Input: Static lung function in puppies after pneumonectomy.


Input: Bilateral Charnley arthroplasty as a single procedure.


Input: The relationship between estrogenic properties of Tamoxifen and breast cancer management is discussed.


Input: A fluoroimmunoassay for the determination of serum of plasma levels of propranolol was developed using antibodies to propranolol coupled to magnetizable solid-phase particles and fluorescein-labeled propranolol as tracer.


Input: The syncytial microvillous projections seemed to be more numerous and longer in CNF, otherwise the structure of the trophoblastic layer of the villi and the lining of the subtrophoblastic vessels were identical in CNF and controls.


Input: When pollen allergen from three grass species were used, The RAST-test results did not differ from duplicate values either.


Input: DMI and 2-OH-DMI concentrations were determined in a similar group of 61 DMI-treated patients.


Input: It has been shown in experiments in vitro that the hepatotrophic organic anions, the radiographic contrast agent (RCA) bilignost used in cholecystography and Bengal pink, have an affinity, unlike the urographic RCA triombrin and renotrophic dye indigo-carmine, for the plasmatic membranes (PM) of liver cells.


Input: 33 out of 90 neurons of the cat medial geniculate body revealed the selectivity of their afterdischarges to movement of sound when velocity of the movement changed from 30 to 180 deg/s.


Input: In controls, only modest differences were observed.


Input: Assay of serum immunoreactive trypsin in dried blood spots and the early detection of cystic fibrosis.

serum immunoreactive trypsin


Input: Similar waves were seen on cross-correlating a motor unit with an electronic oscillator, confirming that their occurrence does not necessarily demonstrate the existence of active neural interactions.


Input: Leukocyte enzyme activity and blood lymphocyte blast transformation in chronic bronchitis


Input: In literature, the HBE has been displayed by application of the averaging method.


Input: Forty-five cases were surgically by direct approach to the tumour, while two cases were treated only with a shunt.


Input: In Group V, the salvaged tissue was primarily subepicardial with virtually no lateral zone of salvaged tissue (ratio of salvaged subepicardium to salvaged subendocardium 14. 8 +/-1. 9 to 1).


Input: Progressive 100-mmHg stepwise decreases in superfusate oxygen partial pressure (PO2) from control (95% O2 aeration, PO2, 620-650 mmHg) were produced, and subsequent changes in isometric active and resting tension were measured.


Input: The known B1-deficiency reaches excessive high values with light exercise.


Input: Based on AUC infinity analyses, the pharmacokinetics of buflomedil were found to be linear within the dose ranges studied (50 to 200 mg for i. v. injection and 150 to 450 mg for oral administration).


Input: Gastrin secretion during food stimulation in digestive system diseases

Gastrin


Input: Fibrinogen determination using the KZM-1 meter

Fibrinogen


Input: Delayed or paradoxically emptying regions of the left ventricle were detected by a relatively new nuclear technique--phase imaging.


Input: Responses to brainstem of nuclei medialis dorsalis, lateralis posterior were of considerably longer latency.


Input: Nineteen patients with non-visualized gallbladder with OCG subsequently had Tc-99m-PyG cholescintigraphy performed.


Input: One was allowed fresh drinking water ad libitum whilst the other received Aludrox in their drinking water.


Input: Anamnestic data were obtained from case history, smoking habits were not known in collective A and C.


Input: The determination of physical performance capacity was based on W170, W85% and on predicted VO2 max measured with continuously increasing work load on a bicycle ergometer.


Input: Determination of lead in blood.


Input: Effect of indomethacin and prostaglandin F2 alpha on parturition in swine.


Input: LD50 values of terms of KP were 84 mg/kg in male rats and 122 mg/kg in female rats when KP-CMC was administered intrarectally, and 117 mg/kg in male and 92 mg/kg in female when KP-T10 was administered intrarectally., while peroral administration of KP-CMC showed LD50 values of 68 mg/kg in males and 78 mg/kg in females in terms of KP.


Input: Autotransfusion was performed as follows: Heparin-ACD-B-Heparin-DPD-Heparin-ACD-B etc.


Input: Generally the differences between short gut and sham operation animals disappeared when the data were normalised for mucosal weight.


Input: A simplified thin-layer chromatographic determination of hippuric acid and methylhippuric acids.


Input: The architecture of microvasculature in these two regions was also examined by scanning electron microscopy, using the resin casting method.


Input: MSMS Council hears new public health director.


Input: Chordoma of the spinal cord in a F344 rat.


Input: Micro high-performance liquid chromatographic system with micro precolumn and dual electrochemical detector for direct injection analysis of catecholamines in body fluids.


Input: A narrow zone of myelin-axonal dissociation was also observed.


Input: The IgA deficiency is combined with the IgE one.

IgA

IgE


Input: In PB mice, there was only a small deficit in the number of the hippocampal pyramidal neurons compared to controls (15%, p less than 0. 01), and no deficit in the granule cells.


Input: Nutritional cataracts in timber wolves.


Input: The quantitative determination of HBSAG--a valuable aid in evaluating the infectiousness of hepatitis B virus carriers

HBSAG


Input: 2. numerous narrow shunt vessels departing continuously from the primary arteries to feed a secondary arterial system which parallels the primary one.


Input: Urological complications are frequent during and after the treatment of gynecological malignancy.


Input: Arachnoid cyst.


Input: Hypotension was produced by head up tilt.


Input: Therefore the procedure of Lich-Gregoir is not to be recommended in adults.


Input: Mucoepidermoid and acinous cell carcinomas of salivary tissues.


Input: Twenty patients aged 45 or older with the diagnosis of endogenous depression were evaluated in terms of safety and efficacy in their response to multiple monitored electroconvulsive therapy (MMECT) versus single electroconvulsive therapy (SECT).


Input: Longitudinal force-length relationships of guinea pig ureter were studied in vitro in animals 3 weeks, 3 months, and 3 years of age.


Input: Tests of the method indicate (1) the Mossbauer source can be placed on the basilar membrane without altering the signal-transmission properties of the cochlea, and (2) the source adheres to the basilar membrane.


Input: Angiographic work-up in a patient with late vaginal metastasis from a renal carcinoma.


Input: The authors conclude that nonspecificity of low platelet MAO as a possible correlate of bipolar affective disorder, as well as schizophrenia, increases the burden of proof necessary before findings of low platelet MAO can be accepted as primary.

platelet MAO

platelet MAO


Input: Ecthyma, a known disease, of which little is known


Input: Estrogen replacement, either as 17 beta-estradiol or beta-estradiol-3-benzoate via subcutaneous Silastic capsules, was associated with elevated rates of heat production and dry heat loss relative to untreated ovariectomized controls.


Input: The following aspects were assessed: (1) The effect on the cardiovascular system in terms of brachial arterial pressure, pulse rate, and oxygen consumption (VO2) during exercise in 5 health volunteers; (2) emg activity of the tibialis anterior and gastrocnemius muscles during exercise in the same 5 volunteers; and (3) postexercise ankle pressure changes in 10 subjects with angiographically proven occlusive arterial diseases of the lower extremities.


Input: It was argued that this arose from the possibility that the nature of blue collar jobs was physical, and that loss of myocardial tissue might be expected to more markedly interfere with their work efficiency (on returning to work) than it would the efficiency of the more sedentary jobs of white collar workers.


Input: Importance of determining the blood sulfhydryl groups in fractures of the long tubular bones complicated by infection


Input: The results revealed increased blood lead level associated with decreased blood haemoglobin and increased urinary excretion of delta amino levulinic acid.

blood haemoglobin


Input: Following iv injection of 0. 5 g galactose per kg body weight, together with 2 mu Ci generally 14C-labelled galactose, 14CO2 is collected in regular intervals during one hour.


Input: Specific clotting factor assays showed an isolated deficiency of factor X ranging from 7 to 12 per cent on three determinations.

factor X


Input: Blood variables measured at eight intervals before, during, and after operation were as follows: seven plasma proteins, free hemoglobin, formed elements, and clotting functions.

hemoglobin


Input: The ability of sodium phenobarbital (60 mg/kg) and sodium barbital (80 mg/kg) to produce a taste aversion in 23 hr fluid deprived rats was examined using a discrimination or two bottle taste aversion task (0. 125% sodium saccharin solution or water).


Input: It appears that the pulmonary gas exchange parenchyma of these smallest mammals is well suited to supply the organism with the comparatively high levels of O2 required by the high metabolic rates, exhibiting a structural adaptation of the lung to higher VO2.


Input: Underestimations by as much as 35% may occur due to the problems in the existing methodologies.


Input: Chemotherapy was administered without altering the course of the disorder.


Input: Drug inhibition of whole blood aspirin esterase.

aspirin esterase


Input: However, at lower temperature the positive staircase was not clear and rather negative staircase appeared (1--3 Hz).


Input: Visual averaged evoked responses and platelet monoamine oxidase in patients suffering from alcoholism.

platelet monoamine oxidase


Input: At the end of the experiment the urinary porphyrin excretion and the porphyrin content in lijver and skin were diminished in HCB-CQ-treated animals by about 50% compared to the HCB controls.


Input: Although stone-formers were not found to display any features of magnesium metabolism that were different from those in the control group, their lower urinary excretion of magnesium in relation to calcium may be a factor in their increased stone-forming propensity.


Input: A 16-year follow-up study of 69 paraplegics with complete lesions from T1-L3 is presented.


Input: Hippocampal stimulation overlapping conditioned stimulus preexposure produced attenuation of latent inhibition, as did stimulation presented during conditioning after preexposure.


Input: The centromedial amygdala and gastric pathology in rats.


Input: Cataract extraction in primary glaucoma


Input: Number and size of the myelin structures in the pneumocytes typ II increased simultaneously.


Input: In the intact animal, postextrasystolic potentiation depended on the basic pacing interval, t0, and the timing of the extrasystole, t1: when t0 was held constant and t1 was increased, potentiation decreased; when t1 was held constant and t0 was increased, potentiation increased.


Input: In spite of this and other complications of corticosteroids, she made a full recovery from the fungal infection following treatment with amphotericin B and surgical excision of the lung abscess.


Input: Implications of this observation for pediatrics are discussed.


Input: For the study of the transition of long to short waves (deep-water waves) a closed-form solution is advantageous; this can, however, only be obtained at the cost of further simplification.


Input: Treatment of suppurative peritonitis


Input: We report a case of pheochromocytoma manifesting during the third trimester of pregnancy.


Input: Fasting plasma and lipoprotein lipid concentrations, adipose tissue lipoprotein lipase activity, anthropometric data, alcohol consumption, smoking habits, weekly mileage run and performance on a bicycle ergometer were recorded before and after the training period.

adipose tissue lipoprotein lipase


Input: The C18: 1: C10 value is a convenient measure of these changes and can be determined more rapidly than determining all the lower fatty acids.


Input: A progressive growth of blood erythrocyte membrane injury has been demonstrated after rats were exposed to gamma-irradiaton at a dose of 100 to 500 Gy.


Input: Within the 3' terminal 50 nucleotides, the mouse mt 12S rRNA contains a potential 10 bp hairpin structure and a sequence of 15 consecutive nucleotides common to the RNA of the small ribosomal subunit in all systems, but does not contain the mRNA binding site (ACCUCC) found in E. coli and corn chloroplast rRNAs.

mouse mt 12S rRNA


Input: Thirty cadaver brains were examined under X 6 to 16 magnification in order to define the microsurgical anatomy of the pineal region, particularly the relationship of the pineal body, posterior cerebral artery, superior cerebellar artery, vein of Galen, basal vein of Rosenthal, internal cerebral vein, straight sinus, bridging vein, the size of the tentorial notch, and the third and the fourth cranial nerves.


Input: Serum antibody titre was not significantly associated with the recurrence rate or the duration of infection.


Input: We propose that refeeding may be an important mechanism for activation of certain viral infections previously suppressed by famine.


Input: One hundred twenty units of deglycerolized red blood cells, some with glycerol added so as to exceed an acceptable 1% glycerol content, had measurements made of the post-wash supernatant fluid by refractive index and osmometry.


Input: The symptoms and objective findings were caused by a malignant lymphoma, and the diagnosis was established from a drill biopsy.


Input: Our study differs from previous studies in that it is limited to one diagnostic entity, yet at the same time evaluates a broad range of social and work-related factors in disability.


Input: It is suggested that a raised hydroxykynurenine/hydroxyanthranilic acid ratio does not necessarily indicate vitamin B6 deficiency but may represent a nonspecific response of tryptophan metabolism to stress.


Input: All control persons had a normal reaction to DNFB.


Input: In a control group both common carotid arteries (CCA) were ligated.


Input: At pH 6. 9, the same lidocaine concentrations significantly reduced resting potential (3-10%), action potential amplitude (3-8%) and Vmax (14-22%).


Input: Simultaneous right and left adrenal and peripheral blood samples were collected for determination of oestrone (E1) and oestradiol (E2).


Input: Arm function tests.


Input: All lambs with B breeding had significantly higher Hb levels at the end of the experiment than did NB lambs. b and S x B lambs had higher (P <. 05) Hb levels than the D x B lambs, and B lambs had the highest (P <. 05) mean corpuscular hemoglobin concentrations.

Hb

Hb

hemoglobin


Input: The same response occurs whether acrylamide is given immediately after nerve ligation or 1 week later.


Input: The operation recommended is excision of 3 mm of central slip followed by end-to-end repair of the tendon.


Input: In the unclipped group arterial pressure decreased 50 mmHg to normal by 24 h and was associated with increased diuresis and a small decrease in blood volume (9. 8%).


Input: Marked sedative activity was observed with 9-methoxy-5-phenylpyrrolo [2, 1-d] [1, 5] benzothiazepin-6, 6-dioxide (NF19) and 9-chloro-5-p-nitrophenylpyrrolo [2, 1-d] [1, 5] benzothiazepin-6, 6-dioxide (NF20).


Input: In patients, the effect of CCK-PZ on the movement of the terminal part of the bile duct was measured with a pressure sensor using a duodenofiberscope.

CCK

PZ


Input: As high-speed, volumetric imaging, computed tomographic scan machines such as the Dynamic Spatial Reconstructor become available with higher density resolution, perhaps a single injection of contrast agent into the right atrium or even a peripheral vein may be adequate to obtain all these measurements.


Input: The ESEG' s are a direct result of the NEXT study.


Input: The potentially SLE-inducing drugs are reviewed.


Input: A third series of mice were given a single injection of 5-OH-DA, sacrificed, and prepared for ultrastructural study.


Input: Fourteen different species (eight Platyhelmintha, one Nematoda and five Crustacea) have been inventorized.


Input: No symptoms other than hot flush showed such significant correlation with plasma epinephrine or norepinephrine levels.


Input: The mean values of the concentrations of the components due to tobacco smoke are: CO = 1. 1 ppm, NO = 32 ppb, NO2 = 24 ppb, nicotine = 0. 9 micrograms/m3, particulate matter = 133 micrograms/m3.


Input: The average backscatter coefficient was six time larger in regions of infarct studied 8--10 weeks after occlusion than that in regions of infarct studied 5--6 weeks after occlusion.


Input: At 4 wk however, tumor relapse was noted in 6 of 7 group 4 responders, 10 of 12 in group 5, 13 of 16 in group 7, but only 4 of 19 group 8 responders (p less than. 001 group 8 versus 4, 5, 7).


Input: Early infection was detected in one of 50 control women who gave birth to a healthy infant.


Input: Pentachlorophenol accelerates the onset of HCB porphyria, in other words it increases the total urinary porphyrin excretion and causes an earlier disturbance of the porphyrin pattern.


Input: Family planning continues to play a minor role, and only 25. 3 per cent of all patients reviewed took to oral contraceptives for shorter or longer periods of time.-The percentages of primiparae and secundiparae in all births as well as the high percentage of multigravidity are parameters by which the approach to reproduction differs substantively from behaviour patterns in Europe.


Input: The term osteomesopycnosis is proposed for a sclerosing bone disease with dominant inheritance that has been discovered in five members of four different families.


Input: The 87K protein, together with proteins of 105, 000 and 75, 000 daltons, are translated from leftward transcribed (1-strand) messenger RNAs that are complementary to the viral genome between positions 11. 2 and 31. 5.


Input: The identification of viable myocardium with both 99mTc-tetrofosmin and 201Tl can be greatly enhanced to a similar degree if the severity of reduction in activity within nonreversible defects is considered.


Input: The temporal component lacked a mandibular fossa as well as articular eminence.


Input: EUK-8 is a novel, synthetic, low-molecular-weight salen-manganese complex that exhibits both superoxide dismutase and catalase activities in vitro.

superoxide dismutase

catalase


Input: The protein ELT-1, encoded by a single-copy gene homologous to the GATA family of vertebrate transcription factors, is potentially capable of interacting with this element.

protein ELT-1

GATA family of vertebrate transcription factors


Input: However, in contrast with previous in vitro cell-free integration studies, alteration of the highly conserved CA dinucleotide resulted in a mutant which still retained 40% of wild-type integration activity.


Input: These results demonstrate that although PI2 and PI3 viruses belong to the same parainfluenza virus genus, these viruses show marked differences with respect to functional requirements for the cytoplasmic tail of the F glycoprotein.

F glycoprotein


Input: By site-specific mutagenesis, we also show that individual ICP27 C-terminal amino acid residues that are positionally conserved in ICP27 homologs in other herpesviruses (D-357, E-358, H-479, C-400, C-483, and C-488) are critical for trans-regulatory activity.

ICP27 C-terminal amino acid residues

ICP27 homologs


Input: Magnetic resonance imaging (MRI) has enabled us to see the spinal intramedullary pathology as differences in signal intensity.


Input: Patients with psychotropic drugs showed significantly higher PRL levels.

PRL


Input: The Laser Scanning Ophthalmoscope enables a fundus-based examination and therefore allows exact comparison between morphologic appearance and corresponding function.


Input: Malaria, anaemia, and HIV-1 transmission in central Africa.


Input: In addition, two-dimensional nuclear magnetic resonance studies with F17A, K13Q, F15Y and F27Y revealed that the mutants have the same overall structure as the wild-type CspB protein.

wild-type CspB protein


Input: Considerably high levels of IgE antibodies was also established while other pollens did not show such correspondence.

IgE antibodies


Input: This is particularly intriguing because SKUT-1B-20 cells lack the transcription factor Pit-1.


Input: Some strains of A. parasiticus produced all four aflatoxins B1 B2 G1 G2, while the other ones produced AF B1 + G1 only, with concentrations of aflatoxins from 0. 1 to 450 mg/kg.


Input: We have isolated a new, larger rat B-myc genomic clone.

rat B-myc genomic clone


Input: In addition to the nine and 51 terminal amino acid forms already known, we identified a third with 43 terminal amino acids predicted to encode a novel RET protein isoform.

RET protein isoform


Input: Both classes of MHBst proteins were found to form dimers; an which is involved in mediating the dimerization.

MHBst proteins


Input: She had been receiving MTX 7. 5 mg/week for 2. 5 months because of her vasculitis symptoms.


Input: Analysis of the sequence identified four open reading frames (ORFs) which are designated UL1, UL2, UL3, and UL3. 5 based on their homology with proteins of herpes simplex virus-1 (HSV-1), pseudorabies virus (PRV), equine herpesvirus-1, and varicella-zoster virus.

UL3. 5


Input: These HPV16 E6/E7 cDNAs were cloned under the SV40 enhancer/promoter and the MMTV LTR to examine the activities of ras-collaborative transformation and induction of cellular DNA synthesis, both of which depend on the E7 gene product.

SV40 enhancer/promoter

MMTV LTR

ras

E7 gene


Input: Correlation coefficients between the reference methods and NIT were > or = 0. 95 for water, fat, crude protein and connective-tissue-protein frei meat protein, and > or = 0. 86 for connective-tissue-protein.


Input: The translation products of both clones are highly homologous to APS1 (66 and 86% identity, respectively) over their entire lengths, including amino terminal sequences resembling transit peptides for plastid localization.


Input: The serum levels of IgE, and asIgE and IgG-4 against 14 common food allergens were determined.

IgE

asIgE


Input: Two experiments investigating the effects of short-term spaceflight on cancellous bone turnover were carried out: Physiological Systems Experiment-1 (PSE-1) (a 4-d orbital spaceflight) and PSE-2 (a 10-d flight).


Input: Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast two-hybrid system.

aryl hydrocarbon receptor nuclear translocator

aryl hydrocarbon receptor


Input: Histopathologic observations showed that both somatostatin and triamcinolone acetonide reduced the inflammatory signs in the joint structures, although triamcinolone acetonide appeared to be more effective.

somatostatin


Input: An approach to a biomathematical model of lymphocytopoiesis.


Input: The influenza virus NS1 protein is a unique posttranscriptional regulator that has two activities: inhibition of the nuclear export of poly A-containing mRNAs and inhibition of pre-mRNA splicing.


Input: These are two regions of known conserved synteny, providing further evidence that the human STEP is a true homolog of the murine STEP gene.

human STEP

murine STEP gene


Input: Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci.

striatum-enriched phosphatase (STEP) gene


Input: Carbonic anhydrase V (CA V) is expressed in mitochondrial matrix in liver and several other tissues.

Carbonic anhydrase V

CA V


Input: Vitamin D3 plus nicotine treatment produced parallel increases in cardiac mass and elastic modulus, with a significant correlation between the two.


Input: The latter domain appears to be involved in targeting Num1p to the mother cell cortex.


Input: This finding is consistent with the notion that the dsRNA binding domains may be composed of two separate functional subdomains.


Input: Preferential heterodimeric parallel coiled-coil formation by synthetic Max and c-Myc leucine zippers: a description of putative electrostatic interactions responsible for the specificity of heterodimerization.

synthetic Max

c-Myc leucine zippers


Input: Comparison to other coxI genes revealed a 966-bp group I intron, which, based on homology with the related yeast coxI intron aI4, potentially encodes a 279-amino-acid site-specific DNA endonuclease.

coxI genes

yeast coxI intron aI4

DNA endonuclease


Input: We studied the GR in DMS-79 cells derived from a human ACTH-secreting small cell lung cancer.

GR

ACTH


Input: This study analyzed whether the localization of an accessory pathway could be predicted by using the polarity of the QRS complex during sinus rhythm on the surface ECG, instead of the delta wave polarity as used in many reports.


Input: The promoter mutation is complemented in trans by E1A products of the heterologous helper adenovirus type 5 (Ad5).


Input: Thus, as expected, trans-splicing depends on the integrity of U2, U4, and U6 snRNAs.

U6 snRNAs


Input: Treatment of PCC4. aza1R cells with an RAR-selective agonist also repressed the expression of EC-1 mRNA while treatment with an RXR-selective agonist reduced EC-1 expression slightly.

RAR

EC-1 mRNA

RXR


Input: Shift-down experiments indicated that the 10 (4)-to 10 (5)-fold reduction in virus yield at the nonpermissive temperature was due to the disfunction of alpha TIF late in infection, presumably in virion maturation.

alpha TIF


Input: These results demonstrate that tip acts at an early stage of the T-cell signal transduction cascade by associating with Lck and downregulating Lck-mediated activation.

tip

Lck


Input: Human immunodeficiency virus type 1 Vpr is a virion-associated, regulatory protein that is required for efficient viral replication in monocytes/macrophages.

Human immunodeficiency virus type 1 Vpr


Input: Here we examine the potential for VP16 protein-protein interactions specific to virus-infected cells and show that VP16 copurifies in a highly enriched fraction with a single major polypeptide which we identify as the virus-encoded structural protein VP22.


Input: Thus, transcriptional regulation, splicing, kinase interaction sites, and tyrosine phosphorylation of the LMP2A homologs have been conserved despite significant sequences heterogeneity in the preterminal repeat regions of these human and nonhuman primate EBVs.

LMP2A homologs


Input: Results of the ECAT Angina Pectoris Study Group.


Input: Therefore, a prospective Phase II trial was conducted to determine the safety and efficacy of cryosurgery following radiation therapy in men with local recurrence.


Input: These motifs include a Chi motif and a Chi-like element previously found in the recombination hotspot region of the Bcl-2 proto-oncogene and close to chromosomal breakpoints in T-ALL lines.

Bcl-2 proto-oncogene


Input: Common history and prospects in surgical gynecology of the Charite and the Vienna University Clinic


Input: In contrast with the previously reported HMGR1 mRNA (HMGR1S mRNA), which is detected at high levels in all tissues of the plant, HMGR1L mRNA is present at relatively low levels and its expression is restricted mostly to seedlings, roots and inflorescences.

HMGR1 mRNA

HMGR1S mRNA

HMGR1L mRNA


Input: However, the requirement of rev3 for the production of G. C--> T. A transversions by the rad18 mutator, which induces only these substitutions, was similar to that for rad6-mediated G. C--> T. A transversion.

rad18 mutator


Input: The second mutation present in the original mutant proved to be an allele of a known gene, PBS2, which encodes a putative protein kinase that functions in the high osmolarity stress pathway.


Input: In adult tissues, it was less restricted, indicating that RAFTK expression is developmentally up-regulated.

RAFTK


Input: As hGM-CSF receptor (hGMR) does not contain a consensus sequence for binding of PI 3-kinase, hGMR must use a distinct mechanism for its association with and activation of PI 3-kinase.

hGM-CSF receptor

hGMR

PI 3-kinase

hGMR

PI 3-kinase


Input: J.


Input: The identity between hnRNPs H and H' is 96%, between H and F 78%, and between H' and F 75%, respectively.

hnRNPs H

H'

H

F

H'

F


Input: In the present study, we transiently expressed in primary cultures of rat hepatocytes plasmids consisting of CYP3A1 5'-flanking sequences fused to a chloramphenicol acetyltransferase reporter plasmid.

CYP3A1 5'-flanking sequences

chloramphenicol acetyltransferase reporter


Input: We show that stimulation of resting splenic B cells with CD40L-expressing Sf9 cells induces germ-line gamma 1 and epsilon transcripts independently of cytokines.


Input: At the time of the 13 latest BPVs, age ranged from three days to 13. 1 years (mean 5. 7 +/-SD 4. 8 years).


Input: A tobacco homologue (trolC) of the rolC gene of the Agrobacterium rhizogenes Ri-plasmid was cloned and sequenced from Nicotiana tabacum L. cv.

trolC

rolC gene of the Agrobacterium rhizogenes Ri-plasmid


Input: High ADR1 gene dosage increased the transcription of genes encoding peroxisomal proteins as compared to one copy of the ADR1 gene.

ADR1 gene

ADR1 gene


Input: Of the three known C/EBP family inhibitors, Ig/EBP, LIP and CHOP-10, only Ig/EBP is ubiquitously expressed.

C/EBP family

Ig/EBP

LIP

Ig/EBP


Input: The effects of a 1-or 24-hour pretreatment regimen with monophosphoryl lipid A (MLA, 35 micrograms/kg i. v.) on myocardial stunning produced by repetitive coronary occlusions were studied in barbital-anesthetized dogs.


Input: A platelet-derived growth factor receptor (PDGF-R) phosphopeptide containing Tyr-857 does not bind appreciably to the Src SH2 domain, suggesting it is not the PDGF-R binding site for Src as previously reported.

platelet-derived growth factor receptor

PDGF-R

Src SH2 domain

PDGF-R

Src


Input: We have also tested Src SH2 mutants for their binding properties and have interpreted our results in light of the recent crystal structure solution for the Src SH2 domain.

Src SH2

Src SH2


Input: These observations link actin plaque assembly to increased cell substrate adhesion.

actin


Input: The early lethality of the left-sided resectio was 0% and the postoperative survival--5-10 months.


Input: There are two immunogenic sites on the type A influenza A/Japan/57 (H2N2) hemagglutinin (HA) that can be recognized by class I major histocompatibility complex (MHC), H-2Kd-restricted cytolytic T lymphocytes (CTLs).

hemagglutinin

HA

class I major histocompatibility complex

MHC


Input: This enhancer activates both the K19 and TK basal promoters in HeLa cells.

TK basal promoters


Input: Interestingly, one IRF binding site was found within the IRF-2 promoter, and expression of the IRF-2 gene was affected by both transient and stable IRF-1 expression.

IRF binding site

IRF-2 promoter

IRF-2 gene


Input: Therefore, we studied ninety coagulopathic patients with the aim of determining the prevalence of hepatitis C virus (HCV) antibodies using the ELISA and RIBA methods.

hepatitis C virus (HCV) antibodies


Input: The highest decrease in mutagenic activity was observed when enzymatic bleaching was used together with chlorine.


Input: There was also a highly significant correlation between total selenium intake and liver selenium concentration (r = 0. 99, p < 0. 01) after 1 mo of treatment, but this time liver selenium did not change with time, and the correlation remained highly significant throughout the investigation.


Input: Antibodies affinity-purified using the bacterially expressed recombinant protein recognized the 56K autoantigen in a HeLa cell extract. cDNA sequencing revealed that the 56K cDNA shares a high degree of homology in both nucleotide (87%) and amino acid sequence (92. 5%) with bovine annexin XI, indicating that the 56K cDNA encodes the human homologue of annexin XI, a member of the Ca (2 +)-dependent phospholipid binding protein family.

56K autoantigen

56K cDNA

bovine annexin XI

56K cDNA

human homologue of annexin XI

Ca (2 +)-dependent phospholipid binding protein family


Input: The avidin-biotin complex peroxidase (ABC-P) method was used to detect Mycobacterium bovis, and the results were compared with those obtained by the Ziehl-Neelsen (ZN) technique.

avidin-biotin complex peroxidase

ABC-P


Input: Its role in these processes suggests that the function of c-Myb may be important early in the establishment of the hematopoietic lineage.

c-Myb


Input: The transforming gene of the avian sarcoma virus CT10 encodes a fusion protein (p47gag-crk or v-Crk) containing viral Gag sequences fused to cellular sequences consisting primarily of Src homology regions 2 and 3 (SH2 and SH3 sequences).

avian sarcoma virus CT10

crk

v-Crk

viral Gag sequences

Src homology regions 2 and 3

SH3 sequences


Input: This specific methylation pattern caused inactivation of the HSV tk gene, while methylation of the cytosine residues within the nucleotide sequence from + 811 to + 1309 had no effect on HSV tk gene activity.

HSV tk gene

HSV tk gene


Input: CONCLUSION: This study documents that regression of choroidal neovascularization that occurred with alpha interferon treatment was minimal.

alpha interferon


Input: Long-range mapping of the 11q23 region involved in chromosome aberrations in human tumors by pulsed-field gel electrophoresis with a yeast artificial chromosome.


Input: GTRE, TRE, and CRE oligonucleotides all compete more efficiently for protein binding to their labeled congeners than for protein binding to either of the other labeled oligonucleotides, suggesting that the GTRE, TRE, and CRE oligonucleotides, suggesting that the GTRE, TRE, and CRE oligonucleotides each bind unique as well as common proteins, likely to be members of the Jun/Fos and cAMP-responsive element-binding protein/activating transcription factors (CREB/ATF) families of transcription factors, in chromaffin cells.

Jun

Fos

cAMP-responsive element-binding protein

activating transcription factors

CREB

ATF


Input: One patient only had any test abnormalities.


Input: One antibody, mAb1C2, and a synthetic peptide comprising its epitope selectively inhibited in vitro transcription from TATA-containing, but not from TATA-less promoters, irrespective of whether they were transcribed by Pol II or Pol III.

Pol II

Pol III


Input: The lymph nodes from two of the patients with rheumatoid arthritis contained numerous sarcoid like granulomata, further indicating a possible association between sarcoidosis and rheumatoid arthritis.


Input: HCV infection acquired during or after BMT caused only mild acute hepatitis C, which progressed to chronic hepatitis C in one patient surviving 10 years after BMT.


Input: Hepatitis C virus infection is a risk factor for liver failure from veno-occlusive disease after bone marrow transplantation.


Input: High plasma concentrations of soluble E-selectin were closely associated with multiple-organ dysfunction and death.

E-selectin


Input: These human IFN-beta-transformed cell populations have acquired a low, constitutive production of human IFN, while replicating at a rate similar to that of untransformed cells and of cells transformed with the control vector carrying a human IFN-beta sequence encoding an inactive, mutated protein.

IFN-beta

human IFN

human IFN-beta sequence


Input: Improvement of the polypyrimidine tract also increased the splicing efficiency, but to a degree slightly less than that obtained with the branchpoint mutation.


Input: Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.

SH2-containing protein tyrosine phosphatase

insulin receptor substrate-1


Input: In contrast, injection of a plasmid encoding simian virus 40 small t antigen, which interacts with PP2A to inhibit its activity towards several phosphoprotein substrates, had no effect on the phosphorylation state of CREB in stimulated or unstimulated NIH 3T3 cells.

simian virus 40 small t antigen

CREB


Input: Several Src SH3-binding proteins were phosphorylated in Src-transformed cells.

Src SH3-binding proteins

Src


Input: We also examined the effect of proteolytic processing in the MVE nonstructural polyprotein segment mediated by the viral proteinase NS3 on antigen processing and presentation of the MVE H-2Kk-restricted T cell determinant.

viral proteinase NS3


Input: A full-length PRL receptor (PRLR) complementary DNA from pigeons was obtained by screening pigeon crop sac libraries and by reverse transcription coupled with polymerase chain reaction.

full-length PRL receptor

PRLR


Input: After 7 days, a spontaneous regression of the morphologic alterations caused by caerulein-induced acute pancreatitis occurs; however, recovery of the secretory function of the pancreas was only reached after this period of time when L-364, 718 was administered therapeutically (0. 1 mg/kg/day).


Input: We observed that dephosphorylation severely inhibits the DNA-binding ability of C/EBP-delta and its transactivating potential increases in the presence of cellular phosphatase inhibitors, such as okadaic acid and sodium orthovanadate.

C/EBP-delta


Input: Two promoters were identified by S1 nuclease mapping: P1, which lies about 72 bp upstream from the structural gene; and P2, which lies about 35 bp upstream.

S1 nuclease


Input: On the other hand, cells containing a PTP1C in which the catalytic site had been inactivated through mutagenesis, stably phosphorylated the phosphatase.


Input: We recently found that the p72syk protein tyrosine kinase is physically associated with the TCR/CD3 complex and is rapidly tyrosine phosphorylated and activated by receptor triggering also in T cells lacking p56lck.

p72syk protein tyrosine kinase

TCR


Input: The transforming protein of Rous sarcoma virus, pp60v-src, and its normal cellular homolog, pp60c-src, differ not only in oncogenic potential but also in their subcellular localization and cytoskeletal binding ability. pp60v-src has been shown to stably associate with a detergent-insoluble cytoskeletal matrix, whereas pp60c-src does not.


Input: Organization of the bovine gene encoding the endothelial nitric oxide synthase.

endothelial nitric oxide synthase


Input: We determined whether regional myocardial work efficiency (segment work/regional O2 consumption) would be elevated by surgically-augmented inflow.


Input: In female Sl (pan)/Sl (pan) mice, ovarian follicle development is arrested at the one layered cuboidal stage as a result of reduced KL expression in follicle cells, indicating a role for c-kit in oocyte growth.

Sl (pan)/Sl (pan)

KL

c-kit


Input: Anti-NPROSP-C also exclusively detected time-dependent appearances of 5-10-kDa proSP-C forms in lamellar bodies and homogenates.

Anti-NPROSP-C

5-10-kDa proSP-C


Input: In the B6-derived Db mutant B6. CH-2bm13 (bm13) strain, part of the class I Db antigen-presenting groove is shaped by a class I Kb-encoded sequence.

Db mutant B6. CH-2bm13 (bm13)

class I Db antigen-presenting groove

class I Kb-encoded sequence


Input: Our findings confirm the high frequency of proximal nerve lesions in early GBS and CIDP, not all of which are associated with distal motor conduction abnormalities, and suggest that assessment of multiple F wave parameters, in particular chronodispersion, mean latency and mean amplitude (in addition to absence and minimum latency), increases the yield of F wave studies.


Input: Effects of alterations of primer-binding site sequences on human immunodeficiency virus type 1 replication.


Input: Presentation of a horse cytochrome c peptide by multiple H-2b class I major histocompatibility complex (MHC) molecules to C57BL/6-and bm1-derived cytotoxic T lymphocytes: presence of a single MHC anchor residue may confer efficient peptide-specific CTL recognition.

horse cytochrome c peptide

H-2b class I major histocompatibility complex

MHC

MHC anchor residue


Input: Diagnosis of prostatic carcinoma: the yield of serum prostate specific antigen, digital rectal examination and transrectal ultrasonography.

serum prostate specific antigen


Input: Increased granulocyte-colony stimulating factor (G-CSF) levels in neonates with perinatal complications.

granulocyte-colony stimulating factor

G-CSF


Input: The results revealed a hierarchy of ligand affinities that mirrored their adhesive activity (rsVCAM-1 > fibronectin variants containing CS1 > > other fibronectin variants).

fibronectin variants

fibronectin variants


Input: When expressed in and purified from Escherichia coli, both full-length Fpr3 and its isolated COOH-terminal domain exhibit readily detectable PPIase activity.

full-length Fpr3

PPIase


Input: However, expression of sigma 3 from S4 (3' UTR/S1), which included the PKR activator sequence from S1 within the 3'-UTR of S4, was comparable to that from wild-type S4.

sigma 3

3' UTR/S1

PKR activator sequence

3'-UTR of S4

wild-type S4


Input: Microvessels were counted in a x200 field (0. 754 mm2) in the area of maximal angiogenesis.


Input: Recent studies have demonstrated that the activated GH receptor can stimulate Stat1, a cytoplasmic transcription factor that becomes tyrosine phosphorylated and translocates to the nucleus, where it can interact with specific DNA sequences to modulate gene expression.

GH receptor


Input: In viral infections, G-CSF was correlated with mononuclear cells (rs = 0. 41, P < 0. 05), white blood cell counts (rs = 0. 56, P < 0. 01), neutrophils (rs = 0. 41, P < 0. 05) and CRP (rs = 0. 47, P < 0. 05).

G-CSF

CRP


Input: Minor initiation sites were found at positions-128,-111,-91, and-74.


Input: Phosphoamino acid analysis of radiolabeled ASGPR subunits identified Ser (P) as the predominant (approximately 95%) and Thr (P) as a minor (approximately 5%) phosphoamino acid in each polypeptide and confirmed the presence of Tyr (P) (approximately 1%) in RHL1.

ASGPR subunits


Input: To further define the structural requirements for ZAP-70 interaction with the TCR, we developed a binding assay using immobilized glutathione S-transferase fusion proteins containing the NH2-and/or COOH-terminal SH2 domains of ZAP-70, and soluble synthetic peptides with the sequence of the cytoplasmic region of the TCR zeta chain (TCR zeta cyt) or individual TCR zeta and CD3 epsilon TAM motifs.

TCR

glutathione S-transferase fusion proteins

COOH-terminal SH2 domains

TCR zeta chain

TCR zeta cyt

TCR zeta

CD3 epsilon TAM motifs


Input: All four doubly tyrosine phosphorylated TAM peptides cross-compete with each other for binding to the tandem SH2 domains of ZAP-70.

SH2 domains


Input: The three-dimensional structure of RT shows that it is a strikingly asymmetric heterodimer consisting of two differently folded subunits (molecular weights 66 kDa and 51 kDa) with identical amino-terminal amino acid sequences (residues 1-428).

RT


Input: Pharmacological and pharmacokinetic characteristics of the non-ionic monomeric X-ray contrast agent iopromide (Ultravist, CAS 73334-07-3) were evaluated in preclinical studies.


Input: All subsequent patients were treated at the maximal tolerated dose of EDXR (35 mg/m2/day).


Input: Addition of soluble recombinant human SLF to SI4-h220 cultures enhanced reduction of cell-surface c-kit expression and its protein degradation.

recombinant human SLF

c-kit


Input: Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form.

Steel factor

tyrosine kinase

c-kit


Input: Analysis of the sequences with the BLAST and GRAIL programs provided additional independent evidence that 15 of these 17 clones contain coding sequences and that nine other clones are likely to contain sequences coding for portions of new genes.


Input: Patients with more than 250 PVC/24 hours were selected for distribution of PVC and CI evaluation.


Input: Horvath, I.


Input: Cell lines derived from the tumors were examined by fluorescent in situ hybridization for the status of the transferred human chromosome and by PCR for marker loss.


Input: However, multiple alanine substitutions or proline (helix-destabilizing) substitutions disrupted both oligomerization and transport of GP64 EFP.

GP64 EFP


Input: The FinO protein of IncF plasmids binds FinP antisense RNA and its target, traJ mRNA, and promotes duplex formation.

FinO protein

FinP antisense RNA

traJ mRNA


Input: We linked a 4. 1-kilobase pair HindIII DNA fragment from the region upstream of the human AP endonuclease gene (APE) to the chloramphenicol acetyltransferase (CAT) gene.

HindIII DNA fragment

human AP endonuclease gene

APE

chloramphenicol acetyltransferase

CAT


Input: The overexpressed His6-tagged GrsA derivatives were affinity-purified, and the catalytic properties of the deletion mutants were examined by biochemical studies including ATP-dependent amino acid activation, carboxyl thioester formation, and the ability to racemize the covalently bound phenylalanine from L-to the D-isomer.

His6-tagged GrsA derivatives


Input: CD7 +/CD3-T-cell precursors exhibit V delta 2D delta 3 rearrangements.

V delta 2D delta 3 rearrangements


Input: HVH2 mRNA showed an expression pattern distinct from CL100 (human homologue of mouse MKP1) and PAC1, two previously identified MAP kinase phosphatases.

HVH2 mRNA

human homologue of mouse MKP1

MAP kinase phosphatases


Input: These data suggest that these sequences located immediately 3' to the breakpoint of the HPFH-3 deletion, exhibit both the structure and the function of an enhancer, and can modify the developmental specificity of the fetal gamma-globin genes, resulting in their continued expression during adult life.

HPFH-3 deletion

fetal gamma-globin genes


Input: Our results indicate that interaction between Jak2 and PRLR requires a proline-rich sequence in the membrane proximal region of the receptor, which is conserved among the different members of the cytokine receptor superfamily.

PRLR

cytokine receptor superfamily


Input: Transcription of the vascular cell adhesion molecule 1 (VCAM-1) gene in endothelial cells is induced by lipopolysaccharide and the inflammatory cytokines interleukin-1 beta and tumor necrosis factor alpha (TNF-alpha).

vascular cell adhesion molecule 1

cytokines interleukin-1 beta

tumor necrosis factor alpha

TNF-alpha


Input: Experiments with recombinant proteins showed that p50/p65 and high-mobility-group I (Y) protein cooperatively facilitated the binding of IRF-1 to the VCAM1 IRF binding site and that IRF-1 physically interacted with p50 and with high-mobility-group I (Y) protein.

high-mobility-group I (Y) protein

VCAM1 IRF binding site

high-mobility-group I (Y) protein


Input: Based on these results the minimal control element (AX 470) specifying the anterior boundary of Hox expression was designated as Hoxa-7 enhancer.

Hox

Hoxa-7 enhancer


Input: In this report we describe the isolation of a Fab fragment (Fab A8) showing a high relative affinity for the receptor (0. 5 nM).

Fab fragment

Fab A8


Input: MBP-Rep68 delta-mediated DNA-RNA helicase activity required ATP hydrolysis and the presence of Mg2 + ions and was inhibited by high ionic strength.

MBP

Rep68 delta


Input: To identify critical regions mediating growth signal transduction by hG-CSFR, deletions or site-directed amino acid substitutions were introduced into the cytoplasmic domain of hG-CSFR, and the mutant cDNAs were transfected into the murine interleukin-3 (IL-3)-dependent Ba/F3 and FDCP cell lines.

hG-CSFR

hG-CSFR

murine interleukin-3


Input: When combined with independent activating mutations in the c-abl kinase domain or NH2-terminus, the G128R mutation blocked transformation by the double mutant, suggesting that the G128R mutant was unable to transform cells for trivial reasons.

c-abl kinase domain

G128R mutant


Input: Both mutations completely abolished binding of the Abl SH3 domain to proline-rich target proteins in a filter-binding assay.

Abl SH3


Input: Changes induced in the gills of milkfish (Chanos chanos Forsskal) fingerlings after acute exposure to nifurpirinol (Furanace; P-7138).


Input: Retreatment of these 2 dogs resulted in a similar, but blunted, response to human immunoglobulin.

human immunoglobulin


Input: The levels of NSE and MBP in the IJVB were compared to those in the PVB.

NSE

MBP


Input: Morphologic variables included cancer volume, histologic grade, capsular penetration, seminal vesicle invasion, and lymph node metastasis.


Input: Sequence analysis of these regions showed a CAAT box upstream of exon 1a and high G-C content regions within both P1 and P2.


Input: The fusion proteins were tested by ELISA for reactivity with a panel of human anti-La sera in order to define the nature of the epitopes.

human anti-La sera


Input: GCD10 was first identified genetically as a translational repressor of GCN4.


Input: GCD10 binds RNA in vitro and we present strong biochemical evidence that it is identical to the RNA-binding subunit of yeast initiation factor-3 (eIF-3). eIF-3 is a multisubunit complex that stimulates translation initiation in vitro at several different steps.

yeast initiation factor-3


Input: Sources of noise in these signals were evaluated in preparations stained with the potentiometric probe RH-414.


Input: A transformation-competent mutant, like the wild-type E5 protein, bound the receptor and induced receptor tyrosine phosphorylation and down-regulation.

wild-type E5 protein


Input: We conclude that cAMP, acting through PKA, is an essential regulator of basal CFTR gene expression and may mediate an induction of CFTR in responsive cell types.

PKA

CFTR gene

CFTR


Input: Both PPC-1 and ALVA-31 cells display tumorigenesis and invasiveness in nude mice, whereas LNCap cells exhibit a less malignant phenotype, suggesting a correlation between CD44 variant (CD44v) expression and aggressive prostate tumor behavior.

CD44 variant


Input: Two such genes, designated hsiggll150 and hsiggll295, were cloned and sequenced from genomic DNA.


Input: A retrospective epidemiological study is reported concerning burn injuries in 775 children hospitalized at the unit of burn care of Casablanca between 1985 and 1993.


Input: Our results suggest that protein binding to the E2F-like sequences may act to reduce expression.

E2F-like sequences


Input: The RAD6/UBC2 gene from Saccharomyces cerevisiae encodes a ubiquitin-conjugating enzyme involved in DNA repair, induced mutagenesis, and sporulation.

ubiquitin-conjugating enzyme


Input: Echocardiography revealed right ventricular diastolic collapse (RVDC) without physical signs of cardiac tamponade.


Input: In on-going screening programmes, the Haemoccult test consists of six slides and a test is considered positive if at least one slide is coloured.


Input: We showed previously that a fusion protein (GAL4-p40) containing the DNA-binding domain of GAL4 and sequences of chicken l kappa B-alpha (p40) inhibits growth in the yeast Saccharomyces cerevisiae.

chicken l kappa B-alpha


Input: We have demonstrated previously that two binding sites in the-184 HNF-3 beta promoter are recognized by widely distributed factors and that there is also a critical autoregulatory site, we identified a binding site for a cell-specific factor, LF-H3 beta, that may function in restricting HNF-3 beta gene expression to hepatocytes.

-184 HNF-3 beta promoter

LF-H3 beta

HNF-3 beta gene


Input: In 4 spinalized cats, the effects of afferent inputs from hindlimb cutaneous nerves (sural cutaneous nerve: Sur) on mono-and poly-synaptic reflex recorded from tail muscle motoneurons were studied before and after spinal lesioning at S2-3 level.


Input: The flow rate of phosphate buffered saline through dermis was measured as a function of applied pressure.


Input: However, parallax measurements showed that at 150K, collapse of Epon sections does not take place.


Input: Although within normal limits, latency was high.


Input: The outcome of the optimization of the seven-field plan prompted an investigation into the best results that could be achieved by an " ideal " conformal radiotherapy technique.


Input: Specific requirements for branched-chain amino acids, glutamine, and arginine are evaluated.


Input: The pea rps10 intron is homologous to introns in rrn26 and cox3 in the Marchantia mitochondrial genome, while the Marchantia rps10 gene lacks an intron.

pea rps10 intron

Marchantia rps10 gene


Input: Serum magnesium in 79 patients of gynecologic neoplasms treated with cisplatin and their controls was measured.


Input: Alanine aminotransferase (ALT) levels had been elevated for six months in all patients and hepatitis B viral infection was replicative.

Alanine aminotransferase

ALT


Input: In this study we have investigated the role of C/EBP beta in initiating the adipogenic program by overexpressing C/EBP beta in multipotential NIH-3T3 fibroblasts.

C/EBP beta

C/EBP beta


Input: XYL1 was isolated as a highly expressed fusion clone from a' lacZ translational fusion library.

' lacZ


Input: Various transcripts are generated from the VCSA1 gene by alternative splicing and poly (A) processing in the rat submandibular gland.

VCSA1 gene


Input: However, division of the chest wall muscles, usually with diathermy, contributes to prolonged pain and morbidity.


Input: Closure of an open high below-knee guillotine amputation wound using a skin-stretching device.


Input: Our study was addressed to the synthesis of some derivatives of this sequence in order to obtain both peptide substrates suitable for the detection of the Src-like tyrosine kinase activity and active site-directed inhibitors specific for this class of enzymes.

Src

tyrosine kinase


Input: Citrate synthase activity was increased in the medial head (81%, P < 0. 001) and the red long head (88%, P < 0. 001) of the triceps brachii muscle in R rats but not in the white long head (25%, P = 0. 06).

Citrate synthase


Input: The expression of the putative operon bglPH of Bacillus subtilis was studied by using bglP'-lacZ transcriptional fusions.

bglPH

bglP'

lacZ


Input: Although eight contiguous genes necessary for urease activity have been cloned and sequenced, the transcriptional organization and regulation of specific genes within the Proteus gene cluster has not been investigated in detail.

urease

Proteus gene cluster


Input: The hypBFCDE operon from Rhizobium leguminosarum biovar viciae is expressed from an Fnr-type promoter that escapes mutagenesis of the fnrN gene.

hypBFCDE operon

Fnr-type promoter

fnrN gene


Input: We demonstrate that a VT + peptide was specifically phosphorylated by protein kinase C (PKC) in vitro, but not by protein kinase A (PKA).

protein kinase C

PKC

protein kinase A

PKA


Input: R.


Input: 15, 2500-2508; O' Neill, T.


Input: Control experiments showed that each fusion protein had a high affinity binding site for estradiol-17 beta and could transactivate an ERE-LacZ reporter gene in yeast similar to the wild type ER.

LacZ

wild type ER


Input: Although Micrococcus luteus UV endonuclease has been reported to be an 18-kDa enzyme with possible homology to the 16-kDa endonuclease V from bacteriophage T4 (Gordon, L.

Micrococcus luteus UV endonuclease

16-kDa endonuclease V from bacteriophage T4


Input: Several different oncogenes and growth factors promote G1 phase progression.


Input: Cyclin D1 promoter activity was stimulated by overexpression of mitogen-activated protein kinase (p41MAPK) or c-Ets-2 through the proximal 22 base pairs.

Cyclin D1 promoter

mitogen-activated protein kinase


Input: Indeed, ERM and c-Jun synergistically activated the EBS-CRE without making an apparent ternary complex.

ERM

c-Jun


Input: In addition, the R206S HSF substitution exhibits constitutive transcriptional activation from a consensus HSE (HSE2).

R206S HSF


Input: After recovery, a hypertonic saline challenge was performed.


Input: The range of eosinophils was 22-56% of the number of peripheral white blood cells (mean nadir 33%).


Input: Comparisons of rrnB P1-lacZ expression at different ppGpp levels is interpreted for the rpoD (P504L) mutant as resulting from a hypersensitivity to ppGpp.

rrnB P1

lacZ

rpoD (P504L) mutant


Input: These intron chimeras show that peripheral sequences and the elements that define the splice sites are adequate for self-splicing activity but that the central portions containing the catalytic cores of ai4 and bi4 are deficient; these cores are the likely targets of the splicing proteins.


Input: Here we demonstrate genetically that plus-strand DNA synthesis of the yeast Ty1 element is initiated at two sites located at the 5' boundary of the 3' long terminal repeat (PPT1) and near the middle of the pol gene in the integrase coding sequence (PPT2).

yeast Ty1 element

pol gene

integrase coding sequence


Input: Characterization of the 3' ends of the plus-strand DNA fragments reveals (1) that the upstream fragment is elongated beyond PPT2 creating a plus-strand overlap and (2) that the majority of plus-strand strong-stop DNA fragments bear a copy of the minus-strand primer binding site in agreement with the accepted model of retroviral genomic RNA reverse transcription.


Input: The patients undergoing VTLB had significantly shorter operative times (VTLB, 100. 2 +/-27. 2 min. vs OLB, 119. 8 +/-42. 6 min; p < 0. 01) and less blood loss (VTLB, 4. 7 +/-14. 6 ml vs OLB, 65. 7 +/-77. 0 ml; p < 0. 001).


Input: By 150 minutes after Cr2O3 inhalation, FEV1. 0 had decreased by 32%.


Input: This combined intravenous anaesthetic regimen gave good anaesthesia and analgesia to pigs for up to 2 h as monitored by clinical signs.


Input: Twenty food products were contaminated with V. cholerae O1, Ogawa, toxigenic and not toxigenic strains: yoghurt, cream cheese, apricot marmelade, hip rose marmelade, mayonnaise, italian pasta for " empanadas ", " dulce de leche ", meat sausage, meat and spinach ravioli, margarine, milk dessert (made with cocoa, milk confiture, starch and additives), lettuce, tuna fish, ricotta and sterilized milk.


Input: It is impossible to define only one clinical outline because both symptomatic and asymptomatic infected NB may be found with gestational age at term and pre-term and when born with a weight above or below 2000 g.


Input: The expression of the pilin gene, tcpA, is dependent upon ToxR and upon ToxT.

pilin gene

tcpA

ToxR

ToxT


Input: Ras p21Val inhibits myogenesis without altering the DNA binding or transcriptional activities of the myogenic basic helix-loop-helix factors.

Ras p21Val

myogenic basic helix-loop-helix factors


Input: In cells limited for His, increased expression of arg-2 and cpc-1, and decreased expression of cox-5, also had translational and transcriptional components.


Input: The peptide sequences reveal that the factor consists of GABP alpha and GABP beta 1 with Ets and Notch motifs, respectively.

GABP alpha

GABP beta 1

Ets

Notch motifs


Input: Immunofluorescence microscopy and cell fractionation analyses showed that the 110-kDa protein was exclusively nuclear, whereas the 150-kDa protein was present in both the cytoplasm and nucleus of human cells.


Input: Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase.

interferon

double-stranded-RNA-specific adenosine deaminase


Input: T-cell hybridomas, thymocytes, and T cells can be induced to undergo apoptotic cell death by activation through the T-cell receptor.

T-cell receptor


Input: Deletions were examined in the LYS2 gene, using a set of 31-to 156-bp inserts that included inserts with no apparent potential for secondary structure as well as two quasipalindromes.

LYS2 gene


Input: Overexpression of SCS1 could not complement an HSP60-null allele, indicating that suppression was not due to the bypassing of Hsp60 activity.

HSP60-null allele


Input: The DNA binding domain of NirA was expressed as a fusion protein with the glutathione S-transferase of Schistosoma japonicum.

NirA

glutathione S-transferase


Input: The kinase is essential in vivo for normal phosphorylation of the CTD and for normal growth and differentiation.


Input: Finally, we demonstrate that C/EBP alpha can also active the GM-CSF receptor alpha promoter in nonmyeloid cells.

C/EBP alpha

GM-CSF receptor alpha


Input: Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae.

Pdr5 ATP-binding cassette multidrug transporter


Input: Disruption of the HOG1 and PBS2 genes leads to a dramatic decrease of the HSP12 inducibility in osmostressed cells, whereas overproduction of Hog1 produces a fivefold increase in wild-type induced levels upon a shift to a high salt concentration.

PBS2 genes


Input: Deletion or inactivation of CRY1 leads to 5-to 10-fold-increased levels of CRY2 mRNA.

CRY2 mRNA


Input: (1986) method of separation of Cryptosporidium spp. oocysts from feces by using a percoll discontinuous density gradient appeared a method of choice for obtaining large numbers of oocysts of C. parvum free of fecal contamination.


Input: METHODS: We obtained maximal inspiratory and expiratory flow-volume curves in 41 unselected patients with essential tremor (14 males, 27 females, age 61. 7 +/-2. 14 years).


Input: Our findings also provide the basis for the development of assays to screen for the ligands to testis receptor 2 and hERR1.

testis receptor 2


Input: Four p53 DNA-binding domain peptides bind natural p53-response elements and bend the DNA.

p53 DNA-binding domain peptides

p53-response elements


Input: The Stat5b mRNA has a size of 5. 6 kb and encodes a protein of 786 amino acids.

Stat5b mRNA


Input: The hydropathy plot revealed a rather hydrophilic N-terminal region and the absence of a hydrophobic signal peptide.


Input: This report focused on the relationship between Type A behavior and eight basic emotion dimensions.


Input: All carcasses resulted in contamination with aerobic mesophilic bacteria in the range from 6 x 10 (3) to 1. 2 x 10 (6) CFU/ml liquid washed, and 94% them with sporulate bacteria, the threshold being under 100 CFU/ml (Figure 1).


Input: As for 31 stage I-II lung cancer patients, CR has been observed in 82. 8% of them and PR in 13. 8%; the response was always assessed with chest radiography, CT, FBS, cytology and/or histology.


Input: Pediatric medical emergencies in a regional hospital: appropriate locale?


Input: Protein electrophoresis showed decreased albumin levels in both groups, with lower values in G2.

albumin


Input: METHODS: All these 30 non-responders received an extra dose of the same vaccine 2 months after primary immunization and a booster dose with a yeast-derived vaccine 6 years later.


Input: An abnormally high percentage of hypertensive patients (approximately 30%) undergoing cardiac catheterization because of anginal pain and/or exercise-induced ST-segment depressions has angiographically normal coronary arteries.


Input: Mibefradil (Ro 40-5967) is a novel calcium antagonist from a new chemical class and is the first that selectively blocks the T-type calcium channel.


Input: However, 2 minimum alveolar concentration anesthesia did significantly decrease the calculated VE at a PCO2 of 60 mmHg (from 7. 4 +/-1. 2 to 4. 0 +/-0. 6 l. min-1), indicating a rightward shift in the response relationship.


Input: cDNA encoding a functional feline liver/bone/kidney-type alkaline phosphatase.

feline liver/bone/kidney-type alkaline phosphatase


Input: Protein kinase C (PKC), a widely-distributed enzyme implicated in the regulation of many physiological processes, consists of a family of at least twelve isoenzymes which differ in tissue distribution, subcellular localization, regulatory properties, etc.

Protein kinase C

PKC


Input: This work, therefore, also emphasizes the importance of careful choice of oligonucleotide and cDNA probes to study PKC zeta mRNA.

PKC zeta mRNA


Input: This action is dependent on helix-loop-helix factors bound to the E1 element.

helix-loop-helix factors


Input: The debate over electives--1899.


Input: Polypeptide growth factors and cytokines mediate their biochemical functions through their responsive receptors.


Input: However, a strongly increased frequency of CpG dinucleotides was found.


Input: During the dose-finding, two patients were temporarily withdrawn from medication and one patient was excluded because of elevated levels of liver enzymes.


Input: In comparison of cDNA and genomic sequences four RNA editing events were found in both atp9 genes.

atp9 genes


Input: MZF-1 represses CAT reporter gene expression via GAL4 binding sites in the nonhematopoietic cell lines NIH 3T3 and 293.

CAT reporter gene

GAL4 binding sites


Input: As with the heterologous DNA binding domain, MZF-1 represses reporter gene expression in nonhematopoietic cell lines and activates expression in hematopoietic cell lines.


Input: Analyses of hGMR beta subunit mutants revealed two cytoplasmic regions involved in activation of the c-myc promoter, one is essential and the other is dispensable but enhances the activity.

hGMR beta subunit mutants

c-myc promoter


Input: Similarly, we observed synthetic phenotypes between mutations in MIF2 and trans-acting mutations in three known yeast centromere protein genes-CEP1/CBF1/CPF1, NDC10/CBF2, and CEP3/CBF3B.


Input: Taken together, these data suggest that the Mif2 protein interacts with Cep1p at the centromere and that the yeast centromere indeed exists as a higher order protein-DNA complex.

Mif2 protein


Input: To accomplish this, actin cables and patches are redistributed during the cell cycle to direct secretory components to appropriate sites for cell growth.

actin


Input: The effects of Codonopsis pilosula oral liquor (CPOL) on tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) in the plasma of 25 patients of coronary heart disease with blood stasis were studied.

tissue-type plasminogen activator

t-PA

plasminogen activator inhibitor

PAI


Input: Estimated daily intakes (EDIs) per person were 0. 56 microgram for total HCH, 0. 20 microgram for gamma-HCH, 0. 09 microgram for dieldrin, 1. 42 micrograms for total DDT, and 0. 15 microgram for HCB.


Input: In two further cases (one type I and one type III SMA), de novo deletions of only one copy of Ag1-CA and C212 were found.


Input: With each of the three pairs of isolates (case and suspicious case), identical IS6110 banding patterns were found suggesting identical MTB strains.


Input: HRES has been found to be clinically useful in assessing histologic damage following pneumatic dilatation and in localizing the LES during the administration of intrasphincter botulinum toxin injection in the treatment of achalasia.

botulinum toxin


Input: These early structural processes are assumed to be subserved by the anterior parts of the left hemisphere, as event-related brain potentials show this area to be maximally activated when phrase structure violations are processed and as circumscribed lesions in this area lead to an impairment of the on-line structural assignment.


Input: In men with BMI < 30, the OR was 1. 83 for postprandial TG (P =. 041) and 2. 77 for postprandial RP (P =. 032) in models that included fasting TG, LDL-C, and hypertension.

LDL-C


Input: A pyrazolo-quinoline compound, 6-methoxy-4-[2-[(2-hydroxyethoxyl)-ethyl] amino]-3-methyl-1M-pyrazo lo [3, 4-b] quinoline (SCH 51344), was identified based on its ability to derepress human smooth muscle alpha-actin promoter activity in ras-transformed cells.

alpha-actin promoter

ras


Input: On the basis of these relations, a risk factor-selection scale (RFSS) (range, 0 to 10) was developed by computing appropriate weights for each risk factor.


Input: The Caenorhabditis elegans death susceptibility gene, ced-3, has a number of homologs in vertebrate species, including interleukin-1 beta (IL-1 beta)-converting enzyme (ICE), Ich-1long, and CPP32.

Caenorhabditis elegans death susceptibility gene

interleukin-1 beta (IL-1 beta)-converting enzyme

ICE


Input: Repression of glucocorticoid receptor-mediated transcriptional activation by unliganded thyroid hormone receptor (TR) is TR isoform-specific.

glucocorticoid receptor

thyroid hormone receptor

TR

TR


Input: The results indicate considerable flexibility in the spacing between DH regulatory sites.

DH


Input: Obstruction of the ERF repressor function by the transactivating members of the ets family of genes (i. e. gag-myb-ets) may be essential for the control of genes involved in cell proliferation and may also underlie their tumorigenic effects.

ERF repressor

ets family

gag

myb

ets


Input: We show that c-Fos (the c-fos protooncogene product), which is an intrinsically unstable nuclear protein, is metabolically highly stabilized, and greatly enhances the transforming efficiency of NIH 3T3 cells, by Mos.

c-Fos

c-fos protooncogene product

Mos


Input: Cloning, sequencing and expression of the 3-phosphoglycerate kinase gene of Pyrococcus woesei in Escherichia coli and characterization of the protein.

3-phosphoglycerate kinase gene


Input: We sought to determine whether such differences in polyadenylation affect the steady-state levels of DHFR and mRNAs expressed from either allele and, in a more general sense, to ask whether differences in 3' end RNA processing in a gene containing multiple poly (A) sites affects the final level of gene expression.

DHFR


Input: The finding that the chimeric TdT:: Pol beta protein possessed significant template-dependent polymerase activity suggests that aa 1-60 of Pol beta are involved in template utilization during the polymerization reaction, as suggested by the previous finding that the 8-kDa N-terminal domain of Pol beta possesses ssDNA-binding activity [Kumar et al., J.

chimeric TdT

Pol beta protein

Pol beta

Pol beta


Input: The average values were 199 and 424 revertants/g for the hamburgers and hot dogs, respectively.


Input: Cholangiography was performed in all cases and classified by a scoring system specifically developed for pediatric patients.


Input: In Trial 1, eight sows were allowed to farrow naturally (d 114, NF sows) and eight sows were induced to farrow (IF sows) prematurely by injection of prostaglandin F2 alpha on d 112 of gestation.


Input: End-tidal PO2 and the ratio of minute ventilation to oxygen consumption (VE/VO2) were lower while PETCO2 was higher for Hyp (P < or = 0. 01).


Input: These results suggested that NfxB negatively autoregulates the expression of nfxB itself.

NfxB

nfxB


Input: A511 is a broad-host-range, virulent myovirus for Listeria monocytogenes.


Input: The mechanism of peroxisome proliferation is poorly understood.


Input: If NCR-sensitive gene expression occurs exclusively by this pathway, as has been thought to be the case, then the NCR sensitivity of a gene' s expression should be abolished by a ure2 delta mutation.

ure2 delta mutation


Input: The single-stranded DNA Pur alpha recognition element disrupts these complexes.

Pur alpha recognition element


Input: Association of human Pur alpha with the retinoblastoma protein, Rb, regulates binding to the single-stranded DNA Pur alpha recognition element.

human Pur alpha

retinoblastoma protein

Rb

Pur alpha recognition element


Input: The insulin-induced DNA-binding complex was identified as the p50/p65 heterodimer.

insulin


Input: Using varying conditions, three distinct complexes were shown to interact specifically with the NIP region, although only one correlates with repressor activity.

NIP region


Input: Exchange of the LPL and HL lids resulted in a reversal of the phospholipase/neutral lipase ratio, establishing the important role of this region in mediating substrate specificity.

LPL

HL

phospholipase

lipase


Input: The interferon-inducible protein kinase PKR modulates the transcriptional activation of immunoglobulin kappa gene.

interferon

protein kinase PKR

immunoglobulin kappa gene


Input: Truncated forms of a novel yeast protein suppress the lethality of a G protein alpha subunit deficiency by interacting with the beta subunit.

G protein alpha subunit


Input: Another common mutation involved amino acids that are thought to make specific contacts with DNA.


Input: Levels of TSG-14 protein (also termed PTX-3) become elevated in the serum of mice and humans after injection with bacterial lipopolysaccharide, but in contrast to conventional acute phase proteins, the bulk of TSG-14 synthesis in the intact organism occurs outside the liver.

TSG-14 protein


Input: The mouse beta 2-syntrophin gene (> 33 kilobases) contains seven exons, all of which have homologues at the corresponding position in the alpha 1-syntrophin gene.

mouse beta 2-syntrophin gene

alpha 1-syntrophin gene


Input: Altogether our data indicate that PEDF belongs to the subgroup of noninhibitory serpins and that its N-terminal region confers a neurite-promoting activity to the protein.

PEDF

serpins


Input: We report here the cloning of the murine p44 MAP kinase (extracellular signal-regulated kinase 1) gene, the determination of its intron/exon boundaries, and the characterization of its promoter.

p44 MAP kinase

extracellular signal-regulated kinase 1


Input: It contains three putative TATA boxes far upstream of the main start sites region, one AP-1 box, one AP-2 box, one Malt box, one GAGA box, one half serum-responsive element, and putative binding sites for Sp1 (five), GC-rich binding factor (five), CTF-NF1 (one), Myb (one), p53 (two), Ets-1 (one), NF-IL6 (two), MyoD (two), Zeste (one), and hepatocyte nuclear factor-5 (one).

AP-1 box

AP-2 box

Malt box

GC-rich binding factor

Myb

MyoD

Zeste

hepatocyte nuclear factor-5


Input: We conclude that this new measurement technique provides an easy and accurate P0. 1 measurement using standard respiratory equipment when tested in a lung model.


Input: Effects of verapamil and propranolol on early afterdepolarizations and ventricular arrhythmias induced by epinephrine in congenital long QT syndrome.


Input: Deletion of the NF-IL6 beta leucine zipper domain also greatly diminished the interaction between these two proteins.

NF-IL6 beta leucine zipper domain


Input: After cells were stably transfected with CIITA, endogenous MHC class II genes were constitutively expressed, and MHC class II promoters, delivered by transfection, were actively transcribed in CIITA-expressing cells.

CIITA

MHC class II genes

MHC class II promoters

CIITA


Input: Two domains of EBNA2 defined by deletion of amino acids 247-337 and 437-476 were found to be important for the activation of both promoters, while two different domains corresponding to residues 4-18 and 118-198 were required solely for the LMP1 promoter.

LMP1 promoter


Input: The peak velocities of the atrial systolic waves of the transmitral and pulmonary venous flow velocities (A and PVA, respectively) and first systolic wave (PVS1) of pulmonary venous flow, durations of both atrial systolic waves, and amplitude of interatrial septal motion during atrial systole increased significantly ten days after cardioversion compared with those measured within a day of cardioversion in all patients except the 5 patients with dilated cardiomyopathy.


Input: These results suggest that low concentrations of IL-1 beta may be useful for nonsurgical treatment of human vitreous hemorrhage.

IL-1 beta


Input: We conclude that pancreatic polypeptide and motilin responses to a meal are different in encopretic children than in children in the control group.

motilin


Input: Here we report the cloning, expression, and biochemical characterization of the 32-kDa subunit of human (h) TFIID, termed hTAFII32.

TFIID


Input: Hemolytic jaundice due to G6PD deficiency causing kernicterus in a female newborn.


Input: Two transcripts of 1. 6 kb and 5. 8 kb are 5' coterminal and may both encode the novel glycoprotein gene EUS4.

glycoprotein gene EUS4


Input: However, the few studies that address antimicrobial prophylaxis in bone marrow transplantation have not always shown a survival benefit.


Input: The fracture groups were significantly older and had more years since menopause than the control groups.


Input: In addition, we found differences in the binding of nuclear factors from shoots versus from roots, in agreement with the different activities of the promoter in these two organs.


Input: The prevalence and incidence of human immunodeficiency virus types 1 and 2 (HIV-1, HIV-2), human T-lymphotropic virus types I and II (HTLV-I/II), and syphilitic infections and the association between these infections were determined in a cohort of police officers in Guinea-Bissau.


Input: We now show that the BAT1 translation product is the homolog of the rat p47 nuclear protein, the WM6 Drosophila gene product, and probably also Ce08102 of Caenorhabditis elegans, all members of the DEAD protein family of ATP-dependent RNA helicases.

BAT1 translation product

rat p47 nuclear protein

WM6 Drosophila gene product

DEAD protein family

ATP-dependent RNA helicases


Input: By using lacZ fusions, it was possible to localize the DNA sequences required to mediate nitrate repression to the pfl promoter-regulatory region.

lacZ fusions

pfl promoter-regulatory region


Input: In this report, we describe the characterization of two early class II flagellar genes contained in the orfX-fliP locus.

class II flagellar genes

fliP


Input: Vestibular adaptation exercises and recovery: acute stage after acoustic neuroma resection.


Input: There were no significant changes in either the fatty acid composition of biliary lecithin or in the bile acid composition of bile.


Input: Although further studies are required to determine the precise role of PEBP2 in the GM-CSF promoter activity, the present findings suggested the importance of the relative ratio of different PEBP2 isoforms in regulating the levels of the promoter activity.

GM-CSF promoter

PEBP2 isoforms


Input: Benefits of obtaining board certification in pharmacotherapy.


Input: Basal plasma renin activity (PRA) was slightly raised prior to training (P < 0. 07) compared to the controls and post-training.

renin


Input: The structural gene encoding the novel lantibiotic epilancin K7 from Staphylococcus epidermidis K7 was cloned and its nucleotide sequence was determined.

epilancin K7


Input: The spectrum of phenotypes caused by these mutations was strikingly different than mutations in the adaptor for the VP16 activation domain.

VP16 activation domain


Input: The 5' flanking region is highly GC rich, with multiple CpG doublets, and contains multiple binding sites for Sp1.


Input: To discern whether these disorders of GnRH deficiency are associated with altered melatonin secretion profiles, we compared untreated young males IGD (n = 7) and DP (n = 7) to normal pubertal male controls (n = 6).

GnRH


Input: Increased blood pressure during CyA treatment was independent of circulating ET-1 levels.


Input: Analysis of several Tat mutants indicated that both the cysteine-rich and the core domains of this transactivator are necessary and sufficient to activate transcription when TBP is overexpressed.

Tat mutants

TBP


Input: In addition, depletion of Oct-1 from the nuclear extract by using Oct-1-specific antiserum or a sequence-specific DNA affinity resin decreased in vitro transcription from the wild-type MMTV promoter to a level identical to that obtained from a promoter in which all three octamer-related sequences were mutated.


Input: Transactivation of the HIV-1 LTR by T3R alpha and several receptor mutants revealed that the 50-amino-acid N-terminal A/B region of T3R alpha, known to interact with the basal transcription factor TFIIB, is critical for activation of both Tat-dependent and Tat-independent responsive sequences of the LTR.

HIV-1 LTR

T3R alpha

T3R alpha

basal transcription factor TFIIB

Tat

Tat


Input: M. M. C. was used for 2. 5 minutes in 44 cases (20 HR patients, 24 LR patients), and for 5 minutes in 66 cases (46 HR patients, 20 LR patients).


Input: Finally, we show that complexes similar to the C25, C30 and C35 complexes are formed by rat cortex nuclear extracts and the SAA element in EMSA experiments, suggesting the relevance of our in vitro observations to the in vivo functioning of the rat APP promoter.

C35 complexes

rat APP promoter


Input: Oncological, clinical and psychological aspects are evaluated according to experience accumulated in recent years, with immediate and delayed reconstruction, carried out in the most diverse specialized centers.


Input: The analysis of the prevalence values shows clearly that the global MS-frequency is closer related to the geomagnetic than to the geographic latitude.


Input: Diltiazem caused significant decrease in the ventricular response without conversion to sinus rhythm.


Input: Subhuman primates appear to be more sensitive to reproductive and other adverse effects of PCBs than humans.


Input: When excluding children with ocular and cerebral pathology, 32 matched pairs of premature and control children remained.


Input: The cryptococcal antigen test was positive at 1: 125 by latex agglutination.

cryptococcal antigen


Input: Functional analysis of DNase-I hypersensitive sites at the mouse porphobilinogen deaminase gene locus.

DNase-I

mouse porphobilinogen deaminase gene locus


Input: These transcripts have a unique 5' untranslated region and NH2-terminal sequence and encode a predicted protein of 121 kD.


Input: Both mu and gamma 2b heavy chain genes cause this feedback inhibition of heavy chain gene rearrangement.

mu and gamma 2b heavy chain genes


Input: Purified CarP binds in vitro to the carAB control region and protects against DNase I two approximately 25 bp long stretches, one of which is located just downstream of the GATC sequence.

CarP

carAB control region

DNase I


Input: They include genes encoding three subunits of the cytochrome oxidase (cox1 to 3), apocytochrome b (cob), seven subunits of the NADH dehydrogenase complex (nad1 to 6, nad4L), two ATPase subunits (atp6 and atp9), three ribosomal RNAs (rrn5, srn and lrn), 23 tRNAs and four ribosomal proteins (rps3, rps11, rps12 and rpl16).

cytochrome oxidase

cox1 to 3

apocytochrome b

cob

NADH dehydrogenase complex

nad1 to 6

ATPase

srn

lrn


Input: From day 10, a significant increase in platelet count was observed in eight of the ten patients treated with heparin (p < 0. 05), with return to the initial value after heparin cessation in six of the responders.


Input: These " nucleocapsid-like " structures were readily purified by density gradient centrifugation.


Input: Resources for helping patients to quit smoking.


Input: The PEBP2 alpha proteins contain a 128-amino-acid (aa) region highly homologous to the Drosophila melanogaster segmentation gene runt.

PEBP2 alpha proteins

Drosophila melanogaster segmentation gene runt


Input: In human proliferative cells, the NADP-dependent ME activity is poorly expressed and barely inducible by thyroid hormones.

ME


Input: Based on previous mapping of the G beta gamma binding region of beta ARK, and conserved residues within the PH domain, we have constructed a series of mutants in the carboxyl terminus of beta ARK in order to determine important residues involved in G beta gamma and PIP2 binding.

G beta gamma binding region

beta ARK

PH domain

beta ARK

G beta gamma


Input: To dissect these mechanisms, wild-type and mutant Raf-1 proteins were studied in an in vitro system with purified plasma membranes from v-Ras-and v-Src-transformed cells (transformed membranes).

mutant Raf-1 proteins

v-Ras

v-Src


Input: In CV-1 cells, cotransfection of the retinoid and estrogen receptors led to mutual inhibition of the other' s activity, while an RA-dependent inhibition of ER activity was observed in breast cancer cells.

retinoid and estrogen receptors

ER


Input: D.


Input: It was proposed that the synthetase-related sequences of GCN2 stimulate the activity of the kinase by interacting directly with uncharged tRNA that accumulates during amino acid limitation.


Input: However, unlike Bcl-2 and the E1B 19K proteins, which completely block apoptosis but not p53-dependent growth arrest, H-ras expression permitted DNA synthesis and cell proliferation in the presence of high levels of wild-type p53.

E1B 19K proteins

H-ras

wild-type p53


Input: To compare the PAX3 and putative PAX3-FKHR transactivation domains, we fused C-terminal test fragments to the heterologous GAL4 DNA-binding domain and tested activation of a reporter gene co-transfected into four cell types.

FKHR

GAL4 DNA-binding domain


Input: All subjects were submitted to ECG and arterial blood pressure determination and were assayed for TSH, thyroid hormone, PRL, glucose, creatinine, nitrogen, glutamine transaminase, cholesterol and triglycerides plasma levels before therapy (T0), after 30 treatment days (T30) and after a 15 days washout (T45).

TSH

PRL

glutamine transaminase


Input: Acute decrease in body temperature (TB) lowered PaCO2 (32. 5 to 14. 5 mmHg) and [HCO3-] a (24. 20 mEq/L to 17. 56 mEq/L), increased pHa (7. 481 to 7. 608) and diminished the [OH-]/[H +] ratio, but had no significant effect on [SID] or [Atot], although both total phosphorus [PT] and inorganic phosphate [Pi] increased.


Input: Hepatitis B vaccine: still has its problems.


Input: Basal promoter activity is enhanced by a functional M1 domain in LHR-expressing mouse Leydig tumor cells (MLTC) but not in non-expressing CHO cells.

LHR


Input: For Al, the exposure to 1. 36 mg/m3 during the shift corresponded to a urinary concentration at the end of the shift of 200 microgram/g creatinine.


Input: Tumor necrosis factor-alpha (TNF alpha), a proinflammatory cytokine, inhibits cAMP-stimulated testosterone production in mouse Leydig cells.

Tumor necrosis factor-alpha

TNF alpha


Input: The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential.

Drosophila insulin receptor homolog


Input: We show here that RA and E1A induce phosphorylation of the E1A-associated 300 kDa protein (p300) during the differentiation of F9 cells.

E1A-associated 300 kDa protein


Input: The double-stranded RNA binding domain (dsRBD) is an approximately 65 amino acid motif that is found in a variety of proteins that interact with double-stranded (ds) RNA, such as Escherichia coli RNase III and the dsRNA-dependent kinase, PKR.

RNase III

dsRNA-dependent kinase

PKR


Input: SCA was resistant to inhibitors of serine, aspartyl, and metalloproteases, but it was sensitive to N-ethylmaleimide.

SCA

metalloproteases


Input: Mutational analysis of potential activating phosphorylation sites found in NIMA, NIM-1, and related protein kinases was performed on NIMA.

NIMA

NIMA


Input: However, a similar mutation of a leucine residue to arginine at position 422 showed no alteration of heterodimerization, DNA binding, or transcriptional activation.


Input: Expression of the CYP11A1 gene is increased by hormones, such as adrenocorticotropin and luteinizing hormone, as well as by a number of growth factors, suggesting that its promoter may contain regulatory elements that respond to multiple signal transduction pathways.

CYP11A1 gene

adrenocorticotropin

luteinizing hormone


Input: NH2-and COOH-terminal deletion analysis revealed that both the PH and putative guanine nucleotide exchange factor domains are required, but the zinc butterfly is dispensable, for transformation.

PH

guanine nucleotide exchange factor domains


Input: The objective of our study was to evaluate the age, sex, clinical conditions, family history, site, catheter association, means of radiologic evaluation, development of pulmonary involvement, prevalence of antithrombin III, protein C and protein S deficiencies, and lupus anticoagulants in children who suffered a thrombotic event.

antithrombin III

protein C

protein S


Input: Harel, E. M.


Input: Radiotherapy and early orchiectomy in stage D1 prostatic carcinoma


Input: Structural organization and developmental expression pattern of the mouse WD-repeat gene DMR-N9 immediately upstream of the myotonic dystrophy locus.

mouse WD-repeat gene DMR-N9

myotonic dystrophy locus


Input: The ARX2 procedure models the recorded signal as the sum of three signals: (a) the background EEG activity, modelled as an autoregressive process driven by a white noise; (b) a filtered version of a reference signal carrying the average information contained in each sweep; (c) a signal due to the ocular artefact propagation.


Input: The expression of the gene encoding the enzyme (CYP19) is regulated, in part, by tissue-specific promoters through the use of alternative-splicing mechanisms.


Input: CIITA mRNA is normally inducible by IFN-gamma in class II non-inducible, RB-defective lines, and in one line, re-expression of RB has no effect on CIITA mRNA induction levels.

CIITA mRNA

IFN-gamma

RB

CIITA mRNA


Input: Consistent with the protein expression data, V beta 8. 3 gene transcripts were found only in the transgenic lines with the wild-type promoter.

V beta 8. 3 gene transcripts


Input: One month after the DTaP booster vaccination, both groups had 6-to 40-fold increases in serum antibody concentrations to all antigens tested; the concentrations against the three pertussis antigens were higher in the DTaP-primed children (p < 0. 05).

pertussis antigens


Input: Interestingly, this amino-terminal determinant appears not to reside in the HSV-alpha TIF, which displays no independent amino-terminal activity.

alpha TIF


Input: We also show that in fusions with the DNA binding domain of GAL4, full activity requires the entire BHV-alpha TIF, although both amino and carboxyl termini display some activity on their own.

BHV-alpha TIF


Input: To investigate the potential role of SP1, we examined nuclear extracts from HCMV-infected cells.


Input: Here we show that messenger RNAs encoding trans-sialidases containing the repeats are not present in epimastigotes but are abundant in trypomastigotes.


Input: From May 1985 to May 1989, 126 necropsies were performed at the Sao Paulo City Morgue on cadavers of individuals AIDS victims whose unnatural deaths had prompted police investigations.


Input: A model with age and weight described the best fit for TBBMD, whereas age, weight, and height described the best fit for total body TBBMC.


Input: As retinoic acid and thyroid hormone are frequently involved in developmental regulatory processes, it is possible that this element may be important in the process of islet cell differentiation.


Input: The C-terminal peptide sequences of the human lymphocyte-specific high mobility group (HMG)-box transcription factor TCF-1 are determined by alternative splice mechanisms affecting the exons VIII to X.

human lymphocyte-specific high mobility group (HMG)-box transcription factor TCF-1


Input: Thromboxane B2 increased (97 +/-105 versus 40 +/-26 pg/ml) and was significantly higher during heparin free hemodialysis than during hemodialysis with heparin (p = 0. 01, Wilcoxon matched pairs signed rank test).


Input: To explore the mechanism of RSK activation, a cloned human RSK cDNA (RSK3) was used to generate and characterize several site-directed RSK mutants; K91A (N-Lys, NH2-terminal ATP-binding mutant), K444A (C-Lys, COOH-terminal ATP-binding mutant), N/C-Lys (double ATP-binding mutant) T570A (C-Thr, mutant of the putative MAPK phosphorylation site in subdomain VIII of the C-domain), S218A (N-Ser, mutant of the corresponding NH2-terminal residue).

RSK

RSK

RSK mutants

MAPK


Input: In contrast, both C-Lys and C-Thr retained high levels of kinase activity and were capable of responding to stimulation.


Input: Conversely, treatment of human protein-tyrosine phosphatase alpha-overexpressing cells with phenylarsine oxide led to a loss of the constitutive NF-kappa B activity.

human protein-tyrosine phosphatase alpha

NF-kappa B


Input: A TATA-less promoter containing binding sites for ubiquitous transcription factors mediates cell type-specific regulation of the gene for transcription enhancer factor-1 (TEF-1).

transcription enhancer factor-1


Input: Since electrical stimulation of neurones may activate not only cell bodies but also neuronal fibres, this study aimed to test a selectively cholinergic neurochemical stimulation of the rat substantia innominata (SI) by the local microinjection of carbachol; the effects of this acetylcholine agonist were compared with glutamate.


Input: We purified both proteins from human platelet membranes using DEAE-Sepharose chromatography followed by mAb F11 affinity chromatography.

mAb F11


Input: The homeobox gene ATK1 of Arabidopsis thaliana is expressed in the shoot apex of the seedling and in flowers and inflorescence stems of mature plants.

homeobox gene ATK1


Input: The most likely explanation for this is that gold principally accumulates in the Kupffer cells and renal cortex and these cells do not express Type I deiodinase.

Type I deiodinase


Input: These results suggest that different models of intestinal ischemia have different cytokine profiles and that the early TNF response associated with SMA occlusion model is primarily due to the laparotomy.

TNF


Input: Our evidence derives from three principal observations: 1) a transfection construct containing only 122 nucleotides (nt) of promoter 1 and 328 nt of the 5'-UTR retained full PGE2-stimulated reporter expression; 2) maximal PGE2-driven reporter expression required the presence of nt 196 to 328 of exon 1 when tested within the context of IGF-I promoter 1; 3) cotransfection of IGF-I promoter-luciferase-reporter constructs with a plasmid encoding the alpha-isoform of the catalytic subunit of murine cAMP-dependent protein kinase (PKA) produced results comparable to those seen with PGE2 treatment, whereas cotransfection with a plasmid encoding a mutant regulatory subunit of PKA that cannot bind cAMP blocked PGE2-induced reporter expression.

IGF-I promoter 1

IGF-I promoter

luciferase

murine cAMP-dependent protein kinase

PKA

PKA


Input: The changes after treatment were observed chiefly by electromyography while sensory and motor improvement were also recorded as auxiliary indicators.


Input: Band-shift assays and DNase I footprinting experiments using purified 42 kDa repressor isoform confirmed that CIRs 5 and 6 were indeed the targets for binding of this protein.

DNase I

CIRs 5 and 6


Input: Retransformation of uvsH77 mutants with the rescued cosmids from the MMS-resistant transformants resulted in restoration of both UV and MMS resistance to wild-type levels.

uvsH77 mutants


Input: Furthermore, this element confers p53 induction to the otherwise nonresponsive adenovirus major late promoter.


Input: In flies, the dShc protein physically associates with the activated Drosophila epidermal growth factor receptor homolog (DER) and is inducibly phosphorylated on tyrosine by DER.

dShc protein

Drosophila epidermal growth factor receptor homolog

DER

DER


Input: A potential binding site for the dShc PTB domain is located at Tyr-1228 of DER.

dShc

DER


Input: A Drosophila shc gene product is implicated in signaling by the DER receptor tyrosine kinase.

Drosophila shc gene product

DER receptor tyrosine kinase


Input: This inhibition can be overcome by mutating either the exon' s 5' or 3' splice site to make it correspond more closely to the relevant consensus sequence.


Input: Biochemical analysis shows that Ssm1p is a structural protein that forms part of the largest 60S ribosomal subunit, which does not exist in a pool of free proteins.

60S ribosomal subunit


Input: In wild-type cells, SSM1b transcripts accumulate to twice the level of SSM1a transcripts, suggesting that SSM1b is responsible for the majority of the Ssm1p pool.

SSM1b transcripts

SSM1a transcripts


Input: Northern blot analysis revealed the expression of LIMK-1 mRNA predominantly in the brain and the expression of LIMK-2 mRNA in various tissues in the rat.

LIMK-1 mRNA

LIMK-2 mRNA


Input: On the basis of this anatomic concept, the brachioplasty procedure was modified to provide secure anchoring of the arm flap to the axillary fascia along with strong superficial fascial system repair of incisions, reducing the risk of widening or migration of scars and unnatural contours.


Input: Furthermore, microinjection of dominant negative forms of Rac and Cdc42 or of the Rho inhibitor C3 transferase blocked serum-induced DNA synthesis.

Rac

Rho

C3 transferase


Input: INF-alpha therapy has been a major development in the treatment of CML.

INF-alpha


Input: A series of amino terminal deletion mutants (d10, d20, d27, d31, d40, d44, and d73) were compared for processing, cell surface expression, and maintenance of their biological attributes by recombinant expression of mutant genes using a plasmid vector (pcDL-SR alpha-296) in CV-1 and HeLa cells.


Input: Intrathecal acetyl cholinesterase inhibitors produce analgesia that is synergistic with morphine and clonidine in rats.

acetyl cholinesterase


Input: After determining isoflurane MAC in triplicate, birds were given a mu-opioid agonist (morphine, n = 9) or a kappa-opioid agonist (U50488H, n = 9).


Input: Max was constantly transcribed at a relatively low level during cell cycle progression.

Max


Input: The yeast enzyme was 6-fold slower than the mammalian enzymes, which made it amenable to pre-steady-state stopped-flow spectroscopic kinetic analysis at 30 degrees C and pH 6. 0.


Input: Key areas of the selection process including medical and surgical alternatives to transplantation, the composition of the transplant work-up, specific inclusion criteria as well as specific psychosocial factors and specific disease etiologies and co-morbidities that might represent contraindications were extensively reviewed.


Input: In both shoots and roots, GT-2 protein is undetectable in meristematic tissue but becomes expressed at later stages of cellular development, consistent with a role in contributing to the pattern of phytochrome A gene expression.

GT-2 protein

phytochrome A gene


Input: Comparative DNA sequence analysis showed the Genethon microsatellite D19S596 lies 2. 2 kb downstream of the coding region of FUT1, indicating that the cluster comprising the closely linked FUT1 and FUT2 genes is located 4 cM distal to D19S412 (lod score 13. 7) and 9 cM proximal to D19S571 (lod score 11. 7).

microsatellite D19S596

FUT2 genes