Input: We conclude that transcription activation by LEF-1 in vitro is a chromatin-dependent process that requires a functional trans-activation domain in addition to the HMG domain.

HMG domain


Input: TH-SH3 binding in vitro is abolished by specific, single amino acid substitutions within the Btk TH domain or the Fyn SH3 domain.

TH

Btk TH domain

Fyn SH3 domain


Input: These results indicate that K-glypican is a novel GPI-anchored HSPG involved in embryonic development.

K-glypican

GPI-anchored HSPG


Input: Protein S levels were virtually undetectable at the time of admission and failed to respond to infusions of fresh frozen plasma, despite correction of other procoagulant and anticoagulant factors.

Protein S


Input: The test was not performed in 3923 patients because of contraindications.


Input: The ubiquitous transcription factor Oct-1 forms complexes with an octamer motif present within FPIV by gel shift analysis with liver and kidney extracts, making Oct-1 an intriguing candidate for partnership in androgen regulation.


Input: We used deletion analysis and transfection assays with reporter gene constructs to examine the transcription control elements in the 5' flanking region of the human EpoR gene.

human EpoR gene


Input: Incubation of the purified fusion proteins with [gamma-32P] ATP in an in vitro assay showed that both proteins were capable of autophosphorylation.


Input: The character of specific immune response in 101 immunized children and in 12 adults belonging to a high risk group with respect to VHB.


Input: After nadolol, heart rate decreased (-22 +/-8%), and so did PBV and PBF (8. 8 +/-3. 4 vs.


Input: Adrenergic system activation, indicated by metanephrine/epinephrine ratio, increased with time in losing males, except that after one month of cohabitation, turnover returned to levels that equaled those of control animals.


Input: Transabdominal repair of type IV thoraco-abdominal aortic aneurysms.


Input: A.


Input: Primer extension and cDNA cloning were used to isolate the complete 5' end of the Nramp1 mRNA.

Nramp1 mRNA


Input: Primer extension and S1 nuclease mapping experiments were used to locate the transcription initiation site of Nramp1 and revealed the presence of one major and several minor initiation sites.

S1 nuclease


Input: Sequence analysis of the 5'-flanking region of the CD69 gene revealed the presence of a potential TATA element 30 base pairs upstream of the major transcription initiation site and several putative binding sequences for inducible transcription factors (NF-kappa B, Egr-1, AP-1), which might mediate the inducible expression of this gene.

CD69 gene

NF-kappa B


Input: The plasmin-derived D (approximately 105-kDa) product, however, could be cross-linked into DD dimers.

plasmin-derived D (approximately 105-kDa) product


Input: All clinical isolates were concomitantly tested by disk diffusion and agar dilution procedures as outlined by the National Committee for Clinical Laboratory Standards.


Input: IgE levels showed higher values compared to normal individuals and IgE levels were higher in children groups than in adults regardless of the intensity of infection.

IgE

IgE


Input: Tissue-specific expression of the tmy-1 gene was determined by microinjection of a promoter/lacZ fusion gene and with immunohistochemistry by using affinity-purified tissue-specific anti-tropomyosins.

tmy-1 gene

promoter/lacZ fusion gene

tissue-specific anti-tropomyosins


Input: The nucleotide sequence of the chloroplast (cp) DNA from maize (Zea mays) has been completed.


Input: Investigation of the control of coronavirus subgenomic mRNA transcription by using T7-generated negative-sense RNA transcripts.


Input: Initiation of translation of the human hepatitis C virus (HCV) RNA genome occurs by internal ribosome entry into the 5' noncoding region (5' NCR) in a cap-independent manner.


Input: Mean longitudinal extension of the epidural lesion was 2. 6 vertebral segments.


Input: The association of p255 with splicing complexes is suggested by the finding that mAb CC3 can inhibit in vitro splicing and immunoprecipitate pre-messenger RNA and splicing products.

mAb CC3


Input: L-735, 524 free base or sulfate salt was administered orally as suspension, solution or in solid dosage forms to fasted or fed Beagle dogs.


Input: Doppler ultrasound studies of long-term follow-up of children with hemolytic-uremic syndrome


Input: Thus, endemic cumlations of hepatitis A diseases are possible.


Input: The properties of the phi 29 SSB-ssDNA complex are described.

SSB-ssDNA


Input: This shows that the characteristically diffuse banding pattern of plant nuclear proteins interacting with the G-box is also observed in a binding assay using only one recombinant GBF.

recombinant GBF


Input: We studied 120 male and 42 female patients with early CAD who were unrelated to each other but were from families in which at least one other sibling had early CAD.


Input: The physical linkage of the FHR2 and the factor H genes provides additional evidence for a close relatedness of complement factor H and the factor H-related proteins.

factor H genes

complement factor H

factor H-related proteins


Input: Genomic structure and chromosomal location of the mouse pre-T-cell receptor alpha gene.

mouse pre-T-cell receptor alpha gene


Input: The third domain had the motif of a cAMP response element (CRE).


Input: The tyrosine-phosphorylated state of CAK beta was not reduced on trypsinization, nor enhanced in response to plating 3Y1 cells onto fibronectin.

CAK beta

fibronectin


Input: Our results suggest that while many muscle gene E-boxes are capable of binding the previously characterized spectrum of MDF/bH-L-H heterodimers in vitro, MCK-L type E-boxes probably bind qualitatively different factors in vivo.

MDF/bH-L-H heterodimers

MCK-L


Input: A single-case experimental ABAB multiple baseline design was employed to test for treatment effectiveness.


Input: These clones were found to share a common domain encoded by p (CA) n repeats; a simple sequence length polymorphism (SSLP).


Input: In one glioblastoma cell line, a Shc-associated p190 was identified as the activated PDGFR.

Shc

PDGFR


Input: The serum concentration of iP before dialysis (HD) was on average 3. 06 (+/-0. 81) mmol/l and D was on average 55. 6 (+/-10. 0) mmol.


Input: A significant correlation between a number of functional parameters of gastric secretion, incretion and histological changes of gastric mucosa was found in patients with chronic gastritis.


Input: The TAF factor appears to be particularly significant in OCD.


Input: RNase protection analyses indicate that either 61-kDa CaM PDE mRNA or structurally related transcripts encoding different CaM PDE isoforms are expressed in a tissue-specific manner.

RNase

61-kDa CaM PDE mRNA

CaM PDE isoforms


Input: Little or no protection was detected using adrenal cortex, adrenal medulla, liver, kidney cortex, spleen, or T-lymphocyte total RNA.


Input: The PDGFR mutants that failed to associate with PLC gamma were not able to mediate the PDGF-dependent production of inositol phosphates.

PDGFR mutants

PLC gamma

PDGF


Input: We found a direct correlation between the levels of transcription of the acc genes and the rate of cellular growth.

acc genes


Input: The hybridizing clone of V. vulnificus chromosomal DNA complemented a V. cholerae fur mutant.

V. cholerae fur mutant


Input: We generated transformed B lymphoblast cell lines from controls, from four patients with p47-phox-deficient chronic granulomatous disease, and from three parents.

phox


Input: RNase protection and primer extension assays confirmed that the 5' non-coding exon is included in the DDT1 aFGF mRNA and that a major transcription start site is approximately 136 bp upstream of the 5' non-coding splice junction of this exon.

RNase

aFGF mRNA


Input: These results suggest that FK 506 is a useful immunosuppressive agent in kidney transplantation.


Input: The roles of phorbol esters and cyclic AMP in mediating the GnRH response were also investigated.

GnRH


Input: RT-PCR using 1. D-specific primers showed that kidney, brain and prostate do not express 1. D mRNA even though kidney and brain are the most abundant source for aFGF protein.

aFGF protein


Input: Molecular cloning and characterization of two genes encoding gp138, a cell surface glycoprotein involved in the sexual cell fusion of Dictyostelium discoideum.

genes encoding gp138


Input: Two-dimensional phosphotryptic analyses indicate that phosphorylation on Ser-12 and Ser-48 in unstimulated cells is associated with the ability of overexpressed pp60c-src to potentiate beta-adrenergic signalling.


Input: Piroximone is a new phosphodiesterase III inhibitor that combines inotropic and vasodilator properties.

phosphodiesterase III


Input: Cytogenetic studies were performed in lymphocytes from hospital workers exposed to low doses of radiation (1. 6-42. 71 mSv).


Input: To study the origin of different fMLF-R transcripts, the genetic linkage of chemotactic receptor genes, and the regulation of fMLF-R gene expression, we determined the copy number, chromosomal location, structural organization, and 5'-flanking sequence of the human fMLF-R gene.

fMLF-R transcripts

fMLF-R gene

human fMLF-R gene


Input: The first exon encodes 66 bp of the 5'-untranslated sequence, while exon 2 encodes the coding and 3'-untranslated sequences.


Input: The genomic structure of four members of the SRC-family revealed nearly identical exon/intron boundaries within the catalytic domain of this family.

SRC-family


Input: Since we have observed effects of growth factors and cAMP as well as estradiol (E2) on regulation of expression of some genes stimulated by the estrogen receptor (ER), we have undertaken studies to examine directly whether activators of protein kinases can modulate transcriptional activity of the ER.

estrogen receptor

ER

ER


Input: Using the polymerase chain reaction, Whipple-specific DNA fragments of 284 base pairs from the genome of the Whipple bacterium (Tropheryma whippelii) were demonstrated.


Input: RNA polymerase bound to the + 10A promoter partially protects a 20 base-pair sequence from DNase I digestion upstream of the start site.

RNA polymerase

DNase I


Input: Salivary sodium, calcium, and magnesium concentrations were significantly higher in the SLE patients with systemic lupus erythematosus, whereas potassium and total protein concentrations and amylase activity did not differ significantly from the controls.

amylase


Input: Chem.


Input: Recombinant plasmid pFV100 was subsequently isolated by its ability to complement B-band expression in ge6.


Input: The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae.


Input: Protein phosphorylation appears to play a critical role in uPA gene expression in these cells; protein kinase C-activating phorbol esters cooperate with pp60v-src to synergistically increase uPA mRNA, whereas cyclic AMP (cAMP)-dependent protein kinase-activating agents (e. g., 8-bromo cAMP) repress uPA mRNA levels.

uPA gene

protein kinase C

uPA mRNA

cyclic AMP (cAMP)-dependent protein kinase

uPA mRNA


Input: This 300 bp 5'-upstream sequence of K3 keratin gene, which can function in vitro as a keratinocyte-specific promoter, contains two clusters of partially overlapping motifs, one with an NFkB consensus sequence and another with a GC box.

K3 keratin gene

NFkB


Input: BACKGROUND: Delineation of the morphologic aspects of age-related macular degeneration (ARMD) is helpful in correlation with the clinical features and may contribute to understanding the pathogenesis.


Input: An abundant 1. 1-kb virion-sense polyadenylated RNA and four complementary-sense polyadenylated RNAs of 1. 7, 1. 5, 1. 3, and 0. 7 kb have been identified by northern blot hybridization, confirming the bidirectional transcription strategy implied by the arrangement of ORFs.


Input: Risk factors associated with a high seroprevalence of hepatitis C virus infection in Egyptian blood donors.


Input: Here the cloning and molecular analysis of the Zm-ERabp1, Zm-ERabp4, and Zm-ERabp5 genes is presented.

Zm-ERabp5 genes


Input: This agent, isolated from the fungus Streptomyces tsukubaensis, has a mechanism of action similar to that of cyclosporine.


Input: DNase I footprinting of the proximal promoter revealed four regions of protection.

DNase I


Input: Finally, the stability of the nucleotide binding function of the two proteins is similar as assessed by sensitivity to urea.


Input: In addition, an mck1 mds1 mrk1 triple disruptant was viable.

mck1 mds1 mrk1


Input: However, there were some properties of Rak that are distinct from Src-like kinases: (a) expression of Rak was predominantly in epithelial-derived cell lines and tissues, especially normal liver and kidney, and cell lines of breast and colon origin; (b) Rak does not harbor the NH2-terminal glycine essential for myristylation and membrane localization; and (c) Rak possesses a putative bipartite nuclear localization signal in the SH2 domain, and subcellular fractionation studies revealed that p54rak resides predominantly in the nucleus.

Rak

Src-like kinases

Rak

Rak

Rak

SH2 domain


Input: A small amount of HSP81-1 mRNA was detected only in roots.

HSP81-1 mRNA


Input: Cell adhesion and migration assays demonstrate that alpha 6 beta 1 is the major laminin receptor in undifferentiated F9 cells as well as F9-derived PE cells.

alpha 6 beta 1

laminin receptor


Input: No local destruction by tumor or infection could be demonstrated apart from HIV infection.


Input: Among the mixed race persons one Chukcha-Eskimo had AS, one Eskimo-Russian had psoriatic arthritis (PsA).


Input: Our data complement other studies of circumpolar populations and reinforce the reported high prevalences of SPA and HLA-B27 among those populations.


Input: Clinical studies SY5555 was administered to 45 patients with various infectious diseases (2 with acute pharyngitis, 8 with acute tonsillitis, 4 with lacunar tonsillitis, 3 each with acute bronchitis, pneumonia and pertussis, 7 with scarlet fever, 3 with impetigo contagiosa, 6 with acute urinary tract infections, 2 with balanoposthitis and 1 each with cervical lymphadenitis, S. S. S. S., vulvitis and acute colitis) at daily doses between 3. 4-10 mg/kg, t. i. d., for 3-14 days.


Input: Although most SH2-pTyr interactions occur between two different types of molecules, some appear to involve only a single molecular type.

pTyr


Input: RESULTS: Closure time of fistulas in patients receiving TPN + somatostatin was significantly shorter (13. 86 +/-1. 84 versus 20. 4 +/-2. 89 days) than in those receiving TPN alone.

somatostatin


Input: Scratching during sleep in children with atopic dermatitis is associated with increased VO2.


Input: Within-subject BP differences between fish oil and corn oil treatment were similar for Dinamap (3. 2 +/-1. 8/2. 5 +/-1. 0 mm Hg) and for 24-h ABP (2. 5 +/-1. 0/2. 3 +/-0. 8 mm Hg), but were more significant with the latter.


Input: Escherichia coli JRG582 is an ampD ampE deletion derivative of strain HfrH and accordingly it is derepressed for expression of the cloned inducible beta-lactamase gene of Citrobacter freundii, carried on plasmid pNU305.

ampD ampE

beta-lactamase gene


Input: Such a mechanism may allow acceleration of degenerative joint conditions, and may account for the increased prevalence of such conditions seen with HMS subjects.


Input: Solitary thyroid nodule.


Input: Male contraception: ideas for the future.


Input: While daily food intake was almost constant regardless of the dietary protein level, water intake and urine volume increased with increasing the dietary protein.


Input: We propose that Mad and Medea encode rate-limiting components integral to dpp pathways throughout development.

Mad

Medea

dpp


Input: Transcriptional regulation of the vacuolar H (+)-ATPase B2 subunit gene in differentiating THP-1 cells.

vacuolar H (+)-ATPase B2 subunit gene


Input: However, the inability to export RNA from the nucleus to the cytoplasm was not limited to a particular phase of the cell division cycle.


Input: An E box element is required for the expression of the ad4bp gene, a mammalian homologue of ftz-f1 gene, which is essential for adrenal and gonadal development.

ad4bp gene

mammalian homologue of ftz-f1 gene


Input: Inhibition assays performed with over 30 different natural and synthetic sialylated and/or sulfated compounds are utilized to define in greater detail specific structural features involved in oligosaccharide-protein binding.


Input: The amino acid sequence of the protein in the region of the specificity pocket is similar to that of S. griseus proteases A, B, and C.

S. griseus proteases A, B, and C


Input: This experimental design was used to determine the effect of displacement of the alpha 4-2 binding site on the repression of alpha 4 gene transcription by ICP4.

alpha 4-2 binding site

alpha 4 gene


Input: Immediate-early transcription from the channel catfish virus genome: characterization of two immediate-early transcripts.

immediate-early transcripts


Input: The GRE at nucleotide 7640 is a composite GRE (cGRE) containing an overlapping activator protein-1 (AP-1) motif for the c-jun homodimer and c-jun/c-fos heterodimer.

activator protein-1

c-jun homodimer

c-jun

c-fos


Input: In contrast to some results previously published for a very close sequence variant (see ref.


Input: Transcriptional activation by thyroid hormone (T3) requires interactions between the T3 receptor (TR) and T3 response elements (TREs) composed of two copies of sequences related to AGGTCA.

T3 receptor

TR


Input: A multivariate analysis of risk factors for relapse examined age, WBC at diagnosis, blast count at diagnosis, percentage of marrow blasts, FAB subtype, the number of remission induction courses to achieve a remission, maintenance therapy, consolidation therapy, marrow cell dose, donor-recipient sex, GVHD prophylaxis regimen and isolation and decontamination in laminar airflow rooms.

FAB


Input: Carnitine palmitoyltransferase (CPT) II deficiency is the most common inherited disorder of lipid metabolism affecting skeletal muscle.

Carnitine palmitoyltransferase (CPT) II


Input: We show that these three gain-of-function mutants differ considerably in their ability to bypass the sex determination signal, with SxlM4 being the strongest and SxlM1 the weakest.


Input: We show that these three gain-of-function mutants differ considerably in their ability to bypass the sex determination signal, with SxlM4 being the strongest and SxlM1 the weakest.


Input: Blood pressure also was increased by lidocaine (6 mg kg-1).


Input: Anesthesiologists often use more than one drug in a patient to achieve a target response, such as a desired blood pressure.


Input: We suggest that this gene cluster codes for (parts of) a multisubunit cytochrome c haem lyase.

multisubunit cytochrome c haem lyase


Input: In this paper, a comparison between the number and shape of corneal endothelial cells has been performed in 25 patients before and 6 months after PRK.


Input: Standard reference sources indicate that an able-bodied 11-year-old child of comparable height requires 1, 493 kcal/d for support of basal metabolic functions.


Input: In contrast to the myoD promoter, the myoD enhancer shows striking conservation between humans and mice both in its sequence and its distal position.

myoD promoter

myoD enhancer


Input: However, a clear difference exists between myoblasts and 10T1/2 cells (and other non-muscle cell types) in the chromatin structure of the chromosomal myoD core enhancer, suggesting that the myoD enhancer is repressed by epigenetic mechanisms in 10T1/2 cells.

myoD core enhancer

myoD enhancer


Input: Using Ki-ras-transformed 3T3 cells as a model system, we show that both RA and the' dissociating' retinoids inhibit anchorage-independent cell proliferation, suggesting that retinoid-induced growth inhibition may be related to AP1 transrepression.

Ki-ras


Input: The Oct and HMG2 proteins also interact in vivo.

Oct

HMG2 proteins


Input: Atopic dermatitis is an " itch which rashes and not a rash which itches " and therefore, any patient treatment program should address the multiplicity of potential trigger factors that provoke this itching.


Input: Primer extension experiments showed that there are two transcription initiation sites 16 bp apart in the mouse type 2 receptor gene.

mouse type 2 receptor gene


Input: The beta subunit of the Fc epsilon R1 is a 33-kDa tyrosine phosphoprotein, but the p33 Grb2-binding protein described in the present report is not the Fc epsilon R1 beta chain and its identity is unknown.

Fc epsilon R1

p33 Grb2-binding protein

Fc epsilon R1 beta chain


Input: To study the mechanisms as well as magnitude of the transmembrane transfer of bacterial products from the dialysate, we developed a computerized in vitro dialysis model which provides continuous pressure recording from the arterial, venous, dialysate inflow and outflow ports.


Input: After 24 hour incubation, total cell-associated IL-1Ra and IL-1 beta were measured by specific radioimmunoassay.

IL-1 beta


Input: In contrast, recent evidence suggests that children with sickle-hemoglobin C disease do not develop functional asplenia before 3 to 4 years of age and thus may not benefit from penicillin prophylaxis.

sickle-hemoglobin C


Input: Deletion analysis indicates that TBP and hTAFII18 bind to distinct domains of hTAFII28. hTAFII18 also interacts with TBP, but it interacts more strongly with hTAFII28 and hTAFII30.

TBP

TBP


Input: Vascular endothelial cells undergo profound changes upon cellular activation including expression of a spectrum of cell activation-associated genes.


Input: Because ATF-1 and CREM are known to bind to cAMP response elements (CRE), this functional sequence was named the kappa E3'-CRE.

CREM

kappa E3'


Input: The amino acid sequences of the known largest subunits of DdRPs from different species contain highly conserved regions.

DdRPs


Input: The TTG-2 gene has been identified at the site of chromosomal translocations in acute T-cell leukemia' s (T-ALL).

TTG-2 gene


Input: In vitro studies with blood cells incubated with acetate or bicarbonate ions in concentrations, which are observed in vivo during hemodialysis, suggest that probably these ions do not directly affect superoxide anions generation, erythrocyte SOD-1 and catalase activities and erythrocyte membrane lipid peroxidation.

catalase


Input: Short therapy with omeprazole 20 mg/b. i. d., clarithromycin 500 mg/b. i. d., and CBS 120 mg/q. i. d. is a safe, well tolerated combination that achieves a 80. 6% eradication rate of H. pylori and duodenal ulcer healing rates as good as those achieved by omeprazole 20 mg/d when given for 4 wk.


Input: The concentration of mite allergen was very low (mean 0. 18 micrograms Der p milligrams sieved house dust), whereas that of cat allergen was high in homes with a cat (80. 8 micrograms Fel d milligrams) but also in homes with no cat (3. 2 micrograms Fel d milligrams).


Input: CONCLUSIONS: A comparison of the LysU crystal structure with the structures of seryl-and aspartyl-tRNA synthetases enables a conserved core to be identified.

LysU

seryl-and aspartyl-tRNA synthetases


Input: Whole bowel irrigation is a recently described technique to enhance the passage of drugs already beyond the pylorus.


Input: The MPS1 open reading frame has been fused to those that encode the LexA protein or the GST protein and both of these constructs function in yeast.

MPS1 open reading frame

LexA protein

GST protein


Input: Hematopoietic growth factors have already had an enormous impact on transfusion practice by eliminating or reducing the need for red blood cell transfusions in a variety of anemic states characterized by an absolute or relative decrease in erythropoietin.

Hematopoietic growth factors

erythropoietin


Input: However, the mouse has previously been shown to possess only three forms of ADH.

ADH


Input: During IC breaths and following EC and VC breaths at rest, end-tidal CO2 pressure (PET, CO2) fell by 7. 5, 8. 5 and 9. 5 mmHg, respectively.


Input: Phylogenetic analyses of 19 amino acid sequences of 6 related protein types indicate that actin-associated proteins related to gelsolin are monophyletic to a common ancestor and include flightless proteins.

actin

gelsolin

flightless proteins


Input: No homologs of other members of the Surfeit gene cluster were detected in close proximity to the D. melanogaster Surf-3/rpL7a gene.

Surfeit gene cluster


Input: Moreover, we found that cyclin E, in contrast to cyclin D1, was required for the G1/S transition even in cells lacking retinoblastoma protein function.

cyclin E

cyclin D1

retinoblastoma protein


Input: The predicted amino acid sequence of the SGC1 gene product includes a region with substantial similarity to the basic-helix-loop-helix domain of the Myc family of DNA-binding proteins.

SGC1 gene product

Myc family


Input: By creating Pax-6-BSAP fusion proteins, we were able to identify a short amino acid stretch in the N-terminal part of the paired domain which is responsible for these differences in DNA-binding specificity.

BSAP

paired


Input: To establish a possible association between familial dysfibrinogenemia and thrombophilia, data on cases with both affections were collected in a study within the framework of the SSC Subcommittee on Fibrinogen of the International Society on Thrombosis and Haemostasis.

Fibrinogen


Input: Conjugated estrogens shorten bleeding time in uraemia: a possible role of serotonin?


Input: These six districts have an area of 34, 000 km2 and hold a population of 30 million.


Input: According to symptoms, signs, imaging features, operation findings, the original places and the expansive directions of the tumor, they were divided into four clinical types: sellar, clival, occipito-temporal and extent.


Input: The cases included 35 de novo diffuse aggressive lymphomas (DAL; 19 large-cell, 4 mixed-cell, and 12 large-cell immunoblastic), 52 transformed aggressive lymphomas derived from follicular lymphomas (TFL), 42 indolent follicular lymphomas (FL), 14 mantle cell lymphomas (MCL), and 27 small noncleaved cell lymphomas (SNCL).


Input: Icterus and beta-thalassemia in Congolese children in Brazzaville


Input: Female patients with breast cancer diagnosed between 1982 and 1991 at Roswell Park Cancer Institute (RPCI) in Buffalo, New York, who provided information on their cigarette smoking history at the time of their diagnosis were included.


Input: Upon analysis of the tissue distribution of AAMP, it was found to be expressed strongly in endothelial cells, cytotrophoblasts, and poorly differentiated colon adenocarcinoma cells found in lymphatics.

AAMP


Input: Data from the V-HeFT II show that at 2-year follow-up, a progressive rise of plasma norepinephrine was observed in both treatment arms, suggesting that disease progresses despite treatment with either an angiotensin-converting enzyme inhibitor, enalapril, or vasodilator therapy with hydralazine/isosorbide dinitrate.

angiotensin-converting enzyme


Input: Analysis of Bcl-2/Bcl-2 homodimerization using both in vitro binding assays as well as a yeast two-hybrid method provided evidence in support of a head-to-tail model for Bcl-2/Bcl-2 homodimerization and revealed that sequences within the NH2-terminal A domain interact with a structure that requires the presence of both the carboxyl B and C domains in combination.


Input: The protein is composed of a central alpha-helical portion with globular domains at both NH2 and COOH termini, and the epitope to the monoclonal antibody resides in the central alpha-helical stalk.


Input: Radioligand binding was indistinguishable for both transiently expressed constructs.


Input: Diagnosis of FHCS has been weighed upon laparoscopic findings.


Input: Human papillomavirus type 31b late gene expression is regulated through protein kinase C-mediated changes in RNA processing.

Human papillomavirus type 31b late gene

protein kinase C


Input: Interestingly, virions also contained smaller proteins that reacted with antibodies specific for the accessory proteins as well as SN and CAT fusion partners.

SN

CAT fusion


Input: Studies using an inhibitor or a mutant Lb proteinase indicated that stimulation of IRES-driven translation is mediated via proteolysis of some cellular component (s).

mutant Lb proteinase


Input: Restriction mapping analysis localized this cDNA to the HHV-6A (U1102) genomic BamHI G fragment, at the right end of the unique long segment of the genome and to the SalI L and SalI O fragments within the left and right terminal direct repeat regions, respectively.

HHV-6A (U1102) genomic BamHI G fragment

SalI L

SalI O fragments


Input: For replication reporter constructs where E1 and E2 are supplied in trans by the respective expression vectors, distance between the half sites seems to play a major role, yet the phasing relationships are measurable.


Input: As it had been previously reported that the 18-bp palindrome contains sufficient nucleotide sequence information for E1 binding, we speculate that a minimal E1 recognition motif is presented in each half site.


Input: METHODS: Out of 171 patients receiving anticoagulation between July 1992 and December 1993, 83 patients with hemispheric embolisms received heparin within 72 hours from onset (activated partial thromboplastin time [aPTT] 1. 5 times control value).

thromboplastin


Input: In the commercially available intravenous formulation of Cyclosporin A (Sandimmun), polyoxyethylated castor oil (Cremophor EL) is used as a solubilizing agent.


Input: Sequence comparisons of prokaryotic RCR initiators has revealed a set of three common motifs, two of which, a putative metal coordination site and a downstream active-site tyrosine motif, could be tentatively identified in parvoviral replicator proteins.

prokaryotic RCR initiators

parvoviral replicator proteins


Input: The mean marginal discrepancy of provisional restorations was compared for restorations fabricated from stone, low-viscosity poly (vinyl siloxane), and medium-viscosity poly (vinyl siloxane).


Input: The characterized Aplysia Afurin2 is a candidate PC that may play an important role in the processing of egg-laying hormone (ELH)-related precursors in the secretory cells of the atrial gland.

Aplysia Afurin2

PC

egg-laying hormone

ELH


Input: Rats treated with 8-OH-DPAT were not impaired in their ability to learn a visual discrimination in a water maze.


Input: The term endovascular papillary haemangioma is suggested.


Input: In addition, two internal promoters, PmiaA and P1hfq were identified and mapped to 201 and 837 nucleotides upstream from the respective translation start sites.

PmiaA


Input: These results indicate that mutL, miaA, and hfq expression could be regulated by multiple mechanisms, including degree of cotranscription from upstream genes, modulation of internal promoter strength, and by RNase E activity.

mutL

miaA

hfq

RNase E


Input: Coronary T1 and T2 weighted images were obtained.


Input: The 2 kb of 5'-flanking region and the 1. 1 kb of the entire sGTH alpha subunit coding region were sequenced from the genomic clone, sGTH alpha-G1.

sGTH alpha subunit

sGTH alpha-G1


Input: Functional analysis of the sGTH alpha subunit promoter by the transient transfection of several sGTH alpha/CAT chimeric plasmids into rainbow trout pituitary cells suggests that its pituitary-specific expression is GSE-dependent.

sGTH alpha subunit promoter

sGTH alpha

CAT

GSE


Input: Indium-111 OncoScint CR/OV and F-18 FDG in colorectal and ovarian carcinoma recurrences.


Input: His carnitine palmitoyltransferase (CPT) I and II activities were 0. 06 and 0. 12 nmol/min/mg protein, as compared with a mean value of 0. 22 +/-0. 14 and 0. 27 +/-0. 07 nmol/min/mg protein, respectively, in control subjects.

carnitine palmitoyltransferase (CPT) I and II


Input: The Myc LZ was found to prevent homodimeric interactions, thus explaining Myc inability to homodimerize efficiently.

Myc LZ

Myc


Input: Thus, VF resistant to defibrillation is not necessarily associated with both toxic plasma drug level and remarkably decreased conduction.


Input: The smallest active FecR derivative contained 59 amino acid residues as compared to the 317 residues of wild-type FecR.

active FecR derivative

wild-type FecR


Input: The gene pairs psbB-psbT and psbH-psbN are cotranscribed from opposite strands.

psbB

psbT

psbH

psbN


Input: The predicted amino acid sequence contains regions identical to the sequences of peptides derived from bovine liver eIF-2B alpha subunit.

bovine liver eIF-2B alpha subunit


Input: Expression of this cDNA in vitro yields a peptide which comigrates with natural eIF-2B alpha in SDS/polyacrylamide gels.

natural eIF-2B alpha


Input: When RNA encoding the tail domain of desmoglein was coinjected with plakoglobin RNA, both the dorsalizing effect and nuclear accumulation of plakoglobin were suppressed.

desmoglein

plakoglobin RNA

plakoglobin


Input: Six of them, NUC1, PRP21 (also called SPP91), CDC6, CRY2, the gene encoding the ribosomal protein S24 and the gene coding for a hypothetical protein of 599 amino acids, have been sequenced previously.

ribosomal protein S24


Input: Intrastriatal grafts of nigral and adrenal tissues have been found to be effective in alleviating many of the simple motor and sensorimotor deficits associated with lesions of the nigrostriatal dopamine system.


Input: OBJECTIVE: To determine the impact of the introduction of clarithromycin and azithromycin on the treatment and survival of patients with AIDS and disseminated Mycobacterium avium complex (DMAC).


Input: Thereafter, the aggregation rose to the initial 100% value 4 h after drug application and remained at this level during the observation period. (ABSTRACT TRUNCATED AT 250 WORDS)


Input: Growth curves indicated that proliferation of clone CA9 in the presence of 10% serum was reduced by 60% compared with clone ME10.


Input: The protein coding region, 1, 696 bps long, is divided by an intron into two exons.


Input: The UAS of the AAC2 gene contains at least two distinct motifs for DNA-binding transcriptional activators, including one which is identical with the core HAP2/3/4 binding motif, and a second one with the ABF1 consensus binding sequence.

AAC2 gene

HAP2/3/4 binding motif

ABF1 consensus binding sequence


Input: The emerging complexity of the 5' regulatory region of the GH receptor gene was emphasised by the observation that probes derived from exon 1B and the distal 3' intron boundary do not hybridise with previously cloned genomic sequences that span the liver-specific P1 promoter and exon 2.

GH receptor gene


Input: A polymorphic dinucleotide (GT/CA) n repeat contained in the NHE5 cosmid was identified and developed into a microsatellite PCR marker.


Input: The proteins are more than 90% identical to each other within the protein kinase domain but only 51-59% identical to other casein kinase I isoforms within this region.

casein kinase I isoforms


Input: We used two approaches to ascertain whether CDP/cut serves as a repressor of gp91-phox gene expression.

CDP

cut

phox


Input: Despite the activation of these intracellular signaling molecules, PDGF beta receptor activation elicited no detectable effect on cell proliferation or differentiation.

PDGF beta receptor


Input: UAS1 is the binding site for the transcriptional regulator Adr1p.


Input: In the context of the ADH2 upstream regulatory region, including UAS1, working in concert with the ADH2 basal promoter elements, UAS2-dependent gene activation was dependent on orientation, copy number, and helix phase.

ADH2 upstream regulatory region

ADH2 basal promoter elements


Input: Induction in AP-1 DNA binding correlates with a concomitant GH trans-activation of c-jun and c-fos genes described previously.

GH

c-jun

c-fos genes


Input: Inactivation of MAP kinases occurs via a specific phosphatase, MKP-1.

MAP kinases


Input: Short-course amphotericin B therapy for candidemia in pediatric patients.


Input: Furthermore, 45Ca-binding assays revealed that CCaMK directly binds Ca2 +.

CCaMK


Input: The protein expressed from the cloned cDNA is secreted into the culture medium and yields of up to 40 mg per litre have been obtained.


Input: Plasmids pAMS12, pAMS13 and pAMS14 were transformed into a laboratory strain of Saccharomyces cerevisiae, whereas pAMS15 was stably introduced into two commercial wine yeast strains.


Input: The maximum induction of ACC-oxidase transcripts occurred at about 6 h after excision, while the maximum enzyme activity was observed at 24 h.

ACC-oxidase transcripts


Input: Within their polypeptide chain, they all contain those conserved features that define a plant CDPK; kinase catalytic sequences are linked to a calmodulin-like regulatory domain through a junction region.

CDPK

calmodulin-like regulatory domain


Input: Repair of this insertion by homologous recombination restores the activity of the hprt locus, thus confirming the site of mutation.

hprt locus


Input: The timing of fla gene expression in the cell cycle is determined by specialized forms of RNA polymerase and the appearance and/or activation of regulatory proteins.

fla gene

RNA polymerase


Input: Primer extension experiments revealed a strong transcription initiation site 102 bp upstream of the translational start site.


Input: Polypeptides of the same apparent sizes are detected in spores of a cotE null mutant, on which basis we infer that the products of the cotJ operon are required for the normal formation of the inner layers of the coat or are themselves structural components of the coat.

cotE

cotJ operon


Input: Based on the estimated values of divergence of apobec1 sequences in terms of the numbers of synonymous and non-synonymous suhstitutions per site, we found that apobec1 is a fairly rapidly evolving protein.

apobec1 sequences


Input: EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine " fingers " and contains a calmodulin-binding IQ motif.

calmodulin-binding IQ motif


Input: Nucleotide sequences of the clones revealed that one clone, cap3, contained an open reading frame (ORF) that would code for a 26-amino acid, cysteine-rich peptide with significant homology to Neurospora crassa copper metallothionein.

Neurospora crassa copper metallothionein


Input: Sensing with chemically and biologically modified carbon electrodes.


Input: Elevation of the tissues of the face is essentially vertical and acts on the forehead, temporal region, gaze and cheekbones.


Input: This region binds two ubiquitous nuclear factors, USF/MLTF and the CAAT-binding transcription factor/nuclear factor 1 (CTF/NF1).

USF

MLTF

CAAT-binding transcription factor

nuclear factor 1

CTF


Input: The potential impact of using a rapid diagnostic test (Strep A OIA) on detection and treatment of group A beta-hemolytic streptococcal (GABHS) pharyngitis in a large-volume pediatric and adolescent clinic was examined.


Input: The bHLH proteins function as potent transcriptional activators of tissue-specific genes by forming heterodimers between ubiquitous and cell-restricted family members.

bHLH proteins


Input: YAC and cosmid contigs spanning the BRCA1 region were used to select cDNA clones from pools of cDNAs derived from human placenta, HeLa cells, activated T cells, and fetal head.

BRCA1 region


Input: This study assesses the feasibility and toxicity of adoptive immunotherapy with tumor infiltrating lymphocytes and recombinant interleukin-2 in 29 patients who underwent resection for stage III non-small-cell lung cancer.

recombinant interleukin-2


Input: The present study describes the cell volume dynamics in intact rat hearts, during ischemia and after reperfusion.


Input: In contrast, COUP-TF alone had no effect on repCRS2-dependent reporter gene activity.

COUP-TF


Input: DNA sequencing and Southern blot analyses established that the cDNA clones are derived from two different genes.


Input: Mutation of the Sp1 element, which abolishes Sp1 binding, results in a 6-10-fold reduction in reporter activity.

Sp1 element


Input: The c-myc gene is overexpressed in a variety of tumor types and appears to play an important role in the abnormal growth of a number of cell types.

c-myc gene


Input: Schooling is found to be related to good health even after controlling for differences in observable health inputs.


Input: With this bisected diastolic driving, the abnormal echo disappeared completely.


Input: It acts on Cdks in the G1 and S phases of the cell cycle, and also binds to proliferating cell nuclear antigen (PCNA), blocking DNA replication in vitro.

Cdks

proliferating cell nuclear antigen

PCNA


Input: Two major and one minor transcription initiation sites were assigned to positions + 1 and + 24 and position + 14, respectively, by a combination of ribonuclease protection, primer extension, and 5' RACE analyses.


Input: Further, the ORFs of components 3 and 5 potentially encoded proteins of about 20 kDa, the size of the BBTV coat protein.

BBTV coat protein


Input: CodY does not have any homologues in the data-bases.

CodY


Input: OBJECTIVE: To investigate the incidence and presentation of acute pernicious or fulminating beriberi in a general district hospital.


Input: Unlike most other small G proteins which are expressed ubiquitously, TTF was transcribed only in hemopoietic cells as a 2. 2 kb transcript.

small G proteins

TTF


Input: An explanation explored for this lack of gene expression was that increased levels of RAR alpha or PML might suppress APL cell growth.

RAR alpha

PML


Input: Cytosolic extracts from a variety of mammalian cell lines (monkey Cos7, several mouse fibrosarcomas and human HeLa S3) demonstrated similar TGF-beta 1 dependent RNA-protein band shifts as cell extract from BALB/c 3T3 mouse fibroblasts.

TGF-beta 1


Input: The provisional reports are based mainly upon macroscopic findings, whereas the final reports include the information provided by supplementary investigations such as microscopy, histochemistry, more rarely electron microscopy, immunohistochemistry and/or microbiology.


Input: Circulating thrombomodulin: current knowledge and future prospects

thrombomodulin


Input: CPT-11 was administered as a 30-minute i. v. infusion at a dose of 350 mg/m2 diluted in 250 ml normal saline every 3 weeks.


Input: A 73 bp fragment (X1 region) of the PRB-1b promoter, located between positions-213 and-141, was sufficient to confer ethylene responsiveness to the reporter gene.

PRB-1b promoter


Input: To assess the function (s) of E74 during metamorphosis, we have isolated and characterized recessive loss-of-function mutations specific to each transcription unit.


Input: Although the extracellular domain of the TSH-R is sufficient for high affinity binding of TSH, we conclude that the hyt mutation in the fourth transmembrane domain eliminates TSH binding.

TSH-R

TSH

TSH


Input: Lipiodol was covalently conjugated with EDTB.


Input: Moreover, Western blots demonstrated at least six types of Ypt in both Cr and Vc, suggesting that these Ypt are used for household functions responsible for vesicle transport rather than for cellular differentiation.

Ypt

Ypt


Input: The absence of other regions of hybridization suggests that there are no closely related sequences (e. g., reverse transcribed pseudogenes) scattered throughout the genome and that if there are closely related genes, they must be clustered near GSTT2.


Input: However, the lens dose (3. 6 Gy/25 fractions) was higher compared to the other techniques.


Input: Antibodies to the human PTS1R recognize this protein in human, monkey, rat, and hamster cells.

human PTS1R


Input: There is a national effort to begin to ask all female patients about family violence.


Input: GnRH treatment was found to increase the phosphorylation of tyrosine residues of MAPK and to increase MAPK activity, as determined by an immune complex kinase assay.

GnRH

MAPK

MAPK


Input: Molecular cloning of an amphibian insulin receptor substrate 1-like cDNA and involvement of phosphatidylinositol 3-kinase in insulin-induced Xenopus oocyte maturation.

amphibian insulin receptor substrate 1-like cDNA

phosphatidylinositol 3-kinase

insulin


Input: We report here that in cultured Jurkat T cells, Cbl is coprecipitated with antibody against the adapter protein Grb2.

Cbl

adapter protein Grb2


Input: The effect of these cell cycle regulators is not specific to the rap1s or hmr delta A mutation, since swi6, swi4, and clb5 mutations also suppress mutations in SIR1, another gene implicated in the establishment of silencing.

hmr delta A mutation

clb5 mutations


Input: ICP4 has been shown to form tripartite complexes cooperatively with the TATA box-binding protein and TFIIB on DNA containing an ICP4 binding site and a TATA box (C.

TATA box-binding protein

TFIIB

ICP4 binding site


Input: Characterization of fus1 of Schizosaccharomyces pombe: a developmentally controlled function needed for conjugation.


Input: SRY-related cDNA encoding a protein with a high-mobility-group (HMG) box and a leucine zipper motif, which was designated SOX-LZ, was isolated from a rainbow trout testis cDNA library.

SRY-related cDNA

high-mobility-group

HMG

SOX-LZ


Input: Scalp flaps can be expanded just to the point of becoming noticeable over 4 to 6 weeks followed by scalp flap transposition and easy closure of the donor site.


Input: In the Center for Human Genetics in Leuven, predictive DNA-testing for Huntington' s disease is available as a clinical service since November 1987, initially by DNA-linkage and since mid 1993 by direct mutation analysis.


Input: Risks of chronicity following acute hepatitis B virus infection: a review.


Input: Examination of neurohumoral factors revealed a hyperactive sympathetic nervous system and an increase in plasma renin activity.

renin


Input: We compared the inhibitory effect of naturally occurring mutant hTR beta 1, artificially created hTR alpha 1 mutants, c-erbA alpha 2 and the human peroxisome proliferator-activated receptor (hPPAR) on three prototypic T3-response elements (TREs), TRE-PAL, DR + 4 and TRE-LAP.

mutant hTR beta 1

hTR alpha 1 mutants

c-erbA alpha 2

human peroxisome proliferator-activated receptor

hPPAR


Input: The amino-terminal DNA-binding domain of Pip exhibits a high degree of homology to the DNA-binding domains of members of the interferon regulatory factor (IRF) family, which includes IRF-1, IRF-2, ICSBP, and ISGF3 gamma.

Pip

interferon regulatory factor

IRF

ICSBP

ISGF3 gamma


Input: An outbreak of hepatitis A among homosexual men in Amsterdam, 1991-1993.


Input: The RAP74 subunit of TFIIF alone contained the stimulatory activity and the minimal region sufficient for stimulation corresponds to COOH-terminal residues 358-517.

RAP74 subunit

TFIIF


Input: We have generated various base substitutions and internal deletions in and around DRE (nucleotide positions-93 to-100 with respect to the transcription initiation site) of the PCNA gene in vitro and subsequently examined their effects on the binding to DREF (DRE-binding factor) and PCNA gene promote activity in cultured Drosophila Kc cells as well as in living flies.

PCNA gene

DREF

DRE-binding factor

PCNA gene


Input: The hsp70 gene family of Neurospora crassa: cloning, sequence analysis, expression, and genetic mapping of the major stress-inducible member.

hsp70 gene family


Input: The deduced amino acid sequences of each of the W3A1 ETF subunits exhibit only approximately 30% identity with the corresponding subunits of the ETF from human, rat, and Paracoccus denitrificans, which as a group are greater than 50% identical.

W3A1 ETF subunits

ETF


Input: This last region contains two sites that bind Ets-related proteins present in liver nuclear extracts as well as recombinant purified Ets-1 protein.

Ets-related proteins

recombinant purified Ets-1 protein


Input: Other assays also distinguished the processive replication of pNeo. Myc-2. 4 from the dispersive labeling of control plasmids.


Input: Therefore, it is hoped that by defining the transcriptional control of the L7 gene insights into the mechanisms that control functional fate and organization in the nervous system can be gained.

L7 gene


Input: In contrast, a Maf-related protein, Nrl, completely mimicked c-Maf actions.

Maf-related protein

Nrl

c-Maf


Input: The 27-base element interacts with a PDGF-activated serine/threonine phosphoprotein that is detected only within the nucleus of PDGF-treated 3T3 cells.

PDGF


Input: By contrast, deletion of this Ras-binding site did not diminish activation of Raf-1 kinase by Src, implying that Src and Ras can activate Raf-1 through independent mechanisms.

Ras-binding site

Raf-1 kinase

Src

Src

Ras


Input: In studies of many different phenotypically distinct cells, the CRE of the somatostatin gene promoter is a prototype of a highly cAMP-responsive element regulated by CREB.

somatostatin gene promoter

CREB


Input: The first gene, NSR1, a previously identified gene, encodes a protein involved in ribosomal RNA maturation and possibly in transport of proteins into the nucleus.


Input: Characterization of the promoter for the human 85 kDa cytosolic phospholipase A2 gene.

human 85 kDa cytosolic phospholipase A2 gene


Input: This paper describes the advantages and limitations of the main study approaches used.


Input: Comparative study of the differential white blood cell count using three automated analyzers: Coulter STKS, Sysmex NE 8000 and Technicon H-1.


Input: Characterization of FIII/YY1, a Xenopus laevis conserved zinc-finger protein binding to the first exon of L1 and L14 ribosomal protein genes.

FIII

Xenopus laevis conserved zinc-finger protein

L14 ribosomal protein genes


Input: Further studies established that the Ep-induced increase in beta-globin mRNA could be inhibited by the tyrosine kinase inhibitor genistein and the protein kinase C inhibitor Compound 3. (ABSTRACT TRUNCATED AT 250 WORDS)

Ep

beta-globin mRNA

tyrosine kinase

protein kinase C


Input: This structure of cucumisin suggests that it is probably synthesized as an inactive precursor.

cucumisin


Input: Molecular dissection of the multimeric CD3-TCR complex revealed that at least two associated polypeptides, CD3 zeta and CD3 epsilon, autonomously couple antigenic recognition event to early and late events of the intracytoplasmic activation cascade.

TCR

CD3 zeta

CD3 epsilon


Input: This study investigated the degree to which racial identity influences Mexican-Americans' performance on the L, K, and MF scales of the MMPI-2.


Input: Both can be elevated on a single vascular pedicle based on the superficial temporal artery, the double-layered temporal fascia flap.


Input: To do this, segments of DNA from the 5' flank of the initiation sites for germline epsilon RNA were ligated to a luciferase reporter gene and transfected into two mouse B cell lines, one of which can be induced to switch to IgE.

luciferase reporter gene

IgE


Input: The negative predictive value is 92%, vs 80% for the NCEP I.


Input: Oncogenic capacity of the E2F1 gene.

E2F1 gene


Input: In some of the cases of solitary lesion, serum TSH levels, serum thyroglobulin values, and 131I protein bounded iodine (131I-PBI) were measured, but there were no significant differences between successful and unsuccessful therapy.

serum TSH

serum thyroglobulin


Input: Endo16 transcripts are confined to the definitive vegetal plate in blastula stage embryos; at gastrula stage this gene is expressed throughout the archenteron, but later only in the midgut.

Endo16 transcripts


Input: A unique leucine-proline repeat element found N-terminal to the DNA-binding domain of EmBP-1 does not appear to play a role in DNA-binding or dimerization.


Input: Another full ORF was found on the opposite strand downstream from the nspC gene.

nspC gene


Input: Two related cDNAs were isolated that encode proteins that recognize the XMyoDa TATA motif.

XMyoDa TATA motif


Input: Deletion of both prfA and ponA resulted in extremely slow growth and a reduction in sporulation efficiency.

prfA

ponA


Input: In broken L-cell membranes expressing wild type or mutant M6P/IGF II receptors, 30 nM IGF II also failed to affect the pertussis toxin substrate activity.

mutant M6P/IGF II receptors

IGF II

pertussis toxin


Input: Chem.


Input: For the first time we describe deletion and point mutations within the plasma membrane family of guanylyl cyclase receptors that result in the formation of effective dominant negative proteins.

plasma membrane family of guanylyl cyclase receptors


Input: Increase in blood NEFA was further augmented by fat plus AA supplementation, but no changes in concentrations of Lys or Met in blood were found.


Input: Virol.


Input: Comparison of the deduced amino acid sequence of gamma-kafirin with the published sequences of gamma-prolamins of maize, and Coix revealed highly conserved domains.

amino acid sequence of gamma-kafirin

sequences of gamma-prolamins of maize, and Coix


Input: These results suggest that HAC1 may also be one of the meiotic genes.


Input: We characterized three Arabidopsis thaliana cDNA clones that could rescue the sterile phenotype of the Schizosaccharomyces pombe pde1 mutant, which is defective in cAMP phosphodiesterase.

Schizosaccharomyces pombe pde1 mutant

cAMP phosphodiesterase


Input: Furthermore, the identification of a Dr1-like protein in A. thaliana strongly argues for the ubiquity of this protein among eukaryotic genera and for a conserved mechanism to regulate transcription initiation that involves Dr1.

Dr1-like protein


Input: Similarly approximately 300 bp of sequence downstream of the translation terminator TGA of the beta-tubulin 2 (BTU2) gene could substitute for the 3' region of the H4-I gene.

beta-tubulin 2

H4-I gene


Input: These data demonstrate that the STR family of genes is represented in a nematode whose ancestor appeared well before the branching that gave rise to the Arthropoda and Chordata.

STR family


Input: The pre-and postoperative haemoglobin concentrations in the autologous group were lower by 15 and 10 g/L, respectively, after primary THR and by 10 g/L in both instances after revision THR.

haemoglobin


Input: The introduction of an acidic residue at the second site was essential for suppression of the Asn-285 mutation because Lys-220 and Gln-220 second-site mutants of the Asn-285 mutant showed very low tetracycline resistance. (ABSTRACT TRUNCATED AT 250 WORDS)


Input: Tumor necrosis factor alpha, the cytokine that participates in the autocrine growth control of hairy cell leukemia has strong bone resorptive properties.

Tumor necrosis factor alpha


Input: (iv) Although UCRBP has been previously shown to act as a transcriptional repressor, we show here that UCRBP can also act as a positive transactivator of a reporter driven by UCR elements when used in co-transfection assays.

UCRBP

UCRBP


Input: The sequence of monkey opsin closely resembles the human sequence at the nucleotide and the amino acid levels, with the latter having only 7 differences out of 348 residues.

monkey opsin


Input: One complex appears to be ubiquitous but enriched in lymphoid cells and represents the binding of a potentially novel factor with an apparent molecular mass of approximately 50 kDa.


Input: Chem.


Input: Conversely, activation of Oct-3/4 promoter by RAR: RXR heterodimers was completely abolished by EAR-3/COUP-TFI and by ARP-1/COUP-TFII.

Oct-3/4 promoter

RAR

RXR heterodimers

COUP-TFI

COUP-TFII


Input: These results demonstrate that EKLF provides a crucial transactivation function for globin expression and further reinforce the idea that EKLF is an important regulator of CACCC element-directed transcription in erythroid cells.

EKLF

globin

EKLF


Input: Using a battery of I kappa B alpha mutants, we show that (i) a dimer binds a single I kappa B alpha molecule, (ii) the acidic C-terminal region of I kappa B alpha is not required for protein-protein binding and does not mask the nuclear localization signal of the dimer, (iii) the same C-terminal region is required for inhibition of DNA binding, and (iv) this inhibition may be accomplished by direct interaction between the PEST-like region and the DNA-binding region of one of the subunits of the dimer.

I kappa B alpha mutants

I kappa B alpha molecule

I kappa B alpha


Input: The negative regulatory activity of the N-terminal domain was antagonized by a C-terminal segment of Pho81p supplied in trans.


Input: At different times of the surgical procedures (thorax opening and closure, period of cardiopulmonary bypass) 67 to 100% of the patients in group 1 had vancomycin concentrations in the studied tissues above the MIC 90 for Staphylococcus aureus (1 microgram/g) and Staphylococcus epidermidis (2 micrograms/g).


Input: On-line angioscopic images of tissue flaps floating in the lumen, recent or structured thrombi, artery wall dissections, plaque ruptures, deep fissurations and sub-intimal haemorrhages demonstrate, in live colour, the pathophysiological mechanisms of coronary artery stenosis.


Input: The enhanced cysteine formation in a pCSK4F plant responding to sulfite was also observed in leaf discs.


Input: Each type was divided into two subgroups on the basis of whether the body and tail of the pancreas showed intense fatty replacement (type a = negative for intense fatty replacement, type b = positive for intense fatty replacement).


Input: A new hypothesis on mechanisms for inhibiting catalytic subunits by gamma-subunits and activation of a holoenzyme by transducin


Input: Binding of SSP to the stage selector element (SSE) in the proximal gamma-globin promoter is integral to the competitive silencing of a linked beta-promoter in embryonic/fetal stage erythroleukemia (K562) cells.

SSP

stage selector element

SSE

gamma-globin promoter

beta-promoter


Input: This failure to execute regulated G1/S arrest is correlated with enhanced thermosensitivity of colony-forming ability.


Input: Mutations that alter photoreceptor cell structure and development were isolated that fail to complement these deletions.


Input: It is possible that the telomeres of the two nuclei have different functions.


Input: The marker orders from the genetic and RH maps were consistent.


Input: Integrated mapping analysis of the Werner syndrome region of chromosome 8.


Input: The region between DXS52 and Factor VIII gene in the human Xq28 chromosomal band contains a G + C-rich isochore to which many genes have been mapped.

Factor VIII gene


Input: Haplotype mapping and sequence analysis of the mouse Nramp gene predict susceptibility to infection with intracellular parasites.

Nramp gene


Input: This utilization of an intronic polyadenylation site without alternative exon usage is comparable to the mechanism whereby both secreted and membrane-bound forms of the immunoglobulin mu heavy chain are made from a single genetic locus.

immunoglobulin mu heavy chain


Input: To further our knowledge about the systemic humoral immune system response to weak hapten-syngeneic or allogeneic protein conjugates (corrosion and wear products of metallic orthopedic devices), a sensitive enzyme-linked immunosorbent assay (ELISA) method for testing for antibody (humoral immunity) to metals was developed.


Input: In contrast, peak filling rate (PFR), normalized to end diastolic volume (EDV), or stroke volume (SV), or expressed as the ratio of PFR-to-PER was reduced (p < 0. 01), time to PFR (TPFR) was prolonged (p < 0. 01), and echocardiographic left ventricular mass index was higher (p < 0. 001) in patients with acromegaly compared to normals.


Input: A genetic complementation system was developed in which tobacco etch virus (TEV) polymerase (NIb)-expressing transgenic plants or protoplasts were inoculated with NIb-defective TEV mutants.

tobacco etch virus (TEV) polymerase

NIb

NIb

TEV mutants


Input: Nucleotide sequence and transcriptional analysis of the DNA polymerase gene of Bombyx mori nuclear polyhedrosis virus.

DNA polymerase gene of Bombyx mori nuclear polyhedrosis virus


Input: Comparison of the genomes of PMTV, BNYVV, and SBWMV shows that furoviruses exhibit considerable heterogeneity in genome organization.


Input: The drug sensitivity was 100% for vancomycin (VCM), 30% for imipenam (IMP), 31% for minomycin (MINO), 31% for amikacin (AMK), and 7% for fosfomycin (FOM).


Input: Deglycosylation with endoglycosidase H showed that the mutant receptors had mainly high-mannose oligosaccharide chains.

endoglycosidase H


Input: Dietary supplement with fish oil and related n-3 EFAs has been used to study their antihypertensive property in animals and humans with borderline and essential hypertension.


Input: The HSD3B1 and HSD3B2 genes encoding the types I and II 3 beta-HSD isoenzymes, respectively, have been previously assigned by in situ hybridization to the chromosome 1p13. 1 region.

HSD3B2 genes

types I and II 3 beta-HSD isoenzymes


Input: Therefore the prevalences of total diabetes and GDM were 1. 19% and 0. 56%, respectively.


Input: Insulin-stimulated glucose transport in adipocytes is mediated by the insulin receptor.

Insulin

insulin receptor


Input: After selection and conversion to adipocytes, the level of EGFR expression was retained in infectant adipocytes (150, 000 and 250, 000/cell, respectively), but not in the parental 3T3-L1 adipocytes (< 5000/cell).

EGFR


Input: Intron-exon structure of the porcine I kappa B alpha-encoding gene.

porcine I kappa B alpha-encoding gene


Input: Fraction 2 contains 1, 25 (OH) 2-vitamin D3, vitamin D3, 25 (OH)-vitamin D3 and 1, 24, 25 (OH) 3-vitamin D3.


Input: The kallistatin gene was localized by in situ hybridization to human chromosome 14q31-q32. 1, close to the serpin genes encoding alpha 1-antichymotrypsin, protein C inhibitor, alpha 1-antitrypsin, and corticosteroid-binding globulin.

kallistatin gene

serpin genes

alpha 1-antichymotrypsin

protein C inhibitor

alpha 1-antitrypsin

corticosteroid-binding globulin


Input: The locus encoding the XD gene (designated Xd) was mapped to the distal part of mouse chromosome 17 by haplotype analysis of 114 interspecific backcross mice.

XD gene

Xd


Input: Some studies of exercise have associated beta-endorphin release with increased exertion levels, but other evidence suggests that acidosis may stimulate the release of beta-endorphin.

beta-endorphin

beta-endorphin


Input: An interatrial communication mitigates the impairment of LV function after an acute and sustained drop of intrathoracic pressure.


Input: The characteristics of the VirD1/VirD2-mediated cleavage reaction strongly resemble those observed with relaxosomes of IncP plasmids involved in initiation of transfer DNA replication during bacterial conjugation.


Input: Isoelectric focusing of tryptic peptides generated from MHC-B phosphorylated with cdc2 kinase revealed one major phosphopeptide that was purified by reverse-phase high performance liquid chromatography and sequenced.

MHC-B

cdc2 kinase


Input: The deduced protein sequence was 88% homologous to that of hNUC I, isolated from human osteosarcoma cells.

hNUC I


Input: A comparison of the Flavobacterium glycosylasparaginase with a mammalian glycosylasparaginase revealed 30% structural identity and 60% overall similarity between the prokaryotic and eukaryotic forms of the enzyme.

glycosylasparaginase

glycosylasparaginase


Input: Dissociation and complexation of the fluoroquinolone antimicrobials--an update.


Input: Superoxide dismutase (SOD) activity decreased significantly in sperm subjected to direct electric current in comparison to the control or the sample incubated with electrolyzed medium.

Superoxide dismutase

SOD


Input: These studies indicate that in vitro and in vivo electrical stimulation generate reactive oxygen species and affect SOD activity, which in part are responsible for decreased sperm motion and viability.

SOD


Input: Sex selection via albumin columns: 20 years of results.

albumin


Input: They also reported that E mu pim-1 transgenic mice show greatly accelerated lymphoma development when infected with wild-type M-MuLV at birth.

E mu pim-1


Input: Comparison of human and murine blk sequences indicated that they share 86% amino acid identity, the most conserved region being the catalytic domain (93% identity).

human and murine blk sequences


Input: The effect of ethanol on human sensorimotor reactivity was assessed by examining the acoustic startle response.


Input: Digitalis glycosides or beta-receptor antagonists are not helpful in the therapy of this form of atrial fibrillation whereas class I antiarrhythmic drugs have been shown to be more effective.

beta-receptor


Input: Atrial fibrillation and the autonomic nervous system


Input: VIII in doses 2-3 times higher than usually used in haemophiliacs without inhibitor were successful.


Input: A reduction of the aspartate aminotransferase activity was observed from 800 mg/kg b. w./d onwards.

aspartate aminotransferase


Input: Thus, these studies indicate that the 104-kDa isoform is required for normal proliferation of female germline cells and perhaps for oocyte differentiation.


Input: Physical analysis maps SAL6 to chromosome XVI between TPK2 and spt14.


Input: The newly devised DCT method yields reliable data in measuring TBF.


Input: Removal of PDMP from the cell medium resulted in reversal of the cell cycle changes, with cells re-entering the S phase.


Input: Rho GDP/GTP exchange inhibitor, Rho GDI, comigrated with Rac2 and RhoA, but not Rac1.

Rho GDP/GTP exchange inhibitor

Rho GDI

RhoA


Input: Schnell, J.


Input: Encapsidation of poliovirus replicons encoding the complete human immunodeficiency virus type 1 gag gene by using a complementation system which provides the P1 capsid protein in trans.

human immunodeficiency virus type 1 gag gene

P1 capsid protein


Input: The requirement of PilE in pilus biogenesis was confirmed by demonstrating that chromosomal pilE insertion mutants were pilus-and twitching-motility deficient.

PilE

chromosomal pilE insertion mutants


Input: The pilE gene product of Pseudomonas aeruginosa, required for pilus biogenesis, shares amino acid sequence identity with the N-termini of type 4 prepilin proteins.

pilE gene product of Pseudomonas aeruginosa

type 4 prepilin proteins


Input: Because of the functional conservation of cell cycle control elements, the expression of a vertebrate wee1 or mik1 homolog would be expected to rescue such lethal mutations in yeast.

vertebrate wee1

mik1 homolog


Input: The expression of this clone in a wee1/mik1-deficient mutant causes an elongated cell phenotype under non-permissive growth conditions.


Input: These data indicate that phosphorylation of M protein at the major in vivo sites is not essential for virus assembly.

M protein


Input: Near a third (31. 6%) of Insulin Dependent and a third (33. 41%) for Non Insulin Dependent were of D, F, H White' s Class.

Insulin

Insulin


Input: The activity of 6-fluoroquinolones and their nonfluorinated derivatives is compared in general.


Input: As the half-life of the compound did never exceed 8-9 h, the data do not support any change of pidotimod administration schedule (every 24-12 h).


Input: The MAP kinase cascade is highly conserved in all eukaryotes and involved in numerous cellular responses.

MAP kinase


Input: A comparative study by holographic interferometry of ten porcine bioprosthetic valves (seven Carpentier-Edwards SAV, two BioImplant and one Valcor) with five human aortic valves before and after glutaraldehyde treatment is presented.


Input: No serious side effects were observed.


Input: This region constitutes the DNA-binding domain with basic-helix-loop-helix and leucine-zipper motifs, features common to the myc-related transcription factor family.

myc-related transcription factor family


Input: The mean jitter and the fiber density did not change significantly from day 0 (30. 1 +/-3. 6 microseconds; 1. 4 +/-0. 07) to day 30 (34. 5 +/-2. 7 microseconds; 1. 6 +/-0. 13).


Input: Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product.

cyclin D

Cdk

Rb


Input: Recombinant human serum albumin (rHSA) produced by cultured fermentation has been prepared in the form of microcapsules nominally 3-5 microns in diameter and radiolabelled with technetium-99m following reduction with stannous chloride.

Recombinant human serum albumin

rHSA


Input: We have measured the release of interleukin-1 beta (IL-1) and tumour necrosis factor-alpha (TNF) by unstimulated monocytes and monocytes stimulated with lipopolysaccharide (LPS) isolated from the peripheral blood of two patients with acute poststreptococcal glomerulonephritis (AGN) and 16 healthy controls.

interleukin-1 beta

tumour necrosis factor-alpha

TNF


Input: Such an intervention may be of considerable use for the treatment of angiogenesis-dependent diseases involving FGF-2.


Input: UV cross-linking experiments show that TEP has an apparent molecular mass of approximately 65 kDa.

TEP


Input: Alternatively, loss-of-function alleles of genes that inhibit cAPK lead to the inability to undergo sexual differentiation.

cAPK


Input: One member of this family, RFX1, is a transcription factor for a variety of viral and cellular genes.


Input: This mutant was identified by screening with a TGF-beta-inducible vector a series of mink lung epithelial cell clones that have normal TGF-beta binding activity but have lost antiproliferative and transcriptional responses to TGF-beta.

TGF-beta

TGF-beta

TGF-beta


Input: Cloning by complementation and subsequent physical and genetic analysis revealed that it maps to RAF1.


Input: In the presence of inositol and choline (repressing), the product of the OPI1 gene represses transcription dictated by the UASINO element.

OPI1 gene


Input: By treating monkey COS cells with oligonucleotides linked to psoralen, we have generated targeted mutations in a simian virus 40 (SV40) vector contained within the cells via intracellular triple helix formation.


Input: The interleukin 2 receptor alpha-chain (IL-2R alpha) gene is rapidly and potently induced in T cells in response to mitogenic stimuli.

interleukin 2 receptor alpha-chain

IL-2R alpha


Input: The Wilms' tumour suppressor protein (WT1) is a putative transcriptional regulatory protein with four zinc fingers, the last three of which have extensive sequence homology to the early growth response-1 (EGR-1) protein.

Wilms' tumour suppressor protein

early growth response-1


Input: OBJECTIVES: 1) to determine serum ACE activity in patients with COPD treated with and without continuous ambulatory oxygen therapy (CAOT); 2) to verify whether there is a correlation between ACE and any hematological, spirometric or gasometric parameter.

serum ACE

ACE


Input: In order to infer shape from contour, the human visual system must selectively integrate fragments projecting from a common object while keeping fragments from different objects separate.


Input: Among 9 group I patients with a positive result on head-up tilt-table testing and no evidence of structural heart disease (mean follow-up 4. 3 years), 7 are without further episodes of syncope; 3 have discontinued medication and 5 have resumed at least limited exercise.


Input: Constructs designed and expressed were E2L1 (1-98), E2L1. H1 (1-128), E2L2 (120-233), E2H1. L2 (98-233), and E2L1. H1. L2 (1-233), where numbers in parentheses give the amino acid sequence for the portions of the E2 component incorporated into a construct.

E2L1 (1-98)

E2L1. H1 (1-128)

E2L2 (120-233)

E2H1. L2 (98-233)

E2L1. H1. L2 (1-233)


Input: Thus, we have produced lipoyl domain constructs that can be employed in sorting the specific roles of E2L1 and E2L2 in facilitating catalytic and regulatory processes.


Input: METHODS: Ten influenza A (H3N2) viruses isolated during the outbreaks were examined for resistance to amantadine and rimantadine by means of an enzyme immunoassay and by sequencing of the viral nucleic acid that encodes the transmembrane domain of the M2 protein.

M2 protein


Input: The first contains ATF/CRE and TBP/TATA sequence motifs within an 87-bp region.

ATF

TBP


Input: Gene expression occurs in a circadian rhythm and induced by light in leaves of dark-adapted plants.


Input: Our results suggested that the hexamer and the octamer motifs may play important role (s) in regulation of replication-dependent but not of replication-independent expression of the wheat histone H3 gene.

wheat histone H3 gene


Input: The tissue-specific expression of DP family members suggests that the combination of DP/E2F heterodimers that constitute DRTF1/E2F is influenced by the phenotype of the cell.

DP family members

DP


Input: In a second experiment involving an 18-h lung clearance assay, we used the mAb 3. 2. 3 to deplete rats of LGL/NK cells with the following rationale: if LGL/NK cells are necessary to mediate an event, then in their absence, that event should not occur.

mAb 3. 2. 3


Input: Treatment of recurrent FSGS has included high-dose steroids, high-dose cyclosporine (CSA), plasmapheresis, and ACE inhibitors with mixed results.

ACE


Input: Our results concluded that 1) the two inhibin/activin beta B-subunit mRNAs were transcribed from different initiation sites; 2) both promoters may be controlled by up-stream negative regulatory elements; and 3) neither of these promoters is responsive to cAMP and/or phorbol esters under the conditions employed.

inhibin

activin


Input: Promoter region of the transcriptional unit for human alpha 1-chimaerin, a neuron-specific GTPase-activating protein for p21rac. alpha 1-chimaerin is a neuron-specific GTPase-activating protein for p21rac, a protein involved in morphological events.

human alpha 1-chimaerin

neuron-specific GTPase-activating protein

alpha 1-chimaerin

neuron-specific GTPase-activating protein


Input: Upstream from the transcription start point (tsp), a nucleotide sequence highly homologous to the consensus sequence motif for the sigma 35-recognized promoters was found.

consensus sequence motif for the sigma 35-recognized promoters


Input: In this paper, an analysis of the dynamics in the closing phase of the occluder of a mechanical monoleaflet heart valve prosthesis is presented.


Input: During ISO + AT infusion, abdominal fat blood flow was still significantly increased as compared with control values in lean and obese subjects.


Input: When expressed per kilogram body weight, mean GIT increased in the dF group from 0. 14% to 0. 16% above RMR, with a significant decrease from 0. 15% to 0. 13% in the P group.


Input: In nucleus ventralis anterior thalami-nucleus ventralis lateralis thalami neurons with an inhibitory input from nucleus entopeduncularis, a shortening of inhibition from 17. 5 +/-3. 6 to 9. 1 +/-1. 8 ms (P < 0. 05) under the haloperidol influence was evident.


Input: However, inclusion of the neighboring CGGAAR motifs from the ICP4 promoter, which bind factors GABP alpha and beta, results in a strong synergistic activation.

ICP4 promoter

GABP alpha and beta


Input: This finding represents both a potentially important mechanism by which HPV gene expression can be regulated and an interesting model for the study of transcriptional cooperativity.


Input: Using this method, VLPs were obtained in quantities sufficient for further characterization.


Input: Analysis of the sequence upstream of this initiation codon reveals the presence of a promotor sequence.


Input: SUP46 is implicated in translation fidelity and encodes the ribosomal protein S13.

ribosomal protein S13


Input: To explore the functional relationship between c-fos and Rb, a eukaryotic expression plasmid was constructed containing the c-fos gene under control of the SV40 promoter complex.

c-fos

Rb

c-fos gene

SV40 promoter


Input: The high degree of sequence identity (96%) between hydrolase B and C, particularly in the 3' untranslated region, suggests that the genes encoding these two carboxylesterases evolved by duplication and divergence of a common ancestral gene.

hydrolase B and C

carboxylesterases


Input: The regions of the tooth fracture are determined.


Input: Secondary pancreatic involvement of mycosis fungoides detected by a clinically palpable mass.


Input: The NR2 hybrid is a powerful tool for the mapping of new probes of this region, as well as for obtaining new informative probes specific for the deletion by subtractive cloning of the region.


Input: TDEYA at doses of 200 to 500 mg/kg significantly suppressed xanthine oxidase (XO) activity in the stomach tissue following its oral administration.

xanthine oxidase

XO


Input: Like humans, the PITSLRE PK genes in chickens must be closely linked, based on fluorescent in situ hybridization (FISH) localization of these genes to a single chicken microchromosome.

PITSLRE PK genes in chickens


Input: Here, we report the characterization of an alternatively processed form of AFAP-110 that encodes an additional 258 base pair (bp) of open reading frame.


Input: Expression of class IV ADH mRNA was detected in human stomach but not liver.

class IV ADH mRNA


Input: In ICE gamma, most of the propeptide (amino acids 20-112) is deleted, which suggests that it may function as a catalyst for ICE autoprocessing in vivo.

ICE gamma

ICE


Input: Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain.

epidermal growth factor receptors

tyrosine kinase domain


Input: It is now recognized that essentially all eukaryotic and prokaryotic genes whose 5'-flanking regions are known and that encode barbiturate-inducible proteins contain the Barbie box element.


Input: Mutation of the P450BM-3 Barbie box significantly increased the expression of both P450BM-3 and Bm3P1 (another small gene located upstream of the P450BM-3 gene that encodes a second putative regulatory protein) in response to pentobarbital induction but left the basal levels unaffected.

P450BM-3 Barbie box

P450BM-3 gene


Input: A potential outcome of these biochemical effects may include the limited responsiveness of infected T cells to antigenic stimulation observed during HIV-1 infection.


Input: The full protocol was completed by 33 patients (45% of original cohort).


Input: In addition, we found that cell-specific suppression of RA-stimulated zif268 gene expression can be attributed to a 29 base pair nucleotide sequence, located downstream of the RA-responsive region in the zif268 gene.

zif268 gene

zif268 gene


Input: We show that CBF-A and CBF-C interact with each other to form a CBF-A-CBF-C complex and that CBF-B does not interact with CBF-A or CBF-C individually but that it associates with the CBF-A-CBF-C complex.

CBF-A

CBF-C

CBF-A

CBF-C

CBF-B

CBF-A

CBF-C

CBF-A

CBF-C


Input: In the first, homologous sequences were deleted from a mouse enhancer, resulting in a tissue-specific loss of activity when assayed in transgenic mice.


Input: OKT3 prophylaxis improves long-term renal graft survival in high-risk patients as compared to cyclosporine: combined results from the prospective, randomized Belgian and US studies.


Input: The major PKC beta transcription initiation site was identified by primer extension and S1 nuclease protection.

PKC beta

S1 nuclease


Input: In the course of a study of low dose X-rays effects, we found that male ICR white Swiss mice showed remarkable suppression of mounting behavior after whole body irradiation by 5 to 15 cGy X-rays.


Input: A quantitative analysis of the diffraction intensity as function of the accumulated electron dose suggests the possibility of recording up to 250 diffraction patterns with 3. 5 A resolution from a single crotoxin complex crystal 128 A thick.


Input: Supplementary Phase Contraste RSE (" Rapid Sequential Excitation ") sequences were carried out in 29 patients.


Input: In yeast, the products of the UPF1 and UPF3 genes are required for this decay pathway, and in this report we focus on the identification and characterization of additional factors required for rapid decay of nonsense-containing mRNAs.

UPF3 genes


Input: Mutations in UPF1 lead to the selective stabilization of mRNAs containing early nonsense mutations without affecting the decay rates of most other mRNAs.


Input: A DNA fragment encoding the DNA-binding domain (amino acids 1-60) of the Escherichia coli fru transcriptional regulator was cloned into the pGEX-KT vector and expressed in frame with the fused gene encoding glutathione S-transferase.

Escherichia coli fru transcriptional regulator

glutathione S-transferase


Input: 0. 61 +/-0. 04).


Input: Several nuclear factors that interact with sequences in the 5' flanking region of the mouse tyrosinase gene were identified using band shift and methylation interference assays.

mouse tyrosinase gene


Input: With a population of 853 million there should be 51, 204 patients with hemophilia A in India assuming a prevalence of 6/100, 000 population.


Input: When combined with serum ferritin and hemoglobin determinations, the serum transferrin receptor assay is a valuable addition in epidemiologic surveys because it provides a quantitative measure of functional iron deficiency and it distinguishes true IDA from the anemia of chronic disease.

ferritin

hemoglobin

transferrin receptor


Input: Since 1990 the University Hospital of Tromso has provided local hospitals in northern Norway with a remote frozen section service and with access to video conferences for the review of microscopic findings and for the discussion of major diagnostic issues.


Input: Current status of telepathology.


Input: PMEK1 displays 96 and 80% identity respectively with the tobacco NTF3 and Arabidopsis ATMPK1 kinases, and only 50% to the more distantly related plant MAP kinase MsERK1 from alfalfa.

tobacco NTF3

Arabidopsis ATMPK1 kinases


Input: Translation of the coding segment, which was designated MsPRP2, suggested it encodes a chimeric 40, 569 Da cell wall protein with an amino-terminal signal sequence, a repetitive proline-rich sequence, and a cysteine-rich carboxyl-terminal sequence homologous to nonspecific lipid transfer proteins.


Input: The presence of type I hypersensitivity in a subgroup of aspergillomas suggests an immunoallergic component to this disease which could contribute to a chronic inflammatory response to Aspergillus in some aspergillomas.


Input: This concept is supported by the identification of RH-like genes in non human primates.

RH-like genes


Input: With steady illumination, outer retinal (photoreceptor) QO2 decreased to 1. 4 +/-0. 9 ml O2/(100 g. min), but inner retinal QO2 remained unchanged at 3. 7 +/-1. 5 ml O2/(100 g. min) (5 cats).


Input: We have screened the mouse cDNA library of an MIN6 cell line, derived from pancreatic beta cells, for its novel isoform and have identified a cDNA encoding a 593-amino acid protein having 63, 53, and 30% identity with munc-18/n-Sec1/rbSec1, Caenorhabditis elegans unc18, and Saccharomyces cerevisiae Sec1p, respectively.

Caenorhabditis elegans unc18

Saccharomyces cerevisiae Sec1p


Input: The catenins bind to APC and E-cadherin in a similar fashion, but APC and E-cadherin do not associate with each other either in the presence or absence of catenins.

catenins

APC

E-cadherin

APC

E-cadherin

catenins


Input: However, addition of core DNA polymerase III to preinitiation complex, fully reconstituting holoenzyme resulted in replacement of gamma by alpha at the primer terminus.

core DNA polymerase III


Input: Computerized detection of abnormal asymmetry in digital chest radiographs.


Input: These results suggest that gluconeogenic genes are derepressed upon binding of Cat8p, whose synthesis depends on the release of Cat4p (Mig1p) from the CAT8 promoter.

CAT8 promoter


Input: We show here that the binding of C1F in vitro is sensitive to the concentration of calcium ions.


Input: Survival after development of symptomatic infection (P-2) did not differ by transmission mode.


Input: These data suggest that the function of the DS2 may be the protection of the nuclear DNA from desiccation.


Input: Glomerular hemodynamics during abortion induced by RU 486 and sepsis in rats.


Input: The aim of this retrospective study was to demonstrate that in certain cases of expulsive choroidal hemorrhage (ECH) anatomical success and useful vision can be obtained with repeated vitreoretinal surgery.


Input: The function of the C-terminal tail in telomere maintenance is not mediated through the RAP1 interacting factor RIF1: rap1 alleles defective in both the C-terminal tail and RIF1 interaction domains have additive effects on telomere length.

RAP1 interacting factor RIF1

rap1 alleles

RIF1 interaction domains


Input: The contribution of skin flow to the changes in 760-800 nm absorption was investigated by simultaneous measurement of skin flow by laser flow Doppler and NIR recordings during hot water immersion.


Input: Proteins immunoprecipitated from lysates of control-and VEGF-stimulated BAEC with antisera to phospholipase C-gamma (PLC-gamma) were fractionated by SDS-polyacrylamide gel electrophoresis and transferred to Immobilon-P.

VEGF

phospholipase C-gamma

PLC-gamma


Input: Alternatively processed isoforms of cellular nucleic acid-binding protein interact with a suppressor region of the human beta-myosin heavy chain gene.

cellular nucleic acid-binding protein

human beta-myosin heavy chain gene


Input: Involvement of early growth response factor Egr-1 in apolipoprotein AI gene transcription.

early growth response factor Egr-1

apolipoprotein AI gene


Input: The wild-type and altered forms of the F protein were expressed in BHK-21 and HeLa T4 cells by use of the recombinant vaccinia virus-encoding T7 polymerase system.

F protein

recombinant vaccinia virus-encoding T7 polymerase


Input: Erythrocyte delta-aminolevulinic acid dehydratase (ALAD) activity, erythrocyte zinc protoporphyrin (ZPP)/heme ratio, and urinary coproporphyrin (UC) concentration have been employed as biological indicators of moderate-to high-level lead exposure, corresponding to blood levels in excess of 50 micrograms/dl, in human subjects.

Erythrocyte delta-aminolevulinic acid dehydratase

ALAD


Input: The relative risk of graft loss after conversion to azathioprine compared with graft loss after conversion to azathioprine compared with cyclosporin maintenance was 0. 71 (0. 37-1. 38) and the relative risk of patient death was 0. 57 (0. 23-1. 41).


Input: The " tobacco issue ".


Input: The effect of the Ca entry blocker nitrendipine, the antioxidant superoxide dismutase (SOD), and a combination of nitrendipine and superoxide dismutase on postischemic renal function was studied in four groups (n = 24) of rats.

superoxide dismutase

SOD

superoxide dismutase


Input: PURPOSE: The aim of this study was to evaluate the bony anchorage of a new implant (orderly wired surface effect with alloy Ti Al Va and ordered pores of 488 mu).


Input: To determine whether food and/or water in the gastrointestinal tract affects restitution of blood volume and plasma protein after hemorrhage, fed and 24-h-fasted awake rats received a 20 ml. kg-1 x 3 min-1 hemorrhage, and restitution of blood volume was measured by Evans blue dye and dilution of hematocrit.


Input: Cooperative dimerization of paired class homeo domains on DNA.

paired


Input: We took advantage of the high degree of aa sequence homology between DAHPSs from several species to isolate ARO3 homologues from the pathogenic yeast Candida albicans.

DAHPSs

ARO3 homologues


Input: In this study, we demonstrate that BOX DNA enhances transcription from the thymidine kinase (TK) promoter in various EC cells.

thymidine kinase

TK


Input: Deletion analyses of the construct revealed that the transcription of BOXF1 gene is regulated by BOX DNA, preferentially in undifferentiated EC cells versus differentiated cells.

BOXF1 gene


Input: The presence of an unusual transcript possessing IVS2C beta 1 at the 5' terminus suggests that cleavage of its splice acceptor is inefficient or negatively regulated.

IVS2C beta 1


Input: During chronic treatment, when plasma concentrations fluctuated between 23. 5 ng. ml-1 at 8 h and 14 ng. ml-1 at 24 h post-dosing, ST segment depression at an individually comparable workload was significantly decreased by 28% compared with placebo (P < 0. 005) at both points in time.


Input: Results from in vitro transcription-translation analysis and maxicell experiments suggested that the 447-bp ORF was the one being actively expressed.


Input: Preliminary experiments demonstrated that it was possible to produce fasD mutants, whose products remain functional for fimbrial export and assembly.

fasD mutants


Input: Evoked electromyographic response to indirect supramaximal stimulation at 1 Hz was monitored in ten adult goats under thiopentone-halothane anaesthesia.


Input: 313, 98-102).


Input: Group 6 was given physostigmine, 0. 1 mg/kg i. v., known to inhibit cholinesterase degradation, 5 min before bupivacaine administration, and Group 7 received a combination of physostigmine pretreatment and electrical vagal stimulation.

cholinesterase


Input: To examine the possibility that LNNB performance of the schizophrenic groups may have been related to neuroleptic medication, analyses were completed on the relationship between medication levels and LNNB scores.


Input: ISIS 5 possibilities.


Input: The use of specific antibodies allowed the identification of at least RAR beta in some of the DNA-protein complexes, although the four sequences bind single RARs transfected in COS cells much less efficiently, or not at all, when compared to a canonical RAR responsive element.

RAR beta

RARs

RAR responsive element


Input: The present treatment strategy in progressive disorders is mainly based on the complementary effect of intensive radiochemotherapy, autologous stem-cell transplantation and the rational use of cytokines, mostly colony-stimulating factors.

colony-stimulating factors


Input: Our study cohorts consisted of 15 patients who received SC rIL-2 at doses of 4. 8-14. 4 million IU/m2/day on 5 days per week for a total of 8 weeks, 20 patients who received rIFN-alpha 2b at 3. 0-6. 0 million U/m2/day thrice weekly for a total of 6 weeks, and 72 patients who were given SC rIFN-alpha 2b at 6. 0 million U/m2/day thrice weekly plus SC rIL-2 at 14. 4-18. 0 million IU/m2/day on days 1 and 2, followed by 4. 8 million IU/m2/day, 5 days per week for 6 consecutive weeks.

rIFN-alpha 2b

rIFN-alpha 2b


Input: At the MTD (8 mg/m2/day), the dose-limiting toxicity of this agent is myelosuppression.


Input: Mitogen-induced lymphocyte proliferation was diminished.


Input: A decanucleotide promoter sequence homologous to those found in humans and mice was located in the 5' untranslated region of one horse gene.


Input: Some of these targets were reported to code for molecules involved in cell-cell interactions, whereas no relationship has yet been demonstrated between Hox genes and other transcription factors involved in determining and/or maintaining tissue specificity.

Hox genes


Input: HER2 overexpressing cells showed a single prominent DNase I hypersensitive site near a conserved and hitherto unrecognized ets response element (GAGGAA), located 38 bases down-stream from the CAAT box and directly 5' of the TATA box in the human HER2 promoter.

DNase I

ets

human HER2 promoter


Input: Gel-shift assays with nuclear extracts and oligonucleotide sequences spanning the 0. 125-kb promoter region detected an ETS-immunoreactive complex, present most abundantly in cells overexpressing HER2, whose high-affinity binding depended on the GAGGAA response element.

ETS


Input: Comparison of cDNA sequences revealed that the two mRNA species arise as a result of alternate use of poly (A)-addition sites.


Input: The gene for the RNA-dependent eIF-2 alpha protein kinase (PKR) was isolated from mouse genomic DNA and characterized.

RNA-dependent eIF-2 alpha protein kinase

PKR


Input: High-frequency electrical stimulation in the hippocampus leads to an increase in synaptic efficacy that lasts for many hours.


Input: Similar to the mouse gene, the 5' flanking region of human CD79 alpha lacks a TATA box; however, unlike mouse CD79 alpha, a classical octamer motif could not be identified in the human gene.

human CD79 alpha

mouse CD79 alpha


Input: Detailed molecular organization of the coding and upstream regulatory regions of the murine homeodomain-containing gene, Msx-1, is reported.

homeodomain-containing gene


Input: We report here the cloning of the human goosecoid gene (GSC) from a genomic library and the sequence of its encoded protein.

human goosecoid gene

GSC


Input: This virus is not merely a South African strain of passion fruit woodiness virus (PWV): the deduced CP sequence is only distantly related to CPs of other sequenced strains of PWV, although it is part of a distinct subgroup of potyviruses related to PWV.

CP sequence

CPs


Input: The ratio of the activity of arogenate dehydrogenase to that of prephenate dehydrogenase (approximately 3: 1) remained constant throughout purification, and the two activities were therefore inseparable.

arogenate dehydrogenase

prephenate dehydrogenase


Input: A leucine zipper domain of the suppressor of Hairy-wing protein mediates its repressive effect on enhancer function.

suppressor of Hairy-wing protein


Input: It is concluded that CT should be routinely employed in patients with N1-N3 neck disease to determine the proper electron-energy prescription.


Input: The predicted DNA-binding, zinc finger domain protein sequence was strictly conserved.

zinc finger domain protein


Input: 60 patients were entered into a randomised study comparing vindesine (3 mg/m2/week) plus interferon-alpha 2b (6 U/m2 3 times per week) to vindesine alone or to interferon alone for the treatment of metastatic malignant melanoma.

interferon-alpha 2b

interferon


Input: BACKGROUND: We conducted a phase I study with MDL 73, 147EF, a new 5 hydroxytryptamine 3 (5-HT3) receptor antagonist, in 25 patients requiring emetogenic chemotherapy.

5 hydroxytryptamine 3 (5-HT3) receptor


Input: In the presence of the in vivo reducing system (thioredoxin, thioredoxin reductase, and NADPH), however, each of these mutants catalyzed the formation of only 0. 6-0. 8 dCTPs per mole of enzyme.

thioredoxin

thioredoxin reductase


Input: These genetic alterations do not affect synthesis of the major c-myc protein, p64, which is initiated from the first AUG codon in exon 2.

c-myc protein


Input: In addition, both the exon 1-and exon 2-initiated forms of the c-Myc protein stimulated transcription of a Myc/Max-responsive reporter construct to a similar level.

c-Myc protein

Myc

Max


Input: Biological activities of hematopoietic growth factors that lead to future clinical application.

hematopoietic growth factors


Input: Expression is exclusively limited to the CNS at this and later stages.


Input: Disruption of any one of the four genes encoding the newly identified SRP proteins results in slow cell growth and inefficient protein translocation across the ER membrane.

SRP proteins


Input: Genetic alterations in elements of normal signal transduction mechanisms are known to be oncogenic events often resulting in aberrant activation of programs of gene transcription.


Input: The expression pattern of GL2, as demonstrated by in situ hybridization, indicated that the gene is expressed in trichome progenitor cells and at stages associated with trichome development.


Input: NOT4 interacts with NOT1 and NOT3 in the two-hybrid assay, and overexpression of NOT3 or NOT4 suppresses not1 and not2 mutations.


Input: Binding site selection using in vitro-synthesized proteins reveals that the ROR alpha 1 and ROR alpha 2 isoforms bind DNA as monomers to hormone response elements composed of a 6-bp AT-rich sequence preceding a half-site core motif PuGGTCA (RORE).

ROR alpha 1

ROR alpha 2 isoforms

RORE


Input: The p73pct1/p85cdc10 complex binds both in vitro and in vivo to MCB but not SCB or E2F sites.

MCB

SCB

E2F sites


Input: We show that the en stripes expand anteriorly in slp mutant embryos and that slp activity is an absolute requirement for maintenance of wg expression at the same time that wg transcription is dependent on hh.

en

slp

slp

wg

wg

hh


Input: The DNA sequence adjacent to the lacZ gene has been determined for 91 vegetative fusion genes whose products have been localized and for 43 meiotically induced fusions.

lacZ gene


Input: CMV hyperimmunoglobulin treatment (Cytotect, Biotest) was started (2 ml/kg bw on day 1 and 3, and 1 ml/kg on days 5, 7 and 9), which led to the eradication of the residual infiltrate and CMV-DNA in the myocardium.

hyperimmunoglobulin


Input: In eight groups of subjects operating various hand-held vibrating tools and aged from 30 to 59 years, the prevalence rates of vibration-induced white finger (VWF) and numbness, pain, or stiffness in the upper and lower extremities were investigated.


Input: DNA sequence analysis showed that the gene was 525 bp long and encoded a 175-amino-acid protein with a molecular weight of 19, 094 containing a 21-residue typical lipoprotein signal peptide and consensus prolipoprotein processing site.


Input: DNA sequence and functions of the actVI region of the actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3 (2).

actVI region

actinorhodin biosynthetic gene cluster of Streptomyces coelicolor A3 (2)


Input: (1992) Genomics 12, 58-62).


Input: A comparison of the predicted polypeptide sequence of the Drosophila protein with the equivalent subunits from mouse and yeast suggests that they are closely related and defines three conserved regions which are likely to be important for enzyme activity.


Input: Cytoplasmic dynein is a multisubunit, microtubule-dependent mechanochemical enzyme that has been proposed to function in a variety of intracellular movements, including minus-end-directed transport of organelles.

Cytoplasmic dynein


Input: Identification of the plakoglobin-binding domain in desmoglein and its role in plaque assembly and intermediate filament anchorage.

plakoglobin

desmoglein


Input: PATIENTS AND METHODS: One hundred eighty-four chemotherapy-naive patients receiving high-dose cisplatin (81 to 120 mg/m2) were randomized to receive one of four granisetron doses (5, 10, 20, or 40 micrograms/kg) administered before chemotherapy.


Input: Nine new naphthalene related compounds (I, IV, V, VII-XII) together with four known compounds (II, III, VI, XIII) were isolated from the root bark of Oroxylum indicum Vent.


Input: As shown previously, EBNA2 transactivates the promoters of the viral latent membrane proteins.

viral latent membrane proteins