Input: The nature of the process formed by the successive occurrences of this arrhythmia was studied in 8 patients with a history of symptomatic paroxysmal AF.


Input: This would have had the effect of positioning the genes currently on the long arm adjacent to the centromeric heterochromatin, perhaps resulting in a " position effect " on transcription of these genes.


Input: Initial experience with a microprocessor controlled current based defibrillator.


Input: Obesity was strongly associated with the proportions of nonprotein-bound and albumin-bound estradiol, and inversely associated with sex hormone binding globulin (SHBG) levels and the proportion of SHBG-bound estradiol.

albumin

sex hormone binding globulin

SHBG

SHBG


Input: Heterogeneous nuclear ribonucleoprotein (hnRNP) core protein A1 is a major component of mammalian hnRNP 40 S particles.

Heterogeneous nuclear ribonucleoprotein (hnRNP) core protein A1

mammalian hnRNP 40 S particles


Input: Brain cholinesterase activity of nestling great egrets, snowy egrets and black-crowned night-herons. inhibition of brain cholinesterase (ChE) activity in birds is often used to diagnose exposure or death from organophosphorus or carbamate pesticides.

Brain cholinesterase

brain cholinesterase

ChE


Input: The effect of zinc deficiency on trace metals in the liver, spleen, kidney, pancreas and duodenum was investigated in the control and zinc-deficient rats at 17 days and 20 days of pregnancy.


Input: Our findings support the view of a multifactorial genesis of the cardiac involvement in uremic patients.


Input: Heating cells to 43 degrees C decreased the amount of newly synthesized rRNA to less than 5% of the control level and led to greater than 95% inhibition of transcription termination at a region 355 to 362 nucleotides downstream of the 3' end of 28S rRNA, with readthrough continuing into the next transcription unit.

28S rRNA


Input: Deletion analysis showed that the NF-4FA, NF-4FB, and AP-1 sequences are each necessary for full enhancer activity.


Input: Cord swelling was observed in 2 patients who developed complete lesions.


Input: Reye' s syndrome: reports of 7 cases in the period 1982-1987


Input: PULSE is used to set such NMR spectroscopic parameters as the delay and duration of rf transmit and receive gates, rf phase, sampling times, and such imaging parameters as rf pulse shape and gradient waveforms.


Input: Definite JPsA (24 patients) was defined as arthritis associated, but not necessarily coincident, with a typical psoriatic rash, or arthritis plus at least 3 of 4 minor criteria: dactylitis, nail pitting, psoriasis-like rash, or family history of psoriasis.


Input: Hence follows Kurti' s demand to mete out appropriate importance to the arguments.


Input: The author gives an account of antipsychotic, analgetic, myorelaxing and vasodilatating effects of some calcium antagonists, and their clinical application is discussed.


Input: A correlation coefficient was used for assessing the similarity of each map pattern with the normal mean IQRST map.


Input: A hospital-based study of the relationship between retained placenta and mastitis in dairy cows.


Input: This indicates that lipid peroxidation may be involved in the development of senile cataract and, as a direct consequence of retinal damage, also in the pathogenesis of cataract in diabetes and in severe myopia.


Input: The histological grading was certified in 68 cases: 12 G1, 39 G2, 17 G3; extracapsular spread was found in 20/54 cases (37%).


Input: Asthma was significantly more often associated with ASA group (91%) vs 46% at AT and in only 16% at INTR group.


Input: A value of 1. 1 l/kg was used for V in calculating all single sample estimates of clearance (CL), and a value of 4. 3 l/kg was used to calculate single sample estimates of clearance of plasma unbound drug (CLunb).


Input: The solitary kidney: a model of chronic hyperfiltration in humans.


Input: Halothane is metabolized by an oxidative pathway to stable, nonvolatile end products, trifluoroacetic acid (TFAA) and bromide (Br-), and by reductive pathways to Br-and inorganic fluoride (F-).


Input: The values were consistently lower (P less than 0. 01) during summer (3. 79 +/-0. 13 micrograms/100 ml), as compared to winter (5. 06 +/-0. 27).


Input: These results suggest that HAPE-S-S are prone to irregular nocturnal breathing patterns at high altitude, which is associated with the development of AMS, but it was not possible to determine whether these abnormal breathing patterns are a cause or an effect of AMS.


Input: It was possible to classify the animals into high and low responders according to the pattern of humoral immune response.


Input: Heart rate (HR), rectal temperature (Tre), blood pressure, temperature and relative humidity changes inside clothing were measured on 18 professional firemen (mean age 29. 4 +/-7. 4 yr, VO2 max 41. 4 + 8. 8 ml kg-1 min-1) wearing fire fighter' s uniforms (SU) or aluminized, fire resistant, impermeable clothing with self contained breathing apparatus (FE).


Input: The clinical tolerance and pharmacokinetics of FCE 22101 (sodium (5R, 6S)-6-[(1R)-hydroxyethyl]-2-carbamoyloxymethyl-2-penem-3-carboxylate), a new penem antibiotic, have been studied after giving a single i. v. dose of 4 mg. kg-1 to ten healthy male volunteers.


Input: DNA blot hybridization suggests that the rat genome may contain more than one gene encoding PtdIns transfer protein.

PtdIns transfer protein


Input: Another segment of CRL3 (-296 to-184), also displaying enhancer function, contained tandem repeated sequences (DR-A1 and DR-A2).


Input: 1-(1-Naphthyl) piperazine (1-NP) has been reported to have serotonin antagonist properties at the 5-HT2 subtype of receptor, and it has been suggested that it may have agonist actions at the 5-HT1 site.

5-HT2 subtype

5-HT1 site


Input: 1-(m-Chlorophenyl) piperazine (mCPP, 0. 1-3. 0 mg/kg) and 1-(m-trifluoromethylphenyl) piperazine (TFMPP, 0. 1-3. 0 mg/kg), both thought to act primarily at 5-HT1 sites, also decreased responding and this effect was blocked by methysergide and by 1-NP, but not by ketanserin.

5-HT1 sites


Input: The characteristic feature of liver and spleen MP function in patients with VHA associated with HBsAg carriership consisted in the lack of the compensatory reaction on the part of spleen MP, which was likely to be connected with overstrain of long standing and depletion of the MP system due to permanent antigenic stimulation of HBsAg.

HBsAg

HBsAg


Input: Changes in xanthine oxidase activity in patients with circulatory failure

xanthine oxidase


Input: A soap and water (1: 1, v/v) solution effectively decontaminated powdered stratum corneum.


Input: The cytoprotective and antiulcer activities of the antacid magaldrate (ES Riopan) as well as its effects on gastric mucosal blood flow and mucus secretions, were determined in the rat.


Input: The human immunodeficiency virus type 1 (HIV-1) preferentially infects CD4 + T lymphocytes and may exist as a latent provirus within these cells for extended periods.

CD4 +


Input: Histiocytic panniculitis was observed in biopsy specimens with cytophagocytosis.


Input: We have utilized the human 4F2 heavy chain (4F2HC) gene as a model system in studies designed to elucidate the molecular events involved in regulating inducible gene expression during normal human T-cell activation.

human 4F2 heavy chain


Input: A cDNA encoding the NF-4FB enhancer binding protein has been cloned by screening a lambda gt11 cDNA library with a rabiolabelled oligonucleotide corresponding to the NF-4FB recognition sequence.

NF-4FB enhancer binding protein

NF-4FB recognition sequence


Input: Electrocardiographic right ventricular hypertrophy was seen in 4, and biventricular hypertrophy in 5 patients.


Input: Sequencing analysis revealed that the 0. 54-and 0. 4-kb fragments are identical except for 150 nucleotides missing at the 5' region of the 0. 4-kb fragment.


Input: The mature protein also contains a cysteine-rich, highly hydrophilic region homologous to the ovomucoid serine protease inhibitors (residues 76-132).

ovomucoid serine protease inhibitors


Input: Oligosynaptic EPSP components were consistently modulated only in the superficial peroneal responses in flexor motoneurons, which exhibited enhanced amplitude during the flexion phase.


Input: Experiments on 23 white rats and 10 guinea pigs have shown that preliminarily indomethacin-induced inhibition of prostaglandins synthesis prevented development of pulmonary oedema, evoked by heterologous serum in rats and by vagotomy in guinea pigs.


Input: On the other hand, lack of conservation of the membrane attachment sequence arginine-glycine-aspartic acid argues against its functional importance in CgA.

CgA


Input: Third-and later-parity cows were randomly assigned after each parturition to Charolais and Red Poll bulls in multiple-sire pastures.


Input: Within each lobe, the PA dispersion was up to 10 cmH2O at CFV of 90 l/min; when flow decreased, PA at all sites decreased, as did the intralobar dispersion.


Input: The system consisted of the intact canine heart connected to a microcomputer that operated as the modulated parasystolic pacemaker.


Input: In order to identify and classify the basic CT appearances of interstitial pneumonia, radiologic-pathologic correlative study was performed using inflated and fixed lungs from autopsy and surgery.


Input: The disease ran an atypical course; with early jaundice syndrome, severe enterorrhagia and late appearance of roseola.


Input: The transcription factor Sp1 bound to eight sites, as demonstrated by footprinting assays and gel shift analysis with purified Sp1.


Input: The combination PIP 64 micrograms-PEF 4 micrograms prevents the frequent secondary regrowth seen after 6 hours with the antibiotics used alone.


Input: With a sample of mothers of healthy infants, all three subscales of the revised instrument, WPL-R, had acceptable levels of internal consistency at 7, 30, and 90 days postpartum, and stability across administrations.


Input: Since 1948, the use of saline-washed red cells (WRBCs) has been advocated to minimize hemolysis after transfusion to patients with PNH.


Input: In the group of asthmatics statistically significant correlation was found between PC20 PGF2 alpha and histamine values (r = 0. 538, p less than 0. 05).


Input: Acute experiments on nembutal-anesthetized cats (50 mg/kg) were employed to investigate the effect of 1 T pulsating magnetic field (PMF) on neuromuscular system of the leg.


Input: No significant differences were found between the TS and the PTS.


Input: The percentages of formed cysts and growth rates were monthly estimated and analyzed rhythmometrically by cosinor for 5 clonal cultures of Scripsiella trochoidea Stein grown for 2 years under laboratory conditions, rended as constant as possible from the view point of environmental temperature (24 +/-1 degree C), lighting (25 microEin m-2 s-1), and artificial seawater.


Input: A genomic DNA clone encoding oryzacystatin (Oc), a cysteine proteinase inhibitor (cystatin) of rice, was isolated from a lambda EMBL3 phage library constructed with Sau3AI partial digests of rice chromosomal DNA, by screening with an oc cDNA as a probe.

oryzacystatin

Oc

cysteine proteinase

cystatin

oc cDNA


Input: The use of an appropriate solution of methylene blue (0. 2% in 0. 9 M NaCl for 15 min) permits the staining of premalignant areas and CIS, and their early diagnosis.


Input: Lower limits (to 10 micrograms/kg) were detectable, but with lower reliability (60%).


Input: Instead, some small negative effects are observed, particularly involving effects of husbands' retirement on the marital satisfaction of employed wives.


Input: This in turn will further enhance the role of meta-analysis in helping clinicians and policy makers answer clinical questions.


Input: The accuracies of presence or absence of neuroblastoma were compared between 131I-MIBG imaging and several tumor markers.


Input: The congenital forms (7 cases) all occurred in female infants and involved the mucosa overlying either the anterior ridge of the maxilla or the mandible.


Input: Immunohistochemical studies revealed positive staining for S100 protein in all the granular cell tumors of the adult but in none of the congenital granular cell epulides.

S100 protein


Input: We also found that the same males, breeding in different years on the same territories, had significantly larger harems in the years they had familiar neighbors.


Input: Male-enhanced antigen gene is phylogenetically conserved and expressed at late stages of spermatogenesis.

Male-enhanced antigen gene


Input: In rats bearing Walker-256-carcinosarcoma 4-EPI was effective. (ABSTRACT TRUNCATED AT 250 WORDS)


Input: Pacing the Roux limb abolished the ectopic pacemakers, restored the slow emptying of liquids to the more rapid rate found in the Billroth dogs (t1/2: paced Roux, 72 +/-15 minutes; Billroth, 43 +/-9 minutes; p greater than 0. 05) and did not change emptying of solids.


Input: The treatments were 60 mg t. i. d. and 120 mg t. i. d. during 14 days' treatment, with the last dose pulsed with 1. 85 MBq [14C] diltiazem.


Input: The subepicardial lymphatic capillaries were ramified and anastomosed with each other to form a relatively dense network which extended over the entire surface of both ventricles.


Input: The examination must include T1 and T2 sequences and scans in three planes.


Input: A great deal of information is available on the morphology of the claustrum in various animal species, as well as on its neuronal distribution and relationships with the cerebral cortex and other nuclei.


Input: Low-grade glioma.


Input: In terms of sequence repetitions, seven tandemly repeated copies of the hexanucleotide ATTGTT and three flanking regions of dyad symmetry were detected, all in ORF T3C.


Input: The significance of these palindromic domains in this ORF is unclear but the coincidence of the end of one larger palindrome with the end of the translated protein sequence that has homology with the B chain of insulin suggests that the palindromes may divide the T2 protein into several functional units.

insulin

T2 protein


Input: During sub-maximal exercise, DCR in the UT dogs decreased from a resting value of 4. 08 +/-0. 18 mm Hg X ml-1 X min-1 to 1. 91 +/-0. 17 mm Hg X ml-1 X min-1 at a workload of 6. 4 kph (speed)/16% (grade).


Input: These data suggest that the G-protein gene family may be distributed over at least two human chromosomes.

G-protein gene family


Input: The major inserted DNA has no significant homology to published human nucleic acid sequences.


Input: We have also found that the in vitro interaction between the SV40 octamer motif and the lymphoid cell-specific protein oct-B2 was negatively modulated by a component present in the nuclear extracts from several lymphoid cell lines.

lymphoid cell-specific protein oct-B2


Input: Anoxia was introduced by perfusing the gill with water deprived of oxygen or by halting the water flow to the gill.


Input: Growth, 4-PA and 14C turnover data indicated that WB contributed to B-6 intake of these rats.


Input: DNA sequence analysis revealed that these clones encode two distinct forms of translocase.

translocase


Input: RPA190 encodes a polypeptide chain of 186, 270 daltons in a large uninterrupted reading frame.


Input: Both the intact A1 protein and its proteolytic fragment, the UP1 protein, can be cleaved by Staphylococcus aureus V-8 protease to produce two polypeptides of 92 amino acids.

intact A1 protein

UP1 protein

Staphylococcus aureus V-8 protease


Input: Irmiere, and W.


Input: These offspring of the alpha-MSH treated mothers were less sensitive to pain and as adults showed a reduced analgesic response to morphine.

alpha-MSH


Input: Simian immunodeficiency virus (SIV) is a lentivirus with morphological and antigenic similarities to human immunodeficiency virus, the causative agent of acquired immunodeficiency syndrome (AIDS) of humans.


Input: The lack of change in the ratio of the two spliced products expressed from either the normal or the 5'-rearranged myb further indicates that the insertion of the unique 121 amino acids in the larger myb transcripts is not a consequence of tumor-specific activation of the mouse myb oncogene.

5'-rearranged myb

myb transcripts

mouse myb oncogene


Input: The use of CRF-41 in the differential diagnosis of Cushing' s syndrome and obesity.


Input: We detected mos transcripts by Northern (RNA) analyses in RNA prepared from chicken and quail ovaries and testes.

mos transcripts


Input: The results suggest that the organization of functional units of the 72-bp repeat required for transcriptional enhancement of the early promoter is different from that required for late promoter function.


Input: Variations in the 5' half of U3 were primarily due to insertions and deletions.


Input: An analysis of the steady state RNA levels in T-lymphoid cell lines showed that at least three different incomplete proviral transcripts and their spliced products made up the majority of expressed RD-114 mRNA, and further demonstrated that partially deleted proviral loci have the potential to be transcriptionally vigorous in certain feline cell types.

RD-114 mRNA


Input: Either two or more different sequences can promote cleavage, or a single element exists which is long and diffuse.


Input: Low molecular weight heparins have stimulated much interest because of their supposedly more selective action on Xa factor.

Xa factor


Input: Sodium dodecyl sulphate-induced cleavage by eukaryotic topoisomerase I is known to yield enzyme covalently attached to the 3' cut end of the DNA.

eukaryotic topoisomerase I


Input: Amino acid sequence of one human liver clone (HL-14) was identical to the rabbit skeletal muscle phosphatase 2A cDNA (with 97% nucleotide identity).

rabbit skeletal muscle phosphatase 2A cDNA


Input: Herpes virus infection was characterized by inversion of the T4/T8 ratio below 1. 0 (sensitivity 90%, specificity 88%), caused by proliferation of the T8 subpopulation, which--compared with the findings in patients with rejection crises--was significantly raised (P less than 0. 001).


Input: Quantitative assays in which the activity of the synthetic alpha s-1 was compared to that of native purified human erythrocyte type-1 Gs, indicated that the two products are equipotent within a 2-fold margin of error.

synthetic alpha s-1

human erythrocyte type-1 Gs


Input: In these cells, E2 proteins had little or no stimulatory effect on the transcriptional activity of the HPV-11 enhancer-SV40 promoter.

E2 proteins

HPV-11 enhancer

SV40 promoter


Input: The mechanism by which E2-C represses E2-dependent enhancer activity most likely involves competition with E2 for binding to a common transcriptional regulatory site. (ABSTRACT TRUNCATED AT 400 WORDS)

E2-dependent enhancer


Input: Accurate evaluation of the treatment results in unresectable lung cancer patients must take the strong prognostic factors into account.


Input: (anti-IIa) and Holmer et al.

anti-IIa


Input: Introduction of v-fms into a CSF-1 dependent murine macrophage cell line induced factor independence and tumorigenicity by a nonautocrine mechanism.

v-fms


Input: Chronic E-B virus infection terminated in malignant lymphoma: a case report


Input: Whereas the muscle isoform consists of 997 amino acids and terminates with the sequence Ala-Ile-Leu-Glu, the second isoform is 1043 amino acids in length due to the replacement of these last 4 amino acids with a 50-amino acid sequence that contains a potential transmembrane domain followed by a consensus sequence for an N-linked glycosylation site.


Input: Substitution of a threonine residue by an alanine residue at position-2 (P2) of this cleavage site abolished cleavage, whereas substitution of a tyrosine residue by a phenylalanine residue at amino acid position-1 (P1) of the cleavage site did not influence processing.


Input: A highly hydrophobic sequence located near the carboxyl-terminal extremity of the molecule most likely constitutes the anchor to the plasma membrane.


Input: The SV40 enhancer augmented replication 1. 5-10 fold.

SV40 enhancer


Input: One of these, the origin core, is required only for DNA replication.


Input: Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element.

proto-oncogene fos

adenylate cyclase


Input: A 17-mer oligodeoxynucleotide, corresponding to a region of the VtHb amino acid sequence was used as a hybridization probe to screen a Vitreoscilla genomic library constructed in broad-host-range cosmid vector pVK102.

VtHb amino acid sequence


Input: (total soluble solids) and organoleptic characteristics under the influence of different treatments.


Input: Causes of death found in an epidemiological study of native chickens in Thai villages.


Input: The progression of non-A, non-B hepatitis to chronic diseases, and the transformation to hepatocellular carcinoma


Input: Elevated IOP developed in 35 patients (44 eyes) during the study.


Input: Use of serum thyroglobulin determination in the follow-up of differentiated carcinomas of the thyroid

thyroglobulin


Input: Poor response when laboratory recommended range for serum lithium is changed.


Input: The aim of this study was to investigate the effects of nebulized ipratropium in patients with acute asthma in order to determine whether it augments the bronchodilator effect of a beta agonist drug.


Input: Further analysis of this DNA fragment showed that four genes are present encoding proteins of 16, 18. 5, 21 and 89 kDal.


Input: Hantaan virus.


Input: Changes in dopamine receptor sensitivity in humans after heavy alcohol intake.

dopamine receptor


Input: No significant differences between the two treatment groups were found, but rapid responders had a smaller mean initial platelet-associated IgG index which returned more rapidly and more permanently to normal than that of slow responders.

platelet-associated IgG


Input: Replacement variant histone genes contain intervening sequences.

Replacement variant histone genes


Input: Double-blind randomised trial of intravenous tissue-type plasminogen activator versus placebo in acute myocardial infarction.

tissue-type plasminogen activator


Input: The C-terminal domains (CTDs) of the RPase beta subunit and DNA primase (dnaG protein) were not only strongly homologous to each other but also considerably homologous to the RPase alpha, suggesting that an alpha subunit-like enzyme must have been commonly ancestral to core enzyme subunits and primase.

RPase beta subunit

DNA primase

dnaG protein

RPase alpha

core enzyme subunits

primase


Input: However, vancomycin and fosfomycin, which revealed suboptimal in vitro bactericidal activity, proved as efficacious as penicillin G and imipenem in an experimental mode of murine gas gangrene.


Input: Fentanyl, a prototypic mu-opiate receptor agonist, has been previously shown to produce a syndrome characterized by marked analgesia and locomotor stimulation as well as tachycardia, tachypnoea and behavioural arousal.

mu-opiate receptor


Input: Bisoprolol was found to be an effective beta-adrenoceptor antagonist, the pA2 values determined against isoprenaline in guinea pig atria and tracheal muscle being 7. 45 and 6. 41, respectively.

beta-adrenoceptor


Input: Output of 99mTcO-4 by the parotid gland closely mimicked fluctuations in parotid saliva flow rate.


Input: The Hagen-Poiseuille equation is used to assess the effects of attached parasites in the foregut of Leishmania-infected sandflies on blood flow.


Input: Moreover, in rats allowed to choose in a T-maze between immediate-but-small vs. delayed-but-large reward, BZP significantly decreased the frequency with which the delayed reward was chosen, with 5-HT uptake blockers producing opposite effects.


Input: An endometrial luteal phase deficiency was detected in 15 (30%) of aborting patients.


Input: Prenatal exposure to the fungicide dinocap causes behavioral torticollis, ballooning and cleft palate in mice, but not rats or hamsters.


Input: Reperfusion with normal blood in the beating, working hearts caused extensive structural damage, reduced reflow, and failed to restore contractility in any instance (-27% systolic shortening, p less than 0. 05).


Input: The sensitivity of the vas deferens to adrenaline was also reduced in scorbutic guinea pigs, thus decreasing their fertility rate.


Input: In metabolic acidosis there was a marked stimulation when clamped at-10 to-100 mV.


Input: On Days 1 and 14, most young and elderly subjects exhibited monoexponential decline in bevantolol plasma concentrations after absorption phase.


Input: Mature and old B6AF1 and B6D2F1 mice were given acidified tap water or promethazine HCl (a phenothiazine with H1 receptor blocking activity), chlorpheniramine (an H1 blocker) or trifluoperazine (a phenothiazine with no H1 blocking activity) in their drinking water, and the effects of these agents on bone mineral content were assessed by intermittently measuring the 24-h whole body retention of Tc 99m methylene diphosphonate (Tc 99m MDP, an indicator of bone metabolism) and at the end of the studies by determining ash weights of femur, ilium and sacrum.

H1 receptor


Input: Present results reveal a frequency-dependent inhibition of ganglionic transmission by diltiazem, and suggest that diltiazem may depress excessive sympathetic activity without affecting normal ganglionic transmission.


Input: Effects of a new antihypertensive agent, SGB-1534, on rat platelet aggregation.


Input: Since the stability of TF1 resides in its primary structure, we cloned a gene coding for TF1, and the primary structure of the beta subunit was deduced from the nucleotide sequence of the gene to compare the sequence with those of beta' s of three major categories of F1' s; prokaryotic membranes, chloroplasts, and mitochondria.


Input: Body temperature and overall conductance in the cold appear to be more variable in P. s. campbelli than in nominative sp.


Input: A drug with ISA " down regulates " beta receptors; thus, when the drug is withdrawn there is no post-beta-blocking drug hypersensitivity in contrast to agents without ISA.

beta receptors


Input: Six patients with human T-cell lymphotropic virus type I (HTLV-I)-associated myelopathy (HAM) were studied by electrophysiologic methods.


Input: Terazosin, a structural analog of prazosin, also inhibits alpha 1 adrenoceptors and is recommended as once or twice-daily therapy.

alpha 1 adrenoceptors


Input: Testing blood donors for non-A, non-B hepatitis: irrational, perhaps, but inescapable.


Input: Most patients with high blood pressure (BP) can be managed by using one of 4 classes of compounds: a diuretic, beta blocker, converting enzyme inhibitor or calcium antagonist.


Input: In a randomised double-blind study, 46 first episode schizophrenics were given pimozide or flupenthixol for up to 5 weeks; the mean daily dose at the end was 18. 8 mg pimozide and 20 mg flupenthixol.


Input: Somatostatin-producing endocrine pancreatic tumor in Recklinghausen' s neurofibromatosis.

Somatostatin


Input: Direct and inverted repeat elements of 10, 11, 16, 19, and 22 nucleotides (nt) flank the promoter site.


Input: We have been able to map specific DNA fragments at the bases of chromatin loops with the help of a novel extraction procedure by using lithium-3', 5'-diiodosalicylate.


Input: Seventy-one supplementary doses of vecuronium were used for muscle relaxation during a 22-h-long NLA II anaesthesia.


Input: Finally, the recovery indexes represented by the times required for T1/T0 and T4/T1 to rise from 25% to 75% respectively were studied.


Input: Transformed bacterial colonies were screened for recombinant plasmids containing cDNA coding for BiP by hybrid-selected mRNA translation.

BiP


Input: DPA attenuated the increase of the intensity of the ischemic and pressure pain components with increasing ischemia duration, but only the effect on the pressure pain component was significant.


Input: Topical 1 percent isoproterenol in the presence of the phosphodiesterase inhibitor theophylline was tested for its ability to stimulate the rate of aqueous humor flow through the anterior chamber of the normal and the partially adrenergically denervated human eye (Horner' s syndrome).


Input: Hyperthyroidism is one of the numerous causes of infertility and recurrent abortion.


Input: A strong correlation exists between the numbers of CFU-GM transfused and the rate of granulocytes and platelets recovery.


Input: Oestrogen implant overdose.


Input: Three sequence elements are shown to be required for accurate and efficient transcription termination by RNA polymerase I (pol I) assayed both in a cell-free transcription system and in vivo after transfection of rDNA minigene constructs into 3T6 cells.

RNA polymerase I

pol I


Input: A new physiopathological treatment of HBV-related polyarteritis inspired by advances in the treatment of chronic active hepatitis B was tested in 7 patients.


Input: The subunit-a gene is preceded by a gene coding for a small hydrophobic protein, as has been observed previously in the atp operons in E. coli, bacterium PS3 and cyanobacteria.

subunit-a gene

atp operons


Input: Here, we describe the isolation of bovine and rat GHF-1 cDNA clones.

bovine and rat GHF-1 cDNA


Input: To explore the functional properties of the protein encoded by neu, we created a fusion gene that joins the cytoplasmic domain of neu to the extracellular portion of an immunoglobulin heavy chain.

neu

neu

immunoglobulin heavy chain


Input: By sequence comparison, 42 blocks of homology are defined in the 5'-terminal region, of which 36 appear in the CpG island and contain numerous conserved CpG dinucleotides.


Input: Among unusual features, we report numerous large G + C-rich conserved sequences located in the first intron.


Input: In the first group, 0. 02% Prazosin (0. 5 mg/kg) was administered intravenously for 1. 5 hours before the application of Oxy-Hb or PGF2 alpha.


Input: A decamer sequence, 5'-CGA-CCCCUCC-3', complementary to a conserved sequence adjacent to the enzymatic cleavage site on the mitochondrial RNA substrate, is present in the RNAase MRP RNA.

RNAase MRP RNA


Input: Effects of aging and beta-adrenergic-blockade on standing-induced QT/QS2 changes.


Input: A patient with an infected wound or one on a primary area (hands, feet, face, or perineum) may have to be hospitalized to ensure proper care.


Input: Pharmacology studies with potassium chloride and acetylcholine suggest that raveron acts as a calcium antagonist by blocking the influx of extracellular calcium.


Input: On admission to the ICU, 117 patients (61 percent) had hypomagnesemia (serum Mg less than 1. 5 mEq/dl), 66 patients (34 percent) had normomagnesemia (1. 5 to 2. 0 mEq/dl), and ten patients (5 percent) had hypermagnesemia (greater than 2. 0 mEq/dl).


Input: The risk factors studied were male sex, hypertension, diabetes mellitus, hypercholesterolemia, cigarette smoking, sedentary life-style, and family history.


Input: Neither verapamil nor nifedipine changed collateral myocardial blood flow from 0. 10 +/-0. 02 in the subendocardium and 0. 17 +/-0. 03 ml/min/g in the subepicardium.


Input: There were 35 boys and 15 girls, with a mean age of five and a half years.


Input: Controlled versus uncontrolled reperfusion of ischemic myocardium after experimental coronary artery occlusion was studied to determine the effect on regional ventricular wall motion and associated biochemical alterations.


Input: Cardiac disease was not detected with M-mode, 2-dimensional real-time or pulsed-wave Doppler echocardiography.


Input: Hemodynamic assessment was obtained before and following administration of digoxin 10 micrograms/kg IV or dopamine, 5 to 12 micrograms/kg/min IV.


Input: We conclude that at these low levels studied, aluminum accumulates in intestinal tissue, and that this accumulation is enhanced by citrate ligand.


Input: Thus, the effects of father absence under routine conditions in relatively healthy samples may exert no significant effects independent of intervening family stressors or maternal psychopathology.


Input: Recently, an electrical-mechanical analog model of heat flow within the brain has been developed from which an expression for CBF has been derived: CBF = Cb/(tau rho c) where tau is the thermal decay constant, rho is the density of blood, and c is its specific heat.


Input: All of the newly acquired proviruses identified in mosaic founder SWR/J-RF/J mice that could be transmitted through the germ line were also present in somatic tissues, demonstrating that viral integration occurred before the germ line was set aside from the somatic lineages.


Input: Molecular cloning of the cDNA for the human U2 snRNA-specific A' protein.

human U2 snRNA-specific A' protein


Input: For the present work we used water saturated with a 50/50 mixture of H2 and O2 gases, for which the heat defect is calculated to be-2. 1%.


Input: During flexion whiplash, the torque at the occipital condyle reverses its direction at about 25 ms after impact.


Input: The data indicates the presence of 5-HT2 serotonergic receptors in the bronchial artery of these species.

5-HT2 serotonergic receptors


Input: Oxfendazole, which was active for the shortest time (about 65 days) from the start of grazing (May 1), produced a 78. 1 per cent reduction in Ostertagia species and an 84. 4 per cent reduction in D viviparus.


Input: By adapting a method for DNA-footprinting using impure extracts of ner overproducing cells, we were able to determine that the ner-binding sites are located between nucleotides 1026 and 1058 from the Mu left end.

ner

ner-binding sites


Input: Platelet function and platelet-polymorphonuclear-neutrophil interaction in patients with deficient platelet lipoxygenase activity.

platelet lipoxygenase


Input: Spontaneous degradation of atracurium in plasma is the major route of elimination in man and contributes to a short elimination half-life (approximatively 20 min).


Input: Transformed cell lines expressing solely E1a or E1a and E1b gene products derived from these viruses display enhanced anchorage-independent growth at 37 degrees C versus 32 degrees C and display a cytoskeletal architecture resembling untransformed fibroblastic CREF cells.

E1b gene products


Input: Partial N-terminal amino acid sequence analysis showed that the 43K and 42K T antigens contain methionine at residues 1 and 5, as predicted from the DNA sequence, whereas no methionine was released from the 39K T antigen during the first six cycles of Edman degradation.

43K and 42K T antigens

39K T antigen


Input: Group A was treated with three or four doses of hepatitis B immune globulin (HBIG) in one of three different schedules.

hepatitis B immune globulin

HBIG


Input: In the former instance, in addition to serum calcium and phosphorous ion concentrations, tissue pH, blood supply, hormones, i. e., vitamin D, vitamin A, and various enzymes (e. g., alkaline phosphatase and pyrophosphatase) may all play significant, ancillary, time-dependent, but as yet undetermined roles.

alkaline phosphatase

pyrophosphatase


Input: Penicillinase production in Staphylococcus aureus strains of clinical importance.

Penicillinase


Input: Thus, quantitative analysis of thallium-201 uptake and washout provided objective evidence for improved myocardial perfusion after coronary angioplasty.


Input: This study reports the effects of a preparation with 50 micrograms ethinyl estradiol and 2 mg cyproterone acetate on gonadotropins, prolactin, testosterone, sex hormone binding globulin (SHBG), androstenedione, and calculated free testosterone index before and after six months of treatment.

gonadotropins

prolactin

sex hormone binding globulin

SHBG


Input: In nine patients with renal failure routine haemodialysis was accompanied by a 30 per cent reduction in plasma ANP concentration.

ANP


Input: To investigate the effects of isotretinoin on HDL, we measured HDL-C, HDL phospholipids (HDL-PL), apoprotein A1 (apo A-1), and HDL-C subfractions (HDL2-C and HDL3-C) in 24 healthy, male patients receiving a 16-week course of isotretinoin (1. 0 mg/kg/day) for treatment of severe acne vulgaris.

HDL

HDL-C

HDL

HDL-PL

apoprotein A1

apo A-1

HDL-C


Input: The clinical picture and laboratory parameters were consistent with a serum sickness reaction.


Input: Preventive effect of ONO-3708 on thrombosis and vasospasms in vitro and in vivo.


Input: The frequency of PPNG strains increased from 1. 7% in 1981 to 6. 7% in 1985.


Input: Monospecific antibodies, eluted from the beta-galactosidase fusion protein of either clone reacted with the U1 snRNP-specific A antigen.

beta-galactosidase

U1 snRNP

A antigen


Input: The pathogenesis of Limited Joint Mobility (LJM) in diabetes is unknown, but the abnormality is said to be associated with an increased incidence of microangiopathy.


Input: The experimental end points were the time required for treated tumors to reach 3 times their treatment size, the survival of stem cells in the duodenal crypts, and the breathing rate measured early (19-23 weeks) and late (41-46 weeks) after treatment.


Input: Schedule 2, in which 2. 4 mg/kg c-DDP was administered immediately before X-ray on 5 consecutive days produced the highest degree of enhancement of radiation effect (expressed as dose-effect factor); and the next greatest enhancement was produced by 12 mg/kg c-DDP administered 24 h before the start of fractionated daily radiotherapy.


Input: The cpc-1-encoded transcript contains three open reading frames, two of which are located in the 720-nucleotide leader segment preceding the cpc-1 coding region.

cpc-1-encoded transcript

cpc-1 coding region


Input: The HOI induced a nearly fourfold increase in ANF in the elderly, whereas that for the young was threefold.

ANF


Input: To assess the ability of the atria to maintain elevated plasma concentrations of atrial natriuretic peptide (ANP), the temporal changes in plasma ANP concentrations were studied in seven chloralose-anaesthetized dogs during 4 h of sustained rapid cardiac pacing.

atrial natriuretic peptide

ANP

plasma ANP


Input: Ig D-JH recombinations may precede TcR gene recombination in these early T cell lines, and some but not all express sterile Cmu transcripts.

Ig D

JH

TcR gene

Cmu transcripts


Input: The RAD18 gene open reading frame encodes a protein of 487 amino acids, with a calculated molecular weight of 55, 512.

RAD18 gene open reading frame


Input: Atomic absorption spectrophotometry applied to bacterially expressed E1A proteins revealed that the 289-amino acid protein binds one zinc ion, whereas the 243-amino acid protein binds no zinc.

E1A proteins


Input: Most patients preferred tablets to injection both on day 1 (313 v 200) and at follow up (373 v 104).


Input: Plots of RV, LV + S and 2A weight vs real hematocrit showed sharp upward inflections at real hematocrit 65%, suggesting a possible role of increased viscosity in CO cardiomegaly at the higher hematocrit.


Input: The absorbable perisplenic mesh is an important improvement, and in some cases it may replace other techniques for arresting splenic bleeding.


Input: A rare chronic course of Budd-Chiari syndrome associated with thrombosis of the portal vein was observed in a 30-year-old male patient suffering from postmyocarditic cardiosclerosis.


Input: After one accommodation night, sleep EEG recordings were performed during three consecutive nights in ten drug-free inpatients presenting generalized anxiety disorder (GAD) with significant depression, compared with a age-and sex-matched group of patients with GAD and a group of primary major depressive disorder (MDD) patients.


Input: Oligonucleotide mutagenesis of these binding domains indicated their importance in the transcriptional regulation of the E3 promoter in yeast cells.

E3 promoter


Input: The concentration of PGI2 on the newly-formed luminal surface remained low.


Input: Effects of single and combined maltose tetrapalmitate immunotherapy, cyclophosphamide chemotherapy and radiotherapy on ethyl carbamate accelerated primary lung cancer in A/J mice.


Input: D.


Input: Phase II study of VP-16 (capsule) in solid tumors.


Input: When the coding segments, including both framework and complementarity-determining regions, of these genes and the murine probe sequences are compared by metric analysis, it is apparent that the caiman genes are only slightly more related to each other than to the mammalian sequence, consistent with significant preservation of nucleotide sequence over an extended period of phylogenetic time.


Input: An unusual feature of these replicative genes is that the smaller mRNA begins within a long open reading frame of the larger mRNA.


Input: Different sequence elements of both the retroviral vectors and the c-myc gene recombined during genesis of highly oncogenic retroviruses CMII, MC29, or MH2.

c-myc gene


Input: 81 milk samples collected from 35 donors 3 days to 7 months after delivery were examined for the occurrence of cytomegalovirus (CMV).


Input: Subcloning of DNA fragments from the 8. 5-kilobase (kb) insert of pAVO4 defined a 4-kb DNA fragment which contained the functional FBP + gene and its regulatory region.

functional FBP + gene


Input: Three cases of primary signet-ring cell carcinoma of the rectum are described.


Input: The data obtained up to now only suggest the future potentiality of Bestatin treatment for these types of malignancy.


Input: These data suggest that dopaminergic regulation of adrenal zona glomerulosa corticosteroid and renal renin secretion is absent in patients with high spinal cord transections, suggesting that intact neural pathways from the central nervous system are necessary for metoclopramide stimulation of aldosterone and renin secretion in men.

renal renin

renin


Input: In the absence of enhancer sequences, the adenovirus E1A gene can not stimulate CATase synthesis.

adenovirus E1A gene

CATase


Input: These IgG antibodies in the babies diminished rapidly after delivery, and were detectable only in 3 cases at 2, 3, and 5 months of ages out of 38 babies up to 21 months.

IgG antibodies


Input: Fine analysis at the nucleotide level of the early events in the digestion with nuclease S1 shows that the enzyme attacks preferentially the sequence (G-A) 12 on the message complementary strand.

nuclease S1


Input: Those dosages that inhibited mean NTE activity in spinal cord greater than or equal to 72% and brain greater than or equal to 66% of control values within 44 hr postexposure produced marked spinal cord pathology 14 days postexposure in greater than or equal to 90% of similarly dosed animals.

NTE


Input: FK 33-824, a methionine-enkephalin analogue, suppressed plasma ACTH to 85% of basal level, while bromocriptine (CB-154) caused no significant change.

enkephalin

ACTH


Input: A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.

v-erbB-related protooncogene

epidermal growth factor-receptor


Input: The sequence analysis of both products of individual phi 80 site-specific recombination events in vivo shows that recombination with a secondary attachment (att) site generates several different novel joints at the mismatched position: one recombination event resulted in a single base-pair deletion and two other recombination events resulted in two different single base-pair substitutions.


Input: This L-myc sequence is amplified 10-20-fold in four SCLC cell line DNAs and in one SCLC tumour specimen taken directly from a patient.

L-myc sequence


Input: Temperature-shift experiments using synchronously grown cells of a delta top1 top2 temperature-sensitive (ts) double mutant and its isogenic top2 ts strain show that, whereas mitotic blocks can prevent killing of the top2 ts mutant at a nonpermissive temperature, the same treatments are ineffective in preventing cell death of the delta top1 top2 ts double mutant.

delta top1 top2 temperature-sensitive (ts) double mutant

top2 ts mutant

delta top1 top2 ts double mutant


Input: The homology to v-mil starts within the coding sequence of exon 1 and ends within the 3' untranslated region of exon 11, 12 nucleotides downstream from the nonsense codon terminating the large open reading frame shared between c-mil and v-mil.

v-mil

c-mil

v-mil


Input: Examination of the sequence of the Punta Toro M gene product reveals the presence of multiple hydrophobic sequences including a 19-amino acid, carboxy-proximal, hydrophobic region (G2).

Punta Toro M gene product


Input: Six (four FAP; two primary amyloidosis) also had diffusely positive myocardial uptakes, but the intensity was less than that of the sternum.


Input: The intensity of myocardial uptake of Tc-99m-PYP in patients with echocardiographic left ventricular hypertrophy and/or highly refractile myocardial echoes, so-called granular sparkling appearance (GS) was slightly greater than that in patients with neither myocardial hypertrophy nor GS.


Input: Alveolar lymphocytes were surprisingly increased in most patients with AIDS (mean 26. 1 +/-21. 9%; range 1-76%) and CGL (mean 26. 6 +/-22. 6%; range 3-76%) with criteria of activation contrasting with the blood lymphopenia.


Input: We have determined that these nicks occur in both the wild-type and the mutant sites.


Input: The sequence was determined for a 4024-base pair (bp) segment that extends from 149 bp 5' to the cap site of alpha 1 to 207 bp 3' to psi alpha.

alpha 1

psi alpha


Input: When phosphorylation of exogenous peptide substrates was measured as a function of receptor self-phosphorylation, tyrosine kinase activity was found to be enhanced two to threefold at 1-2 mol of phosphate per mol of receptor.

tyrosine kinase


Input: The pet56 and his3 genes are transcribed divergently from initiation sites that are separated by only 192 bp.

his3 genes


Input: It is concluded that in patients with first-attack genital herpes, the type of HSV is the most important determinant of subsequent recurrences and that intravenous acyclovir has little effect on subsequent recurrences.


Input: Comparison of sequences of ovine and bovine, rat and guinea-pig alpha s1-casein mRNAs has revealed a greater homology in the 3' and especially 5' non coding regions.

guinea-pig alpha s1-casein mRNAs


Input: Comparison with a recently described c-sis cDNA clone (Collins et al., Nature 316, 748-750 (1985)) revealed that the 1. 9 kbp DNA region contained a large 5' c-sis exon of at least 1050 bp.

c-sis cDNA clone

5' c-sis exon


Input: It was also suggested that the biological activities of 5-FU, ADM and MMC in FAMLIP were stable in FULIP, ADRLIP and MMCLIP.


Input: Surprisingly, a C to G transversion at the first residue of the CAT pentanucleotide, which severely impairs the activity of both promoters, appears to increase affinity of the CAT binding protein.

CAT pentanucleotide

CAT binding protein


Input: The nucleotide sequence of 3874 bp of cloned R. sphaeroides chromosomal DNA, including the three structural genes fbcF, fbcB and fbcC has been determined.

fbcF

fbcB

fbcC


Input: The N-terminal sequence of one hydrophilic peptide of the FeS protein has been also obtained confirming the fbcF reading frame.

FeS protein

fbcF


Input: The 5' and 3' untranslated sequences contain characteristic sequences that are involved in the initiation and termination of transcription, including two possible promoters, one of which may contain two overlapping-10 sequences.


Input: Unlike P135gag-myb-ets and the Mr 75, 000 translation product of c-myb (P75c-myb), which are nuclear proteins, P54c-ets was found to be predominantly cytoplasmic.

myb

ets

c-myb


Input: The Dox-A2 locus is within 3. 4 to 4. 4 kb of the Df (2L) OD15 breakpoint, placing four of the vital loci within a maximum of 15. 5 kb.

Dox-A2 locus

Df (2L) OD15 breakpoint


Input: The C-terminal end of this polypeptide harbors three types of repeated sequences.


Input: Further outbreaks of ocular disease in farmed red deer calves caused by HVC-1 were investigated.


Input: From our ultrastructural and biochemical studies, it is evident that Type II pneumocytes are an early target of radiation and the release of surfactant into the alveolus shortly after exposure persists for days and weeks.


Input: Thirty of the clones contained a complete 340 base-pair dimer unit of the repeat.


Input: Two copies of the 72-bp repeat provided efficient activation of gene expression.


Input: The open reading frames of rbsD, rbsA, and rbsC encode proteins of 139, 501, and 321 amino acid residues, respectively.

rbsD

rbsA

rbsC


Input: Cattaneo, and J.


Input: Human alpha-galactosidase A: nucleotide sequence of a cDNA clone encoding the mature enzyme.

Human alpha-galactosidase A


Input: The amino acid sequence was determined to be residues 716-724 and hence lysine residue 721 is located within the ATP-binding site.


Input: Osteocalcin (and urinary hydroxyproline) were not elevated in isolated hyperphosphatasaemia, indicating that mechanisms other than increased bone turnover may account for the markedly elevated serum alkaline phosphatase activity in these subjects.

Osteocalcin

serum alkaline phosphatase


Input: Analysis of glucocorticoid unresponsive cell variants using a mouse glucocorticoid receptor complementary DNA clone.

mouse glucocorticoid receptor


Input: Among the v-myc codons, the first 5 are derived from the noncoding 5' terminus of the second c-myc exon, and 412 codons correspond to the c-myc coding region.

v-myc

c-myc

c-myc


Input: A recombinant vector, p410 +, was constructed which carried the BamHI-K fragment (nucleotides 107565 to 112625 of the B95-8 strain, encoding the EBV-associated nuclear antigen EBNA-1), the cis-acting sequence from the BamHI-C fragment, and a dominant selectable marker gene encoding G-418 resistance in animal cells.

BamHI-K fragment

BamHI-C fragment


Input: 13 men with a history of recurrent genital herpes simplex virus type 2 (HSV-2) infection were followed daily for 4 weeks with samples taken from the urethra for virus isolation.


Input: Next, with carcinoma presenting a leather bottle (linitis plastica type) of the stomach itself, the II c portion of the stomach consisted of fundic glands (undifferentiated carcinoma) shall become the primary focus supporting Nakamura' s theory.


Input: During the biosynthesis of all three mutant polypeptides, the signal peptide is efficiently and accurately cleaved from the nascent protein, even though in mutants X2 and X3 the cleavage site itself has been altered.


Input: The hexanucleotide 5'-TGTCCT-3', thought to be important for GRE activity, not only was found in this sequence and in the 5'-flanking region, but also was present twice in the 3' end of the gene that did not show specific receptor binding.


Input: The smallest of the mini-Mu elements is only 7. 9 kilobase pairs long, allowing the cloning of DNA fragments of up to 31. 1 kilobase pairs, and the largest of them is 21. 7 kilobase pairs, requiring that clones carry insertions of less than 17. 3 kilobase pairs.


Input: The 52-protein subunit of T4 DNA topoisomerase is homologous to the gyrA-protein of gyrase.

T4 DNA topoisomerase

gyrA-protein

gyrase


Input: The latent periods from the antral exclusion to the occurrence of anastomotic ulcers after a subtotal gastrectomy with Billroth' s type II reconstruction varied from a few days to 19 years, with an average of 2. 8 years.


Input: The nucleosomal arrays detected by MPE X Fe (II) were characterized by a considerable loss of detail and significantly enhanced accessibility, the extent of which probably reflected the relative transcription rate of each gene.


Input: The molecular weight of in vivo-labeled proteins was increased relative to that of in vitro-translated proteins, indicating that a posttranslational modification had occurred.


Input: Insertion of 4 bp reduced SV40 early promoter-dependent chloramphenicol acetyltransferase (CAT) expression by six-to eightfold.

SV40 early promoter

chloramphenicol acetyltransferase

CAT


Input: In the DNAs of all Ph1-positive chronic myelocytic leukemia patients studied to date, a breakpoint on chromosome 22 (the Ph1 chromosome) can be demonstrated with a probe from the bcr (breakpoint cluster region).

bcr

breakpoint cluster region


Input: Nuclease footprinting revealed that purified glucocorticoid receptor bound at multiple discrete sites within and at the borders of the tandemly repeated sequence motif that defines Sa.

glucocorticoid receptor

Sa


Input: The 96-bp insert contained a termination signal which caused the premature termination of the protein, leading to the generation of a p53 product 9 amino acids shorter than usual.

p53 product


Input: All tumors proved histologically to be neuroendocrine in origin.


Input: The coding region of 2385 nucleotides corresponds to a polypeptide chain of 795 amino acids, giving a molecular weight of 91, 555 for the hsp108 protein.

hsp108 protein


Input: Transcriptional control signals of a herpes simplex virus type 1 late (gamma 2) gene lie within bases-34 to + 124 relative to the 5' terminus of the mRNA.

herpes simplex virus type 1 late (gamma 2) gene


Input: A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps.

cytoplasmic protein-tyrosine kinases

Fujinami sarcoma virus P130gag

fps


Input: Gluzman, EMBO J.


Input: A single exon encodes the carboxyl-terminal 26 amino acids of the ssd chain and the 3' untranslated region of its mRNA, ending with a poly (A)-addition site.

ssd chain


Input: The 5'-nontranslated sequences and parts of the coding sequences of various yeast genes have been cloned into representative lacZ fusion vectors.

lacZ


Input: Two activities of the D protein of the miniF plasmid have been found.

D protein


Input: SPECT examination of the TMJ using 99m Tc-MDP was performed in 43 patients with arthrographically proven anterior dislocation of the disc and in 30 normals.


Input: Plasma renin activity rose and the plasma aldosterone level fell after taking lisinopril.

Plasma renin


Input: The second group of homologous elements is present in the upstream region of both genes.


Input: Constitutive function of a positively regulated promoter reveals new sequences essential for activity.


Input: We inserted genes or gene segments, that code for the bacterial chloramphenicol acetyltransferase, the bacterial gene conferring resistance against hygromycin, and the ORF E7 of the human papillomavirus type 18 into these vectors.

bacterial chloramphenicol acetyltransferase


Input: By contrast, their basal adrenal androgen levels were significantly decreased compared to those in normal subjects on both the day on and the day off prednisone (P less than 0. 05).


Input: Identification of p40x-responsive regulatory sequences within the human T-cell leukemia virus type I long terminal repeat.


Input: During pentobarbital anesthesia, the basal VO2 was 5. 26 ml/kg/min and was increased by epinephrine in a dose dependent manner at plasma concentrations between 3. 9 ng/ml (VO2 = 5. 68 ml/kg/min) and 36. 5 ng/ml (VO2 = 6. 47 ml/kg/min).


Input: Oligonucleotide-directed mutagenesis was used to create an NdeI restriction site at the natural ATG of the yeast R.

NdeI restriction site


Input: ACTH release is transiently suppressed in some children after exogenous ACTH treatment.

ACTH

ACTH


Input: We previously showed that the upstream promoter element of the yeast RP39A gene consists of these identical sequence motifs.

yeast RP39A gene


Input: These data suggest that mammalian erythroid alpha-spectrin evolved by duplication and rapid divergence from an ancestral alpha-fodrin-like gene.

alpha-spectrin

alpha-fodrin-like gene


Input: One group of six cDNA clones was derived from a 2. 9-kilobase early transcript encoded by the IR2 repeat element and showed restriction site polymorphism for the enzyme SmaI.

enzyme SmaI


Input: Combined immunochemotherapy with cyclophosphamide plus BCG gave a better enhancement of the antitumor effect of the cytostatic than that of the combination of methotrexate plus BCG and cyclophosphamide plus levamisole.


Input: Indeed, A-MuLV pseudotyped with some viruses, such as the Moloney MuLV, has been shown to be highly lymphogenic, whereas A-MuLV pseudotyped with other viruses, such as the BALB/c endogenous N-tropic MuLV, has been shown to be devoid of lymphogenic potential (N.


Input: The presence of circulating platelet aggregates and elevated levels of fibrinopeptide A (a cleavage product of fibrin) suggests that platelet activation and fibrin deposition may play a role in the pathogenesis of this disorder.

fibrinopeptide A

fibrin

fibrin


Input: In general, the values obtained by the two methods were in agreement for each species of epidermal growth factor and followed the order: wild type greater than Glu24----Gly greater than Asp27----Gly much greater than Pro7----Thr greater than Tyr29----Gly greater than Leu47----His.

epidermal growth factor


Input: It is concluded that suppression of elevated prolactin levels in progressive metastatic breast cancer patients is not effective in restoring tumor sensitivity to chemotherapy.

prolactin


Input: We report a prevalence study of the best visual acuity in the affected eye of 100 selected patients with herpetic keratitis seen during a two-year period.


Input: We also found an eIF-4A intronless retroposon which, when compared to the cDNA, contains a single nucleotide difference.


Input: After infection of 293 cells (which provide complementary E1a-E1b functions), both viruses directed equal amounts of P/C-specific mRNA transcription.

P/C-specific mRNA


Input: This observation cannot be explained by the scanning model for ribosomal initiation and suggests that ribosomes may be binding directly at an internal mRNA site at or near the initiator AUG codon for the C protein.

C protein


Input: In view of these results, simultaneous pancreas-kidney transplantation appears to be the treatment of choice for Type I diabetic patients.


Input: This makes these compounds attractive as vehicles for these and other gases in-vivo and in-vitro.


Input: DNA sequencing of the DPM1 gene revealed an open reading frame of 801 bases.

DPM1 gene


Input: The relationship between primary malignant lymphoma of the thyroid and chronic thyroiditis is discussed.


Input: Administration of anticoagulants, i. e., heparin, prostaglandin E1 and ticlopidine seems to be effective in alleviating symptoms and might prevent further deterioration.


Input: Mutational analysis of the L1 binding site of 23S rRNA in Escherichia coli.

L1 binding site

23S rRNA in Escherichia coli


Input: Animals may be immunized by oral vaccination, but natural mechanisms that also can terminate outbreaks are discussed.


Input: Prostacyclin formation, reflected by the excretion rate of its stable metabolite 6-keto-prostaglandin F1 alpha, was measured by means of radioimmunoassay in 4-hour urine specimens obtained during a smoking-free period and after participants had inhaled smoke from four high-nicotine cigarettes.


Input: However, excretion of 6-keto-prostaglandin F1 alpha was further reduced in the smokers who used oral contraceptives (133 +/-20 to 86 +/-9 ng/gm of creatinine, p less than 0. 05).


Input: The in vitro activity of mecillinam and amoxicillin/clavulanic acid against Escherichia coli strains producing beta-lactamases of the TEM-1, Oxa-1 and chromosomal type were studied using the broth and agar dilution technique.

beta-lactamases


Input: GCN4 encodes a transcriptional activator of amino acid biosynthetic genes in Saccharomyces cerevisiae.


Input: These results imply that the GCN3 product can promote either repression or activation of GCN4 expression depending on amino acid availability.

GCN3 product


Input: The efficacy of these immunosuppressive drugs is clinical proven.


Input: The amino acid sequence of the S. aureus peptide carrying the phosphoryl group was found to be Gln-Val-Val-Ser-Thr-Phe-Met-Gly-Asn-Gly-Leu-Ala-Ile-Pro-His-Gly-Thr-Asp-Asp.


Input: These mutations alter two regions of GAL4 protein: the DNA binding domain, and the transcription activation domain.

GAL4 protein


Input: The results indicated that two genes (citA and citB) have separate promoters, and the location of the promoter for the citB gene in the Tn3411 nucleotide sequence was different from that in pMS185.

citA

citB

citB gene


Input: The rci gene was fused with lacZ and its gene product was identified by Western blot analysis.

rci gene

lacZ


Input: Structure and regulation of a nuclear gene in Saccharomyces cerevisiae that specifies MRP13, a protein of the small subunit of the mitochondrial ribosome.


Input: After a survey of the anatomical and physiological basis of operative treatment of behaviour disorders by stereotactic lesions in the amygdala and the posterior medial hypothalamus the author describes his own experiences with 603 operations for control of conservatively untreatable aggressiveness.


Input: Although large epidemiologic studies are best able to identify the relative contributions of specific risk factors while controlling for other risk factors, new studies need to focus on important unresolved questions.


Input: The amino acid sequences of the yeast and mammalian mitochondrial targeting sequences are similar but less related than the mature polypeptides.


Input: During insulin infusion, a 20% dextrose solution was infused by a Biostator in order to maintain the patient' s glycemia at 90 mg/dl.

insulin


Input: Amounts of glucose infused during the last 20 min of each 2 hour insulin infusion were (at 1 and 10 m/kg/min respectively): before treatment (K + = 2. 7 mmol/l): 2. 4 and 8. 4 mg/kg/min; after spironolactone (K + = 3. 9 mmol/l): 3. 3 and 15. 4 mg/kg/min; after indomethacine (K + = 3. 7 mmol/l): 5 and 19 mg/kg/min after stopping drugs (K + = 2. 9 mmol/l): 2. 5 and 5. 3 mg/kg/min.

insulin


Input: Mycobacterium avium-intracellulare complex infections in the acquired immunodeficiency syndrome.


Input: Recurrence of oxalate deposition in a renal transplant during ciclosporin A therapy.


Input: The bile acid sequestrants (cholestyramine and colestipol), nicotinic acid, fenofibrate and inhibitors of hydroxymethylglutaryl coenzyme A (HMG CoA) reductase (e. g. lovastatin or simvastatin) are the most effective drugs for use in patients with primary hypercholesterolaemia; these agents reduce plasma concentrations of total and LDL-cholesterol by 15 to 45%.

hydroxymethylglutaryl coenzyme A (HMG CoA) reductase

LDL-cholesterol


Input: Finally, the pathophysiological aspects of urinary acidification are discussed, focusing on renal tubular acidosis models (induced by maleate and amphotericin B treatment) and their cellular mechanisms, as well as the role of adrenal steroids in urinary acidification.


Input: Analysis in 3 groups of patients suffering from simple acute and pernicious malarial flare-ups


Input: Statement on the development of guidelines for the prevention of AIDS transmission in the workplace.


Input: Modifications of the involuntary postcontraction in diseased people.


Input: Cocaine-treated rats acquired a preference for cocaine-associated contextual stimuli (CS) relative to saline-injected control rats.


Input: Under these schedules, a reinforced response run consisted of responding between eight and 12 times on one response key (work key) and then responding once on a second response key (reinforced key).


Input: Intravenous glucose tolerance tests were performed before operation, before starting CyA and after 3 weeks.


Input: The effects of glutaraldehyde on dimensions and ultrastructure of microvascular beds in rat mesentery were studied in two kinds of experiment, administering the fixative by intra-arterial perfusion at a pressure of 80 mm Hg and by superfusion of the exteriorized mesenteric membrane.


Input: This gave rise to RNA molecules with 3'-untranslated regions of roughly 375, 655, and 945 base pairs.


Input: Also, the BALB/c gene contains a single substitution in a conserved octamer sequence approximately equal to 100 nucleotides upstream of the coding region, which could affect its expression.

BALB/c gene


Input: Our data suggest that it may be possible to individualize hCG administration at midcycle by determining the number of follicles greater than 1 cm by ultrasound on cycle day 12 or 13 and giving hCG when serum E2 levels reach 1100 to 1200 pmol/l per follicle.

hCG

hCG


Input: Within Stage IA, 141 patients had well differentiated tumor (G1), 20 had moderately well differentiated tumor (G2), and 12 patients had poorly differentiated (G3).


Input: Mechanism of the t (14; 18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners.


Input: After age 30, mean hemoglobin levels for men gradually declined, while those in women rose, so that the sex difference diminished after 60 years of age.

hemoglobin


Input: Ritanserin is a new substance with highly selective blocking activity on S2 receptors for 5-HT in the central nervous system.

S2 receptors


Input: Ethylene glycol and diethylene glycol were each administered once weekly subcutaneously to groups of 100 female NMRI mice at 3 dosages (30; 10 und 3 mg single dose per mouse).


Input: Research on ethylene glycol and diethylene glycol for carcinogenic effects


Input: The results suggest that the greater estrogenic influence associated with the ethinyl estradiol-containing OC resulted in inhibition of coronary artery atherosclerosis despite a pronounced progestin-induced lowering of plasma HDL cholesterol concentration and, further, that hormonal balance may have a marked influence on the relationship between plasma lipids and atherogenesis.

HDL cholesterol


Input: During BH the ventilator was disconnected and a bias flow of 50% O2 at 4-5 l/min was delivered through the side ports of a small catheter whose tip was positioned 1 cm cephalad of the carina.


Input: Comparison of beta 2-microglobulin removal using the same polysulphone membrane for haemodialysis and haemofiltration shows that beta 2-microglobulin is more effectively removed by convection than by diffusion when both treatment modes are matched for blood flow and urea clearance.

beta 2-microglobulin

beta 2-microglobulin


Input: 40. 3 +/-10. 1 mg/l (SD) vs 31. 2 +/-8. 0, P less than 0. 01). beta 2m was not significantly higher in patients with bone cysts (37. 7 +/-11. 4 mg/l vs 37. 0 +/-10. 0), but median duration of dialysis was significantly (P less than 0. 01) longer in patients with bone cysts (90 vs 57 months). beta 2m was lower in patients maintained on dialysis for less than 1 year and whose residual urine volume was greater than 0. 1 litre per day.

beta 2m

beta 2m


Input: The mean percentage of linoleic acid in the triglycerides of the subcutaneous adipose tissue (PLASAT) of these subjects was substantially higher than that in a similar group examined in 1975-1976.


Input: In overdoses up to 2 g fluvoxamine no lasting toxic effects were observed.


Input: It is concluded that the plasma prolactin response to 12. 5 micrograms i. v.

plasma prolactin


Input: The remaining six patients had slightly decreased (n = 3) or normal (n = 3) seminal parameters.


Input: In addition, a wild-type strain containing a temperature-sensitive threonyl-tRNA synthetase mutation showed increased thr operon expression at the non-permissive temperature, whereas none of the mutants showed any change.

temperature-sensitive threonyl-tRNA synthetase mutation

thr operon


Input: Significant treatment-related problems appeared during the second decade in 5 patients, including one chest wall sarcoma; all of these patients had received at least 60 Gy to breast and regional nodal areas.


Input: Of 7 patients treated with cyclophosphamide, hexamethylmelamine, adriamycin and cisplatin (CHAP-5), 6 had measurable disease, of whom 5 yielded a response (2 complete responses for 19 + and 40 months and 3 partial responses for 4, 7 and 8 months).


Input: Isolation and characterization of a vinculin cDNA from chick-embryo fibroblasts.

vinculin cDNA from chick-embryo fibroblasts


Input: A complementary study, showing a good agreement between surface and oesophageal EMGd seems to confirm that surface EMGd is a useful and promising tool for clinical investigation.


Input: No differences in fixation quality were observed between cochleas fixed by intravascular perfusion and cochleas fixed by intralabyrinthine perfusion.


Input: The DNA sequence encodes a protein of 1520 amino acids with sequence homology to the human c-abl proto-oncogene product, beginning at the amino terminus and extending 656 amino acids through the region essential for tyrosine kinase activity.

human c-abl proto-oncogene product

tyrosine kinase


Input: The requirement of different essential fatty acids in patients with total parenteral nutrition after heavy injury is of special interest with respect to the development and prognosis of shock, sepsis or adult respiratory distress syndrome.


Input: The Drosophila melanogaster Gart gene encodes three enzymatic activities in the pathway for purine de novo synthesis.

Drosophila melanogaster Gart gene


Input: The role of neuroplasticity in the response to drugs.


Input: Biol.


Input: The heart rate, respiratory rate, arterial O2 and systemic vascular resistance were not significantly altered.


Input: Human rIL-3 expressed in COS7 cells has multipotential CSF activity in semisolid cultures of bone marrow cells, and selectively induced the proliferation of My-10 + marrow or cord blood cells in liquid cultures.

Human rIL-3

CSF


Input: In 14 patients whose PaCO2 was greater than or equal to 39 torr (range 39 to 58 torr) and clinical asthma score was 6 or greater, PaCO2 decreased a mean of 11. 7 torr during a mean of 8. 1 hours.


Input: A randomized, prospective study was conducted to compare ovarian stimulation with human menopausal gonadotropin (hMG) and human follicle-stimulating hormone (hFSH) in an in vitro fertilization and embryo transfer (IVF-ET) program.

human menopausal gonadotropin

hMG

human follicle-stimulating hormone

hFSH


Input: Our findings suggest that the mtr product causes both transcription attenuation and inhibition of translation of trpE mRNA.

mtr product

trpE mRNA


Input: Apropos of a case


Input: A prostaglandin analogue given in early pregnancy and human chorionic gonadotropin given near the end of the ensuing follicular phase were used for controlling the reproductive cycle, timing oocyte collection, and synchronizing the cycles of oocyte donors and embryo recipients.

human chorionic gonadotropin


Input: The nucleolin gene extends over 9000 base-pairs and is split into 14 exons that encode the 706 amino acid residues of the protein.

nucleolin gene


Input: Although L-threo-dihydroxyphenylserine (DOPS), an artificial norepinephrine (NE) precursor, did not change immobility in intact mice, DOPS significantly reduced immobility in mice pretreated with the selective NE neurotoxin DSP4.


Input: Substantial amounts of liposomal ampicillin were recovered from isolated Kupffer cells, the target cells of L. monocytogenes after intravenous inoculation.


Input: This suggested that delta 6 and delta 5 desaturation activities are normal in these conditions with this C18: 2w6 supply.


Input: Here we report the complete 6-kilobase cDNA sequence coding for a chain of 1775 amino acids, as well as the genomic structure.


Input: HDL-cholesterol (+ 6%, P less than. 01) and apolipoprotein A-I (+ 6%, P less than. 01) concentrations increased significantly only in the young.

HDL-cholesterol

apolipoprotein A-I


Input: The Euglena ribosomal protein gene cluster resembles the S-10 ribosomal protein operon of Escherichia coli in gene organization and follows the exact linear order of the analogous genes in the tobacco and liverwort chloroplast genomes.

Euglena ribosomal protein gene cluster

S-10 ribosomal protein operon of Escherichia coli


Input: The distribution of the sites of recombinational resolution is inversely correlated with that of the gradient of sequence divergence, with only approximately 7% of the X recombinants resolved within the 3' third of the X blocks where two diverged Alu family repeats reside.

Alu


Input: The nucleotide sequence of the region upstream from M. voltae ORFtrpA was determined and revealed the presence of an ORF of 1227 nucleotides (ORFtrpB) encoding a 409 amino acid polypeptide of mol. wt.

M. voltae ORFtrpA

ORFtrpB


Input: Of 49 receptors which fired in phase with ventilation, 13 behaved like mammalian rapidly adapting pulmonary stretch receptors, 19 like mammalian slowly adapting pulmonary stretch receptors (PSR), and 17 like avian intrapulmonary CO2-sensitive chemoreceptors (IPC).


Input: Symptomatic hyperventilators had a larger number of sighs and abnormally wide fluctuations in baseline for inspiratory time, expiratory time, and PETCO2.


Input: In the IA task, post-training intraperitoneal injections of picrotoxin and bicuculline induced a dose-dependent enhancement of retention measured 24 h after the training, while retention was not affected by bicuculline methiodide (a GABA receptor antagonist that does not readily cross the blood-brain barrier).

GABA receptor


Input: Clinical research of non-A, non-B post-transfusion hepatitis


Input: It is suggested that the use of endogenous creatinine clearance to estimate the glomerular filtration rate (GFR) requires caution and the recognition of the limitations of the method, and that simpler techniques (serum creatinine or estimated endogenous creatinine clearance) are preferable in routine practice.


Input: The protein mixtures of sesame flour and soybean flour were well accepted.


Input: The 5' end of the coding region was located precisely by comparing the deduced amino acid sequence to the actual N-terminal amino acid sequence of IHF.

IHF


Input: A protein footprint also was identified for a GC box element at nucleotides-59 to-45.


Input: Insulin-like growth factor II (IGFII) is a mitogenic polypeptide, the mRNAs of which are present in multiple forms, despite derivation from a single gene.

Insulin-like growth factor II

IGFII


Input: The central visual fields of 2165 normal and 106 glaucoma eyes were measured using a threshold related suprathreshold strategy.


Input: Effect of chronic undernutrition on susceptibility to cold stress in young adult and aged rats.


Input: This effect and the fact that all three doses were toxic to the dams dictated that a second experiment be carried out at lower doses.


Input: The CHARGE association is a collection of multisystem congenital anomalies including choanal atresia.


Input: Esophageal brush cytological screening was undertaken and blood concentrations of micronutrients (vitamin A, E, B12, folic acid and methionine) determined from adults at risk for esophageal carcinoma (EC) in Transkei and Ciskei, Southern Africa.


Input: Aviators from the Light Attack Wing, Pacific were surveyed and the results were categorized by aircraft type.


Input: Evaluation of human and bovine modified-hemoglobin solution as oxygen-carrying fluid for blood volume replacement.

hemoglobin


Input: Delayed gallbladder visualization and reduction in ejection fraction were sensitive but nonspecific indicators of biliary disease.


Input: 26 micrograms PAF or placebo was sprayed into each nasal cavity 8 h and 1 h before a nasal allergen challenge.

PAF


Input: Sci.


Input: Chem.


Input: Sequential MR examinations of the nasal cavity and paranasal sinuses were performed within a 6-8 h period in five normal volunteers.


Input: Comparison was made with other neuroradiological imaging modalities including CT, myelography, CT ventriculography, and CT myelocisternography.


Input: The feed given to young broiler chickens was contaminated artificially with Salmonella kedougou, a serotype associated with both subclinical infections in commercially reared chickens and food poisoning in humans.


Input: A poor correlation was found between a mildly-atypical (inflammatory) cytological result (class 2) and a benign histological diagnosis: 48% of class-2 smears were diagnosed histologically as dysplasia or worse.


Input: Change in plasma cystyl aminopeptidase (oxytocinase) between 30-34 weeks' gestation as a predictor of pregnancy-induced hypertension.

plasma cystyl aminopeptidase

oxytocinase


Input: The test for alpha-naphthyl esterase and quantitation of macrophages (absolute number) per infiltration area unit adjacent to the abscess suggest a direct correlation between the absolute number of macrophages and the width of the capsule.

alpha-naphthyl esterase


Input: Determined as migration differentials, chemotactic and chemokinetic responsiveness tended to be higher in the neutropenic group.


Input: The deduced 96-residue amino acid coding sequence of the murine HMG-I (Y) cDNA is very similar to the reported amino acid sequence of human HMG-I, except that it lacks 11 internal amino acids reported in the human protein.

HMG-I (Y)

HMG-I


Input: Interpersonal style differences among drug abusers were explored using Ryan' s (1977) typological system of FIRO-B interpretation.


Input: Statement of the American Academy of Implant Dentistry.


Input: Sera from euthyroid post-menopausal or pregnant women yielded TSH levels within the normal range.

TSH


Input: No UOxase mRNA was detected in 11 nonhepatic tissues of rat, suggesting tissue specificity of expression of this UOxase gene.

UOxase mRNA

UOxase gene


Input: The platelet adhesion rate on these layers were tested concerning the valuation of the haemocompatibility of the basic-polymers polyurethane (PUR), polyvinylchloride (PVC), and polystyrene (PS) in two different worked test chambers.


Input: In a 112-d feedlot trial, 105 heifers were assigned to light, medium and heavy weight blocks on five treatments: dietary MGA (. 5 mg. hd-1. d-1), control (no MGA) or DEPO-MGA on d 1 at. 5, 1. 0 or 1. 5 ml/hd (30, 60 or 90 mg MGA/hd, respectively).


Input: Existence and uniqueness of solutions of the appropriate boundary value problems are established, in the case of small permeability coefficients and transport rates, or large diffusion coefficients and small resistance to flow constants.


Input: There were gene clusters encoding photosynthesis components such as the psbB-psbH-petB-petD and the psbE-psbF clusters.

psbB

psbH

petB

petD


Input: The partial sequence of the 62-kDa nuclear pore glycoprotein shows little similarity to other characterized proteins and elucidates structural features of a member of the family of nuclear pore glycoproteins.

62-kDa nuclear pore glycoprotein

nuclear pore glycoproteins


Input: Seventy-two hours after administration of vitamin K1, plasma concentrations of the vitamin were not different from normal.


Input: The glomerular filtration rate did not change but lithium clearance fell by 30%.


Input: The pathogenesis of Dupuytren' s contracture


Input: An ELISA procedure was developed for monitoring the specific IgE response in dogs to Dirofilaria immitis infection.

IgE


Input: Fifty min after release from stress, increases in plasma corticosterone levels induced by stress recovered in the biting group but remained high in the non-biting group.


Input: The only isolate of Aeromonas hydrophila produced cytotoxic enterotoxin and was invasive.


Input: The incidence of early neonatal convulsions for inborn babies was 3. 0/1000 live births.


Input: Of the 43 infants with a (probable) loss 18 were examined again at 3 months corrected age.


Input: Variety of cows and sires according to types of dermatoglyphics (patterns) of the nose-labial mirror of cattle


Input: Although not consistently identified in all samples, secondary Academic, Personal Responsibility, and Community/Vocational dimensions were also identified.


Input: Recovery was characterized by rapid improvement such that all measured parameters normalized by 1 week, except for cross-sectional cardiac area which remained dilated up to 4 weeks (14 +/-3 cm2, p less than 0. 05 versus control). (ABSTRACT TRUNCATED AT 250 WORDS)


Input: Not even extensive pancreatic resection could prevent pancreatic remnant infection.


Input: It has been calculated that 600, 000 new cases of lung cancer occur worldwide every year, most of them due to smoking.


Input: Incorporation of 0. 1 or 0. 2 M sodium dihydrogen phosphate in the sugar solutions resulted in a decrease in the shelf-life of diltiazem.


Input: None had a past history of opportunistic infections; neither did any have lymphopenia.


Input: Increasing the phosphorus content of the diet improved the reabsorption of calcium and magnesium.


Input: Post-transcriptional regulation of ribosomal protein gene expression during development in Dictyostelium discoideum.

ribosomal protein gene


Input: The increase in amplitudes of the b-wave during the adaptation period was more prominent in lead-exposed subjects than in controls.


Input: Possible factors for the development of psychotic symptomatology during group activities and the role of group dynamics acting as stress factors precipitating functional psychoses, especially bipolar manifestations, are discussed.


Input: Baseline measurements of forced expiratory volume in 1 s (FEV1), specific airway conductance (SGaw) and the provocative dose of carbachol causing a 35% reduction in SGaw (PD35), and a 20% reduction in FEV1 (PD20) were established on entry while each subject was still smoking.


Input: Many children with BGC are delayed in their development, but calcifications are not directly related to specific forms of neurologic dysfunction.


Input: R-wave voltage in the right precordial leads in anthracycline cardiomyopathy: a clinical study.


Input: The results indicate that the pooling requirements are task dependent.


Input: These results indicate that CSFHU can increase neutrophil counts by increasing the number and maturity of the marrow neutrophil precursors in some types of childhood chronic neutropenia.

CSFHU


Input: The purposes of this study were 1) to examine the effect of high intensity, low frequency transcutaneous electrical nerve stimulation at auricular acupuncture points on experimental pain threshold measured at the wrist and 2) to determine the changes in effect over time.


Input: In the infected neonates serum alpha-amylase value, as determined by the blue starch method, was only 40% that of healthy controls; the mean value of 175. 1 +/-64. 9 IU/l for healthy neonates was significantly higher (p less than 0. 0010) than the value of 82. 8 +/-44. 4 IU/l for the infected neonates.

alpha-amylase


Input: Records of 31 children with AIDS or AIDS-related complex admitted to the pediatric intensive care unit for acute respiratory failure throughout a 46-month period were reviewed.


Input: SPECT is an important aid in the diagnosis of AIDS dementia complex and contributes to the understanding of the pathophysiological mechanisms of this disorder.


Input: We were interested in studying the relationship between the circadian rhythm in body temperature and 24-h variations in plasma concentrations of iron, zinc, circulating leukocyte counts, and plasma interleukin 1 (IL-1) activity.

interleukin 1


Input: The murine MHC class I genes, H-2Dq and H-2Lq, are strikingly homologous to each other, H-2Ld, and two genes reported to encode tumor-specific antigens.

murine MHC class I genes


Input: The active derivatives of the present series were also tested for their analgesic activity against aconitine-induced writhing in albino mice and ulcerogenic activity in albino rats.


Input: In untreated mice, bactericidal activity of peritoneal macrophages decreased from one day to 3 days after ip injection of killed L. monocytogenes.


Input: Among a population of 18, 175 children below 7 years of age in medium sized towns and rural areas in south-western Germany 552 (3. 03%) cases of croup were registered during a 12 months period in 1984-85 by their physicians.


Input: We concluded that Ga-fbg scintigraphy is a very simple method and sufficiently useful for detecting active left ventricular thrombi and for monitoring the effect of anticoagulant therapy.


Input: In vitro assessment of the biocompatibility of dental materials--the millipore filter method.


Input: Hypomagnesemia was due to magnesium wasting by the kidney.


Input: Dentalplaque was controlled by the oral higienic index of the whole dentition daily, after staining with 1 per cent alkaline fuxin.


Input: GRFI bound to sequences at the negative regulatory elements (silencers) of the silent mating type loci HML E and HMR E and to the upstream activating sequence (UAS) required for transcription of the MAT alpha genes.

GRFI

silent mating type loci HML E

HMR E

MAT alpha genes


Input: The effects of these mutations on RNA polymerase II activity were assayed by measuring the ability of mutant genes to confer alpha-amanitin resistance after transfection of susceptible rodent cells.

RNA polymerase II

alpha-amanitin


Input: We report the use of a new technetium-99m-albumin colloid white blood cell (TAC-WBC) scan in the evaluation of appendicitis.

albumin


Input: In one of these tumors the observed rearrangement was not due to the insertion of an intact MoMuLV provirus.


Input: The indications for its use include every primary and secondary rhinoplasty candidate unless tip grafts are going to be under tension or if the deformity is minor.


Input: Mutations at the suf12 locus were isolated in Saccharomyces cerevisiae as extragenic suppressors of + 1 frameshift mutations in glycine (GGX) and proline (CCX) codons, as well as UGA and UAG nonsense mutations.

suf12 locus


Input: The behavior of suf12-null/SUF12 + heterozygotes indicates that suf12 is co-dominantly expressed and suggests that suf12 allele-specific suppression may result from functionally distinct mutant proteins rather than variation in residual wild-type SUF12 + activity.

suf12-null/SUF12 + heterozygotes

wild-type SUF12 +


Input: Antituberculosis agents.


Input: The putative immunity protein was detected among the [35S] methionine-labelled proteins produced by minicells carrying cni cloned under lac promoter control, and when the gene was subcloned into expression vectors under the control of a bacteriophage T7 promoter.

cni

lac promoter


Input: Antibodies made against fusion protein produced by the DP1A clone reacted specifically with DP-I and-II on immunoblots.

DP-I and-II


Input: Finally, over a similar range of QO2, oxygen extraction was greater in patients with ARDS compared to patients with non-ARDS respiratory failure (r =-0. 67 and slope =-0. 62 vs r =-0. 45 and slope =-0. 35; p less than 0. 05).


Input: Stable patients have mucous hypersecretion and little evidence of acute inflammation.


Input: Hyperprolactinaemia, moderate hypogonadism, infraclinical neuropathies, arterial stenoses and moderate venous leakages seem to play a partial role of organic starter or cofactor, the sexual consequences of which are amplified by psychological factors, partly secondary to the initial sexual failures.


Input: Yang and H.


Input: Secretory function of the prostate gland.


Input: Chronic endotoxemia appears to be associated with an elevated pulmonary microvascular permeability and a tendency toward a hyperdynamic circulation but with an appreciable degree of refractoriness associated with regional hemodynamics and eicosanoid biosynthesis.


Input: In contrast, we observed high concentrations in 29 of 75 patients with tumors of the central nervous system, especially in meningioma (6/9), glioblastoma (9/23), and neurinoma (5/5).


Input: Diet and atopic eczema.


Input: Time delay effects on the tensile bond strength developed by the Silicoater.


Input: The future of research with interferon may be divided into three areas: Efforts must be made to determine how best to translate the in vitro synergy into clinically meaningful terms; in order to exploit the fullest potential of IFN, research is moving toward using this agent earlier in disease either as an adjuvant after tumor debulking or after initial diagnosis; the medical community must rethink the natural history of some diseases, because the fullest potential of the biologic agents will most likely manifest itself when these agents are used together.

interferon

IFN


Input: Six healthy male subjects received single oral doses of regular release (RR) quinidine sulfate, sustained release (SR) quinidine bisulfate and the same dose of the SR product with food (SR-F).


Input: This report expands on previous work with interferon alfa-2b (Intron A; Schering-Plough) in the treatment of hairy cell leukemia (HCL).

interferon alfa-2b (Intron A; Schering-Plough)


Input: Oxygen delivery and base excess decreased significantly and four pigs died.


Input: Clinical chemistry.


Input: Revascularization after anterior maxillary and mandibular osteotomy


Input: Static orthoses for the management of microstomia.


Input: The intrapancreatic spread of the carcinoma correlated with portal invasion of carcinoma, hardness of the body and tail, obstruction of main pancreatic duct and irregular pancreaticogram.


Input: Lysosomal enzymes that degrade cartilage are released.


Input: Contrary to the observation made with other S. pombe genes transcribed in the budding yeast, the heterologous actin gene transcript is initiated 39 nucleotides upstream of the initiation start site used in the homologous yeast.

actin gene transcript


Input: A multicentre study involving 9 Italian institutions was carried out to compare the efficacy and safety of ranitidine 150 mg b. i. d. and ranitidine 300 mg nocte in the treatment of reflux oesophagitis.


Input: Monotherapy with ceftazidime was clinically and bacteriologically as effective as a combination therapy with cefazolin and tobramycin.


Input: The N3 wave of the SSEP' s, which has been found to correlate best with neurological recovery, returned to 65% +/-48% of the preischemia amplitude in the insulin-treated animals, compared to 40% +/-34% in the fasted group and 26% +/-24% in the control animals.

insulin


Input: Proctoscopy and roentgenographic studies may be an important part of evaluation, especially in patients who present with perianal suppuration, masses, or anal fissures.


Input: In the control group the histological picture resembled osteoarthritis.


Input: In contrast to this mRNA, 90% of alpha and beta actin mRNAs were translated in both myoblasts and myotubes.

alpha and beta actin mRNAs


Input: If this is unavailable, then Supramid has a proven record for good tissue compatibility and resistance to infection.


Input: The size of the group allocated to the good compliance category by the use of the digoxin marker was equivalent in size to a group of patients who had returned less than 15% of their prescribed dose or reported a deviation of less than 6% from their prescription.


Input: Bullous keratopathy was usually aphakic in origin in 1982, but after 1983 pseudophakic bullous keratopathy (PBK) was the most common cause of bullous keratopathy.


Input: The ultrastructural findings, as well as the urinary C-peptide excretion, confirmed that the glycemic effects should not be thought to be due to a direct action of the drugs used on the endocrine pancreas.

C-peptide


Input: In vitro antimalarial activity of neem (Azadirachta indica A.


Input: " In vitro " study of dentin adhesion to adhesives made from urethane molecules with free groups of isocyanate


Input: There is a cysteine clustering region in an N-terminal region of the c-raf (-1) product deduced from the nucleotide sequence, and this cysteine clustering region was found to be highly homologous to that present in an N-terminal region of protein kinase C, although, in the latter cysteine clusters are present in duplicate.

c-raf (-1) product

protein kinase C


Input: Hand-held, continuous-wave Doppler probes, coupled with sound spectral analysis, can successfully predict carotid artery stenosis.


Input: The German Society of Pediatric Oncology in 1981 initiated the Cooperative Ewing' s Sarcoma Study (CESS 81) using a four-drug combination of chemotherapy prior to definitive local control with surgery and/or radiation.


Input: The program has been written in a generic BASIC in order to make the procedure user-friendly.


Input: Since high levels of immunoglobulin G were demonstrated against the surface of the NVS after immunization, passive transfer experiments were initiated.

immunoglobulin G


Input: A study was conducted of a human male who had inhaled a mixture of 241Am and Pu.


Input: An analytic method for comparative parameter weighting in magnetic resonance (MR) imaging has been developed using the concept of " fractional sensitivity. " This new approach results in easily calculated indexes for T1, T2, and hydrogen weighting.


Input: Fifty-four patients were divided into groups according to their clinical presentation; seven asymptomatic volunteers, 20 patients with duodenal-gastric reflux gastropathy (DRG), 16 patients with recurrent ulcers of the duodenal bulb (RUD), and 11 patients with Moynihan' s disease.


Input: No previous studies have determined the pharmaco-dynamics of intravenous procainamide when administered in a dose of 15 mg/kg and at a rate of 50 mg/min, as is common practice during electropharmacologic testing.


Input: High concentrations of tumor-associated trypsin inhibitor in hemodialyzed patients.

trypsin


Input: In the chicken liver, levels of chicken MT mRNA were rapidly induced by metals (Cd2 +, Zn2 +, Cu2 +), glucocorticoids and lipopolysaccharide.

chicken MT mRNA


Input: With histology and Evans blue injections, blood-brain barrier alterations were seen as early as 4 days after a dose of 50 Gy.


Input: Dosimetric estimates for these organs were 2. 3 +/-1. 1 and 2. 3 +/-1. 4 rad (. 02 +/-. 01 Gy), respectively, with a whole-body estimate of 0. 28 rad (. 003 Gy).


Input: A significant association between a family history and a higher urinary pH was observed among the female calcium stone patients.


Input: New technologies in diagnosis and classification of malignancy.


Input: Thus the present data also suggest that BP and HR measurements are influenced not only by state-dependent factors but also by at least three different factors that are each independent of the state: one leads to BP and HR values that are influenced by the cycle the animal is in and the other two influence, respectively, the ranking of the individual' s BP and HR levels within the population.


Input: The correlation between PaCO2 and PtcO2 in RDS was insufficient to make clinical judgement.


Input: Since 1967 at the times of their biennial ABCC/RERF radiological examinations, all Adult Health Study (AHS) subjects have been interviewed to determine the exposures to medical x-rays they experienced in institutions other than RERF in order to estimate the numbers of examinations and corresponding doses which they received.


Input: One millimolar ouabain completely inhibited net HCO3-secretion.


Input: There are regions with long runs of up to 45% C or 35% G residues.


Input: The same rhythmic structure enables a prediction to be made concerning when vowels of stressed syllables will be auditorily perceived.


Input: Vocal cord abduction rehabilitation by nervous selective anastomosis.


Input: UK' s biotechnology lacking specialists.


Input: Distant spread was found in 46 patients (34%), 42 of whom had serum Tg greater than 10 micrograms/l.

Tg


Input: The glomerular filtration rate and effective renal plasma flow were determined by a standard clearance method, employing continuous infusion of inulin and para-aminohippuric acid.


Input: After the meal containing potato, plasma glucose levels rose sharply, peaked at 30-45 min and fell below initial levels 2 to 3 h later.


Input: The relations among various negative emotional and behavioral characteristics (e. g., aggression, anxiety, undercompliance, depressive mood) and adjustment were examined through use of data from the 31-year-old New York Longitudinal Study.


Input: To evaluate the effect of altitude on adolescent growth and development, three groups of healthy, well-nourished youth of similar socioeconomic status and ethnic grouping who resided at sea level (n = 1262 subjects), mid-altitude (n = 1743 subjects), and high altitude (n = 1137 subjects) were studied.


Input: Because the CAP measures variables predictive of abusive behavior, a substantial relationship was expected between the CAP and the MHI Loss of Behavioral/Emotional Control scale.


Input: We have improved our system for nuclear contour digitization and determined its theoretical limitations by digitizing standardized objects.


Input: Such a change may involve increased mammary utilization of pre-formed long-chain fatty acid and increased metabolism of glucose via glycolysis.


Input: The skin site, 6-cm-distal and-proximal subcutaneous segments of the catheter, exudates, and blood were cultured.


Input: Because of its great reliability, conventional arteriography occupies a place of choice among the medical imaging techniques.


Input: Rapid detection of radioisotopically contaminated test serum before radioassay of vitamin B12.


Input: The former group did excrete less dry fecal material compared to both other groups.


Input: Electronic data processing (EDP) latex immunoassay using anti-human seminal acid phosphatase (anti-HSAP) immune serum was applied for the species and organ identification of human seminal stains.

anti-human seminal acid phosphatase

anti-HSAP


Input: The maximum deflections of phase IV for Ar and N2 from extrapolated phase III slopes were smaller in the prone position, suggesting more uniform tracer gas concentrations across the lungs.


Input: Recent developments in drugs antagonistic to factors causing peptic ulcer--clinical efficacy and problems; gastrin receptor blockaders

gastrin receptor


Input: Static magnetic fields affect the diffusion of biological particles in solutions through the Lorentz force and Maxwell stress.


Input: Psychological disturbance was greater in the high life stress group as indicated by significant elevations on the global severity index of the Symptom Checklist-90 and elevations on somatization, obsessive compulsive, interpersonal sensitivity, depression, anxiety and psychoticism subscales.


Input: Chronic administration of sodium cyanate decreases O2 extraction ratio in dogs.


Input: Nucleotide sequencing indicates that this E1 alpha cDNA clone is 1821 base pairs (bp) in length with an open reading frame of 1365 bp and a 3'-untranslated region of 356 bp.

E1 alpha cDNA