Input: Through two novel mechanisms, Arf inhibits the oncoprotein Hdm2, a negative regulator of p53.

Arf

oncoprotein Hdm2


Input: In the free-swimming rotatory test mice spend most of the time swimming close to the wall of the container attempting to escape from an aversive test situation.


Input: Examination of various promoter deletion mutants indicated that SF-1 acts through the proximal promoter region and upstream promoter sequences.


Input: Prrp can also associate with the EVH1 domain of Mena, another microfilament-associated protein.

Prrp

EVH1 domain

Mena


Input: Srb10 is a physiological regulator of Gcn4 stability because both phosphorylation and turnover of Gcn4 are diminished in srb10 mutants.

srb10 mutants


Input: A new intron of 476 base pairs was found in the middle of the 5'-untranslated leader sequence and was shown to robustly enhance the promoter activity.


Input: Based on this analysis, we propose that the interactions of Sos with the switch 1 and switch 2 regions of Ras have distinct functional consequences: the interaction with switch 2 mediates the anchoring of Ras to Sos, whereas the interaction with switch 1 leads to disruption of the nucleotide-binding site and GDP dissociation.

Sos

Ras

Ras

Sos


Input: A log-linear dose-response was obtained for the average increase in FEV1 up to 6 h (AUC0-6 h) and peak FEV1 across the dose range administered by Respimat.


Input: Bandshift experiments demonstrate that BmHR3A binds specifically to RORE (Retinoic acid-related Orphan receptor Response Element)-like sequences in the promoters of both genes, thus suggesting a direct role for BmHR3A in regulating the expression of BmGATAbeta and ESP genes during vitellogenesis.

RORE

Retinoic acid-related Orphan receptor Response Element

BmGATAbeta

ESP genes


Input: This was most pronounced during the initial phase of Erk activation.

Erk


Input: The iterative method proposed by Bengtsson [Appl.


Input: The COD and color removals were both more than 90% when FeCl3 was used as the coagulation (dosages of two-step coagulation were 0. 031 and 0. 012 mol/L respectively) after a ferrous hydrogen peroxide oxidation pretreatment at a H2O2 dosage of 0. 06 mol/L.


Input: Although there was a high correlation between sap flux densities registered by the old and new sensors, significant differences in sap flux densities between the duplicated sensors were detected.


Input: Three of the proteins involved in checkpoint signaling, Rad1, Hus1, and Rad9, have been shown to interact by immunoprecipitation and yeast two-hybrid studies.


Input: Based on the hypothesis that evolutionarily conserved regions are functionally important and likely to interact with coactivators, we compared the amino acid sequence of C/EBPalpha from different species (frog to human) and identified four highly conserved regions (CR1-CR4) within the transactivation domain.

C/EBPalpha


Input: Tolerance to ADAL-2 was similar to that of Vicryl suture and tolerance to ADAL-2 was superior to that to Tisuacryl.


Input: Of the patients in each regimen who reached study end points, 17 of 29 (59%) were in regimen A, 11 of 20 (55%) were in regimen B, and 28 of 43 (65%) were in regimen C met the treatment success criterion.


Input: SAMPLE POPULATION: MCB from 7 racing Greyhounds euthanatized for reasons unrelated to MCB abnormalities.


Input: CONCLUSIONS AND CLINICAL RELEVANCE: Increased cortical thickness and geometric properties of left MCB-IV and-V of Greyhounds, together with altered turnover and orientation of osteons in the dorsal quadrants of left MCB, are site-specific adaptive responses associated with asymmetric cyclic loading as a result of racing on circular tracks.


Input: METHODS AND RESULTS: Palmaz-Schatz stents were dip-coated with paclitaxel (0, 0. 2, 15, or 187 microgram/stent) by immersion in ethanolic paclitaxel and evaporation of the solvent.


Input: Percentages of recovery for overload and dilution tests were between 87 and 120%.


Input: One of the conserved RNA subdomains, designated P3, has previously been shown to be required for nucleolar localization.


Input: In Cd-spiked OECD soil, internal Cd levels were linearly related to external Cd concentrations, whereas the springtails maintained fixed internal levels of Cu and Zn regardless of spiked concentrations.


Input: Nutritional status in adults on an alternative or traditional diet] BACKGROUND: Plant food lacks vitamin B12, vitamin D and higher n-3 polyunsaturated fatty acids.


Input: It is useful as an adjunct to mammography in those patients with radiographically dense breasts for the characterization of palpable masses.


Input: Measurements were obtained: (i) just after the traumatic exposure (D0); (ii) 3 days after this first measurement (D3); and (iii) 30 days after (D30).


Input: Changes of the DB sequence without affecting the postulated stem structure led to drastic losses of translation efficiency.


Input: It has been suggested that members of this protein family exhibit both prolyl isomerase and chaperone activity.

prolyl isomerase


Input: Inhibition of the Raf-1 target ERK kinase (MEK) either attenuated or abolished Rp-cAMPS-and PKI-induced ERK activation, caldesmon phosphorylation, and stress fiber formation.

Raf-1 target ERK kinase

MEK

PKI

ERK

caldesmon


Input: PACAP mRNA was widely expressed in most human tissues; in transfected cells, PACAP was diffusely expressed in the cytoplasm.

PACAP mRNA

PACAP


Input: The radial forearm flap is used most commonly, however the lateral arm flap may be the flap of choice in certain situations.


Input: By comparison, in nontumorigenic Ad5 cells, class I expression is high due to negligible binding of COUP-TF and strong binding of NF-kappaB.

COUP-TF

NF-kappaB


Input: As an application of reverse genetics, we introduced one nucleotide change (UCU to ACU) to immediate downstream of the RNA-editing site of the V gene in the full-length hPIV2 cDNA and were able to obtain infectious viruses [rPIV2V (-)] from the cDNA.

V gene


Input: The frameshift initiated by ADEx2 is believed to alter the regular coding sequence, acting as a loss-of-function ASIP mutation.

ASIP mutation


Input: In regards to the latter activity, it has been shown that S3 contains vigorous N-glycosylase activity for the removal of 8-oxoguanine residues in DNA that leaves baseless sites in their places.

N-glycosylase


Input: Here we report the isolation and characterization of the forkhead homologue in rhabdomyosarcoma (FKHR), a recently described member of the hepatocyte nuclear factor 3/forkhead homeotic gene family, as a nuclear hormone receptor (NR) intermediary protein.

forkhead homologue in rhabdomyosarcoma

FKHR

hepatocyte nuclear factor 3

forkhead homeotic gene family

nuclear hormone receptor

NR


Input: The improved CSF outflow conductance may increase the intracranial compliance and thereby dampen a pathological ICP waveform.


Input: A new species of Euspondylus is described based on a female (taken within a bromeliad) from Cerro El Humo, Sucre, northeastern Venezuela.


Input: The cyclins bind to and activate the CDK, which leads to phosphorylation (and then inhibition) of the tumor suppressor protein, pRb. pRb controls commitment to progress from the G1 to S phase, at least in part by repressing the activity of the E2F transcription factors known to promote cell proliferation.

cyclins

CDK

pRb

pRb

E2F transcription factors


Input: Additional education and research is needed to provide further direction for intervention and incorporation into practice.


Input: Proliferative vasculopathy and cutaneous hemorrhages in porcine neonates infected with the porcine reproductive and respiratory syndrome virus.


Input: The difference of hardness over time of composite specimens was measured using Knoop hardness measurements taken at the top and bottom surfaces of resin specimens made in a Teflon mold the same dimensions as the cavity prepared in dentin.


Input: An 18-kb genomic clone including sequences encoding for the two GHS-R variants was isolated.

GHS-R variants


Input: Saccharomyces cerevisiae activates a regulatory network called " general control " that provides the cell with sufficient amounts of protein precursors during amino acid starvation.


Input: In Ka13 cells, CoCl (2) stimulated expression of a luciferase reporter gene under the control of a 15-kilobase pair mouse ho-1 promoter (pHO15luc).

luciferase reporter gene

15-kilobase pair mouse ho-1 promoter


Input: Mutation analyses identified the cobalt-responsive sequences as the stress-response elements (StREs).


Input: Members of the AP-1 superfamily of basic-leucine zipper factors bind to the StRE.

AP-1 superfamily of basic-leucine zipper factors


Input: Descriptions of this locus would allow comparison with functionally relevant molecular genetic features of other species' homologous loci including the single-copy equid LH/CGbeta gene and the primate LHbeta-CGbeta gene cluster locus.

LH

CGbeta

LHbeta

CGbeta


Input: Like the consensus mammalian LHbeta gene, the 5'-flanking region of the gpLH/CGbeta gene contains a single TATA sequence 37 bp upstream of the translation start codon.

consensus mammalian LHbeta gene

gpLH

CGbeta


Input: This shows that in situations of separated breaks, NHEJ deficiency leads to genomic rearrangements, in agreement with chromosomal studies.


Input: Foxp1 and Foxp2 are expressed at high levels in the lung as early as E12. 5 of mouse development with Foxp2 expression restricted to the airway epithelium.


Input: Immunological and biochemical characterization of streptococcal pyrogenic exotoxins I and J (SPE-I and SPE-J) from Streptococcus pyogenes.

streptococcal pyrogenic exotoxins I and J

SPE-I

SPE-J


Input: Several dozen HIF-1 targets are known, including the gene encoding vascular endothelial growth factor (VEGF).

HIF-1 targets

vascular endothelial growth factor

VEGF


Input: We previously reported that Tax induced cell cycle progression from G0/G1 phase to S and G2/M phases in human T-cell line Kit 225 cells.

Tax


Input: Most yeast peroxisomal matrix proteins contain a type 1C-terminal peroxisomal targeting signal (PTS1) consisting of the tripeptide SKL or a conservative variant thereof.

yeast peroxisomal matrix proteins


Input: Here, the PEX5-TPR domains from human, tobacco, and nematode were inserted into a TPR-less yeast Pex5p construct to generate Pex5p chimaeras.


Input: HIV-1 and hepatitis B virus infections in adolescents lodged in security institutes of Buenos Aires.


Input: Immunofixation experiments of C4A and C4B demonstrate > 41 allotypes in the two classes of proteins.


Input: However, C4B proteins encoded by monomodular short genes may have relatively higher concentrations than those from long C4A genes.

C4B proteins

long C4A genes


Input: In the course of screening for transcription factors which interact with the human myeloperoxidase (MPO) promoter we, for the first time, identified and cloned the cDNA and genomic DNA for human HBP1 (HMG-Box containing protein 1), a member of the high mobility group of non-histone chromosomal proteins.

human myeloperoxidase

MPO

human HBP1

HMG-Box containing protein 1

high mobility group of non-histone chromosomal proteins


Input: The human protein sequence exhibits a putative DNA-binding domain similar to that seen in rat HBP1 and shows homology with the activation and repressor domains previously demonstrated in the rat protein.

rat HBP1


Input: Promoter transcriptional activity was determined for a wide 5' portion of the human annexin A5 gene, from bp-1275 to + 79 relative to the most 5' of several discrete transcription start points.

annexin A5 gene


Input: In contrast the human and mouse BCNT proteins contain one repeat unit and lack the RTE-1-derived portion.

mouse BCNT proteins


Input: Molecular identification of smg-4, required for mRNA surveillance in C. elegans.


Input: Two remotely situated exons within the complement C3 gene locus encode an alternate 5' end and proximal ORF under the control of a bidirectional promoter.

complement C3


Input: CONCLUSIONS: Adding MMF, a potent topical corticosteroid, to an emollient cream is statistically significantly more effective than emollient cream alone in reducing acute radiation dermatitis.


Input: Recent advances have shown that volatile sulfur is a result of ecological interactions and transformation processes through planktonic food webs.


Input: The first hypothesis was supported in the sense that stimulus differences might affect behaviour even without their successful attentive processing in normal participants.


Input: There was an increase in protein binding onto this element only after peptide treatment.


Input: CSR is directed to specific heavy chain isotypes by cytokines and B cell activators that induce transcription from the unrearranged, or germline (GL), C (H) region genes.

C (H) region genes


Input: In this manuscript we demonstrate that two tandem Ets sites in the mouse GL alpha promoter bind the transcription factors Elf-1 and PU. 1, and that the 3' site is essential for expression of a luciferase reporter gene driven by the GL alpha promoter.

tandem Ets sites

mouse GL alpha promoter

transcription factors Elf-1

PU. 1

luciferase reporter gene

GL alpha promoter


Input: Cell.


Input: The mean serum creatinine level did not change during the first 6 months after withdrawal of MMF.


Input: The proportion of the biopsies found to be seropositive for HBs antigen was 27. 9%, and these showed either MGN or MPGN pattern.

HBs antigen


Input: They correspond to nucleotides equivalent to base-pair C1-G72 and discriminator base A73 in the amino acid-acceptor branch of the molecule.


Input: This domain without the canonical anticodon loop or the tyrosine anticodon acts as an anchor for TyrRS interaction leading to a better efficiency of tyrosylation.

TyrRS


Input: During most of the cell cycle, separase is kept inactive by binding to an inhibitory protein called securin.

separase

securin


Input: Mechanical ventilation in control lungs produced a 47% decrease in chord compliance, an increase in lung lavage levels of tumor necrosis factor (TNF)-alpha (722 +/-306 pg/ml), interleukin (IL)-1beta (902 +/-322 pg/ml), and macrophage inflammatory protein-2 (MIP-2) (363 +/-104 pg/ml) as compared with low levels of cytokines detected in preventilation data, and no change in percentage of surfactant large aggregates (LA).

tumor necrosis factor (TNF)-alpha

interleukin (IL)-1beta

macrophage inflammatory protein-2


Input: Maternal p, p' DDE and beta-HCH levels were also associated with newborn levels, but levels of PCBs were not.


Input: Multiple regression analysis performed between these long-term abiotic factors and nymphal abundance in positive sites showed high relationship (R2 coefficients) for every habitat category and explained > 50% of the variation in tick abundance.


Input: In summary, we conclude that the adenoviral oncoprotein E1A activates transcription from the endogenous AP-2alpha gene, an effect that involves transcriptional derepression of the AP-2alpha promoter by interaction of E1A with the AP-2rep corepressor CtBP1.

AP-2alpha gene

AP-2alpha promoter


Input: Additional factors such as advanced age, concomitant use of corticosteroids or anticoagulants, prior ulcer complications and co-morbid diseases may further increase the risk of bleeding.


Input: The core promoter of human thioredoxin reductase 1: cloning, transcriptional activity, and Oct-1, Sp1, and Sp3 binding reveal a housekeeping-type promoter for the AU-rich element-regulated gene.

human thioredoxin reductase 1


Input: Here we show that phosphorylation-induced loss of the protein kinase activity of DNA-PK is restored by the addition of the purified catalytic subunit of either protein phosphatase 1 or protein phosphatase 2A (PP2A) and that this reactivation is blocked by the potent protein phosphatase inhibitor, microcystin.

DNA-PK

protein phosphatase 1

protein phosphatase 2A


Input: The first exon (exon 1A) that corresponded to the 5'-untranslated region of the GHR 1A mRNA was 15, 250 bp upstream from exon 2 in the GHR gene.

GHR 1A mRNA

GHR gene


Input: FLP and Cre recombinase function in Xenopus embryos.

FLP

Cre recombinase


Input: A method of three-station three-dimensional magnetic resonance (MR) angiography of the lower extremities with segmented volume acquisition is presented.


Input: A single nucleotide polymorphism (SNP) in exon 2, which is tightly liked to another SNP (GTG83/ATG83), creates an additional alternative in-frame AUG in B-type MTH1 mRNAs yielding the fourth MTH1 polypeptide, p26 that possesses an additional mitochondrial targeting signal.

B-type MTH1 mRNAs

MTH1 polypeptide


Input: Our previous studies have shown that SHP-1, a SH2 domain-containing protein-tyrosine phosphatase, is expressed not only in cells of hematopoietic lineages, but also in many non-hematopoietic cells under the control of an alternative tissue-specific promoter, P1.

SH2 domain-containing protein-tyrosine phosphatase


Input: Unexpectedly, Arg1-expressing COS1 cells showed no significant proteinase activity to various synthesized substrates under neutral or acidic conditions in this study.


Input: ORF1 (1029 bp; EMBL databank, Accession No.


Input: In the meantime, one has succeeded to establish the deammonification processes in a continuous flow moving-bed pilot plant.


Input: The purpose of this study was to evaluate simplified methods for estimation of Technetium Tc 99m (99mTc)-pentetate and orthoiodohippurate I 131 (131I-OIH) plasma clearance in dogs and cats with 1 and 2 blood samples.


Input: Interventions aimed at these specific mediators and processes may be successful in reducing the very significant human and economic costs of vascular access dysfunction.


Input: In addition, stonin 2 binds to the C2B domains of synaptotagmins I and II.

stonin 2

synaptotagmins I and II


Input: This partial transection could permit vasopressin to be secreted in response to a larger rise in plasma sodium concentration.

vasopressin


Input: In conclusion, USPIO-enhanced MRI data were capable to characterize tumor microvessel properties in this breast cancer model: microvascular permeability (determined using USPIO) correlated significantly with tumor grade.


Input: However, the N63S mutation in the wild-type VP5 background increased the interaction, as judged by the beta-galactosidase activity, by a factor of 9 relative to when the PR7 mutation was present.

wild-type VP5

beta-galactosidase


Input: An integrated RTC algorithm for the urban wastewater system is formulated, the parameters of which are optimized using various global optimization routines.


Input: SKP1-SnRK protein kinase interactions mediate proteasomal binding of a plant SCF ubiquitin ligase.

SnRK

SCF ubiquitin ligase


Input: PATIENTS AND METHODS: Between June 1991 and December 1996, we administered the nucleoside analog 2-chlorodeoxyadenosine (2-CDA) to 73 children with primary AML and 20 children with secondary AML or myelodysplastic syndrome (MDS).


Input: The severity of pathologic changes increased with the magnitude of percussion.


Input: Experimental study of ta chengchi tang decoction for relieving lung injury during acute necrotizing pancreatitis] The objectives of the study were to investigate the changes of leukocyte adhesiveness and tumor necrosis factor (TNF) in the early stage of acute necrotizing pancreatitis (ANP), to go further into the relation of those changes to lung injury of ANP, and to evaluate the prohibitive effect of ta chengchi tang Decoction on leukocyte adhesion and TNF secretion.

tumor necrosis factor

TNF

TNF


Input: A variety of receptor-mediated signaling pathways are controlled by both positive and negative extracellular regulators.


Input: TT cells, a human MTC cell line expressing MEN 2A type RET, display transcriptionally active RelA (p65) in the nucleus.

MEN 2A type RET

RelA (p65)


Input: Inhibition of constitutive NF-kappaB activity results in cell death of TT cells and blocks focus formation induced by oncogenic forms of RET in NIH 3T3 cells.

NF-kappaB

RET


Input: Reciprocally, HMGI-C expression also coordinately enhances PIAS3-mediated repression of STAT3-dependent transactivation.

HMGI-C


Input: A central finding is the identification of a GC-rich sequence in the-99/-91 Cp region that is essential for oriPI-EBNA1-independent as well as oriPI-EBNA1-dependent activity of the promoter.

Cp


Input: Additional deletion mutations revealed a new, 67-amino-acid functional domain within the proline-rich region of SLP-76, which we have termed the P-1 domain.


Input: Finally, profiling of a gcn4Delta mutant uncovered an alternative induction pathway operating at many Gcn4p target genes in histidine-starved cells.

gcn4Delta mutant

Gcn4p target genes


Input: Evidence from a Northern hybridization indicated that jadM expression is correlated with jadomycin B synthesis.

jadM

jadomycin B


Input: Right LHR (R-LHR) provided the best interobserver and intraobserver reproducibility.


Input: CONCLUSIONS: The methodology of LHR measurement significantly influences the clinical contribution of Tl-201 lung uptake evaluation.


Input: Mutation of the NF-kappaB site in the Mdr1b promoter prevents its induction by TNF-alpha.

NF-kappaB site

Mdr1b promoter

TNF-alpha


Input: To determine the genomic complexity of the deleted region shared among tumors, we assembled a physical map of the I Mbp SRO consisting predominantly of bacteriophage P1-derived artificial chromosome (PAC) clones.


Input: Online teaching: design and techniques.


Input: Data were obtained from 2 undergraduate student samples, a self-report group (n = 132) who provided NEO-PI-R self-ratings on 2 occasions separated by a 7-to 14-day interval and an informant group (n = 109) who provided ratings of well-known friends or relatives on 2 occasions separated by a 6 month interval.


Input: Northern blot analysis of RNAs from a number of mouse tissues reveals that Atp6i is expressed predominantly in osteoclasts, and this predominant expression was confirmed by reverse-transcription polymerase chain reaction (RT-PCR) assay and immunohistochemical analysis.


Input: Indeed, mutation of two of these motifs, known to be important to regulation of sid1, altered the differential regulation of sid2 by iron.


Input: The described results show that DTD is fast, simple, and easy to automate; requires only a small amount of sample (approximately 50 mg); and affords quantitative information about the main groups of compounds present in cheeses.


Input: Guidelines for performing a routine spiral assay are presented, and alternative test methods intended to overcome a variety of technical difficulties (such as restricted sample availability, sample viscosity or volatility, etc.) are recommended.


Input: In conclusion, obesity, alcohol intake, and multimetabolic disorders were determined to be independent predictors for the development of hyperuricemia.


Input: Autoregulation enables different pathways to control CCAAT/enhancer binding protein beta (C/EBP beta) transcription.

CCAAT/enhancer binding protein beta

C/EBP beta


Input: As a reflection of uncertainties in the estimates for individual sources, the 90th percentiles of PCDD/F releases for 1999 ranged up to 4. 1 g I-TEQ/y.


Input: Gabapentin for opiod-related myoclonus in cancer patients.


Input: CONCLUSIONS: Our meta-analysis of randomized controlled trials of HRT noted a statistically significant reduction in nonvertebral fractures.


Input: Newcastle disease antibody titre is dependent on serum calcium concentration.

Newcastle disease antibody


Input: A total of 25 patients with malignant brain tumours were investigated.


Input: Net lift and combined drag from all 8 bearings of the 4-bladed impeller are compared with predictions based on 2-D theory.


Input: Our results indicate that Gab1 is involved in the control of egr-1 expression regulated by insulin.

insulin


Input: The co-existence of TE domains within modular PKSs along with physically separated, monofunctional TEs (TE IIs) has been reported for a number of modular polyketide and non-ribosomal peptide synthases (NRPS).

TE domains

PKSs

TEs

TE IIs

non-ribosomal peptide synthases

NRPS


Input: To gain an understanding of the mGSTM2 regulation, we have also cloned and analyzed its promoter region.


Input: 10. 0 +/-2. 0 pmol/24 h, P < 0. 01) and remained elevated.


Input: SELECTION CRITERIA: All randomised controlled trials comparing IUSs with other forms of reversible contraceptives and reporting on pre-determined outcomes in women of reproductive years.


Input: OBJECTIVES: The objective of this review was to compare the effectiveness, safety and acceptability of the diaphragm with and without spermicide.


Input: To test the hypothesis that these elements are required for promoter activity, we compared the reporter expression activity of segments containing mutations of these elements with activity of the parent Hlx promoter sequence.

parent Hlx promoter sequence


Input: In all of these cases, expression of the implicated genes was absent.


Input: CONCLUSIONS: Ketamine-induced dissociative anesthesia produces persistently elevated BIS index which is different from thiamylal and those reported with other conventional anesthetic agents.


Input: Our results are reassuring and we therefore advise that in patients undergoing free jejunum flap reconstruction of the hypopharyngo-esophageal tract voice restoration should be attempted by placing a voice prosthesis through a secondary tracheo-esophageal puncture and providing intensive speech training.


Input: Hypercalcemia associated with elevated serum PTH concentration indicating primary hyperparathyroidism was found in 7 BC patients (7%) and in none of healthy women or patients with thyroid cancer.

serum PTH


Input: Positive and significant correlations were found between the weeks of pregnancy and Se levels in kidney (r = 0. 433, P = 0. 023) and heart (r = 0. 313, P = 0. 030).


Input: This study suggests that PSP is more common than previously considered, is commonly misdiagnosed and that the majority of cases are not initially referred to neurologists.


Input: In Saccharomyces cerevisiae, entry into mitosis requires activation of the cyclin-dependent kinase Cdc28 in its cyclin B (Clb)-associated form.

cyclin-dependent kinase Cdc28

cyclin B

Clb


Input: We investigated the production of hyaluronan (HA) and its effect on cell motility in cells expressing the v-src mutants.

v-src mutants


Input: Our results indicate that D (4) and D (2L) receptors activate the ERK kinase cascade by first mobilizing signaling by the PDGF receptor, followed by the subsequent activation of ERK1/2 by pathways associated with this receptor tyrosine kinase.

ERK kinase

PDGF receptor

receptor tyrosine kinase


Input: Karger AG, Basel


Input: NIRS was used for the quantitative measurement of muscle O (2) consumption (mV. O (2)) and forearm blood flow (FBF) in 78 healthy subjects.


Input: No dominant clinical factor of risk was found, but multiple regression analysis identified age, body surface area, valve size, shop order fracture rate, and manufacturing period as risk factors for OSF.


Input: In this report this technique was applied to human breast carcinoma MDA-MB231 cells overexpressing human MPG in order to assess whether up-regulation of the initial step in BER alters the activity of selected other BER (hOGG1 and APE/ref-1) or direct reversal (MGMT) repair activities.

human MPG

APE

MGMT


Input: The selective alteration of the genome using Cre recombinase to target the rearrangement of genes flanked by LOX recognition sequences has required the use of two separate genetic constructs in trans, one containing cre and the other containing the gene of interest flanked by LOX sites.

Cre recombinase

LOX recognition sequences

LOX sites


Input: Influence of compression therapy on symptoms following soft tissue injury from maximal eccentric exercise.


Input: Keratoconjunctivitis sicca appears to be a common ocular complication and all children with JRA should be screened for it with a comprehensive battery of tests.


Input: STAT5A mutations in the Src homology 2 (SH2) and SH3 domains did not alter the BTK-mediated tyrosine phosphorylation.

Src homology 2

SH3 domains

BTK


Input: In conclusion, primary chemotherapy based on high dose MTX and ara-C is highly efficient in PCNSL.


Input: Reovirus mRNAs are efficiently translated within host cells despite the absence of 3' polyadenylated tails.


Input: Analyses revealed that scale matters above and beyond the effect of quadrat area.


Input: Myasthenia gravis is an autoimmune disease resulting from the production of antibodies against the ACh receptors of the neuromuscular synapse.

ACh receptors


Input: Copyright 2001 Academic Press.


Input: Using the postural and force data as input to a 3-D biomechanical model, the lumbosacral spinal compression was calculated.


Input: Angina (Q) persistence showed marked associations with previous myocardial infarction, diagnosed angina, electrocardiogram ischemia, and subsequent major ischemic heart disease events from Q5 onward.


Input: In the past decade, there have been enormous advances in the use of Bayesian methodology for analysis of epidemiologic data, and there are now many practical advantages to the Bayesian approach.


Input: To assess more specific PKA-dependent mediation of LH' s contribution to combined hormonal drive, the LDL receptor (-1076 to + 11 bp) reporter plasmid was cotransfected with a full-sequence rabbit muscle protein kinase inhibitor (PKI) minigene driven constitutively by a Rous sarcoma virus promoter.

PKA

LH' s

LDL receptor (-1076 to + 11 bp) reporter

full-sequence rabbit muscle protein kinase inhibitor

PKI

Rous sarcoma virus promoter


Input: To investigate the convergent role of the insulin/IGF-I effector pathway mediating bihormonal stimulation of LDL receptor promoter expression, transfected granulosa-luteal cells were pretreated for 30 min with two specific inhibitors of phophatidylinositol 3-kinase, wortmannin (100 nM) and LY 294002 (10 microM), or of mitogen-activated protein kinase kinase, PD 98059 (50 microM), U0126 (10 microM), or the latter' s inactive derivative, U0124 (10 microM).

insulin

IGF-I

LDL receptor promoter

phophatidylinositol 3-kinase

mitogen-activated protein kinase kinase


Input: Concerted transcriptional activation of the low density lipoprotein receptor gene by insulin and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase a, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase signaling pathways.

low density lipoprotein receptor gene

insulin

luteinizing hormone

protein kinase a

phosphatidylinositol 3-kinase

mitogen-activated protein kinase


Input: These studies demonstrate that site-specific recognition of the bxd PRE by d (GA) (n) repeat binding activities mediates PcG-dependent silencing.

bxd PRE

PcG


Input: Our findings further our understanding of how ZBP-89 modulates cell proliferation and reveals a novel mechanism by which the p53 protein is stabilized.

p53 protein


Input: A computerized method of determining the focal point of electrical activity in the pallidum of parkinsonian patients was developed using on-line quantitative physiological data analysis.


Input: Isolated Systolic Hypertension: An Update.


Input: The N-terminal portion of Notch (IC) inhibited p50 DNA binding and interacted specifically with p50 subunit, not p65 of NF-kappaB.

Notch (IC)

p50 subunit

NF-kappaB


Input: Conformational changes of the ferric uptake regulation protein upon metal activation and DNA binding; first evidence of structural homologies with the diphtheria toxin repressor.

ferric uptake regulation protein

diphtheria toxin repressor


Input: As a complement to genome-wide mapping and sequencing efforts, it is often important to generate detailed maps and sequence data for specific regions of interest.


Input: Granulocyte colony-stimulating factor (G-CSF) administration in vivo has been shown to improve the defence mechanisms against infection by different microbes.

Granulocyte colony-stimulating factor

G-CSF


Input: Among individuals, however, changes were strongly correlated with ACR levels at baseline.


Input: Thus, the screen for toxic p53 mutants in yeast can identify novel p53 variants that may be useful in dissecting p53 regulated cellular responses and in developing p53-based cancer therapies.

p53 mutants


Input: This is necessary if psychiatric diagnoses are ultimately going to be refined and validated against biological criteria.


Input: Since the latter is very small for physiological flows, the result is that alpha < 1 even at relatively high values of the Reynolds number (i. e., for non-negligible inertia) and we validate our perturbation theory results by comparison with a numerical integration of the full model.


Input: Cells lacking p116 exhibit a striking defect in the formation of these macropinocytic structures, a concomitant reduction in the rate of fluid phase pinocytosis, a significant decrease in the efficiency of chemotactic aggregation, and a decrease in cellular F-actin content.

F-actin


Input: The validity of the FPS-R was further supported by strong positive correlations with the VAS (r = 0. 92, N = 45) and the CAS (r = 0. 84, N = 45) in this clinical sample.


Input: The susceptibility of Aspergillus fumigatus to mulundocandin, an echinocandin-like compound, and other antifungal agents was assessed by the National Committee for Clinical Laboratory Standards (NCCLS) M38-P method, a 2, 3-bis (2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenyl-amino) carbonyl]-2H-tetrazolium hydroxide (XTT)-based colorimetric assay, and determination of morphologic alterations by microscopy.


Input: DESIGN: A retrospective chart review of 9, 322 patients undergoing surgical procedures in the period January 1993 to December 1998.


Input: Pulmonary vein varix in association with bilateral pulmonary vein stenosis.


Input: Biochemical experiments have shown that CopG co-operatively associates to its target DNA at low protein: DNA ratios, completely protecting four helical turns on the same face of the double helix in both directions from the inverted repeat that constitutes the CopG primary target.

CopG

CopG


Input: We demonstrated that, under serum-starved conditions, KMS-11 and OPM-2 cells express appreciable levels of phosphorylated FGFR3 mutants indicating a constitutive activation of the Y373C and K650E receptors; the addition of the aFGF ligand further increased the level of receptor phosphorylation.

FGFR3 mutants

Y373C and K650E receptors

aFGF ligand


Input: [figure: see text] The Stille coupling reaction has been performed in 1-butyl-3-methylimidazolium tetrafluoroborate (BMIM BF4), a room-temperature ionic liquid (RTIL).


Input: Special issues devoted to the biosynthesis of woody plant biopolymers and related substances.


Input: Interactions between the checkpoint abrogator UCN-01 and several pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase (MEK)/MAPK pathway have been examined in a variety of human leukemia cell lines.

mitogen-activated protein kinase (MAPK) kinase

MEK

MAPK


Input: Low affinity binding of Rab6A-GTP was also observed (K (d) = 16 microm), whereas Rab1B,-5,-7,-8, or-11A did not bind.

Rab1B,-5,-7,-8, or-11A


Input: The students who had abnormal urine screening results at the first time received a second urine analysis 10 to 15 days later to confirm the abnormal urine analysis.


Input: Regulation of laminin beta2 chain gene expression in human cancer cell lines.

laminin beta2 chain gene


Input: Northern and Western blot analyses demonstrated that Graf2 is expressed in several tissues, with the highest expression in skeletal muscle.


Input: However, when directed to the nucleosome by fusion to core histone H2A or H2B, the non-histone tail forms an MCB that appears identical to that of the endogenous protein.

core histone H2A

histone


Input: These data suggest that proper direct binding of Nhp2p to H/ACA snoRNAs is required for the assembly of H/ACA snoRNPs and hence for the stability of some of their components.

H/ACA snoRNAs

H/ACA snoRNPs


Input: Telomerase is a ribonucleoprotein complex that synthesizes telomeric DNA onto chromosomes using its RNA component as template.

Telomerase


Input: SIT (SHP2-interacting transmembrane adaptor protein) is a recently identified transmembrane adaptor protein, which is expressed in lymphocytes.

SIT

SHP2-interacting transmembrane adaptor protein


Input: Ileal digestibilities of DM, OM, CP, total dietary fiber (TDF), fat and gross energy (GE) were lower (P < 0. 05) for dogs fed diets containing supplemental fiber compared with dogs fed the control diet.


Input: Together these data imply that the HFV R region acts in the nucleus to modify the cytoplasmic fate of target HFV mRNA.

HFV R region


Input: These TxRE contain cyclic AMP-responsive elements (CRE), but, remarkably, the " TGACGTCA " consensus is never strictly conserved in any viral strain (e. g., AGACGTCA, TGACGGCA, TGACCTCA).

TxRE


Input: And, most importantly, reconstitution of a consensus CRE, within the 21-bp enhancers increases binding of CREB/ATF proteins but abrogates basal repression of LTR-directed transcription in vitro.

CREB

ATF


Input: Site-directed mutagenesis of CAR revealed that CAR residues Leu73 and Lys121 and/or Lys123 are critical contact residues, with Tyr80 and Tyr83 being peripherally involved in the binding interaction with the Ad5, Ad9, Ad12, and Ad41L fiber knobs.

CAR

CAR

Ad5, Ad9, Ad12, and Ad41L fiber knobs


Input: This subfamily of genes all have a single ATP-binding domain at the N-terminus and a single C-terminal set of transmembrane segments.


Input: The promoter activity of the proximal region was found to be restricted to a subset of prestalk cells.


Input: Substitution of serine residues at the C-terminus indicated that loss of phosphorylation sites did not appear to have any effect on transcription and replication.


Input: Thus, replication fork movement near HML pauses at a silent origin which is competent for replication initiation but kept silent through Orc2p, a component of the replication initiator.

HML


Input: These findings suggest that the adapter Gab1 may redirect c-Met signaling through PI3K away from a c-Akt/Pak1 cell survival pathway.

c-Met

c-Akt


Input: We have cloned a novel mouse protein, TAF (II) 140, containing an HFD and a plant homeodomain (PHD) finger, which we demonstrated by immunoprecipitation to be a mammalian TFIID component.

TAF (II) 140

HFD

plant homeodomain

PHD

mammalian TFIID component


Input: The other inhibitor was a single TAR decoy, driven by the U6 small nuclear RNA promoter (U6-P).

TAR

U6 small nuclear RNA promoter


Input: In contrast to MPc3, data indicate that the Pc protein M33 does not interact with AF9.

Pc protein M33


Input: Long-term results with MACOP-B and radiation therapy for aggressive lymphomas] BACKGROUND: Long-term results are needed to evaluate chemotherapy regimens and prognostic factors in non-Hodgkin' s lymphomas (NHL).


Input: At 20 days (D) and at 3 months post-TBI, irradiated rats had a significantly lower percentage of avoidance than controls but no statistical difference was found at 5 months post-TBI. b/Two-way avoidance test: this test was performed only after TBI.


Input: At the end of each day of migration the pulmonary hemolymph PO2 decreased by 1-2. 5 kPa, but the hemocyanin remained saturated with O2 and the venous reserve was largely unchanged (O2 > 0. 4 mmol x l (-1)).


Input: DESIGN: Prospective cohort study with a 20 y follow-up period, the First National Health and Examination Survey (NHANES 1) Epidemiologic Follow-up Study (NHEFS).


Input: Mean Hg concentrations in the livers of mice at some sites in Isle Royale are not significantly lower (P = 0. 62) than Hg concentrations considered by some government agencies to be unhealthy for human consumption.


Input: There are many different proposals for the statistical analysis of data to determine early onset of action.


Input: The assay herein described allows the comparison of relative FGFR expression levels, both within a single RNA pool and among multiple RNA pool samples.

FGFR


Input: The amount of drained effusion was measured, and fluid was sent for diagnostic assessment.


Input: The system, designed to exploit the relatively constant small intestine transit time, consists of a drug-containing core coated with a polymeric matrix formed by a channeling agent (NaCl, mannitol, and Emdex) and an inert polymer (Eudragit RS100).


Input: STUDY OBJECTIVE: This study assessed several methodological aspects related to the quality of published controlled clinical trials (CCTs) in relation to the participation of an epidemiologist/biostatistician (E/B).


Input: The median preoperative best-corrected visual acuity of 0. 08 (range hand motions/0. 003 to 0. 4), improved by 5 lines to a median final postoperative best-corrected visual acuity of 0. 25 (range 0. 025-0. 5) (P = 0. 001).


Input: A rare case of primary group A streptococcal peritonitis.


Input: Gimpl, F.


Input: BACKGROUND/AIMS: Hepatitis C and nonalcoholic fatty liver disease (NAFL) are the two most common forms of liver disease in the United States.


Input: Statistical Analysis included ANOVA, the Pearson Product Moment Correlation Coefficient, Principal Components Analysis and Discriminant Function Analysis and the calculation of Cronbach' s alpha (alpha) RESULTS: Both Sensitivity and specificity exceed 90. 00 at 23/24, Chronbach' s alpha for the total scale was equal to 0. 95.


Input: The titer of TSH binding inhibitor immunoglobulin (TBII), which had been 8. 6% at initial presentation, rose to 14. 9% in 2 weeks.

TSH binding inhibitor immunoglobulin

TBII


Input: Here we show that independent of uncertainties in the models, terrestrial planets with dense atmosphere like Venus can evolve into one of only four possible rotation states.


Input: Enantiomer separation of venlafaxine and O-desmethylvenlafaxine in human plasma.


Input: TE-671 cells that were transfected with cAMP response element mutant constructs demonstrated a diminished basal activity of the GnRH-II promoter.

GnRH-II promoter


Input: They consist of at least two separable components, one heat stable and the other heat labile.


Input: Altogether, we confirm that all genes of the Rad52 recombinational repair pathway are required for the survival of rad27 Delta strains at both permissive (23 degrees C) and semipermissive (30 degrees C) temperatures for growth.

rad27 Delta


Input: In the last case, both hydroxychloroquine, carbamazepine and fluvoxamine had a common imputability which was plausible.


Input: We investigate the reaction kinetics of small spherical particles with inertia, obeying coalescence type of reaction, B + B--> B, and being advected by hydrodynamical flows with time-periodic forcing.


Input: The role of the Vp1 DBD during infection was investigated by taking advantage of NLS phenotypic complementation (N.

Vp1 DBD


Input: 2 were nonviable, and the mutant Vp1s unexpectedly failed to localize to the nucleus though Vp2 and Vp3 did, suggesting that the mutated NLS1 acted as a dominant signal for the cytoplasmic localization of Vp1.

mutant Vp1s

mutated NLS1


Input: Fasting gastrin levels (normal range: 25-110 mU/L) varied from 48. 78 mU/L-168. 20 (mean: 85. 23 mU/L).

gastrin


Input: Here, we show that the phorbol ester PMA decreases both basal and dexamethasone/cAMP-induced expression of a luciferase gene under the control of the G6Pase promoter in transiently transfected H4IIE hepatoma cells.

luciferase gene

G6Pase promoter


Input: Through deletion mutagenesis, we identify amino acids 2003 to 2212 of CBP, which we call carboxy-terminal region 2 (CR2), as the minimal region for Tax interaction.

CBP

Tax


Input: Such knowledge could advance diagnosis and treatment of the patient and counseling of the affected family.


Input: BACKGROUND: There is increasing interest on the part of investigators and the public at large in finding ways to study and improve treatments for the seriously mentally ill without exposing such individuals to unnecessary risks.


Input: In the next week, the beta-adrenergic antagonist atenolol was added at an initial dose of 25 mg/day and titrated to 50 mg/day within 1 week.


Input: Lack of association between Kawasaki syndrome and infection with Rickettsia conorii, Rickettsia typhi, Coxiella burnetii or Ehrlichia phagocytophila group.


Input: The presence of AS-oligo had no further effect on the FSH-mediated activation of the EB *-mTf-CAT construct but reduced cAMP-mediated activation.

FSH

mTf

CAT


Input: This is a challenging task insofar as direct measures of ISF glucose are not readily available.


Input: We report the results of a detailed policy analysis comparing 2 CJD-related decisions: a 1995 recall of blood from a donor with classic CJD and the 1999 decision to defer donations from individuals with a 6-month travel history to the UK between 1980 and 1996 due to concerns related to variant CJD.


Input: At visit 5, the isokinetic test showed impaired muscle function recovery from 23% to 32%, while the manual test showed almost full recovery.


Input: We developed a system for domain shuffling to establish the function of C1 domains from human Raf kinase and rat PKC eta in yeast.

human Raf kinase

rat PKC eta


Input: We interpret these data as further evidence that interaction with a small GTPase is the main regulatory function of the C1 domain in yeast.

small GTPase


Input: Breast cancer risk assessment: Who holds the magic crystal ball?


Input: Patients with type III SOD may have visceral hyperalgesia; a trial of antidepressants or a therapeutic trial with botulinum toxin injection into the ampulla should be considered prior to more invasive endoscopic therapy.

botulinum toxin


Input: RESULTS: There is a considerable amount of variation between the results of TRA1 and TRA2 and between the results of both TRA' s and the door-to-door survey.


Input: In addition, these patients show both quantitative and qualitative differences in their infectious microbiological spectrum, mainly in clean-contaminated, contaminated and dirty surgical procedures.


Input: CONCLUSION: Extrusion cooking is effective for the inactivation of DON but is of limited value for AFB1, even if metabisulphite is added.


Input: The differences in the CPIgG, CRP, and fibrinogen levels in patients who were diagnosed with ACS versus those who were not (non-ACS) were evaluated.

CPIgG

CRP

fibrinogen


Input: NaeI, a novel DNA endonuclease, shows topoisomerase and recombinase activities when a Lys residue is substituted for Leu 43.

NaeI

DNA endonuclease

topoisomerase

recombinase


Input: The decrements in cerebrovascular resistance induced by hexamethonium, in mm Hg ml (-1). min (-1), were: under control.


Input: The desirability function is based on the search for a global optimum [D = f (Y1, Y2,..., Yn)] by the transformation of the measured property to a dimensionless scale for each criterion.


Input: RESULTS: In vivo, there was a wide distribution with the coefficient of variation (SD/mean x 100%) for different valve sizes ranging from 21% to 39% in the St Jude Medical valve and from 25% to 33% in the Omnicarbon valve.


Input: Even if the electrocardiographic signs are subdued, the underlying blockade of I (Kr) current may precipitate the occurrence of arrhythmia.


Input: The production of ceramide is emerging as a fixture of programmed cell death.


Input: We randomly assigned 1, 219 subjects to receive either the standard three-times-weekly (TIW) interferon alfa-2b dose (3 MIU) or the once-weekly (QW) peginterferon alfa-2b (0. 5, 1. 0, or 1. 5 microg/kg).

interferon alfa-2b

peginterferon alfa-2b


Input: At cross purposes.


Input: Among the transcription factors known to interact with Groucho-related protein, only RUNX1 was appreciably downregulated by E2A-HLF.

Groucho-related protein

HLF


Input: The combination of ifosfamide, epirubicin and etoposide (IEV) is an effective salvage regimen for lymphoproliferative disease.


Input: A prospective trial was undertaken to determine (1) clinical characteristics of patients with chest pain; (2) value of cardiac markers troponin T, myoglobin and CK-MB mass in differentiating cardiac and noncardiac chest pain; (3) the proportion of patients with ACS in whom these markers provided helpful additional information on admission and afterwards.

troponin T

myoglobin

CK

MB


Input: Cardiac markers troponin T, CK-MB mass and myoglobin were helpful in the differential diagnosis of chest pain, even when the ECG was unremarkable or nonspecific.

troponin T

CK

MB

myoglobin


Input: At termination (gd 20), confirmed-pregnant females (21 to 25 per group) were evaluated for clinical status and gestational outcome; live fetuses were examined for external, visceral, and skeletal malformations.


Input: One maternal death, reduced body weight, and reduced weight gain were noted at the high dose; confirmed pregnancy rates were 84 to 100% for each group.


Input: In the further development of bladder neck suspension according to Stamey-Pereyra, the use of miniature bone anchors received considerable support.


Input: Simulating the impact during human jumping by means of a 4-degrees-of-freedom model with time-dependent properties.


Input: A 1-base pair mismatch within the corresponding region of the CYP3A4 gene was sufficient for a differential enhancer activity.

CYP3A4 gene


Input: The authors made an analysis of social-economical conditions limiting the possibilities of rendering cardiosurgical care to children.


Input: METHODS: 93 female and 43 male patients undergoing thyroid surgery were stratified according to gender and then randomised to receive double-blind one of four antiemetic regimes: 50 mg dolasetron given orally 45 minutes prior to induction of anaesthesia (group I), 12. 5 mg dolasetron given intravenously during induction of anaesthesia (group II), 1. 25 mg DHB given intravenously during induction of anaesthesia (group III) or placebo (group IV).

DHB


Input: This slow progression through the early G1-phase resulted in decreased phosphorylation of the RB protein and subsequent delay into the S phase transition.

RB protein


Input: In mammals, the transcriptional repressors in the Wnt pathway are not well defined.

Wnt


Input: Despite abundant expression of NtmybAS transcripts in mature pollen, gPAL1 transcripts were not detectable in pollen.

NtmybAS transcripts

gPAL1 transcripts


Input: Identical effects were obtained when inhibitors and dominant negative mutants were tested on the-29 to + 139 bp region of the cyclin D1 promoter.

cyclin D1 promoter


Input: These findings suggest a novel ankyrin-independent role for LAD-1 related to FGFR signaling.

ankyrin

FGFR


Input: Moreover, elderly men with bioavailable estradiol levels below the median [40 pmol/liter (11 pg/ml)] had significantly higher rates of bone loss and levels of bone resorption markers than men with bioavailable estradiol levels above 40 pmol/liter.


Input: Competition electrophoretic mobility shift and immunoshift assays confirmed that NF1 factors present in nuclear extracts of HeLa and CV-1 cells bind to the BKV-MLP.

NF1 factors

BKV-MLP


Input: This study demonstrates that inducible expression in response to either PMA or TPO is mediated through the Ets site in the proximal promoter of GPIX and is dependent upon the upstream activation of MAPK/extracellular signal-regulated kinase.

TPO

Ets site

GPIX

MAPK

extracellular signal-regulated kinase


Input: RESULTS: The analyzed fragment has significant activity in EpCAM positive cells, and it is regulated negatively by tumor necrosis factor alpha (TNFalpha).

EpCAM

tumor necrosis factor alpha

TNFalpha


Input: On Cox proportional hazards regression adenocarcinoma (P = 0. 006), the development of BPF (P = 0. 003), older age (P = 0. 03) and higher pathological stage (P = 0. 02) were independent adverse predictors of survival.


Input: Phosphatidylinositol 3-kinase potentiates, but does not trigger, T cell proliferation mediated by the IL-2 receptor.

Phosphatidylinositol 3-kinase

IL-2 receptor


Input: In the stable transfectants (BM3 cells) expressing a mutant bacterial P450 AA epoxygenase, F87V BM3, which was genetically engineered to metabolize arachidonic acid only to 14, 15-EET, AA did not induce apoptosis and protected against agonist-induced apoptosis.

mutant bacterial P450 AA epoxygenase


Input: The loop domain of heat shock transcription factor 1 dictates DNA-binding specificity and responses to heat stress.

heat shock transcription factor 1


Input: Progressive study and robustness test of QSAR model based on quantum chemical parameters for predicting BCF of selected polychlorinated organic compounds (PCOCs).


Input: Of the six cases of malignant polyposis, none were identified using CT, and only two were diagnosed by small bowel follow-through.


Input: Using the two-hybrid system, we show that nonprenylated Rac1 interacts very weakly with Rho-GDI, pointing to the predominant role of protein-isoprene interaction in complex formation.

Rho-GDI


Input: The patterns of early mRNA and protein expression in these seven mutants were examined, and it was found that mutation of the T' (135) acceptor site resulted in the utilization of cryptic splice sites and the generation of new T' species.

T' (135)

T'


Input: Sixty-one cases of cholera, all caused by V. cholerae O1, were reported.


Input: Subsequently, these coordinates must be interpreted to define particular tissues and organs.


Input: Testing was associated with a history of nonsexual risk behavior, increased knowledge of the hepatitis C virus, and healthcare provider communication.


Input: Low-selenium diet has a human unfavourable impact.


Input: Thus, BALB/c mice appear to be the most appropriate strain of mice to perform studies on the possible connection between infection with T. canis and allergic asthma.


Input: Furthermore, hormonal regulation of G (1) gene transcription can occur even without additional activation of the Mek-Erk1/2 pathway by estrogen receptors.

Mek

estrogen receptors


Input: Therefore, to understand how ErbB1/ErbB2 signaling contributes to this process, we used the ErbB kinase inhibitor AG1478in ErbB2-dependent BT-474 and SKBR-3 human breast cancer cells.

ErbB kinase


Input: This plus the reduced phosphorylation of p27 by MAPK enhanced the stability of p27 that associated with nuclear Cdk2 at high stoichiometry and inhibited its kinase activity.

MAPK

nuclear Cdk2


Input: ICA in the reference solution was characterised by LC and time-of-flight (TOF) MS and quantified by LC chemiluminescent nitrogen detection (LC-CLND).


Input: Forced expression of BZAP45 strongly stimulates H4 promoter (nt-215 to-1)/CAT reporter gene activity.

H4 promoter

CAT


Input: Local control rates were 91% for metastatic lung cancer, 89% for primary lung cancer and 85% for T1, 2N0M0 cases.


Input: Utility of OAE screener (GSI 70) for the evaluation of distortion product otoacoustic emissions] The purpose of this study was to investigate the ability of the OAE screener GSI 70 to evaluate of cochlea function in neonates, infants and adults.


Input: For the sample of systematic reviews drawn from ACP Journal Club (n = 103), the PubMed strategy achieved a sensitivity of 97% (CI, 91% to 99%).


Input: Inhibition of JNK1 and ERK kinase activities either by expression of the dominant negative mutant JNK1 or by treatment with a selective chemical inhibitor of ERK (PD098059) substantially abrogates the UV induction of the GADD45 promoter.

ERK

ERK

GADD45 promoter


Input: With a GC content of 45% the one segment would correspond to " isochore H1 " and the other segment (39% GC in human, 40% GC in mouse) to " isochore L1/L2 ".

" isochore H1 "


Input: No mutation of the NRL gene was found in any of the two families.

NRL gene


Input: After nerve injury, the nociceptive responses through type I neurons, which are polymodal C-fibers and drive NK1-receptor mechanisms in spinal pain transmission, were completely lost, but without changes in type II ones, which are polymodal C-fibers and drive NMDA receptor-mechanisms, while type III ones, which are capsaicin-insensitive (possibly A-fibers) and drive NMDA-receptor mechanisms, were markedly enhanced.

NMDA receptor

NMDA-receptor


Input: This article reports the design and development of an ECG simulator intended for use in the testing, calibration and maintenance of electrocardiographic equipment.


Input: Subacute diencephalic angioencephalopathy (SDAE) is a rare and fatal disease of unknown etiology that involves the thalami bilaterally.


Input: Third, consistent with these data, N-acetylcysteine reduced the stimulatory effect of HGF on stress kinase activities, while p42/44 mitogen activated kinase (MAPK) was unmodified, suggesting an involvement of c-Jun-N-terminal kinase (JNK) and p38 MAPK in HIF-1 activation.

HGF

stress kinase

c-Jun-N-terminal kinase

JNK


Input: There was no significant difference in developmental scores at 9 or 18 months, although PDF infants had a 2. 8 (-1. 3-6. 8) point advantage in Bayley motor score scales.


Input: In the single case the restoration of a structured daily routine represents the presupposition for a cognitive therapy.


Input: However these search engines respond with such cumbersome results that domain specific experts can not tolerate.


Input: The binary and tertiary combinations of plant-derived molluscicides Azadirachta indica and Cedrus deodara oil with synergists MGK-264, piperonyl butoxide (PB) and fruit powder of Embelia ribes were used against the Lymnaea acuminata.


Input: From the above results, we might infer that the seizure type of TLE and a high frequency of seizure are two major independent precipitate factors for abnormal latencies of P300 in the epileptic patients.


Input: Audiological findings in pregnancy.


Input: The deubiquitinating enzyme DUB-2 is induced in response to IL-2 but as yet its function has not been determined.


Input: The isoform, designated HDAC9a, is 132 aa shorter at the C terminus than HDAC9.


Input: Pulmonary embolectomy and lung transplantation are the main indications for the use of heart-lung-machine.


Input: The NAUSICAA system gives a good knowledge of LET spectra for the first time in space dosimetry.


Input: In order to quantify these effects, tests were conducted in the NASA MSFC Neutral Buoyancy Simulator, in the NASA KC-135 in parabolic flight, and in space with the EASE program during the Shuttle Atlantis mission 61-B.


Input: This article comparatively evaluates five Generic Systems that describe the basic alternatives to composting facility design and control.


Input: Different thermoluminescent detectors (TLD) have been used to measure the contribution of the low linear energy transfer component (LET < 10 keV/micrometer) and plastic nuclear track detectors (PNTD) for the high linear energy tranfer (LET) component.


Input: Responses of TLD Mg2SiO4: Tb and radiophotoluminescent glass to heavy charged particles and space radiation.


Input: The absorbed dose was measured by combination of two integrating detectors: thermo-luminescent dosemeter of Mg2SiO4: Tb (TDMS) and plastic nuclear track detector (PNTD).


Input: Thus, while the folds of all Myb domains resemble each other closely, the function of each Myb domain depends on the amino acid residues that are located on the surface of each protein.

Myb domains

Myb domain


Input: METHODS: Experiments testing the new catheter and comparing it to the existing catheter included: (1) measurement of the laser output beam sizes and divergences; (2) evaluation of particulate matter generation during ablation of atherosclerotic tissue; (3) measurement of ablation hole sizes and tissue penetration rates; (4) histopathologic examination of laser-induced in vivo vessel wall injury.


Input: Overexpression of RORgamma has been shown to inhibit T cell receptor-mediated apoptosis in T cell hybridomas and to repress the induction of Fas-ligand and interleukin 2.

RORgamma

T cell receptor

Fas-ligand

interleukin 2


Input: Once ICP reaches critical values (> 30 mm Hg) herniation occurs, usually within 2 to 5 days.


Input: Other therapies are also available, including hypertonic saline solution, THAM (Tris-hydroxy-methyl-aminomethane) buffer, and high-dose barbiturates.


Input: CYP2C19 genotype was determined by the polymerase chain reaction-restriction fragment length polymorphism method.

CYP2C19 genotype


Input: The results indicate that a more differentiated diagnosis of the molar relationship will allow for a more causally directed correction of Class II molar relationship.


Input: Similar data were also obtained when either dominant negative EGFR-CD533 or dominant negative Ras N17 were used to block MAPK activation.

EGFR

dominant negative Ras N17

MAPK


Input: These analyses re-open the question whether all the CesA genes encode cellulose synthases or whether some of the sub-class members may encode other non-cellulosic (1--> 4) beta-glycan synthases in plants.

CesA genes

cellulose synthases

non-cellulosic (1--> 4) beta-glycan synthases


Input: The mutation experiments showed that the most critical sequence for the repression of PTH was 5'-GGGGGAGGGGAG-3' (+ 1 to + 12) of PTHSR.

PTH

PTHSR


Input: Cardiac output at anaerobic threshold (COAT) < or = 7. 3 L/min was the best cutoff value for identifying multivessel coronary artery disease (relative risk, 3. 1).


Input: Experience with xylene-free sections since 1995 at the Vrinnevi Hospital is favorable.


Input: A randomized mix of 180 sections (10 samples x 3 tissues x 3 stains x 2) gave 90 matched pairs.


Input: Interestingly, the CYP71D20-encoded enzyme activity was capable of converting both 5-epi-aristolochene and 1-deoxycapsidiol to capsidiol in vitro, consistent with the notion that this P450 enzyme catalyzes both hydroxylations of its hydrocarbon substrate.

CYP71D20-encoded enzyme

P450 enzyme


Input: In conclusion, NF-Y and Sp1 binding sites play a decisive role in the basal expression of the rat mrp2 gene, while the human MRP2 gene is regulated differently.

NF-Y

rat mrp2 gene

human MRP2 gene


Input: Transcriptional regulation of the estrogen-inducible pS2 breast cancer marker gene by the ERR family of orphan nuclear receptors.

pS2 breast cancer marker gene

ERR family

orphan nuclear receptors


Input: NB-506 completely inhibits the capacity of topoisomerase I to phosphorylate, in vitro, the human splicing factor 2/alternative splicing factor (SF2/ASF).

topoisomerase I

human splicing factor 2

alternative splicing factor

ASF


Input: However, during our work with a replication-deficient virus expressing the ASF/SF2 splicing factor from a progesterone antagonist-inducible gene cassette, we discovered that ASF/SF2 was expressed at a significant level in the 293 producer cell line, even in the absence of inducer.

ASF

ASF


Input: DNA binding assays confirmed the interference of p30 (II) with the assembly of CREB-Tax-p300/CBP multiprotein complexes on 21-bp repeat oligonucleotides in vitro.

p30 (II)

CREB

Tax

CBP


Input: Using the presented categorical structure as domain model a prototype DSS for dipslide urine cultures has been developed.


Input: DNA recognition by F factor TraI36: highly sequence-specific binding of single-stranded DNA.

F factor TraI36


Input: E47 protein levels remain high until the double positive developmental stage, at which point they drop to relatively moderate levels, and are further downregulated upon transition to the single positive stage.

E47 protein


Input: The dual specificity kinases mitogen-activated protein kinase (MAPK) kinase (MKK) 7 and MKK4 are the only molecules known to directly activate the stress kinases stress-activated protein kinases (SAPKs)/c-Jun N-terminal kinases (JNKs) in response to environmental or mitogenic stimuli.

mitogen-activated protein kinase (MAPK) kinase (MKK) 7

stress-activated protein kinases

SAPKs

c-Jun N-terminal kinases

JNKs


Input: SAPK/JNK activation was completely abolished in the absence of MKK7, even though expression of MKK4 was strongly upregulated in mkk7 (-/-) mast cell lines, and phosphorylation of MKK4 occurred normally in response to multiple stress stimuli.

SAPK

JNK

mkk7 (-/-)


Input: Thus, MKK7 is an essential and specific regulator of stress-induced SAPK/JNK activation in mast cells and MKK7 negatively regulates growth factor and antigen receptor-driven proliferation in hematopoietic cells.

SAPK

JNK


Input: When mixed with aqueous solutions of TMT-55, aqueous solutions of either reagent-grade zinc, cadmium, or lead salts precipitate crystalline " Zn-TMT ", amorphous or crystalline " Cd-TMT " or amorphous " Pb-TMT " (M3 [S3C3N3] 2. nH2O, where M = Cd2 +, Pb2 +, and Zn2 + and n > or = 0) that may eventually crystallize if stored in air.


Input: Many of the important genes associated with G1 regulation have been shown to play a key role in proliferation, differentiation and oncogenic transformation and programmed cell death (apoptosis).


Input: These results indicate the presence of TATA-unified transcription systems in contemporary eukaryotes and provide insight into the residual need for TBP by all three Pols in other eukaryotes despite a lack of TATA elements in their promoters.

TBP

Pols


Input: Thus, through a change in conformation upon repair of the 6RG lesion, MGMT switches from a DNA repair factor to a transcription regulator (R-MGMT), enabling the cell to sense as well as respond to mutagens.

MGMT

R-MGMT


Input: A split motor domain in a cytoplasmic dynein.

cytoplasmic dynein


Input: In hypertensive nephrosclerosis, therapy containing an ACEI alone or in combination significantly reduces the incidence of renal events.


Input: Body weight reduction increases insulin sensitivity and improves both blood glucose and blood pressure control.

insulin


Input: Here we suggest that uvrA and the nucleotide excision repair pathway are involved in the repair of acid-induced DNA damage and are associated with successful adaptation of S. mutans to low pH.

uvrA


Input: The best regression model for predicting changes in the WCXR included time to first positive culture and antibody titer for Pa elastase.

Pa elastase


Input: Temperature measurement in microfluidic systems using a temperature-dependent fluorescent dye.


Input: APC-resistance was determined with a functional method with high sensitivity and specificity for the factor V Leiden mutation.

APC

factor V Leiden mutation


Input: Zarix expected patient enrollment in Canadian clinical sites to begin in Spring 2001 [397955], [405928].


Input: RESULTS: The subjects in the augmented feedback group significantly reduced their peak vertical ground reaction force in both post-test conditions (2-minute post-test reduction, 0. 85 +/-0. 62; 1-week post-test reduction, 0. 74 +/-0. 58) as compared to the sensory, control I, and control II feedback groups.


Input: Four casein kinase I isoforms are differentially partitioned between nucleus and cytoplasm.

casein kinase I isoforms


Input: Use of a dual-pulse lithotripter to generate a localized and intensified cavitation field.


Input: When the blood clot is formed in the vitreous cavity, intravitreal injection of t-PA can convert plasminogen to plasmin and remove the clot.

t-PA

plasminogen

plasmin


Input: Management of postvitrectomy diabetic vitreous hemorrhage with tissue plasminogen activator (t-PA) and volume homeostatic fluid-fluid exchanger.

tissue plasminogen activator

t-PA


Input: Effect of heat treatments on the meltability of cheeses.


Input: RESULTS: Sixty per cent of African Americans exposed in 26 community outbreaks were TST positive compared to only 40% of whites following comparable exposures.


Input: The mean waiting time to receive the pancreas transplant was 244 days for SPK and 167 days for PAK recipients (P = 0. 001).


Input: Patients with antibody peaks, defined as fivefold or higher increase in antibody titer compared to the lowest antibody titer over the course of GBS, had higher disability scores during the first two weeks of GBS and a worse clinical outcome (anti-GM1 IgG and anti-GD1a IgM antibody peaks) and axonal damage (anti-GD1a IgM antibody peaks), compared to patients without peak antibody titers.

anti-GM1 IgG

anti-GD1a IgM antibody

anti-GD1a IgM antibody


Input: Following baseline clinical examination and initial periodontal therapy, 32 patients received mucogingival surgery with free gingival grafts for treatment of insufficient attached gingiva.


Input: However, patients with isolated office hypertension had fewer previous cardiovascular complications.


Input: In the TVD-patients decreases in skin blood flow were similar compared with the healthy controls.


Input: 2: The dynamic moduli of microcrystalline cellulose.


Input: These findings suggest that an intracellular WT-1/HSAL2 pathway may play a role in development and hematopoiesis.


Input: Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation.


Input: Plane wave geometry is impractical for clinical use but the results of this work encouraged us to further develop the P3 approximation for a spherical geometry, described in this paper.


Input: The diagnosis of HCV arthritis in patients with positive rheumatoid factor and chronic inflammatory polyarthritis may be difficult.

rheumatoid factor


Input: METHODS: We retrospectively selected 13 TFCD patients who underwent surgery for intractable epilepsy with the aim of removing the magnetic resonance (MR)-detectable lesion and/or the epileptogenic zone defined by stereoelectroencephalographic recordings.


Input: RESULTS: At latest examination, mean UPDRS II and III scores had improved by 30% (on stimulation, off therapy) with mean 50% reduction in daily off time.


Input: In Exp.


Input: Several distinct apoptotic stimuli induce the expression and caspase-dependent cleavage of hTAF (II) 80 delta. hTAF (II) 80 delta, unlike hTAF (II) 80, forms a TFIID-like complex lacking hTAF (II) 31.

caspase

hTAF (II) 80 delta

hTAF (II) 80 delta

hTAF (II) 80

TFIID-like complex

hTAF (II) 31


Input: Endovascular aneurysm repair with the AneuRx stent-graft is safe, but is it effective?


Input: Chronic nutritional diseases of infectious origin: an assessment of a nascent field.


Input: Drug interactions have been found with drugs that compete for the same CYP450 isoenzymes as statins.

CYP450 isoenzymes


Input: METHODS: We studied the clinical benefit of depth-dependent RR, nonuniform AC using a scanning line source, and scatter correction (photon energy recovery [PER]) compared with filtered backprojection alone.


Input: Because of differences in patient characteristics, control measurements were obtained from normal muscle in all patients.


Input: However, the abi1-1 gene product has no effect on the ABA suppression of a GA-responsive alpha-amylase gene.

abi1-1 gene product

alpha-amylase gene


Input: In children unable to perform forced expiratory maneuvers (n = 25), FOT, contrary to the interrupter technique, clearly identified a subgroup of young children with high resistance values at baseline, which returned to normal after bronchodilation.


Input: In budding yeast, this latter checkpoint response involves the proteins Mad1, 2, 3, Bub1 and Bub3, whose vertebrate counterparts localize to unattached kinetochores.

Mad1, 2, 3


Input: HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis.


Input: However, the beta5L splice variant was found only in the retina.


Input: PROCEDURE: Cannulas were surgically positioned in the abomasal body and pyloric antrum of each calf.


Input: METHODS: Humphrey Field Analyzer model 630 (HFA I, program 30-2 with a rectangular 6 degrees x 6 degrees grid) was used as the conventional perimetric method.


Input: Transforming growth factor-beta (TGF-beta) induced growth arrest of cells involves regulation of the activities of both D-and E-type cyclin kinase complexes thought to be mediated primarily by the regulation of p15 (Ink4b) and p27 (Kip1) cyclin kinase inhibitors.

Transforming growth factor-beta

TGF-beta

D-and E-type cyclin kinase complexes


Input: Alignment of different cDNAs of the NR5A2 (hB1F) gene with the genomic sequence facilitated the delineation of its structural organization, which spans over 150 kb and consists of eight exons interrupted by seven introns.


Input: The genomic structure of the human SPEC1 gene reveals complex splicing and close promoter proximity to the AF1q translocation gene.

human SPEC1 gene

AF1q translocation gene


Input: Hp positive relatives of gastric cancer had a markedly higher prevalence of atrophy than those with Hp negativity without cancer relatives (29 vs.


Input: Peripheral metabolism of androgens takes place in various areas within the pilosebaceous unit, as indicated by local differences in the activities of aromatase, 5alpha-reductase as well as of the presence of the androgen receptors.

aromatase

androgen receptors


Input: The uptake of fluorine-18 fluorodeoxyglucose (F-18 FDG) by a malignant tumor depends on the blood glucose level.


Input: This analysis supports the use of fluticasone propionate 88 microg twice daily as first-line treatment in patients with persistent asthma previously treated with short-acting beta2-agonist alone.


Input: By using space-discrete/continuous metapopulation dynamic models and computer simulations, we show that there can be two principally different regimes of metapopulation dynamics.


Input: Eight CAD patients who were matched to the treated patients for age (+/-3 years), baseline low density lipoprotein (+/-5 mg/dL), and triglycerides (+/-50 mg/dL) but who had never been treated with lipid-lowering drugs were selected as controls.

low density lipoprotein


Input: RESULTS: A novel gene was cloned.


Input: The moduli of elasticity of the gray and white matter were 3. 4 +/-1. 4 kPa (mean +/-standard deviation) and 3. 4 +/-0. 9 kPa in the axial section, 3 +/-0. 3 kPa and 3. 5 +/-0. 5 kPa in the frontal section, and 3. 5 +/-0. 9 kPa and 2. 8 +/-0. 4 kPa in the sagittal section, respectively.


Input: Direct current polarography and differential pulse polarographic methods have been developed for the qualitative as well as quantitative analysis of vitamin B1, B2 and B6.


Input: Against gram-positive organisms, E-4767 and E-5065 were, in general, eight-and fourfold more active than tosufloxacin, which is the most potent of the reference compounds.


Input: However, most produced significant alteration of small intestinal permeability.


Input: These included HNF-3 beta, HFH-1, HFH-2, HFH-3, C/EBP, and C/EBP beta, all of which are consistent with the tissue-specific expression profiles of the gene.

HNF-3 beta

C/EBP

C/EBP beta


Input: Managing vertigo and vertigo syndromes in the elderly


Input: The MABP and MCBFV signals were bandpass filtered in the very low-frequency range (VLF, 0. 015-0. 07 Hz), low-frequency range (LF, 0. 07-0. 15 Hz) and high-frequency range (HF, 0. 15-0. 40 Hz) before applying CCF for the purpose of studying the effect of different bandwidths on the resulting mean CCFs.


Input: Hepatitis B and C seroprevalence rates among high-risk adolescents are lower in El Paso than in other similar US populations, presenting an ideal climate for prevention programs.


Input: A twelfth insertion disrupts two genes, Nrk, a " neurospecific " receptor tyrosine kinase, and Tpp, which encodes a neuropeptidase.

Nrk

" neurospecific " receptor tyrosine kinase

Tpp

neuropeptidase


Input: Not Available


Input: This unique work needs to be edited critically and afterwards translated into Urdu and other languages for the benefit of the present day students and scholars.


Input: Comparison of German language versions of the QWB-SA and SF-36 evaluating outcomes for patients with prostate disease.


Input: Disciplinary action for DNA violation.


Input: Epithelial cytotoxicity of combined antibiotics was additive, with no evidence of competition or synergism.


Input: Pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-alpha), produced from adipose tissues in obese subjects, is known to play a predominant role in inducing insulin resistance.

tumor necrosis factor-alpha

TNF-alpha

insulin


Input: The most important finding, however, was that IMT values were related with 24 h SBP or PP standard deviation (P < 0. 001), a measure of overall SBP or PP variability.


Input: The difference between the patients and the controls was statistically significant (p = 0. 03).


Input: The effect of crude oil spillage on growth, productivity and nutrient uptake of maize (Zea mays L.) was assessed in a pot experiment using an Evwreni manifold sample of a petroleum development company, which had a specific gravity of 0. 8778.


Input: NO metabolites were determined by the measurement of nitrate/nitrite (NOx, micromol/mmol creatinine) and cyclic guanosine monophosphate (cGMP, nmol/mmol creatinine) in plasma and urine.


Input: In the base-case analysis, total direct costs per patient were $728 for zoledronic acid and $776 for pamidronate.


Input: The diet of migrants showed both positive (macronutrients) and negative (micronutrients) differences with the general Dutch diet.


Input: C. elegans embryogenesis begins with a stereotyped sequence of asymmetric cell divisions that are largely responsible for establishing the nematode body plan.


Input: Finally, a chromogenic method was used, based on thrombin inhibition and the substrate S-2238.

thrombin


Input: [Diabetologia (2001) 44 [Suppl 3]: B37-B44]


Input: The 5' flanking sequence of the 3B gene is extremely A + T rich but contains five G/C rich stretches, each approximately 7bp long, which have strong sequence similarity to the G boxes found upstream of other developmentally regulated Dictyostelium genes.

3B gene


Input: Considering that the reactor is thoroughly mixed during each discharge and that LD50 = 0. 9 values are nearly independent of E. coli concentrations in the range of 2 x 10 (3) < or = E coli/cfu mL (-1) < or = 3 x 10 (6), we ascribe the nonexponential Pn decay of single-strain E. coli colonies to a shielding phenomenon where inactive cells protect the successively smaller numbers of viable cells in the EHD.


Input: In the long term, questions still remain about whether pre-dialysis rHu EPO either speeds up or delays the onset of dialysis.

rHu EPO


Input: METHODS: This retrospective review comprised 2711 eyes that had LASIK between September 1996 and September 1999.


Input: No ISREs could be identified in the mouse promoter.

ISREs


Input: BACKGROUND: Ischemic heart disease is the primary cause of morbidity and mortality among diabetics, especially those who became ill at a young age.


Input: A 38-year-old woman with ulcerative colitis subsequently developed sarcoidosis.


Input: Cholesteryl ester transfer protein and atherosclerosis in Japanese subjects: a study based on coronary angiography.

Cholesteryl ester transfer protein


Input: Electrophoretic mobility shift assays and coimmunoprecipitation studies suggest that homo-and heterodimerization occurs between cKrox family members.

cKrox family members


Input: The hcKrox gene family regulates multiple extracellular matrix genes.

hcKrox


Input: A review of the literature identified 8 comprehensive clinical studies, all of which failed to document any relationship between NF1 and intracranial aneurysms.


Input: These utilisation data imply annual drug costs in the range of $US 480, 000 to $US 3, 600, 000 for TNF antagonists for RA per 1 million population.

TNF


Input: This study investigated whether boron would enhance the ability of 17beta-estradiol (E2) or parathyroid hormone (PTH) to improve bone quality in ovariectomized OVX rats.

parathyroid hormone

PTH


Input: We found in the control subjects rCBF increases in regions associated with the meso-striatal and meso-corticolimbic circuits in response to both monetary reward and nonmonetary reinforcement.


Input: Doxorubicin (DOX) is commonly used for the treatment of hematological and solid tumors.


Input: The event rate in patients with chronic Irr-rMFP or Un-nrMFP was markedly higher than it was in those with Rev-rMFP or Sta-nrMFP.


Input: Subtraction hybridization identified melanoma differentiation associated gene-7 (mda-7), as a gene induced during these physiological changes in human melanoma cells.

melanoma differentiation associated gene-7


Input: Therefore, vitamin D3 analogues have a substantial antipsoriatic effect.


Input: Hydrocoele is common in men in Wuchereria bancrofti-endemic areas, the treatment for which is currently surgical intervention.


Input: Growth hormone and insulin-like growth factor I receptors in the temporomandibular joint of the rat.

Growth hormone

insulin-like growth factor I receptors


Input: In addition to that, she received hepatic intra-arterial infusion of levoforinate (l-LV) 250 mg and 5-fluorouracil (5-FU) 500 mg for combined multiple hepatic metastases starting on postoperative day 14, and these medications were administered over 48 hours once weekly by infuser pump.


Input: The astronaut crew operates the payload and documents its operation.


Input: For these patients the introduction of a separate category " extended oligoarthritis at onset " should be considered to establish comparable patient groups.


Input: Phase II trial of the anti-G (D2) monoclonal antibody 3F8 and granulocyte-macrophage colony-stimulating factor for neuroblastoma.

anti-G (D2) monoclonal antibody 3F8

granulocyte-macrophage colony-stimulating factor


Input: Hepatitis A infected food handler at an Edmonton, Alberta retail food facility: public health protection strategies.


Input: Hydrogels for tissue engineering.


Input: Eliminating any subset of ASCUS reduces the ASCUS/SIL ratio but also significantly diminishes the sensitivity of the Papanicolaou test.


Input: Eliminating any subset of ASCUS reduces the ASCUS/SIL ratio but also significantly diminishes the sensitivity of the Papanicolaou test.


Input: Two nuclear medicine physicians blinded to the surgical findings interpreted all available images and various Tc-99m MIBI image combinations at 15 minutes alone; 15 minutes and 2 hours, 15 minutes and 4 hours; and 15 minutes and 2 and 4 hours each with and without correlative pertechnetate thyroid imaging.


Input: Between 1967 and 1994, 495 patients underwent surgery for primary PTC at the Department of Surgery, Helsinki University Central Hospital.


Input: ISS and the acute physiology and chronic health evaluation (APACHE II) calculated on admission.


Input: The procedure is less aggressive and painful than sternotomy.


Input: Paul Monagle addresses the epidemiology of neonatal thrombosis outside of the central nervous system in both arterial and venous locations, and those that occur in utero.


Input: [Clinical and epidemiological characteristics of squamous cell carcinoma of the oral cavity in women] BACKGROUND: Squamous cell carcinoma (SCC) of the oral cavity occurs mainly in the male population.


Input: Regarding gestational risk, 3, 243 drugs used (34%) belonged to category A risk, 1, 923 (22. 6%) to category B, 3, 798 (39. 7%) to category C, 289 (3. 0%) to category D, and 55 (0. 6%) to category X.


Input: The process has been applied to the river reclamation in Yangpu District of Shanghai City, China.


Input: Physical principles in therapeutic apheresis.


Input: Rind et al.' s study' s main conclusions were not supported by the original data.


Input: Of major concern to food processors is the inadvertent cross-contact of food products with allergenic residues, which could result in potentially life-threatening reactions in those with a food allergy.


Input: Lactate accumulation peak was unaffected by supplementation (HMB, 8. 1 +/-1. 1 mM; LEU, 6. 2 +/-0. 8 mM; CON, 7. 5 +/-1. 3 mM).


Input: The increased clearance observed in young infants is in contrast to other opioids.


Input: These results were robust to changes in the baseline assumptions of the model.


Input: CONCLUSION: The training of novices using MIST-VR yields quantifiable changes in skill that are transferable to a simple real task and are similar to the results achieved with conventional training.


Input: The patients and their families were closely questioned, and full clinical examination included a test for orthostasia.


Input: They have not been previously reported as a reaction to i. v. contrast material.


Input: There was a statistically significant correlation between simultaneous weekly average pollen levels in Philadelphia and in Cherry Hill (Acer, r (p) = 0. 987, Quercus, r (p) = 0. 645, Betula, r (p) = 0. 896, Pinus, r (p) = 0. 732, Cupressaceae, r (p) = 0. 695, Poaceae, r (p) = 0. 950, Ambrosia, r (p) = 0. 903, and Rumex, r (p) = 0. 572, P < 0. 001).


Input: Encouraged by a Dutch study using etidronate/fluoride in corticoid-induced osteoporosis, we performed a pilot study in 33 men with severe established primary osteoporosis giving cyclically etidronate for 14 days followed by fluoride plus calcium/vitamin D for 76 days.


Input: In order to overcome the false positive readings that are possible in sphincter manometry, we proposed to use secretin stimulated endoscopic ultrasound (SSEUS) to measure pancreatic ductal response as an adjunctive method to aid and supplement the diagnosis.

secretin


Input: The cut-off percentage positivity value was established using 500 brucellosis-positive and 500 brucellosis-negative serum samples, confirmed with reference to the sample data using the indirect ELISA kit.


Input: An analysis of the dynamics is performed of exactly solvable models for fragile and strong glasses, exploiting the partitioning of the free-energy landscape in inherent structures.


Input: Fifty-six semen samples were included in this study; 18 were subnormal (G1) and 38 were normal (G2) based on World Health Organization criteria, except for morphology, which was evaluated according to strict criteria.


Input: At this timepoint, many leucocytes in the ME and ET mucosa had incorporated BrdU (between 15 and 25% within the subsets).


Input: Their chemical structures were elucidated as 1 alpha, 2 alpha-diacetoxy-8 beta-isobutanoyloxy-9 alpha-benzoyloxy-13-(alpha-methyl) butanoyloxy-4 beta, 6 beta-dihydroxy-beta-dihydroagarofuran (1), 1 alpha, 2 alpha-diacetoxy-8 beta-(beta-furancarbonyloxy)-9 alpha-benzoyloxy-13-isobutanoyloxy-4 beta, 6 beta-dihydroxy-beta-dihydroagarofuran (2) and 1 alpha, 6 beta, 8 alpha, 13-tetraacetoxy-9 alpha-benzoyloxy-2 alpha-hydroxy-beta-dihydroagarofuran (3) mainly by analyses NMR and MS spectral data.


Input: Saunders Company.


Input: Acute stress in 7 rats also increased the mean amount of IL-6 released in the urine by 31. 5% from 775. 9 +/-69. 2 to 1, 021. 1 +/-93. 3 pg./ml.


Input: Patients with CF and meconium ileus presented a poor nutritional status at diagnosis and a lower survival rate compared to the general CF population.


Input: (Cactaceae) waste matter.


Input: Skin cancers, followed by gastrointestinal tract and male genital system affected mostly older age patients.


Input: CONCLUSION: MMF (2-3 g/day) is unable to control the signs of mucocutaneous Adamantiades-Behcet' s disease.


Input: In the treatment of opioid naive patients who underwent surgery and received opioids for acute pain, oral ADL 8-2698 (6. 0 mg) improved the management of postoperative ileus (POI) by shortening the time to achieve normal bowel function and, ultimately, hospital stay.


Input: Evidence suggests that PHACES syndrome is not a random association but a true phakomatosis; further studies are awaited to shed light on a possible genetic background.


Input: Moreover, a severe decrease of antithrombin activity became evident during both experiments (eg, in experiment 2 from 95. 6 +/-4. 8 to 59. 2 +/-6. 6%).

antithrombin


Input: The Penn State Worry Questionnaire for Children (PSWQ-C) is a 14-item self-report questionnaire that intends to measure the tendency of children to engage in excessive, generalized, and uncontrollable worry (Chorpita et al., Behav.


Input: Described X-ray projection were performed in 70 patients.


Input: Pyrethroid insecticides are widely used in agriculture and private households.


Input: The sorption mechanisms changed from adsorption to partition in the process of repetitious sorption.


Input: Although the spatial and temporal variability of LDF signals evoked by cerebrocortical microflow is in the same range as with other methods and in other organs, LDF cerebrocortical mapping is restricted by the large temporal and spatial heterogeneity of the cerebrocortical vasculature.


Input: The 5-year overall survival (OS) and progression-free survival (PFS) rates were 58. 9% and 55. 4% for arm A and 44. 5% and 41. 3% for arm B (P =. 007 and P =. 02), respectively.


Input: METHODS: P-selectin expression of nonstimulated and ADP-stimulated platelets was flow cytometrically measured before the clopidogrel loading dose and on 3 consecutive days in 52 patients with coronary artery disease: 21 patients in group 1 received 300 mg of clopidogrel after stent implantation and 11 patients in group 2 received the higher 450-mg clopidogrel loading dose followed by a daily dose of 75 mg of clopidogrel for both groups.

P-selectin


Input: Traditional surgical exploration was followed by survey with a gamma-detecting probe.


Input: No effect of the intervention on depression scores was found.


Input: IV. combined sclerosis and resorption of the skull base (6 cases, 2 group I lesions and 4 group II lesions).


Input: The quantity of each population (L. bulgaricus, S. thermophilus) was then estimated in the pellet by PyMS, and the data were analysed by artificial neural networks (ANNs).


Input: AF showed a mixed nuclear/cytoplasmic pattern of expression in the epithelial, endothelial, and stromal component of the normal breast and benign lesions, whereas an impressive loss of AF expression was noted in in situ and invasive breast cancer and tumoral stroma.

AF

AF


Input: We derive joint probability density distributions for three key uncertain properties of the climate system, using an optimal fingerprinting approach to compare simulations of an intermediate complexity climate model with three distinct diagnostics of recent climate observations.


Input: Frequency of seeing curves were examined for the method most similar to FDT.


Input: Chronic graft-versus-host disease (cGVHD) is a major complication of allogeneic hematopoietic cell transplantation.


Input: Compared to white-on-white (W-W) perimetry, SWAP is limited clinically by: greater variability associated with the estimation of threshold, ocular media absorption, increased examination duration and an additional learning effect.


Input: Preservatives are an important component of ophthalmic preparations, providing antimicrobial activity in the bottle and preventing decomposition of active drug.


Input: Comparative analysis of various techniques of prostatic drainage in patients with chronic obstructive prostatitis] The efficacy of prostatic drainage using transurethral vacuum aspiration (Introl-4 unit) and transrectal pneumovibromassage (PVM-R-01) was compared in 1511 patients with chronic obstructive prostatitis.


Input: Consumption of 4% sucrose was not affected by excitotoxic lesions of the PPTg, but PPTg lesioned rats consumed significantly more 12% and 20% sucrose than sham controls.


Input: Actuarial freedom from ventricular arrhythmias at 4-year follow-up was 74. 1 +/-6. 0% in group A vs.


Input: Mental development is generally normal.


Input: Influence of different methods of chemical disinfection on the physical properties of type IV and V gypsum dies] Several instruments and materials frequently used in prosthodontics--such as stone casts, dental impressions, interocclusal records--are classified, by the dental literature, as vehicles of transmission of infectious diseases to those who handle them.


Input: Vitrectomy and removal of retained lens fragments restores good visual acuity and reduces secondary glaucoma in the majority of patients.


Input: CONCLUSIONS: The mechanism of MIRI is Qi deficiency and blood stasis in TCM, its treating principles should be promoting Qi and removing the blood stasis.


Input: Effects of activating blood circulation to remove blood stasis on barrier action of gastric wall in chronic atrophic gastritis


Input: Proteomic patterns of nipple aspirate fluids obtained by SELDI-TOF: potential for new biomarkers to aid in the diagnosis of breast cancer.


Input: According to the laboratory results, the application of neural network can solve the problem successfully.


Input: A high-efficiency cross-flow micronebulizer interface for capillary electrophoresis and inductively coupled plasma mass spectrometry.


Input: The experimental results showed that the coagulation-electrooxidation process could efficiently remove the color and the COD from the simulated dye wastewater.


Input: Cyclic loading of bone during normal daily activity leads to the formation of microcracks within the tissue matrix of compact bone.


Input: The weight-bearing surface of the PE head became smoother with time after THA, and the friction coefficient did not differ significantly from that of an unused PE head.


Input: OBJECTIVE: To demonstrate a lack of effect of steady-state concentrations of cilomilast, a new oral phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease, on warfarin-induced anticoagulation.

phosphodiesterase 4


Input: Postdocs face hardship across mainland Europe.


Input: The design principle based on a uniform vibration mode is presented.


Input: Dynamic imaging of nuclear wave functions with ultrashort UV laser pulses.


Input: Efficacy and safety of aspirin in the long-term management of atherothrombosis.


Input: The General Practice Research Database (GPRD) is the world' s largest computerized database of anonymized longitudinal patient records from general practice and is a unique public health research tool.


Input: This paper reports the results of a laboratory study on aldicarb and its main metabolites, aldicarb sulfone and aldicarb sulfoxide.


Input: Only one DC cardioversion was required in the HBS group, whereas 2 DC in the CBC group and total 7 DC in the GIK group.


Input: Since August 1994, the ENRP has retained 70. 3 metric tons of TP that otherwise would have entered the Everglades.


Input: It was found that the disappearance of BOD5 and NH3-N could be approximated using first-order kinetics, but the kinetics of TP removal were unclear.


Input: It was found that the disappearance of BOD5 and NH3-N could be approximated using first-order kinetics, but the kinetics of TP removal were unclear.


Input: Losses of dichlofluanid (54%), chlozolinate (22%), and etridiazole (40%), previously reported to occur during ambient processing of apples, were reduced to barely significant levels (10, 17, and 14%, respectively) by cryogenic processing.


Input: The TB incidence in the " AIRIN " area, where about 20% TB patients are homeless, shows highest rate of above 1, 000/100, 000.


Input: It is shown that the displacement distribution measured by q-space MRI in both the large displacement (i. e., large r) and the long-wavelength (i. e., small q) limits is the same 3D Gaussian displacement distribution assumed in DT-MRI.


Input: The procedure facilitated the retention of a mandibular molar with a Class III FI in a manner acceptable to both the patient and the clinician.


Input: The results of our ten-fold cross-validation experiments show that, on the average, the system increases the specificity from 0. 19 (0. 35) to 0. 69 (0. 74) at a sensitivity level of 1. 0 (0. 95).


Input: The physical characteristics of these calls vary among species of bat, and variations also exist in the timing and patterns of respiratory muscle recruitment during echolocation.


Input: Clicking on " Examples and Explanations of APA Form " provides a help system with examples of the various sections of a review article, journal article that has one experiment, or journal article that has two or more experiments.


Input: The drug packets contained acetyl aspirin, acetaminophen and chloramphenicol.


Input: Karger AG, Basel


Input: AIM: To understand the role of nutritional status in cirrhotic patients without clinical porto-systemic encephalopathy (PSE). METHODS: Fifty-one non-alcoholic patients with cirrhosis without PSE were studied prospectively and compared with 20 healthy volunteers.


Input: MAIN OUTCOME MEASURE (S): Serum levels of FSH, LH, and inhibin A and B.

FSH

LH

inhibin A and B


Input: For instance, a total SIP score of an individual patient of 28. 3% (which is taken as an example, being the mean score in the study population) should decrease by at least 9. 26% or approximately 13 items, before any improvement beyond reproducibility noise can be detected.


Input: Group I comprised 5 adult Collies that received at least 400 microg/kg ivermectin p. o. and were presented to the VMTH 3 hours after intoxication.


Input: No increased tumor-related mortality was observed after a mean follow-up of 44 months.


Input: Dissociable effects of lidocaine inactivation of the rostral and caudal basolateral amygdala on the maintenance and reinstatement of cocaine-seeking behavior in rats.


Input: The population studied comprised 4472 men and 5212 women aged 30-74 years, without coronary heart disease, who had CRP measurements in the Third National Health and Nutrition Examination Survey (NHANES III).

CRP


Input: Herceptin, which recognizes the HER-2/neu antigen and has similar size (10 nm) to G6-(1B4M-Gd) (256), accumulated and internalized in the WIBC-9 tumors more quickly than in the control MC-5 tumors that progress with normal angiogenesis.

neu


Input: Forty-eight pigs were removed from sows at 1 d of age and randomly assigned to one of three treatments: 1) control with lactose as the carbohydrate source, 2) lactose replaced (gram for gram) with CSS (dextrose equivalent [DE]-20), and 3) lactose replaced with DE-42.


Input: CONCLUSIONS: AMVT is rare but a potentially lethal emergency disease.


Input: Therefore, in a large animal model of permanent focal ischemia in which transfusion starts 30 min after ischemia, tetrameric cross-linked hemoglobin transfusion can augment oxygen transport to the ischemic cortex, but the increase can be delayed and not necessarily provide protection.

hemoglobin


Input: Since the early 1980s there has been increasing awareness of the importance of quantifying health-related quality of life (HRQL) in patients with chronic respiratory disorders included in clinical trials.