Input: The action of nef was specific to the LTR, as expression of nef had no effect on the activity of the simian virus 40, c-fms, urokinase plasminogen activator, or type 5 acid phosphatase promoter. trans-activating activity was also manifested by a frameshift mutant expressing only the first 35 amino acids of the protein.

nef

nef

c-fms

urokinase plasminogen activator

type 5 acid phosphatase promoter


Input: The product of the vpr open reading frame of human immunodeficiency virus type 1 (HIV-1) is a 15-kDa, arginine-rich protein that is present in virions in molar quantities equivalent to that of Gag.

vpr open reading frame of human immunodeficiency virus type 1 (HIV-1)

Gag


Input: The recombinant vaccinia virus-expressed mutant P1 polyproteins were analyzed for proteolytic processing defects in cells coinfected with a recombinant vaccinia virus (VVP3) that expresses the poliovirus 3CD protease and for processing and assembly defects by using a trans complementation system in which P1-expressing recombinant vaccinia viruses provide capsid precursor to a defective poliovirus genome that does not express functional capsid proteins (D.

recombinant vaccinia virus-expressed mutant P1 polyproteins

poliovirus 3CD protease

capsid precursor

capsid proteins


Input: In contrast, capsid proteins derived from the P1 precursor with a valine substitution at the amino terminus of VP1 (VP1-G001V) assembled empty capsid particles but were deficient in assembling RNA-containing virions.

capsid proteins

P1 precursor


Input: RESULTS: In an 18 moth period and out of a total of 284 positive blood cultures (154 significant isolations) 14 episodes of bacteremia by M. tuberculosis were studied in 12 prison patients coinfected by the human immunodeficiency virus with associated severe immunosuppression (mean of CD4 = 0. 068 x 10 (9)/l).


Input: Acid instilled on the larynx of maturing rabbits resulted in significant obstructive, central, and mixed apnea.


Input: By using total-protein extracts from mycelia grown under penicillin producing conditions we have detected a DNA-binding activity that specifically shifts a promoter fragment located between-654 and-455 (relative to IPNS tsp).

IPNS tsp


Input: Similar synergistic activation was observed in the IL-8 promoter, which also contains both NF-IL6 and NF-kappa B binding sites.

IL-8 promoter

NF-kappa B binding sites


Input: Notice of retraction.


Input: No homology was found between the 36K protein and known structures of proteins.


Input: We report an odd case of marked enlargement of suprapineal recess in a patient with triventricular hydrocephalus.


Input: At a PaCO2 of 40 mmHg, baseline brain pHi measured 7. 03 +/-0. 04, while regional cortical blood flow was 47. 0 +/-4. 3 ml. 100 g-1. min-1.


Input: CPAP reduced isotime (defined as the last common minute of exercise) VO2 and dyspnea in those patients with more severe lung disease, but these values tended to increase slightly in the patients with only mild lung disease.


Input: Effects of diltiazem on netilmicin-induced nephrotoxicity in rabbits.


Input: Four forms of salmonellosis were recognised in feedlots and during transport by sea: septicaemic, and acute, subacute and chronic enteric.


Input: About 20% of single-stranded DNA binding was observed in the presence of MgdTDP, but none was detectable in the absence of nucleotides.


Input: Both 4, 8-DiMeIQx and A alpha C were found at < 1 p. p. b.


Input: Three cysteine and four tryptophan residues, previously identified as conserved amongst nitrous-oxide reductases, are found in the Paracoccus enzyme.

nitrous-oxide reductases


Input: Recombinant Leishmania surface glycoprotein GP63 is secreted in the baculovirus expression system as a latent metalloproteinase.

Recombinant Leishmania surface glycoprotein GP63

metalloproteinase


Input: Delineating the molecular basis for agonist-induced destabilization of mRNA of G-protein-linked receptors that contributes to receptor down-regulation is fundamental to our understanding of long-term regulation of receptors by agonist.

G-protein-linked receptors


Input: These cells produce a low level of IL-5 when stimulated with PMA alone; however, N6, O2-dibutyryl cAMP (Bt2cAMP), in combination with PMA, augmented by more than tenfold the IL-5 production at the mRNA and the protein levels.


Input: Hu-Met-1 mRNA expression in a small number of human T cell tumor lines did not correlate with any particular phenotype or stage of development.

Hu-Met-1 mRNA


Input: Partial engorgement was higher in the treatments.


Input: In addition to the protein-tyrosine kinase domain, p56lck possesses Src homology 2 and 3 (SH2 and SH3) domains as well as a unique N-terminal region.

protein-tyrosine kinase domain

Src homology 2 and 3


Input: Strains bearing the drs2 mutation process the 20S precursor of the mature 18S rRNA slowly and are deficient in 40S ribosomal subunits.

drs2 mutation

20S precursor

mature 18S rRNA

40S ribosomal subunits


Input: Hepatitis B and liver transplantation.


Input: These combined observations define a promoter and an enhancer for the chicken L-CAM gene.

chicken L-CAM gene


Input: Clipping resulted in a serious mislocalization of the position of the peak of the epicortical potential field.


Input: The duration of diabetes mellitus in these patients was from 5 months to 6 years, and in all patients this was the first myocardial infarction.


Input: The 247-kDa complex appears to contain two distinct protein-DNA complexes of approximately 232 and 256 kDa and represents two proteins covalently cross-linked to a single DRE oligonucleotide, while the 97, 105, and 115-kDa complexes represent single protein-DRE cross-links.


Input: The promoter and upstream region of the Brassica napus 2S storage protein napA gene were studied to identify cis-acting sequences involved in developmental seed-specific expression.

Brassica napus 2S storage protein napA gene


Input: However, limited comparisons reveal domains in the NH2 and COOH termini that have a high degree of similarity suggesting functional conservation.


Input: Rinit reflects the Newtonian resistances and Rdiff represents the viscoelastic/inhomogeneous pressure dissipations in the system.


Input: We have explored the mechanism of action of the fibronectin splicing enhancer and found that the SE element is required for efficient assembly of early splicing complexes, allowing a more efficient interaction of the U2 snRNP with branch site sequences.

fibronectin splicing enhancer

U2 snRNP


Input: Inspection of enhancer mutants suggests that trans-activation by hLEF/GAL4 is especially dependent on TCF-2, a distinct T-cell-enriched protein that binds to sequences flanking the hLEF-binding site in the enhancer.

hLEF

hLEF-binding site


Input: We conclude that sequences outside of the hLEF HMG box mediate cell-and context-specific activation of the TCR alpha enhancer and may facilitate interactions between hLEF and other T-cell-specific factors recruited to the enhancer.

hLEF HMG box

TCR alpha enhancer

hLEF


Input: A cAMP response element (CRE) consensus signal was identified in the 5'-noncoding region. cAMP regulates the expression of Kv1. 5 gene in a cell-specific manner.

Kv1. 5 gene


Input: A number of serological tests measuring the presence of Helicobacter pylori-specific serum immunoglobulin G (IgG) are now commercially available.

immunoglobulin G

IgG


Input: Using a series of mutant T antigens expressed by recombinant baculoviruses in Sf9 cells, we find that the origin unwinding activities of both TS677--> A and TS677, 679--> A are inhibited by the T-antigen kinase, as is wild-type T antigen.

mutant T antigens

T-antigen kinase

wild-type T antigen


Input: The degree of hypoperfusion was slightly related to decrease in FEV1. 0%, V25 and PaO2 and increase in circulating blood volume and peripheral red blood cell counts.


Input: In the present study, lesions of the OPT complex (the thalamic source of afferents to IHA and HD) were found to have no effect on color-reversal learning performance.


Input: The fourth dose produced favorable results (66. 7%) in individuals with HB antibodies between 10 and 100 IU/ml and unfavorable ones (3. 8%) where the HB antibodies were below 10 IU/ml.

HB antibodies

HB antibodies


Input: CONCLUSIONS: In our patients and within the range of treatment variables studied, age, Karnofsky index, and graft-versus-host disease are the most important factors related with early mortality.


Input: Nucleotide sequence analysis of the HA gene in these two mutants confirmed the HA-phenotype.

HA gene

HA-


Input: This intron occupies a conserved position corresponding to that of intron 1 in the transit peptide region of chloroplast GAPDH genes (GapA and GapB) of higher plants.

chloroplast GAPDH genes

GapA

GapB


Input: The drug-resistant cell lines P388/ADR/3 and P388/ADR/7 express a shortened topo II alpha mRNA transcript in addition to the native transcript present in the drug-sensitive P388/4 cell line.

topo II alpha mRNA transcript


Input: Using a 3'-rapid amplification of cDNA ends strategy, we have cloned cDNAs representing the 3'-termini of both the native and mutant transcripts from both P388/ADR/3 and P388/ADR/7 cells.


Input: The phi AP3 factor is a nuclear phosphoprotein; the extent of its phosphorylation is regulated during the cell cycle.

phi AP3 factor


Input: Similarly, the N-terminal cytoplasmic domain of the latent membrane protein 2A (LMP2A) of the Epstein-Barr virus (EBV) contains a single copy of the Tyr-X-X-Leu/Ile-containing motif which could play a critical role in B cell transformation.

latent membrane protein 2A


Input: The functional homology of Cwg2 with Cdc43, which has been implicated in the control of cell polarity, suggests a link between two morphogenetic events such as establishment of cell polarity and cell wall biosynthesis.


Input: Molecular cloning of a P-type ATPase gene from the cyanobacterium Synechocystis sp.

P-type ATPase gene


Input: The cloning of PTR2 represents the first example of the molecular genetic characterization of a eucaryotic peptide transport gene.


Input: To examine the biochemical basis of the end joining, nuclear extracts were prepared from a wide variety of mammalian cell lines and tested for their ability to join test plasmid substrates.


Input: These data indicate that the largest subunit of RNA polymerase II and TFIIB are important determinants of transcription start site selection in S. cerevisiae and suggest that this function might be conferred by interaction between these two proteins.

RNA polymerase II

TFIIB


Input: Recombinant expression of a chimeric EGFR/ErbB-3 receptor in NIH 3T3 fibroblasts allowed us to investigate cytoplasmic events associated with ErbB-3 signal transduction upon ligand activation.

EGFR

ErbB-3 receptor


Input: Analysis of strains harboring an mds1 null mutation demonstrates that MDS1 is not essential during normal vegetative growth but appears to be required for meiosis.

mds1 null mutation


Input: Val--> Ala mutations selectively alter helix-helix packing in the transmembrane segment of phage M13 coat protein.

phage M13 coat protein


Input: Strategic change in the NHS.


Input: A much less expensive solution than UW, containing only K (+)-lactobionate, KH2PO4, MgSO4 and raffinose, can be used successfully for preservation of rat hepatocytes for 24 hr for drug transport studies.


Input: Human bcl3 protein specifically displaces (p50) 2-DNA complexes.

Human bcl3 protein

(p50) 2-DNA complexes


Input: In vitro translation experiments show that human cDNA derived RNA translates into a protein with a mobility of 44-46 kD on SDS polyacrylamide gels.


Input: After peripheral administration of both CRF and TRH, ACTH levels were significantly higher on the tumor side in all patients.

CRF

TRH

ACTH


Input: A sequence homology analysis between human nm23-H1 and the homolog gene of the rat (NDP-K beta) shows that exon-intron boundaries are well conserved between these two species.

human nm23-H1

NDP-K beta


Input: A favourable response was achieved with a combination of amphotericin B and cotrimoxazole.


Input: Response durations were short.


Input: RESULTS: At the beginning of the QA/QI process, monitoring of blood administration practices revealed that a variance from institutional blood administration policy occurred during 50 percent of blood and component transfusions.


Input: Drug effect, measured as postural sway, was also similar in the patients with cirrhosis and control subjects; therefore the ratio of effect area under the curve to concentration area under the curve, a measure of sensitivity, did not differ significantly between the patients with cirrhosis and the control subjects.


Input: We present evidence that YY1, a ubiquitously expressed DNA-binding protein, regulates the activity of the c-fos promoter primarily through an effect on DNA structure.

c-fos promoter


Input: In a retrospective analysis of first-time total colonoscopies in 685 patients, we investigated the relationship between hyperplastic and adenomatous polyps.


Input: The rate of decrement in DPOAE amplitude over a prescribed time period was utilized as a measure of susceptibility to the acoustic trauma.


Input: Effect of single base substitutions at glycine-870 codon of gramicidin S synthetase 2 gene on proline activation.

gramicidin S synthetase 2 gene


Input: The predicted Pay4p sequence contains two putative ATP-binding domains and shows structural relationships to other potential ATP-binding proteins involved in biological processes as diverse as peroxisome biogenesis, vesicle-mediated protein transport, cell cycle control, and transcriptional regulation.

Pay4p sequence

ATP-binding proteins


Input: The results show that the structure of the decorin gene promoter is different from that of any other proteoglycan promoter characterized so far and indicate that the pur/pyr segment plays a role in the regulation of gene transcription.

decorin gene promoter


Input: The kinase inhibitor staurosporine (1 microM) blocks LPA-induced, but not epidermal growth factor-induced, activation of p21ras and MAP kinase, consistent with an intermediate protein kinase linking the LPA receptor to p21ras activation.

MAP kinase

LPA receptor


Input: 267, 4870-4877)) indicates an overall identity of 58 and 56%, respectively, with a 91 and 92% identity in the highly conserved transmembrane and cytoplasmic domains.


Input: S., K.


Input: The survival rate at forty months in 15 patients with N2 disease who underwent R2b operation was 51%.


Input: Mothers with severe anatomical abnormalities, who are HIV positive, have active TB or whose children have inherited mono-or disaccharide intolerances should not breastfeed.


Input: G.


Input: The psaD, psaF, psaH, and psaL products have two isoforms each that are distinguished by different mobilities in polyacrylamide gel electrophoresis, and the psaE product has four isoforms.

psaD

psaF

psaH

psaL products

psaE product


Input: When Hy-Vac SPF type V embryos were exposed to either 0. 20 ml 50% ethanol in CRS or to 0. 20 ml CRS (controls), ethanol-treated embryos showed a VSD incidence of 34. 1% compared with a 3. 6% incidence in the controls (P = 0. 0017).


Input: Peripheral vitreochorioretinal dystrophies in myopia patients


Input: The secondary, but not the primary, antibody responses of male C57Bl/6 mice were higher among mice housed alone compared to mice housed in groups; differences were observed for both IgM and IgG anti-KLH antibodies.

IgM

IgG anti-KLH antibodies


Input: However, a surprisingly high degree of conservation of intron sequences was observed between both species.


Input: Interleukin-6 may possibly potentiate metastasis of cardiac myxoma.


Input: Other parameters of iron metabolism, including ferritin, were not found to contribute to the risk.

ferritin


Input: Responses to the Plowright Rinderpest vaccine by 43 calves and 70 adult cattle in Uganda in 1990, through the production of IgG antibodies, were monitored for 4 weeks using the ELISA assay.

IgG antibodies


Input: Tumours of the cavum oris and oropharynx of T1-stage are possible only in 1 of 3 cases.


Input: Thomas' Hospital solution (with 95% O2: 5% CO2) can meet the metabolic demand of the ischaemic myocardium and thus increase the safe duration of cardiac arrest.


Input: Plasma, LDL and liver cholesterol concentrations were higher in the hyperlipidemic control than the nonhyperlipidemic control and lower in the groups fed diets containing pectin or prune fiber than in the hyperlipidemic control group.

LDL

pectin


Input: Routine psychometric screening of IHD patients may provide a cost-effective means of alerting cardiologists and internists to the relatively high levels of distress among their patients.


Input: Employing this sequence information from c11/1, the c11/1-specific cDNA was generated from poly (A) + RNA of bovine PMNLs by reverse transcription and a combination of polymerase chain reaction (PCR) methods.


Input: The deduced amino acid sequence of the mouse HO-1 gene is identical to that of p32, initially identified as a stress-induced protein in mouse BALBc/3T3 cells.

mouse HO-1 gene


Input: Using a polymerase chain reaction-based approach, we cloned a 150-base pair fragment of a new sialymotif from human placenta mRNA, which was then used as a probe to clone the complete coding sequence of the corresponding gene from a cDNA library.


Input: The structural analysis also demonstrated that the heterogeneity of the HDC mRNA is caused by an insertion of the seventh intron sequence and alternative use of the splicing acceptor site at the 12th exon.

HDC mRNA


Input: A complementary DNA was isolated from Caenorhabditis elegans that encoded a polypeptide of 1438 amino acid residues, CeGAP, which contains a domain with sequence similarity to the COOH-terminal segment (GTPase-activating protein region) of Bcr and other known GTPase-activating proteins of the Rho subfamily.

CeGAP

COOH-terminal segment (GTPase-activating protein region)

Bcr

GTPase-activating proteins

Rho subfamily


Input: Additional exonuclease III protection was observed beyond the core region on both the 5' and 3' sides, suggesting that E1 interacted with more distal sequences as well.

exonuclease III


Input: Repression is alleviated when the two (for E2) or three (for E2-C) promoter-proximal copies of E2-RS are mutated.


Input: A mutant in the AAV terminal resolution site (trs) was defective for DNA replication in the in vitro assay.


Input: The results indicate that rep strongly enhances the function of negative regulatory elements of the LTR.

rep


Input: The Oct-3/4 gene product, which belongs to the POU family of transcription factors, is a good candidate for regulating initial differentiation decisions.

Oct-3/4 gene product

POU family of transcription factors


Input: Using site-directed mutagenesis, we show that the RAREoct contributes to the transcriptional activation of Oct-3/4 promoter in P19 cells and, most interestingly, mediates the RA-induced repression in RA-differentiated EC cells.

RAREoct

Oct-3/4 promoter


Input: 176: 787-792, 1992; M.


Input: Furthermore, the negative transcriptional effect of COUP-TFs is dominant over the activating effect of the Oct4 embryonic stem cell-specific enhancer.

COUP-TFs

Oct4 embryonic stem cell-specific enhancer


Input: Analysis of mig/CAT chimeric constructs transiently transfected into the RAW 264. 7 mouse monocytic cell line revealed a unique IFN-gamma-responsive element (gamma RE-1).

mig

CAT

IFN-gamma-responsive element

gamma RE-1


Input: When expressed alone in test cells, Atr-I is unable to bind TGF-beta, activin, or bone morphogenetic protein 2.

Atr-I

TGF-beta

activin

bone morphogenetic protein 2


Input: Therefore, Mxi1 and Mad might antagonize Myc function and are candidate tumor suppressor genes.

Mad

Myc


Input: To our knowledge, type IV renal tubular acidosis has not been reported previously in association with Alport' s syndrome in an adult patient.


Input: A cDNA clone was isolated from a chicken embryo cDNA library employing a PCR-generated radiolabeled probe specific for the U3 region of the Rous sarcoma virus LTR.

U3 region

Rous sarcoma virus LTR


Input: Two basic patterns of locomotor behavior and corresponding torso morphology exist among extant anthropoids.


Input: Animal age and sex had no significant effects on CSF composition, but serum IgG concentration increased with age.

IgG


Input: Fast continuous expansion.


Input: A randomized, multicenter study comparing the efficacy and tolerability of tropisetron, a new 5-HT3 receptor antagonist, with a metoclopramide-containing antiemetic cocktail in the prevention of cisplatin-induced emesis.

5-HT3 receptor


Input: Each repeat consists of 12 nt, coding for the reiterated sequence, K/NPAG.


Input: BACKGROUND: To determine the predictors of desipramine-refractory depression, the authors examined the outcome in patients with major depression who were admitted to a general hospital and treated with desipramine adjusted to an adequate blood level.


Input: Analysis of the intact hGH gene or hGH 5'-flanking DNA (5'-FR) coupled to the hGh cDNA or chloramphenicol acetyltransferase or luciferase genes, indicated that cAMP primarily stimulated hGH promoter activity.

hGH gene

hGH 5'-flanking DNA (5'-FR)

hGh cDNA

chloramphenicol acetyltransferase

luciferase genes

hGH promoter


Input: The predicted amino acid sequence of the SAP-1 cDNA showed that mature SAP-1 consisted of 1093 amino acids and a transmembrane-type PTP, which possessed a single PTP-conserved domain in the cytoplasmic region.

SAP-1 cDNA

mature SAP-1

transmembrane-type PTP

PTP-conserved domain


Input: Several features of 10. 24. 6 cells suggest that the mutation disrupts normal intracellular formation of peptide/DR complexes.

peptide/DR complexes


Input: This distribution parallels that of the neurotransmitters glutamate and aspartate; however, neither of these excitatory amino acids is a substrate for transport.


Input: The Harleco apparatus is a simple, useful, cost-effective adjunct to the diagnosis and treatment of this life-threatening condition.


Input: Co-transfection of expression vectors for CCAAT/enhancer binding protein (C/EBP) alpha and C/EBP beta trans-activated the rat uncoupling protein gene promoter due to sequences in the 5' proximal region.

CCAAT/enhancer binding protein (C/EBP) alpha

C/EBP beta

rat uncoupling protein gene promoter


Input: It was not possible to study the basis for tissue-specific expression of this gene, because the beta 3 gene promoter had not been isolated previously.

beta 3 gene promoter


Input: Isolation and characterization of a TATA-less promoter for the human beta 3 integrin gene.

human beta 3 integrin gene


Input: Subretinal fluid was punctured on the poorer eye in 19 eyes (52. 7%) and on the better eye in 7 eyes (19. 4%).


Input: These data indicate that activation of these enzymes is not sufficient for the acute stimulation of glucose transport.


Input: The inserted region, which represents an intron in brain and muscle, is expressed in the tumor cell lines either as a " readthrough " form or with 78 residues deleted from its 5' end.


Input: Concordance of IBDQ scores was tested in 280 stable subjects.


Input: Regression line slopes of IBDQ scores were significantly different in patients who deteriorated from those who remained stable ([b] < 0. 15; P < 0. 0001).


Input: Inhibition of erythromycin synthesis by disruption of malonyl-coenzyme A decarboxylase gene eryM in Saccharopolyspora erythraea.

malonyl-coenzyme A decarboxylase gene eryM


Input: This region is required for activation of DNA binding of MyoD and E12 homodimers and E12/MyoD heterodimers.

MyoD

E12 homodimers

MyoD


Input: Site-directed mutagenesis of the traI structural gene and application of purified mutant TraI proteins for in vitro assays served to evaluate the functional importance of conserved amino acid residues.

traI structural gene

TraI proteins


Input: Concerted action of three distinct domains in the DNA cleaving-joining reaction catalyzed by relaxase (TraI) of conjugative plasmid RP4.

relaxase

TraI


Input: The COOH-terminal 46 codons of slyD encode a remarkable histidine-rich peptide sequence which is at least partly dispensable for slyD function in E-mediated lysis.

slyD

slyD

E


Input: We studied GSH-Px enzyme activity in serum after acute myocardial infarction (AMI) and unstable angina pectoris (UAP).


Input: The HGF-induced cell motility was mimicked by 12-0-tetradecanoyl-phorbol-13-acetate, a protein kinase C-activating phorbol ester, but not by Ca2 + ionophore.

HGF

protein kinase C


Input: In addition, lexical priming was examined by presenting an identity prime earlier in the text.


Input: METHODS: Forty-nine cases with intrahepatic multiple nodules of HCC, by gross examination, among 184 consecutive resected HCCs were examined clinicopathologically.


Input: In the present report, 66 hemochromatosis families yielding 151 hemochromatosis chromosomes and 182 normal chromosomes were RFLP-typed with a battery of probes, including two newly derived polymorphic markers from the 6. 7 and HLA-F loci located 150 and 250 kb telomeric to HLA-A, respectively.

HLA-F loci

HLA-A


Input: Pneumothorax during laparoscopic dissection of the diaphragmatic hiatus.


Input: Different cortical malformations were produced in rats by a single dose of X-rays (200 cGy) given on different days during gestation.


Input: T2 cancers should not be excluded from the benefit of preoperative irradiation.


Input: IFN alpha and IFN gamma inducibility is mediated by a single element: a high affinity, nearly palindromic version of the IFN gamma activation site (GAS).

IFN alpha

IFN gamma

IFN gamma activation site

GAS


Input: Twenty-three sequence-tagged sites (STSs) were mapped within the contig, a density of approximately 1 per 200 kb.


Input: In this paper, we demonstrate that binding of the GA-binding protein (GABP) to ets sequence motifs within each repeated unit is required for transcriptional activation of the COXIV promoter.

GA-binding protein

GABP

ets sequence motifs

COXIV promoter


Input: To gain further insight into the pathogenesis of the adult respiratory distress syndrome (ARDS), the authors studied possible relationships among the activation status of circulating polymorphonuclear neutrophils (PMN), cytokine levels, and the severity of lung injury in 31 patients: 15 with ARDS, 9 with severe pneumonia uncomplicated by ARDS, and 7 mechanically ventilated patients with neither ARDS nor pneumonia.


Input: Amiodarone, seldom used as first-line treatment, appears to be the most effective drug.


Input: These results demonstrate that dopamine receptor stimulation by different dopamine agonists produces a different pattern of effects on the characteristics of the reaction time response.

dopamine receptor


Input: Two experiments were conducted to study the vacuous jaw movements induced in rats by acute administration of the monoamine-depleting agent reserpine.


Input: Depletion of dopamine in the nucleus accumbens led to a dramatic shift in behavior in which there was a significant decrease in lever pressing but a significant increase in consumption of lab chow.


Input: We have investigated the influence of NaFe3 + EDTA, and of increasing dietary levels of Na2EDTA, on Zn, Cu and Ca metabolism in rats fed on Zn-sufficient and Zn-deficient soya-bean-isolate-based diets.


Input: Recovery of carbimazole-induced agranulocytosis following recombinant granulocyte-macrophage colony stimulating factor (rhGM-CSF) administration.

recombinant granulocyte-macrophage colony stimulating factor

rhGM-CSF


Input: Thus, the system can be used to detect and study dynamic perfusion changes from the brain surface with minimal tissue damage.


Input: The neglect of Richards' s theory demonstrates the range of factors, other than the strictly scientific, which can be important in determining the influence or otherwise of a psychological theory.


Input: The positive-acting global sulfur regulatory protein, CYS3, of Neurospora crassa turns on the expression of a family of unlinked structural genes that encode enzymes of sulfur catabolism.


Input: Analysis of the upstream untranslated region of CHL15 revealed the presence of the hexamer element, ACGCGT (an MluI restriction site) controlling both the periodic expression and coordinate regulation of the DNA synthesis genes in budding yeast.

MluI restriction site


Input: The C-terminal region of the 150-kDa protein contains an NTP-binding helicase motif and the readthrough region, an RNA polymerase motif, indicating that these two overlapping proteins may form an RNA replication complex similar to those of tobamo-and tobraviruses.

helicase motif

RNA polymerase motif


Input: On T2 weighted images, low intensity areas in the thalamus, the striatum, the anterior limb of the internal capsule, the tegmentum of midbrain, high intensity areas in middle cerebellar peduncle, the posterior limb of the internal capsule, the lateral part of the cerebral peduncle, and the cerebral white matter were noted.


Input: Using the rap1t alleles to generate wild-type cells differing only in telomere tract lengths, we also show that telomere position effects are highly sensitive to changes in the size (or structure) of the telomeric tract.

rap1t alleles


Input: Pronounced microangiopathy characterized by avascular fields, enlarged and tortuous capillaries and increased transcapillary diffusion of sodium fluorescein, was clearly demonstrable in the area of the nodules.


Input: Epigenetic switching of transcriptional states: cis-and trans-acting factors affecting establishment of silencing at the HMR locus in Saccharomyces cerevisiae.

HMR locus


Input: The two methods identify the same patients only if micturitional pressures are normal (40 to 60 cmH2O) to high (over 60 cmH2O) and the Sussett formula is used with a higher (95th centile) cutoff.


Input: There was no clear correlation between the MFA and the severity of the UTS phenotype.


Input: Chicken sterol carrier protein 2/sterol carrier protein x: cDNA cloning reveals evolutionary conservation of structure and regulated expression.

sterol carrier protein 2

sterol carrier protein x


Input: The plasmatic albumin concentration (3. 5-4. 5 g/dl) represents about 60% of the total plasma protein.

plasmatic albumin


Input: A single five minute period of rapid atrial pacing fails to limit infarct size in the in situ rabbit heart.


Input: Neither RD19 nor RD21 mRNA synthesis was responsive to cold or to heat stress.

RD21 mRNA


Input: Previous studies indicated that the 20S proteasome is a catalytic core of the 26S proteolytic complex that possesses a latent multicatalytic proteinase activity and catalyzes an ATP-dependent, selective breakdown of proteins ligated to ubiquitin.

20S proteasome

26S proteolytic complex

ubiquitin


Input: The O2 deficit was not related to blood lactate during submaximal exercise, muscle enzyme activity (citrate synthase, 3-hydroxyacyl-CoA-dehydrogenase, lactate dehydrogenase), number of muscle capillaries,% ST fibres or muscle buffer capacity.

citrate synthase

lactate dehydrogenase


Input: The sequence of the putative RBP1 protein contains two copies of an RNA recognition motif, two glutamine stretches, an asparagine-rich region, a methionine-rich region, and two long potential alpha-helixes.

RBP1 protein


Input: One defective RNA with a large deletion in the p70 coding region was able to replicate efficiently, both when inoculated with the helper genome and when inoculated with a second complementing defective RNA that supplied a wild-type p70.

p70 coding region

wild-type p70


Input: Complete nucleotide sequence of the bacteriophage K1F tail gene encoding endo-N-acylneuraminidase (endo-N) and comparison to an endo-N homolog in bacteriophage PK1E.

bacteriophage K1F tail gene

endo-N-acylneuraminidase

endo-N

endo-N homolog


Input: Binding of U2 small nuclear ribonucleoprotein was partially inhibited.

U2 small nuclear ribonucleoprotein


Input: Morphometrical quantification of brain edema related to experimental multiple micro-infarcts in mice: assessment of neurotropin effect.

neurotropin


Input: One member of this multigene family, GATA-3, is most abundantly expressed in T lymphocytes, a cellular target for human immunodeficiency virus type 1 (HIV-1) infection and replication.


Input: Indeed, significant level of CAT activity was observed in human lung adenocarcinoma (A549-1) cells which had been incubated with a complex of T7 RNA polymerase, pT7-EMC-CAT DNA and DC-chol cationic liposomes.

CAT

T7 RNA polymerase

pT7-EMC-CAT DNA


Input: Pneumoscrotum is a rare condition that receives little discussion in standard texts of urology.


Input: The first gene codes for a protein containing 11 cystein residues in an arrangement typical for Fe/S proteins.

Fe/S proteins


Input: Triton-disrupted cells retained capacity for activation of the pathway by both peptide growth factors and by addition of GTP-loaded p21 rasVal12.

p21 rasVal12


Input: To begin to examine the mechanism controlling expression of this gene during the cell-cycle, a mouse B-myb 5' flanking sequence was isolated from a cosmid library and shown to promote efficiently the transcription of a luciferase reporter gene when transfected into NIH3T3 fibroblasts.

mouse B-myb 5' flanking sequence

luciferase reporter gene


Input: The influence of a high ionic strength on the resolution was clearly shown.


Input: The number of bacteria in the lung, peripheral white blood cell and BAL fluid cell also decreased by the administration of FN.

FN


Input: In mice, three major families of L1 elements, termed " A, " " F, " and " V, " have been defined on the basis of the sequence found at the 5' terminus.


Input: TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation.

TFEC

basic helix-loop-helix protein


Input: Similar results were seen on Western blots of Autographa californica MNPV (AcMNPV)-infected Spodoptera frugiperda cells.


Input: In infected mammalian cells, the ARV G and GNS genes are transcribed primarily as a polycistronic mRNA which appears to extend from the consensus sequence (AACAG) at the start of the G gene to the next recognized polyadenylation signal (CATG [A] 7) located 697 nucleotides downstream of the GNS protein termination codon.

ARV G

GNS genes

G gene

GNS protein


Input: Molecular cloning and expression of RPE65, a novel retinal pigment epithelium-specific microsomal protein that is post-transcriptionally regulated in vitro.


Input: The mean power (in mu W) required to produce the observed flow rate was estimated at each outflow pressure as the product of the flow rate and the pressure across the lymphatic vessel.


Input: Although antisperm antibodies are associated with infertility, many hospital laboratories do not test for these antibodies.


Input: PPD-specific IgG subclass responses were evident to all four IgG subclasses.

PPD

IgG

IgG


Input: Anterior body pattern in Drosophila is specified by the graded distribution of the bicoid protein (bcd), which activates subordinate genes in distinct anterior domains.

bicoid protein

bcd


Input: GAP-N bound constitutively to p190 in both serum-deprived and growth factor-stimulated cells.

GAP-N


Input: The peptide sequence contains a region of 80 amino acids that shows similarity to bcl-2 and to the recently described bcl-2-related gene, MCL1.

bcl-2-related gene


Input: The phosphorylation efficiency is improved by increasing the number of N-terminal arginine residues and by moving the arginyl cluster one residue further away from the serine, the nonapeptide (Arg) 4-Ala-Ala-Ser-Val-Ala being the best substrate among all the short peptides tested (Km = 15 microM).


Input: The Saccharomyces cerevisiae GAL1 and GAL10 genes are controlled in response to the availability of galactose and glucose by multiple activating and repressing proteins bound at adjacent or overlapping sites in UASG.

Saccharomyces cerevisiae GAL1

GAL10 genes


Input: Surprisingly, the results of several experiments suggest that the TSF genes encode global regulatory factors. tsf1 to tsf6 mutations derepressed expression from yeast CYC-GAL hybrid promoters (fused to lacZ) that harbor a variety of operator sequences, and caused pleiotropic defects in cell growth, mating, and sporulation.

TSF genes

CYC

GAL

lacZ


Input: Sex of calf (variate 2) was associated most closely with width of muzzle and head.


Input: Sequence comparison indicates that exons 5'/L and L/N in PSG12 and PSG12 psi are 99% identical, except that the L/N exon in the PSG12 psi gene contains a stop codon.

PSG12 psi

PSG12 psi gene


Input: The mechanisms that govern the activation or suppression of the CD8 gene are likely to be central to the T cell development program.

CD8 gene


Input: We suggest that the ER lumenal variable domain of gp19K has a specific tertiary structure that is important for binding to the polymorphic alpha 1 and alpha 2 domains of class I heavy (alpha) chains.

class I heavy (alpha) chains


Input: We recently found that 17 beta-estradiol (E2) not only suppresses bone resorption but also stimulates bone formation in the cancellous bone of female rats.


Input: Recombinant human erythropoietin (epoetin) is approved to be administered by the intravenous (i. v.) or subcutaneous (SC) route.

Recombinant human erythropoietin

epoetin


Input: Single-photon emission computed tomography (SPECT) with 99mTc-hexamethylpropyleneamine oxime (HMPAO) was used to investigate changes in cerebral blood flow in seven patients with cortical visual impairment.


Input: The rCBF ratio was mainly reduced in frontal lobes (65%).


Input: METHODS: Twenty-two patients were grouped according to their etiology based on the study of antiadrenal antibodies at diagnosis of the disease: 7 were positive (autoimmune etiology or EAA), 11 were negative (tuberculous etiology or EAT) and in four serologic study was not available (undetermined etiology or EAI).


Input: The UV induction of c-jun is mediated by two UV response elements consisting of AP-1-like sequences within its 5' control region.

c-jun

AP-1-like sequences


Input: Protein tyrosine phosphatases (PTPs), together with protein tyrosine kinases (PTKs), are involved in the regulation of cell activation, growth, and differentiation.

Protein tyrosine phosphatases

PTPs

protein tyrosine kinases

PTKs


Input: ST elevation occurs in 5 patients (55. 5%) of subgroup A and in no patient of the subgroup B.


Input: Furthermore, a p21X protein lacking the N-terminus of Rex1 was expressed at high levels; our data indicate that p21X is translated from the 1. 6-kb mRNA which is derived primarily from deleted proviruses.

p21X protein


Input: HTLV-1 gene expression by defective proviruses in an infected T-cell line.


Input: Thus, it was confirmed that the sodium lauryl sulfate method of estimating hemoglobin concentration is an appropriate alternative to the cyanmethemoglobin method and avoids the generation of toxic wastes.

hemoglobin

cyanmethemoglobin


Input: A comparison of the predicted amino acid sequences of the two human PKC-delta clones with the rat and mouse homologues indicated a greater degree of sequence divergence (89-90% homology) compared to the high degree of sequence conservation observed with other human PKC family members and their mammalian counterparts.

human PKC-delta

human PKC family members


Input: XII.


Input: When comparing the barley PSI-K and PSI-G with the reported PSI-K sequence from Synechococcus vulcanus, the degree of similarity is equal, suggesting that an ancestral gene has been duplicated in a chloroplast progenitor but not in a cyanobacterial.

barley PSI-K

PSI-G

PSI-K sequence from Synechococcus vulcanus


Input: Under these conditions, transfections with cDNAs of the NF-kappa B p50 and serum response factor (SRF) produced a factor (s) that mediated Tax binding to the NF-kappa B site and the CArG box respectively.

NF-kappa B p50

serum response factor

SRF

Tax

NF-kappa B site


Input: We show here that v-Rel specifically increased expression from a reporter plasmid containing multiple Sp1 binding sites approximately sixfold in chicken embryo fibroblasts (CEFs), even though v-Rel did not bind directly to these sites. v-Rel also increased expression from a reporter plasmid containing a human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) in which the kappa B binding sites were mutated but which still contained intact Sp1 binding sites.

v-Rel

Sp1 binding sites

v-Rel

v-Rel

human immunodeficiency virus type 1 (HIV-1) long terminal repeat

kappa B binding sites

Sp1 binding sites


Input: The simultaneous recording of electrical activity from the surface electrocardiogram, right ventricular apex, His bundle, high right atrium, coronary sinus, with or without a roving mapping catheter, enables us to precisely map the electrical activation sequence in the heart.


Input: CONCLUSION: This retrospective analysis does not confirm the efficacy of one course of simultaneous Mitomycin-C and 5-fluorouracil, at least in association with full-dose radiotherapy incorporating Iridium-192 boost.


Input: Despite the existence of 30 cysteine residues, carboxymethylation prevented the formation of most if not all disulfide bonds that otherwise occurred when the cells were sonicated.


Input: Cerebro-oculo-facioskeletal syndrome (Pena-Shokeir syndrome II)


Input: Most importantly, the addition of purified 17S U2 snRNPs, but not of 12S U2 snRNPs, to HeLa splicing extracts in which the endogeneous U2 snRNPs have been functionally neutralized with anti-PRP9 antibodies fully restores the mRNA-splicing activity of the extracts.

17S U2 snRNPs

12S U2 snRNPs

endogeneous U2 snRNPs

anti-PRP9 antibodies


Input: Differences in profiles of viscosity variables between subgroups of EAD in RA patients were observed.


Input: These contain a single 1977-bp exon that encodes 900 bp of the 5' and 3' untranslated sequences in addition to a 1077-bp open reading frame identical to that found in vascular smooth muscle cell AT1a receptor cDNAs.

vascular smooth muscle cell AT1a receptor cDNAs


Input: Deletion of a 53-bp early promoter region containing the transcription start site and a putative TATA box completely abolishes the ability of upstream elements to drive transcription of the luciferase cDNA.

luciferase cDNA


Input: One chimpanzee reliably selected the larger numeral 4 during testing with a nonadjacent pair (2-4), and 2 chimps showed no preference.


Input: Dissipation of claudication pain after walking: implications for endurance training.


Input: Alternative transcript of the nonselective-type endothelin receptor from rat brain.

endothelin receptor


Input: The Drosophila clathrin heavy chain gene: clathrin function is essential in a multicellular organism.

clathrin heavy chain

clathrin


Input: The binding specificity of this protein was compared to that of human E2F using a number of mutant E2F sites as competitors.

human E2F

mutant E2F sites


Input: To analyze the VH regions of polyreactive antibodies, with particular attention at their somatically mutated status, we generated five IgG (three IgG1 and two IgG3) mAb (using B cells from a healthy subject, a patient with insulin-dependent diabetes mellitus and a patient with SLE), which bound with various efficiencies a number of different self and foreign Ag.

IgG

insulin


Input: It is possible that the patch determines the proper conformation of the site and thereby contributes to recognition indirectly.


Input: The 7-kb mRNA differs by alternative splicing such that it encodes a protein with a distinct amino terminus.


Input: Kinetics of the inhibition indicated that this polymerase domain can inhibit viral replication only during the preinitiation stage.


Input: McCann III, F.


Input: In order to investigate to what extent this interaction might contribute to tumor induction by the virus, we have introduced two different point mutations within the putative pRb-binding sequence of large T antigen, and as a preliminary to in vivo experiments we have studied their effects in vitro on some biological activities relevant to tumor induction.

pRb-binding sequence

large T antigen


Input: We conclude that the conservation of nucleotides 154 to 156 is likely to be a consequence of their role as a sequence-specific recognition element for the SRP54 protein.

SRP54 protein


Input: A region of the deduced protein shares extensive homology with a catalytic region of Raf kinases, a feature shared only with TFIIE among transcription factors.

Raf kinases

TFIIE


Input: The low molecular mass polypeptide complex is assumed to be involved in antigen presentation, generating peptides from cytosolic protein antigens, which are subsequently presented to cytotoxic T-lymphocytes on the cell surface.


Input: Secondary cleavage of RT at Trp-595-Tyr-596 of Pol yields a truncated form lacking the C-terminal RNase H domain.

RT

Pol

C-terminal RNase H domain


Input: The C-terminal approximately 50 amino acids of Bel-1 are shown to be essential for Bel-1 activity but can be effectively substituted by the C-terminal activation domain of VP16.


Input: Since the-172/-148 element also conferred estrogen and thyroid hormone responsiveness, it can be considered a composite hormone response element.


Input: Optimal activation of T cells requires at least two signals.


Input: Together with a considerably shortened and interrupted aromatic aa stretch in this region, these differences are discussed in terms of the peculiar affinity of cyanobacterial cytochrome oxidases for acidic c-type cytochromes.

cyanobacterial cytochrome oxidases

c-type cytochromes


Input: All four of the genes have a similar structure, with the receptor protein encoded in a single exon.


Input: Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters.

GABP

cytochrome oxidase

ETS domain


Input: The intracellular basic region/helix-loop-helix (bHLH) dioxin receptor mediates signal transduction by dioxin (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin) and functions as a ligand-activated DNA binding protein directly interacting with target genes by binding to dioxin response elements.

basic region/helix-loop-helix (bHLH) dioxin receptor


Input: The alpha 2A-adrenergic receptor (alpha 2AAR) is coupled to a variety of effectors via pertussis toxin-sensitive GTP-binding proteins.

alpha 2A-adrenergic receptor

alpha 2AAR

pertussis toxin

GTP-binding proteins


Input: A sequence comparison reveals two CCAAT/enhancer binding protein (C/EBP) consensus sequences, basic DNA binding region and leucine zippers 1 and 2 (bZIP1 and bZIP2), within this region.

CCAAT/enhancer binding protein

C/EBP


Input: One of these genes, REC114, is described here, and the data confirm that REC114 is a meiosis-specific recombination gene with no detectable function in mitosis.


Input: The transactivation function of EBNA2 was also observed in the HeLa epithelial cell line, which suggests that EBV and HIV-1 infection of non-B cells may result in HIV-1 promoter activation.

HIV-1 promoter


Input: Mutation of the C/EBP binding sites in the Rous sarcoma virus long terminal repeat and gag enhancers.

C/EBP binding sites

Rous sarcoma virus long terminal repeat

gag enhancers


Input: Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation.

Nuclear protein phosphatase 2A

protein kinase A

CREB

CREB


Input: We show that IL-6 activates JRE-IL6 through an H7-sensitive pathway that does not involve protein kinase C, cyclic AMP-dependent kinase, Ca (2 +)-or calmodulin-dependent kinases, Ras, Raf-1, or NF-IL6 (C/EBP beta).

protein kinase C

cyclic AMP-dependent kinase

Ca (2 +)-or calmodulin-dependent kinases

Ras

C/EBP beta


Input: Mutation of the presumptive phosphorylated tyrosine and threonine residues of Mpk1p individually to phenylalanine and alanine, respectively, severely impaired Mpk1p function.


Input: Growth factor stimulation rapidly induces a reversible change in the electrophoretic mobility of the ternary complex, accompanied by increased phosphorylation of the Elk-1 C-terminal region and by the activation of a 42 kd cellular Elk-1 kinase.

Elk-1 C-terminal region

42 kd cellular Elk-1 kinase


Input: In contrast to the situation in mammalian cells, prolonged exposure of the agonist (24 h) does not result in down regulation of the remaining 70% of the receptors.


Input: This stimulatory effect could also be elicited by c-Jun, which interacts with topo II, but not by c-Fos, which does not bind topo II in our in vitro assay.

c-Jun

topo II

c-Fos

topo II


Input: The regulation of Myf-5 and MyoD function by a cAMP-dependent pathway may partly explain how external signals generated by serum and certain peptide growth factors can be transduced to the nucleus and inhibit dominant-acting factors that are responsible for myoblast differentiation.

MyoD


Input: 16, 99-104).


Input: We have previously reported that high level human desmin expression depends on a 280-base pair muscle-specific enhancer which can function not only in myotubes, but can also activate gene expression in myoblasts.

human desmin


Input: After surgery, patients self administered one of three possible postsurgical medications, which included placebo, codeine 60 mg, and ibuprofen 400 mg, when their pain reached a moderate or severe intensity.


Input: Replacement of the wild-type 5'-regulatory region with either of the mutants' cis-acting regulatory element resulted in the anaerobic expression of active Mn-superoxide dismutase.

active Mn-superoxide dismutase


Input: The orf61 gene product, when expressed from an exogenous promoter, inhibited int-mediated integration at the chromosomal attB site.

orf61 gene product

int

chromosomal attB site


Input: Expression in established LCLs, occurring irrespective of virus producer status, was not a consequence of continued in vitro passage; thus, appropriately spliced BamHI-A transcripts could be amplified from normal B cells within 1 day of their experimental infection in vitro, along with BamHI-C/W promoter-initiated but not BamHI-F promoter-initiated mRNAs.

BamHI-A transcripts

BamHI-C/W

BamHI-F promoter-initiated mRNAs


Input: Analysis by cell surface immunofluorescence showed that the UL28 gene is not required for expression of viral glycoproteins on the surface of infected cells.

UL28 gene


Input: Furthermore, a mutant receptor (Y977F/Y989F [PLC gamma-binding sites]) could fully activate Ras, and the direct activation of protein kinase C and calcium mobilization had almost no effect on the GDP/GTP state of Ras in this cell line.

PLC gamma

Ras

protein kinase C

Ras


Input: Estrogen treatment in high doses is effective in reducing adult stature in constitutionally tall girls.


Input: Uracil DNA glycosylase catalyzes the initial step in the repair pathway that removes potentially mutagenic uracil from duplex DNA.

Uracil DNA glycosylase


Input: Current clinical trials should answer the question of which of the therapeutic options impairs quality of life less.


Input: In this report, we focus on the genetics of the region of the 17 hep syn gB gene that conferred both the syncytial and pathogenic phenotypes to 17 syn +.

17 hep syn gB gene

17 syn +


Input: Recipients with acute leukaemia in first remission or chronic myeloid leukaemia in first chronic phase were analysed as good risk, and those beyond these stages, as poor risk patients.


Input: Elledge, P.


Input: Drugs suppressed > or = 75% of the total premature ventricular contractions in all patients who had both use-dependent QRS prolongation and reverse use-dependent QT prolongation, in 79% of patients with use-dependent QRS prolongation alone, in 70% with reverse use-dependent QT prolongation alone, and in 11% with neither use-dependent QRS prolongation nor reverse use-dependent QT prolongation.


Input: Losses during the complete procedure are corrected for using radioactive estrogen conjugates during the first steps and later by adding deuterated internal standards of all compounds measured (matairesinol, enterodiol, enterolactone, daidzein, O-desmethylangolensin, equol, and genistein).


Input: The Sp1 region, however, is converted to a functionally strong TRE by the viral tat factor.

Sp1 region

viral tat factor


Input: Three group 1 patients developed CMV disease; 1 group 2 patient developed CMV hepatitis.


Input: The ability of spt2 mutations to suppress the transcriptional interference caused by the delta promoter insertion his-4-912 delta correlates with an increase in wild-type HIS4 mRNA levels.

spt2 mutations

delta promoter insertion his-4-912 delta

wild-type HIS4 mRNA


Input: Nuclear localization and protein sequence similarities suggested that the SPT2/SIN1 protein may be related to the nonhistone chromosomal protein HMG1.

nonhistone chromosomal protein HMG1


Input: The conserved ninth C-terminal heptad in thyroid hormone and retinoic acid receptors mediates diverse responses by affecting heterodimer but not homodimer formation.

retinoic acid receptors


Input: Genetic interactions between BCK2 and other pathway components suggested that BCK2 functions on a common pathway branch with PPZ1 and PPZ2.


Input: Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues.

Steroidogenic factor 1

orphan nuclear receptor

rat aromatase gene


Input: To study the functional differences between cutaneous HPV5 and HPV8 E7s and genital HPV16 E7, we cloned each of the E7 open reading frames and tested their immortalizing and transforming activities, the binding ability of their products with retinoblastoma protein (RB) and their complementation activity of a RB-nonbinding adenovirus E1A mutant.

genital HPV16 E7

retinoblastoma protein

RB

RB-nonbinding adenovirus E1A mutant


Input: The rhaB transcription start site was mapped to-24 relative to the start of translation.

rhaB transcription start site


Input: Several lines of evidence demonstrate that this growth inhibition requires active PKA subunits and cAMP: (i) this phenotype is dependent on cAMP since it is not seen in a strain lacking adenylyl cyclase activity, but the growth rate of these transformants is slower when exogenous cAMP is added; (ii) normal growth occurs when wild-type RI cDNA is replaced by a mutant RI cDNA encoding a RI protein with reduced cAMP binding; and (iii) the growth-inhibited phenotype of the transformed BL21 (DE3) cells requires soluble, active C alpha protein.

PKA subunits

adenylyl cyclase

RI

mutant RI cDNA

RI protein

C alpha protein


Input: Liu, B.


Input: BCR-ABL and v-abl oncogenes induce distinct patterns of thymic lymphoma involving different lymphocyte subsets.

BCR

ABL

v-abl oncogenes


Input: These experiments confirm that the 6-S liganded form of the receptor identified in nuclear extracts of cells treated with 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) contains the Ah receptor protein and ARNT but not the 90-kDa heat shock protein.

Ah receptor protein

ARNT

90-kDa heat shock protein


Input: LDL cholesterol decreased from 4. 74 +/-0. 87 to 3. 78 +/-0. 78 mmol/l after 8 weeks on simvastatin (P < 0. 001), and apo B fell from 142 +/-31 to 112 +/-22 mg/dl (P < 0. 001).

LDL cholesterol

apo B


Input: LDL cholesterol decreased from 4. 74 +/-0. 87 to 3. 78 +/-0. 78 mmol/l after 8 weeks on simvastatin (P < 0. 001), and apo B fell from 142 +/-31 to 112 +/-22 mg/dl (P < 0. 001).

LDL cholesterol

apo B


Input: This negative element may, at least in part, be responsible for the cell type-specific expression of the DGK gene.

DGK gene


Input: Regulated activity of the distal promoter-like element of the human corticotropin-releasing hormone gene and secondary structural features of its corresponding transcripts.

human corticotropin-releasing hormone gene


Input: A new bioencapsulation technology for microbial inoculants.


Input: We linked hypersensitivity site 2 (HS2) from the locus control region (LCR) to a A gamma-globin gene (A gamma *) mutationally marked to allow its transcript to be distinguished from endogenous gamma-globin mRNA.

A gamma-globin

A gamma *

gamma-globin


Input: INTERVENTIONS--Patients allocated to treatment with levodopa/dopa decarboxylase inhibitor alone (arm 1), levodopa/decarboxylase inhibitor/selegiline in combination (arm 2), or bromocriptine (arm 3).

levodopa/dopa decarboxylase

levodopa/decarboxylase


Input: It contains three putative binding sites for transcription factor Sp1 as well as several short sequences that are similar to known cis-acting enhancers or binding sites for transcription factors.

transcription factor Sp1


Input: French bean contains a small family of genes encoding PAL and two of these genes, PAL2 and PAL3, have been shown to be differentially expressed at the mRNA level in bean tissues.

genes encoding PAL


Input: Plasma thromboxane B2 levels in the older group were about double those in younger piglets.


Input: By stepwise linear multiple regression analysis, ionized magnesium was significantly related to cyclosporin trough level and total cholesterol but not to serum creatinine, time after transplant or the dose of cyclosporin.


Input: The human insulin-like growth factor II (IGF-II) gene contains four promoters (P1, P2, P3 and P4).

human insulin-like growth factor II

IGF-II


Input: Moreover, in transient transfection assays, PU. 1 alone activated reporter constructs containing the JB cis-element, and the activation was shown to be dependent on a glutamine-rich sequence in the amino-terminal portion of PU. 1.

PU. 1

PU. 1


Input: Army veterans given yellow fever vaccine contaminated with hepatitis B virus in 1942 and controls and (b) a case-control study comparing veterans with hepatocellular carcinoma in Veterans Affairs hospitals with matched controls with respect to receipt of contaminated vaccine in 1942.


Input: They were found to be seropositive for antibodies to hepatitis C virus by second-generation testing (RIBA 2, Ortho Diagnostic Systems Inc, Westwood, MA).


Input: When introduced into recJ + strains, srjA mutations conferred hyperrecombinational and hyper-UVr phenotypes.

recJ +

srjA

hyper-UVr


Input: Distinguishing roles of the membrane-cytoskeleton and cadherin mediated cell-cell adhesion in generating different Na +, K (+)-ATPase distributions in polarized epithelia.

cadherin

Na +, K (+)-ATPase


Input: Neonatal lupus erythematosus is most often associated with autoantibodies against Ro and La antigens.

Ro

La


Input: Genetic abnormalities that could lead to mutagenesis include chromosomal abnormalities and single-gene mutations.


Input: Hops, and L.


Input: Continued absorption of amino acids by the NBB carrier (for neutral amino acids), the Y + system (for dibasic amino acids), and the PHE carrier were operative even during the actively purging stage of watery diarrhoea due to cholera.


Input: 1) CFDN, AMPC and MNZ showed a potent antimicrobial activity against H. pylori, and especially, AMPC showed a marked bactericidal activity in a short time.


Input: Creutzfeldt-Jakob disease and lyophilised dura mater grafts: report of two cases.


Input: A high mean intensity of CLTPA (standardized multivariate regression coefficient beta-0. 059, p = 0. 020) and a high maximal oxygen uptake (beta-0. 163, p < 0. 001) were associated with reduced plasma fibrinogen when adjusting for the strongest covariates.

plasma fibrinogen


Input: What young people think and do when the option for cystic fibrosis carrier testing is available.


Input: A patient matches a PIC patient if both have the same mechanism of injury, the same coding of Revised Trauma Score variables (Glascow Coma Scale score, systolic blood pressure, respiratory rate), the same coded age per A Severity Characterization of Trauma) (ASCOT), and if they differ by no more than 0. 5 for A, B, and C (the ASCOT components for serious injuries).


Input: Skin and bowel TPO2 varied with DO2 and each other (P < 0. 05).


Input: We have isolated a cosmid containing DNA that corresponds to the site of transposon insertion in 257DH4 and have localized Tn5 on an 8. 0 kb EcoRI fragment.

8. 0 kb EcoRI fragment


Input: The scr regulon of pUR400 and the chromosomally encoded scr regulon of Klebsiella pneumoniae KAY2026 are both negatively controlled by a specific repressor (ScrR).

scr regulon

chromosomally encoded scr regulon of Klebsiella pneumoniae KAY2026

ScrR


Input: Although the molecular mechanisms involved in this regulation are currently being elucidated, very little is known about the trans-acting factors that allow expression of the nitrate and nitrite reductase genes which code for the first enzymes in the pathway.

nitrate and nitrite reductase genes


Input: The Ntl1 gene is present as a unique copy in the diploid N. plumbaginifolia species.

Ntl1 gene


Input: Transient transfection experiments revealed that Pax-8 isoforms a and b, but not c and d, strongly stimulate transcription from a promoter containing six copies of a paired-domain recognition sequence.

Pax-8 isoforms a and b

paired-domain recognition sequence


Input: The amino-terminal third of the protein contains a high-mobility-group motif characteristic of DNA-binding proteins.

high-mobility-group motif


Input: We have examined the ability of various NF-kappa B subunits to bind to, and activate transcription from, the IL-8 promoter.

NF-kappa B subunits

IL-8 promoter


Input: When multiple copies of the IL-1 beta NF-kappa B site were linked to an enhancerless simian virus 40 promoter, this element was able to mediate phorbol ester-or lipopolysaccharide-inducible gene expression.

IL-1 beta NF-kappa B site

simian virus 40 promoter


Input: We found that the 3'-end-adjacent sequence CA (N) 3-10AGTNNAA, conserved in plant Pol II-specific U snRNA genes, is essential for the 3'-end formation of U2 transcripts and, similar to the vertebrate 3' box, is highly tolerant to mutation.

Pol II

U snRNA genes

U2 transcripts


Input: These results indicate that Rb protein is interacting with some component (s) of the cell cycle-regulatory machinery during G2 phase.

Rb protein


Input: MDBP from HeLa and Raji cells formed DNA-protein complexes with X-box oligonucleotides that coelectrophoresed with those containing standard MDBP sites.

MDBP

MDBP sites


Input: Transgenic mice harboring the rat TnI-CAT fusion gene expressed the reporter specifically in the skeletal muscle.

TnI

CAT


Input: The ADP-ribosylation factor (ARF) family is one of four subfamilies of the RAS superfamily of low molecular weight GTP-binding proteins (G proteins).

ADP-ribosylation factor

ARF

RAS superfamily

low molecular weight GTP-binding proteins

G proteins


Input: The E1 gene is located within the first intron of the gene for RCC1, a protein that regulates onset of mitosis.

E1 gene


Input: Genomic Southern blot analysis and chromosome mapping showed that GPRK6 hybridizes to two closely related genes located on chromosomes 5 and 13 and are, therefore, distinct from the GPRK located near the Huntington disease locus on chromosome 4.

GPRK

Huntington disease locus


Input: Metabolic labeling studies in S. cerevisiae and co-expression of nmt72p with several protein substrates of Nmt1p in Escherichia coli indicate that the Leu99--> Pro substitution causes a reduction in the acylation of some but not all protein substrates.


Input: These CTD kinases, designated CTDK1 and CTDK2, are fractionated by chromatography on Mono Q.

CTD kinases


Input: Previously, we identified a 51-bp promoter fragment, oligo31/32, which conferred heat shock inducibility on the heterologous CYC1-lacZ reporter gene in S. cerevisiae (N.

lacZ


Input: To identify factors that may modify the heterosexual transmission of human T cell leukemia/lymphoma virus type I (HTLV-I), 534 married couples enrolled in the Miyazaki Cohort Study between November 1984 and April 1989 were studied: 95 husband HTLV-I-seropositive (H +)/wife seropositive (W +), 33 H +/W-, 64 H-/W +, and 342 H-/W-.


Input: To characterize the expression of this DNA repair enzyme, we have isolated the corresponding genomic clone.

DNA repair enzyme


Input: L., Stange, G., Markovich, D., Biber, J., Testar, X., Zorzano, A., Palacin, M., and Murer, H.


Input: The nucleotide sequence of the gene predicts a polypeptide of 215 amino acids (25. 2 kDa) with two putative membrane-spanning domains.


Input: SAECG, echocardiography and thallium-201 imaging were performed before and 1 month after attempted angioplasty.


Input: They were called PACE4 and PC4.


Input: Both fusion proteins form stable specific complexes with a short DNA duplex harboring the CTGT (at) 4ACAG consensus sequence of the LexA repressor.

LexA repressor


Input: Ten selenocysteine residues (deduced) are present.


Input: CONCLUSIONS: Free protein S deficiency is common among hospitalized patients, even in the absence of a recognized predisposing condition.

protein S


Input: During the past decade, different types of endogenous retroviral sequences have been defined in the human genome usually by low stringency hybridization employing DNA probes of evolutionary conserved animal retrovirus genes.


Input: As the components of these complexes, at least five TRBPs (p30, p37, p46, p50, and p56) showing specific binding to the TAR RNA were detected in the uv cross-linking assay.

TRBPs


Input: The obvious functional necessity for editing in kinetoplastid mitochondria is the formation of translatable mRNAs.


Input: An extensive inverted repeat is present 3' of rpeA; inverted repeats are found downstream of all PE operons sequenced to date, although the sequence is not conserved.

rpeA

PE operons


Input: Large differences between the groups were not observed in HA-synthesizing enzyme activity, but degradative enzyme activity was much higher in aspirin-induced asthma-related polyps than in other types of nasal polyps tested.

HA-synthesizing enzyme


Input: In the multivariate analysis, six variables were independently correlated with survival: blood urea nitrogen level, serum aspartate aminotransferase level, community-acquired vs. hospital-acquired peritonitis, age, Child-Pugh score and ileus.

serum aspartate aminotransferase


Input: Localization of the intronless gene coding for calmodulin-like protein CLP to human chromosome 10p13-ter.

calmodulin-like protein CLP


Input: In wandering stage larvae, the OBP transcript appeared to be at least 250-fold less abundant than ribosomal RNA.

OBP transcript


Input: One such mutant also affects the overlapping-10 hexamer of PR and results in reduced occupancy by both MerR and RNA polymerase, likely as a result of inefficient transcriptional initiation of merR mRNA.

MerR

RNA polymerase

merR mRNA


Input: This promoter could direct the constitutive expression of the reporter beta-galactosidase at high frequency in transfected colonies of transformed cells that express L-plastin constitutively; by contrast, this promoter was virtually inactive in transfected colonies of normal fibroblasts and it exhibited a low frequency of constitutive activation in transfected colonies of in vitro SV40-transformed fibroblasts which did not exhibit L-plastin expression.

beta-galactosidase

L-plastin

L-plastin


Input: The half-life of the serum-induced CBP/tk binding activity was estimated to be less than 1 h. (ABSTRACT TRUNCATED AT 400 WORDS)

CBP

tk


Input: The gene includes three exons and two introns within 1. 6 kilobases of DNA, and the entire open reading frame for glycoprotein IX is included within the third exon.

glycoprotein IX


Input: Rhizobium meliloti large plasmid pRmeGR4b carries the nodulation competitiveness locus nfe responsible for the nodulation efficiency and competitive ability of strain GR4 on alfalfa roots.

nfe


Input: Further, the ability of recombinant beta and/or gamma chains to function in defined biochemical assays of beta gamma activity was assessed for membrane extracts and supernatant fractions from infected Sf9 cells.


Input: This report describes the identification of a gene of related function, SMD1, located immediately 3' to PRP38.


Input: These data establish Smd1p as a required component of the cellular splicing apparatus and a factor in snRNA maturation and stability.


Input: This study compared the gross and fine motor performance of 14 traumatically brain-injured children (five to 15 years old, with loss of consciousness for at least 24 hours) to 14 normal children group matched for age and sex.


Input: We compared the parameters pleural adenosine deaminase (PADA, determined in 405 patients), the PADA/serum ADA ratio (P/SADA; 276 cases), pleural lysozyme (PLYS, 276 cases), the PLYS/serum LYS ratio (P/SLYS; 276 cases), and pleural interferon gamma (IFN, 145 cases) regarding their ability to differentiate tuberculous pleural effusions from others.

pleural adenosine deaminase

PADA

PADA

serum ADA

P

SADA

pleural lysozyme

PLYS

PLYS

serum LYS

P

SLYS

pleural interferon gamma

IFN


Input: These exons were identified by cloning and sequencing cDNAs obtained by polymerase chain reaction amplification of a fibroblast cDNA library.


Input: Deletion of the apeA gene, either with or without deletion of other proteinases (protease IV and aminopeptidase N), did not have any effect on cell growth in the various media tested.

apeA gene

protease IV

aminopeptidase N


Input: In Experiment 2 scopolamine hydrobromide, 0. 5 and 1. 0 mg/kg i. p., was administered 1 h before each electrical stimulation until each rat showed the stage-3 seizure.


Input: PNT, ADD and BSS in the initial stage of kindling, kindling rate for the stage-3 and-5 seizures, seizure parameters at the first stage-3 and-5 were recorded and compared to the values of saline-treated, control group.


Input: CONCLUSIONS.


Input: There was a positive correlation between pyridinium cross-link excretion and thyroid hormone concentrations.


Input: Mutations truncating as many as 143 C-terminal residues from the transcriptional activator encoded by the areA gene, mediating nitrogen metabolite repression in Aspergillus nidulans, do not significantly reduce the ability of the areA product to activate expression of most genes under areA control.

areA gene

areA product

areA


Input: A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis.

adenovirus 2/5 E1a protein

ras


Input: These studies demonstrate that both G alpha i genes are dynamically regulated in LLC-PK1 cells by both growth, differentiation, and hormone signals.

G alpha i genes


Input: Constructs containing the full-length PfCPK cDNA have been expressed in Escherichia coli at a high level to generate a 60-kDa recombinant protein.

full-length PfCPK cDNA


Input: In mitogen-stimulated splenocytes, Gfi-1 expression begins to rise at 12 h after stimulation and reaches very high levels after 50 h, suggesting that it may be functionally involved in events occurring after the interaction of IL-2 with its receptor, perhaps during the transition from the G1 to the S phase of the cell cycle.


Input: We have isolated and characterized the GCD6 and GCD7 genes and shown that their products are required to repress GCN4 translation under nonstarvation conditions.

GCD7 genes


Input: The plateau MO2 value was that predicted by allometric relation.


Input: While the latter corresponded to a protein of 824 amino acids, an upstream open reading frame (uORF) within the 5' leader could potentially encode a 54 amino acid peptide.


Input: The SCH9 protein kinase mRNA contains a long 5' leader with a small open reading frame.

SCH9 protein kinase mRNA


Input: In contrast to T cells, in fibroblasts PILOT gene expression requires only one signal (PMA) and is not affected by CyA.

PILOT gene


Input: Histochemical localization of GUS revealed promoter function in leaf epidermis, mesophyll and vascular bundles, in the cortex and vascular cylinder of the root.

GUS


Input: In order to investigate how these expression patterns are established, we fused promoter regions of an acidic and a basic glucanase gene to the beta-glucuronidase (GUS) reporter gene and examined expression of these constructs in transgenic tobacco plants.

glucanase gene

beta-glucuronidase

GUS


Input: Sudomoina, A.


Input: Zinc fingers (Zf) are a common structural motif found in many nucleic acid-binding proteins.


Input: The deduced bovine EFIA #1 amino acid (aa) sequence is 98% identical to rat EFIA and 100% identical to human EFIA/DbpB/YB-1 family member DNA-binding protein B (DbpB).

EFIA #1

EFIA

EFIA

DbpB

DNA-binding protein B

DbpB


Input: Effect of tracheal insufflation of deferoxamine on acute ozone toxicity in rats.


Input: Localization of the insertion locus in the yeast genome and complementation studies with the temperature-sensitive mutant indicate that the two mutations are allelic.


Input: Replacement of the spacer sequence between the two ARMs with a shorter stretch of sequence also reduced RNA binding in vitro.


Input: Second, the transcription factor Gal-ER was rendered more potent and less susceptible to cell type-specific variation by fusing the strong activating domain of the herpesvirus protein VP16 onto its C terminus.

transcription factor Gal-ER

herpesvirus protein VP16


Input: The exogenous fos gene was rapidly induced to maximal levels within 1-2 hr of estrogen addition.

fos gene


Input: Elimination of Haemophilus influenzae type b meningitis after introduction of vaccination


Input: Endosonography accurately assessed tumor extension in two T2 tumors, 14 T3 tumors, and seven T4 tumors.


Input: Analysis of cell cycle regulation in the budding yeast Saccharomyces cerevisiae has shown that a central regulatory protein kinase, Cdc28, undergoes changes in activity through the cell cycle by associating with distinct groups of cyclins that accumulate at different times.

cyclins


Input: Overlapping clones representing full-length cDNAs for MMI alpha were obtained from mouse brain.

MMI alpha


Input: The method involves preliminary isolation of oxiracetam and internal standard from plasma by solid-phase extraction prior to the formation of their n-propyl carbamate derivatives.


Input: Pathways linking the olfactory bulbs with the medial preoptic anterior hypothalamus are important for intermale aggression in mice.


Input: In contrast, rats receiving U74500A (2 mg/kg i. v. infusion commencing 30 min prior to revascularisation) exhibited enhanced GMBF throughout reperfusion [PI 10 min: 3. 26 (2. 56-3. 63); 120 min: 2. 03 (1. 73-2. 25); 240 min: 2. 13 (1. 75-2. 44), p < 0. 01 vs. controls and normals] with complete muscle salvage [GMV 100% in all reperfused muscles, p < 0. 01 vs. controls, not significant (NS) vs. normals and 6 h ischaemia]. (ABSTRACT TRUNCATED AT 250 WORDS)


Input: Sequencing of a 1. 3-kilobase fragment of the 5'-flanking region of the TSG6 gene identified TATA-like and CAAT sequences near the transcription start site.

TSG6 gene


Input: The region that imparts inducibility by IL-1 or TNF (positions-165 to-58) contains potential binding sites for IRF-1 and-2, AP-1, and NF-IL-6.

TNF

IRF-1 and-2


Input: Ig-alpha and Ig-beta contain extended cytoplasmic structure (61 and 48 amino acids, respectively) and associate with cytoplasmic effectors indicating that they are directly involved in signal transduction.

Ig-alpha

Ig-beta


Input: We studied the functional interaction between human embryonic zeta 2 globin promoter and the alpha globin regulatory element (HS-40) located 40 kb upstream of the zeta 2 globin gene.

zeta 2 globin

alpha globin regulatory element

zeta 2 globin gene


Input: It was shown by transient expression assay that HS-40 behaved as an authentic enhancer for high-level zeta 2 globin promoter activity in K562 cells, an erythroid cell line of embryonic and/or fetal origin.

zeta 2 globin promoter


Input: Initial results indicate that this 23S pre-rRNA is the same as the species detected on depletion of the small nucleolar RNA-associated proteins NOP1 and GAR1 and in an snr10 mutant strain.

23S pre-rRNA

small nucleolar RNA-associated proteins NOP1

snr10 mutant


Input: Breitbart, L.


Input: This study evaluates the feasibility of indirect mesenteric lymphangiography as a colonoscopic technique in a canine model.


Input: Internal amino acid sequence has now been obtained from this protein which shares 50-100% sequence identity with sequences encoded by mammalian G alpha 11 and G alpha q cDNAs.

mammalian G alpha 11

G alpha q cDNAs


Input: Estradiol is known to induce expression of certain proto-oncogenes, and this led us to examine potential regulatory regions of the cellular c-fos oncogene.

cellular c-fos oncogene


Input: Air lead was not a significant explanatory variable.


Input: We now show that regulation of flaN transcription in vivo depends on a sigma 54 promoter and two ftr elements located downstream of the transcription start site at + 86 (ftr2) and + 120 (ftr3).

flaN

sigma 54 promoter


Input: Fibular dimelia with deficiency of the tibia.


Input: This prospective study compared the measured energy expenditures of 30 patients using indirect calorimetry with their predicted basal energy expenditure according to the Harris-Benedict equation, or their calculated energy expenditure derived from basal energy expenditure times, an activity factor, and a stress factor.


Input: However, after repeated infections, hypobiotic larvae were numerous.


Input: This was performed in a double blinded, randomized, placebo-controlled study.


Input: Group I consisted of six noncholestatic patients; group II consisted of nine mildly cholestatic patients with mild hepatic impairment (conjugated bilirubin, 47 mumol liter-1; alkaline phosphatase, 280 IU liter-1; gamma-glutamyltranspeptidase, 190 IU liter-1); group III consisted of six benign intrahepatic cholestatic patients with high isolated conjugated hyperbilirubinemia (98. 1 mumol liter-1).

alkaline phosphatase

gamma-glutamyltranspeptidase


Input: There was either no change or an improvement in renographic findings (t1/2 time and/or split function) in 40 patients (93%).


Input: We discuss the need to use animals older than 3 months for the study of' adult' regeneration phenomena since 3-month-old rats may be somewhat immature.


Input: Nuclear beta II PKC, like p34cdc2 kinase, may function to regulate nuclear lamina structural stability during cell cycle.

Nuclear beta II PKC

p34cdc2 kinase


Input: In situ copper-phenanthroline footprinting of individual gel shift assembly intermediates shows that on the 302-nucleotide G4oric, the first two SSB tetramers assemble at random, but the addition of more SSB tetramers results in formation of a unique structure.

SSB tetramers

SSB tetramers


Input: Effects of intramammary endotoxin infusion on milking-induced oxytocin release.

oxytocin


Input: A rat cDNA that encodes eIF-5 has been isolated and expressed in Escherichia coli to yield a catalytically active eIF-5 protein.

eIF-5 protein


Input: In F42A-stimulated internalization assays on forskolin-induced YT-1 cells, the IL-2R alpha chain is consistently endocytosed together with the IL-2R beta subunit indicating that IL-2R alpha is stably associated with the F42A-IL-2R beta complex even though the alpha-subunit contributes little if any affinity to the F42A binding reaction.

IL-2R alpha chain

IL-2R beta subunit

IL-2R alpha

F42A-IL-2R beta complex


Input: The microcirculatory dynamics of prostaglandin E1 and/or nicardipine and their different reactions in the hyper-and hypodynamic state of septic shock in a rat model


Input: The short-term synthesis and infant-regulated removal of milk in lactating women.


Input: Based on these results, a new model for the regulation of nif/fix gene expression in A. caulinodans is proposed.

nif

fix


Input: Nitric oxide inhalation selectively reduces pulmonary hypertension in porcine endotoxin shock and improves arterial oxygenation and pH with a marked attenuation of sympathetic activation.


Input: B cell-specific mb-1 and B29 genes encode the alpha/beta components of the BCR-associated complex in mature sIgM + B cells.

B29 genes

BCR-associated complex

sIgM +


Input: Bipolarity in Jungian type theory and the Myers-Briggs Type Indicator.


Input: A variety of nuclear ribonucleoproteins are believed to associate directly with nascent RNA polymerase II transcripts and remain associated during subsequent nuclear RNA processing reactions, including pre-mRNA polyadenylation and splicing as well as nucleocytoplasmic mRNA transport.

RNA polymerase II transcripts


Input: Mutations at three sites have larger effects in muscle than nonmuscle cells; an A/T-rich site mutation has a pronounced effect in both striated muscle types, mutations at the MEF1 (Right E-box) site are relatively specific to expression in skeletal muscle, and mutations at the CArG site are relatively specific to expression in cardiac muscle.

MEF1 (Right E-box) site


Input: Transient transfection analysis with these mutations revealed that only a 10-bp region, containing precisely the Ets and proximal LyF-1 binding sites, was needed for D' activity.

Ets

LyF-1 binding sites


Input: However, despite its relationship to the TR, Rev-Erb bound poorly to TR binding sites.

TR

Rev

Erb

TR binding sites


Input: We report here that a 25-bp promoter element previously shown to be important for the G1-S activation of the human thymidine kinase (htk) promoter in growth-stimulated cells is a cellular target of cyclin A and the p33cdk2 complexes.

human thymidine kinase

htk

cyclin A

p33cdk2 complexes


Input: These protective influences were observed throughout the range of filling pressures measured, from 0 to 30 mmHg.


Input: DNase I footprinting with rat liver nuclear extracts identified 7 major protein-binding domains termed P1 through P7 in a 796 base pair DNA fragment (base pairs-763 to + 33).

DNase I


Input: Neither clone encoded the cognate endonuclease.


Input: The nifJ and nifH promoters of Klebsiella pneumoniae are divergently transcribed sigma 54-dependent promoters that are positively activated by the NifA protein.

nifJ

nifH promoters of Klebsiella pneumoniae

sigma 54-dependent promoters

NifA protein


Input: Both inhaled and superfused isoflurane dilated the baseline vein diameter before stimulation.


Input: Prevalence of rheumatoid arthritis and rheumatoid factor in women: evidence for a secular decline.

rheumatoid factor


Input: Although olfactory associative conditioning in newborn rats produces marked structural and functional changes in the olfactory bulb, recent evidence suggests that extrabulbar circuits must be involved in storing these early memories.


Input: The fission yeast dsk1 + gene, a multicopy suppressor for cold-sensitive dis1 mutants, encodes a novel 61-kd protein kinase.

fission yeast dsk1 + gene

dis1 mutants


Input: Closure of the patent ductus arteriosus with a Ligaclip through a minithoracotomy.


Input: Sequence comparison between the translated ORF and a protein database reveal between 26. 5 and 23. 4% aa sequence homology to bacterial transmembrane (TM) proteins including those mediating chloramphenicol (Cm) and tetracycline (Tc) resistance and an arabinose-proton symport protein.

bacterial transmembrane (TM) proteins


Input: The strategies by which hepatitis B and hepatitis D can be diminished and eventually eliminated are: immunization, measures to prevent exposure to infective blood or blood derivatives and education (in particular awareness that hepatitis B is a sexually transmitted disease).


Input: The technical construction of the mouth protectors is illustrated, as is the need for instrumentation and its costs and the materials required to manufacture these mouth protectors.


Input: Three patients had well-, 6 patients had moderately-, and 5 patients had poorly-differentiated adenocarcinoma of the prostate.


Input: Spontaneous burst firing in cat primary auditory cortex: age and depth dependence and its effect on neural interaction measures.


Input: By applying the potentiometric method, in aqueous medium of ionic strength mu = 0. 2, the stability constants, log beta 1 = 4. 42 and log beta 2 = 8. 57 were obtained.


Input: Cryopreservation straws filled with media plus additive are emersed below the surface of an unprocessed donor ejaculate.


Input: The bcl-2 gene can potentially encode 26-and 22-kDa proteins that differ only in their carboxyl tails because of an alternative splicing mechanism.

bcl-2 gene


Input: The active open reading frame in the clone maps at 27 min on the E. coli chromosome and is identical in sequence to a wild type counterpart.


Input: Subsequent cloning and nucleotide sequence analysis of the S. pombe adenylate kinase gene, adk1, revealed a coding region of 660 nucleotides.

S. pombe adenylate kinase gene


Input: As a result of alternative splicing, the BGP gene is transcribed into at least seven distinct mRNA species.

BGP gene


Input: However, essential contrast differences existing between the FSE sequences and their routine asymmetric dual SE counterpart can be identified.


Input: The level of the SUP4A53T61 transcript was threefold higher in the tap1-1 mutant than in the wild type.

SUP4A53T61 transcript

tap1-1 mutant


Input: This sequence similarity raises the possibility that GCN1 interacts with ribosomes or tRNA molecules and functions in conjunction with GCN2 in monitoring uncharged tRNA levels during the process of translation elongation.


Input: NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3' alpha enhancer at early stages of B-cell differentiation.

NF-HB

BSAP

murine immunoglobulin heavy-chain 3' alpha enhancer


Input: In conclusion, changes in carotid sinus stimulation alters blood flow to the hindlimb through changes in both Pcrit and Ra.


Input: Multizone PRK has been suggested to increase the predictability of higher myopic corrections.


Input: In 17 patients with deletions, the parental origin of deletion was determined.


Input: The COL7A1 gene, which encodes type VII collagen, has been implicated as a candidate gene for dominantly and recessively inherited forms of dystrophic epidermolysis bullosa.

COL7A1 gene

type VII collagen


Input: However, study of the productive gamma gene showed that the skipped variable exon was bounded by normal splicing signals and that the adjacent intron organization was not altered.


Input: We conclude that grade III BGCT can be treated by modified intralesional excision provided the articular surfaces and part of the metaphysis are intact.


Input: Second, nitrate induction of aeg-46. 5 operon expression is substantially enhanced in narL null strains (M. H.

aeg-46. 5 operon

narL


Input: This new knowledge has contributed to the development of a successful immunoprophylactic strategy for eliminating Hib disease.


Input: The HMG CoA reductase inhibitors are the most effective cholesterol-lowering agents currently available.

HMG CoA reductase


Input: The etiology, pathology, brain CT scan features, clinical manifestations and treatment of these accidents were discussed.


Input: Drosophila 230-kD TFIID subunit, a functional homolog of the human cell cycle gene product, negatively regulates DNA binding of the TATA box-binding subunit of TFIID.

TFIID

TATA box-binding subunit of TFIID


Input: One enigmatic aspect of GATA factor expression is that several GATA proteins, which ostensibly share the same DNA-binding site specificity, are coexpressed in erythroid cells.

GATA factor

GATA proteins


Input: Pit-1 is a tissue-specific POU domain factor obligatory for the appearance of three cell phenotypes in the anterior pituitary gland.

POU domain factor


Input: Maximum number of strains (39. 1%) were resistant in S. bareilly serotype, followed by S. typhimurium (21. 7%) and least in S. typhi (17. 4%).


Input: Characterization and hormonal regulation of the promoter of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells.

rat prostaglandin endoperoxide synthase 2 gene


Input: The retention of 75SeHCAT was low.


Input: Members of the C/EBP family of basic-leucine zipper (bZip) transcription factors form heterodimers and bind to the CAAT box and other sequence-related enhancer motifs.

C/EBP family

basic-leucine zipper (bZip) transcription factors


Input: In mammalian cells, phosphorylation of eIF-2 alpha inhibits the activity of eIF-2B, the GDP-GTP exchange factor for eIF-2.

eIF-2 alpha

GDP-GTP exchange factor


Input: In conclusion, these observations demonstrated that stratification of acute MI patients by plasma ANF level is a useful non-invasive method for predicting prognosis and for identifying individuals at high risk of cardiac death.

ANF


Input: Analysis of the binding of Lrp to a set of circularly permuted DNA fragments from this region indicates that Lrp induces DNA bending.

Lrp

Lrp


Input: Seven out of 34 patients died, giving a mortality rate of 21%.


Input: A 36-kDa protein that was localized to the membrane fraction was detected in minicells containing plasmids with the ftsN gene, confirming that FtsN was a membrane protein.

ftsN gene

FtsN


Input: SSG1, a gene encoding a sporulation-specific 1, 3-beta-glucanase in Saccharomyces cerevisiae.

sporulation-specific 1, 3-beta-glucanase


Input: Expression of this protein in E. coli demonstrated that tyrosine was incorporated during suppression and that yeast cytoplasmic TyrRS activity was produced.

yeast cytoplasmic TyrRS


Input: The first involved complementation of a nonphotosynthetic mutant of Chlamydomonas, CC-2341 (ac-u-g-2. 3), which has a frameshift mutation in the psaB gene, and selection of photosynthetic transformants on minimal medium.

psaB gene


Input: Against 200 strains of methicillin-resistant Staphylococcus aureus (MRSA) isolated from 1990 to 1991, minimum inhibitory concentrations (MICs) of a total of 15 antibacterial agents including arbekacin (ABK) were determined.


Input: It is reported that, at present, most of the MRSAs spreading in Japan are acceleratedly acquiring resistance to many drugs, and especially, they are developing high resistance against beta-lactams.


Input: Beg2 and Beg1 are regulated differently which may indicate variation in storage or utilization properties among the barley globulins.

barley globulins


Input: Here, we have more closely investigated transactivation of the human HSP70 promoter by Myb proteins.

human HSP70 promoter

Myb proteins


Input: We have found out that one-year-old carps are extremely sensitive to ichthiomycin in concentrations between 25-125 micrograms/dm3.


Input: RESULTS: Statistically significant differences were obtained between group I and II concerning the number of patients in whom induced atrial fibrillation with conduction by the accessory pathway and RR < or = 250 msec was found (0 vs 6, p = 0. 0045).


Input: We studied the effect of skinfold thickness on the correlation between serum total bilirubin level and transcutaneous bilirubin (TcB) readings.


Input: The GTPase activity of CDC42Ce is moderately stimulated by human n-chimaerin, a GTPase-activating protein for the related p21 rac1.

GTPase

human n-chimaerin

GTPase-activating protein

p21 rac1


Input: Tl-201 uptake ratio of the right ventricle, which represents the ratio of total counts of the right ventricle to counts of the administered dose of Tl-201, was higher in COPD, especially in pulmonary emphysema and B type COPD by Burrows classification than in controls.


Input: A second hydrophobic domain, bordered by two hydrophilic regions strongly suggests a transmembrane region.


Input: This gene spans 23 kb and is composed of five exons and four introns.


Input: The remaining RAD + cells progressed to form microcolonies (< 30 cells) containing aberrantly shaped inviable cells.

RAD +


Input: The 11; 22 chromosomal translocation specifically linked to Ewing sarcoma and primitive neuroectodermal tumor results in a chimeric molecule fusing the amino-terminal-encoding portion of the EWS gene to the carboxyl-terminal DNA-binding domain encoded by the FLI1 gene.

EWS gene

FLI1 gene


Input: These findings suggest that a range of microenvironmental conditions exist within purified water systems, leading to variable populations of bacteria.


Input: X-linked liver glycogenosis: localization and isolation of a candidate gene.


Input: This conclusion is based on the observations of the immunologic changes that characterize the acute stages of illness as well as on the demonstrated association with toxin-producing bacteria in the pharynx and gastrointestinal tract.


Input: Measurement of anti-HCV IgM antibodies with an experimental kit

anti-HCV IgM antibodies


Input: Embryo coculture system may contribute to understand the mechanisms underlying the decrease of fertility with aging.


Input: These cell lines displayed methylation of the CpG island surrounding the first exon of p16INK4A and expressed abundant levels of a nontranslated mRNA containing an alternative first exon (E1 beta), as did all other cell lines in which the p16INK4A locus was not deleted.

p16INK4A locus


Input: An immunoperoxidase reaction, PAP method, with the antiserum of Factor VIII as the primary antibody, was carried out in the endometrial biopsies to detect the Factor VIII activity in the endometrial endothelium before and after insertion of LNG-IUD-20.

immunoperoxidase

PAP

Factor VIII

Factor VIII


Input: Egd1p is homologous to human BTF3b, recently identified as the beta subunit of the heterodimeric nascent-polypeptide-associated complex (NAC) involved in ensuring signal-sequence-specific protein sorting and translocation [Wiedmann et al., Nature 370 (1994) 434-440].

human BTF3b

heterodimeric nascent-polypeptide-associated complex

NAC


Input: Purified PLB showed optimal lyase activity at pH 10. 0.

PLB

lyase


Input: The 5' flanking regions of both pelA and pelB were translationally fused to the beta-glucuronidase gene and introduced into F. solani f. sp. pisi, and beta-glucuronidase activities of the transformants were measured.

pelA

pelB

beta-glucuronidase gene

beta-glucuronidase


Input: When nifA mRNA 5' start points were mapped by primer extension, both a minor upstream transcript (s) starting 45 bp distal to the anaerobox and a major downstream transcript starting 10 bp distal to the sigma 54 box were observed.

nifA mRNA

sigma 54


Input: We failed to find these data to be useful in predicting the time of onset of initial seizures after acute ischemic stroke and recurrence.


Input: The human papillomavirus type 16 E7 protein complements adenovirus type 5 E1A amino-terminus-dependent transactivation of adenovirus type 5 early genes and increases ATF and Oct-1 DNA binding activity.

human papillomavirus type 16 E7 protein

adenovirus type 5 E1A

adenovirus type 5 early genes

ATF


Input: A chaotropic detergent, 0. 1% Nonidet P-40, also abolished the interaction, further supporting the hydrophobic nature of the interaction.


Input: Degradation of the soybean ribulose-1, 5-bisphosphate carboxylase small-subunit mRNA, SRS4, initiates with endonucleolytic cleavage.

soybean ribulose-1, 5-bisphosphate carboxylase small-subunit mRNA


Input: Cloning and sequencing revealed that dMax contains a deletion spanning the basic region and helix 1 and the loop of the helix-loop-helix region, presumably as a result of alternative splicing of max RNA.

dMax

max RNA


Input: The domain structure of bovine LTBP-2 is very similar to that of the human LTBP-2, containing 20 examples of 6-cysteine epidermal growth factor-like repeats, 16 of which have the consensus sequence for calcium binding, together with 4 examples of 8-cysteine motifs characteristic of fibrillins and LTBP-1.

bovine LTBP-2

human LTBP-2

epidermal growth factor-like repeats

fibrillins


Input: Similarly, expression of a transiently transfected wild-type prothymosin alpha gene as the reporter was not affected by a repertoire of myc-derived genes, including myc itself and dominant or recessive negative myc mutants.

wild-type prothymosin alpha gene

myc-derived genes

myc

myc mutants


Input: Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1.

alpha/beta interferon

Jak

Stat

tyrosine phosphatase SHPTP1


Input: We now report the isolation and expression of cDNAs encoding PTF gamma and PTF delta, as well as functional studies with cognate antibodies that recognize the native PTF complex in HeLa extracts.

PTF gamma

PTF delta

PTF complex


Input: Results from the mechanism study have revealed that YY1 is able to inhibit transactivation mediated by either AP1 or the Sp1-related protein, and YY1 suppressive activity is DNA binding dependent.

Sp1-related protein


Input: The skp1 + gene is not essential.

skp1 + gene


Input: The TEA1 (Ty enhancer activator) gene sequence predicts a protein of 86. 9 kDa whose N terminus contains a zinc cluster and dimerization motif typical of the Gal4-type family of DNA-binding proteins.

Ty enhancer activator

Gal4-type family


Input: Videonystagmoscopy has been used to subjectively observe the responses of the vestibular system in a population of patients with vestibular deficits.


Input: The MCA and UA PI values showed the greatest deviation for any single-vessel parameter.


Input: Stems contain distinctly less P protein mRNA and the relative level in roots is very low but still clearly detectable.

P protein mRNA


Input: The B. germanica cyclophilin amino acid sequence shares 83% identity with the cytosolic cyclophilin isoform from Drosophila melanogaster (Cyp-1).

B. germanica cyclophilin amino acid sequence

cytosolic cyclophilin isoform from Drosophila melanogaster


Input: The minimal region of overlap of Langer-Giedion syndrome deletions, previously identified by analysis of 15 patients, was placed on the map by analysis of 2 patients whose deletions define the endpoints.


Input: Comparison of promoters repressed by c-myc reveals a weak consensus sequence of the initiator (Inr) element: TCA (+ 1) YYYNY.

c-myc


Input: The human gp39 promoter.

human gp39 promoter


Input: Transfection analyses indicate that mutation of any one of these TGACCT motifs or truncation of the entire HD PPRE into a separate DR1 and DR2 element significantly reduced the transcriptional response of HD PPRE to peroxisome proliferators.

HD

HD


Input: The site of autophosphorylation is Tyr397 which corresponds to the consensus autophosphorylation site of other Src family tyrosine kinases.

Src family tyrosine kinases