{"input": "Theory and applications of pulse dosing: a summary of the symposium.", "output": {"entities": {}}, "schema": []}
{"input": "These results show that the neonate differs from the adult in respect of both the nature of effects of the drug and sensitivity to it.", "output": {"entities": {}}, "schema": []}
{"input": "To evaluate the gas chromatographic electron capture detection method described earlier, 23 plasma samples have been analysed by both techniques.", "output": {"entities": {}}, "schema": []}
{"input": "The hemodynamics of isoproterenol-induced cardiac failure in the rat.", "output": {"entities": {}}, "schema": []}
{"input": "Several authors have recently reported interference in theophylline analysis by paraxanthine (1, 7-dimethylxanthine), an important metabolite of caffeine.", "output": {"entities": {}}, "schema": []}
{"input": "Multi drug regimens like C-MOPP, CHOP and BACOP led to high remission rates and in some cases probably also to a cure of the disease.", "output": {"entities": {}}, "schema": []}
{"input": "Morphological features of Jat dentition.", "output": {"entities": {}}, "schema": []}
{"input": "Clinical accuracy of updated version of the Phadebas RAST test.", "output": {"entities": {}}, "schema": []}
{"input": "Five control subjects with COPD, who performed the same sequence of tests without breathing 30% O2, showed no change in flow rates or density dependence.", "output": {"entities": {}}, "schema": []}
{"input": "Following extended recovery hippocampal EEG was normal despite extensive cellular loss in areas CA3 and CA4.", "output": {"entities": {}}, "schema": []}
{"input": "Cross reactivity in theophylline RIA kit decreased.", "output": {"entities": {}}, "schema": []}
{"input": "Strontium-90 was inject i. v. into pregnant rats on day 18 post conception (p. c.).", "output": {"entities": {}}, "schema": []}
{"input": "Recording of the digital sphygmic activity in the lower extremities with the photoplethysmographic and strain-gauge methods.", "output": {"entities": {}}, "schema": []}
{"input": "Eight hr of acidosis caused a significant (P less than 0. 01) decrease in P50 in vitro which fell from 29. 0 to 24. 4 torr.", "output": {"entities": {}}, "schema": []}
{"input": "Catheter transit slows the response to a step increase in concentration by about 0. 13 s (from 10 per cent-90 per cent) and prolongs the transit time through the catheter for a volatile anesthetic by about 0. 04 s more than N2.", "output": {"entities": {}}, "schema": []}
{"input": "These women should not be given the current estrogen PPI, which was designed to warn women of the risks of long-term estrogen use; a PPI should be written specifically for patients receiving short courses.", "output": {"entities": {}}, "schema": []}
{"input": "The oral temperature rose and the serum creatine kinase levels fell only in those patients who were actively warmed.", "output": {"entities": {"gene": [{"text": "serum creatine kinase", "start": 34, "end": 55}]}}, "schema": []}
{"input": "Determination of aortic distensibility and its variations in arterial hypertension.", "output": {"entities": {}}, "schema": []}
{"input": "We studied the role of prostaglandins in acid-induced esophagitis and the associated LES hypotension by simultaneous treatment of some animals with indomethacin (150 micrograms/kg intravenous), a specific inhibitor of prostaglandin synthesis, either during production of esophagitis or during recovery.", "output": {"entities": {}}, "schema": []}
{"input": "Since only 58% of our sample could be adequately classified with one diagnosis, we expect that the ASDC nosology will need to evolve further.", "output": {"entities": {}}, "schema": []}
{"input": "A surgical technique for correcting this problem is described.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of prostaglandin inhibitors on the onset of proteinuria and stroke in stroke-prone spontaneously hypertensive rats.", "output": {"entities": {}}, "schema": []}
{"input": "In this study, the general clinical criteria for inhalation injury--presence of facial or oropharyngeal burns, carboxyhemoglobin levels, carbonaceous sputum, or closed space injury--did not differentiate patients with airway injury only from those with parenchymal injury.", "output": {"entities": {"gene": [{"text": "carboxyhemoglobin", "start": 111, "end": 128}]}}, "schema": []}
{"input": "Methisergide (0. 5 mg/kg, i. p.), a blocker of serotonin receptors, prevented the development of the antinociceptive effect of serotonin.", "output": {"entities": {"gene": [{"text": "serotonin receptors", "start": 47, "end": 66}]}}, "schema": []}
{"input": "The plasma half-life of slow disposition phase t1/2 beta, increases from 0. 26 hour in rabbits with normal renal function to 5. 41 hours in rabbits with severe renal impairment.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of early monocular deprivation on development of cortico-geniculate projections in the cat.", "output": {"entities": {}}, "schema": []}
{"input": "Corticosteroid therapy is known to be hazardous in patients with occult infection but the mechanism by which the host parasite relationship is altered by steroids is not known. We have used an intestinal protozoal parasite, Giardia muris, to examine the effects of corticosteroids on the number of parasites in the intestine in the course of a primary infection.", "output": {"entities": {}}, "schema": []}
{"input": "Static lung function in puppies after pneumonectomy.", "output": {"entities": {}}, "schema": []}
{"input": "Bilateral Charnley arthroplasty as a single procedure.", "output": {"entities": {}}, "schema": []}
{"input": "The relationship between estrogenic properties of Tamoxifen and breast cancer management is discussed.", "output": {"entities": {}}, "schema": []}
{"input": "A fluoroimmunoassay for the determination of serum of plasma levels of propranolol was developed using antibodies to propranolol coupled to magnetizable solid-phase particles and fluorescein-labeled propranolol as tracer.", "output": {"entities": {}}, "schema": []}
{"input": "The syncytial microvillous projections seemed to be more numerous and longer in CNF, otherwise the structure of the trophoblastic layer of the villi and the lining of the subtrophoblastic vessels were identical in CNF and controls.", "output": {"entities": {}}, "schema": []}
{"input": "When pollen allergen from three grass species were used, The RAST-test results did not differ from duplicate values either.", "output": {"entities": {}}, "schema": []}
{"input": "DMI and 2-OH-DMI concentrations were determined in a similar group of 61 DMI-treated patients.", "output": {"entities": {}}, "schema": []}
{"input": "It has been shown in experiments in vitro that the hepatotrophic organic anions, the radiographic contrast agent (RCA) bilignost used in cholecystography and Bengal pink, have an affinity, unlike the urographic RCA triombrin and renotrophic dye indigo-carmine, for the plasmatic membranes (PM) of liver cells.", "output": {"entities": {}}, "schema": []}
{"input": "33 out of 90 neurons of the cat medial geniculate body revealed the selectivity of their afterdischarges to movement of sound when velocity of the movement changed from 30 to 180 deg/s.", "output": {"entities": {}}, "schema": []}
{"input": "In controls, only modest differences were observed.", "output": {"entities": {}}, "schema": []}
{"input": "Assay of serum immunoreactive trypsin in dried blood spots and the early detection of cystic fibrosis.", "output": {"entities": {"gene": [{"text": "serum immunoreactive trypsin", "start": 9, "end": 37}]}}, "schema": []}
{"input": "Similar waves were seen on cross-correlating a motor unit with an electronic oscillator, confirming that their occurrence does not necessarily demonstrate the existence of active neural interactions.", "output": {"entities": {}}, "schema": []}
{"input": "Leukocyte enzyme activity and blood lymphocyte blast transformation in chronic bronchitis", "output": {"entities": {}}, "schema": []}
{"input": "In literature, the HBE has been displayed by application of the averaging method.", "output": {"entities": {}}, "schema": []}
{"input": "Forty-five cases were surgically by direct approach to the tumour, while two cases were treated only with a shunt.", "output": {"entities": {}}, "schema": []}
{"input": "In Group V, the salvaged tissue was primarily subepicardial with virtually no lateral zone of salvaged tissue (ratio of salvaged subepicardium to salvaged subendocardium 14. 8 +/-1. 9 to 1).", "output": {"entities": {}}, "schema": []}
{"input": "Progressive 100-mmHg stepwise decreases in superfusate oxygen partial pressure (PO2) from control (95% O2 aeration, PO2, 620-650 mmHg) were produced, and subsequent changes in isometric active and resting tension were measured.", "output": {"entities": {}}, "schema": []}
{"input": "The known B1-deficiency reaches excessive high values with light exercise.", "output": {"entities": {}}, "schema": []}
{"input": "Based on AUC infinity analyses, the pharmacokinetics of buflomedil were found to be linear within the dose ranges studied (50 to 200 mg for i. v. injection and 150 to 450 mg for oral administration).", "output": {"entities": {}}, "schema": []}
{"input": "Gastrin secretion during food stimulation in digestive system diseases", "output": {"entities": {"gene": [{"text": "Gastrin", "start": 0, "end": 7}]}}, "schema": []}
{"input": "Fibrinogen determination using the KZM-1 meter", "output": {"entities": {"gene": [{"text": "Fibrinogen", "start": 0, "end": 10}]}}, "schema": []}
{"input": "Delayed or paradoxically emptying regions of the left ventricle were detected by a relatively new nuclear technique--phase imaging.", "output": {"entities": {}}, "schema": []}
{"input": "Responses to brainstem of nuclei medialis dorsalis, lateralis posterior were of considerably longer latency.", "output": {"entities": {}}, "schema": []}
{"input": "Nineteen patients with non-visualized gallbladder with OCG subsequently had Tc-99m-PyG cholescintigraphy performed.", "output": {"entities": {}}, "schema": []}
{"input": "One was allowed fresh drinking water ad libitum whilst the other received Aludrox in their drinking water.", "output": {"entities": {}}, "schema": []}
{"input": "Anamnestic data were obtained from case history, smoking habits were not known in collective A and C.", "output": {"entities": {}}, "schema": []}
{"input": "The determination of physical performance capacity was based on W170, W85% and on predicted VO2 max measured with continuously increasing work load on a bicycle ergometer.", "output": {"entities": {}}, "schema": []}
{"input": "Determination of lead in blood.", "output": {"entities": {}}, "schema": []}
{"input": "Effect of indomethacin and prostaglandin F2 alpha on parturition in swine.", "output": {"entities": {}}, "schema": []}
{"input": "LD50 values of terms of KP were 84 mg/kg in male rats and 122 mg/kg in female rats when KP-CMC was administered intrarectally, and 117 mg/kg in male and 92 mg/kg in female when KP-T10 was administered intrarectally., while peroral administration of KP-CMC showed LD50 values of 68 mg/kg in males and 78 mg/kg in females in terms of KP.", "output": {"entities": {}}, "schema": []}
{"input": "Autotransfusion was performed as follows: Heparin-ACD-B-Heparin-DPD-Heparin-ACD-B etc.", "output": {"entities": {}}, "schema": []}
{"input": "Generally the differences between short gut and sham operation animals disappeared when the data were normalised for mucosal weight.", "output": {"entities": {}}, "schema": []}
{"input": "A simplified thin-layer chromatographic determination of hippuric acid and methylhippuric acids.", "output": {"entities": {}}, "schema": []}
{"input": "The architecture of microvasculature in these two regions was also examined by scanning electron microscopy, using the resin casting method.", "output": {"entities": {}}, "schema": []}
{"input": "MSMS Council hears new public health director.", "output": {"entities": {}}, "schema": []}
{"input": "Chordoma of the spinal cord in a F344 rat.", "output": {"entities": {}}, "schema": []}
{"input": "Micro high-performance liquid chromatographic system with micro precolumn and dual electrochemical detector for direct injection analysis of catecholamines in body fluids.", "output": {"entities": {}}, "schema": []}
{"input": "A narrow zone of myelin-axonal dissociation was also observed.", "output": {"entities": {}}, "schema": []}
{"input": "The IgA deficiency is combined with the IgE one.", "output": {"entities": {"gene": [{"text": "IgA", "start": 4, "end": 7}, {"text": "IgE", "start": 40, "end": 43}]}}, "schema": []}
{"input": "In PB mice, there was only a small deficit in the number of the hippocampal pyramidal neurons compared to controls (15%, p less than 0. 01), and no deficit in the granule cells.", "output": {"entities": {}}, "schema": []}
{"input": "Nutritional cataracts in timber wolves.", "output": {"entities": {}}, "schema": []}
{"input": "The quantitative determination of HBSAG--a valuable aid in evaluating the infectiousness of hepatitis B virus carriers", "output": {"entities": {"gene": [{"text": "HBSAG", "start": 34, "end": 39}]}}, "schema": []}
{"input": "2. numerous narrow shunt vessels departing continuously from the primary arteries to feed a secondary arterial system which parallels the primary one.", "output": {"entities": {}}, "schema": []}
{"input": "Urological complications are frequent during and after the treatment of gynecological malignancy.", "output": {"entities": {}}, "schema": []}
{"input": "Arachnoid cyst.", "output": {"entities": {}}, "schema": []}
{"input": "Hypotension was produced by head up tilt.", "output": {"entities": {}}, "schema": []}
{"input": "Therefore the procedure of Lich-Gregoir is not to be recommended in adults.", "output": {"entities": {}}, "schema": []}
{"input": "Mucoepidermoid and acinous cell carcinomas of salivary tissues.", "output": {"entities": {}}, "schema": []}
{"input": "Twenty patients aged 45 or older with the diagnosis of endogenous depression were evaluated in terms of safety and efficacy in their response to multiple monitored electroconvulsive therapy (MMECT) versus single electroconvulsive therapy (SECT).", "output": {"entities": {}}, "schema": []}
{"input": "Longitudinal force-length relationships of guinea pig ureter were studied in vitro in animals 3 weeks, 3 months, and 3 years of age.", "output": {"entities": {}}, "schema": []}
{"input": "Tests of the method indicate (1) the Mossbauer source can be placed on the basilar membrane without altering the signal-transmission properties of the cochlea, and (2) the source adheres to the basilar membrane.", "output": {"entities": {}}, "schema": []}
{"input": "Angiographic work-up in a patient with late vaginal metastasis from a renal carcinoma.", "output": {"entities": {}}, "schema": []}
{"input": "The authors conclude that nonspecificity of low platelet MAO as a possible correlate of bipolar affective disorder, as well as schizophrenia, increases the burden of proof necessary before findings of low platelet MAO can be accepted as primary.", "output": {"entities": {"gene": [{"text": "platelet MAO", "start": 48, "end": 60}, {"text": "platelet MAO", "start": 205, "end": 217}]}}, "schema": []}
{"input": "Ecthyma, a known disease, of which little is known", "output": {"entities": {}}, "schema": []}
{"input": "Estrogen replacement, either as 17 beta-estradiol or beta-estradiol-3-benzoate via subcutaneous Silastic capsules, was associated with elevated rates of heat production and dry heat loss relative to untreated ovariectomized controls.", "output": {"entities": {}}, "schema": []}
{"input": "The following aspects were assessed: (1) The effect on the cardiovascular system in terms of brachial arterial pressure, pulse rate, and oxygen consumption (VO2) during exercise in 5 health volunteers; (2) emg activity of the tibialis anterior and gastrocnemius muscles during exercise in the same 5 volunteers; and (3) postexercise ankle pressure changes in 10 subjects with angiographically proven occlusive arterial diseases of the lower extremities.", "output": {"entities": {}}, "schema": []}
{"input": "It was argued that this arose from the possibility that the nature of blue collar jobs was physical, and that loss of myocardial tissue might be expected to more markedly interfere with their work efficiency (on returning to work) than it would the efficiency of the more sedentary jobs of white collar workers.", "output": {"entities": {}}, "schema": []}
{"input": "Importance of determining the blood sulfhydryl groups in fractures of the long tubular bones complicated by infection", "output": {"entities": {}}, "schema": []}
{"input": "The results revealed increased blood lead level associated with decreased blood haemoglobin and increased urinary excretion of delta amino levulinic acid.", "output": {"entities": {"gene": [{"text": "blood haemoglobin", "start": 74, "end": 91}]}}, "schema": []}
{"input": "Following iv injection of 0. 5 g galactose per kg body weight, together with 2 mu Ci generally 14C-labelled galactose, 14CO2 is collected in regular intervals during one hour.", "output": {"entities": {}}, "schema": []}
{"input": "Specific clotting factor assays showed an isolated deficiency of factor X ranging from 7 to 12 per cent on three determinations.", "output": {"entities": {"gene": [{"text": "factor X", "start": 65, "end": 73}]}}, "schema": []}
{"input": "Blood variables measured at eight intervals before, during, and after operation were as follows: seven plasma proteins, free hemoglobin, formed elements, and clotting functions.", "output": {"entities": {"gene": [{"text": "hemoglobin", "start": 125, "end": 135}]}}, "schema": []}
{"input": "The ability of sodium phenobarbital (60 mg/kg) and sodium barbital (80 mg/kg) to produce a taste aversion in 23 hr fluid deprived rats was examined using a discrimination or two bottle taste aversion task (0. 125% sodium saccharin solution or water).", "output": {"entities": {}}, "schema": []}
{"input": "It appears that the pulmonary gas exchange parenchyma of these smallest mammals is well suited to supply the organism with the comparatively high levels of O2 required by the high metabolic rates, exhibiting a structural adaptation of the lung to higher VO2.", "output": {"entities": {}}, "schema": []}
{"input": "Underestimations by as much as 35% may occur due to the problems in the existing methodologies.", "output": {"entities": {}}, "schema": []}
{"input": "Chemotherapy was administered without altering the course of the disorder.", "output": {"entities": {}}, "schema": []}
{"input": "Drug inhibition of whole blood aspirin esterase.", "output": {"entities": {"gene": [{"text": "aspirin esterase", "start": 31, "end": 47}]}}, "schema": []}
{"input": "However, at lower temperature the positive staircase was not clear and rather negative staircase appeared (1--3 Hz).", "output": {"entities": {}}, "schema": []}
{"input": "Visual averaged evoked responses and platelet monoamine oxidase in patients suffering from alcoholism.", "output": {"entities": {"gene": [{"text": "platelet monoamine oxidase", "start": 37, "end": 63}]}}, "schema": []}
{"input": "At the end of the experiment the urinary porphyrin excretion and the porphyrin content in lijver and skin were diminished in HCB-CQ-treated animals by about 50% compared to the HCB controls.", "output": {"entities": {}}, "schema": []}
{"input": "Although stone-formers were not found to display any features of magnesium metabolism that were different from those in the control group, their lower urinary excretion of magnesium in relation to calcium may be a factor in their increased stone-forming propensity.", "output": {"entities": {}}, "schema": []}
{"input": "A 16-year follow-up study of 69 paraplegics with complete lesions from T1-L3 is presented.", "output": {"entities": {}}, "schema": []}
{"input": "Hippocampal stimulation overlapping conditioned stimulus preexposure produced attenuation of latent inhibition, as did stimulation presented during conditioning after preexposure.", "output": {"entities": {}}, "schema": []}
{"input": "The centromedial amygdala and gastric pathology in rats.", "output": {"entities": {}}, "schema": []}
{"input": "Cataract extraction in primary glaucoma", "output": {"entities": {}}, "schema": []}
{"input": "Number and size of the myelin structures in the pneumocytes typ II increased simultaneously.", "output": {"entities": {}}, "schema": []}
{"input": "In the intact animal, postextrasystolic potentiation depended on the basic pacing interval, t0, and the timing of the extrasystole, t1: when t0 was held constant and t1 was increased, potentiation decreased; when t1 was held constant and t0 was increased, potentiation increased.", "output": {"entities": {}}, "schema": []}
{"input": "In spite of this and other complications of corticosteroids, she made a full recovery from the fungal infection following treatment with amphotericin B and surgical excision of the lung abscess.", "output": {"entities": {}}, "schema": []}
{"input": "Implications of this observation for pediatrics are discussed.", "output": {"entities": {}}, "schema": []}
{"input": "For the study of the transition of long to short waves (deep-water waves) a closed-form solution is advantageous; this can, however, only be obtained at the cost of further simplification.", "output": {"entities": {}}, "schema": []}
{"input": "Treatment of suppurative peritonitis", "output": {"entities": {}}, "schema": []}
{"input": "We report a case of pheochromocytoma manifesting during the third trimester of pregnancy.", "output": {"entities": {}}, "schema": []}
{"input": "Fasting plasma and lipoprotein lipid concentrations, adipose tissue lipoprotein lipase activity, anthropometric data, alcohol consumption, smoking habits, weekly mileage run and performance on a bicycle ergometer were recorded before and after the training period.", "output": {"entities": {"gene": [{"text": "adipose tissue lipoprotein lipase", "start": 53, "end": 86}]}}, "schema": []}
{"input": "The C18: 1: C10 value is a convenient measure of these changes and can be determined more rapidly than determining all the lower fatty acids.", "output": {"entities": {}}, "schema": []}
{"input": "A progressive growth of blood erythrocyte membrane injury has been demonstrated after rats were exposed to gamma-irradiaton at a dose of 100 to 500 Gy.", "output": {"entities": {}}, "schema": []}
{"input": "Within the 3' terminal 50 nucleotides, the mouse mt 12S rRNA contains a potential 10 bp hairpin structure and a sequence of 15 consecutive nucleotides common to the RNA of the small ribosomal subunit in all systems, but does not contain the mRNA binding site (ACCUCC) found in E. coli and corn chloroplast rRNAs.", "output": {"entities": {"gene": [{"text": "mouse mt 12S rRNA", "start": 43, "end": 60}]}}, "schema": []}
{"input": "Thirty cadaver brains were examined under X 6 to 16 magnification in order to define the microsurgical anatomy of the pineal region, particularly the relationship of the pineal body, posterior cerebral artery, superior cerebellar artery, vein of Galen, basal vein of Rosenthal, internal cerebral vein, straight sinus, bridging vein, the size of the tentorial notch, and the third and the fourth cranial nerves.", "output": {"entities": {}}, "schema": []}
{"input": "Serum antibody titre was not significantly associated with the recurrence rate or the duration of infection.", "output": {"entities": {}}, "schema": []}
{"input": "We propose that refeeding may be an important mechanism for activation of certain viral infections previously suppressed by famine.", "output": {"entities": {}}, "schema": []}
{"input": "One hundred twenty units of deglycerolized red blood cells, some with glycerol added so as to exceed an acceptable 1% glycerol content, had measurements made of the post-wash supernatant fluid by refractive index and osmometry.", "output": {"entities": {}}, "schema": []}
{"input": "The symptoms and objective findings were caused by a malignant lymphoma, and the diagnosis was established from a drill biopsy.", "output": {"entities": {}}, "schema": []}
{"input": "Our study differs from previous studies in that it is limited to one diagnostic entity, yet at the same time evaluates a broad range of social and work-related factors in disability.", "output": {"entities": {}}, "schema": []}
{"input": "It is suggested that a raised hydroxykynurenine/hydroxyanthranilic acid ratio does not necessarily indicate vitamin B6 deficiency but may represent a nonspecific response of tryptophan metabolism to stress.", "output": {"entities": {}}, "schema": []}
{"input": "All control persons had a normal reaction to DNFB.", "output": {"entities": {}}, "schema": []}
{"input": "In a control group both common carotid arteries (CCA) were ligated.", "output": {"entities": {}}, "schema": []}
{"input": "At pH 6. 9, the same lidocaine concentrations significantly reduced resting potential (3-10%), action potential amplitude (3-8%) and Vmax (14-22%).", "output": {"entities": {}}, "schema": []}
{"input": "Simultaneous right and left adrenal and peripheral blood samples were collected for determination of oestrone (E1) and oestradiol (E2).", "output": {"entities": {}}, "schema": []}
{"input": "Arm function tests.", "output": {"entities": {}}, "schema": []}
{"input": "All lambs with B breeding had significantly higher Hb levels at the end of the experiment than did NB lambs. b and S x B lambs had higher (P <. 05) Hb levels than the D x B lambs, and B lambs had the highest (P <. 05) mean corpuscular hemoglobin concentrations.", "output": {"entities": {"gene": [{"text": "Hb", "start": 51, "end": 53}, {"text": "Hb", "start": 148, "end": 150}, {"text": "hemoglobin", "start": 235, "end": 245}]}}, "schema": []}
{"input": "The same response occurs whether acrylamide is given immediately after nerve ligation or 1 week later.", "output": {"entities": {}}, "schema": []}
{"input": "The operation recommended is excision of 3 mm of central slip followed by end-to-end repair of the tendon.", "output": {"entities": {}}, "schema": []}
{"input": "In the unclipped group arterial pressure decreased 50 mmHg to normal by 24 h and was associated with increased diuresis and a small decrease in blood volume (9. 8%).", "output": {"entities": {}}, "schema": []}
{"input": "Marked sedative activity was observed with 9-methoxy-5-phenylpyrrolo [2, 1-d] [1, 5] benzothiazepin-6, 6-dioxide (NF19) and 9-chloro-5-p-nitrophenylpyrrolo [2, 1-d] [1, 5] benzothiazepin-6, 6-dioxide (NF20).", "output": {"entities": {}}, "schema": []}
{"input": "In patients, the effect of CCK-PZ on the movement of the terminal part of the bile duct was measured with a pressure sensor using a duodenofiberscope.", "output": {"entities": {"gene": [{"text": "CCK", "start": 27, "end": 30}, {"text": "PZ", "start": 31, "end": 33}]}}, "schema": []}
{"input": "As high-speed, volumetric imaging, computed tomographic scan machines such as the Dynamic Spatial Reconstructor become available with higher density resolution, perhaps a single injection of contrast agent into the right atrium or even a peripheral vein may be adequate to obtain all these measurements.", "output": {"entities": {}}, "schema": []}
{"input": "The ESEG' s are a direct result of the NEXT study.", "output": {"entities": {}}, "schema": []}
{"input": "The potentially SLE-inducing drugs are reviewed.", "output": {"entities": {}}, "schema": []}
{"input": "A third series of mice were given a single injection of 5-OH-DA, sacrificed, and prepared for ultrastructural study.", "output": {"entities": {}}, "schema": []}
{"input": "Fourteen different species (eight Platyhelmintha, one Nematoda and five Crustacea) have been inventorized.", "output": {"entities": {}}, "schema": []}
{"input": "No symptoms other than hot flush showed such significant correlation with plasma epinephrine or norepinephrine levels.", "output": {"entities": {}}, "schema": []}
{"input": "The mean values of the concentrations of the components due to tobacco smoke are: CO = 1. 1 ppm, NO = 32 ppb, NO2 = 24 ppb, nicotine = 0. 9 micrograms/m3, particulate matter = 133 micrograms/m3.", "output": {"entities": {}}, "schema": []}
{"input": "The average backscatter coefficient was six time larger in regions of infarct studied 8--10 weeks after occlusion than that in regions of infarct studied 5--6 weeks after occlusion.", "output": {"entities": {}}, "schema": []}
{"input": "At 4 wk however, tumor relapse was noted in 6 of 7 group 4 responders, 10 of 12 in group 5, 13 of 16 in group 7, but only 4 of 19 group 8 responders (p less than. 001 group 8 versus 4, 5, 7).", "output": {"entities": {}}, "schema": []}
{"input": "Early infection was detected in one of 50 control women who gave birth to a healthy infant.", "output": {"entities": {}}, "schema": []}
{"input": "Pentachlorophenol accelerates the onset of HCB porphyria, in other words it increases the total urinary porphyrin excretion and causes an earlier disturbance of the porphyrin pattern.", "output": {"entities": {}}, "schema": []}
{"input": "Family planning continues to play a minor role, and only 25. 3 per cent of all patients reviewed took to oral contraceptives for shorter or longer periods of time.-The percentages of primiparae and secundiparae in all births as well as the high percentage of multigravidity are parameters by which the approach to reproduction differs substantively from behaviour patterns in Europe.", "output": {"entities": {}}, "schema": []}
{"input": "The term osteomesopycnosis is proposed for a sclerosing bone disease with dominant inheritance that has been discovered in five members of four different families.", "output": {"entities": {}}, "schema": []}
{"input": "The 87K protein, together with proteins of 105, 000 and 75, 000 daltons, are translated from leftward transcribed (1-strand) messenger RNAs that are complementary to the viral genome between positions 11. 2 and 31. 5.", "output": {"entities": {}}, "schema": []}
{"input": "The identification of viable myocardium with both 99mTc-tetrofosmin and 201Tl can be greatly enhanced to a similar degree if the severity of reduction in activity within nonreversible defects is considered.", "output": {"entities": {}}, "schema": []}
{"input": "The temporal component lacked a mandibular fossa as well as articular eminence.", "output": {"entities": {}}, "schema": []}
{"input": "EUK-8 is a novel, synthetic, low-molecular-weight salen-manganese complex that exhibits both superoxide dismutase and catalase activities in vitro.", "output": {"entities": {"gene": [{"text": "superoxide dismutase", "start": 93, "end": 113}, {"text": "catalase", "start": 118, "end": 126}]}}, "schema": []}
{"input": "The protein ELT-1, encoded by a single-copy gene homologous to the GATA family of vertebrate transcription factors, is potentially capable of interacting with this element.", "output": {"entities": {"gene": [{"text": "protein ELT-1", "start": 4, "end": 17}, {"text": "GATA family of vertebrate transcription factors", "start": 67, "end": 114}]}}, "schema": []}
{"input": "However, in contrast with previous in vitro cell-free integration studies, alteration of the highly conserved CA dinucleotide resulted in a mutant which still retained 40% of wild-type integration activity.", "output": {"entities": {}}, "schema": []}
{"input": "These results demonstrate that although PI2 and PI3 viruses belong to the same parainfluenza virus genus, these viruses show marked differences with respect to functional requirements for the cytoplasmic tail of the F glycoprotein.", "output": {"entities": {"gene": [{"text": "F glycoprotein", "start": 216, "end": 230}]}}, "schema": []}
{"input": "By site-specific mutagenesis, we also show that individual ICP27 C-terminal amino acid residues that are positionally conserved in ICP27 homologs in other herpesviruses (D-357, E-358, H-479, C-400, C-483, and C-488) are critical for trans-regulatory activity.", "output": {"entities": {"gene": [{"text": "ICP27 C-terminal amino acid residues", "start": 59, "end": 95}, {"text": "ICP27 homologs", "start": 131, "end": 145}]}}, "schema": []}
{"input": "Magnetic resonance imaging (MRI) has enabled us to see the spinal intramedullary pathology as differences in signal intensity.", "output": {"entities": {}}, "schema": []}
{"input": "Patients with psychotropic drugs showed significantly higher PRL levels.", "output": {"entities": {"gene": [{"text": "PRL", "start": 61, "end": 64}]}}, "schema": []}
{"input": "The Laser Scanning Ophthalmoscope enables a fundus-based examination and therefore allows exact comparison between morphologic appearance and corresponding function.", "output": {"entities": {}}, "schema": []}
{"input": "Malaria, anaemia, and HIV-1 transmission in central Africa.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, two-dimensional nuclear magnetic resonance studies with F17A, K13Q, F15Y and F27Y revealed that the mutants have the same overall structure as the wild-type CspB protein.", "output": {"entities": {"gene": [{"text": "wild-type CspB protein", "start": 160, "end": 182}]}}, "schema": []}
{"input": "Considerably high levels of IgE antibodies was also established while other pollens did not show such correspondence.", "output": {"entities": {"gene": [{"text": "IgE antibodies", "start": 28, "end": 42}]}}, "schema": []}
{"input": "This is particularly intriguing because SKUT-1B-20 cells lack the transcription factor Pit-1.", "output": {"entities": {"gene": [{"text": "Pit-1", "start": 87, "end": 92}]}}, "schema": []}
{"input": "Some strains of A. parasiticus produced all four aflatoxins B1 B2 G1 G2, while the other ones produced AF B1 + G1 only, with concentrations of aflatoxins from 0. 1 to 450 mg/kg.", "output": {"entities": {}}, "schema": []}
{"input": "We have isolated a new, larger rat B-myc genomic clone.", "output": {"entities": {"gene": [{"text": "rat B-myc genomic clone", "start": 31, "end": 54}]}}, "schema": []}
{"input": "In addition to the nine and 51 terminal amino acid forms already known, we identified a third with 43 terminal amino acids predicted to encode a novel RET protein isoform.", "output": {"entities": {"gene": [{"text": "RET protein isoform", "start": 151, "end": 170}]}}, "schema": []}
{"input": "Both classes of MHBst proteins were found to form dimers; an which is involved in mediating the dimerization.", "output": {"entities": {"gene": [{"text": "MHBst proteins", "start": 16, "end": 30}]}}, "schema": []}
{"input": "She had been receiving MTX 7. 5 mg/week for 2. 5 months because of her vasculitis symptoms.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of the sequence identified four open reading frames (ORFs) which are designated UL1, UL2, UL3, and UL3. 5 based on their homology with proteins of herpes simplex virus-1 (HSV-1), pseudorabies virus (PRV), equine herpesvirus-1, and varicella-zoster virus.", "output": {"entities": {"gene": [{"text": "UL1", "start": 89, "end": 92}, {"text": "UL2", "start": 94, "end": 97}, {"text": "UL3", "start": 99, "end": 102}, {"text": "UL3. 5", "start": 108, "end": 114}]}}, "schema": []}
{"input": "These HPV16 E6/E7 cDNAs were cloned under the SV40 enhancer/promoter and the MMTV LTR to examine the activities of ras-collaborative transformation and induction of cellular DNA synthesis, both of which depend on the E7 gene product.", "output": {"entities": {"gene": [{"text": "E6", "start": 12, "end": 14}, {"text": "E7", "start": 15, "end": 17}, {"text": "SV40 enhancer/promoter", "start": 46, "end": 68}, {"text": "MMTV LTR", "start": 77, "end": 85}, {"text": "ras", "start": 115, "end": 118}, {"text": "E7 gene", "start": 217, "end": 224}]}}, "schema": []}
{"input": "Correlation coefficients between the reference methods and NIT were > or = 0. 95 for water, fat, crude protein and connective-tissue-protein frei meat protein, and > or = 0. 86 for connective-tissue-protein.", "output": {"entities": {}}, "schema": []}
{"input": "The translation products of both clones are highly homologous to APS1 (66 and 86% identity, respectively) over their entire lengths, including amino terminal sequences resembling transit peptides for plastid localization.", "output": {"entities": {"gene": [{"text": "APS1", "start": 65, "end": 69}]}}, "schema": []}
{"input": "The serum levels of IgE, and asIgE and IgG-4 against 14 common food allergens were determined.", "output": {"entities": {"gene": [{"text": "IgE", "start": 20, "end": 23}, {"text": "asIgE", "start": 29, "end": 34}, {"text": "IgG-4", "start": 39, "end": 44}]}}, "schema": []}
{"input": "Two experiments investigating the effects of short-term spaceflight on cancellous bone turnover were carried out: Physiological Systems Experiment-1 (PSE-1) (a 4-d orbital spaceflight) and PSE-2 (a 10-d flight).", "output": {"entities": {}}, "schema": []}
{"input": "Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast two-hybrid system.", "output": {"entities": {"gene": [{"text": "aryl hydrocarbon receptor nuclear translocator", "start": 23, "end": 69}, {"text": "aryl hydrocarbon receptor", "start": 88, "end": 113}]}}, "schema": []}
{"input": "Histopathologic observations showed that both somatostatin and triamcinolone acetonide reduced the inflammatory signs in the joint structures, although triamcinolone acetonide appeared to be more effective.", "output": {"entities": {"gene": [{"text": "somatostatin", "start": 46, "end": 58}]}}, "schema": []}
{"input": "An approach to a biomathematical model of lymphocytopoiesis.", "output": {"entities": {}}, "schema": []}
{"input": "The influenza virus NS1 protein is a unique posttranscriptional regulator that has two activities: inhibition of the nuclear export of poly A-containing mRNAs and inhibition of pre-mRNA splicing.", "output": {"entities": {"gene": [{"text": "NS1", "start": 20, "end": 23}]}}, "schema": []}
{"input": "These are two regions of known conserved synteny, providing further evidence that the human STEP is a true homolog of the murine STEP gene.", "output": {"entities": {"gene": [{"text": "human STEP", "start": 86, "end": 96}, {"text": "murine STEP gene", "start": 122, "end": 138}]}}, "schema": []}
{"input": "Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci.", "output": {"entities": {"gene": [{"text": "striatum-enriched phosphatase (STEP) gene", "start": 44, "end": 85}]}}, "schema": []}
{"input": "Carbonic anhydrase V (CA V) is expressed in mitochondrial matrix in liver and several other tissues.", "output": {"entities": {"gene": [{"text": "Carbonic anhydrase V", "start": 0, "end": 20}, {"text": "CA V", "start": 22, "end": 26}]}}, "schema": []}
{"input": "Vitamin D3 plus nicotine treatment produced parallel increases in cardiac mass and elastic modulus, with a significant correlation between the two.", "output": {"entities": {}}, "schema": []}
{"input": "The latter domain appears to be involved in targeting Num1p to the mother cell cortex.", "output": {"entities": {"gene": [{"text": "Num1p", "start": 54, "end": 59}]}}, "schema": []}
{"input": "This finding is consistent with the notion that the dsRNA binding domains may be composed of two separate functional subdomains.", "output": {"entities": {}}, "schema": []}
{"input": "Preferential heterodimeric parallel coiled-coil formation by synthetic Max and c-Myc leucine zippers: a description of putative electrostatic interactions responsible for the specificity of heterodimerization.", "output": {"entities": {"gene": [{"text": "synthetic Max", "start": 61, "end": 74}, {"text": "c-Myc leucine zippers", "start": 79, "end": 100}]}}, "schema": []}
{"input": "Comparison to other coxI genes revealed a 966-bp group I intron, which, based on homology with the related yeast coxI intron aI4, potentially encodes a 279-amino-acid site-specific DNA endonuclease.", "output": {"entities": {"gene": [{"text": "coxI genes", "start": 20, "end": 30}, {"text": "yeast coxI intron aI4", "start": 107, "end": 128}, {"text": "DNA endonuclease", "start": 181, "end": 197}]}}, "schema": []}
{"input": "We studied the GR in DMS-79 cells derived from a human ACTH-secreting small cell lung cancer.", "output": {"entities": {"gene": [{"text": "GR", "start": 15, "end": 17}, {"text": "ACTH", "start": 55, "end": 59}]}}, "schema": []}
{"input": "This study analyzed whether the localization of an accessory pathway could be predicted by using the polarity of the QRS complex during sinus rhythm on the surface ECG, instead of the delta wave polarity as used in many reports.", "output": {"entities": {}}, "schema": []}
{"input": "The promoter mutation is complemented in trans by E1A products of the heterologous helper adenovirus type 5 (Ad5).", "output": {"entities": {"gene": [{"text": "E1A", "start": 50, "end": 53}]}}, "schema": []}
{"input": "Thus, as expected, trans-splicing depends on the integrity of U2, U4, and U6 snRNAs.", "output": {"entities": {"gene": [{"text": "U2", "start": 62, "end": 64}, {"text": "U4", "start": 66, "end": 68}, {"text": "U6 snRNAs", "start": 74, "end": 83}]}}, "schema": []}
{"input": "Treatment of PCC4. aza1R cells with an RAR-selective agonist also repressed the expression of EC-1 mRNA while treatment with an RXR-selective agonist reduced EC-1 expression slightly.", "output": {"entities": {"gene": [{"text": "RAR", "start": 39, "end": 42}, {"text": "EC-1 mRNA", "start": 94, "end": 103}, {"text": "RXR", "start": 128, "end": 131}, {"text": "EC-1", "start": 158, "end": 162}]}}, "schema": []}
{"input": "Shift-down experiments indicated that the 10 (4)-to 10 (5)-fold reduction in virus yield at the nonpermissive temperature was due to the disfunction of alpha TIF late in infection, presumably in virion maturation.", "output": {"entities": {"gene": [{"text": "alpha TIF", "start": 152, "end": 161}]}}, "schema": []}
{"input": "These results demonstrate that tip acts at an early stage of the T-cell signal transduction cascade by associating with Lck and downregulating Lck-mediated activation.", "output": {"entities": {"gene": [{"text": "tip", "start": 31, "end": 34}, {"text": "Lck", "start": 120, "end": 123}]}}, "schema": []}
{"input": "Human immunodeficiency virus type 1 Vpr is a virion-associated, regulatory protein that is required for efficient viral replication in monocytes/macrophages.", "output": {"entities": {"gene": [{"text": "Human immunodeficiency virus type 1 Vpr", "start": 0, "end": 39}]}}, "schema": []}
{"input": "Here we examine the potential for VP16 protein-protein interactions specific to virus-infected cells and show that VP16 copurifies in a highly enriched fraction with a single major polypeptide which we identify as the virus-encoded structural protein VP22.", "output": {"entities": {"gene": [{"text": "VP16", "start": 34, "end": 38}, {"text": "VP16", "start": 115, "end": 119}, {"text": "VP22", "start": 251, "end": 255}]}}, "schema": []}
{"input": "Thus, transcriptional regulation, splicing, kinase interaction sites, and tyrosine phosphorylation of the LMP2A homologs have been conserved despite significant sequences heterogeneity in the preterminal repeat regions of these human and nonhuman primate EBVs.", "output": {"entities": {"gene": [{"text": "LMP2A homologs", "start": 106, "end": 120}]}}, "schema": []}
{"input": "Results of the ECAT Angina Pectoris Study Group.", "output": {"entities": {}}, "schema": []}
{"input": "Therefore, a prospective Phase II trial was conducted to determine the safety and efficacy of cryosurgery following radiation therapy in men with local recurrence.", "output": {"entities": {}}, "schema": []}
{"input": "These motifs include a Chi motif and a Chi-like element previously found in the recombination hotspot region of the Bcl-2 proto-oncogene and close to chromosomal breakpoints in T-ALL lines.", "output": {"entities": {"gene": [{"text": "Bcl-2 proto-oncogene", "start": 116, "end": 136}]}}, "schema": []}
{"input": "Common history and prospects in surgical gynecology of the Charite and the Vienna University Clinic", "output": {"entities": {}}, "schema": []}
{"input": "In contrast with the previously reported HMGR1 mRNA (HMGR1S mRNA), which is detected at high levels in all tissues of the plant, HMGR1L mRNA is present at relatively low levels and its expression is restricted mostly to seedlings, roots and inflorescences.", "output": {"entities": {"gene": [{"text": "HMGR1 mRNA", "start": 41, "end": 51}, {"text": "HMGR1S mRNA", "start": 53, "end": 64}, {"text": "HMGR1L mRNA", "start": 129, "end": 140}]}}, "schema": []}
{"input": "However, the requirement of rev3 for the production of G. C--> T. A transversions by the rad18 mutator, which induces only these substitutions, was similar to that for rad6-mediated G. C--> T. A transversion.", "output": {"entities": {"gene": [{"text": "rev3", "start": 28, "end": 32}, {"text": "rad18 mutator", "start": 89, "end": 102}, {"text": "rad6", "start": 168, "end": 172}]}}, "schema": []}
{"input": "The second mutation present in the original mutant proved to be an allele of a known gene, PBS2, which encodes a putative protein kinase that functions in the high osmolarity stress pathway.", "output": {"entities": {"gene": [{"text": "PBS2", "start": 91, "end": 95}]}}, "schema": []}
{"input": "In adult tissues, it was less restricted, indicating that RAFTK expression is developmentally up-regulated.", "output": {"entities": {"gene": [{"text": "RAFTK", "start": 58, "end": 63}]}}, "schema": []}
{"input": "As hGM-CSF receptor (hGMR) does not contain a consensus sequence for binding of PI 3-kinase, hGMR must use a distinct mechanism for its association with and activation of PI 3-kinase.", "output": {"entities": {"gene": [{"text": "hGM-CSF receptor", "start": 3, "end": 19}, {"text": "hGMR", "start": 21, "end": 25}, {"text": "PI 3-kinase", "start": 80, "end": 91}, {"text": "hGMR", "start": 93, "end": 97}, {"text": "PI 3-kinase", "start": 171, "end": 182}]}}, "schema": []}
{"input": "J.", "output": {"entities": {}}, "schema": []}
{"input": "The identity between hnRNPs H and H' is 96%, between H and F 78%, and between H' and F 75%, respectively.", "output": {"entities": {"gene": [{"text": "hnRNPs H", "start": 21, "end": 29}, {"text": "H'", "start": 34, "end": 36}, {"text": "H", "start": 53, "end": 54}, {"text": "F", "start": 59, "end": 60}, {"text": "H'", "start": 78, "end": 80}, {"text": "F", "start": 85, "end": 86}]}}, "schema": []}
{"input": "In the present study, we transiently expressed in primary cultures of rat hepatocytes plasmids consisting of CYP3A1 5'-flanking sequences fused to a chloramphenicol acetyltransferase reporter plasmid.", "output": {"entities": {"gene": [{"text": "CYP3A1 5'-flanking sequences", "start": 109, "end": 137}, {"text": "chloramphenicol acetyltransferase reporter", "start": 149, "end": 191}]}}, "schema": []}
{"input": "We show that stimulation of resting splenic B cells with CD40L-expressing Sf9 cells induces germ-line gamma 1 and epsilon transcripts independently of cytokines.", "output": {"entities": {"gene": [{"text": "CD40L", "start": 57, "end": 62}]}}, "schema": []}
{"input": "At the time of the 13 latest BPVs, age ranged from three days to 13. 1 years (mean 5. 7 +/-SD 4. 8 years).", "output": {"entities": {}}, "schema": []}
{"input": "A tobacco homologue (trolC) of the rolC gene of the Agrobacterium rhizogenes Ri-plasmid was cloned and sequenced from Nicotiana tabacum L. cv.", "output": {"entities": {"gene": [{"text": "trolC", "start": 21, "end": 26}, {"text": "rolC gene of the Agrobacterium rhizogenes Ri-plasmid", "start": 35, "end": 87}]}}, "schema": []}
{"input": "High ADR1 gene dosage increased the transcription of genes encoding peroxisomal proteins as compared to one copy of the ADR1 gene.", "output": {"entities": {"gene": [{"text": "ADR1 gene", "start": 5, "end": 14}, {"text": "ADR1 gene", "start": 120, "end": 129}]}}, "schema": []}
{"input": "Of the three known C/EBP family inhibitors, Ig/EBP, LIP and CHOP-10, only Ig/EBP is ubiquitously expressed.", "output": {"entities": {"gene": [{"text": "C/EBP family", "start": 19, "end": 31}, {"text": "Ig/EBP", "start": 44, "end": 50}, {"text": "LIP", "start": 52, "end": 55}, {"text": "CHOP-10", "start": 60, "end": 67}, {"text": "Ig/EBP", "start": 74, "end": 80}]}}, "schema": []}
{"input": "The effects of a 1-or 24-hour pretreatment regimen with monophosphoryl lipid A (MLA, 35 micrograms/kg i. v.) on myocardial stunning produced by repetitive coronary occlusions were studied in barbital-anesthetized dogs.", "output": {"entities": {}}, "schema": []}
{"input": "A platelet-derived growth factor receptor (PDGF-R) phosphopeptide containing Tyr-857 does not bind appreciably to the Src SH2 domain, suggesting it is not the PDGF-R binding site for Src as previously reported.", "output": {"entities": {"gene": [{"text": "platelet-derived growth factor receptor", "start": 2, "end": 41}, {"text": "PDGF-R", "start": 43, "end": 49}, {"text": "Src SH2 domain", "start": 118, "end": 132}, {"text": "PDGF-R", "start": 159, "end": 165}, {"text": "Src", "start": 183, "end": 186}]}}, "schema": []}
{"input": "We have also tested Src SH2 mutants for their binding properties and have interpreted our results in light of the recent crystal structure solution for the Src SH2 domain.", "output": {"entities": {"gene": [{"text": "Src SH2", "start": 20, "end": 27}, {"text": "Src SH2", "start": 156, "end": 163}]}}, "schema": []}
{"input": "These observations link actin plaque assembly to increased cell substrate adhesion.", "output": {"entities": {"gene": [{"text": "actin", "start": 24, "end": 29}]}}, "schema": []}
{"input": "The early lethality of the left-sided resectio was 0% and the postoperative survival--5-10 months.", "output": {"entities": {}}, "schema": []}
{"input": "There are two immunogenic sites on the type A influenza A/Japan/57 (H2N2) hemagglutinin (HA) that can be recognized by class I major histocompatibility complex (MHC), H-2Kd-restricted cytolytic T lymphocytes (CTLs).", "output": {"entities": {"gene": [{"text": "hemagglutinin", "start": 74, "end": 87}, {"text": "HA", "start": 89, "end": 91}, {"text": "class I major histocompatibility complex", "start": 119, "end": 159}, {"text": "MHC", "start": 161, "end": 164}, {"text": "H-2Kd", "start": 167, "end": 172}]}}, "schema": []}
{"input": "This enhancer activates both the K19 and TK basal promoters in HeLa cells.", "output": {"entities": {"gene": [{"text": "K19", "start": 33, "end": 36}, {"text": "TK basal promoters", "start": 41, "end": 59}]}}, "schema": []}
{"input": "Interestingly, one IRF binding site was found within the IRF-2 promoter, and expression of the IRF-2 gene was affected by both transient and stable IRF-1 expression.", "output": {"entities": {"gene": [{"text": "IRF binding site", "start": 19, "end": 35}, {"text": "IRF-2 promoter", "start": 57, "end": 71}, {"text": "IRF-2 gene", "start": 95, "end": 105}, {"text": "IRF-1", "start": 148, "end": 153}]}}, "schema": []}
{"input": "Therefore, we studied ninety coagulopathic patients with the aim of determining the prevalence of hepatitis C virus (HCV) antibodies using the ELISA and RIBA methods.", "output": {"entities": {"gene": [{"text": "hepatitis C virus (HCV) antibodies", "start": 98, "end": 132}]}}, "schema": []}
{"input": "The highest decrease in mutagenic activity was observed when enzymatic bleaching was used together with chlorine.", "output": {"entities": {}}, "schema": []}
{"input": "There was also a highly significant correlation between total selenium intake and liver selenium concentration (r = 0. 99, p < 0. 01) after 1 mo of treatment, but this time liver selenium did not change with time, and the correlation remained highly significant throughout the investigation.", "output": {"entities": {}}, "schema": []}
{"input": "Antibodies affinity-purified using the bacterially expressed recombinant protein recognized the 56K autoantigen in a HeLa cell extract. cDNA sequencing revealed that the 56K cDNA shares a high degree of homology in both nucleotide (87%) and amino acid sequence (92. 5%) with bovine annexin XI, indicating that the 56K cDNA encodes the human homologue of annexin XI, a member of the Ca (2 +)-dependent phospholipid binding protein family.", "output": {"entities": {"gene": [{"text": "56K autoantigen", "start": 96, "end": 111}, {"text": "56K cDNA", "start": 170, "end": 178}, {"text": "bovine annexin XI", "start": 275, "end": 292}, {"text": "56K cDNA", "start": 314, "end": 322}, {"text": "human homologue of annexin XI", "start": 335, "end": 364}, {"text": "Ca (2 +)-dependent phospholipid binding protein family", "start": 382, "end": 436}]}}, "schema": []}
{"input": "The avidin-biotin complex peroxidase (ABC-P) method was used to detect Mycobacterium bovis, and the results were compared with those obtained by the Ziehl-Neelsen (ZN) technique.", "output": {"entities": {"gene": [{"text": "avidin-biotin complex peroxidase", "start": 4, "end": 36}, {"text": "ABC-P", "start": 38, "end": 43}]}}, "schema": []}
{"input": "Its role in these processes suggests that the function of c-Myb may be important early in the establishment of the hematopoietic lineage.", "output": {"entities": {"gene": [{"text": "c-Myb", "start": 58, "end": 63}]}}, "schema": []}
{"input": "The transforming gene of the avian sarcoma virus CT10 encodes a fusion protein (p47gag-crk or v-Crk) containing viral Gag sequences fused to cellular sequences consisting primarily of Src homology regions 2 and 3 (SH2 and SH3 sequences).", "output": {"entities": {"gene": [{"text": "avian sarcoma virus CT10", "start": 29, "end": 53}, {"text": "p47gag", "start": 80, "end": 86}, {"text": "crk", "start": 87, "end": 90}, {"text": "v-Crk", "start": 94, "end": 99}, {"text": "viral Gag sequences", "start": 112, "end": 131}, {"text": "Src homology regions 2 and 3", "start": 184, "end": 212}, {"text": "SH2", "start": 214, "end": 217}, {"text": "SH3 sequences", "start": 222, "end": 235}]}}, "schema": []}
{"input": "This specific methylation pattern caused inactivation of the HSV tk gene, while methylation of the cytosine residues within the nucleotide sequence from + 811 to + 1309 had no effect on HSV tk gene activity.", "output": {"entities": {"gene": [{"text": "HSV tk gene", "start": 61, "end": 72}, {"text": "HSV tk gene", "start": 186, "end": 197}]}}, "schema": []}
{"input": "CONCLUSION: This study documents that regression of choroidal neovascularization that occurred with alpha interferon treatment was minimal.", "output": {"entities": {"gene": [{"text": "alpha interferon", "start": 100, "end": 116}]}}, "schema": []}
{"input": "Long-range mapping of the 11q23 region involved in chromosome aberrations in human tumors by pulsed-field gel electrophoresis with a yeast artificial chromosome.", "output": {"entities": {}}, "schema": []}
{"input": "GTRE, TRE, and CRE oligonucleotides all compete more efficiently for protein binding to their labeled congeners than for protein binding to either of the other labeled oligonucleotides, suggesting that the GTRE, TRE, and CRE oligonucleotides, suggesting that the GTRE, TRE, and CRE oligonucleotides each bind unique as well as common proteins, likely to be members of the Jun/Fos and cAMP-responsive element-binding protein/activating transcription factors (CREB/ATF) families of transcription factors, in chromaffin cells.", "output": {"entities": {"gene": [{"text": "Jun", "start": 372, "end": 375}, {"text": "Fos", "start": 376, "end": 379}, {"text": "cAMP-responsive element-binding protein", "start": 384, "end": 423}, {"text": "activating transcription factors", "start": 424, "end": 456}, {"text": "CREB", "start": 458, "end": 462}, {"text": "ATF", "start": 463, "end": 466}]}}, "schema": []}
{"input": "One patient only had any test abnormalities.", "output": {"entities": {}}, "schema": []}
{"input": "One antibody, mAb1C2, and a synthetic peptide comprising its epitope selectively inhibited in vitro transcription from TATA-containing, but not from TATA-less promoters, irrespective of whether they were transcribed by Pol II or Pol III.", "output": {"entities": {"gene": [{"text": "mAb1C2", "start": 14, "end": 20}, {"text": "Pol II", "start": 219, "end": 225}, {"text": "Pol III", "start": 229, "end": 236}]}}, "schema": []}
{"input": "The lymph nodes from two of the patients with rheumatoid arthritis contained numerous sarcoid like granulomata, further indicating a possible association between sarcoidosis and rheumatoid arthritis.", "output": {"entities": {}}, "schema": []}
{"input": "HCV infection acquired during or after BMT caused only mild acute hepatitis C, which progressed to chronic hepatitis C in one patient surviving 10 years after BMT.", "output": {"entities": {}}, "schema": []}
{"input": "Hepatitis C virus infection is a risk factor for liver failure from veno-occlusive disease after bone marrow transplantation.", "output": {"entities": {}}, "schema": []}
{"input": "High plasma concentrations of soluble E-selectin were closely associated with multiple-organ dysfunction and death.", "output": {"entities": {"gene": [{"text": "E-selectin", "start": 38, "end": 48}]}}, "schema": []}
{"input": "These human IFN-beta-transformed cell populations have acquired a low, constitutive production of human IFN, while replicating at a rate similar to that of untransformed cells and of cells transformed with the control vector carrying a human IFN-beta sequence encoding an inactive, mutated protein.", "output": {"entities": {"gene": [{"text": "IFN-beta", "start": 12, "end": 20}, {"text": "human IFN", "start": 98, "end": 107}, {"text": "human IFN-beta sequence", "start": 236, "end": 259}]}}, "schema": []}
{"input": "Improvement of the polypyrimidine tract also increased the splicing efficiency, but to a degree slightly less than that obtained with the branchpoint mutation.", "output": {"entities": {}}, "schema": []}
{"input": "Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.", "output": {"entities": {"gene": [{"text": "SH2-containing protein tyrosine phosphatase", "start": 18, "end": 61}, {"text": "SH-PTP2", "start": 63, "end": 70}, {"text": "insulin receptor substrate-1", "start": 124, "end": 152}]}}, "schema": []}
{"input": "In contrast, injection of a plasmid encoding simian virus 40 small t antigen, which interacts with PP2A to inhibit its activity towards several phosphoprotein substrates, had no effect on the phosphorylation state of CREB in stimulated or unstimulated NIH 3T3 cells.", "output": {"entities": {"gene": [{"text": "simian virus 40 small t antigen", "start": 45, "end": 76}, {"text": "PP2A", "start": 99, "end": 103}, {"text": "CREB", "start": 217, "end": 221}]}}, "schema": []}
{"input": "Several Src SH3-binding proteins were phosphorylated in Src-transformed cells.", "output": {"entities": {"gene": [{"text": "Src SH3-binding proteins", "start": 8, "end": 32}, {"text": "Src", "start": 56, "end": 59}]}}, "schema": []}
{"input": "We also examined the effect of proteolytic processing in the MVE nonstructural polyprotein segment mediated by the viral proteinase NS3 on antigen processing and presentation of the MVE H-2Kk-restricted T cell determinant.", "output": {"entities": {"gene": [{"text": "viral proteinase NS3", "start": 115, "end": 135}]}}, "schema": []}
{"input": "A full-length PRL receptor (PRLR) complementary DNA from pigeons was obtained by screening pigeon crop sac libraries and by reverse transcription coupled with polymerase chain reaction.", "output": {"entities": {"gene": [{"text": "full-length PRL receptor", "start": 2, "end": 26}, {"text": "PRLR", "start": 28, "end": 32}]}}, "schema": []}
{"input": "After 7 days, a spontaneous regression of the morphologic alterations caused by caerulein-induced acute pancreatitis occurs; however, recovery of the secretory function of the pancreas was only reached after this period of time when L-364, 718 was administered therapeutically (0. 1 mg/kg/day).", "output": {"entities": {}}, "schema": []}
{"input": "We observed that dephosphorylation severely inhibits the DNA-binding ability of C/EBP-delta and its transactivating potential increases in the presence of cellular phosphatase inhibitors, such as okadaic acid and sodium orthovanadate.", "output": {"entities": {"gene": [{"text": "C/EBP-delta", "start": 80, "end": 91}]}}, "schema": []}
{"input": "Two promoters were identified by S1 nuclease mapping: P1, which lies about 72 bp upstream from the structural gene; and P2, which lies about 35 bp upstream.", "output": {"entities": {"gene": [{"text": "S1 nuclease", "start": 33, "end": 44}]}}, "schema": []}
{"input": "On the other hand, cells containing a PTP1C in which the catalytic site had been inactivated through mutagenesis, stably phosphorylated the phosphatase.", "output": {"entities": {"gene": [{"text": "PTP1C", "start": 38, "end": 43}]}}, "schema": []}
{"input": "We recently found that the p72syk protein tyrosine kinase is physically associated with the TCR/CD3 complex and is rapidly tyrosine phosphorylated and activated by receptor triggering also in T cells lacking p56lck.", "output": {"entities": {"gene": [{"text": "p72syk protein tyrosine kinase", "start": 27, "end": 57}, {"text": "TCR", "start": 92, "end": 95}, {"text": "CD3", "start": 96, "end": 99}, {"text": "p56lck", "start": 208, "end": 214}]}}, "schema": []}
{"input": "The transforming protein of Rous sarcoma virus, pp60v-src, and its normal cellular homolog, pp60c-src, differ not only in oncogenic potential but also in their subcellular localization and cytoskeletal binding ability. pp60v-src has been shown to stably associate with a detergent-insoluble cytoskeletal matrix, whereas pp60c-src does not.", "output": {"entities": {"gene": [{"text": "pp60v-src", "start": 48, "end": 57}, {"text": "pp60c-src", "start": 92, "end": 101}, {"text": "pp60v-src", "start": 219, "end": 228}, {"text": "pp60c-src", "start": 320, "end": 329}]}}, "schema": []}
{"input": "Organization of the bovine gene encoding the endothelial nitric oxide synthase.", "output": {"entities": {"gene": [{"text": "endothelial nitric oxide synthase", "start": 45, "end": 78}]}}, "schema": []}
{"input": "We determined whether regional myocardial work efficiency (segment work/regional O2 consumption) would be elevated by surgically-augmented inflow.", "output": {"entities": {}}, "schema": []}
{"input": "In female Sl (pan)/Sl (pan) mice, ovarian follicle development is arrested at the one layered cuboidal stage as a result of reduced KL expression in follicle cells, indicating a role for c-kit in oocyte growth.", "output": {"entities": {"gene": [{"text": "Sl (pan)/Sl (pan)", "start": 10, "end": 27}, {"text": "KL", "start": 132, "end": 134}, {"text": "c-kit", "start": 187, "end": 192}]}}, "schema": []}
{"input": "Anti-NPROSP-C also exclusively detected time-dependent appearances of 5-10-kDa proSP-C forms in lamellar bodies and homogenates.", "output": {"entities": {"gene": [{"text": "Anti-NPROSP-C", "start": 0, "end": 13}, {"text": "5-10-kDa proSP-C", "start": 70, "end": 86}]}}, "schema": []}
{"input": "In the B6-derived Db mutant B6. CH-2bm13 (bm13) strain, part of the class I Db antigen-presenting groove is shaped by a class I Kb-encoded sequence.", "output": {"entities": {"gene": [{"text": "Db mutant B6. CH-2bm13 (bm13)", "start": 18, "end": 47}, {"text": "class I Db antigen-presenting groove", "start": 68, "end": 104}, {"text": "class I Kb-encoded sequence", "start": 120, "end": 147}]}}, "schema": []}
{"input": "Our findings confirm the high frequency of proximal nerve lesions in early GBS and CIDP, not all of which are associated with distal motor conduction abnormalities, and suggest that assessment of multiple F wave parameters, in particular chronodispersion, mean latency and mean amplitude (in addition to absence and minimum latency), increases the yield of F wave studies.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of alterations of primer-binding site sequences on human immunodeficiency virus type 1 replication.", "output": {"entities": {}}, "schema": []}
{"input": "Presentation of a horse cytochrome c peptide by multiple H-2b class I major histocompatibility complex (MHC) molecules to C57BL/6-and bm1-derived cytotoxic T lymphocytes: presence of a single MHC anchor residue may confer efficient peptide-specific CTL recognition.", "output": {"entities": {"gene": [{"text": "horse cytochrome c peptide", "start": 18, "end": 44}, {"text": "H-2b class I major histocompatibility complex", "start": 57, "end": 102}, {"text": "MHC", "start": 104, "end": 107}, {"text": "MHC anchor residue", "start": 192, "end": 210}]}}, "schema": []}
{"input": "Diagnosis of prostatic carcinoma: the yield of serum prostate specific antigen, digital rectal examination and transrectal ultrasonography.", "output": {"entities": {"gene": [{"text": "serum prostate specific antigen", "start": 47, "end": 78}]}}, "schema": []}
{"input": "Increased granulocyte-colony stimulating factor (G-CSF) levels in neonates with perinatal complications.", "output": {"entities": {"gene": [{"text": "granulocyte-colony stimulating factor", "start": 10, "end": 47}, {"text": "G-CSF", "start": 49, "end": 54}]}}, "schema": []}
{"input": "The results revealed a hierarchy of ligand affinities that mirrored their adhesive activity (rsVCAM-1 > fibronectin variants containing CS1 > > other fibronectin variants).", "output": {"entities": {"gene": [{"text": "rsVCAM-1", "start": 93, "end": 101}, {"text": "fibronectin variants", "start": 104, "end": 124}, {"text": "CS1", "start": 136, "end": 139}, {"text": "fibronectin variants", "start": 150, "end": 170}]}}, "schema": []}
{"input": "When expressed in and purified from Escherichia coli, both full-length Fpr3 and its isolated COOH-terminal domain exhibit readily detectable PPIase activity.", "output": {"entities": {"gene": [{"text": "full-length Fpr3", "start": 59, "end": 75}, {"text": "PPIase", "start": 141, "end": 147}]}}, "schema": []}
{"input": "However, expression of sigma 3 from S4 (3' UTR/S1), which included the PKR activator sequence from S1 within the 3'-UTR of S4, was comparable to that from wild-type S4.", "output": {"entities": {"gene": [{"text": "sigma 3", "start": 23, "end": 30}, {"text": "S4", "start": 36, "end": 38}, {"text": "3' UTR/S1", "start": 40, "end": 49}, {"text": "PKR activator sequence", "start": 71, "end": 93}, {"text": "S1", "start": 99, "end": 101}, {"text": "3'-UTR of S4", "start": 113, "end": 125}, {"text": "wild-type S4", "start": 155, "end": 167}]}}, "schema": []}
{"input": "Microvessels were counted in a x200 field (0. 754 mm2) in the area of maximal angiogenesis.", "output": {"entities": {}}, "schema": []}
{"input": "Recent studies have demonstrated that the activated GH receptor can stimulate Stat1, a cytoplasmic transcription factor that becomes tyrosine phosphorylated and translocates to the nucleus, where it can interact with specific DNA sequences to modulate gene expression.", "output": {"entities": {"gene": [{"text": "GH receptor", "start": 52, "end": 63}, {"text": "Stat1", "start": 78, "end": 83}]}}, "schema": []}
{"input": "In viral infections, G-CSF was correlated with mononuclear cells (rs = 0. 41, P < 0. 05), white blood cell counts (rs = 0. 56, P < 0. 01), neutrophils (rs = 0. 41, P < 0. 05) and CRP (rs = 0. 47, P < 0. 05).", "output": {"entities": {"gene": [{"text": "G-CSF", "start": 21, "end": 26}, {"text": "CRP", "start": 179, "end": 182}]}}, "schema": []}
{"input": "Minor initiation sites were found at positions-128,-111,-91, and-74.", "output": {"entities": {}}, "schema": []}
{"input": "Phosphoamino acid analysis of radiolabeled ASGPR subunits identified Ser (P) as the predominant (approximately 95%) and Thr (P) as a minor (approximately 5%) phosphoamino acid in each polypeptide and confirmed the presence of Tyr (P) (approximately 1%) in RHL1.", "output": {"entities": {"gene": [{"text": "ASGPR subunits", "start": 43, "end": 57}, {"text": "RHL1", "start": 256, "end": 260}]}}, "schema": []}
{"input": "To further define the structural requirements for ZAP-70 interaction with the TCR, we developed a binding assay using immobilized glutathione S-transferase fusion proteins containing the NH2-and/or COOH-terminal SH2 domains of ZAP-70, and soluble synthetic peptides with the sequence of the cytoplasmic region of the TCR zeta chain (TCR zeta cyt) or individual TCR zeta and CD3 epsilon TAM motifs.", "output": {"entities": {"gene": [{"text": "ZAP-70", "start": 50, "end": 56}, {"text": "TCR", "start": 78, "end": 81}, {"text": "glutathione S-transferase fusion proteins", "start": 130, "end": 171}, {"text": "COOH-terminal SH2 domains", "start": 198, "end": 223}, {"text": "ZAP-70", "start": 227, "end": 233}, {"text": "TCR zeta chain", "start": 317, "end": 331}, {"text": "TCR zeta cyt", "start": 333, "end": 345}, {"text": "TCR zeta", "start": 361, "end": 369}, {"text": "CD3 epsilon TAM motifs", "start": 374, "end": 396}]}}, "schema": []}
{"input": "All four doubly tyrosine phosphorylated TAM peptides cross-compete with each other for binding to the tandem SH2 domains of ZAP-70.", "output": {"entities": {"gene": [{"text": "SH2 domains", "start": 109, "end": 120}, {"text": "ZAP-70", "start": 124, "end": 130}]}}, "schema": []}
{"input": "The three-dimensional structure of RT shows that it is a strikingly asymmetric heterodimer consisting of two differently folded subunits (molecular weights 66 kDa and 51 kDa) with identical amino-terminal amino acid sequences (residues 1-428).", "output": {"entities": {"gene": [{"text": "RT", "start": 35, "end": 37}]}}, "schema": []}
{"input": "Pharmacological and pharmacokinetic characteristics of the non-ionic monomeric X-ray contrast agent iopromide (Ultravist, CAS 73334-07-3) were evaluated in preclinical studies.", "output": {"entities": {}}, "schema": []}
{"input": "All subsequent patients were treated at the maximal tolerated dose of EDXR (35 mg/m2/day).", "output": {"entities": {}}, "schema": []}
{"input": "Addition of soluble recombinant human SLF to SI4-h220 cultures enhanced reduction of cell-surface c-kit expression and its protein degradation.", "output": {"entities": {"gene": [{"text": "recombinant human SLF", "start": 20, "end": 41}, {"text": "c-kit", "start": 98, "end": 103}]}}, "schema": []}
{"input": "Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form.", "output": {"entities": {"gene": [{"text": "Steel factor", "start": 15, "end": 27}, {"text": "tyrosine kinase", "start": 52, "end": 67}, {"text": "c-kit", "start": 103, "end": 108}]}}, "schema": []}
{"input": "Analysis of the sequences with the BLAST and GRAIL programs provided additional independent evidence that 15 of these 17 clones contain coding sequences and that nine other clones are likely to contain sequences coding for portions of new genes.", "output": {"entities": {}}, "schema": []}
{"input": "Patients with more than 250 PVC/24 hours were selected for distribution of PVC and CI evaluation.", "output": {"entities": {}}, "schema": []}
{"input": "Horvath, I.", "output": {"entities": {}}, "schema": []}
{"input": "Cell lines derived from the tumors were examined by fluorescent in situ hybridization for the status of the transferred human chromosome and by PCR for marker loss.", "output": {"entities": {}}, "schema": []}
{"input": "However, multiple alanine substitutions or proline (helix-destabilizing) substitutions disrupted both oligomerization and transport of GP64 EFP.", "output": {"entities": {"gene": [{"text": "GP64 EFP", "start": 135, "end": 143}]}}, "schema": []}
{"input": "The FinO protein of IncF plasmids binds FinP antisense RNA and its target, traJ mRNA, and promotes duplex formation.", "output": {"entities": {"gene": [{"text": "FinO protein", "start": 4, "end": 16}, {"text": "FinP antisense RNA", "start": 40, "end": 58}, {"text": "traJ mRNA", "start": 75, "end": 84}]}}, "schema": []}
{"input": "We linked a 4. 1-kilobase pair HindIII DNA fragment from the region upstream of the human AP endonuclease gene (APE) to the chloramphenicol acetyltransferase (CAT) gene.", "output": {"entities": {"gene": [{"text": "HindIII DNA fragment", "start": 31, "end": 51}, {"text": "human AP endonuclease gene", "start": 84, "end": 110}, {"text": "APE", "start": 112, "end": 115}, {"text": "chloramphenicol acetyltransferase", "start": 124, "end": 157}, {"text": "CAT", "start": 159, "end": 162}]}}, "schema": []}
{"input": "The overexpressed His6-tagged GrsA derivatives were affinity-purified, and the catalytic properties of the deletion mutants were examined by biochemical studies including ATP-dependent amino acid activation, carboxyl thioester formation, and the ability to racemize the covalently bound phenylalanine from L-to the D-isomer.", "output": {"entities": {"gene": [{"text": "His6-tagged GrsA derivatives", "start": 18, "end": 46}]}}, "schema": []}
{"input": "CD7 +/CD3-T-cell precursors exhibit V delta 2D delta 3 rearrangements.", "output": {"entities": {"gene": [{"text": "CD7", "start": 0, "end": 3}, {"text": "CD3", "start": 6, "end": 9}, {"text": "V delta 2D delta 3 rearrangements", "start": 36, "end": 69}]}}, "schema": []}
{"input": "HVH2 mRNA showed an expression pattern distinct from CL100 (human homologue of mouse MKP1) and PAC1, two previously identified MAP kinase phosphatases.", "output": {"entities": {"gene": [{"text": "HVH2 mRNA", "start": 0, "end": 9}, {"text": "CL100", "start": 53, "end": 58}, {"text": "human homologue of mouse MKP1", "start": 60, "end": 89}, {"text": "PAC1", "start": 95, "end": 99}, {"text": "MAP kinase phosphatases", "start": 127, "end": 150}]}}, "schema": []}
{"input": "These data suggest that these sequences located immediately 3' to the breakpoint of the HPFH-3 deletion, exhibit both the structure and the function of an enhancer, and can modify the developmental specificity of the fetal gamma-globin genes, resulting in their continued expression during adult life.", "output": {"entities": {"gene": [{"text": "HPFH-3 deletion", "start": 88, "end": 103}, {"text": "fetal gamma-globin genes", "start": 217, "end": 241}]}}, "schema": []}
{"input": "Our results indicate that interaction between Jak2 and PRLR requires a proline-rich sequence in the membrane proximal region of the receptor, which is conserved among the different members of the cytokine receptor superfamily.", "output": {"entities": {"gene": [{"text": "Jak2", "start": 46, "end": 50}, {"text": "PRLR", "start": 55, "end": 59}, {"text": "cytokine receptor superfamily", "start": 196, "end": 225}]}}, "schema": []}
{"input": "Transcription of the vascular cell adhesion molecule 1 (VCAM-1) gene in endothelial cells is induced by lipopolysaccharide and the inflammatory cytokines interleukin-1 beta and tumor necrosis factor alpha (TNF-alpha).", "output": {"entities": {"gene": [{"text": "vascular cell adhesion molecule 1", "start": 21, "end": 54}, {"text": "VCAM-1", "start": 56, "end": 62}, {"text": "cytokines interleukin-1 beta", "start": 144, "end": 172}, {"text": "tumor necrosis factor alpha", "start": 177, "end": 204}, {"text": "TNF-alpha", "start": 206, "end": 215}]}}, "schema": []}
{"input": "Experiments with recombinant proteins showed that p50/p65 and high-mobility-group I (Y) protein cooperatively facilitated the binding of IRF-1 to the VCAM1 IRF binding site and that IRF-1 physically interacted with p50 and with high-mobility-group I (Y) protein.", "output": {"entities": {"gene": [{"text": "p50", "start": 50, "end": 53}, {"text": "p65", "start": 54, "end": 57}, {"text": "high-mobility-group I (Y) protein", "start": 62, "end": 95}, {"text": "IRF-1", "start": 137, "end": 142}, {"text": "VCAM1 IRF binding site", "start": 150, "end": 172}, {"text": "IRF-1", "start": 182, "end": 187}, {"text": "p50", "start": 215, "end": 218}, {"text": "high-mobility-group I (Y) protein", "start": 228, "end": 261}]}}, "schema": []}
{"input": "Based on these results the minimal control element (AX 470) specifying the anterior boundary of Hox expression was designated as Hoxa-7 enhancer.", "output": {"entities": {"gene": [{"text": "Hox", "start": 96, "end": 99}, {"text": "Hoxa-7 enhancer", "start": 129, "end": 144}]}}, "schema": []}
{"input": "In this report we describe the isolation of a Fab fragment (Fab A8) showing a high relative affinity for the receptor (0. 5 nM).", "output": {"entities": {"gene": [{"text": "Fab fragment", "start": 46, "end": 58}, {"text": "Fab A8", "start": 60, "end": 66}]}}, "schema": []}
{"input": "MBP-Rep68 delta-mediated DNA-RNA helicase activity required ATP hydrolysis and the presence of Mg2 + ions and was inhibited by high ionic strength.", "output": {"entities": {"gene": [{"text": "MBP", "start": 0, "end": 3}, {"text": "Rep68 delta", "start": 4, "end": 15}]}}, "schema": []}
{"input": "To identify critical regions mediating growth signal transduction by hG-CSFR, deletions or site-directed amino acid substitutions were introduced into the cytoplasmic domain of hG-CSFR, and the mutant cDNAs were transfected into the murine interleukin-3 (IL-3)-dependent Ba/F3 and FDCP cell lines.", "output": {"entities": {"gene": [{"text": "hG-CSFR", "start": 69, "end": 76}, {"text": "hG-CSFR", "start": 177, "end": 184}, {"text": "murine interleukin-3", "start": 233, "end": 253}, {"text": "IL-3", "start": 255, "end": 259}]}}, "schema": []}
{"input": "When combined with independent activating mutations in the c-abl kinase domain or NH2-terminus, the G128R mutation blocked transformation by the double mutant, suggesting that the G128R mutant was unable to transform cells for trivial reasons.", "output": {"entities": {"gene": [{"text": "c-abl kinase domain", "start": 59, "end": 78}, {"text": "G128R", "start": 100, "end": 105}, {"text": "G128R mutant", "start": 180, "end": 192}]}}, "schema": []}
{"input": "Both mutations completely abolished binding of the Abl SH3 domain to proline-rich target proteins in a filter-binding assay.", "output": {"entities": {"gene": [{"text": "Abl SH3", "start": 51, "end": 58}]}}, "schema": []}
{"input": "Changes induced in the gills of milkfish (Chanos chanos Forsskal) fingerlings after acute exposure to nifurpirinol (Furanace; P-7138).", "output": {"entities": {}}, "schema": []}
{"input": "Retreatment of these 2 dogs resulted in a similar, but blunted, response to human immunoglobulin.", "output": {"entities": {"gene": [{"text": "human immunoglobulin", "start": 76, "end": 96}]}}, "schema": []}
{"input": "The levels of NSE and MBP in the IJVB were compared to those in the PVB.", "output": {"entities": {"gene": [{"text": "NSE", "start": 14, "end": 17}, {"text": "MBP", "start": 22, "end": 25}]}}, "schema": []}
{"input": "Morphologic variables included cancer volume, histologic grade, capsular penetration, seminal vesicle invasion, and lymph node metastasis.", "output": {"entities": {}}, "schema": []}
{"input": "Sequence analysis of these regions showed a CAAT box upstream of exon 1a and high G-C content regions within both P1 and P2.", "output": {"entities": {}}, "schema": []}
{"input": "The fusion proteins were tested by ELISA for reactivity with a panel of human anti-La sera in order to define the nature of the epitopes.", "output": {"entities": {"gene": [{"text": "human anti-La sera", "start": 72, "end": 90}]}}, "schema": []}
{"input": "GCD10 was first identified genetically as a translational repressor of GCN4.", "output": {"entities": {"gene": [{"text": "GCD10", "start": 0, "end": 5}, {"text": "GCN4", "start": 71, "end": 75}]}}, "schema": []}
{"input": "GCD10 binds RNA in vitro and we present strong biochemical evidence that it is identical to the RNA-binding subunit of yeast initiation factor-3 (eIF-3). eIF-3 is a multisubunit complex that stimulates translation initiation in vitro at several different steps.", "output": {"entities": {"gene": [{"text": "GCD10", "start": 0, "end": 5}, {"text": "yeast initiation factor-3", "start": 119, "end": 144}, {"text": "eIF-3", "start": 146, "end": 151}, {"text": "eIF-3", "start": 154, "end": 159}]}}, "schema": []}
{"input": "Sources of noise in these signals were evaluated in preparations stained with the potentiometric probe RH-414.", "output": {"entities": {}}, "schema": []}
{"input": "1993.", "output": {"entities": {}}, "schema": []}
{"input": "A transformation-competent mutant, like the wild-type E5 protein, bound the receptor and induced receptor tyrosine phosphorylation and down-regulation.", "output": {"entities": {"gene": [{"text": "wild-type E5 protein", "start": 44, "end": 64}]}}, "schema": []}
{"input": "We conclude that cAMP, acting through PKA, is an essential regulator of basal CFTR gene expression and may mediate an induction of CFTR in responsive cell types.", "output": {"entities": {"gene": [{"text": "PKA", "start": 38, "end": 41}, {"text": "CFTR gene", "start": 78, "end": 87}, {"text": "CFTR", "start": 131, "end": 135}]}}, "schema": []}
{"input": "Both PPC-1 and ALVA-31 cells display tumorigenesis and invasiveness in nude mice, whereas LNCap cells exhibit a less malignant phenotype, suggesting a correlation between CD44 variant (CD44v) expression and aggressive prostate tumor behavior.", "output": {"entities": {"gene": [{"text": "CD44 variant", "start": 171, "end": 183}, {"text": "CD44v", "start": 185, "end": 190}]}}, "schema": []}
{"input": "Two such genes, designated hsiggll150 and hsiggll295, were cloned and sequenced from genomic DNA.", "output": {"entities": {"gene": [{"text": "hsiggll150", "start": 27, "end": 37}, {"text": "hsiggll295", "start": 42, "end": 52}]}}, "schema": []}
{"input": "A retrospective epidemiological study is reported concerning burn injuries in 775 children hospitalized at the unit of burn care of Casablanca between 1985 and 1993.", "output": {"entities": {}}, "schema": []}
{"input": "Our results suggest that protein binding to the E2F-like sequences may act to reduce expression.", "output": {"entities": {"gene": [{"text": "E2F-like sequences", "start": 48, "end": 66}]}}, "schema": []}
{"input": "The RAD6/UBC2 gene from Saccharomyces cerevisiae encodes a ubiquitin-conjugating enzyme involved in DNA repair, induced mutagenesis, and sporulation.", "output": {"entities": {"gene": [{"text": "RAD6", "start": 4, "end": 8}, {"text": "UBC2", "start": 9, "end": 13}, {"text": "ubiquitin-conjugating enzyme", "start": 59, "end": 87}]}}, "schema": []}
{"input": "Echocardiography revealed right ventricular diastolic collapse (RVDC) without physical signs of cardiac tamponade.", "output": {"entities": {}}, "schema": []}
{"input": "In on-going screening programmes, the Haemoccult test consists of six slides and a test is considered positive if at least one slide is coloured.", "output": {"entities": {}}, "schema": []}
{"input": "We showed previously that a fusion protein (GAL4-p40) containing the DNA-binding domain of GAL4 and sequences of chicken l kappa B-alpha (p40) inhibits growth in the yeast Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "GAL4", "start": 44, "end": 48}, {"text": "p40", "start": 49, "end": 52}, {"text": "GAL4", "start": 91, "end": 95}, {"text": "chicken l kappa B-alpha", "start": 113, "end": 136}, {"text": "p40", "start": 138, "end": 141}]}}, "schema": []}
{"input": "We have demonstrated previously that two binding sites in the-184 HNF-3 beta promoter are recognized by widely distributed factors and that there is also a critical autoregulatory site, we identified a binding site for a cell-specific factor, LF-H3 beta, that may function in restricting HNF-3 beta gene expression to hepatocytes.", "output": {"entities": {"gene": [{"text": "-184 HNF-3 beta promoter", "start": 61, "end": 85}, {"text": "LF-H3 beta", "start": 243, "end": 253}, {"text": "HNF-3 beta gene", "start": 288, "end": 303}]}}, "schema": []}
{"input": "In 4 spinalized cats, the effects of afferent inputs from hindlimb cutaneous nerves (sural cutaneous nerve: Sur) on mono-and poly-synaptic reflex recorded from tail muscle motoneurons were studied before and after spinal lesioning at S2-3 level.", "output": {"entities": {}}, "schema": []}
{"input": "The flow rate of phosphate buffered saline through dermis was measured as a function of applied pressure.", "output": {"entities": {}}, "schema": []}
{"input": "However, parallax measurements showed that at 150K, collapse of Epon sections does not take place.", "output": {"entities": {}}, "schema": []}
{"input": "Although within normal limits, latency was high.", "output": {"entities": {}}, "schema": []}
{"input": "The outcome of the optimization of the seven-field plan prompted an investigation into the best results that could be achieved by an \" ideal \" conformal radiotherapy technique.", "output": {"entities": {}}, "schema": []}
{"input": "Specific requirements for branched-chain amino acids, glutamine, and arginine are evaluated.", "output": {"entities": {}}, "schema": []}
{"input": "The pea rps10 intron is homologous to introns in rrn26 and cox3 in the Marchantia mitochondrial genome, while the Marchantia rps10 gene lacks an intron.", "output": {"entities": {"gene": [{"text": "pea rps10 intron", "start": 4, "end": 20}, {"text": "rrn26", "start": 49, "end": 54}, {"text": "cox3", "start": 59, "end": 63}, {"text": "Marchantia rps10 gene", "start": 114, "end": 135}]}}, "schema": []}
{"input": "Serum magnesium in 79 patients of gynecologic neoplasms treated with cisplatin and their controls was measured.", "output": {"entities": {}}, "schema": []}
{"input": "Alanine aminotransferase (ALT) levels had been elevated for six months in all patients and hepatitis B viral infection was replicative.", "output": {"entities": {"gene": [{"text": "Alanine aminotransferase", "start": 0, "end": 24}, {"text": "ALT", "start": 26, "end": 29}]}}, "schema": []}
{"input": "In this study we have investigated the role of C/EBP beta in initiating the adipogenic program by overexpressing C/EBP beta in multipotential NIH-3T3 fibroblasts.", "output": {"entities": {"gene": [{"text": "C/EBP beta", "start": 47, "end": 57}, {"text": "C/EBP beta", "start": 113, "end": 123}]}}, "schema": []}
{"input": "XYL1 was isolated as a highly expressed fusion clone from a' lacZ translational fusion library.", "output": {"entities": {"gene": [{"text": "XYL1", "start": 0, "end": 4}, {"text": "' lacZ", "start": 59, "end": 65}]}}, "schema": []}
{"input": "Various transcripts are generated from the VCSA1 gene by alternative splicing and poly (A) processing in the rat submandibular gland.", "output": {"entities": {"gene": [{"text": "VCSA1 gene", "start": 43, "end": 53}]}}, "schema": []}
{"input": "However, division of the chest wall muscles, usually with diathermy, contributes to prolonged pain and morbidity.", "output": {"entities": {}}, "schema": []}
{"input": "Closure of an open high below-knee guillotine amputation wound using a skin-stretching device.", "output": {"entities": {}}, "schema": []}
{"input": "Our study was addressed to the synthesis of some derivatives of this sequence in order to obtain both peptide substrates suitable for the detection of the Src-like tyrosine kinase activity and active site-directed inhibitors specific for this class of enzymes.", "output": {"entities": {"gene": [{"text": "Src", "start": 155, "end": 158}, {"text": "tyrosine kinase", "start": 164, "end": 179}]}}, "schema": []}
{"input": "Citrate synthase activity was increased in the medial head (81%, P < 0. 001) and the red long head (88%, P < 0. 001) of the triceps brachii muscle in R rats but not in the white long head (25%, P = 0. 06).", "output": {"entities": {"gene": [{"text": "Citrate synthase", "start": 0, "end": 16}]}}, "schema": []}
{"input": "The expression of the putative operon bglPH of Bacillus subtilis was studied by using bglP'-lacZ transcriptional fusions.", "output": {"entities": {"gene": [{"text": "bglPH", "start": 38, "end": 43}, {"text": "bglP'", "start": 86, "end": 91}, {"text": "lacZ", "start": 92, "end": 96}]}}, "schema": []}
{"input": "Although eight contiguous genes necessary for urease activity have been cloned and sequenced, the transcriptional organization and regulation of specific genes within the Proteus gene cluster has not been investigated in detail.", "output": {"entities": {"gene": [{"text": "urease", "start": 46, "end": 52}, {"text": "Proteus gene cluster", "start": 171, "end": 191}]}}, "schema": []}
{"input": "The hypBFCDE operon from Rhizobium leguminosarum biovar viciae is expressed from an Fnr-type promoter that escapes mutagenesis of the fnrN gene.", "output": {"entities": {"gene": [{"text": "hypBFCDE operon", "start": 4, "end": 19}, {"text": "Fnr-type promoter", "start": 84, "end": 101}, {"text": "fnrN gene", "start": 134, "end": 143}]}}, "schema": []}
{"input": "We demonstrate that a VT + peptide was specifically phosphorylated by protein kinase C (PKC) in vitro, but not by protein kinase A (PKA).", "output": {"entities": {"gene": [{"text": "protein kinase C", "start": 70, "end": 86}, {"text": "PKC", "start": 88, "end": 91}, {"text": "protein kinase A", "start": 114, "end": 130}, {"text": "PKA", "start": 132, "end": 135}]}}, "schema": []}
{"input": "R.", "output": {"entities": {}}, "schema": []}
{"input": "15, 2500-2508; O' Neill, T.", "output": {"entities": {}}, "schema": []}
{"input": "Control experiments showed that each fusion protein had a high affinity binding site for estradiol-17 beta and could transactivate an ERE-LacZ reporter gene in yeast similar to the wild type ER.", "output": {"entities": {"gene": [{"text": "LacZ", "start": 138, "end": 142}, {"text": "wild type ER", "start": 181, "end": 193}]}}, "schema": []}
{"input": "Although Micrococcus luteus UV endonuclease has been reported to be an 18-kDa enzyme with possible homology to the 16-kDa endonuclease V from bacteriophage T4 (Gordon, L.", "output": {"entities": {"gene": [{"text": "Micrococcus luteus UV endonuclease", "start": 9, "end": 43}, {"text": "16-kDa endonuclease V from bacteriophage T4", "start": 115, "end": 158}]}}, "schema": []}
{"input": "Several different oncogenes and growth factors promote G1 phase progression.", "output": {"entities": {}}, "schema": []}
{"input": "Cyclin D1 promoter activity was stimulated by overexpression of mitogen-activated protein kinase (p41MAPK) or c-Ets-2 through the proximal 22 base pairs.", "output": {"entities": {"gene": [{"text": "Cyclin D1 promoter", "start": 0, "end": 18}, {"text": "mitogen-activated protein kinase", "start": 64, "end": 96}, {"text": "p41MAPK", "start": 98, "end": 105}, {"text": "c-Ets-2", "start": 110, "end": 117}]}}, "schema": []}
{"input": "Indeed, ERM and c-Jun synergistically activated the EBS-CRE without making an apparent ternary complex.", "output": {"entities": {"gene": [{"text": "ERM", "start": 8, "end": 11}, {"text": "c-Jun", "start": 16, "end": 21}]}}, "schema": []}
{"input": "In addition, the R206S HSF substitution exhibits constitutive transcriptional activation from a consensus HSE (HSE2).", "output": {"entities": {"gene": [{"text": "R206S HSF", "start": 17, "end": 26}]}}, "schema": []}
{"input": "After recovery, a hypertonic saline challenge was performed.", "output": {"entities": {}}, "schema": []}
{"input": "The range of eosinophils was 22-56% of the number of peripheral white blood cells (mean nadir 33%).", "output": {"entities": {}}, "schema": []}
{"input": "Comparisons of rrnB P1-lacZ expression at different ppGpp levels is interpreted for the rpoD (P504L) mutant as resulting from a hypersensitivity to ppGpp.", "output": {"entities": {"gene": [{"text": "rrnB P1", "start": 15, "end": 22}, {"text": "lacZ", "start": 23, "end": 27}, {"text": "rpoD (P504L) mutant", "start": 88, "end": 107}]}}, "schema": []}
{"input": "These intron chimeras show that peripheral sequences and the elements that define the splice sites are adequate for self-splicing activity but that the central portions containing the catalytic cores of ai4 and bi4 are deficient; these cores are the likely targets of the splicing proteins.", "output": {"entities": {"gene": [{"text": "ai4", "start": 203, "end": 206}, {"text": "bi4", "start": 211, "end": 214}]}}, "schema": []}
{"input": "Here we demonstrate genetically that plus-strand DNA synthesis of the yeast Ty1 element is initiated at two sites located at the 5' boundary of the 3' long terminal repeat (PPT1) and near the middle of the pol gene in the integrase coding sequence (PPT2).", "output": {"entities": {"gene": [{"text": "yeast Ty1 element", "start": 70, "end": 87}, {"text": "PPT1", "start": 173, "end": 177}, {"text": "pol gene", "start": 206, "end": 214}, {"text": "integrase coding sequence", "start": 222, "end": 247}, {"text": "PPT2", "start": 249, "end": 253}]}}, "schema": []}
{"input": "Characterization of the 3' ends of the plus-strand DNA fragments reveals (1) that the upstream fragment is elongated beyond PPT2 creating a plus-strand overlap and (2) that the majority of plus-strand strong-stop DNA fragments bear a copy of the minus-strand primer binding site in agreement with the accepted model of retroviral genomic RNA reverse transcription.", "output": {"entities": {"gene": [{"text": "PPT2", "start": 124, "end": 128}]}}, "schema": []}
{"input": "The patients undergoing VTLB had significantly shorter operative times (VTLB, 100. 2 +/-27. 2 min. vs OLB, 119. 8 +/-42. 6 min; p < 0. 01) and less blood loss (VTLB, 4. 7 +/-14. 6 ml vs OLB, 65. 7 +/-77. 0 ml; p < 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "By 150 minutes after Cr2O3 inhalation, FEV1. 0 had decreased by 32%.", "output": {"entities": {}}, "schema": []}
{"input": "This combined intravenous anaesthetic regimen gave good anaesthesia and analgesia to pigs for up to 2 h as monitored by clinical signs.", "output": {"entities": {}}, "schema": []}
{"input": "Twenty food products were contaminated with V. cholerae O1, Ogawa, toxigenic and not toxigenic strains: yoghurt, cream cheese, apricot marmelade, hip rose marmelade, mayonnaise, italian pasta for \" empanadas \", \" dulce de leche \", meat sausage, meat and spinach ravioli, margarine, milk dessert (made with cocoa, milk confiture, starch and additives), lettuce, tuna fish, ricotta and sterilized milk.", "output": {"entities": {}}, "schema": []}
{"input": "It is impossible to define only one clinical outline because both symptomatic and asymptomatic infected NB may be found with gestational age at term and pre-term and when born with a weight above or below 2000 g.", "output": {"entities": {}}, "schema": []}
{"input": "The expression of the pilin gene, tcpA, is dependent upon ToxR and upon ToxT.", "output": {"entities": {"gene": [{"text": "pilin gene", "start": 22, "end": 32}, {"text": "tcpA", "start": 34, "end": 38}, {"text": "ToxR", "start": 58, "end": 62}, {"text": "ToxT", "start": 72, "end": 76}]}}, "schema": []}
{"input": "Ras p21Val inhibits myogenesis without altering the DNA binding or transcriptional activities of the myogenic basic helix-loop-helix factors.", "output": {"entities": {"gene": [{"text": "Ras p21Val", "start": 0, "end": 10}, {"text": "myogenic basic helix-loop-helix factors", "start": 101, "end": 140}]}}, "schema": []}
{"input": "In cells limited for His, increased expression of arg-2 and cpc-1, and decreased expression of cox-5, also had translational and transcriptional components.", "output": {"entities": {"gene": [{"text": "arg-2", "start": 50, "end": 55}, {"text": "cpc-1", "start": 60, "end": 65}, {"text": "cox-5", "start": 95, "end": 100}]}}, "schema": []}
{"input": "The peptide sequences reveal that the factor consists of GABP alpha and GABP beta 1 with Ets and Notch motifs, respectively.", "output": {"entities": {"gene": [{"text": "GABP alpha", "start": 57, "end": 67}, {"text": "GABP beta 1", "start": 72, "end": 83}, {"text": "Ets", "start": 89, "end": 92}, {"text": "Notch motifs", "start": 97, "end": 109}]}}, "schema": []}
{"input": "Immunofluorescence microscopy and cell fractionation analyses showed that the 110-kDa protein was exclusively nuclear, whereas the 150-kDa protein was present in both the cytoplasm and nucleus of human cells.", "output": {"entities": {}}, "schema": []}
{"input": "Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase.", "output": {"entities": {"gene": [{"text": "interferon", "start": 29, "end": 39}, {"text": "double-stranded-RNA-specific adenosine deaminase", "start": 45, "end": 93}]}}, "schema": []}
{"input": "T-cell hybridomas, thymocytes, and T cells can be induced to undergo apoptotic cell death by activation through the T-cell receptor.", "output": {"entities": {"gene": [{"text": "T-cell receptor", "start": 116, "end": 131}]}}, "schema": []}
{"input": "Deletions were examined in the LYS2 gene, using a set of 31-to 156-bp inserts that included inserts with no apparent potential for secondary structure as well as two quasipalindromes.", "output": {"entities": {"gene": [{"text": "LYS2 gene", "start": 31, "end": 40}]}}, "schema": []}
{"input": "Overexpression of SCS1 could not complement an HSP60-null allele, indicating that suppression was not due to the bypassing of Hsp60 activity.", "output": {"entities": {"gene": [{"text": "SCS1", "start": 18, "end": 22}, {"text": "HSP60-null allele", "start": 47, "end": 64}, {"text": "Hsp60", "start": 126, "end": 131}]}}, "schema": []}
{"input": "The DNA binding domain of NirA was expressed as a fusion protein with the glutathione S-transferase of Schistosoma japonicum.", "output": {"entities": {"gene": [{"text": "NirA", "start": 26, "end": 30}, {"text": "glutathione S-transferase", "start": 74, "end": 99}]}}, "schema": []}
{"input": "The kinase is essential in vivo for normal phosphorylation of the CTD and for normal growth and differentiation.", "output": {"entities": {}}, "schema": []}
{"input": "Finally, we demonstrate that C/EBP alpha can also active the GM-CSF receptor alpha promoter in nonmyeloid cells.", "output": {"entities": {"gene": [{"text": "C/EBP alpha", "start": 29, "end": 40}, {"text": "GM-CSF receptor alpha", "start": 61, "end": 82}]}}, "schema": []}
{"input": "Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "Pdr5 ATP-binding cassette multidrug transporter", "start": 70, "end": 117}]}}, "schema": []}
{"input": "Disruption of the HOG1 and PBS2 genes leads to a dramatic decrease of the HSP12 inducibility in osmostressed cells, whereas overproduction of Hog1 produces a fivefold increase in wild-type induced levels upon a shift to a high salt concentration.", "output": {"entities": {"gene": [{"text": "HOG1", "start": 18, "end": 22}, {"text": "PBS2 genes", "start": 27, "end": 37}, {"text": "HSP12", "start": 74, "end": 79}, {"text": "Hog1", "start": 142, "end": 146}]}}, "schema": []}
{"input": "Deletion or inactivation of CRY1 leads to 5-to 10-fold-increased levels of CRY2 mRNA.", "output": {"entities": {"gene": [{"text": "CRY1", "start": 28, "end": 32}, {"text": "CRY2 mRNA", "start": 75, "end": 84}]}}, "schema": []}
{"input": "(1986) method of separation of Cryptosporidium spp. oocysts from feces by using a percoll discontinuous density gradient appeared a method of choice for obtaining large numbers of oocysts of C. parvum free of fecal contamination.", "output": {"entities": {}}, "schema": []}
{"input": "METHODS: We obtained maximal inspiratory and expiratory flow-volume curves in 41 unselected patients with essential tremor (14 males, 27 females, age 61. 7 +/-2. 14 years).", "output": {"entities": {}}, "schema": []}
{"input": "Our findings also provide the basis for the development of assays to screen for the ligands to testis receptor 2 and hERR1.", "output": {"entities": {"gene": [{"text": "testis receptor 2", "start": 95, "end": 112}, {"text": "hERR1", "start": 117, "end": 122}]}}, "schema": []}
{"input": "Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.", "output": {"entities": {"gene": [{"text": "p53 DNA-binding domain peptides", "start": 5, "end": 36}, {"text": "p53-response elements", "start": 50, "end": 71}]}}, "schema": []}
{"input": "The Stat5b mRNA has a size of 5. 6 kb and encodes a protein of 786 amino acids.", "output": {"entities": {"gene": [{"text": "Stat5b mRNA", "start": 4, "end": 15}]}}, "schema": []}
{"input": "The hydropathy plot revealed a rather hydrophilic N-terminal region and the absence of a hydrophobic signal peptide.", "output": {"entities": {}}, "schema": []}
{"input": "This report focused on the relationship between Type A behavior and eight basic emotion dimensions.", "output": {"entities": {}}, "schema": []}
{"input": "All carcasses resulted in contamination with aerobic mesophilic bacteria in the range from 6 x 10 (3) to 1. 2 x 10 (6) CFU/ml liquid washed, and 94% them with sporulate bacteria, the threshold being under 100 CFU/ml (Figure 1).", "output": {"entities": {}}, "schema": []}
{"input": "As for 31 stage I-II lung cancer patients, CR has been observed in 82. 8% of them and PR in 13. 8%; the response was always assessed with chest radiography, CT, FBS, cytology and/or histology.", "output": {"entities": {}}, "schema": []}
{"input": "Pediatric medical emergencies in a regional hospital: appropriate locale?", "output": {"entities": {}}, "schema": []}
{"input": "Protein electrophoresis showed decreased albumin levels in both groups, with lower values in G2.", "output": {"entities": {"gene": [{"text": "albumin", "start": 41, "end": 48}]}}, "schema": []}
{"input": "METHODS: All these 30 non-responders received an extra dose of the same vaccine 2 months after primary immunization and a booster dose with a yeast-derived vaccine 6 years later.", "output": {"entities": {}}, "schema": []}
{"input": "An abnormally high percentage of hypertensive patients (approximately 30%) undergoing cardiac catheterization because of anginal pain and/or exercise-induced ST-segment depressions has angiographically normal coronary arteries.", "output": {"entities": {}}, "schema": []}
{"input": "Mibefradil (Ro 40-5967) is a novel calcium antagonist from a new chemical class and is the first that selectively blocks the T-type calcium channel.", "output": {"entities": {}}, "schema": []}
{"input": "However, 2 minimum alveolar concentration anesthesia did significantly decrease the calculated VE at a PCO2 of 60 mmHg (from 7. 4 +/-1. 2 to 4. 0 +/-0. 6 l. min-1), indicating a rightward shift in the response relationship.", "output": {"entities": {}}, "schema": []}
{"input": "cDNA encoding a functional feline liver/bone/kidney-type alkaline phosphatase.", "output": {"entities": {"gene": [{"text": "feline liver/bone/kidney-type alkaline phosphatase", "start": 27, "end": 77}]}}, "schema": []}
{"input": "Protein kinase C (PKC), a widely-distributed enzyme implicated in the regulation of many physiological processes, consists of a family of at least twelve isoenzymes which differ in tissue distribution, subcellular localization, regulatory properties, etc.", "output": {"entities": {"gene": [{"text": "Protein kinase C", "start": 0, "end": 16}, {"text": "PKC", "start": 18, "end": 21}]}}, "schema": []}
{"input": "This work, therefore, also emphasizes the importance of careful choice of oligonucleotide and cDNA probes to study PKC zeta mRNA.", "output": {"entities": {"gene": [{"text": "PKC zeta mRNA", "start": 115, "end": 128}]}}, "schema": []}
{"input": "This action is dependent on helix-loop-helix factors bound to the E1 element.", "output": {"entities": {"gene": [{"text": "helix-loop-helix factors", "start": 28, "end": 52}, {"text": "E1", "start": 66, "end": 68}]}}, "schema": []}
{"input": "The debate over electives--1899.", "output": {"entities": {}}, "schema": []}
{"input": "Polypeptide growth factors and cytokines mediate their biochemical functions through their responsive receptors.", "output": {"entities": {}}, "schema": []}
{"input": "However, a strongly increased frequency of CpG dinucleotides was found.", "output": {"entities": {}}, "schema": []}
{"input": "During the dose-finding, two patients were temporarily withdrawn from medication and one patient was excluded because of elevated levels of liver enzymes.", "output": {"entities": {}}, "schema": []}
{"input": "In comparison of cDNA and genomic sequences four RNA editing events were found in both atp9 genes.", "output": {"entities": {"gene": [{"text": "atp9 genes", "start": 87, "end": 97}]}}, "schema": []}
{"input": "MZF-1 represses CAT reporter gene expression via GAL4 binding sites in the nonhematopoietic cell lines NIH 3T3 and 293.", "output": {"entities": {"gene": [{"text": "MZF-1", "start": 0, "end": 5}, {"text": "CAT reporter gene", "start": 16, "end": 33}, {"text": "GAL4 binding sites", "start": 49, "end": 67}]}}, "schema": []}
{"input": "As with the heterologous DNA binding domain, MZF-1 represses reporter gene expression in nonhematopoietic cell lines and activates expression in hematopoietic cell lines.", "output": {"entities": {"gene": [{"text": "MZF-1", "start": 45, "end": 50}]}}, "schema": []}
{"input": "Analyses of hGMR beta subunit mutants revealed two cytoplasmic regions involved in activation of the c-myc promoter, one is essential and the other is dispensable but enhances the activity.", "output": {"entities": {"gene": [{"text": "hGMR beta subunit mutants", "start": 12, "end": 37}, {"text": "c-myc promoter", "start": 101, "end": 115}]}}, "schema": []}
{"input": "Similarly, we observed synthetic phenotypes between mutations in MIF2 and trans-acting mutations in three known yeast centromere protein genes-CEP1/CBF1/CPF1, NDC10/CBF2, and CEP3/CBF3B.", "output": {"entities": {"gene": [{"text": "MIF2", "start": 65, "end": 69}, {"text": "CEP1", "start": 143, "end": 147}, {"text": "CBF1", "start": 148, "end": 152}, {"text": "CPF1", "start": 153, "end": 157}, {"text": "NDC10", "start": 159, "end": 164}, {"text": "CBF2", "start": 165, "end": 169}, {"text": "CEP3", "start": 175, "end": 179}, {"text": "CBF3B", "start": 180, "end": 185}]}}, "schema": []}
{"input": "Taken together, these data suggest that the Mif2 protein interacts with Cep1p at the centromere and that the yeast centromere indeed exists as a higher order protein-DNA complex.", "output": {"entities": {"gene": [{"text": "Mif2 protein", "start": 44, "end": 56}, {"text": "Cep1p", "start": 72, "end": 77}]}}, "schema": []}
{"input": "To accomplish this, actin cables and patches are redistributed during the cell cycle to direct secretory components to appropriate sites for cell growth.", "output": {"entities": {"gene": [{"text": "actin", "start": 20, "end": 25}]}}, "schema": []}
{"input": "The effects of Codonopsis pilosula oral liquor (CPOL) on tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) in the plasma of 25 patients of coronary heart disease with blood stasis were studied.", "output": {"entities": {"gene": [{"text": "tissue-type plasminogen activator", "start": 57, "end": 90}, {"text": "t-PA", "start": 92, "end": 96}, {"text": "plasminogen activator inhibitor", "start": 102, "end": 133}, {"text": "PAI", "start": 135, "end": 138}]}}, "schema": []}
{"input": "Estimated daily intakes (EDIs) per person were 0. 56 microgram for total HCH, 0. 20 microgram for gamma-HCH, 0. 09 microgram for dieldrin, 1. 42 micrograms for total DDT, and 0. 15 microgram for HCB.", "output": {"entities": {}}, "schema": []}
{"input": "In two further cases (one type I and one type III SMA), de novo deletions of only one copy of Ag1-CA and C212 were found.", "output": {"entities": {"gene": [{"text": "Ag1-CA", "start": 94, "end": 100}, {"text": "C212", "start": 105, "end": 109}]}}, "schema": []}
{"input": "With each of the three pairs of isolates (case and suspicious case), identical IS6110 banding patterns were found suggesting identical MTB strains.", "output": {"entities": {}}, "schema": []}
{"input": "HRES has been found to be clinically useful in assessing histologic damage following pneumatic dilatation and in localizing the LES during the administration of intrasphincter botulinum toxin injection in the treatment of achalasia.", "output": {"entities": {"gene": [{"text": "botulinum toxin", "start": 176, "end": 191}]}}, "schema": []}
{"input": "These early structural processes are assumed to be subserved by the anterior parts of the left hemisphere, as event-related brain potentials show this area to be maximally activated when phrase structure violations are processed and as circumscribed lesions in this area lead to an impairment of the on-line structural assignment.", "output": {"entities": {}}, "schema": []}
{"input": "In men with BMI < 30, the OR was 1. 83 for postprandial TG (P =. 041) and 2. 77 for postprandial RP (P =. 032) in models that included fasting TG, LDL-C, and hypertension.", "output": {"entities": {"gene": [{"text": "LDL-C", "start": 147, "end": 152}]}}, "schema": []}
{"input": "A pyrazolo-quinoline compound, 6-methoxy-4-[2-[(2-hydroxyethoxyl)-ethyl] amino]-3-methyl-1M-pyrazo lo [3, 4-b] quinoline (SCH 51344), was identified based on its ability to derepress human smooth muscle alpha-actin promoter activity in ras-transformed cells.", "output": {"entities": {"gene": [{"text": "alpha-actin promoter", "start": 203, "end": 223}, {"text": "ras", "start": 236, "end": 239}]}}, "schema": []}
{"input": "On the basis of these relations, a risk factor-selection scale (RFSS) (range, 0 to 10) was developed by computing appropriate weights for each risk factor.", "output": {"entities": {}}, "schema": []}
{"input": "The Caenorhabditis elegans death susceptibility gene, ced-3, has a number of homologs in vertebrate species, including interleukin-1 beta (IL-1 beta)-converting enzyme (ICE), Ich-1long, and CPP32.", "output": {"entities": {"gene": [{"text": "Caenorhabditis elegans death susceptibility gene", "start": 4, "end": 52}, {"text": "ced-3", "start": 54, "end": 59}, {"text": "interleukin-1 beta (IL-1 beta)-converting enzyme", "start": 119, "end": 167}, {"text": "ICE", "start": 169, "end": 172}, {"text": "Ich-1long", "start": 175, "end": 184}, {"text": "CPP32", "start": 190, "end": 195}]}}, "schema": []}
{"input": "Repression of glucocorticoid receptor-mediated transcriptional activation by unliganded thyroid hormone receptor (TR) is TR isoform-specific.", "output": {"entities": {"gene": [{"text": "glucocorticoid receptor", "start": 14, "end": 37}, {"text": "thyroid hormone receptor", "start": 88, "end": 112}, {"text": "TR", "start": 114, "end": 116}, {"text": "TR", "start": 121, "end": 123}]}}, "schema": []}
{"input": "The results indicate considerable flexibility in the spacing between DH regulatory sites.", "output": {"entities": {"gene": [{"text": "DH", "start": 69, "end": 71}]}}, "schema": []}
{"input": "Obstruction of the ERF repressor function by the transactivating members of the ets family of genes (i. e. gag-myb-ets) may be essential for the control of genes involved in cell proliferation and may also underlie their tumorigenic effects.", "output": {"entities": {"gene": [{"text": "ERF repressor", "start": 19, "end": 32}, {"text": "ets family", "start": 80, "end": 90}, {"text": "gag", "start": 107, "end": 110}, {"text": "myb", "start": 111, "end": 114}, {"text": "ets", "start": 115, "end": 118}]}}, "schema": []}
{"input": "We show that c-Fos (the c-fos protooncogene product), which is an intrinsically unstable nuclear protein, is metabolically highly stabilized, and greatly enhances the transforming efficiency of NIH 3T3 cells, by Mos.", "output": {"entities": {"gene": [{"text": "c-Fos", "start": 13, "end": 18}, {"text": "c-fos protooncogene product", "start": 24, "end": 51}, {"text": "Mos", "start": 212, "end": 215}]}}, "schema": []}
{"input": "Cloning, sequencing and expression of the 3-phosphoglycerate kinase gene of Pyrococcus woesei in Escherichia coli and characterization of the protein.", "output": {"entities": {"gene": [{"text": "3-phosphoglycerate kinase gene", "start": 42, "end": 72}]}}, "schema": []}
{"input": "We sought to determine whether such differences in polyadenylation affect the steady-state levels of DHFR and mRNAs expressed from either allele and, in a more general sense, to ask whether differences in 3' end RNA processing in a gene containing multiple poly (A) sites affects the final level of gene expression.", "output": {"entities": {"gene": [{"text": "DHFR", "start": 101, "end": 105}]}}, "schema": []}
{"input": "The finding that the chimeric TdT:: Pol beta protein possessed significant template-dependent polymerase activity suggests that aa 1-60 of Pol beta are involved in template utilization during the polymerization reaction, as suggested by the previous finding that the 8-kDa N-terminal domain of Pol beta possesses ssDNA-binding activity [Kumar et al., J.", "output": {"entities": {"gene": [{"text": "chimeric TdT", "start": 21, "end": 33}, {"text": "Pol beta protein", "start": 36, "end": 52}, {"text": "Pol beta", "start": 139, "end": 147}, {"text": "Pol beta", "start": 294, "end": 302}]}}, "schema": []}
{"input": "The average values were 199 and 424 revertants/g for the hamburgers and hot dogs, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Cholangiography was performed in all cases and classified by a scoring system specifically developed for pediatric patients.", "output": {"entities": {}}, "schema": []}
{"input": "In Trial 1, eight sows were allowed to farrow naturally (d 114, NF sows) and eight sows were induced to farrow (IF sows) prematurely by injection of prostaglandin F2 alpha on d 112 of gestation.", "output": {"entities": {}}, "schema": []}
{"input": "End-tidal PO2 and the ratio of minute ventilation to oxygen consumption (VE/VO2) were lower while PETCO2 was higher for Hyp (P < or = 0. 01).", "output": {"entities": {}}, "schema": []}
{"input": "These results suggested that NfxB negatively autoregulates the expression of nfxB itself.", "output": {"entities": {"gene": [{"text": "NfxB", "start": 29, "end": 33}, {"text": "nfxB", "start": 77, "end": 81}]}}, "schema": []}
{"input": "A511 is a broad-host-range, virulent myovirus for Listeria monocytogenes.", "output": {"entities": {}}, "schema": []}
{"input": "The mechanism of peroxisome proliferation is poorly understood.", "output": {"entities": {}}, "schema": []}
{"input": "If NCR-sensitive gene expression occurs exclusively by this pathway, as has been thought to be the case, then the NCR sensitivity of a gene' s expression should be abolished by a ure2 delta mutation.", "output": {"entities": {"gene": [{"text": "ure2 delta mutation", "start": 179, "end": 198}]}}, "schema": []}
{"input": "The single-stranded DNA Pur alpha recognition element disrupts these complexes.", "output": {"entities": {"gene": [{"text": "Pur alpha recognition element", "start": 24, "end": 53}]}}, "schema": []}
{"input": "Association of human Pur alpha with the retinoblastoma protein, Rb, regulates binding to the single-stranded DNA Pur alpha recognition element.", "output": {"entities": {"gene": [{"text": "human Pur alpha", "start": 15, "end": 30}, {"text": "retinoblastoma protein", "start": 40, "end": 62}, {"text": "Rb", "start": 64, "end": 66}, {"text": "Pur alpha recognition element", "start": 113, "end": 142}]}}, "schema": []}
{"input": "The insulin-induced DNA-binding complex was identified as the p50/p65 heterodimer.", "output": {"entities": {"gene": [{"text": "insulin", "start": 4, "end": 11}, {"text": "p50", "start": 62, "end": 65}, {"text": "p65", "start": 66, "end": 69}]}}, "schema": []}
{"input": "Using varying conditions, three distinct complexes were shown to interact specifically with the NIP region, although only one correlates with repressor activity.", "output": {"entities": {"gene": [{"text": "NIP region", "start": 96, "end": 106}]}}, "schema": []}
{"input": "Exchange of the LPL and HL lids resulted in a reversal of the phospholipase/neutral lipase ratio, establishing the important role of this region in mediating substrate specificity.", "output": {"entities": {"gene": [{"text": "LPL", "start": 16, "end": 19}, {"text": "HL", "start": 24, "end": 26}, {"text": "phospholipase", "start": 62, "end": 75}, {"text": "lipase", "start": 84, "end": 90}]}}, "schema": []}
{"input": "The interferon-inducible protein kinase PKR modulates the transcriptional activation of immunoglobulin kappa gene.", "output": {"entities": {"gene": [{"text": "interferon", "start": 4, "end": 14}, {"text": "protein kinase PKR", "start": 25, "end": 43}, {"text": "immunoglobulin kappa gene", "start": 88, "end": 113}]}}, "schema": []}
{"input": "Truncated forms of a novel yeast protein suppress the lethality of a G protein alpha subunit deficiency by interacting with the beta subunit.", "output": {"entities": {"gene": [{"text": "G protein alpha subunit", "start": 69, "end": 92}]}}, "schema": []}
{"input": "Another common mutation involved amino acids that are thought to make specific contacts with DNA.", "output": {"entities": {}}, "schema": []}
{"input": "Levels of TSG-14 protein (also termed PTX-3) become elevated in the serum of mice and humans after injection with bacterial lipopolysaccharide, but in contrast to conventional acute phase proteins, the bulk of TSG-14 synthesis in the intact organism occurs outside the liver.", "output": {"entities": {"gene": [{"text": "TSG-14 protein", "start": 10, "end": 24}, {"text": "PTX-3", "start": 38, "end": 43}, {"text": "TSG-14", "start": 210, "end": 216}]}}, "schema": []}
{"input": "The mouse beta 2-syntrophin gene (> 33 kilobases) contains seven exons, all of which have homologues at the corresponding position in the alpha 1-syntrophin gene.", "output": {"entities": {"gene": [{"text": "mouse beta 2-syntrophin gene", "start": 4, "end": 32}, {"text": "alpha 1-syntrophin gene", "start": 138, "end": 161}]}}, "schema": []}
{"input": "Altogether our data indicate that PEDF belongs to the subgroup of noninhibitory serpins and that its N-terminal region confers a neurite-promoting activity to the protein.", "output": {"entities": {"gene": [{"text": "PEDF", "start": 34, "end": 38}, {"text": "serpins", "start": 80, "end": 87}]}}, "schema": []}
{"input": "We report here the cloning of the murine p44 MAP kinase (extracellular signal-regulated kinase 1) gene, the determination of its intron/exon boundaries, and the characterization of its promoter.", "output": {"entities": {"gene": [{"text": "p44 MAP kinase", "start": 41, "end": 55}, {"text": "extracellular signal-regulated kinase 1", "start": 57, "end": 96}]}}, "schema": []}
{"input": "It contains three putative TATA boxes far upstream of the main start sites region, one AP-1 box, one AP-2 box, one Malt box, one GAGA box, one half serum-responsive element, and putative binding sites for Sp1 (five), GC-rich binding factor (five), CTF-NF1 (one), Myb (one), p53 (two), Ets-1 (one), NF-IL6 (two), MyoD (two), Zeste (one), and hepatocyte nuclear factor-5 (one).", "output": {"entities": {"gene": [{"text": "AP-1 box", "start": 87, "end": 95}, {"text": "AP-2 box", "start": 101, "end": 109}, {"text": "Malt box", "start": 115, "end": 123}, {"text": "Sp1", "start": 205, "end": 208}, {"text": "GC-rich binding factor", "start": 217, "end": 239}, {"text": "CTF-NF1", "start": 248, "end": 255}, {"text": "Myb", "start": 263, "end": 266}, {"text": "p53", "start": 274, "end": 277}, {"text": "Ets-1", "start": 285, "end": 290}, {"text": "NF-IL6", "start": 298, "end": 304}, {"text": "MyoD", "start": 312, "end": 316}, {"text": "Zeste", "start": 324, "end": 329}, {"text": "hepatocyte nuclear factor-5", "start": 341, "end": 368}]}}, "schema": []}
{"input": "We conclude that this new measurement technique provides an easy and accurate P0. 1 measurement using standard respiratory equipment when tested in a lung model.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of verapamil and propranolol on early afterdepolarizations and ventricular arrhythmias induced by epinephrine in congenital long QT syndrome.", "output": {"entities": {}}, "schema": []}
{"input": "Deletion of the NF-IL6 beta leucine zipper domain also greatly diminished the interaction between these two proteins.", "output": {"entities": {"gene": [{"text": "NF-IL6 beta leucine zipper domain", "start": 16, "end": 49}]}}, "schema": []}
{"input": "After cells were stably transfected with CIITA, endogenous MHC class II genes were constitutively expressed, and MHC class II promoters, delivered by transfection, were actively transcribed in CIITA-expressing cells.", "output": {"entities": {"gene": [{"text": "CIITA", "start": 41, "end": 46}, {"text": "MHC class II genes", "start": 59, "end": 77}, {"text": "MHC class II promoters", "start": 113, "end": 135}, {"text": "CIITA", "start": 193, "end": 198}]}}, "schema": []}
{"input": "Two domains of EBNA2 defined by deletion of amino acids 247-337 and 437-476 were found to be important for the activation of both promoters, while two different domains corresponding to residues 4-18 and 118-198 were required solely for the LMP1 promoter.", "output": {"entities": {"gene": [{"text": "EBNA2", "start": 15, "end": 20}, {"text": "LMP1 promoter", "start": 241, "end": 254}]}}, "schema": []}
{"input": "The peak velocities of the atrial systolic waves of the transmitral and pulmonary venous flow velocities (A and PVA, respectively) and first systolic wave (PVS1) of pulmonary venous flow, durations of both atrial systolic waves, and amplitude of interatrial septal motion during atrial systole increased significantly ten days after cardioversion compared with those measured within a day of cardioversion in all patients except the 5 patients with dilated cardiomyopathy.", "output": {"entities": {}}, "schema": []}
{"input": "These results suggest that low concentrations of IL-1 beta may be useful for nonsurgical treatment of human vitreous hemorrhage.", "output": {"entities": {"gene": [{"text": "IL-1 beta", "start": 49, "end": 58}]}}, "schema": []}
{"input": "We conclude that pancreatic polypeptide and motilin responses to a meal are different in encopretic children than in children in the control group.", "output": {"entities": {"gene": [{"text": "motilin", "start": 44, "end": 51}]}}, "schema": []}
{"input": "Here we report the cloning, expression, and biochemical characterization of the 32-kDa subunit of human (h) TFIID, termed hTAFII32.", "output": {"entities": {"gene": [{"text": "TFIID", "start": 108, "end": 113}, {"text": "hTAFII32", "start": 122, "end": 130}]}}, "schema": []}
{"input": "Hemolytic jaundice due to G6PD deficiency causing kernicterus in a female newborn.", "output": {"entities": {"gene": [{"text": "G6PD", "start": 26, "end": 30}]}}, "schema": []}
{"input": "Two transcripts of 1. 6 kb and 5. 8 kb are 5' coterminal and may both encode the novel glycoprotein gene EUS4.", "output": {"entities": {"gene": [{"text": "glycoprotein gene EUS4", "start": 87, "end": 109}]}}, "schema": []}
{"input": "However, the few studies that address antimicrobial prophylaxis in bone marrow transplantation have not always shown a survival benefit.", "output": {"entities": {}}, "schema": []}
{"input": "The fracture groups were significantly older and had more years since menopause than the control groups.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, we found differences in the binding of nuclear factors from shoots versus from roots, in agreement with the different activities of the promoter in these two organs.", "output": {"entities": {}}, "schema": []}
{"input": "The prevalence and incidence of human immunodeficiency virus types 1 and 2 (HIV-1, HIV-2), human T-lymphotropic virus types I and II (HTLV-I/II), and syphilitic infections and the association between these infections were determined in a cohort of police officers in Guinea-Bissau.", "output": {"entities": {}}, "schema": []}
{"input": "We now show that the BAT1 translation product is the homolog of the rat p47 nuclear protein, the WM6 Drosophila gene product, and probably also Ce08102 of Caenorhabditis elegans, all members of the DEAD protein family of ATP-dependent RNA helicases.", "output": {"entities": {"gene": [{"text": "BAT1 translation product", "start": 21, "end": 45}, {"text": "rat p47 nuclear protein", "start": 68, "end": 91}, {"text": "WM6 Drosophila gene product", "start": 97, "end": 124}, {"text": "Ce08102", "start": 144, "end": 151}, {"text": "DEAD protein family", "start": 198, "end": 217}, {"text": "ATP-dependent RNA helicases", "start": 221, "end": 248}]}}, "schema": []}
{"input": "By using lacZ fusions, it was possible to localize the DNA sequences required to mediate nitrate repression to the pfl promoter-regulatory region.", "output": {"entities": {"gene": [{"text": "lacZ fusions", "start": 9, "end": 21}, {"text": "pfl promoter-regulatory region", "start": 115, "end": 145}]}}, "schema": []}
{"input": "In this report, we describe the characterization of two early class II flagellar genes contained in the orfX-fliP locus.", "output": {"entities": {"gene": [{"text": "class II flagellar genes", "start": 62, "end": 86}, {"text": "fliP", "start": 109, "end": 113}]}}, "schema": []}
{"input": "Vestibular adaptation exercises and recovery: acute stage after acoustic neuroma resection.", "output": {"entities": {}}, "schema": []}
{"input": "There were no significant changes in either the fatty acid composition of biliary lecithin or in the bile acid composition of bile.", "output": {"entities": {}}, "schema": []}
{"input": "Although further studies are required to determine the precise role of PEBP2 in the GM-CSF promoter activity, the present findings suggested the importance of the relative ratio of different PEBP2 isoforms in regulating the levels of the promoter activity.", "output": {"entities": {"gene": [{"text": "PEBP2", "start": 71, "end": 76}, {"text": "GM-CSF promoter", "start": 84, "end": 99}, {"text": "PEBP2 isoforms", "start": 191, "end": 205}]}}, "schema": []}
{"input": "Benefits of obtaining board certification in pharmacotherapy.", "output": {"entities": {}}, "schema": []}
{"input": "Basal plasma renin activity (PRA) was slightly raised prior to training (P < 0. 07) compared to the controls and post-training.", "output": {"entities": {"gene": [{"text": "renin", "start": 13, "end": 18}]}}, "schema": []}
{"input": "The structural gene encoding the novel lantibiotic epilancin K7 from Staphylococcus epidermidis K7 was cloned and its nucleotide sequence was determined.", "output": {"entities": {"gene": [{"text": "epilancin K7", "start": 51, "end": 63}]}}, "schema": []}
{"input": "The spectrum of phenotypes caused by these mutations was strikingly different than mutations in the adaptor for the VP16 activation domain.", "output": {"entities": {"gene": [{"text": "VP16 activation domain", "start": 116, "end": 138}]}}, "schema": []}
{"input": "The 5' flanking region is highly GC rich, with multiple CpG doublets, and contains multiple binding sites for Sp1.", "output": {"entities": {"gene": [{"text": "Sp1", "start": 110, "end": 113}]}}, "schema": []}
{"input": "To discern whether these disorders of GnRH deficiency are associated with altered melatonin secretion profiles, we compared untreated young males IGD (n = 7) and DP (n = 7) to normal pubertal male controls (n = 6).", "output": {"entities": {"gene": [{"text": "GnRH", "start": 38, "end": 42}]}}, "schema": []}
{"input": "Increased blood pressure during CyA treatment was independent of circulating ET-1 levels.", "output": {"entities": {"gene": [{"text": "ET-1", "start": 77, "end": 81}]}}, "schema": []}
{"input": "Analysis of several Tat mutants indicated that both the cysteine-rich and the core domains of this transactivator are necessary and sufficient to activate transcription when TBP is overexpressed.", "output": {"entities": {"gene": [{"text": "Tat mutants", "start": 20, "end": 31}, {"text": "TBP", "start": 174, "end": 177}]}}, "schema": []}
{"input": "In addition, depletion of Oct-1 from the nuclear extract by using Oct-1-specific antiserum or a sequence-specific DNA affinity resin decreased in vitro transcription from the wild-type MMTV promoter to a level identical to that obtained from a promoter in which all three octamer-related sequences were mutated.", "output": {"entities": {"gene": [{"text": "Oct-1", "start": 26, "end": 31}, {"text": "Oct-1", "start": 66, "end": 71}]}}, "schema": []}
{"input": "Transactivation of the HIV-1 LTR by T3R alpha and several receptor mutants revealed that the 50-amino-acid N-terminal A/B region of T3R alpha, known to interact with the basal transcription factor TFIIB, is critical for activation of both Tat-dependent and Tat-independent responsive sequences of the LTR.", "output": {"entities": {"gene": [{"text": "HIV-1 LTR", "start": 23, "end": 32}, {"text": "T3R alpha", "start": 36, "end": 45}, {"text": "T3R alpha", "start": 132, "end": 141}, {"text": "basal transcription factor TFIIB", "start": 170, "end": 202}, {"text": "Tat", "start": 239, "end": 242}, {"text": "Tat", "start": 257, "end": 260}]}}, "schema": []}
{"input": "M. M. C. was used for 2. 5 minutes in 44 cases (20 HR patients, 24 LR patients), and for 5 minutes in 66 cases (46 HR patients, 20 LR patients).", "output": {"entities": {}}, "schema": []}
{"input": "Finally, we show that complexes similar to the C25, C30 and C35 complexes are formed by rat cortex nuclear extracts and the SAA element in EMSA experiments, suggesting the relevance of our in vitro observations to the in vivo functioning of the rat APP promoter.", "output": {"entities": {"gene": [{"text": "C25", "start": 47, "end": 50}, {"text": "C30", "start": 52, "end": 55}, {"text": "C35 complexes", "start": 60, "end": 73}, {"text": "rat APP promoter", "start": 245, "end": 261}]}}, "schema": []}
{"input": "Oncological, clinical and psychological aspects are evaluated according to experience accumulated in recent years, with immediate and delayed reconstruction, carried out in the most diverse specialized centers.", "output": {"entities": {}}, "schema": []}
{"input": "The analysis of the prevalence values shows clearly that the global MS-frequency is closer related to the geomagnetic than to the geographic latitude.", "output": {"entities": {}}, "schema": []}
{"input": "Diltiazem caused significant decrease in the ventricular response without conversion to sinus rhythm.", "output": {"entities": {}}, "schema": []}
{"input": "Subhuman primates appear to be more sensitive to reproductive and other adverse effects of PCBs than humans.", "output": {"entities": {}}, "schema": []}
{"input": "When excluding children with ocular and cerebral pathology, 32 matched pairs of premature and control children remained.", "output": {"entities": {}}, "schema": []}
{"input": "The cryptococcal antigen test was positive at 1: 125 by latex agglutination.", "output": {"entities": {"gene": [{"text": "cryptococcal antigen", "start": 4, "end": 24}]}}, "schema": []}
{"input": "Functional analysis of DNase-I hypersensitive sites at the mouse porphobilinogen deaminase gene locus.", "output": {"entities": {"gene": [{"text": "DNase-I", "start": 23, "end": 30}, {"text": "mouse porphobilinogen deaminase gene locus", "start": 59, "end": 101}]}}, "schema": []}
{"input": "These transcripts have a unique 5' untranslated region and NH2-terminal sequence and encode a predicted protein of 121 kD.", "output": {"entities": {}}, "schema": []}
{"input": "Both mu and gamma 2b heavy chain genes cause this feedback inhibition of heavy chain gene rearrangement.", "output": {"entities": {"gene": [{"text": "mu and gamma 2b heavy chain genes", "start": 5, "end": 38}]}}, "schema": []}
{"input": "Purified CarP binds in vitro to the carAB control region and protects against DNase I two approximately 25 bp long stretches, one of which is located just downstream of the GATC sequence.", "output": {"entities": {"gene": [{"text": "CarP", "start": 9, "end": 13}, {"text": "carAB control region", "start": 36, "end": 56}, {"text": "DNase I", "start": 78, "end": 85}]}}, "schema": []}
{"input": "They include genes encoding three subunits of the cytochrome oxidase (cox1 to 3), apocytochrome b (cob), seven subunits of the NADH dehydrogenase complex (nad1 to 6, nad4L), two ATPase subunits (atp6 and atp9), three ribosomal RNAs (rrn5, srn and lrn), 23 tRNAs and four ribosomal proteins (rps3, rps11, rps12 and rpl16).", "output": {"entities": {"gene": [{"text": "cytochrome oxidase", "start": 50, "end": 68}, {"text": "cox1 to 3", "start": 70, "end": 79}, {"text": "apocytochrome b", "start": 82, "end": 97}, {"text": "cob", "start": 99, "end": 102}, {"text": "NADH dehydrogenase complex", "start": 127, "end": 153}, {"text": "nad1 to 6", "start": 155, "end": 164}, {"text": "nad4L", "start": 166, "end": 171}, {"text": "ATPase", "start": 178, "end": 184}, {"text": "atp6", "start": 195, "end": 199}, {"text": "atp9", "start": 204, "end": 208}, {"text": "rrn5", "start": 233, "end": 237}, {"text": "srn", "start": 239, "end": 242}, {"text": "lrn", "start": 247, "end": 250}, {"text": "rps3", "start": 291, "end": 295}, {"text": "rps11", "start": 297, "end": 302}, {"text": "rps12", "start": 304, "end": 309}, {"text": "rpl16", "start": 314, "end": 319}]}}, "schema": []}
{"input": "From day 10, a significant increase in platelet count was observed in eight of the ten patients treated with heparin (p < 0. 05), with return to the initial value after heparin cessation in six of the responders.", "output": {"entities": {}}, "schema": []}
{"input": "These \" nucleocapsid-like \" structures were readily purified by density gradient centrifugation.", "output": {"entities": {}}, "schema": []}
{"input": "Resources for helping patients to quit smoking.", "output": {"entities": {}}, "schema": []}
{"input": "The PEBP2 alpha proteins contain a 128-amino-acid (aa) region highly homologous to the Drosophila melanogaster segmentation gene runt.", "output": {"entities": {"gene": [{"text": "PEBP2 alpha proteins", "start": 4, "end": 24}, {"text": "Drosophila melanogaster segmentation gene runt", "start": 87, "end": 133}]}}, "schema": []}
{"input": "In human proliferative cells, the NADP-dependent ME activity is poorly expressed and barely inducible by thyroid hormones.", "output": {"entities": {"gene": [{"text": "ME", "start": 49, "end": 51}]}}, "schema": []}
{"input": "Based on previous mapping of the G beta gamma binding region of beta ARK, and conserved residues within the PH domain, we have constructed a series of mutants in the carboxyl terminus of beta ARK in order to determine important residues involved in G beta gamma and PIP2 binding.", "output": {"entities": {"gene": [{"text": "G beta gamma binding region", "start": 33, "end": 60}, {"text": "beta ARK", "start": 64, "end": 72}, {"text": "PH domain", "start": 108, "end": 117}, {"text": "beta ARK", "start": 187, "end": 195}, {"text": "G beta gamma", "start": 249, "end": 261}]}}, "schema": []}
{"input": "To dissect these mechanisms, wild-type and mutant Raf-1 proteins were studied in an in vitro system with purified plasma membranes from v-Ras-and v-Src-transformed cells (transformed membranes).", "output": {"entities": {"gene": [{"text": "mutant Raf-1 proteins", "start": 43, "end": 64}, {"text": "v-Ras", "start": 136, "end": 141}, {"text": "v-Src", "start": 146, "end": 151}]}}, "schema": []}
{"input": "In CV-1 cells, cotransfection of the retinoid and estrogen receptors led to mutual inhibition of the other' s activity, while an RA-dependent inhibition of ER activity was observed in breast cancer cells.", "output": {"entities": {"gene": [{"text": "retinoid and estrogen receptors", "start": 37, "end": 68}, {"text": "ER", "start": 156, "end": 158}]}}, "schema": []}
{"input": "D.", "output": {"entities": {}}, "schema": []}
{"input": "It was proposed that the synthetase-related sequences of GCN2 stimulate the activity of the kinase by interacting directly with uncharged tRNA that accumulates during amino acid limitation.", "output": {"entities": {"gene": [{"text": "GCN2", "start": 57, "end": 61}]}}, "schema": []}
{"input": "However, unlike Bcl-2 and the E1B 19K proteins, which completely block apoptosis but not p53-dependent growth arrest, H-ras expression permitted DNA synthesis and cell proliferation in the presence of high levels of wild-type p53.", "output": {"entities": {"gene": [{"text": "Bcl-2", "start": 16, "end": 21}, {"text": "E1B 19K proteins", "start": 30, "end": 46}, {"text": "p53", "start": 89, "end": 92}, {"text": "H-ras", "start": 118, "end": 123}, {"text": "wild-type p53", "start": 216, "end": 229}]}}, "schema": []}
{"input": "To compare the PAX3 and putative PAX3-FKHR transactivation domains, we fused C-terminal test fragments to the heterologous GAL4 DNA-binding domain and tested activation of a reporter gene co-transfected into four cell types.", "output": {"entities": {"gene": [{"text": "PAX3", "start": 15, "end": 19}, {"text": "PAX3", "start": 33, "end": 37}, {"text": "FKHR", "start": 38, "end": 42}, {"text": "GAL4 DNA-binding domain", "start": 123, "end": 146}]}}, "schema": []}
{"input": "All subjects were submitted to ECG and arterial blood pressure determination and were assayed for TSH, thyroid hormone, PRL, glucose, creatinine, nitrogen, glutamine transaminase, cholesterol and triglycerides plasma levels before therapy (T0), after 30 treatment days (T30) and after a 15 days washout (T45).", "output": {"entities": {"gene": [{"text": "TSH", "start": 98, "end": 101}, {"text": "PRL", "start": 120, "end": 123}, {"text": "glutamine transaminase", "start": 156, "end": 178}]}}, "schema": []}
{"input": "Acute decrease in body temperature (TB) lowered PaCO2 (32. 5 to 14. 5 mmHg) and [HCO3-] a (24. 20 mEq/L to 17. 56 mEq/L), increased pHa (7. 481 to 7. 608) and diminished the [OH-]/[H +] ratio, but had no significant effect on [SID] or [Atot], although both total phosphorus [PT] and inorganic phosphate [Pi] increased.", "output": {"entities": {}}, "schema": []}
{"input": "Hepatitis B vaccine: still has its problems.", "output": {"entities": {}}, "schema": []}
{"input": "Basal promoter activity is enhanced by a functional M1 domain in LHR-expressing mouse Leydig tumor cells (MLTC) but not in non-expressing CHO cells.", "output": {"entities": {"gene": [{"text": "LHR", "start": 65, "end": 68}]}}, "schema": []}
{"input": "For Al, the exposure to 1. 36 mg/m3 during the shift corresponded to a urinary concentration at the end of the shift of 200 microgram/g creatinine.", "output": {"entities": {}}, "schema": []}
{"input": "Tumor necrosis factor-alpha (TNF alpha), a proinflammatory cytokine, inhibits cAMP-stimulated testosterone production in mouse Leydig cells.", "output": {"entities": {"gene": [{"text": "Tumor necrosis factor-alpha", "start": 0, "end": 27}, {"text": "TNF alpha", "start": 29, "end": 38}]}}, "schema": []}
{"input": "The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential.", "output": {"entities": {"gene": [{"text": "Drosophila insulin receptor homolog", "start": 4, "end": 39}]}}, "schema": []}
{"input": "We show here that RA and E1A induce phosphorylation of the E1A-associated 300 kDa protein (p300) during the differentiation of F9 cells.", "output": {"entities": {"gene": [{"text": "E1A", "start": 25, "end": 28}, {"text": "E1A-associated 300 kDa protein", "start": 59, "end": 89}, {"text": "p300", "start": 91, "end": 95}]}}, "schema": []}
{"input": "The double-stranded RNA binding domain (dsRBD) is an approximately 65 amino acid motif that is found in a variety of proteins that interact with double-stranded (ds) RNA, such as Escherichia coli RNase III and the dsRNA-dependent kinase, PKR.", "output": {"entities": {"gene": [{"text": "RNase III", "start": 196, "end": 205}, {"text": "dsRNA-dependent kinase", "start": 214, "end": 236}, {"text": "PKR", "start": 238, "end": 241}]}}, "schema": []}
{"input": "SCA was resistant to inhibitors of serine, aspartyl, and metalloproteases, but it was sensitive to N-ethylmaleimide.", "output": {"entities": {"gene": [{"text": "SCA", "start": 0, "end": 3}, {"text": "metalloproteases", "start": 57, "end": 73}]}}, "schema": []}
{"input": "Mutational analysis of potential activating phosphorylation sites found in NIMA, NIM-1, and related protein kinases was performed on NIMA.", "output": {"entities": {"gene": [{"text": "NIMA", "start": 75, "end": 79}, {"text": "NIM-1", "start": 81, "end": 86}, {"text": "NIMA", "start": 133, "end": 137}]}}, "schema": []}
{"input": "However, a similar mutation of a leucine residue to arginine at position 422 showed no alteration of heterodimerization, DNA binding, or transcriptional activation.", "output": {"entities": {}}, "schema": []}
{"input": "Expression of the CYP11A1 gene is increased by hormones, such as adrenocorticotropin and luteinizing hormone, as well as by a number of growth factors, suggesting that its promoter may contain regulatory elements that respond to multiple signal transduction pathways.", "output": {"entities": {"gene": [{"text": "CYP11A1 gene", "start": 18, "end": 30}, {"text": "adrenocorticotropin", "start": 65, "end": 84}, {"text": "luteinizing hormone", "start": 89, "end": 108}]}}, "schema": []}
{"input": "NH2-and COOH-terminal deletion analysis revealed that both the PH and putative guanine nucleotide exchange factor domains are required, but the zinc butterfly is dispensable, for transformation.", "output": {"entities": {"gene": [{"text": "PH", "start": 63, "end": 65}, {"text": "guanine nucleotide exchange factor domains", "start": 79, "end": 121}]}}, "schema": []}
{"input": "The objective of our study was to evaluate the age, sex, clinical conditions, family history, site, catheter association, means of radiologic evaluation, development of pulmonary involvement, prevalence of antithrombin III, protein C and protein S deficiencies, and lupus anticoagulants in children who suffered a thrombotic event.", "output": {"entities": {"gene": [{"text": "antithrombin III", "start": 206, "end": 222}, {"text": "protein C", "start": 224, "end": 233}, {"text": "protein S", "start": 238, "end": 247}]}}, "schema": []}
{"input": "Harel, E. M.", "output": {"entities": {}}, "schema": []}
{"input": "Radiotherapy and early orchiectomy in stage D1 prostatic carcinoma", "output": {"entities": {}}, "schema": []}
{"input": "Structural organization and developmental expression pattern of the mouse WD-repeat gene DMR-N9 immediately upstream of the myotonic dystrophy locus.", "output": {"entities": {"gene": [{"text": "mouse WD-repeat gene DMR-N9", "start": 68, "end": 95}, {"text": "myotonic dystrophy locus", "start": 124, "end": 148}]}}, "schema": []}
{"input": "The ARX2 procedure models the recorded signal as the sum of three signals: (a) the background EEG activity, modelled as an autoregressive process driven by a white noise; (b) a filtered version of a reference signal carrying the average information contained in each sweep; (c) a signal due to the ocular artefact propagation.", "output": {"entities": {}}, "schema": []}
{"input": "The expression of the gene encoding the enzyme (CYP19) is regulated, in part, by tissue-specific promoters through the use of alternative-splicing mechanisms.", "output": {"entities": {"gene": [{"text": "CYP19", "start": 48, "end": 53}]}}, "schema": []}
{"input": "CIITA mRNA is normally inducible by IFN-gamma in class II non-inducible, RB-defective lines, and in one line, re-expression of RB has no effect on CIITA mRNA induction levels.", "output": {"entities": {"gene": [{"text": "CIITA mRNA", "start": 0, "end": 10}, {"text": "IFN-gamma", "start": 36, "end": 45}, {"text": "RB", "start": 73, "end": 75}, {"text": "CIITA mRNA", "start": 147, "end": 157}]}}, "schema": []}
{"input": "Consistent with the protein expression data, V beta 8. 3 gene transcripts were found only in the transgenic lines with the wild-type promoter.", "output": {"entities": {"gene": [{"text": "V beta 8. 3 gene transcripts", "start": 45, "end": 73}]}}, "schema": []}
{"input": "One month after the DTaP booster vaccination, both groups had 6-to 40-fold increases in serum antibody concentrations to all antigens tested; the concentrations against the three pertussis antigens were higher in the DTaP-primed children (p < 0. 05).", "output": {"entities": {"gene": [{"text": "pertussis antigens", "start": 179, "end": 197}]}}, "schema": []}
{"input": "Interestingly, this amino-terminal determinant appears not to reside in the HSV-alpha TIF, which displays no independent amino-terminal activity.", "output": {"entities": {"gene": [{"text": "alpha TIF", "start": 80, "end": 89}]}}, "schema": []}
{"input": "We also show that in fusions with the DNA binding domain of GAL4, full activity requires the entire BHV-alpha TIF, although both amino and carboxyl termini display some activity on their own.", "output": {"entities": {"gene": [{"text": "GAL4", "start": 60, "end": 64}, {"text": "BHV-alpha TIF", "start": 100, "end": 113}]}}, "schema": []}
{"input": "To investigate the potential role of SP1, we examined nuclear extracts from HCMV-infected cells.", "output": {"entities": {"gene": [{"text": "SP1", "start": 37, "end": 40}]}}, "schema": []}
{"input": "Here we show that messenger RNAs encoding trans-sialidases containing the repeats are not present in epimastigotes but are abundant in trypomastigotes.", "output": {"entities": {}}, "schema": []}
{"input": "From May 1985 to May 1989, 126 necropsies were performed at the Sao Paulo City Morgue on cadavers of individuals AIDS victims whose unnatural deaths had prompted police investigations.", "output": {"entities": {}}, "schema": []}
{"input": "A model with age and weight described the best fit for TBBMD, whereas age, weight, and height described the best fit for total body TBBMC.", "output": {"entities": {}}, "schema": []}
{"input": "As retinoic acid and thyroid hormone are frequently involved in developmental regulatory processes, it is possible that this element may be important in the process of islet cell differentiation.", "output": {"entities": {}}, "schema": []}
{"input": "The C-terminal peptide sequences of the human lymphocyte-specific high mobility group (HMG)-box transcription factor TCF-1 are determined by alternative splice mechanisms affecting the exons VIII to X.", "output": {"entities": {"gene": [{"text": "human lymphocyte-specific high mobility group (HMG)-box transcription factor TCF-1", "start": 40, "end": 122}]}}, "schema": []}
{"input": "Thromboxane B2 increased (97 +/-105 versus 40 +/-26 pg/ml) and was significantly higher during heparin free hemodialysis than during hemodialysis with heparin (p = 0. 01, Wilcoxon matched pairs signed rank test).", "output": {"entities": {}}, "schema": []}
{"input": "To explore the mechanism of RSK activation, a cloned human RSK cDNA (RSK3) was used to generate and characterize several site-directed RSK mutants; K91A (N-Lys, NH2-terminal ATP-binding mutant), K444A (C-Lys, COOH-terminal ATP-binding mutant), N/C-Lys (double ATP-binding mutant) T570A (C-Thr, mutant of the putative MAPK phosphorylation site in subdomain VIII of the C-domain), S218A (N-Ser, mutant of the corresponding NH2-terminal residue).", "output": {"entities": {"gene": [{"text": "RSK", "start": 28, "end": 31}, {"text": "RSK", "start": 59, "end": 62}, {"text": "RSK3", "start": 69, "end": 73}, {"text": "RSK mutants", "start": 135, "end": 146}, {"text": "MAPK", "start": 317, "end": 321}]}}, "schema": []}
{"input": "In contrast, both C-Lys and C-Thr retained high levels of kinase activity and were capable of responding to stimulation.", "output": {"entities": {}}, "schema": []}
{"input": "Conversely, treatment of human protein-tyrosine phosphatase alpha-overexpressing cells with phenylarsine oxide led to a loss of the constitutive NF-kappa B activity.", "output": {"entities": {"gene": [{"text": "human protein-tyrosine phosphatase alpha", "start": 25, "end": 65}, {"text": "NF-kappa B", "start": 145, "end": 155}]}}, "schema": []}
{"input": "A TATA-less promoter containing binding sites for ubiquitous transcription factors mediates cell type-specific regulation of the gene for transcription enhancer factor-1 (TEF-1).", "output": {"entities": {"gene": [{"text": "transcription enhancer factor-1", "start": 138, "end": 169}, {"text": "TEF-1", "start": 171, "end": 176}]}}, "schema": []}
{"input": "Since electrical stimulation of neurones may activate not only cell bodies but also neuronal fibres, this study aimed to test a selectively cholinergic neurochemical stimulation of the rat substantia innominata (SI) by the local microinjection of carbachol; the effects of this acetylcholine agonist were compared with glutamate.", "output": {"entities": {}}, "schema": []}
{"input": "We purified both proteins from human platelet membranes using DEAE-Sepharose chromatography followed by mAb F11 affinity chromatography.", "output": {"entities": {"gene": [{"text": "mAb F11", "start": 104, "end": 111}]}}, "schema": []}
{"input": "The homeobox gene ATK1 of Arabidopsis thaliana is expressed in the shoot apex of the seedling and in flowers and inflorescence stems of mature plants.", "output": {"entities": {"gene": [{"text": "homeobox gene ATK1", "start": 4, "end": 22}]}}, "schema": []}
{"input": "The most likely explanation for this is that gold principally accumulates in the Kupffer cells and renal cortex and these cells do not express Type I deiodinase.", "output": {"entities": {"gene": [{"text": "Type I deiodinase", "start": 143, "end": 160}]}}, "schema": []}
{"input": "These results suggest that different models of intestinal ischemia have different cytokine profiles and that the early TNF response associated with SMA occlusion model is primarily due to the laparotomy.", "output": {"entities": {"gene": [{"text": "TNF", "start": 119, "end": 122}]}}, "schema": []}
{"input": "Our evidence derives from three principal observations: 1) a transfection construct containing only 122 nucleotides (nt) of promoter 1 and 328 nt of the 5'-UTR retained full PGE2-stimulated reporter expression; 2) maximal PGE2-driven reporter expression required the presence of nt 196 to 328 of exon 1 when tested within the context of IGF-I promoter 1; 3) cotransfection of IGF-I promoter-luciferase-reporter constructs with a plasmid encoding the alpha-isoform of the catalytic subunit of murine cAMP-dependent protein kinase (PKA) produced results comparable to those seen with PGE2 treatment, whereas cotransfection with a plasmid encoding a mutant regulatory subunit of PKA that cannot bind cAMP blocked PGE2-induced reporter expression.", "output": {"entities": {"gene": [{"text": "IGF-I promoter 1", "start": 337, "end": 353}, {"text": "IGF-I promoter", "start": 376, "end": 390}, {"text": "luciferase", "start": 391, "end": 401}, {"text": "murine cAMP-dependent protein kinase", "start": 492, "end": 528}, {"text": "PKA", "start": 530, "end": 533}, {"text": "PKA", "start": 676, "end": 679}]}}, "schema": []}
{"input": "The changes after treatment were observed chiefly by electromyography while sensory and motor improvement were also recorded as auxiliary indicators.", "output": {"entities": {}}, "schema": []}
{"input": "Band-shift assays and DNase I footprinting experiments using purified 42 kDa repressor isoform confirmed that CIRs 5 and 6 were indeed the targets for binding of this protein.", "output": {"entities": {"gene": [{"text": "DNase I", "start": 22, "end": 29}, {"text": "CIRs 5 and 6", "start": 110, "end": 122}]}}, "schema": []}
{"input": "Retransformation of uvsH77 mutants with the rescued cosmids from the MMS-resistant transformants resulted in restoration of both UV and MMS resistance to wild-type levels.", "output": {"entities": {"gene": [{"text": "uvsH77 mutants", "start": 20, "end": 34}]}}, "schema": []}
{"input": "Furthermore, this element confers p53 induction to the otherwise nonresponsive adenovirus major late promoter.", "output": {"entities": {"gene": [{"text": "p53", "start": 34, "end": 37}]}}, "schema": []}
{"input": "In flies, the dShc protein physically associates with the activated Drosophila epidermal growth factor receptor homolog (DER) and is inducibly phosphorylated on tyrosine by DER.", "output": {"entities": {"gene": [{"text": "dShc protein", "start": 14, "end": 26}, {"text": "Drosophila epidermal growth factor receptor homolog", "start": 68, "end": 119}, {"text": "DER", "start": 121, "end": 124}, {"text": "DER", "start": 173, "end": 176}]}}, "schema": []}
{"input": "A potential binding site for the dShc PTB domain is located at Tyr-1228 of DER.", "output": {"entities": {"gene": [{"text": "dShc", "start": 33, "end": 37}, {"text": "DER", "start": 75, "end": 78}]}}, "schema": []}
{"input": "A Drosophila shc gene product is implicated in signaling by the DER receptor tyrosine kinase.", "output": {"entities": {"gene": [{"text": "Drosophila shc gene product", "start": 2, "end": 29}, {"text": "DER receptor tyrosine kinase", "start": 64, "end": 92}]}}, "schema": []}
{"input": "This inhibition can be overcome by mutating either the exon' s 5' or 3' splice site to make it correspond more closely to the relevant consensus sequence.", "output": {"entities": {}}, "schema": []}
{"input": "Biochemical analysis shows that Ssm1p is a structural protein that forms part of the largest 60S ribosomal subunit, which does not exist in a pool of free proteins.", "output": {"entities": {"gene": [{"text": "Ssm1p", "start": 32, "end": 37}, {"text": "60S ribosomal subunit", "start": 93, "end": 114}]}}, "schema": []}
{"input": "In wild-type cells, SSM1b transcripts accumulate to twice the level of SSM1a transcripts, suggesting that SSM1b is responsible for the majority of the Ssm1p pool.", "output": {"entities": {"gene": [{"text": "SSM1b transcripts", "start": 20, "end": 37}, {"text": "SSM1a transcripts", "start": 71, "end": 88}, {"text": "SSM1b", "start": 106, "end": 111}, {"text": "Ssm1p", "start": 151, "end": 156}]}}, "schema": []}
{"input": "Northern blot analysis revealed the expression of LIMK-1 mRNA predominantly in the brain and the expression of LIMK-2 mRNA in various tissues in the rat.", "output": {"entities": {"gene": [{"text": "LIMK-1 mRNA", "start": 50, "end": 61}, {"text": "LIMK-2 mRNA", "start": 111, "end": 122}]}}, "schema": []}
{"input": "On the basis of this anatomic concept, the brachioplasty procedure was modified to provide secure anchoring of the arm flap to the axillary fascia along with strong superficial fascial system repair of incisions, reducing the risk of widening or migration of scars and unnatural contours.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, microinjection of dominant negative forms of Rac and Cdc42 or of the Rho inhibitor C3 transferase blocked serum-induced DNA synthesis.", "output": {"entities": {"gene": [{"text": "Rac", "start": 58, "end": 61}, {"text": "Cdc42", "start": 66, "end": 71}, {"text": "Rho", "start": 82, "end": 85}, {"text": "C3 transferase", "start": 96, "end": 110}]}}, "schema": []}
{"input": "INF-alpha therapy has been a major development in the treatment of CML.", "output": {"entities": {"gene": [{"text": "INF-alpha", "start": 0, "end": 9}]}}, "schema": []}
{"input": "A series of amino terminal deletion mutants (d10, d20, d27, d31, d40, d44, and d73) were compared for processing, cell surface expression, and maintenance of their biological attributes by recombinant expression of mutant genes using a plasmid vector (pcDL-SR alpha-296) in CV-1 and HeLa cells.", "output": {"entities": {}}, "schema": []}
{"input": "Intrathecal acetyl cholinesterase inhibitors produce analgesia that is synergistic with morphine and clonidine in rats.", "output": {"entities": {"gene": [{"text": "acetyl cholinesterase", "start": 12, "end": 33}]}}, "schema": []}
{"input": "After determining isoflurane MAC in triplicate, birds were given a mu-opioid agonist (morphine, n = 9) or a kappa-opioid agonist (U50488H, n = 9).", "output": {"entities": {}}, "schema": []}
{"input": "Max was constantly transcribed at a relatively low level during cell cycle progression.", "output": {"entities": {"gene": [{"text": "Max", "start": 0, "end": 3}]}}, "schema": []}
{"input": "The yeast enzyme was 6-fold slower than the mammalian enzymes, which made it amenable to pre-steady-state stopped-flow spectroscopic kinetic analysis at 30 degrees C and pH 6. 0.", "output": {"entities": {}}, "schema": []}
{"input": "Key areas of the selection process including medical and surgical alternatives to transplantation, the composition of the transplant work-up, specific inclusion criteria as well as specific psychosocial factors and specific disease etiologies and co-morbidities that might represent contraindications were extensively reviewed.", "output": {"entities": {}}, "schema": []}
{"input": "In both shoots and roots, GT-2 protein is undetectable in meristematic tissue but becomes expressed at later stages of cellular development, consistent with a role in contributing to the pattern of phytochrome A gene expression.", "output": {"entities": {"gene": [{"text": "GT-2 protein", "start": 26, "end": 38}, {"text": "phytochrome A gene", "start": 198, "end": 216}]}}, "schema": []}
{"input": "Comparative DNA sequence analysis showed the Genethon microsatellite D19S596 lies 2. 2 kb downstream of the coding region of FUT1, indicating that the cluster comprising the closely linked FUT1 and FUT2 genes is located 4 cM distal to D19S412 (lod score 13. 7) and 9 cM proximal to D19S571 (lod score 11. 7).", "output": {"entities": {"gene": [{"text": "microsatellite D19S596", "start": 54, "end": 76}, {"text": "FUT1", "start": 125, "end": 129}, {"text": "FUT1", "start": 189, "end": 193}, {"text": "FUT2 genes", "start": 198, "end": 208}, {"text": "D19S412", "start": 235, "end": 242}, {"text": "D19S571", "start": 282, "end": 289}]}}, "schema": []}
{"input": "We conclude that transcription activation by LEF-1 in vitro is a chromatin-dependent process that requires a functional trans-activation domain in addition to the HMG domain.", "output": {"entities": {"gene": [{"text": "LEF-1", "start": 45, "end": 50}, {"text": "HMG domain", "start": 163, "end": 173}]}}, "schema": []}
{"input": "TH-SH3 binding in vitro is abolished by specific, single amino acid substitutions within the Btk TH domain or the Fyn SH3 domain.", "output": {"entities": {"gene": [{"text": "TH", "start": 0, "end": 2}, {"text": "SH3", "start": 3, "end": 6}, {"text": "Btk TH domain", "start": 93, "end": 106}, {"text": "Fyn SH3 domain", "start": 114, "end": 128}]}}, "schema": []}
{"input": "These results indicate that K-glypican is a novel GPI-anchored HSPG involved in embryonic development.", "output": {"entities": {"gene": [{"text": "K-glypican", "start": 28, "end": 38}, {"text": "GPI-anchored HSPG", "start": 50, "end": 67}]}}, "schema": []}
{"input": "Protein S levels were virtually undetectable at the time of admission and failed to respond to infusions of fresh frozen plasma, despite correction of other procoagulant and anticoagulant factors.", "output": {"entities": {"gene": [{"text": "Protein S", "start": 0, "end": 9}]}}, "schema": []}
{"input": "The test was not performed in 3923 patients because of contraindications.", "output": {"entities": {}}, "schema": []}
{"input": "The ubiquitous transcription factor Oct-1 forms complexes with an octamer motif present within FPIV by gel shift analysis with liver and kidney extracts, making Oct-1 an intriguing candidate for partnership in androgen regulation.", "output": {"entities": {"gene": [{"text": "Oct-1", "start": 36, "end": 41}, {"text": "Oct-1", "start": 161, "end": 166}]}}, "schema": []}
{"input": "We used deletion analysis and transfection assays with reporter gene constructs to examine the transcription control elements in the 5' flanking region of the human EpoR gene.", "output": {"entities": {"gene": [{"text": "human EpoR gene", "start": 159, "end": 174}]}}, "schema": []}
{"input": "Incubation of the purified fusion proteins with [gamma-32P] ATP in an in vitro assay showed that both proteins were capable of autophosphorylation.", "output": {"entities": {}}, "schema": []}
{"input": "The character of specific immune response in 101 immunized children and in 12 adults belonging to a high risk group with respect to VHB.", "output": {"entities": {}}, "schema": []}
{"input": "After nadolol, heart rate decreased (-22 +/-8%), and so did PBV and PBF (8. 8 +/-3. 4 vs.", "output": {"entities": {}}, "schema": []}
{"input": "Adrenergic system activation, indicated by metanephrine/epinephrine ratio, increased with time in losing males, except that after one month of cohabitation, turnover returned to levels that equaled those of control animals.", "output": {"entities": {}}, "schema": []}
{"input": "Transabdominal repair of type IV thoraco-abdominal aortic aneurysms.", "output": {"entities": {}}, "schema": []}
{"input": "A.", "output": {"entities": {}}, "schema": []}
{"input": "Primer extension and cDNA cloning were used to isolate the complete 5' end of the Nramp1 mRNA.", "output": {"entities": {"gene": [{"text": "Nramp1 mRNA", "start": 82, "end": 93}]}}, "schema": []}
{"input": "Primer extension and S1 nuclease mapping experiments were used to locate the transcription initiation site of Nramp1 and revealed the presence of one major and several minor initiation sites.", "output": {"entities": {"gene": [{"text": "S1 nuclease", "start": 21, "end": 32}, {"text": "Nramp1", "start": 110, "end": 116}]}}, "schema": []}
{"input": "Sequence analysis of the 5'-flanking region of the CD69 gene revealed the presence of a potential TATA element 30 base pairs upstream of the major transcription initiation site and several putative binding sequences for inducible transcription factors (NF-kappa B, Egr-1, AP-1), which might mediate the inducible expression of this gene.", "output": {"entities": {"gene": [{"text": "CD69 gene", "start": 51, "end": 60}, {"text": "NF-kappa B", "start": 253, "end": 263}, {"text": "Egr-1", "start": 265, "end": 270}, {"text": "AP-1", "start": 272, "end": 276}]}}, "schema": []}
{"input": "The plasmin-derived D (approximately 105-kDa) product, however, could be cross-linked into DD dimers.", "output": {"entities": {"gene": [{"text": "plasmin-derived D (approximately 105-kDa) product", "start": 4, "end": 53}]}}, "schema": []}
{"input": "All clinical isolates were concomitantly tested by disk diffusion and agar dilution procedures as outlined by the National Committee for Clinical Laboratory Standards.", "output": {"entities": {}}, "schema": []}
{"input": "IgE levels showed higher values compared to normal individuals and IgE levels were higher in children groups than in adults regardless of the intensity of infection.", "output": {"entities": {"gene": [{"text": "IgE", "start": 0, "end": 3}, {"text": "IgE", "start": 67, "end": 70}]}}, "schema": []}
{"input": "Tissue-specific expression of the tmy-1 gene was determined by microinjection of a promoter/lacZ fusion gene and with immunohistochemistry by using affinity-purified tissue-specific anti-tropomyosins.", "output": {"entities": {"gene": [{"text": "tmy-1 gene", "start": 34, "end": 44}, {"text": "promoter/lacZ fusion gene", "start": 83, "end": 108}, {"text": "tissue-specific anti-tropomyosins", "start": 166, "end": 199}]}}, "schema": []}
{"input": "The nucleotide sequence of the chloroplast (cp) DNA from maize (Zea mays) has been completed.", "output": {"entities": {}}, "schema": []}
{"input": "Investigation of the control of coronavirus subgenomic mRNA transcription by using T7-generated negative-sense RNA transcripts.", "output": {"entities": {}}, "schema": []}
{"input": "Initiation of translation of the human hepatitis C virus (HCV) RNA genome occurs by internal ribosome entry into the 5' noncoding region (5' NCR) in a cap-independent manner.", "output": {"entities": {}}, "schema": []}
{"input": "Mean longitudinal extension of the epidural lesion was 2. 6 vertebral segments.", "output": {"entities": {}}, "schema": []}
{"input": "The association of p255 with splicing complexes is suggested by the finding that mAb CC3 can inhibit in vitro splicing and immunoprecipitate pre-messenger RNA and splicing products.", "output": {"entities": {"gene": [{"text": "p255", "start": 19, "end": 23}, {"text": "mAb CC3", "start": 81, "end": 88}]}}, "schema": []}
{"input": "L-735, 524 free base or sulfate salt was administered orally as suspension, solution or in solid dosage forms to fasted or fed Beagle dogs.", "output": {"entities": {}}, "schema": []}
{"input": "Doppler ultrasound studies of long-term follow-up of children with hemolytic-uremic syndrome", "output": {"entities": {}}, "schema": []}
{"input": "Thus, endemic cumlations of hepatitis A diseases are possible.", "output": {"entities": {}}, "schema": []}
{"input": "(1991).", "output": {"entities": {}}, "schema": []}
{"input": "The properties of the phi 29 SSB-ssDNA complex are described.", "output": {"entities": {"gene": [{"text": "SSB-ssDNA", "start": 29, "end": 38}]}}, "schema": []}
{"input": "This shows that the characteristically diffuse banding pattern of plant nuclear proteins interacting with the G-box is also observed in a binding assay using only one recombinant GBF.", "output": {"entities": {"gene": [{"text": "recombinant GBF", "start": 167, "end": 182}]}}, "schema": []}
{"input": "We studied 120 male and 42 female patients with early CAD who were unrelated to each other but were from families in which at least one other sibling had early CAD.", "output": {"entities": {}}, "schema": []}
{"input": "The physical linkage of the FHR2 and the factor H genes provides additional evidence for a close relatedness of complement factor H and the factor H-related proteins.", "output": {"entities": {"gene": [{"text": "FHR2", "start": 28, "end": 32}, {"text": "factor H genes", "start": 41, "end": 55}, {"text": "complement factor H", "start": 112, "end": 131}, {"text": "factor H-related proteins", "start": 140, "end": 165}]}}, "schema": []}
{"input": "Genomic structure and chromosomal location of the mouse pre-T-cell receptor alpha gene.", "output": {"entities": {"gene": [{"text": "mouse pre-T-cell receptor alpha gene", "start": 50, "end": 86}]}}, "schema": []}
{"input": "The third domain had the motif of a cAMP response element (CRE).", "output": {"entities": {}}, "schema": []}
{"input": "The tyrosine-phosphorylated state of CAK beta was not reduced on trypsinization, nor enhanced in response to plating 3Y1 cells onto fibronectin.", "output": {"entities": {"gene": [{"text": "CAK beta", "start": 37, "end": 45}, {"text": "fibronectin", "start": 132, "end": 143}]}}, "schema": []}
{"input": "Our results suggest that while many muscle gene E-boxes are capable of binding the previously characterized spectrum of MDF/bH-L-H heterodimers in vitro, MCK-L type E-boxes probably bind qualitatively different factors in vivo.", "output": {"entities": {"gene": [{"text": "MDF/bH-L-H heterodimers", "start": 120, "end": 143}, {"text": "MCK-L", "start": 154, "end": 159}]}}, "schema": []}
{"input": "A single-case experimental ABAB multiple baseline design was employed to test for treatment effectiveness.", "output": {"entities": {}}, "schema": []}
{"input": "These clones were found to share a common domain encoded by p (CA) n repeats; a simple sequence length polymorphism (SSLP).", "output": {"entities": {}}, "schema": []}
{"input": "In one glioblastoma cell line, a Shc-associated p190 was identified as the activated PDGFR.", "output": {"entities": {"gene": [{"text": "Shc", "start": 33, "end": 36}, {"text": "p190", "start": 48, "end": 52}, {"text": "PDGFR", "start": 85, "end": 90}]}}, "schema": []}
{"input": "The serum concentration of iP before dialysis (HD) was on average 3. 06 (+/-0. 81) mmol/l and D was on average 55. 6 (+/-10. 0) mmol.", "output": {"entities": {}}, "schema": []}
{"input": "A significant correlation between a number of functional parameters of gastric secretion, incretion and histological changes of gastric mucosa was found in patients with chronic gastritis.", "output": {"entities": {}}, "schema": []}
{"input": "The TAF factor appears to be particularly significant in OCD.", "output": {"entities": {}}, "schema": []}
{"input": "RNase protection analyses indicate that either 61-kDa CaM PDE mRNA or structurally related transcripts encoding different CaM PDE isoforms are expressed in a tissue-specific manner.", "output": {"entities": {"gene": [{"text": "RNase", "start": 0, "end": 5}, {"text": "61-kDa CaM PDE mRNA", "start": 47, "end": 66}, {"text": "CaM PDE isoforms", "start": 122, "end": 138}]}}, "schema": []}
{"input": "Little or no protection was detected using adrenal cortex, adrenal medulla, liver, kidney cortex, spleen, or T-lymphocyte total RNA.", "output": {"entities": {}}, "schema": []}
{"input": "The PDGFR mutants that failed to associate with PLC gamma were not able to mediate the PDGF-dependent production of inositol phosphates.", "output": {"entities": {"gene": [{"text": "PDGFR mutants", "start": 4, "end": 17}, {"text": "PLC gamma", "start": 48, "end": 57}, {"text": "PDGF", "start": 87, "end": 91}]}}, "schema": []}
{"input": "We found a direct correlation between the levels of transcription of the acc genes and the rate of cellular growth.", "output": {"entities": {"gene": [{"text": "acc genes", "start": 73, "end": 82}]}}, "schema": []}
{"input": "The hybridizing clone of V. vulnificus chromosomal DNA complemented a V. cholerae fur mutant.", "output": {"entities": {"gene": [{"text": "V. cholerae fur mutant", "start": 70, "end": 92}]}}, "schema": []}
{"input": "We generated transformed B lymphoblast cell lines from controls, from four patients with p47-phox-deficient chronic granulomatous disease, and from three parents.", "output": {"entities": {"gene": [{"text": "p47", "start": 89, "end": 92}, {"text": "phox", "start": 93, "end": 97}]}}, "schema": []}
{"input": "RNase protection and primer extension assays confirmed that the 5' non-coding exon is included in the DDT1 aFGF mRNA and that a major transcription start site is approximately 136 bp upstream of the 5' non-coding splice junction of this exon.", "output": {"entities": {"gene": [{"text": "RNase", "start": 0, "end": 5}, {"text": "aFGF mRNA", "start": 107, "end": 116}]}}, "schema": []}
{"input": "These results suggest that FK 506 is a useful immunosuppressive agent in kidney transplantation.", "output": {"entities": {}}, "schema": []}
{"input": "The roles of phorbol esters and cyclic AMP in mediating the GnRH response were also investigated.", "output": {"entities": {"gene": [{"text": "GnRH", "start": 60, "end": 64}]}}, "schema": []}
{"input": "RT-PCR using 1. D-specific primers showed that kidney, brain and prostate do not express 1. D mRNA even though kidney and brain are the most abundant source for aFGF protein.", "output": {"entities": {"gene": [{"text": "aFGF protein", "start": 161, "end": 173}]}}, "schema": []}
{"input": "Molecular cloning and characterization of two genes encoding gp138, a cell surface glycoprotein involved in the sexual cell fusion of Dictyostelium discoideum.", "output": {"entities": {"gene": [{"text": "genes encoding gp138", "start": 46, "end": 66}]}}, "schema": []}
{"input": "Two-dimensional phosphotryptic analyses indicate that phosphorylation on Ser-12 and Ser-48 in unstimulated cells is associated with the ability of overexpressed pp60c-src to potentiate beta-adrenergic signalling.", "output": {"entities": {"gene": [{"text": "pp60c-src", "start": 161, "end": 170}]}}, "schema": []}
{"input": "Piroximone is a new phosphodiesterase III inhibitor that combines inotropic and vasodilator properties.", "output": {"entities": {"gene": [{"text": "phosphodiesterase III", "start": 20, "end": 41}]}}, "schema": []}
{"input": "Cytogenetic studies were performed in lymphocytes from hospital workers exposed to low doses of radiation (1. 6-42. 71 mSv).", "output": {"entities": {}}, "schema": []}
{"input": "To study the origin of different fMLF-R transcripts, the genetic linkage of chemotactic receptor genes, and the regulation of fMLF-R gene expression, we determined the copy number, chromosomal location, structural organization, and 5'-flanking sequence of the human fMLF-R gene.", "output": {"entities": {"gene": [{"text": "fMLF-R transcripts", "start": 33, "end": 51}, {"text": "fMLF-R gene", "start": 126, "end": 137}, {"text": "human fMLF-R gene", "start": 260, "end": 277}]}}, "schema": []}
{"input": "The first exon encodes 66 bp of the 5'-untranslated sequence, while exon 2 encodes the coding and 3'-untranslated sequences.", "output": {"entities": {}}, "schema": []}
{"input": "The genomic structure of four members of the SRC-family revealed nearly identical exon/intron boundaries within the catalytic domain of this family.", "output": {"entities": {"gene": [{"text": "SRC-family", "start": 45, "end": 55}]}}, "schema": []}
{"input": "Since we have observed effects of growth factors and cAMP as well as estradiol (E2) on regulation of expression of some genes stimulated by the estrogen receptor (ER), we have undertaken studies to examine directly whether activators of protein kinases can modulate transcriptional activity of the ER.", "output": {"entities": {"gene": [{"text": "estrogen receptor", "start": 144, "end": 161}, {"text": "ER", "start": 163, "end": 165}, {"text": "ER", "start": 298, "end": 300}]}}, "schema": []}
{"input": "Using the polymerase chain reaction, Whipple-specific DNA fragments of 284 base pairs from the genome of the Whipple bacterium (Tropheryma whippelii) were demonstrated.", "output": {"entities": {}}, "schema": []}
{"input": "RNA polymerase bound to the + 10A promoter partially protects a 20 base-pair sequence from DNase I digestion upstream of the start site.", "output": {"entities": {"gene": [{"text": "RNA polymerase", "start": 0, "end": 14}, {"text": "DNase I", "start": 91, "end": 98}]}}, "schema": []}
{"input": "Salivary sodium, calcium, and magnesium concentrations were significantly higher in the SLE patients with systemic lupus erythematosus, whereas potassium and total protein concentrations and amylase activity did not differ significantly from the controls.", "output": {"entities": {"gene": [{"text": "amylase", "start": 191, "end": 198}]}}, "schema": []}
{"input": "Chem.", "output": {"entities": {}}, "schema": []}
{"input": "Recombinant plasmid pFV100 was subsequently isolated by its ability to complement B-band expression in ge6.", "output": {"entities": {"gene": [{"text": "ge6", "start": 103, "end": 106}]}}, "schema": []}
{"input": "The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae.", "output": {"entities": {}}, "schema": []}
{"input": "Protein phosphorylation appears to play a critical role in uPA gene expression in these cells; protein kinase C-activating phorbol esters cooperate with pp60v-src to synergistically increase uPA mRNA, whereas cyclic AMP (cAMP)-dependent protein kinase-activating agents (e. g., 8-bromo cAMP) repress uPA mRNA levels.", "output": {"entities": {"gene": [{"text": "uPA gene", "start": 59, "end": 67}, {"text": "protein kinase C", "start": 95, "end": 111}, {"text": "pp60v-src", "start": 153, "end": 162}, {"text": "uPA mRNA", "start": 191, "end": 199}, {"text": "cyclic AMP (cAMP)-dependent protein kinase", "start": 209, "end": 251}, {"text": "uPA mRNA", "start": 300, "end": 308}]}}, "schema": []}
{"input": "This 300 bp 5'-upstream sequence of K3 keratin gene, which can function in vitro as a keratinocyte-specific promoter, contains two clusters of partially overlapping motifs, one with an NFkB consensus sequence and another with a GC box.", "output": {"entities": {"gene": [{"text": "K3 keratin gene", "start": 36, "end": 51}, {"text": "NFkB", "start": 185, "end": 189}]}}, "schema": []}
{"input": "BACKGROUND: Delineation of the morphologic aspects of age-related macular degeneration (ARMD) is helpful in correlation with the clinical features and may contribute to understanding the pathogenesis.", "output": {"entities": {}}, "schema": []}
{"input": "An abundant 1. 1-kb virion-sense polyadenylated RNA and four complementary-sense polyadenylated RNAs of 1. 7, 1. 5, 1. 3, and 0. 7 kb have been identified by northern blot hybridization, confirming the bidirectional transcription strategy implied by the arrangement of ORFs.", "output": {"entities": {}}, "schema": []}
{"input": "Risk factors associated with a high seroprevalence of hepatitis C virus infection in Egyptian blood donors.", "output": {"entities": {}}, "schema": []}
{"input": "Here the cloning and molecular analysis of the Zm-ERabp1, Zm-ERabp4, and Zm-ERabp5 genes is presented.", "output": {"entities": {"gene": [{"text": "Zm-ERabp1", "start": 47, "end": 56}, {"text": "Zm-ERabp4", "start": 58, "end": 67}, {"text": "Zm-ERabp5 genes", "start": 73, "end": 88}]}}, "schema": []}
{"input": "This agent, isolated from the fungus Streptomyces tsukubaensis, has a mechanism of action similar to that of cyclosporine.", "output": {"entities": {}}, "schema": []}
{"input": "DNase I footprinting of the proximal promoter revealed four regions of protection.", "output": {"entities": {"gene": [{"text": "DNase I", "start": 0, "end": 7}]}}, "schema": []}
{"input": "Finally, the stability of the nucleotide binding function of the two proteins is similar as assessed by sensitivity to urea.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, an mck1 mds1 mrk1 triple disruptant was viable.", "output": {"entities": {"gene": [{"text": "mck1 mds1 mrk1", "start": 16, "end": 30}]}}, "schema": []}
{"input": "However, there were some properties of Rak that are distinct from Src-like kinases: (a) expression of Rak was predominantly in epithelial-derived cell lines and tissues, especially normal liver and kidney, and cell lines of breast and colon origin; (b) Rak does not harbor the NH2-terminal glycine essential for myristylation and membrane localization; and (c) Rak possesses a putative bipartite nuclear localization signal in the SH2 domain, and subcellular fractionation studies revealed that p54rak resides predominantly in the nucleus.", "output": {"entities": {"gene": [{"text": "Rak", "start": 39, "end": 42}, {"text": "Src-like kinases", "start": 66, "end": 82}, {"text": "Rak", "start": 102, "end": 105}, {"text": "Rak", "start": 253, "end": 256}, {"text": "Rak", "start": 361, "end": 364}, {"text": "SH2 domain", "start": 431, "end": 441}, {"text": "p54rak", "start": 495, "end": 501}]}}, "schema": []}
{"input": "A small amount of HSP81-1 mRNA was detected only in roots.", "output": {"entities": {"gene": [{"text": "HSP81-1 mRNA", "start": 18, "end": 30}]}}, "schema": []}
{"input": "Cell adhesion and migration assays demonstrate that alpha 6 beta 1 is the major laminin receptor in undifferentiated F9 cells as well as F9-derived PE cells.", "output": {"entities": {"gene": [{"text": "alpha 6 beta 1", "start": 52, "end": 66}, {"text": "laminin receptor", "start": 80, "end": 96}]}}, "schema": []}
{"input": "No local destruction by tumor or infection could be demonstrated apart from HIV infection.", "output": {"entities": {}}, "schema": []}
{"input": "Among the mixed race persons one Chukcha-Eskimo had AS, one Eskimo-Russian had psoriatic arthritis (PsA).", "output": {"entities": {}}, "schema": []}
{"input": "Our data complement other studies of circumpolar populations and reinforce the reported high prevalences of SPA and HLA-B27 among those populations.", "output": {"entities": {"gene": [{"text": "HLA-B27", "start": 116, "end": 123}]}}, "schema": []}
{"input": "Clinical studies SY5555 was administered to 45 patients with various infectious diseases (2 with acute pharyngitis, 8 with acute tonsillitis, 4 with lacunar tonsillitis, 3 each with acute bronchitis, pneumonia and pertussis, 7 with scarlet fever, 3 with impetigo contagiosa, 6 with acute urinary tract infections, 2 with balanoposthitis and 1 each with cervical lymphadenitis, S. S. S. S., vulvitis and acute colitis) at daily doses between 3. 4-10 mg/kg, t. i. d., for 3-14 days.", "output": {"entities": {}}, "schema": []}
{"input": "Although most SH2-pTyr interactions occur between two different types of molecules, some appear to involve only a single molecular type.", "output": {"entities": {"gene": [{"text": "SH2", "start": 14, "end": 17}, {"text": "pTyr", "start": 18, "end": 22}]}}, "schema": []}
{"input": "RESULTS: Closure time of fistulas in patients receiving TPN + somatostatin was significantly shorter (13. 86 +/-1. 84 versus 20. 4 +/-2. 89 days) than in those receiving TPN alone.", "output": {"entities": {"gene": [{"text": "somatostatin", "start": 62, "end": 74}]}}, "schema": []}
{"input": "Scratching during sleep in children with atopic dermatitis is associated with increased VO2.", "output": {"entities": {}}, "schema": []}
{"input": "Within-subject BP differences between fish oil and corn oil treatment were similar for Dinamap (3. 2 +/-1. 8/2. 5 +/-1. 0 mm Hg) and for 24-h ABP (2. 5 +/-1. 0/2. 3 +/-0. 8 mm Hg), but were more significant with the latter.", "output": {"entities": {}}, "schema": []}
{"input": "Escherichia coli JRG582 is an ampD ampE deletion derivative of strain HfrH and accordingly it is derepressed for expression of the cloned inducible beta-lactamase gene of Citrobacter freundii, carried on plasmid pNU305.", "output": {"entities": {"gene": [{"text": "ampD ampE", "start": 30, "end": 39}, {"text": "beta-lactamase gene", "start": 148, "end": 167}]}}, "schema": []}
{"input": "Such a mechanism may allow acceleration of degenerative joint conditions, and may account for the increased prevalence of such conditions seen with HMS subjects.", "output": {"entities": {}}, "schema": []}
{"input": "Solitary thyroid nodule.", "output": {"entities": {}}, "schema": []}
{"input": "Male contraception: ideas for the future.", "output": {"entities": {}}, "schema": []}
{"input": "While daily food intake was almost constant regardless of the dietary protein level, water intake and urine volume increased with increasing the dietary protein.", "output": {"entities": {}}, "schema": []}
{"input": "We propose that Mad and Medea encode rate-limiting components integral to dpp pathways throughout development.", "output": {"entities": {"gene": [{"text": "Mad", "start": 16, "end": 19}, {"text": "Medea", "start": 24, "end": 29}, {"text": "dpp", "start": 74, "end": 77}]}}, "schema": []}
{"input": "Transcriptional regulation of the vacuolar H (+)-ATPase B2 subunit gene in differentiating THP-1 cells.", "output": {"entities": {"gene": [{"text": "vacuolar H (+)-ATPase B2 subunit gene", "start": 34, "end": 71}]}}, "schema": []}
{"input": "However, the inability to export RNA from the nucleus to the cytoplasm was not limited to a particular phase of the cell division cycle.", "output": {"entities": {}}, "schema": []}
{"input": "An E box element is required for the expression of the ad4bp gene, a mammalian homologue of ftz-f1 gene, which is essential for adrenal and gonadal development.", "output": {"entities": {"gene": [{"text": "ad4bp gene", "start": 55, "end": 65}, {"text": "mammalian homologue of ftz-f1 gene", "start": 69, "end": 103}]}}, "schema": []}
{"input": "Inhibition assays performed with over 30 different natural and synthetic sialylated and/or sulfated compounds are utilized to define in greater detail specific structural features involved in oligosaccharide-protein binding.", "output": {"entities": {}}, "schema": []}
{"input": "The amino acid sequence of the protein in the region of the specificity pocket is similar to that of S. griseus proteases A, B, and C.", "output": {"entities": {"gene": [{"text": "S. griseus proteases A, B, and C", "start": 101, "end": 133}]}}, "schema": []}
{"input": "This experimental design was used to determine the effect of displacement of the alpha 4-2 binding site on the repression of alpha 4 gene transcription by ICP4.", "output": {"entities": {"gene": [{"text": "alpha 4-2 binding site", "start": 81, "end": 103}, {"text": "alpha 4 gene", "start": 125, "end": 137}, {"text": "ICP4", "start": 155, "end": 159}]}}, "schema": []}
{"input": "Immediate-early transcription from the channel catfish virus genome: characterization of two immediate-early transcripts.", "output": {"entities": {"gene": [{"text": "immediate-early transcripts", "start": 93, "end": 120}]}}, "schema": []}
{"input": "The GRE at nucleotide 7640 is a composite GRE (cGRE) containing an overlapping activator protein-1 (AP-1) motif for the c-jun homodimer and c-jun/c-fos heterodimer.", "output": {"entities": {"gene": [{"text": "activator protein-1", "start": 79, "end": 98}, {"text": "AP-1", "start": 100, "end": 104}, {"text": "c-jun homodimer", "start": 120, "end": 135}, {"text": "c-jun", "start": 140, "end": 145}, {"text": "c-fos", "start": 146, "end": 151}]}}, "schema": []}
{"input": "In contrast to some results previously published for a very close sequence variant (see ref.", "output": {"entities": {}}, "schema": []}
{"input": "Transcriptional activation by thyroid hormone (T3) requires interactions between the T3 receptor (TR) and T3 response elements (TREs) composed of two copies of sequences related to AGGTCA.", "output": {"entities": {"gene": [{"text": "T3 receptor", "start": 85, "end": 96}, {"text": "TR", "start": 98, "end": 100}]}}, "schema": []}
{"input": "A multivariate analysis of risk factors for relapse examined age, WBC at diagnosis, blast count at diagnosis, percentage of marrow blasts, FAB subtype, the number of remission induction courses to achieve a remission, maintenance therapy, consolidation therapy, marrow cell dose, donor-recipient sex, GVHD prophylaxis regimen and isolation and decontamination in laminar airflow rooms.", "output": {"entities": {"gene": [{"text": "FAB", "start": 139, "end": 142}]}}, "schema": []}
{"input": "Carnitine palmitoyltransferase (CPT) II deficiency is the most common inherited disorder of lipid metabolism affecting skeletal muscle.", "output": {"entities": {"gene": [{"text": "Carnitine palmitoyltransferase (CPT) II", "start": 0, "end": 39}]}}, "schema": []}
{"input": "We show that these three gain-of-function mutants differ considerably in their ability to bypass the sex determination signal, with SxlM4 being the strongest and SxlM1 the weakest.", "output": {"entities": {"gene": [{"text": "SxlM4", "start": 132, "end": 137}, {"text": "SxlM1", "start": 162, "end": 167}]}}, "schema": []}
{"input": "We show that these three gain-of-function mutants differ considerably in their ability to bypass the sex determination signal, with SxlM4 being the strongest and SxlM1 the weakest.", "output": {"entities": {"gene": [{"text": "SxlM4", "start": 132, "end": 137}, {"text": "SxlM1", "start": 162, "end": 167}]}}, "schema": []}
{"input": "Blood pressure also was increased by lidocaine (6 mg kg-1).", "output": {"entities": {}}, "schema": []}
{"input": "Anesthesiologists often use more than one drug in a patient to achieve a target response, such as a desired blood pressure.", "output": {"entities": {}}, "schema": []}
{"input": "We suggest that this gene cluster codes for (parts of) a multisubunit cytochrome c haem lyase.", "output": {"entities": {"gene": [{"text": "multisubunit cytochrome c haem lyase", "start": 57, "end": 93}]}}, "schema": []}
{"input": "In this paper, a comparison between the number and shape of corneal endothelial cells has been performed in 25 patients before and 6 months after PRK.", "output": {"entities": {}}, "schema": []}
{"input": "Standard reference sources indicate that an able-bodied 11-year-old child of comparable height requires 1, 493 kcal/d for support of basal metabolic functions.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast to the myoD promoter, the myoD enhancer shows striking conservation between humans and mice both in its sequence and its distal position.", "output": {"entities": {"gene": [{"text": "myoD promoter", "start": 19, "end": 32}, {"text": "myoD enhancer", "start": 38, "end": 51}]}}, "schema": []}
{"input": "However, a clear difference exists between myoblasts and 10T1/2 cells (and other non-muscle cell types) in the chromatin structure of the chromosomal myoD core enhancer, suggesting that the myoD enhancer is repressed by epigenetic mechanisms in 10T1/2 cells.", "output": {"entities": {"gene": [{"text": "myoD core enhancer", "start": 150, "end": 168}, {"text": "myoD enhancer", "start": 190, "end": 203}]}}, "schema": []}
{"input": "Using Ki-ras-transformed 3T3 cells as a model system, we show that both RA and the' dissociating' retinoids inhibit anchorage-independent cell proliferation, suggesting that retinoid-induced growth inhibition may be related to AP1 transrepression.", "output": {"entities": {"gene": [{"text": "Ki-ras", "start": 6, "end": 12}, {"text": "AP1", "start": 227, "end": 230}]}}, "schema": []}
{"input": "The Oct and HMG2 proteins also interact in vivo.", "output": {"entities": {"gene": [{"text": "Oct", "start": 4, "end": 7}, {"text": "HMG2 proteins", "start": 12, "end": 25}]}}, "schema": []}
{"input": "Atopic dermatitis is an \" itch which rashes and not a rash which itches \" and therefore, any patient treatment program should address the multiplicity of potential trigger factors that provoke this itching.", "output": {"entities": {}}, "schema": []}
{"input": "Primer extension experiments showed that there are two transcription initiation sites 16 bp apart in the mouse type 2 receptor gene.", "output": {"entities": {"gene": [{"text": "mouse type 2 receptor gene", "start": 105, "end": 131}]}}, "schema": []}
{"input": "The beta subunit of the Fc epsilon R1 is a 33-kDa tyrosine phosphoprotein, but the p33 Grb2-binding protein described in the present report is not the Fc epsilon R1 beta chain and its identity is unknown.", "output": {"entities": {"gene": [{"text": "Fc epsilon R1", "start": 24, "end": 37}, {"text": "p33 Grb2-binding protein", "start": 83, "end": 107}, {"text": "Fc epsilon R1 beta chain", "start": 151, "end": 175}]}}, "schema": []}
{"input": "To study the mechanisms as well as magnitude of the transmembrane transfer of bacterial products from the dialysate, we developed a computerized in vitro dialysis model which provides continuous pressure recording from the arterial, venous, dialysate inflow and outflow ports.", "output": {"entities": {}}, "schema": []}
{"input": "After 24 hour incubation, total cell-associated IL-1Ra and IL-1 beta were measured by specific radioimmunoassay.", "output": {"entities": {"gene": [{"text": "IL-1Ra", "start": 48, "end": 54}, {"text": "IL-1 beta", "start": 59, "end": 68}]}}, "schema": []}
{"input": "1972.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast, recent evidence suggests that children with sickle-hemoglobin C disease do not develop functional asplenia before 3 to 4 years of age and thus may not benefit from penicillin prophylaxis.", "output": {"entities": {"gene": [{"text": "sickle-hemoglobin C", "start": 57, "end": 76}]}}, "schema": []}
{"input": "Deletion analysis indicates that TBP and hTAFII18 bind to distinct domains of hTAFII28. hTAFII18 also interacts with TBP, but it interacts more strongly with hTAFII28 and hTAFII30.", "output": {"entities": {"gene": [{"text": "TBP", "start": 33, "end": 36}, {"text": "hTAFII18", "start": 41, "end": 49}, {"text": "hTAFII28", "start": 78, "end": 86}, {"text": "hTAFII18", "start": 88, "end": 96}, {"text": "TBP", "start": 117, "end": 120}, {"text": "hTAFII28", "start": 158, "end": 166}, {"text": "hTAFII30", "start": 171, "end": 179}]}}, "schema": []}
{"input": "Vascular endothelial cells undergo profound changes upon cellular activation including expression of a spectrum of cell activation-associated genes.", "output": {"entities": {}}, "schema": []}
{"input": "Because ATF-1 and CREM are known to bind to cAMP response elements (CRE), this functional sequence was named the kappa E3'-CRE.", "output": {"entities": {"gene": [{"text": "ATF-1", "start": 8, "end": 13}, {"text": "CREM", "start": 18, "end": 22}, {"text": "kappa E3'", "start": 113, "end": 122}]}}, "schema": []}
{"input": "The amino acid sequences of the known largest subunits of DdRPs from different species contain highly conserved regions.", "output": {"entities": {"gene": [{"text": "DdRPs", "start": 58, "end": 63}]}}, "schema": []}
{"input": "The TTG-2 gene has been identified at the site of chromosomal translocations in acute T-cell leukemia' s (T-ALL).", "output": {"entities": {"gene": [{"text": "TTG-2 gene", "start": 4, "end": 14}]}}, "schema": []}
{"input": "In vitro studies with blood cells incubated with acetate or bicarbonate ions in concentrations, which are observed in vivo during hemodialysis, suggest that probably these ions do not directly affect superoxide anions generation, erythrocyte SOD-1 and catalase activities and erythrocyte membrane lipid peroxidation.", "output": {"entities": {"gene": [{"text": "SOD-1", "start": 242, "end": 247}, {"text": "catalase", "start": 252, "end": 260}]}}, "schema": []}
{"input": "Short therapy with omeprazole 20 mg/b. i. d., clarithromycin 500 mg/b. i. d., and CBS 120 mg/q. i. d. is a safe, well tolerated combination that achieves a 80. 6% eradication rate of H. pylori and duodenal ulcer healing rates as good as those achieved by omeprazole 20 mg/d when given for 4 wk.", "output": {"entities": {}}, "schema": []}
{"input": "The concentration of mite allergen was very low (mean 0. 18 micrograms Der p milligrams sieved house dust), whereas that of cat allergen was high in homes with a cat (80. 8 micrograms Fel d milligrams) but also in homes with no cat (3. 2 micrograms Fel d milligrams).", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS: A comparison of the LysU crystal structure with the structures of seryl-and aspartyl-tRNA synthetases enables a conserved core to be identified.", "output": {"entities": {"gene": [{"text": "LysU", "start": 33, "end": 37}, {"text": "seryl-and aspartyl-tRNA synthetases", "start": 79, "end": 114}]}}, "schema": []}
{"input": "Whole bowel irrigation is a recently described technique to enhance the passage of drugs already beyond the pylorus.", "output": {"entities": {}}, "schema": []}
{"input": "The MPS1 open reading frame has been fused to those that encode the LexA protein or the GST protein and both of these constructs function in yeast.", "output": {"entities": {"gene": [{"text": "MPS1 open reading frame", "start": 4, "end": 27}, {"text": "LexA protein", "start": 68, "end": 80}, {"text": "GST protein", "start": 88, "end": 99}]}}, "schema": []}
{"input": "Hematopoietic growth factors have already had an enormous impact on transfusion practice by eliminating or reducing the need for red blood cell transfusions in a variety of anemic states characterized by an absolute or relative decrease in erythropoietin.", "output": {"entities": {"gene": [{"text": "Hematopoietic growth factors", "start": 0, "end": 28}, {"text": "erythropoietin", "start": 240, "end": 254}]}}, "schema": []}
{"input": "However, the mouse has previously been shown to possess only three forms of ADH.", "output": {"entities": {"gene": [{"text": "ADH", "start": 76, "end": 79}]}}, "schema": []}
{"input": "During IC breaths and following EC and VC breaths at rest, end-tidal CO2 pressure (PET, CO2) fell by 7. 5, 8. 5 and 9. 5 mmHg, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Phylogenetic analyses of 19 amino acid sequences of 6 related protein types indicate that actin-associated proteins related to gelsolin are monophyletic to a common ancestor and include flightless proteins.", "output": {"entities": {"gene": [{"text": "actin", "start": 90, "end": 95}, {"text": "gelsolin", "start": 127, "end": 135}, {"text": "flightless proteins", "start": 186, "end": 205}]}}, "schema": []}
{"input": "No homologs of other members of the Surfeit gene cluster were detected in close proximity to the D. melanogaster Surf-3/rpL7a gene.", "output": {"entities": {"gene": [{"text": "Surfeit gene cluster", "start": 36, "end": 56}, {"text": "Surf-3", "start": 113, "end": 119}, {"text": "rpL7a", "start": 120, "end": 125}]}}, "schema": []}
{"input": "Moreover, we found that cyclin E, in contrast to cyclin D1, was required for the G1/S transition even in cells lacking retinoblastoma protein function.", "output": {"entities": {"gene": [{"text": "cyclin E", "start": 24, "end": 32}, {"text": "cyclin D1", "start": 49, "end": 58}, {"text": "retinoblastoma protein", "start": 119, "end": 141}]}}, "schema": []}
{"input": "The predicted amino acid sequence of the SGC1 gene product includes a region with substantial similarity to the basic-helix-loop-helix domain of the Myc family of DNA-binding proteins.", "output": {"entities": {"gene": [{"text": "SGC1 gene product", "start": 41, "end": 58}, {"text": "Myc family", "start": 149, "end": 159}]}}, "schema": []}
{"input": "By creating Pax-6-BSAP fusion proteins, we were able to identify a short amino acid stretch in the N-terminal part of the paired domain which is responsible for these differences in DNA-binding specificity.", "output": {"entities": {"gene": [{"text": "Pax-6", "start": 12, "end": 17}, {"text": "BSAP", "start": 18, "end": 22}, {"text": "paired", "start": 122, "end": 128}]}}, "schema": []}
{"input": "To establish a possible association between familial dysfibrinogenemia and thrombophilia, data on cases with both affections were collected in a study within the framework of the SSC Subcommittee on Fibrinogen of the International Society on Thrombosis and Haemostasis.", "output": {"entities": {"gene": [{"text": "Fibrinogen", "start": 199, "end": 209}]}}, "schema": []}
{"input": "Conjugated estrogens shorten bleeding time in uraemia: a possible role of serotonin?", "output": {"entities": {}}, "schema": []}
{"input": "These six districts have an area of 34, 000 km2 and hold a population of 30 million.", "output": {"entities": {}}, "schema": []}
{"input": "According to symptoms, signs, imaging features, operation findings, the original places and the expansive directions of the tumor, they were divided into four clinical types: sellar, clival, occipito-temporal and extent.", "output": {"entities": {}}, "schema": []}
{"input": "The cases included 35 de novo diffuse aggressive lymphomas (DAL; 19 large-cell, 4 mixed-cell, and 12 large-cell immunoblastic), 52 transformed aggressive lymphomas derived from follicular lymphomas (TFL), 42 indolent follicular lymphomas (FL), 14 mantle cell lymphomas (MCL), and 27 small noncleaved cell lymphomas (SNCL).", "output": {"entities": {}}, "schema": []}
{"input": "Icterus and beta-thalassemia in Congolese children in Brazzaville", "output": {"entities": {}}, "schema": []}
{"input": "Female patients with breast cancer diagnosed between 1982 and 1991 at Roswell Park Cancer Institute (RPCI) in Buffalo, New York, who provided information on their cigarette smoking history at the time of their diagnosis were included.", "output": {"entities": {}}, "schema": []}
{"input": "Upon analysis of the tissue distribution of AAMP, it was found to be expressed strongly in endothelial cells, cytotrophoblasts, and poorly differentiated colon adenocarcinoma cells found in lymphatics.", "output": {"entities": {"gene": [{"text": "AAMP", "start": 44, "end": 48}]}}, "schema": []}
{"input": "Data from the V-HeFT II show that at 2-year follow-up, a progressive rise of plasma norepinephrine was observed in both treatment arms, suggesting that disease progresses despite treatment with either an angiotensin-converting enzyme inhibitor, enalapril, or vasodilator therapy with hydralazine/isosorbide dinitrate.", "output": {"entities": {"gene": [{"text": "angiotensin-converting enzyme", "start": 204, "end": 233}]}}, "schema": []}
{"input": "Analysis of Bcl-2/Bcl-2 homodimerization using both in vitro binding assays as well as a yeast two-hybrid method provided evidence in support of a head-to-tail model for Bcl-2/Bcl-2 homodimerization and revealed that sequences within the NH2-terminal A domain interact with a structure that requires the presence of both the carboxyl B and C domains in combination.", "output": {"entities": {"gene": [{"text": "Bcl-2", "start": 12, "end": 17}, {"text": "Bcl-2", "start": 18, "end": 23}, {"text": "Bcl-2", "start": 170, "end": 175}, {"text": "Bcl-2", "start": 176, "end": 181}]}}, "schema": []}
{"input": "The protein is composed of a central alpha-helical portion with globular domains at both NH2 and COOH termini, and the epitope to the monoclonal antibody resides in the central alpha-helical stalk.", "output": {"entities": {}}, "schema": []}
{"input": "Radioligand binding was indistinguishable for both transiently expressed constructs.", "output": {"entities": {}}, "schema": []}
{"input": "Diagnosis of FHCS has been weighed upon laparoscopic findings.", "output": {"entities": {}}, "schema": []}
{"input": "Human papillomavirus type 31b late gene expression is regulated through protein kinase C-mediated changes in RNA processing.", "output": {"entities": {"gene": [{"text": "Human papillomavirus type 31b late gene", "start": 0, "end": 39}, {"text": "protein kinase C", "start": 72, "end": 88}]}}, "schema": []}
{"input": "Interestingly, virions also contained smaller proteins that reacted with antibodies specific for the accessory proteins as well as SN and CAT fusion partners.", "output": {"entities": {"gene": [{"text": "SN", "start": 131, "end": 133}, {"text": "CAT fusion", "start": 138, "end": 148}]}}, "schema": []}
{"input": "Studies using an inhibitor or a mutant Lb proteinase indicated that stimulation of IRES-driven translation is mediated via proteolysis of some cellular component (s).", "output": {"entities": {"gene": [{"text": "mutant Lb proteinase", "start": 32, "end": 52}]}}, "schema": []}
{"input": "Restriction mapping analysis localized this cDNA to the HHV-6A (U1102) genomic BamHI G fragment, at the right end of the unique long segment of the genome and to the SalI L and SalI O fragments within the left and right terminal direct repeat regions, respectively.", "output": {"entities": {"gene": [{"text": "HHV-6A (U1102) genomic BamHI G fragment", "start": 56, "end": 95}, {"text": "SalI L", "start": 166, "end": 172}, {"text": "SalI O fragments", "start": 177, "end": 193}]}}, "schema": []}
{"input": "For replication reporter constructs where E1 and E2 are supplied in trans by the respective expression vectors, distance between the half sites seems to play a major role, yet the phasing relationships are measurable.", "output": {"entities": {"gene": [{"text": "E1", "start": 42, "end": 44}, {"text": "E2", "start": 49, "end": 51}]}}, "schema": []}
{"input": "As it had been previously reported that the 18-bp palindrome contains sufficient nucleotide sequence information for E1 binding, we speculate that a minimal E1 recognition motif is presented in each half site.", "output": {"entities": {"gene": [{"text": "E1", "start": 117, "end": 119}, {"text": "E1", "start": 157, "end": 159}]}}, "schema": []}
{"input": "METHODS: Out of 171 patients receiving anticoagulation between July 1992 and December 1993, 83 patients with hemispheric embolisms received heparin within 72 hours from onset (activated partial thromboplastin time [aPTT] 1. 5 times control value).", "output": {"entities": {"gene": [{"text": "thromboplastin", "start": 194, "end": 208}]}}, "schema": []}
{"input": "In the commercially available intravenous formulation of Cyclosporin A (Sandimmun), polyoxyethylated castor oil (Cremophor EL) is used as a solubilizing agent.", "output": {"entities": {}}, "schema": []}
{"input": "Sequence comparisons of prokaryotic RCR initiators has revealed a set of three common motifs, two of which, a putative metal coordination site and a downstream active-site tyrosine motif, could be tentatively identified in parvoviral replicator proteins.", "output": {"entities": {"gene": [{"text": "prokaryotic RCR initiators", "start": 24, "end": 50}, {"text": "parvoviral replicator proteins", "start": 223, "end": 253}]}}, "schema": []}
{"input": "The mean marginal discrepancy of provisional restorations was compared for restorations fabricated from stone, low-viscosity poly (vinyl siloxane), and medium-viscosity poly (vinyl siloxane).", "output": {"entities": {}}, "schema": []}
{"input": "The characterized Aplysia Afurin2 is a candidate PC that may play an important role in the processing of egg-laying hormone (ELH)-related precursors in the secretory cells of the atrial gland.", "output": {"entities": {"gene": [{"text": "Aplysia Afurin2", "start": 18, "end": 33}, {"text": "PC", "start": 49, "end": 51}, {"text": "egg-laying hormone", "start": 105, "end": 123}, {"text": "ELH", "start": 125, "end": 128}]}}, "schema": []}
{"input": "Rats treated with 8-OH-DPAT were not impaired in their ability to learn a visual discrimination in a water maze.", "output": {"entities": {}}, "schema": []}
{"input": "The term endovascular papillary haemangioma is suggested.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, two internal promoters, PmiaA and P1hfq were identified and mapped to 201 and 837 nucleotides upstream from the respective translation start sites.", "output": {"entities": {"gene": [{"text": "PmiaA", "start": 37, "end": 42}, {"text": "P1hfq", "start": 47, "end": 52}]}}, "schema": []}
{"input": "These results indicate that mutL, miaA, and hfq expression could be regulated by multiple mechanisms, including degree of cotranscription from upstream genes, modulation of internal promoter strength, and by RNase E activity.", "output": {"entities": {"gene": [{"text": "mutL", "start": 28, "end": 32}, {"text": "miaA", "start": 34, "end": 38}, {"text": "hfq", "start": 44, "end": 47}, {"text": "RNase E", "start": 208, "end": 215}]}}, "schema": []}
{"input": "Coronary T1 and T2 weighted images were obtained.", "output": {"entities": {}}, "schema": []}
{"input": "The 2 kb of 5'-flanking region and the 1. 1 kb of the entire sGTH alpha subunit coding region were sequenced from the genomic clone, sGTH alpha-G1.", "output": {"entities": {"gene": [{"text": "sGTH alpha subunit", "start": 61, "end": 79}, {"text": "sGTH alpha-G1", "start": 133, "end": 146}]}}, "schema": []}
{"input": "Functional analysis of the sGTH alpha subunit promoter by the transient transfection of several sGTH alpha/CAT chimeric plasmids into rainbow trout pituitary cells suggests that its pituitary-specific expression is GSE-dependent.", "output": {"entities": {"gene": [{"text": "sGTH alpha subunit promoter", "start": 27, "end": 54}, {"text": "sGTH alpha", "start": 96, "end": 106}, {"text": "CAT", "start": 107, "end": 110}, {"text": "GSE", "start": 215, "end": 218}]}}, "schema": []}
{"input": "Indium-111 OncoScint CR/OV and F-18 FDG in colorectal and ovarian carcinoma recurrences.", "output": {"entities": {}}, "schema": []}
{"input": "His carnitine palmitoyltransferase (CPT) I and II activities were 0. 06 and 0. 12 nmol/min/mg protein, as compared with a mean value of 0. 22 +/-0. 14 and 0. 27 +/-0. 07 nmol/min/mg protein, respectively, in control subjects.", "output": {"entities": {"gene": [{"text": "carnitine palmitoyltransferase (CPT) I and II", "start": 4, "end": 49}]}}, "schema": []}
{"input": "The Myc LZ was found to prevent homodimeric interactions, thus explaining Myc inability to homodimerize efficiently.", "output": {"entities": {"gene": [{"text": "Myc LZ", "start": 4, "end": 10}, {"text": "Myc", "start": 74, "end": 77}]}}, "schema": []}
{"input": "Thus, VF resistant to defibrillation is not necessarily associated with both toxic plasma drug level and remarkably decreased conduction.", "output": {"entities": {}}, "schema": []}
{"input": "The smallest active FecR derivative contained 59 amino acid residues as compared to the 317 residues of wild-type FecR.", "output": {"entities": {"gene": [{"text": "active FecR derivative", "start": 13, "end": 35}, {"text": "wild-type FecR", "start": 104, "end": 118}]}}, "schema": []}
{"input": "The gene pairs psbB-psbT and psbH-psbN are cotranscribed from opposite strands.", "output": {"entities": {"gene": [{"text": "psbB", "start": 15, "end": 19}, {"text": "psbT", "start": 20, "end": 24}, {"text": "psbH", "start": 29, "end": 33}, {"text": "psbN", "start": 34, "end": 38}]}}, "schema": []}
{"input": "The predicted amino acid sequence contains regions identical to the sequences of peptides derived from bovine liver eIF-2B alpha subunit.", "output": {"entities": {"gene": [{"text": "bovine liver eIF-2B alpha subunit", "start": 103, "end": 136}]}}, "schema": []}
{"input": "Expression of this cDNA in vitro yields a peptide which comigrates with natural eIF-2B alpha in SDS/polyacrylamide gels.", "output": {"entities": {"gene": [{"text": "natural eIF-2B alpha", "start": 72, "end": 92}]}}, "schema": []}
{"input": "When RNA encoding the tail domain of desmoglein was coinjected with plakoglobin RNA, both the dorsalizing effect and nuclear accumulation of plakoglobin were suppressed.", "output": {"entities": {"gene": [{"text": "desmoglein", "start": 37, "end": 47}, {"text": "plakoglobin RNA", "start": 68, "end": 83}, {"text": "plakoglobin", "start": 141, "end": 152}]}}, "schema": []}
{"input": "Six of them, NUC1, PRP21 (also called SPP91), CDC6, CRY2, the gene encoding the ribosomal protein S24 and the gene coding for a hypothetical protein of 599 amino acids, have been sequenced previously.", "output": {"entities": {"gene": [{"text": "NUC1", "start": 13, "end": 17}, {"text": "PRP21", "start": 19, "end": 24}, {"text": "SPP91", "start": 38, "end": 43}, {"text": "CDC6", "start": 46, "end": 50}, {"text": "CRY2", "start": 52, "end": 56}, {"text": "ribosomal protein S24", "start": 80, "end": 101}]}}, "schema": []}
{"input": "Intrastriatal grafts of nigral and adrenal tissues have been found to be effective in alleviating many of the simple motor and sensorimotor deficits associated with lesions of the nigrostriatal dopamine system.", "output": {"entities": {}}, "schema": []}
{"input": "OBJECTIVE: To determine the impact of the introduction of clarithromycin and azithromycin on the treatment and survival of patients with AIDS and disseminated Mycobacterium avium complex (DMAC).", "output": {"entities": {}}, "schema": []}
{"input": "Thereafter, the aggregation rose to the initial 100% value 4 h after drug application and remained at this level during the observation period. (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {}}, "schema": []}
{"input": "Growth curves indicated that proliferation of clone CA9 in the presence of 10% serum was reduced by 60% compared with clone ME10.", "output": {"entities": {}}, "schema": []}
{"input": "The protein coding region, 1, 696 bps long, is divided by an intron into two exons.", "output": {"entities": {}}, "schema": []}
{"input": "The UAS of the AAC2 gene contains at least two distinct motifs for DNA-binding transcriptional activators, including one which is identical with the core HAP2/3/4 binding motif, and a second one with the ABF1 consensus binding sequence.", "output": {"entities": {"gene": [{"text": "AAC2 gene", "start": 15, "end": 24}, {"text": "HAP2/3/4 binding motif", "start": 154, "end": 176}, {"text": "ABF1 consensus binding sequence", "start": 204, "end": 235}]}}, "schema": []}
{"input": "The emerging complexity of the 5' regulatory region of the GH receptor gene was emphasised by the observation that probes derived from exon 1B and the distal 3' intron boundary do not hybridise with previously cloned genomic sequences that span the liver-specific P1 promoter and exon 2.", "output": {"entities": {"gene": [{"text": "GH receptor gene", "start": 59, "end": 75}]}}, "schema": []}
{"input": "A polymorphic dinucleotide (GT/CA) n repeat contained in the NHE5 cosmid was identified and developed into a microsatellite PCR marker.", "output": {"entities": {}}, "schema": []}
{"input": "The proteins are more than 90% identical to each other within the protein kinase domain but only 51-59% identical to other casein kinase I isoforms within this region.", "output": {"entities": {"gene": [{"text": "casein kinase I isoforms", "start": 123, "end": 147}]}}, "schema": []}
{"input": "We used two approaches to ascertain whether CDP/cut serves as a repressor of gp91-phox gene expression.", "output": {"entities": {"gene": [{"text": "CDP", "start": 44, "end": 47}, {"text": "cut", "start": 48, "end": 51}, {"text": "gp91", "start": 77, "end": 81}, {"text": "phox", "start": 82, "end": 86}]}}, "schema": []}
{"input": "Despite the activation of these intracellular signaling molecules, PDGF beta receptor activation elicited no detectable effect on cell proliferation or differentiation.", "output": {"entities": {"gene": [{"text": "PDGF beta receptor", "start": 67, "end": 85}]}}, "schema": []}
{"input": "UAS1 is the binding site for the transcriptional regulator Adr1p.", "output": {"entities": {"gene": [{"text": "Adr1p", "start": 59, "end": 64}]}}, "schema": []}
{"input": "In the context of the ADH2 upstream regulatory region, including UAS1, working in concert with the ADH2 basal promoter elements, UAS2-dependent gene activation was dependent on orientation, copy number, and helix phase.", "output": {"entities": {"gene": [{"text": "ADH2 upstream regulatory region", "start": 22, "end": 53}, {"text": "ADH2 basal promoter elements", "start": 99, "end": 127}]}}, "schema": []}
{"input": "Induction in AP-1 DNA binding correlates with a concomitant GH trans-activation of c-jun and c-fos genes described previously.", "output": {"entities": {"gene": [{"text": "AP-1", "start": 13, "end": 17}, {"text": "GH", "start": 60, "end": 62}, {"text": "c-jun", "start": 83, "end": 88}, {"text": "c-fos genes", "start": 93, "end": 104}]}}, "schema": []}
{"input": "Inactivation of MAP kinases occurs via a specific phosphatase, MKP-1.", "output": {"entities": {"gene": [{"text": "MAP kinases", "start": 16, "end": 27}, {"text": "MKP-1", "start": 63, "end": 68}]}}, "schema": []}
{"input": "Short-course amphotericin B therapy for candidemia in pediatric patients.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, 45Ca-binding assays revealed that CCaMK directly binds Ca2 +.", "output": {"entities": {"gene": [{"text": "CCaMK", "start": 47, "end": 52}]}}, "schema": []}
{"input": "The protein expressed from the cloned cDNA is secreted into the culture medium and yields of up to 40 mg per litre have been obtained.", "output": {"entities": {}}, "schema": []}
{"input": "Plasmids pAMS12, pAMS13 and pAMS14 were transformed into a laboratory strain of Saccharomyces cerevisiae, whereas pAMS15 was stably introduced into two commercial wine yeast strains.", "output": {"entities": {}}, "schema": []}
{"input": "The maximum induction of ACC-oxidase transcripts occurred at about 6 h after excision, while the maximum enzyme activity was observed at 24 h.", "output": {"entities": {"gene": [{"text": "ACC-oxidase transcripts", "start": 25, "end": 48}]}}, "schema": []}
{"input": "Within their polypeptide chain, they all contain those conserved features that define a plant CDPK; kinase catalytic sequences are linked to a calmodulin-like regulatory domain through a junction region.", "output": {"entities": {"gene": [{"text": "CDPK", "start": 94, "end": 98}, {"text": "calmodulin-like regulatory domain", "start": 143, "end": 176}]}}, "schema": []}
{"input": "Repair of this insertion by homologous recombination restores the activity of the hprt locus, thus confirming the site of mutation.", "output": {"entities": {"gene": [{"text": "hprt locus", "start": 82, "end": 92}]}}, "schema": []}
{"input": "The timing of fla gene expression in the cell cycle is determined by specialized forms of RNA polymerase and the appearance and/or activation of regulatory proteins.", "output": {"entities": {"gene": [{"text": "fla gene", "start": 14, "end": 22}, {"text": "RNA polymerase", "start": 90, "end": 104}]}}, "schema": []}
{"input": "Primer extension experiments revealed a strong transcription initiation site 102 bp upstream of the translational start site.", "output": {"entities": {}}, "schema": []}
{"input": "Polypeptides of the same apparent sizes are detected in spores of a cotE null mutant, on which basis we infer that the products of the cotJ operon are required for the normal formation of the inner layers of the coat or are themselves structural components of the coat.", "output": {"entities": {"gene": [{"text": "cotE", "start": 68, "end": 72}, {"text": "cotJ operon", "start": 135, "end": 146}]}}, "schema": []}
{"input": "Based on the estimated values of divergence of apobec1 sequences in terms of the numbers of synonymous and non-synonymous suhstitutions per site, we found that apobec1 is a fairly rapidly evolving protein.", "output": {"entities": {"gene": [{"text": "apobec1 sequences", "start": 47, "end": 64}, {"text": "apobec1", "start": 160, "end": 167}]}}, "schema": []}
{"input": "EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine \" fingers \" and contains a calmodulin-binding IQ motif.", "output": {"entities": {"gene": [{"text": "EEA1", "start": 0, "end": 4}, {"text": "calmodulin-binding IQ motif", "start": 109, "end": 136}]}}, "schema": []}
{"input": "Nucleotide sequences of the clones revealed that one clone, cap3, contained an open reading frame (ORF) that would code for a 26-amino acid, cysteine-rich peptide with significant homology to Neurospora crassa copper metallothionein.", "output": {"entities": {"gene": [{"text": "cap3", "start": 60, "end": 64}, {"text": "Neurospora crassa copper metallothionein", "start": 192, "end": 232}]}}, "schema": []}
{"input": "Sensing with chemically and biologically modified carbon electrodes.", "output": {"entities": {}}, "schema": []}
{"input": "Elevation of the tissues of the face is essentially vertical and acts on the forehead, temporal region, gaze and cheekbones.", "output": {"entities": {}}, "schema": []}
{"input": "This region binds two ubiquitous nuclear factors, USF/MLTF and the CAAT-binding transcription factor/nuclear factor 1 (CTF/NF1).", "output": {"entities": {"gene": [{"text": "USF", "start": 50, "end": 53}, {"text": "MLTF", "start": 54, "end": 58}, {"text": "CAAT-binding transcription factor", "start": 67, "end": 100}, {"text": "nuclear factor 1", "start": 101, "end": 117}, {"text": "CTF", "start": 119, "end": 122}, {"text": "NF1", "start": 123, "end": 126}]}}, "schema": []}
{"input": "The potential impact of using a rapid diagnostic test (Strep A OIA) on detection and treatment of group A beta-hemolytic streptococcal (GABHS) pharyngitis in a large-volume pediatric and adolescent clinic was examined.", "output": {"entities": {}}, "schema": []}
{"input": "The bHLH proteins function as potent transcriptional activators of tissue-specific genes by forming heterodimers between ubiquitous and cell-restricted family members.", "output": {"entities": {"gene": [{"text": "bHLH proteins", "start": 4, "end": 17}]}}, "schema": []}
{"input": "YAC and cosmid contigs spanning the BRCA1 region were used to select cDNA clones from pools of cDNAs derived from human placenta, HeLa cells, activated T cells, and fetal head.", "output": {"entities": {"gene": [{"text": "BRCA1 region", "start": 36, "end": 48}]}}, "schema": []}
{"input": "This study assesses the feasibility and toxicity of adoptive immunotherapy with tumor infiltrating lymphocytes and recombinant interleukin-2 in 29 patients who underwent resection for stage III non-small-cell lung cancer.", "output": {"entities": {"gene": [{"text": "recombinant interleukin-2", "start": 115, "end": 140}]}}, "schema": []}
{"input": "The present study describes the cell volume dynamics in intact rat hearts, during ischemia and after reperfusion.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast, COUP-TF alone had no effect on repCRS2-dependent reporter gene activity.", "output": {"entities": {"gene": [{"text": "COUP-TF", "start": 13, "end": 20}]}}, "schema": []}
{"input": "DNA sequencing and Southern blot analyses established that the cDNA clones are derived from two different genes.", "output": {"entities": {}}, "schema": []}
{"input": "Mutation of the Sp1 element, which abolishes Sp1 binding, results in a 6-10-fold reduction in reporter activity.", "output": {"entities": {"gene": [{"text": "Sp1 element", "start": 16, "end": 27}, {"text": "Sp1", "start": 45, "end": 48}]}}, "schema": []}
{"input": "The c-myc gene is overexpressed in a variety of tumor types and appears to play an important role in the abnormal growth of a number of cell types.", "output": {"entities": {"gene": [{"text": "c-myc gene", "start": 4, "end": 14}]}}, "schema": []}
{"input": "Schooling is found to be related to good health even after controlling for differences in observable health inputs.", "output": {"entities": {}}, "schema": []}
{"input": "With this bisected diastolic driving, the abnormal echo disappeared completely.", "output": {"entities": {}}, "schema": []}
{"input": "It acts on Cdks in the G1 and S phases of the cell cycle, and also binds to proliferating cell nuclear antigen (PCNA), blocking DNA replication in vitro.", "output": {"entities": {"gene": [{"text": "Cdks", "start": 11, "end": 15}, {"text": "proliferating cell nuclear antigen", "start": 76, "end": 110}, {"text": "PCNA", "start": 112, "end": 116}]}}, "schema": []}
{"input": "Two major and one minor transcription initiation sites were assigned to positions + 1 and + 24 and position + 14, respectively, by a combination of ribonuclease protection, primer extension, and 5' RACE analyses.", "output": {"entities": {}}, "schema": []}
{"input": "Further, the ORFs of components 3 and 5 potentially encoded proteins of about 20 kDa, the size of the BBTV coat protein.", "output": {"entities": {"gene": [{"text": "BBTV coat protein", "start": 102, "end": 119}]}}, "schema": []}
{"input": "CodY does not have any homologues in the data-bases.", "output": {"entities": {"gene": [{"text": "CodY", "start": 0, "end": 4}]}}, "schema": []}
{"input": "OBJECTIVE: To investigate the incidence and presentation of acute pernicious or fulminating beriberi in a general district hospital.", "output": {"entities": {}}, "schema": []}
{"input": "Unlike most other small G proteins which are expressed ubiquitously, TTF was transcribed only in hemopoietic cells as a 2. 2 kb transcript.", "output": {"entities": {"gene": [{"text": "small G proteins", "start": 18, "end": 34}, {"text": "TTF", "start": 69, "end": 72}]}}, "schema": []}
{"input": "An explanation explored for this lack of gene expression was that increased levels of RAR alpha or PML might suppress APL cell growth.", "output": {"entities": {"gene": [{"text": "RAR alpha", "start": 86, "end": 95}, {"text": "PML", "start": 99, "end": 102}]}}, "schema": []}
{"input": "Cytosolic extracts from a variety of mammalian cell lines (monkey Cos7, several mouse fibrosarcomas and human HeLa S3) demonstrated similar TGF-beta 1 dependent RNA-protein band shifts as cell extract from BALB/c 3T3 mouse fibroblasts.", "output": {"entities": {"gene": [{"text": "TGF-beta 1", "start": 140, "end": 150}]}}, "schema": []}
{"input": "The provisional reports are based mainly upon macroscopic findings, whereas the final reports include the information provided by supplementary investigations such as microscopy, histochemistry, more rarely electron microscopy, immunohistochemistry and/or microbiology.", "output": {"entities": {}}, "schema": []}
{"input": "Circulating thrombomodulin: current knowledge and future prospects", "output": {"entities": {"gene": [{"text": "thrombomodulin", "start": 12, "end": 26}]}}, "schema": []}
{"input": "CPT-11 was administered as a 30-minute i. v. infusion at a dose of 350 mg/m2 diluted in 250 ml normal saline every 3 weeks.", "output": {"entities": {}}, "schema": []}
{"input": "A 73 bp fragment (X1 region) of the PRB-1b promoter, located between positions-213 and-141, was sufficient to confer ethylene responsiveness to the reporter gene.", "output": {"entities": {"gene": [{"text": "PRB-1b promoter", "start": 36, "end": 51}]}}, "schema": []}
{"input": "To assess the function (s) of E74 during metamorphosis, we have isolated and characterized recessive loss-of-function mutations specific to each transcription unit.", "output": {"entities": {"gene": [{"text": "E74", "start": 30, "end": 33}]}}, "schema": []}
{"input": "Although the extracellular domain of the TSH-R is sufficient for high affinity binding of TSH, we conclude that the hyt mutation in the fourth transmembrane domain eliminates TSH binding.", "output": {"entities": {"gene": [{"text": "TSH-R", "start": 41, "end": 46}, {"text": "TSH", "start": 90, "end": 93}, {"text": "TSH", "start": 175, "end": 178}]}}, "schema": []}
{"input": "Lipiodol was covalently conjugated with EDTB.", "output": {"entities": {}}, "schema": []}
{"input": "Moreover, Western blots demonstrated at least six types of Ypt in both Cr and Vc, suggesting that these Ypt are used for household functions responsible for vesicle transport rather than for cellular differentiation.", "output": {"entities": {"gene": [{"text": "Ypt", "start": 59, "end": 62}, {"text": "Ypt", "start": 104, "end": 107}]}}, "schema": []}
{"input": "The absence of other regions of hybridization suggests that there are no closely related sequences (e. g., reverse transcribed pseudogenes) scattered throughout the genome and that if there are closely related genes, they must be clustered near GSTT2.", "output": {"entities": {"gene": [{"text": "GSTT2", "start": 245, "end": 250}]}}, "schema": []}
{"input": "However, the lens dose (3. 6 Gy/25 fractions) was higher compared to the other techniques.", "output": {"entities": {}}, "schema": []}
{"input": "Antibodies to the human PTS1R recognize this protein in human, monkey, rat, and hamster cells.", "output": {"entities": {"gene": [{"text": "human PTS1R", "start": 18, "end": 29}]}}, "schema": []}
{"input": "There is a national effort to begin to ask all female patients about family violence.", "output": {"entities": {}}, "schema": []}
{"input": "GnRH treatment was found to increase the phosphorylation of tyrosine residues of MAPK and to increase MAPK activity, as determined by an immune complex kinase assay.", "output": {"entities": {"gene": [{"text": "GnRH", "start": 0, "end": 4}, {"text": "MAPK", "start": 81, "end": 85}, {"text": "MAPK", "start": 102, "end": 106}]}}, "schema": []}
{"input": "Molecular cloning of an amphibian insulin receptor substrate 1-like cDNA and involvement of phosphatidylinositol 3-kinase in insulin-induced Xenopus oocyte maturation.", "output": {"entities": {"gene": [{"text": "amphibian insulin receptor substrate 1-like cDNA", "start": 24, "end": 72}, {"text": "phosphatidylinositol 3-kinase", "start": 92, "end": 121}, {"text": "insulin", "start": 125, "end": 132}]}}, "schema": []}
{"input": "We report here that in cultured Jurkat T cells, Cbl is coprecipitated with antibody against the adapter protein Grb2.", "output": {"entities": {"gene": [{"text": "Cbl", "start": 48, "end": 51}, {"text": "adapter protein Grb2", "start": 96, "end": 116}]}}, "schema": []}
{"input": "The effect of these cell cycle regulators is not specific to the rap1s or hmr delta A mutation, since swi6, swi4, and clb5 mutations also suppress mutations in SIR1, another gene implicated in the establishment of silencing.", "output": {"entities": {"gene": [{"text": "rap1s", "start": 65, "end": 70}, {"text": "hmr delta A mutation", "start": 74, "end": 94}, {"text": "swi6", "start": 102, "end": 106}, {"text": "swi4", "start": 108, "end": 112}, {"text": "clb5 mutations", "start": 118, "end": 132}, {"text": "SIR1", "start": 160, "end": 164}]}}, "schema": []}
{"input": "ICP4 has been shown to form tripartite complexes cooperatively with the TATA box-binding protein and TFIIB on DNA containing an ICP4 binding site and a TATA box (C.", "output": {"entities": {"gene": [{"text": "ICP4", "start": 0, "end": 4}, {"text": "TATA box-binding protein", "start": 72, "end": 96}, {"text": "TFIIB", "start": 101, "end": 106}, {"text": "ICP4 binding site", "start": 128, "end": 145}]}}, "schema": []}
{"input": "Characterization of fus1 of Schizosaccharomyces pombe: a developmentally controlled function needed for conjugation.", "output": {"entities": {"gene": [{"text": "fus1", "start": 20, "end": 24}]}}, "schema": []}
{"input": "SRY-related cDNA encoding a protein with a high-mobility-group (HMG) box and a leucine zipper motif, which was designated SOX-LZ, was isolated from a rainbow trout testis cDNA library.", "output": {"entities": {"gene": [{"text": "SRY-related cDNA", "start": 0, "end": 16}, {"text": "high-mobility-group", "start": 43, "end": 62}, {"text": "HMG", "start": 64, "end": 67}, {"text": "SOX-LZ", "start": 122, "end": 128}]}}, "schema": []}
{"input": "Scalp flaps can be expanded just to the point of becoming noticeable over 4 to 6 weeks followed by scalp flap transposition and easy closure of the donor site.", "output": {"entities": {}}, "schema": []}
{"input": "In the Center for Human Genetics in Leuven, predictive DNA-testing for Huntington' s disease is available as a clinical service since November 1987, initially by DNA-linkage and since mid 1993 by direct mutation analysis.", "output": {"entities": {}}, "schema": []}
{"input": "Risks of chronicity following acute hepatitis B virus infection: a review.", "output": {"entities": {}}, "schema": []}
{"input": "Examination of neurohumoral factors revealed a hyperactive sympathetic nervous system and an increase in plasma renin activity.", "output": {"entities": {"gene": [{"text": "renin", "start": 112, "end": 117}]}}, "schema": []}
{"input": "We compared the inhibitory effect of naturally occurring mutant hTR beta 1, artificially created hTR alpha 1 mutants, c-erbA alpha 2 and the human peroxisome proliferator-activated receptor (hPPAR) on three prototypic T3-response elements (TREs), TRE-PAL, DR + 4 and TRE-LAP.", "output": {"entities": {"gene": [{"text": "mutant hTR beta 1", "start": 57, "end": 74}, {"text": "hTR alpha 1 mutants", "start": 97, "end": 116}, {"text": "c-erbA alpha 2", "start": 118, "end": 132}, {"text": "human peroxisome proliferator-activated receptor", "start": 141, "end": 189}, {"text": "hPPAR", "start": 191, "end": 196}]}}, "schema": []}
{"input": "The amino-terminal DNA-binding domain of Pip exhibits a high degree of homology to the DNA-binding domains of members of the interferon regulatory factor (IRF) family, which includes IRF-1, IRF-2, ICSBP, and ISGF3 gamma.", "output": {"entities": {"gene": [{"text": "Pip", "start": 41, "end": 44}, {"text": "interferon regulatory factor", "start": 125, "end": 153}, {"text": "IRF", "start": 155, "end": 158}, {"text": "IRF-1", "start": 183, "end": 188}, {"text": "IRF-2", "start": 190, "end": 195}, {"text": "ICSBP", "start": 197, "end": 202}, {"text": "ISGF3 gamma", "start": 208, "end": 219}]}}, "schema": []}
{"input": "An outbreak of hepatitis A among homosexual men in Amsterdam, 1991-1993.", "output": {"entities": {}}, "schema": []}
{"input": "The RAP74 subunit of TFIIF alone contained the stimulatory activity and the minimal region sufficient for stimulation corresponds to COOH-terminal residues 358-517.", "output": {"entities": {"gene": [{"text": "RAP74 subunit", "start": 4, "end": 17}, {"text": "TFIIF", "start": 21, "end": 26}]}}, "schema": []}
{"input": "We have generated various base substitutions and internal deletions in and around DRE (nucleotide positions-93 to-100 with respect to the transcription initiation site) of the PCNA gene in vitro and subsequently examined their effects on the binding to DREF (DRE-binding factor) and PCNA gene promote activity in cultured Drosophila Kc cells as well as in living flies.", "output": {"entities": {"gene": [{"text": "PCNA gene", "start": 176, "end": 185}, {"text": "DREF", "start": 253, "end": 257}, {"text": "DRE-binding factor", "start": 259, "end": 277}, {"text": "PCNA gene", "start": 283, "end": 292}]}}, "schema": []}
{"input": "The hsp70 gene family of Neurospora crassa: cloning, sequence analysis, expression, and genetic mapping of the major stress-inducible member.", "output": {"entities": {"gene": [{"text": "hsp70 gene family", "start": 4, "end": 21}]}}, "schema": []}
{"input": "The deduced amino acid sequences of each of the W3A1 ETF subunits exhibit only approximately 30% identity with the corresponding subunits of the ETF from human, rat, and Paracoccus denitrificans, which as a group are greater than 50% identical.", "output": {"entities": {"gene": [{"text": "W3A1 ETF subunits", "start": 48, "end": 65}, {"text": "ETF", "start": 145, "end": 148}]}}, "schema": []}
{"input": "This last region contains two sites that bind Ets-related proteins present in liver nuclear extracts as well as recombinant purified Ets-1 protein.", "output": {"entities": {"gene": [{"text": "Ets-related proteins", "start": 46, "end": 66}, {"text": "recombinant purified Ets-1 protein", "start": 112, "end": 146}]}}, "schema": []}
{"input": "Other assays also distinguished the processive replication of pNeo. Myc-2. 4 from the dispersive labeling of control plasmids.", "output": {"entities": {}}, "schema": []}
{"input": "Therefore, it is hoped that by defining the transcriptional control of the L7 gene insights into the mechanisms that control functional fate and organization in the nervous system can be gained.", "output": {"entities": {"gene": [{"text": "L7 gene", "start": 75, "end": 82}]}}, "schema": []}
{"input": "In contrast, a Maf-related protein, Nrl, completely mimicked c-Maf actions.", "output": {"entities": {"gene": [{"text": "Maf-related protein", "start": 15, "end": 34}, {"text": "Nrl", "start": 36, "end": 39}, {"text": "c-Maf", "start": 61, "end": 66}]}}, "schema": []}
{"input": "The 27-base element interacts with a PDGF-activated serine/threonine phosphoprotein that is detected only within the nucleus of PDGF-treated 3T3 cells.", "output": {"entities": {"gene": [{"text": "PDGF", "start": 37, "end": 41}]}}, "schema": []}
{"input": "By contrast, deletion of this Ras-binding site did not diminish activation of Raf-1 kinase by Src, implying that Src and Ras can activate Raf-1 through independent mechanisms.", "output": {"entities": {"gene": [{"text": "Ras-binding site", "start": 30, "end": 46}, {"text": "Raf-1 kinase", "start": 78, "end": 90}, {"text": "Src", "start": 94, "end": 97}, {"text": "Src", "start": 113, "end": 116}, {"text": "Ras", "start": 121, "end": 124}, {"text": "Raf-1", "start": 138, "end": 143}]}}, "schema": []}
{"input": "In studies of many different phenotypically distinct cells, the CRE of the somatostatin gene promoter is a prototype of a highly cAMP-responsive element regulated by CREB.", "output": {"entities": {"gene": [{"text": "somatostatin gene promoter", "start": 75, "end": 101}, {"text": "CREB", "start": 166, "end": 170}]}}, "schema": []}
{"input": "The first gene, NSR1, a previously identified gene, encodes a protein involved in ribosomal RNA maturation and possibly in transport of proteins into the nucleus.", "output": {"entities": {"gene": [{"text": "NSR1", "start": 16, "end": 20}]}}, "schema": []}
{"input": "Characterization of the promoter for the human 85 kDa cytosolic phospholipase A2 gene.", "output": {"entities": {"gene": [{"text": "human 85 kDa cytosolic phospholipase A2 gene", "start": 41, "end": 85}]}}, "schema": []}
{"input": "This paper describes the advantages and limitations of the main study approaches used.", "output": {"entities": {}}, "schema": []}
{"input": "Comparative study of the differential white blood cell count using three automated analyzers: Coulter STKS, Sysmex NE 8000 and Technicon H-1.", "output": {"entities": {}}, "schema": []}
{"input": "Characterization of FIII/YY1, a Xenopus laevis conserved zinc-finger protein binding to the first exon of L1 and L14 ribosomal protein genes.", "output": {"entities": {"gene": [{"text": "FIII", "start": 20, "end": 24}, {"text": "YY1", "start": 25, "end": 28}, {"text": "Xenopus laevis conserved zinc-finger protein", "start": 32, "end": 76}, {"text": "L1", "start": 106, "end": 108}, {"text": "L14 ribosomal protein genes", "start": 113, "end": 140}]}}, "schema": []}
{"input": "Further studies established that the Ep-induced increase in beta-globin mRNA could be inhibited by the tyrosine kinase inhibitor genistein and the protein kinase C inhibitor Compound 3. (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {"gene": [{"text": "Ep", "start": 37, "end": 39}, {"text": "beta-globin mRNA", "start": 60, "end": 76}, {"text": "tyrosine kinase", "start": 103, "end": 118}, {"text": "protein kinase C", "start": 147, "end": 163}]}}, "schema": []}
{"input": "This structure of cucumisin suggests that it is probably synthesized as an inactive precursor.", "output": {"entities": {"gene": [{"text": "cucumisin", "start": 18, "end": 27}]}}, "schema": []}
{"input": "Molecular dissection of the multimeric CD3-TCR complex revealed that at least two associated polypeptides, CD3 zeta and CD3 epsilon, autonomously couple antigenic recognition event to early and late events of the intracytoplasmic activation cascade.", "output": {"entities": {"gene": [{"text": "CD3", "start": 39, "end": 42}, {"text": "TCR", "start": 43, "end": 46}, {"text": "CD3 zeta", "start": 107, "end": 115}, {"text": "CD3 epsilon", "start": 120, "end": 131}]}}, "schema": []}
{"input": "This study investigated the degree to which racial identity influences Mexican-Americans' performance on the L, K, and MF scales of the MMPI-2.", "output": {"entities": {}}, "schema": []}
{"input": "Both can be elevated on a single vascular pedicle based on the superficial temporal artery, the double-layered temporal fascia flap.", "output": {"entities": {}}, "schema": []}
{"input": "To do this, segments of DNA from the 5' flank of the initiation sites for germline epsilon RNA were ligated to a luciferase reporter gene and transfected into two mouse B cell lines, one of which can be induced to switch to IgE.", "output": {"entities": {"gene": [{"text": "luciferase reporter gene", "start": 113, "end": 137}, {"text": "IgE", "start": 224, "end": 227}]}}, "schema": []}
{"input": "The negative predictive value is 92%, vs 80% for the NCEP I.", "output": {"entities": {}}, "schema": []}
{"input": "Oncogenic capacity of the E2F1 gene.", "output": {"entities": {"gene": [{"text": "E2F1 gene", "start": 26, "end": 35}]}}, "schema": []}
{"input": "In some of the cases of solitary lesion, serum TSH levels, serum thyroglobulin values, and 131I protein bounded iodine (131I-PBI) were measured, but there were no significant differences between successful and unsuccessful therapy.", "output": {"entities": {"gene": [{"text": "serum TSH", "start": 41, "end": 50}, {"text": "serum thyroglobulin", "start": 59, "end": 78}]}}, "schema": []}
{"input": "Endo16 transcripts are confined to the definitive vegetal plate in blastula stage embryos; at gastrula stage this gene is expressed throughout the archenteron, but later only in the midgut.", "output": {"entities": {"gene": [{"text": "Endo16 transcripts", "start": 0, "end": 18}]}}, "schema": []}
{"input": "A unique leucine-proline repeat element found N-terminal to the DNA-binding domain of EmBP-1 does not appear to play a role in DNA-binding or dimerization.", "output": {"entities": {"gene": [{"text": "EmBP-1", "start": 86, "end": 92}]}}, "schema": []}
{"input": "Another full ORF was found on the opposite strand downstream from the nspC gene.", "output": {"entities": {"gene": [{"text": "nspC gene", "start": 70, "end": 79}]}}, "schema": []}
{"input": "Two related cDNAs were isolated that encode proteins that recognize the XMyoDa TATA motif.", "output": {"entities": {"gene": [{"text": "XMyoDa TATA motif", "start": 72, "end": 89}]}}, "schema": []}
{"input": "Deletion of both prfA and ponA resulted in extremely slow growth and a reduction in sporulation efficiency.", "output": {"entities": {"gene": [{"text": "prfA", "start": 17, "end": 21}, {"text": "ponA", "start": 26, "end": 30}]}}, "schema": []}
{"input": "In broken L-cell membranes expressing wild type or mutant M6P/IGF II receptors, 30 nM IGF II also failed to affect the pertussis toxin substrate activity.", "output": {"entities": {"gene": [{"text": "mutant M6P/IGF II receptors", "start": 51, "end": 78}, {"text": "IGF II", "start": 86, "end": 92}, {"text": "pertussis toxin", "start": 119, "end": 134}]}}, "schema": []}
{"input": "Chem.", "output": {"entities": {}}, "schema": []}
{"input": "For the first time we describe deletion and point mutations within the plasma membrane family of guanylyl cyclase receptors that result in the formation of effective dominant negative proteins.", "output": {"entities": {"gene": [{"text": "plasma membrane family of guanylyl cyclase receptors", "start": 71, "end": 123}]}}, "schema": []}
{"input": "Increase in blood NEFA was further augmented by fat plus AA supplementation, but no changes in concentrations of Lys or Met in blood were found.", "output": {"entities": {}}, "schema": []}
{"input": "Virol.", "output": {"entities": {}}, "schema": []}
{"input": "Comparison of the deduced amino acid sequence of gamma-kafirin with the published sequences of gamma-prolamins of maize, and Coix revealed highly conserved domains.", "output": {"entities": {"gene": [{"text": "amino acid sequence of gamma-kafirin", "start": 26, "end": 62}, {"text": "sequences of gamma-prolamins of maize, and Coix", "start": 82, "end": 129}]}}, "schema": []}
{"input": "These results suggest that HAC1 may also be one of the meiotic genes.", "output": {"entities": {"gene": [{"text": "HAC1", "start": 27, "end": 31}]}}, "schema": []}
{"input": "We characterized three Arabidopsis thaliana cDNA clones that could rescue the sterile phenotype of the Schizosaccharomyces pombe pde1 mutant, which is defective in cAMP phosphodiesterase.", "output": {"entities": {"gene": [{"text": "Schizosaccharomyces pombe pde1 mutant", "start": 103, "end": 140}, {"text": "cAMP phosphodiesterase", "start": 164, "end": 186}]}}, "schema": []}
{"input": "Furthermore, the identification of a Dr1-like protein in A. thaliana strongly argues for the ubiquity of this protein among eukaryotic genera and for a conserved mechanism to regulate transcription initiation that involves Dr1.", "output": {"entities": {"gene": [{"text": "Dr1-like protein", "start": 37, "end": 53}, {"text": "Dr1", "start": 223, "end": 226}]}}, "schema": []}
{"input": "Similarly approximately 300 bp of sequence downstream of the translation terminator TGA of the beta-tubulin 2 (BTU2) gene could substitute for the 3' region of the H4-I gene.", "output": {"entities": {"gene": [{"text": "beta-tubulin 2", "start": 95, "end": 109}, {"text": "BTU2", "start": 111, "end": 115}, {"text": "H4-I gene", "start": 164, "end": 173}]}}, "schema": []}
{"input": "These data demonstrate that the STR family of genes is represented in a nematode whose ancestor appeared well before the branching that gave rise to the Arthropoda and Chordata.", "output": {"entities": {"gene": [{"text": "STR family", "start": 32, "end": 42}]}}, "schema": []}
{"input": "The pre-and postoperative haemoglobin concentrations in the autologous group were lower by 15 and 10 g/L, respectively, after primary THR and by 10 g/L in both instances after revision THR.", "output": {"entities": {"gene": [{"text": "haemoglobin", "start": 26, "end": 37}]}}, "schema": []}
{"input": "The introduction of an acidic residue at the second site was essential for suppression of the Asn-285 mutation because Lys-220 and Gln-220 second-site mutants of the Asn-285 mutant showed very low tetracycline resistance. (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {}}, "schema": []}
{"input": "Tumor necrosis factor alpha, the cytokine that participates in the autocrine growth control of hairy cell leukemia has strong bone resorptive properties.", "output": {"entities": {"gene": [{"text": "Tumor necrosis factor alpha", "start": 0, "end": 27}]}}, "schema": []}
{"input": "(iv) Although UCRBP has been previously shown to act as a transcriptional repressor, we show here that UCRBP can also act as a positive transactivator of a reporter driven by UCR elements when used in co-transfection assays.", "output": {"entities": {"gene": [{"text": "UCRBP", "start": 14, "end": 19}, {"text": "UCRBP", "start": 103, "end": 108}]}}, "schema": []}
{"input": "The sequence of monkey opsin closely resembles the human sequence at the nucleotide and the amino acid levels, with the latter having only 7 differences out of 348 residues.", "output": {"entities": {"gene": [{"text": "monkey opsin", "start": 16, "end": 28}]}}, "schema": []}
{"input": "One complex appears to be ubiquitous but enriched in lymphoid cells and represents the binding of a potentially novel factor with an apparent molecular mass of approximately 50 kDa.", "output": {"entities": {}}, "schema": []}
{"input": "Chem.", "output": {"entities": {}}, "schema": []}
{"input": "Conversely, activation of Oct-3/4 promoter by RAR: RXR heterodimers was completely abolished by EAR-3/COUP-TFI and by ARP-1/COUP-TFII.", "output": {"entities": {"gene": [{"text": "Oct-3/4 promoter", "start": 26, "end": 42}, {"text": "RAR", "start": 46, "end": 49}, {"text": "RXR heterodimers", "start": 51, "end": 67}, {"text": "EAR-3", "start": 96, "end": 101}, {"text": "COUP-TFI", "start": 102, "end": 110}, {"text": "ARP-1", "start": 118, "end": 123}, {"text": "COUP-TFII", "start": 124, "end": 133}]}}, "schema": []}
{"input": "These results demonstrate that EKLF provides a crucial transactivation function for globin expression and further reinforce the idea that EKLF is an important regulator of CACCC element-directed transcription in erythroid cells.", "output": {"entities": {"gene": [{"text": "EKLF", "start": 31, "end": 35}, {"text": "globin", "start": 84, "end": 90}, {"text": "EKLF", "start": 138, "end": 142}]}}, "schema": []}
{"input": "Using a battery of I kappa B alpha mutants, we show that (i) a dimer binds a single I kappa B alpha molecule, (ii) the acidic C-terminal region of I kappa B alpha is not required for protein-protein binding and does not mask the nuclear localization signal of the dimer, (iii) the same C-terminal region is required for inhibition of DNA binding, and (iv) this inhibition may be accomplished by direct interaction between the PEST-like region and the DNA-binding region of one of the subunits of the dimer.", "output": {"entities": {"gene": [{"text": "I kappa B alpha mutants", "start": 19, "end": 42}, {"text": "I kappa B alpha molecule", "start": 84, "end": 108}, {"text": "I kappa B alpha", "start": 147, "end": 162}]}}, "schema": []}
{"input": "The negative regulatory activity of the N-terminal domain was antagonized by a C-terminal segment of Pho81p supplied in trans.", "output": {"entities": {"gene": [{"text": "Pho81p", "start": 101, "end": 107}]}}, "schema": []}
{"input": "At different times of the surgical procedures (thorax opening and closure, period of cardiopulmonary bypass) 67 to 100% of the patients in group 1 had vancomycin concentrations in the studied tissues above the MIC 90 for Staphylococcus aureus (1 microgram/g) and Staphylococcus epidermidis (2 micrograms/g).", "output": {"entities": {}}, "schema": []}
{"input": "On-line angioscopic images of tissue flaps floating in the lumen, recent or structured thrombi, artery wall dissections, plaque ruptures, deep fissurations and sub-intimal haemorrhages demonstrate, in live colour, the pathophysiological mechanisms of coronary artery stenosis.", "output": {"entities": {}}, "schema": []}
{"input": "The enhanced cysteine formation in a pCSK4F plant responding to sulfite was also observed in leaf discs.", "output": {"entities": {}}, "schema": []}
{"input": "Each type was divided into two subgroups on the basis of whether the body and tail of the pancreas showed intense fatty replacement (type a = negative for intense fatty replacement, type b = positive for intense fatty replacement).", "output": {"entities": {}}, "schema": []}
{"input": "A new hypothesis on mechanisms for inhibiting catalytic subunits by gamma-subunits and activation of a holoenzyme by transducin", "output": {"entities": {}}, "schema": []}
{"input": "Binding of SSP to the stage selector element (SSE) in the proximal gamma-globin promoter is integral to the competitive silencing of a linked beta-promoter in embryonic/fetal stage erythroleukemia (K562) cells.", "output": {"entities": {"gene": [{"text": "SSP", "start": 11, "end": 14}, {"text": "stage selector element", "start": 22, "end": 44}, {"text": "SSE", "start": 46, "end": 49}, {"text": "gamma-globin promoter", "start": 67, "end": 88}, {"text": "beta-promoter", "start": 142, "end": 155}]}}, "schema": []}
{"input": "This failure to execute regulated G1/S arrest is correlated with enhanced thermosensitivity of colony-forming ability.", "output": {"entities": {}}, "schema": []}
{"input": "Mutations that alter photoreceptor cell structure and development were isolated that fail to complement these deletions.", "output": {"entities": {}}, "schema": []}
{"input": "It is possible that the telomeres of the two nuclei have different functions.", "output": {"entities": {}}, "schema": []}
{"input": "The marker orders from the genetic and RH maps were consistent.", "output": {"entities": {}}, "schema": []}
{"input": "Integrated mapping analysis of the Werner syndrome region of chromosome 8.", "output": {"entities": {}}, "schema": []}
{"input": "The region between DXS52 and Factor VIII gene in the human Xq28 chromosomal band contains a G + C-rich isochore to which many genes have been mapped.", "output": {"entities": {"gene": [{"text": "DXS52", "start": 19, "end": 24}, {"text": "Factor VIII gene", "start": 29, "end": 45}]}}, "schema": []}
{"input": "Haplotype mapping and sequence analysis of the mouse Nramp gene predict susceptibility to infection with intracellular parasites.", "output": {"entities": {"gene": [{"text": "Nramp gene", "start": 53, "end": 63}]}}, "schema": []}
{"input": "This utilization of an intronic polyadenylation site without alternative exon usage is comparable to the mechanism whereby both secreted and membrane-bound forms of the immunoglobulin mu heavy chain are made from a single genetic locus.", "output": {"entities": {"gene": [{"text": "immunoglobulin mu heavy chain", "start": 169, "end": 198}]}}, "schema": []}
{"input": "To further our knowledge about the systemic humoral immune system response to weak hapten-syngeneic or allogeneic protein conjugates (corrosion and wear products of metallic orthopedic devices), a sensitive enzyme-linked immunosorbent assay (ELISA) method for testing for antibody (humoral immunity) to metals was developed.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast, peak filling rate (PFR), normalized to end diastolic volume (EDV), or stroke volume (SV), or expressed as the ratio of PFR-to-PER was reduced (p < 0. 01), time to PFR (TPFR) was prolonged (p < 0. 01), and echocardiographic left ventricular mass index was higher (p < 0. 001) in patients with acromegaly compared to normals.", "output": {"entities": {}}, "schema": []}
{"input": "A genetic complementation system was developed in which tobacco etch virus (TEV) polymerase (NIb)-expressing transgenic plants or protoplasts were inoculated with NIb-defective TEV mutants.", "output": {"entities": {"gene": [{"text": "tobacco etch virus (TEV) polymerase", "start": 56, "end": 91}, {"text": "NIb", "start": 93, "end": 96}, {"text": "NIb", "start": 163, "end": 166}, {"text": "TEV mutants", "start": 177, "end": 188}]}}, "schema": []}
{"input": "Nucleotide sequence and transcriptional analysis of the DNA polymerase gene of Bombyx mori nuclear polyhedrosis virus.", "output": {"entities": {"gene": [{"text": "DNA polymerase gene of Bombyx mori nuclear polyhedrosis virus", "start": 56, "end": 117}]}}, "schema": []}
{"input": "Comparison of the genomes of PMTV, BNYVV, and SBWMV shows that furoviruses exhibit considerable heterogeneity in genome organization.", "output": {"entities": {}}, "schema": []}
{"input": "The drug sensitivity was 100% for vancomycin (VCM), 30% for imipenam (IMP), 31% for minomycin (MINO), 31% for amikacin (AMK), and 7% for fosfomycin (FOM).", "output": {"entities": {}}, "schema": []}
{"input": "Deglycosylation with endoglycosidase H showed that the mutant receptors had mainly high-mannose oligosaccharide chains.", "output": {"entities": {"gene": [{"text": "endoglycosidase H", "start": 21, "end": 38}]}}, "schema": []}
{"input": "Dietary supplement with fish oil and related n-3 EFAs has been used to study their antihypertensive property in animals and humans with borderline and essential hypertension.", "output": {"entities": {}}, "schema": []}
{"input": "The HSD3B1 and HSD3B2 genes encoding the types I and II 3 beta-HSD isoenzymes, respectively, have been previously assigned by in situ hybridization to the chromosome 1p13. 1 region.", "output": {"entities": {"gene": [{"text": "HSD3B1", "start": 4, "end": 10}, {"text": "HSD3B2 genes", "start": 15, "end": 27}, {"text": "types I and II 3 beta-HSD isoenzymes", "start": 41, "end": 77}]}}, "schema": []}
{"input": "Therefore the prevalences of total diabetes and GDM were 1. 19% and 0. 56%, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Insulin-stimulated glucose transport in adipocytes is mediated by the insulin receptor.", "output": {"entities": {"gene": [{"text": "Insulin", "start": 0, "end": 7}, {"text": "insulin receptor", "start": 70, "end": 86}]}}, "schema": []}
{"input": "After selection and conversion to adipocytes, the level of EGFR expression was retained in infectant adipocytes (150, 000 and 250, 000/cell, respectively), but not in the parental 3T3-L1 adipocytes (< 5000/cell).", "output": {"entities": {"gene": [{"text": "EGFR", "start": 59, "end": 63}]}}, "schema": []}
{"input": "Intron-exon structure of the porcine I kappa B alpha-encoding gene.", "output": {"entities": {"gene": [{"text": "porcine I kappa B alpha-encoding gene", "start": 29, "end": 66}]}}, "schema": []}
{"input": "Fraction 2 contains 1, 25 (OH) 2-vitamin D3, vitamin D3, 25 (OH)-vitamin D3 and 1, 24, 25 (OH) 3-vitamin D3.", "output": {"entities": {}}, "schema": []}
{"input": "The kallistatin gene was localized by in situ hybridization to human chromosome 14q31-q32. 1, close to the serpin genes encoding alpha 1-antichymotrypsin, protein C inhibitor, alpha 1-antitrypsin, and corticosteroid-binding globulin.", "output": {"entities": {"gene": [{"text": "kallistatin gene", "start": 4, "end": 20}, {"text": "serpin genes", "start": 107, "end": 119}, {"text": "alpha 1-antichymotrypsin", "start": 129, "end": 153}, {"text": "protein C inhibitor", "start": 155, "end": 174}, {"text": "alpha 1-antitrypsin", "start": 176, "end": 195}, {"text": "corticosteroid-binding globulin", "start": 201, "end": 232}]}}, "schema": []}
{"input": "The locus encoding the XD gene (designated Xd) was mapped to the distal part of mouse chromosome 17 by haplotype analysis of 114 interspecific backcross mice.", "output": {"entities": {"gene": [{"text": "XD gene", "start": 23, "end": 30}, {"text": "Xd", "start": 43, "end": 45}]}}, "schema": []}
{"input": "Some studies of exercise have associated beta-endorphin release with increased exertion levels, but other evidence suggests that acidosis may stimulate the release of beta-endorphin.", "output": {"entities": {"gene": [{"text": "beta-endorphin", "start": 41, "end": 55}, {"text": "beta-endorphin", "start": 167, "end": 181}]}}, "schema": []}
{"input": "An interatrial communication mitigates the impairment of LV function after an acute and sustained drop of intrathoracic pressure.", "output": {"entities": {}}, "schema": []}
{"input": "The characteristics of the VirD1/VirD2-mediated cleavage reaction strongly resemble those observed with relaxosomes of IncP plasmids involved in initiation of transfer DNA replication during bacterial conjugation.", "output": {"entities": {"gene": [{"text": "VirD1", "start": 27, "end": 32}, {"text": "VirD2", "start": 33, "end": 38}]}}, "schema": []}
{"input": "Isoelectric focusing of tryptic peptides generated from MHC-B phosphorylated with cdc2 kinase revealed one major phosphopeptide that was purified by reverse-phase high performance liquid chromatography and sequenced.", "output": {"entities": {"gene": [{"text": "MHC-B", "start": 56, "end": 61}, {"text": "cdc2 kinase", "start": 82, "end": 93}]}}, "schema": []}
{"input": "The deduced protein sequence was 88% homologous to that of hNUC I, isolated from human osteosarcoma cells.", "output": {"entities": {"gene": [{"text": "hNUC I", "start": 59, "end": 65}]}}, "schema": []}
{"input": "A comparison of the Flavobacterium glycosylasparaginase with a mammalian glycosylasparaginase revealed 30% structural identity and 60% overall similarity between the prokaryotic and eukaryotic forms of the enzyme.", "output": {"entities": {"gene": [{"text": "glycosylasparaginase", "start": 35, "end": 55}, {"text": "glycosylasparaginase", "start": 73, "end": 93}]}}, "schema": []}
{"input": "Dissociation and complexation of the fluoroquinolone antimicrobials--an update.", "output": {"entities": {}}, "schema": []}
{"input": "Superoxide dismutase (SOD) activity decreased significantly in sperm subjected to direct electric current in comparison to the control or the sample incubated with electrolyzed medium.", "output": {"entities": {"gene": [{"text": "Superoxide dismutase", "start": 0, "end": 20}, {"text": "SOD", "start": 22, "end": 25}]}}, "schema": []}
{"input": "These studies indicate that in vitro and in vivo electrical stimulation generate reactive oxygen species and affect SOD activity, which in part are responsible for decreased sperm motion and viability.", "output": {"entities": {"gene": [{"text": "SOD", "start": 116, "end": 119}]}}, "schema": []}
{"input": "Sex selection via albumin columns: 20 years of results.", "output": {"entities": {"gene": [{"text": "albumin", "start": 18, "end": 25}]}}, "schema": []}
{"input": "They also reported that E mu pim-1 transgenic mice show greatly accelerated lymphoma development when infected with wild-type M-MuLV at birth.", "output": {"entities": {"gene": [{"text": "E mu pim-1", "start": 24, "end": 34}]}}, "schema": []}
{"input": "Comparison of human and murine blk sequences indicated that they share 86% amino acid identity, the most conserved region being the catalytic domain (93% identity).", "output": {"entities": {"gene": [{"text": "human and murine blk sequences", "start": 14, "end": 44}]}}, "schema": []}
{"input": "The effect of ethanol on human sensorimotor reactivity was assessed by examining the acoustic startle response.", "output": {"entities": {}}, "schema": []}
{"input": "Digitalis glycosides or beta-receptor antagonists are not helpful in the therapy of this form of atrial fibrillation whereas class I antiarrhythmic drugs have been shown to be more effective.", "output": {"entities": {"gene": [{"text": "beta-receptor", "start": 24, "end": 37}]}}, "schema": []}
{"input": "Atrial fibrillation and the autonomic nervous system", "output": {"entities": {}}, "schema": []}
{"input": "VIII in doses 2-3 times higher than usually used in haemophiliacs without inhibitor were successful.", "output": {"entities": {}}, "schema": []}
{"input": "A reduction of the aspartate aminotransferase activity was observed from 800 mg/kg b. w./d onwards.", "output": {"entities": {"gene": [{"text": "aspartate aminotransferase", "start": 19, "end": 45}]}}, "schema": []}
{"input": "Thus, these studies indicate that the 104-kDa isoform is required for normal proliferation of female germline cells and perhaps for oocyte differentiation.", "output": {"entities": {}}, "schema": []}
{"input": "Physical analysis maps SAL6 to chromosome XVI between TPK2 and spt14.", "output": {"entities": {"gene": [{"text": "SAL6", "start": 23, "end": 27}, {"text": "TPK2", "start": 54, "end": 58}, {"text": "spt14", "start": 63, "end": 68}]}}, "schema": []}
{"input": "The newly devised DCT method yields reliable data in measuring TBF.", "output": {"entities": {}}, "schema": []}
{"input": "Removal of PDMP from the cell medium resulted in reversal of the cell cycle changes, with cells re-entering the S phase.", "output": {"entities": {}}, "schema": []}
{"input": "Rho GDP/GTP exchange inhibitor, Rho GDI, comigrated with Rac2 and RhoA, but not Rac1.", "output": {"entities": {"gene": [{"text": "Rho GDP/GTP exchange inhibitor", "start": 0, "end": 30}, {"text": "Rho GDI", "start": 32, "end": 39}, {"text": "Rac2", "start": 57, "end": 61}, {"text": "RhoA", "start": 66, "end": 70}, {"text": "Rac1", "start": 80, "end": 84}]}}, "schema": []}
{"input": "Schnell, J.", "output": {"entities": {}}, "schema": []}
{"input": "Encapsidation of poliovirus replicons encoding the complete human immunodeficiency virus type 1 gag gene by using a complementation system which provides the P1 capsid protein in trans.", "output": {"entities": {"gene": [{"text": "human immunodeficiency virus type 1 gag gene", "start": 60, "end": 104}, {"text": "P1 capsid protein", "start": 158, "end": 175}]}}, "schema": []}
{"input": "The requirement of PilE in pilus biogenesis was confirmed by demonstrating that chromosomal pilE insertion mutants were pilus-and twitching-motility deficient.", "output": {"entities": {"gene": [{"text": "PilE", "start": 19, "end": 23}, {"text": "chromosomal pilE insertion mutants", "start": 80, "end": 114}]}}, "schema": []}
{"input": "The pilE gene product of Pseudomonas aeruginosa, required for pilus biogenesis, shares amino acid sequence identity with the N-termini of type 4 prepilin proteins.", "output": {"entities": {"gene": [{"text": "pilE gene product of Pseudomonas aeruginosa", "start": 4, "end": 47}, {"text": "type 4 prepilin proteins", "start": 138, "end": 162}]}}, "schema": []}
{"input": "Because of the functional conservation of cell cycle control elements, the expression of a vertebrate wee1 or mik1 homolog would be expected to rescue such lethal mutations in yeast.", "output": {"entities": {"gene": [{"text": "vertebrate wee1", "start": 91, "end": 106}, {"text": "mik1 homolog", "start": 110, "end": 122}]}}, "schema": []}
{"input": "The expression of this clone in a wee1/mik1-deficient mutant causes an elongated cell phenotype under non-permissive growth conditions.", "output": {"entities": {"gene": [{"text": "wee1", "start": 34, "end": 38}, {"text": "mik1", "start": 39, "end": 43}]}}, "schema": []}
{"input": "These data indicate that phosphorylation of M protein at the major in vivo sites is not essential for virus assembly.", "output": {"entities": {"gene": [{"text": "M protein", "start": 44, "end": 53}]}}, "schema": []}
{"input": "Near a third (31. 6%) of Insulin Dependent and a third (33. 41%) for Non Insulin Dependent were of D, F, H White' s Class.", "output": {"entities": {"gene": [{"text": "Insulin", "start": 25, "end": 32}, {"text": "Insulin", "start": 73, "end": 80}]}}, "schema": []}
{"input": "The activity of 6-fluoroquinolones and their nonfluorinated derivatives is compared in general.", "output": {"entities": {}}, "schema": []}
{"input": "As the half-life of the compound did never exceed 8-9 h, the data do not support any change of pidotimod administration schedule (every 24-12 h).", "output": {"entities": {}}, "schema": []}
{"input": "The MAP kinase cascade is highly conserved in all eukaryotes and involved in numerous cellular responses.", "output": {"entities": {"gene": [{"text": "MAP kinase", "start": 4, "end": 14}]}}, "schema": []}
{"input": "A comparative study by holographic interferometry of ten porcine bioprosthetic valves (seven Carpentier-Edwards SAV, two BioImplant and one Valcor) with five human aortic valves before and after glutaraldehyde treatment is presented.", "output": {"entities": {}}, "schema": []}
{"input": "No serious side effects were observed.", "output": {"entities": {}}, "schema": []}
{"input": "This region constitutes the DNA-binding domain with basic-helix-loop-helix and leucine-zipper motifs, features common to the myc-related transcription factor family.", "output": {"entities": {"gene": [{"text": "myc-related transcription factor family", "start": 125, "end": 164}]}}, "schema": []}
{"input": "The mean jitter and the fiber density did not change significantly from day 0 (30. 1 +/-3. 6 microseconds; 1. 4 +/-0. 07) to day 30 (34. 5 +/-2. 7 microseconds; 1. 6 +/-0. 13).", "output": {"entities": {}}, "schema": []}
{"input": "Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product.", "output": {"entities": {"gene": [{"text": "cyclin D", "start": 8, "end": 16}, {"text": "Cdk", "start": 17, "end": 20}, {"text": "Rb", "start": 34, "end": 36}, {"text": "p16INK4", "start": 83, "end": 90}, {"text": "MTS1", "start": 91, "end": 95}]}}, "schema": []}
{"input": "Recombinant human serum albumin (rHSA) produced by cultured fermentation has been prepared in the form of microcapsules nominally 3-5 microns in diameter and radiolabelled with technetium-99m following reduction with stannous chloride.", "output": {"entities": {"gene": [{"text": "Recombinant human serum albumin", "start": 0, "end": 31}, {"text": "rHSA", "start": 33, "end": 37}]}}, "schema": []}
{"input": "We have measured the release of interleukin-1 beta (IL-1) and tumour necrosis factor-alpha (TNF) by unstimulated monocytes and monocytes stimulated with lipopolysaccharide (LPS) isolated from the peripheral blood of two patients with acute poststreptococcal glomerulonephritis (AGN) and 16 healthy controls.", "output": {"entities": {"gene": [{"text": "interleukin-1 beta", "start": 32, "end": 50}, {"text": "IL-1", "start": 52, "end": 56}, {"text": "tumour necrosis factor-alpha", "start": 62, "end": 90}, {"text": "TNF", "start": 92, "end": 95}]}}, "schema": []}
{"input": "Such an intervention may be of considerable use for the treatment of angiogenesis-dependent diseases involving FGF-2.", "output": {"entities": {"gene": [{"text": "FGF-2", "start": 111, "end": 116}]}}, "schema": []}
{"input": "UV cross-linking experiments show that TEP has an apparent molecular mass of approximately 65 kDa.", "output": {"entities": {"gene": [{"text": "TEP", "start": 39, "end": 42}]}}, "schema": []}
{"input": "Alternatively, loss-of-function alleles of genes that inhibit cAPK lead to the inability to undergo sexual differentiation.", "output": {"entities": {"gene": [{"text": "cAPK", "start": 62, "end": 66}]}}, "schema": []}
{"input": "One member of this family, RFX1, is a transcription factor for a variety of viral and cellular genes.", "output": {"entities": {"gene": [{"text": "RFX1", "start": 27, "end": 31}]}}, "schema": []}
{"input": "This mutant was identified by screening with a TGF-beta-inducible vector a series of mink lung epithelial cell clones that have normal TGF-beta binding activity but have lost antiproliferative and transcriptional responses to TGF-beta.", "output": {"entities": {"gene": [{"text": "TGF-beta", "start": 47, "end": 55}, {"text": "TGF-beta", "start": 135, "end": 143}, {"text": "TGF-beta", "start": 226, "end": 234}]}}, "schema": []}
{"input": "Cloning by complementation and subsequent physical and genetic analysis revealed that it maps to RAF1.", "output": {"entities": {"gene": [{"text": "RAF1", "start": 97, "end": 101}]}}, "schema": []}
{"input": "In the presence of inositol and choline (repressing), the product of the OPI1 gene represses transcription dictated by the UASINO element.", "output": {"entities": {"gene": [{"text": "OPI1 gene", "start": 73, "end": 82}]}}, "schema": []}
{"input": "By treating monkey COS cells with oligonucleotides linked to psoralen, we have generated targeted mutations in a simian virus 40 (SV40) vector contained within the cells via intracellular triple helix formation.", "output": {"entities": {}}, "schema": []}
{"input": "The interleukin 2 receptor alpha-chain (IL-2R alpha) gene is rapidly and potently induced in T cells in response to mitogenic stimuli.", "output": {"entities": {"gene": [{"text": "interleukin 2 receptor alpha-chain", "start": 4, "end": 38}, {"text": "IL-2R alpha", "start": 40, "end": 51}]}}, "schema": []}
{"input": "The Wilms' tumour suppressor protein (WT1) is a putative transcriptional regulatory protein with four zinc fingers, the last three of which have extensive sequence homology to the early growth response-1 (EGR-1) protein.", "output": {"entities": {"gene": [{"text": "Wilms' tumour suppressor protein", "start": 4, "end": 36}, {"text": "WT1", "start": 38, "end": 41}, {"text": "early growth response-1", "start": 180, "end": 203}, {"text": "EGR-1", "start": 205, "end": 210}]}}, "schema": []}
{"input": "OBJECTIVES: 1) to determine serum ACE activity in patients with COPD treated with and without continuous ambulatory oxygen therapy (CAOT); 2) to verify whether there is a correlation between ACE and any hematological, spirometric or gasometric parameter.", "output": {"entities": {"gene": [{"text": "serum ACE", "start": 28, "end": 37}, {"text": "ACE", "start": 191, "end": 194}]}}, "schema": []}
{"input": "In order to infer shape from contour, the human visual system must selectively integrate fragments projecting from a common object while keeping fragments from different objects separate.", "output": {"entities": {}}, "schema": []}
{"input": "Among 9 group I patients with a positive result on head-up tilt-table testing and no evidence of structural heart disease (mean follow-up 4. 3 years), 7 are without further episodes of syncope; 3 have discontinued medication and 5 have resumed at least limited exercise.", "output": {"entities": {}}, "schema": []}
{"input": "Constructs designed and expressed were E2L1 (1-98), E2L1. H1 (1-128), E2L2 (120-233), E2H1. L2 (98-233), and E2L1. H1. L2 (1-233), where numbers in parentheses give the amino acid sequence for the portions of the E2 component incorporated into a construct.", "output": {"entities": {"gene": [{"text": "E2L1 (1-98)", "start": 39, "end": 50}, {"text": "E2L1. H1 (1-128)", "start": 52, "end": 68}, {"text": "E2L2 (120-233)", "start": 70, "end": 84}, {"text": "E2H1. L2 (98-233)", "start": 86, "end": 103}, {"text": "E2L1. H1. L2 (1-233)", "start": 109, "end": 129}, {"text": "E2", "start": 213, "end": 215}]}}, "schema": []}
{"input": "Thus, we have produced lipoyl domain constructs that can be employed in sorting the specific roles of E2L1 and E2L2 in facilitating catalytic and regulatory processes.", "output": {"entities": {"gene": [{"text": "E2L1", "start": 102, "end": 106}, {"text": "E2L2", "start": 111, "end": 115}]}}, "schema": []}
{"input": "METHODS: Ten influenza A (H3N2) viruses isolated during the outbreaks were examined for resistance to amantadine and rimantadine by means of an enzyme immunoassay and by sequencing of the viral nucleic acid that encodes the transmembrane domain of the M2 protein.", "output": {"entities": {"gene": [{"text": "M2 protein", "start": 252, "end": 262}]}}, "schema": []}
{"input": "The first contains ATF/CRE and TBP/TATA sequence motifs within an 87-bp region.", "output": {"entities": {"gene": [{"text": "ATF", "start": 19, "end": 22}, {"text": "TBP", "start": 31, "end": 34}]}}, "schema": []}
{"input": "Gene expression occurs in a circadian rhythm and induced by light in leaves of dark-adapted plants.", "output": {"entities": {}}, "schema": []}
{"input": "Our results suggested that the hexamer and the octamer motifs may play important role (s) in regulation of replication-dependent but not of replication-independent expression of the wheat histone H3 gene.", "output": {"entities": {"gene": [{"text": "wheat histone H3 gene", "start": 182, "end": 203}]}}, "schema": []}
{"input": "The tissue-specific expression of DP family members suggests that the combination of DP/E2F heterodimers that constitute DRTF1/E2F is influenced by the phenotype of the cell.", "output": {"entities": {"gene": [{"text": "DP family members", "start": 34, "end": 51}, {"text": "DP", "start": 85, "end": 87}, {"text": "E2F", "start": 88, "end": 91}, {"text": "DRTF1", "start": 121, "end": 126}, {"text": "E2F", "start": 127, "end": 130}]}}, "schema": []}
{"input": "In a second experiment involving an 18-h lung clearance assay, we used the mAb 3. 2. 3 to deplete rats of LGL/NK cells with the following rationale: if LGL/NK cells are necessary to mediate an event, then in their absence, that event should not occur.", "output": {"entities": {"gene": [{"text": "mAb 3. 2. 3", "start": 75, "end": 86}]}}, "schema": []}
{"input": "Treatment of recurrent FSGS has included high-dose steroids, high-dose cyclosporine (CSA), plasmapheresis, and ACE inhibitors with mixed results.", "output": {"entities": {"gene": [{"text": "ACE", "start": 111, "end": 114}]}}, "schema": []}
{"input": "Our results concluded that 1) the two inhibin/activin beta B-subunit mRNAs were transcribed from different initiation sites; 2) both promoters may be controlled by up-stream negative regulatory elements; and 3) neither of these promoters is responsive to cAMP and/or phorbol esters under the conditions employed.", "output": {"entities": {"gene": [{"text": "inhibin", "start": 38, "end": 45}, {"text": "activin", "start": 46, "end": 53}]}}, "schema": []}
{"input": "Promoter region of the transcriptional unit for human alpha 1-chimaerin, a neuron-specific GTPase-activating protein for p21rac. alpha 1-chimaerin is a neuron-specific GTPase-activating protein for p21rac, a protein involved in morphological events.", "output": {"entities": {"gene": [{"text": "human alpha 1-chimaerin", "start": 48, "end": 71}, {"text": "neuron-specific GTPase-activating protein", "start": 75, "end": 116}, {"text": "p21rac", "start": 121, "end": 127}, {"text": "alpha 1-chimaerin", "start": 129, "end": 146}, {"text": "neuron-specific GTPase-activating protein", "start": 152, "end": 193}, {"text": "p21rac", "start": 198, "end": 204}]}}, "schema": []}
{"input": "Upstream from the transcription start point (tsp), a nucleotide sequence highly homologous to the consensus sequence motif for the sigma 35-recognized promoters was found.", "output": {"entities": {"gene": [{"text": "consensus sequence motif for the sigma 35-recognized promoters", "start": 98, "end": 160}]}}, "schema": []}
{"input": "In this paper, an analysis of the dynamics in the closing phase of the occluder of a mechanical monoleaflet heart valve prosthesis is presented.", "output": {"entities": {}}, "schema": []}
{"input": "During ISO + AT infusion, abdominal fat blood flow was still significantly increased as compared with control values in lean and obese subjects.", "output": {"entities": {}}, "schema": []}
{"input": "When expressed per kilogram body weight, mean GIT increased in the dF group from 0. 14% to 0. 16% above RMR, with a significant decrease from 0. 15% to 0. 13% in the P group.", "output": {"entities": {}}, "schema": []}
{"input": "In nucleus ventralis anterior thalami-nucleus ventralis lateralis thalami neurons with an inhibitory input from nucleus entopeduncularis, a shortening of inhibition from 17. 5 +/-3. 6 to 9. 1 +/-1. 8 ms (P < 0. 05) under the haloperidol influence was evident.", "output": {"entities": {}}, "schema": []}
{"input": "However, inclusion of the neighboring CGGAAR motifs from the ICP4 promoter, which bind factors GABP alpha and beta, results in a strong synergistic activation.", "output": {"entities": {"gene": [{"text": "ICP4 promoter", "start": 61, "end": 74}, {"text": "GABP alpha and beta", "start": 95, "end": 114}]}}, "schema": []}
{"input": "This finding represents both a potentially important mechanism by which HPV gene expression can be regulated and an interesting model for the study of transcriptional cooperativity.", "output": {"entities": {}}, "schema": []}
{"input": "Using this method, VLPs were obtained in quantities sufficient for further characterization.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of the sequence upstream of this initiation codon reveals the presence of a promotor sequence.", "output": {"entities": {}}, "schema": []}
{"input": "SUP46 is implicated in translation fidelity and encodes the ribosomal protein S13.", "output": {"entities": {"gene": [{"text": "SUP46", "start": 0, "end": 5}, {"text": "ribosomal protein S13", "start": 60, "end": 81}]}}, "schema": []}
{"input": "To explore the functional relationship between c-fos and Rb, a eukaryotic expression plasmid was constructed containing the c-fos gene under control of the SV40 promoter complex.", "output": {"entities": {"gene": [{"text": "c-fos", "start": 47, "end": 52}, {"text": "Rb", "start": 57, "end": 59}, {"text": "c-fos gene", "start": 124, "end": 134}, {"text": "SV40 promoter", "start": 156, "end": 169}]}}, "schema": []}
{"input": "The high degree of sequence identity (96%) between hydrolase B and C, particularly in the 3' untranslated region, suggests that the genes encoding these two carboxylesterases evolved by duplication and divergence of a common ancestral gene.", "output": {"entities": {"gene": [{"text": "hydrolase B and C", "start": 51, "end": 68}, {"text": "carboxylesterases", "start": 157, "end": 174}]}}, "schema": []}
{"input": "The regions of the tooth fracture are determined.", "output": {"entities": {}}, "schema": []}
{"input": "Secondary pancreatic involvement of mycosis fungoides detected by a clinically palpable mass.", "output": {"entities": {}}, "schema": []}
{"input": "The NR2 hybrid is a powerful tool for the mapping of new probes of this region, as well as for obtaining new informative probes specific for the deletion by subtractive cloning of the region.", "output": {"entities": {}}, "schema": []}
{"input": "TDEYA at doses of 200 to 500 mg/kg significantly suppressed xanthine oxidase (XO) activity in the stomach tissue following its oral administration.", "output": {"entities": {"gene": [{"text": "xanthine oxidase", "start": 60, "end": 76}, {"text": "XO", "start": 78, "end": 80}]}}, "schema": []}
{"input": "Like humans, the PITSLRE PK genes in chickens must be closely linked, based on fluorescent in situ hybridization (FISH) localization of these genes to a single chicken microchromosome.", "output": {"entities": {"gene": [{"text": "PITSLRE PK genes in chickens", "start": 17, "end": 45}]}}, "schema": []}
{"input": "Here, we report the characterization of an alternatively processed form of AFAP-110 that encodes an additional 258 base pair (bp) of open reading frame.", "output": {"entities": {"gene": [{"text": "AFAP-110", "start": 75, "end": 83}]}}, "schema": []}
{"input": "Expression of class IV ADH mRNA was detected in human stomach but not liver.", "output": {"entities": {"gene": [{"text": "class IV ADH mRNA", "start": 14, "end": 31}]}}, "schema": []}
{"input": "In ICE gamma, most of the propeptide (amino acids 20-112) is deleted, which suggests that it may function as a catalyst for ICE autoprocessing in vivo.", "output": {"entities": {"gene": [{"text": "ICE gamma", "start": 3, "end": 12}, {"text": "ICE", "start": 124, "end": 127}]}}, "schema": []}
{"input": "Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain.", "output": {"entities": {"gene": [{"text": "epidermal growth factor receptors", "start": 39, "end": 72}, {"text": "tyrosine kinase domain", "start": 127, "end": 149}]}}, "schema": []}
{"input": "It is now recognized that essentially all eukaryotic and prokaryotic genes whose 5'-flanking regions are known and that encode barbiturate-inducible proteins contain the Barbie box element.", "output": {"entities": {}}, "schema": []}
{"input": "Mutation of the P450BM-3 Barbie box significantly increased the expression of both P450BM-3 and Bm3P1 (another small gene located upstream of the P450BM-3 gene that encodes a second putative regulatory protein) in response to pentobarbital induction but left the basal levels unaffected.", "output": {"entities": {"gene": [{"text": "P450BM-3 Barbie box", "start": 16, "end": 35}, {"text": "P450BM-3", "start": 83, "end": 91}, {"text": "Bm3P1", "start": 96, "end": 101}, {"text": "P450BM-3 gene", "start": 146, "end": 159}]}}, "schema": []}
{"input": "A potential outcome of these biochemical effects may include the limited responsiveness of infected T cells to antigenic stimulation observed during HIV-1 infection.", "output": {"entities": {}}, "schema": []}
{"input": "The full protocol was completed by 33 patients (45% of original cohort).", "output": {"entities": {}}, "schema": []}
{"input": "In addition, we found that cell-specific suppression of RA-stimulated zif268 gene expression can be attributed to a 29 base pair nucleotide sequence, located downstream of the RA-responsive region in the zif268 gene.", "output": {"entities": {"gene": [{"text": "zif268 gene", "start": 70, "end": 81}, {"text": "zif268 gene", "start": 204, "end": 215}]}}, "schema": []}
{"input": "We show that CBF-A and CBF-C interact with each other to form a CBF-A-CBF-C complex and that CBF-B does not interact with CBF-A or CBF-C individually but that it associates with the CBF-A-CBF-C complex.", "output": {"entities": {"gene": [{"text": "CBF-A", "start": 13, "end": 18}, {"text": "CBF-C", "start": 23, "end": 28}, {"text": "CBF-A", "start": 64, "end": 69}, {"text": "CBF-C", "start": 70, "end": 75}, {"text": "CBF-B", "start": 93, "end": 98}, {"text": "CBF-A", "start": 122, "end": 127}, {"text": "CBF-C", "start": 131, "end": 136}, {"text": "CBF-A", "start": 182, "end": 187}, {"text": "CBF-C", "start": 188, "end": 193}]}}, "schema": []}
{"input": "In the first, homologous sequences were deleted from a mouse enhancer, resulting in a tissue-specific loss of activity when assayed in transgenic mice.", "output": {"entities": {}}, "schema": []}
{"input": "OKT3 prophylaxis improves long-term renal graft survival in high-risk patients as compared to cyclosporine: combined results from the prospective, randomized Belgian and US studies.", "output": {"entities": {"gene": [{"text": "OKT3", "start": 0, "end": 4}]}}, "schema": []}
{"input": "The major PKC beta transcription initiation site was identified by primer extension and S1 nuclease protection.", "output": {"entities": {"gene": [{"text": "PKC beta", "start": 10, "end": 18}, {"text": "S1 nuclease", "start": 88, "end": 99}]}}, "schema": []}
{"input": "In the course of a study of low dose X-rays effects, we found that male ICR white Swiss mice showed remarkable suppression of mounting behavior after whole body irradiation by 5 to 15 cGy X-rays.", "output": {"entities": {}}, "schema": []}
{"input": "A quantitative analysis of the diffraction intensity as function of the accumulated electron dose suggests the possibility of recording up to 250 diffraction patterns with 3. 5 A resolution from a single crotoxin complex crystal 128 A thick.", "output": {"entities": {}}, "schema": []}
{"input": "Supplementary Phase Contraste RSE (\" Rapid Sequential Excitation \") sequences were carried out in 29 patients.", "output": {"entities": {}}, "schema": []}
{"input": "In yeast, the products of the UPF1 and UPF3 genes are required for this decay pathway, and in this report we focus on the identification and characterization of additional factors required for rapid decay of nonsense-containing mRNAs.", "output": {"entities": {"gene": [{"text": "UPF1", "start": 30, "end": 34}, {"text": "UPF3 genes", "start": 39, "end": 49}]}}, "schema": []}
{"input": "Mutations in UPF1 lead to the selective stabilization of mRNAs containing early nonsense mutations without affecting the decay rates of most other mRNAs.", "output": {"entities": {"gene": [{"text": "UPF1", "start": 13, "end": 17}]}}, "schema": []}
{"input": "A DNA fragment encoding the DNA-binding domain (amino acids 1-60) of the Escherichia coli fru transcriptional regulator was cloned into the pGEX-KT vector and expressed in frame with the fused gene encoding glutathione S-transferase.", "output": {"entities": {"gene": [{"text": "Escherichia coli fru transcriptional regulator", "start": 73, "end": 119}, {"text": "glutathione S-transferase", "start": 207, "end": 232}]}}, "schema": []}
{"input": "0. 61 +/-0. 04).", "output": {"entities": {}}, "schema": []}
{"input": "Several nuclear factors that interact with sequences in the 5' flanking region of the mouse tyrosinase gene were identified using band shift and methylation interference assays.", "output": {"entities": {"gene": [{"text": "mouse tyrosinase gene", "start": 86, "end": 107}]}}, "schema": []}
{"input": "With a population of 853 million there should be 51, 204 patients with hemophilia A in India assuming a prevalence of 6/100, 000 population.", "output": {"entities": {}}, "schema": []}
{"input": "When combined with serum ferritin and hemoglobin determinations, the serum transferrin receptor assay is a valuable addition in epidemiologic surveys because it provides a quantitative measure of functional iron deficiency and it distinguishes true IDA from the anemia of chronic disease.", "output": {"entities": {"gene": [{"text": "ferritin", "start": 25, "end": 33}, {"text": "hemoglobin", "start": 38, "end": 48}, {"text": "transferrin receptor", "start": 75, "end": 95}]}}, "schema": []}
{"input": "Since 1990 the University Hospital of Tromso has provided local hospitals in northern Norway with a remote frozen section service and with access to video conferences for the review of microscopic findings and for the discussion of major diagnostic issues.", "output": {"entities": {}}, "schema": []}
{"input": "Current status of telepathology.", "output": {"entities": {}}, "schema": []}
{"input": "PMEK1 displays 96 and 80% identity respectively with the tobacco NTF3 and Arabidopsis ATMPK1 kinases, and only 50% to the more distantly related plant MAP kinase MsERK1 from alfalfa.", "output": {"entities": {"gene": [{"text": "PMEK1", "start": 0, "end": 5}, {"text": "tobacco NTF3", "start": 57, "end": 69}, {"text": "Arabidopsis ATMPK1 kinases", "start": 74, "end": 100}, {"text": "MsERK1", "start": 162, "end": 168}]}}, "schema": []}
{"input": "Translation of the coding segment, which was designated MsPRP2, suggested it encodes a chimeric 40, 569 Da cell wall protein with an amino-terminal signal sequence, a repetitive proline-rich sequence, and a cysteine-rich carboxyl-terminal sequence homologous to nonspecific lipid transfer proteins.", "output": {"entities": {"gene": [{"text": "MsPRP2", "start": 56, "end": 62}]}}, "schema": []}
{"input": "The presence of type I hypersensitivity in a subgroup of aspergillomas suggests an immunoallergic component to this disease which could contribute to a chronic inflammatory response to Aspergillus in some aspergillomas.", "output": {"entities": {}}, "schema": []}
{"input": "This concept is supported by the identification of RH-like genes in non human primates.", "output": {"entities": {"gene": [{"text": "RH-like genes", "start": 51, "end": 64}]}}, "schema": []}
{"input": "With steady illumination, outer retinal (photoreceptor) QO2 decreased to 1. 4 +/-0. 9 ml O2/(100 g. min), but inner retinal QO2 remained unchanged at 3. 7 +/-1. 5 ml O2/(100 g. min) (5 cats).", "output": {"entities": {}}, "schema": []}
{"input": "We have screened the mouse cDNA library of an MIN6 cell line, derived from pancreatic beta cells, for its novel isoform and have identified a cDNA encoding a 593-amino acid protein having 63, 53, and 30% identity with munc-18/n-Sec1/rbSec1, Caenorhabditis elegans unc18, and Saccharomyces cerevisiae Sec1p, respectively.", "output": {"entities": {"gene": [{"text": "munc-18/n-Sec1/rbSec1", "start": 218, "end": 239}, {"text": "Caenorhabditis elegans unc18", "start": 241, "end": 269}, {"text": "Saccharomyces cerevisiae Sec1p", "start": 275, "end": 305}]}}, "schema": []}
{"input": "The catenins bind to APC and E-cadherin in a similar fashion, but APC and E-cadherin do not associate with each other either in the presence or absence of catenins.", "output": {"entities": {"gene": [{"text": "catenins", "start": 4, "end": 12}, {"text": "APC", "start": 21, "end": 24}, {"text": "E-cadherin", "start": 29, "end": 39}, {"text": "APC", "start": 66, "end": 69}, {"text": "E-cadherin", "start": 74, "end": 84}, {"text": "catenins", "start": 155, "end": 163}]}}, "schema": []}
{"input": "However, addition of core DNA polymerase III to preinitiation complex, fully reconstituting holoenzyme resulted in replacement of gamma by alpha at the primer terminus.", "output": {"entities": {"gene": [{"text": "core DNA polymerase III", "start": 21, "end": 44}]}}, "schema": []}
{"input": "Computerized detection of abnormal asymmetry in digital chest radiographs.", "output": {"entities": {}}, "schema": []}
{"input": "These results suggest that gluconeogenic genes are derepressed upon binding of Cat8p, whose synthesis depends on the release of Cat4p (Mig1p) from the CAT8 promoter.", "output": {"entities": {"gene": [{"text": "Cat8p", "start": 79, "end": 84}, {"text": "Cat4p", "start": 128, "end": 133}, {"text": "Mig1p", "start": 135, "end": 140}, {"text": "CAT8 promoter", "start": 151, "end": 164}]}}, "schema": []}
{"input": "We show here that the binding of C1F in vitro is sensitive to the concentration of calcium ions.", "output": {"entities": {"gene": [{"text": "C1F", "start": 33, "end": 36}]}}, "schema": []}
{"input": "Survival after development of symptomatic infection (P-2) did not differ by transmission mode.", "output": {"entities": {}}, "schema": []}
{"input": "These data suggest that the function of the DS2 may be the protection of the nuclear DNA from desiccation.", "output": {"entities": {"gene": [{"text": "DS2", "start": 44, "end": 47}]}}, "schema": []}
{"input": "Glomerular hemodynamics during abortion induced by RU 486 and sepsis in rats.", "output": {"entities": {}}, "schema": []}
{"input": "The aim of this retrospective study was to demonstrate that in certain cases of expulsive choroidal hemorrhage (ECH) anatomical success and useful vision can be obtained with repeated vitreoretinal surgery.", "output": {"entities": {}}, "schema": []}
{"input": "The function of the C-terminal tail in telomere maintenance is not mediated through the RAP1 interacting factor RIF1: rap1 alleles defective in both the C-terminal tail and RIF1 interaction domains have additive effects on telomere length.", "output": {"entities": {"gene": [{"text": "RAP1 interacting factor RIF1", "start": 88, "end": 116}, {"text": "rap1 alleles", "start": 118, "end": 130}, {"text": "RIF1 interaction domains", "start": 173, "end": 197}]}}, "schema": []}
{"input": "The contribution of skin flow to the changes in 760-800 nm absorption was investigated by simultaneous measurement of skin flow by laser flow Doppler and NIR recordings during hot water immersion.", "output": {"entities": {}}, "schema": []}
{"input": "Proteins immunoprecipitated from lysates of control-and VEGF-stimulated BAEC with antisera to phospholipase C-gamma (PLC-gamma) were fractionated by SDS-polyacrylamide gel electrophoresis and transferred to Immobilon-P.", "output": {"entities": {"gene": [{"text": "VEGF", "start": 56, "end": 60}, {"text": "phospholipase C-gamma", "start": 94, "end": 115}, {"text": "PLC-gamma", "start": 117, "end": 126}]}}, "schema": []}
{"input": "Alternatively processed isoforms of cellular nucleic acid-binding protein interact with a suppressor region of the human beta-myosin heavy chain gene.", "output": {"entities": {"gene": [{"text": "cellular nucleic acid-binding protein", "start": 36, "end": 73}, {"text": "human beta-myosin heavy chain gene", "start": 115, "end": 149}]}}, "schema": []}
{"input": "Involvement of early growth response factor Egr-1 in apolipoprotein AI gene transcription.", "output": {"entities": {"gene": [{"text": "early growth response factor Egr-1", "start": 15, "end": 49}, {"text": "apolipoprotein AI gene", "start": 53, "end": 75}]}}, "schema": []}
{"input": "The wild-type and altered forms of the F protein were expressed in BHK-21 and HeLa T4 cells by use of the recombinant vaccinia virus-encoding T7 polymerase system.", "output": {"entities": {"gene": [{"text": "F protein", "start": 39, "end": 48}, {"text": "recombinant vaccinia virus-encoding T7 polymerase", "start": 106, "end": 155}]}}, "schema": []}
{"input": "Erythrocyte delta-aminolevulinic acid dehydratase (ALAD) activity, erythrocyte zinc protoporphyrin (ZPP)/heme ratio, and urinary coproporphyrin (UC) concentration have been employed as biological indicators of moderate-to high-level lead exposure, corresponding to blood levels in excess of 50 micrograms/dl, in human subjects.", "output": {"entities": {"gene": [{"text": "Erythrocyte delta-aminolevulinic acid dehydratase", "start": 0, "end": 49}, {"text": "ALAD", "start": 51, "end": 55}]}}, "schema": []}
{"input": "The relative risk of graft loss after conversion to azathioprine compared with graft loss after conversion to azathioprine compared with cyclosporin maintenance was 0. 71 (0. 37-1. 38) and the relative risk of patient death was 0. 57 (0. 23-1. 41).", "output": {"entities": {}}, "schema": []}
{"input": "The \" tobacco issue \".", "output": {"entities": {}}, "schema": []}
{"input": "The effect of the Ca entry blocker nitrendipine, the antioxidant superoxide dismutase (SOD), and a combination of nitrendipine and superoxide dismutase on postischemic renal function was studied in four groups (n = 24) of rats.", "output": {"entities": {"gene": [{"text": "superoxide dismutase", "start": 65, "end": 85}, {"text": "SOD", "start": 87, "end": 90}, {"text": "superoxide dismutase", "start": 131, "end": 151}]}}, "schema": []}
{"input": "PURPOSE: The aim of this study was to evaluate the bony anchorage of a new implant (orderly wired surface effect with alloy Ti Al Va and ordered pores of 488 mu).", "output": {"entities": {}}, "schema": []}
{"input": "To determine whether food and/or water in the gastrointestinal tract affects restitution of blood volume and plasma protein after hemorrhage, fed and 24-h-fasted awake rats received a 20 ml. kg-1 x 3 min-1 hemorrhage, and restitution of blood volume was measured by Evans blue dye and dilution of hematocrit.", "output": {"entities": {}}, "schema": []}
{"input": "Cooperative dimerization of paired class homeo domains on DNA.", "output": {"entities": {"gene": [{"text": "paired", "start": 28, "end": 34}]}}, "schema": []}
{"input": "We took advantage of the high degree of aa sequence homology between DAHPSs from several species to isolate ARO3 homologues from the pathogenic yeast Candida albicans.", "output": {"entities": {"gene": [{"text": "DAHPSs", "start": 69, "end": 75}, {"text": "ARO3 homologues", "start": 108, "end": 123}]}}, "schema": []}
{"input": "In this study, we demonstrate that BOX DNA enhances transcription from the thymidine kinase (TK) promoter in various EC cells.", "output": {"entities": {"gene": [{"text": "thymidine kinase", "start": 75, "end": 91}, {"text": "TK", "start": 93, "end": 95}]}}, "schema": []}
{"input": "Deletion analyses of the construct revealed that the transcription of BOXF1 gene is regulated by BOX DNA, preferentially in undifferentiated EC cells versus differentiated cells.", "output": {"entities": {"gene": [{"text": "BOXF1 gene", "start": 70, "end": 80}]}}, "schema": []}
{"input": "The presence of an unusual transcript possessing IVS2C beta 1 at the 5' terminus suggests that cleavage of its splice acceptor is inefficient or negatively regulated.", "output": {"entities": {"gene": [{"text": "IVS2C beta 1", "start": 49, "end": 61}]}}, "schema": []}
{"input": "During chronic treatment, when plasma concentrations fluctuated between 23. 5 ng. ml-1 at 8 h and 14 ng. ml-1 at 24 h post-dosing, ST segment depression at an individually comparable workload was significantly decreased by 28% compared with placebo (P < 0. 005) at both points in time.", "output": {"entities": {}}, "schema": []}
{"input": "Results from in vitro transcription-translation analysis and maxicell experiments suggested that the 447-bp ORF was the one being actively expressed.", "output": {"entities": {}}, "schema": []}
{"input": "Preliminary experiments demonstrated that it was possible to produce fasD mutants, whose products remain functional for fimbrial export and assembly.", "output": {"entities": {"gene": [{"text": "fasD mutants", "start": 69, "end": 81}]}}, "schema": []}
{"input": "Evoked electromyographic response to indirect supramaximal stimulation at 1 Hz was monitored in ten adult goats under thiopentone-halothane anaesthesia.", "output": {"entities": {}}, "schema": []}
{"input": "313, 98-102).", "output": {"entities": {}}, "schema": []}
{"input": "Group 6 was given physostigmine, 0. 1 mg/kg i. v., known to inhibit cholinesterase degradation, 5 min before bupivacaine administration, and Group 7 received a combination of physostigmine pretreatment and electrical vagal stimulation.", "output": {"entities": {"gene": [{"text": "cholinesterase", "start": 68, "end": 82}]}}, "schema": []}
{"input": "To examine the possibility that LNNB performance of the schizophrenic groups may have been related to neuroleptic medication, analyses were completed on the relationship between medication levels and LNNB scores.", "output": {"entities": {}}, "schema": []}
{"input": "ISIS 5 possibilities.", "output": {"entities": {}}, "schema": []}
{"input": "The use of specific antibodies allowed the identification of at least RAR beta in some of the DNA-protein complexes, although the four sequences bind single RARs transfected in COS cells much less efficiently, or not at all, when compared to a canonical RAR responsive element.", "output": {"entities": {"gene": [{"text": "RAR beta", "start": 70, "end": 78}, {"text": "RARs", "start": 157, "end": 161}, {"text": "RAR responsive element", "start": 254, "end": 276}]}}, "schema": []}
{"input": "The present treatment strategy in progressive disorders is mainly based on the complementary effect of intensive radiochemotherapy, autologous stem-cell transplantation and the rational use of cytokines, mostly colony-stimulating factors.", "output": {"entities": {"gene": [{"text": "colony-stimulating factors", "start": 211, "end": 237}]}}, "schema": []}
{"input": "Our study cohorts consisted of 15 patients who received SC rIL-2 at doses of 4. 8-14. 4 million IU/m2/day on 5 days per week for a total of 8 weeks, 20 patients who received rIFN-alpha 2b at 3. 0-6. 0 million U/m2/day thrice weekly for a total of 6 weeks, and 72 patients who were given SC rIFN-alpha 2b at 6. 0 million U/m2/day thrice weekly plus SC rIL-2 at 14. 4-18. 0 million IU/m2/day on days 1 and 2, followed by 4. 8 million IU/m2/day, 5 days per week for 6 consecutive weeks.", "output": {"entities": {"gene": [{"text": "rIL-2", "start": 59, "end": 64}, {"text": "rIFN-alpha 2b", "start": 174, "end": 187}, {"text": "rIFN-alpha 2b", "start": 290, "end": 303}, {"text": "rIL-2", "start": 351, "end": 356}]}}, "schema": []}
{"input": "At the MTD (8 mg/m2/day), the dose-limiting toxicity of this agent is myelosuppression.", "output": {"entities": {}}, "schema": []}
{"input": "Mitogen-induced lymphocyte proliferation was diminished.", "output": {"entities": {}}, "schema": []}
{"input": "A decanucleotide promoter sequence homologous to those found in humans and mice was located in the 5' untranslated region of one horse gene.", "output": {"entities": {}}, "schema": []}
{"input": "Some of these targets were reported to code for molecules involved in cell-cell interactions, whereas no relationship has yet been demonstrated between Hox genes and other transcription factors involved in determining and/or maintaining tissue specificity.", "output": {"entities": {"gene": [{"text": "Hox genes", "start": 152, "end": 161}]}}, "schema": []}
{"input": "HER2 overexpressing cells showed a single prominent DNase I hypersensitive site near a conserved and hitherto unrecognized ets response element (GAGGAA), located 38 bases down-stream from the CAAT box and directly 5' of the TATA box in the human HER2 promoter.", "output": {"entities": {"gene": [{"text": "HER2", "start": 0, "end": 4}, {"text": "DNase I", "start": 52, "end": 59}, {"text": "ets", "start": 123, "end": 126}, {"text": "human HER2 promoter", "start": 240, "end": 259}]}}, "schema": []}
{"input": "Gel-shift assays with nuclear extracts and oligonucleotide sequences spanning the 0. 125-kb promoter region detected an ETS-immunoreactive complex, present most abundantly in cells overexpressing HER2, whose high-affinity binding depended on the GAGGAA response element.", "output": {"entities": {"gene": [{"text": "ETS", "start": 120, "end": 123}, {"text": "HER2", "start": 196, "end": 200}]}}, "schema": []}
{"input": "Comparison of cDNA sequences revealed that the two mRNA species arise as a result of alternate use of poly (A)-addition sites.", "output": {"entities": {}}, "schema": []}
{"input": "The gene for the RNA-dependent eIF-2 alpha protein kinase (PKR) was isolated from mouse genomic DNA and characterized.", "output": {"entities": {"gene": [{"text": "RNA-dependent eIF-2 alpha protein kinase", "start": 17, "end": 57}, {"text": "PKR", "start": 59, "end": 62}]}}, "schema": []}
{"input": "High-frequency electrical stimulation in the hippocampus leads to an increase in synaptic efficacy that lasts for many hours.", "output": {"entities": {}}, "schema": []}
{"input": "Similar to the mouse gene, the 5' flanking region of human CD79 alpha lacks a TATA box; however, unlike mouse CD79 alpha, a classical octamer motif could not be identified in the human gene.", "output": {"entities": {"gene": [{"text": "human CD79 alpha", "start": 53, "end": 69}, {"text": "mouse CD79 alpha", "start": 104, "end": 120}]}}, "schema": []}
{"input": "Detailed molecular organization of the coding and upstream regulatory regions of the murine homeodomain-containing gene, Msx-1, is reported.", "output": {"entities": {"gene": [{"text": "homeodomain-containing gene", "start": 92, "end": 119}, {"text": "Msx-1", "start": 121, "end": 126}]}}, "schema": []}
{"input": "We report here the cloning of the human goosecoid gene (GSC) from a genomic library and the sequence of its encoded protein.", "output": {"entities": {"gene": [{"text": "human goosecoid gene", "start": 34, "end": 54}, {"text": "GSC", "start": 56, "end": 59}]}}, "schema": []}
{"input": "This virus is not merely a South African strain of passion fruit woodiness virus (PWV): the deduced CP sequence is only distantly related to CPs of other sequenced strains of PWV, although it is part of a distinct subgroup of potyviruses related to PWV.", "output": {"entities": {"gene": [{"text": "CP sequence", "start": 100, "end": 111}, {"text": "CPs", "start": 141, "end": 144}]}}, "schema": []}
{"input": "The ratio of the activity of arogenate dehydrogenase to that of prephenate dehydrogenase (approximately 3: 1) remained constant throughout purification, and the two activities were therefore inseparable.", "output": {"entities": {"gene": [{"text": "arogenate dehydrogenase", "start": 29, "end": 52}, {"text": "prephenate dehydrogenase", "start": 64, "end": 88}]}}, "schema": []}
{"input": "A leucine zipper domain of the suppressor of Hairy-wing protein mediates its repressive effect on enhancer function.", "output": {"entities": {"gene": [{"text": "suppressor of Hairy-wing protein", "start": 31, "end": 63}]}}, "schema": []}
{"input": "It is concluded that CT should be routinely employed in patients with N1-N3 neck disease to determine the proper electron-energy prescription.", "output": {"entities": {}}, "schema": []}
{"input": "The predicted DNA-binding, zinc finger domain protein sequence was strictly conserved.", "output": {"entities": {"gene": [{"text": "zinc finger domain protein", "start": 27, "end": 53}]}}, "schema": []}
{"input": "60 patients were entered into a randomised study comparing vindesine (3 mg/m2/week) plus interferon-alpha 2b (6 U/m2 3 times per week) to vindesine alone or to interferon alone for the treatment of metastatic malignant melanoma.", "output": {"entities": {"gene": [{"text": "interferon-alpha 2b", "start": 89, "end": 108}, {"text": "interferon", "start": 160, "end": 170}]}}, "schema": []}
{"input": "BACKGROUND: We conducted a phase I study with MDL 73, 147EF, a new 5 hydroxytryptamine 3 (5-HT3) receptor antagonist, in 25 patients requiring emetogenic chemotherapy.", "output": {"entities": {"gene": [{"text": "5 hydroxytryptamine 3 (5-HT3) receptor", "start": 67, "end": 105}]}}, "schema": []}
{"input": "In the presence of the in vivo reducing system (thioredoxin, thioredoxin reductase, and NADPH), however, each of these mutants catalyzed the formation of only 0. 6-0. 8 dCTPs per mole of enzyme.", "output": {"entities": {"gene": [{"text": "thioredoxin", "start": 48, "end": 59}, {"text": "thioredoxin reductase", "start": 61, "end": 82}]}}, "schema": []}
{"input": "These genetic alterations do not affect synthesis of the major c-myc protein, p64, which is initiated from the first AUG codon in exon 2.", "output": {"entities": {"gene": [{"text": "c-myc protein", "start": 63, "end": 76}, {"text": "p64", "start": 78, "end": 81}]}}, "schema": []}
{"input": "In addition, both the exon 1-and exon 2-initiated forms of the c-Myc protein stimulated transcription of a Myc/Max-responsive reporter construct to a similar level.", "output": {"entities": {"gene": [{"text": "c-Myc protein", "start": 63, "end": 76}, {"text": "Myc", "start": 107, "end": 110}, {"text": "Max", "start": 111, "end": 114}]}}, "schema": []}
{"input": "Biological activities of hematopoietic growth factors that lead to future clinical application.", "output": {"entities": {"gene": [{"text": "hematopoietic growth factors", "start": 25, "end": 53}]}}, "schema": []}
{"input": "Expression is exclusively limited to the CNS at this and later stages.", "output": {"entities": {}}, "schema": []}
{"input": "Disruption of any one of the four genes encoding the newly identified SRP proteins results in slow cell growth and inefficient protein translocation across the ER membrane.", "output": {"entities": {"gene": [{"text": "SRP proteins", "start": 70, "end": 82}]}}, "schema": []}
{"input": "Genetic alterations in elements of normal signal transduction mechanisms are known to be oncogenic events often resulting in aberrant activation of programs of gene transcription.", "output": {"entities": {}}, "schema": []}
{"input": "The expression pattern of GL2, as demonstrated by in situ hybridization, indicated that the gene is expressed in trichome progenitor cells and at stages associated with trichome development.", "output": {"entities": {"gene": [{"text": "GL2", "start": 26, "end": 29}]}}, "schema": []}
{"input": "NOT4 interacts with NOT1 and NOT3 in the two-hybrid assay, and overexpression of NOT3 or NOT4 suppresses not1 and not2 mutations.", "output": {"entities": {"gene": [{"text": "NOT4", "start": 0, "end": 4}, {"text": "NOT1", "start": 20, "end": 24}, {"text": "NOT3", "start": 29, "end": 33}, {"text": "NOT3", "start": 81, "end": 85}, {"text": "NOT4", "start": 89, "end": 93}, {"text": "not1", "start": 105, "end": 109}, {"text": "not2", "start": 114, "end": 118}]}}, "schema": []}
{"input": "Binding site selection using in vitro-synthesized proteins reveals that the ROR alpha 1 and ROR alpha 2 isoforms bind DNA as monomers to hormone response elements composed of a 6-bp AT-rich sequence preceding a half-site core motif PuGGTCA (RORE).", "output": {"entities": {"gene": [{"text": "ROR alpha 1", "start": 76, "end": 87}, {"text": "ROR alpha 2 isoforms", "start": 92, "end": 112}, {"text": "RORE", "start": 241, "end": 245}]}}, "schema": []}
{"input": "The p73pct1/p85cdc10 complex binds both in vitro and in vivo to MCB but not SCB or E2F sites.", "output": {"entities": {"gene": [{"text": "p73pct1", "start": 4, "end": 11}, {"text": "p85cdc10", "start": 12, "end": 20}, {"text": "MCB", "start": 64, "end": 67}, {"text": "SCB", "start": 76, "end": 79}, {"text": "E2F sites", "start": 83, "end": 92}]}}, "schema": []}
{"input": "We show that the en stripes expand anteriorly in slp mutant embryos and that slp activity is an absolute requirement for maintenance of wg expression at the same time that wg transcription is dependent on hh.", "output": {"entities": {"gene": [{"text": "en", "start": 17, "end": 19}, {"text": "slp", "start": 49, "end": 52}, {"text": "slp", "start": 77, "end": 80}, {"text": "wg", "start": 136, "end": 138}, {"text": "wg", "start": 172, "end": 174}, {"text": "hh", "start": 205, "end": 207}]}}, "schema": []}
{"input": "The DNA sequence adjacent to the lacZ gene has been determined for 91 vegetative fusion genes whose products have been localized and for 43 meiotically induced fusions.", "output": {"entities": {"gene": [{"text": "lacZ gene", "start": 33, "end": 42}]}}, "schema": []}
{"input": "CMV hyperimmunoglobulin treatment (Cytotect, Biotest) was started (2 ml/kg bw on day 1 and 3, and 1 ml/kg on days 5, 7 and 9), which led to the eradication of the residual infiltrate and CMV-DNA in the myocardium.", "output": {"entities": {"gene": [{"text": "hyperimmunoglobulin", "start": 4, "end": 23}]}}, "schema": []}
{"input": "In eight groups of subjects operating various hand-held vibrating tools and aged from 30 to 59 years, the prevalence rates of vibration-induced white finger (VWF) and numbness, pain, or stiffness in the upper and lower extremities were investigated.", "output": {"entities": {}}, "schema": []}
{"input": "DNA sequence analysis showed that the gene was 525 bp long and encoded a 175-amino-acid protein with a molecular weight of 19, 094 containing a 21-residue typical lipoprotein signal peptide and consensus prolipoprotein processing site.", "output": {"entities": {}}, "schema": []}
{"input": "DNA sequence and functions of the actVI region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3 (2).", "output": {"entities": {"gene": [{"text": "actVI region", "start": 34, "end": 46}, {"text": "actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3 (2)", "start": 54, "end": 126}]}}, "schema": []}
{"input": "(1992) Genomics 12, 58-62).", "output": {"entities": {}}, "schema": []}
{"input": "A comparison of the predicted polypeptide sequence of the Drosophila protein with the equivalent subunits from mouse and yeast suggests that they are closely related and defines three conserved regions which are likely to be important for enzyme activity.", "output": {"entities": {}}, "schema": []}
{"input": "Cytoplasmic dynein is a multisubunit, microtubule-dependent mechanochemical enzyme that has been proposed to function in a variety of intracellular movements, including minus-end-directed transport of organelles.", "output": {"entities": {"gene": [{"text": "Cytoplasmic dynein", "start": 0, "end": 18}]}}, "schema": []}
{"input": "Identification of the plakoglobin-binding domain in desmoglein and its role in plaque assembly and intermediate filament anchorage.", "output": {"entities": {"gene": [{"text": "plakoglobin", "start": 22, "end": 33}, {"text": "desmoglein", "start": 52, "end": 62}]}}, "schema": []}
{"input": "PATIENTS AND METHODS: One hundred eighty-four chemotherapy-naive patients receiving high-dose cisplatin (81 to 120 mg/m2) were randomized to receive one of four granisetron doses (5, 10, 20, or 40 micrograms/kg) administered before chemotherapy.", "output": {"entities": {}}, "schema": []}
{"input": "Nine new naphthalene related compounds (I, IV, V, VII-XII) together with four known compounds (II, III, VI, XIII) were isolated from the root bark of Oroxylum indicum Vent.", "output": {"entities": {}}, "schema": []}
{"input": "As shown previously, EBNA2 transactivates the promoters of the viral latent membrane proteins.", "output": {"entities": {"gene": [{"text": "EBNA2", "start": 21, "end": 26}, {"text": "viral latent membrane proteins", "start": 63, "end": 93}]}}, "schema": []}
{"input": "We previously showed that v-Rel, the oncoprotein of the avian retrovirus Rev-T, can increase expression from promoters containing binding sites for the cellular transcription factor Sp1 in chicken embryo fibroblasts (S.", "output": {"entities": {"gene": [{"text": "v-Rel", "start": 26, "end": 31}, {"text": "Sp1", "start": 182, "end": 185}]}}, "schema": []}
{"input": "Previous studies have demonstrated that the TATA element is critical for basal and Tat-induced HIV-1 gene expression.", "output": {"entities": {"gene": [{"text": "Tat", "start": 83, "end": 86}]}}, "schema": []}
{"input": "A comparison of the nucleotide sequence of the p54 gene carried by two virulent ASFV strains (E70 and E75) with that obtained from virus Ba71V showed 100% similarity.", "output": {"entities": {"gene": [{"text": "p54 gene", "start": 47, "end": 55}]}}, "schema": []}
{"input": "The p55 mRNA is undetectable in non-EBV-infected B-and T-cell lines or in a myelomonocytic cell line (U937).", "output": {"entities": {"gene": [{"text": "p55 mRNA", "start": 4, "end": 12}]}}, "schema": []}
{"input": "A simple registration as an incentive for improvement", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: The diagnostic quality of FDG images was at least as good as that of their Tl-201 counterparts, with less liver background in all but one FDG study.", "output": {"entities": {}}, "schema": []}
{"input": "The coordinated expression of CD4 and CD8 during T-cell development is tightly coupled with the maturation state of the T cell.", "output": {"entities": {"gene": [{"text": "CD4", "start": 30, "end": 33}, {"text": "CD8", "start": 38, "end": 41}]}}, "schema": []}
{"input": "The dying tTG-transfected cells exhibit both cytoplasmic and nuclear changes characteristic of cells undergoing apoptosis.", "output": {"entities": {"gene": [{"text": "tTG", "start": 10, "end": 13}]}}, "schema": []}
{"input": "Using an RNase H-mediated mapping technique, we show that the 64-kDa subunit of CstF can be photo cross-linked to pre-mRNAs at U-rich regions located downstream of the cleavage site of the simian virus 40 late and adenovirus L3 pre-mRNAs.", "output": {"entities": {"gene": [{"text": "RNase H", "start": 9, "end": 16}, {"text": "CstF", "start": 80, "end": 84}, {"text": "adenovirus L3 pre-mRNAs", "start": 214, "end": 237}]}}, "schema": []}
{"input": "The protein encoded is 114 kDa and contains eight zinc finger motifs, seven of which are present in two clusters at opposite ends of the molecule.", "output": {"entities": {}}, "schema": []}
{"input": "Tissue-specific expression of the diazepam-binding inhibitor in Drosophila melanogaster: cloning, structure, and localization of the gene.", "output": {"entities": {"gene": [{"text": "diazepam-binding inhibitor", "start": 34, "end": 60}]}}, "schema": []}
{"input": "Using a v-erbA probe, we obtained a cDNA which encodes a novel 445-amino-acid protein, RLD-1, that contains the characteristic domains of nuclear receptors.", "output": {"entities": {"gene": [{"text": "v-erbA", "start": 8, "end": 14}, {"text": "RLD-1", "start": 87, "end": 92}]}}, "schema": []}
{"input": "Only two of the isoforms possess the N-terminal zinc finger domain that is necessary and sufficient for TdT promoter binding.", "output": {"entities": {"gene": [{"text": "TdT promoter", "start": 104, "end": 116}]}}, "schema": []}
{"input": "This study provides direct evidence that USF, a member of the basic helix-loop-helix leucine zipper family, binds to MLE1, HF-1a, and PRE B sites and suggests that it is a component of protein complexes that may coordinately control the expression of MLC-2v and alpha-myosin heavy-chain genes.", "output": {"entities": {"gene": [{"text": "USF", "start": 41, "end": 44}, {"text": "basic helix-loop-helix leucine zipper family", "start": 62, "end": 106}, {"text": "MLE1", "start": 117, "end": 121}, {"text": "HF-1a", "start": 123, "end": 128}, {"text": "PRE B sites", "start": 134, "end": 145}, {"text": "MLC-2v", "start": 251, "end": 257}, {"text": "alpha-myosin heavy-chain genes", "start": 262, "end": 292}]}}, "schema": []}
{"input": "Activation of c-fos gene expression by a kinase-deficient epidermal growth factor receptor.", "output": {"entities": {"gene": [{"text": "c-fos gene", "start": 14, "end": 24}, {"text": "epidermal growth factor receptor", "start": 58, "end": 90}]}}, "schema": []}
{"input": "Because endogenous HSF DNA-binding activity is low and anti-hHSF1 antibody does not recognize Xenopus HSF, we employed this system for mapping regions in hHSF1 that are required for the maintenance of the monomeric state.", "output": {"entities": {"gene": [{"text": "HSF", "start": 19, "end": 22}, {"text": "anti-hHSF1 antibody", "start": 55, "end": 74}, {"text": "Xenopus HSF", "start": 94, "end": 105}, {"text": "hHSF1", "start": 154, "end": 159}]}}, "schema": []}
{"input": "Enhancers containing disrupted Ets-1 binding sites were tested in transient expression assays in the murine T-cell line EL4. E1; alterations in the LVb element affected constitutive enhancer activity, while mutation of either the LVb or LVc element disrupted phorbol ester-induced enhancer activity.", "output": {"entities": {"gene": [{"text": "Ets-1 binding sites", "start": 31, "end": 50}]}}, "schema": []}
{"input": "The predominant binding activity was not Ets-1 but rather two independent DNA-protein complexes that comigrated in mobility shift assays.", "output": {"entities": {"gene": [{"text": "Ets-1", "start": 41, "end": 46}]}}, "schema": []}
{"input": "Treatment with amphotericin B and flucytosine led to improvement of the symptoms but did not eradicate the micro-organisms from the cerebrospinal fluid (CSF).", "output": {"entities": {}}, "schema": []}
{"input": "The unexpected presence of the tRNA (trp) (CCA)-gene transcript in mitochondria is also reported.", "output": {"entities": {"gene": [{"text": "tRNA (trp) (CCA)-gene transcript in mitochondria", "start": 31, "end": 79}]}}, "schema": []}
{"input": "The parameters of nonspecific humoral immunity--serum immunoglobulins and immune complexes--were evaluated in irradiated group of patients with uterine cervix carcinoma (Stages IIB and IIIB), during one year follow up.", "output": {"entities": {"gene": [{"text": "serum immunoglobulins", "start": 48, "end": 69}]}}, "schema": []}
{"input": "Mutation of KRKR to NGER retains MO15 in the cytoplasmic compartment, whilst the wild-type protein is detected exclusively in the nucleus.", "output": {"entities": {"gene": [{"text": "MO15", "start": 33, "end": 37}]}}, "schema": []}
{"input": "To confirm the binding of protein to these sites in cells, we carried out an in vivo genomic footprinting analysis of this portion of the TGF alpha promoter in normal and transformed rat liver epithelial cell lines that express the endogenous gene at varying levels.", "output": {"entities": {"gene": [{"text": "TGF alpha promoter", "start": 138, "end": 156}]}}, "schema": []}
{"input": "Strikingly, this subdomain is also present in the otherwise unrelated N-terminal activating region of p58c-ets-2 and was thus named BEC for Ets-1-beta/Ets-2-Conserved sequence.", "output": {"entities": {"gene": [{"text": "p58c-ets-2", "start": 102, "end": 112}, {"text": "BEC", "start": 132, "end": 135}, {"text": "Ets-1-beta", "start": 140, "end": 150}, {"text": "Ets-2-Conserved sequence", "start": 151, "end": 175}]}}, "schema": []}
{"input": "This work unravels a new model for the ets-1/ets-2 gene' s evolution, based for the first time on both structural and functional evidences.", "output": {"entities": {"gene": [{"text": "ets-1", "start": 39, "end": 44}, {"text": "ets-2 gene", "start": 45, "end": 55}]}}, "schema": []}
{"input": "The v-ets oncogene of the avian retrovirus E26 differs from its cellular progenitor p68c-ets-1 by two amino acid substitutions (alanine 285 and isoleucine 445 in c-ets-1 both substituted by valine in v-ets, mutations A and B respectively) and its carboxy-terminal end (mutation C).", "output": {"entities": {"gene": [{"text": "v-ets oncogene", "start": 4, "end": 18}, {"text": "p68c-ets-1", "start": 84, "end": 94}, {"text": "c-ets-1", "start": 162, "end": 169}, {"text": "v-ets", "start": 200, "end": 205}]}}, "schema": []}
{"input": "Consequently functional mRNAs can be produced by endogenous RNA polymerase I.", "output": {"entities": {"gene": [{"text": "endogenous RNA polymerase", "start": 49, "end": 74}]}}, "schema": []}
{"input": "The individual subunits of Ku have been difficult to isolate from human cells without denaturation and attempts to produce functional recombinant Ku have been largely unsuccessful.", "output": {"entities": {"gene": [{"text": "Ku", "start": 27, "end": 29}, {"text": "functional recombinant Ku", "start": 123, "end": 148}]}}, "schema": []}
{"input": "Using this method, we were able to select strong enhancer-type activation domains from the immediate early regions of two herpesviruses, namely pseudorabies virus and bovine herpesvirus 1.", "output": {"entities": {"gene": [{"text": "immediate early regions", "start": 91, "end": 114}]}}, "schema": []}
{"input": "A genetic system was devised to select for pi protein mutants which discriminate between IR and DR (York et al., Gene (Amst.) 116, 7-12, 1992; York and Filutowicz, J.", "output": {"entities": {"gene": [{"text": "pi protein mutants", "start": 43, "end": 61}]}}, "schema": []}
{"input": "Univariate statistical analysis based on Kaplan-Meier-estimates and Log-Rank-Test showed the following prognostically beneficial factors: Limited disease stage (p = 0. 009), NSE serum level less than 25 micrograms/l (p = 0. 016), serum alkaline phosphatase less than 200 U/l (p = 0. 035), normal serum albumin (p = 0. 003) and activity index of minimum of 70 (p < 0. 001).", "output": {"entities": {"gene": [{"text": "NSE", "start": 174, "end": 177}, {"text": "alkaline phosphatase", "start": 236, "end": 256}, {"text": "albumin", "start": 302, "end": 309}]}}, "schema": []}
{"input": "HBx strongly elevates levels of GTP-bound Ras, activated and phosphorylated Raf, and tyrosine-phosphorylated and activated MAP kinase.", "output": {"entities": {"gene": [{"text": "HBx", "start": 0, "end": 3}, {"text": "Ras", "start": 42, "end": 45}, {"text": "Raf", "start": 76, "end": 79}, {"text": "MAP kinase", "start": 123, "end": 133}]}}, "schema": []}
{"input": "Role of c-myc in simian virus 40 large tumor antigen-induced DNA synthesis in quiescent 3T3-L1 mouse fibroblasts.", "output": {"entities": {"gene": [{"text": "c-myc", "start": 8, "end": 13}, {"text": "simian virus 40 large tumor antigen", "start": 17, "end": 52}]}}, "schema": []}
{"input": "Laser therapy of penile carcinoma", "output": {"entities": {}}, "schema": []}
{"input": "A 15. 1 kb fragment of the yeast genome was allocated to the centromeric region of chromosome XIV by genetic mapping.", "output": {"entities": {}}, "schema": []}
{"input": "A third one is homologous in half of its length to the prokaryotic hydantoinase HyuA and in the other half to hydatoinase HyuB.", "output": {"entities": {"gene": [{"text": "prokaryotic hydantoinase HyuA", "start": 55, "end": 84}, {"text": "hydatoinase HyuB", "start": 110, "end": 126}]}}, "schema": []}
{"input": "It was shown that estradiol concentrations obtained after estradiol valerate and micronized estradiol ingestion were dependent on the patient' s age as well as on the constitutional type.", "output": {"entities": {}}, "schema": []}
{"input": "Constipation is not a risk factor for hemorrhoids: a case-control study of potential etiological agents.", "output": {"entities": {}}, "schema": []}
{"input": "Of 419 persons surveyed, 207 (49. 4%) were antigen-positive with the Og4C3 assay.", "output": {"entities": {"gene": [{"text": "Og4C3", "start": 69, "end": 74}]}}, "schema": []}
{"input": "Vibrio cholerae O139 in Calcutta.", "output": {"entities": {}}, "schema": []}
{"input": "Sequence analysis of the zebrafish egr1 coding region revealed a high level of homology to the mouse, rat, and human Egr1 genes with the notable exception of a polymorphic, triplet nucleotide repeat sequence in the region coding for the amino terminus of the Egr1 protein.", "output": {"entities": {"gene": [{"text": "zebrafish egr1 coding region", "start": 25, "end": 53}, {"text": "human Egr1 genes", "start": 111, "end": 127}, {"text": "Egr1 protein", "start": 259, "end": 271}]}}, "schema": []}
{"input": "The fibrinogen, serum proteins, sodium heparin and membrane contributed to Cm by 20%, 14%, 2% and 64%, respectively.", "output": {"entities": {"gene": [{"text": "fibrinogen", "start": 4, "end": 14}]}}, "schema": []}
{"input": "In these vectors the chimeric long terminal repeat (chLTR) drives the expression of the chloramphenicol acetyl transferase (CAT) reporter gene that is followed by an internal SV40 virus early region promoter linked to the neomycin phosphotransferase II (NEO) gene.", "output": {"entities": {"gene": [{"text": "chimeric long terminal repeat", "start": 21, "end": 50}, {"text": "chLTR", "start": 52, "end": 57}, {"text": "chloramphenicol acetyl transferase", "start": 88, "end": 122}, {"text": "CAT", "start": 124, "end": 127}, {"text": "SV40 virus early region promoter", "start": 175, "end": 207}, {"text": "neomycin phosphotransferase II", "start": 222, "end": 252}, {"text": "NEO", "start": 254, "end": 257}]}}, "schema": []}
{"input": "Optima) genomic library by hybridizing with elicitor-induced stilbene synthase cDNA as a probe.", "output": {"entities": {"gene": [{"text": "stilbene synthase cDNA", "start": 61, "end": 83}]}}, "schema": []}
{"input": "A total of 125 acute leukemia adult patients were autografted with bone marrow (BM) purged by mafosfamide (ASTA Z) during the period of January 1983 to January 1993.", "output": {"entities": {}}, "schema": []}
{"input": "The pretransplant regimen consisted of cyclophosphamide (120 mg/kg) and total body irradiation.", "output": {"entities": {}}, "schema": []}
{"input": "The site-directed mutation of the kappa B motif in IL-6/CAT plasmid resulted in the complete abrogation of IL-6 promoter activity in these cells.", "output": {"entities": {"gene": [{"text": "kappa B motif", "start": 34, "end": 47}, {"text": "IL-6", "start": 51, "end": 55}, {"text": "CAT", "start": 56, "end": 59}, {"text": "IL-6 promoter", "start": 107, "end": 120}]}}, "schema": []}
{"input": "Curiously, testololactone was earlier and more widely used than aminoglutethimide in treating advanced breast carcinoma.", "output": {"entities": {}}, "schema": []}
{"input": "Use of the vena cava to extend the right renal vein for cadaver transplantation is controversial.", "output": {"entities": {}}, "schema": []}
{"input": "Enhanced hepatic portal blood flow induced by prostaglandin E1 following liver transplantation in pigs.", "output": {"entities": {}}, "schema": []}
{"input": "One gene appears ubiquitously expressed while the other is prominently expressed in muscle.", "output": {"entities": {}}, "schema": []}
{"input": "For HeLa, 293, U937, and A549 cells, participation of E2F-1, DP-1, cyclin A, and RB was involved in formation of some complexes only, assuming participation of factors different from E2F-1 or DP-1 in others.", "output": {"entities": {"gene": [{"text": "E2F-1", "start": 54, "end": 59}, {"text": "DP-1", "start": 61, "end": 65}, {"text": "cyclin A", "start": 67, "end": 75}, {"text": "RB", "start": 81, "end": 83}, {"text": "E2F-1", "start": 183, "end": 188}, {"text": "DP-1", "start": 192, "end": 196}]}}, "schema": []}
{"input": "E1A autoactivation mediated by these sites was about twofold compared with a ninefold activation described for the complete E1A promoter.", "output": {"entities": {"gene": [{"text": "E1A", "start": 0, "end": 3}, {"text": "E1A promoter", "start": 124, "end": 136}]}}, "schema": []}
{"input": "Cestode invasion in irradiated host organism increases the negative effect of ionizing radiation on the hamster immune system.", "output": {"entities": {}}, "schema": []}
{"input": "During heat exposure, chicks that had been subjected to early 60% restriction with non-metyrapone-treated food had lower H/L ratios and improved resistance to marble spleen disease infection.", "output": {"entities": {}}, "schema": []}
{"input": "Analyses of additional tumors induced in mice from two reciprocal crosses, A/J x C3H/HeJ F1 (hereafter called AC3F1) and C3H/HeJ x A/J F1 (hereafter called C3AF1), provided evidence for the inactivation of one allele of the putative chromosome 4 tumor suppressor gene by parental imprinting.", "output": {"entities": {}}, "schema": []}
{"input": "ERV1 is involved in the cell-division cycle and the maintenance of mitochondrial genomes in Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "ERV1", "start": 0, "end": 4}]}}, "schema": []}
{"input": "Lesion diameters of greater than 20 mm and the large sessile-type configurations were factors that were associated with incomplete removal.", "output": {"entities": {}}, "schema": []}
{"input": "Routinely collected, processed and stored breast cancer tissue blocks recovered from the archives of the Pathology laboratory in Dar es Salaam after storage of up to 3 years were analysed by a flow cytometry for DNA ploidy and S-phase fraction.", "output": {"entities": {}}, "schema": []}
{"input": "Cbf3 contains three proteins, Cbf3a, Cbf3b and Cbf3c.", "output": {"entities": {"gene": [{"text": "Cbf3", "start": 0, "end": 4}, {"text": "Cbf3a", "start": 30, "end": 35}, {"text": "Cbf3b", "start": 37, "end": 42}, {"text": "Cbf3c", "start": 47, "end": 52}]}}, "schema": []}
{"input": "Such an interaction could be detected using a GST-POU fusion protein bound to glutathione-agarose beads.", "output": {"entities": {"gene": [{"text": "GST", "start": 46, "end": 49}, {"text": "POU", "start": 50, "end": 53}]}}, "schema": []}
{"input": "These mutations are localized in the same region where the HSV transactivator VP16 binds, but did not coincide with the VP16 contacts.", "output": {"entities": {"gene": [{"text": "HSV transactivator VP16", "start": 59, "end": 82}, {"text": "VP16", "start": 120, "end": 124}]}}, "schema": []}
{"input": "Notably, these residues are located in different domains.", "output": {"entities": {}}, "schema": []}
{"input": "However, rapamycin inhibited proliferation of Ba/F3-EpoRgp55 but not of MEL cells despite inhibition of p70 S6 kinase activity in both cells.", "output": {"entities": {"gene": [{"text": "p70 S6 kinase", "start": 104, "end": 117}]}}, "schema": []}
{"input": "Intraventricular injection of (2S, 1' R, 2' R, 3' R)-2-(2, 3-dicarboxycyclopropyl) glycine (DCG-IV), a potent agonist for metabotropic glutamate receptors, to rats retarded dose-dependently the recovery from halothane anesthesia at a dose range from 30 to 300 pmol/rat.", "output": {"entities": {"gene": [{"text": "glutamate receptors", "start": 135, "end": 154}]}}, "schema": []}
{"input": "The hepatocyte nuclear factor-3 (HNF-3)/forkhead (fkh) proteins consist of an extensive family of tissue-specific and developmental gene regulators which share homology within the winged helix DNA binding motif.", "output": {"entities": {"gene": [{"text": "hepatocyte nuclear factor-3", "start": 4, "end": 31}, {"text": "HNF-3", "start": 33, "end": 38}, {"text": "forkhead", "start": 40, "end": 48}, {"text": "fkh", "start": 50, "end": 53}]}}, "schema": []}
{"input": "Interestingly, dTFIIA-L/S is also able to significantly enhance transcriptional activation by upstream transcription factors including Sp1, VP16, and NTF-1.", "output": {"entities": {"gene": [{"text": "dTFIIA-L/S", "start": 15, "end": 25}, {"text": "Sp1", "start": 135, "end": 138}, {"text": "VP16", "start": 140, "end": 144}, {"text": "NTF-1", "start": 150, "end": 155}]}}, "schema": []}
{"input": "In particular, changes in intracellular Ca2 + have the potential to either inhibit or augment the ability of cAMP to stimulate transcription, depending on the presence of specific forms of Ca2 +/calmodulin-dependent protein kinases.", "output": {"entities": {"gene": [{"text": "Ca2 +/calmodulin-dependent protein kinases", "start": 189, "end": 231}]}}, "schema": []}
{"input": "Antibodies directed against the SNM1 protein immunoprecipitated RNase MRP RNA from whole-cell extracts without precipitating the structurally and functionally related RNase P RNA.", "output": {"entities": {"gene": [{"text": "SNM1 protein", "start": 32, "end": 44}, {"text": "RNase MRP RNA", "start": 64, "end": 77}, {"text": "RNase P RNA", "start": 167, "end": 178}]}}, "schema": []}
{"input": "Our results show that the ORF of hAMPK encodes 552 amino acids (aa) (62. 250 kDa) and is highly conserved with rAMPK with identities of 97. 3 and 90% at the aa and nt levels, respectively.", "output": {"entities": {"gene": [{"text": "hAMPK", "start": 33, "end": 38}, {"text": "rAMPK", "start": 111, "end": 116}]}}, "schema": []}
{"input": "In human brain, contactin was first identified by amino terminal and peptide sequencing of the lentil-lectin-binding glycoprotein Gp135.", "output": {"entities": {"gene": [{"text": "contactin", "start": 16, "end": 25}, {"text": "lentil-lectin-binding glycoprotein Gp135", "start": 95, "end": 135}]}}, "schema": []}
{"input": "The centromeric YAC contig, which consists of 23 overlapping YACs and orders 19 sequence-tagged sites (STSs), covers a minimum of 2. 2 Mb and spans the Ewing sarcoma breakpoint. c-ets 1 and Fli-1, two members of the ets family, have been linked within 400 kb of intervening DNA within this contig, which also comprises a polymorphic microsatellite, D11S912 (CA) n, which we have localized within the Fli-1 gene.", "output": {"entities": {"gene": [{"text": "c-ets 1", "start": 178, "end": 185}, {"text": "Fli-1", "start": 190, "end": 195}, {"text": "ets family", "start": 216, "end": 226}, {"text": "D11S912", "start": 349, "end": 356}, {"text": "Fli-1 gene", "start": 400, "end": 410}]}}, "schema": []}
{"input": "A cDNA for a newly discovered pseudogene, closely related to the mouse mast cell chymases was isolated by polymerase chain reaction amplification from a mouse connective tissue-like mast cell line.", "output": {"entities": {"gene": [{"text": "mouse mast cell chymases", "start": 65, "end": 89}]}}, "schema": []}
{"input": "IFI16 consists of ten exons and nine intervening introns spanning at least 28 kilobases (kb) of DNA.", "output": {"entities": {"gene": [{"text": "IFI16", "start": 0, "end": 5}]}}, "schema": []}
{"input": "Courses were repeated every four weeks.", "output": {"entities": {}}, "schema": []}
{"input": "Peter Elfer explores the implications of the ruling.", "output": {"entities": {}}, "schema": []}
{"input": "Other adverse events with incidences significantly higher than with placebo were dizziness, constipation, sweating, nervousness, and abnormal ejaculation.", "output": {"entities": {}}, "schema": []}
{"input": "Homology was also detected between the putative transit peptide sequence of cysteine synthase C and other mitochondrion-targeting leader sequences.", "output": {"entities": {"gene": [{"text": "cysteine synthase C", "start": 76, "end": 95}]}}, "schema": []}
{"input": "Furthermore, our data also show that, in addition to TEF-1, another HF-1a-related factor may be recognized by the alpha-MHC gene EM element.", "output": {"entities": {"gene": [{"text": "TEF-1", "start": 53, "end": 58}, {"text": "HF-1a-related factor", "start": 68, "end": 88}, {"text": "alpha-MHC gene", "start": 114, "end": 128}]}}, "schema": []}
{"input": "Rat kidney carboxylesterase.", "output": {"entities": {"gene": [{"text": "Rat kidney carboxylesterase", "start": 0, "end": 27}]}}, "schema": []}
{"input": "Recombinant I-kappa B alpha inhibited kappa B motif binding by nuclear factor-kappa B1, RelA, and c-Rel as indicated by studies using UV radiation-induced covalent cross-linking to a bromodeoxyuridine-substituted kappa B oligonucleotide.", "output": {"entities": {"gene": [{"text": "Recombinant I-kappa B alpha", "start": 0, "end": 27}, {"text": "kappa B motif", "start": 38, "end": 51}, {"text": "nuclear factor-kappa B1", "start": 63, "end": 86}, {"text": "RelA", "start": 88, "end": 92}, {"text": "c-Rel", "start": 98, "end": 103}, {"text": "kappa B oligonucleotide", "start": 213, "end": 236}]}}, "schema": []}
{"input": "The physical and chemical stability of a combination of drugs commonly administered into the epidural or intrathecal space for the treatment of chronic pain was investigated.", "output": {"entities": {}}, "schema": []}
{"input": "Therefore, mechanisms that control activation of the MAP kinase cascade temporally and spatially may be important for specification of cellular responses.", "output": {"entities": {"gene": [{"text": "MAP kinase", "start": 53, "end": 63}]}}, "schema": []}
{"input": "A candidate gene for Bcg, designated natural resistance-associated macrophage protein (Nramp), has been isolated and shown to encode a novel macrophage-specific membrane protein, which is altered in susceptible animals.", "output": {"entities": {"gene": [{"text": "Bcg", "start": 21, "end": 24}, {"text": "natural resistance-associated macrophage protein", "start": 37, "end": 85}, {"text": "Nramp", "start": 87, "end": 92}]}}, "schema": []}
{"input": "This motif is similar to but distinct from the LIM domain and the RING finger family, and is reminiscent of known metal-binding regions.", "output": {"entities": {"gene": [{"text": "LIM domain", "start": 47, "end": 57}, {"text": "RING finger family", "start": 66, "end": 84}]}}, "schema": []}
{"input": "The P131 ORF is followed in-frame by a second ORF which is probably expressed by partial readthrough of the UGA termination codon of the P131 ORF to produce a polypeptide of M (r) 191044 (P191).", "output": {"entities": {}}, "schema": []}
{"input": "One hundred fifty patients were reviewed at 1 year after arthroplasty.", "output": {"entities": {}}, "schema": []}
{"input": "Elementary visual hallucinations in migraine and epilepsy.", "output": {"entities": {}}, "schema": []}
{"input": "The influence of patient-related factors on inter-observer variability in the evaluation of neurological signs was investigated.", "output": {"entities": {}}, "schema": []}
{"input": "The defined length of the mRNA, 1, 838 nucleotides, was in agreement with that of a 1. 9-kb RNA expressed throughout the replication cycle, starting at the early stages of infection.", "output": {"entities": {}}, "schema": []}
{"input": "Infect.", "output": {"entities": {}}, "schema": []}
{"input": "Transient transfections of a construct expressing the RNA transcript defined by clone B1. 1 into D17 cells led to the expression of an Env/Mlvi-4 fusion protein with an apparent molecular mass of 33 kDa.", "output": {"entities": {"gene": [{"text": "Env", "start": 135, "end": 138}, {"text": "Mlvi-4", "start": 139, "end": 145}]}}, "schema": []}
{"input": "Roizman, J.", "output": {"entities": {}}, "schema": []}
{"input": "Articles addressing valvular heart disease or heart failure secondary to acute myocardial infarction or Chagas' disease were excluded.", "output": {"entities": {}}, "schema": []}
{"input": "All nuclear receptors have several well-characterized structural domains, including a conserved DNA-binding domain, and a ligand binding domain at the carboxyl terminus of the receptor.", "output": {"entities": {}}, "schema": []}
{"input": "The sample includes all the HIV-infected-patients continuously referred to the Outpatient Service of the Infectious Diseases dept. of Bologna' s \" Ospedale Maggiore \" General Hospital during some five days (19-23rd, July 1993).", "output": {"entities": {}}, "schema": []}
{"input": "Using in organello footprint analysis, we demonstrate that within human placental mitochondria there is a high level of protein-DNA binding at regularly phased intervals throughout a 500-bp region encompassing the D-loop DNA origins and two promoter regions.", "output": {"entities": {}}, "schema": []}
{"input": "The Nur77 protein can act as a potent transcription activator and may function to regulate the expression of downstream genes in response to extracellular stimuli.", "output": {"entities": {"gene": [{"text": "Nur77 protein", "start": 4, "end": 17}]}}, "schema": []}
{"input": "One class of plasmids contained tRNA (His) genes and conferred efficient suppression only when cells were starved for histidine; these plasmids suppressed a gcn2 deletion much less efficiently than they suppressed gcn2-507.", "output": {"entities": {"gene": [{"text": "tRNA (His) genes", "start": 32, "end": 48}, {"text": "gcn2", "start": 157, "end": 161}, {"text": "gcn2-507", "start": 214, "end": 222}]}}, "schema": []}
{"input": "Thus, the presence of the Cln2 PEST domain was sufficient to destabilize a heterologous protein.", "output": {"entities": {"gene": [{"text": "Cln2 PEST domain", "start": 26, "end": 42}]}}, "schema": []}
{"input": "Electrophoretic mobility shift assays with each of these sequences demonstrated complexes with mobilities identical to those of the NF-kappa B site from the kappa light-chain gene.", "output": {"entities": {"gene": [{"text": "NF-kappa B site", "start": 132, "end": 147}, {"text": "kappa light-chain gene", "start": 157, "end": 179}]}}, "schema": []}
{"input": "Although a carboxyl-terminal HSF transcriptional activation domain is critical for the activation of CUP1 transcription in response to both heat shock stress and glucose starvation, this region is dispensable for transient heat shock activation of at least two genes encoding members of the S. cerevisiae hsp70 family.", "output": {"entities": {"gene": [{"text": "HSF", "start": 29, "end": 32}, {"text": "CUP1", "start": 101, "end": 105}, {"text": "hsp70 family", "start": 305, "end": 317}]}}, "schema": []}
{"input": "We have recently detected high levels of CKB mRNA in HeLa cells and, in this study, have tested whether this may be due to the extremely low amounts of p53 protein present in HeLa cells.", "output": {"entities": {"gene": [{"text": "CKB mRNA", "start": 41, "end": 49}, {"text": "p53 protein", "start": 152, "end": 163}]}}, "schema": []}
{"input": "Distal lower motor neuron syndrome with high-titer serum IgM anti-GM1 antibodies: improvement following immunotherapy with monthly plasma exchange and intravenous cyclophosphamide.", "output": {"entities": {"gene": [{"text": "serum IgM anti-GM1 antibodies", "start": 51, "end": 80}]}}, "schema": []}
{"input": "Regulators responsible for the pervasive, nonsex-specific alternative pre-mRNA splicing characteristic of metazoans are almost entirely unknown or uncertain.", "output": {"entities": {}}, "schema": []}
{"input": "A normal systemic response was obtained after IF, indicating that rhG-CSF retains activity in the solid state.", "output": {"entities": {"gene": [{"text": "rhG-CSF", "start": 66, "end": 73}]}}, "schema": []}
{"input": "PAI-1 levels increased significantly in patients who received iohexol but not in those who received ioxaglate.", "output": {"entities": {"gene": [{"text": "PAI-1", "start": 0, "end": 5}]}}, "schema": []}
{"input": "Determination of potassium iodide in Polish edible salt", "output": {"entities": {}}, "schema": []}
{"input": "The recovery value of systolic pressure was higher than diastolic pressure and pulse pressure increased.", "output": {"entities": {}}, "schema": []}
{"input": "The importance of hepatitis C virus (HCV) infection as a cause of chronic liver disease has become clear with the introduction of serologic detection methods.", "output": {"entities": {}}, "schema": []}
{"input": "Human adenovirus type 41 contains two fibers.", "output": {"entities": {}}, "schema": []}
{"input": "Outflow obstruction of pancreatic juice, i. e., \" relative stenosis of the minor papilla, \" was considered to be present in the patients with type II papilla, and, therefore, the patients with type II papilla might suffer from acute pancreatitis resulting from poor drainage of pancreatic juice and excessive pressure in the dorsal duct.", "output": {"entities": {}}, "schema": []}
{"input": "Sequencing of the TP53 transcripts from exons 2 to 10, however, did not reveal mutations of the remaining allele in any of these tumors.", "output": {"entities": {"gene": [{"text": "TP53 transcripts", "start": 18, "end": 34}]}}, "schema": []}
{"input": "An unusual complication in an unsuitable patient.", "output": {"entities": {}}, "schema": []}
{"input": "In the ISO group, at pre-DEX, CBF increased from 86 +/-8 to 166 +/-19 mL. min-1. 100 g-1 in response to hypercapnia (PCO2 approximately 90 mmHg). (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {}}, "schema": []}
{"input": "All other ejaculate parameters (density, motility, swelling test, penetration test) remained unchanged, and there was only one post-therapeutic pregnancy.", "output": {"entities": {}}, "schema": []}
{"input": "KRN2391 and cromakalim produced a dose-dependent increase in aortic and coronary blood flow.", "output": {"entities": {}}, "schema": []}
{"input": "In H4IIE rat hepatoma cells, glucocorticoids, retinoic acid and cyclic AMP (cAMP) increase PEPCK gene transcription whereas insulin and phorbol esters have the opposite effect.", "output": {"entities": {"gene": [{"text": "PEPCK gene", "start": 91, "end": 101}, {"text": "insulin", "start": 124, "end": 131}]}}, "schema": []}
{"input": "Acta 572, 113-120].", "output": {"entities": {}}, "schema": []}
{"input": "Basal plasma AVP levels and AVP release after postural change were assessed, and plasma NPY levels were measured in the same samples.", "output": {"entities": {"gene": [{"text": "AVP", "start": 13, "end": 16}, {"text": "AVP", "start": 28, "end": 31}, {"text": "NPY", "start": 88, "end": 91}]}}, "schema": []}
{"input": "A stretch of 16 nucleotides just upstream of the IL-4RE contributed to IL-4 inducibility and formed nucleoprotein complexes with constitutive factors.", "output": {"entities": {"gene": [{"text": "IL-4RE", "start": 49, "end": 55}, {"text": "IL-4", "start": 71, "end": 75}]}}, "schema": []}
{"input": "Our previous study suggested that pertussis toxin (IAP)-sensitive GTP-binding protein (s) (G-protein) is involved in the process of differentiation by hormones/IBMX, accompanied by c-fos induction.", "output": {"entities": {"gene": [{"text": "pertussis toxin", "start": 34, "end": 49}, {"text": "IAP", "start": 51, "end": 54}, {"text": "GTP-binding protein (s)", "start": 66, "end": 89}, {"text": "G-protein", "start": 91, "end": 100}, {"text": "c-fos", "start": 181, "end": 186}]}}, "schema": []}
{"input": "ATX, like PC-1, was found to hydrolyze the type I phosphodiesterase substrate p-nitrophenyl thymidine-5'-monophosphate.", "output": {"entities": {"gene": [{"text": "ATX", "start": 0, "end": 3}, {"text": "PC-1", "start": 10, "end": 14}, {"text": "type I phosphodiesterase", "start": 43, "end": 67}]}}, "schema": []}
{"input": "The effect of site-specific mutations in the mouse platelet-derived growth factor (PDGF) beta-receptor on activation of the Na +/H + exchanger was examined in normal murine mammary gland epithelial (NMuMG) and Chinese hamster ovary (CHO) cells.", "output": {"entities": {"gene": [{"text": "mouse platelet-derived growth factor (PDGF) beta-receptor", "start": 45, "end": 102}, {"text": "Na +/H + exchanger", "start": 124, "end": 142}]}}, "schema": []}
{"input": "Sequence analysis revealed: 1) a kinase catalytic domain most characteristic of serine/threonine kinases but hybrid between members of the family of microtubule-associated protein kinase kinase kinases and the fibroblast growth factor receptor family; 2) two putative alpha-helical leucine zipper motifs separated by a 25-amino acid charged intermediate segment but lacking an NH2-terminal basic domain; and 3) COOH-terminal and NH2-terminal proline-rich domains suggestive of src homology 3 (SH3) domain binding regions.", "output": {"entities": {"gene": [{"text": "serine/threonine kinases", "start": 80, "end": 104}, {"text": "microtubule-associated protein kinase kinase kinases", "start": 149, "end": 201}, {"text": "fibroblast growth factor receptor family", "start": 210, "end": 250}, {"text": "src homology 3", "start": 477, "end": 491}, {"text": "SH3", "start": 493, "end": 496}]}}, "schema": []}
{"input": "Type 2 genomes containing this sequence presumably more closely reflect the structure of the infectious, replication-competent retrovirus ancestors of the HERV-K family than do type 1 genomes that lack the sequence.", "output": {"entities": {}}, "schema": []}
{"input": "However, when domain I and domain II were linked on the same plasmid, high levels of replication were observed.", "output": {"entities": {}}, "schema": []}
{"input": "Point mutations that suppressed the in vitro binding of NF-Y to the internal palindromic arm reduced the activity of the resident P4 promoter, while those preventing complex formation with USF did not, as determined by transient expression assays using the luciferase reporter gene.", "output": {"entities": {"gene": [{"text": "NF-Y", "start": 56, "end": 60}, {"text": "USF", "start": 189, "end": 192}, {"text": "luciferase", "start": 257, "end": 267}]}}, "schema": []}
{"input": "Surprisingly, nuclear forms of IE110 were found to move a cytoplasmic form of IE175 into nuclear punctate structures, and a cytoplasmic form of IE110 was able to retain nuclear forms of IE175 in cytoplasmic punctate structures.", "output": {"entities": {"gene": [{"text": "IE110", "start": 31, "end": 36}, {"text": "IE175", "start": 78, "end": 83}, {"text": "IE110", "start": 144, "end": 149}, {"text": "IE175", "start": 186, "end": 191}]}}, "schema": []}
{"input": "Transcription of the gene for ivanolysin O and expression of other genes of the virulence gene cluster in L. ivanovii were dependent on PrfA.", "output": {"entities": {"gene": [{"text": "ivanolysin O", "start": 30, "end": 42}, {"text": "virulence gene cluster in L. ivanovii", "start": 80, "end": 117}, {"text": "PrfA", "start": 136, "end": 140}]}}, "schema": []}
{"input": "Moreover, by complementation of the WA fyuA mutant by the cloned fyuA gene, yersiniabactin uptake and mouse virulence were restored.", "output": {"entities": {"gene": [{"text": "WA fyuA mutant", "start": 36, "end": 50}, {"text": "fyuA gene", "start": 65, "end": 74}]}}, "schema": []}
{"input": "The ICBF in the ischaemic cortex revealed a graded reduction from the ischaemic centre to the surrounding tissues.", "output": {"entities": {}}, "schema": []}
{"input": "The treatment of hydronephrosis in children", "output": {"entities": {}}, "schema": []}
{"input": "The inflation hub of the probe is recreated by modifying a standard USCI Tuohy-Borst Y adaptor and attaching this to the transected probe hypotube.", "output": {"entities": {}}, "schema": []}
{"input": "The other element bound RBP-J kappa with low affinity.", "output": {"entities": {"gene": [{"text": "RBP-J kappa", "start": 24, "end": 35}]}}, "schema": []}
{"input": "The basal promoter strength of constructs that contained deletions in the U5 region of the LTR was analyzed by chloramphenicol acetyltransferase (CAT) assays following transfection of HeLa cells or Jurkat T-cells in the presence or absence of viral transactivator tax protein.", "output": {"entities": {"gene": [{"text": "U5 region", "start": 74, "end": 83}, {"text": "chloramphenicol acetyltransferase", "start": 111, "end": 144}, {"text": "CAT", "start": 146, "end": 149}, {"text": "tax", "start": 264, "end": 267}]}}, "schema": []}
{"input": "In reviewing a number of the most intensely studied environmentally inducible promoters it becomes clear that the presence of two cis-acting elements are critical for promoter activity, one of which is the G-box (CCACGTGG).", "output": {"entities": {}}, "schema": []}
{"input": "Recently, a protein designated GF14 has been isolated that is associated with the GBF protein complex.", "output": {"entities": {"gene": [{"text": "GF14", "start": 31, "end": 35}, {"text": "GBF protein complex", "start": 82, "end": 101}]}}, "schema": []}
{"input": "New diagnostic strategies for lupus anticoagulants and antiphospholipid antibodies.", "output": {"entities": {}}, "schema": []}
{"input": "Propafenone is well tolerated in the majority of young patients.", "output": {"entities": {}}, "schema": []}
{"input": "Mutational analysis of yeast CEG1 demonstrated that four of the five conserved motifs are essential for capping enzyme function in vivo.", "output": {"entities": {"gene": [{"text": "yeast CEG1", "start": 23, "end": 33}, {"text": "capping enzyme", "start": 104, "end": 118}]}}, "schema": []}
{"input": "2 patients (11%) had significant morbidity 502 and 529 days respectively after transplantation.", "output": {"entities": {}}, "schema": []}
{"input": "Alternative splicing of the cytoplasmic tail appears to generate multiple PECAM-1 isoforms that may regulate phosphorylation, cytoskeletal association, and affinity modulation of the mature protein.", "output": {"entities": {"gene": [{"text": "PECAM-1 isoforms", "start": 74, "end": 90}]}}, "schema": []}
{"input": "Transfer also correlated inversely with gastric juice pH (r =-0. 619, P < 0. 02).", "output": {"entities": {}}, "schema": []}
{"input": "This technique has a sensitivity and a specificity of almost 100%, and is currently the best way to diagnose nodal involvement, apart from laparotomy.", "output": {"entities": {}}, "schema": []}
{"input": "The data show conclusively that phosphorylation of His-304 is not essential for any of the known functions of A. vinelandii NifL.", "output": {"entities": {"gene": [{"text": "A. vinelandii NifL", "start": 110, "end": 128}]}}, "schema": []}
{"input": "If this is present, such patients should be closely monitored, and any atypical lesions biopsied.", "output": {"entities": {}}, "schema": []}
{"input": "Cumulated maximum lod scores between FRDA and D9S5 and between FRDA and D9S15 are above 36 and 61, respectively, at a recombination fraction of 0, indicating that recombination events needed to orient the search of the gene are very difficult to identify and ascertain.", "output": {"entities": {"gene": [{"text": "FRDA", "start": 37, "end": 41}, {"text": "D9S5", "start": 46, "end": 50}, {"text": "FRDA", "start": 63, "end": 67}, {"text": "D9S15", "start": 72, "end": 77}]}}, "schema": []}
{"input": "A receptor-like protein kinase, OsPK10, has been cloned from rice (Oryza sativa).", "output": {"entities": {"gene": [{"text": "receptor-like protein kinase", "start": 2, "end": 30}, {"text": "OsPK10", "start": 32, "end": 38}]}}, "schema": []}
{"input": "A sequence representing about 50% of the expected complete sequence was obtained by translation of the two open reading frames present on a 1. 6 kb DNA genomic fragment.", "output": {"entities": {}}, "schema": []}
{"input": "Goodpasture' s-like syndrome and effect of extracorporeal membrane oxygenator support.", "output": {"entities": {}}, "schema": []}
{"input": "A cDNA clone pCZ1, with a 1. 1 kb insert, was isolated from a NaCl-adapted tobacco cell cDNA library that encodes an apparently full-length 29 kDa protein (251 amino acids) with a calculated pI of 5. 7.", "output": {"entities": {}}, "schema": []}
{"input": "METHODS--16 volunteered for spirometry with methacholine provocation test including a test for small airways function by volume of trapped gas (VTG).", "output": {"entities": {}}, "schema": []}
{"input": "Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK.", "output": {"entities": {"gene": [{"text": "CDK-activating kinase", "start": 16, "end": 37}, {"text": "RNA polymerase II", "start": 42, "end": 59}, {"text": "TFIIH", "start": 71, "end": 76}, {"text": "TFIIK", "start": 77, "end": 82}]}}, "schema": []}
{"input": "These same regions showed remarkable homology to two invertebrate proteins, CNC and skin-1, postulated to regulate embryonic development in Drosophila melanogaster and Caenorhabditis elegans, respectively.", "output": {"entities": {"gene": [{"text": "CNC", "start": 76, "end": 79}, {"text": "skin-1", "start": 84, "end": 90}]}}, "schema": []}
{"input": "DNA sequence analysis has confirmed that this mutation affects the C-terminal region of the alpha subunit, changing a leucine residue at position 290 to a histidine (rpoAL290H).", "output": {"entities": {"gene": [{"text": "rpoAL290H", "start": 166, "end": 175}]}}, "schema": []}
{"input": "CONCLUSIONS: These findings indicate a physical barrier of oesophageal surfactant which could offer some degree of protection against gastro-oesophageal reflux but one which is particularly prone to attack by bile.", "output": {"entities": {}}, "schema": []}
{"input": "Differential screening of mitochondrial cDNA libraries from male-fertile and cytoplasmic male-sterile sugar-beet reveals genome rearrangements at atp6 and atpA loci.", "output": {"entities": {"gene": [{"text": "atp6", "start": 146, "end": 150}, {"text": "atpA loci", "start": 155, "end": 164}]}}, "schema": []}
{"input": "The effects of social isolation on morphine-induced locomotor activity were compared in: (i) animals with an intact hypothalamo-pituitary-adrenal (HPA) axis; (ii) animals in which stress-induced corticosterone secretion was blocked by adrenalectomy.", "output": {"entities": {}}, "schema": []}
{"input": "Using this reporter gene system, we previously showed that EPO-induced activation of the c-fos promoter can be detected rapidly and sensitively as an elevation of cellular luciferase activity.", "output": {"entities": {"gene": [{"text": "EPO", "start": 59, "end": 62}, {"text": "c-fos promoter", "start": 89, "end": 103}, {"text": "cellular luciferase", "start": 163, "end": 182}]}}, "schema": []}
{"input": "I hypothesize that white gene expression from P [en] is repressed by the formation of a protein complex which is initiated at the engrailed PS sites and also requires interactions with flanking genomic DNA.", "output": {"entities": {"gene": [{"text": "white gene", "start": 19, "end": 29}, {"text": "P [en]", "start": 46, "end": 52}, {"text": "engrailed PS sites", "start": 130, "end": 148}]}}, "schema": []}
{"input": "SPP41 was cloned and sequenced and found to be essential. spp43 is allelic to the previously identified suppressor srn1, which encodes a negative regulator of gene expression.", "output": {"entities": {"gene": [{"text": "SPP41", "start": 0, "end": 5}, {"text": "spp43", "start": 58, "end": 63}, {"text": "suppressor srn1", "start": 104, "end": 119}]}}, "schema": []}
{"input": "Standard curve correlation coefficients of 0. 995 or greater were obtained during validation experiments and analysis of study samples.", "output": {"entities": {}}, "schema": []}
{"input": "To see if a pulse oximeter can monitor the fetus during labour we recruited 100 Caucasian women in normal uncomplicated labour.", "output": {"entities": {}}, "schema": []}
{"input": "There was no difference in plasma concentrations of PGI2 (figure 4) and TxA2 in patients with normal blood pressure, mild preeclampsia and hypotension, whereas in severe preeclampsia, the plasma concentration of PGI2 was significantly lower (p < 0. 001) and of TxA2 significantly higher (p < 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "A causal analysis of secondary variables showed that the formation of FB memories was primarily associated with the level of importance attached to the event and level of affective response to the news.", "output": {"entities": {}}, "schema": []}
{"input": "The IPL1 gene is required for high-fidelity chromosome segregation in the budding yeast Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "IPL1 gene", "start": 4, "end": 13}]}}, "schema": []}
{"input": "2.", "output": {"entities": {}}, "schema": []}
{"input": "The complete gene organization was obtained by combining the results of the sequence of these clones and those of the characterization of polymerase chain reaction-amplified genomic segments.", "output": {"entities": {}}, "schema": []}
{"input": "INO2, a regulatory gene in yeast phospholipid biosynthesis, affects nuclear segregation and bud pattern formation.", "output": {"entities": {"gene": [{"text": "INO2", "start": 0, "end": 4}]}}, "schema": []}
{"input": "The pentafluorobenzyl derivative of clonidine yields an intense ion fragment at m/z 354, and the lower limit of detection is 0. 025 ng/ml for a 1-ml plasma sample.", "output": {"entities": {}}, "schema": []}
{"input": "Mammalian ABPs and SHBGs bind sex steroids with high affinity, but some binding properties differ among species.", "output": {"entities": {"gene": [{"text": "Mammalian ABPs", "start": 0, "end": 14}, {"text": "SHBGs", "start": 19, "end": 24}]}}, "schema": []}
{"input": "Src homology (SH) domain dependent protein-protein interactions are important to tyrosine kinase receptor signal transduction.", "output": {"entities": {"gene": [{"text": "Src homology", "start": 0, "end": 12}, {"text": "SH", "start": 14, "end": 16}, {"text": "tyrosine kinase receptor", "start": 81, "end": 105}]}}, "schema": []}
{"input": "Sample treatment was optimized in order to achieve a complete extraction of labetalol diastereoisomers and to avoid racemization during extraction.", "output": {"entities": {}}, "schema": []}
{"input": "Under resting conditions, activity levels of cardiac vagal and sympathetic outflows are not related across young, healthy human subjects and peripheral interaction is not manifest between the autonomic divisions.", "output": {"entities": {}}, "schema": []}
{"input": "Both proprioceptive and electroreceptive units showed a progression of receptive fields from anterior to posterior body in the rostral to caudal direction along the length of DGR.", "output": {"entities": {}}, "schema": []}
{"input": "In control patients, baseline images presented Type I in 25, Type II in 7, and the Type III & IV in 0, and the Type after loading was the same as the Type at baseline.", "output": {"entities": {}}, "schema": []}
{"input": "A more complete analysis of dose response, time and mode of Ga administration (preinjury or postinjury), and availability of Ga across the blood-brain barrier is needed to further evaluate the efficacy of this compound.", "output": {"entities": {}}, "schema": []}
{"input": "The presence of regulatory sequences for the binding of transcription factors such as NF-kappa B and AP-2, whose activation is associated with the immediate response of the cell to an injury, may be an indication of the important role which HO-1 may play in defense mechanisms against tissue injury.", "output": {"entities": {"gene": [{"text": "NF-kappa B", "start": 86, "end": 96}, {"text": "AP-2", "start": 101, "end": 105}, {"text": "HO-1", "start": 241, "end": 245}]}}, "schema": []}
{"input": "Granisetron, but not saline, abolished vomiting and nausea when given as intervention after this combined emetic regimen.", "output": {"entities": {}}, "schema": []}
{"input": "The femoroarterial coronary sinus difference in lactate turned negative, and pH, PCO2 and potassium differences increased in group 2 during pacing.", "output": {"entities": {}}, "schema": []}
{"input": "This was obtained with the thermal neutron fluency 2. 0 x 10 (10) n/cm2.", "output": {"entities": {}}, "schema": []}
{"input": "Endotoxemia induced by gram-negative bacteria leads to endotoxic shock pathogenetically stemming from the integral component of the bacterial wall--lipid A.", "output": {"entities": {}}, "schema": []}
{"input": "The study made to define the ability of lipid A monoclonal antibodies to correct hemodynamic disturbances due to endotoxemia in dog experiments showed the efficacy of the antibodies administration.", "output": {"entities": {"gene": [{"text": "lipid A monoclonal antibodies", "start": 40, "end": 69}]}}, "schema": []}
{"input": "A randomised, controlled trial was undertaken in 40 patients with active Crohn' s disease to evaluate clinical and nutritional outcomes after an amino acid based diet containing 3% fat was given by a feeding tube compared with a peptide based diet containing 33% fat.", "output": {"entities": {}}, "schema": []}
{"input": "The sequenced genomic region thus accounts for essentially all of the longest known transcript (4. 5 kb), although the precise ends of this transcript have not been defined.", "output": {"entities": {}}, "schema": []}
{"input": "The pexB upstream region contained 245 nucleotides within which sequences approximating the consensus for cyclic AMP receptor protein and integration host factor binding sites were discernible.", "output": {"entities": {"gene": [{"text": "pexB upstream region", "start": 4, "end": 24}, {"text": "cyclic AMP receptor protein", "start": 106, "end": 133}, {"text": "integration host factor", "start": 138, "end": 161}]}}, "schema": []}
{"input": "The fepA-entD and fes-entF operons in the enterobactin synthesis and transport system are divergently transcribed from overlapping promoters, and both are inhibited by the Fur repressor protein under iron-replete conditions.", "output": {"entities": {"gene": [{"text": "fepA", "start": 4, "end": 8}, {"text": "entD", "start": 9, "end": 13}, {"text": "fes", "start": 18, "end": 21}, {"text": "entF", "start": 22, "end": 26}, {"text": "Fur repressor protein", "start": 172, "end": 193}]}}, "schema": []}
{"input": "Sequence analysis of a 6. 3-kbp genomic EcoRI-fragment of Alcaligenes eutrophus, which was recently identified by using a dihydrolipoamide dehydrogenase-specific DNA probe (A.", "output": {"entities": {"gene": [{"text": "EcoRI", "start": 40, "end": 45}, {"text": "dihydrolipoamide dehydrogenase", "start": 122, "end": 152}]}}, "schema": []}
{"input": "Using a previously published two-frequency (AC excitation) three-electrode method, the admittance locus plot (ALP) in the low-frequency region (< 1000 Hz) has been shown to be very well approximated by a straight line and can be described with frequency-independent parameters; phase angle alpha pi/2, conductance at extrapolated zero frequency G0 = 1/R0, and ion relaxation time tau.", "output": {"entities": {}}, "schema": []}
{"input": "Intraoperative measurement of activated partial thromboplastin time and prothrombin time with a new compact monitor.", "output": {"entities": {"gene": [{"text": "thromboplastin", "start": 48, "end": 62}, {"text": "prothrombin", "start": 72, "end": 83}]}}, "schema": []}
{"input": "In addition, we sought to test the hypothesis that, when equal volumes are administered intrathecally, significant differences exist in the potential to three commonly used anesthetic solutions to induce sensory impairment.", "output": {"entities": {}}, "schema": []}
{"input": "In an in vitro study, 10/0 nylon was found to require a significantly lower laser energy density to produce suture lysis following a single shot than either 10/0 Dacron or 10/0 prolene.", "output": {"entities": {}}, "schema": []}
{"input": "The proteins encoded downstream of rpoN are known to negatively regulate sigma 54 activity.", "output": {"entities": {"gene": [{"text": "rpoN", "start": 35, "end": 39}, {"text": "sigma 54", "start": 73, "end": 81}]}}, "schema": []}
{"input": "We report here that microinjection of an anti-CBP antiserum into fibroblasts can inhibit transcription from a cAMP responsive promoter.", "output": {"entities": {"gene": [{"text": "anti-CBP antiserum", "start": 41, "end": 59}]}}, "schema": []}
{"input": "These results demonstrate that a class of proline-rich activator proteins and RNA polymerase II possess a common structural and functional component which can interact with the same target in the general transcription machinery.", "output": {"entities": {"gene": [{"text": "RNA polymerase II", "start": 78, "end": 95}]}}, "schema": []}
{"input": "Cloning of higher plant omega-3 fatty acid desaturases.", "output": {"entities": {"gene": [{"text": "higher plant omega-3 fatty acid desaturases", "start": 11, "end": 54}]}}, "schema": []}
{"input": "65, 3829-3838, 1991), a truncated form of the IE polypeptide lacking IE amino acid residues 1-322 (and, therefore lacks the deduced transcriptional activation domain), fails to transactivate the EHV-1 tk promoter, but retains the ability to down-regulate the EHV-1 IE promoter.", "output": {"entities": {"gene": [{"text": "IE polypeptide", "start": 46, "end": 60}, {"text": "IE amino acid residues 1-322", "start": 69, "end": 97}, {"text": "EHV-1 tk promoter", "start": 195, "end": 212}, {"text": "EHV-1 IE promoter", "start": 259, "end": 276}]}}, "schema": []}
{"input": "CONCLUSION: Human preterm birth is associated with significantly lower progesterone/17 beta-estradiol ratios than those of women with preterm labor delivered at term.", "output": {"entities": {}}, "schema": []}
{"input": "In conclusion, the disposition of venlafaxine and O-desmethylvenlafaxine is markedly altered in renal disease; therefore dosage adjustment is warranted for patients with creatinine clearance values below 30 ml/min.", "output": {"entities": {}}, "schema": []}
{"input": "The availability of sequence from multiple species has permitted us to determine that the UBE site has close similarity to motifs that bind members of the NF-1 family of transcription factors.", "output": {"entities": {"gene": [{"text": "NF-1 family of transcription factors", "start": 155, "end": 191}]}}, "schema": []}
{"input": "The incidence of HSV-2 positive subjects (HSV-2/HSV-1 antibody ratio > or = 1) was low in the Jewish Israeli population, compared to other demographic areas.", "output": {"entities": {"gene": [{"text": "HSV-2/HSV-1 antibody", "start": 42, "end": 62}]}}, "schema": []}
{"input": "The mechanism whereby zeta PKC regulates NF-kappa B most probably involves the activation of a putative I kappa B kinase of molecular mass approximately 50 kDa, which phosphorylates and inactivates I kappa B.", "output": {"entities": {"gene": [{"text": "zeta PKC", "start": 22, "end": 30}, {"text": "NF-kappa B", "start": 41, "end": 51}, {"text": "I kappa B kinase", "start": 104, "end": 120}, {"text": "I kappa B", "start": 198, "end": 207}]}}, "schema": []}
{"input": "Stable expression of truncated inositol 1, 4, 5-trisphosphate receptor subunits in 3T3 fibroblasts.", "output": {"entities": {"gene": [{"text": "truncated inositol 1, 4, 5-trisphosphate receptor subunits", "start": 21, "end": 79}]}}, "schema": []}
{"input": "We report the identification and characterization of myr 4 (myosin from rat), the first mammalian myosin I that is not closely related to brush border myosin I.", "output": {"entities": {"gene": [{"text": "myr 4", "start": 53, "end": 58}, {"text": "myosin from rat", "start": 60, "end": 75}, {"text": "mammalian myosin I", "start": 88, "end": 106}, {"text": "myosin I", "start": 151, "end": 159}]}}, "schema": []}
{"input": "M., and D.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, computer analysis suggests that sequences similar to the A stem element are present within the three AAV promoter regions.", "output": {"entities": {"gene": [{"text": "AAV promoter", "start": 114, "end": 126}]}}, "schema": []}
{"input": "At least some of the difference in stability of the two kinds of complexes was due to the fact that the dissociation rate of the A stem substrate from the protein-DNA complexes was approximately fourfold faster than that of the complete TR.", "output": {"entities": {"gene": [{"text": "TR", "start": 237, "end": 239}]}}, "schema": []}
{"input": "Processing of the NS3'-5B polyprotein was complex and occurred rapidly.", "output": {"entities": {"gene": [{"text": "NS3'", "start": 18, "end": 22}, {"text": "5B", "start": 23, "end": 25}]}}, "schema": []}
{"input": "However, each promoter activated by IEP86 was synergistically affected by the addition of IEP72.", "output": {"entities": {"gene": [{"text": "IEP86", "start": 36, "end": 41}, {"text": "IEP72", "start": 90, "end": 95}]}}, "schema": []}
{"input": "32Pi labeling or isoelectric focusing analysis of eIF-2 alpha from conditional casein kinase II mutants indicated that phosphorylation of eIF-2 alpha is abolished or dephosphorylated forms of eIF-2 alpha are detected when these strains are grown at the restrictive growth conditions.", "output": {"entities": {"gene": [{"text": "eIF-2 alpha", "start": 50, "end": 61}, {"text": "casein kinase II mutants", "start": 79, "end": 103}, {"text": "eIF-2 alpha", "start": 138, "end": 149}, {"text": "eIF-2 alpha", "start": 192, "end": 203}]}}, "schema": []}
{"input": "The R2 region within the class I enhancer acts as a negative element in Ad12-transformed cells and exhibits a stronger binding activity than is observed in nontumorigenic Ad5-transformed cells, which are not reduced in class I expression.", "output": {"entities": {}}, "schema": []}
{"input": "PURPOSE: To evaluate the kinetics of erythropoietin (EPO) production and address the pathogenesis of anemia of prematurity, we measured EPO levels in infants during the first year of life.", "output": {"entities": {"gene": [{"text": "erythropoietin", "start": 37, "end": 51}, {"text": "EPO", "start": 53, "end": 56}, {"text": "EPO", "start": 136, "end": 139}]}}, "schema": []}
{"input": "The nerve growth factor beta gene (NGFB) belongs to a conserved syntenic group on human chromosome 1 and mouse Chromosome 3.", "output": {"entities": {"gene": [{"text": "nerve growth factor beta gene", "start": 4, "end": 33}, {"text": "NGFB", "start": 35, "end": 39}]}}, "schema": []}
{"input": "Furthermore, an upstream element, collagen element I (-370/-344), which shares homology with the LAP binding cis-element of the albumin promoter (9 of 13 bp) is described.", "output": {"entities": {"gene": [{"text": "collagen element I (-370/-344)", "start": 34, "end": 64}, {"text": "LAP", "start": 97, "end": 100}, {"text": "albumin promoter", "start": 128, "end": 144}]}}, "schema": []}
{"input": "Number and size of silver-stained nucleoli (Ag-NOR clusters) in canine seminomas: correlation with histological features and tumour behaviour.", "output": {"entities": {}}, "schema": []}
{"input": "We speculate that mast cell degranulation may be involved in the pathogenesis of necrobiosis by altering fibroblast enzyme activity and/or producing prolonged inflammatory reactions.", "output": {"entities": {}}, "schema": []}
{"input": "Molecular cloning of a cysteine synthase cDNA from Citrullus vulgaris (watermelon) by genetic complementation in an Escherichia coli Cys-auxotroph.", "output": {"entities": {"gene": [{"text": "cysteine synthase cDNA", "start": 23, "end": 45}]}}, "schema": []}
{"input": "In earlier studies we identified several regulatory elements that control transcriptional activation and aerobic repression of one of these genes, COX5b.", "output": {"entities": {"gene": [{"text": "COX5b", "start": 147, "end": 152}]}}, "schema": []}
{"input": "Although elevated serum levels of antibodies to the nicotinic acetylcholine receptor (nAChR) have been reported in neuroleptic treated patients with tardive dyskinesia, such antibodies have not been determined in comparable nondyskinetic patients.", "output": {"entities": {"gene": [{"text": "nicotinic acetylcholine receptor", "start": 52, "end": 84}, {"text": "nAChR", "start": 86, "end": 91}]}}, "schema": []}
{"input": "The tumor suppressor and transcriptional factor p53 is a phosphorylated protein.", "output": {"entities": {"gene": [{"text": "p53", "start": 48, "end": 51}]}}, "schema": []}
{"input": "This DNA containing promoter activity has been sequenced in its entirety and found to contain multiple putative regulatory sites.", "output": {"entities": {}}, "schema": []}
{"input": "However, Southern blot and karyotype analyses did not reveal any significant changes in copy number or gross rearrangements of the p53 gene in any of the p53-cell lines.", "output": {"entities": {"gene": [{"text": "p53 gene", "start": 131, "end": 139}, {"text": "p53-", "start": 154, "end": 158}]}}, "schema": []}
{"input": "HupI showed strong identity to rubredoxin and rubredoxin-like proteins from many other bacteria.", "output": {"entities": {"gene": [{"text": "HupI", "start": 0, "end": 4}, {"text": "rubredoxin", "start": 31, "end": 41}, {"text": "rubredoxin-like proteins", "start": 46, "end": 70}]}}, "schema": []}
{"input": "The PCr resynthesis rate (P < 0. 01) and the effective maximal rate of mitochondrial ATP synthesis (P < 0. 05) also improved.", "output": {"entities": {}}, "schema": []}
{"input": "An examination was performed in 15 patients who had developed pronounced osteomalacia following gastric resection.", "output": {"entities": {}}, "schema": []}
{"input": "However, regional MVO2 increased to about the same extent in the CFX (from 6. 0 +/-0. 7 to 12. 4 +/-0. 9 ml O2. min-1 times 100 g-1) and the LAD region (from 7. 0 +/-0. 6 to 14. 5 +/-1. 3 ml O2. min-1 times 100 g-1).", "output": {"entities": {}}, "schema": []}
{"input": "IGF I and insulin receptors are homologous proteins that function in distinct physiological pathways.", "output": {"entities": {"gene": [{"text": "IGF I", "start": 0, "end": 5}, {"text": "insulin receptors", "start": 10, "end": 27}]}}, "schema": []}
{"input": "Immunodepression was combined with the increase of glucocorticoid activity of adrenal cortex, while no significant changes in thyroid hormones were registered.", "output": {"entities": {}}, "schema": []}
{"input": "Aberrant protein phosphorylation at tyrosine is responsible for the growth-inhibitory action of pp60v-src expressed in the yeast Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "pp60v-src", "start": 96, "end": 105}]}}, "schema": []}
{"input": "Acute pancreatitis: a multisystem disease.", "output": {"entities": {}}, "schema": []}
{"input": "Alginate biosynthesis is controlled by a complex regulatory mechanism.", "output": {"entities": {}}, "schema": []}
{"input": "The sequence upstream of the rhlA promoter contains two inverted repeats which define putative binding sites for the RhlR regulator.", "output": {"entities": {"gene": [{"text": "rhlA promoter", "start": 29, "end": 42}, {"text": "RhlR regulator", "start": 117, "end": 131}]}}, "schema": []}
{"input": "We have examined by in vitro footprinting a region located downstream of the human immunodeficiency virus, type 1 (HIV-1) promoter found to be hypersensitive to DNase I digestion in vivo.", "output": {"entities": {"gene": [{"text": "DNase I", "start": 161, "end": 168}]}}, "schema": []}
{"input": "The relative abundance of each alternatively spliced mRNA was determined by reverse transcription-polymerase chain reaction in various human tissues and cell lines.", "output": {"entities": {}}, "schema": []}
{"input": "The retention index of 201Tl SPECT is a useful indicator of metastatic potential, thereby facilitating the prediction of prognosis, and provides insight into the relationship between 201Tl uptake and malignancy.", "output": {"entities": {}}, "schema": []}
{"input": "The central globular domain is highly similar to those regions from other H1 molecules, and the carboxyl-terminal domain contains a repeating hexapeptide motif, variants of which are conserved among H1 molecules.", "output": {"entities": {"gene": [{"text": "H1 molecules", "start": 74, "end": 86}, {"text": "H1 molecules", "start": 199, "end": 211}]}}, "schema": []}
{"input": "The location and approximate length of the intron are conserved in both the tomato and Arabidopsis genes, with the intron separating the' nose' region (encoded by exon 1) from the central globular domain (exon 2).", "output": {"entities": {}}, "schema": []}
{"input": "The topology and chain folding of the beta subunits in the artifactual beta 60 capsid are similar to the native alpha 3 beta 60 enzyme.", "output": {"entities": {"gene": [{"text": "native alpha 3 beta 60 enzyme", "start": 105, "end": 134}]}}, "schema": []}
{"input": "A constitutive mutant form with a single substitution (V88A) in the amino-terminal (response regulator) region was used.", "output": {"entities": {}}, "schema": []}
{"input": "Comparisons of the four operon control regions studied indicate that the NarL heptamers are arranged with diverse orientations and spacing.", "output": {"entities": {"gene": [{"text": "NarL heptamers", "start": 73, "end": 87}]}}, "schema": []}
{"input": "Direct binding and competition assays using 30-mer oligonucleotide probes representing the individual CBF1 binding sites indicated that CBF1 bound less efficiently to the CD23 promoter and the EBV LMP-1 promoter sites than to the Cp site.", "output": {"entities": {"gene": [{"text": "CBF1 binding sites", "start": 102, "end": 120}, {"text": "CBF1", "start": 136, "end": 140}, {"text": "CD23 promoter", "start": 171, "end": 184}, {"text": "EBV LMP-1 promoter sites", "start": 193, "end": 217}, {"text": "Cp site", "start": 230, "end": 237}]}}, "schema": []}
{"input": "We have found a satisfactory reproducibility in vitro (T1: 1. 9%; T2: 6. 2%), while the reproducibility was less satisfactory in vivo (T1: 16. 4%; T2: 13. 4%).", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSION: Sonographic angiography has a possible role in the detection of small nodules in patients with CRF.", "output": {"entities": {}}, "schema": []}
{"input": "Each expressed domain, as well as FKBP-33 itself, possesses peptidyl-prolyl cis-trans isomerase activity, though with much lower specific activities than FKBP-12.", "output": {"entities": {"gene": [{"text": "FKBP-33", "start": 34, "end": 41}, {"text": "peptidyl-prolyl cis-trans isomerase", "start": 60, "end": 95}, {"text": "FKBP-12", "start": 154, "end": 161}]}}, "schema": []}
{"input": "The first 85 nt upstream of the transcription initiation site of the mouse desmin gene, which contain an E box (E1), the binding site of the helix-loop-helix myogenic regulators, are sufficient to confer low level muscle-specific expression.", "output": {"entities": {"gene": [{"text": "mouse desmin gene", "start": 69, "end": 86}, {"text": "helix-loop-helix myogenic regulators", "start": 141, "end": 177}]}}, "schema": []}
{"input": "The acfD gene encompasses 254 nt that are predicted to encode an 88-amino-acid (aa) protein.", "output": {"entities": {"gene": [{"text": "acfD gene", "start": 4, "end": 13}]}}, "schema": []}
{"input": "We find that beta II PKC phosphorylates nuclear envelope lamin B at 10-20 times the rate of alpha PKC, whereas both kinases phosphorylate soluble lamin B at similar rates.", "output": {"entities": {"gene": [{"text": "beta II PKC", "start": 13, "end": 24}, {"text": "nuclear envelope lamin B", "start": 40, "end": 64}, {"text": "alpha PKC", "start": 92, "end": 101}, {"text": "soluble lamin B", "start": 138, "end": 153}]}}, "schema": []}
{"input": "Regulation of parathyroid hormone-related protein (PTHrP) gene expression.", "output": {"entities": {"gene": [{"text": "parathyroid hormone-related protein", "start": 14, "end": 49}, {"text": "PTHrP", "start": 51, "end": 56}]}}, "schema": []}
{"input": "We conclude that c-Abl activates c-myc transcription indirectly with no requirement for DNA binding by c-Abl.", "output": {"entities": {"gene": [{"text": "c-Abl", "start": 17, "end": 22}, {"text": "c-myc", "start": 33, "end": 38}, {"text": "c-Abl", "start": 103, "end": 108}]}}, "schema": []}
{"input": "Long-latency: locked units responded to shocks with little jitter and long latency (4-11 ms).", "output": {"entities": {}}, "schema": []}
{"input": "The highly conserved ninth heptad, which is involved in heterodimerization, appears to participate in the receptor-inhibitor interaction, suggesting that the inhibitor is a related member of the receptor gene family.", "output": {"entities": {}}, "schema": []}
{"input": "Here we show that for expression of snRNA genes in maize, a monocotyledonous plant, the USE and TATA elements are essential, but not sufficient, for transcription.", "output": {"entities": {}}, "schema": []}
{"input": "Extensive DNA rearrangement occurs during the development of the somatic macronucleus from the germ line micronucleus in ciliated protozoans.", "output": {"entities": {}}, "schema": []}
{"input": "An in vitro binding site selection procedure was used to determine DNA sequences preferentially bound by wild-type HLF and chimeric E2A-HLF proteins isolated from various t (17; 19)-bearing leukemias.", "output": {"entities": {"gene": [{"text": "wild-type HLF", "start": 105, "end": 118}, {"text": "E2A", "start": 132, "end": 135}, {"text": "HLF", "start": 136, "end": 139}]}}, "schema": []}
{"input": "The Oct-2 glutamine-rich and proline-rich activation domains can synergize with each other or duplicates of themselves to activate transcription.", "output": {"entities": {"gene": [{"text": "Oct-2", "start": 4, "end": 9}]}}, "schema": []}
{"input": "Taken together, our data suggest that Dbf8p plays an essential role in chromosome segregation.", "output": {"entities": {"gene": [{"text": "Dbf8p", "start": 38, "end": 43}]}}, "schema": []}
{"input": "Ariga, Biochem.", "output": {"entities": {}}, "schema": []}
{"input": "The diagnostic significance of creatine phosphokinase antibodies in the cardiac muscle in non-coronarogenic myocardial diseases", "output": {"entities": {"gene": [{"text": "creatine phosphokinase", "start": 31, "end": 53}]}}, "schema": []}
{"input": "According to the results of assays obtained with the use of assay systems ORTHO ELISA and ABBOTT HCV EIA (USA), the detection rate of anti-HCV-C100-3 among primary blood donors in Moscow was 1. 37% and was not different from that among HBsAg carriers (1. 8%) and among donors with anti-HCV-C100-3 in the blood (1. 6%) (p < 0. 01).", "output": {"entities": {"gene": [{"text": "anti-HCV-C100-3", "start": 134, "end": 149}, {"text": "HBsAg", "start": 236, "end": 241}, {"text": "anti-HCV-C100-3", "start": 281, "end": 296}]}}, "schema": []}
{"input": "We examined the hypothesis that the coronary vasomotor responses to etomidate (ETO), propofol (PRO), and sodium thiopental (STP) are mediated through contrasting effects on the resting nitric oxide (NO)-dependent vasodilator tone that opposes adrenergic vasoconstrictor activity in the intact dog.", "output": {"entities": {}}, "schema": []}
{"input": "These alternative splice variants were detected in RNA isolated from several sources, including primary leptomeningeal tissue and an established line of leptomeningeal cells (LMC).", "output": {"entities": {}}, "schema": []}
{"input": "Roux-en-Y gastroenterostomy severely disturbs emptying of the gallbladder.", "output": {"entities": {}}, "schema": []}
{"input": "Surface-coil experiments on phantoms and on human calf muscles in vivo are presented.", "output": {"entities": {}}, "schema": []}
{"input": "Large interpatient variation in peak PCZ plasma levels (91-3215 ng/ml) was seen, with the plasma half-life (t1/2 alpha) being approximately 57 min in patients given 135-180 mg/m2 PCZ.", "output": {"entities": {}}, "schema": []}
{"input": "The maximal effect was seen at 100 ng/ml EGF, with a time lag of about 5 h.", "output": {"entities": {"gene": [{"text": "EGF", "start": 41, "end": 44}]}}, "schema": []}
{"input": "KAR1 encodes an essential component of the yeast spindle pole body (SPB) that is required for karyogamy and SPB duplication.", "output": {"entities": {"gene": [{"text": "KAR1", "start": 0, "end": 4}]}}, "schema": []}
{"input": "CDC31 is required for SPB duplication and encodes a calmodulin-like protein that is most closely related to caltractin/centrin, a protein associated with the Chlamydomonas basal body.", "output": {"entities": {"gene": [{"text": "CDC31", "start": 0, "end": 5}, {"text": "calmodulin-like protein", "start": 52, "end": 75}, {"text": "caltractin", "start": 108, "end": 118}, {"text": "centrin", "start": 119, "end": 126}]}}, "schema": []}
{"input": "During transcript elongation, the sizes of the DNA footprint and the single-stranded transcription bubble vary markedly among transcription complexes halted at different template positions.", "output": {"entities": {}}, "schema": []}
{"input": "All our patients had polyps, 23 (54%) had asthma, 12 (27%) had aspirin sensitivity, 20 (65%) had eosinophilia, and 9 (69%) had increased total IgE levels.", "output": {"entities": {"gene": [{"text": "IgE", "start": 143, "end": 146}]}}, "schema": []}
{"input": "A new generation of information retrieval tools for biologists: the example of the ExPASy WWW server.", "output": {"entities": {}}, "schema": []}
{"input": "The partial ORF was found to be identical to the C terminus of HrpJ2.", "output": {"entities": {"gene": [{"text": "HrpJ2", "start": 63, "end": 68}]}}, "schema": []}
{"input": "The partial ORF was found to be identical to the C terminus of HrpJ2.", "output": {"entities": {"gene": [{"text": "HrpJ2", "start": 63, "end": 68}]}}, "schema": []}
{"input": "Rapid detection of this mutation is achieved by restriction digestion of PCR-amplified genomic DNA; a mismatch primer combined with the point mutation creates a Tru9I restriction site.", "output": {"entities": {"gene": [{"text": "Tru9I restriction site", "start": 161, "end": 183}]}}, "schema": []}
{"input": "Wild type and mutant Epo cDNAs were transiently expressed at high levels in COS1 and COS7 cells.", "output": {"entities": {"gene": [{"text": "Wild type and mutant Epo cDNAs", "start": 0, "end": 30}]}}, "schema": []}
{"input": "OBJECTIVE--To assess the risk of hepatitis A in international travelers and to recommend preventive measures.", "output": {"entities": {}}, "schema": []}
{"input": "The bactericidal effect of disinfectants against biofilm cells was found to be considerably enhanced by increasing the concentrations of the disinfectants.", "output": {"entities": {}}, "schema": []}
{"input": "Expression of ME31B cDNA in S. pombe suppresses the ste13 mutation.", "output": {"entities": {"gene": [{"text": "ME31B cDNA", "start": 14, "end": 24}, {"text": "ste13", "start": 52, "end": 57}]}}, "schema": []}
{"input": "Use of Medi-Jector EZ dermojet for anesthesia in minor surgery", "output": {"entities": {}}, "schema": []}
{"input": "The immune response of past-infection of cytomegalovirus in the patients of RTID is rather remarkable.", "output": {"entities": {}}, "schema": []}
{"input": "Acupuncture effect on deep receptors was not limited to one point but within a certain area, namely distant effect existed.", "output": {"entities": {}}, "schema": []}
{"input": "Reduced NK activity correlates with active disease in HIV-patients with multidrug-resistant pulmonary tuberculosis.", "output": {"entities": {}}, "schema": []}
{"input": "Smoking history and awake oxygen saturation (SaO2) was recorded in all of them.", "output": {"entities": {}}, "schema": []}
{"input": "(LH P < 0. 05, LH/FSH P < 0. 01).", "output": {"entities": {"gene": [{"text": "LH", "start": 1, "end": 3}, {"text": "LH", "start": 15, "end": 17}, {"text": "FSH", "start": 18, "end": 21}]}}, "schema": []}
{"input": "The relative R-and L-brain weights were found to be inversely related to the relative R-L brain weight only in the RH female cats with R-L brain weight smaller than zero (testosterone in males, estrogen in females).", "output": {"entities": {}}, "schema": []}
{"input": "This mode of ternary complex formation is in contrast to the one seen in the promoter of the c-fos protooncogene, where formation of the ternary complex is dependent on the prior assembly of the serum response factor-DNA binary complex.", "output": {"entities": {"gene": [{"text": "c-fos protooncogene", "start": 93, "end": 112}, {"text": "serum response factor-DNA binary complex", "start": 195, "end": 235}]}}, "schema": []}
{"input": "Vaccinia virus-expressed, purified full-length HPV-16 and BPV-1 E2 proteins bound a consensus E2 site with high specific affinities (Kd = approximately 10 (-9) M) and stimulated in vitro transcription up to six-to eightfold.", "output": {"entities": {"gene": [{"text": "full-length HPV-16 and BPV-1 E2 proteins", "start": 35, "end": 75}, {"text": "E2 site", "start": 94, "end": 101}]}}, "schema": []}
{"input": "This alternatively spliced transcript contained an open reading frame extending from the upstream J alpha 11-2 region to 82 nucleotides downstream of the beginning of the TCR C alpha region, and potentially encoded a 36 amino acid polypeptide.", "output": {"entities": {"gene": [{"text": "TCR C alpha region", "start": 171, "end": 189}]}}, "schema": []}
{"input": "In HeLa x fibroblast cell hybrids its expression correlates with tumorigenicity.", "output": {"entities": {}}, "schema": []}
{"input": "Demographic characteristics and risk factor data for 76, 672 clients were studied to characterize the distribution of infection with human immunodeficiency virus (HIV) and the use of counseling and testing facilities in Houston, Tex.", "output": {"entities": {}}, "schema": []}
{"input": "Results indicate that KNM-LU 335 differs from both human and chimpanzee M1s in relative distances (measured in three dimensions) between crown fissure termini.", "output": {"entities": {}}, "schema": []}
{"input": "We describe 49 cases with papillary tumor < 1 cm.", "output": {"entities": {}}, "schema": []}
{"input": "Comparison with the bovine gene showed that the 5'-flanking region of the hATP1 gene has an unconserved guanine-cytosine (GC) rich region, including several binding motifs of transcriptional factors, such as Sp1, AP-2, and GCF.", "output": {"entities": {"gene": [{"text": "hATP1 gene", "start": 74, "end": 84}, {"text": "Sp1", "start": 208, "end": 211}, {"text": "AP-2", "start": 213, "end": 217}, {"text": "GCF", "start": 223, "end": 226}]}}, "schema": []}
{"input": "Structure, promoter analysis and chromosomal assignment of the human APEX gene.", "output": {"entities": {"gene": [{"text": "human APEX gene", "start": 63, "end": 78}]}}, "schema": []}
{"input": "The polyubiquitin gene was transcribed throughout the Volvox life cycle with peaks in the 1. 6-kb mRNA levels during pre-cleavage, cleavage, and post-inversion.", "output": {"entities": {"gene": [{"text": "polyubiquitin gene", "start": 4, "end": 22}]}}, "schema": []}
{"input": "Thus, in stress-induced arrhythmic disease as well as in ischemic heart disease, the main pathogenetic links are outside the heart, but they differ from those observed in ischemia.", "output": {"entities": {}}, "schema": []}
{"input": "Here, we present genetic evidence in Saccharomyces cerevisiae for a functional interaction between the DEAH protein Prp16, and the U6 and U2 spliceosomal snRNAs.", "output": {"entities": {"gene": [{"text": "DEAH protein Prp16", "start": 103, "end": 121}, {"text": "U6", "start": 131, "end": 133}, {"text": "U2 spliceosomal snRNAs", "start": 138, "end": 160}]}}, "schema": []}
{"input": "The consensus gene order deduced by combining data from both crosses is D2Mit1-(Dbh, Notch1)-(Col5a1, Rxra)-Spna2-Ab l-(Ak1, Fpgs)-(Grp78, Pbx3)-(Epb7. 2, Hc, Gsn)-Acra.", "output": {"entities": {"gene": [{"text": "D2Mit1", "start": 72, "end": 78}, {"text": "Dbh", "start": 80, "end": 83}, {"text": "Notch1", "start": 85, "end": 91}, {"text": "Col5a1", "start": 94, "end": 100}, {"text": "Rxra", "start": 102, "end": 106}, {"text": "Spna2", "start": 108, "end": 113}, {"text": "Ab l", "start": 114, "end": 118}, {"text": "Ak1", "start": 120, "end": 123}, {"text": "Fpgs", "start": 125, "end": 129}, {"text": "Grp78", "start": 132, "end": 137}, {"text": "Pbx3", "start": 139, "end": 143}, {"text": "Epb7. 2, Hc, Gsn", "start": 146, "end": 162}, {"text": "Acra", "start": 164, "end": 168}]}}, "schema": []}
{"input": "The high level of transformation-associated deletions in the human YACs was reduced over 10-fold when the host was a recombination-deficient strain deleted for the RAD52 gene.", "output": {"entities": {"gene": [{"text": "RAD52 gene", "start": 164, "end": 174}]}}, "schema": []}
{"input": "In addition, the megabase region surrounding the dagA locus was mapped.", "output": {"entities": {"gene": [{"text": "dagA locus", "start": 49, "end": 59}]}}, "schema": []}
{"input": "These mutants had deletions of the extreme amino-terminal residues as far as amino acid residue 30.", "output": {"entities": {}}, "schema": []}
{"input": "SECONDARY OUTCOME MEASURE--Double-blind caffeine-withdrawal evaluation.", "output": {"entities": {}}, "schema": []}
{"input": "Elimination of natural antibodies in discordant xenografts", "output": {"entities": {}}, "schema": []}
{"input": "An 8-bp sequence (ATTTCAAA) within the protected region shares significant homology with promoter sequences required for ethylene responsiveness from the tomato fruit-ripening E4 gene.", "output": {"entities": {"gene": [{"text": "E4 gene", "start": 176, "end": 183}]}}, "schema": []}
{"input": "We present evidence that DNA polymerase delta of Saccharomyces cerevisiae, an enzyme that is essential for viability and chromosomal replication, is also required for base excision repair of exogenous DNA methylation damage.", "output": {"entities": {"gene": [{"text": "DNA polymerase delta of Saccharomyces cerevisiae", "start": 25, "end": 73}]}}, "schema": []}
{"input": "We have identified two Marek' s Disease Virus (MDV) genes within the EcoRI-B fragment of MDV-GA genomic DNA.", "output": {"entities": {"gene": [{"text": "EcoRI-B fragment", "start": 69, "end": 85}]}}, "schema": []}
{"input": "Cowpox virus contains two copies of an early gene encoding a soluble secreted form of the type II TNF receptor.", "output": {"entities": {"gene": [{"text": "early gene", "start": 39, "end": 49}, {"text": "type II TNF receptor", "start": 90, "end": 110}]}}, "schema": []}
{"input": "Mutagenesis of each NRF-1 motif in the ALAS promoter gave substantially lowered levels of chloramphenicol acetyltransferase expression, whereas mutagenesis of both NRF-1 motifs resulted in the almost complete loss of expression.", "output": {"entities": {"gene": [{"text": "NRF-1 motif", "start": 20, "end": 31}, {"text": "ALAS promoter", "start": 39, "end": 52}, {"text": "chloramphenicol acetyltransferase", "start": 90, "end": 123}, {"text": "NRF-1 motifs", "start": 164, "end": 176}]}}, "schema": []}
{"input": "DNase I footprinting analysis indicated that DREF binds to the 24-bp DRE region of the DNA polymerase alpha gene in which 8-bp palindromic sequences are centered.", "output": {"entities": {"gene": [{"text": "DNase I", "start": 0, "end": 7}, {"text": "DREF", "start": 45, "end": 49}, {"text": "DNA polymerase alpha gene", "start": 87, "end": 112}]}}, "schema": []}
{"input": "Novel 8-base pair sequence (Drosophila DNA replication-related element) and specific binding factor involved in the expression of Drosophila genes for DNA polymerase alpha and proliferating cell nuclear antigen.", "output": {"entities": {"gene": [{"text": "DNA polymerase alpha", "start": 151, "end": 171}, {"text": "proliferating cell nuclear antigen", "start": 176, "end": 210}]}}, "schema": []}
{"input": "Most, however, would tell the spouse the full truth about both diagnosis and prognosis.", "output": {"entities": {}}, "schema": []}
{"input": "Metabolism of calcium and vitamin D3 in patients with acute tubulointerstitial nephritis: a study of 41 patients with nephropathia epidemica.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, this study demonstrates that reduced inotropy with timolol helped uniform local contraction as estimated by the increased LONG/CIRC ratio, a transition that could improve contraction efficacy.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of moderate hypercapnia on hypothermia induced by cold He-O2 in rats.", "output": {"entities": {}}, "schema": []}
{"input": "We recommend that ovarian stimulation is done only if there is a valid indication after proper assessment of the ovaries, and that women who have had ovarian stimulation are followed for longer than at present.", "output": {"entities": {}}, "schema": []}
{"input": "A23187 did not induce any modifications of the endolymphatic potential, the ampullar direct current or the frequency of the evoked afferent spikes.", "output": {"entities": {}}, "schema": []}
{"input": "Activation of the aboral ectoderm-specific Spec2a gene in blastula-stage sea urchin embryos requires an upstream regulatory region that is part of a repetitive sequence element (RSR) associated with all Spec1/Spec2 genes.", "output": {"entities": {"gene": [{"text": "ectoderm-specific Spec2a gene", "start": 25, "end": 54}, {"text": "Spec1", "start": 203, "end": 208}, {"text": "Spec2", "start": 209, "end": 214}]}}, "schema": []}
{"input": "A transcript of about 2 kb is expected for each PPO.", "output": {"entities": {"gene": [{"text": "PPO", "start": 48, "end": 51}]}}, "schema": []}
{"input": "Mutations in a region located 15 to 30 bp downstream from the major transcription start site that shows good homology to a sequence in the first exon of c-fos implicated as a negative regulatory element resulted in a significant increase in basal gene expression but did not affect regulation.", "output": {"entities": {"gene": [{"text": "c-fos", "start": 153, "end": 158}]}}, "schema": []}
{"input": "Salazopyrine desensitization", "output": {"entities": {}}, "schema": []}
{"input": "During exercise, the Pes-Ves relation was shifted toward the left and the slope [end-systolic elastance (Ees)] increased from 7. 7 +/-2. 8 to 12. 7 +/-4. 2 (SD) mmHg/ml (P < 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "We show that HRI and dsRNA-PK phosphorylate yeast eIF-2 alpha in vitro and in vivo and functionally substitute for GCN2 protein to stimulate GCN4 translation in yeast.", "output": {"entities": {"gene": [{"text": "HRI", "start": 13, "end": 16}, {"text": "dsRNA-PK", "start": 21, "end": 29}, {"text": "yeast eIF-2 alpha", "start": 44, "end": 61}, {"text": "GCN2 protein", "start": 115, "end": 127}, {"text": "GCN4", "start": 141, "end": 145}]}}, "schema": []}
{"input": "Double-staining confirmed that there were separate populations of CD68-positive macrophages and XIIIa-positive dendrocytes.", "output": {"entities": {"gene": [{"text": "CD68", "start": 66, "end": 70}, {"text": "XIIIa", "start": 96, "end": 101}]}}, "schema": []}
{"input": "Interestingly, in the adult, transgene expression patterns within the cerebellum in two lines appeared to mark distinct anterior-posterior compartments.", "output": {"entities": {}}, "schema": []}
{"input": "The concentrations of plasma ACTH and cortisol increased by 40% and 60% after MPTP treatment, respectively.", "output": {"entities": {"gene": [{"text": "ACTH", "start": 29, "end": 33}]}}, "schema": []}
{"input": "Instead, the results support the idea that Pc group products provide stable memory or imprinting of boundaries which are initially specified by gap and pair-rule regulators.", "output": {"entities": {"gene": [{"text": "Pc group products", "start": 43, "end": 60}]}}, "schema": []}
{"input": "To investigate the regulation of expression of the human mdr1 gene, the response of the mdr1 promoter to signals involved in cell proliferation was examined.", "output": {"entities": {"gene": [{"text": "human mdr1 gene", "start": 51, "end": 66}, {"text": "mdr1 promoter", "start": 88, "end": 101}]}}, "schema": []}
{"input": "Tobacco mosaic virus-infected tobacco (Nicotiana tabacum var.", "output": {"entities": {}}, "schema": []}
{"input": "Through a stretch of 56 amino acids, constituting the MADS domain, the two proteins are identical except for two conservative amino acid substitutions.", "output": {"entities": {"gene": [{"text": "MADS domain", "start": 54, "end": 65}]}}, "schema": []}
{"input": "Isolation and characterization of SRF accessory proteins.", "output": {"entities": {"gene": [{"text": "SRF accessory proteins", "start": 34, "end": 56}]}}, "schema": []}
{"input": "These data suggest that: (a) proSRIF cleavage is initiated in the TGN, and (b) this reaction requires an acidic pH which is facilitated by a Golgi-associated vacuolar-type ATPase.", "output": {"entities": {"gene": [{"text": "proSRIF", "start": 29, "end": 36}, {"text": "Golgi-associated vacuolar-type ATPase", "start": 141, "end": 178}]}}, "schema": []}
{"input": "Clinical aspects of early increase in serum gamma-glutamyl transferase in cerebral infarction.", "output": {"entities": {"gene": [{"text": "gamma-glutamyl transferase", "start": 44, "end": 70}]}}, "schema": []}
{"input": "In the 3' flanking region of the 27 kDa zein gene, several AATAAA-like sequences and a sequence resembling the mammalian GT-rich sequence are present around the polyadenylation sites.", "output": {"entities": {"gene": [{"text": "27 kDa zein gene", "start": 33, "end": 49}]}}, "schema": []}
{"input": "The indoor radon concentration in the summer (1990) period ranged between 8 and 81 Bq m-3, while in the winter (1989-1990) it ranged between 20 and 143 Bq m-3 for the first year of measurements or between 8 and 92 Bq m-3 in the summer (1991) period and between 12 and 119 Bq m-3 in the winter (1990-1991) for the second year of measurements.", "output": {"entities": {}}, "schema": []}
{"input": "DtxR is an iron-dependent sequence-specific DNA-binding protein that binds to the tox operator, an inverted-repeat nucleotide sequence located upstream from the diphtheria toxin gene.", "output": {"entities": {"gene": [{"text": "DtxR", "start": 0, "end": 4}, {"text": "tox operator", "start": 82, "end": 94}, {"text": "diphtheria toxin gene", "start": 161, "end": 182}]}}, "schema": []}
{"input": "Vasopressin (AVP), the antidiuretic hormone, is a cyclic nonapeptide that acts through binding to G protein-coupled specific membrane receptors pharmacologically divided into three subtypes (V1a, V1b, and V2) linked to distinct second messengers.", "output": {"entities": {"gene": [{"text": "Vasopressin", "start": 0, "end": 11}, {"text": "AVP", "start": 13, "end": 16}, {"text": "G protein-coupled specific membrane receptors", "start": 98, "end": 143}, {"text": "V1a", "start": 191, "end": 194}, {"text": "V1b", "start": 196, "end": 199}, {"text": "V2", "start": 205, "end": 207}]}}, "schema": []}
{"input": "These results confirmed that cleavage of the leader peptide is the last step in nisin maturation and is necessary to generate a biologically active peptide.", "output": {"entities": {"gene": [{"text": "nisin", "start": 80, "end": 85}]}}, "schema": []}
{"input": "When the promoter region was linked with a heterologous reporter gene, we found that the promoter region is inducible by both interferons (interferon-alpha and-gamma) and interferon regulatory factor 1.", "output": {"entities": {"gene": [{"text": "interferons", "start": 126, "end": 137}, {"text": "interferon-alpha and-gamma", "start": 139, "end": 165}, {"text": "interferon regulatory factor 1", "start": 171, "end": 201}]}}, "schema": []}
{"input": "Anti-B. burgdorferi, anti-B. turicatae and anti-B. parkeri antibodies, tested by the indirect immunofluorescent assay (IFA), were detected in 10. 8, 16. 1 and 8. 2% of the serum samples tested, and confirmed by IFA-ABS in 1. 3, 1. 3 and 1. 0%, respectively.", "output": {"entities": {"gene": [{"text": "Anti-B. burgdorferi", "start": 0, "end": 19}, {"text": "anti-B. turicatae", "start": 21, "end": 38}, {"text": "anti-B. parkeri antibodies", "start": 43, "end": 69}]}}, "schema": []}
{"input": "The approach derives from a recently described strategy for making recombinants from five overlapping EBV cosmid-cloned DNAs (B.", "output": {"entities": {}}, "schema": []}
{"input": "Evaluation of desmopressin for dental extractions in patients with hemostatic disorders.", "output": {"entities": {}}, "schema": []}
{"input": "Comparative analysis with an antiandrogen niftolid and synthetic GnRH was carried out in 22 normal subjects, 14 patients with primary and 20 ones with secondary hypogonadism, and in 5 patients with clinical signs of gonadal insufficiency and obscure diagnosis in order to elucidate the pituitary gonadotropin reserves.", "output": {"entities": {"gene": [{"text": "synthetic GnRH", "start": 55, "end": 69}, {"text": "pituitary gonadotropin", "start": 286, "end": 308}]}}, "schema": []}
{"input": "The cis-acting regulatory properties of an 872 bp promoter fragment of a B. napus oleosin gene were examined by analysis of beta-glucuronidase (GUS) expression in transgenic tobacco plants containing an oleosin promoter-GUS transcriptional fusion.", "output": {"entities": {"gene": [{"text": "oleosin gene", "start": 82, "end": 94}, {"text": "beta-glucuronidase", "start": 124, "end": 142}, {"text": "GUS", "start": 144, "end": 147}, {"text": "oleosin promoter", "start": 203, "end": 219}, {"text": "GUS", "start": 220, "end": 223}]}}, "schema": []}
{"input": "This indicates that the mechanism by which CX blocks rapid degradation of tubulin mRNA in vivo is not simply by preventing its translation and suggests the involvement of an altered trans-factor.", "output": {"entities": {"gene": [{"text": "tubulin mRNA", "start": 74, "end": 86}]}}, "schema": []}
{"input": "Increasing the extracellular calcium concentration enhanced detrusor contractility in a dose-dependent manner in both control and obstructed bladders.", "output": {"entities": {}}, "schema": []}
{"input": "Structural organization of the gene encoding the human lipocalin tear prealbumin and synthesis of the recombinant protein in Escherichia coli.", "output": {"entities": {"gene": [{"text": "human lipocalin tear prealbumin", "start": 49, "end": 80}]}}, "schema": []}
{"input": "The sequence has a 1092-bp open reading frame encoding a protein of 364 amino acids.", "output": {"entities": {}}, "schema": []}
{"input": "The gene organization of CRSV RNA-1 is similar to those of red clover necrotic mosaic (RCNMV) and sweet clover necrotic mosaic (SCNMV) dianthoviruses with the exception that CRSV RNA-1 contains the additional 3'-terminal ORF.", "output": {"entities": {"gene": [{"text": "CRSV RNA-1", "start": 25, "end": 35}, {"text": "CRSV RNA-1", "start": 174, "end": 184}]}}, "schema": []}
{"input": "We have previously shown that LBP-1 represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA box.", "output": {"entities": {"gene": [{"text": "LBP-1", "start": 30, "end": 35}, {"text": "TFIID", "start": 95, "end": 100}]}}, "schema": []}
{"input": "These results illustrate an important role for La in RNA production by demonstrating its ability to clear the termination sites of class III templates, thereby promoting efficient use of transcription complexes by pol III.", "output": {"entities": {"gene": [{"text": "La", "start": 47, "end": 49}, {"text": "pol III", "start": 214, "end": 221}]}}, "schema": []}
{"input": "The films were analyzed using a scanning helium-neon laser densitometer with a small aperture of 5-10 microns.", "output": {"entities": {}}, "schema": []}
{"input": "The GafChromic method has proven to be an accurate and rapid method of analysis and could be easily incorporated into a quality assurance program.", "output": {"entities": {}}, "schema": []}
{"input": "Viral genomic RNA for these reactions was obtained directly from fecal specimens of infected infant rats.", "output": {"entities": {}}, "schema": []}
{"input": "GATA-1 mRNA was present in equivalent levels in both erythroid cell lines, but at a low level in FDC-P1 cells.", "output": {"entities": {"gene": [{"text": "GATA-1 mRNA", "start": 0, "end": 11}]}}, "schema": []}
{"input": "Tumor necrosis factor-alpha (TNF alpha) is one of several autocrine/paracrine factors known to exert potent inhibitory effects on bone.", "output": {"entities": {"gene": [{"text": "Tumor necrosis factor-alpha", "start": 0, "end": 27}, {"text": "TNF alpha", "start": 29, "end": 38}]}}, "schema": []}
{"input": "We have investigated the role of cellular p21ras protein in insulin and insulin-like growth factor-I (IGF-I) signaling pathways.", "output": {"entities": {"gene": [{"text": "cellular p21ras protein", "start": 33, "end": 56}, {"text": "insulin", "start": 60, "end": 67}, {"text": "insulin-like growth factor-I", "start": 72, "end": 100}, {"text": "IGF-I", "start": 102, "end": 107}]}}, "schema": []}
{"input": "The lack of the C2 domain of the Ca (2 +)-dependent PKCs and the presence of a unique NH2-terminal sequence with a potential signal peptide and a transmembrane domain suggest that PKC mu is a novel member of the subgroup of atypical PKCs.", "output": {"entities": {"gene": [{"text": "C2", "start": 16, "end": 18}, {"text": "Ca (2 +)-dependent PKCs", "start": 33, "end": 56}, {"text": "PKC mu", "start": 180, "end": 186}, {"text": "PKCs", "start": 233, "end": 237}]}}, "schema": []}
{"input": "Moreover, we observed that the function of T3R-RXR heterodimers on response elements composed of two half-sites in a directly repeated orientation spaced by 4 nucleotides is determined in major parts by the 5'-flanking sequence of the upstream half-site.", "output": {"entities": {"gene": [{"text": "T3R", "start": 43, "end": 46}, {"text": "RXR", "start": 47, "end": 50}]}}, "schema": []}
{"input": "However, three Hm1 mutants that were moderately deficient in stimulating PI turnover displayed normal sequestration, suggesting distinct mechanisms.", "output": {"entities": {"gene": [{"text": "Hm1 mutants", "start": 15, "end": 26}]}}, "schema": []}
{"input": "Furthermore, in vitro decay reaction mixtures supplemented with the 20-nt sense RNA transcript resulted in stabilization of R2 message.", "output": {"entities": {"gene": [{"text": "R2 message", "start": 124, "end": 134}]}}, "schema": []}
{"input": "Deletion analyses of the pCD41 ORF-A and the use of promoter constructs further mapped an internal functional promoter within the pCD41 sequence that can direct the synthesis of the trans-activating protein.", "output": {"entities": {"gene": [{"text": "pCD41 ORF-A", "start": 25, "end": 36}, {"text": "pCD41 sequence", "start": 130, "end": 144}]}}, "schema": []}
{"input": "The inferred amino acid sequence of the cyanobacterial HemB protein indicates a significant difference in the metal cofactor requirement from the higher-plant enzymes, which was confirmed by overexpression and biochemical analysis.", "output": {"entities": {"gene": [{"text": "cyanobacterial HemB protein", "start": 40, "end": 67}]}}, "schema": []}
{"input": "METHODS AND RESULTS: In 25 open-chest, anesthetized dogs, progressive circumflex artery stenosis led to a concordant decrease of circumflex artery resting and hyperemic flow, coronary flow reserve, and inverse angiographic mean transit time Tmicro-1 (P <. 01).", "output": {"entities": {}}, "schema": []}
{"input": "However, a correlation was observed between SF levels of IL-8 with those of lactate, LDH, beta 2-microglobulin and glucose.", "output": {"entities": {"gene": [{"text": "IL-8", "start": 57, "end": 61}, {"text": "LDH", "start": 85, "end": 88}, {"text": "beta 2-microglobulin", "start": 90, "end": 110}]}}, "schema": []}
{"input": "Sodium-taurocholate-induced acute necrotizing pancreatitis does not affect jejunal oxygenation in pigs.", "output": {"entities": {}}, "schema": []}
{"input": "Although inactive in cells under normal conditions, the CHOP gene is markedly induced by a variety of cellular stresses, including nutrient deprivation and metabolic perturbations.", "output": {"entities": {"gene": [{"text": "CHOP gene", "start": 56, "end": 65}]}}, "schema": []}
{"input": "The ipiO genes code for two almost identical 152-aa proteins which do not have any homology with sequences present in data libraries.", "output": {"entities": {"gene": [{"text": "ipiO genes", "start": 4, "end": 14}]}}, "schema": []}
{"input": "Sterol analysis of the disrupted mutant demonstrated the accumulation of ignosterol, indicating a loss of Erg24p activity.", "output": {"entities": {"gene": [{"text": "Erg24p", "start": 106, "end": 112}]}}, "schema": []}
{"input": "In these experiments we begin to study the potential functions of the alpha 7 cytoplasmic domain by analyzing homologies between the rat and human sequences, by immunologic studies using an anti-cytoplasmic domain antiserum, and by identifying two alternate forms.", "output": {"entities": {"gene": [{"text": "alpha 7 cytoplasmic domain", "start": 70, "end": 96}]}}, "schema": []}
{"input": "The alpha 7A form RNA contains an additional 113 nucleotides compared to the B form, and a common coding region in the A and B form RNAs is used in alternate reading frames.", "output": {"entities": {}}, "schema": []}
{"input": "In order to evaluate the function of the hypothalamic-pituitary-thyroid (HPT)-axis in unipolar depression, the authors measured basal 0800h plasma levels of free thyroxine (FT4), free triiodothyronine (FT3), and thyroid stimulating hormone (TSH) by means of the new, ultrasensitive assays (TSH-IRMA) in 69 healthy controls, 62 minor, 101 simple major, and 57 melancholic depressed subjects.", "output": {"entities": {"gene": [{"text": "thyroid stimulating hormone", "start": 212, "end": 239}, {"text": "TSH", "start": 241, "end": 244}]}}, "schema": []}
{"input": "CRS function in a 5' LTR-linked gene expression assay correlates with the ability of both p60CRS and p40CRS to interact with 5' LTR RNA in vitro.", "output": {"entities": {"gene": [{"text": "CRS", "start": 0, "end": 3}, {"text": "p60CRS", "start": 90, "end": 96}, {"text": "p40CRS", "start": 101, "end": 107}]}}, "schema": []}
{"input": "Serial levels of troponin T and the activity of CK-MB were measured 6, 12, 24 and 48 h after aortic unclamping.", "output": {"entities": {"gene": [{"text": "troponin T", "start": 17, "end": 27}, {"text": "CK-MB", "start": 48, "end": 53}]}}, "schema": []}
{"input": "Regionalization of drug delivery is a potential method to avoid this problem.", "output": {"entities": {}}, "schema": []}
{"input": "The epidemic occurred in a group of 26 community members (23 men and 3 women, mean age, 28. 9--3 years) living and working together, who underwent acute and convalescent serologic tests for Mycoplasma pneumoniae, Legionella pneumophila, cytomegalovirus, adenovirus, Coxiella burnetii, and Chlamydia pneumoniae.", "output": {"entities": {}}, "schema": []}
{"input": "MEK itself is activated via serine phosphorylation by upstream activator kinases, including c-raf, mos and MEK kinase.", "output": {"entities": {"gene": [{"text": "MEK", "start": 0, "end": 3}, {"text": "upstream activator kinases", "start": 54, "end": 80}, {"text": "c-raf", "start": 92, "end": 97}, {"text": "mos", "start": 99, "end": 102}, {"text": "MEK kinase", "start": 107, "end": 117}]}}, "schema": []}
{"input": "Members of SVA are also present in the complement C2 gene located about 20 kilobases upstream of RP1 in the HLA and in the cytochrome CYP1A1 gene.", "output": {"entities": {"gene": [{"text": "SVA", "start": 11, "end": 14}, {"text": "complement C2 gene", "start": 39, "end": 57}, {"text": "RP1", "start": 97, "end": 100}, {"text": "HLA", "start": 108, "end": 111}, {"text": "cytochrome CYP1A1 gene", "start": 123, "end": 145}]}}, "schema": []}
{"input": "European Community Huntington' s Disease Collaborative Study Group.", "output": {"entities": {}}, "schema": []}
{"input": "The c-myc and skeletal alpha-actin gene promoters contain YY1 binding sites thought to act either as positive or negative cis-acting elements.", "output": {"entities": {"gene": [{"text": "c-myc", "start": 4, "end": 9}, {"text": "skeletal alpha-actin gene promoters", "start": 14, "end": 49}, {"text": "YY1 binding sites", "start": 58, "end": 75}]}}, "schema": []}
{"input": "MSSP-1 produced in E. coli as a fusion protein with GST specifically interacted with single-stranded TCTTAT (plus myc (H-P) 21) and ACT-ATT (in minus myc (H-P) 21), the consensus of which can be referred to as A/TCTA/TA/TT.", "output": {"entities": {"gene": [{"text": "MSSP-1", "start": 0, "end": 6}, {"text": "GST", "start": 52, "end": 55}, {"text": "myc", "start": 114, "end": 117}, {"text": "myc", "start": 150, "end": 153}]}}, "schema": []}
{"input": "Within 12 hours after MR tomography the patients were surgically explored, biopsied and if necessary orchiectomised.", "output": {"entities": {}}, "schema": []}
{"input": "Varieties of envious experience.", "output": {"entities": {}}, "schema": []}
{"input": "The results show that both the amino and carboxy termini of the NS1 protein molecule and the cysteines at residues 337 and 340 are essential for tubule formation.", "output": {"entities": {"gene": [{"text": "NS1 protein molecule", "start": 64, "end": 84}]}}, "schema": []}
{"input": "The 3' UTR has several stable hairpins that are flanked by single-stranded (A/U) UGC sequences.", "output": {"entities": {}}, "schema": []}
{"input": "Moreover, the major site of transcriptional initiation, which was localized by primer extension 250 bp upstream of the 5' end of the Ets-1 cDNA clone, was shown to be identical in normal cells and tumors carrying a provirus in the Tpl-1 locus.", "output": {"entities": {"gene": [{"text": "Ets-1 cDNA clone", "start": 133, "end": 149}, {"text": "Tpl-1 locus", "start": 231, "end": 242}]}}, "schema": []}
{"input": "Specifically, by oligonucleotide-directed site-specific mutagenesis, we demonstrate that of 10 cysteine residues in the ORF4 polypeptide, only C-421 and C-426 are essential for transactivator function and suggest that these cysteine residues may participate in critical protein-protein interactions rather than protein-nucleic acid interactions to mediate ORF4 inducibility.", "output": {"entities": {}}, "schema": []}
{"input": "To search for genes that interact with the SLK1-SLT2 pathway, a synthetic lethal suppression screen was carried out.", "output": {"entities": {"gene": [{"text": "SLK1", "start": 43, "end": 47}, {"text": "SLT2", "start": 48, "end": 52}]}}, "schema": []}
{"input": "Genetic and phenotypic analysis indicates that NHP6A and NHP6B function downstream of SLT2.", "output": {"entities": {"gene": [{"text": "NHP6A", "start": 47, "end": 52}, {"text": "NHP6B", "start": 57, "end": 62}, {"text": "SLT2", "start": 86, "end": 90}]}}, "schema": []}
{"input": "In this report, we present two lines of evidence that all ribosomes which synthesize GCN4 have previously translated uORF1, resumed scanning, and reinitiated at the GCN4 start site.", "output": {"entities": {"gene": [{"text": "GCN4", "start": 85, "end": 89}, {"text": "GCN4", "start": 165, "end": 169}]}}, "schema": []}
{"input": "Identical components of yeast transcription factor IIIB are required and sufficient for transcription of TATA box-containing and TATA-less genes.", "output": {"entities": {"gene": [{"text": "transcription factor IIIB", "start": 30, "end": 55}]}}, "schema": []}
{"input": "Concordantly, it was shown that the dnHLH protein Id1 inhibits differentiation of muscle and myeloid cells in vitro.", "output": {"entities": {"gene": [{"text": "dnHLH protein Id1", "start": 36, "end": 53}]}}, "schema": []}
{"input": "RNP1, a new ribonucleoprotein gene of the yeast Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "RNP1", "start": 0, "end": 4}]}}, "schema": []}
{"input": "Crohn' s disease in prolonged remission: should one augment protein-calorie intake as compared to healthy subjects?] The aim of our two year prospective study was to evaluate whether adult Crohn' s disease patients in prolonged remission (CDAI < 150), in order to maintain their body weight as close as possible to the ideal one, need a protein-calorie intake higher than the predicted one and that of healthy controls.", "output": {"entities": {}}, "schema": []}
{"input": "To achieve complete dissection of the anterior vitreous, we remove even a clear lens during the first surgical intervention in selected cases.", "output": {"entities": {}}, "schema": []}
{"input": "Restoration of opponens function with transplantation of free composites dorsal pedal skin flap containing m. extensor hallucis brevis", "output": {"entities": {}}, "schema": []}
{"input": "Neither ethanol regimen impaired spontaneous alternation, but the 4 g ethanol. kg-1 x day-1 regimen increased the percent completed trials.", "output": {"entities": {}}, "schema": []}
{"input": "The mean (+/-sd) intra-vesicular pressure (IVP) and maximal urethral closure pressures (MUCP) were 10. 3 (+/-1. 7) and 129. 8 (+/-19. 6) cmH2O, respectively, and the ratio between MUCP and IVP was 13. 2 (+/-2. 5).", "output": {"entities": {}}, "schema": []}
{"input": "Several highly conserved regions were identified at the near N terminus, middle and C terminus.", "output": {"entities": {}}, "schema": []}
{"input": "Thioredoxin (TR) is a small ubiquitous dithiol-reductase enzyme first identified in bacteria and plants.", "output": {"entities": {"gene": [{"text": "Thioredoxin", "start": 0, "end": 11}, {"text": "TR", "start": 13, "end": 15}, {"text": "dithiol-reductase enzyme", "start": 39, "end": 63}]}}, "schema": []}
{"input": "The mutation within the asgB480 allele was identified as an A-to-G transition that results in a threonine-to-alanine substitution in the predicted protein product.", "output": {"entities": {"gene": [{"text": "asgB480 allele", "start": 24, "end": 38}]}}, "schema": []}
{"input": "The cysteine-rich region of raf-1 kinase contains zinc, translocates to liposomes, and is adjacent to a segment that binds GTP-ras.", "output": {"entities": {"gene": [{"text": "raf-1 kinase", "start": 28, "end": 40}, {"text": "GTP-ras", "start": 123, "end": 130}]}}, "schema": []}
{"input": "Kinetic coupling and requirement for ATP hydrolysis.", "output": {"entities": {}}, "schema": []}
{"input": "ATP by itself also reduced polypeptide binding to Ssb1/2p to a level that was intermediate between that observed for the Ssa Hsp70 proteins tested and BiP and DnaK.", "output": {"entities": {"gene": [{"text": "Ssb1/2p", "start": 50, "end": 57}, {"text": "Ssa Hsp70 proteins", "start": 121, "end": 139}, {"text": "BiP", "start": 151, "end": 154}, {"text": "DnaK", "start": 159, "end": 163}]}}, "schema": []}
{"input": "Digestion of NF-IL6 with endoprotease Asp-N produced a domain smaller than the TCD (NF-IL6 bZIP domains (NFBD) (272-345)), a domain identified either in the absence or the presence of DNA.", "output": {"entities": {"gene": [{"text": "NF-IL6", "start": 13, "end": 19}, {"text": "endoprotease Asp-N", "start": 25, "end": 43}, {"text": "TCD", "start": 79, "end": 82}, {"text": "NF-IL6 bZIP domains", "start": 84, "end": 103}, {"text": "NFBD", "start": 105, "end": 109}]}}, "schema": []}
{"input": "Signaling by tyrosine kinases involves direct associations between proteins with Src homology 2 (SH2) domains and sites of tyrosine phosphorylation.", "output": {"entities": {"gene": [{"text": "tyrosine kinases", "start": 13, "end": 29}, {"text": "Src homology 2", "start": 81, "end": 95}, {"text": "SH2", "start": 97, "end": 100}]}}, "schema": []}
{"input": "Rather, complete skipping of exon V and subsequent joining of exon IV to exon VI caused a shift in the open reading frame, which remodeled GPHe (P2) with an elongated new hydrophobic sequence for membrane anchoring.", "output": {"entities": {"gene": [{"text": "GPHe (P2)", "start": 139, "end": 148}]}}, "schema": []}
{"input": "The responses of the \" stress hormones \" cortisol, 11-deoxycortisol, ACTH, vasopressin (AVP), and corticotropin releasing factor (CRF) were studied in 6 normal males in response to acute cortisol deficiency induced by the 11-beta-hydroxylase inhibitor, metyrapone.", "output": {"entities": {"gene": [{"text": "ACTH", "start": 69, "end": 73}, {"text": "vasopressin", "start": 75, "end": 86}, {"text": "AVP", "start": 88, "end": 91}, {"text": "corticotropin releasing factor", "start": 98, "end": 128}, {"text": "CRF", "start": 130, "end": 133}, {"text": "11-beta-hydroxylase", "start": 222, "end": 241}]}}, "schema": []}
{"input": "Thus our observations establish a functional link between the PKC and retinoid pathways, which are generally considered to have antagonistic activities on differentiation processes.", "output": {"entities": {"gene": [{"text": "PKC", "start": 62, "end": 65}]}}, "schema": []}
{"input": "The colony-stimulating factors (CSFs) principally involved in the production of neutrophils and monocytes are granulocyte CSF, granulocyte-macrophage CSF, macrophage CSF, and interleukin 3 (sometimes called multi-CSF).", "output": {"entities": {"gene": [{"text": "colony-stimulating factors", "start": 4, "end": 30}, {"text": "CSFs", "start": 32, "end": 36}, {"text": "granulocyte CSF", "start": 110, "end": 125}, {"text": "granulocyte-macrophage CSF", "start": 127, "end": 153}, {"text": "macrophage CSF", "start": 155, "end": 169}, {"text": "interleukin 3", "start": 175, "end": 188}, {"text": "multi-CSF", "start": 207, "end": 216}]}}, "schema": []}
{"input": "The degree of lung destruction, reflected by interstitial hemorrhage was assessed by measuring hemoglobin content in the fluid of the lavaged lungs.", "output": {"entities": {"gene": [{"text": "hemoglobin", "start": 95, "end": 105}]}}, "schema": []}
{"input": "Expression plasmids harboring full-length or kinase domain of PKC alpha and PKC delta (PKC alpha K and PKC delta K) were constructed.", "output": {"entities": {"gene": [{"text": "PKC alpha", "start": 62, "end": 71}, {"text": "PKC delta", "start": 76, "end": 85}, {"text": "PKC alpha K", "start": 87, "end": 98}, {"text": "PKC delta K", "start": 103, "end": 114}]}}, "schema": []}
{"input": "These results indicate that both PKC alpha (calcium dependent) and PKC delta (calcium independent) may mediate the transcription of TPA-inducible genes through both AP-1 and non-AP-1 sequences.", "output": {"entities": {"gene": [{"text": "PKC alpha", "start": 33, "end": 42}, {"text": "PKC delta", "start": 67, "end": 76}, {"text": "AP-1", "start": 165, "end": 169}, {"text": "AP-1", "start": 178, "end": 182}]}}, "schema": []}
{"input": "With a cutoff level for TSST-1 of less than 100 pg/ml, 28 samples obtained from 12 patients were positive for TSST-1.", "output": {"entities": {"gene": [{"text": "TSST-1", "start": 24, "end": 30}, {"text": "TSST-1", "start": 110, "end": 116}]}}, "schema": []}
{"input": "Panlobular emphysema", "output": {"entities": {}}, "schema": []}
{"input": "Since the ETS domain, which is localized in the carboxy terminal region of the encoded protein, is 95% and 96% identical to that of PEA3 and ER81, respectively, we named this new member' Ets Related Molecule PEA3-like' (ERM).", "output": {"entities": {"gene": [{"text": "ETS domain", "start": 10, "end": 20}, {"text": "PEA3", "start": 132, "end": 136}, {"text": "ER81", "start": 141, "end": 145}, {"text": "' Ets Related Molecule PEA3-like'", "start": 185, "end": 218}, {"text": "ERM", "start": 220, "end": 223}]}}, "schema": []}
{"input": "Gel shift analysis indicates that the full-length ERM protein is able to bind specifically to an oligonucleotide containing the consensus nucleotide core sequence GGAA recognized by the Ets proteins.", "output": {"entities": {"gene": [{"text": "full-length ERM protein", "start": 38, "end": 61}, {"text": "Ets", "start": 186, "end": 189}]}}, "schema": []}
{"input": "Effects of estradiol on worm burden and peripheral leukocytes in Parastrongylus malaysiensis-infected rats.", "output": {"entities": {}}, "schema": []}
{"input": "Dotarizine produced arterial dilation in both systemic and pulmonary circulation: the total peripheral resistance dropped, and femoral artery flow rose; aortic and pulmonary artery mean and diastolic pressures declined, and systolic pressures remained almost stable.", "output": {"entities": {}}, "schema": []}
{"input": "These issues include the use of LMWHs in patients with arterial thrombosis or myocardial infarction (e. g. in conjunction with thrombolytic treatment), and in patients with pulmonary embolism.", "output": {"entities": {}}, "schema": []}
{"input": "The usefulness of the lambda PG15 and the lambda AD5 cloning vectors was demonstrated by constructing large Neurospora crassa cDNA libraries.", "output": {"entities": {}}, "schema": []}
{"input": "Endoscopic transthoracic sympathectomy as adjuvant treatment for critical upper-limb ischaemia.", "output": {"entities": {}}, "schema": []}
{"input": "Sequence comparisons have shown that Aps1p is more similar to the sigma subunit of the Golgi-localized mammalian AP-1 complex than Aps2p, which is more related to the plasma membrane AP-2 sigma subunit.", "output": {"entities": {"gene": [{"text": "Aps1p", "start": 37, "end": 42}, {"text": "AP-1 complex", "start": 113, "end": 125}, {"text": "Aps2p", "start": 131, "end": 136}, {"text": "AP-2 sigma", "start": 183, "end": 193}]}}, "schema": []}
{"input": "The Saccharomyces cerevisiae APS1 gene encodes a homolog of the small subunit of the mammalian clathrin AP-1 complex: evidence for functional interaction with clathrin at the Golgi complex.", "output": {"entities": {"gene": [{"text": "Saccharomyces cerevisiae APS1 gene", "start": 4, "end": 38}, {"text": "mammalian clathrin AP-1 complex", "start": 85, "end": 116}, {"text": "clathrin", "start": 159, "end": 167}]}}, "schema": []}
{"input": "These results are the first to demonstrate the structural organization of a vertebrate gene encoding an integral membrane protein of the nuclear envelope that may be a member of a family of polypeptides conserved in evolution.", "output": {"entities": {}}, "schema": []}
{"input": "Biochemical characterization of valosin-containing protein, a protein tyrosine kinase substrate in hematopoietic cells.", "output": {"entities": {"gene": [{"text": "valosin-containing protein", "start": 32, "end": 58}, {"text": "protein tyrosine kinase", "start": 62, "end": 85}]}}, "schema": []}
{"input": "The presence of the foreign gene was confirmed by Southern analysis.", "output": {"entities": {}}, "schema": []}
{"input": "All patients with deterioriation in mental status showed a marked increase in liver enzymes (aspartate and alanine aminotransaminases) and severe coagulopathy.", "output": {"entities": {"gene": [{"text": "aspartate and alanine aminotransaminases", "start": 93, "end": 133}]}}, "schema": []}
{"input": "Functional postnatal development of the rat primary visual cortex and the role of visual experience: dark rearing and monocular deprivation.", "output": {"entities": {}}, "schema": []}
{"input": "Eleven patients tested positive for the hepatitis B surface antigen (HBsAg).", "output": {"entities": {"gene": [{"text": "hepatitis B surface antigen", "start": 40, "end": 67}, {"text": "HBsAg", "start": 69, "end": 74}]}}, "schema": []}
{"input": "The xylose isomerase-encoding gene (xylA) of Clostridium thermosaccharolyticum: cloning, sequencing and phylogeny of XylA enzymes.", "output": {"entities": {"gene": [{"text": "xylose isomerase-encoding gene", "start": 4, "end": 34}, {"text": "xylA", "start": 36, "end": 40}, {"text": "XylA enzymes", "start": 117, "end": 129}]}}, "schema": []}
{"input": "Two phosphopeptides, identified as RS-[32P] SGASGLLTSEHHSR and S-[32P] SGASGLLTSEHHSR, were obtained after stoichiometric phosphorylation and trypsinization of the peptide.", "output": {"entities": {}}, "schema": []}
{"input": "Altogether, these data suggest that Ypt51p, Ypt52p, and Ypt53p are required for transport in the endocytic pathway and for correct sorting of vacuolar hydrolases suggesting a possible intersection of the endocytic with the vacuolar sorting pathway.", "output": {"entities": {"gene": [{"text": "Ypt51p", "start": 36, "end": 42}, {"text": "Ypt52p", "start": 44, "end": 50}, {"text": "Ypt53p", "start": 56, "end": 62}, {"text": "vacuolar hydrolases", "start": 142, "end": 161}]}}, "schema": []}
{"input": "All of the basal TPN solutions were isonitrogenous and identical in nutrient composition, except for the difference in energy level, which was adjusted with glucose.", "output": {"entities": {}}, "schema": []}
{"input": "Surprisingly, TFIIIC alpha has no homology to any of the yeast TFIIIC subunits already cloned, suggesting a significant degree of evolutionary divergence for RNA polymerase III factors.", "output": {"entities": {"gene": [{"text": "TFIIIC alpha", "start": 14, "end": 26}, {"text": "yeast TFIIIC subunits", "start": 57, "end": 78}, {"text": "RNA polymerase III factors", "start": 158, "end": 184}]}}, "schema": []}
{"input": "Transactivation domain is located downstream of the 128-amino-acid runt homology region, referred to as the Runt domain.", "output": {"entities": {"gene": [{"text": "128-amino-acid runt homology region", "start": 52, "end": 87}, {"text": "Runt domain", "start": 108, "end": 119}]}}, "schema": []}
{"input": "We estimate that the protease activity is at least 35-fold greater in mature B cells than in pre-B cells.", "output": {"entities": {}}, "schema": []}
{"input": "The ligand for RXR, 9-cis retinoic acid, has the opposite effect of destabilizing the heterodimeric-DNA complex.", "output": {"entities": {"gene": [{"text": "RXR", "start": 15, "end": 18}]}}, "schema": []}
{"input": "Cerebral125 albumin was increased to similar proportions in those groups submitted to hyperosmolality.", "output": {"entities": {"gene": [{"text": "Cerebral125 albumin", "start": 0, "end": 19}]}}, "schema": []}
{"input": "Retrogradely labelled neurons significantly prevailed in the ipsilateral substantia nigra pars compacta.", "output": {"entities": {}}, "schema": []}
{"input": "Therefore, the amino-terminal sequence of the purified carA product is identical to that derived from the nucleotide sequence in both organisms, P. stutzeri having four additional amino acids.", "output": {"entities": {"gene": [{"text": "carA product", "start": 55, "end": 67}]}}, "schema": []}
{"input": "Aneurysmal bone cyst of the jaws: analysis of 11 cases.", "output": {"entities": {}}, "schema": []}
{"input": "Location and orientation of an activating region in the Escherichia coli transcription factor, FNR.", "output": {"entities": {"gene": [{"text": "FNR", "start": 95, "end": 98}]}}, "schema": []}
{"input": "Moxidectin (at 3 times the therapeutic dose) did not have deleterious effects on cow reproductive performance as examined (eg, at folliculogenesis, ovulation, and the early embryonic phase of development).", "output": {"entities": {}}, "schema": []}
{"input": "Northern-blot analysis of mRNA from Avicel-grown N. patriciarum showed that xynB hybridized to a 3. 4 kb mRNA species.", "output": {"entities": {"gene": [{"text": "xynB", "start": 76, "end": 80}]}}, "schema": []}
{"input": "The variable regions of vertebrate striated TnT isoforms reflect the subsequent addition and modification of genomic sequences to give rise to members of the TnT multigene family.", "output": {"entities": {"gene": [{"text": "TnT isoforms", "start": 44, "end": 56}, {"text": "TnT multigene family", "start": 158, "end": 178}]}}, "schema": []}
{"input": "Simple reaction time (RT) to a peripheral visual target (S2) is shortened when a non-informative cue (S1) is flashed at the S2 location 100-150 ms before target onset (early facilitation).", "output": {"entities": {}}, "schema": []}
{"input": "These viruses depend on the host cell machinery for their existence, and interference with these processes typically interferes with other important host physiology.", "output": {"entities": {}}, "schema": []}
{"input": "Treatment was well-tolerated.", "output": {"entities": {}}, "schema": []}
{"input": "A concentration of 12. 5 ppm SO2 induced a decrease from baseline values of approximately 80% in mean MCA and of roughly 70% in mean CBF.", "output": {"entities": {}}, "schema": []}
{"input": "We have used these modified assay conditions to extend studies on the transposition pathway.", "output": {"entities": {}}, "schema": []}
{"input": "Renal cell carcinoma in children: a single institution' s experience.", "output": {"entities": {}}, "schema": []}
{"input": "The data suggest that ICP10 constitutively increases ras activity, and its TM segment plays a critical role in transformation-related signaling pathways.", "output": {"entities": {"gene": [{"text": "ICP10", "start": 22, "end": 27}, {"text": "ras", "start": 53, "end": 56}]}}, "schema": []}
{"input": "Five concensus poly A addition sites are located in the 350 base pairs immediately following the protein IX coding region.", "output": {"entities": {"gene": [{"text": "protein IX", "start": 97, "end": 107}]}}, "schema": []}
{"input": "Factors associated with intrafamilial transmission of hepatitis B virus infection in Korea.", "output": {"entities": {}}, "schema": []}
{"input": "Northern analysis, to search for a pcbAB transcript, showed no distinct transcript and indicated severely degraded mRNA.", "output": {"entities": {"gene": [{"text": "pcbAB transcript", "start": 35, "end": 51}]}}, "schema": []}
{"input": "The high degree of conservation between NQO2 and NQO1 gene organization and sequence confirmed that NQO2 gene encodes for a second member of the NQO gene family in human.", "output": {"entities": {"gene": [{"text": "NQO2", "start": 40, "end": 44}, {"text": "NQO1 gene", "start": 49, "end": 58}, {"text": "NQO2 gene", "start": 100, "end": 109}, {"text": "NQO gene family", "start": 145, "end": 160}]}}, "schema": []}
{"input": "The efficacy of a Propionibacterium acnes product for treatment of coliform mastitis was evaluated following intramammary infusion of Escherichia coli.", "output": {"entities": {}}, "schema": []}
{"input": "The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32.", "output": {"entities": {"gene": [{"text": "human eps15 gene", "start": 4, "end": 20}, {"text": "tyrosine kinase", "start": 33, "end": 48}]}}, "schema": []}
{"input": "The gene encoding the 105-kDa protein (p105) precursor of the p50 subunit of transcription factor NF-kappa B also encodes a p70 I kappa B protein, I kappa B gamma, which is identical to the C-terminal 607 amino acids of p105.", "output": {"entities": {"gene": [{"text": "105-kDa protein (p105) precursor", "start": 22, "end": 54}, {"text": "p50 subunit", "start": 62, "end": 73}, {"text": "NF-kappa B", "start": 98, "end": 108}, {"text": "p70 I kappa B protein", "start": 124, "end": 145}, {"text": "I kappa B gamma", "start": 147, "end": 162}, {"text": "p105", "start": 220, "end": 224}]}}, "schema": []}
{"input": "Alternative splicing of RNA transcripts encoded by the murine p105 NF-kappa B gene generates I kappa B gamma isoforms with different inhibitory activities.", "output": {"entities": {"gene": [{"text": "p105 NF-kappa B", "start": 62, "end": 77}, {"text": "I kappa B gamma isoforms", "start": 93, "end": 117}]}}, "schema": []}
{"input": "The experiment included 6 male and 4 female healthy subjects who, during a 24-hour stay in the respiration chambers, performed, in the morning and afternoon, 15 min cycling with the total work of 6, 750 kg m.", "output": {"entities": {}}, "schema": []}
{"input": "These rearrangements result in the formation of chimeric genes showing the tyrosine kinase domain of ret fused with the 5' end sequences of different genes.", "output": {"entities": {"gene": [{"text": "tyrosine kinase domain", "start": 75, "end": 97}, {"text": "ret", "start": 101, "end": 104}]}}, "schema": []}
{"input": "Frequent loss of heterozygosity (LOH) of > 30% of the informative cases was observed on chromosomes 3p (41. 1%), 5q (52. 6%), 6p (30. 4%), 8p (33. 3%), 9p (35. 7%), 9q (30. 8%), 11p (32. 4%), 13q (52. 7%), 17p (55. 2%), 17q (33. 3%), 18q (45. 7%), and 19q (30. 4%).", "output": {"entities": {}}, "schema": []}
{"input": "A single amino acid change in the CPY vacuolar sorting signal prevents this interaction.", "output": {"entities": {"gene": [{"text": "CPY vacuolar sorting signal", "start": 34, "end": 61}]}}, "schema": []}
{"input": "Glutamyl-tRNA synthetase and prolyl-tRNA synthetase belong to different classes of aminoacyl-tRNA synthetases that are thought to have evolved along independent evolutionary pathways.", "output": {"entities": {"gene": [{"text": "Glutamyl-tRNA synthetase", "start": 0, "end": 24}, {"text": "prolyl-tRNA synthetase", "start": 29, "end": 51}, {"text": "aminoacyl-tRNA synthetases", "start": 83, "end": 109}]}}, "schema": []}
{"input": "Using the sequence data obtained from the human TCRAC/TCRDC region, we have extended a polymerase chain reaction-based assay to test for the expression of the individual TCRAJ gene segments.", "output": {"entities": {"gene": [{"text": "TCRAC", "start": 48, "end": 53}, {"text": "TCRDC", "start": 54, "end": 59}, {"text": "TCRAJ gene segments", "start": 170, "end": 189}]}}, "schema": []}
{"input": "This analysis revealed an intact gene (arg4) showing a high degree of homology with the Saccharomyces cerevisiae CPA2 gene encoding the large subunit of carbamoyl-phosphate synthetase (CPS-A).", "output": {"entities": {"gene": [{"text": "arg4", "start": 39, "end": 43}, {"text": "Saccharomyces cerevisiae CPA2 gene", "start": 88, "end": 122}, {"text": "carbamoyl-phosphate synthetase", "start": 153, "end": 183}, {"text": "CPS-A", "start": 185, "end": 190}]}}, "schema": []}
{"input": "The baroreflex latency (from the ECG R-wave to the integrated MSNA burst peak) was constant at approximately 1. 20 s during sleep, suggesting that pulse-synchronicity was maintained.", "output": {"entities": {}}, "schema": []}
{"input": "DESIGN--A randomised study was conducted in all women aged 50-70 years who were eligible for breast cancer screening and living in the city of Utrecht.", "output": {"entities": {}}, "schema": []}
{"input": "Identification of an immediate-early gene in the Marek' s disease virus long internal repeat region which encodes a unique 14-kilodalton polypeptide.", "output": {"entities": {"gene": [{"text": "immediate-early gene", "start": 21, "end": 41}]}}, "schema": []}
{"input": "We have used a full-length cDNA clone of a mouse hepatitis virus strain A59 defective interfering (DI) RNA, pMIDI-C, and cassette mutagenesis to study the mechanism of coronavirus subgenomic mRNA synthesis.", "output": {"entities": {"gene": [{"text": "pMIDI-C", "start": 108, "end": 115}]}}, "schema": []}
{"input": "To study the structure-function of the gene 5 product, wild-type and mutant forms of NS53 were produced by using a recombinant baculovirus expression system and a recombinant vaccinia virus/T7 (vTF7-3) expression system.", "output": {"entities": {"gene": [{"text": "gene 5 product", "start": 39, "end": 53}, {"text": "NS53", "start": 85, "end": 89}]}}, "schema": []}
{"input": "Gel electrophoresis and Western immunoblot analyses of intracellular fractions derived from infected cells revealed that large amounts of NS53 were present in the cytosol and in association with the cytoskeletal matrix.", "output": {"entities": {"gene": [{"text": "NS53", "start": 138, "end": 142}]}}, "schema": []}
{"input": "The transcription factor AP-2 is encoded by a gene located on chromosome 6 near the HLA locus.", "output": {"entities": {"gene": [{"text": "transcription factor AP-2", "start": 4, "end": 29}, {"text": "HLA locus", "start": 84, "end": 93}]}}, "schema": []}
{"input": "The mature AP-2 mRNA is spliced from 7 exons distributed over a region of 18 kb genomic DNA.", "output": {"entities": {"gene": [{"text": "AP-2 mRNA", "start": 11, "end": 20}]}}, "schema": []}
{"input": "San Martin' s psychological traits coupled to his work with masonic lodges that allowed him to display his abilities as strategist and political ruler.", "output": {"entities": {}}, "schema": []}
{"input": "The participants were homosexual men in hepatitis B vaccine trials in Amsterdam (n = 74), New York City (n = 120), and San Francisco (n = 168).", "output": {"entities": {}}, "schema": []}
{"input": "Comparison with the crystal structure of Desulfovibrio gigas, Dg, Fd (Kissinger et al., 1991) reveals a very similar folding topology, although several secondary structural elements are extended in Pf relative to Dg Fd.", "output": {"entities": {"gene": [{"text": "Fd", "start": 66, "end": 68}, {"text": "Fd", "start": 216, "end": 218}]}}, "schema": []}
{"input": "CONCLUSIONS: Serum prolactin concentrations show age related variations in presumably fertile men.", "output": {"entities": {"gene": [{"text": "Serum prolactin", "start": 13, "end": 28}]}}, "schema": []}
{"input": "Eight highly trained male kayakers were studied to determine the relationship between critical power (CP) and the onset of blood lactate accumulation (OBLA).", "output": {"entities": {}}, "schema": []}
{"input": "As in S. cerevisiae, the sequence of rhp51 + showed two MluI cell-cycle boxes and a putative DNA damage-responsive element in its upstream region.", "output": {"entities": {"gene": [{"text": "rhp51 +", "start": 37, "end": 44}, {"text": "MluI cell-cycle boxes", "start": 56, "end": 77}]}}, "schema": []}
{"input": "A partial cDNA sequence indicated that the T lymphocyte early-activation gene (Tea) encodes a protein related to the dual-function ecotropic retrovirus receptor/cationic amino acid transporter (ecoR/CAT1), and RNA blots suggested highest Tea expression in T lymphocytes and liver (MacLeod, C. L., Finley, K., Kakuda, D.", "output": {"entities": {"gene": [{"text": "T lymphocyte early-activation gene", "start": 43, "end": 77}, {"text": "Tea", "start": 79, "end": 82}, {"text": "ecotropic retrovirus receptor", "start": 131, "end": 160}, {"text": "cationic amino acid transporter", "start": 161, "end": 192}, {"text": "ecoR", "start": 194, "end": 198}, {"text": "CAT1", "start": 199, "end": 203}, {"text": "Tea", "start": 238, "end": 241}]}}, "schema": []}
{"input": "Furthermore, unlike the case for HIS3 where only a limited subset of TATA-like sequences can activate transcription in conjunction with GCN4p, many divergent TATA-like sequences allowed GCN4p activation of TRP3.", "output": {"entities": {"gene": [{"text": "HIS3", "start": 33, "end": 37}, {"text": "GCN4p", "start": 136, "end": 141}, {"text": "GCN4p", "start": 186, "end": 191}, {"text": "TRP3", "start": 206, "end": 210}]}}, "schema": []}
{"input": "Bacterially expressed protein, as well as the in vitro reticulocyte lysate translation product, comigrated with the purified 37-kDa protein on sodium dodecyl sulfate-polyacrylamide gels.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, this kinase is well conserved evolutionarily, ubiquitously expressed, and its genes map to a position on human chromosome 1 frequently deleted in the late stages of tumorigenesis.", "output": {"entities": {}}, "schema": []}
{"input": "Deletion analysis of the ICL1 promoter led to the identification of an upstream activating sequence element, UASICL1 (5' CATTCATCCG 3'), necessary and sufficient for conferring carbon source-dependent regulation on a heterologous reporter gene.", "output": {"entities": {"gene": [{"text": "ICL1 promoter", "start": 25, "end": 38}]}}, "schema": []}
{"input": "In Mv1Lu lung epithelial cells, ActR-IB and T beta R-I signal a common set of growth-inhibitory and transcriptional responses in association with their corresponding ligands and type II receptors.", "output": {"entities": {"gene": [{"text": "ActR-IB", "start": 32, "end": 39}, {"text": "T beta R-I", "start": 44, "end": 54}, {"text": "type II receptors", "start": 178, "end": 195}]}}, "schema": []}
{"input": "H-7, which specifically, although weakly, inhibited PKC activation, had no effect on tyrosine phosphorylation and PtdIns (3, 4) P2 production.", "output": {"entities": {"gene": [{"text": "PKC", "start": 52, "end": 55}]}}, "schema": []}
{"input": "The effects of systemic glucose concentration on brain metabolism following repeated brain ischemia.", "output": {"entities": {}}, "schema": []}
{"input": "A-69-year-old patient with postoperative small-bowel obstruction underwent laparotomy three times.", "output": {"entities": {}}, "schema": []}
{"input": "On physical examination a mild symmetrical polyarthritis of small and large joints was seen.", "output": {"entities": {}}, "schema": []}
{"input": "We conclude that the SIMV is useful in weaning neonates from the ventilator.", "output": {"entities": {}}, "schema": []}
{"input": "VP-16, ifosfamide and cisplatin (VIP) for extensive small cell lung cancer.", "output": {"entities": {}}, "schema": []}
{"input": "A total of 7 (4 males and 3 females) patients were included in this retrospective study to determine the sensitivity of radioimmunoscintigraphy with I-131 labeled anti CEA/CA 19-9 monoclonal antibodies.", "output": {"entities": {"gene": [{"text": "anti CEA", "start": 163, "end": 171}, {"text": "CA 19-9", "start": 172, "end": 179}]}}, "schema": []}
{"input": "A genomic clone for the cyc07 gene, which is expressed specifically at the S phase during the cell cycle in synchronous cultures of periwinkle (Catharanthus roseus) cells, was isolated.", "output": {"entities": {"gene": [{"text": "cyc07 gene", "start": 24, "end": 34}]}}, "schema": []}
{"input": "CONCLUSIONS: Translocation of bacteria or endotoxin from the gastrointestinal tract into the bloodstream has been noted in animal experiments; however, translocation was not detected in our patients with hemorrhagic shock.", "output": {"entities": {}}, "schema": []}
{"input": "Southern blotting analysis implied the occurrence of multiple COXVb genes in the rat genome.", "output": {"entities": {"gene": [{"text": "COXVb genes", "start": 62, "end": 73}]}}, "schema": []}
{"input": "Acylation with the palmitate analog was prevented when Gly-2 was mutated to alanine, implying that N-myristylation is required for palmitylation, and when either Cys-3 or Cys-6 was mutated to serine.", "output": {"entities": {}}, "schema": []}
{"input": "Subunit composition and domain structure of the Spo0A sporulation transcription factor of Bacillus subtilis.", "output": {"entities": {"gene": [{"text": "Spo0A sporulation transcription factor of Bacillus subtilis", "start": 48, "end": 107}]}}, "schema": []}
{"input": "Electrophoretic mobility shift analysis indicates that NF-IL-6, as well as other related members of this family, bind specifically to the NF-IL-6 site in the IL-8 promoter.", "output": {"entities": {"gene": [{"text": "NF-IL-6", "start": 55, "end": 62}, {"text": "NF-IL-6", "start": 138, "end": 145}, {"text": "IL-8 promoter", "start": 158, "end": 171}]}}, "schema": []}
{"input": "BYV, citrus tristeza virus (CTV), beet yellow stunt virus (BYSV) and carnation necrotic fleck virus templates produced 1 kb amplification products, which were shown by sequencing to represent fragments of the respective HSP70 genes.", "output": {"entities": {"gene": [{"text": "HSP70 genes", "start": 220, "end": 231}]}}, "schema": []}
{"input": "The p53 tumor suppressor gene product, a sequence-specific DNA-binding protein, has been shown to act as a transcriptional activator and repressor both in vitro and in vivo.", "output": {"entities": {"gene": [{"text": "p53 tumor suppressor gene product", "start": 4, "end": 37}]}}, "schema": []}
{"input": "Mutational analysis of chromosomal segment 64AB, a region containing the glutamic acid decarboxylase gene.", "output": {"entities": {"gene": [{"text": "glutamic acid decarboxylase gene", "start": 73, "end": 105}]}}, "schema": []}
{"input": "Rearrangements of the NFKB2 gene are associated with lymphoid malignancies, but the functional significance of these alterations is not known.", "output": {"entities": {"gene": [{"text": "NFKB2 gene", "start": 22, "end": 32}]}}, "schema": []}
{"input": "Cloning and sequencing of the corresponding cDNAs indicates that, via alternative splicing, the rearranged gene codes for two proteins of 84 and 85 kD (p84/85) which retain the DNA-binding rel domain and the first five ankyrin repeats, but have lost their carboxy-terminus including the seventh ankyrin repeat.", "output": {"entities": {"gene": [{"text": "p84/85", "start": 152, "end": 158}, {"text": "rel domain", "start": 189, "end": 199}, {"text": "ankyrin", "start": 219, "end": 226}, {"text": "ankyrin", "start": 295, "end": 302}]}}, "schema": []}
{"input": "Transient co-transfection assays involving NFKB2 expression vectors and kappa B-driven reporter plasmids indicate that NFKB2 p85 has lost the transcriptional repressor functions typical of normal NFKB2 p52.", "output": {"entities": {"gene": [{"text": "NFKB2", "start": 43, "end": 48}, {"text": "kappa B", "start": 72, "end": 79}, {"text": "NFKB2 p85", "start": 119, "end": 128}, {"text": "NFKB2 p52", "start": 196, "end": 205}]}}, "schema": []}
{"input": "Also, HR21ap as well as HR21Xap are specific in their inhibition of Sp1 binding.", "output": {"entities": {"gene": [{"text": "HR21ap", "start": 6, "end": 12}, {"text": "HR21Xap", "start": 24, "end": 31}, {"text": "Sp1", "start": 68, "end": 71}]}}, "schema": []}
{"input": "Intravenous antibiotic therapy in cystic fibrosis: in hospital or at home?", "output": {"entities": {}}, "schema": []}
{"input": "Open reading frames in a 4556 nucleotide sequence within MDV-1 BamHI-D DNA fragment: evidence for splicing of mRNA from a new viral glycoprotein gene.", "output": {"entities": {"gene": [{"text": "MDV-1 BamHI-D DNA fragment", "start": 57, "end": 83}]}}, "schema": []}
{"input": "The ns2 gene comprises an open reading frame (ORF) encoding a putative nonstructural (ns) protein of 279 amino acids with a predicted molecular mass of 32-kDa.", "output": {"entities": {"gene": [{"text": "ns2 gene", "start": 4, "end": 12}]}}, "schema": []}
{"input": "The hydrophobicity profile of the methyltransferase reveals the presence of at least five potential transmembrane domains.", "output": {"entities": {}}, "schema": []}
{"input": "Measurement of SaO2 at moderate altitude can be helpful in the care of both healthy and ill newborns or infants.", "output": {"entities": {}}, "schema": []}
{"input": "To determine whether the excess prevalence of human immunodeficiency virus type 1 (HIV-1) infection in US black and Hispanic homosexual men relative to white men can be explained by differences in sociodemographic factors, history of sexually transmitted diseases, or sexual and drug-use behaviors, the authors conducted a cross-sectional analysis of baseline HIV-1 seroprevalence and HIV-1 risk factors among 4, 475 non-Hispanic white, 234 Hispanic white, and 194 black homosexual men from four centers in the United States (Baltimore/Washington, DC, Pittsburgh, Chicago, and Los Angeles).", "output": {"entities": {}}, "schema": []}
{"input": "The patients in one group had intrauterine catheters inserted and oxytocin was titrated to achieve the 75th percentile of uterine activity observed in spontaneous normal labour according to parity.", "output": {"entities": {"gene": [{"text": "oxytocin", "start": 66, "end": 74}]}}, "schema": []}
{"input": "Continued development of the rat conditioning paradigm is especially warranted because of the ability to record sympathetic nerve activity in intact, awake subjects and the large number of readily available genetic strains, which model human pathological states.", "output": {"entities": {}}, "schema": []}
{"input": "The ultrastructure of retinal vessels was examined in three eyes from diabetic patients and two eyes from control subjects.", "output": {"entities": {}}, "schema": []}
{"input": "The regulatory region also has a sequence similar to the binding site for a liver-specific transcription factor, hepatocyte nuclear factor 1 (HNF-1), at positions-120 to-132.", "output": {"entities": {"gene": [{"text": "hepatocyte nuclear factor 1", "start": 113, "end": 140}, {"text": "HNF-1", "start": 142, "end": 147}]}}, "schema": []}
{"input": "Thus, we have identified a GRE sufficient to account for full glucocorticoid inducibility and an HNF-1 site close to the promoter that are major determinants of transcriptional control of the Xenopus fibrinogen B beta subunit gene in cells from normal liver tissue.", "output": {"entities": {"gene": [{"text": "HNF-1 site", "start": 97, "end": 107}, {"text": "Xenopus fibrinogen B beta subunit gene", "start": 192, "end": 230}]}}, "schema": []}
{"input": "Acad.", "output": {"entities": {}}, "schema": []}
{"input": "The PRB-1b gene encodes for a basic-type component of the pathogenesis-related PR-1 protein family.", "output": {"entities": {"gene": [{"text": "PRB-1b gene", "start": 4, "end": 15}, {"text": "PR-1 protein family", "start": 79, "end": 98}]}}, "schema": []}
{"input": "Replacement of the CRE with a second copy of the AP-1 site results in a level of transcriptional activity comparable with that of the wild-type sequence, but replacement of the AP-1 site with a CRE abolishes activity.", "output": {"entities": {"gene": [{"text": "AP-1 site", "start": 49, "end": 58}, {"text": "AP-1 site", "start": 177, "end": 186}]}}, "schema": []}
{"input": "The T-cyt promoter, although of bacterial origin is active in planta and the 30 bp cyt-1 element is located within a region that is essential for T-cyt promotor activity in leaf, stem and root cells of tobacco plants.", "output": {"entities": {"gene": [{"text": "T-cyt promoter", "start": 4, "end": 18}, {"text": "30 bp cyt-1 element", "start": 77, "end": 96}, {"text": "T-cyt promotor", "start": 146, "end": 160}]}}, "schema": []}
{"input": "Reviewing manuscripts: developing an efficient system.", "output": {"entities": {}}, "schema": []}
{"input": "We suggest that CT scan be preferable in diagnosis of tumors in that area.", "output": {"entities": {}}, "schema": []}
{"input": "Effect of aging on respiratory skeletal muscles.", "output": {"entities": {}}, "schema": []}
{"input": "Two BASIC computer programs using logit transformation for the analysis of S-shaped curves are presented.", "output": {"entities": {}}, "schema": []}
{"input": "The yeast SSS1 gene is essential for secretory protein translocation and encodes a conserved protein of the endoplasmic reticulum.", "output": {"entities": {"gene": [{"text": "yeast SSS1 gene", "start": 4, "end": 19}]}}, "schema": []}
{"input": "The lengths of the complete polypeptide chain of the recombinant enzyme and its transit peptide are 388 and 53 residues, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "The absence of H4PteGlun bound to the T protein in our experimental conditions demonstrates that H4PteGlun is not covalently linked to the T protein.", "output": {"entities": {"gene": [{"text": "T protein", "start": 38, "end": 47}, {"text": "T protein", "start": 139, "end": 148}]}}, "schema": []}
{"input": "TATA and CCAAT boxes are located 34-bp and 68-bp, respectively, upstream of the transcription start site, the 5'-untranslated leader is 78 nucleotides long, and the intronless gene has at least two different polyadenylation sites.", "output": {"entities": {}}, "schema": []}
{"input": "GGS1 is the same gene as TPS1 which was identified as encoding a subunit of the trehalose-6-phosphate synthase/phosphatase complex and it is allelic to the fdp1, byp1, glc6 and cif1 mutations.", "output": {"entities": {"gene": [{"text": "GGS1", "start": 0, "end": 4}, {"text": "TPS1", "start": 25, "end": 29}, {"text": "trehalose-6-phosphate synthase/phosphatase complex", "start": 80, "end": 130}, {"text": "fdp1", "start": 156, "end": 160}, {"text": "byp1", "start": 162, "end": 166}, {"text": "glc6", "start": 168, "end": 172}]}}, "schema": []}
{"input": "We also compared the sequence with the partly homologous products of the S. cerevisiae genes TPS2 and TSL1 which code for the larger subunits of the trehalose synthase complex and with a TSL1 homologue, TPS3, of unknown function.", "output": {"entities": {"gene": [{"text": "TPS2", "start": 93, "end": 97}, {"text": "TSL1", "start": 102, "end": 106}, {"text": "trehalose synthase complex", "start": 149, "end": 175}, {"text": "TSL1 homologue", "start": 187, "end": 201}, {"text": "TPS3", "start": 203, "end": 207}]}}, "schema": []}
{"input": "Stroop interference: aging effects assessed with the Stroop Color-Word Test.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSION: The study demonstrates that transvaginal ultrasonography has an efficiency of 88% in differentiating endometriomas from other ovarian masses with a specificity of 90%.", "output": {"entities": {}}, "schema": []}
{"input": "Genomic Southern blot analysis of rat EFIA (gene encoding enhancer factor I subunit A) reveals a complex band pattern when cDNA subfragment probes are used.", "output": {"entities": {"gene": [{"text": "rat EFIA", "start": 34, "end": 42}, {"text": "enhancer factor I subunit A", "start": 58, "end": 85}]}}, "schema": []}
{"input": "The effect of ibopamine and furosemide in 130 patients with NYHA Class I and II heart failure were studied in a parallel, double-blind, randomized placebo-controlled multi-centre trial.", "output": {"entities": {}}, "schema": []}
{"input": "The nit-3 gene of the filamentous fungus Neurospora crassa encodes nitrate reductase, the enzyme which catalyzes the first step in nitrate assimilation.", "output": {"entities": {"gene": [{"text": "nit-3 gene of the filamentous fungus Neurospora crassa", "start": 4, "end": 58}, {"text": "nitrate reductase", "start": 67, "end": 84}]}}, "schema": []}
{"input": "Unfolding can be described by a two-state process since a ratio of delta Hcalorimetric to delta Hvan' t Hoff equals 0. 96.", "output": {"entities": {}}, "schema": []}
{"input": "This motif has been shown to mediate protein interactions in the case of ankyrin as well as several other repeat-bearing proteins.", "output": {"entities": {"gene": [{"text": "ankyrin", "start": 73, "end": 80}]}}, "schema": []}
{"input": "[Ala85] Dk (69-85) retains full biological activity.", "output": {"entities": {"gene": [{"text": "[Ala85] Dk (69-85)", "start": 0, "end": 18}]}}, "schema": []}
{"input": "The major myosin-binding domain of skeletal muscle MyBP-C (C protein) resides in the COOH-terminal, immunoglobulin C2 motif.", "output": {"entities": {"gene": [{"text": "myosin-binding domain", "start": 10, "end": 31}, {"text": "skeletal muscle MyBP-C", "start": 35, "end": 57}, {"text": "C protein", "start": 59, "end": 68}, {"text": "immunoglobulin C2 motif", "start": 100, "end": 123}]}}, "schema": []}
{"input": "Our results indicate that periseizure lipid accumulation is related to cortical oxygenation.", "output": {"entities": {}}, "schema": []}
{"input": "We conclude that the QLMI questionnaire has good potential as an instrument for assessing QL in post-AMI patients and that it can be successfully self-administered.", "output": {"entities": {}}, "schema": []}
{"input": "Most smokers would prefer to quit smoking on their own.", "output": {"entities": {}}, "schema": []}
{"input": "The inhibitory response to taps is essentially a protective reflex which probably serves to reduce the activity of the jaw-closing muscles when one bites unexpectedly on hard objects.", "output": {"entities": {}}, "schema": []}
{"input": "The action of nef was specific to the LTR, as expression of nef had no effect on the activity of the simian virus 40, c-fms, urokinase plasminogen activator, or type 5 acid phosphatase promoter. trans-activating activity was also manifested by a frameshift mutant expressing only the first 35 amino acids of the protein.", "output": {"entities": {"gene": [{"text": "nef", "start": 14, "end": 17}, {"text": "nef", "start": 60, "end": 63}, {"text": "c-fms", "start": 118, "end": 123}, {"text": "urokinase plasminogen activator", "start": 125, "end": 156}, {"text": "type 5 acid phosphatase promoter", "start": 161, "end": 193}]}}, "schema": []}
{"input": "The product of the vpr open reading frame of human immunodeficiency virus type 1 (HIV-1) is a 15-kDa, arginine-rich protein that is present in virions in molar quantities equivalent to that of Gag.", "output": {"entities": {"gene": [{"text": "vpr open reading frame of human immunodeficiency virus type 1 (HIV-1)", "start": 19, "end": 88}, {"text": "Gag", "start": 193, "end": 196}]}}, "schema": []}
{"input": "The recombinant vaccinia virus-expressed mutant P1 polyproteins were analyzed for proteolytic processing defects in cells coinfected with a recombinant vaccinia virus (VVP3) that expresses the poliovirus 3CD protease and for processing and assembly defects by using a trans complementation system in which P1-expressing recombinant vaccinia viruses provide capsid precursor to a defective poliovirus genome that does not express functional capsid proteins (D.", "output": {"entities": {"gene": [{"text": "recombinant vaccinia virus-expressed mutant P1 polyproteins", "start": 4, "end": 63}, {"text": "poliovirus 3CD protease", "start": 193, "end": 216}, {"text": "P1", "start": 306, "end": 308}, {"text": "capsid precursor", "start": 357, "end": 373}, {"text": "capsid proteins", "start": 440, "end": 455}]}}, "schema": []}
{"input": "In contrast, capsid proteins derived from the P1 precursor with a valine substitution at the amino terminus of VP1 (VP1-G001V) assembled empty capsid particles but were deficient in assembling RNA-containing virions.", "output": {"entities": {"gene": [{"text": "capsid proteins", "start": 13, "end": 28}, {"text": "P1 precursor", "start": 46, "end": 58}, {"text": "VP1", "start": 111, "end": 114}, {"text": "VP1-G001V", "start": 116, "end": 125}]}}, "schema": []}
{"input": "RESULTS: In an 18 moth period and out of a total of 284 positive blood cultures (154 significant isolations) 14 episodes of bacteremia by M. tuberculosis were studied in 12 prison patients coinfected by the human immunodeficiency virus with associated severe immunosuppression (mean of CD4 = 0. 068 x 10 (9)/l).", "output": {"entities": {"gene": [{"text": "CD4", "start": 286, "end": 289}]}}, "schema": []}
{"input": "Acid instilled on the larynx of maturing rabbits resulted in significant obstructive, central, and mixed apnea.", "output": {"entities": {}}, "schema": []}
{"input": "By using total-protein extracts from mycelia grown under penicillin producing conditions we have detected a DNA-binding activity that specifically shifts a promoter fragment located between-654 and-455 (relative to IPNS tsp).", "output": {"entities": {"gene": [{"text": "IPNS tsp", "start": 215, "end": 223}]}}, "schema": []}
{"input": "Similar synergistic activation was observed in the IL-8 promoter, which also contains both NF-IL6 and NF-kappa B binding sites.", "output": {"entities": {"gene": [{"text": "IL-8 promoter", "start": 51, "end": 64}, {"text": "NF-IL6", "start": 91, "end": 97}, {"text": "NF-kappa B binding sites", "start": 102, "end": 126}]}}, "schema": []}
{"input": "Notice of retraction.", "output": {"entities": {}}, "schema": []}
{"input": "No homology was found between the 36K protein and known structures of proteins.", "output": {"entities": {}}, "schema": []}
{"input": "We report an odd case of marked enlargement of suprapineal recess in a patient with triventricular hydrocephalus.", "output": {"entities": {}}, "schema": []}
{"input": "At a PaCO2 of 40 mmHg, baseline brain pHi measured 7. 03 +/-0. 04, while regional cortical blood flow was 47. 0 +/-4. 3 ml. 100 g-1. min-1.", "output": {"entities": {}}, "schema": []}
{"input": "CPAP reduced isotime (defined as the last common minute of exercise) VO2 and dyspnea in those patients with more severe lung disease, but these values tended to increase slightly in the patients with only mild lung disease.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of diltiazem on netilmicin-induced nephrotoxicity in rabbits.", "output": {"entities": {}}, "schema": []}
{"input": "Four forms of salmonellosis were recognised in feedlots and during transport by sea: septicaemic, and acute, subacute and chronic enteric.", "output": {"entities": {}}, "schema": []}
{"input": "About 20% of single-stranded DNA binding was observed in the presence of MgdTDP, but none was detectable in the absence of nucleotides.", "output": {"entities": {}}, "schema": []}
{"input": "Both 4, 8-DiMeIQx and A alpha C were found at < 1 p. p. b.", "output": {"entities": {}}, "schema": []}
{"input": "Three cysteine and four tryptophan residues, previously identified as conserved amongst nitrous-oxide reductases, are found in the Paracoccus enzyme.", "output": {"entities": {"gene": [{"text": "nitrous-oxide reductases", "start": 88, "end": 112}]}}, "schema": []}
{"input": "Recombinant Leishmania surface glycoprotein GP63 is secreted in the baculovirus expression system as a latent metalloproteinase.", "output": {"entities": {"gene": [{"text": "Recombinant Leishmania surface glycoprotein GP63", "start": 0, "end": 48}, {"text": "metalloproteinase", "start": 110, "end": 127}]}}, "schema": []}
{"input": "Delineating the molecular basis for agonist-induced destabilization of mRNA of G-protein-linked receptors that contributes to receptor down-regulation is fundamental to our understanding of long-term regulation of receptors by agonist.", "output": {"entities": {"gene": [{"text": "G-protein-linked receptors", "start": 79, "end": 105}]}}, "schema": []}
{"input": "These cells produce a low level of IL-5 when stimulated with PMA alone; however, N6, O2-dibutyryl cAMP (Bt2cAMP), in combination with PMA, augmented by more than tenfold the IL-5 production at the mRNA and the protein levels.", "output": {"entities": {"gene": [{"text": "IL-5", "start": 35, "end": 39}, {"text": "IL-5", "start": 174, "end": 178}]}}, "schema": []}
{"input": "Hu-Met-1 mRNA expression in a small number of human T cell tumor lines did not correlate with any particular phenotype or stage of development.", "output": {"entities": {"gene": [{"text": "Hu-Met-1 mRNA", "start": 0, "end": 13}]}}, "schema": []}
{"input": "Partial engorgement was higher in the treatments.", "output": {"entities": {}}, "schema": []}
{"input": "In addition to the protein-tyrosine kinase domain, p56lck possesses Src homology 2 and 3 (SH2 and SH3) domains as well as a unique N-terminal region.", "output": {"entities": {"gene": [{"text": "protein-tyrosine kinase domain", "start": 19, "end": 49}, {"text": "p56lck", "start": 51, "end": 57}, {"text": "Src homology 2 and 3", "start": 68, "end": 88}, {"text": "SH2", "start": 90, "end": 93}, {"text": "SH3", "start": 98, "end": 101}]}}, "schema": []}
{"input": "Strains bearing the drs2 mutation process the 20S precursor of the mature 18S rRNA slowly and are deficient in 40S ribosomal subunits.", "output": {"entities": {"gene": [{"text": "drs2 mutation", "start": 20, "end": 33}, {"text": "20S precursor", "start": 46, "end": 59}, {"text": "mature 18S rRNA", "start": 67, "end": 82}, {"text": "40S ribosomal subunits", "start": 111, "end": 133}]}}, "schema": []}
{"input": "Hepatitis B and liver transplantation.", "output": {"entities": {}}, "schema": []}
{"input": "These combined observations define a promoter and an enhancer for the chicken L-CAM gene.", "output": {"entities": {"gene": [{"text": "chicken L-CAM gene", "start": 70, "end": 88}]}}, "schema": []}
{"input": "Clipping resulted in a serious mislocalization of the position of the peak of the epicortical potential field.", "output": {"entities": {}}, "schema": []}
{"input": "The duration of diabetes mellitus in these patients was from 5 months to 6 years, and in all patients this was the first myocardial infarction.", "output": {"entities": {}}, "schema": []}
{"input": "The 247-kDa complex appears to contain two distinct protein-DNA complexes of approximately 232 and 256 kDa and represents two proteins covalently cross-linked to a single DRE oligonucleotide, while the 97, 105, and 115-kDa complexes represent single protein-DRE cross-links.", "output": {"entities": {}}, "schema": []}
{"input": "The promoter and upstream region of the Brassica napus 2S storage protein napA gene were studied to identify cis-acting sequences involved in developmental seed-specific expression.", "output": {"entities": {"gene": [{"text": "Brassica napus 2S storage protein napA gene", "start": 40, "end": 83}]}}, "schema": []}
{"input": "However, limited comparisons reveal domains in the NH2 and COOH termini that have a high degree of similarity suggesting functional conservation.", "output": {"entities": {}}, "schema": []}
{"input": "Rinit reflects the Newtonian resistances and Rdiff represents the viscoelastic/inhomogeneous pressure dissipations in the system.", "output": {"entities": {}}, "schema": []}
{"input": "We have explored the mechanism of action of the fibronectin splicing enhancer and found that the SE element is required for efficient assembly of early splicing complexes, allowing a more efficient interaction of the U2 snRNP with branch site sequences.", "output": {"entities": {"gene": [{"text": "fibronectin splicing enhancer", "start": 48, "end": 77}, {"text": "U2 snRNP", "start": 217, "end": 225}]}}, "schema": []}
{"input": "Inspection of enhancer mutants suggests that trans-activation by hLEF/GAL4 is especially dependent on TCF-2, a distinct T-cell-enriched protein that binds to sequences flanking the hLEF-binding site in the enhancer.", "output": {"entities": {"gene": [{"text": "hLEF", "start": 65, "end": 69}, {"text": "GAL4", "start": 70, "end": 74}, {"text": "TCF-2", "start": 102, "end": 107}, {"text": "hLEF-binding site", "start": 181, "end": 198}]}}, "schema": []}
{"input": "We conclude that sequences outside of the hLEF HMG box mediate cell-and context-specific activation of the TCR alpha enhancer and may facilitate interactions between hLEF and other T-cell-specific factors recruited to the enhancer.", "output": {"entities": {"gene": [{"text": "hLEF HMG box", "start": 42, "end": 54}, {"text": "TCR alpha enhancer", "start": 107, "end": 125}, {"text": "hLEF", "start": 166, "end": 170}]}}, "schema": []}
{"input": "A cAMP response element (CRE) consensus signal was identified in the 5'-noncoding region. cAMP regulates the expression of Kv1. 5 gene in a cell-specific manner.", "output": {"entities": {"gene": [{"text": "Kv1. 5 gene", "start": 123, "end": 134}]}}, "schema": []}
{"input": "A number of serological tests measuring the presence of Helicobacter pylori-specific serum immunoglobulin G (IgG) are now commercially available.", "output": {"entities": {"gene": [{"text": "immunoglobulin G", "start": 91, "end": 107}, {"text": "IgG", "start": 109, "end": 112}]}}, "schema": []}
{"input": "Using a series of mutant T antigens expressed by recombinant baculoviruses in Sf9 cells, we find that the origin unwinding activities of both TS677--> A and TS677, 679--> A are inhibited by the T-antigen kinase, as is wild-type T antigen.", "output": {"entities": {"gene": [{"text": "mutant T antigens", "start": 18, "end": 35}, {"text": "T-antigen kinase", "start": 194, "end": 210}, {"text": "wild-type T antigen", "start": 218, "end": 237}]}}, "schema": []}
{"input": "The degree of hypoperfusion was slightly related to decrease in FEV1. 0%, V25 and PaO2 and increase in circulating blood volume and peripheral red blood cell counts.", "output": {"entities": {}}, "schema": []}
{"input": "In the present study, lesions of the OPT complex (the thalamic source of afferents to IHA and HD) were found to have no effect on color-reversal learning performance.", "output": {"entities": {}}, "schema": []}
{"input": "The fourth dose produced favorable results (66. 7%) in individuals with HB antibodies between 10 and 100 IU/ml and unfavorable ones (3. 8%) where the HB antibodies were below 10 IU/ml.", "output": {"entities": {"gene": [{"text": "HB antibodies", "start": 72, "end": 85}, {"text": "HB antibodies", "start": 150, "end": 163}]}}, "schema": []}
{"input": "CONCLUSIONS: In our patients and within the range of treatment variables studied, age, Karnofsky index, and graft-versus-host disease are the most important factors related with early mortality.", "output": {"entities": {}}, "schema": []}
{"input": "Nucleotide sequence analysis of the HA gene in these two mutants confirmed the HA-phenotype.", "output": {"entities": {"gene": [{"text": "HA gene", "start": 36, "end": 43}, {"text": "HA-", "start": 79, "end": 82}]}}, "schema": []}
{"input": "This intron occupies a conserved position corresponding to that of intron 1 in the transit peptide region of chloroplast GAPDH genes (GapA and GapB) of higher plants.", "output": {"entities": {"gene": [{"text": "chloroplast GAPDH genes", "start": 109, "end": 132}, {"text": "GapA", "start": 134, "end": 138}, {"text": "GapB", "start": 143, "end": 147}]}}, "schema": []}
{"input": "The drug-resistant cell lines P388/ADR/3 and P388/ADR/7 express a shortened topo II alpha mRNA transcript in addition to the native transcript present in the drug-sensitive P388/4 cell line.", "output": {"entities": {"gene": [{"text": "topo II alpha mRNA transcript", "start": 76, "end": 105}]}}, "schema": []}
{"input": "Using a 3'-rapid amplification of cDNA ends strategy, we have cloned cDNAs representing the 3'-termini of both the native and mutant transcripts from both P388/ADR/3 and P388/ADR/7 cells.", "output": {"entities": {}}, "schema": []}
{"input": "The phi AP3 factor is a nuclear phosphoprotein; the extent of its phosphorylation is regulated during the cell cycle.", "output": {"entities": {"gene": [{"text": "phi AP3 factor", "start": 4, "end": 18}]}}, "schema": []}
{"input": "Similarly, the N-terminal cytoplasmic domain of the latent membrane protein 2A (LMP2A) of the Epstein-Barr virus (EBV) contains a single copy of the Tyr-X-X-Leu/Ile-containing motif which could play a critical role in B cell transformation.", "output": {"entities": {"gene": [{"text": "latent membrane protein 2A", "start": 52, "end": 78}, {"text": "LMP2A", "start": 80, "end": 85}]}}, "schema": []}
{"input": "The functional homology of Cwg2 with Cdc43, which has been implicated in the control of cell polarity, suggests a link between two morphogenetic events such as establishment of cell polarity and cell wall biosynthesis.", "output": {"entities": {"gene": [{"text": "Cwg2", "start": 27, "end": 31}, {"text": "Cdc43", "start": 37, "end": 42}]}}, "schema": []}
{"input": "Molecular cloning of a P-type ATPase gene from the cyanobacterium Synechocystis sp.", "output": {"entities": {"gene": [{"text": "P-type ATPase gene", "start": 23, "end": 41}]}}, "schema": []}
{"input": "The cloning of PTR2 represents the first example of the molecular genetic characterization of a eucaryotic peptide transport gene.", "output": {"entities": {"gene": [{"text": "PTR2", "start": 15, "end": 19}]}}, "schema": []}
{"input": "To examine the biochemical basis of the end joining, nuclear extracts were prepared from a wide variety of mammalian cell lines and tested for their ability to join test plasmid substrates.", "output": {"entities": {}}, "schema": []}
{"input": "These data indicate that the largest subunit of RNA polymerase II and TFIIB are important determinants of transcription start site selection in S. cerevisiae and suggest that this function might be conferred by interaction between these two proteins.", "output": {"entities": {"gene": [{"text": "RNA polymerase II", "start": 48, "end": 65}, {"text": "TFIIB", "start": 70, "end": 75}]}}, "schema": []}
{"input": "Recombinant expression of a chimeric EGFR/ErbB-3 receptor in NIH 3T3 fibroblasts allowed us to investigate cytoplasmic events associated with ErbB-3 signal transduction upon ligand activation.", "output": {"entities": {"gene": [{"text": "EGFR", "start": 37, "end": 41}, {"text": "ErbB-3 receptor", "start": 42, "end": 57}, {"text": "ErbB-3", "start": 142, "end": 148}]}}, "schema": []}
{"input": "Analysis of strains harboring an mds1 null mutation demonstrates that MDS1 is not essential during normal vegetative growth but appears to be required for meiosis.", "output": {"entities": {"gene": [{"text": "mds1 null mutation", "start": 33, "end": 51}, {"text": "MDS1", "start": 70, "end": 74}]}}, "schema": []}
{"input": "Val--> Ala mutations selectively alter helix-helix packing in the transmembrane segment of phage M13 coat protein.", "output": {"entities": {"gene": [{"text": "phage M13 coat protein", "start": 91, "end": 113}]}}, "schema": []}
{"input": "Strategic change in the NHS.", "output": {"entities": {}}, "schema": []}
{"input": "A much less expensive solution than UW, containing only K (+)-lactobionate, KH2PO4, MgSO4 and raffinose, can be used successfully for preservation of rat hepatocytes for 24 hr for drug transport studies.", "output": {"entities": {}}, "schema": []}
{"input": "Human bcl3 protein specifically displaces (p50) 2-DNA complexes.", "output": {"entities": {"gene": [{"text": "Human bcl3 protein", "start": 0, "end": 18}, {"text": "(p50) 2-DNA complexes", "start": 42, "end": 63}]}}, "schema": []}
{"input": "In vitro translation experiments show that human cDNA derived RNA translates into a protein with a mobility of 44-46 kD on SDS polyacrylamide gels.", "output": {"entities": {}}, "schema": []}
{"input": "After peripheral administration of both CRF and TRH, ACTH levels were significantly higher on the tumor side in all patients.", "output": {"entities": {"gene": [{"text": "CRF", "start": 40, "end": 43}, {"text": "TRH", "start": 48, "end": 51}, {"text": "ACTH", "start": 53, "end": 57}]}}, "schema": []}
{"input": "A sequence homology analysis between human nm23-H1 and the homolog gene of the rat (NDP-K beta) shows that exon-intron boundaries are well conserved between these two species.", "output": {"entities": {"gene": [{"text": "human nm23-H1", "start": 37, "end": 50}, {"text": "NDP-K beta", "start": 84, "end": 94}]}}, "schema": []}
{"input": "A favourable response was achieved with a combination of amphotericin B and cotrimoxazole.", "output": {"entities": {}}, "schema": []}
{"input": "Response durations were short.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: At the beginning of the QA/QI process, monitoring of blood administration practices revealed that a variance from institutional blood administration policy occurred during 50 percent of blood and component transfusions.", "output": {"entities": {}}, "schema": []}
{"input": "Drug effect, measured as postural sway, was also similar in the patients with cirrhosis and control subjects; therefore the ratio of effect area under the curve to concentration area under the curve, a measure of sensitivity, did not differ significantly between the patients with cirrhosis and the control subjects.", "output": {"entities": {}}, "schema": []}
{"input": "We present evidence that YY1, a ubiquitously expressed DNA-binding protein, regulates the activity of the c-fos promoter primarily through an effect on DNA structure.", "output": {"entities": {"gene": [{"text": "YY1", "start": 25, "end": 28}, {"text": "c-fos promoter", "start": 106, "end": 120}]}}, "schema": []}
{"input": "In a retrospective analysis of first-time total colonoscopies in 685 patients, we investigated the relationship between hyperplastic and adenomatous polyps.", "output": {"entities": {}}, "schema": []}
{"input": "The rate of decrement in DPOAE amplitude over a prescribed time period was utilized as a measure of susceptibility to the acoustic trauma.", "output": {"entities": {}}, "schema": []}
{"input": "Effect of single base substitutions at glycine-870 codon of gramicidin S synthetase 2 gene on proline activation.", "output": {"entities": {"gene": [{"text": "gramicidin S synthetase 2 gene", "start": 60, "end": 90}]}}, "schema": []}
{"input": "The predicted Pay4p sequence contains two putative ATP-binding domains and shows structural relationships to other potential ATP-binding proteins involved in biological processes as diverse as peroxisome biogenesis, vesicle-mediated protein transport, cell cycle control, and transcriptional regulation.", "output": {"entities": {"gene": [{"text": "Pay4p sequence", "start": 14, "end": 28}, {"text": "ATP-binding proteins", "start": 125, "end": 145}]}}, "schema": []}
{"input": "The results show that the structure of the decorin gene promoter is different from that of any other proteoglycan promoter characterized so far and indicate that the pur/pyr segment plays a role in the regulation of gene transcription.", "output": {"entities": {"gene": [{"text": "decorin gene promoter", "start": 43, "end": 64}]}}, "schema": []}
{"input": "The kinase inhibitor staurosporine (1 microM) blocks LPA-induced, but not epidermal growth factor-induced, activation of p21ras and MAP kinase, consistent with an intermediate protein kinase linking the LPA receptor to p21ras activation.", "output": {"entities": {"gene": [{"text": "p21ras", "start": 121, "end": 127}, {"text": "MAP kinase", "start": 132, "end": 142}, {"text": "LPA receptor", "start": 203, "end": 215}, {"text": "p21ras", "start": 219, "end": 225}]}}, "schema": []}
{"input": "267, 4870-4877)) indicates an overall identity of 58 and 56%, respectively, with a 91 and 92% identity in the highly conserved transmembrane and cytoplasmic domains.", "output": {"entities": {}}, "schema": []}
{"input": "S., K.", "output": {"entities": {}}, "schema": []}
{"input": "The survival rate at forty months in 15 patients with N2 disease who underwent R2b operation was 51%.", "output": {"entities": {}}, "schema": []}
{"input": "Mothers with severe anatomical abnormalities, who are HIV positive, have active TB or whose children have inherited mono-or disaccharide intolerances should not breastfeed.", "output": {"entities": {}}, "schema": []}
{"input": "G.", "output": {"entities": {}}, "schema": []}
{"input": "The psaD, psaF, psaH, and psaL products have two isoforms each that are distinguished by different mobilities in polyacrylamide gel electrophoresis, and the psaE product has four isoforms.", "output": {"entities": {"gene": [{"text": "psaD", "start": 4, "end": 8}, {"text": "psaF", "start": 10, "end": 14}, {"text": "psaH", "start": 16, "end": 20}, {"text": "psaL products", "start": 26, "end": 39}, {"text": "psaE product", "start": 157, "end": 169}]}}, "schema": []}
{"input": "When Hy-Vac SPF type V embryos were exposed to either 0. 20 ml 50% ethanol in CRS or to 0. 20 ml CRS (controls), ethanol-treated embryos showed a VSD incidence of 34. 1% compared with a 3. 6% incidence in the controls (P = 0. 0017).", "output": {"entities": {}}, "schema": []}
{"input": "Peripheral vitreochorioretinal dystrophies in myopia patients", "output": {"entities": {}}, "schema": []}
{"input": "The secondary, but not the primary, antibody responses of male C57Bl/6 mice were higher among mice housed alone compared to mice housed in groups; differences were observed for both IgM and IgG anti-KLH antibodies.", "output": {"entities": {"gene": [{"text": "IgM", "start": 182, "end": 185}, {"text": "IgG anti-KLH antibodies", "start": 190, "end": 213}]}}, "schema": []}
{"input": "However, a surprisingly high degree of conservation of intron sequences was observed between both species.", "output": {"entities": {}}, "schema": []}
{"input": "Interleukin-6 may possibly potentiate metastasis of cardiac myxoma.", "output": {"entities": {"gene": [{"text": "Interleukin-6", "start": 0, "end": 13}]}}, "schema": []}
{"input": "Other parameters of iron metabolism, including ferritin, were not found to contribute to the risk.", "output": {"entities": {"gene": [{"text": "ferritin", "start": 47, "end": 55}]}}, "schema": []}
{"input": "Responses to the Plowright Rinderpest vaccine by 43 calves and 70 adult cattle in Uganda in 1990, through the production of IgG antibodies, were monitored for 4 weeks using the ELISA assay.", "output": {"entities": {"gene": [{"text": "IgG antibodies", "start": 124, "end": 138}]}}, "schema": []}
{"input": "Tumours of the cavum oris and oropharynx of T1-stage are possible only in 1 of 3 cases.", "output": {"entities": {}}, "schema": []}
{"input": "Thomas' Hospital solution (with 95% O2: 5% CO2) can meet the metabolic demand of the ischaemic myocardium and thus increase the safe duration of cardiac arrest.", "output": {"entities": {}}, "schema": []}
{"input": "Plasma, LDL and liver cholesterol concentrations were higher in the hyperlipidemic control than the nonhyperlipidemic control and lower in the groups fed diets containing pectin or prune fiber than in the hyperlipidemic control group.", "output": {"entities": {"gene": [{"text": "LDL", "start": 8, "end": 11}, {"text": "pectin", "start": 171, "end": 177}]}}, "schema": []}
{"input": "Routine psychometric screening of IHD patients may provide a cost-effective means of alerting cardiologists and internists to the relatively high levels of distress among their patients.", "output": {"entities": {}}, "schema": []}
{"input": "Employing this sequence information from c11/1, the c11/1-specific cDNA was generated from poly (A) + RNA of bovine PMNLs by reverse transcription and a combination of polymerase chain reaction (PCR) methods.", "output": {"entities": {}}, "schema": []}
{"input": "The deduced amino acid sequence of the mouse HO-1 gene is identical to that of p32, initially identified as a stress-induced protein in mouse BALBc/3T3 cells.", "output": {"entities": {"gene": [{"text": "mouse HO-1 gene", "start": 39, "end": 54}, {"text": "p32", "start": 79, "end": 82}]}}, "schema": []}
{"input": "Using a polymerase chain reaction-based approach, we cloned a 150-base pair fragment of a new sialymotif from human placenta mRNA, which was then used as a probe to clone the complete coding sequence of the corresponding gene from a cDNA library.", "output": {"entities": {}}, "schema": []}
{"input": "The structural analysis also demonstrated that the heterogeneity of the HDC mRNA is caused by an insertion of the seventh intron sequence and alternative use of the splicing acceptor site at the 12th exon.", "output": {"entities": {"gene": [{"text": "HDC mRNA", "start": 72, "end": 80}]}}, "schema": []}
{"input": "A complementary DNA was isolated from Caenorhabditis elegans that encoded a polypeptide of 1438 amino acid residues, CeGAP, which contains a domain with sequence similarity to the COOH-terminal segment (GTPase-activating protein region) of Bcr and other known GTPase-activating proteins of the Rho subfamily.", "output": {"entities": {"gene": [{"text": "CeGAP", "start": 117, "end": 122}, {"text": "COOH-terminal segment (GTPase-activating protein region)", "start": 180, "end": 236}, {"text": "Bcr", "start": 240, "end": 243}, {"text": "GTPase-activating proteins", "start": 260, "end": 286}, {"text": "Rho subfamily", "start": 294, "end": 307}]}}, "schema": []}
{"input": "Additional exonuclease III protection was observed beyond the core region on both the 5' and 3' sides, suggesting that E1 interacted with more distal sequences as well.", "output": {"entities": {"gene": [{"text": "exonuclease III", "start": 11, "end": 26}, {"text": "E1", "start": 119, "end": 121}]}}, "schema": []}
{"input": "Repression is alleviated when the two (for E2) or three (for E2-C) promoter-proximal copies of E2-RS are mutated.", "output": {"entities": {"gene": [{"text": "E2", "start": 43, "end": 45}, {"text": "E2-C", "start": 61, "end": 65}, {"text": "E2", "start": 95, "end": 97}]}}, "schema": []}
{"input": "A mutant in the AAV terminal resolution site (trs) was defective for DNA replication in the in vitro assay.", "output": {"entities": {}}, "schema": []}
{"input": "The results indicate that rep strongly enhances the function of negative regulatory elements of the LTR.", "output": {"entities": {"gene": [{"text": "rep", "start": 26, "end": 29}]}}, "schema": []}
{"input": "The Oct-3/4 gene product, which belongs to the POU family of transcription factors, is a good candidate for regulating initial differentiation decisions.", "output": {"entities": {"gene": [{"text": "Oct-3/4 gene product", "start": 4, "end": 24}, {"text": "POU family of transcription factors", "start": 47, "end": 82}]}}, "schema": []}
{"input": "Using site-directed mutagenesis, we show that the RAREoct contributes to the transcriptional activation of Oct-3/4 promoter in P19 cells and, most interestingly, mediates the RA-induced repression in RA-differentiated EC cells.", "output": {"entities": {"gene": [{"text": "RAREoct", "start": 50, "end": 57}, {"text": "Oct-3/4 promoter", "start": 107, "end": 123}]}}, "schema": []}
{"input": "176: 787-792, 1992; M.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, the negative transcriptional effect of COUP-TFs is dominant over the activating effect of the Oct4 embryonic stem cell-specific enhancer.", "output": {"entities": {"gene": [{"text": "COUP-TFs", "start": 52, "end": 60}, {"text": "Oct4 embryonic stem cell-specific enhancer", "start": 107, "end": 149}]}}, "schema": []}
{"input": "Analysis of mig/CAT chimeric constructs transiently transfected into the RAW 264. 7 mouse monocytic cell line revealed a unique IFN-gamma-responsive element (gamma RE-1).", "output": {"entities": {"gene": [{"text": "mig", "start": 12, "end": 15}, {"text": "CAT", "start": 16, "end": 19}, {"text": "IFN-gamma-responsive element", "start": 128, "end": 156}, {"text": "gamma RE-1", "start": 158, "end": 168}]}}, "schema": []}
{"input": "When expressed alone in test cells, Atr-I is unable to bind TGF-beta, activin, or bone morphogenetic protein 2.", "output": {"entities": {"gene": [{"text": "Atr-I", "start": 36, "end": 41}, {"text": "TGF-beta", "start": 60, "end": 68}, {"text": "activin", "start": 70, "end": 77}, {"text": "bone morphogenetic protein 2", "start": 82, "end": 110}]}}, "schema": []}
{"input": "Therefore, Mxi1 and Mad might antagonize Myc function and are candidate tumor suppressor genes.", "output": {"entities": {"gene": [{"text": "Mxi1", "start": 11, "end": 15}, {"text": "Mad", "start": 20, "end": 23}, {"text": "Myc", "start": 41, "end": 44}]}}, "schema": []}
{"input": "To our knowledge, type IV renal tubular acidosis has not been reported previously in association with Alport' s syndrome in an adult patient.", "output": {"entities": {}}, "schema": []}
{"input": "A cDNA clone was isolated from a chicken embryo cDNA library employing a PCR-generated radiolabeled probe specific for the U3 region of the Rous sarcoma virus LTR.", "output": {"entities": {"gene": [{"text": "U3 region", "start": 123, "end": 132}, {"text": "Rous sarcoma virus LTR", "start": 140, "end": 162}]}}, "schema": []}
{"input": "Two basic patterns of locomotor behavior and corresponding torso morphology exist among extant anthropoids.", "output": {"entities": {}}, "schema": []}
{"input": "Animal age and sex had no significant effects on CSF composition, but serum IgG concentration increased with age.", "output": {"entities": {"gene": [{"text": "IgG", "start": 76, "end": 79}]}}, "schema": []}
{"input": "Fast continuous expansion.", "output": {"entities": {}}, "schema": []}
{"input": "A randomized, multicenter study comparing the efficacy and tolerability of tropisetron, a new 5-HT3 receptor antagonist, with a metoclopramide-containing antiemetic cocktail in the prevention of cisplatin-induced emesis.", "output": {"entities": {"gene": [{"text": "5-HT3 receptor", "start": 94, "end": 108}]}}, "schema": []}
{"input": "Each repeat consists of 12 nt, coding for the reiterated sequence, K/NPAG.", "output": {"entities": {}}, "schema": []}
{"input": "BACKGROUND: To determine the predictors of desipramine-refractory depression, the authors examined the outcome in patients with major depression who were admitted to a general hospital and treated with desipramine adjusted to an adequate blood level.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of the intact hGH gene or hGH 5'-flanking DNA (5'-FR) coupled to the hGh cDNA or chloramphenicol acetyltransferase or luciferase genes, indicated that cAMP primarily stimulated hGH promoter activity.", "output": {"entities": {"gene": [{"text": "hGH gene", "start": 23, "end": 31}, {"text": "hGH 5'-flanking DNA (5'-FR)", "start": 35, "end": 62}, {"text": "hGh cDNA", "start": 78, "end": 86}, {"text": "chloramphenicol acetyltransferase", "start": 90, "end": 123}, {"text": "luciferase genes", "start": 127, "end": 143}, {"text": "hGH promoter", "start": 186, "end": 198}]}}, "schema": []}
{"input": "The predicted amino acid sequence of the SAP-1 cDNA showed that mature SAP-1 consisted of 1093 amino acids and a transmembrane-type PTP, which possessed a single PTP-conserved domain in the cytoplasmic region.", "output": {"entities": {"gene": [{"text": "SAP-1 cDNA", "start": 41, "end": 51}, {"text": "mature SAP-1", "start": 64, "end": 76}, {"text": "transmembrane-type PTP", "start": 113, "end": 135}, {"text": "PTP-conserved domain", "start": 162, "end": 182}]}}, "schema": []}
{"input": "Several features of 10. 24. 6 cells suggest that the mutation disrupts normal intracellular formation of peptide/DR complexes.", "output": {"entities": {"gene": [{"text": "peptide/DR complexes", "start": 105, "end": 125}]}}, "schema": []}
{"input": "This distribution parallels that of the neurotransmitters glutamate and aspartate; however, neither of these excitatory amino acids is a substrate for transport.", "output": {"entities": {}}, "schema": []}
{"input": "The Harleco apparatus is a simple, useful, cost-effective adjunct to the diagnosis and treatment of this life-threatening condition.", "output": {"entities": {}}, "schema": []}
{"input": "Co-transfection of expression vectors for CCAAT/enhancer binding protein (C/EBP) alpha and C/EBP beta trans-activated the rat uncoupling protein gene promoter due to sequences in the 5' proximal region.", "output": {"entities": {"gene": [{"text": "CCAAT/enhancer binding protein (C/EBP) alpha", "start": 42, "end": 86}, {"text": "C/EBP beta", "start": 91, "end": 101}, {"text": "rat uncoupling protein gene promoter", "start": 122, "end": 158}]}}, "schema": []}
{"input": "It was not possible to study the basis for tissue-specific expression of this gene, because the beta 3 gene promoter had not been isolated previously.", "output": {"entities": {"gene": [{"text": "beta 3 gene promoter", "start": 96, "end": 116}]}}, "schema": []}
{"input": "Isolation and characterization of a TATA-less promoter for the human beta 3 integrin gene.", "output": {"entities": {"gene": [{"text": "human beta 3 integrin gene", "start": 63, "end": 89}]}}, "schema": []}
{"input": "Subretinal fluid was punctured on the poorer eye in 19 eyes (52. 7%) and on the better eye in 7 eyes (19. 4%).", "output": {"entities": {}}, "schema": []}
{"input": "These data indicate that activation of these enzymes is not sufficient for the acute stimulation of glucose transport.", "output": {"entities": {}}, "schema": []}
{"input": "The inserted region, which represents an intron in brain and muscle, is expressed in the tumor cell lines either as a \" readthrough \" form or with 78 residues deleted from its 5' end.", "output": {"entities": {}}, "schema": []}
{"input": "Concordance of IBDQ scores was tested in 280 stable subjects.", "output": {"entities": {}}, "schema": []}
{"input": "Regression line slopes of IBDQ scores were significantly different in patients who deteriorated from those who remained stable ([b] < 0. 15; P < 0. 0001).", "output": {"entities": {}}, "schema": []}
{"input": "Inhibition of erythromycin synthesis by disruption of malonyl-coenzyme A decarboxylase gene eryM in Saccharopolyspora erythraea.", "output": {"entities": {"gene": [{"text": "malonyl-coenzyme A decarboxylase gene eryM", "start": 54, "end": 96}]}}, "schema": []}
{"input": "This region is required for activation of DNA binding of MyoD and E12 homodimers and E12/MyoD heterodimers.", "output": {"entities": {"gene": [{"text": "MyoD", "start": 57, "end": 61}, {"text": "E12 homodimers", "start": 66, "end": 80}, {"text": "E12", "start": 85, "end": 88}, {"text": "MyoD", "start": 89, "end": 93}]}}, "schema": []}
{"input": "Site-directed mutagenesis of the traI structural gene and application of purified mutant TraI proteins for in vitro assays served to evaluate the functional importance of conserved amino acid residues.", "output": {"entities": {"gene": [{"text": "traI structural gene", "start": 33, "end": 53}, {"text": "TraI proteins", "start": 89, "end": 102}]}}, "schema": []}
{"input": "Concerted action of three distinct domains in the DNA cleaving-joining reaction catalyzed by relaxase (TraI) of conjugative plasmid RP4.", "output": {"entities": {"gene": [{"text": "relaxase", "start": 93, "end": 101}, {"text": "TraI", "start": 103, "end": 107}]}}, "schema": []}
{"input": "The COOH-terminal 46 codons of slyD encode a remarkable histidine-rich peptide sequence which is at least partly dispensable for slyD function in E-mediated lysis.", "output": {"entities": {"gene": [{"text": "slyD", "start": 31, "end": 35}, {"text": "slyD", "start": 129, "end": 133}, {"text": "E", "start": 146, "end": 147}]}}, "schema": []}
{"input": "We studied GSH-Px enzyme activity in serum after acute myocardial infarction (AMI) and unstable angina pectoris (UAP).", "output": {"entities": {}}, "schema": []}
{"input": "The HGF-induced cell motility was mimicked by 12-0-tetradecanoyl-phorbol-13-acetate, a protein kinase C-activating phorbol ester, but not by Ca2 + ionophore.", "output": {"entities": {"gene": [{"text": "HGF", "start": 4, "end": 7}, {"text": "protein kinase C", "start": 87, "end": 103}]}}, "schema": []}
{"input": "In addition, lexical priming was examined by presenting an identity prime earlier in the text.", "output": {"entities": {}}, "schema": []}
{"input": "METHODS: Forty-nine cases with intrahepatic multiple nodules of HCC, by gross examination, among 184 consecutive resected HCCs were examined clinicopathologically.", "output": {"entities": {}}, "schema": []}
{"input": "In the present report, 66 hemochromatosis families yielding 151 hemochromatosis chromosomes and 182 normal chromosomes were RFLP-typed with a battery of probes, including two newly derived polymorphic markers from the 6. 7 and HLA-F loci located 150 and 250 kb telomeric to HLA-A, respectively.", "output": {"entities": {"gene": [{"text": "HLA-F loci", "start": 227, "end": 237}, {"text": "HLA-A", "start": 274, "end": 279}]}}, "schema": []}
{"input": "Pneumothorax during laparoscopic dissection of the diaphragmatic hiatus.", "output": {"entities": {}}, "schema": []}
{"input": "Different cortical malformations were produced in rats by a single dose of X-rays (200 cGy) given on different days during gestation.", "output": {"entities": {}}, "schema": []}
{"input": "T2 cancers should not be excluded from the benefit of preoperative irradiation.", "output": {"entities": {}}, "schema": []}
{"input": "IFN alpha and IFN gamma inducibility is mediated by a single element: a high affinity, nearly palindromic version of the IFN gamma activation site (GAS).", "output": {"entities": {"gene": [{"text": "IFN alpha", "start": 0, "end": 9}, {"text": "IFN gamma", "start": 14, "end": 23}, {"text": "IFN gamma activation site", "start": 121, "end": 146}, {"text": "GAS", "start": 148, "end": 151}]}}, "schema": []}
{"input": "Twenty-three sequence-tagged sites (STSs) were mapped within the contig, a density of approximately 1 per 200 kb.", "output": {"entities": {}}, "schema": []}
{"input": "In this paper, we demonstrate that binding of the GA-binding protein (GABP) to ets sequence motifs within each repeated unit is required for transcriptional activation of the COXIV promoter.", "output": {"entities": {"gene": [{"text": "GA-binding protein", "start": 50, "end": 68}, {"text": "GABP", "start": 70, "end": 74}, {"text": "ets sequence motifs", "start": 79, "end": 98}, {"text": "COXIV promoter", "start": 175, "end": 189}]}}, "schema": []}
{"input": "To gain further insight into the pathogenesis of the adult respiratory distress syndrome (ARDS), the authors studied possible relationships among the activation status of circulating polymorphonuclear neutrophils (PMN), cytokine levels, and the severity of lung injury in 31 patients: 15 with ARDS, 9 with severe pneumonia uncomplicated by ARDS, and 7 mechanically ventilated patients with neither ARDS nor pneumonia.", "output": {"entities": {}}, "schema": []}
{"input": "Amiodarone, seldom used as first-line treatment, appears to be the most effective drug.", "output": {"entities": {}}, "schema": []}
{"input": "These results demonstrate that dopamine receptor stimulation by different dopamine agonists produces a different pattern of effects on the characteristics of the reaction time response.", "output": {"entities": {"gene": [{"text": "dopamine receptor", "start": 31, "end": 48}]}}, "schema": []}
{"input": "Two experiments were conducted to study the vacuous jaw movements induced in rats by acute administration of the monoamine-depleting agent reserpine.", "output": {"entities": {}}, "schema": []}
{"input": "Depletion of dopamine in the nucleus accumbens led to a dramatic shift in behavior in which there was a significant decrease in lever pressing but a significant increase in consumption of lab chow.", "output": {"entities": {}}, "schema": []}
{"input": "We have investigated the influence of NaFe3 + EDTA, and of increasing dietary levels of Na2EDTA, on Zn, Cu and Ca metabolism in rats fed on Zn-sufficient and Zn-deficient soya-bean-isolate-based diets.", "output": {"entities": {}}, "schema": []}
{"input": "Recovery of carbimazole-induced agranulocytosis following recombinant granulocyte-macrophage colony stimulating factor (rhGM-CSF) administration.", "output": {"entities": {"gene": [{"text": "recombinant granulocyte-macrophage colony stimulating factor", "start": 58, "end": 118}, {"text": "rhGM-CSF", "start": 120, "end": 128}]}}, "schema": []}
{"input": "Thus, the system can be used to detect and study dynamic perfusion changes from the brain surface with minimal tissue damage.", "output": {"entities": {}}, "schema": []}
{"input": "The neglect of Richards' s theory demonstrates the range of factors, other than the strictly scientific, which can be important in determining the influence or otherwise of a psychological theory.", "output": {"entities": {}}, "schema": []}
{"input": "The positive-acting global sulfur regulatory protein, CYS3, of Neurospora crassa turns on the expression of a family of unlinked structural genes that encode enzymes of sulfur catabolism.", "output": {"entities": {"gene": [{"text": "CYS3", "start": 54, "end": 58}]}}, "schema": []}
{"input": "Analysis of the upstream untranslated region of CHL15 revealed the presence of the hexamer element, ACGCGT (an MluI restriction site) controlling both the periodic expression and coordinate regulation of the DNA synthesis genes in budding yeast.", "output": {"entities": {"gene": [{"text": "CHL15", "start": 48, "end": 53}, {"text": "MluI restriction site", "start": 111, "end": 132}]}}, "schema": []}
{"input": "The C-terminal region of the 150-kDa protein contains an NTP-binding helicase motif and the readthrough region, an RNA polymerase motif, indicating that these two overlapping proteins may form an RNA replication complex similar to those of tobamo-and tobraviruses.", "output": {"entities": {"gene": [{"text": "helicase motif", "start": 69, "end": 83}, {"text": "RNA polymerase motif", "start": 115, "end": 135}]}}, "schema": []}
{"input": "On T2 weighted images, low intensity areas in the thalamus, the striatum, the anterior limb of the internal capsule, the tegmentum of midbrain, high intensity areas in middle cerebellar peduncle, the posterior limb of the internal capsule, the lateral part of the cerebral peduncle, and the cerebral white matter were noted.", "output": {"entities": {}}, "schema": []}
{"input": "Using the rap1t alleles to generate wild-type cells differing only in telomere tract lengths, we also show that telomere position effects are highly sensitive to changes in the size (or structure) of the telomeric tract.", "output": {"entities": {"gene": [{"text": "rap1t alleles", "start": 10, "end": 23}]}}, "schema": []}
{"input": "Pronounced microangiopathy characterized by avascular fields, enlarged and tortuous capillaries and increased transcapillary diffusion of sodium fluorescein, was clearly demonstrable in the area of the nodules.", "output": {"entities": {}}, "schema": []}
{"input": "Epigenetic switching of transcriptional states: cis-and trans-acting factors affecting establishment of silencing at the HMR locus in Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "HMR locus", "start": 121, "end": 130}]}}, "schema": []}
{"input": "The two methods identify the same patients only if micturitional pressures are normal (40 to 60 cmH2O) to high (over 60 cmH2O) and the Sussett formula is used with a higher (95th centile) cutoff.", "output": {"entities": {}}, "schema": []}
{"input": "There was no clear correlation between the MFA and the severity of the UTS phenotype.", "output": {"entities": {}}, "schema": []}
{"input": "Chicken sterol carrier protein 2/sterol carrier protein x: cDNA cloning reveals evolutionary conservation of structure and regulated expression.", "output": {"entities": {"gene": [{"text": "sterol carrier protein 2", "start": 8, "end": 32}, {"text": "sterol carrier protein x", "start": 33, "end": 57}]}}, "schema": []}
{"input": "The plasmatic albumin concentration (3. 5-4. 5 g/dl) represents about 60% of the total plasma protein.", "output": {"entities": {"gene": [{"text": "plasmatic albumin", "start": 4, "end": 21}]}}, "schema": []}
{"input": "A single five minute period of rapid atrial pacing fails to limit infarct size in the in situ rabbit heart.", "output": {"entities": {}}, "schema": []}
{"input": "Neither RD19 nor RD21 mRNA synthesis was responsive to cold or to heat stress.", "output": {"entities": {"gene": [{"text": "RD19", "start": 8, "end": 12}, {"text": "RD21 mRNA", "start": 17, "end": 26}]}}, "schema": []}
{"input": "Previous studies indicated that the 20S proteasome is a catalytic core of the 26S proteolytic complex that possesses a latent multicatalytic proteinase activity and catalyzes an ATP-dependent, selective breakdown of proteins ligated to ubiquitin.", "output": {"entities": {"gene": [{"text": "20S proteasome", "start": 36, "end": 50}, {"text": "26S proteolytic complex", "start": 78, "end": 101}, {"text": "ubiquitin", "start": 236, "end": 245}]}}, "schema": []}
{"input": "The O2 deficit was not related to blood lactate during submaximal exercise, muscle enzyme activity (citrate synthase, 3-hydroxyacyl-CoA-dehydrogenase, lactate dehydrogenase), number of muscle capillaries,% ST fibres or muscle buffer capacity.", "output": {"entities": {"gene": [{"text": "citrate synthase", "start": 100, "end": 116}, {"text": "3-hydroxyacyl-CoA-dehydrogenase", "start": 118, "end": 149}, {"text": "lactate dehydrogenase", "start": 151, "end": 172}]}}, "schema": []}
{"input": "The sequence of the putative RBP1 protein contains two copies of an RNA recognition motif, two glutamine stretches, an asparagine-rich region, a methionine-rich region, and two long potential alpha-helixes.", "output": {"entities": {"gene": [{"text": "RBP1 protein", "start": 29, "end": 41}]}}, "schema": []}
{"input": "One defective RNA with a large deletion in the p70 coding region was able to replicate efficiently, both when inoculated with the helper genome and when inoculated with a second complementing defective RNA that supplied a wild-type p70.", "output": {"entities": {"gene": [{"text": "p70 coding region", "start": 47, "end": 64}, {"text": "wild-type p70", "start": 222, "end": 235}]}}, "schema": []}
{"input": "Complete nucleotide sequence of the bacteriophage K1F tail gene encoding endo-N-acylneuraminidase (endo-N) and comparison to an endo-N homolog in bacteriophage PK1E.", "output": {"entities": {"gene": [{"text": "bacteriophage K1F tail gene", "start": 36, "end": 63}, {"text": "endo-N-acylneuraminidase", "start": 73, "end": 97}, {"text": "endo-N", "start": 99, "end": 105}, {"text": "endo-N homolog", "start": 128, "end": 142}]}}, "schema": []}
{"input": "Binding of U2 small nuclear ribonucleoprotein was partially inhibited.", "output": {"entities": {"gene": [{"text": "U2 small nuclear ribonucleoprotein", "start": 11, "end": 45}]}}, "schema": []}
{"input": "Morphometrical quantification of brain edema related to experimental multiple micro-infarcts in mice: assessment of neurotropin effect.", "output": {"entities": {"gene": [{"text": "neurotropin", "start": 116, "end": 127}]}}, "schema": []}
{"input": "One member of this multigene family, GATA-3, is most abundantly expressed in T lymphocytes, a cellular target for human immunodeficiency virus type 1 (HIV-1) infection and replication.", "output": {"entities": {"gene": [{"text": "GATA-3", "start": 37, "end": 43}]}}, "schema": []}
{"input": "Indeed, significant level of CAT activity was observed in human lung adenocarcinoma (A549-1) cells which had been incubated with a complex of T7 RNA polymerase, pT7-EMC-CAT DNA and DC-chol cationic liposomes.", "output": {"entities": {"gene": [{"text": "CAT", "start": 29, "end": 32}, {"text": "T7 RNA polymerase", "start": 142, "end": 159}, {"text": "pT7-EMC-CAT DNA", "start": 161, "end": 176}]}}, "schema": []}
{"input": "Pneumoscrotum is a rare condition that receives little discussion in standard texts of urology.", "output": {"entities": {}}, "schema": []}
{"input": "The first gene codes for a protein containing 11 cystein residues in an arrangement typical for Fe/S proteins.", "output": {"entities": {"gene": [{"text": "Fe/S proteins", "start": 96, "end": 109}]}}, "schema": []}
{"input": "Triton-disrupted cells retained capacity for activation of the pathway by both peptide growth factors and by addition of GTP-loaded p21 rasVal12.", "output": {"entities": {"gene": [{"text": "p21 rasVal12", "start": 132, "end": 144}]}}, "schema": []}
{"input": "To begin to examine the mechanism controlling expression of this gene during the cell-cycle, a mouse B-myb 5' flanking sequence was isolated from a cosmid library and shown to promote efficiently the transcription of a luciferase reporter gene when transfected into NIH3T3 fibroblasts.", "output": {"entities": {"gene": [{"text": "mouse B-myb 5' flanking sequence", "start": 95, "end": 127}, {"text": "luciferase reporter gene", "start": 219, "end": 243}]}}, "schema": []}
{"input": "The influence of a high ionic strength on the resolution was clearly shown.", "output": {"entities": {}}, "schema": []}
{"input": "The number of bacteria in the lung, peripheral white blood cell and BAL fluid cell also decreased by the administration of FN.", "output": {"entities": {"gene": [{"text": "FN", "start": 123, "end": 125}]}}, "schema": []}
{"input": "In mice, three major families of L1 elements, termed \" A, \" \" F, \" and \" V, \" have been defined on the basis of the sequence found at the 5' terminus.", "output": {"entities": {}}, "schema": []}
{"input": "TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation.", "output": {"entities": {"gene": [{"text": "TFEC", "start": 0, "end": 4}, {"text": "basic helix-loop-helix protein", "start": 8, "end": 38}, {"text": "TFE3", "start": 64, "end": 68}, {"text": "TFE3", "start": 82, "end": 86}]}}, "schema": []}
{"input": "Similar results were seen on Western blots of Autographa californica MNPV (AcMNPV)-infected Spodoptera frugiperda cells.", "output": {"entities": {}}, "schema": []}
{"input": "In infected mammalian cells, the ARV G and GNS genes are transcribed primarily as a polycistronic mRNA which appears to extend from the consensus sequence (AACAG) at the start of the G gene to the next recognized polyadenylation signal (CATG [A] 7) located 697 nucleotides downstream of the GNS protein termination codon.", "output": {"entities": {"gene": [{"text": "ARV G", "start": 33, "end": 38}, {"text": "GNS genes", "start": 43, "end": 52}, {"text": "G gene", "start": 183, "end": 189}, {"text": "GNS protein", "start": 291, "end": 302}]}}, "schema": []}
{"input": "Molecular cloning and expression of RPE65, a novel retinal pigment epithelium-specific microsomal protein that is post-transcriptionally regulated in vitro.", "output": {"entities": {"gene": [{"text": "RPE65", "start": 36, "end": 41}]}}, "schema": []}
{"input": "The mean power (in mu W) required to produce the observed flow rate was estimated at each outflow pressure as the product of the flow rate and the pressure across the lymphatic vessel.", "output": {"entities": {}}, "schema": []}
{"input": "Although antisperm antibodies are associated with infertility, many hospital laboratories do not test for these antibodies.", "output": {"entities": {}}, "schema": []}
{"input": "PPD-specific IgG subclass responses were evident to all four IgG subclasses.", "output": {"entities": {"gene": [{"text": "PPD", "start": 0, "end": 3}, {"text": "IgG", "start": 13, "end": 16}, {"text": "IgG", "start": 61, "end": 64}]}}, "schema": []}
{"input": "Anterior body pattern in Drosophila is specified by the graded distribution of the bicoid protein (bcd), which activates subordinate genes in distinct anterior domains.", "output": {"entities": {"gene": [{"text": "bicoid protein", "start": 83, "end": 97}, {"text": "bcd", "start": 99, "end": 102}]}}, "schema": []}
{"input": "GAP-N bound constitutively to p190 in both serum-deprived and growth factor-stimulated cells.", "output": {"entities": {"gene": [{"text": "GAP-N", "start": 0, "end": 5}, {"text": "p190", "start": 30, "end": 34}]}}, "schema": []}
{"input": "The peptide sequence contains a region of 80 amino acids that shows similarity to bcl-2 and to the recently described bcl-2-related gene, MCL1.", "output": {"entities": {"gene": [{"text": "bcl-2", "start": 82, "end": 87}, {"text": "bcl-2-related gene", "start": 118, "end": 136}, {"text": "MCL1", "start": 138, "end": 142}]}}, "schema": []}
{"input": "The phosphorylation efficiency is improved by increasing the number of N-terminal arginine residues and by moving the arginyl cluster one residue further away from the serine, the nonapeptide (Arg) 4-Ala-Ala-Ser-Val-Ala being the best substrate among all the short peptides tested (Km = 15 microM).", "output": {"entities": {}}, "schema": []}
{"input": "The Saccharomyces cerevisiae GAL1 and GAL10 genes are controlled in response to the availability of galactose and glucose by multiple activating and repressing proteins bound at adjacent or overlapping sites in UASG.", "output": {"entities": {"gene": [{"text": "Saccharomyces cerevisiae GAL1", "start": 4, "end": 33}, {"text": "GAL10 genes", "start": 38, "end": 49}]}}, "schema": []}
{"input": "Surprisingly, the results of several experiments suggest that the TSF genes encode global regulatory factors. tsf1 to tsf6 mutations derepressed expression from yeast CYC-GAL hybrid promoters (fused to lacZ) that harbor a variety of operator sequences, and caused pleiotropic defects in cell growth, mating, and sporulation.", "output": {"entities": {"gene": [{"text": "TSF genes", "start": 66, "end": 75}, {"text": "tsf1", "start": 110, "end": 114}, {"text": "tsf6", "start": 118, "end": 122}, {"text": "CYC", "start": 167, "end": 170}, {"text": "GAL", "start": 171, "end": 174}, {"text": "lacZ", "start": 202, "end": 206}]}}, "schema": []}
{"input": "Sex of calf (variate 2) was associated most closely with width of muzzle and head.", "output": {"entities": {}}, "schema": []}
{"input": "Sequence comparison indicates that exons 5'/L and L/N in PSG12 and PSG12 psi are 99% identical, except that the L/N exon in the PSG12 psi gene contains a stop codon.", "output": {"entities": {"gene": [{"text": "PSG12", "start": 57, "end": 62}, {"text": "PSG12 psi", "start": 67, "end": 76}, {"text": "PSG12 psi gene", "start": 128, "end": 142}]}}, "schema": []}
{"input": "The mechanisms that govern the activation or suppression of the CD8 gene are likely to be central to the T cell development program.", "output": {"entities": {"gene": [{"text": "CD8 gene", "start": 64, "end": 72}]}}, "schema": []}
{"input": "We suggest that the ER lumenal variable domain of gp19K has a specific tertiary structure that is important for binding to the polymorphic alpha 1 and alpha 2 domains of class I heavy (alpha) chains.", "output": {"entities": {"gene": [{"text": "gp19K", "start": 50, "end": 55}, {"text": "class I heavy (alpha) chains", "start": 170, "end": 198}]}}, "schema": []}
{"input": "We recently found that 17 beta-estradiol (E2) not only suppresses bone resorption but also stimulates bone formation in the cancellous bone of female rats.", "output": {"entities": {}}, "schema": []}
{"input": "Recombinant human erythropoietin (epoetin) is approved to be administered by the intravenous (i. v.) or subcutaneous (SC) route.", "output": {"entities": {"gene": [{"text": "Recombinant human erythropoietin", "start": 0, "end": 32}, {"text": "epoetin", "start": 34, "end": 41}]}}, "schema": []}
{"input": "Single-photon emission computed tomography (SPECT) with 99mTc-hexamethylpropyleneamine oxime (HMPAO) was used to investigate changes in cerebral blood flow in seven patients with cortical visual impairment.", "output": {"entities": {}}, "schema": []}
{"input": "The rCBF ratio was mainly reduced in frontal lobes (65%).", "output": {"entities": {}}, "schema": []}
{"input": "METHODS: Twenty-two patients were grouped according to their etiology based on the study of antiadrenal antibodies at diagnosis of the disease: 7 were positive (autoimmune etiology or EAA), 11 were negative (tuberculous etiology or EAT) and in four serologic study was not available (undetermined etiology or EAI).", "output": {"entities": {}}, "schema": []}
{"input": "The UV induction of c-jun is mediated by two UV response elements consisting of AP-1-like sequences within its 5' control region.", "output": {"entities": {"gene": [{"text": "c-jun", "start": 20, "end": 25}, {"text": "AP-1-like sequences", "start": 80, "end": 99}]}}, "schema": []}
{"input": "Protein tyrosine phosphatases (PTPs), together with protein tyrosine kinases (PTKs), are involved in the regulation of cell activation, growth, and differentiation.", "output": {"entities": {"gene": [{"text": "Protein tyrosine phosphatases", "start": 0, "end": 29}, {"text": "PTPs", "start": 31, "end": 35}, {"text": "protein tyrosine kinases", "start": 52, "end": 76}, {"text": "PTKs", "start": 78, "end": 82}]}}, "schema": []}
{"input": "ST elevation occurs in 5 patients (55. 5%) of subgroup A and in no patient of the subgroup B.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, a p21X protein lacking the N-terminus of Rex1 was expressed at high levels; our data indicate that p21X is translated from the 1. 6-kb mRNA which is derived primarily from deleted proviruses.", "output": {"entities": {"gene": [{"text": "p21X protein", "start": 15, "end": 27}, {"text": "Rex1", "start": 54, "end": 58}, {"text": "p21X", "start": 112, "end": 116}]}}, "schema": []}
{"input": "HTLV-1 gene expression by defective proviruses in an infected T-cell line.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, it was confirmed that the sodium lauryl sulfate method of estimating hemoglobin concentration is an appropriate alternative to the cyanmethemoglobin method and avoids the generation of toxic wastes.", "output": {"entities": {"gene": [{"text": "hemoglobin", "start": 75, "end": 85}, {"text": "cyanmethemoglobin", "start": 137, "end": 154}]}}, "schema": []}
{"input": "A comparison of the predicted amino acid sequences of the two human PKC-delta clones with the rat and mouse homologues indicated a greater degree of sequence divergence (89-90% homology) compared to the high degree of sequence conservation observed with other human PKC family members and their mammalian counterparts.", "output": {"entities": {"gene": [{"text": "human PKC-delta", "start": 62, "end": 77}, {"text": "human PKC family members", "start": 260, "end": 284}]}}, "schema": []}
{"input": "XII.", "output": {"entities": {}}, "schema": []}
{"input": "When comparing the barley PSI-K and PSI-G with the reported PSI-K sequence from Synechococcus vulcanus, the degree of similarity is equal, suggesting that an ancestral gene has been duplicated in a chloroplast progenitor but not in a cyanobacterial.", "output": {"entities": {"gene": [{"text": "barley PSI-K", "start": 19, "end": 31}, {"text": "PSI-G", "start": 36, "end": 41}, {"text": "PSI-K sequence from Synechococcus vulcanus", "start": 60, "end": 102}]}}, "schema": []}
{"input": "Under these conditions, transfections with cDNAs of the NF-kappa B p50 and serum response factor (SRF) produced a factor (s) that mediated Tax binding to the NF-kappa B site and the CArG box respectively.", "output": {"entities": {"gene": [{"text": "NF-kappa B p50", "start": 56, "end": 70}, {"text": "serum response factor", "start": 75, "end": 96}, {"text": "SRF", "start": 98, "end": 101}, {"text": "Tax", "start": 139, "end": 142}, {"text": "NF-kappa B site", "start": 158, "end": 173}]}}, "schema": []}
{"input": "We show here that v-Rel specifically increased expression from a reporter plasmid containing multiple Sp1 binding sites approximately sixfold in chicken embryo fibroblasts (CEFs), even though v-Rel did not bind directly to these sites. v-Rel also increased expression from a reporter plasmid containing a human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) in which the kappa B binding sites were mutated but which still contained intact Sp1 binding sites.", "output": {"entities": {"gene": [{"text": "v-Rel", "start": 18, "end": 23}, {"text": "Sp1 binding sites", "start": 102, "end": 119}, {"text": "v-Rel", "start": 192, "end": 197}, {"text": "v-Rel", "start": 236, "end": 241}, {"text": "human immunodeficiency virus type 1 (HIV-1) long terminal repeat", "start": 305, "end": 369}, {"text": "kappa B binding sites", "start": 389, "end": 410}, {"text": "Sp1 binding sites", "start": 457, "end": 474}]}}, "schema": []}
{"input": "The simultaneous recording of electrical activity from the surface electrocardiogram, right ventricular apex, His bundle, high right atrium, coronary sinus, with or without a roving mapping catheter, enables us to precisely map the electrical activation sequence in the heart.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSION: This retrospective analysis does not confirm the efficacy of one course of simultaneous Mitomycin-C and 5-fluorouracil, at least in association with full-dose radiotherapy incorporating Iridium-192 boost.", "output": {"entities": {}}, "schema": []}
{"input": "Despite the existence of 30 cysteine residues, carboxymethylation prevented the formation of most if not all disulfide bonds that otherwise occurred when the cells were sonicated.", "output": {"entities": {}}, "schema": []}
{"input": "Cerebro-oculo-facioskeletal syndrome (Pena-Shokeir syndrome II)", "output": {"entities": {}}, "schema": []}
{"input": "Most importantly, the addition of purified 17S U2 snRNPs, but not of 12S U2 snRNPs, to HeLa splicing extracts in which the endogeneous U2 snRNPs have been functionally neutralized with anti-PRP9 antibodies fully restores the mRNA-splicing activity of the extracts.", "output": {"entities": {"gene": [{"text": "17S U2 snRNPs", "start": 43, "end": 56}, {"text": "12S U2 snRNPs", "start": 69, "end": 82}, {"text": "endogeneous U2 snRNPs", "start": 123, "end": 144}, {"text": "anti-PRP9 antibodies", "start": 185, "end": 205}]}}, "schema": []}
{"input": "Differences in profiles of viscosity variables between subgroups of EAD in RA patients were observed.", "output": {"entities": {}}, "schema": []}
{"input": "These contain a single 1977-bp exon that encodes 900 bp of the 5' and 3' untranslated sequences in addition to a 1077-bp open reading frame identical to that found in vascular smooth muscle cell AT1a receptor cDNAs.", "output": {"entities": {"gene": [{"text": "vascular smooth muscle cell AT1a receptor cDNAs", "start": 167, "end": 214}]}}, "schema": []}
{"input": "Deletion of a 53-bp early promoter region containing the transcription start site and a putative TATA box completely abolishes the ability of upstream elements to drive transcription of the luciferase cDNA.", "output": {"entities": {"gene": [{"text": "luciferase cDNA", "start": 190, "end": 205}]}}, "schema": []}
{"input": "One chimpanzee reliably selected the larger numeral 4 during testing with a nonadjacent pair (2-4), and 2 chimps showed no preference.", "output": {"entities": {}}, "schema": []}
{"input": "Dissipation of claudication pain after walking: implications for endurance training.", "output": {"entities": {}}, "schema": []}
{"input": "Alternative transcript of the nonselective-type endothelin receptor from rat brain.", "output": {"entities": {"gene": [{"text": "endothelin receptor", "start": 48, "end": 67}]}}, "schema": []}
{"input": "The Drosophila clathrin heavy chain gene: clathrin function is essential in a multicellular organism.", "output": {"entities": {"gene": [{"text": "clathrin heavy chain", "start": 15, "end": 35}, {"text": "clathrin", "start": 42, "end": 50}]}}, "schema": []}
{"input": "The binding specificity of this protein was compared to that of human E2F using a number of mutant E2F sites as competitors.", "output": {"entities": {"gene": [{"text": "human E2F", "start": 64, "end": 73}, {"text": "mutant E2F sites", "start": 92, "end": 108}]}}, "schema": []}
{"input": "To analyze the VH regions of polyreactive antibodies, with particular attention at their somatically mutated status, we generated five IgG (three IgG1 and two IgG3) mAb (using B cells from a healthy subject, a patient with insulin-dependent diabetes mellitus and a patient with SLE), which bound with various efficiencies a number of different self and foreign Ag.", "output": {"entities": {"gene": [{"text": "IgG", "start": 135, "end": 138}, {"text": "IgG1", "start": 146, "end": 150}, {"text": "IgG3", "start": 159, "end": 163}, {"text": "insulin", "start": 223, "end": 230}]}}, "schema": []}
{"input": "It is possible that the patch determines the proper conformation of the site and thereby contributes to recognition indirectly.", "output": {"entities": {}}, "schema": []}
{"input": "The 7-kb mRNA differs by alternative splicing such that it encodes a protein with a distinct amino terminus.", "output": {"entities": {}}, "schema": []}
{"input": "Kinetics of the inhibition indicated that this polymerase domain can inhibit viral replication only during the preinitiation stage.", "output": {"entities": {}}, "schema": []}
{"input": "3.", "output": {"entities": {}}, "schema": []}
{"input": "McCann III, F.", "output": {"entities": {}}, "schema": []}
{"input": "In order to investigate to what extent this interaction might contribute to tumor induction by the virus, we have introduced two different point mutations within the putative pRb-binding sequence of large T antigen, and as a preliminary to in vivo experiments we have studied their effects in vitro on some biological activities relevant to tumor induction.", "output": {"entities": {"gene": [{"text": "pRb-binding sequence", "start": 175, "end": 195}, {"text": "large T antigen", "start": 199, "end": 214}]}}, "schema": []}
{"input": "We conclude that the conservation of nucleotides 154 to 156 is likely to be a consequence of their role as a sequence-specific recognition element for the SRP54 protein.", "output": {"entities": {"gene": [{"text": "SRP54 protein", "start": 155, "end": 168}]}}, "schema": []}
{"input": "A region of the deduced protein shares extensive homology with a catalytic region of Raf kinases, a feature shared only with TFIIE among transcription factors.", "output": {"entities": {"gene": [{"text": "Raf kinases", "start": 85, "end": 96}, {"text": "TFIIE", "start": 125, "end": 130}]}}, "schema": []}
{"input": "The low molecular mass polypeptide complex is assumed to be involved in antigen presentation, generating peptides from cytosolic protein antigens, which are subsequently presented to cytotoxic T-lymphocytes on the cell surface.", "output": {"entities": {}}, "schema": []}
{"input": "Secondary cleavage of RT at Trp-595-Tyr-596 of Pol yields a truncated form lacking the C-terminal RNase H domain.", "output": {"entities": {"gene": [{"text": "RT", "start": 22, "end": 24}, {"text": "Pol", "start": 47, "end": 50}, {"text": "C-terminal RNase H domain", "start": 87, "end": 112}]}}, "schema": []}
{"input": "The C-terminal approximately 50 amino acids of Bel-1 are shown to be essential for Bel-1 activity but can be effectively substituted by the C-terminal activation domain of VP16.", "output": {"entities": {"gene": [{"text": "Bel-1", "start": 47, "end": 52}, {"text": "Bel-1", "start": 83, "end": 88}, {"text": "VP16", "start": 172, "end": 176}]}}, "schema": []}
{"input": "Since the-172/-148 element also conferred estrogen and thyroid hormone responsiveness, it can be considered a composite hormone response element.", "output": {"entities": {}}, "schema": []}
{"input": "Optimal activation of T cells requires at least two signals.", "output": {"entities": {}}, "schema": []}
{"input": "Together with a considerably shortened and interrupted aromatic aa stretch in this region, these differences are discussed in terms of the peculiar affinity of cyanobacterial cytochrome oxidases for acidic c-type cytochromes.", "output": {"entities": {"gene": [{"text": "cyanobacterial cytochrome oxidases", "start": 160, "end": 194}, {"text": "c-type cytochromes", "start": 206, "end": 224}]}}, "schema": []}
{"input": "All four of the genes have a similar structure, with the receptor protein encoded in a single exon.", "output": {"entities": {}}, "schema": []}
{"input": "Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters.", "output": {"entities": {"gene": [{"text": "GABP", "start": 12, "end": 16}, {"text": "NRF-2", "start": 22, "end": 27}, {"text": "cytochrome oxidase", "start": 57, "end": 75}, {"text": "ETS domain", "start": 119, "end": 129}]}}, "schema": []}
{"input": "The intracellular basic region/helix-loop-helix (bHLH) dioxin receptor mediates signal transduction by dioxin (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin) and functions as a ligand-activated DNA binding protein directly interacting with target genes by binding to dioxin response elements.", "output": {"entities": {"gene": [{"text": "basic region/helix-loop-helix (bHLH) dioxin receptor", "start": 18, "end": 70}]}}, "schema": []}
{"input": "The alpha 2A-adrenergic receptor (alpha 2AAR) is coupled to a variety of effectors via pertussis toxin-sensitive GTP-binding proteins.", "output": {"entities": {"gene": [{"text": "alpha 2A-adrenergic receptor", "start": 4, "end": 32}, {"text": "alpha 2AAR", "start": 34, "end": 44}, {"text": "pertussis toxin", "start": 87, "end": 102}, {"text": "GTP-binding proteins", "start": 113, "end": 133}]}}, "schema": []}
{"input": "A sequence comparison reveals two CCAAT/enhancer binding protein (C/EBP) consensus sequences, basic DNA binding region and leucine zippers 1 and 2 (bZIP1 and bZIP2), within this region.", "output": {"entities": {"gene": [{"text": "CCAAT/enhancer binding protein", "start": 34, "end": 64}, {"text": "C/EBP", "start": 66, "end": 71}]}}, "schema": []}
{"input": "One of these genes, REC114, is described here, and the data confirm that REC114 is a meiosis-specific recombination gene with no detectable function in mitosis.", "output": {"entities": {"gene": [{"text": "REC114", "start": 20, "end": 26}, {"text": "REC114", "start": 73, "end": 79}]}}, "schema": []}
{"input": "The transactivation function of EBNA2 was also observed in the HeLa epithelial cell line, which suggests that EBV and HIV-1 infection of non-B cells may result in HIV-1 promoter activation.", "output": {"entities": {"gene": [{"text": "EBNA2", "start": 32, "end": 37}, {"text": "HIV-1 promoter", "start": 163, "end": 177}]}}, "schema": []}
{"input": "Mutation of the C/EBP binding sites in the Rous sarcoma virus long terminal repeat and gag enhancers.", "output": {"entities": {"gene": [{"text": "C/EBP binding sites", "start": 16, "end": 35}, {"text": "Rous sarcoma virus long terminal repeat", "start": 43, "end": 82}, {"text": "gag enhancers", "start": 87, "end": 100}]}}, "schema": []}
{"input": "Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation.", "output": {"entities": {"gene": [{"text": "Nuclear protein phosphatase 2A", "start": 0, "end": 30}, {"text": "protein kinase A", "start": 48, "end": 64}, {"text": "CREB", "start": 80, "end": 84}, {"text": "CREB", "start": 99, "end": 103}]}}, "schema": []}
{"input": "We show that IL-6 activates JRE-IL6 through an H7-sensitive pathway that does not involve protein kinase C, cyclic AMP-dependent kinase, Ca (2 +)-or calmodulin-dependent kinases, Ras, Raf-1, or NF-IL6 (C/EBP beta).", "output": {"entities": {"gene": [{"text": "IL-6", "start": 13, "end": 17}, {"text": "JRE-IL6", "start": 28, "end": 35}, {"text": "protein kinase C", "start": 90, "end": 106}, {"text": "cyclic AMP-dependent kinase", "start": 108, "end": 135}, {"text": "Ca (2 +)-or calmodulin-dependent kinases", "start": 137, "end": 177}, {"text": "Ras", "start": 179, "end": 182}, {"text": "Raf-1", "start": 184, "end": 189}, {"text": "NF-IL6", "start": 194, "end": 200}, {"text": "C/EBP beta", "start": 202, "end": 212}]}}, "schema": []}
{"input": "Mutation of the presumptive phosphorylated tyrosine and threonine residues of Mpk1p individually to phenylalanine and alanine, respectively, severely impaired Mpk1p function.", "output": {"entities": {"gene": [{"text": "Mpk1p", "start": 78, "end": 83}, {"text": "Mpk1p", "start": 159, "end": 164}]}}, "schema": []}
{"input": "Growth factor stimulation rapidly induces a reversible change in the electrophoretic mobility of the ternary complex, accompanied by increased phosphorylation of the Elk-1 C-terminal region and by the activation of a 42 kd cellular Elk-1 kinase.", "output": {"entities": {"gene": [{"text": "Elk-1 C-terminal region", "start": 166, "end": 189}, {"text": "42 kd cellular Elk-1 kinase", "start": 217, "end": 244}]}}, "schema": []}
{"input": "In contrast to the situation in mammalian cells, prolonged exposure of the agonist (24 h) does not result in down regulation of the remaining 70% of the receptors.", "output": {"entities": {}}, "schema": []}
{"input": "This stimulatory effect could also be elicited by c-Jun, which interacts with topo II, but not by c-Fos, which does not bind topo II in our in vitro assay.", "output": {"entities": {"gene": [{"text": "c-Jun", "start": 50, "end": 55}, {"text": "topo II", "start": 78, "end": 85}, {"text": "c-Fos", "start": 98, "end": 103}, {"text": "topo II", "start": 125, "end": 132}]}}, "schema": []}
{"input": "The regulation of Myf-5 and MyoD function by a cAMP-dependent pathway may partly explain how external signals generated by serum and certain peptide growth factors can be transduced to the nucleus and inhibit dominant-acting factors that are responsible for myoblast differentiation.", "output": {"entities": {"gene": [{"text": "Myf-5", "start": 18, "end": 23}, {"text": "MyoD", "start": 28, "end": 32}]}}, "schema": []}
{"input": "16, 99-104).", "output": {"entities": {}}, "schema": []}
{"input": "We have previously reported that high level human desmin expression depends on a 280-base pair muscle-specific enhancer which can function not only in myotubes, but can also activate gene expression in myoblasts.", "output": {"entities": {"gene": [{"text": "human desmin", "start": 44, "end": 56}]}}, "schema": []}
{"input": "After surgery, patients self administered one of three possible postsurgical medications, which included placebo, codeine 60 mg, and ibuprofen 400 mg, when their pain reached a moderate or severe intensity.", "output": {"entities": {}}, "schema": []}
{"input": "Replacement of the wild-type 5'-regulatory region with either of the mutants' cis-acting regulatory element resulted in the anaerobic expression of active Mn-superoxide dismutase.", "output": {"entities": {"gene": [{"text": "active Mn-superoxide dismutase", "start": 148, "end": 178}]}}, "schema": []}
{"input": "The orf61 gene product, when expressed from an exogenous promoter, inhibited int-mediated integration at the chromosomal attB site.", "output": {"entities": {"gene": [{"text": "orf61 gene product", "start": 4, "end": 22}, {"text": "int", "start": 77, "end": 80}, {"text": "chromosomal attB site", "start": 109, "end": 130}]}}, "schema": []}
{"input": "Expression in established LCLs, occurring irrespective of virus producer status, was not a consequence of continued in vitro passage; thus, appropriately spliced BamHI-A transcripts could be amplified from normal B cells within 1 day of their experimental infection in vitro, along with BamHI-C/W promoter-initiated but not BamHI-F promoter-initiated mRNAs.", "output": {"entities": {"gene": [{"text": "BamHI-A transcripts", "start": 162, "end": 181}, {"text": "BamHI-C/W", "start": 287, "end": 296}, {"text": "BamHI-F promoter-initiated mRNAs", "start": 324, "end": 356}]}}, "schema": []}
{"input": "Analysis by cell surface immunofluorescence showed that the UL28 gene is not required for expression of viral glycoproteins on the surface of infected cells.", "output": {"entities": {"gene": [{"text": "UL28 gene", "start": 60, "end": 69}]}}, "schema": []}
{"input": "Furthermore, a mutant receptor (Y977F/Y989F [PLC gamma-binding sites]) could fully activate Ras, and the direct activation of protein kinase C and calcium mobilization had almost no effect on the GDP/GTP state of Ras in this cell line.", "output": {"entities": {"gene": [{"text": "PLC gamma", "start": 45, "end": 54}, {"text": "Ras", "start": 92, "end": 95}, {"text": "protein kinase C", "start": 126, "end": 142}, {"text": "Ras", "start": 213, "end": 216}]}}, "schema": []}
{"input": "Estrogen treatment in high doses is effective in reducing adult stature in constitutionally tall girls.", "output": {"entities": {}}, "schema": []}
{"input": "Uracil DNA glycosylase catalyzes the initial step in the repair pathway that removes potentially mutagenic uracil from duplex DNA.", "output": {"entities": {"gene": [{"text": "Uracil DNA glycosylase", "start": 0, "end": 22}]}}, "schema": []}
{"input": "Current clinical trials should answer the question of which of the therapeutic options impairs quality of life less.", "output": {"entities": {}}, "schema": []}
{"input": "In this report, we focus on the genetics of the region of the 17 hep syn gB gene that conferred both the syncytial and pathogenic phenotypes to 17 syn +.", "output": {"entities": {"gene": [{"text": "17 hep syn gB gene", "start": 62, "end": 80}, {"text": "17 syn +", "start": 144, "end": 152}]}}, "schema": []}
{"input": "Recipients with acute leukaemia in first remission or chronic myeloid leukaemia in first chronic phase were analysed as good risk, and those beyond these stages, as poor risk patients.", "output": {"entities": {}}, "schema": []}
{"input": "Elledge, P.", "output": {"entities": {}}, "schema": []}
{"input": "Drugs suppressed > or = 75% of the total premature ventricular contractions in all patients who had both use-dependent QRS prolongation and reverse use-dependent QT prolongation, in 79% of patients with use-dependent QRS prolongation alone, in 70% with reverse use-dependent QT prolongation alone, and in 11% with neither use-dependent QRS prolongation nor reverse use-dependent QT prolongation.", "output": {"entities": {}}, "schema": []}
{"input": "Losses during the complete procedure are corrected for using radioactive estrogen conjugates during the first steps and later by adding deuterated internal standards of all compounds measured (matairesinol, enterodiol, enterolactone, daidzein, O-desmethylangolensin, equol, and genistein).", "output": {"entities": {}}, "schema": []}
{"input": "The Sp1 region, however, is converted to a functionally strong TRE by the viral tat factor.", "output": {"entities": {"gene": [{"text": "Sp1 region", "start": 4, "end": 14}, {"text": "viral tat factor", "start": 74, "end": 90}]}}, "schema": []}
{"input": "Three group 1 patients developed CMV disease; 1 group 2 patient developed CMV hepatitis.", "output": {"entities": {}}, "schema": []}
{"input": "The ability of spt2 mutations to suppress the transcriptional interference caused by the delta promoter insertion his-4-912 delta correlates with an increase in wild-type HIS4 mRNA levels.", "output": {"entities": {"gene": [{"text": "spt2 mutations", "start": 15, "end": 29}, {"text": "delta promoter insertion his-4-912 delta", "start": 89, "end": 129}, {"text": "wild-type HIS4 mRNA", "start": 161, "end": 180}]}}, "schema": []}
{"input": "Nuclear localization and protein sequence similarities suggested that the SPT2/SIN1 protein may be related to the nonhistone chromosomal protein HMG1.", "output": {"entities": {"gene": [{"text": "SPT2", "start": 74, "end": 78}, {"text": "SIN1", "start": 79, "end": 83}, {"text": "nonhistone chromosomal protein HMG1", "start": 114, "end": 149}]}}, "schema": []}
{"input": "The conserved ninth C-terminal heptad in thyroid hormone and retinoic acid receptors mediates diverse responses by affecting heterodimer but not homodimer formation.", "output": {"entities": {"gene": [{"text": "retinoic acid receptors", "start": 61, "end": 84}]}}, "schema": []}
{"input": "Genetic interactions between BCK2 and other pathway components suggested that BCK2 functions on a common pathway branch with PPZ1 and PPZ2.", "output": {"entities": {"gene": [{"text": "BCK2", "start": 29, "end": 33}, {"text": "BCK2", "start": 78, "end": 82}, {"text": "PPZ1", "start": 125, "end": 129}, {"text": "PPZ2", "start": 134, "end": 138}]}}, "schema": []}
{"input": "Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues.", "output": {"entities": {"gene": [{"text": "Steroidogenic factor 1", "start": 0, "end": 22}, {"text": "orphan nuclear receptor", "start": 27, "end": 50}, {"text": "rat aromatase gene", "start": 84, "end": 102}]}}, "schema": []}
{"input": "To study the functional differences between cutaneous HPV5 and HPV8 E7s and genital HPV16 E7, we cloned each of the E7 open reading frames and tested their immortalizing and transforming activities, the binding ability of their products with retinoblastoma protein (RB) and their complementation activity of a RB-nonbinding adenovirus E1A mutant.", "output": {"entities": {"gene": [{"text": "E7s", "start": 68, "end": 71}, {"text": "genital HPV16 E7", "start": 76, "end": 92}, {"text": "E7", "start": 116, "end": 118}, {"text": "retinoblastoma protein", "start": 242, "end": 264}, {"text": "RB", "start": 266, "end": 268}, {"text": "RB-nonbinding adenovirus E1A mutant", "start": 310, "end": 345}]}}, "schema": []}
{"input": "The rhaB transcription start site was mapped to-24 relative to the start of translation.", "output": {"entities": {"gene": [{"text": "rhaB transcription start site", "start": 4, "end": 33}]}}, "schema": []}
{"input": "Several lines of evidence demonstrate that this growth inhibition requires active PKA subunits and cAMP: (i) this phenotype is dependent on cAMP since it is not seen in a strain lacking adenylyl cyclase activity, but the growth rate of these transformants is slower when exogenous cAMP is added; (ii) normal growth occurs when wild-type RI cDNA is replaced by a mutant RI cDNA encoding a RI protein with reduced cAMP binding; and (iii) the growth-inhibited phenotype of the transformed BL21 (DE3) cells requires soluble, active C alpha protein.", "output": {"entities": {"gene": [{"text": "PKA subunits", "start": 82, "end": 94}, {"text": "adenylyl cyclase", "start": 186, "end": 202}, {"text": "RI", "start": 337, "end": 339}, {"text": "mutant RI cDNA", "start": 362, "end": 376}, {"text": "RI protein", "start": 388, "end": 398}, {"text": "C alpha protein", "start": 528, "end": 543}]}}, "schema": []}
{"input": "Liu, B.", "output": {"entities": {}}, "schema": []}
{"input": "BCR-ABL and v-abl oncogenes induce distinct patterns of thymic lymphoma involving different lymphocyte subsets.", "output": {"entities": {"gene": [{"text": "BCR", "start": 0, "end": 3}, {"text": "ABL", "start": 4, "end": 7}, {"text": "v-abl oncogenes", "start": 12, "end": 27}]}}, "schema": []}
{"input": "These experiments confirm that the 6-S liganded form of the receptor identified in nuclear extracts of cells treated with 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) contains the Ah receptor protein and ARNT but not the 90-kDa heat shock protein.", "output": {"entities": {"gene": [{"text": "Ah receptor protein", "start": 181, "end": 200}, {"text": "ARNT", "start": 205, "end": 209}, {"text": "90-kDa heat shock protein", "start": 222, "end": 247}]}}, "schema": []}
{"input": "LDL cholesterol decreased from 4. 74 +/-0. 87 to 3. 78 +/-0. 78 mmol/l after 8 weeks on simvastatin (P < 0. 001), and apo B fell from 142 +/-31 to 112 +/-22 mg/dl (P < 0. 001).", "output": {"entities": {"gene": [{"text": "LDL cholesterol", "start": 0, "end": 15}, {"text": "apo B", "start": 118, "end": 123}]}}, "schema": []}
{"input": "LDL cholesterol decreased from 4. 74 +/-0. 87 to 3. 78 +/-0. 78 mmol/l after 8 weeks on simvastatin (P < 0. 001), and apo B fell from 142 +/-31 to 112 +/-22 mg/dl (P < 0. 001).", "output": {"entities": {"gene": [{"text": "LDL cholesterol", "start": 0, "end": 15}, {"text": "apo B", "start": 118, "end": 123}]}}, "schema": []}
{"input": "This negative element may, at least in part, be responsible for the cell type-specific expression of the DGK gene.", "output": {"entities": {"gene": [{"text": "DGK gene", "start": 105, "end": 113}]}}, "schema": []}
{"input": "Regulated activity of the distal promoter-like element of the human corticotropin-releasing hormone gene and secondary structural features of its corresponding transcripts.", "output": {"entities": {"gene": [{"text": "human corticotropin-releasing hormone gene", "start": 62, "end": 104}]}}, "schema": []}
{"input": "A new bioencapsulation technology for microbial inoculants.", "output": {"entities": {}}, "schema": []}
{"input": "We linked hypersensitivity site 2 (HS2) from the locus control region (LCR) to a A gamma-globin gene (A gamma *) mutationally marked to allow its transcript to be distinguished from endogenous gamma-globin mRNA.", "output": {"entities": {"gene": [{"text": "A gamma-globin", "start": 81, "end": 95}, {"text": "A gamma *", "start": 102, "end": 111}, {"text": "gamma-globin", "start": 193, "end": 205}]}}, "schema": []}
{"input": "INTERVENTIONS--Patients allocated to treatment with levodopa/dopa decarboxylase inhibitor alone (arm 1), levodopa/decarboxylase inhibitor/selegiline in combination (arm 2), or bromocriptine (arm 3).", "output": {"entities": {"gene": [{"text": "levodopa/dopa decarboxylase", "start": 52, "end": 79}, {"text": "levodopa/decarboxylase", "start": 105, "end": 127}]}}, "schema": []}
{"input": "It contains three putative binding sites for transcription factor Sp1 as well as several short sequences that are similar to known cis-acting enhancers or binding sites for transcription factors.", "output": {"entities": {"gene": [{"text": "transcription factor Sp1", "start": 45, "end": 69}]}}, "schema": []}
{"input": "French bean contains a small family of genes encoding PAL and two of these genes, PAL2 and PAL3, have been shown to be differentially expressed at the mRNA level in bean tissues.", "output": {"entities": {"gene": [{"text": "genes encoding PAL", "start": 39, "end": 57}, {"text": "PAL2", "start": 82, "end": 86}, {"text": "PAL3", "start": 91, "end": 95}]}}, "schema": []}
{"input": "Plasma thromboxane B2 levels in the older group were about double those in younger piglets.", "output": {"entities": {}}, "schema": []}
{"input": "By stepwise linear multiple regression analysis, ionized magnesium was significantly related to cyclosporin trough level and total cholesterol but not to serum creatinine, time after transplant or the dose of cyclosporin.", "output": {"entities": {}}, "schema": []}
{"input": "The human insulin-like growth factor II (IGF-II) gene contains four promoters (P1, P2, P3 and P4).", "output": {"entities": {"gene": [{"text": "human insulin-like growth factor II", "start": 4, "end": 39}, {"text": "IGF-II", "start": 41, "end": 47}]}}, "schema": []}
{"input": "Moreover, in transient transfection assays, PU. 1 alone activated reporter constructs containing the JB cis-element, and the activation was shown to be dependent on a glutamine-rich sequence in the amino-terminal portion of PU. 1.", "output": {"entities": {"gene": [{"text": "PU. 1", "start": 44, "end": 49}, {"text": "PU. 1", "start": 224, "end": 229}]}}, "schema": []}
{"input": "Army veterans given yellow fever vaccine contaminated with hepatitis B virus in 1942 and controls and (b) a case-control study comparing veterans with hepatocellular carcinoma in Veterans Affairs hospitals with matched controls with respect to receipt of contaminated vaccine in 1942.", "output": {"entities": {}}, "schema": []}
{"input": "They were found to be seropositive for antibodies to hepatitis C virus by second-generation testing (RIBA 2, Ortho Diagnostic Systems Inc, Westwood, MA).", "output": {"entities": {}}, "schema": []}
{"input": "When introduced into recJ + strains, srjA mutations conferred hyperrecombinational and hyper-UVr phenotypes.", "output": {"entities": {"gene": [{"text": "recJ +", "start": 21, "end": 27}, {"text": "srjA", "start": 37, "end": 41}, {"text": "hyper-UVr", "start": 87, "end": 96}]}}, "schema": []}
{"input": "Distinguishing roles of the membrane-cytoskeleton and cadherin mediated cell-cell adhesion in generating different Na +, K (+)-ATPase distributions in polarized epithelia.", "output": {"entities": {"gene": [{"text": "cadherin", "start": 54, "end": 62}, {"text": "Na +, K (+)-ATPase", "start": 115, "end": 133}]}}, "schema": []}
{"input": "Neonatal lupus erythematosus is most often associated with autoantibodies against Ro and La antigens.", "output": {"entities": {"gene": [{"text": "Ro", "start": 82, "end": 84}, {"text": "La", "start": 89, "end": 91}]}}, "schema": []}
{"input": "Genetic abnormalities that could lead to mutagenesis include chromosomal abnormalities and single-gene mutations.", "output": {"entities": {}}, "schema": []}
{"input": "Hops, and L.", "output": {"entities": {}}, "schema": []}
{"input": "Continued absorption of amino acids by the NBB carrier (for neutral amino acids), the Y + system (for dibasic amino acids), and the PHE carrier were operative even during the actively purging stage of watery diarrhoea due to cholera.", "output": {"entities": {}}, "schema": []}
{"input": "1) CFDN, AMPC and MNZ showed a potent antimicrobial activity against H. pylori, and especially, AMPC showed a marked bactericidal activity in a short time.", "output": {"entities": {}}, "schema": []}
{"input": "Creutzfeldt-Jakob disease and lyophilised dura mater grafts: report of two cases.", "output": {"entities": {}}, "schema": []}
{"input": "A high mean intensity of CLTPA (standardized multivariate regression coefficient beta-0. 059, p = 0. 020) and a high maximal oxygen uptake (beta-0. 163, p < 0. 001) were associated with reduced plasma fibrinogen when adjusting for the strongest covariates.", "output": {"entities": {"gene": [{"text": "plasma fibrinogen", "start": 194, "end": 211}]}}, "schema": []}
{"input": "What young people think and do when the option for cystic fibrosis carrier testing is available.", "output": {"entities": {}}, "schema": []}
{"input": "A patient matches a PIC patient if both have the same mechanism of injury, the same coding of Revised Trauma Score variables (Glascow Coma Scale score, systolic blood pressure, respiratory rate), the same coded age per A Severity Characterization of Trauma) (ASCOT), and if they differ by no more than 0. 5 for A, B, and C (the ASCOT components for serious injuries).", "output": {"entities": {}}, "schema": []}
{"input": "Skin and bowel TPO2 varied with DO2 and each other (P < 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "We have isolated a cosmid containing DNA that corresponds to the site of transposon insertion in 257DH4 and have localized Tn5 on an 8. 0 kb EcoRI fragment.", "output": {"entities": {"gene": [{"text": "Tn5", "start": 123, "end": 126}, {"text": "8. 0 kb EcoRI fragment", "start": 133, "end": 155}]}}, "schema": []}
{"input": "The scr regulon of pUR400 and the chromosomally encoded scr regulon of Klebsiella pneumoniae KAY2026 are both negatively controlled by a specific repressor (ScrR).", "output": {"entities": {"gene": [{"text": "scr regulon", "start": 4, "end": 15}, {"text": "chromosomally encoded scr regulon of Klebsiella pneumoniae KAY2026", "start": 34, "end": 100}, {"text": "ScrR", "start": 157, "end": 161}]}}, "schema": []}
{"input": "Although the molecular mechanisms involved in this regulation are currently being elucidated, very little is known about the trans-acting factors that allow expression of the nitrate and nitrite reductase genes which code for the first enzymes in the pathway.", "output": {"entities": {"gene": [{"text": "nitrate and nitrite reductase genes", "start": 175, "end": 210}]}}, "schema": []}
{"input": "The Ntl1 gene is present as a unique copy in the diploid N. plumbaginifolia species.", "output": {"entities": {"gene": [{"text": "Ntl1 gene", "start": 4, "end": 13}]}}, "schema": []}
{"input": "Transient transfection experiments revealed that Pax-8 isoforms a and b, but not c and d, strongly stimulate transcription from a promoter containing six copies of a paired-domain recognition sequence.", "output": {"entities": {"gene": [{"text": "Pax-8 isoforms a and b", "start": 49, "end": 71}, {"text": "paired-domain recognition sequence", "start": 166, "end": 200}]}}, "schema": []}
{"input": "The amino-terminal third of the protein contains a high-mobility-group motif characteristic of DNA-binding proteins.", "output": {"entities": {"gene": [{"text": "high-mobility-group motif", "start": 51, "end": 76}]}}, "schema": []}
{"input": "We have examined the ability of various NF-kappa B subunits to bind to, and activate transcription from, the IL-8 promoter.", "output": {"entities": {"gene": [{"text": "NF-kappa B subunits", "start": 40, "end": 59}, {"text": "IL-8 promoter", "start": 109, "end": 122}]}}, "schema": []}
{"input": "When multiple copies of the IL-1 beta NF-kappa B site were linked to an enhancerless simian virus 40 promoter, this element was able to mediate phorbol ester-or lipopolysaccharide-inducible gene expression.", "output": {"entities": {"gene": [{"text": "IL-1 beta NF-kappa B site", "start": 28, "end": 53}, {"text": "simian virus 40 promoter", "start": 85, "end": 109}]}}, "schema": []}
{"input": "We found that the 3'-end-adjacent sequence CA (N) 3-10AGTNNAA, conserved in plant Pol II-specific U snRNA genes, is essential for the 3'-end formation of U2 transcripts and, similar to the vertebrate 3' box, is highly tolerant to mutation.", "output": {"entities": {"gene": [{"text": "Pol II", "start": 82, "end": 88}, {"text": "U snRNA genes", "start": 98, "end": 111}, {"text": "U2 transcripts", "start": 154, "end": 168}]}}, "schema": []}
{"input": "These results indicate that Rb protein is interacting with some component (s) of the cell cycle-regulatory machinery during G2 phase.", "output": {"entities": {"gene": [{"text": "Rb protein", "start": 28, "end": 38}]}}, "schema": []}
{"input": "MDBP from HeLa and Raji cells formed DNA-protein complexes with X-box oligonucleotides that coelectrophoresed with those containing standard MDBP sites.", "output": {"entities": {"gene": [{"text": "MDBP", "start": 0, "end": 4}, {"text": "MDBP sites", "start": 141, "end": 151}]}}, "schema": []}
{"input": "Transgenic mice harboring the rat TnI-CAT fusion gene expressed the reporter specifically in the skeletal muscle.", "output": {"entities": {"gene": [{"text": "TnI", "start": 34, "end": 37}, {"text": "CAT", "start": 38, "end": 41}]}}, "schema": []}
{"input": "The ADP-ribosylation factor (ARF) family is one of four subfamilies of the RAS superfamily of low molecular weight GTP-binding proteins (G proteins).", "output": {"entities": {"gene": [{"text": "ADP-ribosylation factor", "start": 4, "end": 27}, {"text": "ARF", "start": 29, "end": 32}, {"text": "RAS superfamily", "start": 75, "end": 90}, {"text": "low molecular weight GTP-binding proteins", "start": 94, "end": 135}, {"text": "G proteins", "start": 137, "end": 147}]}}, "schema": []}
{"input": "The E1 gene is located within the first intron of the gene for RCC1, a protein that regulates onset of mitosis.", "output": {"entities": {"gene": [{"text": "E1 gene", "start": 4, "end": 11}, {"text": "RCC1", "start": 63, "end": 67}]}}, "schema": []}
{"input": "Genomic Southern blot analysis and chromosome mapping showed that GPRK6 hybridizes to two closely related genes located on chromosomes 5 and 13 and are, therefore, distinct from the GPRK located near the Huntington disease locus on chromosome 4.", "output": {"entities": {"gene": [{"text": "GPRK6", "start": 66, "end": 71}, {"text": "GPRK", "start": 182, "end": 186}, {"text": "Huntington disease locus", "start": 204, "end": 228}]}}, "schema": []}
{"input": "Metabolic labeling studies in S. cerevisiae and co-expression of nmt72p with several protein substrates of Nmt1p in Escherichia coli indicate that the Leu99--> Pro substitution causes a reduction in the acylation of some but not all protein substrates.", "output": {"entities": {"gene": [{"text": "nmt72p", "start": 65, "end": 71}, {"text": "Nmt1p", "start": 107, "end": 112}]}}, "schema": []}
{"input": "These CTD kinases, designated CTDK1 and CTDK2, are fractionated by chromatography on Mono Q.", "output": {"entities": {"gene": [{"text": "CTD kinases", "start": 6, "end": 17}, {"text": "CTDK1", "start": 30, "end": 35}, {"text": "CTDK2", "start": 40, "end": 45}]}}, "schema": []}
{"input": "Previously, we identified a 51-bp promoter fragment, oligo31/32, which conferred heat shock inducibility on the heterologous CYC1-lacZ reporter gene in S. cerevisiae (N.", "output": {"entities": {"gene": [{"text": "CYC1", "start": 125, "end": 129}, {"text": "lacZ", "start": 130, "end": 134}]}}, "schema": []}
{"input": "To identify factors that may modify the heterosexual transmission of human T cell leukemia/lymphoma virus type I (HTLV-I), 534 married couples enrolled in the Miyazaki Cohort Study between November 1984 and April 1989 were studied: 95 husband HTLV-I-seropositive (H +)/wife seropositive (W +), 33 H +/W-, 64 H-/W +, and 342 H-/W-.", "output": {"entities": {}}, "schema": []}
{"input": "To characterize the expression of this DNA repair enzyme, we have isolated the corresponding genomic clone.", "output": {"entities": {"gene": [{"text": "DNA repair enzyme", "start": 39, "end": 56}]}}, "schema": []}
{"input": "L., Stange, G., Markovich, D., Biber, J., Testar, X., Zorzano, A., Palacin, M., and Murer, H.", "output": {"entities": {}}, "schema": []}
{"input": "The nucleotide sequence of the gene predicts a polypeptide of 215 amino acids (25. 2 kDa) with two putative membrane-spanning domains.", "output": {"entities": {}}, "schema": []}
{"input": "SAECG, echocardiography and thallium-201 imaging were performed before and 1 month after attempted angioplasty.", "output": {"entities": {}}, "schema": []}
{"input": "They were called PACE4 and PC4.", "output": {"entities": {"gene": [{"text": "PACE4", "start": 17, "end": 22}, {"text": "PC4", "start": 27, "end": 30}]}}, "schema": []}
{"input": "Both fusion proteins form stable specific complexes with a short DNA duplex harboring the CTGT (at) 4ACAG consensus sequence of the LexA repressor.", "output": {"entities": {"gene": [{"text": "LexA repressor", "start": 132, "end": 146}]}}, "schema": []}
{"input": "Ten selenocysteine residues (deduced) are present.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS: Free protein S deficiency is common among hospitalized patients, even in the absence of a recognized predisposing condition.", "output": {"entities": {"gene": [{"text": "protein S", "start": 18, "end": 27}]}}, "schema": []}
{"input": "During the past decade, different types of endogenous retroviral sequences have been defined in the human genome usually by low stringency hybridization employing DNA probes of evolutionary conserved animal retrovirus genes.", "output": {"entities": {}}, "schema": []}
{"input": "As the components of these complexes, at least five TRBPs (p30, p37, p46, p50, and p56) showing specific binding to the TAR RNA were detected in the uv cross-linking assay.", "output": {"entities": {"gene": [{"text": "TRBPs", "start": 52, "end": 57}, {"text": "p30", "start": 59, "end": 62}, {"text": "p37", "start": 64, "end": 67}, {"text": "p46", "start": 69, "end": 72}, {"text": "p50", "start": 74, "end": 77}, {"text": "p56", "start": 83, "end": 86}]}}, "schema": []}
{"input": "The obvious functional necessity for editing in kinetoplastid mitochondria is the formation of translatable mRNAs.", "output": {"entities": {}}, "schema": []}
{"input": "An extensive inverted repeat is present 3' of rpeA; inverted repeats are found downstream of all PE operons sequenced to date, although the sequence is not conserved.", "output": {"entities": {"gene": [{"text": "rpeA", "start": 46, "end": 50}, {"text": "PE operons", "start": 97, "end": 107}]}}, "schema": []}
{"input": "Large differences between the groups were not observed in HA-synthesizing enzyme activity, but degradative enzyme activity was much higher in aspirin-induced asthma-related polyps than in other types of nasal polyps tested.", "output": {"entities": {"gene": [{"text": "HA-synthesizing enzyme", "start": 58, "end": 80}]}}, "schema": []}
{"input": "In the multivariate analysis, six variables were independently correlated with survival: blood urea nitrogen level, serum aspartate aminotransferase level, community-acquired vs. hospital-acquired peritonitis, age, Child-Pugh score and ileus.", "output": {"entities": {"gene": [{"text": "serum aspartate aminotransferase", "start": 116, "end": 148}]}}, "schema": []}
{"input": "Localization of the intronless gene coding for calmodulin-like protein CLP to human chromosome 10p13-ter.", "output": {"entities": {"gene": [{"text": "calmodulin-like protein CLP", "start": 47, "end": 74}]}}, "schema": []}
{"input": "In wandering stage larvae, the OBP transcript appeared to be at least 250-fold less abundant than ribosomal RNA.", "output": {"entities": {"gene": [{"text": "OBP transcript", "start": 31, "end": 45}]}}, "schema": []}
{"input": "One such mutant also affects the overlapping-10 hexamer of PR and results in reduced occupancy by both MerR and RNA polymerase, likely as a result of inefficient transcriptional initiation of merR mRNA.", "output": {"entities": {"gene": [{"text": "MerR", "start": 103, "end": 107}, {"text": "RNA polymerase", "start": 112, "end": 126}, {"text": "merR mRNA", "start": 192, "end": 201}]}}, "schema": []}
{"input": "This promoter could direct the constitutive expression of the reporter beta-galactosidase at high frequency in transfected colonies of transformed cells that express L-plastin constitutively; by contrast, this promoter was virtually inactive in transfected colonies of normal fibroblasts and it exhibited a low frequency of constitutive activation in transfected colonies of in vitro SV40-transformed fibroblasts which did not exhibit L-plastin expression.", "output": {"entities": {"gene": [{"text": "beta-galactosidase", "start": 71, "end": 89}, {"text": "L-plastin", "start": 166, "end": 175}, {"text": "L-plastin", "start": 435, "end": 444}]}}, "schema": []}
{"input": "The half-life of the serum-induced CBP/tk binding activity was estimated to be less than 1 h. (ABSTRACT TRUNCATED AT 400 WORDS)", "output": {"entities": {"gene": [{"text": "CBP", "start": 35, "end": 38}, {"text": "tk", "start": 39, "end": 41}]}}, "schema": []}
{"input": "The gene includes three exons and two introns within 1. 6 kilobases of DNA, and the entire open reading frame for glycoprotein IX is included within the third exon.", "output": {"entities": {"gene": [{"text": "glycoprotein IX", "start": 114, "end": 129}]}}, "schema": []}
{"input": "Rhizobium meliloti large plasmid pRmeGR4b carries the nodulation competitiveness locus nfe responsible for the nodulation efficiency and competitive ability of strain GR4 on alfalfa roots.", "output": {"entities": {"gene": [{"text": "nfe", "start": 87, "end": 90}]}}, "schema": []}
{"input": "Further, the ability of recombinant beta and/or gamma chains to function in defined biochemical assays of beta gamma activity was assessed for membrane extracts and supernatant fractions from infected Sf9 cells.", "output": {"entities": {}}, "schema": []}
{"input": "This report describes the identification of a gene of related function, SMD1, located immediately 3' to PRP38.", "output": {"entities": {"gene": [{"text": "SMD1", "start": 72, "end": 76}, {"text": "PRP38", "start": 104, "end": 109}]}}, "schema": []}
{"input": "These data establish Smd1p as a required component of the cellular splicing apparatus and a factor in snRNA maturation and stability.", "output": {"entities": {"gene": [{"text": "Smd1p", "start": 21, "end": 26}]}}, "schema": []}
{"input": "This study compared the gross and fine motor performance of 14 traumatically brain-injured children (five to 15 years old, with loss of consciousness for at least 24 hours) to 14 normal children group matched for age and sex.", "output": {"entities": {}}, "schema": []}
{"input": "We compared the parameters pleural adenosine deaminase (PADA, determined in 405 patients), the PADA/serum ADA ratio (P/SADA; 276 cases), pleural lysozyme (PLYS, 276 cases), the PLYS/serum LYS ratio (P/SLYS; 276 cases), and pleural interferon gamma (IFN, 145 cases) regarding their ability to differentiate tuberculous pleural effusions from others.", "output": {"entities": {"gene": [{"text": "pleural adenosine deaminase", "start": 27, "end": 54}, {"text": "PADA", "start": 56, "end": 60}, {"text": "PADA", "start": 95, "end": 99}, {"text": "serum ADA", "start": 100, "end": 109}, {"text": "P", "start": 117, "end": 118}, {"text": "SADA", "start": 119, "end": 123}, {"text": "pleural lysozyme", "start": 137, "end": 153}, {"text": "PLYS", "start": 155, "end": 159}, {"text": "PLYS", "start": 177, "end": 181}, {"text": "serum LYS", "start": 182, "end": 191}, {"text": "P", "start": 199, "end": 200}, {"text": "SLYS", "start": 201, "end": 205}, {"text": "pleural interferon gamma", "start": 223, "end": 247}, {"text": "IFN", "start": 249, "end": 252}]}}, "schema": []}
{"input": "These exons were identified by cloning and sequencing cDNAs obtained by polymerase chain reaction amplification of a fibroblast cDNA library.", "output": {"entities": {}}, "schema": []}
{"input": "Deletion of the apeA gene, either with or without deletion of other proteinases (protease IV and aminopeptidase N), did not have any effect on cell growth in the various media tested.", "output": {"entities": {"gene": [{"text": "apeA gene", "start": 16, "end": 25}, {"text": "protease IV", "start": 81, "end": 92}, {"text": "aminopeptidase N", "start": 97, "end": 113}]}}, "schema": []}
{"input": "In Experiment 2 scopolamine hydrobromide, 0. 5 and 1. 0 mg/kg i. p., was administered 1 h before each electrical stimulation until each rat showed the stage-3 seizure.", "output": {"entities": {}}, "schema": []}
{"input": "PNT, ADD and BSS in the initial stage of kindling, kindling rate for the stage-3 and-5 seizures, seizure parameters at the first stage-3 and-5 were recorded and compared to the values of saline-treated, control group.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS.", "output": {"entities": {}}, "schema": []}
{"input": "There was a positive correlation between pyridinium cross-link excretion and thyroid hormone concentrations.", "output": {"entities": {}}, "schema": []}
{"input": "Mutations truncating as many as 143 C-terminal residues from the transcriptional activator encoded by the areA gene, mediating nitrogen metabolite repression in Aspergillus nidulans, do not significantly reduce the ability of the areA product to activate expression of most genes under areA control.", "output": {"entities": {"gene": [{"text": "areA gene", "start": 106, "end": 115}, {"text": "areA product", "start": 230, "end": 242}, {"text": "areA", "start": 286, "end": 290}]}}, "schema": []}
{"input": "A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis.", "output": {"entities": {"gene": [{"text": "adenovirus 2/5 E1a protein", "start": 30, "end": 56}, {"text": "ras", "start": 165, "end": 168}]}}, "schema": []}
{"input": "These studies demonstrate that both G alpha i genes are dynamically regulated in LLC-PK1 cells by both growth, differentiation, and hormone signals.", "output": {"entities": {"gene": [{"text": "G alpha i genes", "start": 36, "end": 51}]}}, "schema": []}
{"input": "Constructs containing the full-length PfCPK cDNA have been expressed in Escherichia coli at a high level to generate a 60-kDa recombinant protein.", "output": {"entities": {"gene": [{"text": "full-length PfCPK cDNA", "start": 26, "end": 48}]}}, "schema": []}
{"input": "In mitogen-stimulated splenocytes, Gfi-1 expression begins to rise at 12 h after stimulation and reaches very high levels after 50 h, suggesting that it may be functionally involved in events occurring after the interaction of IL-2 with its receptor, perhaps during the transition from the G1 to the S phase of the cell cycle.", "output": {"entities": {"gene": [{"text": "Gfi-1", "start": 35, "end": 40}, {"text": "IL-2", "start": 227, "end": 231}]}}, "schema": []}
{"input": "We have isolated and characterized the GCD6 and GCD7 genes and shown that their products are required to repress GCN4 translation under nonstarvation conditions.", "output": {"entities": {"gene": [{"text": "GCD6", "start": 39, "end": 43}, {"text": "GCD7 genes", "start": 48, "end": 58}, {"text": "GCN4", "start": 113, "end": 117}]}}, "schema": []}
{"input": "The plateau MO2 value was that predicted by allometric relation.", "output": {"entities": {}}, "schema": []}
{"input": "While the latter corresponded to a protein of 824 amino acids, an upstream open reading frame (uORF) within the 5' leader could potentially encode a 54 amino acid peptide.", "output": {"entities": {}}, "schema": []}
{"input": "The SCH9 protein kinase mRNA contains a long 5' leader with a small open reading frame.", "output": {"entities": {"gene": [{"text": "SCH9 protein kinase mRNA", "start": 4, "end": 28}]}}, "schema": []}
{"input": "In contrast to T cells, in fibroblasts PILOT gene expression requires only one signal (PMA) and is not affected by CyA.", "output": {"entities": {"gene": [{"text": "PILOT gene", "start": 39, "end": 49}]}}, "schema": []}
{"input": "Histochemical localization of GUS revealed promoter function in leaf epidermis, mesophyll and vascular bundles, in the cortex and vascular cylinder of the root.", "output": {"entities": {"gene": [{"text": "GUS", "start": 30, "end": 33}]}}, "schema": []}
{"input": "In order to investigate how these expression patterns are established, we fused promoter regions of an acidic and a basic glucanase gene to the beta-glucuronidase (GUS) reporter gene and examined expression of these constructs in transgenic tobacco plants.", "output": {"entities": {"gene": [{"text": "glucanase gene", "start": 122, "end": 136}, {"text": "beta-glucuronidase", "start": 144, "end": 162}, {"text": "GUS", "start": 164, "end": 167}]}}, "schema": []}
{"input": "Sudomoina, A.", "output": {"entities": {}}, "schema": []}
{"input": "Zinc fingers (Zf) are a common structural motif found in many nucleic acid-binding proteins.", "output": {"entities": {}}, "schema": []}
{"input": "The deduced bovine EFIA #1 amino acid (aa) sequence is 98% identical to rat EFIA and 100% identical to human EFIA/DbpB/YB-1 family member DNA-binding protein B (DbpB).", "output": {"entities": {"gene": [{"text": "EFIA #1", "start": 19, "end": 26}, {"text": "EFIA", "start": 76, "end": 80}, {"text": "EFIA", "start": 109, "end": 113}, {"text": "DbpB", "start": 114, "end": 118}, {"text": "YB-1", "start": 119, "end": 123}, {"text": "DNA-binding protein B", "start": 138, "end": 159}, {"text": "DbpB", "start": 161, "end": 165}]}}, "schema": []}
{"input": "Effect of tracheal insufflation of deferoxamine on acute ozone toxicity in rats.", "output": {"entities": {}}, "schema": []}
{"input": "Localization of the insertion locus in the yeast genome and complementation studies with the temperature-sensitive mutant indicate that the two mutations are allelic.", "output": {"entities": {}}, "schema": []}
{"input": "Replacement of the spacer sequence between the two ARMs with a shorter stretch of sequence also reduced RNA binding in vitro.", "output": {"entities": {}}, "schema": []}
{"input": "Second, the transcription factor Gal-ER was rendered more potent and less susceptible to cell type-specific variation by fusing the strong activating domain of the herpesvirus protein VP16 onto its C terminus.", "output": {"entities": {"gene": [{"text": "transcription factor Gal-ER", "start": 12, "end": 39}, {"text": "herpesvirus protein VP16", "start": 164, "end": 188}]}}, "schema": []}
{"input": "The exogenous fos gene was rapidly induced to maximal levels within 1-2 hr of estrogen addition.", "output": {"entities": {"gene": [{"text": "fos gene", "start": 14, "end": 22}]}}, "schema": []}
{"input": "Elimination of Haemophilus influenzae type b meningitis after introduction of vaccination", "output": {"entities": {}}, "schema": []}
{"input": "Endosonography accurately assessed tumor extension in two T2 tumors, 14 T3 tumors, and seven T4 tumors.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of cell cycle regulation in the budding yeast Saccharomyces cerevisiae has shown that a central regulatory protein kinase, Cdc28, undergoes changes in activity through the cell cycle by associating with distinct groups of cyclins that accumulate at different times.", "output": {"entities": {"gene": [{"text": "Cdc28", "start": 132, "end": 137}, {"text": "cyclins", "start": 231, "end": 238}]}}, "schema": []}
{"input": "Overlapping clones representing full-length cDNAs for MMI alpha were obtained from mouse brain.", "output": {"entities": {"gene": [{"text": "MMI alpha", "start": 54, "end": 63}]}}, "schema": []}
{"input": "The method involves preliminary isolation of oxiracetam and internal standard from plasma by solid-phase extraction prior to the formation of their n-propyl carbamate derivatives.", "output": {"entities": {}}, "schema": []}
{"input": "Pathways linking the olfactory bulbs with the medial preoptic anterior hypothalamus are important for intermale aggression in mice.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast, rats receiving U74500A (2 mg/kg i. v. infusion commencing 30 min prior to revascularisation) exhibited enhanced GMBF throughout reperfusion [PI 10 min: 3. 26 (2. 56-3. 63); 120 min: 2. 03 (1. 73-2. 25); 240 min: 2. 13 (1. 75-2. 44), p < 0. 01 vs. controls and normals] with complete muscle salvage [GMV 100% in all reperfused muscles, p < 0. 01 vs. controls, not significant (NS) vs. normals and 6 h ischaemia]. (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {}}, "schema": []}
{"input": "Sequencing of a 1. 3-kilobase fragment of the 5'-flanking region of the TSG6 gene identified TATA-like and CAAT sequences near the transcription start site.", "output": {"entities": {"gene": [{"text": "TSG6 gene", "start": 72, "end": 81}]}}, "schema": []}
{"input": "The region that imparts inducibility by IL-1 or TNF (positions-165 to-58) contains potential binding sites for IRF-1 and-2, AP-1, and NF-IL-6.", "output": {"entities": {"gene": [{"text": "IL-1", "start": 40, "end": 44}, {"text": "TNF", "start": 48, "end": 51}, {"text": "IRF-1 and-2", "start": 111, "end": 122}, {"text": "AP-1", "start": 124, "end": 128}, {"text": "NF-IL-6", "start": 134, "end": 141}]}}, "schema": []}
{"input": "Ig-alpha and Ig-beta contain extended cytoplasmic structure (61 and 48 amino acids, respectively) and associate with cytoplasmic effectors indicating that they are directly involved in signal transduction.", "output": {"entities": {"gene": [{"text": "Ig-alpha", "start": 0, "end": 8}, {"text": "Ig-beta", "start": 13, "end": 20}]}}, "schema": []}
{"input": "We studied the functional interaction between human embryonic zeta 2 globin promoter and the alpha globin regulatory element (HS-40) located 40 kb upstream of the zeta 2 globin gene.", "output": {"entities": {"gene": [{"text": "zeta 2 globin", "start": 62, "end": 75}, {"text": "alpha globin regulatory element", "start": 93, "end": 124}, {"text": "HS-40", "start": 126, "end": 131}, {"text": "zeta 2 globin gene", "start": 163, "end": 181}]}}, "schema": []}
{"input": "It was shown by transient expression assay that HS-40 behaved as an authentic enhancer for high-level zeta 2 globin promoter activity in K562 cells, an erythroid cell line of embryonic and/or fetal origin.", "output": {"entities": {"gene": [{"text": "HS-40", "start": 48, "end": 53}, {"text": "zeta 2 globin promoter", "start": 102, "end": 124}]}}, "schema": []}
{"input": "Initial results indicate that this 23S pre-rRNA is the same as the species detected on depletion of the small nucleolar RNA-associated proteins NOP1 and GAR1 and in an snr10 mutant strain.", "output": {"entities": {"gene": [{"text": "23S pre-rRNA", "start": 35, "end": 47}, {"text": "small nucleolar RNA-associated proteins NOP1", "start": 104, "end": 148}, {"text": "GAR1", "start": 153, "end": 157}, {"text": "snr10 mutant", "start": 168, "end": 180}]}}, "schema": []}
{"input": "Breitbart, L.", "output": {"entities": {}}, "schema": []}
{"input": "This study evaluates the feasibility of indirect mesenteric lymphangiography as a colonoscopic technique in a canine model.", "output": {"entities": {}}, "schema": []}
{"input": "Internal amino acid sequence has now been obtained from this protein which shares 50-100% sequence identity with sequences encoded by mammalian G alpha 11 and G alpha q cDNAs.", "output": {"entities": {"gene": [{"text": "mammalian G alpha 11", "start": 134, "end": 154}, {"text": "G alpha q cDNAs", "start": 159, "end": 174}]}}, "schema": []}
{"input": "Estradiol is known to induce expression of certain proto-oncogenes, and this led us to examine potential regulatory regions of the cellular c-fos oncogene.", "output": {"entities": {"gene": [{"text": "cellular c-fos oncogene", "start": 131, "end": 154}]}}, "schema": []}
{"input": "Air lead was not a significant explanatory variable.", "output": {"entities": {}}, "schema": []}
{"input": "We now show that regulation of flaN transcription in vivo depends on a sigma 54 promoter and two ftr elements located downstream of the transcription start site at + 86 (ftr2) and + 120 (ftr3).", "output": {"entities": {"gene": [{"text": "flaN", "start": 31, "end": 35}, {"text": "sigma 54 promoter", "start": 71, "end": 88}]}}, "schema": []}
{"input": "Fibular dimelia with deficiency of the tibia.", "output": {"entities": {}}, "schema": []}
{"input": "This prospective study compared the measured energy expenditures of 30 patients using indirect calorimetry with their predicted basal energy expenditure according to the Harris-Benedict equation, or their calculated energy expenditure derived from basal energy expenditure times, an activity factor, and a stress factor.", "output": {"entities": {}}, "schema": []}
{"input": "However, after repeated infections, hypobiotic larvae were numerous.", "output": {"entities": {}}, "schema": []}
{"input": "This was performed in a double blinded, randomized, placebo-controlled study.", "output": {"entities": {}}, "schema": []}
{"input": "Group I consisted of six noncholestatic patients; group II consisted of nine mildly cholestatic patients with mild hepatic impairment (conjugated bilirubin, 47 mumol liter-1; alkaline phosphatase, 280 IU liter-1; gamma-glutamyltranspeptidase, 190 IU liter-1); group III consisted of six benign intrahepatic cholestatic patients with high isolated conjugated hyperbilirubinemia (98. 1 mumol liter-1).", "output": {"entities": {"gene": [{"text": "alkaline phosphatase", "start": 175, "end": 195}, {"text": "gamma-glutamyltranspeptidase", "start": 213, "end": 241}]}}, "schema": []}
{"input": "There was either no change or an improvement in renographic findings (t1/2 time and/or split function) in 40 patients (93%).", "output": {"entities": {}}, "schema": []}
{"input": "We discuss the need to use animals older than 3 months for the study of' adult' regeneration phenomena since 3-month-old rats may be somewhat immature.", "output": {"entities": {}}, "schema": []}
{"input": "Nuclear beta II PKC, like p34cdc2 kinase, may function to regulate nuclear lamina structural stability during cell cycle.", "output": {"entities": {"gene": [{"text": "Nuclear beta II PKC", "start": 0, "end": 19}, {"text": "p34cdc2 kinase", "start": 26, "end": 40}]}}, "schema": []}
{"input": "In situ copper-phenanthroline footprinting of individual gel shift assembly intermediates shows that on the 302-nucleotide G4oric, the first two SSB tetramers assemble at random, but the addition of more SSB tetramers results in formation of a unique structure.", "output": {"entities": {"gene": [{"text": "SSB tetramers", "start": 145, "end": 158}, {"text": "SSB tetramers", "start": 204, "end": 217}]}}, "schema": []}
{"input": "Effects of intramammary endotoxin infusion on milking-induced oxytocin release.", "output": {"entities": {"gene": [{"text": "oxytocin", "start": 62, "end": 70}]}}, "schema": []}
{"input": "A rat cDNA that encodes eIF-5 has been isolated and expressed in Escherichia coli to yield a catalytically active eIF-5 protein.", "output": {"entities": {"gene": [{"text": "eIF-5", "start": 24, "end": 29}, {"text": "eIF-5 protein", "start": 114, "end": 127}]}}, "schema": []}
{"input": "In F42A-stimulated internalization assays on forskolin-induced YT-1 cells, the IL-2R alpha chain is consistently endocytosed together with the IL-2R beta subunit indicating that IL-2R alpha is stably associated with the F42A-IL-2R beta complex even though the alpha-subunit contributes little if any affinity to the F42A binding reaction.", "output": {"entities": {"gene": [{"text": "IL-2R alpha chain", "start": 79, "end": 96}, {"text": "IL-2R beta subunit", "start": 143, "end": 161}, {"text": "IL-2R alpha", "start": 178, "end": 189}, {"text": "F42A-IL-2R beta complex", "start": 220, "end": 243}]}}, "schema": []}
{"input": "The microcirculatory dynamics of prostaglandin E1 and/or nicardipine and their different reactions in the hyper-and hypodynamic state of septic shock in a rat model", "output": {"entities": {}}, "schema": []}
{"input": "The short-term synthesis and infant-regulated removal of milk in lactating women.", "output": {"entities": {}}, "schema": []}
{"input": "Based on these results, a new model for the regulation of nif/fix gene expression in A. caulinodans is proposed.", "output": {"entities": {"gene": [{"text": "nif", "start": 58, "end": 61}, {"text": "fix", "start": 62, "end": 65}]}}, "schema": []}
{"input": "Nitric oxide inhalation selectively reduces pulmonary hypertension in porcine endotoxin shock and improves arterial oxygenation and pH with a marked attenuation of sympathetic activation.", "output": {"entities": {}}, "schema": []}
{"input": "B cell-specific mb-1 and B29 genes encode the alpha/beta components of the BCR-associated complex in mature sIgM + B cells.", "output": {"entities": {"gene": [{"text": "mb-1", "start": 16, "end": 20}, {"text": "B29 genes", "start": 25, "end": 34}, {"text": "BCR-associated complex", "start": 75, "end": 97}, {"text": "sIgM +", "start": 108, "end": 114}]}}, "schema": []}
{"input": "Bipolarity in Jungian type theory and the Myers-Briggs Type Indicator.", "output": {"entities": {}}, "schema": []}
{"input": "A variety of nuclear ribonucleoproteins are believed to associate directly with nascent RNA polymerase II transcripts and remain associated during subsequent nuclear RNA processing reactions, including pre-mRNA polyadenylation and splicing as well as nucleocytoplasmic mRNA transport.", "output": {"entities": {"gene": [{"text": "RNA polymerase II transcripts", "start": 88, "end": 117}]}}, "schema": []}
{"input": "Mutations at three sites have larger effects in muscle than nonmuscle cells; an A/T-rich site mutation has a pronounced effect in both striated muscle types, mutations at the MEF1 (Right E-box) site are relatively specific to expression in skeletal muscle, and mutations at the CArG site are relatively specific to expression in cardiac muscle.", "output": {"entities": {"gene": [{"text": "MEF1 (Right E-box) site", "start": 175, "end": 198}]}}, "schema": []}
{"input": "Transient transfection analysis with these mutations revealed that only a 10-bp region, containing precisely the Ets and proximal LyF-1 binding sites, was needed for D' activity.", "output": {"entities": {"gene": [{"text": "Ets", "start": 113, "end": 116}, {"text": "LyF-1 binding sites", "start": 130, "end": 149}]}}, "schema": []}
{"input": "However, despite its relationship to the TR, Rev-Erb bound poorly to TR binding sites.", "output": {"entities": {"gene": [{"text": "TR", "start": 41, "end": 43}, {"text": "Rev", "start": 45, "end": 48}, {"text": "Erb", "start": 49, "end": 52}, {"text": "TR binding sites", "start": 69, "end": 85}]}}, "schema": []}
{"input": "We report here that a 25-bp promoter element previously shown to be important for the G1-S activation of the human thymidine kinase (htk) promoter in growth-stimulated cells is a cellular target of cyclin A and the p33cdk2 complexes.", "output": {"entities": {"gene": [{"text": "human thymidine kinase", "start": 109, "end": 131}, {"text": "htk", "start": 133, "end": 136}, {"text": "cyclin A", "start": 198, "end": 206}, {"text": "p33cdk2 complexes", "start": 215, "end": 232}]}}, "schema": []}
{"input": "These protective influences were observed throughout the range of filling pressures measured, from 0 to 30 mmHg.", "output": {"entities": {}}, "schema": []}
{"input": "DNase I footprinting with rat liver nuclear extracts identified 7 major protein-binding domains termed P1 through P7 in a 796 base pair DNA fragment (base pairs-763 to + 33).", "output": {"entities": {"gene": [{"text": "DNase I", "start": 0, "end": 7}]}}, "schema": []}
{"input": "Neither clone encoded the cognate endonuclease.", "output": {"entities": {}}, "schema": []}
{"input": "The nifJ and nifH promoters of Klebsiella pneumoniae are divergently transcribed sigma 54-dependent promoters that are positively activated by the NifA protein.", "output": {"entities": {"gene": [{"text": "nifJ", "start": 4, "end": 8}, {"text": "nifH promoters of Klebsiella pneumoniae", "start": 13, "end": 52}, {"text": "sigma 54-dependent promoters", "start": 81, "end": 109}, {"text": "NifA protein", "start": 147, "end": 159}]}}, "schema": []}
{"input": "Both inhaled and superfused isoflurane dilated the baseline vein diameter before stimulation.", "output": {"entities": {}}, "schema": []}
{"input": "Prevalence of rheumatoid arthritis and rheumatoid factor in women: evidence for a secular decline.", "output": {"entities": {"gene": [{"text": "rheumatoid factor", "start": 39, "end": 56}]}}, "schema": []}
{"input": "Although olfactory associative conditioning in newborn rats produces marked structural and functional changes in the olfactory bulb, recent evidence suggests that extrabulbar circuits must be involved in storing these early memories.", "output": {"entities": {}}, "schema": []}
{"input": "The fission yeast dsk1 + gene, a multicopy suppressor for cold-sensitive dis1 mutants, encodes a novel 61-kd protein kinase.", "output": {"entities": {"gene": [{"text": "fission yeast dsk1 + gene", "start": 4, "end": 29}, {"text": "dis1 mutants", "start": 73, "end": 85}]}}, "schema": []}
{"input": "Closure of the patent ductus arteriosus with a Ligaclip through a minithoracotomy.", "output": {"entities": {}}, "schema": []}
{"input": "Sequence comparison between the translated ORF and a protein database reveal between 26. 5 and 23. 4% aa sequence homology to bacterial transmembrane (TM) proteins including those mediating chloramphenicol (Cm) and tetracycline (Tc) resistance and an arabinose-proton symport protein.", "output": {"entities": {"gene": [{"text": "bacterial transmembrane (TM) proteins", "start": 126, "end": 163}]}}, "schema": []}
{"input": "The strategies by which hepatitis B and hepatitis D can be diminished and eventually eliminated are: immunization, measures to prevent exposure to infective blood or blood derivatives and education (in particular awareness that hepatitis B is a sexually transmitted disease).", "output": {"entities": {}}, "schema": []}
{"input": "The technical construction of the mouth protectors is illustrated, as is the need for instrumentation and its costs and the materials required to manufacture these mouth protectors.", "output": {"entities": {}}, "schema": []}
{"input": "Three patients had well-, 6 patients had moderately-, and 5 patients had poorly-differentiated adenocarcinoma of the prostate.", "output": {"entities": {}}, "schema": []}
{"input": "Spontaneous burst firing in cat primary auditory cortex: age and depth dependence and its effect on neural interaction measures.", "output": {"entities": {}}, "schema": []}
{"input": "By applying the potentiometric method, in aqueous medium of ionic strength mu = 0. 2, the stability constants, log beta 1 = 4. 42 and log beta 2 = 8. 57 were obtained.", "output": {"entities": {}}, "schema": []}
{"input": "Cryopreservation straws filled with media plus additive are emersed below the surface of an unprocessed donor ejaculate.", "output": {"entities": {}}, "schema": []}
{"input": "The bcl-2 gene can potentially encode 26-and 22-kDa proteins that differ only in their carboxyl tails because of an alternative splicing mechanism.", "output": {"entities": {"gene": [{"text": "bcl-2 gene", "start": 4, "end": 14}]}}, "schema": []}
{"input": "The active open reading frame in the clone maps at 27 min on the E. coli chromosome and is identical in sequence to a wild type counterpart.", "output": {"entities": {}}, "schema": []}
{"input": "Subsequent cloning and nucleotide sequence analysis of the S. pombe adenylate kinase gene, adk1, revealed a coding region of 660 nucleotides.", "output": {"entities": {"gene": [{"text": "S. pombe adenylate kinase gene", "start": 59, "end": 89}, {"text": "adk1", "start": 91, "end": 95}]}}, "schema": []}
{"input": "As a result of alternative splicing, the BGP gene is transcribed into at least seven distinct mRNA species.", "output": {"entities": {"gene": [{"text": "BGP gene", "start": 41, "end": 49}]}}, "schema": []}
{"input": "However, essential contrast differences existing between the FSE sequences and their routine asymmetric dual SE counterpart can be identified.", "output": {"entities": {}}, "schema": []}
{"input": "The level of the SUP4A53T61 transcript was threefold higher in the tap1-1 mutant than in the wild type.", "output": {"entities": {"gene": [{"text": "SUP4A53T61 transcript", "start": 17, "end": 38}, {"text": "tap1-1 mutant", "start": 67, "end": 80}]}}, "schema": []}
{"input": "This sequence similarity raises the possibility that GCN1 interacts with ribosomes or tRNA molecules and functions in conjunction with GCN2 in monitoring uncharged tRNA levels during the process of translation elongation.", "output": {"entities": {"gene": [{"text": "GCN1", "start": 53, "end": 57}, {"text": "GCN2", "start": 135, "end": 139}]}}, "schema": []}
{"input": "NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3' alpha enhancer at early stages of B-cell differentiation.", "output": {"entities": {"gene": [{"text": "NF-HB", "start": 0, "end": 5}, {"text": "BSAP", "start": 7, "end": 11}, {"text": "murine immunoglobulin heavy-chain 3' alpha enhancer", "start": 35, "end": 86}]}}, "schema": []}
{"input": "In conclusion, changes in carotid sinus stimulation alters blood flow to the hindlimb through changes in both Pcrit and Ra.", "output": {"entities": {}}, "schema": []}
{"input": "Multizone PRK has been suggested to increase the predictability of higher myopic corrections.", "output": {"entities": {}}, "schema": []}
{"input": "In 17 patients with deletions, the parental origin of deletion was determined.", "output": {"entities": {}}, "schema": []}
{"input": "The COL7A1 gene, which encodes type VII collagen, has been implicated as a candidate gene for dominantly and recessively inherited forms of dystrophic epidermolysis bullosa.", "output": {"entities": {"gene": [{"text": "COL7A1 gene", "start": 4, "end": 15}, {"text": "type VII collagen", "start": 31, "end": 48}]}}, "schema": []}
{"input": "However, study of the productive gamma gene showed that the skipped variable exon was bounded by normal splicing signals and that the adjacent intron organization was not altered.", "output": {"entities": {}}, "schema": []}
{"input": "We conclude that grade III BGCT can be treated by modified intralesional excision provided the articular surfaces and part of the metaphysis are intact.", "output": {"entities": {}}, "schema": []}
{"input": "Second, nitrate induction of aeg-46. 5 operon expression is substantially enhanced in narL null strains (M. H.", "output": {"entities": {"gene": [{"text": "aeg-46. 5 operon", "start": 29, "end": 45}, {"text": "narL", "start": 86, "end": 90}]}}, "schema": []}
{"input": "This new knowledge has contributed to the development of a successful immunoprophylactic strategy for eliminating Hib disease.", "output": {"entities": {}}, "schema": []}
{"input": "The HMG CoA reductase inhibitors are the most effective cholesterol-lowering agents currently available.", "output": {"entities": {"gene": [{"text": "HMG CoA reductase", "start": 4, "end": 21}]}}, "schema": []}
{"input": "The etiology, pathology, brain CT scan features, clinical manifestations and treatment of these accidents were discussed.", "output": {"entities": {}}, "schema": []}
{"input": "Drosophila 230-kD TFIID subunit, a functional homolog of the human cell cycle gene product, negatively regulates DNA binding of the TATA box-binding subunit of TFIID.", "output": {"entities": {"gene": [{"text": "TFIID", "start": 18, "end": 23}, {"text": "TATA box-binding subunit of TFIID", "start": 132, "end": 165}]}}, "schema": []}
{"input": "One enigmatic aspect of GATA factor expression is that several GATA proteins, which ostensibly share the same DNA-binding site specificity, are coexpressed in erythroid cells.", "output": {"entities": {"gene": [{"text": "GATA factor", "start": 24, "end": 35}, {"text": "GATA proteins", "start": 63, "end": 76}]}}, "schema": []}
{"input": "Pit-1 is a tissue-specific POU domain factor obligatory for the appearance of three cell phenotypes in the anterior pituitary gland.", "output": {"entities": {"gene": [{"text": "Pit-1", "start": 0, "end": 5}, {"text": "POU domain factor", "start": 27, "end": 44}]}}, "schema": []}
{"input": "Maximum number of strains (39. 1%) were resistant in S. bareilly serotype, followed by S. typhimurium (21. 7%) and least in S. typhi (17. 4%).", "output": {"entities": {}}, "schema": []}
{"input": "Characterization and hormonal regulation of the promoter of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells.", "output": {"entities": {"gene": [{"text": "rat prostaglandin endoperoxide synthase 2 gene", "start": 64, "end": 110}]}}, "schema": []}
{"input": "The retention of 75SeHCAT was low.", "output": {"entities": {}}, "schema": []}
{"input": "Members of the C/EBP family of basic-leucine zipper (bZip) transcription factors form heterodimers and bind to the CAAT box and other sequence-related enhancer motifs.", "output": {"entities": {"gene": [{"text": "C/EBP family", "start": 15, "end": 27}, {"text": "basic-leucine zipper (bZip) transcription factors", "start": 31, "end": 80}]}}, "schema": []}
{"input": "In mammalian cells, phosphorylation of eIF-2 alpha inhibits the activity of eIF-2B, the GDP-GTP exchange factor for eIF-2.", "output": {"entities": {"gene": [{"text": "eIF-2 alpha", "start": 39, "end": 50}, {"text": "eIF-2B", "start": 76, "end": 82}, {"text": "GDP-GTP exchange factor", "start": 88, "end": 111}, {"text": "eIF-2", "start": 116, "end": 121}]}}, "schema": []}
{"input": "In conclusion, these observations demonstrated that stratification of acute MI patients by plasma ANF level is a useful non-invasive method for predicting prognosis and for identifying individuals at high risk of cardiac death.", "output": {"entities": {"gene": [{"text": "ANF", "start": 98, "end": 101}]}}, "schema": []}
{"input": "Analysis of the binding of Lrp to a set of circularly permuted DNA fragments from this region indicates that Lrp induces DNA bending.", "output": {"entities": {"gene": [{"text": "Lrp", "start": 27, "end": 30}, {"text": "Lrp", "start": 109, "end": 112}]}}, "schema": []}
{"input": "Seven out of 34 patients died, giving a mortality rate of 21%.", "output": {"entities": {}}, "schema": []}
{"input": "A 36-kDa protein that was localized to the membrane fraction was detected in minicells containing plasmids with the ftsN gene, confirming that FtsN was a membrane protein.", "output": {"entities": {"gene": [{"text": "ftsN gene", "start": 116, "end": 125}, {"text": "FtsN", "start": 143, "end": 147}]}}, "schema": []}
{"input": "SSG1, a gene encoding a sporulation-specific 1, 3-beta-glucanase in Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "SSG1", "start": 0, "end": 4}, {"text": "sporulation-specific 1, 3-beta-glucanase", "start": 24, "end": 64}]}}, "schema": []}
{"input": "Expression of this protein in E. coli demonstrated that tyrosine was incorporated during suppression and that yeast cytoplasmic TyrRS activity was produced.", "output": {"entities": {"gene": [{"text": "yeast cytoplasmic TyrRS", "start": 110, "end": 133}]}}, "schema": []}
{"input": "The first involved complementation of a nonphotosynthetic mutant of Chlamydomonas, CC-2341 (ac-u-g-2. 3), which has a frameshift mutation in the psaB gene, and selection of photosynthetic transformants on minimal medium.", "output": {"entities": {"gene": [{"text": "psaB gene", "start": 145, "end": 154}]}}, "schema": []}
{"input": "Against 200 strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated from 1990 to 1991, minimum inhibitory concentrations (MICs) of a total of 15 antibacterial agents including arbekacin (ABK) were determined.", "output": {"entities": {}}, "schema": []}
{"input": "It is reported that, at present, most of the MRSAs spreading in Japan are acceleratedly acquiring resistance to many drugs, and especially, they are developing high resistance against beta-lactams.", "output": {"entities": {}}, "schema": []}
{"input": "Beg2 and Beg1 are regulated differently which may indicate variation in storage or utilization properties among the barley globulins.", "output": {"entities": {"gene": [{"text": "Beg2", "start": 0, "end": 4}, {"text": "Beg1", "start": 9, "end": 13}, {"text": "barley globulins", "start": 116, "end": 132}]}}, "schema": []}
{"input": "Here, we have more closely investigated transactivation of the human HSP70 promoter by Myb proteins.", "output": {"entities": {"gene": [{"text": "human HSP70 promoter", "start": 63, "end": 83}, {"text": "Myb proteins", "start": 87, "end": 99}]}}, "schema": []}
{"input": "We have found out that one-year-old carps are extremely sensitive to ichthiomycin in concentrations between 25-125 micrograms/dm3.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: Statistically significant differences were obtained between group I and II concerning the number of patients in whom induced atrial fibrillation with conduction by the accessory pathway and RR < or = 250 msec was found (0 vs 6, p = 0. 0045).", "output": {"entities": {}}, "schema": []}
{"input": "We studied the effect of skinfold thickness on the correlation between serum total bilirubin level and transcutaneous bilirubin (TcB) readings.", "output": {"entities": {}}, "schema": []}
{"input": "The GTPase activity of CDC42Ce is moderately stimulated by human n-chimaerin, a GTPase-activating protein for the related p21 rac1.", "output": {"entities": {"gene": [{"text": "GTPase", "start": 4, "end": 10}, {"text": "CDC42Ce", "start": 23, "end": 30}, {"text": "human n-chimaerin", "start": 59, "end": 76}, {"text": "GTPase-activating protein", "start": 80, "end": 105}, {"text": "p21 rac1", "start": 122, "end": 130}]}}, "schema": []}
{"input": "Tl-201 uptake ratio of the right ventricle, which represents the ratio of total counts of the right ventricle to counts of the administered dose of Tl-201, was higher in COPD, especially in pulmonary emphysema and B type COPD by Burrows classification than in controls.", "output": {"entities": {}}, "schema": []}
{"input": "A second hydrophobic domain, bordered by two hydrophilic regions strongly suggests a transmembrane region.", "output": {"entities": {}}, "schema": []}
{"input": "This gene spans 23 kb and is composed of five exons and four introns.", "output": {"entities": {}}, "schema": []}
{"input": "The remaining RAD + cells progressed to form microcolonies (< 30 cells) containing aberrantly shaped inviable cells.", "output": {"entities": {"gene": [{"text": "RAD +", "start": 14, "end": 19}]}}, "schema": []}
{"input": "The 11; 22 chromosomal translocation specifically linked to Ewing sarcoma and primitive neuroectodermal tumor results in a chimeric molecule fusing the amino-terminal-encoding portion of the EWS gene to the carboxyl-terminal DNA-binding domain encoded by the FLI1 gene.", "output": {"entities": {"gene": [{"text": "EWS gene", "start": 191, "end": 199}, {"text": "FLI1 gene", "start": 259, "end": 268}]}}, "schema": []}
{"input": "These findings suggest that a range of microenvironmental conditions exist within purified water systems, leading to variable populations of bacteria.", "output": {"entities": {}}, "schema": []}
{"input": "X-linked liver glycogenosis: localization and isolation of a candidate gene.", "output": {"entities": {}}, "schema": []}
{"input": "This conclusion is based on the observations of the immunologic changes that characterize the acute stages of illness as well as on the demonstrated association with toxin-producing bacteria in the pharynx and gastrointestinal tract.", "output": {"entities": {}}, "schema": []}
{"input": "Measurement of anti-HCV IgM antibodies with an experimental kit", "output": {"entities": {"gene": [{"text": "anti-HCV IgM antibodies", "start": 15, "end": 38}]}}, "schema": []}
{"input": "Embryo coculture system may contribute to understand the mechanisms underlying the decrease of fertility with aging.", "output": {"entities": {}}, "schema": []}
{"input": "These cell lines displayed methylation of the CpG island surrounding the first exon of p16INK4A and expressed abundant levels of a nontranslated mRNA containing an alternative first exon (E1 beta), as did all other cell lines in which the p16INK4A locus was not deleted.", "output": {"entities": {"gene": [{"text": "p16INK4A", "start": 87, "end": 95}, {"text": "p16INK4A locus", "start": 239, "end": 253}]}}, "schema": []}
{"input": "An immunoperoxidase reaction, PAP method, with the antiserum of Factor VIII as the primary antibody, was carried out in the endometrial biopsies to detect the Factor VIII activity in the endometrial endothelium before and after insertion of LNG-IUD-20.", "output": {"entities": {"gene": [{"text": "immunoperoxidase", "start": 3, "end": 19}, {"text": "PAP", "start": 30, "end": 33}, {"text": "Factor VIII", "start": 64, "end": 75}, {"text": "Factor VIII", "start": 159, "end": 170}]}}, "schema": []}
{"input": "Egd1p is homologous to human BTF3b, recently identified as the beta subunit of the heterodimeric nascent-polypeptide-associated complex (NAC) involved in ensuring signal-sequence-specific protein sorting and translocation [Wiedmann et al., Nature 370 (1994) 434-440].", "output": {"entities": {"gene": [{"text": "Egd1p", "start": 0, "end": 5}, {"text": "human BTF3b", "start": 23, "end": 34}, {"text": "heterodimeric nascent-polypeptide-associated complex", "start": 83, "end": 135}, {"text": "NAC", "start": 137, "end": 140}]}}, "schema": []}
{"input": "Purified PLB showed optimal lyase activity at pH 10. 0.", "output": {"entities": {"gene": [{"text": "PLB", "start": 9, "end": 12}, {"text": "lyase", "start": 28, "end": 33}]}}, "schema": []}
{"input": "The 5' flanking regions of both pelA and pelB were translationally fused to the beta-glucuronidase gene and introduced into F. solani f. sp. pisi, and beta-glucuronidase activities of the transformants were measured.", "output": {"entities": {"gene": [{"text": "pelA", "start": 32, "end": 36}, {"text": "pelB", "start": 41, "end": 45}, {"text": "beta-glucuronidase gene", "start": 80, "end": 103}, {"text": "beta-glucuronidase", "start": 151, "end": 169}]}}, "schema": []}
{"input": "When nifA mRNA 5' start points were mapped by primer extension, both a minor upstream transcript (s) starting 45 bp distal to the anaerobox and a major downstream transcript starting 10 bp distal to the sigma 54 box were observed.", "output": {"entities": {"gene": [{"text": "nifA mRNA", "start": 5, "end": 14}, {"text": "sigma 54", "start": 203, "end": 211}]}}, "schema": []}
{"input": "We failed to find these data to be useful in predicting the time of onset of initial seizures after acute ischemic stroke and recurrence.", "output": {"entities": {}}, "schema": []}
{"input": "The human papillomavirus type 16 E7 protein complements adenovirus type 5 E1A amino-terminus-dependent transactivation of adenovirus type 5 early genes and increases ATF and Oct-1 DNA binding activity.", "output": {"entities": {"gene": [{"text": "human papillomavirus type 16 E7 protein", "start": 4, "end": 43}, {"text": "adenovirus type 5 E1A", "start": 56, "end": 77}, {"text": "adenovirus type 5 early genes", "start": 122, "end": 151}, {"text": "ATF", "start": 166, "end": 169}, {"text": "Oct-1", "start": 174, "end": 179}]}}, "schema": []}
{"input": "A chaotropic detergent, 0. 1% Nonidet P-40, also abolished the interaction, further supporting the hydrophobic nature of the interaction.", "output": {"entities": {}}, "schema": []}
{"input": "Degradation of the soybean ribulose-1, 5-bisphosphate carboxylase small-subunit mRNA, SRS4, initiates with endonucleolytic cleavage.", "output": {"entities": {"gene": [{"text": "soybean ribulose-1, 5-bisphosphate carboxylase small-subunit mRNA", "start": 19, "end": 84}, {"text": "SRS4", "start": 86, "end": 90}]}}, "schema": []}
{"input": "Cloning and sequencing revealed that dMax contains a deletion spanning the basic region and helix 1 and the loop of the helix-loop-helix region, presumably as a result of alternative splicing of max RNA.", "output": {"entities": {"gene": [{"text": "dMax", "start": 37, "end": 41}, {"text": "max RNA", "start": 195, "end": 202}]}}, "schema": []}
{"input": "The domain structure of bovine LTBP-2 is very similar to that of the human LTBP-2, containing 20 examples of 6-cysteine epidermal growth factor-like repeats, 16 of which have the consensus sequence for calcium binding, together with 4 examples of 8-cysteine motifs characteristic of fibrillins and LTBP-1.", "output": {"entities": {"gene": [{"text": "bovine LTBP-2", "start": 24, "end": 37}, {"text": "human LTBP-2", "start": 69, "end": 81}, {"text": "epidermal growth factor-like repeats", "start": 120, "end": 156}, {"text": "fibrillins", "start": 283, "end": 293}, {"text": "LTBP-1", "start": 298, "end": 304}]}}, "schema": []}
{"input": "Similarly, expression of a transiently transfected wild-type prothymosin alpha gene as the reporter was not affected by a repertoire of myc-derived genes, including myc itself and dominant or recessive negative myc mutants.", "output": {"entities": {"gene": [{"text": "wild-type prothymosin alpha gene", "start": 51, "end": 83}, {"text": "myc-derived genes", "start": 136, "end": 153}, {"text": "myc", "start": 165, "end": 168}, {"text": "myc mutants", "start": 211, "end": 222}]}}, "schema": []}
{"input": "Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1.", "output": {"entities": {"gene": [{"text": "alpha/beta interferon", "start": 31, "end": 52}, {"text": "Jak", "start": 64, "end": 67}, {"text": "Stat", "start": 68, "end": 72}, {"text": "SH2", "start": 88, "end": 91}, {"text": "tyrosine phosphatase SHPTP1", "start": 110, "end": 137}]}}, "schema": []}
{"input": "We now report the isolation and expression of cDNAs encoding PTF gamma and PTF delta, as well as functional studies with cognate antibodies that recognize the native PTF complex in HeLa extracts.", "output": {"entities": {"gene": [{"text": "PTF gamma", "start": 61, "end": 70}, {"text": "PTF delta", "start": 75, "end": 84}, {"text": "PTF complex", "start": 166, "end": 177}]}}, "schema": []}
{"input": "Results from the mechanism study have revealed that YY1 is able to inhibit transactivation mediated by either AP1 or the Sp1-related protein, and YY1 suppressive activity is DNA binding dependent.", "output": {"entities": {"gene": [{"text": "YY1", "start": 52, "end": 55}, {"text": "AP1", "start": 110, "end": 113}, {"text": "Sp1-related protein", "start": 121, "end": 140}, {"text": "YY1", "start": 146, "end": 149}]}}, "schema": []}
{"input": "The skp1 + gene is not essential.", "output": {"entities": {"gene": [{"text": "skp1 + gene", "start": 4, "end": 15}]}}, "schema": []}
{"input": "The TEA1 (Ty enhancer activator) gene sequence predicts a protein of 86. 9 kDa whose N terminus contains a zinc cluster and dimerization motif typical of the Gal4-type family of DNA-binding proteins.", "output": {"entities": {"gene": [{"text": "TEA1", "start": 4, "end": 8}, {"text": "Ty enhancer activator", "start": 10, "end": 31}, {"text": "Gal4-type family", "start": 158, "end": 174}]}}, "schema": []}
{"input": "Videonystagmoscopy has been used to subjectively observe the responses of the vestibular system in a population of patients with vestibular deficits.", "output": {"entities": {}}, "schema": []}
{"input": "The MCA and UA PI values showed the greatest deviation for any single-vessel parameter.", "output": {"entities": {}}, "schema": []}
{"input": "Stems contain distinctly less P protein mRNA and the relative level in roots is very low but still clearly detectable.", "output": {"entities": {"gene": [{"text": "P protein mRNA", "start": 30, "end": 44}]}}, "schema": []}
{"input": "The B. germanica cyclophilin amino acid sequence shares 83% identity with the cytosolic cyclophilin isoform from Drosophila melanogaster (Cyp-1).", "output": {"entities": {"gene": [{"text": "B. germanica cyclophilin amino acid sequence", "start": 4, "end": 48}, {"text": "cytosolic cyclophilin isoform from Drosophila melanogaster", "start": 78, "end": 136}, {"text": "Cyp-1", "start": 138, "end": 143}]}}, "schema": []}
{"input": "The minimal region of overlap of Langer-Giedion syndrome deletions, previously identified by analysis of 15 patients, was placed on the map by analysis of 2 patients whose deletions define the endpoints.", "output": {"entities": {}}, "schema": []}
{"input": "Comparison of promoters repressed by c-myc reveals a weak consensus sequence of the initiator (Inr) element: TCA (+ 1) YYYNY.", "output": {"entities": {"gene": [{"text": "c-myc", "start": 37, "end": 42}]}}, "schema": []}
{"input": "The human gp39 promoter.", "output": {"entities": {"gene": [{"text": "human gp39 promoter", "start": 4, "end": 23}]}}, "schema": []}
{"input": "Transfection analyses indicate that mutation of any one of these TGACCT motifs or truncation of the entire HD PPRE into a separate DR1 and DR2 element significantly reduced the transcriptional response of HD PPRE to peroxisome proliferators.", "output": {"entities": {"gene": [{"text": "HD", "start": 107, "end": 109}, {"text": "HD", "start": 205, "end": 207}]}}, "schema": []}
{"input": "The site of autophosphorylation is Tyr397 which corresponds to the consensus autophosphorylation site of other Src family tyrosine kinases.", "output": {"entities": {"gene": [{"text": "Src family tyrosine kinases", "start": 111, "end": 138}]}}, "schema": []}
{"input": "This protein-protein interaction does not require the simultaneous binding of Oct proteins to DNA, and high resolution footprinting of the Oct-DNA interaction reveals that binding of BOB. 1/OBF. 1 to Oct1 or Oct2 does not alter the interaction with DNA.", "output": {"entities": {"gene": [{"text": "Oct proteins", "start": 78, "end": 90}, {"text": "Oct-DNA", "start": 139, "end": 146}, {"text": "BOB. 1", "start": 183, "end": 189}, {"text": "OBF. 1", "start": 190, "end": 196}, {"text": "Oct1", "start": 200, "end": 204}, {"text": "Oct2", "start": 208, "end": 212}]}}, "schema": []}
{"input": "Together, our data suggest that the TR2 orphan receptor may be a master regulator in modulating the activation of two key HREs, RARE beta and CRBPIIp, involved in the retinoic acid signal transduction pathway.", "output": {"entities": {"gene": [{"text": "TR2 orphan receptor", "start": 36, "end": 55}]}}, "schema": []}
{"input": "Using a series of mutant proteins, we have characterized domains responsible for activation or repression.", "output": {"entities": {}}, "schema": []}
{"input": "It is considered that the recurrent annular erythema is a specific skin manifestation of SjS with anti SS-A/SS-B antibodies.", "output": {"entities": {"gene": [{"text": "anti SS-A", "start": 98, "end": 107}, {"text": "SS-B antibodies", "start": 108, "end": 123}]}}, "schema": []}
{"input": "Competition needs to be better studied, since in Central America and Caribean islands this kind of study has favored the biological control of planorbid species.", "output": {"entities": {}}, "schema": []}
{"input": "In this paper we describe properties of the cdc10-C4 mutant of the fission yeast Schizosaccharomyces pombe.", "output": {"entities": {"gene": [{"text": "cdc10", "start": 44, "end": 49}]}}, "schema": []}
{"input": "TIEG expression in hFOB cells was highly induced by TGF-beta and bone morphogenetic protein-2 (BMP-2), with a moderate induction by epidermal growth factor (EGF), but no induction by other growth factors/cytokines was observed.", "output": {"entities": {"gene": [{"text": "TIEG", "start": 0, "end": 4}, {"text": "TGF-beta", "start": 52, "end": 60}, {"text": "bone morphogenetic protein-2", "start": 65, "end": 93}, {"text": "BMP-2", "start": 95, "end": 100}, {"text": "epidermal growth factor", "start": 132, "end": 155}, {"text": "EGF", "start": 157, "end": 160}]}}, "schema": []}
{"input": "The predicted protein products of ORFs N2417 and N2403 present similarities with domains from proteins of other organisms: the Candida maltosa cycloheximide-resistance protein, the human interleukin enhancer-binding factor (ILF-2).", "output": {"entities": {"gene": [{"text": "ORFs N2417", "start": 34, "end": 44}, {"text": "N2403", "start": 49, "end": 54}, {"text": "cycloheximide-resistance protein", "start": 143, "end": 175}, {"text": "interleukin enhancer-binding factor", "start": 187, "end": 222}, {"text": "ILF-2", "start": 224, "end": 229}]}}, "schema": []}
{"input": "In particular, the highly expressed ADH1 gene is represented in this database by no less than 20 EST sequences.", "output": {"entities": {"gene": [{"text": "ADH1 gene", "start": 36, "end": 45}]}}, "schema": []}
{"input": "Five families of Ashkenazi Jewish descent carried the 185delAG mutation and shared the same haplotype at eight polymorphic markers spanning approximately 850 kb at BRCA1.", "output": {"entities": {"gene": [{"text": "BRCA1", "start": 164, "end": 169}]}}, "schema": []}
{"input": "The subjects from the two regions with a higher pollution level had lower FVC and FEV1 values than those from the Viskovo region.", "output": {"entities": {}}, "schema": []}
{"input": "PTP-S3 differs from PTP-S4 in having a deletion of 19 amino acids corresponding to exon E1.", "output": {"entities": {"gene": [{"text": "PTP-S3", "start": 0, "end": 6}, {"text": "PTP-S4", "start": 20, "end": 26}]}}, "schema": []}
{"input": "When differentiated G0-arrested leaf cells were induced to resume cell division by treatment with plant hormones, cycMs4 transcription was induced before the onset of DNA synthesis.", "output": {"entities": {"gene": [{"text": "cycMs4", "start": 114, "end": 120}]}}, "schema": []}
{"input": "A survey is given of the pharmacological backgrounds that are relevant for the drug treatment of essential hypertension in the elderly.", "output": {"entities": {}}, "schema": []}
{"input": "Protein kinases play pivotal roles in the control of many cellular processes.", "output": {"entities": {}}, "schema": []}
{"input": "Interestingly, internal and 5' deletions revealed tha the distal promoter was not required for full transcriptional activity and that the first 631 base pairs of WNT-5A harbored the strongest promoter activity.", "output": {"entities": {"gene": [{"text": "WNT-5A", "start": 162, "end": 168}]}}, "schema": []}
{"input": "The protein kinase domains of LIMK1 and LIMK2 are unique in that they contain an unusual sequence motif Asp-Leu-Asn-Ser-His-Asn in subdomain VIB and a highly basic insert between subdomains VII and VIII.", "output": {"entities": {"gene": [{"text": "LIMK1", "start": 30, "end": 35}, {"text": "LIMK2", "start": 40, "end": 45}]}}, "schema": []}
{"input": "A human recombinant cDNA clone that encoded 253 amino acids residues of a zinc-finger protein (THZif-1) was cloned by screening a cDNA library prepared from human promyelocytic leukemia HL60 cells with synthetic oligodeoxynucleotide probes that corresponded to the amino acid sequences of tryptic peptides derived from the DNA-binding protein specific for the nuclease-hypersensitive element (NHE) of the human c-myc gene.", "output": {"entities": {"gene": [{"text": "zinc-finger protein", "start": 74, "end": 93}, {"text": "THZif-1", "start": 95, "end": 102}, {"text": "nuclease-hypersensitive element", "start": 360, "end": 391}, {"text": "NHE", "start": 393, "end": 396}, {"text": "human c-myc gene", "start": 405, "end": 421}]}}, "schema": []}
{"input": "Erythrocyte AA in FO + EPO-supplemented infants remained low and below breast-and placebo formula-fed levels.", "output": {"entities": {"gene": [{"text": "EPO", "start": 23, "end": 26}]}}, "schema": []}
{"input": "Taking into consideration weight and seasonal changes in bone mass, total (TBBMC) and regional body bone mineral content were measured in 38 women treated with GnRH agonists for 6 months for endometriosis or leiomyomata.", "output": {"entities": {"gene": [{"text": "GnRH", "start": 160, "end": 164}]}}, "schema": []}
{"input": "The encoded polypeptide is similar in sequence to the ABA-1 allergen of Ascaris, the gp15/400' ladder' protein of Brugia malayi, Brugia pahangi and Wuchereria bancrofti, and a 15-kDa antigen of Dirofilaria immitis.", "output": {"entities": {"gene": [{"text": "ABA-1 allergen of Ascaris", "start": 54, "end": 79}, {"text": "gp15/400' ladder' protein of Brugia malayi, Brugia pahangi and Wuchereria bancrofti", "start": 85, "end": 168}, {"text": "15-kDa antigen of Dirofilaria immitis", "start": 176, "end": 213}]}}, "schema": []}
{"input": "Spontaneous recovery occurs within 30 min to 2 hrs.", "output": {"entities": {}}, "schema": []}
{"input": "DAF is a 70 kD glycoprotein containing complement regulatory short consensus repeats (SCRs); its gene is located in the regulation of complement activation (RCA) gene cluster on chromosome 1 and is about 40 kb in size.", "output": {"entities": {"gene": [{"text": "DAF", "start": 0, "end": 3}, {"text": "regulation of complement activation", "start": 120, "end": 155}, {"text": "RCA", "start": 157, "end": 160}]}}, "schema": []}
{"input": "There is no TATA box around the transcriptional start points (tsp), as determined by primer extension analysis.", "output": {"entities": {}}, "schema": []}
{"input": "According to the investigation, the recent burst of pseudoterranovosis in this area can be attributed to the increased presence of sea lions, which proliferate in the Arctic region, then migrate to the northern Japan Sea and eat the intermediate host fish.", "output": {"entities": {}}, "schema": []}
{"input": "In summary, the efficacies of adjuvant carboplatin and of abdominal radiotherapy seem to be identical.", "output": {"entities": {}}, "schema": []}
{"input": "To identify some of the genes expressed in LPS-activated coelomocytes, we sequenced randomly chosen clones from a directionally constructed cDNA library to produce a set of expressed sequence tags (ESTs).", "output": {"entities": {}}, "schema": []}
{"input": "Characterization of an EcR/USP heterodimer target site that mediates ecdysone responsiveness of the Drosophila Lsp-2 gene.", "output": {"entities": {"gene": [{"text": "EcR", "start": 23, "end": 26}, {"text": "USP", "start": 27, "end": 30}, {"text": "Drosophila Lsp-2 gene", "start": 100, "end": 121}]}}, "schema": []}
{"input": "Thus, SPECT was not as sensitive as PET in this activation task.", "output": {"entities": {}}, "schema": []}
{"input": "Transcriptional activation of the chicken lysozyme gene by NF-kappa Bp65 (RelA) and c-Rel, but not by NF-kappa Bp50.", "output": {"entities": {"gene": [{"text": "chicken lysozyme gene", "start": 34, "end": 55}, {"text": "NF-kappa Bp65", "start": 59, "end": 72}, {"text": "RelA", "start": 74, "end": 78}, {"text": "c-Rel", "start": 84, "end": 89}, {"text": "NF-kappa Bp50", "start": 102, "end": 115}]}}, "schema": []}
{"input": "The results indicate that the bradycardic agents alinidine and zatebradine do not exert antiarrhythmic efficacy against SVT induced during subacute myocardial infarction in conscious dogs.", "output": {"entities": {}}, "schema": []}
{"input": "In vivo, selective activation of SAPKs stimulates formation of the ternary complex containing Elk-1, serum response factor and the serum response element, and enhances Elk-1-dependent transcription.", "output": {"entities": {"gene": [{"text": "SAPKs", "start": 33, "end": 38}, {"text": "Elk-1", "start": 94, "end": 99}, {"text": "serum response factor", "start": 101, "end": 122}, {"text": "Elk-1", "start": 168, "end": 173}]}}, "schema": []}
{"input": "An epidemic of hepatitis B virus infection among intravenous drug users in Iceland.", "output": {"entities": {}}, "schema": []}
{"input": "Three of these subunits are also homologous to the dimeric POR from a mesophilic archaeon, Halobacterium halobium (21% identity).", "output": {"entities": {"gene": [{"text": "POR", "start": 59, "end": 62}]}}, "schema": []}
{"input": "The transposon-inactivated gene, designated pilP, is 525 bp long, potentially encoding a 19. 1-kDa protein precursor that contains a typical membrane lipoprotein leader sequence.", "output": {"entities": {"gene": [{"text": "pilP", "start": 44, "end": 48}]}}, "schema": []}
{"input": "Cheung and S.", "output": {"entities": {}}, "schema": []}
{"input": "Upstream of the dra gene an open reading frame of 313 amino acids was identified.", "output": {"entities": {"gene": [{"text": "dra gene", "start": 16, "end": 24}]}}, "schema": []}
{"input": "Sucrose-specific regulation of scrB was also lost upon deletion of 4 bp of a palindromic sequence (OB) covering positions + 6 to + 21 downstream of the scrB transcriptional start site.", "output": {"entities": {"gene": [{"text": "scrB", "start": 31, "end": 35}, {"text": "scrB", "start": 152, "end": 156}]}}, "schema": []}
{"input": "In E. coli, CheW mediates the physical coupling of the receptors to the kinase CheA.", "output": {"entities": {"gene": [{"text": "CheW", "start": 12, "end": 16}, {"text": "CheA", "start": 79, "end": 83}]}}, "schema": []}
{"input": "The promoter of the first gene, epiF, responded to the activator protein EpiQ and contained a palindromic sequence similar to the EpiQ binding site of the epiA promoter, which is also activated by EpiQ.", "output": {"entities": {"gene": [{"text": "epiF", "start": 32, "end": 36}, {"text": "activator protein EpiQ", "start": 55, "end": 77}, {"text": "EpiQ binding site", "start": 130, "end": 147}, {"text": "epiA promoter", "start": 155, "end": 168}, {"text": "EpiQ", "start": 197, "end": 201}]}}, "schema": []}
{"input": "CXC chemokines bind to unique sets of selectivity determinants that can function independently and are broadly distributed on multiple domains of human interleukin-8 receptor B.", "output": {"entities": {"gene": [{"text": "interleukin-8 receptor B", "start": 152, "end": 176}]}}, "schema": []}
{"input": "Oligodeoxynucleotides antisense to the predicted translation initiation regions of ICP4 and pp38 mRNAs inhibited proliferation of MSB1 cells but not MDCC-CU91 (CU91) reticuloendotheliosis virus-transformed cells.", "output": {"entities": {"gene": [{"text": "ICP4", "start": 83, "end": 87}, {"text": "pp38 mRNAs", "start": 92, "end": 102}]}}, "schema": []}
{"input": "Retroviral replication requires that a portion of the primary transcripts generated from proviral DNA be spliced to serve as mRNA for the envelope protein and in Rous sarcoma virus as src mRNA.", "output": {"entities": {"gene": [{"text": "envelope protein", "start": 138, "end": 154}, {"text": "src mRNA", "start": 184, "end": 192}]}}, "schema": []}
{"input": "In this case the degree of promoter methylation, which could extend beyond the T-DNA borders, was not correlated with the reduction in steady-state poly (A) + mRNA levels, the silenced state was transmitted through meiosis and reactivation lasted several generations.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, the consensus sequences for phosphatase regulation are 5'-GCACGTGGG-3' and 5'-GCACGTTTT-3' which differ from the binding sequences for the Cpflp protein required for transcription of the genes in methionine biosynthesis and for centromere function.", "output": {"entities": {"gene": [{"text": "Cpflp", "start": 145, "end": 150}]}}, "schema": []}
{"input": "Here we report that the proline-rich region of CAP is recognized by the SH3 domains of several proteins, including the yeast actin-associated protein Abp1p.", "output": {"entities": {"gene": [{"text": "CAP", "start": 47, "end": 50}, {"text": "SH3 domains", "start": 72, "end": 83}, {"text": "yeast actin-associated protein Abp1p", "start": 119, "end": 155}]}}, "schema": []}
{"input": "We have identified and characterized a vitamin D response element (VDRE) in the promoter of c-fos.", "output": {"entities": {"gene": [{"text": "c-fos", "start": 92, "end": 97}]}}, "schema": []}
{"input": "In addition to protein binding at sequences known to be involved in the regulation of transcription, genomic footprinting of the entire promoter region also showed that a protein factor is constitutively bound to the first intron of the rep3 gene.", "output": {"entities": {"gene": [{"text": "rep3 gene", "start": 237, "end": 246}]}}, "schema": []}
{"input": "Differentiation was not observed after cellular expression of GTPase-deficient forms of alpha i2 or alpha 0, indicating selectivity for the Gq family of G proteins.", "output": {"entities": {"gene": [{"text": "GTPase", "start": 62, "end": 68}, {"text": "alpha i2", "start": 88, "end": 96}, {"text": "alpha 0", "start": 100, "end": 107}, {"text": "Gq family", "start": 140, "end": 149}, {"text": "G proteins", "start": 153, "end": 163}]}}, "schema": []}
{"input": "Consistent with a possible role in transcription, Paf1p is localized to the nucleus.", "output": {"entities": {"gene": [{"text": "Paf1p", "start": 50, "end": 55}]}}, "schema": []}
{"input": "By comparing the abundances of many yeast transcripts in isogenic wild-type and paf1 mutant strains, we have identified genes whose expression is affected by PAF1.", "output": {"entities": {"gene": [{"text": "paf1 mutant", "start": 80, "end": 91}, {"text": "PAF1", "start": 158, "end": 162}]}}, "schema": []}
{"input": "Paf1p may therefore be required for both positive and negative regulation of subsets of yeast genes.", "output": {"entities": {"gene": [{"text": "Paf1p", "start": 0, "end": 5}]}}, "schema": []}
{"input": "Using a high-copy suppression strategy, we have identified a yeast gene (UBS1) whose elevated expression suppresses the conditional cell cycle defects associated with cdc34 mutations.", "output": {"entities": {"gene": [{"text": "UBS1", "start": 73, "end": 77}, {"text": "cdc34", "start": 167, "end": 172}]}}, "schema": []}
{"input": "Molecular characterization of malignant melanoma of soft parts or soft tissue clear cell sarcoma which shares t (12; 22) chromosome translocation revealed fusion of EWS with a transcriptional factor gene ATF-1.", "output": {"entities": {"gene": [{"text": "EWS", "start": 165, "end": 168}, {"text": "gene ATF-1", "start": 199, "end": 209}]}}, "schema": []}
{"input": "Clones that expressed DBD exhibited a dominant negative phenotype and did not elicit antiviral activity against vesicular stomatitis virus (VSV) infection upon IFN treatment.", "output": {"entities": {"gene": [{"text": "IFN", "start": 160, "end": 163}]}}, "schema": []}
{"input": "Abp1 preferentially binds to multiple sites in ARS 3002 and to the DNA polymer poly [d (A. T)].", "output": {"entities": {"gene": [{"text": "Abp1", "start": 0, "end": 4}, {"text": "ARS 3002", "start": 47, "end": 55}]}}, "schema": []}
{"input": "Identification, purification, and molecular cloning of autonomously replicating sequence-binding protein 1 from fission yeast Schizosaccharomyces pombe.", "output": {"entities": {"gene": [{"text": "autonomously replicating sequence-binding protein 1 from fission yeast Schizosaccharomyces pombe", "start": 55, "end": 151}]}}, "schema": []}
{"input": "A short open reading frame (ORF2), of unknown function, is present in all FIV isolates.", "output": {"entities": {}}, "schema": []}
{"input": "The patient was homozygous for the underlying mutation, which was found to be a G--> T transversion within the acceptor splice site between intron e and exon 6, abolishing normal RNA splicing.", "output": {"entities": {}}, "schema": []}
{"input": "These regions overlap with the HIT protein similarity regions.", "output": {"entities": {"gene": [{"text": "HIT protein similarity regions", "start": 31, "end": 61}]}}, "schema": []}
{"input": "We tested 10 rats with electrophysiologically guided, ibotenic acid lesions of the PBN (PBNx) to determine whether they could acquire a LiCl-induced CTA to l-alanine (0. 3 M) or demonstrate a sodium appetite following furosemide treatment and overnight access to sodium deficient chow.", "output": {"entities": {}}, "schema": []}
{"input": "Liposomal Amphotericin-B failed in 6/7 patients with culture-proven mycosis who died from infection with Aspergillus (n = 2) and Candida (n = 4), respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Mg2 + and Mn2 + compete for binding sites, with the former having lower affinity.", "output": {"entities": {}}, "schema": []}
{"input": "Magnetic storm indicators could be used in medicine, in geophysics and for special purposes.", "output": {"entities": {}}, "schema": []}
{"input": "Transgenic tobacco plants (ppa-1) constitutively expressing Escherichia coli pyrophosphatase behind the 35S CaMV promoter accumulate high levels of soluble sugars in their leaves [27].", "output": {"entities": {"gene": [{"text": "ppa-1", "start": 27, "end": 32}, {"text": "Escherichia coli pyrophosphatase", "start": 60, "end": 92}, {"text": "35S CaMV promoter", "start": 104, "end": 121}]}}, "schema": []}
{"input": "Hb levels remained adequate (Hb = 10. 68 +/-0. 77 g/dl) after 14. 6 +/-7. 64 months.", "output": {"entities": {"gene": [{"text": "Hb", "start": 0, "end": 2}, {"text": "Hb", "start": 29, "end": 31}]}}, "schema": []}
{"input": "CBT is discussed in comparison with the Wisconsin Card Sorting Test as a potential cognitive activation task for functional neuroimaging of the frontal lobes.", "output": {"entities": {}}, "schema": []}
{"input": "These data indicate that although 218leu retains normal transactivation activity on a p53 promoter in yeast at physiological temperatures, it is not capable of normal p53 function in the presence of a 248trp allele in SNU-C5 cells.", "output": {"entities": {"gene": [{"text": "p53 promoter", "start": 86, "end": 98}, {"text": "p53", "start": 167, "end": 170}, {"text": "248trp allele", "start": 201, "end": 214}]}}, "schema": []}
{"input": "Neither class II nor IV infections precluded transplantation.", "output": {"entities": {}}, "schema": []}
{"input": "Although a great deal is understood about how bHLH factors activate gene transcription via E-box DNA consensus sequences, studies of bHLH factor function in higher eukaryotes often have been hindered by the presence of multiple family members.", "output": {"entities": {"gene": [{"text": "bHLH factors", "start": 46, "end": 58}, {"text": "bHLH factor", "start": 133, "end": 144}]}}, "schema": []}
{"input": "Mobility and supershift assays demonstrated that upstream stimulatory factor (USF) and Sp1 bind to the former elements and competition experiments confirmed that CREB/ATF and AP-1 bind to the CRE/TRE element.", "output": {"entities": {"gene": [{"text": "upstream stimulatory factor", "start": 49, "end": 76}, {"text": "USF", "start": 78, "end": 81}, {"text": "Sp1", "start": 87, "end": 90}, {"text": "CREB", "start": 162, "end": 166}, {"text": "ATF", "start": 167, "end": 170}, {"text": "AP-1", "start": 175, "end": 179}]}}, "schema": []}
{"input": "In these cases, greatly increased human chorionic gonadotropin (hCG) levels and suppressed TSH levels suggest that hCG has thyrotropic activity.", "output": {"entities": {"gene": [{"text": "human chorionic gonadotropin", "start": 34, "end": 62}, {"text": "hCG", "start": 64, "end": 67}, {"text": "TSH", "start": 91, "end": 94}, {"text": "hCG", "start": 115, "end": 118}]}}, "schema": []}
{"input": "High fibrinogen levels could thus be a risk for perioperative thrombosis.", "output": {"entities": {"gene": [{"text": "fibrinogen", "start": 5, "end": 15}]}}, "schema": []}
{"input": "Strontium chloride Sr 89 is costly, but preliminary analysis indicates that it may reduce management expenditures overall. (ABSTRACT TRUNCATED AT 250 WORDS)", "output": {"entities": {}}, "schema": []}
{"input": "We propose that epigenetic features of tissue-specific control and of the control of allelic expression are intricately linked.", "output": {"entities": {}}, "schema": []}
{"input": "This study determined the arthritogenic potential of silicone gel by either mixing it with bovine collagen II (BII) or by injecting silicone gel alone in DA rats.", "output": {"entities": {"gene": [{"text": "bovine collagen II", "start": 91, "end": 109}, {"text": "BII", "start": 111, "end": 114}]}}, "schema": []}
{"input": "This 5' splice site sequence was required for enhanced polyadenylation and was recognized by both U1 small nuclear ribonucleoproteins (snRNPs) and alternative splicing factor/splicing factor 2 (ASF/SF2).", "output": {"entities": {"gene": [{"text": "U1 small nuclear ribonucleoproteins", "start": 98, "end": 133}, {"text": "alternative splicing factor", "start": 147, "end": 174}, {"text": "splicing factor 2", "start": 175, "end": 192}, {"text": "ASF", "start": 194, "end": 197}, {"text": "SF2", "start": 198, "end": 201}]}}, "schema": []}
{"input": "This analysis revealed that SAP 145, together with four other SF3a/SF3b subunits, UV cross-links to pre-mRNA in a 20-nucleotide region upstream of the BPS.", "output": {"entities": {"gene": [{"text": "SAP 145", "start": 28, "end": 35}, {"text": "SF3a", "start": 62, "end": 66}, {"text": "SF3b", "start": 67, "end": 71}]}}, "schema": []}
{"input": "Although the consumption of myoglobin-bound O2 (MbO2) stores in seal muscles has been demonstrated in seal muscles during laboratory simulations of diving, this may not be a feature of normal field diving in which measurements of heart rate and lactate production show marked differences from the profound diving response induced by forced immersion.", "output": {"entities": {"gene": [{"text": "myoglobin", "start": 28, "end": 37}]}}, "schema": []}
{"input": "The human purH cDNA is 1776 base pairs in length encoding for a 591-amino acid polypeptic (Mr = 64, 425).", "output": {"entities": {"gene": [{"text": "human purH cDNA", "start": 4, "end": 19}]}}, "schema": []}
{"input": "The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint.", "output": {"entities": {"gene": [{"text": "gene MPS1", "start": 59, "end": 68}]}}, "schema": []}
{"input": "In our opinion, the SM-CMA system is, despite some shortcomings in its user-interface, a useful and versatile instrument for examination of human semen samples, with desirable features.", "output": {"entities": {}}, "schema": []}
{"input": "Oligonucleotides, designed on the basis of conserved flanking amino acid sequence segments within the catalytic domain of eukaryotic protein kinase C (PKC) proteins, were used as primers for polymerase chain reactions to amplify a 427-bp chromosomal DNA fragment from the filamentous fungus Trichoderma reesei.", "output": {"entities": {"gene": [{"text": "eukaryotic protein kinase C", "start": 122, "end": 149}, {"text": "PKC", "start": 151, "end": 154}]}}, "schema": []}
{"input": "Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis.", "output": {"entities": {"gene": [{"text": "RB", "start": 14, "end": 16}, {"text": "E2F-1", "start": 17, "end": 22}, {"text": "E2F-1", "start": 64, "end": 69}]}}, "schema": []}
{"input": "Apparent loss of differentiation markers characterizes advanced malignant neoplasms.", "output": {"entities": {}}, "schema": []}
{"input": "The method has been satisfactorily applied to the determination of paracetamol in pharmaceutical formulations and biological fluids.", "output": {"entities": {}}, "schema": []}
{"input": "These primers yielded a PCR product of a characteristic length within most Xanthomonas species and pathovars tested.", "output": {"entities": {}}, "schema": []}
{"input": "Rad6 mutants display a remarkably pleiotropic phenotype, implicating the protein in DNA damage-induced mutagenesis, postreplication repair, repression of retrotransposition, and sporulation.", "output": {"entities": {"gene": [{"text": "Rad6 mutants", "start": 0, "end": 12}]}}, "schema": []}
{"input": "RNase protection assays revealed a correlation between the levels of dorsal and ventral skin expression with pigmentation/phaeomelanin phenotypes.", "output": {"entities": {"gene": [{"text": "RNase", "start": 0, "end": 5}]}}, "schema": []}
{"input": "Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases.", "output": {"entities": {"gene": [{"text": "CDKN2D", "start": 77, "end": 83}, {"text": "INK4d", "start": 84, "end": 89}, {"text": "cyclin D-dependent kinases", "start": 107, "end": 133}]}}, "schema": []}
{"input": "Overproduction of HrcA protein from a second copy of hrcA derived from a plasmid (phrcA +) in B. subtilis wild-type and delta hrcA strains prevented heat shock induction of the dnaK and groE operons at the level of transcription almost completely and strongly reduced the amounts of mRNA at a low temperature as well.", "output": {"entities": {"gene": [{"text": "HrcA protein", "start": 18, "end": 30}, {"text": "hrcA", "start": 53, "end": 57}, {"text": "phrcA", "start": 82, "end": 87}, {"text": "hrcA", "start": 126, "end": 130}, {"text": "dnaK", "start": 177, "end": 181}, {"text": "groE operons", "start": 186, "end": 198}]}}, "schema": []}
{"input": "We report the molecular cloning and functional characterization of USF2 isoforms, corresponding to a 44-kDa subunit, USF2a, and a new 38-kDa subunit, USF2b, generated by differential splicing.", "output": {"entities": {"gene": [{"text": "USF2 isoforms", "start": 67, "end": 80}, {"text": "USF2a", "start": 117, "end": 122}, {"text": "USF2b", "start": 150, "end": 155}]}}, "schema": []}
{"input": "The preferential heterodimerization of USF subunits was reproduced ex vivo, while the in vitro association of cotranslated subunits, or recombinant USF proteins, appeared to be random.", "output": {"entities": {"gene": [{"text": "USF subunits", "start": 39, "end": 51}, {"text": "recombinant USF proteins", "start": 136, "end": 160}]}}, "schema": []}
{"input": "Activated PKR may exist as a dimer and phosphorylates the eukaryotic translation initiation factor 2 alpha subunit (cIF-2 alpha) to inhibit polypeptide chain initiation.", "output": {"entities": {"gene": [{"text": "PKR", "start": 10, "end": 13}, {"text": "eukaryotic translation initiation factor 2 alpha subunit", "start": 58, "end": 114}, {"text": "cIF-2 alpha", "start": 116, "end": 127}]}}, "schema": []}
{"input": "GRP78, a molecular chaperone expressed in the endoplasmic reticulum, is a \" glucose-regulated protein \" induced by stress responses that deplete glucose or intracisternal calcium or otherwise disrupt glycoprotein trafficking.", "output": {"entities": {"gene": [{"text": "GRP78", "start": 0, "end": 5}]}}, "schema": []}
{"input": "The IL-8 receptor is a seven-transmembrane spanning receptor coupled to specific heterotrimeric G proteins including Gi and G16.", "output": {"entities": {"gene": [{"text": "IL-8 receptor", "start": 4, "end": 17}, {"text": "heterotrimeric G proteins", "start": 81, "end": 106}, {"text": "Gi", "start": 117, "end": 119}, {"text": "G16", "start": 124, "end": 127}]}}, "schema": []}
{"input": "In a second series of experiments, the efficacy of PDC/HDC Ac was evaluated in both single and multiple dose regiments.", "output": {"entities": {}}, "schema": []}
{"input": "To elucidate the functional significance of Fyn in the expression of viral promoters, we transfected a Fyn-expression vector together with a reporter plasmid containing the chloramphenicol acetyltransferase gene driven by HIV LTR into a human T cell line, Jurkat.", "output": {"entities": {"gene": [{"text": "Fyn", "start": 44, "end": 47}, {"text": "Fyn", "start": 103, "end": 106}, {"text": "chloramphenicol acetyltransferase gene", "start": 173, "end": 211}, {"text": "HIV LTR", "start": 222, "end": 229}]}}, "schema": []}
{"input": "We conducted a prospective, randomized controlled trial of metoprolol, a selective beta-blocker for prevention of gastrointestinal bleeding from portal hypertension in 29 non-selected patients with liver disease and previous gastrointestinal bleeding.", "output": {"entities": {}}, "schema": []}
{"input": "A genetic and molecular analysis of non-inducible qutA mutants showed that all 23 mutations analysed map within the N-terminal half of the encoded QUTA protein.", "output": {"entities": {"gene": [{"text": "qutA mutants", "start": 50, "end": 62}, {"text": "QUTA protein", "start": 147, "end": 159}]}}, "schema": []}
{"input": "These studies indicate that the acidimetric test was less sensitive than the chromogenic cephalosporin substrates and that nitrocefin and S1 could be used to screen for beta-lactamase production in these tested species.", "output": {"entities": {"gene": [{"text": "beta-lactamase", "start": 169, "end": 183}]}}, "schema": []}
{"input": "Suppressors of defective silencing in yeast: effects on transcriptional repression at the HMR locus, cell growth and telomere structure.", "output": {"entities": {"gene": [{"text": "HMR locus", "start": 90, "end": 99}]}}, "schema": []}
{"input": "Although ANP induced systemic capillary filtration, in the calf, filtration was reduced with ANP.", "output": {"entities": {"gene": [{"text": "ANP", "start": 9, "end": 12}, {"text": "ANP", "start": 93, "end": 96}]}}, "schema": []}
{"input": "Recent literature has suggested that beta-2 transferrin can also be used as a clinical marker for perilymph.", "output": {"entities": {"gene": [{"text": "beta-2 transferrin", "start": 37, "end": 55}]}}, "schema": []}
{"input": "With current methodology beta-2 transferrin does not appear to be a reliable clinical marker for perilymph in the operative setting.", "output": {"entities": {"gene": [{"text": "beta-2 transferrin", "start": 25, "end": 43}]}}, "schema": []}
{"input": "The hIGF-I gene has two promoters, P1 and P2.", "output": {"entities": {"gene": [{"text": "hIGF-I gene", "start": 4, "end": 15}]}}, "schema": []}
{"input": "Gel mobility shift assays indicated that at least four nuclear proteins with distinct biochemical and binding properties possess the ability to bind the 3 beta I-A element to produce four DNA-protein complexes (R1 to R4).", "output": {"entities": {}}, "schema": []}
{"input": "Sixty-five patients (aged between 3 years 5 months and 60 years) suffering from medically resistant temporal lobe epilepsy (TLE) were operated on over a period of 33 months in Bethel Epilepsy Center.", "output": {"entities": {}}, "schema": []}
{"input": "Significant correlations existed between FEV1 and the corresponding values of Raw, MEF50 and MEF25, although there were considerable individual differences between test results.", "output": {"entities": {}}, "schema": []}
{"input": "Hybrid female mice (C57BL x CBA) were paired with breeder males (CD-1) and LNG pellets were implanted on day 0, the day on which copulation plugs were found, or on day 2 or day 3 in the postcoital period.", "output": {"entities": {}}, "schema": []}
{"input": "This gene encodes a putative transcription factor with regions of homology to several other proteins including the zinc fingers and other domains of the Drosophila trithorax gene product, and the \" AT-hook \" DNA-binding motif of high mobility group proteins.", "output": {"entities": {"gene": [{"text": "Drosophila trithorax gene product", "start": 153, "end": 186}, {"text": "high mobility group proteins", "start": 229, "end": 257}]}}, "schema": []}
{"input": "Using reference probes as internal standards, we show that the ost transcription unit is located within the cytogenetic band interval 89A1, 2 on the right arm of the third chromosome, and that it exerts diagnostic segmentation gene expression patterns in the embryo.", "output": {"entities": {"gene": [{"text": "ost transcription unit", "start": 63, "end": 85}]}}, "schema": []}
{"input": "The purified recombinant enzyme catalyzed specific phosphoryl transfer from ATP to UMP and CMP.", "output": {"entities": {}}, "schema": []}
{"input": "Studies on the life cycle of Haplorchis pumilio (Looss, 1896) Looss, 1899 with morphological redescription of larval and adult stages.", "output": {"entities": {}}, "schema": []}
{"input": "Regressing microaneurysms in 5 cases of hepatitis B virus related polyarteritis nodosa.", "output": {"entities": {}}, "schema": []}
{"input": "During the following pregnancy ultrasonographic studies of the male fetus in the 16th week of gestation revealed severe micrognathia, short and wide thumbs, and big toes, and bowed tibiae.", "output": {"entities": {}}, "schema": []}
{"input": "Despite an overall survival rate of 43%, survival to discharge varied greatly (0 to 100%) among the 24 diagnostic groups: tumor lysis syndrome and systemic lupus erythematosus (3/3 patients each, 100%), hemolytic uremic syndrome (8/9 patients, 89%).", "output": {"entities": {}}, "schema": []}
{"input": "One hundred units/kg of recombinant human erythropoietin (rhEPO) was given subcutaneously 3 times a week for 3 weeks.", "output": {"entities": {"gene": [{"text": "recombinant human erythropoietin", "start": 24, "end": 56}, {"text": "rhEPO", "start": 58, "end": 63}]}}, "schema": []}
{"input": "A 3-week regimen of erythropoietin may help prevent the donor' s need to receive allogeneic blood transfusion, when the initial Hb levels were below 130 milligrams.", "output": {"entities": {"gene": [{"text": "erythropoietin", "start": 20, "end": 34}, {"text": "Hb", "start": 128, "end": 130}]}}, "schema": []}
{"input": "The mean body mass index (BMI) was 31. 8 +/-6. 3 kg/m2 and 28. 5 +/-6. 3 kg/m2 in women and men, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "These findings demonstrate that haemodialysis patients with chronic hepatitis C respond well to interferon treatment and that a long-term response is achieved in a high proportion of patients.", "output": {"entities": {"gene": [{"text": "interferon", "start": 96, "end": 106}]}}, "schema": []}
{"input": "Synthetic enantiomers of drugs", "output": {"entities": {}}, "schema": []}
{"input": "Polysome analysis further indicated that these germ cell-specific Sp1 mRNAs are translated, albeit with a lower efficiency than the somatic transcript.", "output": {"entities": {"gene": [{"text": "germ cell-specific Sp1 mRNAs", "start": 47, "end": 75}]}}, "schema": []}
{"input": "In nondiabetics the response of tcPO2 but not of LDF was influenced by the values at rest.", "output": {"entities": {}}, "schema": []}
{"input": "This study proposes an estimator for such global synchronizing effects upon unit-pair correlations based on local field potentials (LFPs).", "output": {"entities": {}}, "schema": []}
{"input": "The assembly of sequence ready, high-resolution physical maps and construction of minimally overlapping contigs for the human as well as model genomes requires accurate determination of the extent of overlap between adjacent clones as well as their relative orientation.", "output": {"entities": {}}, "schema": []}
{"input": "The DNA sequences upstream of these termini exhibit homology to plant mitochondrial-processing sites, therefore the proximal 5' ends are most probably generated by RNA processing.", "output": {"entities": {}}, "schema": []}
{"input": "Curing shrinkage and volumetric changes of resin-modified glass ionomer restorative materials.", "output": {"entities": {}}, "schema": []}
{"input": "Here we present genetic evidence suggesting that PP2A functions downstream of Ras1 in the Sevenless receptor tyrosine kinase (RTK) signal transduction pathway that specifies R7 photoreceptor cell fate in the developing Drosophila eye.", "output": {"entities": {"gene": [{"text": "PP2A", "start": 49, "end": 53}, {"text": "Ras1", "start": 78, "end": 82}, {"text": "Sevenless receptor tyrosine kinase", "start": 90, "end": 124}, {"text": "RTK", "start": 126, "end": 129}]}}, "schema": []}
{"input": "QBMDs for a 5% change in response (QBMD05) were 6-fold lower, on average, than the corresponding NOAEL.", "output": {"entities": {}}, "schema": []}
{"input": "The gene encodes an ATP-binding cassette, ABC transporter.", "output": {"entities": {"gene": [{"text": "ATP-binding cassette", "start": 20, "end": 40}, {"text": "ABC transporter", "start": 42, "end": 57}]}}, "schema": []}
{"input": "The T-box motif is present in a family of genes whose structural features and expression patterns support their involvement in developmental gene regulation.", "output": {"entities": {}}, "schema": []}
{"input": "Molecular analysis of a novel schizosaccharomyces pombe gene containing two RNP consensus-sequence RNA-binding domains.", "output": {"entities": {}}, "schema": []}
{"input": "Do overall treatment time, field size, and treatment energy influence local control of T1-T2 squamous cell carcinomas of the glottic larynx? PURPOSE: To evaluate treatment and patient related prognostic factors that may influence local control in the treatment of T1-T2 squamous cell carcinoma of the glottic larynx.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast to the signaling triggered by surface Ig engagement in B lymphocytes, CD38 ligation did not appear to induce tyrosine phosphorylation of the src-like protein tyrosine kinases lyn, fyn, and btk, or of vav-and ras-GTPase-activating protein, nor did it induce detectable changes in cytosolic CA2 + concentrations.", "output": {"entities": {"gene": [{"text": "Ig", "start": 50, "end": 52}, {"text": "CD38", "start": 82, "end": 86}, {"text": "src-like protein tyrosine kinases lyn", "start": 153, "end": 190}, {"text": "fyn", "start": 192, "end": 195}, {"text": "btk", "start": 201, "end": 204}, {"text": "vav-and ras-GTPase-activating protein", "start": 212, "end": 249}]}}, "schema": []}
{"input": "Mutations in the alpha-amanitin conserved domain of the largest subunit of yeast RNA polymerase III affect pausing, RNA cleavage and transcriptional transitions.", "output": {"entities": {"gene": [{"text": "alpha-amanitin", "start": 17, "end": 31}, {"text": "yeast RNA polymerase III", "start": 75, "end": 99}]}}, "schema": []}
{"input": "The evidence presented here suggests that the p40 complex is a ribonucleoprotein complex containing L1Hs RNA (s) and that protein-protein interactions in which alpha-helix structures participate, for example coiled-coils, may occur in the complex.", "output": {"entities": {"gene": [{"text": "p40 complex", "start": 46, "end": 57}, {"text": "L1Hs RNA (s)", "start": 100, "end": 112}]}}, "schema": []}
{"input": "Our data suggest that trans-activation from the prothymosin intron enhancer is a faithful reflection of the transforming properties of the Myc protein.", "output": {"entities": {"gene": [{"text": "prothymosin intron enhancer", "start": 48, "end": 75}, {"text": "Myc protein", "start": 139, "end": 150}]}}, "schema": []}
{"input": "The 5' external transcribed spacer (ETS) region of the pre-rRNA in Saccharomyces cerevisiae contains a sequence with 10 bp of perfect complementarity to the U3 snoRNA.", "output": {"entities": {"gene": [{"text": "U3 snoRNA", "start": 157, "end": 166}]}}, "schema": []}
{"input": "These animals were viable and fertile.", "output": {"entities": {}}, "schema": []}
{"input": "These data suggest that RPF-1 is likely to be involved in early steps in the differentiation of amacrine and ganglion cells.", "output": {"entities": {"gene": [{"text": "RPF-1", "start": 24, "end": 29}]}}, "schema": []}
{"input": "Carboxy-terminal Spc110p truncations lacking the calmodulin binding site can support growth and are also phosphorylated in a cell cycle-specific manner.", "output": {"entities": {"gene": [{"text": "Spc110p", "start": 17, "end": 24}, {"text": "calmodulin", "start": 49, "end": 59}]}}, "schema": []}
{"input": "Both EWS-FLI-1 and FLI-1 proteins function as transcription factors that bind specifically to ets sequences (the ets boxes) present in promoter elements.", "output": {"entities": {"gene": [{"text": "EWS", "start": 5, "end": 8}, {"text": "FLI-1", "start": 9, "end": 14}, {"text": "FLI-1 proteins", "start": 19, "end": 33}, {"text": "ets", "start": 94, "end": 97}, {"text": "ets", "start": 113, "end": 116}]}}, "schema": []}
{"input": "In electromobility shift assays, EWS-FLI-1 binding to the SRE is detectable in the absence of SRF whereas the binding of FLI-1 is not, suggesting that the interaction with DNA is the step which limits ternary complex formation by FLI-1.", "output": {"entities": {"gene": [{"text": "EWS", "start": 33, "end": 36}, {"text": "FLI-1", "start": 37, "end": 42}, {"text": "SRF", "start": 94, "end": 97}, {"text": "FLI-1", "start": 121, "end": 126}, {"text": "FLI-1", "start": 230, "end": 235}]}}, "schema": []}
{"input": "Additional studies with new and reprocessed regenerated cellulose dialyzers comparing 450 and 220 mL/min blood flow rates at 10 minutes showed no change in BTG.", "output": {"entities": {}}, "schema": []}
{"input": "DNA methylation, especially of either one or both of the deoxyadenosines at the two GATC motifs (one in the first exon and the other in the first intron of the rice CatA gene), appeared to be responsible for the CatA promoter activity identified in the transient assay.", "output": {"entities": {"gene": [{"text": "CatA gene", "start": 165, "end": 174}, {"text": "CatA promoter", "start": 212, "end": 225}]}}, "schema": []}
{"input": "The viral LTR was used as the promoter.", "output": {"entities": {"gene": [{"text": "viral LTR", "start": 4, "end": 13}]}}, "schema": []}
{"input": "Overlapping cDNA clones were isolated and sequenced.", "output": {"entities": {}}, "schema": []}
{"input": "Epitope mapping revealed that these three clones appear to recognize an identical epitope domain present on the C-terminal RNP motif of the U1A protein.", "output": {"entities": {"gene": [{"text": "U1A protein", "start": 140, "end": 151}]}}, "schema": []}
{"input": "Variables evaluated were number of weekly anginal events, data from ergometric exercise testing with simultaneous electrocardiographic registration, semiquantitative evaluation of Tc-99m 2-methoxy isobutyl isonitrile (MIBI) scans and rheologic variables.", "output": {"entities": {}}, "schema": []}
{"input": "As the length of the fatty acid decreased, the binding affinity was reduced; myristic acid (14: 0) bound with a K (d) of 1409 +/-423 nM, but medium-chain (decanoic acid, 10: 0) and short-chain (octanoic acid, 8: 0) lipids were not bound at all.", "output": {"entities": {}}, "schema": []}
{"input": "The membrane-distal cytoplasmic region of human granulocyte colony-stimulating factor receptor is required for STAT3 but not STAT1 homodimer formation.", "output": {"entities": {"gene": [{"text": "human granulocyte colony-stimulating factor receptor", "start": 42, "end": 94}, {"text": "STAT3", "start": 111, "end": 116}, {"text": "STAT1 homodimer", "start": 125, "end": 140}]}}, "schema": []}
{"input": "However, whether or not nonsense codon recognition within TPI transcripts takes place prior to or after splicing remained unresolved.", "output": {"entities": {"gene": [{"text": "TPI transcripts", "start": 58, "end": 73}]}}, "schema": []}
{"input": "Although some residues are found reactive toward dimethylsulphate and kethoxal in regions predicted to be unpaired by the phylogenetic secondary structure model of 4. 5S RNA, generally the reactivity is low, and some residues in internal loops are not reactive at all.", "output": {"entities": {"gene": [{"text": "4. 5S RNA", "start": 164, "end": 173}]}}, "schema": []}
{"input": "Ongoing and future investigations may better define the optimal approach for local control, the optimal duration of maintenance chemotherapy, and the possible role of biologic response modifiers and growth factors in further improving the outcome for patients with this disease.", "output": {"entities": {}}, "schema": []}
{"input": "SUMMARY OF REVIEW: We discuss the criteria that make such studies comparable, drawing on the experiences of recent studies performed around the world.", "output": {"entities": {}}, "schema": []}
{"input": "Forty-five patients with pleural lesions identified on CT scans were subsequently examined by MR imaging at 0. 5 T.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: Basal plasma IGF-I levels as well as body mass index (BMI) were lower in amenorrheic patients than in healthy controls.", "output": {"entities": {"gene": [{"text": "plasma IGF-I", "start": 15, "end": 27}]}}, "schema": []}
{"input": "The alpha T3-1 cell line, a GnRH-responsive gonadotroph cell line developed by targeted oncogenesis in transgenic mice, was used to study regulation of the glycoprotein hormone alpha-subunit by activin.", "output": {"entities": {"gene": [{"text": "GnRH", "start": 28, "end": 32}, {"text": "glycoprotein hormone alpha-subunit", "start": 156, "end": 190}, {"text": "activin", "start": 194, "end": 201}]}}, "schema": []}
{"input": "Cotransfection with the ie1 gene resulted in a dramatic increase in the amount of the two enzymes expressed in the transfected cells.", "output": {"entities": {"gene": [{"text": "ie1 gene", "start": 24, "end": 32}]}}, "schema": []}
{"input": "As expected, glycosylation of Env produced from mutants was affected but, irrespective of the glycosylation phenotype, (i) similar quantities of Env were synthesized, (ii) the immunoreactivity of V3 was similar, (iii) gp160 was efficiently cleaved into gp120 and gp41, (vi) Env was exposed at the cell membrane, (v) secreted gp120 bound CD4, and (vi) membrane gp41 was able to induce membrane fusion with CD4 + cells.", "output": {"entities": {"gene": [{"text": "Env", "start": 30, "end": 33}, {"text": "Env", "start": 145, "end": 148}, {"text": "V3", "start": 196, "end": 198}, {"text": "gp160", "start": 218, "end": 223}, {"text": "gp120", "start": 253, "end": 258}, {"text": "gp41", "start": 263, "end": 267}, {"text": "Env", "start": 274, "end": 277}, {"text": "gp120", "start": 325, "end": 330}, {"text": "CD4", "start": 337, "end": 340}, {"text": "gp41", "start": 360, "end": 364}, {"text": "CD4 +", "start": 405, "end": 410}]}}, "schema": []}
{"input": "Effects of posteroventral pallidotomy on Parkinson' s disease.", "output": {"entities": {}}, "schema": []}
{"input": "On the trail of Dr.", "output": {"entities": {}}, "schema": []}
{"input": "However, only complete DnaJ can cooperate with DnaK and a third protein, GrpE, in refolding denatured firefly luciferase.", "output": {"entities": {"gene": [{"text": "complete DnaJ", "start": 14, "end": 27}, {"text": "DnaK", "start": 47, "end": 51}, {"text": "GrpE", "start": 73, "end": 77}, {"text": "denatured firefly luciferase", "start": 92, "end": 120}]}}, "schema": []}
{"input": "The two different phosphoforms of STAT5 have identical in vitro DNA binding specificity and reactivity with tyrosine phosphopeptides, but differ in their cellular localization.", "output": {"entities": {"gene": [{"text": "STAT5", "start": 34, "end": 39}]}}, "schema": []}
{"input": "We have isolated a novel protein from Drosophila nuclear extracts which binds specifically to a site in this second region.", "output": {"entities": {}}, "schema": []}
{"input": "Control of transcription of the erbB-2 gene is an important determinant of receptor expression.", "output": {"entities": {"gene": [{"text": "erbB-2 gene", "start": 32, "end": 43}]}}, "schema": []}
{"input": "DNase I footprinting and electrophoretic mobility shift assays indicate that PBP binds to the half-site of each palindrome with the core recognition sequence TGGGAG.", "output": {"entities": {"gene": [{"text": "DNase I", "start": 0, "end": 7}, {"text": "PBP", "start": 77, "end": 80}]}}, "schema": []}
{"input": "These results demonstrate that sequences in the SH2/SH3/SH2 region of p120 GAP are required for full catalytic activity toward Ras.", "output": {"entities": {"gene": [{"text": "SH2", "start": 48, "end": 51}, {"text": "SH3", "start": 52, "end": 55}, {"text": "SH2", "start": 56, "end": 59}, {"text": "p120 GAP", "start": 70, "end": 78}, {"text": "Ras", "start": 127, "end": 130}]}}, "schema": []}
{"input": "Further analysis of this domain by in vitro mutagenesis pointed to a core of hydrophobic and acidic residues as critical for the activity.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of RAR alpha mutants in transfection studies reveals that the DNA binding domain is sufficient for inhibition of BZLF1 activity.", "output": {"entities": {"gene": [{"text": "RAR alpha mutants", "start": 12, "end": 29}, {"text": "BZLF1", "start": 122, "end": 127}]}}, "schema": []}
{"input": "We measured serum hepatocyte growth factor (HGF) in patients with acute myocardial infarction, angina pectoris, and other heart diseases.", "output": {"entities": {"gene": [{"text": "serum hepatocyte growth factor", "start": 12, "end": 42}, {"text": "HGF", "start": 44, "end": 47}]}}, "schema": []}
{"input": "The neural mechanism of parkinsonian motor symptoms, i. e., rigidity, tremor and akinesia, which are the result of nigrostriatal dopamine deficiency, is interpreted from long-term observations on the effect of surgical and pharmacological treatment of the disease in relation to the neuropathological findings within the substantia nigra zona compacta (SNc).", "output": {"entities": {}}, "schema": []}
{"input": "Protein splicing: evidence for an N-O acyl rearrangement as the initial step in the splicing process.", "output": {"entities": {}}, "schema": []}
{"input": "In agreement with these data, western blot experiments using an antibody directed against the carboxy-terminal portion of the mouse c-kit protein showed that a polypeptide, of the size predicted by the open reading frame of the spermatid-specific c-kit cDNA, accumulates in the latest stages of spermatogenesis and in epididymal spermatozoa.", "output": {"entities": {"gene": [{"text": "c-kit protein", "start": 132, "end": 145}, {"text": "spermatid-specific c-kit cDNA", "start": 228, "end": 257}]}}, "schema": []}
{"input": "It is shown that the (G + C)-rich element of the aldolase C promoter directs transcription in neuronal as well as in nonneuronal cells.", "output": {"entities": {"gene": [{"text": "aldolase C promoter", "start": 49, "end": 68}]}}, "schema": []}
{"input": "Treatment of keratinocytes expressing a normal epidermal growth factor receptor (EGFR) with TGFalpha or epidermal growth factor for 5 min induced PKCdelta tyrosine phosphorylation.", "output": {"entities": {"gene": [{"text": "epidermal growth factor receptor", "start": 47, "end": 79}, {"text": "EGFR", "start": 81, "end": 85}, {"text": "TGFalpha", "start": 92, "end": 100}, {"text": "epidermal growth factor", "start": 104, "end": 127}, {"text": "PKCdelta", "start": 146, "end": 154}]}}, "schema": []}
{"input": "Only one of these bands was supershifted by antibody to p50, whereas antibodies to p65 or other NF-kappaB proteins had no effect.", "output": {"entities": {"gene": [{"text": "p50", "start": 56, "end": 59}, {"text": "p65", "start": 83, "end": 86}, {"text": "NF-kappaB proteins", "start": 96, "end": 114}]}}, "schema": []}
{"input": "We isolated a complementary DNA (cDNA) clone from an RL95-2 expression library that encodes the C1 site-binding protein.", "output": {"entities": {"gene": [{"text": "C1 site-binding protein", "start": 96, "end": 119}]}}, "schema": []}
{"input": "Biol.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, anti-phosphotyrosine antibodies immunoprecipitated 80K-H from cell lysates of FGF-stimulated but not from control fibroblasts.", "output": {"entities": {"gene": [{"text": "anti-phosphotyrosine antibodies", "start": 13, "end": 44}, {"text": "80K-H", "start": 64, "end": 69}, {"text": "FGF", "start": 91, "end": 94}]}}, "schema": []}
{"input": "The novel protein kinases, c-Jun NH2-terminal kinases (JNKs)/stress-activated protein kinases, are also activated by TNF-alpha, IL-1, and CD28 costimulation.", "output": {"entities": {"gene": [{"text": "c-Jun NH2-terminal kinases", "start": 27, "end": 53}, {"text": "JNKs", "start": 55, "end": 59}, {"text": "stress-activated protein kinases", "start": 61, "end": 93}, {"text": "TNF-alpha", "start": 117, "end": 126}, {"text": "IL-1", "start": 128, "end": 132}, {"text": "CD28", "start": 138, "end": 142}]}}, "schema": []}
{"input": "Thus, hGRbeta potentially functions as a dominant negative inhibitor of hGRalpha activity.", "output": {"entities": {"gene": [{"text": "hGRbeta", "start": 6, "end": 13}, {"text": "hGRalpha", "start": 72, "end": 80}]}}, "schema": []}
{"input": "Gas6 contains an NH2-terminal Gla domain followed by four epidermal growth factor-like repeats and tandem globular (G) domains.", "output": {"entities": {"gene": [{"text": "Gas6", "start": 0, "end": 4}, {"text": "epidermal growth factor-like repeats", "start": 58, "end": 94}]}}, "schema": []}
{"input": "Both P5CDh cDNA clones detect a single 3. 2-kb transcript on Northern blots of multiple human tissues, indicating the long cDNA containing the 3'-untranslated intron represents the predominant transcript.", "output": {"entities": {"gene": [{"text": "P5CDh cDNA", "start": 5, "end": 15}]}}, "schema": []}
{"input": "Polymerization of neurofilament L protein in vitro was inhibited by phosphorylation of neurofilament L protein by PKN.", "output": {"entities": {"gene": [{"text": "neurofilament L protein", "start": 18, "end": 41}, {"text": "neurofilament L protein", "start": 87, "end": 110}, {"text": "PKN", "start": 114, "end": 117}]}}, "schema": []}
{"input": "We and others have demonstrated that the c-cbl proto-oncogene product is one of the earliest targets of tyrosine phosphorylation upon T cell receptor stimulation.", "output": {"entities": {"gene": [{"text": "c-cbl proto-oncogene product", "start": 41, "end": 69}, {"text": "T cell receptor", "start": 134, "end": 149}]}}, "schema": []}
{"input": "A substantial fraction of Cbl was constitutively associated with Grb2 and this interaction was mediated by Grb2 SH3 domains.", "output": {"entities": {"gene": [{"text": "Cbl", "start": 26, "end": 29}, {"text": "Grb2", "start": 65, "end": 69}, {"text": "Grb2 SH3", "start": 107, "end": 115}]}}, "schema": []}
{"input": "An AP-1 binding sequence is essential for regulation of the human alpha2 (I) collagen (COL1A2) promoter activity by transforming growth factor-beta.", "output": {"entities": {"gene": [{"text": "AP-1 binding sequence", "start": 3, "end": 24}, {"text": "human alpha2 (I) collagen", "start": 60, "end": 85}, {"text": "COL1A2", "start": 87, "end": 93}, {"text": "transforming growth factor-beta", "start": 116, "end": 147}]}}, "schema": []}
{"input": "Only two patients (0. 3%) had a CA 125 response at the time of clinical progression.", "output": {"entities": {"gene": [{"text": "CA 125", "start": 32, "end": 38}]}}, "schema": []}
{"input": "The men self-selected a prescribed diet at home emphasizing saturated fat as the visible fat for 1 week.", "output": {"entities": {}}, "schema": []}
{"input": "These results illuminate a hitherto unanticipated function of U6 RNA: the modulation of a phosphorylation-dephosphorylation cycle of C1 hnRNP protein that influences the binding affinity of this protein for pre-mRNA.", "output": {"entities": {"gene": [{"text": "U6 RNA", "start": 62, "end": 68}, {"text": "C1 hnRNP protein", "start": 133, "end": 149}]}}, "schema": []}
{"input": "Inclusion of the extended N terminus into the originally reported protein resulted in a striking similarity to the lymphoid factor Lef-1.", "output": {"entities": {"gene": [{"text": "lymphoid factor Lef-1", "start": 115, "end": 136}]}}, "schema": []}
{"input": "Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2.", "output": {"entities": {"gene": [{"text": "mammalian Notch1", "start": 10, "end": 26}, {"text": "CBF1", "start": 37, "end": 41}, {"text": "RBPJk", "start": 42, "end": 47}, {"text": "Epstein-Barr virus EBNA2", "start": 98, "end": 122}]}}, "schema": []}
{"input": "Electrophoretic mobility shift assays (EMSAs) using purified glucocorticoid receptor DNA binding domain (DBD) demonstrated that both GRE-2 and-3 motifs interact with DBD and oligonucleotide competition experiments established that these have different affinities for DBD.", "output": {"entities": {"gene": [{"text": "glucocorticoid receptor DNA binding domain", "start": 61, "end": 103}, {"text": "GRE-2 and-3 motifs", "start": 133, "end": 151}]}}, "schema": []}
{"input": "The large subfamily of receptor tyrosine kinases (RTKs) for which EPH is the prototype have likely roles in intercellular communication during normal mammalian development, but the biochemical signalling pathways utilised by this family are poorly characterised.", "output": {"entities": {"gene": [{"text": "receptor tyrosine kinases", "start": 23, "end": 48}, {"text": "RTKs", "start": 50, "end": 54}, {"text": "EPH", "start": 66, "end": 69}]}}, "schema": []}
{"input": "The 17-kDa protein is required for the systemic infection of plants.", "output": {"entities": {}}, "schema": []}
{"input": "We present here a detailed genomic sequencing analysis of the cytosine methylation patterns of the transposase binding sites within both Ac ends in the wx-m9:: Ac allele, where Ac is inserted into the tenth exon of the Waxy gene.", "output": {"entities": {"gene": [{"text": "transposase", "start": 99, "end": 110}, {"text": "Ac", "start": 137, "end": 139}, {"text": "wx-m9", "start": 152, "end": 157}, {"text": "Ac allele", "start": 160, "end": 169}, {"text": "Ac", "start": 177, "end": 179}, {"text": "Waxy gene", "start": 219, "end": 228}]}}, "schema": []}
{"input": "Krox-20, a zinc finger gene, has a highly conserved pattern of expression in r3 and r5 and is functionally required for their maintenance in mouse embryos.", "output": {"entities": {"gene": [{"text": "Krox-20", "start": 0, "end": 7}, {"text": "zinc finger gene", "start": 11, "end": 27}]}}, "schema": []}
{"input": "Pituitary adenylate cyclase-activating polypeptide regulates prolactin promoter activity via a protein kinase A-mediated pathway that is independent of the transcriptional pathway employed by thyrotropin-releasing hormone.", "output": {"entities": {"gene": [{"text": "adenylate cyclase-activating polypeptide", "start": 10, "end": 50}, {"text": "prolactin promoter", "start": 61, "end": 79}, {"text": "protein kinase A", "start": 95, "end": 111}, {"text": "thyrotropin-releasing hormone", "start": 192, "end": 221}]}}, "schema": []}
{"input": "Clones 33F and 34B encoded identical aromatase proteins of 503 amino acids, but differed in size due to alternative polyadenylation signal usage for the corresponding mRNAs.", "output": {"entities": {"gene": [{"text": "aromatase proteins", "start": 37, "end": 55}]}}, "schema": []}
{"input": "In sorted bone marrow cells expression of both VpreB genes was detected in pro-B/pre-BI and large pre-BII cells, while the RNA steady state levels were at least 100-fold lower in small pre-BII and immature/mature B cells.", "output": {"entities": {"gene": [{"text": "VpreB genes", "start": 47, "end": 58}]}}, "schema": []}
{"input": "We have cloned and sequenced a 3574-bp Bacillus subtilis (Bs) DNA fragment located between the nrdA and citB genes at about 169 degrees on the chromosome.", "output": {"entities": {"gene": [{"text": "nrdA", "start": 95, "end": 99}, {"text": "citB genes", "start": 104, "end": 114}]}}, "schema": []}
{"input": "Aeromonas salmonicida possesses two genes encoding homologs of the major outer membrane protein, OmpA.", "output": {"entities": {"gene": [{"text": "major outer membrane protein", "start": 67, "end": 95}, {"text": "OmpA", "start": 97, "end": 101}]}}, "schema": []}
{"input": "Expression of Msp was toxic to E. coli when the entire msp gene was present.", "output": {"entities": {"gene": [{"text": "Msp", "start": 14, "end": 17}, {"text": "msp gene", "start": 55, "end": 63}]}}, "schema": []}
{"input": "In agreement with previous in vitro data, we have shown that UmuD and UmuD' are able to form both homodimers (UmuD-UmuD and UmuD'-UmuD') and a heterodimer (UmuD-UmuD').", "output": {"entities": {"gene": [{"text": "UmuD", "start": 61, "end": 65}, {"text": "UmuD'", "start": 70, "end": 75}, {"text": "UmuD", "start": 110, "end": 114}, {"text": "UmuD", "start": 115, "end": 119}, {"text": "UmuD'", "start": 124, "end": 129}, {"text": "UmuD'", "start": 130, "end": 135}, {"text": "UmuD", "start": 156, "end": 160}, {"text": "UmuD'", "start": 161, "end": 166}]}}, "schema": []}
{"input": "Lyn kinase immunoprecipitated from lysates of irradiated BCP as well as a full-length glutathione S-transferase (GST)-Lyn fusion protein-phosphorylated recombinant human p34cdc2 on tyrosine 15.", "output": {"entities": {"gene": [{"text": "Lyn kinase", "start": 0, "end": 10}, {"text": "glutathione S-transferase", "start": 86, "end": 111}, {"text": "GST", "start": 113, "end": 116}, {"text": "Lyn", "start": 118, "end": 121}, {"text": "recombinant human p34cdc2", "start": 152, "end": 177}]}}, "schema": []}
{"input": "Binding specificity and modulation of the ApoA-I promoter activity by homo-and heterodimers of nuclear receptors.", "output": {"entities": {"gene": [{"text": "ApoA-I promoter", "start": 42, "end": 57}]}}, "schema": []}
{"input": "There is growing evidence that mammalian AMP-activated protein kinase (AMPK) plays a role in protecting cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways.", "output": {"entities": {"gene": [{"text": "mammalian AMP-activated protein kinase", "start": 31, "end": 69}, {"text": "AMPK", "start": 71, "end": 75}]}}, "schema": []}
{"input": "Sterol-mediated suppression of cleavage of SREBP-1 was found to be dependent on the extreme COOH-terminal region (residue 1034 to the COOH terminus), which exists in two forms as a result of alternative splicing.", "output": {"entities": {"gene": [{"text": "SREBP-1", "start": 43, "end": 50}]}}, "schema": []}
{"input": "Am.", "output": {"entities": {}}, "schema": []}
{"input": "EMSA competition experiments showed that mutations within the direct repeats failed to compete for binding of the nuclear proteins to labeled wild type oligonucleotide.", "output": {"entities": {}}, "schema": []}
{"input": "Transcription from the promoter containing the mutated direct repeats was increased greatly, consistent with the conclusion that these motifs functions in vivo to repress GPT gene expression.", "output": {"entities": {"gene": [{"text": "GPT gene", "start": 171, "end": 179}]}}, "schema": []}
{"input": "However, a > 10-fold increase in ERK3 activity in each PKC beta transfectant was shown by immunoprecipitation with anti-ERK3 monoclonal antibody followed by either immune complex kinase assay or by in gel kinase assay.", "output": {"entities": {"gene": [{"text": "ERK3", "start": 33, "end": 37}, {"text": "PKC beta", "start": 55, "end": 63}, {"text": "anti-ERK3 monoclonal antibody", "start": 115, "end": 144}]}}, "schema": []}
{"input": "Sequence analysis of this 100-bp Col2a1 enhancer revealed several sequence motifs similar to motifs present within the regulatory region of the link protein gene, another cartilage gene.", "output": {"entities": {"gene": [{"text": "Col2a1 enhancer", "start": 33, "end": 48}, {"text": "link protein gene", "start": 144, "end": 161}]}}, "schema": []}
{"input": "Retinoid-dependent activation of the tissue transglutaminase promoter depends on both a proximal regulatory region containing sequences highly conserved between the human and the mouse tissue transglutaminase promoters and a distal region that includes a 30-base pair retinoid response element (mTGRRE1). mTGRRE1 contains three hexanucleotide half-sites (two canonical and one non-canonical) in a DR7/DR5 motif that bind both RAR * RXR heterodimers and RXR homodimers.", "output": {"entities": {"gene": [{"text": "tissue transglutaminase promoter", "start": 37, "end": 69}, {"text": "mouse tissue transglutaminase promoters", "start": 179, "end": 218}, {"text": "DR7", "start": 397, "end": 400}, {"text": "DR5", "start": 401, "end": 404}, {"text": "RAR", "start": 426, "end": 429}, {"text": "RXR", "start": 432, "end": 435}, {"text": "RXR homodimers", "start": 453, "end": 467}]}}, "schema": []}
{"input": "Significantly, pPKR is capable of specifically phosphorylating Ser51 in a synthetic eIF-2alpha peptide, a key characteristic of the eIF-2alpha kinase family.", "output": {"entities": {"gene": [{"text": "pPKR", "start": 15, "end": 19}, {"text": "synthetic eIF-2alpha peptide", "start": 74, "end": 102}, {"text": "eIF-2alpha kinase family", "start": 132, "end": 156}]}}, "schema": []}
{"input": "Vertebrate synapsins constitute a family of synaptic proteins that participate in the regulation of neurotransmitter release.", "output": {"entities": {"gene": [{"text": "Vertebrate synapsins", "start": 0, "end": 20}]}}, "schema": []}
{"input": "Electrophoretic mobility shift assays using crude extracts from FREJ4 cells revealed the binding of a member (s) of the Ets family of transcription factors to the P4 EBS, as well as the interaction of two members of the Sp1 family, Sp1 and Sp3, with the adjacent GC box.", "output": {"entities": {"gene": [{"text": "Ets family of transcription factors", "start": 120, "end": 155}, {"text": "P4 EBS", "start": 163, "end": 169}, {"text": "Sp1 family", "start": 220, "end": 230}, {"text": "Sp1", "start": 232, "end": 235}, {"text": "Sp3", "start": 240, "end": 243}]}}, "schema": []}
{"input": "ZEBRA and cellular AP-1 bZip activators, such as c-Fos, have homologous DNA-binding domains, and their DNA-binding specificities overlap.", "output": {"entities": {"gene": [{"text": "ZEBRA", "start": 0, "end": 5}, {"text": "AP-1 bZip activators", "start": 19, "end": 39}, {"text": "c-Fos", "start": 49, "end": 54}]}}, "schema": []}
{"input": "This result suggested that mutant I299 has diminished cap-binding activity.", "output": {"entities": {}}, "schema": []}
{"input": "UV cross-linking experiments demonstrated that HSV infection caused enhanced binding of protein factors, including the 64-kDa component of cleavage stimulation factor (CstF), to poly (A) site RNAs from virus genes of all temporal classes and that this enhanced binding required expression of IE63.", "output": {"entities": {"gene": [{"text": "64-kDa component of cleavage stimulation factor", "start": 119, "end": 166}, {"text": "CstF", "start": 168, "end": 172}, {"text": "IE63", "start": 292, "end": 296}]}}, "schema": []}
{"input": "CM-ACO3 is expressed in flowers and is not induced by any of the stimuli tested.", "output": {"entities": {"gene": [{"text": "CM-ACO3", "start": 0, "end": 7}]}}, "schema": []}
{"input": "We show here that these Jun/eb1 chimeras are potent transactivators of AP1 sites and that they can cooperate with c-Ha-Ras to induce foci.", "output": {"entities": {"gene": [{"text": "Jun", "start": 24, "end": 27}, {"text": "eb1", "start": 28, "end": 31}, {"text": "AP1 sites", "start": 71, "end": 80}, {"text": "c-Ha-Ras", "start": 114, "end": 122}]}}, "schema": []}
{"input": "In synchronized HeLa cells, expression of luciferase activity was induced at the beginning of DNA synthesis and was dependent on the presence of an E2F-binding site in the H2A. 1 promoter.", "output": {"entities": {"gene": [{"text": "luciferase", "start": 42, "end": 52}, {"text": "E2F-binding site", "start": 148, "end": 164}, {"text": "H2A. 1 promoter", "start": 172, "end": 187}]}}, "schema": []}
{"input": "Utilizing transient transfection studies in HepG2 cells, we have shown that deletion of the factor VIII promoter sequences distal to nucleotide-44 results in a significant but small increase in promoter activity.", "output": {"entities": {"gene": [{"text": "factor VIII promoter sequences", "start": 92, "end": 122}]}}, "schema": []}
{"input": "We constructed a yeast reporter strain containing the lacZ gene under the control of the CYC1 promoter associated with three copies of TRE-1.", "output": {"entities": {"gene": [{"text": "lacZ gene", "start": 54, "end": 63}, {"text": "CYC1 promoter", "start": 89, "end": 102}, {"text": "TRE-1", "start": 135, "end": 140}]}}, "schema": []}
{"input": "If hnRNP K is a transcription factor, then interactions with the RNA polymerase II transcription apparatus are predicted.", "output": {"entities": {"gene": [{"text": "hnRNP K", "start": 3, "end": 10}, {"text": "RNA polymerase II", "start": 65, "end": 82}]}}, "schema": []}
{"input": "A developmentally regulated 4. 6 kb mRNA is recognized on Northern blots of oocyte RNA using the X. laevis cDNA.", "output": {"entities": {}}, "schema": []}
{"input": "Sequence conservation is greatest for residues located near the active centers of the exo and pol domains of the E. coli DNA polymerase I structure.", "output": {"entities": {"gene": [{"text": "exo", "start": 86, "end": 89}, {"text": "pol domains", "start": 94, "end": 105}, {"text": "E. coli DNA polymerase I", "start": 113, "end": 137}]}}, "schema": []}
{"input": "Despite the favourable natural history of acute BI, mild, moderate, and severe posttraumatic changes were shown to appear as cicatricial-adhesive and atrophic processes, intracerebral cysts, porencephaly, which result in posttraumatic epilepsy, hydrocephalus, etc.", "output": {"entities": {}}, "schema": []}
{"input": "Several cytokines exhibit a high degree of temporal regulation as well as somnogenic potency (e. g., interleukin-1 [IL-1], tumor necrosis factor-alpha [TNF-alpha]).", "output": {"entities": {"gene": [{"text": "interleukin-1", "start": 101, "end": 114}, {"text": "IL-1", "start": 116, "end": 120}, {"text": "tumor necrosis factor-alpha", "start": 123, "end": 150}, {"text": "TNF-alpha", "start": 152, "end": 161}]}}, "schema": []}
{"input": "As pH and Hb can also affect mixed venous CO2 content, the effect on Q was also assessed.", "output": {"entities": {"gene": [{"text": "Hb", "start": 10, "end": 12}]}}, "schema": []}
{"input": "No difference in elastin peptide concentration was observed between emphysematous patients and control subjects (mean +/-SD = 2. 39 +/-1. 18 micrograms/ml in patients versus 2. 55 +/-1. 34 micrograms/ml in policemen and 2. 59 +/-1. 20 micrograms/ml in coal miners).", "output": {"entities": {"gene": [{"text": "elastin peptide", "start": 17, "end": 32}]}}, "schema": []}
{"input": "Identification of this region as the E. coli tmk gene was confirmed by functional complementation of a yeast dTMP kinase temperature-sensitive mutant and by in vitro enzyme assay of the thymidylate kinase activity in cell extracts of E. coli by use of tmk-overproducing plasmids.", "output": {"entities": {"gene": [{"text": "E. coli tmk gene", "start": 37, "end": 53}, {"text": "yeast dTMP kinase", "start": 103, "end": 120}, {"text": "thymidylate kinase", "start": 186, "end": 204}, {"text": "tmk", "start": 252, "end": 255}]}}, "schema": []}
{"input": "The structural gene for copper-and topa quinone-containing monoamine oxidase (maoA) and an unknown amine oxidase gene have been located at 30. 9 min on the Escherichia coli chromosome.", "output": {"entities": {"gene": [{"text": "copper-and topa quinone-containing monoamine oxidase", "start": 24, "end": 76}, {"text": "maoA", "start": 78, "end": 82}, {"text": "amine oxidase gene", "start": 99, "end": 117}]}}, "schema": []}
{"input": "This interaction is mediated by the SH2 domain of Crk and can be inhibited with a phosphopeptide containing the Crk-SH2 binding motif.", "output": {"entities": {"gene": [{"text": "SH2 domain", "start": 36, "end": 46}, {"text": "Crk", "start": 50, "end": 53}, {"text": "Crk", "start": 112, "end": 115}, {"text": "SH2", "start": 116, "end": 119}]}}, "schema": []}
{"input": "The cDNA corresponding to the FPS1 gene was isolated by functional complementation of a mutant yeast strain defective in FPS activity (Delourme, D., Lacroute, F., and Karst, F.", "output": {"entities": {"gene": [{"text": "FPS1 gene", "start": 30, "end": 39}, {"text": "FPS", "start": 121, "end": 124}]}}, "schema": []}
{"input": "The isolated plasmin fragments of VEGF were compared with respect to heparin binding, interaction with soluble VEGF receptors, and ability to promote endothelial cell mitogenesis.", "output": {"entities": {"gene": [{"text": "plasmin", "start": 13, "end": 20}, {"text": "VEGF", "start": 34, "end": 38}, {"text": "VEGF receptors", "start": 111, "end": 125}]}}, "schema": []}
{"input": "The members of the Myb family of transcription factors are defined by homology in the DNA-binding domain; all bind the Myb-binding site (MBS) sequence (YG (A/G) C (A/C/G) GTT (G/A)).", "output": {"entities": {"gene": [{"text": "Myb family of transcription factors", "start": 19, "end": 54}, {"text": "Myb-binding site", "start": 119, "end": 135}, {"text": "MBS", "start": 137, "end": 140}]}}, "schema": []}
{"input": "In contrast, when the isoform containing the C epsilon4 domain joined directly to the M2 exon (IgE grande) is expressed in the J558L cell line, it is degraded intracellularly, suggesting a cell line-dependent regulation of secretion.", "output": {"entities": {"gene": [{"text": "IgE grande", "start": 95, "end": 105}]}}, "schema": []}
{"input": "Human cytomegalovirus immediate-early protein IE2 tethers a transcriptional repression domain to p53.", "output": {"entities": {"gene": [{"text": "Human cytomegalovirus immediate-early protein IE2", "start": 0, "end": 49}, {"text": "p53", "start": 97, "end": 100}]}}, "schema": []}
{"input": "The specificity of action of C/EBP family members may be derived from the characteristics of each factor, including the expression profiles, the DNA binding affinities, the cofactors, and so on, in addition to the DNA binding specificities.", "output": {"entities": {"gene": [{"text": "C/EBP family members", "start": 29, "end": 49}]}}, "schema": []}
{"input": "The antibodies inhibited specifically the transcription of DNA polymerase alpha promoter in vitro.", "output": {"entities": {"gene": [{"text": "DNA polymerase alpha", "start": 59, "end": 79}]}}, "schema": []}
{"input": "Immunocytochemical analysis demonstrated the presence of DREF polypeptide in nuclei after the eighth nuclear division cycle, suggesting that nuclear accumulation of DREF is important for the coordinate zygotic expression of DNA replication-related genes carrying DRE sequences.", "output": {"entities": {"gene": [{"text": "DREF polypeptide", "start": 57, "end": 73}, {"text": "DREF", "start": 165, "end": 169}]}}, "schema": []}
{"input": "A DNA fragment carrying 1, 100 nucleotides derived from the 5'-flanking region of the UGT1A1 gene was enough for MC induction.", "output": {"entities": {"gene": [{"text": "UGT1A1 gene", "start": 86, "end": 97}]}}, "schema": []}
{"input": "This result supports the argument that the beta' subunit plays an essential role in determining the progress of transcription elongation.", "output": {"entities": {}}, "schema": []}
{"input": "Two XPG regions with putative NLS [amino acid (AA) coordinates: NLS-B (AA 1057-1074) and NLS-C (AA 1171-1185)] were each shown to independently localize the beta-gal extensively (> 80%) to the nucleus of HeLa cells.", "output": {"entities": {"gene": [{"text": "XPG regions", "start": 4, "end": 15}, {"text": "beta-gal", "start": 157, "end": 165}]}}, "schema": []}
{"input": "The lacS gene was cloned in an E. coli-Streptococcus shuttle vector and was expressed both in a lacS deletion derivative of S. thermophilus and in a pNZ63-cured strain, L. lactis NZ6091.", "output": {"entities": {"gene": [{"text": "lacS gene", "start": 4, "end": 13}, {"text": "lacS", "start": 96, "end": 100}]}}, "schema": []}
{"input": "The genome of all retroviruses consists of two identical RNAs noncovalently linked near their 5' end.", "output": {"entities": {}}, "schema": []}
{"input": "The extraction recovery of Amphotericin B from the cerebrospinal fluid is higher than 90% over the entire linear range.", "output": {"entities": {}}, "schema": []}
{"input": "HuEpo-R Ab inhibited Epo-induced parental UT-7 cell growth, but not that of cells of clone 12, suggesting that the muEpo-R is able to induce human UT-7 cell proliferation.", "output": {"entities": {"gene": [{"text": "HuEpo-R Ab", "start": 0, "end": 10}, {"text": "Epo", "start": 21, "end": 24}, {"text": "muEpo-R", "start": 115, "end": 122}]}}, "schema": []}
{"input": "The frequency of integrations that led to transcription of the lacZ gene was estimated to be 0. 5% of all integrations, of which 14% were downregulated on differentiation of 32D cells towards neutrophils.", "output": {"entities": {"gene": [{"text": "lacZ gene", "start": 63, "end": 72}]}}, "schema": []}
{"input": "Interaction of the Fur repressor with a 150-bp fragment encompassing the pvdS promoter was demonstrated in vivo by the Fur titration assay and confirmed in vitro by gel retardation experiments with a partially purified Fur preparation.", "output": {"entities": {"gene": [{"text": "Fur repressor", "start": 19, "end": 32}, {"text": "pvdS promoter", "start": 73, "end": 86}, {"text": "Fur", "start": 119, "end": 122}, {"text": "Fur", "start": 219, "end": 222}]}}, "schema": []}
{"input": "This protein encoded by this cDNA, which we have termed p150TSP (for TPR-containing, SH2-binding phosphoprotein), is located predominantly in the nucleus and is highly conserved in evolution.", "output": {"entities": {"gene": [{"text": "p150TSP", "start": 56, "end": 63}, {"text": "SH2-binding phosphoprotein", "start": 85, "end": 111}]}}, "schema": []}
{"input": "Both mutant receptors were expressed on the cell surface and bound insulin normally, but showed markedly impaired autophosphorylation in response to insulin.", "output": {"entities": {"gene": [{"text": "insulin", "start": 67, "end": 74}, {"text": "insulin", "start": 149, "end": 156}]}}, "schema": []}
{"input": "EMBO J.", "output": {"entities": {}}, "schema": []}
{"input": "Taken together, our results indicate that thrombin-stimulated vascular smooth muscle proliferation is delayed and requires the de novo expression of one or more autocrine mitogens.", "output": {"entities": {"gene": [{"text": "thrombin", "start": 42, "end": 50}]}}, "schema": []}
{"input": "Transcription from adenovirus E2-early promoter is controlled by a unique array of four cis-acting elements which include an atypical TBP site, two E2F sites present in an inverted orientation relative to each other, and an ATF site.", "output": {"entities": {"gene": [{"text": "adenovirus E2-early promoter", "start": 19, "end": 47}, {"text": "TBP site", "start": 134, "end": 142}, {"text": "E2F sites", "start": 148, "end": 157}, {"text": "ATF site", "start": 224, "end": 232}]}}, "schema": []}
{"input": "Furthermore, we showed that the IL-6/interferon gamma (IFN gamma) response element in the IRF-1 promoter (IR/IRF-1), which contains a Stat-binding site and an adjacent CRE-like site, also makes IL-6-induced binding complexes similar to JRE-IL6-BCs.", "output": {"entities": {"gene": [{"text": "IL-6", "start": 32, "end": 36}, {"text": "interferon gamma", "start": 37, "end": 53}, {"text": "IFN gamma", "start": 55, "end": 64}, {"text": "IRF-1 promoter", "start": 90, "end": 104}, {"text": "IR", "start": 106, "end": 108}, {"text": "IRF-1", "start": 109, "end": 114}, {"text": "Stat-binding site", "start": 134, "end": 151}, {"text": "IL-6", "start": 194, "end": 198}, {"text": "IL6", "start": 240, "end": 243}]}}, "schema": []}
{"input": "A second peptide (amino acids 58-77) also antagonized p21-activity, but this peptide did not affect the ability of p21 to interact with cyclin E/Cdk2.", "output": {"entities": {"gene": [{"text": "p21", "start": 54, "end": 57}, {"text": "p21", "start": 115, "end": 118}, {"text": "cyclin E", "start": 136, "end": 144}, {"text": "Cdk2", "start": 145, "end": 149}]}}, "schema": []}
{"input": "A p21 peptide spanning amino acids 139-164 was found to bind PCNA in a filter binding assay and this peptide suppressed recombinant p21-PCNA interaction.", "output": {"entities": {"gene": [{"text": "p21 peptide", "start": 2, "end": 13}, {"text": "PCNA", "start": 61, "end": 65}, {"text": "p21", "start": 132, "end": 135}, {"text": "PCNA", "start": 136, "end": 140}]}}, "schema": []}
{"input": "Results were supported by the agar diffusion method for Y. enterocolitica, whereas inhibition activity was not found for A. hydrophila.", "output": {"entities": {}}, "schema": []}
{"input": "OND 8 mg tid days 2-3, and 8 mg tid prn days 4-5 and prednisolone 75-100 mg qds days 2-5 and 2) MCP 30 mg/metylprednisolone 80 mg i. v. before CT and MCP 20 mg p. r. after 4 and 8 h respectively.", "output": {"entities": {}}, "schema": []}
{"input": "The dynamic properties of this protein fragment were measured and analyzed using both isotropic and anisotropic models of molecular motion.", "output": {"entities": {}}, "schema": []}
{"input": "Adduction of the human N-ras codon 61 sequence with (-)-(7S, 8R, 9R, 10S)-7, 8-dihydroxy-9, 10-epoxy-7, 8, 9, 10-tetrahydrobenzo [a] pyrene: structural refinement of the intercalated SRSR (61, 2) (-)-(7S, 8R, 9S, 10R)-N6-[10-(7, 8, 9, 10-tetrahydrobenzo [a] pyrenyl)]-2'-deoxyadenosyl adduct from 1H NMR.", "output": {"entities": {"gene": [{"text": "human N-ras codon 61 sequence", "start": 17, "end": 46}]}}, "schema": []}
{"input": "This fragment can bind several trans-acting factors in vitro, including GATA-1 and members of the Ets family.", "output": {"entities": {"gene": [{"text": "GATA-1", "start": 72, "end": 78}, {"text": "Ets family", "start": 98, "end": 108}]}}, "schema": []}
{"input": "These different observations exclude a heterozygosity of the A--> G mutation at codon beta 77, as well as a deletion comparable to that of Hbs Lepore or Kenya, or a beta-globin gene duplication, and point to a nontraditional inheritance of Hb Costa Rica.", "output": {"entities": {"gene": [{"text": "Hbs Lepore or Kenya", "start": 139, "end": 158}, {"text": "beta-globin gene", "start": 165, "end": 181}, {"text": "Hb Costa Rica", "start": 240, "end": 253}]}}, "schema": []}
{"input": "This is the first description, to our knowledge, of regulatory elements that control expression of a gene encoding a B7 costimulatory molecule.", "output": {"entities": {"gene": [{"text": "B7 costimulatory molecule", "start": 117, "end": 142}]}}, "schema": []}
{"input": "DNA-STAT complexes were detected in all Bcr/Abl-transformed cell lines and they were supershifted by antibodies against STAT1 and STAT5.", "output": {"entities": {"gene": [{"text": "DNA-STAT complexes", "start": 0, "end": 18}, {"text": "Bcr", "start": 40, "end": 43}, {"text": "Abl", "start": 44, "end": 47}, {"text": "STAT1", "start": 120, "end": 125}, {"text": "STAT5", "start": 130, "end": 135}]}}, "schema": []}
{"input": "When overexpressed in an appropriate cell line, TAN-1C prevented kappa B-dependent transactivation in transient reporter gene assays in a fashion similar to the structurally related protein, Bcl-3.", "output": {"entities": {"gene": [{"text": "TAN-1C", "start": 48, "end": 54}, {"text": "kappa B", "start": 65, "end": 72}, {"text": "Bcl-3", "start": 191, "end": 196}]}}, "schema": []}
{"input": "T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells.", "output": {"entities": {"gene": [{"text": "Notch", "start": 33, "end": 38}, {"text": "Notch", "start": 64, "end": 69}, {"text": "I kappa B", "start": 84, "end": 93}, {"text": "nuclear factor-kappa B", "start": 138, "end": 160}]}}, "schema": []}
{"input": "Polyprotein processing in Southampton virus: identification of 3C-like protease cleavage sites by in vitro mutagenesis.", "output": {"entities": {"gene": [{"text": "3C-like protease", "start": 63, "end": 79}]}}, "schema": []}
{"input": "The humanized LL2 (hLL2), lacking light chain variable region glycosylation, exhibited immunoreactivities that were comparable to that of chimeric LL2 (cLL2), which was shown previously to have antigen-binding properties similar to its murine counterpart, suggesting that the VK-appended oligosaccharides found in mLL2 are not necessary for antigen binding.", "output": {"entities": {"gene": [{"text": "humanized LL2", "start": 4, "end": 17}, {"text": "hLL2", "start": 19, "end": 23}, {"text": "light chain variable region", "start": 34, "end": 61}, {"text": "chimeric LL2", "start": 138, "end": 150}, {"text": "cLL2", "start": 152, "end": 156}, {"text": "mLL2", "start": 314, "end": 318}]}}, "schema": []}
{"input": "An apparent N-terminal transit peptide in the coding region and a 3' poly (A) tail exist in the cDNA clone indicated that this chloroplast protein as nuclear encoded.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, a critical question is how HOX proteins select the correct sets of target genes in vivo.", "output": {"entities": {"gene": [{"text": "HOX proteins", "start": 33, "end": 45}]}}, "schema": []}
{"input": "RAS2val19, a dominant activated form of Saccharomyces cerevisiae Ras2, stimulates both filamentous growth and expression of a transcriptional reporter FG (TyA):: lacZ but does not induce the mating pathway reporter FUS1:: lacZ.", "output": {"entities": {"gene": [{"text": "RAS2val19", "start": 0, "end": 9}, {"text": "Saccharomyces cerevisiae Ras2", "start": 40, "end": 69}, {"text": "FG", "start": 151, "end": 153}, {"text": "TyA", "start": 155, "end": 158}, {"text": "lacZ", "start": 162, "end": 166}, {"text": "mating pathway reporter FUS1", "start": 191, "end": 219}, {"text": "lacZ", "start": 222, "end": 226}]}}, "schema": []}
{"input": "Moreover, the Rho family protein Cdc42, a conserved morphogenetic G protein, is also a potent regulator of filamentous growth and FG (TyA):: lacZ expression in S. cerevisiae.", "output": {"entities": {"gene": [{"text": "Rho family protein Cdc42", "start": 14, "end": 38}, {"text": "morphogenetic G protein", "start": 52, "end": 75}, {"text": "FG", "start": 130, "end": 132}, {"text": "TyA", "start": 134, "end": 137}, {"text": "lacZ", "start": 141, "end": 145}]}}, "schema": []}
{"input": "Each immunoprecipitate contained a complex of N1 (deltaEC) and CBF1.", "output": {"entities": {"gene": [{"text": "N1 (deltaEC)", "start": 46, "end": 58}, {"text": "CBF1", "start": 63, "end": 67}]}}, "schema": []}
{"input": "This region includes verA, a structural gene previously shown to be required for ST biosynthesis, and 24 additional closely spaced transcripts ranging in size from 0. 6 to 7. 2 kb that are coordinately induced only under ST-producing conditions.", "output": {"entities": {"gene": [{"text": "verA", "start": 21, "end": 25}]}}, "schema": []}
{"input": "Subcellular localizations of the wild-type CBFbeta and the CBFbeta-SMMHC fusion protein were determined by immunofluorescence of NIH 3T3 cells that overexpress wild-type or fusion protein.", "output": {"entities": {"gene": [{"text": "wild-type CBFbeta", "start": 33, "end": 50}, {"text": "CBFbeta", "start": 59, "end": 66}, {"text": "SMMHC", "start": 67, "end": 72}]}}, "schema": []}
{"input": "Menstrual-cycle phase did not significantly affect personality variables in either group.", "output": {"entities": {}}, "schema": []}
{"input": "We report the isolation of human cDNAs homologous to the Drosophila dishevelled (dsh) segment-polarity gene.", "output": {"entities": {"gene": [{"text": "Drosophila dishevelled", "start": 57, "end": 79}, {"text": "dsh", "start": 81, "end": 84}]}}, "schema": []}
{"input": "Ca2 + decreased Zn2 + binding in S100 beta but it did not influence binding to MRP14, suggesting that the Zn2 + binding site was distinct from and independent of the two Ca2 + binding domains.", "output": {"entities": {"gene": [{"text": "S100 beta", "start": 33, "end": 42}, {"text": "MRP14", "start": 79, "end": 84}]}}, "schema": []}
{"input": "Two overlapping clones contained the complete Adh-2 gene composed of nine exons in a 12-kb region, with the placement of introns matching that observed in other mammalian ADH genes.", "output": {"entities": {"gene": [{"text": "Adh-2 gene", "start": 46, "end": 56}, {"text": "mammalian ADH genes", "start": 161, "end": 180}]}}, "schema": []}
{"input": "Ligation of CD40 rescues Ramos-Burkitt lymphoma B cells from calcium ionophore-and antigen receptor-triggered apoptosis by inhibiting activation of the cysteine protease CPP32/Yama and cleavage of its substrate PARP.", "output": {"entities": {"gene": [{"text": "CD40", "start": 12, "end": 16}, {"text": "cysteine protease CPP32", "start": 152, "end": 175}, {"text": "Yama", "start": 176, "end": 180}, {"text": "PARP", "start": 211, "end": 215}]}}, "schema": []}
{"input": "Large T antigen was coimmunoprecipitated by antibodies to epitope-tagged TBP, endogenous TBP, hTAF (II) 100, hTAF (II) 130, and hTAF (II) 250, under conditions where holo-TFIID would be precipitated.", "output": {"entities": {"gene": [{"text": "Large T antigen", "start": 0, "end": 15}, {"text": "TBP", "start": 73, "end": 76}, {"text": "TBP", "start": 89, "end": 92}, {"text": "hTAF (II) 100", "start": 94, "end": 107}, {"text": "hTAF (II) 130", "start": 109, "end": 122}, {"text": "hTAF (II) 250", "start": 128, "end": 141}, {"text": "holo-TFIID", "start": 166, "end": 176}]}}, "schema": []}
{"input": "Northern blot hybridization demonstrated that HEP-COP was expressed in a wide range of human adult and fetal tissues.", "output": {"entities": {"gene": [{"text": "HEP", "start": 46, "end": 49}, {"text": "COP", "start": 50, "end": 53}]}}, "schema": []}
{"input": "A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene.", "output": {"entities": {"gene": [{"text": "sterol regulatory element binding protein", "start": 18, "end": 59}, {"text": "3-hydroxy-3-methylglutaryl coenzyme A reductase gene", "start": 77, "end": 129}]}}, "schema": []}
{"input": "E3/19K resides in the endoplasmic reticulum where it binds to MHC class I molecules, thereby preventing their transport to the cell surface.", "output": {"entities": {"gene": [{"text": "E3/19K", "start": 0, "end": 6}, {"text": "MHC class I molecules", "start": 62, "end": 83}]}}, "schema": []}
{"input": "When the PHT and CSA groups were compared, Hyp levels were significantly higher in the PHT-GO + group than in the CSA-GO + group.", "output": {"entities": {}}, "schema": []}
{"input": "Among the LE6 deletions, only one had a reduced transformation efficiency, while seven transformed cells at least as efficiently as wild-type LE6.", "output": {"entities": {"gene": [{"text": "LE6", "start": 10, "end": 13}, {"text": "wild-type LE6", "start": 132, "end": 145}]}}, "schema": []}
{"input": "ORF E8 colinear with ORF E6, which could generate a 50-amino-acid protein with a hydrophobic segment, did not transform cells when cloned into the pZipNeo vector.", "output": {"entities": {"gene": [{"text": "ORF E8", "start": 0, "end": 6}, {"text": "ORF E6", "start": 21, "end": 27}]}}, "schema": []}
{"input": "Clb2/Cdc28 kinase is not required for the repression of MCB-binding factor transcriptional activity in G2 and M phase.", "output": {"entities": {"gene": [{"text": "Clb2", "start": 0, "end": 4}, {"text": "Cdc28", "start": 5, "end": 10}, {"text": "MCB-binding factor", "start": 56, "end": 74}]}}, "schema": []}
{"input": "The carboxy terminus of Mbp1 is sufficient for interaction with Swi6, and the carboxy terminus of Swi6 is required for interaction with Mbp1.", "output": {"entities": {"gene": [{"text": "Mbp1", "start": 24, "end": 28}, {"text": "Swi6", "start": 64, "end": 68}, {"text": "Swi6", "start": 98, "end": 102}, {"text": "Mbp1", "start": 136, "end": 140}]}}, "schema": []}
{"input": "Multiple single-stranded cis elements are associated with activated chromatin of the human c-myc gene in vivo.", "output": {"entities": {"gene": [{"text": "human c-myc gene", "start": 85, "end": 101}]}}, "schema": []}
{"input": "A new UASH consensus sequence derived from this mutational analysis closely matches a consensus Abf1 binding site.", "output": {"entities": {"gene": [{"text": "Abf1 binding site", "start": 96, "end": 113}]}}, "schema": []}
{"input": "We have isolated and analyzed human CTCF cDNA clones and show here that the ubiquitously expressed 11-zinc-finger factor CTCF is an exceptionally highly conserved protein displaying 93% identity between avian and human amino acid sequences.", "output": {"entities": {"gene": [{"text": "human CTCF cDNA", "start": 30, "end": 45}, {"text": "11-zinc-finger factor CTCF", "start": 99, "end": 125}]}}, "schema": []}
{"input": "Mutational analysis of the P2-proximal CTCF binding site and transient-cotransfection experiments demonstrate that CTCF is a transcriptional repressor of the human c-myc gene.", "output": {"entities": {"gene": [{"text": "P2-proximal CTCF binding site", "start": 27, "end": 56}, {"text": "CTCF", "start": 115, "end": 119}, {"text": "human c-myc gene", "start": 158, "end": 174}]}}, "schema": []}
{"input": "A chromosome transmission fidelity (ctf) mutant, s138, of Saccharomyces cerevisiae was identified by its centromere (CEN) transcriptional readthrough phenotype, suggesting perturbed kinetochore integrity in vivo.", "output": {"entities": {"gene": [{"text": "chromosome transmission fidelity", "start": 2, "end": 34}, {"text": "ctf", "start": 36, "end": 39}]}}, "schema": []}
{"input": "The growth defect of a reg1 reg2 double mutant is alleviated by a loss-of-function mutation in the SNF1-encoded protein kinase.", "output": {"entities": {"gene": [{"text": "reg1 reg2 double mutant", "start": 23, "end": 46}, {"text": "SNF1-encoded protein kinase", "start": 99, "end": 126}]}}, "schema": []}
{"input": "Expression of the phenylalanine hydroxylase gene in livers and kidneys of rodents is activated at birth and is induced by glucocorticoids and cyclic AMP in the liver.", "output": {"entities": {"gene": [{"text": "phenylalanine hydroxylase gene", "start": 18, "end": 48}]}}, "schema": []}
{"input": "We report here the identification of a cDNA that encodes a new member of the GTPase-activating protein (GAP) family of GTPase regulators.", "output": {"entities": {"gene": [{"text": "GTPase-activating protein", "start": 77, "end": 102}, {"text": "GAP", "start": 104, "end": 107}, {"text": "GTPase", "start": 119, "end": 125}]}}, "schema": []}
{"input": "In this study, we further investigated the regulation of the synthesis of the c-mos oncogene product, which is necessary for the activation of Cdc2.", "output": {"entities": {"gene": [{"text": "c-mos oncogene product", "start": 78, "end": 100}, {"text": "Cdc2", "start": 143, "end": 147}]}}, "schema": []}
{"input": "The heterogeneity of bovine IgG2--VIII.", "output": {"entities": {"gene": [{"text": "bovine IgG2--VIII", "start": 21, "end": 38}]}}, "schema": []}
{"input": "The ability of BCL-6 to function as a transcriptional repressor may contribute to its ability to transform B lymphocytes in diffuse large cell lymphoma.", "output": {"entities": {"gene": [{"text": "BCL-6", "start": 15, "end": 20}]}}, "schema": []}
{"input": "Positioning this uORF, together with its accompanying Kozak sequences, between a heterologous promoter from SV40 and a CAT reporter gene resulted in marked inhibition of CAT protein production without a decrease in CAT mRNA.", "output": {"entities": {"gene": [{"text": "CAT reporter gene", "start": 119, "end": 136}, {"text": "CAT protein", "start": 170, "end": 181}, {"text": "CAT mRNA", "start": 215, "end": 223}]}}, "schema": []}
{"input": "A secondary spread of an imported methicillin-resistant Staphylococcus aureus strain (MRSA) to two other patients occurred within a Danish surgical ward in spite of isolation of a multitraumatized index-patient immediately after arrival from a hospital in the Mediterranean area.", "output": {"entities": {}}, "schema": []}
{"input": "Mesial temporal sclerosis was characterized by severe neuronal loss accompanied by gliosis occurring in the CA1/prosubiculum (27 patients, 100%), focally in the dentate gyrus (12 patients, 44%), and in the CA4 region (11 patients, 41%).", "output": {"entities": {}}, "schema": []}
{"input": "Mesial temporal sclerosis.", "output": {"entities": {}}, "schema": []}
{"input": "More specific adverse events, also frequently considered as dose-limiting toxicities, include hypotension with IL-1, severe headache or skin rash with IL-3, and nasal congestion and gastroduodenal lesions with IL-4.", "output": {"entities": {"gene": [{"text": "IL-1", "start": 111, "end": 115}, {"text": "IL-3", "start": 151, "end": 155}, {"text": "IL-4", "start": 210, "end": 214}]}}, "schema": []}
{"input": "Therefore, magnetic resonance imaging was used to determine liver volume in pediatric and adolescent patients, in whom systemic clearance of three model substrates [lorazepam (0. 03 mg/kg), antipyrine (10 mg/kg), and indocyanine green (ICG; 0. 5 mg/kg)] was also determined.", "output": {"entities": {}}, "schema": []}
{"input": "A mutational analysis has resolved a region of seven amino acids (amino acids 26-32) in the N-terminus of Bob1 that are important for contacting the DNA binding POU domain of Oct-1 or Oct-2.", "output": {"entities": {"gene": [{"text": "Bob1", "start": 106, "end": 110}, {"text": "DNA binding POU domain", "start": 149, "end": 171}, {"text": "Oct-1", "start": 175, "end": 180}, {"text": "Oct-2", "start": 184, "end": 189}]}}, "schema": []}
{"input": "155 aa, shares 78% identity with the analogous region of Xenopus laevis FGF3 and 72% identity with the product of the more distantly related human gene.", "output": {"entities": {"gene": [{"text": "FGF3", "start": 72, "end": 76}]}}, "schema": []}
{"input": "The transcription start point of the proximal promoter aligns to that of mouse promoter P3 and lies within a conserved region of sequence.", "output": {"entities": {}}, "schema": []}
{"input": "A novel gene designated cmr, which mapped to 18. 8 min of the Escherichia coli K-12 genome, was shown to mediate resistance to chloramphenicol when it was expressed from a multicopy vector.", "output": {"entities": {"gene": [{"text": "cmr", "start": 24, "end": 27}]}}, "schema": []}
{"input": "In addition, 5' deletions removing all but 34 bp upstream of the transcription start point retained greater than 90% promoter activity, suggesting that the-35 hexamer was not essential for promoter activity.", "output": {"entities": {}}, "schema": []}
{"input": "The DNA sequence immediately upstream from the-10 hexamer contained the TGn motif described as an extended-10 region in prokaryotic promoters.", "output": {"entities": {}}, "schema": []}
{"input": "An apparent ufo mRNA overexpression was not found in any of the positive leukemia cell lines, but was identified in the drug-resistant subclones of the cervix carcinoma cell line HeLa.", "output": {"entities": {"gene": [{"text": "ufo mRNA", "start": 12, "end": 20}]}}, "schema": []}
{"input": "We conclude from these studies that CKII may act as a positive regulator of myogenesis by preventing E protein homodimers from binding to muscle gene regulatory elements.", "output": {"entities": {"gene": [{"text": "CKII", "start": 36, "end": 40}, {"text": "E protein homodimers", "start": 101, "end": 121}]}}, "schema": []}
{"input": "The role of negative regulators such as NCE3, as well as the previously described SIN5 gene, in determining the promoter specificity of homologous activators is discussed.", "output": {"entities": {"gene": [{"text": "NCE3", "start": 40, "end": 44}, {"text": "SIN5 gene", "start": 82, "end": 91}]}}, "schema": []}
{"input": "Transcriptional regulators utilizing the POU domain DNA-binding motif have been shown to form multi-protein complexes dependent on the POU domain itself and its flexible recognition of various octamer sequence elements.", "output": {"entities": {"gene": [{"text": "POU domain DNA-binding motif", "start": 41, "end": 69}, {"text": "POU domain", "start": 135, "end": 145}]}}, "schema": []}
{"input": "We found strand selective repair in DNA fragments within two active genes, DHFR and an unknown gene adjacent to DHFR.", "output": {"entities": {"gene": [{"text": "DHFR", "start": 75, "end": 79}, {"text": "DHFR", "start": 112, "end": 116}]}}, "schema": []}
{"input": "MATERIALS AND METHODS: Coronal 3D GRE imaging was used to study the volar, middle, and dorsal portions of the SLL in 14 patients with an arthroscopically normal SLL and in five cadaveric wrists that had a normal SLL proved with dissection.", "output": {"entities": {}}, "schema": []}
{"input": "In an effort to contribute to the transcript map of human chromosome 21 and the understanding of the pathophysiology of trisomy 21, we have used exon trapping to identify fragments of chromosome 21 genes.", "output": {"entities": {}}, "schema": []}
{"input": "Reproducing populations of this aphid were first detected in Puerto Rico in April 1992.", "output": {"entities": {}}, "schema": []}
{"input": "The model captures the essence of predator-prey dynamics to provide reasonable predictions of population patterns.", "output": {"entities": {}}, "schema": []}
{"input": "At cuticular positions exhibiting the Brd bristle loss phenotype, we have found that the progeny of the multiplied SOPs develop aberrantly, in that neurons and thecogen (sheath) cells appear but not trichogen (shaft) and tormogen (socket) cells.", "output": {"entities": {"gene": [{"text": "Brd bristle loss phenotype", "start": 38, "end": 64}]}}, "schema": []}
{"input": "Transcriptional blockade was reversed by co-transfections of a wild-type SRF expression vector, but was not rescued by the expression of other myogenic factors, such as MyoD and Mef-2C.", "output": {"entities": {"gene": [{"text": "wild-type SRF", "start": 63, "end": 76}, {"text": "MyoD", "start": 169, "end": 173}, {"text": "Mef-2C", "start": 178, "end": 184}]}}, "schema": []}
{"input": "The mMIWC1 promoter was identified and contained TATA, CAAT, GATA, and AP-2 elements; primer extension revealed mMIWC transcription initiation at 621 bp upstream from the mMIWC1 translational initiation site.", "output": {"entities": {"gene": [{"text": "mMIWC1 promoter", "start": 4, "end": 19}, {"text": "AP-2 elements", "start": 71, "end": 84}, {"text": "mMIWC", "start": 112, "end": 117}, {"text": "mMIWC1", "start": 171, "end": 177}]}}, "schema": []}
{"input": "Human MN/CA9 gene, a novel member of the carbonic anhydrase family: structure and exon to protein domain relationships.", "output": {"entities": {"gene": [{"text": "Human MN/CA9 gene", "start": 0, "end": 17}, {"text": "carbonic anhydrase family", "start": 41, "end": 66}]}}, "schema": []}
{"input": "The exon-intron distribution of Cdebp appears strikingly similar to that of the App gene in the regions encoding the conserved domains, with a divergent structure in the other parts.", "output": {"entities": {"gene": [{"text": "Cdebp", "start": 32, "end": 37}, {"text": "App gene", "start": 80, "end": 88}]}}, "schema": []}
{"input": "DNA sequence analysis reveals that the gene encodes a protein highly homologous to rat CRP1.", "output": {"entities": {"gene": [{"text": "rat CRP1", "start": 83, "end": 91}]}}, "schema": []}
{"input": "The gene was expressed as an approximately 1. 5-kb mRNA in most nonlymphoid human cells/tissues including prostate, lung, liver, and colon.", "output": {"entities": {}}, "schema": []}
{"input": "Both of these domains have striking sequence homology with human SIM and Drosophila SIM proteins.", "output": {"entities": {"gene": [{"text": "SIM", "start": 65, "end": 68}, {"text": "SIM", "start": 84, "end": 87}]}}, "schema": []}
{"input": "We have obtained the human EP4 receptor gene sequence and determined its structure relative to EP4R cDNA synthesized from peripheral blood lymphocytes.", "output": {"entities": {"gene": [{"text": "human EP4 receptor gene sequence", "start": 21, "end": 53}, {"text": "EP4R cDNA", "start": 95, "end": 104}]}}, "schema": []}
{"input": "Some users will willingly comply with management measures, other users will comply in response to education, but there will be another group who will only respond to enforcement activities.", "output": {"entities": {}}, "schema": []}
{"input": "Three separate activation subdomains, and one negative-acting region, which function in yeast were located in the carboxyl-terminal region of NIT4.", "output": {"entities": {"gene": [{"text": "NIT4", "start": 142, "end": 146}]}}, "schema": []}
{"input": "The front (F) interaction occurs ahead of the growing end of RNA.", "output": {"entities": {}}, "schema": []}
{"input": "Collectively, these data indicate that HIP is a membrane-associated HP-binding protein expressed on the surface of normal human uterine epithelia and uterine epithelial cell lines.", "output": {"entities": {"gene": [{"text": "HIP", "start": 39, "end": 42}, {"text": "HP-binding protein", "start": 68, "end": 86}]}}, "schema": []}
{"input": "The corresponding gene was identified in the GenBankTM data base by sequence alignment and termed RPS30A.", "output": {"entities": {"gene": [{"text": "RPS30A", "start": 98, "end": 104}]}}, "schema": []}
{"input": "The location of multiple GRK2 and GRK5 phosphoacceptor sites at the extreme carboxyl terminus of the beta2AR is highly reminiscent of GRK1-mediated phosphorylation of rhodopsin.", "output": {"entities": {"gene": [{"text": "GRK2", "start": 25, "end": 29}, {"text": "GRK5 phosphoacceptor sites", "start": 34, "end": 60}, {"text": "beta2AR", "start": 101, "end": 108}, {"text": "GRK1", "start": 134, "end": 138}, {"text": "rhodopsin", "start": 167, "end": 176}]}}, "schema": []}
{"input": "This regulation could not be appreciably modified by enhanced expression of STAT proteins.", "output": {"entities": {"gene": [{"text": "STAT proteins", "start": 76, "end": 89}]}}, "schema": []}
{"input": "Receptors for interleukin (IL)-10 and IL-6-type cytokines use similar signaling mechanisms for inducing transcription through IL-6 response elements.", "output": {"entities": {"gene": [{"text": "interleukin (IL)-10", "start": 14, "end": 33}, {"text": "IL-6-type cytokines", "start": 38, "end": 57}, {"text": "IL-6", "start": 126, "end": 130}]}}, "schema": []}
{"input": "Specifically, the deduced FR-19 amino acid sequence has approximately89, 77, and 68% overall identity to chicken TEF-1A, mouse TEF-1, and mouse embryonic TEA domain-containing factor, respectively.", "output": {"entities": {"gene": [{"text": "FR-19 amino acid sequence", "start": 26, "end": 51}, {"text": "chicken TEF-1A", "start": 105, "end": 119}, {"text": "mouse TEF-1", "start": 121, "end": 132}, {"text": "mouse embryonic TEA domain-containing factor", "start": 138, "end": 182}]}}, "schema": []}
{"input": "The receptor for hyaluronan mediated motility (RHAMM) gene expression is markedly elevated in fibrosarcomas exposed to transforming growth factor-beta1 (TGF-beta1).", "output": {"entities": {"gene": [{"text": "receptor for hyaluronan mediated motility (RHAMM) gene", "start": 4, "end": 58}, {"text": "transforming growth factor-beta1", "start": 119, "end": 151}, {"text": "TGF-beta1", "start": 153, "end": 162}]}}, "schema": []}
{"input": "Oncogenic Raf-1 activates p70 S6 kinase via a mitogen-activated protein kinase-independent pathway.", "output": {"entities": {"gene": [{"text": "Oncogenic Raf-1", "start": 0, "end": 15}, {"text": "p70 S6 kinase", "start": 26, "end": 39}, {"text": "mitogen-activated protein kinase", "start": 46, "end": 78}]}}, "schema": []}
{"input": "Hydropathy analysis of KCC1 indicates structural homology to NKCC, including 12 transmembrane domains, a large extracellular loop with potential N-linked glycosylation sites, and cytoplasmic N-and C-terminal regions.", "output": {"entities": {"gene": [{"text": "KCC1", "start": 23, "end": 27}, {"text": "NKCC", "start": 61, "end": 65}]}}, "schema": []}
{"input": "This protein with a hydrophobic amino terminus appears to be a secreted protein.", "output": {"entities": {}}, "schema": []}
{"input": "Notably, SRF has been found to be a key regulator of members of a class of cellular response genes termed immediate-early genes (IEGs), many of which are believed to be involved in regulating cell growth and differentiation.", "output": {"entities": {"gene": [{"text": "SRF", "start": 9, "end": 12}, {"text": "immediate-early genes", "start": 106, "end": 127}, {"text": "IEGs", "start": 129, "end": 133}]}}, "schema": []}
{"input": "The final sigma54-dependent DmpR activator regulates transcription of the dmp operon that encodes the enzymes for catabolism of (methyl) phenols.", "output": {"entities": {"gene": [{"text": "sigma54-dependent DmpR activator", "start": 10, "end": 42}, {"text": "dmp operon", "start": 74, "end": 84}]}}, "schema": []}
{"input": "In this study, we have cloned the human DSG3 gene and examined the transcriptional regulation of its expression.", "output": {"entities": {"gene": [{"text": "human DSG3 gene", "start": 34, "end": 49}]}}, "schema": []}
{"input": "Clinical evaluation of the Allergan Humphrey 500 autorefractor and the Nidek AR-1000 autorefractor.", "output": {"entities": {}}, "schema": []}
{"input": "None of the five proprotein processing proteases tested were capable of cleaving human pro-LPH, strongly suggesting that they are not involved in the maturation of this enzyme.", "output": {"entities": {"gene": [{"text": "human pro-LPH", "start": 81, "end": 94}]}}, "schema": []}
{"input": "These changes may be the result of, on the one hand, an increased sensitivity of the neuromuscular transmission and/or decreased muscle contractility and, on the other hand, the result of a reduced plasma clearance during hypothermia.", "output": {"entities": {}}, "schema": []}
{"input": "By using interleukin-3-dependent cells that ectopically express the three ErbB proteins or their combinations, we found that ErbB-3 is devoid of any biological activity but both ErbB-1 and ErbB-2 can reconstitute its extremely potent mitogenic activity.", "output": {"entities": {"gene": [{"text": "interleukin-3", "start": 9, "end": 22}, {"text": "ErbB proteins", "start": 74, "end": 87}, {"text": "ErbB-3", "start": 125, "end": 131}, {"text": "ErbB-1", "start": 178, "end": 184}, {"text": "ErbB-2", "start": 189, "end": 195}]}}, "schema": []}
{"input": "ZIOS was significantly more sensitive than all subsequent methods, and Ptc, O2 was significantly more sensitive than FEV1.", "output": {"entities": {}}, "schema": []}
{"input": "These findings suggest that direct cDNA mapping using fluorescence in situ hybridization provides an accurate and rapid approach to the definition of a transcribed map of the human genome.", "output": {"entities": {}}, "schema": []}
{"input": "YAC and cosmid contigs spanning the Batten disease (CLN3) region at 16p12. 1-p11. 2.", "output": {"entities": {"gene": [{"text": "Batten disease", "start": 36, "end": 50}, {"text": "CLN3", "start": 52, "end": 56}]}}, "schema": []}
{"input": "Isolation of a near full-length cDNA from a human fetal brain cDNA library revealed a protein serine-threonine phosphatase with a tetratricopeptide motif, almost identical to human PPP5C (PP5) and highly homologous to rat PPT.", "output": {"entities": {"gene": [{"text": "protein serine-threonine phosphatase", "start": 86, "end": 122}, {"text": "human PPP5C", "start": 175, "end": 186}, {"text": "PP5", "start": 188, "end": 191}, {"text": "rat PPT", "start": 218, "end": 225}]}}, "schema": []}
{"input": "Ly-49 is a family type II transmembrane proteins encoded by a gene cluster on murine chromosome 6.", "output": {"entities": {"gene": [{"text": "Ly-49", "start": 0, "end": 5}, {"text": "family type II transmembrane proteins", "start": 11, "end": 48}]}}, "schema": []}
{"input": "The Dox-A2 ORF driven by the TDH3 promoter complemented the phenotype of a strain deleted for sun2.", "output": {"entities": {"gene": [{"text": "Dox-A2 ORF", "start": 4, "end": 14}, {"text": "TDH3 promoter", "start": 29, "end": 42}, {"text": "sun2", "start": 94, "end": 98}]}}, "schema": []}
{"input": "The introduction of hARF4 to the cells maintained the balance between cytosolic and membrane-associated Sec7p pools.", "output": {"entities": {"gene": [{"text": "hARF4", "start": 20, "end": 25}, {"text": "Sec7p", "start": 104, "end": 109}]}}, "schema": []}
{"input": "Vacuolar membrane vesicles from hum1 mutants lack all Ca2 +/H + antiport activity, demonstrating that Hum1p catalyzes the exchange of Ca2 + for H + across the yeast vacuolar membrane.", "output": {"entities": {"gene": [{"text": "hum1 mutants", "start": 32, "end": 44}, {"text": "Hum1p", "start": 102, "end": 107}]}}, "schema": []}
{"input": "Detailed mutagenesis of the element' s rare-codon/AU-rich sequence boundary revealed that the destabilizing activity of the MATalpha1 IE is observed when the terminal codon of the element' s rare-codon interval is translated.", "output": {"entities": {"gene": [{"text": "MATalpha1 IE", "start": 124, "end": 136}]}}, "schema": []}
{"input": "FTF is also abundantly expressed in the pancreas and may exert differentiation functions in endodermal sublineages, similar to SF-1 in steroidogenic tissues.", "output": {"entities": {"gene": [{"text": "FTF", "start": 0, "end": 3}, {"text": "SF-1", "start": 127, "end": 131}]}}, "schema": []}
{"input": "The incidence of cardiac death (one per group), Q wave MI (propofol, n = 7; midazolam, n = 3; P = 0. 27), or non Q wave MI (propofol, n = 16; midazolam, n = 18; P = 0. 81) did not differ between treatment groups.", "output": {"entities": {}}, "schema": []}
{"input": "Cluster formation of E-cadherin on the cell surface is believed to be of major importance for cell-cell adhesion.", "output": {"entities": {"gene": [{"text": "E-cadherin", "start": 21, "end": 31}]}}, "schema": []}
{"input": "DNA polymerase E, DNA ligase III and a DNA structure-specific endonuclease co-purify with the five polypeptide complex.", "output": {"entities": {"gene": [{"text": "DNA polymerase E", "start": 0, "end": 16}, {"text": "DNA ligase III", "start": 18, "end": 32}]}}, "schema": []}
{"input": "By using reporter gene constructs, it is shown that upstream sequences of the P1 promoter contain several regions that modulate the expression either positively or negatively.", "output": {"entities": {}}, "schema": []}
{"input": "The factor structure of \" schizotypal' traits: a large replication study.", "output": {"entities": {}}, "schema": []}
{"input": "Interestingly, however, it is homologous to several expressed sequence tags (EST) of unknown function from Caenorhabditis elegans, Oryza sativa and Homo sapiens.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: The bilinear model provided a significantly better fit to the acuity outcome data.", "output": {"entities": {}}, "schema": []}
{"input": "Outcome of severe congenital hypothyroidism.", "output": {"entities": {}}, "schema": []}
{"input": "Nonreturn rates can be used to derive more elementary biological measures for reproductive efficiency, such as conception rate and calving rate, which separately might be more reliable than nonreturn rate itself to evaluate the fertility of a bull or the performance of an AI technician.", "output": {"entities": {}}, "schema": []}
{"input": "However, if EMPD involves the glans penis or perianal area, a search for internal malignancy is still warranted.", "output": {"entities": {}}, "schema": []}
{"input": "The mean values of protease activity were significantly higher in the test groups than in the control group at baseline.", "output": {"entities": {}}, "schema": []}
{"input": "Each half molecule contains four disulfide linkages and four cis peptides.", "output": {"entities": {}}, "schema": []}
{"input": "Only fully processed Pra (N0 and Nb) and ICP35 (ICP35 e, f) are present in B capsids, which are believed to be precursors of mature virions.", "output": {"entities": {"gene": [{"text": "Pra", "start": 21, "end": 24}, {"text": "ICP35", "start": 41, "end": 46}, {"text": "ICP35 e, f", "start": 48, "end": 58}]}}, "schema": []}
{"input": "However, one 3' splice site, located at nucleotide (nt) 3225, is used for the processing of most BPV-1 pre-mRNAs in BPV-1-transformed C127 cells and at early to intermediate times in productively infected warts.", "output": {"entities": {}}, "schema": []}
{"input": "Here, the cloning and characterization of S-RNase genes from two species of Rosaceae, apple (Malus x domestica) and Japanese pear (Pyrus serotina) is described and these sequences are compared with those of other T2-type RNases.", "output": {"entities": {"gene": [{"text": "S-RNase genes", "start": 42, "end": 55}, {"text": "T2-type RNases", "start": 213, "end": 227}]}}, "schema": []}
{"input": "A phylogenetic tree of members of the T2/S-RNase superfamily in plants was obtained.", "output": {"entities": {"gene": [{"text": "T2/S-RNase superfamily", "start": 38, "end": 60}]}}, "schema": []}
{"input": "In a Hoosier Oncology Group randomized study involving extensive-disease SCLC patients, VIP was superior to etoposide/cisplatin with regard to median time to progression (6. 6 v 5. 8 months), median survival times (9. 1 v 7. 3 months), and 2-and 3-year survival rates (13% v 5% and 5% v 0%, respectively).", "output": {"entities": {}}, "schema": []}
{"input": "It was shown that administration of immunomodulator neurotropin (NSP) results in more steady consolidation and retention of feeding and avoidance behavior, and some neurophysiological mechanisms of that phenomena were revealed.", "output": {"entities": {"gene": [{"text": "neurotropin", "start": 52, "end": 63}, {"text": "NSP", "start": 65, "end": 68}]}}, "schema": []}
{"input": "Sestamibi scintigraphy, performed in 70 patients, was less sensitive than ultrasonography (80%).", "output": {"entities": {}}, "schema": []}
{"input": "Atopic allergy and other hypersensitivities.", "output": {"entities": {}}, "schema": []}
{"input": "After 6 h of reperfusion, PO2/FlO2 ratio was significantly better after Combined Therapy (372 +/-52 mm Hg) than in the Recipient Instilled (117 +/-47 mm Hg) and Control groups (87 +/-26 mm Hg), with intermediate values in Donor Aerosol dogs (232 +/-64 mm Hg).", "output": {"entities": {}}, "schema": []}
{"input": "The euglobulin clot lysis time was slightly longer in the smokers than in the non-smokers in all three experimental situations, but the differences were not significant.", "output": {"entities": {"gene": [{"text": "euglobulin", "start": 4, "end": 14}]}}, "schema": []}
{"input": "HS inducibility required the HSE which was bound by HS transcription factor-1 (HSF-1) present in extracts prepared from cells exposed to HS.", "output": {"entities": {"gene": [{"text": "HS transcription factor-1", "start": 52, "end": 77}, {"text": "HSF-1", "start": 79, "end": 84}]}}, "schema": []}
{"input": "Although the DSK2-1 mutation alters a conserved residue in the Dsk2p ubiquitin-like domain, we detect no differences in Dsk2p or Cdc31p stability.", "output": {"entities": {"gene": [{"text": "DSK2-1 mutation", "start": 13, "end": 28}, {"text": "Dsk2p ubiquitin-like domain", "start": 63, "end": 90}, {"text": "Dsk2p", "start": 120, "end": 125}, {"text": "Cdc31p", "start": 129, "end": 135}]}}, "schema": []}
{"input": "Consistent with this interpretation, recombinant CREB and activating transcription factor proteins bound the junB CRE-like site, but did not interact with a mutant CRE-like site.", "output": {"entities": {"gene": [{"text": "recombinant CREB", "start": 37, "end": 53}, {"text": "activating transcription factor proteins", "start": 58, "end": 98}, {"text": "junB", "start": 109, "end": 113}]}}, "schema": []}
{"input": "Collectively, these results suggest that components of the protein kinase A signaling pathway are recruited by mIg to induce junB transcription.", "output": {"entities": {"gene": [{"text": "protein kinase A", "start": 59, "end": 75}, {"text": "mIg", "start": 111, "end": 114}, {"text": "junB", "start": 125, "end": 129}]}}, "schema": []}
{"input": "Immunofluorescence microscopy revealed extensive deposition of such extracellular matrices as type IV collagen and laminin in the vascular wall.", "output": {"entities": {"gene": [{"text": "type IV collagen", "start": 94, "end": 110}, {"text": "laminin", "start": 115, "end": 122}]}}, "schema": []}
{"input": "OBJECTIVE: To compare pregnancy complications in women having genetic amniocentesis at 11-14 weeks versus those undergoing amniocentesis at 16-19 weeks' gestation.", "output": {"entities": {}}, "schema": []}
{"input": "Three ORFs (9765orfR002, 9765orfR011 and 9765orfR013) were found to be homologous with Schizosaccharomyces pombe polyadenylate binding protein, Escherichia coli hypothetical 38. 1-kDa protein in the BCR 5' region, and transcription regulatory protein Swi3, respectively.", "output": {"entities": {"gene": [{"text": "polyadenylate binding protein", "start": 113, "end": 142}, {"text": "BCR", "start": 199, "end": 202}, {"text": "Swi3", "start": 251, "end": 255}]}}, "schema": []}
{"input": "Two new flavone glucosides, nevadensin 5-O-beta-D-glucoside and nevadensin 5-O-beta-D-glucosyl (1--> 6) beta-D-glucoside, have been isolated from the aerial parts of Lysionotus pauciflorus.", "output": {"entities": {}}, "schema": []}
{"input": "Recently, our laboratory developed a screen that identified five multicopy suppressors that can rescue lethal strains of clathrin heavy chain-deficient yeast (Chc-scd1-i) to viability.", "output": {"entities": {"gene": [{"text": "clathrin", "start": 121, "end": 129}, {"text": "Chc", "start": 159, "end": 162}, {"text": "scd1-i", "start": 163, "end": 169}]}}, "schema": []}
{"input": "Reproductive period affects water intake in heat-stressed dehydrated goats.", "output": {"entities": {}}, "schema": []}
{"input": "The logistic regression analysis of the manual method (percentage normal morphology) and IVOS indicated that both were predictors of fertilization.", "output": {"entities": {}}, "schema": []}
{"input": "METHODS: Rats received continuous intragastric infusion of elemental diet or with supplementation of oatbase, Lactobacillus reuteri R2LC, and Lactobacillus plantarum DSM 9843, with and without fermentation, from the beginning of the study.", "output": {"entities": {}}, "schema": []}
{"input": "However, D8 binding was observed by nuclease protection with lactotroph-as well as somatotroph-like cell nuclear protein.", "output": {"entities": {"gene": [{"text": "D8", "start": 9, "end": 11}, {"text": "lactotroph-as well as somatotroph-like cell nuclear protein", "start": 61, "end": 120}]}}, "schema": []}
{"input": "The ability of A20 to block NF-kappaB activation was mapped to its C-terminal zinc finger domain.", "output": {"entities": {"gene": [{"text": "A20", "start": 15, "end": 18}, {"text": "NF-kappaB", "start": 28, "end": 37}]}}, "schema": []}
{"input": "By using a DNA sequence selected for its ability to bind recombinant BCL-6 in vitro, we show here that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines.", "output": {"entities": {"gene": [{"text": "recombinant BCL-6", "start": 57, "end": 74}, {"text": "BCL-6", "start": 103, "end": 108}]}}, "schema": []}
{"input": "The predictive value of a positive flag was 77. 7%.", "output": {"entities": {}}, "schema": []}
{"input": "Because chromosome X is frequently involved in structural alterations in neoplastic Syrian hamster cells transformed by chemical carcinogens and oncogenic viruses, the localization of the cph locus on this chromosome supports the notion that the cph oncogene plays a role in the malignant conversion of chemically transformed hamster fibroblasts.", "output": {"entities": {"gene": [{"text": "cph locus", "start": 188, "end": 197}, {"text": "cph oncogene", "start": 246, "end": 258}]}}, "schema": []}
{"input": "Gap1 (IP4BP), one of a member of Ras GTPase-activating proteins, has been identified as a specific inositol 1, 3, 4, 5-tetrakisphosphate (IP4)-binding protein (Cullen, P.", "output": {"entities": {"gene": [{"text": "Gap1 (IP4BP)", "start": 0, "end": 12}, {"text": "Ras GTPase-activating proteins", "start": 33, "end": 63}, {"text": "inositol 1, 3, 4, 5-tetrakisphosphate (IP4)-binding protein", "start": 99, "end": 158}]}}, "schema": []}
{"input": "We previously described the purification of an 83-kDa phosphatidic acid phosphatase (PAP) from the porcine thymus membranes (Kanoh, H., Imai, S.-i., Yamada, K. and Sakane, F. (1992) J.", "output": {"entities": {"gene": [{"text": "83-kDa phosphatidic acid phosphatase", "start": 47, "end": 83}, {"text": "PAP", "start": 85, "end": 88}]}}, "schema": []}
{"input": "A cDNA encoding the amino-terminal 17% of apoB (apoB17) was fused to a cDNA coding for the last 37 amino acids of decay-accelerating factor (DAF), which contains the signal for glycosylphosphatidylinositol anchor attachment.", "output": {"entities": {"gene": [{"text": "apoB", "start": 42, "end": 46}, {"text": "apoB17", "start": 48, "end": 54}, {"text": "decay-accelerating factor", "start": 114, "end": 139}, {"text": "DAF", "start": 141, "end": 144}]}}, "schema": []}
{"input": "Next, we stably overexpressed wild-type Shc or Y317F mutant Shc into HIRc cells.", "output": {"entities": {"gene": [{"text": "wild-type Shc", "start": 30, "end": 43}, {"text": "Y317F mutant Shc", "start": 47, "end": 63}]}}, "schema": []}
{"input": "The small GTPase Rho is implicated in physiological functions associated with actin-myosin filaments such as cytokinesis, cell motility, and smooth muscle contraction.", "output": {"entities": {"gene": [{"text": "small GTPase Rho", "start": 4, "end": 20}, {"text": "actin", "start": 78, "end": 83}, {"text": "myosin", "start": 84, "end": 90}]}}, "schema": []}
{"input": "Conversely, activation of this signaling pathway by expression of a constitutively active MKK1 mutant dramatically increased cyclin D1 promoter activity and cyclin D1 protein expression, in a growth factor-independent manner.", "output": {"entities": {"gene": [{"text": "MKK1 mutant", "start": 90, "end": 101}, {"text": "cyclin D1", "start": 125, "end": 134}, {"text": "cyclin D1 protein", "start": 157, "end": 174}]}}, "schema": []}
{"input": "Furthermore, upstream insertion of the GSTP1 silencer element failed to inhibit activity of a heterologous promoter in MCF7 cells.", "output": {"entities": {"gene": [{"text": "GSTP1 silencer element", "start": 39, "end": 61}]}}, "schema": []}
{"input": "In order to delineate structural motifs regulating substrate affinity and recognition for the human dopamine transporter (DAT), we assessed [3H] dopamine uptake kinetics and [3H] CFT binding characteristics of COS-7 cells transiently expressing mutant DATs in which the COOH terminus was truncated or substituted.", "output": {"entities": {"gene": [{"text": "human dopamine transporter", "start": 94, "end": 120}, {"text": "DAT", "start": 122, "end": 125}, {"text": "mutant DATs", "start": 245, "end": 256}]}}, "schema": []}
{"input": "An expression library was constructed by inserting 5' portion-enriched cDNAs from phytohemagglutinin-stimulated peripheral blood mononuclear cells into upstream of signal sequence-deleted CD4 cDNA in an Epstein-Barr virus shuttle vector.", "output": {"entities": {"gene": [{"text": "phytohemagglutinin", "start": 82, "end": 100}, {"text": "signal sequence-deleted CD4 cDNA", "start": 164, "end": 196}]}}, "schema": []}
{"input": "Radiolabeled recombinant TARC specifically bound to T cell lines and peripheral T cells but not to monocytes or granulocytes.", "output": {"entities": {"gene": [{"text": "recombinant TARC", "start": 13, "end": 29}]}}, "schema": []}
{"input": "Therefore, we have identified a cis-acting element, the E1 E-box, located in the GAP-43 promoter region that modulates either positively or negatively the expression of the GAP-43 gene depending on which E-box-binding proteins occupy this site.", "output": {"entities": {"gene": [{"text": "GAP-43", "start": 81, "end": 87}, {"text": "GAP-43 gene", "start": 173, "end": 184}, {"text": "E-box-binding proteins", "start": 204, "end": 226}]}}, "schema": []}
{"input": "Collectively, our findings demonstrate that SF-1 plays a key role in controlling the basal and cAMP-stimulated expression of the StAR gene.", "output": {"entities": {"gene": [{"text": "SF-1", "start": 44, "end": 48}, {"text": "StAR gene", "start": 129, "end": 138}]}}, "schema": []}
{"input": "Using one of the six fragments (CPK3-8), we isolated a 2022 bp cDNA (VrCDPK-1) from a Vigna radiata lambda gt11 library.", "output": {"entities": {"gene": [{"text": "CPK3-8", "start": 32, "end": 38}, {"text": "2022 bp cDNA (VrCDPK-1)", "start": 55, "end": 78}]}}, "schema": []}
{"input": "However, in TF-1 cells grown on GM-CSF before starvation, CREB phosphorylation was observed 10 minutes after PIXY321 stimulation.", "output": {"entities": {"gene": [{"text": "GM-CSF", "start": 32, "end": 38}, {"text": "CREB", "start": 58, "end": 62}, {"text": "PIXY321", "start": 109, "end": 116}]}}, "schema": []}
{"input": "Workplace violence--nurses at risk.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: The LV maximum brightness and area under the curve showed significant negative correlations (p = < 0. 004) with the FIO2, while the minimum brightness showed a significant positive correlation (p = < 0. 002).", "output": {"entities": {}}, "schema": []}
{"input": "The results also imply that the absence of perforin expression in non-cytotoxic cells may be due to the suppression of the induction of the killer-cell-specific trans-acting factor NF-P2.", "output": {"entities": {"gene": [{"text": "perforin", "start": 43, "end": 51}, {"text": "NF-P2", "start": 181, "end": 186}]}}, "schema": []}
{"input": "We identify considerable spatio-temporal similarities between reported expression patterns of Ypr10 genes and ribonuclease genes, which, together with the significant sequence similarity to the ginseng ribonuclease, support the hypothesis of a ribonuclease function for PR-10 proteins and allow the prediction of possible biological roles.", "output": {"entities": {"gene": [{"text": "Ypr10 genes", "start": 94, "end": 105}, {"text": "ginseng ribonuclease", "start": 194, "end": 214}, {"text": "PR-10 proteins", "start": 270, "end": 284}]}}, "schema": []}
{"input": "The expression of ERV3 env mRNA was found to be differentiation-associated, with high expression detected in the late stages of monocytic development.", "output": {"entities": {"gene": [{"text": "ERV3 env mRNA", "start": 18, "end": 31}]}}, "schema": []}
{"input": "Initial estimates indicate that 27, 193 people are either in receipt of or in need of mental handicap services.", "output": {"entities": {}}, "schema": []}
{"input": "It is exclusively observed in smooth muscle cells by Northern blotting and immunohistochemical analysis and therefore designated \" smoothelin. \" A human smooth muscle cDNA library was screened with the monoclonal antibody R4A, and a full-size cDNA of the protein was selected.", "output": {"entities": {"gene": [{"text": "\" smoothelin. \"", "start": 129, "end": 144}, {"text": "monoclonal antibody R4A", "start": 202, "end": 225}]}}, "schema": []}
{"input": "Concurrent with ligand-dependent uptake, we now show that the receptor undergoes ligand-induced ubiquitination, suggesting that receptor ubiquitination may function in the ligand-dependent endocytosis of the a-factor receptor as well as in its constitutive endocytosis.", "output": {"entities": {"gene": [{"text": "a-factor receptor", "start": 208, "end": 225}]}}, "schema": []}
{"input": "Epstein-Barr virus nuclear protein 2 (EBNA2) binds to a component of the human SNF-SWI complex, hSNF5/Ini1.", "output": {"entities": {"gene": [{"text": "Epstein-Barr virus nuclear protein 2", "start": 0, "end": 36}, {"text": "EBNA2", "start": 38, "end": 43}, {"text": "SNF", "start": 79, "end": 82}, {"text": "SWI", "start": 83, "end": 86}, {"text": "hSNF5", "start": 96, "end": 101}, {"text": "Ini1", "start": 102, "end": 106}]}}, "schema": []}
{"input": "Our studies also excluded the possibility that the phosphorylation of Ser-2, Ser-123, or Ser-210, had roles in the trans-suppression activity of the large HDAg, in the assembly of empty virus-like HDAg particle, and in the nuclear transport of HDAgs.", "output": {"entities": {"gene": [{"text": "large HDAg", "start": 149, "end": 159}, {"text": "virus-like HDAg particle", "start": 186, "end": 210}, {"text": "HDAgs", "start": 244, "end": 249}]}}, "schema": []}
{"input": "Homologous recombination between the Autographa californica nuclear polyhedrosis virus (AcNPV) genome and a 0. 6-kbp-long DNA fragment derived from the putative DNA helicase gene of Bombyx mori nuclear polyhedrosis virus generates eh2-AcNPV, an expanded-host-range AcNPV mutant (S.", "output": {"entities": {"gene": [{"text": "DNA helicase gene of Bombyx mori nuclear polyhedrosis virus", "start": 161, "end": 220}]}}, "schema": []}
{"input": "The data further indicate that the IL-7R alpha chains are directly involved in the activation of JAKs and STATs and have a major role in proliferative signaling in precursor B cells.", "output": {"entities": {"gene": [{"text": "IL-7R alpha chains", "start": 35, "end": 53}, {"text": "JAKs", "start": 97, "end": 101}, {"text": "STATs", "start": 106, "end": 111}]}}, "schema": []}
{"input": "Furthermore, the potency of Dacarbacine in the treatment of carcinoid tumors seems to be underestimated up to now.", "output": {"entities": {}}, "schema": []}
{"input": "5) We' ve noticed that the mean value of the cost for episode of pnx s. in class A was more than 15% compared to class B and the cost for patient in class A was nearly double than in class B.", "output": {"entities": {}}, "schema": []}
{"input": "Cbl constitutively interacts with the SH3 domains of Grb2, with a preference for the amino-terminal domain, and is in this way recruited to Shc upon BCR stimulation.", "output": {"entities": {"gene": [{"text": "Cbl", "start": 0, "end": 3}, {"text": "SH3 domains", "start": 38, "end": 49}, {"text": "Grb2", "start": 53, "end": 57}, {"text": "Shc", "start": 140, "end": 143}, {"text": "BCR", "start": 149, "end": 152}]}}, "schema": []}
{"input": "Activation mediated by Cat8p was no longer detectable in a cat1 mutant.", "output": {"entities": {"gene": [{"text": "Cat8p", "start": 23, "end": 28}, {"text": "cat1 mutant", "start": 59, "end": 70}]}}, "schema": []}
{"input": "Treatment is instituted with prednisone and cyclophosphamide.", "output": {"entities": {}}, "schema": []}
{"input": "Laboratory evaluation was normal, and neuroimaging failed to confirm obstruction of venous or lymphatic drainage.", "output": {"entities": {}}, "schema": []}
{"input": "Microcomputer management of chronic hepatitis B virus asymptomatic patients", "output": {"entities": {}}, "schema": []}
{"input": "While fusion to the N-terminus required a linker to become surface accessible, both fusion to the N-terminus and to the C-terminus was compatible with particle assembly and preserved the native antigenicity and immunogenicity of HBcAg.", "output": {"entities": {"gene": [{"text": "HBcAg", "start": 229, "end": 234}]}}, "schema": []}
{"input": "The standard dosage of anti-D currently given at all gestational ages is 1 ampoule containing 125 micrograms of anti-D.", "output": {"entities": {"gene": [{"text": "anti-D", "start": 23, "end": 29}, {"text": "anti-D", "start": 112, "end": 118}]}}, "schema": []}
{"input": "We report here the molecular cloning of a putative adhesive molecule from P. falciparum that shares both sequence and structural similarities with a sporozoite surface molecule from Plasmodium termed the thrombospondin-related anonymous protein (TRAP) and, to a lesser extent, with the circumsporozoite (CS) protein.", "output": {"entities": {"gene": [{"text": "thrombospondin-related anonymous protein", "start": 204, "end": 244}, {"text": "TRAP", "start": 246, "end": 250}, {"text": "circumsporozoite (CS) protein", "start": 286, "end": 315}]}}, "schema": []}
{"input": "There are no introns within the gene, which contains a 9360-bp open reading frame and encodes a 377-kDa protein.", "output": {"entities": {}}, "schema": []}
{"input": "METHODS: DSF was instilled in one eye chosen at random and CF in the fellow eye of 13 normal subjects and in 13 patients with KCS.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSION: The results demonstrate that at the site of lumbar disc herniation, inflammatory cytokines such as interleukin-1 alpha are produced, which increases prostaglandin E2 production.", "output": {"entities": {"gene": [{"text": "interleukin-1 alpha", "start": 111, "end": 130}]}}, "schema": []}
{"input": "The predominant sensitizing allergens in Swedish asthmatic children are furred pet animals.", "output": {"entities": {}}, "schema": []}
{"input": "Our results demonstrate that distinct cytoplasmic domains of these cytokine receptors elicit convergent signaling pathways and provide evidence that beta c and IL-2R beta function as a complete signal transducer.", "output": {"entities": {"gene": [{"text": "beta c", "start": 149, "end": 155}, {"text": "IL-2R beta", "start": 160, "end": 170}]}}, "schema": []}
{"input": "In addition, they display common features that make them strikingly related to snoRNA U14.", "output": {"entities": {"gene": [{"text": "snoRNA U14", "start": 79, "end": 89}]}}, "schema": []}
{"input": "U24 has two separate 12 nt long complementarities to a highly conserved tract of 28S rRNA.", "output": {"entities": {"gene": [{"text": "U24", "start": 0, "end": 3}, {"text": "28S rRNA", "start": 81, "end": 89}]}}, "schema": []}
{"input": "This complex interacts at the GTPase domain in the large subunit rRNA, overlapping the binding site of the protein L11-like eukaryotic counterpart (Saccharomyces cerevisiae protein L15 and mammalian protein L12).", "output": {"entities": {"gene": [{"text": "GTPase domain", "start": 30, "end": 43}, {"text": "protein L11-like eukaryotic counterpart", "start": 107, "end": 146}, {"text": "Saccharomyces cerevisiae protein L15", "start": 148, "end": 184}, {"text": "mammalian protein L12", "start": 189, "end": 210}]}}, "schema": []}
{"input": "Chromatin repression of these replacement genes would be avoided, consistent with the high, constitutive expression of replacement H3 histone genes in plants.", "output": {"entities": {"gene": [{"text": "H3 histone genes", "start": 131, "end": 147}]}}, "schema": []}
{"input": "This transition is regulated positively by G1-specific cyclin-dependent kinases (cdks) and negatively by the product of the retinoblastoma tumour suppressor gene, pRb.", "output": {"entities": {"gene": [{"text": "G1-specific cyclin-dependent kinases", "start": 43, "end": 79}, {"text": "cdks", "start": 81, "end": 85}, {"text": "retinoblastoma tumour suppressor gene", "start": 124, "end": 161}, {"text": "pRb", "start": 163, "end": 166}]}}, "schema": []}
{"input": "To derive quantitative concentration changes from measurements of light attenuation, the optical path length must be known.", "output": {"entities": {}}, "schema": []}
{"input": "STUDY DESIGN.", "output": {"entities": {}}, "schema": []}
{"input": "Following the injection of PGF2 alpha, heifers were observed visually for signs of estrus at 0730 and 1630 (45 min each).", "output": {"entities": {}}, "schema": []}
{"input": "Differential activation of the extracellular signal-regulated kinase, Jun kinase and Janus kinase-Stat pathways by oncostatin M and basic fibroblast growth factor in AIDS-derived Kaposi' s sarcoma cells.", "output": {"entities": {"gene": [{"text": "extracellular signal-regulated kinase", "start": 31, "end": 68}, {"text": "Jun kinase", "start": 70, "end": 80}, {"text": "Janus kinase", "start": 85, "end": 97}, {"text": "Stat", "start": 98, "end": 102}, {"text": "oncostatin M", "start": 115, "end": 127}, {"text": "basic fibroblast growth factor", "start": 132, "end": 162}]}}, "schema": []}
{"input": "There is general agreement that the hepatitis C virus is efficiently transmitted parenterally, while data on viral transmission from mothers to babies or by sexual or non-sexual household contact are conflicting.", "output": {"entities": {}}, "schema": []}
{"input": "Ten weeks after reconstruction, the regenerating nerves already resembled normal nerves.", "output": {"entities": {}}, "schema": []}
{"input": "The distribution and organization of projections from the spinal cervical enlargement to subnucleus reticularis dorsalis (SRD) and the neighbouring Cuneate nucleus (Cu) area was studied in the rat by using microinjections of Phaseolus vulgaris leucoagglutinin (PHA-L) into different laminae around the C7 level.", "output": {"entities": {"gene": [{"text": "Phaseolus vulgaris leucoagglutinin", "start": 225, "end": 259}, {"text": "PHA-L", "start": 261, "end": 266}]}}, "schema": []}
{"input": "The levels of fibrinogen as well as antithrombin III (ATIII) and heparin cofactor II (HCII) activities were steadily increased in loop-bearing animals.", "output": {"entities": {"gene": [{"text": "fibrinogen", "start": 14, "end": 24}, {"text": "antithrombin III", "start": 36, "end": 52}, {"text": "ATIII", "start": 54, "end": 59}, {"text": "heparin cofactor II", "start": 65, "end": 84}, {"text": "HCII", "start": 86, "end": 90}]}}, "schema": []}
{"input": "Amplification and overexpression of the c-erbB-2 gene in 21MT-2 and 21MT-1 human breast carcinoma cells results in progressively elevated levels of constitutively tyrosine-phosphorylated p185erbB-2 and is associated with progressive insulin-like growth factor (IGF) and combined IGF/epidermal growth factor (EGF) independence in culture.", "output": {"entities": {"gene": [{"text": "c-erbB-2 gene", "start": 40, "end": 53}, {"text": "tyrosine-phosphorylated p185erbB-2", "start": 163, "end": 197}, {"text": "insulin-like growth factor", "start": 233, "end": 259}, {"text": "IGF", "start": 261, "end": 264}, {"text": "IGF", "start": 279, "end": 282}, {"text": "epidermal growth factor", "start": 283, "end": 306}, {"text": "EGF", "start": 308, "end": 311}]}}, "schema": []}
{"input": "Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant, neuromuscular disorder characterized by progressive weakness of muscles in the face, shoulder and upper arm.", "output": {"entities": {}}, "schema": []}
{"input": "The mature chromosome 4 FRG1 transcript is 1042 bp in length and contains nine exons which encode a putative protein of 258 amino acid residues.", "output": {"entities": {"gene": [{"text": "FRG1 transcript", "start": 24, "end": 39}]}}, "schema": []}
{"input": "Patients who have undergone thyroidectomy for thyroid carcinoma are frequently subjected to periods of induced severe hypothyroidism in preparation for 131I whole body scanning and measurement of serum TG.", "output": {"entities": {"gene": [{"text": "TG", "start": 202, "end": 204}]}}, "schema": []}
{"input": "Full thyroid function testing was performed on 600 randomly selected samples with normal TSH values and also on subjects with abnormal TSH levels.", "output": {"entities": {"gene": [{"text": "TSH", "start": 89, "end": 92}, {"text": "TSH", "start": 135, "end": 138}]}}, "schema": []}
{"input": "In a third experiment, crossover AM between dissimilar textures was investigated, and it was found that the more salient textures carried the AM.", "output": {"entities": {}}, "schema": []}
{"input": "The relative tumor FDG-uptake (Q-MRGlu) (tumor/contralateral cortex) of all meningiomas was calculated with 0. 73 +/-0. 37 (0. 24-1. 79).", "output": {"entities": {}}, "schema": []}
{"input": "Zatebradine weakly depressed the ectopic ventricular rate but not the arrhythmic ratio of the ventricular arrhythmias induced by two-stage coronary ligation 24 h after the ligation in conscious dogs.", "output": {"entities": {}}, "schema": []}
{"input": "Catha edulis, a plant that has amphetamine effects.", "output": {"entities": {}}, "schema": []}
{"input": "The predicted protein, Seb1p, consists of 82 amino acids and contains one potential membrane-spanning region at the C-terminus but no N-terminal signal sequence.", "output": {"entities": {"gene": [{"text": "Seb1p", "start": 23, "end": 28}]}}, "schema": []}
{"input": "The SEB1 homologue thus isolated, SEB2, encodes a protein 53% identical to Seb1p.", "output": {"entities": {"gene": [{"text": "SEB1", "start": 4, "end": 8}, {"text": "SEB2", "start": 34, "end": 38}, {"text": "Seb1p", "start": 75, "end": 80}]}}, "schema": []}
{"input": "Nonetheless, that ventricular afferents, in certain special settings, are able to induce e. g. generalised vasodilation and hypotension cannot be excluded.", "output": {"entities": {}}, "schema": []}
{"input": "Large ones were similar in size to the main lobe and small ones were approximately 1/4 of the length of the main lobe.", "output": {"entities": {}}, "schema": []}
{"input": "Fragments and analogs of the hormone ACTH were previously shown to have beneficial effect on the outcome of head injury, while elevated levels of corticosterone (CS) exacerbate it.", "output": {"entities": {"gene": [{"text": "ACTH", "start": 37, "end": 41}]}}, "schema": []}
{"input": "Fifty-one patients with primary refractory or relapsed malignant lymphoma (47 non-Hodgkin' s lymphoma and four Hodgkin' s disease) were treated with a new chemotherapeutic regimen (cisplatinum, methyl GAG, bleomocyin, methyl prednisolon).", "output": {"entities": {}}, "schema": []}
{"input": "With the increasing use of ACE inhibitors, the incidence of rare adverse effects such as potentially lethal pancreatitis is likely to increase.", "output": {"entities": {"gene": [{"text": "ACE", "start": 27, "end": 30}]}}, "schema": []}
{"input": "In 3 treatments the diet was supplemented with 0, 100 and 150 mg probiotic/kg food.", "output": {"entities": {}}, "schema": []}
{"input": "Low-dose aspirin and recurrent miscarriage.", "output": {"entities": {}}, "schema": []}
{"input": "Protein films are distinctly different in mechanical profiles from those films made of other materials.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, cpxA * mutations suppress the toxicity conferred by the LamB-LacZ hybrid protein, which exerts its effects in the cytoplasm, sequestered from DegP.", "output": {"entities": {"gene": [{"text": "cpxA *", "start": 13, "end": 19}, {"text": "LamB", "start": 69, "end": 73}, {"text": "LacZ", "start": 74, "end": 78}, {"text": "DegP", "start": 155, "end": 159}]}}, "schema": []}
{"input": "The PI3K _ 68D cDNA encodes a protein of 210 kDa, which lacks sequences implicated in linking p110 PI 3-kinases to p85 adaptor proteins, but contains an amino-terminal proline-rich sequence, which could bind to SH3 domains, and a carboxy-terminal C2 domain.", "output": {"entities": {"gene": [{"text": "PI3K _ 68D cDNA", "start": 4, "end": 19}, {"text": "p110 PI 3-kinases", "start": 94, "end": 111}, {"text": "p85 adaptor proteins", "start": 115, "end": 135}, {"text": "SH3 domains", "start": 211, "end": 222}, {"text": "C2", "start": 247, "end": 249}]}}, "schema": []}
{"input": "AIMS/METHODS: Reticuloendothelial system function, as assessed by clearance of radiolabelled bacteria, was evaluated in acute liver injury induced by D-galactosamine in rats, and compared with that after 70% liver resection model.", "output": {"entities": {}}, "schema": []}
{"input": "Our laboratory and others have shown alternative splicing of up to ten exons at a discrete extracellular site to be primarily responsible for the generation of CD44 variant (CD44v) isoforms.", "output": {"entities": {"gene": [{"text": "CD44 variant", "start": 160, "end": 172}, {"text": "CD44v", "start": 174, "end": 179}]}}, "schema": []}
{"input": "Study groups were control, and those treated with the alpha1-adrenoceptor-subtype blockers WB4101 (0. 5 mg/kg i. v.) or chloroethylclonidine (1. 9 mg/kg i. v.).", "output": {"entities": {"gene": [{"text": "alpha1-adrenoceptor-subtype", "start": 54, "end": 81}]}}, "schema": []}
{"input": "This caused severe cortical damage and neuronal loss in hippocampus subfields CA1, CA3, and hilus.", "output": {"entities": {}}, "schema": []}
{"input": "The occurrence of multiple malignancy was studied in 674 patients with hematologic malignancies who were admitted to this department during the past 10 years.", "output": {"entities": {}}, "schema": []}
{"input": "The upTRE binds more T3R homodimers and less T3R-RXR heterodimers than the dnTRE, and T3 more readily facilitates heterodimer binding to the dn-than to the upTRE.", "output": {"entities": {"gene": [{"text": "T3R homodimers", "start": 21, "end": 35}, {"text": "T3R", "start": 45, "end": 48}, {"text": "RXR", "start": 49, "end": 52}]}}, "schema": []}
{"input": "Transcriptional control of a nuclear gene encoding a mitochondrial fatty acid oxidation enzyme in transgenic mice: role for nuclear receptors in cardiac and brown adipose expression.", "output": {"entities": {}}, "schema": []}
{"input": "Hoeben, F. J.", "output": {"entities": {}}, "schema": []}
{"input": "Moreover, glucan synthase activity, which is activated by Rho1p, was significantly reduced in the deltabem4 mutant.", "output": {"entities": {"gene": [{"text": "glucan synthase", "start": 10, "end": 25}, {"text": "Rho1p", "start": 58, "end": 63}, {"text": "deltabem4 mutant", "start": 98, "end": 114}]}}, "schema": []}
{"input": "In gel retardation assays, an RCS cell-specific protein and another closely related protein expressed only in RCS cells and primary chondrocytes bound to a 10-bp sequence within the 18-mer.", "output": {"entities": {}}, "schema": []}
{"input": "Two classes of Xanthomonas pathogens evading Bs2 host resistance and displaying reduced fitness were found to be specifically mutated in avrBs2.", "output": {"entities": {"gene": [{"text": "avrBs2", "start": 137, "end": 143}]}}, "schema": []}
{"input": "Thus, the characterization of the promoter region should help to define regulatory elements that control neuron-specific and developmental expression of the MAP1B gene.", "output": {"entities": {"gene": [{"text": "MAP1B gene", "start": 157, "end": 167}]}}, "schema": []}
{"input": "Mutants lacking the 3' stem-loop exhibited a 75% reduction in the level of psaB mRNA.", "output": {"entities": {"gene": [{"text": "psaB", "start": 75, "end": 79}]}}, "schema": []}
{"input": "The deduced amino acid sequence was highly conserved across the wide range of eukaryotes (vertebrates, invertebrates, fungi, plants and protozoa) in which this gene has now been identified.", "output": {"entities": {}}, "schema": []}
{"input": "Semidominant mutations in the yeast Rad51 protein and their relationships with the Srs2 helicase.", "output": {"entities": {"gene": [{"text": "yeast Rad51 protein", "start": 30, "end": 49}, {"text": "Srs2 helicase", "start": 83, "end": 96}]}}, "schema": []}
{"input": "Alterations of the 5q23-q31 interval are frequently observed in myelodysplasia and myeloid leukemia.", "output": {"entities": {}}, "schema": []}
{"input": "Previous studies have suggested that the 616 amino acid, 70-kDa subunit of RPA (RPA 70) is composed of multiple structural/functional domains.", "output": {"entities": {"gene": [{"text": "70-kDa subunit of RPA", "start": 57, "end": 78}, {"text": "RPA 70", "start": 80, "end": 86}]}}, "schema": []}
{"input": "Neurons were held at-67 mV to equate voltage-dependent effects.", "output": {"entities": {}}, "schema": []}
{"input": "This site acts as a negative element when transferred to the thymidine kinase promoter, but does not confer inducibility.", "output": {"entities": {"gene": [{"text": "thymidine kinase promoter", "start": 61, "end": 86}]}}, "schema": []}
{"input": "The extent of the fbpA operator sequence (42 bp), as defined by our footprinting analysis, would suggest the binding of two Fur repressor dimers.", "output": {"entities": {"gene": [{"text": "fbpA operator sequence (42 bp)", "start": 18, "end": 48}, {"text": "Fur repressor dimers", "start": 124, "end": 144}]}}, "schema": []}
{"input": "The structural similarity between Vav and other guanine nucleotide exchange factors for small GTP-binding proteins, together with the recent identification of biochemical routes specific for members of the Ras and Rho family of GTPases, prompted us to explore whether MAPK or JNK are downstream components of the Vav signaling pathways.", "output": {"entities": {"gene": [{"text": "Vav", "start": 34, "end": 37}, {"text": "guanine nucleotide exchange factors", "start": 48, "end": 83}, {"text": "small GTP-binding proteins", "start": 88, "end": 114}, {"text": "Ras", "start": 206, "end": 209}, {"text": "Rho family", "start": 214, "end": 224}, {"text": "GTPases", "start": 228, "end": 235}, {"text": "MAPK", "start": 268, "end": 272}, {"text": "JNK", "start": 276, "end": 279}, {"text": "Vav", "start": 313, "end": 316}]}}, "schema": []}
{"input": "CONCLUSION: Twice daily treatment with inhaled fluticasone propionate 50 micrograms or 100 micrograms was significantly more effective than theophylline in the treatment of mild-to-moderate asthma.", "output": {"entities": {}}, "schema": []}
{"input": "Our results support a model where both E2F-and CDE-mediated repression, acting at different stages in the cell cycle, are dependent on promoter-specific CHR elements.", "output": {"entities": {"gene": [{"text": "E2F", "start": 39, "end": 42}]}}, "schema": []}
{"input": "The cDNA clone was used as a homologous probe to isolate a truncated genomic clone encoding H2A1.", "output": {"entities": {"gene": [{"text": "H2A1", "start": 92, "end": 96}]}}, "schema": []}
{"input": "Comparison of the deduced amino acid sequences with protein sequences of T. pyriformis H2As showed only two and three differences respectively, in a total of 137 amino acids for H2A1, and 132 amino acids for H2A2, indicating the two genes arose before the divergence of these two species.", "output": {"entities": {"gene": [{"text": "H2As", "start": 87, "end": 91}, {"text": "H2A1", "start": 178, "end": 182}, {"text": "H2A2", "start": 208, "end": 212}]}}, "schema": []}
{"input": "Cognitive visual dysfunction in a child with cerebral damage.", "output": {"entities": {}}, "schema": []}
{"input": "Interaction was apparently determined by the N-terminal splice region of RPDE-6, as the PDE4A splice variant RPDE-39, which differs from RPDE-6 at the extreme N-terminus, failed to associate with v-Src-SH3; met26RD1 (where RD1 is rat' dunc-like' PDE), which has the N-terminal splice region deleted, failed to associate with v-Src-SH3, and the association of RPDE-6 and v-Src-SH3 was blocked by a fusion protein formed from the N-terminal splice region.", "output": {"entities": {"gene": [{"text": "RPDE-6", "start": 73, "end": 79}, {"text": "PDE4A", "start": 88, "end": 93}, {"text": "RPDE-39", "start": 109, "end": 116}, {"text": "RPDE-6", "start": 137, "end": 143}, {"text": "v-Src", "start": 196, "end": 201}, {"text": "SH3", "start": 202, "end": 205}, {"text": "met26RD1", "start": 207, "end": 215}, {"text": "RD1", "start": 223, "end": 226}, {"text": "rat' dunc-like' PDE", "start": 230, "end": 249}, {"text": "v-Src", "start": 325, "end": 330}, {"text": "SH3", "start": 331, "end": 334}, {"text": "RPDE-6", "start": 359, "end": 365}, {"text": "v-Src", "start": 370, "end": 375}, {"text": "SH3", "start": 376, "end": 379}]}}, "schema": []}
{"input": "Potentially load-insensitive measures of ventricular performance were therefore evaluated in 10 open-and closed-chested, anesthetized rabbits.", "output": {"entities": {}}, "schema": []}
{"input": "Large strain differences were found for all variables recorded, i. e., the proportion of attacking males, the time spent in the brightly lit box, and the number of transitions between the lit and the dark boxes.", "output": {"entities": {}}, "schema": []}
{"input": "It is the oxidation peak of this product, arising in acidic media at 0. 42 V, which was analysed using DPV, again following the accumulation of clenbuterol at the Nafion-modified CPE.", "output": {"entities": {}}, "schema": []}
{"input": "Phenylephrine is a pure alpha-1 adrenoreceptor agonist known to produce marked systemic vasoconstriction and associated hypertension with occasional profound reflex bradycardia.", "output": {"entities": {"gene": [{"text": "alpha-1 adrenoreceptor", "start": 24, "end": 46}]}}, "schema": []}
{"input": "The expression of the first two genes located in this unit (c-gvpD and c-gvpE) was also monitored by Western blot (immunoblot) analyses using antisera raised against these proteins synthesized in Escherichia coli.", "output": {"entities": {"gene": [{"text": "c-gvpD", "start": 60, "end": 66}, {"text": "c-gvpE", "start": 71, "end": 77}]}}, "schema": []}
{"input": "One unit encodes traA, traF, and traB, while the second encodes traC, traD, and traG.", "output": {"entities": {"gene": [{"text": "traA", "start": 17, "end": 21}, {"text": "traF", "start": 23, "end": 27}, {"text": "traB", "start": 33, "end": 37}, {"text": "traC", "start": 64, "end": 68}, {"text": "traD", "start": 70, "end": 74}, {"text": "traG", "start": 80, "end": 84}]}}, "schema": []}
{"input": "A.", "output": {"entities": {}}, "schema": []}
{"input": "In an effort to isolate genes with down-regulated expression at the mRNA level during oncogenic transformation of human mammary epithelial cells (MECs), we performed subtractive hybridization between normal MEC strain 76N and its radiation-transformed tumorigenic derivative 76R-30.", "output": {"entities": {}}, "schema": []}
{"input": "CASE REPORT: Referred because of a right corneal perforation with cellular reaction in anterior chamber, a patient was sutured and treated with a single intravitreal injection of 0. 2 ml (1 mg) Amikacin and 0. 2 ml (1 mg) Vancomycin.", "output": {"entities": {}}, "schema": []}
{"input": "The P-wr and P-rr cDNA sequences are very similar in their 5' regions.", "output": {"entities": {"gene": [{"text": "P-wr", "start": 4, "end": 8}, {"text": "P-rr cDNA sequences", "start": 13, "end": 32}]}}, "schema": []}
{"input": "Because the hcf109 locus was mapped at a distance < 0. 1 centimorgans from the phytochrome C gene, its molecular characterization by positional cloning is possible.", "output": {"entities": {"gene": [{"text": "hcf109 locus", "start": 12, "end": 24}, {"text": "phytochrome C gene", "start": 79, "end": 97}]}}, "schema": []}
{"input": "The human MSH-2 gene product is a member of a highly conserved family of proteins which are involved in post-replication mismatch repair. hMSH-2 is homologous to Escherichia coli (E. coli) MutS and Sacchromyces cerevisiae MSH-1 and MSH-2 proteins, which recognise heteroduplex DNA at the sites of all single base mismatches and deletions or insertions up to 4 base pairs. hMSH-2 is one of the hereditary non-polyposis colorectal cancer (HNPCC) tumor suppressor genes, and maps to human chromosome 2p16.", "output": {"entities": {"gene": [{"text": "human MSH-2 gene product", "start": 4, "end": 28}, {"text": "hMSH-2", "start": 138, "end": 144}, {"text": "MutS", "start": 189, "end": 193}, {"text": "Sacchromyces cerevisiae MSH-1", "start": 198, "end": 227}, {"text": "MSH-2 proteins", "start": 232, "end": 246}, {"text": "hMSH-2", "start": 372, "end": 378}, {"text": "hereditary non-polyposis colorectal cancer (HNPCC) tumor suppressor genes", "start": 393, "end": 466}]}}, "schema": []}
{"input": "We have recently shown that the tissue-specific expression of the RAR beta 2 gene in mouse embryos is regulated at the translational level by short upstream open reading frames (uORFs) In the 5'-untranslated region (Zimmer, A., A. M.", "output": {"entities": {"gene": [{"text": "RAR beta 2 gene in mouse embryos", "start": 66, "end": 98}]}}, "schema": []}
{"input": "We have previously isolated a cDNA for a transcription factor referred to as Zfhep (zinc finger homeodomain enhancer-binding protein) containing two separate zinc finger domains, ZD1 and ZD2, each of which binds DNA, and a homeodomain.", "output": {"entities": {"gene": [{"text": "Zfhep", "start": 77, "end": 82}, {"text": "zinc finger homeodomain enhancer-binding protein", "start": 84, "end": 132}, {"text": "ZD1", "start": 179, "end": 182}, {"text": "ZD2", "start": 187, "end": 190}]}}, "schema": []}
{"input": "Increased PTHRP production by a tyrosine kinase oncogene, Tpr-Met: role of the Ras signaling pathway.", "output": {"entities": {"gene": [{"text": "PTHRP", "start": 10, "end": 15}, {"text": "tyrosine kinase oncogene", "start": 32, "end": 56}, {"text": "Tpr-Met", "start": 58, "end": 65}, {"text": "Ras", "start": 79, "end": 82}]}}, "schema": []}
{"input": "Subsequent to their secretion, the IGF-II in xz97 and G11 cells accumulated in the conditioned medium mostly as two partially processed species with appMr, of 17K and 14K, respectively.", "output": {"entities": {"gene": [{"text": "IGF-II", "start": 35, "end": 41}]}}, "schema": []}
{"input": "Paradoxically, coexpression of the transcriptionally inactive, amino-terminally deleted IDX-1 mutant proteins, either with the wild-type IDX-1 or with themselves, results in a marked enhancement of transactivation of the transcriptional TAAT-1 element reporter.", "output": {"entities": {"gene": [{"text": "IDX-1 mutant proteins", "start": 88, "end": 109}, {"text": "wild-type IDX-1", "start": 127, "end": 142}, {"text": "TAAT-1 element reporter", "start": 237, "end": 260}]}}, "schema": []}
{"input": "All patients had abnormal von Willebrand factor (vWF) fragmentation as reflected by decreased high molecular weight and increased low molecular weight vWF multimers in the circulation.", "output": {"entities": {"gene": [{"text": "von Willebrand factor", "start": 26, "end": 47}, {"text": "vWF", "start": 49, "end": 52}, {"text": "vWF multimers", "start": 151, "end": 164}]}}, "schema": []}
{"input": "In an attempt to investigate whether the intergenic region between the oleosin and a second open reading frame (ORFII) in Brassica napus (L.) is a divergent promoter, and also to characterize the ORFII, cDNA clones homologous to ORFII were isolated from a leaf cDNA library.", "output": {"entities": {"gene": [{"text": "oleosin", "start": 71, "end": 78}, {"text": "ORFII", "start": 112, "end": 117}, {"text": "cDNA clones homologous to ORFII", "start": 203, "end": 234}]}}, "schema": []}
{"input": "The ORFII gene product is targeted to the chloroplast, which is consistent with previous data indicating the presence of PMSR activity in the chloroplast.", "output": {"entities": {"gene": [{"text": "ORFII gene product", "start": 4, "end": 22}, {"text": "PMSR", "start": 121, "end": 125}]}}, "schema": []}
{"input": "Characterization of LRP, a leucine-rich repeat (LRR) protein from tomato plants that is processed during pathogenesis.", "output": {"entities": {"gene": [{"text": "LRP", "start": 20, "end": 23}, {"text": "leucine-rich repeat (LRR) protein from tomato plants", "start": 27, "end": 79}]}}, "schema": []}
{"input": "To test whether Sp1 and zif268/egr-1 interact with this motif, gel retardation assays were performed.", "output": {"entities": {"gene": [{"text": "Sp1", "start": 16, "end": 19}, {"text": "zif268", "start": 24, "end": 30}, {"text": "egr-1", "start": 31, "end": 36}]}}, "schema": []}
{"input": "OBJECTIVES: The aim of the study was to analyze the clinical characteristics, treatment and outcome of 310 patients with hydatidiform mole.", "output": {"entities": {}}, "schema": []}
{"input": "Stably transfected human kidney 293 cells expressing the wild type rat LH/CG receptor (rLHR) or receptors with C-terminal tails truncated at residues 653, 631, or 628 (designated rLHR-t653, rLHR-t631, and rLHR-t628) were used to probe the importance of this region on the regulation of hormonal responsiveness.", "output": {"entities": {"gene": [{"text": "wild type rat LH/CG receptor", "start": 57, "end": 85}, {"text": "rLHR", "start": 87, "end": 91}, {"text": "rLHR-t653", "start": 179, "end": 188}, {"text": "rLHR-t631", "start": 190, "end": 199}, {"text": "rLHR-t628", "start": 205, "end": 214}]}}, "schema": []}
{"input": "Are low P300 amplitudes a marker for schizophrenia.", "output": {"entities": {}}, "schema": []}
{"input": "Sleep was determined again for an additional 3 days and 6 hours.", "output": {"entities": {}}, "schema": []}
{"input": "The patients are two healthy adult males.", "output": {"entities": {}}, "schema": []}
{"input": "Indoor concentrations were only weakly correlated with outdoor concentrations, however, and personal exposures were even more poorly correlated with outdoor concentrations.", "output": {"entities": {}}, "schema": []}
{"input": "A neuropsychological test battery was used that contained the Wisconsin card sorting test, Street completion test, Stroop test, a dichotic memory listening test, and a facial recognition test.", "output": {"entities": {}}, "schema": []}
{"input": "We present this case because of the rarity of left ventricular involvement associated with ARVD.", "output": {"entities": {}}, "schema": []}
{"input": "In a randomized single-blind 3 x 3 Latin-square study with corrections for any carryover effects, 27 males and 30 females consumed supplements containing glucose or resistant starch (RS) from raw high-amylose cornstarch (RS2) or from retrograded high-amylose cornstarch (RS3).", "output": {"entities": {}}, "schema": []}
{"input": "The 5' flanking region of the mouse Met-ase-1 gene also shares considerable regions of identity with the 5' flanking region of the rat Met-ase-1 gene.", "output": {"entities": {"gene": [{"text": "mouse Met-ase-1 gene", "start": 30, "end": 50}, {"text": "rat Met-ase-1 gene", "start": 131, "end": 149}]}}, "schema": []}
{"input": "The [18F] FMISO TMRR is a simple and clinically useful index for detecting tumour hypoxia in NPC.", "output": {"entities": {}}, "schema": []}
{"input": "Improved methods have been developed for maintaining and breeding the neotropical short-tailed fruit bat, Carollia perspicillata, in an easily-reproduced, laboratory setting.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, the time to engraftment was significantly shorter in the amifostine arm in both cohorts.", "output": {"entities": {}}, "schema": []}
{"input": "We conclude that CPET is a useful investigation in the management of patients with cardiopulmonary disease and complements the various other investigations offered by a pulmonary function laboratory.", "output": {"entities": {}}, "schema": []}
{"input": "Using fluorescence in situ hybridization, we mapped the chromosome-17 breakpoint in a patient with acampomelic CMPD and sex reversal, who carries a de novo constitutional t (12; 17) translocation, between two known cosmid markers in the 17q24-q25 region.", "output": {"entities": {}}, "schema": []}
{"input": "This is concluded from the isolation of cDNAs from spinach (Spinacia oleracea) and barley (Hordeum vulgare cv.", "output": {"entities": {}}, "schema": []}
{"input": "The data presented in this work indicate that thi1 may also be involved in DNA damage tolerance in plant cells.", "output": {"entities": {"gene": [{"text": "thi1", "start": 46, "end": 50}]}}, "schema": []}
{"input": "In the rat rnu allele described here, a nonsense mutation in exon 8 of the whn gene was identified.", "output": {"entities": {"gene": [{"text": "rat rnu allele", "start": 7, "end": 21}, {"text": "whn gene", "start": 75, "end": 83}]}}, "schema": []}
{"input": "Control intact rats were age-matched to the different treated groups.", "output": {"entities": {}}, "schema": []}
{"input": "DESIGN: A cross-sectional study.", "output": {"entities": {}}, "schema": []}
{"input": "We have identified a strong Tas-responsive element, designated TRE (GP), near the 3' end of the gag gene and preceding the pol gene of SFV-1.", "output": {"entities": {"gene": [{"text": "Tas-responsive element", "start": 28, "end": 50}, {"text": "TRE", "start": 63, "end": 66}, {"text": "GP", "start": 68, "end": 70}, {"text": "gag gene", "start": 96, "end": 104}, {"text": "pol gene", "start": 123, "end": 131}]}}, "schema": []}
{"input": "Although the binding of IE2 86 to nonphosphorylated full-length CREB or deltaCREB is minimal, IE2 86 does form complexes with p300 and the CREB-binding protein (CBP), which in turn bind to CREB and can serve as adaptor proteins for CREB function.", "output": {"entities": {"gene": [{"text": "IE2 86", "start": 24, "end": 30}, {"text": "full-length CREB", "start": 52, "end": 68}, {"text": "deltaCREB", "start": 72, "end": 81}, {"text": "IE2 86", "start": 94, "end": 100}, {"text": "p300", "start": 126, "end": 130}, {"text": "CREB-binding protein", "start": 139, "end": 159}, {"text": "CBP", "start": 161, "end": 164}, {"text": "CREB", "start": 189, "end": 193}, {"text": "CREB", "start": 232, "end": 236}]}}, "schema": []}
{"input": "A transgenic complementation assay was used to test whether NIa supplied in trans could rescue amplification-defective viral genomes encoding altered NIa proteins.", "output": {"entities": {"gene": [{"text": "NIa", "start": 60, "end": 63}, {"text": "NIa proteins", "start": 150, "end": 162}]}}, "schema": []}
{"input": "On the basis of its bZIP structural homology, meq is perhaps the only member of the jun-fos gene family completely viral in origin.", "output": {"entities": {"gene": [{"text": "meq", "start": 46, "end": 49}, {"text": "jun", "start": 84, "end": 87}, {"text": "fos", "start": 88, "end": 91}]}}, "schema": []}
{"input": "The rCBF and vasomotion were recorded by laser-doppler fluxmetry.", "output": {"entities": {}}, "schema": []}
{"input": "Although basal vessels may constrict distal parenchymal vessels tend to dilate after SAH.", "output": {"entities": {}}, "schema": []}
{"input": "The triple combination of nizatidine, clarithromycin, and bismuth subcitrate resulted in an ulcer healing rate of 98% and an H. pylori eradication rate of 90%.", "output": {"entities": {}}, "schema": []}
{"input": "Several lines of evidence presented here suggest that PKC-zeta plays a role in alpha 2 integrin gene expression.", "output": {"entities": {"gene": [{"text": "PKC-zeta", "start": 54, "end": 62}, {"text": "alpha 2 integrin gene", "start": 79, "end": 100}]}}, "schema": []}
{"input": "Plasma thrombomodulin: a marker for microvascular complications in diabetes mellitus.", "output": {"entities": {"gene": [{"text": "thrombomodulin", "start": 7, "end": 21}]}}, "schema": []}
{"input": "Update: diphtheria epidemic in the newly independent states of the former USSR, January 1995-March 1996.", "output": {"entities": {}}, "schema": []}
{"input": "The characterization of the promoter region indicated that three distinct regulatory elements corresponding to an AP-1 binding site (or TRE), a PRDII/kappaB domain, and a CAAT box are involved in the activation by pp60 (v-) src.", "output": {"entities": {"gene": [{"text": "AP-1 binding site", "start": 114, "end": 131}, {"text": "PRDII", "start": 144, "end": 149}, {"text": "kappaB", "start": 150, "end": 156}, {"text": "pp60 (v-) src", "start": 214, "end": 227}]}}, "schema": []}
{"input": "Serine 528 is phosphorylated in vivo in several cell lines, and substitution of serine 528 to alanine (S528A) resulted in an increased ability of Myb to transactivate a synthetic promoter containing five copies of the mim-1A Myb-responsive element and a minimal herpes tk promoter.", "output": {"entities": {"gene": [{"text": "Myb", "start": 146, "end": 149}, {"text": "mim-1A Myb", "start": 218, "end": 228}, {"text": "herpes tk promoter", "start": 262, "end": 280}]}}, "schema": []}
{"input": "The DNA binding and multimerization activities of c-Myb appear to be unaffected by the S528A substitution, suggesting that phosphorylation of serine 528 may mediate its effect on the transcription transactivating activity of c-Myb by regulating interactions with other proteins.", "output": {"entities": {"gene": [{"text": "c-Myb", "start": 50, "end": 55}, {"text": "c-Myb", "start": 225, "end": 230}]}}, "schema": []}
{"input": "The amount of these factors was reduced in GEO cells in which the u-PAR gene is only weakly transcriptionally activated.", "output": {"entities": {"gene": [{"text": "u-PAR gene", "start": 66, "end": 76}]}}, "schema": []}
{"input": "PIP2, when incorporated into phosphatidylcholine carrier vesicles, binds tightly to the guanine nucleotide-depleted form of Cdc42Hs and weakly to the GDP-bound form of the GTP-binding protein but does not bind to GTP-bound Cdc42Hs, similar to what was observed for the Dbl oncoprotein.", "output": {"entities": {"gene": [{"text": "Cdc42Hs", "start": 124, "end": 131}, {"text": "GTP-binding protein", "start": 172, "end": 191}, {"text": "Cdc42Hs", "start": 223, "end": 230}, {"text": "Dbl oncoprotein", "start": 269, "end": 284}]}}, "schema": []}
{"input": "Purified spleen GAP accelerated hydrolysis of GTP bound to recombinant ARF1, ARF3, ARF5, and ARF6; no effect of NH2-terminal myristoylation was observed.", "output": {"entities": {"gene": [{"text": "GAP", "start": 16, "end": 19}, {"text": "recombinant ARF1", "start": 59, "end": 75}, {"text": "ARF3", "start": 77, "end": 81}, {"text": "ARF5", "start": 83, "end": 87}, {"text": "ARF6", "start": 93, "end": 97}]}}, "schema": []}
{"input": "Biol.", "output": {"entities": {}}, "schema": []}
{"input": "A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells.", "output": {"entities": {"gene": [{"text": "Cbl", "start": 80, "end": 83}, {"text": "ZAP-70", "start": 124, "end": 130}]}}, "schema": []}
{"input": "Cys-757 within the (Fe4S4)-siroheme-binding domain was essential for native enzyme activity.", "output": {"entities": {}}, "schema": []}
{"input": "Its transcription has been shown to be induced 40-50-fold in response to oxygen or heme deficiency, in part through relief of repression exerted by Rox1p and in part by activation mediated by an upstream activation sequence (UAS).", "output": {"entities": {"gene": [{"text": "Rox1p", "start": 148, "end": 153}]}}, "schema": []}
{"input": "Altogether, our results indicate that the transcriptional activity of Cut proteins is modulated by PKC.", "output": {"entities": {"gene": [{"text": "Cut proteins", "start": 70, "end": 82}, {"text": "PKC", "start": 99, "end": 102}]}}, "schema": []}
{"input": "Lck has been postulated to dimerize through the SH2 and SH3 domains.", "output": {"entities": {"gene": [{"text": "Lck", "start": 0, "end": 3}, {"text": "SH2", "start": 48, "end": 51}, {"text": "SH3 domains", "start": 56, "end": 67}]}}, "schema": []}
{"input": "Furthermore, freezing in the presence of bovine lactalbumin resulted in a good maintenance of the cellular viability and of the CCCD heterogeneity in respect to fresh cells.", "output": {"entities": {"gene": [{"text": "bovine lactalbumin", "start": 41, "end": 59}]}}, "schema": []}
{"input": "Myelomatous pleural effusion as presentation form of multiple myeloma", "output": {"entities": {}}, "schema": []}
{"input": "The presence of unidentified macroscopic or microscopic clusters of neoplastic cells, lying around, more or less close to, the line of insertion of lesion, could render any attempt to gain a \" radical \" excision useless.", "output": {"entities": {}}, "schema": []}
{"input": "The partial categories of the SIP that were more affected were work, recreation and pastimes, home management, and sleep and rest.", "output": {"entities": {}}, "schema": []}
{"input": "Northern blot analysis, using the Ltp4-specific probe, indicated that Xanthomonas campestris pv. translucens induced an increase over basal levels of Ltp4 mRNA, while Pseudomonas syringae pv. japonica caused a decrease.", "output": {"entities": {"gene": [{"text": "Ltp4", "start": 34, "end": 38}, {"text": "Ltp4 mRNA", "start": 150, "end": 159}]}}, "schema": []}
{"input": "Furthermore, the use of zero-loss filtering in combination with exit wavefront reconstruction is considerably more effective at removing the effects of multiple elastic and inelastic scattering and microscope objective lens aberrations than either technique by itself.", "output": {"entities": {}}, "schema": []}
{"input": "Transcripts for both ODV-E18 and ODV-EC27 initiate from conserved TAAG motifs, and transcripts are detected from 16 through 72 hr p. i.", "output": {"entities": {"gene": [{"text": "ODV-E18", "start": 21, "end": 28}, {"text": "ODV-EC27", "start": 33, "end": 41}]}}, "schema": []}
{"input": "In order to determine which sequences in the GATA-1 promoter are crucial for activation by the ME26 viral protein, we made deletions of the promoter, cloned them into a luciferase expression vector and tested their activity in mouse fibroblasts, which do not express GATA-1.", "output": {"entities": {"gene": [{"text": "GATA-1 promoter", "start": 45, "end": 60}, {"text": "ME26 viral protein", "start": 95, "end": 113}, {"text": "luciferase", "start": 169, "end": 179}, {"text": "GATA-1", "start": 267, "end": 273}]}}, "schema": []}
{"input": "A 3-yr retrospective review is effective and detects 94% of the undercalls.", "output": {"entities": {}}, "schema": []}
{"input": "Isolation and identification of genes activating UAS2-dependent ADH2 expression in Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "UAS2-dependent ADH2", "start": 49, "end": 68}]}}, "schema": []}
{"input": "METHODS AND RESULTS: A 64-year-old woman with confirmed AV nodal reentrant tachycardia underwent a successful \" slow pathway \" AV modification with a single radiofrequency application.", "output": {"entities": {}}, "schema": []}
{"input": "Patients with low probability of having aluminum overload (serum iron levels < 40 micrograms/L and DAI < 150 micrograms/L) had significantly higher values of serum iron, iron transferrin saturation, and serum ferritin levels compared with those patients with a high probability of having aluminum overload (serum aluminum levels > 40 micrograms/L and DAI > 150 micrograms/L).", "output": {"entities": {"gene": [{"text": "transferrin", "start": 175, "end": 186}, {"text": "serum ferritin", "start": 203, "end": 217}]}}, "schema": []}
{"input": "Although the RAD23 equivalents are well conserved during evolution, the mammalian genes did not express the UV-inducible phenotype of their yeast counterpart.", "output": {"entities": {"gene": [{"text": "RAD23", "start": 13, "end": 18}]}}, "schema": []}
{"input": "Ha-RasV12 and activated proteins in both the extra-cellular regulated kinase (ERK) and the stress-activated protein kinase (SAPK) or Jun N-terminal kinase (JNK) cascades independently stimulated PEA3-mediated gene expression.", "output": {"entities": {"gene": [{"text": "Ha-RasV12", "start": 0, "end": 9}, {"text": "extra-cellular regulated kinase", "start": 45, "end": 76}, {"text": "ERK", "start": 78, "end": 81}, {"text": "stress-activated protein kinase", "start": 91, "end": 122}, {"text": "SAPK", "start": 124, "end": 128}, {"text": "Jun N-terminal kinase", "start": 133, "end": 154}, {"text": "JNK", "start": 156, "end": 159}, {"text": "PEA3", "start": 195, "end": 199}]}}, "schema": []}
{"input": "Sequence analysis of reverse transcribed, amplified cDNA generated from total RNA isolated from transfected cells demonstrated the presence of abnormally spliced products containing 13 and 78 additional bases as well as the accumulation of unspliced mRNA.", "output": {"entities": {}}, "schema": []}
{"input": "A 1. 5-kb HindIII genomic fragment carrying the vspA gene from M. bovis PG45 was cloned and sequenced.", "output": {"entities": {"gene": [{"text": "HindIII", "start": 10, "end": 17}, {"text": "vspA", "start": 48, "end": 52}]}}, "schema": []}
{"input": "Carbon catabolite repression of the gnt operon of Bacillus subtilis is mediated by the catabolite control protein CcpA and by HPr, a phosphocarrier protein of the phosphotransferase system.", "output": {"entities": {"gene": [{"text": "gnt operon of Bacillus subtilis", "start": 36, "end": 67}, {"text": "CcpA", "start": 114, "end": 118}, {"text": "HPr", "start": 126, "end": 129}]}}, "schema": []}
{"input": "Melatonin and seasonality: filling the gap.", "output": {"entities": {}}, "schema": []}
{"input": "A subsequent screen for the loss of the positively selectable target locus marker detects the desired replacement at modest frequency (> 2%).", "output": {"entities": {}}, "schema": []}
{"input": "Here we demonstrate that another cellular protein linked to BCR/ABL through the CRKL-SH2 domain is p130 (CAS). p130 (CAS) was found to be tyrosine phosphorylated and associated with CRKL in BCR/ABL expressing cell lines and in samples obtained from CML and ALL patients, but not in samples from controls.", "output": {"entities": {"gene": [{"text": "BCR", "start": 60, "end": 63}, {"text": "ABL", "start": 64, "end": 67}, {"text": "CRKL", "start": 80, "end": 84}, {"text": "SH2", "start": 85, "end": 88}, {"text": "p130", "start": 99, "end": 103}, {"text": "CAS", "start": 105, "end": 108}, {"text": "p130", "start": 111, "end": 115}, {"text": "CAS", "start": 117, "end": 120}, {"text": "CRKL", "start": 182, "end": 186}, {"text": "BCR", "start": 190, "end": 193}, {"text": "ABL", "start": 194, "end": 197}]}}, "schema": []}
{"input": "The effects of procedural variations on lateralized Stroop effects.", "output": {"entities": {}}, "schema": []}
{"input": "In a third experiment, a Chessmaster gradually increases the number of boards he can reproduce with higher than 70% average accuracy to nine, replacing as many as 160 pieces correctly.", "output": {"entities": {}}, "schema": []}
{"input": "PCNA mRNA has a 3' UTR antisense to yellow crescent RNA and is localized in ascidian eggs and embryos.", "output": {"entities": {"gene": [{"text": "PCNA mRNA", "start": 0, "end": 9}]}}, "schema": []}
{"input": "A 1. 8-kb cDNA clone (designed hKID, gene symbol AQP2L) with homology to the aquaporins was isolated from a human kidney cDNA library.", "output": {"entities": {"gene": [{"text": "hKID", "start": 31, "end": 35}, {"text": "gene symbol AQP2L", "start": 37, "end": 54}, {"text": "aquaporins", "start": 77, "end": 87}]}}, "schema": []}
{"input": "PCR/Southern blot analysis of human kidney cDNA using primers flanking the hKID coding sequence revealed expression of a full-length mRNA and short transcripts with partial exon 1 and partial exon 4 deletions.", "output": {"entities": {"gene": [{"text": "hKID coding sequence", "start": 75, "end": 95}]}}, "schema": []}
{"input": "The high sequence homology, similar genomic structure, and identical chromosomal loci of hKID, MIP, and AQP-2 suggest a MIP family gene cluster at chromosome locus 12q13.", "output": {"entities": {"gene": [{"text": "hKID", "start": 89, "end": 93}, {"text": "MIP", "start": 95, "end": 98}, {"text": "AQP-2", "start": 104, "end": 109}, {"text": "MIP family gene cluster", "start": 120, "end": 143}]}}, "schema": []}
{"input": "The third ORF generates a transcript of 1. 6 kb and encodes a protein of 382 residues including a perfect match to the consensus sequence of a C2H2 zinc finger domain; it shares a strong homology with yeast Mig1p and Cre-A from Aspergillus, Emericella and E. coli.", "output": {"entities": {"gene": [{"text": "yeast Mig1p", "start": 201, "end": 212}, {"text": "Cre-A from Aspergillus, Emericella and E. coli", "start": 217, "end": 263}]}}, "schema": []}
{"input": "Adding phytase and nP improved the orderliness of development, mineralization and arrangement of cartilage and bone cells, and alleviated the effects of P deficiency on the histological and gross structure of the tibias.", "output": {"entities": {"gene": [{"text": "phytase", "start": 7, "end": 14}]}}, "schema": []}
{"input": "The importance of temporal factors on the presence and severity of ethanol withdrawal signs in the rat was quantified using rating scale, tremor, and acoustic startle paradigms.", "output": {"entities": {}}, "schema": []}
{"input": "Data supported the brevity of the WISC-III short form and the criterion-related validity of both the K-FAST and and Kaufman Short Neuropsychological Assessment Procedure (K-SNAP).", "output": {"entities": {}}, "schema": []}
{"input": "Thus, the multidomained ROK alpha appears to be involved in reorganization of the cytoskeleton, with the N and C termini acting as positive and negative regulators, respectively, of the kinase domain whose activity is crucial for formation of stress fibers and focal adhesion complexes.", "output": {"entities": {"gene": [{"text": "ROK alpha", "start": 24, "end": 33}]}}, "schema": []}
{"input": "These findings and the differential tissue distribution of p54 suggest that this novel SR protein may participate in regulation of alternative splicing in a tissue-and substrate-dependent manner.", "output": {"entities": {"gene": [{"text": "p54", "start": 59, "end": 62}, {"text": "SR protein", "start": 87, "end": 97}]}}, "schema": []}
{"input": "The elevation of cyclic AMP (cAMP) levels in the cell downregulates the activity of the Raf-1 kinase.", "output": {"entities": {"gene": [{"text": "Raf-1 kinase", "start": 88, "end": 100}]}}, "schema": []}
{"input": "An interaction screen with the repression domain of the orphan receptor RevErb identified N-CoR, the corepressor for thyroid hormone receptor (TR) and retinoic acid receptor (RAR).", "output": {"entities": {"gene": [{"text": "orphan receptor RevErb", "start": 56, "end": 78}, {"text": "N-CoR", "start": 90, "end": 95}, {"text": "thyroid hormone receptor", "start": 117, "end": 141}, {"text": "TR", "start": 143, "end": 145}, {"text": "retinoic acid receptor", "start": 151, "end": 173}, {"text": "RAR", "start": 175, "end": 178}]}}, "schema": []}
{"input": "These results indicate that inhibition of Jun kinase activation was sufficient to inhibit Ras transformation even in the presence of activated Erk-2.", "output": {"entities": {"gene": [{"text": "Jun kinase", "start": 42, "end": 52}, {"text": "Ras", "start": 90, "end": 93}, {"text": "Erk-2", "start": 143, "end": 148}]}}, "schema": []}
{"input": "Our analysis suggests that Upf1p is a multifunctional protein with separable activities that can affect mRNA turnover and nonsense suppression.", "output": {"entities": {"gene": [{"text": "Upf1p", "start": 27, "end": 32}]}}, "schema": []}
{"input": "Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe.", "output": {"entities": {"gene": [{"text": "Ste4", "start": 18, "end": 22}, {"text": "Byr2", "start": 51, "end": 55}]}}, "schema": []}
{"input": "Two closely related variants of Stat5, Stat5a and Stat5b, are encoded by distinct genes.", "output": {"entities": {"gene": [{"text": "Stat5", "start": 32, "end": 37}, {"text": "Stat5a", "start": 39, "end": 45}, {"text": "Stat5b", "start": 50, "end": 56}]}}, "schema": []}
{"input": "Mutations in three loci (SIC1, SWI5, and RIC3) were identified.", "output": {"entities": {"gene": [{"text": "SIC1", "start": 25, "end": 29}, {"text": "SWI5", "start": 31, "end": 35}, {"text": "RIC3", "start": 41, "end": 45}]}}, "schema": []}
{"input": "The serine/threonine kinase Raf-1 functions downstream of Rats in a signal transduction cascade which transmits mitogenic stimuli from the plasma membrane to the nucleus.", "output": {"entities": {"gene": [{"text": "serine/threonine kinase Raf-1", "start": 4, "end": 33}, {"text": "Rats", "start": 58, "end": 62}]}}, "schema": []}
{"input": "In transient cotransfections E1A could induce the activity of the p53 promoter to a high level; 12S E1A was threefold as efficient as 13S E1A in this activity, and YY1 bound to the composite element was shown to mediate 55% of this induction.", "output": {"entities": {"gene": [{"text": "E1A", "start": 29, "end": 32}, {"text": "p53 promoter", "start": 66, "end": 78}, {"text": "12S E1A", "start": 96, "end": 103}, {"text": "13S E1A", "start": 134, "end": 141}, {"text": "YY1", "start": 164, "end": 167}]}}, "schema": []}
{"input": "The retinoid Z receptor beta (RZR beta), an orphan receptor, is a member of the retinoic acid receptor (RAR)/thyroid hormone receptor (TR) subfamily of nuclear receptors.", "output": {"entities": {"gene": [{"text": "retinoid Z receptor beta", "start": 4, "end": 28}, {"text": "RZR beta", "start": 30, "end": 38}, {"text": "retinoic acid receptor", "start": 80, "end": 102}, {"text": "RAR", "start": 104, "end": 107}, {"text": "thyroid hormone receptor", "start": 109, "end": 133}, {"text": "TR", "start": 135, "end": 137}]}}, "schema": []}
{"input": "DNA-dependent protein kinase (DNA-PK) consists of a heterodimeric protein (Ku) and a large catalytic subunit (DNA-PKcs).", "output": {"entities": {"gene": [{"text": "DNA-dependent protein kinase", "start": 0, "end": 28}, {"text": "DNA-PK", "start": 30, "end": 36}, {"text": "Ku", "start": 75, "end": 77}, {"text": "DNA-PKcs", "start": 110, "end": 118}]}}, "schema": []}
{"input": "Sequencing of the 16p 11. 1/Xq28 duplication breakpoints has revealed the presence of repetitive immunoglobulin-like CAGGG pentamer sequences at or near the paralogy boundaries.", "output": {"entities": {"gene": [{"text": "immunoglobulin-like CAGGG pentamer sequences", "start": 97, "end": 141}]}}, "schema": []}
{"input": "However, in a multivariate analysis considering age, gender, and a previous history of cardiovascular diseases, female gender was not independently associated with death.", "output": {"entities": {}}, "schema": []}
{"input": "Moreover, following a single intravenous injection of the bicistronic vector complexed to cationic liposomes into recipient mice, delivery of MDR1 and GC cDNAs was achieved in all the organs we tested.", "output": {"entities": {"gene": [{"text": "MDR1", "start": 142, "end": 146}, {"text": "GC cDNAs", "start": 151, "end": 159}]}}, "schema": []}
{"input": "The limits of agreement between DBS and TOF responses were so wide that they cannot be used interchangeably.", "output": {"entities": {}}, "schema": []}
{"input": "The harpin-encoding hrpZ gene is located in an operon that also encodes Hrp secretion pathway components and is part of the functional cluster of hrp genes carried on cosmid pHIR11 that enables saprophytic bacteria like Escherichia coli and Pseudomonas fluorescens to elicit the HR in tobacco leaves.", "output": {"entities": {"gene": [{"text": "harpin", "start": 4, "end": 10}, {"text": "hrpZ gene", "start": 20, "end": 29}, {"text": "Hrp secretion pathway components", "start": 72, "end": 104}, {"text": "hrp genes", "start": 146, "end": 155}]}}, "schema": []}
{"input": "Despite the presence of one additional ribonucleotide reductase, the nrdAB-encoded enzyme is essential to the aerobic growth of the cell because nrdAB-defective mutants of both species are not viable in the presence of oxygen.", "output": {"entities": {"gene": [{"text": "ribonucleotide reductase", "start": 39, "end": 63}, {"text": "nrdAB-encoded enzyme", "start": 69, "end": 89}, {"text": "nrdAB-defective mutants", "start": 145, "end": 168}]}}, "schema": []}
{"input": "Altogether, the results demonstrate that the two isoforms elicit similar responses in vivo despite differences in their regulation.", "output": {"entities": {}}, "schema": []}
{"input": "Motivational factors focusing on attitudes, perceived susceptibility to pregnancy, and normative factors were also relevant.", "output": {"entities": {}}, "schema": []}
{"input": "High-resolution structure of the diphtheria toxin repressor complexed with cobalt and manganese reveals an SH3-like third domain and suggests a possible role of phosphate as co-corepressor.", "output": {"entities": {"gene": [{"text": "diphtheria toxin repressor", "start": 33, "end": 59}, {"text": "SH3-like", "start": 107, "end": 115}]}}, "schema": []}
{"input": "Titration of the human and porcine proteins with 2-nitro-5-thiosulfabenzoate indicates that membrane dipeptidase additionally possesses two intrachain disulfide bonds.", "output": {"entities": {"gene": [{"text": "membrane dipeptidase", "start": 92, "end": 112}]}}, "schema": []}
{"input": "FEV1 did not fall significantly in patients without acute or chronic GVHD and recovered earlier than in patients without posttransplant pulmonary infection.", "output": {"entities": {}}, "schema": []}
{"input": "Administration of adrenaline resulted in a large overestimation of the SaO2 in 6 of the 7 measurements.", "output": {"entities": {}}, "schema": []}
{"input": "Therapy with dietary modification and triglyceride lowering drugs resulted in resolution of symptoms and parotid swelling in one patient.", "output": {"entities": {}}, "schema": []}
{"input": "Chernoff, submitted for publication).", "output": {"entities": {}}, "schema": []}
{"input": "We have cloned a novel protein kinase, termed hematopoietic progenitor kinase 1 (HPK1), that is expressed predominantly in hematopoietic cells, including early progenitor cells.", "output": {"entities": {"gene": [{"text": "hematopoietic progenitor kinase 1", "start": 46, "end": 79}, {"text": "HPK1", "start": 81, "end": 85}]}}, "schema": []}
{"input": "Human ESP1/CRP2 protein has two LIM domains, and each shares 35. 1% and 77 or 79% identical residues with human cysteine-rich protein (CRP) and rat CRIP, respectively.", "output": {"entities": {"gene": [{"text": "ESP1", "start": 6, "end": 10}, {"text": "CRP2", "start": 11, "end": 15}, {"text": "LIM", "start": 32, "end": 35}, {"text": "human cysteine-rich protein", "start": 106, "end": 133}, {"text": "CRP", "start": 135, "end": 138}, {"text": "rat CRIP", "start": 144, "end": 152}]}}, "schema": []}
{"input": "The fragments are separated and directly sized by agarose gel electrophoresis.", "output": {"entities": {}}, "schema": []}
{"input": "Linkage studies have shown locus heterogeneity with one TSC gene mapped to chromosome 9q34 and a second to 16p13. 3.", "output": {"entities": {"gene": [{"text": "TSC gene", "start": 56, "end": 64}]}}, "schema": []}
{"input": "The cytogenetic expression of the folate sensitive fragile site, FRAXE, is due to the expansion of a GCC repeat in proximal Xq28 of the human X chromosome and is associated with a mild form of mental handicap.", "output": {"entities": {"gene": [{"text": "FRAXE", "start": 65, "end": 70}]}}, "schema": []}
{"input": "DNA sequence analysis of a 3213 bp BamHI-ClaI fragment revealed that three open reading frames (ORFs) were encoded in the same orientation.", "output": {"entities": {"gene": [{"text": "BamHI", "start": 35, "end": 40}, {"text": "ClaI", "start": 41, "end": 45}]}}, "schema": []}
{"input": "The initial inpatient experience for individuals with HIV-related TB may be pivotal to the acceptance of and participation in ongoing TB care.", "output": {"entities": {}}, "schema": []}
{"input": "This element, termed CREsp-a (TGACCTCA), differs by one nucleotide from a palindromic CRE (CREpal, TGACGTCA), which is known to bind CREB as a homodimer.", "output": {"entities": {"gene": [{"text": "CREB", "start": 133, "end": 137}]}}, "schema": []}
{"input": "Analysis of human genomic DNA reveals an intronless sequence with strong homology to human G alpha q cDNA.", "output": {"entities": {"gene": [{"text": "human G alpha q cDNA", "start": 85, "end": 105}]}}, "schema": []}
{"input": "The complete exon-intron structure of the 156-kb human gene NFKB1, which encodes the p105 and p50 proteins of transcription factors NF-kappa B and I kappa B-gamma: implications for NF-kappa B-mediated signal transduction.", "output": {"entities": {"gene": [{"text": "156-kb human gene NFKB1", "start": 42, "end": 65}, {"text": "p105", "start": 85, "end": 89}, {"text": "p50 proteins", "start": 94, "end": 106}, {"text": "NF-kappa B", "start": 132, "end": 142}, {"text": "I kappa B-gamma", "start": 147, "end": 162}, {"text": "NF-kappa B", "start": 181, "end": 191}]}}, "schema": []}
{"input": "An inverted Alu repeat element, flanked by nonamer direct repeats, was identified within the region-913/-620, relative to the cap site.", "output": {"entities": {"gene": [{"text": "Alu", "start": 12, "end": 15}]}}, "schema": []}
{"input": "Comparison of the amino acid sequences of the RPO1 polypeptides of IIV6, LCDV, and MCV-1 with the corresponding prokaryotic, eukaryotic, and viral proteins revealed differences in amino acid similarity and phylogenetic relationships.", "output": {"entities": {"gene": [{"text": "RPO1 polypeptides of IIV6, LCDV, and MCV-1", "start": 46, "end": 88}]}}, "schema": []}
{"input": "The RPO1 of LCDV shows the highest similarity to the RPO1 of IIV6 and significant lower similarity to the eukaryotic polymerases II and III as well as to the archaebacteral subunit.", "output": {"entities": {"gene": [{"text": "RPO1", "start": 4, "end": 8}, {"text": "RPO1", "start": 53, "end": 57}, {"text": "eukaryotic polymerases II and III", "start": 106, "end": 139}]}}, "schema": []}
{"input": "The use of primary GE cells thus provides a convenient in vitro system for further study of the endocrine, paracrine, and autocrine factors regulating endometrial gene expression during pregnancy.", "output": {"entities": {}}, "schema": []}
{"input": "We performed dipole estimation of spikes and SEP components in identical patients.", "output": {"entities": {}}, "schema": []}
{"input": "Proximal CBD was inversely correlated with bone alkaline phosphatase (r =-0. 71, p < 0. 01) and intact PTH (r =-0. 59, p < 0. 05).", "output": {"entities": {"gene": [{"text": "bone alkaline phosphatase", "start": 43, "end": 68}, {"text": "PTH", "start": 103, "end": 106}]}}, "schema": []}
{"input": "In addition, a comparison of the hCHLR gene sequences with available databases indicates that a large portion of these genes, including exons encoding two functional domains of the carboxyl-terminal region of these proteins, has been duplicated as part of a larger human telomeric repeat sequence found on many human chromosomes.", "output": {"entities": {"gene": [{"text": "hCHLR gene sequences", "start": 33, "end": 53}]}}, "schema": []}
{"input": "We show here that the LIM domain homeobox protein isl-1 activates the rat amylin promoter in both fibroblast and islet cell lines.", "output": {"entities": {"gene": [{"text": "LIM domain homeobox protein isl-1", "start": 22, "end": 55}, {"text": "rat amylin promoter", "start": 70, "end": 89}]}}, "schema": []}
{"input": "Although isl-1 binds to both the insulin and amylin gene promoter elements in vitro, these sequences display marked differences in their relative transcriptional properties when ligated adjacent to a heterologous promoter and transfected into InR1-G9 islet cells.", "output": {"entities": {"gene": [{"text": "isl-1", "start": 9, "end": 14}, {"text": "insulin", "start": 33, "end": 40}, {"text": "amylin gene promoter elements", "start": 45, "end": 74}]}}, "schema": []}
{"input": "It is likely that other pathways involve alternate signal transduction events (e. g., calcium mobilization) and promoter response elements (e. g., SRE).", "output": {"entities": {}}, "schema": []}
{"input": "The CD4 count at which remission occurs may reflect severe immunodeficiency such that risk for AIDS-related infection is high.", "output": {"entities": {"gene": [{"text": "CD4", "start": 4, "end": 7}]}}, "schema": []}
{"input": "Although diagnostic laparoscopy is still considered the standard reference in the diagnosis of ectopic pregnancy (EP), use of high-resolution endovaginal sonography, in conjunction with qualitative serum assays of the beta subunit of human chorionic gonadotropin (beta-hCG), allows detection of earlier and smaller EPs.", "output": {"entities": {"gene": [{"text": "human chorionic gonadotropin", "start": 234, "end": 262}, {"text": "beta-hCG", "start": 264, "end": 272}]}}, "schema": []}
{"input": "Bifunctionality of the AcMNPV homologous region sequence (hr1): enhancer and ori functions have different sequence requirements.", "output": {"entities": {"gene": [{"text": "AcMNPV homologous region sequence", "start": 23, "end": 56}, {"text": "hr1", "start": 58, "end": 61}]}}, "schema": []}
{"input": "Neither CES1 nor CES4 is essential for cell growth, and a double deletion mutant is viable.", "output": {"entities": {"gene": [{"text": "CES1", "start": 8, "end": 12}, {"text": "CES4", "start": 17, "end": 21}]}}, "schema": []}
{"input": "Their use established that the BrAAP activity catalyzed both a postproline and a postglutamate cleavage and therefore has a broader specificity than previously recognized.", "output": {"entities": {}}, "schema": []}
{"input": "To explore the functional significance of these subdomains in PRL binding and signal transduction, deletion mutants of S1 or/and S2 subdomains were constructed.", "output": {"entities": {"gene": [{"text": "PRL", "start": 62, "end": 65}]}}, "schema": []}
{"input": "A stable heterologous cell line containing the mouse TRH receptor was constructed by transfection of nonexcitable 293 cells, which lack L channel activity.", "output": {"entities": {"gene": [{"text": "mouse TRH receptor", "start": 47, "end": 65}]}}, "schema": []}
{"input": "To understand further the expression and regulation of the V1aR, we now describe the genomic characteristics, tissue expression, chromosomal localization, and regional mapping of the human V1aR gene, AVPR1A.", "output": {"entities": {"gene": [{"text": "V1aR", "start": 59, "end": 63}, {"text": "human V1aR gene", "start": 183, "end": 198}, {"text": "AVPR1A", "start": 200, "end": 206}]}}, "schema": []}
{"input": "The final predicted structure has an overall backbone deviation of 0. 7 A from that of ras-p21.", "output": {"entities": {"gene": [{"text": "ras", "start": 87, "end": 90}, {"text": "p21", "start": 91, "end": 94}]}}, "schema": []}
{"input": "Genomic organization of the human beta-catenin gene (CTNNB1).", "output": {"entities": {"gene": [{"text": "human beta-catenin gene", "start": 28, "end": 51}, {"text": "CTNNB1", "start": 53, "end": 59}]}}, "schema": []}
{"input": "Furthermore, although the regional distribution of lean tissue mass in the trunk and legs remained fairly constant at different pubertal stages, the regional distribution of fat was altered significantly, becoming more central and less peripheral.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, the predicted CD30v protein retains most of the cytoplasmic region, but lacks the extracellular and transmembrane domains.", "output": {"entities": {"gene": [{"text": "CD30v protein", "start": 20, "end": 33}]}}, "schema": []}
{"input": "Constitutive phosphorylation of the CD30v protein was demonstrated by in vitro labeling with [32P].", "output": {"entities": {"gene": [{"text": "CD30v protein", "start": 36, "end": 49}]}}, "schema": []}
{"input": "17. 5% of cycles).", "output": {"entities": {}}, "schema": []}
{"input": "We report here the discovery of a new actin-related gene in this organism, which we have named ACT4.", "output": {"entities": {"gene": [{"text": "actin-related gene", "start": 38, "end": 56}, {"text": "ACT4", "start": 95, "end": 99}]}}, "schema": []}
{"input": "Two of the ORFs are completely internal to longer ones and a third is partially embedded in G2850.", "output": {"entities": {"gene": [{"text": "G2850", "start": 92, "end": 97}]}}, "schema": []}
{"input": "MVR typing of rare-length alleles indicates that they are comprised of disorganized sequences, although they usually bear a resemblance to one of the common alleles at the 5'-most end.", "output": {"entities": {}}, "schema": []}
{"input": "Plasmid pAL618 contains the genetic determinants for H2 uptake (hup) from Rhizobium leguminosarum bv. viciae, including a cluster of 17 genes named hupSLCDEFGHIJK-hypABFCDE.", "output": {"entities": {"gene": [{"text": "hup", "start": 64, "end": 67}, {"text": "hupSLCDEFGHIJK-hypABFCDE", "start": 148, "end": 172}]}}, "schema": []}
{"input": "An open-label, placebo-controlled, randomized, two-way crossover study was performed in 12 healthy volunteers (between 20 and 44 years of age) to assess the effect of orlistat, a gastrointestinal lipase inhibitor that reduces dietary fat absorption and is being developed for weight control in obesity, on the absorption of vitamins A and E.", "output": {"entities": {"gene": [{"text": "gastrointestinal lipase", "start": 179, "end": 202}]}}, "schema": []}
{"input": "Tilmicosin is a novel macrolide antibiotic developed for exclusive use in veterinary medicine.", "output": {"entities": {}}, "schema": []}
{"input": "Effect of nitrous oxide (N2O) on the somatosympathetic A-and C-reflexes was investigated using artificially ventilated rats anesthetized with alpha-chloralose and urethane.", "output": {"entities": {}}, "schema": []}
{"input": "Restriction enzyme mapping and Southern analysis indicated further that the human MZF-1 gene is a single-copy gene.", "output": {"entities": {"gene": [{"text": "human MZF-1 gene", "start": 76, "end": 92}]}}, "schema": []}
{"input": "In the absence of Swi4 and Swi6 cell viability is lost, but can be regained by ectopic expression of the G1 cyclin encoding genes, CLN1 or CLN2.", "output": {"entities": {"gene": [{"text": "Swi4", "start": 18, "end": 22}, {"text": "Swi6", "start": 27, "end": 31}, {"text": "G1 cyclin encoding genes", "start": 105, "end": 129}, {"text": "CLN1", "start": 131, "end": 135}, {"text": "CLN2", "start": 139, "end": 143}]}}, "schema": []}
{"input": "The detection ratio peaked at ages 30 to 34 and decreased heavily during the next 15 years of age.", "output": {"entities": {}}, "schema": []}
{"input": "How many embryos to transfer in patients undergoing IVF?", "output": {"entities": {}}, "schema": []}
{"input": "The nonconsensus TATA box in promoter B plays a more important role in promoter activity than the TATA box in promoter A.", "output": {"entities": {}}, "schema": []}
{"input": "These properties indicate that Gle1 is an RNA-export factor and that Rev may mediate viral RNA export by mimicking the function of Gle1.", "output": {"entities": {"gene": [{"text": "Gle1", "start": 31, "end": 35}, {"text": "Rev", "start": 69, "end": 72}, {"text": "Gle1", "start": 131, "end": 135}]}}, "schema": []}
{"input": "Demispan is a reliable and reproducible measure of stature in the elderly.", "output": {"entities": {}}, "schema": []}
{"input": "Two techniques based on assay coefficients of variation were employed to characterize a normal circadian pattern of cortisol.", "output": {"entities": {}}, "schema": []}
{"input": "A system is described in which the volume flow rate of blood in a vessel is determined using transverse colour Doppler ultrasound imaging.", "output": {"entities": {}}, "schema": []}
{"input": "The enzyme activities studied are important elements in the pathophysiology of dental caries and may even be addressed as virulence factors.", "output": {"entities": {}}, "schema": []}
{"input": "In lean mice, the fat/water intensity ratio was about 1: 4, about half that in normal mice.", "output": {"entities": {}}, "schema": []}
{"input": "Pharmacokinetic parameters were similar to values given in the literature for intravenous (IV) or intraarterial (IA) bolus MMC injections (Tmax = 7. 0 min following the beginning of MMC infusion, Vss = 0. 57 1/kg, C1 = 8. 9 ml/min. kg, T1/2 alpha = 8. 3 min, T1/2 beta = 58. 6 min).", "output": {"entities": {}}, "schema": []}
{"input": "In this study, we identified four distinct E2F complexes present in aged and senescent normal, human diploid fibroblasts.", "output": {"entities": {"gene": [{"text": "E2F complexes", "start": 43, "end": 56}]}}, "schema": []}
{"input": "This paper gives an overview of the global pattern of casualties in earthquakes which occurred during the 30-month period from 1 September 1993 to 29 February 1996.", "output": {"entities": {}}, "schema": []}
{"input": "If we apply the finding of non-visualization of the GB at 4 h post injection as the criterion for the diagnosis of AC, the diagnostic accuracy was only 40. 7% (11/27).", "output": {"entities": {}}, "schema": []}
{"input": "Alternative processing of the tryptophanyl-tRNA synthetase mRNA from interferon-treated human cells.", "output": {"entities": {"gene": [{"text": "tryptophanyl-tRNA synthetase mRNA", "start": 30, "end": 63}, {"text": "interferon", "start": 69, "end": 79}]}}, "schema": []}
{"input": "Evidence for the promoting role of the intra-uterine kinin release in the development of late hypertonic saline-induced abortion.", "output": {"entities": {"gene": [{"text": "intra-uterine kinin", "start": 39, "end": 58}]}}, "schema": []}
{"input": "This GAP activity was observed in 3T3-L1 adipocyte lysates, and was able to accelerate the hydrolysis of the [alpha-32P] GTP bound to GST-Rab4 into [alpha-32P] GDP.", "output": {"entities": {"gene": [{"text": "GAP", "start": 5, "end": 8}, {"text": "GST", "start": 134, "end": 137}, {"text": "Rab4", "start": 138, "end": 142}]}}, "schema": []}
{"input": "CONCLUSION: During chronic treatment, the haemodynamic response to oral cilazapril was attenuated, indicating that continued clinical improvement in patients with CHF on CLZ is independent of to its acute haemodynamic effects.", "output": {"entities": {}}, "schema": []}
{"input": "We conclude that, in AIDS patients with cryptococcosis, tolerance to ILd-AmB was acceptable when the daily dosage did not exceed 1 mg/kg, but the higher 1. 5 mg/kg daily dosage was associated with an unacceptable rate of nephrotoxicity.", "output": {"entities": {}}, "schema": []}
{"input": "Moreover, the second RCC1-like motif located at the amino-terminus of p619 stimulates guanine nucleotide exchange on ARF1 and on members of the related Rab proteins, but not on other small GTP binding proteins such as Ran or R-Ras2/TC21.", "output": {"entities": {"gene": [{"text": "RCC1-like motif", "start": 21, "end": 36}, {"text": "p619", "start": 70, "end": 74}, {"text": "ARF1", "start": 117, "end": 121}, {"text": "Rab proteins", "start": 152, "end": 164}, {"text": "small GTP binding proteins", "start": 183, "end": 209}, {"text": "Ran", "start": 218, "end": 221}, {"text": "R-Ras2", "start": 225, "end": 231}, {"text": "TC21", "start": 232, "end": 236}]}}, "schema": []}
{"input": "The reconstituted RNA polymerases containing the mutant alpha subunits were examined for their response to transcription activation by cAMP-CRP and the rrnBP1 UP element.", "output": {"entities": {"gene": [{"text": "RNA polymerases", "start": 18, "end": 33}, {"text": "cAMP-CRP", "start": 135, "end": 143}, {"text": "rrnBP1 UP element", "start": 152, "end": 169}]}}, "schema": []}
{"input": "Transcription factor recognition surface on the RNA polymerase alpha subunit is involved in contact with the DNA enhancer element.", "output": {"entities": {"gene": [{"text": "RNA polymerase alpha subunit", "start": 48, "end": 76}]}}, "schema": []}
{"input": "Consistent with this similarity, the cdc28-P8 mutant accumulates unspliced precursors at the restrictive temperature.", "output": {"entities": {"gene": [{"text": "cdc28", "start": 37, "end": 42}]}}, "schema": []}
{"input": "A decrease of erythrocyte Mn with age, expressed in nmol/L, was noted (p < 0. 02).", "output": {"entities": {}}, "schema": []}
{"input": "Cloning and sequence analyses revealed a second cDNA with a 95-nt deletion in the region coding for the putative second intracellular loop and the fourth transmembrane domain of the 5-HT2C-R.", "output": {"entities": {"gene": [{"text": "5-HT2C-R", "start": 182, "end": 190}]}}, "schema": []}
{"input": "Expression of thymidine kinase gene in normal human diploid cells is both cell cycle-and age-dependent and appears to be transcriptionally regulated.", "output": {"entities": {"gene": [{"text": "thymidine kinase gene", "start": 14, "end": 35}]}}, "schema": []}
{"input": "The minimum inhibitory concentrations (MICs) of ketoconazole, miconazole, itraconazole, fluconazole, and amphotericin B were significantly influenced by the inoculum size, regardless of the techniques used.", "output": {"entities": {}}, "schema": []}
{"input": "These bacteria produce and export proteins capable of specific interactions with key mammalian cell regulatory molecules in order to derail the normal functions of the cells.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, although p28 may play only a limited role during the early embryonic cleavages, it may function later in development to establish a somatic type of cell cycle.", "output": {"entities": {"gene": [{"text": "p28", "start": 15, "end": 18}]}}, "schema": []}
{"input": "The main aim of the contribution, which opens an arena for discussion on the Rivista dell' Infermiere is to critically appraise published research works focusing both on strengths and novelty and weaknesses in the hypothesis formulation, methods and instruments used, discussion of results.", "output": {"entities": {}}, "schema": []}
{"input": "Moreover, it also discusses the effects of antihypertensive drugs currently regarded as first-choice agents, i. e. calcium antagonists and the angiotensin converting enzyme inhibitors, on intrarenal hemodynamics.", "output": {"entities": {"gene": [{"text": "angiotensin converting enzyme", "start": 143, "end": 172}]}}, "schema": []}
{"input": "It is suggested that the observed clinical phenomena in response to morphine can be explained by differences in expression and sensitivity of some opioid receptor subtypes in migraine.", "output": {"entities": {"gene": [{"text": "opioid receptor", "start": 147, "end": 162}]}}, "schema": []}
{"input": "Previous studies demonstrated that the flavin-containing monooxygenases (FMO) are expressed in a tissue-specific manner.", "output": {"entities": {"gene": [{"text": "flavin-containing monooxygenases", "start": 39, "end": 71}, {"text": "FMO", "start": 73, "end": 76}]}}, "schema": []}
{"input": "Thus, despite the potential for common regulatory mechanisms, the available evidence indicates that the Mtx minimal promoter does not significantly affect Thbs3 gene expression.", "output": {"entities": {"gene": [{"text": "Mtx minimal promoter", "start": 104, "end": 124}, {"text": "Thbs3 gene", "start": 155, "end": 165}]}}, "schema": []}
{"input": "MSSP proteins have been identified by their binding to an upstream element of c-myc.", "output": {"entities": {"gene": [{"text": "MSSP proteins", "start": 0, "end": 13}, {"text": "c-myc", "start": 78, "end": 83}]}}, "schema": []}
{"input": "Gene 1 has been completely sequenced.", "output": {"entities": {"gene": [{"text": "Gene 1", "start": 0, "end": 6}]}}, "schema": []}
{"input": "B cell antigen receptor (BCR)-induced apoptosis in the WEHI-231 B lymphoma cell line can be prevented by engaging CD40.", "output": {"entities": {"gene": [{"text": "B cell antigen receptor", "start": 0, "end": 23}, {"text": "BCR", "start": 25, "end": 28}, {"text": "CD40", "start": 114, "end": 118}]}}, "schema": []}
{"input": "Both alleles are functionally expressed and are distributed within CD4 +/CD8 + T cell subsets.", "output": {"entities": {"gene": [{"text": "CD4", "start": 67, "end": 70}, {"text": "CD8", "start": 73, "end": 76}]}}, "schema": []}
{"input": "The deduced amino acid sequence of LvUSF2 is nearly identical to LvUSF1 except at the amino end, where they are sharply divergent.", "output": {"entities": {"gene": [{"text": "LvUSF2", "start": 35, "end": 41}, {"text": "LvUSF1", "start": 65, "end": 71}]}}, "schema": []}
{"input": "ECM disruption in Lytechinus embryos caused a relative drop in USF RNA accumulation levels to approximately 60% of control embryos, while LpS1 RNA accumulation levels dropped to less than 5%.", "output": {"entities": {"gene": [{"text": "USF RNA", "start": 63, "end": 70}, {"text": "LpS1 RNA", "start": 138, "end": 146}]}}, "schema": []}
{"input": "Five of these eight patients in group II also received 8-in-1 chemotherapy.", "output": {"entities": {}}, "schema": []}
{"input": "Sixty days after the intervention, twitch and tetanic tensions remained dependent upon the extracellular Ca2 + concentration ([Ca] o) both in groups A and B.", "output": {"entities": {}}, "schema": []}
{"input": "Recently, a distantly related UmuC-homolog, DinB, has also been identified in E. coli.", "output": {"entities": {"gene": [{"text": "UmuC-homolog", "start": 30, "end": 42}, {"text": "DinB", "start": 44, "end": 48}]}}, "schema": []}
{"input": "To study the regulation of mdr2 expression, the promoter of the mdr2 gene has been isolated from a murine vinblastine-resistant cell line, J7. V2-1, and characterized.", "output": {"entities": {"gene": [{"text": "mdr2", "start": 27, "end": 31}, {"text": "mdr2 gene", "start": 64, "end": 73}]}}, "schema": []}
{"input": "The amplification was achieved using two primers which correspond to TRH progenitor sequence (Lys/Arg-Arg-Gln-His-Pro-Gly-Lys/Arg-Arg).", "output": {"entities": {"gene": [{"text": "TRH progenitor sequence", "start": 69, "end": 92}]}}, "schema": []}
{"input": "The intranodal mesothelial cells occupied the sinusoids of the lymph nodes and were initially suspected of being metastatic from the ovarian tumor in each case.", "output": {"entities": {}}, "schema": []}
{"input": "The gene ccpA encoding the catabolite control protein CcpA of Staphylococcus xylosus has been cloned and characterized.", "output": {"entities": {"gene": [{"text": "gene ccpA", "start": 4, "end": 13}, {"text": "catabolite control protein CcpA", "start": 27, "end": 58}]}}, "schema": []}
{"input": "An InlC deletion mutant shows reduced virulence when tested in an intravenous mouse model, but intracellular replication of the mutant in Caco-2 and J774 cells appears to be comparable with that of the wild-type strain.", "output": {"entities": {"gene": [{"text": "InlC deletion mutant", "start": 3, "end": 23}]}}, "schema": []}
{"input": "Thus, the N-Nus complex may be affected through contacts with the CTD of the alpha subunit of RNA polymerase, as is a group of regulatory proteins that influences initiation of transcription.", "output": {"entities": {"gene": [{"text": "N", "start": 10, "end": 11}, {"text": "Nus", "start": 12, "end": 15}, {"text": "RNA polymerase", "start": 94, "end": 108}]}}, "schema": []}
{"input": "Administration of RIFA at 200 mg/kg/day in combination with ATO at 100 mg/kg/day resulted in a marked prolongation of survival compared with that for mice that received ATO or RIFA alone.", "output": {"entities": {}}, "schema": []}
{"input": "Two of seven initiation sites were flanked by a sequence homologous to the consensus promoter motif that includes the CRTA motif (where R is A or G) of the rice mitochondrion.", "output": {"entities": {}}, "schema": []}
{"input": "Selection using SC EPD was more effective than phenotypic selection in reducing age at puberty in daughters.", "output": {"entities": {}}, "schema": []}
{"input": "Sodium polystyrene sulfonate treatment for lithium toxicity: effects on serum potassium concentrations.", "output": {"entities": {}}, "schema": []}
{"input": "The mammalian homeodomain proteins encoded by Hox genes play an important role in embryonic development by providing positional queues which define developmental identities along the anteroposterior axis of developing organisms.", "output": {"entities": {"gene": [{"text": "mammalian homeodomain proteins", "start": 4, "end": 34}, {"text": "Hox genes", "start": 46, "end": 55}]}}, "schema": []}
{"input": "Interferon stimulated gene factor 3 (ISGF3) is a trimeric transcription factor activated on treatment of cells with interferon-alpha and beta (type I IFNs).", "output": {"entities": {"gene": [{"text": "Interferon stimulated gene factor 3", "start": 0, "end": 35}, {"text": "ISGF3", "start": 37, "end": 42}, {"text": "interferon-alpha and beta", "start": 116, "end": 141}, {"text": "type I IFNs", "start": 143, "end": 154}]}}, "schema": []}
{"input": "The TYAC/P1 resource, derivative STSs, and polymorphisms constitute an enabling resource to further studies of telomere structure and function and a means for physical and genetic map integration and closure.", "output": {"entities": {}}, "schema": []}
{"input": "Confirmatory statistics included item 2 of the Clinical Global Impression (CGI), the total score of the Sandoz Clinical Assessment Geriatric (SCAG) scale, the subscale' need for help' of the nurse' s rating of geriatric patients (Beurteilungsskala fur geriatrische Patienten; BGP) and the total score of the Short Cognitive Performance Test (Syndrom-Kurztest; SKT).", "output": {"entities": {}}, "schema": []}
{"input": "Three mutants were isolated from the widely used strain, PAO1.", "output": {"entities": {}}, "schema": []}
{"input": "As extensively examined with the myogenin promoter, presence of one or multiple copies of Me in the vectors elevated the expression activity in myotubes by 4. 5-to 19-fold over those without Me, but not significantly in myoblasts.", "output": {"entities": {"gene": [{"text": "myogenin promoter", "start": 33, "end": 50}, {"text": "Me", "start": 90, "end": 92}, {"text": "Me", "start": 191, "end": 193}]}}, "schema": []}
{"input": "We conclude that common upstream signals cause activation of Ras and TC21, but activated TC21 controls cell growth via distinct Raf-independent downstream signaling pathways.", "output": {"entities": {"gene": [{"text": "Ras", "start": 61, "end": 64}, {"text": "TC21", "start": 69, "end": 73}, {"text": "TC21", "start": 89, "end": 93}, {"text": "Raf", "start": 128, "end": 131}]}}, "schema": []}
{"input": "Fission yeast mal2 + is required for chromosome segregation.", "output": {"entities": {"gene": [{"text": "Fission yeast mal2 +", "start": 0, "end": 20}]}}, "schema": []}
{"input": "Selection was based on expression of an integrated DNA fragment containing the con-10 promoter-regulatory region followed by the initial segment of the con-10 open reading frame fused in frame with the bacterial hygromycin B phosphotransferase structural gene (con10'-' hph).", "output": {"entities": {"gene": [{"text": "con-10 promoter-regulatory region", "start": 79, "end": 112}, {"text": "con-10 open reading frame", "start": 152, "end": 177}, {"text": "bacterial hygromycin B phosphotransferase structural gene", "start": 202, "end": 259}, {"text": "con10'-' hph", "start": 261, "end": 273}]}}, "schema": []}
{"input": "Mutations at two neighboring sites, serine 242 and threonine 255, exacerbated the effect.", "output": {"entities": {}}, "schema": []}
{"input": "IRF-1 acts as a transcriptional activator, while IRF-2 acts as a repressor.", "output": {"entities": {"gene": [{"text": "IRF-1", "start": 0, "end": 5}, {"text": "IRF-2", "start": 49, "end": 54}]}}, "schema": []}
{"input": "In contrast, cotransfection of TFIIB and IRF-1 into NIH 3T3 cells resulted in a dose-dependent repression of promoter activation which occurred in a TATA-dependent manner.", "output": {"entities": {"gene": [{"text": "TFIIB", "start": 31, "end": 36}, {"text": "IRF-1", "start": 41, "end": 46}]}}, "schema": []}
{"input": "The requirement of Tyr-19 dephosphorylation for spindle assembly is also observed under conditions in which spindle formation is independent of mitosis, suggesting that the involvement of Cdc28/Clb kinase in SPB separation is direct.", "output": {"entities": {"gene": [{"text": "Cdc28", "start": 188, "end": 193}, {"text": "Clb", "start": 194, "end": 197}]}}, "schema": []}
{"input": "Expression of the proapoptotic protein Bax under the control of a GAL10 promoter in Saccharomyces cerevisiae resulted in galactose-inducible cell death.", "output": {"entities": {"gene": [{"text": "proapoptotic protein Bax", "start": 18, "end": 42}, {"text": "GAL10 promoter", "start": 66, "end": 80}]}}, "schema": []}
{"input": "This technique was employed in 12 patients with a unicameral bone cyst.", "output": {"entities": {}}, "schema": []}
{"input": "The amino-terminal region of E1A binds several high molecular weight proteins and inhibits the transcriptional coactivator function of p300 and the homologous cAMP response element (CRE)-binding protein.", "output": {"entities": {"gene": [{"text": "E1A", "start": 29, "end": 32}, {"text": "p300", "start": 135, "end": 139}, {"text": "cAMP response element (CRE)-binding protein", "start": 159, "end": 202}]}}, "schema": []}
{"input": "Transient transfection assays using reporter gene constructs containing various lengths of the 5' mdr1b sequences revealed that the sequence located between-247 to-126 bp was important for the expression of the reporter gene in many different cell lines.", "output": {"entities": {"gene": [{"text": "5' mdr1b sequences", "start": 95, "end": 113}]}}, "schema": []}
{"input": "We show that the 5' UTR characteristic of testis-specific c-mos mRNA strongly represses translation relative to the translation of transcripts that contain a 5' UTR derived from beta-globin mRNA, and this is mainly due to the four uORFs.", "output": {"entities": {"gene": [{"text": "testis-specific c-mos mRNA", "start": 42, "end": 68}, {"text": "beta-globin mRNA", "start": 178, "end": 194}]}}, "schema": []}
{"input": "To address the biological effect of specific isoform expression, NIH3T3 cells were transfected with a eukaryotic expression vector containing cDNA for FGF8a, FGF8b, or FGF8e.", "output": {"entities": {"gene": [{"text": "FGF8a", "start": 151, "end": 156}, {"text": "FGF8b", "start": 158, "end": 163}, {"text": "FGF8e", "start": 168, "end": 173}]}}, "schema": []}
{"input": "These findings suggest that the F-wave may be elicited in motoneuron of different depolarization threshold but primarily in larger and faster nerve fibers, with a lower threshold of depolarization.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, carp JAK1 shows higher sequence homology to mammalian JAK1 in both the kinase-like (JH2) and kinase (JH1) domains (approximately 70% identity).", "output": {"entities": {"gene": [{"text": "carp JAK1", "start": 13, "end": 22}, {"text": "mammalian JAK1", "start": 57, "end": 71}, {"text": "JH2", "start": 97, "end": 100}, {"text": "JH1", "start": 114, "end": 117}]}}, "schema": []}
{"input": "When this DNA fragment was placed upstream of the chloramphenicol acetyltransferase (CAT) reporter gene and transfected into a carp CF cell line, it could drive the synthesis of CAT enzyme 16 times more efficiently than the promoterless pCAT-Basic.", "output": {"entities": {"gene": [{"text": "chloramphenicol acetyltransferase", "start": 50, "end": 83}, {"text": "CAT", "start": 85, "end": 88}, {"text": "CAT enzyme", "start": 178, "end": 188}, {"text": "pCAT-Basic", "start": 237, "end": 247}]}}, "schema": []}
{"input": "Molecular cloning of Elk-3, a new member of the Ets family expressed during mouse embryogenesis and analysis of its transcriptional repression activity.", "output": {"entities": {"gene": [{"text": "Elk-3", "start": 21, "end": 26}, {"text": "Ets family", "start": 48, "end": 58}]}}, "schema": []}
{"input": "We report an example of an MDV-transformed T-lymphoblastoid cell line (T9) expressing high levels of a truncated C-MYB protein as a result of RAV integration within one c-myb allele.", "output": {"entities": {"gene": [{"text": "truncated C-MYB protein", "start": 103, "end": 126}, {"text": "c-myb allele", "start": 169, "end": 181}]}}, "schema": []}
{"input": "Frozen/thawed extensor digitorum longus muscle tendon units had significantly lower values for load to failure (p < 0. 01), energy absorbed to failure (p < 0. 01), and strain at failure (p < 0. 01), and they tended to fail at a different anatomic location (p < 0. 01) (broadly at the fascia-muscle interface as compared with horizontally at the musculotendinous junction) than fresh units.", "output": {"entities": {}}, "schema": []}
{"input": "Northern analysis of the 3. 1-kb PWP2H cDNA revealed that a 3. 3-kb major transcript is ubiquitously expressed in human adult tissues.", "output": {"entities": {"gene": [{"text": "3. 1-kb PWP2H cDNA", "start": 25, "end": 43}]}}, "schema": []}
{"input": "Forty-eight 10-12-week-old male Sprague-Dawley rats were randomized to receive, daily for 28 days: (1) CsA vehicle p. o. plus FB vehicle sc; (2) CsA (15 mg/kg) p. o. plus FB vehicle sc, (3) CsA vehicle p. o. plus FB (1. 5 mg/kg) sc; and (4) CsA (15 mg/kg) p. o. plus FB (1. 5 mg/kg) sc.", "output": {"entities": {}}, "schema": []}
{"input": "CsA alone resulted in elevated bone turnover.", "output": {"entities": {}}, "schema": []}
{"input": "Individuals attending the GUM Department in the Royal Infirmary of Edinburgh between 1990 and 1994 with the diagnosis of HIV infection, genital warts, genital herpes, non-specific genital infection (NSGI), gonorrhoea and syphilis were included in the study.", "output": {"entities": {}}, "schema": []}
{"input": "Northern blotting showed that MDMX, like MDM2, is expressed in all tissues tested, and that several mRNAs for MDMX can be detected.", "output": {"entities": {"gene": [{"text": "MDMX", "start": 30, "end": 34}, {"text": "MDM2", "start": 41, "end": 45}, {"text": "MDMX", "start": 110, "end": 114}]}}, "schema": []}
{"input": "The nucleotide sequence of 22, 846 bp of the left arm of chromosome IV is described.", "output": {"entities": {}}, "schema": []}
{"input": "Natural FL protein has been purified from a stromal cell line and shown to be a 65 kD nondisulfide-linked homodimeric glycoprotein comprised of 30 kD subunits, each containing 12 kD of N-and O-linked sugars.", "output": {"entities": {"gene": [{"text": "FL protein", "start": 8, "end": 18}]}}, "schema": []}
{"input": "The objective of this study was to examine the influence of HHCA and other serological factors upon the development of VGS.", "output": {"entities": {}}, "schema": []}
{"input": "Spliced exons of adenovirus late RNAs colocalize with snRNP in a specific nuclear domain.", "output": {"entities": {}}, "schema": []}
{"input": "Using Spurr' s resin as a mounting medium, we could observe thick specimens with oil immersion objective lens without the use of coverslips, then avoid air bubbles near the specimen.", "output": {"entities": {}}, "schema": []}
{"input": "The present study investigated dose dependence and time course effects of the benzodiazepine (BDZ) partial inverse agonist, RO19-4603 (0. 005-0. 30 mg/kg) alone, and in combination with the BDZ receptor antagonists flumazenil, ZK 93426, and CGS 8216 (20 mg/kg) in selectively bred alcohol-preferring (P) rats provided a two-bottle choice test between ethanol (EtOH) (10% v/v), and a palatable saccharin (0. 0125% g/v) solution.", "output": {"entities": {"gene": [{"text": "BDZ receptor", "start": 190, "end": 202}]}}, "schema": []}
{"input": "Beyond the Tower of Babel: a nomenclature for suicidology.", "output": {"entities": {}}, "schema": []}
{"input": "Infection with Neisseria meningitidis group B has been difficult to detect, partly because this bacterial group' s polysaccharide is a weak immunogen.", "output": {"entities": {}}, "schema": []}
{"input": "Rss1p encodes a novel essential protein of 538 amino acids, which contains an extended predicted coiled-coil domain and is located both at nuclear pore complexes (NPCs) and in the cytoplasm.", "output": {"entities": {"gene": [{"text": "Rss1p", "start": 0, "end": 5}]}}, "schema": []}
{"input": "To map this regulatory serine phosphorylation site we developed a baculovirus-mediated expression system for wild-type annexin II and for a series of annexin II mutants which contained substitutions in one or more serine residues present in the N-terminal domain.", "output": {"entities": {"gene": [{"text": "wild-type annexin II", "start": 109, "end": 129}, {"text": "annexin II mutants", "start": 150, "end": 168}]}}, "schema": []}
{"input": "The PAI-2 gene is one of the most TNF-responsive genes known and is also highly induced by the phorbol ester phorbol 12-myristate 13-acetate (PMA) and the phosphatase inhibitor, okadaic acid, in both HT-1080 fibrosarcoma and U-937 histiocytic cells.", "output": {"entities": {"gene": [{"text": "PAI-2 gene", "start": 4, "end": 14}, {"text": "TNF-responsive genes", "start": 34, "end": 54}]}}, "schema": []}
{"input": "220, 263-273).", "output": {"entities": {}}, "schema": []}
{"input": "T., Patel, S.", "output": {"entities": {}}, "schema": []}
{"input": "Growth factors induce the expression of the immediate early gene products MAP kinase phosphatase-1 (MKP-1), c-Fos and c-Jun.", "output": {"entities": {"gene": [{"text": "immediate early gene products MAP kinase phosphatase-1", "start": 44, "end": 98}, {"text": "MKP-1", "start": 100, "end": 105}, {"text": "c-Fos", "start": 108, "end": 113}, {"text": "c-Jun", "start": 118, "end": 123}]}}, "schema": []}
{"input": "The up-regulation of E-selectin, one of the adhesion molecules on the endothelium, is an important event in the mediation of the inflammatory response.", "output": {"entities": {"gene": [{"text": "E-selectin", "start": 21, "end": 31}]}}, "schema": []}
{"input": "The NIT2 protein is localised in nuclei and could not be detected in the cytoplasmic fraction of cells subjected to nitrogen derepression or nitrogen repression, indicating that the nuclear import of NIT2 is not regulated.", "output": {"entities": {"gene": [{"text": "NIT2 protein", "start": 4, "end": 16}, {"text": "NIT2", "start": 200, "end": 204}]}}, "schema": []}
{"input": "In spite of much effort, no one has succeeded in isolating and characterizing the enzyme (s) responsible for synthesis of cellulose, the major cell wall polymer of plants.", "output": {"entities": {}}, "schema": []}
{"input": "Vascular responses to reactive hyperemia (with flow increase leading to endothelium-dependent dilation) and to sublingual glyceryl trinitrate (GTN; endothelium-independent dilation) were recorded.", "output": {"entities": {}}, "schema": []}
{"input": "During this period, administration of additional exogenous PRL did not stimulate further activation (binding) of the Stat factors.", "output": {"entities": {"gene": [{"text": "exogenous PRL", "start": 49, "end": 62}, {"text": "Stat factors", "start": 117, "end": 129}]}}, "schema": []}
{"input": "Intraperitoneal administration of L-5-hydroxytryptophan (L-5-HTP) at doses of 25 to 100 mg/kg dramatically increase defecation in mice.", "output": {"entities": {}}, "schema": []}
{"input": "In the VA-SMV mode, the connection was made with valved conduits from the LV apex (inflow) to the ascending aorta (outflow) (n = 11) or to the DAo (n = 12).", "output": {"entities": {}}, "schema": []}
{"input": "Factor V Leiden is a genetic disorder associated with an increased risk of venous thrombosis.", "output": {"entities": {}}, "schema": []}
{"input": "This is the first determination of the complete secondary structure of an RNA spliced in a spliceosome.", "output": {"entities": {}}, "schema": []}
{"input": "The majority of the cases with 0-I or 0-III components were sm. cancer.", "output": {"entities": {}}, "schema": []}
{"input": "These patients appear to have slightly better pulmonary function and nutritional status; yet, they seem to have a higher degree of health care utilization.", "output": {"entities": {}}, "schema": []}
{"input": "This observation calls for careful monitoring of calcium and alkaline phosphatase values and possible adjustments of vitamin D intake when fortifiers are used for extended periods.", "output": {"entities": {"gene": [{"text": "alkaline phosphatase", "start": 61, "end": 81}]}}, "schema": []}
{"input": "We have found that PEA2 is also required for the bipolar budding pattern and that it encodes a novel protein with a predicted coiled-coil domain.", "output": {"entities": {"gene": [{"text": "PEA2", "start": 19, "end": 23}]}}, "schema": []}
{"input": "Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway.", "output": {"entities": {"gene": [{"text": "small GTP-binding proteins Rac1", "start": 19, "end": 50}, {"text": "Cdc42", "start": 55, "end": 60}, {"text": "c-Jun N-terminal kinase", "start": 68, "end": 91}, {"text": "stress-activated protein kinase", "start": 92, "end": 123}]}}, "schema": []}
{"input": "Percent identities of the mouse PP2 to mouse Y1, mouse Y4/PP1 and human Y2 receptors are 53, 42, and 31, respectively.", "output": {"entities": {"gene": [{"text": "mouse PP2", "start": 26, "end": 35}, {"text": "mouse Y1", "start": 39, "end": 47}, {"text": "Y4", "start": 55, "end": 57}, {"text": "PP1", "start": 58, "end": 61}, {"text": "human Y2 receptors", "start": 66, "end": 84}]}}, "schema": []}
{"input": "Correlating with the previous observation that CBF binding to the 78C1 site is enhanced by EGTA and EDTA, these divalent cation chelators specifically stimulate 78C1-directed transcription.", "output": {"entities": {"gene": [{"text": "CBF", "start": 47, "end": 50}]}}, "schema": []}
{"input": "The human gene fragment ligated to the minimal rat liver glucokinase promoter was shown to work as an enhancer in the hepatocyte transfection system.", "output": {"entities": {"gene": [{"text": "glucokinase", "start": 57, "end": 68}]}}, "schema": []}
{"input": "To test the role of ML in human reproductive axis, 128 healthy children, 68 boys and 60 girls, were studied.", "output": {"entities": {}}, "schema": []}
{"input": "However, the truncated deer receptor lacks the most C-terminal tyrosine residue in the intracellular domain which is believed to be essential for activation of the beta-casein promoter.", "output": {"entities": {"gene": [{"text": "deer receptor", "start": 23, "end": 36}, {"text": "beta-casein promoter", "start": 164, "end": 184}]}}, "schema": []}
{"input": "This report provides further evidence for the riMLF in the control of downgaze, and a synkinesis is postulated for the development of the convergence retraction nystagmus.", "output": {"entities": {}}, "schema": []}
{"input": "Ninety-four percent of the EPs were tubal, and 90% of the tubes exhibited some pathologic changes, including chronic salpingitis (49. 5%) and follicular salpingitis (10%), among others.", "output": {"entities": {}}, "schema": []}
{"input": "The assessment using 7 H 9 liquid medium by the former author demonstrated the potent activities of both CS-940 * and sparfloxacin (SPFX), followed by AM-1155 *, ciprofloxacin (CPFX), levofloxacin (LVFX), OPC-17116 *, NM-394 * in sequence.", "output": {"entities": {}}, "schema": []}
{"input": "The STE20 gene, encoding a protein kinase required for pheromone signal transduction, has recently been identified in a genetic screen for high-gene-dosage suppressors of a partly defective G beta mutation.", "output": {"entities": {"gene": [{"text": "STE20 gene", "start": 4, "end": 14}, {"text": "G beta", "start": 190, "end": 196}]}}, "schema": []}
{"input": "This enzyme is designated (1--> 4)-beta-xylan endohydrolase isoenzyme X-I.", "output": {"entities": {"gene": [{"text": "(1--> 4)-beta-xylan endohydrolase isoenzyme X-I", "start": 26, "end": 73}]}}, "schema": []}
{"input": "Magnetic resonance imaging in coccidioidal arthritis.", "output": {"entities": {}}, "schema": []}
{"input": "Moloney murine leukemia virus (MMLV)-derived pUCMoTiN-based retroviral vectors were engineered to allow constitutive and Tat (trans-activator of transcription)-inducible expression of five hammerhead ribozymes targeted against highly conserved sequences within the group antigen (Gag), protease (Pro), reverse transcriptase (RT), tat, and envelope (Env) coding regions of human immunodeficiency virus type-1 (HIV-1) RNA.", "output": {"entities": {"gene": [{"text": "Tat", "start": 121, "end": 124}, {"text": "trans-activator of transcription", "start": 126, "end": 158}, {"text": "group antigen", "start": 265, "end": 278}, {"text": "Gag", "start": 280, "end": 283}, {"text": "protease", "start": 286, "end": 294}, {"text": "Pro", "start": 296, "end": 299}, {"text": "reverse transcriptase", "start": 302, "end": 323}, {"text": "RT", "start": 325, "end": 327}, {"text": "tat", "start": 330, "end": 333}, {"text": "envelope", "start": 339, "end": 347}, {"text": "Env", "start": 349, "end": 352}]}}, "schema": []}
{"input": "REM sleep deprivation was performed using the platform technique.", "output": {"entities": {}}, "schema": []}
{"input": "The same ligands also exhibit a similar inhibitory effect on PDGF-BB-dependent [3H] thymidine incorporation in PAE cells expressing the PDGF beta-receptors.", "output": {"entities": {"gene": [{"text": "PDGF-BB", "start": 61, "end": 68}, {"text": "PDGF beta-receptors", "start": 136, "end": 155}]}}, "schema": []}
{"input": "We analyzed serial biopsy specimens from eight patients with FL for secondary alterations of the rearranged bcl-2 gene in the breakpoint and open reading frame (ORF) regions.", "output": {"entities": {"gene": [{"text": "rearranged bcl-2 gene", "start": 97, "end": 118}]}}, "schema": []}
{"input": "In all eight cases, neither FL nor DLL cells showed alterations of bcl-2 gene sequences in the breakpoint region, suggesting high conservation of the bcl-2 gene during both t (14; 18) translocation and morphologic transformation of the FL cells.", "output": {"entities": {"gene": [{"text": "bcl-2 gene sequences", "start": 67, "end": 87}, {"text": "bcl-2 gene", "start": 150, "end": 160}]}}, "schema": []}
{"input": "BACKGROUND: The Bazett-corrected QT (QTc) interval during exercise has been used as a marker for ischemic disease, arrhythmogenic substrate and the long QT syndrome.", "output": {"entities": {}}, "schema": []}
{"input": "An essential role of c-Jun and c-Fos in basal and PMA-stimulated transcription of the PAI-1 gene is demonstrated by our finding that antisense c-jun and c-fos oligodeoxynucleotides both strongly reduced basal and PMA-stimulated PAI-1 synthesis.", "output": {"entities": {"gene": [{"text": "c-Jun", "start": 21, "end": 26}, {"text": "c-Fos", "start": 31, "end": 36}, {"text": "PAI-1 gene", "start": 86, "end": 96}, {"text": "c-jun", "start": 143, "end": 148}, {"text": "c-fos", "start": 153, "end": 158}, {"text": "PAI-1", "start": 228, "end": 233}]}}, "schema": []}
{"input": "To analyze the mechanism of fos/jun activation by TCDD we have used electrophoretic mobility shift and transient expression assays of reporter gene constructs containing response elements for 12-O-tetradecanoyl-phorbol-13-acetate (TRE), serum (SRE), cAMP (CRE), and aromatic hydrocarbons (AhRE) from the fos and jun genes fused to the firefly luciferase gene under the control of the SV40 minimal promoter.", "output": {"entities": {"gene": [{"text": "fos", "start": 28, "end": 31}, {"text": "jun", "start": 32, "end": 35}, {"text": "fos", "start": 304, "end": 307}, {"text": "jun genes", "start": 312, "end": 321}, {"text": "firefly luciferase gene", "start": 335, "end": 358}, {"text": "SV40 minimal promoter", "start": 384, "end": 405}]}}, "schema": []}
{"input": "The optimal sequence for interaction with mu 2 and with AP-2 has tyrosine as an anchor and prefers arginine at position Y + 2 and leucine at position Y + 3.", "output": {"entities": {"gene": [{"text": "mu 2", "start": 42, "end": 46}, {"text": "AP-2", "start": 56, "end": 60}]}}, "schema": []}
{"input": "STK/RON-expressing Ba/F3 pro-B cells (BaF/STK) exhibited MSP-dependent growth, whereas STK/RON-expressing mouse erythroleukaemia cells (MEL/STK) displayed MSP-induced apoptosis.", "output": {"entities": {"gene": [{"text": "STK", "start": 0, "end": 3}, {"text": "RON", "start": 4, "end": 7}, {"text": "STK", "start": 42, "end": 45}, {"text": "MSP", "start": 57, "end": 60}, {"text": "STK", "start": 87, "end": 90}, {"text": "RON", "start": 91, "end": 94}, {"text": "STK", "start": 140, "end": 143}, {"text": "MSP", "start": 155, "end": 158}]}}, "schema": []}
{"input": "In vitro DNase I footprinting showed that OxyR-C199S protected Pmom from-104 to-46 on the top strand and produced a protection pattern characteristic of reduced wild-type OxyR.", "output": {"entities": {"gene": [{"text": "DNase I", "start": 9, "end": 16}, {"text": "OxyR-C199S", "start": 42, "end": 52}, {"text": "Pmom", "start": 63, "end": 67}, {"text": "reduced wild-type OxyR", "start": 153, "end": 175}]}}, "schema": []}
{"input": "Kss1 binds specifically to a GST-Dig1 fusion in the absence of any other yeast protein.", "output": {"entities": {"gene": [{"text": "Kss1", "start": 0, "end": 4}, {"text": "GST", "start": 29, "end": 32}, {"text": "Dig1", "start": 33, "end": 37}]}}, "schema": []}
{"input": "In contrast, dig1 dig2 cells constitutively invade agar medium, whereas a dig1 dig2 ste12 triple mutant does not, indicating that Dig1 and Dig2 share a role in negatively regulating the invasive growth pathway.", "output": {"entities": {"gene": [{"text": "dig1 dig2", "start": 13, "end": 22}, {"text": "dig1 dig2 ste12", "start": 74, "end": 89}, {"text": "Dig1", "start": 130, "end": 134}, {"text": "Dig2", "start": 139, "end": 143}]}}, "schema": []}
{"input": "Comparison of the sequences of the xFxFG repeat regions of p62 and Nsplp indicated that NTF2 was probably interacting with the phenylalanine-containing core of these repeats and not the intervening hydrophilic linkers.", "output": {"entities": {"gene": [{"text": "p62", "start": 59, "end": 62}, {"text": "Nsplp", "start": 67, "end": 72}, {"text": "NTF2", "start": 88, "end": 92}]}}, "schema": []}
{"input": "This is the first report of the successful resection of a MFH originating in the renal capsular tissue and extending into the inferior vena cava.", "output": {"entities": {}}, "schema": []}
{"input": "Transient expression of VSF-1 in protoplasts stimulated vs-1 dependent activation of the-76/grp1. 8 minimal promoter.", "output": {"entities": {"gene": [{"text": "VSF-1", "start": 24, "end": 29}, {"text": "vs-1", "start": 56, "end": 60}, {"text": "-76/grp1. 8 minimal promoter", "start": 88, "end": 116}]}}, "schema": []}
{"input": "Keeping in mind the limited range of age and dosages, advantages and disadvantages of the drug are discussed, comparing the experimental results with those derived from the literature.", "output": {"entities": {}}, "schema": []}
{"input": "Blood sampling procedures were videotaped.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of one cDNA revealed an unusual splicing event involving EZH1 and a tandemly linked gene GPR2 and suggests a potential mechanism for modifying the EZH1 protein in the conserved C-terminal domain.", "output": {"entities": {"gene": [{"text": "EZH1", "start": 66, "end": 70}, {"text": "GPR2", "start": 98, "end": 102}, {"text": "EZH1 protein", "start": 156, "end": 168}]}}, "schema": []}
{"input": "A given standard input function and a given value of distribution volume (Vd) used for the rCBF measurement of this method were calculated from the dynamic study by six normal volunteers.", "output": {"entities": {}}, "schema": []}
{"input": "They lack a predicted single stranded (ss) DNA binding motif that is unique the large terminase proteins in T4 gp17, and that has been implicated in recognizing ssDNA regions in replicating and recombining T4DNA destined to be packaged.", "output": {"entities": {"gene": [{"text": "terminase proteins", "start": 86, "end": 104}, {"text": "T4 gp17", "start": 108, "end": 115}]}}, "schema": []}
{"input": "It can be concluded that in normotensive subjects, uric acid and xanthine oxidase have significant association with blood pressure and thus are one of the many factors which are involved in the cause or effect of hypertension.", "output": {"entities": {"gene": [{"text": "xanthine oxidase", "start": 65, "end": 81}]}}, "schema": []}
{"input": "Immunoblotting of expressed recombinant proteins with the monoclonal 08L antibody localized the 08L epitope to the carboxyl end of the protein.", "output": {"entities": {"gene": [{"text": "monoclonal 08L antibody", "start": 58, "end": 81}, {"text": "08L", "start": 96, "end": 99}]}}, "schema": []}
{"input": "We infer that the dominant negative inhibition results from both direct proteolysis of the beta-galactosidase tetramer by the fusion subunit and detour of the tetramer to the lysosome.", "output": {"entities": {"gene": [{"text": "beta-galactosidase tetramer", "start": 91, "end": 118}]}}, "schema": []}
{"input": "The current study defines the vinculin-and FAK-interaction domains on paxillin and identifies the principal paxillin focal adhesion targeting motif.", "output": {"entities": {"gene": [{"text": "vinculin", "start": 30, "end": 38}, {"text": "FAK-interaction domains", "start": 43, "end": 66}, {"text": "paxillin", "start": 70, "end": 78}, {"text": "paxillin", "start": 108, "end": 116}]}}, "schema": []}
{"input": "These data demonstrate the presence of a single binding site for vinculin, and at least two binding sites for FAK that are separated by an intervening stretch of 100 amino acids.", "output": {"entities": {"gene": [{"text": "vinculin", "start": 65, "end": 73}, {"text": "FAK", "start": 110, "end": 113}]}}, "schema": []}
{"input": "These data demonstrate that paxillin localizes to focal adhesions independent of interactions with vinculin and/or FAK, and represents the first definitive demonstration of LIM domains functioning as a primary determinant of protein subcellular localization to focal adhesions.", "output": {"entities": {"gene": [{"text": "paxillin", "start": 28, "end": 36}, {"text": "vinculin", "start": 99, "end": 107}, {"text": "FAK", "start": 115, "end": 118}, {"text": "LIM domains", "start": 173, "end": 184}]}}, "schema": []}
{"input": "A single protease-resistant structure formed by the entirety of both PDZ repeats 1 and 2 (PDZ1-2) contains the protein 4. 1-binding site.", "output": {"entities": {"gene": [{"text": "PDZ repeats 1 and 2", "start": 69, "end": 88}, {"text": "PDZ1-2", "start": 90, "end": 96}, {"text": "protein 4. 1-binding site", "start": 111, "end": 136}]}}, "schema": []}
{"input": "Several agents have been tried for treatment, often limited by toxic side effects.", "output": {"entities": {}}, "schema": []}
{"input": "Jerseys had higher hepatic Cu concentrations than did Holsteins on d 60 (346 vs.", "output": {"entities": {}}, "schema": []}
{"input": "These results are consistent with the well established polarity of RXR heterodimer binding to bipartite hormone response elements, with the VDR recognizing the 3'-half-element.", "output": {"entities": {"gene": [{"text": "RXR", "start": 67, "end": 70}, {"text": "VDR", "start": 140, "end": 143}]}}, "schema": []}
{"input": "PPAR gamma mRNA levels were reduced by 95% with 3 nM TNF alpha treatment for 24 h.", "output": {"entities": {"gene": [{"text": "PPAR gamma mRNA", "start": 0, "end": 15}, {"text": "TNF alpha", "start": 53, "end": 62}]}}, "schema": []}
{"input": "Exons III to VIII, which cover the coding region and the 3' untranslated region, are almost identical in all types of PST or AST cDNAs.", "output": {"entities": {"gene": [{"text": "PST", "start": 118, "end": 121}, {"text": "AST cDNAs", "start": 125, "end": 134}]}}, "schema": []}
{"input": "Growth factor allows effective dose-intensive regimen in advanced breast cancer patients.", "output": {"entities": {}}, "schema": []}
{"input": "Recombinant erythropoietin (r-HuEPO) in the treatment of anemia in multiple myeloma", "output": {"entities": {"gene": [{"text": "Recombinant erythropoietin", "start": 0, "end": 26}, {"text": "r-HuEPO", "start": 28, "end": 35}]}}, "schema": []}
{"input": "In 1993 and 1994 and infection with body lice was registered 41 times in 31 patients at the clinic for homeless of the Community Health Service of Utrecht.", "output": {"entities": {}}, "schema": []}
{"input": "Ki-ras and p53 mutations in pancreatic ductal adenocarcinoma.", "output": {"entities": {"gene": [{"text": "Ki-ras", "start": 0, "end": 6}, {"text": "p53 mutations", "start": 11, "end": 24}]}}, "schema": []}
{"input": "Epidemiological data are quite controversial but sudden death occurring during sporting activity is probably not a rare occurrence.", "output": {"entities": {}}, "schema": []}
{"input": "However, the ratio M/Pc provides a useful index that seems to be independent of the metabolic demand.", "output": {"entities": {}}, "schema": []}
{"input": "Rat liver catalase is sorted to peroxisomes by its C-terminal tripeptide Ala-Asn-Leu, not by the internal Ser-Lys-Leu motif.", "output": {"entities": {"gene": [{"text": "Rat liver catalase", "start": 0, "end": 18}]}}, "schema": []}
{"input": "These data provide strong evidence that E2F or an E2F-related transcription factor is involved in the regulation of nonmuscle myosin expression.", "output": {"entities": {"gene": [{"text": "E2F", "start": 40, "end": 43}, {"text": "E2F-related transcription factor", "start": 50, "end": 82}, {"text": "nonmuscle myosin", "start": 116, "end": 132}]}}, "schema": []}
{"input": "When the E1A N-terminus is used as a competitor in squelshing experiments it abolishes CBP-induced activation of E2F1/DP1, whereas an E1A mutant lacking CBP binding ability fails to do so.", "output": {"entities": {"gene": [{"text": "E1A N-terminus", "start": 9, "end": 23}, {"text": "CBP", "start": 87, "end": 90}, {"text": "E2F1", "start": 113, "end": 117}, {"text": "DP1", "start": 118, "end": 121}, {"text": "E1A mutant", "start": 134, "end": 144}, {"text": "CBP", "start": 153, "end": 156}]}}, "schema": []}
{"input": "Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1.", "output": {"entities": {"gene": [{"text": "Maf proteins", "start": 6, "end": 18}, {"text": "TCF11", "start": 64, "end": 69}, {"text": "Nrf1", "start": 70, "end": 74}, {"text": "LCR-F1", "start": 75, "end": 81}]}}, "schema": []}
{"input": "On the third occasion water (W) was ingested throughout the run.", "output": {"entities": {}}, "schema": []}
{"input": "The effect of maternal ingestion of the reduced energy sweetener erythritol was investigated in KBL: JW strain pregnant rabbits.", "output": {"entities": {}}, "schema": []}
{"input": "The nm23-H1/nm23-H2 gene transcriptional activity ratio varied depending on the cell line.", "output": {"entities": {"gene": [{"text": "nm23-H1", "start": 4, "end": 11}, {"text": "nm23-H2", "start": 12, "end": 19}]}}, "schema": []}
{"input": "CONCLUSION: Intravenous diazepam administration before EGD produces a significant fall in SpO2 during the procedure, and so should be avoided; continuous monitoring of SpO2 should be done during EGD.", "output": {"entities": {}}, "schema": []}
{"input": "The nucleotide sequence alignment between mouse and human CA IV shows 69% identity in the coding region and all of the exon-intron boundaries are conserved, as are the sizes of the introns.", "output": {"entities": {"gene": [{"text": "human CA IV", "start": 52, "end": 63}]}}, "schema": []}
{"input": "Discordance on the cost dimension correlated negatively with G Hb, suggesting better glycemic control with greater disagreement.", "output": {"entities": {"gene": [{"text": "G Hb", "start": 61, "end": 65}]}}, "schema": []}
{"input": "DATA SOURCES: Epidemiologic studies, research studies, review articles, and government reports pertaining to epidemiology of lung cancer.", "output": {"entities": {}}, "schema": []}
{"input": "Histological changes, including cortical cell involution and hemorrhage occurring during the neonatal period, would seem to have crucial relevance to the remodeling of the adrenal vasculature.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, co-expression of both p46 and p54 subunits markedly altered the subcellular distribution of p46; co-expressed p46 was transported into the nucleus as efficiently as p54.", "output": {"entities": {"gene": [{"text": "p46", "start": 35, "end": 38}, {"text": "p54 subunits", "start": 43, "end": 55}, {"text": "p46", "start": 105, "end": 108}, {"text": "p46", "start": 123, "end": 126}, {"text": "p54", "start": 178, "end": 181}]}}, "schema": []}
{"input": "The results suggest that, although both the N-and C-terminal regions of talin bind actin, the properties of these two regions of the protein are distinct.", "output": {"entities": {"gene": [{"text": "talin", "start": 72, "end": 77}, {"text": "actin", "start": 83, "end": 88}]}}, "schema": []}
{"input": "Merr.) embryo library.", "output": {"entities": {}}, "schema": []}
{"input": "The accumulation of both LHA4 and LHA2 mRNAs is induced by the addition of exogenous sugars and this induction appears to be dependent on sugar uptake and metabolism, because mannitol and 3-O-methylglucose do not stimulate mRNA accumulation.", "output": {"entities": {"gene": [{"text": "LHA4", "start": 25, "end": 29}, {"text": "LHA2 mRNAs", "start": 34, "end": 44}]}}, "schema": []}
{"input": "Using the yeast one-hybrid screen with integrated NRE and flanking DNA as bait, the predominant clone obtained was bovine Nrl.", "output": {"entities": {"gene": [{"text": "bovine Nrl", "start": 115, "end": 125}]}}, "schema": []}
{"input": "As the rate of protein synthesis decreases during late embryogenesis, levels of SEC-1 and its cognate mRNA decline precipitously.", "output": {"entities": {"gene": [{"text": "SEC-1", "start": 80, "end": 85}]}}, "schema": []}
{"input": "These findings suggest that fodrin proteolysis in vivo may reflect the activity of multiple ICE/Ced-3 proteases whose partial sensitivity to DEVD-CHO reflects a limited contribution from CPP32, or an ICE/Ced-3 protease less sensitive than CPP32 to DEVD-CHO inhibition.", "output": {"entities": {"gene": [{"text": "fodrin", "start": 28, "end": 34}, {"text": "ICE", "start": 92, "end": 95}, {"text": "Ced-3", "start": 96, "end": 101}, {"text": "CPP32", "start": 187, "end": 192}, {"text": "ICE", "start": 200, "end": 203}, {"text": "Ced-3", "start": 204, "end": 209}, {"text": "CPP32", "start": 239, "end": 244}]}}, "schema": []}
{"input": "In 3Y1 and 3Y1 v-crk-transformed fibroblasts, almost all of the total PTP1B and about 40% of total p130 (Cas) co-sediment with membranes composed primarily of endoplasmic reticulum.", "output": {"entities": {"gene": [{"text": "v-crk", "start": 15, "end": 20}, {"text": "PTP1B", "start": 70, "end": 75}, {"text": "p130", "start": 99, "end": 103}, {"text": "Cas", "start": 105, "end": 108}]}}, "schema": []}
{"input": "Replacing residues 405-419 on delta419 with the conserved AF-2 domain from the vitamin D3 receptor or the estrogen receptor results in a receptor with wild-type or low transcriptional activity, respectively.", "output": {"entities": {"gene": [{"text": "vitamin D3 receptor", "start": 79, "end": 98}, {"text": "estrogen receptor", "start": 106, "end": 123}]}}, "schema": []}
{"input": "Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines.", "output": {"entities": {"gene": [{"text": "SREBP cleavage-activating protein", "start": 51, "end": 84}]}}, "schema": []}
{"input": "The Escherichia coli tet-repressor (TetR) operator system was used to develop a variation of the yeast two-hybrid assay in which disruptions of protein-protein interactions can be identified by a positive selection.", "output": {"entities": {"gene": [{"text": "Escherichia coli tet-repressor", "start": 4, "end": 34}, {"text": "TetR", "start": 36, "end": 40}]}}, "schema": []}
{"input": "Recent studies have suggested that SHP-1 regulates the function of Jak family tyrosine kinases, as shown by its constitutive association with the Tyk2 kinase and the hyperphosphorylation of Jak kinases in the motheaten cells that lack functional SHP-1.", "output": {"entities": {"gene": [{"text": "SHP-1", "start": 35, "end": 40}, {"text": "Jak", "start": 67, "end": 70}, {"text": "tyrosine kinases", "start": 78, "end": 94}, {"text": "Tyk2 kinase", "start": 146, "end": 157}, {"text": "Jak kinases", "start": 190, "end": 201}, {"text": "SHP-1", "start": 246, "end": 251}]}}, "schema": []}
{"input": "Administration of a second dose of vaccine during the outbreak was not protective.", "output": {"entities": {}}, "schema": []}
{"input": "But, as Theriault explains, improvements in assessing exposure have not yet translated into clear and consistent findings.", "output": {"entities": {}}, "schema": []}
{"input": "Biol.", "output": {"entities": {}}, "schema": []}
{"input": "Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation.", "output": {"entities": {"gene": [{"text": "human lymphocyte kinase Lck", "start": 35, "end": 62}]}}, "schema": []}
{"input": "Evolutive morphology of the olfactory bulb in man and certain non-human mammals", "output": {"entities": {}}, "schema": []}
{"input": "From these results, we concluded that this ORF is the FRDS gene.", "output": {"entities": {"gene": [{"text": "FRDS gene", "start": 54, "end": 63}]}}, "schema": []}
{"input": "FK506 is 10-to 100-fold more potent than cyclosporin A in preventing organ rejection and in toxicity.", "output": {"entities": {}}, "schema": []}
{"input": "These results suggest that Rho1p regulates cytoskeletal reorganization at least through Bni1p and Pkc1p.", "output": {"entities": {"gene": [{"text": "Rho1p", "start": 27, "end": 32}, {"text": "Bni1p", "start": 88, "end": 93}, {"text": "Pkc1p", "start": 98, "end": 103}]}}, "schema": []}
{"input": "Waves N1, P3 and CNV were recorded during a CNV paradigm in a simple reaction time task with a constant interstimulus interval (ISI) of 1 sec.", "output": {"entities": {}}, "schema": []}
{"input": "Therefore, both the Chilean and the Japanese samples collected in high-risk areas showed higher mutagenic rates than the Japanese ones in a low-risk area, with a statistical significance (p < 0. 001), chi-square test).", "output": {"entities": {}}, "schema": []}
{"input": "Regulation of ASN1 and ASN2 expression was studied using lacZ fusions and both genes were found to be several times less expressed in the absence of the transcription activator Gcn4p.", "output": {"entities": {"gene": [{"text": "ASN1", "start": 14, "end": 18}, {"text": "ASN2", "start": 23, "end": 27}, {"text": "lacZ fusions", "start": 57, "end": 69}, {"text": "Gcn4p", "start": 177, "end": 182}]}}, "schema": []}
{"input": "Several particular features of this polypeptide fragment from the hamster lysyl-tRNA synthetase suggest that it is implicated in the assembly of that enzyme within the multisynthetase complex.", "output": {"entities": {"gene": [{"text": "hamster lysyl-tRNA synthetase", "start": 66, "end": 95}]}}, "schema": []}
{"input": "He is well, five years after relapse.", "output": {"entities": {}}, "schema": []}
{"input": "Comparison of the proportion of nonsynonymous (pN) and synonymous (pS) substitutions occurring per site within tamarin variable region genes demonstrated a reduction in pN in the framework regions compared with pN in the presumed MHC contact regions (CDR1 and CDR2).", "output": {"entities": {"gene": [{"text": "tamarin variable region genes", "start": 111, "end": 140}, {"text": "MHC contact regions", "start": 230, "end": 249}, {"text": "CDR1", "start": 251, "end": 255}, {"text": "CDR2", "start": 260, "end": 264}]}}, "schema": []}
{"input": "The effects of oral vanadyl sulfate (VOSO4) (0. 5 mg/kg/day) on anthropometry, body composition, and performance were investigated in a 12-week, double-blind, placebo-controlled trial involving weight-training volunteers.", "output": {"entities": {}}, "schema": []}
{"input": "Later in development, Tbx6 expression is restricted to presomitic, paraxial mesoderm and to the tail bud, which replaces the streak as the source of mesoderm.", "output": {"entities": {"gene": [{"text": "Tbx6", "start": 22, "end": 26}]}}, "schema": []}
{"input": "Disruption of re-replication control by overexpression of human ORC1 in fission yeast.", "output": {"entities": {"gene": [{"text": "human ORC1", "start": 58, "end": 68}]}}, "schema": []}
{"input": "Our results demonstrate that the promoter and enhancer regions identified here are essential for maintaining the efficient promoter activity of the human activin betaA subunit gene.", "output": {"entities": {"gene": [{"text": "human activin betaA subunit gene", "start": 148, "end": 180}]}}, "schema": []}
{"input": "Recombinant, bacterially expressed PIP5KIalpha possessed PIP5K activity and was immunoreactive with erythroid PIP5KI antibodies.", "output": {"entities": {"gene": [{"text": "PIP5KIalpha", "start": 35, "end": 46}, {"text": "PIP5K", "start": 57, "end": 62}, {"text": "erythroid PIP5KI antibodies", "start": 100, "end": 127}]}}, "schema": []}
{"input": "Human acid ceramidase ((AC) N-acylsphingosine amidohydrolase, EC 3. 5.", "output": {"entities": {"gene": [{"text": "Human acid ceramidase", "start": 0, "end": 21}, {"text": "(AC) N-acylsphingosine amidohydrolase", "start": 23, "end": 60}, {"text": "EC 3. 5", "start": 62, "end": 69}]}}, "schema": []}
{"input": "The 0. 22-kb NheI/BglII promoter exhibited PMA inducibility in myeloid cells and contained a PMA-responsive element recognized by Sp1 and EGR-1 transcription factors.", "output": {"entities": {"gene": [{"text": "NheI", "start": 13, "end": 17}, {"text": "BglII", "start": 18, "end": 23}, {"text": "Sp1", "start": 130, "end": 133}, {"text": "EGR-1 transcription factors", "start": 138, "end": 165}]}}, "schema": []}
{"input": "Northern (RNA) blot analyses indicated that the cdh genes encoding the five subunits and an open reading frame (ORF1) with unknown function are cotranscribed during growth on acetate.", "output": {"entities": {"gene": [{"text": "cdh genes", "start": 48, "end": 57}]}}, "schema": []}
{"input": "Two classes of mutations were obtained: (i) those that altered the coding region of HOL1, conferring the ability to take up histidinol; and (ii) cis-acting mutations (selected in a mutant HOL1-1 background) that increased expression of the Hol1 protein.", "output": {"entities": {"gene": [{"text": "HOL1", "start": 84, "end": 88}, {"text": "HOL1-1", "start": 188, "end": 194}, {"text": "Hol1 protein", "start": 240, "end": 252}]}}, "schema": []}
{"input": "Damage to the BBB was judged by extravasation of Evans Blue (EB) dye, which was administered either 2, 3, 24 or 48 h after onset of MCAo.", "output": {"entities": {}}, "schema": []}
{"input": "Lipid hydroperoxide levels in plasma and LDL remained unchanged throughout the study.", "output": {"entities": {"gene": [{"text": "LDL", "start": 41, "end": 44}]}}, "schema": []}
{"input": "We report a case of vasculitis (cutaneous and neurologic) which led to the discovery of a selective immunodeficit towards EBV, similar to Purtilo' s syndrome.", "output": {"entities": {}}, "schema": []}
{"input": "To elucidate whether potential endocrine changes resulted from acute hypoxaemia alone, the underlying disease, or unspecific influences connected with the ICU setting, all measurements were compared to those of a completely healthy reference group (REF) with comparable acute experimental hypoxaemia.", "output": {"entities": {}}, "schema": []}
{"input": "There were no significant differences in graft survival between groups with early graft function (EGF) and DGF, either in first transplantations or retransplantations.", "output": {"entities": {}}, "schema": []}
{"input": "These results suggested that the GG motifs contributed to the cell-specific transcription of the human insulin gene in association with the binding of the sequence-specific nuclear factor.", "output": {"entities": {"gene": [{"text": "human insulin gene", "start": 97, "end": 115}]}}, "schema": []}
{"input": "Abnormal urinary coproporphyrin levels in patients infected by hepatitis C virus with or without human immunodeficiency virus.", "output": {"entities": {}}, "schema": []}
{"input": "The determination of immunoglobulin E (IgE) antibodies by one of several laboratory tests, by skin-prick tests or by appropriate challenge procedures is useful either to identify atopic individuals or as outcome predictors in wheezy children.", "output": {"entities": {"gene": [{"text": "immunoglobulin E", "start": 21, "end": 37}, {"text": "IgE", "start": 39, "end": 42}]}}, "schema": []}
{"input": "Thrombosis of the renal vein may be dramatic and include renal failure.", "output": {"entities": {}}, "schema": []}
{"input": "Filter and cytocentrifuge preparations of the urine were studied and all cases displayed numerous scattered aggregates or single tumor cells in an inflammatory background.", "output": {"entities": {}}, "schema": []}
{"input": "The promoter segment was inactive when introduced into the rat glioma cell line C6B4, the rat submandibular cell line RSMT-A5, and the rat pancreatic beta cell line RIN-5AH, all of which do not express the endogenous alpha2c-AR gene.", "output": {"entities": {"gene": [{"text": "alpha2c-AR gene", "start": 217, "end": 232}]}}, "schema": []}
{"input": "The sequencing of the conditional lethal mutation ts-A13, localized in the nrdE cistron, and the lethality of insertional mutations targeted in the internal region of nrdE and nrdF, demonstrated the essential role of this locus.", "output": {"entities": {"gene": [{"text": "nrdE cistron", "start": 75, "end": 87}, {"text": "nrdE", "start": 167, "end": 171}, {"text": "nrdF", "start": 176, "end": 180}]}}, "schema": []}
{"input": "The microdensitometric scores and their side-to-side differences in patients correlated negatively with the serum 25-OHD concentration and positively with the degree of paralysis.", "output": {"entities": {}}, "schema": []}
{"input": "These data do not support the use of LDD to reduce risk of progression to MSOF in sepsis.", "output": {"entities": {}}, "schema": []}
{"input": "This correlated with reduced levels of secreted hepatitis B e antigen and increased intracellular levels of core and Pol proteins and replicative HBV DNA intermediates.", "output": {"entities": {"gene": [{"text": "hepatitis B e antigen", "start": 48, "end": 69}, {"text": "core", "start": 108, "end": 112}, {"text": "Pol proteins", "start": 117, "end": 129}]}}, "schema": []}
{"input": "In contrast, extracts of the mutant virions catalyze the wild-type level of transcription from an exogenous template containing an early promoter.", "output": {"entities": {}}, "schema": []}
{"input": "The SCMV SNE sites contain potential overlapping core recognition binding motifs for SRF, Rel/NFkappaB, ETS, and YY1 class transcription factors but fail to respond to either serum or tumor necrosis factor alpha.", "output": {"entities": {"gene": [{"text": "SCMV SNE sites", "start": 4, "end": 18}, {"text": "SRF", "start": 85, "end": 88}, {"text": "Rel", "start": 90, "end": 93}, {"text": "NFkappaB", "start": 94, "end": 102}, {"text": "ETS", "start": 104, "end": 107}, {"text": "YY1 class transcription factors", "start": 113, "end": 144}, {"text": "tumor necrosis factor alpha", "start": 184, "end": 211}]}}, "schema": []}
{"input": "Upon serum withdrawal at the permissive temperature, p53-mediated apoptosis was induced in 50 to 60% of the cells.", "output": {"entities": {"gene": [{"text": "p53", "start": 53, "end": 56}]}}, "schema": []}
{"input": "To circumvent this problem, a simple two-step strategy was devised by which essential cis-acting sites like the a sequence can be readily deleted from their natural loci in large viral DNA genomes.", "output": {"entities": {}}, "schema": []}
{"input": "On the basis of serological studies, the highly conserved A domain of HspA was found to be the immunodominant domain.", "output": {"entities": {"gene": [{"text": "HspA", "start": 70, "end": 74}]}}, "schema": []}
{"input": "In Group IV dogs that received alpha-MSH only during reperfusion, BAEPs were increased approximately 10 to 14% more than in Group II during the late reperfusion period.", "output": {"entities": {"gene": [{"text": "alpha-MSH", "start": 31, "end": 40}]}}, "schema": []}
{"input": "The Fas receptor mediates a signalling cascade resulting in programmed cell death (apoptosis) within hours of receptor cross-linking.", "output": {"entities": {"gene": [{"text": "Fas receptor", "start": 4, "end": 16}]}}, "schema": []}
{"input": "Fas has been shown to require ICE (interleukin-1 beta-converting enzyme) family proteases to induce apoptosis from studies utilizing the cowpox ICE inhibitor protein CrmA, the synthetic tetrapeptide ICE inhibitor YVAD-CMK, and the tripeptide pan-ICE inhibitor Z-VAD-FMK.", "output": {"entities": {"gene": [{"text": "Fas", "start": 0, "end": 3}, {"text": "ICE", "start": 30, "end": 33}, {"text": "interleukin-1 beta-converting enzyme", "start": 35, "end": 71}, {"text": "ICE inhibitor protein CrmA", "start": 144, "end": 170}, {"text": "ICE", "start": 199, "end": 202}, {"text": "YVAD-CMK", "start": 213, "end": 221}, {"text": "ICE", "start": 246, "end": 249}, {"text": "Z-VAD-FMK", "start": 260, "end": 269}]}}, "schema": []}
{"input": "The imprinted expression of the endogenous gene can be recapitulated in mice by using a 14-kb transgene encompassing 4 kb of 5'-flanking sequence, 8 kb of 3'-flanking sequence, which includes the two endoderm-specific enhancers, and an internally deleted structural gene.", "output": {"entities": {}}, "schema": []}
{"input": "In this report, we demonstrate that hGCN5 is also an HAT and has the same substrate specificity as yGCN5.", "output": {"entities": {"gene": [{"text": "hGCN5", "start": 36, "end": 41}, {"text": "HAT", "start": 53, "end": 56}, {"text": "yGCN5", "start": 99, "end": 104}]}}, "schema": []}
{"input": "Complementary DNAs encompassing the coat protein coding and adjacent regions of Agropyron mosaic virus (AgMV) and Hordeum mosaic virus (HoMV) were cloned and sequenced.", "output": {"entities": {"gene": [{"text": "coat protein", "start": 36, "end": 48}]}}, "schema": []}
{"input": "In some cases, factor-induced Rac activation results in Rho activation, and factor-induced Cdc42 activation leads to Rac activation, as determined by specific morphological changes.", "output": {"entities": {"gene": [{"text": "Rac", "start": 30, "end": 33}, {"text": "Rho", "start": 56, "end": 59}, {"text": "Cdc42", "start": 91, "end": 96}, {"text": "Rac", "start": 117, "end": 120}]}}, "schema": []}
{"input": "Several cDNAs corresponding to the human PWP2 gene were identified and partially sequenced.", "output": {"entities": {"gene": [{"text": "human PWP2 gene", "start": 35, "end": 50}]}}, "schema": []}
{"input": "Isolation and genomic structure of a human homolog of the yeast periodic tryptophan protein 2 (PWP2) gene mapping to 21q22. 3.", "output": {"entities": {"gene": [{"text": "yeast periodic tryptophan protein 2", "start": 58, "end": 93}, {"text": "PWP2", "start": 95, "end": 99}]}}, "schema": []}
{"input": "Patterns defined by combinations of normal and abnormal laboratory results had decreased the likelihood of PEM from an all-2 to all-0 pattern.", "output": {"entities": {}}, "schema": []}
{"input": "To examine whether thiamine (vitamin B1) deficiency is associated with recurrent aphthous stomatitis, we studied vitamin B1 levels in 70 patients with recurrent aphthous stomatitis and in 50 members of a control group.", "output": {"entities": {}}, "schema": []}
{"input": "Liver injuries", "output": {"entities": {}}, "schema": []}
{"input": "By screening a cDNA library with a probe derived from sequences downstream of the p53p2 start site, we have cloned and characterized a cDNA that represents a mRNA that appears to have been initiated from the p53p2 promoter.", "output": {"entities": {"gene": [{"text": "p53p2", "start": 82, "end": 87}, {"text": "p53p2 promoter", "start": 208, "end": 222}]}}, "schema": []}
{"input": "However, we did not observe a correlation between serum and seminal plasma PSA levels.", "output": {"entities": {"gene": [{"text": "seminal plasma PSA", "start": 60, "end": 78}]}}, "schema": []}
{"input": "The implications for estimates of cortical magnification and possible differences in the specializations of foveal and peripheral vision are discussed.", "output": {"entities": {}}, "schema": []}
{"input": "G-CSF activates multiple signaling molecules, including the JAK1 and JAK2 kinases and the STAT transcription factors.", "output": {"entities": {"gene": [{"text": "G-CSF", "start": 0, "end": 5}, {"text": "JAK1", "start": 60, "end": 64}, {"text": "JAK2 kinases", "start": 69, "end": 81}, {"text": "STAT", "start": 90, "end": 94}]}}, "schema": []}
{"input": "Mutants lacking any tyrosine residues in the cytoplasmic domain maintain their ability to activate STAT5 and STAT1 but cannot activate STAT3, implying that STAT5 and STAT1 activation does not require receptor tyrosine phosphorylation.", "output": {"entities": {"gene": [{"text": "STAT5", "start": 99, "end": 104}, {"text": "STAT1", "start": 109, "end": 114}, {"text": "STAT3", "start": 135, "end": 140}, {"text": "STAT5", "start": 156, "end": 161}, {"text": "STAT1", "start": 166, "end": 171}]}}, "schema": []}
{"input": "In addition, double mutants with either dim1-delta or dim2-1 and the endocytosis mutants end4-1 or act1-1 displayed synthetic growth defects, indicating that the DIM gene products function in a common or parallel endocytic pathway.", "output": {"entities": {"gene": [{"text": "dim1-delta", "start": 40, "end": 50}, {"text": "dim2-1", "start": 54, "end": 60}, {"text": "mutants end4-1", "start": 81, "end": 95}, {"text": "act1-1", "start": 99, "end": 105}, {"text": "DIM gene products", "start": 162, "end": 179}]}}, "schema": []}
{"input": "Such multisensory interactions can be significant for behavior.", "output": {"entities": {}}, "schema": []}
{"input": "The P13 and N22 of ppSEPs had phase reversal relationship with the P2 and N2 recorded from the PES, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "The cDNA of cpm7 encodes a closely related protein of 36. 8 kDa.", "output": {"entities": {"gene": [{"text": "cpm7", "start": 12, "end": 16}]}}, "schema": []}
{"input": "Finally, the C-terminal region of ENBP1 shows strong homology to a protein from rat that is specifically expressed in testis tissue.", "output": {"entities": {"gene": [{"text": "ENBP1", "start": 34, "end": 39}]}}, "schema": []}
{"input": "The conservation of both the G-box and H-box in different CHS promoters emphasizes their importance as regulatory motifs.", "output": {"entities": {"gene": [{"text": "CHS promoters", "start": 58, "end": 71}]}}, "schema": []}
{"input": "Mortality on the last ranch was particularly severe among certain segregated groups of turkeys that included toms, heavier birds, and birds undergoing a stressful event such as artificial insemination.", "output": {"entities": {}}, "schema": []}
{"input": "Further, the PIP2 content of the 85-90 kDa protein appeared to decrease with CSF-1 treatment.", "output": {"entities": {"gene": [{"text": "CSF-1", "start": 77, "end": 82}]}}, "schema": []}
{"input": "Further, the PIP2 content of the 85-90 kDa protein appeared to decrease with CSF-1 treatment.", "output": {"entities": {"gene": [{"text": "CSF-1", "start": 77, "end": 82}]}}, "schema": []}
{"input": "Just before inserting on the anterior margin and apex of the iliac crest it widens, assuming the aspect of a small cone.", "output": {"entities": {}}, "schema": []}
{"input": "Reperfusion caused a transient reduction in lactate production and a significant increase in LDH release.", "output": {"entities": {"gene": [{"text": "LDH", "start": 93, "end": 96}]}}, "schema": []}
{"input": "To evaluate the hepatic regenerative response in patients with alcoholic liver disease, sera from 263 patients with severe alcoholic hepatitis and/or cirrhosis were analyzed for hepatocyte growth factor (HGF) and alpha-fetoprotein (AFP).", "output": {"entities": {"gene": [{"text": "hepatocyte growth factor", "start": 178, "end": 202}, {"text": "HGF", "start": 204, "end": 207}, {"text": "alpha-fetoprotein", "start": 213, "end": 230}, {"text": "AFP", "start": 232, "end": 235}]}}, "schema": []}
{"input": "Children born from chronic alcoholic mothers have shown behavioral teratogenic effects more frequently than morphological malformations.", "output": {"entities": {}}, "schema": []}
{"input": "INTERVENTION (S): Twenty-six hemostasis parameters evaluated repeatedly in patients undergoing IVF-ET.", "output": {"entities": {}}, "schema": []}
{"input": "Here we report that expression of the I-POU/tI-POU message is maximal late in the embryonic phase of Drosophila development, and I-POU is the preferred splice variant.", "output": {"entities": {"gene": [{"text": "I-POU", "start": 38, "end": 43}, {"text": "tI-POU", "start": 44, "end": 50}, {"text": "I-POU", "start": 129, "end": 134}]}}, "schema": []}
{"input": "The patient' s role, organized by the prerequisites of expressive freedom, is counter posed with the psychoanalyst' s, which is structured to empower listening and understanding.", "output": {"entities": {}}, "schema": []}
{"input": "The most common risk factor reported for both recent and all other hepatitis C cases was a history of injecting drug use, although the proportion of cases with that history was different in NT from ACT and Queensland.", "output": {"entities": {}}, "schema": []}
{"input": "Silencing can be restored by creation of a telomere at 13 kb from the reporter construct, or by insertion of 340 bp of yeast telomeric repeat sequence at this site without chromosomal truncation.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast with previous two-pool models, provisions were made for folate turnover by urinary folate excretion (as measured here) and by fecal excretion and catabolic processes.", "output": {"entities": {}}, "schema": []}
{"input": "When voltage-operated Ca2 + channels (VOC) were blocked by nifedipine, midazolam, in concentrations more than 1 microM, attenuated both phasic and tonic responses.", "output": {"entities": {}}, "schema": []}
{"input": "Although p48 gene induction is dependent on STAT1 and JAK1, activated STAT1 does not bind to GATE.", "output": {"entities": {"gene": [{"text": "p48 gene", "start": 9, "end": 17}, {"text": "STAT1", "start": 44, "end": 49}, {"text": "JAK1", "start": 54, "end": 58}, {"text": "STAT1", "start": 70, "end": 75}, {"text": "GATE", "start": 93, "end": 97}]}}, "schema": []}
{"input": "The syndrome of resistance to thyroid hormone is characterized by elevated serum free thyroid hormones, failure to suppress pituitary thyrotropin secretion, and variable peripheral refractoriness to hormone action.", "output": {"entities": {"gene": [{"text": "pituitary thyrotropin", "start": 124, "end": 145}]}}, "schema": []}
{"input": "Finally, nonphotosynthetic mutants, including the tscA-lacking photosystem I mutant, H13, did not show evidence of light-stimulated RNA processing.", "output": {"entities": {"gene": [{"text": "tscA-lacking photosystem I mutant", "start": 50, "end": 83}]}}, "schema": []}
{"input": "The progression of acute bronchitis is associated with elevated blood concentrations of acute-phase proteins, KKS activation in the blood and high serotonin and lactic acid content in the humor condensated from the exhaled air.", "output": {"entities": {"gene": [{"text": "KKS", "start": 110, "end": 113}]}}, "schema": []}
{"input": "Because of the potential implications of these findings in human physiology, we cloned the hPACAP-R gene.", "output": {"entities": {"gene": [{"text": "hPACAP-R gene", "start": 91, "end": 104}]}}, "schema": []}
{"input": "Differential signaling and immediate-early gene activation by four splice variants of the human pituitary adenylate cyclase-activating polypeptide receptor (hPACAP-R).", "output": {"entities": {"gene": [{"text": "immediate-early gene", "start": 27, "end": 47}, {"text": "human pituitary adenylate cyclase-activating polypeptide receptor", "start": 90, "end": 155}, {"text": "hPACAP-R", "start": 157, "end": 165}]}}, "schema": []}
{"input": "We discuss these results with respect to the transcriptional induction of the HNF-3 alpha gene in respiratory epithelium during embryogenesis.", "output": {"entities": {"gene": [{"text": "HNF-3 alpha gene", "start": 78, "end": 94}]}}, "schema": []}
{"input": "BACKGROUND: Mitosis is regulated by MPF (maturation promoting factor), the active form of Cdc2/28-cyclin B complexes.", "output": {"entities": {"gene": [{"text": "MPF", "start": 36, "end": 39}, {"text": "maturation promoting factor", "start": 41, "end": 68}, {"text": "Cdc2/28", "start": 90, "end": 97}, {"text": "cyclin B", "start": 98, "end": 106}]}}, "schema": []}
{"input": "Ectopic expression of Apo-3 in HEK293 or HeLa cells induced marked apoptosis.", "output": {"entities": {"gene": [{"text": "Apo-3", "start": 22, "end": 27}]}}, "schema": []}
{"input": "An N-terminal arm from each subunit wraps around the dinucleotide-binding domain of an adjacent subunit, covering the adenine ring of NADP.", "output": {"entities": {}}, "schema": []}
{"input": "Similarity is most striking in the zinc knuckle region, a region characteristic of gag genes of most replication-competent retroelements.", "output": {"entities": {"gene": [{"text": "gag genes", "start": 83, "end": 92}]}}, "schema": []}
{"input": "D. melanogaster HeT-A coding sequences have a polymorphic region with insertions/deletions of 1-31 codons and many nucleotide changes.", "output": {"entities": {"gene": [{"text": "HeT-A", "start": 16, "end": 21}]}}, "schema": []}
{"input": "Eukaryotic initiation factor 3 (eIF3) is a large multisubunit complex that stabilizes the ternary complex, eIF2 x GTP x tRNA (Met) i and promotes mRNA binding to the 40 S ribosomal subunit. eIF3 also functions as a ribosome subunit anti-association factor.", "output": {"entities": {"gene": [{"text": "Eukaryotic initiation factor 3", "start": 0, "end": 30}, {"text": "eIF3", "start": 32, "end": 36}, {"text": "eIF2", "start": 107, "end": 111}, {"text": "tRNA (Met) i", "start": 120, "end": 132}, {"text": "40 S ribosomal subunit", "start": 166, "end": 188}, {"text": "eIF3", "start": 190, "end": 194}]}}, "schema": []}
{"input": "Our data, combined with those of Hershey and co-workers, suggest that mammalian eIF3 is composed of at least 10 subunits: p170, p116 (hPrt1), p110, p66, p48, p47, p44, p40, p36, and p35.", "output": {"entities": {"gene": [{"text": "mammalian eIF3", "start": 70, "end": 84}, {"text": "p170", "start": 122, "end": 126}, {"text": "p116", "start": 128, "end": 132}, {"text": "hPrt1", "start": 134, "end": 139}, {"text": "p110", "start": 142, "end": 146}, {"text": "p66", "start": 148, "end": 151}, {"text": "p48", "start": 153, "end": 156}, {"text": "p47", "start": 158, "end": 161}, {"text": "p44", "start": 163, "end": 166}, {"text": "p40", "start": 168, "end": 171}, {"text": "p36", "start": 173, "end": 176}, {"text": "p35", "start": 182, "end": 185}]}}, "schema": []}
{"input": "Identification of a cis-acting element in the class I major histocompatibility complex gene promoter responsive to activation by retroviral sequences.", "output": {"entities": {"gene": [{"text": "class I major histocompatibility complex gene promoter", "start": 46, "end": 100}]}}, "schema": []}
{"input": "The results demonstrate that (i) no intact capsids were assembled when the full-length or a truncated (missing the C-terminal 65 amino acids) UL80. 5 protein was tested; (ii) when the C-terminal 65 amino acids of the UL80. 5 protein were replaced with the C-terminal 25 amino acids of the UL26. 5 protein, intact capsids were made and direct interaction of the UL80. 5 protein with VP5 was detected; (iii) assembly of intact capsids was demonstrated when the sequence of the last 12 amino acids of the UL80. 5 protein was changed from RRIFVA ALNKLE to RRIFVAAMMKLE; (iv) self-interaction of the scaffold proteins is mediated by sequences N terminal to the maturation cleavage site; and (v) the UL26. 5 and UL80. 5 proteins will not coassemble into scaffold structures.", "output": {"entities": {"gene": [{"text": "UL80. 5 protein", "start": 142, "end": 157}, {"text": "UL80. 5 protein", "start": 217, "end": 232}, {"text": "UL26. 5 protein", "start": 289, "end": 304}, {"text": "UL80. 5 protein", "start": 361, "end": 376}, {"text": "VP5", "start": 382, "end": 385}, {"text": "UL80. 5 protein", "start": 502, "end": 517}, {"text": "UL26. 5", "start": 694, "end": 701}, {"text": "UL80. 5 proteins", "start": 706, "end": 722}]}}, "schema": []}
{"input": "Fourth, the 3'-region splice junctions of the MSRs during latent and productive infection were determined by sequencing RNA-PCR products generated with primers that flank the 3' splice region.", "output": {"entities": {"gene": [{"text": "MSRs", "start": 46, "end": 50}]}}, "schema": []}
{"input": "(ii) ICP27 binds preferentially to less modified forms of ICP4, a protein that is extensively modified posttranslationally.", "output": {"entities": {"gene": [{"text": "ICP27", "start": 5, "end": 10}, {"text": "ICP4", "start": 58, "end": 62}]}}, "schema": []}
{"input": "Lack of sufficient data on vibration measurements and employment durations add to the uncertainty, as do variations in tool conditions (grinder wheels, etc) and inherent difficulties in measurement.", "output": {"entities": {}}, "schema": []}
{"input": "C/EBP beta V > A selectively binds only the subset of C/EBP sites that are also DBP sites, both as oligonucleotides and within the natural contexts of the albumin and cholesterol hydroxylase promoters.", "output": {"entities": {"gene": [{"text": "C/EBP beta V", "start": 0, "end": 12}, {"text": "C/EBP sites", "start": 54, "end": 65}, {"text": "DBP sites", "start": 80, "end": 89}, {"text": "albumin", "start": 155, "end": 162}, {"text": "cholesterol hydroxylase promoters", "start": 167, "end": 200}]}}, "schema": []}
{"input": "Specific IgG, specific IgE and total IgE immunoglobulins against Toxocara canis excretory/secretory antigens (TES) were detected by using ELISA technique.", "output": {"entities": {"gene": [{"text": "IgG", "start": 9, "end": 12}, {"text": "IgE", "start": 23, "end": 26}, {"text": "IgE immunoglobulins", "start": 37, "end": 56}, {"text": "Toxocara canis excretory/secretory antigens", "start": 65, "end": 108}, {"text": "TES", "start": 110, "end": 113}]}}, "schema": []}
{"input": "SUMMARY BACKGROUND DATA: Melanoma care has not changed significantly in the last 20 years, and the controversy of elective lymph node dissections in this disease continues to be discussed.", "output": {"entities": {}}, "schema": []}
{"input": "The differences among subgenera of the genus Dermacentor are more significant.", "output": {"entities": {}}, "schema": []}
{"input": "Mutating the E-box in the context of the 3'-flanking region confirmed that it contributes to the enhancement of transcriptional activity of the alpha1 (I) collagen gene promoter.", "output": {"entities": {"gene": [{"text": "alpha1 (I) collagen gene promoter", "start": 144, "end": 177}]}}, "schema": []}
{"input": "Expression of neuronal traits in pancreatic beta cells.", "output": {"entities": {}}, "schema": []}
{"input": "We propose that Mnt: Max: Sin3 complexes normally function to restrict Myc: Max activities associated with cell proliferation.", "output": {"entities": {"gene": [{"text": "Mnt", "start": 16, "end": 19}, {"text": "Max", "start": 21, "end": 24}, {"text": "Sin3", "start": 26, "end": 30}, {"text": "Myc", "start": 71, "end": 74}, {"text": "Max", "start": 76, "end": 79}]}}, "schema": []}
{"input": "Phenotypic changes induced by wild type and variant c-src genes carrying C-terminal sequence alterations.", "output": {"entities": {"gene": [{"text": "wild type and variant c-src genes", "start": 30, "end": 63}]}}, "schema": []}
{"input": "The resurgence of drug-resistant malaria makes urgent the evaluation of new antimalarial agents.", "output": {"entities": {}}, "schema": []}
{"input": "In the p51 subunit, the Cys181 side-chain is oriented in a similar direction to the Tyr181 side-chain in the wild-type complex.", "output": {"entities": {"gene": [{"text": "p51 subunit", "start": 7, "end": 18}]}}, "schema": []}
{"input": "The relatively high level transcription from this gene shows that the polymorphic chromosome ends of P. falciparum, which have been proposed to be transcriptionally silent, can be active expression sites for var genes.", "output": {"entities": {"gene": [{"text": "var genes", "start": 208, "end": 217}]}}, "schema": []}
{"input": "NUP145 was previously identified by using a genetic synthetic lethal screen (E.", "output": {"entities": {"gene": [{"text": "NUP145", "start": 0, "end": 6}]}}, "schema": []}
{"input": "Prevalence of sleep-disordered breathing (SDB) is reported to increase in menopausal women.", "output": {"entities": {}}, "schema": []}
{"input": "In all cases the antigenemia was transient and cleared by 28th day post-vaccination.", "output": {"entities": {}}, "schema": []}
{"input": "A total of 1459 men aged 48 to 84 years, who were diagnosed for the first time by physicians as having BPH in 1994 and who had not received treatment, participated in the study.", "output": {"entities": {}}, "schema": []}
{"input": "In vitro translation of the mTRF1 cDNA resulted in a 56 kDa protein that binds to TTAGGG repeat arrays. mTRF1 displayed the same sequence specificity as hTRF1, preferring arrays of TTAGGG repeats as a binding substrate over TTAGGC and TTGGGG repeats.", "output": {"entities": {"gene": [{"text": "mTRF1 cDNA", "start": 28, "end": 38}, {"text": "mTRF1", "start": 104, "end": 109}, {"text": "hTRF1", "start": 153, "end": 158}]}}, "schema": []}
{"input": "The ubiquitously expressed E12 bHLH protein dimerizes with numerous cell-specific bHLH factors.", "output": {"entities": {"gene": [{"text": "E12 bHLH protein", "start": 27, "end": 43}, {"text": "bHLH factors", "start": 82, "end": 94}]}}, "schema": []}
{"input": "The E-box sequence in the SE2 fragment of the transferrin promoter was CATCTG and was similar in gel shifts to the consensus E-box elements (CANNTG) previously characterized.", "output": {"entities": {"gene": [{"text": "SE2 fragment", "start": 26, "end": 38}, {"text": "transferrin promoter", "start": 46, "end": 66}]}}, "schema": []}
{"input": "A 5. 3-kb DNA fragment, which included the entire structural porin gene (named porCa) and its flanking regions, was identified.", "output": {"entities": {"gene": [{"text": "porin gene", "start": 61, "end": 71}, {"text": "porCa", "start": 79, "end": 84}]}}, "schema": []}
{"input": "The human p100 protein was recently identified as a coactivator of the Epstein-Barr virus nuclear antigen 2.", "output": {"entities": {"gene": [{"text": "human p100 protein", "start": 4, "end": 22}, {"text": "Epstein-Barr virus nuclear antigen 2", "start": 71, "end": 107}]}}, "schema": []}
{"input": "However, five new mutation sites (S61, SL1, S29, SL11, SL196 and SL126) are unique to the nrdB intron and disrupt self-splicing.", "output": {"entities": {"gene": [{"text": "S61", "start": 34, "end": 37}, {"text": "SL1", "start": 39, "end": 42}, {"text": "S29", "start": 44, "end": 47}, {"text": "SL11", "start": 49, "end": 53}, {"text": "SL196", "start": 55, "end": 60}, {"text": "SL126", "start": 65, "end": 70}, {"text": "nrdB", "start": 90, "end": 94}]}}, "schema": []}
{"input": "This report presents the isolation and characterization of the 5'-flanking region (1. 2 kb) and exon 1 of the human RII alpha gene.", "output": {"entities": {"gene": [{"text": "human RII alpha gene", "start": 110, "end": 130}]}}, "schema": []}
{"input": "A cohort of Swedish children was monitored from 6 months to 11 years of age.", "output": {"entities": {}}, "schema": []}
{"input": "The aim of this study was to assess the reproducibility of a number of simplified clearance methods using chromium-51 ethylenediamine tetraacetic acid (51Cr-EDTA) and to compare these with the multiple blood sample technique.", "output": {"entities": {}}, "schema": []}
{"input": "The primary structure of a 2671 bp DNA fragment between the pla gene (encoding plasminogen activator) and the origin of replication of the wild-type Yersinia pestis plasmid pYP358 was determined.", "output": {"entities": {"gene": [{"text": "pla gene", "start": 60, "end": 68}, {"text": "plasminogen activator", "start": 79, "end": 100}]}}, "schema": []}
{"input": "MAIN OUTCOME MEASURES: Associations of factor analysis-derived syndromes with risk factors for chemical interactions that inhibit butyrylcholinesterase and neuropathy target esterase.", "output": {"entities": {"gene": [{"text": "butyrylcholinesterase", "start": 130, "end": 151}, {"text": "esterase", "start": 174, "end": 182}]}}, "schema": []}
{"input": "CONCLUSION: Some Gulf War veterans may have delayed, chronic neurotoxic syndromes from wartime exposure to combinations of chemicals that inhibit butyrylcholinesterase and neuropathy target esterase.", "output": {"entities": {"gene": [{"text": "butyrylcholinesterase", "start": 146, "end": 167}, {"text": "neuropathy target esterase", "start": 172, "end": 198}]}}, "schema": []}
{"input": "No correlation between the age of the horses and the antibody level could be found.", "output": {"entities": {}}, "schema": []}
{"input": "The GHR mRNA: GHBP mRNA ratio was 1. 1 +/-0. 12 and remained unchanged during differentiation.", "output": {"entities": {"gene": [{"text": "GHR mRNA", "start": 4, "end": 12}, {"text": "GHBP mRNA", "start": 14, "end": 23}]}}, "schema": []}
{"input": "The results demonstrate (i) that the selenocysteine-specific UGA codon is readily suppressed under conditions where the homologous SelB protein is absent and (ii) that apart from the specificity of the SelB-mRNA interaction, a structural compatibility of the quaternary complex with the ribosome is required.", "output": {"entities": {"gene": [{"text": "homologous SelB protein", "start": 120, "end": 143}, {"text": "SelB-mRNA", "start": 202, "end": 211}]}}, "schema": []}
{"input": "One linker-peptide insertion in the RsaA C terminus (amino acid 784) had no effect on S-layer biogenesis, while another (amino acid 907) disrupted secretion of the protein, suggesting that RsaA possesses a secretion signal lying C terminal to amino acid 784, near or including amino acid 907.", "output": {"entities": {"gene": [{"text": "RsaA C terminus (amino acid 784)", "start": 36, "end": 68}, {"text": "RsaA", "start": 189, "end": 193}]}}, "schema": []}
{"input": "To characterize the gene products, the cvaA gene was subcloned and expressed under the control of T7 RNA polymerase promoter.", "output": {"entities": {"gene": [{"text": "cvaA gene", "start": 39, "end": 48}, {"text": "T7 RNA polymerase promoter", "start": 98, "end": 124}]}}, "schema": []}
{"input": "PrpB showed homology to carboxyphosphonoenolpyruvate phosphonomutase of Streptomyces hygroscopicus and to its homolog in the carnation Dianthus caryophyllus; PrpC was homologous to both archaeal and bacterial citrate synthases; PrpD showed homology to yeast and Bacillus subtilis proteins of unknown function; PrpE showed homology to acetyl coenzyme A synthetases.", "output": {"entities": {"gene": [{"text": "PrpB", "start": 0, "end": 4}, {"text": "carboxyphosphonoenolpyruvate phosphonomutase of Streptomyces hygroscopicus", "start": 24, "end": 98}, {"text": "PrpC", "start": 158, "end": 162}, {"text": "archaeal and bacterial citrate synthases", "start": 186, "end": 226}, {"text": "PrpD", "start": 228, "end": 232}, {"text": "PrpE", "start": 310, "end": 314}, {"text": "acetyl coenzyme A synthetases", "start": 334, "end": 363}]}}, "schema": []}
{"input": "MAIN OUTCOME MEASURES: Systemic and pulmonary hemodynamics, arterial blood gas determination, bronchoalveolar lavage protein and neutrophil content, neutrophil oxidant burst, lung myeloperoxidase content, and scanning electron micrographic studies.", "output": {"entities": {"gene": [{"text": "lung myeloperoxidase", "start": 175, "end": 195}]}}, "schema": []}
{"input": "We have isolated a cDNA encoding human MEKK3.", "output": {"entities": {"gene": [{"text": "human MEKK3", "start": 33, "end": 44}]}}, "schema": []}
{"input": "To investigate the mechanisms involved in the transcriptional control of retinoid X receptor (RXR) gene expression, the 5'-flanking region of the human RXRgamma2 isoform was characterized.", "output": {"entities": {"gene": [{"text": "retinoid X receptor", "start": 73, "end": 92}, {"text": "RXR", "start": 94, "end": 97}, {"text": "human RXRgamma2 isoform", "start": 146, "end": 169}]}}, "schema": []}
{"input": "JNK and p38 are constitutively present in the nucleus, and DNA-bound c-JUN and ATF-2 are stably contacted by JNK and p38, respectively.", "output": {"entities": {"gene": [{"text": "JNK", "start": 0, "end": 3}, {"text": "p38", "start": 8, "end": 11}, {"text": "c-JUN", "start": 69, "end": 74}, {"text": "ATF-2", "start": 79, "end": 84}, {"text": "JNK", "start": 109, "end": 112}, {"text": "p38", "start": 117, "end": 120}]}}, "schema": []}
{"input": "The effects of dominant interfering forms of the JNK/p38 signaling pathway demonstrate that activation of these kinases is critical for cytokine-induced E-selectin gene expression.", "output": {"entities": {"gene": [{"text": "JNK", "start": 49, "end": 52}, {"text": "p38", "start": 53, "end": 56}, {"text": "E-selectin gene", "start": 153, "end": 168}]}}, "schema": []}
{"input": "Sp1 binds the CTC repeat with an affinity, KD = 0. 37 nM, at least as high as the consensus GC box.", "output": {"entities": {"gene": [{"text": "Sp1", "start": 0, "end": 3}]}}, "schema": []}
{"input": "Identification of the region in actin-binding protein that binds to the cytoplasmic domain of glycoprotein IBalpha.", "output": {"entities": {"gene": [{"text": "actin-binding protein", "start": 32, "end": 53}, {"text": "glycoprotein IBalpha", "start": 94, "end": 114}]}}, "schema": []}
{"input": "Mutant enzyme forms were prepared to eliminate the initial autoprocessing site and thus form an active single-chain protein for structure-function studies.", "output": {"entities": {}}, "schema": []}
{"input": "The primer is generated by a cleavage that occurs between bases 11 and 12 of the Tf1 mRNA.", "output": {"entities": {"gene": [{"text": "Tf1 mRNA", "start": 81, "end": 89}]}}, "schema": []}
{"input": "Similarly, we examined whether the ELK1, SAP1a, FLI1, EWS-FLI1, ETS1, ETS2, PEA3 and PU. 1 proteins can form ternary complexes with SRF on the Egr1 SREI and II.", "output": {"entities": {"gene": [{"text": "ELK1", "start": 35, "end": 39}, {"text": "SAP1a", "start": 41, "end": 46}, {"text": "FLI1", "start": 48, "end": 52}, {"text": "EWS", "start": 54, "end": 57}, {"text": "FLI1", "start": 58, "end": 62}, {"text": "ETS1", "start": 64, "end": 68}, {"text": "ETS2", "start": 70, "end": 74}, {"text": "PEA3", "start": 76, "end": 80}, {"text": "PU. 1 proteins", "start": 85, "end": 99}, {"text": "SRF", "start": 132, "end": 135}, {"text": "Egr1 SREI and II", "start": 143, "end": 159}]}}, "schema": []}
{"input": "This R-domain may modulate the interaction with SRF, providing a mechanism that would be unique to FLI1 and EWS-FLI1, thus implicating a novel function for these ETS transcription factors in the regulation of the Egr1 gene.", "output": {"entities": {"gene": [{"text": "SRF", "start": 48, "end": 51}, {"text": "FLI1", "start": 99, "end": 103}, {"text": "EWS", "start": 108, "end": 111}, {"text": "FLI1", "start": 112, "end": 116}, {"text": "ETS transcription factors", "start": 162, "end": 187}, {"text": "Egr1 gene", "start": 213, "end": 222}]}}, "schema": []}
{"input": "The murine chromosomal locations of the five NMDA receptor channel subunits, the epsilon 1 (Grin2a), epsilon 2 (Grin2b), epsilon 3 (Grin2c), epsilon 4 (Grin2d) and zeta 1 (Grinl) subunits, were determined using an interspecific backcross mapping panel derived from crosses of [(C57BL/6JxM. spretus) F1xC57BL/6J] mice.", "output": {"entities": {"gene": [{"text": "NMDA receptor channel subunits", "start": 45, "end": 75}, {"text": "epsilon 1", "start": 81, "end": 90}, {"text": "Grin2a", "start": 92, "end": 98}, {"text": "epsilon 2", "start": 101, "end": 110}, {"text": "Grin2b", "start": 112, "end": 118}, {"text": "epsilon 3", "start": 121, "end": 130}, {"text": "Grin2c", "start": 132, "end": 138}, {"text": "epsilon 4", "start": 141, "end": 150}, {"text": "Grin2d", "start": 152, "end": 158}, {"text": "zeta 1", "start": 164, "end": 170}, {"text": "Grinl", "start": 172, "end": 177}]}}, "schema": []}
{"input": "CDNA cloning of chick brain alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors reveals conservation of structure, function and post-transcriptional processes with mammalian receptors.", "output": {"entities": {"gene": [{"text": "chick brain alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors", "start": 16, "end": 94}]}}, "schema": []}
{"input": "Remarkably, both TTD-A and XP-D defects are associated with subunits of TFIIH, a basal transcription factor with a second function in DNA repair.", "output": {"entities": {"gene": [{"text": "TFIIH", "start": 72, "end": 77}]}}, "schema": []}
{"input": "Adjustment for age, total cholesterol, HDL cholesterol, triglycerides, current smoking, and systolic pressure slightly reduced the association between fibrinogen and atherosclerosis.", "output": {"entities": {"gene": [{"text": "HDL cholesterol", "start": 39, "end": 54}, {"text": "fibrinogen", "start": 151, "end": 161}]}}, "schema": []}
{"input": "Cholesterol side-chain cleavage cytochrome P450 (CYP11A; P450scc) gene expression is regulated by gonadotropins via cAMP in the ovary and by ACTH via cAMP in adrenal cortical cells.", "output": {"entities": {"gene": [{"text": "Cholesterol side-chain cleavage cytochrome P450", "start": 0, "end": 47}, {"text": "CYP11A", "start": 49, "end": 55}, {"text": "P450scc", "start": 57, "end": 64}, {"text": "gonadotropins", "start": 98, "end": 111}, {"text": "ACTH", "start": 141, "end": 145}]}}, "schema": []}
{"input": "One possible solution is a thin radial forearm free flap.", "output": {"entities": {}}, "schema": []}
{"input": "Structural analysis and characterization of tissue and hormonal responsive expression of the avian bone sialoprotein (BSP) gene.", "output": {"entities": {"gene": [{"text": "avian bone sialoprotein", "start": 93, "end": 116}, {"text": "BSP", "start": 118, "end": 121}]}}, "schema": []}
{"input": "The Y-type structural motif is also conserved among a number of divergent BiP mRNAs.", "output": {"entities": {"gene": [{"text": "BiP mRNAs", "start": 74, "end": 83}]}}, "schema": []}
{"input": "A false positive marker screen was associated with the occurrence of hand-foot syndrome even when the effect of regimen was accounted for by stratification (p =. 01).", "output": {"entities": {}}, "schema": []}
{"input": "The detection of ORF-1 sequences in human tumors, while not proof per se, is a prerequisite for establishing its role in tumor development.", "output": {"entities": {"gene": [{"text": "ORF-1", "start": 17, "end": 22}]}}, "schema": []}
{"input": "Phylogenetic analysis gave evidence for a close evolutionary relationship between PhHV-1 and members of the Varicellovirus genus of the alpha-Herpesvirinae and canid herpesvirus in particular.", "output": {"entities": {}}, "schema": []}
{"input": "In this method, PLP in plasma can be determined with high sensitivity using derivatization with sodium bisulfite in the mobile phase.", "output": {"entities": {}}, "schema": []}
{"input": "Both HEF1 and Cas were found to complex with the related adhesion focal tyrosine kinase (RAFTK), and when tyrosine phosphorylated, with the adapter molecule CrkL.", "output": {"entities": {"gene": [{"text": "HEF1", "start": 5, "end": 9}, {"text": "Cas", "start": 14, "end": 17}, {"text": "related adhesion focal tyrosine kinase", "start": 49, "end": 87}, {"text": "RAFTK", "start": 89, "end": 94}, {"text": "CrkL", "start": 157, "end": 161}]}}, "schema": []}
{"input": "SIM1 and SIM2 do not form homodimers, and they do not interact with AHR.", "output": {"entities": {"gene": [{"text": "SIM1", "start": 0, "end": 4}, {"text": "SIM2", "start": 9, "end": 13}, {"text": "AHR", "start": 68, "end": 71}]}}, "schema": []}
{"input": "Complexes of qTBP42 with each complementary strand of telomeric DNA and with quadruplex forms of the guanine-rich strand had 3. 7-14. 6 nM dissociation constants, Kd, whereas complexes with double-stranded telomeric DNA had up to 100-fold higher Kd values.", "output": {"entities": {"gene": [{"text": "qTBP42", "start": 13, "end": 19}]}}, "schema": []}
{"input": "Moreover, the effect exerted by TIS1 appeared to be selective for the MCK promoter.", "output": {"entities": {"gene": [{"text": "TIS1", "start": 32, "end": 36}, {"text": "MCK promoter", "start": 70, "end": 82}]}}, "schema": []}
{"input": "What' s new in gynecologic and obstetrical surgery.", "output": {"entities": {}}, "schema": []}
{"input": "The dnaK operon of Bacillus subtilis is heptacistronic.", "output": {"entities": {"gene": [{"text": "dnaK operon of Bacillus subtilis", "start": 4, "end": 36}]}}, "schema": []}
{"input": "Moreover, expression of CBF1 in yeast was found to activate transcription of reporter genes containing the C-repeat/DRE as an upstream activator sequence but not mutant versions of the DNA element.", "output": {"entities": {"gene": [{"text": "CBF1", "start": 24, "end": 28}]}}, "schema": []}
{"input": "Forty-one ASA physical status I or II adult patients undergoing a variety of 1-1. 5 h surgical procedures were randomly allocated to receive CCA with desflurane or isoflurane with ventilation being either spontaneous or controlled.", "output": {"entities": {}}, "schema": []}
{"input": "OBJECTIVE: Our goal was to determine whether chlamydia-infected women have a higher rate of febrile complications after postpartum tubal ligation.", "output": {"entities": {}}, "schema": []}
{"input": "In the electrophoresis mobility shift assay using nuclear extracts of the myogenic cells, MyoD and myogenin bound to the right E-box in the enhancer region of the MCK gene even in the presence of BMP-2.", "output": {"entities": {"gene": [{"text": "MyoD", "start": 90, "end": 94}, {"text": "myogenin", "start": 99, "end": 107}, {"text": "MCK gene", "start": 163, "end": 171}, {"text": "BMP-2", "start": 196, "end": 201}]}}, "schema": []}
{"input": "A heterologous promoter construct containing three repeats of a consensus Sp1 site, cloned upstream of a single copy of the ZII (CREB/AP1) element from the BZLF1 promoter linked to the beta-globin TATA box, exhibited phorbol ester inducibility.", "output": {"entities": {"gene": [{"text": "Sp1 site", "start": 74, "end": 82}, {"text": "ZII", "start": 124, "end": 127}, {"text": "CREB/AP1", "start": 129, "end": 137}, {"text": "BZLF1 promoter", "start": 156, "end": 170}, {"text": "beta-globin", "start": 185, "end": 196}]}}, "schema": []}
{"input": "Subsequent experiments showed that motoric tasks rather than cognitive aspects of the COWA task were critical in potentiating finger-tapping performance.", "output": {"entities": {}}, "schema": []}
{"input": "cDNA cloning, expression analysis, and chromosomal localization of a gene with high homology to wheat eIF-(iso) 4F and mammalian eIF-4G.", "output": {"entities": {"gene": [{"text": "wheat eIF-(iso) 4F", "start": 96, "end": 114}, {"text": "mammalian eIF-4G", "start": 119, "end": 135}]}}, "schema": []}
{"input": "Therefore, it is important to control hypertension and keep appropriate renal blood flow during living renal transplantation surgery.", "output": {"entities": {}}, "schema": []}
{"input": "The initial patients treated with AZQ and mitroxantrone experienced prolonged bone marrow suppression and, therefore, subsequent cohorts were treated with G-CSF, 5 micrograms/kg, beginning the day after completion of the third cycle of chemotherapy.", "output": {"entities": {"gene": [{"text": "G-CSF", "start": 155, "end": 160}]}}, "schema": []}
{"input": "Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) activates a set of genes such as c-fos, jun, myc, and early growth response gene 1 (egr-1).", "output": {"entities": {"gene": [{"text": "Human granulocyte-macrophage colony-stimulating factor", "start": 0, "end": 54}, {"text": "hGM-CSF", "start": 56, "end": 63}, {"text": "c-fos", "start": 98, "end": 103}, {"text": "jun", "start": 105, "end": 108}, {"text": "myc", "start": 110, "end": 113}, {"text": "early growth response gene 1", "start": 119, "end": 147}, {"text": "egr-1", "start": 149, "end": 154}]}}, "schema": []}
{"input": "In order to provide adequate local control without compromising cosmetic outcome, the amount of breast tissue that must be excised in BCT needs to be individualized.", "output": {"entities": {}}, "schema": []}
{"input": "Surprisingly, however, TCR-mediated tyrosine phosphorylation of phospholipase C gamma 1 remains intact in the Jurkat cells expressing the A2/HCP chimera.", "output": {"entities": {"gene": [{"text": "TCR", "start": 23, "end": 26}, {"text": "phospholipase C gamma 1", "start": 64, "end": 87}, {"text": "A2", "start": 138, "end": 140}, {"text": "HCP", "start": 141, "end": 144}]}}, "schema": []}
{"input": "The 14. 1 (IGLL1) gene is expressed in a lineage-and stage-restricted manner.", "output": {"entities": {"gene": [{"text": "14. 1 (IGLL1) gene", "start": 4, "end": 22}]}}, "schema": []}
{"input": "The interferon (IFN)-induced double-stranded RNA (dsRNA)-activated Ser/Thr protein kinase (PKR) plays a role in the antiviral and antiproliferative effects of IFN.", "output": {"entities": {"gene": [{"text": "interferon", "start": 4, "end": 14}, {"text": "IFN", "start": 16, "end": 19}, {"text": "double-stranded RNA (dsRNA)-activated Ser/Thr protein kinase", "start": 29, "end": 89}, {"text": "PKR", "start": 91, "end": 94}, {"text": "IFN", "start": 159, "end": 162}]}}, "schema": []}
{"input": "Together, the data suggest that cAMP-dependent control of the amounts of the activator SF-1 vs. the repressor COUP-TF could influence CRS2-dependent transcription.", "output": {"entities": {"gene": [{"text": "SF-1", "start": 87, "end": 91}, {"text": "COUP-TF", "start": 110, "end": 117}]}}, "schema": []}
{"input": "Object relations, affect management, and psychic structure formation.", "output": {"entities": {}}, "schema": []}
{"input": "When expressed in COS-7 cells, MKP-4 blocks activation of MAP kinases with the selectivity ERK > p38 = JNK/SAPK.", "output": {"entities": {"gene": [{"text": "MKP-4", "start": 31, "end": 36}, {"text": "MAP kinases", "start": 58, "end": 69}, {"text": "ERK", "start": 91, "end": 94}, {"text": "p38", "start": 97, "end": 100}, {"text": "JNK", "start": 103, "end": 106}, {"text": "SAPK", "start": 107, "end": 111}]}}, "schema": []}
{"input": "Most kinases are not significantly inhibited by roscovitine. cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E and cdk5/p35 only are substantially inhibited (IC50 values of 0. 65, 0. 7, 0. 7 and 0. 2 microM, respectively). cdk4/cyclin D1 and cdk6/cyclin D2 are very poorly inhibited by roscovitine (IC50 > 100 microM).", "output": {"entities": {"gene": [{"text": "cdc2", "start": 61, "end": 65}, {"text": "cyclin B", "start": 66, "end": 74}, {"text": "cdk2", "start": 76, "end": 80}, {"text": "cyclin A", "start": 81, "end": 89}, {"text": "cdk2", "start": 91, "end": 95}, {"text": "cyclin E", "start": 96, "end": 104}, {"text": "cdk5", "start": 109, "end": 113}, {"text": "p35", "start": 114, "end": 117}, {"text": "cdk4", "start": 217, "end": 221}, {"text": "cyclin D1", "start": 222, "end": 231}, {"text": "cdk6", "start": 236, "end": 240}, {"text": "cyclin D2", "start": 241, "end": 250}]}}, "schema": []}
{"input": "Interaction of Ets-1 and the POU-homeodomain protein GHF-1/Pit-1 reconstitutes pituitary-specific gene expression.", "output": {"entities": {"gene": [{"text": "Ets-1", "start": 15, "end": 20}, {"text": "POU-homeodomain protein GHF-1", "start": 29, "end": 58}, {"text": "Pit-1", "start": 59, "end": 64}]}}, "schema": []}
{"input": "Although Pho85 is not essential for viability, Pcl1, 2-Pho85 kinase complexes become essential for Start in the absence of Cln1, 2-Cdc28 kinases.", "output": {"entities": {"gene": [{"text": "Pho85", "start": 9, "end": 14}, {"text": "Pcl1, 2", "start": 47, "end": 54}, {"text": "Pho85", "start": 55, "end": 60}, {"text": "Cln1, 2", "start": 123, "end": 130}, {"text": "Cdc28", "start": 131, "end": 136}]}}, "schema": []}
{"input": "Using the yeast two-hybrid system to screen for proteins which interact with Tax1, we isolated the B subunit of the CCAAT binding protein NF-Y from a HeLa cDNA library.", "output": {"entities": {"gene": [{"text": "Tax1", "start": 77, "end": 81}, {"text": "NF-Y", "start": 138, "end": 142}]}}, "schema": []}
{"input": "Enhancer activity requires both the AP-1 site and these adjacent sequences.", "output": {"entities": {"gene": [{"text": "AP-1 site", "start": 36, "end": 45}]}}, "schema": []}
{"input": "Studies using HLA-DR-B7-1-LFA-3 triple transfectants showed that the LFA-3-induced NF-AT DNA binding activity was negatively regulated by B7-1 costimulation.", "output": {"entities": {"gene": [{"text": "HLA-DR", "start": 14, "end": 20}, {"text": "B7-1", "start": 21, "end": 25}, {"text": "LFA-3", "start": 26, "end": 31}, {"text": "LFA-3", "start": 69, "end": 74}, {"text": "NF-AT", "start": 83, "end": 88}, {"text": "B7-1", "start": 138, "end": 142}]}}, "schema": []}
{"input": "Constitutive activation of Rac1 and RhoA causes tumorigenic transformation of NIH 3T3 cells, and their functions may be required for full Ras transformation.", "output": {"entities": {"gene": [{"text": "Rac1", "start": 27, "end": 31}, {"text": "RhoA", "start": 36, "end": 40}, {"text": "Ras", "start": 138, "end": 141}]}}, "schema": []}
{"input": "Furthermore, Rac1 activation of JNK or SRF, or induction of lamellipodia, was neither necessary nor sufficient for Rac1 transforming activity.", "output": {"entities": {"gene": [{"text": "Rac1", "start": 13, "end": 17}, {"text": "JNK", "start": 32, "end": 35}, {"text": "SRF", "start": 39, "end": 42}, {"text": "Rac1", "start": 115, "end": 119}]}}, "schema": []}
{"input": "Overexpression of the bZip interaction domain of CBP specifically abolishes the positive cross talk between TR and p45/NF-E2.", "output": {"entities": {"gene": [{"text": "CBP", "start": 49, "end": 52}, {"text": "TR", "start": 108, "end": 110}, {"text": "p45", "start": 115, "end": 118}, {"text": "NF-E2", "start": 119, "end": 124}]}}, "schema": []}
{"input": "This inhibitory domain has been deleted in all naturally occurring AHC deletion mutants described to date.", "output": {"entities": {"gene": [{"text": "AHC deletion mutants", "start": 67, "end": 87}]}}, "schema": []}
{"input": "Identification of a promoter-specific transactivation domain in the herpes simplex virus regulatory protein ICP4.", "output": {"entities": {"gene": [{"text": "herpes simplex virus regulatory protein ICP4", "start": 68, "end": 112}]}}, "schema": []}
{"input": "DNA sequencing of a 17-kb segment encompassing a gammaherpesvirus divergent locus (DL-B) between ORF11 and ORF17 revealed the presence of nine viral ORFs with predicted gene products related to cellular proteins.", "output": {"entities": {}}, "schema": []}
{"input": "Studies in mammalian cells have correlated induction of inhibitory tyrosine 15 (Y15) phosphorylation on p34cdc2 with the response to DNA damage.", "output": {"entities": {"gene": [{"text": "p34cdc2", "start": 104, "end": 111}]}}, "schema": []}
{"input": "We report herein the case of a 30-year-old man in whom ectopic mediastinal parathyroid adenoma was detected by 99mTc-methoxyisobutylisonitrile scintigraphy (99mTc-MIBI).", "output": {"entities": {}}, "schema": []}
{"input": "Cardiac endothelin release and infarct size, myocardial blood flow, and ventricular function in canine infarction and reperfusion.", "output": {"entities": {"gene": [{"text": "Cardiac endothelin", "start": 0, "end": 18}]}}, "schema": []}
{"input": "The workup included skin tests (up to 1 microgram/ml, Pharmacia), measurement of specific serum IgE with RAST-CAP (Pharmacia), and CAST with three concentrations of bee (Apis mellifera) and wasp (Vespula spec.) venom (Aquagen ALK).", "output": {"entities": {"gene": [{"text": "IgE", "start": 96, "end": 99}]}}, "schema": []}
{"input": "The proliferation potential protein-related (P2P-R) gene with domains encoding heterogeneous nuclear ribonucleoprotein association and Rb1 binding shows repressed expression during terminal differentiation.", "output": {"entities": {"gene": [{"text": "proliferation potential protein-related", "start": 4, "end": 43}, {"text": "P2P-R", "start": 45, "end": 50}, {"text": "Rb1", "start": 135, "end": 138}]}}, "schema": []}
{"input": "Recent application of recombinant canarypox ALVAC/HIV-1 vectors as vaccine immunogens in HIV-1,-noninfected volunteers has produced CTL responses in a significant number of vaccinees.", "output": {"entities": {}}, "schema": []}
{"input": "The relevance of these elements in conferring anaerobic induction of gpc4 gene expression is discussed.", "output": {"entities": {"gene": [{"text": "gpc4 gene", "start": 69, "end": 78}]}}, "schema": []}
{"input": "Exons A1a and A1b are separated from each other by a 124-nucleotide intron.", "output": {"entities": {}}, "schema": []}
{"input": "A MEK-specific inhibitor (PD098059) (Dudley, D.", "output": {"entities": {"gene": [{"text": "MEK", "start": 2, "end": 5}]}}, "schema": []}
{"input": "These data support the idea that the repression activity of NRSF/REST depends upon the species of promoter to which it is linked and upon the proteins that bind to those promoters.", "output": {"entities": {"gene": [{"text": "NRSF", "start": 60, "end": 64}, {"text": "REST", "start": 65, "end": 69}]}}, "schema": []}
{"input": "Enhanced period-peak analysis of electro-encephalograms using a fast sinc function.", "output": {"entities": {}}, "schema": []}
{"input": "In summary, p56 (lck) activity stimulates G1/S transition in immature thymoblasts and maintains cell viability via transduction of constitutive activation signals downstream to components of the Ras/Raf/MAPK pathway.", "output": {"entities": {"gene": [{"text": "p56", "start": 12, "end": 15}, {"text": "lck", "start": 17, "end": 20}, {"text": "Ras", "start": 195, "end": 198}, {"text": "Raf", "start": 199, "end": 202}, {"text": "MAPK", "start": 203, "end": 207}]}}, "schema": []}
{"input": "These findings suggest that intraarterial neoadjuvant chemotherapy should be effective on advanced cervical cancer.", "output": {"entities": {}}, "schema": []}
{"input": "The FBF questionnaire did not highlight a characteristic basic symptoms profile of schizoaffective disorder, when compared with bipolar affective disorder and schizophrenia.", "output": {"entities": {}}, "schema": []}
{"input": "The alternative sigma factor sigmaB in Staphylococcus aureus: regulation of the sigB operon in response to growth phase and heat shock", "output": {"entities": {"gene": [{"text": "sigma factor sigmaB in Staphylococcus aureus", "start": 16, "end": 60}, {"text": "sigB operon", "start": 80, "end": 91}]}}, "schema": []}
{"input": "Cognate promoter elements implicated in glucocorticoid-and cAMP-mediated regulation as well as in liver-, myeloid-, and lymphocyte-specific expression are located within the 5' flanking sequence.", "output": {"entities": {}}, "schema": []}
{"input": "We have studied the biokinetics of BLM labeled with indium-111 (In-111).", "output": {"entities": {}}, "schema": []}
{"input": "CD3 cross-linking induced tyrosine phosphorylation of Sam68 in uninfected T cells.", "output": {"entities": {"gene": [{"text": "CD3", "start": 0, "end": 3}, {"text": "Sam68", "start": 54, "end": 59}]}}, "schema": []}
{"input": "Acetoin-dependent expression of the acoABCD operon could be restored in the E. coli acoK mutants by supplying a plasmid carrying an intact acoK, suggesting a transactivating function of the gene product.", "output": {"entities": {"gene": [{"text": "acoABCD operon", "start": 36, "end": 50}, {"text": "E. coli acoK mutants", "start": 76, "end": 96}, {"text": "acoK", "start": 139, "end": 143}]}}, "schema": []}
{"input": "Mutations in the alpha and sigma-70 subunits of RNA polymerase affect expression of the mer operon.", "output": {"entities": {"gene": [{"text": "alpha and sigma-70 subunits of RNA polymerase", "start": 17, "end": 62}, {"text": "mer operon", "start": 88, "end": 98}]}}, "schema": []}
{"input": "Taken together, we provide evidence for the existence of an activator, NFE, which in combination with the p50 and c-Rel proteins, are part of the transcription factor machinery that regulates 3' enhancer activity, and thus the control of the IgH locus in late B lymphocyte development.", "output": {"entities": {"gene": [{"text": "NFE", "start": 71, "end": 74}, {"text": "p50", "start": 106, "end": 109}, {"text": "c-Rel proteins", "start": 114, "end": 128}, {"text": "IgH locus", "start": 242, "end": 251}]}}, "schema": []}
{"input": "The neuroprotective efficacy of the selective N-type voltage-sensitive calcium channel blocker, SNX-111, was evaluated in spontaneously hypertensive rats subjected to 60 min of focal cerebral ischemia by permanent ligation of the right common carotid artery and temporary occlusion of the right middle cerebral artery.", "output": {"entities": {}}, "schema": []}
{"input": "The genes encoding the transcription factor yTAFII60, the G4p1 protein and a putative glucose transporter are contained in a 12. 3 kb DNA fragment on the left arm of Saccharomyces cerevisiae chromosome VII.", "output": {"entities": {"gene": [{"text": "transcription factor yTAFII60", "start": 23, "end": 52}, {"text": "G4p1 protein", "start": 58, "end": 70}]}}, "schema": []}
{"input": "The protector doubled the estimated fall distance for fracture of the trochanter.", "output": {"entities": {}}, "schema": []}
{"input": "Marinol/marijuana usage was associated with depressed CD4 + counts and elevated amylase levels within the DDI subgroup.", "output": {"entities": {"gene": [{"text": "CD4 +", "start": 54, "end": 59}, {"text": "amylase", "start": 80, "end": 87}]}}, "schema": []}
{"input": "METHODS: Fifty-eight patients who underwent a curative hepatic resection for HCC and whose preoperative AFP levels were > 100 ng/ml, were selected for this study.", "output": {"entities": {"gene": [{"text": "AFP", "start": 104, "end": 107}]}}, "schema": []}
{"input": "Calmodulin-binding peptide (CBP), a peptide of 26 amino acids derived from muscle myosin light chain kinase (MLCK), binds to calmodulin with nanomolar affinity.", "output": {"entities": {"gene": [{"text": "Calmodulin-binding peptide", "start": 0, "end": 26}, {"text": "CBP", "start": 28, "end": 31}, {"text": "muscle myosin light chain kinase", "start": 75, "end": 107}, {"text": "MLCK", "start": 109, "end": 113}, {"text": "calmodulin", "start": 125, "end": 135}]}}, "schema": []}
{"input": "Here we show that the type of tyrosine kinase receptor stimulated also participates in the nature of the cAMP effect.", "output": {"entities": {"gene": [{"text": "tyrosine kinase receptor", "start": 30, "end": 54}]}}, "schema": []}
{"input": "To gain insight into the possible involvement of p21 in liver cell growth, the expression and regulation of the p21 gene was evaluated in rodent models of liver regeneration and specimens of human liver diseases.", "output": {"entities": {"gene": [{"text": "p21", "start": 49, "end": 52}, {"text": "p21 gene", "start": 112, "end": 120}]}}, "schema": []}
{"input": "Northern blot analysis of LeMT (A) and LeMT (B) showed that transcripts of both MT-like genes were more abundant in leaves than roots in tomato plants grown without addition of extra metal ions, a characteristic of type II MTs.", "output": {"entities": {"gene": [{"text": "LeMT (A)", "start": 26, "end": 34}, {"text": "LeMT (B)", "start": 39, "end": 47}, {"text": "MT-like genes", "start": 80, "end": 93}, {"text": "type II MTs", "start": 215, "end": 226}]}}, "schema": []}
{"input": "The HBP gene is composed of eight exons covering 19. 5 kb on the short arm of chromosome 4.", "output": {"entities": {"gene": [{"text": "HBP gene", "start": 4, "end": 12}]}}, "schema": []}
{"input": "In some instances, this is partly mediated by the expression of virally encoded proteases which lead to the cleavage of initiation factor eIF4G.", "output": {"entities": {"gene": [{"text": "initiation factor eIF4G", "start": 120, "end": 143}]}}, "schema": []}
{"input": "The best endometrial ablation was seen when SnET2 was given by intrauterine administration with light treatment at 150 J/cm 24 hours later.", "output": {"entities": {}}, "schema": []}
{"input": "Unlike class II-and III-specific TBP-TAF complexes, the corresponding murine and human class I-specific transcription initiation factor TIF-IB/SL1 exhibits a pronounced selectivity for its homologous promoter.", "output": {"entities": {"gene": [{"text": "TBP", "start": 33, "end": 36}, {"text": "TAF", "start": 37, "end": 40}, {"text": "TIF-IB", "start": 136, "end": 142}, {"text": "SL1", "start": 143, "end": 146}]}}, "schema": []}
{"input": "We now describe the identification of DEK as this 43-kDa pets factor.", "output": {"entities": {"gene": [{"text": "DEK", "start": 38, "end": 41}, {"text": "43-kDa pets factor", "start": 50, "end": 68}]}}, "schema": []}
{"input": "These elements comprise a binding site for Krox proteins, one for nuclear factor 1, an octamer motif that binds POU-homeodomain proteins, and a novel TN control element.", "output": {"entities": {"gene": [{"text": "Krox proteins", "start": 43, "end": 56}, {"text": "nuclear factor 1", "start": 66, "end": 82}, {"text": "POU-homeodomain proteins", "start": 112, "end": 136}, {"text": "TN control element", "start": 150, "end": 168}]}}, "schema": []}
{"input": "Tissue samples were obtained either from rats that had been exposed to opiate withdrawal following a seven day morphine infusion or sham treated control subjects.", "output": {"entities": {}}, "schema": []}
{"input": "Therefore, the impaired floor plate development in oep mutants is not caused by the absence of the floor plate inducer shh.", "output": {"entities": {"gene": [{"text": "oep mutants", "start": 51, "end": 62}, {"text": "floor plate inducer shh", "start": 99, "end": 122}]}}, "schema": []}
{"input": "RESULTS: The medians of average daily CD34 + cell yields for patients who received paclitaxel plus CY, CE, and CEP with G-CSF were 12. 9, 11. 03, and 5. 37 x 10 (6)/kg, respectively, compared with 2. 02 x 10 (6)/kg in the reference group that received CY with G-CSF (P = <. 0001,. 002, and. 09, respectively).", "output": {"entities": {"gene": [{"text": "CD34 +", "start": 38, "end": 44}, {"text": "G-CSF", "start": 120, "end": 125}, {"text": "G-CSF", "start": 260, "end": 265}]}}, "schema": []}
{"input": "Increased p53 activity induced by OP is not due to elevated p53 mRNA nor to protein levels.", "output": {"entities": {"gene": [{"text": "p53", "start": 10, "end": 13}, {"text": "p53 mRNA", "start": 60, "end": 68}]}}, "schema": []}
{"input": "CONCLUSION: Chronic administration of misoprostol may have caused a negative natriuretic effect in cirrhotic patients with ascites.", "output": {"entities": {}}, "schema": []}
{"input": "The intensity of the SSTEs is an order of magnitude larger than that of the MSEs and determines the signal contrast if both effects are selected simultaneously.", "output": {"entities": {}}, "schema": []}
{"input": "In eukaryotic cells, premature termination of translation at nonsense codons has been implicated as the cause of a variety of posttranscriptional events, including rapid mRNA decay in the cytoplasm or the nucleus, altered splice site selection, and exon skipping.", "output": {"entities": {}}, "schema": []}
{"input": "The region of plasmid pCM2 encoding the pathogenicity locus pat-1 was mapped by deletion analysis and complementation studies to a 1. 5-kb Bg/II/SmaI DNA fragment.", "output": {"entities": {"gene": [{"text": "pathogenicity locus pat-1", "start": 40, "end": 65}, {"text": "Bg/II", "start": 139, "end": 144}, {"text": "SmaI", "start": 145, "end": 149}]}}, "schema": []}
{"input": "Transient cotransfection of tat cDNA in sense orientation (tat/S), together with a plasmid containing the c-fos promoter (FC3, from-711 to + 42) in front of the bacterial chloramphenicol acetyltransferase (CAT) gene significantly enhanced CAT activity in Jurkat cells activated by the addition of 15% fetal calf serum (FCS) or 5 micrograms/mL phytohemagglutinin plus 10 (-7) mol/L phorbol myristate acetate (PMA) and U937 cells activated by 15% FCS or 10 (-7) mol/L PMA.", "output": {"entities": {"gene": [{"text": "tat cDNA", "start": 28, "end": 36}, {"text": "tat/S", "start": 59, "end": 64}, {"text": "c-fos promoter", "start": 106, "end": 120}, {"text": "FC3", "start": 122, "end": 125}, {"text": "bacterial chloramphenicol acetyltransferase", "start": 161, "end": 204}, {"text": "CAT", "start": 206, "end": 209}, {"text": "CAT", "start": 239, "end": 242}, {"text": "phytohemagglutinin", "start": 343, "end": 361}]}}, "schema": []}
{"input": "Snail mortality did not differ among the various treatment conditions.", "output": {"entities": {}}, "schema": []}
{"input": "Exploratory-motor task to evaluate right frontal lobe damage.", "output": {"entities": {}}, "schema": []}
{"input": "To avoid complications, accurate quantitative analysis of NO and NO2 is necessary during this therapy.", "output": {"entities": {}}, "schema": []}
{"input": "Our results demonstrate that cis elements positioned between the alpha 3 and beta 4 coding regions are important for establishing part of the restricted CNS patterns of beta 4, alpha 3, and alpha 5 gene transcription.", "output": {"entities": {"gene": [{"text": "alpha 3", "start": 65, "end": 72}, {"text": "beta 4", "start": 77, "end": 83}, {"text": "beta 4", "start": 169, "end": 175}, {"text": "alpha 3", "start": 177, "end": 184}, {"text": "alpha 5 gene", "start": 190, "end": 202}]}}, "schema": []}
{"input": "RNase protection experiments confirmed the presence of the GHR1-279 variant in IM-9 cells and human liver.", "output": {"entities": {"gene": [{"text": "RNase", "start": 0, "end": 5}, {"text": "GHR1-279 variant", "start": 59, "end": 75}]}}, "schema": []}
{"input": "Functional tests using a reporter gene, containing Stat5-binding elements, confirmed that while the variant form was inactive by itself, it could inhibit the function of the full-length receptor.", "output": {"entities": {"gene": [{"text": "Stat5-binding elements", "start": 51, "end": 73}]}}, "schema": []}
{"input": "Conversely, activated glucocorticoid receptors suppressed the transactivation function of p53, while transrepression by p53 was largely unaffected.", "output": {"entities": {"gene": [{"text": "glucocorticoid receptors", "start": 22, "end": 46}, {"text": "p53", "start": 90, "end": 93}, {"text": "p53", "start": 120, "end": 123}]}}, "schema": []}
{"input": "This promoter segment could drive expression of a luciferase reporter gene, could confer correct transcriptional initiation to the reporter and could confer the EGF-responsiveness previously observed in the native gene.", "output": {"entities": {"gene": [{"text": "luciferase reporter gene", "start": 50, "end": 74}, {"text": "EGF", "start": 161, "end": 164}]}}, "schema": []}
{"input": "This is the first report that an in vitro-synthesized alphavirus RNA lacking a poly (A) tail can initiate infection and produce 3' polyadenylated viral genome in vivo.", "output": {"entities": {}}, "schema": []}
{"input": "The human coreceptor was as active as the simian for SIV entry.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: Among women, the age-related decline in BMD at all non-spine skeletal sites was significantly different from zero, with the largest decline seen at the femoral neck (-. 0038 g/cm2/y, p <. 001) and the smallest at the trochanter of the hip (-. 0023 g/cm2/y, p =. 03).", "output": {"entities": {}}, "schema": []}
{"input": "Sixty-nine (44%) patients were administered 250 MBq (7 mCi) 99Tcm-tetrofosmin at rest followed 4 h later by 750 MBq (21 mCi) during stress (the 1 day protocol), whereas 88 (56%) patients had rest and stress imaging studies on two separate days, receiving a 500 MBq (14 mCi) dose of 99Tcm-tetrofosmin on each occasion (the 2 day protocol).", "output": {"entities": {}}, "schema": []}
{"input": "Myocardial SPET imaging with 99Tcm-tetrofosmin in clinical practice: comparison of a 1 day and a 2 day imaging protocol.", "output": {"entities": {}}, "schema": []}
{"input": "99Tcm-DMP-HSA showed an almost identical behaviour to in vitro labelled red blood cells (RBCs), which are generally considered the reference standard for blood pool agents.", "output": {"entities": {}}, "schema": []}
{"input": "Relief from autoinhibition and a subsequent 10-60-fold increase in V (max) have been observed upon N-SH2 domain engagement by a specific phosphotyrosyl ligand or upon deletion of the SH2 domains to yield the catalytic PTPase domain.", "output": {"entities": {"gene": [{"text": "N-SH2 domain", "start": 99, "end": 111}, {"text": "SH2 domains", "start": 183, "end": 194}, {"text": "PTPase domain", "start": 218, "end": 231}]}}, "schema": []}
{"input": "We have thus identified the first mammalian homolog of yeast UPF1, a protein that regulates levels of nonsense mRNA, and we tentatively name this protein human HUPF1 (for human homolog of UPF1).", "output": {"entities": {"gene": [{"text": "mammalian homolog of yeast UPF1", "start": 34, "end": 65}, {"text": "human HUPF1", "start": 154, "end": 165}, {"text": "human homolog of UPF1", "start": 171, "end": 192}]}}, "schema": []}
{"input": "A miracle cure and its solution", "output": {"entities": {}}, "schema": []}
{"input": "The addition of zidovudine did not influence this transfer.", "output": {"entities": {}}, "schema": []}
{"input": "DNA strand exchange catalyzed by Rad51 protein is also greatly stimulated by RPA.", "output": {"entities": {"gene": [{"text": "Rad51 protein", "start": 33, "end": 46}, {"text": "RPA", "start": 77, "end": 80}]}}, "schema": []}
{"input": "Ume6p, which also controls the expression of early meiotic genes, represses CAR1 expression through a sequence called URS, as a function of nitrogen availability.", "output": {"entities": {"gene": [{"text": "Ume6p", "start": 0, "end": 5}, {"text": "CAR1", "start": 76, "end": 80}]}}, "schema": []}
{"input": "The second class of cDNA hybridized to a 13 kb transcript, which was approximately twice as large as the mammalian lactase mRNA.", "output": {"entities": {"gene": [{"text": "mammalian lactase mRNA", "start": 105, "end": 127}]}}, "schema": []}
{"input": "In cell lines transformed by BCR/ABL, CRKL was tyrosine phosphorylated, while CRK was not.", "output": {"entities": {"gene": [{"text": "BCR", "start": 29, "end": 32}, {"text": "ABL", "start": 33, "end": 36}, {"text": "CRKL", "start": 38, "end": 42}, {"text": "CRK", "start": 78, "end": 81}]}}, "schema": []}
{"input": "In untransformed cells, three major proteins coprecipitated with CRKL, identified as C3G, SOS and c-ABL.", "output": {"entities": {"gene": [{"text": "CRKL", "start": 65, "end": 69}, {"text": "C3G", "start": 85, "end": 88}, {"text": "SOS", "start": 90, "end": 93}, {"text": "c-ABL", "start": 98, "end": 103}]}}, "schema": []}
{"input": "RESULTS: Nodular opacities, mainly centrilobular in distribution, were the most common finding, seen in 21 (72%) and 15 (65%) of patients with MTB and NTMB, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Circulating oxytocin in male guinea pigs affected by the female cohabitation and reproductive condition.", "output": {"entities": {"gene": [{"text": "oxytocin", "start": 12, "end": 20}]}}, "schema": []}
{"input": "Antisense transcription of a murine FGFR-3 psuedogene during fetal developement.", "output": {"entities": {"gene": [{"text": "murine FGFR-3 psuedogene", "start": 29, "end": 53}]}}, "schema": []}
{"input": "A previous report described that a 548-bp BglII-SmaI fragment has an SSO activity (ori2; Kataoka et al., Mol.", "output": {"entities": {"gene": [{"text": "BglII", "start": 42, "end": 47}, {"text": "SmaI", "start": 48, "end": 52}]}}, "schema": []}
{"input": "The human CD38 gene consists of 8 exons that extend more than 77 kb on the human genome.", "output": {"entities": {"gene": [{"text": "human CD38 gene", "start": 4, "end": 19}]}}, "schema": []}
{"input": "Type IV splice pattern, containing exon U3 and S was found both in kidney and ovary.", "output": {"entities": {}}, "schema": []}
{"input": "GH deficiency may be absolute, but often is not and the diagnosis may be complicated by a constellation of physical and hormonal findings that are along a spectrum from low normal GH sufficiency to absent GH secretion.", "output": {"entities": {"gene": [{"text": "GH", "start": 0, "end": 2}, {"text": "GH", "start": 180, "end": 182}, {"text": "GH", "start": 205, "end": 207}]}}, "schema": []}
{"input": "Positive CRP test were seen.", "output": {"entities": {"gene": [{"text": "CRP", "start": 9, "end": 12}]}}, "schema": []}
{"input": "During the febrile period, pleocytosis was associated with high levels of IgG, IL-6, TNF-alpha, and PGE2 in the cerebrospinal fluid.", "output": {"entities": {"gene": [{"text": "IgG", "start": 74, "end": 77}, {"text": "IL-6", "start": 79, "end": 83}, {"text": "TNF-alpha", "start": 85, "end": 94}]}}, "schema": []}
{"input": "Recognition mechanisms of the minus-strand origin of phage f1 by Escherichia coli RNA polymerase.", "output": {"entities": {"gene": [{"text": "Escherichia coli RNA polymerase", "start": 65, "end": 96}]}}, "schema": []}
{"input": "The minimum and essential subunits for RNA synthesis have not yet been identified.", "output": {"entities": {}}, "schema": []}
{"input": "Syndecan-4 is a focal adhesion component, and this interaction may both localize PKC and amplify its activity at sites of forming adhesions.", "output": {"entities": {"gene": [{"text": "Syndecan-4", "start": 0, "end": 10}, {"text": "PKC", "start": 81, "end": 84}]}}, "schema": []}
{"input": "The 3ASubE cells expressing CXCR2 with mutation of Ser-346,-347, and-348 to alanine, or with mutation of only one serine in this domain, continue to be phosphorylated in response to ligand and are 60-70% desensitized following the initial ligand challenge.", "output": {"entities": {"gene": [{"text": "CXCR2", "start": 28, "end": 33}]}}, "schema": []}
{"input": "Members of the MAPK family include the extracellular response kinases (ERKs or p42/44 (MAPK)), the c-Jun amino-terminal kinases (JNKs), and the p38/Hog 1 protein kinases.", "output": {"entities": {"gene": [{"text": "MAPK family", "start": 15, "end": 26}, {"text": "extracellular response kinases", "start": 39, "end": 69}, {"text": "ERKs", "start": 71, "end": 75}, {"text": "p42/44", "start": 79, "end": 85}, {"text": "MAPK", "start": 87, "end": 91}, {"text": "c-Jun amino-terminal kinases", "start": 99, "end": 127}, {"text": "JNKs", "start": 129, "end": 133}, {"text": "p38", "start": 144, "end": 147}, {"text": "Hog 1", "start": 148, "end": 153}]}}, "schema": []}
{"input": "MOP5 contained the characteristic PAS domain and a variable C terminus; it is possible that the cDNA contains a bHLH domain, but the entire open reading frame has yet to be completed.", "output": {"entities": {"gene": [{"text": "MOP5", "start": 0, "end": 4}, {"text": "PAS", "start": 34, "end": 37}]}}, "schema": []}
{"input": "Some 8. 8 kb of the Lactobacillus sake plasmid pCIM1 was sequenced, revealing eight tightly clustered open reading frames (ORFs) downstream from lasA, which encodes pre-lactocin S.", "output": {"entities": {"gene": [{"text": "lasA", "start": 145, "end": 149}, {"text": "pre-lactocin S", "start": 165, "end": 179}]}}, "schema": []}
{"input": "Purified Pra was also shown to physically interact with pyruvate kinase (Pk); Pk and Pra can form a complex, but when the 12-kDa Ndk, Pk, and Pra are all present, Pk has a higher affinity than Pra for forming a complex with the 12-kDa Ndk.", "output": {"entities": {"gene": [{"text": "Purified Pra", "start": 0, "end": 12}, {"text": "pyruvate kinase", "start": 56, "end": 71}, {"text": "Pk", "start": 73, "end": 75}, {"text": "Pk", "start": 78, "end": 80}, {"text": "Pra", "start": 85, "end": 88}, {"text": "12-kDa Ndk", "start": 122, "end": 132}, {"text": "Pk", "start": 134, "end": 136}, {"text": "Pra", "start": 142, "end": 145}, {"text": "Pk", "start": 163, "end": 165}, {"text": "Pra", "start": 193, "end": 196}, {"text": "12-kDa Ndk", "start": 228, "end": 238}]}}, "schema": []}
{"input": "Molecular characterization of a large Borrelia burgdorferi motility operon which is initiated by a consensus sigma70 promoter.", "output": {"entities": {"gene": [{"text": "sigma70 promoter", "start": 109, "end": 125}]}}, "schema": []}
{"input": "M. leprae OxyR was overproduced and purified, and its binding to the oxyR-ahpC intergenic region of M. leprae was demonstrated.", "output": {"entities": {"gene": [{"text": "M. leprae OxyR", "start": 0, "end": 14}, {"text": "oxyR", "start": 69, "end": 73}, {"text": "ahpC", "start": 74, "end": 78}]}}, "schema": []}
{"input": "The binding site for OxyR overlapped P1oxyR, reminiscent of the autoregulatory loops controlling expression of oxyR in enteric bacteria and characteristic of the LysR superfamily in general.", "output": {"entities": {"gene": [{"text": "OxyR", "start": 21, "end": 25}, {"text": "P1oxyR", "start": 37, "end": 43}, {"text": "oxyR", "start": 111, "end": 115}, {"text": "LysR superfamily", "start": 162, "end": 178}]}}, "schema": []}
{"input": "Thirty-five patients were included.", "output": {"entities": {}}, "schema": []}
{"input": "Grade 3-4 mucositis was present in 13% of the cycles.", "output": {"entities": {}}, "schema": []}
{"input": "Therefore more active and tolerable salvage regimens are needed.", "output": {"entities": {}}, "schema": []}
{"input": "None of these organic manifestations was discovered by scintigraphic means.", "output": {"entities": {}}, "schema": []}
{"input": "While TGF-beta1 does not alter the mitogen-induced expression and abundance of G1 phase cyclin D1 and cdks 4 and 2 in MCs, it inhibits cyclin E-cdk 2 activity, thus preventing mitogen-elicited phosphorylation and inactivation of pRb in G1 phase and transition to S phase.", "output": {"entities": {"gene": [{"text": "TGF-beta1", "start": 6, "end": 15}, {"text": "cyclin D1", "start": 88, "end": 97}, {"text": "cdks 4 and 2", "start": 102, "end": 114}, {"text": "cyclin E", "start": 135, "end": 143}, {"text": "cdk 2", "start": 144, "end": 149}, {"text": "pRb", "start": 229, "end": 232}]}}, "schema": []}
{"input": "However, the range of values observed is suggestive of the need to investigate districts with contrasting values of SYPLR with respect to the inter-relationships between sociodemographic characteristics, duration of symptoms, clinical presentation and treatment efficacy.", "output": {"entities": {}}, "schema": []}
{"input": "The prominent lesions were confined to the cerebral surface layer and leptomeningeal tissue including the arachnoid vessels, which were all bathed in the cerebrospinal fluid, suggesting that some necrotizing toxins had been secreted into the fluid by the B. cereus.", "output": {"entities": {}}, "schema": []}
{"input": "This fragment contained the C-terminal 47 nucleotides of leuB, encoding 3-isopropylmalate dehydrogenase; asd, encoding aspartate-beta-semialdehyde dehydrogenase (Asd); and orfA, whose product showed similarity to the Asd proteins from Vibrio spp.", "output": {"entities": {"gene": [{"text": "leuB", "start": 57, "end": 61}, {"text": "3-isopropylmalate dehydrogenase", "start": 72, "end": 103}, {"text": "asd", "start": 105, "end": 108}, {"text": "aspartate-beta-semialdehyde dehydrogenase", "start": 119, "end": 160}, {"text": "Asd", "start": 162, "end": 165}, {"text": "Asd proteins from Vibrio spp", "start": 217, "end": 245}]}}, "schema": []}
{"input": "Hovenitin I and (+)-ampelopsin, both of which were principal ingredients of the active fractions from this natural medicine, were found to show an inhibitory activity on the ethanol-induced muscle relaxation in rats.", "output": {"entities": {}}, "schema": []}
{"input": "Purified P7 could be assembled onto particles lacking P7 and particles lacking both P2 (RNA polymerase) and P7.", "output": {"entities": {"gene": [{"text": "Purified P7", "start": 0, "end": 11}, {"text": "P7", "start": 54, "end": 56}, {"text": "P2", "start": 84, "end": 86}, {"text": "RNA polymerase", "start": 88, "end": 102}, {"text": "P7", "start": 108, "end": 110}]}}, "schema": []}
{"input": "However, the same U1A peptide, when conjugated to BSA, inhibits vertebrate PAP.", "output": {"entities": {"gene": [{"text": "U1A peptide", "start": 18, "end": 29}, {"text": "BSA", "start": 50, "end": 53}, {"text": "vertebrate PAP", "start": 64, "end": 78}]}}, "schema": []}
{"input": "Plasma levels of protein C, protein S, and antithrombin III in patients with subarachnoid haemorrhage.", "output": {"entities": {"gene": [{"text": "protein C", "start": 17, "end": 26}, {"text": "protein S", "start": 28, "end": 37}, {"text": "antithrombin III", "start": 43, "end": 59}]}}, "schema": []}
{"input": "Idiopathic bilateral recurrent branch retinal arterial occlusion (IBRBRAO) is a rare syndrome characterized by migraine headaches, tinnitus, vertigo, hearing loss, and recurrent branch retinal artery occlusion of unknown etiology.", "output": {"entities": {}}, "schema": []}
{"input": "Epithelial and corneal thickness measurements by in vivo confocal microscopy through focusing (CMTF).", "output": {"entities": {}}, "schema": []}
{"input": "Sequences downstream of the two human CA genes, possibly containing homologous enhancer elements, have not yet been reported.", "output": {"entities": {"gene": [{"text": "human CA genes", "start": 32, "end": 46}]}}, "schema": []}
{"input": "Recombinant plasmids containing the entire 322 nt 5' UTR of exon 1 and a 1630 nt segment of 5' flanking sequence stimulated luciferase activity nearly 70 times higher than a promoterless control plasmid.", "output": {"entities": {"gene": [{"text": "luciferase", "start": 124, "end": 134}]}}, "schema": []}
{"input": "Analysis for DNA-protein interactions by in vitro DNase-I footprinting identified a broad region of protection extending from nt-12 to + 38.", "output": {"entities": {"gene": [{"text": "DNase-I", "start": 50, "end": 57}]}}, "schema": []}
{"input": "It is also homologous to other sugar carriers from human, mouse and Escherichia coli.", "output": {"entities": {}}, "schema": []}
{"input": "Until now, each of these loci was considered to contain three genes (for regulator, permease and alpha-glucosidase), but a fourth gene, presumably an extra alpha-glucosidase gene, was found at MAL1 adjacent to the usual cluster of three genes.", "output": {"entities": {"gene": [{"text": "regulator", "start": 73, "end": 82}, {"text": "permease", "start": 84, "end": 92}, {"text": "alpha-glucosidase", "start": 97, "end": 114}, {"text": "alpha-glucosidase gene", "start": 156, "end": 178}, {"text": "MAL1", "start": 193, "end": 197}]}}, "schema": []}
{"input": "Autorosette-forming cells are characterized by a high activity of alkaline and acid phosphatases and low NBT-test values.", "output": {"entities": {"gene": [{"text": "alkaline and acid phosphatases", "start": 66, "end": 96}]}}, "schema": []}
{"input": "Analysis of homologous DNA sequences within the first intron of the mouse and human mts1 genes: kB-like site and microsatellite DNA", "output": {"entities": {"gene": [{"text": "mouse and human mts1 genes", "start": 68, "end": 94}, {"text": "kB-like site", "start": 96, "end": 108}]}}, "schema": []}
{"input": "The integration at the VIP CyRE of the Jak-Stat and AP-1 signaling pathways with other pre-existing proteins provides a cellular mechanism for cell-and cytokine-specific signaling.", "output": {"entities": {"gene": [{"text": "VIP CyRE", "start": 23, "end": 31}, {"text": "Jak", "start": 39, "end": 42}, {"text": "Stat", "start": 43, "end": 47}, {"text": "AP-1", "start": 52, "end": 56}]}}, "schema": []}
{"input": "These studies point to the involvement of the MAP kinase pathway in the activation of monocytic cells during transmigration to inflammatory sites.", "output": {"entities": {"gene": [{"text": "MAP kinase", "start": 46, "end": 56}]}}, "schema": []}
{"input": "Our results show that the temperature-sensitive rad54-3 allele blocks mitotic recombination between tandemly repeated DYZ3 satellite sequences and significantly stabilizes a human DYZ5 satellite-containing YAC clone.", "output": {"entities": {"gene": [{"text": "temperature-sensitive rad54-3 allele", "start": 26, "end": 62}, {"text": "DYZ3 satellite sequences", "start": 118, "end": 142}, {"text": "human DYZ5", "start": 174, "end": 184}]}}, "schema": []}
{"input": "A P22 R17 derivative with an OcRNA site (P22 R17 [A (-10) U]) develops lytically following infection of these strains.", "output": {"entities": {}}, "schema": []}
{"input": "Circularized Ac/Ds transposons: formation, structure and fate.", "output": {"entities": {"gene": [{"text": "Ac", "start": 13, "end": 15}, {"text": "Ds", "start": 16, "end": 18}]}}, "schema": []}
{"input": "In this study, we have examined the regulation of B-Myb activity by cyclin-Cdks.", "output": {"entities": {"gene": [{"text": "B-Myb", "start": 50, "end": 55}, {"text": "cyclin", "start": 68, "end": 74}, {"text": "Cdks", "start": 75, "end": 79}]}}, "schema": []}
{"input": "Candidate tumor suppressor genes, Mts1 (p16INK4a) and Mts2 (p15INK4b), have been mapped to this region, but by Southern blot analysis, no homozygous deletions were detected in either gene.", "output": {"entities": {"gene": [{"text": "Mts1", "start": 34, "end": 38}, {"text": "p16INK4a", "start": 40, "end": 48}, {"text": "Mts2", "start": 54, "end": 58}, {"text": "p15INK4b", "start": 60, "end": 68}]}}, "schema": []}
{"input": "Excision repair at the level of the nucleotide in the Saccharomyces cerevisiae MFA2 gene: mapping of where enhanced repair in the transcribed strand begins or ends and identification of only a partial rad16 requisite for repairing upstream control sequences.", "output": {"entities": {"gene": [{"text": "Saccharomyces cerevisiae MFA2 gene", "start": 54, "end": 88}, {"text": "rad16", "start": 201, "end": 206}]}}, "schema": []}
{"input": "This locus maps approximately 160 kbp from the genes encoding cytadherence-associated proteins HMW1 and HMW3, and yet insertions therein result in loss of these proteins and a hemadsorption-negative (HA-) phenotype, prompting the designation cytadherence-regulatory locus (crl).", "output": {"entities": {"gene": [{"text": "HMW1", "start": 95, "end": 99}, {"text": "HMW3", "start": 104, "end": 108}, {"text": "cytadherence-regulatory locus", "start": 242, "end": 271}, {"text": "crl", "start": 273, "end": 276}]}}, "schema": []}
{"input": "Coliphage 186 B is a 72-amino acid protein belonging to the Ogr family of analogous transcription factors present in P2-like phage, which contain a Cys-X2-Cys-X22-Cys-X4-Cys presumptive zinc-finger motif.", "output": {"entities": {"gene": [{"text": "Coliphage 186 B", "start": 0, "end": 15}, {"text": "Ogr", "start": 60, "end": 63}]}}, "schema": []}
{"input": "The UV absorption spectrum revealed a shoulder at 250 nm, characteristic of CysS-Cd (II) ligand-to-metal charge-transfer transitions, and the difference absorption coefficient after acidification (delta epsilon 248, 24 mM-1 cm-1) indicated the presence of a Cd (Cys-S) 4 center.", "output": {"entities": {}}, "schema": []}
{"input": "Diacylglycerol kinase (DGK) attenuates levels of second messenger diacylglycerol in cells and produces another (putative) messenger, phosphatidic acid.", "output": {"entities": {"gene": [{"text": "Diacylglycerol kinase", "start": 0, "end": 21}, {"text": "DGK", "start": 23, "end": 26}]}}, "schema": []}
{"input": "Recently, we have reported the cloning of the germ cell-specific, nuclear orphan receptor germ cell nuclear factor (GCNF)/RTR.", "output": {"entities": {"gene": [{"text": "germ cell nuclear factor", "start": 90, "end": 114}, {"text": "GCNF", "start": 116, "end": 120}, {"text": "RTR", "start": 122, "end": 125}]}}, "schema": []}
{"input": "Based on the sequence of the conRTRE, we located a putative RTRE, referred to as P2-RE, in the 5' promoter-flanking region of the mouse protamine 2 gene, which is induced during the same stage of spermatogenesis as RTR.", "output": {"entities": {"gene": [{"text": "conRTRE", "start": 29, "end": 36}, {"text": "RTRE", "start": 60, "end": 64}, {"text": "P2-RE", "start": 81, "end": 86}, {"text": "mouse protamine 2 gene", "start": 130, "end": 152}, {"text": "RTR", "start": 215, "end": 218}]}}, "schema": []}
{"input": "Active complexes eluted at a higher molecular weight than inactive complexes, were relatively deficient in both p21 and p27, and contained Cdk2 with increased threonine 160 phosphorylation, consistent with a mechanism of activation of cyclin E-Cdk2 involving both reduced CDK inhibitor association and CDK-activating kinase-mediated phosphorylation of Cdk2.", "output": {"entities": {"gene": [{"text": "p21", "start": 112, "end": 115}, {"text": "p27", "start": 120, "end": 123}, {"text": "Cdk2", "start": 139, "end": 143}, {"text": "cyclin E", "start": 235, "end": 243}, {"text": "Cdk2", "start": 244, "end": 248}, {"text": "CDK", "start": 272, "end": 275}, {"text": "CDK-activating kinase", "start": 302, "end": 323}, {"text": "Cdk2", "start": 352, "end": 356}]}}, "schema": []}
{"input": "Thirty Class I and Class II recessions in 30 patients were treated with a modified subepithelial connective tissue graft procedure.", "output": {"entities": {}}, "schema": []}
{"input": "The derivatives of the latter two cell lines showed increased expression of the p27Kip1 protein and inhibition of cell growth.", "output": {"entities": {"gene": [{"text": "p27Kip1 protein", "start": 80, "end": 95}]}}, "schema": []}
{"input": "The perioperative mortality of all patients was 1. 9%, the mortality of patients older than 70 years was 4. 3%.", "output": {"entities": {}}, "schema": []}
{"input": "Chronic renal failure patients essentially die from cardiovascular causes, and the frequency of malignant disease responsible for death is estimated to be 10%.", "output": {"entities": {}}, "schema": []}
{"input": "The new FIGO definition of cervical cancer stage IA: a critique.", "output": {"entities": {}}, "schema": []}
{"input": "The effect of Vpu on class I biogenesis was analyzed in more detail using a Vpu-expressing recombinant vaccinia virus (VV).", "output": {"entities": {"gene": [{"text": "Vpu", "start": 14, "end": 17}, {"text": "Vpu", "start": 76, "end": 79}]}}, "schema": []}
{"input": "Inductively coupled plasma atomic emission spectroscopy was employed to obtain the tissue silicon measurements.", "output": {"entities": {}}, "schema": []}
{"input": "An egg protein, lysozyme, is a still unlabeled additive currently used in cheese preparation.", "output": {"entities": {"gene": [{"text": "lysozyme", "start": 16, "end": 24}]}}, "schema": []}
{"input": "Similarly, the DNA-binding activity of activator protein 1 (AP-1) is modified by a DNA repair enzyme, redox factor 1 (Ref-1), which is identical to a DNA repair enzyme, AP endonuclease.", "output": {"entities": {"gene": [{"text": "activator protein 1", "start": 39, "end": 58}, {"text": "AP-1", "start": 60, "end": 64}, {"text": "DNA repair enzyme", "start": 83, "end": 100}, {"text": "redox factor 1", "start": 102, "end": 116}, {"text": "Ref-1", "start": 118, "end": 123}, {"text": "DNA repair enzyme", "start": 150, "end": 167}, {"text": "AP endonuclease", "start": 169, "end": 184}]}}, "schema": []}
{"input": "Having an LRR domain and an SH3-binding domain, Acan125 and the C. elegans homologue define a novel family of bifunctional binding proteins.", "output": {"entities": {"gene": [{"text": "LRR domain", "start": 10, "end": 20}, {"text": "SH3-binding domain", "start": 28, "end": 46}, {"text": "Acan125", "start": 48, "end": 55}]}}, "schema": []}
{"input": "However, its participation in gagging induced by oropharyngeal irritation is unclear.", "output": {"entities": {}}, "schema": []}
{"input": "The capacity to repair 8-OxoG has been measured in cell-free extracts of wild-type and ogg1 strains using a 34mer DNA fragment containing a single 8-OxoG residue paired with a cytosine (8-OxoG/C) as a substrate.", "output": {"entities": {"gene": [{"text": "ogg1", "start": 87, "end": 91}]}}, "schema": []}
{"input": "Results from our and other laboratories have suggested that UCN-01 induces preferential G1-phase accumulation in several human tumor cell lines tested.", "output": {"entities": {}}, "schema": []}
{"input": "Northern and RT-PCR analysis of Ube3a expression in mouse tissues from animals with segmental, paternal uniparental disomy failed to detect substantially reduced or absent expression compared to control animals, failing to provide any evidence for maternal-specific expression from this locus.", "output": {"entities": {"gene": [{"text": "Ube3a", "start": 32, "end": 37}]}}, "schema": []}
{"input": "Two predominant effects were noted: (i) the Xaa residue in the dual phosphorylation motif Thr-Xaa-Tyr as well as the length of L12 influence p38 substrate specificity, and (ii) the length of L12 plays a major role in controlling autophosphorylation.", "output": {"entities": {"gene": [{"text": "p38", "start": 141, "end": 144}]}}, "schema": []}
{"input": "A novel, testis-specific mRNA transcript encoding an NH2-terminal truncated nitric-oxide synthase. mRNA diversity represents a major theme of neuronal nitric-oxide synthase (nNOS) gene expression in somatic cells/tissues.", "output": {"entities": {"gene": [{"text": "testis-specific mRNA transcript", "start": 9, "end": 40}, {"text": "NH2-terminal truncated nitric-oxide synthase", "start": 53, "end": 97}, {"text": "neuronal nitric-oxide synthase", "start": 142, "end": 172}, {"text": "nNOS", "start": 174, "end": 178}]}}, "schema": []}
{"input": "Unlike the MAR-binding domain, the homeodomain when isolated binds poorly and with low specificity to DNA.", "output": {"entities": {"gene": [{"text": "homeodomain", "start": 35, "end": 46}]}}, "schema": []}
{"input": "Cyclin D1 could not be displaced from cdk4 in the resistant 184A1L5R cell lysates.", "output": {"entities": {"gene": [{"text": "Cyclin D1", "start": 0, "end": 9}, {"text": "cdk4", "start": 38, "end": 42}]}}, "schema": []}
{"input": "The importance of posttranslational regulation of p15INK4B by TGF-beta is underlined by the observation that in TGF-beta-resistant 184A1L5R, although the p15 transcript increased, p15INK4B protein was not stabilized and did not accumulate, and cyclin D1-cdk association and kinase activation were not inhibited.", "output": {"entities": {"gene": [{"text": "p15INK4B", "start": 50, "end": 58}, {"text": "TGF-beta", "start": 62, "end": 70}, {"text": "TGF-beta", "start": 112, "end": 120}, {"text": "p15 transcript", "start": 154, "end": 168}, {"text": "p15INK4B protein", "start": 180, "end": 196}, {"text": "cyclin D1", "start": 244, "end": 253}, {"text": "cdk", "start": 254, "end": 257}]}}, "schema": []}
{"input": "To identify cis-acting elements that target c-myc mRNA for downregulation during myogenesis, we stably transfected C2C12 cells with mutant myc genes or chimeric genes in which various myc sequences were fused to the human beta-globin gene or to the bacterial chloramphenicol acetyltransferase (CAT) gene.", "output": {"entities": {"gene": [{"text": "c-myc mRNA", "start": 44, "end": 54}, {"text": "mutant myc genes", "start": 132, "end": 148}, {"text": "myc sequences", "start": 184, "end": 197}, {"text": "human beta-globin gene", "start": 216, "end": 238}, {"text": "bacterial chloramphenicol acetyltransferase", "start": 249, "end": 292}, {"text": "CAT", "start": 294, "end": 297}]}}, "schema": []}
{"input": "Furthermore, experiments with 32D temperature-sensitive p53 cells indicate that aberrant tal-1 expression at the permissive temperature does not exert a proliferative effect but causes p53-mediated apoptosis, i. e., the tal-1 proliferative effect depends on the integrity of the cell cycle checkpoints of the host cell, as observed for c-myc and other oncogenes. tal-1 mutant experiments indicate that ectopic tal-1 effects are mediated by both the DNA-binding and the heterodimerization domains, while the N-terminally truncated tal-1 variant (M3) expressed in T-ALL malignant cells mimics the effects of the wild-type protein.", "output": {"entities": {"gene": [{"text": "p53", "start": 56, "end": 59}, {"text": "tal-1", "start": 89, "end": 94}, {"text": "p53", "start": 185, "end": 188}, {"text": "tal-1", "start": 220, "end": 225}, {"text": "c-myc", "start": 336, "end": 341}, {"text": "tal-1 mutant", "start": 363, "end": 375}, {"text": "tal-1", "start": 410, "end": 415}, {"text": "N-terminally truncated tal-1 variant", "start": 507, "end": 543}, {"text": "M3", "start": 545, "end": 547}]}}, "schema": []}
{"input": "DNA-binding activity was not increased by the addition of forskolin to thecal or luteal cells.", "output": {"entities": {}}, "schema": []}
{"input": "However, in some of them either pattern may predominate or be exclusively present.", "output": {"entities": {}}, "schema": []}
{"input": "Upon induction of SOS, viability increased 2-6-fold.", "output": {"entities": {}}, "schema": []}
{"input": "In particular, Western, supershift, and promoter deletion analyses suggested a role for CCAAT/enhancer-binding protein-beta (C/EBP-beta) binding site between-2010 and-1954 in regulating transcription of collagenase-1 in monocytic cells.", "output": {"entities": {"gene": [{"text": "CCAAT/enhancer-binding protein-beta", "start": 88, "end": 123}, {"text": "C/EBP-beta", "start": 125, "end": 135}, {"text": "collagenase-1", "start": 203, "end": 216}]}}, "schema": []}
{"input": "11-Aminoundecanoyl-SK-NH2 and 11-aminoundecanoyl-SH-NH2 establish that a simple alkyl backbone can maintain an appropriate distance between three elements critical for recognition by the fungal enzyme' s peptide-binding site: a simple omega-terminal amino group, a beta-hydroxyl, and an epsilon-amino group or an imidazole.", "output": {"entities": {}}, "schema": []}
{"input": "Cdc2 co-precipitates with Pch1 in S. pombe cell lysates, although Cdc2 may not be the major catalytic partner of a Pch1 kinase in vivo.", "output": {"entities": {"gene": [{"text": "Cdc2", "start": 0, "end": 4}, {"text": "Pch1", "start": 26, "end": 30}, {"text": "Cdc2", "start": 66, "end": 70}, {"text": "Pch1 kinase", "start": 115, "end": 126}]}}, "schema": []}
{"input": "Little is known about the mechanism, but the availability of rapid facile assays for monitoring immunoglobulin hypermutation would greatly aid the development of culture systems for hypermutating B cells as well as the screening for individuals deficient in the process.", "output": {"entities": {"gene": [{"text": "immunoglobulin", "start": 96, "end": 110}]}}, "schema": []}
{"input": "Expression of the human heat shock protein 70 gene (hsp70) is induced by various kinds of stress and by oncogenes.", "output": {"entities": {"gene": [{"text": "human heat shock protein 70 gene", "start": 18, "end": 50}, {"text": "hsp70", "start": 52, "end": 57}]}}, "schema": []}
{"input": "Of these proteins, five have previously been shown to be phosphorylated during mitosis (epithelial-microtubule associated protein-115, Oct91, Elongation factor 1gamma, BRG1 and Ribosomal protein L18A), five are related to proteins postulated to have roles in mitosis (epithelial-microtubule associated protein-115, Schizosaccharomyces pombe Cdc5, innercentrosome protein, BRG1 and the RNA helicase WM6), and nine are related to transcription factors (BRG1, negative co-factor 2alpha, Oct91, S. pombe Cdc5, HoxD1, Sox3, Vent2, and two isoforms of Xbr1b).", "output": {"entities": {"gene": [{"text": "epithelial-microtubule associated protein-115", "start": 88, "end": 133}, {"text": "Oct91", "start": 135, "end": 140}, {"text": "Elongation factor 1gamma", "start": 142, "end": 166}, {"text": "BRG1", "start": 168, "end": 172}, {"text": "Ribosomal protein L18A", "start": 177, "end": 199}, {"text": "epithelial-microtubule associated protein-115", "start": 268, "end": 313}, {"text": "Schizosaccharomyces pombe Cdc5", "start": 315, "end": 345}, {"text": "innercentrosome protein", "start": 347, "end": 370}, {"text": "BRG1", "start": 372, "end": 376}, {"text": "RNA helicase WM6", "start": 385, "end": 401}, {"text": "BRG1", "start": 451, "end": 455}, {"text": "negative co-factor 2alpha", "start": 457, "end": 482}, {"text": "Oct91", "start": 484, "end": 489}, {"text": "Cdc5", "start": 500, "end": 504}, {"text": "HoxD1", "start": 506, "end": 511}, {"text": "Sox3", "start": 513, "end": 517}, {"text": "Vent2", "start": 519, "end": 524}, {"text": "Xbr1b", "start": 546, "end": 551}]}}, "schema": []}
{"input": "Thus, depending on their location, psoralen cross-links affected different steps in the initiation process.", "output": {"entities": {}}, "schema": []}
{"input": "Activation of alpha 4 beta 1 with TS2/16 inhibited the cytoplasmic protrusions and cell migration but did not affect the pattern of phosphorylation.", "output": {"entities": {"gene": [{"text": "alpha 4 beta 1", "start": 14, "end": 28}, {"text": "TS2/16", "start": 34, "end": 40}]}}, "schema": []}
{"input": "Performance on two verbal measures-the National Adult Reading Test-Revised (NART-R) and the Vocabulary subtest from the Wechsler Adult Intelligence Scale-Revised (WAIS-R)-showed strong correlations with level of education.", "output": {"entities": {}}, "schema": []}
{"input": "L-canavanine, a selective inhibitor of the inducible nitric oxide synthase, increases the mean systemic filling pressure, thereby improving venous return, under these conditions.", "output": {"entities": {"gene": [{"text": "nitric oxide synthase", "start": 53, "end": 74}]}}, "schema": []}
{"input": "RESULTS: Of the 29 patients who received concurrent chemotherapy and G-CSF, ten (34%; 95% confidence interval [CI], 17. 9 to 54. 3%) were believed to have clinically significant bleomycin toxicity.", "output": {"entities": {"gene": [{"text": "G-CSF", "start": 69, "end": 74}]}}, "schema": []}
{"input": "The exonic sequence encodes a protein of 495 amino acids that is nearly identical to the previously reported protein sequence of human GPT-1.", "output": {"entities": {"gene": [{"text": "human GPT-1", "start": 129, "end": 140}]}}, "schema": []}
{"input": "Here we characterize an S. cerevisiae Swi3 homolog (Swh3) and present evidence that it associates in a complex with a Snf2 homolog, Sthl.", "output": {"entities": {"gene": [{"text": "S. cerevisiae Swi3 homolog", "start": 24, "end": 50}, {"text": "Swh3", "start": 52, "end": 56}, {"text": "Snf2 homolog", "start": 118, "end": 130}, {"text": "Sthl", "start": 132, "end": 136}]}}, "schema": []}
{"input": "Shc stimulates Ras/mitogen-activated protein kinase (MAPK) through forming a complex with Grb2 at the phosphorylated tyrosine (Y) residue 317.", "output": {"entities": {"gene": [{"text": "Shc", "start": 0, "end": 3}, {"text": "Ras", "start": 15, "end": 18}, {"text": "mitogen-activated protein kinase", "start": 19, "end": 51}, {"text": "MAPK", "start": 53, "end": 57}, {"text": "Grb2", "start": 90, "end": 94}]}}, "schema": []}
{"input": "In contrast, Y239/240F Shc, but not Y317F Shc, reduced the EGF-induced c-myc message.", "output": {"entities": {"gene": [{"text": "Y239/240F Shc", "start": 13, "end": 26}, {"text": "Y317F Shc", "start": 36, "end": 45}, {"text": "EGF", "start": 59, "end": 62}, {"text": "c-myc", "start": 71, "end": 76}]}}, "schema": []}
{"input": "The Ras guanine nucleotide-binding protein functions as a molecular switch in signalling downstream of protein-tyrosine kinases.", "output": {"entities": {"gene": [{"text": "Ras guanine nucleotide-binding protein", "start": 4, "end": 42}, {"text": "protein-tyrosine kinases", "start": 103, "end": 127}]}}, "schema": []}
{"input": "We show that Rlm1 and Smp1 have MEF2-related DNA-binding specificities: Rlm1 binds with the same specificity as MEF2, CTA (T/A) 4TAG, while SMP1 binds a more extended consensus sequence, ACTACTA (T/A) 4TAG.", "output": {"entities": {"gene": [{"text": "Rlm1", "start": 13, "end": 17}, {"text": "Smp1", "start": 22, "end": 26}, {"text": "MEF2", "start": 32, "end": 36}, {"text": "Rlm1", "start": 72, "end": 76}, {"text": "MEF2", "start": 112, "end": 116}, {"text": "CTA (T/A) 4TAG", "start": 118, "end": 132}, {"text": "SMP1", "start": 140, "end": 144}]}}, "schema": []}
{"input": "Domains I and II of B \" are buried upon assembly of the TFIIIB-DNA complex, as determined by protein footprinting.", "output": {"entities": {"gene": [{"text": "B \"", "start": 20, "end": 23}, {"text": "TFIIIB-DNA complex", "start": 56, "end": 74}]}}, "schema": []}
{"input": "Domain switch experiments reveal that C/EBP beta proteins containing either the leucine zipper or the activation domain of C/EBP alpha are unable to stimulate the 2D5 promoter yet are fully capable of transactivating an artificial promoter bearing a high-affinity C/EBP site.", "output": {"entities": {"gene": [{"text": "C/EBP beta proteins", "start": 38, "end": 57}, {"text": "C/EBP alpha", "start": 123, "end": 134}, {"text": "2D5 promoter", "start": 163, "end": 175}, {"text": "C/EBP site", "start": 264, "end": 274}]}}, "schema": []}
{"input": "PRH75, a new nucleus-localized member of the DEAD-box protein family from higher plants.", "output": {"entities": {"gene": [{"text": "PRH75", "start": 0, "end": 5}, {"text": "DEAD-box protein family", "start": 45, "end": 68}]}}, "schema": []}
{"input": "These activities are all required for stimulation of cell growth by middle-T and activate members of the MAP kinase family.", "output": {"entities": {"gene": [{"text": "middle-T", "start": 68, "end": 76}, {"text": "MAP kinase family", "start": 105, "end": 122}]}}, "schema": []}
{"input": "A role for the small GTPase Rac in polyomavirus middle-T antigen-mediated activation of the serum response element and in cell transformation.", "output": {"entities": {"gene": [{"text": "small GTPase Rac", "start": 15, "end": 31}, {"text": "polyomavirus middle-T antigen", "start": 35, "end": 64}]}}, "schema": []}
{"input": "Time-activity curves from the gastric region of interest were used, after subjection to appropriate corrective procedures, to calculate the mean gastric transit time (MTT 90) and the fraction of the test meal retained in the stomach after 90 min (F90).", "output": {"entities": {}}, "schema": []}
{"input": "This study provides a direct demonstration of a role for G betagamma in mediating the agonist-stimulated translocation of GRK2 and GRK3 in an intact cellular system and demonstrates isoform specificity in the interaction of these components.", "output": {"entities": {"gene": [{"text": "G betagamma", "start": 57, "end": 68}, {"text": "GRK2", "start": 122, "end": 126}, {"text": "GRK3", "start": 131, "end": 135}]}}, "schema": []}
{"input": "Our results indicate that RA-mediated repression of the hMGP gene is due to binding of liganded RAR/RXR to a novel negative RA response element.", "output": {"entities": {"gene": [{"text": "hMGP gene", "start": 56, "end": 65}, {"text": "RAR", "start": 96, "end": 99}, {"text": "RXR", "start": 100, "end": 103}]}}, "schema": []}
{"input": "Point mutations of the five tyrosine residues in the cytoplasmic domain of the receptor were subsequently used to confirm our conclusions.", "output": {"entities": {}}, "schema": []}
{"input": "We describe a novel method using Saccharomyces cerevisiae for detecting protein-truncating mutations in any gene of interest.", "output": {"entities": {}}, "schema": []}
{"input": "Hepatocellular injury during preservation of human livers with UW and HTK solution.", "output": {"entities": {}}, "schema": []}
{"input": "The electromyographically recorded responses consisted of an early R1 response in the orbicularis oculi muscle ipsilateral to the side of stimulation, a bilateral late response (ipsilateral R2 and contralateral Rc) and a third, R3 response, in the ipsilateral orbicularis oculi muscle.", "output": {"entities": {}}, "schema": []}
{"input": "The prognosis of seven patients who received ABSCT was significantly better than that of 13 patients who received conventional therapy alone.", "output": {"entities": {}}, "schema": []}
{"input": "(1994, Hum.", "output": {"entities": {}}, "schema": []}
{"input": "The pigment intensity of both melanized colonies and appressoria of CAL transformants was weaker than that of the wild type.", "output": {"entities": {}}, "schema": []}
{"input": "Malonate decarboxylation in Malonomonas rubra involves the formation of malonyl-S-[acyl-carrier protein] from acetyl-S-[acyl-carrier protein] and malonate, carboxyltransfer to a biotin protein and its decarboxylation that is coupled to delta mu Na + generation.", "output": {"entities": {"gene": [{"text": "malonyl-S-[acyl-carrier protein]", "start": 72, "end": 104}, {"text": "acetyl-S-[acyl-carrier protein]", "start": 110, "end": 141}, {"text": "biotin protein", "start": 178, "end": 192}]}}, "schema": []}
{"input": "The Jem peptide sequence shows a' leucine-zipper' dimerisation motif with limited homology to Fos/Jun and ATF/CREB proteins and several putative phosphorylation sites.", "output": {"entities": {"gene": [{"text": "Jem", "start": 4, "end": 7}, {"text": "Fos", "start": 94, "end": 97}, {"text": "Jun", "start": 98, "end": 101}, {"text": "ATF", "start": 106, "end": 109}, {"text": "CREB", "start": 110, "end": 114}]}}, "schema": []}
{"input": "Here we report the cloning of the protein that binds to enhancer site III.", "output": {"entities": {}}, "schema": []}
{"input": "Further support for a direct interaction of Tub4p, Spc98p and Spc97p comes from the toxicity of strong SPC97 overexpression which is suppressed by co-overexpression of TUB4 or SPC98.", "output": {"entities": {"gene": [{"text": "Tub4p", "start": 44, "end": 49}, {"text": "Spc98p", "start": 51, "end": 57}, {"text": "Spc97p", "start": 62, "end": 68}, {"text": "SPC97", "start": 103, "end": 108}, {"text": "TUB4", "start": 168, "end": 172}, {"text": "SPC98", "start": 176, "end": 181}]}}, "schema": []}
{"input": "Sequences needed for iron-regulated expression of sid1 were localized to a 306 bp region mapping 2. 3 and 2. 6 kb upstream of the ATG.", "output": {"entities": {"gene": [{"text": "sid1", "start": 50, "end": 54}]}}, "schema": []}
{"input": "Comparison of the p50 sequence to other cloned proteins revealed 89% homology with a glycosaminoglycan-binding protein and 54% homology with Drosophila cell cycle control protein (cdc) 37.", "output": {"entities": {"gene": [{"text": "p50 sequence", "start": 18, "end": 30}, {"text": "Drosophila cell cycle control protein (cdc)", "start": 141, "end": 184}]}}, "schema": []}
{"input": "Additional information including echocardiographic sequences, perioperative video sequences, x-ray analysis, angiograms, etc. is represented in the program.", "output": {"entities": {}}, "schema": []}
{"input": "We report here that constitutively active Mek1 could activate p96h2bk in the absence of oncogenic Ras.", "output": {"entities": {"gene": [{"text": "Mek1", "start": 42, "end": 46}, {"text": "p96h2bk", "start": 62, "end": 69}, {"text": "oncogenic Ras", "start": 88, "end": 101}]}}, "schema": []}
{"input": "In Schizosaccharomyces pombe, the activity of the M-phase-inducing Cdc2/Cdc13 cyclin-dependent kinase is inhibited by Wee1 and Mik1 tyrosine kinases, and activated by Cdc25 and Pyp3 tyrosine phosphatases.", "output": {"entities": {"gene": [{"text": "Cdc2", "start": 67, "end": 71}, {"text": "Cdc13", "start": 72, "end": 77}, {"text": "Wee1", "start": 118, "end": 122}, {"text": "Mik1 tyrosine kinases", "start": 127, "end": 148}, {"text": "Cdc25", "start": 167, "end": 172}, {"text": "Pyp3 tyrosine phosphatases", "start": 177, "end": 203}]}}, "schema": []}
{"input": "The sequencing of Stellate copies located along the discontinuous cluster revealed a complex pattern of diversification.", "output": {"entities": {"gene": [{"text": "Stellate", "start": 18, "end": 26}]}}, "schema": []}
{"input": "The results indicate that DNA methylation, chromatin structure, and transactivation at an Sp1 site contribute to the highly restricted expression of this myelomonocytic lineage specific gene.", "output": {"entities": {"gene": [{"text": "Sp1 site", "start": 90, "end": 98}]}}, "schema": []}
{"input": "In gel mobility shift assays, factors present in nuclear extracts derived from differentiated osteoblast bound to oligonucleotide probes containing the E-box 1 and E-box 2 elements.", "output": {"entities": {}}, "schema": []}
{"input": "Laboratory exam: IDR of the tuberculin was high positive, chest radiography shows hilar bilateral calcifications, ORL exam shows a tumor at the foot of the epiglottis and anatomopathological exam shows low differentiated epidermoid carcinoma.", "output": {"entities": {"gene": [{"text": "tuberculin", "start": 28, "end": 38}]}}, "schema": []}
{"input": "Finally, we show that PhLP complexes, at least partially, with Gbetagamma in vivo.", "output": {"entities": {"gene": [{"text": "PhLP", "start": 22, "end": 26}, {"text": "Gbetagamma", "start": 63, "end": 73}]}}, "schema": []}
{"input": "CTF1alpha, expressed in Escherichia coli, showed specific binding to the palindrome 2 DNA fragment but not to palindrome 1 or mutant palindrome 2 DNA fragments, suggesting specific binding of CTF1alpha to palindrome 2.", "output": {"entities": {"gene": [{"text": "CTF1alpha", "start": 0, "end": 9}, {"text": "CTF1alpha", "start": 192, "end": 201}]}}, "schema": []}
{"input": "Cyclin G2 is highly expressed in the immune system where immunologic tolerance subjects self-reactive lymphocytes to negative selection and clonal deletion via apoptosis.", "output": {"entities": {"gene": [{"text": "Cyclin G2", "start": 0, "end": 9}]}}, "schema": []}
{"input": "A sterol-regulated protease initiates release of the NH2-terminal segments of sterol regulatory element-binding proteins (SREBPs) from cell membranes, thereby allowing them to enter the nucleus and to stimulate transcription of genes involved in the uptake and synthesis of cholesterol and fatty acids.", "output": {"entities": {"gene": [{"text": "sterol regulatory element-binding proteins", "start": 78, "end": 120}, {"text": "SREBPs", "start": 122, "end": 128}]}}, "schema": []}
{"input": "Thus, the P. aeruginosa orfX and vfr promoters are arranged in a back-to-back orientation rather than the face-to-face orientation of the dorf and crp promoters.", "output": {"entities": {"gene": [{"text": "vfr promoters", "start": 33, "end": 46}, {"text": "crp promoters", "start": 147, "end": 160}]}}, "schema": []}
{"input": "Sequence analysis of cloned PCR products confirmed the presence of two different nifV-like DNA fragments, which were subsequently used as nifV-and leuA-specific probes, respectively, to clone XbaI fragments of 2. 1 kbp (pOST4) and 2. 6 kbp (pOST2).", "output": {"entities": {"gene": [{"text": "nifV-like DNA fragments", "start": 81, "end": 104}, {"text": "nifV", "start": 138, "end": 142}, {"text": "leuA-specific probes", "start": 147, "end": 167}, {"text": "XbaI fragments", "start": 192, "end": 206}]}}, "schema": []}
{"input": "In contrast, the Anabaena strain 7120 leuA gene did not complement the nifV mutation of R229I efficiently.", "output": {"entities": {"gene": [{"text": "leuA", "start": 38, "end": 42}, {"text": "nifV mutation", "start": 71, "end": 84}]}}, "schema": []}
{"input": "(3) This effect occurs without removing TRs from the TRE.", "output": {"entities": {"gene": [{"text": "TRs", "start": 40, "end": 43}]}}, "schema": []}
{"input": "In a model of the ternary complex, the segment of NFAT nearest AP-1 is the Rel insert region (RIR), a feature that is notable for its hypervariability in size and in sequence amongst members of the Rel transcription factor family.", "output": {"entities": {"gene": [{"text": "NFAT", "start": 50, "end": 54}, {"text": "AP-1", "start": 63, "end": 67}, {"text": "Rel", "start": 75, "end": 78}, {"text": "Rel transcription factor family", "start": 198, "end": 229}]}}, "schema": []}
{"input": "We thus conclude that the NFAT RIR plays an essential dual role in DNA recognition and cooperative binding to AP-1 family transcription factors.", "output": {"entities": {"gene": [{"text": "NFAT RIR", "start": 26, "end": 34}, {"text": "AP-1 family transcription factors", "start": 110, "end": 143}]}}, "schema": []}
{"input": "Thus, the association of PS1 fragments may be maintained during cycles of phosphorylation/dephosphorylation of the PS1 CTF.", "output": {"entities": {"gene": [{"text": "PS1 fragments", "start": 25, "end": 38}, {"text": "PS1 CTF", "start": 115, "end": 122}]}}, "schema": []}
{"input": "This protein can bind to a region of the promoter of an Arabidopsis light-harvesting chlorophyll a/b protein gene, Lhcb1 * 3, which is necessary for its regulation by phytochrome.", "output": {"entities": {"gene": [{"text": "Arabidopsis light-harvesting chlorophyll a/b protein gene", "start": 56, "end": 113}, {"text": "Lhcb1 * 3", "start": 115, "end": 124}, {"text": "phytochrome", "start": 167, "end": 178}]}}, "schema": []}
{"input": "A patient of Group B had severe athetoid CP with spasticity, being unable to right his trunk and neck.", "output": {"entities": {}}, "schema": []}
{"input": "Dystonic movement of the left upper limb in a case of the right pontine hemorrhage", "output": {"entities": {}}, "schema": []}
{"input": "It has repeatedly been shown that HCMV IE1/IE2 can independently transactivate HIV-1 LTR.", "output": {"entities": {"gene": [{"text": "IE1", "start": 39, "end": 42}, {"text": "IE2", "start": 43, "end": 46}, {"text": "HIV-1 LTR", "start": 79, "end": 88}]}}, "schema": []}
{"input": "TAR and Sp1-independent transactivation of HIV long terminal repeat by the Tat protein in the presence of human cytomegalovirus IE1/IE2.", "output": {"entities": {"gene": [{"text": "TAR", "start": 0, "end": 3}, {"text": "Sp1", "start": 8, "end": 11}, {"text": "HIV long terminal repeat", "start": 43, "end": 67}, {"text": "Tat protein", "start": 75, "end": 86}, {"text": "IE1", "start": 128, "end": 131}, {"text": "IE2", "start": 132, "end": 135}]}}, "schema": []}
{"input": "Respiratory chain enzyme activity was normal.", "output": {"entities": {}}, "schema": []}
{"input": "Cellular Csk was associated with several phosphoproteins, some of which were interacting with the Csk SH2 domain.", "output": {"entities": {"gene": [{"text": "Cellular Csk", "start": 0, "end": 12}, {"text": "Csk SH2 domain", "start": 98, "end": 112}]}}, "schema": []}
{"input": "Thus, our studies suggest that pV-mediated activation of HIV-1 LTR activity is controlled by the nuclear translocation of the NF-kappaB transcription factor, which is mediated by IkappaBalpha serine phosphorylation and degradation, but also by a still undefined NF-kappaB-independent pathway.", "output": {"entities": {"gene": [{"text": "HIV-1 LTR", "start": 57, "end": 66}, {"text": "NF-kappaB transcription factor", "start": 126, "end": 156}, {"text": "IkappaBalpha", "start": 179, "end": 191}, {"text": "NF-kappaB", "start": 262, "end": 271}]}}, "schema": []}
{"input": "FN-stimulated c-Src PTK activity was enhanced by wild type FAK expression, whereas FN-stimulated activation of ERK2 was blocked by expression of the c-Src binding site Phe-397 mutant of FAK.", "output": {"entities": {"gene": [{"text": "FN", "start": 0, "end": 2}, {"text": "c-Src PTK", "start": 14, "end": 23}, {"text": "FAK", "start": 59, "end": 62}, {"text": "FN", "start": 83, "end": 85}, {"text": "ERK2", "start": 111, "end": 115}, {"text": "c-Src binding site Phe-397 mutant", "start": 149, "end": 182}, {"text": "FAK", "start": 186, "end": 189}]}}, "schema": []}
{"input": "A promising new cement, 4-META/MMA-TBB opaque resin, has shown remarkable adhesive properties as a bone cement in vivo.", "output": {"entities": {}}, "schema": []}
{"input": "Each sample was analysed as soon as possible, and repeated 15, 30, 60 and 120 min after sampling.", "output": {"entities": {}}, "schema": []}
{"input": "Like the elicitors of the hypersensitive reaction (HR) produced by E. chrysanthemi (HarpinEch) and E. amylovora (HarpinEa), the deduced 36-kDa protein does not possess a typical signal sequence, but it contains a putative membrane-spanning domain.", "output": {"entities": {}}, "schema": []}
{"input": "Molecular characterization and expression of the Erwinia carotovora hrpNEcc gene, which encodes an elicitor of the hypersensitive reaction.", "output": {"entities": {"gene": [{"text": "Erwinia carotovora hrpNEcc gene", "start": 49, "end": 80}]}}, "schema": []}
{"input": "The mRNA from this gene, termed HES1, is ubiquitously expressed, but strongly so in heart and skeletal muscle.", "output": {"entities": {"gene": [{"text": "HES1", "start": 32, "end": 36}]}}, "schema": []}
{"input": "Anesthesia was maintained with isoflurane (ISO)/N2O/O2 inhalation.", "output": {"entities": {}}, "schema": []}
{"input": "They observed depressed protein C activity that significantly (p < 0. 005) increased and became normal immediately after hemodialysis while factor X and factor VII increased (p < 0. 01; p < 0. 05) despite heparinization together with amount of serum lipoprotein (a).", "output": {"entities": {"gene": [{"text": "protein C", "start": 24, "end": 33}, {"text": "factor X", "start": 140, "end": 148}, {"text": "factor VII", "start": 153, "end": 163}, {"text": "serum lipoprotein (a)", "start": 244, "end": 265}]}}, "schema": []}
{"input": "We present a case of type II hyperbetalipoproteinemia in a patient whose diagnosis had been previously unrecognized, and who had previously been misdiagnosed with rheumatoid arthritis and later gout.", "output": {"entities": {}}, "schema": []}
{"input": "These data provide evidence that the 2. 0-kb LAT is an intron of the mLAT pre-mRNA with a unique branch point.", "output": {"entities": {"gene": [{"text": "2. 0-kb LAT", "start": 37, "end": 48}, {"text": "mLAT pre-mRNA", "start": 69, "end": 82}]}}, "schema": []}
{"input": "The altered amino acid residues of the seven mutant 9ORF1 polypeptides clustered within three separate regions referred to as region I (residues 34 to 41), region II (residues 89 to 91), and C-terminal region III (residues 122 to 125).", "output": {"entities": {"gene": [{"text": "mutant 9ORF1 polypeptides", "start": 45, "end": 70}]}}, "schema": []}
{"input": "Rep-Rep protein interaction was confirmed in vitro through coimmunoprecipitation experiments with a bacterially expressed maltose-binding protein-Rep78 fusion protein in combination with [35S] methionine-labeled Rep78 synthesized in a coupled in vitro transcription-translation system.", "output": {"entities": {"gene": [{"text": "Rep", "start": 0, "end": 3}, {"text": "Rep", "start": 4, "end": 7}, {"text": "maltose-binding protein", "start": 122, "end": 145}, {"text": "Rep78", "start": 146, "end": 151}, {"text": "Rep78", "start": 212, "end": 217}]}}, "schema": []}
{"input": "Fourteen patients with New York Heart Association class II congestive heart failure were enrolled in a double-blind, cross-over study.", "output": {"entities": {}}, "schema": []}
{"input": "The main advantages of Multi-MUP analysis are: (1) quick acquisition of many MUPs; (2) simultaneous collection of several MUPs at one recording site; (3) possibility to analyze not only low threshold MUPs; (4) less bias in the selection of MUPs and (5) the reproducibility of the results that allow the same reference values to be used in different laboratories.", "output": {"entities": {}}, "schema": []}
{"input": "In several studies the RDFS has shown evidence of reliability and validity.", "output": {"entities": {}}, "schema": []}
{"input": "These results suggest that dietary safflower phospholipids may be a valuable ingredient to layers for reducing liver triglycerides and serum cholesterol without any adverse effects.", "output": {"entities": {}}, "schema": []}
{"input": "Using various techniques, we have undertaken a systematic analysis of the natural TATA-less human DNA polymerase beta (beta-pol) gene promoter.", "output": {"entities": {"gene": [{"text": "human DNA polymerase beta", "start": 92, "end": 117}, {"text": "beta-pol", "start": 119, "end": 127}]}}, "schema": []}
{"input": "Saturable spermidine transport in stk2:: lacZ mutants had an approximately fivefold-lower affinity and twofold-lower Vmax than in the parental strain.", "output": {"entities": {"gene": [{"text": "stk2", "start": 34, "end": 38}, {"text": "lacZ mutants", "start": 41, "end": 53}]}}, "schema": []}
{"input": "Inhibition of the Raf-1 kinase by cyclic AMP agonists causes apoptosis of v-abl-transformed cells.", "output": {"entities": {"gene": [{"text": "Raf-1 kinase", "start": 18, "end": 30}, {"text": "v-abl", "start": 74, "end": 79}]}}, "schema": []}
{"input": "Previous studies have indicated that a hamster cell line (ts13) with a point mutation in the TAF (II) 250/CCG1 (TAF (II) 250) gene shows temperature-sensitive expression of a subset of genes and arrests in late G1 at 39. 5 degrees C.", "output": {"entities": {"gene": [{"text": "TAF (II) 250", "start": 93, "end": 105}, {"text": "CCG1", "start": 106, "end": 110}, {"text": "TAF (II) 250", "start": 112, "end": 124}]}}, "schema": []}
{"input": "We show here that the protein kinase MEKK1 can induce reporter gene expression from the atrial natriuretic factor (ANF) promoter, a genetic marker that is activated during in vivo hypertrophy.", "output": {"entities": {"gene": [{"text": "MEKK1", "start": 37, "end": 42}, {"text": "atrial natriuretic factor", "start": 88, "end": 113}, {"text": "ANF", "start": 115, "end": 118}]}}, "schema": []}
{"input": "Overexpression of EFG1 in C. albicans leads to enhanced filamentous growth in the form of extended pseudohyphae in liquid and on solid media.", "output": {"entities": {"gene": [{"text": "EFG1", "start": 18, "end": 22}]}}, "schema": []}
{"input": "To determine if signing, when established, would compete with SIB when both were reinforced, extinction was then withdrawn.", "output": {"entities": {}}, "schema": []}
{"input": "The husband in one of the married couples was treated for hepatitis of unidentified etiology in an Infectology Department four years ago.", "output": {"entities": {}}, "schema": []}
{"input": "Both quantitative and qualitative analysis of individual cytoarchitectonic peculiarities of Meynart' s nucleus as well as of external part of dorsomedial nucleus of thalamus was performed in mentally normal individuals.", "output": {"entities": {}}, "schema": []}
{"input": "Positional cloning has already produced the sequences of more than 70 human genes associated with specific diseases.", "output": {"entities": {}}, "schema": []}
{"input": "The 30-day mortality in the CPB group and the non-CPB group were 20% and 4. 6%, respectively which was not statistically significant (p = 0. 06).", "output": {"entities": {}}, "schema": []}
{"input": "As opposed to in vitro co-precipitation studies, the yeast two-hybrid screen reveals in vivo protein-protein interactions.", "output": {"entities": {}}, "schema": []}
{"input": "This association appears to be mediated by Src-SH2 domain, because PECAM-1 can be precipitated by a GST-Src-SH2 affinity matrix.", "output": {"entities": {"gene": [{"text": "Src", "start": 43, "end": 46}, {"text": "SH2", "start": 47, "end": 50}, {"text": "PECAM-1", "start": 67, "end": 74}, {"text": "GST", "start": 100, "end": 103}, {"text": "Src", "start": 104, "end": 107}, {"text": "SH2", "start": 108, "end": 111}]}}, "schema": []}
{"input": "MKK3 autophosphorylation and activation of p38 was also observed following coexpression of MKK3 with MEKK3, but not with MEKK2.", "output": {"entities": {"gene": [{"text": "MKK3", "start": 0, "end": 4}, {"text": "p38", "start": 43, "end": 46}, {"text": "MKK3", "start": 91, "end": 95}, {"text": "MEKK3", "start": 101, "end": 106}, {"text": "MEKK2", "start": 121, "end": 126}]}}, "schema": []}
{"input": "An alternatively spliced MAdCAM-1 variant was identified that lacks exon 4 encoding the mucin domain, and may mediate leukocyte adhesion to LPAM-1 without adhesion to the alternate receptor, L-selectin.", "output": {"entities": {"gene": [{"text": "MAdCAM-1", "start": 25, "end": 33}, {"text": "mucin", "start": 88, "end": 93}, {"text": "LPAM-1", "start": 140, "end": 146}, {"text": "L-selectin", "start": 191, "end": 201}]}}, "schema": []}
{"input": "In summary, the data establish that the previously reported human MAdCAM-1 cDNA does indeed encode the human homologue of mouse MAdCAM-1, despite gross dissimilarities in the MAdCAM-1 C-terminal structures.", "output": {"entities": {"gene": [{"text": "human MAdCAM-1 cDNA", "start": 60, "end": 79}, {"text": "mouse MAdCAM-1", "start": 122, "end": 136}, {"text": "MAdCAM-1", "start": 175, "end": 183}]}}, "schema": []}
{"input": "We have used a site-directed mutagenesis approach to examine how the Xaa and hydroxy (Ser/Thr) amino acid residues in sequons influence core-glycosylation efficiency.", "output": {"entities": {}}, "schema": []}
{"input": "MATERIAL AND METHODS: The authors analyzed 41 persons formerly submitted to surgery (after 8 years and 4 months, as a mean), 31 to highly selective vagotomy, and 10 to truncal or selective vagotomy plus gastroduodenal drainage.", "output": {"entities": {}}, "schema": []}
{"input": "This region does not contain an identifiable TATA element, indicating that transcription of the glutaminase gene is driven by a TATA-less promoter.", "output": {"entities": {"gene": [{"text": "glutaminase gene", "start": 96, "end": 112}]}}, "schema": []}
{"input": "Serum alkaline phosphatase activity, bone mass measurements, dual energy x-ray absortiometric analysis of mineral density, and mechanical testing values in vertebrae and femora of the-D Sal animals did not significantly differ from those in + D Sal animals.", "output": {"entities": {"gene": [{"text": "Serum alkaline phosphatase", "start": 0, "end": 26}]}}, "schema": []}
{"input": "The monkey LHR cDNA displayed 83-94% overall sequence homology with the other mammalian LHR cDNAs.", "output": {"entities": {"gene": [{"text": "monkey LHR cDNA", "start": 4, "end": 19}, {"text": "mammalian LHR cDNAs", "start": 78, "end": 97}]}}, "schema": []}
{"input": "In conclusion, marmoset monkey LHR seems to lack the sequence corresponding to exon 10 of the LHR gene in other mammalian species.", "output": {"entities": {"gene": [{"text": "marmoset monkey LHR", "start": 15, "end": 34}, {"text": "LHR gene", "start": 94, "end": 102}]}}, "schema": []}
{"input": "In unc-4 mutants, VA motor neurons assume the pattern of synaptic input normally reserved for their lineal sister cells, the VB motor neurons; the loss of normal input to the VAs produces a distinctive backward movement defect.", "output": {"entities": {"gene": [{"text": "unc-4 mutants", "start": 3, "end": 16}]}}, "schema": []}
{"input": "Intracavitary irradiation was carried out with a microSelectron HDR afterloading device and usually 22. 5 Gy was given in three fractions repeated weekly.", "output": {"entities": {}}, "schema": []}
{"input": "No patient in group 2 developed HAT (P = 0. 006 versus group 1).", "output": {"entities": {}}, "schema": []}
{"input": "Sequence comparison of the 0. 38 kb promoter sequence with the promoters of the Sm-E gene and U1 snRNA genes revealed several homologous motifs, suggesting that genes encoding the snRNP components may be coordinately regulated.", "output": {"entities": {"gene": [{"text": "Sm-E", "start": 80, "end": 84}, {"text": "U1 snRNA genes", "start": 94, "end": 108}]}}, "schema": []}
{"input": "METHODS: The responses of a 31-year-old woman with complex regional pain syndrome type I (reflex sympathetic dystrophy) to a thermal grill were evaluated before and after stellate ganglion block.", "output": {"entities": {}}, "schema": []}
{"input": "More recently, however, a number of developments such as the successful use of the inhaled steroid budesonide and oral dexamethasone have reinforced the argument for using steroids.", "output": {"entities": {}}, "schema": []}
{"input": "In AcMNPV-infected Sf9 cells, late transcription initiation is detected from only two upstream TAAG sites and not from three downstream TAAG sites.", "output": {"entities": {}}, "schema": []}
{"input": "Mutation of nucleotides adjacent to the AP-1 cis-response elements had no effect on trans-activation.", "output": {"entities": {"gene": [{"text": "AP-1 cis-response elements", "start": 40, "end": 66}]}}, "schema": []}
{"input": "The close proximity of the two neuropeptide Y receptor genes suggests that they have evolved from a gene duplication event with the small intron interrupting the coding sequence of the y1 gene being converted into a functional sequence within the y5 gene, while the reverse complementary sequence was utilized as an alternatively spliced 5' exon for the y1 gene.", "output": {"entities": {"gene": [{"text": "neuropeptide Y receptor genes", "start": 31, "end": 60}, {"text": "y1 gene", "start": 185, "end": 192}, {"text": "y5 gene", "start": 247, "end": 254}, {"text": "y1 gene", "start": 354, "end": 361}]}}, "schema": []}
{"input": "The mammalian phosphoinositide 3-kinases (PI3Ks) p110alpha, beta, and delta form heterodimers with Src homology 2 (SH2) domain-containing adaptors such as p85alpha or p55 (PIK).", "output": {"entities": {"gene": [{"text": "mammalian phosphoinositide 3-kinases", "start": 4, "end": 40}, {"text": "PI3Ks", "start": 42, "end": 47}, {"text": "p110alpha, beta, and delta", "start": 49, "end": 75}, {"text": "Src homology 2", "start": 99, "end": 113}, {"text": "SH2", "start": 115, "end": 118}, {"text": "p85alpha", "start": 155, "end": 163}, {"text": "p55", "start": 167, "end": 170}, {"text": "PIK", "start": 172, "end": 175}]}}, "schema": []}
{"input": "In the studies reported here, the 5'-flanking region of the human gp130 gene was isolated and the transcription initiation sites were mapped.", "output": {"entities": {"gene": [{"text": "human gp130 gene", "start": 60, "end": 76}]}}, "schema": []}
{"input": "Localization of the cytokine response element by 5'-deletion analysis and site-directed mutagenesis revealed a cis-acting binding site for activated STAT complexes.", "output": {"entities": {"gene": [{"text": "STAT", "start": 149, "end": 153}]}}, "schema": []}
{"input": "Insulin regulation of mitogen-activated protein kinase kinase (MEK), mitogen-activated protein kinase and casein kinase in the cell nucleus: a possible role in the regulation of gene expression.", "output": {"entities": {"gene": [{"text": "Insulin", "start": 0, "end": 7}, {"text": "mitogen-activated protein kinase kinase", "start": 22, "end": 61}, {"text": "MEK", "start": 63, "end": 66}, {"text": "mitogen-activated protein kinase", "start": 69, "end": 101}, {"text": "casein kinase", "start": 106, "end": 119}]}}, "schema": []}
{"input": "Sequencing of the three pag-3 alleles showed that two apparent null alleles encode a nonsense mutation before the zinc fingers and a missense mutation in the fourth zinc finger that changes a coordinating histidine to a tyrosine.", "output": {"entities": {"gene": [{"text": "pag-3 alleles", "start": 24, "end": 37}]}}, "schema": []}
{"input": "Here, a case of Sjogren' s syndrome is presented that was initially diagnosed because of dental complaints, and long-term treatment of Sjogren' s patients is discussed.", "output": {"entities": {}}, "schema": []}
{"input": "Cloning and characterization of a cDNA encoding a bacteriophage-type RNA polymerase from the higher plant Chenopodium album.", "output": {"entities": {"gene": [{"text": "bacteriophage-type RNA polymerase", "start": 50, "end": 83}]}}, "schema": []}
{"input": "Similarly, overexpression of increasing concentration of COUP-TFI, but not COUP-TFI delta35, can squelch the silencing activity of the unliganded TRbeta.", "output": {"entities": {"gene": [{"text": "COUP-TFI", "start": 57, "end": 65}, {"text": "COUP-TFI delta35", "start": 75, "end": 91}, {"text": "TRbeta", "start": 146, "end": 152}]}}, "schema": []}
{"input": "In ciliates, both mechanisms are readily observed.", "output": {"entities": {}}, "schema": []}
{"input": "Based on the occurrence of several transcription signals in the Thermus pyr promoter region and strong amino acid sequence identities (about 60%) between Thermus PyrR and the PyrR attenuation proteins of two Bacillus sp., we propose a regulatory mechanism involving transcriptional attenuation to control pyr gene expression in Thermus.", "output": {"entities": {"gene": [{"text": "Thermus pyr promoter region", "start": 64, "end": 91}, {"text": "Thermus PyrR", "start": 154, "end": 166}, {"text": "PyrR attenuation proteins", "start": 175, "end": 200}, {"text": "pyr gene", "start": 305, "end": 313}]}}, "schema": []}
{"input": "Diver respiratory responses to a tunable closed-circuit breathing apparatus.", "output": {"entities": {}}, "schema": []}
{"input": "Measurement of the time constant of VO2 and oxygen pulse during constant work rate exercise are useful for the objective evaluation of the training effect of patients with COPD.", "output": {"entities": {}}, "schema": []}
{"input": "Characterization of CR1 repeat random PCR markers for mapping the chicken genome.", "output": {"entities": {"gene": [{"text": "CR1", "start": 20, "end": 23}]}}, "schema": []}
{"input": "A reversed-phase high-performance liquid chromatographic (HPLC) method for the determination of cocaine metabolites produced in vitro by serum and liver esterases is described.", "output": {"entities": {"gene": [{"text": "serum and liver esterases", "start": 137, "end": 162}]}}, "schema": []}
{"input": "Mutational studies provide evidence to this end and indicate that the side chains of subdomain 4. 2 make specific contacts with the nucleotides at-35.", "output": {"entities": {}}, "schema": []}
{"input": "It is concluded that fludarabine is a highly useful agent in CLL.", "output": {"entities": {}}, "schema": []}
{"input": "Three different techniques of EA analysis were used in the study: 1) fast Fourier transformation (FFT) of EA in a broad band, 2) developed by us alternative method of non-harmonic expansion of the EEG curves taking into account their shape, 3) factor analysis of the EA spectral densities.", "output": {"entities": {}}, "schema": []}
{"input": "Concomitantly, p34CDC2 histone H1 kinase activity increases in the former, but not in the latter cell lines, hence suggesting a role for this protein in radiation-induced cell death.", "output": {"entities": {"gene": [{"text": "p34CDC2 histone H1", "start": 15, "end": 33}]}}, "schema": []}
{"input": "Thus, the B-S mutant does not mimic efficiently the chloroplastic GAPDHs, and long-range and/or second-layer effects, not easily predictable from visual inspection of three-dimensional structures, need to be taken into account for designing a true \" chloroplastic-like \" mutant of cytosolic GAPDH.", "output": {"entities": {"gene": [{"text": "chloroplastic GAPDHs", "start": 52, "end": 72}, {"text": "cytosolic GAPDH", "start": 281, "end": 296}]}}, "schema": []}
{"input": "Computer software assisted ordering (CSAO) was developed to integrate PN Ca: P solubility with clinical data to improve parenteral Ca and P administration.", "output": {"entities": {}}, "schema": []}
{"input": "A similar chimera was assembled from the two halves of the molecule expressed separately in different bacteria and refolded together.", "output": {"entities": {}}, "schema": []}
{"input": "The conditions for obtaining titanium dioxide from the substrates titanium tetrachloride and oxygen and applying this to a surgical stainless steel of the type 316L by the plasma assisted chemical vapour deposition method have been determined.", "output": {"entities": {}}, "schema": []}
{"input": "All six genes were cloned and characterised.", "output": {"entities": {}}, "schema": []}
{"input": "We analysed two regions involved in preS2/S gene transcription of the HBV adw subtype: the diverged TATA box and a putative initiator element.", "output": {"entities": {"gene": [{"text": "preS2", "start": 36, "end": 41}, {"text": "S gene", "start": 42, "end": 48}]}}, "schema": []}
{"input": "Indeed the predicted folding of the 5' and 3'-untranslated regions revealed patterns of stem and loop structures conserved for all tick-borne flaviviruses suggesting a purifying selection for preservation of essential RNA secondary structures which could be involved in translational control and replication.", "output": {"entities": {}}, "schema": []}
{"input": "EGF acts primarily by means of transactivation domain AF-1, whereas cAMP acts via transactivation domain AF-2 of the ER.", "output": {"entities": {"gene": [{"text": "EGF", "start": 0, "end": 3}, {"text": "ER", "start": 117, "end": 119}]}}, "schema": []}
{"input": "To determine which region of SulA is essential for the inhibition of cell division, we constructed a series of N-terminal and C-terminal deletions of SulA and a series of alanine substitution mutants.", "output": {"entities": {"gene": [{"text": "SulA", "start": 29, "end": 33}, {"text": "SulA", "start": 150, "end": 154}]}}, "schema": []}
{"input": "We have inactivated Krox-20 by homologous recombination in ES cells and demonstrated that the mutation leads to the deletion of r3 and r5.", "output": {"entities": {"gene": [{"text": "Krox-20", "start": 20, "end": 27}]}}, "schema": []}
{"input": "Recently we have performed a detailed analysis of specific neuronal populations affected by the mutation which shed new light on the role of Krox-20 in the segmentation and on the physiological consequences of its inactivation.", "output": {"entities": {"gene": [{"text": "Krox-20", "start": 141, "end": 148}]}}, "schema": []}
{"input": "Consistent with its role in p53 ubiquitination, mE6-AP was found both in the nucleus and cytosol, while Nedd-4 was found only in the cytosol.", "output": {"entities": {"gene": [{"text": "p53", "start": 28, "end": 31}, {"text": "mE6-AP", "start": 48, "end": 54}, {"text": "Nedd-4", "start": 104, "end": 110}]}}, "schema": []}
{"input": "SPP also induced transient tyrosine phosphorylation of focal adhesion kinase (p125 (FAK)), a cytosolic tyrosine kinase that localizes in focal adhesions, and of the cytoskeleton-associated protein paxillin.", "output": {"entities": {"gene": [{"text": "SPP", "start": 0, "end": 3}, {"text": "focal adhesion kinase", "start": 55, "end": 76}, {"text": "p125", "start": 78, "end": 82}, {"text": "FAK", "start": 84, "end": 87}, {"text": "cytosolic tyrosine kinase", "start": 93, "end": 118}, {"text": "cytoskeleton-associated protein paxillin", "start": 165, "end": 205}]}}, "schema": []}
{"input": "Evaluation of myocardial perfusion by 99mTc-tetrofosmin SPECT before and after emergent percutaneous transluminal coronary angioplasty for acute myocardial infarction", "output": {"entities": {}}, "schema": []}
{"input": "A neonatal alloimmune thrombocytopenia with an HPA-3a (Baka) incompatibility was confirmed.", "output": {"entities": {"gene": [{"text": "HPA-3a", "start": 47, "end": 53}]}}, "schema": []}
{"input": "Most eukaryotic mRNAs are translated by a \" scanning ribosome \" mechanism.", "output": {"entities": {}}, "schema": []}
{"input": "Comparison of Tc-99m sestamibi perfusion imaging and echocardiography using an arbutamine infusion for the detection of coronary artery disease.", "output": {"entities": {}}, "schema": []}
{"input": "Five of these have ocular or oculocutaneous albinism.", "output": {"entities": {}}, "schema": []}
{"input": "Comprising a 126-nucleotide 5' untranscribed genomic sequence and a 466-nucleotide 5' noncoding cDNA sequence, the 592-nucleotide 5' CpG island lacked TATA and CAAT boxes but displayed a high G + C content, was enriched for CpG dinucleotides, and contained a potential Sp1-binding site, i. e., features compatible with a housekeeping gene.", "output": {"entities": {"gene": [{"text": "Sp1-binding site", "start": 269, "end": 285}]}}, "schema": []}
{"input": "SSeCKS (pronounced essex) encodes a major protein kinase C substrate, the expression of which is down-regulated in src-and ras-transformed rodent fibroblasts but not in raf-transformed rodent fibroblasts (X.", "output": {"entities": {"gene": [{"text": "SSeCKS", "start": 0, "end": 6}, {"text": "protein kinase C", "start": 42, "end": 58}, {"text": "src", "start": 115, "end": 118}, {"text": "ras", "start": 123, "end": 126}]}}, "schema": []}
{"input": "The 1. 1-and 1. 3-kb mRNA species were found only in the heart, and the 2. 6-kb species was found in the heart, kidney and brain, but not in skeletal muscle or liver.", "output": {"entities": {}}, "schema": []}
{"input": "Taurine deficiency significantly depressed the amplitude of OP1 and OP4.", "output": {"entities": {}}, "schema": []}
{"input": "We have found that mcs4-cells are defective at activation of Spc1 in response to various forms of stress.", "output": {"entities": {"gene": [{"text": "mcs4", "start": 19, "end": 23}, {"text": "Spc1", "start": 61, "end": 65}]}}, "schema": []}
{"input": "The extended rat SP-A isoforms were enriched in the more fully glycosylated and multimeric SP-A species separated on SDS-PAGE gels.", "output": {"entities": {"gene": [{"text": "rat SP-A isoforms", "start": 13, "end": 30}, {"text": "SP-A", "start": 91, "end": 95}]}}, "schema": []}
{"input": "Alternative splicing of CDC25B may therefore contribute to the control of cell proliferation.", "output": {"entities": {"gene": [{"text": "CDC25B", "start": 24, "end": 30}]}}, "schema": []}
{"input": "This investigation was undertaken to determine whether consuming several small feedings of preexercise carbohydrate (CHO), rather than a single bolus, would affect blood glucose and insulin responses during rest and exercise.", "output": {"entities": {"gene": [{"text": "insulin", "start": 182, "end": 189}]}}, "schema": []}
{"input": "The findings suggest that ERP effects of distinct memory processes are differentially influenced by the encoding instructions.", "output": {"entities": {}}, "schema": []}
{"input": "This coat protein consists of Sar1p, the Sec23p protein complex containing Sec23p and Sec24p, and the Sec13p protein complex containing Sec13p and a novel 150-kDa protein, p150.", "output": {"entities": {"gene": [{"text": "coat protein", "start": 5, "end": 17}, {"text": "Sar1p", "start": 30, "end": 35}, {"text": "Sec23p protein complex", "start": 41, "end": 63}, {"text": "Sec23p", "start": 75, "end": 81}, {"text": "Sec24p", "start": 86, "end": 92}, {"text": "Sec13p protein complex", "start": 102, "end": 124}, {"text": "Sec13p", "start": 136, "end": 142}, {"text": "150-kDa protein, p150", "start": 155, "end": 176}]}}, "schema": []}
{"input": "The second primary mutant contained a proline-to-leucine change at position 243 (P243L).", "output": {"entities": {}}, "schema": []}
{"input": "Induction of correctly spliced germline transcripts is necessary to target a switch region for recombination and switching.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, the PCE binds a Pbx dimer partner that behaves unlike Class I Hox proteins.", "output": {"entities": {"gene": [{"text": "PCE", "start": 10, "end": 13}, {"text": "Pbx dimer partner", "start": 22, "end": 39}, {"text": "Class I Hox proteins", "start": 60, "end": 80}]}}, "schema": []}
{"input": "Furthermore, the NH2-terminal portion of the homologue was not translocated into the outer membrane without its COOH-terminal part.", "output": {"entities": {}}, "schema": []}
{"input": "Molecular cloning and characterization of a cDNA, CHEMR1, encoding a chemokine receptor with a homology to the human C-C chemokine receptor, CCR-4.", "output": {"entities": {"gene": [{"text": "CHEMR1", "start": 50, "end": 56}, {"text": "human C-C chemokine receptor", "start": 111, "end": 139}, {"text": "CCR-4", "start": 141, "end": 146}]}}, "schema": []}
{"input": "Organization of the human LU gene and molecular basis of the Lu (a)/Lu (b) blood group polymorphism.", "output": {"entities": {"gene": [{"text": "human LU gene", "start": 20, "end": 33}, {"text": "Lu (a)", "start": 61, "end": 67}, {"text": "Lu (b)", "start": 68, "end": 74}]}}, "schema": []}
{"input": "Whereas the mutant enzymes terminate normally at the late terminator in T7 DNA (T (phi)) and rrnB T2, they fail to terminate at one of the termination sites of rrnB T1, and also fail to recognize the PTH and CJ signals.", "output": {"entities": {"gene": [{"text": "rrnB", "start": 93, "end": 97}, {"text": "rrnB", "start": 160, "end": 164}, {"text": "PTH", "start": 200, "end": 203}]}}, "schema": []}
{"input": "Cytological data suggest that the transgenes associate with a nucleolus.", "output": {"entities": {}}, "schema": []}
{"input": "Light regulatory unit 1 (LRU1) is necessary for and sufficient to mediate light-dependent activation of the chalcone synthase (CHS) minimal promoter in Petroselinum crispum.", "output": {"entities": {"gene": [{"text": "Light regulatory unit 1", "start": 0, "end": 23}, {"text": "LRU1", "start": 25, "end": 29}, {"text": "chalcone synthase (CHS) minimal promoter", "start": 108, "end": 148}]}}, "schema": []}
{"input": "The active state is terminated by hydrolysis of bound GTP, producing inactive ARF-GDP.", "output": {"entities": {"gene": [{"text": "ARF-GDP", "start": 78, "end": 85}]}}, "schema": []}
{"input": "We suggest that apart from the World Summit for Children' s under-five mortality target for the year 2000, intraregional targets to reduce geographical inequalities in under-five mortality should be specified.", "output": {"entities": {}}, "schema": []}
{"input": "The immunophilin, which can be of the FK506-or cyclosporin A-binding class, binds to hsp90 via its tetratricopeptide repeat (TPR) domain, and different receptor heterocomplexes exist depending upon which immunophilin occupies the TPR-binding region of hsp90.", "output": {"entities": {"gene": [{"text": "immunophilin", "start": 4, "end": 16}, {"text": "hsp90", "start": 85, "end": 90}, {"text": "immunophilin", "start": 204, "end": 216}, {"text": "hsp90", "start": 252, "end": 257}]}}, "schema": []}
{"input": "Sequencing of the facB gene revealed that it encodes a protein that contains an N-terminal GAL4-like Zn (II) 2Cys6 (or C6 zinc) binuclear cluster for DNA binding, leucine zipper-like heptad repeat motifs and central and C-terminal acidic alpha-helical regions, consistent with a function as a DNA-binding transcriptional activator.", "output": {"entities": {"gene": [{"text": "facB gene", "start": 18, "end": 27}, {"text": "GAL4", "start": 91, "end": 95}]}}, "schema": []}
{"input": "Overexpression of Sed5p allowed growth in the absence of Vti1p.", "output": {"entities": {"gene": [{"text": "Sed5p", "start": 18, "end": 23}, {"text": "Vti1p", "start": 57, "end": 62}]}}, "schema": []}
{"input": "The coding region of mkh1 is contained within a single exon encoding a 1, 116-amino-acid protein.", "output": {"entities": {"gene": [{"text": "mkh1", "start": 21, "end": 25}]}}, "schema": []}
{"input": "Strikingly, stoichiometric association of p107 or p130 with either cyclin E-cdk2 or cyclin A-cdk2 negated the activities of these kinases.", "output": {"entities": {"gene": [{"text": "p107", "start": 42, "end": 46}, {"text": "p130", "start": 50, "end": 54}, {"text": "cyclin E", "start": 67, "end": 75}, {"text": "cdk2", "start": 76, "end": 80}, {"text": "cyclin A", "start": 84, "end": 92}, {"text": "cdk2", "start": 93, "end": 97}]}}, "schema": []}
{"input": "Furthermore, p150 suppresses actin gelation, which is induced by smooth muscle alpha-actinin.", "output": {"entities": {"gene": [{"text": "p150", "start": 13, "end": 17}, {"text": "actin", "start": 29, "end": 34}, {"text": "smooth muscle alpha-actinin", "start": 65, "end": 92}]}}, "schema": []}
{"input": "Denaturation of the simian virus 40 origin of replication mediated by human replication protein A.", "output": {"entities": {"gene": [{"text": "human replication protein A", "start": 70, "end": 97}]}}, "schema": []}
{"input": "This effect was abolished once the EM motif in the promoter-reporter construct was mutated, thus suggesting that the synergistic transactivation function of the TEF-1-Max heterotypic complex is mediated through binding of the complex to the EM motif.", "output": {"entities": {"gene": [{"text": "TEF-1", "start": 161, "end": 166}, {"text": "Max", "start": 167, "end": 170}]}}, "schema": []}
{"input": "Interdigitated residues within a small region of VP16 interact with Oct-1, HCF, and DNA.", "output": {"entities": {"gene": [{"text": "VP16", "start": 49, "end": 53}, {"text": "Oct-1", "start": 68, "end": 73}, {"text": "HCF", "start": 75, "end": 78}]}}, "schema": []}
{"input": "With a view to identifying other important U14 interactions, a stem-loop domain required for activity of Saccharomyces cerevisiae U14 RNAs (the Y domain) was first subjected to detailed mutational analysis.", "output": {"entities": {"gene": [{"text": "U14", "start": 43, "end": 46}, {"text": "Saccharomyces cerevisiae U14 RNAs", "start": 105, "end": 138}]}}, "schema": []}
{"input": "Based on these results and because Cdc68 has been implicated as a regulator of chromatin structure, we postulate that polymerase alpha may interact with these proteins to gain access to its template or to origins of replication in vivo.", "output": {"entities": {"gene": [{"text": "Cdc68", "start": 35, "end": 40}, {"text": "polymerase alpha", "start": 118, "end": 134}]}}, "schema": []}
{"input": "Even when the inoculum size was reduced sixfold (i. e., 6 x 10 (6) CFU/mouse), 50% of the RB6-8C5-treated animals died within 6 days.", "output": {"entities": {"gene": [{"text": "RB6-8C5", "start": 90, "end": 97}]}}, "schema": []}
{"input": "In 12 cases (3. 1%), a change in stage resulted.", "output": {"entities": {}}, "schema": []}
{"input": "Promoter recognition algorithms identified divergent promoter elements within the CpG island, which lies between the ATM and E14/NPAT genes, and provide evidence for a putative second ATM promoter located within intron 3, immediately upstream of the first coding exon.", "output": {"entities": {"gene": [{"text": "ATM", "start": 117, "end": 120}, {"text": "E14", "start": 125, "end": 128}, {"text": "NPAT", "start": 129, "end": 133}, {"text": "ATM promoter", "start": 184, "end": 196}]}}, "schema": []}
{"input": "Recombinant soluble pMCP that lacked transmembrane and cytoplasmic domains had factor I cofactor activity in C3b cleavage, indicating that it is functionally, as well as structurally homologous to MCP.", "output": {"entities": {"gene": [{"text": "Recombinant soluble pMCP", "start": 0, "end": 24}, {"text": "factor I cofactor", "start": 79, "end": 96}, {"text": "C3b", "start": 109, "end": 112}, {"text": "MCP", "start": 197, "end": 200}]}}, "schema": []}
{"input": "Clinical and haematological signs are not specific in this setting, and the diagnosis relies on histological features, mainly bone marrow examination.", "output": {"entities": {}}, "schema": []}
{"input": "Spatial zones for muscle coactivation and the control of postural stability.", "output": {"entities": {}}, "schema": []}
{"input": "Liquid chromatographic separation was achieved on a Zorbax RX C8 analytical column using gradient elution.", "output": {"entities": {}}, "schema": []}
{"input": "The linear plasmid pDHL1 from Debaryomyces hansenii encodes a protein highly homologous to the pGKL1-plasmid DNA polymerase.", "output": {"entities": {"gene": [{"text": "pGKL1-plasmid DNA polymerase", "start": 95, "end": 123}]}}, "schema": []}
{"input": "The p20-CGGBP gene is conserved among mammals but shows no homology to non-vertebrate species.", "output": {"entities": {"gene": [{"text": "p20-CGGBP gene", "start": 4, "end": 18}]}}, "schema": []}
{"input": "The data suggest that like in yeast, in plants a certain subfamily of UBC is specifically involved in the proteolytic degradation of abnormal proteins as result of stress.", "output": {"entities": {"gene": [{"text": "UBC", "start": 70, "end": 73}]}}, "schema": []}
{"input": "The pWP-19 also encodes the AAV inverted terminal repeats for integration and replication and the herpes virus thymidine kinase promoter-driven gene for neomycin resistance (neoR).", "output": {"entities": {"gene": [{"text": "pWP-19", "start": 4, "end": 10}, {"text": "thymidine kinase", "start": 111, "end": 127}, {"text": "neoR", "start": 174, "end": 178}]}}, "schema": []}
{"input": "We have developed a rAAV-mediated gene transfer system for the rat preproinsulin II gene.", "output": {"entities": {"gene": [{"text": "rat preproinsulin II gene", "start": 63, "end": 88}]}}, "schema": []}
{"input": "A striking feature of the recombinant H19 allele is the occurrence of a parental imprint set on the neo replacement cassette.", "output": {"entities": {"gene": [{"text": "recombinant H19 allele", "start": 26, "end": 48}, {"text": "neo replacement cassette", "start": 100, "end": 124}]}}, "schema": []}
{"input": "This indicates that recruitment of large T antigen to the rRNA promoter by SL1 constitutes a crucial step in the activation process.", "output": {"entities": {"gene": [{"text": "large T antigen", "start": 35, "end": 50}, {"text": "SL1", "start": 75, "end": 78}]}}, "schema": []}
{"input": "In 1990, an International Commission for the Certification of Eradication of Poliomyelitis Eradication (ICCPE) was established by the Pan American Health Organization to eventually determine if transmission was interrupted.", "output": {"entities": {}}, "schema": []}
{"input": "Functional and regulatory analysis of the two copies of the fixNOQP operon of Rhizobium leguminosarum strain VF39.", "output": {"entities": {"gene": [{"text": "fixNOQP operon", "start": 60, "end": 74}]}}, "schema": []}
{"input": "This study describes a new MADS box gene, nmhC5, which along with nmh7 (J.", "output": {"entities": {"gene": [{"text": "MADS box gene", "start": 27, "end": 40}, {"text": "nmhC5", "start": 42, "end": 47}, {"text": "nmh7", "start": 66, "end": 70}]}}, "schema": []}
{"input": "Lung and multi-system damage were early indicators of poor outcome in severe non-fatal disease.", "output": {"entities": {}}, "schema": []}
{"input": "The results suggest that the bulbospinal micturition reflex evoked by bladder filling and L-dopa involves a descending pathway where transmission is partly mediated by spinal alpha 1-adrenoceptors.", "output": {"entities": {"gene": [{"text": "spinal alpha 1-adrenoceptors", "start": 168, "end": 196}]}}, "schema": []}
{"input": "Disturbance of regeneration in the above pathological condition results from the damage to tunica propria and loss of its function for the support of structural homeostasis.", "output": {"entities": {}}, "schema": []}
{"input": "Sternocleidomastoid, neck or facial muscles wasting were also found in three cases.", "output": {"entities": {}}, "schema": []}
{"input": "Identification of five new genes, closely related to the interleukin-1beta converting enzyme gene, that do not encode functional proteases.", "output": {"entities": {"gene": [{"text": "interleukin-1beta converting enzyme gene", "start": 57, "end": 97}]}}, "schema": []}
{"input": "The C-terminal mature region is highly conserved in other serine carboxypeptidases.", "output": {"entities": {"gene": [{"text": "serine carboxypeptidases", "start": 58, "end": 82}]}}, "schema": []}
{"input": "Here we demonstrate that AML1a, which solely has no effects as a transcriptional regulator, dominantly suppresses transcriptional activation by AML1b, and that AML1a exhibits the higher affinity for DNA-binding than AML1b.", "output": {"entities": {"gene": [{"text": "AML1a", "start": 25, "end": 30}, {"text": "AML1b", "start": 144, "end": 149}, {"text": "AML1a", "start": 160, "end": 165}, {"text": "AML1b", "start": 216, "end": 221}]}}, "schema": []}
{"input": "However, using ATL-16T nuclear extract, we demonstrated that GATA-4 is the only GATA-binding protein that forms specific DNA-protein complex with the-70 GATA site.", "output": {"entities": {"gene": [{"text": "GATA-4", "start": 61, "end": 67}, {"text": "GATA-binding protein", "start": 80, "end": 100}]}}, "schema": []}
{"input": "The impact of social support on the relationships of gay male couples is examined.", "output": {"entities": {}}, "schema": []}
{"input": "The ubiquitously expressed hypoxia-inducible factor-1 (HIF-1) is involved in expression of a large number of oxygen-regulated genes.", "output": {"entities": {"gene": [{"text": "hypoxia-inducible factor-1", "start": 27, "end": 53}, {"text": "HIF-1", "start": 55, "end": 60}]}}, "schema": []}
{"input": "Stromelysin-1, matrix metalloproteinase-3 (MMP-3), is an important endopeptidase selectively expressed by somatic cells in organ tissues.", "output": {"entities": {"gene": [{"text": "Stromelysin-1", "start": 0, "end": 13}, {"text": "matrix metalloproteinase-3", "start": 15, "end": 41}, {"text": "MMP-3", "start": 43, "end": 48}]}}, "schema": []}
{"input": "Tendon also shows a degree of extensibility.", "output": {"entities": {}}, "schema": []}
{"input": "Surveillance for preeclampsia was conducted by personnel unaware of treatment-group assignments, using standardized measurements of blood pressure and urinary protein excretion at uniformly scheduled prenatal visits, protocols for monitoring these measurements during the hospitalization for delivery, and reviews of medical records of unscheduled outpatient visits and all hospitalizations.", "output": {"entities": {}}, "schema": []}
{"input": "DNase I footprint analysis identified a protected region from-37 to-53.", "output": {"entities": {"gene": [{"text": "DNase I", "start": 0, "end": 7}]}}, "schema": []}
{"input": "We isolated several overlapping A-phage and cosmid clones that cover more than 100 kb of human DNA and contained the entire VDR gene.", "output": {"entities": {"gene": [{"text": "VDR gene", "start": 124, "end": 132}]}}, "schema": []}
{"input": "Here, we correlate Dox effects on cell cycle with changes of E2F/DP complexes and activity in differentiating C2C12 myocytes.", "output": {"entities": {"gene": [{"text": "E2F", "start": 61, "end": 64}, {"text": "DP", "start": 65, "end": 67}]}}, "schema": []}
{"input": "The products of the Saccharomyces cerevisiae CIN1, CIN2 and CIN4 genes participate in a nonessential pathway required for normal microtubule function.", "output": {"entities": {"gene": [{"text": "Saccharomyces cerevisiae CIN1", "start": 20, "end": 49}, {"text": "CIN2", "start": 51, "end": 55}, {"text": "CIN4 genes", "start": 60, "end": 70}]}}, "schema": []}
{"input": "Vitrectomy was still a significant risk factor when macular holes were excluded.", "output": {"entities": {}}, "schema": []}
{"input": "Invited editorial on \" Acute and chronic effects of exercise on leptin levels in humans \".", "output": {"entities": {"gene": [{"text": "leptin", "start": 64, "end": 70}]}}, "schema": []}
{"input": "Both promoters lack a TATA box, and Pint belongs to the MED-1 class of promoters, which initiate transcription at multiple sites.", "output": {"entities": {"gene": [{"text": "Pint", "start": 36, "end": 40}, {"text": "MED-1", "start": 56, "end": 61}]}}, "schema": []}
{"input": "Serum response factor (SRF), a member of an ancient family of DNA-binding proteins, is generally assumed to be a ubiquitous transcription factor involved in regulating growth factor-responsive genes.", "output": {"entities": {"gene": [{"text": "Serum response factor", "start": 0, "end": 21}, {"text": "SRF", "start": 23, "end": 26}]}}, "schema": []}
{"input": "We have initiated studies to identify candidate signal transducers that associate with the cytosolic domain (cd) of the IL-1R.", "output": {"entities": {"gene": [{"text": "IL-1R", "start": 120, "end": 125}]}}, "schema": []}
{"input": "In this study, we sought to identify mechanisms that could account for the antimitogenic effects of IL-4.", "output": {"entities": {"gene": [{"text": "IL-4", "start": 100, "end": 104}]}}, "schema": []}
{"input": "Pseudomonas aeruginosa strains infecting patients with cystic fibrosis (CF) acquire a mucoid phenotype due to overproduction of alginate.", "output": {"entities": {}}, "schema": []}
{"input": "Activity of palgD in the cysB mutant, in CHA and in the non-mucoid strain PAO was assessed by the use of a transcriptional algD-xylE fusion.", "output": {"entities": {"gene": [{"text": "palgD", "start": 12, "end": 17}, {"text": "cysB mutant", "start": 25, "end": 36}, {"text": "algD", "start": 123, "end": 127}, {"text": "xylE", "start": 128, "end": 132}]}}, "schema": []}
{"input": "The Man9-mannosidase specificity of the cDNA construct was verified by the observation that all peptide sequences derived from a previously purified, catalytically active 49-kDa fragment were found within the coding region.", "output": {"entities": {"gene": [{"text": "Man9-mannosidase", "start": 4, "end": 20}]}}, "schema": []}
{"input": "A soluble 62-kDa protein was produced without the proteolytic processing by inserting the coding sequence of amino acids 112 to 660 of ORF-2 in a baculovirus expression vector and using the corresponding virus to infect Sf9 cells.", "output": {"entities": {}}, "schema": []}
{"input": "The CPK-MB isoenzyme showed no percentage increase of total CPK higher than 5%, measured at 6, 12, and 24 h after the shock, independent of the number of attempts of cardioversion.", "output": {"entities": {"gene": [{"text": "CPK-MB", "start": 4, "end": 10}, {"text": "CPK", "start": 60, "end": 63}]}}, "schema": []}
{"input": "Serum and peritoneal dialysis fluid (PDF) were collected for assay throughout the course of the study and for 5 days thereafter.", "output": {"entities": {}}, "schema": []}
{"input": "Results support the hypothesis that endogenous corticotropin-releasing factor, perhaps acting at a peripheral binding site, suppresses the active behavioral response characteristic of pups during the early phase of isolation in novel surroundings.", "output": {"entities": {"gene": [{"text": "endogenous corticotropin-releasing factor", "start": 36, "end": 77}]}}, "schema": []}
{"input": "Liver regional blood volume (LRBV) is altered by several disease states and various drugs.", "output": {"entities": {}}, "schema": []}
{"input": "The gray matter NAA/mI ratio clearly separated the two groups.", "output": {"entities": {}}, "schema": []}
{"input": "As with the murine and human mb-1 genes, the 5' region of the bovine mb-1 gene lacked a TATA box.", "output": {"entities": {"gene": [{"text": "murine and human mb-1 genes", "start": 12, "end": 39}, {"text": "bovine mb-1 gene", "start": 62, "end": 78}]}}, "schema": []}
{"input": "Chloramphenicol acetyltransferase assays examining the ability of IE86 to repress activity from the HCMV major IE promoter or activate the HCMV early promoter for the 2. 2-kb class of RNAs demonstrated the functional integrity of the IE86 protein.", "output": {"entities": {"gene": [{"text": "Chloramphenicol acetyltransferase", "start": 0, "end": 33}, {"text": "IE86", "start": 66, "end": 70}, {"text": "IE promoter", "start": 111, "end": 122}, {"text": "HCMV early promoter", "start": 139, "end": 158}, {"text": "IE86 protein", "start": 234, "end": 246}]}}, "schema": []}
{"input": "ORF M1 has striking homology to poxvirus serpins, while ORF M11 encodes a potential homolog of Bcl-2-like molecules encoded by other gammaherpesviruses (gene 16 of HVS and KSHV and the BHRF1 gene of EBV).", "output": {"entities": {"gene": [{"text": "serpins", "start": 41, "end": 48}, {"text": "Bcl-2-like molecules", "start": 95, "end": 115}, {"text": "gene 16", "start": 153, "end": 160}, {"text": "BHRF1 gene", "start": 185, "end": 195}]}}, "schema": []}
{"input": "Transcription factor binding sites downstream of the human immunodeficiency virus type 1 transcription start site are important for virus infectivity.", "output": {"entities": {}}, "schema": []}
{"input": "Crystal structure of an oligomer of proteolytic zymogens: detailed conformational analysis of the bovine ternary complex and implications for their activation.", "output": {"entities": {}}, "schema": []}
{"input": "Through transient transfection of NIH3T3 fibroblast cells and gel mobility shift assays, the functional binding site was localized to a short region (-318 to-303 bp from the transcription start site) which has a CTCCC sequence.", "output": {"entities": {}}, "schema": []}
{"input": "We suppose that this injection speed (0. 1-0. 2 ml. s-1) is suitable for spinal anesthesia.", "output": {"entities": {}}, "schema": []}
{"input": "The current study demonstrates that T3-activated transcription of the NADPH: cytochrome P450 oxidoreductase (P450R) gene is dependent on the thyroid hormonal status of the animal, with both transcriptional and post-transcriptional pathways being important in regulating the cellular P450R mRNA level.", "output": {"entities": {"gene": [{"text": "NADPH: cytochrome P450 oxidoreductase", "start": 70, "end": 107}, {"text": "P450R", "start": 109, "end": 114}, {"text": "P450R", "start": 283, "end": 288}]}}, "schema": []}
{"input": "The behavior of different types of polytetrafluoroethylene (PTFE) prostheses in the reparative scarring process of abdominal wall defects.", "output": {"entities": {}}, "schema": []}
{"input": "The control group revealed significantly higher levels of coagulation factors II, V and VIII, compared to the index group.", "output": {"entities": {"gene": [{"text": "coagulation factors II, V and VIII", "start": 58, "end": 92}]}}, "schema": []}
{"input": "Stereotactic radiofrequency lesioning of the hamartoma resulted in seizure remission without complications 20 months after surgery.", "output": {"entities": {}}, "schema": []}
{"input": "If E. coli is present in any source water sample, the borehole and any directly connected borehole should be embargoed.", "output": {"entities": {}}, "schema": []}
{"input": "The following technique describes a modification to a bar superstructure that provided the advantages of convenience, security, and consistent positioning even though one implant was lost and the angulation of implants limited accuracy.", "output": {"entities": {}}, "schema": []}
{"input": "In summary, DDC express receptors for a broad panel of cytokines, even receptors for cytokines whose effects on DC are still unknown (i. e.", "output": {"entities": {}}, "schema": []}
{"input": "Its potential as a diagnostic tool for epidemiological surveillance was assessed in comparison with three other diagnostic tests: stool examination, ELISA with soluble egg antigen (SEA) and the circumoval precipitin test (COPT).", "output": {"entities": {"gene": [{"text": "soluble egg antigen", "start": 160, "end": 179}, {"text": "SEA", "start": 181, "end": 184}, {"text": "precipitin", "start": 205, "end": 215}]}}, "schema": []}
{"input": "These analyses demonstrate that the dUTPase isoforms are encoded by the same gene with isoform-specific transcripts arising through the use of alternative 5' exons.", "output": {"entities": {"gene": [{"text": "dUTPase", "start": 36, "end": 43}]}}, "schema": []}
{"input": "The selective 5-HT3 receptor antagonists ramosetron (YM060), YM114 (KAE-393), granisetron and ondansetron, and the substituted benzamides (5-HT4 receptor agonist/5-HT3 receptor antagonists) cisapride mosapride and SC-53116 dose-dependently enhanced gastric emptying in normal rats.", "output": {"entities": {"gene": [{"text": "5-HT3 receptor", "start": 14, "end": 28}, {"text": "5-HT4 receptor", "start": 139, "end": 153}, {"text": "5-HT3 receptor", "start": 162, "end": 176}]}}, "schema": []}
{"input": "Re-evaluation of the biopsy specimen from the right hip taken at the time of the initial operation showed areas of chondrosarcoma arising in the background of synovial chondromatosis.", "output": {"entities": {}}, "schema": []}
{"input": "All corneal buttons were processed for histopathologic and electron microscopic studies.", "output": {"entities": {}}, "schema": []}
{"input": "3600-fold to apparent homogeneity with a 41% yield by affinity chromatography utilizing DNA-cellulose; the purity of the final preparation was assessed by SDS/PAGE, lack of contamination by other nucleases and production of a monospecific antibody against the enzyme.", "output": {"entities": {}}, "schema": []}
{"input": "Human thymine-DNA glycosylase maps at chromosome 12q22-q24. 1: a region of high loss of heterozygosity in gastric cancer.", "output": {"entities": {"gene": [{"text": "Human thymine-DNA glycosylase", "start": 0, "end": 29}]}}, "schema": []}
{"input": "FOG is coexpressed with GATA-1 during embryonic development and in erythroid and megakaryocytic cells.", "output": {"entities": {"gene": [{"text": "FOG", "start": 0, "end": 3}, {"text": "GATA-1", "start": 24, "end": 30}]}}, "schema": []}
{"input": "We further found that KmMig1p is fully functional when expressed in S. cerevisiae.", "output": {"entities": {"gene": [{"text": "KmMig1p", "start": 22, "end": 29}]}}, "schema": []}
{"input": "Autoimmune neutropenia (AIN) is a frequent cause of chronic neutropenia especially in youngest children.", "output": {"entities": {}}, "schema": []}
{"input": "With regard to the characteristic expression pattern of DJ protein and its conspicuous repeat units possible functional roles are discussed.", "output": {"entities": {"gene": [{"text": "DJ protein", "start": 56, "end": 66}]}}, "schema": []}
{"input": "Future analysis of long-term outcome measures of performance with the implant will confirm or dispute the benefit of ear selection using the Prom-EABR.", "output": {"entities": {}}, "schema": []}
{"input": "This protein, designated p532 based on its predicted molecular weight (EMBO J 15: 5738, 1996), contains multiple structural domains including two regions of seven internal repeats highly related to the cell cycle regulator RCC1, a guanine nucleotide exchange factor for the small GTP-binding protein Ran, seven beta-repeat domains characteristic of the beta subunit of heterotrimeric G proteins, three putative SH3 binding sites, a putative leucine-zipper and a carboxy-terminal HECT domain characteristic of E3 ubiquitin-protein ligases.", "output": {"entities": {"gene": [{"text": "p532", "start": 25, "end": 29}, {"text": "RCC1", "start": 223, "end": 227}, {"text": "guanine nucleotide exchange factor", "start": 231, "end": 265}, {"text": "small GTP-binding protein Ran", "start": 274, "end": 303}, {"text": "heterotrimeric G proteins", "start": 369, "end": 394}, {"text": "SH3 binding sites", "start": 411, "end": 428}, {"text": "carboxy-terminal HECT domain", "start": 462, "end": 490}, {"text": "E3 ubiquitin-protein ligases", "start": 509, "end": 537}]}}, "schema": []}
{"input": "Thus, the L45 sequence between kinase subdomains IV and V specifies TGF-beta responsiveness of the type I receptor.", "output": {"entities": {"gene": [{"text": "TGF-beta", "start": 68, "end": 76}, {"text": "type I receptor", "start": 99, "end": 114}]}}, "schema": []}
{"input": "The two mouse lines carrying the unfragmented Hnf3g-lacZ YAC showed tissue-specific, copy number-dependent and position-independent expression, proving that 170 kb of the Hnf3g locus contain all elements important in the regulation of Hnf3g.", "output": {"entities": {"gene": [{"text": "Hnf3g", "start": 46, "end": 51}, {"text": "lacZ", "start": 52, "end": 56}, {"text": "Hnf3g", "start": 171, "end": 176}, {"text": "Hnf3g", "start": 235, "end": 240}]}}, "schema": []}
{"input": "Second, plasmid-derived transgenes and gene targeting of the endogenous Hnf3g gene locus were used to demonstrate that the 3'-flanking region of the gene is necessary and sufficient to direct reporter gene expression in liver, pancreas, stomach and small intestine.", "output": {"entities": {"gene": [{"text": "endogenous Hnf3g gene locus", "start": 61, "end": 88}]}}, "schema": []}
{"input": "Here we have tested the hypothesis that the short transcripts, or proteins translated from the short transcripts, are also required for respiration.", "output": {"entities": {}}, "schema": []}
{"input": "Upstream activating sequences (UASs) derived from known Ste12p-dependent genes have previously been characterized to require either multiple PREs or a single PRE coupled to a binding site for a second protein.", "output": {"entities": {"gene": [{"text": "Ste12p", "start": 56, "end": 62}]}}, "schema": []}
{"input": "Prominent protein kinase cascades are those that activate mitogen-activated protein (MAP) kinases.", "output": {"entities": {"gene": [{"text": "mitogen-activated protein (MAP) kinases", "start": 58, "end": 97}]}}, "schema": []}
{"input": "JNK is additionally regulated by the Ras-related G proteins Rac and Cdc42.", "output": {"entities": {"gene": [{"text": "JNK", "start": 0, "end": 3}, {"text": "Ras", "start": 37, "end": 40}, {"text": "G proteins Rac", "start": 49, "end": 63}, {"text": "Cdc42", "start": 68, "end": 73}]}}, "schema": []}
{"input": "In this study, we tested this notion by using ligation-mediated PCR to assess the formation of recombination-activating gene (RAG)-dependent double-strand breaks (DSBs) at RSSs 3' of Ddelta3 and 5' of Jdelta1.", "output": {"entities": {"gene": [{"text": "recombination-activating gene", "start": 95, "end": 124}, {"text": "RAG", "start": 126, "end": 129}, {"text": "Ddelta3", "start": 183, "end": 190}, {"text": "Jdelta1", "start": 201, "end": 208}]}}, "schema": []}
{"input": "Recent studies have demonstrated that Cbl, the 120-kDa protein product of the c-cbl proto-oncogene, serves as a substrate of a number of receptor-coupled tyrosine kinases and forms complexes with SH3 and SH2 domain-containing proteins, pointing to its role in signal transduction.", "output": {"entities": {"gene": [{"text": "Cbl", "start": 38, "end": 41}, {"text": "c-cbl proto-oncogene", "start": 78, "end": 98}, {"text": "receptor-coupled tyrosine kinases", "start": 137, "end": 170}, {"text": "SH3", "start": 196, "end": 199}, {"text": "SH2", "start": 204, "end": 207}]}}, "schema": []}
{"input": "Although neither constitutively activated MEK (MEK-2E) nor v-Src was sufficient individually to differentiate the H19-7 cells, coexpression of constitutively activated MEK and v-Src induced neurite outgrowth.", "output": {"entities": {"gene": [{"text": "MEK", "start": 42, "end": 45}, {"text": "MEK-2E", "start": 47, "end": 53}, {"text": "v-Src", "start": 59, "end": 64}, {"text": "MEK", "start": 168, "end": 171}, {"text": "v-Src", "start": 176, "end": 181}]}}, "schema": []}
{"input": "This mechanism is in contrast to other cases of splicing regulation by PTB, in which the protein represses the splice site to which it binds.", "output": {"entities": {"gene": [{"text": "PTB", "start": 71, "end": 74}]}}, "schema": []}
{"input": "While important for ligand-dependent transactivation, this interaction surface is not directly involved in transrepression of AP-1 activity.", "output": {"entities": {"gene": [{"text": "AP-1", "start": 126, "end": 130}]}}, "schema": []}
{"input": "Gal4-Eed fusion protein represses transcription of a reporter gene driven by a promoter that contains Gal4-binding DNA elements.", "output": {"entities": {"gene": [{"text": "Gal4", "start": 0, "end": 4}, {"text": "Eed", "start": 5, "end": 8}, {"text": "Gal4-binding DNA elements", "start": 102, "end": 127}]}}, "schema": []}
{"input": "In situ hybridization analysis in adult rat tissue reveals good correlation with this pattern and indicates that drm mRNA is most highly expressed in nondividing and terminally differentiated cells, such as neurons, type 1 lung cells, and goblet cells.", "output": {"entities": {"gene": [{"text": "drm mRNA", "start": 113, "end": 121}]}}, "schema": []}
{"input": "A 2 years and 9 months old female patient, with the diagnosis of Weaver syndrome is reported.", "output": {"entities": {}}, "schema": []}
{"input": "Confirming measures made by nurses and additionally, ABPM for women, seem to lessen this effect.", "output": {"entities": {}}, "schema": []}
{"input": "In a series of patients with neuroinfection, Lyme disease, Guillain Barre syndrome, demyelinization, partial or generalized, epilepsy, we have investigated antiphospholipid antibodies of IgG and IgM subtypes, together with anticoagulant factors, member of thrombocytes, sedimentation rate of erythrocytes.", "output": {"entities": {"gene": [{"text": "IgG", "start": 187, "end": 190}, {"text": "IgM", "start": 195, "end": 198}]}}, "schema": []}
{"input": "Second, the membrane expression of alpha and beta subunits was mimicked by cholesterol and 17-ketocholesterol, both of which inhibit HMG-CoA reductase.", "output": {"entities": {"gene": [{"text": "HMG-CoA reductase", "start": 133, "end": 150}]}}, "schema": []}
{"input": "Our results suggest that Lrp binds a central palindromic site, interacting predominantly with the major groove of its DNA target, and that additional dimers bind to flanking sites to form a nucleoprotein activation complex.", "output": {"entities": {"gene": [{"text": "Lrp", "start": 25, "end": 28}]}}, "schema": []}
{"input": "Sustained activation of p21 expression is proposed to be a distinguishing feature of the activity of NGF that contributes to PC12 growth arrest during differentiation", "output": {"entities": {"gene": [{"text": "p21", "start": 24, "end": 27}, {"text": "NGF", "start": 101, "end": 104}]}}, "schema": []}
{"input": "The remaining 80 patients underwent recordings of ECG, beat-to-beat arterial oxygen saturation (SaO2), and respiration during both spontaneous and controlled breathing.", "output": {"entities": {}}, "schema": []}
{"input": "The mean total white cell count increased from a baseline of 11. 3 x 10 (9)/L (SD 2. 3) to 16. 2 x 10 (9)/L (SD 4. 6) on day 1, normalising thereafter.", "output": {"entities": {}}, "schema": []}
{"input": "In all experimental eyes, there was a marked reduction, but never a complete absence of adrenergic nerves in the iris.", "output": {"entities": {}}, "schema": []}
{"input": "These lesions may be treated by propranolol or phentolamine.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, ICER negatively autoregulates the alternative promoter, thus generating a feedback loop.", "output": {"entities": {"gene": [{"text": "ICER", "start": 13, "end": 17}]}}, "schema": []}
{"input": "This night-day oscillation is driven by the endogenous clock (located in the suprachiasmatic nucleus, SCN).", "output": {"entities": {}}, "schema": []}
{"input": "The Ogg1 protein efficiently cleaves a DNA duplex where a preformed AP site is placed opposite a cytosine (AP/C).", "output": {"entities": {"gene": [{"text": "Ogg1 protein", "start": 4, "end": 16}, {"text": "AP site", "start": 68, "end": 75}]}}, "schema": []}
{"input": "A consensus sequence indicates a highly conserved lysine residue, K120 of endonuclease III or K241 of Ogg1, respectively.", "output": {"entities": {"gene": [{"text": "endonuclease III", "start": 74, "end": 90}, {"text": "Ogg1", "start": 102, "end": 106}]}}, "schema": []}
{"input": "Overall, these findings demonstrate that mutations E768D and V804L are gain-of-function mutations that confer to the long RET isoform the capacity to exert a biological effect, although these mutations are more weakly activating than the MEN2A and MEN2B mutations.", "output": {"entities": {"gene": [{"text": "long RET isoform", "start": 117, "end": 133}, {"text": "MEN2A", "start": 238, "end": 243}, {"text": "MEN2B", "start": 248, "end": 253}]}}, "schema": []}
{"input": "Volunteers were irradiated on their backs with suberythemal UV daily for 5 d after application of the sunscreens and their base lotion to different sites.", "output": {"entities": {}}, "schema": []}
{"input": "E2F is a heterodimeric complex consisting of E2F family members (1-5) and DP proteins (1-3).", "output": {"entities": {"gene": [{"text": "E2F", "start": 0, "end": 3}, {"text": "E2F family members (1-5)", "start": 45, "end": 69}, {"text": "DP proteins (1-3)", "start": 74, "end": 91}]}}, "schema": []}
{"input": "EBER1 mRNA, a consistent marker of viral latency, was positive in all PEL cases, although at lower levels than in the non-PEL controls due to EBER1 expression by only a variable subset of lymphoma cells.", "output": {"entities": {"gene": [{"text": "EBER1 mRNA", "start": 0, "end": 10}, {"text": "EBER1", "start": 142, "end": 147}]}}, "schema": []}
{"input": "METHODS: Four hundred fifty patients with the diagnosis of squamous cell carcinoma of the oral cavity received their primary treatment at Roswell Park Cancer Center (RPCI) from 1971 to 1991.", "output": {"entities": {}}, "schema": []}
{"input": "Therefore, use of presaturation is recommended for myocardial motion studies using cine PC velocity data.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, the DNA-binding experiments show that either one of the two MADS domains of a dimer can be sufficient to confer a particular DNA-binding specificity to the complex and that sequences outside the amino-terminal basic region of the MADS domain can, in some cases, contribute to the DNA-binding specificity of the proteins.", "output": {"entities": {"gene": [{"text": "MADS domains", "start": 73, "end": 85}, {"text": "MADS", "start": 243, "end": 247}]}}, "schema": []}
{"input": "PURPOSE/OBJECTIVES: To examine the question of whether an early first full-term pregnancy (FFTP) protects against breast cancer and whether interruption of the pregnancy with an induced abortion increases breast cancer risk.", "output": {"entities": {}}, "schema": []}
{"input": "Two related studies conducted over a five week period measured and typed HLA-DQA1 from accumulated DNA on autopsy room and Forensic DNA Laboratory structures.", "output": {"entities": {"gene": [{"text": "HLA-DQA1", "start": 73, "end": 81}]}}, "schema": []}
{"input": "Thirty-two rats were divided into four groups.", "output": {"entities": {}}, "schema": []}
{"input": "Mutagenesis of the pecT regulatory region revealed the presence of two sites in which insertions reproduced the pec-1 phenotype.", "output": {"entities": {"gene": [{"text": "pecT", "start": 19, "end": 23}, {"text": "pec-1", "start": 112, "end": 117}]}}, "schema": []}
{"input": "BRCA1, a familial breast and ovarian cancer susceptibility gene encodes nuclear phosphoproteins that function as tumor suppressors in human breast cancer cells.", "output": {"entities": {"gene": [{"text": "BRCA1", "start": 0, "end": 5}]}}, "schema": []}
{"input": "The alternative splice sites for the smallest adducin isoform, beta-3, are alternative donor and acceptor sites within exons 7 and 12.", "output": {"entities": {"gene": [{"text": "adducin", "start": 46, "end": 53}, {"text": "beta-3", "start": 63, "end": 69}]}}, "schema": []}
{"input": "Two new temperature-sensitive alleles of SEC3, 1 of 10 late-acting SEC genes required for targeting or fusion of post-Golgi secretory vesicles to the plasma membrane in Saccharomyces cerevisiae, were isolated in a screen for temperature-sensitive secretory mutants that are synthetically lethal with sec4-8.", "output": {"entities": {"gene": [{"text": "SEC3", "start": 41, "end": 45}, {"text": "SEC genes", "start": 67, "end": 76}, {"text": "sec4-8", "start": 300, "end": 306}]}}, "schema": []}
{"input": "Cell 49, 753-761].", "output": {"entities": {}}, "schema": []}
{"input": "Twenty-one ELISA-positive sera were tested and confirmed positive by plaque reduction neutralization testing.", "output": {"entities": {}}, "schema": []}
{"input": "Patients received either diltiazem CD 180 mg or placebo once/day in combination with existing antianginal therapy.", "output": {"entities": {}}, "schema": []}
{"input": "Reactive lymphoid hyperplasia was found in 15 cases, 2 cases had angiofollicular lymphoid hyperplasia or Castleman' s disease, atypical lymphoid hyperplasia suggestive of malignant lymphoma was observed in 3 cases, and malignant lymphoma was diagnosed in the remaining 4 cases.", "output": {"entities": {}}, "schema": []}
{"input": "Tyrosine 1356 forms a multisubstrate binding site for the Grb2 and Shc adaptor proteins, the p85 subunit of phosphatidylinositol 3'-kinase, phospholipase Cgamma, and a phosphatase, SHP2.", "output": {"entities": {"gene": [{"text": "Grb2", "start": 58, "end": 62}, {"text": "Shc adaptor proteins", "start": 67, "end": 87}, {"text": "p85 subunit", "start": 93, "end": 104}, {"text": "phosphatidylinositol 3'-kinase", "start": 108, "end": 138}, {"text": "phospholipase Cgamma", "start": 140, "end": 160}, {"text": "SHP2", "start": 181, "end": 185}]}}, "schema": []}
{"input": "Then we correlated HRCT findings with the clinical features, pulmonary functions and methacholine PC20 (PC20M) and studied their clinical significance.", "output": {"entities": {}}, "schema": []}
{"input": "Gtx mRNA accumulates in parallel with the RNAs encoding the major structural proteins of myelin, myelin basic protein (MBP), and proteolipid protein (PLP) during postnatal brain development; Gtx mRNA decreases in parallel with MBP and PLP mRNAs in the brains of myelin-deficient rats, which have a point mutation in the PLP gene.", "output": {"entities": {"gene": [{"text": "Gtx mRNA", "start": 0, "end": 8}, {"text": "myelin basic protein", "start": 97, "end": 117}, {"text": "MBP", "start": 119, "end": 122}, {"text": "proteolipid protein", "start": 129, "end": 148}, {"text": "PLP", "start": 150, "end": 153}, {"text": "Gtx mRNA", "start": 191, "end": 199}, {"text": "MBP", "start": 227, "end": 230}, {"text": "PLP mRNAs", "start": 235, "end": 244}, {"text": "PLP gene", "start": 320, "end": 328}]}}, "schema": []}
{"input": "Contacts between Bacillus subtilis catabolite regulatory protein CcpA and amyO target site.", "output": {"entities": {"gene": [{"text": "CcpA", "start": 65, "end": 69}, {"text": "amyO", "start": 74, "end": 78}]}}, "schema": []}
{"input": "They also interact with GTPase activating proteins encoded by IRA1 and IRA2.", "output": {"entities": {"gene": [{"text": "GTPase activating proteins", "start": 24, "end": 50}, {"text": "IRA1", "start": 62, "end": 66}, {"text": "IRA2", "start": 71, "end": 75}]}}, "schema": []}
{"input": "For E2, each cat was given either 5 (group [G] 1) or 10 (G2) mg of itraconazole/kg (capsules) twice daily for 6 weeks.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: For E1, itraconazole plasma drug concentration extrapolated to time zero (IV dose) was 5. 2 +/-1. 4 micrograms/ml, and mean residence time (MRT) was 37 +/-16 hours.", "output": {"entities": {}}, "schema": []}
{"input": "The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p.", "output": {"entities": {"gene": [{"text": "U4", "start": 10, "end": 12}, {"text": "U6", "start": 13, "end": 15}, {"text": "Prp4p", "start": 115, "end": 120}, {"text": "Prp3p", "start": 125, "end": 130}]}}, "schema": []}
{"input": "G-CSF was started on day 3 of each cycle (5 microg/kg/day) and was stopped the day before the last apheresis or when absolute neutrophil count was above 0. 5 x 10 (9)/l.", "output": {"entities": {"gene": [{"text": "G-CSF", "start": 0, "end": 5}]}}, "schema": []}
{"input": "Supershift assays, using Jun and Fos family member-specific antibodies, showed that protein complexes formed by AtT-20 cell nuclear extracts bound to the c-jun AP-1 site were comprised of Jun family members, JunD, JunB, and cJun.", "output": {"entities": {"gene": [{"text": "Jun and Fos family member-specific antibodies", "start": 25, "end": 70}, {"text": "c-jun AP-1 site", "start": 154, "end": 169}, {"text": "Jun", "start": 188, "end": 191}, {"text": "JunD", "start": 208, "end": 212}, {"text": "JunB", "start": 214, "end": 218}, {"text": "cJun", "start": 224, "end": 228}]}}, "schema": []}
{"input": "The majority of PI kinase activity appeared to be cbl-associated after PRL stimulation.", "output": {"entities": {"gene": [{"text": "PI kinase", "start": 16, "end": 25}, {"text": "cbl", "start": 50, "end": 53}, {"text": "PRL", "start": 71, "end": 74}]}}, "schema": []}
{"input": "Mutation of Enh4, an essential GT-IIC-like enhanson in the context of the intact enhancer, abolishes silencer activity, and multimerized GT-IIC enhansons mimic the intact CSEn enhancer/silencer activities in BeWo and GC cells, respectively.", "output": {"entities": {"gene": [{"text": "Enh4", "start": 12, "end": 16}, {"text": "GT-IIC-like enhanson", "start": 31, "end": 51}, {"text": "GT-IIC enhansons", "start": 137, "end": 153}, {"text": "CSEn enhancer/silencer", "start": 171, "end": 193}]}}, "schema": []}
{"input": "Using lectin-affinity chromatography, discordance between the pattern of O-glycosylation of SSBP and DSBP was demonstrated.", "output": {"entities": {"gene": [{"text": "lectin", "start": 6, "end": 12}, {"text": "SSBP", "start": 92, "end": 96}, {"text": "DSBP", "start": 101, "end": 105}]}}, "schema": []}
{"input": "Deletion mapping experiments determined that the sequences required for full activity in MSC-1 cells were included within 619 bp of the start site and identified several regions that demonstrated increased luciferase activity: the-583 bp to-564 bp,-503 bp to-484 bp, and-114 bp to-65 regions.", "output": {"entities": {"gene": [{"text": "luciferase", "start": 206, "end": 216}]}}, "schema": []}
{"input": "Furthermore, the PH and PTB domains are highly homologous (at least 40% identical) to those found in insulin receptor substrates 1, 2, and 3 (IRS-1, IRS-2, and IRS-3).", "output": {"entities": {"gene": [{"text": "PH", "start": 17, "end": 19}, {"text": "insulin receptor substrates 1, 2, and 3", "start": 101, "end": 140}, {"text": "IRS-1", "start": 142, "end": 147}, {"text": "IRS-2", "start": 149, "end": 154}, {"text": "IRS-3", "start": 160, "end": 165}]}}, "schema": []}
{"input": "The mouse extracellular signal-regulated kinase 2 gene.", "output": {"entities": {"gene": [{"text": "extracellular signal-regulated kinase 2 gene", "start": 10, "end": 54}]}}, "schema": []}
{"input": "As demonstrated by gel mobility shift analysis and supershift experiments, FIRE1, located between-516 and-498, is responsible for binding NF-Y.", "output": {"entities": {"gene": [{"text": "FIRE1", "start": 75, "end": 80}, {"text": "NF-Y", "start": 138, "end": 142}]}}, "schema": []}
{"input": "MR imaging of traumatic head injuries using FLAIR technique", "output": {"entities": {}}, "schema": []}
{"input": "Gag protein sequence motifs of the NC domain of primate foamy viruses assumed to be involved in genome encapsidation are not conserved in FeFV.", "output": {"entities": {"gene": [{"text": "Gag", "start": 0, "end": 3}, {"text": "NC domain", "start": 35, "end": 44}]}}, "schema": []}
{"input": "Induction of B cell apoptosis by co-cross-linking CD23 and sIg involves aberrant regulation of c-myc and is inhibited by bcl-2.", "output": {"entities": {"gene": [{"text": "CD23", "start": 50, "end": 54}, {"text": "sIg", "start": 59, "end": 62}, {"text": "c-myc", "start": 95, "end": 100}, {"text": "bcl-2", "start": 121, "end": 126}]}}, "schema": []}
{"input": "Here, we report theoretical models for the Gla and EGF-1 modules of human PS constructed using prothrombin and factor X experimental structures.", "output": {"entities": {"gene": [{"text": "EGF-1 modules", "start": 51, "end": 64}, {"text": "human PS", "start": 68, "end": 76}, {"text": "prothrombin", "start": 95, "end": 106}, {"text": "factor X", "start": 111, "end": 119}]}}, "schema": []}
{"input": "The Cut9 subunit is likely to be a target for regulating APC/cyclosome function through protein-protein interactions and phosphorylation.", "output": {"entities": {"gene": [{"text": "Cut9 subunit", "start": 4, "end": 16}, {"text": "APC/cyclosome", "start": 57, "end": 70}]}}, "schema": []}
{"input": "The dose was 50 Gy/20 fractions/5 weeks.", "output": {"entities": {}}, "schema": []}
{"input": "All the women received 13. 5 mg plain bupivacaine via subarachnoid injection at the L2-3 interspace.", "output": {"entities": {}}, "schema": []}
{"input": "Far from this being the case, however, the measurement of apo B has met every reasonable standard of laboratory precision and reliability to allow its widespread introduction in clinical laboratories.", "output": {"entities": {"gene": [{"text": "apo B", "start": 58, "end": 63}]}}, "schema": []}
{"input": "Two soybean cDNA clones, SPK-3 and SPK-4, encoding putative protein kinases were isolated and characterized.", "output": {"entities": {"gene": [{"text": "SPK-3", "start": 25, "end": 30}, {"text": "SPK-4", "start": 35, "end": 40}]}}, "schema": []}
{"input": "Genes belonging to the ras superfamily encode low-molecular-weight GTP/GDP-binding proteins that are highly conserved in wide variety of organisms.", "output": {"entities": {"gene": [{"text": "ras superfamily", "start": 23, "end": 38}, {"text": "low-molecular-weight GTP/GDP-binding proteins", "start": 46, "end": 91}]}}, "schema": []}
{"input": "Ent-kaurene synthase from the fungus Phaeosphaeria sp.", "output": {"entities": {"gene": [{"text": "Ent-kaurene synthase from the fungus Phaeosphaeria", "start": 0, "end": 50}]}}, "schema": []}
{"input": "In this report, we identify and characterize two overlapping ELL functional domains that govern its interaction with RNA polymerase II and the ternary elongation complex.", "output": {"entities": {"gene": [{"text": "ELL functional domains", "start": 61, "end": 83}, {"text": "RNA polymerase II", "start": 117, "end": 134}]}}, "schema": []}
{"input": "Eight induced cDNA sequences were identified and designated message up-regulated during death (mud)-1-8.", "output": {"entities": {"gene": [{"text": "message up-regulated during death (mud)-1-8", "start": 60, "end": 103}]}}, "schema": []}
{"input": "The position, transcription orientation, and imprinted status of the genes immediately flanking Igf2r have been assessed.", "output": {"entities": {"gene": [{"text": "Igf2r", "start": 96, "end": 101}]}}, "schema": []}
{"input": "Here, we describe directional chromosome walking studies starting from D8S260 as well as D8S285.", "output": {"entities": {"gene": [{"text": "D8S260", "start": 71, "end": 77}, {"text": "D8S285", "start": 89, "end": 95}]}}, "schema": []}
{"input": "We describe a novel zinc finger protein, dsRBP-ZFa, isolated by screening an expression library with dsRNA.", "output": {"entities": {"gene": [{"text": "zinc finger protein", "start": 20, "end": 39}, {"text": "dsRBP-ZFa", "start": 41, "end": 50}]}}, "schema": []}
{"input": "Our results indicate that the retroplasmid reverse transcriptase is uniquely adapted to initiate cDNA synthesis by recognizing a 3' CCA sequence.", "output": {"entities": {"gene": [{"text": "reverse transcriptase", "start": 43, "end": 64}]}}, "schema": []}
{"input": "Nasal absorption was rapid, nasal bioavailability was 43%, and the iv and nasal elimination profiles were similar.", "output": {"entities": {}}, "schema": []}
{"input": "Together, these results suggest that EGF/Ras/Raf induces transcription via combined activation of ATF3/c-Jun and a 52-kDa nuclear factor, whereas JunD acts as a repressor of this response.", "output": {"entities": {"gene": [{"text": "EGF", "start": 37, "end": 40}, {"text": "Ras", "start": 41, "end": 44}, {"text": "Raf", "start": 45, "end": 48}, {"text": "ATF3", "start": 98, "end": 102}, {"text": "c-Jun", "start": 103, "end": 108}, {"text": "JunD", "start": 146, "end": 150}]}}, "schema": []}
{"input": "Together, these data support a model in which Tax anchors CBP to the HTLV-1 promoter, with strong transcriptional activation resulting from the CBP-associated activities of nucleosome remodeling and recruitment of the general transcription machinery.", "output": {"entities": {"gene": [{"text": "Tax", "start": 46, "end": 49}, {"text": "CBP", "start": 58, "end": 61}, {"text": "HTLV-1 promoter", "start": 69, "end": 84}, {"text": "CBP", "start": 144, "end": 147}]}}, "schema": []}
{"input": "DNase I and 1, 10-phenanthroline-copper footprinting of MURA-Mu1 TIR complexes indicate that MURA binds to a conserved approximately 32-bp region in the TIR of Mu1.", "output": {"entities": {"gene": [{"text": "DNase I", "start": 0, "end": 7}, {"text": "MURA", "start": 56, "end": 60}, {"text": "Mu1", "start": 61, "end": 64}, {"text": "MURA", "start": 93, "end": 97}, {"text": "Mu1", "start": 160, "end": 163}]}}, "schema": []}
{"input": "Various assays demonstrate promoter activity in this sequence that reproduces the normal control of E2F2 expression during a growth stimulation.", "output": {"entities": {"gene": [{"text": "E2F2", "start": 100, "end": 104}]}}, "schema": []}
{"input": "In the adult mouse, ERR alpha is most highly expressed in kidney, heart, and brown adipocytes, tissues which preferentially metabolize fatty acids.", "output": {"entities": {"gene": [{"text": "ERR alpha", "start": 20, "end": 29}]}}, "schema": []}
{"input": "The MCAD nuclear receptor response element 1 (NRRE-1) interacts in vitro with ERR alpha expressed in COS-7 cells.", "output": {"entities": {"gene": [{"text": "MCAD nuclear receptor response element 1", "start": 4, "end": 44}, {"text": "NRRE-1", "start": 46, "end": 52}, {"text": "ERR alpha", "start": 78, "end": 87}]}}, "schema": []}
{"input": "Mapping features of HIV-1 integrase near selected sites on viral and target DNA molecules in an active enzyme-DNA complex by photo-cross-linking.", "output": {"entities": {"gene": [{"text": "HIV-1 integrase", "start": 20, "end": 35}]}}, "schema": []}
{"input": "The complete response (CR) rate was 34% in the CODE with rhG-CSF group and 23% in the CODE alone group; the median survival was 59 and 32 weeks, respectively, in these groups (P = 0. 004).", "output": {"entities": {"gene": [{"text": "rhG-CSF", "start": 57, "end": 64}]}}, "schema": []}
{"input": "Heterogeneous nuclear ribonucleoprotein A1 binds to the transcription-regulatory region of mouse hepatitis virus RNA.", "output": {"entities": {"gene": [{"text": "Heterogeneous nuclear ribonucleoprotein A1", "start": 0, "end": 42}]}}, "schema": []}
{"input": "In the first part of our study, the highest mutagenicity was revealed by TA98 strain without enzymatic activation, suggesting a direct-acting mutagenicity prevalence in diesel particulate.", "output": {"entities": {}}, "schema": []}
{"input": "The addition of culture to the CC and CC: SW by-products resulted in pH values lower (P < 0. 05) than those without culture on Day 21, and the 15% carbohydrate treatment significantly reduced pH beyond the 5% carbohydrate.", "output": {"entities": {}}, "schema": []}
{"input": "Myocardial interstitial edema is more likely a potential mechanism of diastolic dysfunction after DC shocks.", "output": {"entities": {}}, "schema": []}
{"input": "Two experiments (N = 20 each) were carried out to explore the nature of ERP negativities in a visuospatial memory task and in an auditory spatial memory task, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Biol.", "output": {"entities": {}}, "schema": []}
{"input": "The pattern and timing of CARP mRNA expression, including transient expression in the tongue at 14. 5 days p. c., coincides with that of Nkx2. 5/Csx (a putative homolog of tinman, the Drosophila melanogaster gene responsible for cardiac development).", "output": {"entities": {"gene": [{"text": "CARP mRNA", "start": 26, "end": 35}, {"text": "Nkx2. 5", "start": 137, "end": 144}, {"text": "Csx", "start": 145, "end": 148}, {"text": "tinman", "start": 172, "end": 178}]}}, "schema": []}
{"input": "Overexpression of CARP in cardiomyocytes suppresses cardiac troponin C and atrial natriuretic factor transcription.", "output": {"entities": {"gene": [{"text": "CARP", "start": 18, "end": 22}, {"text": "cardiac troponin C", "start": 52, "end": 70}, {"text": "atrial natriuretic factor", "start": 75, "end": 100}]}}, "schema": []}
{"input": "Substrate specificity of the RNase activity of yeast RNA polymerase III.", "output": {"entities": {"gene": [{"text": "RNase", "start": 29, "end": 34}, {"text": "yeast RNA polymerase III", "start": 47, "end": 71}]}}, "schema": []}
{"input": "Electrophoretic mobility shift assays and competition experiments showed that site A is recognized by an NF1 protein.", "output": {"entities": {"gene": [{"text": "NF1 protein", "start": 105, "end": 116}]}}, "schema": []}
{"input": "Examination of the MMP-2 RE1 sequence revealed an incomplete Y-box sequence (CTGCTGGGCAAG), which specifically interacted with recombinant YB-1 on DMS protection footprinting analysis.", "output": {"entities": {"gene": [{"text": "MMP-2 RE1 sequence", "start": 19, "end": 37}, {"text": "recombinant YB-1", "start": 127, "end": 143}]}}, "schema": []}
{"input": "Hence, scs32 only partially suppressed the ts phenotype and was unable to suppress the Ino-phenotype of rpo26-31.", "output": {"entities": {"gene": [{"text": "scs32", "start": 7, "end": 12}, {"text": "rpo26-31", "start": 104, "end": 112}]}}, "schema": []}
{"input": "In contrast, both Sp1 and ETS proteins are required to bring about full promoter activity in the Surf-1 direction.", "output": {"entities": {"gene": [{"text": "Sp1", "start": 18, "end": 21}, {"text": "ETS proteins", "start": 26, "end": 38}, {"text": "Surf-1", "start": 97, "end": 103}]}}, "schema": []}
{"input": "We have subcloned into pBR322 deoxyribonucleic acid (DNA) sequences mapping either in the coding region, the 5' spacer, or the 3' spacer of the H2B histone gene.", "output": {"entities": {"gene": [{"text": "H2B histone gene", "start": 144, "end": 160}]}}, "schema": []}
{"input": "The combination of hydralazine hydrochloride and isosorbide dinitrate also improves survival, but direct comparison of both regimens provided evidence for a less favourable effect than that of the ACE inhibitors.", "output": {"entities": {"gene": [{"text": "ACE", "start": 197, "end": 200}]}}, "schema": []}
{"input": "To address mechanisms that define interactions of Site II regulatory factors with this cell cycle control element, we have investigated these determinants of transcriptional regulation at the G1/S phase transition in FDC-P1 hematopoietic progenitor cells.", "output": {"entities": {"gene": [{"text": "Site II regulatory factors", "start": 50, "end": 76}]}}, "schema": []}
{"input": "The goal of this study was to identify neuronal cell cultures that express RC3/neurogranin, to check whether they are sensitive to T3, and to examine the mechanism of regulation.", "output": {"entities": {"gene": [{"text": "RC3", "start": 75, "end": 78}, {"text": "neurogranin", "start": 79, "end": 90}]}}, "schema": []}
{"input": "Their circadian responses to both photic and non-photic cues were then tested.", "output": {"entities": {}}, "schema": []}
{"input": "Human Duo contains a guanine nucleotide exchange factor (GEF) domain that is likely to be rac1-specific, a pleckstrin homology (PH) domain and spectrin-like repeat units.", "output": {"entities": {"gene": [{"text": "Human Duo", "start": 0, "end": 9}, {"text": "guanine nucleotide exchange factor", "start": 21, "end": 55}, {"text": "GEF", "start": 57, "end": 60}, {"text": "rac1", "start": 90, "end": 94}, {"text": "pleckstrin homology", "start": 107, "end": 126}, {"text": "PH", "start": 128, "end": 130}, {"text": "spectrin-like repeat units", "start": 143, "end": 169}]}}, "schema": []}
{"input": "ArgR was shown to be a dimer of two equal subunits, each with a molecular mass of 37, 000 Da.", "output": {"entities": {"gene": [{"text": "ArgR", "start": 0, "end": 4}]}}, "schema": []}
{"input": "Plasma leptin concentrations were higher in women than men, even after the adjustment for differences in fat mass (28 +/-3 ng/ml for women vs.", "output": {"entities": {"gene": [{"text": "Plasma leptin", "start": 0, "end": 13}]}}, "schema": []}
{"input": "Consistent with effects on STAT activation, altered SHP-1 expression also affected EGF-induced activation of the mitogen-activated protein kinase pathway; expression of SHP-1-(Cys--> Ser) inhibited activity of MEK by approximately 25%, whereas expression of SHP-1 resulted in a approximately 25% increase.", "output": {"entities": {"gene": [{"text": "STAT", "start": 27, "end": 31}, {"text": "SHP-1", "start": 52, "end": 57}, {"text": "EGF", "start": 83, "end": 86}, {"text": "mitogen-activated protein kinase", "start": 113, "end": 145}, {"text": "SHP-1-(Cys--> Ser)", "start": 169, "end": 187}, {"text": "MEK", "start": 210, "end": 213}, {"text": "SHP-1", "start": 258, "end": 263}]}}, "schema": []}
{"input": "This interaction involved the SH3 region of p50 (csk) and a proline-rich region (PPPLPERTPESFVLADM) outside the catalytic region of PTP-PEST.", "output": {"entities": {"gene": [{"text": "SH3 region", "start": 30, "end": 40}, {"text": "p50", "start": 44, "end": 47}, {"text": "csk", "start": 49, "end": 52}, {"text": "PTP", "start": 132, "end": 135}]}}, "schema": []}
{"input": "Following 2. 5 Gy, HbO2 changes were minimal.", "output": {"entities": {"gene": [{"text": "HbO2", "start": 19, "end": 23}]}}, "schema": []}
{"input": "Among 38 patients with inducible reentrant VTs who underwent electrophysiologic study (EPS), 10 VTs of six patients were selected.", "output": {"entities": {}}, "schema": []}
{"input": "The cycle length of induced VT (n = 10 VTs) was 380 +/-41 msec.", "output": {"entities": {}}, "schema": []}
{"input": "Transient hyperammonaemia in an adult German shepherd dog.", "output": {"entities": {}}, "schema": []}
{"input": "We established that the 2. 6 kb mRNA V-1 and the 2. 3 kb GGT mRNA V-2 derive, by alternate splicing, from a primary transcript initiated on a distal promoter on the rat GGT gene.", "output": {"entities": {"gene": [{"text": "GGT", "start": 57, "end": 60}, {"text": "rat GGT gene", "start": 165, "end": 177}]}}, "schema": []}
{"input": "A specific distal promoter controls gamma-glutamyl transpeptidase gene expression in undifferentiated rat transformed liver cells.", "output": {"entities": {"gene": [{"text": "gamma-glutamyl transpeptidase gene", "start": 36, "end": 70}]}}, "schema": []}
{"input": "These repressor sites are pyrimidine rich and bind avidly to the polypyrimidine tract binding protein (PTB) in HeLa nuclear extracts as determined by UV crosslinking/competition assays.", "output": {"entities": {"gene": [{"text": "polypyrimidine tract binding protein", "start": 65, "end": 101}, {"text": "PTB", "start": 103, "end": 106}]}}, "schema": []}
{"input": "For higher expression of lipA in S. lividans, the gene was cloned next to the strong aphII promoter.", "output": {"entities": {"gene": [{"text": "lipA", "start": 25, "end": 29}, {"text": "aphII promoter", "start": 85, "end": 99}]}}, "schema": []}
{"input": "Within a 135-bp core homology region, the human HS12 enhancers are approximately 90% identical to the murine homolog and include several motifs previously demonstrated to be important for function of the murine enhancer; additional segments of high sequence conservation suggest the possibility of previously unrecognized functional motifs.", "output": {"entities": {"gene": [{"text": "human HS12 enhancers", "start": 42, "end": 62}]}}, "schema": []}
{"input": "The two cysteine residues located in this additional region may be involved in the formation of a disulfide bridge associated with the activation process of the catalytic activity.", "output": {"entities": {}}, "schema": []}
{"input": "The por gene has been expressed, for the first time, in anaerobically grown Escherichia coli behind the isopropyl-beta-D-thiogalactopyranoside-inducible tac promoter, resulting in the production of POR in its active form.", "output": {"entities": {"gene": [{"text": "por gene", "start": 4, "end": 12}, {"text": "tac promoter", "start": 153, "end": 165}, {"text": "POR", "start": 198, "end": 201}]}}, "schema": []}
{"input": "When the downstream operator was altered, there was a fourfold reduction in reporter enzyme levels.", "output": {"entities": {}}, "schema": []}
{"input": "The ORF3 mutant produced reduced levels of tabtoxin, indicating that ORF3 may have a role in T beta L biosynthesis.", "output": {"entities": {"gene": [{"text": "tabtoxin", "start": 43, "end": 51}, {"text": "T beta L", "start": 93, "end": 101}]}}, "schema": []}
{"input": "Refined Cox models using a CD4 count of 150/microL rather than 200/microL to distinguish I0 and I1 yielded a simplified model with better fit to the observed data.", "output": {"entities": {"gene": [{"text": "CD4", "start": 27, "end": 30}]}}, "schema": []}
{"input": "However, the published reports consist of a small number of patients and limited data.", "output": {"entities": {}}, "schema": []}
{"input": "These transcripts contain the 5' ends of mature UbCRBP mRNAs; extend through UbCRBP, across the intergenic region, and a significant distance 3' into the enolase gene.", "output": {"entities": {"gene": [{"text": "UbCRBP mRNAs", "start": 48, "end": 60}, {"text": "UbCRBP", "start": 77, "end": 83}, {"text": "enolase gene", "start": 154, "end": 166}]}}, "schema": []}
{"input": "The distribution of cryptosporidia in the intestine and number of cryptosporidia per ileal villus on different DPI were also estimated for detailed characterization of the infection in kids as a model for experimental cryptosporidiosis.", "output": {"entities": {}}, "schema": []}
{"input": "As a result, the subendocardial/subepicardial blood flow ratio (ENDO/EPI) increased from 0. 44 +/-0. 09 during control stenosis to 0. 85 +/-0. 13 after ITF 1129 (10 micrograms/kg/min i. v.) and to 0. 81 +/-0. 12 after NTG.", "output": {"entities": {}}, "schema": []}
{"input": "Proteasomes are the multisubunit protease involved in the generation of peptides presented by MHC class I molecules.", "output": {"entities": {"gene": [{"text": "MHC class I molecules", "start": 94, "end": 115}]}}, "schema": []}
{"input": "Takahashi, H.", "output": {"entities": {}}, "schema": []}
{"input": "For sputum interleukin-8 there was an estimated true treatment median difference of 142 pg/ml (95% confidence interval (CI) 8 to 2866 pg/ml) in favour of placebo; while for maximal expiratory flow at 25% (MEF25%) remaining forced vital capacity predicted for sex and height there was a 15 percentage points (pp) (95% CI 4 to 26 pp) mean treatment difference in favour of placebo.", "output": {"entities": {"gene": [{"text": "sputum interleukin-8", "start": 4, "end": 24}]}}, "schema": []}
{"input": "However, although deletion of Fp1 in the hCRBP1 gene yielded increased CAT activity, pointing toward a negative regulatory function exerted by this element, its insertion upstream of the p12 basal promoter results in an impressive positive stimulation of CAT gene expression.", "output": {"entities": {"gene": [{"text": "Fp1", "start": 30, "end": 33}, {"text": "hCRBP1 gene", "start": 41, "end": 52}, {"text": "CAT", "start": 71, "end": 74}, {"text": "p12 basal promoter", "start": 187, "end": 205}, {"text": "CAT gene", "start": 255, "end": 263}]}}, "schema": []}
{"input": "Gaucher' s disease is a rare metabolic disorder characterized by the lack of beta-glucocerebrosidase enzyme.", "output": {"entities": {"gene": [{"text": "beta-glucocerebrosidase enzyme", "start": 77, "end": 107}]}}, "schema": []}
{"input": "The 9; 22 chromosomal translocation characteristic of CML results in a fused bcr/abl gene and an abnormal fusion protein, p210bcr/abl.", "output": {"entities": {"gene": [{"text": "bcr", "start": 77, "end": 80}, {"text": "abl", "start": 81, "end": 84}, {"text": "p210bcr", "start": 122, "end": 129}, {"text": "abl", "start": 130, "end": 133}]}}, "schema": []}
{"input": "By analyzing the RanGAP activity of a series of recombinantly expressed rna1p mutant derivatives, we show that the highly acidic sequence in the C-terminal domain of both yeast proteins is indispensable for activating Ran-mediated GTP hydrolysis.", "output": {"entities": {"gene": [{"text": "RanGAP", "start": 17, "end": 23}, {"text": "rna1p mutant", "start": 72, "end": 84}, {"text": "Ran", "start": 218, "end": 221}]}}, "schema": []}
{"input": "In the absence of MHC class II, purified soluble D10 TCR bound to Staphylococcus aureus enterotoxin C2 with an association rate of 1. 69 +/-0. 12 x 10 (4) M (-1) sec (-1) and a dissociation rate of 1. 9 +/-0. 47 x 10 (-2) sec (-1), giving a dissociation constant of 1. 1 microM.", "output": {"entities": {"gene": [{"text": "MHC class II", "start": 18, "end": 30}, {"text": "purified soluble D10 TCR", "start": 32, "end": 56}, {"text": "Staphylococcus aureus enterotoxin C2", "start": 66, "end": 102}]}}, "schema": []}
{"input": "Evidence for such peak shifts has been found in the responses of auditory nerve fibers, cochlear microphonics, and the responses of outer hair cells and supporting cells in the cochlea, as well as in basilar membrane vibration measurements, and indirectly, in psychophysical data.", "output": {"entities": {}}, "schema": []}
{"input": "Mnt: Max complexes also efficiently suppress Myc-dependent activation from the same promoter.", "output": {"entities": {"gene": [{"text": "Mnt", "start": 0, "end": 3}, {"text": "Max", "start": 5, "end": 8}, {"text": "Myc", "start": 45, "end": 48}]}}, "schema": []}
{"input": "Assays of total cholesterol as well as the HDL, HDL2, LDL, triglycerides, endothelin-1, lipoprotein (a), estradiol and FSH were also obtained at baseline before receiving ERT and after 3 months of ERT.", "output": {"entities": {"gene": [{"text": "HDL", "start": 43, "end": 46}, {"text": "HDL2", "start": 48, "end": 52}, {"text": "LDL", "start": 54, "end": 57}, {"text": "endothelin-1", "start": 74, "end": 86}, {"text": "lipoprotein (a)", "start": 88, "end": 103}, {"text": "FSH", "start": 119, "end": 122}]}}, "schema": []}
{"input": "Six tandem repeats of the P element linked to the SV40 promoter responded to phorbol 12-myristate 13-acetate, while that of other elements did not.", "output": {"entities": {"gene": [{"text": "P element", "start": 26, "end": 35}, {"text": "SV40 promoter", "start": 50, "end": 63}]}}, "schema": []}
{"input": "The distributed current density J is calculated within the volume defined by the motor unit.", "output": {"entities": {}}, "schema": []}
{"input": "The cleavage dipeptides of C1YVV NIa protease are Q (E)/S (A, G).", "output": {"entities": {"gene": [{"text": "C1YVV NIa protease", "start": 27, "end": 45}]}}, "schema": []}
{"input": "However, we were unable to identify a p4 molecule.", "output": {"entities": {"gene": [{"text": "p4", "start": 38, "end": 40}]}}, "schema": []}
{"input": "(iv) The accumulation of cyclin D3 protein in Vero cells infected with an alpha0 deletion mutant was reduced relative to that of cells infected with wild-type virus or a recombinant virus in which the deleted alpha0 sequences were restored.", "output": {"entities": {"gene": [{"text": "cyclin D3 protein", "start": 25, "end": 42}, {"text": "alpha0 deletion mutant", "start": 74, "end": 96}, {"text": "alpha0 sequences", "start": 209, "end": 225}]}}, "schema": []}
{"input": "We report the preliminary biochemical characterization of the T antigens encoded by three SV40 mutants, 5030, 5031, and 5061, each of which have altered residues within or near the ATP binding pocket.", "output": {"entities": {"gene": [{"text": "T antigens", "start": 62, "end": 72}]}}, "schema": []}
{"input": "These effects were abrogated by co-expression of kinase-deficient PKC zeta and inhibition of phosphatidylinositol 3-kinase p85alpha-p110 by wortmannin, LY294002 and a dominant-negative mutant of p85alpha.", "output": {"entities": {"gene": [{"text": "kinase-deficient PKC zeta", "start": 49, "end": 74}, {"text": "phosphatidylinositol 3-kinase p85alpha", "start": 93, "end": 131}, {"text": "p110", "start": 132, "end": 136}, {"text": "p85alpha", "start": 195, "end": 203}]}}, "schema": []}
{"input": "Protein phosphatase 2A is a critical regulator of protein kinase C zeta signaling targeted by SV40 small t to promote cell growth and NF-kappaB activation.", "output": {"entities": {"gene": [{"text": "Protein phosphatase 2A", "start": 0, "end": 22}, {"text": "protein kinase C zeta", "start": 50, "end": 71}, {"text": "SV40 small t", "start": 94, "end": 106}, {"text": "NF-kappaB", "start": 134, "end": 143}]}}, "schema": []}
{"input": "Interestingly, the RXRalphaF318A constitutive activity generated within heterodimers in the presence of BMS614 requires the integrity of both RXR and RAR AF-2 domains.", "output": {"entities": {"gene": [{"text": "RXRalphaF318A", "start": 19, "end": 32}, {"text": "RXR", "start": 142, "end": 145}, {"text": "RAR", "start": 150, "end": 153}]}}, "schema": []}
{"input": "These introns contain only single snoRNA genes and their processing involves exonucleolytic release of the snoRNA from debranched intron lariats.", "output": {"entities": {"gene": [{"text": "snoRNA genes", "start": 34, "end": 46}]}}, "schema": []}
{"input": "Recent studies have shown that the Src homology-2 (SH2) domain-containing protein-tyrosine phosphatase, SHP-2, associates with the cytoplasmic domain of PECAM-1 as it becomes tyrosine-phosphorylated during platelet aggregation: a process that can be mimicked in part by small synthetic phosphopeptides corresponding to the cytoplasmic domain of PECAM-1 encompassing tyrosine residues Tyr-663 or Tyr-686.", "output": {"entities": {"gene": [{"text": "Src homology-2", "start": 35, "end": 49}, {"text": "SH2", "start": 51, "end": 54}, {"text": "protein-tyrosine phosphatase", "start": 74, "end": 102}, {"text": "SHP-2", "start": 104, "end": 109}, {"text": "PECAM-1", "start": 153, "end": 160}, {"text": "PECAM-1", "start": 345, "end": 352}]}}, "schema": []}
{"input": "Underlying the clustering of these risk variables were three factors.", "output": {"entities": {}}, "schema": []}
{"input": "Supplementation was stopped when pl-ALB reached 2. 0 g/dL.", "output": {"entities": {"gene": [{"text": "pl-ALB", "start": 33, "end": 39}]}}, "schema": []}
{"input": "Detection of airborne Mycobacterium tuberculosis by air filtration and polymerase chain reaction.", "output": {"entities": {}}, "schema": []}
{"input": "These findings show that EBP50 is a physiologically relevant ezrin binding protein.", "output": {"entities": {"gene": [{"text": "EBP50", "start": 25, "end": 30}, {"text": "ezrin binding protein", "start": 61, "end": 82}]}}, "schema": []}
{"input": "This family of proteins binds GC-rich motifs widely distributed in gene promoters, resulting in distinct activation or repression of transcriptional activities.", "output": {"entities": {}}, "schema": []}
{"input": "Deletion of the POR2 gene alone had no detectable phenotype, while yeasts with deletions of both the POR1 and POR2 genes were viable and able to grow on glycerol at 30 degrees C, albeit more slowly than delta por1 single mutants.", "output": {"entities": {"gene": [{"text": "POR2 gene", "start": 16, "end": 25}, {"text": "POR1", "start": 101, "end": 105}, {"text": "POR2 genes", "start": 110, "end": 120}, {"text": "delta por1 single mutants", "start": 203, "end": 228}]}}, "schema": []}
{"input": "Furthermore, our novel observation that expression of a highly activated FGFR3 kinase domain is able to morphologically transform fibroblasts suggests that dysregulation of FGFR3 has the potential to play a role in human neoplasia.", "output": {"entities": {"gene": [{"text": "FGFR3 kinase domain", "start": 73, "end": 92}, {"text": "FGFR3", "start": 173, "end": 178}]}}, "schema": []}
{"input": "Involvement of AP-2 in regulation of the R-FABP gene in the developing chick retina.", "output": {"entities": {"gene": [{"text": "AP-2", "start": 15, "end": 19}, {"text": "R-FABP gene", "start": 41, "end": 52}]}}, "schema": []}
{"input": "However, Cbf5p was found to be nucleolar and is highly homologous to the rat nucleolar protein NAP57, which coimmunoprecipitates with Nopp140 and which is postulated to be involved in nucleolar-cytoplasmic shuttling (U.", "output": {"entities": {"gene": [{"text": "Cbf5p", "start": 9, "end": 14}, {"text": "rat nucleolar protein NAP57", "start": 73, "end": 100}, {"text": "Nopp140", "start": 134, "end": 141}]}}, "schema": []}
{"input": "This newly described organism was difficult to identify due to discrepancies between the Vitek and API 20E identification systems.", "output": {"entities": {}}, "schema": []}
{"input": "Ig heavy chain class switching is directed by cytokines inducing transcription from unrearranged CH genes.", "output": {"entities": {"gene": [{"text": "Ig heavy chain", "start": 0, "end": 14}, {"text": "CH genes", "start": 97, "end": 105}]}}, "schema": []}
{"input": "The available data suggest that the NF kappa B2 nucleoprotein complex may cooperate with DNA-bound STAT6 to achieve IL-4-dependent activation of the human IgE germline gene.", "output": {"entities": {"gene": [{"text": "NF kappa B2 nucleoprotein complex", "start": 36, "end": 69}, {"text": "STAT6", "start": 99, "end": 104}, {"text": "IL-4", "start": 116, "end": 120}, {"text": "human IgE germline gene", "start": 149, "end": 172}]}}, "schema": []}
{"input": "EXERCISE IN THE TERRESTRIAL CHRISTMAS ISLAND RED CRAB GECARCOIDEA NATALIS-ENERGETICS OF LOCOMOTION", "output": {"entities": {}}, "schema": []}
{"input": "THE SCALING OF SONG FREQUENCY IN CICADAS", "output": {"entities": {}}, "schema": []}
{"input": "In this study we have introduced mutations into the corresponding elements of two cox3 promoters and show that while the core element is essential for cox3 promoter activity, upstream element mutations have little or no effect.", "output": {"entities": {"gene": [{"text": "cox3 promoters", "start": 82, "end": 96}, {"text": "cox3 promoter", "start": 151, "end": 164}]}}, "schema": []}
{"input": "We found that multiple tumor suppressor genes (e. g., p53, DCC, APC, MCC, BRCA1, and WAF1/CIP1) were inactivated at different frequencies via various mechanisms [e. g., loss of heterozygosity (LOH), loss of expression (LOE), mutation, and inactivation by cellular binding protein].", "output": {"entities": {"gene": [{"text": "p53", "start": 54, "end": 57}, {"text": "DCC", "start": 59, "end": 62}, {"text": "APC", "start": 64, "end": 67}, {"text": "MCC", "start": 69, "end": 72}, {"text": "BRCA1", "start": 74, "end": 79}, {"text": "WAF1", "start": 85, "end": 89}, {"text": "CIP1", "start": 90, "end": 94}]}}, "schema": []}
{"input": "The histidine-tagged gene, rpoCHIS, was used to replace the wild-type allele in the chromosome of S. coelicolor and S. lividans.", "output": {"entities": {"gene": [{"text": "rpoCHIS", "start": 27, "end": 34}]}}, "schema": []}
{"input": "Because the deletion included the TK gene, selection with gancyclovir against cells not having undergone recombination was possible.", "output": {"entities": {"gene": [{"text": "TK gene", "start": 34, "end": 41}]}}, "schema": []}
{"input": "Lack of controlled prospective studies of sleep electroencephalograms (EEG), and the use of medication, in children with developmental dysphasia, may deny appropriate treatment strategies to children with severe developmental speech and language disorders.", "output": {"entities": {}}, "schema": []}
{"input": "Widening of the abdominal aortic wall on an ultrasound examination was the key to the incidental diagnosis of a clinically unsuspected type B dissection.", "output": {"entities": {}}, "schema": []}
{"input": "Fermentation process after supplementation of nitrate, nitrite, lactic acid bacteria and formic acid", "output": {"entities": {}}, "schema": []}
{"input": "Substrates include the p21 (ras) proteins, nuclear lamins, and a series of retinal proteins.", "output": {"entities": {"gene": [{"text": "p21", "start": 23, "end": 26}, {"text": "ras", "start": 28, "end": 31}, {"text": "nuclear lamins", "start": 43, "end": 57}]}}, "schema": []}
{"input": "Ovaries of 10 animals per group from 16 studies in CD-1 mice and 1 study each in C3H and C57BL/6 mice were sectioned serially at 6 microm.", "output": {"entities": {}}, "schema": []}
{"input": "The Trx-CT fusion protein was produced less efficiently (20% of total soluble cellular protein).", "output": {"entities": {"gene": [{"text": "Trx", "start": 4, "end": 7}, {"text": "CT", "start": 8, "end": 10}]}}, "schema": []}
{"input": "A data base homology search revealed that the predicted ER1 amino acid sequence contains three regions of similarity to the rat and human proteins encoded by the metastasis-associated gene, mta1, and two regions of similarity to the Caenorhabditis elegans sequence that is similar to mta1.", "output": {"entities": {"gene": [{"text": "ER1", "start": 56, "end": 59}, {"text": "mta1", "start": 190, "end": 194}, {"text": "mta1", "start": 284, "end": 288}]}}, "schema": []}
{"input": "The sequenced cDNA predicts a 704-amino acid protein 80% identical to human progelatinase B.", "output": {"entities": {"gene": [{"text": "human progelatinase B", "start": 70, "end": 91}]}}, "schema": []}
{"input": "The inhibition by cytosolic Ca2 + was caused by a decrease in cooperativity and by a shift in EC50 toward higher InsP3 concentrations.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: The standardised mortality ratio (SMR) for all malignant neoplasms was 94 (95% CI 74 to 118).", "output": {"entities": {}}, "schema": []}
{"input": "Sequence analysis of this region revealed three eight-bp repetitive elements, the deletion of which restored wild-type levels of luciferase activity to the-916-bp reporter plasmid.", "output": {"entities": {"gene": [{"text": "luciferase", "start": 129, "end": 139}]}}, "schema": []}
{"input": "Using 5' RACE and reverse transcription-PCR (RT-PCR) methodologies, we cloned these sequences from brain and placenta and found this material to be composed of alternatively spliced exons using a previously reported noncoding exon (1A) and a novel 97-bp noncoding exon (1B).", "output": {"entities": {}}, "schema": []}
{"input": "This is the first study in which mutation screening has been performed for both the EXT1 and EXT2 genes prior to any linkage analysis.", "output": {"entities": {"gene": [{"text": "EXT1", "start": 84, "end": 88}, {"text": "EXT2 genes", "start": 93, "end": 103}]}}, "schema": []}
{"input": "Positron emission tomography radioligands for dopamine transporters and studies in human and nonhuman primates.", "output": {"entities": {"gene": [{"text": "dopamine transporters", "start": 46, "end": 67}]}}, "schema": []}
{"input": "Expression from this element is regulated by a heteromeric protein complex containing ubiquitous (i. e. the E2A-and HEB-encoded proteins) and islet-enriched members of the bHLH family.", "output": {"entities": {"gene": [{"text": "E2A", "start": 108, "end": 111}, {"text": "HEB-encoded proteins", "start": 116, "end": 136}, {"text": "bHLH family", "start": 172, "end": 183}]}}, "schema": []}
{"input": "Thus, the CCAAT box also has tissue-specific characteristics that assist in targeting expression of the alpha-subunit gene to trophoblasts.", "output": {"entities": {"gene": [{"text": "alpha-subunit gene", "start": 104, "end": 122}]}}, "schema": []}
{"input": "U4/U6 snRNP is one of four essential small nuclear ribonucleoprotein (snRNP) particles (U1, U2, U5 and U4/U6) present in the spliceosome.", "output": {"entities": {"gene": [{"text": "U4", "start": 0, "end": 2}, {"text": "U6", "start": 3, "end": 5}, {"text": "U1", "start": 88, "end": 90}, {"text": "U2", "start": 92, "end": 94}, {"text": "U5", "start": 96, "end": 98}, {"text": "U4", "start": 103, "end": 105}, {"text": "U6", "start": 106, "end": 108}]}}, "schema": []}
{"input": "Hprp3p is a 77 kDa protein, which is homologous to the Saccharomyces cerevisiae splicing factor Prp3p.", "output": {"entities": {"gene": [{"text": "Hprp3p", "start": 0, "end": 6}, {"text": "Saccharomyces cerevisiae splicing factor Prp3p", "start": 55, "end": 101}]}}, "schema": []}
{"input": "The growth-promoting properties of the retroviral v-erbA oncogene, a highly mutated version of the chicken thyroid hormone receptor (TR) alpha, have so far exclusively been linked to dominant repression of the antimitogenic roles of TR and retinoic acid receptors.", "output": {"entities": {"gene": [{"text": "retroviral v-erbA oncogene", "start": 39, "end": 65}, {"text": "chicken thyroid hormone receptor (TR) alpha", "start": 99, "end": 142}, {"text": "TR", "start": 233, "end": 235}, {"text": "retinoic acid receptors", "start": 240, "end": 263}]}}, "schema": []}
{"input": "We cloned a complete cDNA (2. 9 kb) for HET from an MCF-7 cDNA library.", "output": {"entities": {"gene": [{"text": "HET", "start": 40, "end": 43}]}}, "schema": []}
{"input": "The most common grade 3 toxicity was neutropenia, thrombocytopenia, and parasthesias (observed in < 10% of cycles).", "output": {"entities": {}}, "schema": []}
{"input": "Serum concentrations of E2 and TBOH were measured on d 0, 1, 3, 5, 7, 13, 21, 28, 42, 56, 84, 112, and 140 in finishing heifers administered the following treatments: 1) control; 2) MGA,. 5 mg per heifer daily; 3) Revalor-H (140 mg TBA + 14 mg E2); 4) Revalor-H + MGA; 5) Finaplix-H (200 mg TBA); and 6) Finaplix-H + MGA.", "output": {"entities": {}}, "schema": []}
{"input": "Serum E2 concentrations increased numerically two-to threefold from d 56 to 140 in controls fed MGA, compared with controls not fed MGA.", "output": {"entities": {}}, "schema": []}
{"input": "Interferon Regulatory Factor (IRF)-1 has been characterized as an important growth regulatory and immunomodulatory transcription factor.", "output": {"entities": {"gene": [{"text": "Interferon Regulatory Factor (IRF)-1", "start": 0, "end": 36}]}}, "schema": []}
{"input": "The genomic structure of brk consists of 8 exons, whose boundaries are distinct from other non-receptor PTK family members, again indicating a structural and functional divergence.", "output": {"entities": {"gene": [{"text": "brk", "start": 25, "end": 28}, {"text": "PTK family", "start": 104, "end": 114}]}}, "schema": []}
{"input": "We have previously reported that expression of a tumour derived brk cDNA in mouse embryonic fibroblasts and human mammary epithelial cells supports anchorage independent growth, and in the latter potentiates the mitogenic response to epidermal growth factor.", "output": {"entities": {"gene": [{"text": "brk cDNA", "start": 64, "end": 72}, {"text": "epidermal growth factor", "start": 234, "end": 257}]}}, "schema": []}
{"input": "Anti-hepatitis A virus (HAV) titer after vaccination was measured in 83 HIV-positive and 39 HIV-negative men.", "output": {"entities": {"gene": [{"text": "Anti-hepatitis A", "start": 0, "end": 16}]}}, "schema": []}
{"input": "One skull does not a species make.", "output": {"entities": {}}, "schema": []}
{"input": "Surprisingly, calf thymus CstF contained an additional, novel form of the 64-kDa subunit with a molecular mass of 70 kDa.", "output": {"entities": {"gene": [{"text": "calf thymus CstF", "start": 14, "end": 30}]}}, "schema": []}
{"input": "Our results favor the possibility that the Drosophila EGF receptor DER/Egfr expressed by the EMA cells functions as a receptor for Vein.", "output": {"entities": {"gene": [{"text": "Drosophila EGF receptor DER", "start": 43, "end": 70}, {"text": "Egfr", "start": 71, "end": 75}, {"text": "Vein", "start": 131, "end": 135}]}}, "schema": []}
{"input": "PATIENTS AND METHODS: In 807 consecutive patients from the Chilean National Registry of Acute Myocardial Infarction we analyzed the resolution of chest pain and ST segment elevation over 50% within the first 90 min, abrupt CK rise within 8 h and T wave inversion in infarct related EKG leads within the first 24 h after thrombolysis.", "output": {"entities": {"gene": [{"text": "CK", "start": 223, "end": 225}]}}, "schema": []}
{"input": "Because of the operon structure of this organism, traditional methods such as insertional mutagenesis run the risk of introducing polar effects on downstream genes or creating secondary mutations elsewhere in the genome.", "output": {"entities": {}}, "schema": []}
{"input": "It has been proposed that the parCBA operon encodes a plasmid partitioning system (M.", "output": {"entities": {"gene": [{"text": "parCBA operon", "start": 30, "end": 43}]}}, "schema": []}
{"input": "Furthermore, the insertion of the ColE1 cer site into the RK2 plasmid deleted for the par region failed to stabilize the plasmid in the MC1061K strain, indicating that the multimer resolution activity encoded by parCBA is not by itself responsible for the stabilization activity observed for this operon.", "output": {"entities": {"gene": [{"text": "ColE1 cer site", "start": 34, "end": 48}, {"text": "parCBA", "start": 212, "end": 218}]}}, "schema": []}
{"input": "To examine the basis for the apparent differences in postsegregational killing between the two E. coli strains, transformation assays were carried out to determine the relative sensitivities of the strains to the ParE toxin protein.", "output": {"entities": {"gene": [{"text": "ParE toxin protein", "start": 213, "end": 231}]}}, "schema": []}
{"input": "Splice-junction elements and intronic sequences regulate alternative splicing of the Drosophila myosin heavy chain gene transcript.", "output": {"entities": {"gene": [{"text": "myosin heavy chain gene", "start": 96, "end": 119}]}}, "schema": []}
{"input": "Nucleotide sequence analysis of R has revealed similarities to the R1 plasmid found in some South American maize races with RU cytoplasm, to the M1 plasmid found in one source of Zea luxurians teosinte, to the atp9 mitochondrial gene and its 3' flanking sequence, and also to a region 3' to the orf221 gene.", "output": {"entities": {"gene": [{"text": "atp9 mitochondrial gene", "start": 210, "end": 233}, {"text": "orf221 gene", "start": 295, "end": 306}]}}, "schema": []}
{"input": "We have measured the kinetics of the recovery of mRNA synthesis in the inducible GAL10 and RNR3 genes after exposure of yeast cells to ultraviolet (UV) radiation.", "output": {"entities": {"gene": [{"text": "GAL10", "start": 81, "end": 86}, {"text": "RNR3 genes", "start": 91, "end": 101}]}}, "schema": []}
{"input": "Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin.", "output": {"entities": {"gene": [{"text": "human phosphoinositide 3-kinase", "start": 13, "end": 44}, {"text": "C2", "start": 52, "end": 54}]}}, "schema": []}
{"input": "Ea value was calculated as the ratio of the steady-state end-systolic aortic pressure (ESAP) to stroke volume (thermodilution).", "output": {"entities": {}}, "schema": []}
{"input": "Functional analysis of promoter activity of the 5'-flanking region of cyclin D2 suggested that the region-1, 100 to-805 including C/EBP, PEA3, AP2, NF-Y, c-Myc, and Sp1 may have a major positive regulatory activity for expression of cyclin D2.", "output": {"entities": {"gene": [{"text": "cyclin D2", "start": 70, "end": 79}, {"text": "C/EBP", "start": 130, "end": 135}, {"text": "PEA3", "start": 137, "end": 141}, {"text": "AP2", "start": 143, "end": 146}, {"text": "NF-Y", "start": 148, "end": 152}, {"text": "c-Myc", "start": 154, "end": 159}, {"text": "Sp1", "start": 165, "end": 168}, {"text": "cyclin D2", "start": 233, "end": 242}]}}, "schema": []}
{"input": "Effect of alcohol on minimal effective nCPAP pressure", "output": {"entities": {}}, "schema": []}
{"input": "In contrast, resensitization of a sequestration-impaired beta2AR mutant (Y326A) was reestablished following the overexpression of either GRK2 or beta-arrestin 1.", "output": {"entities": {"gene": [{"text": "beta2AR", "start": 57, "end": 64}, {"text": "GRK2", "start": 137, "end": 141}, {"text": "beta-arrestin 1", "start": 145, "end": 160}]}}, "schema": []}
{"input": "The medium chains of these complexes, mu1 and mu2, have been implicated in two types of interaction: assembly with the beta1 and beta2 chains of the corresponding complexes and recognition of tyrosine-based sorting signals.", "output": {"entities": {"gene": [{"text": "mu1", "start": 38, "end": 41}, {"text": "mu2", "start": 46, "end": 49}, {"text": "beta1 and beta2 chains", "start": 119, "end": 141}]}}, "schema": []}
{"input": "Osmotic shock stimulates GLUT4 translocation in 3T3L1 adipocytes by a novel tyrosine kinase pathway.", "output": {"entities": {"gene": [{"text": "GLUT4", "start": 25, "end": 30}, {"text": "tyrosine kinase", "start": 76, "end": 91}]}}, "schema": []}
{"input": "We also identified Sp1, Sp3, and NGFI-A/Egr-1 as the primary nuclear transcription factors binding to TRE1 which mediate Tax responsiveness.", "output": {"entities": {"gene": [{"text": "Sp1", "start": 19, "end": 22}, {"text": "Sp3", "start": 24, "end": 27}, {"text": "NGFI-A", "start": 33, "end": 39}, {"text": "Egr-1", "start": 40, "end": 45}, {"text": "TRE1", "start": 102, "end": 106}, {"text": "Tax", "start": 121, "end": 124}]}}, "schema": []}
{"input": "Interestingly, segment nesting differentially increases the copy number of genes encoded by segment W, suggesting that the unusual genomic organization of PDVs may be directly linked to the unique functions of this virus in its obligate mutualistic association with parasitic wasps.", "output": {"entities": {}}, "schema": []}
{"input": "Processivity of DNA synthesis by the mutant holoenzyme containing pcna-79 was unaffected on poly (dA) x oligo (dT) but was dramatically reduced on a natural template with secondary structure.", "output": {"entities": {"gene": [{"text": "pcna-79", "start": 66, "end": 73}]}}, "schema": []}
{"input": "Alanine substitution mutations in the Zta activation domain which eliminate the ability of Zta to stimulate the D-A complex were examined.", "output": {"entities": {"gene": [{"text": "Zta activation domain", "start": 38, "end": 59}, {"text": "Zta", "start": 91, "end": 94}, {"text": "D-A complex", "start": 112, "end": 123}]}}, "schema": []}
{"input": "The Scm and ph proteins share a homology domain with 38% identity over a length of 65 amino acids, termed the SPM domain, that is located at their respective C termini.", "output": {"entities": {"gene": [{"text": "Scm", "start": 4, "end": 7}, {"text": "ph", "start": 12, "end": 14}]}}, "schema": []}
{"input": "It has been previously shown that genes transcribed by RNA polymerase II (RNAP II) are subject to position effect variegation when located near yeast telomeres.", "output": {"entities": {"gene": [{"text": "RNA polymerase II", "start": 55, "end": 72}, {"text": "RNAP II", "start": 74, "end": 81}]}}, "schema": []}
{"input": "Likewise, rad6-delta reduces silencing of the telomere-located RNAP II-transcribed genes URA3 and ADE2.", "output": {"entities": {"gene": [{"text": "rad6-delta", "start": 10, "end": 20}, {"text": "telomere-located RNAP II-transcribed genes URA3", "start": 46, "end": 93}, {"text": "ADE2", "start": 98, "end": 102}]}}, "schema": []}
{"input": "The amplitude of detrusor contractions at 6, 12, and 24 hours showed no significant difference from that in the controls.", "output": {"entities": {}}, "schema": []}
{"input": "In the predicted transmembrane domain, Casr-rs2 and Casr-rs3 are 95% identical to Casr-rs1.", "output": {"entities": {"gene": [{"text": "Casr-rs2", "start": 39, "end": 47}, {"text": "Casr-rs3", "start": 52, "end": 60}, {"text": "Casr-rs1", "start": 82, "end": 90}]}}, "schema": []}
{"input": "PET activation studies are performed widely to study human brain function.", "output": {"entities": {}}, "schema": []}
{"input": "F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex.", "output": {"entities": {"gene": [{"text": "F-box proteins", "start": 0, "end": 14}, {"text": "SCF ubiquitin", "start": 75, "end": 88}, {"text": "ligase", "start": 89, "end": 95}]}}, "schema": []}
{"input": "In the context of liver allograft shortage, our results suggest that an ELT should not be performed in patients with cardiac failure, more than two OSF, or an APACHE II score higher than 30.", "output": {"entities": {}}, "schema": []}
{"input": "The SH3 domains of Grb2 bound in vitro to specific proline-rich motifs in the HPK1 tail and functioned synergistically to direct the stable binding of Grb2 to HPK1 in transfected Cos1 cells.", "output": {"entities": {"gene": [{"text": "SH3 domains", "start": 4, "end": 15}, {"text": "Grb2", "start": 19, "end": 23}, {"text": "HPK1", "start": 78, "end": 82}, {"text": "Grb2", "start": 151, "end": 155}, {"text": "HPK1", "start": 159, "end": 163}]}}, "schema": []}
{"input": "By far-Western analysis and coimmunoprecipitation studies, we demonstrate that ZNF74 interacts, via its zinc finger domain, with the hyperphosphorylated largest subunit of RNA polymerase II (pol IIo) but not with the hypophosphorylated form.", "output": {"entities": {"gene": [{"text": "ZNF74", "start": 79, "end": 84}, {"text": "RNA polymerase II", "start": 172, "end": 189}, {"text": "pol IIo", "start": 191, "end": 198}]}}, "schema": []}
{"input": "Thus, ZNF74 sublocalization in nuclear domains enriched in pre-mRNA maturating factors, its RNA binding activity, and its direct phosphodependent interaction with the pol IIo, a form of the RNA polymerase functionally associated with pre-mRNA processing, suggest a role for this member of the KRAB multifinger protein family in RNA processing.", "output": {"entities": {"gene": [{"text": "ZNF74", "start": 6, "end": 11}, {"text": "pol IIo", "start": 167, "end": 174}, {"text": "RNA polymerase", "start": 190, "end": 204}, {"text": "KRAB multifinger protein family", "start": 293, "end": 324}]}}, "schema": []}
{"input": "Ki-ras4BVal-12 transfectant cells expressed 2-fold elevated protein levels of the lysosomal cysteine protease cathepsin B but did not up-regulate cathepsin B mRNA expression.", "output": {"entities": {"gene": [{"text": "Ki-ras4BVal-12", "start": 0, "end": 14}, {"text": "lysosomal cysteine protease cathepsin B", "start": 82, "end": 121}, {"text": "cathepsin B mRNA", "start": 146, "end": 162}]}}, "schema": []}
{"input": "The cellular rate of anticoagulant heparan sulfate proteoglycan (HSPGact) generation is determined by the level of a kinetically limiting microsomal activity, HSact conversion activity, which is predominantly composed of the long sought heparan sulfate D-glucosaminyl 3-O-sulfotransferase (3-OST) (Shworak, N.", "output": {"entities": {"gene": [{"text": "anticoagulant heparan sulfate proteoglycan", "start": 21, "end": 63}, {"text": "HSPGact", "start": 65, "end": 72}, {"text": "heparan sulfate D-glucosaminyl 3-O-sulfotransferase", "start": 237, "end": 288}, {"text": "3-OST", "start": 290, "end": 295}]}}, "schema": []}
{"input": "Interestingly, EGF, but not insulin, stimulated tyrosine phosphorylation of c-cbl and its association with Crk-II.", "output": {"entities": {"gene": [{"text": "EGF", "start": 15, "end": 18}, {"text": "insulin", "start": 28, "end": 35}, {"text": "c-cbl", "start": 76, "end": 81}, {"text": "Crk-II", "start": 107, "end": 113}]}}, "schema": []}
{"input": "An end to the lottery.", "output": {"entities": {}}, "schema": []}
{"input": "We previously showed that the N-terminal portion common to various chimeric MLL products, as well as to MLL-LTG9 and MLL-LTG19, localizes in the nuclei, and therefore suggested that it might play an important role in leukemogenesis.", "output": {"entities": {"gene": [{"text": "chimeric MLL products", "start": 67, "end": 88}, {"text": "MLL-LTG9", "start": 104, "end": 112}, {"text": "MLL-LTG19", "start": 117, "end": 126}]}}, "schema": []}
{"input": "Our results suggest that the pattern of blood supply is relevant to the structural organisation of mature lamellar bone around the implant.", "output": {"entities": {}}, "schema": []}
{"input": "Induction of AtP5CS1 mRNA accumulation in salt-treated seedlings involves an immediate early transcriptional response regulated by ABA signalling that is not inhibited by cycloheximide, but abolished by the deficiency of ABA biosynthesis in the aba1 Arabidopsis mutant.", "output": {"entities": {"gene": [{"text": "AtP5CS1 mRNA", "start": 13, "end": 25}, {"text": "aba1 Arabidopsis mutant", "start": 245, "end": 268}]}}, "schema": []}
{"input": "It thus appears that MAPK functions in meiotic maturation by preventing unfertilized eggs from proceeding into parthenogenetic development.", "output": {"entities": {"gene": [{"text": "MAPK", "start": 21, "end": 25}]}}, "schema": []}
{"input": "A positive correlation between serum myoglobin and CA III concentrations (rs = 0. 933, P < 0. 001) was observed in hemodialyzed patients with chronic renal failure.", "output": {"entities": {"gene": [{"text": "serum myoglobin", "start": 31, "end": 46}, {"text": "CA III", "start": 51, "end": 57}]}}, "schema": []}
{"input": "Furthermore, the over-replication phenotype produced by this mutant p65cdc18 is resistant to increased mitotic cyclin/CDK activity, a known inhibitor of over-replication.", "output": {"entities": {"gene": [{"text": "mutant p65cdc18", "start": 61, "end": 76}, {"text": "cyclin", "start": 111, "end": 117}, {"text": "CDK", "start": 118, "end": 121}]}}, "schema": []}
{"input": "Rip1p is inessential, associated with nuclear pore complexes, and structurally related to the FG-nucleoporin family of pore proteins.", "output": {"entities": {"gene": [{"text": "Rip1p", "start": 0, "end": 5}, {"text": "FG-nucleoporin family", "start": 94, "end": 115}]}}, "schema": []}
{"input": "The CNXA domain is similar at the amino acid level to the Escherichia coli moaA gene product, while CNXC is similar to the E. coli moaC product, with both E. coli products encoded by different cistrons.", "output": {"entities": {"gene": [{"text": "Escherichia coli moaA gene product", "start": 58, "end": 92}, {"text": "E. coli moaC product", "start": 123, "end": 143}]}}, "schema": []}
{"input": "Deletions in each of these regions abolish membrane localization of Tiam1 and membrane ruffling, suggesting that they function cooperatively.", "output": {"entities": {"gene": [{"text": "Tiam1", "start": 68, "end": 73}]}}, "schema": []}
{"input": "However, besides the kinase catalytic domain and double leucine/isoleucine zippers, there was no significant homology with known proteins.", "output": {"entities": {}}, "schema": []}
{"input": "RNA polymerase II inhibition increased the binding of ARE (AUBP activity) and poly (U)-Sepharose by cytoplasmic hnRNP A1, while nuclear hnRNP A1 binding was unaffected.", "output": {"entities": {"gene": [{"text": "RNA polymerase II", "start": 0, "end": 17}, {"text": "cytoplasmic hnRNP A1", "start": 100, "end": 120}, {"text": "nuclear hnRNP A1", "start": 128, "end": 144}]}}, "schema": []}
{"input": "Modulation of AUUUA response element binding by heterogeneous nuclear ribonucleoprotein A1 in human T lymphocytes.", "output": {"entities": {"gene": [{"text": "heterogeneous nuclear ribonucleoprotein A1", "start": 48, "end": 90}]}}, "schema": []}
{"input": "Histological slides of one biopsy of each patient (formalin-fixed and paraffin-embedded) were stained with a Modified Giemsa (MG), the Warthin-Starry (WS), and an immunohistochemical method (IMM) using purified polyclonal H. pylori antiserum (DAKO B471).", "output": {"entities": {}}, "schema": []}
{"input": "Their biosynthesis proceeds via linear precursors that become branched by beta1, 6-GlcNAc transferases (IGnT6, GlcNAc to Gal).", "output": {"entities": {"gene": [{"text": "beta1, 6-GlcNAc transferases", "start": 74, "end": 102}]}}, "schema": []}
{"input": "These findings indicate that the t (4; 14) (p16. 3; q32) represents a novel, recurrent chromosomal translocation in MM, and suggest that the FGFR3 gene may be the target of this abnormality and thus contribute to tumorigenesis in MM.", "output": {"entities": {"gene": [{"text": "FGFR3 gene", "start": 141, "end": 151}]}}, "schema": []}
{"input": "In addition, mutation of the Sp1 site also significantly reduced promoter activity.", "output": {"entities": {"gene": [{"text": "Sp1 site", "start": 29, "end": 37}]}}, "schema": []}
{"input": "Amino acid residues of beta 1', alpha A', alpha B', and the loop containing His539 of the RNase H domain interact with the primer strand of the dsDNA.", "output": {"entities": {"gene": [{"text": "RNase H domain", "start": 90, "end": 104}]}}, "schema": []}
{"input": "Moreover, in one patient with a sarcoma who underwent a leg-sparing procedure, no sciatic nerve enlargement was seen postoperatively.", "output": {"entities": {}}, "schema": []}
{"input": "The full length cDNA sequence of a Type I transforming growth factor-beta (TGF-beta) receptor has been isolated from the filarial parasitic nematode Brugia pahangi.", "output": {"entities": {"gene": [{"text": "Type I transforming growth factor-beta (TGF-beta) receptor", "start": 35, "end": 93}]}}, "schema": []}
{"input": "This sequence possessed homology with a methylation-sensitive promoter element, Enh2, present in the LTR of mouse intractisternal A-particles.", "output": {"entities": {}}, "schema": []}
{"input": "Codon optimization for high-level expression of human erythropoietin (EPO) in mammalian cells.", "output": {"entities": {"gene": [{"text": "human erythropoietin", "start": 48, "end": 68}, {"text": "EPO", "start": 70, "end": 73}]}}, "schema": []}
{"input": "Parodoxical rise in urinary albumin levels after treatment of essential hypertension.", "output": {"entities": {"gene": [{"text": "urinary albumin", "start": 20, "end": 35}]}}, "schema": []}
{"input": "20% of total HSL transcripts in human subcutaneous adipocytes.", "output": {"entities": {"gene": [{"text": "HSL transcripts", "start": 13, "end": 28}]}}, "schema": []}
{"input": "Taken together, our data suggest that Rat7p/Nup159p is anchored within the NPC through its coiled-coil region and adjacent sequences.", "output": {"entities": {"gene": [{"text": "Rat7p", "start": 38, "end": 43}, {"text": "Nup159p", "start": 44, "end": 51}]}}, "schema": []}
{"input": "In a group of 13 patients with obliterative arteriopathies of the lower limbs the plasma levels of thrombomodulin (TM), betathromboglobulin (beta-TG), D-dimer (DD) and plasminogen activator-inhibitor (pAI-1) were measured, and compared to the values obtained from 10 healthy volunteers.", "output": {"entities": {"gene": [{"text": "thrombomodulin", "start": 99, "end": 113}, {"text": "TM", "start": 115, "end": 117}, {"text": "betathromboglobulin", "start": 120, "end": 139}, {"text": "beta-TG", "start": 141, "end": 148}, {"text": "plasminogen activator-inhibitor", "start": 168, "end": 199}, {"text": "pAI-1", "start": 201, "end": 206}]}}, "schema": []}
{"input": "These residues, Ile244 at the extracellular end of transmembrane helix 3, and Tyr318 at the COOH-terminal portion of extracellular loop 2, are replaced by Leu and Ile in the PTH-1 receptor, respectively.", "output": {"entities": {"gene": [{"text": "PTH-1 receptor", "start": 174, "end": 188}]}}, "schema": []}
{"input": "We have now shown that in vivo phosphorylation of 14-3-3 zeta at the CKIalpha site (Thr-233) negatively regulates its binding to c-Raf, and may be important in Raf-mediated signal transduction.", "output": {"entities": {"gene": [{"text": "14-3-3 zeta", "start": 50, "end": 61}, {"text": "CKIalpha site (Thr-233)", "start": 69, "end": 92}, {"text": "c-Raf", "start": 129, "end": 134}, {"text": "Raf", "start": 160, "end": 163}]}}, "schema": []}
{"input": "Mouse mast cell protease 9, a novel member of the chromosome 14 family of serine proteases that is selectively expressed in uterine mast cells.", "output": {"entities": {"gene": [{"text": "Mouse mast cell protease 9", "start": 0, "end": 26}, {"text": "serine proteases", "start": 74, "end": 90}]}}, "schema": []}
{"input": "A DNase I-hypersensitive site has also been mapped in the 258-base pair enhancer region.", "output": {"entities": {"gene": [{"text": "DNase I-hypersensitive site", "start": 2, "end": 29}]}}, "schema": []}
{"input": "Together, our results show that tinman is controlled by an array of discrete enhancer elements that are activated successively by differential genetic inputs, as well as by closely linked activator and repressor binding sites within an early-acting enhancer, which restrict twist activity to specific areas within the twist expression domain.", "output": {"entities": {"gene": [{"text": "tinman", "start": 32, "end": 38}, {"text": "twist", "start": 274, "end": 279}, {"text": "twist expression domain", "start": 318, "end": 341}]}}, "schema": []}
{"input": "The Fis protein regulates site-specific DNA inversion catalyzed by a family of DNA invertases when bound to a cis-acting recombinational enhancer.", "output": {"entities": {"gene": [{"text": "Fis protein", "start": 4, "end": 15}, {"text": "DNA invertases", "start": 79, "end": 93}]}}, "schema": []}
{"input": "The cell cycle-regulated transcription factor E2F is also known to bend DNA upon binding.", "output": {"entities": {"gene": [{"text": "E2F", "start": 46, "end": 49}]}}, "schema": []}
{"input": "Our study reveals that the modular structure of the FSH receptor gene generates motifs that allows coupling to different effectors.", "output": {"entities": {"gene": [{"text": "FSH receptor", "start": 52, "end": 64}]}}, "schema": []}
{"input": "Transcriptional regulation of SUP35 and SUP45 in Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "SUP35", "start": 30, "end": 35}, {"text": "SUP45 in Saccharomyces cerevisiae", "start": 40, "end": 73}]}}, "schema": []}
{"input": "These studies serve as the basis for the further characterization of the regulatory mechanism of aromatase expression in human breast cancer and ASCs.", "output": {"entities": {"gene": [{"text": "aromatase", "start": 97, "end": 106}]}}, "schema": []}
{"input": "Xenopus Ran-binding protein 1: molecular interactions and effects on nuclear assembly in Xenopus egg extracts.", "output": {"entities": {"gene": [{"text": "Xenopus Ran-binding protein 1", "start": 0, "end": 29}]}}, "schema": []}
{"input": "She improved with a combination of benzodiazepines and the acetylcholinesterase inhibitor physostigmine.", "output": {"entities": {"gene": [{"text": "acetylcholinesterase", "start": 59, "end": 79}]}}, "schema": []}
{"input": "METHODS: Total muscle paralysis was induced under general anesthesia in a group of obese persons (n = 9; body mass index, 32 +/-3 kg [-2]) and in a group of nonobese persons (n = 9; body mas index, 21 +/-2 kg [-2]).", "output": {"entities": {}}, "schema": []}
{"input": "PKA phosphorylated WT1 at Ser-365 and Ser-393 in vitro, as well as at additional sites, and this phosphorylation abolished the DNA-binding activity of WT1 in vitro.", "output": {"entities": {"gene": [{"text": "PKA", "start": 0, "end": 3}, {"text": "WT1", "start": 19, "end": 22}, {"text": "WT1", "start": 151, "end": 154}]}}, "schema": []}
{"input": "Our findings provide the first evidence that the function of WT1 can be modulated by its phosphorylation in vivo.", "output": {"entities": {"gene": [{"text": "WT1", "start": 61, "end": 64}]}}, "schema": []}
{"input": "A second aim was to determine whether the decrease in muscle-tendon unit rest length produced by prolonged immobilisation in a shortened position is mediated primarily by adaptations of the muscle or tendon.", "output": {"entities": {}}, "schema": []}
{"input": "The presence of an additional sequence of nucleotides 145-165 from the 3' end of RNA3 enhanced template recognition by RdRp in vitro and accumulation of RNA3 in vivo to wild-type levels.", "output": {"entities": {"gene": [{"text": "RNA3", "start": 81, "end": 85}, {"text": "RdRp", "start": 119, "end": 123}, {"text": "RNA3", "start": 153, "end": 157}]}}, "schema": []}
{"input": "We argue that the primary role of hh in controlling polarity is to cause anterior compartment cells to reverse their interpretation of an underlying symmetric polarization.", "output": {"entities": {"gene": [{"text": "hh", "start": 34, "end": 36}]}}, "schema": []}
{"input": "The results of this study suggest that NF-kappaB activity may be regulated by its interaction with the cell cycle regulatory protein, E2F-1.", "output": {"entities": {"gene": [{"text": "NF-kappaB", "start": 39, "end": 48}, {"text": "E2F-1", "start": 134, "end": 139}]}}, "schema": []}
{"input": "The lysozyme FEF site is immediately 5' to a PU.", "output": {"entities": {"gene": [{"text": "lysozyme FEF", "start": 4, "end": 16}, {"text": "PU", "start": 45, "end": 47}]}}, "schema": []}
{"input": "Osteocalcin (OC) is a matrix calcium-binding protein expressed in osteoblasts and odontoblasts undergoing mineralization.", "output": {"entities": {"gene": [{"text": "Osteocalcin", "start": 0, "end": 11}, {"text": "OC", "start": 13, "end": 15}, {"text": "matrix calcium-binding protein", "start": 22, "end": 52}]}}, "schema": []}
{"input": "In this study, we examine the effects of Msx2 expression on OC promoter activation (luciferase reporter) by FGF2/FSK and calcitriol in MC3T3-E1 osteoblasts.", "output": {"entities": {"gene": [{"text": "Msx2", "start": 41, "end": 45}, {"text": "OC promoter", "start": 60, "end": 71}, {"text": "luciferase reporter", "start": 84, "end": 103}, {"text": "FGF2", "start": 108, "end": 112}, {"text": "FSK", "start": 113, "end": 116}]}}, "schema": []}
{"input": "Thus, unlike other proteins reported to inhibit SRF activity, the repressor activity associated with the GC-rich element does not appear to function through direct inhibition of SRF binding.", "output": {"entities": {"gene": [{"text": "SRF", "start": 48, "end": 51}, {"text": "SRF", "start": 178, "end": 181}]}}, "schema": []}
{"input": "However, one CAK-phosphorylated phosphopeptide comigrates with a Cdc2-phosphorylated phosphopeptide previously shown to be mitosis-specific, suggesting that, in vitro, CAK is able to phosphorylate at least one site that is also phosphorylated in vivo.", "output": {"entities": {"gene": [{"text": "CAK", "start": 13, "end": 16}, {"text": "Cdc2", "start": 65, "end": 69}, {"text": "CAK", "start": 168, "end": 171}]}}, "schema": []}
{"input": "The pen can heal.", "output": {"entities": {}}, "schema": []}
{"input": "The mHIF-1 alpha structural gene is composed of 15 exons.", "output": {"entities": {"gene": [{"text": "mHIF-1 alpha structural gene", "start": 4, "end": 32}]}}, "schema": []}
{"input": "However, when a second, upstream IRE-like sequence was evaluated by EMSA, a DNA binding pattern distinct from that seen following exposure to IFN-gamma alone was observed after prolonged stimulation with both IFN-alpha and IFN-gamma.", "output": {"entities": {"gene": [{"text": "upstream IRE-like sequence", "start": 24, "end": 50}, {"text": "IFN-gamma", "start": 142, "end": 151}, {"text": "IFN-alpha", "start": 209, "end": 218}, {"text": "IFN-gamma", "start": 223, "end": 232}]}}, "schema": []}
{"input": "In Arabidopsis, the induction of a dehydration-responsive gene, rd22, is mediated by abscisic acid (ABA) and requires protein biosynthesis for ABA-dependent gene expression.", "output": {"entities": {"gene": [{"text": "rd22", "start": 64, "end": 68}]}}, "schema": []}
{"input": "A cDNA encoding a MYC-related DNA binding protein was isolated by DNA-ligand binding screening, using the 67-bp region as a probe, and designated rd22BP1.", "output": {"entities": {"gene": [{"text": "MYC-related DNA binding protein", "start": 18, "end": 49}, {"text": "rd22BP1", "start": 146, "end": 153}]}}, "schema": []}
{"input": "Human PDK1 is homologous to the Drosophila protein kinase DSTPK61, which has been implicated in the regulation of sex differentiation, oogenesis and spermatogenesis.", "output": {"entities": {"gene": [{"text": "Human PDK1", "start": 0, "end": 10}, {"text": "Drosophila protein kinase DSTPK61", "start": 32, "end": 65}]}}, "schema": []}
{"input": "Thus, the synergistic effects of HNF-1beta and the GR on dexamethasone-stimulated promoter activity require that they are bound to the HNF-1 site and the GRE, respectively, and may involve protein-protein interactions between the transcription factors, or between them and the basal transcription machinery or a steroid receptor coactivator.", "output": {"entities": {"gene": [{"text": "HNF-1beta", "start": 33, "end": 42}, {"text": "GR", "start": 51, "end": 53}, {"text": "HNF-1 site", "start": 135, "end": 145}, {"text": "steroid receptor coactivator", "start": 312, "end": 340}]}}, "schema": []}
{"input": "Mutational analysis shows that both an AP-1 like sequence (-294/-285, TGAATCATCA) and an A/T-rich myocyte enhancer factor (MEF)-2 like sequence (-310/-298, TTAAAAATAAAAA) in the 33-bp region are necessary for the OP-1 effect.", "output": {"entities": {"gene": [{"text": "AP-1 like sequence", "start": 39, "end": 57}, {"text": "myocyte enhancer factor (MEF)-2 like sequence", "start": 98, "end": 143}, {"text": "OP-1", "start": 213, "end": 217}]}}, "schema": []}
{"input": "Unlike most other members of the Bcl-2 family, BAD (Bcl-xL/Bcl-2 associated death promoter), a death enhancer, has no C-terminal transmembrane domain for targeting to the outer mitochondrial membrane and nuclear envelope.", "output": {"entities": {"gene": [{"text": "Bcl-2 family", "start": 33, "end": 45}, {"text": "BAD", "start": 47, "end": 50}, {"text": "Bcl-xL/Bcl-2 associated death promoter", "start": 52, "end": 90}, {"text": "death enhancer", "start": 95, "end": 109}]}}, "schema": []}
{"input": "An open reading frame of 2862 bp encoding a 954 amino acid protein was identified.", "output": {"entities": {}}, "schema": []}
{"input": "One of these, an AACA motif, has been shown to be a negative regulator in non-seed tissues and has a similarity to the barley gibberellin responsive element recognized by MYB-like DNA binding proteins.", "output": {"entities": {"gene": [{"text": "MYB-like DNA binding proteins", "start": 171, "end": 200}]}}, "schema": []}
{"input": "Strain CFN037 is an R. etli mutant induced by a single Tn5mob insertion in the promoter region of the thiCOGE gene cluster.", "output": {"entities": {"gene": [{"text": "Tn5mob", "start": 55, "end": 61}, {"text": "thiCOGE gene cluster", "start": 102, "end": 122}]}}, "schema": []}
{"input": "Expression of thiamin biosynthetic genes (thiCOGE) and production of symbiotic terminal oxidase cbb3 in Rhizobium etli.", "output": {"entities": {"gene": [{"text": "thiCOGE", "start": 42, "end": 49}, {"text": "symbiotic terminal oxidase cbb3", "start": 69, "end": 100}]}}, "schema": []}
{"input": "We have cloned and sequenced a region encoding a lipase operon and a putative, previously uncharacterized metalloprotease of Vibrio cholerae O1.", "output": {"entities": {"gene": [{"text": "lipase operon", "start": 49, "end": 62}, {"text": "metalloprotease of Vibrio cholerae O1", "start": 106, "end": 143}]}}, "schema": []}
{"input": "Furthermore, the amount of tRNA (3Lys) that was placed onto viral RNA in mutated viruses was significantly less than that placed in the wild-type virus.", "output": {"entities": {"gene": [{"text": "tRNA (3Lys)", "start": 27, "end": 38}]}}, "schema": []}
{"input": "This protein is present in both HeLa nuclear extracts and S100 extracts but absent from SR protein preparations, suggesting that it is not a classical SR protein.", "output": {"entities": {"gene": [{"text": "S100", "start": 58, "end": 62}, {"text": "SR protein", "start": 88, "end": 98}, {"text": "SR protein", "start": 151, "end": 161}]}}, "schema": []}
{"input": "Acad.", "output": {"entities": {}}, "schema": []}
{"input": "Chimeras containing IE1 peptides dramatically activated transcription of the basal promoter only when lac operator sequences were present.", "output": {"entities": {"gene": [{"text": "IE1 peptides", "start": 20, "end": 32}, {"text": "lac operator sequences", "start": 102, "end": 124}]}}, "schema": []}
{"input": "The results of replicase assays performed with mutant VP2 containing a deletion in its RNA-binding domain suggests that the essential role for VP2 in replication is linked to the protein' s ability to bind the mRNA template for minus-strand synthesis.", "output": {"entities": {"gene": [{"text": "replicase", "start": 15, "end": 24}, {"text": "mutant VP2", "start": 47, "end": 57}, {"text": "VP2", "start": 143, "end": 146}]}}, "schema": []}
{"input": "We previously described two alanine cluster mutations, R77 to A (R77A)-K79A and E192A-E194A, which selectively inactivated the triphosphatase component.", "output": {"entities": {}}, "schema": []}
{"input": "Transfection of HepG2 and SK-N-MC cells with constructs deleted of additional 5'-flanking fragments permitted the definition of a minimal 200 bp promoter fragment containing the pseudo-TATA box and two putative SP1-binding sites.", "output": {"entities": {"gene": [{"text": "SP1-binding sites", "start": 211, "end": 228}]}}, "schema": []}
{"input": "Both inserts are larger than their homologues in eIF-2alpha kinases.", "output": {"entities": {"gene": [{"text": "eIF-2alpha kinases", "start": 49, "end": 67}]}}, "schema": []}
{"input": "Three monopolar electrodes were inserted into the left and right lateral vestibulospinal tract (LVST) and medial vestibulospinal tract (MVST) of the C1 segment, to determine the pathway of axons.", "output": {"entities": {}}, "schema": []}
{"input": "Epitopes of adhesion-perturbing monoclonal antibodies map within a predicted alpha-helical domain of the integrin beta 1 subunit.", "output": {"entities": {"gene": [{"text": "integrin beta 1 subunit", "start": 105, "end": 128}]}}, "schema": []}
{"input": "Polyhomeotic and Posterior Sex Combs may participate in a more general transcriptional mechanism that causes modulated gene repression, whereas the inclusion of Polycomb protein in the complex at PREs leads to stable silencing.", "output": {"entities": {"gene": [{"text": "Polyhomeotic and Posterior Sex Combs", "start": 0, "end": 36}, {"text": "Polycomb protein", "start": 161, "end": 177}, {"text": "PREs", "start": 196, "end": 200}]}}, "schema": []}
{"input": "Furthermore, both rhHR23 proteins function in a defined NER system reconstituted with purified proteins, indicating direct involvement of hHR23 proteins in the DNA repair reaction via interaction with XPC.", "output": {"entities": {"gene": [{"text": "rhHR23 proteins", "start": 18, "end": 33}, {"text": "hHR23 proteins", "start": 138, "end": 152}, {"text": "XPC", "start": 201, "end": 204}]}}, "schema": []}
{"input": "The yeast silent information regulator Sir4p anchors and partitions plasmids.", "output": {"entities": {"gene": [{"text": "silent information regulator Sir4p", "start": 10, "end": 44}]}}, "schema": []}
{"input": "Polysome analyses in a temperature-sensitive fal1-1 mutant and a Fal1p-depleted strain reveal a decrease in the number of 40S ribosomal subunits.", "output": {"entities": {"gene": [{"text": "fal1-1 mutant", "start": 45, "end": 58}, {"text": "Fal1p", "start": 65, "end": 70}, {"text": "40S ribosomal subunits", "start": 122, "end": 144}]}}, "schema": []}
{"input": "Sequence analysis identified some of these cDNA clones as Dlc-1, a sequence encoding a small, 9-kDa human homolog of the outer-arm dynein light-chain protein.", "output": {"entities": {"gene": [{"text": "Dlc-1", "start": 58, "end": 63}, {"text": "9-kDa human homolog of the outer-arm dynein light-chain", "start": 94, "end": 149}]}}, "schema": []}
{"input": "Importantly, in HeLa and 293 cells, endogenous and transfected I kappaB alpha coimmunoprecipitated with Myc-tagged or endogenous Dlc-1.", "output": {"entities": {"gene": [{"text": "I kappaB alpha", "start": 63, "end": 77}, {"text": "Myc", "start": 104, "end": 107}, {"text": "Dlc-1", "start": 129, "end": 134}]}}, "schema": []}
{"input": "Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.", "output": {"entities": {"gene": [{"text": "dynein heavy chain genes", "start": 18, "end": 42}, {"text": "axonemal dynein gene", "start": 111, "end": 131}]}}, "schema": []}
{"input": "The proposed mechanism of effect states that mono (2-ethylhexyl) phthalate (MEHP), the primary hydrolysis product of DEHP, mimics the inducing prostaglandins (PG) PGD (2), 9alpha, 11betaPGF2, and PGF2alpha, and thromboxanes in the lungs, thereby increasing the risk of inducing inflammation in the airways, which is a characteristic of asthma.", "output": {"entities": {}}, "schema": []}
{"input": "We found 14 protein binding sites that were occupied in vivo.", "output": {"entities": {}}, "schema": []}
{"input": "Constitutive protection of E2F recognition sequences in the human thymidine kinase promoter during cell cycle progression.", "output": {"entities": {"gene": [{"text": "E2F recognition sequences", "start": 27, "end": 52}, {"text": "human thymidine kinase promoter", "start": 60, "end": 91}]}}, "schema": []}
{"input": "Comparison of genomic sequence shows that the ph locus has been duplicated, and that it contains proximal and distal transcription units.", "output": {"entities": {"gene": [{"text": "ph locus", "start": 46, "end": 54}]}}, "schema": []}
{"input": "Radiation decreased the levels of T4 and T3 6 h and 72 h in group C, in group A at 72 h, in group B at 24 h postexposure.", "output": {"entities": {}}, "schema": []}
{"input": "We have reviewed the experience of a major MMT general practice with hepatitis C virus (HCV) infection from 1991 to 1995.", "output": {"entities": {}}, "schema": []}
{"input": "The author analyzes extensive own data based on study into particular features of cardiovascular disorders in chronic renal impairement with making use of modern diagnostic tools.", "output": {"entities": {}}, "schema": []}
{"input": "In this paper, characterization is given of clinical and biochemical features of VH B course against the background of narcomania.", "output": {"entities": {}}, "schema": []}
{"input": "447 microns for A. microcephalum and 350 microns for A. wedli), and fewer testes per proglottis (44-73 vs.", "output": {"entities": {}}, "schema": []}
{"input": "The ZnF20 cDNA hybridized to multiple transcripts in a thyroid cancer cell line (8. 0, 4. 5 and 2 kb) that increased after cycloheximide treatment and decayed < 2 h after addition of actinomycin D.", "output": {"entities": {"gene": [{"text": "ZnF20 cDNA", "start": 4, "end": 14}]}}, "schema": []}
{"input": "Glutathione S-transferase (GST)-E2F and GST-DP fusion proteins were found to cooperate in binding to the three E2F sites in the DNA polymerase alpha gene promoter in vitro.", "output": {"entities": {"gene": [{"text": "Glutathione S-transferase", "start": 0, "end": 25}, {"text": "GST", "start": 27, "end": 30}, {"text": "E2F", "start": 32, "end": 35}, {"text": "GST", "start": 40, "end": 43}, {"text": "DP", "start": 44, "end": 46}, {"text": "E2F sites", "start": 111, "end": 120}, {"text": "DNA polymerase alpha gene promoter", "start": 128, "end": 162}]}}, "schema": []}
{"input": "Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol.", "output": {"entities": {"gene": [{"text": "caveolin gene", "start": 70, "end": 83}, {"text": "low density lipoprotein", "start": 113, "end": 136}]}}, "schema": []}
{"input": "Furthermore, DNA-bound LAZ3/BCL6 recruits SMRT in vivo, and both overexpressed proteins completely colocalize in nuclear dots.", "output": {"entities": {"gene": [{"text": "LAZ3", "start": 23, "end": 27}, {"text": "BCL6", "start": 28, "end": 32}, {"text": "SMRT", "start": 42, "end": 46}]}}, "schema": []}
{"input": "CONCLUSIONS: We obtained normal EPO levels for mothers and newborns for our area, similarly to the previously described ones.", "output": {"entities": {"gene": [{"text": "EPO", "start": 32, "end": 35}]}}, "schema": []}
{"input": "Ischaemia was induced by a low flow rate of 0. 8 mL min-1 for 30 min, and was followed by a 40-minute reperfusion.", "output": {"entities": {}}, "schema": []}
{"input": "BACKGROUND: Checkpoint pathways prevent cell-cycle progression in the event of DNA lesions.", "output": {"entities": {}}, "schema": []}
{"input": "Direct proof that the heightened renal cellular apoptosis in PKD is not occurring through p53 was obtained by successive matings between SBM and p53 (-/-) mice.", "output": {"entities": {"gene": [{"text": "p53", "start": 90, "end": 93}, {"text": "p53", "start": 145, "end": 148}]}}, "schema": []}
{"input": "Accumulated evidence indicates that, upon stimulation with interferon-gamma (IFN-gamma), three beta-type subunits, designated LMP2, LMP7, and PSMB10, are incorporated into the 20S proteasome by displacing the housekeeping beta-type subunits designated PSMB6, PSMB5, and PSMB7, respectively.", "output": {"entities": {"gene": [{"text": "interferon-gamma", "start": 59, "end": 75}, {"text": "IFN-gamma", "start": 77, "end": 86}, {"text": "LMP2", "start": 126, "end": 130}, {"text": "LMP7", "start": 132, "end": 136}, {"text": "PSMB10", "start": 142, "end": 148}, {"text": "20S proteasome", "start": 176, "end": 190}, {"text": "PSMB6", "start": 252, "end": 257}, {"text": "PSMB5", "start": 259, "end": 264}, {"text": "PSMB7", "start": 270, "end": 275}]}}, "schema": []}
{"input": "The major RNase E cleavage product (denoted pSok-6) is rapidly degraded by polynucleotide phosphorylase (PNPase).", "output": {"entities": {"gene": [{"text": "RNase E", "start": 10, "end": 17}, {"text": "pSok-6", "start": 44, "end": 50}, {"text": "polynucleotide phosphorylase", "start": 75, "end": 103}, {"text": "PNPase", "start": 105, "end": 111}]}}, "schema": []}
{"input": "This difference may result from the lower match to the ARG box consensus of the O (rocD) site.", "output": {"entities": {"gene": [{"text": "O (rocD) site", "start": 80, "end": 93}]}}, "schema": []}
{"input": "Ask AONE' s experts... about productivity indicators.", "output": {"entities": {}}, "schema": []}
{"input": "All pigs had significant regional LV dysfunction and reduced LV ejection fraction (41 +/-11%).", "output": {"entities": {}}, "schema": []}
{"input": "The progress of morphological research on the parabrachial nucleus", "output": {"entities": {}}, "schema": []}
{"input": "The amplitudes of DPOAE also recovered to a greater extent and outer hair cell losses were less severe in the R-PIA-treated ears.", "output": {"entities": {}}, "schema": []}
{"input": "The data provide evidence both for a signal transduction pathway independent of JNK, ERK, and p38 MAP kinase to be involved in the induction of rhoB by genotoxic stress, and furthermore, indicate autoregulation of rhoB.", "output": {"entities": {"gene": [{"text": "JNK", "start": 80, "end": 83}, {"text": "ERK", "start": 85, "end": 88}, {"text": "p38 MAP kinase", "start": 94, "end": 108}, {"text": "rhoB", "start": 144, "end": 148}, {"text": "rhoB", "start": 214, "end": 218}]}}, "schema": []}
{"input": "In an effort to separate domains of FadR required for DNA binding, dimerization, and ligand binding, chimeric protein fusions between the DNA binding domain of LexA and different regions of FadR were constructed.", "output": {"entities": {"gene": [{"text": "FadR", "start": 36, "end": 40}, {"text": "LexA", "start": 160, "end": 164}, {"text": "FadR", "start": 190, "end": 194}]}}, "schema": []}
{"input": "Inhibition appears to result from titration of general transcription factors because MDM2 overexpression inhibits c-fos as well as other promoters in vivo and basal transcription in vitro.", "output": {"entities": {"gene": [{"text": "MDM2", "start": 85, "end": 89}, {"text": "c-fos", "start": 114, "end": 119}]}}, "schema": []}
{"input": "4) PU and PD lacked the canonical TATA or CAAT motifs, and are AT-rich.", "output": {"entities": {"gene": [{"text": "PU", "start": 3, "end": 5}, {"text": "PD", "start": 10, "end": 12}]}}, "schema": []}
{"input": "The mobility shift of both of these proteins is abolished by treatment with inhibitors of PKC or mitogen-activated protein kinase/extracellular signal-related kinase kinase.", "output": {"entities": {"gene": [{"text": "PKC", "start": 90, "end": 93}, {"text": "mitogen-activated protein kinase", "start": 97, "end": 129}, {"text": "extracellular signal-related kinase kinase", "start": 130, "end": 172}]}}, "schema": []}
{"input": "During the aftermath of excitation of the skin sympathetic nerve by mental arithmetics, 3/12 A delta units were turned to the active state with decreased mechanical threshold.", "output": {"entities": {}}, "schema": []}
{"input": "In a similar fashion to adipose stromal cells, serum potentiated the response to dexamethasone but had no effect on phorbol ester-stimulated activity.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, Hex expression marks the earliest unequivocal molecular anteroposterior asymmetry in the mouse embryo and indicates that the anteroposterior axis of the embryo develops from conversion of a proximodistal asymmetry established in the primitive endoderm lineage.", "output": {"entities": {"gene": [{"text": "Hex", "start": 6, "end": 9}]}}, "schema": []}
{"input": "CONCLUSIONS: While INR correction may be achieved by all the above methods, that relating log reference INR to log local prothrombin time by linear regression analysis is the simplest to perform.", "output": {"entities": {"gene": [{"text": "prothrombin", "start": 121, "end": 132}]}}, "schema": []}
{"input": "RESULTS: The overall FNF for 1992 was 12. 3% and was 19. 1%, 22. 2%, 3. 8% and 6. 1% per successive quarters in 1992.", "output": {"entities": {}}, "schema": []}
{"input": "Western blot analysis of various bovine tissues with human NMT peptide antibody indicated a common prominent immunoreactive band with an apparent molecular mass of 48. 5-50 kDa in all tissues.", "output": {"entities": {"gene": [{"text": "NMT peptide antibody", "start": 59, "end": 79}]}}, "schema": []}
{"input": "Transcription start sites of the plastid ACCase genes were estimated from the longest cDNA clones obtained by 5'-RACE (rapid amplification of cDNA ends).", "output": {"entities": {"gene": [{"text": "ACCase genes", "start": 41, "end": 53}]}}, "schema": []}
{"input": "AIDS-related disseminated histoplasmosis in San Francisco, California.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, Fis acts as an accessory transcriptional activator at the mar promoter.", "output": {"entities": {"gene": [{"text": "Fis", "start": 6, "end": 9}, {"text": "mar promoter", "start": 64, "end": 76}]}}, "schema": []}
{"input": "TNF-alpha exposure markedly increased activity of several RNA-binding proteins, especially a novel Mr 50, 000-55, 000 RNA-binding protein.", "output": {"entities": {"gene": [{"text": "TNF-alpha", "start": 0, "end": 9}]}}, "schema": []}
{"input": "We speculate that the human papillomavirus late mRNAs, produced from several hundred copies of the virus genome present in infected cells, compete with the c-fos mRNAs for destabilizing cellular factors and that this may lead to elevated Fos protein levels in human papillomavirus infected cells.", "output": {"entities": {"gene": [{"text": "c-fos mRNAs", "start": 156, "end": 167}, {"text": "Fos protein", "start": 238, "end": 249}]}}, "schema": []}
{"input": "Two closely related IgH constant region genes, CHA and CHB, have been sequenced completely.", "output": {"entities": {"gene": [{"text": "IgH", "start": 20, "end": 23}, {"text": "CHA", "start": 47, "end": 50}, {"text": "CHB", "start": 55, "end": 58}]}}, "schema": []}
{"input": "The aim of this study was to find out whether it was possible to detect normal lymph nodes by high-resolution mediastinal US.", "output": {"entities": {}}, "schema": []}
{"input": "To study the role of heavy chain motifs in substrate recognition, secreted variants of recombinant bovine proenteropeptidase were constructed by replacing the transmembrane domain with a signal peptide.", "output": {"entities": {"gene": [{"text": "recombinant bovine proenteropeptidase", "start": 87, "end": 124}]}}, "schema": []}
{"input": "CKbeta4GT-II is predicted to encode a type II transmembrane glycoprotein of 43 kDa with five potential N-linked glycosylation sites.", "output": {"entities": {"gene": [{"text": "CKbeta4GT-II", "start": 0, "end": 12}, {"text": "type II transmembrane glycoprotein", "start": 38, "end": 72}]}}, "schema": []}
{"input": "PATIENTS AND METHODS: Semen analyses were performed on 58 patients with stages I-III HD before, during, and after chemotherapy and after the sperm count recovered from the effects of abdominal radiotherapy that was given after chemotherapy.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, the absence of residual infarct-zone viability discriminates patients who develop progressive left ventricular dilation after reperfused AMI from those who maintain normal left ventricular geometry.", "output": {"entities": {}}, "schema": []}
{"input": "With a BMI cutoff of 27, mean cardiac NE spillover was 46% lower in the obese subjects when compared with the lean subjects (P =. 017).", "output": {"entities": {}}, "schema": []}
{"input": "The gene (ApxII) encoding both chloroplastic ascorbate peroxidase isoenzymes was isolated and the organization of the gene was determined.", "output": {"entities": {"gene": [{"text": "ApxII", "start": 10, "end": 15}, {"text": "chloroplastic ascorbate peroxidase isoenzymes", "start": 31, "end": 76}]}}, "schema": []}
{"input": "This emphasizes the conclusion that CDF-1 is not an E2F family member and points to profound differences in the cell cycle regulation of CDF-1 and E2F.", "output": {"entities": {"gene": [{"text": "CDF-1", "start": 36, "end": 41}, {"text": "E2F family member", "start": 52, "end": 69}, {"text": "CDF-1", "start": 137, "end": 142}, {"text": "E2F", "start": 147, "end": 150}]}}, "schema": []}
{"input": "The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains.", "output": {"entities": {"gene": [{"text": "Escherichia coli DNA polymerase I", "start": 27, "end": 60}, {"text": "DNA and/or RNA exonuclease domains", "start": 71, "end": 105}]}}, "schema": []}
{"input": "Responsibility matters--this is a scientific council", "output": {"entities": {}}, "schema": []}
{"input": "Sequences required for interaction of mu2 and CTLA-4 were localized to residues, 161TTGVY in CTLA-4; this sequence is N-terminal to, but overlaps with, a previously identified SH2 binding motif, 165YVKM, involved in CTLA-4 signaling.", "output": {"entities": {"gene": [{"text": "mu2", "start": 38, "end": 41}, {"text": "CTLA-4", "start": 46, "end": 52}, {"text": "CTLA-4", "start": 93, "end": 99}, {"text": "SH2 binding motif", "start": 176, "end": 193}, {"text": "CTLA-4", "start": 216, "end": 222}]}}, "schema": []}
{"input": "Here, we report that a transfected Chinese hamster ovary (CHO) cell line expressing a murine CD4 fragment containing the first two N-terminal domains secretes both monomeric molecules and disulfide-linked multimers.", "output": {"entities": {"gene": [{"text": "murine CD4 fragment", "start": 86, "end": 105}]}}, "schema": []}
{"input": "Coexpression of mouse PKR (1-515) WT as a Gal4 DNA-binding domain fusion with either the catalytic-deficient human PKR (1-551) K296R mutant, the RNA-binding-deficient human PKR (1-551) K64E/K296R double mutant, or wild-type mouse PKR (1-515) WT as full-length PKR-Gal4 activation domain fusions resulted in activation of the HIS3 and lacZ reporters.", "output": {"entities": {"gene": [{"text": "PKR (1-515) WT", "start": 22, "end": 36}, {"text": "Gal4", "start": 42, "end": 46}, {"text": "PKR (1-551)", "start": 115, "end": 126}, {"text": "PKR (1-551) K64E/K296R", "start": 173, "end": 195}, {"text": "PKR (1-515) WT", "start": 230, "end": 244}, {"text": "PKR", "start": 260, "end": 263}, {"text": "Gal4", "start": 264, "end": 268}, {"text": "HIS3", "start": 325, "end": 329}, {"text": "lacZ", "start": 334, "end": 338}]}}, "schema": []}
{"input": "Using GST-PKR fusion chromatography, direct physical interaction between the mouse and human PKR homologs was established.", "output": {"entities": {"gene": [{"text": "GST", "start": 6, "end": 9}, {"text": "PKR", "start": 10, "end": 13}, {"text": "human PKR homologs", "start": 87, "end": 105}]}}, "schema": []}
{"input": "An even greater inflammatory response was observed after intratracheal instillation of ufCB, but not after CB instillation.", "output": {"entities": {}}, "schema": []}
{"input": "Interestingly, the avirulent strain H37Ra showed weak hybridization with these two probes, suggesting that these genes might have been deleted in the avirulent strain or are present in limited copy numbers as opposed to those in the virulent strain H37Rv.", "output": {"entities": {}}, "schema": []}
{"input": "These defects no doubt impair the folding and configuration necessary for normal processing of the AVP gene precursor.", "output": {"entities": {"gene": [{"text": "AVP gene precursor", "start": 99, "end": 117}]}}, "schema": []}
{"input": "Similarities between the hIGFBP-1 and phosphoenolpyruvate kinase (PEPCK) promoters, including regions conferring insulin, glucocorticoid, and cyclic adenosine-monophosphate responses, are consistent with our previous hypothesis that IGFBP-1 is involved in regulation of glucose metabolism.", "output": {"entities": {"gene": [{"text": "hIGFBP-1", "start": 25, "end": 33}, {"text": "phosphoenolpyruvate kinase", "start": 38, "end": 64}, {"text": "PEPCK", "start": 66, "end": 71}, {"text": "insulin", "start": 113, "end": 120}, {"text": "IGFBP-1", "start": 233, "end": 240}]}}, "schema": []}
{"input": "This binary repeat contains repetitive DNA elements that include LINES, SINES, medium reiteration frequency repeats, and a transposon-like element.", "output": {"entities": {}}, "schema": []}
{"input": "At 60 days the amount of gangliosides was on average lower in females than in males, even if with some exception.", "output": {"entities": {}}, "schema": []}
{"input": "Large genomic constructs integrate at the endogenous locus by homologous recombination, but cDNA-derived sequences lacking long stretches of contiguous genomic DNA (due to intron excision) typically integrate into chromosomal DNA by nonhomologous recombination.", "output": {"entities": {}}, "schema": []}
{"input": "During the conditioning procedure, the C-fiber reflex was facilitated (wind-up) in a stimulus-dependent fashion in intact, anesthetized animals during the application of the first seven conditioning stimuli; thereafter, the magnitude of the responses reached a plateau and then decreased.", "output": {"entities": {}}, "schema": []}
{"input": "As a sequence-specific DNA binding transcription factor, p53 specifically binds to a 20-bp consensus motif 5'-PuPuPuC (A/T) (T/A) GPyPyPyPuPuPuC (A/T) (T/A) GPyPyPy-3'.", "output": {"entities": {"gene": [{"text": "p53", "start": 57, "end": 60}]}}, "schema": []}
{"input": "Upon UV damage, Crb2 is transiently modified, probably phosphorylated, with a similar timing of phosphorylation in Chk1 kinase, which is reported to restrain Cdc2 activation.", "output": {"entities": {"gene": [{"text": "Crb2", "start": 16, "end": 20}, {"text": "Chk1 kinase", "start": 115, "end": 126}, {"text": "Cdc2", "start": 158, "end": 162}]}}, "schema": []}
{"input": "Moreover, moderate overexpression of Chk1 suppresses the phenotypes of cut5 and crb2 mutants.", "output": {"entities": {"gene": [{"text": "Chk1", "start": 37, "end": 41}, {"text": "cut5", "start": 71, "end": 75}, {"text": "crb2 mutants", "start": 80, "end": 92}]}}, "schema": []}
{"input": "Tcn1p/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression in Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "Tcn1p", "start": 0, "end": 5}, {"text": "Crz1p", "start": 6, "end": 11}]}}, "schema": []}
{"input": "Structure and localization of the human gene encoding SR-BI/CLA-1.", "output": {"entities": {"gene": [{"text": "SR-BI", "start": 54, "end": 59}, {"text": "CLA-1", "start": 60, "end": 65}]}}, "schema": []}
{"input": "We introduced the gel technique as a routine assay for antibody detection and identification in 1993.", "output": {"entities": {}}, "schema": []}
{"input": "Stability of pyrimethamine in a liquid dosage formulation stored for three months.", "output": {"entities": {}}, "schema": []}
{"input": "Multiple regression analyses revealed that WAIS-R factor scores Verbal Comprehension and Freedom from Distractibility accounted for up to 42% of the variance in WMS-R and CVLT indices.", "output": {"entities": {}}, "schema": []}
{"input": "Bilateral basal arteries were measured by the transtemporal approach with a 2 MHz pulsed Doppler instrument (TC-2 64B EME).", "output": {"entities": {}}, "schema": []}
{"input": "At the genomic level, the sequences of two members of this family are known in the rat Rattus norvegicus: the VCSA1 gene, encoding the prohormone-like polypeptide SMR1, and the VCSB1 gene, encoding a salivary Pro-rich polypeptide.", "output": {"entities": {"gene": [{"text": "VCSA1 gene", "start": 110, "end": 120}, {"text": "prohormone-like polypeptide SMR1", "start": 135, "end": 167}, {"text": "VCSB1 gene", "start": 177, "end": 187}]}}, "schema": []}
{"input": "The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanism.", "output": {"entities": {"gene": [{"text": "Saccharomyces cerevisiae RAD30 gene", "start": 4, "end": 39}, {"text": "homologue of Escherichia coli dinB", "start": 43, "end": 77}, {"text": "umuC", "start": 82, "end": 86}]}}, "schema": []}
{"input": "However, in a new experiment in which the deletion task was presented as a puppet game, and with pretraining and selection on vowel deletion, a significantly higher level of success was achieved by the children working with the CVCC material.", "output": {"entities": {}}, "schema": []}
{"input": "Diet therapy with soy proteins for chronic stomach ulcers", "output": {"entities": {}}, "schema": []}
{"input": "In ICU patients, the LIS related to the postoperative rise in IL-6 level only, even though the rise in plasma concentrations of cytokines interrelated.", "output": {"entities": {"gene": [{"text": "IL-6", "start": 62, "end": 66}]}}, "schema": []}
{"input": "Resistance training shifts the power curve in a positive direction when the measurements are determined with absolute loads, but the increased power may not be transferred to an absolute performance task like the SSP.", "output": {"entities": {}}, "schema": []}
{"input": "Gel-shift assays identified two Sp1 binding sites within this element.", "output": {"entities": {"gene": [{"text": "Sp1 binding sites", "start": 32, "end": 49}]}}, "schema": []}
{"input": "Gel mobility shift and super-shift assays using liver nuclear extracts from either rat liver or DDT1MF-2 cells demonstrated that the CRE in the alpha 1B-AR gene bound CRE binding protein.", "output": {"entities": {"gene": [{"text": "alpha 1B-AR gene", "start": 144, "end": 160}, {"text": "CRE binding protein", "start": 167, "end": 186}]}}, "schema": []}
{"input": "These results suggest that, in this experimental model, ACE inhibitors limit the arrhythmias following ischemia-reperfusion and free radical scavenging action of these drugs does not have a major contributory role in their protective effect.", "output": {"entities": {"gene": [{"text": "ACE", "start": 56, "end": 59}]}}, "schema": []}
{"input": "The murine Htf9-a/RanBP1 and Htf9-c genes are divergently transcribed from a shared TATA-less promoter.", "output": {"entities": {"gene": [{"text": "Htf9-a", "start": 11, "end": 17}, {"text": "RanBP1", "start": 18, "end": 24}, {"text": "Htf9-c genes", "start": 29, "end": 41}]}}, "schema": []}
{"input": "In accordance with clinical improvement we found a decrease of laboratory indicators of inflammation (C-reactive protein, alpha 2-globuline, prostaglandin E2).", "output": {"entities": {"gene": [{"text": "C-reactive protein", "start": 102, "end": 120}, {"text": "alpha 2-globuline", "start": 122, "end": 139}]}}, "schema": []}
{"input": "We have previously reported that depletion of protein kinase C by long-term treatment of B16 mouse melanoma cells with phorbol dibutyrate (PDBu) prevented cell density-dependent melanogenesis.", "output": {"entities": {"gene": [{"text": "protein kinase C", "start": 46, "end": 62}]}}, "schema": []}
{"input": "Replacement of residues in positions + 3 (His128Asn) and + 2 (Gln155Lys) of the reading helices of fingers 2 and 3, respectively, prevented binding.", "output": {"entities": {}}, "schema": []}
{"input": "Two disulphide bridges, which are conserved in all spermadhesin molecules and many CUB domains, crosslink loop LA and strand beta 4 and loops LE and LG, respectively, at opposite edges of the same face of the domain.", "output": {"entities": {}}, "schema": []}
{"input": "Mg-chelatase of tobacco: identification of a Chl D cDNA sequence encoding a third subunit, analysis of the interaction of the three subunits with the yeast two-hybrid system, and reconstitution of the enzyme activity by co-expression of recombinant CHL D, CHL H and CHL I.", "output": {"entities": {"gene": [{"text": "Mg-chelatase", "start": 0, "end": 12}, {"text": "Chl D cDNA sequence", "start": 45, "end": 64}, {"text": "recombinant CHL D", "start": 237, "end": 254}, {"text": "CHL H", "start": 256, "end": 261}, {"text": "CHL I", "start": 266, "end": 271}]}}, "schema": []}
{"input": "One R-EST and one Pto-like sequence each mapped to two locations.", "output": {"entities": {"gene": [{"text": "Pto-like sequence", "start": 18, "end": 35}]}}, "schema": []}
{"input": "The multidomain structure includes a cysteine-rich motif resembling those of protein kinase C and n-chimaerin and a putative pleckstrin homology domain.", "output": {"entities": {"gene": [{"text": "protein kinase C", "start": 77, "end": 93}, {"text": "n-chimaerin", "start": 98, "end": 109}, {"text": "pleckstrin homology domain", "start": 125, "end": 151}]}}, "schema": []}
{"input": "271: 31290-31295, 1996).", "output": {"entities": {}}, "schema": []}
{"input": "Nevertheless, antibodies directed against an epitope-tagged version of Prp42p specifically precipitate U1 snRNA from yeast extracts.", "output": {"entities": {"gene": [{"text": "Prp42p", "start": 71, "end": 77}, {"text": "U1 snRNA", "start": 103, "end": 111}]}}, "schema": []}
{"input": "These results indicate that in addition to Grb2-mediated activation of Ras, PLC-gamma1-mediated DAG production is required for EGF-and PDGF-induced S-phase entry and gene expression, possibly through activation of PKC.", "output": {"entities": {"gene": [{"text": "Grb2", "start": 43, "end": 47}, {"text": "Ras", "start": 71, "end": 74}, {"text": "PLC-gamma1", "start": 76, "end": 86}, {"text": "EGF", "start": 127, "end": 130}, {"text": "PDGF", "start": 135, "end": 139}, {"text": "PKC", "start": 214, "end": 217}]}}, "schema": []}
{"input": "In this study, we investigated STAT activation in a panel of rodent fibroblast cell lines stably transformed by diverse viral oncoproteins.", "output": {"entities": {"gene": [{"text": "STAT", "start": 31, "end": 35}]}}, "schema": []}
{"input": "In serum-stimulated cells, the binding of NF-Y/CBF to TKC1 increased gradually, reaching a plateau at the S phase.", "output": {"entities": {"gene": [{"text": "NF-Y", "start": 42, "end": 46}, {"text": "CBF", "start": 47, "end": 50}, {"text": "TKC1", "start": 54, "end": 58}]}}, "schema": []}
{"input": "CONCLUSION: In our animal model, blood-brain barrier disruption was a reproducible, integral finding of single-fraction, high-dose irradiation injury.", "output": {"entities": {}}, "schema": []}
{"input": "To facilitate the investigation of parameters that govern selective export in adenovirus-infected cells, we constructed a marked human beta-actin minigene under the control of the glucocorticoid-inducible enhancer-promoter of mouse mammary tumor virus and introduced it into the left end of the adenovirus type 5 (Ad5) genome.", "output": {"entities": {"gene": [{"text": "beta-actin minigene", "start": 135, "end": 154}, {"text": "glucocorticoid-inducible enhancer-promoter", "start": 180, "end": 222}]}}, "schema": []}
{"input": "Cell factor-mediated regulatory interactions are involved in regulating the restricted expression of the HCMV major immediate-early (IE) gene (J.", "output": {"entities": {"gene": [{"text": "HCMV major immediate-early (IE) gene", "start": 105, "end": 141}]}}, "schema": []}
{"input": "MpB GroEL has extensive sequence similarity (92%) with Escherichia coli GroEL and other members of the chaperonin-60 family.", "output": {"entities": {"gene": [{"text": "MpB GroEL", "start": 0, "end": 9}, {"text": "Escherichia coli GroEL", "start": 55, "end": 77}, {"text": "chaperonin-60 family", "start": 103, "end": 123}]}}, "schema": []}
{"input": "The critical mutations were likely to have been multiple and dispersed, including elongation of the TM and Nef coding sequences; changes in RNA splice donor and acceptor sites, TATA box sites, and Sp1 sites; multiple changes in the V2 region of SU, including a consensus neutralization epitope; and five new N-linked glycosylation sites in SU.", "output": {"entities": {"gene": [{"text": "Nef coding sequences", "start": 107, "end": 127}, {"text": "Sp1 sites", "start": 197, "end": 206}, {"text": "V2", "start": 232, "end": 234}, {"text": "SU", "start": 245, "end": 247}, {"text": "SU", "start": 340, "end": 342}]}}, "schema": []}
{"input": "C.", "output": {"entities": {}}, "schema": []}
{"input": "These are the long terminal repeat (LTR) promoter, which regulates expression of the viral structural proteins, and a second internal promoter, located towards the 3' end of the env gene, that directs expression of the viral auxiliary proteins.", "output": {"entities": {"gene": [{"text": "env gene", "start": 178, "end": 186}]}}, "schema": []}
{"input": "The 5' end of the genomic RNA of rubella virus (RUB) contains a 14-nucleotide (nt) single-stranded leader (ss-leader) followed by a stem-and-loop structure [5' (+) SL] (nt 15 to 65), the complement of which at the 3' end of the minus-strand RNA [3' (-) SL] has been proposed to function as a promoter for synthesis of genomic plus strands.", "output": {"entities": {}}, "schema": []}
{"input": "To investigate the requirements for CBF2 binding, we synthesized a series of oligonucleotides carrying double transversion mutations spanning both the conserved core sequence and outside flanking sequences.", "output": {"entities": {"gene": [{"text": "CBF2", "start": 36, "end": 40}]}}, "schema": []}
{"input": "In addition, the affinities of CBF2 for binding to the LMP-1, LMP-2, and CD23 promoters were also measured.", "output": {"entities": {"gene": [{"text": "CBF2", "start": 31, "end": 35}, {"text": "LMP-1", "start": 55, "end": 60}, {"text": "LMP-2", "start": 62, "end": 67}, {"text": "CD23 promoters", "start": 73, "end": 87}]}}, "schema": []}
{"input": "CONCLUSIONS: The myocardial uptake of 99mTc sestamibi in normal subjects and patients with coronary artery disease is comparable after exercise, dipyridamole, and adenosine stress.", "output": {"entities": {}}, "schema": []}
{"input": "The SR protein family is involved in constitutive and regulated pre-mRNA splicing and has been found to be evolutionarily conserved in metazoan organisms.", "output": {"entities": {"gene": [{"text": "SR protein family", "start": 4, "end": 21}]}}, "schema": []}
{"input": "To investigate the activity of TCF11 through this selected site, both alone and in the presence of MafG, we have used a transient transfection assay.", "output": {"entities": {"gene": [{"text": "TCF11", "start": 31, "end": 36}, {"text": "MafG", "start": 99, "end": 103}]}}, "schema": []}
{"input": "These and other comparisons suggest that, during evolution, both the RNA-polymerase specificity of telomerase RNA-gene promoters and, more recently, the position of the template sequence in the telomerase RNA changed.", "output": {"entities": {"gene": [{"text": "RNA-polymerase", "start": 69, "end": 83}, {"text": "telomerase RNA-gene promoters", "start": 99, "end": 128}, {"text": "telomerase RNA", "start": 194, "end": 208}]}}, "schema": []}
{"input": "Deadenylation and decay of beta-globin mRNA in K562 cells is extraordinarily slow compared with NIH 3T3 cells, suggesting that the increased stability gained by beta-globin mRNA in K562 cells is mainly controlled at the deadenylation step.", "output": {"entities": {"gene": [{"text": "beta-globin mRNA", "start": 27, "end": 43}, {"text": "beta-globin mRNA", "start": 161, "end": 177}]}}, "schema": []}
{"input": "Holliday junction resolvase in Schizosaccharomyces pombe has identical endonuclease activity to the CCE1 homologue YDC2.", "output": {"entities": {"gene": [{"text": "Holliday junction resolvase", "start": 0, "end": 27}, {"text": "CCE1", "start": 100, "end": 104}, {"text": "YDC2", "start": 115, "end": 119}]}}, "schema": []}
{"input": "Ca2 +/calmodulin-dependent protein kinase II (CaMK II) is a multifunctional serine/threonine protein kinase that regulates ion channels, metabolic enzymes, cytoskeletal proteins, and possibly transcription factors.", "output": {"entities": {"gene": [{"text": "Ca2 +/calmodulin-dependent protein kinase II", "start": 0, "end": 44}, {"text": "CaMK II", "start": 46, "end": 53}, {"text": "serine/threonine protein kinase", "start": 76, "end": 107}]}}, "schema": []}
{"input": "A cAMP-responsive element-like (CRE-like, TGACGTGA) promoter sequence and a protein kinase A signaling pathway are involved in this induction, and activation of both CRE binding protein (CREB) and activating transcription factor-2 (ATF-2) is required in the above process.", "output": {"entities": {"gene": [{"text": "protein kinase A", "start": 76, "end": 92}, {"text": "CRE binding protein", "start": 166, "end": 185}, {"text": "CREB", "start": 187, "end": 191}, {"text": "activating transcription factor-2", "start": 197, "end": 230}, {"text": "ATF-2", "start": 232, "end": 237}]}}, "schema": []}
{"input": "IVOX was named as an acronym for intravascular oxygenator.", "output": {"entities": {}}, "schema": []}
{"input": "Histopathologically, a cystic lymphangioma was diagnosed because of the morphological features and the immunohistochemical stainings of CD34 and Factor VIII related antigen which were observed positive reactions in endothelial cells of the cysts.", "output": {"entities": {"gene": [{"text": "CD34", "start": 136, "end": 140}, {"text": "Factor VIII related antigen", "start": 145, "end": 172}]}}, "schema": []}
{"input": "Protease activities in cultures of the streptococcal strains were associated with species of different molecular masses ranging from 130 to 200 kDa, suggesting posttranslational processing possibly as a result of autoproteolysis at post-proline peptide bonds in the N-terminal parts of the molecules.", "output": {"entities": {}}, "schema": []}
{"input": "The mechanism underlying such analgesia has been suggested to involve the interaction between the two separate but interconnected motivational systems \" defense \" and \" pain. \" To determine the developmental course of defense and nociception, these processes were analyzed during early ontogeny in rats.", "output": {"entities": {}}, "schema": []}
{"input": "Three large field placement errors (two patients with 11. 5 and 16. 0 mm distances of the planned versus simulated isocenter, respectively and one patient with a 7 degree rotational error) were detected and, as with the smaller errors, were immediately corrected.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, a catalytically inactive version of the Src family member, Lck (lymphoid cell kinase), was expressed, purified, and evaluated as a Csk substrate.", "output": {"entities": {"gene": [{"text": "Src family", "start": 53, "end": 63}, {"text": "Lck", "start": 72, "end": 75}, {"text": "lymphoid cell kinase", "start": 77, "end": 97}, {"text": "Csk", "start": 144, "end": 147}]}}, "schema": []}
{"input": "A., Swift, A.", "output": {"entities": {}}, "schema": []}
{"input": "Neuronal mechanisms underlying stimulus-response (S-R) associations in S-R compatibility tasks were identified in 2 experiments with monkeys.", "output": {"entities": {}}, "schema": []}
{"input": "The c-myc/TGF-alpha HCCs were also characterized by a particularly strong expression of TGF-alpha and very low apoptotic index in contrast to high levels of apoptosis in peritumorous tissues and c-myc HCCs.", "output": {"entities": {"gene": [{"text": "c-myc", "start": 4, "end": 9}, {"text": "TGF-alpha", "start": 10, "end": 19}, {"text": "TGF-alpha", "start": 88, "end": 97}, {"text": "c-myc", "start": 195, "end": 200}]}}, "schema": []}
{"input": "Taken together, our data suggest that the antagonistic effects of CRP and KdgR on the expression of the pectinolysis genes occur by different mechanisms, including direct competition between the two regulators or between the repressor and RNA polymerase for the occupation of a common DNA region on the target genes.", "output": {"entities": {"gene": [{"text": "CRP", "start": 66, "end": 69}, {"text": "KdgR", "start": 74, "end": 78}, {"text": "pectinolysis genes", "start": 104, "end": 122}, {"text": "RNA polymerase", "start": 239, "end": 253}]}}, "schema": []}
{"input": "The well-known Rel/NF-kappaB family of vertebrate transcription factors comprises a number of structurally related, interacting proteins that bind DNA as dimers and whose activity is regulated by subcellular location.", "output": {"entities": {"gene": [{"text": "Rel", "start": 15, "end": 18}, {"text": "NF-kappaB", "start": 19, "end": 28}]}}, "schema": []}
{"input": "The cglIM gene is organized in an unusual operon which contains, in addition, two genes encoding stress-sensitive restriction enzymes.", "output": {"entities": {"gene": [{"text": "cglIM gene", "start": 4, "end": 14}]}}, "schema": []}
{"input": "The purpose of this investigation was to describe a new formulation of silver sulfadiazine in a water soluble gel, poloxamer 188.", "output": {"entities": {}}, "schema": []}
{"input": "The study goals were to isolate a full-length clone encoding CO-Ag from a bovine corneal cDNA library and to express this clone in Escherichia coli (E. coli).", "output": {"entities": {"gene": [{"text": "CO-Ag", "start": 61, "end": 66}]}}, "schema": []}
{"input": "The gene contains six exons separated by 1. 1-5. 8 kb introns and has been localized to the murine chromosome 2 by linkage analysis.", "output": {"entities": {}}, "schema": []}
{"input": "In Xenopus embryos, the engineered PDGF receptor protein induced the formation of mesoderm from animal-pole explants in an FK1012-dependent manner.", "output": {"entities": {"gene": [{"text": "engineered PDGF receptor protein", "start": 24, "end": 56}]}}, "schema": []}
{"input": "A cytosolic variant of the protein underwent efficient transphosphorylation, yet failed to activate appreciably either p70 (S6k) or MAP kinase following treatment with FK1012.", "output": {"entities": {"gene": [{"text": "p70", "start": 119, "end": 122}, {"text": "S6k", "start": 124, "end": 127}, {"text": "MAP kinase", "start": 132, "end": 142}]}}, "schema": []}
{"input": "Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment.", "output": {"entities": {"gene": [{"text": "insulin", "start": 26, "end": 33}, {"text": "PDGF receptor", "start": 38, "end": 51}]}}, "schema": []}
{"input": "Conversely, the inactive dAK subunit is progressively activated by 1) association with a dGK or dCK subunit and 2) the conformationally driven heterotropic affect of dGuo or dCyd bound to the opposing subunit.", "output": {"entities": {"gene": [{"text": "dAK subunit", "start": 25, "end": 36}, {"text": "dGK", "start": 89, "end": 92}, {"text": "dCK subunit", "start": 96, "end": 107}, {"text": "dGuo", "start": 166, "end": 170}, {"text": "dCyd", "start": 174, "end": 178}]}}, "schema": []}
{"input": "CONCLUSIONS: A 50-mg daily dose of bicalutamide is sufficient when given in combination with an agent, such as a LHRH-A, that lowers serum testosterone, but higher doses of bicalutamide may be needed when the drug is given as monotherapy.", "output": {"entities": {"gene": [{"text": "LHRH", "start": 113, "end": 117}]}}, "schema": []}
{"input": "A genomic clone was isolated that contained 12. 5 kb of the 5'-flanking region and the first exon of the p69/71 2-5A synthetase gene.", "output": {"entities": {"gene": [{"text": "p69/71 2-5A synthetase gene", "start": 105, "end": 132}]}}, "schema": []}
{"input": "Although the gene is substantially smaller than the human genes for other mitochondrial enzymes, its intron/exon organization is very similar, especially to that of P450scc.", "output": {"entities": {"gene": [{"text": "P450scc", "start": 165, "end": 172}]}}, "schema": []}
{"input": "RESULTS: Looking at the question of its benefits, we were unable to find any methodologically sound studies that have shown efficacy for EMDR in eating disorders, or, indeed, any psychiatric disorder.", "output": {"entities": {}}, "schema": []}
{"input": "Transient overexpression of mutant EphB1 receptors (Y594F) blocked Nck recruitment to EphB1, attenuated downstream JNK activation, and blocked cell attachment responses.", "output": {"entities": {"gene": [{"text": "mutant EphB1 receptors", "start": 28, "end": 50}, {"text": "Nck", "start": 67, "end": 70}, {"text": "EphB1", "start": 86, "end": 91}, {"text": "JNK", "start": 115, "end": 118}]}}, "schema": []}
{"input": "S., and Walter, P.", "output": {"entities": {}}, "schema": []}
{"input": "Here we demonstrate that Hh and Patched (Ptc) act through those Ci binding sites to modulate the level of Ci-dependent transcriptional activation in S2 cells.", "output": {"entities": {"gene": [{"text": "Hh", "start": 25, "end": 27}, {"text": "Patched", "start": 32, "end": 39}, {"text": "Ptc", "start": 41, "end": 44}, {"text": "Ci", "start": 64, "end": 66}, {"text": "Ci", "start": 106, "end": 108}]}}, "schema": []}
{"input": "Furthermore the median increase in cyclosporine DR/C (SS trough) was 18 l h-1 (-3. 1 to 42. 1 l h-1, interquartile range).", "output": {"entities": {}}, "schema": []}
{"input": "Patients and their relatives must be informed about the available effective treatment possibilities and about the right moment for their application in an individual patient.", "output": {"entities": {}}, "schema": []}
{"input": "Several PTPases were expressed abundantly in the 5-FU-treated bone marrow stem cells.", "output": {"entities": {"gene": [{"text": "PTPases", "start": 8, "end": 15}]}}, "schema": []}
{"input": "Expression of PTPRO was also observed in human CD34 + bone marrow cells and 5-FU-treated murine primitive stem cells.", "output": {"entities": {"gene": [{"text": "PTPRO", "start": 14, "end": 19}, {"text": "human CD34 +", "start": 41, "end": 53}]}}, "schema": []}
{"input": "The organization of SPP1 genes involved in the replication, DNA packaging and phage assembly proteins resembles the organization of genes of equivalent regions of different E. coli double-stranded DNA phages.", "output": {"entities": {"gene": [{"text": "SPP1 genes", "start": 20, "end": 30}]}}, "schema": []}
{"input": "Our results showed that compared to the primary photon fluence, the extra-focal photon fluence from the primary collimator and the flattening filter was 11%-16% at the isocenter, among which 70% was contributed by the flattening filter.", "output": {"entities": {}}, "schema": []}
{"input": "The functional mature domain of pediocin AcH (Lys + 1 to Cys + 44) is targeted into the E. coli sec machinery and secreted to the periplasm in active form when fused in frame to the COOH terminus of the secretory protein maltose-binding protein (MBP).", "output": {"entities": {"gene": [{"text": "pediocin AcH (Lys + 1 to Cys + 44)", "start": 32, "end": 66}, {"text": "secretory protein maltose-binding protein", "start": 203, "end": 244}, {"text": "MBP", "start": 246, "end": 249}]}}, "schema": []}
{"input": "Isomers were differentiated based on the MS-MS data of the trofluoroacetyl-biphenylol derivatives.", "output": {"entities": {}}, "schema": []}
{"input": "Clinical value of the estimation of growth kinetics of primary ovarian cancer recurrences by CA125 doubling time", "output": {"entities": {"gene": [{"text": "CA125", "start": 93, "end": 98}]}}, "schema": []}
{"input": "This review seeks to summarize the disease, to propose pathways of carcinogenesis and to suggest ways in which the \" traditional \" risk factors may be interpreted on the basis of evolving knowledge.", "output": {"entities": {}}, "schema": []}
{"input": "The patient underwent two intracytoplasmic sperm injection cycles with thawed epididymal spermatozoa, in which, due to a pharmacist' s mistake, ovarian stimulation was carried out by a combination of long-acting gonadotrophin-releasing hormone agonist (leuprolide depot) and gonadotrophins.", "output": {"entities": {"gene": [{"text": "gonadotrophin-releasing hormone", "start": 212, "end": 243}, {"text": "gonadotrophins", "start": 275, "end": 289}]}}, "schema": []}
{"input": "Perhaps in addition to, or as part of, its essential function in late mitosis, MOB1 is required for a cell cycle reset function necessary for the initiation of the spindle pole body duplication.", "output": {"entities": {"gene": [{"text": "MOB1", "start": 79, "end": 83}]}}, "schema": []}
{"input": "In contrast, overproduction of Der3p is lethal in a sec61-2 strain at the permissive temperature of 25 degrees C.", "output": {"entities": {"gene": [{"text": "Der3p", "start": 31, "end": 36}, {"text": "sec61-2", "start": 52, "end": 59}]}}, "schema": []}
{"input": "Normal baseline (day-8) PC levels (86 and 89%) were markedly reduced in both patients at the time of VOD manifestation on day 20 and 40, respectively (26 and 31%).", "output": {"entities": {}}, "schema": []}
{"input": "To examine the role of this CE2 element in regulating Hoxa1 expression in vivo, transgenic mice were generated which express a Hoxa1 beta-galactosidase reporter gene that contains a mutation in the CE2 element.", "output": {"entities": {"gene": [{"text": "Hoxa1", "start": 54, "end": 59}, {"text": "Hoxa1 beta-galactosidase", "start": 127, "end": 151}]}}, "schema": []}
{"input": "An evolutionary conserved element is essential for somite and adjacent mesenchymal expression of the Hoxa1 gene.", "output": {"entities": {"gene": [{"text": "Hoxa1 gene", "start": 101, "end": 111}]}}, "schema": []}
{"input": "RESULTS: The bovine cDNA insert sequence was 273 nucleotides in length for the entire mRNA coding region, 212 nucleotides in the 5' untranslated region, 83 nucleotides in the 3' untranslated region and a poly (A) tail.", "output": {"entities": {}}, "schema": []}
{"input": "Altogether 46 phase III activities were recorded.", "output": {"entities": {}}, "schema": []}
{"input": "We have previously identified a liver-enriched transcription factor, HNF-6, which is required for HNF-3 beta promoter activity and also recognizes the regulatory region of numerous hepatocyte-specific genes.", "output": {"entities": {"gene": [{"text": "HNF-6", "start": 69, "end": 74}, {"text": "HNF-3 beta promoter", "start": 98, "end": 117}]}}, "schema": []}
{"input": "A cDNA clone was identified encoding a second GHS-R-related gene (GPR39).", "output": {"entities": {"gene": [{"text": "GHS-R-related gene", "start": 46, "end": 64}, {"text": "GPR39", "start": 66, "end": 71}]}}, "schema": []}
{"input": "(1997) Science 275, 1927-1930).", "output": {"entities": {}}, "schema": []}
{"input": "P., Peyron, J.", "output": {"entities": {}}, "schema": []}
{"input": "A hybridoma clone (7H1) resulting from the fusion between CEMLAI/NP and human embryonic fibroblasts MRC5 cells produced very large amounts of P47 that was purified using Jacalin lectin (specific for O-glycans) and microsequenced.", "output": {"entities": {"gene": [{"text": "P47", "start": 142, "end": 145}, {"text": "Jacalin lectin", "start": 170, "end": 184}]}}, "schema": []}
{"input": "This information, together with estimation of the size of the deglycosylated A subunit relative to a series of C-terminal truncated TSHR ectodomain variants, places cleavage Site 1 in the vicinity of, or closely upstream to, residue 317.", "output": {"entities": {"gene": [{"text": "C-terminal truncated TSHR ectodomain variants", "start": 111, "end": 156}]}}, "schema": []}
{"input": "In vitro DNase I footprinting of the 200-bp proximal region of the promoter with a murine Hepa 1-6 cell nuclear extract revealed a clear footprint of a region corresponding to-80 to-28 bp of the murine fVII gene, suggesting that liver factors interact with this region of the DNA.", "output": {"entities": {"gene": [{"text": "DNase I", "start": 9, "end": 16}, {"text": "murine fVII gene", "start": 195, "end": 211}]}}, "schema": []}
{"input": "Both increasing basal FSH and age were associated significantly with increased total gonadotrophin dose, and reduced number of oocytes collected and pregnancy rate.", "output": {"entities": {"gene": [{"text": "FSH", "start": 22, "end": 25}, {"text": "gonadotrophin", "start": 85, "end": 98}]}}, "schema": []}
{"input": "A comparative study was undertaken between an enzymatic immunohistochemical technique (EIT) developed for the diagnosis of human trichinellosis and the indirect immunofluorescence test (IIF), analysing sera from outbreaks of human trichinellosis in Argentina.", "output": {"entities": {}}, "schema": []}
{"input": "Our results establish GKLF as a sequence-specific transcription factor likely involved in regulation of expression of endogenous genes.", "output": {"entities": {"gene": [{"text": "GKLF", "start": 22, "end": 26}]}}, "schema": []}
{"input": "CES4 on a multicopy plasmid was unable to suppress tif1-A79V.", "output": {"entities": {"gene": [{"text": "CES4", "start": 0, "end": 4}, {"text": "tif1-A79V", "start": 51, "end": 60}]}}, "schema": []}
{"input": "Here we report that in cultured cells from Drosophila melanogaster human Sp1 efficiently activates transcription from synthetic promoters containing TATA boxes, but not from promoters that contain an initiator instead of a TATA box.", "output": {"entities": {"gene": [{"text": "human Sp1", "start": 67, "end": 76}]}}, "schema": []}
{"input": "No apparent clinical signs indicative of systemic toxicity were observed in the F0 and F1 animals of either sex.", "output": {"entities": {}}, "schema": []}
{"input": "In an effort to identify the USH1C disease gene we have isolated the region between these markers in yeast artificial chromosomes (YACs) using a combination of STS content mapping and Alu-PCR hybridization.", "output": {"entities": {"gene": [{"text": "USH1C disease gene", "start": 29, "end": 47}, {"text": "Alu", "start": 184, "end": 187}]}}, "schema": []}
{"input": "PowerBLAST analysis identified six clusters of expressed sequence tags (ESTs), two known genes (BIR, SUR1) mapped previously to this region, and a previously characterized but unmapped gene NEFA (DNA binding/EF hand/acidic amino-acid-rich).", "output": {"entities": {"gene": [{"text": "BIR", "start": 96, "end": 99}, {"text": "SUR1", "start": 101, "end": 105}, {"text": "gene NEFA", "start": 185, "end": 194}, {"text": "DNA binding/EF hand/acidic amino-acid-rich", "start": 196, "end": 238}]}}, "schema": []}
{"input": "A fusion protein composed of beta-galactosidase and full-length Ahr translocates from the cytoplasm to the nucleus in a ligand-dependent manner.", "output": {"entities": {"gene": [{"text": "beta-galactosidase", "start": 29, "end": 47}, {"text": "full-length Ahr", "start": 52, "end": 67}]}}, "schema": []}
{"input": "Reconstitution of Raf-1 activity was observed only with kinase active Jak1 in both cell lines.", "output": {"entities": {"gene": [{"text": "Raf-1", "start": 18, "end": 23}, {"text": "Jak1", "start": 70, "end": 74}]}}, "schema": []}
{"input": "In addition, negatively regulatory region may exist from-1782 to-1295 bp.", "output": {"entities": {}}, "schema": []}
{"input": "The hypothesis of Geisler (Brain Res.", "output": {"entities": {}}, "schema": []}
{"input": "The second transcript, rhis4l, is bicistronic.", "output": {"entities": {"gene": [{"text": "rhis4l", "start": 23, "end": 29}]}}, "schema": []}
{"input": "Consistent with this interpretation, a mutant form of XRN1, which encodes a 5'-3' exonuclease, was identified as an extragenic suppressor that increases the half-life of rhis4 mRNA, leading to a 10-fold increase in steady-state mRNA levels compared to the wild-type HIS4 mRNA level.", "output": {"entities": {"gene": [{"text": "XRN1", "start": 54, "end": 58}, {"text": "rhis4 mRNA", "start": 170, "end": 180}, {"text": "wild-type HIS4 mRNA", "start": 256, "end": 275}]}}, "schema": []}
{"input": "Sip1 was initially identified by virtue of its interaction with SC35, a splicing factor of the SR family.", "output": {"entities": {"gene": [{"text": "Sip1", "start": 0, "end": 4}, {"text": "SC35", "start": 64, "end": 68}, {"text": "SR family", "start": 95, "end": 104}]}}, "schema": []}
{"input": "Such mutations are thought to exert their dominant phenotype by sequestration of the guanine nucleotide exchange factor (GNEF).", "output": {"entities": {"gene": [{"text": "guanine nucleotide exchange factor", "start": 85, "end": 119}, {"text": "GNEF", "start": 121, "end": 125}]}}, "schema": []}
{"input": "Several studies have characterized the upstream regulatory region of c-fos, and identified cis-acting elements termed the cyclic AMP (cAMP) response elements (CREs) that are critical for c-fos transcription in response to a variety of extracellular stimuli.", "output": {"entities": {"gene": [{"text": "c-fos", "start": 69, "end": 74}, {"text": "c-fos", "start": 187, "end": 192}]}}, "schema": []}
{"input": "We have cloned a kinase, Nlk, that is a murine homolog of the Drosophila nemo (nmo) gene.", "output": {"entities": {"gene": [{"text": "Nlk", "start": 25, "end": 28}, {"text": "murine homolog of the Drosophila nemo", "start": 40, "end": 77}, {"text": "nmo", "start": 79, "end": 82}]}}, "schema": []}
{"input": "Our findings suggest that striatal FDG and particularly RACLO are sensitive and effective measures of striatal function and may help characterizing patients with multiple system atrophy.", "output": {"entities": {}}, "schema": []}
{"input": "Childhood misbehavior and the risk of injecting drug use.", "output": {"entities": {}}, "schema": []}
{"input": "Genetic analysis has subsequently identified subpathways of the DNA structure checkpoints, including the reversible arrest of DNA synthesis.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, Esigma54 promoters are responsive to CRP, a protein unrelated to sigma54 activators, and the repression exerted is the direct result of an interaction between Esigma54 and the CRP-cAMP complex.", "output": {"entities": {"gene": [{"text": "Esigma54 promoters", "start": 6, "end": 24}, {"text": "CRP", "start": 43, "end": 46}, {"text": "sigma54 activators", "start": 71, "end": 89}, {"text": "Esigma54", "start": 165, "end": 173}, {"text": "CRP-cAMP complex", "start": 182, "end": 198}]}}, "schema": []}
{"input": "GlcNAc-and GlcNAc2-PP-Dolichol biosynthesis could be shown with isolated S. cerevisiae membranes from cells harboring the recombinant plasmid and grown on glucose thus suppressing transcription of the endogenous gene.", "output": {"entities": {}}, "schema": []}
{"input": "Antibodies raised against GST mSH2-B identified a cellular protein of 92 kDa that was not found to be phosphorylated on Tyr.", "output": {"entities": {"gene": [{"text": "GST mSH2-B", "start": 26, "end": 36}]}}, "schema": []}
{"input": "Interleukin-6 (IL-6) is a pleiotropic cytokine, which is involved in inflammatory and immune responses, acute phase reactions, and hematopoiesis.", "output": {"entities": {"gene": [{"text": "Interleukin-6", "start": 0, "end": 13}, {"text": "IL-6", "start": 15, "end": 19}]}}, "schema": []}
{"input": "Upon analysis of various deletion and point-mutated variants of the human IL-6 gene promoter coupled to a reporter gene, we screened for possible cooperating transcription factors.", "output": {"entities": {"gene": [{"text": "human IL-6 gene promoter", "start": 68, "end": 92}]}}, "schema": []}
{"input": "This region, however, contains a CCAATC box in the reverse complement and several GC boxes that are recognition sites for SP1.", "output": {"entities": {"gene": [{"text": "SP1", "start": 122, "end": 125}]}}, "schema": []}
{"input": "Our purpose was to determine if intact perianal (S4-5) pin sensation (PPS) and bulbocavernosus (S2-4) reflex (BCR) shortly after spinal cord injury (SCI) are predictive of bladder function recovery.", "output": {"entities": {}}, "schema": []}
{"input": "The correct termination of retroviral transcripts at the 3' LTR R/U5 junction is primarily dependent on the canonical AAUAAA polyadenylation signal, so we have analyzed the effect of mutating the polyadenylation signal sequences on the properties of a selectable murine retroviral vector.", "output": {"entities": {}}, "schema": []}
{"input": "ALT levels in responders were lowered by 46% and AST levels were lowered by 35% after 12 weeks of vitamin E treatment.", "output": {"entities": {"gene": [{"text": "ALT", "start": 0, "end": 3}, {"text": "AST", "start": 49, "end": 52}]}}, "schema": []}
{"input": "51. 9% (P = 0. 0006) in the MMF versus the AZA groups, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Our study was designed to investigate the effect of MMF on in vivo bone mineral metabolism.", "output": {"entities": {}}, "schema": []}
{"input": "Pao2 increased from 15. 5 +/-5. 6 kPa (116 +/-42 mm Hg) to 17. 3 +/-6. 3 kPa (130 +/-47 mm Hg) (P < 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "Typical configurations of psychosocial stress factors of psychiatrically conspicuous children and adolescents", "output": {"entities": {}}, "schema": []}
{"input": "Nine cats received PMEA at a dosage of 10 mg/kg body weight, nine cats received FPMPA at a dosage of 25 mg/kg body weight.", "output": {"entities": {}}, "schema": []}
{"input": "Resistance to thyroid hormone: implications for neurodevelopmental research on the effects of thyroid hormone disruptors.", "output": {"entities": {}}, "schema": []}
{"input": "We present the preliminary results obtained on 36 patients which were followed for a mean period of 12 months.", "output": {"entities": {}}, "schema": []}
{"input": "Moreover, xTAK1KN could block the expression of ventral mesoderm marker genes induced by Smad1 or 5.", "output": {"entities": {"gene": [{"text": "xTAK1KN", "start": 10, "end": 17}, {"text": "Smad1 or 5", "start": 89, "end": 99}]}}, "schema": []}
{"input": "The assay exhibits a dynamic range of 0. 1-100 micrograms l-1 using a monoclonal antibody or alternatively 10 micrograms l-1 to 10 mg l-1 using commercially available antiserum.", "output": {"entities": {}}, "schema": []}
{"input": "A canonical TATA box was not detected.", "output": {"entities": {}}, "schema": []}
{"input": "Expression and characterization of recombinant single-chain Fv and Fv fragments derived from a set of catalytic antibodies.", "output": {"entities": {"gene": [{"text": "recombinant single-chain Fv", "start": 35, "end": 62}, {"text": "Fv fragments", "start": 67, "end": 79}]}}, "schema": []}
{"input": "A putative inhibitor (s) appears to co-elute in the inactive fraction that blocked the L (alpha) activity.", "output": {"entities": {"gene": [{"text": "L (alpha)", "start": 87, "end": 96}]}}, "schema": []}
{"input": "Platelet aggregation in response to 10 micrograms collagen/ml was decreased in parallel after treatment with ASA.", "output": {"entities": {"gene": [{"text": "collagen", "start": 50, "end": 58}]}}, "schema": []}
{"input": "Using himA mutants, we confirmed that IHF plays a role in the molybdate-dependent regulation of dmsA-lacZ expression in vivo.", "output": {"entities": {"gene": [{"text": "himA mutants", "start": 6, "end": 18}, {"text": "IHF", "start": 38, "end": 41}, {"text": "dmsA", "start": 96, "end": 100}, {"text": "lacZ", "start": 101, "end": 105}]}}, "schema": []}
{"input": "Cross-talking among Drosophila nuclear receptors at the promiscuous response element of the ng-1 and ng-2 intermolt genes.", "output": {"entities": {"gene": [{"text": "ng-1", "start": 92, "end": 96}, {"text": "ng-2 intermolt genes", "start": 101, "end": 121}]}}, "schema": []}
{"input": "The ipsilateral breast tumor relapse rate was similar between the PALP and MGDET groups.", "output": {"entities": {}}, "schema": []}
{"input": "Sibling aggregation of low-and high-density lipoprotein cholesterol and apolipoproteins B and A-I levels in black and white children: the Bogalusa Heart Study.", "output": {"entities": {"gene": [{"text": "low-and high-density lipoprotein cholesterol", "start": 23, "end": 67}, {"text": "apolipoproteins B and A-I", "start": 72, "end": 97}]}}, "schema": []}
{"input": "The CAPLC1 protein also exhibited several unique features, including a novel stretch of 18-19 amino acid residues within the X domain and an unusually long N-terminus which did not contain a recognizable EF-hand Ca (2 +)-binding domain.", "output": {"entities": {"gene": [{"text": "CAPLC1 protein", "start": 4, "end": 18}]}}, "schema": []}
{"input": "This hypothesis is consistent with the occurrence of PEA3 binding sites in the PEA3 promoter and with the ability of PEA3 to transactivate this promoter.", "output": {"entities": {"gene": [{"text": "PEA3 binding sites", "start": 53, "end": 71}, {"text": "PEA3 promoter", "start": 79, "end": 92}, {"text": "PEA3", "start": 117, "end": 121}]}}, "schema": []}
{"input": "Pet-1 can bind specifically to a PEA3 ETS DNA-binding motif and can modulate transcription of synthetic promoter constructs in a sequence-specific manner.", "output": {"entities": {"gene": [{"text": "Pet-1", "start": 0, "end": 5}, {"text": "PEA3 ETS", "start": 33, "end": 41}]}}, "schema": []}
{"input": "The protein expressed by F2771 cDNA in transfected COS cells is localized in the cytoplasm.", "output": {"entities": {"gene": [{"text": "F2771 cDNA", "start": 25, "end": 35}]}}, "schema": []}
{"input": "Northern analysis indicated differential expression by tissue with highest expression in the heart.", "output": {"entities": {}}, "schema": []}
{"input": "As well, further deletion of the promoter region to nucleotide-110, which contains only one SF-1 binding site, still retained the ability to respond to exogenous SF-1.", "output": {"entities": {"gene": [{"text": "SF-1 binding site", "start": 92, "end": 109}, {"text": "SF-1", "start": 162, "end": 166}]}}, "schema": []}
{"input": "The observation that beta 2m with covalently attached peptide can effectively create CTL target structures in vitro offers new possibilities for the in vivo induction of epitope-specific CTL responses by either DNA immunization or injection of the purified epitope-linked beta 2m.", "output": {"entities": {"gene": [{"text": "beta 2m", "start": 21, "end": 28}, {"text": "beta 2m", "start": 272, "end": 279}]}}, "schema": []}
{"input": "The mRNAs of these genes contain respectively one (YAP1 uORF) and two (YAP2 uORF1 and uORF2) upstream open reading frames. uORF-mediated modulation of post-termination events on the 5'-untranslated region (5'-UTR) directs differential control not only of translation but also of mRNA decay.", "output": {"entities": {"gene": [{"text": "YAP1 uORF", "start": 51, "end": 60}, {"text": "YAP2 uORF1", "start": 71, "end": 81}]}}, "schema": []}
{"input": "To further investigate the nature of the site specificity a set of deletion mutants of the 160 bp sequence were analysed.", "output": {"entities": {}}, "schema": []}
{"input": "In the tissues tested, except brain, the message for CLIP-170 was more abundant than that for Restin.", "output": {"entities": {"gene": [{"text": "CLIP-170", "start": 53, "end": 61}, {"text": "Restin", "start": 94, "end": 100}]}}, "schema": []}
{"input": "BACKGROUND: Chemicals vary considerably in their intrinsic ability to cause allergic contact dermatitis.", "output": {"entities": {}}, "schema": []}
{"input": "Also, the deduced amino acids of the antigenic regions A, B and C of VP7 were nearly conserved within the phylogenetic lineages.", "output": {"entities": {"gene": [{"text": "antigenic regions A, B and C of VP7", "start": 37, "end": 72}]}}, "schema": []}
{"input": "The cloned alcR gene provided in trans restored these siderophore system activities to the mutants.", "output": {"entities": {"gene": [{"text": "alcR gene", "start": 11, "end": 20}]}}, "schema": []}
{"input": "The cloned alcR gene provided in trans restored these siderophore system activities to the mutants.", "output": {"entities": {"gene": [{"text": "alcR gene", "start": 11, "end": 20}]}}, "schema": []}
{"input": "Copyright 1998 Academic Press.", "output": {"entities": {}}, "schema": []}
{"input": "It may also be suggested that particular care should be taken when such a trans-dominant Rev mutant is considered to be used as a genetic therapy against HIV-I infection, in individuals infected with both HIV-I and HTLV-1.", "output": {"entities": {"gene": [{"text": "Rev mutant", "start": 89, "end": 99}]}}, "schema": []}
{"input": "PATIENTS AND METHODS: Between January 1992 and June 1994 at St.", "output": {"entities": {}}, "schema": []}
{"input": "The frequency of SPs for both the moderate and severe groups was significantly higher than that in patients with a normal MMFCV (p <. 01); of 154 arms with a normal MMFCV, only 9 (6%) had an SP.", "output": {"entities": {}}, "schema": []}
{"input": "We analyzed the P-SAECG in the time and frequency domain in 23 patients with Paf and 19 controls.", "output": {"entities": {}}, "schema": []}
{"input": "Competitive reverse transcription-polymerase chain reaction and HPLC analysis showed that RUSH-1alpha is the progesterone-dependent splice variant.", "output": {"entities": {"gene": [{"text": "RUSH-1alpha", "start": 90, "end": 101}]}}, "schema": []}
{"input": "TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "TOR2", "start": 0, "end": 4}]}}, "schema": []}
{"input": "Transcervical amnioinfusion.", "output": {"entities": {}}, "schema": []}
{"input": "SETTING: A division of a large tea plantation in Kandy.", "output": {"entities": {}}, "schema": []}
{"input": "Simple models of bimolecular interaction did not fully account for the kinetic profiles obtained with the parental antibodies and the hybrids, and this complexity suggested the existence of a conformational heterogeneity in these molecules.", "output": {"entities": {}}, "schema": []}
{"input": "In order to decipher the pathway that leads to Hox gene induction, we have investigated whether a Hox gene regulator, the leucine zipper transcription factor MafB/Kr, is itself transcriptionally regulated by the environmental signals.", "output": {"entities": {"gene": [{"text": "Hox gene", "start": 47, "end": 55}, {"text": "Hox gene", "start": 98, "end": 106}, {"text": "MafB", "start": 158, "end": 162}, {"text": "Kr", "start": 163, "end": 165}]}}, "schema": []}
{"input": "Reporter constructs function in a parallel manner, demonstrating the key role of the AhR in constitutive as well as TCDD-induced expression of Cyp1B1 in mouse embryo fibroblasts.", "output": {"entities": {"gene": [{"text": "AhR", "start": 85, "end": 88}, {"text": "Cyp1B1", "start": 143, "end": 149}]}}, "schema": []}
{"input": "Transfection studies also showed that 3'-deletion of sequences downstream of the transcriptional start site (+ 1/+ 47) markedly reduced OSM-fold induction.", "output": {"entities": {"gene": [{"text": "OSM", "start": 136, "end": 139}]}}, "schema": []}
{"input": "Oncostatin M stimulates c-Fos to bind a transcriptionally responsive AP-1 element within the tissue inhibitor of metalloproteinase-1 promoter.", "output": {"entities": {"gene": [{"text": "Oncostatin M", "start": 0, "end": 12}, {"text": "c-Fos", "start": 24, "end": 29}, {"text": "AP-1 element", "start": 69, "end": 81}, {"text": "tissue inhibitor of metalloproteinase-1 promoter", "start": 93, "end": 141}]}}, "schema": []}
{"input": "We have isolated a new human RING-finger gene (RNF4) that encodes a 190-amino-acid protein.", "output": {"entities": {"gene": [{"text": "human RING-finger gene", "start": 23, "end": 45}, {"text": "RNF4", "start": 47, "end": 51}]}}, "schema": []}
{"input": "To elucidate the regulatory mechanism of human AM gene expression, functional elements of 5'-flanking region of AM gene were studied in human aortic endothelial cells (HAEC).", "output": {"entities": {"gene": [{"text": "human AM gene", "start": 41, "end": 54}, {"text": "AM gene", "start": 112, "end": 119}]}}, "schema": []}
{"input": "Soluble FasR ligand-binding domain: high-yield production of active fusion and non-fusion recombinant proteins using the baculovirus/insect cell system.", "output": {"entities": {"gene": [{"text": "FasR", "start": 8, "end": 12}]}}, "schema": []}
{"input": "The inhibition of focus formation observed in the presence of C3G was not due to toxic effects on cell viability, since transfected C3G cells exhibited the same survival and growth rates as untransfected NIH3T3 cells or cells transfected with plasmid vector alone.", "output": {"entities": {"gene": [{"text": "C3G", "start": 62, "end": 65}, {"text": "C3G", "start": 132, "end": 135}]}}, "schema": []}
{"input": "C. D2-Chr 4 congenic strains harboring DBA/2 alleles associated with the Pctr1 locus contained DBA/2 \" resistant \" alleles of the CDK4/CDK6 inhibitors p16 and p15.", "output": {"entities": {"gene": [{"text": "Pctr1 locus", "start": 73, "end": 84}, {"text": "CDK4", "start": 130, "end": 134}, {"text": "CDK6", "start": 135, "end": 139}, {"text": "p16", "start": 151, "end": 154}, {"text": "p15", "start": 159, "end": 162}]}}, "schema": []}
{"input": "When tested with wild-type (DBA/2) p16, both A134C and G232A BALB/c-specific variants of p16 were inefficient in their ability to inhibit the activity of cyclin D2/CDK4 in kinase assays with retinoblastoma protein, suggesting this defective, inherited allele plays an important role in the genetic susceptibility of BALB/c mice for plasmacytoma induction and that p16 (INK4a) is a strong candidate for the Pctr1 locus.", "output": {"entities": {"gene": [{"text": "p16", "start": 35, "end": 38}, {"text": "p16", "start": 89, "end": 92}, {"text": "cyclin D2", "start": 154, "end": 163}, {"text": "CDK4", "start": 164, "end": 168}, {"text": "retinoblastoma protein", "start": 191, "end": 213}, {"text": "p16", "start": 364, "end": 367}, {"text": "INK4a", "start": 369, "end": 374}, {"text": "Pctr1 locus", "start": 406, "end": 417}]}}, "schema": []}
{"input": "Despite this there was no difference in the intubating conditions at one minute with 25 excellent/5 good in the suxamethonium group and 27 excellent/3 good in the rocuronium group.", "output": {"entities": {}}, "schema": []}
{"input": "Cloning and expression of two genes encoding auxin-binding proteins from tobacco.", "output": {"entities": {"gene": [{"text": "auxin-binding proteins", "start": 45, "end": 67}]}}, "schema": []}
{"input": "Furthermore, direct association with D3 phosphatidylinositides seems to be essential for activation of PKB/Akt.", "output": {"entities": {"gene": [{"text": "PKB", "start": 103, "end": 106}, {"text": "Akt", "start": 107, "end": 110}]}}, "schema": []}
{"input": "The FMN moiety but not the [3Fe-4S] cluster of the subunit appears to participate in this reaction.", "output": {"entities": {}}, "schema": []}
{"input": "Alison Bell Memorial Award.", "output": {"entities": {}}, "schema": []}
{"input": "METHODS: A population survey was undertaken in 10, 148 individuals to measure the prevalence and identify the causes of blindness in Lebanon.", "output": {"entities": {}}, "schema": []}
{"input": "The mean duration of pain relief was 4-6 weeks.", "output": {"entities": {}}, "schema": []}
{"input": "The ESEM differs from conventional SEM in that no sample preparation is needed, eliminating artifactual changes.", "output": {"entities": {}}, "schema": []}
{"input": "The 3' fragment was shown to accumulate as full-length mRNA disappeared in actinomycin D-treated cells, indicating a precursor-product relationship.", "output": {"entities": {}}, "schema": []}
{"input": "The TATA box-binding protein (TBP) plays an essential role in transcription by all three eukaryotic nuclear RNA polymerases, polymerases (Pol) I, II, and III.", "output": {"entities": {"gene": [{"text": "TATA box-binding protein", "start": 4, "end": 28}, {"text": "TBP", "start": 30, "end": 33}, {"text": "nuclear RNA polymerases", "start": 100, "end": 123}, {"text": "polymerases (Pol) I, II, and III", "start": 125, "end": 157}]}}, "schema": []}
{"input": "A triple-mutant TBP (R231E + R235E + R239S) had greatly reduced activity for yeast U6 snRNA gene transcription while remaining active for Pol II basal transcription.", "output": {"entities": {"gene": [{"text": "triple-mutant TBP", "start": 2, "end": 19}, {"text": "yeast U6 snRNA gene", "start": 77, "end": 96}, {"text": "Pol II", "start": 138, "end": 144}]}}, "schema": []}
{"input": "E2F activity is regulated in part by the retinoblastoma family of tumor suppressor proteins.", "output": {"entities": {"gene": [{"text": "E2F", "start": 0, "end": 3}, {"text": "retinoblastoma family of tumor suppressor proteins", "start": 41, "end": 91}]}}, "schema": []}
{"input": "This resulted in a complete inhibition of Site-1 cleavage that was restored by concomitant overexpression of full-length SCAP.", "output": {"entities": {"gene": [{"text": "SCAP", "start": 121, "end": 125}]}}, "schema": []}
{"input": "To determine the true molecular identity of SFD, both the 50-and 57-kDa polypeptides were directly sequenced.", "output": {"entities": {"gene": [{"text": "SFD", "start": 44, "end": 47}]}}, "schema": []}
{"input": "Molecular characterization of the 50-and 57-kDa subunits of the bovine vacuolar proton pump.", "output": {"entities": {"gene": [{"text": "bovine vacuolar proton pump", "start": 64, "end": 91}]}}, "schema": []}
{"input": "In C. albicans, HST6 is expressed constitutively at high levels in the different cell types analysed (yeast, hyphae, white and opaque), demonstrating that HST6 transcription is not repressed in this diploid yeast, unlike in diploid S. cerevisiae, and suggesting a basic biological function for the Hst6p transporter in C. albicans.", "output": {"entities": {"gene": [{"text": "HST6", "start": 16, "end": 20}, {"text": "HST6", "start": 155, "end": 159}, {"text": "Hst6p", "start": 298, "end": 303}]}}, "schema": []}
{"input": "Furthermore, binding of recombinant Myb and Ets-2 protein to these fragments could be competed with an excess of double stranded oligodeoxynucleotides containing canonical, but not mutated, Myb-or Ets-binding sites.", "output": {"entities": {"gene": [{"text": "recombinant Myb", "start": 24, "end": 39}, {"text": "Ets-2 protein", "start": 44, "end": 57}, {"text": "Myb", "start": 190, "end": 193}, {"text": "Ets-binding sites", "start": 197, "end": 214}]}}, "schema": []}
{"input": "This structure interconnects specific triplets of the basal bodies with the microtubular bundles that emerge from the basal apparatus.", "output": {"entities": {}}, "schema": []}
{"input": "To understand the regulatory mechanism controlling its expression at low temperature, the promoter region has been characterized.", "output": {"entities": {}}, "schema": []}
{"input": "In the current study, the roles of two putative cis-acting elements within the-73 to + 44 region in basal exon 2 promoter activity were evaluated using mutagenesis and nuclear protein-DNA binding assays.", "output": {"entities": {}}, "schema": []}
{"input": "We have examined reporter gene (beta-gal) expression directed by human heat shock transcription factors 1 and 2 (HSF1 and HSF2) in HeLa cells and in yeast (Saccharomyces cerevisiae).", "output": {"entities": {"gene": [{"text": "beta-gal", "start": 32, "end": 40}, {"text": "human heat shock transcription factors 1 and 2", "start": 65, "end": 111}, {"text": "HSF1", "start": 113, "end": 117}, {"text": "HSF2", "start": 122, "end": 126}]}}, "schema": []}
{"input": "Localized fluorescence was detectable only in cells containing a visible midcell constriction, suggesting that FtsK targeting normally occurs only at a late stage of septation.", "output": {"entities": {"gene": [{"text": "FtsK", "start": 111, "end": 115}]}}, "schema": []}
{"input": "No TATA box was found in the putative promoter region, but multiple GC boxes were found around the cap sites, supporting the previously inferred housekeeping nature of CYP51 gene and the existence of the multiple transcription initiation sites.", "output": {"entities": {"gene": [{"text": "CYP51 gene", "start": 168, "end": 178}]}}, "schema": []}
{"input": "Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: I.", "output": {"entities": {"gene": [{"text": "sterol 14-demethylase P450", "start": 39, "end": 65}, {"text": "CYP51", "start": 67, "end": 72}, {"text": "P450 monooxygenase", "start": 94, "end": 112}]}}, "schema": []}
{"input": "Its expression pattern is representative of many B cell-specific proteins, which are essential for B cell development and activation but are down-regulated after B cells become terminally differentiated plasma cells.", "output": {"entities": {}}, "schema": []}
{"input": "The intercistronic gene junctions of vesicular stomatitis virus (VSV) contain conserved sequence elements that are important for polyadenylation and transcription termination of upstream transcript as well as reinitiation of transcription of downstream transcript.", "output": {"entities": {}}, "schema": []}
{"input": "Infectious mutant virus progeny was obtained only on complementing gK-expressing cells, suggesting that gK has an important function in the replication cycle.", "output": {"entities": {"gene": [{"text": "gK", "start": 67, "end": 69}, {"text": "gK", "start": 104, "end": 106}]}}, "schema": []}
{"input": "Cleavage and DNA joining reactions, carried out by human immunodeficiency virus type 1 (HIV-1) integrase, are necessary to effect the covalent insertion of HIV-1 DNA into the host genome.", "output": {"entities": {"gene": [{"text": "human immunodeficiency virus type 1 (HIV-1) integrase", "start": 51, "end": 104}]}}, "schema": []}
{"input": "The DSF regimen appears to have significant activity in patients who have metastatic pancreatic islet-cell carcinoma, and patient tolerance of the regimen is excellent, thus warranting further investigation.", "output": {"entities": {}}, "schema": []}
{"input": "Activation of the mitogen activated protein (MAP) kinase is a primary consequence of Ras activation and plays a key role in mediating Ras signal transduction.", "output": {"entities": {"gene": [{"text": "mitogen activated protein (MAP) kinase", "start": 18, "end": 56}, {"text": "Ras", "start": 85, "end": 88}, {"text": "Ras", "start": 134, "end": 137}]}}, "schema": []}
{"input": "Histone acetylation levels in cells result from a dynamic equilibrium between competing histone acetylases and deacetylases.", "output": {"entities": {"gene": [{"text": "Histone", "start": 0, "end": 7}, {"text": "histone acetylases and deacetylases", "start": 88, "end": 123}]}}, "schema": []}
{"input": "CyIIa transcription follows, and is therefore downstream of, the initial specification of these embryonic domains.", "output": {"entities": {"gene": [{"text": "CyIIa", "start": 0, "end": 5}]}}, "schema": []}
{"input": "Cis-regulation downstream of cell type specification: a single compact element controls the complex expression of the CyIIa gene in sea urchin embryos.", "output": {"entities": {"gene": [{"text": "CyIIa gene", "start": 118, "end": 128}]}}, "schema": []}
{"input": "We also present evidence that human HYAL1 is identical to an uncharacterized gene positionally cloned by others from chromosome 3p21. 3 that is homozygously deleted in several small-cell lung carcinoma cell lines.", "output": {"entities": {"gene": [{"text": "human HYAL1", "start": 30, "end": 41}]}}, "schema": []}
{"input": "In patients with myalgia, Raynaud' s syndrome, skin vasculitis and vascular diseases WFAg concentrations were higher than in patients without them.", "output": {"entities": {"gene": [{"text": "WFAg", "start": 85, "end": 89}]}}, "schema": []}
{"input": "Although the expression of the 4E-BP1 gene alone has not yet been accomplished, the gene was expressed in Escherichia coli [BL21 (DE3)] as a fusion gene with the glutathione-S-transferase (GST) gene using a prokaryotic gene fusion vector (pGEX-4T-2), which contains a gene sequence coding the cleavage site for a specific protease, alpha-thrombin.", "output": {"entities": {"gene": [{"text": "4E-BP1 gene", "start": 31, "end": 42}, {"text": "glutathione-S-transferase", "start": 162, "end": 187}, {"text": "GST", "start": 189, "end": 192}, {"text": "alpha-thrombin", "start": 332, "end": 346}]}}, "schema": []}
{"input": "Randomised comparison of addition of autologous bone-marrow transplantation to intensive chemotherapy for acute myeloid leukaemia in first remission: results of MRC AML 10 trial.", "output": {"entities": {}}, "schema": []}
{"input": "Therapeutic use of cannabis.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of intragenic revertants shows that this function depends on the amino acid preceding the first cysteine residue of the DNA-binding domain of Hap1p.", "output": {"entities": {"gene": [{"text": "Hap1p", "start": 151, "end": 156}]}}, "schema": []}
{"input": "Peripheral visual stimuli and monoaural auditory stimuli were used as targets.", "output": {"entities": {}}, "schema": []}
{"input": "A review of studies published between 1983 and 1995 shows that there are some common factors as regards the psychological distress and social and functional limitations this group of patients has to deal with.", "output": {"entities": {}}, "schema": []}
{"input": "PKC-gamma, which is not present in keratinocytes, also induces involucrin gene expression in a TPA-independent manner, when introduced into SVHK cells.", "output": {"entities": {"gene": [{"text": "PKC-gamma", "start": 0, "end": 9}, {"text": "involucrin gene", "start": 63, "end": 78}]}}, "schema": []}
{"input": "Identification and characterization of specific DNA-binding complexes containing members of the Myc/Max/Mad network of transcriptional regulators.", "output": {"entities": {"gene": [{"text": "Myc", "start": 96, "end": 99}, {"text": "Max", "start": 100, "end": 103}, {"text": "Mad", "start": 104, "end": 107}]}}, "schema": []}
{"input": "We further show that proteolytic targeting by calpain II and the proteasome involves different structural elements of YY1.", "output": {"entities": {"gene": [{"text": "calpain II", "start": 46, "end": 56}, {"text": "YY1", "start": 118, "end": 121}]}}, "schema": []}
{"input": "Primers for subsequent rounds of RACE were designed from the 5'-ends of amplified RACE products.", "output": {"entities": {}}, "schema": []}
{"input": "Human ZFM1 protein is a transcriptional repressor that interacts with the transcription activation domain of stage-specific activator protein.", "output": {"entities": {"gene": [{"text": "ZFM1 protein", "start": 6, "end": 18}, {"text": "transcription activation domain of stage-specific activator protein", "start": 74, "end": 141}]}}, "schema": []}
{"input": "Surprisingly, the CSF1R/IRDelta960 was as effective as the CSF1R/IR in mediating CSF-1 protection of cells from staurosporine-induced apoptosis.", "output": {"entities": {"gene": [{"text": "CSF1R", "start": 18, "end": 23}, {"text": "IRDelta960", "start": 24, "end": 34}, {"text": "CSF1R", "start": 59, "end": 64}, {"text": "IR", "start": 65, "end": 67}, {"text": "CSF-1", "start": 81, "end": 86}]}}, "schema": []}
{"input": "CONCLUSIONS: The special clinical presentation of our case of possible Gardner' s syndrome is discussed.", "output": {"entities": {}}, "schema": []}
{"input": "These results would suggest that a high UV sensitivity is associated with high phaeomelanin and low eumelanin levels, and point to the eumelanin/phaeomelanin ratio as a novel chemical parameter that could be used for predicting individuals at high risk for skin cancer and melanoma.", "output": {"entities": {}}, "schema": []}
{"input": "In ferrets naturally infected with H. mustelae, a single dose (50 mg/kg, per os) of fluorofamide completely inhibited bacterial urease.", "output": {"entities": {"gene": [{"text": "bacterial urease", "start": 118, "end": 134}]}}, "schema": []}
{"input": "The cAMP-dependent mitogenic pathway is unique as it is independent of mitogen-activated protein kinase activation and differs from growth factor-dependent pathways at the level of the expression of several protooncogenes/transcription factors.", "output": {"entities": {"gene": [{"text": "mitogen-activated protein kinase", "start": 71, "end": 103}]}}, "schema": []}
{"input": "CONCLUSIONS: Use of the first method was associated with a reduction in the time patients remained in the ICU before transfer to another unit and savings in nursing time, but the two methods did not differ according to clinical outcomes.", "output": {"entities": {}}, "schema": []}
{"input": "We have elucidated the exon-intron organization of the entire human CD58 gene, including approximately 2. 5 kilobases (kb) of 5'-flanking DNA.", "output": {"entities": {"gene": [{"text": "CD58 gene", "start": 68, "end": 77}]}}, "schema": []}
{"input": "The risk factors for hematuria in patients with renal hypouricemia are the elevation of urinary urate concentration and the subtypes of Post and Secretion.", "output": {"entities": {}}, "schema": []}
{"input": "Two hundred sixty-four patients scheduled for DCBM were randomized to receive intravenously geG 0. 25 mg (geG-25), or geG 0. 5 mg (geG-50), or HBB 20 mg as hypotonic agent.", "output": {"entities": {}}, "schema": []}
{"input": "If the haemoglobin concentration (Hb) was less than 12 g dL-1 they were given a four week course of ferrous sulphate.", "output": {"entities": {"gene": [{"text": "haemoglobin", "start": 7, "end": 18}, {"text": "Hb", "start": 34, "end": 36}]}}, "schema": []}
{"input": "Based on restriction enzyme analysis, Southern blots, polymerase chain reaction analysis and DNA sequencing, it was confirmed that the three overlapping clones isolated cover the entire cHO-1 gene, as well as approximately 10 kb of the flanking regions on both ends.", "output": {"entities": {"gene": [{"text": "cHO-1 gene", "start": 186, "end": 196}]}}, "schema": []}
{"input": "Position-independent expression of a human nerve growth factor-luciferase reporter gene cloned on a yeast artificial chromosome vector.", "output": {"entities": {"gene": [{"text": "nerve growth factor", "start": 43, "end": 62}, {"text": "luciferase", "start": 63, "end": 73}]}}, "schema": []}
{"input": "Calcitriol therapy was associated with a decrease in serum iPTH levels (701 +/-103. 9 vs.", "output": {"entities": {"gene": [{"text": "iPTH", "start": 59, "end": 63}]}}, "schema": []}
{"input": "Alterations in DNase I reactivity of the GC-response element region suggest that GC receptor-GC complexes may associate, in a transient manner, with the promoter in the actively transcribing control state.", "output": {"entities": {"gene": [{"text": "DNase I", "start": 15, "end": 22}, {"text": "GC receptor-GC complexes", "start": 81, "end": 105}]}}, "schema": []}
{"input": "Most pituitary hormone-coding gene promoters are activated by Ptx1.", "output": {"entities": {"gene": [{"text": "Ptx1", "start": 62, "end": 66}]}}, "schema": []}
{"input": "One of these small inteins might be inactive or a \" pseudo intein. \" The results suggest a modular architecture for inteins, clarify their origin and relationship to other protein families, and extend recent experimental findings on the functional roles of intein N, C, and EN motifs.", "output": {"entities": {"gene": [{"text": "small inteins", "start": 13, "end": 26}, {"text": "\" pseudo intein. \"", "start": 50, "end": 68}, {"text": "inteins", "start": 116, "end": 123}, {"text": "intein N, C, and EN motifs", "start": 257, "end": 283}]}}, "schema": []}
{"input": "Purification of MvaT enriched for two polypeptides of approximate molecular mass 15 kDa and 16 kDa, designated P15 and P16.", "output": {"entities": {"gene": [{"text": "MvaT", "start": 16, "end": 20}, {"text": "P15", "start": 111, "end": 114}, {"text": "P16", "start": 119, "end": 122}]}}, "schema": []}
{"input": "These results indicate that TGF-betaf potentiates the c-fos SRE activated by PKC through the SRF binding site.", "output": {"entities": {"gene": [{"text": "TGF-betaf", "start": 28, "end": 37}, {"text": "c-fos", "start": 54, "end": 59}, {"text": "PKC", "start": 77, "end": 80}, {"text": "SRF binding site", "start": 93, "end": 109}]}}, "schema": []}
{"input": "BACKGROUND: Defensins, also known as human neutrophil peptides, are antimicrobial peptides present in the azurophil granules of neutrophils.", "output": {"entities": {"gene": [{"text": "Defensins", "start": 12, "end": 21}, {"text": "human neutrophil peptides", "start": 37, "end": 62}]}}, "schema": []}
{"input": "The spontaneous mutation blocking pca gene expression was located in the promoter for the pca operon.", "output": {"entities": {"gene": [{"text": "pca gene", "start": 34, "end": 42}, {"text": "pca operon", "start": 90, "end": 100}]}}, "schema": []}
{"input": "From 250 g of cells, we isolated 1 mg of PDH complex with a specific activity of 12. 6 U/mg of protein.", "output": {"entities": {"gene": [{"text": "PDH complex", "start": 41, "end": 52}]}}, "schema": []}
{"input": "The PDH complex-encoding genes were identified by hybridization experiments and sequence analysis in two separate gene regions in the genome of Z. mobilis.", "output": {"entities": {"gene": [{"text": "PDH complex-encoding genes", "start": 4, "end": 30}]}}, "schema": []}
{"input": "We have identified two functional elements, both located downstream from the TATA motif, that control Id4 promoter activity.", "output": {"entities": {"gene": [{"text": "Id4 promoter", "start": 102, "end": 114}]}}, "schema": []}
{"input": "Azithromycin is a new generation macrolide antibiotic with unusual and favorable pharmacokinetics, and seems to be a very promising agent for innovative anti-H. pylori regimens.", "output": {"entities": {}}, "schema": []}
{"input": "The study enrolled 994 people co-infected with CMV and HIV, with at least one CD4 count recorded < 100 x 10 (6) cells/l.", "output": {"entities": {"gene": [{"text": "CD4", "start": 78, "end": 81}]}}, "schema": []}
{"input": "National certification: a vital component of quality assurance.", "output": {"entities": {}}, "schema": []}
{"input": "Two rare novel mutations, D811N in exon 20 and R835C in exon 21, were identified in the first nucleotide-binding fold (NBF), a functionally important region of SUR1, in one patient each, both heterozygotes.", "output": {"entities": {"gene": [{"text": "SUR1", "start": 160, "end": 164}]}}, "schema": []}
{"input": "Chimaeric VP16-E2 molecules suggest that the epithelial specific transcriptional activation of the BPV-4 LCR promoter is mediated by the E2 transactivation domain.", "output": {"entities": {"gene": [{"text": "VP16", "start": 10, "end": 14}, {"text": "E2", "start": 15, "end": 17}, {"text": "BPV-4 LCR promoter", "start": 99, "end": 117}, {"text": "E2 transactivation domain", "start": 137, "end": 162}]}}, "schema": []}
{"input": "These changes correlate directly with an increase in the acetylation levels of all four core histones in vivo.", "output": {"entities": {"gene": [{"text": "core histones", "start": 88, "end": 101}]}}, "schema": []}
{"input": "Drosophila orthodenticle (otd) and murine Otx genes exemplify this, both in terms of expression patterns and mutant phenotypes.", "output": {"entities": {"gene": [{"text": "Drosophila orthodenticle", "start": 0, "end": 24}, {"text": "otd", "start": 26, "end": 29}, {"text": "murine Otx genes", "start": 35, "end": 51}]}}, "schema": []}
{"input": "APETALA3 transcripts are first detected in a meristematic region that will give rise to the petal and stamen primordia, and expression is maintained in this region during subsequent development of these organs.", "output": {"entities": {"gene": [{"text": "APETALA3 transcripts", "start": 0, "end": 20}]}}, "schema": []}
{"input": "We also recovered mutations in the 60A gene which encodes another TGF-beta-related factor in Drosophila.", "output": {"entities": {"gene": [{"text": "60A gene", "start": 35, "end": 43}, {"text": "TGF-beta-related factor", "start": 66, "end": 89}]}}, "schema": []}
{"input": "Cell lines are checked to find out whether they develop tumors in nude mice followed by an analysis of the karyotype.", "output": {"entities": {}}, "schema": []}
{"input": "Cervicovaginal foetal fibronectin in the prediction of preterm labour in a low-risk population.", "output": {"entities": {"gene": [{"text": "foetal fibronectin", "start": 15, "end": 33}]}}, "schema": []}
{"input": "In addition, IgM can be absent in children with congenital toxoplasmosis or subjects with secondary reactivation.", "output": {"entities": {"gene": [{"text": "IgM", "start": 13, "end": 16}]}}, "schema": []}
{"input": "Both variants display the seven-transmembrane topology that is typical for G protein-coupled receptors.", "output": {"entities": {"gene": [{"text": "G protein-coupled receptors", "start": 75, "end": 102}]}}, "schema": []}
{"input": "A constitutive allele of GPA2 could stimulate growth of a strain lacking both RAS genes.", "output": {"entities": {"gene": [{"text": "GPA2", "start": 25, "end": 29}, {"text": "RAS genes", "start": 78, "end": 87}]}}, "schema": []}
{"input": "The COOH-terminus of this new isoform, which we designate beta 4, lacks a 22 amino acid lysine-rich sequence common to both the human red cell alpha-and beta-adducin subunits and homologous to a highly conserved region in MARCKS, a filamentous actin-cross linking protein regulated by protein kinase C and calcium/calmodulin. beta 4-adducin preserves a previously identified calmodulin binding domain.", "output": {"entities": {"gene": [{"text": "beta 4", "start": 58, "end": 64}, {"text": "human red cell alpha-and beta-adducin subunits", "start": 128, "end": 174}, {"text": "MARCKS", "start": 222, "end": 228}, {"text": "actin", "start": 244, "end": 249}, {"text": "protein kinase C", "start": 285, "end": 301}, {"text": "calmodulin", "start": 314, "end": 324}, {"text": "beta 4-adducin", "start": 326, "end": 340}, {"text": "calmodulin binding domain", "start": 375, "end": 400}]}}, "schema": []}
{"input": "PCR analysis indicates that this new beta-adducin isoform is expressed in fetal brain and liver, bone marrow, and NT-2 (neuroepithelial) cells, but is not detected in several other tissues.", "output": {"entities": {"gene": [{"text": "beta-adducin isoform", "start": 37, "end": 57}]}}, "schema": []}
{"input": "The gene lac-1, encoding the enzyme laccase, is the best characterized of a number of genes in the chestnut blight fungus, Cryphonectria parasitica, that are repressed by hypoviruses, a group of virulence-attenuating mycoviruses. lac-1 has also been shown to be transcriptionally activated by low concentrations of the translational inhibitor cycloheximide (CHX) and by the immunosuppressant cyclosporin A.", "output": {"entities": {"gene": [{"text": "gene lac-1", "start": 4, "end": 14}, {"text": "laccase", "start": 36, "end": 43}, {"text": "lac-1", "start": 230, "end": 235}]}}, "schema": []}
{"input": "Both TRE-like elements were capable of binding AP1.", "output": {"entities": {"gene": [{"text": "AP1", "start": 47, "end": 50}]}}, "schema": []}
{"input": "The hp55 gamma protein interacts strongly with the activated IGFIR but not with the kinase-negative mutant receptor. hp55 gamma also interacts with the insulin receptor (IR) in the yeast two-hybrid system.", "output": {"entities": {"gene": [{"text": "hp55 gamma protein", "start": 4, "end": 22}, {"text": "IGFIR", "start": 61, "end": 66}, {"text": "hp55 gamma", "start": 117, "end": 127}, {"text": "insulin receptor", "start": 152, "end": 168}, {"text": "IR", "start": 170, "end": 172}]}}, "schema": []}
{"input": "The plant protein maintains all the functional domains found in the other proteins, including nuclear localization signal, DNA-binding domain and helicase motifs, suggesting that it might also act as part of the RNA transcription apparatus, as well as nucleotide excision repair in plant cells.", "output": {"entities": {"gene": [{"text": "helicase motifs", "start": 146, "end": 161}]}}, "schema": []}
{"input": "This paper describes the genomic organization of mouse gC1qBP and the characterization of its 5' flanking region.", "output": {"entities": {"gene": [{"text": "gC1qBP", "start": 55, "end": 61}]}}, "schema": []}
{"input": "LysR proteins have been shown to regulate urease in Klebsiella aerogenes (NAC), and catalase in Escherichia coli (OxyR), which offers the intracellular bacterium protection from phagolysosome damage.", "output": {"entities": {"gene": [{"text": "LysR proteins", "start": 0, "end": 13}, {"text": "urease in Klebsiella aerogenes", "start": 42, "end": 72}, {"text": "NAC", "start": 74, "end": 77}, {"text": "catalase in Escherichia coli", "start": 84, "end": 112}, {"text": "OxyR", "start": 114, "end": 118}]}}, "schema": []}
{"input": "Also, the anti-inflammatory activities of an aqueous extract of Buddleia cordata and its principal glycoside linarin were evaluated.", "output": {"entities": {}}, "schema": []}
{"input": "Regulation of the Raf kinase in T cells differs from findings with a variety of cell lines that the catalytic domain of Raf (Raf (delta26-303)) shows no activity.", "output": {"entities": {"gene": [{"text": "Raf kinase", "start": 18, "end": 28}, {"text": "catalytic domain of Raf", "start": 100, "end": 123}, {"text": "Raf", "start": 125, "end": 128}]}}, "schema": []}
{"input": "Full-length FLAP clones were isolated from a mouse skeletal muscle cDNA library.", "output": {"entities": {"gene": [{"text": "Full-length FLAP", "start": 0, "end": 16}]}}, "schema": []}
{"input": "We have visualized DNA-protein complexes by electron microscopy and a high-affinity binding site of WDV Rep protein within the core element has been mapped to approximately 144 +/-18 bp upstream from the initiation site, between the start site for complementary-sense transcription and the TATA box.", "output": {"entities": {"gene": [{"text": "WDV Rep protein", "start": 100, "end": 115}]}}, "schema": []}
{"input": "Rex-1, a gene encoding a transcription factor expressed in the early embryo, is regulated via Oct-3/4 and Oct-6 binding to an octamer site and a novel protein, Rox-1, binding to an adjacent site.", "output": {"entities": {"gene": [{"text": "Rex-1", "start": 0, "end": 5}, {"text": "Oct-3/4", "start": 94, "end": 101}, {"text": "Oct-6", "start": 106, "end": 111}, {"text": "Rox-1", "start": 160, "end": 165}]}}, "schema": []}
{"input": "However, inhibition of both the ERK/RSK and the p38/MAPKAP kinase 2 pathways completely abolished NGF-induced CREB Ser-133 phosphorylation.", "output": {"entities": {"gene": [{"text": "ERK", "start": 32, "end": 35}, {"text": "RSK", "start": 36, "end": 39}, {"text": "p38", "start": 48, "end": 51}, {"text": "MAPKAP kinase 2", "start": 52, "end": 67}, {"text": "NGF", "start": 98, "end": 101}, {"text": "CREB", "start": 110, "end": 114}]}}, "schema": []}
{"input": "Cells respond to the accumulation of unfolded proteins in the endoplasmic reticulum (ER) by increasing the transcription of the genes encoding ER-resident chaperone proteins.", "output": {"entities": {"gene": [{"text": "ER-resident chaperone proteins", "start": 143, "end": 173}]}}, "schema": []}
{"input": "The mei4 + gene of the fission yeast Schizosaccharomyces pombe was cloned by functional complementation.", "output": {"entities": {"gene": [{"text": "mei4 + gene", "start": 4, "end": 15}]}}, "schema": []}
{"input": "In some cases, the aberrant methylation of CpGs within 5' regulatory regions has led to suppression of gene activity.", "output": {"entities": {}}, "schema": []}
{"input": "The genomic fragments were fused upstream of the luciferase reporter gene.", "output": {"entities": {"gene": [{"text": "luciferase reporter gene", "start": 49, "end": 73}]}}, "schema": []}
{"input": "Cotransfection analyses of the T/EBP promoter-reporter constructs with a T/EBP expression vector into human HepG2 cells, which do not express T/EBP, suggested that autoregulation may be involved in controlling both rat and human T/EBP gene expression.", "output": {"entities": {"gene": [{"text": "T/EBP promoter-reporter constructs", "start": 31, "end": 65}, {"text": "T/EBP", "start": 73, "end": 78}, {"text": "T/EBP", "start": 142, "end": 147}, {"text": "human T/EBP gene", "start": 223, "end": 239}]}}, "schema": []}
{"input": "Deletion of the last two Ser residues, including one PKC consensus site in the receptor tail, prevented only phorbol 12-myristate 13-acetate-induced desensitization by 30%.", "output": {"entities": {"gene": [{"text": "PKC", "start": 53, "end": 56}]}}, "schema": []}
{"input": "Flap survival depends on the development of a small number of vascular connections between vessels arising from the pedicle and preexisting dermal vessels.", "output": {"entities": {}}, "schema": []}
{"input": "Jean Klig reviews recent literature about lower respiratory tract infection in children.", "output": {"entities": {}}, "schema": []}
{"input": "Potential indicators were assessed for the two classifications of protein-energy malnutrition in the guidelines for integrated management of childhood illness: severe malnutrition, which requires immediate referral to hospital, and very low weight, which calls for feeding assessment, nutritional counselling and follow-up.", "output": {"entities": {}}, "schema": []}
{"input": "Despite its requirement for enhancer-dependent splicing activity in vitro, the dU2AF38 RS domain was also inessential in vivo.", "output": {"entities": {"gene": [{"text": "dU2AF38 RS domain", "start": 79, "end": 96}]}}, "schema": []}
{"input": "In vitro binding studies using GST fusion proteins and yeast extracts defined distinct binding sites on yAP180A for Pan1p and clathrin. yAP180 proteins and Pan1p, like actin, localize to peripheral patches along the plasma membrane.", "output": {"entities": {"gene": [{"text": "GST", "start": 31, "end": 34}, {"text": "yAP180A", "start": 104, "end": 111}, {"text": "Pan1p", "start": 116, "end": 121}, {"text": "clathrin", "start": 126, "end": 134}, {"text": "yAP180 proteins", "start": 136, "end": 151}, {"text": "Pan1p", "start": 156, "end": 161}, {"text": "actin", "start": 168, "end": 173}]}}, "schema": []}
{"input": "In vitro affinity analyses demonstrated that recombinant 130-kD protein directly interacts with ZO-1 and the cytoplasmic domain of occludin, but not with ZO-2.", "output": {"entities": {"gene": [{"text": "ZO-1", "start": 96, "end": 100}, {"text": "occludin", "start": 131, "end": 139}, {"text": "ZO-2", "start": 154, "end": 158}]}}, "schema": []}
{"input": "Cytochrome b in human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of the components in liver mitochondria and chromosome assignment of the genes for the large (SDHC) and small (SDHD) subunits to 1q21 and 11q23.", "output": {"entities": {"gene": [{"text": "Cytochrome b", "start": 0, "end": 12}, {"text": "human complex II", "start": 16, "end": 32}, {"text": "succinate-ubiquinone oxidoreductase", "start": 34, "end": 69}, {"text": "SDHC", "start": 179, "end": 183}, {"text": "SDHD", "start": 196, "end": 200}]}}, "schema": []}
{"input": "A possible decrease in theophylline' s volume of distribution at 4 days, but not immediately, after administration of chloroquine was suggested, although this just failed to achieve statistical significance (p = 0. 055).", "output": {"entities": {}}, "schema": []}
{"input": "The addition of a Paf-containing extract does not lead to significant protein binding to these two hly target sequences in the absence of PrfA but converts the complex (CIII) consisting of PrfA and the 109 bp hly DNA fragment to a slower migrating PrfA-Paf-DNA complex (CI).", "output": {"entities": {"gene": [{"text": "Paf", "start": 18, "end": 21}, {"text": "hly target sequences", "start": 99, "end": 119}, {"text": "PrfA", "start": 138, "end": 142}, {"text": "PrfA", "start": 189, "end": 193}, {"text": "109 bp hly DNA fragment", "start": 202, "end": 225}, {"text": "PrfA", "start": 248, "end": 252}, {"text": "Paf", "start": 253, "end": 256}]}}, "schema": []}
{"input": "ROCK-I, Kinectin, and mDia2 can bind the wild type forms of both RhoA and Cdc42 in a GTP-dependent manner in vitro.", "output": {"entities": {"gene": [{"text": "ROCK-I", "start": 0, "end": 6}, {"text": "Kinectin", "start": 8, "end": 16}, {"text": "mDia2", "start": 22, "end": 27}, {"text": "RhoA", "start": 65, "end": 69}, {"text": "Cdc42", "start": 74, "end": 79}]}}, "schema": []}
{"input": "Among three isoforms, the beta isoform has the greatest Vmax value for the PtdIns (4) P kinase activity and the gamma isoform is most markedly stimulated by phosphatidic acid.", "output": {"entities": {"gene": [{"text": "PtdIns (4) P kinase", "start": 75, "end": 94}]}}, "schema": []}
{"input": "The beta subunit of the heterotrimeric G proteins that transduce signals across the plasma membrane is made up of an amino-terminal alpha-helical segment followed by seven repeating units called WD (Trp-Asp) repeats that occur in about 140 different proteins.", "output": {"entities": {"gene": [{"text": "heterotrimeric G proteins", "start": 24, "end": 49}]}}, "schema": []}
{"input": "Two differentially expressed LNX messages encode overlapping proteins with predicted molecular masses of 80 kDa (LNX) and 70 kDa (LNX-b).", "output": {"entities": {"gene": [{"text": "LNX messages", "start": 29, "end": 41}, {"text": "80 kDa (LNX)", "start": 105, "end": 117}, {"text": "70 kDa (LNX-b)", "start": 122, "end": 136}]}}, "schema": []}
{"input": "In contrast, the contractile action of arachidonic acid, via a presumed cyclooxygenase product that mediated the contractions caused by both TF and EGF, was not blocked by any of the signal pathway probe inhibitors.", "output": {"entities": {"gene": [{"text": "cyclooxygenase", "start": 72, "end": 86}, {"text": "TF", "start": 141, "end": 143}, {"text": "EGF", "start": 148, "end": 151}]}}, "schema": []}
{"input": "On a separate occasion the T1 weighted and T2 weighted sagittal and T2 weighted axial sequences were reported blind in relation to the initial assessment.", "output": {"entities": {}}, "schema": []}
{"input": "The iron dependence of transcription and expression of cvaA, which encodes a transporter accessory protein, and cvi, encoding the colicin V immunity protein, was assessed under conditions of iron excess or depletion.", "output": {"entities": {"gene": [{"text": "cvaA", "start": 55, "end": 59}, {"text": "cvi", "start": 112, "end": 115}, {"text": "colicin V immunity protein", "start": 130, "end": 156}]}}, "schema": []}
{"input": "Furthermore, the deletion of bcp from the chromosome had no effect on gcv-lacZ expression.", "output": {"entities": {"gene": [{"text": "bcp", "start": 29, "end": 32}, {"text": "gcv", "start": 70, "end": 73}, {"text": "lacZ", "start": 74, "end": 78}]}}, "schema": []}
{"input": "Of these sites, PEA3 and STAT contributed specifically to induction by v-src, whereas the remaining elements were also involved in induction by the phorbol ester phorbol myristate acetate (PMA).", "output": {"entities": {"gene": [{"text": "PEA3", "start": 16, "end": 20}, {"text": "STAT", "start": 25, "end": 29}, {"text": "v-src", "start": 71, "end": 76}]}}, "schema": []}
{"input": "BRCA1 protein contains an amino-terminal zinc finger motif and a carboxy-terminal acidic region.", "output": {"entities": {"gene": [{"text": "BRCA1 protein", "start": 0, "end": 13}]}}, "schema": []}
{"input": "The mitochondrial regulatory region (mrr) located between the tRNAPhe and tRNAPro genes of mitochondrial DNA (mtDNA) is essential for regulation of replication and transcription of the mitochondrial genome.", "output": {"entities": {"gene": [{"text": "mitochondrial regulatory region", "start": 4, "end": 35}, {"text": "mrr", "start": 37, "end": 40}, {"text": "tRNAPhe", "start": 62, "end": 69}, {"text": "tRNAPro genes", "start": 74, "end": 87}]}}, "schema": []}
{"input": "In this report, we investigate the mechanism underlying Ras activation upon stimulation of these two types of receptors in hematopoietic cells.", "output": {"entities": {"gene": [{"text": "Ras", "start": 56, "end": 59}]}}, "schema": []}
{"input": "Thus, Sir proteins from K. lactis have roles in both silencing and telomere length maintenance, reflecting conserved functional themes.", "output": {"entities": {"gene": [{"text": "Sir proteins", "start": 6, "end": 18}]}}, "schema": []}
{"input": "These mutants were tested for ability to bind each of the Site II cognate proteins, and subsequently evaluated for ability to confer H4 transcriptional activity using chimeric H4 promoter/CAT fusion constructs in different cell types.", "output": {"entities": {"gene": [{"text": "Site II cognate proteins", "start": 58, "end": 82}, {"text": "H4", "start": 133, "end": 135}, {"text": "H4", "start": 176, "end": 178}, {"text": "CAT", "start": 188, "end": 191}]}}, "schema": []}
{"input": "Increased plasma IgE was also confirmed in the NC mice, and treatment with FK506 ointment reduced the plasma IgE level.", "output": {"entities": {"gene": [{"text": "IgE", "start": 17, "end": 20}, {"text": "IgE", "start": 109, "end": 112}]}}, "schema": []}
{"input": "Furthermore, in the ischemia/angiotension II-induced AHF model, NIC decreased left ventricular end-diastolic pressure (LVEDP).", "output": {"entities": {"gene": [{"text": "angiotension II", "start": 29, "end": 44}]}}, "schema": []}
{"input": "Group A (68. 7 +/-2. 7 years) consisted of patients with 0 or 1 risk factors; B (68. 3 +/-4. 2 years) those with 2 risk factors; and C (69. 2 +/-3. 6 years) those with 3 or more risk factors.", "output": {"entities": {}}, "schema": []}
{"input": "We further demonstrate that RU486-PR-B interacts physically with NCoR in vitro.", "output": {"entities": {"gene": [{"text": "PR-B", "start": 34, "end": 38}, {"text": "NCoR", "start": 65, "end": 69}]}}, "schema": []}
{"input": "PRL receptor also activates SHP-2, a cytosolic tyrosine phosphatase.", "output": {"entities": {"gene": [{"text": "PRL receptor", "start": 0, "end": 12}, {"text": "SHP-2", "start": 28, "end": 33}, {"text": "cytosolic tyrosine phosphatase", "start": 37, "end": 67}]}}, "schema": []}
{"input": "The dominant negative mutant of SHP-2 was found to inhibit the induction of tyrosine phosphorylation and DNA-binding activity of m-Stat5a, m-Stat5b, and the carboxyl-terminal deletion variant m-Stat5adelta749, as well as the transactivation potential of m-Stat5a and m-Stat5b.", "output": {"entities": {"gene": [{"text": "SHP-2", "start": 32, "end": 37}, {"text": "m-Stat5a", "start": 129, "end": 137}, {"text": "m-Stat5b", "start": 139, "end": 147}, {"text": "m-Stat5adelta749", "start": 192, "end": 208}, {"text": "m-Stat5a", "start": 254, "end": 262}, {"text": "m-Stat5b", "start": 267, "end": 275}]}}, "schema": []}
{"input": "CONCLUSIONS: These routinely collected data provided quantitative estimates of changes in CBZ Cl/F due to comedication and an age-related decrease in Cl/F The derived regression equations reasonably predicted concentrations in a separate validation set.", "output": {"entities": {}}, "schema": []}
{"input": "Sites 1 and 4 in lumican and keratocan are in a homologous location.", "output": {"entities": {"gene": [{"text": "lumican", "start": 17, "end": 24}, {"text": "keratocan", "start": 29, "end": 38}]}}, "schema": []}
{"input": "ATP-dependent assembly of a ternary complex consisting of a DNA mismatch and the yeast MSH2-MSH6 and MLH1-PMS1 protein complexes.", "output": {"entities": {"gene": [{"text": "MSH2", "start": 87, "end": 91}, {"text": "MSH6", "start": 92, "end": 96}, {"text": "MLH1", "start": 101, "end": 105}, {"text": "PMS1", "start": 106, "end": 110}]}}, "schema": []}
{"input": "Mutation of the central Tyr497 to Phe blocks the tyrosine phosphorylation of the insulin receptor substrate 1 (IRS1) and diminishes proliferation in response to IL-4.", "output": {"entities": {"gene": [{"text": "insulin receptor substrate 1", "start": 81, "end": 109}, {"text": "IRS1", "start": 111, "end": 115}, {"text": "IL-4", "start": 161, "end": 165}]}}, "schema": []}
{"input": "Instead, it contained two tandem kappaB elements and a variant activating transcription factor/cAMP response element site, which closely resembled sites in the E-selectin gene that are required for TNF-alpha-or LPS-inducible expression.", "output": {"entities": {"gene": [{"text": "kappaB elements", "start": 33, "end": 48}, {"text": "activating transcription factor/cAMP response element", "start": 63, "end": 116}, {"text": "E-selectin gene", "start": 160, "end": 175}, {"text": "TNF-alpha", "start": 198, "end": 207}]}}, "schema": []}
{"input": "Interestingly, the activated PDGF beta-receptor was found not to bind Crk proteins.", "output": {"entities": {"gene": [{"text": "PDGF beta-receptor", "start": 29, "end": 47}, {"text": "Crk proteins", "start": 70, "end": 82}]}}, "schema": []}
{"input": "Furthermore, interactions were identified between endogenous E-cadherin and the chimera containing the E-cadherin extracellular domain and the desmoglein 1 intracellular domain providing in vivo evidence for previously predicted lateral interactions of E-cadherin extracellular domains.", "output": {"entities": {"gene": [{"text": "endogenous E-cadherin", "start": 50, "end": 71}, {"text": "E-cadherin extracellular domain", "start": 103, "end": 134}, {"text": "desmoglein 1 intracellular domain", "start": 143, "end": 176}, {"text": "E-cadherin extracellular domains", "start": 253, "end": 285}]}}, "schema": []}
{"input": "The ether phospholipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OCH3; edelfosine) is a potent inducer of apoptosis in human tumor cells.", "output": {"entities": {}}, "schema": []}
{"input": "In addition to a previously characterized promoter (P1), we now show the existence of a second promoter for the human IL-5Ralpha gene.", "output": {"entities": {"gene": [{"text": "human IL-5Ralpha gene", "start": 112, "end": 133}]}}, "schema": []}
{"input": "Serum levels of testosterone also showed no significant changes by exposure to p, p'-DDE under the conditions of this study.", "output": {"entities": {}}, "schema": []}
{"input": "Overall agreement between rest/postnitroglycerin technetium-99m tetrofosmin SPET studies and rest/redistribution or rest/reinjection thallium-201 SPET studies, regarding the presence of myocardial viability, was 87% and 90%, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Their use resulted in a sensitivity of 73% and a specificity of 74% with regard to predictability of ALT levels increasing during the trial.", "output": {"entities": {"gene": [{"text": "ALT", "start": 101, "end": 104}]}}, "schema": []}
{"input": "One hundred replicate data sets of 100 subjects each were simulated for each missing data scenario.", "output": {"entities": {}}, "schema": []}
{"input": "Spatial accuracy of primary and secondary memory-guided saccades in schizophrenic patients.", "output": {"entities": {}}, "schema": []}
{"input": "Successful treatment with nasal continuous positive airway pressure (8. 3 +/-1. 5 cmH2O) for 3 days caused a significant decrease in mean blood pressure in OSAS.", "output": {"entities": {}}, "schema": []}
{"input": "When data were expressed in a cumulative manner, the response to intravenous adenosine 3 mg, 6 mg, 9 mg and 12 mg in the 24 episodes of PSVT were 5 episodes (21%), 16 episodes (67%), 20 episodes (83%) and 20 episodes (83%) respectively.", "output": {"entities": {}}, "schema": []}
{"input": "RNAs are not only essential components of both ribosomal subunits but also transiently interacting factors during particle formation.", "output": {"entities": {}}, "schema": []}
{"input": "To study retinoid signalling in zebrafish embryos, we developed a novel method to detect endogenous retinoids in situ in embryos, using a fusion protein of the ligand inducible transactivation domain of a retinoic acid receptor and a heterologous DNA binding domain.", "output": {"entities": {"gene": [{"text": "retinoic acid receptor", "start": 205, "end": 227}]}}, "schema": []}
{"input": "Fluorescence in situ hybridization of metaphase spreads of chromosome 8, containing hybrid cell line 706-B6 clone 17 (CL-17) with cosmid c101F1, placed the 9804 gene close to the telomere at 8q24. 3.", "output": {"entities": {"gene": [{"text": "9804 gene", "start": 156, "end": 165}]}}, "schema": []}
{"input": "Cell survival by Epo did not require activation of other known signaling pathways including PI-3 kinase, PLC-gamma, Ras or Stats.", "output": {"entities": {"gene": [{"text": "Epo", "start": 17, "end": 20}, {"text": "PI-3 kinase", "start": 92, "end": 103}, {"text": "PLC-gamma", "start": 105, "end": 114}, {"text": "Ras", "start": 116, "end": 119}, {"text": "Stats", "start": 123, "end": 128}]}}, "schema": []}
{"input": "The N-syndecan-dependent neurite outgrowth is inhibited by the tyrosine kinase inhibitors herbimycin A and PP1.", "output": {"entities": {"gene": [{"text": "tyrosine kinase", "start": 63, "end": 78}, {"text": "PP1", "start": 107, "end": 110}]}}, "schema": []}
{"input": "An in vivo ZAP-70 substrate, SLP-76, implicated in Erk activation, also became rapidly tyrosine-phosphorylated in Jurkat cells, but not in P116 cells, upon treatment with H2O2.", "output": {"entities": {"gene": [{"text": "ZAP-70", "start": 11, "end": 17}, {"text": "SLP-76", "start": 29, "end": 35}, {"text": "Erk", "start": 51, "end": 54}]}}, "schema": []}
{"input": "The pharmacokinetic patterns of estradiol (CAS 50-28-2) and of estrone (CAS 53-16-7) were investigated in 18 women in natural or surgical menopause during the application of a new estradiol transdermal patch with active matrix and without absorption enhancers designed for epicutaneous applications of 7 days (hereinafter called \" patch 7D \").", "output": {"entities": {}}, "schema": []}
{"input": "Conversely, the central regions are highly variable.", "output": {"entities": {}}, "schema": []}
{"input": "Among the H/ACA snoRNAs associated with Gar1p, one can distinguish a large group of snoRNAs that are not essential in yeast and serve as guides for pseudouridine synthesis onto the pre-rRNA molecule.", "output": {"entities": {"gene": [{"text": "H/ACA snoRNAs", "start": 10, "end": 23}, {"text": "Gar1p", "start": 40, "end": 45}]}}, "schema": []}
{"input": "Further studies demonstrated that the PPARalpha ligand 8 (S)-hydroxyeicosatetraenoic acid strongly promotes the interaction of PPARalpha with the co-activator RIP-140 but decreases the interaction of PPARalpha with the co-repressor SMRT.", "output": {"entities": {"gene": [{"text": "PPARalpha", "start": 38, "end": 47}, {"text": "PPARalpha", "start": 127, "end": 136}, {"text": "RIP-140", "start": 159, "end": 166}, {"text": "PPARalpha", "start": 200, "end": 209}, {"text": "SMRT", "start": 232, "end": 236}]}}, "schema": []}
{"input": "We previously demonstrated that acute expression of the bovine papillomavirus type 1 (BPV1) E2 protein in HeLa and HT-3 cervical carcinoma cell lines greatly reduced cellular proliferation by imposing a specific G1/S phase growth arrest.", "output": {"entities": {"gene": [{"text": "E2 protein", "start": 92, "end": 102}]}}, "schema": []}
{"input": "Four possible isoforms (hGli2 alpha, beta, gamma, and delta) are formed by combinations of two independent alternative splicings, and all the isoforms could bind to a DNA motif, TRE2S, in the LTR.", "output": {"entities": {"gene": [{"text": "hGli2 alpha, beta, gamma, and delta", "start": 24, "end": 59}]}}, "schema": []}
{"input": "Specialized actin tails that propel IEV particles to the periphery and virus-tipped microvilli (both common in wild-type-infected cells) were absent in cells infected with vA33delta.", "output": {"entities": {"gene": [{"text": "actin", "start": 12, "end": 17}]}}, "schema": []}
{"input": "Their mean IOP was 15. 3 (SD 3. 7) mmHg prior to induction of anesthesia, 13. 5 (SD 3. 5) mmHg after loss of eyelash reflex following injection of methohexitone, 16. 1 (SD 2. 4) mmHg after cessation of muscle fasciculations induced by suxamethonium, 19. 2 (SD 5. 6) mmHg after cessation of convulsion and 15. 5 (SD 4. 4) mmHg following resumption of regular spontaneous respiration.", "output": {"entities": {}}, "schema": []}
{"input": "A cDNA, cak1At, was isolated that suppressed the CAK mutation in budding yeast, and it also complemented a fission yeast CAK mutant. cak1At encodes a protein related to animal CAKs.", "output": {"entities": {"gene": [{"text": "cak1At", "start": 8, "end": 14}, {"text": "CAK mutation", "start": 49, "end": 61}, {"text": "fission yeast CAK mutant", "start": 107, "end": 131}, {"text": "cak1At", "start": 133, "end": 139}, {"text": "animal CAKs", "start": 169, "end": 180}]}}, "schema": []}
{"input": "Post-translational modifications such as glycosylation and phosphorylation could be excluded as potential explanations for the protein heterogeneity.", "output": {"entities": {}}, "schema": []}
{"input": "In addition to restoring checkpoint control, overexpression of sum1 + inhibits the normal cell cycle response to osmotic stress.", "output": {"entities": {"gene": [{"text": "sum1 +", "start": 63, "end": 69}]}}, "schema": []}
{"input": "Ime1 plays a pivotal role in the initiation of meiosis in a/alpha diploid cells of Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "Ime1", "start": 0, "end": 4}]}}, "schema": []}
{"input": "Rhesus macaques and BALB/c mice inoculated with the Mengo virus SIV recombinants failed to develop CTL responses against the SIV gene products, while one of the HIV-Nef recombinants induced a weak CTL response in mice directed to an HIV1 Nef peptide spanning positions 182-198.", "output": {"entities": {"gene": [{"text": "HIV-Nef recombinants", "start": 161, "end": 181}, {"text": "HIV1 Nef peptide", "start": 233, "end": 249}]}}, "schema": []}
{"input": "Deltamethrin was most effective on the thatched surface and produced 100% mortality of An. culicifacies adults up to 12 weeks, even when exposed at the lowest dose/12. 5 mg/m2.", "output": {"entities": {}}, "schema": []}
{"input": "Trichloroethylene, in turn, increased the AUC 5. 0 (1. 9-13. 4), 25. 8 (8. 2-80. 8) and 2. 9 (1. 6-5. 4), respectively, whereas the corresponding values for n-hexane were 1. 9 (0. 7-5. 1), 1. 5 (0. 5-4. 6), and 3. 2 (1. 8-5. 9).", "output": {"entities": {}}, "schema": []}
{"input": "Solution structure of the IRF-2 DNA-binding domain: a novel subgroup of the winged helix-turn-helix family.", "output": {"entities": {"gene": [{"text": "IRF-2 DNA-binding domain", "start": 26, "end": 50}, {"text": "winged helix-turn-helix family", "start": 76, "end": 106}]}}, "schema": []}
{"input": "In contrast, receptor/G protein coupling appeared unaffected by expression of loop 3i domains derived from two receptors coupled to G (i/o) proteins (M2Ach-muscarinic and alpha2A-adrenergic receptors).", "output": {"entities": {"gene": [{"text": "receptor/G protein", "start": 13, "end": 31}, {"text": "G (i/o) proteins", "start": 132, "end": 148}, {"text": "M2Ach-muscarinic and alpha2A-adrenergic receptors", "start": 150, "end": 199}]}}, "schema": []}
{"input": "These data indicate that the third intracellular loop of the rat GnRH-R is involved in receptor G (q/11) protein coupling and/or selectivity, and in the GGH (3) 1' cell line, this loop is also involved in signal transduction mediated through the Gs protein pathway.", "output": {"entities": {"gene": [{"text": "rat GnRH-R", "start": 61, "end": 71}, {"text": "receptor G (q/11) protein", "start": 87, "end": 112}, {"text": "Gs", "start": 246, "end": 248}]}}, "schema": []}
{"input": "Decreased levels of alpha2-antiplasmin were also observed in the mediastinum (0. 50 versus 0. 61 U/mL; p < 0. 05).", "output": {"entities": {"gene": [{"text": "alpha2-antiplasmin", "start": 20, "end": 38}]}}, "schema": []}
{"input": "A catalytic domain of eukaryotic DNA topoisomerase I.", "output": {"entities": {"gene": [{"text": "eukaryotic DNA topoisomerase I", "start": 22, "end": 52}]}}, "schema": []}
{"input": "A cluster of basic amino acids, KKKR, generated by joining of the sequences encoded by the constitutive exon 13 and the alternative exon 16, is necessary for the nuclear targeting of 4. 1H, as demonstrated by site-directed mutagenesis analysis.", "output": {"entities": {"gene": [{"text": "4. 1H", "start": 183, "end": 188}]}}, "schema": []}
{"input": "All three genes have been mapped precisely to a small region on human chromosome 16p12. 1-p11. 2 (homologous to mouse chromosome 7), using somatic cell hybrids and cosmid clones.", "output": {"entities": {}}, "schema": []}
{"input": "In fus3 mutants, the levels of Ty1 RNA, protein synthesis, and proteolytic processing were not altered relative to those in FUS3 strains but steady-state levels of TyA, integrase, and reverse transcriptase proteins and Ty1 cDNA were all increased.", "output": {"entities": {"gene": [{"text": "fus3 mutants", "start": 3, "end": 15}, {"text": "Ty1 RNA", "start": 31, "end": 38}, {"text": "FUS3", "start": 124, "end": 128}, {"text": "TyA", "start": 164, "end": 167}, {"text": "integrase", "start": 169, "end": 178}, {"text": "reverse transcriptase", "start": 184, "end": 205}, {"text": "Ty1 cDNA", "start": 219, "end": 227}]}}, "schema": []}
{"input": "Posttranslational regulation of Ty1 retrotransposition by mitogen-activated protein kinase Fus3.", "output": {"entities": {"gene": [{"text": "Ty1", "start": 32, "end": 35}, {"text": "mitogen-activated protein kinase Fus3", "start": 58, "end": 95}]}}, "schema": []}
{"input": "Their function is not only to recruit Pho2 to the promoter but to allow cooperative binding of Pho4 together with Pho2.", "output": {"entities": {"gene": [{"text": "Pho2", "start": 38, "end": 42}, {"text": "Pho4", "start": 95, "end": 99}, {"text": "Pho2", "start": 114, "end": 118}]}}, "schema": []}
{"input": "Substitution of the Ser-Thr sites with the phosphomimetic Asp generated a constitutively active form of IRF-3 that functioned as a very strong activator of promoters containing PRDI-PRDIII or ISRE regulatory elements.", "output": {"entities": {"gene": [{"text": "IRF-3", "start": 104, "end": 109}, {"text": "PRDI", "start": 177, "end": 181}, {"text": "PRDIII", "start": 182, "end": 188}, {"text": "ISRE regulatory elements", "start": 192, "end": 216}]}}, "schema": []}
{"input": "New-onset angina preceding acute myocardial infarction is associated with improved contractile recovery after thrombolysis.", "output": {"entities": {}}, "schema": []}
{"input": "In this study, the effect of acute administration of various doses of malathion via oral and dermal routes to mice and rats on serum levels of histamine was evaluated.", "output": {"entities": {}}, "schema": []}
{"input": "Fetal growth retardation as a cause of impaired ovarian development.", "output": {"entities": {}}, "schema": []}
{"input": "Similarly, PCDFs/PCDDs ratio in ESP ash was lower than that in boiler ash.", "output": {"entities": {}}, "schema": []}
{"input": "In addition to DNA-protein interactions, protein-protein interactions with partner proteins often play major roles in targeting ETS-domain proteins to specific promoters.", "output": {"entities": {"gene": [{"text": "ETS-domain proteins", "start": 128, "end": 147}]}}, "schema": []}
{"input": "The complete exon-intron organization of the murine gene encoding M-protein, a structural protein of sarcomeric myofibrils, was determined.", "output": {"entities": {"gene": [{"text": "M-protein", "start": 66, "end": 75}]}}, "schema": []}
{"input": "PURPOSE: To introduce an image analysis of the cornea in photorefractive keratectomy (PRK) for preoperative and early postoperative determination of changes in the condition of the cornea.", "output": {"entities": {}}, "schema": []}
{"input": "Mean +/-SD serum VEGF concentrations were significantly higher (P < 0. 001) in women with PCO and PCOS (3. 4 +/-0. 7 and 3. 2 +/-0. 66 ng/ml respectively) compared with women with normal ovaries (2. 3 +/-0. 5 ng/ml).", "output": {"entities": {"gene": [{"text": "serum VEGF", "start": 11, "end": 21}]}}, "schema": []}
{"input": "Strikingly, these cells contain a missense mutation of the p53 gene at codon 242 (p53 (242)), which substitutes alanine for glycine.", "output": {"entities": {"gene": [{"text": "p53 gene", "start": 59, "end": 67}, {"text": "p53", "start": 82, "end": 85}]}}, "schema": []}
{"input": "The new algorithm, called RBI-MAP, is based on the rescaled block iterative EM (RBI-EM) algorithm.", "output": {"entities": {}}, "schema": []}
{"input": "A third ORF, ORF5, shows homology with gene agrB from Staphylococcus aureus, which is involved in the mechanism of regulation of the virulence phenotype in this species.", "output": {"entities": {"gene": [{"text": "gene agrB", "start": 39, "end": 48}]}}, "schema": []}
{"input": "An association between hSIE and Stat-3 after MHC-I ligation was directly demonstrated by precipitating Stat-3 from nuclear extracts with biotinylated hSIE probe and avidin-coupled agarose.", "output": {"entities": {"gene": [{"text": "hSIE", "start": 23, "end": 27}, {"text": "Stat-3", "start": 32, "end": 38}, {"text": "MHC-I", "start": 45, "end": 50}, {"text": "Stat-3", "start": 103, "end": 109}, {"text": "hSIE", "start": 150, "end": 154}, {"text": "avidin", "start": 165, "end": 171}]}}, "schema": []}
{"input": "Transcriptional repression mediated by LysR-type regulator CatR bound at multiple binding sites.", "output": {"entities": {"gene": [{"text": "LysR-type regulator CatR", "start": 39, "end": 63}]}}, "schema": []}
{"input": "Two of these resulted in increased levels of the alpha subunit, and one caused a substitution of glycine for the aspartic acid residue at position 171, in the N-terminal domain.", "output": {"entities": {}}, "schema": []}
{"input": "These two mRNA species are produced by differential polyadenylation site usage.", "output": {"entities": {}}, "schema": []}
{"input": "Finally, a role for NF-kappaB in preventing apoptosis induced by ER calcium release was demonstrated by data showing that sAPPalpha prevents thapsigargin-induced apoptosis, an effect blocked by kappaB decoy DNA.", "output": {"entities": {"gene": [{"text": "NF-kappaB", "start": 20, "end": 29}, {"text": "sAPPalpha", "start": 122, "end": 131}, {"text": "kappaB", "start": 194, "end": 200}]}}, "schema": []}
{"input": "Many cytokine receptors employ Janus protein tyrosine kinases (Jaks) and signal transducers and activators of transcription (Stats) for nuclear signaling.", "output": {"entities": {"gene": [{"text": "Janus protein tyrosine kinases", "start": 31, "end": 61}, {"text": "Jaks", "start": 63, "end": 67}, {"text": "signal transducers and activators of transcription", "start": 73, "end": 123}, {"text": "Stats", "start": 125, "end": 130}]}}, "schema": []}
{"input": "A site-directed R618K mutation in the Stat5 SH2 domain abolished the phosphorylation by Jak2, while deletion of the C terminus led to Stat5 hyperphosphorylation.", "output": {"entities": {"gene": [{"text": "Stat5 SH2 domain", "start": 38, "end": 54}, {"text": "Jak2", "start": 88, "end": 92}, {"text": "Stat5", "start": 134, "end": 139}]}}, "schema": []}
{"input": "Specifically, recombination at HMR was used to produce rings that lacked the E and I silencers.", "output": {"entities": {"gene": [{"text": "HMR", "start": 31, "end": 34}]}}, "schema": []}
{"input": "In angiodysplasia, ectatic vessels in the mucosa appeared to contain less collagen type IV than similarly sized vessels in the submucosa, and perforating vessels appeared in many cases to lose staining at the level of the muscularis mucosae.", "output": {"entities": {"gene": [{"text": "collagen type IV", "start": 74, "end": 90}]}}, "schema": []}
{"input": "We studied the human vestibulo-ocular reflex (VOR) in response to head' impulses': brief, unpredictable, passive, high-acceleration (up to 4000 degrees/s2), low-amplitude (20-30 degrees) head rotations.", "output": {"entities": {}}, "schema": []}
{"input": "To clarify whether seizure-offset patterns are reliable in predicting seizure outcome, we studied SEEG/ECoG in a similar group of patients with temporal lobe epilepsy (TLE).", "output": {"entities": {}}, "schema": []}
{"input": "In this study, to characterize the gene for protein Z, its organization and structure were determined by a combination of PCR amplification of leukocyte DNA and isolation of phage clones from a human genomic library.", "output": {"entities": {"gene": [{"text": "protein Z", "start": 44, "end": 53}]}}, "schema": []}
{"input": "These modifications may improve the interlaboratory reproducibility of CD34 determinations due to the reduction in sample handling and calculation of results.", "output": {"entities": {"gene": [{"text": "CD34", "start": 71, "end": 75}]}}, "schema": []}
{"input": "The present results demonstrate that rats with relatively small remnants of one olfactory bulb can perform a variety of odor detection and discrimination tasks as well or nearly as well as controls.", "output": {"entities": {}}, "schema": []}
{"input": "These patients failed to respond to intravenous cyclophosphamide and steroids and were then changed to receive oral cyclosporine A, at a dose of 5 mg/kg/day.", "output": {"entities": {}}, "schema": []}
{"input": "The predicted amino acid sequence is 78. 0% identical to the cytoplasmic dynein heavy chain of Neurospora crassa, 70. 2% identical to that of Aspergillus nidulans and 24. 8% identical to that of Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "cytoplasmic dynein heavy chain of Neurospora crassa", "start": 61, "end": 112}]}}, "schema": []}
{"input": "The DNA binding activities of the three repressor preparations were studied using fragments containing CIRs (CIR3-CIR6) from the essential early region as templates for DNase I footprinting.", "output": {"entities": {"gene": [{"text": "DNase I", "start": 169, "end": 176}]}}, "schema": []}
{"input": "Molecular modelling suggested that the tetramerization domain was a four-helix bundle, stabilized by interactions of seven conserved aromatic amino acids.", "output": {"entities": {}}, "schema": []}
{"input": "In the present study, we sought to investigate whether constitutive NF-kappaB activity in chronically HIV-1-infected promonocytic U937 (U9-IIIB) and myeloblastic PLB-985 (PLB-IIIB) cells affects apoptotic signaling.", "output": {"entities": {"gene": [{"text": "NF-kappaB", "start": 68, "end": 77}]}}, "schema": []}
{"input": "To explore the function of human SINA-homologous (Siah) proteins, expression plasmids encoding Siah-1A were transiently transfected into 293 epithelial cells and GM701 fibroblast cells, resulting in growth arrest without induction of apoptosis.", "output": {"entities": {"gene": [{"text": "SINA-homologous (Siah) proteins", "start": 33, "end": 64}, {"text": "Siah-1A", "start": 95, "end": 102}]}}, "schema": []}
{"input": "We have shown previously that GH3 cells transfected with the rat GnRH receptor cDNA (GGH3-1' cells) support the expression of a cotransfected fusion gene composed of 797 base pairs of rat LHbeta gene 5'-flanking sequence and the first 5 base pairs of the 5'-untranslated region fused to a luciferase reporter (-797/+ 5LHbetaLUC) and respond to a GnRH agonist with a 10-fold stimulation of activity.", "output": {"entities": {"gene": [{"text": "rat GnRH receptor cDNA", "start": 61, "end": 83}, {"text": "rat LHbeta gene 5'-flanking sequence", "start": 184, "end": 220}, {"text": "luciferase reporter (-797/+ 5LHbetaLUC)", "start": 289, "end": 328}, {"text": "GnRH", "start": 346, "end": 350}]}}, "schema": []}
{"input": "The 5'-flanking region, from nucleotide-837 to-336, contains TATA and inverted CAAT boxes as well as GATA-1/SP1 erythroid-specific cis-acting regulatory elements.", "output": {"entities": {"gene": [{"text": "GATA-1", "start": 101, "end": 107}, {"text": "SP1", "start": 108, "end": 111}]}}, "schema": []}
{"input": "We established the radiosensitive cell line SX9 from mammary carcinoma cell line FM3A.", "output": {"entities": {}}, "schema": []}
{"input": "Results showed that the mean bond strength of H. T. V. specimens ranged from 9. 6 to 13. 12 kg/cm2, while the mean bond strength of R. T. V. specimens ranged from 0. 36 to 1. 75 kg/cm2.", "output": {"entities": {}}, "schema": []}
{"input": "OBJECTIVES: To measure coagulation factor VIII: coagulant (F. VIII: C) and C1-esterase inhibitor (C1-INH), hemostasis-associated acute-phase reactant proteins and coagulation factors VII (F. VII), IX (F. IX), and X (F. X), hemostasis proteins not associated with an acute-phase response, in a select population of horses with colic and hemostasis abnormalities, and presumed to have acute-phase changes.", "output": {"entities": {"gene": [{"text": "coagulation factor VIII: coagulant", "start": 23, "end": 57}, {"text": "F. VIII: C", "start": 59, "end": 69}, {"text": "C1-esterase inhibitor", "start": 75, "end": 96}, {"text": "C1-INH", "start": 98, "end": 104}, {"text": "coagulation factors VII", "start": 163, "end": 186}, {"text": "F. VII", "start": 188, "end": 194}, {"text": "F. IX", "start": 201, "end": 206}, {"text": "F. X", "start": 216, "end": 220}]}}, "schema": []}
{"input": "RESULTS: Horses with colic had significantly higher fibrinogen concentration, greater alpha 2AP and protein C activities, and longer PT and APTT than did healthy horses.", "output": {"entities": {"gene": [{"text": "fibrinogen", "start": 52, "end": 62}, {"text": "alpha 2AP", "start": 86, "end": 95}, {"text": "protein C", "start": 100, "end": 109}]}}, "schema": []}
{"input": "The data suggest that plasminogen, alpha 2AP, and C1-INH, should be considered equine acute-phase proteins.", "output": {"entities": {"gene": [{"text": "plasminogen", "start": 22, "end": 33}, {"text": "alpha 2AP", "start": 35, "end": 44}, {"text": "C1-INH", "start": 50, "end": 56}]}}, "schema": []}
{"input": "None of the patients was obese.", "output": {"entities": {}}, "schema": []}
{"input": "Marked elevation of creatine kinase was observed while serum albumin, immunoglobulin, and complement were decreased.", "output": {"entities": {"gene": [{"text": "creatine kinase", "start": 20, "end": 35}, {"text": "albumin", "start": 61, "end": 68}, {"text": "immunoglobulin", "start": 70, "end": 84}]}}, "schema": []}
{"input": "DESIGN AND METHODS: Case study.", "output": {"entities": {}}, "schema": []}
{"input": "METHODS: A total of 15 pigs were randomised to ligation of left marginal arteries (infarction group, n = 5), to TMLR of the left lateral wall using a holmium: yttrium-aluminium garnet (Ho: YAG) laser (laser group, n = 5), and to both (laser-infarction group, n = 5).", "output": {"entities": {}}, "schema": []}
{"input": "RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells.", "output": {"entities": {"gene": [{"text": "RACK1", "start": 0, "end": 5}, {"text": "activated C kinase", "start": 22, "end": 40}, {"text": "G proteins", "start": 78, "end": 88}, {"text": "src tyrosine kinases", "start": 111, "end": 131}]}}, "schema": []}
{"input": "Peptide sequences of the zinc finger protein Ttk and the transcription factor Adf-1 were obtained.", "output": {"entities": {"gene": [{"text": "zinc finger protein Ttk", "start": 25, "end": 48}, {"text": "transcription factor Adf-1", "start": 57, "end": 83}]}}, "schema": []}
{"input": "The same IL-4-inducible reporter gene is also synergistically activated by the endogenous Stat6 and NF-kappaB proteins in IL-4-stimulated I. 29mu B lymphoma cells.", "output": {"entities": {"gene": [{"text": "IL-4", "start": 9, "end": 13}, {"text": "endogenous Stat6", "start": 79, "end": 95}, {"text": "NF-kappaB proteins", "start": 100, "end": 118}, {"text": "IL-4", "start": 122, "end": 126}]}}, "schema": []}
{"input": "HEF1, p130 (Cas), and Efs/Sin constitute a family of multidomain docking proteins that have been implicated in coordinating the regulation of cell adhesion.", "output": {"entities": {"gene": [{"text": "HEF1", "start": 0, "end": 4}, {"text": "p130", "start": 6, "end": 10}, {"text": "Cas", "start": 12, "end": 15}, {"text": "Efs", "start": 22, "end": 25}, {"text": "Sin", "start": 26, "end": 29}]}}, "schema": []}
{"input": "In support of a role at the spindle, two-hybrid library screening with HEF1 identifies the human homolog of the G2/M spindle-regulatory protein Dim1p as a specific interactor with a region of HEF1 encompassed in p55 (HEF1).", "output": {"entities": {"gene": [{"text": "HEF1", "start": 71, "end": 75}, {"text": "G2/M spindle-regulatory protein Dim1p", "start": 112, "end": 149}, {"text": "HEF1", "start": 192, "end": 196}, {"text": "p55", "start": 212, "end": 215}, {"text": "HEF1", "start": 217, "end": 221}]}}, "schema": []}
{"input": "Our data showed that activation of the raf-ERK pathway led to activation of TF expression in breast carcinoma cells and suggested that constitutive activation of this pathway leads to high TF expression in MDA-MB-231 cells.", "output": {"entities": {"gene": [{"text": "raf", "start": 39, "end": 42}, {"text": "ERK", "start": 43, "end": 46}, {"text": "TF", "start": 76, "end": 78}, {"text": "TF", "start": 189, "end": 191}]}}, "schema": []}
{"input": "However, a zinc-depleted enzyme was obtained after prolonged dialysis against the specific chelating agent 1, 10-phenanthroline.", "output": {"entities": {}}, "schema": []}
{"input": "The lines also differed in postsynaptic, but not presynaptic, 5-HT1A receptors.", "output": {"entities": {"gene": [{"text": "5-HT1A receptors", "start": 62, "end": 78}]}}, "schema": []}
{"input": "Convulsive seizure during a treatment with interferon alpha for chronic viral hepatitis C", "output": {"entities": {"gene": [{"text": "interferon alpha", "start": 43, "end": 59}]}}, "schema": []}
{"input": "Genetic studies in Drosophila have led to the identification of several components of the Notch pathway.", "output": {"entities": {"gene": [{"text": "Notch", "start": 90, "end": 95}]}}, "schema": []}
{"input": "The bZP2 cDNA (115-1914 nt, 1. 8 kb), excluding sequences coding for N-terminal signal sequence and C-terminal transmembranelike domain, was PCR amplified and Sac1-Sal1 restricted fragment cloned in frame downstream of the T5 promoter under the lac operator control in a pQE-30 vector.", "output": {"entities": {"gene": [{"text": "bZP2 cDNA (115-1914 nt, 1. 8 kb)", "start": 4, "end": 36}, {"text": "Sac1", "start": 159, "end": 163}, {"text": "Sal1", "start": 164, "end": 168}, {"text": "lac operator", "start": 245, "end": 257}]}}, "schema": []}
{"input": "Control subjects' evoked potentials (EPs) were characterized by an initial positivity in the 90-140 ms range (P1) at the temporo-occipital site.", "output": {"entities": {}}, "schema": []}
{"input": "Class I alpha1, 2-mannosidases play an essential role in the elaboration of complex and hybrid N-glycans in mammalian cells.", "output": {"entities": {"gene": [{"text": "Class I alpha1, 2-mannosidases", "start": 0, "end": 30}]}}, "schema": []}
{"input": "Structural features of the minimal DNA binding domain (M98-F219) of human nucleotide excision repair protein XPA.", "output": {"entities": {"gene": [{"text": "human nucleotide excision repair protein XPA", "start": 68, "end": 112}]}}, "schema": []}
{"input": "Amongst other qualities, the book' s importance lies in the fact that it associates an elaborate theoretical construction with the empirical data, working within the possibilities provided by late 19th-century moral statistics.", "output": {"entities": {}}, "schema": []}
{"input": "The results point to the effectiveness of the educational intervention.", "output": {"entities": {}}, "schema": []}
{"input": "The mechanistic implications of aromatic non-responsiveness of autonomously expressed A-domain, despite its demonstrated ability to bind phenol, are discussed.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: Acetabular index returned to normal gradually as the time went by and significantly within one year after the reduction of developmental dislocation of the hip.", "output": {"entities": {}}, "schema": []}
{"input": "Recently, extremely high levels of endothelin-1 (ET-1) were detected in the pericardial fluid of patients undergoing cardiac surgery.", "output": {"entities": {"gene": [{"text": "endothelin-1", "start": 35, "end": 47}, {"text": "ET-1", "start": 49, "end": 53}]}}, "schema": []}
{"input": "Consequently, it is not known how knee loading changes following ACL transection, and how it contributes to cartilage degeneration.", "output": {"entities": {}}, "schema": []}
{"input": "We show that the surfaces of tracheal cartilage matrix are collagen-rich and surround a proteoglycan-rich core.", "output": {"entities": {"gene": [{"text": "collagen", "start": 59, "end": 67}]}}, "schema": []}
{"input": "Comparative mapping of the Brassica S locus region and its homeolog in Arabidopsis.", "output": {"entities": {"gene": [{"text": "Brassica S locus region", "start": 27, "end": 50}]}}, "schema": []}
{"input": "Roles of the Candida albicans mitogen-activated protein kinase homolog, Cek1p, in hyphal development and systemic candidiasis.", "output": {"entities": {"gene": [{"text": "Candida albicans mitogen-activated protein kinase homolog", "start": 13, "end": 70}, {"text": "Cek1p", "start": 72, "end": 77}]}}, "schema": []}
{"input": "Neither the reaction of monosaccharides nor the disaccharides with beta-alanine resulted in the formation of maltol.", "output": {"entities": {}}, "schema": []}
{"input": "In most subjects, markers of bone formation and resorption were normal.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of a Mac1p mutant, refractile for copper-dependent repression of the Cu (I) transport genes, showed an aberrant pattern of CUP1 expression and copper sensitivity.", "output": {"entities": {"gene": [{"text": "Mac1p mutant", "start": 14, "end": 26}, {"text": "Cu (I) transport genes", "start": 78, "end": 100}, {"text": "CUP1", "start": 132, "end": 136}]}}, "schema": []}
{"input": "The DNA sequencing of the recombinant clones revealed the expression of RXR alpha and RXR beta.", "output": {"entities": {"gene": [{"text": "RXR alpha", "start": 72, "end": 81}, {"text": "RXR beta", "start": 86, "end": 94}]}}, "schema": []}
{"input": "A stratified random sample of 20 active employees from a cohort of phenoxy herbicide workers was selected in 1995 for determining PCDD and PCDF congeners in blood lipids to assess the extent of past PCDD and PCDF exposure in this cohort and whether that exposure might explain site-specific cancer findings in the total cohort.", "output": {"entities": {}}, "schema": []}
{"input": "The clinical and laboratory features of 72 children with Henoch-Schonlein purpura (HSP) were examined to determine if there were associations between the laboratory indices--including white blood cell (WBC) counts, serum C-reactive protein (CRP) levels, platelet (PLT) counts--and the clinical manifestations of acute HSP.", "output": {"entities": {"gene": [{"text": "serum C-reactive protein", "start": 215, "end": 239}, {"text": "CRP", "start": 241, "end": 244}]}}, "schema": []}
{"input": "We provide community metabolic data that indicate that large changes in CO2 concentration can occur in coral reef waters via biogeochemical processes not directly associated with photosynthesis, respiration, calcification, and CaCO3 dissolution.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast to other known retroviruses, the FV pol genes are expressed via spliced transcripts.", "output": {"entities": {"gene": [{"text": "FV pol genes", "start": 45, "end": 57}]}}, "schema": []}
{"input": "Substitution of bulky hydrophobic residues with charged residues within PEP1 affects the fusion activity of the S protein without affecting processing and surface expression.", "output": {"entities": {"gene": [{"text": "PEP1", "start": 72, "end": 76}, {"text": "S protein", "start": 112, "end": 121}]}}, "schema": []}
{"input": "Tributyltin and its breakdown products, mono-and di-butyltin, were determined in water birds collected from Lake Huron (the Great Lakes), marine coastal United States, and the west coast of British Columbia, Canada.", "output": {"entities": {}}, "schema": []}
{"input": "The 5' flanking region of the CD1 gene contained the binding motifs for two cytokine-inducible transcription factors, NF-IL2-A and NF-IL6.", "output": {"entities": {"gene": [{"text": "CD1 gene", "start": 30, "end": 38}, {"text": "NF-IL2-A", "start": 118, "end": 126}, {"text": "NF-IL6", "start": 131, "end": 137}]}}, "schema": []}
{"input": "Fregnac, M.", "output": {"entities": {}}, "schema": []}
{"input": "GLRaV-2 is the only closterovirus, so far, that matches the genome organization of the type member of the group, BYV, and thus can be unambiguously classified as a definitive member of the genus Closterovirus.", "output": {"entities": {}}, "schema": []}
{"input": "Demographic and clinical data were compared with a control group of 339 healthy age-matched women and with a sample of 224 women with wrist fracture.", "output": {"entities": {}}, "schema": []}
{"input": "Identical results were obtained when transfections and mobility shift assays were performed in primary rat hepatocytes in which the endogenous ALS gene is expressed.", "output": {"entities": {"gene": [{"text": "ALS gene", "start": 143, "end": 151}]}}, "schema": []}
{"input": "This E box sequence (CACGTG) is identical to the binding element for USF (upstream stimulatory factor), a member of the helix-loop-helix family of transcription factors.", "output": {"entities": {"gene": [{"text": "USF", "start": 69, "end": 72}, {"text": "upstream stimulatory factor", "start": 74, "end": 101}, {"text": "helix-loop-helix family of transcription factors", "start": 120, "end": 168}]}}, "schema": []}
{"input": "Interferon beta therapy was discontinued for 4 weeks.", "output": {"entities": {"gene": [{"text": "Interferon beta", "start": 0, "end": 15}]}}, "schema": []}
{"input": "We specially devised 3 types of turbo pumps, a centrifugal pump (CFP), a mixed flow pump (MFP), and an axial flow pump (AFP), and analyzed their in vitro performance.", "output": {"entities": {}}, "schema": []}
{"input": "Examination of the mitochondrial bc1 complex crystal structure [Zhang, Z., Huang, L., Shulmeister, V.", "output": {"entities": {"gene": [{"text": "mitochondrial bc1 complex crystal structure", "start": 19, "end": 62}]}}, "schema": []}
{"input": "Two protease-resistant fragments spanning the N-and C-terminal halves of the nuclease were identified using different proteases which cleave the protein in the same region.", "output": {"entities": {}}, "schema": []}
{"input": "The side-to-side difference was statistically significant at EXT 30 degrees/s and 60 degrees/s (p < 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSION: In women who want or require conservative management of grade 4 prolapse and are unable to retain a single pessary, the placement of two pessaries often will be successful.", "output": {"entities": {}}, "schema": []}
{"input": "Rev-erbAalpha/beta), Mxi-1 and Mad bHLH-zip proteins and the oncoproteins PLZF and LAZ3/BCL6 is mediated by the corepressors N-CoR and SMRT.", "output": {"entities": {"gene": [{"text": "Rev", "start": 0, "end": 3}, {"text": "erbAalpha/beta", "start": 4, "end": 18}, {"text": "Mxi-1", "start": 21, "end": 26}, {"text": "Mad", "start": 31, "end": 34}, {"text": "PLZF", "start": 74, "end": 78}, {"text": "LAZ3", "start": 83, "end": 87}, {"text": "BCL6", "start": 88, "end": 92}, {"text": "N-CoR", "start": 125, "end": 130}, {"text": "SMRT", "start": 135, "end": 139}]}}, "schema": []}
{"input": "The ParaSight-F test alone was used to monitor serum antigen levels after treatment in 24 patients.", "output": {"entities": {}}, "schema": []}
{"input": "The purified recombinant protein was assayed for its enzyme activity by monitoring transfer of [3H] methyl groups from the substrate DNA to the MGMT protein; the activity was found to be stable at 90 degrees C for at least 30 min.", "output": {"entities": {"gene": [{"text": "MGMT protein", "start": 144, "end": 156}]}}, "schema": []}
{"input": "A deproteinization procedure was coupled with a reversed-phase HPLC separation using a 250x4. 6 mm I. D.", "output": {"entities": {}}, "schema": []}
{"input": "Elimination of the inducible response requires simultaneous mutation of both sequences, however, in the presence of an intact EpRE the upstream AP-1 site is irrelevant to induction.", "output": {"entities": {"gene": [{"text": "AP-1 site", "start": 144, "end": 153}]}}, "schema": []}
{"input": "Three high mobility group-like sequences within a 48-base pair enhancer of the Col2a1 gene are required for cartilage-specific expression in vivo.", "output": {"entities": {"gene": [{"text": "high mobility group-like sequences", "start": 6, "end": 40}, {"text": "Col2a1 gene", "start": 79, "end": 90}]}}, "schema": []}
{"input": "The sequence contains an open reading frame of 1744 nt in the virus-sense strand, a 3' untranslated region of 1360 nt and a 3' poly (A) tail.", "output": {"entities": {}}, "schema": []}
{"input": "A phylogenetic analysis of the reverse transcriptase domain confirms our differential genetic assessment that Cyclops from pea is a novel element with no specific relationship to the previously described Gypsy-like elements from plants.", "output": {"entities": {"gene": [{"text": "reverse transcriptase domain", "start": 31, "end": 59}, {"text": "Cyclops", "start": 110, "end": 117}, {"text": "Gypsy-like elements", "start": 204, "end": 223}]}}, "schema": []}
{"input": "At physiological doses, either insulin-like growth factor I (IGF-I) or insulin turned out to be as potent as dibutyryl cAMP (dbcAMP) in increasing UCP1 gene transcription rate (1 h) and also UCP1 mRNA accumulation (3 h), their maximal effect (15-fold increase) reached upon treatment for 24 h.", "output": {"entities": {"gene": [{"text": "insulin-like growth factor I", "start": 31, "end": 59}, {"text": "IGF-I", "start": 61, "end": 66}, {"text": "insulin", "start": 71, "end": 78}, {"text": "UCP1 gene", "start": 147, "end": 156}, {"text": "UCP1 mRNA", "start": 191, "end": 200}]}}, "schema": []}
{"input": "In addition, insulin induced AP-1 DNA binding activity, this effect being totally prevented in the presence of MEK-1 inhibitor.", "output": {"entities": {"gene": [{"text": "insulin", "start": 13, "end": 20}, {"text": "AP-1", "start": 29, "end": 33}, {"text": "MEK-1", "start": 111, "end": 116}]}}, "schema": []}
{"input": "Essentially, 2'-O-methyl oligoribonucleotides (2' OMeRNA) were delivered to the nuclei of primary mdx myoblasts in culture.", "output": {"entities": {}}, "schema": []}
{"input": "Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.", "output": {"entities": {"gene": [{"text": "p21", "start": 24, "end": 27}, {"text": "WAF1", "start": 28, "end": 32}, {"text": "Cip1", "start": 33, "end": 37}, {"text": "Sp1", "start": 99, "end": 102}, {"text": "Smad family members", "start": 107, "end": 126}]}}, "schema": []}
{"input": "RESULTS: We isolated a C. elegans cDNA that encoded a protein which was similar to, but not exactly homologous with mammalian p120 Ras-GAP.", "output": {"entities": {"gene": [{"text": "p120 Ras", "start": 126, "end": 134}, {"text": "GAP", "start": 135, "end": 138}]}}, "schema": []}
{"input": "The weak base ketoconazole showed complete dissolution from a tablet formulation in Simulated Gastric Fluid without pepsin (SGFsp) within 30 minutes, 70% dissolution in 2 hours under fed state simulated upper jejunal conditions but only 6% dissolution in 2 hours under fasted state conditions.", "output": {"entities": {"gene": [{"text": "pepsin", "start": 116, "end": 122}]}}, "schema": []}
{"input": "In mammals, the Rb protein interacts specifically with D-type cyclins and regulates cell proliferation by binding and inhibiting E2F transcription factors.", "output": {"entities": {"gene": [{"text": "Rb protein", "start": 16, "end": 26}, {"text": "D-type cyclins", "start": 55, "end": 69}, {"text": "E2F transcription factors", "start": 129, "end": 154}]}}, "schema": []}
{"input": "In addition to the signals obtained by ligation of the TCR, T cells need additional, co-stimulatory signals to be activated.", "output": {"entities": {"gene": [{"text": "TCR", "start": 55, "end": 58}]}}, "schema": []}
{"input": "Moreover, the observation of enhanced luteal HSP-27 phosphorylation in vivo, in late pregnancy, when PKC-delta is abundant and active, suggests that select PKC family members contribute to sHSP phosphorylation events in vivo.", "output": {"entities": {"gene": [{"text": "luteal HSP-27", "start": 38, "end": 51}, {"text": "PKC-delta", "start": 101, "end": 110}, {"text": "PKC family members", "start": 156, "end": 174}, {"text": "sHSP", "start": 189, "end": 193}]}}, "schema": []}
{"input": "We characterized the structure of this leader mRNA by using the program Mfold and a combination of nested and internal deletions transcriptionally fused to a promoterless lac operon.", "output": {"entities": {"gene": [{"text": "lac operon", "start": 171, "end": 181}]}}, "schema": []}
{"input": "The importance of these sites for transcriptional activation was studied by site-directed mutagenesis followed by promoter function analysis of the mutants with a chloramphenicol acetyltransferase reporter system.", "output": {"entities": {"gene": [{"text": "chloramphenicol acetyltransferase reporter", "start": 163, "end": 205}]}}, "schema": []}
{"input": "Routine blood examination showed leukocytosis, thrombocytopenia, positive CRP, and elevated myocardial enzymes.", "output": {"entities": {"gene": [{"text": "CRP", "start": 74, "end": 77}]}}, "schema": []}
{"input": "Previous studies have suggested that moderate cooling increases the responsiveness of vascular alpha2-adrenoceptors.", "output": {"entities": {"gene": [{"text": "vascular alpha2-adrenoceptors", "start": 86, "end": 115}]}}, "schema": []}
{"input": "Two members of the Cbl family have since been defined in mammals (c-Cbl and Cbl-b), one in C. elegans (Sli-1) and one in Drosophila (D-Cbl).", "output": {"entities": {"gene": [{"text": "Cbl family", "start": 19, "end": 29}, {"text": "c-Cbl", "start": 66, "end": 71}, {"text": "Cbl-b", "start": 76, "end": 81}, {"text": "Sli-1", "start": 103, "end": 108}, {"text": "D-Cbl", "start": 133, "end": 138}]}}, "schema": []}
{"input": "Anti-PTB antibodies did not inhibit the binding of PTB to RNA because they were able to supershift RNA-PTB complexes.", "output": {"entities": {"gene": [{"text": "Anti-PTB antibodies", "start": 0, "end": 19}, {"text": "PTB", "start": 51, "end": 54}, {"text": "RNA-PTB complexes", "start": 99, "end": 116}]}}, "schema": []}
{"input": "The use of antibodies to the polypyrimidine tract binding protein (PTB) to analyze the protein components that assemble on alternatively spliced pre-mRNAs that use distant branch points.", "output": {"entities": {"gene": [{"text": "polypyrimidine tract binding protein", "start": 29, "end": 65}, {"text": "PTB", "start": 67, "end": 70}]}}, "schema": []}
{"input": "The therapeutic use of botulinum toxin (Botox) is increasing in popularity.", "output": {"entities": {"gene": [{"text": "botulinum toxin", "start": 23, "end": 38}, {"text": "Botox", "start": 40, "end": 45}]}}, "schema": []}
{"input": "The viral oncoprotein E1A inhibits NFAT-dependent transactivation in a p300-dependent manner.", "output": {"entities": {"gene": [{"text": "viral oncoprotein E1A", "start": 4, "end": 25}, {"text": "NFAT", "start": 35, "end": 39}, {"text": "p300", "start": 71, "end": 75}]}}, "schema": []}
{"input": "We have applied the mRNA differential display method to compare and analyze mRNAs prepared from five normal nasopharyngeal epithelial cell cultures and five nasopharyngeal carcinoma cell lines.", "output": {"entities": {}}, "schema": []}
{"input": "Similar experiments with TR support the high affinity of RIP140 to the RXR subunit and also suggest that either partner in the TR/RXR heterodimer can independently respond to ligand.", "output": {"entities": {"gene": [{"text": "TR", "start": 25, "end": 27}, {"text": "RIP140", "start": 57, "end": 63}, {"text": "RXR subunit", "start": 71, "end": 82}, {"text": "TR", "start": 127, "end": 129}, {"text": "RXR", "start": 130, "end": 133}]}}, "schema": []}
{"input": "SETTING: University hospital-based, tertiary care infertility center.", "output": {"entities": {}}, "schema": []}
{"input": "RESULT (S): In patients with elevated FSH levels on cycle day 3, a low oocyte yield was achieved (7 versus 11) and a high number of ampules of hMG was necessary (56 versus 33).", "output": {"entities": {"gene": [{"text": "FSH", "start": 38, "end": 41}, {"text": "hMG", "start": 143, "end": 146}]}}, "schema": []}
{"input": "RESULTS: Of the patients with IS, 67% had significantly greater values of directional preponderance on the OVAR test (a measure of otolith system imbalance) compared with control subjects.", "output": {"entities": {}}, "schema": []}
{"input": "In the ePTFE specimens, tissue coverage had increased.", "output": {"entities": {}}, "schema": []}
{"input": "As predicted by the Wing and Kristofferson model, the durations of successive ISIs tended to be negatively correlated.", "output": {"entities": {}}, "schema": []}
{"input": "We found the following: Specific mutations affected the precise carbohydrate structure and folding of the HA trimer.", "output": {"entities": {"gene": [{"text": "HA trimer", "start": 106, "end": 115}]}}, "schema": []}
{"input": "The results show that ROS production by viable spermatozoa is highly correlated with the concentration of PMN elastase and the number of both peroxidase-positive and round cells.", "output": {"entities": {"gene": [{"text": "PMN elastase", "start": 106, "end": 118}, {"text": "peroxidase", "start": 142, "end": 152}]}}, "schema": []}
{"input": "Yeast U1 snRNP is considerably more complex than its metazoan counterpart, which suggests possible differences between yeast and metazoa in early splicing events.", "output": {"entities": {"gene": [{"text": "Yeast U1 snRNP", "start": 0, "end": 14}]}}, "schema": []}
{"input": "Yeast U1 snRNP therefore contains 16 different proteins, including seven snRNP core proteins, three homologues of the metazoan U1 snRNP-specific proteins, and six yeast-specific U1 snRNP proteins.", "output": {"entities": {"gene": [{"text": "Yeast U1 snRNP", "start": 0, "end": 14}, {"text": "snRNP core proteins", "start": 73, "end": 92}, {"text": "metazoan U1 snRNP-specific proteins", "start": 118, "end": 153}, {"text": "yeast-specific U1 snRNP proteins", "start": 163, "end": 195}]}}, "schema": []}
{"input": "After the first cycle, 18 cases were treated at dose level 1, after a second cycle, 13 cases were treated at dose level 2.", "output": {"entities": {}}, "schema": []}
{"input": "The opioid antagonist naltrexone (0. 01-1. 0 mg/kg) antagonized the discriminative stimulus effects of heroin, but naltrexone at doses up to 10 mg/kg had no effect on the discriminative stimulus effects of cocaine.", "output": {"entities": {}}, "schema": []}
{"input": "In this study we examined hepatic stellate cell regulation of M6P/IGFIIR expression and found that M6P/IGFIIR mRNA transcript levels increased in stellate cells from rats exposed to carbon tetrachloride (CCl4), a potent fibrogenic stimulant.", "output": {"entities": {"gene": [{"text": "M6P", "start": 62, "end": 65}, {"text": "IGFIIR", "start": 66, "end": 72}, {"text": "M6P", "start": 99, "end": 102}, {"text": "IGFIIR", "start": 103, "end": 109}]}}, "schema": []}
{"input": "One cDNA clone designated NCoA-62, encoded a 62, 000-Da protein that is highly related to BX42, a Drosophila melanogaster nuclear protein involved in ecdysone-stimulated gene expression.", "output": {"entities": {"gene": [{"text": "BX42", "start": 90, "end": 94}]}}, "schema": []}
{"input": "These widely expressed proteins share a C-terminal region that bears significant sequence homology to a group of GDP/GTP exchange proteins for the Rab3 family of small GTP binding proteins.", "output": {"entities": {"gene": [{"text": "GDP/GTP exchange proteins", "start": 113, "end": 138}, {"text": "Rab3 family", "start": 147, "end": 158}, {"text": "small GTP binding proteins", "start": 162, "end": 188}]}}, "schema": []}
{"input": "Whereas p82 expression had no effect on ERK2 activation by p126, p70 completely abrogated this activity.", "output": {"entities": {"gene": [{"text": "p82", "start": 8, "end": 11}, {"text": "ERK2", "start": 40, "end": 44}, {"text": "p126", "start": 59, "end": 63}, {"text": "p70", "start": 65, "end": 68}]}}, "schema": []}
{"input": "The pre-mRNA splicing factor U2AF (U2 small nuclear ribonucleoprotein particle [snRNP] auxiliary factor) plays a critical role in 3' splice site selection.", "output": {"entities": {"gene": [{"text": "U2AF", "start": 29, "end": 33}, {"text": "U2 small nuclear ribonucleoprotein particle [snRNP] auxiliary factor", "start": 35, "end": 103}]}}, "schema": []}
{"input": "The brackets were bonded to 100 freshly extracted bovine incisors, and, after storage in tap water at room temperature for 24 hours, they were subsequently tested in a shear mode using a universal testing machine.", "output": {"entities": {}}, "schema": []}
{"input": "Exercise training has become increasingly important in the treatment of heart failure patients.", "output": {"entities": {}}, "schema": []}
{"input": "The growth of Aer. hydrophila in filter-sterilized lettuce extract was completely inhibited by 0. 1% (v/v) BMC whereas that of Ps. fluorescens was not significantly affected by 1% (v/v) BMC.", "output": {"entities": {}}, "schema": []}
{"input": "Despite continuous compliance, unexplained resurgence of serum ferritin levels occurred in 4/7 patients of the' veteran' group after 4-5 years on L1.", "output": {"entities": {"gene": [{"text": "ferritin", "start": 63, "end": 71}]}}, "schema": []}
{"input": "Hematocrit and PaO2 did not change.", "output": {"entities": {}}, "schema": []}
{"input": "Regulation of myosin phosphatase activity involves changes in subunit interactions, although molecular mechanisms are not defined.", "output": {"entities": {"gene": [{"text": "myosin phosphatase", "start": 14, "end": 32}]}}, "schema": []}
{"input": "Commutative saccadic generator is sufficient to control a 3-D ocular plant with pulleys.", "output": {"entities": {}}, "schema": []}
{"input": "The virus-associated VAI RNA of adenovirus is a small highly structured RNA that is required for the efficient translation of cellular and viral mRNAs at late times after infection.", "output": {"entities": {"gene": [{"text": "VAI", "start": 21, "end": 24}]}}, "schema": []}
{"input": "Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer.", "output": {"entities": {"gene": [{"text": "cyclin-dependent kinase", "start": 41, "end": 64}, {"text": "p18", "start": 75, "end": 78}]}}, "schema": []}
{"input": "The YccA protein was found to be degraded in an FtsH-dependent manner in vivo and in vitro, whereas the YccA11 mutant protein, lacking eight amino acid residues within the amino-terminal cytoplasmic domain, was refractory to the degradation.", "output": {"entities": {"gene": [{"text": "YccA protein", "start": 4, "end": 16}, {"text": "FtsH", "start": 48, "end": 52}, {"text": "YccA11 mutant protein", "start": 104, "end": 125}]}}, "schema": []}
{"input": "The major type involves activator proteins that bind to DNA adjacent to where the RNA polymerase (RNAP) holoenzyme binds, usually assisting in recruitment of the RNAP to the promoter.", "output": {"entities": {"gene": [{"text": "RNA polymerase", "start": 82, "end": 96}, {"text": "RNAP", "start": 98, "end": 102}, {"text": "RNAP", "start": 162, "end": 166}]}}, "schema": []}
{"input": "A conserved role for L1 as a transmembrane link between neuronal adhesion and membrane cytoskeleton assembly.", "output": {"entities": {"gene": [{"text": "L1", "start": 21, "end": 23}]}}, "schema": []}
{"input": "Atmospheric benzene, urinary muconic acid (tt-MA) and leukocyte alkaline phosphatase activity (LAPA) were evaluated among 66 car mechanics, 34 road tanker drivers, and 28 nonexposed workers.", "output": {"entities": {"gene": [{"text": "leukocyte alkaline phosphatase", "start": 54, "end": 84}]}}, "schema": []}
{"input": "It contains a 5'-noncoding region (NCR) of 73 nucleotides, five open reading frames (ORFs 1 to 5) which encode proteins with M (r) 160 kDa RNA-dependent RNA polymerase (ORF1), 26 kDa movement protein 1 (ORF2), 13 kDa movement protein 2 (ORF3), 10 kDa movement protein 3 (ORF4), 24 kDa coat protein (OFR5), and a 3' NCR of 76 nucleotides.", "output": {"entities": {"gene": [{"text": "160 kDa RNA-dependent RNA polymerase (ORF1)", "start": 131, "end": 174}, {"text": "26 kDa movement protein 1 (ORF2)", "start": 176, "end": 208}, {"text": "13 kDa movement protein 2 (ORF3)", "start": 210, "end": 242}, {"text": "10 kDa movement protein 3 (ORF4)", "start": 244, "end": 276}, {"text": "24 kDa coat protein (OFR5)", "start": 278, "end": 304}]}}, "schema": []}
{"input": "After profound normovolemic hemodilution (Hct 9%) superiority of LV MC and LV diastolic properties was found, when myocardial oxygenation was supported by i. v. perflubron emulsion, a temporary O2 carrier.", "output": {"entities": {}}, "schema": []}
{"input": "These genes may represent interesting targets for new therapeutic strategies.", "output": {"entities": {}}, "schema": []}
{"input": "It could also inhibit C1q-dependent haemolysis of both IgG-and IgM-sensitized erythrocytes.", "output": {"entities": {"gene": [{"text": "C1q", "start": 22, "end": 25}, {"text": "IgG", "start": 55, "end": 58}, {"text": "IgM", "start": 63, "end": 66}]}}, "schema": []}
{"input": "3) and one distal (-11. 8/-10. 9), presented an enhancer activity in pituitary cells when placed upstream of the SV40 promoter.", "output": {"entities": {"gene": [{"text": "SV40 promoter", "start": 113, "end": 126}]}}, "schema": []}
{"input": "3--It is necessary to think about cosmetic consequences of the chinese flap and consider other possibilities of the flap choice.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSION: TNF alpha, TGF beta, PDGF and IL-1beta increased LDLr gene expression by increasing sterol-independent and mitogenesis-independent gene transcription.", "output": {"entities": {"gene": [{"text": "TNF alpha", "start": 12, "end": 21}, {"text": "TGF beta", "start": 23, "end": 31}, {"text": "PDGF", "start": 33, "end": 37}, {"text": "IL-1beta", "start": 42, "end": 50}, {"text": "LDLr gene", "start": 61, "end": 70}]}}, "schema": []}
{"input": "However, it is only one-half and one-third the size of the proteolipids from M. thermoautotrophicum and M. jannaschii, respectively. ahaK is expressed in Escherichia coli, and it is incorporated into the cytoplasmic membrane despite the different chemical natures of lipids from archaea and bacteria.", "output": {"entities": {"gene": [{"text": "ahaK", "start": 133, "end": 137}]}}, "schema": []}
{"input": "In this report we studied the role of protein-tyrosine phosphatase SHP-2 in ErbB-mediated activation of mitogen-activated protein kinase (MAPK) by overexpressing SHP-2 mutants in COS-7 cells.", "output": {"entities": {"gene": [{"text": "protein-tyrosine phosphatase SHP-2", "start": 38, "end": 72}, {"text": "ErbB", "start": 76, "end": 80}, {"text": "mitogen-activated protein kinase", "start": 104, "end": 136}, {"text": "MAPK", "start": 138, "end": 142}, {"text": "SHP-2 mutants", "start": 162, "end": 175}]}}, "schema": []}
{"input": "Osteoadherin is a recently described bone proteoglycan containing keratan sulfate.", "output": {"entities": {"gene": [{"text": "Osteoadherin", "start": 0, "end": 12}]}}, "schema": []}
{"input": "Intron 8 harbored a strong erythroid-specific enhancer activity which was orientation-dependent.", "output": {"entities": {}}, "schema": []}
{"input": "The intron 8 enhancer region was not activated by GATA-1 together with Sp1 in transactivation experiments in COS-1 cells indicating the involvement of a related Sp1 protein or of another unidentified erythroid factor.", "output": {"entities": {"gene": [{"text": "GATA-1", "start": 50, "end": 56}, {"text": "Sp1", "start": 71, "end": 74}, {"text": "Sp1 protein", "start": 161, "end": 172}]}}, "schema": []}
{"input": "The cleavage of Fak by caspases may thus play an important role in the execution of the suicide program by disabling the anti-apoptotic function of Fak.", "output": {"entities": {"gene": [{"text": "Fak", "start": 16, "end": 19}, {"text": "caspases", "start": 23, "end": 31}, {"text": "Fak", "start": 148, "end": 151}]}}, "schema": []}
{"input": "Moreover, the mass estimated with the QCM response through the Sauerbrey equation and the mass which can be measured thanks to other analytical techniques, in our case an enzymatic assay, are different: the deposited mass is generally overestimated by the QCM.", "output": {"entities": {}}, "schema": []}
{"input": "Transcription initiation occurred predominantly at the putative sigmaA-dependent promoter in exponentially growing cells and was induced under stress conditions.", "output": {"entities": {"gene": [{"text": "sigmaA-dependent promoter", "start": 64, "end": 89}]}}, "schema": []}
{"input": "The genes encoding (2Fe-2S) plant-like ferredoxins were studied in the widely used cyanobacterium Synechocystis PCC6803.", "output": {"entities": {"gene": [{"text": "(2Fe-2S) plant-like ferredoxins", "start": 19, "end": 50}]}}, "schema": []}
{"input": "RNA of GBV-C was detected in 14 (18%) patients before BMT.", "output": {"entities": {}}, "schema": []}
{"input": "A major pool of Dsg-plakoglobin complexes sedimented at 8S and exhibited a 1: 1 stoichiometry.", "output": {"entities": {"gene": [{"text": "Dsg", "start": 16, "end": 19}, {"text": "plakoglobin", "start": 20, "end": 31}]}}, "schema": []}
{"input": "Our results indicate that the binding of CBF/NF-Y to the inverted CCAAT box is responsible for transcriptional activation of the nTPH gene.", "output": {"entities": {"gene": [{"text": "CBF", "start": 41, "end": 44}, {"text": "NF-Y", "start": 45, "end": 49}, {"text": "nTPH gene", "start": 129, "end": 138}]}}, "schema": []}
{"input": "In macrophages, LPS-inducible HIV-1 gene expression is mediated in part by binding of NF-kappa B to identical tandem binding sites located within the long terminal repeat (LTR).", "output": {"entities": {"gene": [{"text": "NF-kappa B", "start": 86, "end": 96}]}}, "schema": []}
{"input": "The influence of p53 on cytokine-triggered Janus kinase-STAT signaling was investigated in human hepatoma Hep3B cell lines engineered to constitutively express the temperature-sensitive Val135 mutant of p53.", "output": {"entities": {"gene": [{"text": "p53", "start": 17, "end": 20}, {"text": "Janus kinase", "start": 43, "end": 55}, {"text": "STAT", "start": 56, "end": 60}, {"text": "Val135 mutant of p53", "start": 186, "end": 206}]}}, "schema": []}
{"input": "It can also be used to examine various laryngeal parameters obtained from videotaped endoscopic and stroboscopic examinations.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS: Two consecutive sets of transrectal ultrasound guided sextant biopsies of the prostate performed in a single office visit represent a cost-effective biopsy strategy for men presenting with an abnormal digital rectal examination and/or elevated serum PSA.", "output": {"entities": {"gene": [{"text": "serum PSA", "start": 257, "end": 266}]}}, "schema": []}
{"input": "Examination of nuclear magnetic resonance (NMR) spectra of a series of N-terminally truncated MIP-1 beta variants reveals that these proteins possess a range of ability to dimerize.", "output": {"entities": {"gene": [{"text": "N-terminally truncated MIP-1 beta variants", "start": 71, "end": 113}]}}, "schema": []}
{"input": "Interestingly, PKA activity is dispensable in a strain lacking Msn2p and Msn4p activity.", "output": {"entities": {"gene": [{"text": "PKA", "start": 15, "end": 18}, {"text": "Msn2p", "start": 63, "end": 68}, {"text": "Msn4p", "start": 73, "end": 78}]}}, "schema": []}
{"input": "They also indicate that direct interactions between C/EBPs and specific Ets family members, together with GATA-1, are important for eosinophil lineage determination.", "output": {"entities": {"gene": [{"text": "C/EBPs", "start": 52, "end": 58}, {"text": "Ets", "start": 72, "end": 75}, {"text": "GATA-1", "start": 106, "end": 112}]}}, "schema": []}
{"input": "Recently, a human transcription elongation factor P-TEFb, consisting of CDK9 kinase, cyclin T and other associated factors, has been shown to interact with Tat to restore Tat activation in HeLa nuclear extract depleted of P-TEFb.", "output": {"entities": {"gene": [{"text": "human transcription elongation factor P-TEFb", "start": 12, "end": 56}, {"text": "CDK9 kinase", "start": 72, "end": 83}, {"text": "cyclin T", "start": 85, "end": 93}, {"text": "Tat", "start": 156, "end": 159}, {"text": "Tat", "start": 171, "end": 174}, {"text": "P-TEFb", "start": 222, "end": 228}]}}, "schema": []}
{"input": "We have used the hydrophobic repeats of the HSF1 trimerization domain in the yeast two-hybrid protein interaction assay to identify heat shock factor binding protein 1 (HSBP1), a novel, conserved, 76-amino-acid protein that contains two extended arrays of hydrophobic repeats that interact with the HSF1 heptad repeats.", "output": {"entities": {"gene": [{"text": "HSF1 trimerization domain", "start": 44, "end": 69}, {"text": "heat shock factor binding protein 1", "start": 132, "end": 167}, {"text": "HSBP1", "start": 169, "end": 174}, {"text": "HSF1 heptad repeats", "start": 299, "end": 318}]}}, "schema": []}
{"input": "Genomic and cDNA clones homologous to the yeast GCN2 eIF-2alpha kinase (yGCN2) were isolated from Drosophila melanogaster.", "output": {"entities": {"gene": [{"text": "GCN2 eIF-2alpha", "start": 48, "end": 63}]}}, "schema": []}
{"input": "The general recombination at a polarizing voltage of 300 V is less than 2% for dose-rates up to about 100 mGy min-1.", "output": {"entities": {}}, "schema": []}
{"input": "The low number of false positives indicates that our scheme would not confuse the radiologist by suggesting normal regions as suspicious.", "output": {"entities": {}}, "schema": []}
{"input": "Strengthening the biological weapons convention and implications on the pharmaceutical and biotechnology industry.", "output": {"entities": {}}, "schema": []}
{"input": "VirD2 is one of the key Agrobacterium tumefaciens proteins involved in T-DNA processing and transfer.", "output": {"entities": {"gene": [{"text": "VirD2", "start": 0, "end": 5}]}}, "schema": []}
{"input": "Taken together, these data indicate that the VirD2 omega domain is important for efficient T-DNA integration.", "output": {"entities": {"gene": [{"text": "VirD2 omega domain", "start": 45, "end": 63}]}}, "schema": []}
{"input": "The DHEAS levels in all stages of decreased BMD were significantly lower than those in the group with normal BMD.", "output": {"entities": {}}, "schema": []}
{"input": "Orientation of the nuclear spin system by optical pumping causes an Overhauser shift of the excitonic energy levels proportional to the degree of nuclear orientation.", "output": {"entities": {}}, "schema": []}
{"input": "Cystatin A, a cysteine proteinase inhibitor, is one of the precursor proteins of cornified cell envelope of keratinocytes and is expressed during the late stage of keratinocyte differentiation.", "output": {"entities": {"gene": [{"text": "Cystatin A", "start": 0, "end": 10}, {"text": "cysteine proteinase", "start": 14, "end": 33}, {"text": "cornified cell envelope", "start": 81, "end": 104}]}}, "schema": []}
{"input": "A role for RalGDS and a novel Ras effector in the Ras-mediated inhibition of skeletal myogenesis.", "output": {"entities": {"gene": [{"text": "RalGDS", "start": 11, "end": 17}, {"text": "Ras", "start": 30, "end": 33}, {"text": "Ras", "start": 50, "end": 53}]}}, "schema": []}
{"input": "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.", "output": {"entities": {"gene": [{"text": "GTPase", "start": 0, "end": 6}, {"text": "RGS12", "start": 33, "end": 38}, {"text": "PDZ", "start": 91, "end": 94}, {"text": "PSD-95", "start": 96, "end": 102}, {"text": "Dlg", "start": 103, "end": 106}, {"text": "ZO-1", "start": 107, "end": 111}]}}, "schema": []}
{"input": "However, mutations in the HNF-4 binding site on element CIIB and inhibition of HNF-4 synthesis in HepG2 cells by antisense HNF-4 constructs decreased the apoCII promoter activity to 25-40% of the control, indicating that HNF-4 is a positive regulator of the apoCII gene.", "output": {"entities": {"gene": [{"text": "HNF-4 binding site", "start": 26, "end": 44}, {"text": "element CIIB", "start": 48, "end": 60}, {"text": "HNF-4", "start": 79, "end": 84}, {"text": "HNF-4 constructs", "start": 123, "end": 139}, {"text": "apoCII promoter", "start": 154, "end": 169}, {"text": "HNF-4", "start": 221, "end": 226}, {"text": "apoCII gene", "start": 258, "end": 269}]}}, "schema": []}
{"input": "272, 19107-19110).", "output": {"entities": {}}, "schema": []}
{"input": "In addition, we find that E2F-1 can cause apoptosis in p53-/-tumour cells and further p300, which also functions as a co-activator for the E2F/DP heterodimer, enhances the apoptotic activity of E2F-1.", "output": {"entities": {"gene": [{"text": "E2F-1", "start": 26, "end": 31}, {"text": "p53-/-", "start": 55, "end": 61}, {"text": "p300", "start": 86, "end": 90}, {"text": "E2F", "start": 139, "end": 142}, {"text": "DP", "start": 143, "end": 145}, {"text": "E2F-1", "start": 194, "end": 199}]}}, "schema": []}
{"input": "Blocked shift/supershift analysis indicates that Fos family member proteins especially Fra-1 and Fra-2 are related to progression and no changes found in the Jun family member proteins although they are present in the AP-1/DNA binding complex.", "output": {"entities": {"gene": [{"text": "Fos family", "start": 49, "end": 59}, {"text": "Fra-1", "start": 87, "end": 92}, {"text": "Fra-2", "start": 97, "end": 102}, {"text": "Jun family", "start": 158, "end": 168}, {"text": "AP-1/DNA binding complex", "start": 218, "end": 242}]}}, "schema": []}
{"input": "Initially, we observed that unmutated p53 is strongly expressed in premalignant mammary glands and in mammary tumors derived from the MMTV-c-myc strain.", "output": {"entities": {"gene": [{"text": "p53", "start": 38, "end": 41}, {"text": "c-myc", "start": 139, "end": 144}]}}, "schema": []}
{"input": "These data show that heterologous virus RNAs (BSMV) can serve as primer donors for MStV mRNA capped RNA-primed transcription in doubly infected plants.", "output": {"entities": {}}, "schema": []}
{"input": "Human isoforms, designated 1 to 4, differ from each other by the start codon used.", "output": {"entities": {}}, "schema": []}
{"input": "Comparison of cDNA and genomic sequences shows that the ZNF189 gene spans approximately 11 kb and is organized into at least four exons, the large 3'-end exon coding for the complete zinc finger domain and the 3' untranslated region.", "output": {"entities": {"gene": [{"text": "ZNF189 gene", "start": 56, "end": 67}]}}, "schema": []}
{"input": "The gp330/Megalin/LRP-2 protein belongs to the low-density lipoprotein receptor gene family and is believed to function as an endocytic receptor for the uptake of lipoproteins and many other ligands.", "output": {"entities": {"gene": [{"text": "gp330", "start": 4, "end": 9}, {"text": "Megalin", "start": 10, "end": 17}, {"text": "LRP-2", "start": 18, "end": 23}, {"text": "low-density lipoprotein receptor gene family", "start": 47, "end": 91}]}}, "schema": []}
{"input": "In the DNA recognition helix of finger II, the conserved Arg at position 62 (N-terminal side of the first zinc-coordinating histidine) was changed to a Leu or Gln.", "output": {"entities": {}}, "schema": []}
{"input": "Dosage in both cases was 0. 2 g/m2.", "output": {"entities": {}}, "schema": []}
{"input": "Five additional copies of Lian elements were isolated, mapped by restriction digestion, and partially sequenced.", "output": {"entities": {"gene": [{"text": "Lian elements", "start": 26, "end": 39}]}}, "schema": []}
{"input": "Evolutionary relationships among putative RNA-dependent RNA polymerases encoded by a mitochondrial virus-like RNA in the Dutch elm disease fungus, Ophiostoma novo-ulmi, by other viruses and virus-like RNAs and by the Arabidopsis mitochondrial genome.", "output": {"entities": {"gene": [{"text": "RNA-dependent RNA polymerases", "start": 42, "end": 71}]}}, "schema": []}
{"input": "Role of the transcription start site core region and transcription factor YY1 in Rous sarcoma virus long terminal repeat promoter activity.", "output": {"entities": {"gene": [{"text": "transcription factor YY1", "start": 53, "end": 77}, {"text": "Rous sarcoma virus long terminal repeat promoter", "start": 81, "end": 129}]}}, "schema": []}
{"input": "Addition of Rap or KN62 after exposure of cells to progesterone agonist Org 2058 had no effect on induction of CAT activity.", "output": {"entities": {"gene": [{"text": "CAT", "start": 111, "end": 114}]}}, "schema": []}
{"input": "The Dax-1 gene encodes a protein that is structurally related to members of the orphan nuclear receptor superfamily.", "output": {"entities": {"gene": [{"text": "Dax-1 gene", "start": 4, "end": 14}, {"text": "orphan nuclear receptor superfamily", "start": 80, "end": 115}]}}, "schema": []}
{"input": "He was administered recombinant IFN alpha-2b under the diagnosis of chronic hepatitis C.", "output": {"entities": {"gene": [{"text": "recombinant IFN alpha-2b", "start": 20, "end": 44}]}}, "schema": []}
{"input": "Regulation at 37 degrees C, therefore, involves the action of three protein kinase cascades that repress HSF1 through phosphorylation of serine residues 303, 307, and 363 and may promote growth by suppressing the heat shock response.", "output": {"entities": {"gene": [{"text": "HSF1", "start": 105, "end": 109}]}}, "schema": []}
{"input": "Clinical implication of protein levels of IL-5 in induced sputum in asthmatic patients.", "output": {"entities": {"gene": [{"text": "IL-5", "start": 42, "end": 46}]}}, "schema": []}
{"input": "In these cells, ras-induced transition is accompanied by a strong induction of AP-1-binding activity along with increased expression of CD44 mRNA and protein.", "output": {"entities": {"gene": [{"text": "ras", "start": 16, "end": 19}, {"text": "AP-1", "start": 79, "end": 83}, {"text": "CD44 mRNA", "start": 136, "end": 145}]}}, "schema": []}
{"input": "This distribution implies that the polycistronic precursor is imported into the nucleolus for processing to the mature snoRNAs, and that the import or processing pathway involves coiled bodies.", "output": {"entities": {}}, "schema": []}
{"input": "Suppressive therapy for thyroid nodules.", "output": {"entities": {}}, "schema": []}
{"input": "Fourteen healthy male volunteers completed the study.", "output": {"entities": {}}, "schema": []}
{"input": "In the absence of Mg2 +, a hydrophobic exonuclease site dominates over the polymerase site for possession of the primer terminus.", "output": {"entities": {}}, "schema": []}
{"input": "As the high-affinity Mg2 + binding sites are filled, the primer terminus migrates from the exonuclease site to a highly based stacked polymerase active site.", "output": {"entities": {}}, "schema": []}
{"input": "One missense allele (P236S) with complete loss of function at 30 degreesC and four missense alleles (L173F, E225K, S269L and E274K) that conferred a temperature sensitive phenotype were identified.", "output": {"entities": {}}, "schema": []}
{"input": "Structural analysis of the 5'-regulatory region reveals that the c-met promoter lacks TATA or CAAT elements but has an extremely high G-C content and multiple Sp1 binding sites.", "output": {"entities": {"gene": [{"text": "c-met promoter", "start": 65, "end": 79}, {"text": "Sp1 binding sites", "start": 159, "end": 176}]}}, "schema": []}
{"input": "The report highlights the possible contribution of stress factors in the context of therapy resistant periodontal disease, and the results seem to be understandable within the context of a stress system disorder perspective.", "output": {"entities": {}}, "schema": []}
{"input": "Acute pancreatitis is a rather common abdominal disorder.", "output": {"entities": {}}, "schema": []}
{"input": "Each binding site, however, was different in its preference for binding partners.", "output": {"entities": {}}, "schema": []}
{"input": "We isolated the human FGF-BP promoter and determined by deletion analysis that TPA regulatory elements were all contained in the first 118 base pairs upstream of the transcription start site.", "output": {"entities": {"gene": [{"text": "human FGF-BP promoter", "start": 16, "end": 37}]}}, "schema": []}
{"input": "Electrophoretic mobility shift assays demonstrated specific nuclear protein binding to-85/-64, and single point mutations suggested important binding nucleotides between-79/-68 with five critical bases between-74/-70 (5'-CTCCT-3').", "output": {"entities": {}}, "schema": []}
{"input": "\" Complex partial \" seizures.", "output": {"entities": {}}, "schema": []}
{"input": "B cell antigen receptor (BCR)-mediated formation of a SHP-2-pp120 complex and its inhibition by Fc gamma RIIB1-BCR coligation.", "output": {"entities": {"gene": [{"text": "B cell antigen receptor", "start": 0, "end": 23}, {"text": "BCR", "start": 25, "end": 28}, {"text": "SHP-2", "start": 54, "end": 59}, {"text": "pp120", "start": 60, "end": 65}, {"text": "Fc gamma RIIB1", "start": 96, "end": 110}, {"text": "BCR", "start": 111, "end": 114}]}}, "schema": []}
{"input": "Chem., 270: 7117-7124, 1995; and MT Hartsough et al., J.", "output": {"entities": {}}, "schema": []}
{"input": "Here we investigate the role of c-Cbl in development and homeostasis in mice by targeted disruption of the c-Cbl locus. c-Cbl-deficient mice were viable, fertile, and outwardly normal in appearance.", "output": {"entities": {"gene": [{"text": "c-Cbl", "start": 32, "end": 37}, {"text": "c-Cbl locus", "start": 107, "end": 118}, {"text": "c-Cbl", "start": 120, "end": 125}]}}, "schema": []}
{"input": "One is to act within the visceral endoderm to promote proper streak morphogenesis.", "output": {"entities": {}}, "schema": []}
{"input": "We propose that noi/pax2. 1 participates in sequential signaling processes as a key integrator of midbrain-hindbrain boundary development.", "output": {"entities": {"gene": [{"text": "noi", "start": 16, "end": 19}, {"text": "pax2. 1", "start": 20, "end": 27}]}}, "schema": []}
{"input": "METHODS: Fibrotic changes involving bone marrow were evaluated histologically semiquantitatively using reticulin fiber impregnation (method of Gomori).", "output": {"entities": {"gene": [{"text": "reticulin", "start": 103, "end": 112}]}}, "schema": []}
{"input": "We then studied four unrelated Japanese families with GSD-Ib, and found three novel mutations: a four-base deletion/two-base insertion, a point mutation within a consensus splicing donor site, and a missense mutation (W118R).", "output": {"entities": {}}, "schema": []}
{"input": "Removal of the carboxyl region severely reduced transcriptional activation.", "output": {"entities": {}}, "schema": []}
{"input": "A \" Level A \" in vitro/in vivo correlation was established for a sustained release theophylline (CAS 58-55-9) preparation (Bronchoretard) under investigation.", "output": {"entities": {}}, "schema": []}
{"input": "METHOD: 50 consecutive children aged from 6 months to 17 years were included into the study which comprised questionnaires of patient and family histories, serological screening tests for common inhalational allergens (CAP SX1), and determination of total serum immunoglobulin E (IgE) and of latex-specific serum IgE by solid-phase immunoassays.", "output": {"entities": {"gene": [{"text": "serum immunoglobulin E", "start": 256, "end": 278}, {"text": "IgE", "start": 280, "end": 283}, {"text": "serum IgE", "start": 307, "end": 316}]}}, "schema": []}
{"input": "The PDE4A-subfamily-specific linker region LR1, which joins UCR1 and UCR2, is encoded by two exons, whereas LR2, which joins UCR2 to the catalytic unit, is encoded by a single exon.", "output": {"entities": {"gene": [{"text": "PDE4A-subfamily-specific linker region", "start": 4, "end": 42}]}}, "schema": []}
{"input": "Pol32Delta strains are weak antimutators and are defective for damage-induced mutagenesis.", "output": {"entities": {"gene": [{"text": "Pol32Delta", "start": 0, "end": 10}]}}, "schema": []}
{"input": "At the same time, the results indicate that p53 plays a defensive role against HBV by transcriptionally repressing the HBV core promoter through liver-specific enhancer II and HBx is required to counteract this inhibitory function of p53.", "output": {"entities": {"gene": [{"text": "p53", "start": 44, "end": 47}, {"text": "HBV core promoter", "start": 119, "end": 136}, {"text": "liver-specific enhancer II", "start": 145, "end": 171}, {"text": "HBx", "start": 176, "end": 179}, {"text": "p53", "start": 234, "end": 237}]}}, "schema": []}
{"input": "To gain insight into the expression of the AtCP1 gene, northern blot analysis was carried out.", "output": {"entities": {"gene": [{"text": "AtCP1 gene", "start": 43, "end": 53}]}}, "schema": []}
{"input": "The aim of the study was to correlate the responsiveness to bronchoprovocation with methacholine in subjects a with allergic rhinitis during and out of the pollen season with total serum IgE and blood eosinophils.", "output": {"entities": {"gene": [{"text": "IgE", "start": 187, "end": 190}]}}, "schema": []}
{"input": "These results provide the first demonstration that an SR protein can influence splicing of specific pre-mRNAs in vivo.", "output": {"entities": {"gene": [{"text": "SR protein", "start": 54, "end": 64}]}}, "schema": []}
{"input": "In particular, the potential for prostate cancer chemoprevention using nonsteroidal anti-inflammatory drugs (cyclo-oxygenase inhibitors; NSAIDs) has received little attention.", "output": {"entities": {"gene": [{"text": "cyclo-oxygenase", "start": 109, "end": 124}]}}, "schema": []}
{"input": "This study reports the isolation of a P. hybrida gene, jaf13, encoding a basic helix-loop-helix protein that, on the basis of sequence homology and intron/exon structure, represents the P. hybrida orthologue of the Z. mays r genes.", "output": {"entities": {"gene": [{"text": "jaf13", "start": 55, "end": 60}, {"text": "basic helix-loop-helix protein", "start": 73, "end": 103}, {"text": "Z. mays r genes", "start": 215, "end": 230}]}}, "schema": []}
{"input": "During the past 4 years, a purposeful search was made for electrocardiograms with documented reversible QRS changes associated with all acute injury pattern.", "output": {"entities": {}}, "schema": []}
{"input": "Mutating a potential cleavage site located N-terminal to the protease domain, Gln2526-Asp2527, diminished processing.", "output": {"entities": {}}, "schema": []}
{"input": "METHODS: Millipore ultrafiltration membranes of three different pore sizes were used as model lenticule materials. The nominal membrane pore sizes were 0. 1 microm, 0. 45 microm, and 3 microm; the surface roughness increased in the same order The membranes were coated with a thin layer of collagen I and implanted in a circular pocket of the anterior cornea of adult cats, and were clinically evaluated for the extent of epithelialization and the persistence of epithelial attachment.", "output": {"entities": {"gene": [{"text": "collagen I", "start": 290, "end": 300}]}}, "schema": []}
{"input": "The role of calcitonin, and other agonists which activate the cAMP pathway, in regulating transcription of the human parathyroid hormone-related protein (PTHrP) gene was investigated in a human lung cancer cell line (BEN).", "output": {"entities": {"gene": [{"text": "calcitonin", "start": 12, "end": 22}, {"text": "human parathyroid hormone-related protein", "start": 111, "end": 152}, {"text": "PTHrP", "start": 154, "end": 159}]}}, "schema": []}
{"input": "The combination of Pitx2 and another homeodomain protein, Pit-1, yielded a synergistic 55-fold activation of the prolactin promoter in transfection assays.", "output": {"entities": {"gene": [{"text": "Pitx2", "start": 19, "end": 24}, {"text": "homeodomain protein", "start": 37, "end": 56}, {"text": "Pit-1", "start": 58, "end": 63}, {"text": "prolactin promoter", "start": 113, "end": 131}]}}, "schema": []}
{"input": "The biochemical and molecular spectrum of ornithine transcarbamylase deficiency.", "output": {"entities": {"gene": [{"text": "ornithine transcarbamylase", "start": 42, "end": 68}]}}, "schema": []}
{"input": "To further understand the role of cis-acting elements in these regulatory mechanisms, we have characterized a transcriptional promoter that drives germline expression of TCR beta gene segments in vivo.", "output": {"entities": {"gene": [{"text": "TCR beta gene segments", "start": 170, "end": 192}]}}, "schema": []}
{"input": "Our results suggest that the crucial role of the mutations activating v-erbA as an oncogene is to' freeze' c-ErbA/TRalpha in its non-liganded, repressive conformation and to facilitate its overexpression.", "output": {"entities": {"gene": [{"text": "v-erbA", "start": 70, "end": 76}, {"text": "c-ErbA", "start": 107, "end": 113}, {"text": "TRalpha", "start": 114, "end": 121}]}}, "schema": []}
{"input": "In this study, we describe a mammalian cell-free transcription system reconstituted with only recombinant proteins and epitope-tagged multiprotein complexes.", "output": {"entities": {}}, "schema": []}
{"input": "This repressor is however unlikely to mediate spi 2. 3 3' UTR silencer action since it was not detected in rat hepatocytes.", "output": {"entities": {"gene": [{"text": "spi 2. 3 3' UTR silencer", "start": 46, "end": 70}]}}, "schema": []}
{"input": "A prerequisite for the synthesis of sialylated glycoconjugates is the activated sugar-nucleotide cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac), which provides a substrate for Golgi sialyltransferases.", "output": {"entities": {"gene": [{"text": "Golgi sialyltransferases", "start": 192, "end": 216}]}}, "schema": []}
{"input": "Thus, the bovine PEDF cDNA isolated here codes for a functional soluble secreted PEDF glycoprotein.", "output": {"entities": {"gene": [{"text": "bovine PEDF cDNA", "start": 10, "end": 26}, {"text": "secreted PEDF glycoprotein", "start": 72, "end": 98}]}}, "schema": []}
{"input": "We found sequences related to this insertion in wild-type strains of N. crassa and other Neurospora species.", "output": {"entities": {}}, "schema": []}
{"input": "When cysteine is scanned through the helices, characteristic repeating patterns of solvent exposure and burial are observed.", "output": {"entities": {}}, "schema": []}
{"input": "Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment.", "output": {"entities": {"gene": [{"text": "Human ULK1", "start": 0, "end": 10}, {"text": "serine/threonine kinase", "start": 20, "end": 43}, {"text": "UNC-51 kinase", "start": 55, "end": 68}]}}, "schema": []}
{"input": "Specifically, I use molecular markers that identify particular neuroectodermal domains, all neuroblasts or individual neuroblasts, to show that in DER mutant embryos (1) intermediate column neuroblasts do not form, (2) medial column neuroblasts often acquire identities inappropriate for their position, while (3) lateral neuroblasts develop normally.", "output": {"entities": {"gene": [{"text": "DER mutant", "start": 147, "end": 157}]}}, "schema": []}
{"input": "Cochlear microphonic potentials in patients with vestibular schwannomas.", "output": {"entities": {}}, "schema": []}
{"input": "These results with clozapine illustrate that LI is sensitive to antipsychotics which differ in their mode of action and furthermore emphasize the value of LI as a test model for detecting the antipsychotic potential of novel drugs.", "output": {"entities": {}}, "schema": []}
{"input": "The complement C3a anaphylatoxin receptor (C3aR) is a seven-transmembrane G-protein coupled chemoattractant receptor that on binding the C3a peptide ligand mediates numerous cellular responses, including histamine release from mast cells. smooth muscle contraction, and the directed migration of eosinophils.", "output": {"entities": {"gene": [{"text": "complement C3a anaphylatoxin receptor", "start": 4, "end": 41}, {"text": "C3aR", "start": 43, "end": 47}, {"text": "seven-transmembrane G-protein coupled chemoattractant receptor", "start": 54, "end": 116}, {"text": "C3a peptide ligand", "start": 137, "end": 155}]}}, "schema": []}
{"input": "CONCLUSIONS: Significant elevations of IL-1alpha and IL-1beta occur in patients with bacterial cystitis and microscopic hematuria.", "output": {"entities": {"gene": [{"text": "IL-1alpha", "start": 39, "end": 48}, {"text": "IL-1beta", "start": 53, "end": 61}]}}, "schema": []}
{"input": "Band-shift assays were performed using the LPS-and IL-1-responsive element (LILRE) oligonucleotide, a gamma interferon activation site-like site that is present in the human IL-1beta promoter.", "output": {"entities": {"gene": [{"text": "LPS-and IL-1-responsive element", "start": 43, "end": 74}, {"text": "LILRE", "start": 76, "end": 81}, {"text": "gamma interferon activation site-like site", "start": 102, "end": 144}, {"text": "human IL-1beta promoter", "start": 168, "end": 191}]}}, "schema": []}
{"input": "The C-terminal region contains the PTP-like domain, whereas the N-terminal region shows no homology to any known mammalian protein.", "output": {"entities": {"gene": [{"text": "PTP-like domain", "start": 35, "end": 50}]}}, "schema": []}
{"input": "In addition, and in support of a mediating role of STATs in the activation of the p21 promoter, overexpression of Stat3 potentiated the cytokine effect on the p21 promoter; whereas a dominant negative Stat3, or a mutation of the STAT response element on the promoter, significantly reduced the cytokine effect.", "output": {"entities": {"gene": [{"text": "STATs", "start": 51, "end": 56}, {"text": "p21 promoter", "start": 82, "end": 94}, {"text": "Stat3", "start": 114, "end": 119}, {"text": "p21 promoter", "start": 159, "end": 171}, {"text": "dominant negative Stat3", "start": 183, "end": 206}, {"text": "STAT response element", "start": 229, "end": 250}]}}, "schema": []}
{"input": "The heterogeneous nuclear ribonucleoprotein C protein tetramer binds U1, U2, and U6 snRNAs through its high affinity RNA binding domain (the bZIP-like motif).", "output": {"entities": {"gene": [{"text": "nuclear ribonucleoprotein C protein tetramer", "start": 18, "end": 62}, {"text": "U1", "start": 69, "end": 71}, {"text": "U2", "start": 73, "end": 75}, {"text": "U6 snRNAs", "start": 81, "end": 90}]}}, "schema": []}
{"input": "On the comparison of correlated proportions for clustered data.", "output": {"entities": {}}, "schema": []}
{"input": "A safe and simple system for the detection of sudden infant death syndrome (SIDS) is proposed.", "output": {"entities": {}}, "schema": []}
{"input": "The resulting mutants were coexpressed with gE in the vaccinia virus-based vTF7-3 system, and the formation and endoplasmic reticulum (ER)-to-Golgi transport of the hetero-oligomeric complex were monitored.", "output": {"entities": {"gene": [{"text": "gE", "start": 44, "end": 46}]}}, "schema": []}
{"input": "Homozygous mutant mice, designated Cux/CDPDeltaCR1, display a phenotype characterized by curly vibrissae and wavy hair.", "output": {"entities": {"gene": [{"text": "Cux", "start": 35, "end": 38}, {"text": "CDPDeltaCR1", "start": 39, "end": 50}]}}, "schema": []}
{"input": "The mutant protein is present at levels slightly greater than wild-type, but exhibits the same tissue distribution as wild-type protein, and has approximately normal affinity for known target sequences (though no DNA targets identified to date require the first cut repeat for binding).", "output": {"entities": {}}, "schema": []}
{"input": "METHODS: We retrospectively reviewed 242 adult cadaveric renal transplant recipients treated between 11/91 and 5/97.", "output": {"entities": {}}, "schema": []}
{"input": "The spectrum of age-associated brain abnormalities: their measurement and histopathological correlates.", "output": {"entities": {}}, "schema": []}
{"input": "Our laboratory has recently identified two phosducin-like orphan proteins (PhLOP1 and PhLOP2) that lack the ability to interact with Gbetagamma.", "output": {"entities": {"gene": [{"text": "phosducin-like orphan proteins", "start": 43, "end": 73}, {"text": "PhLOP1", "start": 75, "end": 81}, {"text": "PhLOP2", "start": 86, "end": 92}, {"text": "Gbetagamma", "start": 133, "end": 143}]}}, "schema": []}
{"input": "Reverse transcriptase-polymerase chain reaction (RT-PCR) was performed using eyestalk complementary DNA of the sand shrimp Metapenaeus ensis.", "output": {"entities": {"gene": [{"text": "Reverse transcriptase", "start": 0, "end": 21}, {"text": "RT", "start": 49, "end": 51}]}}, "schema": []}
{"input": "In contrast, transcription initiating from opuE P-1 (sigma A) rose in proportion to the external osmolarity and was maintained at high levels.", "output": {"entities": {"gene": [{"text": "opuE P-1", "start": 43, "end": 51}, {"text": "sigma A", "start": 53, "end": 60}]}}, "schema": []}
{"input": "Randomly selected 300 children aged 3 months-3 yr were analysed over a period of one year for estimating prevalence of nutritional anaemia.", "output": {"entities": {}}, "schema": []}
{"input": "In insects, arylalkylamine N-acetyltransferases (AANATs) have been implicated in several physiological processes, including sclerotization, inactivation of certain neurotransmitters, and, similar to the function in vertebrates, catalysis of the rate-limiting step in melatonin biosynthesis.", "output": {"entities": {"gene": [{"text": "arylalkylamine N-acetyltransferases", "start": 12, "end": 47}, {"text": "AANATs", "start": 49, "end": 55}]}}, "schema": []}
{"input": "These results establish that hydroquinones lead to mutagenicity and carcinogenicity.", "output": {"entities": {}}, "schema": []}
{"input": "IA-CT with cisplatin 50 mg and doxorubicin 30 mg was administered by one shot method in bilateral internal iliac arteries.", "output": {"entities": {}}, "schema": []}
{"input": "Arnt3 mRNA was expressed in brain, skeletal muscle, 13. 5-day embryos, and P19 cells treated with retinoic acid.", "output": {"entities": {"gene": [{"text": "Arnt3 mRNA", "start": 0, "end": 10}]}}, "schema": []}
{"input": "The genomic structure and chromosomal location of the human TR2 orphan receptor, a member of the steroid receptor superfamily.", "output": {"entities": {"gene": [{"text": "human TR2 orphan receptor", "start": 54, "end": 79}, {"text": "steroid receptor superfamily", "start": 97, "end": 125}]}}, "schema": []}
{"input": "Correlation of skin disorders with CD4 lymphocyte counts in patients with HIV/AIDS.", "output": {"entities": {"gene": [{"text": "CD4", "start": 35, "end": 38}]}}, "schema": []}
{"input": "E2F-6 shares significant homology with E2Fs 1-5, especially within the DNA binding, heterodimerization and marked box domains.", "output": {"entities": {"gene": [{"text": "E2F-6", "start": 0, "end": 5}, {"text": "E2Fs 1-5", "start": 39, "end": 47}]}}, "schema": []}
{"input": "The IE13. 1 cell line was able to complement a recombinant virus in which both copies of the IE gene were replaced by insertion of the Escherichia coli lacZ gene.", "output": {"entities": {"gene": [{"text": "IE gene", "start": 93, "end": 100}, {"text": "Escherichia coli lacZ gene", "start": 135, "end": 161}]}}, "schema": []}
{"input": "DNase I footprinting and electrophoretic mobility shift analyses revealed two hepatocyte nuclear factor-1 (HNF1), three CCAAT/enhancer-binding protein (C/EBP), and one consensus palindromic thyroid hormone response elements within the first 215 base pairs (bp) of the promoter sequence of rat Std.", "output": {"entities": {"gene": [{"text": "DNase I", "start": 0, "end": 7}, {"text": "hepatocyte nuclear factor-1", "start": 78, "end": 105}, {"text": "HNF1", "start": 107, "end": 111}, {"text": "CCAAT/enhancer-binding protein", "start": 120, "end": 150}, {"text": "C/EBP", "start": 152, "end": 157}, {"text": "rat Std", "start": 289, "end": 296}]}}, "schema": []}
{"input": "Thus, these studies on rat Std promoter function indicate that (i) HNF1 and C/EBP are responsible for liver specificity of the rat Std gene; (ii) androgenic repression of the gene requires the presence of all of the OCT-1 and C/EBP elements between positions-231 and-292; and (iii) AR may exert its negative regulatory effect indirectly through transcriptional interference of OCT-1 and C/EBP rather than through a direct DNA-AR interaction.", "output": {"entities": {"gene": [{"text": "rat Std promoter", "start": 23, "end": 39}, {"text": "HNF1", "start": 67, "end": 71}, {"text": "C/EBP", "start": 76, "end": 81}, {"text": "rat Std gene", "start": 127, "end": 139}, {"text": "OCT-1", "start": 216, "end": 221}, {"text": "C/EBP elements", "start": 226, "end": 240}, {"text": "AR", "start": 282, "end": 284}, {"text": "OCT-1", "start": 377, "end": 382}, {"text": "C/EBP", "start": 387, "end": 392}, {"text": "DNA-AR", "start": 422, "end": 428}]}}, "schema": []}
{"input": "Purified Hsk1 phosphorylates the Cdc19 (Mcm2) subunit of the six-member minichromosome maintenance protein complex purified from fission yeast.", "output": {"entities": {"gene": [{"text": "Hsk1", "start": 9, "end": 13}, {"text": "Cdc19", "start": 33, "end": 38}, {"text": "Mcm2", "start": 40, "end": 44}, {"text": "six-member minichromosome maintenance protein complex", "start": 61, "end": 114}]}}, "schema": []}
{"input": "The yeast MMS2 gene was cloned by its ability to complement the methyl methanesulfonate sensitivity of the mms2-1 mutant and was later shown to be involved in DNA post-replication repair.", "output": {"entities": {"gene": [{"text": "yeast MMS2 gene", "start": 4, "end": 19}, {"text": "mms2-1 mutant", "start": 107, "end": 120}]}}, "schema": []}
{"input": "Expression of the human papillomavirus type 11 E5A protein from the E1E4, E5 transcript.", "output": {"entities": {"gene": [{"text": "human papillomavirus type 11 E5A protein", "start": 18, "end": 58}, {"text": "E1E4, E5 transcript", "start": 68, "end": 87}]}}, "schema": []}
{"input": "Anesthesia with M/K was reversed after 41. 6 min of immobilization with atipamezole.", "output": {"entities": {}}, "schema": []}
{"input": "There was no evident inciting agent of the disease.", "output": {"entities": {}}, "schema": []}
{"input": "MK-801 administration resulted in a biphasic response in seizure latency.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast, the distribution of endocytic markers is not affected.", "output": {"entities": {}}, "schema": []}
{"input": "Toxicity during the therapeutic period was not significant in the study group compared with the historical control, treated with the same regimen without G-CSF.", "output": {"entities": {"gene": [{"text": "G-CSF", "start": 154, "end": 159}]}}, "schema": []}
{"input": "Both methods were employed for various focal-film distances, image intensifier tube modes and laser printer formats.", "output": {"entities": {}}, "schema": []}
{"input": "The effect of Rho on AP-1 is independent of the mitogen-activated protein kinase pathway, as a dominant-negative MEK and a MEK inhibitor (PD98059) did not affect Rho-induced AP-1 activity.", "output": {"entities": {"gene": [{"text": "Rho", "start": 14, "end": 17}, {"text": "AP-1", "start": 21, "end": 25}, {"text": "mitogen-activated protein kinase", "start": 48, "end": 80}, {"text": "dominant-negative MEK", "start": 95, "end": 116}, {"text": "MEK", "start": 123, "end": 126}, {"text": "Rho", "start": 162, "end": 165}, {"text": "AP-1", "start": 174, "end": 178}]}}, "schema": []}
{"input": "Site-directed mutagenesis of residues in this domain (R82A, K85A, K88A, and V89A) resulted in proteins which failed to transactivate from the HTLV-1 LTR in vivo.", "output": {"entities": {"gene": [{"text": "HTLV-1 LTR", "start": 142, "end": 152}]}}, "schema": []}
{"input": "Mutations within the C terminus of c-fos at serine residues that are phosphorylation targets for growth factors and MAP kinase completely abrogate transactivation and block potentiation by MAP kinase.", "output": {"entities": {"gene": [{"text": "c-fos", "start": 35, "end": 40}, {"text": "MAP kinase", "start": 116, "end": 126}, {"text": "MAP kinase", "start": 189, "end": 199}]}}, "schema": []}
{"input": "In the former cells, ets-2 was a CSF-1 immediate-early response gene, and phosphorylated ets-2 was detected after 2 to 4 h, coincident with expression of ets-2 protein.", "output": {"entities": {"gene": [{"text": "ets-2", "start": 21, "end": 26}, {"text": "CSF-1", "start": 33, "end": 38}, {"text": "ets-2", "start": 89, "end": 94}, {"text": "ets-2 protein", "start": 154, "end": 167}]}}, "schema": []}
{"input": "Persistent activation of mitogen-activated protein kinases p42 and p44 and ets-2 phosphorylation in response to colony-stimulating factor 1/c-fms signaling.", "output": {"entities": {"gene": [{"text": "mitogen-activated protein kinases p42", "start": 25, "end": 62}, {"text": "p44", "start": 67, "end": 70}, {"text": "ets-2", "start": 75, "end": 80}, {"text": "colony-stimulating factor 1", "start": 112, "end": 139}, {"text": "c-fms", "start": 140, "end": 145}]}}, "schema": []}
{"input": "Identification of a proline-rich sequence in the CD2 cytoplasmic domain critical for regulation of integrin-mediated adhesion and activation of phosphoinositide 3-kinase.", "output": {"entities": {"gene": [{"text": "CD2 cytoplasmic domain", "start": 49, "end": 71}, {"text": "integrin", "start": 99, "end": 107}, {"text": "phosphoinositide 3-kinase", "start": 144, "end": 169}]}}, "schema": []}
{"input": "Vam7p, a SNAP-25-like molecule, and Vam3p, a syntaxin homolog, function together in yeast vacuolar protein trafficking.", "output": {"entities": {"gene": [{"text": "Vam7p", "start": 0, "end": 5}, {"text": "SNAP-25-like molecule", "start": 9, "end": 30}, {"text": "Vam3p", "start": 36, "end": 41}, {"text": "syntaxin homolog", "start": 45, "end": 61}]}}, "schema": []}
{"input": "We have tested this possibility by constructing a consecutive series of cysteine substitutions in the Neu juxtamembrane domain in order to force dimerization along a series of interreceptor faces.", "output": {"entities": {"gene": [{"text": "Neu juxtamembrane domain", "start": 102, "end": 126}]}}, "schema": []}
{"input": "It has been demonstrated previously that Pax-6, a paired domain (PD)/homeodomain (HD) transcription factor critical for eye development, contributes to the activation of the alphaB-, alphaA-, delta1-, and zeta-crystallin genes in the lens.", "output": {"entities": {"gene": [{"text": "Pax-6", "start": 41, "end": 46}, {"text": "paired domain", "start": 50, "end": 63}, {"text": "PD", "start": 65, "end": 67}, {"text": "homeodomain", "start": 69, "end": 80}, {"text": "HD", "start": 82, "end": 84}, {"text": "alphaB-, alphaA-, delta1-, and zeta-crystallin", "start": 174, "end": 220}]}}, "schema": []}
{"input": "Tctex-1 binding required the first 19 amino acids of Fyn and integrity of two lysine residues within this sequence that were previously shown to be important for Fyn interactions with the immunoreceptor tyrosine-based activation motifs (ITAMs) of lymphocyte Ag receptors.", "output": {"entities": {"gene": [{"text": "Tctex-1", "start": 0, "end": 7}, {"text": "Fyn", "start": 53, "end": 56}, {"text": "Fyn", "start": 162, "end": 165}, {"text": "lymphocyte Ag receptors", "start": 247, "end": 270}]}}, "schema": []}
{"input": "The prothrombin gene G20210A mutation is not found among Japanese patients with deep vein thrombosis and healthy individuals.", "output": {"entities": {"gene": [{"text": "prothrombin gene G20210A mutation", "start": 4, "end": 37}]}}, "schema": []}
{"input": "In the studies described in this report, we have investigated the signaling pathway (s) that are responsible for CREB activation in normal T cells.", "output": {"entities": {"gene": [{"text": "CREB", "start": 113, "end": 117}]}}, "schema": []}
{"input": "Respondents who lived with a spouse/partner only were less likely to have an unfavorable BMI status than people in the other two groups.", "output": {"entities": {}}, "schema": []}
{"input": "Isolation of a novel TP53 target gene from a colon cancer cell line carrying a highly regulated wild-type TP53 expression system.", "output": {"entities": {"gene": [{"text": "TP53 target gene", "start": 21, "end": 37}, {"text": "wild-type TP53", "start": 96, "end": 110}]}}, "schema": []}
{"input": "Overexpression of MDR1 has been demonstrated in many cancers, both in patient tumors and in cell lines selected with a variety of chemotherapeutic agents.", "output": {"entities": {"gene": [{"text": "MDR1", "start": 18, "end": 22}]}}, "schema": []}
{"input": "Cytogenetic and molecular characterization of random chromosomal rearrangements activating the drug resistance gene, MDR1/P-glycoprotein, in drug-selected cell lines and patients with drug refractory ALL.", "output": {"entities": {"gene": [{"text": "MDR1", "start": 117, "end": 121}, {"text": "P-glycoprotein", "start": 122, "end": 136}]}}, "schema": []}
{"input": "BACKGROUND: It is generally accepted that smoking increases blood pressure and inhibits muscle sympathetic nerve activity (SNA).", "output": {"entities": {}}, "schema": []}
{"input": "When the blood pressure increase in response to smoking was blunted by nitroprusside infusion, there was a striking increase in muscle SNA.", "output": {"entities": {}}, "schema": []}
{"input": "After that report, carboxypeptidase D (CPD) was subsequently purified from bovine pituitary and characterized as a novel carboxypeptidase E (CPE)-like enzyme, with many characteristics in common with duck gp180 (Song, L., Fricker, L. D., 1995.", "output": {"entities": {"gene": [{"text": "carboxypeptidase D", "start": 19, "end": 37}, {"text": "CPD", "start": 39, "end": 42}, {"text": "carboxypeptidase E", "start": 121, "end": 139}, {"text": "CPE", "start": 141, "end": 144}, {"text": "gp180", "start": 205, "end": 210}]}}, "schema": []}
{"input": "RA-treatment of these transfectants induced morphologic and immunophenotypic maturation, changes in RA-regulated genes, and a G1 cell cycle arrest in a manner similar to parental NT2/D1 cells.", "output": {"entities": {}}, "schema": []}
{"input": "The histopathology and neovascularization did not appreciably differ between xenograft tumors derived from FGF4 over-expressing versus control transfectants.", "output": {"entities": {"gene": [{"text": "FGF4", "start": 107, "end": 111}]}}, "schema": []}
{"input": "For smaller vessels up to a diameter of 0. 5 mm, treatments at 16 and 18 J/cm2 showed good results in 60 and 82% respectively; for vessels up to 1 mm in 27 and 33%.", "output": {"entities": {}}, "schema": []}
{"input": "RXR-gamma expression produced significant reduction in levels of RA-responsive genes including the cyclin-dependent kinase inhibitors p21Cip1/WAF1 and p27Kip1, resulting in increased cdc2 and cdk2 kinase activity and RB phosphorylation.", "output": {"entities": {"gene": [{"text": "RXR-gamma", "start": 0, "end": 9}, {"text": "cyclin-dependent kinase", "start": 99, "end": 122}, {"text": "p21Cip1", "start": 134, "end": 141}, {"text": "WAF1", "start": 142, "end": 146}, {"text": "p27Kip1", "start": 151, "end": 158}, {"text": "cdc2", "start": 183, "end": 187}, {"text": "cdk2 kinase", "start": 192, "end": 203}, {"text": "RB", "start": 217, "end": 219}]}}, "schema": []}
{"input": "Generally ILC and ILVF values decreased with increasing exposure time with rate constants ranging from 0. 03 to 0. 33 day-1 (wet and lipid weight) for ILC and 0. 03 to 0. 31 day-1 for ILVF.", "output": {"entities": {}}, "schema": []}
{"input": "These sequence analyses suggest that xIRS-u is a novel member of the IRS family rather than a Xenopus homolog of an existing member.", "output": {"entities": {"gene": [{"text": "xIRS-u", "start": 37, "end": 43}, {"text": "IRS family", "start": 69, "end": 79}]}}, "schema": []}
{"input": "The present study sought to develop an equation to estimate VO2peak in peripheral arterial occlusive disease (PAOD) patients with intermittent claudication and to determine independent predictors of VO2peak in this population.", "output": {"entities": {}}, "schema": []}
{"input": "The Abbreviated Injury Scale (AIS), Injury Severity Scale and TRISS methodology comprise a mathematically sound system for the analysis of injuries and injured patients.", "output": {"entities": {}}, "schema": []}
{"input": "This hypothesis was tested by introducing mutations at each of the three histidine pairs, the H382-X2-H385 pair, the H411-X2-H414 pair and the H430-X5-H436 pair, which constitute the histidine-rich region near the C terminus of gp17.", "output": {"entities": {"gene": [{"text": "gp17", "start": 228, "end": 232}]}}, "schema": []}
{"input": "Using backcross analysis, both exons 1 and 4 mapped to a proximal region of murine Chromosome 4 indistinguishable from the vacillans gene.", "output": {"entities": {"gene": [{"text": "vacillans gene", "start": 123, "end": 137}]}}, "schema": []}
{"input": "Seventy-five percent of children who received a second transplant for HCV hepatitis had early histologic recurrence that led to liver failure and death.", "output": {"entities": {}}, "schema": []}
{"input": "However, both TPN groups showed a marked increase in activities of liver lysosomal enzymes.", "output": {"entities": {"gene": [{"text": "lysosomal enzymes", "start": 73, "end": 90}]}}, "schema": []}
{"input": "Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr gene.", "output": {"entities": {"gene": [{"text": "Igf2", "start": 72, "end": 76}, {"text": "Mpr", "start": 77, "end": 80}]}}, "schema": []}
{"input": "Furthermore, early-and late-firing origins differ not in the timing of their recruitment of an Mcm protein, but in the timing of RPA' s recruitment.", "output": {"entities": {"gene": [{"text": "Mcm protein", "start": 95, "end": 106}, {"text": "RPA' s", "start": 129, "end": 135}]}}, "schema": []}
{"input": "Thus, in the presence of active S-CDKs and Dbf4/Cdc7, Mcms may open origins and thereby facilitate the loading of RPA.", "output": {"entities": {"gene": [{"text": "active S-CDKs", "start": 25, "end": 38}, {"text": "Dbf4", "start": 43, "end": 47}, {"text": "Cdc7", "start": 48, "end": 52}, {"text": "Mcms", "start": 54, "end": 58}, {"text": "RPA", "start": 114, "end": 117}]}}, "schema": []}
{"input": "Tyrosine phosphorylated STATs dimerize and translocate into the nucleus to activate specific genes.", "output": {"entities": {"gene": [{"text": "STATs", "start": 24, "end": 29}]}}, "schema": []}
{"input": "Nonsynonymous substitution in abalone sperm fertilization genes exceeds substitution in introns and mitochondrial DNA.", "output": {"entities": {}}, "schema": []}
{"input": "Gel retardation assays detected ZiaR-dependent complexes forming with the zia operator-promoter and ZiaR-DNA binding was enhanced by treatment with a metal-chelator in vitro.", "output": {"entities": {"gene": [{"text": "ZiaR", "start": 32, "end": 36}, {"text": "zia operator-promoter", "start": 74, "end": 95}, {"text": "ZiaR", "start": 100, "end": 104}]}}, "schema": []}
{"input": "CONCLUSION: Although quantitative and qualitative criteria for diagnosing fatty liver on helical CT can be determined, they are protocol-specific.", "output": {"entities": {}}, "schema": []}
{"input": "The PC-based RTPS is designed to run in the Microsoft Windows 3. 11 environment (and later versions), for computers equipped with 486 or Pentium processors.", "output": {"entities": {}}, "schema": []}
{"input": "Alternatively, the similarity in apparent regulatory action of the genes may indicate allelic differences wherein the IS1112C Rf3 allele may differ from alleles of maintainer lines by the capability to regulate both orf107 and urf209 processing activities.", "output": {"entities": {"gene": [{"text": "IS1112C Rf3 allele", "start": 118, "end": 136}, {"text": "orf107", "start": 216, "end": 222}, {"text": "urf209", "start": 227, "end": 233}]}}, "schema": []}
{"input": "JCAHO revised interpretation", "output": {"entities": {}}, "schema": []}
{"input": "A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID.", "output": {"entities": {"gene": [{"text": "SPT3", "start": 8, "end": 12}, {"text": "TAFII31", "start": 13, "end": 20}, {"text": "GCN5", "start": 21, "end": 25}, {"text": "L acetylase", "start": 26, "end": 37}, {"text": "transcription factor IID", "start": 60, "end": 84}]}}, "schema": []}
{"input": "Oleate induced steady-state levels of M-CPT I mRNA 4. 5-fold.", "output": {"entities": {"gene": [{"text": "M-CPT I mRNA", "start": 38, "end": 50}]}}, "schema": []}
{"input": "Mapping of the DNA binding domain of the copper-responsive transcription factor Mac1 from Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "Mac1 from Saccharomyces cerevisiae", "start": 80, "end": 114}]}}, "schema": []}
{"input": "A further mechanism increasing specific activation was cooperation of receptors at multiple and weak HREs, which was accentuated in the presence of both the AR N terminus and ligand binding domain.", "output": {"entities": {"gene": [{"text": "AR", "start": 157, "end": 159}]}}, "schema": []}
{"input": "Previously, we characterized a DNA-binding protein, HS2NF5, that bound tightly to a conserved region within hypersensitive site 2 (HS2) of the human beta-globin locus control region (LCR) (Lam, L.", "output": {"entities": {"gene": [{"text": "HS2NF5", "start": 52, "end": 58}, {"text": "human beta-globin locus control region", "start": 143, "end": 181}]}}, "schema": []}
{"input": "The CBF1 site within HS2 resides near sites for hematopoietic regulators such as GATA-1, NF-E2, and TAL1.", "output": {"entities": {"gene": [{"text": "CBF1 site", "start": 4, "end": 13}, {"text": "GATA-1", "start": 81, "end": 87}, {"text": "NF-E2", "start": 89, "end": 94}, {"text": "TAL1", "start": 100, "end": 104}]}}, "schema": []}
{"input": "The rat branched-chain-2-oxo-acid dehydrogenase (BCOD) kinase mRNA is transcribed from a TATA-less promoter that has GC-rich sequences and two putative Sp1 binding sites near the transcription start site.", "output": {"entities": {"gene": [{"text": "rat branched-chain-2-oxo-acid dehydrogenase (BCOD) kinase mRNA", "start": 4, "end": 66}, {"text": "Sp1 binding sites", "start": 152, "end": 169}]}}, "schema": []}
{"input": "Co-transfection of the Sp1 expression plasmid and the-58 promoter construct into Drosophila Schneider cells revealed that Sp1 contributed to the kinase basal promoter activity by binding to the non-consensus site in the-58 region.", "output": {"entities": {"gene": [{"text": "Sp1", "start": 23, "end": 26}, {"text": "Sp1", "start": 122, "end": 125}]}}, "schema": []}
{"input": "Until such investigations are performed, we conclude that the role for adjuvant treatment is questionable and that TME surgery is preferred as the treatment option for Stage T1-T3 rectal cancers.", "output": {"entities": {}}, "schema": []}
{"input": "Likewise, at 150 degrees C with 2% APS the surface density of NH2 groups reached a maximum at 24 hr and remained relatively constant up to 96 hr.", "output": {"entities": {}}, "schema": []}
{"input": "Taken together, these results suggest that the cooperation of transcription factors NF-kappaB and AP-1 is essential for transactivation of IL-8 gene by HTLV-I Tax.", "output": {"entities": {"gene": [{"text": "transcription factors NF-kappaB", "start": 62, "end": 93}, {"text": "AP-1", "start": 98, "end": 102}, {"text": "IL-8 gene", "start": 139, "end": 148}, {"text": "HTLV-I Tax", "start": 152, "end": 162}]}}, "schema": []}
{"input": "This study examines the cooperative effects of a human estrogen receptor-alpha (ERalpha) isoform on estrogen (E2)-mediated gene activation in U2-OS osteosarcoma cells.", "output": {"entities": {"gene": [{"text": "estrogen receptor-alpha", "start": 55, "end": 78}, {"text": "ERalpha", "start": 80, "end": 87}]}}, "schema": []}
{"input": "Transfection of increasing amounts of delta5ERalpha expression vector into [ERalpha +] OS cells resulted in potentiation of E2-stimulated ERELuc activity in a synergistic, dose-dependent manner.", "output": {"entities": {"gene": [{"text": "delta5ERalpha", "start": 38, "end": 51}, {"text": "ERalpha", "start": 76, "end": 83}, {"text": "ERELuc", "start": 138, "end": 144}]}}, "schema": []}
{"input": "Studies using the yeast two-hybrid system also did not provide evidence for the formation of a VDR-TR protein-protein interaction.", "output": {"entities": {"gene": [{"text": "VDR", "start": 95, "end": 98}, {"text": "TR", "start": 99, "end": 101}]}}, "schema": []}
{"input": "We did not observe any changes in Bcl-2 or Bcl-2-related proteins (Bcl-x, Bax, and Bad) in control or KCREB-transfected cells before or after treatment with Tg.", "output": {"entities": {"gene": [{"text": "Bcl-2", "start": 34, "end": 39}, {"text": "Bcl-2-related proteins", "start": 43, "end": 65}, {"text": "Bcl-x", "start": 67, "end": 72}, {"text": "Bax", "start": 74, "end": 77}, {"text": "Bad", "start": 83, "end": 86}, {"text": "KCREB", "start": 102, "end": 107}]}}, "schema": []}
{"input": "Tyrosine 112 of latent membrane protein 2A is essential for protein tyrosine kinase loading and regulation of Epstein-Barr virus latency.", "output": {"entities": {"gene": [{"text": "latent membrane protein 2A", "start": 16, "end": 42}, {"text": "protein tyrosine kinase", "start": 60, "end": 83}]}}, "schema": []}
{"input": "To improve test efficiency, we modified our previously introduced contrast/color card test by including a patterned test stimulus and reducing the number of stimuli in both experimental phases.", "output": {"entities": {}}, "schema": []}
{"input": "The defect in these proteins was also uniformly suppressed by either Mn2 +, or the Mu B protein in the presence of ATP and target DNA.", "output": {"entities": {"gene": [{"text": "Mu B protein", "start": 83, "end": 95}]}}, "schema": []}
{"input": "Using homology cloning techniques, we identified a mouse homologue of E (Pc), termed Epc1, a yeast protein that we name EPL1, and as well as additional ESTs from Caenorhabditis elegans, mice and humans.", "output": {"entities": {"gene": [{"text": "E (Pc)", "start": 70, "end": 76}, {"text": "Epc1", "start": 85, "end": 89}, {"text": "EPL1", "start": 120, "end": 124}]}}, "schema": []}
{"input": "Second, the wild-type m8 3' UTR strongly reduces accumulation of heterologous transcripts in vivo, an activity that requires its K box sequences.", "output": {"entities": {"gene": [{"text": "wild-type m8 3' UTR", "start": 12, "end": 31}]}}, "schema": []}
{"input": "In particular, unc-86 encodes a POU-type homeodomain protein needed for the production of the touch cells, while mec-3 encodes a LIM-type homeodomain protein needed for the differentiation of the touch cells.", "output": {"entities": {"gene": [{"text": "unc-86", "start": 15, "end": 21}, {"text": "POU-type homeodomain protein", "start": 32, "end": 60}, {"text": "mec-3", "start": 113, "end": 118}, {"text": "LIM-type homeodomain protein", "start": 129, "end": 157}]}}, "schema": []}
{"input": "During the 2h resuscitation period, extracellular aspartate and glutamate concentrations in the cerebral striatum were higher during hypoxaemic resuscitation (p = 0. 044 and p = 0. 055, respectively) than during resuscitation with 21% O2 or 100% O2, suggesting an unfavourable accumulation of potent excitotoxins during hypoxaemic resuscitation.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, phosphatidylinositol (3, 4, 5) trisphosphate specifically stimulates the activity of ILK in vitro, and in addition, membrane targetted constitutively active Pi (3) K activates ILK in vivo.", "output": {"entities": {"gene": [{"text": "ILK", "start": 98, "end": 101}, {"text": "Pi (3) K", "start": 170, "end": 178}, {"text": "ILK", "start": 189, "end": 192}]}}, "schema": []}
{"input": "Transfection and in vitro binding studies identified within HEFT1 a promoter whose basal activity required a GC box activated by Sp1 or Sp3.", "output": {"entities": {"gene": [{"text": "HEFT1 a promoter", "start": 60, "end": 76}, {"text": "Sp1", "start": 129, "end": 132}, {"text": "Sp3", "start": 136, "end": 139}]}}, "schema": []}
{"input": "Plasma was tested before and after (14 +/-7. 5 [SD] days) surgery for IgG antibodies to the complex of heparin/platelet factor 4, using a standardized, validated enzyme-linked immunosorbent assay (ELISA).", "output": {"entities": {"gene": [{"text": "IgG antibodies", "start": 70, "end": 84}, {"text": "heparin/platelet factor 4", "start": 103, "end": 128}]}}, "schema": []}
{"input": "The FAS promoter was up-regulated by insulin through the proximal insulin response sequence containing an E-box motif at the-65-base pair position.", "output": {"entities": {"gene": [{"text": "FAS promoter", "start": 4, "end": 16}, {"text": "insulin", "start": 37, "end": 44}, {"text": "insulin response sequence", "start": 66, "end": 91}]}}, "schema": []}
{"input": "The effect of independent predictors on survival was examined in a Cox regression model with adjustment for existing illnesses.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of rhG-CSF on neutrophil functions and survival in sepsis induced diabetic rats.", "output": {"entities": {"gene": [{"text": "rhG-CSF", "start": 11, "end": 18}]}}, "schema": []}
{"input": "OBJECTIVE: The purpose of this article is to review balance instruments developed within the past 10 years that can be used in the clinic or home environment.", "output": {"entities": {}}, "schema": []}
{"input": "CASE REPORT: We observed a congenital skin defect located exclusively on the trunk.", "output": {"entities": {}}, "schema": []}
{"input": "Anastrozole is the first aromatase inhibitor to show a significant survival advantage over megestrol acetate in post-menopausal women with advanced breast cancer.", "output": {"entities": {"gene": [{"text": "aromatase", "start": 25, "end": 34}]}}, "schema": []}
{"input": "W.", "output": {"entities": {}}, "schema": []}
{"input": "Moritta) and contains Bis-GMA.", "output": {"entities": {}}, "schema": []}
{"input": "Mutation of either the AP-1 or the ets component of this site also prevented promoter activity in SMCs.", "output": {"entities": {"gene": [{"text": "AP-1", "start": 23, "end": 27}, {"text": "ets", "start": 35, "end": 38}]}}, "schema": []}
{"input": "ANIMALS: Fifty dogs with naturally developing DM.", "output": {"entities": {}}, "schema": []}
{"input": "Surprisingly, double mutants of the shy2-1D mutant with the phytochrome-deficient mutants hy2, hy3 (phyB-1) and fre1-1 (phyA-201) showed reduced photomorphogenic response in darkness with a longer hypocotyl, a longer inflorescence stem, and a lower level expression of the CAB gene than the shy2-1D single mutant.", "output": {"entities": {"gene": [{"text": "shy2-1D mutant", "start": 36, "end": 50}, {"text": "phytochrome", "start": 60, "end": 71}, {"text": "hy2", "start": 90, "end": 93}, {"text": "hy3", "start": 95, "end": 98}, {"text": "phyB-1", "start": 100, "end": 106}, {"text": "fre1-1", "start": 112, "end": 118}, {"text": "phyA-201", "start": 120, "end": 128}, {"text": "CAB gene", "start": 273, "end": 281}, {"text": "shy2-1D single mutant", "start": 291, "end": 312}]}}, "schema": []}
{"input": "Laser ablation has been employed as a therapeutic measure for chronic pulmonary emphysema.", "output": {"entities": {}}, "schema": []}
{"input": "The SH2-containing adapter protein GRB10 interacts with BCR-ABL.", "output": {"entities": {"gene": [{"text": "GRB10", "start": 35, "end": 40}, {"text": "BCR", "start": 56, "end": 59}, {"text": "ABL", "start": 60, "end": 63}]}}, "schema": []}
{"input": "Saccharomyces cerevisiae contains four known acyl-CoA synthetases (fatty acid activation proteins, Faaps).", "output": {"entities": {"gene": [{"text": "acyl-CoA synthetases", "start": 45, "end": 65}, {"text": "fatty acid activation proteins", "start": 67, "end": 97}, {"text": "Faaps", "start": 99, "end": 104}]}}, "schema": []}
{"input": "We recently reported a placenta-specific enhancer in the human leukemia inhibitory factor receptor (LIFR) gene and now show detailed characterization of the 226-base pair enhancer (-4625/-4400 nucleotides).", "output": {"entities": {"gene": [{"text": "human leukemia inhibitory factor receptor", "start": 57, "end": 98}, {"text": "LIFR", "start": 100, "end": 104}]}}, "schema": []}
{"input": "Copyright 1998 Elsevier Science B. V.", "output": {"entities": {}}, "schema": []}
{"input": "It may be time to reevaluate the dichotomy between AD and VaD.", "output": {"entities": {}}, "schema": []}
{"input": "Clone 39 was a homolog of CONSTANS, which is a gene involved in controlling the flowering time in Arabidopsis.", "output": {"entities": {"gene": [{"text": "CONSTANS", "start": 26, "end": 34}]}}, "schema": []}
{"input": "The effects of high intensity light emissions, produced by a novel pulsed power energization technique (PPET), on the survival of bacterial populations of verocytotoxigenic Escherichia coli (serotype 0157: H7) and Listeria monocytogenes (serotype 4b) were investigated.", "output": {"entities": {}}, "schema": []}
{"input": "Multiple chemical sensitivity (MCS) is a syndrome in which multiple symptoms reportedly occur with low-level chemical exposure.", "output": {"entities": {}}, "schema": []}
{"input": "POU-domain proteins, such as the pituitary-specific factor Pit-1, are members of the homeodomain family of proteins which are important in development and homeostasis, acting constitutively or in response to signal-transduction pathways to either repress or activate the expression of specific genes.", "output": {"entities": {"gene": [{"text": "POU-domain proteins", "start": 0, "end": 19}, {"text": "pituitary-specific factor Pit-1", "start": 33, "end": 64}, {"text": "homeodomain family", "start": 85, "end": 103}]}}, "schema": []}
{"input": "Wild-type and mutant MyoD were introduced into cells using an E1, E3-deleted adenoviral vector.", "output": {"entities": {"gene": [{"text": "MyoD", "start": 21, "end": 25}, {"text": "E1", "start": 62, "end": 64}, {"text": "E3", "start": 66, "end": 68}]}}, "schema": []}
{"input": "These results suggest that Thr115 may play an important role in the regulation of MyoD function under conditions of high mitogenesis.", "output": {"entities": {"gene": [{"text": "MyoD", "start": 82, "end": 86}]}}, "schema": []}
{"input": "This and previous results suggest that the CRE and Sp1 site may synergistically activate TH transcription in a promoter context-dependent manner.", "output": {"entities": {"gene": [{"text": "Sp1 site", "start": 51, "end": 59}, {"text": "TH", "start": 89, "end": 91}]}}, "schema": []}
{"input": "Endoscopic examinations, peripheral white blood cell (WBC) counts, and assays of myeloperoxidase activity (MPO) in homogenates of colon mucosa were performed after one week (4% DSS model) and eight weeks (1% DSS model).", "output": {"entities": {"gene": [{"text": "myeloperoxidase", "start": 81, "end": 96}, {"text": "MPO", "start": 107, "end": 110}]}}, "schema": []}
{"input": "T7 transcription could be manipulated to achieve different levels of constitutive expression, through the use of promoter mutations.", "output": {"entities": {}}, "schema": []}
{"input": "The primers were degenerate sets of oligonucleotides derived from known amino acid sequences of the PBAN precursor.", "output": {"entities": {"gene": [{"text": "PBAN precursor", "start": 100, "end": 114}]}}, "schema": []}
{"input": "Plants transformed with the 35S-1-sst construct accumulated the oligofructans 1-kestose (GF2), 1, 1-nystose (GF3) and 1, 1, 1-fructosylnystose (GF4).", "output": {"entities": {"gene": [{"text": "35S", "start": 28, "end": 31}, {"text": "1-sst", "start": 32, "end": 37}]}}, "schema": []}
{"input": "Based on the comparison of the predicted amino acid sequences of 1-sst and 1-fft with those of other plant fructosyl transferase genes, we postulate that both plant fructan genes have evolved from plant invertase genes.", "output": {"entities": {"gene": [{"text": "1-sst", "start": 65, "end": 70}, {"text": "1-fft", "start": 75, "end": 80}, {"text": "fructosyl transferase genes", "start": 107, "end": 134}, {"text": "fructan genes", "start": 165, "end": 178}, {"text": "invertase", "start": 203, "end": 212}]}}, "schema": []}
{"input": "However, ICK1 was induced by ABA, and along with ICK1 induction there was a decrease in Cdc2-like histone H1 kinase activity.", "output": {"entities": {"gene": [{"text": "ICK1", "start": 9, "end": 13}, {"text": "ICK1", "start": 49, "end": 53}, {"text": "Cdc2-like histone H1 kinase", "start": 88, "end": 115}]}}, "schema": []}
{"input": "Here, we report that swa5-1 is a new temperature-sensitive allele of the clathrin heavy chain gene (chc1-5), which carries a frameshift mutation near the 3' end of the CHC1 open reading frame.", "output": {"entities": {"gene": [{"text": "swa5-1", "start": 21, "end": 27}, {"text": "clathrin heavy chain gene", "start": 73, "end": 98}, {"text": "chc1-5", "start": 100, "end": 106}, {"text": "CHC1", "start": 168, "end": 172}]}}, "schema": []}
{"input": "We have determined the molecular lesions of nine Scm mutant alleles, which identify functional requirements for specific domains.", "output": {"entities": {"gene": [{"text": "Scm mutant alleles", "start": 49, "end": 67}]}}, "schema": []}
{"input": "Intriguingly, three hypomorphic Scm mutations, which map within an mbt repeat, interact with PcG mutations more strongly than do Scm null alleles.", "output": {"entities": {"gene": [{"text": "Scm", "start": 32, "end": 35}, {"text": "mbt repeat", "start": 67, "end": 77}, {"text": "PcG mutations", "start": 93, "end": 106}, {"text": "Scm", "start": 129, "end": 132}]}}, "schema": []}
{"input": "Northern analysis revealed no detectable expression of the transcript in diapause-or nondiapause-programmed wandering larvae, and only trace expression in nondiapausing pupae.", "output": {"entities": {}}, "schema": []}
{"input": "Besides the characterization and discussion of the experimental setup used, the rate constants obtained are discussed and compared with estimated values.", "output": {"entities": {}}, "schema": []}
{"input": "The presence of PDZ and SAM domains in the KS5 protein suggests that it may act as a molecular adaptor, promoting and relaying information in a signal transduction pathway.", "output": {"entities": {"gene": [{"text": "PDZ", "start": 16, "end": 19}, {"text": "KS5 protein", "start": 43, "end": 54}]}}, "schema": []}
{"input": "BACKGROUND: Fluoroquinolones (FQ) are contraindicated in children because of the risk of cartilage damage.", "output": {"entities": {}}, "schema": []}
{"input": "In analyses with control for multiple variables, relative risk for microalbuminuria (urinary albumin excretion, 20-199 microg/min) in men and women was 2. 51 and 1. 62, respectively, with 18 mm Hg higher (1 SD) systolic blood pressure; 2. 25 and 2. 10, respectively, with 1. 0-mmol/L (40 mg/dL) higher plasma cholesterol level; 1. 99 and 1. 91, respectively, for smokers vs nonsmokers; and 1. 83 and 1. 33, respectively, with 4 kg/m2 higher body mass index.", "output": {"entities": {}}, "schema": []}
{"input": "However, while IL-1beta and TNF-alpha both induced nuclear binding of the Rel proteins p50 and p65 to an NF-kappaB consensus oligonucleotide in gel shift assays and caused transient degradation of inhibitor of NF-kappaB-alpha (IkappaB-alpha) in the cytoplasm of myofibroblasts, only IL-1beta upregulated PDGF-Ralpha.", "output": {"entities": {"gene": [{"text": "IL-1beta", "start": 15, "end": 23}, {"text": "TNF-alpha", "start": 28, "end": 37}, {"text": "Rel proteins p50", "start": 74, "end": 90}, {"text": "p65", "start": 95, "end": 98}, {"text": "NF-kappaB consensus oligonucleotide", "start": 105, "end": 140}, {"text": "inhibitor of NF-kappaB-alpha", "start": 197, "end": 225}, {"text": "IkappaB-alpha", "start": 227, "end": 240}, {"text": "IL-1beta", "start": 283, "end": 291}, {"text": "PDGF-Ralpha", "start": 304, "end": 315}]}}, "schema": []}
{"input": "Cotransfections with ATF-2 and HNF-4 expression plasmids resulted in additive transactivation of the apoCIII promoter.", "output": {"entities": {"gene": [{"text": "ATF-2", "start": 21, "end": 26}, {"text": "HNF-4", "start": 31, "end": 36}, {"text": "apoCIII promoter", "start": 101, "end": 117}]}}, "schema": []}
{"input": "Phosphocreatine hydrolysis during submaximal exercise: the effect of FIO2.", "output": {"entities": {}}, "schema": []}
{"input": "Pseudocontact shifts arise from the isotropic reorientational average of the dipolar coupling between unpaired electron and nuclei, in the presence of magnetic susceptibility anisotropy.", "output": {"entities": {}}, "schema": []}
{"input": "GETS-1 is expressed in many tissues, but is enriched in retina and brain.", "output": {"entities": {"gene": [{"text": "GETS-1", "start": 0, "end": 6}]}}, "schema": []}
{"input": "The interaction of U1-70K with the SRZ proteins is confirmed further in vitro using a blot overlay assay.", "output": {"entities": {"gene": [{"text": "U1-70K", "start": 19, "end": 25}, {"text": "SRZ proteins", "start": 35, "end": 47}]}}, "schema": []}
{"input": "The major phenotypes resulting from Fab1p kinase inactivation include temperature-sensitive growth, vacuolar acidification defects, and dramatic increases in vacuolar size.", "output": {"entities": {"gene": [{"text": "Fab1p kinase", "start": 36, "end": 48}]}}, "schema": []}
{"input": "Interestingly, an antibody against N-SMase can abrogate Ox-LDL-and TNF-alpha-induced apoptosis and therefore may be useful for in vivo studies of apoptosis in experimental animals.", "output": {"entities": {"gene": [{"text": "N-SMase", "start": 35, "end": 42}, {"text": "Ox-LDL", "start": 56, "end": 62}, {"text": "TNF-alpha", "start": 67, "end": 76}]}}, "schema": []}
{"input": "We found that virulent Ngo strains induce phosphorylation and activation of JNK but not of p38 kinase.", "output": {"entities": {"gene": [{"text": "JNK", "start": 76, "end": 79}, {"text": "p38", "start": 91, "end": 94}]}}, "schema": []}
{"input": "Focused beams of classical light ablate elements of the cell division machinery and switch the beating of hearts on a cellular basis.", "output": {"entities": {}}, "schema": []}
{"input": "The human T cell lymphotropic retrovirus type I (HTLV-I) trans-activator, Tax, interacts specifically with the basic-domain/leucine-zipper (bZip) protein, cAMP response element binding protein (CREB), bound to the viral Tax-responsive element consisting of three imperfect 21-base pair repeats, each with a cAMP response element core flanked by G/C-rich sequences.", "output": {"entities": {"gene": [{"text": "Tax", "start": 74, "end": 77}, {"text": "basic-domain/leucine-zipper (bZip) protein", "start": 111, "end": 153}, {"text": "cAMP response element binding protein", "start": 155, "end": 192}, {"text": "CREB", "start": 194, "end": 198}, {"text": "viral Tax-responsive element", "start": 214, "end": 242}]}}, "schema": []}
{"input": "This sequence is very similar to the insulin response sequence found in the regulatory region of other genes negatively regulated by insulin such as those encoding phosphoenolpyruvate carboxykinase, tyrosine aminotransferase, and insulin-like growth factor-binding protein 1.", "output": {"entities": {"gene": [{"text": "insulin response sequence", "start": 37, "end": 62}, {"text": "insulin", "start": 133, "end": 140}, {"text": "phosphoenolpyruvate carboxykinase", "start": 164, "end": 197}, {"text": "tyrosine aminotransferase", "start": 199, "end": 224}, {"text": "insulin-like growth factor-binding protein 1", "start": 230, "end": 274}]}}, "schema": []}
{"input": "The murine facilitative glucose transporter isoform 3 (Glut 3) is developmentally regulated and is predominantly expressed in neurons and trophoblasts.", "output": {"entities": {"gene": [{"text": "murine facilitative glucose transporter isoform 3", "start": 4, "end": 53}, {"text": "Glut 3", "start": 55, "end": 61}]}}, "schema": []}
{"input": "However, changing the half-site to the consensus sequence AGGTCA (IRper-1) increased binding of AaEcR. AaUSP 10-fold over IRhsp-1 and, at the same time, reduced the stringency of the spacer length requirement, with IRper-0 to IRper-5 showing detectable binding.", "output": {"entities": {"gene": [{"text": "AaEcR. AaUSP", "start": 96, "end": 108}]}}, "schema": []}
{"input": "The levels of transactivation are correlated with the respective binding affinities of the response elements (IRper-1 > DR-4 > IRhsp-1).", "output": {"entities": {}}, "schema": []}
{"input": "The high density of tegumental spines on posterior half of the body and the distribution of type II papillae on dorsal surface are considered to be characteristic of C. armatus.", "output": {"entities": {}}, "schema": []}
{"input": "Inactivation of p53 but not p73 by adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins.", "output": {"entities": {"gene": [{"text": "p53", "start": 16, "end": 19}, {"text": "p73", "start": 28, "end": 31}, {"text": "adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins", "start": 35, "end": 104}]}}, "schema": []}
{"input": "The Epstein-Barr virus transactivator Zta triggers lytic gene expression and is essential for replication of the lytic origin, oriLyt.", "output": {"entities": {"gene": [{"text": "Epstein-Barr virus transactivator Zta", "start": 4, "end": 41}]}}, "schema": []}
{"input": "Cotransfection of the helicase-primase proteins, one of which was fused to a heterologous activation domain, led to Zta-dependent superactivation of CAT expression.", "output": {"entities": {"gene": [{"text": "helicase", "start": 22, "end": 30}, {"text": "primase", "start": 31, "end": 38}, {"text": "Zta", "start": 116, "end": 119}, {"text": "CAT", "start": 149, "end": 152}]}}, "schema": []}
{"input": "A single rectal dose of 25 mg/kg will obtain this lower concentration within 1 h of administration and maintain it for up to 6 h.", "output": {"entities": {}}, "schema": []}
{"input": "Although YopH is a highly active PTP, it preferentially targets a subset of tyrosine-phosphorylated proteins in host cells, including p130Cas.", "output": {"entities": {"gene": [{"text": "YopH", "start": 9, "end": 13}, {"text": "PTP", "start": 33, "end": 36}, {"text": "p130Cas", "start": 134, "end": 141}]}}, "schema": []}
{"input": "Phylogenetic position of the Phacotaceae within the Chlamydophyceaeas revealed by analysis of 18S rDNA and rbcL sequences.", "output": {"entities": {"gene": [{"text": "18S rDNA", "start": 94, "end": 102}, {"text": "rbcL sequences", "start": 107, "end": 121}]}}, "schema": []}
{"input": "The activation and injury of endothelial cells induced by TNF and other proinflammatory cytokines may underlie the local effects of these mediators in vivo.", "output": {"entities": {"gene": [{"text": "TNF", "start": 58, "end": 61}]}}, "schema": []}
{"input": "A technique for thermal imaging of the animal and human brain cortex using an infrared optical system is described.", "output": {"entities": {}}, "schema": []}
{"input": "Here we demonstrate that THOV NP contains a motif (KRxxxxxxxxxKTKK) at amino acid positions 179-193 that represents a classical bipartite nuclear localization signal (NLS).", "output": {"entities": {"gene": [{"text": "THOV NP", "start": 25, "end": 32}]}}, "schema": []}
{"input": "As PP2A exerts a range of cellular functions including cell cycle regulation and cell fate determination, we were surprised to find that these embryos develop normally until postimplantation, around embryonic day 5. 5/6. 0.", "output": {"entities": {"gene": [{"text": "PP2A", "start": 3, "end": 7}]}}, "schema": []}
{"input": "The most frequent risk factor for ischaemic was hypertension.", "output": {"entities": {}}, "schema": []}
{"input": "The results indicate that anthraquinone sennoside B and rhein are weakly genotoxic.", "output": {"entities": {}}, "schema": []}
{"input": "16 subjects were repatch tested to ethylmercury chloride (EtHgCl) and to solutions containing EtHgCl mixed with L-cysteine and glutathione, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "The carboxyl-terminal portion of UKLF contains three zinc fingers of the Cys2-His2 type and binds in vitro to the CACCC motif of the beta-globin promoter and to the Sp1 recognition sequence.", "output": {"entities": {"gene": [{"text": "UKLF", "start": 33, "end": 37}, {"text": "beta-globin promoter", "start": 133, "end": 153}, {"text": "Sp1 recognition sequence", "start": 165, "end": 189}]}}, "schema": []}
{"input": "We have recently identified a mouse enzyme termed gamma-glutamyl leukotrienase (GGL) that converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4).", "output": {"entities": {"gene": [{"text": "gamma-glutamyl leukotrienase", "start": 50, "end": 78}, {"text": "GGL", "start": 80, "end": 83}]}}, "schema": []}
{"input": "UGA codon position affects the efficiency of selenocysteine incorporation into glutathione peroxidase-1.", "output": {"entities": {"gene": [{"text": "glutathione peroxidase-1", "start": 79, "end": 103}]}}, "schema": []}
{"input": "Forskolin significantly enhanced heregulin-stimulated expression of cyclin D and phosphorylation of the retinoblastoma gene product.", "output": {"entities": {"gene": [{"text": "heregulin", "start": 33, "end": 42}, {"text": "cyclin D", "start": 68, "end": 76}, {"text": "retinoblastoma gene product", "start": 104, "end": 131}]}}, "schema": []}
{"input": "The ARF promoter was also found to be highly responsive to E2F1 expression, in keeping with previous results at the RNA level.", "output": {"entities": {"gene": [{"text": "ARF promoter", "start": 4, "end": 16}, {"text": "E2F1", "start": 59, "end": 63}]}}, "schema": []}
{"input": "Observers with brain injury and control participants performed a vigilance task during which they received periodic whiffs of unscented air or air scented with peppermint.", "output": {"entities": {}}, "schema": []}
{"input": "A simple analytical method for l-menthol by high-performance liquid chromatography with a polarized photometric detector was established.", "output": {"entities": {}}, "schema": []}
{"input": "After measuring baseline Vmca at a partial pressure of carbon dioxide in arterial blood (PaCO2) of 37. 7 +/-4. 5 mmHg (mean +/-SD), measurements were repeated at a PaCO of 44. 2 +/-3. 8 mmHg, and the carbon dioxide reactivity (absolute value: cm x s (-1) x mmHg (-1); relative value: percentage of baseline Vmca/mmHg) was calculated.", "output": {"entities": {}}, "schema": []}
{"input": "Multivariate Cox survival analysis identified baseline EF < or = 30%, presence of significant mitral regurgitation (> 2 +) before ablation, and failure to exhibit improved cardiac performance by 1 month after ablation as the only independent predictors of death.", "output": {"entities": {}}, "schema": []}
{"input": "We have developed a new method for estimation of regional CBF (rCBF) and cerebrovascular reserve capacity on a pixel-by-pixel basis by means of dynamic magnetic resonance imaging (MRI).", "output": {"entities": {}}, "schema": []}
{"input": "Cost-effectiveness analysis provides a rational means of allocating limited health care resources by allowing the comparison of the costs of lipid-lowering therapy, in particular, therapy with beta-hydroxy-beta-methylglutaryl-CoA (coenzyme A) reductase inhibitors (statins), with the costs of atherosclerosis that could be prevented by lowering cholesterol.", "output": {"entities": {"gene": [{"text": "beta-hydroxy-beta-methylglutaryl-CoA (coenzyme A) reductase", "start": 193, "end": 252}]}}, "schema": []}
{"input": "Although E2FBP1 lacks the transactivation domain, it stimulates E2F site-dependent transcription in cooperation with E2F-1.", "output": {"entities": {"gene": [{"text": "E2FBP1", "start": 9, "end": 15}, {"text": "E2F", "start": 64, "end": 67}, {"text": "E2F-1", "start": 117, "end": 122}]}}, "schema": []}
{"input": "Analysis of Msy2 mRNA expression in prepubertal and adult mouse testes, and in isolated populations of germ cells, reveals maximal expression in postmeiotic round spermatids, a cell type with abundant amounts of stored messenger ribonucleoproteins.", "output": {"entities": {"gene": [{"text": "Msy2 mRNA", "start": 12, "end": 21}]}}, "schema": []}
{"input": "1 in Ho Chi Minh City was studied by culture and latex agglutination of blood, cerebrospinal fluid, urine and pleural fluid.", "output": {"entities": {}}, "schema": []}
{"input": "Glycogen synthesis and catabolism, gluconeogenesis, glycolysis, motility, cell surface properties and adherence are modulated by csrA in Escherichia coli, while the production of several secreted virulence factors, the plant hypersensitive response elicitor HrpN (Ecc) and, potentially, other secondary metabolites are regulated by rsmA in Erwinia carotovora.", "output": {"entities": {"gene": [{"text": "csrA in Escherichia coli", "start": 129, "end": 153}, {"text": "HrpN", "start": 258, "end": 262}, {"text": "Ecc", "start": 264, "end": 267}, {"text": "rsmA in Erwinia carotovora", "start": 332, "end": 358}]}}, "schema": []}
{"input": "Deletion analysis revealed that the essential domain of this promoter, termed the ORF5/deltaX transcript promoter, mapped to nucleotides 1525-1625.", "output": {"entities": {"gene": [{"text": "ORF5/deltaX transcript promoter", "start": 82, "end": 113}]}}, "schema": []}
{"input": "Some of the peptide: MBP fusions were also analyzed using surface plasmon resonance.", "output": {"entities": {"gene": [{"text": "peptide: MBP fusions", "start": 12, "end": 32}]}}, "schema": []}
{"input": "Cardiac myosin-binding protein C (MyBP-C): identification of protein kinase A and protein kinase C phosphorylation sites.", "output": {"entities": {"gene": [{"text": "Cardiac myosin-binding protein C", "start": 0, "end": 32}, {"text": "MyBP-C", "start": 34, "end": 40}, {"text": "protein kinase A", "start": 61, "end": 77}, {"text": "protein kinase C", "start": 82, "end": 98}]}}, "schema": []}
{"input": "Analysis of chromosomal DNA sequence immediately downstream of the transposon insertion identified two open reading frames, designated csrR and csrS, which exhibited sequence similarity to bacterial two-component regulatory systems.", "output": {"entities": {"gene": [{"text": "csrR", "start": 135, "end": 139}, {"text": "csrS", "start": 144, "end": 148}]}}, "schema": []}
{"input": "We previously delineated a region in the fatty-acid synthase promoter, which was responsible for obesity-related overexpression of the fatty-acid synthase (FAS) gene, by negatively regulating the activity of the downstream promoter in lean but not obese rat fat cells.", "output": {"entities": {"gene": [{"text": "fatty-acid synthase promoter", "start": 41, "end": 69}, {"text": "fatty-acid synthase", "start": 135, "end": 154}, {"text": "FAS", "start": 156, "end": 159}]}}, "schema": []}
{"input": "Finally, using in vitro binding studies, we showed that SREBP2 was able to displace ADD1/SREBP1 binding from the sterol regulatory element (SRE) site.", "output": {"entities": {"gene": [{"text": "SREBP2", "start": 56, "end": 62}, {"text": "ADD1", "start": 84, "end": 88}, {"text": "SREBP1", "start": 89, "end": 95}]}}, "schema": []}
{"input": "Thus, IRF-7 exhibits functional similarity to IRF-3; however, the preferential expression of IRF-7 in lymphoid cells (the cell type that expresses IFNA) suggests that IRF-7 may play a critical role in regulating the IFNA gene expression.", "output": {"entities": {"gene": [{"text": "IRF-7", "start": 6, "end": 11}, {"text": "IRF-3", "start": 46, "end": 51}, {"text": "IRF-7", "start": 93, "end": 98}, {"text": "IFNA", "start": 147, "end": 151}, {"text": "IRF-7", "start": 167, "end": 172}, {"text": "IFNA gene", "start": 216, "end": 225}]}}, "schema": []}
{"input": "J.", "output": {"entities": {}}, "schema": []}
{"input": "PURPOSE: The role interleukin-6 (IL-6) in the treatment of congenital thrombocytopenias is unknown.", "output": {"entities": {"gene": [{"text": "interleukin-6", "start": 18, "end": 31}, {"text": "IL-6", "start": 33, "end": 37}]}}, "schema": []}
{"input": "CKII as a CD44-associated serine kinase therefore may serve as an important molecule in a signaling cascade that produces a variety of cellular responses in MDA231 breast cancer cells.", "output": {"entities": {"gene": [{"text": "CKII", "start": 0, "end": 4}, {"text": "CD44-associated serine kinase", "start": 10, "end": 39}]}}, "schema": []}
{"input": "Galphaq, Galpha12, and Galpha13, but not Galphai, activate SRF through RhoA.", "output": {"entities": {"gene": [{"text": "Galphaq", "start": 0, "end": 7}, {"text": "Galpha12", "start": 9, "end": 17}, {"text": "Galpha13", "start": 23, "end": 31}, {"text": "Galphai", "start": 41, "end": 48}, {"text": "SRF", "start": 59, "end": 62}, {"text": "RhoA", "start": 71, "end": 75}]}}, "schema": []}
{"input": "Additionally in seven subjects adrenaline (A) and noradrenaline (NA) concentrations were determined.", "output": {"entities": {}}, "schema": []}
{"input": "Northern blot analyses show that the hBub1 mRNA level is abundantly expressed in tissues or cells with a high mitotic index.", "output": {"entities": {"gene": [{"text": "hBub1 mRNA", "start": 37, "end": 47}]}}, "schema": []}
{"input": "We mapped two overlapping expressed sequence tag clones within a genomic contig on human chromosome 5, band q31.", "output": {"entities": {}}, "schema": []}
{"input": "Htra2-beta3 is developmentally regulated and expressed predominantly in brain, liver testis, and weakly in kidney.", "output": {"entities": {"gene": [{"text": "Htra2-beta3", "start": 0, "end": 11}]}}, "schema": []}
{"input": "Gng3lg transcripts are expressed in a variety of tissues including both brain and testes.", "output": {"entities": {"gene": [{"text": "Gng3lg transcripts", "start": 0, "end": 18}]}}, "schema": []}
{"input": "Using an interspecific backcross panel, we localized both Gng3 and Gng3lg to the same locus on chromosome 19.", "output": {"entities": {"gene": [{"text": "Gng3", "start": 58, "end": 62}, {"text": "Gng3lg", "start": 67, "end": 73}]}}, "schema": []}
{"input": "We also raised a polyclonal antibody against the glutathione S-transferase fusion protein containing the NH2-terminal 86 amino acids of human NRAMP2.", "output": {"entities": {"gene": [{"text": "glutathione S-transferase fusion protein", "start": 49, "end": 89}, {"text": "human NRAMP2", "start": 136, "end": 148}]}}, "schema": []}
{"input": "Inhibition of the apolipoprotein B mRNA editing enzyme-complex by hnRNP C1 protein and 40S hnRNP complexes.", "output": {"entities": {"gene": [{"text": "apolipoprotein B mRNA", "start": 18, "end": 39}, {"text": "hnRNP C1 protein", "start": 66, "end": 82}, {"text": "40S hnRNP complexes", "start": 87, "end": 106}]}}, "schema": []}
{"input": "SRC-1 can relieve the NF-kappaB-mediated repression of GR activity.", "output": {"entities": {"gene": [{"text": "SRC-1", "start": 0, "end": 5}, {"text": "NF-kappaB", "start": 22, "end": 31}, {"text": "GR", "start": 55, "end": 57}]}}, "schema": []}
{"input": "However the sequence surrounding the transcription start site CTCA (+ 1) TTCC was similar to the consensus CTCA (+ 1) NTCT (N is any nucleoside) for an initiator element found in terminal deoxynucleotidyltransferase and a number of other highly regulated genes.", "output": {"entities": {"gene": [{"text": "terminal deoxynucleotidyltransferase", "start": 179, "end": 215}]}}, "schema": []}
{"input": "Expression of a dominant-negative mutant of JNK1 also suppressed glucose deprivation-induced JNK1 activation as well as HSP70 gene expression.", "output": {"entities": {"gene": [{"text": "JNK1", "start": 44, "end": 48}, {"text": "JNK1", "start": 93, "end": 97}, {"text": "HSP70 gene", "start": 120, "end": 130}]}}, "schema": []}
{"input": "The interaction of AF-1 with proteins that regulate distinct steps of transcription may provide a mechanism for synergistic activation of gene expression by AF-1.", "output": {"entities": {}}, "schema": []}
{"input": "The role of protein kinase C signaling in activated DRA transcription.", "output": {"entities": {"gene": [{"text": "protein kinase C", "start": 12, "end": 28}, {"text": "DRA", "start": 52, "end": 55}]}}, "schema": []}
{"input": "Ligand binding to the receptor complex leads to tyrosine phosphorylation and activation of Janus kinases (Jak), phosphorylation of the signal transducing subunit gp130, followed by recruitment and phosphorylation of the signal transducer and activator of transcription factors STAT3 and STAT1 and the src homology domain (SH2)-containing protein tyrosine phosphatase (SHP2).", "output": {"entities": {"gene": [{"text": "Janus kinases", "start": 91, "end": 104}, {"text": "Jak", "start": 106, "end": 109}, {"text": "signal transducing subunit gp130", "start": 135, "end": 167}, {"text": "signal transducer and activator of transcription factors STAT3", "start": 220, "end": 282}, {"text": "STAT1", "start": 287, "end": 292}, {"text": "src homology domain", "start": 301, "end": 320}, {"text": "SH2", "start": 322, "end": 325}, {"text": "protein tyrosine phosphatase", "start": 338, "end": 366}, {"text": "SHP2", "start": 368, "end": 372}]}}, "schema": []}
{"input": "Interestingly, an increase of distance per se did not have a deleterious effect on translation efficiency.", "output": {"entities": {}}, "schema": []}
{"input": "We also mapped a 3'-polyadenylation site 504bp downstream of the TGA stop codon, consistent with the 2. 5kb transcript size.", "output": {"entities": {}}, "schema": []}
{"input": "RBP56 protein turned out to be hTAFII68 which was isolated as a TATA-binding protein associated factor (TAF) from a sub-population of TFIID complexes (Bertolotti A., Lutz, Y., Heard, D. J., Chambon, P., Tora, L., 1996. hTAFII68, a novel RNA/ssDNA-binding protein with homology to the proto-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II.", "output": {"entities": {"gene": [{"text": "RBP56 protein", "start": 0, "end": 13}, {"text": "hTAFII68", "start": 31, "end": 39}, {"text": "TATA-binding protein associated factor", "start": 64, "end": 102}, {"text": "TAF", "start": 104, "end": 107}, {"text": "TFIID complexes", "start": 134, "end": 149}, {"text": "hTAFII68", "start": 219, "end": 227}, {"text": "TLS", "start": 303, "end": 306}, {"text": "FUS", "start": 307, "end": 310}, {"text": "EWS", "start": 315, "end": 318}, {"text": "TFIID", "start": 343, "end": 348}, {"text": "RNA polymerase II", "start": 353, "end": 370}]}}, "schema": []}
{"input": "An electrophoretic mobility shift assay was performed to characterize the binding property of TR2 and its truncated isoform.", "output": {"entities": {"gene": [{"text": "TR2", "start": 94, "end": 97}]}}, "schema": []}
{"input": "Gel-mobility shift analysis was also performed for the CCAAT motif at-67.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: We identified a full-length cDNA with an open reading frame of 2883 bp corresponding to a predicted protein of 961 amino acids that shares greater than 95% homology with the rat gamma-aminobutyric acid B (GABAB) receptor.", "output": {"entities": {"gene": [{"text": "rat gamma-aminobutyric acid B (GABAB) receptor", "start": 183, "end": 229}]}}, "schema": []}
{"input": "On Day 8, the CIDR-B was removed and 500 micrograms cloprostenol injected, IM.", "output": {"entities": {}}, "schema": []}
{"input": "Another tentative hotspot mutation in the third patient, a frame shift caused by a G nucleotide insertion in a monotonous repeat of six Gs in HPRT exon 3, has been reported previously in three other LN patients.", "output": {"entities": {"gene": [{"text": "HPRT exon 3", "start": 142, "end": 153}]}}, "schema": []}
{"input": "SRF-deficient embryos (Srf-/-) have a severe gastrulation defect and do not develop to term.", "output": {"entities": {"gene": [{"text": "SRF", "start": 0, "end": 3}, {"text": "Srf", "start": 23, "end": 26}]}}, "schema": []}
{"input": "These characteristic structural features were used to create the abbreviation AZF1 (Asparagine-rich Zinc Finger protein).", "output": {"entities": {"gene": [{"text": "AZF1", "start": 78, "end": 82}, {"text": "Asparagine-rich Zinc Finger protein", "start": 84, "end": 119}]}}, "schema": []}
{"input": "Over-expression of Azf1p in the yeast cell does not influence the expression level of the mitochondrial transcription factor Mtf1p, indicating that the influence of Azf1p on the suppression of the special mitochondrial RNA polymerase mutant is an indirect one.", "output": {"entities": {"gene": [{"text": "Azf1p", "start": 19, "end": 24}, {"text": "mitochondrial transcription factor Mtf1p", "start": 90, "end": 130}, {"text": "Azf1p", "start": 165, "end": 170}, {"text": "mitochondrial RNA polymerase mutant", "start": 205, "end": 240}]}}, "schema": []}
{"input": "We have generated a computer model of the C-terminal domain of the 434 repressor based on the crystal structure of the homologous UmuD' protein.", "output": {"entities": {"gene": [{"text": "homologous UmuD' protein", "start": 119, "end": 143}]}}, "schema": []}
{"input": "Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.", "output": {"entities": {"gene": [{"text": "EPO", "start": 114, "end": 117}, {"text": "CUTL1 loci", "start": 122, "end": 132}]}}, "schema": []}
{"input": "Because Trp53 (the mouse homolog of human TP53) is located with Tk1 on chromosome 11 and is critical in regulating cellular responses following exposure to DNA damaging agents, we wanted to determine if these mouse lymphoma cells harbor mutations in Trp53.", "output": {"entities": {"gene": [{"text": "Trp53", "start": 8, "end": 13}, {"text": "mouse homolog of human TP53", "start": 19, "end": 46}, {"text": "Tk1", "start": 64, "end": 67}, {"text": "Trp53", "start": 250, "end": 255}]}}, "schema": []}
{"input": "One of these fragments shows the highest amino acid sequence homology to the insect ecdysone inducible gene E75.", "output": {"entities": {"gene": [{"text": "gene E75", "start": 103, "end": 111}]}}, "schema": []}
{"input": "The full-length N gene, encoded by open reading frame 7, was cloned from the Canadian PRRS virus, PA-8.", "output": {"entities": {"gene": [{"text": "N gene", "start": 16, "end": 22}]}}, "schema": []}
{"input": "Based on sequence homology, the genes were identified as TEF, encoding translation elongation factor-1 alpha and RPS7, encoding ribosomal protein S7.", "output": {"entities": {"gene": [{"text": "TEF", "start": 57, "end": 60}, {"text": "translation elongation factor-1 alpha", "start": 71, "end": 108}, {"text": "RPS7", "start": 113, "end": 117}, {"text": "S7", "start": 146, "end": 148}]}}, "schema": []}
{"input": "We have previously shown that ARNO localizes to the plasma membrane in vivo and efficiently catalyzes ARF6 nucleotide exchange in vitro.", "output": {"entities": {"gene": [{"text": "ARNO", "start": 30, "end": 34}, {"text": "ARF6", "start": 102, "end": 106}]}}, "schema": []}
{"input": "Renal pathology and long-term outcome in childhood SLE.", "output": {"entities": {}}, "schema": []}
{"input": "Transcription factors of the Stat family are controlled by protein kinases.", "output": {"entities": {"gene": [{"text": "Stat family", "start": 29, "end": 40}]}}, "schema": []}
{"input": "We propose that two pathways regulate Stat5 serine phosphorylation, one that is prolactin-activated and PD98059-resistant and one that is constitutively active and PD98059-sensitive and preferentially targets Stat5a.", "output": {"entities": {"gene": [{"text": "Stat5", "start": 38, "end": 43}, {"text": "prolactin", "start": 80, "end": 89}, {"text": "Stat5a", "start": 209, "end": 215}]}}, "schema": []}
{"input": "An approximately 37-kDa cytoplasmic protein is rapidly tyrosine-phosphorylated in the response of mouse BAC1. 2F5 macrophages to colony stimulating factor-1 (CSF-1). pp37 was purified from the cytosolic fraction by anti-Tyr (P) affinity chromatography, size exclusion chromatography, and C4 reverse phase high pressure liquid chromatography.", "output": {"entities": {"gene": [{"text": "colony stimulating factor-1", "start": 129, "end": 156}, {"text": "CSF-1", "start": 158, "end": 163}, {"text": "pp37", "start": 166, "end": 170}, {"text": "anti-Tyr (P)", "start": 215, "end": 227}]}}, "schema": []}
{"input": "Dose of 20 ig were administered within a scheme from 0. 1 to 6 months in order to study its immunogenicity, which was evaluated at 2, 7, and 12 months after the first dose.", "output": {"entities": {}}, "schema": []}
{"input": "This association was independently significant for patients treated primarily (not for recurrence).", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSION: Local control was highest with Preop in patients presenting primarily with gross disease, and with Postop in patients presenting primarily following gross total excision.", "output": {"entities": {}}, "schema": []}
{"input": "Its interaction with RFX5 and RFXAP is essential for binding of the RFX complex to MHC-II promoters.", "output": {"entities": {"gene": [{"text": "RFX5", "start": 21, "end": 25}, {"text": "RFXAP", "start": 30, "end": 35}, {"text": "RFX complex", "start": 68, "end": 79}, {"text": "MHC-II promoters", "start": 83, "end": 99}]}}, "schema": []}
{"input": "We have previously mapped the defect in RIIIS/J to distal mouse Chr 11, distinct from the Vwf locus on Chr 6.", "output": {"entities": {"gene": [{"text": "Vwf locus", "start": 90, "end": 99}]}}, "schema": []}
{"input": "These data may also aid in the localization of other disease loci mapped to this region, including the gene for tricho-dento-osseous syndrome and a murine locus for susceptibility to ozone-induced acute lung injury.", "output": {"entities": {}}, "schema": []}
{"input": "Copyright 1998 Academic Press.", "output": {"entities": {}}, "schema": []}
{"input": "An open reading frame encoding a protein which shows significant similarity to invertases and resolvases was located immediately upstream of the Pac25I R-M operon.", "output": {"entities": {"gene": [{"text": "invertases", "start": 79, "end": 89}, {"text": "resolvases", "start": 94, "end": 104}, {"text": "Pac25I R-M operon", "start": 145, "end": 162}]}}, "schema": []}
{"input": "Identification of a new gene in the streptococcal plasmid pLS1: the rnaI gene.", "output": {"entities": {"gene": [{"text": "rnaI gene", "start": 68, "end": 77}]}}, "schema": []}
{"input": "Rather, usp is required in late third instar larvae for appropriate developmental and transcriptional responses to the ecdysone pulse that triggers puparium formation.", "output": {"entities": {"gene": [{"text": "usp", "start": 8, "end": 11}]}}, "schema": []}
{"input": "An intact neurovascular supply is essential for the viability of a muscle flap.", "output": {"entities": {}}, "schema": []}
{"input": "BACKGROUND: Studies in lean men show poor regulation of energy (EB) and fat balance (FB) during manipulation of dietary ratios of fat to carbohydrate.", "output": {"entities": {}}, "schema": []}
{"input": "Fatal apneusis was observed under following conditions: (1) Persistent apnea was produced after a single KA microinjection in one side of the VRG-Apa (5 animals).", "output": {"entities": {}}, "schema": []}
{"input": "A comparative analysis of the reported MOCT-associated malignant melanomas emphasizes the singularity of our case in the amelanotic character of the melanoma, its lymphotropism and the coexistence of invasive squamous cell carcinoma.", "output": {"entities": {}}, "schema": []}
{"input": "These results indicate that HIV-1 Gag sequences can influence the viral PR-mediated processing of the MuLV TM Env protein p15 (E).", "output": {"entities": {"gene": [{"text": "Gag sequences", "start": 34, "end": 47}, {"text": "viral PR", "start": 66, "end": 74}, {"text": "TM Env protein p15 (E)", "start": 107, "end": 129}]}}, "schema": []}
{"input": "These results demonstrate a specific association of SIV and HIV-2 nef, but not HIV-1 nef, with TCRzeta.", "output": {"entities": {"gene": [{"text": "HIV-2 nef", "start": 60, "end": 69}, {"text": "HIV-1 nef", "start": 79, "end": 88}, {"text": "TCRzeta", "start": 95, "end": 102}]}}, "schema": []}
{"input": "Competition EMSA established that constitutively expressed nuclear proteins bound the KCS element selectively; KCS protein binding activity correlated with promoter activity in the transient transfection reporter assay.", "output": {"entities": {"gene": [{"text": "KCS element", "start": 86, "end": 97}, {"text": "KCS protein", "start": 111, "end": 122}]}}, "schema": []}
{"input": "Mechanism of interferon action: identification of essential positions within the novel 15-base-pair KCS element required for transcriptional activation of the RNA-dependent protein kinase pkr gene.", "output": {"entities": {"gene": [{"text": "interferon", "start": 13, "end": 23}, {"text": "15-base-pair KCS element", "start": 87, "end": 111}, {"text": "RNA-dependent protein kinase pkr gene", "start": 159, "end": 196}]}}, "schema": []}
{"input": "Expression of a novel murine phospholipase D homolog coincides with late neuronal development in the forebrain.", "output": {"entities": {"gene": [{"text": "murine phospholipase D homolog", "start": 22, "end": 52}]}}, "schema": []}
{"input": "We detected no effect of deleting YCL024W, either alone or in combination with deletion of GIN4.", "output": {"entities": {"gene": [{"text": "YCL024W", "start": 34, "end": 41}, {"text": "GIN4", "start": 91, "end": 95}]}}, "schema": []}
{"input": "Paralemmin is also phosphorylated, and its mRNA is differentially spliced in a tissue-specific and developmentally regulated manner.", "output": {"entities": {"gene": [{"text": "Paralemmin", "start": 0, "end": 10}]}}, "schema": []}
{"input": "The deduced amino acid sequence of CBP90 had no significant similarity to any other protein, but it had a proline-rich domain at the C-terminal region.", "output": {"entities": {"gene": [{"text": "CBP90", "start": 35, "end": 40}]}}, "schema": []}
{"input": "The effect of low-profile serine substitutions in the V3 loop of HIV-1 gp120 IIIB/LAI on the immunogenicity of the envelope protein.", "output": {"entities": {"gene": [{"text": "V3", "start": 54, "end": 56}, {"text": "gp120 IIIB", "start": 71, "end": 81}, {"text": "LAI", "start": 82, "end": 85}, {"text": "envelope", "start": 115, "end": 123}]}}, "schema": []}
{"input": "Transcription start site mapping identified the presence of an aphidicolin-sensitive late transcript arising from a TAAG motif located at-352 nucleotides and an aphidicolin-insensitive early transcript originating from a TTGT motif located 35 nucleotides downstream to a TATA box at-312 nucleotides, with respect to the + 1 ATG of lef2.", "output": {"entities": {"gene": [{"text": "lef2", "start": 331, "end": 335}]}}, "schema": []}
{"input": "The human 2', 5'-oligoadenylate (2-5A) synthetases are members of a family interferon (IFN)-inducible anti-viral proteins.", "output": {"entities": {"gene": [{"text": "human 2', 5'-oligoadenylate (2-5A) synthetases", "start": 4, "end": 50}, {"text": "interferon", "start": 75, "end": 85}, {"text": "IFN", "start": 87, "end": 90}, {"text": "anti-viral proteins", "start": 102, "end": 121}]}}, "schema": []}
{"input": "Our findings demonstrate a dose-dependent blockade of the mechanical sensitivity caused by a mild thermal injury by both GBP and IBG.", "output": {"entities": {}}, "schema": []}
{"input": "These striations were caused by contact between the sharp edge of the upper canine and the P3 during honing (canine/premolar complex).", "output": {"entities": {}}, "schema": []}
{"input": "Low PbrO2 readings, however, could be caused by local microhemorrhages, undetectable on CT or MRI.", "output": {"entities": {}}, "schema": []}
{"input": "The consequences of intensive swine production on the environment and possible solutions by means of nutrition are outlined.", "output": {"entities": {}}, "schema": []}
{"input": "This study demonstrates that alteration of CDKN2 is one of the most frequent genetic abnormalities in prostate cancer and may contribute to prostate carcinogenesis.", "output": {"entities": {"gene": [{"text": "CDKN2", "start": 43, "end": 48}]}}, "schema": []}
{"input": "The pharmacokinetic parameters which helped predict these toxicities included area under the curve and peak plasma level.", "output": {"entities": {}}, "schema": []}
{"input": "A Chinese (HK) SF-36 survey form was developed by an iterative translation process.", "output": {"entities": {}}, "schema": []}
{"input": "However, the use of cyclosporin A is associated with an increased prevalence of hypertension in kidney transplant recipients.", "output": {"entities": {}}, "schema": []}
{"input": "PURPOSE: To determine the effects of hypercholesterolemia and atherosclerosis-induced chronic cavernosal arterial insufficiency on cavernosal smooth muscle tone, nitric oxide synthase (NOS) activity and cavernosal tissue synthesis of constrictor eicosanoids.", "output": {"entities": {"gene": [{"text": "nitric oxide synthase", "start": 162, "end": 183}, {"text": "NOS", "start": 185, "end": 188}]}}, "schema": []}
{"input": "Characterization of the regulatory regions of the human aromatase (P450arom) gene involved in placenta-specific expression.", "output": {"entities": {"gene": [{"text": "human aromatase", "start": 50, "end": 65}, {"text": "P450arom", "start": 67, "end": 75}]}}, "schema": []}
{"input": "Recombinant FVIIa was stable in the infusion pump for several days at room temperature and for 24 h at body temperature.", "output": {"entities": {"gene": [{"text": "Recombinant FVIIa", "start": 0, "end": 17}]}}, "schema": []}
{"input": "(1992) Biochemistry 31, 3351-3358].", "output": {"entities": {}}, "schema": []}
{"input": "Levels of serum IgE were measured monthly, and nasal IgE was measured at the height and end of the season.", "output": {"entities": {"gene": [{"text": "IgE", "start": 16, "end": 19}, {"text": "IgE", "start": 53, "end": 56}]}}, "schema": []}
{"input": "A mutation in the 5' C2U4 repeat causes underaccumulation of snR13F, whereas mutations in the 3' C2U4 repeat cause the accumulation of two novel RNAs that migrate in the 500-nt range.", "output": {"entities": {"gene": [{"text": "snR13F", "start": 61, "end": 67}]}}, "schema": []}
{"input": "By directly interacting with both Arfs and tyrosine kinases involved in regulating cell growth and cytoskeletal organization, ASAP1 could coordinate membrane remodeling events with these processes.", "output": {"entities": {"gene": [{"text": "Arfs", "start": 34, "end": 38}, {"text": "tyrosine kinases", "start": 43, "end": 59}, {"text": "ASAP1", "start": 126, "end": 131}]}}, "schema": []}
{"input": "These sorting nexins also associated with the long isoform of the leptin receptor but not with the short and medium isoforms.", "output": {"entities": {"gene": [{"text": "sorting nexins", "start": 6, "end": 20}, {"text": "leptin receptor", "start": 66, "end": 81}]}}, "schema": []}
{"input": "Cyclophilins are cis-trans-peptidyl-prolyl isomerases that bind to and are inhibited by the immunosuppressant cyclosporin A (CsA).", "output": {"entities": {"gene": [{"text": "Cyclophilins", "start": 0, "end": 12}, {"text": "cis-trans-peptidyl-prolyl isomerases", "start": 17, "end": 53}]}}, "schema": []}
{"input": "In vitro protein retention experiments in which Hsp90 heterocomplexes were precipitated resulted in coprecipitation of Cns1.", "output": {"entities": {"gene": [{"text": "Hsp90 heterocomplexes", "start": 48, "end": 69}, {"text": "Cns1", "start": 119, "end": 123}]}}, "schema": []}
{"input": "The Ras-related GTPases are small, 20-to 25-kDa proteins which cycle between an inactive GDP-bound form and an active GTP-bound state.", "output": {"entities": {"gene": [{"text": "Ras-related GTPases", "start": 4, "end": 23}]}}, "schema": []}
{"input": "To modulate transcription, regulatory factors communicate with basal transcription factors and/or RNA polymerases in a variety of ways.", "output": {"entities": {"gene": [{"text": "RNA polymerases", "start": 98, "end": 113}]}}, "schema": []}
{"input": "Endogenous RMP was immunologically detected interacting with assembled RPB5 in RNA polymerase in mammalian cells.", "output": {"entities": {"gene": [{"text": "RMP", "start": 11, "end": 14}, {"text": "RPB5", "start": 71, "end": 75}, {"text": "RNA polymerase", "start": 79, "end": 93}]}}, "schema": []}
{"input": "In this study, rabbits were used to evaluate the sutured wound reaction with Dexon or nylon in the conjunctival flap 1, 4, 7, 14 and 28 days after trabeculectomy surgery with or without the use of mitomycin-C.", "output": {"entities": {}}, "schema": []}
{"input": "The mapping was completed with Southern blotting and restriction analysis.", "output": {"entities": {}}, "schema": []}
{"input": "The zona pellucida (ZP), the extracellular glycocalyx that surrounds the oocyte, is well known to mediate homologous gamete interaction.", "output": {"entities": {}}, "schema": []}
{"input": "Therapeutic use of continuous subcutaneous infusion of recombinant human erythropoietin in malnourished predialysis anemic patients with diabetic nephropathy.", "output": {"entities": {"gene": [{"text": "recombinant human erythropoietin", "start": 55, "end": 87}]}}, "schema": []}
{"input": "Although pathological thyroid function is related to changes in energy expenditure and body composition, its possible influence on leptin levels remains to be determined.", "output": {"entities": {"gene": [{"text": "leptin", "start": 131, "end": 137}]}}, "schema": []}
{"input": "These cognitive deficits were prevented in animals treated with MK-801 during SE.", "output": {"entities": {}}, "schema": []}
{"input": "Here we demonstrate that the mechanism of activation of HIF-1alpha is a multi-step process which includes hypoxia-dependent nuclear import and activation (derepression) of the transactivation domain, resulting in recruitment of the CREB-binding protein (CBP)/p300 coactivator.", "output": {"entities": {"gene": [{"text": "HIF-1alpha", "start": 56, "end": 66}, {"text": "CREB-binding protein", "start": 232, "end": 252}, {"text": "CBP", "start": 254, "end": 257}, {"text": "p300 coactivator", "start": 259, "end": 275}]}}, "schema": []}
{"input": "Thus, hypoxia-inducible nuclear import and transactivation by recruitment of CBP can be functionally separated from one another and play critical roles in signal transduction by HIF-1alpha.", "output": {"entities": {"gene": [{"text": "CBP", "start": 77, "end": 80}, {"text": "HIF-1alpha", "start": 178, "end": 188}]}}, "schema": []}
{"input": "The rat aldolase C gene encodes a glycolytic enzyme strongly expressed in adult brain.", "output": {"entities": {"gene": [{"text": "rat aldolase C gene", "start": 4, "end": 23}]}}, "schema": []}
{"input": "A synergistic effect on HCK promoter activity was observed at high concentrations of Sp1.", "output": {"entities": {"gene": [{"text": "HCK promoter", "start": 24, "end": 36}, {"text": "Sp1", "start": 85, "end": 88}]}}, "schema": []}
{"input": "Quinone-binding domain and amino acid residues involved in quinone binding.", "output": {"entities": {}}, "schema": []}
{"input": "Western analyses with antisera raised against Lu-ECAM-1 peptides show that the N-terminal region of the predicted open reading frame is present only in the larger size proteins (i. e.", "output": {"entities": {"gene": [{"text": "Lu-ECAM-1 peptides", "start": 46, "end": 64}]}}, "schema": []}
{"input": "Mammalian sperm motility is regulated by a cascade of cAMP-dependent protein phosphorylation events mediated by protein kinase A.", "output": {"entities": {"gene": [{"text": "protein kinase A", "start": 112, "end": 128}]}}, "schema": []}
{"input": "In this paper, we show that, like BAP2, the expression of the BAP3 gene in S. cerevisiae is induced by the addition of branched-chain amino acids to the medium.", "output": {"entities": {"gene": [{"text": "BAP2", "start": 34, "end": 38}, {"text": "BAP3 gene", "start": 62, "end": 71}]}}, "schema": []}
{"input": "Effect of enteral nutritional products differing in carbohydrate and fat on indices of carbohydrate and lipid metabolism in patients with NIDDM.", "output": {"entities": {}}, "schema": []}
{"input": "Low-grade gastric MALT lymphoma and helicobacter heilmannii (Gastrospirillum hominis", "output": {"entities": {}}, "schema": []}
{"input": "These studies support the view that HMG I (Y) is an important cofactor for HLA-DRA gene activation by Oct-2A and provide insights into its mechanism of action.", "output": {"entities": {"gene": [{"text": "HMG I (Y)", "start": 36, "end": 45}, {"text": "HLA-DRA gene", "start": 75, "end": 87}, {"text": "Oct-2A", "start": 102, "end": 108}]}}, "schema": []}
{"input": "In contrast to hemodynamic and histopathological predictors of survival, vWF: Ag does not require invasive techniques to be determined.", "output": {"entities": {"gene": [{"text": "vWF", "start": 73, "end": 76}]}}, "schema": []}
{"input": "CONCLUSION: We were unable to identify features of disease likely to be associated with a clinically useful response to inhaled NO therapy using the parameters studied.", "output": {"entities": {}}, "schema": []}
{"input": "We find that BCL-6 POZ domain mutations that disrupt the interaction with N-CoR and SMRT no longer repress transcription.", "output": {"entities": {"gene": [{"text": "BCL-6", "start": 13, "end": 18}, {"text": "N-CoR", "start": 74, "end": 79}, {"text": "SMRT", "start": 84, "end": 88}]}}, "schema": []}
{"input": "Partial characterization of the active site human platelet cAMP phosphodiesterase, PDE3A, by site-directed mutagenesis.", "output": {"entities": {"gene": [{"text": "human platelet cAMP phosphodiesterase", "start": 44, "end": 81}, {"text": "PDE3A", "start": 83, "end": 88}]}}, "schema": []}
{"input": "This core sequence, along with additional nonspecific downstream nucleotides, is sufficient for partial suppression of spliceosome assembly and splicing of BPV-1 pre-mRNAs.", "output": {"entities": {}}, "schema": []}
{"input": "Over-expression of the cofactor p300, which functions as a coactivator of myoD-mediated transcription, alleviated repression by COUP-TF II.", "output": {"entities": {"gene": [{"text": "p300", "start": 32, "end": 36}, {"text": "myoD", "start": 74, "end": 78}, {"text": "COUP-TF II", "start": 128, "end": 138}]}}, "schema": []}
{"input": "Familial autoimmune hepatitis and C4 deficiency", "output": {"entities": {"gene": [{"text": "C4", "start": 34, "end": 36}]}}, "schema": []}
{"input": "Since glutathione peroxidase (GPX) and superoxide dismutase (SOD) play a significant role in erythrocyte antioxidative defence, it is very important to determine their activity in occupationally exposed workers.", "output": {"entities": {"gene": [{"text": "glutathione peroxidase", "start": 6, "end": 28}, {"text": "GPX", "start": 30, "end": 33}, {"text": "superoxide dismutase", "start": 39, "end": 59}, {"text": "SOD", "start": 61, "end": 64}]}}, "schema": []}
{"input": "Retroviral nucleocapsid proteins (NCPs) are CCHC-type zinc finger proteins that mediate virion RNA binding activities associated with retrovirus assembly and genomic RNA encapsidation.", "output": {"entities": {"gene": [{"text": "Retroviral nucleocapsid proteins", "start": 0, "end": 32}, {"text": "NCPs", "start": 34, "end": 38}, {"text": "CCHC-type zinc finger proteins", "start": 44, "end": 74}]}}, "schema": []}
{"input": "The Schizosaccharomyces pombe rad1 + cell cycle checkpoint control gene is required for S-phase and G2/M arrest in response to both DNA damage and incomplete DNA replication.", "output": {"entities": {"gene": [{"text": "Schizosaccharomyces pombe rad1 + cell cycle checkpoint control gene", "start": 4, "end": 71}]}}, "schema": []}
{"input": "It is now well established that progression through the eukaryotic cell cycle is controlled by oscillations in the activity of cyclin-dependent kinases (CDKs).", "output": {"entities": {"gene": [{"text": "cyclin-dependent kinases", "start": 127, "end": 151}, {"text": "CDKs", "start": 153, "end": 157}]}}, "schema": []}
{"input": "Positive genetic selections for inhibition of cyclin/CDK function were characterized using the E. coli neo and yeast LEU2 genes.", "output": {"entities": {"gene": [{"text": "cyclin", "start": 46, "end": 52}, {"text": "CDK", "start": 53, "end": 56}, {"text": "E. coli neo", "start": 95, "end": 106}, {"text": "yeast LEU2 genes", "start": 111, "end": 127}]}}, "schema": []}
{"input": "The hematopoietic colony-stimulating factors (CSF) have been introduced into clinical practice as additional supportive measures that can reduce the incidence of infectious complications in patients with cancer and neutropenia.", "output": {"entities": {"gene": [{"text": "hematopoietic colony-stimulating factors", "start": 4, "end": 44}, {"text": "CSF", "start": 46, "end": 49}]}}, "schema": []}
{"input": "All injections of CSF were given after the initiation of neutropenia and continued until the occurrence of an absolute neutrophil recovery. rHu GM-CSF and rHu G-CSF, administered once daily at the 250 microg m (-2) day (-1) and 5 microg kg (-1) day (-1) level, were effective in increasing the absolute neutrophil count and neutrophil function, as measured by an automated chemiluminescence system.", "output": {"entities": {"gene": [{"text": "CSF", "start": 18, "end": 21}, {"text": "rHu GM-CSF", "start": 140, "end": 150}, {"text": "rHu G-CSF", "start": 155, "end": 164}]}}, "schema": []}
{"input": "We evaluated regional right ventricular wall motion during systole in patients with surgically repaired tetralogy of Fallot (TOF) using color kinesis imaging.", "output": {"entities": {}}, "schema": []}
{"input": "Interestingly, we find that the interaction between Tat and hCycT1 requires zinc as well as essential cysteine residues in both proteins.", "output": {"entities": {"gene": [{"text": "Tat", "start": 52, "end": 55}, {"text": "hCycT1", "start": 60, "end": 66}]}}, "schema": []}
{"input": "During early neurogenesis, Vnd protein is restricted to ventral column neuroectoderm and neuroblasts; later it is detected in a complex pattern of neurons.", "output": {"entities": {"gene": [{"text": "Vnd protein", "start": 27, "end": 38}]}}, "schema": []}
{"input": "The repression domain, and indeed the entire Cdc68 protein, is highly conserved, as shown by the sequence of the Cdc68 functional homolog from the yeast Kluyveromyces lactis and by database searches.", "output": {"entities": {"gene": [{"text": "Cdc68 protein", "start": 45, "end": 58}, {"text": "Cdc68 functional homolog", "start": 113, "end": 137}]}}, "schema": []}
{"input": "The exodomain alone has the high affinity hormone binding site but is not capable of generating hormonal signal.", "output": {"entities": {}}, "schema": []}
{"input": "Pyrrolidine dithiocarbamate, a potent transcriptional inhibitor of the viral LTR, abrogated the cytokine responses in both U1 and ACH-2 cells, suggesting a common TNF-alpha-mediated transcriptional mechanism in these cell types despite their different modes of provirus latency.", "output": {"entities": {"gene": [{"text": "viral LTR", "start": 71, "end": 80}, {"text": "TNF-alpha", "start": 163, "end": 172}]}}, "schema": []}
{"input": "Furthermore, synergistic activation of ERK2 occurred in the absence of changes in intracellular Ca2 +, and was not blocked by inhibition of protein kinase C activity and represents a separate pathway by which CD19 regulates B cell function.", "output": {"entities": {"gene": [{"text": "ERK2", "start": 39, "end": 43}, {"text": "protein kinase C", "start": 140, "end": 156}, {"text": "CD19", "start": 209, "end": 213}]}}, "schema": []}
{"input": "The retrovesical hydatid cyst is a very rare site.", "output": {"entities": {}}, "schema": []}
{"input": "Biochemical analysis reveals that KS1 is a nuclear protein containing two transcriptional repressor domains, R1 and R2.", "output": {"entities": {"gene": [{"text": "KS1", "start": 34, "end": 37}]}}, "schema": []}
{"input": "However, the BCH group showed inferior gross motor performance on the Bruininks-Oseretsky Test of Motor Proficiency (Bruininks 1978).", "output": {"entities": {}}, "schema": []}
{"input": "We report here that, for a constant amount of transfected DNA, the level of chloramphenicol acetyltransferase (CAT) mRNA is increased in Vpr-expressing cells using either HIV-1 or a murine leukemia virus (MLV) SL3-3 LTR-CAT reporter construct.", "output": {"entities": {"gene": [{"text": "chloramphenicol acetyltransferase", "start": 76, "end": 109}, {"text": "CAT", "start": 111, "end": 114}, {"text": "Vpr", "start": 137, "end": 140}, {"text": "leukemia virus (MLV) SL3-3 LTR", "start": 189, "end": 219}, {"text": "CAT", "start": 220, "end": 223}]}}, "schema": []}
{"input": "We identified telSMN mutations in 11 of these unrelated SMA-like individuals who carry a single copy of telSMN: these include two frameshift mutations (800ins11 and 542delGT) and three missense mutations (A2G, S262I, and T274I).", "output": {"entities": {"gene": [{"text": "telSMN", "start": 14, "end": 20}, {"text": "telSMN", "start": 104, "end": 110}]}}, "schema": []}
{"input": "The decrease of TNF receptors by IL-4 was accompanied by down-regulation of TNF-induced activities, including cytotoxicity, caspase-3 activation, NF-kappaB and AP-1 activation, and c-Jun N-terminal kinase induction.", "output": {"entities": {"gene": [{"text": "TNF receptors", "start": 16, "end": 29}, {"text": "IL-4", "start": 33, "end": 37}, {"text": "TNF", "start": 76, "end": 79}, {"text": "caspase-3", "start": 124, "end": 133}, {"text": "NF-kappaB", "start": 146, "end": 155}, {"text": "AP-1", "start": 160, "end": 164}, {"text": "c-Jun N-terminal kinase", "start": 181, "end": 204}]}}, "schema": []}
{"input": "Type 2 deiodinase (D2) catalyzes the 5'-deiodination of thyroxine to form 3, 5, 3'-triiodothyronine.", "output": {"entities": {"gene": [{"text": "Type 2 deiodinase", "start": 0, "end": 17}, {"text": "D2", "start": 19, "end": 21}]}}, "schema": []}
{"input": "We have identified two overlapping expressed sequence tag clones, which contain the missing 4. 4-kb 3'-UTR of the human D2 (hD2) cDNA.", "output": {"entities": {"gene": [{"text": "human D2", "start": 114, "end": 122}, {"text": "hD2", "start": 124, "end": 127}]}}, "schema": []}
{"input": "Biol.", "output": {"entities": {}}, "schema": []}
{"input": "Here we have investigated the structural requirements and consequences of regulatory phosphorylation for the interaction between c-Jun and JNK in vivo.", "output": {"entities": {"gene": [{"text": "c-Jun", "start": 129, "end": 134}, {"text": "JNK", "start": 139, "end": 142}]}}, "schema": []}
{"input": "Immunolocalization of Sop1p revealed a cytoplasmic distribution and cell fractionation studies showed that a significant fraction of Sop1p was recovered in a sedimentable fraction of the cytosolic material.", "output": {"entities": {"gene": [{"text": "Sop1p", "start": 22, "end": 27}, {"text": "Sop1p", "start": 133, "end": 138}]}}, "schema": []}
{"input": "Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK).", "output": {"entities": {"gene": [{"text": "c-Jun N-terminal kinase", "start": 24, "end": 47}, {"text": "stress-activated protein kinase", "start": 48, "end": 79}, {"text": "JNK", "start": 81, "end": 84}, {"text": "SAPK", "start": 85, "end": 89}]}}, "schema": []}
{"input": "Here we report the full-length coding cDNA sequence of the mouse homologue of MPP3.", "output": {"entities": {"gene": [{"text": "mouse homologue of MPP3", "start": 59, "end": 82}]}}, "schema": []}
{"input": "The method also eliminates tagging of venous spins and concern about asymmetric magnetization transfer effects.", "output": {"entities": {}}, "schema": []}
{"input": "Consistent with this, purified Dlk phosphorylated core histones H3, H2A and H4 as exogenous substrates and endogenous histone H3 in kinase assays with nuclear extracts.", "output": {"entities": {"gene": [{"text": "Dlk", "start": 31, "end": 34}, {"text": "histones H3", "start": 55, "end": 66}, {"text": "H2A", "start": 68, "end": 71}, {"text": "H4", "start": 76, "end": 78}, {"text": "histone H3", "start": 118, "end": 128}]}}, "schema": []}
{"input": "Neither Ha-Ras (G12V, T35S) (Ha-RasV12S35), which activates the Rafl signaling pathway, nor Ha-Ras (G12V, E37G) (Ha-RasV12G37), which stimulates the RalGDS pathway, did not have significant effects on factor-withdrawal apoptosis of myeloid cells.", "output": {"entities": {"gene": [{"text": "Ha-Ras", "start": 8, "end": 14}, {"text": "Ha-RasV12S35", "start": 29, "end": 41}, {"text": "Rafl", "start": 64, "end": 68}, {"text": "Ha-Ras (G12V, E37G)", "start": 92, "end": 111}, {"text": "Ha-RasV12G37", "start": 113, "end": 125}, {"text": "RalGDS", "start": 149, "end": 155}]}}, "schema": []}
{"input": "We have isolated a novel human cyclin, cyclin E2, that contains significant homology to cyclin E.", "output": {"entities": {"gene": [{"text": "human cyclin", "start": 25, "end": 37}, {"text": "cyclin E2", "start": 39, "end": 48}, {"text": "cyclin E", "start": 88, "end": 96}]}}, "schema": []}
{"input": "Initial experience with the new technology indicates that SieScape is an alternative to other methods such as CT and MRI.", "output": {"entities": {}}, "schema": []}
{"input": "The dopamine D4 receptor as well as many other catecholaminergic receptors contain several putative SH3 binding domains.", "output": {"entities": {"gene": [{"text": "dopamine D4 receptor", "start": 4, "end": 24}, {"text": "catecholaminergic receptors", "start": 47, "end": 74}, {"text": "SH3 binding domains", "start": 100, "end": 119}]}}, "schema": []}
{"input": "Schizosaccharomyces pombe cells respond to nutrient deprivation by altering G2/M cell size control.", "output": {"entities": {}}, "schema": []}
{"input": "A-tracts functioned best when positioned close to the-35 hexamer rather than one helical turn farther upstream, similar to the positioning optimal for UP element function.", "output": {"entities": {}}, "schema": []}
{"input": "Pyk2 phosphorylation increased upon adherence of FLG 29. 1 cells to fibronectin and to ST2 stromal cells.", "output": {"entities": {"gene": [{"text": "Pyk2", "start": 0, "end": 4}, {"text": "fibronectin", "start": 68, "end": 79}]}}, "schema": []}
{"input": "Raf is a key serine-threonine protein kinase which participates in the transmission of growth, anti-apoptotic and differentiation messages.", "output": {"entities": {"gene": [{"text": "Raf", "start": 0, "end": 3}, {"text": "serine-threonine protein kinase", "start": 13, "end": 44}]}}, "schema": []}
{"input": "The US National Institute on Alcohol Abuse and Alcoholism (NIAAA) recognizes two forms of problematic drinking:' willful alcohol abuse', a behavioural problem, and' alcohol dependence', a true medical disorder, which includes a genetic component, that can be scientifically understood and medically treated.", "output": {"entities": {}}, "schema": []}
{"input": "Collagen was extracted from the skin, and the lack of type III collagen was determined by means of sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE).", "output": {"entities": {"gene": [{"text": "Collagen", "start": 0, "end": 8}, {"text": "type III collagen", "start": 54, "end": 71}]}}, "schema": []}
{"input": "RESULTS: During the 7-year period, 10, 331 symptomatic duodenal ulcer diseases were diagnosed.", "output": {"entities": {}}, "schema": []}
{"input": "In turn, assembly of this complex mediates the enzymatic activation of the p21-activated protein kinase 1 and facilitates actin polymerization.", "output": {"entities": {"gene": [{"text": "p21-activated protein kinase 1", "start": 75, "end": 105}, {"text": "actin", "start": 122, "end": 127}]}}, "schema": []}
{"input": "Jembrana disease virus (JDV) is a newly identified bovine lentivirus that is closely related to the bovine immunodeficiency virus (BIV).", "output": {"entities": {}}, "schema": []}
{"input": "Approximately 50% of the residues are conserved among all three sequences, yet all three viruses have retained response elements for glucocorticoids, two positionally conserved CCAAT boxes, and positionally conserved TATA boxes.", "output": {"entities": {}}, "schema": []}
{"input": "Nhp2p is a highly basic protein that belongs to a family of putative RNA-binding proteins.", "output": {"entities": {"gene": [{"text": "Nhp2p", "start": 0, "end": 5}]}}, "schema": []}
{"input": "This survey included 3000 randomly selected Norwegians above 18 years of age who received the European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30 (+ 3) by mail.", "output": {"entities": {}}, "schema": []}
{"input": "During presentation of happy facial expressions, we detected a signal increase predominantly in the left anterior cingulate gyrus, bilateral posterior cingulate gyri, medial frontal cortex and right supramarginal gyrus, brain regions previously implicated in visuospatial and emotion processing tasks.", "output": {"entities": {}}, "schema": []}
{"input": "Down-regulation of IRS-1 is linked to its serine phosphorylation dependent on PI 3-kinase activity and appears required for differentiation to occur, as IRS-1 is not modified and continues to accumulate in a nondifferentiating myoblast cell line.", "output": {"entities": {"gene": [{"text": "IRS-1", "start": 19, "end": 24}, {"text": "PI 3-kinase", "start": 78, "end": 89}, {"text": "IRS-1", "start": 153, "end": 158}]}}, "schema": []}
{"input": "This study utilizes the mammalian two-hybrid system to examine the role of ligand in the dimerization of human progesterone receptor (hPR).", "output": {"entities": {"gene": [{"text": "human progesterone receptor", "start": 105, "end": 132}, {"text": "hPR", "start": 134, "end": 137}]}}, "schema": []}
{"input": "One of its unique features appears to be the unusually short 5'-untranslated regions (UTR) (1-6 nucleotides (nts)) and the apparent absence of 5'-cap structures from its mRNAs.", "output": {"entities": {}}, "schema": []}
{"input": "The gene encoding human tissue-type plasminogen activator (t-PA) is regulated in a cell-type-specific manner.", "output": {"entities": {"gene": [{"text": "gene encoding human tissue-type plasminogen activator", "start": 4, "end": 57}, {"text": "t-PA", "start": 59, "end": 63}]}}, "schema": []}
{"input": "Both the presence of arginine and anaerobiosis are needed to trigger induction of the pathway.", "output": {"entities": {}}, "schema": []}
{"input": "Competition with a putative MADS box consensus binding site from the promoter of the coordinately regulated opaque-phase-specific gene PEP1 (SAP1) and the human MADS box consensus binding site for serum response factor demonstrated that one of the three complexes formed was specific to the OP4 sequence.", "output": {"entities": {"gene": [{"text": "MADS box", "start": 28, "end": 36}, {"text": "opaque-phase-specific gene PEP1", "start": 108, "end": 139}, {"text": "SAP1", "start": 141, "end": 145}, {"text": "human MADS box consensus binding site", "start": 155, "end": 192}, {"text": "serum response factor", "start": 197, "end": 218}, {"text": "OP4 sequence", "start": 291, "end": 303}]}}, "schema": []}
{"input": "The human SHBG proximal promoter was analyzed by DNase I footprinting, and the functional significance of 6 footprinted regions (FP1-FP6) within the proximal promoter was studied in human HepG2 hepatoblastoma cells.", "output": {"entities": {"gene": [{"text": "human SHBG proximal promoter", "start": 4, "end": 32}, {"text": "DNase I", "start": 49, "end": 56}]}}, "schema": []}
{"input": "In vitro translation and in vivo polysome profile analysis indicated that transcripts C and E were translated with similar translational efficiencies that are substantially greater than that of transcript D, suggesting that 5'-untranslated regions play a role in translational control.", "output": {"entities": {"gene": [{"text": "transcripts C and E", "start": 74, "end": 93}, {"text": "transcript D", "start": 194, "end": 206}]}}, "schema": []}
{"input": "We have introduced a mutation (Ser36--> Asn) into this domain of p190 that decreased its ability to bind guanine nucleotide when expressed as a hemagglutinin (HA)-tagged protein in COS cells.", "output": {"entities": {"gene": [{"text": "p190", "start": 65, "end": 69}, {"text": "hemagglutinin", "start": 144, "end": 157}, {"text": "HA", "start": 159, "end": 161}]}}, "schema": []}
{"input": "Wild type HA-p190 induced a phenotype of rounded cells with long, beaded extensions similar to that seen when Rho function is disrupted by ADP-ribosylation.", "output": {"entities": {"gene": [{"text": "HA", "start": 10, "end": 12}, {"text": "p190", "start": 13, "end": 17}, {"text": "Rho", "start": 110, "end": 113}]}}, "schema": []}
{"input": "We emphasize that ANCA-associated vasculitis is another important complication of RA.", "output": {"entities": {"gene": [{"text": "ANCA", "start": 18, "end": 22}]}}, "schema": []}
{"input": "The downstream, TATA-less promoter has high G + C content, and exon 1b predominates among abundantly expressed mRNA species.", "output": {"entities": {}}, "schema": []}
{"input": "Although we predicted that overexpression of the COOH-terminal domains, which were thought to be involved in the regulation of SREBP processing, would result in disruption of the SREBP-dependent transcriptional regulation of several genes, the mRNA levels for 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) synthase in these two cell lines were regulated in a sterol-dependent manner.", "output": {"entities": {"gene": [{"text": "SREBP", "start": 127, "end": 132}, {"text": "SREBP", "start": 179, "end": 184}, {"text": "3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) synthase", "start": 260, "end": 316}]}}, "schema": []}
{"input": "Dry matter intake, apparent nutrient digestibilities, serum chemistry profiles, sphingolipid concentrations, and persistency of FB1 in tissues were evaluated.", "output": {"entities": {}}, "schema": []}
{"input": "However, no studies have been conducted to further investigate this potentially hazardous effect of lidocaine.", "output": {"entities": {}}, "schema": []}
{"input": "E., Scott, J.", "output": {"entities": {}}, "schema": []}
{"input": "Yap1p is constitutively nuclear in a crm1 mutant, and Crm1p binds to a nuclear export sequence (NES)-like sequence in Yap1p in the presence of RanGTP.", "output": {"entities": {"gene": [{"text": "Yap1p", "start": 0, "end": 5}, {"text": "crm1 mutant", "start": 37, "end": 48}, {"text": "Crm1p", "start": 54, "end": 59}, {"text": "Yap1p", "start": 118, "end": 123}, {"text": "RanGTP", "start": 143, "end": 149}]}}, "schema": []}
{"input": "Mean intake of vitamin A amounted to 1. 1 and 0. 9 mg RE/day for men and women, respectively; the contributions of meat, fats and oils, vegetables and dairy products to total intake were 35%, 24%, 16%, and 16%, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, RING1 overexpression results in enhanced expression of the proto-oncogenes c-jun and c-fos.", "output": {"entities": {"gene": [{"text": "RING1", "start": 13, "end": 18}, {"text": "c-jun", "start": 88, "end": 93}, {"text": "c-fos", "start": 98, "end": 103}]}}, "schema": []}
{"input": "The yeast RER2 gene, identified by endoplasmic reticulum protein localization mutations, encodes cis-prenyltransferase, a key enzyme in dolichol synthesis.", "output": {"entities": {"gene": [{"text": "yeast RER2 gene", "start": 4, "end": 19}, {"text": "cis-prenyltransferase", "start": 97, "end": 118}]}}, "schema": []}
{"input": "The yeast retrotransposon Ty5 preferentially integrates into regions of silent chromatin.", "output": {"entities": {"gene": [{"text": "retrotransposon Ty5", "start": 10, "end": 29}]}}, "schema": []}
{"input": "The loss of SKO1 completely restored ENA1 expression in a hog1 mutant and partially suppressed the osmotic stress sensitivity, qualifying Sko1p as a downstream effector of the HOG pathway.", "output": {"entities": {"gene": [{"text": "SKO1", "start": 12, "end": 16}, {"text": "ENA1", "start": 37, "end": 41}, {"text": "hog1 mutant", "start": 58, "end": 69}, {"text": "Sko1p", "start": 138, "end": 143}, {"text": "HOG", "start": 176, "end": 179}]}}, "schema": []}
{"input": "Elevated expression of a previously uncharacterized gene, SPP381, efficiently suppresses the growth and splicing defects of a temperature-sensitive (Ts) mutant prp38-1.", "output": {"entities": {"gene": [{"text": "SPP381", "start": 58, "end": 64}, {"text": "mutant prp38-1", "start": 153, "end": 167}]}}, "schema": []}
{"input": "The slower-electrophoretic-mobility form of p68 was absent in human cells in G1/S and appeared as the cells entered G2/M.", "output": {"entities": {"gene": [{"text": "p68", "start": 44, "end": 47}]}}, "schema": []}
{"input": "We have identified amino acid sequences in mammalian and Xenopus NeuroD1/BETA2 that are necessary for insulin gene expression and ectopic neurogenesis.", "output": {"entities": {"gene": [{"text": "NeuroD1", "start": 65, "end": 72}, {"text": "BETA2", "start": 73, "end": 78}, {"text": "insulin gene", "start": 102, "end": 114}]}}, "schema": []}
{"input": "Recent studies have suggested that Y319 also positively regulate ZAP-70 function.", "output": {"entities": {"gene": [{"text": "ZAP-70", "start": 65, "end": 71}]}}, "schema": []}
{"input": "Genetic and molecular data indicate that wild-type Pan and CiD compete for binding to Arm, leading to a compromised transduction of the Wg signal in heterozygous ciD/+ animals and to a dramatic enhancement of the gain-of-function activity of CiD in homozygous mutants.", "output": {"entities": {"gene": [{"text": "wild-type Pan", "start": 41, "end": 54}, {"text": "CiD", "start": 59, "end": 62}, {"text": "Arm", "start": 86, "end": 89}, {"text": "Wg", "start": 136, "end": 138}, {"text": "ciD/+", "start": 162, "end": 167}, {"text": "CiD", "start": 242, "end": 245}]}}, "schema": []}
{"input": "Another ORF, dda. 2 located between modA and dda, shares sequence similarity with sigma70, and we call it srd.", "output": {"entities": {"gene": [{"text": "dda. 2", "start": 13, "end": 19}, {"text": "modA", "start": 36, "end": 40}, {"text": "dda", "start": 45, "end": 48}, {"text": "sigma70", "start": 82, "end": 89}, {"text": "srd", "start": 106, "end": 109}]}}, "schema": []}
{"input": "The location of the IBS within the catB structural gene, the cooperativity observed in footprinting studies and phasing studies suggest that the IBS participates in the interaction of CatR with the upstream binding sites by looping out the intervening DNA.", "output": {"entities": {"gene": [{"text": "catB structural gene", "start": 35, "end": 55}, {"text": "CatR", "start": 184, "end": 188}]}}, "schema": []}
{"input": "In vitro transcription assays demonstrate that the TCA-cycle intermediate, fumarate, directly and specifically inhibits the formation of the clcA transcript.", "output": {"entities": {"gene": [{"text": "clcA transcript", "start": 141, "end": 156}]}}, "schema": []}
{"input": "BIAcore analysis gave a Kaff of 4. 4 x 10 (10) M-1 for the binding of N-A3 to T84. 1 and 2. 2 x 10 (10) M-1 for the binding of N-A3 to T84. 66.", "output": {"entities": {"gene": [{"text": "N-A3", "start": 70, "end": 74}, {"text": "T84. 1", "start": 78, "end": 84}, {"text": "N-A3", "start": 127, "end": 131}, {"text": "T84. 66", "start": 135, "end": 142}]}}, "schema": []}
{"input": "Expression of p130 (Cas) (Cas), a major binding protein for the Crk SH2-domain, also induced JNK activation, which was blocked by the SH2-mutant of Crk.", "output": {"entities": {"gene": [{"text": "p130", "start": 14, "end": 18}, {"text": "Cas", "start": 20, "end": 23}, {"text": "Cas", "start": 26, "end": 29}, {"text": "Crk SH2-domain", "start": 64, "end": 78}, {"text": "JNK", "start": 93, "end": 96}, {"text": "SH2-mutant", "start": 134, "end": 144}, {"text": "Crk", "start": 148, "end": 151}]}}, "schema": []}
{"input": "Positive correlations were seen between the measurements for protein intake (r =. 58, P =. 0026) energy intake (r =. 78, P <. 00001), with mean differences of. 066 g/kg/d (SD. 38) 2. 04 kcal/kg/day (SD 6. 67), respectively.", "output": {"entities": {}}, "schema": []}
{"input": "The Og4C3 enzyme-linked immunosorbent assay (ELISA) to detect circulating Wuchereria bancrofti antigen uses 50 microL of serum.", "output": {"entities": {"gene": [{"text": "Og4C3", "start": 4, "end": 9}, {"text": "Wuchereria bancrofti antigen", "start": 74, "end": 102}]}}, "schema": []}
{"input": "We now show that gp200-MR6 ligation can also mimic IL-4 and have an anti-proliferative pro-maturational influence within the immune system, causing up-regulation of co-stimulatory molecules on B lymphocytes.", "output": {"entities": {"gene": [{"text": "gp200", "start": 17, "end": 22}, {"text": "MR6", "start": 23, "end": 26}, {"text": "IL-4", "start": 51, "end": 55}]}}, "schema": []}
{"input": "The Mig1 repressor is a zinc finger protein that mediates glucose repression in yeast.", "output": {"entities": {"gene": [{"text": "Mig1 repressor", "start": 4, "end": 18}, {"text": "zinc finger protein", "start": 24, "end": 43}]}}, "schema": []}
{"input": "Recurrent arterial thrombotic disease on young onset and protein S deficiency.", "output": {"entities": {"gene": [{"text": "protein S", "start": 57, "end": 66}]}}, "schema": []}
{"input": "We showed that Stat3 and Stat3beta were affinity purified using phosphopeptides containing Y704 and Y744 but not by nonphosphorylated peptide analogues or by phosphopeptides containing Y729 and Y764.", "output": {"entities": {"gene": [{"text": "Stat3", "start": 15, "end": 20}, {"text": "Stat3beta", "start": 25, "end": 34}]}}, "schema": []}
{"input": "Taken together, our results indicate that the FCR1 gene behaves as a negative regulator of drug resistance in C. albicans and constitute the first evidence that FCZ resistance can result from the inactivation of a regulatory factor such as Fcr1p.", "output": {"entities": {"gene": [{"text": "FCR1 gene", "start": 46, "end": 55}, {"text": "Fcr1p", "start": 240, "end": 245}]}}, "schema": []}
{"input": "These findings suggest that late MYO/M is more useful than washout rate to assess the effect of treatment on heart failure due to DCM.", "output": {"entities": {}}, "schema": []}
{"input": "This study was undertaken to evaluate how couplers and their placement affect the ALGO2 click spectral properties.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS: Pretreatment with OCs prior to pituitary suppression in the early follicular phase decreases ovarian cyst formation, without an apparent effect on subsequent follicular recruitment or pregnancy rates.", "output": {"entities": {}}, "schema": []}
{"input": "With regard to the optimal threshold values, sensitivity and specificity were 100%/97% and 95%/95% with FDG PET, compared to 86%/92% and 77%/82% with IS, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Dorsal root ganglia neuron-specific promoter activity of the rabbit beta-galactoside alpha1, 2-fucosyltransferase gene.", "output": {"entities": {"gene": [{"text": "rabbit beta-galactoside alpha1, 2-fucosyltransferase gene", "start": 61, "end": 118}]}}, "schema": []}
{"input": "This suggests roles for both the CE1 and CE2 elements in regulating Hoxb1 gene expression during development.", "output": {"entities": {"gene": [{"text": "Hoxb1 gene", "start": 68, "end": 78}]}}, "schema": []}
{"input": "CAL gain amounted to 4. 2 +/-1. 3 mm, 60% of the defects showing CAL gain > or = 4 mm.", "output": {"entities": {}}, "schema": []}
{"input": "Lead fixation in dogs achieved with RF energy.", "output": {"entities": {}}, "schema": []}
{"input": "Further, we show that this EIA-inducible CBF/cdc2 is related to the CBF which was shown to activate the heat shock protein 70 promoter.", "output": {"entities": {"gene": [{"text": "EIA", "start": 27, "end": 30}, {"text": "cdc2", "start": 45, "end": 49}, {"text": "CBF", "start": 68, "end": 71}, {"text": "heat shock protein 70 promoter", "start": 104, "end": 134}]}}, "schema": []}
{"input": "The percutaneous absorption of clindamycin was studied in healthy male volunteers, comparing two investigative clindamycin (% w/v)/tretinoin (0. 025% w/v) gels, containing clindamycin phosphate ester and clindamycin HCl, respectively, relative to a clindamycin phosphate lotion (1% clindamycin; Dalacin T).", "output": {"entities": {}}, "schema": []}
{"input": "The BAL concentrations of the nine cytokines evaluated for the more and less affected lungs were compared: interleukin-6 (IL-6), IL-8, IL-12, tumor necrosis factor-alpha (TNF-alpha), and interferon gamma (IFN-gamma) showed significant differences (p ranged between 0.", "output": {"entities": {"gene": [{"text": "interleukin-6", "start": 107, "end": 120}, {"text": "IL-6", "start": 122, "end": 126}, {"text": "IL-8", "start": 129, "end": 133}, {"text": "IL-12", "start": 135, "end": 140}, {"text": "tumor necrosis factor-alpha", "start": 142, "end": 169}, {"text": "TNF-alpha", "start": 171, "end": 180}, {"text": "interferon gamma", "start": 187, "end": 203}, {"text": "IFN-gamma", "start": 205, "end": 214}]}}, "schema": []}
{"input": "Phosphorylation analyses indicated that inhibition of ERK-1/2 decreased okadaic acid-elevated phosphorylation of JunD and FosB.", "output": {"entities": {"gene": [{"text": "ERK-1/2", "start": 54, "end": 61}, {"text": "JunD", "start": 113, "end": 117}, {"text": "FosB", "start": 122, "end": 126}]}}, "schema": []}
{"input": "Two-way analysis of variance was used to determine whether composite knowledge score differed among patient groups.", "output": {"entities": {}}, "schema": []}
{"input": "The human pathogenic bacterium group A Streptococcus produces an extracellular cysteine protease [streptococcal pyrogenic exotoxin B (SpeB)] that is a critical virulence factor for invasive disease episodes.", "output": {"entities": {"gene": [{"text": "cysteine protease", "start": 79, "end": 96}, {"text": "streptococcal pyrogenic exotoxin B", "start": 98, "end": 132}, {"text": "SpeB", "start": 134, "end": 138}]}}, "schema": []}
{"input": "The orbitofrontal, cingulate, and anteromedial part of the dorsal premotor areas were preferentially activated by the self-initiated hand movement task (SELF).", "output": {"entities": {}}, "schema": []}
{"input": "The peroxisome biogenesis disorders (PBDs) are a set of lethal genetic diseases characterized by peroxisomal metabolic deficiencies, multisystem abnormalities, mental retardation, and premature death.", "output": {"entities": {}}, "schema": []}
{"input": "The active site includes the acidic triad Asp53 (the site of phosphorylation), Asp10 and Glu9.", "output": {"entities": {}}, "schema": []}
{"input": "In PAV-3, the E1A region is located between 1. 5 and 3. 8 map units.", "output": {"entities": {"gene": [{"text": "E1A region", "start": 14, "end": 24}]}}, "schema": []}
{"input": "Six putative MDV genome products, including one Rep and five non-Rep proteins, show high (70. 4-90. 9%) amino acid identity to the corresponding six FBNYV proteins, whereas two other Rep proteins encoded by MDV-C2 and C3 are 82. 3% and 73. 0% identical to those encoded by SCSV-C2 and C6, respectively.", "output": {"entities": {"gene": [{"text": "Rep", "start": 48, "end": 51}, {"text": "Rep", "start": 65, "end": 68}, {"text": "FBNYV proteins", "start": 149, "end": 163}, {"text": "Rep proteins", "start": 183, "end": 195}, {"text": "MDV-C2", "start": 207, "end": 213}, {"text": "C3", "start": 218, "end": 220}, {"text": "SCSV-C2", "start": 273, "end": 280}, {"text": "C6", "start": 285, "end": 287}]}}, "schema": []}
{"input": "MPO was labeled with 1 mCi 125I by a technique of self-labeling in the presence of 10 (-4) M hydrogen peroxide.", "output": {"entities": {"gene": [{"text": "MPO", "start": 0, "end": 3}]}}, "schema": []}
{"input": "It is related to a variety of mammalian Golgi-associated proteins and to the yeast Uso1p, an essential protein involved in docking of endoplasmic reticulum-derived vesicles to the cis-Golgi.", "output": {"entities": {"gene": [{"text": "Uso1p", "start": 83, "end": 88}]}}, "schema": []}
{"input": "The data indicate that Bmp2 is directly regulated by retinoic acid-bound receptors and Sp1.", "output": {"entities": {"gene": [{"text": "Bmp2", "start": 23, "end": 27}, {"text": "Sp1", "start": 87, "end": 90}]}}, "schema": []}
{"input": "Both proteins were shown to be constitutively associated with tubulin.", "output": {"entities": {"gene": [{"text": "tubulin", "start": 62, "end": 69}]}}, "schema": []}
{"input": "HEED was found to bind to MA protein in vitro, as efficiently as in vivo in yeast cells.", "output": {"entities": {"gene": [{"text": "HEED", "start": 0, "end": 4}, {"text": "MA protein", "start": 26, "end": 36}]}}, "schema": []}
{"input": "Fas-resistant DT-40 lymphoma B-cells rendered BTK-deficient through targeted disruption of the btk gene by homologous recombination knockout underwent apoptosis after Fas ligation, but wild-type DT-40 cells or BTK-deficient DT-40 cells reconstituted with wild-type human btk gene did not.", "output": {"entities": {"gene": [{"text": "Fas", "start": 0, "end": 3}, {"text": "BTK", "start": 46, "end": 49}, {"text": "btk gene", "start": 95, "end": 103}, {"text": "Fas", "start": 167, "end": 170}, {"text": "BTK", "start": 210, "end": 213}, {"text": "wild-type human btk gene", "start": 255, "end": 279}]}}, "schema": []}
{"input": "Varicella-zoster virus (VZV) glycoprotein gI is a type 1 transmembrane glycoprotein which is one component of the heterodimeric gE: gI Fc receptor complex.", "output": {"entities": {"gene": [{"text": "Varicella-zoster virus (VZV) glycoprotein gI", "start": 0, "end": 44}, {"text": "type 1 transmembrane glycoprotein", "start": 50, "end": 83}, {"text": "gE", "start": 128, "end": 130}, {"text": "gI Fc receptor", "start": 132, "end": 146}]}}, "schema": []}
{"input": "To this end, we analyzed the phosphorylation status of a universal tyrosine kinase substrate, the transforming Shc adapter protein, in fibroblasts expressing the viral oncogene.", "output": {"entities": {"gene": [{"text": "tyrosine kinase", "start": 67, "end": 82}, {"text": "Shc adapter protein", "start": 111, "end": 130}]}}, "schema": []}
{"input": "These genes were expressed in a Saccharomyces cerevisiae mutant in which the endogenous ferrochelatase gene (HEM15) had been deleted, and the phenotypes of the transformants were characterized.", "output": {"entities": {"gene": [{"text": "endogenous ferrochelatase gene", "start": 77, "end": 107}, {"text": "HEM15", "start": 109, "end": 114}]}}, "schema": []}
{"input": "In this study, evidence is presented that temporally and spatially specific mef2 expression is controlled by a complex array of cis-acting regulatory modules that are responsive to different genetic signals.", "output": {"entities": {"gene": [{"text": "mef2", "start": 76, "end": 80}]}}, "schema": []}
{"input": "Furthermore, using transgenic mouse technology we localized independent cis-regulatory elements controlling the tissue-specific expression of Pax6.", "output": {"entities": {"gene": [{"text": "Pax6", "start": 142, "end": 146}]}}, "schema": []}
{"input": "In the second experiment, a stable nickel isotope, 61Ni, was given in drinking water to 20 nickel-sensitized women and 20 age-matched controls, both groups having vesicular hand eczema of the pompholyx type.", "output": {"entities": {}}, "schema": []}
{"input": "Folded tissue and crimped collagen fibers in the tunica albuginea permit its expansion during erection.", "output": {"entities": {"gene": [{"text": "collagen", "start": 26, "end": 34}]}}, "schema": []}
{"input": "Number of patients infected with nontuberculous mycobacteria (NTM) is increasing world-wide in recent years.", "output": {"entities": {}}, "schema": []}
{"input": "Comparison of the sequences of attP, attB and bacteria-prophage junctions attL and attR showed a 26 bp common core sequence, where recombination takes place, near the 5' end of the integrase gene.", "output": {"entities": {"gene": [{"text": "attP", "start": 31, "end": 35}, {"text": "attB", "start": 37, "end": 41}, {"text": "attL", "start": 74, "end": 78}, {"text": "attR", "start": 83, "end": 87}, {"text": "integrase gene", "start": 181, "end": 195}]}}, "schema": []}
{"input": "Interferon-alpha treatment of posttransplant lymphoproliferative disorder in recipients of solid organ transplants.", "output": {"entities": {"gene": [{"text": "Interferon-alpha", "start": 0, "end": 16}]}}, "schema": []}
{"input": "Immunological testing was performed on all brewery workers and some control volunteers using skin prick testing with hops, barley, and yeast antigens as well as other nonoccupational allergens, and by determining total serum IgE levels.", "output": {"entities": {"gene": [{"text": "serum IgE", "start": 219, "end": 228}]}}, "schema": []}
{"input": "OBJECTIVE: To evaluate the accuracy of working casts for crown and bridge restorations made from twin mix putty/wash silicone elastomeric impression materials using different types of stock tray.", "output": {"entities": {}}, "schema": []}
{"input": "OBJECTIVES: To assess the ability of pretreatment and post-treatment prostate-specific antigen (PSA) measurements, clinical tumor stage, tumor grade, Gleason sum, race, age, and radiation dose to predict the recurrence of prostate cancer following external beam radiation therapy (XRT) since the introduction of PSA as a tumor marker at one tertiary care center.", "output": {"entities": {"gene": [{"text": "prostate-specific antigen", "start": 69, "end": 94}, {"text": "PSA", "start": 96, "end": 99}, {"text": "PSA", "start": 312, "end": 315}]}}, "schema": []}
{"input": "To evaluate whether the human gene is also a target of thyroid hormone we have searched for T3-responsive elements in NRGN cloned genomic fragments spanning the whole gene.", "output": {"entities": {"gene": [{"text": "NRGN", "start": 118, "end": 122}]}}, "schema": []}
{"input": "The transcriptional activity of PPARgamma is positively modulated by ligand binding and negatively regulated by phosphorylation mediated by the MEK/ERK signaling pathway.", "output": {"entities": {"gene": [{"text": "PPARgamma", "start": 32, "end": 41}, {"text": "MEK", "start": 144, "end": 147}, {"text": "ERK", "start": 148, "end": 151}]}}, "schema": []}
{"input": "BACKGROUND: Diazepam, one of the benzodiazepine group of tranquilizers, is used as an adjunctive drug for sedation and for relief of anxiety in the treatment of epilepsy.", "output": {"entities": {}}, "schema": []}
{"input": "Bioplastique granuloma presents with irregularly shaped cystic spaces of varying size containing jagged, translucent, nonbirefringent foreign bodies whereas Artecoll granuloma shows numerous round vacuoles nearly identical in size and shape enclosing round and sharply circumscribed, translucent, nonbirefringent foreign bodies.", "output": {"entities": {}}, "schema": []}
{"input": "This Tbx6-subfamily gene is likely to participate in paraxial mesoderm formation and somitogenesis in human embryo.", "output": {"entities": {"gene": [{"text": "Tbx6-subfamily gene", "start": 5, "end": 24}]}}, "schema": []}
{"input": "Structure-function analysis of the Z-DNA-binding domain Zalpha of dsRNA adenosine deaminase type I reveals similarity to the (alpha + beta) family of helix-turn-helix proteins.", "output": {"entities": {"gene": [{"text": "dsRNA adenosine deaminase type I", "start": 66, "end": 98}, {"text": "(alpha + beta) family", "start": 125, "end": 146}, {"text": "helix-turn-helix proteins", "start": 150, "end": 175}]}}, "schema": []}
{"input": "In addition, the regulation of Glvr-1 gene expression also has potential applications to gene therapy, since retroviral vectors carrying gibbon ape leukemia virus envelope proteins are used for gene delivery into different cell types.", "output": {"entities": {"gene": [{"text": "Glvr-1 gene", "start": 31, "end": 42}, {"text": "gibbon ape leukemia virus envelope proteins", "start": 137, "end": 180}]}}, "schema": []}
{"input": "Carbohydrates and glycoconjugates biophysical methods.", "output": {"entities": {}}, "schema": []}
{"input": "Molecular cloning of mouse glycolate oxidase.", "output": {"entities": {"gene": [{"text": "mouse glycolate oxidase", "start": 21, "end": 44}]}}, "schema": []}
{"input": "In such a manner, activated PKR inhibits cell growth and induces apoptosis, whereas disruption of normal PKR signaling results in unregulated cell growth.", "output": {"entities": {"gene": [{"text": "PKR", "start": 28, "end": 31}, {"text": "PKR", "start": 105, "end": 108}]}}, "schema": []}
{"input": "We isolated a ribosomal protein L18 by interaction with PKR.", "output": {"entities": {"gene": [{"text": "ribosomal protein L18", "start": 14, "end": 35}, {"text": "PKR", "start": 56, "end": 59}]}}, "schema": []}
{"input": "Processing of the polycistronic precursor requires nucleases also involved in rRNA processing, i. e., Rnt1p and Rat1p.", "output": {"entities": {"gene": [{"text": "Rnt1p", "start": 102, "end": 107}, {"text": "Rat1p", "start": 112, "end": 117}]}}, "schema": []}
{"input": "Furthermore, rhoA-mediated SRE activation was blocked by dominant negative mutants of PKC-alpha or PKC-epsilon.", "output": {"entities": {"gene": [{"text": "rhoA", "start": 13, "end": 17}, {"text": "PKC-alpha", "start": 86, "end": 95}, {"text": "PKC-epsilon", "start": 99, "end": 110}]}}, "schema": []}
{"input": "Nip7p-depleted cells exhibited the same defects as Nop8p-depleted cells, except that they accumulated 27S precursors.", "output": {"entities": {"gene": [{"text": "Nip7p", "start": 0, "end": 5}, {"text": "Nop8p", "start": 51, "end": 56}, {"text": "27S precursors", "start": 102, "end": 116}]}}, "schema": []}
{"input": "We show that the Sm-binding site and stem-loop III structures are necessary for correct 3'-end formation.", "output": {"entities": {"gene": [{"text": "Sm-binding site", "start": 17, "end": 32}]}}, "schema": []}
{"input": "Five different subtypes of spondyloarthropathy (SpA) are now recognized.", "output": {"entities": {}}, "schema": []}
{"input": "Further experiments will be required to highlight the in vivo role of ELE1 in nuclear receptor functioning.", "output": {"entities": {"gene": [{"text": "ELE1", "start": 70, "end": 74}]}}, "schema": []}
{"input": "Overexpression of PTTG in transfected NIH 3T3 cells also stimulated expression and secretion of basic fibroblast growth factor, a human pituitary tumor growth-regulating factor.", "output": {"entities": {"gene": [{"text": "PTTG", "start": 18, "end": 22}, {"text": "basic fibroblast growth factor", "start": 96, "end": 126}, {"text": "human pituitary tumor growth-regulating factor", "start": 130, "end": 176}]}}, "schema": []}
{"input": "The perifascicular connective tissue sheath is important in organising the contraction of the myocardium by preventing lateral spread of conduction and by permitting transmission of the impulse only at the termination of the purkinje fibre.", "output": {"entities": {}}, "schema": []}
{"input": "E1, a DNA helicase, collaborates with the HPV E2 protein in ori-dependent replication.", "output": {"entities": {"gene": [{"text": "E1", "start": 0, "end": 2}, {"text": "DNA helicase", "start": 6, "end": 18}, {"text": "HPV E2 protein", "start": 42, "end": 56}]}}, "schema": []}
{"input": "Here we describe a mutant alpha subunit designed to inhibit receptor-mediated hormonal activation of Gs, the stimulatory regulator of adenylyl cyclase.", "output": {"entities": {"gene": [{"text": "Gs", "start": 101, "end": 103}, {"text": "adenylyl cyclase", "start": 134, "end": 150}]}}, "schema": []}
{"input": "A gapped search with the C-terminal region of CDED/LIOR revealed a 36-41% similarity to several proteins related to signal transduction and cell replication, such as ORC1 and KSR.", "output": {"entities": {"gene": [{"text": "CDED", "start": 46, "end": 50}, {"text": "LIOR", "start": 51, "end": 55}, {"text": "ORC1", "start": 166, "end": 170}, {"text": "KSR", "start": 175, "end": 178}]}}, "schema": []}
{"input": "Northern blot analysis demonstrated the ubiquitous expression of 2. 9 kb and 3.", "output": {"entities": {}}, "schema": []}
{"input": "Additionally, a variety of regulatory schemes contribute temporal and/or spatial restriction to TGF-beta responses.", "output": {"entities": {"gene": [{"text": "TGF-beta", "start": 96, "end": 104}]}}, "schema": []}
{"input": "A comparison of the clinical profile of cavernous malformations with and without associated venous malformations.", "output": {"entities": {}}, "schema": []}
{"input": "Magnetically induced optical self-pulsing in a nonlinear resonator.", "output": {"entities": {}}, "schema": []}
{"input": "Wave cybernetics: A simple model of wave-controlled nonlinear and nonlocal cooperative phenomena.", "output": {"entities": {}}, "schema": []}
{"input": "Autoionization rates and energy levels of triplet nf, v = 1 Rydberg states of H2.", "output": {"entities": {}}, "schema": []}
{"input": "Unitary-group approach to spin-dependent operators.", "output": {"entities": {}}, "schema": []}
{"input": "Nonlocal approach to scattering in a one-dimensional problem.", "output": {"entities": {}}, "schema": []}
{"input": "Soft-x-ray lasing at 32. 6 nm in Ne-like Ti ions driven by 40 J of energy from two 650-ps laser pulses.", "output": {"entities": {}}, "schema": []}
{"input": "Next, to identify regions of the promoter involved, we examined a series of tenascin-C promoter constructs with 5' deletions and showed that denatured collagen-dependent promoter activity was retained by a 122-base pair element, located-43 to-165 bp upstream of the RNA start site.", "output": {"entities": {"gene": [{"text": "tenascin-C promoter constructs", "start": 76, "end": 106}, {"text": "collagen-dependent promoter", "start": 151, "end": 178}]}}, "schema": []}
{"input": "Nuclear factor kappa B (NF-kappaB) is an important transcription factor for the genes of many pro-inflammatory proteins and is strongly activated by the cytokines interleukin-1 and tumor necrosis factor (TNF) alpha under various pathological conditions.", "output": {"entities": {"gene": [{"text": "Nuclear factor kappa B", "start": 0, "end": 22}, {"text": "NF-kappaB", "start": 24, "end": 33}, {"text": "interleukin-1", "start": 163, "end": 176}, {"text": "tumor necrosis factor (TNF) alpha", "start": 181, "end": 214}]}}, "schema": []}
{"input": "Unilateral naris occlusion and the rat accessory olfactory bulb.", "output": {"entities": {}}, "schema": []}
{"input": "The promoter of the rat pgp2/mdr1b gene has a GC-rich region (pgp2GC) that is highly conserved in mdr genes and contains an consensus Sp1 site.", "output": {"entities": {"gene": [{"text": "pgp2", "start": 24, "end": 28}, {"text": "mdr1b", "start": 29, "end": 34}, {"text": "pgp2GC", "start": 62, "end": 68}, {"text": "mdr genes", "start": 98, "end": 107}, {"text": "Sp1 site", "start": 134, "end": 142}]}}, "schema": []}
{"input": "Sp1' s role in transactivation of the pgp2/mdr1b promoter was tested in Drosophila Schneider cells.", "output": {"entities": {"gene": [{"text": "Sp1", "start": 0, "end": 3}, {"text": "pgp2", "start": 38, "end": 42}, {"text": "mdr1b", "start": 43, "end": 48}]}}, "schema": []}
{"input": "Measurements included bone mineral density of the lumbar spine and proximal femur (by dual-energy X-ray absorptiometry) and biochemical markers of bone remodeling (serum bone-specific alkaline phosphatase by immunoassay and urine deoxypyridinoline by high-pressure liquid chromatography).", "output": {"entities": {"gene": [{"text": "alkaline phosphatase", "start": 184, "end": 204}]}}, "schema": []}
{"input": "Human MGP is a 10-kD skeletal extracellular matrix (ECM) protein that consists of an 84-aa mature protein and a 19-aa transmembrane signal peptide.", "output": {"entities": {"gene": [{"text": "Human MGP", "start": 0, "end": 9}, {"text": "10-kD skeletal extracellular matrix (ECM) protein", "start": 15, "end": 64}]}}, "schema": []}
{"input": "Dual roles of p82, the clam CPEB homolog, in cytoplasmic polyadenylation and translational masking.", "output": {"entities": {"gene": [{"text": "p82", "start": 14, "end": 17}, {"text": "CPEB homolog", "start": 28, "end": 40}]}}, "schema": []}
{"input": "The pattern of RNase E digestion of finP305 RNA differed from FinP, and GST-FinO did not protect finP305 RNA from cleavage in vitro.", "output": {"entities": {"gene": [{"text": "RNase E", "start": 15, "end": 22}, {"text": "finP305 RNA", "start": 36, "end": 47}, {"text": "FinP", "start": 62, "end": 66}, {"text": "GST", "start": 72, "end": 75}, {"text": "FinO", "start": 76, "end": 80}, {"text": "finP305 RNA", "start": 97, "end": 108}]}}, "schema": []}
{"input": "Transcription readthrough into the inverted repeats has little effect on this event.", "output": {"entities": {}}, "schema": []}
{"input": "In the second case, an epidermal cyst was diagnosed.", "output": {"entities": {}}, "schema": []}
{"input": "MotA also binds a DNA sequence (a MotA box), centered at position-30.", "output": {"entities": {"gene": [{"text": "MotA", "start": 0, "end": 4}, {"text": "MotA box", "start": 34, "end": 42}]}}, "schema": []}
{"input": "We suggest that MotA and AsiA may function like certain eukaryotic TAFs (TATA binding protein (TBP) associated factors) whose binding to TBP results in transcription from new core promoter sequences.", "output": {"entities": {"gene": [{"text": "MotA", "start": 16, "end": 20}, {"text": "AsiA", "start": 25, "end": 29}, {"text": "eukaryotic TAFs", "start": 56, "end": 71}, {"text": "TATA binding protein (TBP) associated factors", "start": 73, "end": 118}, {"text": "TBP", "start": 137, "end": 140}]}}, "schema": []}
{"input": "The S229A variant can better flip modified bases but does not tightly lock the flipped base into the adenine-binding pocket, suggesting that Ser229 could form a contact to the flipped adenine.", "output": {"entities": {}}, "schema": []}
{"input": "The high conservation of the 3' terminus suggests that this region directs the assembly of proteins required for the initiation of RNA replication.", "output": {"entities": {}}, "schema": []}
{"input": "All stimulations were down-regulated with GnRH-a commenced on day 21 in a long protocol before gonadotropin stimulation.", "output": {"entities": {"gene": [{"text": "GnRH-a", "start": 42, "end": 48}, {"text": "gonadotropin", "start": 95, "end": 107}]}}, "schema": []}
{"input": "The sequence up to-267 bp relative to the transcription start site was sufficient to enhance reporter gene expression depending on the mesodermal differentiation of P19 cells.", "output": {"entities": {}}, "schema": []}
{"input": "No significant differences between the substituted and wild type peptides were observed, suggesting that this substitution in the intact protein may cause disruption of global rather than local structures.", "output": {"entities": {}}, "schema": []}
{"input": "C3 toxin completely inhibited RhoA function, partially inhibited SRE: Luc activity, but had no effect on LPA-stimulated c-Fos expression.", "output": {"entities": {"gene": [{"text": "C3 toxin", "start": 0, "end": 8}, {"text": "RhoA", "start": 30, "end": 34}, {"text": "Luc", "start": 70, "end": 73}, {"text": "c-Fos", "start": 120, "end": 125}]}}, "schema": []}
{"input": "However, C3 toxin alone or in combination with growth factors did not stimulate AP-1: Luc activity and actually antagonized the synergistic activation of AP-1: Luc observed in response to co-stimulation with growth factors and Ro-31-8220.", "output": {"entities": {"gene": [{"text": "C3 toxin", "start": 9, "end": 17}, {"text": "AP-1", "start": 80, "end": 84}, {"text": "Luc", "start": 86, "end": 89}, {"text": "AP-1", "start": 154, "end": 158}, {"text": "Luc", "start": 160, "end": 163}]}}, "schema": []}
{"input": "The aim of the present study was to examine the antimicrobial susceptibility to 10 currently used antimicrobial agents of 50 strains of P. acnes isolated from acne lesions and identified using a Rap ID ANA II panel.", "output": {"entities": {}}, "schema": []}
{"input": "The role of intraoperative echocardiography in surgery of the heart and large vessels", "output": {"entities": {}}, "schema": []}
{"input": "Taken together, our results demonstrate that CAP1 is involved in multidrug resistance and oxidative stress response in C. albicans.", "output": {"entities": {"gene": [{"text": "CAP1", "start": 45, "end": 49}]}}, "schema": []}
{"input": "Trinipatch is a small, transparent, matricial, monolayer patch with an absorption promoter, marketed in two dose-strengths (5 mg/24 h and 10 mg/24 h) by Laboratoires Synthelabo.", "output": {"entities": {}}, "schema": []}
{"input": "The RMRI was tested for interrater reliability using three simulated and 10 actual patients.", "output": {"entities": {}}, "schema": []}
{"input": "The starting point is the consideration that the conceptions underlying the ICIDH are not suitable to serve as a mainstay of a model for diagnostics in rehabilitation because they do not reflect essential characteristics of the diagnostic process which is the basis for intervention.", "output": {"entities": {}}, "schema": []}
{"input": "OBJECTIVE: This meta-analysis of 67 controlled trials was performed to quantify the cholesterol-lowering effect of major dietary fibers.", "output": {"entities": {}}, "schema": []}
{"input": "When the high affinity hnRNP A1 binding site was inserted into the beta-globin reporter, Rev was able to increase the cytoplasmic levels of unspliced mRNAs to 14%.", "output": {"entities": {"gene": [{"text": "hnRNP A1 binding site", "start": 23, "end": 44}, {"text": "beta-globin reporter", "start": 67, "end": 87}, {"text": "Rev", "start": 89, "end": 92}]}}, "schema": []}
{"input": "To date, two such proteins, PLZF and LAZ-3/BCL-6, have been implicated in oncogenesis.", "output": {"entities": {"gene": [{"text": "PLZF", "start": 28, "end": 32}, {"text": "LAZ-3", "start": 37, "end": 42}, {"text": "BCL-6", "start": 43, "end": 48}]}}, "schema": []}
{"input": "Overexpression of POG1 inhibits alpha-factor-induced G1 arrest and transcriptional repression of the CLN1 and CLN2 genes.", "output": {"entities": {"gene": [{"text": "POG1", "start": 18, "end": 22}, {"text": "alpha-factor", "start": 32, "end": 44}, {"text": "CLN1", "start": 101, "end": 105}, {"text": "CLN2 genes", "start": 110, "end": 120}]}}, "schema": []}
{"input": "We now show that RNU2 fragility can be induced by transfection with an expression vector encoding Ad12 E1B 55 kDa alone but not by an E1 vector encoding all E1 products (3 E1A proteins, as well as the E1B 19 kDa and 55 kDa proteins).", "output": {"entities": {"gene": [{"text": "RNU2", "start": 17, "end": 21}, {"text": "Ad12 E1B", "start": 98, "end": 106}, {"text": "E1", "start": 134, "end": 136}, {"text": "E1 products", "start": 157, "end": 168}, {"text": "E1A proteins", "start": 172, "end": 184}, {"text": "E1B", "start": 201, "end": 204}]}}, "schema": []}
{"input": "Competitionsupershift EMSA assays revealed that multiple proteins were involved in bandshift complex formation with KCS, one of which was identified as factor Sp1.", "output": {"entities": {"gene": [{"text": "KCS", "start": 116, "end": 119}]}}, "schema": []}
{"input": "Similarity of DNA binding and transcriptional regulation by Caenorhabditis elegans MAB-3 and Drosophila melanogaster DSX suggests conservation of sex determining mechanisms.", "output": {"entities": {"gene": [{"text": "Caenorhabditis elegans MAB-3", "start": 60, "end": 88}, {"text": "Drosophila melanogaster DSX", "start": 93, "end": 120}]}}, "schema": []}
{"input": "Neither the p42/44 nor the JNK pathway was involved in the action of IL-1beta.", "output": {"entities": {"gene": [{"text": "p42/44", "start": 12, "end": 18}, {"text": "JNK", "start": 27, "end": 30}, {"text": "IL-1beta", "start": 69, "end": 77}]}}, "schema": []}
{"input": "In protocol 2, eight different subjects performed Con and Ecc arm curls to fatigue, followed by postexercise muscle ischemia, by using the same resistance as in protocol 1.", "output": {"entities": {}}, "schema": []}
{"input": "Airflow was measured with a custom-designed turbine and a 45-ft.-long cable to reach the volume-measuring module.", "output": {"entities": {}}, "schema": []}
{"input": "Both mutations confer amino acid substitutions in the viral coat protein but differ in their relative abilities to utilize the foreign scaffolding protein.", "output": {"entities": {"gene": [{"text": "viral coat protein", "start": 54, "end": 72}, {"text": "scaffolding protein", "start": 135, "end": 154}]}}, "schema": []}
{"input": "Complete recovery of liver function after this surgery tended to be slow.", "output": {"entities": {}}, "schema": []}
{"input": "Although both transcripts share the first nine exons, exon 10 of ZIS-2 is lacking in ZIS-1, and instead, exon 11 (10th exon) of ZIS-1 is larger in size, leading to the longer 3'-UTR.", "output": {"entities": {"gene": [{"text": "ZIS-2", "start": 65, "end": 70}, {"text": "ZIS-1", "start": 85, "end": 90}, {"text": "ZIS-1", "start": 128, "end": 133}]}}, "schema": []}
{"input": "IFN-gamma was elevated during active TB when compared with healthy controls, declining during and after treatment.", "output": {"entities": {"gene": [{"text": "IFN-gamma", "start": 0, "end": 9}]}}, "schema": []}
{"input": "The missing 5' sequences were obtained by 5'-rapid amplification of cDNA ends and by analysis of an NHE5 genomic clone, and the missing 3' sequences were obtained by 3'-rapid amplification of cDNA ends.", "output": {"entities": {"gene": [{"text": "NHE5 genomic clone", "start": 100, "end": 118}]}}, "schema": []}
{"input": "If no alloantibodies are detected, further analysis to define a role of drug-related or autoantibodies is required.", "output": {"entities": {}}, "schema": []}
{"input": "This dependence, however, can be overcome to a large extent by dividing min LVdP/dt by mean aortic pressure.", "output": {"entities": {}}, "schema": []}
{"input": "Genoa, Italy, 24-28 August 1997.", "output": {"entities": {}}, "schema": []}
{"input": "Electronic structure of delta-plutonium and of single Al, Ga, and Sc impurities in delta-plutonium.", "output": {"entities": {}}, "schema": []}
{"input": "Bound-exciton transfer and photoluminescence undulation spectra for acceptors in ZnTe.", "output": {"entities": {}}, "schema": []}
{"input": "Unified theory of segregated-stack organic charge-transfer solids: Magnetic properties.", "output": {"entities": {}}, "schema": []}
{"input": "II.", "output": {"entities": {}}, "schema": []}
{"input": "Envelope-function matching conditions for GaAs/(Al, Ga) As heterojunctions.", "output": {"entities": {}}, "schema": []}
{"input": "Neutron scattering measurements of critical exponents in CsMnBr3: A Z2 & gt; = 1 antiferromagnet.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, in normal intestinal epithelial goblet cells, TbetaRI and TbetaRII can respond to autocrine but not exogenous TGF-beta without the participation of TbetaRIII.", "output": {"entities": {"gene": [{"text": "TbetaRI", "start": 52, "end": 59}, {"text": "TbetaRII", "start": 64, "end": 72}, {"text": "TGF-beta", "start": 116, "end": 124}, {"text": "TbetaRIII", "start": 154, "end": 163}]}}, "schema": []}
{"input": "The history of exposure and carboxyhemoglobin levels should alert the physician to this diagnosis.", "output": {"entities": {"gene": [{"text": "carboxyhemoglobin", "start": 28, "end": 45}]}}, "schema": []}
{"input": "The odds ratio for CHD was 1. 21 (95% confidence interval, 0. 84-1. 75) given a positive serostatus of specific IgG antibodies after adjustment for covariates.", "output": {"entities": {"gene": [{"text": "IgG", "start": 112, "end": 115}]}}, "schema": []}
{"input": "Another group of HIPP-and HCX-lesioned animals trained on the tasks after the lesion showed reduced impairments of the type described above, suggesting that extrahippocampal structures trained after the lesion can assume the role of the hippocampus to some degree.", "output": {"entities": {}}, "schema": []}
{"input": "The case for neutrinos from SN 1987A.", "output": {"entities": {}}, "schema": []}
{"input": "Scaling of fluctuations in one-dimensional interface and hopping models.", "output": {"entities": {}}, "schema": []}
{"input": "Model of spatiotemporal dynamics of stick-slip motion.", "output": {"entities": {}}, "schema": []}
{"input": "NMR of diffusing atoms in a periodic porous medium in the presence of a nonuniform magnetic field.", "output": {"entities": {}}, "schema": []}
{"input": "Microstructure and conductivity of hierarchical laminate composites.", "output": {"entities": {}}, "schema": []}
{"input": "Anisotropic heat transport in the octylcyanobiphenyl (8CB) liquid crystal.", "output": {"entities": {}}, "schema": []}
{"input": "Direct approach to the study of soliton perturbations.", "output": {"entities": {}}, "schema": []}
{"input": "Mutations affecting only CD4 regulation mapped to residues previously shown to mediate the binding of Nef to this receptor, such as W57 and L58, as well as to an AP-recruiting dileucine motif and to an acidic dipeptide in the C-terminal region of the protein.", "output": {"entities": {"gene": [{"text": "CD4", "start": 25, "end": 28}, {"text": "Nef", "start": 102, "end": 105}, {"text": "AP-recruiting dileucine motif", "start": 162, "end": 191}]}}, "schema": []}
{"input": "The lytic cycle of KSHV, probably under the initial control of the KSHV/Rta gene, may directly contribute to tumor pathogenesis.", "output": {"entities": {"gene": [{"text": "KSHV/Rta gene", "start": 67, "end": 80}]}}, "schema": []}
{"input": "We conclude that (i) we have identified several candidate latency genes of murine gammaHV68, (ii) expression of genes during latency may be different in different organs, consistent with multiple latency programs and/or multiple cellular sites of latency, and (iii) regions of the viral genome (v-bcl-2 gene, v-GCR gene, and gene 73) are transcribed during latency with both gammaHV68 and primate gammaherpesviruses.", "output": {"entities": {"gene": [{"text": "v-bcl-2 gene", "start": 295, "end": 307}, {"text": "v-GCR gene", "start": 309, "end": 319}, {"text": "gene 73", "start": 325, "end": 332}]}}, "schema": []}
{"input": "These data indicate a functional role for U1 in NRS-mediated splicing inhibition.", "output": {"entities": {"gene": [{"text": "U1", "start": 42, "end": 44}, {"text": "NRS", "start": 48, "end": 51}]}}, "schema": []}
{"input": "This suggests that the DcuS-DcuR system responds to external substrates.", "output": {"entities": {"gene": [{"text": "DcuS", "start": 23, "end": 27}, {"text": "DcuR", "start": 28, "end": 32}]}}, "schema": []}
{"input": "Crossover in the specific heat of dilute magnets induced by critical spin-wave dynamics.", "output": {"entities": {}}, "schema": []}
{"input": "Erratum: Absence of precursor effects above the martensitic transformation in a virgin crystal of Li metal", "output": {"entities": {}}, "schema": []}
{"input": "Interplane coupling in the superconductor Y2Ba4Cu7O15 as revealed by NQR spin-echo double resonance.", "output": {"entities": {}}, "schema": []}
{"input": "Electronic structure of a buried NiSi2 or CoSi2 layer in bulk Si.", "output": {"entities": {}}, "schema": []}
{"input": "Raman investigation of YBa2-xLaxCu3O7 ceramics.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of point defects on lattice parameters of semiconductors.", "output": {"entities": {}}, "schema": []}
{"input": "Chaotic electron dynamics around a single elliptically shaped antidot.", "output": {"entities": {}}, "schema": []}
{"input": "However, deletions of the C terminal 11 or 14 amino acids had more substantial effects.", "output": {"entities": {}}, "schema": []}
{"input": "Sixty months after the initial vaccination, all vaccinees who received annual follow-up still had protective levels of anti-HAV.", "output": {"entities": {"gene": [{"text": "anti-HAV", "start": 119, "end": 127}]}}, "schema": []}
{"input": "However, after PRK at 5 weeks of age, partial retreatment may be necessary due to regression of the PRK effect.", "output": {"entities": {}}, "schema": []}
{"input": "Its early lesions were characterized by angiomatosis, vasculopathy, and proliferation of synoviocytes and fibroblasts.", "output": {"entities": {}}, "schema": []}
{"input": "Molecular cloning of human cDNA encoding a novel beta1, 6-N-acetylglucosaminyltransferase forming core 2 and core 4.", "output": {"entities": {"gene": [{"text": "beta1, 6-N-acetylglucosaminyltransferase", "start": 49, "end": 89}]}}, "schema": []}
{"input": "Interspecific mouse back-cross analysis identified the loci for mouse 3Ost genes and syntenic assignments of corresponding human isologs were confirmed by the identification of mapped sequence-tagged site markers.", "output": {"entities": {"gene": [{"text": "mouse 3Ost genes", "start": 64, "end": 80}]}}, "schema": []}
{"input": "The Scales of Cognitive Impairment Rated From Institutional Records (SCIRFIR), a battery based on commonly used dementia rating instruments, was tested on the records of 26 chronically institutionalized, elderly schizophrenia patients, for the purpose of retrospectively evaluating the long-term course of cognitive change in schizophrenia and relating it to available autopsy materials.", "output": {"entities": {}}, "schema": []}
{"input": "Most recently, the use of the product of brain weight and clearance has been proposed.", "output": {"entities": {}}, "schema": []}
{"input": "Recombination and transcription of the endogenous Ig heavy chain locus is effected by the Ig heavy chain intronic enhancer core region in the absence of the matrix attachment regions.", "output": {"entities": {"gene": [{"text": "endogenous Ig heavy chain locus", "start": 39, "end": 70}, {"text": "Ig heavy chain intronic enhancer core region", "start": 90, "end": 134}]}}, "schema": []}
{"input": "Two of these motifs are part of a highly conserved and inducible dyad symmetry element shown previously to control a remote IL-2 enhancer and the CD18 promoter.", "output": {"entities": {"gene": [{"text": "IL-2 enhancer", "start": 124, "end": 137}, {"text": "CD18 promoter", "start": 146, "end": 159}]}}, "schema": []}
{"input": "In concert with the coactivator CREB binding protein/p300, which interacts with GABPalpha, the binding of GABPalpha and-beta to the dyad symmetry element controls the induction of IL-16 promoter in T cells.", "output": {"entities": {"gene": [{"text": "CREB binding protein", "start": 32, "end": 52}, {"text": "p300", "start": 53, "end": 57}, {"text": "GABPalpha", "start": 80, "end": 89}, {"text": "GABPalpha and-beta", "start": 106, "end": 124}, {"text": "IL-16 promoter", "start": 180, "end": 194}]}}, "schema": []}
{"input": "TPO by itself did not activate ERK1, ERK2 and protein kinase C (PKC), whereas TPO directly enhanced the PKC-dependent activation of ERKs induced by other agonists including thrombin and phorbol esters, without affecting the PKC activation by those agonists.", "output": {"entities": {"gene": [{"text": "TPO", "start": 0, "end": 3}, {"text": "ERK1", "start": 31, "end": 35}, {"text": "ERK2", "start": 37, "end": 41}, {"text": "protein kinase C", "start": 46, "end": 62}, {"text": "PKC", "start": 64, "end": 67}, {"text": "TPO", "start": 78, "end": 81}, {"text": "PKC", "start": 104, "end": 107}, {"text": "ERKs", "start": 132, "end": 136}, {"text": "thrombin", "start": 173, "end": 181}, {"text": "PKC", "start": 224, "end": 227}]}}, "schema": []}
{"input": "BACKGROUND: In the ubiquitin-dependent proteolysis pathway, a ubiquitin ligase (E3) is responsible for substrate selectivity and timing of degradation.", "output": {"entities": {"gene": [{"text": "ubiquitin", "start": 19, "end": 28}, {"text": "ubiquitin ligase", "start": 62, "end": 78}, {"text": "E3", "start": 80, "end": 82}]}}, "schema": []}
{"input": "CONCLUSIONS: Fission yeast SCF is composed of Pop1 and Pop2, two structurally related but functionally independent F-box/WD-repeat proteins.", "output": {"entities": {"gene": [{"text": "Fission yeast SCF", "start": 13, "end": 30}, {"text": "Pop1", "start": 46, "end": 50}, {"text": "Pop2", "start": 55, "end": 59}, {"text": "F-box/WD-repeat proteins", "start": 115, "end": 139}]}}, "schema": []}
{"input": "19F NMR studies in ABF4-type layered antiferromagnets.", "output": {"entities": {}}, "schema": []}
{"input": "Optical-absorption spectra, crystal-field energy levels, and transition line strengths of holmium in trigonal Na3", "output": {"entities": {}}, "schema": []}
{"input": "Observation of dipolar interactions between Pb0 defects at the (111) Si/SiO2 interface.", "output": {"entities": {}}, "schema": []}
{"input": "Quantum-statistical theory of high-field transport phenomena.", "output": {"entities": {}}, "schema": []}
{"input": "NH3 and NO interaction with Si (100)-(2 x 1) surfaces.", "output": {"entities": {}}, "schema": []}
{"input": "Far-infrared hopping conductivity in the CuO chains of a single-domain YBa2Cu3O7-delta crystal.", "output": {"entities": {}}, "schema": []}
{"input": "Surface spin waves in a Heisenberg ferrimagnet with a single-ion anisotropy (uniaxial and nonuniaxial).", "output": {"entities": {}}, "schema": []}
{"input": "Multilayer-relaxation geometry and electronic structure of a W (111) surface.", "output": {"entities": {}}, "schema": []}
{"input": "Temperature dependence of the sublattice spontaneous magnetization of YBa2Cu3O6.", "output": {"entities": {}}, "schema": []}
{"input": "GW Gamma approximation for electron self-energies in semiconductors and insulators.", "output": {"entities": {}}, "schema": []}
{"input": "Precision measurement of the pion mass difference m pi--m pi 0.", "output": {"entities": {}}, "schema": []}
{"input": "Testing gravity to second post-Newtonian order: A field-theory approach.", "output": {"entities": {}}, "schema": []}
{"input": "Genetic experiments using mutants defective in apontic and bruno reveal a functional interaction between these genes.", "output": {"entities": {"gene": [{"text": "apontic", "start": 47, "end": 54}, {"text": "bruno", "start": 59, "end": 64}]}}, "schema": []}
{"input": "In the current model, Wingless/Wnt signal stabilizes Armadillo/beta-catenin, which then accumulates in nuclei and binds TCF/LEF family proteins, forming bipartite transcription factors which activate transcription of Wingless/Wnt responsive genes.", "output": {"entities": {"gene": [{"text": "Wingless", "start": 22, "end": 30}, {"text": "Wnt", "start": 31, "end": 34}, {"text": "Armadillo", "start": 53, "end": 62}, {"text": "beta-catenin", "start": 63, "end": 75}, {"text": "TCF", "start": 120, "end": 123}, {"text": "LEF", "start": 124, "end": 127}, {"text": "Wingless", "start": 217, "end": 225}, {"text": "Wnt", "start": 226, "end": 229}]}}, "schema": []}
{"input": "In support of clinical antianginal studies, the vasodilator nicorandil (NIC) was combined with the beta-adrenergic receptor antagonists propranolol (PRO) and atenolol (ATN) and with the calcium channel blocker diltiazem (DTZ) to determine their cardiovascular and pharmacokinetic interactions.", "output": {"entities": {"gene": [{"text": "beta-adrenergic receptor", "start": 99, "end": 123}]}}, "schema": []}
{"input": "Elimination of ETH1 in apn1 strains also increased spontaneous mutation rates 9-or 31-fold compared to the wild type as determined by reversion to adenine or lysine prototrophy, respectively.", "output": {"entities": {"gene": [{"text": "ETH1", "start": 15, "end": 19}, {"text": "apn1", "start": 23, "end": 27}]}}, "schema": []}
{"input": "Elimination of ETH1 in apn1 strains also increased spontaneous mutation rates 9-or 31-fold compared to the wild type as determined by reversion to adenine or lysine prototrophy, respectively.", "output": {"entities": {"gene": [{"text": "ETH1", "start": 15, "end": 19}, {"text": "apn1", "start": 23, "end": 27}]}}, "schema": []}
{"input": "Mammalian Ras GTPase-activating protein (GAP), p120 Ras-GAP, has been implicated as both a downregulator and effector of Ras proteins, but its precise role in Ras-mediated signal transduction pathways is unclear.", "output": {"entities": {"gene": [{"text": "Ras GTPase-activating protein", "start": 10, "end": 39}, {"text": "GAP", "start": 41, "end": 44}, {"text": "p120 Ras", "start": 47, "end": 55}, {"text": "GAP", "start": 56, "end": 59}, {"text": "Ras proteins", "start": 121, "end": 133}, {"text": "Ras", "start": 159, "end": 162}]}}, "schema": []}
{"input": "Three mog-1 alleles possess premature stop codons and are likely to be null alleles, and one is a missense mutation and is likely to retain residual activity. mog-1 mRNA is expressed in both germ line and somatic tissues and appears to be ubiquitous.", "output": {"entities": {"gene": [{"text": "mog-1 alleles", "start": 6, "end": 19}, {"text": "mog-1 mRNA", "start": 159, "end": 169}]}}, "schema": []}
{"input": "However, unlike the SIN3 gene of Saccharomyces cerevisiae, pst1 (+) is essential for cell viability.", "output": {"entities": {"gene": [{"text": "SIN3 gene", "start": 20, "end": 29}, {"text": "pst1 (+)", "start": 59, "end": 67}]}}, "schema": []}
{"input": "The Nmd3 protein sequence does not contain readily recognizable motifs of known function.", "output": {"entities": {"gene": [{"text": "Nmd3 protein sequence", "start": 4, "end": 25}]}}, "schema": []}
{"input": "The distribution of the various repeats suggests its organization is similar to the beta-heterochromatic regions near the base of the major chromosome arms.", "output": {"entities": {}}, "schema": []}
{"input": "Calcitonin simultaneously regulates both periosteal hyperostosis and trabecular osteopenia in the spinal hyperostotic mouse (twy/twy) in vivo.", "output": {"entities": {"gene": [{"text": "Calcitonin", "start": 0, "end": 10}, {"text": "twy", "start": 125, "end": 128}, {"text": "twy", "start": 129, "end": 132}]}}, "schema": []}
{"input": "In addition, we also show that cdk7 may phosphorylate the carboxy-terminal domain (CTD) of RNA pol II in the absence of promoter opening.", "output": {"entities": {"gene": [{"text": "cdk7", "start": 31, "end": 35}, {"text": "RNA pol II", "start": 91, "end": 101}]}}, "schema": []}
{"input": "The therapy with a H2-receptor antagonist is less effective than the triple therapies with omeprazole or lansoprazole.", "output": {"entities": {"gene": [{"text": "H2-receptor", "start": 19, "end": 30}]}}, "schema": []}
{"input": "In humans, three tissue-specific plastin isoforms have been identified.", "output": {"entities": {"gene": [{"text": "tissue-specific plastin isoforms", "start": 17, "end": 49}]}}, "schema": []}
{"input": "No TATA or Inr sequence was found.", "output": {"entities": {}}, "schema": []}
{"input": "The inhibition by the RIalpha subunit is reversed by addition of nanomolar concentrations of cAMP (Ka = 40 nM), thus demonstrating that PrKX is a novel, type I cAMP-dependent protein kinase that is activated at lower cAMP concentrations than the holoenzyme with the Calpha subunit of cAMP-dependent protein kinase.", "output": {"entities": {"gene": [{"text": "RIalpha subunit", "start": 22, "end": 37}, {"text": "PrKX", "start": 136, "end": 140}, {"text": "type I cAMP-dependent protein kinase", "start": 153, "end": 189}, {"text": "Calpha subunit", "start": 266, "end": 280}, {"text": "cAMP-dependent protein kinase", "start": 284, "end": 313}]}}, "schema": []}
{"input": "In addition, in vitro mutagenesis of both Engrailed and Pbx1 sites indicated that other unidentified sites are responsible for the transcriptional enhancement observed with the intronic fragment.", "output": {"entities": {"gene": [{"text": "Engrailed", "start": 42, "end": 51}, {"text": "Pbx1 sites", "start": 56, "end": 66}]}}, "schema": []}
{"input": "Several secondary structure elements were identified.", "output": {"entities": {}}, "schema": []}
{"input": "Here, we evidence that the developmental functions of the family of transcription factors characterized by the POU DNA binding motif exerts roles in mammalian development.", "output": {"entities": {"gene": [{"text": "POU DNA binding motif", "start": 111, "end": 132}]}}, "schema": []}
{"input": "High-affinity site-specific DNA binding by POU domain transcription factors requires both the POU-specific and the POU-homeodomain.", "output": {"entities": {"gene": [{"text": "POU domain transcription factors", "start": 43, "end": 75}, {"text": "POU-specific", "start": 94, "end": 106}, {"text": "POU-homeodomain", "start": 115, "end": 130}]}}, "schema": []}
{"input": "In the Oct-1 crystal, the POU-specific domain recognizes a GCAT half-site, while the corresponding sequence recognized by the Pit-1 POU-specific domain, GTAT, is on the opposing strand.", "output": {"entities": {"gene": [{"text": "Oct-1", "start": 7, "end": 12}, {"text": "POU-specific domain", "start": 26, "end": 45}, {"text": "Pit-1 POU", "start": 126, "end": 135}]}}, "schema": []}
{"input": "Most other end points were highly significant, and death, which was monitored across the U. S. program, was different with p < 0. 0001.", "output": {"entities": {}}, "schema": []}
{"input": "The other is located at-1335, outside this highly conserved region.", "output": {"entities": {}}, "schema": []}
{"input": "Those radiological aspects were distributed in two categories: 1) type I-presenting variable sinusoidal filling.", "output": {"entities": {}}, "schema": []}
{"input": "Results demonstrated that the presence of myofibroblasts varied considerably from case to case and was always related to smooth muscle cell dispersion, which occurred around medium-sized damaged portal vein branches.", "output": {"entities": {}}, "schema": []}
{"input": "Radiative corrections to beta decay and the possibility of a fourth generation.", "output": {"entities": {}}, "schema": []}
{"input": "Depth-controlled grazing-incidence diffraction of synchrotron x radiation.", "output": {"entities": {}}, "schema": []}
{"input": "Oscillatory exchange of atoms between traps containing Bose condensates.", "output": {"entities": {}}, "schema": []}
{"input": "Structure determination of an adsorbate-induced multilayer reconstruction: (1 x 2)-H/Ni (110).", "output": {"entities": {}}, "schema": []}
{"input": "Magnetic trapping of spin-polarized atomic hydrogen.", "output": {"entities": {}}, "schema": []}
{"input": "Northern blot and in situ hybridization analyses revealed GPR34 mRNA transcripts in several human and rat brain regions.", "output": {"entities": {"gene": [{"text": "GPR34 mRNA transcripts", "start": 58, "end": 80}]}}, "schema": []}
{"input": "The microphthalmia-TFE (MiT) subfamily of basic helix-loop-helix leucine zipper (bHLH-ZIP) transcription factors, including TFE3, TFEB, TFEC, and Mitf, has been implicated in the regulation of tissue-specific gene expression in several cell lineages.", "output": {"entities": {"gene": [{"text": "microphthalmia-TFE", "start": 4, "end": 22}, {"text": "MiT", "start": 24, "end": 27}, {"text": "basic helix-loop-helix leucine zipper (bHLH-ZIP) transcription factors", "start": 42, "end": 112}, {"text": "TFE3", "start": 124, "end": 128}, {"text": "TFEB", "start": 130, "end": 134}, {"text": "TFEC", "start": 136, "end": 140}, {"text": "Mitf", "start": 146, "end": 150}]}}, "schema": []}
{"input": "Fifty-seven patients aged < 55 years with acute lymphoblastic leukemia (ALL) in second or third bone marrow (BM) relapse or refractory to first-line therapy were enrolled in an Italian cooperative study.", "output": {"entities": {}}, "schema": []}
{"input": "The dorsal nerves of the penis were anesthetized bilaterally with lidocaine.", "output": {"entities": {}}, "schema": []}
{"input": "Early-onset scleral necrosis after iodine I 125 plaque radiotherapy for ciliochoroidal melanoma.", "output": {"entities": {}}, "schema": []}
{"input": "Successful interaction of ARF and PKC-alpha with PLD1 was not achieved, but a C-terminal fragment of human PLD1 (denoted \" D4 \") interacted with the active mutant of RhoA, RhoAVal-14.", "output": {"entities": {"gene": [{"text": "ARF", "start": 26, "end": 29}, {"text": "PKC-alpha", "start": 34, "end": 43}, {"text": "PLD1", "start": 49, "end": 53}, {"text": "human PLD1", "start": 101, "end": 111}, {"text": "RhoA", "start": 166, "end": 170}, {"text": "RhoAVal-14", "start": 172, "end": 182}]}}, "schema": []}
{"input": "Vacuum Rabi splitting as a feature of linear-dispersion theory: Analysis and experimental observations.", "output": {"entities": {}}, "schema": []}
{"input": "High-pressure effects on ultrafast-relaxation kinetics of excitons in polydiacetylene 4BCMU.", "output": {"entities": {}}, "schema": []}
{"input": "Drag reduction in turbulent flows by polymers.", "output": {"entities": {}}, "schema": []}
{"input": "Large scale electronic structure calculations.", "output": {"entities": {}}, "schema": []}
{"input": "Current world literature.", "output": {"entities": {}}, "schema": []}
{"input": "These results show that Ski is a component of the HDAC complex and that Ski is required for the transcriptional repression mediated by this complex.", "output": {"entities": {"gene": [{"text": "Ski", "start": 24, "end": 27}, {"text": "HDAC complex", "start": 50, "end": 62}, {"text": "Ski", "start": 72, "end": 75}]}}, "schema": []}
{"input": "Recombinant unr acts synergistically with recombinant PTB to stimulate translation dependent on the rhinovirus IRES.", "output": {"entities": {"gene": [{"text": "unr", "start": 12, "end": 15}, {"text": "PTB", "start": 54, "end": 57}]}}, "schema": []}
{"input": "Analysis of the consensus binding sequence and the DNA-binding domain of ZF5.", "output": {"entities": {"gene": [{"text": "ZF5", "start": 73, "end": 76}]}}, "schema": []}
{"input": "Mapping of the human Voltage-Dependent Anion Channel isoforms 1 and 2 reconsidered.", "output": {"entities": {"gene": [{"text": "human Voltage-Dependent Anion Channel isoforms 1 and 2", "start": 15, "end": 69}]}}, "schema": []}
{"input": "Identification of RNase T as a high-copy suppressor of the UV sensitivity associated with single-strand DNA exonuclease deficiency in Escherichia coli.", "output": {"entities": {"gene": [{"text": "RNase T", "start": 18, "end": 25}, {"text": "single-strand DNA exonuclease", "start": 90, "end": 119}]}}, "schema": []}
{"input": "Inhibition of phosphatidylinositol-3 kinase did not have a significant effect on p53 conformation but did have a weak but significant effect on Tpo-enhanced viability.", "output": {"entities": {"gene": [{"text": "phosphatidylinositol-3 kinase", "start": 14, "end": 43}, {"text": "p53", "start": 81, "end": 84}, {"text": "Tpo", "start": 144, "end": 147}]}}, "schema": []}
{"input": "No difference in percentage of males in semen production was noted between strains, CP levels, or feeding regimens.", "output": {"entities": {}}, "schema": []}
{"input": "Further analysis of AP-1 DNA binding activities in 7-to 14-day culture activated HSCs led to the discovery of high mobility AP-1 complexes (HMAP-1).", "output": {"entities": {"gene": [{"text": "AP-1", "start": 20, "end": 24}, {"text": "high mobility AP-1 complexes", "start": 110, "end": 138}, {"text": "HMAP-1", "start": 140, "end": 146}]}}, "schema": []}
{"input": "Mutations of the AP-1 site of the TIMP-1 promoter that prevented formation of HMAP-1 caused a 70% loss of activity in transfected activated HSCs.", "output": {"entities": {"gene": [{"text": "AP-1 site", "start": 17, "end": 26}, {"text": "TIMP-1 promoter", "start": 34, "end": 49}, {"text": "HMAP-1", "start": 78, "end": 84}]}}, "schema": []}
{"input": "STUDY DESIGN: Salivary immunoglobulin A levels of each of 20 subjects were determined on 3 occasions: first, while the subject was still smoking; second, 7 days after cessation of smoking; third, on the 14th day after cessation.", "output": {"entities": {"gene": [{"text": "Salivary immunoglobulin A", "start": 14, "end": 39}]}}, "schema": []}
{"input": "Role of g2 in relating the Schwinger and Gerasimov-Drell-Hearn sum rules.", "output": {"entities": {}}, "schema": []}
{"input": "Spectroscopy of negative ions utilizing multiphoton detachment in a Raman coupling regime.", "output": {"entities": {}}, "schema": []}
{"input": "Band structure effects of transport properties in icosahedral quasicrystals.", "output": {"entities": {}}, "schema": []}
{"input": "Acoustic transmission spectra in the Penrose lattice.", "output": {"entities": {}}, "schema": []}
{"input": "Two-Channel Kondo Lattice: An Incoherent Metal.", "output": {"entities": {}}, "schema": []}
{"input": "Basal midexpiratory lower esophageal sphincter pressure was similar in the study group (mean [SD] 20. 1 [9. 1] mmHg) and controls (17. 6 [6. 0] mmHg); the pressure did not change following EVS or EVL.", "output": {"entities": {}}, "schema": []}
{"input": "On the other hand, subjects with air trapping (residual volume (RV)/total lung capacity (TLC) > 37%) disclosed not only a higher n (mit) (0. 63 +/-0. 17 versus 0. 43 +/-0. 07 mt x microm (-2), p < 0. 05) but shorter sarcomeres (L (sar)) than subjects without this functional abnormality (2. 08 +/-0. 16 to 2. 27 +/-0. 15 microm, p < 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "Cyclin D1-associated kinase activity and protein levels were increased in mammary tumors from murine mammary tumor virus-pp60 (c-src527F) transgenic mice.", "output": {"entities": {"gene": [{"text": "Cyclin D1-associated kinase", "start": 0, "end": 27}, {"text": "pp60", "start": 121, "end": 125}, {"text": "c-src527F", "start": 127, "end": 136}]}}, "schema": []}
{"input": "The SH2 domain-containing inositol 5'-phosphatase (SHIP) recruits the p85 subunit of phosphoinositide 3-kinase during FcgammaRIIb1-mediated inhibition of B cell receptor signaling.", "output": {"entities": {"gene": [{"text": "SH2 domain-containing inositol 5'-phosphatase", "start": 4, "end": 49}, {"text": "SHIP", "start": 51, "end": 55}, {"text": "p85 subunit", "start": 70, "end": 81}, {"text": "phosphoinositide 3-kinase", "start": 85, "end": 110}, {"text": "FcgammaRIIb1", "start": 118, "end": 130}, {"text": "B cell receptor", "start": 154, "end": 169}]}}, "schema": []}
{"input": "An increase in bone mineral density at the spine, total hip, and total body has been reported with raloxifene but seems to be less than that seen with estrogen or alendronate therapy.", "output": {"entities": {}}, "schema": []}
{"input": "However, in those studies due to the presence of thiol agents in the PKC preparations, the sensitive reaction of BPO with redox-active cysteine residues in PKC was not observed.", "output": {"entities": {"gene": [{"text": "PKC", "start": 69, "end": 72}, {"text": "PKC", "start": 156, "end": 159}]}}, "schema": []}
{"input": "Interestingly, Csx/Nkx2.", "output": {"entities": {"gene": [{"text": "Csx", "start": 15, "end": 18}, {"text": "Nkx2", "start": 19, "end": 23}]}}, "schema": []}
{"input": "We also identified an alternative spliced form of Lyp RNA, Lyp2.", "output": {"entities": {"gene": [{"text": "Lyp RNA", "start": 50, "end": 57}, {"text": "Lyp2", "start": 59, "end": 63}]}}, "schema": []}
{"input": "The costs were DM 11, 562 for a PE, DM 12, 477 for a VR and DM 7, 532 for a MR.", "output": {"entities": {}}, "schema": []}
{"input": "We now provide evidence for physical and functional interaction between Doa4 and the proteasome.", "output": {"entities": {"gene": [{"text": "Doa4", "start": 72, "end": 76}]}}, "schema": []}
{"input": "Nipponbare as well as O. australiensis.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, mapping of the promoter region and the identification of putative promoter regulatory sequences should give insight into the transcriptional regulation of UCP2 expression--in particular by anyone of the above mentioned factors--in vitro and in vivo.", "output": {"entities": {"gene": [{"text": "UCP2", "start": 168, "end": 172}]}}, "schema": []}
{"input": "The rate of resectability is low and 5-year survival is very poor.", "output": {"entities": {}}, "schema": []}
{"input": "In order to better characterize the distribution of ML and MAP estimates under these conditions, we derive a point approximation to density values of the conditional distribution of such estimates.", "output": {"entities": {}}, "schema": []}
{"input": "RT-PCR was performed using previously reported degenerate oligonucleotide primers to the ligand binding domain (LBD) of known beta integrin subunits and Bge cDNA.", "output": {"entities": {"gene": [{"text": "beta integrin subunits", "start": 126, "end": 148}, {"text": "Bge cDNA", "start": 153, "end": 161}]}}, "schema": []}
{"input": "The lowest culture failure rate of 0. 2 per cent was found after EAF compared with 0. 9 per cent among CVS.", "output": {"entities": {}}, "schema": []}
{"input": "Ectopic expression of d-axin inhibited Wingless signaling.", "output": {"entities": {"gene": [{"text": "d-axin", "start": 22, "end": 28}, {"text": "Wingless", "start": 39, "end": 47}]}}, "schema": []}
{"input": "The corresponding differences in FVIIa and PAI-1 were not statistically significant.", "output": {"entities": {"gene": [{"text": "FVIIa", "start": 33, "end": 38}, {"text": "PAI-1", "start": 43, "end": 48}]}}, "schema": []}
{"input": "On the other side, when the aortic ring was perfused with L-NNA (NO-synthesis inhibitor) or methylene blue (soluble cGMPase inhibitor), the changes could be attenuated.", "output": {"entities": {"gene": [{"text": "cGMPase", "start": 116, "end": 123}]}}, "schema": []}
{"input": "Nevertheless, inactivation of the cyclin E-Cdk2 complex in response to mitogen starvation occurs normally in MEFs that have a homozygous deletion of the p27 gene.", "output": {"entities": {"gene": [{"text": "cyclin E", "start": 34, "end": 42}, {"text": "Cdk2", "start": 43, "end": 47}, {"text": "p27 gene", "start": 153, "end": 161}]}}, "schema": []}
{"input": "Identification and characterization of IS2404 and IS2606: two distinct repeated sequences for detection of Mycobacterium ulcerans by PCR.", "output": {"entities": {"gene": [{"text": "IS2404", "start": 39, "end": 45}, {"text": "IS2606", "start": 50, "end": 56}]}}, "schema": []}
{"input": "Taken together, these results are consistent with the possibility that p202 protein contributes to the cell growth retardation activity of the IFNs, at least in part, by modulating p21 protein levels.", "output": {"entities": {"gene": [{"text": "p202 protein", "start": 71, "end": 83}, {"text": "IFNs", "start": 143, "end": 147}, {"text": "p21 protein", "start": 181, "end": 192}]}}, "schema": []}
{"input": "Similar results were also obtained with a HepG2 hepatoblastoma cell line carrying wt p53.", "output": {"entities": {"gene": [{"text": "wt p53", "start": 82, "end": 88}]}}, "schema": []}
{"input": "Partial sequencing of the region downstream of ORF-Pto revealed homology to the ru/AB genes, involved in UV resistance, from plasmid pPSR1.", "output": {"entities": {"gene": [{"text": "ORF-Pto", "start": 47, "end": 54}, {"text": "ru/AB genes", "start": 80, "end": 91}]}}, "schema": []}
{"input": "The MSY2 associated kinase is not casein kinase 2, the kinase believed to phosphorylate mRNP3 + 4 in oocytes, but a yet unidentified kinase.", "output": {"entities": {"gene": [{"text": "MSY2", "start": 4, "end": 8}, {"text": "casein kinase 2", "start": 34, "end": 49}, {"text": "mRNP3 + 4", "start": 88, "end": 97}]}}, "schema": []}
{"input": "This suggests that helicase-like genes may be involved in the biosynthesis of nucleic acids and proteins, and that the genes can be transcriptionally activated by heat shock to compensate for the repressed synthesis of mRNA and protein.", "output": {"entities": {"gene": [{"text": "helicase-like genes", "start": 19, "end": 38}]}}, "schema": []}
{"input": "These data provide the molecular tools for the final identification of the MKS and the MUL genes.", "output": {"entities": {"gene": [{"text": "MKS", "start": 75, "end": 78}, {"text": "MUL genes", "start": 87, "end": 96}]}}, "schema": []}
{"input": "The origins of reflected light changes associated with neuronal activity (optical signals) were investigated in rat somatosensory cortex with optical imaging, microspectrophotometry, and laser-Doppler flowmetry, and dynamic changes in local hemoglobin concentration and oxygenation were focused on.", "output": {"entities": {"gene": [{"text": "hemoglobin", "start": 241, "end": 251}]}}, "schema": []}
{"input": "Human neuronal Elav-like proteins contain three RNP-type RNA recognition motifs (RRMs).", "output": {"entities": {"gene": [{"text": "Human neuronal Elav-like proteins", "start": 0, "end": 33}]}}, "schema": []}
{"input": "Comparison of frequencies of atrial fibrillation after coronary artery bypass grafting with and without the use of cardiopulmonary bypass.", "output": {"entities": {}}, "schema": []}
{"input": "The results of supershift analysis using specific antibodies against transcription factors suggested that both binding complexes contained the NF-kappaB components p50 and p65, and did not contain other NF-kappaB proteins (p52, c-Rel, Rel B), AP-1 proteins (c-Fos, C-Jun), CREB or C/EBPbeta (NF-IL6).", "output": {"entities": {"gene": [{"text": "NF-kappaB", "start": 143, "end": 152}, {"text": "p50", "start": 164, "end": 167}, {"text": "p65", "start": 172, "end": 175}, {"text": "NF-kappaB proteins", "start": 203, "end": 221}, {"text": "p52", "start": 223, "end": 226}, {"text": "c-Rel", "start": 228, "end": 233}, {"text": "Rel B", "start": 235, "end": 240}, {"text": "AP-1 proteins", "start": 243, "end": 256}, {"text": "c-Fos", "start": 258, "end": 263}, {"text": "C-Jun", "start": 265, "end": 270}, {"text": "CREB", "start": 273, "end": 277}, {"text": "C/EBPbeta", "start": 281, "end": 290}, {"text": "NF-IL6", "start": 292, "end": 298}]}}, "schema": []}
{"input": "A set of peptides corresponding to the individual elements of secondary structure derived from the N-terminal domain of the ribosomal protein L9 have been synthesized.", "output": {"entities": {"gene": [{"text": "ribosomal protein L9", "start": 124, "end": 144}]}}, "schema": []}
{"input": "The results showed that IFN-gamma stimulated the rapid accumulation of interferon regulated factor (IRF)-1 mRNA, followed by a delayed and dose-dependent inhibition of alpha1 (I) procollagen mRNA expression in skin fibroblasts from several different donors.", "output": {"entities": {"gene": [{"text": "IFN-gamma", "start": 24, "end": 33}, {"text": "interferon regulated factor (IRF)-1 mRNA", "start": 71, "end": 111}, {"text": "alpha1 (I) procollagen mRNA", "start": 168, "end": 195}]}}, "schema": []}
{"input": "Functional domains of c-myc promoter binding protein 1 involved in transcriptional repression and cell growth regulation.", "output": {"entities": {"gene": [{"text": "c-myc promoter binding protein 1", "start": 22, "end": 54}]}}, "schema": []}
{"input": "Therefore, we have named this gene UBP43.", "output": {"entities": {"gene": [{"text": "UBP43", "start": 35, "end": 40}]}}, "schema": []}
{"input": "These results continue to support the hypothesis that HS2, HS3, and HS4 act as a single, integral unit to regulate human globin gene transcription as a holocomplex, but they can also be interpreted to say that formation of a DNase I hypersensitive holocomplex alone is not sufficient for mediating high-level globin gene transcription.", "output": {"entities": {"gene": [{"text": "human globin gene", "start": 115, "end": 132}, {"text": "DNase I", "start": 225, "end": 232}, {"text": "globin gene", "start": 309, "end": 320}]}}, "schema": []}
{"input": "Because there is great need for iron in the EPO-stimulated erythroid progenitors, it is essential that serum ferritin and transferrin saturation levels should be maintained over 300 microg/liter and 30%, respectively.", "output": {"entities": {"gene": [{"text": "EPO", "start": 44, "end": 47}, {"text": "serum ferritin", "start": 103, "end": 117}, {"text": "transferrin", "start": 122, "end": 133}]}}, "schema": []}
{"input": "These results indicate that the p33 subunit of eIF3 plays an important role in the initiation phase of protein synthesis and that its RNA-binding domain is required for optimal activity.", "output": {"entities": {"gene": [{"text": "p33 subunit", "start": 32, "end": 43}, {"text": "eIF3", "start": 47, "end": 51}]}}, "schema": []}
{"input": "KEY WORDS: Melaleuca; Lake Okeechobee; Littoral zone; Water level; Regulation schedule", "output": {"entities": {}}, "schema": []}
{"input": "The systolic peak of pulmonary vein was higher than the diastolic peak in 45 out of 56 cases.", "output": {"entities": {}}, "schema": []}
{"input": "Specimens were assayed for alpha-fetoprotein, unconjugated estriol, free alpha hCG, and total hCG.", "output": {"entities": {"gene": [{"text": "alpha-fetoprotein", "start": 27, "end": 44}, {"text": "alpha hCG", "start": 73, "end": 82}, {"text": "hCG", "start": 94, "end": 97}]}}, "schema": []}
{"input": "The following data were recorded at arrival in the intensive care unit 6, 12, 24, and 48 hours after termination of CPB: heart rate, blood pressure, left atrial pressure, central-peripheral temperature difference, arterial-central venous oxygen saturation difference, urine output, serum creatinine, lactate and neutrophil elastase levels, the Doppler echocardiographic factors shortening fraction and preejection period/left-ventricular ejection time, and cumulative doses of catecholamines (epinephrine), enoximone, and furosemide.", "output": {"entities": {"gene": [{"text": "neutrophil elastase", "start": 312, "end": 331}]}}, "schema": []}
{"input": "MDS1/EVI1, located on chromosome 3 band q26, encodes a zinc-finger DNA-binding transcription activator not detected in normal hematopoietic cells but expressed in several normal tissues.", "output": {"entities": {"gene": [{"text": "MDS1", "start": 0, "end": 4}, {"text": "EVI1", "start": 5, "end": 9}, {"text": "zinc-finger DNA-binding transcription activator", "start": 55, "end": 102}]}}, "schema": []}
{"input": "The JTc delta among the three groups did not differ as well: JTc delta of the VT group was 70 ms +/-30 ms, the JTc delta of the PVC group was 60 msec +/-25 msec, and the JTc delta of the control group was 70 ms +/-30 ms.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast, deletion of the upstream portion of the delta promoter led to a 10 fold decrease in expression.", "output": {"entities": {}}, "schema": []}
{"input": "Site-directed mutagenesis of binding sites for the repressor proteins BP1 and BP2 in the upstream portion of the beta globin gene flanking region led to a 4-6 fold increase in promoter activity.", "output": {"entities": {"gene": [{"text": "repressor proteins BP1", "start": 51, "end": 73}, {"text": "BP2", "start": 78, "end": 81}, {"text": "beta globin gene flanking region", "start": 113, "end": 145}]}}, "schema": []}
{"input": "However, with the alpha1 antagonist prazosin (5 x 10 (-8)-5 x 10 (-7) M), no relaxation occurred.", "output": {"entities": {}}, "schema": []}
{"input": "Differential expression of AP-2alpha and AP-2beta in the developing chick retina: repression of R-FABP promoter activity by AP-2.", "output": {"entities": {"gene": [{"text": "AP-2alpha", "start": 27, "end": 36}, {"text": "AP-2beta", "start": 41, "end": 49}, {"text": "R-FABP promoter", "start": 96, "end": 111}, {"text": "AP-2", "start": 124, "end": 128}]}}, "schema": []}
{"input": "The mean value of the CD79b to the CD79b internally deleted ratio was 0. 64 +/-0. 20 SD in normal donors and 0. 44 +/-0. 27 SD in B-CLL (P =. 01).", "output": {"entities": {"gene": [{"text": "CD79b", "start": 22, "end": 27}, {"text": "CD79b", "start": 35, "end": 40}]}}, "schema": []}
{"input": "As normal B cells also present this variant, the mechanism of CD79b posttranscriptional regulation might reflect the activation stage of the normal B cell from which B-CLL derives.", "output": {"entities": {"gene": [{"text": "CD79b", "start": 62, "end": 67}]}}, "schema": []}
{"input": "High-level gains (HLGs) indicative of gene amplifications were identified at 11q13 in two cases, and in one case each at 2q33-34, 3q25-29, 5p15. 1-15. 2, 7q21-22, 11p11. 2, 12p11. 2-12, and 13q34.", "output": {"entities": {}}, "schema": []}
{"input": "With respect to the distribution of active MREs over the promoter region, the hMT-IIA gene is largely different from the mouse metallothionein-I gene, suggesting that MRE arrangement is not an important factor for metal regulation.", "output": {"entities": {"gene": [{"text": "hMT-IIA gene", "start": 78, "end": 90}, {"text": "metallothionein-I gene", "start": 127, "end": 149}]}}, "schema": []}
{"input": "The cDNA was expressed in Saccharomyces cerevisiae under the control of the yeast triose phosphate isomerase promoter.", "output": {"entities": {"gene": [{"text": "yeast triose phosphate isomerase promoter", "start": 76, "end": 117}]}}, "schema": []}
{"input": "Interestingly, the RNA sequences selected by the mutated zinc knuckle 9G8 variant are efficiently recognized by SRp20, in agreement with the fact that the RBD of 9G8 and SRp20 are similar.", "output": {"entities": {"gene": [{"text": "zinc knuckle 9G8 variant", "start": 57, "end": 81}, {"text": "SRp20", "start": 112, "end": 117}, {"text": "9G8", "start": 162, "end": 165}, {"text": "SRp20", "start": 170, "end": 175}]}}, "schema": []}
{"input": "Topoisomerase II is a major target of the protein kinase casein kinase 2 (PK CK2) in vivo.", "output": {"entities": {"gene": [{"text": "Topoisomerase II", "start": 0, "end": 16}, {"text": "protein kinase casein kinase 2", "start": 42, "end": 72}, {"text": "PK CK2", "start": 74, "end": 80}]}}, "schema": []}
{"input": "Recent work in this laboratory has shown that the gene coding for acetate kinase (ackA) in Sinorhizobium meliloti is up-regulated in response to phosphate limitation.", "output": {"entities": {"gene": [{"text": "acetate kinase", "start": 66, "end": 80}, {"text": "ackA", "start": 82, "end": 86}]}}, "schema": []}
{"input": "All numbers refer to nucleotide positions on the wild-type HIV-1 transcript.", "output": {"entities": {}}, "schema": []}
{"input": "Here, we report the complete structure of the human topoisomerase IIalpha gene, which consists of 35 exons spanning 27. 5 kb.", "output": {"entities": {"gene": [{"text": "human topoisomerase IIalpha gene", "start": 46, "end": 78}]}}, "schema": []}
{"input": "Previous studies characterized a cytokine-inducible, functional nuclear factor (NF)-kappaB consensus element in the immediate 5' regulatory region of the MGSA/GRO-alpha gene at-78 bp.", "output": {"entities": {"gene": [{"text": "nuclear factor (NF)-kappaB consensus element", "start": 64, "end": 108}, {"text": "MGSA", "start": 154, "end": 158}, {"text": "GRO-alpha", "start": 159, "end": 168}]}}, "schema": []}
{"input": "An exon that prevents transport of a mature mRNA.", "output": {"entities": {}}, "schema": []}
{"input": "Four CsA-treated patients developed persistently elevated UAER > 30 mg/24 h (n = 3 with microalbuminuria), whereas all the 17 placebo-treated patients had normal UAER (< 30 mg/24 h) after 7 years of follow-up.", "output": {"entities": {}}, "schema": []}
{"input": "Mutational analysis of the-84/-55 DNA showed that JEG-3 nuclear proteins bound to a site containing, but not identical to, the SF-1 sequence.", "output": {"entities": {"gene": [{"text": "SF-1 sequence", "start": 127, "end": 140}]}}, "schema": []}
{"input": "In contrast, no change was detected in the phenotype of' unstressed' clones, with respect to any of the following parameters: proliferation rate in monolayer, serum-dependence for proliferation or survival, tumorigenicity, cellular morphology, or tissue-specific differentiation markers.", "output": {"entities": {}}, "schema": []}
{"input": "A high reactor pH (+/-8), a short solid retention time (< 150 days), and the presence of a substantial SRB population in the inoculum may considerably reduce the time required for acetate-utilising SRB to outcompete MB.", "output": {"entities": {}}, "schema": []}
{"input": "In throttling valves, the aim is to correlate the effect of shear to a parameter related to the inner geometry of the valve and to operating conditions.", "output": {"entities": {}}, "schema": []}
{"input": "A mutation linked to the SOC1 gene, previously defined by recessive mutations that suppress cbp1 ts alleles and stabilize many mitochondrial mRNAs, was also isolated.", "output": {"entities": {"gene": [{"text": "SOC1 gene", "start": 25, "end": 34}, {"text": "cbp1 ts alleles", "start": 92, "end": 107}]}}, "schema": []}
{"input": "A deletion mutation analysis of the recombinant protein has shown that the N-terminal region and the two leucine zippers are necessary for the binding.", "output": {"entities": {}}, "schema": []}
{"input": "A database search has revealed as the most significative homology a match with the human mitochondrial transcription termination factor (mTERF), a protein that also binds DNA as a monomer and contains three leucine zippers forming intramolecular interactions.", "output": {"entities": {"gene": [{"text": "human mitochondrial transcription termination factor", "start": 83, "end": 135}, {"text": "mTERF", "start": 137, "end": 142}]}}, "schema": []}
{"input": "In all trials, antigen challenge followed 1 h after the last treatment.", "output": {"entities": {}}, "schema": []}
{"input": "31, 1997, 40 patients had died (35 in the ERA-II group and 5 in the ERA-III group), for a crude mortality rate of 8. 0%.", "output": {"entities": {}}, "schema": []}
{"input": "We found that total PSA can be detected in all cyst fluids and in about 75% of female sera.", "output": {"entities": {"gene": [{"text": "PSA", "start": 20, "end": 23}]}}, "schema": []}
{"input": "Type I cysts (with a high K +/Na + ratio) tend to have higher total PSA than Type II cysts.", "output": {"entities": {"gene": [{"text": "PSA", "start": 68, "end": 71}]}}, "schema": []}
{"input": "Despite this DNA binding activity, AP-1 reporter activity was suppressed in these cells.", "output": {"entities": {"gene": [{"text": "AP-1 reporter", "start": 35, "end": 48}]}}, "schema": []}
{"input": "A single N-glycosylation site present in chicken gp42 is conserved among all five of these proteins: carbohydrate analysis of gp42 revealed the presence of a complex type glycan chain at this site.", "output": {"entities": {"gene": [{"text": "chicken gp42", "start": 41, "end": 53}, {"text": "gp42", "start": 126, "end": 130}]}}, "schema": []}
{"input": "Here we describe the optimization and characterization of a 140-residue fragment, containing the Runt domain of AML1, which is suitable for structural studies.", "output": {"entities": {"gene": [{"text": "Runt domain", "start": 97, "end": 108}, {"text": "AML1", "start": 112, "end": 116}]}}, "schema": []}
{"input": "Judge OKs docs' bid for Chicago hospital.", "output": {"entities": {}}, "schema": []}
{"input": "HANYS criticizes laparoscopic gall bladder guidelines.", "output": {"entities": {}}, "schema": []}
{"input": "Groups dicker for price breaks as anesthetic gas goes multi-source.", "output": {"entities": {}}, "schema": []}
{"input": "Troubled CareNetwork gets pact from largest teacher union in Wis.", "output": {"entities": {}}, "schema": []}
{"input": "Ultrasonography provides excellent intraoperative evaluation of spinal cord injury.", "output": {"entities": {}}, "schema": []}
{"input": "UPMC is not the only organization pursuing controlled NHBC organ procurement, however.", "output": {"entities": {}}, "schema": []}
{"input": "Because of concerns regarding blood transfusion-related communicable disease (eg, acquired immune deficiency syndrome and non-A, non-B hepatitis), there has been increasing research effort into postoperative hemorrhage related to cardiopulmonary bypass with extracorporeal circulation.", "output": {"entities": {}}, "schema": []}
{"input": "They contrast trends in fertility, life expectancy ratios, and gender differences in these countries with the Hispanic population of the United States.", "output": {"entities": {}}, "schema": []}
{"input": "Holger v.", "output": {"entities": {}}, "schema": []}
{"input": "Hospital hit for hiring AHERF physicians.", "output": {"entities": {}}, "schema": []}
{"input": "Overexpression of either DAP-1 or sentrin causes apoptosis of TNF-sensitive L929 fibroblast cell line, as well as TNF-resistant osteosarcoma cell line, U2OS.", "output": {"entities": {"gene": [{"text": "DAP-1", "start": 25, "end": 30}, {"text": "sentrin", "start": 34, "end": 41}, {"text": "TNF", "start": 62, "end": 65}, {"text": "TNF", "start": 114, "end": 117}]}}, "schema": []}
{"input": "This is in contrast to PPARgamma2, which was previously shown to be phosphorylated at a single site in a motif that is not homologous to the sites now described in PPARalpha.", "output": {"entities": {"gene": [{"text": "PPARgamma2", "start": 23, "end": 33}, {"text": "PPARalpha", "start": 164, "end": 173}]}}, "schema": []}
{"input": "These results suggest KCC3 is a new member of the KCC family that is under distinct regulation from KCC1.", "output": {"entities": {"gene": [{"text": "KCC3", "start": 22, "end": 26}, {"text": "KCC family", "start": 50, "end": 60}, {"text": "KCC1", "start": 100, "end": 104}]}}, "schema": []}
{"input": "We have screened the elastin gene for mutations responsible for supravalvular aortic stenosis (SVAS) in two large, independently collected families with isolated (nonsyndromic) SVAS.", "output": {"entities": {"gene": [{"text": "elastin gene", "start": 21, "end": 33}]}}, "schema": []}
{"input": "Spatiotemporal expression of the PAX3 gene is tightly regulated during development.", "output": {"entities": {"gene": [{"text": "PAX3 gene", "start": 33, "end": 42}]}}, "schema": []}
{"input": "A list of 12 names for the disease and 37 diagnostic criteria were proposed to a Consensus Panel of 12 Italian experts who ranked them in order so as to identify a core set of criteria.", "output": {"entities": {}}, "schema": []}
{"input": "Methanesulfonyl fluoride (MSF): a double-blind, placebo-controlled study of safety and efficacy in the treatment of senile dementia of the Alzheimer type.", "output": {"entities": {}}, "schema": []}
{"input": "METHODS: Between August 1991 and June 1994, 198 men with clinical T2 or T3 classified (TNM) prostate carcinoma (bone scan negative) who were at high risk of lymph node involvement underwent a 111In-capromab pendetide scan prior to staging lymphadenectomy.", "output": {"entities": {}}, "schema": []}
{"input": "Voluntary wheel running did not significantly increase estimated alanine or pyruvate Gneo or absolute glycerol Ra.", "output": {"entities": {}}, "schema": []}
{"input": "Immediately after surgery, dialysate PGE2 and adenosine concentrations were 3. 7 +/-0. 7 and 296 +/-127 nM, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Because of the probable causal relationship between constitutive p210 (bcr/abl) protein tyrosine kinase activity and manifestations of chronic-phase chronic myelogenous leukemia (CML; myeloid expansion), a key goal is to identify relevant p210 substrates in primary chronic-phase CML hematopoietic progenitor cells.", "output": {"entities": {"gene": [{"text": "p210", "start": 65, "end": 69}, {"text": "bcr", "start": 71, "end": 74}, {"text": "abl", "start": 75, "end": 78}, {"text": "protein tyrosine kinase", "start": 80, "end": 103}, {"text": "p210", "start": 239, "end": 243}]}}, "schema": []}
{"input": "In vitro precipitation with a glutathione-S-transferase-fusion protein containing the C-terminal transactivation domain of STAT5a showed GH-regulated association of ERK1/2 with the fusion protein, while this was not seen when serine 780 in STAT5a was changed to alanine.", "output": {"entities": {"gene": [{"text": "glutathione-S-transferase-fusion protein", "start": 30, "end": 70}, {"text": "STAT5a", "start": 123, "end": 129}, {"text": "GH", "start": 137, "end": 139}, {"text": "ERK1/2", "start": 165, "end": 171}, {"text": "STAT5a", "start": 240, "end": 246}]}}, "schema": []}
{"input": "One such element, 1P, was employed to clone from a rat pituitary cDNA expression library a novel 417-amino acid WD protein, designated PREB (PRL regulatory element binding) protein.", "output": {"entities": {"gene": [{"text": "417-amino acid WD protein", "start": 97, "end": 122}, {"text": "PREB (PRL regulatory element binding) protein", "start": 135, "end": 180}]}}, "schema": []}
{"input": "Characterization of the transcription factor MTF-1 from the Japanese pufferfish (Fugu rubripes) reveals evolutionary conservation of heavy metal stress response.", "output": {"entities": {"gene": [{"text": "transcription factor MTF-1", "start": 24, "end": 50}]}}, "schema": []}
{"input": "The peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily.", "output": {"entities": {"gene": [{"text": "peroxisome proliferator-activated receptors", "start": 4, "end": 47}, {"text": "PPARs", "start": 49, "end": 54}, {"text": "nuclear hormone receptor superfamily", "start": 75, "end": 111}]}}, "schema": []}
{"input": "However, F-SRC-1 mutant lacking CBP-interacting domain still preserved enhancing activity.", "output": {"entities": {"gene": [{"text": "F-SRC-1 mutant", "start": 9, "end": 23}, {"text": "CBP-interacting domain", "start": 32, "end": 54}]}}, "schema": []}
{"input": "The catalytic site has an S1 pocket lined with conserved hydrophobic residues to accommodate the pyroglutamyl residue.", "output": {"entities": {}}, "schema": []}
{"input": "The complete circular TTV genome contained a novel sequence of 113 nt (nt 3740 to 3852 [= 0]) in between the known 3'-and 5'-end arms, forming a 117-nt GC-rich stretch (GC content, 90. 6% at nt 3736 to 3852).", "output": {"entities": {}}, "schema": []}
{"input": "The Asian mouse Mus castaneus is resistant to infection by the polytropic mink cell focus-inducing (MCF) subgroup of murine leukemia viruses (MuLVs).", "output": {"entities": {}}, "schema": []}
{"input": "To determine the function of VZV gK in virus growth, a series of gK deletion mutants were constructed with VZV cosmid DNA derived from the Oka strain.", "output": {"entities": {"gene": [{"text": "VZV gK", "start": 29, "end": 35}, {"text": "gK deletion mutants", "start": 65, "end": 84}]}}, "schema": []}
{"input": "CCAAT displacement protein binds to and negatively regulates human papillomavirus type 6 E6, E7, and E1 promoters.", "output": {"entities": {"gene": [{"text": "CCAAT displacement protein", "start": 0, "end": 26}, {"text": "E6", "start": 89, "end": 91}, {"text": "E7", "start": 93, "end": 95}, {"text": "E1", "start": 101, "end": 103}]}}, "schema": []}
{"input": "Three different site-directed mutations of the cyclic AMP response element each reduced the nerve growth factor effect by > 90%.", "output": {"entities": {"gene": [{"text": "nerve growth factor", "start": 92, "end": 111}]}}, "schema": []}
{"input": "Using an RNase H protection assay and specific blocking oligonucleotides, we find that recognition of the 5' splice-site (5' ss) and branchpoint sequence (BPS) elements by U11 and U12 snRNPs, respectively, displays strong cooperativity, requiring both sites in the pre-mRNA substrate for efficient complex formation.", "output": {"entities": {"gene": [{"text": "RNase H", "start": 9, "end": 16}, {"text": "U11", "start": 172, "end": 175}, {"text": "U12 snRNPs", "start": 180, "end": 190}]}}, "schema": []}
{"input": "Many eukaryotic cell surface proteins are anchored in the lipid bilayer through glycosylphosphatidylinositol (GPI).", "output": {"entities": {}}, "schema": []}
{"input": "An endogenous mammalian regulator of this process, named Usurpin, has been identified (aliases for Usurpin include CASH, Casper, CLARP, FLAME-1, FLIP, I-FLICE and MRIT).", "output": {"entities": {"gene": [{"text": "Usurpin", "start": 57, "end": 64}, {"text": "Usurpin", "start": 99, "end": 106}, {"text": "CASH", "start": 115, "end": 119}, {"text": "Casper", "start": 121, "end": 127}, {"text": "CLARP", "start": 129, "end": 134}, {"text": "FLAME-1", "start": 136, "end": 143}, {"text": "FLIP", "start": 145, "end": 149}, {"text": "I-FLICE", "start": 151, "end": 158}, {"text": "MRIT", "start": 163, "end": 167}]}}, "schema": []}
{"input": "Plasma glucose, immunoreactive insulin (IRI), C-peptide, glucagon, and GLP-1 levels at each time point during OGTT were measured.", "output": {"entities": {"gene": [{"text": "immunoreactive insulin", "start": 16, "end": 38}, {"text": "IRI", "start": 40, "end": 43}, {"text": "C-peptide", "start": 46, "end": 55}, {"text": "glucagon", "start": 57, "end": 65}, {"text": "GLP-1", "start": 71, "end": 76}]}}, "schema": []}
{"input": "Technetium-99m methylene diphosphonate scintimammography for evaluation of palpable breast masses.", "output": {"entities": {}}, "schema": []}
{"input": "Nuclear receptors (NRs) can function as ligandinducible transregulators in both mammalian and yeast cells, indicating that important features of transcriptional control have been conserved throughout evolution.", "output": {"entities": {}}, "schema": []}
{"input": "When tethered to a heterologous DNA-binding domain, PSU1 can activate transcription on its own.", "output": {"entities": {"gene": [{"text": "PSU1", "start": 52, "end": 56}]}}, "schema": []}
{"input": "OBJECTIVE: To follow-up prospectively patients with arthritis after infection with beta-haemolytic streptococci of Lancefield group A (beta HSA), with emphasis on clinical characteristics and serological features.", "output": {"entities": {}}, "schema": []}
{"input": "We found that the expression of the protein was maximum in mitosis and minimum in G1, which correlated with the expression of its messenger RNA.", "output": {"entities": {}}, "schema": []}
{"input": "These findings demonstrate that signature-tagged mutagenesis is a viable approach to identify bacterial genes associated with the ability to infect the urinary tract.", "output": {"entities": {}}, "schema": []}
{"input": "Pathol.", "output": {"entities": {}}, "schema": []}
{"input": "The eukaryotic cell cycle is governed in part by the periodic transcription of cyclin genes, whose protein products associate with and positively regulate the cyclin-dependent kinases.", "output": {"entities": {"gene": [{"text": "cyclin genes", "start": 79, "end": 91}, {"text": "cyclin-dependent kinases", "start": 159, "end": 183}]}}, "schema": []}
{"input": "The GAC1 gene encodes the regulatory subunit for a type 1 serine/threonine phosphoprotein phosphatase, Glc7.", "output": {"entities": {"gene": [{"text": "GAC1 gene", "start": 4, "end": 13}, {"text": "type 1 serine/threonine phosphoprotein phosphatase", "start": 51, "end": 101}, {"text": "Glc7", "start": 103, "end": 107}]}}, "schema": []}
{"input": "The results demonstrate that the Glc7 phosphatase and its Gac1 regulatory subunit play positive roles in HSF activation of CUP1 transcription.", "output": {"entities": {"gene": [{"text": "Glc7 phosphatase", "start": 33, "end": 49}, {"text": "Gac1", "start": 58, "end": 62}, {"text": "HSF", "start": 105, "end": 108}, {"text": "CUP1", "start": 123, "end": 127}]}}, "schema": []}
{"input": "MEF and AML1B synergistically transactivated an interleukin 3 promoter reporter gene construct, yet the activating activity of MEF was abolished when MEF was coexpressed with AML1/ETO.", "output": {"entities": {"gene": [{"text": "MEF", "start": 0, "end": 3}, {"text": "AML1B", "start": 8, "end": 13}, {"text": "interleukin 3 promoter reporter gene construct", "start": 48, "end": 94}, {"text": "MEF", "start": 127, "end": 130}, {"text": "MEF", "start": 150, "end": 153}, {"text": "AML1", "start": 175, "end": 179}, {"text": "ETO", "start": 180, "end": 183}]}}, "schema": []}
{"input": "Mechanistically, the presence of the GRR appears to stop further degradation of p50 and to stabilize the molecule.", "output": {"entities": {"gene": [{"text": "p50", "start": 80, "end": 83}]}}, "schema": []}
{"input": "This phosphorylation can be catalyzed by a break-ended double-stranded DNA-activated protein kinase activity from the sea urchin nucleus in vitro.", "output": {"entities": {}}, "schema": []}
{"input": "Concomitantly, the total cellular level of p21 increased severalfold via a posttranscriptional mechanism.", "output": {"entities": {"gene": [{"text": "p21", "start": 43, "end": 46}]}}, "schema": []}
{"input": "Moreover, when added to the osteoclast cultures, mrIhh-N markedly stimulated the formation of resorption pits on dentine slices.", "output": {"entities": {"gene": [{"text": "mrIhh-N", "start": 49, "end": 56}]}}, "schema": []}
{"input": "Overall, our results suggest that resistant genotypes exist among the WAD goat population.", "output": {"entities": {}}, "schema": []}
{"input": "The molecular mechanism by which Gle2p and the Gle2p-Nup116p interaction function in mRNA export is unknown.", "output": {"entities": {"gene": [{"text": "Gle2p", "start": 33, "end": 38}, {"text": "Gle2p", "start": 47, "end": 52}, {"text": "Nup116p", "start": 53, "end": 60}]}}, "schema": []}
{"input": "The Fyn NH2 terminus was necessary but not sufficient for interaction with zeta and both Fyn kinase and SH2 domains were required, directing phosphorylation of zeta ITAM tyrosines and binding to zeta ITAM phosphotyrosines.", "output": {"entities": {"gene": [{"text": "Fyn NH2 terminus", "start": 4, "end": 20}, {"text": "Fyn kinase", "start": 89, "end": 99}, {"text": "SH2 domains", "start": 104, "end": 115}, {"text": "zeta ITAM", "start": 160, "end": 169}, {"text": "zeta ITAM", "start": 195, "end": 204}]}}, "schema": []}
{"input": "In budding yeast, the protein Skp1p, the cullin-family member Cdc53p, and the F-box/WD-repeat protein Cdc4p form the SCFCdc4p ubiquitin ligase complex, which targets the cyclin-dependent kinase (Cdk) inhibitor Sic1p for proteolysis [3] [4] [5] [6] [7] [8].", "output": {"entities": {"gene": [{"text": "Skp1p", "start": 30, "end": 35}, {"text": "cullin-family member Cdc53p", "start": 41, "end": 68}, {"text": "Cdc4p", "start": 102, "end": 107}, {"text": "SCFCdc4p ubiquitin ligase", "start": 117, "end": 142}, {"text": "cyclin-dependent kinase", "start": 170, "end": 193}, {"text": "Cdk", "start": 195, "end": 198}, {"text": "Sic1p", "start": 210, "end": 215}]}}, "schema": []}
{"input": "We show here that, despite their structural and functional similarities, the pop1 and pop2 genes fail to complement each other' s deletion phenotypes, indicating that they perform non-redundant, but potentially interdependent, functions in proteolysis.", "output": {"entities": {"gene": [{"text": "pop1", "start": 77, "end": 81}, {"text": "pop2 genes", "start": 86, "end": 96}]}}, "schema": []}
{"input": "Antithrombin III prevents 60 min warm intestinal ischemia reperfusion injury in rats.", "output": {"entities": {"gene": [{"text": "Antithrombin III", "start": 0, "end": 16}]}}, "schema": []}
{"input": "In retrospect, the diagnoses were reconsidered applying strict criteria.", "output": {"entities": {}}, "schema": []}
{"input": "These observations of elevated serum lipase and serum CA 19-9 in Sjogren' s syndrome without evidence of malignancy may reflect pancreatic involvement in this disorder.", "output": {"entities": {"gene": [{"text": "serum lipase", "start": 31, "end": 43}, {"text": "CA 19-9", "start": 54, "end": 61}]}}, "schema": []}
{"input": "Acute pancreatitis as a complication of polyarteritis nodosa.", "output": {"entities": {}}, "schema": []}
{"input": "Significantly greater improvement (p < 0. 05) in the sertraline group first became apparent by the end of week 3 on the Y-BOCS and the CGI Improvement scale, and by the end of weeks 6 and 8, respectively, on the NIMH and CGI Severity scale.", "output": {"entities": {}}, "schema": []}
{"input": "Stress-inducible protein kinases capable of activating c-jun expression include stress-activated protein kinase/c-Jun N-terminal protein kinase (SAPK/JNK) and p38 members of the mitogen-activated protein kinase (MAPK) superfamily of signaling molecules.", "output": {"entities": {"gene": [{"text": "Stress-inducible protein kinases", "start": 0, "end": 32}, {"text": "c-jun", "start": 55, "end": 60}, {"text": "stress-activated protein kinase", "start": 80, "end": 111}, {"text": "c-Jun N-terminal protein kinase", "start": 112, "end": 143}, {"text": "SAPK", "start": 145, "end": 149}, {"text": "JNK", "start": 150, "end": 153}, {"text": "p38", "start": 159, "end": 162}, {"text": "mitogen-activated protein kinase", "start": 178, "end": 210}, {"text": "MAPK", "start": 212, "end": 216}]}}, "schema": []}
{"input": "Transforming growth factor (TGF)-beta1 induces extracellular matrix deposition and proliferation of mesenchymal cells.", "output": {"entities": {"gene": [{"text": "Transforming growth factor (TGF)-beta1", "start": 0, "end": 38}]}}, "schema": []}
{"input": "Chronotherapeutics in cardiovascular disease.", "output": {"entities": {}}, "schema": []}
{"input": "Group psychometric functions for listeners with hearing loss do not show a decrease in performance at the largest values of delta f included in this study.", "output": {"entities": {}}, "schema": []}
{"input": "Uroflowmetry can detect dysuria, which may be poorly perceived or even unknown to the subjects themselves.", "output": {"entities": {}}, "schema": []}
{"input": "Marked racial variation in birthweight percentiles by gestational age was evident.", "output": {"entities": {}}, "schema": []}
{"input": "Significant correlations between mental status as measured by the Mini-Mental State Examination and NA/mI, mI/Cr and NA were found.", "output": {"entities": {}}, "schema": []}
{"input": "Glucagon also induced LUC activity very strongly when the CRE1 and CRE2 sites were combined; induction of the (CRE1) 3 (CRE2) 2SV40-LUC constructs was positively modulated by the pO2.", "output": {"entities": {"gene": [{"text": "Glucagon", "start": 0, "end": 8}, {"text": "LUC", "start": 22, "end": 25}, {"text": "LUC", "start": 132, "end": 135}]}}, "schema": []}
{"input": "In this study, we report the isolation and characterization of the entire rat GSTA3 (rGST Yc1) subunit gene.", "output": {"entities": {"gene": [{"text": "rat GSTA3", "start": 74, "end": 83}, {"text": "rGST Yc1", "start": 85, "end": 93}]}}, "schema": []}
{"input": "Calcinosis cutis following intravenous infusion of calcium gluconate.", "output": {"entities": {}}, "schema": []}
{"input": "Finally, we determined the genomic organization of the human TrxR2 gene, which consists of 18 exons spanning about 67 kb, and its chromosomal localization at position 22q11. 2.", "output": {"entities": {"gene": [{"text": "human TrxR2 gene", "start": 55, "end": 71}]}}, "schema": []}
{"input": "The aims of this study were to determine and rank the frequency of self reported visual disability in daily tasks performed by glaucoma patients; to examine the interrelation between disabilities using factor analysis; to study the relation between perceived visual difficulty and a measure of the severity of visual field loss; to develop a glaucoma specific subgroup of questions; and examine the validity and reliability of this subgroup of questions.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, the validity of this new subset of questions was shown to be significant (r = 0. 037, p < 0. 05) for the correlation between a measure of the severity of binocular visual field loss and the mean score of the variables used in the glaucoma specific subgroup of questions.", "output": {"entities": {}}, "schema": []}
{"input": "Sequence comparison of cytochromes bd and their homologs from various organisms demonstrates that the proteins can be classified into two subfamilies, a proteobacterial type including E. coli bd and a more widely distributed type including the B. stearothermophilus enzyme, suggesting that the latter type is evolutionarily older.", "output": {"entities": {"gene": [{"text": "cytochromes bd", "start": 23, "end": 37}, {"text": "E. coli bd", "start": 184, "end": 194}]}}, "schema": []}
{"input": "In 11 eyes that had been selected at random 10 micrograms of recombinant tissue plasminogen activator were injected midvitreally 24 hrs later.", "output": {"entities": {"gene": [{"text": "recombinant tissue plasminogen activator", "start": 61, "end": 101}]}}, "schema": []}
{"input": "RESULTS AND CONCLUSIONS: Brandt' s double cuff-tubes (G2) succeed in avoiding uncontrolled increase of cuff-pressure during anaesthesia with N2O.", "output": {"entities": {}}, "schema": []}
{"input": "Accordingly, we designated this gene CTL1 (capping enzyme RNAtriphosphatase-like 1).", "output": {"entities": {"gene": [{"text": "gene CTL1", "start": 32, "end": 41}, {"text": "capping enzyme RNAtriphosphatase-like 1", "start": 43, "end": 82}]}}, "schema": []}
{"input": "Their afterglows are brighter than supernovae and therefore are called hypernovae.", "output": {"entities": {}}, "schema": []}
{"input": "Constrictive pericarditis and pleuropulmonary disease linked to ergot dopamine agonist therapy (cabergoline) for Parkinson' s disease.", "output": {"entities": {}}, "schema": []}
{"input": "An undilated type of APBD is frequently associated with AMT and we believe, therefore, that clinicians should be aware of a possible coexistence of APBD and AMT.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, we also constructed and expressed chimeric fusion protein that contains HIV-2 gag with V3 domains of HIV-1IIIB, HIV-1MN, HIV-1SF2 and HIV-1RF.", "output": {"entities": {"gene": [{"text": "HIV-2 gag", "start": 85, "end": 94}, {"text": "V3", "start": 100, "end": 102}]}}, "schema": []}
{"input": "Our results indicate that V3 peptides from all major clades of HIV-1 carried by HIV-2 gag can be used as a potential HIV/AIDS vaccine.", "output": {"entities": {"gene": [{"text": "V3", "start": 26, "end": 28}, {"text": "HIV-2 gag", "start": 80, "end": 89}]}}, "schema": []}
{"input": "Efficacy was determined by responses to question 3 (ability to achieve an erection) and question 4 (ability to maintain an erection) of the 15-item International Index of Erectile Function (IIEF).", "output": {"entities": {}}, "schema": []}
{"input": "Evidence for the involvement of the Glc7-Reg1 phosphatase and the Snf1-Snf4 kinase in the regulation of INO1 transcription in Saccharomyces cerevisiae.", "output": {"entities": {"gene": [{"text": "Glc7", "start": 36, "end": 40}, {"text": "Reg1", "start": 41, "end": 45}, {"text": "Snf1", "start": 66, "end": 70}, {"text": "Snf4", "start": 71, "end": 75}, {"text": "INO1", "start": 104, "end": 108}]}}, "schema": []}
{"input": "In XO males, two her-1 mRNAs, her-1a and her-1b, are transcribed from two separate promoters: P1, located in the 5'-flanking region, and P2, located in the large second intron.", "output": {"entities": {"gene": [{"text": "her-1 mRNAs", "start": 17, "end": 28}, {"text": "her-1a", "start": 30, "end": 36}, {"text": "her-1b", "start": 41, "end": 47}]}}, "schema": []}
{"input": "Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain.", "output": {"entities": {"gene": [{"text": "Fas ligand", "start": 13, "end": 23}, {"text": "Nef", "start": 70, "end": 73}, {"text": "T cell receptor zeta chain", "start": 83, "end": 109}]}}, "schema": []}
{"input": "Receptor protein tyrosine phosphatases (RPTPs) comprise a family of proteins that feature intracellular phosphatase domains and an ectodomain with putative ligand-binding motifs.", "output": {"entities": {"gene": [{"text": "Receptor protein tyrosine phosphatases", "start": 0, "end": 38}, {"text": "RPTPs", "start": 40, "end": 45}]}}, "schema": []}
{"input": "These well-characterized brain regions may provide a basis for future studies of RPTP-kappa function.", "output": {"entities": {"gene": [{"text": "RPTP-kappa", "start": 81, "end": 91}]}}, "schema": []}
{"input": "Commonly used stressors are mental arithmetics, speech tasks, the Stroop test, videogame playing, films or videotapes and interviews.", "output": {"entities": {}}, "schema": []}
{"input": "The control group included 8 afterbirth samples from physiological full-term pregnancies.", "output": {"entities": {}}, "schema": []}
{"input": "However, we identified a gene between the MDV2 UL54 and UL55 genes with homology to the first ORF (ORF-1) of equine herpesvirus type 1 and corresponding gene identified in pseudorabies virus.", "output": {"entities": {"gene": [{"text": "MDV2 UL54", "start": 42, "end": 51}, {"text": "UL55 genes", "start": 56, "end": 66}, {"text": "first ORF (ORF-1) of equine herpesvirus type 1", "start": 88, "end": 134}]}}, "schema": []}
{"input": "In contrast, the loss of MAD2 staining in meiosis was not correlated with initial microtubule attachment but was correlated with a measure of tension: the distance between homologous or sister kinetochores (in meiosis I and II, respectively).", "output": {"entities": {"gene": [{"text": "MAD2", "start": 25, "end": 29}]}}, "schema": []}
{"input": "In epithelial cells, the PH domain of Akt/PKB localised to sites of cell-cell and cell-matrix contact, distinct from focal contacts, even in the absence of serum.", "output": {"entities": {"gene": [{"text": "PH domain", "start": 25, "end": 34}, {"text": "Akt", "start": 38, "end": 41}, {"text": "PKB", "start": 42, "end": 45}]}}, "schema": []}
{"input": "The 5' untranslated and coding regions are contained within 12 exons, with the translation start site located within the first exon.", "output": {"entities": {}}, "schema": []}
{"input": "The motility of sperm, except for those adjacent to both electrodes, did not change after stimulation for 60s, despite a high electrical energy.", "output": {"entities": {}}, "schema": []}
{"input": "Induction of the CINC promoter by IL-17 in IEC-6 cells was TNF receptor-associated factor-6 (TRAF6), but not TRAF2, dependent.", "output": {"entities": {"gene": [{"text": "CINC promoter", "start": 17, "end": 30}, {"text": "IL-17", "start": 34, "end": 39}, {"text": "TNF receptor-associated factor-6", "start": 59, "end": 91}, {"text": "TRAF6", "start": 93, "end": 98}, {"text": "TRAF2", "start": 109, "end": 114}]}}, "schema": []}
{"input": "SCFFWD1 may be critical for tumor development and suppression through regulation of beta-catenin protein stability.", "output": {"entities": {"gene": [{"text": "SCFFWD1", "start": 0, "end": 7}, {"text": "beta-catenin protein", "start": 84, "end": 104}]}}, "schema": []}
{"input": "A Bub2p-dependent spindle checkpoint pathway regulates the Dbf2p kinase in budding yeast.", "output": {"entities": {"gene": [{"text": "Bub2p", "start": 2, "end": 7}, {"text": "Dbf2p kinase in budding yeast", "start": 59, "end": 88}]}}, "schema": []}
{"input": "We analyzed the modular organization of DNA polymerase beta and found that residues making contact with DNA phosphates were localized to five modules.", "output": {"entities": {"gene": [{"text": "DNA polymerase beta", "start": 40, "end": 59}]}}, "schema": []}
{"input": "RESULTS: Cholinergic nerves are mainly involved in the regulation of enteric nerve responses to EFS in the normal IAS.", "output": {"entities": {}}, "schema": []}
{"input": "We show that other cdc33 mutants also arrest in G1.", "output": {"entities": {"gene": [{"text": "cdc33 mutants", "start": 19, "end": 32}]}}, "schema": []}
{"input": "A cdc33-1 strain expressing either stable Cln3p (Cln3-1p) or a hybrid UBI4 5'-CLN3 mRNA, whose translation displays decreased dependence on eIF4E, arrested randomly in the cell cycle.", "output": {"entities": {"gene": [{"text": "cdc33-1", "start": 2, "end": 9}, {"text": "Cln3p", "start": 42, "end": 47}, {"text": "Cln3-1p", "start": 49, "end": 56}, {"text": "UBI4 5'-CLN3", "start": 70, "end": 82}, {"text": "eIF4E", "start": 140, "end": 145}]}}, "schema": []}
{"input": "Regulatory motifs for gene expression such as nuclear-factor-kappaB-binding-site-like sequence (kappaB site) and nuclear-factor-interleukin-6-binding-site-like sequence (NF-IL-6 site) were found in the 5'-upstream regulatory region.", "output": {"entities": {"gene": [{"text": "nuclear-factor-kappaB-binding-site-like sequence", "start": 46, "end": 94}, {"text": "kappaB site", "start": 96, "end": 107}, {"text": "nuclear-factor-interleukin-6-binding-site-like sequence", "start": 113, "end": 168}, {"text": "NF-IL-6 site", "start": 170, "end": 182}]}}, "schema": []}
{"input": "Total serum calcium was 7. 8 +/-0. 8 mg/dl, whereas ionized calcium was 5. 7 +/-0. 7 mg/dl, phosphorus 3. 2 +/-1. 2 mg/dl, and alkaline phosphatase 149 +/-48. 6 U/liter.", "output": {"entities": {"gene": [{"text": "alkaline phosphatase", "start": 127, "end": 147}]}}, "schema": []}
{"input": "Cranio-caudal differences in granulation tissue formation: an experimental study in the rat.", "output": {"entities": {}}, "schema": []}
{"input": "Site-directed mutagenesis showed that two adjacent SP1 sites proximal to exon 1 were equally important in sustaining basal promoter activity.", "output": {"entities": {"gene": [{"text": "SP1 sites", "start": 51, "end": 60}]}}, "schema": []}
{"input": "Breast-fed newborn infants synthesize n-6 long-chain polyunsaturated fatty acids already during the first week of life, but the contribution of endogenous synthesis to the total plasma long-chain polyunsaturated pool is small.", "output": {"entities": {}}, "schema": []}
{"input": "Ischemia and reperfusion markedly increased the release of 6-keto-PGF1 alpha and TXB2.", "output": {"entities": {}}, "schema": []}
{"input": "Prostate-specific antigen (PSA) promoter-driven androgen-inducible expression of sodium iodide symporter in prostate cancer cell lines.", "output": {"entities": {"gene": [{"text": "Prostate-specific antigen", "start": 0, "end": 25}, {"text": "PSA", "start": 27, "end": 30}, {"text": "sodium iodide symporter", "start": 81, "end": 104}]}}, "schema": []}
{"input": "It is clear that subclinical and silent CD exist in a large subgroup of the celiac population.", "output": {"entities": {}}, "schema": []}
{"input": "Ras2p activates invasive growth using either of two downstream signaling pathways, the filamentation MAPK (Cdc42p/Ste20p/MAPK) cascade or the cAMP-dependent protein kinase (Cyr1p/cAMP/PKA) pathway.", "output": {"entities": {"gene": [{"text": "Ras2p", "start": 0, "end": 5}, {"text": "MAPK", "start": 101, "end": 105}, {"text": "Cdc42p", "start": 107, "end": 113}, {"text": "Ste20p", "start": 114, "end": 120}, {"text": "MAPK", "start": 121, "end": 125}, {"text": "cAMP-dependent protein kinase", "start": 142, "end": 171}, {"text": "Cyr1p", "start": 173, "end": 178}, {"text": "PKA", "start": 184, "end": 187}]}}, "schema": []}
{"input": "Consistent with this prediction, transfections into the hematopoietic cell line Jurkat showed a 9. 0-and 2. 5-fold activation of the mim-1 promoter by the p32 and p30 isoforms, respectively.", "output": {"entities": {"gene": [{"text": "mim-1 promoter", "start": 133, "end": 147}, {"text": "p32", "start": 155, "end": 158}, {"text": "p30 isoforms", "start": 163, "end": 175}]}}, "schema": []}
{"input": "Despite the reported detrimental effects on CNS development, a number of animal studies have shown that pretreatment with corticosteroids nevertheless protect the brain from hypoxia-ischemic injury; however, clinically such treatment is no longer favored.", "output": {"entities": {}}, "schema": []}
{"input": "In one mechanism, a specialized ubiquitin-dependent proteolytic system (called the APC-dependent proteolysis machinery) degrades the mitotic (Clb) cyclin subunit.", "output": {"entities": {"gene": [{"text": "ubiquitin", "start": 32, "end": 41}, {"text": "Clb", "start": 142, "end": 145}, {"text": "cyclin subunit", "start": 147, "end": 161}]}}, "schema": []}
{"input": "Predictors of success in pharmacy school: PCAT vs. other admission criteria.", "output": {"entities": {}}, "schema": []}
{"input": "Canadian survey reveals widespread dissatisfaction among physicians.", "output": {"entities": {}}, "schema": []}
{"input": "In a series of 16 full-scale fire tests, investigators at the IIT Research Institute have concluded that automatic door control in the room of fire origin can significantly reduce the spread of toxic smoke and gases.", "output": {"entities": {}}, "schema": []}
{"input": "Reporting of adverse events occurring during clinical trials of investigational drugs is a complex and controversial issue.", "output": {"entities": {}}, "schema": []}
{"input": "Medicare SNF benefits revised--again.", "output": {"entities": {}}, "schema": []}
{"input": "In this paper, the current status of the understanding of the interaction mechanisms of ultrasound with biological media and the factors that govern different biological effects are surveyed.", "output": {"entities": {}}, "schema": []}
{"input": "Members of the mitogen activated protein (MAP) kinase family, extracellular signal-regulated kinase, stress-activated protein kinase-1/c-Jun NH2-terminal kinase, and p38, are central elements that transduce the signal generated by growth factors, cytokines, and stressing agents.", "output": {"entities": {"gene": [{"text": "mitogen activated protein (MAP) kinase family", "start": 15, "end": 60}, {"text": "extracellular signal-regulated kinase", "start": 62, "end": 99}, {"text": "stress-activated protein kinase-1", "start": 101, "end": 134}, {"text": "c-Jun NH2-terminal kinase", "start": 135, "end": 160}, {"text": "p38", "start": 166, "end": 169}]}}, "schema": []}
{"input": "In the present study, we have investigated the functional role of the other MAP kinases in PDGF-mediated cellular responses.", "output": {"entities": {"gene": [{"text": "MAP kinases", "start": 76, "end": 87}, {"text": "PDGF", "start": 91, "end": 95}]}}, "schema": []}
{"input": "Analyses of tyrosine residue-mutated PDGF receptors show that Src homology 2 domain-containing proteins including Src family kinases, phosphatidylinositol 3-kinase, the GTPase-activating protein of Ras, the Src homology 2 domain-containing phosphatase SHP-2, phospholipase C-gamma, and Crk do not play a major role in mediating the PDGF-induced activation of p38.", "output": {"entities": {"gene": [{"text": "PDGF receptors", "start": 37, "end": 51}, {"text": "Src homology 2 domain-containing proteins", "start": 62, "end": 103}, {"text": "Src family kinases", "start": 114, "end": 132}, {"text": "phosphatidylinositol 3-kinase", "start": 134, "end": 163}, {"text": "GTPase-activating protein", "start": 169, "end": 194}, {"text": "Ras", "start": 198, "end": 201}, {"text": "Src homology 2 domain-containing phosphatase SHP-2", "start": 207, "end": 257}, {"text": "phospholipase C-gamma", "start": 259, "end": 280}, {"text": "Crk", "start": 286, "end": 289}, {"text": "PDGF", "start": 332, "end": 336}, {"text": "p38", "start": 359, "end": 362}]}}, "schema": []}
{"input": "Here we show that calpeptin inhibits tyrosine phosphatases, enhancing tyrosine phosphorylation particularly of paxillin.", "output": {"entities": {"gene": [{"text": "calpeptin", "start": 18, "end": 27}, {"text": "tyrosine phosphatases", "start": 37, "end": 58}, {"text": "paxillin", "start": 111, "end": 119}]}}, "schema": []}
{"input": "Three-dimensional structural studies using electron cryomicroscopy showed that the binding of one Fab (8H2/G5) does not affect the conformation of the capsid, and the efficiency of mRNA production is similar to that of the native subviral particle.", "output": {"entities": {"gene": [{"text": "Fab", "start": 98, "end": 101}]}}, "schema": []}
{"input": "Further, mutational analysis of NS5A assigned the SH3-binding region to a proline-rich motif that is highly conserved among HCV genotypes.", "output": {"entities": {"gene": [{"text": "NS5A", "start": 32, "end": 36}, {"text": "SH3-binding region", "start": 50, "end": 68}]}}, "schema": []}
{"input": "Taken together, these findings show that 16K hPRL inhibits the VEGF-induced Ras activation; this antagonism represents a novel and potentially important mechanism for the control of angiogenesis.", "output": {"entities": {"gene": [{"text": "16K hPRL", "start": 41, "end": 49}, {"text": "VEGF", "start": 63, "end": 67}, {"text": "Ras", "start": 76, "end": 79}]}}, "schema": []}
{"input": "Analysis of SRE oligonucleotide gel mobility shift assays with nuclear extracts from Sertoli cells demonstrated the presence of both the SRF and the ubiquitously expressed bHLH protein E12/E47.", "output": {"entities": {"gene": [{"text": "SRF", "start": 137, "end": 140}, {"text": "E12", "start": 185, "end": 188}, {"text": "E47", "start": 189, "end": 192}]}}, "schema": []}
{"input": "Baseline electrocorticography over the surface of the temporal lobe and depth electrode recordings in the amygdala and hippocampus were obtained, followed by 10 min of recording before and after the i. v. administration of both alfentanil 50 microg/kg and fentanyl 10 microg/kg.", "output": {"entities": {}}, "schema": []}
{"input": "We suggest that FlgN and FliT are substrate-specific flagellar chaperones that prevent oligomerization of the HAPs by binding to their helical domains before export.", "output": {"entities": {"gene": [{"text": "FlgN", "start": 16, "end": 20}, {"text": "FliT", "start": 25, "end": 29}, {"text": "HAPs", "start": 110, "end": 114}]}}, "schema": []}
{"input": "Post and core fabrication for divergent canals with a cast post and core and a prefabricated dowel.", "output": {"entities": {}}, "schema": []}
{"input": "Rep63A (513 amino acids [aa]), encoded by the largest ORF, displayed strong similarity (40% identity) to the replication proteins from plasmids pAMbeta1, pIP501, and pSM19035, indicating that the pAW63 replicon belongs to the pAMbeta1 family of gram-positive theta-replicating plasmids.", "output": {"entities": {"gene": [{"text": "Rep63A (513 amino acids [aa])", "start": 0, "end": 29}]}}, "schema": []}
{"input": "Here we report the cloning and characterization of Xenopus Pax-5 and Pax-8, two orthologues of the Pax-2/5/8 gene family.", "output": {"entities": {"gene": [{"text": "Xenopus Pax-5", "start": 51, "end": 64}, {"text": "Pax-8", "start": 69, "end": 74}, {"text": "Pax-2/5/8 gene family", "start": 99, "end": 120}]}}, "schema": []}
{"input": "Km values for ammonium, 2-oxoglutarate, NADH, glutamate and NAD + were 6. 5, 3. 5, 0. 06, 37. 1 and 0. 046 mM, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Interferon-alpha may exacerbate cryoblobulinemia-related ischemic manifestations: an adverse effect potentially related to its anti-angiogenic activity.", "output": {"entities": {"gene": [{"text": "Interferon-alpha", "start": 0, "end": 16}]}}, "schema": []}
{"input": "Interferon-alpha may exacerbate cryoblobulinemia-related ischemic manifestations: an adverse effect potentially related to its anti-angiogenic activity.", "output": {"entities": {"gene": [{"text": "Interferon-alpha", "start": 0, "end": 16}]}}, "schema": []}
{"input": "In addition, we demonstrate that the production of active recombinant telomerase requires a factor in rabbit reticulocyte lysate that promotes ribonucleoprotein assembly.", "output": {"entities": {"gene": [{"text": "active recombinant telomerase", "start": 51, "end": 80}]}}, "schema": []}
{"input": "Homozygous mutation in two children led to amputation of legs due to purpura fulminans.", "output": {"entities": {}}, "schema": []}
{"input": "According to pilot experiments which considered various durations of global no-flow ischemia ranging from 10 to 20 minutes, two durations were chosen for the present study: 20 minutes (group 20) in which ventricular fibrillation (VF) was the predominant form of arrhythmias, and 18 minutes (group 18) in which the prevalence of VF was markedly lower despite the small difference in the duration of ischemia.", "output": {"entities": {}}, "schema": []}
{"input": "An end-to-end pancreaticojejunostomy using a mechanical purse-string device.", "output": {"entities": {}}, "schema": []}
{"input": "Blood samples were obtained daily during this supplementation period and 5 d thereafter (d 11 to 15).", "output": {"entities": {}}, "schema": []}
{"input": "These results suggest that mitochondrial presequences interact with the mt-hsp70 during or after mitochondrial protein import.", "output": {"entities": {"gene": [{"text": "mt-hsp70", "start": 72, "end": 80}]}}, "schema": []}
{"input": "The 3' terminus of the genome can be folded into a tRNA-like secondary structure that has a valine anticodon; the tRNA-like structure lacks a pseudoknot in the aminoacyl stem, a feature common to both genera of tetraviruses.", "output": {"entities": {}}, "schema": []}
{"input": "Only one gene, fibronectin (FN), was highly overexpressed (> 60-fold) in LNCaP-r cells, consistent with previously reported overexpression of FN in prostate cancer.", "output": {"entities": {"gene": [{"text": "fibronectin", "start": 15, "end": 26}, {"text": "FN", "start": 28, "end": 30}, {"text": "FN", "start": 142, "end": 144}]}}, "schema": []}
{"input": "We also observed that cell surface CD4 (-) CD8 (-) CD3 (-) cells with rearranged TCR genes developed from Id3-transduced but not from control-transduced pre-T cells in an FTOC.", "output": {"entities": {"gene": [{"text": "CD4", "start": 35, "end": 38}, {"text": "CD8", "start": 43, "end": 46}, {"text": "CD3", "start": 51, "end": 54}, {"text": "rearranged TCR genes", "start": 70, "end": 90}, {"text": "Id3", "start": 106, "end": 109}]}}, "schema": []}
{"input": "As determined in a modified yeast two-hybrid system, mIRS3 bound strongly to the p85 subunit of phosphatidylinositol 3-kinase.", "output": {"entities": {"gene": [{"text": "mIRS3", "start": 53, "end": 58}, {"text": "p85 subunit", "start": 81, "end": 92}, {"text": "phosphatidylinositol 3-kinase", "start": 96, "end": 125}]}}, "schema": []}
{"input": "Insulin stimulation promoted the association of mIRS3 with p85, SHP2, Nck, and Shc.", "output": {"entities": {"gene": [{"text": "Insulin", "start": 0, "end": 7}, {"text": "mIRS3", "start": 48, "end": 53}, {"text": "p85", "start": 59, "end": 62}, {"text": "SHP2", "start": 64, "end": 68}, {"text": "Nck", "start": 70, "end": 73}, {"text": "Shc", "start": 79, "end": 82}]}}, "schema": []}
{"input": "The mRNA expression of RFX1, RFX2, and RFX3 was detected ubiquitously, but in transient-transfection assays, multimerized RFX binding sites in front of a basal promoter efficiently functioned in a tissue-and lineage-specific manner.", "output": {"entities": {"gene": [{"text": "RFX1", "start": 23, "end": 27}, {"text": "RFX2", "start": 29, "end": 33}, {"text": "RFX3", "start": 39, "end": 43}, {"text": "multimerized RFX binding sites", "start": 109, "end": 139}]}}, "schema": []}
{"input": "In the case of the unspliceable intron, repression of luciferase expression likely involved two AUF1-binding sequences, since luciferase expression was increased by deletion of these sites.", "output": {"entities": {"gene": [{"text": "luciferase", "start": 54, "end": 64}, {"text": "AUF1-binding sequences", "start": 96, "end": 118}, {"text": "luciferase", "start": 126, "end": 136}]}}, "schema": []}
{"input": "Thus, VDR acts selectively on the two components required for activation of this promoter/enhancer: it competes with NFAT1 for binding to the composite site, positioning itself adjacent to Jun-Fos on the DNA.", "output": {"entities": {"gene": [{"text": "VDR", "start": 6, "end": 9}, {"text": "NFAT1", "start": 117, "end": 122}, {"text": "Jun", "start": 189, "end": 192}, {"text": "Fos", "start": 193, "end": 196}]}}, "schema": []}
{"input": "Two evolutionarily conserved kinases, the cyclin B (Clb)/cyclin-dependent kinase (Cdk/Cdc28p) and Cdc7p along with its interacting factor Dbf4p, are required late in G1 to initiate DNA replication.", "output": {"entities": {"gene": [{"text": "cyclin B", "start": 42, "end": 50}, {"text": "Clb", "start": 52, "end": 55}, {"text": "cyclin-dependent kinase", "start": 57, "end": 80}, {"text": "Cdk", "start": 82, "end": 85}, {"text": "Cdc28p", "start": 86, "end": 92}, {"text": "Cdc7p", "start": 98, "end": 103}, {"text": "Dbf4p", "start": 138, "end": 143}]}}, "schema": []}
{"input": "The RanQ69L preincubation leads to accumulation of CRM1 at the cytoplasmic periphery of the nuclear pore complex (NPC) in association with the p62 complex and Can/Nup214.", "output": {"entities": {"gene": [{"text": "RanQ69L", "start": 4, "end": 11}, {"text": "CRM1", "start": 51, "end": 55}, {"text": "p62 complex", "start": 143, "end": 154}, {"text": "Can", "start": 159, "end": 162}, {"text": "Nup214", "start": 163, "end": 169}]}}, "schema": []}
{"input": "All of the elements exhibited a uniform structure.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast, the deduced amino acid sequence of a second family (ART5) of transferases, cloned from murine lymphoma cells and expressed in high abundance in testis, displays a hydrophobic amino terminus, consistent with a signal sequence, but lacks a hydrophobic signal sequence at its carboxyl terminus, suggesting that the protein is destined for export.", "output": {"entities": {"gene": [{"text": "ART5", "start": 65, "end": 69}]}}, "schema": []}
{"input": "RESULTS: Each year, on average 39% of cases seen in Sardinia are notified; 646 (40%) of the 1591 patients notified during the study period were never seen by regional medical centres.", "output": {"entities": {}}, "schema": []}
{"input": "This dimer interface is likely important for increasing the DNA-binding specificity and affinity of the trimeric form of HSF, as well as for increasing cooperativity between adjacent trimers.", "output": {"entities": {"gene": [{"text": "HSF", "start": 121, "end": 124}]}}, "schema": []}
{"input": "Additionally, deletion analysis of the UCP2 promoter-PLAP constructs indicated that the minimal region exhibiting the promoter activity was located between nt-33 and + 100, and that a strong enhancer was present within 601 bp of the 5'-promoter region.", "output": {"entities": {"gene": [{"text": "UCP2", "start": 39, "end": 43}, {"text": "PLAP", "start": 53, "end": 57}]}}, "schema": []}
{"input": "The hTERT gene encompasses more than 37kb and consists of 16 exons.", "output": {"entities": {"gene": [{"text": "hTERT gene", "start": 4, "end": 14}]}}, "schema": []}
{"input": "Both betaAPP mRNA and Abeta levels are increased in trisomy 21.", "output": {"entities": {"gene": [{"text": "betaAPP mRNA", "start": 5, "end": 17}, {"text": "Abeta", "start": 22, "end": 27}]}}, "schema": []}
{"input": "In reperfusion B, only the diabetic group demonstrated a significant increase in IL-8 concentrations at 1 and 15 min compared to nondiabetics.", "output": {"entities": {"gene": [{"text": "IL-8", "start": 81, "end": 85}]}}, "schema": []}
{"input": "This repression was reversed agonists of either receptor demonstrating a functional interaction between NCoR and PPARalpha. RXRalpha heterodimeric complexes in mammalian cells.", "output": {"entities": {"gene": [{"text": "NCoR", "start": 104, "end": 108}, {"text": "PPARalpha", "start": 113, "end": 122}, {"text": "RXRalpha", "start": 124, "end": 132}]}}, "schema": []}
{"input": "Spc42p also was identified as a component of a cytoplasmic SPB subcomplex containing Spc94p/Nud1p, Cnm67p, and Spc42p.", "output": {"entities": {"gene": [{"text": "Spc42p", "start": 0, "end": 6}, {"text": "Spc94p", "start": 85, "end": 91}, {"text": "Nud1p", "start": 92, "end": 97}, {"text": "Cnm67p", "start": 99, "end": 105}, {"text": "Spc42p", "start": 111, "end": 117}]}}, "schema": []}
{"input": "The average coefficients of correlation were 0. 9998 and 0. 9993 for the QMF and the QIT system, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "The 5-year OS for stage IIIB was 30. 9%, compared to 7. 8% for stage IV.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, heparin lyase treatment of extracts of cells expressing recombinant YD-repeat protein releases this protein from high molecular mass aggregates.", "output": {"entities": {"gene": [{"text": "heparin lyase", "start": 13, "end": 26}, {"text": "recombinant YD-repeat protein", "start": 69, "end": 98}]}}, "schema": []}
{"input": "CDK4 kinase activities were unaffected, as were the levels of the CDK inhibitor p21Cip1 present in cyclin E immunocomplexes.", "output": {"entities": {"gene": [{"text": "CDK4 kinase", "start": 0, "end": 11}, {"text": "CDK", "start": 66, "end": 69}, {"text": "p21Cip1", "start": 80, "end": 87}, {"text": "cyclin E immunocomplexes", "start": 99, "end": 123}]}}, "schema": []}
{"input": "The recombinant purified protein expressed in the baculovirus system had an approximate molecular size 20 kDa with amino-terminal sequence of AVQGP.", "output": {"entities": {}}, "schema": []}
{"input": "Induction of the urokinase promoter by HGF/SF via the Met receptor was blocked by co-expression of a dominant-negative Grb2 and Sos1 expression construct.", "output": {"entities": {"gene": [{"text": "urokinase promoter", "start": 17, "end": 35}, {"text": "HGF", "start": 39, "end": 42}, {"text": "SF", "start": 43, "end": 45}, {"text": "Met receptor", "start": 54, "end": 66}, {"text": "Grb2", "start": 119, "end": 123}, {"text": "Sos1", "start": 128, "end": 132}]}}, "schema": []}
{"input": "Serine phosphorylation of STAT3 was only apparent after somatostatin treatment and was abolished by pertussis toxin or PD 98059, together with the associated increases in proliferation.", "output": {"entities": {"gene": [{"text": "STAT3", "start": 26, "end": 31}, {"text": "somatostatin", "start": 56, "end": 68}, {"text": "pertussis toxin", "start": 100, "end": 115}]}}, "schema": []}
{"input": "Nevertheless, we demonstrate that the entire three-component yeast capping apparatus, consisting of RNA 5'-triphosphatase (Cet1p), RNA guanylyltransferase (Ceg1p), and Abd1p could be replaced in vivo by the two-component mammalian apparatus consisting of a bifunctional triphosphatase-guanylyltransferase Mce1p and the methyltransferase Hcm1 (121-476) p.", "output": {"entities": {"gene": [{"text": "RNA 5'-triphosphatase", "start": 100, "end": 121}, {"text": "Cet1p", "start": 123, "end": 128}, {"text": "RNA guanylyltransferase", "start": 131, "end": 154}, {"text": "Ceg1p", "start": 156, "end": 161}, {"text": "Abd1p", "start": 168, "end": 173}, {"text": "triphosphatase-guanylyltransferase Mce1p", "start": 270, "end": 310}, {"text": "methyltransferase Hcm1 (121-476) p", "start": 319, "end": 353}]}}, "schema": []}
{"input": "The IC50 values for rat and dog urinary bladder were 3. 9 x 10 (-6) M and 3. 8 x 10 (-6) M, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Although it has two potential binding sites, the purified MerR homodimer binds only one Hg (II) ion, employing Cys82 from one monomer and Cys117 and Cys126 from the other.", "output": {"entities": {"gene": [{"text": "MerR homodimer", "start": 58, "end": 72}]}}, "schema": []}
{"input": "The influence of Epstein-Barr virus seropositivity on the efficacy of intravenous immune globulin in children with immune thrombocytopenic purpura.", "output": {"entities": {"gene": [{"text": "immune globulin", "start": 82, "end": 97}]}}, "schema": []}
{"input": "The results of the lab and field tests yielded high levels of infestation in larvae with values ranging from 90 to 100% and from 85 to 95%, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Amisulpride 400 mg had several adverse effects on psychomotor and, although less severe, on cognitive performance on the fifth day only.", "output": {"entities": {}}, "schema": []}
{"input": "MutY is an adenine-DNA glycosylase with specificity for mismatches involving 8-oxoguanine (oG. A) or guanine (G. A).", "output": {"entities": {"gene": [{"text": "MutY", "start": 0, "end": 4}, {"text": "adenine-DNA glycosylase", "start": 11, "end": 34}]}}, "schema": []}
{"input": "The kinetics of kinase activity within these complexes compared to CheA alone indicate approximately a 50% decrease in the KM for ATP and a 100-fold increase in the Vmax.", "output": {"entities": {"gene": [{"text": "CheA", "start": 67, "end": 71}]}}, "schema": []}
{"input": "Latexin, a carboxypeptidase A inhibitor, is expressed in a cell type-specific manner in both central and peripheral nervous systems in the rat.", "output": {"entities": {"gene": [{"text": "Latexin", "start": 0, "end": 7}, {"text": "carboxypeptidase A", "start": 11, "end": 29}]}}, "schema": []}
{"input": "Regression analyses identified 7 risk and 7 protective factors with minimal overlap.", "output": {"entities": {}}, "schema": []}
{"input": "During 1985, 1990, and 1995, respectively, 11. 7, 11. 3, and 11. 4 infants per 100, 000 live births had a diagnosis of HSV (P =. 98).", "output": {"entities": {}}, "schema": []}
{"input": "Subsets of patients were performed according to the severity of trauma (ISS < 9; 9-17; 18-31; > 32), based on the different injury pattern, and survivors versus nonsurvivors as well.", "output": {"entities": {}}, "schema": []}
{"input": "The median age was 33 years (range 17-56 years).", "output": {"entities": {}}, "schema": []}
{"input": "Developmental follow-up at age 2 years was performed.", "output": {"entities": {}}, "schema": []}
{"input": "In the whole group of infected children, an age-specific z score <-2 for weight and for FFM was significantly associated with an increased risk of death [relative risk (95% CI) = 11. 4 (3. 1, 41. 0) and 5. 1 (1. 5, 18. 2), respectively]; when only children with more severe disease were considered, only z score for weight was significantly associated with an increased risk [4. 6 (1. 4, 14. 9)].", "output": {"entities": {}}, "schema": []}
{"input": "In addition, these cells contained one, two, or multiple nuclei indicative of a G2/M delay in nuclear division and also a defect in cytokinesis and/or cell separation.", "output": {"entities": {}}, "schema": []}
{"input": "DAF16 is known to be a component of a signaling pathway that has been partially dissected genetically and includes homologues of the insulin/IGF-1 receptor, PtdIns 3-kinase and PKB.", "output": {"entities": {"gene": [{"text": "DAF16", "start": 0, "end": 5}, {"text": "insulin", "start": 133, "end": 140}, {"text": "IGF-1 receptor", "start": 141, "end": 155}, {"text": "PtdIns 3-kinase", "start": 157, "end": 172}, {"text": "PKB", "start": 177, "end": 180}]}}, "schema": []}
{"input": "However, neu differentiation factor-induced heterodimers of ErbB2 and ErbB4 activated Stat5.", "output": {"entities": {"gene": [{"text": "neu", "start": 9, "end": 12}, {"text": "ErbB2", "start": 60, "end": 65}, {"text": "ErbB4", "start": 70, "end": 75}, {"text": "Stat5", "start": 86, "end": 91}]}}, "schema": []}
{"input": "Although linker regions in transcription factors are known to modulate DNA binding specificity, our studies suggest that the human HSF1 linker plays no role in determining HSF1 binding preferences in vivo but is a critical determinant in regulating the HSF1 monomer-trimer equilibrium.", "output": {"entities": {"gene": [{"text": "human HSF1", "start": 125, "end": 135}, {"text": "HSF1", "start": 172, "end": 176}, {"text": "HSF1 monomer-trimer", "start": 253, "end": 272}]}}, "schema": []}
{"input": "Modulation of human heat shock factor trimerization by the linker domain.", "output": {"entities": {"gene": [{"text": "human heat shock factor", "start": 14, "end": 37}]}}, "schema": []}
{"input": "Both functional analyses in undifferentiated and differentiated F9 cells and characterization of DNA-protein complexes in vitro have identified the sequence motifs GTGACT (C), ATTGT, and GATA as the key transcription factor binding sites.", "output": {"entities": {}}, "schema": []}
{"input": "These results suggest that the phenotype of XLP may result from perturbed signaling not only through SLAM, but also other cell surface molecules that utilize SAP as a signaling adaptor protein.", "output": {"entities": {"gene": [{"text": "SLAM", "start": 101, "end": 105}, {"text": "SAP", "start": 158, "end": 161}]}}, "schema": []}
{"input": "We also localized the Fra-2 phosphorylation sites by MAPK to three threonine and three serine residues in the COOH-terminal region by means of site-directed mutagenesis and showed that the threonine residues were more susceptible to MAPK.", "output": {"entities": {"gene": [{"text": "Fra-2 phosphorylation sites", "start": 22, "end": 49}, {"text": "MAPK", "start": 53, "end": 57}, {"text": "MAPK", "start": 233, "end": 237}]}}, "schema": []}
{"input": "Nevertheless, they are functionally distinct in that FcalphaRI binds human IgA (hIgA) but not bovine IgG2 (bIgG2), whereas bFcgamma2R binds bIgG2 but not hIgA.", "output": {"entities": {"gene": [{"text": "FcalphaRI", "start": 53, "end": 62}, {"text": "human IgA", "start": 69, "end": 78}, {"text": "hIgA", "start": 80, "end": 84}, {"text": "bovine IgG2", "start": 94, "end": 105}, {"text": "bIgG2", "start": 107, "end": 112}, {"text": "bFcgamma2R", "start": 123, "end": 133}, {"text": "bIgG2", "start": 140, "end": 145}, {"text": "hIgA", "start": 154, "end": 158}]}}, "schema": []}
{"input": "Vac1p was found to bind the Sec1p homologue Vps45p.", "output": {"entities": {"gene": [{"text": "Vac1p", "start": 0, "end": 5}, {"text": "Sec1p homologue Vps45p", "start": 28, "end": 50}]}}, "schema": []}
{"input": "To identify these sites, Cdk2-phosphorylated MARCKS was digested with lysyl endoprotease and analysed by electrospray MS.", "output": {"entities": {"gene": [{"text": "Cdk2", "start": 25, "end": 29}, {"text": "MARCKS", "start": 45, "end": 51}, {"text": "lysyl endoprotease", "start": 70, "end": 88}]}}, "schema": []}
{"input": "The yeast LPD1 gene encoding lipoamide dehydrogenase is subject to the general control of amino acid biosynthesis mediated by the GCN4 transcription factor.", "output": {"entities": {"gene": [{"text": "yeast LPD1 gene", "start": 4, "end": 19}, {"text": "lipoamide dehydrogenase", "start": 29, "end": 52}, {"text": "GCN4 transcription factor", "start": 130, "end": 155}]}}, "schema": []}
{"input": "However, the serum TNF-a concentration decreased significantly in patients receiving pentoxifylline (basal 623 +/-366 pg/ml; 6th month 562 +/-358 pg/ml, p < 0. 01), but not in the control group.", "output": {"entities": {"gene": [{"text": "serum TNF-a", "start": 13, "end": 24}]}}, "schema": []}
{"input": "In addition, we show that the expression of individual members of one subfamily of KRAB zinc finger genes is restricted to specific hematopoietic cell lineages.", "output": {"entities": {"gene": [{"text": "KRAB zinc finger genes", "start": 83, "end": 105}]}}, "schema": []}
{"input": "Employing fluorescence spectroscopy and circular dichroism, we showed that the binding of Ca2 + to ALG-2 induced significant conformational changes in both the N-terminal and C-terminal domains of the protein.", "output": {"entities": {"gene": [{"text": "ALG-2", "start": 99, "end": 104}]}}, "schema": []}
{"input": "They also occur in similar locations in the promoters of several other ribosomal protein genes.", "output": {"entities": {"gene": [{"text": "ribosomal protein genes", "start": 71, "end": 94}]}}, "schema": []}
{"input": "RESULTS: Transpulmonary passage of contrast occurred in sufficient amounts to enhance the intensity of the Doppler signal significantly, but the duration of this effect was short.", "output": {"entities": {}}, "schema": []}
{"input": "In this paper, such lesions in two cases were evaluated by ultrasonography.", "output": {"entities": {}}, "schema": []}
{"input": "These regions contain inverted E-box palindromic or direct repeat motifs and bind SREBP-1 with different affinities.", "output": {"entities": {"gene": [{"text": "SREBP-1", "start": 82, "end": 89}]}}, "schema": []}
{"input": "To address these questions, a recombinant FRAP/mTOR protein and a FRAP/mTOR immunoprecipitate were utilized in in vitro kinase assays to phosphorylate 4E-BP1.", "output": {"entities": {"gene": [{"text": "FRAP", "start": 42, "end": 46}, {"text": "mTOR", "start": 47, "end": 51}, {"text": "FRAP", "start": 66, "end": 70}, {"text": "mTOR", "start": 71, "end": 75}, {"text": "4E-BP1", "start": 151, "end": 157}]}}, "schema": []}
{"input": "The coexpression of full-length expression constructs for both DBP and hepatic leukemia factor resulted in a dramatic increase in activation mediated by the GAL4-DBP fusion proteins, suggesting the involvement of a regulated coactivator in this process.", "output": {"entities": {"gene": [{"text": "DBP", "start": 63, "end": 66}, {"text": "hepatic leukemia factor", "start": 71, "end": 94}, {"text": "GAL4", "start": 157, "end": 161}, {"text": "DBP", "start": 162, "end": 165}]}}, "schema": []}
{"input": "Cp is normally the main promoter for EBNA mRNA initiation, so it appears that EBNA3C contributes to a negative autoregulatory control loop.", "output": {"entities": {"gene": [{"text": "Cp", "start": 0, "end": 2}, {"text": "EBNA mRNA", "start": 37, "end": 46}, {"text": "EBNA3C", "start": 78, "end": 84}]}}, "schema": []}
{"input": "These indications of deregulated signalling in the absence of tyrosine 118 were substantiated by sustained activation of STAT3.", "output": {"entities": {"gene": [{"text": "STAT3", "start": 121, "end": 126}]}}, "schema": []}
{"input": "With exon trapping, we could isolate five potential exons from the YAC 946E12 that spans the region, four of which could be placed in the contig in the vicinity of the breakpoints.", "output": {"entities": {}}, "schema": []}
{"input": "Campomelic dysplasia translocation breakpoints are scattered over 1 Mb proximal to SOX9: evidence for an extended control region.", "output": {"entities": {"gene": [{"text": "SOX9", "start": 83, "end": 87}]}}, "schema": []}
{"input": "The most common characteristics of VRE patients were recent prior vancomycin use, recent prior susceptible enterococcal infection, coinfection with other microbial pathogens, and concurrent fungal infection.", "output": {"entities": {}}, "schema": []}
{"input": "A coiled-coil domain, conserved within each encoded protein, serves as a potential interaction motif for FLI LRR.", "output": {"entities": {"gene": [{"text": "FLI LRR", "start": 105, "end": 112}]}}, "schema": []}
{"input": "Binding affinities of these recombinant phages as determined by the retention of these phages by a His-tag immobilized gp17 column, and by co-immunoprecipitation with purified terminase supported the specific nature of the portal protein and terminase interaction sites.", "output": {"entities": {"gene": [{"text": "gp17", "start": 119, "end": 123}, {"text": "terminase", "start": 176, "end": 185}, {"text": "portal protein", "start": 223, "end": 237}, {"text": "terminase interaction sites", "start": 242, "end": 269}]}}, "schema": []}
{"input": "Although the terminase apparently interacts with this gp20 portal peptide, polyclonal antibody against the portal peptide appears unable to access it in the native structure, suggesting intimate association of gp20 and gp17 possibly internalizes terminase regions within the portal in the packasome complex.", "output": {"entities": {"gene": [{"text": "terminase", "start": 13, "end": 22}, {"text": "gp20 portal peptide", "start": 54, "end": 73}, {"text": "gp20", "start": 210, "end": 214}, {"text": "gp17", "start": 219, "end": 223}, {"text": "terminase regions", "start": 246, "end": 263}]}}, "schema": []}
{"input": "cDNA and structural organization of the gene Pole1 for the mouse DNA polymerase epsilon catalytic subunit.", "output": {"entities": {"gene": [{"text": "gene Pole1", "start": 40, "end": 50}, {"text": "mouse DNA polymerase epsilon catalytic subunit", "start": 59, "end": 105}]}}, "schema": []}
{"input": "A liquid chromatographic method is described for analysis of beta-carotene in medical food.", "output": {"entities": {}}, "schema": []}
{"input": "The FCMS conditions were as follows: 2 kW maximum electrical power consumption, 800 V maximum capacitor voltage, 720 microseconds pulsewidth (180 microseconds rise time), and 5-30 Hz frequency.", "output": {"entities": {}}, "schema": []}
{"input": "Severe hemolysis resulted in statistically significant changes in the mean values of the above analytes in addition to the following increases: alanine aminotransferase, calcium, and serum globulins (P < 0. 001) and albumin and total protein (P < 0. 01).", "output": {"entities": {"gene": [{"text": "alanine aminotransferase", "start": 144, "end": 168}, {"text": "serum globulins", "start": 183, "end": 198}, {"text": "albumin", "start": 216, "end": 223}]}}, "schema": []}
{"input": "Optimal monitoring of ODA remains undefined.", "output": {"entities": {}}, "schema": []}
{"input": "The exon: intron structure of chicken IL8 corresponds almost exactly to that of human IL8 and differs from those of other known mammalian CXC chemokine genes.", "output": {"entities": {"gene": [{"text": "chicken IL8", "start": 30, "end": 41}, {"text": "human IL8", "start": 80, "end": 89}, {"text": "mammalian CXC chemokine genes", "start": 128, "end": 157}]}}, "schema": []}
{"input": "The Aa-Pri2 gene, specifically expressed during basidiocarp differentiation of the mushroom Agrocybe aegerita, was cloned.", "output": {"entities": {"gene": [{"text": "Aa-Pri2 gene", "start": 4, "end": 16}]}}, "schema": []}
{"input": "The main causes of liver disease in the patients with HCC were hepatitis C virus (HCV) (77%), alcohol abuse (73%), and the combination of HCV and alcohol abuse (50%).", "output": {"entities": {}}, "schema": []}
{"input": "Three new aromatase inhibitors have recently completed phase III evaluation as treatment of metastatic breast cancer in post-menopausal women whose disease has progressed despite tamoxifen therapy: anastrozole (ARIMIDEX, Zeneca), letrozole (FEMARA, Novartis) and vorozole (RIVIZOR, Janssen).", "output": {"entities": {"gene": [{"text": "aromatase", "start": 10, "end": 19}]}}, "schema": []}
{"input": "Of those injuries, 143 cases were snowboard related and 158 cases were ski related.", "output": {"entities": {}}, "schema": []}
{"input": "The femoral artery/vein and the soleus and gastrocnemius muscles were examined in healthy human male volunteers.", "output": {"entities": {}}, "schema": []}
{"input": "SRFDelta5 acts as a naturally occurring dominant negative regulatory mutant that blocks SRF-dependent skeletal alpha-actin, cardiac alpha-actin, smooth alpha-actin, SM22alpha, and SRF promoter-luciferase reporter activities.", "output": {"entities": {"gene": [{"text": "SRFDelta5", "start": 0, "end": 9}, {"text": "SRF", "start": 88, "end": 91}, {"text": "skeletal alpha-actin", "start": 102, "end": 122}, {"text": "cardiac alpha-actin", "start": 124, "end": 143}, {"text": "smooth alpha-actin", "start": 145, "end": 163}, {"text": "SM22alpha", "start": 165, "end": 174}, {"text": "SRF", "start": 180, "end": 183}, {"text": "luciferase", "start": 193, "end": 203}]}}, "schema": []}
{"input": "In serum-free media, p50E4F accelerated E1A-induced apoptosis.", "output": {"entities": {"gene": [{"text": "p50E4F", "start": 21, "end": 27}, {"text": "E1A", "start": 40, "end": 43}]}}, "schema": []}
{"input": "Progression after first-line chemotherapy was associated with significantly worse survival for patients with metastasis.", "output": {"entities": {}}, "schema": []}
{"input": "Mutations within human UTR1 modulate NRF-1 expression by interfering with mRNA translational efficiency in transfected cells and in an in vitro translation system.", "output": {"entities": {"gene": [{"text": "NRF-1", "start": 37, "end": 42}]}}, "schema": []}
{"input": "As is deduced from the nucleotide sequence of the cDNA, CBS-1 contains an open reading frame consisting of 182 amino acids, with a molecular weight of 19. 5kDa.", "output": {"entities": {"gene": [{"text": "CBS-1", "start": 56, "end": 61}]}}, "schema": []}
{"input": "Corticostriatal and corticosubthalamic input zones from the presupplementary motor area in the macaque monkey: comparison with the input zones from the supplementary motor area.", "output": {"entities": {}}, "schema": []}
{"input": "Basic fibroblast growth factor (bFGF) has been shown to induce angiogenesis in various animal models, but the methods of administration used experimentally are not clinically feasible.", "output": {"entities": {"gene": [{"text": "Basic fibroblast growth factor", "start": 0, "end": 30}, {"text": "bFGF", "start": 32, "end": 36}]}}, "schema": []}
{"input": "Both filters equally contributed to elevation of iliac venous pressure (median, 9. 3 and 7. 2 mm Hg [n = 9] with the spring filter and RF02 filter, respectively).", "output": {"entities": {}}, "schema": []}
{"input": "12 healthy women (age 18-38 years) were examined using the 2-hour' s method of passive leg rising (PLR) in follicular (FP) and luteal (LP) phases of normal ovulatory cycle.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, sgRNA2 has the 3' TE in its 5' UTR.", "output": {"entities": {"gene": [{"text": "sgRNA2", "start": 6, "end": 12}]}}, "schema": []}
{"input": "These single mutational defects in the eRF1-eRF3 interaction became evident when either truncated protein eRF3C or C-terminally altered eRF1 proteins were used for the authentic protein, providing further support for the presence of a C-terminal interaction.", "output": {"entities": {"gene": [{"text": "eRF1", "start": 39, "end": 43}, {"text": "eRF3", "start": 44, "end": 48}, {"text": "eRF3C", "start": 106, "end": 111}, {"text": "eRF1", "start": 136, "end": 140}]}}, "schema": []}
{"input": "Removal of each of three contiguous segments from the N-terminal half specifically inhibits the formation of 5. 8Ss rRNA, whereas deleting part of the C-terminal region of the protein only blocks the production of 18S rRNA.", "output": {"entities": {"gene": [{"text": "5. 8Ss rRNA", "start": 109, "end": 120}, {"text": "18S rRNA", "start": 214, "end": 222}]}}, "schema": []}
{"input": "Ras is not associated with the tegument.", "output": {"entities": {"gene": [{"text": "Ras", "start": 0, "end": 3}]}}, "schema": []}
{"input": "Green fluorescent protein-tagged UNC-49B and UNC-49C subunits are coexpressed in muscle cells and are colocalized to synaptic regions.", "output": {"entities": {"gene": [{"text": "UNC-49B", "start": 33, "end": 40}, {"text": "UNC-49C subunits", "start": 45, "end": 61}]}}, "schema": []}
{"input": "We show that a protein, UBC9, interacts specifically with TEL in vitro and in vivo.", "output": {"entities": {"gene": [{"text": "UBC9", "start": 24, "end": 28}, {"text": "TEL", "start": 58, "end": 61}]}}, "schema": []}
{"input": "Molecules of NH3 are capable of emitting stimulated radiation (MASER).", "output": {"entities": {}}, "schema": []}
{"input": "The major findings of our studies are as follows: 1) There are no detectable signals around GDF-9-deficient follicles for several theca cell layer markers [i. e.", "output": {"entities": {"gene": [{"text": "GDF-9", "start": 92, "end": 97}]}}, "schema": []}
{"input": "Interestingly, highly charged residues were abundantly possessed in the carboxy-terminal part of the MDV2 UL10 protein.", "output": {"entities": {"gene": [{"text": "MDV2 UL10 protein", "start": 101, "end": 118}]}}, "schema": []}
{"input": "Identification and structure of the Marek' s disease virus serotype 2 glycoprotein M gene: comparison with glycoprotein M genes of Herpesviridae family.", "output": {"entities": {"gene": [{"text": "Marek' s disease virus serotype 2 glycoprotein M gene", "start": 36, "end": 89}, {"text": "glycoprotein M genes", "start": 107, "end": 127}]}}, "schema": []}
{"input": "OBJECTIVE: To perform a cost-effectiveness analysis (CEA) between a standard antiemetic regimen-chlorpromazine + dexamethasone (CPM-DEX)-and a 5-HT3 receptor antagonist-tropisetron (TROP)--in the control of acute emesis induced by highly emetogenic chemotherapy in children, considering two analytic perspectives: hospital and patients.", "output": {"entities": {"gene": [{"text": "5-HT3 receptor", "start": 143, "end": 157}]}}, "schema": []}
{"input": "Baseline data were obtained from 10 adults.", "output": {"entities": {}}, "schema": []}
{"input": "A comparison of the nucleotide and deduced amino acid sequences of the core regions of the RNA-dependent RNA polymerase domains found in these three dsRNAs suggested that these dsRNAs probably evolved independently within each host plant from a common ancestor.", "output": {"entities": {"gene": [{"text": "RNA-dependent RNA polymerase domains", "start": 91, "end": 127}]}}, "schema": []}
{"input": "Consistent with this possibility, a non-MBD region of Bin1 was sufficient to recruit a repression function to DNA that was unrelated to histone deacetylase.", "output": {"entities": {"gene": [{"text": "MBD", "start": 40, "end": 43}, {"text": "Bin1", "start": 54, "end": 58}, {"text": "histone deacetylase", "start": 136, "end": 155}]}}, "schema": []}
{"input": "Forty-eight sequences, 30 not previously identified as IR-responsive, were significantly regulated by IR.", "output": {"entities": {}}, "schema": []}
{"input": "A recently described protein, metaxin 1, serves as a component of a preprotein import complex in the outer membrane of the mammalian mitochondrion.", "output": {"entities": {"gene": [{"text": "metaxin 1", "start": 30, "end": 39}]}}, "schema": []}
{"input": "Molecular cloning of rat SH2-containing inositol phosphatase 2 (SHIP2) and its role in the regulation of insulin signaling.", "output": {"entities": {"gene": [{"text": "rat SH2-containing inositol phosphatase 2", "start": 21, "end": 62}, {"text": "SHIP2", "start": 64, "end": 69}, {"text": "insulin", "start": 105, "end": 112}]}}, "schema": []}
{"input": "Slp1 represses transcription via this binding site in yeast cells, consistent with its role as a direct repressor of ftz stripes in interstripe regions during late stages of embryogenesis.", "output": {"entities": {"gene": [{"text": "Slp1", "start": 0, "end": 4}, {"text": "ftz", "start": 117, "end": 120}]}}, "schema": []}
{"input": "The results of these studies support a model in which VirB4 dimers or homomultimers contribute structural information for the assembly of a transenvelope channel competent for bidirectional DNA transfer, whereas an ATP-dependent activity is required for configuring this channel as a dedicated export machine.", "output": {"entities": {"gene": [{"text": "VirB4 dimers", "start": 54, "end": 66}]}}, "schema": []}
{"input": "The penicillin binding proteins (PBPs) synthesize and remodel peptidoglycan, the structural component of the bacterial cell wall.", "output": {"entities": {"gene": [{"text": "penicillin binding proteins", "start": 4, "end": 31}, {"text": "PBPs", "start": 33, "end": 37}]}}, "schema": []}
{"input": "TCR alpha (TCRA) expression was examined in RNA samples from PBMC and isolated populations of CD4 +, CD8 +, and DN T cells from 15 healthy individuals.", "output": {"entities": {"gene": [{"text": "TCR alpha", "start": 0, "end": 9}, {"text": "TCRA", "start": 11, "end": 15}, {"text": "CD4 +", "start": 94, "end": 99}, {"text": "CD8 +", "start": 101, "end": 106}]}}, "schema": []}
{"input": "Similar results were obtained with xylitol, an activator of the pentose phosphate pathway.", "output": {"entities": {}}, "schema": []}
{"input": "D3S1261 is physically located at or near the MITF locus, while D3S2465 and D3S1766 are flanking the locus at about 17. 5 cM genetic distance each side.", "output": {"entities": {"gene": [{"text": "D3S1261", "start": 0, "end": 7}, {"text": "MITF locus", "start": 45, "end": 55}, {"text": "D3S2465", "start": 63, "end": 70}, {"text": "D3S1766", "start": 75, "end": 82}]}}, "schema": []}
{"input": "The percentages of recovery decreased with storage time, although the addition of dispersant (Tris-Tween 80) before storage appeared to partially prevent adhesion.", "output": {"entities": {}}, "schema": []}
{"input": "Point mutations of the site that suppressed Pit-1 binding in vitro restored full tiGH promoter activity.", "output": {"entities": {"gene": [{"text": "Pit-1", "start": 44, "end": 49}, {"text": "tiGH promoter", "start": 81, "end": 94}]}}, "schema": []}
{"input": "A human Raf-responsive zinc-finger protein that binds to divergent sequences.", "output": {"entities": {"gene": [{"text": "human Raf-responsive zinc-finger protein", "start": 2, "end": 42}]}}, "schema": []}
{"input": "We are reporting an autopsy case of so-called \" acute multiple sclerosis \" that was difficult to differentiate from a brain tumor on MRI findings.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, MOM-4 and TAK1 bind related proteins that promote their kinase activities.", "output": {"entities": {"gene": [{"text": "MOM-4", "start": 13, "end": 18}, {"text": "TAK1", "start": 23, "end": 27}]}}, "schema": []}
{"input": "BACKGROUND: The MAZE-III is the surgical treatment of choice for medically refractory atrial fibrillation.", "output": {"entities": {}}, "schema": []}
{"input": "Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1.", "output": {"entities": {"gene": [{"text": "Gab2", "start": 0, "end": 4}, {"text": "pleckstrin", "start": 12, "end": 22}, {"text": "ERK kinase", "start": 99, "end": 109}, {"text": "Elk-1", "start": 113, "end": 118}]}}, "schema": []}
{"input": "The presence of cutaneous xanthomas with normal serum lipid levels is due to the antibetalipoproteic activity of the monoclonal immunoglobulin.", "output": {"entities": {"gene": [{"text": "monoclonal immunoglobulin", "start": 117, "end": 142}]}}, "schema": []}
{"input": "In an attempt to reduce the incidence of NSAID-induced gastrointestinal lesions, the following approaches have been proposed: (i) use of the prostaglandin analogue misoprostol, which is an antiulcer drug which has been proven to be as effective in the prevention of NSAID-induced gastric and duodenal ulcers as in the reduction of serious upper gastrointestinal complications; (ii) histamine H2 receptor antagonists (H2 antagonists), e. g. ranitidine, cimetidine and famotidine, which are useful in the prevention of NSAID-induced duodenal ulcers during long term treatment, but not in the prevention of NSAID-induced gastric ulcers; (iii) proton pump inhibitors, e. g omeprazole, and pantoprazole, whose efficacy in preventing NSAID-associated ulcers has been recently demonstrated; and (iv) barrier agents, e. g. sucralfate, which cannot be recommended as prophylactic agents to prevent NSAID-induced gastropathy.", "output": {"entities": {"gene": [{"text": "histamine H2 receptor", "start": 382, "end": 403}]}}, "schema": []}
{"input": "Lung mesenchyme serves as a' compleat' inducer of lung morphogenesis by secreting soluble peptide growth factors.", "output": {"entities": {}}, "schema": []}
{"input": "The activation of the HIV promoter required the nuclear localization of c-Abl and could be correlated with increased tyrosine phosphorylation of RNA polymerase II.", "output": {"entities": {"gene": [{"text": "c-Abl", "start": 72, "end": 77}, {"text": "RNA polymerase II", "start": 145, "end": 162}]}}, "schema": []}
{"input": "The bovine papillomavirus E2 protein can inhibit the proliferation of HT-3 cells, a p53-negative cervical carcinoma cell line containing integrated human papillomavirus type 30 DNA.", "output": {"entities": {"gene": [{"text": "bovine papillomavirus E2 protein", "start": 4, "end": 36}, {"text": "p53", "start": 84, "end": 87}]}}, "schema": []}
{"input": "E2 point mutants unable to inhibit cell growth did not repress cdc25A and cdc25B expression, nor did the cell cycle inhibitors hydroxyurea and mimosine.", "output": {"entities": {"gene": [{"text": "E2", "start": 0, "end": 2}, {"text": "cdc25A", "start": 63, "end": 69}, {"text": "cdc25B", "start": 74, "end": 80}]}}, "schema": []}
{"input": "BACKGROUND/PURPOSE: Anomalous arrangement of the pancreaticobiliary duct (AAPBD) is closely related to congenital biliary dilatation and frequently associated with biliary tract malignancy.", "output": {"entities": {}}, "schema": []}
{"input": "Neurospora crassa CYT-18, can rescue the exonic trap and intron mutants which cause a structural defect.", "output": {"entities": {"gene": [{"text": "CYT-18", "start": 18, "end": 24}]}}, "schema": []}
{"input": "DDP1 also localizes to heterochromatin in interphase nuclei of larval neuroblasts.", "output": {"entities": {"gene": [{"text": "DDP1", "start": 0, "end": 4}]}}, "schema": []}
{"input": "In a reconstituted human DNA repair system containing DNA polymerase beta and DNA ligase III-XRCC1, accurate rejoining of a 3' mismatched base residue at a single-strand break is dependent on addition of the exonuclease.", "output": {"entities": {"gene": [{"text": "DNA polymerase beta", "start": 54, "end": 73}, {"text": "DNA ligase III", "start": 78, "end": 92}, {"text": "XRCC1", "start": 93, "end": 98}]}}, "schema": []}
{"input": "The PAC clone with an insert size of 120kb was isolated and mapped by restriction analysis.", "output": {"entities": {}}, "schema": []}
{"input": "Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line.", "output": {"entities": {"gene": [{"text": "10q24 locus", "start": 12, "end": 23}, {"text": "HOX11 oncogene", "start": 40, "end": 54}, {"text": "HUG1", "start": 74, "end": 78}]}}, "schema": []}
{"input": "About 20 kb upstream of LAMB2 we found a gene encoding a transcribed, non-processed LAMB2-like pseudogene (LAMB2L).", "output": {"entities": {"gene": [{"text": "LAMB2", "start": 24, "end": 29}, {"text": "LAMB2-like pseudogene", "start": 84, "end": 105}, {"text": "LAMB2L", "start": 107, "end": 113}]}}, "schema": []}
{"input": "Site-directed mutagenesis of the R2 protein was used to provide evidence that this motif is also part of the active site of the endonuclease encoded by this element.", "output": {"entities": {"gene": [{"text": "R2 protein", "start": 33, "end": 43}]}}, "schema": []}
{"input": "The infected cell protein no. 0 (ICP0) of herpes simplex virus 1 is a promiscuous transactivator shown to enhance the expression of genes introducted into cells by infection or transfection.", "output": {"entities": {"gene": [{"text": "infected cell protein no. 0", "start": 4, "end": 31}, {"text": "ICP0", "start": 33, "end": 37}]}}, "schema": []}
{"input": "Wrist measurement of blood pressure: some critical remarks to oscillometry.", "output": {"entities": {}}, "schema": []}
{"input": "G-box-directed expression in leaves required the presence of an enhancer region from the cauliflower mosaic virus (CaMV) 35S promoter.", "output": {"entities": {"gene": [{"text": "35S promoter", "start": 121, "end": 133}]}}, "schema": []}
{"input": "Another element necessary for augmenting the amplitude of the oscillation lies between-178 and-264.", "output": {"entities": {}}, "schema": []}
{"input": "This scFv was therefore used as control in experiments where another anti-Ras scFv (Y259 scFv, derived from the neutralizing anti-Ras mAb Y13-259) blocked the Ras pathway in vitro and led to tumor regression in a nude mouse model [Cochet, O., Kenigsberg, M., Delumeau, I., Virone-Oddos, A., Multon, M. C., Fridman, W. H., Schweighoffer, F., Teillaud, J. L., Tocque, B., 1998.", "output": {"entities": {"gene": [{"text": "anti-Ras scFv", "start": 69, "end": 82}, {"text": "Y259 scFv", "start": 84, "end": 93}, {"text": "anti-Ras mAb Y13-259", "start": 125, "end": 145}, {"text": "Ras", "start": 159, "end": 162}]}}, "schema": []}
{"input": "There was no competition between activin A and OP-1 for availability of Smad4, indicating that the concentration of this common signal transducer is not limiting for generating the observed biological responses.", "output": {"entities": {"gene": [{"text": "activin A", "start": 33, "end": 42}, {"text": "OP-1", "start": 47, "end": 51}, {"text": "Smad4", "start": 72, "end": 77}]}}, "schema": []}
{"input": "Our data therefore indicate that it is possible to engineer the HA envelope glycoprotein by fusing ligands to its amino-terminal end without affecting its fusion activity.", "output": {"entities": {"gene": [{"text": "HA envelope glycoprotein", "start": 64, "end": 88}]}}, "schema": []}
{"input": "However, the favored, parallel beta helix model is a compact coil of ten helically arranged beta strands forming two parallel beta sheet faces.", "output": {"entities": {}}, "schema": []}
{"input": "This is predicted to encode a 315-residue protein containing seven hydrophobic helical regions and a 17 amino acid motif characteristic of the R7G family of G-protein coupled membrane-bound receptors.", "output": {"entities": {"gene": [{"text": "R7G family", "start": 143, "end": 153}, {"text": "G-protein coupled membrane-bound receptors", "start": 157, "end": 199}]}}, "schema": []}
{"input": "Characterisation of the chicken apolipoprotein A-I gene 5'-flanking region.", "output": {"entities": {"gene": [{"text": "chicken apolipoprotein A-I gene", "start": 24, "end": 55}]}}, "schema": []}
{"input": "These results suggest that members of the ATF family are involved in mediating the transcriptional regulation of the KGF gene in response to extracellular stimuli via a novel CRE regulatory element.", "output": {"entities": {"gene": [{"text": "ATF family", "start": 42, "end": 52}, {"text": "KGF gene", "start": 117, "end": 125}]}}, "schema": []}
{"input": "Moreover, a high proportion of blood samples from a random sample of the rest of the suspects tested positive for trypanosome-specific DNA by PCR (79. 9% for T. b. gambiense and 13. 9% for T. b. rhodesiense).", "output": {"entities": {}}, "schema": []}
{"input": "A multi-centre evaluation of the card indirect agglutination test for trypanosomiasis (TrypTect CIATT).", "output": {"entities": {}}, "schema": []}
{"input": "Results for men who drank up to two drinks per day suggest that if the dependence criteria were invalid, reductions in the prevalence of specific indicators of alcohol dependence would range from 0. 3% to 5. 2%.", "output": {"entities": {}}, "schema": []}
{"input": "Mutagenesis of the CDE/CHR elements and Sp1 sites in this region, alone or in combination, reduced transcriptional activity by 40-60% in asynchronously growing cells and abolished cell cycle periodicity in G2-M-synchronized cells.", "output": {"entities": {"gene": [{"text": "Sp1 sites", "start": 40, "end": 49}]}}, "schema": []}
{"input": "Using Scheffe' s procedure as an illustration, comparisons are made to usual sample size methods that incorrectly ignore the stochastic nature of S2p.", "output": {"entities": {}}, "schema": []}
{"input": "The crystal structure of the VP16 core has been determined at 2. 1 A resolution.", "output": {"entities": {"gene": [{"text": "VP16 core", "start": 29, "end": 38}]}}, "schema": []}
{"input": "The latter method adds clamping of the inferior vena cava, which results in hypotension, requiring invasive anesthetic management.", "output": {"entities": {}}, "schema": []}
{"input": "By contrast, PvirE or Plac promoter constructs yielded functional VirE2 only if virE1 was coexpressed with virE2.", "output": {"entities": {"gene": [{"text": "PvirE", "start": 13, "end": 18}, {"text": "Plac promoter constructs", "start": 22, "end": 46}, {"text": "VirE2", "start": 66, "end": 71}, {"text": "virE1", "start": 80, "end": 85}, {"text": "virE2", "start": 107, "end": 112}]}}, "schema": []}
{"input": "Simian parainfluenza virus 5 (SV5) is a prototype of the Paramyxoviridae family of nonsegmented negative-sense RNA viruses.", "output": {"entities": {}}, "schema": []}
{"input": "To investigate the functions of GE, IG, and GS sequences in transcription, we constructed plasmids containing cDNAs of the full-length SV5 genome in which the gene junction sequences (GE, IG, and GS sequences) located between the hemagglutinin-neuraminidase (HN) and the polymerase (L) genes were replaced with the counterpart sequences from other gene junctions.", "output": {"entities": {"gene": [{"text": "hemagglutinin-neuraminidase", "start": 230, "end": 257}, {"text": "HN", "start": 259, "end": 261}, {"text": "polymerase (L) genes", "start": 271, "end": 291}]}}, "schema": []}
{"input": "CXCR4 is a chemokine receptor and a coreceptor for T-cell-line-tropic (X4) and dual-tropic (R5X4) human immunodeficiency virus type 1 (HIV-1) isolates.", "output": {"entities": {"gene": [{"text": "CXCR4", "start": 0, "end": 5}]}}, "schema": []}
{"input": "These data will help us to better detail the CXCR4 structural requirements exhibited by different HIV-1 strains and will direct further mutagenesis efforts aimed at better defining the domains in CXCR4 involved in the HIV-1 Env-mediated fusion process.", "output": {"entities": {"gene": [{"text": "CXCR4", "start": 45, "end": 50}, {"text": "CXCR4", "start": 196, "end": 201}, {"text": "Env", "start": 224, "end": 227}]}}, "schema": []}
{"input": "The results of these analyses indicate that the proteinase cleaves at amino acid residues E960-A961, E1071-S1072, E1345-T1346, and E1419-G1420; however, the cleavage efficiency is varied.", "output": {"entities": {}}, "schema": []}
{"input": "y.", "output": {"entities": {}}, "schema": []}
{"input": "SM is also shown to be associated in vivo with other components of the CRM 1 export pathway, including the small GTPase Ran and the nucleoporin CAN/Nup214.", "output": {"entities": {"gene": [{"text": "SM", "start": 0, "end": 2}, {"text": "CRM 1", "start": 71, "end": 76}, {"text": "small GTPase Ran", "start": 107, "end": 123}, {"text": "CAN", "start": 144, "end": 147}, {"text": "Nup214", "start": 148, "end": 154}]}}, "schema": []}
{"input": "Identification of a spliced gene from Kaposi' s sarcoma-associated herpesvirus encoding a protein with similarities to latent membrane proteins 1 and 2A of Epstein-Barr virus.", "output": {"entities": {"gene": [{"text": "latent membrane proteins 1 and 2A of Epstein-Barr virus", "start": 119, "end": 174}]}}, "schema": []}
{"input": "Auditory clicks were given at a rate of 20 s (-1).", "output": {"entities": {}}, "schema": []}
{"input": "Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner.", "output": {"entities": {"gene": [{"text": "Myosin light chain kinase", "start": 0, "end": 25}, {"text": "Ras", "start": 50, "end": 53}, {"text": "ERK", "start": 54, "end": 57}, {"text": "urokinase-type plasminogen activator", "start": 82, "end": 118}, {"text": "integrin", "start": 142, "end": 150}]}}, "schema": []}
{"input": "The inhibition of StAR gene transcription by DAX-1 was dose-dependent reducing transcription to 6% of control levels.", "output": {"entities": {"gene": [{"text": "StAR gene", "start": 18, "end": 27}, {"text": "DAX-1", "start": 45, "end": 50}]}}, "schema": []}
{"input": "In a prospective randomized study, 287 patients with advanced non-small cell lung cancer (NSCLC) stage IIIb or IV with ECOG performance status (PS) 0-1 or 2 were randomly assigned to receive either best supportive care (BSC) or supportive care plus combination chemotherapy (IEP regimen: ifosfamide 3 gm/m2 IV with mesna uroprotection, epirubicin 60 mg/m2 IV on day 1 and cisplatin 60 mg/m2 IV on day 2; or MVP regimen: mitomycin-C 8 mg/m2, cisplatin 100 mg/m2 IV on day 1, vinblastine 4 mg/m2 IV on days 1 and 15).", "output": {"entities": {}}, "schema": []}
{"input": "The transcriptional activities of the full-length promoter (-295 to + 85) and of three deletion constructs (-197,-154 and-74 to + 85) were significantly down-regulated in resistant cells.", "output": {"entities": {}}, "schema": []}
{"input": "A 13-bp cis-regulatory element in the LTR promoter of the tobacco retrotransposon Tto1 is involved in responsiveness to tissue culture, wounding, methyl jasmonate and fungal elicitors.", "output": {"entities": {"gene": [{"text": "tobacco retrotransposon Tto1", "start": 58, "end": 86}]}}, "schema": []}
{"input": "In this study we describe that platelet-derived growth factor (PDGF), 12-O-tetradecanoyl-phorbol-acetate (TPA), and forskolin induced CREB (cAMP-responsive element-binding protein) Ser-133 phosphorylation with comparable magnitude and kinetics in NIH 3T3 cells.", "output": {"entities": {"gene": [{"text": "platelet-derived growth factor", "start": 31, "end": 61}, {"text": "PDGF", "start": 63, "end": 67}, {"text": "CREB", "start": 134, "end": 138}, {"text": "cAMP-responsive element-binding protein", "start": 140, "end": 179}]}}, "schema": []}
{"input": "This constitutes evidence for an in vivo role of SRC-1 in dimerization-induced activation by OR1/RXRalpha.", "output": {"entities": {"gene": [{"text": "SRC-1", "start": 49, "end": 54}, {"text": "OR1", "start": 93, "end": 96}, {"text": "RXRalpha", "start": 97, "end": 105}]}}, "schema": []}
{"input": "By contrast, mTRAP100 coprecipitates in vivo with another component of the TRAP complex (TRAP220), which directly contacts TR and the vitamin D receptor in a ligand-dependent manner.", "output": {"entities": {"gene": [{"text": "mTRAP100", "start": 13, "end": 21}, {"text": "TRAP complex", "start": 75, "end": 87}, {"text": "TRAP220", "start": 89, "end": 96}, {"text": "TR", "start": 123, "end": 125}, {"text": "vitamin D receptor", "start": 134, "end": 152}]}}, "schema": []}
{"input": "This sequence also confers VDR and vitamin D responsiveness to a heterologous promoter.", "output": {"entities": {"gene": [{"text": "VDR", "start": 27, "end": 30}]}}, "schema": []}
{"input": "Expression of GlcNAc-TI mRNA in tobacco leaves was detected using RT-PCR.", "output": {"entities": {"gene": [{"text": "GlcNAc-TI mRNA", "start": 14, "end": 28}]}}, "schema": []}
{"input": "Chemical stability tests and site-specific mutagenesis identified amino acids H219 and D63 of RegS and RegR, respectively, as the phosphorylated residues.", "output": {"entities": {"gene": [{"text": "RegS", "start": 94, "end": 98}, {"text": "RegR", "start": 103, "end": 107}]}}, "schema": []}
{"input": "An overexpression of the betaAPP gene in certain areas of the AD brain has been suggested to be an important factor in the neuropathology of AD.", "output": {"entities": {"gene": [{"text": "betaAPP gene", "start": 25, "end": 37}]}}, "schema": []}
{"input": "For functional studies, two promoter regions were cloned upstream of the reporter gene, chloramphenicol acetyl transferase (CAT): (i) phbetaE-B-the plasmid that contains the human (h) promoter region (-2832 to + 101) including URE, and (ii) prhbetaE-B-the plasmid that contains the rhesus (rh) promoter region excluding URE as it lacks a 270 bp region of the hbetaAPP promoter (-2435 to-2165).", "output": {"entities": {"gene": [{"text": "chloramphenicol acetyl transferase", "start": 88, "end": 122}, {"text": "CAT", "start": 124, "end": 127}, {"text": "hbetaAPP promoter", "start": 359, "end": 376}]}}, "schema": []}
{"input": "67 393 bp of contiguous DNA located between markers cdc18 and cdc14 on the right arm of fission yeast chromosome II has been sequenced as part of the European Union Schizosaccharomyces pombe genome sequencing project.", "output": {"entities": {"gene": [{"text": "cdc18", "start": 52, "end": 57}, {"text": "cdc14", "start": 62, "end": 67}]}}, "schema": []}
{"input": "67 393 bp of contiguous DNA located between markers cdc18 and cdc14 on the right arm of fission yeast chromosome II has been sequenced as part of the European Union Schizosaccharomyces pombe genome sequencing project.", "output": {"entities": {"gene": [{"text": "cdc18", "start": 52, "end": 57}, {"text": "cdc14", "start": 62, "end": 67}]}}, "schema": []}
{"input": "G-CSF (480 micrograms subcutaneously (s. c.)) were used in 55 and GM-CSF (400 micrograms s. c.) in 28 chemotherapeutic cycles.", "output": {"entities": {"gene": [{"text": "G-CSF", "start": 0, "end": 5}, {"text": "GM-CSF", "start": 66, "end": 72}]}}, "schema": []}
{"input": "Overexpression of H411 cDNA in the RAW 264. 7 macrophage cell line promoted an increased growth rate, suggesting that expression of H411 is part of the proliferative cell response to LPS.", "output": {"entities": {"gene": [{"text": "H411 cDNA", "start": 18, "end": 27}, {"text": "H411", "start": 132, "end": 136}]}}, "schema": []}
{"input": "Human expressed sequence tag clones were identified by sequence similarity to mammalian and yeast oligosaccharide-processing mannosidases, and the full-length coding region of the putative mannosidase homolog was isolated by a combination of 5'-rapid amplification of cDNA ends and direct polymerase chain reaction from human placental cDNA.", "output": {"entities": {"gene": [{"text": "mammalian and yeast oligosaccharide-processing mannosidases", "start": 78, "end": 137}, {"text": "mannosidase homolog", "start": 189, "end": 208}]}}, "schema": []}
{"input": "Activation of ERK1/2 is correlated with induction of the immediate-early response genes.", "output": {"entities": {"gene": [{"text": "ERK1/2", "start": 14, "end": 20}, {"text": "immediate-early response genes", "start": 57, "end": 87}]}}, "schema": []}
{"input": "The transcription of most RP genes is activated by two Rap1p binding sites, 250 to 400 bp upstream from the initiation of transcription.", "output": {"entities": {"gene": [{"text": "RP genes", "start": 26, "end": 34}, {"text": "Rap1p binding sites", "start": 55, "end": 74}]}}, "schema": []}
{"input": "We have isolated three mutant alleles of CDC4 (cdc4-10, cdc4-11, and cdc4-16) which suppress the nuclear division defect of cdc20-1 cells.", "output": {"entities": {"gene": [{"text": "CDC4", "start": 41, "end": 45}, {"text": "cdc4-10", "start": 47, "end": 54}, {"text": "cdc4-11", "start": 56, "end": 63}, {"text": "cdc4-16", "start": 69, "end": 76}, {"text": "cdc20-1", "start": 124, "end": 131}]}}, "schema": []}
{"input": "Role of secondary structure in discrimination between constitutive and inducible activators.", "output": {"entities": {}}, "schema": []}
{"input": "In summary, Ca (2 +)-dependent activation of NO production mediates apoptosis after TG exposure in JT/Neo cells.", "output": {"entities": {"gene": [{"text": "TG", "start": 84, "end": 86}]}}, "schema": []}
{"input": "Accumulation of the U4/U6 duplex was relieved by overexpression of wild-type Prp44p.", "output": {"entities": {"gene": [{"text": "U4", "start": 20, "end": 22}, {"text": "U6", "start": 23, "end": 25}, {"text": "wild-type Prp44p", "start": 67, "end": 83}]}}, "schema": []}
{"input": "Our results, when combined with previously published in vitro results, support a direct role for Prp44p in unwinding of the U4/U6 helix.", "output": {"entities": {"gene": [{"text": "Prp44p", "start": 97, "end": 103}, {"text": "U4", "start": 124, "end": 126}, {"text": "U6", "start": 127, "end": 129}]}}, "schema": []}
{"input": "This approximately 125-nt RNA proved to arise via RNase E cleavage from the 3'-terminal region of the mRNAs bearing the terminator.", "output": {"entities": {"gene": [{"text": "RNase E", "start": 50, "end": 57}]}}, "schema": []}
{"input": "The mysteries of geographic variability in nonmelanoma skin cancer incidence.", "output": {"entities": {}}, "schema": []}
{"input": "In Saccharomyces cerevisiae the cAMP-dependent kinases (PKAs) promote cytoplasmic growth and modulate the growth-regulated mechanism triggering the begin of DNA synthesis.", "output": {"entities": {"gene": [{"text": "cAMP-dependent kinases", "start": 32, "end": 54}, {"text": "PKAs", "start": 56, "end": 60}]}}, "schema": []}
{"input": "A recombinant derivative harboring the pMJ101 replication region proved to be compatible with pJM1, a plasmid containing the iron acquisition system required for the virulence of V. anguillarum 775, another important pathogen that causes vibriosis.", "output": {"entities": {}}, "schema": []}
{"input": "FAK localizes to sites of transmembrane integrin receptor clustering and facilitates intracellular signaling events.", "output": {"entities": {"gene": [{"text": "FAK", "start": 0, "end": 3}, {"text": "transmembrane integrin receptor", "start": 26, "end": 57}]}}, "schema": []}
{"input": "Expression of various FAK mutants in the FAK-cells showed that FAK kinase activity, the Tyr-397/SH2 domain binding site, and the first proline-rich SH3 binding region in the FAK C-terminal domain were individually needed to promote full FAK-mediated FAK-cell migration to FN whereas direct paxillin binding to FAK was not required.", "output": {"entities": {"gene": [{"text": "FAK mutants", "start": 22, "end": 33}, {"text": "FAK", "start": 41, "end": 44}, {"text": "FAK kinase", "start": 63, "end": 73}, {"text": "Tyr-397/SH2 domain binding site", "start": 88, "end": 119}, {"text": "SH3 binding region", "start": 148, "end": 166}, {"text": "FAK C-terminal domain", "start": 174, "end": 195}, {"text": "FAK", "start": 237, "end": 240}, {"text": "FAK", "start": 250, "end": 253}, {"text": "FN", "start": 272, "end": 274}, {"text": "paxillin", "start": 290, "end": 298}, {"text": "FAK", "start": 310, "end": 313}]}}, "schema": []}
{"input": "This dominant-negative effect of FRNK was reversed by a point mutation (Leu-1034 to Ser) which prevented FRNK localization to focal contact sites.", "output": {"entities": {"gene": [{"text": "FRNK", "start": 33, "end": 37}, {"text": "FRNK", "start": 105, "end": 109}]}}, "schema": []}
{"input": "Fifty six young patients (age < 45 yr) with doppler-proven DVT were investigated for the presence of resistance to activated protein C (APC-R), lupus anticoagulant (LA), anticardiolipin antibodies and deficiencies of protein C, protein S, ATIII activities.", "output": {"entities": {"gene": [{"text": "activated protein C", "start": 115, "end": 134}, {"text": "APC-R", "start": 136, "end": 141}, {"text": "anticardiolipin antibodies", "start": 170, "end": 196}, {"text": "protein C", "start": 217, "end": 226}, {"text": "protein S", "start": 228, "end": 237}, {"text": "ATIII", "start": 239, "end": 244}]}}, "schema": []}
{"input": "DESIGN: Comparison of number of women with PKU aged 15-44 years on the NSW PKU database (observed number) with expected number derived from population data.", "output": {"entities": {}}, "schema": []}
{"input": "PURPOSE: The purposes of the present study were to assess the effects of a 12-wk laboratory based aerobic exercise program on cardiopulmonary function, CD4 cell count, and physician-assessed health status among symptomatic pre-AIDS HIV-infected individuals (N = 28) and to assess the degree to which ill health was associated with exercise relapse.", "output": {"entities": {"gene": [{"text": "CD4", "start": 152, "end": 155}]}}, "schema": []}
{"input": "Epidemiologic evidence indicates that estrogen replacement therapy after menopause increases breast cancer risk.", "output": {"entities": {}}, "schema": []}
{"input": "In addition to its elongation activity, ELL contains a novel type of RNA polymerase II interaction domain that is capable of repressing polymerase activity in promoter-specific transcription.", "output": {"entities": {"gene": [{"text": "ELL", "start": 40, "end": 43}, {"text": "RNA polymerase II interaction domain", "start": 69, "end": 105}]}}, "schema": []}
{"input": "A diagnosis of IgA lambda multiple myeloma with peritoneal involvement was made.", "output": {"entities": {"gene": [{"text": "IgA lambda", "start": 15, "end": 25}]}}, "schema": []}
{"input": "The radiation burden associated with the majority of examinations in nuclear medicine expressed as the effective dose is comparable with the radiation burden of radiodiagnostic examinations, only after administration of preparations with 131I, 201Tl, 67Ga and 111In it is markedly higher.", "output": {"entities": {}}, "schema": []}
{"input": "Although the risk of malformation in children born after ICSI is not increased there is an increased risk to transmit genetic abnormalities in case of NOA (such as the rate of sex chromosome, or microdeletions of the Y chromosome) and in case of congenital OA (mutations of the cystic fibrosis gene).", "output": {"entities": {"gene": [{"text": "cystic fibrosis gene", "start": 278, "end": 298}]}}, "schema": []}
{"input": "TaV particles have a buoyant density of 1. 296 g/cm3 in CsCl and consist of two capsid proteins of 56 and 6 kDa.", "output": {"entities": {"gene": [{"text": "capsid proteins", "start": 80, "end": 95}]}}, "schema": []}
{"input": "CONCLUSION: These results suggest that vibration-induced neural involvement can be considered neither pure digital neuropathy, nor definite CTS, as previously described.", "output": {"entities": {}}, "schema": []}
{"input": "In about 770 bp upstream region of Spam1 that has been cloned and sequenced, multiple transcription factor binding sites including a CRE (cAMP-responsive element) were found.", "output": {"entities": {"gene": [{"text": "Spam1", "start": 35, "end": 40}]}}, "schema": []}
{"input": "The in vitro relaxivity of the complex is 16. 24 s (-1) mM (-1).", "output": {"entities": {}}, "schema": []}
{"input": "Bacterial recovery of SA from the liver/spleen and the cecal tonsil in contact poults and SG from contact chicks treated with ILK was dramatically reduced when compared to non-treated contact poults and chicks.", "output": {"entities": {"gene": [{"text": "ILK", "start": 126, "end": 129}]}}, "schema": []}
{"input": "The results of the ISIS-2 trial and the data from the Antiplatelet Trialists' Collaboration indicated that aspirin is mandatory in patients with acute myocardial infarction and for secondary prevention.", "output": {"entities": {}}, "schema": []}
{"input": "This study was performed to assess the role of additional diagnostic laparoscopy in the preoperative staging of patients with adenocarcinoma of the esophagus, gastric cancer and pancreatic cancer prior to intended curative surgery.", "output": {"entities": {}}, "schema": []}
{"input": "This report presents state-specific MMRs for 1987-1996, focusing on persistent disparities in maternal mortality between black and white women.", "output": {"entities": {}}, "schema": []}
{"input": "Preheparin LPL mass level did not significantly differ in individuals from 19 to 70 years old, for both men and women.", "output": {"entities": {"gene": [{"text": "LPL", "start": 11, "end": 14}]}}, "schema": []}
{"input": "A decrease in insulin-induced receptor kinase activity was observed for solubilized chimeric receptors.", "output": {"entities": {"gene": [{"text": "insulin", "start": 14, "end": 21}]}}, "schema": []}
{"input": "Cat-1 is identical to the recently identified binding partner for the beta-adrenergic receptor kinase (betaARK or GRK-2), which was shown to have Arf-GAP activity.", "output": {"entities": {"gene": [{"text": "Cat-1", "start": 0, "end": 5}, {"text": "beta-adrenergic receptor kinase", "start": 70, "end": 101}, {"text": "betaARK", "start": 103, "end": 110}, {"text": "GRK-2", "start": 114, "end": 119}, {"text": "Arf", "start": 146, "end": 149}, {"text": "GAP", "start": 150, "end": 153}]}}, "schema": []}
{"input": "Cat proteins are tyrosine-phosphorylated when co-expressed in cells with the focal adhesion kinase Fak and Src.", "output": {"entities": {"gene": [{"text": "Cat proteins", "start": 0, "end": 12}, {"text": "focal adhesion kinase Fak", "start": 77, "end": 102}, {"text": "Src", "start": 107, "end": 110}]}}, "schema": []}
{"input": "Immunoprecipitation experiments using DokR-specific antibodies revealed an interaction between endogenous DokR and a 150-kDa protein that is tyrosine-phosphorylated in EGF-stimulated BaF/3 cells.", "output": {"entities": {"gene": [{"text": "DokR-specific antibodies", "start": 38, "end": 62}, {"text": "endogenous DokR", "start": 95, "end": 110}, {"text": "EGF", "start": 168, "end": 171}]}}, "schema": []}
{"input": "Expansins are a family of proteins that catalyse long-term extension of isolated plant cell walls due to an as yet unknown biochemical mechanism.", "output": {"entities": {"gene": [{"text": "Expansins", "start": 0, "end": 9}]}}, "schema": []}
{"input": "This review summarizes the clinical evidence to support current therapies in irritable bowel syndrome (IBS).", "output": {"entities": {}}, "schema": []}
{"input": "The responsive region of the alpha 2 (V) collagen gene was localized to a fragment including 100 bp of basal promoter and 150 bp of exon 1 sequences, which contained two CRE-like elements.", "output": {"entities": {"gene": [{"text": "alpha 2 (V) collagen gene", "start": 29, "end": 54}]}}, "schema": []}
{"input": "Furthermore, addition of B-Myb-glutathionine S-transferase fusion protein inhibited complex formation.", "output": {"entities": {"gene": [{"text": "B-Myb", "start": 25, "end": 30}, {"text": "glutathionine S-transferase", "start": 31, "end": 58}]}}, "schema": []}
{"input": "APOE-epsilon4 count predicts age when prevalence of AD increases, then declines: the Cache County Study.", "output": {"entities": {"gene": [{"text": "APOE", "start": 0, "end": 4}]}}, "schema": []}
{"input": "A new DNA repair gene from Schizosaccharomyces pombe with homology to RecA was identified and characterized.", "output": {"entities": {"gene": [{"text": "DNA repair gene", "start": 6, "end": 21}, {"text": "RecA", "start": 70, "end": 74}]}}, "schema": []}
{"input": "Among mucus-secreting cells, the gastric gland mucous cells, Brunner' s glands, accessory glands of pancreaticobiliary tract, and pancreatic ducts exhibiting gastric metaplasia are unique in that they express class III mucin identified by paradoxical Con A staining composed of periodate oxidation, sodium borohydride reduction, Con A, and horseradish peroxidase reaction.", "output": {"entities": {"gene": [{"text": "class III mucin", "start": 209, "end": 224}, {"text": "Con A", "start": 251, "end": 256}, {"text": "Con A", "start": 329, "end": 334}, {"text": "horseradish peroxidase", "start": 340, "end": 362}]}}, "schema": []}
{"input": "The C-terminal mutants were strongly dominant over TraR, suggesting that they can form heteromultimers with the wild-type activator.", "output": {"entities": {"gene": [{"text": "TraR", "start": 51, "end": 55}]}}, "schema": []}
{"input": "The data imply that JAK/STAT signaling has a role in EBV-associated malignancies.", "output": {"entities": {"gene": [{"text": "JAK", "start": 20, "end": 23}, {"text": "STAT", "start": 24, "end": 28}]}}, "schema": []}
{"input": "There were 27 men and 156 women.", "output": {"entities": {}}, "schema": []}
{"input": "A., Bowers, K. E, and Matthews, C.", "output": {"entities": {}}, "schema": []}
{"input": "Spfkh1 is transcribed in one open reading frame that contains the DNA binding domain, nuclear localization signal and transactivation domain.", "output": {"entities": {"gene": [{"text": "Spfkh1", "start": 0, "end": 6}]}}, "schema": []}
{"input": "The molecular mechanism of Tax-mediated trans-activation has been well investigated.", "output": {"entities": {"gene": [{"text": "Tax", "start": 27, "end": 30}]}}, "schema": []}
{"input": "METHODS: 109 suspected cases with SS underwent the biopsies.", "output": {"entities": {}}, "schema": []}
{"input": "We also identify several regulatory domain mutants in which Cd (2 +) tolerance of the mutant strain and transport activity of the protein are dissociated.", "output": {"entities": {}}, "schema": []}
{"input": "The human immunodeficiency virus type-1 (HIV-1) Tat protein regulates transcription by stimulating RNA polymerase processivity.", "output": {"entities": {"gene": [{"text": "human immunodeficiency virus type-1 (HIV-1) Tat protein", "start": 4, "end": 59}, {"text": "RNA polymerase", "start": 99, "end": 113}]}}, "schema": []}
{"input": "One of these SEBPs, SEBP2, was shown to be the product of the homeotic gene fork head.", "output": {"entities": {"gene": [{"text": "SEBPs", "start": 13, "end": 18}, {"text": "SEBP2", "start": 20, "end": 25}, {"text": "homeotic gene fork head", "start": 62, "end": 85}]}}, "schema": []}
{"input": "Identity elements in tRNA for mono-and dimethylation reactions by the recombinant pfTrm1p were identified using in vitro T7 transcripts of 33 variants of tRNA (Asp) and tRNA (Phe) from yeast.", "output": {"entities": {"gene": [{"text": "recombinant pfTrm1p", "start": 70, "end": 89}, {"text": "tRNA (Asp)", "start": 154, "end": 164}, {"text": "tRNA (Phe)", "start": 169, "end": 179}]}}, "schema": []}
{"input": "In insulin-responsive cells, Akt phosphorylates and inactivates the serine/threonine kinase glycogen synthase kinase-3 (GSK-3).", "output": {"entities": {"gene": [{"text": "insulin", "start": 3, "end": 10}, {"text": "Akt", "start": 29, "end": 32}, {"text": "serine/threonine kinase glycogen synthase kinase-3", "start": 68, "end": 118}, {"text": "GSK-3", "start": 120, "end": 125}]}}, "schema": []}
{"input": "The B cell antigen receptor activates the Akt (protein kinase B)/glycogen synthase kinase-3 signaling pathway via phosphatidylinositol 3-kinase.", "output": {"entities": {"gene": [{"text": "B cell antigen receptor", "start": 4, "end": 27}, {"text": "Akt", "start": 42, "end": 45}, {"text": "protein kinase B", "start": 47, "end": 63}, {"text": "glycogen synthase kinase-3", "start": 65, "end": 91}, {"text": "phosphatidylinositol 3-kinase", "start": 114, "end": 143}]}}, "schema": []}
{"input": "Fewer recombination events are detected in four different B and T cell lines that do not undergo switch recombination of their endogenous genes.", "output": {"entities": {}}, "schema": []}
{"input": "IL-1 and TNF increase AND-34 transcript levels in thymic cortical reticular, thymic nurse, and fibroblast cell lines.", "output": {"entities": {"gene": [{"text": "IL-1", "start": 0, "end": 4}, {"text": "TNF", "start": 9, "end": 12}, {"text": "AND-34 transcript", "start": 22, "end": 39}]}}, "schema": []}
{"input": "To determine what role eIF4E might play in c-myc expression, the c-myc 5' untranslated region (UTR) was fused in-frame to CAT reporters, and several more derivative constructs were made.", "output": {"entities": {"gene": [{"text": "eIF4E", "start": 23, "end": 28}, {"text": "c-myc", "start": 43, "end": 48}, {"text": "c-myc 5' untranslated region (UTR)", "start": 65, "end": 99}, {"text": "CAT reporters", "start": 122, "end": 135}]}}, "schema": []}
{"input": "Analysis of cell cycle proteins showed that 24 h of lovastatin treatment in the control cells caused an elevation in the levels of the cyclin-dependent kinase inhibitor p27 (kip1), inhibition of both cyclin E-and cyclin A-dependent kinase activity, and decreased levels of hyperphosphorylated retinoblastoma protein (pRb).", "output": {"entities": {"gene": [{"text": "cyclin-dependent kinase", "start": 135, "end": 158}, {"text": "p27", "start": 169, "end": 172}, {"text": "kip1", "start": 174, "end": 178}, {"text": "cyclin E-and cyclin A-dependent kinase", "start": 200, "end": 238}, {"text": "retinoblastoma protein", "start": 293, "end": 315}, {"text": "pRb", "start": 317, "end": 320}]}}, "schema": []}
{"input": "RESULTS: Circulating leptin concentrations in AN were 3. 5 +/-0. 5 versus 7. 6 +/-1. 2 ng/ml in control subjects.", "output": {"entities": {"gene": [{"text": "leptin", "start": 21, "end": 27}]}}, "schema": []}
{"input": "Copyright 1999 Academic Press.", "output": {"entities": {}}, "schema": []}
{"input": "Oligonucleotide probes corresponding to wild-type and mutant EpRE sequences were used in gel-shift and super-shift analyses to identify proteins binding.", "output": {"entities": {}}, "schema": []}
{"input": "PKNbeta had high sequence homology with PKNalpha, originally isolated PKN, especially in the repeats of charged amino acid-rich region with leucine-zipper like sequences (CZ region/HR1), in the carboxyl-terminal catalytic domain, and in approximately 130 amino acid stretch (D region/HR2), located between CZ region/HR1 and the catalytic domain.", "output": {"entities": {"gene": [{"text": "PKNbeta", "start": 0, "end": 7}, {"text": "PKNalpha", "start": 40, "end": 48}, {"text": "PKN", "start": 70, "end": 73}]}}, "schema": []}
{"input": "At baseline, serum levels of lycopene and FLOP were abnormally high and serum FLOP was correlated significantly with plasma cyclosporine levels (r = 0. 646, p = 0. 016).", "output": {"entities": {}}, "schema": []}
{"input": "BACKGROUND: Chronic alcohol consumption has been demonstrated to be deleterious to bone health.", "output": {"entities": {}}, "schema": []}
{"input": "Interestingly, following induction of stress by heat shock, high salt, or ethanol, conditions under which most mRNA export is blocked, Npl3p is still exported from the nucleus.", "output": {"entities": {"gene": [{"text": "Npl3p", "start": 135, "end": 140}]}}, "schema": []}
{"input": "For symptomatic relief and inhibition of the growth of the metastases interferon-a and somatostatin analogues can be employed.", "output": {"entities": {"gene": [{"text": "interferon-a", "start": 70, "end": 82}, {"text": "somatostatin", "start": 87, "end": 99}]}}, "schema": []}
{"input": "In summary, the no-adverse-effect-level for this study was determined to be 1000 ppm, based on decreased weight gain in female rats, and on slight organ weight changes in both sexes at 3000 ppm.", "output": {"entities": {}}, "schema": []}
{"input": "Some of them produce gigantic sperm several times the total male body length.", "output": {"entities": {}}, "schema": []}
{"input": "PDGF A-chain levels increase in cultured vascular smooth muscle cells (SMCs) exposed to ATII.", "output": {"entities": {"gene": [{"text": "PDGF A-chain", "start": 0, "end": 12}, {"text": "ATII", "start": 88, "end": 92}]}}, "schema": []}
{"input": "M-Ras interacted poorly in a yeast two-hybrid assay with multiple Ras effectors, including c-Raf-1, A-Raf, B-Raf, phosphoinositol-3 kinase delta, RalGDS, and Rin1.", "output": {"entities": {"gene": [{"text": "M-Ras", "start": 0, "end": 5}, {"text": "Ras", "start": 66, "end": 69}, {"text": "c-Raf-1", "start": 91, "end": 98}, {"text": "A-Raf", "start": 100, "end": 105}, {"text": "B-Raf", "start": 107, "end": 112}, {"text": "phosphoinositol-3 kinase delta", "start": 114, "end": 144}, {"text": "RalGDS", "start": 146, "end": 152}, {"text": "Rin1", "start": 158, "end": 162}]}}, "schema": []}
{"input": "Deletion mapping of the human presenilin-1 (PS1) promoter delineated the most active fragment from-118 to + 178 in relation to the transcription start site mapped in this study, in both human neuroblastoma SK-N-SH and hepatoma HepG2 cells.", "output": {"entities": {"gene": [{"text": "human presenilin-1", "start": 24, "end": 42}, {"text": "PS1", "start": 44, "end": 47}]}}, "schema": []}
{"input": "Analysis of the E2F1 gene promoter showed that the-146 to-54 region was required for E2-responsiveness in transient transfection assays, and subsequent deletion/mutation analysis showed that a single upstream GC-rich and two downstream CCAAT-binding sites were required for transactivation by E2.", "output": {"entities": {"gene": [{"text": "E2F1 gene promoter", "start": 16, "end": 34}, {"text": "E2", "start": 85, "end": 87}, {"text": "E2", "start": 293, "end": 295}]}}, "schema": []}
{"input": "In the course of investigating the mechanisms by which OF5 and OF3 regulated CYP11A1 transcription, we found that OF5 and OF3 bound Sp1 and Sp3 in JEG-3 cells.", "output": {"entities": {"gene": [{"text": "OF5", "start": 55, "end": 58}, {"text": "OF3", "start": 63, "end": 66}, {"text": "CYP11A1", "start": 77, "end": 84}, {"text": "OF5", "start": 114, "end": 117}, {"text": "OF3", "start": 122, "end": 125}, {"text": "Sp1", "start": 132, "end": 135}, {"text": "Sp3", "start": 140, "end": 143}]}}, "schema": []}
{"input": "In contrast, the differentiation of neoplastically transformed cells does not repress mitogenic responsiveness or junB or c-fos inducibility.", "output": {"entities": {"gene": [{"text": "junB", "start": 114, "end": 118}, {"text": "c-fos", "start": 122, "end": 127}]}}, "schema": []}
{"input": "Adipocyte differentiation of nontransformed cells also markedly represses the ability of SRF to bind to the junB SRE, the c-fos SRE, and other SREs, as determined by mobility shift and gel supershift assays, without affecting the DNA binding characteristics of the nuclear protein SP-1.", "output": {"entities": {"gene": [{"text": "SRF", "start": 89, "end": 92}, {"text": "junB", "start": 108, "end": 112}, {"text": "c-fos", "start": 122, "end": 127}]}}, "schema": []}
{"input": "Transformation blocks differentiation-induced inhibition of serum response factor interactions with serum response elements.", "output": {"entities": {"gene": [{"text": "serum response factor", "start": 60, "end": 81}]}}, "schema": []}
{"input": "The core enzyme is homologous to those of bacteriophages T3, T7 and SP6 whereas the specificity factor shows similarities with bacterial sigma factors.", "output": {"entities": {"gene": [{"text": "core enzyme", "start": 4, "end": 15}, {"text": "bacterial sigma factors", "start": 127, "end": 150}]}}, "schema": []}
{"input": "The Cr. psbA-4 ORF contains an H-N-H motif, and possibly a GIY-YIG motif.", "output": {"entities": {"gene": [{"text": "Cr. psbA-4 ORF", "start": 4, "end": 18}]}}, "schema": []}
{"input": "The interaction of zf4-6 with full-length 5 S RNA was far more sensitive to non-specific competitor concentration than was the zf4-7: 5 S RNA interaction, suggesting that finger seven contributes to both affinity and specificity in this protein: RNA interaction.", "output": {"entities": {"gene": [{"text": "zf4-6", "start": 19, "end": 24}, {"text": "full-length 5 S RNA", "start": 30, "end": 49}, {"text": "zf4-7", "start": 127, "end": 132}, {"text": "5 S RNA", "start": 134, "end": 141}]}}, "schema": []}
{"input": "The STAT protein accumulation resulting from C/EBP expression was tightly coupled to the morphological conversion of fibroblasts to adipocytes and represents an expression profile identical to that reported for mature adipocytes in vivo.", "output": {"entities": {"gene": [{"text": "STAT protein", "start": 4, "end": 16}, {"text": "C/EBP", "start": 45, "end": 50}]}}, "schema": []}
{"input": "The median durations for response and survival time in the late phase II trial were 2. 3 months and 5. 8 months, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "The role of' scientific psychiatry' in understanding patients with chronic schizophrenia or severe personality disorder.", "output": {"entities": {}}, "schema": []}
{"input": "Myocardial antioxidant enzymes, catalase, glutathione peroxidase and superoxide dismutase, in the MCT-treated rats were not different compared to control rats.", "output": {"entities": {"gene": [{"text": "catalase", "start": 32, "end": 40}, {"text": "glutathione peroxidase", "start": 42, "end": 64}, {"text": "superoxide dismutase", "start": 69, "end": 89}]}}, "schema": []}
{"input": "The second goal was to ascertain the somatotopic arrangement of the GPi in PD.", "output": {"entities": {}}, "schema": []}
{"input": "These overall results indicate that there is generally one PERV copy per integration site.", "output": {"entities": {}}, "schema": []}
{"input": "OBJECTIVE: To determine whether administration of misoprostol prevents gastric hemorrhage in healthy dogs treated with high doses of methylprednisolone sodium succinate (MPSS).", "output": {"entities": {}}, "schema": []}
{"input": "Patients were assessed for cardiac MIBG uptake, circulating norepinephrine concentration, LVEF, peak Vo2, x-ray cardiothoracic ratio, M-mode echographic end-diastolic diameter and right-sided heart catheterization parameters.", "output": {"entities": {}}, "schema": []}
{"input": "Nuclear hormone receptors (NRs) are ligand-inducible transcription factors that mediate critical functions in many species.", "output": {"entities": {}}, "schema": []}
{"input": "These cells were able to present influenza virus particles to HLA-DR1-restricted T cell clones.", "output": {"entities": {"gene": [{"text": "HLA-DR1", "start": 62, "end": 69}]}}, "schema": []}
{"input": "Sequencing of zebrafish (Danio rerio) bacterial artificial chromosome and P1 artificial chromosome genomic clone fragments and of cDNA clones has led to the identification of five new loci coding for beta subunits of proteasomes (PSMB).", "output": {"entities": {"gene": [{"text": "PSMB", "start": 230, "end": 234}]}}, "schema": []}
{"input": "In addition to homologues of the human genes PSMB5 through PSMB9, two new genes, PSMB11 and PSMB12, have been found for which there are no known corresponding genes in humans.", "output": {"entities": {"gene": [{"text": "human genes PSMB5", "start": 33, "end": 50}, {"text": "PSMB9", "start": 59, "end": 64}, {"text": "PSMB11", "start": 81, "end": 87}, {"text": "PSMB12", "start": 92, "end": 98}]}}, "schema": []}
{"input": "It applies Udry' s biosocial perspective, which attempts to reconcile the biological and sociological models of premarital sexual and reproductive behaviour.", "output": {"entities": {}}, "schema": []}
{"input": "Weight and height z-scores were significantly associated with BMD z-scores.", "output": {"entities": {}}, "schema": []}
{"input": "A limited sampling strategy was used based on a bayesian parameter estimation algorithm that is part of the ADAPT II software package.", "output": {"entities": {}}, "schema": []}
{"input": "The amino acid changes D206A and D208A abolish singly or in combination the exonuclease activity in vivo.", "output": {"entities": {}}, "schema": []}
{"input": "Previous experimental evidence had indicated that Reg1 might target Glc7 to nuclear substrates such as the Snf1 kinase complex.", "output": {"entities": {"gene": [{"text": "Reg1", "start": 50, "end": 54}, {"text": "Glc7", "start": 68, "end": 72}, {"text": "Snf1 kinase complex", "start": 107, "end": 126}]}}, "schema": []}
{"input": "In the present study, we demonstrate that expression of TD-IkappaBalpha blocked phorbol myristate acetate-phytohemagglutinin or tumor necrosis factor alpha-induced IkappaBalpha gene transcription and abolished NF-kappaB DNA binding activity, due to the continued cytoplasmic sequestration of RelA (p65) by TD-IkappaBalpha.", "output": {"entities": {"gene": [{"text": "TD-IkappaBalpha", "start": 56, "end": 71}, {"text": "acetate-phytohemagglutinin", "start": 98, "end": 124}, {"text": "tumor necrosis factor alpha", "start": 128, "end": 155}, {"text": "IkappaBalpha gene", "start": 164, "end": 181}, {"text": "NF-kappaB", "start": 210, "end": 219}, {"text": "RelA", "start": 292, "end": 296}, {"text": "p65", "start": 298, "end": 301}, {"text": "TD-IkappaBalpha", "start": 306, "end": 321}]}}, "schema": []}
{"input": "(i) Complete Grb10 expression from cDNA with an ecdysone-regulated transient expression system stimulated PDGF-BB-, IGF-I, and insulin-but not epidermal growth factor (EGF)-induced DNA synthesis in an ecdysone dose-responsive fashion.", "output": {"entities": {"gene": [{"text": "Grb10", "start": 13, "end": 18}, {"text": "PDGF-BB", "start": 106, "end": 113}, {"text": "IGF-I", "start": 116, "end": 121}, {"text": "insulin", "start": 127, "end": 134}, {"text": "epidermal growth factor", "start": 143, "end": 166}, {"text": "EGF", "start": 168, "end": 171}]}}, "schema": []}
{"input": "The analysis of two distinct mitogen-activated protein kinase pathways shows that stress-activated protein kinase-Jun N-terminal kinase activation, resulting in the phosphorylation of ATF-2, c-Jun, and JunD, is required not only for the IL-1-but also for the TPA-dependent induction, while the extracellular signal-related kinase 1 (ERK-1) and ERK-2 activation is involved in the TPA-but not in the IL-1-dependent stimulation of the uPA enhancer.", "output": {"entities": {"gene": [{"text": "mitogen-activated protein kinase", "start": 29, "end": 61}, {"text": "stress-activated protein kinase", "start": 82, "end": 113}, {"text": "Jun N-terminal kinase", "start": 114, "end": 135}, {"text": "ATF-2", "start": 184, "end": 189}, {"text": "c-Jun", "start": 191, "end": 196}, {"text": "JunD", "start": 202, "end": 206}, {"text": "IL-1", "start": 237, "end": 241}, {"text": "extracellular signal-related kinase 1", "start": 294, "end": 331}, {"text": "ERK-1", "start": 333, "end": 338}, {"text": "ERK-2", "start": 344, "end": 349}, {"text": "IL-1", "start": 399, "end": 403}, {"text": "uPA enhancer", "start": 433, "end": 445}]}}, "schema": []}
{"input": "CONCLUSIONS: In healthy individuals, whole body insulin sensitivity is related, or \" coupled, \" to the anaerobic threshold.", "output": {"entities": {"gene": [{"text": "insulin", "start": 48, "end": 55}]}}, "schema": []}
{"input": "Interdomain signaling in a two-domain fragment of the human glucocorticoid receptor.", "output": {"entities": {"gene": [{"text": "human glucocorticoid receptor", "start": 54, "end": 83}]}}, "schema": []}
{"input": "In contrast, the xtRNA (Sec) gene needs the binding of the seven Staf zinc fingers, but not Oct-1, for optimal transcriptional capacity.", "output": {"entities": {"gene": [{"text": "xtRNA", "start": 17, "end": 22}, {"text": "Sec", "start": 24, "end": 27}, {"text": "Staf zinc fingers", "start": 65, "end": 82}, {"text": "Oct-1", "start": 92, "end": 97}]}}, "schema": []}
{"input": "Collectively, these results show that the differential utilization of Staf zinc finger 1 represents a new, critical determinant of the transcriptional activation mechanism for the Xenopus tRNA (Sec) and human U6 snRNA genes.", "output": {"entities": {"gene": [{"text": "Staf zinc finger 1", "start": 70, "end": 88}, {"text": "Xenopus tRNA", "start": 180, "end": 192}, {"text": "Sec", "start": 194, "end": 197}, {"text": "human U6 snRNA genes", "start": 203, "end": 223}]}}, "schema": []}
{"input": "In B cells, HEF1 is phosphorylated by a cytoskeleton-dependent mechanism that is triggered by integrin ligation.", "output": {"entities": {"gene": [{"text": "HEF1", "start": 12, "end": 16}, {"text": "integrin", "start": 94, "end": 102}]}}, "schema": []}
{"input": "The calcitonin-induced tyrosine phosphorylation of HEF1 increased in a time-and dose-dependent manner.", "output": {"entities": {"gene": [{"text": "calcitonin", "start": 4, "end": 14}, {"text": "HEF1", "start": 51, "end": 55}]}}, "schema": []}
{"input": "Independent protrudor muscle stimulation increased VI, max (peak increase 61%, P < 0. 05), did not change Pcrit, and decreased Rn (peak decrease of 41%, P < 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "The human RAD30B and mouse Rad30b mRNA transcripts, like many repair proteins, are highly expressed in the testis.", "output": {"entities": {"gene": [{"text": "human RAD30B", "start": 4, "end": 16}, {"text": "mouse Rad30b mRNA transcripts", "start": 21, "end": 50}]}}, "schema": []}
{"input": "Analysis of the mouse STAP gene isolated from the genomic library revealed that the STAP gene spans a region of over 11 kb and comprises eight exons.", "output": {"entities": {"gene": [{"text": "mouse STAP gene", "start": 16, "end": 31}, {"text": "STAP gene", "start": 84, "end": 93}]}}, "schema": []}
{"input": "A reduced matrix distribution and enhanced cell density were observed as the biofilm aged.", "output": {"entities": {}}, "schema": []}
{"input": "After 10 months of treatment with the conjugated estrogen, both his height and weight showed improvement, while his bone mineral density and bone age were increased.", "output": {"entities": {}}, "schema": []}
{"input": "Viscosity experiments on the catalytic fragment kinase reaction demonstrated that the chemical (phosphoryl transfer) step had a reduced rate.", "output": {"entities": {}}, "schema": []}
{"input": "Velocity sedimentation, cross-linking, and immunoprecipitation analyses of detergent-solubilized rat brain revealed that the 32 and 34 kDa polypeptides reside within heterotetramers.", "output": {"entities": {}}, "schema": []}
{"input": "In vitro expression levels of the different plasmids differed by as much as tenfold.", "output": {"entities": {}}, "schema": []}
{"input": "In EEG only single slow waves above left temporal region were revealed.", "output": {"entities": {}}, "schema": []}
{"input": "Molecular characterization of type-specific capsular polysaccharide biosynthesis genes of Streptococcus agalactiae type Ia.", "output": {"entities": {}}, "schema": []}
{"input": "(1998) FASEB J.", "output": {"entities": {}}, "schema": []}
{"input": "IL-1beta (10 ng/ml) drastically increased both PDGFalphaR and CCAAT/enhancer-binding protein delta (C/EBPdelta) mRNA levels in a time dependent manner.", "output": {"entities": {"gene": [{"text": "IL-1beta", "start": 0, "end": 8}, {"text": "PDGFalphaR", "start": 47, "end": 57}, {"text": "CCAAT/enhancer-binding protein delta", "start": 62, "end": 98}, {"text": "C/EBPdelta", "start": 100, "end": 110}]}}, "schema": []}
{"input": "Transient tyrosine phosphorylation of Crk in fibroblast growth factor-2-stimulated endothelial cells was dependent on the juxtamembrane tyrosine residue 463 in FGFR-1, and a Crk SH2 domain precipitated FGFR-1 via phosphorylated Tyr-463, indicating direct complex formation between Crk and FGFR-1.", "output": {"entities": {"gene": [{"text": "Crk", "start": 38, "end": 41}, {"text": "fibroblast growth factor-2", "start": 45, "end": 71}, {"text": "FGFR-1", "start": 160, "end": 166}, {"text": "Crk SH2 domain", "start": 174, "end": 188}, {"text": "FGFR-1", "start": 202, "end": 208}, {"text": "Crk", "start": 281, "end": 284}, {"text": "FGFR-1", "start": 289, "end": 295}]}}, "schema": []}
{"input": "Role of the 3' untranslated region of baculovirus p10 mRNA in high-level expression of foreign genes.", "output": {"entities": {"gene": [{"text": "baculovirus p10 mRNA", "start": 38, "end": 58}]}}, "schema": []}
{"input": "The intron RNA consists of 2492 nucleotides which can be folded into a secondary structure with all the expected sequence motifs of subgroup-IIA1 introns (Michel et al.", "output": {"entities": {}}, "schema": []}
{"input": "The intron is capable of splicing despite the fact that both the EBS1/IBS1 and the EBS2/IBS2 sequence motifs, thought to be necessary for correct splicing, extend over 5 instead of 6 bp.", "output": {"entities": {"gene": [{"text": "EBS1", "start": 65, "end": 69}, {"text": "IBS1", "start": 70, "end": 74}, {"text": "EBS2", "start": 83, "end": 87}, {"text": "IBS2", "start": 88, "end": 92}]}}, "schema": []}
{"input": "The Trk/Nerve Growth Factor receptor mediates the rapid activation of a number of intracellular signaling proteins, including phosphatidylinositol 3-kinase (PI 3-kinase).", "output": {"entities": {"gene": [{"text": "Trk/Nerve Growth Factor receptor", "start": 4, "end": 36}, {"text": "phosphatidylinositol 3-kinase", "start": 126, "end": 155}, {"text": "PI 3-kinase", "start": 157, "end": 168}]}}, "schema": []}
{"input": "Chemical uptake into human stratum corneum in vivo from volatile and non-volatile solvents.", "output": {"entities": {}}, "schema": []}
{"input": "Like DNA binding, transcriptional enhancement required amino-terminally located basic amino acid residues but not the carboxyl-terminal portion of Hap46 known to participate in hsp70 interaction.", "output": {"entities": {"gene": [{"text": "Hap46", "start": 147, "end": 152}, {"text": "hsp70", "start": 177, "end": 182}]}}, "schema": []}
{"input": "We have tested the function of two potential NF-kappaB-like sites present in the PAI-2 proximal promoter for responsiveness to TNFalpha using chloramphenicol acetyl transferase reporter gene deletion and mutation analyses.", "output": {"entities": {"gene": [{"text": "NF-kappaB-like sites", "start": 45, "end": 65}, {"text": "PAI-2 proximal promoter", "start": 81, "end": 104}, {"text": "TNFalpha", "start": 127, "end": 135}, {"text": "chloramphenicol acetyl transferase reporter gene", "start": 142, "end": 190}]}}, "schema": []}
{"input": "N-terminal sequence analysis and NMR measurements revealed that this fragment originates from the C-terminal 80 residues of MBF1 and form a well structured C-terminal domain of MBF1, MBF1CTD.", "output": {"entities": {"gene": [{"text": "MBF1", "start": 124, "end": 128}, {"text": "MBF1", "start": 177, "end": 181}, {"text": "MBF1CTD", "start": 183, "end": 190}]}}, "schema": []}
{"input": "The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase.", "output": {"entities": {"gene": [{"text": "immediate-early gene", "start": 41, "end": 61}, {"text": "MAP kinase cascades", "start": 100, "end": 119}, {"text": "MSK1", "start": 121, "end": 125}, {"text": "histone H3", "start": 141, "end": 151}, {"text": "HMG-14", "start": 152, "end": 158}]}}, "schema": []}
{"input": "272, 1904].", "output": {"entities": {}}, "schema": []}
{"input": "Using 16 strains of C. trachomatis in triplicate assays, we found the RT-PCR method consistently more sensitive than the conventional technique for all eight antimicrobials tested, with resultant MICs determined by RT-PCR ranging from 1. 6-fold higher (erythromycin) to >/= 195-fold higher (amoxicillin).", "output": {"entities": {}}, "schema": []}
{"input": "Recent molecular analysis has revealed that the S locus is highly polymorphic and contains several genes, i. e., SLG, SRK, the as-yet-unidentified pollen S gene (s), and other linked genes.", "output": {"entities": {"gene": [{"text": "S locus", "start": 48, "end": 55}, {"text": "SLG", "start": 113, "end": 116}, {"text": "SRK", "start": 118, "end": 121}, {"text": "pollen S gene (s)", "start": 147, "end": 164}]}}, "schema": []}
{"input": "A cDNA encoding a putative RNA and/or DNA helicase has been isolated from Arabidopsis thaliana cDNA libraries.", "output": {"entities": {"gene": [{"text": "RNA and/or DNA helicase", "start": 27, "end": 50}]}}, "schema": []}
{"input": "In vivo, MyoD requires this tryptophan motif to evoke chromatin remodeling in the Myogenin promoter and to activate Myogenin transcription.", "output": {"entities": {"gene": [{"text": "MyoD", "start": 9, "end": 13}, {"text": "Myogenin promoter", "start": 82, "end": 99}, {"text": "Myogenin", "start": 116, "end": 124}]}}, "schema": []}
{"input": "Feed intake and BW gains were decreased (P < 0. 05) by dietary treatments containing M.", "output": {"entities": {}}, "schema": []}
{"input": "The N terminus of beta (95 kDa) corresponds to alpha with the integrase domain attached to the C terminus (32 kDa).", "output": {"entities": {"gene": [{"text": "integrase domain", "start": 62, "end": 78}]}}, "schema": []}
{"input": "Skn-1a lacking the C-terminal region completely lost transactivation ability, irrespective of the promoter tested, and was able to block transactivation by normal Skn-1a in competition assays.", "output": {"entities": {"gene": [{"text": "Skn-1a", "start": 0, "end": 6}, {"text": "Skn-1a", "start": 163, "end": 169}]}}, "schema": []}
{"input": "In early Xenopus embryos, the transforming growth factor-beta member activin induces the gene Mix. 2 by stimulating the formation of a multiprotein complex, activin-responsive factor (ARF).", "output": {"entities": {"gene": [{"text": "transforming growth factor-beta", "start": 30, "end": 61}, {"text": "activin", "start": 69, "end": 76}, {"text": "gene Mix. 2", "start": 89, "end": 100}, {"text": "activin-responsive factor", "start": 157, "end": 182}, {"text": "ARF", "start": 184, "end": 187}]}}, "schema": []}
{"input": "To further characterize the structure and evolutionary synthesis of the CMT1A-REP repeat, fluorescent in situ hybridization (FISH) analysis and heterologous PCR-based assays were carried out for a series of primates.", "output": {"entities": {}}, "schema": []}
{"input": "Natl.", "output": {"entities": {}}, "schema": []}
{"input": "In the face of the outbreak, there was a delay before vaccination was able to stop deaths.", "output": {"entities": {}}, "schema": []}
{"input": "Here we show that a novel isoform of Rapl GTPase-activating protein, called rap1GAPII, binds specifically to the alpha-subunits of the G (i) family of heterotrimeric G-proteins.", "output": {"entities": {"gene": [{"text": "Rapl GTPase-activating protein", "start": 37, "end": 67}, {"text": "rap1GAPII", "start": 76, "end": 85}, {"text": "G (i) family", "start": 135, "end": 147}, {"text": "heterotrimeric G-proteins", "start": 151, "end": 176}]}}, "schema": []}
{"input": "The B-oligomer of pertussis toxin deactivates CC chemokine receptor 5 and blocks entry of M-tropic HIV-1 strains.", "output": {"entities": {"gene": [{"text": "pertussis toxin", "start": 18, "end": 33}, {"text": "CC chemokine receptor 5", "start": 46, "end": 69}]}}, "schema": []}
{"input": "Cross-linking the B cell Ag receptor (BCR) to surface Fc receptors for IgG (Fc gamma R) inhibits G1-to-S progression; the mechanism by which this occurs is not completely known.", "output": {"entities": {"gene": [{"text": "B cell Ag receptor", "start": 18, "end": 36}, {"text": "BCR", "start": 38, "end": 41}, {"text": "surface Fc receptors", "start": 46, "end": 66}, {"text": "IgG", "start": 71, "end": 74}, {"text": "Fc gamma R", "start": 76, "end": 86}]}}, "schema": []}
{"input": "Cross-linking the B cell Ag receptor (BCR) to surface Fc receptors for IgG (Fc gamma R) inhibits G1-to-S progression; the mechanism by which this occurs is not completely known.", "output": {"entities": {"gene": [{"text": "B cell Ag receptor", "start": 18, "end": 36}, {"text": "BCR", "start": 38, "end": 41}, {"text": "surface Fc receptors", "start": 46, "end": 66}, {"text": "IgG", "start": 71, "end": 74}, {"text": "Fc gamma R", "start": 76, "end": 86}]}}, "schema": []}
{"input": "TRAF2 is a potent activator of a 95-kDa serine/threonine kinase termed germinal center kinase related (GCKR, also referred to as KHS1), which signals activation of the SAPK pathway.", "output": {"entities": {"gene": [{"text": "TRAF2", "start": 0, "end": 5}, {"text": "95-kDa serine/threonine kinase", "start": 33, "end": 63}, {"text": "germinal center kinase related", "start": 71, "end": 101}, {"text": "GCKR", "start": 103, "end": 107}, {"text": "KHS1", "start": 129, "end": 133}, {"text": "SAPK", "start": 168, "end": 172}]}}, "schema": []}
{"input": "An activation-responsive element in single C motif-1/lymphotactin promoter is a site of constitutive and inducible DNA-protein interactions involving nuclear factor of activated T cell.", "output": {"entities": {"gene": [{"text": "single C motif-1", "start": 36, "end": 52}, {"text": "lymphotactin", "start": 53, "end": 65}]}}, "schema": []}
{"input": "A portion of p193 is nuclear and localizes to the mitotic spindle.", "output": {"entities": {"gene": [{"text": "p193", "start": 13, "end": 17}]}}, "schema": []}
{"input": "The main issues are the need to explain a number of still unknown mechanisms, to determine which \" natural diet \" carries the minimum coronary risk and whether \" new \" foods produced by modern technology are really needed to contrast this epidemic.", "output": {"entities": {}}, "schema": []}
{"input": "Cotransfection of the coactivator CREB-binding protein relieved the transcriptional repression of PPARalphawt by PPARalphatr, suggesting that the dominant negative effect of PPARalphatr might occur through competition for essential coactivators.", "output": {"entities": {"gene": [{"text": "CREB-binding protein", "start": 34, "end": 54}, {"text": "PPARalphawt", "start": 98, "end": 109}, {"text": "PPARalphatr", "start": 113, "end": 124}, {"text": "PPARalphatr", "start": 174, "end": 185}]}}, "schema": []}
{"input": "SF-1 does not have an N-terminal AF1 domain.", "output": {"entities": {"gene": [{"text": "SF-1", "start": 0, "end": 4}]}}, "schema": []}
{"input": "We discuss these results in terms of the influence that time and nutritional constraints have on odonate development patterns and fitness.", "output": {"entities": {}}, "schema": []}
{"input": "OBJECTIVE: 1998 Surveillance, Epidemiology, and End Results (SEER) data estimate an 83. 1% 5-year survival rate for corpus uteri adenocarcinoma FIGO stage II.", "output": {"entities": {}}, "schema": []}
{"input": "A novel Drosophila A kinase anchor protein, Drosophila A kinase anchor protein 200 (DAKAP200), is predicted to be involved in routing, mediating, and integrating signals carried by cAMP, Ca (2 +), and diacylglycerol (Li, Z., Rossi, E.", "output": {"entities": {"gene": [{"text": "Drosophila A kinase anchor protein", "start": 8, "end": 42}, {"text": "Drosophila A kinase anchor protein 200", "start": 44, "end": 82}, {"text": "DAKAP200", "start": 84, "end": 92}]}}, "schema": []}
{"input": "In vitro transcription results indicate that this 5' structure functions in the attenuation mechanism, since deletion of the stem-loop caused an increase in transcription readthrough.", "output": {"entities": {}}, "schema": []}
{"input": "A 5' RNA stem-loop participates in the transcription attenuation mechanism that controls expression of the Bacillus subtilis trpEDCFBA operon.", "output": {"entities": {"gene": [{"text": "Bacillus subtilis trpEDCFBA operon", "start": 107, "end": 141}]}}, "schema": []}
{"input": "Single-alanine-substitution mutations had minimal, if any, effects on S-induced cell-to-cell fusion.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, we demonstrate that transcription from the MMTV 5' LTR is highly active in the absence of Stat5a, a transcription factor that had been shown previously to be required for transcription from the MMTV LTR.", "output": {"entities": {"gene": [{"text": "MMTV 5' LTR", "start": 56, "end": 67}, {"text": "Stat5a", "start": 103, "end": 109}, {"text": "MMTV LTR", "start": 207, "end": 215}]}}, "schema": []}
{"input": "Regional insertional mutagenesis of specific genes on the CIC5F11/CIC2B9 locus of Arabidopsis thaliana chromosome 5 using the Ac/Ds transposon in combination with the cDNA scanning method.", "output": {"entities": {"gene": [{"text": "CIC5F11", "start": 58, "end": 65}, {"text": "CIC2B9", "start": 66, "end": 72}, {"text": "Ac", "start": 126, "end": 128}, {"text": "Ds", "start": 129, "end": 131}]}}, "schema": []}
{"input": "RESULTS: CK-MB elevation was detected in 313 patients (18. 7%), with 1-3x in 12. 8%, 3-5x in 3. 5% and > 5x normal in 2. 4% of patients.", "output": {"entities": {"gene": [{"text": "CK", "start": 9, "end": 11}, {"text": "MB", "start": 12, "end": 14}]}}, "schema": []}
{"input": "Thus, NART-R performance may not be a valid estimate of baseline IQ for patients with neurologic disorders with suspected language impairment.", "output": {"entities": {}}, "schema": []}
{"input": "Activated areas have been identified by means of cross-correlation analysis.", "output": {"entities": {}}, "schema": []}
{"input": "Natural Haemophilus influenzae type b capsular polysaccharide antibodies in 412 infants and children from West Africa (Burkina-Faso) and France: a cross-sectional serosurvey.", "output": {"entities": {}}, "schema": []}
{"input": "In this study, we identified Sp1 and Sp3 as major factors binding to the Sp1 sites of the p21/WAF1/Cip1 promoter in MG63 cells through electrophoretic mobility shift assays and showed that TSA treatment did not change their binding activities.", "output": {"entities": {"gene": [{"text": "Sp1", "start": 29, "end": 32}, {"text": "Sp3", "start": 37, "end": 40}, {"text": "Sp1 sites", "start": 73, "end": 82}, {"text": "p21", "start": 90, "end": 93}, {"text": "WAF1", "start": 94, "end": 98}, {"text": "Cip1", "start": 99, "end": 103}]}}, "schema": []}
{"input": "Galoyan has summarized the results of his discovery of cardioactive neurohormones.", "output": {"entities": {}}, "schema": []}
{"input": "To study the regulation of its expression, the human aldehyde reductase gene and promoter were cloned and characterized.", "output": {"entities": {"gene": [{"text": "human aldehyde reductase gene", "start": 47, "end": 76}]}}, "schema": []}
{"input": "The C2C-Prx is encoded as a preprotein of 273 amino acids containing a putative chloroplast-targeting signal of 65 amino acids at its N-terminus.", "output": {"entities": {"gene": [{"text": "C2C", "start": 4, "end": 7}, {"text": "Prx", "start": 8, "end": 11}]}}, "schema": []}
{"input": "Immediately before surgery patients received either intravenous hydrocortisone 100 mg or placebo in random, double-blind order.", "output": {"entities": {}}, "schema": []}
{"input": "A tyrosine-based sorting signal in the beta2 integrin cytoplasmic domain mediates its recycling to the plasma membrane and is required for ligand-supported migration.", "output": {"entities": {"gene": [{"text": "beta2 integrin cytoplasmic domain", "start": 39, "end": 72}]}}, "schema": []}
{"input": "The injection of XDRP1 protein into fertilized Xenopus eggs blocked embryonic cell division.", "output": {"entities": {"gene": [{"text": "XDRP1 protein", "start": 17, "end": 30}]}}, "schema": []}
{"input": "Using transgenic Xenopus embryos, we demonstrate that the integrity of these two sequences is necessary for correct spatial expression of a Xbra2 promoter-driven reporter gene.", "output": {"entities": {"gene": [{"text": "Xbra2 promoter-driven reporter gene", "start": 140, "end": 175}]}}, "schema": []}
{"input": "In order to screen for such cofactors, we have used a transcriptionally inactive mutant of Xenopus MEF2D in a yeast two-hybrid screen.", "output": {"entities": {"gene": [{"text": "Xenopus MEF2D", "start": 91, "end": 104}]}}, "schema": []}
{"input": "NuA4 has an apparent molecular mass of 1. 3 MDa.", "output": {"entities": {"gene": [{"text": "NuA4", "start": 0, "end": 4}]}}, "schema": []}
{"input": "ATF1 transcription is negatively regulated by unsaturated fatty acids and oxygen.", "output": {"entities": {"gene": [{"text": "ATF1", "start": 0, "end": 4}]}}, "schema": []}
{"input": "Mutation of TTF-1-binding sites (TBE) 1, 3, and 4 in combination markedly decreased transcriptional activity of SP-A promoter-chloramphenicol acetyltransferase constructs containing SP-A gene sequences from-256 to + 45.", "output": {"entities": {"gene": [{"text": "TTF-1-binding sites (TBE) 1, 3, and 4", "start": 12, "end": 49}, {"text": "SP-A", "start": 112, "end": 116}, {"text": "chloramphenicol acetyltransferase", "start": 126, "end": 159}, {"text": "SP-A gene", "start": 182, "end": 191}]}}, "schema": []}
{"input": "Insulin-like growth factor-I induces bcl-2 promoter through the transcription factor cAMP-response element-binding protein.", "output": {"entities": {"gene": [{"text": "Insulin-like growth factor-I", "start": 0, "end": 28}, {"text": "bcl-2 promoter", "start": 37, "end": 51}, {"text": "cAMP-response element-binding protein", "start": 85, "end": 122}]}}, "schema": []}
{"input": "Synthesis of antisense RNA and S phase-dependent binding of E2F complexes in intron 1.", "output": {"entities": {"gene": [{"text": "E2F complexes", "start": 60, "end": 73}]}}, "schema": []}
{"input": "Identification of eotaxin-3 will further promote our understanding of the control of eosinophil trafficking and other CCR3-mediated biological phenomena.", "output": {"entities": {"gene": [{"text": "eotaxin-3", "start": 18, "end": 27}, {"text": "CCR3", "start": 118, "end": 122}]}}, "schema": []}
{"input": "NF-kappaB plays a critical role in activation of HIV-1 gene expression by cytokines and other stimuli, but the signal transduction pathways that regulate the switch from latent to productive infection have not been defined.", "output": {"entities": {"gene": [{"text": "NF-kappaB", "start": 0, "end": 9}]}}, "schema": []}
{"input": "These studies suggest that MAPK acts by stimulating AP-1 and a subsequent physical and functional interaction of AP-1 with NF-kappaB, resulting in a complex that synergistically transactivates the HIV-1 LTR.", "output": {"entities": {"gene": [{"text": "MAPK", "start": 27, "end": 31}, {"text": "AP-1", "start": 52, "end": 56}, {"text": "AP-1", "start": 113, "end": 117}, {"text": "NF-kappaB", "start": 123, "end": 132}, {"text": "HIV-1 LTR", "start": 197, "end": 206}]}}, "schema": []}
{"input": "ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB.", "output": {"entities": {"gene": [{"text": "ERK MAP kinase", "start": 0, "end": 14}, {"text": "AP-1", "start": 122, "end": 126}, {"text": "NF-kappaB", "start": 131, "end": 140}]}}, "schema": []}
{"input": "A human nuclear-localized chaperone that regulates dimerization, DNA binding, and transcriptional activity of bZIP proteins.", "output": {"entities": {"gene": [{"text": "bZIP proteins", "start": 110, "end": 123}]}}, "schema": []}
{"input": "Clinical differentiation of patients with mild diplegic cerebral palsy (CP) and idiopathic toe walking (ITW) can be difficult.", "output": {"entities": {}}, "schema": []}
{"input": "Sputum IL-8 and MPO were significantly increased after BPT in both TDI-and grain dust-asthma (P < 0. 05).", "output": {"entities": {"gene": [{"text": "Sputum IL-8", "start": 0, "end": 11}, {"text": "MPO", "start": 16, "end": 19}]}}, "schema": []}
{"input": "Montelukast reduces airway eosinophilic inflammation in asthma: a randomized, controlled trial.", "output": {"entities": {}}, "schema": []}
{"input": "Here, we demonstrate that kinase-dead but not wild-type forms of Fyn, Lck, and ZAP-70 block 70Z Cbl-mediated NFAT activation.", "output": {"entities": {"gene": [{"text": "Fyn", "start": 65, "end": 68}, {"text": "Lck", "start": 70, "end": 73}, {"text": "ZAP-70", "start": 79, "end": 85}, {"text": "Cbl", "start": 96, "end": 99}, {"text": "NFAT", "start": 109, "end": 113}]}}, "schema": []}
{"input": "Substitutions of region I with synthetic sequences showed that no specific sequence but rather repeats of three or more consecutive adenines or thymines, without interruption by guanine or cytosine, are required for the ARS activity.", "output": {"entities": {}}, "schema": []}
{"input": "In Saccharomyces cerevisiae, PHO85 encodes a cyclin-dependent protein kinase (Cdk) catalytic subunit with multiple regulatory roles thought to be specified by association with different cyclin partners (Pcls).", "output": {"entities": {"gene": [{"text": "PHO85", "start": 29, "end": 34}, {"text": "cyclin-dependent protein kinase", "start": 45, "end": 76}, {"text": "Cdk", "start": 78, "end": 81}, {"text": "cyclin", "start": 186, "end": 192}, {"text": "Pcls", "start": 203, "end": 207}]}}, "schema": []}
{"input": "Mutants with mild lace alleles grow to become adults with multiple aberrant morphologies in the appendages, compound eye, and bristles.", "output": {"entities": {"gene": [{"text": "lace alleles", "start": 18, "end": 30}]}}, "schema": []}
{"input": "In fact, SPT activity in the fly expressing epitope-tagged Lace was absorbed by epitope-specific antibody.", "output": {"entities": {"gene": [{"text": "SPT", "start": 9, "end": 12}, {"text": "Lace", "start": 59, "end": 63}]}}, "schema": []}
{"input": "These results show that targeting of Ras-GAP could represent a novel anticancer approach.", "output": {"entities": {"gene": [{"text": "Ras", "start": 37, "end": 40}, {"text": "GAP", "start": 41, "end": 44}]}}, "schema": []}
{"input": "EB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t (1; 19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1.", "output": {"entities": {"gene": [{"text": "EB-1", "start": 0, "end": 4}, {"text": "tyrosine kinase signal transduction gene", "start": 8, "end": 48}, {"text": "E2a", "start": 145, "end": 148}, {"text": "Pbx1", "start": 149, "end": 153}]}}, "schema": []}
{"input": "BCL6 encodes a POZ/Zn finger protein, a structure similar to that of many Drosophila developmental regulators and to another protein involved in a human hematopoietic malignancy, PLZF.", "output": {"entities": {"gene": [{"text": "BCL6", "start": 0, "end": 4}, {"text": "POZ/Zn finger protein", "start": 15, "end": 36}, {"text": "PLZF", "start": 179, "end": 183}]}}, "schema": []}
{"input": "Beta 1 integrin-and proteoglycan-mediated stimulation of T lymphoma cell adhesion and mitogen-activated protein kinase signaling by thrombospondin-1 and thrombospondin-1 peptides.", "output": {"entities": {"gene": [{"text": "Beta 1 integrin", "start": 0, "end": 15}, {"text": "mitogen-activated protein kinase", "start": 86, "end": 118}, {"text": "thrombospondin-1", "start": 132, "end": 148}, {"text": "thrombospondin-1 peptides", "start": 153, "end": 178}]}}, "schema": []}
{"input": "Optical CD, and spectral and activity analyses were used to examine reactivity of HO isozymes with NO species produced by NO donors.", "output": {"entities": {"gene": [{"text": "HO isozymes", "start": 82, "end": 93}]}}, "schema": []}
{"input": "The phosphotransferase system (PTS) of Streptomyces coelicolor identification and biochemical analysis of a histidine phosphocarrier protein HPr encoded by the gene ptsH.", "output": {"entities": {"gene": [{"text": "histidine phosphocarrier protein HPr", "start": 108, "end": 144}, {"text": "ptsH", "start": 165, "end": 169}]}}, "schema": []}
{"input": "Serum concentrations of bone specific alkaline phosphatase (BALP) and osteocalcin (bone Gla protein, BGP), urinary levels of pyridinoline (Pyr) and deoxypyridinoline (Dpyr) and computed tomography (CT) measurements of the cross-sectional areas of the vertebrae and the femurs, the apparent density of cancellous bone in the vertebrae, and the volume and the material density of cortical bone in the femurs were determined in 126 boys and 143 girls, ages 7-18 years.", "output": {"entities": {"gene": [{"text": "bone specific alkaline phosphatase", "start": 24, "end": 58}, {"text": "BALP", "start": 60, "end": 64}, {"text": "osteocalcin", "start": 70, "end": 81}, {"text": "bone Gla protein", "start": 83, "end": 99}, {"text": "BGP", "start": 101, "end": 104}]}}, "schema": []}
{"input": "In another study, intravenous administration of devazepide, a specific cholecystokinin-A receptor antagonist, at a dose of 0. 1 mg/kg/hr was begun 15 min before postprandial saline intake and continued for 1 hr.", "output": {"entities": {"gene": [{"text": "cholecystokinin-A receptor", "start": 71, "end": 97}]}}, "schema": []}
{"input": "This cluster consisted of four apparently unrelated ESTs and two genes, pregnancy-associated plasma protein-A (PAPP-A) and a novel gene (tentatively named EST-YD1).", "output": {"entities": {"gene": [{"text": "pregnancy-associated plasma protein-A", "start": 72, "end": 109}, {"text": "PAPP-A", "start": 111, "end": 117}, {"text": "EST-YD1", "start": 155, "end": 162}]}}, "schema": []}
{"input": "Prognostic value of a treadmill exercise score in symptomatic patients with nonspecific ST-T abnormalities on resting ECG.", "output": {"entities": {}}, "schema": []}
{"input": "Structural changes in the C-terminus of Ca2 +-bound rat S100B (beta beta) upon binding to a peptide derived from the C-terminal regulatory domain of p53.", "output": {"entities": {"gene": [{"text": "rat S100B", "start": 52, "end": 61}, {"text": "beta beta", "start": 63, "end": 72}, {"text": "p53", "start": 149, "end": 152}]}}, "schema": []}
{"input": "We propose that Gly84 is part of a putative \" oxyanion hole \" involved in the stabilization of the transition state similar to the C group of the esterase/lipase family.", "output": {"entities": {"gene": [{"text": "C group", "start": 131, "end": 138}, {"text": "esterase", "start": 146, "end": 154}, {"text": "lipase", "start": 155, "end": 161}]}}, "schema": []}
{"input": "The solution structure of the adduct derived from the covalent bonding of the fjord region (+)-(11S, 12R, 13R, 14S) stereoisomer of anti-11, 12-dihydroxy-13, 14-epoxy-11, 12, 13, 14-tetrahydrobenzo [g] chrysene, (+)-anti-B [g] CDE, to the exocyclic N (6) amino group of the adenine residue dA6, (designated (+)-trans-anti-(B [g] C) dA6), positioned opposite a thymine residue dT17 in the DNA sequence context d (C1-T2-C3-T4-C5-(B [g] C) A6-C7-T8-T9-C10-C11). d (G12-G13-A14-A15-G16-T17-G18-A19-G20 + + +-A21-G22) (designated (B [g] C) dA. dT 11-mer duplex), has been studied using structural information derived from NMR data in combination with molecular dynamics (MD) calculations.", "output": {"entities": {}}, "schema": []}
{"input": "Since sildenafil came on the market, it seems that the place of MUSE is reduced because comparative studies give better results for sildenafil than MUSE (70% vs 40%) and of course with a better acceptance.", "output": {"entities": {}}, "schema": []}
{"input": "Serum antibodies were detected in at least 95% of the infected guinea pigs between 4-30 WPI and rats between 3-16 WPI.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS: These results show that once daily oral valganciclovir can produce exposures of ganciclovir (AUC24) exceeding those attained using intravenous ganciclovir 10 mg/kg.", "output": {"entities": {}}, "schema": []}
{"input": "Except for nonperfusion of neurosensory retinal vessels at a light dose of 150 J/cm2, no other adverse events were of concern.", "output": {"entities": {}}, "schema": []}
{"input": "Except for nonperfusion of neurosensory retinal vessels at a light dose of 150 J/cm2, no other adverse events were of concern.", "output": {"entities": {}}, "schema": []}
{"input": "The healing rate in HIV-positive patients was 66 percent after 14 weeks and 100 percent after 32 weeks; the corresponding figures for patients with acquired immunodeficiency syndrome were 0 and 50 percent.", "output": {"entities": {}}, "schema": []}
{"input": "The P mRNA also contains a third ORF for the V protein, although it is unclear how or whether this ORF is accessed.", "output": {"entities": {"gene": [{"text": "P mRNA", "start": 4, "end": 10}, {"text": "V protein", "start": 45, "end": 54}]}}, "schema": []}
{"input": "A genetic screen in yeast has allowed us to identify a novel transcriptional factor binding to the GlRE, i. e. the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII).", "output": {"entities": {"gene": [{"text": "chicken ovalbumin upstream promoter-transcription factor II", "start": 115, "end": 174}, {"text": "COUP-TFII", "start": 176, "end": 185}]}}, "schema": []}
{"input": "We have cloned the single-copy gene for the trans-spliceosomal U5 snRNA from the trypanosomatid species Leptomonas seymouri, using U5 RNA affinity selection and cDNA cloning.", "output": {"entities": {"gene": [{"text": "trans-spliceosomal U5 snRNA", "start": 44, "end": 71}, {"text": "U5 RNA", "start": 131, "end": 137}]}}, "schema": []}
{"input": "The MMPI-A (Butcher et al., 1992), like the older MMPI (Hathaway & McKinley, 1983), distinguishes between anorexia and bulimia.", "output": {"entities": {}}, "schema": []}
{"input": "On the other hand, phosphatidyl inositol 4, 5 bisphosphate (PIP2) hydrolysis requires direct phosphorylation at tyrosine residue of the PLC-gamma1 isozyme.", "output": {"entities": {"gene": [{"text": "PLC-gamma1 isozyme", "start": 136, "end": 154}]}}, "schema": []}
{"input": "A G22V mutant of M-Ras was constitutively active and its expression in an interleukin-3 (IL-3)-dependent mast cell/megakaryocyte cell line resulted in increased survival in the absence of IL-3, increased growth in IL-4, and, at high expression levels, in factor-independent growth.", "output": {"entities": {"gene": [{"text": "G22V mutant", "start": 2, "end": 13}, {"text": "M-Ras", "start": 17, "end": 22}, {"text": "interleukin-3", "start": 74, "end": 87}, {"text": "IL-3", "start": 89, "end": 93}, {"text": "IL-3", "start": 188, "end": 192}, {"text": "IL-4", "start": 214, "end": 218}]}}, "schema": []}
{"input": "Mammalian M-Ras and a Caenorhabditis elegans orthologue exhibit conserved structural features, and these are likely to mediate activation of distinctive signaling paths that function in parallel to those downstream of p21 Ras.", "output": {"entities": {"gene": [{"text": "Mammalian M-Ras", "start": 0, "end": 15}, {"text": "p21 Ras", "start": 218, "end": 225}]}}, "schema": []}
{"input": "Taken together, our data suggest that PecS attenuates pelD and pelE expression rather than acting as a true repressor like KdgR.", "output": {"entities": {"gene": [{"text": "PecS", "start": 38, "end": 42}, {"text": "pelD", "start": 54, "end": 58}, {"text": "pelE", "start": 63, "end": 67}, {"text": "KdgR", "start": 123, "end": 127}]}}, "schema": []}
{"input": "These observations establish that RsmC negatively regulates rsmB transcription but positively affects RsmA production.", "output": {"entities": {"gene": [{"text": "RsmC", "start": 34, "end": 38}, {"text": "rsmB", "start": 60, "end": 64}, {"text": "RsmA", "start": 102, "end": 106}]}}, "schema": []}
{"input": "All were experienced hearing aid users who wore linear Class D instruments with input compression limiting at the time of their enrollment in this study.", "output": {"entities": {}}, "schema": []}
{"input": "Ribonuclease protection assays revealed that hmg1 and hmg2 are differentially expressed in a developmentally-and spatially-modulated manner during morphogenesis of specialized terpenoid-containing pigment glands in embryos.", "output": {"entities": {"gene": [{"text": "hmg1", "start": 45, "end": 49}, {"text": "hmg2", "start": 54, "end": 58}]}}, "schema": []}
{"input": "Inactivation of the Neurospora crassa mitochondrial outer membrane protein TOM70 by repeat-induced point mutation (RIP) causes defects in mitochondrial protein import and morphology.", "output": {"entities": {"gene": [{"text": "Neurospora crassa mitochondrial outer membrane protein TOM70", "start": 20, "end": 80}]}}, "schema": []}
{"input": "Recently, cell-surface TRAIL has been shown to be expressed by activated human and mouse T lymphocytes, raising the possibility that TRAIL might be involved in T cell-mediated cytotoxicity and/or immune regulation.", "output": {"entities": {"gene": [{"text": "TRAIL", "start": 23, "end": 28}, {"text": "TRAIL", "start": 133, "end": 138}]}}, "schema": []}
{"input": "A panel of pharmacologic inhibitors was used to investigate the signal transduction pathways involved in TRAIL gene induction following T lymphocyte activation.", "output": {"entities": {"gene": [{"text": "TRAIL gene", "start": 105, "end": 115}]}}, "schema": []}
{"input": "Defective provirus genomes of human T-cell leukemia virus type I are frequently detected in lymphocytes from infected individuals and in infected cell lines.", "output": {"entities": {}}, "schema": []}
{"input": "A total of 174 primer pairs gave interpretable banding patterns, 137 (79%) of which revealed at least two alleles on native polyacrylamide gels.", "output": {"entities": {}}, "schema": []}
{"input": "A population pharmacokinetic study of cyclosporin in organ transplant patients, including elderly allograft recipients up to 75 years of age, did not identify age as a covariable influencing cyclosporin pharmacokinetics.", "output": {"entities": {}}, "schema": []}
{"input": "Immunofluoresence data indicated that once bound to the mutant receptor, fluorescent-labeled RAP co-localized with markers of the endosomal pathway, whereas, in cells expressing the wild-type receptor, RAP fluorescence co-localized with lysosomal markers.", "output": {"entities": {"gene": [{"text": "RAP", "start": 93, "end": 96}, {"text": "RAP", "start": 202, "end": 205}]}}, "schema": []}
{"input": "Interleukin-12 (IL-12) is a cytokine produced by peripheral blood mononuclear cells (PBMC) that causes interferon-gamma (IFN-gamma) production and enhancement of cell-mediated cytotoxicity.", "output": {"entities": {"gene": [{"text": "Interleukin-12", "start": 0, "end": 14}, {"text": "IL-12", "start": 16, "end": 21}, {"text": "interferon-gamma", "start": 103, "end": 119}, {"text": "IFN-gamma", "start": 121, "end": 130}]}}, "schema": []}
{"input": "IL-12 production was correlated with C3a concentration measured at the outlet of hemodialyzer after 15 min of dialysis (r = 0. 69, P < 0. 01).", "output": {"entities": {"gene": [{"text": "IL-12", "start": 0, "end": 5}]}}, "schema": []}
{"input": "In HeLa cells, the JNKK2-JNK1 fusion protein showed significant JNK activity, which was comparable with that of JNK1 activated by many stimuli and activators, including EGF, TNF-alpha, anisomycin, UV irradiation, MEKK1, and small GTP binding proteins Rac1 and Cdc42Hs.", "output": {"entities": {"gene": [{"text": "JNKK2", "start": 19, "end": 24}, {"text": "JNK1", "start": 25, "end": 29}, {"text": "JNK", "start": 64, "end": 67}, {"text": "JNK1", "start": 112, "end": 116}, {"text": "EGF", "start": 169, "end": 172}, {"text": "TNF-alpha", "start": 174, "end": 183}, {"text": "MEKK1", "start": 213, "end": 218}, {"text": "small GTP binding proteins Rac1", "start": 224, "end": 255}, {"text": "Cdc42Hs", "start": 260, "end": 267}]}}, "schema": []}
{"input": "J.", "output": {"entities": {}}, "schema": []}
{"input": "Our results implicate TGF-beta RII as a direct target of EWS-FLI1.", "output": {"entities": {"gene": [{"text": "TGF-beta RII", "start": 22, "end": 34}, {"text": "EWS", "start": 57, "end": 60}, {"text": "FLI1", "start": 61, "end": 65}]}}, "schema": []}
{"input": "The reduction in saturated fatty acids intake led to modest (but in group 1 significant) 0. 15 mmol/l (2. 5%) reduction in total serum cholesterol level.", "output": {"entities": {}}, "schema": []}
{"input": "Secondly, an ethanol repression autoregulation (ERA)/twelve-fold TA repeat (TAB) repressor element was identified within the promoter region of the GLK1 gene.", "output": {"entities": {"gene": [{"text": "GLK1 gene", "start": 148, "end": 157}]}}, "schema": []}
{"input": "A crucial transcription factor in this process is STAT6, which binds to a specific DNA element upon cytokine activation.", "output": {"entities": {"gene": [{"text": "STAT6", "start": 50, "end": 55}]}}, "schema": []}
{"input": "CONCLUSIONS: Congenital horizontal tarsal kink is rare and its cause is unknown.", "output": {"entities": {}}, "schema": []}
{"input": "A local, high-density, single-nucleotide polymorphism map used to clone Caenorhabditis elegans cdf-1.", "output": {"entities": {"gene": [{"text": "Caenorhabditis elegans cdf-1", "start": 72, "end": 100}]}}, "schema": []}
{"input": "This machinery involves a secondary structure, SECIS element, in the selenoprotein-encoding mRNA, directing selenocysteine insertion at the position of an opal (UGA) codon, normally conferring termination of translation.", "output": {"entities": {"gene": [{"text": "selenoprotein", "start": 69, "end": 82}]}}, "schema": []}
{"input": "High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA, selB and selC genes.", "output": {"entities": {"gene": [{"text": "rat thioredoxin reductase", "start": 71, "end": 96}, {"text": "selA", "start": 193, "end": 197}, {"text": "selB", "start": 199, "end": 203}, {"text": "selC genes", "start": 208, "end": 218}]}}, "schema": []}
{"input": "In Wnt signaling, beta-catenin and plakoglobin transduce signals to the nucleus through interactions with TCF-type transcription factors.", "output": {"entities": {"gene": [{"text": "Wnt", "start": 3, "end": 6}, {"text": "beta-catenin", "start": 18, "end": 30}, {"text": "plakoglobin", "start": 35, "end": 46}, {"text": "TCF-type transcription factors", "start": 106, "end": 136}]}}, "schema": []}
{"input": "Assembly of a complex between FAK and Src kinases may serve to regulate the subcellular localization and the enzymatic activity of members of the Src family of kinases.", "output": {"entities": {"gene": [{"text": "FAK", "start": 30, "end": 33}, {"text": "Src kinases", "start": 38, "end": 49}, {"text": "Src family", "start": 146, "end": 156}]}}, "schema": []}
{"input": "Our study also demonstrated significant increases in the number of larger myelinated fibers crossing the repair site in comparison with the neonatal and adult groups (p < 0. 04).", "output": {"entities": {}}, "schema": []}
{"input": "Cortical dysplasias, genetics, and epileptogenesis.", "output": {"entities": {}}, "schema": []}
{"input": "In the work reported here, we used peptide mapping, mass spectrometry, and site-directed mutagenesis to identify two sets of pAP phosphorylation sites.", "output": {"entities": {"gene": [{"text": "pAP", "start": 125, "end": 128}]}}, "schema": []}
{"input": "Both HERV-K type 1 and 2 clones were isolated.", "output": {"entities": {}}, "schema": []}
{"input": "Duch, and F.", "output": {"entities": {}}, "schema": []}
{"input": "At all time-points, most patients (>/= 87%) were receiving irbesartan/HCTZ alone.", "output": {"entities": {}}, "schema": []}
{"input": "Modification of dopamine D2 receptor activity by pergolide in Parkinson' s disease: an in vivo study by PET.", "output": {"entities": {"gene": [{"text": "dopamine D2 receptor", "start": 16, "end": 36}]}}, "schema": []}
{"input": "High-affinity binding sites for both GR and AP-1 nucleoproteins were identified at adjacent elements within the nGRE.", "output": {"entities": {"gene": [{"text": "GR", "start": 37, "end": 39}, {"text": "AP-1 nucleoproteins", "start": 44, "end": 63}]}}, "schema": []}
{"input": "When the 73-bp fragment was fused to an alpha1-globin promoter-CAT construct and cotransfected with CCAAT transcription factor 1 (CTF1)/NF1 into Drosophila Schneider SL2 insect cells (which lack NF1-like proteins) trans-activation of CAT activity was observed.", "output": {"entities": {"gene": [{"text": "alpha1-globin", "start": 40, "end": 53}, {"text": "CAT", "start": 63, "end": 66}, {"text": "CCAAT transcription factor 1", "start": 100, "end": 128}, {"text": "CTF1", "start": 130, "end": 134}, {"text": "NF1", "start": 136, "end": 139}, {"text": "NF1-like proteins", "start": 195, "end": 212}, {"text": "CAT", "start": 234, "end": 237}]}}, "schema": []}
{"input": "Western blot analysis showed a rapid corresponding increase in p21WAF1/CIP1 protein, whereas protein levels of another member of the cyclin-dependent kinase inhibitor family, p27kip1, were unchanged.", "output": {"entities": {"gene": [{"text": "p21WAF1", "start": 63, "end": 70}, {"text": "CIP1", "start": 71, "end": 75}, {"text": "cyclin-dependent kinase inhibitor family", "start": 133, "end": 173}, {"text": "p27kip1", "start": 175, "end": 182}]}}, "schema": []}
{"input": "Aggregation of vHnf1-deficient embryonic stem cells with wild-type tetraploid embryos, which contribute exclusively to extraembryonic tissues, rescues periimplantation lethality and allows development to progress to early organogenesis.", "output": {"entities": {"gene": [{"text": "vHnf1", "start": 15, "end": 20}]}}, "schema": []}
{"input": "nos-1 and nos-2, two genes related to Drosophila nanos, regulate primordial germ cell development and survival in Caenorhabditis elegans.", "output": {"entities": {"gene": [{"text": "nos-1", "start": 0, "end": 5}, {"text": "nos-2", "start": 10, "end": 15}, {"text": "Drosophila nanos", "start": 38, "end": 54}]}}, "schema": []}
{"input": "Although upstream regulators of Tec family kinases are relatively well characterized, little is known of the downstream effectors of these enzymes.", "output": {"entities": {"gene": [{"text": "Tec family kinases", "start": 32, "end": 50}]}}, "schema": []}
{"input": "Efficient phosphorylation of BRDG1 by Tec required the PH and SH2 domains as well as the kinase domain of the latter.", "output": {"entities": {"gene": [{"text": "BRDG1", "start": 29, "end": 34}, {"text": "Tec", "start": 38, "end": 41}, {"text": "PH", "start": 55, "end": 57}, {"text": "SH2 domains", "start": 62, "end": 73}]}}, "schema": []}
{"input": "CONCLUSION: These findings imply that eotaxin either is mechanistically involved in acute asthma or serves as a biomarker for activity of the CCR3 receptor ligand system, which is functionally linked to asthma.", "output": {"entities": {"gene": [{"text": "CCR3 receptor ligand", "start": 142, "end": 162}]}}, "schema": []}
{"input": "The expression analysis of the KlHIS4 gene under phosphate starvation or high adenine supply shows that factors, such as Bas1 or Bas2, involved in the basal control may also operate in a different way in K. lactis.", "output": {"entities": {"gene": [{"text": "KlHIS4 gene", "start": 31, "end": 42}, {"text": "Bas1", "start": 121, "end": 125}, {"text": "Bas2", "start": 129, "end": 133}]}}, "schema": []}
{"input": "These thyroid hormone changes may be mediated in part by cytokines or other inflammatory mediators, acting at the level of the hypothalamus and pituitary gland, the thyroid gland, and the hepatic deiodinase system.", "output": {"entities": {"gene": [{"text": "hepatic deiodinase", "start": 188, "end": 206}]}}, "schema": []}
{"input": "ESS type 1, with FT3 low and FT4 and TSH normal, is the most frequent form.", "output": {"entities": {"gene": [{"text": "TSH", "start": 37, "end": 40}]}}, "schema": []}
{"input": "METHODS: We studied 20 symptomatic patients with HOCM (12 men), mean age 52 +/-17 years, before and after septal reduction using echocardiography and electrocardiogram (ECG).", "output": {"entities": {}}, "schema": []}
{"input": "Paleoceanographic data from the Laurentian Fan, used as a proxy for sea surface temperature, reveal that surface slope waters north of the Gulf Stream experienced warming during the Little Ice Age of the 16th to 19th centuries and support the notion of an NAO-driven coupled system.", "output": {"entities": {}}, "schema": []}
{"input": "This effect required (i) IR activation since it was abrogated by IR mutation at tyrosines 1162 and 1163 and (ii) NF-kappaB activation since it was abolished by overexpression of dominant-negative IkappaB-alpha (A32/36) and mimicked by overexpression of the NF-kappaB c-Rel subunit.", "output": {"entities": {"gene": [{"text": "IR", "start": 25, "end": 27}, {"text": "IR", "start": 65, "end": 67}, {"text": "NF-kappaB", "start": 113, "end": 122}, {"text": "dominant-negative IkappaB-alpha (A32/36)", "start": 178, "end": 218}, {"text": "NF-kappaB c-Rel subunit", "start": 257, "end": 280}]}}, "schema": []}
{"input": "The factor designated B formed a complex centered on the sequence TGTGGT, a core motif recognized by members of the AML/CBFalpha transcription factor family.", "output": {"entities": {"gene": [{"text": "AML/CBFalpha transcription factor family", "start": 116, "end": 156}]}}, "schema": []}
{"input": "Furthermore, overexpression of AML3/CBFalpha1 could rescue the AML1-ETO repression.", "output": {"entities": {"gene": [{"text": "AML3", "start": 31, "end": 35}, {"text": "CBFalpha1", "start": 36, "end": 45}, {"text": "AML1", "start": 63, "end": 67}, {"text": "ETO", "start": 68, "end": 71}]}}, "schema": []}
{"input": "We examined Akt activation in Lyn-, Syk-and Btk-deficient DT40 cells and B cells from Lyn (-/-) mice.", "output": {"entities": {"gene": [{"text": "Akt", "start": 12, "end": 15}, {"text": "Lyn", "start": 30, "end": 33}, {"text": "Syk", "start": 36, "end": 39}, {"text": "Btk", "start": 44, "end": 47}, {"text": "Lyn (-/-)", "start": 86, "end": 95}]}}, "schema": []}
{"input": "Regulators of G protein signaling (RGS) proteins that contain DEP (disheveled, EGL-10, pleckstrin) and GGL (G protein gamma subunit-like) domains form a subfamily that includes the mammalian RGS proteins RGS6, RGS7, RGS9, and RGS11.", "output": {"entities": {"gene": [{"text": "G protein signaling (RGS) proteins", "start": 14, "end": 48}, {"text": "DEP", "start": 62, "end": 65}, {"text": "disheveled", "start": 67, "end": 77}, {"text": "EGL-10", "start": 79, "end": 85}, {"text": "pleckstrin", "start": 87, "end": 97}, {"text": "GGL", "start": 103, "end": 106}, {"text": "G protein gamma subunit-like", "start": 108, "end": 136}, {"text": "mammalian RGS proteins RGS6", "start": 181, "end": 208}, {"text": "RGS7", "start": 210, "end": 214}, {"text": "RGS9", "start": 216, "end": 220}, {"text": "RGS11", "start": 226, "end": 231}]}}, "schema": []}
{"input": "Cloning and expression of a specific human alpha 1, 2-mannosidase that trims Man9GlcNAc2 to Man8GlcNAc2 isomer B during N-glycan biosynthesis.", "output": {"entities": {"gene": [{"text": "human alpha 1, 2-mannosidase", "start": 37, "end": 65}]}}, "schema": []}
{"input": "The ORs of GC, adjusted for age and sex, varied from 17. 1, for those with baseline diagnoses of superficial intestinal metaplasia (IM), to 29. 3, for those with deep IM or mild dysplasia (DYS) or IM with glandular atrophy and neck hyperplasia, to 104. 2, for those with moderate or severe DYS, as compared with subjects with superficial gastritis (SG) or chronic atrophic gastritis (CAG) at baseline.", "output": {"entities": {}}, "schema": []}
{"input": "Here we report that Dbp5p and Rat7p interact through their Nterminal domains.", "output": {"entities": {"gene": [{"text": "Dbp5p", "start": 20, "end": 25}, {"text": "Rat7p", "start": 30, "end": 35}]}}, "schema": []}
{"input": "Thus, the nematode genes could be the homologs of Hh molecules in other phyla.", "output": {"entities": {"gene": [{"text": "homologs of Hh molecules", "start": 38, "end": 62}]}}, "schema": []}
{"input": "A subset of mutations in the Psi synthase domain impairs association of the altered Cbf5p proteins with selected box H/ACA snoRNAs, suggesting that the functional catalytic domain is essential for that interaction.", "output": {"entities": {"gene": [{"text": "Psi synthase domain", "start": 29, "end": 48}, {"text": "Cbf5p proteins", "start": 84, "end": 98}, {"text": "H/ACA snoRNAs", "start": 117, "end": 130}]}}, "schema": []}
{"input": "The transcription factor CHOP (C/EBP homologous protein 10) is a bZIP protein induced by a variety of stimuli that evoke cellular stress responses and has been shown to arrest cell growth and to promote programmed cell death.", "output": {"entities": {"gene": [{"text": "transcription factor CHOP", "start": 4, "end": 29}, {"text": "C/EBP homologous protein 10", "start": 31, "end": 58}, {"text": "bZIP protein", "start": 65, "end": 77}]}}, "schema": []}
{"input": "Thus, CHOP not only is a negative or a positive regulator of C/EBP target genes but also, when tethered to AP-1 factors, can activate AP-1 target genes.", "output": {"entities": {"gene": [{"text": "CHOP", "start": 6, "end": 10}, {"text": "C/EBP", "start": 61, "end": 66}, {"text": "AP-1 factors", "start": 107, "end": 119}, {"text": "AP-1", "start": 134, "end": 138}]}}, "schema": []}
{"input": "This motif, first described for the Drosophila homeobox activator DEAF-1, identifies an emerging group of metazoan transcriptional modulators.", "output": {"entities": {"gene": [{"text": "Drosophila homeobox activator DEAF-1", "start": 36, "end": 72}]}}, "schema": []}
{"input": "RNase MRP is a ribonucleoprotein endoribonuclease that has been shown to have roles in both mitochondrial DNA replication and nuclear 5. 8S rRNA processing.", "output": {"entities": {"gene": [{"text": "RNase MRP", "start": 0, "end": 9}, {"text": "nuclear 5. 8S rRNA", "start": 126, "end": 144}]}}, "schema": []}
{"input": "We have examined the regulation of the FGFR-1 gene (cek-1) in avian myogenic cultures by immunocytochemistry and Northern blot analysis.", "output": {"entities": {"gene": [{"text": "FGFR-1 gene", "start": 39, "end": 50}, {"text": "cek-1", "start": 52, "end": 57}]}}, "schema": []}
{"input": "Regulation of avian fibroblast growth factor receptor 1 (FGFR-1) gene expression during skeletal muscle differentiation.", "output": {"entities": {"gene": [{"text": "avian fibroblast growth factor receptor 1", "start": 14, "end": 55}, {"text": "FGFR-1", "start": 57, "end": 63}]}}, "schema": []}
{"input": "The backbone dynamics of residues located in the folded part of CRP2 (LIM2) R122A have been characterized by proton-detected (15) N NMR spectroscopy.", "output": {"entities": {"gene": [{"text": "CRP2", "start": 64, "end": 68}, {"text": "LIM2", "start": 70, "end": 74}, {"text": "R122A", "start": 76, "end": 81}]}}, "schema": []}
{"input": "Rac causes uncapping of actin filaments (F-actin) at the plus-ends, through phosphatidylinositol 4, 5 bisphosphate (PIP2), and eventually induces membrane ruffling.", "output": {"entities": {"gene": [{"text": "Rac", "start": 0, "end": 3}, {"text": "actin filaments", "start": 24, "end": 39}, {"text": "F-actin", "start": 41, "end": 48}]}}, "schema": []}
{"input": "However, a specific ICE/caspase-1 inhibitor called N1445 completely abolished the CK-induced apoptosis by reactivating PKB, but without affecting the CK-induced suppression of Ras transformation.", "output": {"entities": {"gene": [{"text": "ICE", "start": 20, "end": 23}, {"text": "caspase-1", "start": 24, "end": 33}, {"text": "CK", "start": 82, "end": 84}, {"text": "PKB", "start": 119, "end": 122}, {"text": "CK", "start": 150, "end": 152}, {"text": "Ras", "start": 176, "end": 179}]}}, "schema": []}
{"input": "OBJECTIVE: Although the preponderance of findings offer support for transient (where is it?) as opposed to sustained (what is it?) deficit, a need remains for specific depiction of the deficit.", "output": {"entities": {}}, "schema": []}
{"input": "The AL-R8 SI: the next generation staging container for plutonium pits at the USDOE Pantex Plant.", "output": {"entities": {}}, "schema": []}
{"input": "One form of the SBEI gene transcript in 12-day old kernels contained the exon I + II + III combination at the 5' end, whereas other forms differed by inclusion of intron 1 or exclusion of exon II sequences.", "output": {"entities": {"gene": [{"text": "SBEI gene transcript", "start": 16, "end": 36}]}}, "schema": []}
{"input": "In PC, rare MNGCs had intranuclear inclusions and grooves.", "output": {"entities": {}}, "schema": []}
{"input": "16 percent, P < 0. 001), and sustained normalization of serum alanine aminotransferase levels (41 percent vs.", "output": {"entities": {"gene": [{"text": "serum alanine aminotransferase", "start": 56, "end": 86}]}}, "schema": []}
{"input": "Its C-terminal catalytic domain was found to be highly conserved in the homologues p140 (ras-GRF) and Sos.", "output": {"entities": {"gene": [{"text": "p140", "start": 83, "end": 87}, {"text": "ras", "start": 89, "end": 92}, {"text": "GRF", "start": 93, "end": 96}, {"text": "Sos", "start": 102, "end": 105}]}}, "schema": []}
{"input": "356, 93-98].", "output": {"entities": {}}, "schema": []}
{"input": "In assays with purified enzymes, wild-type but not PTPS-S19A was a specific substrate for the cGMP-dependent protein kinase (cGK) type I and II.", "output": {"entities": {"gene": [{"text": "PTPS", "start": 51, "end": 55}, {"text": "S19A", "start": 56, "end": 60}, {"text": "cGMP-dependent protein kinase (cGK) type I and II", "start": 94, "end": 143}]}}, "schema": []}
{"input": "R., Fleischmann, R., Venter, J.", "output": {"entities": {}}, "schema": []}
{"input": "The N-terminal domain of approximately 70 kDa exhibits 11 imperfect amino acid repeats that show some homology to promastigote surface glycoproteins of the psa2/gp46 complex.", "output": {"entities": {"gene": [{"text": "psa2", "start": 156, "end": 160}, {"text": "gp46", "start": 161, "end": 165}]}}, "schema": []}
{"input": "In contrast to previously characterized proteophosphoglycans, the ppg1 gene product is predominantly membrane-associated and it is expressed on the promastigote cell surface.", "output": {"entities": {"gene": [{"text": "ppg1", "start": 66, "end": 70}]}}, "schema": []}
{"input": "Most important, infection of the cells with an adenoviral construct expressing this mutant inhibited the induction of VEGF mRNA under conditions that mimic hypoxia.", "output": {"entities": {"gene": [{"text": "VEGF mRNA", "start": 118, "end": 127}]}}, "schema": []}
{"input": "Neuregulin stimulates ErbB2, ErbB3, and ErbB4, members of the ErbB family of receptor tyrosine kinases.", "output": {"entities": {"gene": [{"text": "Neuregulin", "start": 0, "end": 10}, {"text": "ErbB2", "start": 22, "end": 27}, {"text": "ErbB3", "start": 29, "end": 34}, {"text": "ErbB4", "start": 40, "end": 45}, {"text": "ErbB family", "start": 62, "end": 73}, {"text": "receptor tyrosine kinases", "start": 77, "end": 102}]}}, "schema": []}
{"input": "Our results suggest that Anu2p is the yeast homologue of mammalian epsilon-COP and the abrupt accumulation of the ER membrane caused by a blockage of the early protein transport pathway leads to alteration of nuclear morphology of the budding yeast cells.", "output": {"entities": {"gene": [{"text": "Anu2p", "start": 25, "end": 30}, {"text": "yeast homologue of mammalian epsilon-COP", "start": 38, "end": 78}]}}, "schema": []}
{"input": "In PC12 cells, nerve growth factor induces neuronal differentiation and repressed expression of nrg-1.", "output": {"entities": {"gene": [{"text": "nerve growth factor", "start": 15, "end": 34}, {"text": "nrg-1", "start": 96, "end": 101}]}}, "schema": []}
{"input": "In a PC12 cell mutant that is deficient in protein kinase A activity (AB. 11), all three differentiating agents were unable to down-regulate nrg-1 mRNA.", "output": {"entities": {"gene": [{"text": "protein kinase A", "start": 43, "end": 59}, {"text": "nrg-1 mRNA", "start": 141, "end": 151}]}}, "schema": []}
{"input": "TSC1 mutations include two nonsense mutations, four insertions, and three splice mutations.", "output": {"entities": {"gene": [{"text": "TSC1 mutations", "start": 0, "end": 14}]}}, "schema": []}
{"input": "Twelve patients without abnormalities in the PTT are assumed to harbor missense mutations, probably in TSC2.", "output": {"entities": {"gene": [{"text": "TSC2", "start": 103, "end": 107}]}}, "schema": []}
{"input": "The first algorithm, FOREPROJ, is a fast-forward projection algorithm that allows calculation of the 3-D attenuation correction factors (ACF' s) directly from a two-dimensional (2-D) transmission scan, without first reconstructing the attenuation map and then performing a 3-D forward projection.", "output": {"entities": {}}, "schema": []}
{"input": "The RMR was measured twice in each phase and found to be similar (F (1, 18) = 0. 863) across the follicular (5018 kJ/24 h) and the luteal (5098 kJ/24 h) phases.", "output": {"entities": {}}, "schema": []}
{"input": "In gel mobility shift assays, we found no evidence for VDR-TR heterodimer interaction with any tested element.", "output": {"entities": {"gene": [{"text": "VDR", "start": 55, "end": 58}, {"text": "TR", "start": 59, "end": 61}]}}, "schema": []}
{"input": "The relative importance of these two mechanisms differed in a response element-specific manner.", "output": {"entities": {}}, "schema": []}
{"input": "After 14 d of overfeeding, hepatic PL profiles were identical in the two breeds and similar to that in control livers; choline-containing PL accounted for 95% of total PL.", "output": {"entities": {}}, "schema": []}
{"input": "C-SP duration was significantly reduced in ALS patients compared to controls at low stimulation intensity corresponding to an MEP threshold increased by 15%.", "output": {"entities": {}}, "schema": []}
{"input": "These data show that the spv virulence genes belong simultaneously to several regulons in the cell, raising the possibility that spv expression can be fine-tuned in response to multiple environmental inputs.", "output": {"entities": {"gene": [{"text": "spv virulence genes", "start": 25, "end": 44}, {"text": "spv", "start": 129, "end": 132}]}}, "schema": []}
{"input": "Intensive synthesis of PNA in the cells of microvascular wall evidenced of their high functional activity, and the synthesis of DNA in them showed their ability for proliferation, i. g.--for growth.", "output": {"entities": {"gene": [{"text": "PNA", "start": 23, "end": 26}]}}, "schema": []}
{"input": "Tracheal transsection combined with hilar ligation (TL & PL) effected a reduction of 19. 9% (n. s.).", "output": {"entities": {}}, "schema": []}
{"input": "Kinase-deficient erbB proteins reduced epidermal growth factor (EGF)-induced tyrosine phosphorylation of endogenous Shc proteins and also reduced immediate and sustained EGF-induced ERK MAPK activities in human glioblastoma cells, although basal ERK MAPK activities were unaffected.", "output": {"entities": {"gene": [{"text": "erbB proteins", "start": 17, "end": 30}, {"text": "epidermal growth factor", "start": 39, "end": 62}, {"text": "EGF", "start": 64, "end": 67}, {"text": "Shc proteins", "start": 116, "end": 128}, {"text": "EGF-induced ERK MAPK", "start": 170, "end": 190}, {"text": "ERK MAPK", "start": 246, "end": 254}]}}, "schema": []}
{"input": "Using immunolocalization, we observe that ACE3, a 440-bp chorion element that contains information sufficient to drive amplification, directs DmORC localization in follicle cells.", "output": {"entities": {"gene": [{"text": "ACE3", "start": 42, "end": 46}, {"text": "DmORC", "start": 142, "end": 147}]}}, "schema": []}
{"input": "Therefore, homozygous co-deletions of CDKN2A and CDKN2B rather than mutations targeting individual transcripts are frequently selected for in these tumors.", "output": {"entities": {"gene": [{"text": "CDKN2A", "start": 38, "end": 44}, {"text": "CDKN2B", "start": 49, "end": 55}]}}, "schema": []}
{"input": "Here, we show that aortic explants isolated from PPARalpha-null mice display an exacerbated response to inflammatory stimuli, such as lipopolysaccharide (LPS), as demonstrated by increased IL-6 secretion.", "output": {"entities": {"gene": [{"text": "PPARalpha", "start": 49, "end": 58}, {"text": "IL-6", "start": 189, "end": 193}]}}, "schema": []}
{"input": "Albumin expression is maintained in the liver by a combination of liver-enriched transcription factors such as CAAT enhancer-binding protein (C/EBP) alpha and C/EBPbeta.", "output": {"entities": {"gene": [{"text": "CAAT enhancer-binding protein (C/EBP) alpha", "start": 111, "end": 154}, {"text": "C/EBPbeta", "start": 159, "end": 168}]}}, "schema": []}
{"input": "The requirement for proteolytic activity of both FVIIa and FXa suggests that protease-activated receptors may be involved.", "output": {"entities": {"gene": [{"text": "FVIIa", "start": 49, "end": 54}, {"text": "FXa", "start": 59, "end": 62}]}}, "schema": []}
{"input": "Amyloid beta-protein (Abeta) is the main constituent of amyloid fibrils found in senile plaques and cerebral vessels in Alzheimer' s disease (AD) and is derived by proteolysis from the beta-amyloid precursor protein (APP).", "output": {"entities": {"gene": [{"text": "Amyloid beta-protein", "start": 0, "end": 20}, {"text": "Abeta", "start": 22, "end": 27}, {"text": "beta-amyloid precursor protein", "start": 185, "end": 215}, {"text": "APP", "start": 217, "end": 220}]}}, "schema": []}
{"input": "The importin alpha. beta heterodimer mediates nuclear import of proteins containing classical nuclear localization signals.", "output": {"entities": {"gene": [{"text": "importin alpha. beta heterodimer", "start": 4, "end": 36}]}}, "schema": []}
{"input": "The expressed G1-G2 bound to both hyaluronan and link protein indicating that the immunoglobulin-fold motif and proteoglycan tandem repeat loops of the G1 domain were correctly folded.", "output": {"entities": {"gene": [{"text": "G1", "start": 14, "end": 16}, {"text": "G2", "start": 17, "end": 19}, {"text": "link protein", "start": 49, "end": 61}, {"text": "immunoglobulin-fold motif", "start": 82, "end": 107}, {"text": "G1 domain", "start": 152, "end": 161}]}}, "schema": []}
{"input": "The results suggest that the presence or absence per se of keratan sulfate on native G1-G2 does not affect the activity of atrolysin C toward the two sites.", "output": {"entities": {}}, "schema": []}
{"input": "Despite i. v. steroid therapy, [NOexh] remained elevated throughout recovery (37. 9 +/-4. 8 ppb, p < 0. 001) until discharge (40. 9 +/-4. 3 ppb, p < 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "It contains binding sites for several transcription factors, for example: (i) a well-characterized binding site for rel/NF-kappaB transcription factors in its 3'-end (the H2TF1 or kappaB1 element), (ii) a second kappaB site (the kappaB2 element), which is located immediately adjacent 5' to the H2TF1 element and which is recognized by p65/relA in the human HLA system, and (iii) an AP-1/ATF recognition sequence in the 5' end (EnA-TRE).", "output": {"entities": {"gene": [{"text": "rel", "start": 116, "end": 119}, {"text": "NF-kappaB", "start": 120, "end": 129}, {"text": "H2TF1", "start": 171, "end": 176}, {"text": "kappaB1 element", "start": 180, "end": 195}, {"text": "kappaB site", "start": 212, "end": 223}, {"text": "kappaB2 element", "start": 229, "end": 244}, {"text": "H2TF1 element", "start": 295, "end": 308}, {"text": "p65", "start": 336, "end": 339}, {"text": "relA", "start": 340, "end": 344}, {"text": "human HLA", "start": 352, "end": 361}, {"text": "AP-1", "start": 383, "end": 387}, {"text": "ATF", "start": 388, "end": 391}, {"text": "EnA-TRE", "start": 428, "end": 435}]}}, "schema": []}
{"input": "The tumorigenic E1A + cHa-ras cells are characterized by high and constitutive DNA binding activities of AP-1, in contrast to nontransformed cells and the E1A cells.", "output": {"entities": {"gene": [{"text": "E1A", "start": 16, "end": 19}, {"text": "cHa-ras", "start": 22, "end": 29}, {"text": "AP-1", "start": 105, "end": 109}, {"text": "E1A", "start": 155, "end": 158}]}}, "schema": []}
{"input": "The yeast C-type cyclin Ume3p/Srb11p and its cyclin-dependent kinase (Cdk) Ume5p are required for the full repression of genes involved in the stress response or meiosis.", "output": {"entities": {"gene": [{"text": "C-type cyclin Ume3p", "start": 10, "end": 29}, {"text": "Srb11p", "start": 30, "end": 36}, {"text": "cyclin-dependent kinase", "start": 45, "end": 68}, {"text": "Cdk", "start": 70, "end": 73}, {"text": "Ume5p", "start": 75, "end": 80}]}}, "schema": []}
{"input": "In particular, the S1' specificity site is a deep and highly hydrophobic cavity.", "output": {"entities": {"gene": [{"text": "S1' specificity site", "start": 19, "end": 39}]}}, "schema": []}
{"input": "FZD4 is homologous to FZD9 and FZD10, and overall amino acid identity is as follows: FZD4 vs FZD9, 51. 6%; FZD4 vs FZD10, 51. 2%; FZD9 vs FZD10, 65. 7%.", "output": {"entities": {"gene": [{"text": "FZD4", "start": 0, "end": 4}, {"text": "FZD9", "start": 22, "end": 26}, {"text": "FZD10", "start": 31, "end": 36}, {"text": "FZD4", "start": 85, "end": 89}, {"text": "FZD9", "start": 93, "end": 97}, {"text": "FZD4", "start": 107, "end": 111}, {"text": "FZD10", "start": 115, "end": 120}, {"text": "FZD9", "start": 130, "end": 134}, {"text": "FZD10", "start": 138, "end": 143}]}}, "schema": []}
{"input": "The NF-kappaB responsive reporter construct, (PRDII) (4)-CAT, was used to explore transcription resulting from NF-kappaB activated by Tat.", "output": {"entities": {"gene": [{"text": "NF-kappaB", "start": 4, "end": 13}, {"text": "(PRDII) (4)", "start": 45, "end": 56}, {"text": "CAT", "start": 57, "end": 60}, {"text": "NF-kappaB", "start": 111, "end": 120}, {"text": "Tat", "start": 134, "end": 137}]}}, "schema": []}
{"input": "The RNA transcripts structurally equivalent to I (2) sgRNAs of TMV U1 and crTMV, but containing a hairpin structure (H) immediately upstream of IRES (MP, 75) (HIRES (MP), (75) (CR)-MP-CP-3' UTR; HIRES (MP, 75) (U1)-MP-CP-3' UTR), were able to express the MP gene in vitro.", "output": {"entities": {"gene": [{"text": "I (2) sgRNAs", "start": 47, "end": 59}, {"text": "TMV U1", "start": 63, "end": 69}, {"text": "IRES (MP, 75) (HIRES (MP), (75) (CR)-MP-CP-3' UTR", "start": 144, "end": 193}, {"text": "HIRES (MP, 75) (U1)-MP-CP-3' UTR", "start": 195, "end": 227}, {"text": "MP gene", "start": 255, "end": 262}]}}, "schema": []}
{"input": "EIAV LTR sequence variability is confined mostly to a small portion of the enhancer within the U3 segment of the LTR.", "output": {"entities": {"gene": [{"text": "EIAV LTR sequence", "start": 0, "end": 17}]}}, "schema": []}
{"input": "The core of this enhancer contains two evolutionarily conserved binding sites for the homeodomain protein Tinman (Tin), expressed in developing cardiac, somatic, and visceral muscle lineages.", "output": {"entities": {"gene": [{"text": "homeodomain protein Tinman", "start": 86, "end": 112}, {"text": "Tin", "start": 114, "end": 117}]}}, "schema": []}
{"input": "Furthermore, the striking ability of polyoma middle T antigens to promote retinoic acid-induced differentiation appears to utilize ERK, but not JNK/SPK or p38 signaling.", "output": {"entities": {"gene": [{"text": "polyoma middle T antigens", "start": 37, "end": 62}, {"text": "ERK", "start": 131, "end": 134}, {"text": "JNK", "start": 144, "end": 147}, {"text": "SPK", "start": 148, "end": 151}, {"text": "p38", "start": 155, "end": 158}]}}, "schema": []}
{"input": "All loci have a similar organization, except for H1. 8 that harbors two TcP2beta genes arranged in tandem and separated by a short repetitive sequence, named SIRE (short interspersed repetitive element), which is also found upstream of the first gene of the tandem and downstream of the second.", "output": {"entities": {"gene": [{"text": "H1. 8", "start": 49, "end": 54}, {"text": "TcP2beta genes", "start": 72, "end": 86}]}}, "schema": []}
{"input": "A proportion of APC wild-type colon carcinomas and melanomas also contains constitutive nuclear Tcf-4/beta-catenin complexes as a result of dominant mutations in the N terminus of beta-catenin that render it insensitive to downregulation by APC, GSK3 beta, and Axin/Conductin.", "output": {"entities": {"gene": [{"text": "APC", "start": 16, "end": 19}, {"text": "Tcf-4", "start": 96, "end": 101}, {"text": "beta-catenin", "start": 102, "end": 114}, {"text": "beta-catenin", "start": 180, "end": 192}, {"text": "APC", "start": 241, "end": 244}, {"text": "GSK3 beta", "start": 246, "end": 255}, {"text": "Axin", "start": 261, "end": 265}, {"text": "Conductin", "start": 266, "end": 275}]}}, "schema": []}
{"input": "Similar mechanisms leading to deregulation of Tcf target gene activity are likely to be involved in melanoma and other forms of cancer.", "output": {"entities": {"gene": [{"text": "Tcf target gene", "start": 46, "end": 61}]}}, "schema": []}
{"input": "PATIENTS AND METHODS: Immediately before radical prostatectomy, bone marrow aspirates from both sides of the iliac crest were taken from 287 patients.", "output": {"entities": {}}, "schema": []}
{"input": "With regard to nonhematologic toxicities, diarrhea, infection and elevated serum alkaline phosphatase of grade 3 or over were observed in 2% of cycles, but were tolerable and reversible.", "output": {"entities": {"gene": [{"text": "serum alkaline phosphatase", "start": 75, "end": 101}]}}, "schema": []}
{"input": "LHbeta is expressed in pituitary gonadotrope cells and CGbeta is expressed in placental trophoblast cells.", "output": {"entities": {"gene": [{"text": "LHbeta", "start": 0, "end": 6}, {"text": "CGbeta", "start": 55, "end": 61}]}}, "schema": []}
{"input": "Regulation of HIV-1 transcription.", "output": {"entities": {}}, "schema": []}
{"input": "Human LTBP-1 is known to exist in different forms.", "output": {"entities": {"gene": [{"text": "Human LTBP-1", "start": 0, "end": 12}]}}, "schema": []}
{"input": "In an earlier study (Kimura, Y., Kurzydlowski, K., Tada, M., and MacLennan, D.", "output": {"entities": {}}, "schema": []}
{"input": "It consists of 2185 amino acid residues encoded by a 9-kilobase pair mRNA; several splice variants have been detected in human and rat cDNA libraries.", "output": {"entities": {}}, "schema": []}
{"input": "Cyclic AMP-dependent protein kinase binding to A-kinase anchoring proteins in living cells by fluorescence resonance energy transfer of green fluorescent protein fusion proteins.", "output": {"entities": {"gene": [{"text": "Cyclic AMP-dependent protein kinase", "start": 0, "end": 35}, {"text": "A-kinase", "start": 47, "end": 55}, {"text": "green fluorescent protein", "start": 136, "end": 161}]}}, "schema": []}
{"input": "Factor XI deficiency is a rare hereditary bleeding disorder affecting the intrinsic pathway.", "output": {"entities": {"gene": [{"text": "Factor XI", "start": 0, "end": 9}]}}, "schema": []}
{"input": "The Ishasha samples show a range encompassing three trophic levels.", "output": {"entities": {}}, "schema": []}
{"input": "The more traditional SERMS, clomiphene citrate and tamoxifen, will be reviewed along with such modern drugs as raloxifene and faslodex, with emphasis upon their actions on breast, uterus, bone and lipids.", "output": {"entities": {}}, "schema": []}
{"input": "Ti exhibited a feather-like morphology.", "output": {"entities": {}}, "schema": []}
{"input": "This organization suggests that duplication events that have generated the primate FUT3-FUT5-FUT6 cluster might have occurred through a long-interspersed-nuclear-element-based mechanism of unequal crossing over, as described for the globin cluster.", "output": {"entities": {"gene": [{"text": "FUT3", "start": 83, "end": 87}, {"text": "FUT5", "start": 88, "end": 92}, {"text": "FUT6", "start": 93, "end": 97}, {"text": "globin cluster", "start": 233, "end": 247}]}}, "schema": []}
{"input": "S., Kim, S.", "output": {"entities": {}}, "schema": []}
{"input": "The cop region also harbors a region of plasmid incompatibility, inc, encompassing a stem-loop structure, the repA promoter, Prep, as well as two distinct RepA binding sites, BD-1 and BD-2.", "output": {"entities": {"gene": [{"text": "cop region", "start": 4, "end": 14}, {"text": "incompatibility", "start": 48, "end": 63}, {"text": "repA promoter", "start": 110, "end": 123}, {"text": "Prep", "start": 125, "end": 129}, {"text": "RepA binding sites", "start": 155, "end": 173}]}}, "schema": []}
{"input": "WA constructs afforded relaxed and positive topoisomers, and cyclization kinetics indicated slow interconversion of precursors to the two topoisomers.", "output": {"entities": {}}, "schema": []}
{"input": "The RFX protein family includes members from yeast to humans, which function in various biological systems, and share a DNA-binding domain and a conserved C-terminal region.", "output": {"entities": {"gene": [{"text": "RFX protein family", "start": 4, "end": 22}]}}, "schema": []}
{"input": "Binding to sulphatides and the alpha-dystroglycan receptor was much stronger and required at least two LG modules.", "output": {"entities": {"gene": [{"text": "alpha-dystroglycan receptor", "start": 31, "end": 58}, {"text": "LG modules", "start": 103, "end": 113}]}}, "schema": []}
{"input": "Here, we propose that an antagonistic, BMP/ALK2/Smad-mediated signaling pathway is active on the right side of the Xenopus embryo.", "output": {"entities": {"gene": [{"text": "BMP", "start": 39, "end": 42}, {"text": "ALK2", "start": 43, "end": 47}, {"text": "Smad", "start": 48, "end": 52}]}}, "schema": []}
{"input": "Gentamicin given by DPI and SVN significantly decreased the sputum Psa density (p < 0. 05), by almost one order of magnitude.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS: The largest value of the joint space may be used when evaluating rheumatoid AC joint space.", "output": {"entities": {}}, "schema": []}
{"input": "An analysis of sequence of the mutant recN gene revealed a G: C to T: A transversion near the 3' end of the coding region.", "output": {"entities": {"gene": [{"text": "mutant recN gene", "start": 31, "end": 47}]}}, "schema": []}
{"input": "Nevertheless, in view of the potential transmission rates of HGV and the lack of effective immunization, HGV should be regarded as a potential occupational hazard for medical and dental staff.", "output": {"entities": {}}, "schema": []}
{"input": "We have previously identified mouse and human cDNAs encoding UNC-51-like kinase (ULK1).", "output": {"entities": {"gene": [{"text": "mouse and human cDNAs encoding UNC-51-like kinase", "start": 30, "end": 79}, {"text": "ULK1", "start": 81, "end": 85}]}}, "schema": []}
{"input": "ULKs and UNC-51 share a typical domain structure of an amino-terminal kinase domain, a central proline/serine rich (PS) domain, and a carboxy-terminal (C) domain.", "output": {"entities": {"gene": [{"text": "ULKs", "start": 0, "end": 4}, {"text": "UNC-51", "start": 9, "end": 15}]}}, "schema": []}
{"input": "These results suggest that ULK2 is involved in a previously uncharacterized signaling pathway in mammalian cells.", "output": {"entities": {"gene": [{"text": "ULK2", "start": 27, "end": 31}]}}, "schema": []}
{"input": "Connector enhancer of KSR (CNK) is a multidomain protein required for RAS signaling.", "output": {"entities": {"gene": [{"text": "Connector enhancer of KSR", "start": 0, "end": 25}, {"text": "CNK", "start": 27, "end": 30}, {"text": "RAS", "start": 70, "end": 73}]}}, "schema": []}
{"input": "In simpler organisms, the ATP sulfurylase and APS kinase reactions are catalyzed by separate enzymes encoded by two or three genes, suggesting that a fusion of separate genes during the course of evolution generated the bifunctional enzyme.", "output": {"entities": {"gene": [{"text": "ATP sulfurylase", "start": 26, "end": 41}, {"text": "APS kinase", "start": 46, "end": 56}]}}, "schema": []}
{"input": "Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) is essential for EBV-mediated transformation of primary B lymphocytes.", "output": {"entities": {"gene": [{"text": "Epstein-Barr virus (EBV) latent membrane protein 1", "start": 0, "end": 50}, {"text": "LMP1", "start": 52, "end": 56}]}}, "schema": []}
{"input": "The amino-terminal half of 1a is a distant homolog of alphavirus nonstructural protein nsP1, which has been implicated in capping viral RNAs.", "output": {"entities": {"gene": [{"text": "1a", "start": 27, "end": 29}, {"text": "homolog of alphavirus nonstructural protein nsP1", "start": 43, "end": 91}]}}, "schema": []}
{"input": "Moreover, a recombinant Ad expressing Ad5 E4orf6/7 induced apoptosis in rat cells when coinfected with wild-type p53-expressing Ad.", "output": {"entities": {"gene": [{"text": "Ad5 E4orf6/7", "start": 38, "end": 50}, {"text": "p53", "start": 113, "end": 116}]}}, "schema": []}
{"input": "CONCLUSION (S): Measuring urinary LH levels is an excellent method for determining ovulation.", "output": {"entities": {"gene": [{"text": "LH", "start": 34, "end": 36}]}}, "schema": []}
{"input": "PURPOSE: To evaluate the disease-free survival (DFS) and overall survival (OS), prognostic factors, and treatment-related mortality of women with stage IIIB inflammatory breast cancer (IBC) treated with combined modality therapy (CMT) and high-dose chemotherapy (HDCT) with autologous stem-cell transplantation.", "output": {"entities": {}}, "schema": []}
{"input": "We have cloned a novel 100-kDa mammalian protein, which was recognized by an anti-peptide antibody against an epitope-containing nuclear localization signal of NF-kappaB p65 subunit.", "output": {"entities": {"gene": [{"text": "NF-kappaB p65 subunit", "start": 160, "end": 181}]}}, "schema": []}
{"input": "Insulin-regulated events, however, occur in all cells.", "output": {"entities": {"gene": [{"text": "Insulin", "start": 0, "end": 7}]}}, "schema": []}
{"input": "Regulatory regions in the promoter and third intron of the growth hormone gene in rainbow trout, Oncorhynchus mykiss walbaum.", "output": {"entities": {"gene": [{"text": "growth hormone gene in rainbow trout", "start": 59, "end": 95}]}}, "schema": []}
{"input": "Although most SFV genes have homologs encoded by other Chordopoxvirinae, the SFV genome lacks a key gene required for the production of extracellular enveloped virus.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, media containing F beta alpha/CG beta displayed high-affinity binding to both CG and FSH receptors.", "output": {"entities": {"gene": [{"text": "F beta alpha", "start": 30, "end": 42}, {"text": "CG beta", "start": 43, "end": 50}, {"text": "CG and FSH receptors", "start": 91, "end": 111}]}}, "schema": []}
{"input": "In contrast, AP-2 binding activity was significantly greater in T47D cells, and Western blots confirmed increased AP-2 protein levels in these cells.", "output": {"entities": {"gene": [{"text": "AP-2", "start": 13, "end": 17}, {"text": "AP-2 protein", "start": 114, "end": 126}]}}, "schema": []}
{"input": "N. van Hoek, and M.", "output": {"entities": {}}, "schema": []}
{"input": "Here, we describe a tyrosine-phosphorylated nuclear protein, YT521-B, and show that it interacts with the nuclear transcriptosomal component scaffold attachment factor B, and the 68-kDa Src substrate associated during mitosis, Sam68.", "output": {"entities": {"gene": [{"text": "YT521-B", "start": 61, "end": 68}, {"text": "nuclear transcriptosomal component scaffold attachment factor B", "start": 106, "end": 169}, {"text": "68-kDa Src", "start": 179, "end": 189}, {"text": "Sam68", "start": 227, "end": 232}]}}, "schema": []}
{"input": "These mutants all failed to interact with the TraR fusion in the two-hybrid system.", "output": {"entities": {"gene": [{"text": "TraR fusion", "start": 46, "end": 57}]}}, "schema": []}
{"input": "PhoP-PhoQ homologues in Pseudomonas aeruginosa regulate expression of the outer-membrane protein OprH and polymyxin B resistance.", "output": {"entities": {"gene": [{"text": "PhoP", "start": 0, "end": 4}, {"text": "PhoQ", "start": 5, "end": 9}, {"text": "outer-membrane protein OprH", "start": 74, "end": 101}]}}, "schema": []}
{"input": "Deletion of fdsR revealed a dual regulatory effect of FdsR on the fds operon by acting as transcriptional activator in the presence of formate or as repressor in the absence of formate.", "output": {"entities": {"gene": [{"text": "fdsR", "start": 12, "end": 16}, {"text": "FdsR", "start": 54, "end": 58}, {"text": "fds operon", "start": 66, "end": 76}]}}, "schema": []}
{"input": "With constructs containing the binding site of one gene fused to the promoter of the other, we demonstrated that the positional requirements are a function of the specific binding site, not the promoter.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, all three Opa proteins of C751 bind equally well to HeLa cells transfected with cDNA encoding the carcinoembryonic antigen [CEA (CD66e)] subgroup of the CD66 family, but show distinct tropism for CGM1-(CD66d) and NCA (CD66c)-expressing cells.", "output": {"entities": {"gene": [{"text": "Opa proteins", "start": 23, "end": 35}, {"text": "carcinoembryonic antigen", "start": 111, "end": 135}, {"text": "CEA", "start": 137, "end": 140}, {"text": "CD66e", "start": 142, "end": 147}, {"text": "CD66 family", "start": 166, "end": 177}, {"text": "CGM1", "start": 209, "end": 213}, {"text": "CD66d", "start": 215, "end": 220}, {"text": "NCA", "start": 226, "end": 229}, {"text": "CD66c", "start": 231, "end": 236}]}}, "schema": []}
{"input": "The effect of smoking was not examined in this study, as such data were not available.", "output": {"entities": {}}, "schema": []}
{"input": "BACKGROUND: Measurement of stereoacuity at varying distances, by real or simulated depth stereoacuity tests, is helpful in the evaluation of patients with binocular imbalance or strabismus.", "output": {"entities": {}}, "schema": []}
{"input": "Additional studies revealed that bovine brain Galpha (q/11) could also bind to an N-terminal construct of GRK2, while no binding of Galpha (q/11), Galpha (s), Galpha (i), or Galpha (12/13) to comparable constructs of GRK5 or GRK6 was observed.", "output": {"entities": {"gene": [{"text": "bovine brain Galpha (q/11)", "start": 33, "end": 59}, {"text": "GRK2", "start": 106, "end": 110}, {"text": "Galpha (q/11)", "start": 132, "end": 145}, {"text": "Galpha (s)", "start": 147, "end": 157}, {"text": "Galpha (i)", "start": 159, "end": 169}, {"text": "Galpha (12/13)", "start": 174, "end": 188}, {"text": "GRK5", "start": 217, "end": 221}, {"text": "GRK6", "start": 225, "end": 229}]}}, "schema": []}
{"input": "The elm1 kinase functions in a mitotic signaling network in budding yeast.", "output": {"entities": {"gene": [{"text": "elm1 kinase", "start": 4, "end": 15}]}}, "schema": []}
{"input": "Reverse transcription (RT)-PCR products were synthesized with two degenerate primers derived from the conserved motifs of various tyrosine kinases.", "output": {"entities": {"gene": [{"text": "tyrosine kinases", "start": 130, "end": 146}]}}, "schema": []}
{"input": "In addition, the acetyltransferase activity of p300 was observed to be distinct from the broadly essential activation function of the CH3 domain/E1A-binding region.", "output": {"entities": {"gene": [{"text": "p300", "start": 47, "end": 51}, {"text": "CH3 domain", "start": 134, "end": 144}, {"text": "E1A", "start": 145, "end": 148}]}}, "schema": []}
{"input": "The proliferation-specific HNF-3/fork head homolog-11B protein (HFH-11B; also known as Trident and Win) is a family member of the winged helix/fork head transcription factors and in regenerating liver its expression is reactivated prior to hepatocyte entry into DNA replication (S phase).", "output": {"entities": {"gene": [{"text": "HNF-3", "start": 27, "end": 32}, {"text": "fork head homolog-11B", "start": 33, "end": 54}, {"text": "HFH-11B", "start": 64, "end": 71}, {"text": "Trident", "start": 87, "end": 94}, {"text": "Win", "start": 99, "end": 102}, {"text": "winged helix", "start": 130, "end": 142}, {"text": "fork head", "start": 143, "end": 152}]}}, "schema": []}
{"input": "In the mouse, CtBP1 is expressed from embryo to adult, but CtBP2 is mainly expressed during embryogenesis.", "output": {"entities": {"gene": [{"text": "CtBP1", "start": 14, "end": 19}, {"text": "CtBP2", "start": 59, "end": 64}]}}, "schema": []}
{"input": "The multiple functions of Pmt3p described here suggest that several nuclear proteins are regulated by Pmt3p conjugation.", "output": {"entities": {"gene": [{"text": "Pmt3p", "start": 26, "end": 31}, {"text": "Pmt3p", "start": 102, "end": 107}]}}, "schema": []}
{"input": "The role of transport by sea ice from the Kara Sea into the Arctic Ocean was assessed by a small subgroup at GEOMAR.", "output": {"entities": {}}, "schema": []}
{"input": "We determined whether a single injection of slow-release estradiol-17beta (SRE2) would induce pseudopregnancy in gilts and whether PGF2alpha would regress the corpora lutea (CL) of pseudopregnancy.", "output": {"entities": {}}, "schema": []}
{"input": "Among the remaining 22 sites, six are in the promoters of known alpha-specific genes and two other sites have an alpha2-Mcm1-dependent role in determining the direction of mating type switching.", "output": {"entities": {"gene": [{"text": "alpha2", "start": 113, "end": 119}, {"text": "Mcm1", "start": 120, "end": 124}]}}, "schema": []}
{"input": "Activation of T cells via the TCR and other costimulatory receptors triggers a number of signaling cascades.", "output": {"entities": {"gene": [{"text": "TCR", "start": 30, "end": 33}]}}, "schema": []}
{"input": "A phylogenetic analysis with the TK domains from these sequences and a fourth, from a novel scavenger RTK (all domains comprise the signature for the TK class II receptors), showed that they are distantly related to the insulin and insulin-like receptors.", "output": {"entities": {"gene": [{"text": "TK domains", "start": 33, "end": 43}, {"text": "scavenger RTK", "start": 92, "end": 105}, {"text": "TK class II receptors", "start": 150, "end": 171}, {"text": "insulin", "start": 220, "end": 227}, {"text": "insulin-like receptors", "start": 232, "end": 254}]}}, "schema": []}
{"input": "Results confirmed that stress produced CA3 dendritic atrophy and tianeptine prevented it.", "output": {"entities": {}}, "schema": []}
{"input": "We have isolated a binding partner for the Fanconi anemia group C protein (FANCC) by yeast two-hybrid screening.", "output": {"entities": {"gene": [{"text": "Fanconi anemia group C protein", "start": 43, "end": 73}, {"text": "FANCC", "start": 75, "end": 80}]}}, "schema": []}
{"input": "These results suggest that both transcription activators depend on or interact with different subunits of RNA polymerase, although their role in formation of proper DNA geometry may also be crucial.", "output": {"entities": {"gene": [{"text": "RNA polymerase", "start": 106, "end": 120}]}}, "schema": []}
{"input": "Klebsiella oxytoca can assimilate nitrate and nitrite by using enzymes encoded by the nasFEDCBA operon.", "output": {"entities": {"gene": [{"text": "nasFEDCBA operon", "start": 86, "end": 102}]}}, "schema": []}
{"input": "Marked hemolysis significantly increased plasma values of potassium, phosphorus, total protein, and aspartate aminotransferase.", "output": {"entities": {"gene": [{"text": "aspartate aminotransferase", "start": 100, "end": 126}]}}, "schema": []}
{"input": "Studies have substantiated the involvement of numerous loci on certain chromosomes; in excess of 10 chromosomes are thought to be involved.", "output": {"entities": {}}, "schema": []}
{"input": "By negatively regulating GRK-mediated receptor phosphorylation, beta-arrestin-mediated processes such as Src recruitment and clathrin-mediated internalization, which are required for GPCR-mediated ERK activation, are inhibited, thus dampening further ERK activation.", "output": {"entities": {"gene": [{"text": "GRK", "start": 25, "end": 28}, {"text": "beta-arrestin", "start": 64, "end": 77}, {"text": "Src", "start": 105, "end": 108}, {"text": "clathrin", "start": 125, "end": 133}, {"text": "GPCR", "start": 183, "end": 187}, {"text": "ERK", "start": 197, "end": 200}, {"text": "ERK", "start": 251, "end": 254}]}}, "schema": []}
{"input": "Based on subcellular fractionation, the 47-kDa P-CIP2 protein is mostly cytosolic.", "output": {"entities": {"gene": [{"text": "47-kDa P-CIP2 protein", "start": 40, "end": 61}]}}, "schema": []}
{"input": "Supershift EMSAs identified that upstream stimulatory factor-1 and-2 (USF-1 and-2) were part of these complexes.", "output": {"entities": {"gene": [{"text": "upstream stimulatory factor-1 and-2", "start": 33, "end": 68}, {"text": "USF-1 and-2", "start": 70, "end": 81}]}}, "schema": []}
{"input": "Conversely, E1A binding to only p300/CBP results in an increase in PARP enzyme activity and consequently in cell death susceptibility to irradiation, which is effectively counteracted by the PARP chemical inhibitor 3-aminobenzamide.", "output": {"entities": {"gene": [{"text": "E1A", "start": 12, "end": 15}, {"text": "p300", "start": 32, "end": 36}, {"text": "CBP", "start": 37, "end": 40}, {"text": "PARP enzyme", "start": 67, "end": 78}, {"text": "PARP", "start": 191, "end": 195}]}}, "schema": []}
{"input": "These include the CACCC and CAAT motifs.", "output": {"entities": {}}, "schema": []}
{"input": "Skin pH changes associated with iontophoresis.", "output": {"entities": {}}, "schema": []}
{"input": "This distinction was based upon whether the diagnosis provided a straightforward range of prognoses or an ambiguous clinical implication.", "output": {"entities": {}}, "schema": []}
{"input": "The availability of potent regulatory DNA cassettes harboring the murine D1A gene promoter could aid testing the neuronal-specific expression of transgenes in vivo.", "output": {"entities": {"gene": [{"text": "murine D1A gene promoter", "start": 66, "end": 90}]}}, "schema": []}
{"input": "It may be dependent on location of a focus (according to EEG) as well as on the character and manifestation of the accompanying neuropsychologic symptomatology.", "output": {"entities": {}}, "schema": []}
{"input": "The results of these studies demonstrate that the rat HDL receptor SR-BI promoter contains two sterol response elements (pSRE and dSRE) through which SREBP-1a can bind and activate transcription of this gene.", "output": {"entities": {"gene": [{"text": "SR-BI", "start": 67, "end": 72}, {"text": "SREBP-1a", "start": 150, "end": 158}]}}, "schema": []}
{"input": "Of these patients, 46, 164 were placed on a waiting list for transplantation, 23, 275 of whom received a first cadaveric transplant between 1991 and 1997.", "output": {"entities": {}}, "schema": []}
{"input": "In electrophoretic mobility shift assay (EMSA), this GLUT4 repressor element (G4RE) generated specific bands with nuclear extracts from preadipocytes, but not from adipocytes.", "output": {"entities": {"gene": [{"text": "GLUT4 repressor element", "start": 53, "end": 76}, {"text": "G4RE", "start": 78, "end": 82}]}}, "schema": []}
{"input": "Syndromes of abnormal fat redistribution and metabolic complications in HIV-infected patients.", "output": {"entities": {}}, "schema": []}
{"input": "Cytoprotection with amifostine in radiotherapy or radio-chemotherapy of head and neck tumors", "output": {"entities": {}}, "schema": []}
{"input": "Immunohistochemical staining was positive for S-100 in all 9 cases stained, positive for HMB-45 in 9 (90%) of 10, and negative for cytokeratin in all 9 cases in which myxoid melanoma remained in the block after previous sections.", "output": {"entities": {"gene": [{"text": "S-100", "start": 46, "end": 51}, {"text": "HMB-45", "start": 89, "end": 95}, {"text": "cytokeratin", "start": 131, "end": 142}]}}, "schema": []}
{"input": "Patients with types I and III MPGN did not differ in age at apparent onset, age at diagnosis, or interval from apparent onset of symptoms to diagnosis (biopsy).", "output": {"entities": {}}, "schema": []}
{"input": "Residual urinary abnormalities were significantly more frequent in patients with type III than type I MPGN.", "output": {"entities": {}}, "schema": []}
{"input": "Taken together, differences in signaling and tissue expression suggest that the human intermediate PRLr differs from the long PRLr in physiological function.", "output": {"entities": {"gene": [{"text": "human intermediate PRLr", "start": 80, "end": 103}, {"text": "long PRLr", "start": 121, "end": 130}]}}, "schema": []}
{"input": "We describe here a Drosophila melanogaster FAK homologue, DFak56, which maps to band 56D on the right arm of the second chromosome.", "output": {"entities": {"gene": [{"text": "Drosophila melanogaster FAK homologue", "start": 19, "end": 56}, {"text": "DFak56", "start": 58, "end": 64}]}}, "schema": []}
{"input": "We show here that the third SH3 domain binds to Sos, a guanine nucleotide exchange factor for Ras and Rac, both in vitro and in vivo.", "output": {"entities": {"gene": [{"text": "SH3 domain", "start": 28, "end": 38}, {"text": "Sos", "start": 48, "end": 51}, {"text": "guanine nucleotide exchange factor", "start": 55, "end": 89}, {"text": "Ras", "start": 94, "end": 97}, {"text": "Rac", "start": 102, "end": 105}]}}, "schema": []}
{"input": "Point mutations in the third SH3 domain abolished the vinexin-Sos interaction.", "output": {"entities": {"gene": [{"text": "SH3 domain", "start": 29, "end": 39}, {"text": "vinexin", "start": 54, "end": 61}, {"text": "Sos", "start": 62, "end": 65}]}}, "schema": []}
{"input": "In gel mobility shift assays, low binding activity of CBF to the wild-type AtpC promoter sequence was observed with nuclear extracts from tissue with low AtpC expression levels, i. e. extracts from etiolated and photobleached seedlings, whereas high binding activity was detectable with extracts from tissues with high AtpC expression levels, i. e. extracts from light-grown seedlings and etiolated seedlings treated with cytokinin.", "output": {"entities": {"gene": [{"text": "CBF", "start": 54, "end": 57}, {"text": "wild-type AtpC promoter sequence", "start": 65, "end": 97}, {"text": "AtpC", "start": 154, "end": 158}, {"text": "AtpC", "start": 319, "end": 323}, {"text": "cytokinin", "start": 422, "end": 431}]}}, "schema": []}
{"input": "They are subdivided into two types that activate transduction pathways via different cell surface receptors.", "output": {"entities": {}}, "schema": []}
{"input": "We report here that out of the major pro-inflammatory cytokines examined, IL-1alpha, IL-1beta, TNF-alpha and IL-6, only IL-6 was generated and secreted in PKCeta-expressing cells without any additional inducer in serum-supplemented cultures (10% FCS).", "output": {"entities": {"gene": [{"text": "IL-1alpha", "start": 74, "end": 83}, {"text": "IL-1beta", "start": 85, "end": 93}, {"text": "TNF-alpha", "start": 95, "end": 104}, {"text": "IL-6", "start": 109, "end": 113}, {"text": "IL-6", "start": 120, "end": 124}, {"text": "PKCeta", "start": 155, "end": 161}]}}, "schema": []}
{"input": "Demyelinating diseases involving the grey matter were very rare, but we must consider the presence of symmetrical thalamic involvement in patients with ADEM.", "output": {"entities": {}}, "schema": []}
{"input": "To define the minimal VDRE binding domain for human VDR (hVDR), a series of C-terminally truncated hVDR mutants (Delta134, Delta113, Delta102, Delta90, Delta84, Delta80, and Delta60) was generated and expressed in bacteria.", "output": {"entities": {"gene": [{"text": "human VDR", "start": 46, "end": 55}, {"text": "hVDR", "start": 57, "end": 61}, {"text": "hVDR mutants", "start": 99, "end": 111}]}}, "schema": []}
{"input": "These REPs, or clusters of paralogous loci, are 15-100 kb and harbor at least four ESTs and an expressed SH3GL pseudogene.", "output": {"entities": {"gene": [{"text": "SH3GL pseudogene", "start": 105, "end": 121}]}}, "schema": []}
{"input": "In part as a result of its inability to sustain radiative loses, the BB resonator has extremely low RF power requirements.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, narZ expression was induced approximately 20-fold intracellularly in Madin-Darby canine kidney epithelial cells and 16-fold in intracellular salts medium, which is believed to mimic the intracellular milieu.", "output": {"entities": {"gene": [{"text": "narZ", "start": 13, "end": 17}]}}, "schema": []}
{"input": "However, mechanisms underlying HIV-1 gene expression in the CNS are poorly understood.", "output": {"entities": {}}, "schema": []}
{"input": "Is radical trachelectomy a safe alternative to radical hysterectomy for patients with stage IA-B carcinoma of the cervix? BACKGROUND: The prognosis associated with lymph node negative, early stage carcinoma of the cervix is excellent, with 5-year survival rates greater than 90%.", "output": {"entities": {}}, "schema": []}
{"input": "A key event in this process is the selective recognition of the target membrane by the vesicle and the current view is that SNARE protein interactions likely play a central role in vesicle-target recognition and or membrane fusion.", "output": {"entities": {"gene": [{"text": "SNARE protein", "start": 124, "end": 137}]}}, "schema": []}
{"input": "Scapulae with a Type I configuration were found to have low values for the coraco-glenoid angle and coracoid overlap, which are known to be associated with a short coraco-humeral distance.", "output": {"entities": {}}, "schema": []}
{"input": "Measurements in the LWS p. a., LWS lat. and at Ward' s triangle were made in a total of 100 patients.", "output": {"entities": {}}, "schema": []}
{"input": "A group of 66 DSM-IV paranoid schizophrenic in-patients were assessed three times using the SAPS, SANS, BPRS and PAS.", "output": {"entities": {}}, "schema": []}
{"input": "Despite the high frequency of natural infection, the seropositive rates of JEV antibody still correlated well with the dose of vaccine received, i. e., 67% (1122/1664), 66% (65/97), 33% (4/12) and 40% (19/47) for children receiving 3, 2, 1, and 0 dose of JE vaccines, respectively (P < 0. 0001 Chi-square for trend test).", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, in vivo and in vitro protein-protein interaction experiments have shown that SR33 protein interacts with itself and with SR45 protein but not with two other members (SRZ21 and SRZ22) of the SR family that are known to interact with the Arabidopsis full-length U-70K only.", "output": {"entities": {"gene": [{"text": "SR33 protein", "start": 90, "end": 102}, {"text": "SR45 protein", "start": 134, "end": 146}, {"text": "SRZ21", "start": 179, "end": 184}, {"text": "SRZ22", "start": 189, "end": 194}, {"text": "SR family", "start": 203, "end": 212}, {"text": "U-70K", "start": 273, "end": 278}]}}, "schema": []}
{"input": "In summary, WT1 is enriched by oligo (dT) chromatography, as are U2AF65, the U5 small nuclear RNP-associated protein p116 and hnRNP A1.", "output": {"entities": {"gene": [{"text": "WT1", "start": 12, "end": 15}, {"text": "U2AF65", "start": 65, "end": 71}, {"text": "U5 small nuclear RNP-associated protein p116", "start": 77, "end": 121}, {"text": "A1", "start": 132, "end": 134}]}}, "schema": []}
{"input": "Six out of ten hearts from macerated stillborn infants showed varying degrees of positive staining.", "output": {"entities": {}}, "schema": []}
{"input": "Tih1 maps to distal mouse Chr 1 and human Chr 1q31, chromosomal regions that have not shown evidence for imprinting and, in contrast to Ipl, Tih1 is expressed equally from both parental alleles.", "output": {"entities": {"gene": [{"text": "Tih1", "start": 0, "end": 4}, {"text": "Ipl", "start": 136, "end": 139}, {"text": "Tih1", "start": 141, "end": 145}]}}, "schema": []}
{"input": "A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting.", "output": {"entities": {"gene": [{"text": "pleckstrin homology-related gene family", "start": 8, "end": 47}, {"text": "Ipl", "start": 59, "end": 62}, {"text": "Tssc3", "start": 63, "end": 68}, {"text": "TDAG51", "start": 70, "end": 76}, {"text": "Tih1", "start": 82, "end": 86}]}}, "schema": []}
{"input": "The potential for highly reactive nanoparticles (RNP) to absorb destructively, i. e. to neutralize highly toxic substances such as the warfare agents GA, GB, HD and VX, has been demonstrated in the laboratory.", "output": {"entities": {}}, "schema": []}
{"input": "There were minimal negative effects on hematological parameters, acid-base status, and blood gases.", "output": {"entities": {}}, "schema": []}
{"input": "Twelve out of 43 renal failure patients had troponin I 0. 13-0. 9 microg/l using Axsym method and 4 had levels of 0. 07-0. 13 microg/l using Immuno 1.", "output": {"entities": {"gene": [{"text": "troponin I", "start": 44, "end": 54}]}}, "schema": []}
{"input": "Therefore, we propose that p27 represents a crucial molecule in HMBA signaling that cannot be replaced by p21.", "output": {"entities": {"gene": [{"text": "p27", "start": 27, "end": 30}, {"text": "p21", "start": 106, "end": 109}]}}, "schema": []}
{"input": "Transient, high-level Ras-expression induces transcriptional activation of p21 mediated by a GC-rich region in p21 promoter-83-54 bp relative to the transcription initiation site containing binding sites for Sp1-family transcription factors.", "output": {"entities": {"gene": [{"text": "Ras", "start": 22, "end": 25}, {"text": "p21", "start": 75, "end": 78}, {"text": "p21 promoter", "start": 111, "end": 123}, {"text": "Sp1-family transcription factors", "start": 208, "end": 240}]}}, "schema": []}
{"input": "The RET/PTC3 rearrangement is formed by fusion of the ELE1 and RET genes, and is highly prevalent in radiation-induced post-Chernobyl papillary thyroid carcinomas.", "output": {"entities": {"gene": [{"text": "RET", "start": 4, "end": 7}, {"text": "PTC3", "start": 8, "end": 12}, {"text": "ELE1", "start": 54, "end": 58}, {"text": "RET genes", "start": 63, "end": 72}]}}, "schema": []}
{"input": "Apoptosis of small cells is still observed after co-transfection of JBD and LMP1 but in addition a few apoptotic HD-MyZ cells with large fused nuclear masses are identified suggesting that specific inhibition of JNK leads also to apoptosis of LMP1 induced RS cells.", "output": {"entities": {"gene": [{"text": "JBD", "start": 68, "end": 71}, {"text": "LMP1", "start": 76, "end": 80}, {"text": "JNK", "start": 212, "end": 215}, {"text": "LMP1", "start": 243, "end": 247}]}}, "schema": []}
{"input": "In addition to the bZIP protein Opaque2 (O2), there are other maize endosperm nuclear proteins that recognize the O2 box in 22 kDa zein gene promoters.", "output": {"entities": {"gene": [{"text": "bZIP protein Opaque2", "start": 19, "end": 39}, {"text": "O2", "start": 41, "end": 43}, {"text": "O2 box", "start": 114, "end": 120}, {"text": "zein", "start": 131, "end": 135}]}}, "schema": []}
{"input": "The mEmBP-1 protein can activate transcription from a truncated promoter containing a pentamer of the O2 site in yeast cells; however, it inhibited regulated transcription of a 22 kDa zein promoter in a transient expression assay using cultured maize endosperm cells.", "output": {"entities": {"gene": [{"text": "mEmBP-1 protein", "start": 4, "end": 19}, {"text": "O2 site", "start": 102, "end": 109}, {"text": "22 kDa zein promoter", "start": 177, "end": 197}]}}, "schema": []}
{"input": "GHB, 2 CB, HMB, are some of these recent substances.", "output": {"entities": {}}, "schema": []}
{"input": "There were 15 deaths, seven of which were felt to be avoidable.", "output": {"entities": {}}, "schema": []}
{"input": "With this GH and estrogen treatment regimen, most girls with TS can grow and develop much more in conformity with their healthy peers.", "output": {"entities": {"gene": [{"text": "GH", "start": 10, "end": 12}]}}, "schema": []}
{"input": "We propose that the reduced responsiveness of CYP3A2 is the result of preferential binding of COUP-TF at the CYP3A2 DexRE-1 site.", "output": {"entities": {"gene": [{"text": "CYP3A2", "start": 46, "end": 52}, {"text": "COUP-TF", "start": 94, "end": 101}, {"text": "CYP3A2 DexRE-1 site", "start": 109, "end": 128}]}}, "schema": []}
{"input": "Higher CYP3A23 basal activity appears to be due to an E-box in 3A23SiteA that interacts with USF1, a ubiquitous bHLH/leucine zipper transcription factor.", "output": {"entities": {"gene": [{"text": "CYP3A23", "start": 7, "end": 14}, {"text": "3A23SiteA", "start": 63, "end": 72}, {"text": "USF1", "start": 93, "end": 97}, {"text": "bHLH/leucine zipper transcription factor", "start": 112, "end": 152}]}}, "schema": []}
{"input": "The first one is a TPA-responsive element that controls the base-line ST3 promoter activity but is not required for its activation.", "output": {"entities": {"gene": [{"text": "ST3 promoter", "start": 70, "end": 82}]}}, "schema": []}
{"input": "To understand the basis for the increased cell surface stability compared with wild-type peptide and to understand the differences in T cell recognition between I1Y and I1F, we determined the x-ray crystal structures of the two class I MHC-peptide complexes.", "output": {"entities": {"gene": [{"text": "I1Y", "start": 161, "end": 164}, {"text": "I1F", "start": 169, "end": 172}, {"text": "class I MHC-peptide complexes", "start": 228, "end": 257}]}}, "schema": []}
{"input": "Redistribution of mannosidase I was also observed in cells incubated at 15 degrees C.", "output": {"entities": {"gene": [{"text": "mannosidase I", "start": 18, "end": 31}]}}, "schema": []}
{"input": "In addition, using biochemical activity assays for Rho-like GTPases, we show that the expression of beta1A, beta1D, or IL2R-beta1A in GE11 or GD25 cells triggers activation of both RhoA and Rac1, but not of Cdc42.", "output": {"entities": {"gene": [{"text": "Rho", "start": 51, "end": 54}, {"text": "GTPases", "start": 60, "end": 67}, {"text": "beta1A", "start": 100, "end": 106}, {"text": "beta1D", "start": 108, "end": 114}, {"text": "IL2R", "start": 119, "end": 123}, {"text": "beta1A", "start": 124, "end": 130}, {"text": "RhoA", "start": 181, "end": 185}, {"text": "Rac1", "start": 190, "end": 194}, {"text": "Cdc42", "start": 207, "end": 212}]}}, "schema": []}
{"input": "In conclusion, our data do not support a role for IVIg in the remyelination of stable multiple sclerosis lesions as measured by central conduction time.", "output": {"entities": {"gene": [{"text": "IVIg", "start": 50, "end": 54}]}}, "schema": []}
{"input": "The rhabdomyosarcoma R1H growing on the right flank of male WAG/Rij rats was clamped for 2 or 4 h at 20 degrees C or 37 degrees C.", "output": {"entities": {}}, "schema": []}
{"input": "Relative to coherent control words (e. g., quick), these discourse-dependent semantic anomalies elicited a large N400 effect that began at about 200 to 250 msec after word onset.", "output": {"entities": {}}, "schema": []}
{"input": "These synergistic effects were strongly Jem-1 dose-dependent.", "output": {"entities": {"gene": [{"text": "Jem-1", "start": 40, "end": 45}]}}, "schema": []}
{"input": "Like the Tob protein, Tob2 inhibited cell cycle progression from the G0/G1 to S phases.", "output": {"entities": {"gene": [{"text": "Tob protein", "start": 9, "end": 20}, {"text": "Tob2", "start": 22, "end": 26}]}}, "schema": []}
{"input": "The coordinate increase in cyclin D1 and p21 had the effect of decreasing the specific but not absolute activity of cyclin D1/cdk4. p53 was not involved since CSF-1 induction of p21 was unaffected by dominant-negative p53 expression.", "output": {"entities": {"gene": [{"text": "cyclin D1", "start": 27, "end": 36}, {"text": "p21", "start": 41, "end": 44}, {"text": "cyclin D1", "start": 116, "end": 125}, {"text": "cdk4", "start": 126, "end": 130}, {"text": "p53", "start": 132, "end": 135}, {"text": "CSF-1", "start": 159, "end": 164}, {"text": "p21", "start": 178, "end": 181}, {"text": "dominant-negative p53", "start": 200, "end": 221}]}}, "schema": []}
{"input": "In addition, SLK displays high homology to microtubule and nuclear associated protein (M-NAP) and AT1-46, both of unknown function.", "output": {"entities": {"gene": [{"text": "SLK", "start": 13, "end": 16}, {"text": "microtubule and nuclear associated protein", "start": 43, "end": 85}, {"text": "M-NAP", "start": 87, "end": 92}, {"text": "AT1-46", "start": 98, "end": 104}]}}, "schema": []}
{"input": "In this study 26 patients (20 females and 6 males) were evaluated.", "output": {"entities": {}}, "schema": []}
{"input": "The signalling molecules Wnt1 and Sonic hedgehog, implicated in the activation of Myf5 in myogenic progenitor cells in the somite, are also produced in the viscinity of the Myf5 expression domain in the mesencephalon.", "output": {"entities": {"gene": [{"text": "Wnt1", "start": 25, "end": 29}, {"text": "Sonic hedgehog", "start": 34, "end": 48}, {"text": "Myf5", "start": 82, "end": 86}, {"text": "Myf5 expression domain", "start": 173, "end": 195}]}}, "schema": []}
{"input": "STUDY DESIGN AND METHODS: A study was initiated to compare the collection of PBPCs with the new device, the AutoPBSC (version [V] 6. 0 with AutoPBSC tubing set), and that with the MNC (mononuclear cell) procedure (V4. 7 with white cell tubing set), for patients and healthy donors.", "output": {"entities": {}}, "schema": []}
{"input": "Albumin dialysis: effective removal of copper in a patient with fulminant Wilson disease and successful bridging to liver transplantation: a new possibility for the elimination of protein-bound toxins.", "output": {"entities": {"gene": [{"text": "Albumin", "start": 0, "end": 7}]}}, "schema": []}
{"input": "Some artificial promoter constructs containing multiple Sp1 sites were highly responsive to ethanol, but others were not, suggesting that the organization of the proximal promoter region was an additional factor that affected the ethanol response.", "output": {"entities": {"gene": [{"text": "Sp1 sites", "start": 56, "end": 65}]}}, "schema": []}
{"input": "Overexpression of CDP/cut in ROS 17/2. 8 osteosarcoma cells results in repression of OC promoter activity; this repression is abrogated by mutating OC box I.", "output": {"entities": {"gene": [{"text": "CDP", "start": 18, "end": 21}, {"text": "cut", "start": 22, "end": 25}, {"text": "OC promoter", "start": 85, "end": 96}, {"text": "OC box I", "start": 148, "end": 156}]}}, "schema": []}
{"input": "Injection of double-stranded RNA into C. elegans results in embryonic lethality; thus, the SF1 gene is essential not only in yeast but also in at least one metazoan.", "output": {"entities": {"gene": [{"text": "SF1 gene", "start": 91, "end": 99}]}}, "schema": []}
{"input": "Both domains were required for specific DNA binding to the beta-retinoic acid receptor element, producing a DNase I footprint covering predominantly one strand.", "output": {"entities": {"gene": [{"text": "beta-retinoic acid receptor element", "start": 59, "end": 94}, {"text": "DNase I", "start": 108, "end": 115}]}}, "schema": []}
{"input": "Snail family proteins are zinc finger transcriptional regulators first identified in Drosophila which play critical roles in cell fate determination.", "output": {"entities": {"gene": [{"text": "Snail family proteins", "start": 0, "end": 21}]}}, "schema": []}
{"input": "Consistent with this finding, beta-catenin interacted directly with the RA receptor (RAR) in a retinoid-dependent manner, but not with the retinoid X receptor (RXR), and RAR competed with TCF for beta-catenin binding.", "output": {"entities": {"gene": [{"text": "beta-catenin", "start": 30, "end": 42}, {"text": "RA receptor", "start": 72, "end": 83}, {"text": "RAR", "start": 85, "end": 88}, {"text": "retinoid X receptor", "start": 139, "end": 158}, {"text": "RXR", "start": 160, "end": 163}, {"text": "RAR", "start": 170, "end": 173}, {"text": "TCF", "start": 188, "end": 191}, {"text": "beta-catenin", "start": 196, "end": 208}]}}, "schema": []}
{"input": "Thrombolysis was followed by a similar increase of platelet activity with maximal values reached at the 3rd hour in both groups (196 +/-43 IU/ml in Group 1 and 192 +/-39 in Group 2: p & lt; 001versus baseline and p NS between the groups).", "output": {"entities": {}}, "schema": []}
{"input": "Similar to Hp140, isolated Hp55 binds DNA with moderate strength and was a specificity for double-stranded primer-template DNA.", "output": {"entities": {"gene": [{"text": "Hp140", "start": 11, "end": 16}, {"text": "Hp55", "start": 27, "end": 31}]}}, "schema": []}
{"input": "Finally, three new missense mutations, E138V, R254G, and P362R, were identified in the human AC gene from FD patients.", "output": {"entities": {"gene": [{"text": "human AC gene", "start": 87, "end": 100}]}}, "schema": []}
{"input": "These data indicate that the interaction of eIF4A with the middle region of eIF4GI is necessary for translation, whereas the interaction of eIF4A with the C-terminal region plays a modulatory role.", "output": {"entities": {"gene": [{"text": "eIF4A", "start": 44, "end": 49}, {"text": "eIF4GI", "start": 76, "end": 82}, {"text": "eIF4A", "start": 140, "end": 145}]}}, "schema": []}
{"input": "The DAP5/p86 apoptotic form was more potent than DAP5/p97 in these functional assays.", "output": {"entities": {"gene": [{"text": "DAP5", "start": 4, "end": 8}, {"text": "p86", "start": 9, "end": 12}, {"text": "DAP5", "start": 49, "end": 53}, {"text": "p97", "start": 54, "end": 57}]}}, "schema": []}
{"input": "12: 2684-2697, 1998): a key step of this model is the activation of the MAPK Fus3p through the G (betagamma)-dependent relocalization of the Ste5p-MAPK cascade to the plasma membrane.", "output": {"entities": {"gene": [{"text": "MAPK Fus3p", "start": 72, "end": 82}, {"text": "G (betagamma)", "start": 95, "end": 108}, {"text": "Ste5p", "start": 141, "end": 146}, {"text": "MAPK", "start": 147, "end": 151}]}}, "schema": []}
{"input": "Consistent with this finding, wild-type SAGA inhibits TBP binding to the HIS3 promoter in vitro, while SAGA lacking Spt3 or Spt8 is not inhibitory.", "output": {"entities": {"gene": [{"text": "wild-type SAGA", "start": 30, "end": 44}, {"text": "TBP", "start": 54, "end": 57}, {"text": "HIS3 promoter", "start": 73, "end": 86}, {"text": "SAGA", "start": 103, "end": 107}, {"text": "Spt3", "start": 116, "end": 120}, {"text": "Spt8", "start": 124, "end": 128}]}}, "schema": []}
{"input": "Saccharomyces cerevisiae contains a genetically and biochemically proven CAK gene, CAK1, that encodes a monomeric 44-kDa Cak1p protein unrelated to Cdk7.", "output": {"entities": {"gene": [{"text": "CAK gene", "start": 73, "end": 81}, {"text": "CAK1", "start": 83, "end": 87}, {"text": "44-kDa Cak1p protein", "start": 114, "end": 134}, {"text": "Cdk7", "start": 148, "end": 152}]}}, "schema": []}
{"input": "Northern blot and reverse transcription-PCR analyses of human mRNA samples demonstrate that RNR is expressed exclusively in the retina, with transcripts of approximately 7. 5 kb, approximately 3. 0 kb, and approximately 2. 3 kb by Northern blot analysis.", "output": {"entities": {"gene": [{"text": "RNR", "start": 92, "end": 95}]}}, "schema": []}
{"input": "Particularly striking was the conservation of an AP-4 binding site within 100 nucleotides upstream of the transcription initiation site in both Aal-rpL34 and Aal-rpL8 genes.", "output": {"entities": {"gene": [{"text": "AP-4 binding site", "start": 49, "end": 66}, {"text": "Aal", "start": 144, "end": 147}, {"text": "rpL34", "start": 148, "end": 153}, {"text": "Aal", "start": 158, "end": 161}, {"text": "rpL8", "start": 162, "end": 166}]}}, "schema": []}
{"input": "CONCLUSIONS: Serum levels of S-100beta are reliable markers for adverse neurologic outcomes after cardiac surgery.", "output": {"entities": {"gene": [{"text": "S-100beta", "start": 29, "end": 38}]}}, "schema": []}
{"input": "All problems were associated with fractured or lost screws.", "output": {"entities": {}}, "schema": []}
{"input": "The accumulated products of ancient duplication events can be readily observed among the genes encoding voltage-dependent Ca (2 +) ion channels.", "output": {"entities": {}}, "schema": []}
{"input": "The VirR response regulator from Clostridium perfringens binds independently to two imperfect direct repeats located upstream of the pfoA promoter.", "output": {"entities": {"gene": [{"text": "VirR response regulator", "start": 4, "end": 27}, {"text": "pfoA promoter", "start": 133, "end": 146}]}}, "schema": []}
{"input": "Cloning and sequencing of the upstream region of pepX revealed the presence of two ORFs of 360 and 1, 338 bp that were shown to be able to encode proteins with high homology to GlnR and GlnA proteins, respectively.", "output": {"entities": {"gene": [{"text": "pepX", "start": 49, "end": 53}, {"text": "GlnR", "start": 177, "end": 181}, {"text": "GlnA proteins", "start": 186, "end": 199}]}}, "schema": []}
{"input": "Objective: To evaluate endometrial thickness and the incidence of uterine bleeding in postmenopausal women using either tibolone 2. 5 mg or continuous combined 2 mg estradiol and 1 mg norethisterone acetate (E + NETA) daily as hormone replacement therapy.", "output": {"entities": {}}, "schema": []}
{"input": "Histological analysis showed that the neuronal loss in the DHED-treated group was notably reduced in the hippocampal area (CA1) of ischemic rats and in the dentate gyrus and hippocampal area (CA1 and CA3) of EC-lesioned rats compared with the nontreated group.", "output": {"entities": {}}, "schema": []}
{"input": "The extents of phosphorylation of Ser44 and Ser64 were 1: 1, whereas those of the four minor sites all together were < 30% of the major one.", "output": {"entities": {}}, "schema": []}
{"input": "Serum HBV-DNA, viral serology, and liver enzymes were measured sequentially; liver histology was taken before and during treatment in 12 patients.", "output": {"entities": {}}, "schema": []}
{"input": "Chem.", "output": {"entities": {}}, "schema": []}
{"input": "Maximum induction of AP-1 was reached at a concentration of 250 nmol/L of CalC.", "output": {"entities": {"gene": [{"text": "AP-1", "start": 21, "end": 25}]}}, "schema": []}
{"input": "Rams were weighed and testis size was estimated by orchimetry at each time period.", "output": {"entities": {}}, "schema": []}
{"input": "Animal studies showed that beam equalization significantly improved fluoroscopic and angiographic image quality.", "output": {"entities": {}}, "schema": []}
{"input": "Role of estrogen receptor ligand and estrogen response element sequence on interaction with chicken ovalbumin upstream promoter transcription factor (COUP-TF).", "output": {"entities": {"gene": [{"text": "estrogen receptor", "start": 8, "end": 25}, {"text": "chicken ovalbumin upstream promoter transcription factor", "start": 92, "end": 148}, {"text": "COUP-TF", "start": 150, "end": 157}]}}, "schema": []}
{"input": "CONCLUSION: In Cdks functioning throughout the cell cycle, tyrosine phosphorylation is inhibitory to the activation of kinase, whereas the phosphorylation of threonine in the T-loop is essential for activation.", "output": {"entities": {"gene": [{"text": "Cdks", "start": 15, "end": 19}]}}, "schema": []}
{"input": "We also report that AHR interacts with COUP-TF in transfected CV-1 cells.", "output": {"entities": {"gene": [{"text": "AHR", "start": 20, "end": 23}, {"text": "COUP-TF", "start": 39, "end": 46}]}}, "schema": []}
{"input": "AB004534.", "output": {"entities": {"gene": [{"text": "AB004534", "start": 0, "end": 8}]}}, "schema": []}
{"input": "The prevalence of hepatitis C virus (HCV) infection is relatively low in childhood, with anti-HCV prevalence rates of 0. 1-0. 4% in the Western world.", "output": {"entities": {"gene": [{"text": "anti-HCV", "start": 89, "end": 97}]}}, "schema": []}
{"input": "Clear and evidenced-based information should be provided to patients as to the means of prevention with special attention to individual risk groups such as IV drug abusers.", "output": {"entities": {}}, "schema": []}
{"input": "During latency, more than 1% of neurons in ganglia that innervate the footpad expressed beta-galactosidase, with the number of positive cells remaining constant for at least 5 months.", "output": {"entities": {"gene": [{"text": "beta-galactosidase", "start": 88, "end": 106}]}}, "schema": []}
{"input": "As an alternative approach to this question, we have studied the effects of ectopically expressed SHIP, SHP-1, or SHP-2 SH2-containing decoy proteins on Fc gamma RIIB1 signaling.", "output": {"entities": {"gene": [{"text": "SHIP", "start": 98, "end": 102}, {"text": "SHP-1", "start": 104, "end": 109}, {"text": "SHP-2", "start": 114, "end": 119}, {"text": "Fc gamma RIIB1", "start": 153, "end": 167}]}}, "schema": []}
{"input": "Compared to those with normal renal functions, these patients were older (P < or = 0. 01), had significantly elevated blood pressures (P < 0. 01 or P = 0. 0001), and in the case of Type 1 DM, with a higher body mass index (P = 0. 0001) and waist-hip ratio (P < 0. 01).", "output": {"entities": {}}, "schema": []}
{"input": "In all tissues examined only transcripts positive for insert 3, an 18 bp insertion in repeat 21, were amplified, even under conditions in which a 30% level of insert 3 negative transcript could be easily detected in artificially prepared control samples.", "output": {"entities": {}}, "schema": []}
{"input": "These results show that the CAAT-region is involved in upregulating the MDR1 promoter in HL60/VCR cells.", "output": {"entities": {"gene": [{"text": "MDR1 promoter", "start": 72, "end": 85}]}}, "schema": []}
{"input": "Both receptors utilize protein tyrosine kinases (PTKs) for the phosphorylation of various signaling molecules, a process that is critical for the function of both receptors.", "output": {"entities": {"gene": [{"text": "protein tyrosine kinases", "start": 23, "end": 47}, {"text": "PTKs", "start": 49, "end": 53}]}}, "schema": []}
{"input": "The synergistic effect due to the 5'-3' cooperation was at least fourfold greater than the sum of the contributions of the individual UTRs.", "output": {"entities": {}}, "schema": []}
{"input": "We demonstrate that both R and Z activate the cellular stress mitogen-activated protein (MAP) kinases, p38 and JNK, resulting in phosphorylation (and activation) of the cellular transcription factor ATF2.", "output": {"entities": {"gene": [{"text": "R", "start": 25, "end": 26}, {"text": "Z", "start": 31, "end": 32}, {"text": "mitogen-activated protein (MAP) kinases", "start": 62, "end": 101}, {"text": "p38", "start": 103, "end": 106}, {"text": "JNK", "start": 111, "end": 114}, {"text": "cellular transcription factor ATF2", "start": 169, "end": 203}]}}, "schema": []}
{"input": "Anatomy of the uterine artery.", "output": {"entities": {}}, "schema": []}
{"input": "However, activation of the cAMP pathway, which is known to regulate inhibin alpha expression, greatly enhanced the actions of SF-1.", "output": {"entities": {"gene": [{"text": "inhibin alpha", "start": 68, "end": 81}, {"text": "SF-1", "start": 126, "end": 130}]}}, "schema": []}
{"input": "Deletion and site-directed mutagenesis localized a novel SF-1 regulatory element (TCA GGGCCA;-137 to-129) adjacent to a variant cAMP-response element (CRE;-120 to-114).", "output": {"entities": {"gene": [{"text": "SF-1 regulatory element", "start": 57, "end": 80}]}}, "schema": []}
{"input": "Synthetic ligands have been identified that reset and amplify the cycle of pulsatile GH secretion by interacting with the orphan GH-secretagogue receptor (GHS-R).", "output": {"entities": {"gene": [{"text": "GH", "start": 85, "end": 87}, {"text": "orphan GH-secretagogue receptor", "start": 122, "end": 153}, {"text": "GHS-R", "start": 155, "end": 160}]}}, "schema": []}
{"input": "The collection of mutants displaying TGN sorting defects includes members with mutations in previously identified vacuolar protein sorting genes (VPS), including the dynamin family member VPS1.", "output": {"entities": {"gene": [{"text": "vacuolar protein sorting genes", "start": 114, "end": 144}, {"text": "VPS", "start": 146, "end": 149}, {"text": "dynamin", "start": 166, "end": 173}, {"text": "VPS1", "start": 188, "end": 192}]}}, "schema": []}
{"input": "Also in the spectrum of mutants with TGN sorting defects are isolates with mutations in the following: RIC1, encoding a product originally proposed to participate in ribosome biogenesis; LUV1, encoding a product potentially involved in vacuole and microtubule organization; and INP53, encoding a synaptojanin-like inositol polyphosphate 5-phosphatase.", "output": {"entities": {"gene": [{"text": "RIC1", "start": 103, "end": 107}, {"text": "LUV1", "start": 187, "end": 191}, {"text": "INP53", "start": 278, "end": 283}, {"text": "synaptojanin-like inositol polyphosphate 5-phosphatase", "start": 296, "end": 350}]}}, "schema": []}
{"input": "The single strandedness is manifested as a terminal extension of the G-rich strand (G tails) that can occur independently of telomerase, suggesting that cdc17/pol1 mutants exhibit defects in telomeric lagging-strand synthesis.", "output": {"entities": {"gene": [{"text": "telomerase", "start": 125, "end": 135}, {"text": "cdc17", "start": 153, "end": 158}, {"text": "pol1", "start": 159, "end": 163}]}}, "schema": []}
{"input": "In addition, CaMig1 formed specific complexes with the URS1 region of the S. cerevisiae FBP1 gene.", "output": {"entities": {"gene": [{"text": "CaMig1", "start": 13, "end": 19}, {"text": "S. cerevisiae FBP1 gene", "start": 74, "end": 97}]}}, "schema": []}
{"input": "Furthermore, the wide distribution of the GFP-POLO protein to all compartments of the mitotic apparatus provides a valuable tool for future studies on cell cycle during development.", "output": {"entities": {"gene": [{"text": "GFP", "start": 42, "end": 45}, {"text": "POLO", "start": 46, "end": 50}]}}, "schema": []}
{"input": "An ASIC-chip for stereoscopic depth analysis in video-real-time based on visual cortical cell behavior.", "output": {"entities": {}}, "schema": []}
{"input": "However, calphostin C, a specific inhibitor of PKC, abolished the TPA-induced increase in CFI mRNA levels.", "output": {"entities": {"gene": [{"text": "PKC", "start": 47, "end": 50}, {"text": "CFI mRNA", "start": 90, "end": 98}]}}, "schema": []}
{"input": "Preimmune IgG, anti-GalT Fab fragments, irrelevant polymers and monomeric N-acetylglucosamine had no effect.", "output": {"entities": {"gene": [{"text": "Preimmune IgG", "start": 0, "end": 13}, {"text": "anti-GalT Fab fragments", "start": 15, "end": 38}]}}, "schema": []}
{"input": "Downstream of the G-A anastomosis, the RD, CC, E (p) and loop areas were significantly different from REF, but significantly different from A-A.", "output": {"entities": {}}, "schema": []}
{"input": "Induced expression of c-myc is likely to contribute to the proliferation of Stat1-null cells in response to IFNs.", "output": {"entities": {"gene": [{"text": "c-myc", "start": 22, "end": 27}, {"text": "Stat1", "start": 76, "end": 81}, {"text": "IFNs", "start": 108, "end": 112}]}}, "schema": []}
{"input": "Eastern Cooperative Oncology Group trial E3186 was initiated to explore this question.", "output": {"entities": {}}, "schema": []}
{"input": "We determined how DNA repair is affected by TFA1 conditional mutations.", "output": {"entities": {"gene": [{"text": "TFA1", "start": 44, "end": 48}]}}, "schema": []}
{"input": "These articles both report the results of multi-institutional, randomized, phase 3 trials for the treatment of patients with localized (T1-3 N0-1 M0) esophageal squamous cell carcinoma (SCC) or esophageal adenocarcinoma.", "output": {"entities": {}}, "schema": []}
{"input": "Studies of MPO gene regulation can help to elucidate the mechanism of normal and abnormal myeloid differentiation.", "output": {"entities": {"gene": [{"text": "MPO gene", "start": 11, "end": 19}]}}, "schema": []}
{"input": "NDRF/NeuroD2 was co-precipitated with PKN from the lysate of COS-7 cells transfected with both expression constructs for NDRF/NeuroD2 and PKN.", "output": {"entities": {"gene": [{"text": "NDRF", "start": 0, "end": 4}, {"text": "NeuroD2", "start": 5, "end": 12}, {"text": "PKN", "start": 38, "end": 41}, {"text": "NDRF", "start": 121, "end": 125}, {"text": "NeuroD2", "start": 126, "end": 133}, {"text": "PKN", "start": 138, "end": 141}]}}, "schema": []}
{"input": "Transient transfection assays using P19 cells revealed that expression of NDRF/NeuroD2 increased the transactivation of the rat insulin promoter element 3 (RIPE3) enhancer up to approximately 12-fold and that co-expression of catalytically active form of PKN, but not kinase-deficient derivative, resulted in a further threefold increase of NDRF/NeuroD2-mediated transcription.", "output": {"entities": {"gene": [{"text": "NDRF", "start": 74, "end": 78}, {"text": "NeuroD2", "start": 79, "end": 86}, {"text": "rat insulin promoter element 3", "start": 124, "end": 154}, {"text": "RIPE3", "start": 156, "end": 161}, {"text": "PKN", "start": 255, "end": 258}, {"text": "NDRF", "start": 341, "end": 345}, {"text": "NeuroD2", "start": 346, "end": 353}]}}, "schema": []}
{"input": "Two Pax2/5/8-binding sites in Engrailed2 are required for proper initiation of endogenous mid-hindbrain expression.", "output": {"entities": {"gene": [{"text": "Pax2/5/8-binding sites", "start": 4, "end": 26}, {"text": "Engrailed2", "start": 30, "end": 40}]}}, "schema": []}
{"input": "AF154055.", "output": {"entities": {"gene": [{"text": "AF154055", "start": 0, "end": 8}]}}, "schema": []}
{"input": "Alignment of the cervical spine, vertebral abnormalities, and disc changes also were evaluated.", "output": {"entities": {}}, "schema": []}
{"input": "The concomitant interaction of mSTI1 with hsp70 and hsp90 at its N-and C-termini respectively is mediated by the tetratricopeptide repeat (TPR) motifs in these regions.", "output": {"entities": {"gene": [{"text": "mSTI1", "start": 31, "end": 36}, {"text": "hsp70", "start": 42, "end": 47}, {"text": "hsp90", "start": 52, "end": 57}]}}, "schema": []}
{"input": "Competition experiments demonstrate a negative allosteric relationship between these RGD recognition sites.", "output": {"entities": {}}, "schema": []}
{"input": "Sequence analysis showed that the 5'-flanking region upstream to the ATG codon did not contain a conventional TATA box.", "output": {"entities": {}}, "schema": []}
{"input": "After i. v. administration of 500 mg acetazolamide and disinfection of the conjunctiva, 50 micrograms rt-PA in 0. 1 ml (BSS) and 0. 5 ml SF6 were injected intravitreally.", "output": {"entities": {"gene": [{"text": "rt-PA", "start": 102, "end": 107}]}}, "schema": []}
{"input": "Differential expression and regulation by 20-hydroxyecdysone of mosquito ultraspiracle isoforms.", "output": {"entities": {}}, "schema": []}
{"input": "The three isoforms purified with anti-FLAG antibody affinity column transferred sulfate to heparan sulfate and heparin but not to other glycosaminoglycans.", "output": {"entities": {"gene": [{"text": "anti-FLAG antibody", "start": 33, "end": 51}]}}, "schema": []}
{"input": "The differentiation and maintenance of a neurotransmitter phenotype is guided by the interaction of exogenous cues with intrinsic genetic machinery.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of functional domains of Arix reveals an N-terminal activation domain and a C-terminal repression domain.", "output": {"entities": {"gene": [{"text": "Arix", "start": 34, "end": 38}]}}, "schema": []}
{"input": "BACKGROUND: Left ventricular hypertrophy is a heterogeneous disorder with distinct morphologies.", "output": {"entities": {}}, "schema": []}
{"input": "Multivariate predictors were concentric remodeling (P < 0. 0001; odds ratio, 13. 5), left ventricular ejection fraction > 2 SD above normal (P < 0. 0001), and single-vessel left circumflex disease (P < 0. 0007; odds ratio, 7. 6).", "output": {"entities": {}}, "schema": []}
{"input": "Overexpression of ICBP90 in COS-1-transfected cells induced an enhanced expression of endogenous topoisomerase IIalpha.", "output": {"entities": {"gene": [{"text": "ICBP90", "start": 18, "end": 24}, {"text": "endogenous topoisomerase IIalpha", "start": 86, "end": 118}]}}, "schema": []}
{"input": "The RNA aptamer contains three stems separated by a pair of two-base bulges, and adopts an unanticipated fold in which both junctional sites are anchored through base triple formation.", "output": {"entities": {}}, "schema": []}
{"input": "The study suggests the presence of an anatomical sphincter at the RSJ which seems to regulate the passage of stools from the sigmoid colon to the rectum.", "output": {"entities": {}}, "schema": []}
{"input": "To quantify any mechanical inhibitory effect of nasal intermittent positive pressure ventilation (IPPV) on inspiratory activity of the diaphragm we ventilated five conscious relaxed subjects on two occasions at respiratory rates similar to quiet breathing (QB) and at three levels of applied pressure (Pappl)--6, 9 and 12 cmH2O, each during hypocapnia (P (CO2) allowed to decrease) and eucapnia (CO2 added to inspired gas).", "output": {"entities": {}}, "schema": []}
{"input": "METHODS: Von Willebrand factor (vWF) and the fibrinolytic factors tissue plasminogen activator (tPA), measured as tPA capacity, and plasminogen activator inhibitor 1 (PAI-1), platelets, fibrinogen, and inflammatory markers were measured in 74 patients with active seropositive RA.", "output": {"entities": {"gene": [{"text": "Von Willebrand factor", "start": 9, "end": 30}, {"text": "vWF", "start": 32, "end": 35}, {"text": "tissue plasminogen activator", "start": 66, "end": 94}, {"text": "tPA", "start": 96, "end": 99}, {"text": "tPA", "start": 114, "end": 117}, {"text": "plasminogen activator inhibitor 1", "start": 132, "end": 165}, {"text": "PAI-1", "start": 167, "end": 172}, {"text": "fibrinogen", "start": 186, "end": 196}]}}, "schema": []}
{"input": "Neuronal signaling properties are largely determined by the quantity and combination of ion channels expressed.", "output": {"entities": {}}, "schema": []}
{"input": "Treatment also led to a significant dose dependent reduction in the sum of ST segment depression at both trough and peak concentrations.", "output": {"entities": {}}, "schema": []}
{"input": "We have investigated the contribution of specific TATA-binding protein (TBP)-TATA interactions to the promoter activity of a constitutively expressed silkworm tRNA (C) (Ala) gene and have also asked whether the lack of similar interactions accounts for the low promoter activity of a silk gland-specific tRNA (SG) (Ala) gene.", "output": {"entities": {"gene": [{"text": "TATA-binding protein", "start": 50, "end": 70}, {"text": "TBP", "start": 72, "end": 75}, {"text": "silkworm tRNA (C) (Ala) gene", "start": 150, "end": 178}, {"text": "silk gland-specific tRNA (SG) (Ala) gene", "start": 284, "end": 324}]}}, "schema": []}
{"input": "The sequences showed extensive homologies with squalene synthase genes and enzymes from a number of other organisms and extreme amino acid conservation within the binding and catalytic domains.", "output": {"entities": {"gene": [{"text": "squalene synthase genes", "start": 47, "end": 70}]}}, "schema": []}
{"input": "Two episodes of peritonitis occurred while the patient received CAPD (1 episode/3. 5 patient-months).", "output": {"entities": {}}, "schema": []}
{"input": "Copyright 2000 The Royal College of Radiologists.", "output": {"entities": {}}, "schema": []}
{"input": "Two estrogen receptor (ER) isoforms with different estrogen dependencies are generated from the trout ER gene.", "output": {"entities": {"gene": [{"text": "estrogen receptor", "start": 4, "end": 21}, {"text": "ER", "start": 23, "end": 25}, {"text": "trout ER gene", "start": 96, "end": 109}]}}, "schema": []}
{"input": "Induction was reversed by coexpression of A-Fos, a dominant negative to AP-1.", "output": {"entities": {"gene": [{"text": "A-Fos", "start": 42, "end": 47}, {"text": "AP-1", "start": 72, "end": 76}]}}, "schema": []}
{"input": "In myometrial SMC, both isoforms of the progesterone receptor, PR-B and PR-A, caused a ligand-dependent activation of PGDH-2368/luc3.", "output": {"entities": {"gene": [{"text": "progesterone receptor", "start": 40, "end": 61}, {"text": "PR-B", "start": 63, "end": 67}, {"text": "PR-A", "start": 72, "end": 76}, {"text": "PGDH-2368", "start": 118, "end": 127}, {"text": "luc3", "start": 128, "end": 132}]}}, "schema": []}
{"input": "Element B (-249/-229) shows more than 80% homology to a consensus c-myb element, but formed two specific complexes that differed from that of c-myb in the electrophoretic mobility shift assay.", "output": {"entities": {"gene": [{"text": "consensus c-myb element", "start": 56, "end": 79}, {"text": "c-myb", "start": 142, "end": 147}]}}, "schema": []}
{"input": "Stable transfection of the truncated reduced folate carrier cDNA into mouse L1210 leukemia cells: increased folate accumulation, decreased their leucovorin and folic acid growth requirements, and increased their sensitivity to methotrexate.", "output": {"entities": {"gene": [{"text": "reduced folate carrier cDNA", "start": 37, "end": 64}]}}, "schema": []}
{"input": "Characterization of a human alternatively spliced truncated reduced folate carrier increasing folate accumulation in parental leukemia cells.", "output": {"entities": {"gene": [{"text": "human alternatively spliced truncated reduced folate carrier", "start": 22, "end": 82}]}}, "schema": []}
{"input": "Electron microscopic and enzymatic analyses revealed that the A118 genome is a linear, circularly permuted, terminally redundant collection of double-stranded DNA molecules.", "output": {"entities": {}}, "schema": []}
{"input": "Moreover, increasing the dosage of wild-type Fus3 intensifies the inhibition of both Ty1 transposition and invasive growth.", "output": {"entities": {"gene": [{"text": "wild-type Fus3", "start": 35, "end": 49}, {"text": "Ty1", "start": 85, "end": 88}]}}, "schema": []}
{"input": "Consistently, activation of c-Jun N-terminal kinase downstream of Rho family GTP-binding proteins was also enhanced when Dbl was tyrosine-phosphorylated.", "output": {"entities": {"gene": [{"text": "c-Jun N-terminal kinase", "start": 28, "end": 51}, {"text": "Rho family GTP-binding proteins", "start": 66, "end": 97}, {"text": "Dbl", "start": 121, "end": 124}]}}, "schema": []}
{"input": "However, its participation in collagen binding has not been shown.", "output": {"entities": {"gene": [{"text": "collagen", "start": 30, "end": 38}]}}, "schema": []}
{"input": "Together, these data suggest that the carboxyl terminus of CFTR contains a tyrosine-based internalization signal that interacts with the endocytic adaptor complex AP-2 to facilitate efficient entry of CFTR into clathrin-coated vesicles.", "output": {"entities": {"gene": [{"text": "CFTR", "start": 59, "end": 63}, {"text": "AP-2", "start": 163, "end": 167}, {"text": "CFTR", "start": 201, "end": 205}, {"text": "clathrin", "start": 211, "end": 219}]}}, "schema": []}
{"input": "The insulin therapy regimen did not affect the evolution of the patients and no significant relationship existed between the age at diagnosis, duration of diabetes, daily insulin dosage or metabolic control and height or BMI.", "output": {"entities": {"gene": [{"text": "insulin", "start": 4, "end": 11}, {"text": "insulin", "start": 171, "end": 178}]}}, "schema": []}
{"input": "Scmh1 maps to 4D1-D2. 1 in mice.", "output": {"entities": {"gene": [{"text": "Scmh1", "start": 0, "end": 5}]}}, "schema": []}
{"input": "The applicability of laparoscopic donor nephrectomy (LDN) has not been assessed in the obese donor.", "output": {"entities": {}}, "schema": []}
{"input": "Hyaluronan treatment stimulated collagen remodeling in the peripheral region and inhibited swelling of the meniscus repaired in the inner region.", "output": {"entities": {"gene": [{"text": "collagen", "start": 32, "end": 40}]}}, "schema": []}
{"input": "We have addressed these issues by reconstituting and characterizing the KRAB: KAP-1-RBCC interaction using purified components.", "output": {"entities": {"gene": [{"text": "KRAB", "start": 72, "end": 76}, {"text": "KAP-1", "start": 78, "end": 83}, {"text": "RBCC", "start": 84, "end": 88}]}}, "schema": []}
{"input": "The RING finger, B2 box, and coiled-coil region are required for oligomerization of KAP-1-RBCC and KRAB binding, as mutations in these domains concomitantly abolished these functions.", "output": {"entities": {"gene": [{"text": "KAP-1", "start": 84, "end": 89}, {"text": "RBCC", "start": 90, "end": 94}, {"text": "KRAB", "start": 99, "end": 103}]}}, "schema": []}
{"input": "JPEG 53, resulting in a compression ratio of 1: 21, does not compromise the diagnostic performance in general.", "output": {"entities": {}}, "schema": []}
{"input": "We critically assess current systematic uncertainties and determine the primordial Li abundance within new, much tighter limits: & amp; parl0; Li & amp; solm0; H & amp; parr0; p = 1. 23 + 0. 68-0. 32x10-10.", "output": {"entities": {}}, "schema": []}
{"input": "Like their yeast counterpart, the mouse GCN2 isoforms contain HisRS-related sequences juxtaposed to the kinase catalytic domain.", "output": {"entities": {"gene": [{"text": "GCN2", "start": 40, "end": 44}, {"text": "HisRS-related sequences", "start": 62, "end": 85}]}}, "schema": []}
{"input": "Five women (15. 6%) met criteria for PMS.", "output": {"entities": {}}, "schema": []}
{"input": "MBI and MMBI showed similar Cmax values, but the former disappeared slower in the serum than the latter and resulted in its larger AUC values.", "output": {"entities": {}}, "schema": []}
{"input": "Another long insertion in the cathepsin X amino acid sequence forms a beta-hairpin pointing away from the active site.", "output": {"entities": {"gene": [{"text": "cathepsin X amino acid sequence", "start": 30, "end": 61}]}}, "schema": []}
{"input": "Transfection experiments demonstrated that the 5'-flanking region (-1894 to + 37) of the mStaf gene drives transcription in mouse NMuMG cells and that a construct containing a fragment from-387 to + 37 showed the highest transcriptional activity.", "output": {"entities": {"gene": [{"text": "mStaf gene", "start": 89, "end": 99}]}}, "schema": []}
{"input": "Further studies in T-24 cells demonstrated that HA fragments also induced I kappa B alpha phosphorylation and degradation, kappa B-linked reporter gene expression, and ICAM-1 promoter activity in an NF-kappa B-dependent manner.", "output": {"entities": {"gene": [{"text": "I kappa B alpha", "start": 74, "end": 89}, {"text": "kappa B-linked reporter gene", "start": 123, "end": 151}, {"text": "ICAM-1 promoter", "start": 168, "end": 183}, {"text": "NF-kappa B", "start": 199, "end": 209}]}}, "schema": []}
{"input": "Pretreatment of cells or mouse skin with antisense oligonucleotides of PKCzeta impaired UV-induced activation of AP-1 in JB6 cells as well as in AP-1-luciferase transgenic mice.", "output": {"entities": {"gene": [{"text": "PKCzeta", "start": 71, "end": 78}, {"text": "AP-1", "start": 113, "end": 117}, {"text": "AP-1", "start": 145, "end": 149}, {"text": "luciferase", "start": 150, "end": 160}]}}, "schema": []}
{"input": "The level of subclinical infection was 75% among seropositive dogs.", "output": {"entities": {}}, "schema": []}
{"input": "Desmethylferrochloroquine 1a and didesmethylferrochloroquine 2 would be more potent against schizontocides than CQ in vitro against two strains (HB3 and Dd2) of Plasmodium falciparum.", "output": {"entities": {}}, "schema": []}
{"input": "The rrd1, 2delta mutant was partially rescued by inactivation of HOG1 or PBS2, suggesting an interaction between the RRD genes and the Hog1p signal transduction pathway.", "output": {"entities": {"gene": [{"text": "rrd1, 2delta mutant", "start": 4, "end": 23}, {"text": "HOG1", "start": 65, "end": 69}, {"text": "PBS2", "start": 73, "end": 77}, {"text": "RRD genes", "start": 117, "end": 126}, {"text": "Hog1p signal transduction pathway", "start": 135, "end": 168}]}}, "schema": []}
{"input": "Members of the JAK/Tyk family of tyrosine kinases mediate phosphorylation of STAT3 at Tyr705 during CNTF signaling; however, the kinase responsible for phosphorylation at STAT3 Tyr727 appears to depend on both the extracellular stimulus and the cellular context.", "output": {"entities": {"gene": [{"text": "JAK", "start": 15, "end": 18}, {"text": "Tyk", "start": 19, "end": 22}, {"text": "tyrosine kinases", "start": 33, "end": 49}, {"text": "STAT3", "start": 77, "end": 82}, {"text": "CNTF", "start": 100, "end": 104}, {"text": "STAT3", "start": 171, "end": 176}]}}, "schema": []}
{"input": "In vivo, CARbeta/RXRalpha activated transcription from an HD-PPRE luciferase reporter construct.", "output": {"entities": {"gene": [{"text": "CARbeta", "start": 9, "end": 16}, {"text": "RXRalpha", "start": 17, "end": 25}, {"text": "HD", "start": 58, "end": 60}, {"text": "luciferase reporter construct", "start": 66, "end": 95}]}}, "schema": []}
{"input": "Thus, SOX8 is a good candidate gene contributing to the mental retardation phenotype seen in ATR-16 patients.", "output": {"entities": {"gene": [{"text": "SOX8", "start": 6, "end": 10}]}}, "schema": []}
{"input": "Patch test results obtained with corticosteroid allergic patients tested with a large corticosteroid series validated the earlier classification of corticosteroid molecules in four groups of cross-reacting molecules: i. e., group A (hydrocortisone type), group B (acetonides), group C (betamethasone type-non esterified) and group D (esters).", "output": {"entities": {}}, "schema": []}
{"input": "An increase in the level of serum enzymes, such as aspartate transaminase, alkaline phosphatase, creatine phosphokinase, lactate dehydrogenase after D. russelli venom injection in albino rats is indicative of cell or tissue damage.", "output": {"entities": {"gene": [{"text": "aspartate transaminase", "start": 51, "end": 73}, {"text": "alkaline phosphatase", "start": 75, "end": 95}, {"text": "creatine phosphokinase", "start": 97, "end": 119}, {"text": "lactate dehydrogenase", "start": 121, "end": 142}]}}, "schema": []}
{"input": "The partial farm budget highlighted the importance of reducing sub-clinical lesions in a feedlot.", "output": {"entities": {}}, "schema": []}
{"input": "Surprisingly, 3 full-length murine survivin cDNA clones were isolated, predicting the existence of 3 distinct survivin proteins.", "output": {"entities": {"gene": [{"text": "full-length murine survivin cDNA", "start": 16, "end": 48}, {"text": "survivin proteins", "start": 110, "end": 127}]}}, "schema": []}
{"input": "Thus, the induction of E2F binding to the E2F-1 promoter by the E4-6/7 protein observed in vitro correlates with transactivation of E2F-1 promoter activity in vivo.", "output": {"entities": {"gene": [{"text": "E2F", "start": 23, "end": 26}, {"text": "E2F-1 promoter", "start": 42, "end": 56}, {"text": "E4-6/7 protein", "start": 64, "end": 78}, {"text": "E2F-1 promoter", "start": 132, "end": 146}]}}, "schema": []}
{"input": "We show that stabilization of the hairpin reduced the amount of tRNA primer that is annealed to the PBS.", "output": {"entities": {}}, "schema": []}
{"input": "Ischemia-induced biphasic arrhythmias were suppressed in both zatebradine and propranolol groups.", "output": {"entities": {}}, "schema": []}
{"input": "ZK7 and HZF16 genes appear to be the splice variants transcribed from the same gene.", "output": {"entities": {"gene": [{"text": "ZK7", "start": 0, "end": 3}, {"text": "HZF16 genes", "start": 8, "end": 19}]}}, "schema": []}
{"input": "CONCLUSION: Presence of APOE epsilon4/* seems to increase the risk for dementia and AD independently of its effect on dyslipidemia and atherogenesis.", "output": {"entities": {"gene": [{"text": "APOE epsilon4/*", "start": 24, "end": 39}]}}, "schema": []}
{"input": "No definite conclusions are possible because of the small number of patients involved in this phase II trial.", "output": {"entities": {}}, "schema": []}
{"input": "Two distinct Salmonella fimbrins, AgfA and SefA, comprising thin aggregative fimbriae SEF17 and SEF14, respectively, were each genetically engineered to carry PT3, an alpha-helical 16-amino acid Leishmania T-cell epitope derived from the metalloprotease gp63.", "output": {"entities": {"gene": [{"text": "Salmonella fimbrins", "start": 13, "end": 32}, {"text": "AgfA", "start": 34, "end": 38}, {"text": "SefA", "start": 43, "end": 47}, {"text": "SEF17", "start": 86, "end": 91}, {"text": "SEF14", "start": 96, "end": 101}, {"text": "PT3", "start": 159, "end": 162}, {"text": "metalloprotease gp63", "start": 238, "end": 258}]}}, "schema": []}
{"input": "In marked contrast to AgfA, none of the chimeric SefA proteins were expressed or assembled into fimbriae.", "output": {"entities": {"gene": [{"text": "AgfA", "start": 22, "end": 26}, {"text": "chimeric SefA proteins", "start": 40, "end": 62}]}}, "schema": []}
{"input": "Productive growth of phage P22 in wild-type Salmonella typhimurium correlates with the presence of Abc2, but is independent of the absolute level of ATP-dependent nuclease activity, suggesting a qualitative change in the nature of Abc2-modified RecBCD nuclease activity relative to the native enzyme.", "output": {"entities": {"gene": [{"text": "Abc2", "start": 99, "end": 103}, {"text": "ATP-dependent nuclease", "start": 149, "end": 171}, {"text": "Abc2", "start": 231, "end": 235}, {"text": "RecBCD nuclease", "start": 245, "end": 260}]}}, "schema": []}
{"input": "In this study, we investigated the molecular mechanisms underlying the inducible expression of the flt-1 gene during the activation of THP-1 cells.", "output": {"entities": {"gene": [{"text": "flt-1 gene", "start": 99, "end": 109}]}}, "schema": []}
{"input": "There was a 2. 4-fold difference in CAT produced from these transcripts in HeLa cells, which contain a greater natural abundance of PTB.", "output": {"entities": {"gene": [{"text": "CAT", "start": 36, "end": 39}, {"text": "PTB", "start": 132, "end": 135}]}}, "schema": []}
{"input": "Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation.", "output": {"entities": {"gene": [{"text": "mitogen-activated protein kinase", "start": 9, "end": 41}, {"text": "cot oncoprotein", "start": 73, "end": 88}, {"text": "c-jun promoter", "start": 96, "end": 110}]}}, "schema": []}
{"input": "4.", "output": {"entities": {}}, "schema": []}
{"input": "In the present study we have investigated the regulatory mechanism for CD95L expression.", "output": {"entities": {"gene": [{"text": "CD95L", "start": 71, "end": 76}]}}, "schema": []}
{"input": "Protein sequence analysis reveals that MAN1 shares a conserved globular domain of approximately 40 amino acids, which we term the LEM module, with inner nuclear membrane proteins lamina-associated polypeptide 2 and emerin.", "output": {"entities": {"gene": [{"text": "MAN1", "start": 39, "end": 43}, {"text": "LEM module", "start": 130, "end": 140}, {"text": "lamina-associated polypeptide 2", "start": 179, "end": 210}, {"text": "emerin", "start": 215, "end": 221}]}}, "schema": []}
{"input": "The encoded amino acid sequences in the full-length bovine and porcine cDNAs were identical, consisting of 209 amino acid residues, and were nearly the same as the published sequence determined by Edman degradation.", "output": {"entities": {}}, "schema": []}
{"input": "With chemical shift imaging, the signal intensity decreased on the out-of-phase images in six of seven (86%) patients with APA and in eight of nine (89%) patients with BAH.", "output": {"entities": {}}, "schema": []}
{"input": "For each night, the diary allowed the subjective measurement of bedtime, wake time, time in bed (TIB), sleep efficiency, number of minutes of wake after sleep onset (WASO), alertness on awakening, and percentage of morning needing an alarm (or a person functioning as one).", "output": {"entities": {}}, "schema": []}
{"input": "Acad.", "output": {"entities": {}}, "schema": []}
{"input": "Copyright 2000 Academic Press.", "output": {"entities": {}}, "schema": []}
{"input": "These data suggest that combined lesions of cholinergic and serotonergic neurons in the rat brain do not alter olfactory perception or olfactory short-term memory.", "output": {"entities": {}}, "schema": []}
{"input": "Extreme potency of botulinum toxin.", "output": {"entities": {"gene": [{"text": "botulinum toxin", "start": 19, "end": 34}]}}, "schema": []}
{"input": "In contrast, c-Src activated by isoproterenol led to tyrosine phosphorylation of Shc and subsequent Erk activation, but not tyrosine phosphorylation of cortactin or Stat3.", "output": {"entities": {"gene": [{"text": "c-Src", "start": 13, "end": 18}, {"text": "Shc", "start": 81, "end": 84}, {"text": "Erk", "start": 100, "end": 103}, {"text": "cortactin", "start": 152, "end": 161}, {"text": "Stat3", "start": 165, "end": 170}]}}, "schema": []}
{"input": "For wild type MutT and its E53D and E44D mutants, plots of log (k (cat)) versus pH exhibited a limiting slope of 1 on the ascending limb and then a hump, i. e., a sharply defined maximum near pH 8 followed by a plateau, yielding apparent pK (a) values of 7. 6 +/-0. 3 and 8. 4 +/-0. 4 for an essential base and a nonessential acid catalyst, respectively, in the active quaternary MutT-Mg (2 +)-dGTP-Mg (2 +) complex.", "output": {"entities": {"gene": [{"text": "MutT", "start": 14, "end": 18}, {"text": "E53D", "start": 27, "end": 31}, {"text": "E44D mutants", "start": 36, "end": 48}, {"text": "MutT", "start": 380, "end": 384}]}}, "schema": []}
{"input": "Structural changes in the kinetically more damaged E44D mutant detected in (1) H-(15) N HSQC spectra were largely limited to the loop I-helix I motif, suggesting that Glu-44 stabilizes the active site region.", "output": {"entities": {}}, "schema": []}
{"input": "In vitro expression of four different naturally occurring nonsense and missense mutations revealed a dramatically altered subcellular location of the protein in cultured cells.", "output": {"entities": {}}, "schema": []}
{"input": "After i. v.", "output": {"entities": {}}, "schema": []}
{"input": "Immunity acquired by mice during I. scapularis nymphal activity in early summer may exclude a large proportion of the mouse population from maintaining E. phagocytophila during the period of larval activity later in the season.", "output": {"entities": {}}, "schema": []}
{"input": "The emerging view based on studies in yeast is that each class of snoRNPs is composed of a unique set of proteins.", "output": {"entities": {}}, "schema": []}
{"input": "BCR cross-linking also led to increased MAPK-activated protein kinase-2 activity, an enzyme that lies immediately downstream from p38 MAPK; MAPK-activated protein kinase-2 immune complexes phosphorylated a peptide substrate containing the CREB serine 133 phosphoacceptor motif.", "output": {"entities": {"gene": [{"text": "BCR", "start": 0, "end": 3}, {"text": "MAPK", "start": 40, "end": 44}, {"text": "protein kinase-2", "start": 55, "end": 71}, {"text": "p38 MAPK", "start": 130, "end": 138}, {"text": "MAPK", "start": 140, "end": 144}, {"text": "protein kinase-2", "start": 155, "end": 171}, {"text": "CREB serine 133 phosphoacceptor motif", "start": 239, "end": 276}]}}, "schema": []}
{"input": "Activation of a CRE-dependent junB promoter/chloramphenicol acetyltransferase (CAT) reporter gene by the BCR was also blocked by SB203580.", "output": {"entities": {"gene": [{"text": "junB promoter", "start": 30, "end": 43}, {"text": "chloramphenicol acetyltransferase", "start": 44, "end": 77}, {"text": "CAT", "start": 79, "end": 82}, {"text": "BCR", "start": 105, "end": 108}]}}, "schema": []}
{"input": "We present evidence that the upstream open reading frame (uORF) represses the translation of the downstream major open reading frame (mORF).", "output": {"entities": {}}, "schema": []}
{"input": "METHODS: TBN measurements were performed in 31 female outpatients with breast carcinoma who were undergoing standard cyclophosphamide, methotrexate, and 5-fluorouracil (CMF)-based chemotherapy (median age, 48 years; range, 26-77 years).", "output": {"entities": {}}, "schema": []}
{"input": "A 385 bp Glucocorticoid Response Unit (GRU) was identified whose glucocorticoid induction was enhanced by dibutyryl-cAMP and reduced by phorbol esters.", "output": {"entities": {}}, "schema": []}
{"input": "No somatic mutations were found in any of the samples, suggesting that ING1 is not a tumor suppressor gene target in head and neck cancer.", "output": {"entities": {"gene": [{"text": "ING1", "start": 71, "end": 75}]}}, "schema": []}
{"input": "Ras-GRF1 transiently expressed with v-Src was tyrosine-phosphorylated and showed significant GEF activity toward Rac, but not Rho and Cdc42, which was comparable with that induced by Gbetagamma.", "output": {"entities": {"gene": [{"text": "Ras", "start": 0, "end": 3}, {"text": "GRF1", "start": 4, "end": 8}, {"text": "v-Src", "start": 36, "end": 41}, {"text": "GEF", "start": 93, "end": 96}, {"text": "Rac", "start": 113, "end": 116}, {"text": "Rho", "start": 126, "end": 129}, {"text": "Cdc42", "start": 134, "end": 139}, {"text": "Gbetagamma", "start": 183, "end": 193}]}}, "schema": []}
{"input": "EMSA showed that nuclear proteins from PC12 but not C6 or Rat2 cells bind the CRE as a complex containing activating transcription factor (ATF)-4 and CCAAT enhancer-binding protein beta, while both PC12 and C6 cell nuclear extracts were recruited by the CCAAT-box as a complex containing nuclear factor Y.", "output": {"entities": {"gene": [{"text": "activating transcription factor (ATF)-4", "start": 106, "end": 145}, {"text": "CCAAT enhancer-binding protein beta", "start": 150, "end": 185}, {"text": "nuclear factor Y", "start": 288, "end": 304}]}}, "schema": []}
{"input": "EMSA showed that nuclear proteins from PC12 but not C6 or Rat2 cells bind the CRE as a complex containing activating transcription factor (ATF)-4 and CCAAT enhancer-binding protein beta, while both PC12 and C6 cell nuclear extracts were recruited by the CCAAT-box as a complex containing nuclear factor Y.", "output": {"entities": {"gene": [{"text": "activating transcription factor (ATF)-4", "start": 106, "end": 145}, {"text": "CCAAT enhancer-binding protein beta", "start": 150, "end": 185}, {"text": "nuclear factor Y", "start": 288, "end": 304}]}}, "schema": []}
{"input": "Despite resolution of the solid portion of the tumor, serial MRI showed enlargement of a bilobar tumor cyst 3 years after the original diagnosis.", "output": {"entities": {}}, "schema": []}
{"input": "LPO and SOD levels were measured at five points before and during the operation.", "output": {"entities": {"gene": [{"text": "SOD", "start": 8, "end": 11}]}}, "schema": []}
{"input": "Sustained ventricular tachycardia and its successful prophylaxis during high-dose bolus interleukin-2 therapy for metastatic renal cell carcinoma.", "output": {"entities": {"gene": [{"text": "interleukin-2", "start": 88, "end": 101}]}}, "schema": []}
{"input": "Second, when the NBF1 + R protein, the NBF2 protein, and a mixture of the two proteins were folded separately and analyzed by molecular sieve chomatography, the mixture was found to elute prior to either NBF1 + R or NBF2.", "output": {"entities": {"gene": [{"text": "NBF1 + R protein", "start": 17, "end": 33}, {"text": "NBF2 protein", "start": 39, "end": 51}, {"text": "NBF1 + R", "start": 204, "end": 212}, {"text": "NBF2", "start": 216, "end": 220}]}}, "schema": []}
{"input": "Collectively, these experiments demonstrate that CFTR' s NBF1 + R region and its NBF2 domain, after folding separately as distinct units, have a strong propensity to interact and that this interaction is stable in the absence of added nucleotides or exogenously induced phosphorylation.", "output": {"entities": {"gene": [{"text": "CFTR' s NBF1 + R region", "start": 49, "end": 72}, {"text": "NBF2 domain", "start": 81, "end": 92}]}}, "schema": []}
{"input": "Copyright 2000 Academic Press.", "output": {"entities": {}}, "schema": []}
{"input": "Sulfhydryl titration with iodoacetamide, monitored by quantitating the residual thiols after reaction with a maleimide derivative of biotin, revealed a striking difference in the apparent pK (a) values of the cysteines at the two splice junctions.", "output": {"entities": {}}, "schema": []}
{"input": "After nitric oxide inhalation, the results showed moderate increases in PaO2 and SaO2 (P > 0. 05) and a significant decrease in Qs/Q tau ratio (P < 0. 01).", "output": {"entities": {}}, "schema": []}
{"input": "The results showed that MIP, MMIF, FIC, Wimax, P0. 1 and minute ventilation (Vr) were significantly increased after administration of methylphenidatum and aminophylline.", "output": {"entities": {}}, "schema": []}
{"input": "It has also been shown that a variety of extracellular factors stimulate a pair of MAPK p44 and MAPK p42 of MAPK family members.", "output": {"entities": {"gene": [{"text": "p44", "start": 88, "end": 91}, {"text": "p42", "start": 101, "end": 104}, {"text": "MAPK family members", "start": 108, "end": 127}]}}, "schema": []}
{"input": "Covalent modification of the transactivator protein IE2-p86 of human cytomegalovirus by conjugation to the ubiquitin-homologous proteins SUMO-1 and hSMT3b.", "output": {"entities": {"gene": [{"text": "IE2", "start": 52, "end": 55}, {"text": "p86", "start": 56, "end": 59}, {"text": "ubiquitin-homologous proteins SUMO-1", "start": 107, "end": 143}, {"text": "hSMT3b", "start": 148, "end": 154}]}}, "schema": []}
{"input": "73: 658-666, 1999).", "output": {"entities": {}}, "schema": []}
{"input": "The interaction between U (L) 3.", "output": {"entities": {}}, "schema": []}
{"input": "Protamine and heparin doses, their sum (Sigma-dose) and differential (Delta-dose) doses, and activated clotting times were tabulated.", "output": {"entities": {"gene": [{"text": "Protamine", "start": 0, "end": 9}]}}, "schema": []}
{"input": "In this study, a common mechanism has been identified to coordinate the growth-and FC-dependent expression of caveolin.", "output": {"entities": {"gene": [{"text": "caveolin", "start": 110, "end": 118}]}}, "schema": []}
{"input": "Comparison of the plant nuclear tRNA 3' processing enzyme with the plant mitochondrial one suggests that both activities are different enzymes.", "output": {"entities": {}}, "schema": []}
{"input": "NKX2. 1 is a member of the NK2 family of homeodomain-containing transcription factors whose targeted disruption in mouse results in the absence of thyroid tissue and a severely abnormal lung phenotype.", "output": {"entities": {"gene": [{"text": "NKX2. 1", "start": 0, "end": 7}, {"text": "NK2 family", "start": 27, "end": 37}, {"text": "homeodomain-containing transcription factors", "start": 41, "end": 85}]}}, "schema": []}
{"input": "National abortion laws usually do not allow abortion when a foetus is independently viable, i. e. from a gestational age of about 24 weeks.", "output": {"entities": {}}, "schema": []}
{"input": "Deglutition is considered to be immature in infants and to mature postnatally.", "output": {"entities": {}}, "schema": []}
{"input": "This repression does not require the PU. 1 transactivation or PEST domains and cannot be reversed by p300 expression.", "output": {"entities": {"gene": [{"text": "PU. 1", "start": 37, "end": 42}, {"text": "p300", "start": 101, "end": 105}]}}, "schema": []}
{"input": "First, human erythroid K562 cells stably integrated with various HS-40 mutants cis linked to a human alpha-globin promoter-growth hormone hybrid gene were analyzed by genomic footprinting and expression analysis.", "output": {"entities": {"gene": [{"text": "HS-40 mutants", "start": 65, "end": 78}, {"text": "human alpha-globin promoter", "start": 95, "end": 122}, {"text": "growth hormone", "start": 123, "end": 137}]}}, "schema": []}
{"input": "Interestingly, addition of purified CBP to the nuclear extracts of T47D cells markedly stimulated progesterone-and PR-dependent transcription from a nucleosome-free, progesterone response element (PRE)-linked reporter DNA template.", "output": {"entities": {"gene": [{"text": "CBP", "start": 36, "end": 39}, {"text": "PR", "start": 115, "end": 117}]}}, "schema": []}
{"input": "Its cognate binding protein, REST/NRSF, is an essential transcription factor; its null mutations result in embryonic lethality, and its dominant negative mutants produce aberrant expression of neuron-specific genes.", "output": {"entities": {"gene": [{"text": "REST", "start": 29, "end": 33}, {"text": "NRSF", "start": 34, "end": 38}]}}, "schema": []}
{"input": "Removal of all core histone tail domains by limited trypsin proteolysis or acetylation of the core histone tails significantly relieves this inhibition and allows TFIIIA to exhibit high-affinity binding to nucleosomal DNA.", "output": {"entities": {"gene": [{"text": "core histone", "start": 15, "end": 27}, {"text": "trypsin", "start": 52, "end": 59}, {"text": "core histone", "start": 94, "end": 106}, {"text": "TFIIIA", "start": 163, "end": 169}]}}, "schema": []}
{"input": "OUTCOME: Acetylcholine receptor antibodies and single-fibre electromyogram were useful in the diagnosis of myasthenia gravis.", "output": {"entities": {"gene": [{"text": "Acetylcholine receptor antibodies", "start": 9, "end": 42}]}}, "schema": []}
{"input": "Characterization of the 5'-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison withthe multidrug resistance protein 3 (MRP3) gene.", "output": {"entities": {"gene": [{"text": "human multidrug resistance protein 2", "start": 50, "end": 86}, {"text": "MRP2", "start": 88, "end": 92}, {"text": "multidrug resistance protein 3", "start": 140, "end": 170}, {"text": "MRP3", "start": 172, "end": 176}]}}, "schema": []}
{"input": "These results suggest that the M. jannaschii as well as related archaeal 20S proteasomes require a nucleotidase complex such as PAN to mediate the energy-dependent hydrolysis of folded-substrate proteins and that the N-terminal 73 amino acid residues of PAN are not absolutely required for this reaction.", "output": {"entities": {"gene": [{"text": "archaeal 20S proteasomes", "start": 64, "end": 88}, {"text": "PAN", "start": 128, "end": 131}, {"text": "PAN", "start": 254, "end": 257}]}}, "schema": []}
{"input": "The transcription factor E2F plays an important role in G (1) to S phase transition in the higher eukaryotic cell cycle.", "output": {"entities": {"gene": [{"text": "E2F", "start": 25, "end": 28}]}}, "schema": []}
{"input": "In two-field nodal dissection, two components are included with (modern two-field) or without (traditional two-field) nodal dissection around both recurrent laryngeal nerve chains in the upper mediastinum.", "output": {"entities": {}}, "schema": []}
{"input": "Of the 153 patients studied, CK-MB results were positive in 91 (59%) patients; ECG revealed AMI in 72 (47%) patients.", "output": {"entities": {"gene": [{"text": "CK-MB", "start": 29, "end": 34}]}}, "schema": []}
{"input": "The effect of MIB on the dose-response curve of externally applied noradrenaline was also studied.", "output": {"entities": {}}, "schema": []}
{"input": "The regional blockade of H1R was observed mainly in the frontal, temporal and anterior cingulate cortices, and the intravenous administration of d-chlorpheniramine as a therapeutic dose (2 mg) blocked over 60% of H1R in the frontal cortices.", "output": {"entities": {"gene": [{"text": "H1R", "start": 25, "end": 28}, {"text": "H1R", "start": 213, "end": 216}]}}, "schema": []}
{"input": "Linearized overall infection rates (events/100 patient-days) were 2. 05 +/-0. 33 (heart-lung) and 2. 34 +/-0. 34 (double-lung; P = NS) at 3 months.", "output": {"entities": {}}, "schema": []}
{"input": "Static and dynamic compliance was measured after induction of anesthesia, before and immediately after filtration in the operating theater, 1 hour after return to the pediatric intensive care unit, and 24 hours after the operation.", "output": {"entities": {}}, "schema": []}
{"input": "Antipyretic therapy: physiologic rationale, diagnostic implications, and clinical consequences.", "output": {"entities": {}}, "schema": []}
{"input": "There is no correlation between C2-C3 disk morphology and the diskographically provoked response.", "output": {"entities": {}}, "schema": []}
{"input": "KFC, a Ste20-like kinase with mitogenic potential and capability to activate the SAPK/JNK pathway.", "output": {"entities": {"gene": [{"text": "KFC", "start": 0, "end": 3}, {"text": "Ste20-like kinase", "start": 7, "end": 24}, {"text": "SAPK", "start": 81, "end": 85}, {"text": "JNK", "start": 86, "end": 89}]}}, "schema": []}
{"input": "We have mapped the human STAG3 gene to the 7q22 region of chromosome 7; six human STAG3-related genes have also been mapped: two at 7q22 near the functional gene, one at 7q11. 22, and three at 7q11. 23, two of them flanking the breakpoints commonly associated with the Williams-Beuren syndrome (WBS) deletion.", "output": {"entities": {"gene": [{"text": "human STAG3 gene", "start": 19, "end": 35}, {"text": "human STAG3-related genes", "start": 76, "end": 101}, {"text": "Williams-Beuren syndrome (WBS) deletion", "start": 269, "end": 308}]}}, "schema": []}
{"input": "Reaction time (RT) and P300 were collected simultaneously.", "output": {"entities": {}}, "schema": []}
{"input": "In experiment 2 the rats had free access to two bottles, one of which contained tap water, and the other contained either an ethanol (6%) or a sucrose (5%) solution.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, Zelen' s method is used to balance the number of patients allocated to the two groups within each institution (M.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: In this group of patients, male gender (P = 0.", "output": {"entities": {}}, "schema": []}
{"input": "Selective visual attention involves dynamic interplay between attentional control systems and sensory brain structures.", "output": {"entities": {}}, "schema": []}
{"input": "The patient had developed left-sided low-frequency tremor and hemidystonia after a severe head trauma sustained at 15 years of age.", "output": {"entities": {}}, "schema": []}
{"input": "However, the a1 isoform is expressed most heavily in brain and heart, a2 in liver and kidney, and a3 in liver, lung, heart, brain, spleen, and kidney.", "output": {"entities": {}}, "schema": []}
{"input": "During the cloning by reverse transcriptase-polymerase chain reaction of the human HIF-1alpha subunit, we isolated two cDNA clones which corresponded to alternative splicing of the HIF-1alpha gene.", "output": {"entities": {"gene": [{"text": "reverse transcriptase", "start": 22, "end": 43}, {"text": "human HIF-1alpha subunit", "start": 77, "end": 101}, {"text": "HIF-1alpha gene", "start": 181, "end": 196}]}}, "schema": []}
{"input": "To assess the relationship between G (q)/G (11) function with the phosphatidylinositol 3-kinase dependent pathway, expression of a dominant-interfering p85 regulatory subunit, as well as wortmannin treatment inhibited insulin-stimulated but not G (q)/Q209L-stimulated GLUT4-EGFP translocation.", "output": {"entities": {"gene": [{"text": "G (q)", "start": 35, "end": 40}, {"text": "G (11)", "start": 41, "end": 47}, {"text": "phosphatidylinositol 3-kinase", "start": 66, "end": 95}, {"text": "p85 regulatory subunit", "start": 152, "end": 174}, {"text": "insulin", "start": 218, "end": 225}, {"text": "G (q)/Q209L", "start": 245, "end": 256}, {"text": "GLUT4", "start": 268, "end": 273}, {"text": "EGFP", "start": 274, "end": 278}]}}, "schema": []}
{"input": "In endemic BL, the RB2/p130 gene is mutated in most of the cases, and the protein is restricted to the cytoplasm.", "output": {"entities": {"gene": [{"text": "RB2", "start": 19, "end": 22}, {"text": "p130", "start": 23, "end": 27}]}}, "schema": []}
{"input": "Together, these data identify ERK2 as a specific and direct target of HePTP and are consistent with a model in which HePTP negatively regulates ERK2 activity as part of a feedback mechanism.", "output": {"entities": {"gene": [{"text": "ERK2", "start": 30, "end": 34}, {"text": "HePTP", "start": 70, "end": 75}, {"text": "HePTP", "start": 117, "end": 122}, {"text": "ERK2", "start": 144, "end": 148}]}}, "schema": []}
{"input": "Cross-reaction between a monoclonal antibody and two alpha beta T cell receptors.", "output": {"entities": {"gene": [{"text": "alpha beta T cell receptors", "start": 53, "end": 80}]}}, "schema": []}
{"input": "Strontium nitrate mixed with glycolic acid, in comparison with glycolic acid alone, markedly (p < 0. 01) shortened the duration of the irritation sensation from 24. 4 +/-4. 1 (mean +/-SEM) min to 8. 9 +/-3. 7 (mean +/-SEM) min, and significantly (p < 0. 05) reduced the mean magnitude of the irritation sensation at all time points (overall).", "output": {"entities": {}}, "schema": []}
{"input": "The pCMBS-reactive sulfhydryl groups were located exclusively in the exofacial half of the plasma membrane and, when presented in a helical model, lie along one side of the helices.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of 1 Mb of published sequence from the region of conserved synteny on human chromosome 5q31-q33 identified 45 gene candidates, including 35 expressed genes in the human IL-4 cytokine gene cluster.", "output": {"entities": {"gene": [{"text": "human IL-4 cytokine gene cluster", "start": 172, "end": 204}]}}, "schema": []}
{"input": "Human AP-2rep repressed both reporter expression from a transiently transfected AP-2alpha promoter and the endogenous AP-2alpha gene and inversely was negatively regulated by AP-2alpha.", "output": {"entities": {"gene": [{"text": "Human AP-2rep", "start": 0, "end": 13}, {"text": "AP-2alpha promoter", "start": 80, "end": 98}, {"text": "AP-2alpha gene", "start": 118, "end": 132}, {"text": "AP-2alpha", "start": 175, "end": 184}]}}, "schema": []}
{"input": "In order to gain deeper insight into the role of the amino-terminal domain of the p24 (CA) protein during viral replication, eight highly conserved proline residues known to promote turns and to terminate alpha-helices within the p24 tertiary structure were replaced by a leucine residue (P-position-L).", "output": {"entities": {"gene": [{"text": "p24", "start": 82, "end": 85}, {"text": "CA", "start": 87, "end": 89}, {"text": "p24", "start": 230, "end": 233}]}}, "schema": []}
{"input": "Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7.", "output": {"entities": {"gene": [{"text": "Clb", "start": 0, "end": 3}, {"text": "Cdc28", "start": 4, "end": 9}, {"text": "replication initiator proteins Mcm2-7", "start": 48, "end": 85}]}}, "schema": []}
{"input": "Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish.", "output": {"entities": {"gene": [{"text": "Bozozok", "start": 21, "end": 28}, {"text": "Dharma", "start": 29, "end": 35}, {"text": "Nodal-related proteins", "start": 40, "end": 62}]}}, "schema": []}
{"input": "Thiopentone sodium administered at 30 and 10 min before or 5, 10 and 15 min after exposure to NOC-5, but not thereafter, significantly attenuated NO-induced neurotoxicity compared with controls.", "output": {"entities": {}}, "schema": []}
{"input": "We also show that zygotically activated Xretpos transcripts are restricted to ventro-posterior specific regions and induced by UV-irradiation and BMP-4 overexpression in cycloheximide-dependent way. genesis 26: 198-207, 2000.", "output": {"entities": {"gene": [{"text": "BMP-4", "start": 146, "end": 151}]}}, "schema": []}
{"input": "In all other cases, vestibular neurectomy or chemical vestibular labyrinthectomy, by means of intratympanic low concentration gentamicin (20 mg/mL), are indicated.", "output": {"entities": {}}, "schema": []}
{"input": "However, when, where and how the DSPP is cleaved into DSP and DPP is not clear.", "output": {"entities": {"gene": [{"text": "DSPP", "start": 33, "end": 37}, {"text": "DSP", "start": 54, "end": 57}, {"text": "DPP", "start": 62, "end": 65}]}}, "schema": []}
{"input": "It has a grave prognosis with > 70% mortality in 3 months, despite mechanical ventilation.", "output": {"entities": {}}, "schema": []}
{"input": "We found that TCR signaling induces AP-1 binding to this site and regulates the fasl promoter function in a fashion dependent on NF-kappaB binding.", "output": {"entities": {"gene": [{"text": "TCR", "start": 14, "end": 17}, {"text": "AP-1", "start": 36, "end": 40}, {"text": "fasl promoter", "start": 80, "end": 93}, {"text": "NF-kappaB", "start": 129, "end": 138}]}}, "schema": []}
{"input": "Thus, patients with metastatic melanoma are not tolerant to gp100 Ag based on the detection of CD8 + T cells specific for multiple HLA-A * 0201-restricted, gp100-derived epitopes.", "output": {"entities": {"gene": [{"text": "gp100 Ag", "start": 60, "end": 68}, {"text": "CD8 +", "start": 95, "end": 100}, {"text": "HLA-A * 0201", "start": 131, "end": 143}, {"text": "gp100", "start": 156, "end": 161}]}}, "schema": []}
{"input": "Following the observation that non-organ-specific antibodies are related with pregnancy loss and preeclampsia, the role of organ-specific antibodies is currently being extensively investigated.", "output": {"entities": {}}, "schema": []}
{"input": "The Mif1 5' flanking region contains a functional ER stress-responsive element which is sufficient for induction by tunicamycin.", "output": {"entities": {"gene": [{"text": "Mif1 5' flanking region", "start": 4, "end": 27}]}}, "schema": []}
{"input": "Rigid point feature registration using mutual information.", "output": {"entities": {}}, "schema": []}
{"input": "Methysergide is a serotonin antagonist and has been demonstrated to reduce wound blood flow and edema formation.", "output": {"entities": {}}, "schema": []}
{"input": "Serum leptin concentrations in women during gonadotropin stimulation cycles.", "output": {"entities": {"gene": [{"text": "leptin", "start": 6, "end": 12}, {"text": "gonadotropin", "start": 44, "end": 56}]}}, "schema": []}
{"input": "Valuing families: social work practice with families from a strengths perspective.", "output": {"entities": {}}, "schema": []}
{"input": "PURPOSE: A two-generation consanguineous Pakistani family with autosomal recessive Leber congenital amaurosis (LCA, MIM 204, 000) and keratoconus was identified.", "output": {"entities": {}}, "schema": []}
{"input": "Ste18p was targeted to the plasma membrane even in the absence of prenylation or thioacylation.", "output": {"entities": {"gene": [{"text": "Ste18p", "start": 0, "end": 6}]}}, "schema": []}
{"input": "Here, we show that IRF-1 is degraded via the ubiquitin-proteasome pathway.", "output": {"entities": {"gene": [{"text": "IRF-1", "start": 19, "end": 24}, {"text": "ubiquitin", "start": 45, "end": 54}]}}, "schema": []}
{"input": "Here we show that IIIa pre-mRNA splicing is activated more than 200-fold in nuclear extracts prepared from late adenovirus-infected cells (Ad-NE) compared to uninfected HeLa cell nuclear extracts (HeLa-NE).", "output": {"entities": {}}, "schema": []}
{"input": "Inactivation of Ulp2 also suppresses several ulp1 (ts) defects, and the double mutant accumulates far fewer Smt3-protein conjugates than either single mutant.", "output": {"entities": {"gene": [{"text": "Ulp2", "start": 16, "end": 20}, {"text": "ulp1 (ts)", "start": 45, "end": 54}, {"text": "Smt3-protein", "start": 108, "end": 120}]}}, "schema": []}
{"input": "Cyclin A expression is repressed in quiescent cells by E2F acting in conjunction with its pocket protein partners Rb, p107, and p130; however, v-Jun overrides this control, causing phosphorylated Rb and proliferation-specific E2F-p107 complexes to persist after mitogen withdrawal.", "output": {"entities": {"gene": [{"text": "Cyclin A", "start": 0, "end": 8}, {"text": "E2F", "start": 55, "end": 58}, {"text": "Rb", "start": 114, "end": 116}, {"text": "p107", "start": 118, "end": 122}, {"text": "p130", "start": 128, "end": 132}, {"text": "v-Jun", "start": 143, "end": 148}, {"text": "Rb", "start": 196, "end": 198}, {"text": "E2F", "start": 226, "end": 229}, {"text": "p107", "start": 230, "end": 234}]}}, "schema": []}
{"input": "D-cyclin-cdk activity is required for Rb phosphorylation in v-Jun-transformed cells, since ectopic expression of the cdk4-and cdk6-specific inhibitor p16 (INK4A) inhibits both DNA synthesis and cell proliferation.", "output": {"entities": {"gene": [{"text": "D-cyclin", "start": 0, "end": 8}, {"text": "cdk", "start": 9, "end": 12}, {"text": "Rb", "start": 38, "end": 40}, {"text": "v-Jun", "start": 60, "end": 65}, {"text": "cdk4", "start": 117, "end": 121}, {"text": "cdk6", "start": 126, "end": 130}, {"text": "p16", "start": 150, "end": 153}, {"text": "INK4A", "start": 155, "end": 160}]}}, "schema": []}
{"input": "CONCLUSION: A valve-like mechanism formed by the capsulorhexis rim partially adhered to the IOL optic can occur postoperatively.", "output": {"entities": {}}, "schema": []}
{"input": "The protein first identified by the monoclonal antibody Q18 is encoded by a gene located in 57A on polytene chromosomes and has been consequently named Hrb57A.", "output": {"entities": {"gene": [{"text": "monoclonal antibody Q18", "start": 36, "end": 59}, {"text": "Hrb57A", "start": 152, "end": 158}]}}, "schema": []}
{"input": "3' RNA boundary experiments indicate that the 5' structure reduces the number of (G/U) AG repeats required for stable TRAP-trp leader RNA association.", "output": {"entities": {"gene": [{"text": "TRAP", "start": 118, "end": 122}, {"text": "trp", "start": 123, "end": 126}]}}, "schema": []}
{"input": "Gene silencing associated with repeated DNA sequences has been reported for many eukaryotes, including plants.", "output": {"entities": {}}, "schema": []}
{"input": "Animals received a dose of dexamethasone (10 mg/kg i. p.) prior to the protein-free surfactant preparation Exosurf (pure phospholipids containing surfactant, Wellcome GmbH, Burgwedel, Germany) and a rSP-C based surfactant, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "BACKGROUND: The aim of this study was to determine the response rates and toxicity of two regimens containing granulocyte-macrophage-colony stimulating factor (GM-CSF) in combination with interleukin-2 (IL-2) in the treatment of patients with metastatic renal cell carcinoma.", "output": {"entities": {"gene": [{"text": "granulocyte-macrophage-colony stimulating factor", "start": 110, "end": 158}, {"text": "GM-CSF", "start": 160, "end": 166}, {"text": "interleukin-2", "start": 188, "end": 201}, {"text": "IL-2", "start": 203, "end": 207}]}}, "schema": []}
{"input": "We show, by injection of synthetic mRNAs, that the cis-acting sequences responsible for repression of cyclin B1 mRNA reside within its 3' UTR.", "output": {"entities": {"gene": [{"text": "cyclin B1 mRNA", "start": 102, "end": 116}]}}, "schema": []}
{"input": "These data indicate that expansion of the dodecamer repeat located in the proximal promoter of CSTB severely disrupts the function of the promoter and thereby reduces transcription of CSTB.", "output": {"entities": {"gene": [{"text": "CSTB", "start": 95, "end": 99}, {"text": "CSTB", "start": 184, "end": 188}]}}, "schema": []}
{"input": "Thus, while the genomic organization of mHuA is similar to the neural-restricted members of the Elav family, the promoter element differs substantially both by sequence analysis and transcriptional activity in non-neural cell types.", "output": {"entities": {"gene": [{"text": "mHuA", "start": 40, "end": 44}, {"text": "Elav family", "start": 96, "end": 107}]}}, "schema": []}
{"input": "Analysis of the 5' end of the mouse Elavl1 (mHuA) gene reveals a transcriptional regulatory element and evidence for conserved genomic organization. mHuA (Elavl1) belongs to a highly conserved family of genes encoding RNA-binding proteins and has been linked to cell growth and proliferation through its regulation of mRNA stability.", "output": {"entities": {"gene": [{"text": "mouse Elavl1", "start": 30, "end": 42}, {"text": "mHuA", "start": 44, "end": 48}, {"text": "mHuA", "start": 149, "end": 153}, {"text": "Elavl1", "start": 155, "end": 161}]}}, "schema": []}
{"input": "Fgd3 and FGD1 share a high degree of sequence identity that spans > 560 contiguous amino acid residues.", "output": {"entities": {"gene": [{"text": "Fgd3", "start": 0, "end": 4}, {"text": "FGD1", "start": 9, "end": 13}]}}, "schema": []}
{"input": "Molecular cloning of mouse thioredoxin reductases.", "output": {"entities": {"gene": [{"text": "mouse thioredoxin reductases", "start": 21, "end": 49}]}}, "schema": []}
{"input": "The HPLC method involves an octadecylsilane column at 55 degrees C, a mixture of water-acetonitrile-orthophosphoric acid (779: 220: 1, v/v) as mobile phase and detection at 226 nm.", "output": {"entities": {}}, "schema": []}
{"input": "CYC2 encodes a 24-kDa protein that has sequence identity to the Neurospora crassa PREG1 and the S. cerevisiae PHO80 cyclin.", "output": {"entities": {"gene": [{"text": "CYC2", "start": 0, "end": 4}, {"text": "Neurospora crassa PREG1", "start": 64, "end": 87}, {"text": "S. cerevisiae PHO80 cyclin", "start": 96, "end": 122}]}}, "schema": []}
{"input": "To determine if CYC2 is found in a complex with previously identified trypanosome cdc2-related kinases (CRKs), the CYC2 gene was fused to the TY epitope tag, integrated into the trypanosome genome, and expressed under inducible control.", "output": {"entities": {"gene": [{"text": "CYC2", "start": 16, "end": 20}, {"text": "trypanosome cdc2-related kinases", "start": 70, "end": 102}, {"text": "CRKs", "start": 104, "end": 108}, {"text": "CYC2 gene", "start": 115, "end": 124}, {"text": "TY epitope", "start": 142, "end": 152}]}}, "schema": []}
{"input": "These findings indicate the involvement of Sp1 and an Inr in non-cell-specific regulation and a Kruppel-like transcription factor and Sp1 in the cell-specific regulation of the LTC (4) S gene.", "output": {"entities": {"gene": [{"text": "Sp1", "start": 43, "end": 46}, {"text": "Kruppel-like transcription factor", "start": 96, "end": 129}, {"text": "Sp1", "start": 134, "end": 137}, {"text": "LTC (4) S gene", "start": 177, "end": 191}]}}, "schema": []}
{"input": "Here we review progress to date in this area.", "output": {"entities": {}}, "schema": []}
{"input": "Additionally, the mouse promoter contains 22 copies of a CT dinucleotide repeat sequence located approximately 155 bp 5' to exon 1.", "output": {"entities": {}}, "schema": []}
{"input": "The newly defined region contains an intron that may be alternatively spliced and seven polyadenylation signal sequences.", "output": {"entities": {}}, "schema": []}
{"input": "Depleted and enriched U3O8 standard reference materials were used to calibrate the system.", "output": {"entities": {}}, "schema": []}
{"input": "Therefore, the positive cAMP control of the hypoxic SRP1 and HEM13 genes was uncoupled from the HOG pathway.", "output": {"entities": {"gene": [{"text": "SRP1", "start": 52, "end": 56}, {"text": "HEM13 genes", "start": 61, "end": 72}, {"text": "HOG", "start": 96, "end": 99}]}}, "schema": []}
{"input": "This paper reviews the middleware-based approach adopted by CEN ENV 12967-1 and the specialisation necessary for the healthcare record based on CEN ENV 12265' Electronic Healthcare Record Architecture'.", "output": {"entities": {}}, "schema": []}
{"input": "Sequence analyses of sos2 mutant alleles reveal that both the N-terminal catalytic domain and the C-terminal regulatory domain of SOS2 are functionally essential.", "output": {"entities": {"gene": [{"text": "sos2 mutant alleles", "start": 21, "end": 40}, {"text": "SOS2", "start": 130, "end": 134}]}}, "schema": []}
{"input": "A mutation which abrogates the binding of these factors reduces Wp reporter activity specifically in B cell lines, whereas a mutation which converts the site to a consensus CREB-binding sequence maintains wild-type promoter function.", "output": {"entities": {"gene": [{"text": "Wp reporter", "start": 64, "end": 75}, {"text": "CREB-binding sequence", "start": 173, "end": 194}]}}, "schema": []}
{"input": "Therefore the binding sites for liver-enriched factors, present in the hamster CYP7A1 proximal promoter in close vicinity and conserved between species, constitute a regulatory unit important for basal hepatic expression and tissue restriction of the action of hormones such as insulin.", "output": {"entities": {"gene": [{"text": "hamster CYP7A1 proximal promoter", "start": 71, "end": 103}, {"text": "insulin", "start": 278, "end": 285}]}}, "schema": []}
{"input": "The kinase activity of PfPK6 is sensitive to CDK inhibitors such as olomoucine and roscovitine.", "output": {"entities": {"gene": [{"text": "PfPK6", "start": 23, "end": 28}, {"text": "CDK", "start": 45, "end": 48}]}}, "schema": []}
{"input": "Although MAP (mitogen-activated protein) kinases are implicated in cell proliferation and differentiation in many cell types, the role of MAP kinases in cardiac hypertrophy remains unclear.", "output": {"entities": {"gene": [{"text": "MAP (mitogen-activated protein) kinases", "start": 9, "end": 48}, {"text": "MAP kinases", "start": 138, "end": 149}]}}, "schema": []}
{"input": "Transfection with a CSF-1R expression plasmid permitted CSF-1-dependent activation of the signalling pathway targeting an Ets/AP1 (activator protein 1) element in the uPA promoter that has been shown previously to be a target of oncogenic ras and protein kinase C pathways.", "output": {"entities": {"gene": [{"text": "CSF-1R", "start": 20, "end": 26}, {"text": "CSF-1", "start": 56, "end": 61}, {"text": "Ets", "start": 122, "end": 125}, {"text": "AP1", "start": 126, "end": 129}, {"text": "activator protein 1", "start": 131, "end": 150}, {"text": "uPA promoter", "start": 167, "end": 179}, {"text": "oncogenic ras", "start": 229, "end": 242}]}}, "schema": []}
{"input": "Regulation of urokinase plasminogen activator gene transcription in the RAW264 murine macrophage cell line by macrophage colony-stimulating factor (CSF-1) is dependent upon the level of cell-surface receptor.", "output": {"entities": {"gene": [{"text": "urokinase plasminogen activator gene", "start": 14, "end": 50}, {"text": "macrophage colony-stimulating factor", "start": 110, "end": 146}, {"text": "CSF-1", "start": 148, "end": 153}]}}, "schema": []}
{"input": "Molecule (s) secreted by neuronal cultures contribute to this induction of GLT-1, but little is known about the signaling pathways mediating this regulation.", "output": {"entities": {"gene": [{"text": "GLT-1", "start": 75, "end": 80}]}}, "schema": []}
{"input": "Coactivation of endogenous or exogenous G (q)-coupled receptors with the delta-opioid receptor produced strong stimulations of PLCbeta and such responses could be partially blocked by pertussis toxin.", "output": {"entities": {"gene": [{"text": "G (q)-coupled receptors", "start": 40, "end": 63}, {"text": "delta-opioid receptor", "start": 73, "end": 94}, {"text": "PLCbeta", "start": 127, "end": 134}, {"text": "pertussis toxin", "start": 184, "end": 199}]}}, "schema": []}
{"input": "Patients enrolled in the Integrilin to Minimize Platelet Aggregation and Coronary Thrombosis-II (IMPACT-II) trial were analyzed.", "output": {"entities": {}}, "schema": []}
{"input": "The Wnt signaling pathway functions reiteratively during animal development to control cell fate decisions.", "output": {"entities": {"gene": [{"text": "Wnt", "start": 4, "end": 7}]}}, "schema": []}
{"input": "This mutation no longer repressed the HPV-11 upstream regulatory region-controlled reporter expression.", "output": {"entities": {}}, "schema": []}
{"input": "In the icosahaedral MVMi capsid, this sequence forms the carboxy end of the amphipathic beta-strand I (betaI), and all its basic residues are contiguously positioned at the face that in the unassembled subunit would be exposed to solvent.", "output": {"entities": {}}, "schema": []}
{"input": "The two contiguous IGF2 (human insulin-like growth factor II) and H19 genes are reciprocally imprinted in both human and mouse.", "output": {"entities": {"gene": [{"text": "IGF2", "start": 19, "end": 23}, {"text": "human insulin-like growth factor II", "start": 25, "end": 60}, {"text": "H19 genes", "start": 66, "end": 75}]}}, "schema": []}
{"input": "The asymmetric methylation was associated with tissue-specific disruption of H19 genomic imprinting in fetal brain.", "output": {"entities": {"gene": [{"text": "H19", "start": 77, "end": 80}]}}, "schema": []}
{"input": "Early treatment mechanics of the Class II division 2 malocclusion.", "output": {"entities": {}}, "schema": []}
{"input": "The consensus highlights the importance of residues other than the eight motifs that are often associated with DEAD-box RNA helicases, as well as de-emphasising the importance of the \" A \" residue within the \" DEAD \" motif.", "output": {"entities": {"gene": [{"text": "DEAD-box RNA helicases", "start": 111, "end": 133}]}}, "schema": []}
{"input": "In transient assays, using rice suspension-cultured cells transformed by particle bombardment, we showed previously that Oshox1 can transcriptionally repress the activity of reporter gene constructs with upstream HD-Zip binding sites.", "output": {"entities": {"gene": [{"text": "Oshox1", "start": 121, "end": 127}, {"text": "HD-Zip", "start": 213, "end": 219}]}}, "schema": []}
{"input": "Results of two-hybrid assays and electrophoretic mobility shift assays strongly suggest that all HD-Zip proteins of families I and II can form homodimers and also heterodimers with all HD-Zip proteins of the same family.", "output": {"entities": {"gene": [{"text": "HD-Zip proteins", "start": 97, "end": 112}, {"text": "HD-Zip proteins", "start": 185, "end": 200}]}}, "schema": []}
{"input": "Among mammalian HSFs, HSF1 has been shown to be important for regulation of the heat-induced stress gene expression, whereas the function of HSF2 in stress response is unclear.", "output": {"entities": {"gene": [{"text": "mammalian HSFs", "start": 6, "end": 20}, {"text": "HSF1", "start": 22, "end": 26}, {"text": "HSF2", "start": 141, "end": 145}]}}, "schema": []}
{"input": "Importantly, concomitant expression of constitutive activated Raf and V12N38 Ras results in almost complete loss of TTF-1 activity.", "output": {"entities": {"gene": [{"text": "Raf", "start": 62, "end": 65}, {"text": "V12N38 Ras", "start": 70, "end": 80}, {"text": "TTF-1", "start": 116, "end": 121}]}}, "schema": []}
{"input": "They share many downstream targets, including remodeling of the actin cytoskeleton, activation of p70 (S6) kinase and c-jun N-terminal kinase (JNK), and regulation of transcription and cell proliferation.", "output": {"entities": {"gene": [{"text": "actin", "start": 64, "end": 69}, {"text": "p70 (S6) kinase", "start": 98, "end": 113}, {"text": "c-jun N-terminal kinase", "start": 118, "end": 141}, {"text": "JNK", "start": 143, "end": 146}]}}, "schema": []}
{"input": "Expression of activated Cdc42 results in the translocation of PKClambda from the nucleus into the cytosol, and Cdc42 and PKClambda colocalize at the plasma membrane and in the cytoplasm.", "output": {"entities": {"gene": [{"text": "Cdc42", "start": 24, "end": 29}, {"text": "PKClambda", "start": 62, "end": 71}, {"text": "Cdc42", "start": 111, "end": 116}, {"text": "PKClambda", "start": 121, "end": 130}]}}, "schema": []}
{"input": "Copyright 2000 Academic Press.", "output": {"entities": {}}, "schema": []}
{"input": "Southern blotting and single strand conformation polymorphism analyses did not show tumor-specific alterations of this gene in gliomas and RT-PCR studies showed expression in glioma cell lines, suggesting that ANOVA is not the chromosome 19q glioma tumor suppressor gene.", "output": {"entities": {"gene": [{"text": "ANOVA", "start": 210, "end": 215}]}}, "schema": []}
{"input": "Enzyme I of the phosphoenolpyruvate: sugar phosphotransferase system.", "output": {"entities": {"gene": [{"text": "Enzyme I", "start": 0, "end": 8}, {"text": "phosphoenolpyruvate: sugar phosphotransferase", "start": 16, "end": 61}]}}, "schema": []}
{"input": "Based on these data, we conclude that transcription of prgX is initiated from the Qa promoter in prgQ, and PrgX autoregulates its transcription either by mediating transcriptional readthrough or increasing mRNA stability.", "output": {"entities": {"gene": [{"text": "prgX", "start": 55, "end": 59}, {"text": "Qa promoter", "start": 82, "end": 93}, {"text": "prgQ", "start": 97, "end": 101}, {"text": "PrgX", "start": 107, "end": 111}]}}, "schema": []}
{"input": "It was established that intrathecal or intraperitoneal PTFL, elevated the nociceptive threshold for mechanical stimuli in the formalin test in rats.", "output": {"entities": {}}, "schema": []}
{"input": "Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV.", "output": {"entities": {}}, "schema": []}
{"input": "Family environment was an important influence on interpersonal relationships, substance use, and social support.", "output": {"entities": {}}, "schema": []}
{"input": "By electrophoresis mobility shift assays using probes corresponding to different segments of the putative human c-myb intron 1 transcription pause region and nuclear extracts from myeloid leukemia HL 60 and fibroblast WI 38 cells, we detected a HL-60-specific DNA-protein complex with a 123-bp fragment containing binding sites for the interferon regulatory factors (IRFs) nuclear proteins.", "output": {"entities": {"gene": [{"text": "human c-myb intron 1 transcription pause region", "start": 106, "end": 153}, {"text": "interferon regulatory factors", "start": 336, "end": 365}, {"text": "IRFs", "start": 367, "end": 371}]}}, "schema": []}
{"input": "STUDY DESIGN: Fine needle aspiration cytologic smears from 21 cases of invasive lobular carcinoma (ILC) of breast were subjected to detailed cytomorphologic analysis.", "output": {"entities": {}}, "schema": []}
{"input": "Electrophile Response Elements (EpREs), located in 5'-flanking sequences of both the GCSh and GCSl subunit genes, are hypothesized to at least partially mediate gene induction following xenobiotic exposure.", "output": {"entities": {"gene": [{"text": "GCSh", "start": 85, "end": 89}, {"text": "GCSl subunit genes", "start": 94, "end": 112}]}}, "schema": []}
{"input": "A new technique to create an artificial stenosis in the native LAD using a hemoclip.", "output": {"entities": {}}, "schema": []}
{"input": "Dll3 is mutated in the X-ray-induced mouse mutant pudgy (pu), causing a variety of vertebrocostal defects similar to SD phenotypes.", "output": {"entities": {"gene": [{"text": "Dll3", "start": 0, "end": 4}, {"text": "mouse mutant pudgy", "start": 37, "end": 55}, {"text": "pu", "start": 57, "end": 59}]}}, "schema": []}
{"input": "TbRAB31 behaviour was also studied during the cell cycle; TbRAB31 always localised to a discrete structure that duplicated very early in mitosis and relocated to daughter cells in a coordinate manner with the basal body and kinetoplast, suggesting the involvement of microtubules.", "output": {"entities": {"gene": [{"text": "TbRAB31", "start": 0, "end": 7}, {"text": "TbRAB31", "start": 58, "end": 65}]}}, "schema": []}
{"input": "Invertases are responsible for the breakdown of sucrose to fructose and glucose.", "output": {"entities": {"gene": [{"text": "Invertases", "start": 0, "end": 10}]}}, "schema": []}
{"input": "To investigate the molecular mechanisms of this Tax-mediated inhibition, we analyzed its effect on the transcriptional activity of the myogenic MyoD protein, which was used as a paradigm of bHLH factors.", "output": {"entities": {"gene": [{"text": "Tax", "start": 48, "end": 51}, {"text": "MyoD protein", "start": 144, "end": 156}, {"text": "bHLH factors", "start": 190, "end": 202}]}}, "schema": []}
{"input": "The human T cell leukemia/lymphotropic virus type 1 Tax protein represses MyoD-dependent transcription by inhibiting MyoD-binding to the KIX domain of p300.", "output": {"entities": {"gene": [{"text": "human T cell leukemia/lymphotropic virus type 1 Tax protein", "start": 4, "end": 63}, {"text": "MyoD", "start": 74, "end": 78}, {"text": "MyoD", "start": 117, "end": 121}, {"text": "KIX domain", "start": 137, "end": 147}, {"text": "p300", "start": 151, "end": 155}]}}, "schema": []}
{"input": "Phosphorylation and spindle pole body localization of the Cdc15p mitotic regulatory protein kinase in budding yeast.", "output": {"entities": {"gene": [{"text": "Cdc15p mitotic regulatory protein kinase in budding yeast", "start": 58, "end": 115}]}}, "schema": []}
{"input": "Thus, both the hyperplasia and thrombotic complications which often follow stenting might be minimized by employing gold stents, which have a greater capacity than steel in supporting a functional neo-endothelium.", "output": {"entities": {}}, "schema": []}
{"input": "The cell cycle and transcriptional defects caused by taf17 (slm7-1) are consistent with the role of TAF (II) s as modulators of transcriptional activation and may reflect a role for TAF17 in regulating activation by SBF and MBF.", "output": {"entities": {"gene": [{"text": "taf17", "start": 53, "end": 58}, {"text": "slm7-1", "start": 60, "end": 66}, {"text": "TAF (II) s", "start": 100, "end": 110}, {"text": "TAF17", "start": 182, "end": 187}, {"text": "SBF", "start": 216, "end": 219}, {"text": "MBF", "start": 224, "end": 227}]}}, "schema": []}
{"input": "Proteolysis of Mbp1 and Swi4 DNA-protein complexes has revealed the extent of these sequences, and C-terminally extended molecules with substantially enhanced DNA binding activity compared to the core domains alone have been produced.", "output": {"entities": {"gene": [{"text": "Mbp1", "start": 15, "end": 19}, {"text": "Swi4 DNA-protein complexes", "start": 24, "end": 50}]}}, "schema": []}
{"input": "These results indicate that residue 266 serves as a \" protein sensor \" of altered minor groove interactions and identifies which base pair interactions are altered by these lesions.", "output": {"entities": {}}, "schema": []}
{"input": "The recombinant enzymes exist as monomers.", "output": {"entities": {}}, "schema": []}
{"input": "A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux.", "output": {"entities": {"gene": [{"text": "B lymphocyte antigen receptor", "start": 28, "end": 57}]}}, "schema": []}
{"input": "We now describe a second RIM protein, called RIM2, that is highly homologous to RIM1 and also expressed primarily in brain.", "output": {"entities": {"gene": [{"text": "RIM protein", "start": 25, "end": 36}, {"text": "RIM2", "start": 45, "end": 49}, {"text": "RIM1", "start": 80, "end": 84}]}}, "schema": []}
{"input": "Inhibitor-1 (I-1) and inhibitor-2 (I-2) selectively inhibit type 1 protein serine/threonine phosphatases (PP1).", "output": {"entities": {"gene": [{"text": "Inhibitor-1", "start": 0, "end": 11}, {"text": "I-1", "start": 13, "end": 16}, {"text": "inhibitor-2", "start": 22, "end": 33}, {"text": "I-2", "start": 35, "end": 38}, {"text": "type 1 protein serine/threonine phosphatases", "start": 60, "end": 104}, {"text": "PP1", "start": 106, "end": 109}]}}, "schema": []}
{"input": "The substrates for glycan synthesis in the lumen of the Golgi are nucleotide sugars that must be transported from the cytosol by specific membrane-bound transporters.", "output": {"entities": {}}, "schema": []}
{"input": "Synaptic targeting of the postsynaptic density protein PSD-95 mediated by a tyrosine-based trafficking signal.", "output": {"entities": {"gene": [{"text": "postsynaptic density protein PSD-95", "start": 26, "end": 61}]}}, "schema": []}
{"input": "(1998) J.", "output": {"entities": {}}, "schema": []}
{"input": "Both normal and transforming PCPH proteins have guanosine diphosphatase activity but only the oncoprotein cooperates with Ras in activating extracellular signal-regulated kinase ERK1.", "output": {"entities": {"gene": [{"text": "PCPH proteins", "start": 29, "end": 42}, {"text": "guanosine diphosphatase", "start": 48, "end": 71}, {"text": "Ras", "start": 122, "end": 125}, {"text": "extracellular signal-regulated kinase ERK1", "start": 140, "end": 182}]}}, "schema": []}
{"input": "These results indicate that virulence-associated genes and their overall chromosomal arrangement are relatively well conserved between B. henselae and other gram-negative bacteria such as A. tumefaciens.", "output": {"entities": {}}, "schema": []}
{"input": "An important mechanism by which the tumor suppressor p53 maintains genomic stability is to induce cell cycle arrest through activation of the cyclin-dependent kinase inhibitor p21 (WAF1/Cip1) gene.", "output": {"entities": {"gene": [{"text": "p53", "start": 53, "end": 56}, {"text": "cyclin-dependent kinase", "start": 142, "end": 165}, {"text": "p21", "start": 176, "end": 179}, {"text": "WAF1", "start": 181, "end": 185}, {"text": "Cip1", "start": 186, "end": 190}]}}, "schema": []}
{"input": "Paxillin acts as an adaptor molecule in integrin signaling.", "output": {"entities": {"gene": [{"text": "Paxillin", "start": 0, "end": 8}, {"text": "integrin", "start": 40, "end": 48}]}}, "schema": []}
{"input": "Thus, growth factor activation of ER can mediate transactivation vs ER/Sp1 binding to GC-rich sites and represents a novel pathway for ligand-independent ER action.", "output": {"entities": {"gene": [{"text": "ER", "start": 34, "end": 36}, {"text": "ER", "start": 68, "end": 70}, {"text": "Sp1", "start": 71, "end": 74}, {"text": "ER", "start": 154, "end": 156}]}}, "schema": []}
{"input": "Furthermore, analysis of deletion promoter-reporter constructs found that the basal activity of P2 resided in the proximal region of P2.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: Auditory thresholds collected during audiometric tests increased gradually in proportion with age, especially in the hypertensive group (p < 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "In addition, the transcription of c-IAP2 promoter was strongly up-regulated when CD40 or Epstein-Barr virus latent membrane protein 1 was overexpressed.", "output": {"entities": {"gene": [{"text": "c-IAP2 promoter", "start": 34, "end": 49}, {"text": "CD40", "start": 81, "end": 85}, {"text": "Epstein-Barr virus latent membrane protein 1", "start": 89, "end": 133}]}}, "schema": []}
{"input": "A variety of professional and self-applied fluoride products are available and new fluoride delivery systems have recently entered the market.", "output": {"entities": {}}, "schema": []}
{"input": "These studies identify several of the signal-transduction events involved in the apoptosis of malignant B cells that transpire following ligation of CD20 by anti-CD20 antibodies in the presence of Fc-receptor-expressing cells or secondary goat anti-(mouse Ig) antibodies and which may contribute to the tumor regressions observed in mouse models and clinical trials.", "output": {"entities": {"gene": [{"text": "CD20", "start": 149, "end": 153}, {"text": "anti-CD20 antibodies", "start": 157, "end": 177}, {"text": "Fc-receptor", "start": 197, "end": 208}, {"text": "anti-(mouse Ig) antibodies", "start": 244, "end": 270}]}}, "schema": []}
{"input": "Phenazone potentiates the local anaesthetic effect of lidocaine in mice.", "output": {"entities": {}}, "schema": []}
{"input": "The solubility of all the mutated proteins was remarkably reduced.", "output": {"entities": {}}, "schema": []}
{"input": "Recently, identical RBE sequences have been identified at other locations in the human genome.", "output": {"entities": {"gene": [{"text": "RBE sequences", "start": 20, "end": 33}]}}, "schema": []}
{"input": "EM analysis demonstrated that only one Rep-DNA complex was formed on ch-19 target DNA.", "output": {"entities": {"gene": [{"text": "Rep-DNA complex", "start": 39, "end": 54}]}}, "schema": []}
{"input": "The protein was associated with purified vaccinia virus particles and with membranes of immature and mature virions that were visualized by electron microscopy of infected cells.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSION: More than 50% of patients with perennial rhinitis and CRS do not improve after surgery, a response that may be predicted by more cells expressing IL-5 mRNA in the ethmoid sinuses.", "output": {"entities": {"gene": [{"text": "IL-5 mRNA", "start": 158, "end": 167}]}}, "schema": []}
{"input": "On the basis of size, the CRS sequence to which it binds, and its tentative identification as a zinc finger protein, Adx factor has been identified as a Kruppel-like zinc finger protein (a mouse ZBP-89 homologue).", "output": {"entities": {"gene": [{"text": "zinc finger protein", "start": 96, "end": 115}, {"text": "Adx factor", "start": 117, "end": 127}, {"text": "Kruppel-like zinc finger protein", "start": 153, "end": 185}, {"text": "mouse ZBP-89 homologue", "start": 189, "end": 211}]}}, "schema": []}
{"input": "METHODS: The most distal muscle fibres from the deep and superficial finger flexors were measured relative to the pisiform bone in 18 cadaveric specimens.", "output": {"entities": {}}, "schema": []}
{"input": "Here we report on the isolation of ICK2, and show that it interacts with Cdc2aAt, but not with a second CDK from Arabidopsis, Cdc2bAt.", "output": {"entities": {"gene": [{"text": "ICK2", "start": 35, "end": 39}, {"text": "Cdc2aAt", "start": 73, "end": 80}, {"text": "CDK from Arabidopsis", "start": 104, "end": 124}, {"text": "Cdc2bAt", "start": 126, "end": 133}]}}, "schema": []}
{"input": "Systemic impact of risk-sharing arrangements.", "output": {"entities": {}}, "schema": []}
{"input": "METHODS: We determined an odds ratio (OR), as a measure of the relative risk of being exposed to a potential interaction, comparing the use of the H2-receptor antagonist, cimetidine, with that of the noninteracting agents ranitidine, famotidine and nizatidine in users and nonusers of warfarin, phenytoin and theophylline.", "output": {"entities": {"gene": [{"text": "H2-receptor", "start": 147, "end": 158}]}}, "schema": []}
{"input": "The prevalence of malnutrition was 30% in the 47 patients without CVD and was significantly higher (70%, P < 0. 001) in the 70 patients with CVD, who also had lower tHcy, SAlb, plasma IGF-1, serum creatinine (SCr), and blood hemoglobin.", "output": {"entities": {"gene": [{"text": "plasma IGF-1", "start": 177, "end": 189}, {"text": "blood hemoglobin", "start": 219, "end": 235}]}}, "schema": []}
{"input": "Our data suggest that, at least at high temperature, a critical minimal level of Ypt protein prenylation is required for maintaining vesicle polarization.", "output": {"entities": {"gene": [{"text": "Ypt protein", "start": 81, "end": 92}]}}, "schema": []}
{"input": "The second functional pair of CreA sites is located between the two transcription initiation sites.", "output": {"entities": {"gene": [{"text": "CreA sites", "start": 30, "end": 40}]}}, "schema": []}
{"input": "A distinct staining pattern for the N-utrophin was not detectable, although it was expected to localise at the actin stress fibers.", "output": {"entities": {"gene": [{"text": "N-utrophin", "start": 36, "end": 46}, {"text": "actin", "start": 111, "end": 116}]}}, "schema": []}
{"input": "The' Newcastle' model, which is based on Hotelling' s T2 statistic, proved to be more sensitive and diagnosed a systematic displacement for three prostate patients.", "output": {"entities": {}}, "schema": []}
{"input": "The MMA, DMA, and TMA methyltransferases are not homologs; however, like the MMA methyltransferase gene, the genes encoding the DMA and TMA methyltransferases each contain a single in-frame amber codon.", "output": {"entities": {"gene": [{"text": "MMA, DMA, and TMA methyltransferases", "start": 4, "end": 40}, {"text": "MMA methyltransferase gene", "start": 77, "end": 103}, {"text": "DMA and TMA methyltransferases", "start": 128, "end": 158}]}}, "schema": []}
{"input": "After phosphorylation, STAT proteins are transported into the nucleus and exhibit transcriptional activity.", "output": {"entities": {"gene": [{"text": "STAT proteins", "start": 23, "end": 36}]}}, "schema": []}
{"input": "Overexpression of mcl-1 is sufficient to protect against apoptosis, while transfection of a mcl-1 antisense plasmid causes cell death.", "output": {"entities": {"gene": [{"text": "mcl-1", "start": 18, "end": 23}, {"text": "mcl-1", "start": 92, "end": 97}]}}, "schema": []}
{"input": "Thus, although multiple senescence pathways are activated in response to a ras oncogene, inactivation of TGFbeta1 secretion or response is sufficient to block the senescence program.", "output": {"entities": {"gene": [{"text": "ras oncogene", "start": 75, "end": 87}, {"text": "TGFbeta1", "start": 105, "end": 113}]}}, "schema": []}
{"input": "In this study, the abilities of constitutive and conditional forms of the three Raf kinases to abrogate the cytokine dependency of FDC-P1 cells were examined.", "output": {"entities": {"gene": [{"text": "Raf kinases", "start": 80, "end": 91}]}}, "schema": []}
{"input": "Application of the method to a representative set of 50 known genes from Arabidopsis thaliana showed significant improvement in prediction accuracy compared to previous spliced alignment methods.", "output": {"entities": {}}, "schema": []}
{"input": "The complete cDNA sequence of human betaV spectrin is available from GenBank (TM) as accession number.", "output": {"entities": {"gene": [{"text": "human betaV spectrin", "start": 30, "end": 50}]}}, "schema": []}
{"input": "Transactivation of naturally occurring HIV-1 long terminal repeats by the JNK signaling pathway.", "output": {"entities": {"gene": [{"text": "HIV-1 long terminal repeats", "start": 39, "end": 66}, {"text": "JNK", "start": 74, "end": 77}]}}, "schema": []}
{"input": "The mode of resistance to quinupristin/dalfopristin was not evident (sat A-negative by PCR); and these cases illustrate the existence of streptogramin-resistant isolates before the introduction of this antimicrobial class into human clinical practice.", "output": {"entities": {}}, "schema": []}
{"input": "This study was carried out to analyze PRL secretion in metastatic prostate cancer patients both at basal conditions and in response to L-Dopa and metoclopramide, which represents the most classical inhibitory and stimulatory tests for PRL secretion, respectively.", "output": {"entities": {"gene": [{"text": "PRL", "start": 38, "end": 41}, {"text": "PRL", "start": 235, "end": 238}]}}, "schema": []}
{"input": "Integrin adhesion receptors transduce signals that control complex cell functions which require the regulation of gene expression, such as proliferation, differentiation and survival.", "output": {"entities": {"gene": [{"text": "Integrin adhesion receptors", "start": 0, "end": 27}]}}, "schema": []}
{"input": "Recombination, replication, repair: from complexity to harmony.", "output": {"entities": {}}, "schema": []}
{"input": "Hex is expressed in the developing liver coincident with the forkhead/winged helix transcription factor, Hepatocyte Nuclear Factor 3beta (HNF3beta).", "output": {"entities": {"gene": [{"text": "Hex", "start": 0, "end": 3}, {"text": "forkhead", "start": 61, "end": 69}, {"text": "winged helix", "start": 70, "end": 82}, {"text": "Hepatocyte Nuclear Factor 3beta", "start": 105, "end": 136}, {"text": "HNF3beta", "start": 138, "end": 146}]}}, "schema": []}
{"input": "As an extension of our structural characterization of the exon-intron organization of the mouse Pkr gene, we now have isolated and characterized the mouse Pkr promoter region required for IFN-inducible transcription.", "output": {"entities": {"gene": [{"text": "mouse Pkr gene", "start": 90, "end": 104}, {"text": "mouse Pkr promoter region", "start": 149, "end": 174}, {"text": "IFN", "start": 188, "end": 191}]}}, "schema": []}
{"input": "The CRE, 5'-TGACGTCA-3', has been described as the consensus sequence for the cis-element that directs cAMP-regulated gene expression.", "output": {"entities": {}}, "schema": []}
{"input": "Kidney length did not significantly differ between right and left, however, kidney width, cortical thickness and size did (p < 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "The clinical stage was I (T1N0M0), and S2 sleeve segmentectomy with lymph node dissection (R 2 b) was performed.", "output": {"entities": {}}, "schema": []}
{"input": "Benztropine for venlafaxine-induced night sweats.", "output": {"entities": {}}, "schema": []}
{"input": "The physicians in charge of all patients with evidence of acute Q fever (seroconversion and/or presence of IgM) or chronic Q fever (prolonged disease and/or IgG antibody titer to phase I of Coxiella burnetii > or = 800) were asked to complete a questionnaire, which was computerized.", "output": {"entities": {"gene": [{"text": "IgM", "start": 107, "end": 110}, {"text": "IgG antibody", "start": 157, "end": 169}]}}, "schema": []}
{"input": "Copyright 2000 Academic Press.", "output": {"entities": {}}, "schema": []}
{"input": "Viral cell-to-cell movement of PVX CP mutant was complemented in Nicotiana tabacum cv.", "output": {"entities": {"gene": [{"text": "PVX CP mutant", "start": 31, "end": 44}]}}, "schema": []}
{"input": "Induction of CD86 expression by stimulation of U937 cells with IFN-gamma revealed the presence of two functional GAS (gamma-interferon activation site) elements.", "output": {"entities": {"gene": [{"text": "CD86", "start": 13, "end": 17}, {"text": "IFN-gamma", "start": 63, "end": 72}, {"text": "GAS", "start": 113, "end": 116}, {"text": "gamma-interferon activation site", "start": 118, "end": 150}]}}, "schema": []}
{"input": "SNAP-23 plays an important role in the regulation of vesicle trafficking in mammalian cells.", "output": {"entities": {"gene": [{"text": "SNAP-23", "start": 0, "end": 7}]}}, "schema": []}
{"input": "Ab-MLV strains expressing P70/S2 failed to transform NIH 3T3 cells and demonstrated a greatly reduced capacity to mediate signaling events associated with the Ras-dependent mitogen-activated protein (MAP) kinase pathway.", "output": {"entities": {"gene": [{"text": "P70", "start": 26, "end": 29}, {"text": "S2", "start": 30, "end": 32}, {"text": "Ras", "start": 159, "end": 162}, {"text": "mitogen-activated protein (MAP) kinase", "start": 173, "end": 211}]}}, "schema": []}
{"input": "The p53-homolog p73beta also activated the PIG3 promoter, but in contrast to p53, the proline-rich domain of p73beta (residues 81-113) was dispensable to induce the PIG3 promoter.", "output": {"entities": {"gene": [{"text": "p53-homolog p73beta", "start": 4, "end": 23}, {"text": "PIG3 promoter", "start": 43, "end": 56}, {"text": "p53", "start": 77, "end": 80}, {"text": "p73beta (residues 81-113)", "start": 109, "end": 134}, {"text": "PIG3 promoter", "start": 165, "end": 178}]}}, "schema": []}
{"input": "Results from transient assays using these mutants showed that the DE1 received signals from phytochromes A and B, demonstrating that this element is indeed a light-responsive element.", "output": {"entities": {"gene": [{"text": "phytochromes A and B", "start": 92, "end": 112}]}}, "schema": []}
{"input": "Co-immunoprecipitation and DNA affinity chromatography prove that Sp1 heterodimerizes with ZBP-89 when bound to the silencer element to yield a DNA-protein complex whose mobility is indistinguishable from that displayed by HeLa nuclear extract in band shift assays.", "output": {"entities": {"gene": [{"text": "Sp1", "start": 66, "end": 69}, {"text": "ZBP-89", "start": 91, "end": 97}]}}, "schema": []}
{"input": "The ZNF274 gene is mapped distal to marker RP S28 1 in the human chromosome 19qter region, by RH mapping.", "output": {"entities": {"gene": [{"text": "ZNF274 gene", "start": 4, "end": 15}]}}, "schema": []}
{"input": "The C-terminal Cdk2 truncations, however, were non-functional in these strains and thus dependent for activity on the pho85 coding region which remained in the mutant pho85:: HIS3 chromosomal locus.", "output": {"entities": {"gene": [{"text": "C-terminal Cdk2", "start": 4, "end": 19}, {"text": "pho85 coding region", "start": 118, "end": 137}, {"text": "mutant pho85", "start": 160, "end": 172}, {"text": "HIS3 chromosomal locus", "start": 175, "end": 197}]}}, "schema": []}
{"input": "We report here on the molecular nature of an EMS-induced mutant, mn1-89, a leaky semidominant allele of the Miniature1 (Mn1) seed locus that encodes a seed-specific cell wall invertase, INCW2.", "output": {"entities": {"gene": [{"text": "mn1-89", "start": 65, "end": 71}, {"text": "Miniature1", "start": 108, "end": 118}, {"text": "Mn1", "start": 120, "end": 123}, {"text": "seed-specific cell wall invertase", "start": 151, "end": 184}, {"text": "INCW2", "start": 186, "end": 191}]}}, "schema": []}
{"input": "We conclude that, both in atrial myocytes and in Xenopus oocytes, beta-adrenergic stimulation potentiates the ACh-evoked GIRK channels via a pathway that involves PKA-catalyzed phosphorylation downstream from beta (2) AR.", "output": {"entities": {"gene": [{"text": "GIRK channels", "start": 121, "end": 134}, {"text": "PKA", "start": 163, "end": 166}, {"text": "beta (2) AR", "start": 209, "end": 220}]}}, "schema": []}
{"input": "Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins.", "output": {"entities": {"gene": [{"text": "E2F3 product", "start": 26, "end": 38}, {"text": "Rb proteins", "start": 105, "end": 116}]}}, "schema": []}
{"input": "In DNase I footprinting protection analysis, both SFRE and ERE regions were protected by glutathione S-transferase-ERRalpha1 fusion protein.", "output": {"entities": {"gene": [{"text": "DNase I", "start": 3, "end": 10}, {"text": "SFRE", "start": 50, "end": 54}, {"text": "glutathione S-transferase", "start": 89, "end": 114}, {"text": "ERRalpha1", "start": 115, "end": 124}]}}, "schema": []}
{"input": "Overexpressing the coactivator, SRC1a or GRIP1, further enhances ERRalpha1-induced transcriptional activity.", "output": {"entities": {"gene": [{"text": "SRC1a", "start": 32, "end": 37}, {"text": "GRIP1", "start": 41, "end": 46}, {"text": "ERRalpha1", "start": 65, "end": 74}]}}, "schema": []}
{"input": "Estrogen receptor-related receptor alpha 1 interacts with coactivator and constitutively activates the estrogen response elements of the human lactoferrin gene.", "output": {"entities": {"gene": [{"text": "Estrogen receptor-related receptor alpha 1", "start": 0, "end": 42}, {"text": "human lactoferrin gene", "start": 137, "end": 159}]}}, "schema": []}
{"input": "The median levels of particles with 50% cut-off aerodynamic diameters of 10 (PM10) and 2. 5 microm (PM2. 5) were 170 (range 103-613) and 95 (range 61-218) micro x m-3, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana.", "output": {"entities": {}}, "schema": []}
{"input": "Comparison of sequences from-215 to + 1 bp identified consensus binding sites for the homeodomain transcription factor thyroid transcription factor-1 (TTF-1).", "output": {"entities": {"gene": [{"text": "homeodomain transcription factor thyroid transcription factor-1", "start": 86, "end": 149}, {"text": "TTF-1", "start": 151, "end": 156}]}}, "schema": []}
{"input": "Two additional cis-acting sequences, conserved in both the region 1 and 3 promoters, were identified, suggesting a role for these sequences in the coordinate regulation of transcription from these promoters.", "output": {"entities": {}}, "schema": []}
{"input": "Purple photosynthetic bacteria are capable of generating cellular energy from several sources, including photosynthesis, respiration, and H (2) oxidation.", "output": {"entities": {}}, "schema": []}
{"input": "An analysis of synthetic peptides revealed a minimal CTD sequence that is sufficient to bind to the second Rsp5 WW domain (Rsp5 WW2) in vitro and in yeast two-hybrid assays.", "output": {"entities": {"gene": [{"text": "Rsp5 WW domain", "start": 107, "end": 121}, {"text": "Rsp5 WW2", "start": 123, "end": 131}]}}, "schema": []}
{"input": "Furthermore, bone marrow-derived macrophages from LAT-deficient mice displayed reduced phagocytic efficiency in comparison to the macrophages from wild-type mice.", "output": {"entities": {"gene": [{"text": "LAT", "start": 50, "end": 53}]}}, "schema": []}
{"input": "T1-weighted MRI on the 49th postoperative day demonstrated bilateral and symmetrical hyperintense lesions in the globus pallidus.", "output": {"entities": {}}, "schema": []}
{"input": "The method is applied to determine aberration constants of a CM300 FEG/UT microscope with correction of the three-fold astigmatism.", "output": {"entities": {}}, "schema": []}
{"input": "The interaction does not depend on the presence of the correct amino-terminal DNA binding domain or the amino acid sequences between the DNA binding domain and the last ten amino acids.", "output": {"entities": {}}, "schema": []}
{"input": "METHOD: The sample of subjects was drawn from the Suffolk County Mental Health Project, a longitudinal epidemiologic study of first-hospitalized subjects with psychotic disorders; the present study focused on patients with schizophrenic disorders.", "output": {"entities": {}}, "schema": []}
{"input": "Marrow dysplasia is a major characteristic of patients with myelodysplastic syndrome (MDS), along with marrow blastosis, cytopenia and cytogenetic anomalies.", "output": {"entities": {}}, "schema": []}
{"input": "Eight of the non-acceptable inlays/onlays and five of the direct restorations were replaced, while the other ones were repaired with resin composite.", "output": {"entities": {}}, "schema": []}
{"input": "How plants respond to attack by the range of herbivores and pathogens that confront them in the field is the subject of considerable research by both molecular biologists and ecologists.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSION: The probability of cardiopulmonary complications increases significantly when patients develop class 1 HELLP syndrome.", "output": {"entities": {}}, "schema": []}
{"input": "The rate-limiting step for telomerase activity seems to be the expression of the catalytic subunit of the enzyme, encoded by the human telomerase reverse transcriptase (hTERT) gene.", "output": {"entities": {"gene": [{"text": "telomerase", "start": 27, "end": 37}, {"text": "human telomerase reverse transcriptase", "start": 129, "end": 167}, {"text": "hTERT", "start": 169, "end": 174}]}}, "schema": []}
{"input": "In the control group, platelet markers increased 1 h after surgery.", "output": {"entities": {}}, "schema": []}
{"input": "However, the element proximal to the transcription start site is dependent on the SRE-1.", "output": {"entities": {}}, "schema": []}
{"input": "Since proteins containing TPR elements are typically involved in multiple protein-protein interactions, we suggest that the 102kD protein interacts within the tri-snRNP with both the U5 and U4/U6 snRNPs, thus bridging the two particles.", "output": {"entities": {"gene": [{"text": "U5", "start": 183, "end": 185}, {"text": "U4", "start": 190, "end": 192}, {"text": "U6", "start": 193, "end": 195}]}}, "schema": []}
{"input": "Antibodies raised against a C-terminal portion of Sec31A co-precipitate Sec13 and inhibit ER-Golgi transport of temperature-arrested vesicular stomatitis G protein in a semi-intact cell assay.", "output": {"entities": {"gene": [{"text": "Sec31A", "start": 50, "end": 56}, {"text": "Sec13", "start": 72, "end": 77}, {"text": "stomatitis G protein", "start": 143, "end": 163}]}}, "schema": []}
{"input": "Regulation of mitochondrial single-stranded DNA-binding protein gene expression links nuclear and mitochondrial DNA replication in drosophila.", "output": {"entities": {}}, "schema": []}
{"input": "Genetic and molecular complexity of the position effect variegation modifier mod (mdg4) in Drosophila. mod (mdg4), also known as E (var) 3-93D, is involved in a variety of processes, such as gene silencing in position effect variegation (PEV), the control of gypsy insulator sequences, regulation of homeotic gene expression, and programmed cell death.", "output": {"entities": {"gene": [{"text": "modifier", "start": 68, "end": 76}, {"text": "mdg4", "start": 82, "end": 86}, {"text": "mod", "start": 103, "end": 106}, {"text": "mdg4", "start": 108, "end": 112}, {"text": "E (var) 3-93D", "start": 129, "end": 142}, {"text": "gypsy insulator sequences", "start": 259, "end": 284}, {"text": "homeotic gene", "start": 300, "end": 313}]}}, "schema": []}
{"input": "They are present in many kinds of living things, but their functions, especially those in humans, are unclear.", "output": {"entities": {}}, "schema": []}
{"input": "This tendency is likely due to the biased nucleotide composition of the asparagus genome, rather than to the translational selection for specific codons.", "output": {"entities": {}}, "schema": []}
{"input": "Transduction of the human leukemic cell line K562 showed that viral MRP1-PG13 supernatants routinely transfer the MRP1 gene to approximately 35% of target K562 cells, of which at least one third are capable of proliferating in the presence of otherwise toxic concentrations of etoposide.", "output": {"entities": {"gene": [{"text": "MRP1", "start": 68, "end": 72}, {"text": "MRP1 gene", "start": 114, "end": 123}]}}, "schema": []}
{"input": "Regulation of pituitary vasopressin V1b receptors plays a critical role in regulating pituitary adrenocorticotropic hormone (ACTH) secretion during adaptation to stress.", "output": {"entities": {"gene": [{"text": "vasopressin V1b receptors", "start": 24, "end": 49}, {"text": "pituitary adrenocorticotropic hormone", "start": 86, "end": 123}, {"text": "ACTH", "start": 125, "end": 129}]}}, "schema": []}
{"input": "Identification of an AfsA homologue (BarX) from Streptomyces virginiae as a pleiotropic regulator controlling autoregulator biosynthesis, virginiamycin biosynthesis and virginiamycin M1 resistance.", "output": {"entities": {"gene": [{"text": "AfsA homologue", "start": 21, "end": 35}, {"text": "BarX", "start": 37, "end": 41}]}}, "schema": []}
{"input": "Given its relative longevity on the Web, TIE researchers have been in a unique position to observe trends in telemedicine.", "output": {"entities": {}}, "schema": []}
{"input": "Cerebral vasculitis secondary to Crohn' s disease seems to be a very rare phenomenon.", "output": {"entities": {}}, "schema": []}
{"input": "To test the hypothesis that progestin-mediated increases in resting core temperature and the core temperature threshold for sweating onset are counteracted by estrogen, we studied eight women (24 +/-2 yr) at 27 degrees C rest, during 20 min of passive heating (35 degrees C), and during 40 min of exercise at 35 degrees C.", "output": {"entities": {}}, "schema": []}
{"input": "Our data show also that phagocytic killing of meningococci is probably a more consistent assay than antibody titer levels for antimeningococcal immunity, especially in LCC-deficient patients.", "output": {"entities": {}}, "schema": []}
{"input": "These studies suggest an additional component or cellular environment is required for SPRK activation by Cdc42.", "output": {"entities": {"gene": [{"text": "SPRK", "start": 86, "end": 90}, {"text": "Cdc42", "start": 105, "end": 110}]}}, "schema": []}
{"input": "M.", "output": {"entities": {}}, "schema": []}
{"input": "Jkappa DNA-binding sites were not required for this activation, and a mutant EBNA-3C protein unable to bind Jkappa activated transcription as efficiently as wild-type EBNA-3C, indicating that EBNA-3C can regulate transcription through a mechanism that is independent of Jkappa.", "output": {"entities": {"gene": [{"text": "Jkappa DNA-binding sites", "start": 0, "end": 24}, {"text": "mutant EBNA-3C protein", "start": 70, "end": 92}, {"text": "Jkappa", "start": 108, "end": 114}, {"text": "wild-type EBNA-3C", "start": 157, "end": 174}, {"text": "EBNA-3C", "start": 192, "end": 199}, {"text": "Jkappa", "start": 270, "end": 276}]}}, "schema": []}
{"input": "Thus, both YY1 and CDP appear to be negative regulators of the differentiation-induced HPV-6 E1 promoter and thereby the HPV life cycle.", "output": {"entities": {"gene": [{"text": "YY1", "start": 11, "end": 14}, {"text": "CDP", "start": 19, "end": 22}, {"text": "HPV-6 E1 promoter", "start": 87, "end": 104}]}}, "schema": []}
{"input": "Sequential cleavage by metallopeptidases and proteasomes is involved in processing HIV-1 ENV epitope for endogenous MHC class I antigen presentation.", "output": {"entities": {"gene": [{"text": "metallopeptidases", "start": 23, "end": 40}, {"text": "HIV-1 ENV epitope", "start": 83, "end": 100}, {"text": "MHC class I antigen", "start": 116, "end": 135}]}}, "schema": []}
{"input": "Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation.", "output": {"entities": {"gene": [{"text": "human Lnk", "start": 32, "end": 41}, {"text": "pleckstrin", "start": 67, "end": 77}, {"text": "Src homology 2 domains", "start": 91, "end": 113}]}}, "schema": []}
{"input": "Vancomycin data were analyzed according to a one-compartment open model with use of NONMEM population pharmacokinetic software.", "output": {"entities": {}}, "schema": []}
{"input": "Finally, Cas existed mainly in cytosol and membrane cytoskeleton fractions in the resting state, and remained unchanged during platelet aggregation, when FAK translocated to the cytoskeletal fraction.", "output": {"entities": {"gene": [{"text": "Cas", "start": 9, "end": 12}, {"text": "FAK", "start": 154, "end": 157}]}}, "schema": []}
{"input": "Transcriptional regulation of the yeast PHO8 promoter in comparison to the coregulated PHO5 promoter.", "output": {"entities": {"gene": [{"text": "yeast PHO8 promoter", "start": 34, "end": 53}, {"text": "PHO5 promoter", "start": 87, "end": 100}]}}, "schema": []}
{"input": "The Siglecs are a subfamily of I-type lectins (immunoglobulin superfamily proteins that bind sugars) that specifically recognize sialic acids.", "output": {"entities": {"gene": [{"text": "Siglecs", "start": 4, "end": 11}, {"text": "I-type lectins", "start": 31, "end": 45}, {"text": "immunoglobulin superfamily proteins", "start": 47, "end": 82}]}}, "schema": []}
{"input": "Our data provide a biochemical explanation for the similarity in phenotype between A-T and NBS.", "output": {"entities": {}}, "schema": []}
{"input": "PATIENTS OR OTHER PARTICIPANTS: Twenty children met the criteria for being learning disabled.", "output": {"entities": {}}, "schema": []}
{"input": "Update on maternal-fetal infections by hepatitis C, HIV and cytomegalovirus", "output": {"entities": {}}, "schema": []}
{"input": "In the present study, we characterized cis-elements of the human PCI gene required for expression in the hepatoma-derived cell line, HepG2 cells, and also evaluated rat PCI mRNA expression, particularly on the effect of androgen in rat reproductive tissues.", "output": {"entities": {"gene": [{"text": "human PCI gene", "start": 59, "end": 73}, {"text": "rat PCI mRNA", "start": 165, "end": 177}]}}, "schema": []}
{"input": "In the study on PCI mRNA expression in the reproductive organs, we first cloned rat PCI cDNA and then evaluated the effect of androgen on the PCI mRNA expression.", "output": {"entities": {"gene": [{"text": "PCI mRNA", "start": 16, "end": 24}, {"text": "rat PCI cDNA", "start": 80, "end": 92}, {"text": "PCI mRNA", "start": 142, "end": 150}]}}, "schema": []}
{"input": "The stoichiometry of the complexes formed with the dodeca-satellite C strand suggests that, in DDP1, the 15 consecutive KH domains are organized such that they define two nucleic acid binding surfaces.", "output": {"entities": {"gene": [{"text": "DDP1", "start": 95, "end": 99}]}}, "schema": []}
{"input": "Mutational analysis of mammalian translation initiation factor 5 (eIF5): role of interaction between the beta subunit of eIF2 and eIF5 in eIF5 function in vitro and in vivo.", "output": {"entities": {"gene": [{"text": "mammalian translation initiation factor 5", "start": 23, "end": 64}, {"text": "eIF5", "start": 66, "end": 70}, {"text": "eIF2", "start": 121, "end": 125}, {"text": "eIF5", "start": 130, "end": 134}, {"text": "eIF5", "start": 138, "end": 142}]}}, "schema": []}
{"input": "Much evidence indicates that p38 is an activator of MyoD: (i) p38 kinase activity is required for the expression of MyoD-responsive genes, (ii) enforced induction of p38 stimulates the transcriptional activity of a Gal4-MyoD fusion protein and allows efficient activation of chromatin-integrated reporters by MyoD, and (iii) MyoD-dependent myogenic conversion is reduced in mouse embryonic fibroblasts derived from p38alpha (-/-) embryos.", "output": {"entities": {"gene": [{"text": "p38", "start": 29, "end": 32}, {"text": "MyoD", "start": 52, "end": 56}, {"text": "p38 kinase", "start": 62, "end": 72}, {"text": "MyoD", "start": 116, "end": 120}, {"text": "p38", "start": 166, "end": 169}, {"text": "Gal4", "start": 215, "end": 219}, {"text": "MyoD", "start": 220, "end": 224}, {"text": "MyoD", "start": 309, "end": 313}, {"text": "MyoD", "start": 325, "end": 329}, {"text": "p38alpha (-/-)", "start": 415, "end": 429}]}}, "schema": []}
{"input": "This activity is stimulated by complex formation with the other eIF2B subunits.", "output": {"entities": {"gene": [{"text": "eIF2B subunits", "start": 64, "end": 78}]}}, "schema": []}
{"input": "Our analysis of nonsense mutations indicates that the C terminus of eIF2Bepsilon (residues 518 to 712) is required for both catalytic activity and interaction with eIF2.", "output": {"entities": {"gene": [{"text": "eIF2Bepsilon (residues 518 to 712)", "start": 68, "end": 102}, {"text": "eIF2", "start": 164, "end": 168}]}}, "schema": []}
{"input": "In contrast, mutations affecting the other two Nim1p-related kinases in S. cerevisiae, Hsl1p and Kcc4p, produce no detectable effect on septin organization.", "output": {"entities": {"gene": [{"text": "Nim1p-related kinases", "start": 47, "end": 68}, {"text": "Hsl1p", "start": 87, "end": 92}, {"text": "Kcc4p", "start": 97, "end": 102}, {"text": "septin", "start": 136, "end": 142}]}}, "schema": []}
{"input": "CONCLUSIONS: Physiologic pacing provides little benefit over ventricular pacing for the prevention of stroke or death due to cardiovascular causes.", "output": {"entities": {}}, "schema": []}
{"input": "Among non-cirrhotics, lack of portal vein visualisation had a 90% sensitivity, 88% specificity, 94% negative predictive value, and 83% positive predictive value in the diagnosis of pre-sinusoidal portal hypertension.", "output": {"entities": {}}, "schema": []}
{"input": "The serine-threonine kinase gene is likely functional, whereas the zinc finger motif is likely nonfunctional.", "output": {"entities": {"gene": [{"text": "serine-threonine kinase gene", "start": 4, "end": 32}]}}, "schema": []}
{"input": "Stat activation in response to GH and IL-6 was determined by reporter gene induction.", "output": {"entities": {"gene": [{"text": "Stat", "start": 0, "end": 4}, {"text": "GH", "start": 31, "end": 33}, {"text": "IL-6", "start": 38, "end": 42}]}}, "schema": []}
{"input": "HFA 134a had a greater tendency to take up moisture from the environment than did HFA 227.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: Abnormal color perception was found in 32% of the epilepsy patients treated with vigabatrin monotherapy and 28% of the epilepsy patients treated with carbamazepine monotherapy.", "output": {"entities": {}}, "schema": []}
{"input": "In the SPP2 screening test, a few plates were not seen in both groups.", "output": {"entities": {}}, "schema": []}
{"input": "Mitogen-activated protein (MAP) kinase phosphatase-3 (MKP-3) is a dual specificity phosphatase that inactivates extracellular signal-regulated kinase (ERK) MAP kinases.", "output": {"entities": {"gene": [{"text": "Mitogen-activated protein (MAP) kinase phosphatase-3", "start": 0, "end": 52}, {"text": "MKP-3", "start": 54, "end": 59}, {"text": "extracellular signal-regulated kinase", "start": 112, "end": 149}, {"text": "ERK", "start": 151, "end": 154}, {"text": "MAP kinases", "start": 156, "end": 167}]}}, "schema": []}
{"input": "Consistent with this, we show that peptides representing docking sites within the target substrates Elk-1 and p90 (rsk) inhibit ERK-dependent activation of MKP-3.", "output": {"entities": {"gene": [{"text": "Elk-1", "start": 100, "end": 105}, {"text": "p90", "start": 110, "end": 113}, {"text": "rsk", "start": 115, "end": 118}, {"text": "ERK", "start": 128, "end": 131}, {"text": "MKP-3", "start": 156, "end": 161}]}}, "schema": []}
{"input": "HPLC phosphopeptide mapping, amino acid sequencing, and site-directed mutagenesis determined that NCLK phosphorylates Ser (67) of I-1.", "output": {"entities": {"gene": [{"text": "NCLK", "start": 98, "end": 102}, {"text": "I-1", "start": 130, "end": 133}]}}, "schema": []}
{"input": "When the entire diet consisted of SBF, voluntary feed intake was reduced, indicating that SBF should not be fed to ponies as the sole dietary ingredient.", "output": {"entities": {}}, "schema": []}
{"input": "Hepatitis C virus infection and lymphoproliferative diseases in France: a national study.", "output": {"entities": {}}, "schema": []}
{"input": "Interestingly, a decreased transcription from the endogenous c-Myb promoter was observed in several HTLV-I transformed T-cell lines.", "output": {"entities": {"gene": [{"text": "c-Myb promoter", "start": 61, "end": 75}]}}, "schema": []}
{"input": "H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19.", "output": {"entities": {"gene": [{"text": "H19", "start": 0, "end": 3}, {"text": "Igf2", "start": 8, "end": 12}, {"text": "H19", "start": 123, "end": 126}]}}, "schema": []}
{"input": "C. elegans KLP-11/OSM-3/KAP-1: orthologs of the sea urchin kinesin-II, and mouse KIF3A/KIFB/KAP3 kinesin complexes.", "output": {"entities": {"gene": [{"text": "KLP-11", "start": 11, "end": 17}, {"text": "OSM-3", "start": 18, "end": 23}, {"text": "KAP-1", "start": 24, "end": 29}, {"text": "sea urchin kinesin-II", "start": 48, "end": 69}, {"text": "KIF3A", "start": 81, "end": 86}, {"text": "KIFB", "start": 87, "end": 91}, {"text": "KAP3 kinesin", "start": 92, "end": 104}]}}, "schema": []}
{"input": "BACKGROUND: Hepatic encephalopathy is a neuropsychiatric syndrome associated with acute liver failure, chronic parenchymal liver disease or portal systemic anastomosis.", "output": {"entities": {}}, "schema": []}
{"input": "These natural antisense S transcripts co-exist with several less abundant sense S transcripts.", "output": {"entities": {"gene": [{"text": "S transcripts", "start": 24, "end": 37}, {"text": "S transcripts", "start": 80, "end": 93}]}}, "schema": []}
{"input": "Nor is such adjustment possible unless one posits a model that relates the missing observations to other observed information for each subject-models that are inherently untestable.", "output": {"entities": {}}, "schema": []}
{"input": "However, the presence of effacement seems to be a more reliable and practical parameter that will be preferred in that prediction.", "output": {"entities": {}}, "schema": []}
{"input": "The data are compatible with the idea that YLL031c transfers the ethanolaminephosphate to the inner alpha1-2-linked mannose, i. e. the group that links the GPI lipid anchor to proteins, whereas Mcd4p and Gpi7p transfer ethanolaminephosphate onto the alpha1-4-and alpha1-6-linked mannoses of the GPI anchor, respectively.", "output": {"entities": {"gene": [{"text": "YLL031c", "start": 43, "end": 50}, {"text": "Mcd4p", "start": 194, "end": 199}, {"text": "Gpi7p", "start": 204, "end": 209}]}}, "schema": []}
{"input": "The C terminus of TRBP binds to CBP/p300 and DRIP130, a component of the DRIP/TRAP/ARC complex, which suggests that TRBP may activate transcription by means of such interactions.", "output": {"entities": {"gene": [{"text": "TRBP", "start": 18, "end": 22}, {"text": "CBP", "start": 32, "end": 35}, {"text": "p300", "start": 36, "end": 40}, {"text": "DRIP130", "start": 45, "end": 52}, {"text": "DRIP", "start": 73, "end": 77}, {"text": "TRAP", "start": 78, "end": 82}, {"text": "ARC", "start": 83, "end": 86}, {"text": "TRBP", "start": 116, "end": 120}]}}, "schema": []}
{"input": "The patients who presented with mucocutaneous disease also had low CD4 + T lymphocyte counts, and most of them had AIDS defining illnesses.", "output": {"entities": {"gene": [{"text": "CD4 +", "start": 67, "end": 72}]}}, "schema": []}
{"input": "Increased dietary energy decreased PAB and the use of added dietary CO rather than PF decreased PSHL in broiler breeders between 26 and 47 wk of age.", "output": {"entities": {}}, "schema": []}
{"input": "The gene amplification model of Coquelle et al.", "output": {"entities": {}}, "schema": []}
{"input": "Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation.", "output": {"entities": {"gene": [{"text": "protein tyrosine kinases", "start": 13, "end": 37}, {"text": "interleukin-2", "start": 41, "end": 54}, {"text": "IL-2", "start": 56, "end": 60}, {"text": "syk", "start": 87, "end": 90}, {"text": "Jak3", "start": 102, "end": 106}, {"text": "Syk", "start": 125, "end": 128}, {"text": "Lck", "start": 133, "end": 136}, {"text": "IL-2", "start": 153, "end": 157}, {"text": "STAT", "start": 167, "end": 171}]}}, "schema": []}
{"input": "Immobilized dimers of N-cadherin-Fc chimera mimic cadherin-mediated cell contact formation: contribution of both outside-in and inside-out signals.", "output": {"entities": {"gene": [{"text": "N-cadherin", "start": 22, "end": 32}, {"text": "Fc", "start": 33, "end": 35}]}}, "schema": []}
{"input": "The monoclonal immunoglobulin products of plasma cell neoplasm can give rise to a variety of manifestations including hyperviscosity, amyloidosis, cryoglobulinemia, neuropathy, and renal failure.", "output": {"entities": {"gene": [{"text": "immunoglobulin", "start": 15, "end": 29}]}}, "schema": []}
{"input": "Investigation of the structural basis of the interaction between human Igs and gp120 shows that the viral gp120 SAg can interact only with a subset of human V (H) 3 + Igs.", "output": {"entities": {"gene": [{"text": "human Igs", "start": 65, "end": 74}, {"text": "gp120", "start": 79, "end": 84}, {"text": "viral gp120 SAg", "start": 100, "end": 115}, {"text": "human V (H) 3 + Igs", "start": 151, "end": 170}]}}, "schema": []}
{"input": "Double-blind, placebo-controlled trial.", "output": {"entities": {}}, "schema": []}
{"input": "Here, it is shown that TAFII250, the largest subunit of TFIID, contains two tandem bromodomain modules that bind selectively to multiply acetylated histone H4 peptides.", "output": {"entities": {"gene": [{"text": "TAFII250", "start": 23, "end": 31}, {"text": "TFIID", "start": 56, "end": 61}, {"text": "histone H4 peptides", "start": 148, "end": 167}]}}, "schema": []}
{"input": "Endostatin treatment for 10 minutes or 24 hours induced tyrosine phosphorylation of Shb and formation of multiprotein complexes.", "output": {"entities": {"gene": [{"text": "Shb", "start": 84, "end": 87}]}}, "schema": []}
{"input": "The transcript was initially identified as a partial cDNA sequence in the course of constructing a transcript map of the region between markers D11S1765 and uteroglobin known to encompass the gene causing Best disease.", "output": {"entities": {"gene": [{"text": "D11S1765", "start": 144, "end": 152}, {"text": "uteroglobin", "start": 157, "end": 168}]}}, "schema": []}
{"input": "The real challenge for the future will be the management of patients who do not respond to first-line treatment.", "output": {"entities": {}}, "schema": []}
{"input": "Iodine deficiency disorders in Bangladesh.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: Soluble CD23 levels were significantly higher in women with endometriosis before treatment than in ten normal controls.", "output": {"entities": {"gene": [{"text": "CD23", "start": 17, "end": 21}]}}, "schema": []}
{"input": "CONCLUSION: Our findings suggest that endometriosis increases soluble CD23 levels, which can be suppressed with either danazol or leuprolide acetate injection.", "output": {"entities": {"gene": [{"text": "CD23", "start": 70, "end": 74}]}}, "schema": []}
{"input": "To isolate this gene, a P-1 artificial chromosome (PAC) library was screened with a full length UGT2B7 probe and a clone of approximately 100 kb in length was isolated.", "output": {"entities": {"gene": [{"text": "full length UGT2B7", "start": 84, "end": 102}]}}, "schema": []}
{"input": "Age >/= 50 years (odds ratio [OR], 14. 1), BMI >/= 28 kg/m (2) (OR, 5. 7), triglycerides >/= 1. 7 mmol/L (OR, 5), and alanine aminotransferase (ALT) >/= 2N (OR, 4. 6) were independently associated with septal fibrosis.", "output": {"entities": {"gene": [{"text": "alanine aminotransferase", "start": 118, "end": 142}, {"text": "ALT", "start": 144, "end": 147}]}}, "schema": []}
{"input": "However, the elderly group showed significantly longer mean residence times (MRTs) and lower plasma clearance of lidocaine during the period compared with the adult group (P <. 05).", "output": {"entities": {}}, "schema": []}
{"input": "Here, we show that the zinc finger protein Gis1 acts as a dosage-dependent suppressor of the rim15Delta defect in nutrient limitation-induced transcriptional derepression of SSA3.", "output": {"entities": {"gene": [{"text": "zinc finger protein Gis1", "start": 23, "end": 47}, {"text": "rim15Delta", "start": 93, "end": 103}, {"text": "SSA3", "start": 174, "end": 178}]}}, "schema": []}
{"input": "The so-called \" SH3 \" segment of the linker domain, in contrast, shows species-specific sequence identity in all but one amino acid residues in both factors, in cattle, human, and mouse.", "output": {"entities": {"gene": [{"text": "\" SH3 \" segment", "start": 14, "end": 29}]}}, "schema": []}
{"input": "No differences in total cholesterol levels were observed between mapuches and aymaras.", "output": {"entities": {}}, "schema": []}
{"input": "Up to 95% of the total UV exposure received is in the UV-A waveband (320-400 nm).", "output": {"entities": {}}, "schema": []}
{"input": "To begin to characterize the role of the RNA subunits in enzyme function and substrate specificity, we swapped two hairpin structures (MRP3 and P3) between RNase MRP RNA and RNase P RNA of S. cerevisiae.", "output": {"entities": {"gene": [{"text": "RNase MRP RNA", "start": 156, "end": 169}, {"text": "RNase P RNA of S. cerevisiae", "start": 174, "end": 202}]}}, "schema": []}
{"input": "Among genes induced by added pMesogenin1 is Xwnt-8, a signaling factor that induces a similar repertoire of marker genes and a similar cellular phenotype.", "output": {"entities": {"gene": [{"text": "pMesogenin1", "start": 29, "end": 40}, {"text": "Xwnt-8", "start": 44, "end": 50}]}}, "schema": []}
{"input": "Accordingly, no Ha-ras codon 12 mutations are found in the EtNU-induced mammary tumors.", "output": {"entities": {"gene": [{"text": "Ha-ras codon 12", "start": 16, "end": 31}]}}, "schema": []}
{"input": "False positive PET FDG corresponded to lung infection, degenerative bone disease, and reconstruction artifact.", "output": {"entities": {}}, "schema": []}
{"input": "Tumor stages were IIB (T3 N0) in 52%, IIIA in 15%, and IIIB in 27% of patients.", "output": {"entities": {}}, "schema": []}
{"input": "Similarly, comparison of percentage reductions of heart rate at supine, sitting and exercise by repeated measure analysis showed the Malays to have significantly higher change compared to the Chinese (p = 0. 040).", "output": {"entities": {}}, "schema": []}
{"input": "Consistent with our model, CTCF binding is abolished by DNA methylation.", "output": {"entities": {"gene": [{"text": "CTCF", "start": 27, "end": 31}]}}, "schema": []}
{"input": "OBJECTIVE: To determine the efficacy and safety of amphotericin B oral suspension (ABOS) for the treatment of fluconazole refractory oral candidiasis in persons with HIV infection.", "output": {"entities": {}}, "schema": []}
{"input": "The experimentally mapped regions of RPB5 involved in these interactions correspond to distinct and surface-exposed alpha-helical structures.", "output": {"entities": {"gene": [{"text": "RPB5", "start": 37, "end": 41}]}}, "schema": []}
{"input": "The model indicates that a 0. 076% reduction in cigarette consumption is associated with the availability of nicotine patches after 1992.", "output": {"entities": {}}, "schema": []}
{"input": "Paper alert.", "output": {"entities": {}}, "schema": []}
{"input": "The tryptase locus also contains at least four tryptase-like pseudogenes, including mastin, a gene expressed in dogs but not in humans.", "output": {"entities": {"gene": [{"text": "tryptase locus", "start": 4, "end": 18}, {"text": "tryptase-like pseudogenes", "start": 47, "end": 72}, {"text": "mastin", "start": 84, "end": 90}]}}, "schema": []}
{"input": "The cellular part of the third chimeric clone shows significant homology to an exon of the human tyrosine phosphatase 1 gene, although oriented in the antisense direction compared to the adjacent LTR.", "output": {"entities": {"gene": [{"text": "human tyrosine phosphatase 1 gene", "start": 91, "end": 124}]}}, "schema": []}
{"input": "OBJECTIVE: This study was conducted to assess the relative roles of 99mTc-sestamibi scintimammography and sonography in the evaluation of breast lesions that are indeterminate or suspicious on mammography or clinical examination.", "output": {"entities": {}}, "schema": []}
{"input": "Mutational analyses showed that in-frame stop codons introduced into five of seven RNA 2 ORFs did not affect accumulation of progeny LIYV RNA 1 or RNA 2, confirming that RNA 2 does not encode proteins necessary for LIYV RNA replication.", "output": {"entities": {"gene": [{"text": "RNA 2 ORFs", "start": 83, "end": 93}, {"text": "LIYV RNA 1", "start": 133, "end": 143}, {"text": "RNA 2", "start": 147, "end": 152}, {"text": "RNA 2", "start": 170, "end": 175}]}}, "schema": []}
{"input": "Role of NH (2)-and COOH-terminal domains of the P protein of human parainfluenza virus type 3 in transcription and replication.", "output": {"entities": {"gene": [{"text": "P protein", "start": 48, "end": 57}]}}, "schema": []}
{"input": "Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors.", "output": {"entities": {"gene": [{"text": "Eph receptors", "start": 136, "end": 149}]}}, "schema": []}
{"input": "RESULTS: Fournier' s gangrene occurs worldwide.", "output": {"entities": {}}, "schema": []}
{"input": "Genomic DNA sequencing in the vicinity of methylmalonyl-CoA mutase gene (mutAB) from a rifamycin SV-producing Amycolatopsis mediterranei U32 allowed us to clone, sequence, and identify a gene encoding a novel serine/threonine protein kinase (amk).", "output": {"entities": {"gene": [{"text": "methylmalonyl-CoA mutase gene", "start": 42, "end": 71}, {"text": "mutAB", "start": 73, "end": 78}, {"text": "serine/threonine protein kinase", "start": 209, "end": 240}, {"text": "amk", "start": 242, "end": 245}]}}, "schema": []}
{"input": "IL-2 is accepted as a standard treatment used alone, or in combination with chemotherapy or biotherapy in the management of metastatic melanoma and metastatic renal cell carcinoma.", "output": {"entities": {"gene": [{"text": "IL-2", "start": 0, "end": 4}]}}, "schema": []}
{"input": "Moreover, expression of antisense Ha-Ras or dominant negative Raf-1 abrogated the mitogenic effect of TGF-beta1 in TSU-Pr1, and the TGF-beta1 inhibition of DU145 was switched to stimulation by V12Ha-Ras transfection.", "output": {"entities": {"gene": [{"text": "antisense Ha-Ras", "start": 24, "end": 40}, {"text": "dominant negative Raf-1", "start": 44, "end": 67}, {"text": "TGF-beta1", "start": 102, "end": 111}, {"text": "TGF-beta1", "start": 132, "end": 141}, {"text": "V12Ha-Ras", "start": 193, "end": 202}]}}, "schema": []}
{"input": "Taken together, our data suggest that prostate carcinomas with the Ras/MAPK pathway activation might have a selective growth advantage by autocrine TGF-beta1 production.", "output": {"entities": {"gene": [{"text": "Ras", "start": 67, "end": 70}, {"text": "MAPK", "start": 71, "end": 75}, {"text": "TGF-beta1", "start": 148, "end": 157}]}}, "schema": []}
{"input": "Vbeta segments are appended to DJbeta rearrangements, with little or no direct Vbeta to Jbeta joining, despite 12/23 compatibility of Vbeta 23-RSSs and Jbeta12-RSSs.", "output": {"entities": {"gene": [{"text": "Vbeta", "start": 0, "end": 5}, {"text": "DJbeta", "start": 31, "end": 37}, {"text": "Vbeta", "start": 79, "end": 84}, {"text": "Jbeta", "start": 88, "end": 93}, {"text": "Vbeta 23-RSSs", "start": 134, "end": 147}, {"text": "Jbeta12-RSSs", "start": 152, "end": 164}]}}, "schema": []}
{"input": "For oral administration, AUC0-infinity was 58. 47 +/-16. 37 microg x h/ml, t1/2beta was 18. 39 +/-0. 06 hours, maximum concentration (Cmax) was 2. 12 +/-00. 51 microg/ml, time to Cmax was 2. 20 +/-2. 17 hours, mean absorption time was 2. 09 +/-0. 51 hours, and bioavailability was 42 +/-0. 42%.", "output": {"entities": {}}, "schema": []}
{"input": "In experiment 2, no difference in gastric emptying of 40% peptone or 25% glucose was found between rats receiving TPN and those receiving intragastric nutrition for 10 to 12 days.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast, H-NS negative regulation operated only in the absence of Fur.", "output": {"entities": {"gene": [{"text": "H-NS", "start": 13, "end": 17}, {"text": "Fur", "start": 70, "end": 73}]}}, "schema": []}
{"input": "Thus, SAG appears to control cell cycle progression in yeast by promoting ubiquitination and degradation of cell cycle regulatory proteins.", "output": {"entities": {"gene": [{"text": "SAG", "start": 6, "end": 9}]}}, "schema": []}
{"input": "It brings about fatigue, negative moods, and impaired health, sleep, safety, and working capacity.", "output": {"entities": {}}, "schema": []}
{"input": "This demonstrates that treatment of the graft recipient for a relatively short period during and after surgery has a favorable effect on the survival of grafted dopaminergic neurons.", "output": {"entities": {}}, "schema": []}
{"input": "The relationships among blood concentrations of thyroid hormones and selenium, zinc, retinol, and alpha-tocopherol were studied in 44 healthy Northern Italian oldest-old subjects (age range, 90-107 yr), selected by the criteria of the SENIEUR protocol.", "output": {"entities": {}}, "schema": []}
{"input": "Chinese Spring (CS) carrying the Q gene to those of a chromosome deletion line of CS, namely, q5, which lacks 15% of 5AL including the Q gene.", "output": {"entities": {"gene": [{"text": "Q gene", "start": 33, "end": 39}, {"text": "Q gene", "start": 135, "end": 141}]}}, "schema": []}
{"input": "Investigations using hippocampal slices maintained in vitro have demonstrated that bursts of oscillatory field potentials in the gamma frequency range (30-80 Hz) are followed by a slower oscillation in the beta 1 range (12-20 Hz).", "output": {"entities": {}}, "schema": []}
{"input": "Karger AG, Basel", "output": {"entities": {}}, "schema": []}
{"input": "During surgery bone cysts were excised and filled by bone grafts.", "output": {"entities": {}}, "schema": []}
{"input": "Urinary LTE4 increased after both challenges the rise being higher following oral as compared to inhalation provocation (p = 0. 0001).", "output": {"entities": {}}, "schema": []}
{"input": "Basal FVR was reduced by approximately 18% by ERT and HRT, but FVR responses to noradrenaline, angiotensin II, acetylcholine and nitroprusside were unaffected.", "output": {"entities": {"gene": [{"text": "angiotensin II", "start": 95, "end": 109}]}}, "schema": []}
{"input": "Three FGF-AS cDNAs were isolated; the full-length FGF-AS mRNA and two alternative splice variants lacking exon 2 or exons 2 and 3 of the FGF-AS sequence.", "output": {"entities": {"gene": [{"text": "FGF-AS cDNAs", "start": 6, "end": 18}, {"text": "full-length FGF-AS mRNA", "start": 38, "end": 61}, {"text": "FGF-AS sequence", "start": 137, "end": 152}]}}, "schema": []}
{"input": "Characterization of polymorphic TNRs in novel and even known genes expressed in human spinal cord is likely to help in the identification of new candidates for genes involved in neurodegenerative disorders.", "output": {"entities": {}}, "schema": []}
{"input": "Finally, in situ RNA hybridization studies revealed a very specific pattern of EphA8 gene expression restricted to the rostral region of midbrain tectum during embryonic development.", "output": {"entities": {"gene": [{"text": "EphA8 gene", "start": 79, "end": 89}]}}, "schema": []}
{"input": "Transfection of cDNAs for three mutant enzymes into FPGS-null Chinese hamster ovary cells restored a reduced level of clonal growth, whereas a T339I mutant supported growth at a level comparable to that of the wild-type enzyme.", "output": {"entities": {"gene": [{"text": "FPGS", "start": 52, "end": 56}]}}, "schema": []}
{"input": "SETTING: University of Paris VII hospital. Patient (s): Nine women had embolization for symptomatic myoma, with 12 pregnancies observed.", "output": {"entities": {}}, "schema": []}
{"input": "Improving fissure sealant quality: mechanical preparation and filling level.", "output": {"entities": {}}, "schema": []}
{"input": "The Menopause-Rating-Scale (MRS I) was used in clinical practice since 1992.", "output": {"entities": {}}, "schema": []}
{"input": "The MRS II meets a high methodological standard as an instrument standardized in the population.", "output": {"entities": {}}, "schema": []}
{"input": "The protein encoded by the fruA transcript is well conserved with the D. melanogaster type A protein, particularly the BTB protein-protein-binding domain, which is encoded by exons I and II and is 100% conserved.", "output": {"entities": {"gene": [{"text": "fruA transcript", "start": 27, "end": 42}, {"text": "D. melanogaster type A protein", "start": 70, "end": 100}, {"text": "BTB protein", "start": 119, "end": 130}]}}, "schema": []}
{"input": "In addition, the mouse ortholog (Mharp/Smarcal1) was cloned, and the Caenorhabditis elegans ortholog (CEHARP) was identified in the GenBank database.", "output": {"entities": {"gene": [{"text": "Mharp", "start": 33, "end": 38}, {"text": "Smarcal1", "start": 39, "end": 47}, {"text": "CEHARP", "start": 102, "end": 108}]}}, "schema": []}
{"input": "Sparfloxacin and clinafloxacin were evaluated against Enterococcus faecium SF2149 and Enterococcus faecalis WH245, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "ECP and tryptase levels in serum were measured before and after the last oral challenge.", "output": {"entities": {"gene": [{"text": "ECP", "start": 0, "end": 3}, {"text": "tryptase", "start": 8, "end": 16}]}}, "schema": []}
{"input": "Tolterodine users were 7. 5 times more likely to have received another spasmolytic drug (RR 7. 5, 95% CI 4. 8 to 11. 9).", "output": {"entities": {}}, "schema": []}
{"input": "For an unsupervised program, the costs were estimated at $311 for the first year and $73 for all additional years.", "output": {"entities": {}}, "schema": []}
{"input": "The presence of such a putative RNA-binding domain suggests a mechanism for the observed autoregulation of bacteriophage T4 DNA polymerase synthesis by binding to its own mRNA.", "output": {"entities": {"gene": [{"text": "T4 DNA polymerase", "start": 121, "end": 138}]}}, "schema": []}
{"input": "Deletion and mutational analyses revealed two positive cis-regulatory elements in this region that are essential for CSX1 expression in cardiomyocytes.", "output": {"entities": {"gene": [{"text": "CSX1", "start": 117, "end": 121}]}}, "schema": []}
{"input": "Functional studies which introduced a mutation in the AP2 core binding region as well as cotransfection experiments using an AP2 expression vector revealed that AP2 exerts a repressive role on the HGF gene promoter activity.", "output": {"entities": {"gene": [{"text": "AP2 core binding region", "start": 54, "end": 77}, {"text": "AP2", "start": 125, "end": 128}, {"text": "AP2", "start": 161, "end": 164}, {"text": "HGF gene promoter", "start": 197, "end": 214}]}}, "schema": []}
{"input": "In reconstitution experiments, we first showed that expression in the RAW 264. 7 cell line of C-terminal Src kinase (Csk) inhibited and that of a membrane-anchored, gain-of-function Csk abolished the Fc gamma R-mediated signaling that leads to phagocytosis in a kinase-dependent manner.", "output": {"entities": {"gene": [{"text": "C-terminal Src kinase", "start": 94, "end": 115}, {"text": "Csk", "start": 117, "end": 120}, {"text": "Csk", "start": 182, "end": 185}, {"text": "Fc gamma R", "start": 200, "end": 210}]}}, "schema": []}
{"input": "In contrast, c-Src-derived construct (a-Src), that was excluded from detergent-resistant membranes, could not restore the series of phagocytosis signaling.", "output": {"entities": {"gene": [{"text": "c-Src-derived construct", "start": 13, "end": 36}, {"text": "a-Src", "start": 38, "end": 43}]}}, "schema": []}
{"input": "The pJR vectors differ among them in: (a) the selectable marker (Saccharomyces cerevisiae LEU 2 gene, which complements S. pombe leu1-gene and S. pombe ura4 + and his3 + genes); (b) the thiamine-repressible nmt1 promoter (3X, 41X and 81X with extremely high, moderate or low transcription efficiency, respectively); and (c) the multiple cloning site (two multiple cloning sites, with 12 restriction sites each).", "output": {"entities": {"gene": [{"text": "LEU 2 gene", "start": 90, "end": 100}, {"text": "S. pombe leu1-gene", "start": 120, "end": 138}, {"text": "ura4 +", "start": 152, "end": 158}, {"text": "his3 + genes", "start": 163, "end": 175}, {"text": "nmt1 promoter", "start": 207, "end": 220}]}}, "schema": []}
{"input": "(GUT) Sera of 30 montoux negative healthy adults (age/sex matched) were taken as control by detecting IgG anti bodies to A60 antigen.", "output": {"entities": {"gene": [{"text": "IgG anti bodies", "start": 102, "end": 117}, {"text": "A60 antigen", "start": 121, "end": 132}]}}, "schema": []}
{"input": "Franz Schubert--his life, music and diseases", "output": {"entities": {}}, "schema": []}
{"input": "These results demonstrate that N-glycans flanking the receptor-binding site of the HA molecule are potent regulators of influenza virus growth, with the glycan at Asn149 being dominant and that at Asn123 being less effective.", "output": {"entities": {"gene": [{"text": "HA molecule", "start": 83, "end": 94}]}}, "schema": []}
{"input": "RESULTS: The introduction of the PAIP resulted in a significant (p < 0. 001) reduction in contaminating WBCs (median, 30, 000) from the numbers seen with FIP (median, 2, 300, 000) while maintaining the separation efficacy (47%) and separation time.", "output": {"entities": {}}, "schema": []}
{"input": "All were tested for serum ferritin (SF), hemoglobin (Hb) level and asked for detailed histories of donations and iron supplementation.", "output": {"entities": {"gene": [{"text": "ferritin", "start": 26, "end": 34}, {"text": "SF", "start": 36, "end": 38}, {"text": "hemoglobin", "start": 41, "end": 51}, {"text": "Hb", "start": 53, "end": 55}]}}, "schema": []}
{"input": "Vascular endothelial growth factor (VEGF), a potent agonist secreted by virtually all cells, controls migration and division of vascular endothelial cells.", "output": {"entities": {"gene": [{"text": "Vascular endothelial growth factor", "start": 0, "end": 34}, {"text": "VEGF", "start": 36, "end": 40}]}}, "schema": []}
{"input": "The antioxidant agent pyrrolidine dithiocarbamate (PDTC) has been shown to protect endothelial cells (EC) from pro-inflammatory-induced and pro-oxidant-induced NF-kappaB activation.", "output": {"entities": {"gene": [{"text": "NF-kappaB", "start": 160, "end": 169}]}}, "schema": []}
{"input": "We further studied the effects of SIE-1 hypermethylation on p21WAF1 induction by STAT activation.", "output": {"entities": {"gene": [{"text": "SIE-1", "start": 34, "end": 39}, {"text": "p21WAF1", "start": 60, "end": 67}, {"text": "STAT", "start": 81, "end": 85}]}}, "schema": []}
{"input": "In the pRb (-) SAOS-2 cell line transiently transfected with a reporter plasmid containing six tal-1 binding site, pRb enhances the transcriptional activity of tal-1-E12-Lmo2 and tal-1-E12-Lmo2-Ldb1 complexes but not that of a tal-1-E12 heterodimer.", "output": {"entities": {"gene": [{"text": "pRb (-)", "start": 7, "end": 14}, {"text": "tal-1 binding site", "start": 95, "end": 113}, {"text": "pRb", "start": 115, "end": 118}, {"text": "tal-1", "start": 160, "end": 165}, {"text": "E12", "start": 166, "end": 169}, {"text": "Lmo2", "start": 170, "end": 174}, {"text": "tal-1", "start": 179, "end": 184}, {"text": "E12", "start": 185, "end": 188}, {"text": "Lmo2", "start": 189, "end": 193}, {"text": "Ldb1", "start": 194, "end": 198}, {"text": "tal-1", "start": 227, "end": 232}, {"text": "E12", "start": 233, "end": 236}]}}, "schema": []}
{"input": "This effect was not seen in conjunction with oxycodone, a morphine-like mu-receptor agonist.", "output": {"entities": {"gene": [{"text": "morphine-like mu-receptor", "start": 58, "end": 83}]}}, "schema": []}
{"input": "Neurofibromatosis of the breast in a patient with Morbus von Recklinghausen", "output": {"entities": {}}, "schema": []}
{"input": "In the premating period male rate of aggression was not significantly correlated with testosterone level.", "output": {"entities": {}}, "schema": []}
{"input": "These results support the hypothesis that in the presence of tryptophan the ribosome translating tnaC blocks Rho' s access to the boxA and rut sites, thereby preventing transcription termination.", "output": {"entities": {"gene": [{"text": "tnaC", "start": 97, "end": 101}, {"text": "Rho", "start": 109, "end": 112}, {"text": "boxA", "start": 130, "end": 134}, {"text": "rut sites", "start": 139, "end": 148}]}}, "schema": []}
{"input": "In situ hybridization with the antisense RNA probes further supported the expression changes of these six clones and localized the changes in multiple germ cell stages as well as other cell types (Sertoli, interstitial and peritubular cells).", "output": {"entities": {}}, "schema": []}
{"input": "The administration of the GnRH agonist reduced the bone mineral density in the whole femur to 91. 0% of that in the control group.", "output": {"entities": {"gene": [{"text": "GnRH", "start": 26, "end": 30}]}}, "schema": []}
{"input": "This study shows that C/EBPbeta is the predominant C/EBP isoform found in activated stellate cells and that increased C/EBPbeta protein and C/EBPbeta binding to a proximal C/EBP binding site in the promoter mediates the activating effect of acetaldehyde.", "output": {"entities": {"gene": [{"text": "C/EBPbeta", "start": 22, "end": 31}, {"text": "C/EBP isoform", "start": 51, "end": 64}, {"text": "C/EBPbeta protein", "start": 118, "end": 135}, {"text": "C/EBPbeta", "start": 140, "end": 149}, {"text": "C/EBP binding site", "start": 172, "end": 190}]}}, "schema": []}
{"input": "As with VP16, the transactivation function of Luman is also regulated by HCF.", "output": {"entities": {"gene": [{"text": "VP16", "start": 8, "end": 12}, {"text": "Luman", "start": 46, "end": 51}, {"text": "HCF", "start": 73, "end": 76}]}}, "schema": []}
{"input": "After two successive rounds of selection by focus formation assay, a transforming ribozyme (Rz007) was identified.", "output": {"entities": {"gene": [{"text": "Rz007", "start": 92, "end": 97}]}}, "schema": []}
{"input": "G., and Hyde, C.", "output": {"entities": {}}, "schema": []}
{"input": "The ATR-X syndrome results from mutations of the XH2 gene, located on the X chromosome (Xq13. 3) and coding for a transacting factor which regulates gene expression.", "output": {"entities": {"gene": [{"text": "XH2 gene", "start": 49, "end": 57}]}}, "schema": []}
{"input": "AIMS: To evaluate the role of environmental intra-uterine factors in determining the birthweights of twins with increased susceptibility to diabetes and discordant for abnormal responses to the oral glucose tolerance test (OGTT) and verify the possible association of within-pair birthweight differences and metabolic abnormalities in adult life.", "output": {"entities": {}}, "schema": []}
{"input": "In NASCIS III, a randomization imbalance occurred that allocated a disproportionate number of patients with no motor deficit (and therefore no chance for recovery) to the lower dose control group.", "output": {"entities": {}}, "schema": []}
{"input": "Penicillin acylase (PA) from Escherichia coli ATCC11105 is a periplasmic heterodimer consisting of a 24 kDa small subunit and a 65 kDa large subunit.", "output": {"entities": {"gene": [{"text": "Penicillin acylase", "start": 0, "end": 18}, {"text": "PA", "start": 20, "end": 22}]}}, "schema": []}
{"input": "A murine expressed sequence tag (EST) showing homology with erythropoietin receptor (EPOR) was identified in the EST database.", "output": {"entities": {"gene": [{"text": "erythropoietin receptor", "start": 60, "end": 83}, {"text": "EPOR", "start": 85, "end": 89}]}}, "schema": []}
{"input": "When the LCx was partially occluded, mild PM-induced tachycardia resulted in decreased AoP (P = 0. 045) as well as in decreased SV (P = 0. 048); the LVEDP remained high (P = 0. 002).", "output": {"entities": {}}, "schema": []}
{"input": "Activation of nuclear factor (NF)-kappaB and subsequent proinflammatory gene expression in human airway epithelial cells can be evoked by oxidative stress.", "output": {"entities": {"gene": [{"text": "nuclear factor (NF)-kappaB", "start": 14, "end": 40}]}}, "schema": []}
{"input": "GAP JUNCTIONS IN THE BRAIN: PREFACE.", "output": {"entities": {}}, "schema": []}
{"input": "We have isolated and functionally characterized the mouse gene for the C2 subunit of the 20S proteasome.", "output": {"entities": {"gene": [{"text": "20S proteasome", "start": 89, "end": 103}]}}, "schema": []}
{"input": "Furthermore, as in the human gene, the 3' end of the Cacna1f gene maps within 5 kb of the 5' end of the mouse synaptophysin gene in a region orthologous to Xp11. 23.", "output": {"entities": {"gene": [{"text": "Cacna1f gene", "start": 53, "end": 65}, {"text": "mouse synaptophysin gene", "start": 104, "end": 128}]}}, "schema": []}
{"input": "With the human Rhotekin cDNA as a probe, Northern hybridization revealed that a 4. 0-kb transcript was expressed at a high level in prostate and at a middle level in 13 of 16 tissues examined, but it cannot be detected in liver and lung tissues.", "output": {"entities": {"gene": [{"text": "human Rhotekin cDNA", "start": 9, "end": 28}]}}, "schema": []}
{"input": "Similarly, co-expression of a dominant-negative mutant of p38alpha, but not of ERK1, ERK2, JNK1, or JNK2, reduces basal and cadmium-induced pE1-luc activity.", "output": {"entities": {"gene": [{"text": "p38alpha", "start": 58, "end": 66}, {"text": "ERK1", "start": 79, "end": 83}, {"text": "ERK2", "start": 85, "end": 89}, {"text": "JNK1", "start": 91, "end": 95}, {"text": "JNK2", "start": 100, "end": 104}, {"text": "pE1-luc", "start": 140, "end": 147}]}}, "schema": []}
{"input": "BACKGROUND: Gamma knife radiosurgery (GKR) is a safe and effective alternative to surgery for intracranial lesions.", "output": {"entities": {}}, "schema": []}
{"input": "It is mainly transcribed in neural structures and in developing organs characterized by epithelial-mesenchymal interactions.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSION: The alpha2-adrenergic antagonist idazoxan increases glucose-induced sympathetic activity but not energy expenditure in obese subjects.", "output": {"entities": {}}, "schema": []}
{"input": "Next, we show that two EMS-induced mutations, previously shown to interact genetically with zipper (Ebr), disrupt the RhoA locus.", "output": {"entities": {"gene": [{"text": "Ebr", "start": 100, "end": 103}, {"text": "RhoA locus", "start": 118, "end": 128}]}}, "schema": []}
{"input": "Therefore, the results indicate that repeated exposure to amphetamine or apomorphine overcomes the context-dependent component of sensitization of amphetamine-or apomorphine-induced stereotyped behavior.", "output": {"entities": {}}, "schema": []}
{"input": "Testing for serum IgM binding to GM1 ganglioside in clinical practice.", "output": {"entities": {"gene": [{"text": "serum IgM", "start": 12, "end": 21}]}}, "schema": []}
{"input": "Objective responses also occurred in studies that explored sequential use of exemestane after failure of aminoglutethimide (26% with exemestane 200 mg/day) or other nonsteroidal aromatase inhibitors (6. 6% with exemestane 25 mg/day).", "output": {"entities": {"gene": [{"text": "aromatase", "start": 178, "end": 187}]}}, "schema": []}
{"input": "The science of tissue engineering.", "output": {"entities": {}}, "schema": []}
{"input": "Endonuclease III (Nth) of Escherichia coli is a DNA glycosylase essential for the removal of oxidised pyrimidine base residues from DNA.", "output": {"entities": {"gene": [{"text": "Endonuclease III", "start": 0, "end": 16}, {"text": "Nth", "start": 18, "end": 21}, {"text": "DNA glycosylase", "start": 48, "end": 63}]}}, "schema": []}
{"input": "The duration of reactive hyperemia decreased with aging, but the difference between males and females was not significant at any age.", "output": {"entities": {}}, "schema": []}
{"input": "Acquired bile duct blockage: entry of hepatobiliary agent into an intrahepatic abscess.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, this study looks at the impact of synthesis conditions on block length and crystallinity, and the impact of the blocking on both, crystallinity and solubility of the polymers.", "output": {"entities": {}}, "schema": []}
{"input": "However, little was understood about the normal function of CREB-2 in mammalian development or organ physiology.", "output": {"entities": {"gene": [{"text": "CREB-2", "start": 60, "end": 66}]}}, "schema": []}
{"input": "Both the MVBF and the maximum EMG activity in the right masseter and the left anterior temporalis muscles were significantly decreased during muscle pain when the subjects bit on the painful side.", "output": {"entities": {}}, "schema": []}
{"input": "The total alkaloids contained in the peel of Atzimba, Lopez, Marciana, Montsama, Murca, and Puebla was lower than the limits recommended for food safety.", "output": {"entities": {}}, "schema": []}
{"input": "The detection success rate was determined for different markers using this MEK.", "output": {"entities": {"gene": [{"text": "MEK", "start": 75, "end": 78}]}}, "schema": []}
{"input": "Herein, we show that Smad3 physically interacts with the HMG box domain of LEF1 and that TGFbeta and Wnt pathways synergize to activate transcription of the Xenopus homeobox gene twin (Xtwn).", "output": {"entities": {"gene": [{"text": "Smad3", "start": 21, "end": 26}, {"text": "HMG", "start": 57, "end": 60}, {"text": "LEF1", "start": 75, "end": 79}, {"text": "TGFbeta", "start": 89, "end": 96}, {"text": "Wnt", "start": 101, "end": 104}, {"text": "twin", "start": 179, "end": 183}, {"text": "Xtwn", "start": 185, "end": 189}]}}, "schema": []}
{"input": "The transmembrane topology of Na (+)/H (+) exchanger NHE3 has been studied using in vitro transcription/translation of two types of fusion vectors designed to test membrane insertion properties of cDNA sequences encoding putative NHE3 membrane spanning domains (msds).", "output": {"entities": {"gene": [{"text": "NHE3", "start": 53, "end": 57}, {"text": "NHE3", "start": 230, "end": 234}]}}, "schema": []}
{"input": "Members of the titin/myosin light chain kinase family play an essential role in the organization of the actin/myosin cytoskeleton, especially in sarcomere assembly and function.", "output": {"entities": {"gene": [{"text": "titin", "start": 15, "end": 20}, {"text": "myosin light chain kinase", "start": 21, "end": 46}, {"text": "actin", "start": 104, "end": 109}, {"text": "myosin", "start": 110, "end": 116}]}}, "schema": []}
{"input": "Furthermore, a pTyr317 Shc phosphopeptide selectively recognized Grb2, Sos1, SHIP, and the p85 subunit of phosphatidylinositol 3' kinase from mast cells, as characterized by mass spectrometry.", "output": {"entities": {"gene": [{"text": "pTyr317 Shc phosphopeptide", "start": 15, "end": 41}, {"text": "Grb2", "start": 65, "end": 69}, {"text": "Sos1", "start": 71, "end": 75}, {"text": "SHIP", "start": 77, "end": 81}, {"text": "p85 subunit", "start": 91, "end": 102}, {"text": "phosphatidylinositol 3' kinase", "start": 106, "end": 136}]}}, "schema": []}
{"input": "Although increased expression of the HMG-I/Y proteins is associated with cellular proliferation, neoplastic transformation, and several human cancers, the role of these proteins in the pathogenesis of malignancy remains unclear.", "output": {"entities": {"gene": [{"text": "HMG-I/Y proteins", "start": 37, "end": 53}]}}, "schema": []}
{"input": "The naltrexone/lofexidine combination was associated with a more rapid resolution of the opiate withdrawal syndrome than a 7-day lofexidine-only treatment schedule, without substantial increases in withdrawal symptoms or hypotensive side-effects.", "output": {"entities": {}}, "schema": []}
{"input": "The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control.", "output": {"entities": {}}, "schema": []}
{"input": "PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1).", "output": {"entities": {"gene": [{"text": "PNRC", "start": 0, "end": 4}, {"text": "SF1", "start": 158, "end": 161}, {"text": "steroidogenic factor 1", "start": 163, "end": 185}, {"text": "ERRalpha1", "start": 191, "end": 200}, {"text": "estrogen related receptor alpha-1", "start": 202, "end": 235}]}}, "schema": []}
{"input": "Studies using a reporter plasmid with a functionally disrupted sterol-responsive element (SRE)-1 revealed a reduced stimulatory response to IL-6.", "output": {"entities": {"gene": [{"text": "IL-6", "start": 140, "end": 144}]}}, "schema": []}
{"input": "However, there is still a subset of tumors that displayed no changes in these genes.", "output": {"entities": {}}, "schema": []}
{"input": "Bailey Instruments and Owen Mumford filaments were the most accurate with 100% buckling within +/-1. 0 g of 10 g.", "output": {"entities": {}}, "schema": []}
{"input": "PARTICIPANTS: Convenience sample of ambulatory outpatients with hereditary motor and sensory neuropathy, type I (n = 9), myotonic muscular dystrophy (n = 10), and able-bodied controls (n = 11).", "output": {"entities": {}}, "schema": []}
{"input": "The effect of water deprivation for 19 h on renal Na excretion of conscious adrenalectomized (ADX) sheep maintained on a constant intravenous infusion of aldosterone and cortisol (ADX-constant steroid sheep) was investigated.", "output": {"entities": {}}, "schema": []}
{"input": "Neither is it a major cause of rehydration-induced renal Na retention.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSION: Rheumatic fever in the Nazareth area is still manifest.", "output": {"entities": {}}, "schema": []}
{"input": "Antithrombin III deficiency: when substitute, when heparin? Thrombosis ABC, 3: The role of antithrombin III", "output": {"entities": {"gene": [{"text": "Antithrombin III", "start": 0, "end": 16}]}}, "schema": []}
{"input": "Specific class I and II histone deacetylases (HDACs) interact in vivo with BCoR, suggesting that BCoR may functionally link these two classes of HDACs.", "output": {"entities": {"gene": [{"text": "class I and II histone deacetylases", "start": 9, "end": 44}, {"text": "HDACs", "start": 46, "end": 51}, {"text": "BCoR", "start": 75, "end": 79}, {"text": "BCoR", "start": 97, "end": 101}, {"text": "HDACs", "start": 145, "end": 150}]}}, "schema": []}
{"input": "This is the first example of a eukaryotic transcription factor complex containing both a MADS-box and a forkhead protein, and it has important implications for the regulation of mammalian gene expression.", "output": {"entities": {"gene": [{"text": "MADS-box", "start": 89, "end": 97}, {"text": "forkhead protein", "start": 104, "end": 120}]}}, "schema": []}
{"input": "After screening the Berkeley Drosophila Genome Project database with sequences from a recently characterized Leu-rich repeats-containing G protein-coupled receptor (LGR) from Drosophila (DLGR-1), we identified a second gene for a different LGR (DLGR-2) and cloned its cDNA.", "output": {"entities": {"gene": [{"text": "Leu-rich repeats-containing G protein-coupled receptor", "start": 109, "end": 163}, {"text": "LGR", "start": 165, "end": 168}, {"text": "DLGR-1", "start": 187, "end": 193}, {"text": "LGR", "start": 240, "end": 243}, {"text": "DLGR-2", "start": 245, "end": 251}]}}, "schema": []}
{"input": "Degenerate primers homologous to highly conserved regions of known CYP3A sequences were used for initial RT-PCRs.", "output": {"entities": {"gene": [{"text": "CYP3A sequences", "start": 67, "end": 82}]}}, "schema": []}
{"input": "When cells were microinjected with TFOs designed to bind to a 30-bp polypurine site situated between the two TK genes, recombination was observed at frequencies in the range of 1%, 2, 500-fold above the background.", "output": {"entities": {"gene": [{"text": "TK genes", "start": 109, "end": 117}]}}, "schema": []}
{"input": "Methyllevamisole was used as the internal standard.", "output": {"entities": {}}, "schema": []}
{"input": "Only transcripts specific for TSGF-2 are detected in ovary and testes tissues of adults as well as in puparia, while neither gene is expressed during the larval developmental stages.", "output": {"entities": {"gene": [{"text": "TSGF-2", "start": 30, "end": 36}]}}, "schema": []}
{"input": "In a gel retardation assay using HepG2 nuclear extracts, the 5' flanking sequence from-74 to-46 showed a shifted band.", "output": {"entities": {}}, "schema": []}
{"input": "Coimmunoprecipitation experiments performed in transfected cells showed that BCMA associates with TNFR-associated factor (TRAF) 1, TRAF2, and TRAF3 adaptor proteins.", "output": {"entities": {"gene": [{"text": "BCMA", "start": 77, "end": 81}, {"text": "TNFR-associated factor (TRAF) 1", "start": 98, "end": 129}, {"text": "TRAF2", "start": 131, "end": 136}, {"text": "TRAF3 adaptor proteins", "start": 142, "end": 164}]}}, "schema": []}
{"input": "Since the RINX gene is likely an ortholog of the goldfish Vsx1 gene, it has been named VSX1 by the Human Gene Nomenclature Committee.", "output": {"entities": {"gene": [{"text": "RINX gene", "start": 10, "end": 19}, {"text": "goldfish Vsx1 gene", "start": 49, "end": 67}, {"text": "VSX1", "start": 87, "end": 91}]}}, "schema": []}
{"input": "The chromosomal localization on distal chromosome 7 places it in a cluster of imprinted genes, flanked by the previously described Tapa1 and Kcnq1 genes.", "output": {"entities": {"gene": [{"text": "Tapa1", "start": 131, "end": 136}, {"text": "Kcnq1 genes", "start": 141, "end": 152}]}}, "schema": []}
{"input": "The present study was designed to evaluate the sensitivity and specificity of AMP CT (Gen-Probe Incorporated, San Diego, CA, USA) on urogenital specimens taken from symptomatic patients and on first void urine (FVU) specimens from asymptomatic patients.", "output": {"entities": {}}, "schema": []}
{"input": "The linear plasmid pCLU1 from the yeast Kluyveromyces lactis normally replicates in the cytoplasm, with the aid of the helper linear plasmid pGKL2, using terminal protein (TP) as a primer.", "output": {"entities": {"gene": [{"text": "terminal protein", "start": 154, "end": 170}, {"text": "TP", "start": 172, "end": 174}]}}, "schema": []}
{"input": "The repetitive ETn (early transposon) family of sequences represents an active \" mobile mutagen \" in the mouse genome.", "output": {"entities": {"gene": [{"text": "ETn", "start": 15, "end": 18}, {"text": "early transposon", "start": 20, "end": 36}]}}, "schema": []}
{"input": "The two main experimental variables were the attended hemifield (left or right) and the proportion of trials requiring a shift within that hemifield (20% or 80%).", "output": {"entities": {}}, "schema": []}
{"input": "The measurement of NO in biological systems using chemiluminescence.", "output": {"entities": {}}, "schema": []}
{"input": "Biochemical examinations of calcium-phosphorus metabolism included ions and PTH concentrations in blood serum, and the activity of bone isoenzyme of AP.", "output": {"entities": {"gene": [{"text": "PTH", "start": 76, "end": 79}, {"text": "AP", "start": 149, "end": 151}]}}, "schema": []}
{"input": "Atorvastatin was the most cost-effective HMG-CoA reductase inhibitor.", "output": {"entities": {"gene": [{"text": "HMG-CoA reductase", "start": 41, "end": 58}]}}, "schema": []}
{"input": "Pharmacoeconomic assessment of HMG-CoA reductase inhibitor therapy: an analysis based on the CURVES study.", "output": {"entities": {"gene": [{"text": "HMG-CoA reductase", "start": 31, "end": 48}]}}, "schema": []}
{"input": "Interestingly, although E domains of these two receptors are much less conserved, replacement of this domain in rtER by its human counterpart resulted in higher estradiol sensitivity but no increase in the magnitude of transactivation.", "output": {"entities": {"gene": [{"text": "rtER", "start": 112, "end": 116}]}}, "schema": []}
{"input": "G-DNA is a four-stranded DNA structure with diverse putative biological roles.", "output": {"entities": {}}, "schema": []}
{"input": "The effectiveness of NRT appears to be largely independent of the intensity of additional support provided to the smoker.", "output": {"entities": {}}, "schema": []}
{"input": "8% (95% CI, 21. 3-44. 3%).", "output": {"entities": {}}, "schema": []}
{"input": "In contrast, the action of GLP-1 at the CRE was not blocked by cotransfection with M1-CREB, an isoform that lacks a consensus serine residue serving as substrate for PKA-mediated phosphorylation.", "output": {"entities": {"gene": [{"text": "GLP-1", "start": 27, "end": 32}, {"text": "M1-CREB", "start": 83, "end": 90}, {"text": "PKA", "start": 166, "end": 169}]}}, "schema": []}
{"input": "Because all PDGFbetaR fusions described thus far result in splicing to a common exon of this gene, we performed 5'-rapid amplification of cDNA ends PCR on patient RNA.", "output": {"entities": {"gene": [{"text": "PDGFbetaR fusions", "start": 12, "end": 29}]}}, "schema": []}
{"input": "CONCLUSIONS: In essential hypertension an acute protein load induces a decrease in GFR that may normalize under antihypertensive treatment.", "output": {"entities": {}}, "schema": []}
{"input": "This finding suggested that the PI3K-Akt activation pathway plays some role in the antiapoptotic effect of EPO.", "output": {"entities": {"gene": [{"text": "PI3K", "start": 32, "end": 36}, {"text": "Akt", "start": 37, "end": 40}, {"text": "EPO", "start": 107, "end": 110}]}}, "schema": []}
{"input": "Nine DNA fragments that were specifically recognized and bound by histidine-tagged AdpA were isolated by cycles of a gel mobility shift-PCR method.", "output": {"entities": {"gene": [{"text": "AdpA", "start": 83, "end": 87}]}}, "schema": []}
{"input": "To determine whether the NTP-binding motif is important for Rad24 function, we mutated the conserved lysine (115) residue in this motif.", "output": {"entities": {"gene": [{"text": "Rad24", "start": 60, "end": 65}]}}, "schema": []}
{"input": "The carboxyl-terminal proline-rich domain of SOS1 is involved in the interaction with the PLC-gamma1 SH3 domain.", "output": {"entities": {"gene": [{"text": "SOS1", "start": 45, "end": 49}, {"text": "PLC-gamma1 SH3 domain", "start": 90, "end": 111}]}}, "schema": []}
{"input": "From transient expression studies, we could demonstrate that the SH3 domain of PLC-gamma1 is necessary for the association with SOS1 in vivo.", "output": {"entities": {"gene": [{"text": "SH3 domain", "start": 65, "end": 75}, {"text": "PLC-gamma1", "start": 79, "end": 89}, {"text": "SOS1", "start": 128, "end": 132}]}}, "schema": []}
{"input": "Wnt-1 overexpression in mammary epithelial cells induced cyclin D1 mRNA and targeted overexpression of Wnt-1 in the mammary gland of transgenic mice increased both ILK activity and cyclin D1 levels.", "output": {"entities": {"gene": [{"text": "Wnt-1", "start": 0, "end": 5}, {"text": "cyclin D1 mRNA", "start": 57, "end": 71}, {"text": "Wnt-1", "start": 103, "end": 108}, {"text": "ILK", "start": 164, "end": 167}, {"text": "cyclin D1", "start": 181, "end": 190}]}}, "schema": []}
{"input": "Intravenous versus oral administration of amitriptyline in patients with major depression.", "output": {"entities": {}}, "schema": []}
{"input": "Deletion of the RVH domain resulted in loss of Ca (2 +)-dependent activation.", "output": {"entities": {"gene": [{"text": "RVH domain", "start": 16, "end": 26}]}}, "schema": []}
{"input": "Logistic regression analysis revealed that physicians were 3. 6 times more likely to detect thin lesions (</= 0. 75 mm) compared with nonphysician detectors (95% confidence interval [95% CI], 2. 1, 6. 5; P = 0. 0001).", "output": {"entities": {}}, "schema": []}
{"input": "Erythema exsudativum multiforme induced by granulocyte colony-stimulating factor in an allogeneic peripheral blood stem cell donor.", "output": {"entities": {"gene": [{"text": "granulocyte colony-stimulating factor", "start": 43, "end": 80}]}}, "schema": []}
{"input": "VaI and VaII co-immunoprecipitated with ErbB2, but not with ErbB1, ErbB3, or ErbB4.", "output": {"entities": {"gene": [{"text": "ErbB2", "start": 40, "end": 45}, {"text": "ErbB1", "start": 60, "end": 65}, {"text": "ErbB3", "start": 67, "end": 72}, {"text": "ErbB4", "start": 77, "end": 82}]}}, "schema": []}
{"input": "While interactions of WT and variant TGF-alpha with the ErbBs all result in ErbB2 activation, they produce different biological consequences, suggesting that the various TGF-alpha precursors differentially modulate ErbB signaling.", "output": {"entities": {"gene": [{"text": "TGF-alpha", "start": 37, "end": 46}, {"text": "ErbBs", "start": 56, "end": 61}, {"text": "ErbB2", "start": 76, "end": 81}, {"text": "TGF-alpha precursors", "start": 170, "end": 190}, {"text": "ErbB", "start": 215, "end": 219}]}}, "schema": []}
{"input": "In contrast to full-length E2F-3, which is expressed only at the G1/S boundary, E2F-3B is detected throughout the cell cycle with peak levels in GO where it is associated with Rb.", "output": {"entities": {"gene": [{"text": "full-length E2F-3", "start": 15, "end": 32}, {"text": "E2F-3B", "start": 80, "end": 86}, {"text": "Rb", "start": 176, "end": 178}]}}, "schema": []}
{"input": "Developmental toxicity of the class III antiarrhythmic agent almokalant in mice.", "output": {"entities": {}}, "schema": []}
{"input": "In addition to its effect in augmenting the neutrophil response to eccentric exercise, vitamin E causes a greater increase in circulating creatine kinase activity, perhaps indicating increased skeletal muscle repair.", "output": {"entities": {"gene": [{"text": "creatine kinase", "start": 138, "end": 153}]}}, "schema": []}
{"input": "CONCLUSION: The authors emphasize that the initial management of primary STS should be adequate and suggest that safty margin of > or = 2 cm should be adhered to.", "output": {"entities": {}}, "schema": []}
{"input": "Measurements were compared with two computerised treatment planning systems--Theraplan VO5B and ADAC Pinnacle3 V4. 0b.", "output": {"entities": {}}, "schema": []}
{"input": "Activation was biphasic; peaking at 5-10 min and 24 h after treatment.", "output": {"entities": {}}, "schema": []}
{"input": "Whereas MARTA1 is clearly detectable in crude lysates, cytosolic and ribosomal salt-wash fractions, and in nuclear extracts, MARTA2 is preferentially found in the ribosomal salt-wash preparation.", "output": {"entities": {"gene": [{"text": "MARTA1", "start": 8, "end": 14}, {"text": "MARTA2", "start": 125, "end": 131}]}}, "schema": []}
{"input": "Five of the PDP1 isoforms differ by the substitution or insertion of amino acids at or near the N-terminal of the protein.", "output": {"entities": {"gene": [{"text": "PDP1 isoforms", "start": 12, "end": 25}]}}, "schema": []}
{"input": "The optimum technique for the pathological examination of sentinel lymph nodes (SLNs) is still under debate.", "output": {"entities": {}}, "schema": []}
{"input": "Partial correction of anemia with recombinant human erythropoietin likely reduces left ventricular mass and volume.", "output": {"entities": {"gene": [{"text": "recombinant human erythropoietin", "start": 34, "end": 66}]}}, "schema": []}
{"input": "This study demonstrated that the PFA-100 analyzer can accurately assess vWF-dependent platelet function and detect other platelet defects under high shear stress in complex patient populations.", "output": {"entities": {"gene": [{"text": "vWF", "start": 72, "end": 75}]}}, "schema": []}
{"input": "We recently reported the molecular cloning of a PL scramblase of human (HuPLSCR1) and mouse origin, respectively.", "output": {"entities": {"gene": [{"text": "PL scramblase", "start": 48, "end": 61}, {"text": "HuPLSCR1", "start": 72, "end": 80}]}}, "schema": []}
{"input": "To analyze the regulatory activity of Gtx, we first identified the optimal Gtx-binding sequence using an in vitro DNA-binding assay.", "output": {"entities": {"gene": [{"text": "Gtx", "start": 38, "end": 41}, {"text": "Gtx-binding sequence", "start": 75, "end": 95}]}}, "schema": []}
{"input": "Using an oligomer duplex 5'-A (GGGTTA) (5)-3'/5'-(TAACCC) (5) T-3' as a template-primer, we show that both the Klenow fragment of Escherichia coli DNA polymerase I and HIV reverse transcriptase could expand telomere DNA sequences as well, giving products greater than the size of the template DNA.", "output": {"entities": {"gene": [{"text": "Klenow fragment of Escherichia coli DNA polymerase I", "start": 111, "end": 163}, {"text": "HIV reverse transcriptase", "start": 168, "end": 193}]}}, "schema": []}
{"input": "Cdk2 and MAPK precipitates from untreated tumor lysates phosphorylated recombinant wild-type p27 but not the T187A mutant in vitro.", "output": {"entities": {"gene": [{"text": "Cdk2", "start": 0, "end": 4}, {"text": "MAPK", "start": 9, "end": 13}, {"text": "recombinant wild-type p27", "start": 71, "end": 96}]}}, "schema": []}
{"input": "The loss of avirulence activity because of mutations in the acidic transcriptional activation domain was restored by addition of the activation domain from the herpes simplex viral protein VP16.", "output": {"entities": {"gene": [{"text": "herpes simplex viral protein VP16", "start": 160, "end": 193}]}}, "schema": []}
{"input": "Mutations in the RP2 locus at Xp11. 3 were found in a further 10-20% of XLRP patients, as predicted from linkage studies.", "output": {"entities": {"gene": [{"text": "RP2 locus at Xp11. 3", "start": 17, "end": 37}]}}, "schema": []}
{"input": "Subsequently, HD inhibited healing because it significantly delayed epithelialization and caused protracted inflammation.", "output": {"entities": {}}, "schema": []}
{"input": "The effectiveness of the haemodialysate Solcoseryl for second-intention wound healing in horses and ponies.", "output": {"entities": {}}, "schema": []}
{"input": "Although there is little evidence that diet composition plays a clinically important role in the absorption or expenditure of energy, it does appear to play a role in food intake.", "output": {"entities": {}}, "schema": []}
{"input": "These findings were reinforced by an analysis that was restricted to living donor transplants without acute rejection.", "output": {"entities": {}}, "schema": []}
{"input": "The genome of the human herpesvirus 8 (HHV-8) contains a cluster of open reading frames (ORFs) encoding proteins with homology to the cellular transcription factors of the interferon regulatory factor (IRF) family.", "output": {"entities": {"gene": [{"text": "interferon regulatory factor", "start": 172, "end": 200}, {"text": "IRF", "start": 202, "end": 205}]}}, "schema": []}
{"input": "Despite these limitations the CHIME monitor provides an opportunity to record physiological data previously unavailable in the home.", "output": {"entities": {}}, "schema": []}
{"input": "DATA SYNTHESIS: Intracoronary ultrasound has been shown to improve upon demonstrated weaknesses of coronary angiography.", "output": {"entities": {}}, "schema": []}
{"input": "TB bone area (p < 0. 001), height (p < 0. 01), years in present colony (p = 0. 03), and menses (p < 0. 01) predicted TB BMC.", "output": {"entities": {}}, "schema": []}
{"input": "CREST syndrome; a changing clinical significance", "output": {"entities": {}}, "schema": []}
{"input": "Troglitazone also induced an endogenous PPARgamma target gene in T24 cells, adipocyte-type fatty acid binding protein (A-FABP), the expression of which correlates with bladder cancer differentiation.", "output": {"entities": {"gene": [{"text": "endogenous PPARgamma target gene", "start": 29, "end": 61}, {"text": "adipocyte-type fatty acid binding protein", "start": 76, "end": 117}, {"text": "A-FABP", "start": 119, "end": 125}]}}, "schema": []}
{"input": "The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.", "output": {"entities": {"gene": [{"text": "RS447 human megasatellite tandem repetitive sequence", "start": 4, "end": 56}]}}, "schema": []}
{"input": "Previous experience and contextual cues are essential elements in the generation of a subjective prediction.", "output": {"entities": {}}, "schema": []}
{"input": "To characterize this effect, we looked for targets of NS1 influenza virus protein among cellular translation factors.", "output": {"entities": {"gene": [{"text": "NS1 influenza virus protein", "start": 54, "end": 81}]}}, "schema": []}
{"input": "Collectively, these and previously published data suggest a model where NS1 recruits eIF4GI specifically to the 5' untranslated region (5' UTR) of the viral mRNA, allowing for the preferential translation of the influenza virus messengers.", "output": {"entities": {"gene": [{"text": "NS1", "start": 72, "end": 75}, {"text": "eIF4GI", "start": 85, "end": 91}]}}, "schema": []}
{"input": "Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus.", "output": {"entities": {"gene": [{"text": "Eukaryotic translation initiation factor 4GI", "start": 0, "end": 44}, {"text": "NS1 protein", "start": 70, "end": 81}]}}, "schema": []}
{"input": "(iii) In these cells, PKCbeta plays a unique Ras-independent role in mediating insulin but not EGF or other growth factor mitogenic signals.", "output": {"entities": {"gene": [{"text": "PKCbeta", "start": 22, "end": 29}, {"text": "Ras", "start": 45, "end": 48}, {"text": "insulin", "start": 79, "end": 86}, {"text": "EGF", "start": 95, "end": 98}]}}, "schema": []}
{"input": "However, it is not known whether the recently identified isoforms Vav2 and Vav3, which are broadly expressed, can couple with similar classes of receptors, nor is it known whether all Vav isoforms possess identical functional activities.", "output": {"entities": {"gene": [{"text": "Vav2", "start": 66, "end": 70}, {"text": "Vav3", "start": 75, "end": 79}, {"text": "Vav isoforms", "start": 184, "end": 196}]}}, "schema": []}
{"input": "Transcriptional regulation of fbp1 promoter constructs containing only UAS1 or UAS2 confirms that the PKA and MAPK regulation is targeted to both sites.", "output": {"entities": {"gene": [{"text": "fbp1 promoter constructs", "start": 30, "end": 54}, {"text": "PKA", "start": 102, "end": 105}, {"text": "MAPK", "start": 110, "end": 114}]}}, "schema": []}
{"input": "X-ray crystallographic data show that the PLZF BTB/POZ domain forms an obligate homodimer via an extensive interface.", "output": {"entities": {"gene": [{"text": "PLZF BTB", "start": 42, "end": 50}]}}, "schema": []}
{"input": "The ability of SMRT to associate with these transcription factors and thereby to mediate repression is strongly inhibited by activation of tyrosine kinase signaling pathways, such as that represented by the epidermal growth factor receptor.", "output": {"entities": {"gene": [{"text": "SMRT", "start": 15, "end": 19}, {"text": "tyrosine kinase", "start": 139, "end": 154}, {"text": "epidermal growth factor receptor", "start": 207, "end": 239}]}}, "schema": []}
{"input": "In addition, the ketamine-treated rats had more neurons and glial cells surrounding the ventricles.", "output": {"entities": {}}, "schema": []}
{"input": "The differences were as follows: for overall response rate p = 0. 004; power (for p = 0. 05) 85%; for survival p = 0. 09; for grade IV granulocytopenia p = 0. 3; and for febrile neutropenia p = 0. 61.", "output": {"entities": {}}, "schema": []}
{"input": "Patients were randomly assigned to treatment with the ACE inhibitor perindopril (and the diuretic indapamide for those with no definite indication for or contraindication to treatment with a diuretic) or matching placebo (s).", "output": {"entities": {"gene": [{"text": "ACE", "start": 54, "end": 57}]}}, "schema": []}
{"input": "The results indicate that the open-section effect decreases the torsional stiffness and stress concentration effects decrease the torsional strength of a long bone with a longitudinal defect.", "output": {"entities": {}}, "schema": []}
{"input": "These regions may be differentially involved in tissue-specificity, and/or circadian regulation, of the human hPer1 gene transcription.", "output": {"entities": {"gene": [{"text": "human hPer1 gene", "start": 104, "end": 120}]}}, "schema": []}
{"input": "Additionally, putative CF1/USP and Broad Complex Z2 transcription factor elements were found in the upstream regions of MIH and MO-IH genes respectively.", "output": {"entities": {"gene": [{"text": "CF1", "start": 23, "end": 26}, {"text": "USP", "start": 27, "end": 30}, {"text": "Broad Complex Z2", "start": 35, "end": 51}, {"text": "MIH", "start": 120, "end": 123}, {"text": "MO-IH", "start": 128, "end": 133}]}}, "schema": []}
{"input": "Sequence analysis reveals that the newly discovered oasA2 gene represents a pseudogene that is still transcribed, but is not functionally translated.", "output": {"entities": {"gene": [{"text": "oasA2 gene", "start": 52, "end": 62}]}}, "schema": []}
{"input": "Genomic and functional characterization of the oas gene family encoding O-acetylserine (thiol) lyases, enzymes catalyzing the final step in cysteine biosynthesis in Arabidopsis thaliana.", "output": {"entities": {"gene": [{"text": "oas gene family", "start": 47, "end": 62}, {"text": "O-acetylserine (thiol) lyases", "start": 72, "end": 101}]}}, "schema": []}
{"input": "Two distinct recessive susceptibility loci for vasculitis were mapped on chromosome (Chr) 4 at D4Mit89 and D4Mit147 in both progenies.", "output": {"entities": {"gene": [{"text": "D4Mit89", "start": 95, "end": 102}, {"text": "D4Mit147", "start": 107, "end": 115}]}}, "schema": []}
{"input": "Further characterization of these putative Hoxa-1 target genes will aid in delineating the functions of the Hoxa-1 protein in the differentiation processes which occur during embryogenesis.", "output": {"entities": {"gene": [{"text": "Hoxa-1 target genes", "start": 43, "end": 62}, {"text": "Hoxa-1 protein", "start": 108, "end": 122}]}}, "schema": []}
{"input": "The ability of U6-U57 mutants to influence the fidelity of both branch site and 3' splice site recognition suggests that this nucleotide may participate in the formation of the active site (s) of the spliceosome.", "output": {"entities": {"gene": [{"text": "U6", "start": 15, "end": 17}, {"text": "U57", "start": 18, "end": 21}]}}, "schema": []}
{"input": "We have determined the structure of the WNT-2B gene.", "output": {"entities": {"gene": [{"text": "WNT-2B gene", "start": 40, "end": 51}]}}, "schema": []}
{"input": "The role of daunorubicin in induction therapy for adult acute myeloid leukemia", "output": {"entities": {}}, "schema": []}
{"input": "TNF-alpha induced a dose-and time-dependent increase in cyclooxygenase-2 (COX-2) expression and PGE2 formation in human NCI-H292 epithelial cells.", "output": {"entities": {"gene": [{"text": "TNF-alpha", "start": 0, "end": 9}, {"text": "cyclooxygenase-2", "start": 56, "end": 72}, {"text": "COX-2", "start": 74, "end": 79}]}}, "schema": []}
{"input": "The therapy time to deliver the NCS therapeutic dose of 10000 RBE-cGy, is 27 times longer when 157Gd is used instead of 10B.", "output": {"entities": {}}, "schema": []}
{"input": "Mis3 is needed for the formation of 18S ribosome RNA, and may hence direct the level of proteins required for the coupling.", "output": {"entities": {"gene": [{"text": "Mis3", "start": 0, "end": 4}, {"text": "18S ribosome RNA", "start": 36, "end": 52}]}}, "schema": []}
{"input": "Losartan Intervention For Endpoint.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSION: Vitrectomy for vitreous hemorrhage in Terson syndrome is a safe and effective procedure, offering a rapid and prolonged improvement in vision.", "output": {"entities": {}}, "schema": []}
{"input": "RNA in situ hybridization on brain sections of normal human embryos revealed a strong labeling in restricted areas of the cerebral cortex.", "output": {"entities": {}}, "schema": []}
{"input": "To facilitate manipulation of large genomic sequences, we developed a method of converting Escherichia coli P1 artificial chromosomes (PACs) into yeast artificial chromosomes (YACs).", "output": {"entities": {}}, "schema": []}
{"input": "After gamma-irradiation, the majority of F9 cells undergo apoptosis implying that wt-p53 likely triggers pro-apoptotic gene expression in DNA damaged cells.", "output": {"entities": {"gene": [{"text": "wt-p53", "start": 82, "end": 88}]}}, "schema": []}
{"input": "Mobilization with cyclophosphamide and granulocyte-colony stimulating factor was effective in terms of CD34 + cell shift to peripheral blood and the good quality autograft reliably led to haematopoetic recovery after megachemotherapy.", "output": {"entities": {"gene": [{"text": "granulocyte-colony stimulating factor", "start": 39, "end": 76}, {"text": "CD34 +", "start": 103, "end": 109}]}}, "schema": []}
{"input": "This suggests that cardiovascular magnetic resonance is the preferred technique for volume and ejection fraction estimation in heart failure patients, because of its 3D approach for non-symmetric ventricles and superior image quality.", "output": {"entities": {}}, "schema": []}
{"input": "A degenerate DNA transposon, Pat, was identified in the genomes of various wild-type strains of the filamentous fungus Podospora anserina.", "output": {"entities": {"gene": [{"text": "Pat", "start": 29, "end": 32}]}}, "schema": []}
{"input": "However, the presence of Tax I increased the extent and altered the profile of proteins binding TRE-2 in vivo.", "output": {"entities": {"gene": [{"text": "Tax I", "start": 25, "end": 30}, {"text": "TRE-2", "start": 96, "end": 101}]}}, "schema": []}
{"input": "We have also identified a functional domain in the ORF 50 protein, an immediate-early gene product that is mainly encoded by ORF 50.", "output": {"entities": {"gene": [{"text": "immediate-early gene product", "start": 70, "end": 98}]}}, "schema": []}
{"input": "A 2. 3-kb full-length cDNA clone of an Atlantic halibut Mx gene was isolated from a liver cDNA library.", "output": {"entities": {"gene": [{"text": "Atlantic halibut Mx gene", "start": 39, "end": 63}]}}, "schema": []}
{"input": "PLUS-3 is a new Swedish protocol of natural speech in 3-year-old children.", "output": {"entities": {}}, "schema": []}
{"input": "Once HIT II is suspected, heparin (and low-molecular-weight heparins) should be stopped immediately.", "output": {"entities": {}}, "schema": []}
{"input": "The reduced efficiency in the glycosylase activity is also reflected in a reduced ability of S120K MutY to prevent DNA mutations in vivo.", "output": {"entities": {"gene": [{"text": "glycosylase", "start": 30, "end": 41}, {"text": "S120K MutY", "start": 93, "end": 103}]}}, "schema": []}
{"input": "METHODS AND RESULTS: We prospectively compared the automated measurements of left ventricular ejection fraction (LVEF) and volumes from rest-injected gated Technetium 99m (Tc99m) perfusion SPECT with equilibrium radionuclide angiocardiography (ERNA) in 62 patients and the assessment of regional function with echocardiography in 22 patients.", "output": {"entities": {}}, "schema": []}
{"input": "This intracellular signaling, known as the unfolded protein response (UPR), is mediated by the cis-acting ER stress response element (ERSE) in mammals.", "output": {"entities": {}}, "schema": []}
{"input": "A Y. lipolytica Kar2p mutant was isolated that restored interaction with an Sls1p mutant, suggesting that the interaction with Sls1p could be nucleotide and/or conformation dependent.", "output": {"entities": {"gene": [{"text": "Y. lipolytica Kar2p mutant", "start": 2, "end": 28}, {"text": "Sls1p mutant", "start": 76, "end": 88}, {"text": "Sls1p", "start": 127, "end": 132}]}}, "schema": []}
{"input": "We have carried out a comprehensive and systematic mutagenesis of the Cse4p N terminus to analyze its function.", "output": {"entities": {"gene": [{"text": "Cse4p N terminus", "start": 70, "end": 86}]}}, "schema": []}
{"input": "The spacing of the essential N-terminal domain (END) relative to the HFD can be changed significantly without an apparent effect on Cse4p function.", "output": {"entities": {"gene": [{"text": "HFD", "start": 69, "end": 72}, {"text": "Cse4p", "start": 132, "end": 137}]}}, "schema": []}
{"input": "The bases of this comparison are reviewed and discussed.", "output": {"entities": {}}, "schema": []}
{"input": "In invertebrates, Fhit is encoded as a fusion protein with Nit, a member of the nitrilase superfamily.", "output": {"entities": {"gene": [{"text": "Fhit", "start": 18, "end": 22}, {"text": "Nit", "start": 59, "end": 62}, {"text": "nitrilase superfamily", "start": 80, "end": 101}]}}, "schema": []}
{"input": "The manifestations often include a moderate thrombocytopenia and, less commonly, hemolysis.", "output": {"entities": {}}, "schema": []}
{"input": "A beta2 RARE reporter construct in which the methylation-susceptible cytosines in the sense strand were replaced by thymine displayed marked loss of activity in a replicated chromatin-dependent manner.", "output": {"entities": {"gene": [{"text": "beta2 RARE reporter construct", "start": 2, "end": 31}]}}, "schema": []}
{"input": "Non-poliomyelitis AFP rate had increased from 0. 9 in 1997 to 2. 8 in 1998.", "output": {"entities": {}}, "schema": []}
{"input": "Consciousness is connected with attention, working memory and perception.", "output": {"entities": {}}, "schema": []}
{"input": "Multiparity had a protective effect with 0. 66 less risk (95% CI 0. 44-0. 99).", "output": {"entities": {}}, "schema": []}
{"input": "Picture the smell.", "output": {"entities": {}}, "schema": []}
{"input": "Only two of 27 participants (7. 4%) with definite POAG had been previously diagnosed and treated, and 66. 7% of the previously undiagnosed had IOP less than 22 mmHg.", "output": {"entities": {}}, "schema": []}
{"input": "Taken together, they uphold the emerging concern that women with ER (+) cancers may not benefit significantly from endocrine treatment if the tumors also overexpress HER-2.", "output": {"entities": {"gene": [{"text": "ER (+)", "start": 65, "end": 71}, {"text": "HER-2", "start": 166, "end": 171}]}}, "schema": []}
{"input": "Promoter activity was dose-dependently inhibited by cotransfection with either ras or mos oncogenes, but oncogene inhibition was reversed and the overall activity increased when cells were treated with the MAP kinase kinase (MKK) inhibitor PD98059.", "output": {"entities": {"gene": [{"text": "ras", "start": 79, "end": 82}, {"text": "mos oncogenes", "start": 86, "end": 99}, {"text": "MAP kinase kinase", "start": 206, "end": 223}, {"text": "MKK", "start": 225, "end": 228}]}}, "schema": []}
{"input": "Our results indicate that the expression of Cktsf1b1, a gene associated with early development and cell transformation, is sensitive to MKK levels and may be regulated via multiple transcription factor complexes.", "output": {"entities": {"gene": [{"text": "Cktsf1b1", "start": 44, "end": 52}, {"text": "MKK", "start": 136, "end": 139}]}}, "schema": []}
{"input": "INTERVENTIONS: Subcutaneous tissue PO2 and PCO2 tensions were measured directly in patients with necrotising fasciitis and in healthy volunteers during normobaric and hyperbaric conditions.", "output": {"entities": {}}, "schema": []}
{"input": "Because GH-induced Akt activation was completely inhibited in both cells by the same concentration of LY294002, these findings indicate that the wortmannin sensitivity of both the IRS-1-independent and-dependent GH-induced MAP kinase activation may reflect the activity of another wortmannin-sensitive target (s) in addition to PI3K in mediation of GH-induced MAP kinase activation in these cells.", "output": {"entities": {"gene": [{"text": "GH", "start": 8, "end": 10}, {"text": "Akt", "start": 19, "end": 22}, {"text": "IRS-1", "start": 180, "end": 185}, {"text": "GH", "start": 212, "end": 214}, {"text": "MAP kinase", "start": 223, "end": 233}, {"text": "PI3K", "start": 328, "end": 332}, {"text": "GH", "start": 349, "end": 351}, {"text": "MAP kinase", "start": 360, "end": 370}]}}, "schema": []}
{"input": "Insulin receptor substrate-1-mediated enhancement of growth hormone-induced mitogen-activated protein kinase activation.", "output": {"entities": {"gene": [{"text": "Insulin receptor substrate-1", "start": 0, "end": 28}, {"text": "growth hormone", "start": 53, "end": 67}, {"text": "mitogen-activated protein kinase", "start": 76, "end": 108}]}}, "schema": []}
{"input": "Functional magnetic resonance imaging (fMRI) has been increasingly used in studying human brain function given its non-invasive feature and good spatial resolution.", "output": {"entities": {}}, "schema": []}
{"input": "After declamping of the aorta, there were also severe edema, local fibre necrosis, and adhesion of leucocytes, whereas muscle fibre areas became 3, 935. 18 micro 531 microm (2) for type I and 5, 804 +/-1, 075 microm (2) for type II.", "output": {"entities": {}}, "schema": []}
{"input": "It was found that increase in the RH level boosts the current values by 2-3 orders of magnitude; contrariwise, the voltage values rise by about three times with drop in the RH.", "output": {"entities": {}}, "schema": []}
{"input": "Genomic libraries were stored as frozen cultures in a 96-well format, each well containing approximately 300-600 colonies (12 plates for small library, four for medium-size library and four for large library).", "output": {"entities": {}}, "schema": []}
{"input": "In several cell lines, mTOR or its downstream targets can be regulated by phosphatidylinositol (PI) 3-kinase; protein kinases A, B, and C; heterotrimeric G-proteins; a PD98059-sensitive kinase or calcium; as well as by amino acids.", "output": {"entities": {"gene": [{"text": "mTOR", "start": 23, "end": 27}, {"text": "phosphatidylinositol (PI) 3-kinase", "start": 74, "end": 108}, {"text": "protein kinases A, B, and C", "start": 110, "end": 137}, {"text": "heterotrimeric G-proteins", "start": 139, "end": 164}]}}, "schema": []}
{"input": "The importance of this new epidemiological profile of schistosomiasis in the State of Pernambuco relies on the fact that it can be related with the drastic human interference on the environment.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: No significant deformation in vertebral artery flow was noted in the flexion-distraction Stage I injuries within the physiologic range of cervical flexion.", "output": {"entities": {}}, "schema": []}
{"input": "We screened a K562 cDNA library and identified novel transcripts, MZF1B and MZF1C.", "output": {"entities": {"gene": [{"text": "MZF1B", "start": 66, "end": 71}, {"text": "MZF1C", "start": 76, "end": 81}]}}, "schema": []}
{"input": "The human cDNA clone NFBD1 (previously designated KIAA0170) encodes a novel protein (2089 amino acids in length; calculated molecular mass 226, 440 D) with possible BRCT domains at its carboxy terminus (amino acid residues 1894-2089).", "output": {"entities": {"gene": [{"text": "BRCT domains", "start": 165, "end": 177}]}}, "schema": []}
{"input": "RESULTS: Neither basal FSH level nor stimulated FSH level alone were statistically significant predictors of IVF success; however, no patient with a day 3 FSH level > 11. 1 mIU/ml or a stimulated day 10 FSH level > 13. 5 mIU/ml conceived and carried a pregnancy.", "output": {"entities": {"gene": [{"text": "FSH", "start": 23, "end": 26}, {"text": "FSH", "start": 48, "end": 51}, {"text": "FSH", "start": 155, "end": 158}, {"text": "FSH", "start": 203, "end": 206}]}}, "schema": []}
{"input": "Parathyroid hormone regulation of bone sialoprotein (BSP) gene transcription is mediated through a pituitary-specific transcription factor-1 (Pit-1) motif in the rat BSP gene promoter.", "output": {"entities": {"gene": [{"text": "Parathyroid hormone", "start": 0, "end": 19}, {"text": "bone sialoprotein", "start": 34, "end": 51}, {"text": "BSP", "start": 53, "end": 56}, {"text": "pituitary-specific transcription factor-1", "start": 99, "end": 140}, {"text": "Pit-1", "start": 142, "end": 147}, {"text": "rat BSP gene promoter", "start": 162, "end": 183}]}}, "schema": []}
{"input": "Recent target BP goals promulgated by the Sixth Report from the Joint National Committee (JNC VI) are based on the premise that the intensity of treatment directly corresponds to the magnitude of pretreatment risk.", "output": {"entities": {}}, "schema": []}
{"input": "Linking continuous community-based morbidity recording of influenza-like illness (ILI) with virological sampling has consistently proved its value as one of the earliest indicators of circulating influenza activity.", "output": {"entities": {}}, "schema": []}
{"input": "These include NPF repeats, a leucine heptad repeat enriched in charged residues, and a proline-rich SH3-like and/or WW domain-binding site in the N-terminal domain, which is followed by a membrane core containing four putative transmembrane spans and three amphiphilic segments that are the most highly conserved structural elements.", "output": {"entities": {"gene": [{"text": "SH3-like", "start": 100, "end": 108}]}}, "schema": []}
{"input": "We show here that this difference is due to the presence of a Mot3 binding site in OpA.", "output": {"entities": {"gene": [{"text": "Mot3 binding site", "start": 62, "end": 79}, {"text": "OpA", "start": 83, "end": 86}]}}, "schema": []}
{"input": "The article deals with the diagnosing and correction of reversible ischemia of the intestine.", "output": {"entities": {}}, "schema": []}
{"input": "Functional recognition of 5' splice site by U4/U6. U5 tri-snRNP defines a novel ATP-dependent step in early spliceosome assembly.", "output": {"entities": {"gene": [{"text": "U4", "start": 44, "end": 46}, {"text": "U6", "start": 47, "end": 49}, {"text": "U5", "start": 51, "end": 53}]}}, "schema": []}
{"input": "As control, the cells were transfected with DNA mixtures containing vector mU6-C1 or mU6-C2.", "output": {"entities": {}}, "schema": []}
{"input": "In this regard, we have recently observed that a constitutively active G protein-coupled receptor (GPCR) encoded by the Kaposi' s sarcoma-associated herpes virus (KSHV)/human herpes virus 8 is oncogenic and stimulates angiogenesis by increasing the secretion of vascular endothelial growth factor (VEGF), which is a key angiogenic stimulator and a critical mitogen for the development of Kaposi' s sarcoma.", "output": {"entities": {"gene": [{"text": "G protein-coupled receptor", "start": 71, "end": 97}, {"text": "GPCR", "start": 99, "end": 103}, {"text": "vascular endothelial growth factor", "start": 262, "end": 296}, {"text": "VEGF", "start": 298, "end": 302}]}}, "schema": []}
{"input": "No specific subgroup of clients benefited more from URD, although a prospective study employing random assignment might be more successful in identifying such a group.", "output": {"entities": {}}, "schema": []}
{"input": "In the lattice, 23% of the sites are occupied, 95% of the atoms are in the lowest energy magnetic sublevel, and 37% are in the lowest 3D vibrational state.", "output": {"entities": {}}, "schema": []}
{"input": "Coexisting vertical and horizontal one and a half syndromes.", "output": {"entities": {}}, "schema": []}
{"input": "As in the other three members whose gene expression is altered during tumorigenesis, PI12 expression was found to be down-regulated in tumor brain tissues and in two brain cancer cell lines: U-87 MG and H4.", "output": {"entities": {"gene": [{"text": "PI12", "start": 85, "end": 89}]}}, "schema": []}
{"input": "This slope was further significantly decreased at 5 min ischemia (-26. 5 +/-8. 8 microm/mmHg) but returned toward control values in short-term hibernating myocardium at 90 min ischemia (-17. 2 +/-6. 6 microm/mmHg).", "output": {"entities": {}}, "schema": []}
{"input": "Whereas both MAP and MSNA increase during SHG, the transition from SHG to PHI is characterized by a transient reduction in MAP but sustained elevation in MSNA, facilitating separation of these factors in vivo.", "output": {"entities": {}}, "schema": []}
{"input": "We have recently discovered that CCAAAT/enhancer-binding protein-beta (C/EBP-beta) induces gene transcription through a novel IFN response element called the gamma-IFN-activated transcriptional element", "output": {"entities": {"gene": [{"text": "CCAAAT/enhancer-binding protein-beta", "start": 33, "end": 69}, {"text": "C/EBP-beta", "start": 71, "end": 81}, {"text": "IFN response element", "start": 126, "end": 146}]}}, "schema": []}
{"input": "Northern blot analysis demonstrated that the STORP gene has a ubiquitous pattern of expression similar to that of the PML gene.", "output": {"entities": {"gene": [{"text": "STORP gene", "start": 45, "end": 55}, {"text": "PML gene", "start": 118, "end": 126}]}}, "schema": []}
{"input": "In the TLE patients the NAA: Cr ratios were reduced in the seizure focus, while in the FLE patients they were not always reduced in the seizure focus.", "output": {"entities": {}}, "schema": []}
{"input": "The psychologic factors associated wth serious illness, terminal prognoses, and dying complicate the scenario even more as compared with that of nonmalignant pain.", "output": {"entities": {}}, "schema": []}
{"input": "However, if the spatial resolution is not critical and interest is to compare a pathologic area with a contralateral VOI, then the acquisition of two single-voxel spectra may be preferred.", "output": {"entities": {}}, "schema": []}
{"input": "Quantitative evaluation of magneto-optical parameters is necessary in order to apply scanning near-field optical microscope (SNOM) technology to the study of magnetism on the mesoscopic scale.", "output": {"entities": {}}, "schema": []}
{"input": "We found that the amplitude of the cortical evoked potentials (amplitude of the N2/P2 peak) increased from 5. 1 +/-0. 7 microV at 5 mA to 16. 3 +/-1. 1 microV at 20 mA.", "output": {"entities": {}}, "schema": []}
{"input": "LMP-1 is targeted to the plasma membrane, where it binds TRAF, TRADD, and JAK molecules to activate NF-kappaB-, AP-1-, and STAT-dependent pathways as does CD40.", "output": {"entities": {"gene": [{"text": "LMP-1", "start": 0, "end": 5}, {"text": "TRAF", "start": 57, "end": 61}, {"text": "TRADD", "start": 63, "end": 68}, {"text": "JAK molecules", "start": 74, "end": 87}, {"text": "NF-kappaB", "start": 100, "end": 109}, {"text": "AP-1", "start": 112, "end": 116}, {"text": "STAT", "start": 123, "end": 127}, {"text": "CD40", "start": 155, "end": 159}]}}, "schema": []}
{"input": "Identification of an enhancer and an alternative promoter in the first intron of the alpha-fetoprotein gene.", "output": {"entities": {"gene": [{"text": "alpha-fetoprotein gene", "start": 85, "end": 107}]}}, "schema": []}
{"input": "Studying intracellular signaling pathways, which may be involved in malignant transformation of Ret-9bp expressing NIH3T3 cells, we could demonstrate Ret-9bp dependent phosphorylation of insulin receptor substrate-2 (IRS-2) with consecutive activation of phosphatidylinositol 3-kinase (PI 3-kinase) and protein kinase B (PKB/AKT).", "output": {"entities": {"gene": [{"text": "Ret-9bp", "start": 96, "end": 103}, {"text": "Ret-9bp", "start": 150, "end": 157}, {"text": "insulin receptor substrate-2", "start": 187, "end": 215}, {"text": "IRS-2", "start": 217, "end": 222}, {"text": "phosphatidylinositol 3-kinase", "start": 255, "end": 284}, {"text": "PI 3-kinase", "start": 286, "end": 297}, {"text": "protein kinase B", "start": 303, "end": 319}, {"text": "PKB", "start": 321, "end": 324}, {"text": "AKT", "start": 325, "end": 328}]}}, "schema": []}
{"input": "METHODS: In the current study the authors reported on PPB cases from a national retrospective search performed in 18 Italian Associations for Pediatric Hematology and Oncology centers.", "output": {"entities": {}}, "schema": []}
{"input": "Phylogenetic analysis showed that the ToLCV isolates from Bangalore constitute a group of viruses separated from those of Northern India.", "output": {"entities": {}}, "schema": []}
{"input": "Mutating the Fcp1p-binding motif KEFGK in the RAP74 (Tfg1p) subunit of TFIIF to EEFGE led to both synthetic phenotypes in certain fcp1 tfg1 double mutants and a reduced ability of Fcp1p to activate transcription when it is artificially tethered to a promoter.", "output": {"entities": {"gene": [{"text": "Fcp1p", "start": 13, "end": 18}, {"text": "RAP74", "start": 46, "end": 51}, {"text": "Tfg1p", "start": 53, "end": 58}, {"text": "TFIIF", "start": 71, "end": 76}, {"text": "fcp1 tfg1", "start": 130, "end": 139}, {"text": "Fcp1p", "start": 180, "end": 185}]}}, "schema": []}
{"input": "Deletion of an intergenic DNA-binding site for this complex from a human beta-globin locus construct results in delayed human gamma-to beta-globin switching in transgenic mice, suggesting that the PYR complex acts to facilitate the switch.", "output": {"entities": {"gene": [{"text": "human beta-globin locus construct", "start": 67, "end": 100}, {"text": "human gamma-to beta-globin", "start": 120, "end": 146}, {"text": "PYR complex", "start": 197, "end": 208}]}}, "schema": []}
{"input": "The product of rat gene 33 was identified as an ErbB-2-interacting protein in a two-hybrid screen employing the ErbB-2 juxtamembrane and kinase domains as bait.", "output": {"entities": {"gene": [{"text": "rat gene 33", "start": 15, "end": 26}, {"text": "ErbB-2-interacting protein", "start": 48, "end": 74}, {"text": "ErbB-2 juxtamembrane and kinase domains", "start": 112, "end": 151}]}}, "schema": []}
{"input": "Studies suggest that the DGOR without acid reflux may result in symptoms but unless acid reflux is present simultaneously, it does not cause oesophagitis.", "output": {"entities": {}}, "schema": []}
{"input": "OBJECTIVE: To evaluate the relationship between blood flow in the tumor assessed by color Doppler ultrasound, microvessel density, and vascular endothelial growth factor levels in endometrial carcinoma.", "output": {"entities": {"gene": [{"text": "vascular endothelial growth factor", "start": 135, "end": 169}]}}, "schema": []}
{"input": "These results demonstrate Ras-and Raf-independent ERK MAPK activation maintains cell viability following heat shock.", "output": {"entities": {"gene": [{"text": "Ras", "start": 26, "end": 29}, {"text": "Raf", "start": 34, "end": 37}, {"text": "ERK", "start": 50, "end": 53}]}}, "schema": []}
{"input": "Three cDNAs encoding basic leucine zipper (bZIP)-type ABRE-binding proteins were isolated by using the yeast one-hybrid system and were designated AREB1, AREB2, and AREB3 (ABA-responsive element binding protein).", "output": {"entities": {"gene": [{"text": "basic leucine zipper (bZIP)-type ABRE-binding proteins", "start": 21, "end": 75}, {"text": "AREB1", "start": 147, "end": 152}, {"text": "AREB2", "start": 154, "end": 159}, {"text": "AREB3", "start": 165, "end": 170}, {"text": "ABA-responsive element binding protein", "start": 172, "end": 210}]}}, "schema": []}
{"input": "Recombinant AROM-p64 displayed high binding to single-stranded DNA and poly (A) homopolymers suggesting that this protein could play a role in mRNA maturation/metabolism.", "output": {"entities": {"gene": [{"text": "AROM", "start": 12, "end": 16}, {"text": "p64", "start": 17, "end": 20}]}}, "schema": []}
{"input": "The protein-tyrosine kinase fer associates with signaling complexes containing insulin receptor substrate-1 and phosphatidylinositol 3-kinase.", "output": {"entities": {"gene": [{"text": "protein-tyrosine kinase fer", "start": 4, "end": 31}, {"text": "insulin receptor substrate-1", "start": 79, "end": 107}, {"text": "phosphatidylinositol 3-kinase", "start": 112, "end": 141}]}}, "schema": []}
{"input": "In the PMR target area but not in the nontreated area an improvement in regional myocardial flow reserve occurs in wall segments with initially severely or moderately reduced stress perfusion.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of intron/exon boundaries of the genomic BAC clones demonstrate that junctin, junctate, and aspartyl beta-hydroxylase result from alternative splicing of the same gene.", "output": {"entities": {"gene": [{"text": "junctin", "start": 78, "end": 85}, {"text": "junctate", "start": 87, "end": 95}, {"text": "aspartyl beta-hydroxylase", "start": 101, "end": 126}]}}, "schema": []}
{"input": "The growth factor receptor-bound protein 2 (Grb2) adaptor when complexed with Sos (Son of sevenless), the exchange factor of Ras, conveys the signal induced by tyrosine kinase-activated receptor to Ras by recruiting Sos to the membrane, allowing activation of Ras.", "output": {"entities": {"gene": [{"text": "growth factor receptor-bound protein 2", "start": 4, "end": 42}, {"text": "Grb2", "start": 44, "end": 48}, {"text": "Sos", "start": 78, "end": 81}, {"text": "Son of sevenless", "start": 83, "end": 99}, {"text": "Ras", "start": 125, "end": 128}, {"text": "tyrosine kinase-activated receptor", "start": 160, "end": 194}, {"text": "Ras", "start": 198, "end": 201}, {"text": "Sos", "start": 216, "end": 219}, {"text": "Ras", "start": 260, "end": 263}]}}, "schema": []}
{"input": "Mutations in genes encoding PR65/A subunits have been identified in several different human cancers and the PP2A inhibitor, termed fostriecin, is being tested as an anticancer drug.", "output": {"entities": {"gene": [{"text": "PR65/A subunits", "start": 28, "end": 43}, {"text": "PP2A", "start": 108, "end": 112}]}}, "schema": []}
{"input": "For this purpose, a segment of dxr was amplified from Synechococcus leopoliensis SAUG 1402-1 DNA via PCR using oligonucleotides for conserved regions.", "output": {"entities": {"gene": [{"text": "dxr", "start": 31, "end": 34}]}}, "schema": []}
{"input": "Perceptual learning for a pattern discrimination task.", "output": {"entities": {}}, "schema": []}
{"input": "While this Saccharomyces cerevisiae SIN4 gene product is a component of a mediator complex associated with RNA polymerase II, various studies suggest the involvement of Sin4 in the alteration of higher-order chromatin structure.", "output": {"entities": {"gene": [{"text": "SIN4 gene product", "start": 36, "end": 53}, {"text": "RNA polymerase II", "start": 107, "end": 124}, {"text": "Sin4", "start": 169, "end": 173}]}}, "schema": []}
{"input": "Src activation induced by FGF1 was blocked by the SH2 domain of Src and PP2, a specific inhibitor of Src.", "output": {"entities": {"gene": [{"text": "Src", "start": 0, "end": 3}, {"text": "FGF1", "start": 26, "end": 30}, {"text": "SH2 domain", "start": 50, "end": 60}, {"text": "Src", "start": 64, "end": 67}, {"text": "PP2", "start": 72, "end": 75}, {"text": "Src", "start": 101, "end": 104}]}}, "schema": []}
{"input": "The use of the PLCgamma inhibitory peptide, neomycin and the calcium chelator BAPTA-AM on oocytes expressing FGFR1 or the stimulation by PDGF-BB of oocytes expressing PDGFR-FGFR1 mutated on the PLCgamma binding site, prevented GVBD and ERK2 phosphorylation.", "output": {"entities": {"gene": [{"text": "PLCgamma inhibitory peptide", "start": 15, "end": 42}, {"text": "FGFR1", "start": 109, "end": 114}, {"text": "PDGF-BB", "start": 137, "end": 144}, {"text": "PDGFR", "start": 167, "end": 172}, {"text": "FGFR1", "start": 173, "end": 178}, {"text": "PLCgamma binding site", "start": 194, "end": 215}, {"text": "ERK2", "start": 236, "end": 240}]}}, "schema": []}
{"input": "Multiple transcription start sites were revealed by primer extension analysis of the mouse gene, and transfection constructs containing the prospective promoter generated transcriptional activity comparable to that of the SV40 promoter.", "output": {"entities": {"gene": [{"text": "SV40 promoter", "start": 222, "end": 235}]}}, "schema": []}
{"input": "To determine whether interaction of arsenite with the hormone-binding domain results in receptor activation, COS-1 cells were transiently cotransfected with the chimeric receptors GAL-ER, which contains the hormone-binding domain of ERalpha and the DNA-binding domain of the transcription factor GAL4, and a GAL4-responsive CAT reporter gene.", "output": {"entities": {"gene": [{"text": "chimeric receptors GAL-ER", "start": 161, "end": 186}, {"text": "ERalpha", "start": 233, "end": 240}, {"text": "GAL4", "start": 296, "end": 300}, {"text": "GAL4", "start": 308, "end": 312}, {"text": "CAT reporter gene", "start": 324, "end": 341}]}}, "schema": []}
{"input": "The mean day of diagnosis of periventricular echodensities was 3 +/-2 days (range 1-11 days), and of cystic PVL 21 +/-8 days (range 2-47 days).", "output": {"entities": {}}, "schema": []}
{"input": "The LAMMER protein kinase encoded by the Doa locus of Drosophila is required in both somatic and germline cells and is expressed as both nuclear and cytoplasmic isoforms throughout development.", "output": {"entities": {"gene": [{"text": "LAMMER", "start": 4, "end": 10}, {"text": "Doa locus", "start": 41, "end": 50}]}}, "schema": []}
{"input": "We have mutated to cysteine, one at a time, 21 consecutive residues in the fourth TMS (TM4).", "output": {"entities": {}}, "schema": []}
{"input": "(1995) J.", "output": {"entities": {}}, "schema": []}
{"input": "HYPOTHESIS: The aim of this study was to investigate the oxidative susceptibility of apolipoprotein B-containing lipoproteins and antioxidant status in patients with acute coronary syndromes and chronic stable angina pectoris.", "output": {"entities": {"gene": [{"text": "apolipoprotein B-containing lipoproteins", "start": 85, "end": 125}]}}, "schema": []}
{"input": "In group B 37 MBq in 150 microL of 99mTc-HSA nanocolloid was additionally injected intradermally 18 h before surgery (3-6 aliquots injected perilesionally).", "output": {"entities": {}}, "schema": []}
{"input": "Post-operative functional outcome is related to pre-operative functional status.", "output": {"entities": {}}, "schema": []}
{"input": "We cloned a DNA fragment encoding the N-terminal part of a protein with significant similarity to members of the LysR family of transcriptional regulators (LTTRs).", "output": {"entities": {"gene": [{"text": "LysR family of transcriptional regulators", "start": 113, "end": 154}, {"text": "LTTRs", "start": 156, "end": 161}]}}, "schema": []}
{"input": "AGO1 is similar to QDE-2 required for quelling and RDE-1 required for RNAi.", "output": {"entities": {"gene": [{"text": "AGO1", "start": 0, "end": 4}, {"text": "QDE-2", "start": 19, "end": 24}, {"text": "RDE-1", "start": 51, "end": 56}]}}, "schema": []}
{"input": "We could demonstrate the involvement of cAMP-dependent protein kinase (PKA) in the phosphorylation of CDC25Mm in fibroblasts overexpressing this RasGEF as well as in mouse brain synaptosomal membranes.", "output": {"entities": {"gene": [{"text": "cAMP-dependent protein kinase", "start": 40, "end": 69}, {"text": "PKA", "start": 71, "end": 74}, {"text": "CDC25Mm", "start": 102, "end": 109}, {"text": "RasGEF", "start": 145, "end": 151}]}}, "schema": []}
{"input": "We find that 3T1-3T2 mixing has a pronounced effect on the line shape and radiative decay rate of emission from the 3T2 state and that the extent of mixing depends critically on the magnitude of nontetrahedral distortions.", "output": {"entities": {}}, "schema": []}
{"input": "A total of 576 1-day-old Ross broiler chicks were housed in six treatment groups [six replicates of 16 each; control, CLI (15 g kg (-1) diet), 50 parts per billion (ppb) AF, 50 ppb AF plus CLI, 100 ppb AF, 100 ppb AF plus CLI] for 42 days.", "output": {"entities": {"gene": [{"text": "AF", "start": 170, "end": 172}, {"text": "AF", "start": 181, "end": 183}, {"text": "AF", "start": 202, "end": 204}, {"text": "AF", "start": 214, "end": 216}]}}, "schema": []}
{"input": "The cost per test is less than those for CC, kEIA and PACE2.", "output": {"entities": {}}, "schema": []}
{"input": "Concurrently, we monitored weather conditions and used time-activity budget data of free-living birds and laboratory data on resting metabolic rate to construct time-activity laboratory (TAL) estimates of daily energy expenditure (DEE) and to partition the verdins' energy budget into thermoregulatory, activity and basal components.", "output": {"entities": {}}, "schema": []}
{"input": "L/H > 0. 61 (chi (2) = 10. 8; P: < 0. 001) and a restrictive filling pattern (chi (2) = 3. 6; P: < 0. 05) were independent predictors of events.", "output": {"entities": {}}, "schema": []}
{"input": "The high selectivity of arrestins for this particular functional form of receptor ensures their timely binding and dissociation.", "output": {"entities": {"gene": [{"text": "arrestins", "start": 24, "end": 33}]}}, "schema": []}
{"input": "When cotransfected in fibroblasts with a C/EBP alpha expression vector, reporter gene expression increased 3-fold only in the wild-type constructs.", "output": {"entities": {"gene": [{"text": "C/EBP alpha", "start": 41, "end": 52}]}}, "schema": []}
{"input": "Expression of a dominant negative Smad2 significantly reduces the level of luciferase reporter activity induced by nodal treatment.", "output": {"entities": {"gene": [{"text": "dominant negative Smad2", "start": 16, "end": 39}, {"text": "luciferase reporter", "start": 75, "end": 94}]}}, "schema": []}
{"input": "Normal alpha1 (I) collagen mRNA showed no significant reduction when AR or IR was expressed from the pHbetaAPr-1-neo vector and a small (10-20%) but significant reduction when either ribozyme was expressed from the pCI. neo vector.", "output": {"entities": {"gene": [{"text": "alpha1 (I) collagen mRNA", "start": 7, "end": 31}]}}, "schema": []}
{"input": "Nature 398, 828-830) that the amino acid sequences of peptide fragments obtained from a polypeptide found in a complex of proteins that alters chromatin structure (ARC) are identical to portions of the deduced open reading frame of TIG-1 mRNA.", "output": {"entities": {"gene": [{"text": "ARC", "start": 164, "end": 167}, {"text": "TIG-1 mRNA", "start": 232, "end": 242}]}}, "schema": []}
{"input": "Abnormalities of plasma cholecystokinin were observed only in patients with delayed gastric emptying.", "output": {"entities": {"gene": [{"text": "plasma cholecystokinin", "start": 17, "end": 39}]}}, "schema": []}
{"input": "5 (Sunset Yellow FCF) were determined using liquid chromatography/mass spectrometry (LC/MS) with electrospray ionization.", "output": {"entities": {}}, "schema": []}
{"input": "Cam kinase II induces in vivo phosphorylation of Smad2 and Smad4 and, to a lesser extent, Smad3.", "output": {"entities": {"gene": [{"text": "Cam kinase II", "start": 0, "end": 13}, {"text": "Smad2", "start": 49, "end": 54}, {"text": "Smad4", "start": 59, "end": 64}, {"text": "Smad3", "start": 90, "end": 95}]}}, "schema": []}
{"input": "This interaction inhibits the histone acetyltransferase activity of p300, resulting in drastic reduction of nucleosomal histone acetylation and alteration of chromatin structure.", "output": {"entities": {"gene": [{"text": "histone acetyltransferase", "start": 30, "end": 55}, {"text": "p300", "start": 68, "end": 72}, {"text": "histone", "start": 120, "end": 127}]}}, "schema": []}
{"input": "Recombinant BRI1-KD autophosphorylated on serine (Ser) and threonine (Thr) residues with p-Ser predominating.", "output": {"entities": {"gene": [{"text": "Recombinant BRI1-KD", "start": 0, "end": 19}]}}, "schema": []}
{"input": "Flow cytomery was used for cell cycle analysis.", "output": {"entities": {}}, "schema": []}
{"input": "Further research is required to better measure treatment effects, modification of MS natural history, and net societal costs of IFN beta-1b in RRMS.", "output": {"entities": {"gene": [{"text": "IFN beta-1b", "start": 128, "end": 139}]}}, "schema": []}
{"input": "Cost-effectiveness of interferon beta-1b in slowing multiple sclerosis disability progression.", "output": {"entities": {"gene": [{"text": "interferon beta-1b", "start": 22, "end": 40}]}}, "schema": []}
{"input": "Both the Cmax and AUC values were almost doubled with doubling the dose.", "output": {"entities": {}}, "schema": []}
{"input": "Hyperactivation of Cdc2 in fission yeast causes cells to undergo a lethal premature mitosis called mitotic catastrophe.", "output": {"entities": {"gene": [{"text": "Cdc2", "start": 19, "end": 23}]}}, "schema": []}
{"input": "Diary.", "output": {"entities": {}}, "schema": []}
{"input": "Cells differentiate in response to various extracellular stimuli.", "output": {"entities": {}}, "schema": []}
{"input": "Transforming growth factor-beta1 (TGF-beta1) can act as a tumor suppressor or a tumor promoter depending on the characteristics of the malignant cell.", "output": {"entities": {"gene": [{"text": "Transforming growth factor-beta1", "start": 0, "end": 32}, {"text": "TGF-beta1", "start": 34, "end": 43}]}}, "schema": []}
{"input": "Mn2 + increased both the junction binding and cleaving activities of the mutant proteins.", "output": {"entities": {}}, "schema": []}
{"input": "While Pt; cycH; 1 and Os; cycH; 1 were expressed in all tissues examined, the transcripts accumulated abundantly in dividing cells.", "output": {"entities": {"gene": [{"text": "Pt; cycH; 1", "start": 6, "end": 17}, {"text": "Os; cycH; 1", "start": 22, "end": 33}]}}, "schema": []}
{"input": "Moreover, an in vitro pull-down assay showed that Os; CycH; 1 specifically bound to R2 but not to other rice CDKs.", "output": {"entities": {"gene": [{"text": "Os; CycH; 1", "start": 50, "end": 61}, {"text": "R2", "start": 84, "end": 86}, {"text": "rice CDKs", "start": 104, "end": 113}]}}, "schema": []}
{"input": "In transient analysis using particle bombardment of tobacco leaf sections, a tetramer of the distB ABRE (abscisic acid-responsive element) mediated transactivation by ABI3 and ABI3-dependent response to ABA, whereas a tetramer of the composite RY/G complex, containing RY repeats and a G-box, mediated only ABA-independent transactivation by ABI3.", "output": {"entities": {"gene": [{"text": "ABI3", "start": 167, "end": 171}, {"text": "ABI3", "start": 176, "end": 180}, {"text": "ABI3", "start": 342, "end": 346}]}}, "schema": []}
{"input": "The major neurological manifestations of brain injury in these babies are spastic motor deficits.", "output": {"entities": {}}, "schema": []}
{"input": "Spores from Rhizopus stolonifer were suspended in distilled water (1 x 10 (6) spores/mL) and used as starter.", "output": {"entities": {}}, "schema": []}
{"input": "The LMW FGF-2 up-regulated the PKC epsilon levels by 1. 6-fold; by contrast the HMW isoform down-regulated the level of this PKC isotype by about 3-fold and increased the amount of PKC delta by 1. 7-fold.", "output": {"entities": {"gene": [{"text": "LMW FGF-2", "start": 4, "end": 13}, {"text": "PKC epsilon", "start": 31, "end": 42}, {"text": "HMW isoform", "start": 80, "end": 91}, {"text": "PKC isotype", "start": 125, "end": 136}, {"text": "PKC delta", "start": 181, "end": 190}]}}, "schema": []}
{"input": "Helicobacter pylori and stomach diseases: from clinical point of view", "output": {"entities": {}}, "schema": []}
{"input": "For this purpose, the writhing test, capsaicin and formalin induced-pain in mice were used.", "output": {"entities": {}}, "schema": []}
{"input": "2000 update of recommendations for the use of hematopoietic colony-stimulating factors: evidence-based, clinical practice guidelines.", "output": {"entities": {"gene": [{"text": "hematopoietic colony-stimulating factors", "start": 46, "end": 86}]}}, "schema": []}
{"input": "Prominent findings were chronic pancreatitis with acinar and ductal plugs, granulomatous and necrotizing peripancreatic steatitis, degenerative myopathy, testicular atrophy, candidiasis and bacterial necrotizing glossitis.", "output": {"entities": {}}, "schema": []}
{"input": "Taken together, our data indicate that multiple survival pathways are triggered via this receptor, whereas NF-kappaB/Rel and PI-3K are crucial for CD40-induced proliferation.", "output": {"entities": {"gene": [{"text": "NF-kappaB", "start": 107, "end": 116}, {"text": "Rel", "start": 117, "end": 120}, {"text": "PI-3K", "start": 125, "end": 130}, {"text": "CD40", "start": 147, "end": 151}]}}, "schema": []}
{"input": "In vitro, Arix and NBPhox form DNA-independent multimers and exhibit cooperative binding to the DB1 regulatory element, which contains two homeodomain recognition sites.", "output": {"entities": {"gene": [{"text": "Arix", "start": 10, "end": 14}, {"text": "NBPhox", "start": 19, "end": 25}, {"text": "DB1 regulatory element", "start": 96, "end": 118}, {"text": "homeodomain recognition sites", "start": 139, "end": 168}]}}, "schema": []}
{"input": "We conclude from this study that Arix and NBPhox exhibit indistinguishable and independent transcriptional regulatory properties on the DBH promoter.", "output": {"entities": {"gene": [{"text": "Arix", "start": 33, "end": 37}, {"text": "NBPhox", "start": 42, "end": 48}, {"text": "DBH promoter", "start": 136, "end": 148}]}}, "schema": []}
{"input": "METHODS AND RESULTS: Studies were undertaken in 9 isolated guinea pig hearts, which demonstrated reverse use-dependent prolongation of cardiac repolarization by 100 nmol/L domperidone.", "output": {"entities": {}}, "schema": []}
{"input": "OBJECTIVE: To evaluate the overall performance of a new oscillometric wrist blood pressure monitor (Braun PrecisionSensor, Braun GmbH, Kronberg, Germany) as defined by the ANSI/AAMI SP10-1992 guidelines, and to analyze the data for the optimized selection of the algorithm that derives the blood pressure values from the oscillometric blood pressure curves.", "output": {"entities": {}}, "schema": []}
{"input": "Following the results of toxicological experiments in the target animals \" Toxicological Drinking Water Standards for Animals \" can be established.", "output": {"entities": {}}, "schema": []}
{"input": "An increase in hypothalamic expression of at least two of the erbB receptors is initiated before the pubertal augmentation of gonadal steroid secretion and is completed on the day of the first preovulatory surge of gonadotropins.", "output": {"entities": {"gene": [{"text": "erbB receptors", "start": 62, "end": 76}, {"text": "gonadotropins", "start": 215, "end": 228}]}}, "schema": []}
{"input": "Dsh is required for two different pathways, the Wnt pathway and planar polarity pathway in Drosophila.", "output": {"entities": {"gene": [{"text": "Dsh", "start": 0, "end": 3}, {"text": "Wnt", "start": 48, "end": 51}]}}, "schema": []}
{"input": "Catch-up growth and craniofacial dimensions following administration of the antineoplastic agent vincristine to young rats.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS: LSCC malformation, like other inner ear malformations such as large vestibular aqueduct and X-linked mixed deafness with perilymph gusher, can be associated with CHL, SNHL, or normal hearing.", "output": {"entities": {}}, "schema": []}
{"input": "Escalation to 180 mg/m2 was to be carried out if white blood cell nadir count was > 2. 0 x 10 (9)/l and platelet nadir count was > 75 x 10 (9)/l.", "output": {"entities": {}}, "schema": []}
{"input": "Methyl formate was used as the solvent of biodegradable oligoesters for the fabrication of microspheres with encapsulated bovine serum albumin (BSA).", "output": {"entities": {"gene": [{"text": "bovine serum albumin", "start": 122, "end": 142}, {"text": "BSA", "start": 144, "end": 147}]}}, "schema": []}
{"input": "The small monomeric GTP-binding proteins of the RAB subfamily are key regulatory elements of the machinery that controls membrane traffic in eukaryotic cells.", "output": {"entities": {"gene": [{"text": "small monomeric GTP-binding proteins", "start": 4, "end": 40}, {"text": "RAB subfamily", "start": 48, "end": 61}]}}, "schema": []}
{"input": "Furthermore, loss of methylation also greatly reduced the association of another yeast B-type subunit, Rts1p.", "output": {"entities": {"gene": [{"text": "Rts1p", "start": 103, "end": 108}]}}, "schema": []}
{"input": "Thus, methylation of Pph21p is important for formation of PP2A trimeric and dimeric complexes, and consequently, for PP2A function.", "output": {"entities": {"gene": [{"text": "Pph21p", "start": 21, "end": 27}, {"text": "PP2A trimeric and dimeric complexes", "start": 58, "end": 93}, {"text": "PP2A", "start": 117, "end": 121}]}}, "schema": []}
{"input": "The purpose of this study was to analyze the temporal characteristics and the spatial mapping of the independent components identified by ICA when the subject performs a finger-tapping task.", "output": {"entities": {}}, "schema": []}
{"input": "The authors present the only two studies that have proved successful in treating animal models of osteoarthritis using gene therapy, and propose an overview of several strategies for the development of gene therapy in osteoarthritis treatment in the future.", "output": {"entities": {}}, "schema": []}
{"input": "Together, these results indicate that IL-1 beta induces VEGF gene expression at both transcriptional and post-transcriptional levels, and IL-1 beta evokes p38 MAPK and JNK signalings, which in turn stimulate the transcription of the VEGF gene through Sp1-binding sites.", "output": {"entities": {"gene": [{"text": "IL-1 beta", "start": 38, "end": 47}, {"text": "VEGF gene", "start": 56, "end": 65}, {"text": "IL-1 beta", "start": 138, "end": 147}, {"text": "p38", "start": 155, "end": 158}, {"text": "JNK", "start": 168, "end": 171}, {"text": "VEGF gene", "start": 233, "end": 242}, {"text": "Sp1-binding sites", "start": 251, "end": 268}]}}, "schema": []}
{"input": "Binding of NusA to RNA in the presence of alpha or N involves an amino-terminal S1 homology region that is otherwise inactive in full-length NusA.", "output": {"entities": {"gene": [{"text": "NusA", "start": 11, "end": 15}, {"text": "amino-terminal S1 homology region", "start": 65, "end": 98}, {"text": "full-length NusA", "start": 129, "end": 145}]}}, "schema": []}
{"input": "The subjects were diagnosed on the basis of DSM-IV pathological gambling criteria and completed the Turkish Version of South Oaks Gambling Screen (SOGS).", "output": {"entities": {}}, "schema": []}
{"input": "Lys (193) and Arg (194), located at the COOH-terminal end of HD, are essential for dimerization.", "output": {"entities": {"gene": [{"text": "HD", "start": 61, "end": 63}]}}, "schema": []}
{"input": "Elevation of intracellular Ca (2 +) levels are also involved because treatment with receptor-associated protein, nifedipine, MK801, removal of Ca (2 +) from the medium and dantrolene all served to inhibit calcium elevation and attenuate the activation of CREB.", "output": {"entities": {"gene": [{"text": "CREB", "start": 255, "end": 259}]}}, "schema": []}
{"input": "The present study shows that phosphatidylinositol 3-kinase-dependent p38 kinase activation regulates Akt phosphorylation and activity in human neutrophils.", "output": {"entities": {"gene": [{"text": "phosphatidylinositol 3-kinase", "start": 29, "end": 58}, {"text": "p38 kinase", "start": 69, "end": 79}, {"text": "Akt", "start": 101, "end": 104}]}}, "schema": []}
{"input": "When BFDS was taken as the reference, W/A Z scores showed consistent positive increments, from birth in girls and 1 mo in boys.", "output": {"entities": {}}, "schema": []}
{"input": "Using purified recombinant HMG I, we have identified several high-affinity binding sites which overlap important transcription factor binding sites.", "output": {"entities": {"gene": [{"text": "recombinant HMG I", "start": 15, "end": 32}]}}, "schema": []}
{"input": "High-mobility-group protein I can modulate binding of transcription factors to the U5 region of the human immunodeficiency virus type 1 proviral promoter.", "output": {"entities": {"gene": [{"text": "High-mobility-group protein I", "start": 0, "end": 29}, {"text": "U5 region", "start": 83, "end": 92}, {"text": "human immunodeficiency virus type 1 proviral promoter", "start": 100, "end": 153}]}}, "schema": []}
{"input": "Leptinaemia does not correlate with the actual or mean blood pressure reading nor with stage of hypertension according to the WHO classification.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, diamide treatment of nuclear extracts strongly reduces the binding of NFI proteins, and the addition of higher concentrations of dithiothreitol to nuclear extracts from TG-treated cells restores NFI-DNA binding to levels in extracts from untreated cells.", "output": {"entities": {"gene": [{"text": "NFI proteins", "start": 76, "end": 88}, {"text": "TG", "start": 175, "end": 177}, {"text": "NFI-DNA", "start": 201, "end": 208}]}}, "schema": []}
{"input": "LMP2A enhances Lyn and Syk ubiquitination in vivo in a fashion that depends on the activity of Nedd4 family members and correlates with destabilization of the Lyn tyrosine kinase.", "output": {"entities": {"gene": [{"text": "LMP2A", "start": 0, "end": 5}, {"text": "Lyn", "start": 15, "end": 18}, {"text": "Syk", "start": 23, "end": 26}, {"text": "Nedd4", "start": 95, "end": 100}, {"text": "Lyn tyrosine kinase", "start": 159, "end": 178}]}}, "schema": []}
{"input": "Further, Tax-mediated apoptosis was effectively prevented by ectopic expression of the p300 coactivator.", "output": {"entities": {"gene": [{"text": "Tax", "start": 9, "end": 12}, {"text": "p300 coactivator", "start": 87, "end": 103}]}}, "schema": []}
{"input": "Our results, however, were obtained for Z itself and not for [Z].", "output": {"entities": {}}, "schema": []}
{"input": "Fisher' s exact test or Pearson' s chi2 test were used for statistical analysis.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: In the pregnant group, serum PP14 concentrations were markedly increased after ET, and a significant difference between the pregnant group and the nonpregnant group was observed 8 days following ET (p < 0. 01).", "output": {"entities": {"gene": [{"text": "PP14", "start": 38, "end": 42}]}}, "schema": []}
{"input": "High expression of the peroxisome proliferator-activated receptor alpha (PPARalpha) differentiates brown fat from white, and is related to its high capacity of lipid oxidation.", "output": {"entities": {"gene": [{"text": "peroxisome proliferator-activated receptor alpha", "start": 23, "end": 71}, {"text": "PPARalpha", "start": 73, "end": 82}]}}, "schema": []}
{"input": "This-2485/-2458 element bound PPARalpha and PPARgamma from brown fat nuclei.", "output": {"entities": {"gene": [{"text": "PPARalpha", "start": 30, "end": 39}, {"text": "PPARgamma", "start": 44, "end": 53}]}}, "schema": []}
{"input": "These results provide direct evidence for differential susceptibility to endonuclease-mediated mRNA decay resulting from the differential affinity of a RNA-binding protein for cis-acting stability determinants.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: Twenty-two (26%) patients had PHG before (group A) and 64 (74%) developed PHG after variceal eradication (group B).", "output": {"entities": {}}, "schema": []}
{"input": "Response was extremely poor in African Americans and those with HCV genotype 1.", "output": {"entities": {}}, "schema": []}
{"input": "Aspirin causes peptic ulcers predominately by reducing gastric mucosal cyclooxygenase (COX) activity and prostaglandin synthesis.", "output": {"entities": {"gene": [{"text": "gastric mucosal cyclooxygenase", "start": 55, "end": 85}, {"text": "COX", "start": 87, "end": 90}]}}, "schema": []}
{"input": "A total of 1060 clones were randomly selected for sequencing of one end.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS: The surgical or multimodality treatment of MSGT has provided a good locoregional control (78%) and 68% 10-year survival in a series of patients treated at the oncology department of a general hospital in Quito, Ecuador.", "output": {"entities": {}}, "schema": []}
{"input": "The gene is separated into four exons by three short introns, and the open reading frame consists of 6660 base pairs (bp) capable of encoding a polypeptide of 2220 amino acid residues.", "output": {"entities": {}}, "schema": []}
{"input": "Like the p190-B exon, the first exon of p190-A is extremely large (3. 7 kb in length), encoding both the GTPase and middle domains (residues 1-1228), but not the remaining GAP domain, suggesting a high conservation of genomic structure between two p190 genes.", "output": {"entities": {"gene": [{"text": "p190-B", "start": 9, "end": 15}, {"text": "p190-A", "start": 40, "end": 46}, {"text": "GTPase", "start": 105, "end": 111}, {"text": "GAP domain", "start": 172, "end": 182}, {"text": "p190 genes", "start": 248, "end": 258}]}}, "schema": []}
{"input": "The entire human teneurin-1 (TEN1) gene is contained in eight PAC clones representing part of the chromosomal locus Xq25.", "output": {"entities": {"gene": [{"text": "human teneurin-1", "start": 11, "end": 27}, {"text": "TEN1", "start": 29, "end": 33}]}}, "schema": []}
{"input": "The plexiform neurofibroma and multiple localized neurofibromas are characteristic of NF1.", "output": {"entities": {"gene": [{"text": "NF1", "start": 86, "end": 89}]}}, "schema": []}
{"input": "In general lookback, all patients who received blood before being tested for hepatitis C are advised to undergo testing.", "output": {"entities": {}}, "schema": []}
{"input": "The proposed algorithm consists of several steps.", "output": {"entities": {}}, "schema": []}
{"input": "It contained seven extra amino acids of FVVLNLQ; this short stretch of extra sequence was found between Gln (421) and Phe (422) within the SET (Suvar3-9, Enhancer-of-zeste, Trithorax) interacting domain (SID) of rMTM.", "output": {"entities": {"gene": [{"text": "SET", "start": 139, "end": 142}, {"text": "Suvar3-9", "start": 144, "end": 152}, {"text": "Enhancer-of-zeste", "start": 154, "end": 171}, {"text": "Trithorax", "start": 173, "end": 182}, {"text": "rMTM", "start": 212, "end": 216}]}}, "schema": []}
{"input": "MED1 has a weak glycosylase activity on the mutagenic adduct 3, N (4)-ethenocytosine, a metabolite of vinyl chloride and ethyl carbamate.", "output": {"entities": {"gene": [{"text": "MED1", "start": 0, "end": 4}, {"text": "glycosylase", "start": 16, "end": 27}]}}, "schema": []}
{"input": "There were no instances of major flap necrosis although two flaps showed tip ischaemia.", "output": {"entities": {}}, "schema": []}
{"input": "These results suggest that XAB1 is a novel cytoplasmic GTPase involved in nuclear localization of XPA.", "output": {"entities": {"gene": [{"text": "XAB1", "start": 27, "end": 31}, {"text": "cytoplasmic GTPase", "start": 43, "end": 61}, {"text": "XPA", "start": 98, "end": 101}]}}, "schema": []}
{"input": "One of these factors, IRF-2, was initially cloned as an antagonistic counterpart to IRF-1 with oncogenic potential.", "output": {"entities": {"gene": [{"text": "IRF-2", "start": 22, "end": 27}, {"text": "IRF-1", "start": 84, "end": 89}]}}, "schema": []}
{"input": "Among the total CDSs, 8. 8% match sequences of proteins found only in Bacillus subtilis and 66. 7% are widely conserved in comparison with the proteins of various organisms, including B. subtilis.", "output": {"entities": {}}, "schema": []}
{"input": "Tobramycin-loaded SLN administered i. v. showed a prolonged circulation time compared to the i. v. administered tobramycin solution.", "output": {"entities": {}}, "schema": []}
{"input": "Bacteriol.", "output": {"entities": {}}, "schema": []}
{"input": "Terminal deoxynucleotidyl transferase-mediated nick end labeling assays revealed that hormonal activation of the PAX3 repressors induced extensive apoptosis that correlated with down-regulation of BCL-X (L) expression.", "output": {"entities": {"gene": [{"text": "Terminal deoxynucleotidyl transferase", "start": 0, "end": 37}, {"text": "PAX3 repressors", "start": 113, "end": 128}, {"text": "BCL-X (L)", "start": 197, "end": 206}]}}, "schema": []}
{"input": "VEGF promoter activity in transient transfections was decreased by either pharmacological or genetic inhibition of EGFR, Ras, or phosphatidylinositol 3'-kinase [PI (3) kinase].", "output": {"entities": {"gene": [{"text": "VEGF promoter", "start": 0, "end": 13}, {"text": "EGFR", "start": 115, "end": 119}, {"text": "Ras", "start": 121, "end": 124}, {"text": "phosphatidylinositol 3'-kinase [PI (3) kinase]", "start": 129, "end": 175}]}}, "schema": []}
{"input": "Epidermal growth factor receptor transcriptionally up-regulates vascular endothelial growth factor expression in human glioblastoma cells via a pathway involving phosphatidylinositol 3'-kinase and distinct from that induced by hypoxia.", "output": {"entities": {"gene": [{"text": "Epidermal growth factor receptor", "start": 0, "end": 32}, {"text": "vascular endothelial growth factor", "start": 64, "end": 98}, {"text": "phosphatidylinositol 3'-kinase", "start": 162, "end": 192}]}}, "schema": []}
{"input": "Thus, IHHNV is closely related to densoviruses of the genus Brevidensovirus in the family Parvoviridae, and we therefore propose to rename this virus Penaeus stylirostris densovirus (PstDNV).", "output": {"entities": {}}, "schema": []}
{"input": "Stress-activated protein kinase 1 (SAPK1), also called c-Jun N-terminal kinase (JNK), becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses.", "output": {"entities": {"gene": [{"text": "Stress-activated protein kinase 1", "start": 0, "end": 33}, {"text": "SAPK1", "start": 35, "end": 40}, {"text": "c-Jun N-terminal kinase", "start": 55, "end": 78}, {"text": "JNK", "start": 80, "end": 83}]}}, "schema": []}
{"input": "Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation.", "output": {"entities": {"gene": [{"text": "mitogen-activated protein (MAP) kinase phosphatase-1", "start": 24, "end": 76}, {"text": "p38 MAP kinase", "start": 91, "end": 105}, {"text": "p38 C-terminal domain", "start": 128, "end": 149}]}}, "schema": []}
{"input": "Thus, the class C-Vps complex directs multiple reactions during the docking and fusion of vesicles with the vacuole, each of which contributes to the overall specificity and efficiency of this transport process.", "output": {"entities": {"gene": [{"text": "class C", "start": 10, "end": 17}, {"text": "Vps", "start": 18, "end": 21}]}}, "schema": []}
{"input": "Combined intravenous and intra-arterial recombinant tissue plasminogen activator in acute ischemic stroke.", "output": {"entities": {"gene": [{"text": "tissue plasminogen activator", "start": 52, "end": 80}]}}, "schema": []}
{"input": "Signal transduction via modulation of phosphorylation after selective inhibition of protein phosphatase (PP) 1 and/or PP2A appears to play a role in okadaic acid (OA)-mediated effects.", "output": {"entities": {"gene": [{"text": "protein phosphatase (PP) 1", "start": 84, "end": 110}, {"text": "PP2A", "start": 118, "end": 122}]}}, "schema": []}
{"input": "Exon A is located approximately 7 kb 5' to the HSL translation start site.", "output": {"entities": {"gene": [{"text": "HSL translation start site", "start": 47, "end": 73}]}}, "schema": []}
{"input": "NF-kappaB is a redox-sensitive transcription factor known to be activated by oxidative stress as well as chemical and biological reductants.", "output": {"entities": {"gene": [{"text": "NF-kappaB", "start": 0, "end": 9}]}}, "schema": []}
{"input": "Cardiovascular risk factors and antihypertensive treatment.", "output": {"entities": {}}, "schema": []}
{"input": "What to look for during a compliance review: 10 common mistakes made by SNFs.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS: EBCT technology allows minimally invasive evaluation of intramyocardial microcirculatory function and permits assessment of microvascular BV distribution in different functional components.", "output": {"entities": {}}, "schema": []}
{"input": "These two mAbs used the same V (H) and J (H) gene segments, but different D, Vkappa, and Jkappa genes.", "output": {"entities": {}}, "schema": []}
{"input": "SSF experiments were carried out in bench-scale bioreactors (equipped with CO2 and volatile organic traps) containing a mixture of lignocellulosic materials and a radiolabeled pesticide.", "output": {"entities": {}}, "schema": []}
{"input": "Characterization of a Xenopus laevis CXC chemokine receptor 4: implications for hematopoietic cell development in the vertebrate embryo.", "output": {"entities": {"gene": [{"text": "Xenopus laevis CXC chemokine receptor 4", "start": 22, "end": 61}]}}, "schema": []}
{"input": "Patients had to have adequate liver, renal, and marrow functions.", "output": {"entities": {}}, "schema": []}
{"input": "Inhibition of RNA2 translation was selective, with no effect on general cellular translation or translation of BMV RNA1-encoded replication factor 1a, and was independent of p20, a cellular antagonist of DED1 function in translation.", "output": {"entities": {"gene": [{"text": "RNA2", "start": 14, "end": 18}, {"text": "RNA1", "start": 115, "end": 119}, {"text": "replication factor 1a", "start": 128, "end": 149}, {"text": "p20", "start": 174, "end": 177}, {"text": "DED1", "start": 204, "end": 208}]}}, "schema": []}
{"input": "Abbreviations: CAS, CRK-associated substrate; CH, calponin-homology domain; CSK, C-terminal SRC kinase; E6, Papillomavirus E6 protein; FAK, focal adhesion kinase; GIT, GRK interacter; GPCR, heterotrimeric-G-protein-coupled receptor; GRK, G-protein-coupled-receptor kinase; MAPK, mitogen-activated protein kinase (ERK, p38, JNK); PAK, p21-activated kinase; PBS, paxillin-binding subdomain; PIX, PAK-interacting exchange factor; PKL, paxillin kinase linker; POR1, partner of Rac; PS, phosphoserine; PT, phosphothreonine; PY, phosphotyrosine; RTK, growth factor receptor tyrosine kinase; SH, SRC-homology domain.", "output": {"entities": {"gene": [{"text": "CAS", "start": 15, "end": 18}, {"text": "CRK-associated substrate", "start": 20, "end": 44}, {"text": "CH", "start": 46, "end": 48}, {"text": "calponin-homology domain", "start": 50, "end": 74}, {"text": "CSK", "start": 76, "end": 79}, {"text": "C-terminal SRC kinase", "start": 81, "end": 102}, {"text": "E6", "start": 104, "end": 106}, {"text": "Papillomavirus E6 protein", "start": 108, "end": 133}, {"text": "FAK", "start": 135, "end": 138}, {"text": "focal adhesion kinase", "start": 140, "end": 161}, {"text": "GIT", "start": 163, "end": 166}, {"text": "GRK interacter", "start": 168, "end": 182}, {"text": "GPCR", "start": 184, "end": 188}, {"text": "heterotrimeric-G-protein-coupled receptor", "start": 190, "end": 231}, {"text": "GRK", "start": 233, "end": 236}, {"text": "G-protein-coupled-receptor kinase", "start": 238, "end": 271}, {"text": "MAPK", "start": 273, "end": 277}, {"text": "mitogen-activated protein kinase", "start": 279, "end": 311}, {"text": "ERK", "start": 313, "end": 316}, {"text": "p38", "start": 318, "end": 321}, {"text": "JNK", "start": 323, "end": 326}, {"text": "PAK", "start": 329, "end": 332}, {"text": "p21-activated kinase", "start": 334, "end": 354}, {"text": "PBS", "start": 356, "end": 359}, {"text": "paxillin-binding subdomain", "start": 361, "end": 387}, {"text": "PIX", "start": 389, "end": 392}, {"text": "PAK-interacting exchange factor", "start": 394, "end": 425}, {"text": "PKL", "start": 427, "end": 430}, {"text": "paxillin kinase linker", "start": 432, "end": 454}, {"text": "POR1", "start": 456, "end": 460}, {"text": "partner of Rac", "start": 462, "end": 476}, {"text": "RTK", "start": 540, "end": 543}, {"text": "growth factor receptor tyrosine kinase", "start": 545, "end": 583}, {"text": "SH", "start": 585, "end": 587}, {"text": "SRC-homology domain", "start": 589, "end": 608}]}}, "schema": []}
{"input": "In 15 ventilator-dependent, SB, and actively expiring patients, we found that the difference PEEP (i), dyn-Pga, total decay (mean +/-SD, 5. 7 +/-1. 9 cm H (2) O) was quite similar to PEEP (i), dyn ref (5. 3 +/-1. 9 cm H (2) O).", "output": {"entities": {}}, "schema": []}
{"input": "Of 208 eligible subjects, 82 received supervised IPT at a dose of 900 mg twice weekly for 6 mo (Regimen A), 73 received unsupervised IPT 900 mg twice weekly for 6 mo (Regimen B), and 53 received unsupervised IPT 300 mg daily for 6 mo (Regimen C).", "output": {"entities": {}}, "schema": []}
{"input": "There were 122 cases of tuberculosis over an average 10. 3 yr of follow-up (crude annual incidence, 76. 2/100, 000).", "output": {"entities": {}}, "schema": []}
{"input": "These results suggested that BACH1t recruits BACH1 to the nucleus through BTB domain-mediated interaction.", "output": {"entities": {"gene": [{"text": "BACH1t", "start": 29, "end": 35}, {"text": "BACH1", "start": 45, "end": 50}, {"text": "BTB", "start": 74, "end": 77}]}}, "schema": []}
{"input": "Transcription of the six EBNA genes, which are expressed in EBV-immortalized primary B cells, arises from one of two promoters, Cp and Wp, located near the left end of the viral genome.", "output": {"entities": {"gene": [{"text": "EBNA genes", "start": 25, "end": 35}, {"text": "Cp", "start": 128, "end": 130}, {"text": "Wp", "start": 135, "end": 137}]}}, "schema": []}
{"input": "Thus, blocks in the RARalpha-specific pathway of retinoid-induced differentiation may be bypassed during retinoid induction of FR-beta expression.", "output": {"entities": {"gene": [{"text": "RARalpha", "start": 20, "end": 28}, {"text": "FR-beta", "start": 127, "end": 134}]}}, "schema": []}
{"input": "Is more better? About dose levels of ACE inhibitors in chronic heart failure.", "output": {"entities": {"gene": [{"text": "ACE", "start": 37, "end": 40}]}}, "schema": []}
{"input": "To test whether or not SOCS-3 also binds to the IGFIR, we cloned human SOCS-3 by reverse transcription-polymerase chain reaction from human skeletal muscle mRNA.", "output": {"entities": {"gene": [{"text": "SOCS-3", "start": 23, "end": 29}, {"text": "IGFIR", "start": 48, "end": 53}, {"text": "human SOCS-3", "start": 65, "end": 77}]}}, "schema": []}
{"input": "A protein lacking the SH2 and RING finger domains has no activity, but a chimeric protein with the SH2 and RING finger domains of SLI-1 replaced by the equivalent domains of c-Cbl has activity.", "output": {"entities": {"gene": [{"text": "SH2", "start": 22, "end": 25}, {"text": "SH2", "start": 99, "end": 102}, {"text": "SLI-1", "start": 130, "end": 135}, {"text": "c-Cbl", "start": 174, "end": 179}]}}, "schema": []}
{"input": "To evaluate the effects of HRT on those factors in end-stage renal disease (ESRD) patients, we evaluated the changes of lipid profile, coagulation and fibrinolysis markers, and plasma homocysteine levels after treatment.", "output": {"entities": {}}, "schema": []}
{"input": "There was a weak significant correlation between TGF beta 1 levels and normal cell radiosensitivity (lymphocyte SF2).", "output": {"entities": {"gene": [{"text": "TGF beta 1", "start": 49, "end": 59}]}}, "schema": []}
{"input": "Acute feasibility and safety of a smoking reduction strategy for smokers with schizophrenia.", "output": {"entities": {}}, "schema": []}
{"input": "Tightly ordered proteasomal degradation of proteins critical for cell cycle control implies a role of the proteasome in maintaining cell proliferation and cell survival.", "output": {"entities": {}}, "schema": []}
{"input": "The sixth nucleotide was bulged out to allow stacking of this U. G pair on the adjacent helical region.", "output": {"entities": {}}, "schema": []}
{"input": "Functional analysis of the mutant desmin in SW13 (vim-) cells showed aggregation of abnormal coarse clumps of desmin positive material dispersed throughout the cytoplasm.", "output": {"entities": {"gene": [{"text": "mutant desmin", "start": 27, "end": 40}, {"text": "vim", "start": 50, "end": 53}, {"text": "desmin", "start": 110, "end": 116}]}}, "schema": []}
{"input": "Patients with lesions affecting the PRC but sparing the PHC, and patients with lesions affecting both PRC and PHC, performed an oculomotor delayed response task with unpredictably varied memory delays of up to 30 s.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, 26 amino acid residues, K69, D88, E94, D134, R154, K169, H197, D233, G235, G236, G237, F238, E274, G276, R277, Y278, K294, Y323, Y331, D332, C360, D361, D364, G387, Y389, and F397 (mouse ODC numbering), all of which are implicated in the formation of the pyridoxal phosphate-binding domain and the substrate-binding domain and in dimer stabilization with the eukaryotic ODCs, were also conserved in S. ruminantium LDC.", "output": {"entities": {"gene": [{"text": "ODC", "start": 200, "end": 203}, {"text": "ODCs", "start": 383, "end": 387}, {"text": "LDC", "start": 427, "end": 430}]}}, "schema": []}
{"input": "The Psc2 cDNA contained an open reading frame homologous to CP2 family proteins.", "output": {"entities": {"gene": [{"text": "Psc2 cDNA", "start": 4, "end": 13}, {"text": "CP2 family proteins", "start": 60, "end": 79}]}}, "schema": []}
{"input": "Our results indicate that Shh can drive continued cycling in immature, proliferating CGNPs.", "output": {"entities": {"gene": [{"text": "Shh", "start": 26, "end": 29}]}}, "schema": []}
{"input": "The QT interval was related to various components of the insulin resistance syndrome, including BP and insulin sensitivity.", "output": {"entities": {"gene": [{"text": "insulin", "start": 57, "end": 64}, {"text": "insulin", "start": 103, "end": 110}]}}, "schema": []}
{"input": "The wavenumbers corresponding to the normal modes of vibration were calculated using the DFT (B3LYP/6-31G * *) approximation and their agreement with the measured values improved after scaling of the associated force field.", "output": {"entities": {}}, "schema": []}
{"input": "The data provide strong evidence that ThlA is involved in the metabolism of both acid and solvent formation, whereas the physiological function of ThlB has yet to be elucidated.", "output": {"entities": {"gene": [{"text": "ThlA", "start": 38, "end": 42}, {"text": "ThlB", "start": 147, "end": 151}]}}, "schema": []}
{"input": "In addition, npm3, which is usually coactivated with fgf8 by MMTV insertion, was not up-regulated by androgens in SC-3 cells.", "output": {"entities": {"gene": [{"text": "npm3", "start": 13, "end": 17}, {"text": "fgf8", "start": 53, "end": 57}]}}, "schema": []}
{"input": "Experiments with epitope-tagged proteins show that UEV1A is a nuclear protein, whereas both Kua and Kua-UEV localize to cytoplasmic structures, indicating that the Kua domain determines the cytoplasmic localization of Kua-UEV.", "output": {"entities": {"gene": [{"text": "UEV1A", "start": 51, "end": 56}, {"text": "Kua", "start": 92, "end": 95}, {"text": "Kua", "start": 100, "end": 103}, {"text": "UEV", "start": 104, "end": 107}, {"text": "Kua domain", "start": 164, "end": 174}, {"text": "Kua", "start": 218, "end": 221}, {"text": "UEV", "start": 222, "end": 225}]}}, "schema": []}
{"input": "Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription. p53 protein activity as a transcription factor can be activated in vivo by antibodies that target its C-terminal negative regulatory domain suggesting that cellular enzymes that target this domain may play a role in stimulating p53-dependent gene expression.", "output": {"entities": {"gene": [{"text": "human p53", "start": 34, "end": 43}, {"text": "p53", "start": 65, "end": 68}, {"text": "p53 protein", "start": 94, "end": 105}, {"text": "p53", "start": 322, "end": 325}]}}, "schema": []}
{"input": "Interestingly, this mutant cell line lacks expression of the IKK regulatory protein, IKKgamma.", "output": {"entities": {"gene": [{"text": "IKK regulatory protein", "start": 61, "end": 83}, {"text": "IKKgamma", "start": 85, "end": 93}]}}, "schema": []}
{"input": "The Tax/IKKgamma interaction serves to recruit Tax to the IKK catalytic subunits, IKKalpha and IKKbeta, and this recruitment appears to be an essential mechanism by which Tax stimulates the activity of IKK.", "output": {"entities": {"gene": [{"text": "Tax", "start": 4, "end": 7}, {"text": "IKKgamma", "start": 8, "end": 16}, {"text": "Tax", "start": 47, "end": 50}, {"text": "IKK catalytic subunits", "start": 58, "end": 80}, {"text": "IKKalpha", "start": 82, "end": 90}, {"text": "IKKbeta", "start": 95, "end": 102}, {"text": "Tax", "start": 171, "end": 174}, {"text": "IKK", "start": 202, "end": 205}]}}, "schema": []}
{"input": "An anchored AFLP-and retrotransposon-based map of diploid Avena.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, we identified a novel type of inhibitory domain in the N-terminal 60 amino acids of IRF-1 which strongly inhibits its transcriptional activity.", "output": {"entities": {"gene": [{"text": "IRF-1", "start": 97, "end": 102}]}}, "schema": []}
{"input": "Simultaneous determination of theophylline and its metabolites by HPLC] A high performance liquid chromatography (HPLC) method has been developed for the simultaneous determination of theophylline and its metabolites, with caffeine and its metabolites.", "output": {"entities": {}}, "schema": []}
{"input": "Ten males performed both test conditions and oxygen uptake VO2, heart rate, minute ventilation VE, perceived exertion and spinal shrinkage were recorded.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSION: SPT is more useful than WST in differentiating patients predisposed to aspiration.", "output": {"entities": {}}, "schema": []}
{"input": "Studied groups were (1) untreated control, n = 12; (2) FK-1, n = 8; (3) FK-3, n = 8.", "output": {"entities": {}}, "schema": []}
{"input": "DNA binding and glutathione S-transferase pull-down assays demonstrate that binding requires Elk-1 (1-212) but not the C-terminal transactivation domain.", "output": {"entities": {"gene": [{"text": "glutathione S-transferase", "start": 16, "end": 41}, {"text": "Elk-1 (1-212)", "start": 93, "end": 106}]}}, "schema": []}
{"input": "Unexpectedly, ALK7 signaling produced a remarkable change in cell morphology characterized by cell flattening and elaboration of blunt, short cell processes.", "output": {"entities": {"gene": [{"text": "ALK7", "start": 14, "end": 18}]}}, "schema": []}
{"input": "The swa2-1 allele recovered from the original screen carries a point mutation in its tetratricopeptide repeat (TPR) domain, a motif not found in auxilin but known in other proteins to mediate interaction with heat-shock proteins.", "output": {"entities": {"gene": [{"text": "swa2-1 allele", "start": 4, "end": 17}, {"text": "auxilin", "start": 145, "end": 152}, {"text": "heat-shock proteins", "start": 209, "end": 228}]}}, "schema": []}
{"input": "In slightly older embryos, the expression was skewed to one side of the embryo and by E6. 5, at the onset of gastrulation, expression was seen in the epiblast, visceral endoderm, nascent mesoderm, and the primitive streak.", "output": {"entities": {}}, "schema": []}
{"input": "The authors proposed that the highly convergent inputs to the entorhinal cortex indicate this region may be particularly important for selecting or compressing information.", "output": {"entities": {}}, "schema": []}
{"input": "Influence of oil emulsions and diphenyl on post-harvest physiconutritional changes in Kagzi limes (Citrus aurantifolia) was studied.", "output": {"entities": {}}, "schema": []}
{"input": "Detailed analysis of alpha1, 3GT transcripts revealed two major alternative splicing patterns in the 5'-untranslated region (5'-UTR) and evidence for minor splicing activity that occurs in a tissue-specific manner.", "output": {"entities": {"gene": [{"text": "alpha1, 3GT transcripts", "start": 21, "end": 44}]}}, "schema": []}
{"input": "A thermal Kubo-Martin-Schwinger condition arises due to the coupling of a computer to a strong periodic source, namely, the daily and weekly usage patterns of the system.", "output": {"entities": {}}, "schema": []}
{"input": "The non-homologous sequences in the 5' untranslated regions might be acquired at or after transcription during retrotransposition of the ATLN elements.", "output": {"entities": {}}, "schema": []}
{"input": "The time course of RNA1 replication and RNA3 synthesis in induced yeast paralleled that in yeast transfected with natural FHV virion RNA.", "output": {"entities": {"gene": [{"text": "RNA1", "start": 19, "end": 23}, {"text": "RNA3", "start": 40, "end": 44}]}}, "schema": []}
{"input": "The transcription and alternative splicing of human ORL1 and GAIP are cell-type specific.", "output": {"entities": {"gene": [{"text": "human ORL1", "start": 46, "end": 56}, {"text": "GAIP", "start": 61, "end": 65}]}}, "schema": []}
{"input": "The extraction was subsequently rated as' easy' or' difficult'. Taking Pell-Gregory class C as a predictor of a' difficult' extraction, specificity was 88% but sensitivity was low at 15%.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, our results show that ERKs and PI3Ks can synergise to convert ectoderm into mesoderm.", "output": {"entities": {"gene": [{"text": "ERKs", "start": 35, "end": 39}, {"text": "PI3Ks", "start": 44, "end": 49}]}}, "schema": []}
{"input": "Nevertheless, protein kinase A stimulation induces CREMalpha to activate the complex native promoter in the phosphoenolpyruvate carboxykinase (PEPCK) gene.", "output": {"entities": {"gene": [{"text": "protein kinase A", "start": 14, "end": 30}, {"text": "CREMalpha", "start": 51, "end": 60}, {"text": "phosphoenolpyruvate carboxykinase", "start": 108, "end": 141}, {"text": "PEPCK", "start": 143, "end": 148}]}}, "schema": []}
{"input": "Another putative HNF3 site in close apposition to a NF1/CTF site was localized upstream of the silencer-like element.", "output": {"entities": {"gene": [{"text": "HNF3 site", "start": 17, "end": 26}, {"text": "NF1", "start": 52, "end": 55}, {"text": "CTF", "start": 56, "end": 59}]}}, "schema": []}
{"input": "A recently reported new member of the Vav family proteins, Vav3 has been identified as a Ros receptor protein tyrosine kinase (RPTK) interacting protein by yeast two-hybrid screening.", "output": {"entities": {"gene": [{"text": "Vav family proteins", "start": 38, "end": 57}, {"text": "Vav3", "start": 59, "end": 63}, {"text": "Ros receptor protein tyrosine kinase", "start": 89, "end": 125}, {"text": "RPTK", "start": 127, "end": 131}]}}, "schema": []}
{"input": "Subsequently, we show that the reexpression of the r-PTPeta gene in highly malignant rat thyroid cells transformed by retroviruses carrying the v-mos and v-ras-Ki oncogenes suppresses their malignant phenotype.", "output": {"entities": {"gene": [{"text": "r-PTPeta gene", "start": 51, "end": 64}, {"text": "v-mos", "start": 144, "end": 149}, {"text": "v-ras-Ki oncogenes", "start": 154, "end": 172}]}}, "schema": []}
{"input": "Induced expression of Rnd3 is associated with transformation of polarized epithelial cells by the Raf-MEK-extracellular signal-regulated kinase pathway.", "output": {"entities": {"gene": [{"text": "Rnd3", "start": 22, "end": 26}, {"text": "Raf", "start": 98, "end": 101}, {"text": "MEK", "start": 102, "end": 105}]}}, "schema": []}
{"input": "The activity of the transcription factor CREB is regulated by extracellular stimuli that result in its phosphorylation at a critical serine residue, Ser133.", "output": {"entities": {"gene": [{"text": "transcription factor CREB", "start": 20, "end": 45}]}}, "schema": []}
{"input": "When 10 fields were analysed, a strong relationship was found between the presence of bacteria on Gram staining and the final diagnosis of VAP (for PSB and PTC respectively: sensitivity 74 and 81%, specificity 94 and 100%, positive predictive value 91 and 100%, negative predictive value 82 and 88%).", "output": {"entities": {}}, "schema": []}
{"input": "Tranilast in the Therapy of Coronary Artery Disease.", "output": {"entities": {}}, "schema": []}
{"input": "This study is a further and more extensive validation of the clinician rated NIMH-LCM-p.", "output": {"entities": {}}, "schema": []}
{"input": "The Aie1 locus was mapped to mouse chromosome 7A2-A3 by fluorescent in situ hybridization.", "output": {"entities": {"gene": [{"text": "Aie1 locus", "start": 4, "end": 14}]}}, "schema": []}
{"input": "Psychiatric disorders in children and adolescents carry considerable morbidity, impede development, and carry a significant mortality by suicide.", "output": {"entities": {}}, "schema": []}
{"input": "Thyrotoxicosis due to amiodarone is difficult to treat and is further complicated by the pro-arrhythmic potential of thyrotoxicosis and the fading antiarrhythmic effect after amiodarone withdrawal.", "output": {"entities": {}}, "schema": []}
{"input": "Chaperones/HSPs thus play important roles within cell cycle processes.", "output": {"entities": {"gene": [{"text": "HSPs", "start": 11, "end": 15}]}}, "schema": []}
{"input": "This study allows us to draw conclusions about the identity of proteins required for the development of the nervous system in Drosophila and provides an example of a molecular approach to characterize en masse transposon-tagged mutations identified in genetic screens.", "output": {"entities": {}}, "schema": []}
{"input": "Children with ADD showed an attenuated frontal CNV-1 amplitude and a trend towards increased CNV-1 and CNV-2 occipital amplitudes.", "output": {"entities": {}}, "schema": []}
{"input": "Where UMDNJ is headed.", "output": {"entities": {}}, "schema": []}
{"input": "Overexpression of c-Myc in serum-starved human or mouse embryonic cells leads to apoptosis which is significantly reduced in the presence of growth factor-containing serum. c-Myc-induced apoptosis appears to be deficient in bax-null as compared with bax-wild-type mouse embryonic fibroblasts.", "output": {"entities": {"gene": [{"text": "c-Myc", "start": 18, "end": 23}, {"text": "c-Myc", "start": 173, "end": 178}, {"text": "bax", "start": 224, "end": 227}, {"text": "bax", "start": 250, "end": 253}]}}, "schema": []}
{"input": "METHODS: T2 *-weighted, three-dimensional gradient-echo images were acquired by exploiting the magnetic susceptibility difference between oxygenated and deoxygenated hemoglobin in the vasculature and microvasculature.", "output": {"entities": {"gene": [{"text": "hemoglobin", "start": 166, "end": 176}]}}, "schema": []}
{"input": "In the COPD patients, the variability of Delta-inst Rrs (30%) was greater than that of FOT Rrs (21%).", "output": {"entities": {}}, "schema": []}
{"input": "Thus, Pet111p could play dual roles in both membrane localization and regulation of Cox2p synthesis within mitochondria.", "output": {"entities": {"gene": [{"text": "Pet111p", "start": 6, "end": 13}, {"text": "Cox2p", "start": 84, "end": 89}]}}, "schema": []}
{"input": "The determination of the double bounds in blood serum lipids by titration with ozone: the pathophysiology and diagnostic significance] In this article the method of definition of double binders in lipids of blood serum in patients with different diseases basically atherosclerosis and ischemic heart disease, with use titration by ozone is given.", "output": {"entities": {}}, "schema": []}
{"input": "Ang II-induced fibronectin mRNA was not affected by PKC inhibitors or PKC depletion, whereas specific inhibition of EGF-R function by a dominant negative EGF-R mutant and tyrphostin AG1478 abolished induction of fibronectin mRNA.", "output": {"entities": {"gene": [{"text": "Ang II", "start": 0, "end": 6}, {"text": "fibronectin", "start": 15, "end": 26}, {"text": "PKC", "start": 52, "end": 55}, {"text": "PKC", "start": 70, "end": 73}, {"text": "EGF-R", "start": 116, "end": 121}, {"text": "dominant negative EGF-R mutant", "start": 136, "end": 166}, {"text": "fibronectin mRNA", "start": 212, "end": 228}]}}, "schema": []}
{"input": "Acoust.", "output": {"entities": {}}, "schema": []}
{"input": "Video images of the nostrils were captured and then analyzed for area, perimeter, centroid, principal axis, moments about the major and minor axes (I11, I22), anisometry, bulkiness, lateral offset, internostril angle, and rotational angle.", "output": {"entities": {}}, "schema": []}
{"input": "Young fish (Oreochromis mossambicus) were exposed to microgravity (micro g) for 9 to 10 days during space missions STS-55 and STS-84, or to hypergravity (hg) for 9 days.", "output": {"entities": {}}, "schema": []}
{"input": "S6K2 is highly homologous to S6K1 in the core kinase and linker regulatory domains but differs from S6K1 in the N-and C-terminal regions and is differently localized primarily to the nucleus because of a C-terminal nuclear localization signal unique to S6K2.", "output": {"entities": {"gene": [{"text": "S6K2", "start": 0, "end": 4}, {"text": "S6K1", "start": 29, "end": 33}, {"text": "S6K1", "start": 100, "end": 104}, {"text": "S6K2", "start": 253, "end": 257}]}}, "schema": []}
{"input": "Pretreatment of cells with the mitogen-activated protein-extracellular signal-regulated kinase kinase (MEK) inhibitor U0126 inhibited S6K2 activation to a greater extent than S6K1.", "output": {"entities": {"gene": [{"text": "mitogen-activated protein-extracellular signal-regulated kinase kinase", "start": 31, "end": 101}, {"text": "MEK", "start": 103, "end": 106}, {"text": "S6K2", "start": 134, "end": 138}, {"text": "S6K1", "start": 175, "end": 179}]}}, "schema": []}
{"input": "T cells express two isoforms of S6k1: a 70 kDa cytoplasmic kinase and an 85 kDa isoform that has a classic nuclear localisation.", "output": {"entities": {"gene": [{"text": "S6k1", "start": 32, "end": 36}]}}, "schema": []}
{"input": "Ketanserin, a hypotensive drug with 5-HT2 receptor antagonism, when administered by topical infusion of a 0. 25% w/v solution by corneal and scleral applications, was found to lower intraocular pressure with four times more activity than its metabolite, ketanserinol.", "output": {"entities": {"gene": [{"text": "5-HT2 receptor", "start": 36, "end": 50}]}}, "schema": []}
{"input": "A prospectively gated 2D axial sequence with velocity encoding in the craniocaudal direction in the cervical region was set at a velocity of +/-10 cm/s.", "output": {"entities": {}}, "schema": []}
{"input": "It was subsequently shown that Tip60 had histone acetyltransferase (HAT) activity.", "output": {"entities": {"gene": [{"text": "Tip60", "start": 31, "end": 36}, {"text": "histone acetyltransferase", "start": 41, "end": 66}, {"text": "HAT", "start": 68, "end": 71}]}}, "schema": []}
{"input": "Our data show that multiple MLSN1 transcripts, both constitutively expressed and inducible, are present in cultured pigmented melanoma cells, and suggest that MLSN1 expression can be regulated at the level of both transcription and mRNA processing.", "output": {"entities": {"gene": [{"text": "MLSN1 transcripts", "start": 28, "end": 45}, {"text": "MLSN1", "start": 159, "end": 164}]}}, "schema": []}
{"input": "These results also suggest the involvement of additional elements in the UPR.", "output": {"entities": {}}, "schema": []}
{"input": "We show that in contrast to SRC1, direct binding of CBP to the estrogen receptor is weak, suggesting that SRC1 functions primarily as an adaptor to recruit CBP and p300.", "output": {"entities": {"gene": [{"text": "SRC1", "start": 28, "end": 32}, {"text": "CBP", "start": 52, "end": 55}, {"text": "estrogen receptor", "start": 63, "end": 80}, {"text": "SRC1", "start": 106, "end": 110}, {"text": "CBP", "start": 156, "end": 159}, {"text": "p300", "start": 164, "end": 168}]}}, "schema": []}
{"input": "Remarkably, a construct corresponding to residues 631 to 970, which contains only the LXXLL motifs and the AD1 region of SRC1, retained strong coactivator activity in our assays.", "output": {"entities": {"gene": [{"text": "SRC1", "start": 121, "end": 125}]}}, "schema": []}
{"input": "Since MEK acts as a cytoplasmic anchor for the ERKs, the lack of a MEK interaction resulted in the aberrant nuclear localization of ERK2-Delta19-25 mutants in serum-starved cells.", "output": {"entities": {"gene": [{"text": "MEK", "start": 6, "end": 9}, {"text": "ERKs", "start": 47, "end": 51}, {"text": "MEK", "start": 67, "end": 70}, {"text": "ERK2", "start": 132, "end": 136}, {"text": "Delta19-25", "start": 137, "end": 147}]}}, "schema": []}
{"input": "Pmt2 is a member of a six-protein family in yeast that catalyzes the first step in O mannosylation of target proteins.", "output": {"entities": {"gene": [{"text": "Pmt2", "start": 0, "end": 4}]}}, "schema": []}
{"input": "Of the 21 quadrants positive in the controls, 17 were correlated with previously detected jaw pathoses.", "output": {"entities": {}}, "schema": []}
{"input": "Four cases of synovial chondromatosis are presented.", "output": {"entities": {}}, "schema": []}
{"input": "Previous studies have shown that the pro-inflammatory cytokines tumor necrosis factor alpha and interferon gamma reduce the expression of the cystic fibrosis transmembrane conductance regulator (CFTR) gene (CFTR) in HT-29 and T84 cells by acting post-transcriptionally.", "output": {"entities": {"gene": [{"text": "tumor necrosis factor alpha", "start": 64, "end": 91}, {"text": "interferon gamma", "start": 96, "end": 112}, {"text": "cystic fibrosis transmembrane conductance regulator", "start": 142, "end": 193}, {"text": "CFTR", "start": 195, "end": 199}, {"text": "CFTR", "start": 207, "end": 211}]}}, "schema": []}
{"input": "Regulation of RhoA is required to maintain adhesion in stationary cells, but is also critical for cell spreading and migration [3].", "output": {"entities": {"gene": [{"text": "RhoA", "start": 14, "end": 18}]}}, "schema": []}
{"input": "Here we show in mouse fibroblasts stably transformed by v-Src that mRNA and protein levels of p21 (WAF1/CIP1), cyclin D1, and cyclin E are elevated.", "output": {"entities": {"gene": [{"text": "v-Src", "start": 56, "end": 61}, {"text": "p21", "start": 94, "end": 97}, {"text": "WAF1", "start": 99, "end": 103}, {"text": "CIP1", "start": 104, "end": 108}, {"text": "cyclin D1", "start": 111, "end": 120}, {"text": "cyclin E", "start": 126, "end": 134}]}}, "schema": []}
{"input": "ORFA and ccdA were constitutively cotranscribed as determined by primer extension analysis.", "output": {"entities": {"gene": [{"text": "ccdA", "start": 9, "end": 13}]}}, "schema": []}
{"input": "Mouse Impact is a paternally expressed gene encoding an evolutionarily conserved protein of unknown function.", "output": {"entities": {"gene": [{"text": "Mouse Impact", "start": 0, "end": 12}]}}, "schema": []}
{"input": "Coexpression studies indicate that insulin and PKB suppress transactivation by C/EBPbeta, but not C/EBPalpha, and that N-terminal transactivation domains in C/EBPbeta are required.", "output": {"entities": {"gene": [{"text": "insulin", "start": 35, "end": 42}, {"text": "PKB", "start": 47, "end": 50}, {"text": "C/EBPbeta", "start": 79, "end": 88}, {"text": "C/EBPalpha", "start": 98, "end": 108}, {"text": "C/EBPbeta", "start": 157, "end": 166}]}}, "schema": []}
{"input": "Among eight graminaceous species tested, Ids3 expression was observed only in Fe-deficient roots of H. vulgare and Secale cereale. which not only secrete 2'-deoxymugineic acid (DMA), but also mugineic acid (MA) and 3-epihydroxymugineic acid (epiHMA, H. vulgare), and 3-hydroxymugineic acid (HMA, S. cereale).", "output": {"entities": {"gene": [{"text": "Ids3", "start": 41, "end": 45}]}}, "schema": []}
{"input": "In contrast, high COUP-TFI expression impeded the neuronal differentiation of P19 cells induced with RA, resulting in cell cultures lacking neurons.", "output": {"entities": {"gene": [{"text": "COUP-TFI", "start": 18, "end": 26}]}}, "schema": []}
{"input": "Because PET is also useful for the pretreatment and follow-up evaluation, the use of stereotactic PET in these patients can enable an accurate comparison of PET-based metabolic data with MR-based anatomical data.", "output": {"entities": {}}, "schema": []}
{"input": "Therefore, in our in vitro model, the localization of the mutation in the K-ras gene predisposes to a different level of aggressiveness in the transforming phenotype.", "output": {"entities": {"gene": [{"text": "K-ras gene", "start": 74, "end": 84}]}}, "schema": []}
{"input": "Here, we describe the isolation of MdPin1, a Pin1 homologue from the plant species apple (Malus domestica) and show that it has the same phosphorylation-specific substrate specificity and can be inhibited by juglone in vitro, as is the case for Pin1.", "output": {"entities": {"gene": [{"text": "MdPin1", "start": 35, "end": 41}, {"text": "Pin1", "start": 45, "end": 49}, {"text": "Pin1", "start": 245, "end": 249}]}}, "schema": []}
{"input": "These and other data presented suggest that TAg' re-models' host cell transcription factors that are used early in viral infection, and thereby mimics an event that naturally occurs during transformation.", "output": {"entities": {"gene": [{"text": "TAg", "start": 44, "end": 47}]}}, "schema": []}
{"input": "This sensitivity analysis showed that the practical limits of the accuracy of the used screening test jeopardize the estimation of the true herd prevalence within reasonable confidence limits, because the within-herd PTB true prevalence was low. For this reason we augmented the herd specificity for herds with larger adult herd size (> 5).", "output": {"entities": {}}, "schema": []}
{"input": "ORFK10. 5 encodes a protein, latency-associated nuclear antigen 2 (LANA2), which is expressed in KSHV-infected hematopoietic tissues, including PEL and CD but not KS lesions.", "output": {"entities": {"gene": [{"text": "ORFK10. 5", "start": 0, "end": 9}, {"text": "latency-associated nuclear antigen 2", "start": 29, "end": 65}, {"text": "LANA2", "start": 67, "end": 72}]}}, "schema": []}
{"input": "In Xenopus, BMPs act as epidermal inducers and also as negative regulators of neurogenesis.", "output": {"entities": {"gene": [{"text": "BMPs", "start": 12, "end": 16}]}}, "schema": []}
{"input": "Presently four unique variants carrying distinct GAF sequences in the N-terminal region have been identified.", "output": {"entities": {"gene": [{"text": "GAF sequences", "start": 49, "end": 62}]}}, "schema": []}
{"input": "Genomic organization of the human phosphodiesterase PDE11A gene.", "output": {"entities": {"gene": [{"text": "phosphodiesterase PDE11A gene", "start": 34, "end": 63}]}}, "schema": []}
{"input": "The present findings revealed that the rib-2 protein was a unique alpha1, 4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate.", "output": {"entities": {"gene": [{"text": "rib-2 protein", "start": 39, "end": 52}, {"text": "alpha1, 4-N-acetylglucosaminyltransferase", "start": 66, "end": 107}]}}, "schema": []}
{"input": "Inhibition of the Mek/Erk pathway in Rat1/ras cells, using the Mek inhibitor, PD98059, resulted in complete cytoskeletal recovery, indistinguishable from that induced by HR12.", "output": {"entities": {"gene": [{"text": "Mek", "start": 18, "end": 21}, {"text": "Erk", "start": 22, "end": 25}, {"text": "ras", "start": 42, "end": 45}, {"text": "Mek", "start": 63, "end": 66}]}}, "schema": []}
{"input": "The transcription factor CHOP/GADD153 gene is induced by cellular stress and is involved in mediating apoptosis.", "output": {"entities": {"gene": [{"text": "CHOP", "start": 25, "end": 29}, {"text": "GADD153", "start": 30, "end": 37}]}}, "schema": []}
{"input": "Addition of synthetic tyrosine-phosphorylated peptides derived from betac cytoplasmic tyrosines prior to GM-CSF stimulation inhibited the in vitro activation of STAT5.", "output": {"entities": {"gene": [{"text": "GM-CSF", "start": 105, "end": 111}, {"text": "STAT5", "start": 161, "end": 166}]}}, "schema": []}
{"input": "MAIN OUTCOME MEASURES: Percentage change in the apnea-hypopnea index (AHI; apnea events + hypopnea events per hour of sleep) and odds of developing moderate-to-severe SDB (defined by an AHI > or = 15 events per hour of sleep), with respect to change in weight.", "output": {"entities": {}}, "schema": []}
{"input": "Paraneoplastic rheumatic syndromes.", "output": {"entities": {}}, "schema": []}
{"input": "This article reviews recent information on the frequency, characteristics, and possible pathogenic mechanisms of the vasculitides occurring in patients with the main connective tissue diseases.", "output": {"entities": {}}, "schema": []}
{"input": "Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain.", "output": {"entities": {"gene": [{"text": "Tec kinase", "start": 0, "end": 10}, {"text": "phosphatidylinositol 3-kinase", "start": 48, "end": 77}, {"text": "Tec pleckstrin homology domain", "start": 86, "end": 116}]}}, "schema": []}
{"input": "Current evidence for this type of DNA supercoiling-dependent transcriptional coupling, based largely on the in vivo activities of promoters contained in engineered DNA constructs, suggests that the transcription complex must be physically hindered to generate DNA supercoils and to prevent their diffusion throughout the DNA duplex.", "output": {"entities": {}}, "schema": []}
{"input": "The structure of the free SH2 domain has been compared to that of the SH2 complexed with a doubly phosphorylated peptide derived from polyomavirus middle T antigen (MT).", "output": {"entities": {"gene": [{"text": "SH2 domain", "start": 26, "end": 36}, {"text": "SH2", "start": 70, "end": 73}, {"text": "polyomavirus middle T antigen", "start": 134, "end": 163}, {"text": "MT", "start": 165, "end": 167}]}}, "schema": []}
{"input": "We have identified three binding sites for protein complexes: a palindrome, a direct repeat, and a C + T sequence that corresponds to seven GAGA motifs on the transcribed strand.", "output": {"entities": {}}, "schema": []}
{"input": "Copyright 2000 Academic Press.", "output": {"entities": {}}, "schema": []}
{"input": "Patients underwent pretreatment cystoscopy and detailed tumor mapping, and were treated with 75 mg./m. 2 cisplatin on day 1 and 1 gm./m. 2 daily, 5-fluorouracil on days 1 to 4 and definitive radiotherapy.", "output": {"entities": {}}, "schema": []}
{"input": "All 9 untreated patients underwent laparoscopy, which identified 3 intra-abdominal, 3 vanished and 2 peeping testes, and 1 atrophic testis in the inguinal canal.", "output": {"entities": {}}, "schema": []}
{"input": "This philosophy was instituted for the compound RP 73401, a specific phosphodiesterase IV inhibitor, that was being developed simultaneously for delivery by both oral and pulmonary routes of administration.", "output": {"entities": {"gene": [{"text": "phosphodiesterase IV", "start": 69, "end": 89}]}}, "schema": []}
{"input": "Increased levels of anticardiolipin immunoglobulin G may also cause bleeding.", "output": {"entities": {"gene": [{"text": "anticardiolipin immunoglobulin G", "start": 20, "end": 52}]}}, "schema": []}
{"input": "RESULTS: Prevalence of obesity (BMI SDS > 2. 0) was < 2% at diagnosis, but increased to 16% at 3y.", "output": {"entities": {}}, "schema": []}
{"input": "One of the sequelae of the antiphospholipid-antibodies is an impaired uteroplacental circulation.", "output": {"entities": {}}, "schema": []}
{"input": "Bupropion to aid smoking cessation.", "output": {"entities": {}}, "schema": []}
{"input": "Using a natural dominant negative for AP-1 transcriptional activity in ROS 17/2. 8 cells, we then showed that AP-1 transcription factors mediated TGF-beta1-and BMP-2-regulated expression of the (alpha1) collagen I gene as well as TGF-beta1-regulated expression of the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor.", "output": {"entities": {"gene": [{"text": "AP-1", "start": 38, "end": 42}, {"text": "AP-1 transcription factors", "start": 110, "end": 136}, {"text": "TGF-beta1", "start": 146, "end": 155}, {"text": "BMP-2", "start": 160, "end": 165}, {"text": "(alpha1) collagen I gene", "start": 194, "end": 218}, {"text": "TGF-beta1", "start": 230, "end": 239}, {"text": "parathyroid hormone", "start": 268, "end": 287}, {"text": "PTH", "start": 289, "end": 292}, {"text": "PTH-related peptide (PTHrP) receptor", "start": 294, "end": 330}]}}, "schema": []}
{"input": "PM 12 or 18 mg/kg daily plus a standard dose of SB for 21 days was statistically more effective than SB in producing a final cure for patients with VL in Bihar, India.", "output": {"entities": {}}, "schema": []}
{"input": "There were significant differences (p < 0. 05) between the fracture and nonfracture groups in the total femur BMD (13%), trabecular BMD in the distal radius (4%), and the fractal dimension in the radiographs (FD2) (3%).", "output": {"entities": {}}, "schema": []}
{"input": "BACKGROUND: The aim of this study was to determine and compare interleukin-6 (IL-6) levels in gingival crevicular fluid (GCF) and clinical periodontal findings in patients with rheumatoid arthritis (RA) and adult periodontitis (AP).", "output": {"entities": {"gene": [{"text": "interleukin-6", "start": 63, "end": 76}, {"text": "IL-6", "start": 78, "end": 82}]}}, "schema": []}
{"input": "In a prospective, multicentre trial the efficacy of an Vitex agnus castus L extract Ze 440 was investigated in 50 patients with pre-menstrual syndrome (PMS).", "output": {"entities": {}}, "schema": []}
{"input": "Studies are necessary to assess the source of contamination and potential role of MRSA-contaminated milk in the transmission of MRSA to neonates.", "output": {"entities": {}}, "schema": []}
{"input": "Depending on treatment exposures, this at-risk population may experience life-threatening late effects, such as cirrhosis secondary to hepatitis C or late-onset anthracycline-induced cardiomyopathy, or life-changing late effects, such as cognitive dysfunction.", "output": {"entities": {}}, "schema": []}
{"input": "The presence of locus-specific residues throughout the entire promoter region strongly suggests that the various HLA class I loci are differentially regulated.", "output": {"entities": {"gene": [{"text": "HLA class I loci", "start": 113, "end": 129}]}}, "schema": []}
{"input": "Because the number of parameters required by a Volterra series grows rapidly with both the length of its memory and the order of its nonlinearity, methods for identifying these models from measurements of input/output data are limited to low-order systems with relatively short memories.", "output": {"entities": {}}, "schema": []}
{"input": "The standard method for calculating the composite score on the S-B IV excludes subtests with a raw score of 0, which overestimates cognitive functioning in young biologically high risk children.", "output": {"entities": {}}, "schema": []}
{"input": "NiCl (2)-induced MCP-1 synthesis required activation of NF-kappaB since mutation of NF-kappaB-binding sites in the promoter resulted in complete loss of inducible promoter activity.", "output": {"entities": {"gene": [{"text": "MCP-1", "start": 17, "end": 22}, {"text": "NF-kappaB", "start": 56, "end": 65}, {"text": "NF-kappaB-binding sites", "start": 84, "end": 107}]}}, "schema": []}
{"input": "Engagement of human CD2 by mitogenic pairs of anti-CD2 mAb induces tyrosine phosphorylation of a number of intracellular proteins including a 120 kDa phosphoprotein that we identify as the proto-oncogene c-Cbl.", "output": {"entities": {"gene": [{"text": "human CD2", "start": 14, "end": 23}, {"text": "anti-CD2 mAb", "start": 46, "end": 58}, {"text": "proto-oncogene c-Cbl", "start": 189, "end": 209}]}}, "schema": []}
{"input": "Validity of NIR spectroscopy for quantitatively measuring muscle oxidative metabolic rate in exercise.", "output": {"entities": {}}, "schema": []}
{"input": "Previous studies have demonstrated that tissue-restricted transcription factors including PU. 1 and PU. 1 interaction partner (PIP) function synergistically with c-Fos plus c-Jun to stimulate the kappaE3'-enhancer in 3T3 cells.", "output": {"entities": {"gene": [{"text": "PU. 1", "start": 90, "end": 95}, {"text": "PU. 1 interaction partner", "start": 100, "end": 125}, {"text": "PIP", "start": 127, "end": 130}, {"text": "c-Fos", "start": 162, "end": 167}, {"text": "c-Jun", "start": 173, "end": 178}, {"text": "kappaE3'-enhancer", "start": 196, "end": 213}]}}, "schema": []}
{"input": "The murine int-6 locus, identified as a frequent integration site of mouse mammary tumor viruses, encodes the 48-kDa eIF3e subunit of translation initiation factor eIF3.", "output": {"entities": {"gene": [{"text": "murine int-6 locus", "start": 4, "end": 22}, {"text": "48-kDa eIF3e subunit of translation initiation factor eIF3", "start": 110, "end": 168}]}}, "schema": []}
{"input": "An int6 deletion (int6Delta) mutant was viable but grew slowly in minimal medium.", "output": {"entities": {"gene": [{"text": "int6 deletion", "start": 3, "end": 16}, {"text": "int6Delta", "start": 18, "end": 27}]}}, "schema": []}
{"input": "We produced transgenic plants expressing the antisense Arabidopsis HD (AtHD1) gene.", "output": {"entities": {"gene": [{"text": "antisense Arabidopsis HD", "start": 45, "end": 69}, {"text": "AtHD1", "start": 71, "end": 76}]}}, "schema": []}
{"input": "Four transcription initiation sites have been identified by full-length RNA ligase-mediated rapid amplification of cDNA ends (RLM-RACE) between-61 and-32 bp from the translation initiation codon. Reverse transcription-PCR analysis revealed that PFK-A, PFK-B and PFK-C genes were expressed, in all mouse tissues tested, at varying levels.", "output": {"entities": {"gene": [{"text": "RNA ligase", "start": 72, "end": 82}, {"text": "PFK-A", "start": 245, "end": 250}, {"text": "PFK-B", "start": 252, "end": 257}, {"text": "PFK-C genes", "start": 262, "end": 273}]}}, "schema": []}
{"input": "PFK-A mRNA was more abundantly expressed in all tissues than were the PFK-B and PFK-C genes.", "output": {"entities": {"gene": [{"text": "PFK-A", "start": 0, "end": 5}, {"text": "PFK-B", "start": 70, "end": 75}, {"text": "PFK-C genes", "start": 80, "end": 91}]}}, "schema": []}
{"input": "We used the Toshiba IIDR system, which is composed of an X-ray TV system and a digital image managing circuit.", "output": {"entities": {}}, "schema": []}
{"input": "In whole sardine, domoic acid was detected in levels exceeding sometimes the regulatory limit.", "output": {"entities": {}}, "schema": []}
{"input": "Closeup: a resource for nurses who smoke.", "output": {"entities": {}}, "schema": []}
{"input": "[18F] (+)-4-fluorobenzyltrozamicol (FBT), which selectively binds to the vesicular acetylcholine transporter in the presynaptic cholinergic neuron, has previously been shown to be a useful ligand for the study of cholinergic terminal density in the basal ganglia with PET.", "output": {"entities": {"gene": [{"text": "acetylcholine transporter", "start": 83, "end": 108}]}}, "schema": []}
{"input": "We demonstrate that the protein is a murine homologue of SAF-A which has been shown to bind selectively to MARs and is responsible for the satMa-binding activity in the chromatographic fractions.", "output": {"entities": {"gene": [{"text": "murine homologue of SAF-A", "start": 37, "end": 62}, {"text": "satMa", "start": 139, "end": 144}]}}, "schema": []}
{"input": "The molecular associations dictating INCENP behavior during mitosis are currently unknown.", "output": {"entities": {"gene": [{"text": "INCENP", "start": 37, "end": 43}]}}, "schema": []}
{"input": "Ang II significantly induced Ang2 mRNA accumulations without affecting Ang1 or Tie2 expression, which was inhibited by protein kinase C inhibitors and by intracellular Ca (2 +) chelating agents.", "output": {"entities": {"gene": [{"text": "Ang II", "start": 0, "end": 6}, {"text": "Ang2 mRNA", "start": 29, "end": 38}, {"text": "Ang1", "start": 71, "end": 75}, {"text": "Tie2", "start": 79, "end": 83}, {"text": "protein kinase C", "start": 119, "end": 135}]}}, "schema": []}
{"input": "Promoter analysis demonstrated that the sequence identical to consensus cAMP-responsive element (CRE) located at-481 of the SMemb promoter was critical for Hex responsiveness.", "output": {"entities": {"gene": [{"text": "SMemb promoter", "start": 124, "end": 138}, {"text": "Hex", "start": 156, "end": 159}]}}, "schema": []}
{"input": "LH/CG receptor activation of ARNO is not mediated by activation of phosphatidylinositol 3-kinase (PI 3-kinase) or by G protein beta gamma subunits.", "output": {"entities": {"gene": [{"text": "LH/CG receptor", "start": 0, "end": 14}, {"text": "ARNO", "start": 29, "end": 33}, {"text": "phosphatidylinositol 3-kinase", "start": 67, "end": 96}, {"text": "PI 3-kinase", "start": 98, "end": 109}, {"text": "G protein beta gamma subunits", "start": 117, "end": 146}]}}, "schema": []}
{"input": "Deletion analysis showed that the-321/+ 41 sequence was sufficient for both the constitutive promoter activity and auto-activation and electrophoretic mobility shift assays identified the interaction of C/EBPs and Sp1 to this region.", "output": {"entities": {"gene": [{"text": "C/EBPs", "start": 203, "end": 209}, {"text": "Sp1", "start": 214, "end": 217}]}}, "schema": []}
{"input": "Termination of induced VT on the first attempt was comparable with BV pacing (87. 4%) versus RV pacing (89. 6%).", "output": {"entities": {}}, "schema": []}
{"input": "We compare the results of this algorithm with the results obtained with two other algorithms, the optimal algorithm for monochannel nonoverlapping noise and the optimal algorithm for multichannel additive noise, and we show that in both cases improvement can be obtained.", "output": {"entities": {}}, "schema": []}
{"input": "Changes in stimulation levels over time in nucleus 22 cochlear implant users.", "output": {"entities": {}}, "schema": []}
{"input": "A marked decrease in the type 1 insulin-like growth factor (IGF) receptor (IGF-IR) occurs in prostate epithelial cells during transformation from the benign to the metastatic state.", "output": {"entities": {"gene": [{"text": "type 1 insulin-like growth factor (IGF) receptor", "start": 25, "end": 73}, {"text": "IGF-IR", "start": 75, "end": 81}]}}, "schema": []}
{"input": "The P69 cell line was derived by immortalization of human primary prostate epithelial cells with simian virus-40 T antigen and is rarely tumorigenic.", "output": {"entities": {"gene": [{"text": "simian virus-40 T antigen", "start": 97, "end": 122}]}}, "schema": []}
{"input": "We determined whether the human StAR promoter is responsive to sterol regulatory element-binding proteins (SREBPs).", "output": {"entities": {"gene": [{"text": "human StAR promoter", "start": 26, "end": 45}, {"text": "sterol regulatory element-binding proteins", "start": 63, "end": 105}, {"text": "SREBPs", "start": 107, "end": 113}]}}, "schema": []}
{"input": "Expression of SREBP-1a stimulated StAR promoter activity in the context of COS-1 cells and human granulosa-lutein cells.", "output": {"entities": {"gene": [{"text": "SREBP-1a", "start": 14, "end": 22}, {"text": "StAR promoter", "start": 34, "end": 47}]}}, "schema": []}
{"input": "Because the high-density lipoprotein receptor (HDL-R) is a key element in cholesterol homeostasis and a potential therapeutic target for hypercholesterolemic drugs, an understanding of HDL-R regulation is essential.", "output": {"entities": {"gene": [{"text": "high-density lipoprotein receptor", "start": 12, "end": 45}, {"text": "HDL-R", "start": 47, "end": 52}, {"text": "HDL-R", "start": 185, "end": 190}]}}, "schema": []}
{"input": "IFN-stimulated gene factor-3 and STAT1 homodimers formed and bound an IFN-stimulated response element (ISRE) and gamma-activated sequence (GAS) element, respectively.", "output": {"entities": {"gene": [{"text": "IFN-stimulated gene factor-3", "start": 0, "end": 28}, {"text": "STAT1 homodimers", "start": 33, "end": 49}, {"text": "IFN-stimulated response element", "start": 70, "end": 101}, {"text": "ISRE", "start": 103, "end": 107}, {"text": "gamma-activated sequence", "start": 113, "end": 137}, {"text": "GAS", "start": 139, "end": 142}]}}, "schema": []}
{"input": "We have therefore studied the molecular mechanisms of TGF-beta1 action on thyroglobulin (TG) gene expression by focusing our attention on TGF-beta1 regulation of thyroid-specific transcription factors.", "output": {"entities": {"gene": [{"text": "TGF-beta1", "start": 54, "end": 63}, {"text": "thyroglobulin", "start": 74, "end": 87}, {"text": "TG", "start": 89, "end": 91}, {"text": "TGF-beta1", "start": 138, "end": 147}]}}, "schema": []}
{"input": "The epitope-protected lysine (K) was present in a 30-aa TPO fragment that, by N-terminal sequencing, was found to be K713.", "output": {"entities": {"gene": [{"text": "30-aa TPO fragment", "start": 50, "end": 68}]}}, "schema": []}
{"input": "To understand the molecular regulation of these genes in thyroid cells, the effect of thyroid transcription factor 1 (TTF-1) and the paired domain-containing protein 8 (Pax-8) on the transcriptional activity of the deiodinase promoters were studied.", "output": {"entities": {"gene": [{"text": "thyroid transcription factor 1", "start": 86, "end": 116}, {"text": "TTF-1", "start": 118, "end": 123}, {"text": "paired domain-containing protein 8", "start": 133, "end": 167}, {"text": "Pax-8", "start": 169, "end": 174}, {"text": "deiodinase promoters", "start": 215, "end": 235}]}}, "schema": []}
{"input": "Regional blood blow was measured by means of microspheres in predefined regions of the C6, T11, and L6 vertebrae.", "output": {"entities": {}}, "schema": []}
{"input": "Activation of transcription through the AP-1 site in Jurkat cells by JunD and/or Fra-2 was weak. c-Jun, JunB, and c-Fos activation was greater, although the level was still less than that with Tax.", "output": {"entities": {"gene": [{"text": "AP-1 site", "start": 40, "end": 49}, {"text": "JunD", "start": 69, "end": 73}, {"text": "Fra-2", "start": 81, "end": 86}, {"text": "c-Jun", "start": 97, "end": 102}, {"text": "JunB", "start": 104, "end": 108}, {"text": "c-Fos", "start": 114, "end": 119}, {"text": "Tax", "start": 193, "end": 196}]}}, "schema": []}
{"input": "The mechanism of ligand-activated estrogen receptor alpha (ERalpha)-dependent activation of gene expression through the SRE was determined by mutational analysis of the promoter, analysis of mitogen-activated protein kinase (MAPK) pathway activation by E2, and transforming growth factor alpha (TGF-alpha) as a positive control.", "output": {"entities": {"gene": [{"text": "estrogen receptor alpha", "start": 34, "end": 57}, {"text": "ERalpha", "start": 59, "end": 66}, {"text": "mitogen-activated protein kinase", "start": 191, "end": 223}, {"text": "MAPK", "start": 225, "end": 229}, {"text": "transforming growth factor alpha", "start": 261, "end": 293}, {"text": "TGF-alpha", "start": 295, "end": 304}]}}, "schema": []}
{"input": "CONCLUSIONS: Under current immunization practices, the authors estimate that nearly 13, 000 Asian and Pacific Islander children living in the United States today will become infected with HBV in the future, resulting in more than 600 liver carcinoma deaths.", "output": {"entities": {}}, "schema": []}
{"input": "We observed NP/NMP4/CIZ expression in osteocytes, osteoblasts, and chondrocytes in rat bone.", "output": {"entities": {"gene": [{"text": "NP", "start": 12, "end": 14}, {"text": "NMP4", "start": 15, "end": 19}, {"text": "CIZ", "start": 20, "end": 23}]}}, "schema": []}
{"input": "Chlamydia and cervical cancer: a real association?", "output": {"entities": {}}, "schema": []}
{"input": "A novel approach was developed for identifying transcription factor activities associated with NGF-activated, but not EGF-activated, signaling, using random oligonucleotide clones from a DNA recognition library to isolate specific DNA binding proteins from PC12 nuclear extracts.", "output": {"entities": {"gene": [{"text": "NGF", "start": 95, "end": 98}, {"text": "EGF", "start": 118, "end": 121}]}}, "schema": []}
{"input": "NGF elicits a more delayed and sustained ERK phosphorylation than EGF, consistent with previous reports.", "output": {"entities": {"gene": [{"text": "NGF", "start": 0, "end": 3}, {"text": "ERK", "start": 41, "end": 44}, {"text": "EGF", "start": 66, "end": 69}]}}, "schema": []}
{"input": "NGF, but not EGF, enhances the upper bands, corresponding to phosphorylated Fra-2.", "output": {"entities": {"gene": [{"text": "NGF", "start": 0, "end": 3}, {"text": "EGF", "start": 13, "end": 16}, {"text": "phosphorylated Fra-2", "start": 61, "end": 81}]}}, "schema": []}
{"input": "The actA gene is present as a single copy in the genome of A. chrysogenum; and its expression level, opposite to pcbC and cefEF cephalosporin biosynthetic genes, was steady during cephalosporin fermentation, showing a single 1. 4-kb transcript.", "output": {"entities": {"gene": [{"text": "actA gene", "start": 4, "end": 13}, {"text": "pcbC", "start": 113, "end": 117}, {"text": "cefEF cephalosporin biosynthetic genes", "start": 122, "end": 160}]}}, "schema": []}
{"input": "Adding 10 mmol SDS/l led to transient inhibition of acidification, metal solubilization and sulfur oxidation.", "output": {"entities": {}}, "schema": []}
{"input": "We have investigated the role of NGF in regulating gene transcription in PC12 and INS-1 cells, in order to define if there are NGF-regulated genes per se.", "output": {"entities": {"gene": [{"text": "NGF", "start": 33, "end": 36}, {"text": "NGF", "start": 127, "end": 130}]}}, "schema": []}
{"input": "Nine animals served as control animals, whereas 20 animals received a focal arachnoid scar at C1-C2, which was produced by placement of a kaolin-soaked fibrin sponge on the posterior surface of the spinal cord.", "output": {"entities": {"gene": [{"text": "fibrin", "start": 152, "end": 158}]}}, "schema": []}
{"input": "The Schistosoma mansoni homologue (SmSmad2) was overexpressed in bacteria as a Sj26-GST fusion protein and used to raise specific antibodies.", "output": {"entities": {"gene": [{"text": "Schistosoma mansoni homologue", "start": 4, "end": 33}, {"text": "SmSmad2", "start": 35, "end": 42}, {"text": "Sj26", "start": 79, "end": 83}, {"text": "GST", "start": 84, "end": 87}]}}, "schema": []}
{"input": "These data indicate that the SmSmad2 responds to the TGF-beta signals by interaction with receptor I, which phosphorylates it, whereupon it translocates into the nucleus presumably to regulate target gene transcription and consequently elicit a specific TGF-beta effect.", "output": {"entities": {"gene": [{"text": "SmSmad2", "start": 29, "end": 36}, {"text": "TGF-beta", "start": 53, "end": 61}, {"text": "receptor I", "start": 90, "end": 100}, {"text": "TGF-beta", "start": 254, "end": 262}]}}, "schema": []}
{"input": "Intact Flag-tagged protein products from all six were produced from genomic expression vectors, although the ORF40/41 transcript encoding a primase-helicase component proved to be spliced with a 127-bp intron.", "output": {"entities": {"gene": [{"text": "primase", "start": 140, "end": 147}, {"text": "helicase", "start": 148, "end": 156}]}}, "schema": []}
{"input": "Expression of the src homology 3 (SH3)-encoding, expressed in tumorigenic astrocytes (SETA) gene is associated with astrocyte transformation in culture and tumors in the adult brain.", "output": {"entities": {"gene": [{"text": "src homology 3", "start": 18, "end": 32}, {"text": "SH3", "start": 34, "end": 37}, {"text": "SETA", "start": 86, "end": 90}]}}, "schema": []}
{"input": "METHODS: One hundred fourteen consecutive patients (mean age 61 years) with focal pancreatic masses, detected on CT, underwent EUS-FNA by using a linear-array echoendoscope and 22-gauge needles.", "output": {"entities": {}}, "schema": []}
{"input": "METHODS: Thyroid status was measured at baseline (1990-93), through assessment of serum antibodies to thyroid peroxidase (TPO-Abs, positive: > 10 IU/ml), serum TSH levels, and when TSH was abnormal (< 0. 4 or > 4. 0 mU/l), serum thyroxin levels (T4).", "output": {"entities": {"gene": [{"text": "thyroid peroxidase", "start": 102, "end": 120}, {"text": "TPO-Abs", "start": 122, "end": 129}, {"text": "serum TSH", "start": 154, "end": 163}, {"text": "TSH", "start": 181, "end": 184}, {"text": "serum thyroxin", "start": 223, "end": 237}]}}, "schema": []}
{"input": "We suggest that ventriculopleural shunting should be considered as the preferred alternative to peritoneal drainage in children with intra-abdominal adhesions or with a history of recent peritoneal infection.", "output": {"entities": {}}, "schema": []}
{"input": "TBARS levels, oxygen-radical absorbing capacity assay and AFR release assessed by electron paramagnetic resonance (EPR) were used to explore the existence of oxidative stress in diabetes.", "output": {"entities": {}}, "schema": []}
{"input": "Long-range comparison of human and mouse SCL loci: localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences.", "output": {"entities": {"gene": [{"text": "human and mouse SCL loci", "start": 25, "end": 49}]}}, "schema": []}
{"input": "To account for this observation, other possible causes include increased CSF pulsation in children creating motion artifact, changes in arterial oxygen concentration intrinsic to propofol or related to the supplemental oxygen normally administered, or changes in CSF protein levels related to propofol binding to proteins for uptake into CSF.", "output": {"entities": {}}, "schema": []}
{"input": "The utilities measured in our study can be applied directly to quality-of-life determinations in clinical trials of adjuvant IFN alpha-2b to measure the net benefit of therapy.", "output": {"entities": {"gene": [{"text": "IFN alpha-2b", "start": 125, "end": 137}]}}, "schema": []}
{"input": "Serum PTH tended to increase in the WL group but not in the WM group (P < 0. 06).", "output": {"entities": {"gene": [{"text": "Serum PTH", "start": 0, "end": 9}]}}, "schema": []}
{"input": "Structure of the EMAPII domain of human aminoacyl-tRNA synthetase complex reveals evolutionary dimer mimicry.", "output": {"entities": {"gene": [{"text": "EMAPII domain", "start": 17, "end": 30}, {"text": "human aminoacyl-tRNA synthetase complex", "start": 34, "end": 73}]}}, "schema": []}
{"input": "METHODS: The passive and active transport of fluorescein through the BRB was quantitated by vitreous fluorometry.", "output": {"entities": {}}, "schema": []}
{"input": "Nerve growth factor (NGF) and retinoic acid (RA) exert important actions on PC12 cells.", "output": {"entities": {"gene": [{"text": "Nerve growth factor", "start": 0, "end": 19}, {"text": "NGF", "start": 21, "end": 24}]}}, "schema": []}
{"input": "The region containing both serines is homologous to the N-terminal destruction box of IkappaBalpha,-beta, and-epsilon.", "output": {"entities": {"gene": [{"text": "IkappaBalpha,-beta, and-epsilon", "start": 86, "end": 117}]}}, "schema": []}
{"input": "This function requires not only the kinase domain of Csk, but also its Src homology 3 (SH3) and SH2 regions.", "output": {"entities": {"gene": [{"text": "Csk", "start": 53, "end": 56}, {"text": "Src homology 3", "start": 71, "end": 85}, {"text": "SH3", "start": 87, "end": 90}, {"text": "SH2", "start": 96, "end": 99}]}}, "schema": []}
{"input": "Furthermore, we showed that ERSF including NF-Y and ATF6alpha and/or beta and capable of binding to ERSE is indeed formed when the cellular UPR is activated.", "output": {"entities": {"gene": [{"text": "ERSF", "start": 28, "end": 32}, {"text": "NF-Y", "start": 43, "end": 47}, {"text": "ATF6alpha and/or beta", "start": 52, "end": 73}]}}, "schema": []}
{"input": "These effects were not seen with SHIP2 possessing a mutation in the SH2 domain (R47G).", "output": {"entities": {"gene": [{"text": "SHIP2", "start": 33, "end": 38}, {"text": "SH2 domain", "start": 68, "end": 78}, {"text": "R47G", "start": 80, "end": 84}]}}, "schema": []}
{"input": "The gonadotrope-specific and regulated expression of the GnRH receptor (GnRH-R) gene is dependent on multiple transcription factors that interact with the noncanonical GnRH-R activating sequence (GRAS), the activator protein-1 (AP-1) element, and the steroidogenic factor-1 (SF-1) binding site.", "output": {"entities": {"gene": [{"text": "GnRH receptor", "start": 57, "end": 70}, {"text": "GnRH-R", "start": 72, "end": 78}, {"text": "noncanonical GnRH-R activating sequence", "start": 155, "end": 194}, {"text": "GRAS", "start": 196, "end": 200}, {"text": "activator protein-1", "start": 207, "end": 226}, {"text": "AP-1", "start": 228, "end": 232}, {"text": "steroidogenic factor-1", "start": 251, "end": 273}, {"text": "SF-1", "start": 275, "end": 279}]}}, "schema": []}
{"input": "METHODS: A structured interview was undertaken at the time of initial consultation and at subsequent 1-year intervals regarding type of BHS, frequency of spells, associated phenomenon, sequelae, family history, and age at termination of spells.", "output": {"entities": {}}, "schema": []}
{"input": "In three cases (21. 4%), the MR imaging was interpreted as negative, but microscopic tumor was shown around seroma on reexcision.", "output": {"entities": {}}, "schema": []}
{"input": "Methylation at both cytosine residues in the E2F element ((m) CG (m) CG) generated a new methylcytosine-specific DNA-protein complex.", "output": {"entities": {"gene": [{"text": "E2F", "start": 45, "end": 48}]}}, "schema": []}
{"input": "These mutations, when placed in a wild-type fliF background, had no mutant phenotype.", "output": {"entities": {"gene": [{"text": "wild-type fliF", "start": 34, "end": 48}]}}, "schema": []}
{"input": "As well, IFN-gamma-induced expression of IRF-1 and its binding to the IRF element is inhibited.", "output": {"entities": {"gene": [{"text": "IFN-gamma", "start": 9, "end": 18}, {"text": "IRF-1", "start": 41, "end": 46}, {"text": "IRF element", "start": 70, "end": 81}]}}, "schema": []}
{"input": "This molecule, wH22xeGFP, consists of the entire humanized anti-FcgammaRI mAb H22 with eGFP genetically fused to the C-terminal end of each CH3 domain. wH22xeGFP binds within the ligand-binding region by its Fc end, as well as outside the ligand-binding region by its Fab ends, thereby cross-linking FcgammaRI.", "output": {"entities": {"gene": [{"text": "wH22xeGFP", "start": 15, "end": 24}, {"text": "entire humanized anti-FcgammaRI mAb H22", "start": 42, "end": 81}, {"text": "eGFP", "start": 87, "end": 91}, {"text": "CH3 domain", "start": 140, "end": 150}, {"text": "wH22xeGFP", "start": 152, "end": 161}, {"text": "Fc", "start": 208, "end": 210}, {"text": "Fab", "start": 268, "end": 271}, {"text": "FcgammaRI", "start": 300, "end": 309}]}}, "schema": []}
{"input": "This interaction is reciprocal, since C/EBP dimer binding to a strong C/EBP site leads to enhanced CREB-1 recruitment to ATF/CREB sites that are weakly bound by CREB.", "output": {"entities": {"gene": [{"text": "C/EBP dimer", "start": 38, "end": 49}, {"text": "C/EBP site", "start": 70, "end": 80}, {"text": "CREB-1", "start": 99, "end": 105}, {"text": "ATF", "start": 121, "end": 124}, {"text": "CREB", "start": 125, "end": 129}, {"text": "CREB", "start": 161, "end": 165}]}}, "schema": []}
{"input": "The metabolic events occurring at or near that structure and involving cyclin D3 cause the translocation of ICP0 to the cytoplasm.", "output": {"entities": {"gene": [{"text": "cyclin D3", "start": 71, "end": 80}, {"text": "ICP0", "start": 108, "end": 112}]}}, "schema": []}
{"input": "Transient transfections showed that a single mutation (556M) decreased TBLV enhancer activity at least 20-fold in two different T-cell lines.", "output": {"entities": {"gene": [{"text": "TBLV enhancer", "start": 71, "end": 84}]}}, "schema": []}
{"input": "Vector stocks containing envelope proteins from three different SIVmac clones, namely, SIVmac239 (T-lymphocyte tropic [T-tropic]), SIVmac316 (macrophage tropic [M-tropic]), and SIVmac1A11 (dualtropic), were tested.", "output": {"entities": {"gene": [{"text": "envelope proteins", "start": 25, "end": 42}]}}, "schema": []}
{"input": "Quantitative PCR studies indicated that synthesis and transport of vector DNA into the nucleus were similar for macrophages infected with the clone 239 and 316 pseudotypes, suggesting that the restriction for SIVmac239 infection is after reverse transcription and nuclear import of viral DNA.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, the anti-interferon functions of vIRF-2 may contribute to the establishment of a chronic or latent infection.", "output": {"entities": {"gene": [{"text": "anti-interferon", "start": 10, "end": 25}, {"text": "vIRF-2", "start": 39, "end": 45}]}}, "schema": []}
{"input": "Interestingly, the activity of IkappaB kinase (IKK-beta), which plays an essential role in NF-kappaB activation through IkappaB phosphorylation, was largely enhanced in paclitaxel-treated cells, detected as IkappaBalpha phosphorylation.", "output": {"entities": {"gene": [{"text": "IkappaB kinase", "start": 31, "end": 45}, {"text": "IKK-beta", "start": 47, "end": 55}, {"text": "NF-kappaB", "start": 91, "end": 100}, {"text": "IkappaB", "start": 120, "end": 127}, {"text": "IkappaBalpha", "start": 207, "end": 219}]}}, "schema": []}
{"input": "We propose that TFOs represent a therapeutic potential to specifically diminish the expression of c-sis/PDGF-B proto-oncogene in various pathologic settings where constitutive expression of this gene has been observed.", "output": {"entities": {"gene": [{"text": "c-sis", "start": 98, "end": 103}, {"text": "PDGF-B", "start": 104, "end": 110}]}}, "schema": []}
{"input": "Rapid evolution of the DNA-binding site in LAGLIDADG homing endonucleases.", "output": {"entities": {"gene": [{"text": "LAGLIDADG homing endonucleases", "start": 43, "end": 73}]}}, "schema": []}
{"input": "Copyright 2001 Academic Press.", "output": {"entities": {}}, "schema": []}
{"input": "Interestingly, the similarities with the endophilin proteins cover the entire sequence of the SH3GLB family, suggesting a common fold and presumably a common mode of action.", "output": {"entities": {"gene": [{"text": "endophilin proteins", "start": 41, "end": 60}, {"text": "SH3GLB family", "start": 94, "end": 107}]}}, "schema": []}
{"input": "Mental rotation of paired figures engendered activation in the left superior parietal lobule and the right frontal medial gyrus.", "output": {"entities": {}}, "schema": []}
{"input": "We also reported the identification of three corresponding alternative first exons and an intronic promoter in the human PDE5A gene.", "output": {"entities": {"gene": [{"text": "human PDE5A gene", "start": 115, "end": 131}]}}, "schema": []}
{"input": "The glucose/insulin stimulation was inhibited by the addition of polyunsaturated fatty acids.", "output": {"entities": {"gene": [{"text": "insulin", "start": 12, "end": 19}]}}, "schema": []}
{"input": "In the present work, the complete genome sequences of Pyrococcus horikoshii and Pyrococcus abyssi, two species in a genus of hyperthermophilic archaeon (archaebacterium), were compared to detect large genome polymorphisms linked with restriction-modification gene homologs.", "output": {"entities": {}}, "schema": []}
{"input": "This animal model of dystonia appears to be a model of NAD in man from the viewpoint of treatment-response.", "output": {"entities": {}}, "schema": []}
{"input": "Peripheral and preemptive opioid antinociception in a mouse visceral pain model.", "output": {"entities": {}}, "schema": []}
{"input": "Twenty-six (55%) (95% CI, 41-69%) patients experienced > or = grade 3 acute toxicity (RTOG).", "output": {"entities": {}}, "schema": []}
{"input": "No' TATA' motif was identified near either the GABPalpha or ATPsynCF6 transcription start sites.", "output": {"entities": {"gene": [{"text": "GABPalpha", "start": 47, "end": 56}, {"text": "ATPsynCF6", "start": 60, "end": 69}]}}, "schema": []}
{"input": "Significantly higher lung function parameters were obtained in extubated recipients of LPD preserved grafts 2 weeks after TX.", "output": {"entities": {}}, "schema": []}
{"input": "Acquired antithrombin deficiency in sepsis.", "output": {"entities": {"gene": [{"text": "antithrombin", "start": 9, "end": 21}]}}, "schema": []}
{"input": "In addition, we have isolated a genomic fragment containing the most distal 5' sequences of the major GGT mRNA in HepG2 cells.", "output": {"entities": {"gene": [{"text": "GGT mRNA", "start": 102, "end": 110}]}}, "schema": []}
{"input": "(1997) Nature 387, 370-376)], we suggest that the metal fluoride ions replaced phosphate at the two ATP-binding sites of the iron protein, Kp2.", "output": {"entities": {"gene": [{"text": "Kp2", "start": 139, "end": 142}]}}, "schema": []}
{"input": "Expression of herpes simplex virus type 2 US3 affects the Cdc42/Rac pathway and attenuates c-Jun N-terminal kinase activation.", "output": {"entities": {"gene": [{"text": "herpes simplex virus type 2 US3", "start": 14, "end": 45}, {"text": "Cdc42", "start": 58, "end": 63}, {"text": "Rac", "start": 64, "end": 67}, {"text": "c-Jun N-terminal kinase", "start": 91, "end": 114}]}}, "schema": []}
{"input": "If you think education is expensive--try ignorance--Bok' s Law.", "output": {"entities": {}}, "schema": []}
{"input": "To study the in vivo role of p16. 7, a phi29 mutant containing a suppressible mutation in gene 16. 7 was constructed.", "output": {"entities": {"gene": [{"text": "p16. 7", "start": 29, "end": 35}, {"text": "gene 16. 7", "start": 90, "end": 100}]}}, "schema": []}
{"input": "To the best of our knowledge, SNTCS is highly malignant.", "output": {"entities": {}}, "schema": []}
{"input": "The extraordinary stability of peptide--gp96 complexes and the plasticity of the peptide-binding pocket support the proposed relay of diverse peptides to MHC and/or other molecules via molecular recognition.", "output": {"entities": {"gene": [{"text": "peptide--gp96 complexes", "start": 31, "end": 54}, {"text": "MHC", "start": 154, "end": 157}]}}, "schema": []}
{"input": "High-affinity binding of NF-1 to PSE-B, but not to PSE-A, was confirmed by competition of DNA-protein interactions by using NF-1 DNA elements and antibodies.", "output": {"entities": {"gene": [{"text": "NF-1", "start": 25, "end": 29}, {"text": "PSE-B", "start": 33, "end": 38}, {"text": "PSE-A", "start": 51, "end": 56}, {"text": "NF-1", "start": 124, "end": 128}]}}, "schema": []}
{"input": "Coexpression of the p120 (ctn) protein with an N-terminal deletion, which eliminates some potential tyrosine phosphorylation sites, or the protein with a single amino acid substitution (tyrosine at 217 to phenylalanine) resulted in an increase in the aggregation of v-Src-transformed EL and EalphaCL cells.", "output": {"entities": {"gene": [{"text": "p120", "start": 20, "end": 24}, {"text": "ctn", "start": 26, "end": 29}, {"text": "v-Src", "start": 266, "end": 271}]}}, "schema": []}
{"input": "We show that p73 can transcriptionally inhibit a number of cellular and viral promoters.", "output": {"entities": {"gene": [{"text": "p73", "start": 13, "end": 16}]}}, "schema": []}
{"input": "RESULTS: Of the 24 patients, 6 had Grade 1 pneumonitis, and 13 had Grade 2 pneumonitis.", "output": {"entities": {}}, "schema": []}
{"input": "In contrast, we did not detect a significant correlation between plasma TNFalpha and radiation pneumonitis.", "output": {"entities": {"gene": [{"text": "plasma TNFalpha", "start": 65, "end": 80}]}}, "schema": []}
{"input": "METHODS: Sixteen pigs were assigned randomly to control and shock groups.", "output": {"entities": {}}, "schema": []}
{"input": "Identification of pulmonary vein stenosis after radiofrequency ablation for atrial fibrillation using MRI.", "output": {"entities": {}}, "schema": []}
{"input": "Tumor cell lines transduced at an MOI of 8 for 3 days led to > 90% gene transfer efficiency.", "output": {"entities": {}}, "schema": []}
{"input": "Treatment includes both medical and surgical options, with medical therapy further subclassified into pharmacologic and pneumatic dilation.", "output": {"entities": {}}, "schema": []}
{"input": "Finally, we compared the differential screening techniques in terms of sensitivity, efficiency and occurrence of false positives.", "output": {"entities": {}}, "schema": []}
{"input": "Serial US images were obtained before and 20, 30, 40, 50, 60, 90, 120, 150, 180, 240, and 300 s after intravenous injection of 2 g of contrast agent using conventional and harmonic PD US.", "output": {"entities": {}}, "schema": []}
{"input": "To investigate the effects of exogenous hyaluronic acid, the development of port-site metastasis was examined using mouse adenocarcinoma cell-line colon 26 cells.", "output": {"entities": {}}, "schema": []}
{"input": "Cytomegalovirus, Chlamydia pneumoniae, and Helicobacter pylori IgG antibodies and restenosis after stent implantation: an angiographic and intravascular ultrasound study.", "output": {"entities": {"gene": [{"text": "IgG antibodies", "start": 63, "end": 77}]}}, "schema": []}
{"input": "Responses of single-unit carotid body chemoreceptors in adult rats.", "output": {"entities": {}}, "schema": []}
{"input": "Architecture and anatomy of the genomic locus encoding the human leukemia-associated transcription factor RUNX1/AML1.", "output": {"entities": {"gene": [{"text": "RUNX1", "start": 106, "end": 111}, {"text": "AML1", "start": 112, "end": 116}]}}, "schema": []}
{"input": "Therefore, we suggested that both proteins might belong to the PLTP family.", "output": {"entities": {"gene": [{"text": "PLTP family", "start": 63, "end": 74}]}}, "schema": []}
{"input": "In this paper the tyrosine dephosphorylating enzymes, the protein-tyrosine phosphatases (PTPs), are studied which can be grouped into two subfamilies, the soluble PTPs and the receptor PTPs (RPTPs).", "output": {"entities": {"gene": [{"text": "protein-tyrosine phosphatases", "start": 58, "end": 87}, {"text": "PTPs", "start": 89, "end": 93}, {"text": "soluble PTPs", "start": 155, "end": 167}, {"text": "receptor PTPs", "start": 176, "end": 189}, {"text": "RPTPs", "start": 191, "end": 196}]}}, "schema": []}
{"input": "The Ig-related, typical metazoan, module is classified to the disulphide lacking Ig members and represents the phylogenetic earliest member of this group.", "output": {"entities": {"gene": [{"text": "Ig", "start": 4, "end": 6}, {"text": "Ig members", "start": 81, "end": 91}]}}, "schema": []}
{"input": "The Sox gene family (Sry like HMG box gene) is characterised by a conserved DNA sequence encoding a domain of approximately 80 amino acids which is responsible for sequence specific DNA binding.", "output": {"entities": {"gene": [{"text": "Sox gene family", "start": 4, "end": 19}, {"text": "Sry like HMG box gene", "start": 21, "end": 42}]}}, "schema": []}
{"input": "While these results are consistent with previously reported effects of the C-terminal domain on nucleotide binding, they also demonstrate that interactions with the N-terminal domains are necessary to inhibit proton transport.", "output": {"entities": {}}, "schema": []}
{"input": "Respiratory parameters suggested that M6G produced less respiratory depression than morphine.", "output": {"entities": {}}, "schema": []}
{"input": "This supports previous arguments for the improbability of biological effects at UHF frequencies unless a mechanism can be found for accumulating energy over time and space and focussing it.", "output": {"entities": {}}, "schema": []}
{"input": "To assess the maximum oxygen uptake (V' O2 max) of Hong Kong Chinese children and to explore its association with respiratory illnesses, we conducted the Multistage Fitness Test (MFT), a 20-m shuttle run test, in 1, 427 schoolchildren aged between 8-12 years.", "output": {"entities": {}}, "schema": []}
{"input": "By analyzing 5'-deletion insulin promoter-reporter constructs in transient transfections of clonal INS-1 beta-cells, we located activating Hh-responsive regions within the rat insulin I promoter that include the glucose-response elements Far (E2) and Flat (A2/A3).", "output": {"entities": {"gene": [{"text": "insulin promoter-reporter constructs", "start": 25, "end": 61}, {"text": "INS-1 beta", "start": 99, "end": 109}, {"text": "Hh", "start": 139, "end": 141}, {"text": "rat insulin I promoter", "start": 172, "end": 194}]}}, "schema": []}
{"input": "The androgen receptor (AR) amino-terminus imposes androgen-specific regulation of AR gene expression via an exonic enhancer.", "output": {"entities": {"gene": [{"text": "androgen receptor", "start": 4, "end": 21}, {"text": "AR", "start": 23, "end": 25}, {"text": "AR gene", "start": 82, "end": 89}]}}, "schema": []}
{"input": "A major mechanism by which estrogens prevent osteoporosis seems to be repression of transcription of NF-kappa B target genes, such as the osteoclast-activating cytokines interleukin-6 and interleukin-1.", "output": {"entities": {"gene": [{"text": "NF-kappa B target genes", "start": 101, "end": 124}, {"text": "interleukin-6", "start": 170, "end": 183}, {"text": "interleukin-1", "start": 188, "end": 201}]}}, "schema": []}
{"input": "To identify the important cis-DNA regulatory element (s) involved in the tissue-, region-, and cell-specific expression of the mE-RABP gene, the 5-kb DNA fragment was sequenced.", "output": {"entities": {"gene": [{"text": "mE-RABP gene", "start": 127, "end": 139}]}}, "schema": []}
{"input": "In the mouse, both genes reside in the syntenic region 8E1 on chromosome 8.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of the genome sequence revealed 26, 588 protein-encoding transcripts for which there was strong corroborating evidence and an additional approximately 12, 000 computationally derived genes with mouse matches or other weak supporting evidence.", "output": {"entities": {}}, "schema": []}
{"input": "The corresponding genotype was determined with a restriction enzyme-based assay.", "output": {"entities": {}}, "schema": []}
{"input": "By Caveman.", "output": {"entities": {}}, "schema": []}
{"input": "Multistage models and the A-bomb survivor data: implications for carcinogenic mechanisms?", "output": {"entities": {}}, "schema": []}
{"input": "The revitalization of surgery for Parkinson' s disease (PD) has fueled discussion about the best methodology to define the target.", "output": {"entities": {}}, "schema": []}
{"input": "Corneal scrapping and deep stromal biopsy were obtained and stained for microscopic evaluation with periodic acid-Schiff, Giemsa, and Gomori' s methenamine silver stains.", "output": {"entities": {}}, "schema": []}
{"input": "These results indicate that BACM has antiplaque and stronger antidegradation effects than GLCM.", "output": {"entities": {}}, "schema": []}
{"input": "Multidrug resistance in Saccharomyces cerevisiae mainly results from the overexpression of genes coding for the membrane efflux pumps, the major facilitators and the ABC binding cassette transporters, under the control of key transcription regulators encoded by the PDR1 and PDR3 genes.", "output": {"entities": {"gene": [{"text": "ABC binding cassette transporters", "start": 166, "end": 199}, {"text": "PDR1", "start": 266, "end": 270}, {"text": "PDR3 genes", "start": 275, "end": 285}]}}, "schema": []}
{"input": "Susceptibility to ischemia-induced arrhythmias was lower in 1-week diabetics: only 42% of diabetic hearts exhibited ventricular tachycardia (VT) and 16% had short episodes of ventricular fibrillation (VF) as compared to VT 100% and VF 70% (including sustained VF 36%) in the non-diabetics (P < 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "A picture is emerging showing a gradient of function among p53, p73, p63 ranging from tumor suppression to development.", "output": {"entities": {"gene": [{"text": "p53", "start": 59, "end": 62}, {"text": "p73", "start": 64, "end": 67}, {"text": "p63", "start": 69, "end": 72}]}}, "schema": []}
{"input": "This could lead to subsequent outbreaks if Babesia carrier animals were to be introduced into the herd.", "output": {"entities": {}}, "schema": []}
{"input": "Contagious bovine pleuropneumonia is a major threat for cattle in Africa.", "output": {"entities": {}}, "schema": []}
{"input": "Baseline BMD values were significantly lower in the oligo-amenorrheic group than in the two others at the level of lumbar spine (anteroposterior view: 0. 941 +/-0. 039 in oligo-amenorrheic vs 1. 077 +/-0. 029 or 1. 051 +/-0. 017 g x cm (-2), P < 0. 005, in the eumenorrheic and contraceptive user groups, respectively) but not in weight-bearing bone such as proximal and midshaft femur.", "output": {"entities": {}}, "schema": []}
{"input": "The distribution of red rice cultivation in Sri Lanka is coincident with the HIDD villages.", "output": {"entities": {}}, "schema": []}
{"input": "The increase in number of terminal hairs, which are defined as hairs more than 60 microm in diameter, in the designated area (0. 5 cm square = 0. 25 cm2 area) of the procyanidin B-2 group subjects after the 6-month trial was significantly greater than that of the placebo control group subjects (procyanidin B-2, 1. 99 +/-2. 58 (mean +/-SD)/0. 25 cm2; placebo,-0. 82 +/-3. 40 (mean +/-SD)/0. 25 cm2; P < 0. 02, two-sample t test).", "output": {"entities": {}}, "schema": []}
{"input": "Ectopic expression of the dominant mutant Lg3 allele is believed to cause the phenotype.", "output": {"entities": {"gene": [{"text": "dominant mutant Lg3 allele", "start": 26, "end": 52}]}}, "schema": []}
{"input": "High plasma AVP levels observed in the two cases suggest that SSRIs stimulate AVP secretion, thereby causing SIADH.", "output": {"entities": {"gene": [{"text": "plasma AVP", "start": 5, "end": 15}, {"text": "AVP", "start": 78, "end": 81}]}}, "schema": []}
{"input": "Thus, in T47D breast carcinoma cells, IL-6 acts in synergy with EGF receptor autocrine activity to signal through the MAPK/PI3K pathways.", "output": {"entities": {"gene": [{"text": "IL-6", "start": 38, "end": 42}, {"text": "EGF receptor", "start": 64, "end": 76}, {"text": "MAPK", "start": 118, "end": 122}, {"text": "PI3K", "start": 123, "end": 127}]}}, "schema": []}
{"input": "Human homologue of yeast Rad23 protein A interacts with p300/cyclic AMP-responsive element binding (CREB)-binding protein to down-regulate transcriptional activity of p53.", "output": {"entities": {"gene": [{"text": "Human homologue of yeast Rad23 protein A", "start": 0, "end": 40}, {"text": "p300", "start": 56, "end": 60}, {"text": "cyclic AMP-responsive element binding (CREB)-binding protein", "start": 61, "end": 121}, {"text": "p53", "start": 167, "end": 170}]}}, "schema": []}
{"input": "Most patients harboring metronidazole-and clarithromycin-resistant strains were eradicated at an equal rate by each of the three regimens.", "output": {"entities": {}}, "schema": []}
{"input": "Binding of cell type-specific nuclear proteins to the 5'-flanking region of maize C4 phosphoenolpyruvate carboxylase gene confers its differential transcription in mesophyll cells.", "output": {"entities": {"gene": [{"text": "maize C4 phosphoenolpyruvate carboxylase gene", "start": 76, "end": 121}]}}, "schema": []}
{"input": "RESULTS: During the stabilization period, PaCO2 (mean +/-SD) was 33 +/-5 mm Hg, and arrhythmias were not detected.", "output": {"entities": {}}, "schema": []}
{"input": "BACKGROUND: Previous studies have indicated that the 60-, 30-, 28-and 12-item versions of the General Health Questionnaire (GHQ) are liable to retest effects, especially when administered multiple times with short intervals.", "output": {"entities": {}}, "schema": []}
{"input": "Acute effects of LI 160 (extract of Hypericum perforatum, St John' s wort) and two of its constituents on neuroendocrine responses in the rat.", "output": {"entities": {}}, "schema": []}
{"input": "Decreased serum ceruloplasmin and copper levels in cervical dystonia.", "output": {"entities": {"gene": [{"text": "serum ceruloplasmin", "start": 10, "end": 29}]}}, "schema": []}
{"input": "A microsporidian, Nosema algerae Vavra and undeen, was found parasitizing larvae and adults of a laboratory colony of Culex pipiens L. originated from Gharbia Governorate.", "output": {"entities": {}}, "schema": []}
{"input": "Molecular cloning and characterization of OsPSK, a gene encoding a precursor for phytosulfokine-alpha, required for rice cell proliferation.", "output": {"entities": {"gene": [{"text": "OsPSK", "start": 42, "end": 47}, {"text": "phytosulfokine-alpha", "start": 81, "end": 101}]}}, "schema": []}
{"input": "Plasma DHE concentration rose promptly above 5 ng/ml after the application of the PSA tape onto the damaged skin in hairless rat.", "output": {"entities": {}}, "schema": []}
{"input": "Implications in biomonitoring of the observed accumulation patterns, especially in the different tissues of Posidonia oceanica, are discussed.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, Xlim-1 not only contains a unique tyrosine-rich activation domain but also contains a negative regulatory domain in CT239-403, suggesting a complex regulatory mechanism underlying the transcriptional activity of Xlim-1 in the organizer.", "output": {"entities": {"gene": [{"text": "Xlim-1", "start": 6, "end": 12}, {"text": "Xlim-1", "start": 218, "end": 224}]}}, "schema": []}
{"input": "After allowing time for absorption, participants completed a bridge simulator task.", "output": {"entities": {}}, "schema": []}
{"input": "Functional analysis of various PTP-deficient DT40 B cell lines stably expressing wild-type chimeric Fc gamma RIIB1-PECAM-1 receptor indicated that cytoplasmic Src homology 2-domain-containing phosphatases, SHP-1 and SHP-2, were both necessary and sufficient to deliver inhibitory negative regulation upon coligation of BCR complex with inhibitory receptor.", "output": {"entities": {"gene": [{"text": "PTP", "start": 31, "end": 34}, {"text": "Fc gamma RIIB1-PECAM-1 receptor", "start": 100, "end": 131}, {"text": "cytoplasmic Src homology 2-domain-containing phosphatases", "start": 147, "end": 204}, {"text": "SHP-1", "start": 206, "end": 211}, {"text": "SHP-2", "start": 216, "end": 221}, {"text": "BCR complex", "start": 319, "end": 330}]}}, "schema": []}
{"input": "Substitutions in the YFV Ag-binding region (ABR) occur at four of the eight highly conserved residues that are essential for binding of peptide-Ag in the class Ia molecules.", "output": {"entities": {"gene": [{"text": "YFV Ag-binding region", "start": 21, "end": 42}, {"text": "ABR", "start": 44, "end": 47}]}}, "schema": []}
{"input": "Similarly, curcumin (diferuloylmethane), an anti-inflammatory agent, suppressed OSM-stimulated STAT1 phosphorylation, DNA-binding activity of STAT1, and c-Jun N-terminal kinase activation without affecting JAK1, JAK2, JAK3, ERK1/2, and p38 phosphorylation.", "output": {"entities": {"gene": [{"text": "OSM", "start": 80, "end": 83}, {"text": "STAT1", "start": 95, "end": 100}, {"text": "STAT1", "start": 142, "end": 147}, {"text": "c-Jun N-terminal kinase", "start": 153, "end": 176}, {"text": "JAK1", "start": 206, "end": 210}, {"text": "JAK2", "start": 212, "end": 216}, {"text": "JAK3", "start": 218, "end": 222}, {"text": "ERK1/2", "start": 224, "end": 230}, {"text": "p38", "start": 236, "end": 239}]}}, "schema": []}
{"input": "In contrast, the failure of the QKTT motif and TGN46 cytoplasmic tail to induce steady-state ER localization of vesicular stomatitis virus glycoprotein (VSVG) chimeras in HeLa and NRK cells indicates that significant differences in early secretory trafficking also exist.", "output": {"entities": {"gene": [{"text": "vesicular stomatitis virus glycoprotein", "start": 112, "end": 151}, {"text": "VSVG", "start": 153, "end": 157}]}}, "schema": []}
{"input": "A cDNA clone encoding C2H2-type zinc finger protein, SCOF-1, was isolated from soybean.", "output": {"entities": {"gene": [{"text": "C2H2-type zinc finger protein", "start": 22, "end": 51}, {"text": "SCOF-1", "start": 53, "end": 59}]}}, "schema": []}
{"input": "Consistent with the specificity observed for the interaction of DmCKIIalpha with these bHLH proteins, sequence alignment suggests that only m5, m7, and m8 contain a consensus site for phosphorylation by CKII within a subdomain unique to these three proteins.", "output": {"entities": {"gene": [{"text": "DmCKIIalpha", "start": 64, "end": 75}, {"text": "bHLH proteins", "start": 87, "end": 100}, {"text": "m5", "start": 140, "end": 142}, {"text": "m7", "start": 144, "end": 146}, {"text": "m8", "start": 152, "end": 154}, {"text": "CKII", "start": 203, "end": 207}]}}, "schema": []}
{"input": "Apart from antimicrobial properties, recent data indicate that PMN also exert anti-inflammatory effects by stimulation and release of cytokine antagonists such as interleukin-1 receptor antagonist (IL-1ra).", "output": {"entities": {"gene": [{"text": "interleukin-1 receptor antagonist", "start": 163, "end": 196}, {"text": "IL-1ra", "start": 198, "end": 204}]}}, "schema": []}
{"input": "The purpose of this investigation was to study the morphological characteristics of the fibrous tissue capsule resulting from the implantation of aluminum calcium phosphate (ALCAP) and hydroxyapetite (HA) bioceramics.", "output": {"entities": {}}, "schema": []}
{"input": "Sevelamer hydrochloride (Renagel) is a nonabsorbed phosphate-binding polymer marketed for the treatment of hyperphosphatemia in adult patients receiving hemodialysis.", "output": {"entities": {}}, "schema": []}
{"input": "The pharmacokinetic profiles of digoxin and warfarin were not altered by the simultaneous and continued administration of sevelamer.", "output": {"entities": {}}, "schema": []}
{"input": "Before PO3 administration, more than half (57. 4%) of the patients received only 1 or 2 antituberculous drugs (ethambutole and ethionamide or ethambutole and oprofloxacin).", "output": {"entities": {}}, "schema": []}
{"input": "Can survival be prolonged for patients with hormone-resistant prostate cancer?", "output": {"entities": {}}, "schema": []}
{"input": "Patients were divided into two group; Control group A in which a hot-water circulating system was used and group B in which a transtracheal heating and humidification system by ANAMED HUMITUBE was used, during gastric cancer operation.", "output": {"entities": {}}, "schema": []}
{"input": "The present data also demonstrate that ectopic expression of blr1 increased JNK/SAPK activity, but JNK/SAPK activation was not needed for accelerated RA-induced differentiation and growth arrest.", "output": {"entities": {"gene": [{"text": "blr1", "start": 61, "end": 65}, {"text": "JNK", "start": 76, "end": 79}, {"text": "SAPK", "start": 80, "end": 84}, {"text": "JNK", "start": 99, "end": 102}, {"text": "SAPK", "start": 103, "end": 107}]}}, "schema": []}
{"input": "RESULTS: The parameters SF2 and plating efficiency were stable throughout the 4-year test period.", "output": {"entities": {}}, "schema": []}
{"input": "Also, small, sense and antisense approximately 22 nt RNAs, derived from the satRNA, were associated with the replicating satellite.", "output": {"entities": {}}, "schema": []}
{"input": "VE-DEF animals had significantly higher (p < 0. 05) levels of myocardial lipid peroxidation and lower (p < 0. 05) protein thiols following I-R compared to the CON animals.", "output": {"entities": {}}, "schema": []}
{"input": "Grippers with integrated piezoresistive force sensors and with attached strain gauges have been reported.", "output": {"entities": {}}, "schema": []}
{"input": "The child left behind.", "output": {"entities": {}}, "schema": []}
{"input": "Transition between P-and H-BPPV was found in 6 cases.", "output": {"entities": {}}, "schema": []}
{"input": "The contrasting effects of dopaminergic stimulation on the motor performance and on some aspects of cognitive processing suggest the existence of complex interactions within pre-and postsynaptic brain dopamine receptors, and an intervention of segregated basal ganglia-prefrontal cortex loops in motor and cognitive behaviour.", "output": {"entities": {"gene": [{"text": "brain dopamine receptors", "start": 195, "end": 219}]}}, "schema": []}
{"input": "HexA71 negatively affects RpoS, as the levels of this alternative sigma factor are higher in the HexA-mutant than in the HexA + strain.", "output": {"entities": {"gene": [{"text": "HexA71", "start": 0, "end": 6}, {"text": "RpoS", "start": 26, "end": 30}, {"text": "sigma factor", "start": 66, "end": 78}, {"text": "HexA-mutant", "start": 97, "end": 108}, {"text": "HexA +", "start": 121, "end": 127}]}}, "schema": []}
{"input": "Multiple copies of rsmB + DNA, on the other hand, stimulate exoenzyme production by relieving the negative effects of a chromosomal copy of hexA +.", "output": {"entities": {"gene": [{"text": "rsmB + DNA", "start": 19, "end": 29}, {"text": "hexA +", "start": 140, "end": 146}]}}, "schema": []}
{"input": "0%) and IL-12 (42. 6% vs.", "output": {"entities": {"gene": [{"text": "IL-12", "start": 8, "end": 13}]}}, "schema": []}
{"input": "Systematic review of diagnostic tests for vaginal trichomoniasis.", "output": {"entities": {}}, "schema": []}
{"input": "CHAP and the Department of Veterans Affairs.", "output": {"entities": {}}, "schema": []}
{"input": "More importantly, this fusion converted a less effective vaccine into one with significant potency against established E7-expressing metastatic tumors.", "output": {"entities": {"gene": [{"text": "E7", "start": 119, "end": 121}]}}, "schema": []}
{"input": "We compared previously the methylation status between normal liver and liver tumors in SV40 T/t antigen transgenic mice (MT-D2 mice) using Restriction Landmark Genomic Scanning for Methylation (RLGS-M) and identified several loci/spots that appeared to be methylated frequently in liver tumors.", "output": {"entities": {"gene": [{"text": "SV40 T/t antigen", "start": 87, "end": 103}]}}, "schema": []}
{"input": "The Genescan program predicted an open reading frame of a novel, intron-less gene adjacent to the B236 spot that encodes a putative 493-amino acid protein containing the SNAG repressor motif in the NH2-terminal region and five C2H2-type zinc finger motifs in the COOH-terminal half.", "output": {"entities": {}}, "schema": []}
{"input": "Northern blot analysis revealed that mlt 1 is normally expressed in brain, spleen, stom ach, and liver.", "output": {"entities": {"gene": [{"text": "mlt 1", "start": 37, "end": 42}]}}, "schema": []}
{"input": "Treatment of N18TG-2 cells with a demethylating agent, 5-aza-deoxycytidine, resulted in an expression of mlt 1, indicating that the repression of mlt 1 is attributable to methylation Thus, mlt 1 is a novel target gene that is silenced by methylation during liver tumorigenesis initiated by SV40 T antigen.", "output": {"entities": {"gene": [{"text": "mlt 1", "start": 105, "end": 110}, {"text": "mlt 1", "start": 146, "end": 151}, {"text": "mlt 1", "start": 189, "end": 194}, {"text": "SV40 T antigen", "start": 290, "end": 304}]}}, "schema": []}
{"input": "These results suggested a critical role for tyrosine residue 1229 in the regulation of L1 endocytosis.", "output": {"entities": {"gene": [{"text": "L1", "start": 87, "end": 89}]}}, "schema": []}
{"input": "Folate metabolism in the human malaria parasite Plasmodium falciparum is an essential activity for cell growth and replication, and the target of an important class of therapeutic agents in widespread use.", "output": {"entities": {}}, "schema": []}
{"input": "The BFA System reads a text file with flows, measured with fluorescent microsphere technique, and constructs the lung anatomy with volumetric pixels showing the flows with a color schema.", "output": {"entities": {}}, "schema": []}
{"input": "Retinoids participate in the onset of differentiation, apoptosis and the inhibition of growth in a wide variety of normal and cancerous cells.", "output": {"entities": {}}, "schema": []}
{"input": "These results indicate that evaluation of exposure to S. neurona by WB analysis of serum may be misleading in young horses.", "output": {"entities": {}}, "schema": []}
{"input": "Drosophila Menin1 gene transcripts use alternative polyadenylation sites resulting in 4. 3 and 5-kb messages.", "output": {"entities": {"gene": [{"text": "Drosophila Menin1 gene transcripts", "start": 0, "end": 34}]}}, "schema": []}
{"input": "Sequence analysis indicates that RBP21 shares homology with other retinoblastoma-binding proteins in the pRb-binding motif LxCxE at the C-terminal region.", "output": {"entities": {"gene": [{"text": "RBP21", "start": 33, "end": 38}, {"text": "retinoblastoma-binding proteins", "start": 66, "end": 97}, {"text": "pRb-binding motif", "start": 105, "end": 122}]}}, "schema": []}
{"input": "In addition, the consensus amino acid motif for serine threonine receptor kinases was also present.", "output": {"entities": {"gene": [{"text": "serine threonine receptor kinases", "start": 48, "end": 81}]}}, "schema": []}
{"input": "We have also isolated and analyzed the 5' flanking region of the pea 33RNP gene.", "output": {"entities": {"gene": [{"text": "33RNP gene", "start": 69, "end": 79}]}}, "schema": []}
{"input": "OsBBPI was found to be rapidly induced in rice seedling leaf in response to cut, exogenous jasmonic acid (JA), and two potent protein phosphatase 2A (PP2A) inhibitors, cantharidin (CN) and endothall (EN), in a light/dark-, time-and dose-dependent manner; this induction was completely inhibited by cycloheximide (CHX), indicating a requirement for de novo protein synthesis in its induction.", "output": {"entities": {"gene": [{"text": "OsBBPI", "start": 0, "end": 6}, {"text": "cut", "start": 76, "end": 79}, {"text": "protein phosphatase 2A", "start": 126, "end": 148}, {"text": "PP2A", "start": 150, "end": 154}]}}, "schema": []}
{"input": "The effects of chlordiazepoxide (2. 5-15. 0mg/kg), a full benzodiazepine receptor agonist, and bretazenil (5. 0-30. 0mg/kg), a partial benzodiazepine receptor agonist, were examined in the murine elevated plus-maze paradigm.", "output": {"entities": {"gene": [{"text": "benzodiazepine receptor", "start": 58, "end": 81}, {"text": "benzodiazepine receptor", "start": 135, "end": 158}]}}, "schema": []}
{"input": "However, plasmids carrying the yeast TyrRS gene could not be stably maintained in E. coli.", "output": {"entities": {"gene": [{"text": "yeast TyrRS gene", "start": 31, "end": 47}]}}, "schema": []}
{"input": "In mammalian tissue culture cells, overexpression of any of the four mouse deltex homologs suppressed the transcriptional activity of E47, a basic helix-loop-helix (bHLH) protein, in a manner similar to suppression by an activated form of human Notch1 or human DTX1.", "output": {"entities": {"gene": [{"text": "E47", "start": 134, "end": 137}, {"text": "basic helix-loop-helix (bHLH) protein", "start": 141, "end": 178}, {"text": "human Notch1", "start": 239, "end": 251}, {"text": "human DTX1", "start": 255, "end": 265}]}}, "schema": []}
{"input": "Multiparous women presented higher BMI (P = 0. 01) and PBF (P = 0. 03) compared with primi-and nulliparous groups.", "output": {"entities": {}}, "schema": []}
{"input": "The authors did not detect any significant correlations between parameters of the lipids of bone marrow and leptin levels in serum and bone marrow.", "output": {"entities": {"gene": [{"text": "leptin", "start": 108, "end": 114}]}}, "schema": []}
{"input": "The position of the analyst as expert: yesterday and today.", "output": {"entities": {}}, "schema": []}
{"input": "Our results suggest that the central role of the Notch-CBF1/RBP-Jkappa signaling pathway in cell fate decisions renders it susceptible to pathways of viral replication and oncogenic conversion.", "output": {"entities": {"gene": [{"text": "Notch", "start": 49, "end": 54}, {"text": "CBF1", "start": 55, "end": 59}, {"text": "RBP-Jkappa", "start": 60, "end": 70}]}}, "schema": []}
{"input": "Using a novel method combining chromatin immunoprecipitation and genomic array hybridization, we have identified a 460-kb CENP-A-binding DNA domain of a neocentromere derived from the 20p12 region of an invdup (20p) human marker chromosome.", "output": {"entities": {"gene": [{"text": "460-kb CENP-A-binding DNA domain", "start": 115, "end": 147}]}}, "schema": []}
{"input": "We describe a total of 39 DEAH helicases in these four species.", "output": {"entities": {"gene": [{"text": "DEAH helicases", "start": 26, "end": 40}]}}, "schema": []}
{"input": "Two cases with marked chronic arm lymphoedema reported major and persistent improvements in arm volume for at least 12 months after treatment with HBO2.", "output": {"entities": {}}, "schema": []}
{"input": "The sensitivity of human neuroblastoma cells SK-N-SH to undergo apoptosis induced by thapsigargin was examined.", "output": {"entities": {}}, "schema": []}
{"input": "Prophylactic lymph node dissection or radiation therapy to the nodal chain may decrease local recurrence but does not consistently affect overall survival.", "output": {"entities": {}}, "schema": []}
{"input": "Currently, the clinical use of 5-aminolaevulinic acid (ALA) induced protoporphyrin IX (PPIX) for photodynamic therapy (PDT) is limited by the maximum tolerated oral ALA dose (60 mg/kg).", "output": {"entities": {"gene": [{"text": "protoporphyrin IX", "start": 68, "end": 85}, {"text": "PPIX", "start": 87, "end": 91}]}}, "schema": []}
{"input": "We can classify antibiotics into two groups based on initial bactericidal activity against P. aeruginosa; one class is antibiotics having rapid initial killing such as AMK, IPM and PAPM, the other is CAZ, MEPM showing slow initial killing.", "output": {"entities": {}}, "schema": []}
{"input": "Managing HIV.", "output": {"entities": {}}, "schema": []}
{"input": "In Klinefelter' s syndrome (47XXY), serum testosterone levels are at the lower end of the normal range and dihydrotestosterone levels are low.", "output": {"entities": {}}, "schema": []}
{"input": "The histamine H1 receptor antagonists (antihistamines) are an important class of medications used for the relief of common symptoms associated with hyperhistaminic conditions occurring in children and adults.", "output": {"entities": {"gene": [{"text": "histamine H1 receptor", "start": 4, "end": 25}]}}, "schema": []}
{"input": "Conclusion: The Lp (a) levels in these children were the lower ever reported.", "output": {"entities": {"gene": [{"text": "Lp (a)", "start": 16, "end": 22}]}}, "schema": []}
{"input": "A subset of patients (n = 30) underwent multichannel pressure flow studies, which demonstrated that transrectal HIFU reduces bladder outflow obstruction.", "output": {"entities": {}}, "schema": []}
{"input": "AIMS: To establish a baseline and intraindividual fluctuations of the tumour markers CEA, CA 50 and CA 242 in patients cured from colorectal cancer, and to test the hypothesis that serum concentrations and intraindividual fluctuations do not differ from the concentrations in cancer-free individuals.", "output": {"entities": {"gene": [{"text": "CEA", "start": 85, "end": 88}, {"text": "CA 50", "start": 90, "end": 95}, {"text": "CA 242", "start": 100, "end": 106}]}}, "schema": []}
{"input": "The homologous active-site framework of these enzymes with distinct structures suggests convergent evolution of a common catalytic mechanism.", "output": {"entities": {}}, "schema": []}
{"input": "We found that RhoA can initiate a linear kinase cascade leading to the activation of ERK6 (p38 gamma), a recently identified member of the p38 family of MAPKs.", "output": {"entities": {"gene": [{"text": "RhoA", "start": 14, "end": 18}, {"text": "ERK6", "start": 85, "end": 89}, {"text": "p38 gamma", "start": 91, "end": 100}, {"text": "p38 family", "start": 139, "end": 149}]}}, "schema": []}
{"input": "We show that several heme-responsive mechanisms combine to regulate DAN/TIR gene expression.", "output": {"entities": {"gene": [{"text": "DAN", "start": 68, "end": 71}, {"text": "TIR", "start": 72, "end": 75}]}}, "schema": []}
{"input": "In strains lacking tup11 and tup12, the atf1-pcr1 transcriptional activator continues to play a central role in fbp1-lacZ expression; however, spc1 MAPK phosphorylation of atf1 is no longer essential for its activation.", "output": {"entities": {"gene": [{"text": "tup11", "start": 19, "end": 24}, {"text": "tup12", "start": 29, "end": 34}, {"text": "atf1", "start": 40, "end": 44}, {"text": "pcr1", "start": 45, "end": 49}, {"text": "fbp1", "start": 112, "end": 116}, {"text": "lacZ", "start": 117, "end": 121}, {"text": "spc1 MAPK", "start": 143, "end": 152}, {"text": "atf1", "start": 172, "end": 176}]}}, "schema": []}
{"input": "In vitro binding studies demonstrate that eIF-5A is required for efficient interaction of Rev-NES with CRM1/exportin1 and that eIF-5A interacts with the nucleoporins CAN/nup214, nup153, nup98, and nup62.", "output": {"entities": {"gene": [{"text": "eIF-5A", "start": 42, "end": 48}, {"text": "Rev", "start": 90, "end": 93}, {"text": "NES", "start": 94, "end": 97}, {"text": "CRM1", "start": 103, "end": 107}, {"text": "exportin1", "start": 108, "end": 117}, {"text": "eIF-5A", "start": 127, "end": 133}, {"text": "CAN", "start": 166, "end": 169}, {"text": "nup214", "start": 170, "end": 176}, {"text": "nup153", "start": 178, "end": 184}, {"text": "nup98", "start": 186, "end": 191}, {"text": "nup62", "start": 197, "end": 202}]}}, "schema": []}
{"input": "Structural studies have shown that class I major histocompatibility complex (MHC)-restricted peptide-specific T cell receptor (TCR)-alpha/betas make multiple contacts with the alpha1 and alpha2 helices of the MHC, but it is unclear which or how many of these interactions contribute to functional binding.", "output": {"entities": {"gene": [{"text": "class I major histocompatibility complex", "start": 35, "end": 75}, {"text": "MHC", "start": 77, "end": 80}, {"text": "T cell receptor (TCR)-alpha/betas", "start": 110, "end": 143}, {"text": "MHC", "start": 209, "end": 212}]}}, "schema": []}
{"input": "Mice homozygous for the dlg mutation exhibit growth retardation in utero, have hypoplasia of the premaxilla and mandible, have a cleft secondary palate, and die perinatally.", "output": {"entities": {"gene": [{"text": "dlg", "start": 24, "end": 27}]}}, "schema": []}
{"input": "Moreover, a complex containing PTP phi, paxillin, and a paxillin-associated tyrosine kinase, Pyk2, can be immunoprecipitated from macrophage lysates, and the catalytic domain of PTP phi selectively binds paxillin and Pyk2 in vitro.", "output": {"entities": {"gene": [{"text": "PTP phi", "start": 31, "end": 38}, {"text": "paxillin", "start": 40, "end": 48}, {"text": "paxillin-associated tyrosine kinase", "start": 56, "end": 91}, {"text": "Pyk2", "start": 93, "end": 97}, {"text": "PTP phi", "start": 178, "end": 185}, {"text": "paxillin", "start": 204, "end": 212}, {"text": "Pyk2", "start": 217, "end": 221}]}}, "schema": []}
{"input": "A single base change (A8G) in either sequence reduces hnRNP A2 binding and, in the case of A2RE-2, inhibits RNA transport.", "output": {"entities": {"gene": [{"text": "hnRNP A2", "start": 54, "end": 62}, {"text": "A2RE-2", "start": 91, "end": 97}]}}, "schema": []}
{"input": "Baseline variables associated with CD included a less frequent use of prestroke aspirin and a higher incidence of early CT changes of edema or mass effect or dense middle cerebral artery sign.", "output": {"entities": {}}, "schema": []}
{"input": "IL-1beta was significantly higher in endometrioma than in lesions of other localizations.", "output": {"entities": {"gene": [{"text": "IL-1beta", "start": 0, "end": 8}]}}, "schema": []}
{"input": "A complete drug history was compiled, specifying the amount and duration of VGB medication.", "output": {"entities": {}}, "schema": []}
{"input": "The mutant receptors, as well as sBMPR-IA, were expressed as fusion proteins with thioredoxin in Escherichia coli, and purified using reverse phase high performance liquid chromatography (RP-HPLC) after digestion with enterokinase.", "output": {"entities": {"gene": [{"text": "sBMPR-IA", "start": 33, "end": 41}, {"text": "thioredoxin", "start": 82, "end": 93}, {"text": "enterokinase", "start": 218, "end": 230}]}}, "schema": []}
{"input": "The authors undertook a retrospective analysis of pathology with quantification of the percentage of papillary serous component (% PSC) and p53 expression.", "output": {"entities": {"gene": [{"text": "p53", "start": 140, "end": 143}]}}, "schema": []}
{"input": "For this purpose, the immediate and the final (after swelling) fixation strengths of two variations of the swellable bone anchor designs (a smooth anchor and a screw anchor) were measured in two different foams (used to simulate bone) with different densities.", "output": {"entities": {}}, "schema": []}
{"input": "Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells.", "output": {"entities": {"gene": [{"text": "Smad3", "start": 57, "end": 62}, {"text": "collagen gene", "start": 93, "end": 106}]}}, "schema": []}
{"input": "Cloning and characterization of the murine beta (3) integrin gene promoter: identification of an interleukin-4 responsive element and regulation by STAT-6.", "output": {"entities": {"gene": [{"text": "murine beta (3) integrin gene", "start": 36, "end": 65}, {"text": "interleukin-4 responsive element", "start": 97, "end": 129}, {"text": "STAT-6", "start": 148, "end": 154}]}}, "schema": []}
{"input": "CONCLUSIONS: Although the levels of oxLDL antibodies might be modified in early hypertension, once advanced coronary artery disease has developed the presence of hypertension does not affect anti-oxLDL levels.", "output": {"entities": {"gene": [{"text": "oxLDL antibodies", "start": 36, "end": 52}, {"text": "anti-oxLDL", "start": 191, "end": 201}]}}, "schema": []}
{"input": "GafChromic (MD-55-2) radiochromic film has become increasingly popular for medical applications and has proven to be useful for brachytherapy dosimetry.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: Within 7 days, all groups re-acquired responding for heroin under CRF at rates similar to their pre-lesion performance.", "output": {"entities": {}}, "schema": []}
{"input": "Cis-acting CCAAT elements are frequently found in eukaryotic promoter regions.", "output": {"entities": {}}, "schema": []}
{"input": "Twenty-five patients also received PET examinations during the staging procedures.", "output": {"entities": {}}, "schema": []}
{"input": "The Gap69C is a single-copy gene producing a major 2. 1-kb mRNA throughout development, but its amount is decreased in larvae.", "output": {"entities": {"gene": [{"text": "Gap69C", "start": 4, "end": 10}]}}, "schema": []}
{"input": "Cases of lung cancer with intramedullary metastasis are rare, especially those diagnosed before death.", "output": {"entities": {}}, "schema": []}
{"input": "A novel growth-related nuclear protein binds and inhibits rat aldolase B gene promoter.", "output": {"entities": {"gene": [{"text": "aldolase B gene", "start": 62, "end": 77}]}}, "schema": []}
{"input": "OBJECTIVE: To investigate the association between complete congenital heart block (CCHB) in the fetus and adult disease.", "output": {"entities": {}}, "schema": []}
{"input": "This study examined the role of cholesteryl ester transfer (CET), cholesteryl ester transfer protein (CETP) activity, and phospholipid transfer protein (PLTP) activity in the increased prevalence of coronary artery calcification (CAC) in diabetic subjects compared with nondiabetic subjects and in the loss of the sex difference in CAC in diabetes.", "output": {"entities": {"gene": [{"text": "cholesteryl ester transfer protein", "start": 66, "end": 100}, {"text": "CETP", "start": 102, "end": 106}, {"text": "phospholipid transfer protein", "start": 122, "end": 151}, {"text": "PLTP", "start": 153, "end": 157}]}}, "schema": []}
{"input": "Two families with concordant inheritance of DNAH9 alleles in affected individuals were observed.", "output": {"entities": {"gene": [{"text": "DNAH9 alleles", "start": 44, "end": 57}]}}, "schema": []}
{"input": "Efficacy of first-generation Cavermap to verify location and function of cavernous nerves during radical prostatectomy: a multi-institutional evaluation by experienced surgeons.", "output": {"entities": {}}, "schema": []}
{"input": "The (two-motif) domain fold contains a pair of calcium binding sites very similar to those found in a two-domain prokaryotic betagamma-crystallin fold family member, Protein S.", "output": {"entities": {"gene": [{"text": "two-domain prokaryotic betagamma-crystallin fold family member", "start": 102, "end": 164}, {"text": "Protein S", "start": 166, "end": 175}]}}, "schema": []}
{"input": "Deletional analyses of VDR indicated that GRIP1 and RAC3 required an intact VDR activation function (AF-2) domain for efficient interaction as well as additional but distinct regions of the VDR.", "output": {"entities": {"gene": [{"text": "VDR", "start": 23, "end": 26}, {"text": "GRIP1", "start": 42, "end": 47}, {"text": "RAC3", "start": 52, "end": 56}, {"text": "VDR", "start": 76, "end": 79}, {"text": "VDR", "start": 190, "end": 193}]}}, "schema": []}
{"input": "Mechanism in the sequential control of cell morphology and S phase entry by epidermal growth factor involves distinct MEK/ERK activations.", "output": {"entities": {"gene": [{"text": "epidermal growth factor", "start": 76, "end": 99}, {"text": "MEK", "start": 118, "end": 121}, {"text": "ERK", "start": 122, "end": 125}]}}, "schema": []}
{"input": "3D image-processing permits to analyse ultrasound data interactively in three orthogonal planes (section mode) or in realistic 3D views (rendering mode).", "output": {"entities": {}}, "schema": []}
{"input": "Direct superoxide scavenging activity of nonsteroidal anti-inflammatory drugs: determination by electron spin resonance using the spin trap method.", "output": {"entities": {}}, "schema": []}
{"input": "BACKGROUND: Dermoscopy is a noninvasive technique that increases the diagnostic accuracy of pigmented skin lesions, particularly improving the diagnosis of patients with cutaneous melanoma in situ (CMIS) and early invasive melanoma.", "output": {"entities": {}}, "schema": []}
{"input": "Moreover, PTax expressed higher background activities than PTF, indicating that the sequence of the synthetic regulatory region can influence background levels.", "output": {"entities": {"gene": [{"text": "PTax", "start": 10, "end": 14}, {"text": "PTF", "start": 59, "end": 62}]}}, "schema": []}
{"input": "However, the promoter region contains several potential cis-regulatory elements such as Sp1, early growth response-1, activator protein-2, MyoD, p300, nuclear factor-kappaB, myeloid zinc finger protein-1, caudal-related homeobox (Cdx) gene A, and Cdx protein-2 binding sites.", "output": {"entities": {"gene": [{"text": "Sp1", "start": 88, "end": 91}, {"text": "early growth response-1", "start": 93, "end": 116}, {"text": "activator protein-2", "start": 118, "end": 137}, {"text": "MyoD", "start": 139, "end": 143}, {"text": "p300", "start": 145, "end": 149}, {"text": "nuclear factor-kappaB", "start": 151, "end": 172}, {"text": "myeloid zinc finger protein-1", "start": 174, "end": 203}, {"text": "caudal-related homeobox (Cdx) gene A", "start": 205, "end": 241}, {"text": "Cdx protein-2 binding sites", "start": 247, "end": 274}]}}, "schema": []}
{"input": "Thus, the interaction of Tat with the components of this rel/AP1 cooperative complex seems to induce quantitative and qualitative alterations of this complex as activation progresses, resulting in a decrease of IL-2 gene transcription.", "output": {"entities": {"gene": [{"text": "Tat", "start": 25, "end": 28}, {"text": "rel", "start": 57, "end": 60}, {"text": "AP1", "start": 61, "end": 64}, {"text": "IL-2 gene", "start": 211, "end": 220}]}}, "schema": []}
{"input": "2001.", "output": {"entities": {}}, "schema": []}
{"input": "Unlike other progenitor cells of the brain, SVZa progenitor cells have the capacity to divide even though they express a neuronal phenotype.", "output": {"entities": {}}, "schema": []}
{"input": "A minimal ER3 sequence of DNA was further demonstrated to function as a FXR HRE and was bound in vitro by FXR-expressing yeast extracts.", "output": {"entities": {"gene": [{"text": "FXR HRE", "start": 72, "end": 79}, {"text": "FXR", "start": 106, "end": 109}]}}, "schema": []}
{"input": "OBJECTIVE: To determine the association of depressive symptoms with HIV-related mortality and decline in CD4 lymphocyte counts among women with HIV.", "output": {"entities": {"gene": [{"text": "CD4", "start": 105, "end": 108}]}}, "schema": []}
{"input": "An economic analysis using West of Scotland Coronary Prevention Study (WOSCOPS) findings indicates that statin treatment would have prevented 318 events per 10, 000 patients in a population similar to that in WOSCOPS (average 1. 5% annual risk of a cardiovascular event) at a discounted cost per life-year gained of 20, 375 pounds ($31, 818).", "output": {"entities": {"gene": [{"text": "statin", "start": 104, "end": 110}]}}, "schema": []}
{"input": "Furthermore, the soluble forms of ATF6 and the G13 gene product are unable to bind to several point mutants of the cis-acting ER stress response element in vitro that hardly respond to ER stress in vivo.", "output": {"entities": {"gene": [{"text": "ATF6", "start": 34, "end": 38}, {"text": "G13 gene product", "start": 47, "end": 63}]}}, "schema": []}
{"input": "The present study was initiated to explore the potential of a hybrid biological reactor, combining trickling filter (TF) and activated sludge process (ASP), to treat wastewater containing trichloroethylene (TCE) at ambient temperature at different hydraulic retention time (HRT).", "output": {"entities": {}}, "schema": []}
{"input": "In DNA strand exchange reactions using oligonucleotides, we found that Rec2 exhibited a pairing bias that is opposite that of RecA.", "output": {"entities": {"gene": [{"text": "Rec2", "start": 71, "end": 75}, {"text": "RecA", "start": 126, "end": 130}]}}, "schema": []}
{"input": "Forskolin treatment (10 microM) of the transfected cells for 3--6 h maximally induced luciferase threefold.", "output": {"entities": {"gene": [{"text": "luciferase", "start": 86, "end": 96}]}}, "schema": []}
{"input": "Analysis of ace2Delta cells reveals that Ace2p is required for cell separation but not for polarized growth.", "output": {"entities": {"gene": [{"text": "Ace2p", "start": 41, "end": 46}]}}, "schema": []}
{"input": "The results presented here show that AR1 of the promoter-proximal CAP subunit was required for papBA transcription even in the absence of the histone-like protein H-NS.", "output": {"entities": {"gene": [{"text": "AR1", "start": 37, "end": 40}, {"text": "CAP subunit", "start": 66, "end": 77}, {"text": "papBA", "start": 95, "end": 100}, {"text": "histone-like protein H-NS", "start": 142, "end": 167}]}}, "schema": []}
{"input": "A., Slatkin, D.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: A significant correlation (p < 0. 001) was observed for mean wall thickness and vessel wall area between MRI and histopathology (r = 0. 87 and r = 0. 85, respectively).", "output": {"entities": {}}, "schema": []}
{"input": "Our data indicate that SIP1 is required to confine XBra gene expression to the mesoderm.", "output": {"entities": {"gene": [{"text": "SIP1", "start": 23, "end": 27}, {"text": "XBra gene", "start": 51, "end": 60}]}}, "schema": []}
{"input": "SIP1 (Smad interacting protein 1) and deltaEF1 (delta-crystallin enhancer binding factor) are structurally similar transcriptional repressors.", "output": {"entities": {"gene": [{"text": "SIP1", "start": 0, "end": 4}, {"text": "Smad interacting protein 1", "start": 6, "end": 32}, {"text": "deltaEF1", "start": 38, "end": 46}, {"text": "delta-crystallin enhancer binding factor", "start": 48, "end": 88}]}}, "schema": []}
{"input": "B-myb is essential for G1/S transition and has been shown to be phosphorylated by the cyclin A2/cdk2 complex.", "output": {"entities": {"gene": [{"text": "B-myb", "start": 0, "end": 5}, {"text": "cyclin A2", "start": 86, "end": 95}, {"text": "cdk2", "start": 96, "end": 100}]}}, "schema": []}
{"input": "Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia.", "output": {"entities": {}}, "schema": []}
{"input": "Human T-cell leukemia virus type I (HTLV-I) Tax is a potent transcriptional regulator that can activate or repress specific cellular genes and that has been proposed to contribute to leukemogenesis in adult T-cell leukemia.", "output": {"entities": {"gene": [{"text": "Human T-cell leukemia virus type I (HTLV-I) Tax", "start": 0, "end": 47}]}}, "schema": []}
{"input": "Requirements for the nuclear-cytoplasmic translocation of infected-cell protein 0 of herpes simplex virus 1.", "output": {"entities": {"gene": [{"text": "infected-cell protein 0", "start": 58, "end": 81}]}}, "schema": []}
{"input": "The Novacor Left Ventricular Assist System (LVAS) (Novacor Corp, Oakland, CA) was initially console-based and has been available since 1993 in a wearable configuration.", "output": {"entities": {}}, "schema": []}
{"input": "Atheroma appears as a very low signal intensity area on 2-dimensional time-of-flight (TOF) magnetic resonance (MR) images, and its components have various signal intensities on spin-echo (SE) images.", "output": {"entities": {}}, "schema": []}
{"input": "Body fat distribution was determined by abdominal computed tomography.", "output": {"entities": {}}, "schema": []}
{"input": "The flux rates of p-toluidine decreased as the pH value in the donor solution increased.", "output": {"entities": {}}, "schema": []}
{"input": "The protein is composed of two major domains separated by a hydrophobic linker region of 20 amino acid residues.", "output": {"entities": {}}, "schema": []}
{"input": "We performed the present study to clarify the relationship between the DOX binding ability (% DB) and the histologic response, rate of decrease in tumor volume of malignant soft tissue tumors after preoperative chemotherapy and prognosis.", "output": {"entities": {}}, "schema": []}
{"input": "To avoid misinterpretations, special reference values should be applied for preadolescents, at least with regard to FVC and FEV1.", "output": {"entities": {}}, "schema": []}
{"input": "Nephrotoxicity after orthotopic liver transplantation in cyclosporin A and FK 506-treated patients.", "output": {"entities": {}}, "schema": []}
{"input": "Compared with normal control subjects, all 74 TOF patients had decreased systolic and diastolic myocardial velocities and a longer isovolumic relaxation time.", "output": {"entities": {}}, "schema": []}
{"input": "Acetoin can be reused by the bacteria during stationary phase when other carbon sources have been depleted.", "output": {"entities": {}}, "schema": []}
{"input": "Mutational analysis showed that the U-box, like the RING finger in other proteins, forms the physical basis for the interaction with E2 enzymes.", "output": {"entities": {"gene": [{"text": "E2 enzymes", "start": 133, "end": 143}]}}, "schema": []}
{"input": "Thus, our studies define Rac/Cdc42/Pak as a module upstream of Raf-1 during its activation by microtubule disruption.", "output": {"entities": {"gene": [{"text": "Rac", "start": 25, "end": 28}, {"text": "Cdc42", "start": 29, "end": 34}, {"text": "Pak", "start": 35, "end": 38}, {"text": "Raf-1", "start": 63, "end": 68}]}}, "schema": []}
{"input": "Nrf2 regulates expression of genes encoding enzymes with antioxidant (e. g. heme oxygenase-1 (HO-1)) or xenobiotic detoxification (e. g.", "output": {"entities": {"gene": [{"text": "Nrf2", "start": 0, "end": 4}, {"text": "heme oxygenase-1", "start": 76, "end": 92}, {"text": "HO-1", "start": 94, "end": 98}]}}, "schema": []}
{"input": "These results indicate that ATF4 regulates basal and CdCl (2)-induced expression of the ho-1 gene in a cell-specific manner and possibly in a complex with Nrf2.", "output": {"entities": {"gene": [{"text": "ATF4", "start": 28, "end": 32}, {"text": "ho-1 gene", "start": 88, "end": 97}, {"text": "Nrf2", "start": 155, "end": 159}]}}, "schema": []}
{"input": "On the other hand, forced overexpression of the wild type, but not the kinase-inactivated mutant of nm23H1, converted the GDP-bound forms of Rac1, Cdc42, and RhoA to their GTP-bound forms in vitro by its nucleoside diphosphate kinase activity, but nm23H1 alone apparently did not produce the GTP-bound form of these GTPases in vivo.", "output": {"entities": {"gene": [{"text": "nm23H1", "start": 100, "end": 106}, {"text": "Rac1", "start": 141, "end": 145}, {"text": "Cdc42", "start": 147, "end": 152}, {"text": "RhoA", "start": 158, "end": 162}, {"text": "nucleoside diphosphate kinase", "start": 204, "end": 233}, {"text": "nm23H1", "start": 248, "end": 254}, {"text": "GTPases", "start": 316, "end": 323}]}}, "schema": []}
{"input": "This effect was observed in the absence of de novo protein synthesis and was independent of histone deacetylase activity.", "output": {"entities": {"gene": [{"text": "histone deacetylase", "start": 92, "end": 111}]}}, "schema": []}
{"input": "Deletion of the potential initiator element does not affect repression of the p21 promoter by c-Myc.", "output": {"entities": {"gene": [{"text": "p21 promoter", "start": 78, "end": 90}, {"text": "c-Myc", "start": 94, "end": 99}]}}, "schema": []}
{"input": "Fetal lung volume: estimation at MR imaging-initial results.", "output": {"entities": {}}, "schema": []}
{"input": "Of its gene products, E6 binds to and inactivates p53 tumor suppressor protein by ubiquitin/proteasome-dependent degradation.", "output": {"entities": {"gene": [{"text": "E6", "start": 22, "end": 24}, {"text": "p53 tumor suppressor protein", "start": 50, "end": 78}, {"text": "ubiquitin", "start": 82, "end": 91}]}}, "schema": []}
{"input": "In mouse, Mmip1 (Mad member interacting protein 1) and Smc3 share 99% sequence identity and are products of the same gene.", "output": {"entities": {"gene": [{"text": "Mmip1", "start": 10, "end": 15}, {"text": "Mad member interacting protein 1", "start": 17, "end": 49}, {"text": "Smc3", "start": 55, "end": 59}]}}, "schema": []}
{"input": "An element within the 5' untranslated region of human Hsp70 mRNA which acts as a general enhancer of mRNA translation.", "output": {"entities": {"gene": [{"text": "human Hsp70 mRNA", "start": 48, "end": 64}]}}, "schema": []}
{"input": "In SN-48 neuronal cells that express MR, GR, and 5-HT1A receptors, deletion or inactivation of the nGRE (negative GRE) eliminated negative regulation of the rat 5-HT1A or heterologous promoters by corticosteroids, whereas its inclusion conferred corticosteroid-induced inhibition to a heterologous promoter.", "output": {"entities": {"gene": [{"text": "MR", "start": 37, "end": 39}, {"text": "GR", "start": 41, "end": 43}, {"text": "5-HT1A receptors", "start": 49, "end": 65}, {"text": "rat 5-HT1A", "start": 157, "end": 167}]}}, "schema": []}
{"input": "Corticosteroid-mediated transcriptional inhibition was greater for MR/GR in combination than for MR or GR alone.", "output": {"entities": {"gene": [{"text": "MR", "start": 67, "end": 69}, {"text": "GR", "start": 70, "end": 72}, {"text": "MR", "start": 97, "end": 99}, {"text": "GR", "start": 103, "end": 105}]}}, "schema": []}
{"input": "Whereas Smad2 was rapidly phosphorylated by TGF-beta and involved in the initial activation of Agc expression in confluent cells, Smad2 activation was not required for maintaining the high level of Agc expression.", "output": {"entities": {"gene": [{"text": "Smad2", "start": 8, "end": 13}, {"text": "TGF-beta", "start": 44, "end": 52}, {"text": "Agc", "start": 95, "end": 98}, {"text": "Smad2", "start": 130, "end": 135}, {"text": "Agc", "start": 198, "end": 201}]}}, "schema": []}
{"input": "Reverse transcriptase-polymerase chain reaction assays showed that PKRDeltaE7 is expressed in a broad range of human tissues at variable levels.", "output": {"entities": {"gene": [{"text": "Reverse transcriptase", "start": 0, "end": 21}, {"text": "PKRDeltaE7", "start": 67, "end": 77}]}}, "schema": []}
{"input": "Both pancreatic and intestinal cell lines were found to express a number of POU (OCT binding) homeodomain proteins examined by electrophoretic mobility shift assay.", "output": {"entities": {"gene": [{"text": "POU", "start": 76, "end": 79}, {"text": "OCT", "start": 81, "end": 84}]}}, "schema": []}
{"input": "SV1 has a 33-amino acid insert in the S1 transmembrane domain that does not alter S1 overall hydrophobicity, but makes the S0-S1 linker longer.", "output": {"entities": {"gene": [{"text": "SV1", "start": 0, "end": 3}]}}, "schema": []}
{"input": "Polyclonal antibodies against the N-terminal part (amino acids 12-363) and the C-terminal part (amino acids 330-730) of rainbow trout HIF-1alpha protein recognized rainbow trout and chinook salmon HIF-1alpha protein in Western blot analysis.", "output": {"entities": {"gene": [{"text": "rainbow trout HIF-1alpha protein", "start": 120, "end": 152}, {"text": "rainbow trout and chinook salmon HIF-1alpha protein", "start": 164, "end": 215}]}}, "schema": []}
{"input": "The v-Src SH3 domain facilitates a cell adhesion-independent association with focal adhesion kinase.", "output": {"entities": {"gene": [{"text": "v-Src SH3 domain", "start": 4, "end": 20}, {"text": "focal adhesion kinase", "start": 78, "end": 99}]}}, "schema": []}
{"input": "Mutagenesis of SNT1 (IRS) CX identified three classes of effector motifs within SNT critical for both sustained ERK activation and neuronal differentiation: 1) four phosphotyrosine motifs that mediate recruitment of Grb2, 2) two phosphotyrosine motifs that mediate recruitment of Shp2, and 3) a C-terminal motif that functions by helping to recruit Sos.", "output": {"entities": {"gene": [{"text": "SNT1", "start": 15, "end": 19}, {"text": "IRS", "start": 21, "end": 24}, {"text": "CX", "start": 26, "end": 28}, {"text": "SNT", "start": 80, "end": 83}, {"text": "ERK", "start": 112, "end": 115}, {"text": "Grb2", "start": 216, "end": 220}, {"text": "Shp2", "start": 280, "end": 284}, {"text": "Sos", "start": 349, "end": 352}]}}, "schema": []}
{"input": "Exchanging the human propeptide in this chimera with either the murine MIC-1 or TGF-beta1 propeptide resulted in secretion of the unprocessed, monomeric chimera, suggesting a specific interaction between the human MIC-1 propeptide and mature peptide.", "output": {"entities": {"gene": [{"text": "murine MIC-1", "start": 64, "end": 76}, {"text": "TGF-beta1 propeptide", "start": 80, "end": 100}, {"text": "human MIC-1 propeptide", "start": 208, "end": 230}]}}, "schema": []}
{"input": "Radiolabeled biantennary N-glycans synthesized by Pro (-) 5Lec20 were proportionately less ricin-bound than similar species from parental CHO cells, and Lec20 cell extracts had a markedly reduced ability to transfer Gal to GlcNAc-terminating acceptors.", "output": {"entities": {}}, "schema": []}
{"input": "We found that the SOCS box interacted with Cullin-2 and promoted ubiquitination of TEL-JAK2.", "output": {"entities": {"gene": [{"text": "SOCS box", "start": 18, "end": 26}, {"text": "Cullin-2", "start": 43, "end": 51}, {"text": "TEL", "start": 83, "end": 86}, {"text": "JAK2", "start": 87, "end": 91}]}}, "schema": []}
{"input": "Neuron-specific Bcl-2 homology 3 domain-only splice variant of Bak is anti-apoptotic in neurons, but pro-apoptotic in non-neuronal cells.", "output": {"entities": {"gene": [{"text": "Neuron-specific Bcl-2 homology 3 domain-only splice variant", "start": 0, "end": 59}, {"text": "Bak", "start": 63, "end": 66}]}}, "schema": []}
{"input": "Sequence comparison and binding studies of the 18-bp MOK2-binding sites present in intron 2 of human, bovine, and mouse IRBP genes show that the 3'-half sequence is the essential core element for MOK2 binding.", "output": {"entities": {"gene": [{"text": "18-bp MOK2-binding sites", "start": 47, "end": 71}, {"text": "mouse IRBP genes", "start": 114, "end": 130}, {"text": "MOK2", "start": 196, "end": 200}]}}, "schema": []}
{"input": "Furthermore, SB203580 inhibited LPS-induced activation of Sp1, as well as the promoter activity in cells transfected with a plasmid containing the Sp1 consensus sequence.", "output": {"entities": {"gene": [{"text": "Sp1", "start": 58, "end": 61}, {"text": "Sp1", "start": 147, "end": 150}]}}, "schema": []}
{"input": "We confirmed the interaction between TLS and p65 by the pull-down assay in vitro and by a coimmunoprecipitation experiment followed by Western blot of the cultured cell in vivo.", "output": {"entities": {"gene": [{"text": "TLS", "start": 37, "end": 40}, {"text": "p65", "start": 45, "end": 48}]}}, "schema": []}
{"input": "Based on mutational data and possible mRNA structure, we hypothesized about the effect of mRNA structure on translation of the two major C/EBPepsilon isoforms: p32 and p30.", "output": {"entities": {"gene": [{"text": "C/EBPepsilon isoforms", "start": 137, "end": 158}, {"text": "p32", "start": 160, "end": 163}, {"text": "p30", "start": 168, "end": 171}]}}, "schema": []}
{"input": "Binding of serum response factor to CArG box sequences is necessary but not sufficient to restrict gene expression to arterial smooth muscle cells.", "output": {"entities": {"gene": [{"text": "serum response factor", "start": 11, "end": 32}]}}, "schema": []}
{"input": "Together, these results identify HPK1 as a new component of TCR signaling.", "output": {"entities": {"gene": [{"text": "HPK1", "start": 33, "end": 37}, {"text": "TCR", "start": 60, "end": 63}]}}, "schema": []}
{"input": "The size of the infarct was determined using the creatine kinase integral method.", "output": {"entities": {"gene": [{"text": "creatine kinase", "start": 49, "end": 64}]}}, "schema": []}
{"input": "A new echocardiographic technique is described with a conventional M mode, digitalised 2D and tissular Doppler which has a comparable ability to identify the anomalous pathways of electric conduction using a non-invasive method.", "output": {"entities": {}}, "schema": []}
{"input": "SELECTION CRITERIA: Randomised controlled trials of cabergoline versus placebo in patients with a clinical diagnosis of idiopathic Parkinson' s disease and long-term complications of levodopa therapy.", "output": {"entities": {}}, "schema": []}
{"input": "Deterministic effects.", "output": {"entities": {}}, "schema": []}
{"input": "Unusual two-domain arginine kinases (AKs) arose independently at least two times during molecular evolution of phosphagen kinases: AKs from the primitive sea anemone Anthopleurura japonicus and from the clam Pseudocardium sachalinensis.", "output": {"entities": {"gene": [{"text": "two-domain arginine kinases", "start": 8, "end": 35}, {"text": "AKs", "start": 37, "end": 40}, {"text": "phosphagen kinases", "start": 111, "end": 129}, {"text": "AKs", "start": 131, "end": 134}]}}, "schema": []}
{"input": "The mouse platelet-derived growth factor (PDGF) beta-receptor promoter contains a CCAAT motif, and NF-Y plays an essential role in its transcription.", "output": {"entities": {"gene": [{"text": "mouse platelet-derived growth factor (PDGF) beta-receptor promoter", "start": 4, "end": 70}, {"text": "NF-Y", "start": 99, "end": 103}]}}, "schema": []}
{"input": "Baseline MBF in females was significantly (P < 0. 001) higher than in males.", "output": {"entities": {}}, "schema": []}
{"input": "No preferential VH/VL-chains correlated with any of the 12 different antigen reactivities, even for mAbs with nearly identical cross-reactivities.", "output": {"entities": {"gene": [{"text": "VH", "start": 16, "end": 18}, {"text": "VL", "start": 19, "end": 21}]}}, "schema": []}
{"input": "Recently, it was shown that purified RAG1/2 proteins can cleave DNA hairpins in vitro, but the same activity was also described for a protein complex of the DNA repair proteins Nbs1/Mre11/Rad50.", "output": {"entities": {"gene": [{"text": "RAG1/2 proteins", "start": 37, "end": 52}, {"text": "Nbs1", "start": 177, "end": 181}, {"text": "Mre11", "start": 182, "end": 187}, {"text": "Rad50", "start": 188, "end": 193}]}}, "schema": []}
{"input": "In addition, we did not detect significant differences in CDR3 sequences of endogenous Ig lambdaL and kappaL chain gene loci cloned from peripheral blood lymphocytes of an NBS patient and of healthy individuals.", "output": {"entities": {"gene": [{"text": "CDR3 sequences", "start": 58, "end": 72}, {"text": "endogenous Ig lambdaL", "start": 76, "end": 97}, {"text": "kappaL chain gene loci", "start": 102, "end": 124}]}}, "schema": []}
{"input": "Phase II study of paclitaxel and oral etoposide in patients with locally advanced or metastatic non-small cell lung cancer.", "output": {"entities": {}}, "schema": []}
{"input": "Oral supplementation of L-arginine significantly increased plasma L-citrulline, which indicated enhancement of NO production.", "output": {"entities": {}}, "schema": []}
{"input": "This activation was then blocked by CGS 12066A.", "output": {"entities": {}}, "schema": []}
{"input": "Two independent transgenic lines were produced, and both showed expression of the Gus gene specifically in the endosperm during mid-development (first detected 10-12 d after anthesis).", "output": {"entities": {"gene": [{"text": "Gus gene", "start": 82, "end": 90}]}}, "schema": []}
{"input": "Here we demonstrate that native MRCK exists in high-molecular-weight complexes.", "output": {"entities": {"gene": [{"text": "native MRCK", "start": 25, "end": 36}]}}, "schema": []}
{"input": "Regression analyses showed that SOREMP dream occurrences were significantly related to the amount of REM sleep, while NREMP dream occurrences were related to arousals from NREM sleep.", "output": {"entities": {}}, "schema": []}
{"input": "Instead, TRPS1 potently and specifically represses transcriptional activation mediated by other GATA factors.", "output": {"entities": {"gene": [{"text": "TRPS1", "start": 9, "end": 14}, {"text": "GATA factors", "start": 96, "end": 108}]}}, "schema": []}
{"input": "9. 7 (95% CI: 9. 6-9. 7) micromol/L among women (P = 0. 003).", "output": {"entities": {}}, "schema": []}
{"input": "Three patients received additional cycles of 5-fluorouracil +/-leucovorin as maintenance chemotherapy. RESULTS: Thirty males and 21 females with a median age of 55 years (range 31--73 years) were treated.", "output": {"entities": {}}, "schema": []}
{"input": "Secretion of interleukin-8, RANTES, macrophage inflammatory protein 1alpha, and 10-kappaDa IFN-gamma-inducible protein were increased in differentiating keratinocytes by E6.", "output": {"entities": {"gene": [{"text": "interleukin-8", "start": 13, "end": 26}, {"text": "RANTES", "start": 28, "end": 34}, {"text": "macrophage inflammatory protein 1alpha", "start": 36, "end": 74}, {"text": "10-kappaDa IFN-gamma-inducible protein", "start": 80, "end": 118}, {"text": "E6", "start": 170, "end": 172}]}}, "schema": []}
{"input": "Another mutant, T255A, lost the ability to bind E4orf6, but unexpectedly, viral late-gene expression was not affected.", "output": {"entities": {"gene": [{"text": "E4orf6", "start": 48, "end": 54}]}}, "schema": []}
{"input": "Herein PPARgamma, liganded by either natural (15d-PGJ (2) and PGD (2)) or synthetic ligands (BRL49653 and troglitazone), selectively inhibited expression of the cyclin D1 gene.", "output": {"entities": {"gene": [{"text": "PPARgamma", "start": 7, "end": 16}, {"text": "cyclin D1 gene", "start": 161, "end": 175}]}}, "schema": []}
{"input": "Here we demonstrate that the Ras-activated Raf-MEK-extracellular signal-regulated kinase (ERK) signaling pathway can specifically control the expression of individual integrin subunits in a variety of human and mouse cell lines.", "output": {"entities": {"gene": [{"text": "Ras", "start": 29, "end": 32}, {"text": "Raf", "start": 43, "end": 46}, {"text": "MEK", "start": 47, "end": 50}, {"text": "extracellular signal-regulated kinase", "start": 51, "end": 88}, {"text": "ERK", "start": 90, "end": 93}, {"text": "integrin subunits", "start": 167, "end": 184}]}}, "schema": []}
{"input": "Children who developed lower respiratory tract infections or PCP had increased rates of decline of CD4 cell counts during the first 6 months of life.", "output": {"entities": {"gene": [{"text": "CD4", "start": 99, "end": 102}]}}, "schema": []}
{"input": "The reproductive effects of the administration of 4-chloro-2-methylphenoxyacetic acid (MCPA) to rats were evaluated through two generations, from prior to mating, throughout mating, to gestation and lactation.", "output": {"entities": {}}, "schema": []}
{"input": "Coexposure to FP also resulted in a more pronounced and sustained activation of the mitogen-activated protein kinase kinase/extracellular signal-regulated protein kinase cascade after PMA treatment, although disruption of this pathway by the mitogen-activated protein kinase kinase 1 inhibitor U0126 did not prevent potentiation of apoptosis.", "output": {"entities": {"gene": [{"text": "mitogen-activated protein kinase kinase", "start": 84, "end": 123}, {"text": "extracellular signal-regulated protein kinase", "start": 124, "end": 169}, {"text": "mitogen-activated protein kinase kinase 1", "start": 242, "end": 283}]}}, "schema": []}
{"input": "Also, the EWS protein stimulates transcription mediated by the COOH-terminal transactivation domain of the cofactor CREB-binding protein (CBP).", "output": {"entities": {"gene": [{"text": "EWS protein", "start": 10, "end": 21}, {"text": "CREB-binding protein", "start": 116, "end": 136}, {"text": "CBP", "start": 138, "end": 141}]}}, "schema": []}
{"input": "In the present study, we have determined the ICBP90 gene structure by screening of a human placenta genomic library and PCR analysis.", "output": {"entities": {"gene": [{"text": "ICBP90 gene", "start": 45, "end": 56}]}}, "schema": []}
{"input": "Tumor-like accumulation on Tl-201 SPECT in subacute hemorrhagic cerebral infarction.", "output": {"entities": {}}, "schema": []}
{"input": "METHODS: 126 patients with histologically confirmed MFH were analyzed.", "output": {"entities": {}}, "schema": []}
{"input": "It is surprising that dnaE173, a potent mutator mutation specific for sequence substitution as well as single-base frameshift, did not enhance the frequency of the hot-spot frameshift mutation.", "output": {"entities": {}}, "schema": []}
{"input": "Its transcription in vitro by pol III requires the same factors as the U6 gene with the major exception that the modified TATA-box of this construct only interacts with a TATA-binding protein (TBP) mutant (TBP-DR2) but not with TBP wild-type (TBPwt).", "output": {"entities": {"gene": [{"text": "pol III", "start": 30, "end": 37}, {"text": "U6 gene", "start": 71, "end": 78}, {"text": "TATA-binding protein", "start": 171, "end": 191}, {"text": "TBP", "start": 193, "end": 196}, {"text": "TBP-DR2", "start": 206, "end": 213}, {"text": "TBP wild-type", "start": 228, "end": 241}, {"text": "TBPwt", "start": 243, "end": 248}]}}, "schema": []}
{"input": "HSF binds DNA as a trimer, and additional trimers can bind DNA co-operatively.", "output": {"entities": {"gene": [{"text": "HSF", "start": 0, "end": 3}]}}, "schema": []}
{"input": "We also demonstrate that the spo20 (+) gene product is structurally homologous to Saccharomyces cerevisiae Sec14, the major phosphatidylinositol transfer protein of budding yeast.", "output": {"entities": {"gene": [{"text": "spo20 (+) gene product", "start": 29, "end": 51}, {"text": "Saccharomyces cerevisiae Sec14", "start": 82, "end": 112}]}}, "schema": []}
{"input": "There was no evidence of linkage disequilibrium between the polymorphic site in the B cell specific promoter and those in the 3' UTR.", "output": {"entities": {}}, "schema": []}
{"input": "Their numbers have regularly increased since the mid-1970s.", "output": {"entities": {}}, "schema": []}
{"input": "Specimen mass reduction increased with irradiance from 19 to 72% of the initial mass for 9--31 W/cm (2), respectively.", "output": {"entities": {}}, "schema": []}
{"input": "In conclusion, tube size estimated by Cole' s formula tends to be smaller than practically appropriate tube size for pediatric cardiac anesthesia, and therefore we suggest new formula to estimate the tube size.", "output": {"entities": {}}, "schema": []}
{"input": "An F222W: W21F rGST A1-1 double mutant provides a direct fluorescence probe of changes in the environment of the C-terminal residue.", "output": {"entities": {"gene": [{"text": "F222W: W21F rGST A1-1 double mutant", "start": 3, "end": 38}]}}, "schema": []}
{"input": "The recessive hos1 mutation causes enhanced induction of the CBF transcription factors by low temperature as well as of their downstream cold-responsive genes.", "output": {"entities": {"gene": [{"text": "hos1", "start": 14, "end": 18}, {"text": "CBF transcription factors", "start": 61, "end": 86}]}}, "schema": []}
{"input": "Stable transfection of human CHOP cDNA into mammary carcinoma cells demonstrated that CHOP functioned not as a mediator of hGH-stimulated mitogenesis but rather enhanced the protection from apoptosis afforded by hGH in a p38 MAPK-dependent manner.", "output": {"entities": {"gene": [{"text": "human CHOP cDNA", "start": 23, "end": 38}, {"text": "CHOP", "start": 86, "end": 90}, {"text": "hGH", "start": 123, "end": 126}, {"text": "hGH", "start": 212, "end": 215}, {"text": "p38", "start": 221, "end": 224}]}}, "schema": []}
{"input": "A comparison of the duplicated Vkappa genes suggests positive selection on the complementarity-determining regions of the duplicated genes by point mutations.", "output": {"entities": {"gene": [{"text": "Vkappa genes", "start": 31, "end": 43}]}}, "schema": []}
{"input": "In contrast, the ubiquitous expression of p19 (INK4d) has not been previously described in human or murine B-lineage cells.", "output": {"entities": {"gene": [{"text": "p19", "start": 42, "end": 45}, {"text": "INK4d", "start": 47, "end": 52}]}}, "schema": []}
{"input": "The results show that cognitive stimulation enhanced performance on the Boston Naming Test and a Word List Recognition Task; physical intervention, however, did not reach statistical significance.", "output": {"entities": {}}, "schema": []}
{"input": "Instead, affective flattening was associated with both dopamine receptor sensitivity and psychomotor slowing.", "output": {"entities": {"gene": [{"text": "dopamine receptor", "start": 55, "end": 72}]}}, "schema": []}
{"input": "Homo-oligomerisation and nuclear localisation of mouse histone deacetylase 1.", "output": {"entities": {"gene": [{"text": "mouse histone deacetylase 1", "start": 49, "end": 76}]}}, "schema": []}
{"input": "With NEU overexpression, nodal control decreased from 72% to 34% (p =. 008).", "output": {"entities": {"gene": [{"text": "NEU", "start": 5, "end": 8}]}}, "schema": []}
{"input": "At the time of the blind therapeutic doses, Tg-off values ranged from 8 to 608 microg/l.", "output": {"entities": {"gene": [{"text": "Tg", "start": 44, "end": 46}]}}, "schema": []}
{"input": "Effects of a booster dose of tetanus toxoid after different primary courses of vaccination: implications on the use of immune globulin.", "output": {"entities": {"gene": [{"text": "immune globulin", "start": 119, "end": 134}]}}, "schema": []}
{"input": "Using RACE techniques we have cloned and sequenced one of the hamster liver 3-hydroxy-hexobarbital dehydrogenases which catalyze not only cyclic alcohols but also 17beta-hydroxy-steroids and 3alpha-hydroxysteroids.", "output": {"entities": {"gene": [{"text": "3-hydroxy-hexobarbital dehydrogenases", "start": 76, "end": 113}]}}, "schema": []}
{"input": "An association was demonstrated between the expression of aberrantly and/or alternatively spliced mdm2 mRNAs and a lack of progesterone receptor.", "output": {"entities": {"gene": [{"text": "mdm2 mRNAs", "start": 98, "end": 108}, {"text": "progesterone receptor", "start": 123, "end": 144}]}}, "schema": []}
{"input": "Histological examination showed lichenoid changes, acantholytic blister formation and apoptotic keratinocytes.", "output": {"entities": {}}, "schema": []}
{"input": "We find that our response function is well approximated by the GSER only within a particular frequency range determined by the material parameters of both the bead and the network.", "output": {"entities": {}}, "schema": []}
{"input": "It is shown that, for any periodic input, the map representing the relation between input phases at consecutive discharge times can be restricted to a piecewise continuous, orientation preserving circle map.", "output": {"entities": {}}, "schema": []}
{"input": "Nine strains were subtyped as Camp. jejuni subsp. jejuni biotype II and the remaining ones as biotype I.", "output": {"entities": {}}, "schema": []}
{"input": "Analysis of mCTR mRNAs has revealed that the three alternative promoters give rise to at least seven mCTR isoforms in the 5' region of the gene and generate 5'-untranslated regions of very different lengths.", "output": {"entities": {"gene": [{"text": "mCTR mRNAs", "start": 12, "end": 22}, {"text": "mCTR isoforms", "start": 101, "end": 114}]}}, "schema": []}
{"input": "Effects of 3' terminus modifications on mRNA functional decay during in vitro protein synthesis.", "output": {"entities": {}}, "schema": []}
{"input": "A comprehensive neuropsychological battery was administered to 48 veterans with Gulf War Illness (GWI) characterized by severe fatigue (GV-F) and 39 healthy veterans (GV-H).", "output": {"entities": {}}, "schema": []}
{"input": "Reverse transcription-PCR analysis of mRNA from patients shows that each of these five mutations results in aberrant splicing.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: Coronary mortality during the median follow-up time of 17 months was 6-fold higher in the highest tertile for CRP and IL-6 and 3. 5-fold higher in the highest tertile for fibrinogen and TNF-alpha than in the respective combined lower tertiles.", "output": {"entities": {"gene": [{"text": "CRP", "start": 119, "end": 122}, {"text": "IL-6", "start": 127, "end": 131}, {"text": "fibrinogen", "start": 180, "end": 190}, {"text": "TNF-alpha", "start": 195, "end": 204}]}}, "schema": []}
{"input": "The relationship of the factor V Leiden mutation or the deletion-deletion polymorphism of the angiotensin converting enzyme to postoperative thromboembolic events following total joint arthroplasty.", "output": {"entities": {"gene": [{"text": "factor V Leiden mutation", "start": 24, "end": 48}, {"text": "angiotensin converting enzyme", "start": 94, "end": 123}]}}, "schema": []}
{"input": "To examine transcriptional regulation of the rat eIF4E gene, 2. 1 kB of the rat eIF4E promoter region was cloned and the contribution of specific elements in regulating transcription was determined in primary cultures of rat cardiocytes and in a murine C (2) C (12) myoblast cell line.", "output": {"entities": {"gene": [{"text": "rat eIF4E gene", "start": 45, "end": 59}, {"text": "rat eIF4E promoter region", "start": 76, "end": 101}]}}, "schema": []}
{"input": "In the remaining case, the aneurysm originated from the proximal end of the associated A1 fenestration.", "output": {"entities": {}}, "schema": []}
{"input": "GABA (B) R1g was expressed in both brain and peripheral tissues.", "output": {"entities": {"gene": [{"text": "GABA (B) R1g", "start": 0, "end": 12}]}}, "schema": []}
{"input": "Raes, P.", "output": {"entities": {}}, "schema": []}
{"input": "NF-kappaB pathway activation occurs during transformation induced by a number of classical oncogenes, including Bcr/Abl, Ras and Rac, and is necessary for full transforming potential.", "output": {"entities": {"gene": [{"text": "NF-kappaB", "start": 0, "end": 9}, {"text": "Bcr", "start": 112, "end": 115}, {"text": "Abl", "start": 116, "end": 119}, {"text": "Ras", "start": 121, "end": 124}, {"text": "Rac", "start": 129, "end": 132}]}}, "schema": []}
{"input": "We used a rev-and RRE-defective HIV type 1 (HIV-1) molecular clone in complementation experiments to establish a method for the rapid isolation of posttranscriptional regulatory elements from the mammalian genome by selecting for rescue of virus replication.", "output": {"entities": {"gene": [{"text": "rev", "start": 10, "end": 13}, {"text": "RRE", "start": 18, "end": 21}]}}, "schema": []}
{"input": "Copyright 2001 Academic Press.", "output": {"entities": {}}, "schema": []}
{"input": "A novel myeloid-restricted zebrafish CCAAT/enhancer-binding protein with a potent transcriptional activation domain.", "output": {"entities": {"gene": [{"text": "CCAAT/enhancer-binding protein", "start": 37, "end": 67}]}}, "schema": []}
{"input": "Recently, we discovered that alanine substitutions of the active center cleft residues significantly impair the depurinating and ribosome inhibitory activity of PAP.", "output": {"entities": {"gene": [{"text": "PAP", "start": 161, "end": 164}]}}, "schema": []}
{"input": "SH2D1A protein levels are up-regulated by CD40 cross-linking and down-regulated by B cell receptor ligation.", "output": {"entities": {"gene": [{"text": "SH2D1A protein", "start": 0, "end": 14}, {"text": "CD40", "start": 42, "end": 46}, {"text": "B cell receptor", "start": 83, "end": 98}]}}, "schema": []}
{"input": "Cross-linking FcalphaR on wt-ITAM or IIA-ITAM cells triggered equivalent PI 3-kinase-dependent activation of PKBalpha.", "output": {"entities": {"gene": [{"text": "FcalphaR", "start": 14, "end": 22}, {"text": "wt-ITAM", "start": 26, "end": 33}, {"text": "IIA-ITAM", "start": 37, "end": 45}, {"text": "PI 3-kinase", "start": 73, "end": 84}, {"text": "PKBalpha", "start": 109, "end": 117}]}}, "schema": []}
{"input": "RPM/RGL3 resembled AF-6 and Nore1 in interacting strongly with constitutively active M-Ras and p21 Ras.", "output": {"entities": {"gene": [{"text": "RPM", "start": 0, "end": 3}, {"text": "RGL3", "start": 4, "end": 8}, {"text": "AF-6", "start": 19, "end": 23}, {"text": "Nore1", "start": 28, "end": 33}, {"text": "M-Ras", "start": 85, "end": 90}, {"text": "p21 Ras", "start": 95, "end": 102}]}}, "schema": []}
{"input": "A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.", "output": {"entities": {"gene": [{"text": "M-Ras", "start": 30, "end": 35}, {"text": "p21 Ras", "start": 40, "end": 47}, {"text": "p21 Ras", "start": 69, "end": 76}]}}, "schema": []}
{"input": "The mice are phenotypically normal and do not develop spontaneous tumors at an early age, in contrast to knock-out (p53 (-/-)) strains with a defective p53 gene.", "output": {"entities": {"gene": [{"text": "p53 (-/-)", "start": 116, "end": 125}, {"text": "p53 gene", "start": 152, "end": 160}]}}, "schema": []}
{"input": "Cyclins are one of the pivotal determinants regulating cell cycle progression.", "output": {"entities": {"gene": [{"text": "Cyclins", "start": 0, "end": 7}]}}, "schema": []}
{"input": "Evidence-based care: a new formula for an old problem?", "output": {"entities": {}}, "schema": []}
{"input": "Further, the osteo-retentive ability of the hydroxyapatite in the sockets was seen to be close to significance (after six months width differences, in the canine region: P = 0. 059, LHS, and P = 0. 065, RHS).", "output": {"entities": {}}, "schema": []}
{"input": "The cleavage site between VPg and RNA dependent RNA polymerase was predicted to be E445-T446 based on the amino acid sequence analysis of the polyprotein from different sobemoviruses.", "output": {"entities": {"gene": [{"text": "VPg", "start": 26, "end": 29}, {"text": "RNA dependent RNA polymerase", "start": 34, "end": 62}]}}, "schema": []}
{"input": "The% SVend of HCM-I was significantly lower than the respective values of the HCM-II and Control groups.", "output": {"entities": {}}, "schema": []}
{"input": "Nearly all isolates of S. intermedius and most isolates of S. constellatus, but only 19% of those of S. anginosus, were associated with abscess.", "output": {"entities": {}}, "schema": []}
{"input": "DESIGN: Retrospective study.", "output": {"entities": {}}, "schema": []}
{"input": "Human brain cDNA library screening and 5' rapid amplification of cDNA ends yielded full-length DENTT cDNA containing an 1899-bp open reading frame encoding a predicted 633-amino-acid protein with four potential nuclear localization signals (NLSs) and two coiled-coil regions.", "output": {"entities": {"gene": [{"text": "full-length DENTT cDNA", "start": 83, "end": 105}]}}, "schema": []}
{"input": "Transfection of EGFP-tagged DENTT NLS deletion constructs lacking the bipartite NLS-1 were excluded from the nucleolus.", "output": {"entities": {"gene": [{"text": "EGFP", "start": 16, "end": 20}, {"text": "DENTT", "start": 28, "end": 33}, {"text": "NLS-1", "start": 80, "end": 85}]}}, "schema": []}
{"input": "These genes encode a tryptophanyl tRNA, the protein translocase component SecE, the antiterminator protein NusG, and the ribosomal proteins L11 and L1 in addition to PkwR, a putative regulatory protein of the LacI-GalR family.", "output": {"entities": {"gene": [{"text": "tryptophanyl tRNA", "start": 21, "end": 38}, {"text": "protein translocase", "start": 44, "end": 63}, {"text": "SecE", "start": 74, "end": 78}, {"text": "antiterminator protein NusG", "start": 84, "end": 111}, {"text": "L11", "start": 140, "end": 143}, {"text": "L1", "start": 148, "end": 150}, {"text": "PkwR", "start": 166, "end": 170}, {"text": "LacI", "start": 209, "end": 213}, {"text": "GalR", "start": 214, "end": 218}]}}, "schema": []}
{"input": "Rapamycin (FRAP/mTOR inhibitor) blocked 4E-BP1 phosphorylation causing a predominance of the alpha (hypophosphorylated) band.", "output": {"entities": {"gene": [{"text": "FRAP", "start": 11, "end": 15}, {"text": "mTOR", "start": 16, "end": 20}, {"text": "4E-BP1", "start": 40, "end": 46}]}}, "schema": []}
{"input": "Sixteen out of 52 seropositive MS patients (30. 8%) showed intrathecal synthesis of C. pneumoniae-specific IgG but only one of 43 seropositive controls (2. 3%).", "output": {"entities": {"gene": [{"text": "C. pneumoniae-specific IgG", "start": 84, "end": 110}]}}, "schema": []}
{"input": "Far Western blot analysis suggested that the tandem SH2 domains of SHP2 bind to Gab1 in a specific orientation, in which the N-SH2 domain binds to phosphotyrosine (Tyr (P))-627 and the C-SH2 domain binds to Tyr (P)-659.", "output": {"entities": {"gene": [{"text": "SH2 domains", "start": 52, "end": 63}, {"text": "SHP2", "start": 67, "end": 71}, {"text": "Gab1", "start": 80, "end": 84}, {"text": "N-SH2 domain", "start": 125, "end": 137}, {"text": "C-SH2 domain", "start": 185, "end": 197}]}}, "schema": []}
{"input": "Molecular cloning, genomic mapping, and expression of two secretor blood group alpha (1, 2) fucosyltransferase genes differentially regulated in mouse uterine epithelium and gastrointestinal tract.", "output": {"entities": {"gene": [{"text": "secretor blood group alpha (1, 2) fucosyltransferase genes", "start": 58, "end": 116}]}}, "schema": []}
{"input": "The UBA domains of RAD23 and DDI1 are required for these interactions.", "output": {"entities": {"gene": [{"text": "UBA domains", "start": 4, "end": 15}, {"text": "RAD23", "start": 19, "end": 24}, {"text": "DDI1", "start": 29, "end": 33}]}}, "schema": []}
{"input": "It was found that intrathecal administration (i. t.) of D2 receptor agonist LY171555 or D1/D2 receptor agonist apomorphine increased pain threshold and had a potentiating effect on AA.", "output": {"entities": {"gene": [{"text": "D2 receptor", "start": 56, "end": 67}, {"text": "D1/D2 receptor", "start": 88, "end": 102}]}}, "schema": []}
{"input": "The R2 between MFI of fresh and frozen muscle was 0. 94 and 0. 92 for lamb and pork longissimus, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "After all doses of d-amphetamine, responding occurred largely on the saline key under both schedules.", "output": {"entities": {}}, "schema": []}
{"input": "Intravenous L-carnitine treatment increased plasma carnitine concentrations, improved patient-assessed fatigue, and may prevent the decline in peak exercise capacity in hemodialysis patients.", "output": {"entities": {}}, "schema": []}
{"input": "Elevated expression of full-length UhpB or of a soluble hybrid protein, GST-Bc, which is glutathione S-transferase (GST) fused to the cytoplasmic C-terminal portion of UhpB, results in complete blockage of uhpT expression in a uhp (+) strain.", "output": {"entities": {"gene": [{"text": "full-length UhpB", "start": 23, "end": 39}, {"text": "GST", "start": 72, "end": 75}, {"text": "Bc", "start": 76, "end": 78}, {"text": "glutathione S-transferase", "start": 89, "end": 114}, {"text": "GST", "start": 116, "end": 119}, {"text": "UhpB", "start": 168, "end": 172}, {"text": "uhpT", "start": 206, "end": 210}, {"text": "uhp (+)", "start": 227, "end": 234}]}}, "schema": []}
{"input": "Here we show that PKC and p44/p42MAPK signalings are required for the HBx-induced Sp1-mediated IGF-II P4 transcriptional activity since (i) PKC activation by PMA or PKC expression vector increases Sp1 phosphorylation and P4 activity in HBx-transfected HepG2 cells; (ii) PKC inhibition by PKC inhibitor Go6976 reduces Sp1 phosphorylation, P4 activity, and IGF-II mRNA in HBx-transfected HepG2 cells; and (iii) the inhibition of MEK activation by U0126 reduces Sp1 phosphorylation, P4 activity and IGF-II mRNA in HBx-transfected HepG2 cells.", "output": {"entities": {"gene": [{"text": "PKC", "start": 18, "end": 21}, {"text": "p44", "start": 26, "end": 29}, {"text": "p42MAPK", "start": 30, "end": 37}, {"text": "HBx", "start": 70, "end": 73}, {"text": "Sp1", "start": 82, "end": 85}, {"text": "IGF-II P4", "start": 95, "end": 104}, {"text": "PKC", "start": 140, "end": 143}, {"text": "PKC", "start": 165, "end": 168}, {"text": "Sp1", "start": 197, "end": 200}, {"text": "P4", "start": 221, "end": 223}, {"text": "HBx", "start": 236, "end": 239}, {"text": "PKC", "start": 270, "end": 273}, {"text": "PKC", "start": 288, "end": 291}, {"text": "Sp1", "start": 317, "end": 320}, {"text": "P4", "start": 338, "end": 340}, {"text": "IGF-II mRNA", "start": 355, "end": 366}, {"text": "HBx", "start": 370, "end": 373}, {"text": "MEK", "start": 427, "end": 430}, {"text": "Sp1", "start": 459, "end": 462}, {"text": "P4", "start": 480, "end": 482}, {"text": "IGF-II mRNA", "start": 496, "end": 507}, {"text": "HBx", "start": 511, "end": 514}]}}, "schema": []}
{"input": "Through two novel mechanisms, Arf inhibits the oncoprotein Hdm2, a negative regulator of p53.", "output": {"entities": {"gene": [{"text": "Arf", "start": 30, "end": 33}, {"text": "oncoprotein Hdm2", "start": 47, "end": 63}, {"text": "p53", "start": 89, "end": 92}]}}, "schema": []}
{"input": "In the free-swimming rotatory test mice spend most of the time swimming close to the wall of the container attempting to escape from an aversive test situation.", "output": {"entities": {}}, "schema": []}
{"input": "Examination of various promoter deletion mutants indicated that SF-1 acts through the proximal promoter region and upstream promoter sequences.", "output": {"entities": {"gene": [{"text": "SF-1", "start": 64, "end": 68}]}}, "schema": []}
{"input": "Prrp can also associate with the EVH1 domain of Mena, another microfilament-associated protein.", "output": {"entities": {"gene": [{"text": "Prrp", "start": 0, "end": 4}, {"text": "EVH1 domain", "start": 33, "end": 44}, {"text": "Mena", "start": 48, "end": 52}]}}, "schema": []}
{"input": "Srb10 is a physiological regulator of Gcn4 stability because both phosphorylation and turnover of Gcn4 are diminished in srb10 mutants.", "output": {"entities": {"gene": [{"text": "Srb10", "start": 0, "end": 5}, {"text": "Gcn4", "start": 38, "end": 42}, {"text": "Gcn4", "start": 98, "end": 102}, {"text": "srb10 mutants", "start": 121, "end": 134}]}}, "schema": []}
{"input": "A new intron of 476 base pairs was found in the middle of the 5'-untranslated leader sequence and was shown to robustly enhance the promoter activity.", "output": {"entities": {}}, "schema": []}
{"input": "Based on this analysis, we propose that the interactions of Sos with the switch 1 and switch 2 regions of Ras have distinct functional consequences: the interaction with switch 2 mediates the anchoring of Ras to Sos, whereas the interaction with switch 1 leads to disruption of the nucleotide-binding site and GDP dissociation.", "output": {"entities": {"gene": [{"text": "Sos", "start": 60, "end": 63}, {"text": "Ras", "start": 106, "end": 109}, {"text": "Ras", "start": 205, "end": 208}, {"text": "Sos", "start": 212, "end": 215}]}}, "schema": []}
{"input": "A log-linear dose-response was obtained for the average increase in FEV1 up to 6 h (AUC0-6 h) and peak FEV1 across the dose range administered by Respimat.", "output": {"entities": {}}, "schema": []}
{"input": "Bandshift experiments demonstrate that BmHR3A binds specifically to RORE (Retinoic acid-related Orphan receptor Response Element)-like sequences in the promoters of both genes, thus suggesting a direct role for BmHR3A in regulating the expression of BmGATAbeta and ESP genes during vitellogenesis.", "output": {"entities": {"gene": [{"text": "BmHR3A", "start": 39, "end": 45}, {"text": "RORE", "start": 68, "end": 72}, {"text": "Retinoic acid-related Orphan receptor Response Element", "start": 74, "end": 128}, {"text": "BmHR3A", "start": 211, "end": 217}, {"text": "BmGATAbeta", "start": 250, "end": 260}, {"text": "ESP genes", "start": 265, "end": 274}]}}, "schema": []}
{"input": "This was most pronounced during the initial phase of Erk activation.", "output": {"entities": {"gene": [{"text": "Erk", "start": 53, "end": 56}]}}, "schema": []}
{"input": "The iterative method proposed by Bengtsson [Appl.", "output": {"entities": {}}, "schema": []}
{"input": "The COD and color removals were both more than 90% when FeCl3 was used as the coagulation (dosages of two-step coagulation were 0. 031 and 0. 012 mol/L respectively) after a ferrous hydrogen peroxide oxidation pretreatment at a H2O2 dosage of 0. 06 mol/L.", "output": {"entities": {}}, "schema": []}
{"input": "Although there was a high correlation between sap flux densities registered by the old and new sensors, significant differences in sap flux densities between the duplicated sensors were detected.", "output": {"entities": {}}, "schema": []}
{"input": "Three of the proteins involved in checkpoint signaling, Rad1, Hus1, and Rad9, have been shown to interact by immunoprecipitation and yeast two-hybrid studies.", "output": {"entities": {"gene": [{"text": "Rad1", "start": 56, "end": 60}, {"text": "Hus1", "start": 62, "end": 66}, {"text": "Rad9", "start": 72, "end": 76}]}}, "schema": []}
{"input": "Based on the hypothesis that evolutionarily conserved regions are functionally important and likely to interact with coactivators, we compared the amino acid sequence of C/EBPalpha from different species (frog to human) and identified four highly conserved regions (CR1-CR4) within the transactivation domain.", "output": {"entities": {"gene": [{"text": "C/EBPalpha", "start": 170, "end": 180}]}}, "schema": []}
{"input": "Tolerance to ADAL-2 was similar to that of Vicryl suture and tolerance to ADAL-2 was superior to that to Tisuacryl.", "output": {"entities": {}}, "schema": []}
{"input": "Of the patients in each regimen who reached study end points, 17 of 29 (59%) were in regimen A, 11 of 20 (55%) were in regimen B, and 28 of 43 (65%) were in regimen C met the treatment success criterion.", "output": {"entities": {}}, "schema": []}
{"input": "SAMPLE POPULATION: MCB from 7 racing Greyhounds euthanatized for reasons unrelated to MCB abnormalities.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS AND CLINICAL RELEVANCE: Increased cortical thickness and geometric properties of left MCB-IV and-V of Greyhounds, together with altered turnover and orientation of osteons in the dorsal quadrants of left MCB, are site-specific adaptive responses associated with asymmetric cyclic loading as a result of racing on circular tracks.", "output": {"entities": {}}, "schema": []}
{"input": "METHODS AND RESULTS: Palmaz-Schatz stents were dip-coated with paclitaxel (0, 0. 2, 15, or 187 microgram/stent) by immersion in ethanolic paclitaxel and evaporation of the solvent.", "output": {"entities": {}}, "schema": []}
{"input": "Percentages of recovery for overload and dilution tests were between 87 and 120%.", "output": {"entities": {}}, "schema": []}
{"input": "One of the conserved RNA subdomains, designated P3, has previously been shown to be required for nucleolar localization.", "output": {"entities": {"gene": [{"text": "P3", "start": 48, "end": 50}]}}, "schema": []}
{"input": "In Cd-spiked OECD soil, internal Cd levels were linearly related to external Cd concentrations, whereas the springtails maintained fixed internal levels of Cu and Zn regardless of spiked concentrations.", "output": {"entities": {}}, "schema": []}
{"input": "Nutritional status in adults on an alternative or traditional diet] BACKGROUND: Plant food lacks vitamin B12, vitamin D and higher n-3 polyunsaturated fatty acids.", "output": {"entities": {}}, "schema": []}
{"input": "It is useful as an adjunct to mammography in those patients with radiographically dense breasts for the characterization of palpable masses.", "output": {"entities": {}}, "schema": []}
{"input": "Measurements were obtained: (i) just after the traumatic exposure (D0); (ii) 3 days after this first measurement (D3); and (iii) 30 days after (D30).", "output": {"entities": {}}, "schema": []}
{"input": "Changes of the DB sequence without affecting the postulated stem structure led to drastic losses of translation efficiency.", "output": {"entities": {}}, "schema": []}
{"input": "It has been suggested that members of this protein family exhibit both prolyl isomerase and chaperone activity.", "output": {"entities": {"gene": [{"text": "prolyl isomerase", "start": 71, "end": 87}]}}, "schema": []}
{"input": "Inhibition of the Raf-1 target ERK kinase (MEK) either attenuated or abolished Rp-cAMPS-and PKI-induced ERK activation, caldesmon phosphorylation, and stress fiber formation.", "output": {"entities": {"gene": [{"text": "Raf-1 target ERK kinase", "start": 18, "end": 41}, {"text": "MEK", "start": 43, "end": 46}, {"text": "PKI", "start": 92, "end": 95}, {"text": "ERK", "start": 104, "end": 107}, {"text": "caldesmon", "start": 120, "end": 129}]}}, "schema": []}
{"input": "PACAP mRNA was widely expressed in most human tissues; in transfected cells, PACAP was diffusely expressed in the cytoplasm.", "output": {"entities": {"gene": [{"text": "PACAP mRNA", "start": 0, "end": 10}, {"text": "PACAP", "start": 77, "end": 82}]}}, "schema": []}
{"input": "The radial forearm flap is used most commonly, however the lateral arm flap may be the flap of choice in certain situations.", "output": {"entities": {}}, "schema": []}
{"input": "By comparison, in nontumorigenic Ad5 cells, class I expression is high due to negligible binding of COUP-TF and strong binding of NF-kappaB.", "output": {"entities": {"gene": [{"text": "COUP-TF", "start": 100, "end": 107}, {"text": "NF-kappaB", "start": 130, "end": 139}]}}, "schema": []}
{"input": "As an application of reverse genetics, we introduced one nucleotide change (UCU to ACU) to immediate downstream of the RNA-editing site of the V gene in the full-length hPIV2 cDNA and were able to obtain infectious viruses [rPIV2V (-)] from the cDNA.", "output": {"entities": {"gene": [{"text": "V gene", "start": 143, "end": 149}]}}, "schema": []}
{"input": "The frameshift initiated by ADEx2 is believed to alter the regular coding sequence, acting as a loss-of-function ASIP mutation.", "output": {"entities": {"gene": [{"text": "ASIP mutation", "start": 113, "end": 126}]}}, "schema": []}
{"input": "In regards to the latter activity, it has been shown that S3 contains vigorous N-glycosylase activity for the removal of 8-oxoguanine residues in DNA that leaves baseless sites in their places.", "output": {"entities": {"gene": [{"text": "S3", "start": 58, "end": 60}, {"text": "N-glycosylase", "start": 79, "end": 92}]}}, "schema": []}
{"input": "Here we report the isolation and characterization of the forkhead homologue in rhabdomyosarcoma (FKHR), a recently described member of the hepatocyte nuclear factor 3/forkhead homeotic gene family, as a nuclear hormone receptor (NR) intermediary protein.", "output": {"entities": {"gene": [{"text": "forkhead homologue in rhabdomyosarcoma", "start": 57, "end": 95}, {"text": "FKHR", "start": 97, "end": 101}, {"text": "hepatocyte nuclear factor 3", "start": 139, "end": 166}, {"text": "forkhead homeotic gene family", "start": 167, "end": 196}, {"text": "nuclear hormone receptor", "start": 203, "end": 227}, {"text": "NR", "start": 229, "end": 231}]}}, "schema": []}
{"input": "The improved CSF outflow conductance may increase the intracranial compliance and thereby dampen a pathological ICP waveform.", "output": {"entities": {}}, "schema": []}
{"input": "A new species of Euspondylus is described based on a female (taken within a bromeliad) from Cerro El Humo, Sucre, northeastern Venezuela.", "output": {"entities": {}}, "schema": []}
{"input": "The cyclins bind to and activate the CDK, which leads to phosphorylation (and then inhibition) of the tumor suppressor protein, pRb. pRb controls commitment to progress from the G1 to S phase, at least in part by repressing the activity of the E2F transcription factors known to promote cell proliferation.", "output": {"entities": {"gene": [{"text": "cyclins", "start": 4, "end": 11}, {"text": "CDK", "start": 37, "end": 40}, {"text": "pRb", "start": 128, "end": 131}, {"text": "pRb", "start": 133, "end": 136}, {"text": "E2F transcription factors", "start": 244, "end": 269}]}}, "schema": []}
{"input": "Additional education and research is needed to provide further direction for intervention and incorporation into practice.", "output": {"entities": {}}, "schema": []}
{"input": "Proliferative vasculopathy and cutaneous hemorrhages in porcine neonates infected with the porcine reproductive and respiratory syndrome virus.", "output": {"entities": {}}, "schema": []}
{"input": "The difference of hardness over time of composite specimens was measured using Knoop hardness measurements taken at the top and bottom surfaces of resin specimens made in a Teflon mold the same dimensions as the cavity prepared in dentin.", "output": {"entities": {}}, "schema": []}
{"input": "An 18-kb genomic clone including sequences encoding for the two GHS-R variants was isolated.", "output": {"entities": {"gene": [{"text": "GHS-R variants", "start": 64, "end": 78}]}}, "schema": []}
{"input": "Saccharomyces cerevisiae activates a regulatory network called \" general control \" that provides the cell with sufficient amounts of protein precursors during amino acid starvation.", "output": {"entities": {}}, "schema": []}
{"input": "In Ka13 cells, CoCl (2) stimulated expression of a luciferase reporter gene under the control of a 15-kilobase pair mouse ho-1 promoter (pHO15luc).", "output": {"entities": {"gene": [{"text": "luciferase reporter gene", "start": 51, "end": 75}, {"text": "15-kilobase pair mouse ho-1 promoter", "start": 99, "end": 135}, {"text": "pHO15luc", "start": 137, "end": 145}]}}, "schema": []}
{"input": "Mutation analyses identified the cobalt-responsive sequences as the stress-response elements (StREs).", "output": {"entities": {}}, "schema": []}
{"input": "Members of the AP-1 superfamily of basic-leucine zipper factors bind to the StRE.", "output": {"entities": {"gene": [{"text": "AP-1 superfamily of basic-leucine zipper factors", "start": 15, "end": 63}]}}, "schema": []}
{"input": "Descriptions of this locus would allow comparison with functionally relevant molecular genetic features of other species' homologous loci including the single-copy equid LH/CGbeta gene and the primate LHbeta-CGbeta gene cluster locus.", "output": {"entities": {"gene": [{"text": "LH", "start": 170, "end": 172}, {"text": "CGbeta", "start": 173, "end": 179}, {"text": "LHbeta", "start": 201, "end": 207}, {"text": "CGbeta", "start": 208, "end": 214}]}}, "schema": []}
{"input": "Like the consensus mammalian LHbeta gene, the 5'-flanking region of the gpLH/CGbeta gene contains a single TATA sequence 37 bp upstream of the translation start codon.", "output": {"entities": {"gene": [{"text": "consensus mammalian LHbeta gene", "start": 9, "end": 40}, {"text": "gpLH", "start": 72, "end": 76}, {"text": "CGbeta", "start": 77, "end": 83}]}}, "schema": []}
{"input": "This shows that in situations of separated breaks, NHEJ deficiency leads to genomic rearrangements, in agreement with chromosomal studies.", "output": {"entities": {}}, "schema": []}
{"input": "Foxp1 and Foxp2 are expressed at high levels in the lung as early as E12. 5 of mouse development with Foxp2 expression restricted to the airway epithelium.", "output": {"entities": {"gene": [{"text": "Foxp1", "start": 0, "end": 5}, {"text": "Foxp2", "start": 10, "end": 15}, {"text": "Foxp2", "start": 102, "end": 107}]}}, "schema": []}
{"input": "Immunological and biochemical characterization of streptococcal pyrogenic exotoxins I and J (SPE-I and SPE-J) from Streptococcus pyogenes.", "output": {"entities": {"gene": [{"text": "streptococcal pyrogenic exotoxins I and J", "start": 50, "end": 91}, {"text": "SPE-I", "start": 93, "end": 98}, {"text": "SPE-J", "start": 103, "end": 108}]}}, "schema": []}
{"input": "Several dozen HIF-1 targets are known, including the gene encoding vascular endothelial growth factor (VEGF).", "output": {"entities": {"gene": [{"text": "HIF-1 targets", "start": 14, "end": 27}, {"text": "vascular endothelial growth factor", "start": 67, "end": 101}, {"text": "VEGF", "start": 103, "end": 107}]}}, "schema": []}
{"input": "We previously reported that Tax induced cell cycle progression from G0/G1 phase to S and G2/M phases in human T-cell line Kit 225 cells.", "output": {"entities": {"gene": [{"text": "Tax", "start": 28, "end": 31}]}}, "schema": []}
{"input": "Most yeast peroxisomal matrix proteins contain a type 1C-terminal peroxisomal targeting signal (PTS1) consisting of the tripeptide SKL or a conservative variant thereof.", "output": {"entities": {"gene": [{"text": "yeast peroxisomal matrix proteins", "start": 5, "end": 38}]}}, "schema": []}
{"input": "Here, the PEX5-TPR domains from human, tobacco, and nematode were inserted into a TPR-less yeast Pex5p construct to generate Pex5p chimaeras.", "output": {"entities": {"gene": [{"text": "PEX5", "start": 10, "end": 14}, {"text": "Pex5p", "start": 97, "end": 102}, {"text": "Pex5p", "start": 125, "end": 130}]}}, "schema": []}
{"input": "HIV-1 and hepatitis B virus infections in adolescents lodged in security institutes of Buenos Aires.", "output": {"entities": {}}, "schema": []}
{"input": "Immunofixation experiments of C4A and C4B demonstrate > 41 allotypes in the two classes of proteins.", "output": {"entities": {"gene": [{"text": "C4A", "start": 30, "end": 33}, {"text": "C4B", "start": 38, "end": 41}]}}, "schema": []}
{"input": "However, C4B proteins encoded by monomodular short genes may have relatively higher concentrations than those from long C4A genes.", "output": {"entities": {"gene": [{"text": "C4B proteins", "start": 9, "end": 21}, {"text": "long C4A genes", "start": 115, "end": 129}]}}, "schema": []}
{"input": "In the course of screening for transcription factors which interact with the human myeloperoxidase (MPO) promoter we, for the first time, identified and cloned the cDNA and genomic DNA for human HBP1 (HMG-Box containing protein 1), a member of the high mobility group of non-histone chromosomal proteins.", "output": {"entities": {"gene": [{"text": "human myeloperoxidase", "start": 77, "end": 98}, {"text": "MPO", "start": 100, "end": 103}, {"text": "human HBP1", "start": 189, "end": 199}, {"text": "HMG-Box containing protein 1", "start": 201, "end": 229}, {"text": "high mobility group of non-histone chromosomal proteins", "start": 248, "end": 303}]}}, "schema": []}
{"input": "The human protein sequence exhibits a putative DNA-binding domain similar to that seen in rat HBP1 and shows homology with the activation and repressor domains previously demonstrated in the rat protein.", "output": {"entities": {"gene": [{"text": "rat HBP1", "start": 90, "end": 98}]}}, "schema": []}
{"input": "Promoter transcriptional activity was determined for a wide 5' portion of the human annexin A5 gene, from bp-1275 to + 79 relative to the most 5' of several discrete transcription start points.", "output": {"entities": {"gene": [{"text": "annexin A5 gene", "start": 84, "end": 99}]}}, "schema": []}
{"input": "In contrast the human and mouse BCNT proteins contain one repeat unit and lack the RTE-1-derived portion.", "output": {"entities": {"gene": [{"text": "mouse BCNT proteins", "start": 26, "end": 45}, {"text": "RTE-1", "start": 83, "end": 88}]}}, "schema": []}
{"input": "Molecular identification of smg-4, required for mRNA surveillance in C. elegans.", "output": {"entities": {"gene": [{"text": "smg-4", "start": 28, "end": 33}]}}, "schema": []}
{"input": "Two remotely situated exons within the complement C3 gene locus encode an alternate 5' end and proximal ORF under the control of a bidirectional promoter.", "output": {"entities": {"gene": [{"text": "complement C3", "start": 39, "end": 52}]}}, "schema": []}
{"input": "CONCLUSIONS: Adding MMF, a potent topical corticosteroid, to an emollient cream is statistically significantly more effective than emollient cream alone in reducing acute radiation dermatitis.", "output": {"entities": {}}, "schema": []}
{"input": "Recent advances have shown that volatile sulfur is a result of ecological interactions and transformation processes through planktonic food webs.", "output": {"entities": {}}, "schema": []}
{"input": "The first hypothesis was supported in the sense that stimulus differences might affect behaviour even without their successful attentive processing in normal participants.", "output": {"entities": {}}, "schema": []}
{"input": "There was an increase in protein binding onto this element only after peptide treatment.", "output": {"entities": {}}, "schema": []}
{"input": "CSR is directed to specific heavy chain isotypes by cytokines and B cell activators that induce transcription from the unrearranged, or germline (GL), C (H) region genes.", "output": {"entities": {"gene": [{"text": "C (H) region genes", "start": 151, "end": 169}]}}, "schema": []}
{"input": "In this manuscript we demonstrate that two tandem Ets sites in the mouse GL alpha promoter bind the transcription factors Elf-1 and PU. 1, and that the 3' site is essential for expression of a luciferase reporter gene driven by the GL alpha promoter.", "output": {"entities": {"gene": [{"text": "tandem Ets sites", "start": 43, "end": 59}, {"text": "mouse GL alpha promoter", "start": 67, "end": 90}, {"text": "transcription factors Elf-1", "start": 100, "end": 127}, {"text": "PU. 1", "start": 132, "end": 137}, {"text": "luciferase reporter gene", "start": 193, "end": 217}, {"text": "GL alpha promoter", "start": 232, "end": 249}]}}, "schema": []}
{"input": "Cell.", "output": {"entities": {}}, "schema": []}
{"input": "The mean serum creatinine level did not change during the first 6 months after withdrawal of MMF.", "output": {"entities": {}}, "schema": []}
{"input": "The proportion of the biopsies found to be seropositive for HBs antigen was 27. 9%, and these showed either MGN or MPGN pattern.", "output": {"entities": {"gene": [{"text": "HBs antigen", "start": 60, "end": 71}]}}, "schema": []}
{"input": "They correspond to nucleotides equivalent to base-pair C1-G72 and discriminator base A73 in the amino acid-acceptor branch of the molecule.", "output": {"entities": {}}, "schema": []}
{"input": "This domain without the canonical anticodon loop or the tyrosine anticodon acts as an anchor for TyrRS interaction leading to a better efficiency of tyrosylation.", "output": {"entities": {"gene": [{"text": "TyrRS", "start": 97, "end": 102}]}}, "schema": []}
{"input": "During most of the cell cycle, separase is kept inactive by binding to an inhibitory protein called securin.", "output": {"entities": {"gene": [{"text": "separase", "start": 31, "end": 39}, {"text": "securin", "start": 100, "end": 107}]}}, "schema": []}
{"input": "Mechanical ventilation in control lungs produced a 47% decrease in chord compliance, an increase in lung lavage levels of tumor necrosis factor (TNF)-alpha (722 +/-306 pg/ml), interleukin (IL)-1beta (902 +/-322 pg/ml), and macrophage inflammatory protein-2 (MIP-2) (363 +/-104 pg/ml) as compared with low levels of cytokines detected in preventilation data, and no change in percentage of surfactant large aggregates (LA).", "output": {"entities": {"gene": [{"text": "tumor necrosis factor (TNF)-alpha", "start": 122, "end": 155}, {"text": "interleukin (IL)-1beta", "start": 176, "end": 198}, {"text": "macrophage inflammatory protein-2", "start": 223, "end": 256}, {"text": "MIP-2", "start": 258, "end": 263}]}}, "schema": []}
{"input": "Maternal p, p' DDE and beta-HCH levels were also associated with newborn levels, but levels of PCBs were not.", "output": {"entities": {}}, "schema": []}
{"input": "Multiple regression analysis performed between these long-term abiotic factors and nymphal abundance in positive sites showed high relationship (R2 coefficients) for every habitat category and explained > 50% of the variation in tick abundance.", "output": {"entities": {}}, "schema": []}
{"input": "In summary, we conclude that the adenoviral oncoprotein E1A activates transcription from the endogenous AP-2alpha gene, an effect that involves transcriptional derepression of the AP-2alpha promoter by interaction of E1A with the AP-2rep corepressor CtBP1.", "output": {"entities": {"gene": [{"text": "E1A", "start": 56, "end": 59}, {"text": "AP-2alpha gene", "start": 104, "end": 118}, {"text": "AP-2alpha promoter", "start": 180, "end": 198}, {"text": "E1A", "start": 217, "end": 220}, {"text": "AP-2rep", "start": 230, "end": 237}, {"text": "CtBP1", "start": 250, "end": 255}]}}, "schema": []}
{"input": "Additional factors such as advanced age, concomitant use of corticosteroids or anticoagulants, prior ulcer complications and co-morbid diseases may further increase the risk of bleeding.", "output": {"entities": {}}, "schema": []}
{"input": "The core promoter of human thioredoxin reductase 1: cloning, transcriptional activity, and Oct-1, Sp1, and Sp3 binding reveal a housekeeping-type promoter for the AU-rich element-regulated gene.", "output": {"entities": {"gene": [{"text": "human thioredoxin reductase 1", "start": 21, "end": 50}, {"text": "Oct-1", "start": 91, "end": 96}, {"text": "Sp1", "start": 98, "end": 101}, {"text": "Sp3", "start": 107, "end": 110}]}}, "schema": []}
{"input": "Here we show that phosphorylation-induced loss of the protein kinase activity of DNA-PK is restored by the addition of the purified catalytic subunit of either protein phosphatase 1 or protein phosphatase 2A (PP2A) and that this reactivation is blocked by the potent protein phosphatase inhibitor, microcystin.", "output": {"entities": {"gene": [{"text": "DNA-PK", "start": 81, "end": 87}, {"text": "protein phosphatase 1", "start": 160, "end": 181}, {"text": "protein phosphatase 2A", "start": 185, "end": 207}, {"text": "PP2A", "start": 209, "end": 213}]}}, "schema": []}
{"input": "The first exon (exon 1A) that corresponded to the 5'-untranslated region of the GHR 1A mRNA was 15, 250 bp upstream from exon 2 in the GHR gene.", "output": {"entities": {"gene": [{"text": "GHR 1A mRNA", "start": 80, "end": 91}, {"text": "GHR gene", "start": 135, "end": 143}]}}, "schema": []}
{"input": "FLP and Cre recombinase function in Xenopus embryos.", "output": {"entities": {"gene": [{"text": "FLP", "start": 0, "end": 3}, {"text": "Cre recombinase", "start": 8, "end": 23}]}}, "schema": []}
{"input": "A method of three-station three-dimensional magnetic resonance (MR) angiography of the lower extremities with segmented volume acquisition is presented.", "output": {"entities": {}}, "schema": []}
{"input": "A single nucleotide polymorphism (SNP) in exon 2, which is tightly liked to another SNP (GTG83/ATG83), creates an additional alternative in-frame AUG in B-type MTH1 mRNAs yielding the fourth MTH1 polypeptide, p26 that possesses an additional mitochondrial targeting signal.", "output": {"entities": {"gene": [{"text": "B-type MTH1 mRNAs", "start": 153, "end": 170}, {"text": "MTH1 polypeptide", "start": 191, "end": 207}, {"text": "p26", "start": 209, "end": 212}]}}, "schema": []}
{"input": "Our previous studies have shown that SHP-1, a SH2 domain-containing protein-tyrosine phosphatase, is expressed not only in cells of hematopoietic lineages, but also in many non-hematopoietic cells under the control of an alternative tissue-specific promoter, P1.", "output": {"entities": {"gene": [{"text": "SHP-1", "start": 37, "end": 42}, {"text": "SH2 domain-containing protein-tyrosine phosphatase", "start": 46, "end": 96}]}}, "schema": []}
{"input": "Unexpectedly, Arg1-expressing COS1 cells showed no significant proteinase activity to various synthesized substrates under neutral or acidic conditions in this study.", "output": {"entities": {"gene": [{"text": "Arg1", "start": 14, "end": 18}]}}, "schema": []}
{"input": "ORF1 (1029 bp; EMBL databank, Accession No.", "output": {"entities": {}}, "schema": []}
{"input": "In the meantime, one has succeeded to establish the deammonification processes in a continuous flow moving-bed pilot plant.", "output": {"entities": {}}, "schema": []}
{"input": "The purpose of this study was to evaluate simplified methods for estimation of Technetium Tc 99m (99mTc)-pentetate and orthoiodohippurate I 131 (131I-OIH) plasma clearance in dogs and cats with 1 and 2 blood samples.", "output": {"entities": {}}, "schema": []}
{"input": "Interventions aimed at these specific mediators and processes may be successful in reducing the very significant human and economic costs of vascular access dysfunction.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, stonin 2 binds to the C2B domains of synaptotagmins I and II.", "output": {"entities": {"gene": [{"text": "stonin 2", "start": 13, "end": 21}, {"text": "synaptotagmins I and II", "start": 50, "end": 73}]}}, "schema": []}
{"input": "This partial transection could permit vasopressin to be secreted in response to a larger rise in plasma sodium concentration.", "output": {"entities": {"gene": [{"text": "vasopressin", "start": 38, "end": 49}]}}, "schema": []}
{"input": "In conclusion, USPIO-enhanced MRI data were capable to characterize tumor microvessel properties in this breast cancer model: microvascular permeability (determined using USPIO) correlated significantly with tumor grade.", "output": {"entities": {}}, "schema": []}
{"input": "However, the N63S mutation in the wild-type VP5 background increased the interaction, as judged by the beta-galactosidase activity, by a factor of 9 relative to when the PR7 mutation was present.", "output": {"entities": {"gene": [{"text": "wild-type VP5", "start": 34, "end": 47}, {"text": "beta-galactosidase", "start": 103, "end": 121}]}}, "schema": []}
{"input": "An integrated RTC algorithm for the urban wastewater system is formulated, the parameters of which are optimized using various global optimization routines.", "output": {"entities": {}}, "schema": []}
{"input": "SKP1-SnRK protein kinase interactions mediate proteasomal binding of a plant SCF ubiquitin ligase.", "output": {"entities": {"gene": [{"text": "SKP1", "start": 0, "end": 4}, {"text": "SnRK", "start": 5, "end": 9}, {"text": "SCF ubiquitin ligase", "start": 77, "end": 97}]}}, "schema": []}
{"input": "PATIENTS AND METHODS: Between June 1991 and December 1996, we administered the nucleoside analog 2-chlorodeoxyadenosine (2-CDA) to 73 children with primary AML and 20 children with secondary AML or myelodysplastic syndrome (MDS).", "output": {"entities": {}}, "schema": []}
{"input": "The severity of pathologic changes increased with the magnitude of percussion.", "output": {"entities": {}}, "schema": []}
{"input": "Experimental study of ta chengchi tang decoction for relieving lung injury during acute necrotizing pancreatitis] The objectives of the study were to investigate the changes of leukocyte adhesiveness and tumor necrosis factor (TNF) in the early stage of acute necrotizing pancreatitis (ANP), to go further into the relation of those changes to lung injury of ANP, and to evaluate the prohibitive effect of ta chengchi tang Decoction on leukocyte adhesion and TNF secretion.", "output": {"entities": {"gene": [{"text": "tumor necrosis factor", "start": 204, "end": 225}, {"text": "TNF", "start": 227, "end": 230}, {"text": "TNF", "start": 459, "end": 462}]}}, "schema": []}
{"input": "A variety of receptor-mediated signaling pathways are controlled by both positive and negative extracellular regulators.", "output": {"entities": {}}, "schema": []}
{"input": "TT cells, a human MTC cell line expressing MEN 2A type RET, display transcriptionally active RelA (p65) in the nucleus.", "output": {"entities": {"gene": [{"text": "MEN 2A type RET", "start": 43, "end": 58}, {"text": "RelA (p65)", "start": 93, "end": 103}]}}, "schema": []}
{"input": "Inhibition of constitutive NF-kappaB activity results in cell death of TT cells and blocks focus formation induced by oncogenic forms of RET in NIH 3T3 cells.", "output": {"entities": {"gene": [{"text": "NF-kappaB", "start": 27, "end": 36}, {"text": "RET", "start": 137, "end": 140}]}}, "schema": []}
{"input": "Reciprocally, HMGI-C expression also coordinately enhances PIAS3-mediated repression of STAT3-dependent transactivation.", "output": {"entities": {"gene": [{"text": "HMGI-C", "start": 14, "end": 20}, {"text": "PIAS3", "start": 59, "end": 64}, {"text": "STAT3", "start": 88, "end": 93}]}}, "schema": []}
{"input": "A central finding is the identification of a GC-rich sequence in the-99/-91 Cp region that is essential for oriPI-EBNA1-independent as well as oriPI-EBNA1-dependent activity of the promoter.", "output": {"entities": {"gene": [{"text": "Cp", "start": 76, "end": 78}, {"text": "EBNA1", "start": 114, "end": 119}, {"text": "EBNA1", "start": 149, "end": 154}]}}, "schema": []}
{"input": "Additional deletion mutations revealed a new, 67-amino-acid functional domain within the proline-rich region of SLP-76, which we have termed the P-1 domain.", "output": {"entities": {"gene": [{"text": "SLP-76", "start": 112, "end": 118}]}}, "schema": []}
{"input": "Finally, profiling of a gcn4Delta mutant uncovered an alternative induction pathway operating at many Gcn4p target genes in histidine-starved cells.", "output": {"entities": {"gene": [{"text": "gcn4Delta mutant", "start": 24, "end": 40}, {"text": "Gcn4p target genes", "start": 102, "end": 120}]}}, "schema": []}
{"input": "Evidence from a Northern hybridization indicated that jadM expression is correlated with jadomycin B synthesis.", "output": {"entities": {"gene": [{"text": "jadM", "start": 54, "end": 58}, {"text": "jadomycin B", "start": 89, "end": 100}]}}, "schema": []}
{"input": "Right LHR (R-LHR) provided the best interobserver and intraobserver reproducibility.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS: The methodology of LHR measurement significantly influences the clinical contribution of Tl-201 lung uptake evaluation.", "output": {"entities": {}}, "schema": []}
{"input": "Mutation of the NF-kappaB site in the Mdr1b promoter prevents its induction by TNF-alpha.", "output": {"entities": {"gene": [{"text": "NF-kappaB site", "start": 16, "end": 30}, {"text": "Mdr1b promoter", "start": 38, "end": 52}, {"text": "TNF-alpha", "start": 79, "end": 88}]}}, "schema": []}
{"input": "To determine the genomic complexity of the deleted region shared among tumors, we assembled a physical map of the I Mbp SRO consisting predominantly of bacteriophage P1-derived artificial chromosome (PAC) clones.", "output": {"entities": {}}, "schema": []}
{"input": "Online teaching: design and techniques.", "output": {"entities": {}}, "schema": []}
{"input": "Data were obtained from 2 undergraduate student samples, a self-report group (n = 132) who provided NEO-PI-R self-ratings on 2 occasions separated by a 7-to 14-day interval and an informant group (n = 109) who provided ratings of well-known friends or relatives on 2 occasions separated by a 6 month interval.", "output": {"entities": {}}, "schema": []}
{"input": "Northern blot analysis of RNAs from a number of mouse tissues reveals that Atp6i is expressed predominantly in osteoclasts, and this predominant expression was confirmed by reverse-transcription polymerase chain reaction (RT-PCR) assay and immunohistochemical analysis.", "output": {"entities": {"gene": [{"text": "Atp6i", "start": 75, "end": 80}]}}, "schema": []}
{"input": "Indeed, mutation of two of these motifs, known to be important to regulation of sid1, altered the differential regulation of sid2 by iron.", "output": {"entities": {"gene": [{"text": "sid1", "start": 80, "end": 84}, {"text": "sid2", "start": 125, "end": 129}]}}, "schema": []}
{"input": "The described results show that DTD is fast, simple, and easy to automate; requires only a small amount of sample (approximately 50 mg); and affords quantitative information about the main groups of compounds present in cheeses.", "output": {"entities": {}}, "schema": []}
{"input": "Guidelines for performing a routine spiral assay are presented, and alternative test methods intended to overcome a variety of technical difficulties (such as restricted sample availability, sample viscosity or volatility, etc.) are recommended.", "output": {"entities": {}}, "schema": []}
{"input": "In conclusion, obesity, alcohol intake, and multimetabolic disorders were determined to be independent predictors for the development of hyperuricemia.", "output": {"entities": {}}, "schema": []}
{"input": "Autoregulation enables different pathways to control CCAAT/enhancer binding protein beta (C/EBP beta) transcription.", "output": {"entities": {"gene": [{"text": "CCAAT/enhancer binding protein beta", "start": 53, "end": 88}, {"text": "C/EBP beta", "start": 90, "end": 100}]}}, "schema": []}
{"input": "As a reflection of uncertainties in the estimates for individual sources, the 90th percentiles of PCDD/F releases for 1999 ranged up to 4. 1 g I-TEQ/y.", "output": {"entities": {}}, "schema": []}
{"input": "Gabapentin for opiod-related myoclonus in cancer patients.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS: Our meta-analysis of randomized controlled trials of HRT noted a statistically significant reduction in nonvertebral fractures.", "output": {"entities": {}}, "schema": []}
{"input": "Newcastle disease antibody titre is dependent on serum calcium concentration.", "output": {"entities": {"gene": [{"text": "Newcastle disease antibody", "start": 0, "end": 26}]}}, "schema": []}
{"input": "A total of 25 patients with malignant brain tumours were investigated.", "output": {"entities": {}}, "schema": []}
{"input": "Net lift and combined drag from all 8 bearings of the 4-bladed impeller are compared with predictions based on 2-D theory.", "output": {"entities": {}}, "schema": []}
{"input": "Our results indicate that Gab1 is involved in the control of egr-1 expression regulated by insulin.", "output": {"entities": {"gene": [{"text": "Gab1", "start": 26, "end": 30}, {"text": "egr-1", "start": 61, "end": 66}, {"text": "insulin", "start": 91, "end": 98}]}}, "schema": []}
{"input": "The co-existence of TE domains within modular PKSs along with physically separated, monofunctional TEs (TE IIs) has been reported for a number of modular polyketide and non-ribosomal peptide synthases (NRPS).", "output": {"entities": {"gene": [{"text": "TE domains", "start": 20, "end": 30}, {"text": "PKSs", "start": 46, "end": 50}, {"text": "TEs", "start": 99, "end": 102}, {"text": "TE IIs", "start": 104, "end": 110}, {"text": "non-ribosomal peptide synthases", "start": 169, "end": 200}, {"text": "NRPS", "start": 202, "end": 206}]}}, "schema": []}
{"input": "To gain an understanding of the mGSTM2 regulation, we have also cloned and analyzed its promoter region.", "output": {"entities": {"gene": [{"text": "mGSTM2", "start": 32, "end": 38}]}}, "schema": []}
{"input": "10. 0 +/-2. 0 pmol/24 h, P < 0. 01) and remained elevated.", "output": {"entities": {}}, "schema": []}
{"input": "SELECTION CRITERIA: All randomised controlled trials comparing IUSs with other forms of reversible contraceptives and reporting on pre-determined outcomes in women of reproductive years.", "output": {"entities": {}}, "schema": []}
{"input": "OBJECTIVES: The objective of this review was to compare the effectiveness, safety and acceptability of the diaphragm with and without spermicide.", "output": {"entities": {}}, "schema": []}
{"input": "To test the hypothesis that these elements are required for promoter activity, we compared the reporter expression activity of segments containing mutations of these elements with activity of the parent Hlx promoter sequence.", "output": {"entities": {"gene": [{"text": "parent Hlx promoter sequence", "start": 196, "end": 224}]}}, "schema": []}
{"input": "In all of these cases, expression of the implicated genes was absent.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS: Ketamine-induced dissociative anesthesia produces persistently elevated BIS index which is different from thiamylal and those reported with other conventional anesthetic agents.", "output": {"entities": {}}, "schema": []}
{"input": "Our results are reassuring and we therefore advise that in patients undergoing free jejunum flap reconstruction of the hypopharyngo-esophageal tract voice restoration should be attempted by placing a voice prosthesis through a secondary tracheo-esophageal puncture and providing intensive speech training.", "output": {"entities": {}}, "schema": []}
{"input": "Hypercalcemia associated with elevated serum PTH concentration indicating primary hyperparathyroidism was found in 7 BC patients (7%) and in none of healthy women or patients with thyroid cancer.", "output": {"entities": {"gene": [{"text": "serum PTH", "start": 39, "end": 48}]}}, "schema": []}
{"input": "Positive and significant correlations were found between the weeks of pregnancy and Se levels in kidney (r = 0. 433, P = 0. 023) and heart (r = 0. 313, P = 0. 030).", "output": {"entities": {}}, "schema": []}
{"input": "This study suggests that PSP is more common than previously considered, is commonly misdiagnosed and that the majority of cases are not initially referred to neurologists.", "output": {"entities": {}}, "schema": []}
{"input": "In Saccharomyces cerevisiae, entry into mitosis requires activation of the cyclin-dependent kinase Cdc28 in its cyclin B (Clb)-associated form.", "output": {"entities": {"gene": [{"text": "cyclin-dependent kinase Cdc28", "start": 75, "end": 104}, {"text": "cyclin B", "start": 112, "end": 120}, {"text": "Clb", "start": 122, "end": 125}]}}, "schema": []}
{"input": "We investigated the production of hyaluronan (HA) and its effect on cell motility in cells expressing the v-src mutants.", "output": {"entities": {"gene": [{"text": "v-src mutants", "start": 106, "end": 119}]}}, "schema": []}
{"input": "Our results indicate that D (4) and D (2L) receptors activate the ERK kinase cascade by first mobilizing signaling by the PDGF receptor, followed by the subsequent activation of ERK1/2 by pathways associated with this receptor tyrosine kinase.", "output": {"entities": {"gene": [{"text": "ERK kinase", "start": 66, "end": 76}, {"text": "PDGF receptor", "start": 122, "end": 135}, {"text": "ERK1/2", "start": 178, "end": 184}, {"text": "receptor tyrosine kinase", "start": 218, "end": 242}]}}, "schema": []}
{"input": "Karger AG, Basel", "output": {"entities": {}}, "schema": []}
{"input": "NIRS was used for the quantitative measurement of muscle O (2) consumption (mV. O (2)) and forearm blood flow (FBF) in 78 healthy subjects.", "output": {"entities": {}}, "schema": []}
{"input": "No dominant clinical factor of risk was found, but multiple regression analysis identified age, body surface area, valve size, shop order fracture rate, and manufacturing period as risk factors for OSF.", "output": {"entities": {}}, "schema": []}
{"input": "In this report this technique was applied to human breast carcinoma MDA-MB231 cells overexpressing human MPG in order to assess whether up-regulation of the initial step in BER alters the activity of selected other BER (hOGG1 and APE/ref-1) or direct reversal (MGMT) repair activities.", "output": {"entities": {"gene": [{"text": "human MPG", "start": 99, "end": 108}, {"text": "hOGG1", "start": 220, "end": 225}, {"text": "APE", "start": 230, "end": 233}, {"text": "ref-1", "start": 234, "end": 239}, {"text": "MGMT", "start": 261, "end": 265}]}}, "schema": []}
{"input": "The selective alteration of the genome using Cre recombinase to target the rearrangement of genes flanked by LOX recognition sequences has required the use of two separate genetic constructs in trans, one containing cre and the other containing the gene of interest flanked by LOX sites.", "output": {"entities": {"gene": [{"text": "Cre recombinase", "start": 45, "end": 60}, {"text": "LOX recognition sequences", "start": 109, "end": 134}, {"text": "LOX sites", "start": 277, "end": 286}]}}, "schema": []}
{"input": "Influence of compression therapy on symptoms following soft tissue injury from maximal eccentric exercise.", "output": {"entities": {}}, "schema": []}
{"input": "Keratoconjunctivitis sicca appears to be a common ocular complication and all children with JRA should be screened for it with a comprehensive battery of tests.", "output": {"entities": {}}, "schema": []}
{"input": "STAT5A mutations in the Src homology 2 (SH2) and SH3 domains did not alter the BTK-mediated tyrosine phosphorylation.", "output": {"entities": {"gene": [{"text": "STAT5A", "start": 0, "end": 6}, {"text": "Src homology 2", "start": 24, "end": 38}, {"text": "SH2", "start": 40, "end": 43}, {"text": "SH3 domains", "start": 49, "end": 60}, {"text": "BTK", "start": 79, "end": 82}]}}, "schema": []}
{"input": "In conclusion, primary chemotherapy based on high dose MTX and ara-C is highly efficient in PCNSL.", "output": {"entities": {}}, "schema": []}
{"input": "Reovirus mRNAs are efficiently translated within host cells despite the absence of 3' polyadenylated tails.", "output": {"entities": {}}, "schema": []}
{"input": "Analyses revealed that scale matters above and beyond the effect of quadrat area.", "output": {"entities": {}}, "schema": []}
{"input": "Myasthenia gravis is an autoimmune disease resulting from the production of antibodies against the ACh receptors of the neuromuscular synapse.", "output": {"entities": {"gene": [{"text": "ACh receptors", "start": 99, "end": 112}]}}, "schema": []}
{"input": "Copyright 2001 Academic Press.", "output": {"entities": {}}, "schema": []}
{"input": "Using the postural and force data as input to a 3-D biomechanical model, the lumbosacral spinal compression was calculated.", "output": {"entities": {}}, "schema": []}
{"input": "Angina (Q) persistence showed marked associations with previous myocardial infarction, diagnosed angina, electrocardiogram ischemia, and subsequent major ischemic heart disease events from Q5 onward.", "output": {"entities": {}}, "schema": []}
{"input": "In the past decade, there have been enormous advances in the use of Bayesian methodology for analysis of epidemiologic data, and there are now many practical advantages to the Bayesian approach.", "output": {"entities": {}}, "schema": []}
{"input": "To assess more specific PKA-dependent mediation of LH' s contribution to combined hormonal drive, the LDL receptor (-1076 to + 11 bp) reporter plasmid was cotransfected with a full-sequence rabbit muscle protein kinase inhibitor (PKI) minigene driven constitutively by a Rous sarcoma virus promoter.", "output": {"entities": {"gene": [{"text": "PKA", "start": 24, "end": 27}, {"text": "LH' s", "start": 51, "end": 56}, {"text": "LDL receptor (-1076 to + 11 bp) reporter", "start": 102, "end": 142}, {"text": "full-sequence rabbit muscle protein kinase inhibitor", "start": 176, "end": 228}, {"text": "PKI", "start": 230, "end": 233}, {"text": "Rous sarcoma virus promoter", "start": 271, "end": 298}]}}, "schema": []}
{"input": "To investigate the convergent role of the insulin/IGF-I effector pathway mediating bihormonal stimulation of LDL receptor promoter expression, transfected granulosa-luteal cells were pretreated for 30 min with two specific inhibitors of phophatidylinositol 3-kinase, wortmannin (100 nM) and LY 294002 (10 microM), or of mitogen-activated protein kinase kinase, PD 98059 (50 microM), U0126 (10 microM), or the latter' s inactive derivative, U0124 (10 microM).", "output": {"entities": {"gene": [{"text": "insulin", "start": 42, "end": 49}, {"text": "IGF-I", "start": 50, "end": 55}, {"text": "LDL receptor promoter", "start": 109, "end": 130}, {"text": "phophatidylinositol 3-kinase", "start": 237, "end": 265}, {"text": "mitogen-activated protein kinase kinase", "start": 320, "end": 359}]}}, "schema": []}
{"input": "Concerted transcriptional activation of the low density lipoprotein receptor gene by insulin and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase a, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase signaling pathways.", "output": {"entities": {"gene": [{"text": "low density lipoprotein receptor gene", "start": 44, "end": 81}, {"text": "insulin", "start": 85, "end": 92}, {"text": "luteinizing hormone", "start": 97, "end": 116}, {"text": "protein kinase a", "start": 185, "end": 201}, {"text": "phosphatidylinositol 3-kinase", "start": 203, "end": 232}, {"text": "mitogen-activated protein kinase", "start": 238, "end": 270}]}}, "schema": []}
{"input": "These studies demonstrate that site-specific recognition of the bxd PRE by d (GA) (n) repeat binding activities mediates PcG-dependent silencing.", "output": {"entities": {"gene": [{"text": "bxd PRE", "start": 64, "end": 71}, {"text": "PcG", "start": 121, "end": 124}]}}, "schema": []}
{"input": "Our findings further our understanding of how ZBP-89 modulates cell proliferation and reveals a novel mechanism by which the p53 protein is stabilized.", "output": {"entities": {"gene": [{"text": "ZBP-89", "start": 46, "end": 52}, {"text": "p53 protein", "start": 125, "end": 136}]}}, "schema": []}
{"input": "A computerized method of determining the focal point of electrical activity in the pallidum of parkinsonian patients was developed using on-line quantitative physiological data analysis.", "output": {"entities": {}}, "schema": []}
{"input": "Isolated Systolic Hypertension: An Update.", "output": {"entities": {}}, "schema": []}
{"input": "The N-terminal portion of Notch (IC) inhibited p50 DNA binding and interacted specifically with p50 subunit, not p65 of NF-kappaB.", "output": {"entities": {"gene": [{"text": "Notch (IC)", "start": 26, "end": 36}, {"text": "p50", "start": 47, "end": 50}, {"text": "p50 subunit", "start": 96, "end": 107}, {"text": "p65", "start": 113, "end": 116}, {"text": "NF-kappaB", "start": 120, "end": 129}]}}, "schema": []}
{"input": "Conformational changes of the ferric uptake regulation protein upon metal activation and DNA binding; first evidence of structural homologies with the diphtheria toxin repressor.", "output": {"entities": {"gene": [{"text": "ferric uptake regulation protein", "start": 30, "end": 62}, {"text": "diphtheria toxin repressor", "start": 151, "end": 177}]}}, "schema": []}
{"input": "As a complement to genome-wide mapping and sequencing efforts, it is often important to generate detailed maps and sequence data for specific regions of interest.", "output": {"entities": {}}, "schema": []}
{"input": "Granulocyte colony-stimulating factor (G-CSF) administration in vivo has been shown to improve the defence mechanisms against infection by different microbes.", "output": {"entities": {"gene": [{"text": "Granulocyte colony-stimulating factor", "start": 0, "end": 37}, {"text": "G-CSF", "start": 39, "end": 44}]}}, "schema": []}
{"input": "Among individuals, however, changes were strongly correlated with ACR levels at baseline.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, the screen for toxic p53 mutants in yeast can identify novel p53 variants that may be useful in dissecting p53 regulated cellular responses and in developing p53-based cancer therapies.", "output": {"entities": {"gene": [{"text": "p53 mutants", "start": 27, "end": 38}, {"text": "p53", "start": 67, "end": 70}, {"text": "p53", "start": 113, "end": 116}, {"text": "p53", "start": 164, "end": 167}]}}, "schema": []}
{"input": "This is necessary if psychiatric diagnoses are ultimately going to be refined and validated against biological criteria.", "output": {"entities": {}}, "schema": []}
{"input": "Since the latter is very small for physiological flows, the result is that alpha < 1 even at relatively high values of the Reynolds number (i. e., for non-negligible inertia) and we validate our perturbation theory results by comparison with a numerical integration of the full model.", "output": {"entities": {}}, "schema": []}
{"input": "Cells lacking p116 exhibit a striking defect in the formation of these macropinocytic structures, a concomitant reduction in the rate of fluid phase pinocytosis, a significant decrease in the efficiency of chemotactic aggregation, and a decrease in cellular F-actin content.", "output": {"entities": {"gene": [{"text": "p116", "start": 14, "end": 18}, {"text": "F-actin", "start": 258, "end": 265}]}}, "schema": []}
{"input": "The validity of the FPS-R was further supported by strong positive correlations with the VAS (r = 0. 92, N = 45) and the CAS (r = 0. 84, N = 45) in this clinical sample.", "output": {"entities": {}}, "schema": []}
{"input": "The susceptibility of Aspergillus fumigatus to mulundocandin, an echinocandin-like compound, and other antifungal agents was assessed by the National Committee for Clinical Laboratory Standards (NCCLS) M38-P method, a 2, 3-bis (2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenyl-amino) carbonyl]-2H-tetrazolium hydroxide (XTT)-based colorimetric assay, and determination of morphologic alterations by microscopy.", "output": {"entities": {}}, "schema": []}
{"input": "DESIGN: A retrospective chart review of 9, 322 patients undergoing surgical procedures in the period January 1993 to December 1998.", "output": {"entities": {}}, "schema": []}
{"input": "Pulmonary vein varix in association with bilateral pulmonary vein stenosis.", "output": {"entities": {}}, "schema": []}
{"input": "Biochemical experiments have shown that CopG co-operatively associates to its target DNA at low protein: DNA ratios, completely protecting four helical turns on the same face of the double helix in both directions from the inverted repeat that constitutes the CopG primary target.", "output": {"entities": {"gene": [{"text": "CopG", "start": 40, "end": 44}, {"text": "CopG", "start": 260, "end": 264}]}}, "schema": []}
{"input": "We demonstrated that, under serum-starved conditions, KMS-11 and OPM-2 cells express appreciable levels of phosphorylated FGFR3 mutants indicating a constitutive activation of the Y373C and K650E receptors; the addition of the aFGF ligand further increased the level of receptor phosphorylation.", "output": {"entities": {"gene": [{"text": "FGFR3 mutants", "start": 122, "end": 135}, {"text": "Y373C and K650E receptors", "start": 180, "end": 205}, {"text": "aFGF ligand", "start": 227, "end": 238}]}}, "schema": []}
{"input": "[figure: see text] The Stille coupling reaction has been performed in 1-butyl-3-methylimidazolium tetrafluoroborate (BMIM BF4), a room-temperature ionic liquid (RTIL).", "output": {"entities": {}}, "schema": []}
{"input": "Special issues devoted to the biosynthesis of woody plant biopolymers and related substances.", "output": {"entities": {}}, "schema": []}
{"input": "Interactions between the checkpoint abrogator UCN-01 and several pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase (MEK)/MAPK pathway have been examined in a variety of human leukemia cell lines.", "output": {"entities": {"gene": [{"text": "mitogen-activated protein kinase (MAPK) kinase", "start": 99, "end": 145}, {"text": "MEK", "start": 147, "end": 150}, {"text": "MAPK", "start": 152, "end": 156}]}}, "schema": []}
{"input": "Low affinity binding of Rab6A-GTP was also observed (K (d) = 16 microm), whereas Rab1B,-5,-7,-8, or-11A did not bind.", "output": {"entities": {"gene": [{"text": "Rab6A-GTP", "start": 24, "end": 33}, {"text": "Rab1B,-5,-7,-8, or-11A", "start": 81, "end": 103}]}}, "schema": []}
{"input": "The students who had abnormal urine screening results at the first time received a second urine analysis 10 to 15 days later to confirm the abnormal urine analysis.", "output": {"entities": {}}, "schema": []}
{"input": "Regulation of laminin beta2 chain gene expression in human cancer cell lines.", "output": {"entities": {"gene": [{"text": "laminin beta2 chain gene", "start": 14, "end": 38}]}}, "schema": []}
{"input": "Northern and Western blot analyses demonstrated that Graf2 is expressed in several tissues, with the highest expression in skeletal muscle.", "output": {"entities": {"gene": [{"text": "Graf2", "start": 53, "end": 58}]}}, "schema": []}
{"input": "However, when directed to the nucleosome by fusion to core histone H2A or H2B, the non-histone tail forms an MCB that appears identical to that of the endogenous protein.", "output": {"entities": {"gene": [{"text": "core histone H2A", "start": 54, "end": 70}, {"text": "H2B", "start": 74, "end": 77}, {"text": "histone", "start": 87, "end": 94}]}}, "schema": []}
{"input": "These data suggest that proper direct binding of Nhp2p to H/ACA snoRNAs is required for the assembly of H/ACA snoRNPs and hence for the stability of some of their components.", "output": {"entities": {"gene": [{"text": "Nhp2p", "start": 49, "end": 54}, {"text": "H/ACA snoRNAs", "start": 58, "end": 71}, {"text": "H/ACA snoRNPs", "start": 104, "end": 117}]}}, "schema": []}
{"input": "Telomerase is a ribonucleoprotein complex that synthesizes telomeric DNA onto chromosomes using its RNA component as template.", "output": {"entities": {"gene": [{"text": "Telomerase", "start": 0, "end": 10}]}}, "schema": []}
{"input": "SIT (SHP2-interacting transmembrane adaptor protein) is a recently identified transmembrane adaptor protein, which is expressed in lymphocytes.", "output": {"entities": {"gene": [{"text": "SIT", "start": 0, "end": 3}, {"text": "SHP2-interacting transmembrane adaptor protein", "start": 5, "end": 51}]}}, "schema": []}
{"input": "Ileal digestibilities of DM, OM, CP, total dietary fiber (TDF), fat and gross energy (GE) were lower (P < 0. 05) for dogs fed diets containing supplemental fiber compared with dogs fed the control diet.", "output": {"entities": {}}, "schema": []}
{"input": "Together these data imply that the HFV R region acts in the nucleus to modify the cytoplasmic fate of target HFV mRNA.", "output": {"entities": {"gene": [{"text": "HFV R region", "start": 35, "end": 47}]}}, "schema": []}
{"input": "These TxRE contain cyclic AMP-responsive elements (CRE), but, remarkably, the \" TGACGTCA \" consensus is never strictly conserved in any viral strain (e. g., AGACGTCA, TGACGGCA, TGACCTCA).", "output": {"entities": {"gene": [{"text": "TxRE", "start": 6, "end": 10}]}}, "schema": []}
{"input": "And, most importantly, reconstitution of a consensus CRE, within the 21-bp enhancers increases binding of CREB/ATF proteins but abrogates basal repression of LTR-directed transcription in vitro.", "output": {"entities": {"gene": [{"text": "CREB", "start": 106, "end": 110}, {"text": "ATF", "start": 111, "end": 114}]}}, "schema": []}
{"input": "Site-directed mutagenesis of CAR revealed that CAR residues Leu73 and Lys121 and/or Lys123 are critical contact residues, with Tyr80 and Tyr83 being peripherally involved in the binding interaction with the Ad5, Ad9, Ad12, and Ad41L fiber knobs.", "output": {"entities": {"gene": [{"text": "CAR", "start": 29, "end": 32}, {"text": "CAR", "start": 47, "end": 50}, {"text": "Ad5, Ad9, Ad12, and Ad41L fiber knobs", "start": 207, "end": 244}]}}, "schema": []}
{"input": "This subfamily of genes all have a single ATP-binding domain at the N-terminus and a single C-terminal set of transmembrane segments.", "output": {"entities": {}}, "schema": []}
{"input": "The promoter activity of the proximal region was found to be restricted to a subset of prestalk cells.", "output": {"entities": {}}, "schema": []}
{"input": "Substitution of serine residues at the C-terminus indicated that loss of phosphorylation sites did not appear to have any effect on transcription and replication.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, replication fork movement near HML pauses at a silent origin which is competent for replication initiation but kept silent through Orc2p, a component of the replication initiator.", "output": {"entities": {"gene": [{"text": "HML", "start": 37, "end": 40}, {"text": "Orc2p", "start": 137, "end": 142}]}}, "schema": []}
{"input": "These findings suggest that the adapter Gab1 may redirect c-Met signaling through PI3K away from a c-Akt/Pak1 cell survival pathway.", "output": {"entities": {"gene": [{"text": "Gab1", "start": 40, "end": 44}, {"text": "c-Met", "start": 58, "end": 63}, {"text": "PI3K", "start": 82, "end": 86}, {"text": "c-Akt", "start": 99, "end": 104}, {"text": "Pak1", "start": 105, "end": 109}]}}, "schema": []}
{"input": "We have cloned a novel mouse protein, TAF (II) 140, containing an HFD and a plant homeodomain (PHD) finger, which we demonstrated by immunoprecipitation to be a mammalian TFIID component.", "output": {"entities": {"gene": [{"text": "TAF (II) 140", "start": 38, "end": 50}, {"text": "HFD", "start": 66, "end": 69}, {"text": "plant homeodomain", "start": 76, "end": 93}, {"text": "PHD", "start": 95, "end": 98}, {"text": "mammalian TFIID component", "start": 161, "end": 186}]}}, "schema": []}
{"input": "The other inhibitor was a single TAR decoy, driven by the U6 small nuclear RNA promoter (U6-P).", "output": {"entities": {"gene": [{"text": "TAR", "start": 33, "end": 36}, {"text": "U6 small nuclear RNA promoter", "start": 58, "end": 87}, {"text": "U6-P", "start": 89, "end": 93}]}}, "schema": []}
{"input": "In contrast to MPc3, data indicate that the Pc protein M33 does not interact with AF9.", "output": {"entities": {"gene": [{"text": "MPc3", "start": 15, "end": 19}, {"text": "Pc protein M33", "start": 44, "end": 58}, {"text": "AF9", "start": 82, "end": 85}]}}, "schema": []}
{"input": "Long-term results with MACOP-B and radiation therapy for aggressive lymphomas] BACKGROUND: Long-term results are needed to evaluate chemotherapy regimens and prognostic factors in non-Hodgkin' s lymphomas (NHL).", "output": {"entities": {}}, "schema": []}
{"input": "At 20 days (D) and at 3 months post-TBI, irradiated rats had a significantly lower percentage of avoidance than controls but no statistical difference was found at 5 months post-TBI. b/Two-way avoidance test: this test was performed only after TBI.", "output": {"entities": {}}, "schema": []}
{"input": "At the end of each day of migration the pulmonary hemolymph PO2 decreased by 1-2. 5 kPa, but the hemocyanin remained saturated with O2 and the venous reserve was largely unchanged (O2 > 0. 4 mmol x l (-1)).", "output": {"entities": {}}, "schema": []}
{"input": "DESIGN: Prospective cohort study with a 20 y follow-up period, the First National Health and Examination Survey (NHANES 1) Epidemiologic Follow-up Study (NHEFS).", "output": {"entities": {}}, "schema": []}
{"input": "Mean Hg concentrations in the livers of mice at some sites in Isle Royale are not significantly lower (P = 0. 62) than Hg concentrations considered by some government agencies to be unhealthy for human consumption.", "output": {"entities": {}}, "schema": []}
{"input": "There are many different proposals for the statistical analysis of data to determine early onset of action.", "output": {"entities": {}}, "schema": []}
{"input": "The assay herein described allows the comparison of relative FGFR expression levels, both within a single RNA pool and among multiple RNA pool samples.", "output": {"entities": {"gene": [{"text": "FGFR", "start": 61, "end": 65}]}}, "schema": []}
{"input": "The amount of drained effusion was measured, and fluid was sent for diagnostic assessment.", "output": {"entities": {}}, "schema": []}
{"input": "The system, designed to exploit the relatively constant small intestine transit time, consists of a drug-containing core coated with a polymeric matrix formed by a channeling agent (NaCl, mannitol, and Emdex) and an inert polymer (Eudragit RS100).", "output": {"entities": {}}, "schema": []}
{"input": "STUDY OBJECTIVE: This study assessed several methodological aspects related to the quality of published controlled clinical trials (CCTs) in relation to the participation of an epidemiologist/biostatistician (E/B).", "output": {"entities": {}}, "schema": []}
{"input": "The median preoperative best-corrected visual acuity of 0. 08 (range hand motions/0. 003 to 0. 4), improved by 5 lines to a median final postoperative best-corrected visual acuity of 0. 25 (range 0. 025-0. 5) (P = 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "A rare case of primary group A streptococcal peritonitis.", "output": {"entities": {}}, "schema": []}
{"input": "Gimpl, F.", "output": {"entities": {}}, "schema": []}
{"input": "BACKGROUND/AIMS: Hepatitis C and nonalcoholic fatty liver disease (NAFL) are the two most common forms of liver disease in the United States.", "output": {"entities": {}}, "schema": []}
{"input": "Statistical Analysis included ANOVA, the Pearson Product Moment Correlation Coefficient, Principal Components Analysis and Discriminant Function Analysis and the calculation of Cronbach' s alpha (alpha) RESULTS: Both Sensitivity and specificity exceed 90. 00 at 23/24, Chronbach' s alpha for the total scale was equal to 0. 95.", "output": {"entities": {}}, "schema": []}
{"input": "The titer of TSH binding inhibitor immunoglobulin (TBII), which had been 8. 6% at initial presentation, rose to 14. 9% in 2 weeks.", "output": {"entities": {"gene": [{"text": "TSH binding inhibitor immunoglobulin", "start": 13, "end": 49}, {"text": "TBII", "start": 51, "end": 55}]}}, "schema": []}
{"input": "Here we show that independent of uncertainties in the models, terrestrial planets with dense atmosphere like Venus can evolve into one of only four possible rotation states.", "output": {"entities": {}}, "schema": []}
{"input": "Enantiomer separation of venlafaxine and O-desmethylvenlafaxine in human plasma.", "output": {"entities": {}}, "schema": []}
{"input": "TE-671 cells that were transfected with cAMP response element mutant constructs demonstrated a diminished basal activity of the GnRH-II promoter.", "output": {"entities": {"gene": [{"text": "GnRH-II promoter", "start": 128, "end": 144}]}}, "schema": []}
{"input": "They consist of at least two separable components, one heat stable and the other heat labile.", "output": {"entities": {}}, "schema": []}
{"input": "Altogether, we confirm that all genes of the Rad52 recombinational repair pathway are required for the survival of rad27 Delta strains at both permissive (23 degrees C) and semipermissive (30 degrees C) temperatures for growth.", "output": {"entities": {"gene": [{"text": "Rad52", "start": 45, "end": 50}, {"text": "rad27 Delta", "start": 115, "end": 126}]}}, "schema": []}
{"input": "In the last case, both hydroxychloroquine, carbamazepine and fluvoxamine had a common imputability which was plausible.", "output": {"entities": {}}, "schema": []}
{"input": "We investigate the reaction kinetics of small spherical particles with inertia, obeying coalescence type of reaction, B + B--> B, and being advected by hydrodynamical flows with time-periodic forcing.", "output": {"entities": {}}, "schema": []}
{"input": "The role of the Vp1 DBD during infection was investigated by taking advantage of NLS phenotypic complementation (N.", "output": {"entities": {"gene": [{"text": "Vp1 DBD", "start": 16, "end": 23}]}}, "schema": []}
{"input": "2 were nonviable, and the mutant Vp1s unexpectedly failed to localize to the nucleus though Vp2 and Vp3 did, suggesting that the mutated NLS1 acted as a dominant signal for the cytoplasmic localization of Vp1.", "output": {"entities": {"gene": [{"text": "mutant Vp1s", "start": 26, "end": 37}, {"text": "Vp2", "start": 92, "end": 95}, {"text": "Vp3", "start": 100, "end": 103}, {"text": "mutated NLS1", "start": 129, "end": 141}, {"text": "Vp1", "start": 205, "end": 208}]}}, "schema": []}
{"input": "Fasting gastrin levels (normal range: 25-110 mU/L) varied from 48. 78 mU/L-168. 20 (mean: 85. 23 mU/L).", "output": {"entities": {"gene": [{"text": "gastrin", "start": 8, "end": 15}]}}, "schema": []}
{"input": "Here, we show that the phorbol ester PMA decreases both basal and dexamethasone/cAMP-induced expression of a luciferase gene under the control of the G6Pase promoter in transiently transfected H4IIE hepatoma cells.", "output": {"entities": {"gene": [{"text": "luciferase gene", "start": 109, "end": 124}, {"text": "G6Pase promoter", "start": 150, "end": 165}]}}, "schema": []}
{"input": "Through deletion mutagenesis, we identify amino acids 2003 to 2212 of CBP, which we call carboxy-terminal region 2 (CR2), as the minimal region for Tax interaction.", "output": {"entities": {"gene": [{"text": "CBP", "start": 70, "end": 73}, {"text": "Tax", "start": 148, "end": 151}]}}, "schema": []}
{"input": "Such knowledge could advance diagnosis and treatment of the patient and counseling of the affected family.", "output": {"entities": {}}, "schema": []}
{"input": "BACKGROUND: There is increasing interest on the part of investigators and the public at large in finding ways to study and improve treatments for the seriously mentally ill without exposing such individuals to unnecessary risks.", "output": {"entities": {}}, "schema": []}
{"input": "In the next week, the beta-adrenergic antagonist atenolol was added at an initial dose of 25 mg/day and titrated to 50 mg/day within 1 week.", "output": {"entities": {}}, "schema": []}
{"input": "Lack of association between Kawasaki syndrome and infection with Rickettsia conorii, Rickettsia typhi, Coxiella burnetii or Ehrlichia phagocytophila group.", "output": {"entities": {}}, "schema": []}
{"input": "The presence of AS-oligo had no further effect on the FSH-mediated activation of the EB *-mTf-CAT construct but reduced cAMP-mediated activation.", "output": {"entities": {"gene": [{"text": "FSH", "start": 54, "end": 57}, {"text": "mTf", "start": 90, "end": 93}, {"text": "CAT", "start": 94, "end": 97}]}}, "schema": []}
{"input": "This is a challenging task insofar as direct measures of ISF glucose are not readily available.", "output": {"entities": {}}, "schema": []}
{"input": "We report the results of a detailed policy analysis comparing 2 CJD-related decisions: a 1995 recall of blood from a donor with classic CJD and the 1999 decision to defer donations from individuals with a 6-month travel history to the UK between 1980 and 1996 due to concerns related to variant CJD.", "output": {"entities": {}}, "schema": []}
{"input": "At visit 5, the isokinetic test showed impaired muscle function recovery from 23% to 32%, while the manual test showed almost full recovery.", "output": {"entities": {}}, "schema": []}
{"input": "We developed a system for domain shuffling to establish the function of C1 domains from human Raf kinase and rat PKC eta in yeast.", "output": {"entities": {"gene": [{"text": "C1", "start": 72, "end": 74}, {"text": "human Raf kinase", "start": 88, "end": 104}, {"text": "rat PKC eta", "start": 109, "end": 120}]}}, "schema": []}
{"input": "We interpret these data as further evidence that interaction with a small GTPase is the main regulatory function of the C1 domain in yeast.", "output": {"entities": {"gene": [{"text": "small GTPase", "start": 68, "end": 80}, {"text": "C1", "start": 120, "end": 122}]}}, "schema": []}
{"input": "Breast cancer risk assessment: Who holds the magic crystal ball?", "output": {"entities": {}}, "schema": []}
{"input": "Patients with type III SOD may have visceral hyperalgesia; a trial of antidepressants or a therapeutic trial with botulinum toxin injection into the ampulla should be considered prior to more invasive endoscopic therapy.", "output": {"entities": {"gene": [{"text": "botulinum toxin", "start": 114, "end": 129}]}}, "schema": []}
{"input": "RESULTS: There is a considerable amount of variation between the results of TRA1 and TRA2 and between the results of both TRA' s and the door-to-door survey.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, these patients show both quantitative and qualitative differences in their infectious microbiological spectrum, mainly in clean-contaminated, contaminated and dirty surgical procedures.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSION: Extrusion cooking is effective for the inactivation of DON but is of limited value for AFB1, even if metabisulphite is added.", "output": {"entities": {"gene": [{"text": "AFB1", "start": 99, "end": 103}]}}, "schema": []}
{"input": "The differences in the CPIgG, CRP, and fibrinogen levels in patients who were diagnosed with ACS versus those who were not (non-ACS) were evaluated.", "output": {"entities": {"gene": [{"text": "CPIgG", "start": 23, "end": 28}, {"text": "CRP", "start": 30, "end": 33}, {"text": "fibrinogen", "start": 39, "end": 49}]}}, "schema": []}
{"input": "NaeI, a novel DNA endonuclease, shows topoisomerase and recombinase activities when a Lys residue is substituted for Leu 43.", "output": {"entities": {"gene": [{"text": "NaeI", "start": 0, "end": 4}, {"text": "DNA endonuclease", "start": 14, "end": 30}, {"text": "topoisomerase", "start": 38, "end": 51}, {"text": "recombinase", "start": 56, "end": 67}]}}, "schema": []}
{"input": "The decrements in cerebrovascular resistance induced by hexamethonium, in mm Hg ml (-1). min (-1), were: under control.", "output": {"entities": {}}, "schema": []}
{"input": "The desirability function is based on the search for a global optimum [D = f (Y1, Y2,..., Yn)] by the transformation of the measured property to a dimensionless scale for each criterion.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: In vivo, there was a wide distribution with the coefficient of variation (SD/mean x 100%) for different valve sizes ranging from 21% to 39% in the St Jude Medical valve and from 25% to 33% in the Omnicarbon valve.", "output": {"entities": {}}, "schema": []}
{"input": "Even if the electrocardiographic signs are subdued, the underlying blockade of I (Kr) current may precipitate the occurrence of arrhythmia.", "output": {"entities": {}}, "schema": []}
{"input": "The production of ceramide is emerging as a fixture of programmed cell death.", "output": {"entities": {}}, "schema": []}
{"input": "We randomly assigned 1, 219 subjects to receive either the standard three-times-weekly (TIW) interferon alfa-2b dose (3 MIU) or the once-weekly (QW) peginterferon alfa-2b (0. 5, 1. 0, or 1. 5 microg/kg).", "output": {"entities": {"gene": [{"text": "interferon alfa-2b", "start": 93, "end": 111}, {"text": "peginterferon alfa-2b", "start": 149, "end": 170}]}}, "schema": []}
{"input": "At cross purposes.", "output": {"entities": {}}, "schema": []}
{"input": "Among the transcription factors known to interact with Groucho-related protein, only RUNX1 was appreciably downregulated by E2A-HLF.", "output": {"entities": {"gene": [{"text": "Groucho-related protein", "start": 55, "end": 78}, {"text": "RUNX1", "start": 85, "end": 90}, {"text": "E2A", "start": 124, "end": 127}, {"text": "HLF", "start": 128, "end": 131}]}}, "schema": []}
{"input": "The combination of ifosfamide, epirubicin and etoposide (IEV) is an effective salvage regimen for lymphoproliferative disease.", "output": {"entities": {}}, "schema": []}
{"input": "A prospective trial was undertaken to determine (1) clinical characteristics of patients with chest pain; (2) value of cardiac markers troponin T, myoglobin and CK-MB mass in differentiating cardiac and noncardiac chest pain; (3) the proportion of patients with ACS in whom these markers provided helpful additional information on admission and afterwards.", "output": {"entities": {"gene": [{"text": "troponin T", "start": 135, "end": 145}, {"text": "myoglobin", "start": 147, "end": 156}, {"text": "CK", "start": 161, "end": 163}, {"text": "MB", "start": 164, "end": 166}]}}, "schema": []}
{"input": "Cardiac markers troponin T, CK-MB mass and myoglobin were helpful in the differential diagnosis of chest pain, even when the ECG was unremarkable or nonspecific.", "output": {"entities": {"gene": [{"text": "troponin T", "start": 16, "end": 26}, {"text": "CK", "start": 28, "end": 30}, {"text": "MB", "start": 31, "end": 33}, {"text": "myoglobin", "start": 43, "end": 52}]}}, "schema": []}
{"input": "At termination (gd 20), confirmed-pregnant females (21 to 25 per group) were evaluated for clinical status and gestational outcome; live fetuses were examined for external, visceral, and skeletal malformations.", "output": {"entities": {}}, "schema": []}
{"input": "One maternal death, reduced body weight, and reduced weight gain were noted at the high dose; confirmed pregnancy rates were 84 to 100% for each group.", "output": {"entities": {}}, "schema": []}
{"input": "In the further development of bladder neck suspension according to Stamey-Pereyra, the use of miniature bone anchors received considerable support.", "output": {"entities": {}}, "schema": []}
{"input": "Simulating the impact during human jumping by means of a 4-degrees-of-freedom model with time-dependent properties.", "output": {"entities": {}}, "schema": []}
{"input": "A 1-base pair mismatch within the corresponding region of the CYP3A4 gene was sufficient for a differential enhancer activity.", "output": {"entities": {"gene": [{"text": "CYP3A4 gene", "start": 62, "end": 73}]}}, "schema": []}
{"input": "The authors made an analysis of social-economical conditions limiting the possibilities of rendering cardiosurgical care to children.", "output": {"entities": {}}, "schema": []}
{"input": "METHODS: 93 female and 43 male patients undergoing thyroid surgery were stratified according to gender and then randomised to receive double-blind one of four antiemetic regimes: 50 mg dolasetron given orally 45 minutes prior to induction of anaesthesia (group I), 12. 5 mg dolasetron given intravenously during induction of anaesthesia (group II), 1. 25 mg DHB given intravenously during induction of anaesthesia (group III) or placebo (group IV).", "output": {"entities": {"gene": [{"text": "DHB", "start": 358, "end": 361}]}}, "schema": []}
{"input": "This slow progression through the early G1-phase resulted in decreased phosphorylation of the RB protein and subsequent delay into the S phase transition.", "output": {"entities": {"gene": [{"text": "RB protein", "start": 94, "end": 104}]}}, "schema": []}
{"input": "In mammals, the transcriptional repressors in the Wnt pathway are not well defined.", "output": {"entities": {"gene": [{"text": "Wnt", "start": 50, "end": 53}]}}, "schema": []}
{"input": "Despite abundant expression of NtmybAS transcripts in mature pollen, gPAL1 transcripts were not detectable in pollen.", "output": {"entities": {"gene": [{"text": "NtmybAS transcripts", "start": 31, "end": 50}, {"text": "gPAL1 transcripts", "start": 69, "end": 86}]}}, "schema": []}
{"input": "Identical effects were obtained when inhibitors and dominant negative mutants were tested on the-29 to + 139 bp region of the cyclin D1 promoter.", "output": {"entities": {"gene": [{"text": "cyclin D1 promoter", "start": 126, "end": 144}]}}, "schema": []}
{"input": "These findings suggest a novel ankyrin-independent role for LAD-1 related to FGFR signaling.", "output": {"entities": {"gene": [{"text": "ankyrin", "start": 31, "end": 38}, {"text": "LAD-1", "start": 60, "end": 65}, {"text": "FGFR", "start": 77, "end": 81}]}}, "schema": []}
{"input": "Moreover, elderly men with bioavailable estradiol levels below the median [40 pmol/liter (11 pg/ml)] had significantly higher rates of bone loss and levels of bone resorption markers than men with bioavailable estradiol levels above 40 pmol/liter.", "output": {"entities": {}}, "schema": []}
{"input": "Competition electrophoretic mobility shift and immunoshift assays confirmed that NF1 factors present in nuclear extracts of HeLa and CV-1 cells bind to the BKV-MLP.", "output": {"entities": {"gene": [{"text": "NF1 factors", "start": 81, "end": 92}, {"text": "BKV-MLP", "start": 156, "end": 163}]}}, "schema": []}
{"input": "This study demonstrates that inducible expression in response to either PMA or TPO is mediated through the Ets site in the proximal promoter of GPIX and is dependent upon the upstream activation of MAPK/extracellular signal-regulated kinase.", "output": {"entities": {"gene": [{"text": "TPO", "start": 79, "end": 82}, {"text": "Ets site", "start": 107, "end": 115}, {"text": "GPIX", "start": 144, "end": 148}, {"text": "MAPK", "start": 198, "end": 202}, {"text": "extracellular signal-regulated kinase", "start": 203, "end": 240}]}}, "schema": []}
{"input": "RESULTS: The analyzed fragment has significant activity in EpCAM positive cells, and it is regulated negatively by tumor necrosis factor alpha (TNFalpha).", "output": {"entities": {"gene": [{"text": "EpCAM", "start": 59, "end": 64}, {"text": "tumor necrosis factor alpha", "start": 115, "end": 142}, {"text": "TNFalpha", "start": 144, "end": 152}]}}, "schema": []}
{"input": "On Cox proportional hazards regression adenocarcinoma (P = 0. 006), the development of BPF (P = 0. 003), older age (P = 0. 03) and higher pathological stage (P = 0. 02) were independent adverse predictors of survival.", "output": {"entities": {}}, "schema": []}
{"input": "Phosphatidylinositol 3-kinase potentiates, but does not trigger, T cell proliferation mediated by the IL-2 receptor.", "output": {"entities": {"gene": [{"text": "Phosphatidylinositol 3-kinase", "start": 0, "end": 29}, {"text": "IL-2 receptor", "start": 102, "end": 115}]}}, "schema": []}
{"input": "In the stable transfectants (BM3 cells) expressing a mutant bacterial P450 AA epoxygenase, F87V BM3, which was genetically engineered to metabolize arachidonic acid only to 14, 15-EET, AA did not induce apoptosis and protected against agonist-induced apoptosis.", "output": {"entities": {"gene": [{"text": "mutant bacterial P450 AA epoxygenase", "start": 53, "end": 89}]}}, "schema": []}
{"input": "The loop domain of heat shock transcription factor 1 dictates DNA-binding specificity and responses to heat stress.", "output": {"entities": {"gene": [{"text": "heat shock transcription factor 1", "start": 19, "end": 52}]}}, "schema": []}
{"input": "Progressive study and robustness test of QSAR model based on quantum chemical parameters for predicting BCF of selected polychlorinated organic compounds (PCOCs).", "output": {"entities": {}}, "schema": []}
{"input": "Of the six cases of malignant polyposis, none were identified using CT, and only two were diagnosed by small bowel follow-through.", "output": {"entities": {}}, "schema": []}
{"input": "Using the two-hybrid system, we show that nonprenylated Rac1 interacts very weakly with Rho-GDI, pointing to the predominant role of protein-isoprene interaction in complex formation.", "output": {"entities": {"gene": [{"text": "Rac1", "start": 56, "end": 60}, {"text": "Rho-GDI", "start": 88, "end": 95}]}}, "schema": []}
{"input": "The patterns of early mRNA and protein expression in these seven mutants were examined, and it was found that mutation of the T' (135) acceptor site resulted in the utilization of cryptic splice sites and the generation of new T' species.", "output": {"entities": {"gene": [{"text": "T' (135)", "start": 126, "end": 134}, {"text": "T'", "start": 227, "end": 229}]}}, "schema": []}
{"input": "Sixty-one cases of cholera, all caused by V. cholerae O1, were reported.", "output": {"entities": {}}, "schema": []}
{"input": "Subsequently, these coordinates must be interpreted to define particular tissues and organs.", "output": {"entities": {}}, "schema": []}
{"input": "Testing was associated with a history of nonsexual risk behavior, increased knowledge of the hepatitis C virus, and healthcare provider communication.", "output": {"entities": {}}, "schema": []}
{"input": "Low-selenium diet has a human unfavourable impact.", "output": {"entities": {}}, "schema": []}
{"input": "Thus, BALB/c mice appear to be the most appropriate strain of mice to perform studies on the possible connection between infection with T. canis and allergic asthma.", "output": {"entities": {}}, "schema": []}
{"input": "Furthermore, hormonal regulation of G (1) gene transcription can occur even without additional activation of the Mek-Erk1/2 pathway by estrogen receptors.", "output": {"entities": {"gene": [{"text": "Mek", "start": 113, "end": 116}, {"text": "Erk1/2", "start": 117, "end": 123}, {"text": "estrogen receptors", "start": 135, "end": 153}]}}, "schema": []}
{"input": "Therefore, to understand how ErbB1/ErbB2 signaling contributes to this process, we used the ErbB kinase inhibitor AG1478in ErbB2-dependent BT-474 and SKBR-3 human breast cancer cells.", "output": {"entities": {"gene": [{"text": "ErbB1", "start": 29, "end": 34}, {"text": "ErbB2", "start": 35, "end": 40}, {"text": "ErbB kinase", "start": 92, "end": 103}, {"text": "ErbB2", "start": 123, "end": 128}]}}, "schema": []}
{"input": "This plus the reduced phosphorylation of p27 by MAPK enhanced the stability of p27 that associated with nuclear Cdk2 at high stoichiometry and inhibited its kinase activity.", "output": {"entities": {"gene": [{"text": "p27", "start": 41, "end": 44}, {"text": "MAPK", "start": 48, "end": 52}, {"text": "p27", "start": 79, "end": 82}, {"text": "nuclear Cdk2", "start": 104, "end": 116}]}}, "schema": []}
{"input": "ICA in the reference solution was characterised by LC and time-of-flight (TOF) MS and quantified by LC chemiluminescent nitrogen detection (LC-CLND).", "output": {"entities": {}}, "schema": []}
{"input": "Forced expression of BZAP45 strongly stimulates H4 promoter (nt-215 to-1)/CAT reporter gene activity.", "output": {"entities": {"gene": [{"text": "BZAP45", "start": 21, "end": 27}, {"text": "H4 promoter", "start": 48, "end": 59}, {"text": "CAT", "start": 74, "end": 77}]}}, "schema": []}
{"input": "Local control rates were 91% for metastatic lung cancer, 89% for primary lung cancer and 85% for T1, 2N0M0 cases.", "output": {"entities": {}}, "schema": []}
{"input": "Utility of OAE screener (GSI 70) for the evaluation of distortion product otoacoustic emissions] The purpose of this study was to investigate the ability of the OAE screener GSI 70 to evaluate of cochlea function in neonates, infants and adults.", "output": {"entities": {}}, "schema": []}
{"input": "For the sample of systematic reviews drawn from ACP Journal Club (n = 103), the PubMed strategy achieved a sensitivity of 97% (CI, 91% to 99%).", "output": {"entities": {}}, "schema": []}
{"input": "Inhibition of JNK1 and ERK kinase activities either by expression of the dominant negative mutant JNK1 or by treatment with a selective chemical inhibitor of ERK (PD098059) substantially abrogates the UV induction of the GADD45 promoter.", "output": {"entities": {"gene": [{"text": "JNK1", "start": 14, "end": 18}, {"text": "ERK", "start": 23, "end": 26}, {"text": "JNK1", "start": 98, "end": 102}, {"text": "ERK", "start": 158, "end": 161}, {"text": "GADD45 promoter", "start": 221, "end": 236}]}}, "schema": []}
{"input": "With a GC content of 45% the one segment would correspond to \" isochore H1 \" and the other segment (39% GC in human, 40% GC in mouse) to \" isochore L1/L2 \".", "output": {"entities": {"gene": [{"text": "\" isochore H1 \"", "start": 61, "end": 76}, {"text": "L1", "start": 148, "end": 150}, {"text": "L2", "start": 151, "end": 153}]}}, "schema": []}
{"input": "No mutation of the NRL gene was found in any of the two families.", "output": {"entities": {"gene": [{"text": "NRL gene", "start": 19, "end": 27}]}}, "schema": []}
{"input": "After nerve injury, the nociceptive responses through type I neurons, which are polymodal C-fibers and drive NK1-receptor mechanisms in spinal pain transmission, were completely lost, but without changes in type II ones, which are polymodal C-fibers and drive NMDA receptor-mechanisms, while type III ones, which are capsaicin-insensitive (possibly A-fibers) and drive NMDA-receptor mechanisms, were markedly enhanced.", "output": {"entities": {"gene": [{"text": "NK1-receptor", "start": 109, "end": 121}, {"text": "NMDA receptor", "start": 260, "end": 273}, {"text": "NMDA-receptor", "start": 369, "end": 382}]}}, "schema": []}
{"input": "This article reports the design and development of an ECG simulator intended for use in the testing, calibration and maintenance of electrocardiographic equipment.", "output": {"entities": {}}, "schema": []}
{"input": "Subacute diencephalic angioencephalopathy (SDAE) is a rare and fatal disease of unknown etiology that involves the thalami bilaterally.", "output": {"entities": {}}, "schema": []}
{"input": "Third, consistent with these data, N-acetylcysteine reduced the stimulatory effect of HGF on stress kinase activities, while p42/44 mitogen activated kinase (MAPK) was unmodified, suggesting an involvement of c-Jun-N-terminal kinase (JNK) and p38 MAPK in HIF-1 activation.", "output": {"entities": {"gene": [{"text": "HGF", "start": 86, "end": 89}, {"text": "stress kinase", "start": 93, "end": 106}, {"text": "p42/44", "start": 125, "end": 131}, {"text": "c-Jun-N-terminal kinase", "start": 209, "end": 232}, {"text": "JNK", "start": 234, "end": 237}, {"text": "p38", "start": 243, "end": 246}, {"text": "HIF-1", "start": 255, "end": 260}]}}, "schema": []}
{"input": "There was no significant difference in developmental scores at 9 or 18 months, although PDF infants had a 2. 8 (-1. 3-6. 8) point advantage in Bayley motor score scales.", "output": {"entities": {}}, "schema": []}
{"input": "In the single case the restoration of a structured daily routine represents the presupposition for a cognitive therapy.", "output": {"entities": {}}, "schema": []}
{"input": "However these search engines respond with such cumbersome results that domain specific experts can not tolerate.", "output": {"entities": {}}, "schema": []}
{"input": "The binary and tertiary combinations of plant-derived molluscicides Azadirachta indica and Cedrus deodara oil with synergists MGK-264, piperonyl butoxide (PB) and fruit powder of Embelia ribes were used against the Lymnaea acuminata.", "output": {"entities": {}}, "schema": []}
{"input": "From the above results, we might infer that the seizure type of TLE and a high frequency of seizure are two major independent precipitate factors for abnormal latencies of P300 in the epileptic patients.", "output": {"entities": {}}, "schema": []}
{"input": "Audiological findings in pregnancy.", "output": {"entities": {}}, "schema": []}
{"input": "The deubiquitinating enzyme DUB-2 is induced in response to IL-2 but as yet its function has not been determined.", "output": {"entities": {"gene": [{"text": "DUB-2", "start": 28, "end": 33}, {"text": "IL-2", "start": 60, "end": 64}]}}, "schema": []}
{"input": "The isoform, designated HDAC9a, is 132 aa shorter at the C terminus than HDAC9.", "output": {"entities": {"gene": [{"text": "HDAC9a", "start": 24, "end": 30}, {"text": "HDAC9", "start": 73, "end": 78}]}}, "schema": []}
{"input": "Pulmonary embolectomy and lung transplantation are the main indications for the use of heart-lung-machine.", "output": {"entities": {}}, "schema": []}
{"input": "The NAUSICAA system gives a good knowledge of LET spectra for the first time in space dosimetry.", "output": {"entities": {}}, "schema": []}
{"input": "In order to quantify these effects, tests were conducted in the NASA MSFC Neutral Buoyancy Simulator, in the NASA KC-135 in parabolic flight, and in space with the EASE program during the Shuttle Atlantis mission 61-B.", "output": {"entities": {}}, "schema": []}
{"input": "This article comparatively evaluates five Generic Systems that describe the basic alternatives to composting facility design and control.", "output": {"entities": {}}, "schema": []}
{"input": "Different thermoluminescent detectors (TLD) have been used to measure the contribution of the low linear energy transfer component (LET < 10 keV/micrometer) and plastic nuclear track detectors (PNTD) for the high linear energy tranfer (LET) component.", "output": {"entities": {}}, "schema": []}
{"input": "Responses of TLD Mg2SiO4: Tb and radiophotoluminescent glass to heavy charged particles and space radiation.", "output": {"entities": {}}, "schema": []}
{"input": "The absorbed dose was measured by combination of two integrating detectors: thermo-luminescent dosemeter of Mg2SiO4: Tb (TDMS) and plastic nuclear track detector (PNTD).", "output": {"entities": {}}, "schema": []}
{"input": "Thus, while the folds of all Myb domains resemble each other closely, the function of each Myb domain depends on the amino acid residues that are located on the surface of each protein.", "output": {"entities": {"gene": [{"text": "Myb domains", "start": 29, "end": 40}, {"text": "Myb domain", "start": 91, "end": 101}]}}, "schema": []}
{"input": "METHODS: Experiments testing the new catheter and comparing it to the existing catheter included: (1) measurement of the laser output beam sizes and divergences; (2) evaluation of particulate matter generation during ablation of atherosclerotic tissue; (3) measurement of ablation hole sizes and tissue penetration rates; (4) histopathologic examination of laser-induced in vivo vessel wall injury.", "output": {"entities": {}}, "schema": []}
{"input": "Overexpression of RORgamma has been shown to inhibit T cell receptor-mediated apoptosis in T cell hybridomas and to repress the induction of Fas-ligand and interleukin 2.", "output": {"entities": {"gene": [{"text": "RORgamma", "start": 18, "end": 26}, {"text": "T cell receptor", "start": 53, "end": 68}, {"text": "Fas-ligand", "start": 141, "end": 151}, {"text": "interleukin 2", "start": 156, "end": 169}]}}, "schema": []}
{"input": "Once ICP reaches critical values (> 30 mm Hg) herniation occurs, usually within 2 to 5 days.", "output": {"entities": {}}, "schema": []}
{"input": "Other therapies are also available, including hypertonic saline solution, THAM (Tris-hydroxy-methyl-aminomethane) buffer, and high-dose barbiturates.", "output": {"entities": {}}, "schema": []}
{"input": "CYP2C19 genotype was determined by the polymerase chain reaction-restriction fragment length polymorphism method.", "output": {"entities": {"gene": [{"text": "CYP2C19 genotype", "start": 0, "end": 16}]}}, "schema": []}
{"input": "The results indicate that a more differentiated diagnosis of the molar relationship will allow for a more causally directed correction of Class II molar relationship.", "output": {"entities": {}}, "schema": []}
{"input": "Similar data were also obtained when either dominant negative EGFR-CD533 or dominant negative Ras N17 were used to block MAPK activation.", "output": {"entities": {"gene": [{"text": "EGFR", "start": 62, "end": 66}, {"text": "CD533", "start": 67, "end": 72}, {"text": "dominant negative Ras N17", "start": 76, "end": 101}, {"text": "MAPK", "start": 121, "end": 125}]}}, "schema": []}
{"input": "These analyses re-open the question whether all the CesA genes encode cellulose synthases or whether some of the sub-class members may encode other non-cellulosic (1--> 4) beta-glycan synthases in plants.", "output": {"entities": {"gene": [{"text": "CesA genes", "start": 52, "end": 62}, {"text": "cellulose synthases", "start": 70, "end": 89}, {"text": "non-cellulosic (1--> 4) beta-glycan synthases", "start": 148, "end": 193}]}}, "schema": []}
{"input": "The mutation experiments showed that the most critical sequence for the repression of PTH was 5'-GGGGGAGGGGAG-3' (+ 1 to + 12) of PTHSR.", "output": {"entities": {"gene": [{"text": "PTH", "start": 86, "end": 89}, {"text": "PTHSR", "start": 130, "end": 135}]}}, "schema": []}
{"input": "Cardiac output at anaerobic threshold (COAT) < or = 7. 3 L/min was the best cutoff value for identifying multivessel coronary artery disease (relative risk, 3. 1).", "output": {"entities": {}}, "schema": []}
{"input": "Experience with xylene-free sections since 1995 at the Vrinnevi Hospital is favorable.", "output": {"entities": {}}, "schema": []}
{"input": "A randomized mix of 180 sections (10 samples x 3 tissues x 3 stains x 2) gave 90 matched pairs.", "output": {"entities": {}}, "schema": []}
{"input": "Interestingly, the CYP71D20-encoded enzyme activity was capable of converting both 5-epi-aristolochene and 1-deoxycapsidiol to capsidiol in vitro, consistent with the notion that this P450 enzyme catalyzes both hydroxylations of its hydrocarbon substrate.", "output": {"entities": {"gene": [{"text": "CYP71D20-encoded enzyme", "start": 19, "end": 42}, {"text": "P450 enzyme", "start": 184, "end": 195}]}}, "schema": []}
{"input": "In conclusion, NF-Y and Sp1 binding sites play a decisive role in the basal expression of the rat mrp2 gene, while the human MRP2 gene is regulated differently.", "output": {"entities": {"gene": [{"text": "NF-Y", "start": 15, "end": 19}, {"text": "Sp1", "start": 24, "end": 27}, {"text": "rat mrp2 gene", "start": 94, "end": 107}, {"text": "human MRP2 gene", "start": 119, "end": 134}]}}, "schema": []}
{"input": "Transcriptional regulation of the estrogen-inducible pS2 breast cancer marker gene by the ERR family of orphan nuclear receptors.", "output": {"entities": {"gene": [{"text": "pS2 breast cancer marker gene", "start": 53, "end": 82}, {"text": "ERR family", "start": 90, "end": 100}, {"text": "orphan nuclear receptors", "start": 104, "end": 128}]}}, "schema": []}
{"input": "NB-506 completely inhibits the capacity of topoisomerase I to phosphorylate, in vitro, the human splicing factor 2/alternative splicing factor (SF2/ASF).", "output": {"entities": {"gene": [{"text": "topoisomerase I", "start": 43, "end": 58}, {"text": "human splicing factor 2", "start": 91, "end": 114}, {"text": "alternative splicing factor", "start": 115, "end": 142}, {"text": "SF2", "start": 144, "end": 147}, {"text": "ASF", "start": 148, "end": 151}]}}, "schema": []}
{"input": "However, during our work with a replication-deficient virus expressing the ASF/SF2 splicing factor from a progesterone antagonist-inducible gene cassette, we discovered that ASF/SF2 was expressed at a significant level in the 293 producer cell line, even in the absence of inducer.", "output": {"entities": {"gene": [{"text": "ASF", "start": 75, "end": 78}, {"text": "SF2", "start": 79, "end": 82}, {"text": "ASF", "start": 174, "end": 177}, {"text": "SF2", "start": 178, "end": 181}]}}, "schema": []}
{"input": "DNA binding assays confirmed the interference of p30 (II) with the assembly of CREB-Tax-p300/CBP multiprotein complexes on 21-bp repeat oligonucleotides in vitro.", "output": {"entities": {"gene": [{"text": "p30 (II)", "start": 49, "end": 57}, {"text": "CREB", "start": 79, "end": 83}, {"text": "Tax", "start": 84, "end": 87}, {"text": "p300", "start": 88, "end": 92}, {"text": "CBP", "start": 93, "end": 96}]}}, "schema": []}
{"input": "Using the presented categorical structure as domain model a prototype DSS for dipslide urine cultures has been developed.", "output": {"entities": {}}, "schema": []}
{"input": "DNA recognition by F factor TraI36: highly sequence-specific binding of single-stranded DNA.", "output": {"entities": {"gene": [{"text": "F factor TraI36", "start": 19, "end": 34}]}}, "schema": []}
{"input": "E47 protein levels remain high until the double positive developmental stage, at which point they drop to relatively moderate levels, and are further downregulated upon transition to the single positive stage.", "output": {"entities": {"gene": [{"text": "E47 protein", "start": 0, "end": 11}]}}, "schema": []}
{"input": "The dual specificity kinases mitogen-activated protein kinase (MAPK) kinase (MKK) 7 and MKK4 are the only molecules known to directly activate the stress kinases stress-activated protein kinases (SAPKs)/c-Jun N-terminal kinases (JNKs) in response to environmental or mitogenic stimuli.", "output": {"entities": {"gene": [{"text": "mitogen-activated protein kinase (MAPK) kinase (MKK) 7", "start": 29, "end": 83}, {"text": "MKK4", "start": 88, "end": 92}, {"text": "stress-activated protein kinases", "start": 162, "end": 194}, {"text": "SAPKs", "start": 196, "end": 201}, {"text": "c-Jun N-terminal kinases", "start": 203, "end": 227}, {"text": "JNKs", "start": 229, "end": 233}]}}, "schema": []}
{"input": "SAPK/JNK activation was completely abolished in the absence of MKK7, even though expression of MKK4 was strongly upregulated in mkk7 (-/-) mast cell lines, and phosphorylation of MKK4 occurred normally in response to multiple stress stimuli.", "output": {"entities": {"gene": [{"text": "SAPK", "start": 0, "end": 4}, {"text": "JNK", "start": 5, "end": 8}, {"text": "MKK7", "start": 63, "end": 67}, {"text": "MKK4", "start": 95, "end": 99}, {"text": "mkk7 (-/-)", "start": 128, "end": 138}, {"text": "MKK4", "start": 179, "end": 183}]}}, "schema": []}
{"input": "Thus, MKK7 is an essential and specific regulator of stress-induced SAPK/JNK activation in mast cells and MKK7 negatively regulates growth factor and antigen receptor-driven proliferation in hematopoietic cells.", "output": {"entities": {"gene": [{"text": "MKK7", "start": 6, "end": 10}, {"text": "SAPK", "start": 68, "end": 72}, {"text": "JNK", "start": 73, "end": 76}, {"text": "MKK7", "start": 106, "end": 110}]}}, "schema": []}
{"input": "When mixed with aqueous solutions of TMT-55, aqueous solutions of either reagent-grade zinc, cadmium, or lead salts precipitate crystalline \" Zn-TMT \", amorphous or crystalline \" Cd-TMT \" or amorphous \" Pb-TMT \" (M3 [S3C3N3] 2. nH2O, where M = Cd2 +, Pb2 +, and Zn2 + and n > or = 0) that may eventually crystallize if stored in air.", "output": {"entities": {}}, "schema": []}
{"input": "Many of the important genes associated with G1 regulation have been shown to play a key role in proliferation, differentiation and oncogenic transformation and programmed cell death (apoptosis).", "output": {"entities": {}}, "schema": []}
{"input": "These results indicate the presence of TATA-unified transcription systems in contemporary eukaryotes and provide insight into the residual need for TBP by all three Pols in other eukaryotes despite a lack of TATA elements in their promoters.", "output": {"entities": {"gene": [{"text": "TBP", "start": 148, "end": 151}, {"text": "Pols", "start": 165, "end": 169}]}}, "schema": []}
{"input": "Thus, through a change in conformation upon repair of the 6RG lesion, MGMT switches from a DNA repair factor to a transcription regulator (R-MGMT), enabling the cell to sense as well as respond to mutagens.", "output": {"entities": {"gene": [{"text": "MGMT", "start": 70, "end": 74}, {"text": "R-MGMT", "start": 139, "end": 145}]}}, "schema": []}
{"input": "A split motor domain in a cytoplasmic dynein.", "output": {"entities": {"gene": [{"text": "cytoplasmic dynein", "start": 26, "end": 44}]}}, "schema": []}
{"input": "In hypertensive nephrosclerosis, therapy containing an ACEI alone or in combination significantly reduces the incidence of renal events.", "output": {"entities": {}}, "schema": []}
{"input": "Body weight reduction increases insulin sensitivity and improves both blood glucose and blood pressure control.", "output": {"entities": {"gene": [{"text": "insulin", "start": 32, "end": 39}]}}, "schema": []}
{"input": "Here we suggest that uvrA and the nucleotide excision repair pathway are involved in the repair of acid-induced DNA damage and are associated with successful adaptation of S. mutans to low pH.", "output": {"entities": {"gene": [{"text": "uvrA", "start": 21, "end": 25}]}}, "schema": []}
{"input": "The best regression model for predicting changes in the WCXR included time to first positive culture and antibody titer for Pa elastase.", "output": {"entities": {"gene": [{"text": "Pa elastase", "start": 124, "end": 135}]}}, "schema": []}
{"input": "Temperature measurement in microfluidic systems using a temperature-dependent fluorescent dye.", "output": {"entities": {}}, "schema": []}
{"input": "APC-resistance was determined with a functional method with high sensitivity and specificity for the factor V Leiden mutation.", "output": {"entities": {"gene": [{"text": "APC", "start": 0, "end": 3}, {"text": "factor V Leiden mutation", "start": 101, "end": 125}]}}, "schema": []}
{"input": "Zarix expected patient enrollment in Canadian clinical sites to begin in Spring 2001 [397955], [405928].", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: The subjects in the augmented feedback group significantly reduced their peak vertical ground reaction force in both post-test conditions (2-minute post-test reduction, 0. 85 +/-0. 62; 1-week post-test reduction, 0. 74 +/-0. 58) as compared to the sensory, control I, and control II feedback groups.", "output": {"entities": {}}, "schema": []}
{"input": "Four casein kinase I isoforms are differentially partitioned between nucleus and cytoplasm.", "output": {"entities": {"gene": [{"text": "casein kinase I isoforms", "start": 5, "end": 29}]}}, "schema": []}
{"input": "Use of a dual-pulse lithotripter to generate a localized and intensified cavitation field.", "output": {"entities": {}}, "schema": []}
{"input": "When the blood clot is formed in the vitreous cavity, intravitreal injection of t-PA can convert plasminogen to plasmin and remove the clot.", "output": {"entities": {"gene": [{"text": "t-PA", "start": 80, "end": 84}, {"text": "plasminogen", "start": 97, "end": 108}, {"text": "plasmin", "start": 112, "end": 119}]}}, "schema": []}
{"input": "Management of postvitrectomy diabetic vitreous hemorrhage with tissue plasminogen activator (t-PA) and volume homeostatic fluid-fluid exchanger.", "output": {"entities": {"gene": [{"text": "tissue plasminogen activator", "start": 63, "end": 91}, {"text": "t-PA", "start": 93, "end": 97}]}}, "schema": []}
{"input": "Effect of heat treatments on the meltability of cheeses.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: Sixty per cent of African Americans exposed in 26 community outbreaks were TST positive compared to only 40% of whites following comparable exposures.", "output": {"entities": {}}, "schema": []}
{"input": "The mean waiting time to receive the pancreas transplant was 244 days for SPK and 167 days for PAK recipients (P = 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "Patients with antibody peaks, defined as fivefold or higher increase in antibody titer compared to the lowest antibody titer over the course of GBS, had higher disability scores during the first two weeks of GBS and a worse clinical outcome (anti-GM1 IgG and anti-GD1a IgM antibody peaks) and axonal damage (anti-GD1a IgM antibody peaks), compared to patients without peak antibody titers.", "output": {"entities": {"gene": [{"text": "anti-GM1 IgG", "start": 242, "end": 254}, {"text": "anti-GD1a IgM antibody", "start": 259, "end": 281}, {"text": "anti-GD1a IgM antibody", "start": 308, "end": 330}]}}, "schema": []}
{"input": "Following baseline clinical examination and initial periodontal therapy, 32 patients received mucogingival surgery with free gingival grafts for treatment of insufficient attached gingiva.", "output": {"entities": {}}, "schema": []}
{"input": "However, patients with isolated office hypertension had fewer previous cardiovascular complications.", "output": {"entities": {}}, "schema": []}
{"input": "In the TVD-patients decreases in skin blood flow were similar compared with the healthy controls.", "output": {"entities": {}}, "schema": []}
{"input": "2: The dynamic moduli of microcrystalline cellulose.", "output": {"entities": {}}, "schema": []}
{"input": "These findings suggest that an intracellular WT-1/HSAL2 pathway may play a role in development and hematopoiesis.", "output": {"entities": {"gene": [{"text": "WT-1", "start": 45, "end": 49}, {"text": "HSAL2", "start": 50, "end": 55}]}}, "schema": []}
{"input": "Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation.", "output": {"entities": {"gene": [{"text": "Stat3", "start": 30, "end": 35}]}}, "schema": []}
{"input": "Plane wave geometry is impractical for clinical use but the results of this work encouraged us to further develop the P3 approximation for a spherical geometry, described in this paper.", "output": {"entities": {}}, "schema": []}
{"input": "The diagnosis of HCV arthritis in patients with positive rheumatoid factor and chronic inflammatory polyarthritis may be difficult.", "output": {"entities": {"gene": [{"text": "rheumatoid factor", "start": 57, "end": 74}]}}, "schema": []}
{"input": "METHODS: We retrospectively selected 13 TFCD patients who underwent surgery for intractable epilepsy with the aim of removing the magnetic resonance (MR)-detectable lesion and/or the epileptogenic zone defined by stereoelectroencephalographic recordings.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: At latest examination, mean UPDRS II and III scores had improved by 30% (on stimulation, off therapy) with mean 50% reduction in daily off time.", "output": {"entities": {}}, "schema": []}
{"input": "In Exp.", "output": {"entities": {}}, "schema": []}
{"input": "Several distinct apoptotic stimuli induce the expression and caspase-dependent cleavage of hTAF (II) 80 delta. hTAF (II) 80 delta, unlike hTAF (II) 80, forms a TFIID-like complex lacking hTAF (II) 31.", "output": {"entities": {"gene": [{"text": "caspase", "start": 61, "end": 68}, {"text": "hTAF (II) 80 delta", "start": 91, "end": 109}, {"text": "hTAF (II) 80 delta", "start": 111, "end": 129}, {"text": "hTAF (II) 80", "start": 138, "end": 150}, {"text": "TFIID-like complex", "start": 160, "end": 178}, {"text": "hTAF (II) 31", "start": 187, "end": 199}]}}, "schema": []}
{"input": "Endovascular aneurysm repair with the AneuRx stent-graft is safe, but is it effective?", "output": {"entities": {}}, "schema": []}
{"input": "Chronic nutritional diseases of infectious origin: an assessment of a nascent field.", "output": {"entities": {}}, "schema": []}
{"input": "Drug interactions have been found with drugs that compete for the same CYP450 isoenzymes as statins.", "output": {"entities": {"gene": [{"text": "CYP450 isoenzymes", "start": 71, "end": 88}]}}, "schema": []}
{"input": "METHODS: We studied the clinical benefit of depth-dependent RR, nonuniform AC using a scanning line source, and scatter correction (photon energy recovery [PER]) compared with filtered backprojection alone.", "output": {"entities": {}}, "schema": []}
{"input": "Because of differences in patient characteristics, control measurements were obtained from normal muscle in all patients.", "output": {"entities": {}}, "schema": []}
{"input": "However, the abi1-1 gene product has no effect on the ABA suppression of a GA-responsive alpha-amylase gene.", "output": {"entities": {"gene": [{"text": "abi1-1 gene product", "start": 13, "end": 32}, {"text": "alpha-amylase gene", "start": 89, "end": 107}]}}, "schema": []}
{"input": "In children unable to perform forced expiratory maneuvers (n = 25), FOT, contrary to the interrupter technique, clearly identified a subgroup of young children with high resistance values at baseline, which returned to normal after bronchodilation.", "output": {"entities": {}}, "schema": []}
{"input": "In budding yeast, this latter checkpoint response involves the proteins Mad1, 2, 3, Bub1 and Bub3, whose vertebrate counterparts localize to unattached kinetochores.", "output": {"entities": {"gene": [{"text": "Mad1, 2, 3", "start": 72, "end": 82}, {"text": "Bub1", "start": 84, "end": 88}, {"text": "Bub3", "start": 93, "end": 97}]}}, "schema": []}
{"input": "HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis.", "output": {"entities": {}}, "schema": []}
{"input": "However, the beta5L splice variant was found only in the retina.", "output": {"entities": {}}, "schema": []}
{"input": "PROCEDURE: Cannulas were surgically positioned in the abomasal body and pyloric antrum of each calf.", "output": {"entities": {}}, "schema": []}
{"input": "METHODS: Humphrey Field Analyzer model 630 (HFA I, program 30-2 with a rectangular 6 degrees x 6 degrees grid) was used as the conventional perimetric method.", "output": {"entities": {}}, "schema": []}
{"input": "Transforming growth factor-beta (TGF-beta) induced growth arrest of cells involves regulation of the activities of both D-and E-type cyclin kinase complexes thought to be mediated primarily by the regulation of p15 (Ink4b) and p27 (Kip1) cyclin kinase inhibitors.", "output": {"entities": {"gene": [{"text": "Transforming growth factor-beta", "start": 0, "end": 31}, {"text": "TGF-beta", "start": 33, "end": 41}, {"text": "D-and E-type cyclin kinase complexes", "start": 120, "end": 156}, {"text": "p15", "start": 211, "end": 214}, {"text": "Ink4b", "start": 216, "end": 221}, {"text": "p27", "start": 227, "end": 230}, {"text": "Kip1", "start": 232, "end": 236}]}}, "schema": []}
{"input": "Alignment of different cDNAs of the NR5A2 (hB1F) gene with the genomic sequence facilitated the delineation of its structural organization, which spans over 150 kb and consists of eight exons interrupted by seven introns.", "output": {"entities": {"gene": [{"text": "NR5A2", "start": 36, "end": 41}, {"text": "hB1F", "start": 43, "end": 47}]}}, "schema": []}
{"input": "The genomic structure of the human SPEC1 gene reveals complex splicing and close promoter proximity to the AF1q translocation gene.", "output": {"entities": {"gene": [{"text": "human SPEC1 gene", "start": 29, "end": 45}, {"text": "AF1q translocation gene", "start": 107, "end": 130}]}}, "schema": []}
{"input": "Hp positive relatives of gastric cancer had a markedly higher prevalence of atrophy than those with Hp negativity without cancer relatives (29 vs.", "output": {"entities": {}}, "schema": []}
{"input": "Peripheral metabolism of androgens takes place in various areas within the pilosebaceous unit, as indicated by local differences in the activities of aromatase, 5alpha-reductase as well as of the presence of the androgen receptors.", "output": {"entities": {"gene": [{"text": "aromatase", "start": 150, "end": 159}, {"text": "5alpha-reductase", "start": 161, "end": 177}, {"text": "androgen receptors", "start": 212, "end": 230}]}}, "schema": []}
{"input": "The uptake of fluorine-18 fluorodeoxyglucose (F-18 FDG) by a malignant tumor depends on the blood glucose level.", "output": {"entities": {}}, "schema": []}
{"input": "This analysis supports the use of fluticasone propionate 88 microg twice daily as first-line treatment in patients with persistent asthma previously treated with short-acting beta2-agonist alone.", "output": {"entities": {"gene": [{"text": "beta2", "start": 175, "end": 180}]}}, "schema": []}
{"input": "By using space-discrete/continuous metapopulation dynamic models and computer simulations, we show that there can be two principally different regimes of metapopulation dynamics.", "output": {"entities": {}}, "schema": []}
{"input": "Eight CAD patients who were matched to the treated patients for age (+/-3 years), baseline low density lipoprotein (+/-5 mg/dL), and triglycerides (+/-50 mg/dL) but who had never been treated with lipid-lowering drugs were selected as controls.", "output": {"entities": {"gene": [{"text": "low density lipoprotein", "start": 91, "end": 114}]}}, "schema": []}
{"input": "RESULTS: A novel gene was cloned.", "output": {"entities": {}}, "schema": []}
{"input": "The moduli of elasticity of the gray and white matter were 3. 4 +/-1. 4 kPa (mean +/-standard deviation) and 3. 4 +/-0. 9 kPa in the axial section, 3 +/-0. 3 kPa and 3. 5 +/-0. 5 kPa in the frontal section, and 3. 5 +/-0. 9 kPa and 2. 8 +/-0. 4 kPa in the sagittal section, respectively.", "output": {"entities": {}}, "schema": []}
{"input": "Direct current polarography and differential pulse polarographic methods have been developed for the qualitative as well as quantitative analysis of vitamin B1, B2 and B6.", "output": {"entities": {}}, "schema": []}
{"input": "Against gram-positive organisms, E-4767 and E-5065 were, in general, eight-and fourfold more active than tosufloxacin, which is the most potent of the reference compounds.", "output": {"entities": {}}, "schema": []}
{"input": "However, most produced significant alteration of small intestinal permeability.", "output": {"entities": {}}, "schema": []}
{"input": "These included HNF-3 beta, HFH-1, HFH-2, HFH-3, C/EBP, and C/EBP beta, all of which are consistent with the tissue-specific expression profiles of the gene.", "output": {"entities": {"gene": [{"text": "HNF-3 beta", "start": 15, "end": 25}, {"text": "HFH-1", "start": 27, "end": 32}, {"text": "HFH-2", "start": 34, "end": 39}, {"text": "HFH-3", "start": 41, "end": 46}, {"text": "C/EBP", "start": 48, "end": 53}, {"text": "C/EBP beta", "start": 59, "end": 69}]}}, "schema": []}
{"input": "Managing vertigo and vertigo syndromes in the elderly", "output": {"entities": {}}, "schema": []}
{"input": "The MABP and MCBFV signals were bandpass filtered in the very low-frequency range (VLF, 0. 015-0. 07 Hz), low-frequency range (LF, 0. 07-0. 15 Hz) and high-frequency range (HF, 0. 15-0. 40 Hz) before applying CCF for the purpose of studying the effect of different bandwidths on the resulting mean CCFs.", "output": {"entities": {}}, "schema": []}
{"input": "Hepatitis B and C seroprevalence rates among high-risk adolescents are lower in El Paso than in other similar US populations, presenting an ideal climate for prevention programs.", "output": {"entities": {}}, "schema": []}
{"input": "A twelfth insertion disrupts two genes, Nrk, a \" neurospecific \" receptor tyrosine kinase, and Tpp, which encodes a neuropeptidase.", "output": {"entities": {"gene": [{"text": "Nrk", "start": 40, "end": 43}, {"text": "\" neurospecific \" receptor tyrosine kinase", "start": 47, "end": 89}, {"text": "Tpp", "start": 95, "end": 98}, {"text": "neuropeptidase", "start": 116, "end": 130}]}}, "schema": []}
{"input": "Not Available", "output": {"entities": {}}, "schema": []}
{"input": "This unique work needs to be edited critically and afterwards translated into Urdu and other languages for the benefit of the present day students and scholars.", "output": {"entities": {}}, "schema": []}
{"input": "Comparison of German language versions of the QWB-SA and SF-36 evaluating outcomes for patients with prostate disease.", "output": {"entities": {}}, "schema": []}
{"input": "Disciplinary action for DNA violation.", "output": {"entities": {}}, "schema": []}
{"input": "Epithelial cytotoxicity of combined antibiotics was additive, with no evidence of competition or synergism.", "output": {"entities": {}}, "schema": []}
{"input": "Pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-alpha), produced from adipose tissues in obese subjects, is known to play a predominant role in inducing insulin resistance.", "output": {"entities": {"gene": [{"text": "tumor necrosis factor-alpha", "start": 27, "end": 54}, {"text": "TNF-alpha", "start": 56, "end": 65}, {"text": "insulin", "start": 165, "end": 172}]}}, "schema": []}
{"input": "The most important finding, however, was that IMT values were related with 24 h SBP or PP standard deviation (P < 0. 001), a measure of overall SBP or PP variability.", "output": {"entities": {}}, "schema": []}
{"input": "The difference between the patients and the controls was statistically significant (p = 0. 03).", "output": {"entities": {}}, "schema": []}
{"input": "The effect of crude oil spillage on growth, productivity and nutrient uptake of maize (Zea mays L.) was assessed in a pot experiment using an Evwreni manifold sample of a petroleum development company, which had a specific gravity of 0. 8778.", "output": {"entities": {}}, "schema": []}
{"input": "NO metabolites were determined by the measurement of nitrate/nitrite (NOx, micromol/mmol creatinine) and cyclic guanosine monophosphate (cGMP, nmol/mmol creatinine) in plasma and urine.", "output": {"entities": {}}, "schema": []}
{"input": "In the base-case analysis, total direct costs per patient were $728 for zoledronic acid and $776 for pamidronate.", "output": {"entities": {}}, "schema": []}
{"input": "The diet of migrants showed both positive (macronutrients) and negative (micronutrients) differences with the general Dutch diet.", "output": {"entities": {}}, "schema": []}
{"input": "C. elegans embryogenesis begins with a stereotyped sequence of asymmetric cell divisions that are largely responsible for establishing the nematode body plan.", "output": {"entities": {}}, "schema": []}
{"input": "Finally, a chromogenic method was used, based on thrombin inhibition and the substrate S-2238.", "output": {"entities": {"gene": [{"text": "thrombin", "start": 49, "end": 57}]}}, "schema": []}
{"input": "[Diabetologia (2001) 44 [Suppl 3]: B37-B44]", "output": {"entities": {}}, "schema": []}
{"input": "The 5' flanking sequence of the 3B gene is extremely A + T rich but contains five G/C rich stretches, each approximately 7bp long, which have strong sequence similarity to the G boxes found upstream of other developmentally regulated Dictyostelium genes.", "output": {"entities": {"gene": [{"text": "3B gene", "start": 32, "end": 39}]}}, "schema": []}
{"input": "Considering that the reactor is thoroughly mixed during each discharge and that LD50 = 0. 9 values are nearly independent of E. coli concentrations in the range of 2 x 10 (3) < or = E coli/cfu mL (-1) < or = 3 x 10 (6), we ascribe the nonexponential Pn decay of single-strain E. coli colonies to a shielding phenomenon where inactive cells protect the successively smaller numbers of viable cells in the EHD.", "output": {"entities": {}}, "schema": []}
{"input": "In the long term, questions still remain about whether pre-dialysis rHu EPO either speeds up or delays the onset of dialysis.", "output": {"entities": {"gene": [{"text": "rHu EPO", "start": 68, "end": 75}]}}, "schema": []}
{"input": "METHODS: This retrospective review comprised 2711 eyes that had LASIK between September 1996 and September 1999.", "output": {"entities": {}}, "schema": []}
{"input": "No ISREs could be identified in the mouse promoter.", "output": {"entities": {"gene": [{"text": "ISREs", "start": 3, "end": 8}]}}, "schema": []}
{"input": "BACKGROUND: Ischemic heart disease is the primary cause of morbidity and mortality among diabetics, especially those who became ill at a young age.", "output": {"entities": {}}, "schema": []}
{"input": "A 38-year-old woman with ulcerative colitis subsequently developed sarcoidosis.", "output": {"entities": {}}, "schema": []}
{"input": "Cholesteryl ester transfer protein and atherosclerosis in Japanese subjects: a study based on coronary angiography.", "output": {"entities": {"gene": [{"text": "Cholesteryl ester transfer protein", "start": 0, "end": 34}]}}, "schema": []}
{"input": "Electrophoretic mobility shift assays and coimmunoprecipitation studies suggest that homo-and heterodimerization occurs between cKrox family members.", "output": {"entities": {"gene": [{"text": "cKrox family members", "start": 128, "end": 148}]}}, "schema": []}
{"input": "The hcKrox gene family regulates multiple extracellular matrix genes.", "output": {"entities": {"gene": [{"text": "hcKrox", "start": 4, "end": 10}]}}, "schema": []}
{"input": "A review of the literature identified 8 comprehensive clinical studies, all of which failed to document any relationship between NF1 and intracranial aneurysms.", "output": {"entities": {"gene": [{"text": "NF1", "start": 129, "end": 132}]}}, "schema": []}
{"input": "These utilisation data imply annual drug costs in the range of $US 480, 000 to $US 3, 600, 000 for TNF antagonists for RA per 1 million population.", "output": {"entities": {"gene": [{"text": "TNF", "start": 99, "end": 102}]}}, "schema": []}
{"input": "This study investigated whether boron would enhance the ability of 17beta-estradiol (E2) or parathyroid hormone (PTH) to improve bone quality in ovariectomized OVX rats.", "output": {"entities": {"gene": [{"text": "parathyroid hormone", "start": 92, "end": 111}, {"text": "PTH", "start": 113, "end": 116}]}}, "schema": []}
{"input": "We found in the control subjects rCBF increases in regions associated with the meso-striatal and meso-corticolimbic circuits in response to both monetary reward and nonmonetary reinforcement.", "output": {"entities": {}}, "schema": []}
{"input": "Doxorubicin (DOX) is commonly used for the treatment of hematological and solid tumors.", "output": {"entities": {}}, "schema": []}
{"input": "The event rate in patients with chronic Irr-rMFP or Un-nrMFP was markedly higher than it was in those with Rev-rMFP or Sta-nrMFP.", "output": {"entities": {}}, "schema": []}
{"input": "Subtraction hybridization identified melanoma differentiation associated gene-7 (mda-7), as a gene induced during these physiological changes in human melanoma cells.", "output": {"entities": {"gene": [{"text": "melanoma differentiation associated gene-7", "start": 37, "end": 79}, {"text": "mda-7", "start": 81, "end": 86}]}}, "schema": []}
{"input": "Therefore, vitamin D3 analogues have a substantial antipsoriatic effect.", "output": {"entities": {}}, "schema": []}
{"input": "Hydrocoele is common in men in Wuchereria bancrofti-endemic areas, the treatment for which is currently surgical intervention.", "output": {"entities": {}}, "schema": []}
{"input": "Growth hormone and insulin-like growth factor I receptors in the temporomandibular joint of the rat.", "output": {"entities": {"gene": [{"text": "Growth hormone", "start": 0, "end": 14}, {"text": "insulin-like growth factor I receptors", "start": 19, "end": 57}]}}, "schema": []}
{"input": "In addition to that, she received hepatic intra-arterial infusion of levoforinate (l-LV) 250 mg and 5-fluorouracil (5-FU) 500 mg for combined multiple hepatic metastases starting on postoperative day 14, and these medications were administered over 48 hours once weekly by infuser pump.", "output": {"entities": {}}, "schema": []}
{"input": "The astronaut crew operates the payload and documents its operation.", "output": {"entities": {}}, "schema": []}
{"input": "For these patients the introduction of a separate category \" extended oligoarthritis at onset \" should be considered to establish comparable patient groups.", "output": {"entities": {}}, "schema": []}
{"input": "Phase II trial of the anti-G (D2) monoclonal antibody 3F8 and granulocyte-macrophage colony-stimulating factor for neuroblastoma.", "output": {"entities": {"gene": [{"text": "anti-G (D2) monoclonal antibody 3F8", "start": 22, "end": 57}, {"text": "granulocyte-macrophage colony-stimulating factor", "start": 62, "end": 110}]}}, "schema": []}
{"input": "Hepatitis A infected food handler at an Edmonton, Alberta retail food facility: public health protection strategies.", "output": {"entities": {}}, "schema": []}
{"input": "Hydrogels for tissue engineering.", "output": {"entities": {}}, "schema": []}
{"input": "Eliminating any subset of ASCUS reduces the ASCUS/SIL ratio but also significantly diminishes the sensitivity of the Papanicolaou test.", "output": {"entities": {}}, "schema": []}
{"input": "Eliminating any subset of ASCUS reduces the ASCUS/SIL ratio but also significantly diminishes the sensitivity of the Papanicolaou test.", "output": {"entities": {}}, "schema": []}
{"input": "Two nuclear medicine physicians blinded to the surgical findings interpreted all available images and various Tc-99m MIBI image combinations at 15 minutes alone; 15 minutes and 2 hours, 15 minutes and 4 hours; and 15 minutes and 2 and 4 hours each with and without correlative pertechnetate thyroid imaging.", "output": {"entities": {}}, "schema": []}
{"input": "Between 1967 and 1994, 495 patients underwent surgery for primary PTC at the Department of Surgery, Helsinki University Central Hospital.", "output": {"entities": {}}, "schema": []}
{"input": "ISS and the acute physiology and chronic health evaluation (APACHE II) calculated on admission.", "output": {"entities": {}}, "schema": []}
{"input": "The procedure is less aggressive and painful than sternotomy.", "output": {"entities": {}}, "schema": []}
{"input": "Paul Monagle addresses the epidemiology of neonatal thrombosis outside of the central nervous system in both arterial and venous locations, and those that occur in utero.", "output": {"entities": {}}, "schema": []}
{"input": "[Clinical and epidemiological characteristics of squamous cell carcinoma of the oral cavity in women] BACKGROUND: Squamous cell carcinoma (SCC) of the oral cavity occurs mainly in the male population.", "output": {"entities": {}}, "schema": []}
{"input": "Regarding gestational risk, 3, 243 drugs used (34%) belonged to category A risk, 1, 923 (22. 6%) to category B, 3, 798 (39. 7%) to category C, 289 (3. 0%) to category D, and 55 (0. 6%) to category X.", "output": {"entities": {}}, "schema": []}
{"input": "The process has been applied to the river reclamation in Yangpu District of Shanghai City, China.", "output": {"entities": {}}, "schema": []}
{"input": "Physical principles in therapeutic apheresis.", "output": {"entities": {}}, "schema": []}
{"input": "Rind et al.' s study' s main conclusions were not supported by the original data.", "output": {"entities": {}}, "schema": []}
{"input": "Of major concern to food processors is the inadvertent cross-contact of food products with allergenic residues, which could result in potentially life-threatening reactions in those with a food allergy.", "output": {"entities": {}}, "schema": []}
{"input": "Lactate accumulation peak was unaffected by supplementation (HMB, 8. 1 +/-1. 1 mM; LEU, 6. 2 +/-0. 8 mM; CON, 7. 5 +/-1. 3 mM).", "output": {"entities": {}}, "schema": []}
{"input": "The increased clearance observed in young infants is in contrast to other opioids.", "output": {"entities": {}}, "schema": []}
{"input": "These results were robust to changes in the baseline assumptions of the model.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSION: The training of novices using MIST-VR yields quantifiable changes in skill that are transferable to a simple real task and are similar to the results achieved with conventional training.", "output": {"entities": {}}, "schema": []}
{"input": "The patients and their families were closely questioned, and full clinical examination included a test for orthostasia.", "output": {"entities": {}}, "schema": []}
{"input": "They have not been previously reported as a reaction to i. v. contrast material.", "output": {"entities": {}}, "schema": []}
{"input": "There was a statistically significant correlation between simultaneous weekly average pollen levels in Philadelphia and in Cherry Hill (Acer, r (p) = 0. 987, Quercus, r (p) = 0. 645, Betula, r (p) = 0. 896, Pinus, r (p) = 0. 732, Cupressaceae, r (p) = 0. 695, Poaceae, r (p) = 0. 950, Ambrosia, r (p) = 0. 903, and Rumex, r (p) = 0. 572, P < 0. 001).", "output": {"entities": {}}, "schema": []}
{"input": "Encouraged by a Dutch study using etidronate/fluoride in corticoid-induced osteoporosis, we performed a pilot study in 33 men with severe established primary osteoporosis giving cyclically etidronate for 14 days followed by fluoride plus calcium/vitamin D for 76 days.", "output": {"entities": {}}, "schema": []}
{"input": "In order to overcome the false positive readings that are possible in sphincter manometry, we proposed to use secretin stimulated endoscopic ultrasound (SSEUS) to measure pancreatic ductal response as an adjunctive method to aid and supplement the diagnosis.", "output": {"entities": {"gene": [{"text": "secretin", "start": 110, "end": 118}]}}, "schema": []}
{"input": "The cut-off percentage positivity value was established using 500 brucellosis-positive and 500 brucellosis-negative serum samples, confirmed with reference to the sample data using the indirect ELISA kit.", "output": {"entities": {}}, "schema": []}
{"input": "An analysis of the dynamics is performed of exactly solvable models for fragile and strong glasses, exploiting the partitioning of the free-energy landscape in inherent structures.", "output": {"entities": {}}, "schema": []}
{"input": "Fifty-six semen samples were included in this study; 18 were subnormal (G1) and 38 were normal (G2) based on World Health Organization criteria, except for morphology, which was evaluated according to strict criteria.", "output": {"entities": {}}, "schema": []}
{"input": "At this timepoint, many leucocytes in the ME and ET mucosa had incorporated BrdU (between 15 and 25% within the subsets).", "output": {"entities": {}}, "schema": []}
{"input": "Their chemical structures were elucidated as 1 alpha, 2 alpha-diacetoxy-8 beta-isobutanoyloxy-9 alpha-benzoyloxy-13-(alpha-methyl) butanoyloxy-4 beta, 6 beta-dihydroxy-beta-dihydroagarofuran (1), 1 alpha, 2 alpha-diacetoxy-8 beta-(beta-furancarbonyloxy)-9 alpha-benzoyloxy-13-isobutanoyloxy-4 beta, 6 beta-dihydroxy-beta-dihydroagarofuran (2) and 1 alpha, 6 beta, 8 alpha, 13-tetraacetoxy-9 alpha-benzoyloxy-2 alpha-hydroxy-beta-dihydroagarofuran (3) mainly by analyses NMR and MS spectral data.", "output": {"entities": {}}, "schema": []}
{"input": "Saunders Company.", "output": {"entities": {}}, "schema": []}
{"input": "Acute stress in 7 rats also increased the mean amount of IL-6 released in the urine by 31. 5% from 775. 9 +/-69. 2 to 1, 021. 1 +/-93. 3 pg./ml.", "output": {"entities": {"gene": [{"text": "IL-6", "start": 57, "end": 61}]}}, "schema": []}
{"input": "Patients with CF and meconium ileus presented a poor nutritional status at diagnosis and a lower survival rate compared to the general CF population.", "output": {"entities": {}}, "schema": []}
{"input": "(Cactaceae) waste matter.", "output": {"entities": {}}, "schema": []}
{"input": "Skin cancers, followed by gastrointestinal tract and male genital system affected mostly older age patients.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSION: MMF (2-3 g/day) is unable to control the signs of mucocutaneous Adamantiades-Behcet' s disease.", "output": {"entities": {}}, "schema": []}
{"input": "In the treatment of opioid naive patients who underwent surgery and received opioids for acute pain, oral ADL 8-2698 (6. 0 mg) improved the management of postoperative ileus (POI) by shortening the time to achieve normal bowel function and, ultimately, hospital stay.", "output": {"entities": {}}, "schema": []}
{"input": "Evidence suggests that PHACES syndrome is not a random association but a true phakomatosis; further studies are awaited to shed light on a possible genetic background.", "output": {"entities": {}}, "schema": []}
{"input": "Moreover, a severe decrease of antithrombin activity became evident during both experiments (eg, in experiment 2 from 95. 6 +/-4. 8 to 59. 2 +/-6. 6%).", "output": {"entities": {"gene": [{"text": "antithrombin", "start": 31, "end": 43}]}}, "schema": []}
{"input": "The Penn State Worry Questionnaire for Children (PSWQ-C) is a 14-item self-report questionnaire that intends to measure the tendency of children to engage in excessive, generalized, and uncontrollable worry (Chorpita et al., Behav.", "output": {"entities": {}}, "schema": []}
{"input": "Described X-ray projection were performed in 70 patients.", "output": {"entities": {}}, "schema": []}
{"input": "Pyrethroid insecticides are widely used in agriculture and private households.", "output": {"entities": {}}, "schema": []}
{"input": "The sorption mechanisms changed from adsorption to partition in the process of repetitious sorption.", "output": {"entities": {}}, "schema": []}
{"input": "Although the spatial and temporal variability of LDF signals evoked by cerebrocortical microflow is in the same range as with other methods and in other organs, LDF cerebrocortical mapping is restricted by the large temporal and spatial heterogeneity of the cerebrocortical vasculature.", "output": {"entities": {}}, "schema": []}
{"input": "The 5-year overall survival (OS) and progression-free survival (PFS) rates were 58. 9% and 55. 4% for arm A and 44. 5% and 41. 3% for arm B (P =. 007 and P =. 02), respectively.", "output": {"entities": {}}, "schema": []}
{"input": "METHODS: P-selectin expression of nonstimulated and ADP-stimulated platelets was flow cytometrically measured before the clopidogrel loading dose and on 3 consecutive days in 52 patients with coronary artery disease: 21 patients in group 1 received 300 mg of clopidogrel after stent implantation and 11 patients in group 2 received the higher 450-mg clopidogrel loading dose followed by a daily dose of 75 mg of clopidogrel for both groups.", "output": {"entities": {"gene": [{"text": "P-selectin", "start": 9, "end": 19}]}}, "schema": []}
{"input": "Traditional surgical exploration was followed by survey with a gamma-detecting probe.", "output": {"entities": {}}, "schema": []}
{"input": "No effect of the intervention on depression scores was found.", "output": {"entities": {}}, "schema": []}
{"input": "IV. combined sclerosis and resorption of the skull base (6 cases, 2 group I lesions and 4 group II lesions).", "output": {"entities": {}}, "schema": []}
{"input": "The quantity of each population (L. bulgaricus, S. thermophilus) was then estimated in the pellet by PyMS, and the data were analysed by artificial neural networks (ANNs).", "output": {"entities": {}}, "schema": []}
{"input": "AF showed a mixed nuclear/cytoplasmic pattern of expression in the epithelial, endothelial, and stromal component of the normal breast and benign lesions, whereas an impressive loss of AF expression was noted in in situ and invasive breast cancer and tumoral stroma.", "output": {"entities": {"gene": [{"text": "AF", "start": 0, "end": 2}, {"text": "AF", "start": 185, "end": 187}]}}, "schema": []}
{"input": "We derive joint probability density distributions for three key uncertain properties of the climate system, using an optimal fingerprinting approach to compare simulations of an intermediate complexity climate model with three distinct diagnostics of recent climate observations.", "output": {"entities": {}}, "schema": []}
{"input": "Frequency of seeing curves were examined for the method most similar to FDT.", "output": {"entities": {}}, "schema": []}
{"input": "Chronic graft-versus-host disease (cGVHD) is a major complication of allogeneic hematopoietic cell transplantation.", "output": {"entities": {}}, "schema": []}
{"input": "Compared to white-on-white (W-W) perimetry, SWAP is limited clinically by: greater variability associated with the estimation of threshold, ocular media absorption, increased examination duration and an additional learning effect.", "output": {"entities": {}}, "schema": []}
{"input": "Preservatives are an important component of ophthalmic preparations, providing antimicrobial activity in the bottle and preventing decomposition of active drug.", "output": {"entities": {}}, "schema": []}
{"input": "Comparative analysis of various techniques of prostatic drainage in patients with chronic obstructive prostatitis] The efficacy of prostatic drainage using transurethral vacuum aspiration (Introl-4 unit) and transrectal pneumovibromassage (PVM-R-01) was compared in 1511 patients with chronic obstructive prostatitis.", "output": {"entities": {}}, "schema": []}
{"input": "Consumption of 4% sucrose was not affected by excitotoxic lesions of the PPTg, but PPTg lesioned rats consumed significantly more 12% and 20% sucrose than sham controls.", "output": {"entities": {}}, "schema": []}
{"input": "Actuarial freedom from ventricular arrhythmias at 4-year follow-up was 74. 1 +/-6. 0% in group A vs.", "output": {"entities": {}}, "schema": []}
{"input": "Mental development is generally normal.", "output": {"entities": {}}, "schema": []}
{"input": "Influence of different methods of chemical disinfection on the physical properties of type IV and V gypsum dies] Several instruments and materials frequently used in prosthodontics--such as stone casts, dental impressions, interocclusal records--are classified, by the dental literature, as vehicles of transmission of infectious diseases to those who handle them.", "output": {"entities": {}}, "schema": []}
{"input": "Vitrectomy and removal of retained lens fragments restores good visual acuity and reduces secondary glaucoma in the majority of patients.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS: The mechanism of MIRI is Qi deficiency and blood stasis in TCM, its treating principles should be promoting Qi and removing the blood stasis.", "output": {"entities": {}}, "schema": []}
{"input": "Effects of activating blood circulation to remove blood stasis on barrier action of gastric wall in chronic atrophic gastritis", "output": {"entities": {}}, "schema": []}
{"input": "Proteomic patterns of nipple aspirate fluids obtained by SELDI-TOF: potential for new biomarkers to aid in the diagnosis of breast cancer.", "output": {"entities": {}}, "schema": []}
{"input": "According to the laboratory results, the application of neural network can solve the problem successfully.", "output": {"entities": {}}, "schema": []}
{"input": "A high-efficiency cross-flow micronebulizer interface for capillary electrophoresis and inductively coupled plasma mass spectrometry.", "output": {"entities": {}}, "schema": []}
{"input": "The experimental results showed that the coagulation-electrooxidation process could efficiently remove the color and the COD from the simulated dye wastewater.", "output": {"entities": {}}, "schema": []}
{"input": "Cyclic loading of bone during normal daily activity leads to the formation of microcracks within the tissue matrix of compact bone.", "output": {"entities": {}}, "schema": []}
{"input": "The weight-bearing surface of the PE head became smoother with time after THA, and the friction coefficient did not differ significantly from that of an unused PE head.", "output": {"entities": {}}, "schema": []}
{"input": "OBJECTIVE: To demonstrate a lack of effect of steady-state concentrations of cilomilast, a new oral phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease, on warfarin-induced anticoagulation.", "output": {"entities": {"gene": [{"text": "phosphodiesterase 4", "start": 100, "end": 119}]}}, "schema": []}
{"input": "Postdocs face hardship across mainland Europe.", "output": {"entities": {}}, "schema": []}
{"input": "The design principle based on a uniform vibration mode is presented.", "output": {"entities": {}}, "schema": []}
{"input": "Dynamic imaging of nuclear wave functions with ultrashort UV laser pulses.", "output": {"entities": {}}, "schema": []}
{"input": "Efficacy and safety of aspirin in the long-term management of atherothrombosis.", "output": {"entities": {}}, "schema": []}
{"input": "The General Practice Research Database (GPRD) is the world' s largest computerized database of anonymized longitudinal patient records from general practice and is a unique public health research tool.", "output": {"entities": {}}, "schema": []}
{"input": "This paper reports the results of a laboratory study on aldicarb and its main metabolites, aldicarb sulfone and aldicarb sulfoxide.", "output": {"entities": {}}, "schema": []}
{"input": "Only one DC cardioversion was required in the HBS group, whereas 2 DC in the CBC group and total 7 DC in the GIK group.", "output": {"entities": {}}, "schema": []}
{"input": "Since August 1994, the ENRP has retained 70. 3 metric tons of TP that otherwise would have entered the Everglades.", "output": {"entities": {}}, "schema": []}
{"input": "It was found that the disappearance of BOD5 and NH3-N could be approximated using first-order kinetics, but the kinetics of TP removal were unclear.", "output": {"entities": {}}, "schema": []}
{"input": "It was found that the disappearance of BOD5 and NH3-N could be approximated using first-order kinetics, but the kinetics of TP removal were unclear.", "output": {"entities": {}}, "schema": []}
{"input": "Losses of dichlofluanid (54%), chlozolinate (22%), and etridiazole (40%), previously reported to occur during ambient processing of apples, were reduced to barely significant levels (10, 17, and 14%, respectively) by cryogenic processing.", "output": {"entities": {}}, "schema": []}
{"input": "The TB incidence in the \" AIRIN \" area, where about 20% TB patients are homeless, shows highest rate of above 1, 000/100, 000.", "output": {"entities": {}}, "schema": []}
{"input": "It is shown that the displacement distribution measured by q-space MRI in both the large displacement (i. e., large r) and the long-wavelength (i. e., small q) limits is the same 3D Gaussian displacement distribution assumed in DT-MRI.", "output": {"entities": {}}, "schema": []}
{"input": "The procedure facilitated the retention of a mandibular molar with a Class III FI in a manner acceptable to both the patient and the clinician.", "output": {"entities": {}}, "schema": []}
{"input": "The results of our ten-fold cross-validation experiments show that, on the average, the system increases the specificity from 0. 19 (0. 35) to 0. 69 (0. 74) at a sensitivity level of 1. 0 (0. 95).", "output": {"entities": {}}, "schema": []}
{"input": "The physical characteristics of these calls vary among species of bat, and variations also exist in the timing and patterns of respiratory muscle recruitment during echolocation.", "output": {"entities": {}}, "schema": []}
{"input": "Clicking on \" Examples and Explanations of APA Form \" provides a help system with examples of the various sections of a review article, journal article that has one experiment, or journal article that has two or more experiments.", "output": {"entities": {}}, "schema": []}
{"input": "The drug packets contained acetyl aspirin, acetaminophen and chloramphenicol.", "output": {"entities": {}}, "schema": []}
{"input": "Karger AG, Basel", "output": {"entities": {}}, "schema": []}
{"input": "AIM: To understand the role of nutritional status in cirrhotic patients without clinical porto-systemic encephalopathy (PSE). METHODS: Fifty-one non-alcoholic patients with cirrhosis without PSE were studied prospectively and compared with 20 healthy volunteers.", "output": {"entities": {}}, "schema": []}
{"input": "MAIN OUTCOME MEASURE (S): Serum levels of FSH, LH, and inhibin A and B.", "output": {"entities": {"gene": [{"text": "FSH", "start": 42, "end": 45}, {"text": "LH", "start": 47, "end": 49}, {"text": "inhibin A and B", "start": 55, "end": 70}]}}, "schema": []}
{"input": "For instance, a total SIP score of an individual patient of 28. 3% (which is taken as an example, being the mean score in the study population) should decrease by at least 9. 26% or approximately 13 items, before any improvement beyond reproducibility noise can be detected.", "output": {"entities": {}}, "schema": []}
{"input": "Group I comprised 5 adult Collies that received at least 400 microg/kg ivermectin p. o. and were presented to the VMTH 3 hours after intoxication.", "output": {"entities": {}}, "schema": []}
{"input": "No increased tumor-related mortality was observed after a mean follow-up of 44 months.", "output": {"entities": {}}, "schema": []}
{"input": "Dissociable effects of lidocaine inactivation of the rostral and caudal basolateral amygdala on the maintenance and reinstatement of cocaine-seeking behavior in rats.", "output": {"entities": {}}, "schema": []}
{"input": "The population studied comprised 4472 men and 5212 women aged 30-74 years, without coronary heart disease, who had CRP measurements in the Third National Health and Nutrition Examination Survey (NHANES III).", "output": {"entities": {"gene": [{"text": "CRP", "start": 115, "end": 118}]}}, "schema": []}
{"input": "Herceptin, which recognizes the HER-2/neu antigen and has similar size (10 nm) to G6-(1B4M-Gd) (256), accumulated and internalized in the WIBC-9 tumors more quickly than in the control MC-5 tumors that progress with normal angiogenesis.", "output": {"entities": {"gene": [{"text": "HER-2", "start": 32, "end": 37}, {"text": "neu", "start": 38, "end": 41}]}}, "schema": []}
{"input": "Forty-eight pigs were removed from sows at 1 d of age and randomly assigned to one of three treatments: 1) control with lactose as the carbohydrate source, 2) lactose replaced (gram for gram) with CSS (dextrose equivalent [DE]-20), and 3) lactose replaced with DE-42.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS: AMVT is rare but a potentially lethal emergency disease.", "output": {"entities": {}}, "schema": []}
{"input": "Therefore, in a large animal model of permanent focal ischemia in which transfusion starts 30 min after ischemia, tetrameric cross-linked hemoglobin transfusion can augment oxygen transport to the ischemic cortex, but the increase can be delayed and not necessarily provide protection.", "output": {"entities": {"gene": [{"text": "hemoglobin", "start": 138, "end": 148}]}}, "schema": []}
{"input": "Since the early 1980s there has been increasing awareness of the importance of quantifying health-related quality of life (HRQL) in patients with chronic respiratory disorders included in clinical trials.", "output": {"entities": {}}, "schema": []}
{"input": "They were randomly allocated to receive either 625 mg of calcium carbonate (250 mg of elemental calcium) at the end of a meal three times a day (group A, n = 26) or calcium carbonate in the same manner plus 0. 625 mg/day of conjugated equine estrogen and 5 mg medrogestone acetate from day 1-12 each month (group B, n = 30).", "output": {"entities": {}}, "schema": []}
{"input": "The two-wave, 1995-1996 National Longitudinal Study of Adolescent Health uses a measure of depressive symptomatology across a 12-month interval.", "output": {"entities": {}}, "schema": []}
{"input": "METHODS: 9 cases of conventional intermittent tissue expansion (CITE) and 9 cases of continuous pressure-controlled tissue expansion (CPTE) were chosen for the study.", "output": {"entities": {}}, "schema": []}
{"input": "Wegener' s granulomatosis", "output": {"entities": {}}, "schema": []}
{"input": "There was a significant effect of hematocrit on the General Health scale on the SF-36 (P = 0. 03).", "output": {"entities": {}}, "schema": []}
{"input": "A global response rate was 17% (95% confidence interval (95% CI): 2%-32%) and the median overall survival was 12 months.", "output": {"entities": {}}, "schema": []}
{"input": "We also studied a new parameter: the angle to maximal peak torque (APT).", "output": {"entities": {}}, "schema": []}
{"input": "For the 2. 5 to 4 ng/mL model, the AUC of the ANN ROC curve was significantly higher than the AUCs for percentage of free PSA (P =. 0239), PSA-TZ (P =. 0204), and PSA density and total prostate volume (P <. 01 for both).", "output": {"entities": {"gene": [{"text": "PSA", "start": 122, "end": 125}, {"text": "PSA", "start": 139, "end": 142}]}}, "schema": []}
{"input": "Potential treatments include dobutamine, KATP channel activators, and 21-aminosteroids.", "output": {"entities": {}}, "schema": []}
{"input": "Selenium is an essential element for humans, animals and some species of microorganisms.", "output": {"entities": {}}, "schema": []}
{"input": "The GT-foreign-pictures showed that the judgment of other subjects changed toward hedonic and permeability directions.", "output": {"entities": {}}, "schema": []}
{"input": "RESULTS: The target dose was comparable in the 3D-CRT and IMRT plans, although improvements were seen when seven and nine IMRT fields were used.", "output": {"entities": {}}, "schema": []}
{"input": "We therefore applied a radiolabelled serumalbumin method to determine blood volume after haemodilution with crosslinked or conjugated haemoglobin, in comparison with a reference solution of hydroxyethyl starch (HES).", "output": {"entities": {"gene": [{"text": "serumalbumin", "start": 37, "end": 49}, {"text": "haemoglobin", "start": 134, "end": 145}]}}, "schema": []}
{"input": "The equilibrium phosphorus content (EPC0) of surface soil was generally higher than the SRP content of drainage water, at one farm by 1 order of magnitude.", "output": {"entities": {}}, "schema": []}
{"input": "The long-term prediction is based on an algorithm for R-R interval estimation.", "output": {"entities": {}}, "schema": []}
{"input": "Despite considerable research, an explanation of this effect has been elusive.", "output": {"entities": {}}, "schema": []}
{"input": "The structure has been established by a study of its mono-and bidimensional NMR spectra and mass spectrometry.", "output": {"entities": {}}, "schema": []}
{"input": "We argue that this is the general property of QSAR models developed using LOO cross-validation.", "output": {"entities": {}}, "schema": []}
{"input": "We compared the efficacy and costs of valacyclovir in preventing HSV reactivation among HSV seropositive autologous progenitor cell transplantation (APCT) patients with historical controls in whom intravenous acyclovir or no HSV prophylaxis were used.", "output": {"entities": {}}, "schema": []}
{"input": "All adults attending the outpatient clinics of a dermatological hospital on predetermined days were given the 12-item General Health Questionnaire.", "output": {"entities": {}}, "schema": []}
{"input": "Data on prosthesis use are encouraging, although a follow-up study is required to determine the functional outcome for prosthesis users and non-users.", "output": {"entities": {}}, "schema": []}
{"input": "A mail survey of Georgia members of the American College of Obstetricians and Gynecologists was conducted.", "output": {"entities": {}}, "schema": []}
{"input": "HIV-1 C subtype in IDUs accounted for 61. 3%.", "output": {"entities": {}}, "schema": []}
{"input": "When a plateau of enhancement was reached, a single lesion in each patient was imaged using five different continuous scanning modes, fundamental grey scale (FGS); fundamental colour Doppler (FCD); fundamental power Doppler (FPD); second harmonic grey scale (HGS); and pulse inversion mode (Pim) using an HDI5000 scanner and C5-2 probe (ATL, Bothell, WA).", "output": {"entities": {}}, "schema": []}
{"input": "A comparative study of the effects of carbamazepine and the NMDA receptor antagonist remacemide on road tracking and car-following performance in actual traffic.", "output": {"entities": {"gene": [{"text": "NMDA receptor", "start": 60, "end": 73}]}}, "schema": []}
{"input": "We find that the measured Nusselt number decreased about 20% over the range of Pr spanned in the experiment.", "output": {"entities": {}}, "schema": []}
{"input": "Viral and atypical pathogens as causes of type 1 acute exacerbations of chronic bronchitis.", "output": {"entities": {}}, "schema": []}
{"input": "Treatment for this condition often involves use of a wax softening or dispersing agent (cerumenolytic) before syringing.", "output": {"entities": {}}, "schema": []}
{"input": "In addition, benzocaine and 2-phenoxyethanol depressed complement activity and phagocytosis, while MS222 and quinaldine sulphate did not.", "output": {"entities": {}}, "schema": []}
{"input": "The EC (50) for suppression of long-term memory (the concentration decreasing memory by 50%) of fear conditioning to context was 2. 00% plus/minus 0. 01% (mean plus/minus SEM), and for fear conditioning to tone was 3. 45% plus/minus 0. 26%, (P < 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "It has been proposed that insulin resistance (IR) underlies a cluster of cardiovascular disease (CVD) risk factors constituting a \" metabolic syndrome. \" CVD is a leading cause of premature mortality among indigenous Australians.", "output": {"entities": {"gene": [{"text": "insulin", "start": 26, "end": 33}]}}, "schema": []}
{"input": "Dementia is being avoided in NHS and social care.", "output": {"entities": {}}, "schema": []}
{"input": "HIV-1 infection in rural Africa: is there a difference in median time to AIDS and survival compared with that in industrialized countries? OBJECTIVES: To describe the progression times of HIV-1 infection from seroconversion to AIDS and to death, and time from first developing AIDS to death in rural Uganda.", "output": {"entities": {}}, "schema": []}
{"input": "The use of highly active antiretroviral therapy (HAART) has resulted in significant improvements in the treatment of HIV infection, including a decrease in the incidence and severity of several acquired immune deficiency syndrome (AIDS)-related malignancies.", "output": {"entities": {}}, "schema": []}
{"input": "Time to progression was 6 months (5-7 months) with a median survival from registration of 9. 6 months (95% CI 8-12 months).", "output": {"entities": {}}, "schema": []}
{"input": "Heparin (100 U. kg (-1). day (-1)) was injected subcutaneously to the rats in H group while normal saline to those in N group once a day.", "output": {"entities": {}}, "schema": []}
{"input": "MAIN OUTCOME MEASURE: A positive test result for gonococcal or chlamydial infection by the ligase chain reaction assay; secondary outcome measure was a positive test result for human immunodeficiency virus (HIV).", "output": {"entities": {"gene": [{"text": "ligase", "start": 91, "end": 97}]}}, "schema": []}
{"input": "The purpose of this study was to develop a reliable and culturally meaningful exercise self-efficacy questionnaire for older Mexican American women.", "output": {"entities": {}}, "schema": []}
{"input": "Neutrophil: lymphocyte ratio, plasma haptoglobin, and CBG levels were greater (P < 0. 01) during the INITIAL period than during the PRE or POST periods but did not differ between treatments.", "output": {"entities": {"gene": [{"text": "haptoglobin", "start": 37, "end": 48}, {"text": "CBG", "start": 54, "end": 57}]}}, "schema": []}
{"input": "CD was determined using the Farnsworth D-15 method.", "output": {"entities": {}}, "schema": []}
{"input": "Here is presented the monitoring of the accidental spill on vertical distribution of heavy metals in the estuarine sediments.", "output": {"entities": {}}, "schema": []}
{"input": "The large fluxes of 239 + 240Pu might be attributed to episodic lateral transport of particles that flow down the continental slope with the nepheloid layer which was considered to be significant for 239 + 240Pu transport on the continental slope in the East China Sea.", "output": {"entities": {}}, "schema": []}
{"input": "Rigorous treatment protocols for diet delivery and EEN-related GI adverse effects were applied.", "output": {"entities": {}}, "schema": []}
{"input": "The range of 200 000-300 000 spermatozoa/microl appeared to be a reasonable compromise for both criteria.", "output": {"entities": {}}, "schema": []}
{"input": "Gastritis score was significantly lower in nod-/CagA-children than in nod +/CagA-(p =. 004), nod-/CagA + (p =. 002) and nod +/CagA + (p <. 001), both in the antrum and corpus.", "output": {"entities": {"gene": [{"text": "CagA", "start": 48, "end": 52}, {"text": "CagA", "start": 76, "end": 80}, {"text": "CagA", "start": 98, "end": 102}, {"text": "CagA", "start": 126, "end": 130}]}}, "schema": []}
{"input": "The mean thickness of the visceral peritoneum was comparable in both groups of animals, but, macroscopically, more severe fibrosis was found in the peritoneum of rats exposed to CAPD 3 as compared with animals treated with CAPD 3 Balance (p < 0. 05).", "output": {"entities": {}}, "schema": []}
{"input": "A further analysis has been performed using the series of maximum intensity for fixed duration (1, 3, 6, 12, 24 hrs) and annual daily maxima.", "output": {"entities": {}}, "schema": []}
{"input": "BACKGROUND: We hypothesized that the postoperative serum level of TA90-IC, an immune complex of a 90-kDa tumor-associated antigen and its antibody, might have a significant correlation with recurrence and survival in patients with thick primary melanomas.", "output": {"entities": {"gene": [{"text": "TA90-IC", "start": 66, "end": 73}]}}, "schema": []}
{"input": "Genetics Institute has developed and launched oprelvekin (rhIL-11; Neumega), a recombinant form of human IL-11.", "output": {"entities": {"gene": [{"text": "oprelvekin", "start": 46, "end": 56}, {"text": "rhIL-11", "start": 58, "end": 65}, {"text": "human IL-11", "start": 99, "end": 110}]}}, "schema": []}
{"input": "Patients subsequently returned to the clinic every 3 days to have the wounds checked and dressings changed.", "output": {"entities": {}}, "schema": []}
{"input": "Elements that are fundamental to the safety evaluation of flavor ingredients include exposure, structural analogy, metabolism, pharmacokinetics and toxicology.", "output": {"entities": {}}, "schema": []}
{"input": "The mass-specific resting minute ventilation (E) and the ventilatory equivalent (VE/(O (2))) were approximately the same at the two ages, with a breathing pattern significantly deeper and slower at day 1.", "output": {"entities": {}}, "schema": []}
{"input": "INTERPRETATION: It is probable that the cognitive dissonance created by more health information on smoking after 1964, i. e. the necessary motivation to quit, was reduced as a result of strategic changes in the amount and content of advertising.", "output": {"entities": {}}, "schema": []}
{"input": "Nine cases of GBS and five of TM reported to the active AFP surveillance were not found in the hospital searches.", "output": {"entities": {}}, "schema": []}
{"input": "The ability of rats with control or hippocampal lesions to learn an object-place, odor-place, or object-odor paired-associate task was assessed in a cheeseboard maze apparatus.", "output": {"entities": {}}, "schema": []}
{"input": "The shift in the earliest activation site after administration of esmolol was compared with the shift after RFA. RESULTS: The heart rate at rest and in drug-free state ranged between 95 and 125 beats/min (mean 99 +/-14 beats/min).", "output": {"entities": {}}, "schema": []}
{"input": "Urine samples collected after the administration of these supplements can test positive.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS: Lymphoscintigraphy of the cynomolgus monkey eyelids reveals discrete lymphatic drainage pathways for the upper and lower eyelids and a dual pathway for the central upper eyelid.", "output": {"entities": {}}, "schema": []}
{"input": "Data management in practice-based research.", "output": {"entities": {}}, "schema": []}
{"input": "We have previously reported reduced levels of choline acetyltransferase activity in the cerebral cortex of patients who died after a head injury, demonstrating that there is a loss of cortical cholinergic innervation.", "output": {"entities": {"gene": [{"text": "choline acetyltransferase", "start": 46, "end": 71}]}}, "schema": []}
{"input": "After taking smears from lesions of the oral mucosa (tongue, cheeks, palate) and the contiguous denture surface by cotton wool swabs and inoculating them onto Sabouraud glucose agar and CHROMagar Candida, individual yeast species were identified by a germ tube, filamentous, and assimilation tests employing the commercial kit AuxaColor.", "output": {"entities": {}}, "schema": []}
{"input": "The effects of pharmacological treatment and professional care and support may improve when dementia is detected in an early stage.", "output": {"entities": {}}, "schema": []}
{"input": "Sexually conditioned incentives: attenuation of motivational impact during dopamine receptor antagonism.", "output": {"entities": {"gene": [{"text": "dopamine receptor", "start": 75, "end": 92}]}}, "schema": []}
{"input": "PATIENTS AND METHODS: This study is a retrospective cohort study of all children with cancer admitted to a single institution with fever and neutropenia (defined as an absolute neutrophil count < 500 cells/mm3) in a 1-year period.", "output": {"entities": {}}, "schema": []}
{"input": "Concentrations of N (O3-)-N and N (H3-)-N at Deoprayag varied from 0. 30 to 0. 50 and 0. 02 to 0. 12 mg/L, respectively, depending on season.", "output": {"entities": {}}, "schema": []}
{"input": "Steal is a pathophysiological process in which increased blood flow through a low-resistance vascular bed is sufficient to divert flow away from a region of the central nervous system.", "output": {"entities": {}}, "schema": []}
{"input": "The orientations of the contact surfaces and their locations relative to the object' s center of mass were varied.", "output": {"entities": {}}, "schema": []}
{"input": "The results are given as: flux, number of stars per cm3, charge of the ions, comparison with other detectors (plastics, AgCl crystals, LiF), energy loss, hit region in the biological objects.", "output": {"entities": {}}, "schema": []}
{"input": "Nodal domains are regions where a function has definite sign.", "output": {"entities": {}}, "schema": []}
{"input": "DESIGN: Prospective, randomized, double-blind, controlled trial.", "output": {"entities": {}}, "schema": []}
{"input": "CONCLUSIONS: This retrospective uncontrolled study shows that in patients with type 1 HRS, terlipressin-induced improved renal function is associated with an increase in survival.", "output": {"entities": {}}, "schema": []}
{"input": "Calcimimetic agents directly inhibit PTH secretion by activating the calcium-sensing receptor in the parathyroid glands, but clinical experience with them is limited.", "output": {"entities": {"gene": [{"text": "PTH", "start": 37, "end": 40}]}}, "schema": []}
{"input": "The subjects were shown to be capable of assessing integrally the value of accelerations and estimating it with an error of 0. 1-0. 12 g.", "output": {"entities": {}}, "schema": []}
{"input": "The observed incidence rates were compared to expected rates in the general population.", "output": {"entities": {}}, "schema": []}
{"input": "The only predictor of response to tacrolimus was a previous response to cyclosporin and prednisone, either as a complete or partial remission (remission rate 75% vs 15. 3; P = 0. 036).", "output": {"entities": {}}, "schema": []}
{"input": "Based on a morphological study of the resin-dentine interface, a broad selection of dentine adhesive systems was classified following their adhesion-strategy.", "output": {"entities": {}}, "schema": []}
{"input": "Copyright 2002 American Cancer Society. DOI 10. 1002/cncr. 10318", "output": {"entities": {}}, "schema": []}
{"input": "As measured by the PDQ-39, STN-DBS significantly improves important aspects of QoL in patients with advanced PD.", "output": {"entities": {}}, "schema": []}