Input: A prospective trial was carried out in 156 unselected patients (41 men, mean age 67. 5 years, 115 women, mean age 71. 4 years) who had undergone total hip joint replacement because of degenerative or inflammatory arthritis or fracture of the neck of the femur.


Input: When both lesions were complete lateral hemisections in weanling operates, little behavioral recovery was observed, similar to complete spinal cord transection (N = 3).


Input: Human SRF-related proteins: DNA-binding properties and potential regulatory targets.

SRF-related proteins


Input: We have isolated cDNAs for a gene coding for a G protein alpha subunit from tomato (Lycopersicon esculentum, cv.

G protein alpha subunit from tomato


Input: Growth factor stimulation of cells causes the phosphorylation of the c-Myc transcriptional activation domain at Ser62 within a proline-rich region that is highly conserved among members of the Myc family (Alvarez, E., Northwood, I. C., Gonzalez, F.

c-Myc transcriptional activation domain

Myc family


Input: The authors evaluated the potential for thrombotic complications arising from implantation of a ventricular assist device (Sarns/3M-VAD) in four calves.


Input: Cardiac output (CO) was significantly higher (p less than 0. 0005) in the MBBF group.


Input: Amino acid residues 147-167 of the previously reported sequence are replaced by new residues 147 to 150.


Input: Transcriptional activation by the HIV-1 Tat protein requires specific residues in the hexanucleotide loop and trinucleotide bulge of the TAR RNA stem-loop structure found in the 5'-untranslated leader of all viral transcripts.

HIV-1 Tat protein

TAR


Input: These results strongly suggest that locally-applied TTC in combination with FDBA enhances new bone formation in experimental alveolar bone defects.


Input: As an initial step towards the characterization of replicative DNA polymerases of trypanosomes, we have cloned, sequenced and examined the expression of the Trypanosoma (Trypanozoon) brucei brucei gene that encodes the DNA polymerase alpha catalytic core (pol alpha).

DNA polymerases of trypanosomes

DNA polymerase alpha catalytic core

pol alpha


Input: In addition, there was a significant increase in postdexamethasone cortical concentrations with age (p less than 0. 01; r = 0. 31).


Input: The volume fraction (Vv) and number/mm2 (Na) of all capillaries (perfused and nonperfused) in a given area of brain were determined after staining for alkaline phosphatase.

alkaline phosphatase


Input: Airway pressure and air flow were measured at the endotracheal tube in 13 children on a variety of ventilators.


Input: Appl.


Input: Issues of distribution of kinetic energy of traumatizing object in direct contact interaction with head during impact are discussed from position of biomechanics.


Input: CONCLUSION: Monitoring SpO2 at the nasal septum site is more reliable than monitoring it at the finger site in hypothermic patients.


Input: The granules grew as the melted material immersed into the void space among the adhered particles.


Input: Hence, the uPA promoter contains multiple weak cis-acting elements distributed over 7. 0 kb 5' to the translation start site.

uPA promoter


Input: Substituting a Ser for Gly69 or a Glu for Lys 71 in the conserved TGEK tetrapeptide in finger II of TFIIIA resulted in the loss of DNA binding.

TGEK tetrapeptide

TFIIIA


Input: P.


Input: In one, exploratory behavior (assessed by hole pokes) and locomotion were assessed during a 10-min test session.


Input: 12-O-Tetradecanoylphorbol 13-acetate was found to inhibit rapidly and potently the expression of mRNAs coding for the myogenic regulators CMD1 and myogenin.

myogenin


Input: In Xenopus laevis, the gene encoding the elongation factor 1-alpha variant EF-1 alpha O, where O stands for oocyte, is expressed in oocytes and early embryos.

elongation factor 1-alpha variant EF-1 alpha O


Input: These introns belong to the class of nuclear pre-mRNA introns and contain typical 5'-and 3'-consensus sequences, as well as unique features.


Input: The mRNA identified in both human and rat cells with the human clathrin clone revealed transcripts of approximately 6. 5 kb, which is consistent with the predicted 180 kDa molecular weight of the clathrin heavy chain.

human clathrin

clathrin heavy chain


Input: In this report, almost 6 kb of DNA sequence is presented, including 1251 bp 5' to the gene, over 4 kb of exon and exon-intron junctions, and 583 bp 3' to the gene.


Input: Antibodies specific to rE12 and rNFIL-6 disrupt nucleoprotein complexes with these DNA-binding sites, confirming the interaction of native in vivo factors.


Input: A method is described for detecting targeted events at the mu heavy chain gene which relies on co-conversion (or co-exchange) of a point mutation with a selectable marker contained on a replacement vector.

mu heavy chain gene


Input: Allergenic activity of allergen extract Ambrosia elatior (AE) was tested in fifteen volunteers extremely sensitive to the allergen.


Input: This study was aimed at assessing whether c-DDP administration immediately before radiotherapy could increase frequency and duration of objective responses, as well as survival, in patients affected with locally advanced stages of squamous carcinomas of the head and neck.


Input: Two potential regulatory sequences for DNA binding proteins were found in the non-coding 5' region: a HAP2/HAP3 consensus recognition sequence at nucleotide-154 and a BAF1 consensus recognition sequence at nucleotide-136.

BAF1 consensus recognition sequence


Input: We exploit the properties of LexA fusion proteins to study the dimerization and DNA-contacting domains of cRel.

LexA fusion proteins

cRel


Input: Plasma lipid and lipoprotein profiles were compared in elderly female runners (RU: n = 15, aged 66 +/-5 years, body fat 20 +/-4%, training distance 35 +/-15 km week-1, VO2max 36 +/-4 ml kg-1 min-1, mean +/-SD) and age-matched untrained women (UT: n = 28, 66 +/-4 years, body fat 26 +/-6%, VO2max 26 +/-3 ml kg-1 min-1).


Input: Fundamental and clinical evaluation of equilibrium dialysis--radioimmunoassay system for measurement of serum free thyroxine


Input: We conclude that TA caused a specific decrease in AGD on GD 20 that was largely reversed by PCD 23.


Input: When examined as adults (8 weeks old), the external genitalia of TA-exposed offspring were normal.


Input: After PTCA, ejection fraction increased from 54 +/-8% to 59 +/-8% (p less than 0. 05) and regional function improved significantly (maximal standard deviation before PTCA: 2. 8 +/-0. 8; after PTCA: 1. 9 +/-0. 9-segments below the first standard deviation before PTCA: 31 +/-16; after PTCA: 19 +/-17).


Input: The alcoholic patient, his work and the subjectivity of the period


Input: These data suggest that the combined treatment with a thromboxane synthetase inhibitor and a thromboxane receptor antagonist provides a better protection against digoxin intoxication than with either agent alone.

thromboxane synthetase

thromboxane receptor


Input: A 330-kb YAC, A148A7, spanned from the HLA-DQA1 locus through the Y3/Ring 4 locus and extended at least 130 kb centromeric of YAC B1D12.

HLA

Ring 4


Input: Adverse foetal outcome in specific IgM positive Chlamydia trachomatis infection in pregnancy.

IgM


Input: Using an image-processing computer, regional LV time-density curves were constructed for one cardiac cycle.


Input: In a second patient the VT became nonsustained.


Input: The possible mechanisms underlying differences in post-tetanic effects from muscle and cutaneous afferents in adults and neonates are discussed.


Input: We examined behavioral alterations in the brown cockroach, Periplaneta brunnea, infected with the acanthocephalan, Moniliformis moniliformis.


Input: First, the finding of a monomeric Alu family repeat at the junction between nonhomology block I and homology block Y of the alpha 2 gene-containing unit in rhesus macaque suggests that the dimeric Alu family repeat, Alu 3, at the orthologous position in human was generated by insertion of a monomeric Alu family repeat into the 3' end of another preexisting Alu family repeat.

Alu

alpha 2 gene-containing unit in rhesus macaque

Alu

Alu 3

Alu

Alu


Input: The sequence of the repressor locus, c, of the Streptomyces temperate phage, phi C31, was shown previously to contain an open reading frame encoding a 74 kDa protein.


Input: This differential sensitivity to DB, as measured by a lower concentration of DB which caused loss of righting in LS, was accompanied by an equal rate of water-soluble barbiturate brain distribution and elimination in the two lines.


Input: The existence of threshold concentrations, above which certain phenomena may occur, strengthens the role of sentinels.


Input: However, it was synthesized at both temperatures after addition of A23187.


Input: Ten out of 10 patients with progressive disease had mast cells greater than or equal to 0. 5%, hyaluronan greater than or equal to 50 micrograms. l-1 and fibronectin greater than or equal to 350 micrograms. l-1 compared to eight out of 41 patients with stable or regressive disease. (ABSTRACT TRUNCATED AT 250 WORDS)

fibronectin


Input: Our mapping results did not suggest involvement of this gene in previously mapped genetic disorders or in known neoplasia-associated translocation breakpoints.


Input: These changes weren' t so significant in the group of obese children who didn' t lose weight.


Input: Arsenic contents in native copper


Input: In ten other experiments (5 experimental and 5 control rats) 99mTc-sulfur colloid was injected intravenously.


Input: Magnetotherapy of hepatitis A and B in children


Input: These results were superior to those in 24 patients with conventional end-to-end sutures on clinical testing.


Input: Mutational analysis supports a role for multiple structural features in the C-terminal secretion signal of Escherichia coli haemolysin.

Escherichia coli haemolysin


Input: Among blood donors in the Republic of Serbia, regardless the number of blood donations, the percentage of female donors is significantly lower compared to the percentage of male blood donors.


Input: Extramedullary relapse in childhood leukemia.


Input: Mycoplasma pneumoniae was isolated from the pleural fluid of this patient.


Input: RU486 and ONO 802 in combination have been shown to be effective in early termination of pregnancy.


Input: The presence of local abnormalities in both patients can support the hypothesis that the cortex, especially of the temporal anterior lobe, is involved in the origin of the laughing seizures.


Input: In line with the small values for QS/QC, our results further indicate that even large, well-perfused, occluded air spaces in the lung will hardly affect the recovered ventilation/perfusion distribution obtained from inert gas data when CDCSF6 exceeds 0. 1 ml. min-1. mmHg-1.


Input: Many cells were negative for endothelial-cell markers, and they reacted with a monoclonal antibody against muscle actin.

actin


Input: CT abnormalities noted in term babies included hemorrhage (subarachnoid 5. 8%, intracerebral 11. 6%), hypodensity (mild 23. 2%, moderate 11. 6% severe 5. 8%); hypodensity with hemorrhage 5. 8% and cerebral atrophy 5. 8%.


Input: The effects of contrast media on coagulation factor XII.

coagulation factor XII


Input: Pigs were switched from the growing to the finishing diet at 57 and 61 kg in Exp.


Input: In sixteen patients with moderate essential hypertension the effects of 10-day nifedipine treatment on serum uric acid and renal excretion of uric acid were evaluated.


Input: TPTA produced brain congestion, and hepatic and pulmonary petechial and generalized hemorrhages.


Input: Examples are using more subjects or an improved research design, developing consensus statements or using meta-analysis.


Input: A two phase slug flow tubular heat exchanger was used for the thermal inactivation of Listeria monocytogenes in natural infected milk from seven cows.


Input: So far 15 children have been studied.


Input: Regional cerebral blood flow (rCBF) measurements and psychiatric ratings were performed on seven schizophrenic patients (mean age = 41. 4 years) who had been examined 18 years previously in a study that used similar psychiatric ratings and a comparable rCBF technique.


Input: In the present study, we identified a strong positive cis-regulatory element at-70 bp to-75 bp in the LpS1 beta promoter with the sequence (G) 6 and a similar, more distal cis-element at-721 bp to-726 bp.

LpS1 beta promoter


Input: No case of SMF demonstrated expansive tumorous growth.


Input: Different doses of 15-methyl-PGF2 alpha (0. 125-10 mg) were used to induce luteolysis and oestrus in 7 heifers with 28 treatments on day 8-12 of the oestrous cycle.


Input: Review of the literature and report of a case of a dermoid cyst.


Input: Resolution of thermographic asymmetry and/or decrease in Delta T was demonstrated in approximately 81% of the post-treatment population.


Input: Maize rbcS promoter activity depends on sequence elements not found in dicot rbcS promoters.

Maize rbcS promoter

dicot rbcS promoters


Input: Measurements were done with a commercial haematofluorometer Buchler ZF which was calibrated to the average haematocrit value of 0. 42.


Input: The relatively scanty number of examples, which could be justified by the variety and complexity of combined exposure, allows to conclude that life-style factors have considerable influence on interindividual differences in susceptibility to xenobiotics toxicity.


Input: The 12S E1A product does not activate a TRE sequence, but cotransfection with c-jun circumvents this lack of stimulation.

12S E1A product

c-jun


Input: After treatment with tunicamycin, the transfectants secreted unglycosylated 18-kDa polypeptides which could also bind IgE.

IgE


Input: PAS1, a yeast gene required for peroxisome biogenesis, encodes a member of a novel family of putative ATPases.

ATPases


Input: The pp90rsk-protein kinase activity (referred to as rsk-kinase) is also not related to cofactor-dependent signal transducing protein kinases such as the cyclic AMP-dependent protein kinases, members of the protein kinase C family, or other Ca2 (+)-dependent protein kinases.

pp90rsk-protein kinase

rsk-kinase

cyclic AMP-dependent protein kinases

protein kinase C family

Ca2 (+)-dependent protein kinases


Input: Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene.

Human GATA-3

T cell receptor alpha gene


Input: Like many eukaryotic transcription factors, these proteins bind to DNA as dimers.


Input: Furthermore, the UvrA protein interacts with the UvrB protein to modulate its activities, both in solution and in association with DNA, where the UvrAB complex possesses a helicase activity.

UvrA protein

UvrB protein

UvrAB complex

helicase


Input: The ED30 values were 2. 4 and 2. 2 mg/kg and similar to the respective values of nifedipine (ED 30: 2. 4, 2. 1 mg/kg).


Input: Southwestern blot analysis demonstrated that this phosphoprotein can bind the kappa B element directly and specifically.

kappa B element


Input: The minus-end-directed microtubule motors, the dyneins, may also constitute a superfamily of force-generating proteins with distinct attachment domains.

dyneins


Input: The incompatibility group W plasmid pSa suppresses Agrobacterium tumefaciens oncogenicity (J.


Input: Potential translational start signals are upstream of ORF1 and ORF2.


Input: Imaging of D2 dopamine receptor


Input: The abundance of transcripts from several unrelated genes is decreased in cdc68-1 mutant cells after transfer to the restrictive temperature, while at least one transcript, from the HSP82 gene, persists in an aberrant fashion.

cdc68-1 mutant

HSP82 gene


Input: The murine Mov-34 gene: full-length cDNA and genomic organization.

murine Mov-34 gene


Input: CREB was identified as one of the protein components in several of the gel shift complexes formed with the variant CRE.

CREB


Input: The spectrum of histologically diagnosed malignant neoplasms in Sabah, 1983-1988.


Input: When transfected into Drosophila SL-2 cells, pCAT plasmid containing 2, 090 bp of 5'-flanking region shows a 3. 0-to 3. 5-fold increase in chloramphenicol acetyltransferase activity after induction with retinoic acid and/or 8-bromo-cAMP.

chloramphenicol acetyltransferase


Input: Two alternatively spliced 5' UTRs, designated type I and type II, of 222 and 115 bp, respectively, were found associated with PFP.

PFP


Input: The N-terminus of another open reading frame was found 3' from nifA and tentatively identified as nifB by amino acid sequence comparison.

nifA

nifB


Input: The RNA genome of rabbit hemorrhagic disease virus (RHDV) was molecularly cloned.


Input: Therefore, we have developed a system to study nuclear targeting in plants and have established that the nuclear transport machinery is similar in monocots and dicots.


Input: A novel cDNA clone termed R2 was isolated by subtractive hybridization of a cDNA library of phytohemagglutinin (PHA)/phorbol myristate acetate-stimulated Jurkat cells and by rescreening a cDNA library of PHA-stimulated peripheral blood lymphocytes.

phytohemagglutinin

PHA


Input: Chagas' disease, visceral leishmaniasis, anti-nuclear factor, schistosomiasis, rheumatoid factor and normal controls.

anti-nuclear factor

rheumatoid factor


Input: The second transcriptional unit, designated UL26. 5, predicted to specify a protein of 329 amino acids, encodes the family 35 proteins; it is transcribed by an mRNA which initiates at approximately nucleotide + 1000 of the UL26 transcription initiation site and is translated from the methionine initiation codon located at position + 1099 of the UL26 transcriptional unit.

UL26. 5

family 35 proteins

UL26 transcriptional unit


Input: The adeno-associated virus (AAV) rep gene encodes four proteins (Rep78, Rep68, Rep52, and Rep40) required for AAV DNA replication and AAV gene regulation.

adeno-associated virus (AAV) rep gene


Input: A larger region upstream of human CMV dbp also mediated replication in transient assays.

human CMV dbp


Input: It also contains a picornaviral 3C-like protease domain and two papain-like protease domains.

picornaviral 3C-like protease domain

papain-like protease domains


Input: However, the relative positions of the VV genes (genus Orthopoxvirus) are different than those of the corresponding ORFs in SFV (genus Leporipoxvirus), indicating complex rearrangements of DNA in the genome of one or both of these viruses subsequent to their divergence from a common ancestor.


Input: This result suggests that phosphorylation of Thr 14 and/or Tyr 15 inhibits p34cdc2 kinase activity, in line with the location of these residues within the putative ATP binding site of the kinase.

p34cdc2 kinase


Input: In short-term cotransfections, a pFRTK-CAT target containing EBNA-1-binding sites from the EBV origin of plasmid replication, ori-P, was transactivated by a carboxy-terminal EBNA-1 construction (amino acids 450 to 641) that also carried a c-myc nuclear localization signal.

pFRTK

CAT

EBNA-1-binding sites

ori-P

carboxy-terminal EBNA-1 construction

c-myc nuclear localization signal


Input: The findings are compatible with the idea that the genes encoding PDGF receptors in glioma cells are regulated in concert with other genes, the expression of which may reflect the developmental program of normal glia cell lineages.

PDGF receptors


Input: Suggestive evidence was obtained that cstA is involved in peptide utilization.

cstA


Input: This study tested the hypothesis that sodium channel blocking drugs selectively prolong the late potential, or terminal low amplitude signal, portion of the signal-averaged QRS complex and that prolongation of the late potential would correlate with slowing of ventricular tachycardia.


Input: Identification and nucleotide sequence of Rhizobium meliloti insertion sequence ISRm3: similarity between the putative transposase encoded by ISRm3 and those encoded by Staphylococcus aureus IS256 and Thiobacillus ferrooxidans IST2.

Rhizobium meliloti insertion sequence ISRm3

transposase

Staphylococcus aureus IS256

Thiobacillus ferrooxidans IST2


Input: To determine the relationship of these viruses, the complete DNA sequence of KV consisting of 4754 bp was determined.


Input: Whereas a PR55 beta transcript of about 2. 3 kb was detected at high levels in the neuroblastoma derived cell line LA-N-1, the level of the mRNA was very low in the other human cell lines analyzed.

PR55 beta transcript


Input: Heterodimers of myogenin and E12 (or MyoD and E12) specifically bound a restriction fragment extending from-200 to-103 relative to the start of cardiac alpha-actin transcription.

myogenin

MyoD

cardiac alpha-actin


Input: The effects of c-myc were further dissected by showing that c-myc can inhibit differentiation independently of Id, a negative regulator of muscle differentiation.

c-myc

c-myc

Id


Input: Stable association of U2 snRNP with the branchpoint sequence of mammalian pre-mRNAs requires binding of a non-snRNP protein to the polypyrimidine tract.

U2 snRNP


Input: The Italian Lung Cancer Task Force (FONICAP).


Input: The promoter activity of the gene encoding Alzheimer beta-amyloid precursor protein (APP) is regulated by two blocks of upstream sequences.

gene encoding Alzheimer beta-amyloid precursor protein

APP


Input: This element was used to screen an EMBL3 mouse genomic library.


Input: The MVV-value is under the predicted level in the case of 67-76 percent.


Input: The rad9. 192 DNA repair mutant from the fission yeast, Schizosaccharomyces pombe, is sensitive to both UV and ionising radiation.

rad9. 192 DNA repair mutant from the fission yeast, Schizosaccharomyces pombe


Input: Review: deterioration of glucose tolerance with age: the role of insulin resistance.

insulin


Input: The 5' region shows strong sequence similarity to Escherichia coli consensus promoters and ribosome-binding sequences and allows high levels of expression in E. coli.


Input: Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase.

GTPase


Input: The method has been routinely used in our laboratory for 1 year and has proven to be a reliable procedure for the biological control of occupational exposure to toluene and/or xylene.


Input: The patient was a 78-year-old male in whom skin lesions preceded the diagnosis of myelofibrosis.


Input: Oculus-500 is a group of high resolution imaging boards for use with IBM-AT and compatible computers.


Input: After resection of the proximal fragment, all scaphoid contact area and pressure was born by the distal scaphoid fragment.


Input: Plate luting, a technique that uses polymethylmethacrylate (PMMA) interposed between the plate and the bone, as well as between the screw heads and the plate, to improve the stability of internal fixation was tested in vitro using 20 paired equine third metacarpal bones with mid-diaphyseal osteotomies plated with six-hole broad ASIF compression plates.


Input: These features were considered consistent with a diagnosis of Rothmund-Thomson syndrome.


Input: Thyroid lymphoma and its management.


Input: The protein encoded by ORF113 contains a transmembrane domain.


Input: Space limitations prevent an exhaustive review of all biologic pharmaceuticals, such as tissue plasminogen activating substance, hormones (e. g., thyroid, insulin, growth hormone, erythropoietin), clotting factors, and blood products.

tissue plasminogen activating substance

insulin

growth hormone

erythropoietin


Input: The various forms of sickle cell disease share the common feature of an abnormal globin chain that, under certain conditions such as hypoxia, results in the sickling of red blood cells and obstruction of blood vessels.

globin chain


Input: The primary structure of each of the three proteins has about 70% homology with that of mouse contrapsin, in contrast to 43-46% homology with that of rat alpha 1-protease inhibitor.

mouse contrapsin

rat alpha 1-protease


Input: Patterns of connections underlying cross-modality integration were studied by injecting distinguishable, retrograde tracers (Fluoro-Gold and diamidino yellow) in pairwise manner into different sensory representations (visual, somatosensory, and auditory) in the cerebral cortex of the rat.


Input: The across-fiber pattern of the responses to hypotonic NaCl solutions correlated strongly to that elicited by distilled H2O. (ABSTRACT TRUNCATED AT 400 WORDS)


Input: Human immunodeficiency virus type 1 (HIV-1) IN, expressed in Escherichia coli, was purified to near homogeneity.

Human immunodeficiency virus type 1 (HIV-1) IN


Input: Thigh girth correlated positively with HDL and HDL2-C and mass, and with LDL particle size among women.

HDL

LDL


Input: Contributions from pairs of source and target volume elements are summed for the S values between the tumor and itself, between the remaining healthy host organ and itself, and between the tumor and the remaining healthy host organ, with the reciprocity theorem assumed for the last.


Input: Tests showed that an overall impression of the force applied could be obtained from a laboratory simulation, but that clearing cement and testing cement were not modelled by this method.


Input: The cDNA contained an open reading frame of 1392 bp that predicted a protein of 464 amino acids and a molecular mass of 52 kDa; this protein has 97% identity to rat liver glucokinase.

rat liver glucokinase


Input: Analysis of viral mutants in vivo demonstrated that the NFIII/OCT-1 binding site and a conserved ATF motif were important for efficient viral growth.

NFIII

ATF motif


Input: Recovery of radiolabelled BA through urine (28%) and faeces (22%) up to 96 hrs averaged 50%, whereas residual radioactivity in liver and testis experienced a recovery of 29% in scorbutic animals.


Input: Paradoxically, however, the GH receptor cloned from liver exhibits no sequence similarity to receptors with known signal transduction mechanisms, including those exhibiting ligand-activated tyrosine kinase activity.

GH receptor

tyrosine kinase


Input: This indicates that under certain experimental conditions cdc2/p58 and cdc2/p62 may express some differences in their catalytic activity.


Input: Mutation analysis implicated multiple segments of the 5' untranslated region as contributing to the inhibitory effect.


Input: Identification of Ets-and notch-related subunits in GA binding protein.

Ets

notch

GA binding protein


Input: The enzymatic response of neutrophils and monocytes was similar although the magnitude of the NADPH oxidase activity was significantly higher in neutrophils than in monocytes.

NADPH oxidase


Input: In the ileum, enterotoxin increased the luminal disappearance (P less than 0. 05) and peripheral blood appearance (P less than 0. 001) of chloroquine.


Input: It is concluded that attention to these issues can substantially improve the quality of research on AIDS related behaviors on Black communities.


Input: The effectiveness of alpha-mercapto-beta-(2-furyl) acrylic acid (MFA) and N-benzyl-N-dithiocarboxy-D-glucamine (NaB), used in combination, in the mobilization and excretion of lead was investigated in rats.


Input: These results suggest that beta-1 may act as a tissue-specific, trans-acting regulator of the expression of the beta-zein gene in developing maize endosperm.

beta-zein gene


Input: This study examines the effects of hypovolemia on the extracellular ptO2 and ptH distributions at multiple tissue sites using a recently developed multipoint microelectrode, that provides simultaneous measurements of ptO2 and ptH.


Input: All members are also capable of activating in vivo transcription from promoters that contain a C/EBP-binding site.

C/EBP-binding site


Input: The domains involved in superactivation appear to be a subset of those necessary to achieve synergistic activation.


Input: Information on conserved noncoding sequences will help in studies on the regulation of the pro alpha 1 (II) collagen gene.

pro alpha 1 (II) collagen gene


Input: Chlamydia trachomatis and Chlamydia psittaci were not affected by methanol fixation.


Input: Although human infections with bacteraemia due to Pasteurella multocida are not uncommon, endocarditis associated with P. haemolytica is rare.


Input: For SMX at pH 7. 0, a 1: 1 complex is formed, but at pH 7. 5 HPCD has little effect on the solubility of the highly ionized SMX, presumably since only un-ionized molecules can form inclusion complexes with the HPCD.


Input: PO2 measurements using a double barrelled recess type microelectrodes were measured in the optic nerve head of miniature pigs in normoxia and hyperoxia.


Input: POU-specific and POU-homeo domains of Oct3 were produced in Echerichia coli for characterization of DNA binding to the octamer sequence.

POU

POU


Input: The nucleotide (nt) sequences of the exons, exon/intron boundaries and 5'-and 3'-untranslated regions were determined.


Input: Out of 40 patients, who initially did not show eye complications due to leprosy, 37 patients were essentially the same 10 years later.


Input: Thus, two very different regulatory elements are used to mediate estrogen induction of related genes in chickens and amphibians.


Input: Experimentally in green monkeys, Syrian hamsters and white mice the authors studied the pathogenic properties of a new virus Issyk-Kul.


Input: Increasing mean arterial pressure by phenylephrine infusion to levels much greater than produced by NMA and NNA caused only small reductions in cardiac output.


Input: J.


Input: With stepwise reductions in flow, the peak (S) and trough (D) points of the maximum shifted-frequency envelope fell in parallel in a linear fashion until D reached zero.


Input: The IE0 gene product also transactivated the IE1 promoter but did not affect expression from its own promoter.

IE0 gene

IE1 promoter


Input: Evaluation of left ventricular function using gated planar myocardial imaging with Tc-99m-MIBI


Input: Bone marrow abnormalities in Hodgkin' s disease are reviewed and the current understanding of the pathological mechanisms leading to aplastic anemia is discussed.


Input: The smaller uptake rate and faster clearance rate resulted in the lower BCF for SWA killifish.


Input: Increases in the perfusate PCO2 but not in the perfusate H + were highly correlated with decreases in both myocardial contractility and oxygen consumption (r2 =. 88).


Input: Expression was cell cycle controlled, with steady-state RNA levels significantly higher in growth-arrested than in growth-stimulated cells.


Input: Determinants of recurrent ischaemia and revascularisation procedures after thrombolysis with recombinant tissue plasminogen activator in primary coronary occlusion.

tissue plasminogen activator


Input: Therefore, the rbcL-rbcS locus seems to be barely expressed under a standard condition for photoautotrophic growth.

rbcL

rbcS


Input: Relationship between mitochondrial NADH-ubiquinone reductase and a bacterial NAD-reducing hydrogenase.

mitochondrial NADH-ubiquinone reductase

bacterial NAD-reducing hydrogenase


Input: Analysis of mRNA expression shows that AT-BP1 and AT-BP2 are expressed in all the tissues examined.


Input: 3 cases


Input: Sequence requirements for premature transcription arrest within the first intron of the mouse c-fos gene.

mouse c-fos gene


Input: Infarct regional ejection fraction improved by 10. 1 +/-2. 1% between early and late studies when the infarct-related artery was patent and by 4. 8 +/-1. 4% if it was occluded (p = 0. 048); changes in global and noninfarct regional ejection fraction were similar irrespective of perfusion status.


Input: One of its lysine residues is modified by spermidine to form hypusine, a posttranslational modification unique to eIF-5A.


Input: The plasmid shuffle technique was used to replace the wild-type gene with the mutant form, resulting in failure of the yeast cells to grow.


Input: If this is the case, identification and characterization of transcripts from the Ig loci should permit a better understanding of the gene rearrangement process.

Ig loci


Input: Transcription of the metH gene in Salmonella typhimurium and Escherichia coli is positively regulated by the metR gene product, a DNA binding protein.

metH gene in Salmonella typhimurium and Escherichia coli

metR gene product


Input: Disruption of the chromosomal AAR1 gene in alpha and a/alpha cells conferred the nonmating phenotype, and the a/alpha diploids could not sporulate.

chromosomal AAR1 gene


Input: The effect of ICRF-187 on the antitumor response induced by the combination of ADR and WBH was also investigated in order to assess alterations in the therapeutic index of this combined therapeutic modality treatment.


Input: The ORF was analyzed for secondary structural features, and the sequence data bases were searched for homologies.


Input: Mitomycin-C can cause severe necrosis and ulceration when extravasated inadvertently into skin and soft tissues following IV drug administration.


Input: In this study, we have cloned the 5'-flanking region of the human nidogen gene.

human nidogen gene


Input: Consistent with the in vivo result, the pseudorevertant endonucleases in the crude cell extract display site-specific partial DNA cleavage activity.


Input: Additionally, I kappa B beta, but not I kappa B alpha, also prevented the binding of Rel to the kappa B site.

I kappa B beta

I kappa B alpha

Rel

kappa B site


Input: Sequence analysis reveals that the DNA binding domain of ILF has strong homology to the recently described fork head DNA binding domain found in the Drosophila homeotic protein fork head and a family of hepatocyte nuclear factors, HNF-3.

ILF

fork head DNA binding domain

Drosophila homeotic protein fork head

hepatocyte nuclear factors


Input: Lengthy and repeated hemodialyses were required to lower lithemia to nontoxic ranges.


Input: A single i. p. injection of d, l-baclofen 10 mg/kg both reduced noradrenaline (NA) biosynthesis in vivo (31%) and the endogenous concentration of normetanephrine (NMN) (32%) and increased NA levels (28%).


Input: Fufang wuzi yanzong pills have strong leukogenic effect on cyclophosphamide induced leukopenia in mice.


Input: Mutations in the small subunit of ribulosebisphosphate carboxylase affect subunit binding and catalysis.

ribulosebisphosphate carboxylase


Input: The structural changes in intra-acinar artery manifested mainly by an increase in number of muscular artery resulting from muscularization of precursor cells (pericytes and intermediate cells) located within partially muscular and nonmuscular arterial wall to smooth muscle cell, and by the medial wall thickened due to hypertrophy and hyperplasia of smooth muscle cells as well as accumulation of a large amount of collagen, especially the type 1 collagen.

collagen

type 1 collagen


Input: These results suggest that NZ-107 may be a useful drug for the treatment of bronchial asthma by reducing late-phase airway responses and airway hyperreactivity.


Input: In study 2, the correlation coefficients between the ISO2 measurements obtained at the ulcer margin and at the adjacent normal mucosa, and delta ISO2 obtained by the experienced observer and one of the three learners were 0. 94, 0. 97, and 0. 94, respectively.


Input: Bronchial mucosa tattooing in persons exposed to different industrial aerosols did not depend on the forms of PC, DB and the diseases' stages.


Input: Anti-HBc production of PBMC was enhanced remarkably in this case.

Anti-HBc


Input: Lipoprotein lipase (LPL), a key enzyme in normal lipoprotein metabolism, has a complex pattern of regulation and tissue-specific expression.

Lipoprotein lipase

LPL


Input: Deletion of the proximal octanucleotide motif from the plasmid containing the-461 fragment of the LPL promoter, resulted in a 79 and 76% decrease in the level of expression in transfected 3T3-L1 adipocytes and HepG2 hepatocytes, respectively.

LPL promoter


Input: We examined the binding of purified T3 receptor alpha (T3R alpha), overexpressed in Escherichia coli, to wild-type and up and down mutations of the rGH T3RE to evaluate whether transcriptional potency correlates with changes in T3R binding.

T3 receptor alpha

T3R alpha

rGH T3RE


Input: Comparison of the cDNA-predicted avian TnIcardiac amino acid sequences with known TnI sequences indicated 1) that the presence of an N-terminal extension sequence carrying a dual protein kinase A phosphorylation target site and an adjacent proline-rich segment is an ancient cardiac-specific feature of TnI which has been conserved since the bird/mammal divergence, 2) that features of the near-N-terminal troponin C (TnC)-binding site sequence suggest isoform-specific adaptation of TnI and TnC, and 3) that the avian TnIcardiac internal actin/TnC-binding, actomyosin-inhibitory, domain shows significant sequence divergence from mammalian TnIcardiac sequences, including the absence of a protein kinase C target site which is a cardiac-specific feature of TnI in mammals.

avian TnIcardiac amino acid sequences

TnI sequences

protein kinase A

TnI

troponin C

TnC

TnI

TnC

TnIcardiac

actin/TnC-binding, actomyosin-inhibitory, domain

mammalian TnIcardiac sequences

protein kinase C

TnI


Input: Ventilatory management casebook.


Input: An ASSEMBLER routine for on-line graphic display and averaging of data acquired on a personal microcomputer.


Input: Expression of the mouse TSH beta gene, therefore, gives rise to multiple mRNAs, each with a unique 5'-untranslated region.

mouse TSH beta gene


Input: It was found that the ROSP undergoes a number of fluctuations in the negative and positive directions with a gradually decreasing amplitude in the course of 5-25 days following the operation, after which relatively stable negative values of the ROSP are established on the average in electrodes implanted to the level of the dura mater, and positive values in electrodes implanted to the level of the pia mater.


Input: Blood flow velocity waveforms were recorded by pulsed Doppler examination of the fetal internal carotid and middle cerebral arteries using the established transabdominal route as well as a new transvaginal approach.


Input: Quantitative analysis of DNA using flow cytometry and immunocytochemical findings in 16 cases of cardiac myxomas


Input: Sequence analysis revealed that in addition to the non-spliced variant, multiple mRNA species were generated by alternative splicing resulting in the exclusion of 92, 166, 170, 174 and 263 nucleotides (nt), respectively, from exon 1.


Input: Position 22 is an isoleucine in the complete SsoL12 protein sequence, coded by an AUA codon.

complete SsoL12 protein sequence


Input: Symptoms due to the action of mastocyte mediators were observed.


Input: In the yeast Saccharomyces cerevisiae, copper levels exert some control over the level of SOD1 expression.


Input: Of these 179 samples, Mobiluncus SP was observed in 35 (19. 6%) using Gram staining and in 18 (10. 1%) this microorganism was isolated in agar RLK and anaerobic atmosphere.


Input: Previous investigators have suggested that subretinal blood damages the retina in part because of its solid fibrin meshwork.

fibrin


Input: Twenty-four hours later, the animals were randomized to subretinal treatment with 2. 5 micrograms of tissue plasminogen activator or a similar volume of physiologic saline.

tissue plasminogen activator


Input: Neuro-otological examinations revealed spontaneous downbeat nystagmus, bilateral gaze nystagmus and rebound nystagmus.


Input: Since the morphology of the lesions can mimic that of other cutaneous disorders, Bowen' s disease is often not recognized initially.


Input: Equine amnion and live yeast cell derivative were evaluated as a biological dressing and as a topical wound medicament respectively, in the treatment of granulating wounds of the distal portion of the limbs of horses.


Input: To lower the current high incidence of NANB-induced PTH, in 1986, the American Association of Blood Banks (AABB) recommended testing for these PTH-associated " surrogate " markers on all donated units of blood.


Input: Fusion of ubiquitin to pADPRP increased the yield of pADPRP approximately 10-fold compared to that of the unfused enzyme.

ubiquitin

pADPRP

pADPRP


Input: In group III, patients also received their own mediastinal drainage blood, shed for 6 hours after operation, after concentration and washing in a MBRS.


Input: The effect of salmon calcitonin nasal spray in women with established osteoporosis has also been studied.

salmon calcitonin


Input: Skeletal muscle metaboreceptor responses are impaired in heart failure.


Input: Skeletal muscle metaboreceptor exercise responses are attenuated in heart failure.


Input: Evaluation of antiepileptic drug effect on membrane fluidity.


Input: The examinations were performed on two groups of 20 (using AmF/SnF2)-, resp.


Input: The vaccine used was known to be immunogenic for older children and adults.


Input: Both groups then underwent hypnotic induction, and completed the test again (R2).


Input: Applications of three-dimensional analysis to the auditory P300.


Input: The construct was introduced into BW2001 (xth-11, nfo-2) strain cells of Escherichia coli.


Input: Recombinant human TFIID supported weak basal transcription in heat-treated nuclear extracts whereas a partially purified TFIID fraction from HeLa cells reconstituted a maximal level of transcription.

Recombinant human TFIID

TFIID


Input: Only after a pretreatment aimed at increasing its oxide surface layer was titanium powder found to accelerate the precipitation from solutions containing 2 mmol/L CaCl2, 2 mmol/L KH2PO4, 50 mmol/L Hepes, pH 7. 2, and to induce precipitation from metastable solutions containing 1. 2 mmol/L CaCl2, 1. 2 mmol/L KH2PO4, 50 mmol/L Hepes, pH 7. 2, at 37 degrees C.


Input: We conclude that solidification could occur in all feeds containing casein and that alternative feeds should be considered in patients with increased gastric acidity.

casein


Input: Neither model, as applied, provided a satisfactory account of the effects of the main variables of number of tones and amount of perturbation. (ABSTRACT TRUNCATED AT 400 WORDS)


Input: Determination of an RNA structure involved in splicing inhibition of a muscle-specific exon.


Input: Endothelial cells stored with University of Wisconsin solution excluded trypan blue better (1. 0% +/-0. 5% cells stained, p less than 0. 001.


Input: The effect of diffusion limitation was quantified in terms of the ratio O2 uptake/O2 requirement (= fraction of cross-sectional area supplied with O2), assuming local O2 requirement per unit volume to be constant and independent of PO2 at PO2 greater than 0.


Input: (2) Diffusion limitation in the heterogeneous model sets in at a lower O2 requirement value, and increases more gradually with increasing O2 requirement, than in the corresponding homogeneous models with the same average cylinder diameter.


Input: The antihypertensive effect of Estulic has been examined over a 12-month period in 101 hypertensive patients.


Input: At the time of the seizure, the patient was asked to read a test phrase aloud until it was read correctly and clearly.


Input: Monitoring patients with acute leukemia for IL-1 and TNF levels throughout the clinical course of disease may help clarify the causes of febrile episodes.

TNF


Input: Echinococcus granulosus was diagnosed by fine-needle aspiration cytology of a lung cyst in a 6-yr-old white female in central Missouri.


Input: The sequence was determined of 6493 nucleotides encompassing the bet genes of Escherichia coli which encode the osmoregulatory choline-glycine betaine pathway.

bet genes of Escherichia coli


Input: A 7-day treatment of amphotericin B (5 mg/kg/day i. p.) significantly reduced the glomerular filtration rate (GFR) measured as inuline clearance and creatinine clearance (0. 74 +/-0. 29 and 0. 16 +/-0. 04 ml/min, respectively) in comparison to vehicle-treated rats (2. 04 +/-0. 23 and 1. 29 +/-0. 19 ml/min, respectively).


Input: Confocal fluorescence microscopy in modern cell biology.


Input: Toluene is the chemical most frequently present in cases involving volatile solvents.


Input: Fortunately DDT-, HCH-and HCB-levels decreased in breast milk during the last years.


Input: A herpesvirus proteinase activity has been identified and partially characterized by using the cloned enzyme and substrate genes in transient transfection assays.


Input: Adult H, but not R, manifested the burrowing preference whenever offered the opportunity.


Input: The rear silver liquid chamber was threefold thick to 17 MeV protons in water and it efficiently produced either 13N by the 16O (p, alpha) 13N reaction or [18F] fluoride ion by the 18O (p, n) 18F reaction.


Input: Heterogeneous electron transfer of cytochrome c facilitated by polypyrrole and methylene blue polypyrrole film modified electrodes.

cytochrome c


Input: Selective activation of adrenaline secretion by the rat adrenal in neuroglycopenia detected via microdialysis


Input: The 1489-base pair EFIA cDNA encodes a 322-amino acid protein which is nearly identical to two previously described human DNA binding proteins.

EFIA


Input: Four putative positive cDNA clones were isolated, and the largest insert (pASB-1) was sequenced in both orientations.


Input: Sci.


Input: Dose standardisation of botulinum toxin.

botulinum toxin


Input: The coding sequence for a 260-amino-acid residue polypeptide was interrupted by a single short intron of 60 base pairs (bp), and about 70% of the deduced amino acid sequence of the Drosophila PCNA was identical to the rat and human PCNA polypeptides, with conserved unique repeats of leucine in the C-terminal region.

Drosophila PCNA

human PCNA polypeptides


Input: Translational fusions of the aroF regulatory regions to lacZ were constructed and then introduced in single copy into the E. coli chromosome. beta-Galactosidase assays for tyrR-mediated regulation of aroF-lacZ expression revealed that the E. coli TyrR repressor apparently recognizes the operators of both organisms with about equal efficiency.

aroF regulatory regions

lacZ

beta-Galactosidase

aroF

lacZ

E. coli TyrR repressor


Input: During exercise K + is released from contracting muscle and plasma K + concentration rises.


Input: Following treatment, serum estradiol levels were higher in groups E + T and E than in group C.


Input: We conclude that the beta-adrenergic agonist, isoproterenol, has little influence on vascular capacitance or liver volume of dogs, unless the hepatic outflow resistance is elevated by agents such as histamine.


Input: DNA sequence and evolution of the CPS domain of the Syrian hamster multifunctional protein CAD.

CPS domain

Syrian hamster multifunctional protein CAD


Input: A high-frequency restriction fragment length polymorphism was evident in the DNA from 29 unrelated individuals using the enzyme BglII.

BglII


Input: The antilog transformation of pH did not improve the results.


Input: Telomeres prevent end-to-end fusions and exonucleolytic degradation, enable the end of the linear DNA molecule to replicate, and function in cell division.


Input: One of these is located in the 5'-untranslated region, and may encode regulatory sequences.


Input: The native enzyme purified from protease-B-deficient URA2-transformed cells, was phosphorylated in vitro using catalytic subunits of pure cAMP-dependent protein kinase.

protease-B

cAMP-dependent protein kinase


Input: A bovine abomasum lambda gt11 cDNA library was screened with a monoclonal antibody raised against the rabbit H, K-ATPase beta subunit.

rabbit H, K-ATPase beta subunit


Input: Judicious use of laboratory testing, including monitoring of CD4 cell counts, is recommended.


Input: There is no TATA box appropriately spaced upstream from the transcription initiation site.


Input: Characterization of the 5' end of the growth-regulated Syrian hamster CAD gene.

Syrian hamster CAD gene


Input: Early cirrhosis, an early modality of the evolution of acute hepatitis.


Input: Combined therapy with MK-801 and nimodipine for protection of ischemic brain damage.


Input: Initial screening of a rat liver cDNA library with an oligonucleotide probe derived from the rat SCP2 protein sequence revealed an 825-base pair cDNA clone coding for the complete SCP2 protein sequence.


Input: Cloning, expression, and nucleotide sequence of rat liver sterol carrier protein 2 cDNAs.

rat liver sterol carrier protein 2 cDNAs


Input: The addition of an equimolar complex of the fourth and seventh largest subunits, purified from pol II holoenzyme by ion-exchange chromatography in the presence of urea, restored promoter-directed initiation activity to pol II delta 4/7.

pol II holoenzyme

pol II delta 4/7


Input: We report here the identification of HSF in the fission yeast Schizosaccharomyces pombe.

HSF


Input: Induction requires the ACE1 gene product, which binds to specific sites in the promoter region of the CUP1 gene.

ACE1 gene product

CUP1 gene


Input: Gel mobility shift assays using a synthetic E6 motif detected a B-cell-specific complex in addition to a ubiquitous band found also in T cells and HeLa cells.

E6 motif


Input: The sequence of four clones was sufficient to construct a 3018-bp BAL cDNA structure.

3018-bp BAL cDNA


Input: The application of these instruments allows occlusion of the ascending aorta traversed by the perfusion cannula inserted directly or through the apex of the heart as well as simultaneous left ventricular venting.


Input: Adenylosuccinate synthetase (IMP: L-aspartate ligase (GDP), EC 6. 3. 4. 4) plays an important role in purine biosynthesis catalyzing the GTP-dependent conversion of IMP to AMP.

Adenylosuccinate synthetase

L-aspartate ligase

EC 6. 3. 4. 4


Input: Immunophenotyping in four cases, demonstrated non-B, non-T cell origin in three and pre-B cell origin in one.


Input: The results strengthen the conclusion that predominantly dynamic activity increases the G4 content of mature innervated fast muscles.


Input: We reviewed the records of 151 patients with optic neuritis examined over an eight-year period.


Input: Cut-off levels that define abnormality are rather arbitrary and this decreases the specificity of the test in apparently healthy patients.


Input: Alanine aminotransferase in clinical practice.

Alanine aminotransferase


Input: Nucleotide sequence analysis of the Pseudomonas putida PpG7 salicylate hydroxylase gene (nahG) and its 3'-flanking region.

Pseudomonas putida PpG7 salicylate hydroxylase gene

nahG


Input: All six ARF cDNAs are more similar to each other than to other approximately 20-kDa guanine nucleotide-binding proteins.

ARF cDNAs

20-kDa guanine nucleotide-binding proteins


Input: The long terminal repeat (LTR) of the human immunodeficiency virus (HIV) contains three binding sites for the transcriptional factor Sp1.


Input: DNA from PCR was labeled and used to isolate several lambda gt11 cDNA clones, including one full-length one (Dd kinase-2).

Dd kinase-2


Input: A.


Input: Perilunar luxation--an unusual injury demanding immediate and correct treatment


Input: Landsberg (La-O) and cv.


Input: In summary, at equianesthetic concentrations, desflurane and isoflurane produced similar hemodynamic effects; however, in the absence of drugs that inhibit autonomic reflexes, desflurane had less negative inotropic activity and produced less decrease in arterial pressure.


Input: We report here the isolation of a full-length cDNA clone coding for a hitherto undiscovered isoform of the bovine C-subunit.

bovine C-subunit


Input: Isoform C beta 2, an unusual form of the bovine catalytic subunit of cAMP-dependent protein kinase.

Isoform C beta 2

cAMP-dependent protein kinase


Input: Salient applications of PB-PK modeling to toxicological problems are illustrated with examples.


Input: Patients with apparently minor CT abnormalities may have significant epidural disease.


Input: The cdr1 sequence includes an additional 237 amino acids of the contiguous fragment and encodes a product of predicted Mr 67, 000.

cdr1 sequence


Input: Armed with a clear understanding of the pathophysiologic pathways that may cause and/or contribute to the development of unconjugated hyperbilirubinemia and the associated jaundice, the practitioner will be successful in helping the family understand their child' s illness.


Input: Displacement thresholds of peripheral sites in monocular human vision were obtained.


Input: The authors report a case in which stereotactic irrigation of a brain cyst was temporally associated with respiratory distress.


Input: ELISA was found to make a contribution to the diagnosis of tuberculosis similar to that of sputum smear.


Input: In this paper, we report a detailed study of the structure and the functional role of the MalT binding sites located in the adjacent and divergent pulAp and pulCp promoters.

MalT binding sites

pulAp

pulCp promoters


Input: Despite the small number of patients, on the basis of this report, we can confirm that 1. 5 MU/day of alpha-IFN is an adequate treatment for patients with hairy cell leukemia.

alpha-IFN


Input: Paroxysmal fluctuations in observed parasitemia in Plasmodium falciparum malaria.


Input: No positive family history was obtained.


Input: Occupational asthma and rhinoconjunctivitis from inhalation of crystalline bovine serum albumin powder.

bovine serum albumin


Input: A further subdivision of Category pN1 into pN1a (metastasis in single node) and pN1b (two or more nodes) is recommended.


Input: Amino acid sequence comparisons of the E74A protein reveal a highly conserved C-terminal region that is rich in basic amino acid residues and which has been proposed to possess sequence-specific DNA binding activity.

E74A protein


Input: We found that the relative strengths of the promoters were similar in different contexts.


Input: Grasso, and A.


Input: After 6 months, definite improvement in strength occurred in 4 of 7 carnitine-treated patients and in none of 7 controls.


Input: Age at POI and asymptote were achieved later for Line RBC2 than for Line F.


Input: To identify the DNA sequences that cis-regulate the expression of the rat liver pyruvate kinase (L-PK) genes, a series of constructs in which the chloramphenicol acetyltransferase reporter genes is driven by various deleted fragments of the 3200 base pairs (bp) upstream of the L-PK gene cap site have been assayed for transient expression after introduction into hepatoma HepG2 cells, rat hepatocytes in primary culture, fibroblast LTK-cells, myogenic C2C12 cells, and CHO cells.

rat liver pyruvate kinase

L-PK

chloramphenicol acetyltransferase reporter genes

L-PK gene cap site


Input: The disturbance of pulmonary gas exchange, as revealed by the high value of AaDO2, existed without left ventricular dysfunction, and AaDO2 had no significant relationship with any of the hemodynamic parameters including the difference between plasma colloid osmotic pressure and PCW.


Input: A dose of 3 and 6 micrograms/kg/day GM-CSF reduces the severity of neutropenia and thrombocytopenia after carboplatin-cyclophosphamide chemotherapy, which may lead to more effective chemotherapy for ovarian cancer in the future.

GM-CSF


Input: These differences involve specific hydrogen-bonding interactions between the protein and DNA, including guanine N7 sites in the major groove of DNA, and alterations in DNA phosphodiester conformation induced by protein binding.


Input: Biochemical analysis demonstrates that the BJ1 protein is associated with nucleosomes and is released from chromatin by agents which intercalate into DNA, as previously shown for the high mobility group proteins (HMGs).

BJ1 protein

high mobility group proteins

HMGs


Input: I propose that their gene products bind to the chromatin to establish or maintain a proper higher order structure as a prerequisite for a regulated gene expression.


Input: The C4BP alpha gene is organized as follows: the first exon codes for the first 198 nucleotides of the 5' UTR.

C4BP alpha gene


Input: The human immunodeficiency virus type 1 (HIV-1) Rev protein is a positive posttranscriptional regulator of viral structural gene expression and essential for virus replication.

human immunodeficiency virus type 1 (HIV-1) Rev protein


Input: The CDC7 gene has two in-frame AUG codons as possible translation start sites, which would produce 58-and 56-kDa proteins, respectively.

CDC7 gene


Input: Differences in the clinical presentation and the gross appearance of the two cases are described, and similarities in the microscopic features are discussed.


Input: MEASUREMENTS AND MAIN RESULTS: The two groups were similar on entry into the study, including mean FEV1 measurements (0. 70 L atropine/0. 60 L metaproterenol, P greater than. 05).


Input: Using an ELISA, we found that surfactant protein A (SP-A) was markedly elevated in the pneumonia patients.

surfactant protein A

SP-A


Input: In view of the short t1/2, we used three doses/day.


Input: Temporal control of GUS expression was found to involve two negative regulatory sequences, NRS1 (-391 to-295) and NRS2 (-518 to-418), as well as the positive domain UAS1.

GUS


Input: We purified a Ca2 +/calmodulin (CaM)-dependent protein kinase (CaM kinase) from the yeast Saccharomyces cerevisiae with properties similar to mammalian type II CaM kinases.

Ca2 +/calmodulin (CaM)-dependent protein kinase

CaM kinase

mammalian type II CaM kinases


Input: In most cases, DR4-homozygous, DRB1-heterozygous individuals could be genotyped with the panel of probes.


Input: The prevalence of opportunistic infection among surviving AIDS patients and the probability of being in tumour response following cancer therapy conditional on being alive are two examples of such functions.


Input: Genomic clones encompassing the human ETS1 gene were isolated and utilized to define its molecular organization.

human ETS1 gene


Input: Polymerase chain reaction analysis of ETS1 cDNA identified several amplified products, indicating alternative splicing.

ETS1 cDNA


Input: Most of the expressed human E3 polypeptides (five bands) were found in the insoluble pellet while primarily full-length mature E3 was found in the soluble fraction.

human E3 polypeptides

full-length mature E3


Input: To test promotor function, chimeric genes were constructed linking fragments of chicken IGF-I 5'-flanking DNA to a promoterless reporter plasmid.

IGF-I


Input: The alpha 4 gene 5' flanking region acted as a promoter in transfection assays.

alpha 4 gene


Input: Characterization of the alpha 4 integrin gene promoter.

alpha 4 integrin gene promoter


Input: Only the 3. 0-kb transcript was detected in adult tissues, where its expression was restricted almost exclusively to the central nervous system.


Input: Two homologues of the rhombotin gene have now been isolated.

rhombotin gene


Input: Angina haemorrhagica bullosa causing respiratory obstruction postoperatively.


Input: We examined the effects of long-term perfusion with pyridoxalated hemoglobin polyoxyethylene conjugate (PHP) solution on cardiac function of isolated rat hearts.

hemoglobin


Input: The gcd2-503 mutation also results in polysome runoff, accumulation of inactive 80S ribosomal couples, and accumulation of at least one of the subunits of the general translation initiation factor 2 (eIF-2 alpha) in 43S-48S particles following a shift to the restrictive temperature.

80S ribosomal couples

general translation initiation factor 2

eIF-2 alpha


Input: Eight patients with ARC and renal failure were recently evaluated.


Input: To measure the enhancer activity of DR60, a reporter plasmid was constructed that contained DR60 cloned upstream of the reporter chloramphenicol acetyltransferase gene under the control of the delayed-early 39K promoter.

chloramphenicol acetyltransferase gene


Input: A single case of an adenocarcinoma, arising in a retroperitoneal enterogenous cyst and which presented as a left renal cyst, is reported.


Input: Using the polymerase chain reaction, we analyzed the U6 RNA genes of 52 organisms.

U6 RNA genes


Input: Both tear volume and tear flow were found to be significantly (P less than 0. 001) decreased up to 6 h after instillation, reaching a minimum 90 min after application (tear volume:-63%; tear flow:-71%).


Input: Hydrophobicity analysis indicated that the KlaA and KlaB polypeptides are likely to be soluble, whereas the KlaC polypeptide was predicted to have four potential membrane-spanning domains.

KlaA

KlaB polypeptides

KlaC polypeptide


Input: To facilitate the availability of important new therapeutic agents, the Food and Drug Administration (FDA) in the mid-1970s began assigning therapeutic ratings to investigational new drugs and holding end-of-phase II conferences with drug sponsors.


Input: In contrast, similar rates of B. sphaericus products, ABG-6184 technical powder and BSP-2 flowable concentrate, produced no significant reduction.


Input: Furthermore, the DNA polymerase II complex was difficult to obtain from dpb2-1 mutant cells, suggesting that a stable DNA polymerase II complex requires DPB2 and is essential for chromosomal replication.

DNA polymerase II complex

DNA polymerase II complex


Input: To determine whether mononuclear cell secretory products contribute to the changes in bone turnover that characterize the development of postmenopausal osteoporosis, we evaluated the effects of oophorectomy and subsequent estrogen replacement on the spontaneous secretion of interleukin 1 (IL-1) and tumor necrosis factor alpha (TNF-alpha) and on the phytohemagglutinin A-induced secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) from peripheral blood mononuclear cells.

interleukin 1

tumor necrosis factor alpha

TNF-alpha

phytohemagglutinin A

granulocyte-macrophage colony-stimulating factor

GM-CSF


Input: There were 45 to 56 nt differences between the virulent and avirulent groups while there were 6 to 14 nt differences among four avirulent strains.


Input: The standard principles of surgical management must be adhered to when using Sandostatin to treat patients with these disorders.


Input: Some of the PCR products contained mutations in ATG1 and/or ATG2.


Input: These data suggest that the levels of oxygen free radicals were increased in hepatocytes and mitochondria.


Input: The sequence of the pMxL1 plasmid containing the invertible region contains a perfect tandem repeat of 19 bp in the orientation 1 nonexpressed pilin gene at the middle of the recombination junction site.

pilin gene


Input: No evidence for the presence of introns within the acvA gene has been found.

acvA gene


Input: These observations, together with the occurrence of putative 4'-phosphopantetheine-attachment sites and a putative thioesterase site, are discussed with reference to the reaction sequence leading to production of the ACV tripeptide.

thioesterase site

ACV tripeptide


Input: Pargyline, a monoamine oxidase inhibitor, reduces peak 3 transiently (max.

monoamine oxidase


Input: When given the choice between an estrous female and a sexually active male in the AOF, flutamide females, as well as controls, preferred the male partner.


Input: Hypoxic ventilatory responses were-1. 99 +/-0. 37 L/min/% SaO2 in the relatives and-1. 54 +/-0. 25 L/min/% SaO2 in the control subjects. (ABSTRACT TRUNCATED AT 250 WORDS)


Input: Very small deletions within the conserved region completely abolished transforming activity of dbl, while extensive deletion outside of this region had no effect.

dbl


Input: This computerized list was linked to the central files of the Massachusetts Cancer Registry and cases diagnosed between 1982 and 1988 were identified.


Input: We also present evidence for a negative regulatory element in the 5' flanking region of the Mlu I upstream activation sequence.

Mlu I upstream activation sequence


Input: Mechanism of activation of the vav protooncogene. vav is a human locus that appears to be specifically expressed in cells of hematopoietic origin regardless of their differentiation lineage.

vav protooncogene

vav


Input: Endothelial cell seeding.


Input: Menetrier disease in a child.


Input: After hemodynamic stabilization, the goal of therapy is to diminish the chance that an ulcer will continue to bleed or will rebleed.


Input: Thirty seven patients (amitriptyline n = 16, moclobemide n = 21) completed the six week protocol, which was conducted under double blind conditions.


Input: The stimulus threshold for EER showed a less individual variation than amplitude.


Input: Analysis of electrically evoked response (EER) in relation to the central visual pathway of the cat (1).


Input: Furthermore, plasma fibrinogen levels increased by a mean of 17. 6%, a potentially adverse effect of gemfibrozil that has not been previously reported.

fibrinogen


Input: Gemfibrozil in hyperlipidaemic patients with peripheral arterial disease: some undiscovered actions.


Input: An RME1-independent pathway for sporulation control in Saccharomyces cerevisiae acts through IME1 transcript accumulation.

IME1 transcript


Input: The role of pharmacological profiling in safety assessment.


Input: Its application in Madagascar: advantages and disadvantages


Input: The authors evaluate the clinical efficacy of EMB AZS in recurrent ulcer after operation on the stomach caused by a high level of acid production and ulcerative gastroduodenal bleeding.


Input: To investigate the regulation of Spec gene activity, the region around the Spec1 transcriptional initiation site was analyzed for sites of protein-DNA interaction.

Spec gene

Spec1 transcriptional initiation site


Input: Phosphopeptide mapping revealed the same autophosphorylation sites utilized by EGFR-IC as those identified in wild-type EGFR.

EGFR-IC

wild-type EGFR


Input: The encoded sequence revealed a typical signal peptide, a predominantly hydrophilic 707 amino acid residue domain with 8 N-glycosylation sites, a transmembrane domain, and a C-terminal domain of 52 amino acids.


Input: The TCF-1 alpha binding site was also required for TCR alpha enhancer activity in transcriptionally active extracts from Jurkat but not HeLa cells, confirming that TCF-1 alpha is a T-cell-specific transcription factor.

TCF-1 alpha binding site

TCR alpha enhancer

TCF-1 alpha

T-cell-specific transcription factor


Input: A new semi-automatic method for quantifying regional cerebral uptake of 99m technetium-hexamethylpropylene amine oxime (99mTc-HMPAO) was used to assess single photon emission tomograms from 5 normal subjects, 14 patients with Alzheimer' s disease, 14 patients with dementia of frontal lobe type and 4 patients with dementia with motor neurone disease.


Input: The results showed that fog, up to a level of base plus fog of 0. 6 optical density units, had no influence on the diagnostic accuracy in the absence of any compensation.


Input: IdB 1031 was first extracted by liquid-solid partition and the extracts were evaporated and analysed on a reversed-phase column under isocratic conditions, using either an electrochemical or a UV detector.


Input: In this model, eltoprazine has a very specific anti-aggressive (serenic) profile, inhibiting aggression while social interaction and exploration are not decreased but even enhanced; inactivity, a measure for sedation, is not affected.


Input: A new method for the in vitro transfer of delayed hypersensitivity by dialysed transfer factor.

transfer factor


Input: Effect of separate and combined effects of plutonium-239, hexachlorobutadiene and tributyl phosphate on the thymus gland of rats


Input: Data collection was made with a query language, and data analysis performed with an interactive knowledge-based statistical tool, MAXITAB, employing a multivariate tabular analysis technique.


Input: ARPIA has been implemented by using a relational DBMS, very cheap and highly diffused on personal computers.


Input: Diuresis was induced by scheduled drinking of tea (150 ml/h).


Input: Diagnostic value of adenosine deaminase activity in tuberculous effusions.

adenosine deaminase


Input: Femoral strain adaptation after total hip replacement: a comparison of cemented and porous ingrowth components in canines.


Input: Immuno-cytochemistry, using antisera against Campylobacter jejuni, showed that the positive staining in altered epithelial cells were restricted to intracellular organisms having a structure resembling Campylobacter spp.


Input: Promoter activities were estimated using beta-glucuronidase and neomycin phosphotransferase II reporter gene systems.

beta-glucuronidase

neomycin phosphotransferase II reporter gene systems


Input: The 5' regions of these two soybean actin genes contain many unusual features including (CT) repeats and long stretches of pyrimidine-rich DNA.

soybean actin genes


Input: All 8 (100%) patients with fulminant hepatic failure who received grafts survived, including 3 who received ABO-incompatible grafts, though 2 of these subsequently required retransplantation.


Input: No patient had a history of excess alcohol intake, or prolonged intake of hepatotoxic drugs and steroids, and were not obese or malnourished.


Input: An evolutionary comparison of amino acid sequences of 34 HSP70 proteins from 17 species suggests that BiP genes share a common ancestor, which diverged from other HSP70 genes near the time when eukaryotes first appeared.

HSP70 proteins

BiP genes

HSP70 genes


Input: Spore inocula (approximately 10 (6)/coupon) were dried onto 0. 5-in.


Input: However, overexpression of both the STE4 and STE18 proteins did not generate a stronger pheromone response than overexpression of STE4 in the presence of wild-type levels of STE18.

STE18 proteins


Input: Reverse transcription-PCR was then used to clone from human poly (A) + RNA the cDNA corresponding to the expressed homolog of psi ARF 4, referred to as human ARF 4.

psi ARF 4

human ARF 4


Input: To evaluate the cost and benefits of screening tests for Chlamydia trachomatis in adolescent males, we developed a decision analysis model and compared the leukocyte esterase urine dipstick test with culture, with direct-smear fluorescent antibody (DFA), and with the option of no screening (no treatment).

leukocyte esterase


Input: Sequencing the gene for an imipenem-cefoxitin-hydrolyzing enzyme (CfiA) from Bacteroides fragilis TAL2480 reveals strong similarity between CfiA and Bacillus cereus beta-lactamase II.

CfiA

CfiA

Bacillus cereus beta-lactamase II


Input: The cloned HindIII fragment, which was shown by DNA sequence analysis to encode the N-terminal half of the B. subtilis IF2 protein and 0. 2 kb of upstream flanking sequence, was utilized as a homologous probe to clone an overlapping 2. 76-kb ClaI chromosomal fragment containing the entire IF2 structural gene.

HindIII fragment

B. subtilis IF2 protein

2. 76-kb ClaI chromosomal fragment

entire IF2 structural gene


Input: Maternal seizures had occurred during pregnancy in 52 per cent.


Input: It encodes a protein with three zinc fingers similar to those of the transcription factor Sp1.

transcription factor Sp1


Input: Krox-24 is therefore a sequence-specific transcriptional activator.


Input: The interindividual variability of the parameters is taken into consideration by interactively determining the threshold levels.


Input: Inspired CO2 causing changes from hypo-to normocapnia has previously been shown to improve arterial O2 tension (PaO2) and to reduce alveolar-arterial O2 difference.


Input: Expression, nucleotide sequence and mutational analysis of two open reading frames in the nif gene region of Anabaena sp. strain PCC7120.

nif gene region of Anabaena sp. strain PCC7120


Input: Our results suggest that a sequence match between enhancers and certain promoter elements is critical.


Input: This Mr is similar to those of the purified smg p25A GDI estimated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and sucrose density gradient ultracentrifugation, which are about 54, 000 and 65, 000, respectively.

purified smg p25A GDI


Input: Yeast mutants assigned to the pet complementation group G104 were found to lack alpha-ketoglutarate dehydrogenase activity as a result of mutations in the dihydrolipoyl transsuccinylase (KE2) component of the complex.

pet

alpha-ketoglutarate dehydrogenase

dihydrolipoyl transsuccinylase


Input: Critical residues required for repression are located within the C-terminal 27 amino acids of c-Fos, since v-Fos and C-terminal truncations of c-Fos did not down regulate.

c-Fos

v-Fos

c-Fos


Input: We also discovered a V lambda pseudogene, called psi V lambda 1, 3 kb upstream of the U266 lambda gene.

V lambda pseudogene

psi V lambda 1

U266 lambda gene


Input: In this paper, we have analyzed the structure of human gene for Gx alpha, which spans more than 60 kilobases.

Gx alpha


Input: A long follow-up study revealed that convalescent stage children still have the potency to have an immediate type hypersensitivity reaction on exposure to mite antigen, with a high titer of mite specific IgE in their sera, but they are free from asthmatic attacks because of the reduction in the amount of mite antigen in the body, as shown by the reduction in the amount of mite specific IgG.

mite specific IgE

mite specific IgG


Input: But no influence was observed at lower concentrations than 1/4 MIC of AMK.


Input: Furthermore, we notice two potential consensus motifs which are also found in corresponding positions in the genes for the nerve growth factor receptor and the 68-kDa neurofilament protein.

nerve growth factor receptor

68-kDa neurofilament protein


Input: In addition, the-119 to-81 fragment of the CCK promoter contains a transcriptional enhancer that potentiates the transcription from the herpes simplex virus thymidine kinase promoter in a position-and orientation-independent manner.

CCK promoter

thymidine kinase promoter


Input: Thirty minutes of supine restraint decreased DOPAC concentrations in the median eminence of female rats that were not exposed to ether, and brief exposure to ether enhanced this effect.


Input: Influence of metoprolol treatment on sympatho-adrenal activation of fibrinolysis.


Input: Five of 10 scars studied decreased at least 50% in linear dimensions.


Input: Managing dysphagia in a chronic care setting: an introduction.


Input: Gel-mobility-shift assays confirmed that the Raji nuclear proteins that bound to W and V elements were competed with by an HLA-DRA X-box oligonucleotide.

HLA-DRA X-box oligonucleotide


Input: The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins.

NF1 locus

mammalian GAP

yeast IRA proteins


Input: A second isotype of Raja immunoglobulin heavy chain genes has been detected by screening a spleen cDNA library with homologous Raja VH-and CH1-specific probes complementing the respective regions of the mu-like isotype.

Raja immunoglobulin heavy chain genes

Raja VH

mu-like isotype


Input: Petko, and S.


Input: Disruption of ARF2 causes no detectable phenotype.


Input: Human recombinant DNA-derived antihemophilic factor (factor VIII) in the treatment of hemophilia A. recombinant Factor VIII Study Group.

antihemophilic factor

factor VIII

Factor VIII


Input: Like other members of this family, the AP-4 HLH motif and the adjacent basic domain are necessary and sufficient to confer site-specific DNA binding.


Input: Furthermore, expression of the promoter in embryonic Drosophila melanogaster cells that lack MyoD1 and Sp1 is strictly dependent on all three sites remaining intact and on the presence of exogenously supplied Sp1 and MyoD1.


Input: Effects of a selective monoamine oxidase (MAO)--A inhibitor, clorgyline, a selective MAO-B inhibitor, deprenyl, and a non-selective MAO inhibitor, nialamide, were investigated on footshock-induced aggression (FIA) in paired rats.

monoamine oxidase (MAO)--A

MAO-B

MAO


Input: To identify structural features of residues flanking the c-region that influence the fidelity and efficiency of signal peptidase cleavage as well as co-translational translocation, we introduced six amino acid substitutions into the COOH terminus of the hydrophobic core and seven substitutions at the NH2 terminus of the mature region (the + 1 position) of a model eukaryotic preprotein-human pre (delta pro) apoA-II.

eukaryotic preprotein-human pre (delta pro) apoA-II


Input: Additionally, although c-fos and egr-1 mRNAs are expressed at elevated levels in stimulated liver cells, fos-B, fra-1, and egr-2 are not, which suggests that factors in addition to the serum response factor participate in the regulation of immediate-early gene induction.

c-fos

egr-1 mRNAs

fos-B

serum response factor

immediate-early gene


Input: Of 848 patients, 819 cases with complete description of patient' s background were evaluable: Group A (surgery + MMC + 5-FU: chemotherapy) 253 cases, group B (surgery + MMC + 5-FU + OK-432 or PSK: immunochemotherapy) 282 and group C (surgery alone) 284.


Input: The nuclear proteins encoded by the c-fos and c-jun protooncogenes are expressed during the proliferation period of osteoblast phenotype development.

c-fos

c-jun protooncogenes


Input: This model is further supported by binding of the Fos-Jun complex at an AP-1 site in the type alpha I collagen promoter that is contiguous with, but not overlapping, the VDRE.

Fos

Jun

AP-1 site

type alpha I collagen promoter


Input: PBSX is induced by agents which elicit the SOS response.

PBSX


Input: A bacteriological relapse requiring treatment occurred by 5 years in 16. 8% of 113 R3, 5. 2% of 97 R5, and 20. 0% of 115 Z5 patients with organisms sensitive to streptomycin and isoniazid initially.


Input: In the controls, it was found that all right-handed and 10 out of 14 left-handed control subjects showed a right VHF (i. e., left hemisphere) advantage.


Input: Although no Rh-antibodies were demonstrable, a similar mechanism can be postulated for the Rh-system.

Rh-antibodies


Input: This study was performed to clarify the location of a transesophageal echocardiographic (TEE) transducer when obtaining the short-axis view of the left ventricle (S-LV).


Input: From S3 (CBF: 79-60%) to S5 (CBF: 39-0%),% WTh, 1/TPC and 1/T were significantly decreased from those of the control levels (all p less than 0. 01).


Input: In that case, the ratio of brush abrasion was 0. 268, compressive and transverse strength, 124. 3 and 86. 3 MPa respectively, hardness, 43. 2 Hk, water absorption 14. 2 micrograms/mm3 and thermal expansion coefficient, 47. 4 x 10 (-6)/degrees C.


Input: 9, 1498-1506).


Input: In a highly select group of stable hypertensive patients, we have assessed the strength of association between various blood pressure measurements (24 h average automated ambulatory blood pressure, 4 h automated ambulatory morning average blood pressure, multiple office visit average blood pressure, and a single office visit average blood pressure) and various echocardiographic indices of hypertensive cardiac target organ damage (left atrial diameter, left ventricular end diastolic diameter, posterior wall thickness, combined wall thickness, relative wall thickness, left ventricular mass and mass index, and combined wall thickness/left ventricular diastolic diameter ratio).


Input: The p36 gene is at least 22 kb in length and has a coding sequence of approximately 1 kb, representing only 4. 5% of the gene. (ABSTRACT TRUNCATED AT 250 WORDS)

p36 gene


Input: This multimodality treatment for locally advanced gynecologic tumors appears feasible with modification, and continued work exploring this approach is encouraged.


Input: With the modified fingertip-to-floor (MFTF) method, patients stand on a stool and forward bend so that measurements can be taken on patients who are able to touch the floor or reach beyond the level of the floor.


Input: No significant differences could be seen in response rates according to the concentration of estrogen receptors or presence of progesteron receptors in this group of patients.

estrogen receptors

progesteron receptors


Input: Teicoplanin was given most often because of persistent fever or initial Gram-positive bacteraemia and only one-third of these cases responded.


Input: In Experiments 1 and 2, infants, like adults, initially categorized novel objects on the basis of physical appearance, but only if trained with multiple exemplars, after delays of 1 and 7 days.


Input: The clinical picture of the disease was significantly different from anthropogenic cutaneous leishmaniasis caused by L. tropica but similar to cutaneous patterns caused by L. infantum which was a prevalent pattern in the southern France.


Input: In comparison with the 16 introns reported in AHA3, AHA2 is missing one intron in the 5'-untranslated region and a second intron in the C-terminal coding region.


Input: Northern blot analysis indicates that AHA2 mRNA relative to total cellular RNA is expressed at significantly higher levels in root tissue as compared with shoot tissue.

AHA2 mRNA


Input: Impaction of gastrostomy tube in the abdominal wall.


Input: Both antidepressants elevated the pain threshold acutely, while pretreatment with pCPA largely blocked the analgesia.


Input: Sci.


Input: A needs assessment of these families was also done.


Input: TCR alpha and beta gene expression may be regulated by a common set of T-cell nuclear proteins in that the T beta 2 element binding a set of cyclic AMP response element-binding proteins that are also bound by the T alpha 1 element of the human TCR alpha enhancer and the decamer element present in a large number of human and murine TCR beta promoters.

TCR alpha and beta gene

T-cell nuclear proteins

T beta 2 element

cyclic AMP response element-binding proteins

T alpha 1 element

TCR alpha

TCR beta


Input: The 3' stem-loop is highly divergent in structure among species and lies immediately upstream of the binding site for Sm proteins.

Sm proteins


Input: The deleted nucleotide sequence corresponded to sequences that, by analogy to the organization of the type I collagen genes, should be precisely encoded by exon 41 of the COL3A1 gene.

type I collagen genes

COL3A1 gene


Input: These losses account for the resistance of EDS-IV collagen to cyanogen bromide and mammalian collagenase digestion.

collagen

mammalian collagenase


Input: Two other peptides, either partially or totally lacking the basic region, but containing the intact leucine zipper domain, readily form dimers but do not bind to the CRE.


Input: In contrast, the CRE of the human c-fos promoter located at-60 was weakly induced by cAMP and E1a in both HeLa and PC12 cells.

human c-fos promoter


Input: We have isolated and sequenced the gene encoding the human U1-70K snRNP protein.

human U1-70K snRNP protein


Input: Although popular this hypothesis is far from explaining all the clinical facts, namely that rigidity is equal in extensor and flexor, proximal and distal muscles.


Input: Fluid (AVLF) 31.


Input: The results supported the therapeutic principle of TCM: Treating patients according to their pathophysiological patterns.


Input: The nmr gene is the major negative regulatory gene in the nitrogen control circuit of Neurospora crassa, which, together with positive regulatory genes, governs the expression of multiple unlinked structural genes of the circuit.

nmr gene


Input: The 4 days dexamethasone suppression test showed more than 80% suppression of dehydroepiandrosterone-sulphate and a variable (40-60%) reduction of testosterone and androstenedione levels.


Input: The ratio of P-31 NMR-S derived inorganic phosphates [Pi] to phosphocreatine [PCr] was significantly greater at rest in LVH baboons [0. 53 +/-0. 06 versus controls = 0. 41 +/-0. 17; P less than 0. 05].


Input: Cutaneous necrosis associated with protein S deficiency.

protein S


Input: Critical study


Input: Regional cerebral blood flow was measured using N-isopropyl-123I-iodoamphetamine with single-photon emission computed tomography (CT) in 16 aged patients with noninsulin-dependent diabetes mellitus (NIDDM, average age 72. 8 years, average fasting plasma glucose 7. 7 mmol/L), and 12 nondiabetic subjects (71. 6 years, 5. 3 mmol/L).


Input: Mean ROI-A/B ratio was 49. 6 +/-1. 7% in the diabetic group, significantly lower than the 57. 9 +/-1. 6% at the nondiabetic group (p less than 0. 005).


Input: These data strongly implicate the normal product of the int-2 gene, which is related to the fibroblast growth factor family, as a contributory factor in virally induced mammary tumors.

int-2 gene

fibroblast growth factor family


Input: The PC2 protein also shows great similarity to the incomplete NH2-terminal sequence of the human furin gene product, a putative membrane-inserted receptor-like molecule.

PC2 protein

human furin gene product


Input: Whether or not there are sequences conferring cAMP responsiveness which are common both to P-450scc and the other steroidogenic P-450 genes remains to be established.

P-450 genes


Input: In this study, we used footprinting and gel mobility retardation assays to reveal that bacterially synthesized Zta fusion proteins bound directly to six TGTGCAA-like motifs within DSL.

Zta fusion proteins

DSL


Input: The zta transactivator involved in induction of lytic cycle gene expression in Epstein-Barr virus-infected lymphocytes binds to both AP-1 and ZRE sites in target promoter and enhancer regions.

zta transactivator

ZRE sites


Input: It is the human homolog of the mouse Mx protein involved in resistance to influenza virus.

mouse Mx protein


Input: Fragments containing the 21-base-pair repeat region, the enhancer of simian virus 40 or both strongly stimulated beta-galactosidase synthesis, and three fragments from the polyomavirus enhancer region stimulated moderate levels.

enhancer of simian virus 40

beta-galactosidase

polyomavirus enhancer region


Input: The sites targeted for mutagenesis, residues 60, 61, and 66, are located within a putative helical loop structure which may be involved in substrate recognition by the enzyme.


Input: The possible benefits of LMW heparin (reduced frequency of bleeding, alleviation of hypertriglyceridemia) were not, however, apparent, possibly because of the short observation period and the low incidence of hemorrhagic complications in routine dialyses.


Input: The deduced amino acid sequence of destrin is 165 residues long and is very similar (71% identical) to that of cofilin, a widely distributed, pH-sensitive actin-modulating protein.

destrin

cofilin

actin


Input: Summers, Virology 89: 517-527, 1978).


Input: With only purified T antigen in the presence of topoisomerase I to unwind purified DNA, ori-auxiliary sequences strongly facilitated T-antigen-dependent DNA conformational changes consistent with melting the first 50 base pairs.

T antigen

topoisomerase I

T-antigen


Input: A rabbit antiserum was raised against a synthetic peptide corresponding to a hydrophilic portion of the translated murine cDNA sequence.


Input: Conservation of function of Drosophila melanogaster abl and murine v-abl proteins in transformation of mammalian cells.

Drosophila melanogaster abl

murine v-abl proteins


Input: Specific binding of the protein factors to the sites, possibly to the three Mt sequences, may play an important role in the coordinate regulation of the transcription of nuclear genes encoding subunits responsible for mitochondrial oxidative phosphorylation.


Input: This points to a specific interference with HSV-induced DNA amplification.


Input: Constructs were made in which an AATAAA and the GT-rich region were separated by various distances ranging from 7 to 43 bp.


Input: To address this issue, the gene for factor Y has been cloned molecularly and its DNA sequence has been determined.

factor Y


Input: We cloned and sequenced the cDNAs against genomic RNA and mRNA for phosphoprotein (P) of human parainfluenza type 2 virus (PIV-2). cDNA clone from genomic RNA was 1439 nucleotides in length excluding poly (A) and was found to have two small open reading frames encoding proteins of 233 and 249 amino acids.

phosphoprotein (P)


Input: We show that cytR expression is negatively controlled by the CytR protein and positively affected by the cAMP/CAP complex.

cytR

CytR protein

cAMP/CAP complex


Input: The cDNA sequence has an 813-bp open reading frame (ORF) whose predicted amino acid sequence is 97. 6% identical to the 272 carboxy-terminal amino acids of the human ets-1 protein.

human ets-1 protein


Input: To characterize the O7-LPS region, the recombinant cosmids pJHCV31 and pJHCV32 were mutagenized by transposon mutagenesis with Tn3HoHo1, which carries a promoterless lac operon and can therefore generate lacZ transcriptional fusions with target DNA sequences.

O7-LPS region

lac operon

lacZ


Input: The sacT gene regulating the sacPA operon in Bacillus subtilis shares strong homology with transcriptional antiterminators.

sacT gene

sacPA operon in Bacillus subtilis


Input: Various mutant HN genes were constructed to examine the role of residues flanking the signal-anchor domain, including the cytoplasmic tail, on assembly and intracellular transport of the HN glycoprotein.

mutant HN genes

HN glycoprotein


Input: Our studies extend these findings and show that the E2 transactivation gene is expressed from multiple promoters.

E2 transactivation gene


Input: Furthermore, analysis of the E2 proteins present in various cell lines harboring specific BPV-1 mutants, including the 2558 acceptor mutant, proves that alternate modes of E2 expression exist.

E2 proteins


Input: Disruption of the IRA2 gene resulted in (i) increased sensitivity to heat shock and nitrogen starvation, (ii) sporulation defects, and (iii) suppression of the lethality of the cdc25 mutant.

IRA2 gene

cdc25 mutant


Input: This cohort of patients was selected on the basis of clinical stage.


Input: The diagnosis of miliary tuberculosis should be systematically considered in ARDS of unknown origin.


Input: In order to characterize the functional elements of the promoter that in some way must respond to these regulatory signals, a number of promoter mutations were constructed, including a set of linker-scanning mutations across the entire promoter region.


Input: A DNA motif related to the cAMP-responsive element and an exon-located activator protein-2 binding site in the human tissue-type plasminogen activator gene promoter cooperate in basal expression and convey activation by phorbol ester and cAMP.

exon-located activator protein-2 binding site

human tissue-type plasminogen activator gene promoter


Input: The 26S rRNA binding ribosomal protein equivalent to bacterial protein L11 is encoded by unspliced duplicated genes in Saccharomyces cerevisiae.

26S rRNA binding ribosomal protein

bacterial protein L11


Input: Five healthy male subjects inspired air for 20 min and then 5% CO2/95% O2 for 30 min, of which the first 10 min was used to achieve a steady-state end-tidal CO2 measurement.


Input: The transcripts were equally active with or without a 5' methylated capstructure as expected, since EMCV-RNA is one of the mRNAs capable of internal initiation.


Input: The E6/E7 promoter of all genital human papillomaviruses is responsible for expression of the viral transforming genes.


Input: A case of Goodpasture' s syndrome.


Input: Seventy-two of 73 negative controls and all positive blocks as seen on soft tissue radiographs (STRs) were correctly coded (specificity 98. 6%, sensitivity 100%).


Input: No symptomatic abnormality has been noted in the neonatal period except periventricular calcifications.


Input: Immunohistochemical analysis of several rat organs also showed staining in epithelial cells.


Input: Transcription of the first operon coding for m-xylene-degrading enzymes on the TOL plasmid of Pseudomonas putida is activated by the xylR gene product in the presence of m-xylene.

xylR gene product


Input: Some of the mutations obtained do not contain a copy of the Ulysses element at the mutant locus, suggesting that a different transposable element may be responsible for the mutation.

Ulysses element


Input: Determination of diquat in biological materials by electron spin resonance spectroscopy.


Input: We show also that RA represses the transcriptional activity of a reporter gene containing a TPA responding AP1 binding site driving the HSV tk promoter.

AP1 binding site

HSV tk promoter


Input: Moreover, radiolabeled EFI, NF-Y, or CBF DNAs give rise to identical gel retardation patterns in extracts from a variety of different cell types.

EFI

NF-Y

CBF DNAs


Input: Risk factors influencing lymph nodes metastasis in lung cancer with stage I, II or IIIA


Input: Multifunctional protein kinase (MFPK) phosphorylates ATP-citrate lyase on peptide B on two sites, BT and BS, on threonine and serine, respectively, inhibitor 2 on a threonyl residue, and glycogen synthase at sites 2 and 3.

Multifunctional protein kinase

MFPK

ATP-citrate lyase

peptide B

inhibitor 2

glycogen synthase


Input: The electrically induced motile responses were not suppressed in the presence of dinitrophenol or cytochalasin B.


Input: Unlike p59v-rel, which is a nuclear protein in CEF, indirect immunofluorescence showed that p68c-rel in JD214c-rel infected CEF is located exclusively in the cytoplasm of these cells, even though the sequence of p68c-rel showed that it contains a nuclear localizing sequence identical to the one previously identified in p59v-rel.

rel

rel

rel

rel


Input: Kinetic experiments revealed that within 10 min this radiolabeled precursor protein was converted in HL-60 cells into an Mr approximately 150, 000 chondroitin sulfate proteoglycan intermediate.


Input: Blood flow and velocity (measured using Doppler ultrasound) gradually decreased during diastole and ultimately reversed in direction as cotyledon resistance was increased up to 14 fold.


Input: A total of 112 patients received anistreplase and 119 received heparin within a mean period of 188 +/-62 min following the onset of symptoms.


Input: The promoter activity was measured by a transient expression of a chloramphenicol acetyltransferase (CAT) gene connected with various 5'-deletion mutants of the 5'-flanking region.

chloramphenicol acetyltransferase

CAT


Input: The Saccharomyces cerevisiae 14DM gene, encoding cytochrome P450 lanosterol 14 alpha-demethylase (14DM), was overexpressed in various S. cerevisiae strains under the control of three strong heterologous yeast transcription promoters (pADC1, pGPD, pPHO5) and under the control of its own promoter.

Saccharomyces cerevisiae 14DM gene

cytochrome P450 lanosterol 14 alpha-demethylase

pGPD


Input: Truncations composed of 78 and 64 amino acids were translocated across the endoplasmic reticulum membrane, and translocation was found to be strictly co-translational and SRP-dependent.

SRP


Input: Pulmonary vascular resistance was not altered, ejection fraction remained unchanged and isovolumic relaxation period was lengthened (119 +/-20. 1 to 147. 39 +/-21. 15, P less than 0. 05).


Input: The ANB1 locus of Saccharomyces cerevisiae encodes the protein synthesis initiation factor eIF-4D.

ANB1 locus

protein synthesis initiation factor eIF-4D


Input: Serum beta 2-microglobulin levels (beta-2-M) were studied in 150 drug addicts, 50 of them asymptomatic carriers of anti HIV-1 antibodies, 50 symptomatic carriers with persistent generalized lymphadenopathy (P. G. L.) and 50 serum negative patients who had been living in a closed community for at least 2 years.

Serum beta 2-microglobulin

anti HIV-1 antibodies


Input: This emancipation of the ability to copulate from hormonal influence makes female sexual motivation the primary regulator of mating in primates.


Input: No therapy exists for halting the progression of the disease with the possible exception of laser photocoagulation treatment used to ablate subretinal neovascular membranes in an attempt to avoid complications of subretinal hemorrhages.


Input: R.


Input: Specific hyperimmune globulins to pathogens such as Haemophilus influenzae and Streptococcus pneumoniae have also been studied.

hyperimmune globulins


Input: Therapeutic effects of cefpirome (HR 810) on experimental mixed infections with Enterococcus faecalis and Escherichia coli in mice.


Input: Regulation of yeast LEU2.

yeast LEU2


Input: Homozygous individuals usually develop purpura fulminans as newborns; heterozygous protein C-deficient individuals are at increased risk for venous thrombosis and pulmonary embolism.

protein C


Input: Ischemic stroke due to protein C deficiency.

protein C


Input: TREB7 and TREB36 protected all three repeats of the 21 bp, but TREB5 protected only the second repeat.


Input: These results suggest that 5 KE X 3/W may be the optimal regimen to augment the antitumor immunity of RNL.


Input: Analysis of various deletion mutants indicates that the sequence requirements for binding by QBP in vitro are indistinguishable from those necessary for Q activity in vivo, strongly suggesting that QBP is required for the function of this TATA-independent promoter.

QBP

QBP


Input: Since general regulatory factor I (GRFI)/repressor/activator site binding protein 1 (RAP1)/translation upstream factor (TUF) is believed to be an activator of MAT alpha expression, we examined whether PYK1, which is known to be regulated by GRFI/RAP1/TUF, is also affected by the gal11 mutation.

general regulatory factor I

GRFI

repressor/activator site binding protein 1

translation upstream factor

TUF

MAT alpha

GRFI

TUF

gal11 mutation


Input: Yeast Gal11 protein mediates the transcriptional activation signal of two different transacting factors, Gal4 and general regulatory factor I/repressor/activator site binding protein 1/translation upstream factor.

Yeast Gal11 protein

general regulatory factor I

repressor/activator site binding protein 1

translation upstream factor


Input: Deletion from either the N-or C-terminal ends of repA (28 and 69 codons, respectively, out of the 286-codon open reading frame) affected the initiator but not the inhibitory activity.

repA


Input: The two larger peptides, one containing amino acids 1-228 and the other containing amino acids 85-228, formed dimers in solution and bound DNA specifically as a dimer.


Input: In vitro transcription extracts from ret1-1 cells terminate less efficiently at weak transcription termination signals than those from RET1 cells, using a variety of tRNA templates.


Input: Guiding patients in the decision should involve a multidisciplinary team composed of a surgical oncologist, geneticist, pathologist, psychotherapist and plastic surgeon.


Input: These factors belong to a set of genetically distinct molecules, including AP-4 and MLTF, that bind to the CACCTGTC motif or related sequences.

MLTF