Input: This protein-protein interaction does not require the simultaneous binding of Oct proteins to DNA, and high resolution footprinting of the Oct-DNA interaction reveals that binding of BOB. 1/OBF. 1 to Oct1 or Oct2 does not alter the interaction with DNA.

Oct proteins

Oct-DNA

BOB. 1

OBF. 1


Input: Together, our data suggest that the TR2 orphan receptor may be a master regulator in modulating the activation of two key HREs, RARE beta and CRBPIIp, involved in the retinoic acid signal transduction pathway.

TR2 orphan receptor


Input: Using a series of mutant proteins, we have characterized domains responsible for activation or repression.


Input: It is considered that the recurrent annular erythema is a specific skin manifestation of SjS with anti SS-A/SS-B antibodies.

anti SS-A

SS-B antibodies


Input: Competition needs to be better studied, since in Central America and Caribean islands this kind of study has favored the biological control of planorbid species.


Input: In this paper we describe properties of the cdc10-C4 mutant of the fission yeast Schizosaccharomyces pombe.


Input: TIEG expression in hFOB cells was highly induced by TGF-beta and bone morphogenetic protein-2 (BMP-2), with a moderate induction by epidermal growth factor (EGF), but no induction by other growth factors/cytokines was observed.

TIEG

TGF-beta

bone morphogenetic protein-2

epidermal growth factor

EGF


Input: The predicted protein products of ORFs N2417 and N2403 present similarities with domains from proteins of other organisms: the Candida maltosa cycloheximide-resistance protein, the human interleukin enhancer-binding factor (ILF-2).

ORFs N2417

cycloheximide-resistance protein

interleukin enhancer-binding factor


Input: In particular, the highly expressed ADH1 gene is represented in this database by no less than 20 EST sequences.

ADH1 gene


Input: Five families of Ashkenazi Jewish descent carried the 185delAG mutation and shared the same haplotype at eight polymorphic markers spanning approximately 850 kb at BRCA1.


Input: The subjects from the two regions with a higher pollution level had lower FVC and FEV1 values than those from the Viskovo region.


Input: PTP-S3 differs from PTP-S4 in having a deletion of 19 amino acids corresponding to exon E1.


Input: When differentiated G0-arrested leaf cells were induced to resume cell division by treatment with plant hormones, cycMs4 transcription was induced before the onset of DNA synthesis.


Input: A survey is given of the pharmacological backgrounds that are relevant for the drug treatment of essential hypertension in the elderly.


Input: Protein kinases play pivotal roles in the control of many cellular processes.


Input: Interestingly, internal and 5' deletions revealed tha the distal promoter was not required for full transcriptional activity and that the first 631 base pairs of WNT-5A harbored the strongest promoter activity.


Input: The protein kinase domains of LIMK1 and LIMK2 are unique in that they contain an unusual sequence motif Asp-Leu-Asn-Ser-His-Asn in subdomain VIB and a highly basic insert between subdomains VII and VIII.


Input: A human recombinant cDNA clone that encoded 253 amino acids residues of a zinc-finger protein (THZif-1) was cloned by screening a cDNA library prepared from human promyelocytic leukemia HL60 cells with synthetic oligodeoxynucleotide probes that corresponded to the amino acid sequences of tryptic peptides derived from the DNA-binding protein specific for the nuclease-hypersensitive element (NHE) of the human c-myc gene.

zinc-finger protein

nuclease-hypersensitive element

NHE

human c-myc gene


Input: Erythrocyte AA in FO + EPO-supplemented infants remained low and below breast-and placebo formula-fed levels.

EPO


Input: Taking into consideration weight and seasonal changes in bone mass, total (TBBMC) and regional body bone mineral content were measured in 38 women treated with GnRH agonists for 6 months for endometriosis or leiomyomata.

GnRH


Input: The encoded polypeptide is similar in sequence to the ABA-1 allergen of Ascaris, the gp15/400' ladder' protein of Brugia malayi, Brugia pahangi and Wuchereria bancrofti, and a 15-kDa antigen of Dirofilaria immitis.

ABA-1 allergen of Ascaris

gp15/400' ladder' protein of Brugia malayi, Brugia pahangi and Wuchereria bancrofti

15-kDa antigen of Dirofilaria immitis


Input: Spontaneous recovery occurs within 30 min to 2 hrs.


Input: DAF is a 70 kD glycoprotein containing complement regulatory short consensus repeats (SCRs); its gene is located in the regulation of complement activation (RCA) gene cluster on chromosome 1 and is about 40 kb in size.

DAF

regulation of complement activation

RCA


Input: There is no TATA box around the transcriptional start points (tsp), as determined by primer extension analysis.


Input: According to the investigation, the recent burst of pseudoterranovosis in this area can be attributed to the increased presence of sea lions, which proliferate in the Arctic region, then migrate to the northern Japan Sea and eat the intermediate host fish.


Input: In summary, the efficacies of adjuvant carboplatin and of abdominal radiotherapy seem to be identical.


Input: To identify some of the genes expressed in LPS-activated coelomocytes, we sequenced randomly chosen clones from a directionally constructed cDNA library to produce a set of expressed sequence tags (ESTs).


Input: Characterization of an EcR/USP heterodimer target site that mediates ecdysone responsiveness of the Drosophila Lsp-2 gene.

EcR

USP

Drosophila Lsp-2 gene


Input: Thus, SPECT was not as sensitive as PET in this activation task.


Input: Transcriptional activation of the chicken lysozyme gene by NF-kappa Bp65 (RelA) and c-Rel, but not by NF-kappa Bp50.

chicken lysozyme gene

NF-kappa Bp65

RelA

c-Rel

NF-kappa Bp50


Input: The results indicate that the bradycardic agents alinidine and zatebradine do not exert antiarrhythmic efficacy against SVT induced during subacute myocardial infarction in conscious dogs.


Input: In vivo, selective activation of SAPKs stimulates formation of the ternary complex containing Elk-1, serum response factor and the serum response element, and enhances Elk-1-dependent transcription.

SAPKs

serum response factor


Input: An epidemic of hepatitis B virus infection among intravenous drug users in Iceland.


Input: Three of these subunits are also homologous to the dimeric POR from a mesophilic archaeon, Halobacterium halobium (21% identity).

POR


Input: The transposon-inactivated gene, designated pilP, is 525 bp long, potentially encoding a 19. 1-kDa protein precursor that contains a typical membrane lipoprotein leader sequence.

pilP


Input: Cheung and S.


Input: Upstream of the dra gene an open reading frame of 313 amino acids was identified.

dra gene


Input: Sucrose-specific regulation of scrB was also lost upon deletion of 4 bp of a palindromic sequence (OB) covering positions + 6 to + 21 downstream of the scrB transcriptional start site.

scrB

scrB


Input: In E. coli, CheW mediates the physical coupling of the receptors to the kinase CheA.

CheW

CheA


Input: The promoter of the first gene, epiF, responded to the activator protein EpiQ and contained a palindromic sequence similar to the EpiQ binding site of the epiA promoter, which is also activated by EpiQ.

epiF

activator protein EpiQ

EpiQ binding site

epiA promoter

EpiQ


Input: CXC chemokines bind to unique sets of selectivity determinants that can function independently and are broadly distributed on multiple domains of human interleukin-8 receptor B.

interleukin-8 receptor B


Input: Oligodeoxynucleotides antisense to the predicted translation initiation regions of ICP4 and pp38 mRNAs inhibited proliferation of MSB1 cells but not MDCC-CU91 (CU91) reticuloendotheliosis virus-transformed cells.

pp38 mRNAs


Input: Retroviral replication requires that a portion of the primary transcripts generated from proviral DNA be spliced to serve as mRNA for the envelope protein and in Rous sarcoma virus as src mRNA.

envelope protein

src mRNA


Input: In this case the degree of promoter methylation, which could extend beyond the T-DNA borders, was not correlated with the reduction in steady-state poly (A) + mRNA levels, the silenced state was transmitted through meiosis and reactivation lasted several generations.


Input: Thus, the consensus sequences for phosphatase regulation are 5'-GCACGTGGG-3' and 5'-GCACGTTTT-3' which differ from the binding sequences for the Cpflp protein required for transcription of the genes in methionine biosynthesis and for centromere function.

Cpflp


Input: Here we report that the proline-rich region of CAP is recognized by the SH3 domains of several proteins, including the yeast actin-associated protein Abp1p.

CAP

SH3 domains

yeast actin-associated protein Abp1p


Input: We have identified and characterized a vitamin D response element (VDRE) in the promoter of c-fos.

c-fos


Input: In addition to protein binding at sequences known to be involved in the regulation of transcription, genomic footprinting of the entire promoter region also showed that a protein factor is constitutively bound to the first intron of the rep3 gene.

rep3 gene


Input: Differentiation was not observed after cellular expression of GTPase-deficient forms of alpha i2 or alpha 0, indicating selectivity for the Gq family of G proteins.

GTPase

alpha i2

alpha 0

Gq family

G proteins


Input: Consistent with a possible role in transcription, Paf1p is localized to the nucleus.


Input: By comparing the abundances of many yeast transcripts in isogenic wild-type and paf1 mutant strains, we have identified genes whose expression is affected by PAF1.

paf1 mutant


Input: Paf1p may therefore be required for both positive and negative regulation of subsets of yeast genes.


Input: Using a high-copy suppression strategy, we have identified a yeast gene (UBS1) whose elevated expression suppresses the conditional cell cycle defects associated with cdc34 mutations.


Input: Molecular characterization of malignant melanoma of soft parts or soft tissue clear cell sarcoma which shares t (12; 22) chromosome translocation revealed fusion of EWS with a transcriptional factor gene ATF-1.

EWS

gene ATF-1


Input: Clones that expressed DBD exhibited a dominant negative phenotype and did not elicit antiviral activity against vesicular stomatitis virus (VSV) infection upon IFN treatment.

IFN


Input: Abp1 preferentially binds to multiple sites in ARS 3002 and to the DNA polymer poly [d (A. T)].

ARS 3002


Input: Identification, purification, and molecular cloning of autonomously replicating sequence-binding protein 1 from fission yeast Schizosaccharomyces pombe.

autonomously replicating sequence-binding protein 1 from fission yeast Schizosaccharomyces pombe


Input: A short open reading frame (ORF2), of unknown function, is present in all FIV isolates.


Input: The patient was homozygous for the underlying mutation, which was found to be a G--> T transversion within the acceptor splice site between intron e and exon 6, abolishing normal RNA splicing.


Input: These regions overlap with the HIT protein similarity regions.

HIT protein similarity regions


Input: We tested 10 rats with electrophysiologically guided, ibotenic acid lesions of the PBN (PBNx) to determine whether they could acquire a LiCl-induced CTA to l-alanine (0. 3 M) or demonstrate a sodium appetite following furosemide treatment and overnight access to sodium deficient chow.


Input: Liposomal Amphotericin-B failed in 6/7 patients with culture-proven mycosis who died from infection with Aspergillus (n = 2) and Candida (n = 4), respectively.


Input: Mg2 + and Mn2 + compete for binding sites, with the former having lower affinity.


Input: Magnetic storm indicators could be used in medicine, in geophysics and for special purposes.


Input: Transgenic tobacco plants (ppa-1) constitutively expressing Escherichia coli pyrophosphatase behind the 35S CaMV promoter accumulate high levels of soluble sugars in their leaves [27].

Escherichia coli pyrophosphatase

35S CaMV promoter


Input: Hb levels remained adequate (Hb = 10. 68 +/-0. 77 g/dl) after 14. 6 +/-7. 64 months.

Hb

Hb


Input: CBT is discussed in comparison with the Wisconsin Card Sorting Test as a potential cognitive activation task for functional neuroimaging of the frontal lobes.


Input: These data indicate that although 218leu retains normal transactivation activity on a p53 promoter in yeast at physiological temperatures, it is not capable of normal p53 function in the presence of a 248trp allele in SNU-C5 cells.

p53 promoter

248trp allele


Input: Neither class II nor IV infections precluded transplantation.


Input: Although a great deal is understood about how bHLH factors activate gene transcription via E-box DNA consensus sequences, studies of bHLH factor function in higher eukaryotes often have been hindered by the presence of multiple family members.

bHLH factors

bHLH factor


Input: Mobility and supershift assays demonstrated that upstream stimulatory factor (USF) and Sp1 bind to the former elements and competition experiments confirmed that CREB/ATF and AP-1 bind to the CRE/TRE element.

upstream stimulatory factor

USF

CREB

ATF


Input: In these cases, greatly increased human chorionic gonadotropin (hCG) levels and suppressed TSH levels suggest that hCG has thyrotropic activity.

human chorionic gonadotropin

hCG

TSH

hCG


Input: High fibrinogen levels could thus be a risk for perioperative thrombosis.

fibrinogen


Input: Strontium chloride Sr 89 is costly, but preliminary analysis indicates that it may reduce management expenditures overall. (ABSTRACT TRUNCATED AT 250 WORDS)


Input: We propose that epigenetic features of tissue-specific control and of the control of allelic expression are intricately linked.


Input: This study determined the arthritogenic potential of silicone gel by either mixing it with bovine collagen II (BII) or by injecting silicone gel alone in DA rats.

bovine collagen II

BII


Input: This 5' splice site sequence was required for enhanced polyadenylation and was recognized by both U1 small nuclear ribonucleoproteins (snRNPs) and alternative splicing factor/splicing factor 2 (ASF/SF2).

U1 small nuclear ribonucleoproteins

alternative splicing factor

splicing factor 2

ASF


Input: This analysis revealed that SAP 145, together with four other SF3a/SF3b subunits, UV cross-links to pre-mRNA in a 20-nucleotide region upstream of the BPS.

SAP 145


Input: Although the consumption of myoglobin-bound O2 (MbO2) stores in seal muscles has been demonstrated in seal muscles during laboratory simulations of diving, this may not be a feature of normal field diving in which measurements of heart rate and lactate production show marked differences from the profound diving response induced by forced immersion.

myoglobin


Input: The human purH cDNA is 1776 base pairs in length encoding for a 591-amino acid polypeptic (Mr = 64, 425).

human purH cDNA


Input: The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint.

gene MPS1


Input: In our opinion, the SM-CMA system is, despite some shortcomings in its user-interface, a useful and versatile instrument for examination of human semen samples, with desirable features.


Input: Oligonucleotides, designed on the basis of conserved flanking amino acid sequence segments within the catalytic domain of eukaryotic protein kinase C (PKC) proteins, were used as primers for polymerase chain reactions to amplify a 427-bp chromosomal DNA fragment from the filamentous fungus Trichoderma reesei.

eukaryotic protein kinase C

PKC


Input: Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis.

RB


Input: Apparent loss of differentiation markers characterizes advanced malignant neoplasms.


Input: The method has been satisfactorily applied to the determination of paracetamol in pharmaceutical formulations and biological fluids.


Input: These primers yielded a PCR product of a characteristic length within most Xanthomonas species and pathovars tested.


Input: Rad6 mutants display a remarkably pleiotropic phenotype, implicating the protein in DNA damage-induced mutagenesis, postreplication repair, repression of retrotransposition, and sporulation.

Rad6 mutants


Input: RNase protection assays revealed a correlation between the levels of dorsal and ventral skin expression with pigmentation/phaeomelanin phenotypes.

RNase


Input: Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases.

cyclin D-dependent kinases


Input: Overproduction of HrcA protein from a second copy of hrcA derived from a plasmid (phrcA +) in B. subtilis wild-type and delta hrcA strains prevented heat shock induction of the dnaK and groE operons at the level of transcription almost completely and strongly reduced the amounts of mRNA at a low temperature as well.

HrcA protein

hrcA

phrcA

hrcA

dnaK

groE operons


Input: We report the molecular cloning and functional characterization of USF2 isoforms, corresponding to a 44-kDa subunit, USF2a, and a new 38-kDa subunit, USF2b, generated by differential splicing.

USF2 isoforms


Input: The preferential heterodimerization of USF subunits was reproduced ex vivo, while the in vitro association of cotranslated subunits, or recombinant USF proteins, appeared to be random.

USF subunits

recombinant USF proteins


Input: Activated PKR may exist as a dimer and phosphorylates the eukaryotic translation initiation factor 2 alpha subunit (cIF-2 alpha) to inhibit polypeptide chain initiation.

PKR

eukaryotic translation initiation factor 2 alpha subunit

cIF-2 alpha


Input: GRP78, a molecular chaperone expressed in the endoplasmic reticulum, is a " glucose-regulated protein " induced by stress responses that deplete glucose or intracisternal calcium or otherwise disrupt glycoprotein trafficking.


Input: The IL-8 receptor is a seven-transmembrane spanning receptor coupled to specific heterotrimeric G proteins including Gi and G16.

IL-8 receptor

heterotrimeric G proteins

Gi


Input: In a second series of experiments, the efficacy of PDC/HDC Ac was evaluated in both single and multiple dose regiments.


Input: To elucidate the functional significance of Fyn in the expression of viral promoters, we transfected a Fyn-expression vector together with a reporter plasmid containing the chloramphenicol acetyltransferase gene driven by HIV LTR into a human T cell line, Jurkat.

Fyn

Fyn

chloramphenicol acetyltransferase gene

HIV LTR


Input: We conducted a prospective, randomized controlled trial of metoprolol, a selective beta-blocker for prevention of gastrointestinal bleeding from portal hypertension in 29 non-selected patients with liver disease and previous gastrointestinal bleeding.


Input: A genetic and molecular analysis of non-inducible qutA mutants showed that all 23 mutations analysed map within the N-terminal half of the encoded QUTA protein.

qutA mutants

QUTA protein


Input: These studies indicate that the acidimetric test was less sensitive than the chromogenic cephalosporin substrates and that nitrocefin and S1 could be used to screen for beta-lactamase production in these tested species.

beta-lactamase


Input: Suppressors of defective silencing in yeast: effects on transcriptional repression at the HMR locus, cell growth and telomere structure.

HMR locus


Input: Although ANP induced systemic capillary filtration, in the calf, filtration was reduced with ANP.

ANP

ANP


Input: Recent literature has suggested that beta-2 transferrin can also be used as a clinical marker for perilymph.

beta-2 transferrin


Input: With current methodology beta-2 transferrin does not appear to be a reliable clinical marker for perilymph in the operative setting.

beta-2 transferrin


Input: The hIGF-I gene has two promoters, P1 and P2.

hIGF-I gene


Input: Gel mobility shift assays indicated that at least four nuclear proteins with distinct biochemical and binding properties possess the ability to bind the 3 beta I-A element to produce four DNA-protein complexes (R1 to R4).


Input: Sixty-five patients (aged between 3 years 5 months and 60 years) suffering from medically resistant temporal lobe epilepsy (TLE) were operated on over a period of 33 months in Bethel Epilepsy Center.


Input: Significant correlations existed between FEV1 and the corresponding values of Raw, MEF50 and MEF25, although there were considerable individual differences between test results.


Input: Hybrid female mice (C57BL x CBA) were paired with breeder males (CD-1) and LNG pellets were implanted on day 0, the day on which copulation plugs were found, or on day 2 or day 3 in the postcoital period.


Input: This gene encodes a putative transcription factor with regions of homology to several other proteins including the zinc fingers and other domains of the Drosophila trithorax gene product, and the " AT-hook " DNA-binding motif of high mobility group proteins.

Drosophila trithorax gene product

high mobility group proteins


Input: Using reference probes as internal standards, we show that the ost transcription unit is located within the cytogenetic band interval 89A1, 2 on the right arm of the third chromosome, and that it exerts diagnostic segmentation gene expression patterns in the embryo.

ost transcription unit


Input: The purified recombinant enzyme catalyzed specific phosphoryl transfer from ATP to UMP and CMP.


Input: Studies on the life cycle of Haplorchis pumilio (Looss, 1896) Looss, 1899 with morphological redescription of larval and adult stages.


Input: Regressing microaneurysms in 5 cases of hepatitis B virus related polyarteritis nodosa.


Input: During the following pregnancy ultrasonographic studies of the male fetus in the 16th week of gestation revealed severe micrognathia, short and wide thumbs, and big toes, and bowed tibiae.


Input: Despite an overall survival rate of 43%, survival to discharge varied greatly (0 to 100%) among the 24 diagnostic groups: tumor lysis syndrome and systemic lupus erythematosus (3/3 patients each, 100%), hemolytic uremic syndrome (8/9 patients, 89%).


Input: One hundred units/kg of recombinant human erythropoietin (rhEPO) was given subcutaneously 3 times a week for 3 weeks.

recombinant human erythropoietin

rhEPO


Input: A 3-week regimen of erythropoietin may help prevent the donor' s need to receive allogeneic blood transfusion, when the initial Hb levels were below 130 milligrams.

erythropoietin

Hb


Input: The mean body mass index (BMI) was 31. 8 +/-6. 3 kg/m2 and 28. 5 +/-6. 3 kg/m2 in women and men, respectively.


Input: These findings demonstrate that haemodialysis patients with chronic hepatitis C respond well to interferon treatment and that a long-term response is achieved in a high proportion of patients.

interferon


Input: Synthetic enantiomers of drugs


Input: Polysome analysis further indicated that these germ cell-specific Sp1 mRNAs are translated, albeit with a lower efficiency than the somatic transcript.

germ cell-specific Sp1 mRNAs


Input: In nondiabetics the response of tcPO2 but not of LDF was influenced by the values at rest.


Input: This study proposes an estimator for such global synchronizing effects upon unit-pair correlations based on local field potentials (LFPs).


Input: The assembly of sequence ready, high-resolution physical maps and construction of minimally overlapping contigs for the human as well as model genomes requires accurate determination of the extent of overlap between adjacent clones as well as their relative orientation.


Input: The DNA sequences upstream of these termini exhibit homology to plant mitochondrial-processing sites, therefore the proximal 5' ends are most probably generated by RNA processing.


Input: Curing shrinkage and volumetric changes of resin-modified glass ionomer restorative materials.


Input: Here we present genetic evidence suggesting that PP2A functions downstream of Ras1 in the Sevenless receptor tyrosine kinase (RTK) signal transduction pathway that specifies R7 photoreceptor cell fate in the developing Drosophila eye.

Sevenless receptor tyrosine kinase

RTK


Input: QBMDs for a 5% change in response (QBMD05) were 6-fold lower, on average, than the corresponding NOAEL.


Input: The gene encodes an ATP-binding cassette, ABC transporter.

ATP-binding cassette

ABC transporter


Input: The T-box motif is present in a family of genes whose structural features and expression patterns support their involvement in developmental gene regulation.


Input: Molecular analysis of a novel schizosaccharomyces pombe gene containing two RNP consensus-sequence RNA-binding domains.


Input: Do overall treatment time, field size, and treatment energy influence local control of T1-T2 squamous cell carcinomas of the glottic larynx? PURPOSE: To evaluate treatment and patient related prognostic factors that may influence local control in the treatment of T1-T2 squamous cell carcinoma of the glottic larynx.


Input: In contrast to the signaling triggered by surface Ig engagement in B lymphocytes, CD38 ligation did not appear to induce tyrosine phosphorylation of the src-like protein tyrosine kinases lyn, fyn, and btk, or of vav-and ras-GTPase-activating protein, nor did it induce detectable changes in cytosolic CA2 + concentrations.

Ig

src-like protein tyrosine kinases lyn

fyn

btk

vav-and ras-GTPase-activating protein


Input: Mutations in the alpha-amanitin conserved domain of the largest subunit of yeast RNA polymerase III affect pausing, RNA cleavage and transcriptional transitions.

alpha-amanitin

yeast RNA polymerase III


Input: The evidence presented here suggests that the p40 complex is a ribonucleoprotein complex containing L1Hs RNA (s) and that protein-protein interactions in which alpha-helix structures participate, for example coiled-coils, may occur in the complex.

p40 complex

L1Hs RNA (s)


Input: Our data suggest that trans-activation from the prothymosin intron enhancer is a faithful reflection of the transforming properties of the Myc protein.

prothymosin intron enhancer

Myc protein


Input: The 5' external transcribed spacer (ETS) region of the pre-rRNA in Saccharomyces cerevisiae contains a sequence with 10 bp of perfect complementarity to the U3 snoRNA.

U3 snoRNA


Input: These animals were viable and fertile.


Input: These data suggest that RPF-1 is likely to be involved in early steps in the differentiation of amacrine and ganglion cells.


Input: Carboxy-terminal Spc110p truncations lacking the calmodulin binding site can support growth and are also phosphorylated in a cell cycle-specific manner.

calmodulin


Input: Both EWS-FLI-1 and FLI-1 proteins function as transcription factors that bind specifically to ets sequences (the ets boxes) present in promoter elements.

EWS

FLI-1 proteins

ets

ets


Input: In electromobility shift assays, EWS-FLI-1 binding to the SRE is detectable in the absence of SRF whereas the binding of FLI-1 is not, suggesting that the interaction with DNA is the step which limits ternary complex formation by FLI-1.

EWS

SRF


Input: Additional studies with new and reprocessed regenerated cellulose dialyzers comparing 450 and 220 mL/min blood flow rates at 10 minutes showed no change in BTG.


Input: DNA methylation, especially of either one or both of the deoxyadenosines at the two GATC motifs (one in the first exon and the other in the first intron of the rice CatA gene), appeared to be responsible for the CatA promoter activity identified in the transient assay.

CatA gene

CatA promoter


Input: The viral LTR was used as the promoter.

viral LTR


Input: Overlapping cDNA clones were isolated and sequenced.


Input: Epitope mapping revealed that these three clones appear to recognize an identical epitope domain present on the C-terminal RNP motif of the U1A protein.

U1A protein


Input: Variables evaluated were number of weekly anginal events, data from ergometric exercise testing with simultaneous electrocardiographic registration, semiquantitative evaluation of Tc-99m 2-methoxy isobutyl isonitrile (MIBI) scans and rheologic variables.


Input: As the length of the fatty acid decreased, the binding affinity was reduced; myristic acid (14: 0) bound with a K (d) of 1409 +/-423 nM, but medium-chain (decanoic acid, 10: 0) and short-chain (octanoic acid, 8: 0) lipids were not bound at all.


Input: The membrane-distal cytoplasmic region of human granulocyte colony-stimulating factor receptor is required for STAT3 but not STAT1 homodimer formation.

human granulocyte colony-stimulating factor receptor

STAT1 homodimer


Input: However, whether or not nonsense codon recognition within TPI transcripts takes place prior to or after splicing remained unresolved.

TPI transcripts


Input: Although some residues are found reactive toward dimethylsulphate and kethoxal in regions predicted to be unpaired by the phylogenetic secondary structure model of 4. 5S RNA, generally the reactivity is low, and some residues in internal loops are not reactive at all.

4. 5S RNA


Input: Ongoing and future investigations may better define the optimal approach for local control, the optimal duration of maintenance chemotherapy, and the possible role of biologic response modifiers and growth factors in further improving the outcome for patients with this disease.


Input: SUMMARY OF REVIEW: We discuss the criteria that make such studies comparable, drawing on the experiences of recent studies performed around the world.


Input: Forty-five patients with pleural lesions identified on CT scans were subsequently examined by MR imaging at 0. 5 T.


Input: RESULTS: Basal plasma IGF-I levels as well as body mass index (BMI) were lower in amenorrheic patients than in healthy controls.

plasma IGF-I


Input: The alpha T3-1 cell line, a GnRH-responsive gonadotroph cell line developed by targeted oncogenesis in transgenic mice, was used to study regulation of the glycoprotein hormone alpha-subunit by activin.

GnRH

glycoprotein hormone alpha-subunit

activin


Input: Cotransfection with the ie1 gene resulted in a dramatic increase in the amount of the two enzymes expressed in the transfected cells.

ie1 gene


Input: As expected, glycosylation of Env produced from mutants was affected but, irrespective of the glycosylation phenotype, (i) similar quantities of Env were synthesized, (ii) the immunoreactivity of V3 was similar, (iii) gp160 was efficiently cleaved into gp120 and gp41, (vi) Env was exposed at the cell membrane, (v) secreted gp120 bound CD4, and (vi) membrane gp41 was able to induce membrane fusion with CD4 + cells.

Env

Env

Env

CD4 +


Input: Effects of posteroventral pallidotomy on Parkinson' s disease.


Input: On the trail of Dr.


Input: However, only complete DnaJ can cooperate with DnaK and a third protein, GrpE, in refolding denatured firefly luciferase.

complete DnaJ

DnaK

GrpE

denatured firefly luciferase


Input: The two different phosphoforms of STAT5 have identical in vitro DNA binding specificity and reactivity with tyrosine phosphopeptides, but differ in their cellular localization.


Input: We have isolated a novel protein from Drosophila nuclear extracts which binds specifically to a site in this second region.


Input: Control of transcription of the erbB-2 gene is an important determinant of receptor expression.

erbB-2 gene


Input: DNase I footprinting and electrophoretic mobility shift assays indicate that PBP binds to the half-site of each palindrome with the core recognition sequence TGGGAG.

DNase I

PBP


Input: These results demonstrate that sequences in the SH2/SH3/SH2 region of p120 GAP are required for full catalytic activity toward Ras.

p120 GAP

Ras


Input: Further analysis of this domain by in vitro mutagenesis pointed to a core of hydrophobic and acidic residues as critical for the activity.


Input: Analysis of RAR alpha mutants in transfection studies reveals that the DNA binding domain is sufficient for inhibition of BZLF1 activity.

RAR alpha mutants


Input: We measured serum hepatocyte growth factor (HGF) in patients with acute myocardial infarction, angina pectoris, and other heart diseases.

serum hepatocyte growth factor

HGF


Input: The neural mechanism of parkinsonian motor symptoms, i. e., rigidity, tremor and akinesia, which are the result of nigrostriatal dopamine deficiency, is interpreted from long-term observations on the effect of surgical and pharmacological treatment of the disease in relation to the neuropathological findings within the substantia nigra zona compacta (SNc).


Input: Protein splicing: evidence for an N-O acyl rearrangement as the initial step in the splicing process.


Input: In agreement with these data, western blot experiments using an antibody directed against the carboxy-terminal portion of the mouse c-kit protein showed that a polypeptide, of the size predicted by the open reading frame of the spermatid-specific c-kit cDNA, accumulates in the latest stages of spermatogenesis and in epididymal spermatozoa.

c-kit protein

spermatid-specific c-kit cDNA


Input: It is shown that the (G + C)-rich element of the aldolase C promoter directs transcription in neuronal as well as in nonneuronal cells.

aldolase C promoter


Input: Treatment of keratinocytes expressing a normal epidermal growth factor receptor (EGFR) with TGFalpha or epidermal growth factor for 5 min induced PKCdelta tyrosine phosphorylation.

epidermal growth factor receptor

EGFR

TGFalpha

epidermal growth factor

PKCdelta


Input: Only one of these bands was supershifted by antibody to p50, whereas antibodies to p65 or other NF-kappaB proteins had no effect.

NF-kappaB proteins


Input: We isolated a complementary DNA (cDNA) clone from an RL95-2 expression library that encodes the C1 site-binding protein.

C1 site-binding protein


Input: Biol.


Input: In addition, anti-phosphotyrosine antibodies immunoprecipitated 80K-H from cell lysates of FGF-stimulated but not from control fibroblasts.

anti-phosphotyrosine antibodies

FGF


Input: The novel protein kinases, c-Jun NH2-terminal kinases (JNKs)/stress-activated protein kinases, are also activated by TNF-alpha, IL-1, and CD28 costimulation.

c-Jun NH2-terminal kinases

JNKs

stress-activated protein kinases

TNF-alpha


Input: Thus, hGRbeta potentially functions as a dominant negative inhibitor of hGRalpha activity.

hGRbeta

hGRalpha


Input: Gas6 contains an NH2-terminal Gla domain followed by four epidermal growth factor-like repeats and tandem globular (G) domains.

epidermal growth factor-like repeats


Input: Both P5CDh cDNA clones detect a single 3. 2-kb transcript on Northern blots of multiple human tissues, indicating the long cDNA containing the 3'-untranslated intron represents the predominant transcript.

P5CDh cDNA


Input: Polymerization of neurofilament L protein in vitro was inhibited by phosphorylation of neurofilament L protein by PKN.

neurofilament L protein

neurofilament L protein

PKN


Input: We and others have demonstrated that the c-cbl proto-oncogene product is one of the earliest targets of tyrosine phosphorylation upon T cell receptor stimulation.

c-cbl proto-oncogene product

T cell receptor


Input: A substantial fraction of Cbl was constitutively associated with Grb2 and this interaction was mediated by Grb2 SH3 domains.

Cbl

Grb2 SH3


Input: An AP-1 binding sequence is essential for regulation of the human alpha2 (I) collagen (COL1A2) promoter activity by transforming growth factor-beta.

AP-1 binding sequence

human alpha2 (I) collagen

transforming growth factor-beta


Input: Only two patients (0. 3%) had a CA 125 response at the time of clinical progression.

CA 125


Input: The men self-selected a prescribed diet at home emphasizing saturated fat as the visible fat for 1 week.


Input: These results illuminate a hitherto unanticipated function of U6 RNA: the modulation of a phosphorylation-dephosphorylation cycle of C1 hnRNP protein that influences the binding affinity of this protein for pre-mRNA.

U6 RNA

C1 hnRNP protein


Input: Inclusion of the extended N terminus into the originally reported protein resulted in a striking similarity to the lymphoid factor Lef-1.

lymphoid factor Lef-1


Input: Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2.

mammalian Notch1

RBPJk

Epstein-Barr virus EBNA2


Input: Electrophoretic mobility shift assays (EMSAs) using purified glucocorticoid receptor DNA binding domain (DBD) demonstrated that both GRE-2 and-3 motifs interact with DBD and oligonucleotide competition experiments established that these have different affinities for DBD.

glucocorticoid receptor DNA binding domain

GRE-2 and-3 motifs


Input: The large subfamily of receptor tyrosine kinases (RTKs) for which EPH is the prototype have likely roles in intercellular communication during normal mammalian development, but the biochemical signalling pathways utilised by this family are poorly characterised.

receptor tyrosine kinases

RTKs

EPH


Input: The 17-kDa protein is required for the systemic infection of plants.


Input: We present here a detailed genomic sequencing analysis of the cytosine methylation patterns of the transposase binding sites within both Ac ends in the wx-m9:: Ac allele, where Ac is inserted into the tenth exon of the Waxy gene.

transposase

Ac

Ac allele

Ac

Waxy gene


Input: Krox-20, a zinc finger gene, has a highly conserved pattern of expression in r3 and r5 and is functionally required for their maintenance in mouse embryos.

zinc finger gene


Input: Pituitary adenylate cyclase-activating polypeptide regulates prolactin promoter activity via a protein kinase A-mediated pathway that is independent of the transcriptional pathway employed by thyrotropin-releasing hormone.

adenylate cyclase-activating polypeptide

prolactin promoter

protein kinase A

thyrotropin-releasing hormone


Input: Clones 33F and 34B encoded identical aromatase proteins of 503 amino acids, but differed in size due to alternative polyadenylation signal usage for the corresponding mRNAs.

aromatase proteins


Input: In sorted bone marrow cells expression of both VpreB genes was detected in pro-B/pre-BI and large pre-BII cells, while the RNA steady state levels were at least 100-fold lower in small pre-BII and immature/mature B cells.

VpreB genes


Input: We have cloned and sequenced a 3574-bp Bacillus subtilis (Bs) DNA fragment located between the nrdA and citB genes at about 169 degrees on the chromosome.

nrdA

citB genes


Input: Aeromonas salmonicida possesses two genes encoding homologs of the major outer membrane protein, OmpA.

major outer membrane protein

OmpA


Input: Expression of Msp was toxic to E. coli when the entire msp gene was present.

Msp

msp gene


Input: In agreement with previous in vitro data, we have shown that UmuD and UmuD' are able to form both homodimers (UmuD-UmuD and UmuD'-UmuD') and a heterodimer (UmuD-UmuD').

UmuD

UmuD'

UmuD

UmuD

UmuD'

UmuD'

UmuD

UmuD'


Input: Lyn kinase immunoprecipitated from lysates of irradiated BCP as well as a full-length glutathione S-transferase (GST)-Lyn fusion protein-phosphorylated recombinant human p34cdc2 on tyrosine 15.

Lyn kinase

glutathione S-transferase

GST

Lyn

recombinant human p34cdc2


Input: Binding specificity and modulation of the ApoA-I promoter activity by homo-and heterodimers of nuclear receptors.

ApoA-I promoter


Input: There is growing evidence that mammalian AMP-activated protein kinase (AMPK) plays a role in protecting cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways.

mammalian AMP-activated protein kinase

AMPK


Input: Sterol-mediated suppression of cleavage of SREBP-1 was found to be dependent on the extreme COOH-terminal region (residue 1034 to the COOH terminus), which exists in two forms as a result of alternative splicing.


Input: Am.


Input: EMSA competition experiments showed that mutations within the direct repeats failed to compete for binding of the nuclear proteins to labeled wild type oligonucleotide.


Input: Transcription from the promoter containing the mutated direct repeats was increased greatly, consistent with the conclusion that these motifs functions in vivo to repress GPT gene expression.

GPT gene


Input: However, a > 10-fold increase in ERK3 activity in each PKC beta transfectant was shown by immunoprecipitation with anti-ERK3 monoclonal antibody followed by either immune complex kinase assay or by in gel kinase assay.

PKC beta

anti-ERK3 monoclonal antibody


Input: Sequence analysis of this 100-bp Col2a1 enhancer revealed several sequence motifs similar to motifs present within the regulatory region of the link protein gene, another cartilage gene.

Col2a1 enhancer

link protein gene


Input: Retinoid-dependent activation of the tissue transglutaminase promoter depends on both a proximal regulatory region containing sequences highly conserved between the human and the mouse tissue transglutaminase promoters and a distal region that includes a 30-base pair retinoid response element (mTGRRE1). mTGRRE1 contains three hexanucleotide half-sites (two canonical and one non-canonical) in a DR7/DR5 motif that bind both RAR * RXR heterodimers and RXR homodimers.

tissue transglutaminase promoter

mouse tissue transglutaminase promoters

RAR

RXR

RXR homodimers


Input: Significantly, pPKR is capable of specifically phosphorylating Ser51 in a synthetic eIF-2alpha peptide, a key characteristic of the eIF-2alpha kinase family.

pPKR

synthetic eIF-2alpha peptide

eIF-2alpha kinase family


Input: Vertebrate synapsins constitute a family of synaptic proteins that participate in the regulation of neurotransmitter release.

Vertebrate synapsins


Input: Electrophoretic mobility shift assays using crude extracts from FREJ4 cells revealed the binding of a member (s) of the Ets family of transcription factors to the P4 EBS, as well as the interaction of two members of the Sp1 family, Sp1 and Sp3, with the adjacent GC box.

Ets family of transcription factors

P4 EBS

Sp1 family


Input: ZEBRA and cellular AP-1 bZip activators, such as c-Fos, have homologous DNA-binding domains, and their DNA-binding specificities overlap.

ZEBRA

AP-1 bZip activators

c-Fos


Input: This result suggested that mutant I299 has diminished cap-binding activity.


Input: UV cross-linking experiments demonstrated that HSV infection caused enhanced binding of protein factors, including the 64-kDa component of cleavage stimulation factor (CstF), to poly (A) site RNAs from virus genes of all temporal classes and that this enhanced binding required expression of IE63.

64-kDa component of cleavage stimulation factor

CstF


Input: CM-ACO3 is expressed in flowers and is not induced by any of the stimuli tested.


Input: We show here that these Jun/eb1 chimeras are potent transactivators of AP1 sites and that they can cooperate with c-Ha-Ras to induce foci.

Jun

AP1 sites

c-Ha-Ras


Input: In synchronized HeLa cells, expression of luciferase activity was induced at the beginning of DNA synthesis and was dependent on the presence of an E2F-binding site in the H2A. 1 promoter.

luciferase

E2F-binding site

H2A. 1 promoter


Input: Utilizing transient transfection studies in HepG2 cells, we have shown that deletion of the factor VIII promoter sequences distal to nucleotide-44 results in a significant but small increase in promoter activity.

factor VIII promoter sequences


Input: We constructed a yeast reporter strain containing the lacZ gene under the control of the CYC1 promoter associated with three copies of TRE-1.

lacZ gene

CYC1 promoter


Input: If hnRNP K is a transcription factor, then interactions with the RNA polymerase II transcription apparatus are predicted.

hnRNP K

RNA polymerase II


Input: A developmentally regulated 4. 6 kb mRNA is recognized on Northern blots of oocyte RNA using the X. laevis cDNA.


Input: Sequence conservation is greatest for residues located near the active centers of the exo and pol domains of the E. coli DNA polymerase I structure.

exo

pol domains

E. coli DNA polymerase I


Input: Despite the favourable natural history of acute BI, mild, moderate, and severe posttraumatic changes were shown to appear as cicatricial-adhesive and atrophic processes, intracerebral cysts, porencephaly, which result in posttraumatic epilepsy, hydrocephalus, etc.


Input: Several cytokines exhibit a high degree of temporal regulation as well as somnogenic potency (e. g., interleukin-1 [IL-1], tumor necrosis factor-alpha [TNF-alpha]).

tumor necrosis factor-alpha

TNF-alpha


Input: As pH and Hb can also affect mixed venous CO2 content, the effect on Q was also assessed.

Hb


Input: No difference in elastin peptide concentration was observed between emphysematous patients and control subjects (mean +/-SD = 2. 39 +/-1. 18 micrograms/ml in patients versus 2. 55 +/-1. 34 micrograms/ml in policemen and 2. 59 +/-1. 20 micrograms/ml in coal miners).

elastin peptide


Input: Identification of this region as the E. coli tmk gene was confirmed by functional complementation of a yeast dTMP kinase temperature-sensitive mutant and by in vitro enzyme assay of the thymidylate kinase activity in cell extracts of E. coli by use of tmk-overproducing plasmids.

E. coli tmk gene

yeast dTMP kinase

thymidylate kinase

tmk


Input: The structural gene for copper-and topa quinone-containing monoamine oxidase (maoA) and an unknown amine oxidase gene have been located at 30. 9 min on the Escherichia coli chromosome.

copper-and topa quinone-containing monoamine oxidase

maoA

amine oxidase gene


Input: This interaction is mediated by the SH2 domain of Crk and can be inhibited with a phosphopeptide containing the Crk-SH2 binding motif.

SH2 domain

Crk

Crk


Input: The cDNA corresponding to the FPS1 gene was isolated by functional complementation of a mutant yeast strain defective in FPS activity (Delourme, D., Lacroute, F., and Karst, F.

FPS1 gene

FPS


Input: The isolated plasmin fragments of VEGF were compared with respect to heparin binding, interaction with soluble VEGF receptors, and ability to promote endothelial cell mitogenesis.

plasmin

VEGF

VEGF receptors


Input: The members of the Myb family of transcription factors are defined by homology in the DNA-binding domain; all bind the Myb-binding site (MBS) sequence (YG (A/G) C (A/C/G) GTT (G/A)).

Myb family of transcription factors

Myb-binding site

MBS


Input: In contrast, when the isoform containing the C epsilon4 domain joined directly to the M2 exon (IgE grande) is expressed in the J558L cell line, it is degraded intracellularly, suggesting a cell line-dependent regulation of secretion.

IgE grande


Input: Human cytomegalovirus immediate-early protein IE2 tethers a transcriptional repression domain to p53.

Human cytomegalovirus immediate-early protein IE2


Input: The specificity of action of C/EBP family members may be derived from the characteristics of each factor, including the expression profiles, the DNA binding affinities, the cofactors, and so on, in addition to the DNA binding specificities.

C/EBP family members


Input: The antibodies inhibited specifically the transcription of DNA polymerase alpha promoter in vitro.

DNA polymerase alpha


Input: Immunocytochemical analysis demonstrated the presence of DREF polypeptide in nuclei after the eighth nuclear division cycle, suggesting that nuclear accumulation of DREF is important for the coordinate zygotic expression of DNA replication-related genes carrying DRE sequences.

DREF polypeptide

DREF


Input: A DNA fragment carrying 1, 100 nucleotides derived from the 5'-flanking region of the UGT1A1 gene was enough for MC induction.

UGT1A1 gene


Input: This result supports the argument that the beta' subunit plays an essential role in determining the progress of transcription elongation.


Input: Two XPG regions with putative NLS [amino acid (AA) coordinates: NLS-B (AA 1057-1074) and NLS-C (AA 1171-1185)] were each shown to independently localize the beta-gal extensively (> 80%) to the nucleus of HeLa cells.

XPG regions

beta-gal


Input: The lacS gene was cloned in an E. coli-Streptococcus shuttle vector and was expressed both in a lacS deletion derivative of S. thermophilus and in a pNZ63-cured strain, L. lactis NZ6091.

lacS gene

lacS


Input: The genome of all retroviruses consists of two identical RNAs noncovalently linked near their 5' end.


Input: The extraction recovery of Amphotericin B from the cerebrospinal fluid is higher than 90% over the entire linear range.


Input: HuEpo-R Ab inhibited Epo-induced parental UT-7 cell growth, but not that of cells of clone 12, suggesting that the muEpo-R is able to induce human UT-7 cell proliferation.

HuEpo-R Ab

Epo

muEpo-R


Input: The frequency of integrations that led to transcription of the lacZ gene was estimated to be 0. 5% of all integrations, of which 14% were downregulated on differentiation of 32D cells towards neutrophils.

lacZ gene


Input: Interaction of the Fur repressor with a 150-bp fragment encompassing the pvdS promoter was demonstrated in vivo by the Fur titration assay and confirmed in vitro by gel retardation experiments with a partially purified Fur preparation.

Fur repressor

pvdS promoter

Fur

Fur


Input: This protein encoded by this cDNA, which we have termed p150TSP (for TPR-containing, SH2-binding phosphoprotein), is located predominantly in the nucleus and is highly conserved in evolution.

SH2-binding phosphoprotein


Input: Both mutant receptors were expressed on the cell surface and bound insulin normally, but showed markedly impaired autophosphorylation in response to insulin.

insulin

insulin


Input: EMBO J.


Input: Taken together, our results indicate that thrombin-stimulated vascular smooth muscle proliferation is delayed and requires the de novo expression of one or more autocrine mitogens.

thrombin


Input: Transcription from adenovirus E2-early promoter is controlled by a unique array of four cis-acting elements which include an atypical TBP site, two E2F sites present in an inverted orientation relative to each other, and an ATF site.

adenovirus E2-early promoter

TBP site

E2F sites

ATF site


Input: Furthermore, we showed that the IL-6/interferon gamma (IFN gamma) response element in the IRF-1 promoter (IR/IRF-1), which contains a Stat-binding site and an adjacent CRE-like site, also makes IL-6-induced binding complexes similar to JRE-IL6-BCs.

interferon gamma

IFN gamma

IRF-1 promoter

IR

Stat-binding site


Input: A second peptide (amino acids 58-77) also antagonized p21-activity, but this peptide did not affect the ability of p21 to interact with cyclin E/Cdk2.

cyclin E


Input: A p21 peptide spanning amino acids 139-164 was found to bind PCNA in a filter binding assay and this peptide suppressed recombinant p21-PCNA interaction.

p21 peptide

PCNA

PCNA


Input: Results were supported by the agar diffusion method for Y. enterocolitica, whereas inhibition activity was not found for A. hydrophila.


Input: OND 8 mg tid days 2-3, and 8 mg tid prn days 4-5 and prednisolone 75-100 mg qds days 2-5 and 2) MCP 30 mg/metylprednisolone 80 mg i. v. before CT and MCP 20 mg p. r. after 4 and 8 h respectively.


Input: The dynamic properties of this protein fragment were measured and analyzed using both isotropic and anisotropic models of molecular motion.


Input: Adduction of the human N-ras codon 61 sequence with (-)-(7S, 8R, 9R, 10S)-7, 8-dihydroxy-9, 10-epoxy-7, 8, 9, 10-tetrahydrobenzo [a] pyrene: structural refinement of the intercalated SRSR (61, 2) (-)-(7S, 8R, 9S, 10R)-N6-[10-(7, 8, 9, 10-tetrahydrobenzo [a] pyrenyl)]-2'-deoxyadenosyl adduct from 1H NMR.

human N-ras codon 61 sequence


Input: This fragment can bind several trans-acting factors in vitro, including GATA-1 and members of the Ets family.

Ets family


Input: These different observations exclude a heterozygosity of the A--> G mutation at codon beta 77, as well as a deletion comparable to that of Hbs Lepore or Kenya, or a beta-globin gene duplication, and point to a nontraditional inheritance of Hb Costa Rica.

Hbs Lepore or Kenya

beta-globin gene

Hb Costa Rica


Input: This is the first description, to our knowledge, of regulatory elements that control expression of a gene encoding a B7 costimulatory molecule.

B7 costimulatory molecule


Input: DNA-STAT complexes were detected in all Bcr/Abl-transformed cell lines and they were supershifted by antibodies against STAT1 and STAT5.

DNA-STAT complexes

Bcr

Abl


Input: When overexpressed in an appropriate cell line, TAN-1C prevented kappa B-dependent transactivation in transient reporter gene assays in a fashion similar to the structurally related protein, Bcl-3.

kappa B


Input: T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells.

Notch

Notch

I kappa B

nuclear factor-kappa B


Input: Polyprotein processing in Southampton virus: identification of 3C-like protease cleavage sites by in vitro mutagenesis.

3C-like protease


Input: The humanized LL2 (hLL2), lacking light chain variable region glycosylation, exhibited immunoreactivities that were comparable to that of chimeric LL2 (cLL2), which was shown previously to have antigen-binding properties similar to its murine counterpart, suggesting that the VK-appended oligosaccharides found in mLL2 are not necessary for antigen binding.

humanized LL2

light chain variable region

chimeric LL2


Input: An apparent N-terminal transit peptide in the coding region and a 3' poly (A) tail exist in the cDNA clone indicated that this chloroplast protein as nuclear encoded.


Input: Thus, a critical question is how HOX proteins select the correct sets of target genes in vivo.

HOX proteins


Input: RAS2val19, a dominant activated form of Saccharomyces cerevisiae Ras2, stimulates both filamentous growth and expression of a transcriptional reporter FG (TyA):: lacZ but does not induce the mating pathway reporter FUS1:: lacZ.

Saccharomyces cerevisiae Ras2

FG

TyA

lacZ

mating pathway reporter FUS1

lacZ


Input: Moreover, the Rho family protein Cdc42, a conserved morphogenetic G protein, is also a potent regulator of filamentous growth and FG (TyA):: lacZ expression in S. cerevisiae.

Rho family protein Cdc42

morphogenetic G protein

FG

TyA

lacZ


Input: Each immunoprecipitate contained a complex of N1 (deltaEC) and CBF1.

N1 (deltaEC)


Input: This region includes verA, a structural gene previously shown to be required for ST biosynthesis, and 24 additional closely spaced transcripts ranging in size from 0. 6 to 7. 2 kb that are coordinately induced only under ST-producing conditions.

verA


Input: Subcellular localizations of the wild-type CBFbeta and the CBFbeta-SMMHC fusion protein were determined by immunofluorescence of NIH 3T3 cells that overexpress wild-type or fusion protein.

wild-type CBFbeta

CBFbeta

SMMHC


Input: Menstrual-cycle phase did not significantly affect personality variables in either group.


Input: We report the isolation of human cDNAs homologous to the Drosophila dishevelled (dsh) segment-polarity gene.

Drosophila dishevelled

dsh


Input: Ca2 + decreased Zn2 + binding in S100 beta but it did not influence binding to MRP14, suggesting that the Zn2 + binding site was distinct from and independent of the two Ca2 + binding domains.

S100 beta


Input: Two overlapping clones contained the complete Adh-2 gene composed of nine exons in a 12-kb region, with the placement of introns matching that observed in other mammalian ADH genes.

Adh-2 gene

mammalian ADH genes


Input: Ligation of CD40 rescues Ramos-Burkitt lymphoma B cells from calcium ionophore-and antigen receptor-triggered apoptosis by inhibiting activation of the cysteine protease CPP32/Yama and cleavage of its substrate PARP.

cysteine protease CPP32

Yama

PARP


Input: Large T antigen was coimmunoprecipitated by antibodies to epitope-tagged TBP, endogenous TBP, hTAF (II) 100, hTAF (II) 130, and hTAF (II) 250, under conditions where holo-TFIID would be precipitated.

Large T antigen

TBP

TBP

hTAF (II) 100

hTAF (II) 130

hTAF (II) 250

holo-TFIID


Input: Northern blot hybridization demonstrated that HEP-COP was expressed in a wide range of human adult and fetal tissues.

HEP

COP


Input: A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene.

sterol regulatory element binding protein

3-hydroxy-3-methylglutaryl coenzyme A reductase gene


Input: E3/19K resides in the endoplasmic reticulum where it binds to MHC class I molecules, thereby preventing their transport to the cell surface.

MHC class I molecules


Input: When the PHT and CSA groups were compared, Hyp levels were significantly higher in the PHT-GO + group than in the CSA-GO + group.


Input: Among the LE6 deletions, only one had a reduced transformation efficiency, while seven transformed cells at least as efficiently as wild-type LE6.

wild-type LE6


Input: ORF E8 colinear with ORF E6, which could generate a 50-amino-acid protein with a hydrophobic segment, did not transform cells when cloned into the pZipNeo vector.

ORF E8

ORF E6


Input: Clb2/Cdc28 kinase is not required for the repression of MCB-binding factor transcriptional activity in G2 and M phase.

MCB-binding factor


Input: The carboxy terminus of Mbp1 is sufficient for interaction with Swi6, and the carboxy terminus of Swi6 is required for interaction with Mbp1.


Input: Multiple single-stranded cis elements are associated with activated chromatin of the human c-myc gene in vivo.

human c-myc gene


Input: A new UASH consensus sequence derived from this mutational analysis closely matches a consensus Abf1 binding site.

Abf1 binding site


Input: We have isolated and analyzed human CTCF cDNA clones and show here that the ubiquitously expressed 11-zinc-finger factor CTCF is an exceptionally highly conserved protein displaying 93% identity between avian and human amino acid sequences.

human CTCF cDNA

11-zinc-finger factor CTCF


Input: Mutational analysis of the P2-proximal CTCF binding site and transient-cotransfection experiments demonstrate that CTCF is a transcriptional repressor of the human c-myc gene.

P2-proximal CTCF binding site

CTCF

human c-myc gene


Input: A chromosome transmission fidelity (ctf) mutant, s138, of Saccharomyces cerevisiae was identified by its centromere (CEN) transcriptional readthrough phenotype, suggesting perturbed kinetochore integrity in vivo.

chromosome transmission fidelity

ctf


Input: The growth defect of a reg1 reg2 double mutant is alleviated by a loss-of-function mutation in the SNF1-encoded protein kinase.

reg1 reg2 double mutant

SNF1-encoded protein kinase


Input: Expression of the phenylalanine hydroxylase gene in livers and kidneys of rodents is activated at birth and is induced by glucocorticoids and cyclic AMP in the liver.

phenylalanine hydroxylase gene


Input: We report here the identification of a cDNA that encodes a new member of the GTPase-activating protein (GAP) family of GTPase regulators.

GTPase-activating protein

GAP

GTPase


Input: In this study, we further investigated the regulation of the synthesis of the c-mos oncogene product, which is necessary for the activation of Cdc2.

c-mos oncogene product


Input: The heterogeneity of bovine IgG2--VIII.

bovine IgG2--VIII


Input: The ability of BCL-6 to function as a transcriptional repressor may contribute to its ability to transform B lymphocytes in diffuse large cell lymphoma.


Input: Positioning this uORF, together with its accompanying Kozak sequences, between a heterologous promoter from SV40 and a CAT reporter gene resulted in marked inhibition of CAT protein production without a decrease in CAT mRNA.

CAT reporter gene

CAT protein

CAT mRNA


Input: A secondary spread of an imported methicillin-resistant Staphylococcus aureus strain (MRSA) to two other patients occurred within a Danish surgical ward in spite of isolation of a multitraumatized index-patient immediately after arrival from a hospital in the Mediterranean area.


Input: Mesial temporal sclerosis was characterized by severe neuronal loss accompanied by gliosis occurring in the CA1/prosubiculum (27 patients, 100%), focally in the dentate gyrus (12 patients, 44%), and in the CA4 region (11 patients, 41%).


Input: Mesial temporal sclerosis.


Input: More specific adverse events, also frequently considered as dose-limiting toxicities, include hypotension with IL-1, severe headache or skin rash with IL-3, and nasal congestion and gastroduodenal lesions with IL-4.


Input: Therefore, magnetic resonance imaging was used to determine liver volume in pediatric and adolescent patients, in whom systemic clearance of three model substrates [lorazepam (0. 03 mg/kg), antipyrine (10 mg/kg), and indocyanine green (ICG; 0. 5 mg/kg)] was also determined.


Input: A mutational analysis has resolved a region of seven amino acids (amino acids 26-32) in the N-terminus of Bob1 that are important for contacting the DNA binding POU domain of Oct-1 or Oct-2.

DNA binding POU domain


Input: 155 aa, shares 78% identity with the analogous region of Xenopus laevis FGF3 and 72% identity with the product of the more distantly related human gene.


Input: The transcription start point of the proximal promoter aligns to that of mouse promoter P3 and lies within a conserved region of sequence.


Input: A novel gene designated cmr, which mapped to 18. 8 min of the Escherichia coli K-12 genome, was shown to mediate resistance to chloramphenicol when it was expressed from a multicopy vector.

cmr


Input: In addition, 5' deletions removing all but 34 bp upstream of the transcription start point retained greater than 90% promoter activity, suggesting that the-35 hexamer was not essential for promoter activity.


Input: The DNA sequence immediately upstream from the-10 hexamer contained the TGn motif described as an extended-10 region in prokaryotic promoters.


Input: An apparent ufo mRNA overexpression was not found in any of the positive leukemia cell lines, but was identified in the drug-resistant subclones of the cervix carcinoma cell line HeLa.

ufo mRNA


Input: We conclude from these studies that CKII may act as a positive regulator of myogenesis by preventing E protein homodimers from binding to muscle gene regulatory elements.

CKII

E protein homodimers


Input: The role of negative regulators such as NCE3, as well as the previously described SIN5 gene, in determining the promoter specificity of homologous activators is discussed.

SIN5 gene


Input: Transcriptional regulators utilizing the POU domain DNA-binding motif have been shown to form multi-protein complexes dependent on the POU domain itself and its flexible recognition of various octamer sequence elements.

POU domain DNA-binding motif

POU domain


Input: We found strand selective repair in DNA fragments within two active genes, DHFR and an unknown gene adjacent to DHFR.

DHFR

DHFR


Input: MATERIALS AND METHODS: Coronal 3D GRE imaging was used to study the volar, middle, and dorsal portions of the SLL in 14 patients with an arthroscopically normal SLL and in five cadaveric wrists that had a normal SLL proved with dissection.


Input: In an effort to contribute to the transcript map of human chromosome 21 and the understanding of the pathophysiology of trisomy 21, we have used exon trapping to identify fragments of chromosome 21 genes.


Input: Reproducing populations of this aphid were first detected in Puerto Rico in April 1992.


Input: The model captures the essence of predator-prey dynamics to provide reasonable predictions of population patterns.


Input: At cuticular positions exhibiting the Brd bristle loss phenotype, we have found that the progeny of the multiplied SOPs develop aberrantly, in that neurons and thecogen (sheath) cells appear but not trichogen (shaft) and tormogen (socket) cells.

Brd bristle loss phenotype


Input: Transcriptional blockade was reversed by co-transfections of a wild-type SRF expression vector, but was not rescued by the expression of other myogenic factors, such as MyoD and Mef-2C.

wild-type SRF

MyoD


Input: The mMIWC1 promoter was identified and contained TATA, CAAT, GATA, and AP-2 elements; primer extension revealed mMIWC transcription initiation at 621 bp upstream from the mMIWC1 translational initiation site.

mMIWC1 promoter

AP-2 elements

mMIWC


Input: Human MN/CA9 gene, a novel member of the carbonic anhydrase family: structure and exon to protein domain relationships.

Human MN/CA9 gene

carbonic anhydrase family


Input: The exon-intron distribution of Cdebp appears strikingly similar to that of the App gene in the regions encoding the conserved domains, with a divergent structure in the other parts.

Cdebp

App gene


Input: DNA sequence analysis reveals that the gene encodes a protein highly homologous to rat CRP1.

rat CRP1


Input: The gene was expressed as an approximately 1. 5-kb mRNA in most nonlymphoid human cells/tissues including prostate, lung, liver, and colon.


Input: Both of these domains have striking sequence homology with human SIM and Drosophila SIM proteins.

SIM

SIM


Input: We have obtained the human EP4 receptor gene sequence and determined its structure relative to EP4R cDNA synthesized from peripheral blood lymphocytes.

human EP4 receptor gene sequence

EP4R cDNA


Input: Some users will willingly comply with management measures, other users will comply in response to education, but there will be another group who will only respond to enforcement activities.


Input: Three separate activation subdomains, and one negative-acting region, which function in yeast were located in the carboxyl-terminal region of NIT4.


Input: The front (F) interaction occurs ahead of the growing end of RNA.


Input: Collectively, these data indicate that HIP is a membrane-associated HP-binding protein expressed on the surface of normal human uterine epithelia and uterine epithelial cell lines.

HIP

HP-binding protein


Input: The corresponding gene was identified in the GenBankTM data base by sequence alignment and termed RPS30A.


Input: The location of multiple GRK2 and GRK5 phosphoacceptor sites at the extreme carboxyl terminus of the beta2AR is highly reminiscent of GRK1-mediated phosphorylation of rhodopsin.

GRK5 phosphoacceptor sites

rhodopsin


Input: This regulation could not be appreciably modified by enhanced expression of STAT proteins.

STAT proteins


Input: Receptors for interleukin (IL)-10 and IL-6-type cytokines use similar signaling mechanisms for inducing transcription through IL-6 response elements.

interleukin (IL)-10

IL-6-type cytokines


Input: Specifically, the deduced FR-19 amino acid sequence has approximately89, 77, and 68% overall identity to chicken TEF-1A, mouse TEF-1, and mouse embryonic TEA domain-containing factor, respectively.

FR-19 amino acid sequence

chicken TEF-1A

mouse TEF-1

mouse embryonic TEA domain-containing factor


Input: The receptor for hyaluronan mediated motility (RHAMM) gene expression is markedly elevated in fibrosarcomas exposed to transforming growth factor-beta1 (TGF-beta1).

receptor for hyaluronan mediated motility (RHAMM) gene

transforming growth factor-beta1


Input: Oncogenic Raf-1 activates p70 S6 kinase via a mitogen-activated protein kinase-independent pathway.

Oncogenic Raf-1

p70 S6 kinase

mitogen-activated protein kinase


Input: Hydropathy analysis of KCC1 indicates structural homology to NKCC, including 12 transmembrane domains, a large extracellular loop with potential N-linked glycosylation sites, and cytoplasmic N-and C-terminal regions.

NKCC


Input: This protein with a hydrophobic amino terminus appears to be a secreted protein.


Input: Notably, SRF has been found to be a key regulator of members of a class of cellular response genes termed immediate-early genes (IEGs), many of which are believed to be involved in regulating cell growth and differentiation.

SRF

immediate-early genes

IEGs


Input: The final sigma54-dependent DmpR activator regulates transcription of the dmp operon that encodes the enzymes for catabolism of (methyl) phenols.

sigma54-dependent DmpR activator

dmp operon


Input: In this study, we have cloned the human DSG3 gene and examined the transcriptional regulation of its expression.

human DSG3 gene


Input: Clinical evaluation of the Allergan Humphrey 500 autorefractor and the Nidek AR-1000 autorefractor.


Input: None of the five proprotein processing proteases tested were capable of cleaving human pro-LPH, strongly suggesting that they are not involved in the maturation of this enzyme.

human pro-LPH


Input: These changes may be the result of, on the one hand, an increased sensitivity of the neuromuscular transmission and/or decreased muscle contractility and, on the other hand, the result of a reduced plasma clearance during hypothermia.


Input: By using interleukin-3-dependent cells that ectopically express the three ErbB proteins or their combinations, we found that ErbB-3 is devoid of any biological activity but both ErbB-1 and ErbB-2 can reconstitute its extremely potent mitogenic activity.

ErbB proteins


Input: ZIOS was significantly more sensitive than all subsequent methods, and Ptc, O2 was significantly more sensitive than FEV1.


Input: These findings suggest that direct cDNA mapping using fluorescence in situ hybridization provides an accurate and rapid approach to the definition of a transcribed map of the human genome.


Input: YAC and cosmid contigs spanning the Batten disease (CLN3) region at 16p12. 1-p11. 2.

Batten disease


Input: Isolation of a near full-length cDNA from a human fetal brain cDNA library revealed a protein serine-threonine phosphatase with a tetratricopeptide motif, almost identical to human PPP5C (PP5) and highly homologous to rat PPT.

protein serine-threonine phosphatase

human PPP5C

rat PPT


Input: Ly-49 is a family type II transmembrane proteins encoded by a gene cluster on murine chromosome 6.

family type II transmembrane proteins


Input: The Dox-A2 ORF driven by the TDH3 promoter complemented the phenotype of a strain deleted for sun2.

Dox-A2 ORF

TDH3 promoter


Input: The introduction of hARF4 to the cells maintained the balance between cytosolic and membrane-associated Sec7p pools.


Input: Vacuolar membrane vesicles from hum1 mutants lack all Ca2 +/H + antiport activity, demonstrating that Hum1p catalyzes the exchange of Ca2 + for H + across the yeast vacuolar membrane.

hum1 mutants


Input: Detailed mutagenesis of the element' s rare-codon/AU-rich sequence boundary revealed that the destabilizing activity of the MATalpha1 IE is observed when the terminal codon of the element' s rare-codon interval is translated.

MATalpha1 IE


Input: FTF is also abundantly expressed in the pancreas and may exert differentiation functions in endodermal sublineages, similar to SF-1 in steroidogenic tissues.

FTF


Input: The incidence of cardiac death (one per group), Q wave MI (propofol, n = 7; midazolam, n = 3; P = 0. 27), or non Q wave MI (propofol, n = 16; midazolam, n = 18; P = 0. 81) did not differ between treatment groups.


Input: Cluster formation of E-cadherin on the cell surface is believed to be of major importance for cell-cell adhesion.

E-cadherin


Input: DNA polymerase E, DNA ligase III and a DNA structure-specific endonuclease co-purify with the five polypeptide complex.

DNA polymerase E

DNA ligase III


Input: By using reporter gene constructs, it is shown that upstream sequences of the P1 promoter contain several regions that modulate the expression either positively or negatively.


Input: The factor structure of " schizotypal' traits: a large replication study.


Input: Interestingly, however, it is homologous to several expressed sequence tags (EST) of unknown function from Caenorhabditis elegans, Oryza sativa and Homo sapiens.


Input: RESULTS: The bilinear model provided a significantly better fit to the acuity outcome data.


Input: Outcome of severe congenital hypothyroidism.


Input: Nonreturn rates can be used to derive more elementary biological measures for reproductive efficiency, such as conception rate and calving rate, which separately might be more reliable than nonreturn rate itself to evaluate the fertility of a bull or the performance of an AI technician.


Input: However, if EMPD involves the glans penis or perianal area, a search for internal malignancy is still warranted.


Input: The mean values of protease activity were significantly higher in the test groups than in the control group at baseline.


Input: Each half molecule contains four disulfide linkages and four cis peptides.


Input: Only fully processed Pra (N0 and Nb) and ICP35 (ICP35 e, f) are present in B capsids, which are believed to be precursors of mature virions.

Pra

ICP35 e, f


Input: However, one 3' splice site, located at nucleotide (nt) 3225, is used for the processing of most BPV-1 pre-mRNAs in BPV-1-transformed C127 cells and at early to intermediate times in productively infected warts.


Input: Here, the cloning and characterization of S-RNase genes from two species of Rosaceae, apple (Malus x domestica) and Japanese pear (Pyrus serotina) is described and these sequences are compared with those of other T2-type RNases.

S-RNase genes

T2-type RNases


Input: A phylogenetic tree of members of the T2/S-RNase superfamily in plants was obtained.

T2/S-RNase superfamily


Input: In a Hoosier Oncology Group randomized study involving extensive-disease SCLC patients, VIP was superior to etoposide/cisplatin with regard to median time to progression (6. 6 v 5. 8 months), median survival times (9. 1 v 7. 3 months), and 2-and 3-year survival rates (13% v 5% and 5% v 0%, respectively).


Input: It was shown that administration of immunomodulator neurotropin (NSP) results in more steady consolidation and retention of feeding and avoidance behavior, and some neurophysiological mechanisms of that phenomena were revealed.

neurotropin

NSP


Input: Sestamibi scintigraphy, performed in 70 patients, was less sensitive than ultrasonography (80%).


Input: Atopic allergy and other hypersensitivities.


Input: After 6 h of reperfusion, PO2/FlO2 ratio was significantly better after Combined Therapy (372 +/-52 mm Hg) than in the Recipient Instilled (117 +/-47 mm Hg) and Control groups (87 +/-26 mm Hg), with intermediate values in Donor Aerosol dogs (232 +/-64 mm Hg).


Input: The euglobulin clot lysis time was slightly longer in the smokers than in the non-smokers in all three experimental situations, but the differences were not significant.

euglobulin


Input: HS inducibility required the HSE which was bound by HS transcription factor-1 (HSF-1) present in extracts prepared from cells exposed to HS.

HS transcription factor-1


Input: Although the DSK2-1 mutation alters a conserved residue in the Dsk2p ubiquitin-like domain, we detect no differences in Dsk2p or Cdc31p stability.

DSK2-1 mutation

Dsk2p ubiquitin-like domain


Input: Consistent with this interpretation, recombinant CREB and activating transcription factor proteins bound the junB CRE-like site, but did not interact with a mutant CRE-like site.

recombinant CREB

activating transcription factor proteins

junB


Input: Collectively, these results suggest that components of the protein kinase A signaling pathway are recruited by mIg to induce junB transcription.

protein kinase A

mIg

junB


Input: Immunofluorescence microscopy revealed extensive deposition of such extracellular matrices as type IV collagen and laminin in the vascular wall.

type IV collagen

laminin


Input: OBJECTIVE: To compare pregnancy complications in women having genetic amniocentesis at 11-14 weeks versus those undergoing amniocentesis at 16-19 weeks' gestation.


Input: Three ORFs (9765orfR002, 9765orfR011 and 9765orfR013) were found to be homologous with Schizosaccharomyces pombe polyadenylate binding protein, Escherichia coli hypothetical 38. 1-kDa protein in the BCR 5' region, and transcription regulatory protein Swi3, respectively.

polyadenylate binding protein

BCR


Input: Two new flavone glucosides, nevadensin 5-O-beta-D-glucoside and nevadensin 5-O-beta-D-glucosyl (1--> 6) beta-D-glucoside, have been isolated from the aerial parts of Lysionotus pauciflorus.


Input: Recently, our laboratory developed a screen that identified five multicopy suppressors that can rescue lethal strains of clathrin heavy chain-deficient yeast (Chc-scd1-i) to viability.

clathrin

Chc


Input: Reproductive period affects water intake in heat-stressed dehydrated goats.


Input: The logistic regression analysis of the manual method (percentage normal morphology) and IVOS indicated that both were predictors of fertilization.


Input: METHODS: Rats received continuous intragastric infusion of elemental diet or with supplementation of oatbase, Lactobacillus reuteri R2LC, and Lactobacillus plantarum DSM 9843, with and without fermentation, from the beginning of the study.


Input: However, D8 binding was observed by nuclease protection with lactotroph-as well as somatotroph-like cell nuclear protein.

lactotroph-as well as somatotroph-like cell nuclear protein


Input: The ability of A20 to block NF-kappaB activation was mapped to its C-terminal zinc finger domain.

NF-kappaB


Input: By using a DNA sequence selected for its ability to bind recombinant BCL-6 in vitro, we show here that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines.

recombinant BCL-6


Input: The predictive value of a positive flag was 77. 7%.


Input: Because chromosome X is frequently involved in structural alterations in neoplastic Syrian hamster cells transformed by chemical carcinogens and oncogenic viruses, the localization of the cph locus on this chromosome supports the notion that the cph oncogene plays a role in the malignant conversion of chemically transformed hamster fibroblasts.

cph locus

cph oncogene


Input: Gap1 (IP4BP), one of a member of Ras GTPase-activating proteins, has been identified as a specific inositol 1, 3, 4, 5-tetrakisphosphate (IP4)-binding protein (Cullen, P.

Gap1 (IP4BP)

Ras GTPase-activating proteins

inositol 1, 3, 4, 5-tetrakisphosphate (IP4)-binding protein


Input: We previously described the purification of an 83-kDa phosphatidic acid phosphatase (PAP) from the porcine thymus membranes (Kanoh, H., Imai, S.-i., Yamada, K. and Sakane, F. (1992) J.

83-kDa phosphatidic acid phosphatase

PAP


Input: A cDNA encoding the amino-terminal 17% of apoB (apoB17) was fused to a cDNA coding for the last 37 amino acids of decay-accelerating factor (DAF), which contains the signal for glycosylphosphatidylinositol anchor attachment.

apoB

decay-accelerating factor

DAF


Input: Next, we stably overexpressed wild-type Shc or Y317F mutant Shc into HIRc cells.

wild-type Shc

Y317F mutant Shc


Input: The small GTPase Rho is implicated in physiological functions associated with actin-myosin filaments such as cytokinesis, cell motility, and smooth muscle contraction.

small GTPase Rho

actin

myosin


Input: Conversely, activation of this signaling pathway by expression of a constitutively active MKK1 mutant dramatically increased cyclin D1 promoter activity and cyclin D1 protein expression, in a growth factor-independent manner.

MKK1 mutant

cyclin D1

cyclin D1 protein


Input: Furthermore, upstream insertion of the GSTP1 silencer element failed to inhibit activity of a heterologous promoter in MCF7 cells.

GSTP1 silencer element


Input: In order to delineate structural motifs regulating substrate affinity and recognition for the human dopamine transporter (DAT), we assessed [3H] dopamine uptake kinetics and [3H] CFT binding characteristics of COS-7 cells transiently expressing mutant DATs in which the COOH terminus was truncated or substituted.

human dopamine transporter

DAT

mutant DATs


Input: An expression library was constructed by inserting 5' portion-enriched cDNAs from phytohemagglutinin-stimulated peripheral blood mononuclear cells into upstream of signal sequence-deleted CD4 cDNA in an Epstein-Barr virus shuttle vector.

phytohemagglutinin

signal sequence-deleted CD4 cDNA


Input: Radiolabeled recombinant TARC specifically bound to T cell lines and peripheral T cells but not to monocytes or granulocytes.

recombinant TARC


Input: Therefore, we have identified a cis-acting element, the E1 E-box, located in the GAP-43 promoter region that modulates either positively or negatively the expression of the GAP-43 gene depending on which E-box-binding proteins occupy this site.

GAP-43 gene

E-box-binding proteins


Input: Collectively, our findings demonstrate that SF-1 plays a key role in controlling the basal and cAMP-stimulated expression of the StAR gene.

StAR gene


Input: Using one of the six fragments (CPK3-8), we isolated a 2022 bp cDNA (VrCDPK-1) from a Vigna radiata lambda gt11 library.

2022 bp cDNA (VrCDPK-1)


Input: However, in TF-1 cells grown on GM-CSF before starvation, CREB phosphorylation was observed 10 minutes after PIXY321 stimulation.

GM-CSF

CREB


Input: Workplace violence--nurses at risk.


Input: RESULTS: The LV maximum brightness and area under the curve showed significant negative correlations (p = < 0. 004) with the FIO2, while the minimum brightness showed a significant positive correlation (p = < 0. 002).


Input: The results also imply that the absence of perforin expression in non-cytotoxic cells may be due to the suppression of the induction of the killer-cell-specific trans-acting factor NF-P2.

perforin


Input: We identify considerable spatio-temporal similarities between reported expression patterns of Ypr10 genes and ribonuclease genes, which, together with the significant sequence similarity to the ginseng ribonuclease, support the hypothesis of a ribonuclease function for PR-10 proteins and allow the prediction of possible biological roles.

Ypr10 genes

ginseng ribonuclease

PR-10 proteins


Input: The expression of ERV3 env mRNA was found to be differentiation-associated, with high expression detected in the late stages of monocytic development.

ERV3 env mRNA


Input: Initial estimates indicate that 27, 193 people are either in receipt of or in need of mental handicap services.


Input: It is exclusively observed in smooth muscle cells by Northern blotting and immunohistochemical analysis and therefore designated " smoothelin. " A human smooth muscle cDNA library was screened with the monoclonal antibody R4A, and a full-size cDNA of the protein was selected.

" smoothelin. "

monoclonal antibody R4A


Input: Concurrent with ligand-dependent uptake, we now show that the receptor undergoes ligand-induced ubiquitination, suggesting that receptor ubiquitination may function in the ligand-dependent endocytosis of the a-factor receptor as well as in its constitutive endocytosis.

a-factor receptor


Input: Epstein-Barr virus nuclear protein 2 (EBNA2) binds to a component of the human SNF-SWI complex, hSNF5/Ini1.

Epstein-Barr virus nuclear protein 2

SNF

SWI


Input: Our studies also excluded the possibility that the phosphorylation of Ser-2, Ser-123, or Ser-210, had roles in the trans-suppression activity of the large HDAg, in the assembly of empty virus-like HDAg particle, and in the nuclear transport of HDAgs.

large HDAg

virus-like HDAg particle

HDAgs


Input: Homologous recombination between the Autographa californica nuclear polyhedrosis virus (AcNPV) genome and a 0. 6-kbp-long DNA fragment derived from the putative DNA helicase gene of Bombyx mori nuclear polyhedrosis virus generates eh2-AcNPV, an expanded-host-range AcNPV mutant (S.

DNA helicase gene of Bombyx mori nuclear polyhedrosis virus


Input: The data further indicate that the IL-7R alpha chains are directly involved in the activation of JAKs and STATs and have a major role in proliferative signaling in precursor B cells.

IL-7R alpha chains

JAKs

STATs


Input: Furthermore, the potency of Dacarbacine in the treatment of carcinoid tumors seems to be underestimated up to now.


Input: 5) We' ve noticed that the mean value of the cost for episode of pnx s. in class A was more than 15% compared to class B and the cost for patient in class A was nearly double than in class B.


Input: Cbl constitutively interacts with the SH3 domains of Grb2, with a preference for the amino-terminal domain, and is in this way recruited to Shc upon BCR stimulation.

Cbl

SH3 domains

Shc

BCR


Input: Activation mediated by Cat8p was no longer detectable in a cat1 mutant.

cat1 mutant


Input: Treatment is instituted with prednisone and cyclophosphamide.


Input: Laboratory evaluation was normal, and neuroimaging failed to confirm obstruction of venous or lymphatic drainage.


Input: Microcomputer management of chronic hepatitis B virus asymptomatic patients


Input: While fusion to the N-terminus required a linker to become surface accessible, both fusion to the N-terminus and to the C-terminus was compatible with particle assembly and preserved the native antigenicity and immunogenicity of HBcAg.

HBcAg


Input: The standard dosage of anti-D currently given at all gestational ages is 1 ampoule containing 125 micrograms of anti-D.

anti-D

anti-D


Input: We report here the molecular cloning of a putative adhesive molecule from P. falciparum that shares both sequence and structural similarities with a sporozoite surface molecule from Plasmodium termed the thrombospondin-related anonymous protein (TRAP) and, to a lesser extent, with the circumsporozoite (CS) protein.

thrombospondin-related anonymous protein

TRAP

circumsporozoite (CS) protein


Input: There are no introns within the gene, which contains a 9360-bp open reading frame and encodes a 377-kDa protein.


Input: METHODS: DSF was instilled in one eye chosen at random and CF in the fellow eye of 13 normal subjects and in 13 patients with KCS.


Input: CONCLUSION: The results demonstrate that at the site of lumbar disc herniation, inflammatory cytokines such as interleukin-1 alpha are produced, which increases prostaglandin E2 production.

interleukin-1 alpha


Input: The predominant sensitizing allergens in Swedish asthmatic children are furred pet animals.


Input: Our results demonstrate that distinct cytoplasmic domains of these cytokine receptors elicit convergent signaling pathways and provide evidence that beta c and IL-2R beta function as a complete signal transducer.

beta c

IL-2R beta


Input: In addition, they display common features that make them strikingly related to snoRNA U14.

snoRNA U14


Input: U24 has two separate 12 nt long complementarities to a highly conserved tract of 28S rRNA.

28S rRNA


Input: This complex interacts at the GTPase domain in the large subunit rRNA, overlapping the binding site of the protein L11-like eukaryotic counterpart (Saccharomyces cerevisiae protein L15 and mammalian protein L12).

GTPase domain

protein L11-like eukaryotic counterpart

Saccharomyces cerevisiae protein L15

mammalian protein L12


Input: Chromatin repression of these replacement genes would be avoided, consistent with the high, constitutive expression of replacement H3 histone genes in plants.

H3 histone genes


Input: This transition is regulated positively by G1-specific cyclin-dependent kinases (cdks) and negatively by the product of the retinoblastoma tumour suppressor gene, pRb.

G1-specific cyclin-dependent kinases

cdks

retinoblastoma tumour suppressor gene

pRb


Input: To derive quantitative concentration changes from measurements of light attenuation, the optical path length must be known.


Input: STUDY DESIGN.


Input: Following the injection of PGF2 alpha, heifers were observed visually for signs of estrus at 0730 and 1630 (45 min each).


Input: Differential activation of the extracellular signal-regulated kinase, Jun kinase and Janus kinase-Stat pathways by oncostatin M and basic fibroblast growth factor in AIDS-derived Kaposi' s sarcoma cells.

extracellular signal-regulated kinase

Jun kinase

Janus kinase

Stat

oncostatin M

basic fibroblast growth factor


Input: There is general agreement that the hepatitis C virus is efficiently transmitted parenterally, while data on viral transmission from mothers to babies or by sexual or non-sexual household contact are conflicting.


Input: Ten weeks after reconstruction, the regenerating nerves already resembled normal nerves.


Input: The distribution and organization of projections from the spinal cervical enlargement to subnucleus reticularis dorsalis (SRD) and the neighbouring Cuneate nucleus (Cu) area was studied in the rat by using microinjections of Phaseolus vulgaris leucoagglutinin (PHA-L) into different laminae around the C7 level.

Phaseolus vulgaris leucoagglutinin

PHA-L


Input: The levels of fibrinogen as well as antithrombin III (ATIII) and heparin cofactor II (HCII) activities were steadily increased in loop-bearing animals.

fibrinogen

antithrombin III

ATIII

heparin cofactor II

HCII


Input: Amplification and overexpression of the c-erbB-2 gene in 21MT-2 and 21MT-1 human breast carcinoma cells results in progressively elevated levels of constitutively tyrosine-phosphorylated p185erbB-2 and is associated with progressive insulin-like growth factor (IGF) and combined IGF/epidermal growth factor (EGF) independence in culture.

c-erbB-2 gene

tyrosine-phosphorylated p185erbB-2

insulin-like growth factor

IGF

IGF

epidermal growth factor

EGF


Input: Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant, neuromuscular disorder characterized by progressive weakness of muscles in the face, shoulder and upper arm.


Input: The mature chromosome 4 FRG1 transcript is 1042 bp in length and contains nine exons which encode a putative protein of 258 amino acid residues.

FRG1 transcript


Input: Patients who have undergone thyroidectomy for thyroid carcinoma are frequently subjected to periods of induced severe hypothyroidism in preparation for 131I whole body scanning and measurement of serum TG.

TG


Input: Full thyroid function testing was performed on 600 randomly selected samples with normal TSH values and also on subjects with abnormal TSH levels.

TSH

TSH


Input: In a third experiment, crossover AM between dissimilar textures was investigated, and it was found that the more salient textures carried the AM.


Input: The relative tumor FDG-uptake (Q-MRGlu) (tumor/contralateral cortex) of all meningiomas was calculated with 0. 73 +/-0. 37 (0. 24-1. 79).


Input: Zatebradine weakly depressed the ectopic ventricular rate but not the arrhythmic ratio of the ventricular arrhythmias induced by two-stage coronary ligation 24 h after the ligation in conscious dogs.


Input: Catha edulis, a plant that has amphetamine effects.


Input: The predicted protein, Seb1p, consists of 82 amino acids and contains one potential membrane-spanning region at the C-terminus but no N-terminal signal sequence.


Input: The SEB1 homologue thus isolated, SEB2, encodes a protein 53% identical to Seb1p.


Input: Nonetheless, that ventricular afferents, in certain special settings, are able to induce e. g. generalised vasodilation and hypotension cannot be excluded.


Input: Large ones were similar in size to the main lobe and small ones were approximately 1/4 of the length of the main lobe.


Input: Fragments and analogs of the hormone ACTH were previously shown to have beneficial effect on the outcome of head injury, while elevated levels of corticosterone (CS) exacerbate it.

ACTH


Input: Fifty-one patients with primary refractory or relapsed malignant lymphoma (47 non-Hodgkin' s lymphoma and four Hodgkin' s disease) were treated with a new chemotherapeutic regimen (cisplatinum, methyl GAG, bleomocyin, methyl prednisolon).


Input: With the increasing use of ACE inhibitors, the incidence of rare adverse effects such as potentially lethal pancreatitis is likely to increase.

ACE


Input: In 3 treatments the diet was supplemented with 0, 100 and 150 mg probiotic/kg food.


Input: Low-dose aspirin and recurrent miscarriage.


Input: Protein films are distinctly different in mechanical profiles from those films made of other materials.


Input: Furthermore, cpxA * mutations suppress the toxicity conferred by the LamB-LacZ hybrid protein, which exerts its effects in the cytoplasm, sequestered from DegP.

cpxA *

LamB

LacZ

DegP


Input: The PI3K _ 68D cDNA encodes a protein of 210 kDa, which lacks sequences implicated in linking p110 PI 3-kinases to p85 adaptor proteins, but contains an amino-terminal proline-rich sequence, which could bind to SH3 domains, and a carboxy-terminal C2 domain.

PI3K _ 68D cDNA

p110 PI 3-kinases

p85 adaptor proteins

SH3 domains


Input: AIMS/METHODS: Reticuloendothelial system function, as assessed by clearance of radiolabelled bacteria, was evaluated in acute liver injury induced by D-galactosamine in rats, and compared with that after 70% liver resection model.


Input: Our laboratory and others have shown alternative splicing of up to ten exons at a discrete extracellular site to be primarily responsible for the generation of CD44 variant (CD44v) isoforms.

CD44 variant


Input: Study groups were control, and those treated with the alpha1-adrenoceptor-subtype blockers WB4101 (0. 5 mg/kg i. v.) or chloroethylclonidine (1. 9 mg/kg i. v.).


Input: This caused severe cortical damage and neuronal loss in hippocampus subfields CA1, CA3, and hilus.


Input: The occurrence of multiple malignancy was studied in 674 patients with hematologic malignancies who were admitted to this department during the past 10 years.


Input: The upTRE binds more T3R homodimers and less T3R-RXR heterodimers than the dnTRE, and T3 more readily facilitates heterodimer binding to the dn-than to the upTRE.

T3R homodimers

RXR


Input: Transcriptional control of a nuclear gene encoding a mitochondrial fatty acid oxidation enzyme in transgenic mice: role for nuclear receptors in cardiac and brown adipose expression.


Input: Hoeben, F. J.


Input: Moreover, glucan synthase activity, which is activated by Rho1p, was significantly reduced in the deltabem4 mutant.

glucan synthase

deltabem4 mutant


Input: In gel retardation assays, an RCS cell-specific protein and another closely related protein expressed only in RCS cells and primary chondrocytes bound to a 10-bp sequence within the 18-mer.


Input: Two classes of Xanthomonas pathogens evading Bs2 host resistance and displaying reduced fitness were found to be specifically mutated in avrBs2.


Input: Thus, the characterization of the promoter region should help to define regulatory elements that control neuron-specific and developmental expression of the MAP1B gene.

MAP1B gene


Input: Mutants lacking the 3' stem-loop exhibited a 75% reduction in the level of psaB mRNA.

psaB


Input: The deduced amino acid sequence was highly conserved across the wide range of eukaryotes (vertebrates, invertebrates, fungi, plants and protozoa) in which this gene has now been identified.


Input: Semidominant mutations in the yeast Rad51 protein and their relationships with the Srs2 helicase.

yeast Rad51 protein

Srs2 helicase


Input: Alterations of the 5q23-q31 interval are frequently observed in myelodysplasia and myeloid leukemia.


Input: Previous studies have suggested that the 616 amino acid, 70-kDa subunit of RPA (RPA 70) is composed of multiple structural/functional domains.

70-kDa subunit of RPA

RPA 70


Input: Neurons were held at-67 mV to equate voltage-dependent effects.


Input: This site acts as a negative element when transferred to the thymidine kinase promoter, but does not confer inducibility.

thymidine kinase promoter


Input: The extent of the fbpA operator sequence (42 bp), as defined by our footprinting analysis, would suggest the binding of two Fur repressor dimers.

fbpA operator sequence (42 bp)

Fur repressor dimers


Input: The structural similarity between Vav and other guanine nucleotide exchange factors for small GTP-binding proteins, together with the recent identification of biochemical routes specific for members of the Ras and Rho family of GTPases, prompted us to explore whether MAPK or JNK are downstream components of the Vav signaling pathways.

Vav

guanine nucleotide exchange factors

small GTP-binding proteins

Ras

Rho family

GTPases

MAPK

JNK

Vav


Input: CONCLUSION: Twice daily treatment with inhaled fluticasone propionate 50 micrograms or 100 micrograms was significantly more effective than theophylline in the treatment of mild-to-moderate asthma.


Input: Our results support a model where both E2F-and CDE-mediated repression, acting at different stages in the cell cycle, are dependent on promoter-specific CHR elements.


Input: The cDNA clone was used as a homologous probe to isolate a truncated genomic clone encoding H2A1.


Input: Comparison of the deduced amino acid sequences with protein sequences of T. pyriformis H2As showed only two and three differences respectively, in a total of 137 amino acids for H2A1, and 132 amino acids for H2A2, indicating the two genes arose before the divergence of these two species.


Input: Cognitive visual dysfunction in a child with cerebral damage.


Input: Interaction was apparently determined by the N-terminal splice region of RPDE-6, as the PDE4A splice variant RPDE-39, which differs from RPDE-6 at the extreme N-terminus, failed to associate with v-Src-SH3; met26RD1 (where RD1 is rat' dunc-like' PDE), which has the N-terminal splice region deleted, failed to associate with v-Src-SH3, and the association of RPDE-6 and v-Src-SH3 was blocked by a fusion protein formed from the N-terminal splice region.

v-Src

rat' dunc-like' PDE

v-Src

v-Src


Input: Potentially load-insensitive measures of ventricular performance were therefore evaluated in 10 open-and closed-chested, anesthetized rabbits.


Input: Large strain differences were found for all variables recorded, i. e., the proportion of attacking males, the time spent in the brightly lit box, and the number of transitions between the lit and the dark boxes.


Input: It is the oxidation peak of this product, arising in acidic media at 0. 42 V, which was analysed using DPV, again following the accumulation of clenbuterol at the Nafion-modified CPE.


Input: Phenylephrine is a pure alpha-1 adrenoreceptor agonist known to produce marked systemic vasoconstriction and associated hypertension with occasional profound reflex bradycardia.

alpha-1 adrenoreceptor


Input: The expression of the first two genes located in this unit (c-gvpD and c-gvpE) was also monitored by Western blot (immunoblot) analyses using antisera raised against these proteins synthesized in Escherichia coli.

c-gvpD

c-gvpE


Input: One unit encodes traA, traF, and traB, while the second encodes traC, traD, and traG.

traA

traF

traB

traC

traD

traG


Input: A.


Input: In an effort to isolate genes with down-regulated expression at the mRNA level during oncogenic transformation of human mammary epithelial cells (MECs), we performed subtractive hybridization between normal MEC strain 76N and its radiation-transformed tumorigenic derivative 76R-30.